LOCUS 020_IIG_Bs22_SNP 3716900 bp DNA circular UNA 12-JAN-2021 DEFINITION Bacillus subtilis strain Delta6 (hybrid trycycler assembly). ACCESSION urn.local...1dn-cvskbta VERSION urn.local...1dn-cvskbta KEYWORDS . SOURCE ORGANISM . FEATURES Location/Qualifiers S_feature complement(3716790..658) /Source="Nicolas_S_feature" /locus_tag="new_299_1067_c" /HighExp="S4, LoTm, S3, C30, S5, S7, S6, T5.0H, S8, M9-stat" /AntisenseName="dnaA" /AntisenseCor="-0.57810076860528403" /AntisenseRegPval="-24.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S4" CDS 1..1341 /gene="dnaA" /locus_tag="BSU_00010" /old_locus_tag="BSU00010" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:2167836, 2846289, 12682299, 16120674, 1779750, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2167836, 2846289, 12682299, 16120674, 1779750, 28166228; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosomal replication initiator informational ATPase" /protein_id="NP_387882.1" /db_xref="EnsemblGenomes-Gn:BSU00010" /db_xref="EnsemblGenomes-Tr:CAB11777" /db_xref="GOA:P05648" /db_xref="InterPro:IPR001957" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR010921" /db_xref="InterPro:IPR013159" /db_xref="InterPro:IPR013317" /db_xref="InterPro:IPR018312" /db_xref="InterPro:IPR020591" /db_xref="InterPro:IPR024633" /db_xref="InterPro:IPR027417" /db_xref="PDB:4TPS" /db_xref="SubtiList:BG10065" /db_xref="UniProtKB/Swiss-Prot:P05648" /translation="MENILDLWNQALAQIEKKLSKPSFETWMKSTKAHSLQGDTLTIT APNEFARDWLESRYLHLIADTIYELTGEELSIKFVIPQNQDVEDFMPKPQVKKAVKED TSDFPQNMLNPKYTFDTFVIGSGNRFAHAASLAVAEAPAKAYNPLFIYGGVGLGKTHL MHAIGHYVIDHNPSAKVVYLSSEKFTNEFINSIRDNKAVDFRNRYRNVDVLLIDDIQF LAGKEQTQEEFFHTFNTLHEESKQIVISSDRPPKEIPTLEDRLRSRFEWGLITDITPP DLETRIAILRKKAKAEGLDIPNEVMLYIANQIDSNIRELEGALIRVVAYSSLINKDIN ADLAAEALKDIIPSSKPKVITIKEIQRVVGQQFNIKLEDFKAKKRTKSVAFPRQIAMY LSREMTDSSLPKIGEEFGGRDHTTVIHAHEKISKLLADDEQLQQHVKEIKEQLK*" /label="dnaA CDS" gene 1..1341 /gene="dnaA" /locus_tag="BSU_00010" /old_locus_tag="BSU00010" /label="dnaA gene" promotor_-10 complement(631..649) /Source="Nicolas_upshift_promotors" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(657) /Source="Nicolas_upshifts" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(665..670) /Source="Nicolas_upshift_promotors" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1342..1529 /Source="Nicolas_S_feature" /locus_tag="new_1751_1938" /HighExp="G150, Heat, G180, G135, Paraq, Oxctl, dia0, LBGstat, S1, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S5" CDS 1530..2666 /gene="dnaN" /locus_tag="BSU_00020" /old_locus_tag="BSU00020" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:2846289, 11395445, 12682299, 20453097, 23228104, 28878042" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2846289, 11395445, 12682299, 20453097, 23228104, 28878042; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (beta subunit)" /protein_id="NP_387883.1" /db_xref="EnsemblGenomes-Gn:BSU00020" /db_xref="EnsemblGenomes-Tr:CAB11778" /db_xref="GOA:P05649" /db_xref="InterPro:IPR001001" /db_xref="InterPro:IPR022634" /db_xref="InterPro:IPR022635" /db_xref="InterPro:IPR022637" /db_xref="PDB:4TR6" /db_xref="SubtiList:BG10066" /db_xref="UniProtKB/Swiss-Prot:P05649" /translation="MKFTIQKDRLVESVQDVLKAVSSRTTIPILTGIKIVASDDGVSF TGSDSDISIESFIPKEEGDKEIVTIEQPGSIVLQARFFSEIVKKLPMATVEIEVQNQY LTIIRSGKAEFNLNGLDADEYPHLPQIEEHHAIQIPTDLLKNLIRQTVFAVSTSETRP ILTGVNWKVEQSELLCTATDSHRLALRKAKLDIPEDRSYNVVIPGKSLTELSKILDDN QELVDIVITETQVLFKAKNVLFFSRLLDGNYPDTTSLIPQDSKTEIIVNTKEFLQAID RASLLAREGRNNVVKLSAKPAESIEISSNSPEIGKVVEAIVADQIEGEELNISFSPKY MLDALKVLEGAEIRVSFTGAMRPFLIRTPNDETIVQLILPVRTY*" /label="dnaN CDS" gene 1530..2666 /gene="dnaN" /locus_tag="BSU_00020" /old_locus_tag="BSU00020" /label="dnaN gene" downshifts 2650 /Source="Nicolas_upshifts" /id="D1" /incds=0 /nref=29 /ntot=161 /MaxReadThrough="5.22584" /MaxDrop="4.17087" /score="21.887269" /energy="-14.2" /TU="U1" /idTUdmin="U1" /TUdmin="-572" /isTUend="FALSE" /label="downshifts" promotor_-35 2731..2735 /Source="Nicolas_upshift_promotors" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2752..2771 /Source="Nicolas_upshift_promotors" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2760 /Source="Nicolas_upshifts" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="upshifts" CDS 2797..3012 /gene="rlbA" /locus_tag="BSU_00030" /old_locus_tag="BSU00030" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:24637032, 24939895" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24637032, 24939895; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA binding protein involved in ribosome maturation" /protein_id="NP_387884.1" /db_xref="EnsemblGenomes-Gn:BSU00030" /db_xref="EnsemblGenomes-Tr:CAB11779" /db_xref="GOA:P05650" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014330" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10067" /db_xref="UniProtKB/Swiss-Prot:P05650" /translation="MANPISIDTEMITLGQFLKLADVIQSGGMAKWFLSEHEVLVNDE PDNRRGRKLYVGDVVEIEGFGSFQVVN*" /label="rlbA CDS" gene 2797..3012 /gene="rlbA" /locus_tag="BSU_00030" /old_locus_tag="BSU00030" /label="rlbA gene" CDS 3028..4140 /gene="recF" /locus_tag="BSU_00040" /old_locus_tag="BSU00040" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:15186413, 16061691, 16385024, 22342069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15186413, 16061691, 16385024, 22342069; Product type f: factor" /codon_start=1 /transl_table=11 /product="RecA filament-DNA complex stabilisation, ssDNA and dsDNA binding, ATP binding" /protein_id="NP_387885.1" /db_xref="EnsemblGenomes-Gn:BSU00040" /db_xref="EnsemblGenomes-Tr:CAB11780" /db_xref="GOA:P05651" /db_xref="InterPro:IPR001238" /db_xref="InterPro:IPR003395" /db_xref="InterPro:IPR018078" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10068" /db_xref="UniProtKB/Swiss-Prot:P05651" /translation="MYIQNLELTSYRNYDHAELQFENKVNVIIGENAQGKTNLMEAIY VLSMAKSHRTSNDKELIRWDKDYAKIEGRVMKQNGAIPMQLVISKKGKKGKVNHIEQQ KLSQYVGALNTIMFAPEDLNLVKGSPQVRRRFLDMEIGQVSPVYLHDLSLYQKILSQR NHFLKQLQTRKQTDRTMLDVLTDQLVEVAAKVVVKRLQFTAQLEKWAQPIHAGISRGL EELTLKYHTALDVSDPLDLSKIGDSYQEAFSKLREKEIERGVTLSGPHRDDVLFYVNG RDVQTYGSQGQQRTTALSLKLAEIDLIHEEIGEYPILLLDDVLSELDDYRQSHLLHTI QGRVQTFVTTTSVDGIDHETLRQAGMFRVQNGALVK*" /label="recF CDS" gene 3028..4140 /gene="recF" /locus_tag="BSU_00040" /old_locus_tag="BSU00040" /label="recF gene" misc_feature 3226..3245 /Source="Nicolas_upshift_promotors" /id="U5" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2750 /SigmaFactorBS="cggacatcaaatgacaaagaacttatacggtgggacaaagac TATGCTAAAATAGAGGGAAGagtgatgaagcaaaacggggcgatcccgatgcagctcg t" /listShort="yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3244 /Source="Nicolas_upshifts" /id="U5" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2750 /SigmaFactorBS="cggacatcaaatgacaaagaacttatacggtgggacaaagac TATGCTAAAATAGAGGGAAGagtgatgaagcaaaacggggcgatcccgatgcagctcg t" /listShort="yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="upshifts" CDS 4158..4403 /gene="remB" /locus_tag="BSU_00050" /old_locus_tag="BSU00050" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19363116" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19363116; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of extracellular matrix formation" /protein_id="NP_387886.2" /db_xref="EnsemblGenomes-Gn:BSU00050" /db_xref="EnsemblGenomes-Tr:CAB11781" /db_xref="InterPro:IPR007169" /db_xref="SubtiList:BG10069" /db_xref="UniProtKB/Swiss-Prot:P37525" /translation="MYIHLGDDFVVSTRDIVGIFDFKANMSPIVEEFLKKQKHKVVPS VNGTPKSIVVTVQNIYYSPLSSSTLKKRAQFMFEIDS*" /label="remB CDS" gene 4158..4403 /gene="remB" /locus_tag="BSU_00050" /old_locus_tag="BSU00050" /label="remB gene" CDS 4458..6374 /gene="gyrB" /locus_tag="BSU_00060" /old_locus_tag="BSU00060" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12682299, 12767818, 17320901" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12767818, 17320901; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA gyrase (subunit B)" /protein_id="NP_387887.1" /db_xref="EnsemblGenomes-Gn:BSU00060" /db_xref="EnsemblGenomes-Tr:CAB11782" /db_xref="GOA:P05652" /db_xref="InterPro:IPR001241" /db_xref="InterPro:IPR002288" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR011557" /db_xref="InterPro:IPR013506" /db_xref="InterPro:IPR013759" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018522" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR034160" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10070" /db_xref="UniProtKB/Swiss-Prot:P05652" /translation="MEQQQNSYDENQIQVLEGLEAVRKRPGMYIGSTNSKGLHHLVWE IVDNSIDEALAGYCTDINIQIEKDNSITVVDNGRGIPVGIHEKMGRPAVEVIMTVLHA GGKFDGSGYKVSGGLHGVGASVVNALSTELDVTVHRDGKIHRQTYKRGVPVTDLEIIG ETDHTGTTTHFVPDPEIFSETTEYDYDLLANRVRELAFLTKGVNITIEDKREGQERKN EYHYEGGIKSYVEYLNRSKEVVHEEPIYIEGEKDGITVEVALQYNDSYTSNIYSFTNN INTYEGGTHEAGFKTGLTRVINDYARKKGLIKENDPNLSGDDVREGLTAIISIKHPDP QFEGQTKTKLGNSEARTITDTLFSTAMETFMLENPDAAKKIVDKGLMAARARMAAKKA RELTRRKSALEISNLPGKLADCSSKDPSISELYIVEGDSAGGSAKQGRDRHFQAILPL RGKILNVEKARLDKILSNNEVRSMITALGTGIGEDFNLEKARYHKVVIMTDADVDGAH IRTLLLTFFYRYMRQIIENGYVYIAQPPLYKVQQGKRVEYAYNDKELEELLKTLPQTP KPGLQRYKGLGEMNATQLWETTMDPSSRTLLQVTLEDAMDADETFEMLMGDKVEPRRN FIEANARYVKNLDI*" /label="gyrB CDS" gene 4458..6374 /gene="gyrB" /locus_tag="BSU_00060" /old_locus_tag="BSU00060" /label="gyrB gene" promotor_-10 complement(6003..6021) /Source="Nicolas_upshift_promotors" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(6005) /Source="Nicolas_upshifts" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(6037..6042) /Source="Nicolas_upshift_promotors" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 6375..6584 /Source="Nicolas_S_feature" /locus_tag="new_6784_6993" /HighExp="Cold, H2O2, G180, Oxctl, G135, G150, Sw, dia15, LBGexp, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S6" CDS 6585..9050 /gene="gyrA" /locus_tag="BSU_00070" /old_locus_tag="BSU00070" /EC_number="5.99.1.3" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 12767818, 17320901, 27557712" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12767818, 17320901, 27557712; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA gyrase (subunit A)" /protein_id="NP_387888.1" /db_xref="EnsemblGenomes-Gn:BSU00070" /db_xref="EnsemblGenomes-Tr:CAB11783" /db_xref="GOA:P05653" /db_xref="InterPro:IPR002205" /db_xref="InterPro:IPR005743" /db_xref="InterPro:IPR006691" /db_xref="InterPro:IPR013757" /db_xref="InterPro:IPR013758" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR035516" /db_xref="PDB:4DDQ" /db_xref="SubtiList:BG10071" /db_xref="UniProtKB/Swiss-Prot:P05653" /translation="MSEQNTPQVREINISQEMRTSFLDYAMSVIVSRALPDVRDGLKP VHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYM LVDGHGNFGSVDGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVM PSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIPELMEVIPGPDF PTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPYQVNKAKLIEK IADLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGINL LALVDGQPKVLTLKQCLEHYLDHQKVVIRRRTAYELRKAEARAHILEGLRVALDHLDA VISLIRNSQTAEIARTGLIEQFSLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLVKL IAELKDILANEYKVLEIIREELTEIKERFNDERRTEIVTSGLETIEDEDLIERENIVV TLTHNGYVKRLPASTYRSQKRGGKGVQGMGTNEDDFVEHLISTSTHDTILFFSNKGKV YRAKGYEIPEYGRTAKGIPIINLLEVEKGEWINAIIPVTEFNAELYLFFTTKHGVSKR TSLSQFANIRNNGLIALSLREDDELMGVRLTDGTKQIIIGTKNGLLIRFPETDVREMG RTAAGVKGITLTDDDVVVGMEILEEESHVLIVTEKGYGKRTPAEEYRTQSRGGKGLKT AKITENNGQLVAVKATKGEEDLMIITASGVLIRMDINDISITGRVTQGVRLIRMAEEE HVATVALVEKNEEDENEEEQEEV*" /label="gyrA CDS" gene 6585..9050 /gene="gyrA" /locus_tag="BSU_00070" /old_locus_tag="BSU00070" /label="gyrA gene" promotor_-35 8964..8967 /Source="Nicolas_upshift_promotors" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 8965 /Source="Nicolas_upshifts" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 8984..9001 /Source="Nicolas_upshift_promotors" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 9031 /Source="Nicolas_upshifts" /id="D2" /incds=0 /nref=251 /ntot=261 /MaxReadThrough="3.73971" /MaxDrop="8.1288" /score="33.5021066" /energy="-14.1" /TU="NA" /idTUdmin="U4" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 9095..9101 /Source="Nicolas_upshift_promotors" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 9115..9134 /Source="Nicolas_upshift_promotors" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 9120..9205 /Source="Nicolas_S_feature" /locus_tag="new_9529_9614" /HighExp="LBGstat, H2O2, Paraq, Oxctl, UNK1, LBGexp, LPhT, MG-0.2, MG 25, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S7" upshifts 9120 /Source="Nicolas_upshifts" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 9191..9198 /Source="Nicolas_upshift_promotors" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 9207 /Source="Nicolas_upshifts" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 9213..9232 /Source="Nicolas_upshift_promotors" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" rRNA 9401..10955 /gene="rrnO-16S" /locus_tag="BSU_rRNA_1" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnO-16S rRNA" gene 9401..10955 /gene="rrnO-16S" /locus_tag="BSU_rRNA_1" /label="rrnO-16S gene" tRNA 11055..11131 /gene="trnO-Ile" /locus_tag="BSU_tRNA_5" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnO-Ile tRNA" gene 11055..11131 /gene="trnO-Ile" /locus_tag="BSU_tRNA_5" /label="trnO-Ile gene" tRNA 11143..11218 /gene="trnO-Ala" /locus_tag="BSU_tRNA_6" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnO-Ala tRNA" gene 11143..11218 /gene="trnO-Ala" /locus_tag="BSU_tRNA_6" /label="trnO-Ala gene" rRNA 11300..14227 /gene="rrnO-23S" /locus_tag="BSU_rRNA_2" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnO-23S rRNA" gene 11300..14227 /gene="rrnO-23S" /locus_tag="BSU_rRNA_2" /label="rrnO-23S gene" rRNA 14283..14401 /gene="rrnO-5S" /locus_tag="BSU_rRNA_3" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnO-5S rRNA" gene 14283..14401 /gene="rrnO-5S" /locus_tag="BSU_rRNA_3" /label="rrnO-5S gene" S_feature 14402..15459 /Source="Nicolas_S_feature" /locus_tag="new_14811_15868" /HighExp="G180, T0.0H, T0.30H, G135, T-0.40H, LBGstat, Cold, Paraq, C30, Oxctl" /AntisenseName="yaaC" /AntisenseCor="-4.5985764709218099E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S8" CDS complement(14438..15385) /gene="yaaC" /locus_tag="BSU_00080" /old_locus_tag="BSU00080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387889.1" /db_xref="EnsemblGenomes-Gn:BSU00080" /db_xref="EnsemblGenomes-Tr:CAB11784" /db_xref="InterPro:IPR026988" /db_xref="SubtiList:BG10072" /db_xref="UniProtKB/Swiss-Prot:P37526" /translation="MTYHEWKDLALFYSVESTQKFLEKVYILNGINDAKKNSFKNSER FIYFLKHAESFYKQAAYSPLEIKPILLFYGMAQLIKACLITRDPHYPSHTSVLAHGVT TRKRKKQNYCFSDDEVKIQRNGLCVHFMKHLFGQSDIVDERYTMKKLLMAIPELSDIF YFQQKERFMTKVEKDKNEIFVPEEVVINYKMSDSRFAEYMSHHYQWSFTKKNEHGLLF EISPQDKEPWTSTSLLFDMEKNQYYIPSQREQFLRLPEMTIHYLILYNVGMIARYETE WWYELLTQHISDDYVLIQQFLLVSEKKFPKYASQFLLHF*" /label="yaaC CDS" gene complement(14438..15385) /gene="yaaC" /locus_tag="BSU_00080" /old_locus_tag="BSU00080" /label="yaaC gene" promotor_-35 15438..15445 /Source="Nicolas_upshift_promotors" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 15460..15479 /Source="Nicolas_upshift_promotors" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 15461 /Source="Nicolas_upshifts" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(15466) /Source="Nicolas_upshifts" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(15475..15486) /Source="Nicolas_upshift_promotors" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(15500..15506) /Source="Nicolas_upshift_promotors" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 15506..16972 /gene="guaB" /locus_tag="BSU_00090" /old_locus_tag="BSU00090" /EC_number="1.1.1.205" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1722815, 17611193, 1979163, 3125411, 8917437" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1722815, 17611193, 1979163, 3125411, 8917437; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="inosine-monophosphate dehydrogenase" /protein_id="NP_387890.1" /db_xref="EnsemblGenomes-Gn:BSU00090" /db_xref="EnsemblGenomes-Tr:CAB11785" /db_xref="GOA:P21879" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR001093" /db_xref="InterPro:IPR005990" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR015875" /db_xref="SubtiList:BG10073" /db_xref="UniProtKB/Swiss-Prot:P21879" /translation="MWESKFSKEGLTFDDVLLVPAKSEVLPRDVDLSVELTKTLKLNI PVISAGMDTVTESAMAIAMARQGGLGIIHKNMSIEQQAEQVDKVKRSERGVITNPFFL TPDHQVFDAEHLMGKYRISGVPIVNNEEDQKLVGIITNRDLRFISDYSMKISDVMTKE ELVTASVGTTLDEAEKILQKHKIEKLPLVDDQNKLKGLITIKDIEKVIEFPNSSKDIH GRLIVGAAVGVTGDTMTRVKKLVEANVDVIVIDTAHGHSQGVLNTVTKIRETYPELNI IAGNVATAEATRALIEAGADVVKVGIGPGSICTTRVVAGVGVPQITAIYDCATEARKH GKTIIADGGIKFSGDITKALAAGGHAVMLGSLLAGTSESPGETEIYQGRRFKVYRGMG SVAAMEKGSKDRYFQEENKKFVPEGIEGRTPYKGPVEETVYQLVGGLRSGMGYCGSKD LRALREEAQFIRMTGAGLRESHPHDVQITKESPNYTIS*" /label="guaB CDS" gene 15506..16972 /gene="guaB" /locus_tag="BSU_00090" /old_locus_tag="BSU00090" /label="guaB gene" downshifts complement(15510) /Source="Nicolas_upshifts" /id="D3" /incds=0 /nref=33 /ntot=102 /MaxReadThrough="1.81989" /MaxDrop="4.44626" /score="-6.76739893" /energy="-12.2" /TU="NA" /idTUdmin="U12" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(15536..15636) /Source="Nicolas_upshift_promotors" /id="U12" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.922077922077922" /psig="0.016983016983017" /xcortree=82 /SigmaFactorBS="atatttagctttaacgtttttgtaagttctacagataaatcc acatcacgcggaagtacctcagactttgctggtacaagcagcacatcgtcgaacgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(15576) /Source="Nicolas_upshifts" /id="U12" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.922077922077922" /psig="0.016983016983017" /xcortree=82 /SigmaFactorBS="atatttagctttaacgtttttgtaagttctacagataaatcc acatcacgcggaagtacctcagactttgctggtacaagcagcacatcgtcgaacgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(16829..17424) /Source="Nicolas_S_feature" /locus_tag="new_17238_17833_c" /HighExp="Etha, Gly, C30, Salt, S8, S6, HiTm, S7, Sw, C90" /AntisenseName="dacA" /AntisenseCor="-0.39306815699287101" /AntisenseRegPval="-10.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S9" downshifts 16960 /Source="Nicolas_upshifts" /id="D4" /incds=0 /nref=243 /ntot=277 /MaxReadThrough="3.34899" /MaxDrop="7.78161" /score="26.7620012" /energy="-10.6" /TU="NA" /idTUdmin="U10" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" promotor_-35 17018..17022 /Source="Nicolas_upshift_promotors" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 17038..17057 /Source="Nicolas_upshift_promotors" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 17044..17124 /Source="Nicolas_S_feature" /locus_tag="new_17453_17533" /HighExp="C30, LBGstat, G180, G150, LBGexp, G135, Lbexp, Oxctl, dia0, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S10" upshifts 17044 /Source="Nicolas_upshifts" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="upshifts" CDS 17125..18456 /gene="dacA" /locus_tag="BSU_00100" /old_locus_tag="BSU00100" /EC_number="3.4.16.4" /experiment="publication(s) with functional evidences, PMID:8370539, 9864321, 10383963, 21378199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8370539, 9864321, 10383963, 21378199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5)" /protein_id="NP_387891.1" /db_xref="EnsemblGenomes-Gn:BSU00100" /db_xref="EnsemblGenomes-Tr:CAB11786" /db_xref="GOA:P08750" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR015956" /db_xref="InterPro:IPR018044" /db_xref="InterPro:IPR037167" /db_xref="SubtiList:BG10074" /db_xref="UniProtKB/Swiss-Prot:P08750" /translation="MNIKKCKQLLMSLVVLTLAVTCLAPMSKAKAASDPIDINASAAI MIEASSGKILYSKNADKRLPIASMTKMMTEYLLLEAIDQGKVKWDQTYTPDDYVYEIS QDNSLSNVPLRKDGKYTVKELYQATAIYSANAAAIAIAEIVAGSETKFVEKMNAKAKE LGLTDYKFVNATGLENKDLHGHQPEGTSVNEESEVSAKDMAVLADHLITDYPEILETS SIAKTKFREGTDDEMDMPNWNFMLKGLVSEYKKATVDGLKTGSTDSAGSCFTGTAERN GMRVITVVLNAKGNLHTGRFDETKKMFDYAFDNFSMKEIYAEGDQVKGHKTISVDKGK EKEVGIVTNKAFSLPVKNGEEKNYKAKVTLNKDNLTAPVKKGTKVGKLTAEYTGDEKD YGFLNSDLAGVDLVTKENVEKANWFVLTMRSIGGFFAGIWGSIVDTVTGWF*" /label="dacA CDS" gene 17125..18456 /gene="dacA" /locus_tag="BSU_00100" /old_locus_tag="BSU00100" /label="dacA gene" promotor_-10 complement(17413..17431) /Source="Nicolas_upshift_promotors" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(17424) /Source="Nicolas_upshifts" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(17446..17452) /Source="Nicolas_upshift_promotors" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 18338 /Source="Nicolas_upshifts" /id="D5" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="6.76335" /MaxDrop="2.1925" /score="26.7620012" /energy="-10.6" /TU="U13" /idTUdmin="U10" /TUdmin=1364 /isTUend="FALSE" /label="downshifts" S_feature 18457..18565 /Source="Nicolas_S_feature" /locus_tag="new_18866_18974" /HighExp="C30, MG 15, MG 10, MG-0.1, MG 25, BMM, ferm, Cold, MG 60, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S11" promotor_-35 18535..18538 /Source="Nicolas_upshift_promotors" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 18553..18572 /Source="Nicolas_upshift_promotors" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 18567..18652 /Source="Nicolas_S_feature" /locus_tag="new_18976_19061" /HighExp="BMM, MG 25, SMM, MG 15, UNK1, MG 10, GM 150, MG-0.1, MG 150, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S12" upshifts 18567 /Source="Nicolas_upshifts" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="upshifts" CDS 18653..19537 /gene="pdxS" /locus_tag="BSU_00110" /old_locus_tag="BSU00110" /EC_number="4.3.3.6" /EC_number="4.-.-.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14762015, 15771487, 15911615, 16157873, 17144654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762015, 15771487, 15911615, 16157873, 17144654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine amidotransferase for pyridoxal phosphate synthesis; pyridoxal 5'-phosphate synthase complex, synthase subunit" /protein_id="NP_387892.1" /db_xref="EnsemblGenomes-Gn:BSU00110" /db_xref="EnsemblGenomes-Tr:CAB11787" /db_xref="GOA:P37527" /db_xref="InterPro:IPR001852" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR033755" /db_xref="PDB:2NV1" /db_xref="PDB:2NV2" /db_xref="SubtiList:BG10075" /db_xref="UniProtKB/Swiss-Prot:P37527" /translation="MAQTGTERVKRGMAEMQKGGVIMDVINAEQAKIAEEAGAVAVMA LERVPADIRAAGGVARMADPTIVEEVMNAVSIPVMAKARIGHIVEARVLEAMGVDYID ESEVLTPADEEFHLNKNEYTVPFVCGCRDLGEATRRIAEGASMLRTKGEPGTGNIVEA VRHMRKVNAQVRKVVAMSEDELMTEAKNLGAPYELLLQIKKDGKLPVVNFAAGGVATP ADAALMMQLGADGVFVGSGIFKSDNPAKFAKAIVEATTHFTDYKLIAELSKELGTAMK GIEISNLLPEQRMQERGW*" /label="pdxS CDS" gene 18653..19537 /gene="pdxS" /locus_tag="BSU_00110" /old_locus_tag="BSU00110" /label="pdxS gene" S_feature complement(18785..19514) /Source="Nicolas_S_feature" /locus_tag="new_19194_19923_c" /HighExp="S6, S8, S7, S5, S4, C30, S3, BT, C90, Gly" /AntisenseName="pdxS" /AntisenseCor="-0.65390240445415004" /AntisenseRegPval="-33.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S13" promotor_-10 complement(19502..19520) /Source="Nicolas_upshift_promotors" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(19514) /Source="Nicolas_upshifts" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(19536..19541) /Source="Nicolas_upshift_promotors" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="promotor_-35" CDS 19559..20149 /gene="pdxT" /locus_tag="BSU_00120" /old_locus_tag="BSU00120" /EC_number="3.5.1.2" /EC_number="4.3.3.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14585832, 14762015, 15771487, 17144654, 18271580, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14585832, 14762015, 15771487, 17144654, 18271580, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glutamine amidotransferase for pyridoxal phosphate synthesis; pyridoxal 5'-phosphate synthase complex, glutamine amidotransferase subunit PdxT" /protein_id="NP_387893.1" /db_xref="EnsemblGenomes-Gn:BSU00120" /db_xref="EnsemblGenomes-Tr:CAB11788" /db_xref="GOA:P37528" /db_xref="InterPro:IPR002161" /db_xref="InterPro:IPR021196" /db_xref="InterPro:IPR029062" /db_xref="PDB:1R9G" /db_xref="PDB:2NV0" /db_xref="PDB:2NV2" /db_xref="SubtiList:BG10076" /db_xref="UniProtKB/Swiss-Prot:P37528" /translation="MLTIGVLGLQGAVREHIHAIEACGAAGLVVKRPEQLNEVDGLIL PGGESTTMRRLIDTYQFMEPLREFAAQGKPMFGTCAGLIILAKEIAGSDNPHLGLLNV VVERNSFGRQVDSFEADLTIKGLDEPFTGVFIRAPHILEAGENVEVLSEHNGRIVAAK QGQFLGCSFHPELTEDHRVTQLFVEMVEEYKQKALV*" /label="pdxT CDS" gene 19559..20149 /gene="pdxT" /locus_tag="BSU_00120" /old_locus_tag="BSU00120" /label="pdxT gene" misc_RNA 20202..20414 /gene="tboS" /locus_tag="BSU_misc_RNA_1" /product="T-box riboswitch specific of serine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboS RNA" gene 20202..20414 /gene="tboS" /locus_tag="BSU_misc_RNA_1" /label="tboS gene" downshifts 20379 /Source="Nicolas_upshifts" /id="D6" /incds=0 /nref=9 /ntot=80 /MaxReadThrough="7.14793" /MaxDrop="4.37654" /score="41.1243331" /energy="-23.3" /TU="U13,U15" /idTUdmin="U13" /TUdmin="-1347" /isTUend="FALSE" /label="downshifts" CDS 20471..21748 /gene="serS" /locus_tag="BSU_00130" /old_locus_tag="BSU00130" /EC_number="6.1.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10546897, 12682299, 14732487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10546897, 12682299, 14732487; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="seryl-tRNA synthetase" /protein_id="NP_387894.1" /db_xref="EnsemblGenomes-Gn:BSU00130" /db_xref="EnsemblGenomes-Tr:CAB11789" /db_xref="GOA:P37464" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002317" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR015866" /db_xref="InterPro:IPR033729" /db_xref="SubtiList:BG10077" /db_xref="UniProtKB/Swiss-Prot:P37464" /translation="MLDTKMLRANFQEIKAKLVHKGEDLTDFDKFEALDDRRRELIGK VEELKGKRNEVSQQVAVLKREKKDADHIIKEMREVGEEIKKLDEELRTVEAELDTILL SIPNIPHESVPVGETEDDNVEVRKWGEKPSFAYEPKPHWDIADELGILDFERAAKVTG SRFVFYKGLGARLERALYNFMLDLHVDEYNYTEVIPPYMVNRASMTGTGQLPKFEEDA FKIREEDYFLIPTAEVPITNMHRDEILSGDSLPINYAAFSACFRSEAGSAGRDTRGLI RQHQFNKVELVKFVKPEDSYEELEKLTNQAERVLQLLELPYRVMSMCTGDLGFTAAKK YDIEVWIPSQDTYREISSCSNFEAFQARRANIRFRREAKGKPEHVHTLNGSGLAVGRT VAAILENYQQEDGSVVIPKVLRPYMGNREVMKP*" /label="serS CDS" gene 20471..21748 /gene="serS" /locus_tag="BSU_00130" /old_locus_tag="BSU00130" /label="serS gene" downshifts 21726 /Source="Nicolas_upshifts" /id="D7" /incds=0 /nref=234 /ntot=255 /MaxReadThrough="0.83411" /MaxDrop="7.38039" /score="17.6549558" /energy="-13.3" /TU="NA" /idTUdmin="U13" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 21837..21844 /Source="Nicolas_upshift_promotors" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 21859..21878 /Source="Nicolas_upshift_promotors" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 21859 /Source="Nicolas_upshifts" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="upshifts" tRNA 21883..21975 /gene="trnSL-Ser1" /locus_tag="BSU_tRNA_7" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(UGA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Ser1 tRNA" gene 21883..21975 /gene="trnSL-Ser1" /locus_tag="BSU_tRNA_7" /label="trnSL-Ser1 gene" downshifts 21998 /Source="Nicolas_upshifts" /id="D8" /incds=0 /nref=168 /ntot=196 /MaxReadThrough="5.02201" /MaxDrop="8.36635" /score="29.7083093" /energy="-12.4" /TU="U17" /idTUdmin="U13" /TUdmin=272 /isTUend="FALSE" /label="downshifts" S_feature 22043..22120 /Source="Nicolas_S_feature" /locus_tag="new_22452_22529" /HighExp="Cold, H2O2, G180, Paraq, Oxctl, C30, G150, G135, BMM, Heat" /AntisenseName="dck" /AntisenseCor="0.61769771609764101" /AntisenseRegPval="-29" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S14" CDS complement(22087..22740) /gene="dck" /locus_tag="BSU_00140" /old_locus_tag="BSU00140" /EC_number="2.7.1.76" /EC_number="2.7.1.74" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6251049, 11078735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6251049, 11078735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyadenosine/deoxycytidine kinase" /protein_id="NP_387895.1" /db_xref="EnsemblGenomes-Gn:BSU00140" /db_xref="EnsemblGenomes-Tr:CAB11790" /db_xref="GOA:P37529" /db_xref="InterPro:IPR002624" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031314" /db_xref="SubtiList:BG10078" /db_xref="UniProtKB/Swiss-Prot:P37529" /translation="MKEHHIPKNSIITVAGTVGVGKSTLTKTLAKRLGFKTSLEEVDH NPYLEKFYHDFERWSFHLQIYFLAERFKEQKTIFEAGGGFVQDRSIYEDTGIFAKMHA DKGTMSKVDYKTYTSLFEAMVMTPYFPHPDVLIYLEGDLENILNRIEQRGREMELQTS RSYWEEMHTRYENWISGFNACPVLKLRIEDYDLLNDENSIENIVDQIASVIHDNQKK* " /label="dck CDS" gene complement(22087..22740) /gene="dck" /locus_tag="BSU_00140" /old_locus_tag="BSU00140" /label="dck gene" promotor_-35 22106..22112 /Source="Nicolas_upshift_promotors" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(22111) /Source="Nicolas_upshifts" /id="D9" /incds=0 /nref=88 /ntot=213 /MaxReadThrough="1.96668" /MaxDrop="4.49235" /score="14.5948578" /energy="-11" /TU="NA" /idTUdmin="U19" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature 22122..22758 /Source="Nicolas_S_feature" /locus_tag="new_22531_23167" /HighExp="G180, G135, Cold, C30, Paraq, H2O2, Oxctl, G150, S5, S6" /AntisenseName="dck" /AntisenseCor="0.15155468296621499" /AntisenseRegPval="-1.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S15" upshifts 22122 /Source="Nicolas_upshifts" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 22126..22137 /Source="Nicolas_upshift_promotors" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(22737..23360) /gene="dgk" /locus_tag="BSU_00150" /old_locus_tag="BSU00150" /EC_number="2.7.1.113" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11078735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11078735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyguanosine kinase" /protein_id="NP_387896.1" /db_xref="EnsemblGenomes-Gn:BSU00150" /db_xref="EnsemblGenomes-Tr:CAB11791" /db_xref="GOA:P37530" /db_xref="InterPro:IPR002624" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031314" /db_xref="SubtiList:BG10079" /db_xref="UniProtKB/Swiss-Prot:P37530" /translation="MNTAPFIAIEGPIGAGKTTLATMLSQKFGFPMINEIVEDNPYLD KFYDNIKEWSFQLEMFFLCHRYKQLEDTSDHFLKKGQPVIADYHIYKNVIFAERTLSP HQLEKYKKIYHLLTDDLPKPNFIIYIKASLPTLLHRIEKRGRPFEKKIETSYLEQLIS DYEVAIKQLQEADPELTVLTVDGDSKDFVLNKSDFERIAAHVKELIV*" /label="dgk CDS" gene complement(22737..23360) /gene="dgk" /locus_tag="BSU_00150" /old_locus_tag="BSU00150" /label="dgk gene" promotor_-10 complement(23401..23420) /Source="Nicolas_upshift_promotors" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(23419) /Source="Nicolas_upshifts" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(23436..23440) /Source="Nicolas_upshift_promotors" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(23459..24742) /gene="sleL" /locus_tag="BSU_00160" /old_locus_tag="BSU00160" /EC_number="3.2.1.-" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11011148, 11737650, 12177332, 10419957, 18456807, 18835992, 19933362, 28333204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore peptidoglycan N-acetylglucosaminidase" /protein_id="NP_387897.1" /db_xref="EnsemblGenomes-Gn:BSU00160" /db_xref="EnsemblGenomes-Tr:CAB11792" /db_xref="GOA:P37531" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG10080" /db_xref="UniProtKB/Swiss-Prot:P37531" /translation="MVKQGDTLSAIASQYRTTTNDITETNEIPNPDSLVVGQTIVIPI AGQFYDVKRGDTLTSIARQFNTTAAELARVNRIQLNTVLQIGFRLYIPPAPKRDIESN AYLEPRGNQVSENLQQAAREASPYLTYLGAFSFQAQRNGTLVAPPLTNLRSITESQNT TLMMIITNLENQAFSDELGRILLNDETVKRRLLNEIVENARRYGFRDIHFDFEYLRPQ DREAYNQFLREARDLFHREGLEISTALAPKTSATQQGRWYEAHDYRAHGEIVDFVVLM TYEWGYSGGPPQAVSPIGPVRDVIEYALTEMPANKIVMGQNLYGYDWTLPYTAGGTPA RAVSPQQAIVIADQNNASIQYDQTAQAPFFRYTDAENRRHEVWFEDARSIQAKFNLIK ELNLRGISYWKLGLSFPQNWLLLSDQFNVVKKTFR*" /label="sleL CDS" gene complement(23459..24742) /gene="sleL" /locus_tag="BSU_00160" /old_locus_tag="BSU00160" /label="sleL gene" downshifts complement(23496) /Source="Nicolas_upshifts" /id="D10" /incds=0 /nref=40 /ntot=61 /MaxReadThrough="1.17442" /MaxDrop="6.30997" /score="3.66560192" /energy="-8.4" /TU="NA" /idTUdmin="U20" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(24773..24791) /Source="Nicolas_upshift_promotors" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(24794) /Source="Nicolas_upshifts" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(24807..24812) /Source="Nicolas_upshift_promotors" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(24812..25357) /gene="yaaI" /locus_tag="BSU_00170" /old_locus_tag="BSU00170" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2521622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidase (isochorismatase family)" /protein_id="NP_387898.1" /db_xref="EnsemblGenomes-Gn:BSU00170" /db_xref="EnsemblGenomes-Tr:CAB11793" /db_xref="GOA:P37532" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG10081" /db_xref="UniProtKB/Swiss-Prot:P37532" /translation="MSKADKALLIVDMINNFEFDMGETLAKKTEKIVPHILSLKEHAR QNEWPIIYINDHYGLWQADIKNIQQECTNERSKDIITKIAPVDADYFLIKPKHSAFYE TALHTLLTELQVRHIIITGIAGNICVLFTANDAYMREYSITIPKDCIASNSDEDNEFA LTMMENVLFAEITTEEQIIEK*" /label="yaaI CDS" gene complement(24812..25357) /gene="yaaI" /locus_tag="BSU_00170" /old_locus_tag="BSU00170" /label="yaaI gene" promotor_-35 25223..25227 /Source="Nicolas_upshift_promotors" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-35" promotor_-10 25242..25261 /Source="Nicolas_upshift_promotors" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-10" S_feature 25246..25442 /Source="Nicolas_S_feature" /locus_tag="new_25655_25851" /HighExp="Diami, dia5, H2O2, dia15, T0.30H, T-0.40H, HiOs, T-1.10H, Salt, T0.0H" /AntisenseName="yaaI" /AntisenseCor="9.6546810160837798E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S16" upshifts 25248 /Source="Nicolas_upshifts" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="upshifts" promotor_-10 complement(25382..25400) /Source="Nicolas_upshift_promotors" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(25401) /Source="Nicolas_upshifts" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(25415..25421) /Source="Nicolas_upshift_promotors" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 25443..25928 /gene="tadA" /locus_tag="BSU_00180" /old_locus_tag="BSU00180" /EC_number="3.5.4.33" /function="10.3: tRNA and rRNA base modification" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15677468, 16014871, 16415880, 16700551, 23658230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA specific adenosine A34 deaminase" /protein_id="NP_387899.1" /db_xref="EnsemblGenomes-Gn:BSU00180" /db_xref="EnsemblGenomes-Tr:CAB11794" /db_xref="GOA:P21335" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR028883" /db_xref="SubtiList:BG10082" /db_xref="UniProtKB/Swiss-Prot:P21335" /translation="MTQDELYMKEAIKEAKKAEEKGEVPIGAVLVINGEIIARAHNLR ETEQRSIAHAEMLVIDEACKALGTWRLEGATLYVTLEPCPMCAGAVVLSRVEKVVFGA FDPKGGCSGTLMNLLQEERFNHQAEVVSGVLEEECGGMLSAFFRELRKKKKAARKNLS E*" /label="tadA CDS" gene 25443..25928 /gene="tadA" /locus_tag="BSU_00180" /old_locus_tag="BSU00180" /label="tadA gene" promotor_-35 25932..25938 /Source="Nicolas_upshift_promotors" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-35" promotor_-10 25952..25971 /Source="Nicolas_upshift_promotors" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-10" misc_RNA 25970..26323 /gene="scr" /locus_tag="BSU_misc_RNA_2" /product="small cytoplasmic RNA (scRNA, 4.5S RNA), signal recognition particle-like (SRP) component" /experiment="publication(s) with functional evidences, PMID:1372600, 1689715" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1372600, 1689715" /label="scr RNA" gene 25970..26323 /gene="scr" /locus_tag="BSU_misc_RNA_2" /label="scr gene" S_feature 25974..26123 /Source="Nicolas_S_feature" /locus_tag="new_26383_26532" /HighExp="T1.0H, T5.0H, T1.30H, T3.30H, T3.0H, T2.30H, T4.0H, S8, T-1.10H, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.899, 0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S17" upshifts 25974 /Source="Nicolas_upshifts" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="upshifts" S_feature 26227..26322 /Source="Nicolas_S_feature" /locus_tag="new_26636_26731" /HighExp="S8, Sw, B60, B36, T2.30H, T3.30H, T1.0H, BC, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.899, 0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S18" downshifts 26279 /Source="Nicolas_upshifts" /id="D11" /incds=0 /nref=273 /ntot=278 /MaxReadThrough="4.46774" /MaxDrop="8.31255" /score="23.257527" /energy="-10.3" /TU="U21,U23" /idTUdmin="U21" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 26343..26346 /Source="Nicolas_upshift_promotors" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-35" promotor_-10 26361..26380 /Source="Nicolas_upshift_promotors" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-10" upshifts 26370 /Source="Nicolas_upshifts" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="upshifts" CDS 26405..28096 /gene="dnaX" /locus_tag="BSU_00190" /old_locus_tag="BSU00190" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9341154, 10844689, 12466528, 12974630, 14757052, 15927750, 25850333, 26786318" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9341154, 10844689, 12466528, 12974630, 14757052, 15927750, 25850333, 26786318; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III subunit tau subunit" /protein_id="NP_387900.2" /db_xref="EnsemblGenomes-Gn:BSU00190" /db_xref="EnsemblGenomes-Tr:CAB11795" /db_xref="GOA:P09122" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR012763" /db_xref="InterPro:IPR022754" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10083" /db_xref="UniProtKB/Swiss-Prot:P09122" /translation="MSYQALYRVFRPQRFEDVVGQEHITKTLQNALLQKKFSHAYLFS GPRGTGKTSAAKIFAKAVNCEHAPVDEPCNECAACKGITNGSISDVIEIDAASNNGVD EIRDIRDKVKFAPSAVTYKVYIIDEVHMLSIGAFNALLKTLEEPPEHCIFILATTEPH KIPLTIISRCQRFDFKRITSQAIVGRMNKIVDAEQLQVEEGSLEIIASAADGGMRDAL SLLDQAISFSGDILKVEDALLITGAVSQLYIGKLAKSLHDKNVSDALETLNELLQQGK DPAKLIEDMIFYFRDMLLYKTAPGLEGVLEKVKVDETFRELSEQIPAQALYEMIDILN KSHQEMKWTNHPRIFFEVAVVKICQTSHQSAADLPEVDMLMKKIQQLEQEVERLKTTG IKAAAESPKKEAPRVPKGGKSNYKAPVGRIHEILKEATRPDLDLLRNSWGKLLAHLKQ QNKVSHAALLNDSEPVAAGSAAFVLKFKYEIHCKMVAEDNNGVRTNLEQILESMLGKR MDLIGVPEAQWGKIREEFLEDHQQENEGSNEPAEEDPLIAEAKKLVGADLIEIKD*" /label="dnaX CDS" gene 26405..28096 /gene="dnaX" /locus_tag="BSU_00190" /old_locus_tag="BSU00190" /label="dnaX gene" promotor_-35 27937..27944 /Source="Nicolas_upshift_promotors" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-35" promotor_-10 27959..27978 /Source="Nicolas_upshift_promotors" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-10" upshifts 27974 /Source="Nicolas_upshifts" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="upshifts" CDS 28120..28443 /gene="ebfC" /locus_tag="BSU_00200" /old_locus_tag="BSU00200" /function="16.9: Replicate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16740939, 19208644, 19594923, 20639362, 22333191, 22544270; Product type f : factor" /codon_start=1 /transl_table=11 /product="nucleoid associated protein" /protein_id="NP_387901.1" /db_xref="EnsemblGenomes-Gn:BSU00200" /db_xref="EnsemblGenomes-Tr:CAB11796" /db_xref="GOA:P24281" /db_xref="InterPro:IPR004401" /db_xref="InterPro:IPR036894" /db_xref="SubtiList:BG10084" /db_xref="UniProtKB/Swiss-Prot:P24281" /translation="MRGGMGNMQKMMKQMQKMQKDMAKAQEELAEKVVEGTAGGGMVT VKANGQKEILDVIIKEEVVDPEDIDMLQDLVLAATNEALKKVDEITNETMGQFTKGMN MPGLF*" /label="ebfC CDS" gene 28120..28443 /gene="ebfC" /locus_tag="BSU_00200" /old_locus_tag="BSU00200" /label="ebfC gene" CDS 28458..29054 /gene="recR" /locus_tag="BSU_00210" /old_locus_tag="BSU00210" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12065426, 24285298, 24891441" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065426, 24285298, 24891441; Product type f: factor" /codon_start=1 /transl_table=11 /product="recA filament-DNA complex stabilisation factor" /protein_id="NP_387902.1" /db_xref="EnsemblGenomes-Gn:BSU00210" /db_xref="EnsemblGenomes-Tr:CAB11797" /db_xref="GOA:P24277" /db_xref="InterPro:IPR000093" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR015967" /db_xref="InterPro:IPR023170" /db_xref="InterPro:IPR023627" /db_xref="InterPro:IPR023628" /db_xref="InterPro:IPR034137" /db_xref="SubtiList:BG10085" /db_xref="UniProtKB/Swiss-Prot:P24277" /translation="MQYPEPISKLIDSFMKLPGIGPKTAVRLAFFVLGMKEDVVLDFA KALVNAKRNLTYCSVCGHITDQDPCYICEDTRRDKSVICVVQDPKDVIAMEKMKEYNG QYHVLHGAISPMDGIGPEDIKIPELLKRLQDDQVTEVILATNPNIEGEATAMYISRLL KPSGIKLSRIAHGLPVGGDLEYADEVTLSKALEGRREL*" /label="recR CDS" gene 28458..29054 /gene="recR" /locus_tag="BSU_00210" /old_locus_tag="BSU00210" /label="recR gene" CDS 29072..29296 /gene="yaaL" /locus_tag="BSU_00220" /old_locus_tag="BSU00220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387903.1" /db_xref="EnsemblGenomes-Gn:BSU00220" /db_xref="EnsemblGenomes-Tr:CAB11798" /db_xref="InterPro:IPR019644" /db_xref="SubtiList:BG10086" /db_xref="UniProtKB/Swiss-Prot:P37533" /translation="MGFLRKKTLRREFDEKLTEQLFKQKEEWNRQKKLVEKSLEPSAE VLYELKVAEAKYFFYLREAKQRNLKISRWK*" /label="yaaL CDS" gene 29072..29296 /gene="yaaL" /locus_tag="BSU_00220" /old_locus_tag="BSU00220" /label="yaaL gene" promotor_-35 29299..29304 /Source="Nicolas_upshift_promotors" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="promotor_-35" upshifts 29316 /Source="Nicolas_upshifts" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="upshifts" promotor_-10 29320..29338 /Source="Nicolas_upshift_promotors" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="promotor_-10" CDS 29363..29626 /gene="bofA" /locus_tag="BSU_00230" /old_locus_tag="BSU00230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15087499, 17557826" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15087499, 17557826; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of the pro-sigma(K) processing machinery" /protein_id="NP_387904.2" /db_xref="EnsemblGenomes-Gn:BSU00230" /db_xref="EnsemblGenomes-Tr:CAB11799" /db_xref="GOA:P24282" /db_xref="InterPro:IPR010001" /db_xref="SubtiList:BG10087" /db_xref="UniProtKB/Swiss-Prot:P24282" /translation="MEPIFIIGIILGLVILLFLSGSAAKPLKWIGITAVKFVAGALLL VCVNMFGGSLGIHVPINLVTTAISGILGIPGIAALVVIKQFII*" /label="bofA CDS" gene 29363..29626 /gene="bofA" /locus_tag="BSU_00230" /old_locus_tag="BSU00230" /label="bofA gene" promotor_-35 29639..29646 /Source="Nicolas_upshift_promotors" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 29660..29679 /Source="Nicolas_upshift_promotors" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 29667..29869 /Source="Nicolas_S_feature" /locus_tag="new_30076_30278" /HighExp="LBGstat, Diami, C30, H2O2, Oxctl, HPh, BMM, GM 120, Paraq, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 1" /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.999, 1, 0.899, 0.99" /label="S19" upshifts 29667 /Source="Nicolas_upshifts" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="upshifts" rRNA 29870..31423 /gene="rrnA-16S" /locus_tag="BSU_rRNA_4" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnA-16S" gene 29870..31423 /gene="rrnA-16S" /locus_tag="BSU_rRNA_4" /label="rrnA-16S gene" tRNA 31523..31599 /gene="trnA-Ile" /locus_tag="BSU_tRNA_8" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ile(GAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnA-Ile" gene 31523..31599 /gene="trnA-Ile" /locus_tag="BSU_tRNA_8" /label="trnA-Ile gene" tRNA 31611..31686 /gene="trnA-Ala" /locus_tag="BSU_tRNA_9" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnA-Ala" gene 31611..31686 /gene="trnA-Ala" /locus_tag="BSU_tRNA_9" /label="trnA-Ala gene" rRNA 31768..34694 /gene="rrnA-23S" /locus_tag="BSU_rRNA_5" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnA-23S" gene 31768..34694 /gene="rrnA-23S" /locus_tag="BSU_rRNA_5" /label="rrnA-23S gene" S_feature 34695..34827 /Source="Nicolas_S_feature" /locus_tag="new_35104_35236" /HighExp="LBGstat, G135, Oxctl, C30, HPh, Paraq, G180, LPh, T0.30H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S20" rRNA 34828..34946 /gene="rrnA-5S" /locus_tag="BSU_rRNA_26" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnA-5S" gene 34828..34946 /gene="rrnA-5S" /locus_tag="BSU_rRNA_26" /label="rrnA-5S gene" S_feature 34947..35049 /Source="Nicolas_S_feature" /locus_tag="new_35356_35458" /HighExp="Oxctl, Paraq, H2O2, LBGstat, C30, G180, Cold, G135, Heat, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S21" promotor_-35 35010..35018 /Source="Nicolas_upshift_promotors" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="promotor_-35" promotor_-10 35032..35051 /Source="Nicolas_upshift_promotors" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="promotor_-10" upshifts 35051 /Source="Nicolas_upshifts" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="upshifts" CDS 35122..35316 /gene="csfB" /locus_tag="BSU_00240" /old_locus_tag="BSU00240" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8759874, 15044948, 21935351, 26929302" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759874, 15044948, 21935351, 26929302; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="forespore-specific anti-sigma factor" /protein_id="NP_387905.1" /db_xref="EnsemblGenomes-Gn:BSU00240" /db_xref="EnsemblGenomes-Tr:CAB11800" /db_xref="GOA:P37534" /db_xref="InterPro:IPR019700" /db_xref="SubtiList:BG10088" /db_xref="UniProtKB/Swiss-Prot:P37534" /translation="MDETVKLNHTCVICDQEKNRGIHLYTKFICLDCERKVISTSTSD PDYAFYVKKLKSIHTPPLYS*" /label="csfB CDS" gene 35122..35316 /gene="csfB" /locus_tag="BSU_00240" /old_locus_tag="BSU00240" /label="csfB gene" downshifts 35300 /Source="Nicolas_upshifts" /id="D12" /incds=0 /nref=79 /ntot=215 /MaxReadThrough="5.37774" /MaxDrop="4.42494" /score="22.3916007" /energy="-6.7" /TU="U28" /idTUdmin="U27" /TUdmin=3938 /isTUend="FALSE" /label="downshifts" promotor_-35 35361..35370 /Source="Nicolas_upshift_promotors" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 35382..35397 /Source="Nicolas_upshift_promotors" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 35388 /Source="Nicolas_upshifts" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="upshifts" CDS 35436..36050 /gene="xpaC" /locus_tag="BSU_00250" /old_locus_tag="BSU00250" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23155385; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatase" /protein_id="NP_387906.1" /db_xref="EnsemblGenomes-Gn:BSU00250" /db_xref="EnsemblGenomes-Tr:CAB11801" /db_xref="GOA:P37467" /db_xref="InterPro:IPR018770" /db_xref="SubtiList:BG10089" /db_xref="UniProtKB/Swiss-Prot:P37467" /translation="MQRFFHFLVWSLTSSATFVFIGILSFFGLNQSIFLSIVYGLASG AAVYIAGIWNARRLFLKKHELTGREYAYIKKNLEEARQKMVRLRKALFQAKSIQMFKQ NAEMLRIVRRIYLLTKKEPKRFYQAERFFYQTLDSVVELTEKYAFLSSHPKKSKELSM SLSETRITLTELTKRLEEDLTQAMGDEIDELQFELDAAKHSLKK*" /label="xpaC CDS" gene 35436..36050 /gene="xpaC" /locus_tag="BSU_00250" /old_locus_tag="BSU00250" /label="xpaC gene" CDS 36069..37229 /gene="yaaN" /locus_tag="BSU_00260" /old_locus_tag="BSU00260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12533473, 20713661" /codon_start=1 /transl_table=11 /product="putative toxic compound resistance protein" /protein_id="NP_387907.1" /db_xref="EnsemblGenomes-Gn:BSU00260" /db_xref="EnsemblGenomes-Tr:CAB11802" /db_xref="InterPro:IPR008863" /db_xref="SubtiList:BG10090" /db_xref="UniProtKB/Swiss-Prot:P37535" /translation="MNRDQSDLHIDELLADPFGGNIEIPGSEAVKAEKEQVRLVDVLP EENKEKAIQLAGQIDHKNMQSIVLYGSQAQSKLLNFSHDMINHVQKKDVGEIGEILGE LMKKLEQVNPDDLQSKKKGFLARMFGRVSSSLQEVLSKYQKTSVQIDRISLKLEHSKN ALISDNKLLEQLYEKNKEYFAALNVYIAAGELKLEELKTKTIPELKQQAESSDHNQMA VQEVNDLIQFADRLDKRVHDLLLSRQITIQSAPQIRLIQNTNQALAEKIQSSIVTAIP LWKNQVAIALTLLRQRNAVDAQQKVSDTTNELLLKNAELLKTNTIETARANERGLVDI DTLKKVQESLISTLEETLTIQEEGRIKRRQAEEELMMMEGDLKQKLITIKER*" /label="yaaN CDS" gene 36069..37229 /gene="yaaN" /locus_tag="BSU_00260" /old_locus_tag="BSU00260" /label="yaaN gene" S_feature 37230..37310 /Source="Nicolas_S_feature" /locus_tag="new_37639_37719" /HighExp="T0.0H, T-0.40H, T0.30H, T-1.10H, T-1.40H, Salt, T1.0H, G150, Diami, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigK" /TUshortPSig="0.984, 0.715" /TUlongSig="NA" /TUlongPSig="NA" /label="S22" CDS 37311..38753 /gene="yaaO" /locus_tag="BSU_00270" /old_locus_tag="BSU00270" /EC_number="4.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9723923, 20876533, 24529384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative decarboxylase" /protein_id="NP_387908.1" /db_xref="EnsemblGenomes-Gn:BSU00270" /db_xref="EnsemblGenomes-Tr:CAB11803" /db_xref="GOA:P37536" /db_xref="InterPro:IPR000310" /db_xref="InterPro:IPR008286" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036633" /db_xref="SubtiList:BG10091" /db_xref="UniProtKB/Swiss-Prot:P37536" /translation="MNTPLYKALIQHARRNSHSFHVPGHHNGDVFFDDAKSIFDPLLT IDVTELAGLDDLHHPSGVIKEAQELASQLYGSAESFFLVNGTTVGNLAMILSVCEPGD TILVQRNCHKSVFHAVDLSGAEPVYLAPDVDSAMHVPTHVPLGTIKEALEAYPDAKGL VLTNPTYYGHSADLTEIITEAHHYGIPVLVDEAHGAHFILGEPFPVSALKMGADIVVQ SAHKTLPAMTMGSYLHLNSSCRINRDRVAEYLNRLQSSSPSYPIMASLDIARAYVQHI IEEQKLSDILQRIETLKQTFDSLTNAEAVNPANPLIITDPLKLTIRSKRGHSGYTLQS ILERANIFTELADENQVLLVLPLGGKRRINAEIIRSIDEEIEKTPPDQTFVSAEWGVQ PVTVLPYPKKVLHSFKKEYVSFEEAAGRLNAEDIIPYPPGIPMIMAGERITKESVQKL SRLISMKTHVQGNMKIKEKQLLVYIEEEKS*" /label="yaaO CDS" gene 37311..38753 /gene="yaaO" /locus_tag="BSU_00270" /old_locus_tag="BSU00270" /label="yaaO gene" promotor_-35 38673..38679 /Source="Nicolas_upshift_promotors" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="promotor_-35" promotor_-10 38694..38712 /Source="Nicolas_upshift_promotors" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="promotor_-10" upshifts 38703 /Source="Nicolas_upshifts" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="upshifts" CDS 38750..39388 /gene="tmk" /locus_tag="BSU_00280" /old_locus_tag="BSU00280" /EC_number="2.7.4.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9696781, 12682299, 18523102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696781, 12682299, 18523102; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate kinase" /protein_id="NP_387909.2" /db_xref="EnsemblGenomes-Gn:BSU00280" /db_xref="EnsemblGenomes-Tr:CAB11804" /db_xref="GOA:P37537" /db_xref="InterPro:IPR018094" /db_xref="InterPro:IPR018095" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10092" /db_xref="UniProtKB/Swiss-Prot:P37537" /translation="MSGLFITFEGPEGAGKTTVLQEIKNILTAEGLQVMATREPGGID IAEQIREVILNENNILMDPKTEALLYAAARRQHLVEKVKPALEQGFIVLCDRFIDSSL AYQGYARGLGIDEVLSINEFAIGDMMPHVTVYFSIDPEEGLKRIYANGSREKNRLDLE KLDFHTKVQEGYQELMKRFPERFHSVDAGQSKDLVVQDVLKVIDEALKKIQL*" /label="tmk CDS" gene 38750..39388 /gene="tmk" /locus_tag="BSU_00280" /old_locus_tag="BSU00280" /label="tmk gene" promotor_-35 39383..39390 /Source="Nicolas_upshift_promotors" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 39403..39422 /Source="Nicolas_upshift_promotors" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 39414 /Source="Nicolas_upshifts" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="upshifts" CDS 39462..39791 /gene="darA" /locus_tag="BSU_00290" /old_locus_tag="BSU00290" /experiment="publication(s) with functional evidences, PMID:10913081, 25433025" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 25433025; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="signal transduction receptor, cyclic di-AMP binding" /protein_id="NP_387910.1" /db_xref="EnsemblGenomes-Gn:BSU00290" /db_xref="EnsemblGenomes-Tr:CAB11805" /db_xref="InterPro:IPR010375" /db_xref="InterPro:IPR011322" /db_xref="InterPro:IPR015867" /db_xref="PDB:4RLE" /db_xref="SubtiList:BG10093" /db_xref="UniProtKB/Swiss-Prot:P37538" /translation="MKLIVAVVQDQDSNRLLKTLTDHNFRVTKLATTGGFLKSGNTTF MIGVEDIRVNKALSLIKENGQKRDQMIAPVSPMGGNADSYVPYPVEVEVGGATVFVLP VDEFHQF*" /label="darA CDS" gene 39462..39791 /gene="darA" /locus_tag="BSU_00290" /old_locus_tag="BSU00290" /label="darA gene" CDS 39804..40244 /gene="yaaR" /locus_tag="BSU_00300" /old_locus_tag="BSU00300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_387911.1" /db_xref="EnsemblGenomes-Gn:BSU00300" /db_xref="EnsemblGenomes-Tr:CAB11806" /db_xref="InterPro:IPR005585" /db_xref="InterPro:IPR024042" /db_xref="SubtiList:BG10094" /db_xref="UniProtKB/Swiss-Prot:P37539" /translation="MKINKDIRTFIDNKQIPSVKTSEITASFKTSMENQSSKMKLDQL TRLLSDIEAFGKRLTKSRNFKDLARFKGLVKRFVKEAVDSGLSHETSKSFDLYGNSRT LGLVKEIDDKLIQLTEEMMDQEKPAIDLLERIGEIKGLLINLYT*" /label="yaaR CDS" gene 39804..40244 /gene="yaaR" /locus_tag="BSU_00300" /old_locus_tag="BSU00300" /label="yaaR gene" CDS 40256..41245 /gene="holB" /locus_tag="BSU_00310" /old_locus_tag="BSU00310" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8509334, 12060778, 12682299, 22333191, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8509334, 12060778, 12682299, 22333191, 23525462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III clamp loader delta' subunit" /protein_id="NP_387912.1" /db_xref="EnsemblGenomes-Gn:BSU00310" /db_xref="EnsemblGenomes-Tr:CAB11807" /db_xref="GOA:P37540" /db_xref="InterPro:IPR004622" /db_xref="InterPro:IPR015199" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10095" /db_xref="UniProtKB/Swiss-Prot:P37540" /translation="MAISWKEMNELQPRVMKLLYNSIEKDRLSHAYLFEGKKGTGKLD AALLLAKSFFCLEGGAEPCESCRNCKRIESGNHPDLHLVQPDGLSIKKAQIQALQEEF SKTGLESHKKLYIISHADQMTANAANSLLKFLEEPNKDTMAVLITEQPQRLLDTIISR CQTLPFQPLQPKAIEDRLIEQDVSPHMARLLANMTNNVAEAVELSRNDEFAESRAKVI KLYEVLHQRKGHAFFFIQDQWMPFFKEKTHQEMGLDMLLLIYRDVLSIQIGNEDKLIY QDLFQSIKQHALQSTQQSVTNQILAVLEAKKRLHSNVNVQGLMEHLVLMLQEG*" /label="holB CDS" gene 40256..41245 /gene="holB" /locus_tag="BSU_00310" /old_locus_tag="BSU00310" /label="holB gene" CDS 41248..42075 /gene="ricT" /locus_tag="BSU_00320" /old_locus_tag="BSU00320" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12270811, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12270811, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="subunit of a sporulation, competence and biofilmformation regulatory complex of RNaseY (RicAFT complex /FAD / two [4Fe-4S]2+)" /protein_id="NP_387913.1" /db_xref="EnsemblGenomes-Gn:BSU00320" /db_xref="EnsemblGenomes-Tr:CAB11808" /db_xref="GOA:P37541" /db_xref="InterPro:IPR007557" /db_xref="SubtiList:BG10096" /db_xref="UniProtKB/Swiss-Prot:P37541" /translation="MYNVIGVRFKKAGKIYYFDPNGFHIEHDSCVIVETVRGVEYGQV VIANKQVDEHDVVLPLRKVIRVADDRDLLIVEENKQEALSAFDICQKKVIEHGLDMKL VDVEFTFDRNKVIFYFTADGRVDFRELVKDLASIFKTRIELRQIGVRDEAKMLGGIGP CGRMLCCSTFLGDFEPVSIKMAKDQNLSLNPTKISGLCGRLMCCLKYENDEYETAKEQ LPDIGEMITTANGPAKVVGLNILERVLQVELINREKVIEYTWEELLEEGVVSAQTTD* " /label="ricT CDS" gene 41248..42075 /gene="ricT" /locus_tag="BSU_00320" /old_locus_tag="BSU00320" /label="ricT gene" CDS 42090..42449 /gene="dnaH" /locus_tag="BSU_00330" /old_locus_tag="BSU00330" /function="16.9: Replicate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15927750, 16461910, 19737352, 21895792, 23909787, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15927750, 16461910, 19737352, 21895792, 23909787, 28166228; Product type f : factor" /codon_start=1 /transl_table=11 /product="subunit of the DNA replication complex" /protein_id="NP_387914.1" /db_xref="EnsemblGenomes-Gn:BSU00330" /db_xref="EnsemblGenomes-Tr:CAB11809" /db_xref="GOA:P37542" /db_xref="InterPro:IPR010377" /db_xref="PDB:5DOL" /db_xref="SubtiList:BG10097" /db_xref="UniProtKB/Swiss-Prot:P37542" /translation="MDKKELFDTVINLEEQIGSLYRQLGDLKQHIGEMIEENHHLQLE NKHLRKRLDDTTQQIEKFKADKKESKTQKTEQTDIGEGYDNLARLYQEGFHICNVHYG SVRKEDCLFCLSFLNKK*" /label="dnaH CDS" gene 42090..42449 /gene="dnaH" /locus_tag="BSU_00330" /old_locus_tag="BSU00330" /label="dnaH gene" CDS 42508..43251 /gene="trmNF" /locus_tag="BSU_00340" /old_locus_tag="BSU00340" /EC_number="2.1.1.223" /function="10.3: tRNA and rRNA base modification" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22905870, 24809820; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA1(Val) (adenine(37)-N6)-methyltransferase" /protein_id="NP_387915.1" /db_xref="EnsemblGenomes-Gn:BSU00340" /db_xref="EnsemblGenomes-Tr:CAB11810" /db_xref="GOA:P37543" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10098" /db_xref="UniProtKB/Swiss-Prot:P37543" /translation="MVSLHDDERLDYLLAEDMKIIQSPTVFAFSLDAVLLSKFAYVPI QKGKIVDLCTGNGIVPLLLSTRSKADILGVEIQERLHDMAVRSVEYNKLDDQIQIIHD DLKNMPEKLGHNRYDVVTCNPPYFKTPKQTEQNMNEHLRIARHEIHCTLEDVISVSSK LLKQGGKAALVHRPGRLLEIFELMKAYQIEPKRVQFVYPKQGKEANTILVEGIKGGRP DLKILPPLFVYDEQNEYTKEIRTILYGDK*" /label="trmNF CDS" gene 42508..43251 /gene="trmNF" /locus_tag="BSU_00340" /old_locus_tag="BSU00340" /label="trmNF gene" CDS 43238..43537 /gene="yazA" /locus_tag="BSU_00350" /old_locus_tag="BSU00350" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11483577; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UvrC-Intron-type (URI) endonuclease" /protein_id="NP_387916.1" /db_xref="EnsemblGenomes-Gn:BSU00350" /db_xref="EnsemblGenomes-Tr:CAB11811" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR035901" /db_xref="SubtiList:BG12700" /db_xref="UniProtKB/Swiss-Prot:O31414" /translation="METNNHFFYVVKCKDNSWYAGYTNDLHKRVKTHNDGKGAKYTKV RRPVELIFAESFSTKREAMQAEYYFKKLTRKKKELYIEEKRNSKEAVYVKAPNEL*" /label="yazA CDS" gene 43238..43537 /gene="yazA" /locus_tag="BSU_00350" /old_locus_tag="BSU00350" /label="yazA gene" CDS 43512..44390 /gene="rsmI" /locus_tag="BSU_00360" /old_locus_tag="BSU00360" /EC_number="2.1.1.198" /function="16.8: Protect" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 19965768, 25893373; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA 2'-O-ribose C1402 methyltransferase" /protein_id="NP_387917.1" /db_xref="EnsemblGenomes-Gn:BSU00360" /db_xref="EnsemblGenomes-Tr:CAB11812" /db_xref="GOA:P37544" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR008189" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR018063" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG10099" /db_xref="UniProtKB/Swiss-Prot:P37544" /translation="MLRRQMSFNGKSDMGILYLVPTPIGNLEDMTFRAIDTLKSVDAI AAEDTRQTKKLCHVYEIETPLVSYHEHNKESSGHKIIEWLKSGKNIALVSDAGLPTIS DPGAEIVKDFTDIGGYVVPLPGANAALTALIASGIVPQPFFFYGFLNRQKKEKKKELE ALKKRQETIIFYEAPHRLKETLSAMAEILGDREIAVTRELTKKYEEFIRGTISEVIGW ANEDQIRGEFCLVVEGSNNEEVDEEEQWWETLTAKEHVEHYISKGATSKEAIKKAAVD RNVPKREVYDAYHIKQ*" /label="rsmI CDS" gene 43512..44390 /gene="rsmI" /locus_tag="BSU_00360" /old_locus_tag="BSU00360" /label="rsmI gene" downshifts 44363 /Source="Nicolas_upshifts" /id="D13" /incds=0 /nref=23 /ntot=177 /MaxReadThrough="3.33195" /MaxDrop="3.72723" /score="5.97354542" /energy="-10.2" /TU="U29,U31" /idTUdmin="U29" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(44439..44729) /gene="abrB" /locus_tag="BSU_00370" /old_locus_tag="BSU00370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10754235, 10809710, 11101881, 11101897, 16159768, 16223496, 16702211, 25308864, 25381239, 18676675, 22183144, 23196984, 24832089, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10754235, 10809710, 11101881, 11101897, 16159768, 16223496, 16702211, 25308864, 25381239, 18676675, 22183144, 23196984, 24832089, 24847778, 25288929; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for transition state genes (AbrB-SurF)" /protein_id="NP_387918.1" /db_xref="EnsemblGenomes-Gn:BSU00370" /db_xref="EnsemblGenomes-Tr:CAB11813" /db_xref="GOA:P08874" /db_xref="InterPro:IPR007159" /db_xref="PDB:1YFB" /db_xref="PDB:1YSF" /db_xref="PDB:1Z0R" /db_xref="PDB:2K1N" /db_xref="PDB:2MJG" /db_xref="PDB:2RO4" /db_xref="SubtiList:BG10100" /db_xref="UniProtKB/Swiss-Prot:P08874" /translation="MFMKSTGIVRKVDELGRVVIPIELRRTLGIAEKDALEIYVDDEK IILKKYKPNMTCQVTGEVSDDNLKLAGGKLVLSKEGAEQIISEIQNQLQNLK*" /label="abrB CDS" gene complement(44439..44729) /gene="abrB" /locus_tag="BSU_00370" /old_locus_tag="BSU00370" /label="abrB gene" downshifts complement(44441) /Source="Nicolas_upshifts" /id="D14" /incds=0 /nref=216 /ntot=263 /MaxReadThrough="2.17237" /MaxDrop="7.75729" /score="20.9582436" /energy="-10.2" /TU="U32" /idTUdmin="U32" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" downshifts 44760 /Source="Nicolas_upshifts" /id="D15" /incds=0 /nref=1 /ntot=15 /MaxReadThrough="2.53543" /MaxDrop="4.31699" /score="13.7153159" /energy="-14.4" /TU="NA" /idTUdmin="U29" /TUdmin=374 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(44796..44815) /Source="Nicolas_upshift_promotors" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(44813) /Source="Nicolas_upshifts" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(44815..44990) /Source="Nicolas_S_feature" /locus_tag="new_45224_45399_c" /HighExp="C30, H2O2, G180, Etha, S0, GM 25, Gly, G135, MG 25, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S23" promotor_-35 complement(44829..44836) /Source="Nicolas_upshift_promotors" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(44986..45005) /Source="Nicolas_upshift_promotors" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="promotor_-10" upshifts complement(44990) /Source="Nicolas_upshifts" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="upshifts" promotor_-35 complement(45019..45026) /Source="Nicolas_upshift_promotors" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="promotor_-35" promotor_-35 45090..45094 /Source="Nicolas_upshift_promotors" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="promotor_-35" promotor_-10 45109..45128 /Source="Nicolas_upshift_promotors" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="promotor_-10" S_feature 45115..45223 /Source="Nicolas_S_feature" /locus_tag="new_45524_45632" /HighExp="LBGtran, Heat, dia5, dia15, LBGexp, Lbexp, dia0, H2O2, Diami, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S24" upshifts 45115 /Source="Nicolas_upshifts" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="upshifts" CDS 45224..47218 /gene="metS" /locus_tag="BSU_00380" /old_locus_tag="BSU00380" /EC_number="6.1.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11233169, 12682299, 12792655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionyl-tRNA synthetase" /protein_id="NP_387919.1" /db_xref="EnsemblGenomes-Gn:BSU00380" /db_xref="EnsemblGenomes-Tr:CAB11814" /db_xref="GOA:P37465" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR004495" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014758" /db_xref="InterPro:IPR015413" /db_xref="InterPro:IPR023457" /db_xref="InterPro:IPR033911" /db_xref="SubtiList:BG10101" /db_xref="UniProtKB/Swiss-Prot:P37465" /translation="MPQENNTFYITTPIYYPSGKLHIGHAYTTVAGDAMARYKRLKGF DVRYLTGTDEHGQKIQQKAEQENITPQEYVDRAAADIQKLWKQLEISNDDFIRTTEKR HKVVIEKVFQKLLDNGDIYLDEYEGWYSIPDETFYTETQLVDIERNEKGEVIGGKSPD SGHPVELIKEESYFFRMGKYADRLLKYYEENPTFIQPESRKNEMINNFIKPGLEDLAV SRTTFDWGVKVPENPKHVVYVWIDALFNYLTALGYDTENDELYQKYWPADVHLVGKEI VRFHTIYWPIMLMALDLPLPKQVFAHGWLLMKDGKMSKSKGNVVDPVTLIERYGLDEL RYYLLREVPFGSDGVFTPEGFVERINYDLANDLGNLLNRTVAMINKYFDGQIGSYKGA VTEFDHTLTSVAEETVKAYEKAMENMEFSVALSTLWQLISRTNKYIDETAPWVLAKDP AKEEELRSVMYHLAESLRISAVLLQPFLTKTPEKMFEQLGITDESLKAWDSITAFGQL KDTKVQKGEPLFPRLEAEEEIAYIKGKMQGSAPAKEETKEEEPQEVDRLPEITIDQFM DVELRVAEVIEAEPVKKADRLLKLQLDLGFEKRQVVSGIAKHYTPEELVGKKLVCVTN LKPVKLRGELSQGMILAGEADGVLKVVSIDQSLPKGTRIK*" /label="metS CDS" gene 45224..47218 /gene="metS" /locus_tag="BSU_00380" /old_locus_tag="BSU00380" /label="metS gene" promotor_-10 complement(45972..45991) /Source="Nicolas_upshift_promotors" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(45980) /Source="Nicolas_upshifts" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(46007..46011) /Source="Nicolas_upshift_promotors" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 47202 /Source="Nicolas_upshifts" /id="D16" /incds=0 /nref=18 /ntot=206 /MaxReadThrough="4.8491" /MaxDrop="2.9167" /score="13.7153159" /energy="-14.4" /TU="U34" /idTUdmin="U34" /TUdmin="-2288" /isTUend="FALSE" /label="downshifts" S_feature complement(47264..49610) /Source="Nicolas_S_feature" /locus_tag="new_47673_50019_c" /HighExp="T0.30H, T1.0H, T1.30H, Salt, C30, T2.0H, T-0.40H, T0.0H, T2.30H, T-1.10H" /AntisenseName="yabE" /AntisenseCor="-0.28154713646185298" /AntisenseRegPval="-5.6" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S25" CDS 47297..48064 /gene="dayD" /locus_tag="BSU_00390" /old_locus_tag="BSU00390" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10747959, 16014871, 16461678, 19332551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-amino acyl-tRNA deacylase" /protein_id="NP_387920.1" /db_xref="EnsemblGenomes-Gn:BSU00390" /db_xref="EnsemblGenomes-Tr:CAB11815" /db_xref="GOA:P37545" /db_xref="InterPro:IPR001130" /db_xref="InterPro:IPR015991" /db_xref="InterPro:IPR018228" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG10102" /db_xref="UniProtKB/Swiss-Prot:P37545" /translation="MLFDTHAHLNAEQYDTDLEEVIERAKAEKVERIVVVGFDRPTIT RAMEMIEEYDFIYAAIGWHPVDAIDMTEEDLAWIKELSAHEKVVAIGEMGLDYHWDKS PKDIQKEVFRNQIALAKEVNLPIIIHNRDATEDVVTILKEEGAEAVGGIMHCFTGSAE VARECMKMNFYLSFGGPVTFKNAKKPKEVVKEIPNDRLLIETDCPFLTPHPFRGKRNE PSYVKYVAEQIAELKEMTFEEIASITTENAKRLFRIN*" /label="dayD CDS" gene 47297..48064 /gene="dayD" /locus_tag="BSU_00390" /old_locus_tag="BSU00390" /label="dayD gene" S_feature 48065..48145 /Source="Nicolas_S_feature" /locus_tag="new_48474_48554" /HighExp="Heat, C30, LBGtran, LBGstat, C90, Etha, M40t45, LPhT, MG 15, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S26" promotor_-35 48122..48127 /Source="Nicolas_upshift_promotors" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 48143..48161 /Source="Nicolas_upshift_promotors" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 48147 /Source="Nicolas_upshifts" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 48172..48175 /Source="Nicolas_upshift_promotors" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="promotor_-35" promotor_-10 48190..48209 /Source="Nicolas_upshift_promotors" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="promotor_-10" upshifts 48207 /Source="Nicolas_upshifts" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="upshifts" CDS 48220..49533 /gene="yabE" /locus_tag="BSU_00400" /old_locus_tag="BSU00400" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15774001, 19047346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cell wall shaping enzyme" /protein_id="NP_387921.1" /db_xref="EnsemblGenomes-Gn:BSU00400" /db_xref="EnsemblGenomes-Tr:CAB11816" /db_xref="GOA:P37546" /db_xref="InterPro:IPR007137" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR011098" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG10103" /db_xref="UniProtKB/Swiss-Prot:P37546" /translation="MGEREGRVDSLLDTLYNLSEEKEAFFITQKMKKLFSVKLSKSKV ILVAACLLLAGSGTAYAAHELTKQSVSVSINGKKKHIRTHANTVGDLLETLDIKTRDE DKITPAKQTKITADMDVVYEAAKPVKLTINGEEKTLWSTAKTVGALLDEQDVDVKEQD QIDPAIDTDISKDMKINIEPAFQVTVNDAGKQKKIWTTSTTVADFLKQQKMNIKDEDK IKPALDAKLTKGKADITITRIEKVTDVVEEKIAFDVKKQEDASLEKGKEKVVQKGKEG KLKKHFEVVKENGKEVSRELVKEETAEQSKDKVIAVGTKQSSPKFETVSASGDSKTVV SRSNESTGKVMTVSSTAYTASCSGCSGHTATGVNLKNNPNAKVIAVDPNVIPLGSKVH VEGYGYAIAADTGSAIKGNKIDVFFPEKSSAYRWGNKTVKIKILN*" /label="yabE CDS" gene 48220..49533 /gene="yabE" /locus_tag="BSU_00400" /old_locus_tag="BSU00400" /label="yabE gene" promotor_-35 48240..48247 /Source="Nicolas_upshift_promotors" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 48258 /Source="Nicolas_upshifts" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 48262..48281 /Source="Nicolas_upshift_promotors" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 49494 /Source="Nicolas_upshifts" /id="D17" /incds=0 /nref=87 /ntot=220 /MaxReadThrough="5.02755" /MaxDrop="4.87493" /score="27.529638" /energy="-11.3" /TU="U36,U37,U38" /idTUdmin="U34" /TUdmin=4 /isTUend="TRUE" /label="downshifts" promotor_-35 49556..49560 /Source="Nicolas_upshift_promotors" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 49576..49595 /Source="Nicolas_upshift_promotors" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 49578..49677 /Source="Nicolas_S_feature" /locus_tag="new_49987_50086" /HighExp="LoTm, H2O2, G180, G135, G150, Paraq, Oxctl, C30, dia15, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigEF" /TUshortPSig="1, 1, 0.843, 0.943" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S27" upshifts 49578 /Source="Nicolas_upshifts" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(49602..49617) /Source="Nicolas_upshift_promotors" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(49618) /Source="Nicolas_upshifts" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(49629..49638) /Source="Nicolas_upshift_promotors" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 49674..49690 /Source="Nicolas_upshift_promotors" /id="U41" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=100 /SigmaFactorBS="aaaaagtttcatgaatatacaaaagtttttattttgtcttgg aggaAATAATGAAAATTAAAGagatcattgtggtcgaggggcgtgacgatacggcccg c" /listShort="rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 49678..50238 /gene="rnmV" /locus_tag="BSU_00410" /old_locus_tag="BSU00410" /EC_number="3.1.26.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11233981, 11976317, 12794188, 16077031" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11233981, 11976317, 12794188, 16077031; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease M5" /protein_id="NP_387922.1" /db_xref="EnsemblGenomes-Gn:BSU00410" /db_xref="EnsemblGenomes-Tr:CAB11817" /db_xref="GOA:P37547" /db_xref="InterPro:IPR004466" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR025156" /db_xref="InterPro:IPR034141" /db_xref="SubtiList:BG10104" /db_xref="UniProtKB/Swiss-Prot:P37547" /translation="MKIKEIIVVEGRDDTARIKLAVDADTIETNGSAIDDHVIDQIRL AQKTRGVIILTDPDFPGEKIRKTISEAVPGCKHAFLPKHLAKPKNKRGIGVEHASVES IRACLENVHEEMEAQPSDISAEDLIHAGLIGGPAAKCRRERLGDLLKIGYTNGKQLQK RLQMFQIKKSDFMSALDTVMREEQNE*" /label="rnmV CDS" gene 49678..50238 /gene="rnmV" /locus_tag="BSU_00410" /old_locus_tag="BSU00410" /label="rnmV gene" upshifts 49688 /Source="Nicolas_upshifts" /id="U41" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=100 /SigmaFactorBS="aaaaagtttcatgaatatacaaaagtttttattttgtcttgg aggaAATAATGAAAATTAAAGagatcattgtggtcgaggggcgtgacgatacggcccg c" /listShort="rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" CDS 50231..51109 /gene="rsmA" /locus_tag="BSU_00420" /old_locus_tag="BSU00420" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 99430, 6801425, 11327780, 1690648, 22391551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dimethyladenosine 16S ribosomal RNA transferase" /protein_id="NP_387923.1" /db_xref="EnsemblGenomes-Gn:BSU00420" /db_xref="EnsemblGenomes-Tr:CAB11818" /db_xref="GOA:P37468" /db_xref="InterPro:IPR001737" /db_xref="InterPro:IPR011530" /db_xref="InterPro:IPR020596" /db_xref="InterPro:IPR020598" /db_xref="InterPro:IPR023165" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10105" /db_xref="UniProtKB/Swiss-Prot:P37468" /translation="MNKDIATPIRTKEILKKYGFSFKKSLGQNFLIDTNILNRIVDHA EVTEKTGVIEIGPGIGALTEQLAKRAKKVVAFEIDQRLLPILKDTLSPYENVTVIHQD VLKADVKSVIEEQFQDCDEIMVVANLPYYVTTPIIMKLLEEHLPLKGIVVMLQKEVAE RMAADPSSKEYGSLSIAVQFYTEAKTVMIVPKTVFVPQPNVDSAVIRLILRDGPAVDV ENESFFFQLIKASFAQRRKTLLNNLVNNLPEGKAQKSTIEQVLEETNIDGKRRGESLS IEEFAALSNGLYKALF*" /label="rsmA CDS" gene 50231..51109 /gene="rsmA" /locus_tag="BSU_00420" /old_locus_tag="BSU00420" /label="rsmA gene" downshifts 51074 /Source="Nicolas_upshifts" /id="D18" /incds=0 /nref=152 /ntot=229 /MaxReadThrough="3.0815" /MaxDrop="4.58632" /score="20.4155562" /energy="-9.4" /TU="NA" /idTUdmin="U36" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 51124..51133 /Source="Nicolas_upshift_promotors" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 51147..51166 /Source="Nicolas_upshift_promotors" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 51149..51270 /Source="Nicolas_S_feature" /locus_tag="new_51558_51679" /HighExp="S7, S6, S8, BT, S5, B36, G/S, Pyr, B60, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S28" upshifts 51149 /Source="Nicolas_upshifts" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="upshifts" CDS 51271..52143 /gene="prtG" /locus_tag="BSU_00430" /old_locus_tag="BSU00430" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10714992, 11040425, 16751597, 19060142, 19833771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10714992, 11040425, 16751597, 19060142, 19833771; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protease" /protein_id="NP_387924.1" /db_xref="EnsemblGenomes-Gn:BSU00430" /db_xref="EnsemblGenomes-Tr:CAB11819" /db_xref="GOA:P37548" /db_xref="InterPro:IPR008764" /db_xref="SubtiList:BG10106" /db_xref="UniProtKB/Swiss-Prot:P37548" /translation="MQFQIGDMVARKSYQMDVLFRIIGIEQTSKGNSIAILHGDEVRL IADSDFSDLVAVKKDEQMMRKKKDESRMNESLELLRQDYKLLREKQEYYATSQYQHQE HYFHMPGKVLHLDGDEAYLKKCLNVYKKIGVPVYGIHCHEKKMSASIEVLLDKYRPDI LVITGHDAYSKQKGGIDDLNAYRHSKHFVETVQTARKKIPHLDQLVIFAGACQSHFES LIRAGANFASSPSRVNIHALDPVYIVAKISFTPFMERINVWEVLRNTLTREKGLGGIE TRGVLRIGMPYKSN*" /label="prtG CDS" gene 51271..52143 /gene="prtG" /locus_tag="BSU_00430" /old_locus_tag="BSU00430" /label="prtG gene" downshifts 52130 /Source="Nicolas_upshifts" /id="D19" /incds=0 /nref=15 /ntot=32 /MaxReadThrough="2.30424" /MaxDrop="7.1507" /score="26.6672651" /energy="-11.5" /TU="NA" /idTUdmin="U42" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 52240..52310 /Source="Nicolas_S_feature" /locus_tag="new_52649_52719" /HighExp="S8, S5, S7, S6, S4, BT, LoTm, G/S, nit, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S29" promotor_-35 52301..52308 /Source="Nicolas_upshift_promotors" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 52312 /Source="Nicolas_upshifts" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 52322..52341 /Source="Nicolas_upshift_promotors" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(52331..52345) /Source="Nicolas_upshift_promotors" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(52338) /Source="Nicolas_upshifts" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(52354..52358) /Source="Nicolas_upshift_promotors" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 52354..52614 /gene="veg" /locus_tag="BSU_00440" /old_locus_tag="BSU00440" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12761295, 22720735, 23378512; Producttype ph: phenotype" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_387925.1" /db_xref="EnsemblGenomes-Gn:BSU00440" /db_xref="EnsemblGenomes-Tr:CAB11820" /db_xref="GOA:P37466" /db_xref="InterPro:IPR009366" /db_xref="SubtiList:BG10107" /db_xref="UniProtKB/Swiss-Prot:P37466" /translation="MAKTLSDIKRSLDGNLGKRLTLKANGGRRKTIERSGILAETYPS VFVIQLDQDENSFERVSYSYADILTETVELTFNDDAASSVAF*" /label="veg CDS" gene 52354..52614 /gene="veg" /locus_tag="BSU_00440" /old_locus_tag="BSU00440" /label="veg gene" downshifts 52526 /Source="Nicolas_upshifts" /id="D20" /incds=1 /nref=4 /ntot=158 /MaxReadThrough="8.09861" /MaxDrop="2.7867" /score="12.4853319" /energy="-9.9" /TU="U43" /idTUdmin="U42" /TUdmin=396 /isTUend="FALSE" /label="downshifts" downshifts 52613 /Source="Nicolas_upshifts" /id="D21" /incds=0 /nref=191 /ntot=264 /MaxReadThrough="5.88511" /MaxDrop="6.03144" /score="12.4853319" /energy="-9.9" /TU="U43" /idTUdmin="U43" /TUdmin="-331" /isTUend="FALSE" /label="downshifts" promotor_-35 52679..52685 /Source="Nicolas_upshift_promotors" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 52699..52710 /Source="Nicolas_upshift_promotors" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 52702..52773 /Source="Nicolas_S_feature" /locus_tag="new_53111_53182" /HighExp="S8, Cold, S6, S7, ferm, S5, nit, Etha, G135, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.96, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S30" upshifts 52702 /Source="Nicolas_upshifts" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="upshifts" CDS 52774..52959 /gene="sspF" /locus_tag="BSU_00450" /old_locus_tag="BSU00450" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7959056, 8982008, 11092849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7959056, 8982008, 11092849; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha/beta-type SASP)" /protein_id="NP_387926.1" /db_xref="EnsemblGenomes-Gn:BSU00450" /db_xref="EnsemblGenomes-Tr:CAB11821" /db_xref="GOA:P37549" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10108" /db_xref="UniProtKB/Swiss-Prot:P37549" /translation="MGRRRGVMSDEFKYELAKDLGFYDTVKNGGWGEIRARDAGNMVK RAIEIAEQQMAQNQNNR*" /label="sspF CDS" gene 52774..52959 /gene="sspF" /locus_tag="BSU_00450" /old_locus_tag="BSU00450" /label="sspF gene" downshifts 52944 /Source="Nicolas_upshifts" /id="D22" /incds=0 /nref=54 /ntot=153 /MaxReadThrough="2.67408" /MaxDrop="6.21058" /score="38.1065567" /energy="-12.6" /TU="NA" /idTUdmin="U43" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(52954..55308) /Source="Nicolas_S_feature" /locus_tag="new_53363_55717_c" /HighExp="S5, S4, S6, T5.0H, S3, S8, S7, T4.0H, T3.30H, C30" /AntisenseName="ispE" /AntisenseCor="-0.66604185700913698" /AntisenseRegPval="-35.1" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S31" promotor_-35 53037..53041 /Source="Nicolas_upshift_promotors" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="promotor_-35" promotor_-10 53057..53076 /Source="Nicolas_upshift_promotors" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="promotor_-10" upshifts 53060 /Source="Nicolas_upshifts" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="upshifts" CDS 53107..53976 /gene="ispE" /locus_tag="BSU_00460" /old_locus_tag="BSU00460" /EC_number="2.7.1.148" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11361082, 12682299, 12771135, 17458547, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase" /protein_id="NP_387927.1" /db_xref="EnsemblGenomes-Gn:BSU00460" /db_xref="EnsemblGenomes-Tr:CAB11822" /db_xref="GOA:P37550" /db_xref="InterPro:IPR004424" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10109" /db_xref="UniProtKB/Swiss-Prot:P37550" /translation="MRILEKAPAKINLSLDVTRKRPDGYHEVEMIMTTIDLADRIELT ELAEDEVRVSSHNRFVPDDQRNLAYQAAKLIKDRYNVKKGVSIMITKVIPVAAGLAGG SSDAAATLRGLNRLWNLNLSAETLAELGAEIGSDVSFCVYGGTALATGRGEKIKHIST PPHCWVILAKPTIGVSTAEVYRALKLDGIEHPDVQGMIEAIEEKSFQKMCSRLGNVLE SVTLDMHPEVAMIKNQMKRFGADAVLMSGSGPTVFGLVQYESKVQRIYNGLRGFCDQV YAVRMIGEQNALD*" /label="ispE CDS" gene 53107..53976 /gene="ispE" /locus_tag="BSU_00460" /old_locus_tag="BSU00460" /label="ispE gene" CDS 54032..54889 /gene="purR" /locus_tag="BSU_00470" /old_locus_tag="BSU00470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11591660, 12837783, 12837784, 15629952, 16163456, 27329548" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591660, 12837783, 12837784, 15629952, 16163456, 27329548; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the purine biosynthesis operon (PurR-pRpp)" /protein_id="NP_387928.1" /db_xref="EnsemblGenomes-Gn:BSU00470" /db_xref="EnsemblGenomes-Tr:CAB11823" /db_xref="GOA:P37551" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR010078" /db_xref="InterPro:IPR015265" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1O57" /db_xref="PDB:1P4A" /db_xref="SubtiList:BG10110" /db_xref="UniProtKB/Swiss-Prot:P37551" /translation="MKFRRSGRLVDLTNYLLTHPHELIPLTFFSERYESAKSSISEDL TIIKQTFEQQGIGTLLTVPGAAGGVKYIPKMKQAEAEEFVQTLGQSLANPERILPGGY VYLTDILGKPSVLSKVGKLFASVFAEREIDVVMTVATKGIPLAYAAASYLNVPVVIVR KDNKVTEGSTVSINYVSGSSNRIQTMSLAKRSMKTGSNVLIIDDFMKAGGTINGMINL LDEFNANVAGIGVLVEAEGVDERLVDEYMSLLTLSTINMKEKSIEIQNGNFLRFFKDN LLKNGETES*" /label="purR CDS" gene 54032..54889 /gene="purR" /locus_tag="BSU_00470" /old_locus_tag="BSU00470" /label="purR gene" CDS 54886..55263 /gene="ridA" /locus_tag="BSU_00480" /old_locus_tag="BSU00480" /EC_number="3.5.99.10" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2113912, 12515541, 14729707, 10557275, 10919400, 10368157, 20562306, 23815688; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminoacrylate/iminopropionate hydrolase/deaminase" /protein_id="NP_387929.1" /db_xref="EnsemblGenomes-Gn:BSU00480" /db_xref="EnsemblGenomes-Tr:CAB11824" /db_xref="GOA:P37552" /db_xref="InterPro:IPR006056" /db_xref="InterPro:IPR006175" /db_xref="InterPro:IPR019897" /db_xref="InterPro:IPR035959" /db_xref="PDB:1QD9" /db_xref="SubtiList:BG10111" /db_xref="UniProtKB/Swiss-Prot:P37552" /translation="MTKAVHTKHAPAAIGPYSQGIIVNNMFYSSGQIPLTPSGEMVNG DIKEQTHQVFSNLKAVLEEAGASFETVVKATVFIADMEQFAEVNEVYGQYFDTHKPAR SCVEVARLPKDALVEIEVIALVK*" /label="ridA CDS" gene 54886..55263 /gene="ridA" /locus_tag="BSU_00480" /old_locus_tag="BSU00480" /label="ridA gene" downshifts 55253 /Source="Nicolas_upshifts" /id="D23" /incds=0 /nref=172 /ntot=226 /MaxReadThrough="3.8891" /MaxDrop="4.63425" /score="22.9159767" /energy="-12.3" /TU="U46" /idTUdmin="U46" /TUdmin="-155" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(55297..55315) /Source="Nicolas_upshift_promotors" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 55298..55406 /Source="Nicolas_S_feature" /locus_tag="new_55707_55815" /HighExp="S8, S7, Etha, B36, LoTm, C30, Sw, B60, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S32" upshifts complement(55309) /Source="Nicolas_upshifts" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(55331..55336) /Source="Nicolas_upshift_promotors" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 55386..55394 /Source="Nicolas_upshift_promotors" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="promotor_-35" promotor_-10 55405..55423 /Source="Nicolas_upshift_promotors" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="promotor_-10" upshifts 55408 /Source="Nicolas_upshifts" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="upshifts" CDS 55457..55750 /gene="spoVG" /locus_tag="BSU_00490" /old_locus_tag="BSU00490" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9733708, 10348850, 10648512, 16428420, 27048798" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733708, 10348850, 10648512, 16428420, 27048798; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator required for spore cortex synthesis (stage V sporulation)" /protein_id="NP_387930.1" /db_xref="EnsemblGenomes-Gn:BSU00490" /db_xref="EnsemblGenomes-Tr:CAB11825" /db_xref="GOA:P28015" /db_xref="InterPro:IPR007170" /db_xref="InterPro:IPR036751" /db_xref="PDB:2IA9" /db_xref="SubtiList:BG10112" /db_xref="UniProtKB/Swiss-Prot:P28015" /translation="MEVTDVRLRRVNTDGRMRAIASITLDHEFVVHDIRVIDGNNGLF VAMPSKRTPDGEFRDITHPINSSTRGKIQDAVLNEYHRLGDTEALEFEEAGAS*" /label="spoVG CDS" gene 55457..55750 /gene="spoVG" /locus_tag="BSU_00490" /old_locus_tag="BSU00490" /label="spoVG gene" downshifts 55739 /Source="Nicolas_upshifts" /id="D24" /incds=0 /nref=263 /ntot=285 /MaxReadThrough="5.11673" /MaxDrop="7.2673" /score="19.392304" /energy="-22.3" /TU="U48" /idTUdmin="U46" /TUdmin=331 /isTUend="FALSE" /label="downshifts" S_feature 55784..55895 /Source="Nicolas_S_feature" /locus_tag="new_56193_56304" /HighExp="B60, B36, M9-stat, S2, BT, LoTm, Etha, Lbstat, T0.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S33" promotor_-35 55877..55881 /Source="Nicolas_upshift_promotors" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 55897..55916 /Source="Nicolas_upshift_promotors" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 55897 /Source="Nicolas_upshifts" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" CDS 55943..57313 /gene="glmU" /locus_tag="BSU_00500" /old_locus_tag="BSU00500" /EC_number="2.3.1.157" /EC_number="2.7.7.23" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1328164, 8522540, 9648743, 11124906, 20495944, 23485416, 24915076" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1328164, 8522540, 9648743, 11124906, 20495944, 23485416, 24915076; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional glucosamine-1-phosphate N-acetyltransferase/UDP-N-acetylglucosamine pyrophosphorylase" /protein_id="NP_387931.1" /db_xref="EnsemblGenomes-Gn:BSU00500" /db_xref="EnsemblGenomes-Tr:CAB11826" /db_xref="GOA:P14192" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005882" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10113" /db_xref="UniProtKB/Swiss-Prot:P14192" /translation="MDKRFAVVLAAGQGTRMKSKLYKVLHPVCGKPMVEHVVDEALKL SLSKLVTIVGHGAEEVKKQLGDKSEYALQAKQLGTAHAVKQAQPFLADEKGVTIVICG DTPLLTAETMEQMLKEHTQREAKATILTAVAEDPTGYGRIIRSENGAVQKIVEHKDAS EEERLVTEINTGTYCFDNEALFRAIDQVSNDNAQGEYYLPDVIEILKNEGETVAAYQT GNFQETLGVNDRVALSQAEQFMKERINKRHMQNGVTLIDPMNTYISPDAVIGSDTVIY PGTVIKGEVQIGEDTIIGPHTEIMNSAIGSRTVIKQSVVNHSKVGNDVNIGPFAHIRP DSVIGNEVKIGNFVEIKKTQFGDRSKASHLSYVGDAEVGTDVNLGCGSITVNYDGKNK YLTKIEDGAFIGCNSNLVAPVTVGEGAYVAAGSTVTEDVPGKALAIARARQVNKDDYV KNIHKK*" /label="glmU CDS" gene 55943..57313 /gene="glmU" /locus_tag="BSU_00500" /old_locus_tag="BSU00500" /label="glmU gene" downshifts complement(57288) /Source="Nicolas_upshifts" /id="D25" /incds=0 /nref=5 /ntot=84 /MaxReadThrough="2.39379" /MaxDrop="3.65636" /score="-7.65702938" /energy="-13.8" /TU="NA" /idTUdmin="U47" /TUdmin="-4312" /isTUend="FALSE" /label="downshifts" CDS 57336..58289 /gene="prs" /locus_tag="BSU_00510" /old_locus_tag="BSU00510" /EC_number="2.7.6.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2169413, 3038693, 8522540, 22083279, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2169413, 3038693, 8522540, 22083279, 25890046; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylpyrophosphate synthetase" /protein_id="NP_387932.1" /db_xref="EnsemblGenomes-Gn:BSU00510" /db_xref="EnsemblGenomes-Tr:CAB11827" /db_xref="GOA:P14193" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR000842" /db_xref="InterPro:IPR005946" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR029099" /db_xref="PDB:1DKR" /db_xref="PDB:1DKU" /db_xref="PDB:1IBS" /db_xref="SubtiList:BG10114" /db_xref="UniProtKB/Swiss-Prot:P14193" /translation="MSNQYGDKNLKIFSLNSNPELAKEIADIVGVQLGKCSVTRFSDG EVQINIEESIRGCDCYIIQSTSDPVNEHIMELLIMVDALKRASAKTINIVIPYYGYAR QDRKARSREPITAKLFANLLETAGATRVIALDLHAPQIQGFFDIPIDHLMGVPILGEY FEGKNLEDIVIVSPDHGGVTRARKLADRLKAPIAIIDKRRPRPNVAEVMNIVGNIEGK TAILIDDIIDTAGTITLAANALVENGAKEVYACCTHPVLSGPAVERINNSTIKELVVT NSIKLPEEKKIERFKQLSVGPLLAEAIIRVHEQQSVSYLFS*" /label="prs CDS" gene 57336..58289 /gene="prs" /locus_tag="BSU_00510" /old_locus_tag="BSU00510" /label="prs gene" promotor_-35 58302..58308 /Source="Nicolas_upshift_promotors" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 58321 /Source="Nicolas_upshifts" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 58323..58341 /Source="Nicolas_upshift_promotors" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 58374..58988 /gene="ctc" /locus_tag="BSU_00520" /old_locus_tag="BSU00520" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8522540, 9669336, 10369900, 12432960, 17198710" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8522540, 9669336, 10369900, 12432960, 17198710; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein BL25 (Ctc), binding 5S RNA" /protein_id="NP_387933.1" /db_xref="EnsemblGenomes-Gn:BSU00520" /db_xref="EnsemblGenomes-Tr:CAB11828" /db_xref="GOA:P14194" /db_xref="InterPro:IPR001021" /db_xref="InterPro:IPR011035" /db_xref="InterPro:IPR020056" /db_xref="InterPro:IPR020057" /db_xref="InterPro:IPR029751" /db_xref="InterPro:IPR037121" /db_xref="SubtiList:BG10115" /db_xref="UniProtKB/Swiss-Prot:P14194" /translation="MATLTAKERTDFTRSSLRNIRTSGHVPGIIYGKDTGNKPVSLDS VELIKTLRDEGKNAVITLEVSGEKHSVMVTDLQTDPLKNEITHADFQVVNMSEDIEVE VPIHLTGEAIGVKNGGVLQQPLYALTVKAKPKAIPQTIEADISSLDVNEVLTIADLPA GGDYSFNHESDEVVASILPPQQQEAAEVDEEESADAQPEGENEQ*" /label="ctc CDS" gene 58374..58988 /gene="ctc" /locus_tag="BSU_00520" /old_locus_tag="BSU00520" /label="ctc gene" downshifts 58972 /Source="Nicolas_upshifts" /id="D26" /incds=0 /nref=120 /ntot=249 /MaxReadThrough="8.65206" /MaxDrop="5.4784" /score="1.94770319" /energy="-11.2" /TU="U49,U50" /idTUdmin="U48" /TUdmin=682 /isTUend="FALSE" /label="downshifts" CDS 59095..59661 /gene="pth" /locus_tag="BSU_00530" /old_locus_tag="BSU00530" /EC_number="3.1.1.29" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8635758, 12100553, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8635758, 12100553, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidyl-tRNA hydrolase" /protein_id="NP_387934.1" /db_xref="EnsemblGenomes-Gn:BSU00530" /db_xref="EnsemblGenomes-Tr:CAB11829" /db_xref="GOA:P37470" /db_xref="InterPro:IPR001328" /db_xref="InterPro:IPR018171" /db_xref="InterPro:IPR036416" /db_xref="SubtiList:BG10116" /db_xref="UniProtKB/Swiss-Prot:P37470" /translation="MLVIAGLGNPGKNYENTRHNVGFMVIDQLAKEWNIELNQNKFNG LYGTGFVSGKKVLLVKPLTYMNLSGECLRPLMDYYDVDNEDLTVIYDDLDLPTGKIRL RTKGSAGGHNGIKSLIQHLGTSEFDRIRIGIGRPVNGMKVVDYVLGSFTKEEAPEIEE AVDKSVKACEASLSKPFLEVMNEFNAKV*" /label="pth CDS" gene 59095..59661 /gene="pth" /locus_tag="BSU_00530" /old_locus_tag="BSU00530" /label="pth gene" misc_feature 59274..59277 /Source="Nicolas_upshift_promotors" /id="U51" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.210789210789211" /psig="0.210789210789211" /xcortree=737 /SigmaFactorBS="taacggattatacggaaccggatttgtttccggcaaaaaggt tctacttgttaaACCGcttacatatatgaatttatcaggagaatgtttgcggccttta a" /listShort="yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 59280 /Source="Nicolas_upshifts" /id="U51" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.210789210789211" /psig="0.210789210789211" /xcortree=737 /SigmaFactorBS="taacggattatacggaaccggatttgtttccggcaaaaaggt tctacttgttaaACCGcttacatatatgaatttatcaggagaatgtttgcggccttta a" /listShort="yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" CDS 59721..59951 /gene="fin" /locus_tag="BSU_00540" /old_locus_tag="BSU00540" /experiment="publication(s) with functional evidences, PMID:21037003, 28598017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21037003, 28598017; Product type f: factor" /codon_start=1 /transl_table=11 /product="protein required for the switch from F to G during sporulation (anti sigma F)" /protein_id="NP_387935.1" /db_xref="EnsemblGenomes-Gn:BSU00540" /db_xref="EnsemblGenomes-Tr:CAB11830" /db_xref="GOA:P37553" /db_xref="InterPro:IPR020115" /db_xref="PDB:5MSL" /db_xref="SubtiList:BG10117" /db_xref="UniProtKB/Swiss-Prot:P37553" /translation="MALHYYCRHCGVKVGSLESSMVSTDSLGFQHLTNEERNDMISYK ENGDVHVLTICEDCQEALDRNPHYHEYHTFIQ*" /label="fin CDS" gene 59721..59951 /gene="fin" /locus_tag="BSU_00540" /old_locus_tag="BSU00540" /label="fin gene" S_feature 59952..60020 /Source="Nicolas_S_feature" /locus_tag="new_60361_60429" /HighExp="Etha, S5, S4, S7, S8, S6, S3, H2O2, Diami, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigB, SigA" /TUshortPSig="0.211, 1, 0.996" /TUlongSig="SigH" /TUlongPSig=1 /label="S34" CDS 60021..63554 /gene="mfd" /locus_tag="BSU_00550" /old_locus_tag="BSU00550" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8594198, 9535092, 11065368, 16950921, 22248542, 25713353, 27399782, 27435260" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8594198, 9535092, 11065368, 16950921, 22248542, 25713353, 27399782, 27435260; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription-repair coupling factor" /protein_id="NP_387936.1" /db_xref="EnsemblGenomes-Gn:BSU00550" /db_xref="EnsemblGenomes-Tr:CAB11831" /db_xref="GOA:P37474" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR003711" /db_xref="InterPro:IPR004576" /db_xref="InterPro:IPR005118" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036101" /db_xref="SubtiList:BG10118" /db_xref="UniProtKB/Swiss-Prot:P37474" /translation="MDNIQTFIKESDDFKSIINGLHEGLKEQLLAGLSGSARSVFTSA LANETNKPIFLITHNLYQAQKVTDDLTSLLEDRSVLLYPVNELISSEIAVASPELRAQ RLDVINRLTNGEAPIVVAPVAAIRRMLPPVEVWKSSQMLIQVGHDIEPDQLASRLVEV GYERSDMVSAPGEFSIRGGIIDIYPLTSENPVRIELFDTEVDSIRSFNSDDQRSIETL TSINIGPAKELIIRPEEKARAMEKIDSGLAASLKKLKADKQKEILHANISHDKERLSE GQTDQELVKYLSYFYEKPASLLDYTPDNTLLILDEVSRIHEMEEQLQKEEAEFITNLL EEGKILHDIRLSFSFQKIVAEQKRPLLYYSLFLRHVHHTSPQNIVNVSGRQMQSFHGQ MNVLAGEMERFKKSNFTVVFLGANKERTQKLSSVLADYDIEAAMTDSKKALVQGQVYI MEGELQSGFELPLMKLAVITEEELFKNRVKKKPRKQKLTNAERIKSYSELQIGDYVVH INHGIGKYLGIETLEINGIHKDYLNIHYQGSDKLYVPVEQIDQVQKYVGSEGKEPKLY KLGGSEWKRVKKKVETSVQDIADDLIKLYAEREASKGYAFSPDHEMQREFESAFPYQE TEDQLRSIHEIKKDMERERPMDRLLCGDVGYGKTEVAIRAAFKAIGDGKQVALLVPTT ILAQQHYETIKERFQDYPINIGLLSRFRTRKEANETIKGLKNGTVDIVIGTHRLLSKD VVYKDLGLLIIDEEQRFGVTHKEKIKQIKANVDVLTLTATPIPRTLHMSMLGVRDLSV IETPPENRFPVQTYVVEYNGALVREAIERELARGGQVYFLYNRVEDIERKADEISMLV PDAKVAYAHGKMTENELETVMLSFLEGESDVLVSTTIIETGVDIPNVNTLIVFDADKM GLSQLYQLRGRVGRSNRVAYAYFTYRRDKVLTEVAEKRLQAIKEFTELGSGFKIAMRD LTIRGAGNLLGAQQHGFIDSVGFDLYSQMLKEAIEERKGDTAKTEQFETEIDVELDAY IPETYIQDGKQKIDMYKRFRSVATIEEKNELQDEMIDRFGNYPKEVEYLFTVAEMKVY ARQERVELIKQDKDAVRLTISEEASAEIDGQKLFELGNQYGRQIGLGMEGKKLKISIQ TKGRSADEWLDTVLGMLKGLKDVKKQTISST*" /label="mfd CDS" gene 60021..63554 /gene="mfd" /locus_tag="BSU_00550" /old_locus_tag="BSU00550" /label="mfd gene" promotor_-35 63572..63578 /Source="Nicolas_upshift_promotors" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 63592..63689 /Source="Nicolas_S_feature" /locus_tag="new_64001_64098" /HighExp="S5, S7, S8, S6, S4, Etha, S3, H2O2, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, Sig-, SigB, SigA" /TUshortPSig="1, 0.211, 1, 0.996" /TUlongSig="SigH" /TUlongPSig=1 /label="S35" promotor_-10 63592..63603 /Source="Nicolas_upshift_promotors" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 63592 /Source="Nicolas_upshifts" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" CDS 63690..64226 /gene="spoVT" /locus_tag="BSU_00560" /old_locus_tag="BSU00560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8755877, 15063493, 15939023, 16159768, 18996130, 22522895, 27790204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755877, 15063493, 15939023, 16159768, 18996130, 22522895, 27790204; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of sporulation / germination" /protein_id="NP_387937.1" /db_xref="EnsemblGenomes-Gn:BSU00560" /db_xref="EnsemblGenomes-Tr:CAB11832" /db_xref="GOA:P37554" /db_xref="InterPro:IPR007159" /db_xref="InterPro:IPR014213" /db_xref="PDB:2RO5" /db_xref="PDB:2W1R" /db_xref="PDB:2W1T" /db_xref="SubtiList:BG10119" /db_xref="UniProtKB/Swiss-Prot:P37554" /translation="MKATGIVRRIDDLGRVVIPKEIRRTLRIREGDPLEIFVDRDGEV ILKKYSPISELGDFAKEYADALYDSLGHSVLICDRDVYIAVSGSSKKDYLNKSISEML ERTMDQRSSVLESDAKSVQLVNGIDEDMNSYTVGPIVANGDPIGAVVIFSKDQTMGEV EHKAVETAAGFLARQMEQ*" /label="spoVT CDS" gene 63690..64226 /gene="spoVT" /locus_tag="BSU_00560" /old_locus_tag="BSU00560" /label="spoVT gene" downshifts 64230 /Source="Nicolas_upshifts" /id="D27" /incds=0 /nref=236 /ntot=260 /MaxReadThrough="1.92082" /MaxDrop="6.20706" /score="-2.69593259" /energy="-11.6" /TU="NA" /idTUdmin="U49" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 64326..64345 /Source="Nicolas_upshift_promotors" /id="U53" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=1839 /SigmaFactorBS="gacgctgttctttttcatgcgtgccgaaaaaggaatccaagg gttgggaTGTGGTATAATAACCTCGTTtttatttgtgccgcggtaatacgtgaaccgt a" /listShort="yabM, yabN, yabO, yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 64337 /Source="Nicolas_upshifts" /id="U53" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=1839 /SigmaFactorBS="gacgctgttctttttcatgcgtgccgaaaaaggaatccaagg gttgggaTGTGGTATAATAACCTCGTTtttatttgtgccgcggtaatacgtgaaccgt a" /listShort="yabM, yabN, yabO, yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="upshifts" CDS 64408..66006 /gene="yabM" /locus_tag="BSU_00570" /old_locus_tag="BSU00570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter" /protein_id="NP_387938.1" /db_xref="EnsemblGenomes-Gn:BSU00570" /db_xref="EnsemblGenomes-Tr:CAB11833" /db_xref="GOA:P37555" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG10120" /db_xref="UniProtKB/Swiss-Prot:P37555" /translation="MDDSIGVKRHWIWQGAFVLILAGVITKILSAVYRVPFQNIVGDV GFYIYQQVYPFLGIAVMLSTSGFPVIISKLMNDYSEKNHHTILKISALFLSLIGILLF LCLYLGAVPIALFMGDSHLAVLIQVAAYAFLLFPFVALLRGGFQGRHEMLPSALSQMT EQFLRVAVLLGLSFWLVKKGASLYTAGAAAASGSLAGSLVALIILGFFWFKTKRDNQT DRQNENVITTKELTKKLLLYSVTICVSSLLLLFIQLVDALNLYALLSGGEASEEAKCL KGIYDRGQPLLQLGSVFAVSIATSLVPYISMAVKNKELKIMKEKITSSLKLCLVLGTG ASAGLICILKPVNIMLFQNGEGTGALQVFSCSILFASLAVTAAAVLQGAGYTVFPAIA VGAGVAVKWVLNTLLVPRYGIEGASLATAASFAAVAGLNLYQLRQKEWLDKLRGVLIP IIGSALLMSAVLLAYTRLWTFLFPATGRGAAVIESLSAVAIGGAVFIYCMMRLGIFTD EELNSVPFGSKLSKFMRRREQNGG*" /label="yabM CDS" gene 64408..66006 /gene="yabM" /locus_tag="BSU_00570" /old_locus_tag="BSU00570" /label="yabM gene" promotor_-35 65877..65884 /Source="Nicolas_upshift_promotors" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="promotor_-35" promotor_-10 65899..65918 /Source="Nicolas_upshift_promotors" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="promotor_-10" upshifts 65913 /Source="Nicolas_upshifts" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="upshifts" CDS 65996..67465 /gene="yabN" /locus_tag="BSU_00580" /old_locus_tag="BSU00580" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11178267; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative fusion methylase and nucleotide pyrophosphohydrolase" /protein_id="NP_387939.1" /db_xref="EnsemblGenomes-Gn:BSU00580" /db_xref="EnsemblGenomes-Tr:CAB11834" /db_xref="GOA:P37556" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR011551" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR024180" /db_xref="InterPro:IPR035013" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG10121" /db_xref="UniProtKB/Swiss-Prot:P37556" /translation="MAGKITVVGLGAGDMDQLTIGIHKLLTKADTLYVRTKDHPLIEE LEKETKNIRFFDDIYEKHDQFEAVYEEIADILFEAARREDVVYAVPGHPFVAEKTVQL LTERQEKENVQVKVAGGQSFLDATFNVLQIDPIEGFQFVDAGTLSADELELRHHLIIC QVYDQMTASEVKLTLMEKLPDDYEVVIVTAAGSRGEEIRTVPLFELDRNVALNNLTSV YIPPIKEEKLLYHEFSTFRSIIRELRGPNGCPWDKKQTHQSLKQYMIEECYELLEAID EEDTDHMIEELGDVLLQVLLHAQIGEDEGYFTIDDVIKGISEKMVRRHPHVFKDVKVQ DENDVLANWEDIKKAEKNTSESSLLDSVPKTLPALSKAAKLQKKAAKVGFDWEDVSDI WEKVSEEMKEFSSEVSEAPHEHNLKAEFGDILFALVNVARFYKIEPEEALTMTNDKFR RRFSYIEETAKEEGVELADMSLEDMDKLWNEAKETERRS*" /label="yabN CDS" gene 65996..67465 /gene="yabN" /locus_tag="BSU_00580" /old_locus_tag="BSU00580" /label="yabN gene" promotor_-35 66637..66644 /Source="Nicolas_upshift_promotors" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="promotor_-35" promotor_-10 66658..66676 /Source="Nicolas_upshift_promotors" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="promotor_-10" upshifts 66672 /Source="Nicolas_upshifts" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="upshifts" promotor_no_box complement(67060..67160) /Source="Nicolas_upshift_promotors" /id="U56" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.984015984015984" /psig="0.001998001998002" /xcortree=37 /SigmaFactorBS="cgtcttcccagtcaaaaccgaccttcgctgcttttttctgca atttagctgctttcgaaagagctggaagggttttcggtacgctgtctagtaatgatga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(67100) /Source="Nicolas_upshifts" /id="U56" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.984015984015984" /psig="0.001998001998002" /xcortree=37 /SigmaFactorBS="cgtcttcccagtcaaaaccgaccttcgctgcttttttctgca atttagctgctttcgaaagagctggaagggttttcggtacgctgtctagtaatgatga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 67468..67728 /gene="hslR" /locus_tag="BSU_00590" /old_locus_tag="BSU00590" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10675343, 10675344, 19013177; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal RNA binding protein involved in 50S recycling; heat shock protein" /protein_id="NP_387940.1" /db_xref="EnsemblGenomes-Gn:BSU00590" /db_xref="EnsemblGenomes-Tr:CAB11835" /db_xref="GOA:P37557" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR025490" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10122" /db_xref="UniProtKB/Swiss-Prot:P37557" /translation="MRLDKFLKVSRLIKRRTLAKEVADQGRISINGNQAKASSDVKPG DELTVRFGQKLVTVQVNELKDTTKKEEAANMYTILKEEKLGE*" /label="hslR CDS" gene 67468..67728 /gene="hslR" /locus_tag="BSU_00590" /old_locus_tag="BSU00590" /label="hslR gene" promotor_-35 67733..67738 /Source="Nicolas_upshift_promotors" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 67754..67772 /Source="Nicolas_upshift_promotors" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 67772 /Source="Nicolas_upshifts" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(67804) /Source="Nicolas_upshifts" /id="D28" /incds=0 /nref=3 /ntot=19 /MaxReadThrough="1.93659" /MaxDrop="3.17193" /score="-0.425236437" /energy="-13.9" /TU="NA" /idTUdmin="U62" /TUdmin=3014 /isTUend="FALSE" /label="downshifts" CDS 67807..68109 /gene="spcP" /locus_tag="BSU_00600" /old_locus_tag="BSU00600" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10869437, 11283287, 15231775, 21904870, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869437, 11283287, 15231775, 21904870, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore protein involved in the shaping of the spore coat" /protein_id="NP_387941.1" /db_xref="EnsemblGenomes-Gn:BSU00600" /db_xref="EnsemblGenomes-Tr:CAB11836" /db_xref="GOA:P37558" /db_xref="InterPro:IPR012504" /db_xref="InterPro:IPR022476" /db_xref="SubtiList:BG10123" /db_xref="UniProtKB/Swiss-Prot:P37558" /translation="MNSYYDQKGSSSVPEQHDVTMKGRKHLDISGVKHVESFDNEEFL LETVMGMLSVRGQNLQMKNLDVEKGIVSIKGRVFDLVYLDEQQGDKAKGFFSKLFK*" /label="spcP CDS" gene 67807..68109 /gene="spcP" /locus_tag="BSU_00600" /old_locus_tag="BSU00600" /label="spcP gene" CDS 68106..68741 /gene="spcQ" /locus_tag="BSU_00610" /old_locus_tag="BSU00610" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10869437, 11283287, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869437, 11283287, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="membrane protein of the forespore" /protein_id="NP_387942.1" /db_xref="EnsemblGenomes-Gn:BSU00610" /db_xref="EnsemblGenomes-Tr:CAB11837" /db_xref="GOA:P37559" /db_xref="InterPro:IPR014242" /db_xref="InterPro:IPR019074" /db_xref="SubtiList:BG10124" /db_xref="UniProtKB/Swiss-Prot:P37559" /translation="MTLTTQFYTMLAMSGMGLWLGASLDTYRLFVIRAKTARWLLFIH DILFWIMQGLLFFYVLLHVNEGEFRIYIFLAVLLGVATYQSLCKRIYIKILKFVIYLV VSVYQFFKKLIQHVLFRPIVWTCGAIIWLAAFLFKKTYSLIGFLLLCLYKIVMVLCFP IRFIAKQCLKLLPVKMRLTFRRYFEKGAGFLKKKKKLLITIRTTITRFLKR*" /label="spcQ CDS" gene 68106..68741 /gene="spcQ" /locus_tag="BSU_00610" /old_locus_tag="BSU00610" /label="spcQ gene" promotor_-35 68611..68620 /Source="Nicolas_upshift_promotors" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 68633..68648 /Source="Nicolas_upshift_promotors" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 68635 /Source="Nicolas_upshifts" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 68667..68675 /Source="Nicolas_upshift_promotors" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 68686..68704 /Source="Nicolas_upshift_promotors" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 68696 /Source="Nicolas_upshifts" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="upshifts" CDS 68759..69136 /gene="divIC" /locus_tag="BSU_00620" /old_locus_tag="BSU00620" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:10844672, 11283287, 11994149, 12682299, 16936019, 20870765, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10844672, 11283287, 11994149, 12682299, 16936019, 20870765, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_387943.1" /db_xref="EnsemblGenomes-Gn:BSU00620" /db_xref="EnsemblGenomes-Tr:CAB11838" /db_xref="GOA:P37471" /db_xref="InterPro:IPR007060" /db_xref="SubtiList:BG10125" /db_xref="UniProtKB/Swiss-Prot:P37471" /translation="MNFSRERTITEIQNDYKEQVERQNQLKKRRRKGLYRRLTVFGAL VFLTAIVLASSVWSQTSSLSAKEEKKEQLEKELKSLKTKQTDLKEEISKLKDEDYVTE LARRDLFMSGDGEIIFNVEKKSK*" /label="divIC CDS" gene 68759..69136 /gene="divIC" /locus_tag="BSU_00620" /old_locus_tag="BSU00620" /label="divIC gene" CDS 69217..69603 /gene="yabR" /locus_tag="BSU_00630" /old_locus_tag="BSU00630" /EC_number="2.7.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9862121, 15066026, 16014871, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA degradation protein; polyribonucleotide nucleotidyltransferase or phosphorylase" /protein_id="NP_387944.1" /db_xref="EnsemblGenomes-Gn:BSU00630" /db_xref="EnsemblGenomes-Tr:CAB11839" /db_xref="GOA:P37560" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG10126" /db_xref="UniProtKB/Swiss-Prot:P37560" /translation="MSIEVGSKLQGKITGITNFGAFVELPGGSTGLVHISEVADNYVK DINDHLKVGDQVEVKVINVEKDGKIGLSIKKAKDRPQARPRNDFRPKESFEQKMNKFL KDSEDRLSSLKRNTESKRGGRGARRG*" /label="yabR CDS" gene 69217..69603 /gene="yabR" /locus_tag="BSU_00630" /old_locus_tag="BSU00630" /label="yabR gene" downshifts 69597 /Source="Nicolas_upshifts" /id="D29" /incds=0 /nref=247 /ntot=274 /MaxReadThrough="3.67278" /MaxDrop="8.3221" /score="23.2738869" /energy="-12.5" /TU="U58" /idTUdmin="U53" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 69711..69718 /Source="Nicolas_upshift_promotors" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 69732..69751 /Source="Nicolas_upshift_promotors" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 69747 /Source="Nicolas_upshifts" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="upshifts" tRNA 69772..69848 /gene="trnSL-Met1" /locus_tag="BSU_tRNA_10" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="methionine transfer RNA (CAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Met1 tRNA" gene 69772..69848 /gene="trnSL-Met1" /locus_tag="BSU_tRNA_10" /label="trnSL-Met1 gene" tRNA 69858..69929 /gene="trnSL-Glu1" /locus_tag="BSU_tRNA_11" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="glutamate transfer RNA (UUC); Evidence 2a: Functionfrom experimental evidences in other organisms; Producttype n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Glu1 tRNA" gene 69858..69929 /gene="trnSL-Glu1" /locus_tag="BSU_tRNA_11" /label="trnSL-Glu1 gene" downshifts 69928 /Source="Nicolas_upshifts" /id="D30" /incds=0 /nref=2 /ntot=58 /MaxReadThrough="4.83761" /MaxDrop="5.55326" /score="25.2769629" /energy="-10.8" /TU="U58,U60" /idTUdmin="U58" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" S_feature 69973..70084 /Source="Nicolas_S_feature" /locus_tag="new_70382_70493" /HighExp="Cold, G180, C30, G135, G150, Oxctl, Paraq, H2O2, Heat, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S36" misc_feature 70080..70099 /Source="Nicolas_upshift_promotors" /id="U61" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.99000999000999" /xcortree=442 /SigmaFactorBS="cgtcgaagatttctttggtattgttaccttcttttgacaaaa tcctatctgtgcTTTCGCTATAATGACAGGCAacgaatataacaggtgggagatgaga g" /listShort="spoIIE, yabS, yabT, tilS" /listLong="hprT, S38, ftsH" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 70086 /Source="Nicolas_upshifts" /id="U61" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.99000999000999" /xcortree=442 /SigmaFactorBS="cgtcgaagatttctttggtattgttaccttcttttgacaaaa tcctatctgtgcTTTCGCTATAATGACAGGCAacgaatataacaggtgggagatgaga g" /listShort="spoIIE, yabS, yabT, tilS" /listLong="hprT, S38, ftsH" /label="upshifts" CDS 70129..72612 /gene="spoIIE" /locus_tag="BSU_00640" /old_locus_tag="BSU00640" /EC_number="3.1.3.16" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10747015, 12180929, 15126482, 15866939, 15978076, 28358838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10747015, 12180929, 15126482, 15866939, 15978076, 28358838; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="SpoIIAA-phosphate serine phosphatase" /protein_id="NP_387945.1" /db_xref="EnsemblGenomes-Gn:BSU00640" /db_xref="EnsemblGenomes-Tr:CAB11840" /db_xref="GOA:P37475" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR014221" /db_xref="InterPro:IPR036457" /db_xref="PDB:3T91" /db_xref="PDB:3T9Q" /db_xref="PDB:5UCG" /db_xref="SubtiList:BG10127" /db_xref="UniProtKB/Swiss-Prot:P37475" /translation="MEKAERRVNGPMAGQALEKLQSFFNRGTKLVTHHLHSLFFYKGF IYVVIGFLLGRAFILSEVLPFALPFFGAMLLIRRDKAFYAVLAVLAGALTISPKHSLL ILAALLAFFVFSKVAAFITDDRVKALPIVVFFSMAAARAGFVYAQNGVFTTYDYVMAI VEAGLSFILTLIFLQSLPIFTVKKVKQSLKIEEIICFMILIASVLTGLAGLSYQGMQA EHILARYVVLSFSFIGGASIGCTVGVVTGLILGLANIGNLYQMSLLAFSGLLGGLLKE GKKAGAAIGLIVGSLLISLYGEGSAGLMTTLYESLIAVCLFLLTPQSITRKVARYIPG TVEHLQEQQQYARKIRDVTAQKVDQFSNVFHALSESFATFYQASDEQTDDSEVDLFLS KITEHSCQTCYKKNRCWVQNFDKTYDLMKQVMLETEEKEYASNRRLKKEFQQYCSKSK QVEELIEDELAHHHAHLTLKKKVQDSRRLVAEQLLGVSEVMADFSREIKREREQHFLQ EEQIIEALQHFGIEIQHVEIYSLEQGNIDIEMTIPFSGHGESEKIIAPMLSDILEEQI LVKAEQHSPHPNGYSHVAFGSTKSYRVSTGAAHAAKGGGLVSGDSYSMMELGARKYAA AISDGMGNGARAHFESNETIKLLEKILESGIDEKIAIKTINSILSLRTTDEIYSTLDL SIIDLQDASCKFLKVGSTPSFIKRGDQVMKVQASNLPIGIINEFDVEVVSEQLKAGDL LIMMSDGIFEGPKHVENHDLWMKRKMKGLKTNDPQEIADLLMEEVIRTRSGQIEDDMT VVVVRIDHNTPKWASIPVPAIFQNKQEIS*" /label="spoIIE CDS" gene 70129..72612 /gene="spoIIE" /locus_tag="BSU_00640" /old_locus_tag="BSU00640" /label="spoIIE gene" downshifts 70170 /Source="Nicolas_upshifts" /id="D31" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="5.5737" /MaxDrop="3.93473" /score="25.2769629" /energy="-10.8" /TU="U60,U61" /idTUdmin="U58" /TUdmin=44 /isTUend="FALSE" /label="downshifts" S_feature complement(70781..71390) /Source="Nicolas_S_feature" /locus_tag="new_71190_71799_c" /HighExp="S8, S6, S4, S5, S3, S7, M9-stat, T5.0H, LoTm, Pyr" /AntisenseName="spoIIE" /AntisenseCor="0.685558251745638" /AntisenseRegPval="-38" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S37" downshifts complement(70807) /Source="Nicolas_upshifts" /id="D32" /incds=1 /nref=2 /ntot=11 /MaxReadThrough="2.2425" /MaxDrop="4.29972" /score="-0.425236437" /energy="-13.9" /TU="NA" /idTUdmin="U62" /TUdmin=11 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(71363..71381) /Source="Nicolas_upshift_promotors" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(71389) /Source="Nicolas_upshifts" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(71397..71402) /Source="Nicolas_upshift_promotors" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 71594..71600 /Source="Nicolas_upshift_promotors" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 71615..71633 /Source="Nicolas_upshift_promotors" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 71622 /Source="Nicolas_upshifts" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 72632..72635 /Source="Nicolas_upshift_promotors" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 72653..72670 /Source="Nicolas_upshift_promotors" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 72656 /Source="Nicolas_upshifts" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="upshifts" CDS 72697..73434 /gene="yabS" /locus_tag="BSU_00650" /old_locus_tag="BSU00650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387946.1" /db_xref="EnsemblGenomes-Gn:BSU00650" /db_xref="EnsemblGenomes-Tr:CAB11841" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG10128" /db_xref="UniProtKB/Swiss-Prot:P37561" /translation="MNNGHLNQILLITDGCSNHGEDPLAMAAFAKEQGITVNVIGIME ENQIDPEAMKEVEGIALAGGGVHQVVYASQLSQTVQMVTKKAMTQTLQGVVNQELKQI LGKNVEMEELSPEKRGEVMEVVDELGETVHLQVLVLVDTSASMAPKLPTVKEALIDLS VSLNSRIGNNEFAMCIFPGKKQEVELVLNWTPKLQSLSTLFAKLSTGGITPTGPAIRE ATLQFEKIRSRRGMLADDERRFDEFGM*" /label="yabS CDS" gene 72697..73434 /gene="yabS" /locus_tag="BSU_00650" /old_locus_tag="BSU00650" /label="yabS gene" CDS 73400..74416 /gene="prkT" /locus_tag="BSU_00660" /old_locus_tag="BSU00660" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23634894, 24731262, 25278935" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23634894, 24731262, 25278935; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine/threonine-protein kinase" /protein_id="NP_387947.2" /db_xref="EnsemblGenomes-Gn:BSU00660" /db_xref="EnsemblGenomes-Tr:CAB11842" /db_xref="GOA:P37562" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG10129" /db_xref="UniProtKB/Swiss-Prot:P37562" /translation="MMNDALTSLACSLKPGTTIKGKWNGNTYTLRKQLGKGANGIVYL AETSDGHVALKVSDDSLSITSEVNVLKSFSKAQSVTMGPSFFDTDDAYIPSANTKVSF YAMEYIKGPLLLKYVSDKGAEWIPVLMIQLLSSLSVLHQQGWIFGDLKPDNLIVTGPP ARIRCIDVGGTTKEGRAIKEYTEFYDRGYWGYGTRKAEPSYDLFAVAMIMINSVHKKE FKKTNQPKEQLRSLIEGNPLLQKYKKALFSALNGDYQSADEMKKDMLDAGQKAAQRKQ PIKASPQPATRQRQQKPRQGKITKTRYTPKQKPAKSGGLFETTLIVISVLALYFAYII FFLI*" /label="prkT CDS" gene 73400..74416 /gene="prkT" /locus_tag="BSU_00660" /old_locus_tag="BSU00660" /label="prkT gene" promotor_-35 73948..73954 /Source="Nicolas_upshift_promotors" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="promotor_-35" promotor_-10 73970..73988 /Source="Nicolas_upshift_promotors" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="promotor_-10" upshifts 73976 /Source="Nicolas_upshifts" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="upshifts" promotor_-35 74446..74453 /Source="Nicolas_upshift_promotors" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 74467..74486 /Source="Nicolas_upshift_promotors" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 74477 /Source="Nicolas_upshifts" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" CDS 74520..75938 /gene="tilS" /locus_tag="BSU_00670" /old_locus_tag="BSU00670" /EC_number="6.3.4.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14527414, 16039592, 17005971, 22720735, 24001521" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14527414, 16039592, 17005971, 22720735, 24001521; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(ile2) lysidine synthetase" /protein_id="NP_387948.1" /db_xref="EnsemblGenomes-Gn:BSU00670" /db_xref="EnsemblGenomes-Tr:CAB11843" /db_xref="GOA:P37563" /db_xref="InterPro:IPR011063" /db_xref="InterPro:IPR012094" /db_xref="InterPro:IPR012795" /db_xref="InterPro:IPR012796" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015262" /db_xref="InterPro:IPR020825" /db_xref="SubtiList:BG10130" /db_xref="UniProtKB/Swiss-Prot:P37563" /translation="MKSVKDFLNKHNLTLKGATIIVGVSGGPDSMALLHALHTLCGRS ANVIAAHVDHRFRGAESEEDMRFVQAYCKAEQLVCETAQINVTAYAQEKGLNKQAAAR DCRYQFFEEIMSKHQADYLALAHHGDDQVETMLMKLAKGTLGTGLAGMQPVRRFGTGR IIRPFLTITKEEILHYCHENGLSYRTDESNAKDDYTRNRFRKTVLPFLKQESPDVHKR FQKVSEALTEDEQFLQSLTKDEMNKVITSQSNTSVEINSSQLLALPMPLQRRGVQLIL NYLYENVPSSFSAHHIQQFLDWAENGGPSGVLDFPKGLKVVKSYQTCLFTFEQWQCKN VPFEYQISGAADETAVLPNGYLIEARHYADSPEEHGNAVFITSEKKVRFPLTIRTRKA GDRIKLKGMNGSKKVKDIFIDKKLPLQERDNWPIVTDASGEIIWIPGLKKSIFEDLVI PNSDRIVLQYRQHEKCRGQAKS*" /label="tilS CDS" gene 74520..75938 /gene="tilS" /locus_tag="BSU_00670" /old_locus_tag="BSU00670" /label="tilS gene" promotor_-35 75315..75322 /Source="Nicolas_upshift_promotors" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 75337..75356 /Source="Nicolas_upshift_promotors" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 75340 /Source="Nicolas_upshifts" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" downshifts complement(75933) /Source="Nicolas_upshifts" /id="D33" /incds=0 /nref=2 /ntot=142 /MaxReadThrough="2.51342" /MaxDrop="2.96272" /score="12.3455896" /energy="-9.1" /TU="NA" /idTUdmin="U68" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS 75935..76477 /gene="hprT" /locus_tag="BSU_00680" /old_locus_tag="BSU00680" /EC_number="2.4.2.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3110131, 6408059, 24001521" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3110131, 6408059, 24001521; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hypoxanthine-guanine phosphoribosyltransferase" /protein_id="NP_387949.1" /db_xref="EnsemblGenomes-Gn:BSU00680" /db_xref="EnsemblGenomes-Tr:CAB11844" /db_xref="GOA:P37472" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005904" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10131" /db_xref="UniProtKB/Swiss-Prot:P37472" /translation="MMKHDIEKVLISEEEIQKKVKELGAELTSEYQDTFPLAIGVLKG ALPFMADLIKHIDTYLEMDFMDVSSYGNSTVSSGEVKIIKDLDTSVEGRDILIIEDII DSGLTLSYLVELFRYRKAKSIKIVTLLDKPSGRKADIKADFVGFEVPDAFVVGYGLDY AERYRNLPYIGVLKPAVYES*" /label="hprT CDS" gene 75935..76477 /gene="hprT" /locus_tag="BSU_00680" /old_locus_tag="BSU00680" /label="hprT gene" upshifts complement(76340) /Source="Nicolas_upshifts" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(76342..76346) /Source="Nicolas_upshift_promotors" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(76364..76367) /Source="Nicolas_upshift_promotors" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 76478..76574 /Source="Nicolas_S_feature" /locus_tag="new_76887_76983" /HighExp="Diami, H2O2, dia5, G135, dia15, G150, Paraq, C90, G180, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.999, 1, 0.842" /TUlongSig="SigB, SigA" /TUlongPSig="1, 0.99" /label="S38" CDS 76575..78488 /gene="ftsH" /locus_tag="BSU_00690" /old_locus_tag="BSU00690" /EC_number="3.4.24.-" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9076729, 9084181, 9287010, 9352926, 10851010, 10913836, 12533473, 24001521, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9076729, 9084181, 9287010, 9352926, 10851010, 10913836, 12533473, 24001521, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent cytoplasmic membrane protease" /protein_id="NP_387950.1" /db_xref="EnsemblGenomes-Gn:BSU00690" /db_xref="EnsemblGenomes-Tr:CAB11845" /db_xref="GOA:P37476" /db_xref="InterPro:IPR000642" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR003960" /db_xref="InterPro:IPR005936" /db_xref="InterPro:IPR011546" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR037219" /db_xref="SubtiList:BG10132" /db_xref="UniProtKB/Swiss-Prot:P37476" /translation="MNRVFRNTIFYLLILLVVIGVVSYFQTSNPKTENMSYSTFIKNL DDGKVDSVSVQPVRGVYEVKGQLKNYDKDQYFLTHVPEGKGADQIFNALKKTDVKVEP AQETSGWVTFLTTIIPFVIIFILFFFLLNQAQGGGSRVMNFGKSKAKLYTEEKKRVKF KDVAGADEEKQELVEVVEFLKDPRKFAELGARIPKGVLLVGPPGTGKTLLAKACAGEA GVPFFSISGSDFVEMFVGVGASRVRDLFENAKKNAPCLIFIDEIDAVGRQRGAGLGGG HDEREQTLNQLLVEMDGFSANEGIIIIAATNRADILDPALLRPGRFDRQITVDRPDVI GREAVLKVHARNKPLDETVNLKSIAMRTPGFSGADLENLLNEAALVAARQNKKKIDAR DIDEATDRVIAGPAKKSRVISKKERNIVAYHEGGHTVIGLVLDEADMVHKVTIVPRGQ AGGYAVMLPREDRYFQTKPELLDKIVGLLGGRVAEEIIFGEVSTGAHNDFQRATNIAR RMVTEFGMSEKLGPLQFGQSQGGQVFLGRDFNNEQNYSDQIAYEIDQEIQRIIKECYE RAKQILTENRDKLELIAQTLLKVETLDAEQIKHLIDHGTLPERNFSDDEKNDDVKVNI LTKTEEKKDDTKE*" /label="ftsH CDS" gene 76575..78488 /gene="ftsH" /locus_tag="BSU_00690" /old_locus_tag="BSU00690" /label="ftsH gene" downshifts 78486 /Source="Nicolas_upshifts" /id="D34" /incds=0 /nref=187 /ntot=269 /MaxReadThrough="5.00908" /MaxDrop="8.91482" /score="38.4132386" /energy="-12.9" /TU="U66,U67" /idTUdmin="U64" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(78525..78529) /Source="Nicolas_upshift_promotors" /id="U69" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.955044955044955" /psig="0.000999000999001" /xcortree=66 /SigmaFactorBS="aaatcgataccagaattggatgattgtaaaagccgcagctga gccaatcatttacataaaaaaaCTGCCagcgtcagccggcagtttttttagaaagaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 78531..78616 /Source="Nicolas_S_feature" /locus_tag="new_78940_79025" /HighExp="H2O2, G180, G135, dia15, Paraq, G150, Oxctl, Diami, Cold, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S39" upshifts complement(78533) /Source="Nicolas_upshifts" /id="U69" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.955044955044955" /psig="0.000999000999001" /xcortree=66 /SigmaFactorBS="aaatcgataccagaattggatgattgtaaaagccgcagctga gccaatcatttacataaaaaaaCTGCCagcgtcagccggcagtttttttagaaagaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 78593..78600 /Source="Nicolas_upshift_promotors" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 78614..78633 /Source="Nicolas_upshift_promotors" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" S_feature 78618..78682 /Source="Nicolas_S_feature" /locus_tag="new_79027_79091" /HighExp="dia5, H2O2, dia15, Paraq, Diami, G180, LBGexp, Oxctl, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S40" upshifts 78618 /Source="Nicolas_upshifts" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" CDS 78683..79459 /gene="coaX" /locus_tag="BSU_00700" /old_locus_tag="BSU00700" /EC_number="2.7.1.33" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15795230, 16905099, 24784177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15795230, 16905099, 24784177; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate kinase type III" /protein_id="NP_387951.2" /db_xref="EnsemblGenomes-Gn:BSU00700" /db_xref="EnsemblGenomes-Tr:CAB11846" /db_xref="GOA:P37564" /db_xref="InterPro:IPR004619" /db_xref="SubtiList:BG10133" /db_xref="UniProtKB/Swiss-Prot:P37564" /translation="MLLVIDVGNTNTVLGVYHDGKLEYHWRIETSRHKTEDEFGMILR SLFDHSGLMFEQIDGIIISSVVPPIMFALERMCTKYFHIEPQIVGPGMKTGLNIKYDN PKEVGADRIVNAVAAIHLYGNPLIVVDFGTATTYCYIDENKQYMGGAIAPGITISTEA LYSRAAKLPRIEITRPDNIIGKNTVSAMQSGILFGYVGQVEGIVKRMKWQAKQEPKVI ATGGLAPLIANESDCIDIVDPFLTLKGLELIYERNRVGSV*" /label="coaX CDS" gene 78683..79459 /gene="coaX" /locus_tag="BSU_00700" /old_locus_tag="BSU00700" /label="coaX gene" CDS 79471..80346 /gene="hslO" /locus_tag="BSU_00710" /old_locus_tag="BSU00710" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11323724, 15023991; Product type f: factor" /codon_start=1 /transl_table=11 /product="disulfide bond chaperone (heat shock protein HSP33)" /protein_id="NP_387952.1" /db_xref="EnsemblGenomes-Gn:BSU00710" /db_xref="EnsemblGenomes-Tr:CAB11847" /db_xref="GOA:P37565" /db_xref="InterPro:IPR000397" /db_xref="InterPro:IPR016153" /db_xref="InterPro:IPR016154" /db_xref="PDB:1VZY" /db_xref="SubtiList:BG10134" /db_xref="UniProtKB/Swiss-Prot:P37565" /translation="MDYLVKALAYDGKVRAYAARTTDMVNEGQRRHGTWPTASAALGR TMTASLMLGAMLKGDDKLTVKIEGGGPIGAIVADANAKGEVRAYVSNPQVHFDLNEQG KLDVRRAVGTNGTLSVVKDLGLREFFTGQVEIVSGELGDDFTYYLVSSEQVPSSVGVG VLVNPDNTILAAGGFIIQLMPGTDDETITKIEQRLSQVEPISKLIQKGLTPEEILEEV LGEKPEILETMPVRFHCPCSKERFETAILGLGKKEIQDMIEEDGQAEAVCHFCNEKYL FTKEELEGLRDQTTR*" /label="hslO CDS" gene 79471..80346 /gene="hslO" /locus_tag="BSU_00710" /old_locus_tag="BSU00710" /label="hslO gene" CDS 80393..81286 /gene="yacD" /locus_tag="BSU_00720" /old_locus_tag="BSU00720" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182, 15856219; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative protein chaperone accessory lipoproteinfactor" /protein_id="NP_387953.1" /db_xref="EnsemblGenomes-Gn:BSU00720" /db_xref="EnsemblGenomes-Tr:CAB11848" /db_xref="GOA:P37566" /db_xref="InterPro:IPR000297" /db_xref="InterPro:IPR023058" /db_xref="InterPro:IPR027304" /db_xref="SubtiList:BG10135" /db_xref="UniProtKB/Swiss-Prot:P37566" /translation="MKSRTIWTIILGALLVCCIAVAYTLTKSQAGASSSGESIATIGG KSVTREEWLKEMEDQYGKSTLEDMINVRVVEQLAKKNKLKISKSEVDREFLLIKAVNN SFYEDEHTTEKEWKDQIRYNILLEDLLTRDIDISNKELESFYNKNKELYQFDDSYRIR HIVVKDEEEAREVLKELKGGSSFEAVAAERSTDRYTSPYGGDLGFVTEASDNIPSAYI EEAKTLKEDEWSQEPIKVSNGYAIIQLKEKLKARTFSFDEVKDQIRRQIAMDQLGDKA TVKTLWKEADVSWFYGEKSTK*" /label="yacD CDS" gene 80393..81286 /gene="yacD" /locus_tag="BSU_00720" /old_locus_tag="BSU00720" /label="yacD gene" promotor_-35 81016..81021 /Source="Nicolas_upshift_promotors" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 81038..81056 /Source="Nicolas_upshift_promotors" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 81039 /Source="Nicolas_upshifts" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="upshifts" promotor_-35 81285..81292 /Source="Nicolas_upshift_promotors" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 81307..81326 /Source="Nicolas_upshift_promotors" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 81314 /Source="Nicolas_upshifts" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" CDS 81362..82288 /gene="cysK" /locus_tag="BSU_00730" /old_locus_tag="BSU00730" /EC_number="2.5.1.47" /EC_number="4.4.1.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 15760717, 16267287, 16513748, 17056751, 18974048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 15760717, 16267287, 16513748, 17056751, 18974048; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cysteine synthase" /protein_id="NP_387954.1" /db_xref="EnsemblGenomes-Gn:BSU00730" /db_xref="EnsemblGenomes-Tr:CAB11849" /db_xref="GOA:P37887" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR005856" /db_xref="InterPro:IPR005859" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10136" /db_xref="UniProtKB/Swiss-Prot:P37887" /translation="MVRVANSITELIGNTPIVKLNRLADENSADVYLKLEYMNPGSSV KDRIGLAMIEAAEKEGKLKAGNTIIEPTSGNTGIGLAMVAAAKGLKAILVMPDTMSME RRNLLRAYGAELVLTPGAEGMKGAIKKAEELAEKHGYFVPQQFNNPSNPEIHRQTTGK EIVEQFGDDQLDAFVAGIGTGGTITGAGEVLKEAYPSIKIYAVEPSDSPVLSGGKPGP HKIQGIGAGFVPDILNTEVYDEIFPVKNEEAFEYARRAAREEGILGGISSGAAIYAAL QVAKKLGKGKKVLAIIPSNGERYLSTPLYQFD*" /label="cysK CDS" gene 81362..82288 /gene="cysK" /locus_tag="BSU_00730" /old_locus_tag="BSU00730" /label="cysK gene" downshifts 82281 /Source="Nicolas_upshifts" /id="D35" /incds=0 /nref=156 /ntot=259 /MaxReadThrough="5.90023" /MaxDrop="5.38596" /score="41.7897705" /energy="-11.4" /TU="U72" /idTUdmin="U70" /TUdmin=10 /isTUend="TRUE" /label="downshifts" promotor_-35 82335..82343 /Source="Nicolas_upshift_promotors" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 82357..82365 /Source="Nicolas_upshift_promotors" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 82359 /Source="Nicolas_upshifts" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="upshifts" promotor_-35 82387..82390 /Source="Nicolas_upshift_promotors" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-35" promotor_-10 82405..82424 /Source="Nicolas_upshift_promotors" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-10" upshifts 82415 /Source="Nicolas_upshifts" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="upshifts" CDS 82455..83867 /gene="pabB" /locus_tag="BSU_00740" /old_locus_tag="BSU00740" /EC_number="2.6.1.85" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2123867, 9084182, 16605270, 17114263, 25288929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate synthase (para-aminobenzoate synthase)" /protein_id="NP_387955.1" /db_xref="EnsemblGenomes-Gn:BSU00740" /db_xref="EnsemblGenomes-Tr:CAB11850" /db_xref="GOA:P28820" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR006805" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR019999" /db_xref="SubtiList:BG10137" /db_xref="UniProtKB/Swiss-Prot:P28820" /translation="MAQRRPAGKKIPFQKDSFLQQFEKLAQSRKHHVLLESARGGRYS IAGLDPIATVKGKDGITTIKHGDEMLFKEGDPLRAFHSWFKTLETETNHEFPDFQGGA IGFLSYDYARYIENFKMLSLDDLETPDIYFLVFDDIAVYDHQEESLWLITHVNGSDQE TADVKLSELEQMWLTELPAVTSREMKPETAGSFAAPFTEDGFSQAVEKIKQYIASGDV FQVNLSIRQSQSLSVHPYQIYKTLREVNPSPYMAYLETPDFQIICGSPELLVSKKGKL LETRPIAGTRSRGKTNEEDEALANELIHNEKERAEHVMLVDLERNDLGRVSRYGSVRV NEFMAIEKYSHVMHIVSNVQGELQDGYDAVDIIHAVFPGGTITGAPKVRTMEIIEELE PTRRGLYTGSIGWFGYNHDLQFNIVIRTIYATGGQAFMQSGAGVVIDSVPKHEYKESF KKAFAMQRALELSEEETKIR*" /label="pabB CDS" gene 82455..83867 /gene="pabB" /locus_tag="BSU_00740" /old_locus_tag="BSU00740" /label="pabB gene" promotor_-35 83257..83259 /Source="Nicolas_upshift_promotors" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 83277..83295 /Source="Nicolas_upshift_promotors" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 83283 /Source="Nicolas_upshifts" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="upshifts" promotor_-35 83624..83631 /Source="Nicolas_upshift_promotors" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-35" promotor_-10 83644..83663 /Source="Nicolas_upshift_promotors" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-10" upshifts 83657 /Source="Nicolas_upshifts" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="upshifts" CDS 83881..84465 /gene="pabA" /locus_tag="BSU_00750" /old_locus_tag="BSU00750" /EC_number="2.6.1.85" /EC_number="4.1.3.27" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098056, 16605270, 17114263, 24847778; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate synthase; anthranilatesynthase (subunit II)" /protein_id="NP_387956.1" /db_xref="EnsemblGenomes-Gn:BSU00750" /db_xref="EnsemblGenomes-Tr:CAB11851" /db_xref="GOA:P28819" /db_xref="InterPro:IPR006221" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10138" /db_xref="UniProtKB/Swiss-Prot:P28819" /translation="MILMIDNYDSFTYNLVQYLGELGEELVVKRNDSITIDEIEELSP DFLMISPGPCSPDEAGISLEAIKHFAGKIPIFGVCLGHQSIAQVFGGDVVRAERLMHG KTSDIEHDGKTIFEGLKNPLVATRYHSLIVKPETLPSCFTVTAQTKEGEIMAIRHNDL PIEGVQFHPESIMTSFGKEMLRNFIETYRKEVIA*" /label="pabA CDS" gene 83881..84465 /gene="pabA" /locus_tag="BSU_00750" /old_locus_tag="BSU00750" /label="pabA gene" CDS 84465..85346 /gene="pabC" /locus_tag="BSU_00760" /old_locus_tag="BSU00760" /EC_number="4.1.3.38" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10876155, 1644759, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate pyruvate-lyase" /protein_id="NP_387957.1" /db_xref="EnsemblGenomes-Gn:BSU00760" /db_xref="EnsemblGenomes-Tr:CAB11852" /db_xref="GOA:P28821" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR017824" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG10139" /db_xref="UniProtKB/Swiss-Prot:P28821" /translation="MIYVNGRYMEEKDAVLSPFDHGFLYGIGVFETFRLYEGCPFLLD WHIERLERALKDLQIEYTVSKHEILEMLDKLLKLNDIKDGNARVRLNISAGISDKGFV AQTYDKPTVLCFVNQLKPESLPLQKEGKVLSIRRNTPEGSFRLKSHHYLNNMYAKREI GNDPRVEGIFLTEDGAVAEGIISNVFWRKGRCIYTPSLDTGILDGVTRRFIIENAKDI GLELKTGRYELEALLTADEAWMTNSVLEIIPFTKIEEVNYGSQSGEATSALQLLYKKE IKNMIHEKGGRAWRSTQ*" /label="pabC CDS" gene 84465..85346 /gene="pabC" /locus_tag="BSU_00760" /old_locus_tag="BSU00760" /label="pabC gene" CDS 85328..86185 /gene="folP" /locus_tag="BSU_00770" /old_locus_tag="BSU00770" /EC_number="2.5.1.15" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2123867, 11007651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydropteroate synthase" /protein_id="NP_387958.1" /db_xref="EnsemblGenomes-Gn:BSU00770" /db_xref="EnsemblGenomes-Tr:CAB11853" /db_xref="GOA:P28822" /db_xref="InterPro:IPR000489" /db_xref="InterPro:IPR006390" /db_xref="InterPro:IPR011005" /db_xref="SubtiList:BG10140" /db_xref="UniProtKB/Swiss-Prot:P28822" /translation="MAQHTIDQTQVIHTKPSALSYKEKTLVMGILNVTPDSFSDGGKY DSLDKALLHAKEMIDDGAHIIDIGGESTRPGAECVSEDEEMSRVIPVIERITKELGVP ISVDTYKASVADEAVKAGASIINDIWGAKHDPKMASVAAEHNVPIVLMHNRPERNYND LLPDMLSDLMESVKIAVEAGVDEKNIILDPGIGFAKTYHDNLAVMNKLEIFSGLGYPV LLATSRKRFIGRVLDLPPEERAEGTGATVCLGIQKGCDIVRVHDVKQIARMAKMMDAM LNKGGVHHG*" /label="folP CDS" gene 85328..86185 /gene="folP" /locus_tag="BSU_00770" /old_locus_tag="BSU00770" /label="folP gene" CDS 86178..86540 /gene="folB" /locus_tag="BSU_00780" /old_locus_tag="BSU00780" /EC_number="4.1.2.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16188473, 17176045, 17388809; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroneopterin aldolase" /protein_id="NP_387959.1" /db_xref="EnsemblGenomes-Gn:BSU00780" /db_xref="EnsemblGenomes-Tr:CAB11854" /db_xref="GOA:P28823" /db_xref="InterPro:IPR006156" /db_xref="InterPro:IPR006157" /db_xref="SubtiList:BG10141" /db_xref="UniProtKB/Swiss-Prot:P28823" /translation="MDKVYVEGMEFYGYHGVFTEENKLGQRFKVDLTAELDLSKAGQT DDLEQTINYAELYHVCKDIVEGEPVKLVETLAERIAGTVLGKFQPVQQCTVKVIKPDP PIPGHYKSVAIEITRKKS*" /label="folB CDS" gene 86178..86540 /gene="folB" /locus_tag="BSU_00780" /old_locus_tag="BSU00780" /label="folB gene" CDS 86537..87040 /gene="folK" /locus_tag="BSU_00790" /old_locus_tag="BSU00790" /EC_number="2.7.6.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17029412; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase" /protein_id="NP_387960.1" /db_xref="EnsemblGenomes-Gn:BSU00790" /db_xref="EnsemblGenomes-Tr:CAB11855" /db_xref="GOA:P29252" /db_xref="InterPro:IPR000550" /db_xref="InterPro:IPR035907" /db_xref="SubtiList:BG10142" /db_xref="UniProtKB/Swiss-Prot:P29252" /translation="MNNIAYIALGSNIGDRETYLRQAVALLHQHAAVTVTKVSSIYET DPVGYEDQAQFLNMAVEIKTSLNPFELLELTQQIENELGRTREVRWGPRTADLDILLF NRENIETEQLIVPHPRMYERLFVLAPLAEICQQVEKEATSAETDQEGVRVWKQKSGVD EFVHSES*" /label="folK CDS" gene 86537..87040 /gene="folK" /locus_tag="BSU_00790" /old_locus_tag="BSU00790" /label="folK gene" CDS 86992..87201 /gene="yazB" /locus_tag="BSU_00800" /old_locus_tag="BSU00800" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_387961.1" /db_xref="EnsemblGenomes-Gn:BSU00800" /db_xref="EnsemblGenomes-Tr:CAB11856" /db_xref="GOA:O31417" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG12701" /db_xref="UniProtKB/Swiss-Prot:O31417" /translation="MEAEIWGRRIRAFRKLKGYTQEGFAKALGISVSILGEIERGNRL PSAAIIQDAADVLNISADELAPPEK*" /label="yazB CDS" gene 86992..87201 /gene="yazB" /locus_tag="BSU_00800" /old_locus_tag="BSU00800" /label="yazB gene" CDS 87225..88226 /gene="dusB" /locus_tag="BSU_00810" /old_locus_tag="BSU00810" /EC_number="1.-.-.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11983710, 15698474, 26112661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-dihydrouridine synthase B" /protein_id="NP_387962.1" /db_xref="EnsemblGenomes-Gn:BSU00810" /db_xref="EnsemblGenomes-Tr:CAB11857" /db_xref="GOA:P37567" /db_xref="InterPro:IPR001269" /db_xref="InterPro:IPR004652" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018517" /db_xref="InterPro:IPR024036" /db_xref="InterPro:IPR035587" /db_xref="SubtiList:BG10143" /db_xref="UniProtKB/Swiss-Prot:P37567" /translation="MFKIGDIQLKNRVVLAPMAGVCNSAFRLTVKEFGAGLVCAEMVS DKAILYNNARTMGMLYIDEREKPLSLQIFGGKKETLVEAAKFVDQNTTADIIDINMGC PVPKITKCDAGAKWLLDPDKIYEMVSAVVDAVNKPVTVKMRMGWDEDHIFAVKNAQAV ERAGGKAVALHGRTRVQMYEGTANWDIIKEVKQSVSIPVIGNGDVKTPQDAKRMLDET GVDGVMIGRAALGNPWMIYRTVQYLETGKLKEEPQVREKMAVCKLHLDRLIDLKGENV AVREMRKHAAWYLKGVKGNANVRNEINHCETREEFVQLLDAFTVEVEAKELQNAKVG* " /label="dusB CDS" gene 87225..88226 /gene="dusB" /locus_tag="BSU_00810" /old_locus_tag="BSU00810" /label="dusB gene" S_feature complement(87641..89157) /Source="Nicolas_S_feature" /locus_tag="new_88050_89566_c" /HighExp="LoTm, C30, S6, S8, S5, S7, S3, S4, C90, G135" /AntisenseName="dusB" /AntisenseCor="-0.60218706634778196" /AntisenseRegPval="-27.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S41" S_feature 88227..88317 /Source="Nicolas_S_feature" /locus_tag="new_88636_88726" /HighExp="H2O2, G180, G150, Paraq, G135, Oxctl, Diami, C30, LBGexp, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.998" /TUlongSig="SigA, SigI, SigA, SigEF, SigA, SigA, SigA" /TUlongPSig="0.621, 0.787, 1, 0.995, 1, 0.999, 1" /label="S42" CDS 88318..89817 /gene="lysS" /locus_tag="BSU_00820" /old_locus_tag="BSU00820" /EC_number="6.1.1.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14623972, 20649968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14623972, 20649968; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lysyl-tRNA synthetase" /protein_id="NP_387963.1" /db_xref="EnsemblGenomes-Gn:BSU00820" /db_xref="EnsemblGenomes-Tr:CAB11858" /db_xref="GOA:P37477" /db_xref="InterPro:IPR002313" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR018149" /db_xref="InterPro:IPR034762" /db_xref="SubtiList:BG10144" /db_xref="UniProtKB/Swiss-Prot:P37477" /translation="MSQEEHNHEELNDQLQVRRDKMNQLRDNGIDPFGARFERTHQSQ EVISAYQDLTKEELEEKAIEVTIAGRMMTKRGKGKAGFAHLQDLEGQIQIYVRKDSVG DDQYEIFKSSDLGDLIGVTGKVFKTNVGELSVKATSFELLTKALRPLPDKYHGLKDVE QRYRQRYLDLIVNPDSKHTFITRSKIIQAMRRYLDDHGYLEVETPTMHSIPGGASARP FITHHNALDIPLYMRIAIELHLKRLIVGGLEKVYEIGRVFRNEGVSTRHNPEFTMIEL YEAYADYKDIMSLTENLVAHIAQEVLGTTTIQYGEEQIDLKPEWKRIHMVDAVKEATG VDFWEEVTVEQAREYAKEHEVEIKDSMTVGHIINEFFEQKIEETLIQPTFIYGHPVEI SPLAKKNPEDPRFTDRFELFIVGREHANAFTELNDPIDQRERFEAQLKEREAGNDEAH LMDEDFVEALEYGMPPTGGLGIGIDRLVMLLTNAPSIRDVLLFPQMRQR*" /label="lysS CDS" gene 88318..89817 /gene="lysS" /locus_tag="BSU_00820" /old_locus_tag="BSU00820" /label="lysS gene" promotor_-10 complement(89141..89159) /Source="Nicolas_upshift_promotors" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(89157) /Source="Nicolas_upshifts" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(89175..89180) /Source="Nicolas_upshift_promotors" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 89798 /Source="Nicolas_upshifts" /id="D36" /incds=0 /nref=104 /ntot=219 /MaxReadThrough="4.49559" /MaxDrop="4.89484" /score="4.33485487" /energy="-18.1" /TU="U76" /idTUdmin="U74" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-35 89893..89900 /Source="Nicolas_upshift_promotors" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 89909..90126 /Source="Nicolas_S_feature" /locus_tag="new_90318_90535" /HighExp="LBGstat, H2O2, Oxctl, Diami, dia15, Paraq, MG 25, Heat, MG 15, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 0.998, 1, 1, 0.999, 1" /label="S43" upshifts 89909 /Source="Nicolas_upshifts" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 89914..89933 /Source="Nicolas_upshift_promotors" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(89959) /Source="Nicolas_upshifts" /id="D37" /incds=0 /nref=3 /ntot=51 /MaxReadThrough="3.16217" /MaxDrop="5.0092" /score="18.6635354" /energy="-16.9" /TU="NA" /idTUdmin="U77" /TUdmin="-2288" /isTUend="FALSE" /label="downshifts" rRNA 90127..91680 /gene="rrnJ-16S" /locus_tag="BSU_rRNA_6" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnJ-16S rRNA" gene 90127..91680 /gene="rrnJ-16S" /locus_tag="BSU_rRNA_6" /label="rrnJ-16S gene" rRNA 91845..94772 /gene="rrnJ-23S" /locus_tag="BSU_rRNA_7" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnJ-23S rRNA" gene 91845..94772 /gene="rrnJ-23S" /locus_tag="BSU_rRNA_7" /label="rrnJ-23S gene" rRNA 94828..94945 /gene="rrnJ-5S" /locus_tag="BSU_rRNA_8" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnJ-5S rRNA" gene 94828..94945 /gene="rrnJ-5S" /locus_tag="BSU_rRNA_8" /label="rrnJ-5S gene" tRNA 94966..95041 /gene="trnJ-Val" /locus_tag="BSU_tRNA_12" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Val tRNA" gene 94966..95041 /gene="trnJ-Val" /locus_tag="BSU_tRNA_12" /label="trnJ-Val gene" tRNA 95046..95121 /gene="trnJ-Thr" /locus_tag="BSU_tRNA_13" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Thr tRNA" gene 95046..95121 /gene="trnJ-Thr" /locus_tag="BSU_tRNA_13" /label="trnJ-Thr gene" tRNA 95158..95233 /gene="trnJ-Lys" /locus_tag="BSU_tRNA_14" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Lys(UUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Lys tRNA" gene 95158..95233 /gene="trnJ-Lys" /locus_tag="BSU_tRNA_14" /label="trnJ-Lys gene" tRNA 95240..95322 /gene="trnJ-Leu1" /locus_tag="BSU_tRNA_15" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Leu1 tRNA" gene 95240..95322 /gene="trnJ-Leu1" /locus_tag="BSU_tRNA_15" /label="trnJ-Leu1 gene" tRNA 95363..95437 /gene="trnJ-Gly" /locus_tag="BSU_tRNA_16" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(GCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Gly tRNA" gene 95363..95437 /gene="trnJ-Gly" /locus_tag="BSU_tRNA_16" /label="trnJ-Gly gene" tRNA 95452..95537 /gene="trnJ-Leu2" /locus_tag="BSU_tRNA_17" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Leu2 tRNA" gene 95452..95537 /gene="trnJ-Leu2" /locus_tag="BSU_tRNA_17" /label="trnJ-Leu2 gene" tRNA 95547..95623 /gene="trnJ-Arg" /locus_tag="BSU_tRNA_18" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="arginine transfer RNA(ACG); Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27749819; Product type n : RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Arg tRNA" gene 95547..95623 /gene="trnJ-Arg" /locus_tag="BSU_tRNA_18" /label="trnJ-Arg gene" tRNA 95651..95727 /gene="trnJ-Pro" /locus_tag="BSU_tRNA_19" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Pro(UGG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Pro tRNA" gene 95651..95727 /gene="trnJ-Pro" /locus_tag="BSU_tRNA_19" /label="trnJ-Pro gene" tRNA 95737..95812 /gene="trnJ-Ala" /locus_tag="BSU_tRNA_20" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Ala tRNA" gene 95737..95812 /gene="trnJ-Ala" /locus_tag="BSU_tRNA_20" /label="trnJ-Ala gene" rRNA 95983..97536 /gene="rrnW-16S" /locus_tag="BSU_rRNA_9" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnW-16S rRNA" gene 95983..97536 /gene="rrnW-16S" /locus_tag="BSU_rRNA_9" /label="rrnW-16S gene" rRNA 97701..100628 /gene="rrnW-23S" /locus_tag="BSU_rRNA_10" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnW-23S rRNA" gene 97701..100628 /gene="rrnW-23S" /locus_tag="BSU_rRNA_10" /label="rrnW-23S gene" rRNA 100684..100802 /gene="rrnW-5S" /locus_tag="BSU_rRNA_11" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnW-5S rRNA" gene 100684..100802 /gene="rrnW-5S" /locus_tag="BSU_rRNA_11" /label="rrnW-5S gene" S_feature 100803..100880 /Source="Nicolas_S_feature" /locus_tag="new_101212_101289" /HighExp="G135, G180, G150, Cold, Paraq, Oxctl, H2O2, C30, BMM, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S44" promotor_-35 100850..100853 /Source="Nicolas_upshift_promotors" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 100869..100888 /Source="Nicolas_upshift_promotors" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 100882 /Source="Nicolas_upshifts" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-35 100916..100922 /Source="Nicolas_upshift_promotors" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="promotor_-35" promotor_-10 100936..100955 /Source="Nicolas_upshift_promotors" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="promotor_-10" upshifts 100947 /Source="Nicolas_upshifts" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="upshifts" promotor_-35 100962..100969 /Source="Nicolas_upshift_promotors" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 100983..101002 /Source="Nicolas_upshift_promotors" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 100995 /Source="Nicolas_upshifts" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 101040..101504 /gene="ctsR" /locus_tag="BSU_00830" /old_locus_tag="BSU00830" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2120829, 9852015, 11069659, 12618461, 16163393, 20852588, 24465625, 27388279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2120829, 9852015, 11069659, 12618461, 16163393, 20852588, 24465625, 27388279; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of class III stress genes" /protein_id="NP_387964.1" /db_xref="EnsemblGenomes-Gn:BSU00830" /db_xref="EnsemblGenomes-Tr:CAB11859" /db_xref="GOA:P37568" /db_xref="InterPro:IPR008463" /db_xref="SubtiList:BG10145" /db_xref="UniProtKB/Swiss-Prot:P37568" /translation="MGHNISDIIEQYLKRVLDQNGKEILEIKRSEIADKFQCVPSQIN YVINTRFTSERGYIVESKRGGGGYIRIIKIKMNNEVVLINNIISQINTHLSQAASDDI ILRLLEDKVISEREAKMMVSVMDRSVLHIDLPERDELRARMMKAMLTSLKLK*" /label="ctsR CDS" gene 101040..101504 /gene="ctsR" /locus_tag="BSU_00830" /old_locus_tag="BSU00830" /label="ctsR gene" misc_feature complement(101151..101155) /Source="Nicolas_upshift_promotors" /id="U82" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.811188811188811" /psig="0.0769230769230769" /xcortree=50 /SigmaFactorBS="caacaatatatcctctttcgcttgtaaatctggtgttgatga cataatttatttgggaaggaACGCAttgaaatttatctgcaatttcacttcgtttaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(101157) /Source="Nicolas_upshifts" /id="U82" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.811188811188811" /psig="0.0769230769230769" /xcortree=50 /SigmaFactorBS="caacaatatatcctctttcgcttgtaaatctggtgttgatga cataatttatttgggaaggaACGCAttgaaatttatctgcaatttcacttcgtttaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 101518..102075 /gene="mcsA" /locus_tag="BSU_00840" /old_locus_tag="BSU00840" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16163393, 19189946, 24947607" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16163393, 19189946, 24947607; Product type f: factor" /codon_start=1 /transl_table=11 /product="activator of protein kinase McsB" /protein_id="NP_387965.1" /db_xref="EnsemblGenomes-Gn:BSU00840" /db_xref="EnsemblGenomes-Tr:CAB11860" /db_xref="GOA:P37569" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR025542" /db_xref="InterPro:IPR029037" /db_xref="InterPro:IPR036876" /db_xref="SubtiList:BG10146" /db_xref="UniProtKB/Swiss-Prot:P37569" /translation="MICQECHERPATFHFTKVVNGEKIEVHICEQCAKENSDSYGISA NQGFSIHNLLSGLLNMDSSFQNAGTQMFSHSEQISACPKCGMTFQQFRKIGRFGCSEC YKTFHSNITPILRKVHSGNTVHAGKIPKRIGGNLHVRRQIDMLKKELESLIHQEEFEN AAHVRDQIRLLEQSLKSTDSEEEQE*" /label="mcsA CDS" gene 101518..102075 /gene="mcsA" /locus_tag="BSU_00840" /old_locus_tag="BSU00840" /label="mcsA gene" CDS 102075..103166 /gene="mcsB" /locus_tag="BSU_00850" /old_locus_tag="BSU00850" /EC_number="2.7.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16163393, 17380125, 19189946, 21622759, 25610436, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16163393, 17380125, 19189946, 21622759, 25610436, 27749819; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein arginine kinase" /protein_id="NP_387966.1" /db_xref="EnsemblGenomes-Gn:BSU00850" /db_xref="EnsemblGenomes-Tr:CAB11861" /db_xref="GOA:P37570" /db_xref="InterPro:IPR000749" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR022414" /db_xref="InterPro:IPR022415" /db_xref="InterPro:IPR023660" /db_xref="SubtiList:BG10147" /db_xref="UniProtKB/Swiss-Prot:P37570" /translation="MSLKHFIQDALSSWMKQKGPESDIVLSSRIRLARNFEHIRFPTR YSNEEASSIIQQFEDQFSEQEIPGIGKFVLIRMNDAQPLEKRVLVEKHLISPNLTESP FGGCLLSENEEVSVMLNEEDHIRIQCLFPGFQLLEAMKAANQVDDWIEEKVDYAFNEQ RGYLTSCPTNVGTGLRASVMMHLPALVLTRQINRIIPAINQLGLVVRGIYGEGSEAVG NIFQISNQITLGKSEQDIVEDLNSVAAQLIEQERSAREAIYQTSKIELEDRVYRSYGV LSNCRMIESKETAKCLSDVRLGIDLGIIKGLSSNILNELMILTQPGFLQQYSGGALRP NERDIRRAALIRERLHLEMNGKRQEDESI*" /label="mcsB CDS" gene 102075..103166 /gene="mcsB" /locus_tag="BSU_00850" /old_locus_tag="BSU00850" /label="mcsB gene" CDS 103163..105595 /gene="clpC" /locus_tag="BSU_00860" /old_locus_tag="BSU00860" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12354604, 15529410, 16525504, 26735940, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354604, 15529410, 16525504, 26735940, 27749819; Product type f: factor" /codon_start=1 /transl_table=11 /product="class III stress response-related ATPase, AAA+ superfamily" /protein_id="NP_387967.1" /db_xref="EnsemblGenomes-Gn:BSU00860" /db_xref="EnsemblGenomes-Tr:CAB11862" /db_xref="GOA:P37571" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004176" /db_xref="InterPro:IPR018368" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028299" /db_xref="InterPro:IPR036628" /db_xref="PDB:2K77" /db_xref="PDB:2Y1Q" /db_xref="PDB:2Y1R" /db_xref="PDB:3J3R" /db_xref="PDB:3J3S" /db_xref="PDB:3J3T" /db_xref="PDB:3J3U" /db_xref="PDB:3PXG" /db_xref="PDB:3PXI" /db_xref="PDB:5HBN" /db_xref="SubtiList:BG10148" /db_xref="UniProtKB/Swiss-Prot:P37571" /translation="MMFGRFTERAQKVLALAQEEALRLGHNNIGTEHILLGLVREGEG IAAKALQALGLGSEKIQKEVESLIGRGQEMSQTIHYTPRAKKVIELSMDEARKLGHSY VGTEHILLGLIREGEGVAARVLNNLGVSLNKARQQVLQLLGSNETGSSAAGTNSNANT PTLDSLARDLTAIAKEDSLDPVIGRSKEIQRVIEVLSRRTKNNPVLIGEPGVGKTAIA EGLAQQIINNEVPEILRDKRVMTLDMGTVVAGTKYRGEFEDRLKKVMDEIRQAGNIIL FIDELHTLIGAGGAEGAIDASNILKPSLARGELQCIGATTLDEYRKYIEKDAALERRF QPIQVDQPSVDESIQILQGLRDRYEAHHRVSITDDAIEAAVKLSDRYISDRFLPDKAI DLIDEAGSKVRLRSFTTPPNLKELEQKLDEVRKEKDAAVQSQEFEKAASLRDTEQRLR EQVEDTKKSWKEKQGQENSEVTVDDIAMVVSSWTGVPVSKIAQTETDKLLNMENILHS RVIGQDEAVVAVAKAVRRARAGLKDPKRPIGSFIFLGPTGVGKTELARALAESIFGDE ESMIRIDMSEYMEKHSTSRLVGSPPGYVGYDEGGQLTEKVRRKPYSVVLLDEIEKAHP DVFNILLQVLEDGRLTDSKGRTVDFRNTILIMTSNVGASELKRNKYVGFNVQDETQNH KDMKDKVMGELKRAFRPEFINRIDEIIVFHSLEKKHLTEIVSLMSDQLTKRLKEQDLS IELTDAAKAKVAEEGVDLEYGARPLRRAIQKHVEDRLSEELLRGNIHKGQHIVLDVED GEFVVKTTAKTN*" /label="clpC CDS" gene 103163..105595 /gene="clpC" /locus_tag="BSU_00860" /old_locus_tag="BSU00860" /label="clpC gene" downshifts 105590 /Source="Nicolas_upshifts" /id="D38" /incds=0 /nref=57 /ntot=245 /MaxReadThrough="6.69446" /MaxDrop="4.4703" /score="-8.32149463" /energy="-11.7" /TU="U80,U81" /idTUdmin="U79" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS 105687..107063 /gene="radA" /locus_tag="BSU_00870" /old_locus_tag="BSU00870" /EC_number="2.1.1.63" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10931349, 11810266, 15317759, 25616256; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA repair protein; 6-O-methylguanine-DNA methyltransferase" /protein_id="NP_387968.1" /db_xref="EnsemblGenomes-Gn:BSU00870" /db_xref="EnsemblGenomes-Tr:CAB11863" /db_xref="GOA:P37572" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004504" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020588" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10149" /db_xref="UniProtKB/Swiss-Prot:P37572" /translation="MAKTKSKFICQSCGYESPKWMGKCPGCGAWNTMVEEMIKKAPAN RRAAFSHSVQTVQKPSPITSIETSEEPRVKTQLGEFNRVLGGGVVKGSLVLIGGDPGI GKSTLLLQVSAQLSGSSNSVLYISGEESVKQTKLRADRLGINNPSLHVLSETDMEYIS SAIQEMNPSFVVVDSIQTVYQSDITSAPGSVSQVRECTAELMKIAKTKGIPIFIVGHV TKEGSIAGPRLLEHMVDTVLYFEGERHHTFRILRAVKNRFGSTNEMGIFEMREEGLTE VLNPSEIFLEERSAGSAGSSITASMEGTRPILVEIQALISPTSFGNPRRMATGIDHNR VSLLMAVLEKRVGLLLQNQDAYLKVAGGVKLDEPAIDLAIVISIASSFRDTPPNPADC FIGEVGLTGEVRRVSRIEQRVKEAAKLGFKRMIIPAANLDGWTKPKGIEVIGVANVAE ALRTSLGG*" /label="radA CDS" gene 105687..107063 /gene="radA" /locus_tag="BSU_00870" /old_locus_tag="BSU00870" /label="radA gene" promotor_-35 106142..106151 /Source="Nicolas_upshift_promotors" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 106164..106179 /Source="Nicolas_upshift_promotors" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 106167 /Source="Nicolas_upshifts" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 107067..108149 /gene="disA" /locus_tag="BSU_00880" /old_locus_tag="BSU00880" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16713562, 21566650, 24939848, 25616256, 27074767, 27150552, 28511132, 28961460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16713562, 21566650, 24939848, 25616256, 27074767, 27150552, 28511132, 28961460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diadenylate cyclase; DNA integrity scanning protein; cell cycle checkpoint DNA scanning protein" /protein_id="NP_387969.1" /db_xref="EnsemblGenomes-Gn:BSU00880" /db_xref="EnsemblGenomes-Tr:CAB11864" /db_xref="GOA:P37573" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR018906" /db_xref="InterPro:IPR023763" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG10150" /db_xref="UniProtKB/Swiss-Prot:P37573" /translation="MEKEKKGAKHELDLSSILQFVAPGTPLRAGMENVLRANTGGLIV VGYNDKVKEVVDGGFHINTAFSPAHLYELAKMDGAIILSDSGQKILYANTQLMPDATI SSSETGMRHRTAERVAKQTGCLVIAISERRNVITLYQENMKYTLKDIGFILTKANQAI QTLEKYKTILDKTINALNALEFEELVTFSDVLSVMHRYEMVLRIKNEINMYIKELGTE GHLIKLQVIELITDMEEEAALFIKDYVKEKIKDPFVLLKELQDMSSYDLLDDSIVYKL LGYPASTNLDDYVLPRGYRLLNKIPRLPMPIVENVVEAFGVLPRIIEASAEELDEVEG IGEVRAQKIKKGLKRLQEKHYLDRQL*" /label="disA CDS" gene 107067..108149 /gene="disA" /locus_tag="BSU_00880" /old_locus_tag="BSU00880" /label="disA gene" S_feature 108150..108264 /Source="Nicolas_S_feature" /locus_tag="new_108559_108673" /HighExp="Etha, Salt, Heat, dia15, Diami, M9-stat, B60, T-0.40H, T-1.10H, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA, SigB" /TUshortPSig="1, 1, 1" /TUlongSig="SigA" /TUlongPSig="0.947" /label="S45" CDS 108265..109365 /gene="yacL" /locus_tag="BSU_00890" /old_locus_tag="BSU00890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26999498; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein possibly involved in RNA binding" /protein_id="NP_387970.1" /db_xref="EnsemblGenomes-Gn:BSU00890" /db_xref="EnsemblGenomes-Tr:CAB11865" /db_xref="GOA:Q06754" /db_xref="InterPro:IPR002716" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR029060" /db_xref="SubtiList:BG10151" /db_xref="UniProtKB/Swiss-Prot:Q06754" /translation="MLKRIVQAFFIIFGGVVGIFLIPELFVLLNIQDIPLITNAYTSA AIGAIIFFLISIWGTEYVVNWVKWIEDSLLKAPVPDLLFGSLGLVFGLIIAYLIVNVI PLDNIPYRIFSTIIPVFLAFFLGYLGFQVGFKKKDELISLFSISARMQKKKGTADEEH EVQDKKLKILDTSVIIDGRIADICQTGFLEGVIVIPQFVLEELQHIADSSDVLKRNRG RRGLDILNRIQKELDIEVEIYEGDFEDIQEVDSKLVKLAKLTSGVVVTNDFNLNKVCE LQKVAVLNINDLANAVKPVVLPGEEMNVQVIKDGKEHNQGVAYLDDGTMIVVEEGRNY IGKHIDVLVTSVLQTAAGRMIFAKPKLLEKAL*" /label="yacL CDS" gene 108265..109365 /gene="yacL" /locus_tag="BSU_00890" /old_locus_tag="BSU00890" /label="yacL gene" downshifts complement(109187) /Source="Nicolas_upshifts" /id="D39" /incds=1 /nref=1 /ntot=103 /MaxReadThrough="0.39171" /MaxDrop="2.87304" /score="-9.71423487" /energy="-11.8" /TU="NA" /idTUdmin="U82" /TUdmin="-8228" /isTUend="FALSE" /label="downshifts" CDS 109380..110078 /gene="ispD" /locus_tag="BSU_00900" /old_locus_tag="BSU00900" /EC_number="2.7.7.60" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15044829, 15379557, 16533036, 17081012, 17458547, 23840410, 27821871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15044829, 15379557, 16533036, 17081012, 17458547, 23840410, 27821871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, nonmevalonate isoprenoid pathway" /protein_id="NP_387971.1" /db_xref="EnsemblGenomes-Gn:BSU00900" /db_xref="EnsemblGenomes-Tr:CAB11866" /db_xref="GOA:Q06755" /db_xref="InterPro:IPR001228" /db_xref="InterPro:IPR018294" /db_xref="InterPro:IPR029044" /db_xref="InterPro:IPR034683" /db_xref="PDB:5DDT" /db_xref="PDB:5DDV" /db_xref="PDB:5HS2" /db_xref="SubtiList:BG10152" /db_xref="UniProtKB/Swiss-Prot:Q06755" /translation="MSYDVVIPAAGQGKRMKAGRNKLFIELKGDPVIIHTLRVFDSHR QCDKIILVINEQEREHFQQLLSDYPFQTSIELVAGGDERQHSVYKGLKAVKQEKIVLV HDGARPFIKHEQIDELIAEAEQTGAAILAVPVKDTIKRVQDLQVSETIERSSLWAVQT PQAFRLSLLMKAHAEAERKGFLGTDDASLVEQMEGGSVRVVEGSYTNIKLTTPDDLTS AEAIMESESGNKHV*" /label="ispD CDS" gene 109380..110078 /gene="ispD" /locus_tag="BSU_00900" /old_locus_tag="BSU00900" /label="ispD gene" CDS 110071..110547 /gene="ispF" /locus_tag="BSU_00910" /old_locus_tag="BSU00910" /EC_number="4.6.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9622350, 11997478, 12270818, 12682299, 17458547, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 11997478, 12270818, 12682299, 17458547, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase" /protein_id="NP_387972.1" /db_xref="EnsemblGenomes-Gn:BSU00910" /db_xref="EnsemblGenomes-Tr:CAB11867" /db_xref="GOA:Q06756" /db_xref="InterPro:IPR003526" /db_xref="InterPro:IPR020555" /db_xref="InterPro:IPR036571" /db_xref="PDB:5IWX" /db_xref="PDB:5IWY" /db_xref="SubtiList:BG10153" /db_xref="UniProtKB/Swiss-Prot:Q06756" /translation="MFRIGQGFDVHQLVEGRPLIIGGIEIPYEKGLLGHSDADVLLHT VADACLGAVGEGDIGKHFPDTDPEFKDADSFKLLQHVWGIVKQKGYVLGNIDCTIIAQ KPKMLPYIEDMRKRIAEGLEADVSQVNVKATTTEKLGFTGRAEGIAAQATVLIQKG*" /label="ispF CDS" gene 110071..110547 /gene="ispF" /locus_tag="BSU_00910" /old_locus_tag="BSU00910" /label="ispF gene" promotor_-35 110551..110558 /Source="Nicolas_upshift_promotors" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 110572..110591 /Source="Nicolas_upshift_promotors" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 110585 /Source="Nicolas_upshifts" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 110638..112089 /gene="gltX" /locus_tag="BSU_00920" /old_locus_tag="BSU00920" /EC_number="6.1.1.24" /EC_number="6.1.1.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2120226, 3079749, 9342321, 10024179, 10546897, 12682299, 14741355" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2120226, 3079749, 9342321, 10024179, 10546897, 12682299, 14741355; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA synthetase" /protein_id="NP_387973.1" /db_xref="EnsemblGenomes-Gn:BSU00920" /db_xref="EnsemblGenomes-Tr:CAB11868" /db_xref="GOA:P22250" /db_xref="InterPro:IPR000924" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR004527" /db_xref="InterPro:IPR008925" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR020058" /db_xref="InterPro:IPR020061" /db_xref="InterPro:IPR020751" /db_xref="InterPro:IPR020752" /db_xref="InterPro:IPR033910" /db_xref="SubtiList:BG10154" /db_xref="UniProtKB/Swiss-Prot:P22250" /translation="MGNEVRVRYAPSPTGHLHIGNARTALFNYLFARNQGGKFIIRVE DTDKKRNIEGGEQSQLNYLKWLGIDWDESVDVGGEYGPYRQSERNDIYKVYYEELLEK GLAYKCYCTEEELEKEREEQIARGEMPRYSGKHRDLTQEEQEKFIAEGRKPSIRFRVP EGKVIAFNDIVKGEISFESDGIGDFVIVKKDGTPTYNFAVAIDDYLMKMTHVLRGEDH ISNTPKQIMIYQAFGWDIPQFGHMTLIVNESRKKLSKRDESIIQFIEQYKELGYLPEA LFNFIGLLGWSPVGEEELFTKEQFIEIFDVNRLSKSPALFDMHKLKWVNNQYVKKLDL DQVVELTLPHLQKAGKVGTELSAEEQEWVRKLISLYHEQLSYGAEIVELTDLFFTDEI EYNQEAKAVLEEEQVPEVLSTFAAKLEELEEFTPDNIKASIKAVQKETGHKGKKLFMP IRVAVTGQTHGPELPQSIELIGKETAIQRLKNI*" /label="gltX CDS" gene 110638..112089 /gene="gltX" /locus_tag="BSU_00920" /old_locus_tag="BSU00920" /label="gltX gene" promotor_-35 111567..111576 /Source="Nicolas_upshift_promotors" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="promotor_-35" promotor_-10 111590..111609 /Source="Nicolas_upshift_promotors" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="promotor_-10" upshifts 111590 /Source="Nicolas_upshifts" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="upshifts" S_feature 112090..112390 /Source="Nicolas_S_feature" /locus_tag="new_112499_112799" /HighExp="S6, S8, S7, Diami, C90, LBGexp, G135, H2O2, dia5, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.17844199999999999" /TUshortSig="SigK, SigA, SigWXY" /TUshortPSig="1, 0.999, 1" /TUlongSig="SigA, SigB, SigA" /TUlongPSig="1, 1, 0.947" /label="S46" CDS 112391..113044 /gene="cysE" /locus_tag="BSU_00930" /old_locus_tag="BSU00930" /EC_number="2.3.1.30" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7510287, 10737181, 10939241, 17056751, 18974048, 25731080" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7510287, 10737181, 10939241, 17056751, 18974048, 25731080; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="serine O-acetyltransferase" /protein_id="NP_387974.1" /db_xref="EnsemblGenomes-Gn:BSU00930" /db_xref="EnsemblGenomes-Tr:CAB11869" /db_xref="GOA:Q06750" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR005881" /db_xref="InterPro:IPR010493" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="SubtiList:BG10155" /db_xref="UniProtKB/Swiss-Prot:Q06750" /translation="MFFRMLKEDIDTVFDQDPAARSYFEVILTYSGLHAIWAHRIAHA LYKRKFYFLARLISQVSRFFTGIEIHPGATIGRRFFIDHGMGVVIGETCEIGNNVTVF QGVTLGGTGKEKGKRHPTIKDDALIATGAKVLGSITVGEGSKIGAGSVVLHDVPDFST VVGIPGRVVVQNGKKVRRDLNHQDLPDPVADRFKSLEQQILELKAELEDRKERINQK* " /label="cysE CDS" gene 112391..113044 /gene="cysE" /locus_tag="BSU_00930" /old_locus_tag="BSU00930" /label="cysE gene" CDS 113041..114441 /gene="cysS" /locus_tag="BSU_00940" /old_locus_tag="BSU00940" /EC_number="6.1.1.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10024179, 10546897, 10931887, 12682299, 29079736" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10024179, 10546897, 10931887, 12682299, 29079736; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dual cysteinyl-tRNA synthetase; cysteine persulfide synthase" /protein_id="NP_387975.1" /db_xref="EnsemblGenomes-Gn:BSU00940" /db_xref="EnsemblGenomes-Tr:CAB11870" /db_xref="GOA:Q06752" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015273" /db_xref="InterPro:IPR015803" /db_xref="InterPro:IPR024909" /db_xref="InterPro:IPR032678" /db_xref="SubtiList:BG10156" /db_xref="UniProtKB/Swiss-Prot:Q06752" /translation="MTITLYNTLTRQKETFVPLEEGKVKMYVCGPTVYNYIHIGNARP AIVYDTVRNYLEYKGYDVQYVSNFTDVDDKLIKAANELGEDVPTISERFIKAYFEDVG ALGCRKADLHPRVMENMDAIIEFVDQLVKKGYAYESEGDVYFKTRAFEGYGKLSQQSI DELRSGARIRVGEKKEDALDFALWKAAKEGEISWDSPWGKGRPGWHIECSAMVKKYLG DQIDIHAGGQDLTFPHHENEIAQSEALTGKTFAKYWLHNGYINIDNEKMSKSLGNFVL VHDIIKQHDPQLLRFFMLSVHYRHPINYSEELLENTKSAFSRLKTAYSNLQHRLNSST NLTEDDDQWLEKVEEHRKAFEEEMDDDFNTANAISVLFDLAKHANYYLQKDHTADHVI TAFIEMFDRIVSVLGFSLGEQELLDQEIEDLIEKRNEARRNRDFALSDQIRDQLKSMN IILEDTAQGTRWKRGE*" /label="cysS CDS" gene 113041..114441 /gene="cysS" /locus_tag="BSU_00940" /old_locus_tag="BSU00940" /label="cysS gene" CDS 114445..114876 /gene="mrnC" /locus_tag="BSU_00950" /old_locus_tag="BSU00950" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 25634891, 27924926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 25634891, 27924926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease for 23S RNA maturation, mini-RNase III" /protein_id="NP_387976.1" /db_xref="EnsemblGenomes-Gn:BSU00950" /db_xref="EnsemblGenomes-Tr:CAB11871" /db_xref="GOA:O31418" /db_xref="InterPro:IPR000999" /db_xref="InterPro:IPR008226" /db_xref="InterPro:IPR036389" /db_xref="PDB:4OUN" /db_xref="SubtiList:BG12702" /db_xref="UniProtKB/Swiss-Prot:O31418" /translation="MLEFDTIKDSKQLNGLALAYIGDAIFEVYVRHHLLKQGFTKPND LHKKSSRIVSAKSQAEILFFLQNQSFFTEEEEAVLKRGRNAKSGTTPKNTDVQTYRYS TAFEALLGYLFLEKKEERLSQLVAEAIQFGTSGRKTNESAT*" /label="mrnC CDS" gene 114445..114876 /gene="mrnC" /locus_tag="BSU_00950" /old_locus_tag="BSU00950" /label="mrnC gene" CDS 114860..115609 /gene="rlmB" /locus_tag="BSU_00960" /old_locus_tag="BSU00960" /EC_number="2.1.1.185" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11698387, 12377117, 16014871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA (Gm2251)-methyltransferase" /protein_id="NP_387977.1" /db_xref="EnsemblGenomes-Gn:BSU00960" /db_xref="EnsemblGenomes-Tr:CAB11872" /db_xref="GOA:Q06753" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR004441" /db_xref="InterPro:IPR013123" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="InterPro:IPR029064" /db_xref="SubtiList:BG10157" /db_xref="UniProtKB/Swiss-Prot:Q06753" /translation="MSQQHDYVIGKNAVIETLKSDRKLYKLWMAENTVKGQAQQVIEL AKKQGITIQYVPRKKLDQMVTGQHQGVVAQVAAYEYAELDDLYKAAEEKNEQPFFLIL DELEDPHNLGSIMRTADAVGAHGIVIPKRRAVGLTTTVAKASTGAIEHIPVARVTNLA RTLEEMKERGIWVVGTDASAREDFRNMDGNMPLALVIGSEGKGMGRLVKEKCDFLIKL PMAGKVTSLNASVAAGLLMYEVYRKRNPVGE*" /label="rlmB CDS" gene 114860..115609 /gene="rlmB" /locus_tag="BSU_00960" /old_locus_tag="BSU00960" /label="rlmB gene" CDS 115616..116128 /gene="raeA" /locus_tag="BSU_00970" /old_locus_tag="BSU00970" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:17114934, 23355615, 28363943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17114934, 23355615, 28363943; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-dependent mRNA endonuclease" /protein_id="NP_387978.1" /db_xref="EnsemblGenomes-Gn:BSU00970" /db_xref="EnsemblGenomes-Tr:CAB11873" /db_xref="InterPro:IPR010298" /db_xref="PDB:5MQ8" /db_xref="PDB:5MQ9" /db_xref="SubtiList:BG10158" /db_xref="UniProtKB/Swiss-Prot:P37574" /translation="MDILLVDGYNMIGAWPQLKDLKANSFEEARDVLIQKMAEYQSYT GNRVIVVFDAHLVKGLEKKQTNHRVEVIFTKENETADERIEKLAQALNNIATQIHVAT SDYTEQWAIFGQGALRKSARELLREVETIERRIERRVRKITSEKPAGKIALSEEVLKT FEKWRRGDLD*" /label="raeA CDS" gene 115616..116128 /gene="raeA" /locus_tag="BSU_00970" /old_locus_tag="BSU00970" /label="raeA gene" promotor_-35 116127..116134 /Source="Nicolas_upshift_promotors" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 116149..116168 /Source="Nicolas_upshift_promotors" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 116151 /Source="Nicolas_upshifts" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 116191..116847 /gene="sigH" /locus_tag="BSU_00980" /old_locus_tag="BSU00980" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169614, 16339734, 25288929, 26712348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169614, 16339734, 25288929, 26712348; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-30 factor (sigma(H))" /protein_id="NP_387979.1" /db_xref="EnsemblGenomes-Gn:BSU00980" /db_xref="EnsemblGenomes-Tr:CAB11874" /db_xref="GOA:P17869" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014218" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR016371" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10159" /db_xref="UniProtKB/Swiss-Prot:P17869" /translation="MNLQNNKGKFNKEQFCQLEDEQVIEKVHVGDSDALDYLITKYRN FVRAKARSYFLIGADREDIVQEGMIGLYKSIRDFKEDKLTSFKAFAELCITRQIITAI KTATRQKHIPLNSYASLDKPIFDEESDRTLLDVISGAKTLNPEEMIINQEEFDDIEMK MGELLSDLERKVLVLYLDGRSYQEISDELNRHVKSIDNALQRVKRKLEKYLEIREISL *" /label="sigH CDS" gene 116191..116847 /gene="sigH" /locus_tag="BSU_00980" /old_locus_tag="BSU00980" /label="sigH gene" downshifts complement(116645) /Source="Nicolas_upshifts" /id="D40" /incds=1 /nref=1 /ntot=107 /MaxReadThrough="2.38622" /MaxDrop="2.50464" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U87" /TUdmin=836 /isTUend="FALSE" /label="downshifts" S_feature 116848..116939 /Source="Nicolas_S_feature" /locus_tag="new_117257_117348" /HighExp="T4.0H, T3.30H, T3.0H, T2.30H, S1, S2, T5.0H, HiOs, T2.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigK, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 1, 1, 0.947" /label="S47" CDS 116940..117089 /gene="rpmGB" /locus_tag="BSU_00990" /old_locus_tag="BSU00990" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14586115, 19648245, 23002217, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14586115, 19648245, 23002217, 27561249; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L33" /protein_id="NP_387980.1" /db_xref="EnsemblGenomes-Gn:BSU00990" /db_xref="EnsemblGenomes-Tr:CAB11875" /db_xref="GOA:Q06798" /db_xref="InterPro:IPR001705" /db_xref="InterPro:IPR011332" /db_xref="InterPro:IPR018264" /db_xref="SubtiList:BG10160" /db_xref="UniProtKB/Swiss-Prot:Q06798" /translation="MRKKITLACKTCGNRNYTTMKSSASAAERLEVKKYCSTCNSHTA HLETK*" /label="rpmGB CDS" gene 116940..117089 /gene="rpmGB" /locus_tag="BSU_00990" /old_locus_tag="BSU00990" /label="rpmGB gene" CDS 117123..117302 /gene="secE" /locus_tag="BSU_01000" /old_locus_tag="BSU01000" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11976315, 12682299, 16242710, 22304380, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11976315, 12682299, 16242710, 22304380, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_387981.1" /db_xref="EnsemblGenomes-Gn:BSU01000" /db_xref="EnsemblGenomes-Tr:CAB11876" /db_xref="GOA:Q06799" /db_xref="InterPro:IPR001901" /db_xref="InterPro:IPR005807" /db_xref="InterPro:IPR022943" /db_xref="SubtiList:BG10161" /db_xref="UniProtKB/Swiss-Prot:Q06799" /translation="MRIMKFFKDVGKEMKKVSWPKGKELTRYTITVISTVIFFVIFFA LLDTGISQLIRLIVE*" /label="secE CDS" gene 117123..117302 /gene="secE" /locus_tag="BSU_01000" /old_locus_tag="BSU01000" /label="secE gene" S_feature 117303..117480 /Source="Nicolas_S_feature" /locus_tag="new_117712_117889" /HighExp="Cold, G180, G150, H2O2, LoTm, Oxctl, G135, Paraq, LBGexp, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigK, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 1, 1, 0.947" /label="S48" downshifts complement(117474) /Source="Nicolas_upshifts" /id="D41" /incds=0 /nref=37 /ntot=175 /MaxReadThrough="1.57397" /MaxDrop="4.03552" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U87" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS 117481..118014 /gene="nusG" /locus_tag="BSU_01010" /old_locus_tag="BSU01010" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11101662, 16014871, 16707701, 18852477, 26742846, 28507243" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11101662, 16014871, 16707701, 18852477, 26742846, 28507243; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA polymerase elongation pause factor" /protein_id="NP_387982.1" /db_xref="EnsemblGenomes-Gn:BSU01010" /db_xref="EnsemblGenomes-Tr:CAB11877" /db_xref="GOA:Q06795" /db_xref="InterPro:IPR001062" /db_xref="InterPro:IPR005824" /db_xref="InterPro:IPR006645" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR015869" /db_xref="InterPro:IPR036735" /db_xref="SubtiList:BG10162" /db_xref="UniProtKB/Swiss-Prot:Q06795" /translation="MEKNWYVVHTYSGYENKVKANLEKRVESMGMQDKIFRVVVPEEE ETDIKNGKKKVVKKKVFPGYVLVEIVMTDDSWYVVRNTPGVTGFVGSAGSGSKPTPLL PGEAETILKRMGMDERKTDIDFELKETVKVIDGPFANFTGSIEEIDYDKSKVKVFVNM FGRETPVELEFTQIDKL*" /label="nusG CDS" gene 117481..118014 /gene="nusG" /locus_tag="BSU_01010" /old_locus_tag="BSU01010" /label="nusG gene" upshifts complement(117569) /Source="Nicolas_upshifts" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(117572..117576) /Source="Nicolas_upshift_promotors" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(117591..117596) /Source="Nicolas_upshift_promotors" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 118025..118032 /Source="Nicolas_upshift_promotors" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" S_feature 118043..118181 /Source="Nicolas_S_feature" /locus_tag="new_118452_118590" /HighExp="T-1.40H, ferm, T-3.40H, T-5.40H, BI, B36, LoTm, SMM, T-2.40H, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S49" upshifts 118043 /Source="Nicolas_upshifts" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-10 118046..118065 /Source="Nicolas_upshift_promotors" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" CDS 118182..118607 /gene="rplK" /locus_tag="BSU_01020" /old_locus_tag="BSU01020" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11244072, 19653700, 20441189" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11244072, 19653700, 20441189; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L11 (BL11)" /protein_id="NP_387983.2" /db_xref="EnsemblGenomes-Gn:BSU01020" /db_xref="EnsemblGenomes-Tr:CAB11878" /db_xref="GOA:Q06796" /db_xref="InterPro:IPR000911" /db_xref="InterPro:IPR006519" /db_xref="InterPro:IPR020783" /db_xref="InterPro:IPR020784" /db_xref="InterPro:IPR020785" /db_xref="InterPro:IPR036769" /db_xref="InterPro:IPR036796" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="SubtiList:BG10163" /db_xref="UniProtKB/Swiss-Prot:Q06796" /translation="MAKKVVKVVKLQIPAGKANPAPPVGPALGQAGVNIMGFCKEFNA RTADQAGLIIPVEISVYEDRSFTFITKTPPAAVLLKKAAGIESGSGEPNRNKVATVKR DKVREIAETKMPDLNAADVEAAMRMVEGTARSMGIVIED*" /label="rplK CDS" gene 118182..118607 /gene="rplK" /locus_tag="BSU_01020" /old_locus_tag="BSU01020" /label="rplK gene" S_feature 118608..118701 /Source="Nicolas_S_feature" /locus_tag="new_119017_119110" /HighExp="HPh, LPh, Lbexp, G180, LBGexp, G150, Heat, Cold, Fru, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S50" CDS 118702..119400 /gene="rplA" /locus_tag="BSU_01030" /old_locus_tag="BSU01030" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16352840, 17981968, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L1 (BL1)" /protein_id="NP_387984.2" /db_xref="EnsemblGenomes-Gn:BSU01030" /db_xref="EnsemblGenomes-Tr:CAB11879" /db_xref="GOA:Q06797" /db_xref="InterPro:IPR002143" /db_xref="InterPro:IPR005878" /db_xref="InterPro:IPR016095" /db_xref="InterPro:IPR023673" /db_xref="InterPro:IPR023674" /db_xref="InterPro:IPR028364" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="SubtiList:BG10164" /db_xref="UniProtKB/Swiss-Prot:Q06797" /translation="MAKKGKKYVEAAKLVDRSKAYDVSEAVALVKKTNTAKFDATVEV AFRLGVDPRKNDQQIRGAVVLPNGTGKTQRVLVFAKGEKAKEAEAAGADFVGDTDYIN KIQQGWFDFDVIVATPDMMGEVGKIGRVLGPKGLMPNPKTGTVTFEVEKAIGEIKAGK VEYRVDKAGNIHVPIGKVSFEDEKLVENFTTMYDTILKAKPAAAKGVYVKNVAVTSTM GPGVKVDSSTFNVK*" /label="rplA CDS" gene 118702..119400 /gene="rplA" /locus_tag="BSU_01030" /old_locus_tag="BSU01030" /label="rplA gene" downshifts complement(119374) /Source="Nicolas_upshifts" /id="D42" /incds=0 /nref=3 /ntot=95 /MaxReadThrough="3.54108" /MaxDrop="3.36566" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U89" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA 119446..119586 /gene="ldlJ" /locus_tag="BSU_misc_RNA_3" /product="L10_leader" /experiment="publication(s) with functional evidences, PMID:26101249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26101249; Product type n: RNA" /label="ldlJ RNA" gene 119446..119586 /gene="ldlJ" /locus_tag="BSU_misc_RNA_3" /label="ldlJ gene" upshifts complement(119462) /Source="Nicolas_upshifts" /id="U89" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.603396603396603" /psig="0.248751248751249" /xcortree=60 /SigmaFactorBS="gctgtgataatatacacctcggtaggataattaagcggttag gcccctactgtCTACGgtataaatgatattctattttacaacattttgaataatatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(119465..119469) /Source="Nicolas_upshift_promotors" /id="U89" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.603396603396603" /psig="0.248751248751249" /xcortree=60 /SigmaFactorBS="gctgtgataatatacacctcggtaggataattaagcggttag gcccctactgtCTACGgtataaatgatattctattttacaacattttgaataatatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts 119518 /Source="Nicolas_upshifts" /id="D43" /incds=1 /nref=1 /ntot=19 /MaxReadThrough="9.14839" /MaxDrop="2.9211" /score="20.0562348" /energy="-13.2" /TU="U88" /idTUdmin="U84" /TUdmin=1497 /isTUend="FALSE" /label="downshifts" CDS 119652..120152 /gene="rplJ" /locus_tag="BSU_01040" /old_locus_tag="BSU01040" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9810686, 11341315, 12682299, 18247578, 26101249, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9810686, 11341315, 12682299, 18247578, 26101249, 22720735; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L10 (BL5)" /protein_id="NP_387985.2" /db_xref="EnsemblGenomes-Gn:BSU01040" /db_xref="EnsemblGenomes-Tr:CAB11880" /db_xref="GOA:P42923" /db_xref="InterPro:IPR001790" /db_xref="InterPro:IPR002363" /db_xref="InterPro:IPR022973" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11220" /db_xref="UniProtKB/Swiss-Prot:P42923" /translation="MSSAIETKKVVVEEIASKLKESKSTIIVDYRGLNVSEVTELRKQ LREANVEFKVYKNTMTRRAVEQAELNGLNDFLTGPNAIAFSTEDVVAPAKVLNDFAKN HEALEIKAGVIEGKVSTVEEVKALAELPSREGLLSMLLSVLQAPVRNLALAAKAVAEQ KEEQGA*" /label="rplJ CDS" gene 119652..120152 /gene="rplJ" /locus_tag="BSU_01040" /old_locus_tag="BSU01040" /label="rplJ gene" CDS 120198..120569 /gene="rplL" /locus_tag="BSU_01050" /old_locus_tag="BSU01050" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 6771249, 8755892, 26101249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 6771249, 8755892, 26101249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L12 (BL9)" /protein_id="NP_387986.1" /db_xref="EnsemblGenomes-Gn:BSU01050" /db_xref="EnsemblGenomes-Tr:CAB11881" /db_xref="GOA:P02394" /db_xref="InterPro:IPR000206" /db_xref="InterPro:IPR008932" /db_xref="InterPro:IPR013823" /db_xref="InterPro:IPR014719" /db_xref="InterPro:IPR036235" /db_xref="SubtiList:BG10726" /db_xref="UniProtKB/Swiss-Prot:P02394" /translation="MALNIEEIIASVKEATVLELNDLVKAIEEEFGVTAAAPVAVAGG AAAGGAAEEQSEFDLILAGAGSQKIKVIKVVREITGLGLKEAKELVDNTPKPLKEGIA KEEAEELKAKLEEVGASVEVK*" /label="rplL CDS" gene 120198..120569 /gene="rplL" /locus_tag="BSU_01050" /old_locus_tag="BSU01050" /label="rplL gene" downshifts 120485 /Source="Nicolas_upshifts" /id="D44" /incds=1 /nref=5 /ntot=149 /MaxReadThrough="8.89506" /MaxDrop="4.0945" /score="20.6066659" /energy="-11.7" /TU="U88" /idTUdmin="U84" /TUdmin=2464 /isTUend="FALSE" /label="downshifts" downshifts 120558 /Source="Nicolas_upshifts" /id="D45" /incds=0 /nref=25 /ntot=157 /MaxReadThrough="7.44654" /MaxDrop="4.0033" /score="20.6066659" /energy="-11.7" /TU="U88" /idTUdmin="U84" /TUdmin=2537 /isTUend="FALSE" /label="downshifts" CDS 120659..121264 /gene="rlmG" /locus_tag="BSU_01060" /old_locus_tag="BSU01060" /EC_number="2.1.1.174" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17010380; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m2G1835 methyltransferase" /protein_id="NP_387987.1" /db_xref="EnsemblGenomes-Gn:BSU01060" /db_xref="EnsemblGenomes-Tr:CAB11882" /db_xref="GOA:P37872" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10727" /db_xref="UniProtKB/Swiss-Prot:P37872" /translation="MSEHYYSEKPSVKSNKQTWSFRLRNKDFTFTSDSGVFSKKEVDF GSRLLIDSFEEPEVEGGILDVGCGYGPIGLSLASDFKDRTIHMIDVNERAVELSNENA EQNGITNVKIYQSDLFSNVDSAQTFASILTNPPIRAGKKVVHAIFEKSAEHLKASGEL WIVIQKKQGAPSAIEKLEELFDEVSVVQKKKGYYIIKAKKV*" /label="rlmG CDS" gene 120659..121264 /gene="rlmG" /locus_tag="BSU_01060" /old_locus_tag="BSU01060" /label="rlmG gene" promotor_-35 121259..121263 /Source="Nicolas_upshift_promotors" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" S_feature 121277..121509 /Source="Nicolas_S_feature" /locus_tag="new_121686_121918" /HighExp="G180, G150, H2O2, G135, Cold, T-5.40H, LoTm, T-3.40H, Oxctl, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S51" upshifts 121277 /Source="Nicolas_upshifts" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-10 121279..121298 /Source="Nicolas_upshift_promotors" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" CDS 121510..125091 /gene="rpoB" /locus_tag="BSU_01070" /old_locus_tag="BSU01070" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10049799, 10744988, 12455702, 12682299, 15060052, 28163698" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10049799, 10744988, 12455702, 12682299, 15060052, 28163698; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (beta subunit)" /protein_id="NP_387988.2" /db_xref="EnsemblGenomes-Gn:BSU01070" /db_xref="EnsemblGenomes-Tr:CAB11883" /db_xref="GOA:P37870" /db_xref="InterPro:IPR007120" /db_xref="InterPro:IPR007121" /db_xref="InterPro:IPR007641" /db_xref="InterPro:IPR007642" /db_xref="InterPro:IPR007644" /db_xref="InterPro:IPR007645" /db_xref="InterPro:IPR010243" /db_xref="InterPro:IPR015712" /db_xref="InterPro:IPR019462" /db_xref="PDB:2LY7" /db_xref="SubtiList:BG10728" /db_xref="UniProtKB/Swiss-Prot:P37870" /translation="MTGQLVQYGRHRQRRSYARISEVLELPNLIEIQTSSYQWFLDEG LREMFQDISPIEDFTGNLSLEFIDYSLGEPKYPVEESKERDVTYSAPLRVKVRLINKE TGEVKDQDVFMGDFPIMTDTGTFIINGAERVIVSQLVRSPSVYFSGKVDKNGKKGFTA TVIPNRGAWLEYETDAKDVVYVRIDRTRKLPVTVLLRALGFGSDQEILDLIGENEYLR NTLDKDNTENSDKALLEIYERLRPGEPPTVENAKSLLDSRFFDPKRYDLANVGRYKIN KKLHIKNRLFNQRLAETLVDPETGEILAEKGQILDRRTLDKVLPYLENGIGFRKLYPN GGVVEDEVTLQSIKIFAPTDQEGEQVINVIGNAYIEEEIKNITPADIISSISYFFNLL HGVGDTDDIDHLGNRRLRSVGELLQNQFRIGLSRMERVVRERMSIQDTNTITPQQLIN IRPVIASIKEFFGSSQLSQFMDQTNPLAELTHKRRLSALGPGGLTRERAGMEVRDVHY SHYGRMCPIETPEGPNIGLINSLSSYAKVNRFGFIETPYRRVDPETGKVTGRIDYLTA DEEDNYVVAQANARLDDEGAFIDDSIVARFRGENTVVSRNRVDYMDVSPKQVVSAATA CIPFLENDDSNRALMGANMQRQAVPLMQPEAPFVGTGMEYVSGKDSGAAVICKHPGIV ERVEAKNVWVRRYEEVDGQKVKGNLDKYSLLKFVRSNQGTCYNQRPIVSVGDEVVKGE ILADGPSMELGELALGRNVMVGFMTWDGYNYEDAIIMSERLVKDDVYTSIHIEEYESE ARDTKLGPEEITRDIPNVGEDALRNLDDRGIIRIGAEVKDGDLLVGKVTPKGVTELTA EERLLHAIFGEKAREVRDTSLRVPHGGGGIIHDVKVFNREDGDELPPGVNQLVRVYIV QKRKISEGDKMAGRHGNKGVISKILPEEDMPYLPDGTPIDIMLNPLGVPSRMNIGQVL ELHMGMAARYLGIHIASPVFDGAREEDVWETLEEAGMSRDAKTVLYDGRTGEPFDNRV SVGIMYMIKLAHMVDDKLHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGA AYTLQEILTVKSDDVVGRVKTYEAIVKGDNVPEPGVPESFKVLIKELQSLGMDVKILS GDEEEIEMRDLEDEEDAKQADGLALSGDEEPEETASADVERDVVTKE*" /label="rpoB CDS" gene 121510..125091 /gene="rpoB" /locus_tag="BSU_01070" /old_locus_tag="BSU01070" /label="rpoB gene" promotor_-10 complement(123095..123114) /Source="Nicolas_upshift_promotors" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(123098) /Source="Nicolas_upshifts" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(123128..123137) /Source="Nicolas_upshift_promotors" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(123966..123970) /Source="Nicolas_upshift_promotors" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(123971) /Source="Nicolas_upshifts" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(123985..123991) /Source="Nicolas_upshift_promotors" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 125153..128752 /gene="rpoC" /locus_tag="BSU_01080" /old_locus_tag="BSU01080" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10672039, 10675340, 10910724, 11029421, 9795209, 10438769, 23070162, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10672039, 10675340, 10910724, 11029421, 9795209, 10438769, 23070162, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (beta' subunit)" /protein_id="NP_387989.2" /db_xref="EnsemblGenomes-Gn:BSU01080" /db_xref="EnsemblGenomes-Tr:CAB11884" /db_xref="GOA:P37871" /db_xref="InterPro:IPR000722" /db_xref="InterPro:IPR006592" /db_xref="InterPro:IPR007066" /db_xref="InterPro:IPR007080" /db_xref="InterPro:IPR007081" /db_xref="InterPro:IPR007083" /db_xref="InterPro:IPR012754" /db_xref="SubtiList:BG10729" /db_xref="UniProtKB/Swiss-Prot:P37871" /translation="MLDVNNFEYMNIGLASPDKIRSWSFGEVKKPETINYRTLKPEKD GLFCERIFGPTKDWECHCGKYKRVRYKGVVCDRCGVEVTRAKVRRERMGHIELAAPVS HIWYFKGIPSRMGLVLDMSPRALEEVIYFASYVVTDPANTPLEKKQLLSEKEYRAYLD KYGNKFQASMGAEAIHKLLQDIDLVKEVDMLKEELKTSQGQRRTRAIKRLEVLEAFRN SGNKPSWMILDVLPVIPPELRPMVQLDGGRFATSDLNDLYRRVINRNNRLKRLLDLGA PSIIVQNEKRMLQEAVDALIDNGRRGRPVTGPGNRPLKSLSHMLKGKQGRFRQNLLGK RVDYSGRSVIVVGPHLKMYQCGLPKEMALELFKPFVMKELVEKGLAHNIKSAKRKIER VQPEVWDVLESVIKEHPVLLNRAPTLHRLGIQAFEPTLVEGRAIRLHPLVCTAYNADF DGDQMAVHVPLSAEAQAEARILMLAAQNILNPKDGKPVVTPSQDMVLGNYYLTLERAG AVGEGMVFKNTDEALLAYQNGYVHLHTRVAVAANSLKNVTFTEEQRSKLLITTVGKLV FNEILPESFPYMNEPTKSNIEEKTPDRFFLEKGADVKAVIAQQPINAPFKKGILGKII AEIFKRFHITETSKMLDRMKNLGFKYSTKAGITVGVSDIVVLDDKQEILEEAQSKVDN VMKQFRRGLITEEERYERVISIWSAAKDVIQGKLMKSLDELNPIYMMSDSGARGNASN FTQLAGMRGLMANPAGRIIELPIKSSFREGLTVLEYFISTHGARKGLADTALKTADSG YLTRRLVDVAQDVIIRETDCGTDRGILAKPLKEGTETIERLEERLIGRFARKQVKHPE TGEVLVNENELIDEDKALEIVEAGIEEVWIRSAFTCNTPHGVCKRCYGRNLATGSDVE VGEAVGIIAAQSIGEPGTQLTMRTFHTGGVAGDDITQGLPRIQELFEARNPKGQATIT EIDGTVVEINEVRDKQQEIVVQGAVETRSYTAPYNSRLKVAEGDKITRGQVLTEGSID PKELLKVTDLTTVQEYLLHEVQKVYRMQGVEIGDKHVEVMVRQMLRKVRVIDAGDTDV LPGTLLDIHQFTEANKKVLLEGNRPATGRPVLLGITKASLETDSFLSAASFQETTRVL TDAAIKGKRDELLGLKENVIIGKLVPAGTGMMKYRKVKPVSNVQPTDDMVPVE*" /label="rpoC CDS" gene 125153..128752 /gene="rpoC" /locus_tag="BSU_01080" /old_locus_tag="BSU01080" /label="rpoC gene" downshifts complement(128217) /Source="Nicolas_upshifts" /id="D46" /incds=1 /nref=1 /ntot=76 /MaxReadThrough="3.40002" /MaxDrop="2.38911" /score="-2.05539956" /energy="-7.5" /TU="U93" /idTUdmin="U93" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" upshifts complement(128371) /Source="Nicolas_upshifts" /id="U93" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.952047952047952" /psig="0.000999000999001" /xcortree=64 /SigmaFactorBS="caatgtacctggaagcacatcagtgtcaccggcatcaatcaC Gcgtactttgcgaagcatctggcgaaccattacttctacgtgtttatcaccgatttca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(128389..128390) /Source="Nicolas_upshift_promotors" /id="U93" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.952047952047952" /psig="0.000999000999001" /xcortree=64 /SigmaFactorBS="caatgtacctggaagcacatcagtgtcaccggcatcaatcaC Gcgtactttgcgaagcatctggcgaaccattacttctacgtgtttatcaccgatttca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(128701) /Source="Nicolas_upshifts" /id="D47" /incds=0 /nref=98 /ntot=210 /MaxReadThrough="1.61828" /MaxDrop="4.90549" /score="-2.05539956" /energy="-7.5" /TU="NA" /idTUdmin="U95" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 128753..128874 /Source="Nicolas_S_feature" /locus_tag="new_129162_129283" /HighExp="LoTm, HiOs, S3, SMMPr, Heat, S1, BC, Glu, S4, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S52" promotor_-35 128856..128863 /Source="Nicolas_upshift_promotors" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" upshifts 128876 /Source="Nicolas_upshifts" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-10 128877..128896 /Source="Nicolas_upshift_promotors" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" misc_feature complement(128894..128898) /Source="Nicolas_upshift_promotors" /id="U95" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.909090909090909" /psig="0.023976023976024" /xcortree=67 /SigmaFactorBS="ggcctgtgatactttatcataagacataaacatatcctccaa agtaacaggtttatttcGAGCAccttggttatattatcattctaggagacgaatgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(128897) /Source="Nicolas_upshifts" /id="U95" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.909090909090909" /psig="0.023976023976024" /xcortree=67 /SigmaFactorBS="ggcctgtgatactttatcataagacataaacatatcctccaa agtaacaggtttatttcGAGCAccttggttatattatcattctaggagacgaatgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 128931..129179 /gene="rulS" /locus_tag="BSU_01090" /old_locus_tag="BSU01090" /function="16.8: Protect" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11574053, 11948165, 17468242, 7657605, 22355167, 23249744, 24204571, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574053, 11948165, 17468242, 7657605, 22355167, 23249744, 24204571, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="K-turn RNA binding protein; alternative ribosomal protein L7A" /protein_id="NP_387990.1" /db_xref="EnsemblGenomes-Gn:BSU01090" /db_xref="EnsemblGenomes-Tr:CAB11885" /db_xref="GOA:P46350" /db_xref="InterPro:IPR000948" /db_xref="InterPro:IPR004038" /db_xref="InterPro:IPR023460" /db_xref="InterPro:IPR029064" /db_xref="PDB:3V7E" /db_xref="PDB:4LCK" /db_xref="PDB:4TZP" /db_xref="PDB:4TZV" /db_xref="PDB:4TZW" /db_xref="PDB:4TZZ" /db_xref="SubtiList:BG11365" /db_xref="UniProtKB/Swiss-Prot:P46350" /translation="MSYDKVSQAKSIIIGTKQTVKALKRGSVKEVVVAKDADPILTSS VVSLAEDQGISVSMVESMKKLGKACGIEVGAAAVAIIL*" /label="rulS CDS" gene 128931..129179 /gene="rulS" /locus_tag="BSU_01090" /old_locus_tag="BSU01090" /label="rulS gene" S_feature 129180..129292 /Source="Nicolas_S_feature" /locus_tag="new_129589_129701" /HighExp="T-3.40H, M/G, T-1.40H, T-5.40H, Salt, Mal, T-0.40H, G/S, M9-exp, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S53" CDS 129293..129709 /gene="rpsL" /locus_tag="BSU_01100" /old_locus_tag="BSU01100" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11489846, 12682299, 16484214, 18252828, 19383706, 20007320" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489846, 12682299, 16484214, 18252828, 19383706, 20007320; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S12 (BS12)" /protein_id="NP_387991.2" /db_xref="EnsemblGenomes-Gn:BSU01100" /db_xref="EnsemblGenomes-Tr:CAB11886" /db_xref="GOA:P21472" /db_xref="InterPro:IPR005679" /db_xref="InterPro:IPR006032" /db_xref="InterPro:IPR012340" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19009" /db_xref="UniProtKB/Swiss-Prot:P21472" /translation="MPTINQLIRKGRVSKVENSKSPALNKGYNSFKKEHTNVSSPQKR GVCTRVGTMTPKKPNSALRKYARVRLTNGIEVTAYIPGIGHNLQEHSVVLIRGGRVKD LPGVRYHIVRGALDTAGVENRAQGRSKYGTKKPKAK*" /label="rpsL CDS" gene 129293..129709 /gene="rpsL" /locus_tag="BSU_01100" /old_locus_tag="BSU01100" /label="rpsL gene" CDS 129751..130221 /gene="rpsG" /locus_tag="BSU_01110" /old_locus_tag="BSU01110" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 12682299, 19653700" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 12682299, 19653700; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S7 (BS7)" /protein_id="NP_387992.2" /db_xref="EnsemblGenomes-Gn:BSU01110" /db_xref="EnsemblGenomes-Tr:CAB11887" /db_xref="GOA:P21469" /db_xref="InterPro:IPR000235" /db_xref="InterPro:IPR005717" /db_xref="InterPro:IPR020606" /db_xref="InterPro:IPR023798" /db_xref="InterPro:IPR036823" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19006" /db_xref="UniProtKB/Swiss-Prot:P21469" /translation="MPRKGPVAKRDVLPDPIYNSKLVSRLINKMMIDGKKGKSQTILY KSFDIIKERTGNDAMEVFEQALKNIMPVLEVKARRVGGANYQVPVEVRPERRTTLGLR WLVNYARLRGEKTMEERLANEILDAANNTGAAVKKREDTHKMAEANKAFAHYRW*" /label="rpsG CDS" gene 129751..130221 /gene="rpsG" /locus_tag="BSU_01110" /old_locus_tag="BSU01110" /label="rpsG gene" CDS 130275..132353 /gene="fusA" /locus_tag="BSU_01120" /old_locus_tag="BSU01120" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:815236, 815243, 1556067, 4629789, 19366171, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 815236, 815243, 1556067, 4629789, 19366171, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="elongation factor G" /protein_id="NP_387993.2" /db_xref="EnsemblGenomes-Gn:BSU01120" /db_xref="EnsemblGenomes-Tr:CAB11888" /db_xref="GOA:P80868" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR004540" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR005517" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR009022" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035649" /db_xref="PDB:5VH6" /db_xref="SubtiList:BG11939" /db_xref="UniProtKB/Swiss-Prot:P80868" /translation="MAREFSLEKTRNIGIMAHIDAGKTTTTERILFYTGRIHKIGETH EGASQMDWMEQEQERGITITSAATTAQWKGYRVNIIDTPGHVDFTVEVERSLRVLDGA VAVLDAQSGVEPQTETVWRQATTYGVPRIVFVNKMDKIGADFLYSVGTLRDRLQANAH AIQLPIGAEDNFEGIIDLVENVAYFYEDDLGTRSDAKEIPEEYKEQAEELRNSLIEAV CELDEELMDKYLEGEEITIDELKAGIRKGTLNVEFYPVLVGSAFKNKGVQLVLDAVLD YLPAPTDVAAIKGTRPDTNEEIERHSSDEEPFSALAFKVMTDPYVGKLTFFRVYSGTL DSGSYVKNSTKGKRERVGRILQMHANSREEISTVYAGDIAAAVGLKDTTTGDTLCDEK DLVILESMEFPEPVIDVAIEPKSKADQDKMGIALAKLAEEDPTFRTQTNPETGQTIIS GMGELHLDIIVDRMKREFKVEANVGAPQVAYRETFRTGAKVEGKFVRQSGGRGQFGHV WIEFEPNEEGAGFEFENAIVGGVVPREYIPAVQAGLEDALENGVLAGFPLIDIKAKLF DGSYHDVDSNEMAFKVAASMALKNAVSKCNPVLLEPIMKVEVVIPEEYMGDIMGDITS RRGRVEGMEARGNAQVVRAMVPLAEMFGYATALRSNTQGRGTFTMHMDHYEEVPKSVA EEIIKKNKGE*" /label="fusA CDS" gene 130275..132353 /gene="fusA" /locus_tag="BSU_01120" /old_locus_tag="BSU01120" /label="fusA gene" S_feature 132354..132472 /Source="Nicolas_S_feature" /locus_tag="new_132763_132881" /HighExp="T-5.40H, T-4.40H, UNK1, SMM, HiTm, T-3.40H, T-2.40H, SMMPr, MG 90, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S54" CDS 132473..133663 /gene="tufA" /locus_tag="BSU_01130" /old_locus_tag="BSU01130" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10774755, 12682299, 7706132, 20133608, 22938038, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10774755, 12682299, 7706132, 20133608, 22938038, 22720735; Product type f : factor" /codon_start=1 /transl_table=11 /product="elongation factor Tu" /protein_id="NP_387994.1" /db_xref="EnsemblGenomes-Gn:BSU01130" /db_xref="EnsemblGenomes-Tr:CAB11889" /db_xref="GOA:P33166" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004160" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR004541" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR009001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR033720" /db_xref="SubtiList:BG11056" /db_xref="UniProtKB/Swiss-Prot:P33166" /translation="MAKEKFDRSKSHANIGTIGHVDHGKTTLTAAITTVLHKKSGKGT AMAYDQIDGAPEERERGITISTAHVEYETETRHYAHVDCPGHADYVKNMITGAAQMDG AILVVSAADGPMPQTREHILLSKNVGVPYIVVFLNKCDMVDDEELLELVEMEVRDLLS EYDFPGDDVPVVKGSALKALEGDAEWEAKIFELMDAVDEYIPTPERDTEKPFMMPVED VFSITGRGTVATGRVERGQVKVGDEVEIIGLQEENKKTTVTGVEMFRKLLDYAEAGDN IGALLRGVSREEIQRGQVLAKPGTITPHSKFKAEVYVLSKEEGGRHTPFFSNYRPQFY FRTTDVTGIIHLPEGVEMVMPGDNTEMNVELISTIAIEEGTRFSIREGGRTVGSGVVS TITE*" /label="tufA CDS" gene 132473..133663 /gene="tufA" /locus_tag="BSU_01130" /old_locus_tag="BSU01130" /label="tufA gene" downshifts 133658 /Source="Nicolas_upshifts" /id="D48" /incds=0 /nref=258 /ntot=269 /MaxReadThrough="4.84568" /MaxDrop="8.56168" /score="39.3984056" /energy="-12.9" /TU="U88,U90,U94" /idTUdmin="U88" /TUdmin="-1081" /isTUend="FALSE" /label="downshifts" misc_feature complement(133689..133692) /Source="Nicolas_upshift_promotors" /id="U96" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.917082917082917" /psig="0.001998001998002" /xcortree=68 /SigmaFactorBS="acccctcgaatatgatagatcctattatacaagaaaaagata agcaaacaaaaaacgagacCCACaggggtctcgtttaaaaccatactattactcagtg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(133693) /Source="Nicolas_upshifts" /id="U96" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.917082917082917" /psig="0.001998001998002" /xcortree=68 /SigmaFactorBS="acccctcgaatatgatagatcctattatacaagaaaaagata agcaaacaaaaaacgagacCCACaggggtctcgtttaaaaccatactattactcagtg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 133719..133738 /Source="Nicolas_upshift_promotors" /id="U97" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=1878 /SigmaFactorBS="tatggttttaaacgagacccctgtgggtctcgttttttgttt gcttatctttTTCTTGTATAATAGGATCTAtcatattcgaggggttaatatttatgat t" /listShort="ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 133727 /Source="Nicolas_upshifts" /id="U97" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=1878 /SigmaFactorBS="tatggttttaaacgagacccctgtgggtctcgttttttgttt gcttatctttTTCTTGTATAATAGGATCTAtcatattcgaggggttaatatttatgat t" /listShort="ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 133762..134718 /gene="ybaC" /locus_tag="BSU_01140" /old_locus_tag="BSU01140" /EC_number="3.4.11.5" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative proline iminopeptidase" /protein_id="NP_387995.2" /db_xref="EnsemblGenomes-Gn:BSU01140" /db_xref="EnsemblGenomes-Tr:CAB11890" /db_xref="GOA:P70981" /db_xref="InterPro:IPR002410" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11988" /db_xref="UniProtKB/Swiss-Prot:P70981" /translation="MIPEKKSIAIMKELSIGNTKQMLMINGVDVKNPLLLFLHGGPGT PQIGYVRHYQKELEQYFTVVHWDQRGSGLSYSKRISHHSMTINHFIKDTIQVTQWLLA HFSKSKLYLAGHSWGSILALHVLQQRPDLFYTYYGISQVVNPQDEESTAYQHIREISE SKKASILSFLTRFIGAPPWKQDIQHLIYRFCVELTRGGFTHRHRQSLAVLFQMLTGNE YGVRNMHSFLNGLRFSKKHLTDELYRFNAFTSVPSIKVPCVFISGKHDLIVPAEISKQ YYQELEAPEKRWFQFENSAHTPHIEEPSLFANTLSRHARHHL*" /label="ybaC CDS" gene 133762..134718 /gene="ybaC" /locus_tag="BSU_01140" /old_locus_tag="BSU01140" /label="ybaC gene" promotor_-35 134725..134732 /Source="Nicolas_upshift_promotors" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 134746..134765 /Source="Nicolas_upshift_promotors" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 134761..134954 /Source="Nicolas_S_feature" /locus_tag="new_135170_135363" /HighExp="T-1.40H, T-2.40H, T-1.10H, SMM, T-3.40H, T-4.40H, BI, BMM, H2O2, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S55" upshifts 134761 /Source="Nicolas_upshifts" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" CDS 134955..135263 /gene="rpsJ" /locus_tag="BSU_01150" /old_locus_tag="BSU01150" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 27964882" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 27964882; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S10 (BS13); transcription antitermination factor" /protein_id="NP_387996.1" /db_xref="EnsemblGenomes-Gn:BSU01150" /db_xref="EnsemblGenomes-Tr:CAB11891" /db_xref="GOA:P21471" /db_xref="InterPro:IPR001848" /db_xref="InterPro:IPR018268" /db_xref="InterPro:IPR027486" /db_xref="InterPro:IPR036838" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19008" /db_xref="UniProtKB/Swiss-Prot:P21471" /translation="MAKQKIRIRLKAYDHRILDQSAEKIVETAKRSGASVSGPIPLPT EKSVYTILRAVHKYKDSREQFEMRTHKRLIDIVNPTPQTVDALMRLDLPSGVDIEIKL *" /label="rpsJ CDS" gene 134955..135263 /gene="rpsJ" /locus_tag="BSU_01150" /old_locus_tag="BSU01150" /label="rpsJ gene" CDS 135303..135932 /gene="rplC" /locus_tag="BSU_01160" /old_locus_tag="BSU01160" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17981968, 19154332, 23759864" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17981968, 19154332, 23759864; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L3 (BL3)" /protein_id="NP_387997.1" /db_xref="EnsemblGenomes-Gn:BSU01160" /db_xref="EnsemblGenomes-Tr:CAB11892" /db_xref="GOA:P42920" /db_xref="InterPro:IPR000597" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR019926" /db_xref="InterPro:IPR019927" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11218" /db_xref="UniProtKB/Swiss-Prot:P42920" /translation="MTKGILGRKIGMTQVFAENGDLIPVTVIEAAPNVVLQKKTAEND GYEAIQLGFDDKREKLSNKPEKGHVAKAETAPKRFVKELRGVEMDAYEVGQEVKVEIF SAGEIVDVTGVSKGKGFQGAIKRHGQSRGPMSHGSRYHRRPGSMGPVDPNRVFKGKLL PGRMGGEQITVQNLEIVKVDAERNLLLIKGNVPGAKKSLITVKSAVKSK*" /label="rplC CDS" gene 135303..135932 /gene="rplC" /locus_tag="BSU_01160" /old_locus_tag="BSU01160" /label="rplC gene" CDS 135960..136583 /gene="rplD" /locus_tag="BSU_01170" /old_locus_tag="BSU01170" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10898684, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L4" /protein_id="NP_387998.1" /db_xref="EnsemblGenomes-Gn:BSU01170" /db_xref="EnsemblGenomes-Tr:CAB11893" /db_xref="GOA:P42921" /db_xref="InterPro:IPR002136" /db_xref="InterPro:IPR013005" /db_xref="InterPro:IPR023574" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11219" /db_xref="UniProtKB/Swiss-Prot:P42921" /translation="MPKVALYNQNGSTAGDIELNASVFGIEPNESVVFDAILMQRASL RQGTHKVKNRSEVRGGGRKPWRQKGTGRARQGSIRSPQWRGGGVVFGPTPRSYSYKLP KKVRRLAIKSVLSSKVIDNNIIVLEDLTLDTAKTKEMAAILKGLSVEKKALIVTADAN EAVALSARNIPGVTVVEANGINVLDVVNHEKLLITKAAVEKVEEVLA*" /label="rplD CDS" gene 135960..136583 /gene="rplD" /locus_tag="BSU_01170" /old_locus_tag="BSU01170" /label="rplD gene" CDS 136583..136870 /gene="rplW" /locus_tag="BSU_01180" /old_locus_tag="BSU01180" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17981968, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17981968, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L23" /protein_id="NP_387999.2" /db_xref="EnsemblGenomes-Gn:BSU01180" /db_xref="EnsemblGenomes-Tr:CAB11894" /db_xref="GOA:P42924" /db_xref="InterPro:IPR001014" /db_xref="InterPro:IPR012678" /db_xref="InterPro:IPR013025" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11221" /db_xref="UniProtKB/Swiss-Prot:P42924" /translation="MKDPRDVLKRPVITERSADLMTEKKYTFEVDVRANKTEVKDAVE SIFGVKVDKVNIMNYKGKSKRVGRYTGMTSRRRKAIVKLTADSKEIEIFEA*" /label="rplW CDS" gene 136583..136870 /gene="rplW" /locus_tag="BSU_01180" /old_locus_tag="BSU01180" /label="rplW gene" CDS 136902..137735 /gene="rplB" /locus_tag="BSU_01190" /old_locus_tag="BSU01190" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 23249812, 24637032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 23249812, 24637032; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L2 (BL2)" /protein_id="NP_388000.2" /db_xref="EnsemblGenomes-Gn:BSU01190" /db_xref="EnsemblGenomes-Tr:CAB11895" /db_xref="GOA:P42919" /db_xref="InterPro:IPR002171" /db_xref="InterPro:IPR005880" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR014726" /db_xref="InterPro:IPR022666" /db_xref="InterPro:IPR022669" /db_xref="InterPro:IPR022671" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11217" /db_xref="UniProtKB/Swiss-Prot:P42919" /translation="MAIKKYKPTSNGRRGMTTSDFAEITTDKPEKSLLAPLHKKGGRN NQGKLTVRHQGGGHKRQYRVIDFKRDKDGIPGRVATVEYDPNRSANIALINYADGEKR YILAPKGIQVGTEIMSGPEADIKVGNALPLINIPVGTVVHNIELKPGKGGQLVRSAGT SAQVLGKEGKYVLVRLNSGEVRMILSACRASIGQVGNEQHELINIGKAGRSRWKGIRP TVRGSVMNPNDHPHGGGEGRAPIGRKSPMSPWGKPTLGFKTRKKKNKSDKFIVRRRKN K*" /label="rplB CDS" gene 136902..137735 /gene="rplB" /locus_tag="BSU_01190" /old_locus_tag="BSU01190" /label="rplB gene" downshifts complement(137038) /Source="Nicolas_upshifts" /id="D49" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="3.39972" /MaxDrop="4.09052" /score="-4.16840603" /energy="-12.8" /TU="NA" /idTUdmin="U99" /TUdmin=1342 /isTUend="FALSE" /label="downshifts" CDS 137793..138071 /gene="rpsS" /locus_tag="BSU_01200" /old_locus_tag="BSU01200" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S19 (BS19)" /protein_id="NP_388001.1" /db_xref="EnsemblGenomes-Gn:BSU01200" /db_xref="EnsemblGenomes-Tr:CAB11896" /db_xref="GOA:P21476" /db_xref="InterPro:IPR002222" /db_xref="InterPro:IPR005732" /db_xref="InterPro:IPR020934" /db_xref="InterPro:IPR023575" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19011" /db_xref="UniProtKB/Swiss-Prot:P21476" /translation="MARSLKKGPFVDGHLMTKIEKLNETDKKQVVKTWSRRSTIFPQF IGHTIAVYDGRKHVPVFISEDMVGHKLGEFAPTRTYKGHASDDKKTRR*" /label="rpsS CDS" gene 137793..138071 /gene="rpsS" /locus_tag="BSU_01200" /old_locus_tag="BSU01200" /label="rpsS gene" CDS 138088..138429 /gene="rplV" /locus_tag="BSU_01210" /old_locus_tag="BSU01210" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7928988, 12682299, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7928988, 12682299, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L22 (BL17)" /protein_id="NP_388002.1" /db_xref="EnsemblGenomes-Gn:BSU01210" /db_xref="EnsemblGenomes-Tr:CAB11897" /db_xref="GOA:P42060" /db_xref="InterPro:IPR001063" /db_xref="InterPro:IPR005727" /db_xref="InterPro:IPR018260" /db_xref="InterPro:IPR036394" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11078" /db_xref="UniProtKB/Swiss-Prot:P42060" /translation="MQAKAVARTVRIAPRKARLVMDLIRGKQVGEAVSILNLTPRAAS PIIEKVLKSAIANAEHNYEMDANNLVISQAFVDEGPTLKRFRPRAMGRASQINKRTSH ITIVVSEKKEG*" /label="rplV CDS" gene 138088..138429 /gene="rplV" /locus_tag="BSU_01210" /old_locus_tag="BSU01210" /label="rplV gene" CDS 138433..139089 /gene="rpsC" /locus_tag="BSU_01220" /old_locus_tag="BSU01220" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S3 (BS3)" /protein_id="NP_388003.2" /db_xref="EnsemblGenomes-Gn:BSU01220" /db_xref="EnsemblGenomes-Tr:CAB11898" /db_xref="GOA:P21465" /db_xref="InterPro:IPR001351" /db_xref="InterPro:IPR004044" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR005704" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR018280" /db_xref="InterPro:IPR036419" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19005" /db_xref="UniProtKB/Swiss-Prot:P21465" /translation="MGQKVNPVGLRIGVIRDWESKWYAGKDYADFLHEDLKIREYISK RLSDASVSKVEIERAANRVNITIHTAKPGMVIGKGGSEVEALRKALNSLTGKRVHINI LEIKRADLDAQLVADNIARQLENRVSFRRAQKQQIQRTMRAGAQGVKTMVSGRLGGAD IARSEYYSEGTVPLHTLRADIDYATSEADTTYGKLGVKVWIYRGEVLPTKKKNEEGGK *" /label="rpsC CDS" gene 138433..139089 /gene="rpsC" /locus_tag="BSU_01220" /old_locus_tag="BSU01220" /label="rpsC gene" downshifts complement(138446) /Source="Nicolas_upshifts" /id="D50" /incds=0 /nref=1 /ntot=62 /MaxReadThrough="3.68388" /MaxDrop="2.1922" /score="-4.16840603" /energy="-12.8" /TU="U99" /idTUdmin="U99" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(138527..138531) /Source="Nicolas_upshift_promotors" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(138534) /Source="Nicolas_upshifts" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(138548..138550) /Source="Nicolas_upshift_promotors" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 139091..139525 /gene="rplP" /locus_tag="BSU_01230" /old_locus_tag="BSU01230" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16390447, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16390447, 24335279; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L16" /protein_id="NP_388004.1" /db_xref="EnsemblGenomes-Gn:BSU01230" /db_xref="EnsemblGenomes-Tr:CAB11899" /db_xref="GOA:P14577" /db_xref="InterPro:IPR000114" /db_xref="InterPro:IPR016180" /db_xref="InterPro:IPR020798" /db_xref="InterPro:IPR036920" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10755" /db_xref="UniProtKB/Swiss-Prot:P14577" /translation="MLLPKRVKYRREHRGKMRGRAKGGTEVHFGEFGIQALEASWITN RQIEAARIAMTRYMKRGGKVWIKIFPSKPYTAKPLEVRMGSGKGAPEGWVAVVKPGKV LFEISGVSEEVAREALRLASHKLPIKTKFVKREEIGGESNES*" /label="rplP CDS" gene 139091..139525 /gene="rplP" /locus_tag="BSU_01230" /old_locus_tag="BSU01230" /label="rplP gene" CDS 139515..139715 /gene="rpmC" /locus_tag="BSU_01240" /old_locus_tag="BSU01240" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L29" /protein_id="NP_388005.1" /db_xref="EnsemblGenomes-Gn:BSU01240" /db_xref="EnsemblGenomes-Tr:CAB11900" /db_xref="GOA:P12873" /db_xref="InterPro:IPR001854" /db_xref="InterPro:IPR018254" /db_xref="InterPro:IPR036049" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10756" /db_xref="UniProtKB/Swiss-Prot:P12873" /translation="MKANEIRDLTTAEIEQKVKSLKEELFNLRFQLATGQLENTARIR EVRKAIARMKTVIREREIAANK*" /label="rpmC CDS" gene 139515..139715 /gene="rpmC" /locus_tag="BSU_01240" /old_locus_tag="BSU01240" /label="rpmC gene" CDS 139738..140001 /gene="rpsQ" /locus_tag="BSU_01250" /old_locus_tag="BSU01250" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S17 (BS16)" /protein_id="NP_388006.1" /db_xref="EnsemblGenomes-Gn:BSU01250" /db_xref="EnsemblGenomes-Tr:CAB11901" /db_xref="GOA:P12874" /db_xref="InterPro:IPR000266" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019979" /db_xref="InterPro:IPR019984" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10757" /db_xref="UniProtKB/Swiss-Prot:P12874" /translation="MSERNQRKVYQGRVVSDKMDKTITVVVETYKKHTLYGKRVKYSK KFKAHDENNQAKIGDIVKIMETRPLSATKRFRLVEVVEEAVII*" /label="rpsQ CDS" gene 139738..140001 /gene="rpsQ" /locus_tag="BSU_01250" /old_locus_tag="BSU01250" /label="rpsQ gene" CDS 140042..140410 /gene="rplNA" /locus_tag="BSU_01260" /old_locus_tag="BSU01260" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 8805509, 12682299, 22829778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 8805509, 12682299, 22829778; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L14" /protein_id="NP_388007.1" /db_xref="EnsemblGenomes-Gn:BSU01260" /db_xref="EnsemblGenomes-Tr:CAB11902" /db_xref="GOA:P12875" /db_xref="InterPro:IPR000218" /db_xref="InterPro:IPR005745" /db_xref="InterPro:IPR019972" /db_xref="InterPro:IPR036853" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10758" /db_xref="UniProtKB/Swiss-Prot:P12875" /translation="MIQQETRLKVADNSGAREVLTIKVLGGSGRKTANIGDVIVCTVK QATPGGVVKKGEVVKAVIVRTKSGARRSDGSYISFDENACVIIRDDKSPRGTRIFGPV ARELRENNFMKIVSLAPEVI*" /label="rplNA CDS" gene 140042..140410 /gene="rplNA" /locus_tag="BSU_01260" /old_locus_tag="BSU01260" /label="rplNA gene" CDS 140448..140759 /gene="rplX" /locus_tag="BSU_01270" /old_locus_tag="BSU01270" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11278078, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11278078, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L24 (BL23)" /protein_id="NP_388008.1" /db_xref="EnsemblGenomes-Gn:BSU01270" /db_xref="EnsemblGenomes-Tr:CAB11903" /db_xref="GOA:P0CI78" /db_xref="InterPro:IPR003256" /db_xref="InterPro:IPR005824" /db_xref="InterPro:IPR005825" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR014722" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10759" /db_xref="UniProtKB/Swiss-Prot:P0CI78" /translation="MHVKKGDKVMVISGKDKGKQGTILAAFPKKDRVLVEGVNMVKKH SKPTQANPQGGISNQEAPIHVSNVMPLDPKTGEVTRVGYKVEDGKKVRVAKKSGQVLD K*" /label="rplX CDS" gene 140448..140759 /gene="rplX" /locus_tag="BSU_01270" /old_locus_tag="BSU01270" /label="rplX gene" CDS 140786..141325 /gene="rplE" /locus_tag="BSU_01280" /old_locus_tag="BSU01280" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L5 (BL6)" /protein_id="NP_388009.1" /db_xref="EnsemblGenomes-Gn:BSU01280" /db_xref="EnsemblGenomes-Tr:CAB11904" /db_xref="GOA:P12877" /db_xref="InterPro:IPR002132" /db_xref="InterPro:IPR020929" /db_xref="InterPro:IPR020930" /db_xref="InterPro:IPR022803" /db_xref="InterPro:IPR031309" /db_xref="InterPro:IPR031310" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10760" /db_xref="UniProtKB/Swiss-Prot:P12877" /translation="MNRLKEKYNKEIAPALMTKFNYDSVMQVPKIEKIVINMGVGDAV QNAKAIDSAVEELTFIAGQKPVVTRAKKSIAGFRLREGMPIGAKVTLRGERMYDFLDK LISVSLPRVRDFRGVSKKSFDGRGNYTLGIKEQLIFPEIDYDKVTKVRGMDIVIVTTA NTDEEARELLTQVGMPFQK*" /label="rplE CDS" gene 140786..141325 /gene="rplE" /locus_tag="BSU_01280" /old_locus_tag="BSU01280" /label="rplE gene" CDS 141348..141533 /gene="rpsNA" /locus_tag="BSU_01290" /old_locus_tag="BSU01290" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17163968, 19648245, 20208344, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17163968, 19648245, 20208344, 27561249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S14" /protein_id="NP_388010.1" /db_xref="EnsemblGenomes-Gn:BSU01290" /db_xref="EnsemblGenomes-Tr:CAB11905" /db_xref="GOA:P12878" /db_xref="InterPro:IPR001209" /db_xref="InterPro:IPR018271" /db_xref="InterPro:IPR023053" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10761" /db_xref="UniProtKB/Swiss-Prot:P12878" /translation="MAKKSMIAKQQRTPKFKVQEYTRCERCGRPHSVIRKFKLCRICF RELAYKGQIPGVKKASW*" /label="rpsNA CDS" gene 141348..141533 /gene="rpsNA" /locus_tag="BSU_01290" /old_locus_tag="BSU01290" /label="rpsNA gene" CDS 141565..141963 /gene="rpsH" /locus_tag="BSU_01300" /old_locus_tag="BSU01300" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S8 (BS8)" /protein_id="NP_388011.2" /db_xref="EnsemblGenomes-Gn:BSU01300" /db_xref="EnsemblGenomes-Tr:CAB11906" /db_xref="GOA:P12879" /db_xref="InterPro:IPR000630" /db_xref="InterPro:IPR035987" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10762" /db_xref="UniProtKB/Swiss-Prot:P12879" /translation="MVMTDPIADMLTRIRNANMVRHEKLEIPASKLKREIAEILKREG FIRDVEFVEDSKQGIIRVFLKYGQNNERVITGLKRISKPGLRVYAKSNEVPRVLNGLG IAIISTSQGVLTDKEARAKQAGGEVLAYVW*" /label="rpsH CDS" gene 141565..141963 /gene="rpsH" /locus_tag="BSU_01300" /old_locus_tag="BSU01300" /label="rpsH gene" downshifts complement(141966) /Source="Nicolas_upshifts" /id="D51" /incds=0 /nref=1 /ntot=74 /MaxReadThrough="2.68318" /MaxDrop="2.55712" /score="5.40276403" /energy="-15.9" /TU="NA" /idTUdmin="U99" /TUdmin="-3586" /isTUend="FALSE" /label="downshifts" CDS 141993..142532 /gene="rplF" /locus_tag="BSU_01310" /old_locus_tag="BSU01310" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 25330043; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L6 (BL8)" /protein_id="NP_388012.1" /db_xref="EnsemblGenomes-Gn:BSU01310" /db_xref="EnsemblGenomes-Tr:CAB11907" /db_xref="GOA:P46898" /db_xref="InterPro:IPR000702" /db_xref="InterPro:IPR002358" /db_xref="InterPro:IPR019906" /db_xref="InterPro:IPR020040" /db_xref="InterPro:IPR036789" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11408" /db_xref="UniProtKB/Swiss-Prot:P46898" /translation="MSRVGKKLLEIPSDVTVTLNDNNTVAVKGPKGELTRTFHPDMEI KVEDNVLTVARPSDQKEHRALHGTTRSLLGNMVEGVSKGFERGLELVGVGYRASKSGN KLVLNVGYSHPVEIVPEEGIEIEVPSQTKVVVKGTDKERVGAIAANIRAVRSPEPYKG KGIRYEGEVVRRKEGKSAK*" /label="rplF CDS" gene 141993..142532 /gene="rplF" /locus_tag="BSU_01310" /old_locus_tag="BSU01310" /label="rplF gene" CDS 142565..142927 /gene="rplR" /locus_tag="BSU_01320" /old_locus_tag="BSU01320" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L18" /protein_id="NP_388013.2" /db_xref="EnsemblGenomes-Gn:BSU01320" /db_xref="EnsemblGenomes-Tr:CAB11908" /db_xref="GOA:P46899" /db_xref="InterPro:IPR004389" /db_xref="InterPro:IPR005484" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11409" /db_xref="UniProtKB/Swiss-Prot:P46899" /translation="MITKTSKNAARLKRHARVRAKLSGTAERPRLNVFRSNKHIYAQI IDDVNGVTLASASTLDKDLNVESTGDTSAATKVGELVAKRAAEKGISDVVFDRGGYLY HGRVKALADAAREAGLKF*" /label="rplR CDS" gene 142565..142927 /gene="rplR" /locus_tag="BSU_01320" /old_locus_tag="BSU01320" /label="rplR gene" CDS 142952..143452 /gene="rpsE" /locus_tag="BSU_01330" /old_locus_tag="BSU01330" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6211592, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6211592, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S5" /protein_id="NP_388014.1" /db_xref="EnsemblGenomes-Gn:BSU01330" /db_xref="EnsemblGenomes-Tr:CAB11909" /db_xref="GOA:P21467" /db_xref="InterPro:IPR000851" /db_xref="InterPro:IPR005324" /db_xref="InterPro:IPR005712" /db_xref="InterPro:IPR013810" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018192" /db_xref="InterPro:IPR020568" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10442" /db_xref="UniProtKB/Swiss-Prot:P21467" /translation="MRRIDPSKLELEERLVTVNRVAKVVKGGRRFRFAALVVVGDKNG HVGFGTGKAQEVPEAIRKAVEDAKKNLIEVPMVGTTIPHEIIGRFGAGNILLKPASEG TGVIAGGPVRAVLELAGVADILSKSLGSNTPINMIRATLQGLSELKRAEDVAKLRGKS VEELLG*" /label="rpsE CDS" gene 142952..143452 /gene="rpsE" /locus_tag="BSU_01330" /old_locus_tag="BSU01330" /label="rpsE gene" CDS 143466..143645 /gene="rpmD" /locus_tag="BSU_01340" /old_locus_tag="BSU01340" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L30 (BL27)" /protein_id="NP_388015.1" /db_xref="EnsemblGenomes-Gn:BSU01340" /db_xref="EnsemblGenomes-Tr:CAB11910" /db_xref="GOA:P19947" /db_xref="InterPro:IPR005996" /db_xref="InterPro:IPR016082" /db_xref="InterPro:IPR018038" /db_xref="InterPro:IPR036919" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10443" /db_xref="UniProtKB/Swiss-Prot:P19947" /translation="MAKLEITLKRSVIGRPEDQRVTVRTLGLKKTNQTVVHEDNAAIR GMINKVSHLVSVKEQ*" /label="rpmD CDS" gene 143466..143645 /gene="rpmD" /locus_tag="BSU_01340" /old_locus_tag="BSU01340" /label="rpmD gene" CDS 143676..144116 /gene="rplO" /locus_tag="BSU_01350" /old_locus_tag="BSU01350" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15855514, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15855514, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L15" /protein_id="NP_388016.1" /db_xref="EnsemblGenomes-Gn:BSU01350" /db_xref="EnsemblGenomes-Tr:CAB11911" /db_xref="GOA:P19946" /db_xref="InterPro:IPR001196" /db_xref="InterPro:IPR005749" /db_xref="InterPro:IPR021131" /db_xref="InterPro:IPR030878" /db_xref="InterPro:IPR036227" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10444" /db_xref="UniProtKB/Swiss-Prot:P19946" /translation="MKLHELKPSEGSRKTRNRVGRGIGSGNGKTAGKGHKGQNARSGG GVRPGFEGGQMPLFQRLPKRGFTNINRKEYAVVNLDKLNGFAEGTEVTPELLLETGVI SKLNAGVKILGNGKLEKKLTVKANKFSASAKEAVEAAGGTAEVI*" /label="rplO CDS" gene 143676..144116 /gene="rplO" /locus_tag="BSU_01350" /old_locus_tag="BSU01350" /label="rplO gene" CDS 144118..145413 /gene="secY" /locus_tag="BSU_01360" /old_locus_tag="BSU01360" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9917412, 15341641, 15849754, 16850406, 23852076, 22720735, 27336478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9917412, 15341641, 15849754, 16850406, 23852076, 22720735, 27336478; Product type t: transporter" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_388017.1" /db_xref="EnsemblGenomes-Gn:BSU01360" /db_xref="EnsemblGenomes-Tr:CAB11912" /db_xref="GOA:P16336" /db_xref="InterPro:IPR002208" /db_xref="InterPro:IPR023201" /db_xref="InterPro:IPR026593" /db_xref="InterPro:IPR030659" /db_xref="SubtiList:BG10445" /db_xref="UniProtKB/Swiss-Prot:P16336" /translation="MFKTISNFMRVSDIRNKIIFTLLMLIVFRIGAFIPVPYVNAEAL QAQSQMGVFDLLNTFGGGALYQFSIFAMGITPYITASIIIQLLQMDVVPKFTEWSKQG EVGRRKLAQFTRYFTIVLGFIQALGMSYGFNNLANGMLIEKSGVSTYLIIALVLTGGT AFLMWLGEQITSHGVGNGISIIIFAGIVSSIPKTIGQIYETQFVGSNDQLFIHIVKVA LLVIAILAVIVGVIFIQQAVRKIAIQYAKGTGRSPAGGGQSTHLPLKVNPAGVIPVIF AVAFLITPRTIASFFGTNDVTKWIQNNFDNTHPVGMAIYVALIIAFTYFYAFVQVNPE QMADNLKKQGGYIPGVRPGKMTQDRITSILYRLTFVGSIFLAVISILPIFFIQFAGLP QSAQIGGTSLLIVVGVALETMKQLESQLVKRNYRGFMKN*" /label="secY CDS" gene 144118..145413 /gene="secY" /locus_tag="BSU_01360" /old_locus_tag="BSU01360" /label="secY gene" CDS 145468..146121 /gene="adk" /locus_tag="BSU_01370" /old_locus_tag="BSU01370" /EC_number="2.7.4.3" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:8061005, 8288548, 9056261, 9715904, 11106368, 16452168" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8061005, 8288548, 9056261, 9715904, 11106368, 16452168; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="adenylate kinase" /protein_id="NP_388018.1" /db_xref="EnsemblGenomes-Gn:BSU01370" /db_xref="EnsemblGenomes-Tr:CAB11913" /db_xref="GOA:P16304" /db_xref="InterPro:IPR000850" /db_xref="InterPro:IPR006259" /db_xref="InterPro:IPR007862" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033690" /db_xref="PDB:1P3J" /db_xref="PDB:2EU8" /db_xref="PDB:2OO7" /db_xref="PDB:2ORI" /db_xref="PDB:2OSB" /db_xref="PDB:2P3S" /db_xref="PDB:2QAJ" /db_xref="PDB:3DKV" /db_xref="PDB:3DL0" /db_xref="PDB:4MKF" /db_xref="PDB:4MKG" /db_xref="PDB:4MKH" /db_xref="PDB:4QBF" /db_xref="PDB:4QBG" /db_xref="PDB:4TYP" /db_xref="PDB:4TYQ" /db_xref="SubtiList:BG10446" /db_xref="UniProtKB/Swiss-Prot:P16304" /translation="MNLVLMGLPGAGKGTQGERIVEDYGIPHISTGDMFRAAMKEETP LGLEAKSYIDKGELVPDEVTIGIVKERLGKDDCERGFLLDGFPRTVAQAEALEEILEE YGKPIDYVINIEVDKDVLMERLTGRRICSVCGTTYHLVFNPPKTPGICDKDGGELYQR ADDNEETVSKRLEVNMKQTQPLLDFYSEKGYLANVNGQQDIQDVYADVKDLLGGLKK* " /label="adk CDS" gene 145468..146121 /gene="adk" /locus_tag="BSU_01370" /old_locus_tag="BSU01370" /label="adk gene" CDS 146118..146864 /gene="mapA" /locus_tag="BSU_01380" /old_locus_tag="BSU01380" /EC_number="3.4.11.18" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16207374, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine aminopeptidase" /protein_id="NP_388019.1" /db_xref="EnsemblGenomes-Gn:BSU01380" /db_xref="EnsemblGenomes-Tr:CAB11914" /db_xref="GOA:P19994" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR002467" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG10447" /db_xref="UniProtKB/Swiss-Prot:P19994" /translation="MIICKTPRELGIMREAGRIVALTHEELKKHIKPGISTKELDQIA ERFIKKQGAIPSFKGYNGFRGSICVSVNEELVHGIPGSRVLKDGDIISIDIGAKLNGY HGDSAWTYPVGNISDDDKKLLEVTEESLYKGLQEAKPGERLSNISHAIQTYVENEQFS VVREYVGHGVGQDLHEDPQIPHYGPPNKGPRLKPGMVLAIEPMVNAGSRYVKTLADNW TVVTVDGKKCAHFEHTIAITETGFDILTRV*" /label="mapA CDS" gene 146118..146864 /gene="mapA" /locus_tag="BSU_01380" /old_locus_tag="BSU01380" /label="mapA gene" CDS 146903..147127 /gene="ybzG" /locus_tag="BSU_01389" /old_locus_tag="BSU01389" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17157877; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative ribosome binding protein" /protein_id="YP_003097669.1" /db_xref="EnsemblGenomes-Gn:BSU01389" /db_xref="EnsemblGenomes-Tr:CAX52539" /db_xref="UniProtKB/Swiss-Prot:C0H3S8" /translation="MIGQKAWVNIGKTEFILLLVVGILTIINVLTADGEKRTFHSPKK KNINHLTLYDCVSPEVQNSINETGRVTNFF*" /label="ybzG CDS" gene 146903..147127 /gene="ybzG" /locus_tag="BSU_01389" /old_locus_tag="BSU01389" /label="ybzG gene" CDS 147176..147394 /gene="infA" /locus_tag="BSU_01390" /old_locus_tag="BSU01390" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9868784, 20477873, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-I" /protein_id="NP_388020.1" /db_xref="EnsemblGenomes-Gn:BSU01390" /db_xref="EnsemblGenomes-Tr:CAB11915" /db_xref="GOA:P20458" /db_xref="InterPro:IPR004368" /db_xref="InterPro:IPR006196" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG11043" /db_xref="UniProtKB/Swiss-Prot:P20458" /translation="MAKDDVIEVEGTIVETLPNAMFKVELENGHTVLAHVSGKIRMHF IRILPGDKVTVELSPYDLTRGRITYRYK*" /label="infA CDS" gene 147176..147394 /gene="infA" /locus_tag="BSU_01390" /old_locus_tag="BSU01390" /label="infA gene" CDS 147428..147541 /gene="rpmJ" /locus_tag="BSU_01400" /old_locus_tag="BSU01400" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1783905, 23002217, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1783905, 23002217, 24335279; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L36 (ribosomal protein B)" /protein_id="NP_388021.1" /db_xref="EnsemblGenomes-Gn:BSU01400" /db_xref="EnsemblGenomes-Tr:CAB11916" /db_xref="GOA:P20278" /db_xref="InterPro:IPR000473" /db_xref="InterPro:IPR035977" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11042" /db_xref="UniProtKB/Swiss-Prot:P20278" /translation="MKVRPSVKPICEKCKVIRRKGKVMVICENPKHKQKQG*" /label="rpmJ CDS" gene 147428..147541 /gene="rpmJ" /locus_tag="BSU_01400" /old_locus_tag="BSU01400" /label="rpmJ gene" CDS 147564..147929 /gene="rpsM" /locus_tag="BSU_01410" /old_locus_tag="BSU01410" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S13" /protein_id="NP_388022.2" /db_xref="EnsemblGenomes-Gn:BSU01410" /db_xref="EnsemblGenomes-Tr:CAB11917" /db_xref="GOA:P20282" /db_xref="InterPro:IPR001892" /db_xref="InterPro:IPR010979" /db_xref="InterPro:IPR018269" /db_xref="InterPro:IPR019980" /db_xref="InterPro:IPR027437" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10730" /db_xref="UniProtKB/Swiss-Prot:P20282" /translation="MARIAGVDIPRDKRVVISLTYIFGIGRTTAQQVLKEAGVSEDTR VRDLTEEELGKIRDIIDKLKVEGDLRREVSLNIKRLIEIGSYRGIRHRRGLPVRGQNS KNNARTRKGPRRTVANKKK*" /label="rpsM CDS" gene 147564..147929 /gene="rpsM" /locus_tag="BSU_01410" /old_locus_tag="BSU01410" /label="rpsM gene" CDS 147950..148345 /gene="rpsK" /locus_tag="BSU_01420" /old_locus_tag="BSU01420" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10217780, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217780, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S11 (BS11)" /protein_id="NP_388023.1" /db_xref="EnsemblGenomes-Gn:BSU01420" /db_xref="EnsemblGenomes-Tr:CAB11918" /db_xref="GOA:P04969" /db_xref="InterPro:IPR001971" /db_xref="InterPro:IPR018102" /db_xref="InterPro:IPR019981" /db_xref="InterPro:IPR036967" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10731" /db_xref="UniProtKB/Swiss-Prot:P04969" /translation="MAAARKSNTRKRRVKKNIESGIAHIRSTFNNTIVTITDTHGNAI SWSSAGALGFRGSRKSTPFAAQMAAETAAKGSIEHGLKTLEVTVKGPGSGREAAIRAL QAAGLEVTAIRDVTPVPHNGCRPPKRRRV*" /label="rpsK CDS" gene 147950..148345 /gene="rpsK" /locus_tag="BSU_01420" /old_locus_tag="BSU01420" /label="rpsK gene" S_feature 148346..148521 /Source="Nicolas_S_feature" /locus_tag="new_148755_148930" /HighExp="G135, dia5, Lbexp, S0, aero, dia0, T-4.40H, G150, Paraq, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S56" CDS 148522..149466 /gene="rpoA" /locus_tag="BSU_01430" /old_locus_tag="BSU01430" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1484484, 6811591, 9594570, 10972808, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1484484, 6811591, 9594570, 10972808, 12682299, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (alpha subunit)" /protein_id="NP_388024.1" /db_xref="EnsemblGenomes-Gn:BSU01430" /db_xref="EnsemblGenomes-Tr:CAB11919" /db_xref="GOA:P20429" /db_xref="InterPro:IPR011260" /db_xref="InterPro:IPR011262" /db_xref="InterPro:IPR011263" /db_xref="InterPro:IPR011773" /db_xref="InterPro:IPR036603" /db_xref="InterPro:IPR036643" /db_xref="PDB:1Z3E" /db_xref="PDB:3GFK" /db_xref="PDB:3IHQ" /db_xref="SubtiList:BG10732" /db_xref="UniProtKB/Swiss-Prot:P20429" /translation="MIEIEKPKIETVEISDDAKFGKFVVEPLERGYGTTLGNSLRRIL LSSLPGAAVTSIQIDGVLHEFSTIEGVVEDVTTIILHIKKLALKIYSDEEKTLEIDVQ GEGTVTAADITHDSDVEILNPDLHIATLGENASFRVRLTAQRGRGYTPADANKRDDQP IGVIPIDSIYTPVSRVSYQVENTRVGQVANYDKLTLDVWTDGSTGPKEAIALGSKILT EHLNIFVGLTDEAQHAEIMVEKEEDQKEKVLEMTIEELDLSVRSYNCLKRAGINTVQE LANKTEEDMMKVRNLGRKSLEEVKAKLEELGLGLRKDD*" /label="rpoA CDS" gene 148522..149466 /gene="rpoA" /locus_tag="BSU_01430" /old_locus_tag="BSU01430" /label="rpoA gene" CDS 149544..149906 /gene="rplQ" /locus_tag="BSU_01440" /old_locus_tag="BSU01440" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6801428, 10717392, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6801428, 10717392, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L17 (BL15)" /protein_id="NP_388025.1" /db_xref="EnsemblGenomes-Gn:BSU01440" /db_xref="EnsemblGenomes-Tr:CAB11920" /db_xref="GOA:P20277" /db_xref="InterPro:IPR000456" /db_xref="InterPro:IPR036373" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11041" /db_xref="UniProtKB/Swiss-Prot:P20277" /translation="MSYRKLGRTSAQRKAMLRDLTTDLIINERIETTETRAKELRSVV EKMITLGKRGDLHARRQAAAYIRNEVANEENNQDALQKLFSDIATRYEERQGGYTRIM KLGPRRGDGAPMAIIELV*" /label="rplQ CDS" gene 149544..149906 /gene="rplQ" /locus_tag="BSU_01440" /old_locus_tag="BSU01440" /label="rplQ gene" downshifts 149908 /Source="Nicolas_upshifts" /id="D52" /incds=0 /nref=171 /ntot=259 /MaxReadThrough="7.50771" /MaxDrop="5.4374" /score="2.32634618" /energy="-10.5" /TU="U98" /idTUdmin="U98" /TUdmin="-5577" /isTUend="FALSE" /label="downshifts" S_feature 149953..150033 /Source="Nicolas_S_feature" /locus_tag="new_150362_150442" /HighExp="Cold, G180, G135, G150, H2O2, S0, C30, Oxctl, Paraq, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S57" CDS 150034..150879 /gene="ecfA" /locus_tag="BSU_01450" /old_locus_tag="BSU01450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12110480, 21135102, 26052893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="energizing coupling factor of ABC influx transporter (ATP-binding protein)" /protein_id="NP_388026.2" /db_xref="EnsemblGenomes-Gn:BSU01450" /db_xref="EnsemblGenomes-Tr:CAB11921" /db_xref="GOA:P40735" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015856" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030947" /db_xref="SubtiList:BG11067" /db_xref="UniProtKB/Swiss-Prot:P40735" /translation="MNQNQLISVEDIVFRYRKDAERRALDGVSLQVYEGEWLAIVGHN GSGKSTLARALNGLILPESGDIEVAGIQLTEESVWEVRKKIGMVFQNPDNQFVGTTVR DDVAFGLENNGVPREEMIERVDWAVKQVNMQDFLDQEPHHLSGGQKQRVAIAGVIAAR PDIIILDEATSMLDPIGREEVLETVRHLKEQGMATVISITHDLNEAAKADRIIVMNGG KKYAEGPPEEIFKLNKELVRIGLDLPFSFQLSQLLRENGLALEENHLTQEGLVKELWT LQSKM*" /label="ecfA CDS" gene 150034..150879 /gene="ecfA" /locus_tag="BSU_01450" /old_locus_tag="BSU01450" /label="ecfA gene" CDS 150894..151724 /gene="ecfAB" /locus_tag="BSU_01460" /old_locus_tag="BSU01460" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12110480, 21135102, 26052893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12110480, 21135102, 26052893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="energizing coupling factor of ABC influx transporter (ATP-binding protein)" /protein_id="NP_388027.1" /db_xref="EnsemblGenomes-Gn:BSU01460" /db_xref="EnsemblGenomes-Tr:CAB11922" /db_xref="GOA:P70970" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015856" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030946" /db_xref="SubtiList:BG11989" /db_xref="UniProtKB/Swiss-Prot:P70970" /translation="MKTPFERLALYDINASIKEGSYVAVIGHTGSGKSTLLQHLNGLL KPTKGQISLGSTVIQAGKKNKDLKKLRKKVGIVFQFPEHQLFEETVLKDISFGPMNFG VKKEDAEQKAREMLQLVGLSEELLDRSPFELSGGQMRRVAIAGVLAMDPEVLVLDEPT AGLDPRGRKEIMDMFYELHQRGNLTTILVTHSMEDAAAYADEMIVMHKGTIQASGSPR DLFLKGEEMAGWGLDLPETIKFQRHLEAALGVRFNEPMLTIEDAAAEIRALFQGEKTL *" /label="ecfAB CDS" gene 150894..151724 /gene="ecfAB" /locus_tag="BSU_01460" /old_locus_tag="BSU01460" /label="ecfAB gene" CDS 151721..152518 /gene="ecfT" /locus_tag="BSU_01470" /old_locus_tag="BSU01470" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 18931129, 21135102, 26052893; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the influx ECF transporters" /protein_id="NP_388028.2" /db_xref="EnsemblGenomes-Gn:BSU01470" /db_xref="EnsemblGenomes-Tr:CAB11923" /db_xref="GOA:P70972" /db_xref="InterPro:IPR003339" /db_xref="InterPro:IPR024919" /db_xref="SubtiList:BG11990" /db_xref="UniProtKB/Swiss-Prot:P70972" /translation="MMDSMIIGKYVPGTSLVHRLDPRTKLITIFLFVCIVFLANNVQT YALLGLFTIGVVSLTRVPFSFLMKGLKPIIWIVLFTFLLHILMTHEGPIIFQIGFFKV YEGGLVQGIFISLRFVYLILITTLLTLTTTPIEITDGMEQLLNPLKKLKLPVHELALM MSISLRFIPTLMEETDKIMKAQMARGVDFTSGPVKERVKAIVPLLVPLFVSAFKRAEE LAVAMEARGYQGGEGRTKYRKLVWTGKDTSVIVSLIVLAALLFFLRA*" /label="ecfT CDS" gene 151721..152518 /gene="ecfT" /locus_tag="BSU_01470" /old_locus_tag="BSU01470" /label="ecfT gene" CDS 152528..153271 /gene="truA" /locus_tag="BSU_01480" /old_locus_tag="BSU01480" /EC_number="5.4.99.12" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10529181, 15353568, 17114947, 17466622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA pseudouridine (38-40) synthase" /protein_id="NP_388029.2" /db_xref="EnsemblGenomes-Gn:BSU01480" /db_xref="EnsemblGenomes-Tr:CAB11924" /db_xref="GOA:P70973" /db_xref="InterPro:IPR001406" /db_xref="InterPro:IPR020095" /db_xref="InterPro:IPR020097" /db_xref="InterPro:IPR020103" /db_xref="SubtiList:BG11992" /db_xref="UniProtKB/Swiss-Prot:P70973" /translation="MRLKCTISYDGHLFNGYQVQPGKRTVQDELEKALAVLHKSKDRI PVVSSGRTDSGVHAAGQVIHFDTPLSIPAERWPYALNALLPDDIAVKQAEIADDGFHA RFSAVKKEYRYFVYTEKHPDVFKRHYAYHFSYRLNVQDMREAAKHLIGTHDFTSFCAA KTEVQDKVRTIYELDWTETADGLQMRITGSGFLYNMVRIIAGTLLDAGIGKISPDEVK SMLEAKDREAAGRTAPGHGLYLWNVYYDN*" /label="truA CDS" gene 152528..153271 /gene="truA" /locus_tag="BSU_01480" /old_locus_tag="BSU01480" /label="truA gene" S_feature complement(152630..153098) /Source="Nicolas_S_feature" /locus_tag="new_153039_153507_c" /HighExp="S6, S8, S7, C30, G135, BT, S5, C90, M/G, Pyr" /AntisenseName="truA" /AntisenseCor="-0.30232258010971202" /AntisenseRegPval="-6.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S58" promotor_-35 152763..152768 /Source="Nicolas_upshift_promotors" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 152783..152800 /Source="Nicolas_upshift_promotors" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 152802 /Source="Nicolas_upshifts" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(153098..153117) /Source="Nicolas_upshift_promotors" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(153120) /Source="Nicolas_upshifts" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(153130..153139) /Source="Nicolas_upshift_promotors" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 153291..153297 /Source="Nicolas_upshift_promotors" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 153312..153331 /Source="Nicolas_upshift_promotors" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 153316 /Source="Nicolas_upshifts" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 153328..153384 /gene="ldlM" /locus_tag="BSU_misc_RNA_4" /product="putative L13_leader" /note="Evidence 3: Putative function from multiple computational evidences; Product type n: RNA" /label="ldlM RNA" gene 153328..153384 /gene="ldlM" /locus_tag="BSU_misc_RNA_4" /label="ldlM gene" CDS 153433..153870 /gene="rplM" /locus_tag="BSU_01490" /old_locus_tag="BSU01490" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10781545, 12682299, 23504016, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10781545, 12682299, 23504016, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L13" /protein_id="NP_388030.2" /db_xref="EnsemblGenomes-Gn:BSU01490" /db_xref="EnsemblGenomes-Tr:CAB11925" /db_xref="GOA:P70974" /db_xref="InterPro:IPR005822" /db_xref="InterPro:IPR005823" /db_xref="InterPro:IPR023563" /db_xref="InterPro:IPR036899" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11970" /db_xref="UniProtKB/Swiss-Prot:P70974" /translation="MRTTPMANASTIERKWLVVDAAGKTLGRLSSEVAAILRGKHKPT YTPHVDTGDHVIIINAEKIELTGKKLTDKIYYRHTQHPGGLKSRTALEMRTNYPEKML ELAIKGMLPKGSLGRQMFKKLNVYRGSEHPHEAQKPEVYELRG*" /label="rplM CDS" gene 153433..153870 /gene="rplM" /locus_tag="BSU_01490" /old_locus_tag="BSU01490" /label="rplM gene" CDS 153891..154283 /gene="rpsI" /locus_tag="BSU_01500" /old_locus_tag="BSU01500" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 19653700, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S9" /protein_id="NP_388031.1" /db_xref="EnsemblGenomes-Gn:BSU01500" /db_xref="EnsemblGenomes-Tr:CAB11926" /db_xref="GOA:P21470" /db_xref="InterPro:IPR000754" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020574" /db_xref="InterPro:IPR023035" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19007" /db_xref="UniProtKB/Swiss-Prot:P21470" /translation="MAQVQYYGTGRRKSSVARVRLVPGEGRIVVNNREISEHIPSAAL IEDIKQPLTLTETAGTYDVLVNVHGGGLSGQAGAIRHGIARALLEADPEYRTTLKRAG LLTRDARMKERKKYGLKGARRAPQFSKR*" /label="rpsI CDS" gene 153891..154283 /gene="rpsI" /locus_tag="BSU_01500" /old_locus_tag="BSU01500" /label="rpsI gene" downshifts 154258 /Source="Nicolas_upshifts" /id="D53" /incds=0 /nref=262 /ntot=282 /MaxReadThrough="4.65387" /MaxDrop="8.11906" /score="30.5093496" /energy="-13.3" /TU="U98,U100,U102" /idTUdmin="U98" /TUdmin="-1227" /isTUend="FALSE" /label="downshifts" promotor_-35 154400..154407 /Source="Nicolas_upshift_promotors" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 154421..154440 /Source="Nicolas_upshift_promotors" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 154429..154710 /Source="Nicolas_S_feature" /locus_tag="new_154838_155119" /HighExp="H2O2, G180, G135, Paraq, Diami, dia15, Oxctl, Cold, Heat, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-, SigA" /TUshortPSig="0.999, 1, 0.479, 1" /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S59" upshifts 154429 /Source="Nicolas_upshifts" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" misc_feature 154709..154728 /Source="Nicolas_upshift_promotors" /id="U104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.804195804195804" /xcortree=3216 /SigmaFactorBS="gtttttatgaacttttttctaaatatgcaaagggaaagcgat atcaatctagaaataTTTGTTATACTCTATACATTaaagtaaggagaagattcatgaa t" /listShort="ybaJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 154712 /Source="Nicolas_upshifts" /id="U104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.804195804195804" /xcortree=3216 /SigmaFactorBS="gtttttatgaacttttttctaaatatgcaaagggaaagcgat atcaatctagaaataTTTGTTATACTCTATACATTaaagtaaggagaagattcatgaa t" /listShort="ybaJ" /GFF_Attribute="listLong" /label="upshifts" CDS 154747..155514 /gene="ybaJ" /locus_tag="BSU_01510" /old_locus_tag="BSU01510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26582911; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_388032.2" /db_xref="EnsemblGenomes-Gn:BSU01510" /db_xref="EnsemblGenomes-Tr:CAB11927" /db_xref="GOA:P70976" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11994" /db_xref="UniProtKB/Swiss-Prot:P70976" /translation="MNALVAHNSKAWDKKVETGNEWTVAVEQQVIEQAKKGNWDIRVT PMKDVPKDWFPPIKGLKVLCLASGGGQQGPVLAAAGADVTVLDNSEKQLNQDRMIAER DGLTIHTVKGSMDDLSVFNDESFDVIVHPVANVFVENVLPVWKEAYRVLKRNGILISG FVNPVVFLFDTELEQQGVLKVKHSIPYADPEDLPKHKVKKLIENNEALEFGHSLEDQI KGQIDAGFIVTGFYEDKGGFVLDQYIHTYSATRSVKV*" /label="ybaJ CDS" gene 154747..155514 /gene="ybaJ" /locus_tag="BSU_01510" /old_locus_tag="BSU01510" /label="ybaJ gene" downshifts 155505 /Source="Nicolas_upshifts" /id="D54" /incds=0 /nref=215 /ntot=251 /MaxReadThrough="2.69346" /MaxDrop="6.09641" /score="4.42269359" /energy="-10.3" /TU="NA" /idTUdmin="U100" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 155644..155650 /Source="Nicolas_upshift_promotors" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 155665..155676 /Source="Nicolas_upshift_promotors" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 155672 /Source="Nicolas_upshifts" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="upshifts" CDS 155700..156143 /gene="ybaK" /locus_tag="BSU_01520" /old_locus_tag="BSU01520" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14679227, 16267290" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388033.1" /db_xref="EnsemblGenomes-Gn:BSU01520" /db_xref="EnsemblGenomes-Tr:CAB11928" /db_xref="GOA:P50862" /db_xref="InterPro:IPR019667" /db_xref="SubtiList:BG11503" /db_xref="UniProtKB/Swiss-Prot:P50862" /translation="MAEVLSFMDVKRQKDFELEKNLLKELSLRQIIQSVKDCLEPLFP FLHDERDIITEGCIDFAIEAYLLGGRFGIFGYYGESMQSISARSAREEEELRMEFFDY LYNWIHEQYATFDKNTVYEAARKFIKDWWTAGFVQREKQCKLRMR*" /label="ybaK CDS" gene 155700..156143 /gene="ybaK" /locus_tag="BSU_01520" /old_locus_tag="BSU01520" /label="ybaK gene" promotor_-35 156143..156148 /Source="Nicolas_upshift_promotors" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 156164..156182 /Source="Nicolas_upshift_promotors" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 156165 /Source="Nicolas_upshifts" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="upshifts" CDS 156203..156916 /gene="cwlD" /locus_tag="BSU_01530" /old_locus_tag="BSU01530" /EC_number="3.5.1.28" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_388034.1" /db_xref="EnsemblGenomes-Gn:BSU01530" /db_xref="EnsemblGenomes-Tr:CAB11929" /db_xref="GOA:P50864" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR014234" /db_xref="SubtiList:BG11514" /db_xref="UniProtKB/Swiss-Prot:P50864" /translation="MRKKLKWLSFLLGFIILLFLFKYQFSNNDSWKPWSLPLSGKIIY LDPGHGGPDGGAVGGKLLEKDVTLEVAFRVRDYLQEQGALVIMTRESDTDLAPEGTKG YSRRKAEDLRQRVKLINHSEAELYISIHLNAIPSQKWSGAQSFYYGKYAENEKVAKYI QDELRRNLENTTRKAKRIHGIYLMQNVTKPGALIEVGFLSNPSEATLLGKPKYQDKVA SSIYKGILRYFTEKGDPPE*" /label="cwlD CDS" gene 156203..156916 /gene="cwlD" /locus_tag="BSU_01530" /old_locus_tag="BSU01530" /label="cwlD gene" upshifts 156961 /Source="Nicolas_upshifts" /id="U107" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=3187 /SigmaFactorBS="agaccctccggagtaatggagggttttcttgtggttctaagc ataagacacccgccatttatgTATGATATAATAATAATTGTaaacgaatacacaaaag g" /listShort="salA, S61, kbaA, S63, S64, rrnI-16S" /GFF_Attribute="listLong" /label="upshifts" misc_feature 156964..156983 /Source="Nicolas_upshift_promotors" /id="U107" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=3187 /SigmaFactorBS="agaccctccggagtaatggagggttttcttgtggttctaagc ataagacacccgccatttatgTATGATATAATAATAATTGTaaacgaatacacaaaag g" /listShort="salA, S61, kbaA, S63, S64, rrnI-16S" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 157012..158070 /gene="salA" /locus_tag="BSU_01540" /old_locus_tag="BSU01540" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11790741, 15126467, 26094643" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11790741, 15126467, 26094643; Product type r: regulator" /codon_start=1 /transl_table=11 /product="phosphorylation-dependent (Y327) transcriptionalregulator" /protein_id="NP_388035.1" /db_xref="EnsemblGenomes-Gn:BSU01540" /db_xref="EnsemblGenomes-Tr:CAB11930" /db_xref="GOA:P50863" /db_xref="InterPro:IPR000808" /db_xref="InterPro:IPR019591" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033756" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG11494" /db_xref="UniProtKB/Swiss-Prot:P50863" /translation="MIREDEVRKLVGEMREPFLQRPLGELDAVKEIKIKPEKRHISVK VALAKTGTAEQMQIQQEIVNVLKGAGAETVGLRFEELPEETVAKFRAPSAEKKTLLNM DNPPVFLAVASGKGGVGKSTVSVNLAISLARLGKKVGLIDADIYGFSVPDMMGITVRP TIEGEKLLPVERFGVKVMSMGFFVEENAPVVWRGPMLGKMLNNFFHEVEWGEVDYIVL DLPPGTGDVALDVHTMLPSCKEIIVSTPHPTAAFVAARAGSMAIKTDHEVVGVIENMA YYESAKTGEREYVFGKGGGDKLAEELNVPLLGRIPLKQPDWDKDQFAPSVYDENHPIG EIYQDIAKKIDAKMSVQV*" /label="salA CDS" gene 157012..158070 /gene="salA" /locus_tag="BSU_01540" /old_locus_tag="BSU01540" /label="salA gene" S_feature complement(157641..158105) /Source="Nicolas_S_feature" /locus_tag="new_158050_158514_c" /HighExp="S8, S7, S6, S5, C30, S4, C90, nit, ferm, Gly" /AntisenseName="salA" /AntisenseCor="-0.104183954485248" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S60" downshifts 158056 /Source="Nicolas_upshifts" /id="D55" /incds=0 /nref=29 /ntot=155 /MaxReadThrough="5.44939" /MaxDrop="4.18382" /score="-4.46878413" /energy="-9.1" /TU="U107" /idTUdmin="U106" /TUdmin=1185 /isTUend="FALSE" /label="downshifts" S_feature 158101..158772 /Source="Nicolas_S_feature" /locus_tag="new_158510_159181" /HighExp="Lbtran, H2O2, Cold, Lbstat, dia5, M40t45, M0t90, M40t90, T0.30H, S1" /AntisenseName="gerD" /AntisenseCor="-0.24235509346425901" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S61" CDS complement(158106..158663) /gene="gerD" /locus_tag="BSU_01550" /old_locus_tag="BSU01550" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17122337, 10618233, 10376819, 24530795" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17122337, 10618233, 10376819, 24530795; Product type f: factor" /codon_start=1 /transl_table=11 /product="lipoprotein factor mediating clustering of germination proteins" /protein_id="NP_388036.1" /db_xref="EnsemblGenomes-Gn:BSU01550" /db_xref="EnsemblGenomes-Tr:CAB11931" /db_xref="GOA:P16450" /db_xref="SubtiList:BG10644" /db_xref="UniProtKB/Swiss-Prot:P16450" /translation="MSKAKTLLMSCFLLLSVTACAPKDQAADMDYDQTKKMVVDILKT DDGKKAIKELLNDDAMNEALVIDQDAIKGTIEKTLTSKKGEEFWKNIFEDTDFAEGFA KTLQTEHEKVIKKLMKDPDYQKMLMSVMQDPGMDKKYSQLAKSQEFRSYLEEVINETL SSPLYKKQFEDELKKAAKDTAKESE*" /label="gerD CDS" gene complement(158106..158663) /gene="gerD" /locus_tag="BSU_01550" /old_locus_tag="BSU01550" /label="gerD gene" promotor_-10 complement(158695..158706) /Source="Nicolas_upshift_promotors" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(158707) /Source="Nicolas_upshifts" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(158720..158726) /Source="Nicolas_upshift_promotors" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(158740..159369) /Source="Nicolas_S_feature" /locus_tag="new_159149_159778_c" /HighExp="S3, T5.0H, S4, S8, M9-stat, T4.0H, T3.30H, S7, T3.0H, S6" /AntisenseName="kbaA" /AntisenseCor="7.9344921760152495E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S62" CDS 158773..159369 /gene="kbaA" /locus_tag="BSU_01560" /old_locus_tag="BSU01560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8576055, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8576055, 15849754, 16850406; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inner membrane protein involved in activation ofthe KinB signaling pathway to sporulation" /protein_id="NP_388037.1" /db_xref="EnsemblGenomes-Gn:BSU01560" /db_xref="EnsemblGenomes-Tr:CAB11932" /db_xref="GOA:P16449" /db_xref="InterPro:IPR024164" /db_xref="SubtiList:BG10643" /db_xref="UniProtKB/Swiss-Prot:P16449" /translation="MKSRGLVRFFFSILAVGALITSIVGFALKWGEYRGLFLTFEAGQ IFSVLFWFIGVGMIFSVISQMGFFVFLTVHRFALEILRSSSLWNLLQLFFILFVAFDL MYVRFLFFGESGESLAGYAWLPVFLLIFGVITAYIKQKQSSKKTFVSSLFLMVVITAL EWFPALRVNDEDWLYLMLFPLMACNAFQLLMLPKFAAK*" /label="kbaA CDS" gene 158773..159369 /gene="kbaA" /locus_tag="BSU_01560" /old_locus_tag="BSU01560" /label="kbaA gene" S_feature 159370..160264 /Source="Nicolas_S_feature" /locus_tag="new_159779_160673" /HighExp="Lbstat, Lbtran, M0t90, M40t90, H2O2, BC, Glucon, S7, M40t45, S1" /AntisenseName="ybaN" /AntisenseCor="-2.6735901031407501E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S63" CDS complement(159370..160134) /gene="pdaB" /locus_tag="BSU_01570" /old_locus_tag="BSU01570" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 15598884" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 15598884; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="polysaccharide deacetylase involved in sporulation" /protein_id="NP_388038.1" /db_xref="EnsemblGenomes-Gn:BSU01570" /db_xref="EnsemblGenomes-Tr:CAB11933" /db_xref="GOA:P50865" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014132" /db_xref="SubtiList:BG11416" /db_xref="UniProtKB/Swiss-Prot:P50865" /translation="MNHFYVWHIKRVKQLIIILIAAFAAASFFYIQRAVPLPVFSTDT GPKAIYKGETDSKDISLTFDISWGDERAEPILNTLKANGIKNATFFLSASWAERHPDT VARIVKDGHQIGSMGYAYKNYANLESSEIKKDMNRAQTAFEKLGVKDIQLLRPPTGQF NKNVLKVAKQYNYTVVHYSVNSQDWTNPGVEKIIDNVTKQVSGGDIILLHASDSAKQT EEALPDIIHQLKEKGLKNVTVGDLIANSDAKSAEVK*" /label="pdaB CDS" gene complement(159370..160134) /gene="pdaB" /locus_tag="BSU_01570" /old_locus_tag="BSU01570" /label="pdaB gene" promotor_-10 complement(160165..160183) /Source="Nicolas_upshift_promotors" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(160185) /Source="Nicolas_upshifts" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(160199..160204) /Source="Nicolas_upshift_promotors" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 160242..160249 /Source="Nicolas_upshift_promotors" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 160264..160283 /Source="Nicolas_upshift_promotors" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 160266..160483 /Source="Nicolas_S_feature" /locus_tag="new_160675_160892" /HighExp="Diami, LBGstat, UNK1, H2O2, MG 15, Oxctl, MG-0.1, BMM, T-1.10H, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S64" upshifts 160266 /Source="Nicolas_upshifts" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="upshifts" rRNA 160484..162037 /gene="rrnI-16S" /locus_tag="BSU_rRNA_23" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnI-16S rRNA" gene 160484..162037 /gene="rrnI-16S" /locus_tag="BSU_rRNA_23" /modified_by="User" /label="rrnI-16S gene" Polymorphism join(160830,160832) /Source="geneious" /ID="SNP_BsDelta6_161240_161239" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="C" /Codon_Change /Coverage=45 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="C" /Variant_P_Value="4.2e-57" /Variant_Raw_Frequency=41 /comment="rrnI-16S rRNA" /modified_by="User" / /label="Polymorphism_Delta6" rRNA 162202..165129 /gene="rrnI-23S" /locus_tag="BSU_rRNA_14" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnI-23S rRNA" gene 162202..165129 /gene="rrnI-23S" /locus_tag="BSU_rRNA_14" /label="rrnI-23S gene" rRNA 165185..165301 /gene="rrnI-5S" /locus_tag="BSU_rRNA_15" /product="ribosomal RNA-5S" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnI-5S rRNA" gene 165185..165301 /gene="rrnI-5S" /locus_tag="BSU_rRNA_15" /label="rrnI-5S gene" Polymorphism join(165341,165342) /Source="geneious" /ID="SNP_BsDelta6_165748_165749" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=2 /Amino_Acid_Change /CDS_Position /Change="-TC" /Codon_Change /Coverage="172 -> 174" /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="TC" /Variant_Nucleotides /Variant_P_Value="1.5e-307" /Variant_Raw_Frequency=152 /comment="BSU_tRNA_23_Asn" /modified_by="User" / /label="Polymorphism_Delta6" Polymorphism join(165342,165344) /Source="geneious" /ID="SNP_BsDelta6_165751_165751" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="C -> T" /Codon_Change /Coverage=172 /locus_tag /Protein_Effect /Reference_Frequency="1.2%" /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=168 /comment="BSU_tRNA_23_Asn" /modified_by="User" / /label="Polymorphism_Delta6" tRNA 165346..165417 /gene="trnI-Asn" /locus_tag="BSU_tRNA_23" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asn(GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Asn tRNA" gene 165346..165417 /gene="trnI-Asn" /locus_tag="BSU_tRNA_23" /label="trnI-Asn gene" Polymorphism join(165417,165419) /Source="geneious" /ID="SNP_BsDelta6_165826_165825" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="C" /Codon_Change /Coverage=163 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=160 /comment="BSU_tRNA_23_Asn" /modified_by="User" / /label="Polymorphism_Delta6" tRNA 165423..165495 /gene="trnI-Thr" /locus_tag="BSU_tRNA_24" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(GGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Thr tRNA" gene 165423..165495 /gene="trnI-Thr" /locus_tag="BSU_tRNA_24" /label="trnI-Thr gene" tRNA 165552..165626 /gene="trnI-Gly" /locus_tag="BSU_tRNA_25" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(GCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Gly tRNA" gene 165552..165626 /gene="trnI-Gly" /locus_tag="BSU_tRNA_25" /label="trnI-Gly gene" Polymorphism join(165630,165632) /Source="geneious" /ID="SNP_BsDelta6_166038_166037" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="T" /Codon_Change /Coverage=154 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=148 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" tRNA 165658..165734 /gene="trnI-Arg" /locus_tag="BSU_tRNA_26" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Arg(AGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Arg tRNA" gene 165658..165734 /gene="trnI-Arg" /locus_tag="BSU_tRNA_26" /label="trnI-Arg gene" tRNA 165762..165838 /gene="trnI-Pro" /locus_tag="BSU_tRNA_27" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Pro tRNA" gene 165762..165838 /gene="trnI-Pro" /locus_tag="BSU_tRNA_27" /label="trnI-Pro gene" tRNA 165847..165922 /gene="trnI-Ala" /locus_tag="BSU_tRNA_28" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Ala tRNA" gene 165847..165922 /gene="trnI-Ala" /locus_tag="BSU_tRNA_28" /label="trnI-Ala gene" Polymorphism join(165937,165938) /Source="geneious" /ID="SNP_BsDelta6_166344_166344" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="-G" /Codon_Change /Coverage=132 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides /Variant_P_Value="4.9e-75" /Variant_Raw_Frequency=130 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" rRNA 166093..167646 /gene="rrnH-16S" /locus_tag="BSU_rRNA_16" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnH-16S rRNA" gene 166093..167646 /gene="rrnH-16S" /locus_tag="BSU_rRNA_16" /label="rrnH-16S gene" rRNA 167811..170738 /gene="rrnH-23S" /locus_tag="BSU_rRNA_29" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnH-23S rRNA" gene 167811..170738 /gene="rrnH-23S" /locus_tag="BSU_rRNA_29" /label="rrnH-23S gene" rRNA 170794..170911 /gene="rrnH-5S" /locus_tag="BSU_rRNA_24" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnH-5S rRNA" gene 170794..170911 /gene="rrnH-5S" /locus_tag="BSU_rRNA_24" /label="rrnH-5S gene" rRNA 171095..172648 /gene="rrnG-16S" /locus_tag="BSU_rRNA_25" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnG-16S rRNA" gene 171095..172648 /gene="rrnG-16S" /locus_tag="BSU_rRNA_25" /label="rrnG-16S gene" rRNA 172813..175740 /gene="rrnG-23S" /locus_tag="BSU_rRNA_27" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnG-23S rRNA" gene 172813..175740 /gene="rrnG-23S" /locus_tag="BSU_rRNA_27" /label="rrnG-23S gene" rRNA 175796..175914 /gene="rrnG-5S" /locus_tag="BSU_rRNA_28" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnG-5S rRNA" gene 175796..175914 /gene="rrnG-5S" /locus_tag="BSU_rRNA_28" /label="rrnG-5S gene" S_feature 175915..176523 /Source="Nicolas_S_feature" /locus_tag="new_176316_176924" /HighExp="G180, G135, C30, Oxctl, Paraq, Cold, G150, H2O2, Heat, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S65" promotor_-35 176491..176495 /Source="Nicolas_upshift_promotors" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 176511..176530 /Source="Nicolas_upshift_promotors" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 176525..176681 /Source="Nicolas_S_feature" /locus_tag="new_176926_177082" /HighExp="LBGstat, G180, G135, dia15, C30, Oxctl, LPhT, G150, Heat, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S66" upshifts 176525 /Source="Nicolas_upshifts" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="upshifts" CDS 176682..178118 /gene="ybaR" /locus_tag="BSU_01580" /old_locus_tag="BSU01580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388039.1" /db_xref="EnsemblGenomes-Gn:BSU01580" /db_xref="EnsemblGenomes-Tr:CAB11934" /db_xref="GOA:P55189" /db_xref="InterPro:IPR001902" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR011547" /db_xref="InterPro:IPR018045" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11562" /db_xref="UniProtKB/Swiss-Prot:P55189" /translation="MNNSFTLKQQWFGNIRKDILAGILVALALIPEAIGFSIIAGVDP MVGLYASFCIAIIISIFGGRPGMISAATGSMAVVMVSLVADHGLQYLFAATILTGIIQ VILGISKIARLMKFIPRSVMIGFVNALAILIFSAQLPQFEGASWSMYAMLAGSLVIIY VLPRFTTAVPSPLVAIIVMTIIAVTFHVDVRTVGDMGNISSSLPHFLIPDVPFTFETL QIIFPYSIALAFVGLLESLLTAQIIDEMTDTDSDKNKESRGQGIANIVTGFFGGMAGC AMIGQSVINTKAGGRGRLSAFVAGAFLMFLIAVLSHVVVKIPMAALVAVMVMVSVGTF DWSSLKGLKKAPLTDSIVMVVTVVTVVVTDDLSKGVFVGVLLSAVFFVAKISKLKIVS HAEDQKLRTYQVKGQIFFASVTDLTNAFIYQEDIERVVIDLTEAHVWDDSGAAALDKI VAKFKEQGIEAELKGLNKASKSLMKQMA*" /label="ybaR CDS" gene 176682..178118 /gene="ybaR" /locus_tag="BSU_01580" /old_locus_tag="BSU01580" /label="ybaR gene" downshifts 178107 /Source="Nicolas_upshifts" /id="D56" /incds=0 /nref=144 /ntot=228 /MaxReadThrough="2.81758" /MaxDrop="4.71162" /score="18.4600501" /energy="-12" /TU="NA" /idTUdmin="U111" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 178161..178166 /Source="Nicolas_upshift_promotors" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 178179..178198 /Source="Nicolas_upshift_promotors" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 178197 /Source="Nicolas_upshifts" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="upshifts" CDS 178264..179184 /gene="ybaS" /locus_tag="BSU_01590" /old_locus_tag="BSU01590" /function="7: Transport and binding proteins" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium dependent transporter" /protein_id="NP_388040.2" /db_xref="EnsemblGenomes-Gn:BSU01590" /db_xref="EnsemblGenomes-Tr:CAB11935" /db_xref="GOA:P55190" /db_xref="InterPro:IPR002657" /db_xref="InterPro:IPR004710" /db_xref="SubtiList:BG11563" /db_xref="UniProtKB/Swiss-Prot:P55190" /translation="MPLLTPTSVVLGVLLSQFLNGYEWAVPWIFAFITFAGSLSANFQ SLRHALSHPLPMILALFVLHIFMPLFAWGSGHLIFKGDPLTITGLTLAVVIPTGITSL IWAAMYKGNVGLTLSIILVDTVLSPLIVPLSLSLLAGAQVHMDVWGMMKGLIVMVVIP SFLGMLFNQMSSPERTAFVSSALSPFSKLCLMAVIAINSSAIAPYFKSIDLRFAGIAV TVFFIALTGYAAAWLIGKMMKRRQEEIVSLIFTGGMRNISAGAVLAVTFFPSQVAVPV VIGMLFQQILAALFGYMLNRFELKPMLQKA*" /label="ybaS CDS" gene 178264..179184 /gene="ybaS" /locus_tag="BSU_01590" /old_locus_tag="BSU01590" /label="ybaS gene" downshifts 179165 /Source="Nicolas_upshifts" /id="D57" /incds=0 /nref=33 /ntot=224 /MaxReadThrough="1.3063" /MaxDrop="3.58628" /score="13.3102824" /energy="-10.5" /TU="NA" /idTUdmin="U112" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(179194..179946) /gene="eesA" /locus_tag="BSU_01600" /old_locus_tag="BSU01600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 2974033, 17725565, 22210890, 28283524" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 2974033, 17725565, 22210890, 28283524; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-chelator (enterobactin family) esterase" /protein_id="NP_388041.2" /db_xref="EnsemblGenomes-Gn:BSU01600" /db_xref="EnsemblGenomes-Tr:CAB11936" /db_xref="GOA:P55192" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11565" /db_xref="UniProtKB/Swiss-Prot:P55192" /translation="MKGSLSEHKAGNRRFTLYLPPSYSTDSGGFPAVYVQDGSSLFQN QIELLESAFQQQRLPELVLIGIEPENRLDEYTPWPAASLSDRFTDFGGMGYHYLSDIT NQFIPLIEENWNVTREPQSRGMIGASLGGLISMFAILKYPSMFGKIGSISGSYWYENA AETIHISSLKPGTARVFMSIGSEEGREKQSIQRHMLKKTKQVHQSLKEKGFTEDQLCL SIEKGAVHHHKYFCKQFINALEWLYGKNRSTL*" /label="eesA CDS" gene complement(179194..179946) /gene="eesA" /locus_tag="BSU_01600" /old_locus_tag="BSU01600" /label="eesA gene" downshifts complement(179218) /Source="Nicolas_upshifts" /id="D58" /incds=0 /nref=15 /ntot=115 /MaxReadThrough="0.3819" /MaxDrop="4.57603" /score="25.9728338" /energy="-10.5" /TU="NA" /idTUdmin="U114" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(179943..180953) /gene="feuC" /locus_tag="BSU_01610" /old_locus_tag="BSU01610" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2651410, 15849754, 16850406, 27375568; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-uptake protein" /protein_id="NP_388042.2" /db_xref="EnsemblGenomes-Gn:BSU01610" /db_xref="EnsemblGenomes-Tr:CAB11937" /db_xref="GOA:P40411" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10837" /db_xref="UniProtKB/Swiss-Prot:P40411" /translation="MAKKYALFIALILVVSYFSLTSGSFSVRPAELLSTLFQIDPNPQ YEILLFDLRLPRVVMAAIIGLGLGIAGAVIQAITRNGLADPGILGINAGAGAGIVAFM LLFQGQKEVTSIAAAMGMPLFGLIGGLIAAILIYIFAWHRGNLDSGRIILVGIAINSG FSALSLFLSLKMDPQDYQMAMVWKNGSIWSANWTYITAVLPWMLLFIPILIGKSRLLD TIRFDEDTVRSLGISSNKEKTILLVACVAIISACVSVAGSMAFVGLIAPHISRRLAGV EHRYILPLSGLIGMLLVISADFAGKLFFQPAEVPAGIILAILGVPYFLYLLFKQKKGE NA*" /label="feuC CDS" gene complement(179943..180953) /gene="feuC" /locus_tag="BSU_01610" /old_locus_tag="BSU01610" /label="feuC gene" CDS complement(180946..181950) /gene="feuB" /locus_tag="BSU_01620" /old_locus_tag="BSU01620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2651410, 15849754, 16850406, 17725565; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferri-bacillibactin permease" /protein_id="NP_388043.1" /db_xref="EnsemblGenomes-Gn:BSU01620" /db_xref="EnsemblGenomes-Tr:CAB11938" /db_xref="GOA:P40410" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10836" /db_xref="UniProtKB/Swiss-Prot:P40410" /translation="MYSKQWTRIILITSPFAIALSLLLSILYGAKHLSTDIVFTSLIH FDPGNTDHQIIWHSRIPRAAGALLIGAALAVSGALMQGITRNYLASPSIMGVSDGSAF IITLCMVLLPQSSSIEMMIYSFIGSALGAVLVFGLAAMMPNGFTPVQLAIIGTVTSML LSSLSAAMSIYFQISQDLSFWYSARLHQMSPDFLKLAAPFFLIGIIMAISLSKKVTAV SLGDDISKSLGQKKKTIKIMAMLSVIILTGSAVALAGKIAFVGLVVPHITRFLVGSDY SRLIPCSCILGGIFLTLCDLASRFINYPFETPIEVVTSIIGVPFFLYLIKRKGGEQNG *" /label="feuB CDS" gene complement(180946..181950) /gene="feuB" /locus_tag="BSU_01620" /old_locus_tag="BSU01620" /label="feuB gene" CDS complement(181969..182922) /gene="feuA" /locus_tag="BSU_01630" /old_locus_tag="BSU01630" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8388528, 16889643, 17725565, 21802011, 22303020, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8388528, 16889643, 17725565, 21802011, 22303020, 25355936; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="ferri-bacillibactin-binding lipoprotein" /protein_id="NP_388044.1" /db_xref="EnsemblGenomes-Gn:BSU01630" /db_xref="EnsemblGenomes-Tr:CAB11939" /db_xref="GOA:P40409" /db_xref="InterPro:IPR002491" /db_xref="PDB:2PHZ" /db_xref="PDB:2WHY" /db_xref="PDB:2WI8" /db_xref="PDB:2XUZ" /db_xref="PDB:2XV1" /db_xref="SubtiList:BG10835" /db_xref="UniProtKB/Swiss-Prot:P40409" /translation="MKKISLTLLILLLALTAAACGSKNESTASKASGTASEKKKIEYL DKTYEVTVPTDKIAITGSVESMEDAKLLDVHPQGAISFSGKFPDMFKDITDKAEPTGE KMEPNIEKILEMKPDVILASTKFPEKTLQKISTAGTTIPVSHISSNWKENMMLLAQLT GKEKKAKKIIADYEQDLKEIKTKINDKAKDSKALVIRIRQGNIYIYPEQVYFNSTLYG DLGLKAPNEVKAAKAQELSSLEKLSEMNPDHIFVQFSDDENADKPDALKDLEKNPIWK SLKAVKEDHVYVNSVDPLAQGGTAWSKVRFLKAAAEKLTQN*" /label="feuA CDS" gene complement(181969..182922) /gene="feuA" /locus_tag="BSU_01630" /old_locus_tag="BSU01630" /label="feuA gene" promotor_-35 182282..182288 /Source="Nicolas_upshift_promotors" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 182303..182321 /Source="Nicolas_upshift_promotors" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 182312 /Source="Nicolas_upshifts" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(182953..182972) /Source="Nicolas_upshift_promotors" /id="U114" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.984015984015984" /xcortree=2097 /SigmaFactorBS="gtccatgataaatcaggaatttgtccatggtgttatatctgt tcattcTCTATAATTCCAATTGATAAtagttatcaattgaacaggaggctctatagat g" /listShort="feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(182960) /Source="Nicolas_upshifts" /id="U114" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.984015984015984" /xcortree=2097 /SigmaFactorBS="gtccatgataaatcaggaatttgtccatggtgttatatctgt tcattcTCTATAATTCCAATTGATAAtagttatcaattgaacaggaggctctatagat g" /listShort="feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(183013..184602) /gene="btr" /locus_tag="BSU_01640" /old_locus_tag="BSU01640" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16889643, 17725565, 17962296, 22210890" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16889643, 17725565, 17962296, 22210890; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator (AraC/XylS family) of synthesis and uptake of the siderophore bacillibactin" /protein_id="NP_388045.1" /db_xref="EnsemblGenomes-Gn:BSU01640" /db_xref="EnsemblGenomes-Tr:CAB11940" /db_xref="GOA:P40408" /db_xref="InterPro:IPR002491" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="SubtiList:BG10834" /db_xref="UniProtKB/Swiss-Prot:P40408" /translation="MQNAVIYQPVQIEYLKKTSDLFSEQQLADSFVLIFHLKGNGYIS IGTNTNPLQKKTLYVCPPNETFGFTPAADGHIDACIIRLLSYIKETGQDIFTPCTESE LAKLKLMNVSHIENLAVRLQELAALWNESSQLSQLKCVIEVQSLIYDLFTASLSDQTD THSAIEKTKHYIETHADTKITLAQLSQMAGISAKHYSESFKKWTGQSVTEFITKTRIT KAKRLMAKSNCKLKEIAHQTGYQDEFYFSRIFKKYTGCSPTSYMKKRRKKIAAYGRGT MGHLIPLHHIPFAAALHPKWTSYYYQHYSTDIPVQLSAYRFNEKWEENLYTLSQAEPD VIVSMDSISPEEQDRLNRIAEVMYLPSEESWRTHFLQTASFLKEESEAEKWLADYDQQ TTAAKKTLQHVQGLRFLFLRLHKQNFYLAHNRSVREVFFGDLGFSSATTADTPSEQAI SLENIANYQADCMMLFLFKEPETIAYYQQLQQTEAWQNLSAVRDNRVYLLSLDPWNEY SACGHERIVQQTVSLLSGDCP*" /label="btr CDS" gene complement(183013..184602) /gene="btr" /locus_tag="BSU_01640" /old_locus_tag="BSU01640" /label="btr gene" promotor_-10 complement(184643..184662) /Source="Nicolas_upshift_promotors" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(184655) /Source="Nicolas_upshifts" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(184677..184684) /Source="Nicolas_upshift_promotors" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(184764) /Source="Nicolas_upshifts" /id="D59" /incds=0 /nref=19 /ntot=58 /MaxReadThrough="1.28464" /MaxDrop="7.13916" /score="9.64466628" /energy="-10.1" /TU="NA" /idTUdmin="U116" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(184793..186037) /gene="ybbC" /locus_tag="BSU_01650" /old_locus_tag="BSU01650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388046.1" /db_xref="EnsemblGenomes-Gn:BSU01650" /db_xref="EnsemblGenomes-Tr:CAB11941" /db_xref="InterPro:IPR008302" /db_xref="SubtiList:BG10833" /db_xref="UniProtKB/Swiss-Prot:P40407" /translation="MRKTIFAFLTGLMMFGTITAASASPDSKNQTAKKPKVQTGIDTL LPDYKKQLKGKRIGLITNPAGVNTSLKSSVDILYENPDIKLTALFGPEHGVRGDAQAG DEVGSYIDEKTGVPVYSLYGKTKKPTPEMLKNVDILMFDIQDVGTRFYTYIYTMAYAM EAAKENGIPFMVLDRPNPQGGNHIEGPILEPEYASFVGLYPIPLKHGMTIGELASLFN KEFSIDADLTVVKMKHWKRKMDFDDTRLPFVLPSPNMPTVESTFVYPATGLIEGTNIS EGRGTTKPFELIGAPFIKSTELEETLNSLHLPGVTFRAASFTPTFSKHQGTLCHGVQL YVTDRDKFEAVKTGLSVIKTIHDLYPEDFEFLSTGSFDKLAGNGWIRTKIENGTSVEN IINSYEKTLQQFSKTRKKYLIY*" /label="ybbC CDS" gene complement(184793..186037) /gene="ybbC" /locus_tag="BSU_01650" /old_locus_tag="BSU01650" /label="ybbC gene" downshifts complement(184814) /Source="Nicolas_upshifts" /id="D60" /incds=0 /nref=11 /ntot=122 /MaxReadThrough="7.66074" /MaxDrop="4.10379" /score="9.64466628" /energy="-10.1" /TU="U116" /idTUdmin="U116" /TUdmin="-50" /isTUend="FALSE" /label="downshifts" CDS complement(186051..187979) /gene="nagZ" /locus_tag="BSU_01660" /old_locus_tag="BSU01660" /EC_number="3.2.1.52" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8063094, 20400549, 20826810, 23177201, 26963691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8063094, 20400549, 20826810, 23177201, 26963691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglucosaminidase lipoprotein" /protein_id="NP_388047.1" /db_xref="EnsemblGenomes-Gn:BSU01660" /db_xref="EnsemblGenomes-Tr:CAB11942" /db_xref="GOA:P40406" /db_xref="InterPro:IPR001764" /db_xref="InterPro:IPR002772" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR019800" /db_xref="InterPro:IPR036881" /db_xref="InterPro:IPR036962" /db_xref="PDB:3BMX" /db_xref="PDB:3LK6" /db_xref="PDB:3NVD" /db_xref="PDB:4GYJ" /db_xref="PDB:4GYK" /db_xref="SubtiList:BG10832" /db_xref="UniProtKB/Swiss-Prot:P40406" /translation="MRPVFPLILSAVLFLSCFFGARQTEASASKRAIDANQIVNRMSL DEKLGQMLMPDFRNWQKEGESSPQALTKMNDEVASLVKKYQFGGIILFAENVKTTKQT VQLTDDYQKASPKIPLMLSIDQEGGIVTRLGEGTNFPGNMALGAARSRINAYQTGSII GKELSALGINTDFSPVVDINNNPDNPVIGVRSFSSNRELTSRLGLYTMKGLQRQDIAS ALKHFPGHGDTDVDSHYGLPLVSHGQERLREVELYPFQKAIDAGADMVMTAHVQFPAF DDTTYKSKLDGSDILVPATLSKKVMTGLLRQEMGFNGVIVTDALNMKAIADHFGQEEA VVMAVKAGVDIALMPASVTSLKEEQKFARVIQALKEAVKNGDIPEQQINNSVERIISL KIKRGMYPARNSDSTKEKIAKAKKIVGSKQHLKAEKKLAEKAVTVLKNEQHTLPFKPK KGSRILIVAPYEEQTASIEQTIHDLIKRKKIKPVSLSKMNFASQVFKTEHEKQVKEAD YIITGSYVVKNDPVVNDGVIDDTISDSSKWATVFPRAVMKAALQHNKPFVLMSLRNPY DAANFEEAKALIAVYGFKGYANGRYLQPNIPAGVMAIFGQAKPKGTLPVDIPSVTKPG NTLYPLGYGLNIKTGRPL*" /label="nagZ CDS" gene complement(186051..187979) /gene="nagZ" /locus_tag="BSU_01660" /old_locus_tag="BSU01660" /label="nagZ gene" CDS complement(188007..189332) /gene="amiE" /locus_tag="BSU_01670" /old_locus_tag="BSU01670" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16452451, 20400549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16452451, 20400549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="amidase hydrolyzing N-acetylmuramyl-L-Ala bond of MurNAc peptides" /protein_id="NP_388048.2" /db_xref="EnsemblGenomes-Gn:BSU01670" /db_xref="EnsemblGenomes-Tr:CAB11943" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR022849" /db_xref="SubtiList:BG11566" /db_xref="UniProtKB/Swiss-Prot:O05213" /translation="MKTKTLFIFSAILTLSIFAPNETFAQTAGNLIEPKIINAETAQF STKKLRKVDQMIERDIAAGFPGAVLVVVKDGRIIKKAAYGYSKKYEGSELLRRPAKMK TRTMFDLASNTKMYATNFALQRLVSQGKLDVYEKVSAYLPGFKDQPGDLIKGKDKIRV IDVLQHQSGLPSSFYFYTPEKAGKYYSQERDKTIEYLTKIPLDYQTGTKHVYSDIGYM LLGCIVEKLTGKPLDVYTEQELYKPLRLKHTLYNPLQKGFKPKQFAATERMGNTRDGV IQFPNIRTNTLQGEVHDEKAFYSMDGVSGHAGLFSNADDMAILLQVMLNKGSYRNISL FDQKTADLFTAPSATDPTFALGWRRNGSKSMEWMFGPHASENAYGHTGWTGTVTIIDP AYNLGIALLTNKKHTPVIDPEENPNVFEGDQFPTGSYGSVITAIYEAME*" /label="amiE CDS" gene complement(188007..189332) /gene="amiE" /locus_tag="BSU_01670" /old_locus_tag="BSU01670" /label="amiE gene" CDS complement(189389..190756) /gene="murP" /locus_tag="BSU_01680" /old_locus_tag="BSU01680" /EC_number="2.7.1.192" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15060041, 15849754, 16850406, 10627040, 20400549, 22960854; Product type t : transporter" /codon_start=1 /transl_table=11 /product="N-acetylmuramic acid PTS permease-MurP subunit" /protein_id="NP_388049.3" /db_xref="EnsemblGenomes-Gn:BSU01680" /db_xref="EnsemblGenomes-Tr:CAB11944" /db_xref="GOA:Q797S1" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11567" /db_xref="UniProtKB/Swiss-Prot:Q797S1" /translation="MSKENNYHHLAQKILELCGGKSNISSYTHCMTRLRITPYDESKA DAQALRKLDGVLGVVEAETLQIILGTGVVNHVTAAFSKLVSAEEGADVKEAAAKKKAD INRKNATPFKLFLRKIASIFIPLIPALVASGLITGITKAIIQAGWLSADSQIAIILTV IGSGLFTYLGILVGINASKEFGGTPALGALAGILIINPEIAKISLFGEELLPGRGGLI GVLFAAIFIAYTEQFIRRFIPQSLDIIVTPTVSLLITGIVTYVVFMPLGGFISDAITS GLLSILDIGGIAAGFILGATFLPLVVTGLHQGLTPVHMELINSIGNDPLLPILAMGGA GQVGAAFAVFVKTKKTTLRKAIAGGLPSGLLGIGEPLIFGVTLPLGRPFLTACLGAGI GGAFQAYFQVATIAIGVSGLPLSFLVLPSQIILYIVGLFISYAAGFLLTYAFGYKDEM ASQFD*" /label="murP CDS" gene complement(189389..190756) /gene="murP" /locus_tag="BSU_01680" /old_locus_tag="BSU01680" /label="murP gene" CDS complement(190782..191633) /gene="murR" /locus_tag="BSU_01690" /old_locus_tag="BSU01690" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 20400549; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator MurR-N-acetylmuramic acid" /protein_id="NP_388050.1" /db_xref="EnsemblGenomes-Gn:BSU01690" /db_xref="EnsemblGenomes-Tr:CAB11945" /db_xref="GOA:Q45581" /db_xref="InterPro:IPR000281" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR035472" /db_xref="InterPro:IPR036388" /db_xref="PDB:2O3F" /db_xref="SubtiList:BG11569" /db_xref="UniProtKB/Swiss-Prot:Q45581" /translation="MATGGLAIIQSMKHKLPPSERKLADYILAHPHKAIESTVNEISA LANSSDAAVIRLCKSLGLKGFQDLKMRVAGDLAKPTFQGYRDIVPHEPLPSISEKTAG NAIQAIQDTSDLMDYKELERAVSLLLKAHTVHFIGLGASGIVAKDAQQKWLRIHKQAT AFTDTHLVASLIANADKDDIVFAISFSGETQEIVELFAMAKEKGITTISLTQFSQTSV SALADVPLYTAHSNEALIRSAATSSRLAQLFIIDVLFLGMAAEQYETTTGYIDKTRAA IQSMRIK*" /label="murR CDS" gene complement(190782..191633) /gene="murR" /locus_tag="BSU_01690" /old_locus_tag="BSU01690" /label="murR gene" CDS complement(191650..192564) /gene="murQ" /locus_tag="BSU_01700" /old_locus_tag="BSU01700" /EC_number="4.2.1.126" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15983044, 20400549, 16452451; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-lactyl ether N-acetylmuramic-6-phosphate acid etherase" /protein_id="NP_388051.1" /db_xref="EnsemblGenomes-Gn:BSU01700" /db_xref="EnsemblGenomes-Tr:CAB11946" /db_xref="GOA:Q45582" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR005486" /db_xref="InterPro:IPR005488" /db_xref="SubtiList:BG11570" /db_xref="UniProtKB/Swiss-Prot:Q45582" /translation="MSEPLNLHRLTTESRNSQTVEIHKANTLGILKMINNEDMKVAAA VQEVLPDIKTAVDCAYESFQNGGRLIYTGAGTSGRLGVMDAVECPPTYSVSPDQVIGI MAGGPEAFLQAAEGIEDSEEAGAEDLRNIQLTSNDTVIAIAASGRTPYAAGALRYARK VGAHTIALTCNENSAISKDADHSIEVVVGPEAITGSTRMKAATAHKMILNMISTAVMV KIGKVYENLMVDVNVSNKKLKERAISIIQSLTNASYDTARYTLEQADHHVKTAIVMLK TSTDQKQAQTLLDEANGFIDKAIEHYHP*" /label="murQ CDS" gene complement(191650..192564) /gene="murQ" /locus_tag="BSU_01700" /old_locus_tag="BSU01700" /label="murQ gene" promotor_-10 complement(192595..192613) /Source="Nicolas_upshift_promotors" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(192608) /Source="Nicolas_upshifts" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(192629..192636) /Source="Nicolas_upshift_promotors" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(192674..193156) /gene="ybbJ" /locus_tag="BSU_01710" /old_locus_tag="BSU01710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_388052.2" /db_xref="EnsemblGenomes-Gn:BSU01710" /db_xref="EnsemblGenomes-Tr:CAB11947" /db_xref="GOA:Q45583" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11571" /db_xref="UniProtKB/Swiss-Prot:Q45583" /translation="MTQDISLSFYKPEHLPELQSFTLTNDDKRFTSLPKEVLSQALGI QDRYPVVILKDDLPVGFFILHASKETLASYSNNPFALLLSSLSLTAVHHGKGYAKKAM LLLPAFVSGYFPWCDEIILAVNHLNIRAKHLYMKSGFLDKGRRRIGPLGEQLILHHFL *" /label="ybbJ CDS" gene complement(192674..193156) /gene="ybbJ" /locus_tag="BSU_01710" /old_locus_tag="BSU01710" /label="ybbJ gene" CDS complement(193169..193624) /gene="ybbK" /locus_tag="BSU_01720" /old_locus_tag="BSU01720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388053.2" /db_xref="EnsemblGenomes-Gn:BSU01720" /db_xref="EnsemblGenomes-Tr:CAB11948" /db_xref="InterPro:IPR007553" /db_xref="SubtiList:BG11572" /db_xref="UniProtKB/Swiss-Prot:Q45584" /translation="MILVSSCLGGIECRYNGSHAASEKIRKLVDEKKAVMACPELLGG FSTPREPAEIIGGTGEDVLNGTAKIVTASGEDVTELYMEGAAKTLAYAKEINASAVIL KENSPSCGSGFIYNGTFSGKKITGSGVTAALLKQAGYRVISENELNDIL*" /label="ybbK CDS" gene complement(193169..193624) /gene="ybbK" /locus_tag="BSU_01720" /old_locus_tag="BSU01720" /label="ybbK gene" promotor_-10 complement(193650..193669) /Source="Nicolas_upshift_promotors" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(193671) /Source="Nicolas_upshifts" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(193684..193685) /Source="Nicolas_upshift_promotors" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 193744..193751 /Source="Nicolas_upshift_promotors" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-35" promotor_-10 193766..193785 /Source="Nicolas_upshift_promotors" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-10" upshifts 193777 /Source="Nicolas_upshifts" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="upshifts" tRNA 193804..193878 /gene="trnSL-Glu2" /locus_tag="BSU_tRNA_75" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Glu(UUC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Glu2 tRNA" gene 193804..193878 /gene="trnSL-Glu2" /locus_tag="BSU_tRNA_75" /label="trnSL-Glu2 gene" tRNA 193882..193957 /gene="trnSL-Val1" /locus_tag="BSU_tRNA_78" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Val1 tRNA" gene 193882..193957 /gene="trnSL-Val1" /locus_tag="BSU_tRNA_78" /label="trnSL-Val1 gene" tRNA 193962..194034 /gene="trnSL-Thr1" /locus_tag="BSU_tRNA_76" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Thr1 tRNA" gene 193962..194034 /gene="trnSL-Thr1" /locus_tag="BSU_tRNA_76" /label="trnSL-Thr1 gene" tRNA 194057..194141 /gene="trnSL-Tyr1" /locus_tag="BSU_tRNA_77" /product="tRNA-Tyr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Tyr(GAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Tyr1 tRNA" gene 194057..194141 /gene="trnSL-Tyr1" /locus_tag="BSU_tRNA_77" /label="trnSL-Tyr1 gene" tRNA 194146..194220 /gene="trnSL-Gln2" /locus_tag="BSU_tRNA_74" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Gln2 tRNA" gene 194146..194220 /gene="trnSL-Gln2" /locus_tag="BSU_tRNA_74" /label="trnSL-Gln2 gene" downshifts 194223 /Source="Nicolas_upshifts" /id="D61" /incds=0 /nref=10 /ntot=91 /MaxReadThrough="4.25215" /MaxDrop="3.84626" /score="25.5087424" /energy="-11.4" /TU="U118" /idTUdmin="U118" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" S_feature 194268..194385 /Source="Nicolas_S_feature" /locus_tag="new_194669_194786" /HighExp="Paraq, BMM, H2O2, Heat, G180, G135, Oxctl, G150, C30, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S67" promotor_-35 194386..194395 /Source="Nicolas_upshift_promotors" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-35" upshifts 194387 /Source="Nicolas_upshifts" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="upshifts" promotor_-10 194407..194422 /Source="Nicolas_upshift_promotors" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-10" CDS 194448..195011 /gene="sigW" /locus_tag="BSU_01730" /old_locus_tag="BSU01730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11866510, 15130127, 16629676, 21542858, 28319136, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11866510, 15130127, 16629676, 21542858, 28319136, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor W" /protein_id="NP_388054.1" /db_xref="EnsemblGenomes-Gn:BSU01730" /db_xref="EnsemblGenomes-Tr:CAB11949" /db_xref="GOA:Q45585" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014294" /db_xref="InterPro:IPR036388" /db_xref="PDB:5WUQ" /db_xref="PDB:5WUR" /db_xref="SubtiList:BG11573" /db_xref="UniProtKB/Swiss-Prot:Q45585" /translation="MEMMIKKRIKQVKKGDQDAFADIVDIYKDKIYQLCYRMLGNVHE AEDIAQEAFIRAYVNIDSFDINRKFSTWLYRIATNLTIDRIRKKKPDYYLDAEVAGTE GLTMYSQIVADGVLPEDAVVSLELSNTIQQKILKLPDKYRTVIVLKYIDELSLIEIGE ILNIPVGTVKTRIHRGREALRKQLRDL*" /label="sigW CDS" gene 194448..195011 /gene="sigW" /locus_tag="BSU_01730" /old_locus_tag="BSU01730" /label="sigW gene" CDS 195025..195651 /gene="rsiW" /locus_tag="BSU_01740" /old_locus_tag="BSU01740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15130127, 28319136, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130127, 28319136, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma(W) factor" /protein_id="NP_388055.1" /db_xref="EnsemblGenomes-Gn:BSU01740" /db_xref="EnsemblGenomes-Tr:CAB11950" /db_xref="GOA:Q45588" /db_xref="InterPro:IPR027383" /db_xref="PDB:5WUQ" /db_xref="PDB:5WUR" /db_xref="SubtiList:BG11574" /db_xref="UniProtKB/Swiss-Prot:Q45588" /translation="MSCPEQIVQLMHMHLDGDILPKDEHVLNEHLETCEKCRKHFYEM EKSIALVRSTSHVEAPADFTANVMAKLPKEKKRASVKRWFRTHPVIAAAAVFIILMGG GFFNSWHNDHNFSVSKQPNLVVHNHTVTVPEGETVKGDVTVKNGKLIIKGKIDGDVTV VNGEKYMASAGQVTGQIEEINQLFDWTWYKMKSAGKSVLDAFNPNGEE*" /label="rsiW CDS" gene 195025..195651 /gene="rsiW" /locus_tag="BSU_01740" /old_locus_tag="BSU01740" /label="rsiW gene" downshifts complement(195443) /Source="Nicolas_upshifts" /id="D62" /incds=1 /nref=2 /ntot=181 /MaxReadThrough="1.52124" /MaxDrop="3.24828" /score="0.305471631" /energy="-6.9" /TU="NA" /idTUdmin="U120" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(195601..195701) /Source="Nicolas_upshift_promotors" /id="U120" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.002997002997003" /xcortree=56 /SigmaFactorBS="tgtgccagccctctcagcccgcaaaaaaagagcaaagcggct aacgcgctttactcttctccgttcggattgaatgcatcgagtacacttttccccgcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" downshifts 195631 /Source="Nicolas_upshifts" /id="D63" /incds=0 /nref=251 /ntot=269 /MaxReadThrough="4.26924" /MaxDrop="8.34597" /score="7.39786279" /energy="-10.8" /TU="U119" /idTUdmin="U119" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" upshifts complement(195641) /Source="Nicolas_upshifts" /id="U120" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.002997002997003" /xcortree=56 /SigmaFactorBS="tgtgccagccctctcagcccgcaaaaaaagagcaaagcggct aacgcgctttactcttctccgttcggattgaatgcatcgagtacacttttccccgcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 195700..195707 /Source="Nicolas_upshift_promotors" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="promotor_-35" promotor_-10 195722..195741 /Source="Nicolas_upshift_promotors" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="promotor_-10" S_feature 195731..195811 /Source="Nicolas_S_feature" /locus_tag="new_196132_196212" /HighExp="dia5, Diami, H2O2, dia15, G135, Cold, G180, Paraq, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY, SigA" /TUlongPSig="1, 1" /label="S68" upshifts 195731 /Source="Nicolas_upshifts" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="upshifts" CDS 195812..196633 /gene="cdaA" /locus_tag="BSU_01750" /old_locus_tag="BSU01750" /EC_number="2.7.7.85" /function="16.13: Shape" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:19901023, 21566650, 23192352, 25605729, 25616256, 26240071, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19901023, 21566650, 23192352, 25605729, 25616256, 26240071, 28420751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diadenylate cyclase" /protein_id="NP_388056.2" /db_xref="EnsemblGenomes-Gn:BSU01750" /db_xref="EnsemblGenomes-Tr:CAB11951" /db_xref="GOA:Q45589" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR014046" /db_xref="InterPro:IPR034701" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG11577" /db_xref="UniProtKB/Swiss-Prot:Q45589" /translation="MAFEDIPFLQYLGNAVDILLVWYVIYKLIMVIRGTKAVQLLKGI VVIVLVRMASQYLGLSTLQWLMDQAITWGFLAIIIIFQPELRRALEQLGRGRFFSRSG TPVEEAQQKTIEAITKAINYMAKRRIGALLTIERDTGMGDYIETGIPLNAKVSSELLI NIFIPNTPLHDGAVIMKNNEIAAAACYLPLSESPFISKELGTRHRAAVGISEVTDSLT IIVSEETGGVSVAKNGDLHRELTEEALKEMLEAEFKKNTRDTSSNRWYWRGKKNG*" /label="cdaA CDS" gene 195812..196633 /gene="cdaA" /locus_tag="BSU_01750" /old_locus_tag="BSU01750" /label="cdaA gene" CDS 196626..198077 /gene="cdaR" /locus_tag="BSU_01760" /old_locus_tag="BSU01760" /experiment="publication(s) with functional evidences, PMID:16236721, 17406245, 20094656, 21154411, 22720735, 23192352, 27074767" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16236721, 17406245, 20094656, 21154411, 22720735, 23192352, 27074767; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of diadenylate cyclase activity" /protein_id="NP_388057.2" /db_xref="EnsemblGenomes-Gn:BSU01760" /db_xref="EnsemblGenomes-Tr:CAB11952" /db_xref="GOA:O34659" /db_xref="InterPro:IPR012505" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12703" /db_xref="UniProtKB/Swiss-Prot:O34659" /translation="MDKFLNNRWAVKIIALLFALLLYVAVNSNQAPTPKKPGESFFPT STTDEATLTDIPVKAYYDDENYVVTGVPQTVNVTIKGSTSAVKKARQTKNFEIYADME HLKTGTHKVELKAKNVSDGLTISINPSVTTVTIQERTTKSFPVEVEYYNKSKMKKGYS PEQPIVSPKNVQITGSKNVIDNISLVKASVNLENADETIEKEAKVTVYDKDGNALPVD VEPSVIKITVPVTSPSKKVPFKIERTGSLPDGVSIANIESSPSEVTVYGSQDVLDSLE FIDGVSLDLSKINKDSDIEADIPLPDGVKKISPSKVTLHIEVDSEADQKFENVPIKTV GLSSSQNIEFLDPESQAIDVTAKGSPTNINKLKKSDIELYVNVSDLEDGEHSVKLEVN GPQNVTWSLGRKNAKIKLTSKKSNTSTNDNSSNTSGNQDTDKQTNDQKNNQQEDTKNT DKNNNDQNQDGNKDQNQDQDEDESTANSQSSSE*" /label="cdaR CDS" gene 196626..198077 /gene="cdaR" /locus_tag="BSU_01760" /old_locus_tag="BSU01760" /label="cdaR gene" CDS 198096..199442 /gene="glmM" /locus_tag="BSU_01770" /old_locus_tag="BSU01770" /EC_number="5.4.2.10" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10671448, 10913078, 12089032, 21154411, 26240071, 27074767" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10671448, 10913078, 12089032, 21154411, 26240071, 27074767; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphoglucosamine mutase" /protein_id="NP_388058.1" /db_xref="EnsemblGenomes-Gn:BSU01770" /db_xref="EnsemblGenomes-Tr:CAB11953" /db_xref="GOA:O34824" /db_xref="InterPro:IPR005841" /db_xref="InterPro:IPR005843" /db_xref="InterPro:IPR005844" /db_xref="InterPro:IPR005845" /db_xref="InterPro:IPR005846" /db_xref="InterPro:IPR006352" /db_xref="InterPro:IPR016055" /db_xref="InterPro:IPR016066" /db_xref="InterPro:IPR036900" /db_xref="SubtiList:BG12704" /db_xref="UniProtKB/Swiss-Prot:O34824" /translation="MGKYFGTDGVRGVANSELTPELAFKVGRFGGYVLTKDKQRPKVL IGRDTRISGHMLEGALVAGLLSIGAEVMRLGVISTPGVSYLTKAMDAEAGVMISASHN PVQDNGIKFFGGDGFKLSDEQEAEIERLMDEPEDKLPRPVGADLGLVNDYFEGGQKYL QFLKQTADEDFTGIHVALDCANGATSSLATHLFADLDADVSTMGTSPNGLNINDGVGS THPEALSAFVKEKNADLGLAFDGDGDRLIAVDEKGNIVDGDQIMYICSKHLKSEGRLK DDTVVSTVMSNLGFYKALEKEGIKSVQTAVGDRYVVEAMKKDGYNVGGEQSGHLIFLD YNTTGDGLLSAIMLMNTLKATGKPLSELAAEMQKFPQLLVNVRVTDKYKVEENEKVKA VISEVEKEMNGDGRILVRPSGTEPLVRVMAEAKTKELCDEYVNRIVEVVRSEMGLE*" /label="glmM CDS" gene 198096..199442 /gene="glmM" /locus_tag="BSU_01770" /old_locus_tag="BSU01770" /label="glmM gene" downshifts 199437 /Source="Nicolas_upshifts" /id="D64" /incds=0 /nref=126 /ntot=216 /MaxReadThrough="5.32721" /MaxDrop="5.02497" /score="13.5044076" /energy="-17.5" /TU="U121" /idTUdmin="U121" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" promotor_-35 199461..199469 /Source="Nicolas_upshift_promotors" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 199477 /Source="Nicolas_upshifts" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 199483..199502 /Source="Nicolas_upshift_promotors" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 199529..199534 /Source="Nicolas_upshift_promotors" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 199550..199569 /Source="Nicolas_upshift_promotors" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 199556 /Source="Nicolas_upshifts" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="upshifts" misc_feature 199600..199616 /Source="Nicolas_upshift_promotors" /id="U124" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=336 /SigmaFactorBS="taaaatcaagcttgtcttgttcttattttctcaataggaaaa gaagaCGGGATTATTGCTTTACctataattatagcgcccgaactaagcgcccggaaaa a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 199613 /Source="Nicolas_upshifts" /id="U124" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=336 /SigmaFactorBS="taaaatcaagcttgtcttgttcttattttctcaataggaaaa gaagaCGGGATTATTGCTTTACctataattatagcgcccgaactaagcgcccggaaaa a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 199616..199786 /gene="glmSA" /locus_tag="BSU_misc_RNA_5" /product="riboswitch and ribozyme (GlmS-glucosamine-6-P)" /experiment="publication(s) with functional evidences, PMID:16298301, 16484375, 16990543, 17114942, 17283212, 18079181, 19228039, 21317896, 21395279, 21936556, 25038539, 26240071, 28012261" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16298301, 16484375, 16990543, 17114942, 17283212, 18079181, 19228039, 21317896, 21395279, 21936556, 25038539, 26240071, 28012261; Product type n: RNA" /label="glmSA RNA" gene 199616..199786 /gene="glmSA" /locus_tag="BSU_misc_RNA_5" /label="glmSA gene" S_feature 199787..199875 /Source="Nicolas_S_feature" /locus_tag="new_200188_200276" /HighExp="M40t90, M0t90, M9-stat, Lbstat, T2.30H, T2.0H, T3.0H, T1.30H, T1.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigK" /TUshortPSig="0.498, 0.999, 0.754" /TUlongSig="SigA, SigWXY, SigA" /TUlongPSig="1, 1, 1" /label="S69" CDS 199876..201678 /gene="glmS" /locus_tag="BSU_01780" /old_locus_tag="BSU01780" /EC_number="2.6.1.16" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15029187, 17114942, 17283212, 17322533, 23874669; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="L-glutamine-D-fructose-6-phosphate amidotransferase" /protein_id="NP_388059.1" /db_xref="EnsemblGenomes-Gn:BSU01780" /db_xref="EnsemblGenomes-Tr:CAB11954" /db_xref="GOA:P0CI73" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR005855" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR035466" /db_xref="InterPro:IPR035490" /db_xref="SubtiList:BG10948" /db_xref="UniProtKB/Swiss-Prot:P0CI73" /translation="MCGIVGYIGQLDAKEILLKGLEKLEYRGYDSAGIAVANEQGIHV FKEKGRIADLREVVDANVEAKAGIGHTRWATHGEPSYLNAHPHQSALGRFTLVHNGVI ENYVQLKQEYLQDVELKSDTDTEVVVQVIEQFVNGGLETEEAFRKTLTLLKGSYAIAL FDNDNRETIFVAKNKSPLLVGLGDTFNVVASDAMAMLQVTNEYVELMDKEMVIVTDDQ VVIKNLDGDVITRASYIAELDASDIEKGTYPHYMLKETDEQPVVMRKIIQTYQDENGK LSVPGDIAAAVAEADRIYIIGCGTSYHAGLVGKQYIEMWANVPVEVHVASEFSYNMPL LSKKPLFIFLSQSGETADSRAVLVQVKALGHKALTITNVPGSTLSREADYTLLLHAGP EIAVASTKAYTAQIAVLAVLASVAADKNGINIGFDLVKELGIAANAMEALCDQKDEME MIAREYLTVSRNAFFIGRGLDYFVCVEGALKLKEISYIQAEGFAGGELKHGTIALIEQ GTPVFALATQEHVNLSIRGNVKEVAARGANTCIISLKGLDDADDRFVLPEVNPALAPL VSVVPLQLIAYYAALHRGCDVDKPRNLAKSVTVE*" /label="glmS CDS" gene 199876..201678 /gene="glmS" /locus_tag="BSU_01780" /old_locus_tag="BSU01780" /label="glmS gene" S_feature complement(201401..>201681) /Source="Nicolas_S_feature" /locus_tag="new_201802_202546_c" /HighExp="S8, S7, S6, S5, S4, BC, S3, Sw, C30, LoTm" /AntisenseName="glmS" /AntisenseCor="4.5056549205256403E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.963" /TUlongSig="NA" /TUlongPSig="NA" /label="S70" downshifts 201664 /Source="Nicolas_upshifts" /id="D65" /incds=0 /nref=260 /ntot=277 /MaxReadThrough="3.18134" /MaxDrop="7.61794" /score="13.5044076" /energy="-17.5" /TU="NA" /idTUdmin="U122" /TUdmin=2 /isTUend="TRUE" /label="downshifts" SCAR join(201681,201727) /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="Delta4" N_region 201682..201726 /note="insertion of 45 bases of unknown origin" /modified_by="User" /label="Delta4" S_feature <201727..201845 /Source="Nicolas_S_feature" /locus_tag="new_220105_220278" /HighExp="LoTm, T5.0H, T4.0H, T3.30H, Pyr, T-2.40H, T3.0H, T-5.40H, S2, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.984" /TUlongSig="NA" /TUlongPSig="NA" /label="S79" CDS 201846..202823 /gene="ybdG" /locus_tag="BSU_01990" /old_locus_tag="BSU01990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase/transferase" /protein_id="NP_388081.2" /db_xref="EnsemblGenomes-Gn:BSU01990" /db_xref="EnsemblGenomes-Tr:CAB11993" /db_xref="GOA:O31431" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12722" /db_xref="UniProtKB/Swiss-Prot:O31431" /translation="MKTLWKVLKIVFVSLAALVLLVSVSVFIYHHFQLNKEAALLKGK GTVVDVDGKKMNVYQEGSGKDTFVFMSGSGIAAPAYEMKGLYSKFSKENKIAVVDRAG YGYSEVSHDDRDIDTVLEQTRKALMKSGNKPPYILMPHSISGIEAMYWAQKYPKEIKA IIAMDIGLPQQYVTYKLSGVDRLKVRGFHLLTSIGFHRFIPSAVYNPEVIRQSFLTDE EKEIYKAINFKQFFNADMEHELLQSYQNGSKSVNLPAPKETPVLILDAVSDQNRHSKY AIQNRKDYEAFAAQFNTADIKELRGTHSIYLYQPDQIYKLSMEFMRKVR*" /label="ybdG CDS" gene 201846..202823 /gene="ybdG" /locus_tag="BSU_01990" /old_locus_tag="BSU01990" /label="ybdG gene" CDS 202825..203496 /gene="ybdJ" /locus_tag="BSU_02000" /old_locus_tag="BSU02000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 20035725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 20035725; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component system response regulator [YbdK]" /protein_id="NP_388082.1" /db_xref="EnsemblGenomes-Gn:BSU02000" /db_xref="EnsemblGenomes-Tr:CAB11994" /db_xref="GOA:O31432" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12723" /db_xref="UniProtKB/Swiss-Prot:O31432" /translation="MKGYRILIVEDDVMIGDLLQKILQREGYRVIWKTDGADVLSVIQ KVDLVIMDVMLPGEDGYQMSAKIKKLGLGIPVIFLSARNDMDSKLQGLQIGEDYMVKP FDPRELLLRMRNMLEHHYGTFTQIKHLYIDAVTKKVFNESLHDEVLFTAIERKIFFYL YENRDSILTKEHFFEYLWQLEDRNPNIVNVHIKKIRAKINDQAGEMIENIYGEGYRLN TVVKK*" /label="ybdJ CDS" gene 202825..203496 /gene="ybdJ" /locus_tag="BSU_02000" /old_locus_tag="BSU02000" /label="ybdJ gene" promotor_-35 203390..203396 /Source="Nicolas_upshift_promotors" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 203410..203429 /Source="Nicolas_upshift_promotors" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 203428 /Source="Nicolas_upshifts" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="upshifts" CDS 203517..204479 /gene="ybdK" /locus_tag="BSU_02010" /old_locus_tag="BSU02010" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 20035725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 20035725; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component system sensor histidine kinase [YbdJ]" /protein_id="NP_388083.1" /db_xref="EnsemblGenomes-Gn:BSU02010" /db_xref="EnsemblGenomes-Tr:CAB11995" /db_xref="GOA:O31433" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12724" /db_xref="UniProtKB/Swiss-Prot:O31433" /translation="MLLFTAVISVPMLLLAVSVLMSVIYDSMFKPMNHGMPFHRSFAY PAMIVVFLISLLLLAFLFSKSIHSLLHKINLLNQTIRHLASDQRVPDKIEVKRADEIG ELIKSVNLLIERTTYRELELRQQEEIKKELLQKLRHDINTPLTALRLQLFYLEDQCHG QAVFESLYQQIEYISELTNEFNLYSAETLESSYIVNEEVRLNELLETAVKKWDYLYSM SGIELHYKPADQDVIWMSNTLWMERLFDNIFQNTLRHSKAKKMEVTIEHGDVFIRDDG IGFDRNESSEGLGLKIIEDTCRLLAITYELHTNDNGTGFLFSKE*" /label="ybdK CDS" gene 203517..204479 /gene="ybdK" /locus_tag="BSU_02010" /old_locus_tag="BSU02010" /label="ybdK gene" promotor_-35 204491..204493 /Source="Nicolas_upshift_promotors" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 204509..204528 /Source="Nicolas_upshift_promotors" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 204512 /Source="Nicolas_upshifts" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="upshifts" CDS 204538..204801 /gene="ybzI" /locus_tag="BSU_02019" /old_locus_tag="BSU02019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097672.1" /db_xref="EnsemblGenomes-Gn:BSU02019" /db_xref="EnsemblGenomes-Tr:CAX52542" /db_xref="UniProtKB/Swiss-Prot:C0H3T1" /translation="MNIICLKKSSKRLSTSQAVLVTDIADTGITAAAGADIIAATAAV RAKEDTTTVMAAVIVTNAGATAAVNPKKVLVPLLGQGFFYVTD*" /label="ybzI CDS" gene 204538..204801 /gene="ybzI" /locus_tag="BSU_02019" /old_locus_tag="BSU02019" /label="ybzI gene" downshifts 204742 /Source="Nicolas_upshifts" /id="D73" /incds=0 /nref=120 /ntot=235 /MaxReadThrough="2.82444" /MaxDrop="4.652" /score="22.3698707" /energy="-12.1" /TU="U135" /idTUdmin="U136" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(204786..205556) /gene="ybdM" /locus_tag="BSU_02030" /old_locus_tag="BSU02030" /EC_number="2.7.11.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21304896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative protein kinase" /protein_id="NP_388085.1" /db_xref="EnsemblGenomes-Gn:BSU02030" /db_xref="EnsemblGenomes-Tr:CAB11997" /db_xref="GOA:O31435" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG12726" /db_xref="UniProtKB/Swiss-Prot:O31435" /translation="MALKLLKKLLFDRPLKNGVILNHQYKIEECLGMGGYGLVYLCTD ILAQTPYVLKQLRPTKAKKEKEKVRFQQEIKLLKNIHHPQIPGFIDEFIIDGQAYYVM QFIEGENIEELLFFRKQPFTELMALQLISQLLEIIEYLHDRLIFHSDIRTPNIIINDG RLCLIDFGLAKQLTPEEMEEIKVRKQDDFFDLGETLLFLLYSQYKGKKKKNGTWLEEL TLTKEVTLLLKRLLGIEEEYQHTASIREDLNRAIQSVT*" /label="ybdM CDS" gene complement(204786..205556) /gene="ybdM" /locus_tag="BSU_02030" /old_locus_tag="BSU02030" /label="ybdM gene" CDS complement(205642..206499) /gene="ybdN" /locus_tag="BSU_02040" /old_locus_tag="BSU02040" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16794953; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; prophage region 1" /protein_id="NP_388086.1" /db_xref="EnsemblGenomes-Gn:BSU02040" /db_xref="EnsemblGenomes-Tr:CAB11998" /db_xref="SubtiList:BG12727" /db_xref="UniProtKB/Swiss-Prot:O31436" /translation="MVKKWLIQFAVMLSVLSTFTYSASAVGVTAITGNNSFDTAMPIG YWKYKNIDTTILEAGQDEAYFTFTANKGEKVYMRSTYQSAYTGMKIEIYDKNRIPVSQ GTEVINPNTFSSFIYANADAQNTTDTFYVKVSRGTYTGNMYFTLSIEDRIKSGSGTFQ FSGVAENKGNTSLSPSGSDSSVIKVDLTNQSGIPRDAIVTRVQTTATQTPSQGNTRHL IMTSENNEWSRALVNSSTSGSYDISLSDQLSVAKVWSFKYNTLATARSTMSNVKAKID YEYDVTKQF*" /label="ybdN CDS" gene complement(205642..206499) /gene="ybdN" /locus_tag="BSU_02040" /old_locus_tag="BSU02040" /label="ybdN gene" downshifts complement(205664) /Source="Nicolas_upshifts" /id="D74" /incds=0 /nref=95 /ntot=184 /MaxReadThrough="1.56932" /MaxDrop="4.95806" /score="36.4950689" /energy="-11.9" /TU="NA" /idTUdmin="U137" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(205713..205732) /Source="Nicolas_upshift_promotors" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(205746..205755) /Source="Nicolas_upshift_promotors" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(205748) /Source="Nicolas_upshifts" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(206512..206531) /Source="Nicolas_upshift_promotors" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(206537) /Source="Nicolas_upshifts" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(206546..206553) /Source="Nicolas_upshift_promotors" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 206567..206574 /Source="Nicolas_upshift_promotors" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="promotor_-35" promotor_-10 206588..206606 /Source="Nicolas_upshift_promotors" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="promotor_-10" upshifts 206590 /Source="Nicolas_upshifts" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="upshifts" CDS 206631..207815 /gene="ybdO" /locus_tag="BSU_02050" /old_locus_tag="BSU02050" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; prophage region 1" /protein_id="NP_388087.1" /db_xref="EnsemblGenomes-Gn:BSU02050" /db_xref="EnsemblGenomes-Tr:CAB11999" /db_xref="InterPro:IPR032617" /db_xref="SubtiList:BG12728" /db_xref="UniProtKB/Swiss-Prot:O31437" /translation="MRLNRQFIRTQLIAQNILSKNAPAKRENATENPAAVLEKAYSRL KSQSSTGGINQFNYSKTSVSGNSGTFSKVYQSANDRTVTDTGEETVIQSQNPYESESD IRIKILDEKYSRMNAINKTKSDPLGYIKDKYQNSKSPYFRSDLSAAERQAAYDNETEW LFKGKAQNYNLQDAVFRNVTFHGEVEAENEKVYQRGQVNQQLQVLLNRNHIHIPEGTE LTFTITPIDYQVRVSGTDDQDLIKQIEQVLQSGDNSKELFLHIMKSQSSDSAQFSEEA YKKYQAAREMYEVTGYHLKDLEVIDGRYVTPEGRDLMDVYKEELEKDPVQKQTASYAI SYYRSELSKIAEAGYNAIPDFILSIDYSNGSLRDVGQSKSYGTGDTGWLEALKRQTGV NY*" /label="ybdO CDS" gene 206631..207815 /gene="ybdO" /locus_tag="BSU_02050" /old_locus_tag="BSU02050" /label="ybdO gene" downshifts 207801 /Source="Nicolas_upshifts" /id="D75" /incds=0 /nref=107 /ntot=207 /MaxReadThrough="2.98334" /MaxDrop="4.9582" /score="-3.87053033" /energy="-8.3" /TU="U139" /idTUdmin="U139" /TUdmin="-181" /isTUend="FALSE" /label="downshifts" promotor_-35 207969..207975 /Source="Nicolas_upshift_promotors" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 207989..208008 /Source="Nicolas_upshift_promotors" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 208003..208132 /Source="Nicolas_S_feature" /locus_tag="new_226436_226565" /HighExp="Glu, LoTm, M9-stat, G135, GM-0.2, T-0.40H, Fru, UNK1, MG 120, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD" /TUlongPSig=1 /label="S80" upshifts 208003 /Source="Nicolas_upshifts" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="upshifts" CDS 208133..209521 /gene="ybxG" /locus_tag="BSU_02060" /old_locus_tag="BSU02060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_388088.1" /db_xref="EnsemblGenomes-Gn:BSU02060" /db_xref="EnsemblGenomes-Tr:CAB12000" /db_xref="GOA:P54425" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG11505" /db_xref="UniProtKB/Swiss-Prot:P54425" /translation="MANKELKRGLGARHIQMIALGGTIGVGLFMGSASTISWTGPSVL LAYAICGIFIFFIMRAMGEMLYVEPSTGSFATFGHQYIHPMAGYITAWSNWFQWIIVG MSEIIAVGSYTKYWFPDLPAWIPGIVAMVILGAANLISVKSFGEFEFWFAMIKIVTII LMIIAGIGIIFFGFGNGGDAIGLSNLWSHGGFFAGGFSGFFFALSLVIAAYQGVELIG ITAGEAKDPQNTLRNAIQSIIWRILIFYIGAIFVIVTVYPWDELNSLGSPFVSTFSKI GITAAAGIINFVVITAAMSGCNSGIFSAGRMLYTLGVNGQAPKFFKKISRNGVPLYGT IAVLIGLAVGVVLNYIAPPKIFVYVYSASVLPGMIPWFIILISHIGFRKAKGAALDKH PFKMPFAPFTNYLTIAFLLMVLVGMWFNDDTRISLIVGVIFLALVVISYYVFGIGKRT QANLTKSEQAAE*" /label="ybxG CDS" gene 208133..209521 /gene="ybxG" /locus_tag="BSU_02060" /old_locus_tag="BSU02060" /label="ybxG gene" downshifts 209529 /Source="Nicolas_upshifts" /id="D76" /incds=0 /nref=121 /ntot=219 /MaxReadThrough="2.32902" /MaxDrop="5.72049" /score="28.6554212" /energy="-8.5" /TU="NA" /idTUdmin="U140" /TUdmin="-15" /isTUend="TRUE" /label="downshifts" promotor_-35 209567..209573 /Source="Nicolas_upshift_promotors" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 209587..209598 /Source="Nicolas_upshift_promotors" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 209588 /Source="Nicolas_upshifts" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="upshifts" CDS 209633..209881 /gene="csgA" /locus_tag="BSU_02070" /old_locus_tag="BSU02070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9016963" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9016963; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific SASP protein" /protein_id="NP_388089.1" /db_xref="EnsemblGenomes-Gn:BSU02070" /db_xref="EnsemblGenomes-Tr:CAB12001" /db_xref="GOA:P54379" /db_xref="InterPro:IPR020255" /db_xref="SubtiList:BG11504" /db_xref="UniProtKB/Swiss-Prot:P54379" /translation="MDVTLGYLRESLSNHLENEVCQRICKKMLAKRYANEEEFVKDLD DNEMSFLNHVLEKEIKYAQNEQDQKRAKELNEVYELLL*" /label="csgA CDS" gene 209633..209881 /gene="csgA" /locus_tag="BSU_02070" /old_locus_tag="BSU02070" /label="csgA gene" CDS 209898..210089 /gene="ybxH" /locus_tag="BSU_02080" /old_locus_tag="BSU02080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388090.1" /db_xref="EnsemblGenomes-Gn:BSU02080" /db_xref="EnsemblGenomes-Tr:CAB12002" /db_xref="InterPro:IPR035314" /db_xref="SubtiList:BG11506" /db_xref="UniProtKB/Swiss-Prot:P54426" /translation="MGAIERSGYTFQPEFSVVRQNGAIHVYHQGEFVEEIEFEFNGEY PDHDLIEELVNHYCFEHEI*" /label="ybxH CDS" gene 209898..210089 /gene="ybxH" /locus_tag="BSU_02080" /old_locus_tag="BSU02080" /label="ybxH gene" downshifts 210071 /Source="Nicolas_upshifts" /id="D77" /incds=0 /nref=17 /ntot=40 /MaxReadThrough="0.194030000000001" /MaxDrop="4.779" /score="29.4617878" /energy="-15.6" /TU="NA" /idTUdmin="U141" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(210116..210919) /gene="ybxI" /locus_tag="BSU_02090" /old_locus_tag="BSU02090" /EC_number="3.5.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14742199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14742199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported beta-lactamase" /protein_id="NP_388091.1" /db_xref="EnsemblGenomes-Gn:BSU02090" /db_xref="EnsemblGenomes-Tr:CAB12003" /db_xref="GOA:P54427" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR002137" /db_xref="InterPro:IPR012338" /db_xref="PDB:5E2F" /db_xref="SubtiList:BG11507" /db_xref="UniProtKB/Swiss-Prot:P54427" /translation="MKKWIYVVLVLSIAGIGGFSVHAASSAHEKHLNVSKMNVDDEFK DTDGTFILHDLQKDQTFVYNRKRANQRQTPQSTFKVVNALIGLQVKAVRDEYDVKRWD GVKREFESWNRDHTLGSAMRESAIWYYQALARDIGEERMKTWLHTLSYGNEDISGGID QFWLQSSLTISPLEQETFLEKLAKEELPFDKPVMKIVKRMMIQEEGDHYTLYGKTGTR LTDMGLGWFVGFIKTEHGSYVFVTNVDDSGTKAKNITVDILKKYGLITS*" /label="ybxI CDS" gene complement(210116..210919) /gene="ybxI" /locus_tag="BSU_02090" /old_locus_tag="BSU02090" /label="ybxI gene" promotor_-10 complement(210941..210959) /Source="Nicolas_upshift_promotors" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(210949) /Source="Nicolas_upshifts" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(210970..210978) /Source="Nicolas_upshift_promotors" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 211033..211039 /Source="Nicolas_upshift_promotors" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 211054..211072 /Source="Nicolas_upshift_promotors" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 211060 /Source="Nicolas_upshifts" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="upshifts" CDS 211092..212345 /gene="cypC" /locus_tag="BSU_02100" /old_locus_tag="BSU02100" /EC_number="1.11.2.4" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10529095, 12519760, 21673922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10529095, 12519760, 21673922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid beta-hydroxylating cytochrome P450" /protein_id="NP_388092.1" /db_xref="EnsemblGenomes-Gn:BSU02100" /db_xref="EnsemblGenomes-Tr:CAB12004" /db_xref="GOA:O31440" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002401" /db_xref="InterPro:IPR036396" /db_xref="PDB:1IZO" /db_xref="PDB:2ZQJ" /db_xref="PDB:2ZQX" /db_xref="SubtiList:BG12729" /db_xref="UniProtKB/Swiss-Prot:O31440" /translation="MNEQIPHDKSLDNSLTLLKEGYLFIKNRTERYNSDLFQARLLGK NFICMTGAEAAKVFYDTDRFQRQNALPKRVQKSLFGVNAIQGMDGSAHIHRKMLFLSL MTPPHQKRLAELMTEEWKAAVTRWEKADEVVLFEEAKEILCRVACYWAGVPLKETEVK ERADDFIDMVDAFGAVGPRHWKGRRARPRAEEWIEVMIEDARAGLLKTTSGTALHEMA FHTQEDGSQLDSRMAAIELINVLRPIVAISYFLVFSALALHEHPKYKEWLRSGNSRER EMFVQEVRRYYPFGPFLGALVKKDFVWNNCEFKKGTSVLLDLYGTNHDPRLWDHPDEF RPERFAEREENLFDMIPQGGGHAEKGHRCPGEGITIEVMKASLDFLVHQIEYDVPEQS LHYSLARMPSLPESGFVMSGIRRKS*" /label="cypC CDS" gene 211092..212345 /gene="cypC" /locus_tag="BSU_02100" /old_locus_tag="BSU02100" /label="cypC gene" misc_feature 211404..211411 /Source="Nicolas_upshift_promotors" /id="U144" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.013986013986014" /xcortree=116 /SigmaFactorBS="atggcagcgcgcatatccatcggaagatgctttttctgtcat tgatgacaCCGCCGCAtcaaaaacgtttggctgagttgatgacagaggagtggaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 211414 /Source="Nicolas_upshifts" /id="U144" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.013986013986014" /xcortree=116 /SigmaFactorBS="atggcagcgcgcatatccatcggaagatgctttttctgtcat tgatgacaCCGCCGCAtcaaaaacgtttggctgagttgatgacagaggagtggaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 212338 /Source="Nicolas_upshifts" /id="D78" /incds=0 /nref=5 /ntot=36 /MaxReadThrough="2.65245" /MaxDrop="6.12325" /score="-7.42298703" /energy="-14.7" /TU="NA" /idTUdmin="U143" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(212386..212646) /gene="ybyB" /locus_tag="BSU_02110" /old_locus_tag="BSU02110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388093.1" /db_xref="EnsemblGenomes-Gn:BSU02110" /db_xref="EnsemblGenomes-Tr:CAB12005" /db_xref="SubtiList:BG12754" /db_xref="UniProtKB/Swiss-Prot:O31441" /translation="MKQKLLLSGLAVSTVGITSYLLKDPSNRQKAREFIHSMKMKITK QPDMETFPVDKAGHPDPQDIEDNKMVSEGSMYPVQYYDEKKK*" /label="ybyB CDS" gene complement(212386..212646) /gene="ybyB" /locus_tag="BSU_02110" /old_locus_tag="BSU02110" /label="ybyB gene" downshifts complement(212405) /Source="Nicolas_upshifts" /id="D79" /incds=0 /nref=155 /ntot=247 /MaxReadThrough="3.63752" /MaxDrop="7.83539" /score="8.86703843" /energy="-12.4" /TU="U145" /idTUdmin="U145" /TUdmin="-387" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(212676..212694) /Source="Nicolas_upshift_promotors" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(212685) /Source="Nicolas_upshifts" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(212708..212714) /Source="Nicolas_upshift_promotors" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 212838..212845 /Source="Nicolas_upshift_promotors" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 212855 /Source="Nicolas_upshifts" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 212861..212880 /Source="Nicolas_upshift_promotors" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 212915..214534 /gene="ybeC" /locus_tag="BSU_02120" /old_locus_tag="BSU02120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative H+/amino acid transporter" /protein_id="NP_388094.2" /db_xref="EnsemblGenomes-Gn:BSU02120" /db_xref="EnsemblGenomes-Tr:CAB12006" /db_xref="GOA:Q45577" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12730" /db_xref="UniProtKB/Swiss-Prot:Q45577" /translation="MNQLHRRMGTFSLMMVGLGSMIGSGWLFGAWRAAQIAGPAAIIS WVIGMVVILFIALSYSELGSMFPEAGGMVKYTQYSHGSFIGFIAGWANWIAIVSVIPV EAVASVQYMSSWPWEWAKWTSGLVKNGTLTGEGLAFASVLLLIYFLLNYWTVNLFSKA NSLITIFKIIIPGLTIGALLFVGFHGENFTGGQSIAPNGWASVLTAVATSGIVFAFNG FQSPINMAGEAKNPGKSIPIAVVGSLFVATVIYVLLQIAFIGAVNPSDIAHGWSHLNF NSPFADLAIALNINWLVIVLYADAFVSPSGTGITYTATTSRMIYGMEKNKYMPSIFGK LHPIYGVPRQAMFFNLIVSFIFLFLFRGWGVLAEIISVATLISYITGPITVMTLRRTG KDLYRPLRLKGLNVIAPLGFIFASLVLYWARWPLTGQVLFIILIGLPIYFYYQAKAKW KGFGRNFKAGVWMVFYLLAMMVISYLGSDKFGGLNVIHYGWDMVLIAMVSLVFYVWAL KSGYQTEYLKDAKEINSQLLNGQSEAAAGKE*" /label="ybeC CDS" gene 212915..214534 /gene="ybeC" /locus_tag="BSU_02120" /old_locus_tag="BSU02120" /label="ybeC gene" downshifts 214517 /Source="Nicolas_upshifts" /id="D80" /incds=0 /nref=183 /ntot=273 /MaxReadThrough="0.8051" /MaxDrop="6.79949" /score="24.7668372" /energy="-12.2" /TU="NA" /idTUdmin="U146" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(214581..215462) /gene="glpQA" /locus_tag="BSU_02130" /old_locus_tag="BSU02130" /EC_number="3.1.4.46" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10913081, 21966272" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 21966272; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted glycerophosphoryl diester phosphodiesterase" /protein_id="NP_388095.1" /db_xref="EnsemblGenomes-Gn:BSU02130" /db_xref="EnsemblGenomes-Tr:CAB12007" /db_xref="GOA:P37965" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="PDB:5T91" /db_xref="PDB:5T9B" /db_xref="PDB:5T9C" /db_xref="SubtiList:BG10646" /db_xref="UniProtKB/Swiss-Prot:P37965" /translation="MRKNRILALFVLSLGLLSFMVTPVSAASKGNLLSPDRILTVAHR GASGYVPEHTILSYETAQKMKADFIELDLQMTKDGKLIVMHDEKLDRTTNGMGWVKDH TLADIKKLDAGSWFNEAYPEKAKPQYVGLKVPTLEEVLDRFGKHANYYIETKSPDTYP GMEEKLIASLQKHKLLGKHSKPGQVIIQSFSKESLVKVHQLQPNLPTVQLLEAKQMAS MTDAALEEIKTYAVGAGPDYKALNQENVRMIRSHGLLLHPYTVNNEADMHRLLDWGVT GVFTNYPDLFHKVKKGY*" /label="glpQA CDS" gene complement(214581..215462) /gene="glpQA" /locus_tag="BSU_02130" /old_locus_tag="BSU02130" /label="glpQA gene" downshifts complement(214592) /Source="Nicolas_upshifts" /id="D81" /incds=0 /nref=61 /ntot=107 /MaxReadThrough="2.31368" /MaxDrop="7.76277" /score="9.56390732" /energy="-11.4" /TU="NA" /idTUdmin="U147" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(215505) /Source="Nicolas_upshifts" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(215514..215530) /Source="Nicolas_upshift_promotors" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(215539..215545) /Source="Nicolas_upshift_promotors" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(215561..216895) /gene="glpT" /locus_tag="BSU_02140" /old_locus_tag="BSU02140" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8012593, 11929549, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8012593, 11929549, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate permease" /protein_id="NP_388096.1" /db_xref="EnsemblGenomes-Gn:BSU02140" /db_xref="EnsemblGenomes-Tr:CAB12008" /db_xref="GOA:P37948" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR005267" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR021159" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10645" /db_xref="UniProtKB/Swiss-Prot:P37948" /translation="MLNIFKPAPHIERLDDSKMDAAYKRLRLQVFIGIFIGYAGYYLL RKNFAFAIPYLQEQGFSKTELGLVLAAVSIAYGFSKFIMGMVSDRCNPRYFLATGLFL SAIVNILFVSMPWVTSSVTIMFIFMFINGWFQGMGWPPCGRTMAHWFSISERGTKMSI WNVAHNIGGGILAPLVTLGIAMFVTWKSVFFFPAIIAIIISFLIVLLVRDTPQSCGLP PIEEYRNDYPKHAFKNQEKELTTKEILFQYVLNNKFLWYIAFANVFVYFVRYGVVDWA PTYLTEAKGFSPEDSRWSYFLYEYAGIPGTILCGWISDRFFKSRRAPAGVLFMAGVFI AVLVYWLNPAGNPLVDNIALISIGFLIYGPVMLIGLQAIDLAPKKAAGTAAGLTGFFG YIGGSAFANAIMGFVVDRFNWNGGFIMLISSCILAIVFLALTWNTGKRAEHV*" /label="glpT CDS" gene complement(215561..216895) /gene="glpT" /locus_tag="BSU_02140" /old_locus_tag="BSU02140" /label="glpT gene" promotor_-35 216543..216552 /Source="Nicolas_upshift_promotors" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 216565..217191 /Source="Nicolas_S_feature" /locus_tag="new_234998_235624" /HighExp="S6, S8, S7, S5, BT, B36, G/S, C30, Pyr, B60" /AntisenseName="glpT" /AntisenseCor="-5.0958691169636701E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S81" promotor_-10 216565..216584 /Source="Nicolas_upshift_promotors" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 216565 /Source="Nicolas_upshifts" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(216896..216968) /Source="Nicolas_S_feature" /locus_tag="new_235329_235401_c" /HighExp="G150, Oxctl, Paraq, S0, Diami, H2O2, Lbexp, dia5, dia0, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.042, 0.935" /TUlongSig="NA" /TUlongPSig="NA" /label="S82" promotor_no_box complement(216928..217028) /Source="Nicolas_upshift_promotors" /id="U149" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.370629370629371" /psig="0.041958041958042" /xcortree=1566 /SigmaFactorBS="tagcttggatggagatgaggagagccaggaatccaacccctt ttgacaaggggtgttttctggctctttttgtttttcgggaaaggaggcacgccacaca t" /listShort="S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(216968) /Source="Nicolas_upshifts" /id="U149" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.370629370629371" /psig="0.041958041958042" /xcortree=1566 /SigmaFactorBS="tagcttggatggagatgaggagagccaggaatccaacccctt ttgacaaggggtgttttctggctctttttgtttttcgggaaaggaggcacgccacaca t" /listShort="S82, glpT, glpQ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(216970..217056) /Source="Nicolas_S_feature" /locus_tag="new_235403_235489_c" /HighExp="G150, Oxctl, S0, Diami, Lbexp, dia5, Paraq, dia0, T0.30H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.935" /TUlongSig="NA" /TUlongPSig="NA" /label="S83" promotor_-10 complement(217046..217065) /Source="Nicolas_upshift_promotors" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(217060) /Source="Nicolas_upshifts" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(217078..217085) /Source="Nicolas_upshift_promotors" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 217192..217440 /gene="ybeF" /locus_tag="BSU_02150" /old_locus_tag="BSU02150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388097.1" /db_xref="EnsemblGenomes-Gn:BSU02150" /db_xref="EnsemblGenomes-Tr:CAB12009" /db_xref="GOA:O31442" /db_xref="InterPro:IPR020258" /db_xref="SubtiList:BG12731" /db_xref="UniProtKB/Swiss-Prot:O31442" /translation="MDELDIAFFILPLGIMLLSIVGTCICKNPYLMPMLSLVISLVLT FTIFNQSFLGWAVVYSLVSLALSYITLIVVRKRKESGN*" /label="ybeF CDS" gene 217192..217440 /gene="ybeF" /locus_tag="BSU_02150" /old_locus_tag="BSU02150" /label="ybeF gene" promotor_-35 217464..217471 /Source="Nicolas_upshift_promotors" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 217471 /Source="Nicolas_upshifts" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 217487..217506 /Source="Nicolas_upshift_promotors" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 217532..218449 /gene="ybfA" /locus_tag="BSU_02160" /old_locus_tag="BSU02160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator with acetyltransferase domain" /protein_id="NP_388098.1" /db_xref="EnsemblGenomes-Gn:BSU02160" /db_xref="EnsemblGenomes-Tr:CAB12010" /db_xref="GOA:O31443" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12732" /db_xref="UniProtKB/Swiss-Prot:O31443" /translation="MKTRESSVGLKFRKFNRFYTNVLGFLNEHIYDSPFSLTETRILF EIYNTPNCTAKALQDKLGLDRGYVSRIVKQFEKEDLIYKQRSKDDARHHYIFVTETGK TIYKKLEEKANEQVELMLKVINQKEQHKLAEAMAEIEAILSQSLSARASEISIRDYFL SEDLQLLIEKQRQFYAEAHGWDDTFLAYLQETFDADIEKIWIAESGGKFAGSVGLVKH DEKTVQLRWFLVDADFRGRGLGTQLLEHLVAYCQDMKFDRIFLWTVSTMAEARPLYKK FGFRISEVKQEAPLWGQQLTEERWDLELS*" /label="ybfA CDS" gene 217532..218449 /gene="ybfA" /locus_tag="BSU_02160" /old_locus_tag="BSU02160" /label="ybfA gene" CDS 218446..219696 /gene="ybfB" /locus_tag="BSU_02170" /old_locus_tag="BSU02170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative carboxylate transporter" /protein_id="NP_388099.1" /db_xref="EnsemblGenomes-Gn:BSU02170" /db_xref="EnsemblGenomes-Tr:CAB12011" /db_xref="GOA:O31444" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12733" /db_xref="UniProtKB/Swiss-Prot:O31444" /translation="MKRLHYAWIIVSVTFLILLAVQGVRLSFGAFVEPWERQFSIDRS TISLISTVSFIVYGISQPVIGRLVDKWGARAVLAWSALLTGVSIFLTYLVTSPWQLFL LYGLGVSLGVGGASNVAASVLVVNWFSKKRGLAFGIMEAGFGAGQMLLVPGSLMLIHW FSWKLTVVVLGLLLIVIVFPAALLMLRNNPSEKNTEPIGGLAASEKETAPKTTALSVA GMFRMRQFWFLIFPFLICGFTTVGLMDTHLIPFSHDHGFSTTVTSAAVSLLAGFNIAG ILLSGIVADRWSSRKILCILYAVRALSIVILIYSHEPYLLLAFAILFGLVDFATVAPT QMLATQYFQNYSIGLMIGWLSLAHQIGSALGAYVPGVIYTVTGEYTLAFYLSIGMLVL ASVMNVMLREPAAVTRDSAAVVDK*" /label="ybfB CDS" gene 218446..219696 /gene="ybfB" /locus_tag="BSU_02170" /old_locus_tag="BSU02170" /label="ybfB gene" downshifts 219686 /Source="Nicolas_upshifts" /id="D82" /incds=0 /nref=57 /ntot=187 /MaxReadThrough="1.17226" /MaxDrop="5.55429" /score="12.1347284" /energy="-9.5" /TU="NA" /idTUdmin="U151" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(219731..220015) /gene="ybfEc" /locus_tag="BSU_02180" /old_locus_tag="BSU02180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (C-terminal end)" /db_xref="EnsemblGenomes-Gn:BSU02180" /db_xref="EnsemblGenomes-Tr:CAB12012" /db_xref="GOA:O31445" /db_xref="PSEUDO:CAB12012.2" /db_xref="SubtiList:BG12734" /db_xref="UniProtKB/Swiss-Prot:O31445" /translation="MNHCLHSNTLAKIVCTVTLITLYFYFFSTRFNELIELAVQMFFA LIGLFWVFIVSPFSRKVQISERFKQKSENARIVGMIDFVLEQKYKKSISE*" /label="ybfEc CDS" gene complement(219731..220015) /gene="ybfEc" /locus_tag="BSU_02180" /old_locus_tag="BSU02180" /pseudo /label="ybfEc gene" downshifts complement(219784) /Source="Nicolas_upshifts" /id="D83" /incds=0 /nref=4 /ntot=189 /MaxReadThrough="2.49989" /MaxDrop="3.7302" /score="13.7144473" /energy="-12.6" /TU="U153" /idTUdmin="U153" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(219921..220043) /gene="ybfEn" /locus_tag="BSU_02181" /old_locus_tag="BSU02181" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function YbfE (N-terminal fragment)" /db_xref="PSEUDO:SOX90538.1" /translation="MLNQLKVFFSEPLLTFKHTCQNRMYCDINNVILLFFQHSF*" /label="ybfEn CDS" gene complement(219921..220043) /gene="ybfEn" /locus_tag="BSU_02181" /old_locus_tag="BSU02181" /pseudo /label="ybfEn gene" S_feature complement(220016..220136) /Source="Nicolas_S_feature" /locus_tag="new_238449_238569_c" /HighExp="Lbexp, dia0, LBGexp, G150, Mt0, H2O2, dia5, M0t45, G135, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, Sig-" /TUshortPSig="0.899, 0" /TUlongSig="NA" /TUlongPSig="NA" /label="S84" promotor_-10 complement(220121..220139) /Source="Nicolas_upshift_promotors" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(220136) /Source="Nicolas_upshifts" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(220138..220210) /Source="Nicolas_S_feature" /locus_tag="new_238571_238643_c" /HighExp="Lbexp, dia0, LBGexp, HPh, G150, H2O2, dia5, Mt0, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig=0 /TUlongSig="NA" /TUlongPSig="NA" /label="S85" promotor_-35 complement(220156..220161) /Source="Nicolas_upshift_promotors" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(220211..221122) /gene="ybfF" /locus_tag="BSU_02190" /old_locus_tag="BSU02190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388101.1" /db_xref="EnsemblGenomes-Gn:BSU02190" /db_xref="EnsemblGenomes-Tr:CAB12013" /db_xref="GOA:O31446" /db_xref="SubtiList:BG12735" /db_xref="UniProtKB/Swiss-Prot:O31446" /translation="MKNDQIVFEKTKNIAHDINQMQNQQEIIDYLFRQDSLTLNQLKH YYSEPSLPLQFLVKVAVLCMFISMTLASFLFIQAKEVFTNTILSDISPAVFSIFTVIC IFMTYTKIIKKGNKNKGKASLNQRSEFYEKNKLINTILYKKYKMDQQNIQANKHTASD NEDSMNFSAVLNHVLTISKNDKELLGYLDTRDNAMLSQLKAYFSTRPFSLPHYMSLMF CGSIIVVYATSLFSGQINYIDIPHIFIFLLLIIFLKILIDLIKLLNISRKGQLHTVLH FAQRAEYLRMRGVIDFILTERYNKKIM*" /label="ybfF CDS" gene complement(220211..221122) /gene="ybfF" /locus_tag="BSU_02190" /old_locus_tag="BSU02190" /label="ybfF gene" S_feature complement(221123..221210) /Source="Nicolas_S_feature" /locus_tag="new_239556_239643_c" /HighExp="LBGexp, Lbexp, G150, dia5, dia0, G135, Oxctl, H2O2, Mt0, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig=0 /TUlongSig="NA" /TUlongPSig="NA" /label="S86" CDS complement(221211..223409) /gene="ybfG" /locus_tag="BSU_02200" /old_locus_tag="BSU02200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pepdidoglycan binding protein" /protein_id="NP_388102.1" /db_xref="EnsemblGenomes-Gn:BSU02200" /db_xref="EnsemblGenomes-Tr:CAB12014" /db_xref="GOA:O31447" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR015020" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG12736" /db_xref="UniProtKB/Swiss-Prot:O31447" /translation="MVDEMVLITQQWLNDTYSGKHGYNPVEESGKTGWDTIYGLTRAL QIELGISEPADNFGPTTQRLFKPLKRQAPDSKPSNMNFILQGALWCKGFNPGGFTGVF YEKTENAVKEFQKAAGLTTQDGIVTTLIMKALLDMSAFKLVSGGDSRIRQIQQNLNRD YNDYIGLMPCDGLYGRDTNKALIYALQKEEGMSTSVANGFFGNGTTSLCPTLTPGDSR TGFVLIVQYALYCNGKSFDPGEFDGKYGVGVVSAVKAFQEFMCLPQTGYADMPTIKAL LSSSGDTTRTASACDTATIITAEKAQTLRNNGYKTVGRYLTGNVRTSSGLTSKALTSK ELAVILDAGLKVFPIYQDGGYESSYFVKDQGTRDAYSAASAARRLGFPSGTTIYFAVD FDAYDYEVTDKIIPYFQEIKSAFTKMQTFSTAPKYEIGVYGPRNICIRTSEAGLTKYS FVANMSTGFSGNLGYPMPNNWAFDQFYEGTIGSGSGSIGIDKDGYSGRDSGASNVNPP SDPVYDARLRTLTDILSTIPALENLTSLANAMFEFDTTETIFTSPELDIILSTSLLAT IPSEGSPNTITITNGKPGAYITGLLGDTQTSLTASQIDSYQNLLNSLSLSVRNGYLEV YVNPTAESLNIQIKIYTPDIPVGDNVTTGLTTTITFKIKTYKGVPVTSPESELALDWP SYDQYLFPVVGVAALLLIGNMGSDLTNNKGVKVATALSAMLLAIFAYYTS*" /label="ybfG CDS" gene complement(221211..223409) /gene="ybfG" /locus_tag="BSU_02200" /old_locus_tag="BSU02200" /label="ybfG gene" misc_feature complement(223444..223462) /Source="Nicolas_upshift_promotors" /id="U153" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1523 /SigmaFactorBS="ctgttggagaacggatgtaaaatggatgcttaacggcatcca tttttttattttGTCCTACGTTTGCCACCTAtaaatgaacgcaatctaacaaaggagg a" /listShort="ybfG, S86, ybfF, S85, S84, ybfE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(223456) /Source="Nicolas_upshifts" /id="U153" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1523 /SigmaFactorBS="ctgttggagaacggatgtaaaatggatgcttaacggcatcca tttttttattttGTCCTACGTTTGCCACCTAtaaatgaacgcaatctaacaaaggagg a" /listShort="ybfG, S86, ybfF, S85, S84, ybfE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(223484..224404) /gene="ybfH" /locus_tag="BSU_02210" /old_locus_tag="BSU02210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388103.1" /db_xref="EnsemblGenomes-Gn:BSU02210" /db_xref="EnsemblGenomes-Tr:CAB12015" /db_xref="GOA:O31448" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12737" /db_xref="UniProtKB/Swiss-Prot:O31448" /translation="MNIQRETSGHIAAIVTILIWGTTFISTKVLLADFSPMEILFYRF LMGFIALILVRPNMIPFRNWRQELLFAGAGLFGVTLYFLLENIALTYTYASNVGMIVS IIPMITAVLAHFLLEGEKLRLTFLIGFISALIGLLLITFNGNVVLRLNPLGDIMAAGA ALVFGGYSIFMKKLSAYEYHIIELTQRVFLYGLLFMVPALFLFDFHFDLSRFSSASNI LNMLFLGIGASALCFATWNYSVGVLGAVKSSAYIYMVPVITIAASVLILHENMTWIAL LGGALTLLGLYISELKPKAKLLENGCKMDA*" /label="ybfH CDS" gene complement(223484..224404) /gene="ybfH" /locus_tag="BSU_02210" /old_locus_tag="BSU02210" /label="ybfH gene" CDS complement(224401..225228) /gene="ybfI" /locus_tag="BSU_02220" /old_locus_tag="BSU02220" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family, cupin family)" /protein_id="NP_388104.1" /db_xref="EnsemblGenomes-Gn:BSU02220" /db_xref="EnsemblGenomes-Tr:CAB12016" /db_xref="GOA:O31449" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12738" /db_xref="UniProtKB/Swiss-Prot:O31449" /translation="MQNETRTLQLDPHLHIEAYRFKGIMQKFPNHFHDYYVIGFIEKG QRYLACQDQEYIINPGDLLLFNPRDTHSCEQIDGRTLDYRCINVMPDIMEKAVKEITG SGHLPYFSQHVLFRHELTASLQELHILISEEKQALRKEELFLHLLEELIRHYSDVTFL SSVPEPSDEVKMVCEFLEEHYAENVTLNDLSELTGWSKYHLLRSFTKQKGITPNSYME TIRINQAKKLLEQGVRPIDAAFQTGFSDQSHMTKFFKRQVGLTPKQYMKIFEKELHR* " /label="ybfI CDS" gene complement(224401..225228) /gene="ybfI" /locus_tag="BSU_02220" /old_locus_tag="BSU02220" /label="ybfI gene" misc_feature complement(225255..225274) /Source="Nicolas_upshift_promotors" /id="U154" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=583 /SigmaFactorBS="ctttctctattcctaaacagcaacatcatacaagaaatcccc caaaatCATGCTACACTTAATCCAAGaccaccacaccgacaggaggcatcccatgcaa a" /listShort="ybfI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(225262) /Source="Nicolas_upshifts" /id="U154" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=583 /SigmaFactorBS="ctttctctattcctaaacagcaacatcatacaagaaatcccc caaaatCATGCTACACTTAATCCAAGaccaccacaccgacaggaggcatcccatgcaa a" /listShort="ybfI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 225402..225405 /Source="Nicolas_upshift_promotors" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 225420..225439 /Source="Nicolas_upshift_promotors" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 225425 /Source="Nicolas_upshifts" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="upshifts" CDS 225459..226613 /gene="purT" /locus_tag="BSU_02230" /old_locus_tag="BSU02230" /EC_number="2.1.2.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7496533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7496533; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide formyltransferase 2" /protein_id="NP_388105.1" /db_xref="EnsemblGenomes-Gn:BSU02230" /db_xref="EnsemblGenomes-Tr:CAB12017" /db_xref="GOA:P39771" /db_xref="InterPro:IPR003135" /db_xref="InterPro:IPR005862" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG10924" /db_xref="UniProtKB/Swiss-Prot:P39771" /translation="MYQSKKVLLLGSGELGKEVVIEAQRLGVQTVAVDSYEHAPAMQV AHNSYVVDMLDPEQIRTIIEKENPDLIVPEVEAIATDELLKLEEEGFHVIPNARAAKL TMDREGIRRLAAETLGLATAGYEFANTYDEFIQAAAQIGFPCVVKPLMSSSGKGQSVC RSEADLESCWETAMEGGRVKNGRVIVEEFIPFESEITLLTVRAVNGTAFCEPIGHVQK DGDYIESWQPHDMTEQQIEEAKHIAKTITDELGGYGLFGVELFLAKDRVYFSEVSPRP HDTGLVTLVTQNLSEFALHVRAILGFPITEITQLSPGASRPLKAPEELADYTVEGLEN ALAVPKTQVRVFGKPITKAGRRMAVALSAADSVETARENAKKALDQLILK*" /label="purT CDS" gene 225459..226613 /gene="purT" /locus_tag="BSU_02230" /old_locus_tag="BSU02230" /label="purT gene" downshifts 226594 /Source="Nicolas_upshifts" /id="D84" /incds=0 /nref=100 /ntot=189 /MaxReadThrough="2.6996" /MaxDrop="5.22319" /score="39.2561117" /energy="-15.1" /TU="NA" /idTUdmin="U155" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 226674..226679 /Source="Nicolas_upshift_promotors" /id="U156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1104 /SigmaFactorBS="ttgtcatgggacaaggcctgtttttttctttctccgtaaaag ttttATCATAagaatcagaaacctGATTATAATGTAAAAGTCTtccatcgatacgggt g" /listShort="mpr, ybfJ" /listLong="S87, ybfK, S88, pssA, ybfM, psd" /label="promotor_-35" upshifts 226688 /Source="Nicolas_upshifts" /id="U156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1104 /SigmaFactorBS="ttgtcatgggacaaggcctgtttttttctttctccgtaaaag ttttATCATAagaatcagaaacctGATTATAATGTAAAAGTCTtccatcgatacgggt g" /listShort="mpr, ybfJ" /listLong="S87, ybfK, S88, pssA, ybfM, psd" /label="upshifts" promotor_-10 226694..226712 /Source="Nicolas_upshift_promotors" /id="U156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1104 /SigmaFactorBS="ttgtcatgggacaaggcctgtttttttctttctccgtaaaag ttttATCATAagaatcagaaacctGATTATAATGTAAAAGTCTtccatcgatacgggt g" /listShort="mpr, ybfJ" /listLong="S87, ybfK, S88, pssA, ybfM, psd" /label="promotor_-10" promotor_-35 226728..226735 /Source="Nicolas_upshift_promotors" /id="U157" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig=1 /xcortree=760 /SigmaFactorBS="acctgattataatgtaaaagtcttccatcgatacgggtGGTT GACActaaaggagggagaTGACAAAATGAAATTAGTTCcaagattcagaaaacaatgg t" /listShort="mpr, ybfJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 226750..226769 /Source="Nicolas_upshift_promotors" /id="U157" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig=1 /xcortree=760 /SigmaFactorBS="acctgattataatgtaaaagtcttccatcgatacgggtGGTT GACActaaaggagggagaTGACAAAATGAAATTAGTTCcaagattcagaaaacaatgg t" /listShort="mpr, ybfJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 226750 /Source="Nicolas_upshifts" /id="U157" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig=1 /xcortree=760 /SigmaFactorBS="acctgattataatgtaaaagtcttccatcgatacgggtGGTT GACActaaaggagggagaTGACAAAATGAAATTAGTTCcaagattcagaaaacaatgg t" /listShort="mpr, ybfJ" /GFF_Attribute="listLong" /label="upshifts" CDS 226757..227698 /gene="mpr" /locus_tag="BSU_02240" /old_locus_tag="BSU02240" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15205417, 15375126, 21819557, 25666135; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular glutamyl-endopeptidase" /protein_id="NP_388106.1" /db_xref="EnsemblGenomes-Gn:BSU02240" /db_xref="EnsemblGenomes-Tr:CAB12018" /db_xref="GOA:P39790" /db_xref="InterPro:IPR000126" /db_xref="InterPro:IPR001254" /db_xref="InterPro:IPR008256" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR018114" /db_xref="InterPro:IPR028301" /db_xref="SubtiList:BG10690" /db_xref="UniProtKB/Swiss-Prot:P39790" /translation="MKLVPRFRKQWFAYLTVLCLALAAAVSFGVPAKAAENPQTSVSN TGKEADATKNQTSKADQVSAPYEGTGKTSKSLYGGQTELEKNIQTLQPSSIIGTDERT RISSTTSFPYRATVQLSIKYPNTSSTYGCTGFLVNPNTVVTAGHCVYSQDHGWASTIT AAPGRNGSSYPYGTYSGTMFYSVKGWTESKDTNYDYGAIKLNGSPGNTVGWYGYRTTN SSSPVGLSSSVTGFPCDKTFGTMWSDTKPIRSAETYKLTYTTDTYGCQSGSPVYRNYS DTGQTAIAIHTNGGSSYNLGTRVTNDVFNNIQYWANQ*" /label="mpr CDS" gene 226757..227698 /gene="mpr" /locus_tag="BSU_02240" /old_locus_tag="BSU02240" /label="mpr gene" CDS 227661..228059 /gene="ybfJ" /locus_tag="BSU_02250" /old_locus_tag="BSU02250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388107.1" /db_xref="EnsemblGenomes-Gn:BSU02250" /db_xref="EnsemblGenomes-Tr:CAB12019" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR019730" /db_xref="SubtiList:BG12739" /db_xref="UniProtKB/Swiss-Prot:O31451" /translation="MYSTIFNIGQINKYSKLAIFMSILFLCGCSSQTHSSQKETTIPV TLHVEDAKGLPVEGVQVTIVKAPSSDEEPSTEIGEILGKTDKNGDIKWDTGRKGDYSV ALTKGETSVTHHISLTEDKKDHAIPLVFKE*" /label="ybfJ CDS" gene 227661..228059 /gene="ybfJ" /locus_tag="BSU_02250" /old_locus_tag="BSU02250" /label="ybfJ gene" promotor_-10 complement(227753..227767) /Source="Nicolas_upshift_promotors" /id="U158" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=776 /SigmaFactorBS="gcagccccttagcatcctccacatgaagagtgacaGGAATAg tcgtttctttttgaGAAGAATGCGTCTGCgaactgcacccgcataaaaacaaaataga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(227763) /Source="Nicolas_upshifts" /id="U158" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=776 /SigmaFactorBS="gcagccccttagcatcctccacatgaagagtgacaGGAATAg tcgtttctttttgaGAAGAATGCGTCTGCgaactgcacccgcataaaaacaaaataga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(227783..227788) /Source="Nicolas_upshift_promotors" /id="U158" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=776 /SigmaFactorBS="gcagccccttagcatcctccacatgaagagtgacaGGAATAg tcgtttctttttgaGAAGAATGCGTCTGCgaactgcacccgcataaaaacaaaataga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 228046 /Source="Nicolas_upshifts" /id="D85" /incds=0 /nref=19 /ntot=51 /MaxReadThrough="3.50775" /MaxDrop="5.06025" /score="29.4582027" /energy="-15.4" /TU="U156" /idTUdmin="U157" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 228115..228122 /Source="Nicolas_upshift_promotors" /id="U159" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=2185 /SigmaFactorBS="ttttatttattgcaggaaaccaaacTATATACTggaaattta ttatgTGAGATAATAAGAAATAGGTattttttcttacgagacaaaaggggcgttatcc t" /listShort="S87, ybfK, S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 228137..228156 /Source="Nicolas_upshift_promotors" /id="U159" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=2185 /SigmaFactorBS="ttttatttattgcaggaaaccaaacTATATACTggaaattta ttatgTGAGATAATAAGAAATAGGTattttttcttacgagacaaaaggggcgttatcc t" /listShort="S87, ybfK, S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 228150..228224 /Source="Nicolas_S_feature" /locus_tag="new_246583_246657" /HighExp="Cold, LoTm, S0, aero, ferm, T-4.40H, nit, T-5.40H, T-0.40H, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.973" /label="S87" upshifts 228150 /Source="Nicolas_upshifts" /id="U159" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=2185 /SigmaFactorBS="ttttatttattgcaggaaaccaaacTATATACTggaaattta ttatgTGAGATAATAAGAAATAGGTattttttcttacgagacaaaaggggcgttatcc t" /listShort="S87, ybfK, S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="upshifts" CDS 228225..229115 /gene="cesB" /locus_tag="BSU_02260" /old_locus_tag="BSU02260" /EC_number="3.1.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11389736, 24418394" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11389736, 24418394; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enantioselective carboxylesterase" /protein_id="NP_388108.1" /db_xref="EnsemblGenomes-Gn:BSU02260" /db_xref="EnsemblGenomes-Tr:CAB12020" /db_xref="GOA:O31452" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="PDB:4CCY" /db_xref="SubtiList:BG12740" /db_xref="UniProtKB/Swiss-Prot:O31452" /translation="MIQDSMQFAAVESGLRFYQAYDQSLSLWPIESEAFYVSTRFGKT HIIASGPKDAPSLILLHGGLFSSAMWYPNIAAWSSQFRTYAVDIIGDKNKSIPSAAME TRADFAEWMKDVFDSLGLETAHLAGLSLGGSHIVNFLLRAPERVERAVVISPAEAFIS FHPDVYKYAAELTGARGAESYIKWITGDSYDLHPLLQRQIVAGVEWQDEQRSLKPTEN GFPYVFTDQELKSIQVPVLLMFGEHEAMYHQQMAFERASVLVPGIQAEIVKNAGHLLS LEQPEYVNQRVLSFLCGGIK*" /label="cesB CDS" gene 228225..229115 /gene="cesB" /locus_tag="BSU_02260" /old_locus_tag="BSU02260" /label="cesB gene" promotor_-35 228459..228466 /Source="Nicolas_upshift_promotors" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 228475 /Source="Nicolas_upshifts" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 228480..228498 /Source="Nicolas_upshift_promotors" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 229116..229310 /Source="Nicolas_S_feature" /locus_tag="new_247549_247743" /HighExp="Cold, LBGstat, Paraq, Oxctl, H2O2, dia15, G135, Diami, Lbexp, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="0.867, 1" /TUlongSig="SigEF" /TUlongPSig="0.973" /label="S88" CDS 229311..229844 /gene="pssA" /locus_tag="BSU_02270" /old_locus_tag="BSU02270" /EC_number="2.7.8.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762009, 15743965, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762009, 15743965, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylserine synthase" /protein_id="NP_388109.1" /db_xref="EnsemblGenomes-Gn:BSU02270" /db_xref="EnsemblGenomes-Tr:CAB12021" /db_xref="GOA:P39823" /db_xref="InterPro:IPR000462" /db_xref="InterPro:IPR004533" /db_xref="SubtiList:BG11012" /db_xref="UniProtKB/Swiss-Prot:P39823" /translation="MNYIPCMITIGNFICGLLAIHSLLYHNIHSAVLFIFTGMFLDFF DGMAARKLNAVSDMGRELDSFADLVTFGVAPSMLAYSVALYTLPFIGILCALTYSICG MLRLSKFNIEQSKLPTFIGMPIPFAGMCLVILSFTYNPILLAIGTCGLSYLMVSKIKF PHFKKHAAENLESGRWN*" /label="pssA CDS" gene 229311..229844 /gene="pssA" /locus_tag="BSU_02270" /old_locus_tag="BSU02270" /label="pssA gene" CDS 229835..230323 /gene="ybfM" /locus_tag="BSU_02280" /old_locus_tag="BSU02280" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 14762009, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane phosphatase" /protein_id="NP_388110.1" /db_xref="EnsemblGenomes-Gn:BSU02280" /db_xref="EnsemblGenomes-Tr:CAB12022" /db_xref="GOA:O31453" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG12741" /db_xref="UniProtKB/Swiss-Prot:O31453" /translation="MELVQQLIADYGYLAIFLMLVLGIVGLPIPDEVMMTVVGYFTHT DVLNYELSILISFVGALLGMLISYMIGRKAGRPFIDKYGKWVGLKEKRMMKVEKWMKK YGPYSLILGYFIPGVRHVTCYFSGIGKMDLKTYVAFAAIGAFLWCFVFITIGRVIGII HV*" /label="ybfM CDS" gene 229835..230323 /gene="ybfM" /locus_tag="BSU_02280" /old_locus_tag="BSU02280" /label="ybfM gene" CDS 230316..231107 /gene="psd" /locus_tag="BSU_02290" /old_locus_tag="BSU02290" /EC_number="4.1.1.65" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 14762009, 9422599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762009, 9422599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylserine decarboxylase; 32 kDa precursor processed into a 29 kDa protein" /protein_id="NP_388111.1" /db_xref="EnsemblGenomes-Gn:BSU02290" /db_xref="EnsemblGenomes-Tr:CAB12023" /db_xref="GOA:P39822" /db_xref="InterPro:IPR003817" /db_xref="InterPro:IPR033177" /db_xref="InterPro:IPR033178" /db_xref="SubtiList:BG11013" /db_xref="UniProtKB/Swiss-Prot:P39822" /translation="MFNTAVKILYRSLIELTNHRLSSYLIKGFCESKISKPVIPLFSK HFRLNWDDVDGTAADYGSLSELFIRQINLERRPVSKEAHAVVSPVDGVVQTVGIINPN QTFTVKGKDYSFAELTGCKSADHQYNGGYFVVLYLSPRHYHRFHSPISCRYQKLAELG NRSYPVNQLGLKYGKDVLSKNYRFVYELNSGSRNVLMIPVGAMNINSIVQTNTRTELE IGEELGYFSFGSTVILVFEKDAFQPSAHLAEGQEVQVGELIGYEE*" /label="psd CDS" gene 230316..231107 /gene="psd" /locus_tag="BSU_02290" /old_locus_tag="BSU02290" /label="psd gene" downshifts 231082 /Source="Nicolas_upshifts" /id="D86" /incds=0 /nref=101 /ntot=236 /MaxReadThrough="3.18138" /MaxDrop="4.25536" /score="-2.98360164" /energy="-8" /TU="U159" /idTUdmin="U160" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 231162..231440 /gene="ybfN" /locus_tag="BSU_02300" /old_locus_tag="BSU02300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388112.1" /db_xref="EnsemblGenomes-Gn:BSU02300" /db_xref="EnsemblGenomes-Tr:CAB12024" /db_xref="SubtiList:BG12742" /db_xref="UniProtKB/Swiss-Prot:O31454" /translation="MEKQIISWITDYQNTGDEAVLRQVREVCWPIVEAVLQEKVMDDE QANNLREKGIERFPFIISKYQADVQLPVETFLQNTYRFYFHQVMRESS*" /label="ybfN CDS" gene 231162..231440 /gene="ybfN" /locus_tag="BSU_02300" /old_locus_tag="BSU02300" /label="ybfN gene" promotor_-35 231483..231492 /Source="Nicolas_upshift_promotors" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 231501 /Source="Nicolas_upshifts" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 231505..231520 /Source="Nicolas_upshift_promotors" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 231546..232886 /gene="ybfO" /locus_tag="BSU_02310" /old_locus_tag="BSU02310" /EC_number="3.-.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported hydrolase" /protein_id="NP_388113.1" /db_xref="EnsemblGenomes-Gn:BSU02310" /db_xref="EnsemblGenomes-Tr:CAB12025" /db_xref="GOA:O31455" /db_xref="InterPro:IPR007815" /db_xref="SubtiList:BG12743" /db_xref="UniProtKB/Swiss-Prot:O31455" /translation="MKRMIVRMTLPLLIVCLAFSSFSASARAASEEKYWDHWIERHAQ PLDASNASNKDLRFLKKVLKGKRIVQLGETTHGAGEINATKVRMIKYLHEELGYDVLA FESGFPDTNASYLNMDQLTPKSTMKNSIYAVWHTEDVVELFDYMKEQKEKGDPLILTG FDIQSMKNSFNVAATQWVKAVDPEKAELLSQSENDFSTLVTDSNTFDEFSQKKEKLVK NYQKLIKFTKTHASELKENLPKEPKAYEMFMHSLQLRIDVMETYMLEEMKEKLEEYPE NIEDFSFFMRDRMMAEQFQWVADTLYPKKKIIVWGHNYHLRKQNTKMIKDWVQLNGPN MGDYLPERLKKQTYTIGIYAYSGASLDSSDNKTVKPVTSPPPSGSLEALLKAADRPAV FVDFLHTKNKKGTSWMYTPRTALYWGYMEEQMILKEQYDGVIWLEHITPSVIIK*" /label="ybfO CDS" gene 231546..232886 /gene="ybfO" /locus_tag="BSU_02310" /old_locus_tag="BSU02310" /label="ybfO gene" downshifts 232886 /Source="Nicolas_upshifts" /id="D87" /incds=0 /nref=12 /ntot=60 /MaxReadThrough="3.64301" /MaxDrop="6.34998" /score="14.4442651" /energy="-13.3" /TU="U161" /idTUdmin="U162" /TUdmin="-1122" /isTUend="FALSE" /label="downshifts" upshifts 232952 /Source="Nicolas_upshifts" /id="U162" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig="0.838161838161838" /xcortree=1579 /SigmaFactorBS="gtcccctgtggtaaacaggggatttttacatatcgcaaaaat aatcaaaacatataatccgtgATCCATTATTCTAAAACAGAaaggagattggagcgtg c" /listShort="ybfP, S89" /listLong="ybfQ" /label="upshifts" misc_feature 232955..232974 /Source="Nicolas_upshift_promotors" /id="U162" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig="0.838161838161838" /xcortree=1579 /SigmaFactorBS="gtcccctgtggtaaacaggggatttttacatatcgcaaaaat aatcaaaacatataatccgtgATCCATTATTCTAAAACAGAaaggagattggagcgtg c" /listShort="ybfP, S89" /listLong="ybfQ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 232994..233881 /gene="ybfP" /locus_tag="BSU_02320" /old_locus_tag="BSU02320" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388114.1" /db_xref="EnsemblGenomes-Gn:BSU02320" /db_xref="EnsemblGenomes-Tr:CAB12026" /db_xref="GOA:O31456" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12744" /db_xref="UniProtKB/Swiss-Prot:O31456" /translation="MYYEKAVQKTINWIESHLHEQISNEDIVNVSSFSKFHFHRIFQK EVGMSVASYIRLRRLANAAAALLYTDHRIIDIALYYQFESQEAFTRTFKKMYHMPPGA YRTFMKRFTSKKEESYMEKKMKGWVLSGSHPFQFEMGIDRENVHQGKASGYLKSTMVQ DIGEFATMMQQFKADRYLGKRLRLSSFIKTKGVQHFASLWMRVDSAADDVLQFDNMSN RPITGTTNWNHYAIVLDVPENSAVISFGVQLSGPGQVWMDHVVFEEVDESVPSTNLEM PGELLDEPVNLSFEEELQK*" /label="ybfP CDS" gene 232994..233881 /gene="ybfP" /locus_tag="BSU_02320" /old_locus_tag="BSU02320" /label="ybfP gene" S_feature 233882..234025 /Source="Nicolas_S_feature" /locus_tag="new_252315_252458" /HighExp="T0.30H, T-1.40H, T0.0H, T-1.10H, Salt, aero, ferm, T-0.40H, T-2.40H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.838, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S89" promotor_-35 233997..234004 /Source="Nicolas_upshift_promotors" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 234018..234037 /Source="Nicolas_upshift_promotors" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 234027 /Source="Nicolas_upshifts" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 234081..235049 /gene="ybfQ" /locus_tag="BSU_02330" /old_locus_tag="BSU02330" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme with rhodanese domain" /protein_id="NP_388115.1" /db_xref="EnsemblGenomes-Gn:BSU02330" /db_xref="EnsemblGenomes-Tr:CAB12027" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR020936" /db_xref="InterPro:IPR022111" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG12745" /db_xref="UniProtKB/Swiss-Prot:O31457" /translation="MEKQYRVLLYYKYVPIEDPEAFREQHLAFCKELGLLGRILVSSE GINGTVSGTVEQTEKYMETMKADPRFADMVFKIDEAEGHAFKKIFVRHKKELVTLRLE DDVDPNETTGQHLKPAEFYEKMQDPNTIVIDARNDYEYDLGHFRGAVRPDIEAFRELP EWIEEHKDMLEGKKILTYCTGGVRCEKFSGWLVKQGFEDVAQLDGGIVTYGKDPEVQG KLWDGQCYVFDERISVPVNRVEHVIVGKDYFTGEPCERYVNCANPSCNKKMICTPENE YKYMRSCSHECRTNPRNLYVKEHNMTEEEVNARLAAIETEDHAAAE*" /label="ybfQ CDS" gene 234081..235049 /gene="ybfQ" /locus_tag="BSU_02330" /old_locus_tag="BSU02330" /label="ybfQ gene" promotor_-10 complement(234903..234921) /Source="Nicolas_upshift_promotors" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(234920) /Source="Nicolas_upshifts" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(234937..234942) /Source="Nicolas_upshift_promotors" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 235046 /Source="Nicolas_upshifts" /id="D88" /incds=0 /nref=238 /ntot=271 /MaxReadThrough="2.06825" /MaxDrop="7.49655" /score="4.11635522" /energy="-7.8" /TU="U163" /idTUdmin="U161" /TUdmin=4 /isTUend="TRUE" /label="downshifts" downshifts complement(235085) /Source="Nicolas_upshifts" /id="D89" /incds=0 /nref=59 /ntot=147 /MaxReadThrough="0.54212" /MaxDrop="6.33244" /score="2.56774646" /energy="-7.5" /TU="NA" /idTUdmin="U165" /TUdmin=11 /isTUend="TRUE" /label="downshifts" CDS complement(235085..236329) /gene="gltP" /locus_tag="BSU_02340" /old_locus_tag="BSU02340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7751298, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7751298, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton/glutamate symport protein" /protein_id="NP_388116.1" /db_xref="EnsemblGenomes-Gn:BSU02340" /db_xref="EnsemblGenomes-Tr:CAB12028" /db_xref="GOA:P39817" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR033380" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG11015" /db_xref="UniProtKB/Swiss-Prot:P39817" /translation="MKKLIAFQILIALAVGAVIGHFFPDFGMALRPVGDGFIRLIKMI VVPIVFSTIVIGAAGSGSMKKMGSLGIKTIIWFEVITTLVLGLGLLLANVLKPGVGLD LSHLAKKDIHELSGYTDKVVDFKQMILDIIPTNIIDVMARNDLLAVIFFAILFGVAAA GIGKASEPVMKFFESTAQIMFKLTQIVMVTAPIGVLALMAASVGQYGIELLLPMFKLV GTVFLGLFLILFVLFPLVGLIFQIKYFEVLKMIWDLFLIAFSTTSTETILPQLMDRME KYGCPKRVVSFVVPSGLSLNCDGSSLYLSVSCIFLAQAFQVDMTLSQQLLMMLVLVMT SKGIAAVPSGSLVVLLATANAVGLPAEGVAIIAGVDRVMDMARTGVNVPGHAIACIVV SKWEKAFRQKEWVSANSQTESI*" /label="gltP CDS" gene complement(235085..236329) /gene="gltP" /locus_tag="BSU_02340" /old_locus_tag="BSU02340" /label="gltP gene" promotor_-10 complement(236363..236381) /Source="Nicolas_upshift_promotors" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(236372) /Source="Nicolas_upshifts" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(236392..236400) /Source="Nicolas_upshift_promotors" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(236400..236418) /Source="Nicolas_upshift_promotors" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(236416) /Source="Nicolas_upshifts" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(236434..236439) /Source="Nicolas_upshift_promotors" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(236474..238369) /gene="gamP" /locus_tag="BSU_02350" /old_locus_tag="BSU02350" /EC_number="2.7.1.193" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10627040, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) glucosamine-specific enzyme IICBA component" /protein_id="NP_388117.1" /db_xref="EnsemblGenomes-Gn:BSU02350" /db_xref="EnsemblGenomes-Tr:CAB12029" /db_xref="GOA:P39816" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011299" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11014" /db_xref="UniProtKB/Swiss-Prot:P39816" /translation="MFKKAFQILQQLGRALMTPVAVLPAAGLLLRFGDKDLLNIPIIK DAGGVVFDNLPLIFAVGVAIGLAGGEGVAGLAAVIGYLILTVTLDNMGKLLGLQPPYE GAEHLIDMGVFGGIIIGLLAAYLYKRFSSIELHPVLGFFSGKRFVPIITSVSSLVIGV IFSFVWPLIQNGINAASSLIADSTVGLFFYATIYRLLIPFGLHHIFYTPFYFMMGEYT DPSTGNTVTGDLTRFFAGDPTAGRFMMGDFPYMIFCLPAVALAIIHTARPEKKKMISG VMISAALTSMLTGITEPVEFSFLFVAPVLYLINSILAGVIFVVCDLFHVRHGYTFSGG GIDYVLNYGLSTNGWVVIPVGIVFAFIYYYLFRFAILKWNLKTPGRETDEDGQNEEKA PVAKDQLAFHVLQALGGQQNIANLDACITRLRVTVHQPSQVCKDELKRLGAVGVLEVN NNFQAIFGTKSDALKDDIKTIMAGGVPATAAALDTVTDKPLKPDSDETFIYPIKGETV SLGDVPDQVFSEKMMGEGFAIIPSEGKVVAPADGEIVSIFPTKHAIGFMSAGGTEILI HVGIDTVKLNGEGFEAHVTSGQAVKQGELLLTFDLNYIKQHAASAITPVIFTNTSEED LKHIQMK*" /label="gamP CDS" gene complement(236474..238369) /gene="gamP" /locus_tag="BSU_02350" /old_locus_tag="BSU02350" /label="gamP gene" downshifts complement(236490) /Source="Nicolas_upshifts" /id="D90" /incds=0 /nref=56 /ntot=192 /MaxReadThrough="1.9947" /MaxDrop="6.51864" /score="5.87664177" /energy="-12.1" /TU="NA" /idTUdmin="U168" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" misc_feature 238235..238254 /Source="Nicolas_upshift_promotors" /id="U167" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.701298701298701" /psig="0.975024975024975" /xcortree=2747 /SigmaFactorBS="cggcgaaaatcagcggaaggttatcgaatacaacgccgcccg cATCCTTTATAATAGGGATGTtcagtaaatccttgtctccgaaacggagcaaaagacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 238252 /Source="Nicolas_upshifts" /id="U167" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.701298701298701" /psig="0.975024975024975" /xcortree=2747 /SigmaFactorBS="cggcgaaaatcagcggaaggttatcgaatacaacgccgcccg cATCCTTTATAATAGGGATGTtcagtaaatccttgtctccgaaacggagcaaaagacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(238390..239139) /gene="gamA" /locus_tag="BSU_02360" /old_locus_tag="BSU02360" /EC_number="3.5.99.6" /function="16.11: Scavenge (Catabolism)" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:23667565, 27002132" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23667565, 27002132; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucosamine-6-phosphate deaminase" /protein_id="NP_388118.1" /db_xref="EnsemblGenomes-Gn:BSU02360" /db_xref="EnsemblGenomes-Tr:CAB12030" /db_xref="GOA:O31458" /db_xref="InterPro:IPR004547" /db_xref="InterPro:IPR006148" /db_xref="InterPro:IPR018321" /db_xref="SubtiList:BG12746" /db_xref="UniProtKB/Swiss-Prot:O31458" /translation="MKILIAEHYEELCKLSAAIIKEQIQAKKDAVLGLATGSTPVGLY KQLISDYQAGEIDFSKVTTFNLDEYAGLSPSHPQSYNHFMHEHLFQHINMQPDHIHIP QGDNPQLEAACKVYEDLIRQAGGIDVQILGIGANGHIGFNEPGSDFEDRTRVVKLSES TIQANARFFGGDPVLVPRLAISMGIKTIMEFSKHIVLLASGEEKADAIQKMAEGPVTT DVPASILQKHNHVTVIADYKAAQKLKSASFS*" /label="gamA CDS" gene complement(238390..239139) /gene="gamA" /locus_tag="BSU_02360" /old_locus_tag="BSU02360" /label="gamA gene" S_feature 239112..239293 /Source="Nicolas_S_feature" /locus_tag="new_257545_257726" /HighExp="H2O2, T1.30H, G135, dia15, G150, G180, LBGstat, T2.0H, T0.30H, M9-stat" /AntisenseName="nagBB" /AntisenseCor="0.458837556034909" /AntisenseRegPval="-14.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S90" S_feature complement(239140..239210) /Source="Nicolas_S_feature" /locus_tag="new_257573_257643_c" /HighExp="S1, Diami, MG 5, MG t5, dia5, MG 15, MG 10, LPhT, Paraq, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S91" promotor_-10 complement(239199..239218) /Source="Nicolas_upshift_promotors" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(239214) /Source="Nicolas_upshifts" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(239234..239241) /Source="Nicolas_upshift_promotors" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 239280..239287 /Source="Nicolas_upshift_promotors" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 239295 /Source="Nicolas_upshifts" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 239300..239319 /Source="Nicolas_upshift_promotors" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 239358..240065 /gene="gamR" /locus_tag="BSU_02370" /old_locus_tag="BSU02370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23667565, 24673833" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23667565, 24673833; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator-GlcN6P (GntR family)" /protein_id="NP_388119.1" /db_xref="EnsemblGenomes-Gn:BSU02370" /db_xref="EnsemblGenomes-Tr:CAB12031" /db_xref="GOA:O31459" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12747" /db_xref="UniProtKB/Swiss-Prot:O31459" /translation="MTALYSVIKFKIIELIKSGKYQANDQLPTESEFCEQYDVSRTTV RLALQQLELEGYIKRIQGKGTFVSAAKIQTPIPHKITSFAEQMRGLRSESKVLELVVI PADHSIAELLKMKENEPVNKLVRVRYAEGEPLQYHTSYIPWKAAPGLAQEECTGSLFE LLRTKYNIEISRGTESIEPILTDETISGHLLTNVGAPAFLSESLTYDKNEEVVEYAQI ITRGDRTKFTVEQSYHS*" /label="gamR CDS" gene 239358..240065 /gene="gamR" /locus_tag="BSU_02370" /old_locus_tag="BSU02370" /label="gamR gene" promotor_-35 240031..240032 /Source="Nicolas_upshift_promotors" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 240048..240062 /Source="Nicolas_upshift_promotors" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 240058 /Source="Nicolas_upshifts" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="upshifts" CDS 240099..240374 /gene="ybgB" /locus_tag="BSU_02380" /old_locus_tag="BSU02380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12897008, 23667565" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (B. subtilis-specific)" /protein_id="NP_388120.1" /db_xref="EnsemblGenomes-Gn:BSU02380" /db_xref="EnsemblGenomes-Tr:CAB12032" /db_xref="GOA:O31460" /db_xref="InterPro:IPR012867" /db_xref="SubtiList:BG12748" /db_xref="UniProtKB/Swiss-Prot:O31460" /translation="MFLFTNGKVLWGAVIAAFILSIVFYPFLPTQMPIHYDVANSPDL TVNKLAGTVMLPVLMVVFAWARKINWQFVFAVYILLICHIVVLCLAL*" /label="ybgB CDS" gene 240099..240374 /gene="ybgB" /locus_tag="BSU_02380" /old_locus_tag="BSU02380" /label="ybgB gene" promotor_-10 complement(240157..240175) /Source="Nicolas_upshift_promotors" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(240163) /Source="Nicolas_upshifts" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(240190..240196) /Source="Nicolas_upshift_promotors" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 240366 /Source="Nicolas_upshifts" /id="D91" /incds=0 /nref=20 /ntot=130 /MaxReadThrough="2.42422" /MaxDrop="3.75723" /score="4.58454735" /energy="-9.4" /TU="NA" /idTUdmin="U169" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 240417..240421 /Source="Nicolas_upshift_promotors" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 240437..240456 /Source="Nicolas_upshift_promotors" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 240443 /Source="Nicolas_upshifts" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="upshifts" S_feature 240454..240582 /Source="Nicolas_S_feature" /locus_tag="new_258887_259015" /HighExp="T2.30H, S5, T2.0H, T1.30H, M9-stat, T3.0H, T3.30H, S4, T1.0H, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S92" CDS 240583..241653 /gene="ilvE" /locus_tag="BSU_02390" /old_locus_tag="BSU02390" /EC_number="2.6.1.42" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 15060025, 15102328, 20332210, 23429746" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 15060025, 15102328, 20332210, 23429746; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoleucine-valine aminotransferase / aromatic amino acid aminotransferase" /protein_id="NP_388121.1" /db_xref="EnsemblGenomes-Gn:BSU02390" /db_xref="EnsemblGenomes-Tr:CAB12033" /db_xref="GOA:O31461" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005786" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR033939" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG12749" /db_xref="UniProtKB/Swiss-Prot:O31461" /translation="MNKLIEREKTVYYKEKPDPSSLGFGQYFTDYMFVMDYEEGIGWH HPRIAPYAPLTLDPSSSVFHYGQAVFEGLKAYRTDDGRVLLFRPDQNIKRLNRSCERM SMPPLDEELVLEALTQLVELEKDWVPKEKGTSLYIRPFVIATEPSLGVKASRSYTFMI VLSPVGSYYGDDQLKPVRIYVEDEYVRAVNGGVGFAKTAGNYAASLQAQRKANELGYD QVLWLDAIEKKYVEEVGSMNIFFVINGEAVTPALSGSILSGVTRASAIELIRSWGIPV REERISIDEVYAASARGELTEVFGTGTAAVVTPVGELNIHGKTVIVGDGQIGDLSKKL YETITDIQLGKVKGPFNWTVEV*" /label="ilvE CDS" gene 240583..241653 /gene="ilvE" /locus_tag="BSU_02390" /old_locus_tag="BSU02390" /label="ilvE gene" downshifts 241642 /Source="Nicolas_upshifts" /id="D92" /incds=0 /nref=124 /ntot=245 /MaxReadThrough="1.34575" /MaxDrop="6.88046" /score="13.1364544" /energy="-9.4" /TU="NA" /idTUdmin="U172" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(241690..243102) /gene="ybgF" /locus_tag="BSU_02400" /old_locus_tag="BSU02400" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7704263, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid permease" /protein_id="NP_388122.1" /db_xref="EnsemblGenomes-Gn:BSU02400" /db_xref="EnsemblGenomes-Tr:CAB12034" /db_xref="GOA:O31462" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12750" /db_xref="UniProtKB/Swiss-Prot:O31462" /translation="MNSAHNKNETTFQRSMKSRHLFMLSLGGVIGTGLFLSSGYTIQQ AGPAGTILAYLVGAGIVYLVMLCLGELSVAMPVTGAFHTYAAKYIGPGTGFTVAWLYW LTWTVALGSEFTAAGLLMQRWFPHTSVWMWSAVFALFIFLLNAFSVKFFAESEFWFSS IKVLAIVLFILLGGSAMFGIIPIKGGEAAPMLSNFTAEGGLFPNGFVPILMTMLSVNF AFSGTELIGIAAGESVDPDKTIPKAIKTTVWRLSLFFVGTIFVLSGLIPIQDAGVIKS PFVAVFDRVGVPYAADIMNFVILTAILSAANSGLYASSRMLWSLSKEKTLHPTFAKLT SKGTPFNALVFSMIGGILSLLSSVFAPDTVYVVLVSISGFAVVVVWMGIAASQFMFRK RYIEAGNKVTDLKYRTPLYPFVPIAAFLLCLASVVGIAFDPNQRIALYCGVPFMAICY AIYYVKNRKSQPAADMTHSK*" /label="ybgF CDS" gene complement(241690..243102) /gene="ybgF" /locus_tag="BSU_02400" /old_locus_tag="BSU02400" /label="ybgF gene" downshifts complement(241707) /Source="Nicolas_upshifts" /id="D93" /incds=0 /nref=43 /ntot=166 /MaxReadThrough="0.37503" /MaxDrop="5.92001" /score="6.94246417" /energy="-9.4" /TU="NA" /idTUdmin="U173" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" S_feature complement(243103..243214) /Source="Nicolas_S_feature" /locus_tag="new_261536_261647_c" /HighExp="BMM, S1, MG 45, MG 60, UNK1, MG t5, MG 10, MG 90, MG-0.2, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S93" promotor_-10 complement(243187..243206) /Source="Nicolas_upshift_promotors" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(243214) /Source="Nicolas_upshifts" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(243221..243228) /Source="Nicolas_upshift_promotors" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(243223..244170) /gene="ybgG" /locus_tag="BSU_02410" /old_locus_tag="BSU02410" /EC_number="2.1.1.10" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11267663, 15995196, 17264075; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homocysteine methylase using (R,S)AdoMet" /protein_id="NP_388123.1" /db_xref="EnsemblGenomes-Gn:BSU02410" /db_xref="EnsemblGenomes-Tr:CAB12035" /db_xref="GOA:O31463" /db_xref="InterPro:IPR003726" /db_xref="InterPro:IPR017226" /db_xref="InterPro:IPR036589" /db_xref="SubtiList:BG12751" /db_xref="UniProtKB/Swiss-Prot:O31463" /translation="MNPIQHILDTYPLIVLDGAMATELERKGCNLNDSLWSAKILMEE PELIKQVHTDYFAAGADCAITASYQSTFEGFAARGLSEAEARRLIELSVSIAAEARDE FWSLEENRLNRPKPIIAASIGPYGAYLADGSEYRGNYAISEDELIEFHRPRMKALIEA GADVLACETIPCLTEAKAIVRLLKEFPETYAWISFSAKDGLHISDGTPAADCASWLDE HRQIAALGINCTPLQHIPSLIEELKKNTSKPIIVYPNSGEQYDPETKTWNGAACAESY GASARTWHEKGARLIGGCCRTKPENIQEIAAWARSLKTT*" /label="ybgG CDS" gene complement(243223..244170) /gene="ybgG" /locus_tag="BSU_02410" /old_locus_tag="BSU02410" /label="ybgG gene" promotor_-10 complement(244208..244227) /Source="Nicolas_upshift_promotors" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="promotor_-10" upshifts complement(244225) /Source="Nicolas_upshifts" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="upshifts" promotor_-35 complement(244242..244249) /Source="Nicolas_upshift_promotors" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="promotor_-35" CDS complement(244299..245735) /gene="glnT" /locus_tag="BSU_02420" /old_locus_tag="BSU02420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 15995196, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine transporter" /protein_id="NP_388124.2" /db_xref="EnsemblGenomes-Gn:BSU02420" /db_xref="EnsemblGenomes-Tr:CAB12036" /db_xref="GOA:O31464" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG12752" /db_xref="UniProtKB/Swiss-Prot:O31464" /translation="MQQILEHIVGIANDLLWSKLLIVLLLSFGIYFTFRLKFLQVRML KEMVRVLREGAASRSKNSISPFQAFCISMAARVGTGNITGIAIAIALGGPGAIFWMWI IAIIGSASSFVESTLAQIYKVKDVNGFRGGPAYYMEKGLNKRWMGALFAVLITLSFGI VFNSVQSNTVSLAFENAFGTNRLTLGLILIAVFGTIIFGGVKRIAKLAESIVVVLAVL YIGVAFFVIFSNITQLPGVLALIVKNAFGFDQAAGGALGAALMQGVRRGIFSNEAGMG SAPNAAATATTSHPVKQGLIQAFGVLTDTLVICTSTAFIILFSDAYHTPGLSGIALTQ ASLSSHVGSWASGFLAILILLFGFCALIGNYYYGETNIGFLNKSKKLIFVYRIGVLAM IVFGCVAKVQLVWDLADLFMGLMVIVNLIAIFLLSKVVFTALKDYTRQKKAGKDPVFY KDVLKNHNGIECWPVSDTKTDTHNKQIS*" /label="glnT CDS" gene complement(244299..245735) /gene="glnT" /locus_tag="BSU_02420" /old_locus_tag="BSU02420" /label="glnT gene" downshifts complement(244314) /Source="Nicolas_upshifts" /id="D94" /incds=0 /nref=3 /ntot=3 /MaxReadThrough="0.598370000000001" /MaxDrop="4.3935" /score="-7.90227391" /energy="-11.4" /TU="NA" /idTUdmin="U174" /TUdmin="-1078" /isTUend="FALSE" /label="downshifts" CDS complement(245758..246741) /gene="glsA" /locus_tag="BSU_02430" /old_locus_tag="BSU02430" /EC_number="3.5.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15995196, 18459799, 20050917" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995196, 18459799, 20050917; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutaminase" /protein_id="NP_388125.1" /db_xref="EnsemblGenomes-Gn:BSU02430" /db_xref="EnsemblGenomes-Tr:CAB12037" /db_xref="GOA:O31465" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR015868" /db_xref="PDB:1MKI" /db_xref="PDB:2OSU" /db_xref="PDB:3AGF" /db_xref="PDB:3BRM" /db_xref="SubtiList:BG12753" /db_xref="UniProtKB/Swiss-Prot:O31465" /translation="MKELIKEHQKDINPALQLHDWVEYYRPFAANGQSANYIPALGKV NDSQLGICVLEPDGTMIHAGDWNVSFTMQSISKVISFIAACMSRGIPYVLDRVDVEPT GDAFNSIIRLEINKPGKPFNPMINAGALTIASILPGESAYEKLEFLYSVMETLIGKRP RIHEEVFRSEWETAHRNRALAYYLKETNFLEAEVEETLEVYLKQCAMESTTEDIALIG LILAHDGYHPIRHEQVIPKDVAKLAKALMLTCGMYNASGKYAAFVGVPAKSGVSGGIM ALVPPSARREQPFQSGCGIGIYGPAIDEYGNSLTGGMLLKHMAQEWELSIF*" /label="glsA CDS" gene complement(245758..246741) /gene="glsA" /locus_tag="BSU_02430" /old_locus_tag="BSU02430" /label="glsA gene" promotor_-10 complement(246835..246852) /Source="Nicolas_upshift_promotors" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 246840..246859 /Source="Nicolas_upshift_promotors" /id="U176" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=1812 /SigmaFactorBS="tcaaaacgaaggctaagggggcgttaaacgctttcataatag cggaaggtataaTTACTGTATAATGGAGACTAcagaatcatacaaaatacgacaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(246842) /Source="Nicolas_upshifts" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts 246846 /Source="Nicolas_upshifts" /id="U176" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=1812 /SigmaFactorBS="tcaaaacgaaggctaagggggcgttaaacgctttcataatag cggaaggtataaTTACTGTATAATGGAGACTAcagaatcatacaaaatacgacaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(246868..246875) /Source="Nicolas_upshift_promotors" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 247043..248275 /gene="glnJ" /locus_tag="BSU_02440" /old_locus_tag="BSU02440" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15995196, 17001076, 21435182, 23461034, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15995196, 17001076, 21435182, 23461034, 25691471; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [GlnL] forglutamine degradation" /protein_id="NP_388126.2" /db_xref="EnsemblGenomes-Gn:BSU02440" /db_xref="EnsemblGenomes-Tr:CAB12038" /db_xref="GOA:P40758" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10871" /db_xref="UniProtKB/Swiss-Prot:P40758" /translation="MLITVPLAGELKFYPLNEEFRVSFGAPVFFFFLSLLRHVPAVLP GFLTGAAVFIFRVFLELWGGGHNGLTPILYDQASGFFFYMTYACLFSILKANRFRERP IMLGFIGFMIEVVSDCVELTVQFLIFHTVVTPEKITDIAVIAISHTFIVMSFYSVLKL YETQSREKQTRQQHEHMLMIVSNLYEETVHLKKTLKTTEKVTNDSYQLYREMKGKDVQ LSGRILRLAGEIHEVKKDNQRIFAGLSKLISNESLRDYMRASDLLQLVIRMNEKYAEA LGKQIDFYCSIEGEHDEYHVFIVLSIINNLTANAVEAMDEEGMVSLRLRKPNESMVEF QVEDNGPGISEKIGDIVFDPGFTSKYDEFGTPSTGIGLSYVKEIVTELEGDITFDNQQ RGVVFAIRLPVRHLIQKG*" /label="glnJ CDS" gene 247043..248275 /gene="glnJ" /locus_tag="BSU_02440" /old_locus_tag="BSU02440" /label="glnJ gene" CDS 248286..249230 /gene="glnL" /locus_tag="BSU_02450" /old_locus_tag="BSU02450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15995196" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15995196; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [GlnJ] for glutamine utilisation" /protein_id="NP_388127.1" /db_xref="EnsemblGenomes-Gn:BSU02450" /db_xref="EnsemblGenomes-Tr:CAB12039" /db_xref="GOA:P40759" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR013972" /db_xref="SubtiList:BG10872" /db_xref="UniProtKB/Swiss-Prot:P40759" /translation="MRFFIADDDRAVRSILRQIIEDEDLGEAAGEADDGSQVEGHMLQ FKQIDILLIDLLMPGRDGIETIRQIQNTYSGKIVMISQVEAKEMVGEAYSLGIEYFIH KPINRIEIVTVLQKVKERIELEHSIGAIQHSLSRLVNRTERKARPQQKSDSGLKEAGT FLLSELGMMGEGGAHDLMAVLQYLAEHEQSEPHEKQSPSLKQIFTQVAVRKLGTGASQ TEVNREMKASEQRIRRAIIHSLHHFASLGTTDFSNPKFETYASKFFDFPVVSQKMKEL QSKDAKPLAPARINMKKFIHVFFLEAKLLHETMKQRRI*" /label="glnL CDS" gene 248286..249230 /gene="glnL" /locus_tag="BSU_02450" /old_locus_tag="BSU02450" /label="glnL gene" downshifts 249207 /Source="Nicolas_upshifts" /id="D95" /incds=0 /nref=45 /ntot=191 /MaxReadThrough="1.43757" /MaxDrop="3.64091" /score="2.73020459" /energy="-6.2" /TU="NA" /idTUdmin="U177" /TUdmin="-484" /isTUend="FALSE" /label="downshifts" promotor_-35 249327..249334 /Source="Nicolas_upshift_promotors" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 249339..249456 /Source="Nicolas_S_feature" /locus_tag="new_267772_267889" /HighExp="Sw, BC, M40t90, Etha, MG-0.2, HiTm, HiOs, G135, UNK1, MG-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S94" upshifts 249339 /Source="Nicolas_upshifts" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 249348..249367 /Source="Nicolas_upshift_promotors" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 249457..250383 /gene="kdgD" /locus_tag="BSU_02460" /old_locus_tag="BSU02460" /EC_number="4.2.1.41" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12044674; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="5-dehydro-4-deoxyglucarate dehydratase" /protein_id="NP_388128.2" /db_xref="EnsemblGenomes-Gn:BSU02460" /db_xref="EnsemblGenomes-Tr:CAB12040" /db_xref="GOA:P42235" /db_xref="InterPro:IPR002220" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017655" /db_xref="SubtiList:BG11158" /db_xref="UniProtKB/Swiss-Prot:P42235" /translation="MSRIRKAPAGILGFPVAPFNTQGKLEEEALFQNIEFLLNEGLEA IFIACGSGEFQSLSQKEYEQMVEVAVSAAGGKVPVYTGVGGNLSTALDWAQLSEKKGA DGYLILPPYLVHGEQEGLYQYAKTIIESTDLNAILYQRDNAVLSVEQIKRLTECEQLV GVKDGVGNMDLNINLVYTIGDRLGWLNGMPMAEVTMPAYLPIGFHSYSSAISNYIPHI SRMFYDALKNGNDELVKELYRHVILPINDIRKQRKGYAVSLIKAGMEIMGLNVRNTAR PPVGPVEKDHYQQLEAILKQAADRFPKKAATV*" /label="kdgD CDS" gene 249457..250383 /gene="kdgD" /locus_tag="BSU_02460" /old_locus_tag="BSU02460" /label="kdgD gene" CDS 250413..251879 /gene="gucD" /locus_tag="BSU_02470" /old_locus_tag="BSU02470" /EC_number="1.2.1.26" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12044674, 17202142; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,5-dioxovalerate dehydrogenase (alpha-ketoglutaric semialdehyde dehydrogenase)" /protein_id="NP_388129.1" /db_xref="EnsemblGenomes-Gn:BSU02470" /db_xref="EnsemblGenomes-Tr:CAB12041" /db_xref="GOA:P42236" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11159" /db_xref="UniProtKB/Swiss-Prot:P42236" /translation="MSVITEQNTYLNFINGEWVKSQSGDMVKVENPADVNDIVGYVQN STAEDVERAVTAANEAKTAWRKLTGAERGQYLYKTADIMEQRLEEIAACATREMGKTL PEAKGETARGIAILRYYAGEGMRKTGDVIPSTDKDALMFTTRVPLGVVGVISPWNFPV AIPIWKMAPALVYGNTVVIKPATETAVTCAKIIACFEEAGLPAGVINLVTGPGSVVGQ GLAEHDGVNAVTFTGSNQVGKIIGQAALARGAKYQLEMGGKNPVIVADDADLEAAAEA VITGAFRSTGQKCTATSRVIVQSGIYERFKEKLLQRTKDITIGDSLKEDVWMGPIASK NQLDNCLSYIEKGKQEGASLLIGGEKLENGKYQNGYYVQPAIFDNVTSEMTIAQEEIF GPVIALIKVDSIEEALNIANDVKFGLSASIFTENIGRMLSFIDEIDAGLVRINAESAG VELQAPFGGMKQSSSHSREQGEAAKDFFTAIKTVFVKP*" /label="gucD CDS" gene 250413..251879 /gene="gucD" /locus_tag="BSU_02470" /old_locus_tag="BSU02470" /label="gucD gene" CDS 251963..253330 /gene="gudP" /locus_tag="BSU_02480" /old_locus_tag="BSU02480" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12044674, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12044674, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glucarate transporter" /protein_id="NP_388130.2" /db_xref="EnsemblGenomes-Gn:BSU02480" /db_xref="EnsemblGenomes-Tr:CAB12042" /db_xref="GOA:P42237" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR004744" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11160" /db_xref="UniProtKB/Swiss-Prot:P42237" /translation="MKKDFASVTPAGKKTSVRWFIVFMLFLVTSINYADRATLSITGD SVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFTLLQ GAIGFFSAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQY FAIVIFSPLMGWLTHSFGWHSVFVVMGIAGILLAVIWLKTVYEPKKHPKVNEAELAYI EQGGGLISMDDSKSKQETESKWPYIKQLLTNRMLIGVYIAQYCITTLTYFFLTWFPVY LVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDILLKKGRSLTFARKVPIIAGMLL SCSMIVCNYTDSAWLVVVIMSLAFFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGN IASITTPIIIGYIVNATGSFNGALVFVGANAIAAILSYLLLVGPIKRVVLKKQEQDPD QSLPV*" /label="gudP CDS" gene 251963..253330 /gene="gudP" /locus_tag="BSU_02480" /old_locus_tag="BSU02480" /label="gudP gene" CDS 253367..254734 /gene="gudD" /locus_tag="BSU_02490" /old_locus_tag="BSU02490" /EC_number="4.2.1.40" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9772161, 12044674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucarate dehydratase" /protein_id="NP_388131.2" /db_xref="EnsemblGenomes-Gn:BSU02490" /db_xref="EnsemblGenomes-Tr:CAB12043" /db_xref="GOA:P42238" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR017653" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR034598" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG11161" /db_xref="UniProtKB/Swiss-Prot:P42238" /translation="MSSPIQEQVQKEKRSNIPSISEMKVIPVAGHDSMLLNLSGAHSP FFTRNIVILTDSSGNQGVGEVPGGEHIRRTLELSEPLVVGKSIGAYQAILQTVRKQFG DQDRGGRGNQTFDLRTTVHAVTALEAALLDLLGKFLQEPVAALLGEGKQRDEVKMLGY LFYIGDRNRTTLPYQSDEQSDCAWFRLRHEEALTPEAIVRLAESAQERYGFQDFKLKG GVLRGEEEIEAVTALSKRFPEARITLDPNGAWSLEEAIALCKGKQDVLAYAEDPCGDE NGYSAREVMAEFRRATGLPTATNMIATDWREMGHAIQLHAVDIPLADPHFWTMQGSVR VAQMCHDWGLTWGSHSNNHFDISLAMFTHVAAAAPGRITAIDTHWIWQDGQRLTKQPF EISSGCVKVPDKPGLGVDIDMEQVEKAHEIYRKMNLGARNDAIPMQFLISNWEFDRKR PCLVR*" /label="gudD CDS" gene 253367..254734 /gene="gudD" /locus_tag="BSU_02490" /old_locus_tag="BSU02490" /label="gudD gene" promotor_-35 254748..254755 /Source="Nicolas_upshift_promotors" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="promotor_-35" promotor_-10 254770..254787 /Source="Nicolas_upshift_promotors" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="promotor_-10" upshifts 254773 /Source="Nicolas_upshifts" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="upshifts" CDS 254804..255505 /gene="garR" /locus_tag="BSU_02500" /old_locus_tag="BSU02500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12044674" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12044674; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family)" /protein_id="NP_388132.2" /db_xref="EnsemblGenomes-Gn:BSU02500" /db_xref="EnsemblGenomes-Tr:CAB12044" /db_xref="GOA:P42239" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11162" /db_xref="UniProtKB/Swiss-Prot:P42239" /translation="MYEGLEDLKVDTVNRKTLAKQVIERIVHLLSSGQLRAGDKLPTE MELMDILHVSRPVLREALSSLETLGVITRKTRGGTYFNDKIGMQPFSVMLALATDNLP AIIEARMALELGLVTIAAEKINEEELQRLQKTIDDIANSTDNHYGEADKEFHRIIALS ANNPVVEGMIQSLLITHAKIDSQIPYRERDVTVEYHKKIYDALAKRDPYKAHYHMYEH LKFVRDKILKGMDEK*" /label="garR CDS" gene 254804..255505 /gene="garR" /locus_tag="BSU_02500" /old_locus_tag="BSU02500" /label="garR gene" downshifts 255455 /Source="Nicolas_upshifts" /id="D96" /incds=0 /nref=1 /ntot=35 /MaxReadThrough="3.59234" /MaxDrop="2.3923" /score="4.10541728" /energy="-9.5" /TU="U178" /idTUdmin="U178" /TUdmin="-1694" /isTUend="FALSE" /label="downshifts" downshifts 255499 /Source="Nicolas_upshifts" /id="D97" /incds=0 /nref=1 /ntot=82 /MaxReadThrough="3.21794" /MaxDrop="2.49226" /score="4.10541728" /energy="-9.5" /TU="U178" /idTUdmin="U178" /TUdmin="-1650" /isTUend="FALSE" /label="downshifts" CDS 255596..257128 /gene="garD" /locus_tag="BSU_02510" /old_locus_tag="BSU02510" /EC_number="4.2.1.42" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9772162; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-galactarate dehydratase" /protein_id="NP_388133.2" /db_xref="EnsemblGenomes-Gn:BSU02510" /db_xref="EnsemblGenomes-Tr:CAB12045" /db_xref="GOA:P42240" /db_xref="InterPro:IPR007392" /db_xref="InterPro:IPR013974" /db_xref="InterPro:IPR017654" /db_xref="SubtiList:BG11163" /db_xref="UniProtKB/Swiss-Prot:P42240" /translation="MAMNLRKNQAPLYIKVHEIDNTAIIVNDGGLPKGTVFSCGLVLE EDVPQGHKVALTDLNQGDEIVRYGEVIGFADETIKRGSWIREALVRMPAPPALDDLPL ANRVPQPRPPLEGYTFEGYRNADGSAGTKNILGITTSVQCVVGVLDYAVKRIKEELLP KYPNVDDVVPLHHQYGCGVAINAPDAVIPIRTIQNLAKHPNFGGEVMVIGLGCEKLLP ERIASENDDDILSLQDHRGFAAMIQSILEMAEERLIRLNSRTRVSCPVSDLVIGLQCG GSDAFSGVTANPAVGYAADLLVRAGATVLFSEVTEVRDAIHLLTPRAVSEEVGQSLIK EMKWYDSYLRRGDADRSANPSPGNKKGGLSNVVEKALGSVAKSGTSPISGVLGPGERA KQKGLLFAATPASDFVCGTLQLAAGMNLQVFTTGRGTPYGLAAAPVLKVSTRHSLSEH WADLIDINAGRIATGEASIEDVGWEIFRTILDVASGRKQTWADRWGLHNDLCLFNPAP VT*" /label="garD CDS" gene 255596..257128 /gene="garD" /locus_tag="BSU_02510" /old_locus_tag="BSU02510" /label="garD gene" promotor_-35 257140..257143 /Source="Nicolas_upshift_promotors" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 257158..257177 /Source="Nicolas_upshift_promotors" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 257170..257404 /Source="Nicolas_S_feature" /locus_tag="new_275603_275837" /HighExp="LoTm, Sw, BC, BI, B60, B36, T3.30H, T5.0H, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.50265400000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S95" upshifts 257170 /Source="Nicolas_upshifts" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="upshifts" CDS 257405..258325 /gene="ycbJ" /locus_tag="BSU_02520" /old_locus_tag="BSU02520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12044674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase" /protein_id="NP_388134.1" /db_xref="EnsemblGenomes-Gn:BSU02520" /db_xref="EnsemblGenomes-Tr:CAB12046" /db_xref="GOA:P42242" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG11165" /db_xref="UniProtKB/Swiss-Prot:P42242" /translation="MTNLNEKQLITEIVGLARSQGLTVHSENAQLNETGMDFQVVFAK DDTGMPWVLRKPRRSDVVERASAEGITLAFLRANLTADVPDWRIHTPELIAYPMLKGT PAAGIDLEQKQYVWNMDHQPPSDDFVRTLADILAELHGTDQISAGQSGIEVIRPEDFR QMTADSMVDVKNKLGVSTTLWERWQKWVDDDAYWPGFSSLIHGDLHPPHILIDQNGRV TGLLDWTEAKVADPAKDFVLYQTIFGEKETARLLEYYDQAGGRIWAKMQEHISEMQAA YPVEIAKLALQTQQEEHINMALEALGVTSD*" /label="ycbJ CDS" gene 257405..258325 /gene="ycbJ" /locus_tag="BSU_02520" /old_locus_tag="BSU02520" /label="ycbJ gene" promotor_-35 258327..258334 /Source="Nicolas_upshift_promotors" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 258349..258368 /Source="Nicolas_upshift_promotors" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 258359 /Source="Nicolas_upshifts" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 258382..258629 /gene="tboW" /locus_tag="BSU_misc_RNA_6" /product="T-box riboswitch specific of tryptophan tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 10706627, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 10706627, 12165569, 12547201; Product type n: RNA" /label="tboW RNA" gene 258382..258629 /gene="tboW" /locus_tag="BSU_misc_RNA_6" /label="tboW gene" downshifts 258598 /Source="Nicolas_upshifts" /id="D98" /incds=0 /nref=225 /ntot=264 /MaxReadThrough="2.36361" /MaxDrop="6.52913" /score="36.5571172" /energy="-16.6" /TU="NA" /idTUdmin="U179" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS 258727..258888 /gene="rtpA" /locus_tag="BSU_02530" /old_locus_tag="BSU02530" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10706627, 11557884, 12855807, 15099736, 15213402, 15743934, 16306262" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10706627, 11557884, 12855807, 15099736, 15213402, 15743934, 16306262; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-TRAP regulator" /protein_id="NP_388135.1" /db_xref="EnsemblGenomes-Gn:BSU02530" /db_xref="EnsemblGenomes-Tr:CAB12047" /db_xref="GOA:O31466" /db_xref="InterPro:IPR031538" /db_xref="InterPro:IPR036410" /db_xref="PDB:2BX9" /db_xref="PDB:2KO8" /db_xref="PDB:2ZP8" /db_xref="PDB:2ZP9" /db_xref="SubtiList:BG12776" /db_xref="UniProtKB/Swiss-Prot:O31466" /translation="MVIATDDLEVACPKCERAGEIEGTPCPACSGKGVILTAQGYTLL DFIQKHLNK*" /label="rtpA CDS" gene 258727..258888 /gene="rtpA" /locus_tag="BSU_02530" /old_locus_tag="BSU02530" /label="rtpA gene" promotor_no_box 258805..258905 /Source="Nicolas_upshift_promotors" /id="U181" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.010989010989011" /xcortree=1479 /SigmaFactorBS="ccggcctgcagcggaaaaggtgttattctgactgctcaagga tatacgcttctcgattttatccaaaagcatttgaataagtaaaggagaaaagctgagc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 258865 /Source="Nicolas_upshifts" /id="U181" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.010989010989011" /xcortree=1479 /SigmaFactorBS="ccggcctgcagcggaaaaggtgttattctgactgctcaagga tatacgcttctcgattttatccaaaagcatttgaataagtaaaggagaaaagctgagc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 258909..259847 /gene="ycbK" /locus_tag="BSU_02540" /old_locus_tag="BSU02540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10706627, 15063849, 15849754, 16850406, 16879415, 17114263; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative tryptophan or indole exporter" /protein_id="NP_388136.1" /db_xref="EnsemblGenomes-Gn:BSU02540" /db_xref="EnsemblGenomes-Tr:CAB12048" /db_xref="GOA:P42243" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG11166" /db_xref="UniProtKB/Swiss-Prot:P42243" /translation="MRAEEQSKIREAAAGTIFLLIGTVCFASKSIWIKWAYQMGAEPD AVLLYRQLLAVPLFWLIFLIYRPPMPDGKKKGDLWKACGAGVFCFFLSPLLDFIGLNH VSAMVERILLMSYPLFVFGFTACRDRKMSSIQDLFAVLAVMFGLFLALGGWNAELFQA NMIGAVFILLSSAVYAGYLVLSGHLVHQIGGIRLNAYGMTAAGAAMMLYTGIKSAAGM NTPMAAYPLSMYGLFAVIAVVTTVIPFVLMLEGIKRIGAQRAAAISMAGPILTIFYGA LFLGERLGLIQVIGCGGVFFVITGMEYRKLKTGKKE*" /label="ycbK CDS" gene 258909..259847 /gene="ycbK" /locus_tag="BSU_02540" /old_locus_tag="BSU02540" /label="ycbK gene" downshifts 258953 /Source="Nicolas_upshifts" /id="D99" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="3.05417" /MaxDrop="3.72787" /score="0.773303272" /energy="-9" /TU="NA" /idTUdmin="U181" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 259870..259889 /Source="Nicolas_upshift_promotors" /id="U182" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.699300699300699" /psig="0.998001998001998" /xcortree=2265 /SigmaFactorBS="tacaggaagctgaaaacaggaaaaaaagaataatttttataa aacacacacgtttTTCAATTACAATAAGTGTAAttacgtgtgtgttttttgattttgt a" /listShort="S96, ycbL, ycbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 259875..259943 /Source="Nicolas_S_feature" /locus_tag="new_278308_278376" /HighExp="C90, dia5, Lbtran, Lbexp, LBGexp, SMM, dia0, dia15, BMM, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S96" upshifts 259875 /Source="Nicolas_upshifts" /id="U182" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.699300699300699" /psig="0.998001998001998" /xcortree=2265 /SigmaFactorBS="tacaggaagctgaaaacaggaaaaaaagaataatttttataa aacacacacgtttTTCAATTACAATAAGTGTAAttacgtgtgtgttttttgattttgt a" /listShort="S96, ycbL, ycbM" /GFF_Attribute="listLong" /label="upshifts" CDS 259944..260624 /gene="ycbL" /locus_tag="BSU_02550" /old_locus_tag="BSU02550" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YcbM]" /protein_id="NP_388137.2" /db_xref="EnsemblGenomes-Gn:BSU02550" /db_xref="EnsemblGenomes-Tr:CAB12049" /db_xref="GOA:P42244" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11167" /db_xref="UniProtKB/Swiss-Prot:P42244" /translation="MLVEDDHSISEMVDHYLTKEGFGIVHAFDGEEGIRLFQQGSYDL VLLDIMLPKLNGMDFLKIIREKSNIPVLMISAKDGDVDKALGLGFGADDYIAKPFSMI ELTARVKAAIRRATQYSAEEPAVNKVIRIHQLAIDIDNVSVLKNGEPLQLTSTEWQLL CLFASNPKKVFTKEQIYRSVWNEEYFDDQNIINVHMRRLREKIEDDPSSPQYIKTLWG IGYKLGEF*" /label="ycbL CDS" gene 259944..260624 /gene="ycbL" /locus_tag="BSU_02550" /old_locus_tag="BSU02550" /label="ycbL gene" CDS 260626..261561 /gene="ycbM" /locus_tag="BSU_02560" /old_locus_tag="BSU02560" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YcbL]" /protein_id="NP_388138.2" /db_xref="EnsemblGenomes-Gn:BSU02560" /db_xref="EnsemblGenomes-Tr:CAB12050" /db_xref="GOA:P42245" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11168" /db_xref="UniProtKB/Swiss-Prot:P42245" /translation="MTVLWVAAVIALACLNVIQFIMKKKRDGNLAYTADQLSYMLSRD SAGQILLPTDDHALKDLLVNINLIVENRQQISAQFAKTEQSMKRMLTNMSHDLKTPLT VILGYIEAIQSDPNMPDEERERLLGKLRQKTNELIQMINSFFDLAKLESEDKEIPITK VHMNDICKRNILHYYDAVQSKGFQAAIDIPDTPVYAQANEEALDRILQNLLSNAIQYG AAGKLIGLTLSYDERNIAITVWDRGKGISETDQQRVFERLYTLEESRNKAFQGSGLGL TITKRLTEKMGGIISVQSKPYERTAFTITLKRMTY*" /label="ycbM CDS" gene 260626..261561 /gene="ycbM" /locus_tag="BSU_02560" /old_locus_tag="BSU02560" /label="ycbM gene" CDS 261653..262576 /gene="ycbN" /locus_tag="BSU_02570" /old_locus_tag="BSU02570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC efflux transporter (ATP-binding protein)" /protein_id="NP_388139.2" /db_xref="EnsemblGenomes-Gn:BSU02570" /db_xref="EnsemblGenomes-Tr:CAB12051" /db_xref="GOA:P42246" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11169" /db_xref="UniProtKB/Swiss-Prot:P42246" /translation="MTYIVQTNGLTKTYQGKEVVSNVSMHIKKGEIYGFLGPNGAGKT TIMKMLTSLVKPTSGEIIILGNKFTHTSYEVLGNIGSMIEYPIFYENLTAEENLDLHC EYMGYHNKKAIQEVLDMVNLKQIDKKPVKTFSLGMKQRLGIARAILTKPDLLILDEPV NGLDPLGIKKIRQLFQVLSKEYGMTLLISSHLLGEIEQIADTIGVIRDGRLLEEVSME DVRGQNTEYIELVTPNQTRACFVLEKELQLTNFKILNEKTIRIYEAEASQAAISKALI LNDVDIESMNKKYTSLEDYFIKLINGNSISA*" /label="ycbN CDS" gene 261653..262576 /gene="ycbN" /locus_tag="BSU_02570" /old_locus_tag="BSU02570" /label="ycbN gene" S_feature complement(262123..263307) /Source="Nicolas_S_feature" /locus_tag="new_280556_281740_c" /HighExp="Etha, Sw, Gly, B36, LoTm, B60, GM 150, Salt, C30, ferm" /AntisenseName="ycbO" /AntisenseCor="-0.38911425676406203" /AntisenseRegPval="-10.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S97" CDS 262595..263281 /gene="ycbO" /locus_tag="BSU_02580" /old_locus_tag="BSU02580" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+-driven exporter" /protein_id="NP_388140.3" /db_xref="EnsemblGenomes-Gn:BSU02580" /db_xref="EnsemblGenomes-Tr:CAB12052" /db_xref="GOA:P42247" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11170" /db_xref="UniProtKB/Swiss-Prot:P42247" /translation="MNLIRIELRKMKMGWYIRGALIANVIIMGFMWLISYSEKADGGV SFQSTDEAFLIIGTFVRAVFIVFGAVLIVKLVISEYKNKTILVMFTYPISRKKLLTAK LMIAGGLTFITILLSNILIAAGFFWLNSICHFIPGELTSEIISQQAVKMAVFAFGAAG TSLVPIFFGMRRHSVPATIISSVVIVMLISSTSPGFSISSVVYIPLSLAAFGLFFSYM AIRNADKQDA*" /label="ycbO CDS" gene 262595..263281 /gene="ycbO" /locus_tag="BSU_02580" /old_locus_tag="BSU02580" /label="ycbO gene" CDS complement(263242..263376) /locus_tag="BSU_02585" /old_locus_tag="BSU02585" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513940.1" /translation="MARSIILKQEQTHNGKAGADSIGLLYILGAFVYASCLSAFLIAM *" /label="hypothetical protein CDS" gene complement(263242..263376) /locus_tag="BSU_02585" /old_locus_tag="BSU02585" /label="gene" downshifts 263276 /Source="Nicolas_upshifts" /id="D100" /incds=0 /nref=8 /ntot=120 /MaxReadThrough="1.13131" /MaxDrop="3.44039" /score="18.1873505" /energy="-11.4" /TU="NA" /idTUdmin="U184" /TUdmin="-1166" /isTUend="FALSE" /label="downshifts" CDS complement(263336..263722) /gene="ycbP" /locus_tag="BSU_02590" /old_locus_tag="BSU02590" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22582280; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative inner integral membrane protein" /protein_id="NP_388141.1" /db_xref="EnsemblGenomes-Gn:BSU02590" /db_xref="EnsemblGenomes-Tr:CAB12053" /db_xref="GOA:P42248" /db_xref="InterPro:IPR019649" /db_xref="SubtiList:BG11171" /db_xref="UniProtKB/Swiss-Prot:P42248" /translation="MTHVKALAIKGIMTIIVLYLVLGLGFGFTFGDTLLMTIVLGVIS YLLGDLYVLPKWNNMIATLADFGLAFLVIWLMGMPLSMGMTGGEVALAALFGAIVMAI GEYCFHFYMMSKEIGKKHYLETRTDS*" /label="ycbP CDS" gene complement(263336..263722) /gene="ycbP" /locus_tag="BSU_02590" /old_locus_tag="BSU02590" /label="ycbP gene" downshifts complement(263352) /Source="Nicolas_upshifts" /id="D101" /incds=0 /nref=148 /ntot=217 /MaxReadThrough="6.64196" /MaxDrop="7.40353" /score="13.8182557" /energy="-15.6" /TU="U183" /idTUdmin="U185" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(263748..263766) /Source="Nicolas_upshift_promotors" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(263767) /Source="Nicolas_upshifts" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(263780..263786) /Source="Nicolas_upshift_promotors" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(263800..264798) /Source="Nicolas_S_feature" /locus_tag="new_282233_283231_c" /HighExp="GM 150, T0.30H, C30, T1.30H, T1.0H, T-0.40H, T-3.40H, T2.0H, T2.30H, T-4.40H" /AntisenseName="cwlJ" /AntisenseCor="0.11463160303596701" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S98" downshifts complement(263843) /Source="Nicolas_upshifts" /id="D102" /incds=0 /nref=3 /ntot=10 /MaxReadThrough="5.23914" /MaxDrop="3.14515" /score="13.8182557" /energy="-15.6" /TU="U185,U187" /idTUdmin="U185" /TUdmin="-491" /isTUend="FALSE" /label="downshifts" promotor_-35 263979..263984 /Source="Nicolas_upshift_promotors" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 263998 /Source="Nicolas_upshifts" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 264000..264018 /Source="Nicolas_upshift_promotors" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(264012) /Source="Nicolas_upshifts" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(264014..264028) /Source="Nicolas_upshift_promotors" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(264034) /Source="Nicolas_upshifts" /id="D103" /incds=0 /nref=2 /ntot=5 /MaxReadThrough="5.64474" /MaxDrop="3.76775" /score="13.8182557" /energy="-15.6" /TU="U187" /idTUdmin="U185" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" promotor_-35 complement(264036..264040) /Source="Nicolas_upshift_promotors" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 264036..264464 /gene="cwlJ" /locus_tag="BSU_02600" /old_locus_tag="BSU02600" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9515903, 11466292, 11807087, 12177332, 16936016, 26190134, 28333204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9515903, 11466292, 11807087, 12177332, 16936016, 26190134, 28333204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore cortex cell wall hydrolase" /protein_id="NP_388142.2" /db_xref="EnsemblGenomes-Gn:BSU02600" /db_xref="EnsemblGenomes-Tr:CAB12054" /db_xref="GOA:P42249" /db_xref="InterPro:IPR011105" /db_xref="SubtiList:BG11172" /db_xref="UniProtKB/Swiss-Prot:P42249" /translation="MAVVRATSADVDLMARLLRAEAEGEGKQGMLLVGNVGINRLRAN CSDFKGLRTIRQMIYQPHAFEAVTHGYFYQRARDSERALARRSINGERRWPAKFSLWY FRPQGDCPAQWYNQPFVARFKSHCFYQPTAETCENVYNTF*" /label="cwlJ CDS" gene 264036..264464 /gene="cwlJ" /locus_tag="BSU_02600" /old_locus_tag="BSU02600" /label="cwlJ gene" downshifts 264443 /Source="Nicolas_upshifts" /id="D104" /incds=0 /nref=44 /ntot=63 /MaxReadThrough="2.30044" /MaxDrop="5.89045" /score="18.1873505" /energy="-11.4" /TU="NA" /idTUdmin="U184" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-35 264509..264515 /Source="Nicolas_upshift_promotors" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 264528..264547 /Source="Nicolas_upshift_promotors" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 264530 /Source="Nicolas_upshifts" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="upshifts" CDS 264570..265301 /gene="ycbR" /locus_tag="BSU_02610" /old_locus_tag="BSU02610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388143.2" /db_xref="EnsemblGenomes-Gn:BSU02610" /db_xref="EnsemblGenomes-Tr:CAB12055" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR019303" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG11173" /db_xref="UniProtKB/Swiss-Prot:P42250" /translation="MATIDLQKKSVKIVLEKKQLTKVTARVGLVLDITGSMRPLYKNG TVQNVVERILAVADQFDDNGLLDVWVYDNEFSRLKPVSEKDFSGYVDREILNNDRLHK FGRNDEPPVMKDVLRKYVTEEPSSYPAFIVFINDGGCKKSIKPIIEASSDKPVFWQFV GIGNGNFDFLNKLDTLEGRVIDNTNFLHIEEIDRISDDELYDALLAEFPFWLKEAKEK GIVREQEPPAEKPKKKGFFSRLFSK*" /label="ycbR CDS" gene 264570..265301 /gene="ycbR" /locus_tag="BSU_02610" /old_locus_tag="BSU02610" /label="ycbR gene" promotor_-10 complement(264772..264791) /Source="Nicolas_upshift_promotors" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(264798) /Source="Nicolas_upshifts" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(264805..264812) /Source="Nicolas_upshift_promotors" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 265219 /Source="Nicolas_upshifts" /id="D105" /incds=1 /nref=9 /ntot=148 /MaxReadThrough="1.70712" /MaxDrop="3.61288" /score="25.6672471" /energy="-14.1" /TU="NA" /idTUdmin="U186" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS 265383..265559 /gene="yczK" /locus_tag="BSU_02619" /old_locus_tag="BSU02619" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097673.1" /db_xref="EnsemblGenomes-Gn:BSU02619" /db_xref="EnsemblGenomes-Tr:CAX52543" /db_xref="UniProtKB/Swiss-Prot:C0H3T2" /translation="MGGLQTTGYAENASFSQLSACFSSRLVREDLFLMFSAYNQFTLL HSRLTMISYNGDDQ*" /label="yczK CDS" gene 265383..265559 /gene="yczK" /locus_tag="BSU_02619" /old_locus_tag="BSU02619" /label="yczK gene" promotor_-35 265511..265517 /Source="Nicolas_upshift_promotors" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 265524..265541 /Source="Nicolas_upshift_promotors" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 265535 /Source="Nicolas_upshifts" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="upshifts" CDS 265578..267329 /gene="phoD" /locus_tag="BSU_02620" /old_locus_tag="BSU02620" /EC_number="3.1.4.46" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11719524, 12867413, 16698798, 19395490, 19616508, 21479178, 27780866" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11719524, 12867413, 16698798, 19395490, 19616508, 21479178, 27780866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted phosphodiesterase (endo-hydrolysis at non-specific sites throughout the cell wall teichoic acid polymer)" /protein_id="NP_388144.2" /db_xref="EnsemblGenomes-Gn:BSU02620" /db_xref="EnsemblGenomes-Tr:CAB12056" /db_xref="GOA:P42251" /db_xref="InterPro:IPR008963" /db_xref="InterPro:IPR018946" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR032093" /db_xref="PDB:2YEQ" /db_xref="SubtiList:BG11174" /db_xref="UniProtKB/Swiss-Prot:P42251" /translation="MAYDSRFDEWVQKLKEESFQNNTFDRRKFIQGAGKIAGLSLGLT IAQSVGAFEVNAAPNFSSYPFTLGVASGDPLSDSVVLWTRLAPDPLNGGGMPKQAVPV KWEVAKDEHFRKIVRKGTEMAKPSLAHSVHVEADGLEPNKVYYYRFKTGHELSPVGKT KTLPAPGANVPQMTFAFASCQQYEHGYYTAYKHMAKEKLDLVFHLGDYIYEYGPNEYV SKTGNVRTHNSAEIITLQDYRNRHAQYRSDANLKAAHAAFPWVVTWDDHEVENNYANK IPEKGQSVEAFVLRRAAAYQAYYEHMPLRISSLPNGPDMQLYRHFTYGNLASFNVLDT RQYRDDQANNDGNKPPSDESRNPNRTLLGKEQEQWLFNNLGSSTAHWNVLAQQIFFAK WNFGTSASPIYSMDSWDGYPAQRERVINFIKSKNLNNVVVLTGDVHASWASNLHVDFE KTSSKIFGAEFVGTSITSGGNGADKRADTDQILKENPHIQFFNDYRGYVRCTVTPHQW KADYRVMPFVTEPGAAISTRASFVYQKDQTGLRKVSSTTIQGGVKQSDEVEEDRFFSH NKAHEKQMIKKRAKITN*" /label="phoD CDS" gene 265578..267329 /gene="phoD" /locus_tag="BSU_02620" /old_locus_tag="BSU02620" /label="phoD gene" promotor_-10 complement(265632..265647) /Source="Nicolas_upshift_promotors" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(265638) /Source="Nicolas_upshifts" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(265660..265669) /Source="Nicolas_upshift_promotors" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 267342..267554 /gene="tatAD" /locus_tag="BSU_02630" /old_locus_tag="BSU02630" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12867413, 15554971, 16678787, 19049517, 21479530, 27984091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12867413, 15554971, 16678787, 19049517, 21479530, 27984091; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388145.2" /db_xref="EnsemblGenomes-Gn:BSU02630" /db_xref="EnsemblGenomes-Tr:CAB12057" /db_xref="GOA:O31467" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR003998" /db_xref="InterPro:IPR006312" /db_xref="PDB:2L16" /db_xref="SubtiList:BG12777" /db_xref="UniProtKB/Swiss-Prot:O31467" /translation="MFSNIGIPGLILIFVIALIIFGPSKLPEIGRAAGRTLLEFKSAT KSLVSGDEKEEKSAELTAVKQDKNAG*" /label="tatAD CDS" gene 267342..267554 /gene="tatAD" /locus_tag="BSU_02630" /old_locus_tag="BSU02630" /label="tatAD gene" S_feature 267555..267614 /Source="Nicolas_S_feature" /locus_tag="new_285988_286047" /HighExp="LPhT, BI, Paraq, C90, H2O2, M40t90, C30, M0t90, GM 60, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0569" /TUlongSig="NA" /TUlongPSig="NA" /label="S99" CDS 267615..268343 /gene="tatCD" /locus_tag="BSU_02640" /old_locus_tag="BSU02640" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16698798, 19049517, 27984091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16698798, 19049517, 27984091; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388146.2" /db_xref="EnsemblGenomes-Gn:BSU02640" /db_xref="EnsemblGenomes-Tr:CAB12058" /db_xref="GOA:P42252" /db_xref="InterPro:IPR002033" /db_xref="InterPro:IPR019820" /db_xref="SubtiList:BG11175" /db_xref="UniProtKB/Swiss-Prot:P42252" /translation="MDKKETHLIGHLEELRRRIIVTLAAFFLFLITAFLFVQDIYDWL IRDLDGKLAVLGPSEILWVYMMLSGICAIAASIPVAAYQLWRFVAPALTKTERKVTLM YIPGLFALFLAGISFGYFVLFPIVLSFLTHLSSGHFETMFTADRYFRFMVNLSLPFGF LFEMPLVVMFLTRLGILNPYRLAKARKLSYFLLIVVSILITPPDFISDFLVMIPLLVL FEVSVTLSAFVYKKRMREETAAAA*" /label="tatCD CDS" gene 267615..268343 /gene="tatCD" /locus_tag="BSU_02640" /old_locus_tag="BSU02640" /label="tatCD gene" downshifts complement(267623) /Source="Nicolas_upshifts" /id="D106" /incds=0 /nref=4 /ntot=146 /MaxReadThrough="1.2763" /MaxDrop="3.13944" /score="-9.00478071" /energy="-8.5" /TU="NA" /idTUdmin="U190" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(268340..268987) /gene="pcp" /locus_tag="BSU_02650" /old_locus_tag="BSU02650" /EC_number="3.4.19.3" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1362573, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1362573, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrrolidone-carboxylate (pyroglutamate) peptidase" /protein_id="NP_388147.1" /db_xref="EnsemblGenomes-Gn:BSU02650" /db_xref="EnsemblGenomes-Tr:CAB12059" /db_xref="GOA:P28618" /db_xref="InterPro:IPR000816" /db_xref="InterPro:IPR016125" /db_xref="InterPro:IPR029762" /db_xref="InterPro:IPR033693" /db_xref="InterPro:IPR033694" /db_xref="InterPro:IPR036440" /db_xref="SubtiList:BG10873" /db_xref="UniProtKB/Swiss-Prot:P28618" /translation="MRKKVLITGFDPFDKETVNPSWEAAKRLNGFETEEAIITAEQIP TVFRSALDTLRQAIQKHQPDIVICVGQAGGRMQITPERVAINLADARIPDNEGHQPID EEISPDGPAAYWTRLPVKRMTAKMKEHGIPAAVSYTAGTFVCNYLFYGLMDHISRTSP HIRGGFIHIPYIPQQTIDKTAPSLSLDTIVRALRIAAVTAAQYDEDVKSPGGTLH*" /label="pcp CDS" gene complement(268340..268987) /gene="pcp" /locus_tag="BSU_02650" /old_locus_tag="BSU02650" /label="pcp gene" promotor_-10 complement(269002..269021) /Source="Nicolas_upshift_promotors" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 269015..269021 /Source="Nicolas_upshift_promotors" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(269016) /Source="Nicolas_upshifts" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(269036..269040) /Source="Nicolas_upshift_promotors" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 269036..269055 /Source="Nicolas_upshift_promotors" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 269038 /Source="Nicolas_upshifts" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="upshifts" CDS 269066..270178 /gene="ycbU" /locus_tag="BSU_02660" /old_locus_tag="BSU02660" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase (PLP-dependent)" /protein_id="NP_388148.2" /db_xref="EnsemblGenomes-Gn:BSU02660" /db_xref="EnsemblGenomes-Tr:CAB12060" /db_xref="GOA:P42253" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG11176" /db_xref="UniProtKB/Swiss-Prot:P42253" /translation="MEHLPEQYRQLFPTLQTHTMLASCSQSALAEPVSRAIQDYYDSL LYKGTNWKEAIEKTEFARNEFAKLIGAEPDEVAIVPSVSDALVSVASSLTAFGKKHVV YTDMDFPAVPHVWQAHSDYTVSVIPSIDGVLPLEQYETHISDETVLTCVPHVHYRDGY VQDIKAIAEISQRKGSLLFVDAYQSAGHIPIDVKEWGVDMLAAGTRKYLLGIPGVAFL YVRKELADALKPKASAWFGRESGFDGAYAKVARRFQTGTPAFISVYAAAAALSLLNHI GVSHIRDHVKTICADAVQYAAEKGLQLAAAQGGIQPGMVAIRDERASETAGLLKKKKV ICAPRENVIRLAPHFYNTKEEMRHAIDEIAAKTIHK*" /label="ycbU CDS" gene 269066..270178 /gene="ycbU" /locus_tag="BSU_02660" /old_locus_tag="BSU02660" /label="ycbU gene" upshifts complement(269412) /Source="Nicolas_upshifts" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(269415..269434) /Source="Nicolas_upshift_promotors" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(269450..269454) /Source="Nicolas_upshift_promotors" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 270172 /Source="Nicolas_upshifts" /id="D107" /incds=0 /nref=45 /ntot=226 /MaxReadThrough="1.10091" /MaxDrop="4.52742" /score="6.75687898" /energy="-14" /TU="NA" /idTUdmin="U191" /TUdmin=814 /isTUend="FALSE" /label="downshifts" CDS complement(270220..271659) /gene="lmrB" /locus_tag="BSU_02670" /old_locus_tag="BSU02670" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15317768, 15849754, 16850406, 17483215" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317768, 15849754, 16850406, 17483215; Product type t: transporter" /codon_start=1 /transl_table=11 /product="flavonoid efflux transporter; drug-export protein" /protein_id="NP_388149.1" /db_xref="EnsemblGenomes-Gn:BSU02670" /db_xref="EnsemblGenomes-Tr:CAB12061" /db_xref="GOA:O35018" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12613" /db_xref="UniProtKB/Swiss-Prot:O35018" /translation="MILETTAKASQQYKVMPIMISLLLAGFIGMFSETALNIALTDLM KELNITAATVQWLTTGYLLVLGILVPVSGLLLQWFTTRQLFTVSLIFSILGTFIAALA PSFSFLLAARIVQALGTGLLLPLMFNTILVIFPPHKRGAAMGTIGLVIMFAPAIGPTF SGLVLEHLNWHWIFWISLPFLVLALVFGIAYMQNVSETTKPKIDVLSIILSTIGFGGI VFGFSNAGEGSGGWSSPTVIVSLIVGVVGLILFSIRQLTMKQPMMNLRAFKYPMFILG VIMVFICMMVILSSMLLLPMYLQGGLVLTAFASGLVLLPGGILNGFMSPVTGRLFDKY GPKWLVIPGFVIVTVVLWFFSNVTTTSTAVLIIILHTCLMIGISMIMMPAQTNGLNQL PREFYPDGTAIMNTLQQMAGAIGTAVAVSIMAAGQHDYMSTVKNPADPAVIPQALTAG VQHAFVFAMIVAIIGLIGAFFMKRVKVDH*" /label="lmrB CDS" gene complement(270220..271659) /gene="lmrB" /locus_tag="BSU_02670" /old_locus_tag="BSU02670" /label="lmrB gene" downshifts complement(270227) /Source="Nicolas_upshifts" /id="D108" /incds=0 /nref=162 /ntot=245 /MaxReadThrough="0.65833" /MaxDrop="6.75228" /score="18.3484535" /energy="-14" /TU="U193" /idTUdmin="U193" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(271699..272265) /gene="lmrA" /locus_tag="BSU_02680" /old_locus_tag="BSU02680" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12718394, 15317768, 17483215" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12718394, 15317768, 17483215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of lmrAB and yxaGH operons (flavonoid and antibiotic resistance)" /protein_id="NP_388150.1" /db_xref="EnsemblGenomes-Gn:BSU02680" /db_xref="EnsemblGenomes-Tr:CAB12062" /db_xref="GOA:O34619" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12612" /db_xref="UniProtKB/Swiss-Prot:O34619" /translation="MSYGDSREKILSAATRLFQLQGYYGTGLNQIIKESGAPKGSLYY HFPGGKEQLAIEAVNEMKEYIRQKIADCMEACTDPAEGIQAFLKELSCQFSCTEDIEG LPVGLLAAETSLKSEPLREACHEAYKEWASVYEEKLRQTGCSESRAKEASTVVNAMIE GGILLSLTAKNSTPLLHISSCIPDLLKR*" /label="lmrA CDS" gene complement(271699..272265) /gene="lmrA" /locus_tag="BSU_02680" /old_locus_tag="BSU02680" /label="lmrA gene" promotor_-10 complement(272303..272322) /Source="Nicolas_upshift_promotors" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(272317) /Source="Nicolas_upshifts" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(272337..272344) /Source="Nicolas_upshift_promotors" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 272419..272425 /Source="Nicolas_upshift_promotors" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 272441..272458 /Source="Nicolas_upshift_promotors" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 272447 /Source="Nicolas_upshifts" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="upshifts" CDS 272482..273609 /gene="ansZ" /locus_tag="BSU_02690" /old_locus_tag="BSU02690" /EC_number="3.5.1.1" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11914346, 17686772" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914346, 17686772; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-asparaginase 2 (putative lipoprotein)" /protein_id="NP_388151.1" /db_xref="EnsemblGenomes-Gn:BSU02690" /db_xref="EnsemblGenomes-Tr:CAB12063" /db_xref="GOA:O34482" /db_xref="InterPro:IPR004550" /db_xref="InterPro:IPR006034" /db_xref="InterPro:IPR020827" /db_xref="InterPro:IPR027473" /db_xref="InterPro:IPR027474" /db_xref="InterPro:IPR027475" /db_xref="InterPro:IPR036152" /db_xref="InterPro:IPR037152" /db_xref="SubtiList:BG12755" /db_xref="UniProtKB/Swiss-Prot:O34482" /translation="MKKQRMLVLFTALLFVFTGCSHSPETKESPKEKAQTQKVSSASA SEKKDLPNIRILATGGTIAGADQSKTSTTEYKAGVVGVESLIEAVPEMKDIANVSGEQ IVNVGSTNIDNKILLKLAKRINHLLASDDVDGIVVTHGTDTLEETAYFLNLTVKSDKP VVIVGSMRPSTAISADGPSNLYNAVKVAGAPEAKGKGTLVVLNDRIASARYVTKTNTT TTDTFKSEEMGFVGTIADDIYFNNEITRKHTKDTDFSVSNLDELPQVDIIYGYQNDGS YLFDAAVKAGAKGIVFAGSGNGSLSDAAEKGADSAVKKGVTVVRSTRTGNGVVTPNQD YAEKDLLASNSLNPQKARMLLMLALTKTNDPQKIQAYFNEY*" /label="ansZ CDS" gene 272482..273609 /gene="ansZ" /locus_tag="BSU_02690" /old_locus_tag="BSU02690" /label="ansZ gene" downshifts 273582 /Source="Nicolas_upshifts" /id="D109" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="1.70459" /MaxDrop="4.27333" /score="23.2201078" /energy="-7.6" /TU="NA" /idTUdmin="U194" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 273706..273712 /Source="Nicolas_upshift_promotors" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 273726..273745 /Source="Nicolas_upshift_promotors" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 273726 /Source="Nicolas_upshifts" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="upshifts" CDS 273772..274410 /gene="estA" /locus_tag="BSU_02700" /old_locus_tag="BSU02700" /EC_number="3.1.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8396026, 15812018, 18053819, 11029590, 24827611, 28963005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8396026, 15812018, 18053819, 11029590, 24827611, 28963005; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="secreted alkaliphilic lipase" /protein_id="NP_388152.1" /db_xref="EnsemblGenomes-Gn:BSU02700" /db_xref="EnsemblGenomes-Tr:CAB12064" /db_xref="GOA:P37957" /db_xref="InterPro:IPR002918" /db_xref="InterPro:IPR029058" /db_xref="PDB:1I6W" /db_xref="PDB:1ISP" /db_xref="PDB:1R4Z" /db_xref="PDB:1R50" /db_xref="PDB:1T2N" /db_xref="PDB:1T4M" /db_xref="PDB:2QXT" /db_xref="PDB:2QXU" /db_xref="PDB:3D2A" /db_xref="PDB:3D2B" /db_xref="PDB:3D2C" /db_xref="PDB:3QMM" /db_xref="PDB:3QZU" /db_xref="PDB:5CRI" /db_xref="PDB:5CT4" /db_xref="PDB:5CT5" /db_xref="PDB:5CT6" /db_xref="PDB:5CT8" /db_xref="PDB:5CT9" /db_xref="PDB:5CTA" /db_xref="PDB:5CUR" /db_xref="SubtiList:BG10679" /db_xref="UniProtKB/Swiss-Prot:P37957" /translation="MKFVKRRIIALVTILMLSVTSLFALQPSAKAAEHNPVVMVHGIG GASFNFAGIKSYLVSQGWSRDKLYAVDFWDKTGTNYNNGPVLSRFVQKVLDETGAKKV DIVAHSMGGANTLYYIKNLDGGNKVANVVTLGGANRLTTGKALPGTDPNQKILYTSIY SSADMIVMNYLSRLDGARNVQIHGVGHIGLLYSSQVNSLIKEGLNGGGQNTN*" /label="estA CDS" gene 273772..274410 /gene="estA" /locus_tag="BSU_02700" /old_locus_tag="BSU02700" /label="estA gene" downshifts 274396 /Source="Nicolas_upshifts" /id="D110" /incds=0 /nref=15 /ntot=117 /MaxReadThrough="4.54554" /MaxDrop="4.10395" /score="23.2201078" /energy="-7.6" /TU="U195" /idTUdmin="U194" /TUdmin=814 /isTUend="FALSE" /label="downshifts" S_feature 274441..275031 /Source="Nicolas_S_feature" /locus_tag="new_292874_293464" /HighExp="M9-tran, GM 150, LoTm, MG 150, GM 120, aero, T-1.40H, M/G, S2, GM 90" /AntisenseName="yczC" /AntisenseCor="3.5651747957185502E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S100" CDS complement(274448..274831) /gene="yczC" /locus_tag="BSU_02710" /old_locus_tag="BSU02710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_388153.1" /db_xref="EnsemblGenomes-Gn:BSU02710" /db_xref="EnsemblGenomes-Tr:CAB12065" /db_xref="GOA:O31469" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG12778" /db_xref="UniProtKB/Swiss-Prot:O31469" /translation="MELAGFMLRACALLLDVIIAAAVILAAGFTFGDGSAGVIIVAIL MLIVYPLLMPLTNWKGTLGKKIIGLQIVRDETYKKISFPQAIVRYLIAWVHVFSRLIY LTAAFTKKKQTVHDMAAKTIVLKAE*" /label="yczC CDS" gene complement(274448..274831) /gene="yczC" /locus_tag="BSU_02710" /old_locus_tag="BSU02710" /label="yczC gene" downshifts complement(274472) /Source="Nicolas_upshifts" /id="D111" /incds=0 /nref=4 /ntot=94 /MaxReadThrough="0.85389" /MaxDrop="2.7858" /score="15.0330092" /energy="-12.1" /TU="NA" /idTUdmin="U196" /TUdmin=0 /isTUend="TRUE" /label="downshifts" Polymorphism join(274645,274647) /Source="geneious" /ID="SNP_BsDelta6_293079_293079" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position=186 /Change="C -> T" /Codon_Change="CTG -> CTA" /Coverage=154 /locus_tag="BSU_02710" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=154 /comment="silent" /modified_by="User" / /label="Polymorphism_Delta6" promotor_-10 complement(274861..274880) /Source="Nicolas_upshift_promotors" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(274868) /Source="Nicolas_upshifts" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(274894..274901) /Source="Nicolas_upshift_promotors" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 275003..275006 /Source="Nicolas_upshift_promotors" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 275022..275041 /Source="Nicolas_upshift_promotors" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 275033 /Source="Nicolas_upshifts" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="upshifts" CDS 275066..276142 /gene="yccF" /locus_tag="BSU_02720" /old_locus_tag="BSU02720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388154.1" /db_xref="EnsemblGenomes-Gn:BSU02720" /db_xref="EnsemblGenomes-Tr:CAB12066" /db_xref="GOA:O34478" /db_xref="InterPro:IPR004027" /db_xref="InterPro:IPR007889" /db_xref="InterPro:IPR036915" /db_xref="SubtiList:BG12756" /db_xref="UniProtKB/Swiss-Prot:O34478" /translation="MGKVKRNAPCPCGSGKKYKKCCGSKVVDFPAELAAKEAKQIQED LVEYAFTVHRESISGFINQHDFLSAMDRQTKDISVFNLGIWGIFFHPLAGEKTIFEEY LQKKGDSITRPKTREIVESWQSMTPALLLLKDLKEGIIHFEDVITAKQFEVEMDASNQ DLPPVGSLILGYPIHEAEKAEFFMQFTIFPVKRTEALISKVKKYADAAVKDGKTPEDF MKQEFNNVLFALLAEKDEEPQAEKAEVSTVEWANDLEKETAAAIEEGMSGEEYPTELI PAVIDIWKTFCEKKSPVIRKPEAFAAAVEYYVNAISLNGASVSQAKLAKKYGVSASTI SSRYKEIESTLQDEADRFAQALSS*" /label="yccF CDS" gene 275066..276142 /gene="yccF" /locus_tag="BSU_02720" /old_locus_tag="BSU02720" /label="yccF gene" downshifts 276136 /Source="Nicolas_upshifts" /id="D112" /incds=0 /nref=60 /ntot=248 /MaxReadThrough="1.55048" /MaxDrop="5.18328" /score="33.0000484" /energy="-12.9" /TU="NA" /idTUdmin="U197" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(276182..277138) /gene="natK" /locus_tag="BSU_02730" /old_locus_tag="BSU02730" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17322186; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [NatR]" /protein_id="NP_388155.1" /db_xref="EnsemblGenomes-Gn:BSU02730" /db_xref="EnsemblGenomes-Tr:CAB12067" /db_xref="GOA:P70954" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR032834" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11997" /db_xref="UniProtKB/Swiss-Prot:P70954" /translation="MITLFQCLYLILFSFICYQGAAAFSHSTAASWLAAALGAAAAGL YIWNTKRVWKHCSSGLCAWIAVIQVMSVGVVLIGTDIMPVLCVIAIFAGCEGLRIGQS ALQARLSDQIDKLTQAEQHANQMLIDVRSRNHDTMKHITAIKSAQPKADTQAYIQNWA DQYSQYDRFLKGENAYVAGVLYDFLEKARASNVSVSLHMHTPLSSLPFSPADQVSLVG NILENALDSAAEAREKAEIKLETSLRSGLYVLTCENSTPGMDPKVLDTIYQSFGRSTK NGAHEGMGTYIIQKLVKGAFGRLDFTYRHPIFRLEIKIPFQK*" /label="natK CDS" gene complement(276182..277138) /gene="natK" /locus_tag="BSU_02730" /old_locus_tag="BSU02730" /label="natK gene" downshifts complement(276210) /Source="Nicolas_upshifts" /id="D113" /incds=0 /nref=1 /ntot=129 /MaxReadThrough="0.86926" /MaxDrop="2.67125" /score="14.02819" /energy="-12.9" /TU="NA" /idTUdmin="U198" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS complement(277151..277852) /gene="natR" /locus_tag="BSU_02740" /old_locus_tag="BSU02740" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17322186; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [NatK]" /protein_id="NP_388156.1" /db_xref="EnsemblGenomes-Gn:BSU02740" /db_xref="EnsemblGenomes-Tr:CAB12068" /db_xref="GOA:P70955" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR007492" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11998" /db_xref="UniProtKB/Swiss-Prot:P70955" /translation="MVKVGLVDDYRVDLEKLEAIVSRMQDVEIVFSTDSAKEAYRRVK NGDIDLLLADIEMPHMSGYELADLIKSHSLDVDVIFVTGHGGYAVHAFDLNVHDYIMK PYYADRLAASFDRYLKKKTETSLNGRILIKQKSEMHVLQKKDIIFAERTGRSTTIVTT AEEVQTYQTLNDIKGDLPEKDFLRSHRSFIINIHYIKHFSAYTKHSFTVSFEGTSKKA MITKQQLDYFQNYYF*" /label="natR CDS" gene complement(277151..277852) /gene="natR" /locus_tag="BSU_02740" /old_locus_tag="BSU02740" /label="natR gene" promotor_-10 complement(277876..277895) /Source="Nicolas_upshift_promotors" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(277882) /Source="Nicolas_upshifts" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(277911..277914) /Source="Nicolas_upshift_promotors" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 277932..277935 /Source="Nicolas_upshift_promotors" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 277951..277970 /Source="Nicolas_upshift_promotors" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 277961 /Source="Nicolas_upshifts" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="upshifts" CDS 277996..278736 /gene="natA" /locus_tag="BSU_02750" /old_locus_tag="BSU02750" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10356997, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10356997, 17322186; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+ ABC efflux transporter (ATP-binding protein)" /protein_id="NP_388157.1" /db_xref="EnsemblGenomes-Gn:BSU02750" /db_xref="EnsemblGenomes-Tr:CAB12069" /db_xref="GOA:P46903" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11338" /db_xref="UniProtKB/Swiss-Prot:P46903" /translation="MITLTDCSRRFQDKKKVVKAVRDVSLTIEKGEVVGILGENGAGK TTMLRMIASLLEPSQGVITVDGFDTVKQPAEVKQRIGVLFGGETGLYDRMTAKENLQY FGRLYGLNRHEIKARIEDLSKRFGMRDYMNRRVGGFSKGMRQKVAIARALIHDPDIIL FDEPTTGLDITSSNIFREFIQQLKREQKTILFSSHIMEEVQALCDSVIMIHSGEVIYR GALESLYESERSEDLNYIFMSKLVRGIS*" /label="natA CDS" gene 277996..278736 /gene="natA" /locus_tag="BSU_02750" /old_locus_tag="BSU02750" /label="natA gene" CDS 278737..279897 /gene="natB" /locus_tag="BSU_02760" /old_locus_tag="BSU02760" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10356997, 15849754, 16850406, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10356997, 15849754, 16850406, 17322186; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+ ABC efflux transporter (permease)" /protein_id="NP_388158.1" /db_xref="EnsemblGenomes-Gn:BSU02760" /db_xref="EnsemblGenomes-Tr:CAB12070" /db_xref="GOA:P46904" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11339" /db_xref="UniProtKB/Swiss-Prot:P46904" /translation="MLSHIYKKEMIDALRDRKTILLTILVPMIMMLGLVFFYESMLSD KGEQYTLAVGHSLPPALESKLNEIDEISVKTFAKPEEAVDEGKADAYLNVPKEFDSYV NSMTPFKVDVYGNSIDQGSSNAMQLVQSALDQYKNEIVQQRLTNKHIDQSVIQPFTIQ QKEADEEKGTSAIMLSAILPMLILTSIVSGAMPIALDIMAGEKDRKSIEALLLTPVSR NKVLVGKWLAVSTFGVASGVFALVFLILSTVLFTENLKTAFQLGDHMWSVIGASALII VLSALLISAMELFISIMSSSVKEAQSYMSLVVFLPVFPMFFIFSKAPNQFDLSYFLIP FLNLHALFKQLLFGMVDPATILSTSGTIAVLIAIFFLLARACFLKDKWVLPK*" /label="natB CDS" gene 278737..279897 /gene="natB" /locus_tag="BSU_02760" /old_locus_tag="BSU02760" /label="natB gene" promotor_-35 279948..279956 /Source="Nicolas_upshift_promotors" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 279968..279986 /Source="Nicolas_upshift_promotors" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 279968 /Source="Nicolas_upshifts" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="upshifts" CDS 280033..280965 /gene="yccK" /locus_tag="BSU_02770" /old_locus_tag="BSU02770" /EC_number="1.-.-.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322186, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ion channel associated aldo-keto reductase" /protein_id="NP_388159.1" /db_xref="EnsemblGenomes-Gn:BSU02770" /db_xref="EnsemblGenomes-Tr:CAB12071" /db_xref="GOA:P46905" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11340" /db_xref="UniProtKB/Swiss-Prot:P46905" /translation="MDQTRTLGKTKLKVKRIGFGANAVGGHNLFPNLNDETGKDLVRT ALDGGVNFIDTAFIYGLGRSEELIGEVVQERGVRNELIIATKGAHKEVDGSIELDNSR EFLRSEVEKSLKRLKTDYIDLYYVHFPDGKTPLAEVAGTLKELKDEGKIKAIGASNLD YQQLQDFNADGYLEVFQAEYSLIQRDAEKELLPYCEKQGISFIPYFPLASGLLTGKFT QDTVFDDFRKDKPQFQGETFIHNLKKVDKLKAVAEEKQADTAHVALAWLLTRPAIDAI IPGAKRPEQLQDNLKTLNIELTEDEVNFISDIFK*" /label="yccK CDS" gene 280033..280965 /gene="yccK" /locus_tag="BSU_02770" /old_locus_tag="BSU02770" /label="yccK gene" CDS complement(281005..282069) /gene="ycdA" /locus_tag="BSU_02780" /old_locus_tag="BSU02780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 22496484; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein involved in swarming behaviour" /protein_id="NP_388160.1" /db_xref="EnsemblGenomes-Gn:BSU02780" /db_xref="EnsemblGenomes-Tr:CAB12072" /db_xref="GOA:O34538" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="InterPro:IPR031343" /db_xref="PDB:4R4G" /db_xref="SubtiList:BG12757" /db_xref="UniProtKB/Swiss-Prot:O34538" /translation="MFQKKTYAVFLILLLMMFTAACSGSKTSAEKKESETEKSSDIAQ VKIKDVSYTLPSKYDKSTSDDQLVLKVNVAVKNTGKDPLNVDSMDFTLYQGDTKMSDT DPEDYSEKLQGSTINADKSVEGNLFFVVDKGKQYELNYTPESYGDKKPKSVTFKIDGK DKKILATADKLQDSAKALSAYVDVLLFGKDNADFEKITGANKNEIVNDFNESAKDGYL SASGLSSTYADSKALDNIVNGIKEGLSKNSSIQAKTTSISKDEAIVEATVKPVDASSL SDRIEDKVKDYYSKNSSASYEEAVKYALQVYPEEFKKLGPASSEKTVEVKMKKNDIDQ WQLDMDDYRAAELVEAFIKE*" /label="ycdA CDS" gene complement(281005..282069) /gene="ycdA" /locus_tag="BSU_02780" /old_locus_tag="BSU02780" /label="ycdA gene" downshifts complement(281006) /Source="Nicolas_upshifts" /id="D114" /incds=0 /nref=198 /ntot=222 /MaxReadThrough="0.57029" /MaxDrop="8.85093" /score="27.0612397" /energy="-13.7" /TU="NA" /idTUdmin="U201" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(282070..282260) /Source="Nicolas_S_feature" /locus_tag="new_300503_300693_c" /HighExp="S5, S4, MG 45, MG 15, MG-0.2, MG 25, MG-0.1, MG 10, S3, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S101" CDS complement(282092..282223) /locus_tag="BSU_02785" /old_locus_tag="BSU02785" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513941.1" /translation="MTKEGGVSRKSGENREKRTDFFGYMMLIHSKRSISQRQKTPLS* " /label="hypothetical protein CDS" gene complement(282092..282223) /locus_tag="BSU_02785" /old_locus_tag="BSU02785" /label="gene" promotor_-10 complement(282245..282264) /Source="Nicolas_upshift_promotors" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(282265) /Source="Nicolas_upshifts" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(282279..282286) /Source="Nicolas_upshift_promotors" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 282397..283815 /gene="ycdB" /locus_tag="BSU_02790" /old_locus_tag="BSU02790" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388161.1" /db_xref="EnsemblGenomes-Gn:BSU02790" /db_xref="EnsemblGenomes-Tr:CAB12073" /db_xref="InterPro:IPR032599" /db_xref="SubtiList:BG12758" /db_xref="UniProtKB/Swiss-Prot:O34621" /translation="MKGAAFVKKEGLKQKALEIGRVPTHLKLEIEDYGGDDKRAHFCW ADPQDENTGIIVELGPDGELESLSRDIEPESGERLSEEKLEDIMRQFVETHHPGALSA FVREENDRAYGDKVRFSYVQMEAGLPLPMSGFMADVSLSGEIVYFRYYGEAGSIIKPK RVADVEEALAFIKKDVEFDLLFEVLHRSVYKNGDDQPHLVYEPEGRAITVPADLVQEE QAVDDDDDYREPESFPLPLFEGIREKADPDSMIGIENGFVKEREADLGDGRIGIVWRN PDDPVYQPADKSMDSWFKGRTHQVLKTIYNKETGKLEGVMSFMEKKGPLTVTLAECEK IALRFLFALFPNADQYFRIRYDEKDEEENAVAGFTFEAHCHGVPLRFGQIRICVSRQT GYITVYMGPDIDPNKLATIDPVPAISVEQAKSIFWQHFKVELGWEREYGDDEEHSYRL VYKPVYPHFIDAHTGEPVFSIW*" /label="ycdB CDS" gene 282397..283815 /gene="ycdB" /locus_tag="BSU_02790" /old_locus_tag="BSU02790" /label="ycdB gene" promotor_-10 complement(283858..283876) /Source="Nicolas_upshift_promotors" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(283866) /Source="Nicolas_upshifts" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(283890..283897) /Source="Nicolas_upshift_promotors" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 283922..284001 /Source="Nicolas_S_feature" /locus_tag="new_302355_302434" /HighExp="ferm, M40t45, M0t45, Lbstat, S0, nit, LBGtran, Lbtran, G135, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S102" upshifts 283922 /Source="Nicolas_upshifts" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="upshifts" promotor_-35 283924..283930 /Source="Nicolas_upshift_promotors" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="promotor_-35" promotor_-10 283945..283962 /Source="Nicolas_upshift_promotors" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="promotor_-10" CDS 284002..285363 /gene="ycdC" /locus_tag="BSU_02800" /old_locus_tag="BSU02800" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388162.1" /db_xref="EnsemblGenomes-Gn:BSU02800" /db_xref="EnsemblGenomes-Tr:CAB12074" /db_xref="InterPro:IPR032599" /db_xref="SubtiList:BG12759" /db_xref="UniProtKB/Swiss-Prot:O34772" /translation="MVNKQLKKKAQEIGNVPTHYELEIEDYDQKQKKYGQAYFIWKDP KDPEKHITVELRNDGALLTFSTTVHSETDKKLPDAELKLTALQFAAANHPGTFMNFHF QGKEERGQHIRFVYTKMELGLPIPNSGFLIDMTRSGQIVHFLYYGEGHKAEVPTEFVA KEKVVSHYLNTMSFELMYDVIDGEQEPRLVYEPILPGYSYPADVDEIVPDQHIADERI ENTAPLPPLQNKEEVDIFALLGFTSDMQKVSERDFGEQIGSTWRRGAAPERKDLSIGS YFETRNKNTIKMKTDKRTGKLKAALSFMDWRNNLQCSTEECQEIALQFLYALYPRAAE FFRVNPVRIDERGRVRNHFSVWYKGVPLRFGAARIIVNPETGLIDAFMAPDIEPEQLE AINHRPDVSAEEAKEAFLAAFDVKLEWQPDFTAGSDQHCKLVYKPVYPSYIDAHIRKK KRL*" /label="ycdC CDS" gene 284002..285363 /gene="ycdC" /locus_tag="BSU_02800" /old_locus_tag="BSU02800" /label="ycdC gene" S_feature 285364..285944 /Source="Nicolas_S_feature" /locus_tag="new_303797_304377" /HighExp="ferm, M0t45, G135, G180, H2O2, M40t45, G150, Paraq, S0, nit" /AntisenseName="cwlK" /AntisenseCor="0.27553388443794402" /AntisenseRegPval="-5.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S103" CDS complement(285371..285874) /gene="cwlK" /locus_tag="BSU_02810" /old_locus_tag="BSU02810" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17588176" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17588176; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="murein L,D:-endopeptidase" /protein_id="NP_388163.1" /db_xref="EnsemblGenomes-Gn:BSU02810" /db_xref="EnsemblGenomes-Tr:CAB12075" /db_xref="GOA:O34360" /db_xref="InterPro:IPR009045" /db_xref="SubtiList:BG12760" /db_xref="UniProtKB/Swiss-Prot:O34360" /translation="MNLPAKTFVILCILFLLDLCFSYIRHEWHSQNALQDMPVPSDLH PIVKQNADALKAAAANKGIDVVITEGFRSFKEQDELYKQGRTKKGNIVTYARGGESYH NYGLAIDFALQKKDGSIIWDMEYDGNQNGKSDWLEVVEIAKTLGFEWGGDWKRFKDYP HLEMIPN*" /label="cwlK CDS" gene complement(285371..285874) /gene="cwlK" /locus_tag="BSU_02810" /old_locus_tag="BSU02810" /label="cwlK gene" S_feature complement(285875..285956) /Source="Nicolas_S_feature" /locus_tag="new_304308_304389_c" /HighExp="Cold, T0.30H, LBGstat, C30, T-0.40H, T1.0H, T1.30H, H2O2, T0.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S104" upshifts 285946 /Source="Nicolas_upshifts" /id="U204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2275 /SigmaFactorBS="tttctcaagatgtgctgaatgttaacgcttttaagtgattga ctctctctaaaagcgaacagcTATGATAAAATATAACATAAatagtagcaggaggaag g" /listShort="rapJ" /listLong="ycdF, ycdG, adcA, adcC, adcB" /label="upshifts" promotor_-10 complement(285948..285967) /Source="Nicolas_upshift_promotors" /id="U205" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.946053946053946" /xcortree=2433 /SigmaFactorBS="tgatggaatctttgctctcatcggtctgcctccttccTcctg ctactattTATGTTATATTTTATCATAGctgttcgcttttagagagagtcaatcactt a" /listShort="S104, cwlK" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 285949..285968 /Source="Nicolas_upshift_promotors" /id="U204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2275 /SigmaFactorBS="tttctcaagatgtgctgaatgttaacgcttttaagtgattga ctctctctaaaagcgaacagcTATGATAAAATATAACATAAatagtagcaggaggaag g" /listShort="rapJ" /listLong="ycdF, ycdG, adcA, adcC, adcB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(285957) /Source="Nicolas_upshifts" /id="U205" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.946053946053946" /xcortree=2433 /SigmaFactorBS="tgatggaatctttgctctcatcggtctgcctccttccTcctg ctactattTATGTTATATTTTATCATAGctgttcgcttttagagagagtcaatcactt a" /listShort="S104, cwlK" /GFF_Attribute="listLong" /label="upshifts" CDS 285997..287118 /gene="rapJ" /locus_tag="BSU_02820" /old_locus_tag="BSU02820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16816200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16816200; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_388164.1" /db_xref="EnsemblGenomes-Gn:BSU02820" /db_xref="EnsemblGenomes-Tr:CAB12076" /db_xref="GOA:O34327" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:4GYO" /db_xref="SubtiList:BG12663" /db_xref="UniProtKB/Swiss-Prot:O34327" /translation="MRAKIPSEEVAVKLNEWYKLIRAFEADQAEALKQEIEYDLEDME ENQDLLLYFSLMEFRHRIMLDKLMPVKDSDTKPPFSDMLNEIESNQQKLTGLLEYYFY YFRGMYEFKQKNFILAIDHYKHAEEKLEYVEDEIEKAEFLFKVAEVYYHIKQTYFSMN YASQALDIYTKYELYGRRRVQCEFIIAGNLTDVYHHEKALTHLCSALEHARQLEEAYM IAAAYYNVGHCKYSLGDYKEAEGYFKTAAAIFEEHNFQQAVQAVFSLTHIYCKEGKYD KAVEAYDRGIKSAAEWEDDMYLTKFRLIHELYLGSGDLNVLTECFDLLESRQLLADAE DLLHDTAERFNQLEHYESAAFFYRRLMNIKKKLAEQRFQ*" /label="rapJ CDS" gene 285997..287118 /gene="rapJ" /locus_tag="BSU_02820" /old_locus_tag="BSU02820" /label="rapJ gene" downshifts 287112 /Source="Nicolas_upshifts" /id="D115" /incds=0 /nref=88 /ntot=228 /MaxReadThrough="3.8438" /MaxDrop="5.06867" /score="32.2653577" /energy="-13.2" /TU="U204" /idTUdmin="U204" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-35 287159..287165 /Source="Nicolas_upshift_promotors" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 287180..287198 /Source="Nicolas_upshift_promotors" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 287183 /Source="Nicolas_upshifts" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="upshifts" CDS 287225..288001 /gene="ycdF" /locus_tag="BSU_02830" /old_locus_tag="BSU02830" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 11948145, 15805528; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388165.1" /db_xref="EnsemblGenomes-Gn:BSU02830" /db_xref="EnsemblGenomes-Tr:CAB12077" /db_xref="GOA:P80869" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12761" /db_xref="UniProtKB/Swiss-Prot:P80869" /translation="MYKDLTGKTAIVTGSSKGIGKAIAERFGKEKMNVVVNYHSDPSG ADETLEIIKQNGGKAVSVEADVSKEEGIQALLDTALEHFGTLDVMVNNSGFNGVEAMP HEMSLEDWQRVIDVNVTGTFLGAKAALNHMMKNNIKGNVLNISSVHQQIPRPVNVQYS TSKGGIKMMTETLALNYADKGIRVNAIAPGTIATESNVDTKKEESRQKQLKKIPMKAF GKPEEVAAAAAWLVSEEASYVTGATLFVDGGMTLYPSQLE*" /label="ycdF CDS" gene 287225..288001 /gene="ycdF" /locus_tag="BSU_02830" /old_locus_tag="BSU02830" /label="ycdF gene" downshifts complement(287232) /Source="Nicolas_upshifts" /id="D116" /incds=0 /nref=10 /ntot=23 /MaxReadThrough="0.31912" /MaxDrop="4.8095" /score="0.506500496" /energy="-5.8" /TU="NA" /idTUdmin="U205" /TUdmin="-1914" /isTUend="FALSE" /label="downshifts" CDS 288026..289711 /gene="ycdG" /locus_tag="BSU_02840" /old_locus_tag="BSU02840" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544224; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oligo-carbohydrate hydrolase" /protein_id="NP_388166.1" /db_xref="EnsemblGenomes-Gn:BSU02840" /db_xref="EnsemblGenomes-Tr:CAB12078" /db_xref="GOA:O34364" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12762" /db_xref="UniProtKB/Swiss-Prot:O34364" /translation="MKTDWWKDAVVYQIYPRSFQDSNGDGIGDLRGIISRLDYIKELG ADVIWICPIYPSPNVDYGYDVTNHKAIMDSYGTMDDFHELLDQVHQRGLKLVMDFVLN HTSVEHPWFKEAELDKNSKYRSYYYWRPGTKNGPPTDWLSNYGCPVWQYEEHTGEYYL HMNAVKQADLNWENPEVRQAVYDMMKFWLDKGVDGLRIDQLHLISKKEYLPSYEDYIN QQAEPKPFQPNGERIHDYLKEITDEVFSHYDVMSVGEVGSVTPEEGLKYTGTDKHELN MIFHFQHMELDQQPGKEHWDLKPLELSDLKSVLTKWQKKLEHQGWNTLFWCNHDQPRI VSRFGDDGEYRKASAKMLAAVIYFMKGTPYIYQGEEIGMTNAPFTRIEDYKDIQTINM YHKRVFEKGYDPNDVMRSILAKSRDHARTPMQWNSGKNAGFTDGTPWLKVNPNFTAIN VEEAQGDPDSVLNYYKKLISLRKQYADLMKGSFDLLLPDDPQLFVYMRENSKQQLLSV NNFSKEQAVFQWPKNCGKAQASLLLSNYNNDDLDDEMVFRPYESRVYLLDKTN*" /label="ycdG CDS" gene 288026..289711 /gene="ycdG" /locus_tag="BSU_02840" /old_locus_tag="BSU02840" /label="ycdG gene" promotor_no_box 288966..289066 /Source="Nicolas_upshift_promotors" /id="U207" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.487512487512487" /psig="0.044955044955045" /xcortree=117 /SigmaFactorBS="agaagcttgaacatcaaggctggaatacattgttttggtgca accacgaccagccccggattgtgtccagattcggagacgatggggaataccgcaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 289026 /Source="Nicolas_upshifts" /id="U207" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.487512487512487" /psig="0.044955044955045" /xcortree=117 /SigmaFactorBS="agaagcttgaacatcaaggctggaatacattgttttggtgca accacgaccagccccggattgtgtccagattcggagacgatggggaataccgcaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 289092 /Source="Nicolas_upshifts" /id="D117" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="7.77365" /MaxDrop="2.18547" /score="23.9074448" /energy="-10.2" /TU="U206" /idTUdmin="U204" /TUdmin=1914 /isTUend="FALSE" /label="downshifts" downshifts 289708 /Source="Nicolas_upshifts" /id="D118" /incds=0 /nref=13 /ntot=56 /MaxReadThrough="5.8252" /MaxDrop="5.18702" /score="23.9074448" /energy="-10.2" /TU="U206" /idTUdmin="U204" /TUdmin=2530 /isTUend="FALSE" /label="downshifts" promotor_-35 289802..289809 /Source="Nicolas_upshift_promotors" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 289825..289844 /Source="Nicolas_upshift_promotors" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 289831 /Source="Nicolas_upshifts" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="upshifts" CDS 289899..290858 /gene="znuA" /locus_tag="BSU_02850" /old_locus_tag="BSU02850" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9379902, 12426338, 14730579, 21813502; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="Zn(II)-binding lipoprotein" /protein_id="NP_388167.1" /db_xref="EnsemblGenomes-Gn:BSU02850" /db_xref="EnsemblGenomes-Tr:CAB12079" /db_xref="GOA:O34966" /db_xref="InterPro:IPR006127" /db_xref="InterPro:IPR006128" /db_xref="InterPro:IPR006129" /db_xref="PDB:2O1E" /db_xref="SubtiList:BG12763" /db_xref="UniProtKB/Swiss-Prot:O34966" /translation="MFKKWSGLFVIAACFLLVAACGNSSTKGSADSKGDKLHVVTTFY PMYEFTKQIVKDKGDVDLLIPSSVEPHDWEPTPKDIANIQDADLFVYNSEYMETWVPS AEKSMGQGHAVFVNASKGIDLMEGSEEEHEEHDHGEHEHSHAMDPHVWLSPVLAQKEV KNITAQIVKQDPDNKEYYEKNSKEYIAKLQDLDKLYRTTAKKAEKKEFITQHTAFGYL AKEYGLKQVPIAGLSPDQEPSAASLAKLKTYAKEHNVKVIYFEEIASSKVADTLASEI GAKTEVLNTLEGLSKEEQDKGLGYIDIMKQNLDALKDSLLVKS*" /label="znuA CDS" gene 289899..290858 /gene="znuA" /locus_tag="BSU_02850" /old_locus_tag="BSU02850" /label="znuA gene" promotor_-35 290454..290460 /Source="Nicolas_upshift_promotors" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 290474..290493 /Source="Nicolas_upshift_promotors" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 290478 /Source="Nicolas_upshifts" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="upshifts" downshifts 290830 /Source="Nicolas_upshifts" /id="D119" /incds=0 /nref=140 /ntot=250 /MaxReadThrough="6.07181" /MaxDrop="5.15011" /score="8.99106569" /energy="-15.9" /TU="U206,U208,U209" /idTUdmin="U206" /TUdmin="-1562" /isTUend="FALSE" /label="downshifts" CDS 290914..291609 /gene="znuC" /locus_tag="BSU_02860" /old_locus_tag="BSU02860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9379902, 9811636, 21813502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9379902, 9811636, 21813502; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Zn(II) transporter (ATP-binding protein)" /protein_id="NP_388168.1" /db_xref="EnsemblGenomes-Gn:BSU02860" /db_xref="EnsemblGenomes-Tr:CAB12080" /db_xref="GOA:O34946" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12764" /db_xref="UniProtKB/Swiss-Prot:O34946" /translation="MNLVSLKDIVFGYSHTPVLDKVSLDIESGEFVGITGPNGASKST LIKVMLGMLKPWEGTVTISKRNTEGKRLTIGYVPQQISSFNAGFPSTVLELVQSGRYT KGKWFKRLNEEDHLEVEKALKMVEMWDLRHRKIGDLSGGQKQKICIARMLASNPDLLM LDEPTTAVDYDSRKGFYEFMHHLVKNHNRTVVMVTHEQNEVQQFLDKVIRLERGEKGG WKCLTWNSCDELF*" /label="znuC CDS" gene 290914..291609 /gene="znuC" /locus_tag="BSU_02860" /old_locus_tag="BSU02860" /label="znuC gene" CDS 291567..292409 /gene="znuB" /locus_tag="BSU_02870" /old_locus_tag="BSU02870" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 9379902, 9811636, 21813502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 9379902, 9811636, 21813502; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity Zn(II) ABC transporter (permease)" /protein_id="NP_388169.1" /db_xref="EnsemblGenomes-Gn:BSU02870" /db_xref="EnsemblGenomes-Tr:CAB12081" /db_xref="GOA:O34610" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12765" /db_xref="UniProtKB/Swiss-Prot:O34610" /translation="MEMFDLEFMRRAFLAGGMIAVMAPILGVYLVLRRQALMADTLSH ISLSGVAIGFFLSTNITAASIVVVTIGAIGIEYMRRAYRTYSEVSIAILMAAGLSFAM FLISLSKGTANMSIDQYLFGSLVTVNQQQVYIISIITLLILLYFIVLRRPLYLLTFDE ATAKTSGINTNVLSLSFSIVTGLAISVIIPIIGVLLVSALLVLPAAFAIRIAKGFNMV FITAILISLFSVFTGLTSSYQLGTPPGPSITLLLIVLLLIGFAVQGVWTFIKKEAQRK KRSR*" /label="znuB CDS" gene 291567..292409 /gene="znuB" /locus_tag="BSU_02870" /old_locus_tag="BSU02870" /label="znuB gene" downshifts 292396 /Source="Nicolas_upshifts" /id="D120" /incds=0 /nref=168 /ntot=266 /MaxReadThrough="2.4865" /MaxDrop="6.44929" /score="27.8218406" /energy="-13.6" /TU="NA" /idTUdmin="U206" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(292447..293442) /gene="yceB" /locus_tag="BSU_02880" /old_locus_tag="BSU02880" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16428414; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative luciferase-like monooxygenase" /protein_id="NP_388170.2" /db_xref="EnsemblGenomes-Gn:BSU02880" /db_xref="EnsemblGenomes-Tr:CAB12082" /db_xref="GOA:O34504" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG12766" /db_xref="UniProtKB/Swiss-Prot:O34504" /translation="MIHLSILDQAPVSKGESPVTTLQHSVELAQLSEQWGYKRYWFAE HHSTKGLASTAPEIMIARIAAQTNTIRVGSGGVLLPQYSPFKVAETFRQLEALYPNRI DLGVGRSPGGTTKTRLALTDGVKKSLTEFNRQLQDVSYFLTDSLPPDHPYAGIKAAPL IGTAPELWVLGLGENSARRAAHQGIGYVFGHFINPERGENAFRIYRESFRPSAHFSNP SALFTIFVICAKTDEEAEELALSQDLWLLRVGKGLDSRVPSIEEAKAHPYTASDKKLI EENRKRMVIGSPTTVKQQLLDLTGCYETNEIMVLCNVFDFEAKKESYERLAELFL*" /label="yceB CDS" gene complement(292447..293442) /gene="yceB" /locus_tag="BSU_02880" /old_locus_tag="BSU02880" /label="yceB gene" promotor_-35 293398..293405 /Source="Nicolas_upshift_promotors" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="promotor_-35" promotor_-10 293420..293439 /Source="Nicolas_upshift_promotors" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="promotor_-10" S_feature 293426..293628 /Source="Nicolas_S_feature" /locus_tag="new_311859_312061" /HighExp="Diami, Etha, dia5, Salt, H2O2, dia15, Paraq, T-0.40H, T0.30H, G135" /AntisenseName="yceB" /AntisenseCor="0.84300534435872998" /AntisenseRegPval="-73.099999999999994" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S105" upshifts 293426 /Source="Nicolas_upshifts" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="upshifts" promotor_-10 complement(293474..293493) /Source="Nicolas_upshift_promotors" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(293482) /Source="Nicolas_upshifts" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(293508..293515) /Source="Nicolas_upshift_promotors" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 293612..293621 /Source="Nicolas_upshift_promotors" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 293630..293725 /Source="Nicolas_S_feature" /locus_tag="new_312063_312158" /HighExp="T0.0H, T-0.40H, T-1.10H, T0.30H, Salt, T1.0H, Etha, T-1.40H, T1.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S106" upshifts 293630 /Source="Nicolas_upshifts" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 293634..293649 /Source="Nicolas_upshift_promotors" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 293726..294325 /gene="yceC" /locus_tag="BSU_02890" /old_locus_tag="BSU02890" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388171.1" /db_xref="EnsemblGenomes-Gn:BSU02890" /db_xref="EnsemblGenomes-Tr:CAB12083" /db_xref="GOA:P81100" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12767" /db_xref="UniProtKB/Swiss-Prot:P81100" /translation="MAISLEKGQRIDLTKGKAGLSKLMVGLGWDPVSSGGGFFSKLLG GGGPNIDCDASVLMLENGKFTDKKNLIYFGNLKSRCGGVQHTGDNLTGDGAGDDEQIM IDLDKVPGNIDKLVFVVNIYDCVRRKQDFGMIQNAFIRVVDQSNHEEMLKYNLRDNYA GRTSLITAEIYRSGSEWKFAAVGEGTNDTRLEDIISRYV*" /label="yceC CDS" gene 293726..294325 /gene="yceC" /locus_tag="BSU_02890" /old_locus_tag="BSU02890" /label="yceC gene" CDS 294347..294928 /gene="yceD" /locus_tag="BSU_02900" /old_locus_tag="BSU02900" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388172.1" /db_xref="EnsemblGenomes-Gn:BSU02900" /db_xref="EnsemblGenomes-Tr:CAB12084" /db_xref="GOA:P80875" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12768" /db_xref="UniProtKB/Swiss-Prot:P80875" /translation="MTISLAKGQKVDLTKTNPGLSKVVVGLGWDTNKYDGGHDFDLDS SVFLLDAAGKCASPNDFIFYNQLEGGNGSVVHSGDNLTGAGEGDDENVKVNLSAVPAN IDKISFVITIHDAEARSQNFGQVSNAFVRIVNEETNEELIRYDLAEDFSIETAIIAGE LYRHNGEWKFSAIGSGYQGGLARIATDYGLQVG*" /label="yceD CDS" gene 294347..294928 /gene="yceD" /locus_tag="BSU_02900" /old_locus_tag="BSU02900" /label="yceD gene" CDS 294963..295541 /gene="yceE" /locus_tag="BSU_02910" /old_locus_tag="BSU02910" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250, 25355936; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388173.1" /db_xref="EnsemblGenomes-Gn:BSU02910" /db_xref="EnsemblGenomes-Tr:CAB12085" /db_xref="GOA:O34384" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12769" /db_xref="UniProtKB/Swiss-Prot:O34384" /translation="MAIQLSKGQRIDLTKTNPGLTKAVIGLGWDTNKYSGGHDFDLDA SAFLVDAHDNCVNDLDFVFYNNLEHPSGGVIHTGDNRTGEGDGDDEQIIVDFSKIPAH IEKIGITVTIHDAEARSQNFGQVSNAFVRVVDEETQNELLRFDLGEDFSIETAVVVCE LYRHGGEWKFNAIGSGFSGGLAALCRNYGLQV*" /label="yceE CDS" gene 294963..295541 /gene="yceE" /locus_tag="BSU_02910" /old_locus_tag="BSU02910" /label="yceE gene" CDS 295592..296365 /gene="yceF" /locus_tag="BSU_02920" /old_locus_tag="BSU02920" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 24366250; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative stress adaptation transporter (tellurite resistance)" /protein_id="NP_388174.1" /db_xref="EnsemblGenomes-Gn:BSU02920" /db_xref="EnsemblGenomes-Tr:CAB12086" /db_xref="GOA:O34447" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022493" /db_xref="SubtiList:BG12770" /db_xref="UniProtKB/Swiss-Prot:O34447" /translation="MDFLHHILSTYASFFDWKMWGEVLTDPVSWGLIGSLVVLEGLLS ADNALVLAVMVKHLPEKQRKKALTYGLFGAYIFRFIFIGLGMLLIKFWWIKVLGALYL AWLVIKHFWIGEKEEEADGMKKNSWMVRTFGIFWATVISVELMDLAFSVDSILAAFAV SEKVWVLLIGGMLGILMMRTVAKVFLVLIDKIPELENTAFVLIGIIALKMAGSAFHYE MPHSVFFIIIIAAFAVTLIIHYINKQKQVREQTAASKEE*" /label="yceF CDS" gene 295592..296365 /gene="yceF" /locus_tag="BSU_02920" /old_locus_tag="BSU02920" /label="yceF gene" downshifts 296352 /Source="Nicolas_upshifts" /id="D121" /incds=0 /nref=46 /ntot=239 /MaxReadThrough="6.82513" /MaxDrop="4.0674" /score="4.0495978" /energy="-8.2" /TU="U212" /idTUdmin="U210" /TUdmin=2728 /isTUend="FALSE" /label="downshifts" CDS 296450..298063 /gene="yceG" /locus_tag="BSU_02930" /old_locus_tag="BSU02930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxic compound adaptation protein (tellurite resistance)" /protein_id="NP_388175.1" /db_xref="EnsemblGenomes-Gn:BSU02930" /db_xref="EnsemblGenomes-Tr:CAB12087" /db_xref="InterPro:IPR025647" /db_xref="SubtiList:BG12771" /db_xref="UniProtKB/Swiss-Prot:O34809" /translation="MRQEELTIHKALPADGDWKSLLFQPLPERDHYETAQGLSFSRLA GQILGTPIDETDYYNELYELSVNDRITILSETLDKTIEPETFQKLQHIHSINQKEKGL SVSRFVAFLDGEKLIAKHSNPLMHRHLRKALMTLLHTFADSHEKGLNHPDFRRVLLDV SKFSLNHLNPWLEKTDIEREMPKVVWYGDATKSQLYFLYYLMLVGCDVLLFHPAGTDQ LALVDPKQELGFTEKLPDVSELQPFPKEKPDRKSTVAYRSTKEIEHVLNHEESMLYKP WQFRDHTPVSVTLKTTYDELFLITKERAFIRPNFKADKHSIEIPNVFAKIMGVSKDNK EYWNRLHTLADYQETEMVRSFPFTEEIKSNYQFHYSHALDQEGNIDPDKLMASNVWQY KQLPAGVQTAIAKTISRMCRYPRLKALHQEQVKDVQIYLFKQTTNLPANLLKLIQMFD YAQTVPKLVLYHTEMSGGLTRSDAAALLFLNEIGIDIIIYNPPGHQDIEQFIEEDQYD IHWLDDMVFQQDYKEPSLVKRLFRTITQK*" /label="yceG CDS" gene 296450..298063 /gene="yceG" /locus_tag="BSU_02930" /old_locus_tag="BSU02930" /label="yceG gene" CDS 298079..299170 /gene="yceH" /locus_tag="BSU_02940" /old_locus_tag="BSU02940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative reactive oxygen species resistance protein" /protein_id="NP_388176.1" /db_xref="EnsemblGenomes-Gn:BSU02940" /db_xref="EnsemblGenomes-Tr:CAB12088" /db_xref="InterPro:IPR008863" /db_xref="SubtiList:BG12772" /db_xref="UniProtKB/Swiss-Prot:O34833" /translation="MTTENQNPLVLDKNEEISQQKADDIRLQLRQEPEVKRLAQQIDV KNQMELLEYGKEPAVEISKFSDRILGMMKTTSVTDSGTMLTQLGKIMDRFDKNDFDEP KGLMAKIFKRGGSMIEKIFKKYQTLGGEIEKIHVEISKYKDEMTKTNYTLDEMYENNI KYYMELEKYVVAGQMKLEEMQSILPSYEEKAASGNQLAQMQLDTLRNGIQALEERVYD LDMARMVALQTAPQIRLLQRGNAKLIGKINSAFIITIPIFKNGIIQAVTVKRQKLVAD SMSELDRRTNEMLKRNAENISSQSVEIARMAGRPSIDIETIESSWNTIVSGMQETKQI EEENKRLREDGARRIAQLQDNIKKAALQQ*" /label="yceH CDS" gene 298079..299170 /gene="yceH" /locus_tag="BSU_02940" /old_locus_tag="BSU02940" /label="yceH gene" downshifts 299144 /Source="Nicolas_upshifts" /id="D122" /incds=0 /nref=85 /ntot=228 /MaxReadThrough="4.46836" /MaxDrop="4.05585" /score="-6.59172775" /energy="-17.5" /TU="U212" /idTUdmin="U212" /TUdmin="-1322" /isTUend="FALSE" /label="downshifts" promotor_-35 299224..299231 /Source="Nicolas_upshift_promotors" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 299246..299265 /Source="Nicolas_upshift_promotors" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 299254 /Source="Nicolas_upshifts" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="upshifts" CDS 299292..300494 /gene="niaP" /locus_tag="BSU_02950" /old_locus_tag="BSU02950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18276644, 21953179" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18276644, 21953179; Product type t: transporter" /codon_start=1 /transl_table=11 /product="niacin permease" /protein_id="NP_388177.1" /db_xref="EnsemblGenomes-Gn:BSU02950" /db_xref="EnsemblGenomes-Tr:CAB12089" /db_xref="GOA:O34691" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12773" /db_xref="UniProtKB/Swiss-Prot:O34691" /translation="MGKQQPISQRKLLGVAGLGWLFDAMDVGILSFIIAALHVEWNLS PEEMKWIGSVNSIGMAAGAFLFGLLADRIGRKKVFIITLLCFSIGSGISAFVTSLSAF LILRFVIGMGLGGELPVASTLVSEAVVPEKRGRVIVLLESFWAVGWLAAALISYFVIP SFGWQAALLLTALTAFYALYLRTSLPDSPKYESLSAKKRSMWENVKSVWARQYIRPTV MLSIVWFCVVFSYYGMFLWLPSVMLLKGFSMIQSFEYVLLMTLAQLPGYFSAAWLIEK AGRKWILVVYLIGTAGSAYFFGTADSLSLLLTAGVLLSFFNLGAWGVLYAYTPEQYPT AIRATGSGTTAAFGRIGGIFGPLLVGTLAARHISFSVIFSIFCIAILLAVACILIMGK ETKQTELE*" /label="niaP CDS" gene 299292..300494 /gene="niaP" /locus_tag="BSU_02950" /old_locus_tag="BSU02950" /label="niaP gene" downshifts 300474 /Source="Nicolas_upshifts" /id="D123" /incds=0 /nref=8 /ntot=184 /MaxReadThrough="4.1968" /MaxDrop="3.48367" /score="13.0427769" /energy="-10.6" /TU="U213" /idTUdmin="U212" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(300747..301919) /gene="yceJ" /locus_tag="BSU_02960" /old_locus_tag="BSU02960" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative carbohydrate transporter (possibly exporter)" /protein_id="NP_388178.1" /db_xref="EnsemblGenomes-Gn:BSU02960" /db_xref="EnsemblGenomes-Tr:CAB12090" /db_xref="GOA:O34724" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12774" /db_xref="UniProtKB/Swiss-Prot:O34724" /translation="MNRIWLFFSVMFVIGTDTFLLSPLLPLLQDQFHVSTDLSGWMVS AYALGYALFAFIAGPISDRLNRKTVMLWGLAGFIVSTFLCGIAPSFAAMCLFRFAAGV SAAFVTPQIWASIPVIVQPSQIIKGMGIATAGLAASQMLGLPIGGFLASFTWHTPFFV LSACSLILLLILAAVMPGIRPSEPLARPSIVNPYRELFSLPKTSVILLAYFLFQTGNF ASFSFLGTWLSADYHLTVSQIGAAMLVLGLGNMLGSLIGSRVSEKLGMFKTLISGMLL MGALYFALPFFPNLFLVEAGFFLTFFTAGIIFPLMMGVFQSIAPNARGTIASLSNAAM YAGTTVGTSIAGFLYQSTQHFGAVTGFTAILFILSMTLYQTISKTGKRQSTARAQL*" /label="yceJ CDS" gene complement(300747..301919) /gene="yceJ" /locus_tag="BSU_02960" /old_locus_tag="BSU02960" /label="yceJ gene" downshifts complement(300762) /Source="Nicolas_upshifts" /id="D124" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="2.6211" /MaxDrop="2.7452" /score="9.21991741" /energy="-12.6" /TU="NA" /idTUdmin="U214" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(301988..302290) /gene="yceK" /locus_tag="BSU_02970" /old_locus_tag="BSU02970" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (ArsR family)" /protein_id="NP_388179.1" /db_xref="EnsemblGenomes-Gn:BSU02970" /db_xref="EnsemblGenomes-Tr:CAB12091" /db_xref="GOA:O34464" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12775" /db_xref="UniProtKB/Swiss-Prot:O34464" /translation="MYYSFMTMKQSDDQIRAQIFKALSDESRLAIIRTLYVSGKELSC GEVGEKCNIVKTTASYHFKTLREAGLTATRKDSRTKYVSLREDTFQTYLPGFLETL*" /label="yceK CDS" gene complement(301988..302290) /gene="yceK" /locus_tag="BSU_02970" /old_locus_tag="BSU02970" /label="yceK gene" downshifts complement(302016) /Source="Nicolas_upshifts" /id="D125" /incds=0 /nref=221 /ntot=261 /MaxReadThrough="5.67096" /MaxDrop="6.89889" /score="2.01231069" /energy="-4.8" /TU="U214" /idTUdmin="U214" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(302273..302292) /Source="Nicolas_upshift_promotors" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(302292) /Source="Nicolas_upshifts" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(302306..302312) /Source="Nicolas_upshift_promotors" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 302539..302558 /Source="Nicolas_upshift_promotors" /id="U215" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.99100899100899" /xcortree=2422 /SigmaFactorBS="gtttataaagaaatggtacagaataaaagagaatatgctgtt tgtgtgggaagttacataAATGTTACGGTAATAAAGATtgcttaatatggagggaaaa t" /listShort="opuAA, opuAB, opuAC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 302539 /Source="Nicolas_upshifts" /id="U215" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.99100899100899" /xcortree=2422 /SigmaFactorBS="gtttataaagaaatggtacagaataaaagagaatatgctgtt tgtgtgggaagttacataAATGTTACGGTAATAAAGATtgcttaatatggagggaaaa t" /listShort="opuAA, opuAB, opuAC" /GFF_Attribute="listLong" /label="upshifts" CDS 302580..303836 /gene="opuAA" /locus_tag="BSU_02980" /old_locus_tag="BSU02980" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7622480, 16225868, 16645306, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7622480, 16225868, 16645306, 25012968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporter(ATP-binding protein)" /protein_id="NP_388180.2" /db_xref="EnsemblGenomes-Gn:BSU02980" /db_xref="EnsemblGenomes-Tr:CAB12092" /db_xref="GOA:P46920" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11370" /db_xref="UniProtKB/Swiss-Prot:P46920" /translation="MSVDEKPIKIKVEKVSKIFGKQTKKAVQMLANGKTKKEILKATG STVGVNQADFEVYDGEIFVIMGLSGSGKSTLVRMLNRLIEPTAGNIYIDGDMITNMSK DQLREVRRKKISMVFQKFALFPHRTILENTEYGLELQGVDKQERQQKALESLKLVGLE GFEHQYPDQLSGGMQQRVGLARALTNDPDILLMDEAFSALDPLIRKDMQDELLDLHDN VGKTIIFITHDLDEALRIGDRIVLMKDGNIVQIGTPEEILMNPSNEYVEKFVEDVDLS KVLTAGHIMKRAETVRIDKGPRVALTLMKNLGISSIYAVDKQKKLLGVIYASDAKKAA ESDLSLQDILNTEFTTVPENTYLTEIFDVVSDANIPIAVVDEKQRMKGIVVRGALIGA LAGNNEYINAEGTNEQTQDPSAQEVK*" /label="opuAA CDS" gene 302580..303836 /gene="opuAA" /locus_tag="BSU_02980" /old_locus_tag="BSU02980" /label="opuAA gene" downshifts complement(302588) /Source="Nicolas_upshifts" /id="D126" /incds=0 /nref=108 /ntot=175 /MaxReadThrough="2.83797" /MaxDrop="5.18503" /score="2.01231069" /energy="-4.8" /TU="NA" /idTUdmin="U214" /TUdmin="-1826" /isTUend="FALSE" /label="downshifts" CDS 303838..304686 /gene="opuAB" /locus_tag="BSU_02990" /old_locus_tag="BSU02990" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752321, 15849754, 16225868, 16645306, 16850406, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752321, 15849754, 16225868, 16645306, 16850406, 25012968; Product type t : transporter" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporter(permease)" /protein_id="NP_388181.1" /db_xref="EnsemblGenomes-Gn:BSU02990" /db_xref="EnsemblGenomes-Tr:CAB12093" /db_xref="GOA:P46921" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11371" /db_xref="UniProtKB/Swiss-Prot:P46921" /translation="MDRLPRIPLADIIDRFVDWITMTFGGFFDGIANGLAAFVNGIVT GLGFIPSILLTIIFAALAWWISTRGIALFTLIGFLLIDYLGYWDPMLQTLALVLTSVI ISIVVGVPIGIWASQKETVRRIVTPILDLMQTMPAFVYLLPAIFFFNIGVVPGVVASV IFAMPPTIRMTVLGIKQVPADLIEATEAFGSTTAQRLFKVQLPLATKTILAGINQSIM LALSMVVIAAMVGAPGLGSEVYSAVTQLKTGVGVEAGIAIVIVAITLDRITQNIKVKK KSRGNA*" /label="opuAB CDS" gene 303838..304686 /gene="opuAB" /locus_tag="BSU_02990" /old_locus_tag="BSU02990" /label="opuAB gene" CDS 304686..305567 /gene="opuAC" /locus_tag="BSU_03000" /old_locus_tag="BSU03000" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7622480, 16225868, 16645306, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7622480, 16225868, 16645306, 25012968; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporterABC transporter (glycine betaine-binding lipoprotein)" /protein_id="NP_388182.1" /db_xref="EnsemblGenomes-Gn:BSU03000" /db_xref="EnsemblGenomes-Tr:CAB12094" /db_xref="GOA:P46922" /db_xref="InterPro:IPR007210" /db_xref="PDB:2B4L" /db_xref="PDB:2B4M" /db_xref="PDB:3CHG" /db_xref="SubtiList:BG11372" /db_xref="UniProtKB/Swiss-Prot:P46922" /translation="MLKKIIGIGVSAMLALSLAACGSENDENASAAEQVNKTIIGIDP GSGIMSLTDKAMKDYDLNDWTLISASSAAMTATLKKSYDRKKPIIITGWTPHWMFSRY KLKYLDDPKQSYGSAEEIHTITRKGFSKEQPNAAKLLSQFKWTQDEMGEIMIKVEEGE KPAKVAAEYVNKHKDQIAEWTKGVQKVKGDKINLAYVAWDSEIASTNVIGKVLEDLGY EVTLTQVEAGPMWTAIATGSADASLSAWLPNTHKAYAAKYKGKYDDIGTSMTGVKMGL VVPQYMKNVNSIEDLKK*" /label="opuAC CDS" gene 304686..305567 /gene="opuAC" /locus_tag="BSU_03000" /old_locus_tag="BSU03000" /label="opuAC gene" downshifts 305548 /Source="Nicolas_upshifts" /id="D127" /incds=0 /nref=254 /ntot=269 /MaxReadThrough="0.74967" /MaxDrop="8.21394" /score="33.6263027" /energy="-12.2" /TU="NA" /idTUdmin="U215" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(305580) /Source="Nicolas_upshifts" /id="D128" /incds=0 /nref=2 /ntot=62 /MaxReadThrough="4.29566" /MaxDrop="3.9514" /score="29.8489328" /energy="-12.2" /TU="U216" /idTUdmin="U216" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(305605..306756) /gene="amhX" /locus_tag="BSU_03010" /old_locus_tag="BSU03010" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8768514; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidohydrolase" /protein_id="NP_388183.2" /db_xref="EnsemblGenomes-Gn:BSU03010" /db_xref="EnsemblGenomes-Tr:CAB12095" /db_xref="GOA:P54983" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11789" /db_xref="UniProtKB/Swiss-Prot:P54983" /translation="MQKLSEEMKQTIMDIFEHLHANPEVSWKEYETTSFLKQKLEDLG CRTRTFSDCTGVVGEIGSGSPVVAVRADIDALWQEVNGTFRANHSCGHDSHMTMALGT LMLLKKQPELPKGTIRFIFQPAEEKGGGALKMIEEGVLDDIDYLYGVHVRPIQETQNG RCAPSILHGSSQHIEGTIIGEEAHGARPHLGKNSIEIAAFLVHKLGLIHIDPQIPHTV KMTKLQAGGESSNIIPGKASFSLDLRAQTNEAMEALIAETERACEAAAAAFGAKIELH KEHSLPAATQNKEAEAIMAEAITEIIGAERLDDPLVTTGGEDFHFYAVKVPNLKTTML GLGCGLQPGLHHPHMTFDRNAMFTGIHILANAVLKTFQKAESLAAANAS*" /label="amhX CDS" gene complement(305605..306756) /gene="amhX" /locus_tag="BSU_03010" /old_locus_tag="BSU03010" /label="amhX gene" downshifts complement(305624) /Source="Nicolas_upshifts" /id="D129" /incds=0 /nref=2 /ntot=70 /MaxReadThrough="4.33606" /MaxDrop="3.5225" /score="29.8489328" /energy="-12.2" /TU="U216" /idTUdmin="U216" /TUdmin="-264" /isTUend="FALSE" /label="downshifts" S_feature complement(306757..306844) /Source="Nicolas_S_feature" /locus_tag="new_325190_325277_c" /HighExp="Etha, T1.30H, M9-stat, T2.30H, S1, T3.30H, T5.0H, T4.0H, Sw, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S107" promotor_-35 306812..306819 /Source="Nicolas_upshift_promotors" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="promotor_-35" promotor_-10 complement(306831..306850) /Source="Nicolas_upshift_promotors" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 306834..306853 /Source="Nicolas_upshift_promotors" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="promotor_-10" upshifts complement(306844) /Source="Nicolas_upshifts" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="upshifts" upshifts 306847 /Source="Nicolas_upshifts" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="upshifts" promotor_-35 complement(306863..306869) /Source="Nicolas_upshift_promotors" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 306906..308339 /gene="ycgA" /locus_tag="BSU_03020" /old_locus_tag="BSU03020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21747963, 21764931; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative branched chain amino acid permease" /protein_id="NP_388184.2" /db_xref="EnsemblGenomes-Gn:BSU03020" /db_xref="EnsemblGenomes-Tr:CAB12096" /db_xref="GOA:P55908" /db_xref="InterPro:IPR018385" /db_xref="SubtiList:BG11999" /db_xref="UniProtKB/Swiss-Prot:P55908" /translation="MSMPAAETQPKKKRMTFKMPDAYVLLFMIAFICAIASYIVPAGE FDRVTKGDVTTAVPGSYHSIEQSPVRLISFFTSLQDGMVGSAPIIFLILFTGGTIAIL EKTGAINGLIYNVISKFRTKQLLFICIVGALFSILGTTGIVVNSVIGFIPIGLIVARS LKWDAVAGAAVIYIGCYAGFNSTILSPSPLGLSQSIAELPLFSGIGLRVVIYICFLLS SIIYIYLYTRKLKKSKDASVLGTDWFPAAGMGEAGKEEDQSVPFTVRHKLILAVAGLS LVGFLYGALKLGWSDSQMAATFIFISVLAGLIGGLAANDIAKTFITGCQSLVYGALIV GMARSISVILENGKLLDTVVNALASLLDGFSPIAGAIGMYIASALLHFLISSGSGEAV VFIPILAPLADLMGITRQVAVEAVMLGEGVVNCVNPTSGVLMAVLAASGIPYVKWLRF MVPLALIWFLIGLVFIVIGVMINWGPF*" /label="ycgA CDS" gene 306906..308339 /gene="ycgA" /locus_tag="BSU_03020" /old_locus_tag="BSU03020" /label="ycgA gene" promotor_-35 307644..307652 /Source="Nicolas_upshift_promotors" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 307664..307682 /Source="Nicolas_upshift_promotors" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 307683 /Source="Nicolas_upshifts" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 308321 /Source="Nicolas_upshifts" /id="D130" /incds=0 /nref=1 /ntot=74 /MaxReadThrough="3.53497" /MaxDrop="3.31444" /score="12.0135493" /energy="-15.6" /TU="U217" /idTUdmin="U218" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 308382..308389 /Source="Nicolas_upshift_promotors" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 308404..308423 /Source="Nicolas_upshift_promotors" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 308413 /Source="Nicolas_upshifts" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="upshifts" CDS 308455..309036 /gene="ycgB" /locus_tag="BSU_03030" /old_locus_tag="BSU03030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406, 22720735; Producttype m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_388185.2" /db_xref="EnsemblGenomes-Gn:BSU03030" /db_xref="EnsemblGenomes-Tr:CAB12097" /db_xref="SubtiList:BG12000" /db_xref="UniProtKB/Swiss-Prot:P55909" /translation="MNNLRNRLSGVNGKNKRVKEKEQKIWSEIGMIAGAFALLDVIIR GIMFEFPFKEWAASLVFLFIIILYYCIRAAASGMLMPRIDTKEELQKRVKQQRIESIA VAFAVVVLTMYDRGIPHTFFAWLKMILLFIVCGGVLFLLRYVIVKLAYRRAVKEEIKK KSSFLFGKRGKRSQFRAAFFIGTLICIHSAKLF*" /label="ycgB CDS" gene 308455..309036 /gene="ycgB" /locus_tag="BSU_03030" /old_locus_tag="BSU03030" /label="ycgB gene" upshifts 308849 /Source="Nicolas_upshifts" /id="U220" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.288711288711289" /psig="0.241758241758242" /xcortree=1550 /SigmaFactorBS="tgtacgacagggggattccccatacattcttcgcttggctga aaatgattcttctttttatcgtCTGCGgcggcgttctgtttctgcttcggtatgtgat t" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="upshifts" misc_feature 308853..308857 /Source="Nicolas_upshift_promotors" /id="U220" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.288711288711289" /psig="0.241758241758242" /xcortree=1550 /SigmaFactorBS="tgtacgacagggggattccccatacattcttcgcttggctga aaatgattcttctttttatcgtCTGCGgcggcgttctgtttctgcttcggtatgtgat t" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 309012..309019 /Source="Nicolas_upshift_promotors" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 309034..309053 /Source="Nicolas_upshift_promotors" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 309047..309184 /Source="Nicolas_S_feature" /locus_tag="new_327480_327617" /HighExp="BC, M0t90, M40t90, S2, M9-stat, T4.0H, Sw, T3.30H, Lbtran, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.999, 0.242, 0.999" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S108" upshifts 309047 /Source="Nicolas_upshifts" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="upshifts" CDS 309185..311164 /gene="amyE" /locus_tag="BSU_03040" /old_locus_tag="BSU03040" /EC_number="3.2.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3117969, 9353930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3117969, 9353930; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-amylase" /protein_id="NP_388186.2" /db_xref="EnsemblGenomes-Gn:BSU03040" /db_xref="EnsemblGenomes-Tr:CAB12098" /db_xref="GOA:P00691" /db_xref="InterPro:IPR006046" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR031319" /db_xref="InterPro:IPR031965" /db_xref="PDB:1BAG" /db_xref="PDB:1UA7" /db_xref="SubtiList:BG10473" /db_xref="UniProtKB/Swiss-Prot:P00691" /translation="MFAKRFKTSLLPLFAGFLLLFHLVLAGPAAASAETANKSNELTA PSIKSGTILHAWNWSFNTLKHNMKDIHDAGYTAIQTSPINQVKEGNQGDKSMSNWYWL YQPTSYQIGNRYLGTEQEFKEMCAAAEEYGIKVIVDAVINHTTSDYAAISNEVKSIPN WTHGNTQIKNWSDRWDVTQNSLLGLYDWNTQNTQVQSYLKRFLDRALNDGADGFRFDA AKHIELPDDGSYGSQFWPNITNTSAEFQYGEILQDSASRDAAYANYMDVTASNYGHSI RSALKNRNLGVSNISHYASDVSADKLVTWVESHDTYANDDEESTWMSDDDIRLGWAVI ASRSGSTPLFFSRPEGGGNGVRFPGKSQIGDRGSALFEDQAITAVNRFHNVMAGQPEE LSNPNGNNQIFMNQRGSHGVVLANAGSSSVSINTATKLPDGRYDNKAGAGSFQVNDGK LTGTINARSVAVLYPDDIAKAPHVFLENYKTGVTHSFNDQLTITLRADANTTKAVYQI NNGPETAFKDGDQFTIGKGDPFGKTYTIMLKGTNSDGVTRTEKYSFVKRDPASAKTIG YQNPNHWSQVNAYIYKHDGSRVIELTGSWPGKPMTKNADGIYTLTLPADTDTTNAKVI FNNGSAQVPGQNQPGFDYVLNGLYNDSGLSGSLPH*" /label="amyE CDS" gene 309185..311164 /gene="amyE" /locus_tag="BSU_03040" /old_locus_tag="BSU03040" /label="amyE gene" downshifts 311178 /Source="Nicolas_upshifts" /id="D131" /incds=0 /nref=57 /ntot=131 /MaxReadThrough="1.64783" /MaxDrop="6.55823" /score="-8.82332571" /energy="-3.4" /TU="U221" /idTUdmin="U219" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 311244..311251 /Source="Nicolas_upshift_promotors" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 311261 /Source="Nicolas_upshifts" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 311265..311284 /Source="Nicolas_upshift_promotors" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 311341..312306 /gene="lctE" /locus_tag="BSU_03050" /old_locus_tag="BSU03050" /EC_number="1.1.1.27" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10809684, 16207915, 19383131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 16207915, 19383131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-lactate dehydrogenase" /protein_id="NP_388187.2" /db_xref="EnsemblGenomes-Gn:BSU03050" /db_xref="EnsemblGenomes-Tr:CAB12099" /db_xref="GOA:P13714" /db_xref="InterPro:IPR001236" /db_xref="InterPro:IPR001557" /db_xref="InterPro:IPR011304" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR018177" /db_xref="InterPro:IPR022383" /db_xref="InterPro:IPR036291" /db_xref="PDB:3PQD" /db_xref="PDB:3PQE" /db_xref="PDB:3PQF" /db_xref="SubtiList:BG19003" /db_xref="UniProtKB/Swiss-Prot:P13714" /translation="MMNKHVNKVALIGAGFVGSSYAFALINQGITDELVVIDVNKEKA MGDVMDLNHGKAFAPQPVKTSYGTYEDCKDADIVCICAGANQKPGETRLELVEKNLKI FKGIVSEVMASGFDGIFLVATNPVDILTYATWKFSGLPKERVIGSGTTLDSARFRFML SEYFGAAPQNVHAHIIGEHGDTELPVWSHANVGGVPVSELVEKNDAYKQEELDQIVDD VKNAAYHIIEKKGATYYGVAMSLARITKAILHNENSILTVSTYLDGQYGADDVYIGVP AVVNRGGIAGITELNLNEKEKEQFLHSAGVLKNILKPHFAEQKVN*" /label="lctE CDS" gene 311341..312306 /gene="lctE" /locus_tag="BSU_03050" /old_locus_tag="BSU03050" /label="lctE gene" CDS 312338..313963 /gene="lctP" /locus_tag="BSU_03060" /old_locus_tag="BSU03060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10809684, 15849754, 16428414, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 15849754, 16428414, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-lactate permease" /protein_id="NP_388188.2" /db_xref="EnsemblGenomes-Gn:BSU03060" /db_xref="EnsemblGenomes-Tr:CAB12100" /db_xref="GOA:P55910" /db_xref="InterPro:IPR003804" /db_xref="SubtiList:BG12001" /db_xref="UniProtKB/Swiss-Prot:P55910" /translation="MWEQLYDPFGNEYVSALVALTPILFFLLALTVLKMKGILAAFLT LAVSFFVSVWAFHMPVEKAISSVLLGIGSGLWPIGYIVLMAVWLYKIAVKTGKFTIIR SSIAGISPDQRLQLLLIGFCFNAFLEGAAGFGVPIAISAALLVELGFKPLKAAALCLI ANAASGAFGAIGIPVITGAQIGDLSALELSRTLMWTLPMISFLIPFLLVFLLDRMKGI KQTWPALLVVSGGYTAVQTLTMAVLGPELANILAALFSMGGLALFLRKWQPKEIYREE GAGDAGEKKAYRAADIAKAWSPFYILTAAITIWSLPAFKALFQEGGLLYQSTLLFKMP FLHQQIMKMPPIAPSAMPLDAVFKVDLLSATGTAILAAVIVTGLFSKKFSSRDAFASL KETGKELWVPIMTICFVMGFANLANFAGLSSSIGLALAKTGDLFPFVSPVLGWIGVFI TGSVVSNNALFGHLQVVTGAQIGAGSDLLLAANTAGGVMAKLVSPQSIAIAAAAVGQT GKESKLFKRTVAYSLILLLIICIWTFILARLGV*" /label="lctP CDS" gene 312338..313963 /gene="lctP" /locus_tag="BSU_03060" /old_locus_tag="BSU03060" /label="lctP gene" downshifts 312344 /Source="Nicolas_upshifts" /id="D132" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="8.56142" /MaxDrop="2.8862" /score="-8.82332571" /energy="-3.4" /TU="U222" /idTUdmin="U221" /TUdmin=1144 /isTUend="FALSE" /label="downshifts" downshifts 313950 /Source="Nicolas_upshifts" /id="D133" /incds=0 /nref=51 /ntot=118 /MaxReadThrough="2.31168" /MaxDrop="7.73065" /score="39.575264" /energy="-15.6" /TU="NA" /idTUdmin="U222" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(314008..315546) /gene="mdr" /locus_tag="BSU_03070" /old_locus_tag="BSU03070" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9023234, 15489457, 15849754, 16850406, 21690368" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023234, 15489457, 15849754, 16850406, 21690368; Product type t : transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_388189.2" /db_xref="EnsemblGenomes-Gn:BSU03070" /db_xref="EnsemblGenomes-Tr:CAB12101" /db_xref="GOA:P96712" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12002" /db_xref="UniProtKB/Swiss-Prot:P96712" /translation="MDTTTAKQASTKFVVLGLLLGILMSAMDNTIVATAMGNIVADLG SFDKFAWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLIFFLIGSALCGIAQTMNQ LIIFRAIQGIGGGALLPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGAIIT DSISWHWVFYINVPIGALSLFFIIRYYKESLEHRKQKIDWGGAITLVVSIVCLMFALE LGGKTYDWNSIQIIGLFIVFAVFFIAFFIVERKAEEPIISFWMFKNRLFATAQILAFL YGGTFIILAVFIPIFVQAVYGSSATSAGFILTPMMIGSVIGSMIGGIFQTKASFRNLM LISVIAFFIGMLLLSNMTPDTARVWLTVFMMISGFGVGFNFSLLPAASMNDLEPRFRG TANSTNSFLRSFGMTLGVTIFGTVQTNVFTNKLNDAFSGMKGSAGSGAAQNIGDPQEI FQAGTRSQIPDAILNRIIDAMSSSITYVFLLALIPIVLAAVTILFMGKARVKTTAEMT KKAN*" /label="mdr CDS" gene complement(314008..315546) /gene="mdr" /locus_tag="BSU_03070" /old_locus_tag="BSU03070" /label="mdr gene" downshifts complement(314026) /Source="Nicolas_upshifts" /id="D134" /incds=0 /nref=70 /ntot=182 /MaxReadThrough="1.04964" /MaxDrop="4.53635" /score="30.8374042" /energy="-15.6" /TU="NA" /idTUdmin="U225" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(314600..314700) /Source="Nicolas_upshift_promotors" /id="U223" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1728 /SigmaFactorBS="attttagcggtatttattccgattttcgttcaggcggtctac ggcagctcggcgacaagcgcgggcttcattctgacgccgatgatgattggatcagtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(314640) /Source="Nicolas_upshifts" /id="U223" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1728 /SigmaFactorBS="attttagcggtatttattccgattttcgttcaggcggtctac ggcagctcggcgacaagcgcgggcttcattctgacgccgatgatgattggatcagtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 315560..315564 /Source="Nicolas_upshift_promotors" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 315580..315599 /Source="Nicolas_upshift_promotors" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 315594 /Source="Nicolas_upshifts" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(315626..315645) /Source="Nicolas_upshift_promotors" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(315629) /Source="Nicolas_upshifts" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="upshifts" CDS 315659..316123 /gene="ycgE" /locus_tag="BSU_03080" /old_locus_tag="BSU03080" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388190.2" /db_xref="EnsemblGenomes-Gn:BSU03080" /db_xref="EnsemblGenomes-Tr:CAB12102" /db_xref="GOA:O31472" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12003" /db_xref="UniProtKB/Swiss-Prot:O31472" /translation="MSTRNSRSELEKTAVQLFRKLGTRTVLFHQAAAQALGLFPTDLK SADILNEAGPMTAGELGKKTGLSTGSVTALVDRLEKAGYVAREKDPNDRRRVVIVPLT ASKKHIKDLFRPLSESTMDLCREYTEEELELIFSFVGKAADIMEEELERLKQ*" /label="ycgE CDS" gene 315659..316123 /gene="ycgE" /locus_tag="BSU_03080" /old_locus_tag="BSU03080" /label="ycgE gene" promotor_-35 complement(315660..315666) /Source="Nicolas_upshift_promotors" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 316133..316138 /Source="Nicolas_upshift_promotors" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 316154..316172 /Source="Nicolas_upshift_promotors" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 316164 /Source="Nicolas_upshifts" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="upshifts" CDS 316197..316826 /gene="ycgF" /locus_tag="BSU_03090" /old_locus_tag="BSU03090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid export permease" /protein_id="NP_388191.1" /db_xref="EnsemblGenomes-Gn:BSU03090" /db_xref="EnsemblGenomes-Tr:CAB12103" /db_xref="GOA:P94381" /db_xref="InterPro:IPR001123" /db_xref="SubtiList:BG12004" /db_xref="UniProtKB/Swiss-Prot:P94381" /translation="MNIFLSYIVLGLSLSAPVGPVNAAQIDKGIKNGFWHAWIFGLGA MTADGLYMLFIYFGLSQFLTAPFVKTFLWLFGFFVLTYTGIETLKNVREPMDVRSSRG KPSYRKTFASGFLISLSNPLSILFWLGIYGSILAKTAEAYNMNQLLIYSSGIMIGILI WDFCMAITASTFRNLLHEKLLRGLTGIAGVSLLVFGFYFGYQGIKQLLG*" /label="ycgF CDS" gene 316197..316826 /gene="ycgF" /locus_tag="BSU_03090" /old_locus_tag="BSU03090" /label="ycgF gene" promotor_-35 316837..316846 /Source="Nicolas_upshift_promotors" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 316860..316879 /Source="Nicolas_upshift_promotors" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 316868 /Source="Nicolas_upshifts" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="upshifts" CDS 316896..317657 /gene="ycgG" /locus_tag="BSU_03100" /old_locus_tag="BSU03100" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (similar to phage protein)" /protein_id="NP_388192.2" /db_xref="EnsemblGenomes-Gn:BSU03100" /db_xref="EnsemblGenomes-Tr:CAB12104" /db_xref="InterPro:IPR014988" /db_xref="SubtiList:BG12005" /db_xref="UniProtKB/Swiss-Prot:P94382" /translation="MVNGIYTKSFLERIQEELPEWQRIAFELLAETLGDDADTFPCIP GRQAFLTDQLRIAFAGDPRENRTAEELAPLLAEYGKISRDTGKYASLVVLFDTPEDLA EHYSIEAYEELFWRFLNRLSHQDEKEWPEDIPADPEHYKWEFCFDGEPYFILCATPGH EARRSRSFPFFMVTFQPRWVFDDLNGSTAFGRNMSRLIRSRLEAYDQAPIHPQLGWYG GKDNREWKQYFLRDDEKQVSKCPFSYLKNMFNKMK*" /label="ycgG CDS" gene 316896..317657 /gene="ycgG" /locus_tag="BSU_03100" /old_locus_tag="BSU03100" /label="ycgG gene" S_feature complement(317296..317658) /Source="Nicolas_S_feature" /locus_tag="new_335729_336091_c" /HighExp="S8, S7, S5, S6, S4, nit, ferm, BT, Pyr, G/S" /AntisenseName="ycgG" /AntisenseCor="0.73875580854115197" /AntisenseRegPval="-46.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S109" downshifts 317654 /Source="Nicolas_upshifts" /id="D135" /incds=0 /nref=21 /ntot=174 /MaxReadThrough="1.53211" /MaxDrop="4.92685" /score="6.36985882" /energy="-8.6" /TU="NA" /idTUdmin="U227" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(317659..318999) /gene="ycgH" /locus_tag="BSU_03110" /old_locus_tag="BSU03110" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid transporter" /protein_id="NP_388193.2" /db_xref="EnsemblGenomes-Gn:BSU03110" /db_xref="EnsemblGenomes-Tr:CAB12105" /db_xref="GOA:P94383" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12006" /db_xref="UniProtKB/Swiss-Prot:P94383" /translation="MSQTKKDQPKGNLAWWQLSLIGVGCTIGTGFFLGSSIAIVKSGF SVLLSFLIAGIGTYFVFEQLAKLSAKQPEKGSFCAYARKAFGKWAGFSNGWVYWTSEM LITGSQLTAISLFTKHWFPQVPLWVFASIYAVLGLLIIFTGLSVFEKTENVLAVIKTA AIFMFIVIAILALCGILSGGNHGIHVPNKTSEFFPYGAMGLWTGLIYAFYAFGGIEVM GLMAVHLKKPEEASKSGKLMLATLAIIYIISIGLALLLVPLHTFTEQDSPFITSLKGY NLEIILDIFNGIFIIAGFSTLVASLFAVTTLLCTMADDGDAPKCFTLKEGKKICWPAL GLTFAGLVLSIILSLVLPKNIYEHMTTAAGLMLLYTWLFILFSSKKLTDPEGMGKTQI YLAMVLIAAAVSGTLFEKSSRPGFFVSIGFLVIIAIVTMIYQKKQGHKDRPASP*" /label="ycgH CDS" gene complement(317659..318999) /gene="ycgH" /locus_tag="BSU_03110" /old_locus_tag="BSU03110" /label="ycgH gene" promotor_-10 complement(319026..319037) /Source="Nicolas_upshift_promotors" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(319036) /Source="Nicolas_upshifts" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(319052..319058) /Source="Nicolas_upshift_promotors" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 319078..319084 /Source="Nicolas_upshift_promotors" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 319092 /Source="Nicolas_upshifts" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 319099..319110 /Source="Nicolas_upshift_promotors" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 319129..319725 /gene="ycgI" /locus_tag="BSU_03120" /old_locus_tag="BSU03120" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 16433904, 28898812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xenotiotic metabolite methyltransferase" /protein_id="NP_388194.3" /db_xref="EnsemblGenomes-Gn:BSU03120" /db_xref="EnsemblGenomes-Tr:CAB12106" /db_xref="InterPro:IPR018959" /db_xref="SubtiList:BG12007" /db_xref="UniProtKB/Swiss-Prot:O31473" /translation="MTQQYIVEPKKGLGLKLKKGQILKVVDVEGQQVADFVAYHAKDF YEHLDQGATIDANHSIHVKVNDHLYSNLYKPMLTLIEDTVGKHDLLLPACRPDMNRLL YGKQKDEFQDTCYDNMNRALEQFGVPKPHMHYPFAIFMNTVLDEKGNLSVETPLSNAG DYVRLRAEMDLIVAFSSCPIEKGKCNGDSVTSIRVEVS*" /label="ycgI CDS" gene 319129..319725 /gene="ycgI" /locus_tag="BSU_03120" /old_locus_tag="BSU03120" /label="ycgI gene" promotor_-35 319733..319740 /Source="Nicolas_upshift_promotors" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 319754..319854 /Source="Nicolas_S_feature" /locus_tag="new_338187_338287" /HighExp="dia15, LBGtran, dia5, Etha, dia0, LBGexp, M0t45, Lbexp, Diami, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S110" promotor_-10 319754..319773 /Source="Nicolas_upshift_promotors" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 319754 /Source="Nicolas_upshifts" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(319850) /Source="Nicolas_upshifts" /id="D136" /incds=0 /nref=3 /ntot=24 /MaxReadThrough="1.2989" /MaxDrop="4.67402" /score="15.0992897" /energy="-14.1" /TU="NA" /idTUdmin="U233" /TUdmin=1562 /isTUend="FALSE" /label="downshifts" CDS 319855..320673 /gene="nadE" /locus_tag="BSU_03130" /old_locus_tag="BSU03130" /EC_number="6.3.1.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7890752, 9271869, 12682299, 19204287" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7890752, 9271869, 12682299, 19204287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ammonium-dependent NAD+ synthetase" /protein_id="NP_388195.1" /db_xref="EnsemblGenomes-Gn:BSU03130" /db_xref="EnsemblGenomes-Tr:CAB12107" /db_xref="GOA:P08164" /db_xref="InterPro:IPR003694" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR022310" /db_xref="InterPro:IPR022926" /db_xref="PDB:1EE1" /db_xref="PDB:1FYD" /db_xref="PDB:1IFX" /db_xref="PDB:1IH8" /db_xref="PDB:1KQP" /db_xref="PDB:1NSY" /db_xref="PDB:2NSY" /db_xref="SubtiList:BG10694" /db_xref="UniProtKB/Swiss-Prot:P08164" /translation="MSMQEKIMRELHVKPSIDPKQEIEDRVNFLKQYVKKTGAKGFVL GISGGQDSTLAGRLAQLAVESIREEGGDAQFIAVRLPHGTQQDEDDAQLALKFIKPDK SWKFDIKSTVSAFSDQYQQETGDQLTDFNKGNVKARTRMIAQYAIGGQEGLLVLGTDH AAEAVTGFFTKYGDGGADLLPLTGLTKRQGRTLLKELGAPERLYLKEPTADLLDEKPQ QSDETELGISYDEIDDYLEGKEVSAKVSEALEKRYSMTEHKRQVPASMFDDWWK*" /label="nadE CDS" gene 319855..320673 /gene="nadE" /locus_tag="BSU_03130" /old_locus_tag="BSU03130" /label="nadE gene" downshifts 320655 /Source="Nicolas_upshifts" /id="D137" /incds=0 /nref=144 /ntot=271 /MaxReadThrough="2.68866" /MaxDrop="6.24927" /score="20.6612287" /energy="-14.1" /TU="U230" /idTUdmin="U230" /TUdmin="-65" /isTUend="FALSE" /label="downshifts" CDS complement(320723..321316) /gene="tmrB" /locus_tag="BSU_03140" /old_locus_tag="BSU03140" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1624425, 7766032, 15131133, 27315722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1624425, 7766032, 15131133, 27315722; Product type f: factor" /codon_start=1 /transl_table=11 /product="ATP-binding tunicamycin resistance protein" /protein_id="NP_388196.2" /db_xref="EnsemblGenomes-Gn:BSU03140" /db_xref="EnsemblGenomes-Tr:CAB12108" /db_xref="GOA:P12921" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10456" /db_xref="UniProtKB/Swiss-Prot:P12921" /translation="MIIWINGAFGSGKTQTAFELHRRLNPSYVYDPEKMGFALRSMVP QEIAKDDFQSYPLWRAFNYSLLASLTDTYRGILIVPMTIVHPEYFNEIIGRLRQEGRI VHHFTLMASKETLLKRLRTRAEGKNSWAAKQIDRCVEGLSSPIFEDHIQTDNLSIQDV AENIAARAELPLDPDTRGSLRRFADRLMVKLNHIRIK*" /label="tmrB CDS" gene complement(320723..321316) /gene="tmrB" /locus_tag="BSU_03140" /old_locus_tag="BSU03140" /label="tmrB gene" downshifts complement(320730) /Source="Nicolas_upshifts" /id="D138" /incds=0 /nref=10 /ntot=143 /MaxReadThrough="0.60282" /MaxDrop="3.74815" /score="15.0992897" /energy="-14.1" /TU="NA" /idTUdmin="U233" /TUdmin=682 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(321331..321350) /Source="Nicolas_upshift_promotors" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(321346) /Source="Nicolas_upshifts" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(321365..321368) /Source="Nicolas_upshift_promotors" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(321374..321522) /Source="Nicolas_S_feature" /locus_tag="new_339807_339955_c" /HighExp="S4, S3, S6, S5, S7, BT, S8, LoTm, T5.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S111" promotor_-35 321424..321431 /Source="Nicolas_upshift_promotors" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 321444..321463 /Source="Nicolas_upshift_promotors" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 321446..321554 /Source="Nicolas_S_feature" /locus_tag="new_339879_339987" /HighExp="Diami, BMM, GM 15, GM 25, GM 120, GM 60, GM 10, G180, GM 45, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S112" upshifts 321448 /Source="Nicolas_upshifts" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(321516..321534) /Source="Nicolas_upshift_promotors" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 321522..321529 /Source="Nicolas_upshift_promotors" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(321532) /Source="Nicolas_upshifts" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 321544..321563 /Source="Nicolas_upshift_promotors" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(321550..321555) /Source="Nicolas_upshift_promotors" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 321556 /Source="Nicolas_upshifts" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="upshifts" CDS 321592..322152 /gene="aroK" /locus_tag="BSU_03150" /old_locus_tag="BSU03150" /EC_number="2.7.1.71" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 170268, 7612934, 27339308; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="shikimate kinase" /protein_id="NP_388197.2" /db_xref="EnsemblGenomes-Gn:BSU03150" /db_xref="EnsemblGenomes-Tr:CAB12109" /db_xref="GOA:P37944" /db_xref="InterPro:IPR000623" /db_xref="InterPro:IPR023000" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031322" /db_xref="SubtiList:BG10457" /db_xref="UniProtKB/Swiss-Prot:P37944" /translation="MNAKRAIPVRERNIVLIGFMGVGKTTIGQLVAKKLYRDFIDIDQ QIEKDFNMSIPEIFEKKGEDFFRKTEKEYILDICHHKRFKIVSLGGGSFKQEEIRNCC LENCLVLHLDLSWENWKQRADLLIESRPVLHNRSMDEMEQLFNERKVIYDKHNSKVAT DNLSPEEVADYIVETLKIGWDLYQPM*" /label="aroK CDS" gene 321592..322152 /gene="aroK" /locus_tag="BSU_03150" /old_locus_tag="BSU03150" /label="aroK gene" downshifts 322129 /Source="Nicolas_upshifts" /id="D139" /incds=0 /nref=21 /ntot=239 /MaxReadThrough="2.07607" /MaxDrop="4.67156" /score="44.9099474" /energy="-13.1" /TU="NA" /idTUdmin="U232" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(322180..322941) /gene="ycgJ" /locus_tag="BSU_03160" /old_locus_tag="BSU03160" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 28898812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xenotiotic metabolite methyltransferase" /protein_id="NP_388198.2" /db_xref="EnsemblGenomes-Gn:BSU03160" /db_xref="EnsemblGenomes-Tr:CAB12110" /db_xref="GOA:O31474" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="PDB:1XXL" /db_xref="PDB:2GLU" /db_xref="SubtiList:BG12008" /db_xref="UniProtKB/Swiss-Prot:O31474" /translation="MTNETPFSKNAEMYRDEKVFAEGEDLGLMIKTAECRAEHRVLDI GAGAGHTALAFSPYVQECIGVDATKEMVEVASSFAQEKGVENVRFQQGTAESLPFPDD SFDIITCRYAAHHFSDVRKAVREVARVLKQDGRFLLVDHYAPEDPVLDEFVNHLNRLR DPSHVRESSLSEWQAMFSANQLAYQDIQKWNLPIQYDSWIKRGGTPADREKQIITHLN HASDEARDTFCITLNQNGQPISFCLKAILIQGIKR*" /label="ycgJ CDS" gene complement(322180..322941) /gene="ycgJ" /locus_tag="BSU_03160" /old_locus_tag="BSU03160" /label="ycgJ gene" downshifts complement(322204) /Source="Nicolas_upshifts" /id="D140" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="0.31391" /MaxDrop="3.85249" /score="18.9843263" /energy="-13.1" /TU="NA" /idTUdmin="U235" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(322973..322992) /Source="Nicolas_upshift_promotors" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 322974..322981 /Source="Nicolas_upshift_promotors" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(322979) /Source="Nicolas_upshifts" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 322996..323015 /Source="Nicolas_upshift_promotors" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(323007..323012) /Source="Nicolas_upshift_promotors" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 323008 /Source="Nicolas_upshifts" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="upshifts" CDS 323059..324033 /gene="ycgK" /locus_tag="BSU_03170" /old_locus_tag="BSU03170" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_388199.2" /db_xref="EnsemblGenomes-Gn:BSU03170" /db_xref="EnsemblGenomes-Tr:CAB12111" /db_xref="GOA:P94387" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12009" /db_xref="UniProtKB/Swiss-Prot:P94387" /translation="MDIKVMEYAAEIARRQSFTKAAEHLHIAQPSLSQQIKKLEAELG LTLFHRSHGSVTLTPHGRRFIEKAEDIIRSRDDLLREMQERSQGIGHKLSIGIPAVTG RYLFPPLLKQFLARYPHVEVQLVEKDPVSLEKMTAKGEVDLSVLSLPIEDERLSITPL LTEPVVLAVPKEKQRWMPPELVALIEKALEEDEGRQPCVPIDMVRNVPFILLKEGFGF RRTVLDLCAESGFKPNAAFKTSHIETAQSLVANGLGVTMAPNMVRRDKDPGVIYLSIQ SAPSRTLVFVFLKNRYVSLTAQAFMELSRESLKQTFDEGCLGNKDENI*" /label="ycgK CDS" gene 323059..324033 /gene="ycgK" /locus_tag="BSU_03170" /old_locus_tag="BSU03170" /label="ycgK gene" S_feature 324034..324104 /Source="Nicolas_S_feature" /locus_tag="new_342467_342537" /HighExp="Diami, dia5, dia15, S1, dia0, C90, LBGexp, Heat, Lbexp, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S113" CDS 324105..325061 /gene="cah" /locus_tag="BSU_03180" /old_locus_tag="BSU03180" /EC_number="3.1.1.41" /EC_number="3.1.1.72" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12842474, 19837798, 21382014" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12842474, 19837798, 21382014; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous acetyl xylan esterase-cephalosporin C deacetylase" /protein_id="NP_388200.1" /db_xref="EnsemblGenomes-Gn:BSU03180" /db_xref="EnsemblGenomes-Tr:CAB12112" /db_xref="GOA:P94388" /db_xref="InterPro:IPR008391" /db_xref="InterPro:IPR029058" /db_xref="PDB:1L7A" /db_xref="PDB:1ODS" /db_xref="PDB:1ODT" /db_xref="SubtiList:BG11919" /db_xref="UniProtKB/Swiss-Prot:P94388" /translation="MQLFDLPLDQLQTYKPEKTAPKDFSEFWKLSLEELAKVQAEPDL QPVDYPADGVKVYRLTYKSFGNARITGWYAVPDKEGPHPAIVKYHGYNASYDGEIHEM VNWALHGYATFGMLVRGQQSSEDTSISPHGHALGWMTKGILDKDTYYYRGVYLDAVRA LEVISSFDEVDETRIGVTGGSQGGGLTIAAAALSDIPKAAVADYPYLSNFERAIDVAL EQPYLEINSFFRRNGSPETEVQAMKTLSYFDIMNLADRVKVPVLMSIGLIDKVTPPST VFAAYNHLETKKELKVYRYFGHEYIPAFQTEKLAFFKQHLKG*" /label="cah CDS" gene 324105..325061 /gene="cah" /locus_tag="BSU_03180" /old_locus_tag="BSU03180" /label="cah gene" promotor_-35 324520..324526 /Source="Nicolas_upshift_promotors" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 324541..324552 /Source="Nicolas_upshift_promotors" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 324548 /Source="Nicolas_upshifts" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="upshifts" S_feature 325062..325140 /Source="Nicolas_S_feature" /locus_tag="new_343495_343573" /HighExp="dia5, dia15, Diami, dia0, B36, S1, MG 10, BT, B60, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S114" promotor_-35 325115..325120 /Source="Nicolas_upshift_promotors" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 325137..325155 /Source="Nicolas_upshift_promotors" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 325142 /Source="Nicolas_upshifts" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="upshifts" CDS 325145..325927 /gene="ycgL" /locus_tag="BSU_03190" /old_locus_tag="BSU03190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388201.1" /db_xref="EnsemblGenomes-Gn:BSU03190" /db_xref="EnsemblGenomes-Tr:CAB12113" /db_xref="InterPro:IPR018775" /db_xref="SubtiList:BG12010" /db_xref="UniProtKB/Swiss-Prot:P94389" /translation="MKQRIIDELKRIEQSYGVKIVYAVESGSRAWGFPSQDSDYDVRF IYVPKKEWYFSIEQERDVIEEPIHDLLDISGWELRKTLRLFKKSNPPLLEWLSSDIVY YEAFTTAEQLRKLRTEAFKPEASVYHYINMARRNVKDYLQGQEVKIKKYFYVLRPILA CQWIEKHGTIPPMDFTVLMNELVAEPELKAEMETLLERKRRGEELDLEARIDVIHQFI ETEIERIMEAAKELKAEKKDMTSELNRLLLNTVEEVWKDGGS*" /label="ycgL CDS" gene 325145..325927 /gene="ycgL" /locus_tag="BSU_03190" /old_locus_tag="BSU03190" /label="ycgL gene" downshifts 325892 /Source="Nicolas_upshifts" /id="D141" /incds=0 /nref=11 /ntot=63 /MaxReadThrough="3.94077" /MaxDrop="4.37398" /score="0.421649027" /energy="-5.9" /TU="U238" /idTUdmin="U236" /TUdmin=2 /isTUend="TRUE" /label="downshifts" S_feature 325937..326064 /Source="Nicolas_S_feature" /locus_tag="new_344370_344497" /HighExp="S5, S6, S8, S4, S7, B36, B60, BT, S3, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S115" promotor_-35 326041..326045 /Source="Nicolas_upshift_promotors" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 326060..326079 /Source="Nicolas_upshift_promotors" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 326066 /Source="Nicolas_upshifts" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="upshifts" CDS 326118..327029 /gene="putB" /locus_tag="BSU_03200" /old_locus_tag="BSU03200" /EC_number="1.5.5.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17536821, 2118500, 21840319, 22139509, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17536821, 2118500, 21840319, 22139509, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="proline oxidase" /protein_id="NP_388202.1" /db_xref="EnsemblGenomes-Gn:BSU03200" /db_xref="EnsemblGenomes-Tr:CAB12114" /db_xref="GOA:P94390" /db_xref="InterPro:IPR002872" /db_xref="InterPro:IPR008219" /db_xref="InterPro:IPR015659" /db_xref="InterPro:IPR029041" /db_xref="SubtiList:BG12011" /db_xref="UniProtKB/Swiss-Prot:P94390" /translation="MITRDFFLFLSKSGFLNKMARNWGSRVAAGKIIGGNDFNSSIPT IRQLNSQGLSVTVDHLGEFVNSAEVARERTEECIQTIATIADQELNSHVSLKMTSLGL DIDMDLVYENMTKILQTAEKHKIMVTIDMEDEVRCQKTLDIFKDFRKKYEHVSTVLQA YLYRTEKDIDDLDSLNPFLRLVKGAYKESEKVAFPEKSDVDENYKKIIRKQLLNGHYT AIATHDDKMIDFTKQLAKEHGIANDKFEFQMLYGMRSQTQLSLVKEGYNMRVYLPYGE DWYGYFMRRLAERPSNIAFAFKGMTKK*" /label="putB CDS" gene 326118..327029 /gene="putB" /locus_tag="BSU_03200" /old_locus_tag="BSU03200" /label="putB gene" CDS 327046..328593 /gene="putC" /locus_tag="BSU_03210" /old_locus_tag="BSU03210" /EC_number="1.2.1.88" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 17183215, 21840319, 22139509, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 17183215, 21840319, 22139509, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-pyrroline-5-carboxylate dehydrogenase" /protein_id="NP_388203.2" /db_xref="EnsemblGenomes-Gn:BSU03210" /db_xref="EnsemblGenomes-Tr:CAB12115" /db_xref="GOA:P94391" /db_xref="InterPro:IPR005932" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12012" /db_xref="UniProtKB/Swiss-Prot:P94391" /translation="MTTPYKHEPFTNFQDQNNVEAFKKALATVSEYLGKDYPLVINGE RVETEAKIVSINPADKEEVVGRVSKASQEHAEQAIQAAAKAFEEWRYTSPEERAAVLF RAAAKVRRRKHEFSALLVKEAGKPWNEADADTAEAIDFMEYYARQMIELAKGKPVNSR EGEKNQYVYTPTGVTVVIPPWNFLFAIMAGTTVAPIVTGNTVVLKPASATPVIAAKFV EVLEESGLPKGVVNFVPGSGAEVGDYLVDHPKTSLITFTGSREVGTRIFERAAKVQPG QQHLKRVIAEMGGKDTVVVDEDADIELAAQSIFTSAFGFAGQKCSAGSRAVVHEKVYD QVLERVIEITESKVTAKPDSADVYMGPVIDQGSYDKIMSYIEIGKQEGRLVSGGTGDD SKGYFIKPTIFADLDPKARLMQEEIFGPVVAFCKVSDFDEALEVANNTEYGLTGAVIT NNRKHIERAKQEFHVGNLYFNRNCTGAIVGYHPFGGFKMSGTDSKAGGPDYLALHMQA KTISEMF*" /label="putC CDS" gene 327046..328593 /gene="putC" /locus_tag="BSU_03210" /old_locus_tag="BSU03210" /label="putC gene" promotor_-35 328017..328023 /Source="Nicolas_upshift_promotors" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 328037..328056 /Source="Nicolas_upshift_promotors" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 328045 /Source="Nicolas_upshifts" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 328128..328134 /Source="Nicolas_upshift_promotors" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 328147..328166 /Source="Nicolas_upshift_promotors" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 328156 /Source="Nicolas_upshifts" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="upshifts" misc_feature 328592..328596 /Source="Nicolas_upshift_promotors" /id="U242" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.315684315684316" /psig="0.248751248751249" /xcortree=3009 /SigmaFactorBS="cgggccggattacttggctctgcatatgcaagcaaaaacaat cagtgaaatgttctAAGCGggactaaatgggcatcctccctgcgggggtgtccatttc a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 328594..328716 /Source="Nicolas_S_feature" /locus_tag="new_347027_347149" /HighExp="S1, T2.0H, T2.30H, Lbstat, aero, HiOs, BC, Sw, LPh, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52312199999999998" /TUshortSig="Sig-, SigA, SigA, SigA, SigEF" /TUshortPSig="0.249, 1, 0.994, 0.922, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S116" upshifts 328596 /Source="Nicolas_upshifts" /id="U242" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.315684315684316" /psig="0.248751248751249" /xcortree=3009 /SigmaFactorBS="cgggccggattacttggctctgcatatgcaagcaaaaacaat cagtgaaatgttctAAGCGggactaaatgggcatcctccctgcgggggtgtccatttc a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="upshifts" CDS 328717..330138 /gene="putP" /locus_tag="BSU_03220" /old_locus_tag="BSU03220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11902719, 14976255, 15849754, 16850406, 21840319, 22139509, 24142252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902719, 14976255, 15849754, 16850406, 21840319, 22139509, 24142252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proline permease" /protein_id="NP_388204.2" /db_xref="EnsemblGenomes-Gn:BSU03220" /db_xref="EnsemblGenomes-Tr:CAB12116" /db_xref="GOA:P94392" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR011851" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG12013" /db_xref="UniProtKB/Swiss-Prot:P94392" /translation="MLLIGYFAYKRTSNLTDYMLGGRSLGPAVTALSAGAADMSGWLL MGLPGAMFSTGLSGAWIVIGLCLGAWANWLYVAPRLRTYTEKAGNSITIPGFLENRFG DQTKLLRLFSGIVILVFFTFYVSSGMVSGGVLFNSILGMDYHTGLWIVTGVVVAYTLF GGFLAVSWTDFVQGIIMFAALILVPIVTFFHTGGAGDTVAEIRSVDPDMFNIFKGTSV LGIISLFAWGLGYFGQPHIIVRFMAITSVKEIKRARRIGMGWMILSAVGAVLTGLGGI AYYHQRGMTLKDPETIFIQLGNILFHPIITGFLISAILAAIMSTISSQLLVTSSSLVE DLYKSMFRRSASDKELVFLGRLAVLAVSIVALVLAWEKNNTILGLVSYAWAGFGASFG PVVLLSLFWKRMTKWGALAGMIVGAATVIIWANAGLSDFLYEMIPGFAASLLSVFFVS ILTQAPSQAVTDQFNDYQDTMSQ*" /label="putP CDS" gene 328717..330138 /gene="putP" /locus_tag="BSU_03220" /old_locus_tag="BSU03220" /label="putP gene" S_feature complement(329237..331092) /Source="Nicolas_S_feature" /locus_tag="new_347670_349525_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, T3.30H, C30, T4.0H, Lbstat" /AntisenseName="ycgP" /AntisenseCor="0.143781082577395" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.679" /TUlongSig="NA" /TUlongPSig="NA" /label="S117" downshifts 330118 /Source="Nicolas_upshifts" /id="D142" /incds=0 /nref=21 /ntot=160 /MaxReadThrough="5.09597" /MaxDrop="4.17771" /score="5.89792272" /energy="-15.9" /TU="U239,U240,U242" /idTUdmin="U238" /TUdmin=4 /isTUend="TRUE" /label="downshifts" S_feature 330163..330259 /Source="Nicolas_S_feature" /locus_tag="new_348596_348692" /HighExp="S1, LPh, T2.0H, HPh, aero, Lbstat, LoTm, T2.30H, Cold, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.249, 0.994, 0.922" /TUlongSig="NA" /TUlongPSig="NA" /label="S118" promotor_-35 330230..330237 /Source="Nicolas_upshift_promotors" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 330252..330271 /Source="Nicolas_upshift_promotors" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 330261 /Source="Nicolas_upshifts" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="upshifts" CDS 330291..331526 /gene="putR" /locus_tag="BSU_03230" /old_locus_tag="BSU03230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:21840319, 21964733, 22139509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21840319, 21964733, 22139509; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of proline degradationoperon" /protein_id="NP_388205.2" /db_xref="EnsemblGenomes-Gn:BSU03230" /db_xref="EnsemblGenomes-Tr:CAB12117" /db_xref="GOA:P94393" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG12014" /db_xref="UniProtKB/Swiss-Prot:P94393" /translation="MEELLERVFSFSDVDKLIDFISYELQKPVILESADFFLLAYNSY YINHFDSANQQTIFSKKCPVQIFERFLKDGIIEKLKTEPEPFRVNKIESIGLNQRVVV SAKHKGEVMGYIWIQELDQNLTDEELDFLYETSFHVGKIIYKTNKLKQEKEEKAEDLI KRAIYQQFTSEKELRREAERINTVLPSMFSVVILHAANGDGEAVEDLKENIRSYLNLR DKVSHVLTIESNIVIVVASFSQKSSVSSAASEFINKLLTHFHFQKIPTPIYIGIGNEY NHLLKLGKSYTEALEVIKAAEITGNQENIPYEYAKLGIYRYLESIEQKNEFLEYENKD LALLKAKDEESSTELLKTLEIYLLNNCKTKPAAEQLFIHQNTLNYRIKQITEMTSIDL SDFRTRCQLYLDLMLMKKK*" /label="putR CDS" gene 330291..331526 /gene="putR" /locus_tag="BSU_03230" /old_locus_tag="BSU03230" /label="putR gene" promotor_-10 complement(331085..331103) /Source="Nicolas_upshift_promotors" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(331102) /Source="Nicolas_upshifts" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(331117..331124) /Source="Nicolas_upshift_promotors" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(331510) /Source="Nicolas_upshifts" /id="D143" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="0.0291099999999993" /MaxDrop="3.08474" /score="-9.94728494" /energy="-16.9" /TU="NA" /idTUdmin="U245" /TUdmin=66 /isTUend="FALSE" /label="downshifts" CDS complement(331563..332420) /gene="ycgQ" /locus_tag="BSU_03240" /old_locus_tag="BSU03240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388206.1" /db_xref="EnsemblGenomes-Gn:BSU03240" /db_xref="EnsemblGenomes-Tr:CAB12118" /db_xref="GOA:P94394" /db_xref="InterPro:IPR015402" /db_xref="SubtiList:BG12015" /db_xref="UniProtKB/Swiss-Prot:P94394" /translation="MFRLLVLMGFTFFFYHLHASGNLTKYINMKYAYLSFIAIFLLAI LTAVQAYLFIKSPEKSGHHHDHDCGCGHDHEHDHEQNKPFYQRYLIYVVFLFPLVSGI FFPIATLDSSIVKTKGFSFKAMESGDHYSQTQYLRPDASLYYAQDSYDKQMKQLFNKY SSKKEISLTDDDFLKGMETIYNYPGEFLGRTIEFHGFAYKGNAINKNQLFVLRFGIIH CIADSGVYGMLVEFPKDMDIKDDEWIHIKGTLASEYYQPFKSTLPVVKVTDWNTIKKP DDPYVYRGF*" /label="ycgQ CDS" gene complement(331563..332420) /gene="ycgQ" /locus_tag="BSU_03240" /old_locus_tag="BSU03240" /label="ycgQ gene" downshifts complement(331576) /Source="Nicolas_upshifts" /id="D144" /incds=0 /nref=48 /ntot=167 /MaxReadThrough="1.97725" /MaxDrop="4.53007" /score="-9.94728494" /energy="-16.9" /TU="NA" /idTUdmin="U245" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(332425..333309) /gene="ycgR" /locus_tag="BSU_03250" /old_locus_tag="BSU03250" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388207.1" /db_xref="EnsemblGenomes-Gn:BSU03250" /db_xref="EnsemblGenomes-Tr:CAB12119" /db_xref="GOA:P94395" /db_xref="InterPro:IPR005524" /db_xref="SubtiList:BG12016" /db_xref="UniProtKB/Swiss-Prot:P94395" /translation="MTAQSSFLQLNSIFISILIEAIPFILIGVILSGIIQMFVSEEMI ARIMPKNRFLAVLFGALAGVLFPACECGIIPITRRLLLKGVPLHAGVAFMLTAPIINP IVLFSTYIAFGNRWSVVFYRGGLALAVSLIIGVILSYQFKDNQLLKPDEPGHHHHHHG TLLQKLGGTLRHAIDEFFSVGKYLIIGAFIAAAMQTYVKTSTLLAIGQNDVSSSLVMM GLAFVLSLCSEVDAFIASSFSSTFSLGSLIAFLVFGAMVDIKNLLMMLAAFKKRFVFL LITYIVVIVLAGSLLVKG*" /label="ycgR CDS" gene complement(332425..333309) /gene="ycgR" /locus_tag="BSU_03250" /old_locus_tag="BSU03250" /label="ycgR gene" upshifts complement(333361) /Source="Nicolas_upshifts" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(333366..333379) /Source="Nicolas_upshift_promotors" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(333394..333402) /Source="Nicolas_upshift_promotors" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(333409..334263) /gene="ycgS" /locus_tag="BSU_03260" /old_locus_tag="BSU03260" /EC_number="3.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aromatic hydrocarbon hydrolase" /protein_id="NP_388208.1" /db_xref="EnsemblGenomes-Gn:BSU03260" /db_xref="EnsemblGenomes-Tr:CAB12120" /db_xref="GOA:P94396" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12017" /db_xref="UniProtKB/Swiss-Prot:P94396" /translation="MKRRVETITFDGGTLEYSVTGKGTPILVMHGGHSNCYEEFGYTA LIEQGYSIITPSRPGYGRTSKEIGKSLANACRFYVKLLDHLQIESVHVIAISAGGPSG ICFASHYPERVNTLTLQSAVTKEWLTPKDTEYKLGEILFRPPVEKWIWKLISSLNNAF PRLMFRAMSPQFSTLPFQRIKSLMNEKDIEAFRKMNSRQRSGEGFLIDLSQTAAVSLK DLQAIICPVLIMQSVYDGLVDLSHAHHAKEHIRGAVLCLLHSWGHLIWLGKEAAETGS ILLGFLES*" /label="ycgS CDS" gene complement(333409..334263) /gene="ycgS" /locus_tag="BSU_03260" /old_locus_tag="BSU03260" /label="ycgS gene" promotor_-10 complement(334282..334301) /Source="Nicolas_upshift_promotors" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="promotor_-10" upshifts complement(334302) /Source="Nicolas_upshifts" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="upshifts" promotor_-35 complement(334316..334319) /Source="Nicolas_upshift_promotors" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="promotor_-35" misc_feature 334353..334372 /Source="Nicolas_upshift_promotors" /id="U247" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.993006993006993" /xcortree=2116 /SigmaFactorBS="ttcagcaattgaccacaaggtagaagaaatgaataaacaaag gcccttgaaaTATGATATACTTTGTATTGAtattcattctcaattaaaactttgatat a" /listShort="S119, ycgT, S120" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(334353..334371) /Source="Nicolas_upshift_promotors" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 334360..334424 /Source="Nicolas_S_feature" /locus_tag="new_352793_352857" /HighExp="B60, Lbexp, LBGexp, dia0, B36, HiOs, GM 15, GM 10, Salt, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S119" upshifts 334361 /Source="Nicolas_upshifts" /id="U247" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.993006993006993" /xcortree=2116 /SigmaFactorBS="ttcagcaattgaccacaaggtagaagaaatgaataaacaaag gcccttgaaaTATGATATACTTTGTATTGAtattcattctcaattaaaactttgatat a" /listShort="S119, ycgT, S120" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(334370) /Source="Nicolas_upshifts" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(334387..334392) /Source="Nicolas_upshift_promotors" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 334425..335435 /gene="ffoR" /locus_tag="BSU_03270" /old_locus_tag="BSU03270" /EC_number="1.18.1.-" /EC_number="1.8.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16672620, 25826316" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16672620, 25826316; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Fur-regulated NADPH:ferredoxin oxidoreductase" /protein_id="NP_388209.1" /db_xref="EnsemblGenomes-Gn:BSU03270" /db_xref="EnsemblGenomes-Tr:CAB12121" /db_xref="GOA:O31475" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR022890" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12018" /db_xref="UniProtKB/Swiss-Prot:O31475" /translation="MAENQEVYDVTIIGGGPIGLFTAFYCGMRELKTKVIEFLPKLGG KVSLFFPEKIIRDIGGIPGIAGKQLIEQLKEQAATFDPDIVLNQRVTGFERLDDGTIV LTGSEGKKHYTRTVILACGMGTLEVNEFDSEDAARYAGKNLHYGVEKLDAFKGKRVVI SGGGDTAVDWANELEPIAASVTVVHRREEFGGMESSVTKMKQSSVRVLTPYRLEQLNG DEEGIKSVTVCHTESGQRKDIEIDELIINHGFKIDLGPMMEWGLEIEEGRVKADRHMR TNLPGVFVAGDAAFYESKLRLIAGGFTEGPTAVNSAKAYLDPKAENMAMYSTHHKKLV HK*" /label="ffoR CDS" gene 334425..335435 /gene="ffoR" /locus_tag="BSU_03270" /old_locus_tag="BSU03270" /label="ffoR gene" S_feature 335436..337883 /Source="Nicolas_S_feature" /locus_tag="new_353869_356316" /HighExp="B60, Lbexp, GM 10, GM 25, HiOs, GM 15, dia0, GM 45, LBGexp, H2O2" /AntisenseName="nasF" /AntisenseCor="-0.30348565853404702" /AntisenseRegPval="-6.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S120" CDS complement(335467..336918) /gene="nasF" /locus_tag="BSU_03280" /old_locus_tag="BSU03280" /EC_number="2.1.1.107" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9765565, 10217486, 15028686" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9765565, 10217486, 15028686; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrin-III C-methyltransferase" /protein_id="NP_388210.1" /db_xref="EnsemblGenomes-Gn:BSU03280" /db_xref="EnsemblGenomes-Tr:CAB12122" /db_xref="GOA:P42437" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR003043" /db_xref="InterPro:IPR006366" /db_xref="InterPro:IPR012409" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR035996" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG11098" /db_xref="UniProtKB/Swiss-Prot:P42437" /translation="MIMKNGIVYFVGAGPGDPGLLTIKGKQALKEADVILYDRLANPK LLEFASPDCQFIYCGKLPNRHFMKQKEINALLVEKALNGLTVVRLKGGDPSVFGRVGE EADALHEHGIRYEMVPGITSGIAAPLYAGIPVTHRDFASSFAMITAHDKSLKGTPNLD WEGLARSVQTLVFYMGVKNLSYICQQLISYGKSPSVPVIVIQWGTWGRQRSVKGTLEN IQQKVQEHQITNPAIIVIGDIVNFQTHSWFESKPLIGRHLMVVTHGEDEDPLADKLRD SGADLIEWPKWRTENMPVNEEILRKIGTFEDVFFTSRRAVCEFFRALASQKIDIRQLT AKLSAASEQAKTELEKRGFLVTAIQPDSEKRLVVGSRHAVENMQKHESCSFYITHENV IDDRFTHMIQRTISESPLHMVICPNKLSVQQLINGGEQIGILPEPSASRPPIVCIGDD SAAGIYGFTAVQEQDELLAFIHNQHAEKKLLHT*" /label="nasF CDS" gene complement(335467..336918) /gene="nasF" /locus_tag="BSU_03280" /old_locus_tag="BSU03280" /label="nasF gene" downshifts complement(335471) /Source="Nicolas_upshifts" /id="D145" /incds=0 /nref=131 /ntot=230 /MaxReadThrough="1.40657" /MaxDrop="6.58881" /score="10.9556399" /energy="-11.7" /TU="NA" /idTUdmin="U250" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(336979..337299) /gene="nasE" /locus_tag="BSU_03290" /old_locus_tag="BSU03290" /EC_number="1.7.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10217486, 15028686, 9765565, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217486, 15028686, 9765565, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrite reductase subunit" /protein_id="NP_388211.1" /db_xref="EnsemblGenomes-Gn:BSU03290" /db_xref="EnsemblGenomes-Tr:CAB12123" /db_xref="GOA:P42436" /db_xref="InterPro:IPR012748" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG11097" /db_xref="UniProtKB/Swiss-Prot:P42436" /translation="MVNKDVTKVCIGKIEELPEQLGKTVYIEDKELAVFKLSDGSIRA IENRCPHKGGVLAEGIVSGQYVFCPMHDWKISLEDGIVQEPDHGCVKTYETLIEGEHV YLVY*" /label="nasE CDS" gene complement(336979..337299) /gene="nasE" /locus_tag="BSU_03290" /old_locus_tag="BSU03290" /label="nasE gene" promotor_-35 337150..337155 /Source="Nicolas_upshift_promotors" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 337169..337173 /Source="Nicolas_upshift_promotors" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 337176 /Source="Nicolas_upshifts" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(337208) /Source="Nicolas_upshifts" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(337210..337229) /Source="Nicolas_upshift_promotors" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(337243..337250) /Source="Nicolas_upshift_promotors" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(337331..339748) /gene="nasD" /locus_tag="BSU_03300" /old_locus_tag="BSU03300" /EC_number="1.7.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 9765565, 16428414, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 9765565, 16428414, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrite reductase subunit" /protein_id="NP_388212.1" /db_xref="EnsemblGenomes-Gn:BSU03300" /db_xref="EnsemblGenomes-Tr:CAB12124" /db_xref="GOA:P42435" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR006066" /db_xref="InterPro:IPR006067" /db_xref="InterPro:IPR007419" /db_xref="InterPro:IPR012744" /db_xref="InterPro:IPR017121" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036136" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11096" /db_xref="UniProtKB/Swiss-Prot:P42435" /translation="MGKKQLVLVGNGMAGVRAIEEILSVAKDEFQITIFGAEPHPNYN RILLSKVLQGDTDIKDITLNDWDWYEENNIQLYTNETVIKVDTENKTVITDADRIQPY DELILATGSVPFILPIPGADKKGVTAFRDIKDTDTMLAASKQYKKAAVIGGGLLGLEA ARGLLNLGMDVSVIHLAPFLMERQLDATAGRLLQNELEKQGMTFLLEKQTEEIVGDDR VEGLRFKDGTSIEADLVVMAVGIRPNTTLGAESGIPVNRGIIVNDYMQTEIPHIYAVG ECAEHRGIAYGLVAPLYEQAKVLAKHMCGIETKPYEGSVLSTQLKVSGVEVFSAGDFN ESEEKKAIKVFDEQDGIYKKIVLRGNQIVGAVLFGDSSEGNRLFSMIQKEADISETSK ISILQPLSQEAGTSITAAMSDDEIICGCNGVSKGAIIQAIQEKGCSSTDEIKACTGAS RSCGGCKPLVEEILQHTLGSDFDASAQKEAICGCTTLSRDEVVEEIKAKGLSHTREVM NVLGWKTPEGCSKCRPALNYYLGMINPTKYEDDRTSRFVNERMHANIQKDGTYSVVPR MYGGVTNSTDLRKIADVVDKYEIPLVKMTGGQRIDLIGVKKEDLPKVWEDLDMPSGYA YGKTLRTVKTCVGEQFCRFGTQDSMALGIALEKKFEGLNTPHKVKMAVSACPRNCAES GIKDLGVVGIDGGWELYVGGNGGTHLRAGDLLMKVKTNEEVLEYAGAYLQYYRETANY LERTSAWLERVGLSHVQSVLNDPEKRQELNGRMNETLSVHKDPWKDFLEDKQTSKELF ENVVTTS*" /label="nasD CDS" gene complement(337331..339748) /gene="nasD" /locus_tag="BSU_03300" /old_locus_tag="BSU03300" /label="nasD gene" promotor_-10 complement(339773..339792) /Source="Nicolas_upshift_promotors" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(339787) /Source="Nicolas_upshifts" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(339804..339810) /Source="Nicolas_upshift_promotors" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(339870..342002) /gene="nasC" /locus_tag="BSU_03310" /old_locus_tag="BSU03310" /EC_number="1.7.99.4" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 9765565" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 9765565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrate reductase (catalytic subunit)" /protein_id="NP_388213.2" /db_xref="EnsemblGenomes-Gn:BSU03310" /db_xref="EnsemblGenomes-Tr:CAB12125" /db_xref="GOA:P42434" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR027467" /db_xref="SubtiList:BG11095" /db_xref="UniProtKB/Swiss-Prot:P42434" /translation="MTERLLRYFRDKQQDVQSEKTYDTQCPFCSMQCKMQLVEQTIVT RKKYTAIGIDNPTTQGRLCIKGMNAHQHALNSSRITRPLLKKNGEFMPVSWEEALNHI KDQVTMIQTEHGHDAMAVYGSASITNEEAYLLGKFARVGLQTKYIDYNGRLCMSAAAT AANQTFGADRGLTNPLSDIPHTRVIILAGTNIAECQPTIMPYFEKAKENGAYFIAIDP RETATTKIADLHLKIKPGTDAALANGLVKIIIDEQLINEDFIQSRTNGFEELKQHTDS LDLNDIAEQTSVSLVDIRKAAVKFAKETSGMLFTARGIEQQTDGTAAVKGFLNMVLIT GKIGKPYSGYGAITGQGNGQGAREHGQKADQLPGYRSIENEEHRAHIAKVWGIHQDEL PRKGVSAYEMMEKINDGDIKGLFLMCSNPAVSSPNANLVKKALRRLTFFVAIDLFISE TAKYADVILPASSYLEDEGTMTNVEGRVTLREASRPCPGEAKHDWQIICDLASALGKG RYFSYTSAEDIFNELREASRGGIADYSGISYGRLRREGGIHWPCPESDHPGTGRLFTE SFAHPDQKAALSVIPNEPPVPKEKPTADYPLYLTTGRVMSHYLTGVQTRKSAALAARH FESFMEIHPQTAATYNIEDRVLVKIESPRGSITVRSKLSEQIRKDTVFVPIHWADAQN VNDLIGEALDPACKMPGFKVCAVRIIPI*" /label="nasC CDS" gene complement(339870..342002) /gene="nasC" /locus_tag="BSU_03310" /old_locus_tag="BSU03310" /label="nasC gene" CDS complement(342009..344324) /gene="nasB" /locus_tag="BSU_03320" /old_locus_tag="BSU03320" /EC_number="1.7.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7836289, 8799114, 9765565, 10940050, 10972836, 15028686, 24122235" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7836289, 8799114, 9765565, 10940050, 10972836, 15028686, 24122235; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrate reductase (electron transfer subunit NasB)" /protein_id="NP_388214.2" /db_xref="EnsemblGenomes-Gn:BSU03320" /db_xref="EnsemblGenomes-Tr:CAB12126" /db_xref="GOA:P42433" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR007419" /db_xref="InterPro:IPR012744" /db_xref="InterPro:IPR017121" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036136" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11094" /db_xref="UniProtKB/Swiss-Prot:P42433" /translation="MKKQRLVLAGNGMAGIRCIEEVLKLNRHMFEIVIFGSEPHPNYN RILLSSVLQGEASLDDITLNSKDWYDKHGITLYTGETVIQIDTDQQQVITDRKRTLSY DKLIVATGSSPHILPIPGADKKGVYGFRTIEDCQALMNMAQHFQKAAVIGAGLLGLEA AVGLQHLGMDVSVIHHSAGIMQKQLDQTAARLLQTELEQKGLTFLLEKDTVSISGATK ADRIHFKDGSSLKADLIVMAAGVKPNIELAVSAGIKVNRGIIVNDFMQTSEPNIYAVG ECAEHNGTVYGLVAPLYEQGKALASHICGVPCEEYQGSAPSAALKIAGIDVWSAGKIQ EDERTTSIKIYDEQAGVYKKALFVDDKLAGVILFGDTRDKQRLLDSLLKQRDISIAKK QIIEPETSGPLFESMPSSETICQCNTVTKGAIEDAVHTNSLTTVEEVKHCTKATGSCG GCKPLVEDLLRYMTNSEYTKPASTPSFCSCTDFTEDDIIAELQRRPFTNPAEVMNQLD WKTKNGCSTCVPAIQYYLEMLYPGFVQPEPATEETCILIPQMYGGRTNAEQLRTIANI IEAYSIPDVSITHGQRLKLSGIKPADLPNMKKDLKMPVYTNEHRHALQSIKACTCGQN RSIQQLAAQIERQLEMLPLPAPISISLSCETDCTEAALQDVGAIRTQAGWDIHIGGVR GTHARSGALFCVTENEDSTAGMIKGLIQYYRETAHYLEGVHQWIDRLGIVHIREVLFE EDLRAQLLESLQTDLSLIQNPTVETGAYKKG*" /label="nasB CDS" gene complement(342009..344324) /gene="nasB" /locus_tag="BSU_03320" /old_locus_tag="BSU03320" /label="nasB gene" promotor_no_box complement(344343..344443) /Source="Nicolas_upshift_promotors" /id="U252" /multdbtbs="SigA" /comp="M21" /sig="Sig-" /pcomp="0.241758241758242" /psig="0.410589410589411" /xcortree=313 /SigmaFactorBS="ttattttctggaaaagacatgtgtaagtttttgtgacacgtt taatgcgttaacaatgcattgtgacataatttttaataggagaaaacttacgagcttc g" /listShort="nasB, nasC, nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(344383) /Source="Nicolas_upshifts" /id="U252" /multdbtbs="SigA" /comp="M21" /sig="Sig-" /pcomp="0.241758241758242" /psig="0.410589410589411" /xcortree=313 /SigmaFactorBS="ttattttctggaaaagacatgtgtaagtttttgtgacacgtt taatgcgttaacaatgcattgtgacataatttttaataggagaaaacttacgagcttc g" /listShort="nasB, nasC, nasD, nasE, nasF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 344426..344433 /Source="Nicolas_upshift_promotors" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 344447..344466 /Source="Nicolas_upshift_promotors" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 344459 /Source="Nicolas_upshifts" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="upshifts" CDS 344504..345709 /gene="nasA" /locus_tag="BSU_03330" /old_locus_tag="BSU03330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7868621, 12823818, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative nitrate transporter" /protein_id="NP_388215.2" /db_xref="EnsemblGenomes-Gn:BSU03330" /db_xref="EnsemblGenomes-Tr:CAB12127" /db_xref="GOA:P42432" /db_xref="InterPro:IPR004737" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11093" /db_xref="UniProtKB/Swiss-Prot:P42432" /translation="MKLSELKTSGHPLTLLCSFLYFDVSFMIWVMLGALGVYISQDFG LSPFEKGLVVAVPILSGSVFRIILGILTDRIGPKKTAVIGMLVTMIPLLWGTFGGRSL TELYAIGILLGVAGASFAVALPMASRWYPPHLQGLAMGIAGAGNSGTLFATLFGPRLA EQFGWHIVMGIALIPLLIVFILFVSMAKDSPAQPSPQPLKSYLHVFGQKETWFFCLLY SVTFGGFVGLSSFLSIFFVDQYQLSKIHAGDFVTLCVAAGSFFRPVGGLISDRVGGTK VLSVLFVIVALCMAGVSSLPSLSMVIVLLFVGMMGLGMGNGAVFQLVPQRFRKEIGMV TGIVGAAGGIGGFFLPNILGSLKQMTGTYAIGFITFSCIALLAFALVLAAGYYWRKSW SAESSPADV*" /label="nasA CDS" gene 344504..345709 /gene="nasA" /locus_tag="BSU_03330" /old_locus_tag="BSU03330" /label="nasA gene" downshifts 345694 /Source="Nicolas_upshifts" /id="D146" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.02479" /MaxDrop="3.6823" /score="39.2612286" /energy="-11.9" /TU="NA" /idTUdmin="U253" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 345753..345759 /Source="Nicolas_upshift_promotors" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="promotor_-35" promotor_-10 345774..345793 /Source="Nicolas_upshift_promotors" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="promotor_-10" upshifts 345782 /Source="Nicolas_upshifts" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="upshifts" CDS 345826..346740 /gene="folEB" /locus_tag="BSU_03340" /old_locus_tag="BSU03340" /EC_number="3.5.4.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12426338, 17032654, 19767425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12426338, 17032654, 19767425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP cyclohydrolase I" /protein_id="NP_388216.2" /db_xref="EnsemblGenomes-Gn:BSU03340" /db_xref="EnsemblGenomes-Tr:CAB12128" /db_xref="GOA:P94398" /db_xref="InterPro:IPR003801" /db_xref="InterPro:IPR022838" /db_xref="SubtiList:BG12019" /db_xref="UniProtKB/Swiss-Prot:P94398" /translation="MNQHTLLPKKTERLQYFGSVSPIKGEKPVEKEKMKDLQNIRKDY FFDIQHVGVANVSHPVTITSAMMPAEQTTAANFTMTCNLPRNQKGINMSRLTELLQVY HQNGWILSFSSLQQFTKELAENMDTSSATVEVRFPWFFERKSPKLEKAGLMHADIFMS VTYRKDQPFKQRAGISAKVTTLCPCSKEISEYSAHNQRGTVSIWADIHPAASLPSDVK ADLLHAAESNASARLHPVLKRPDEKAVTETAYENPRFVEDLARLIAADLFELEWVSAF EIECRNEESIHLHDAYAKLCFSKEVDKI*" /label="folEB CDS" gene 345826..346740 /gene="folEB" /locus_tag="BSU_03340" /old_locus_tag="BSU03340" /label="folEB gene" CDS 346737..347321 /gene="yciB" /locus_tag="BSU_03350" /old_locus_tag="BSU03350" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12426338, 20013255; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative Zn(2+)-dependent division lipoprotein (schizosome)" /protein_id="NP_388217.2" /db_xref="EnsemblGenomes-Gn:BSU03350" /db_xref="EnsemblGenomes-Tr:CAB12129" /db_xref="GOA:C0SP99" /db_xref="InterPro:IPR005490" /db_xref="SubtiList:BG12020" /db_xref="UniProtKB/Swiss-Prot:C0SP99" /translation="MKLSLFIIAVLMPVILLSACSDHAEEHASINTKKTVENITDVRK TAKTSIDWTKPSGGEYPDIKQKHVWIDVNVKEQKAYIKEGSNTIYTMMISSGLDQTKD DATPKGTFYVEPERGEWFFSEGYQEGAEYWVSWKNHGEFLFHSVPMTKDQKVIKTEAE KLGTKASHGCIRLTIPDAKWVYENIPEHTKVVIS*" /label="yciB CDS" gene 346737..347321 /gene="yciB" /locus_tag="BSU_03350" /old_locus_tag="BSU03350" /label="yciB gene" promotor_-35 347332..347339 /Source="Nicolas_upshift_promotors" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 347353..347372 /Source="Nicolas_upshift_promotors" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 347363 /Source="Nicolas_upshifts" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="upshifts" CDS 347417..347602 /gene="yczL" /locus_tag="BSU_03359" /old_locus_tag="BSU03359" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097674.1" /db_xref="EnsemblGenomes-Gn:BSU03359" /db_xref="EnsemblGenomes-Tr:CAX52544" /db_xref="UniProtKB/Swiss-Prot:C0H3U7" /translation="MKSGKASIKDLAVGKGKDLRWGKGLNAVGVFTDLEIGRQREMSA KSCSTPLYIRRSIQFKS*" /label="yczL CDS" gene 347417..347602 /gene="yczL" /locus_tag="BSU_03359" /old_locus_tag="BSU03359" /label="yczL gene" CDS 347630..348823 /gene="zinU" /locus_tag="BSU_03360" /old_locus_tag="BSU03360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2013568, 9811636, 12426338, 18344368, 19648245, 27060116, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2013568, 9811636, 12426338, 18344368, 19648245, 27060116, 27561249; Product type t: transporter" /codon_start=1 /transl_table=11 /product="zinc metallochaperone with NTPase activity" /protein_id="NP_388218.1" /db_xref="EnsemblGenomes-Gn:BSU03360" /db_xref="EnsemblGenomes-Tr:CAB12130" /db_xref="GOA:P94400" /db_xref="InterPro:IPR003495" /db_xref="InterPro:IPR011629" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036627" /db_xref="SubtiList:BG12021" /db_xref="UniProtKB/Swiss-Prot:P94400" /translation="MKKIPVTVLSGYLGAGKTTLLNSILQNREGLKIAVIVNDMSEVN IDAGLVKQEGGLSRTDEKLVEMSNGCICCTLREDLLIEVEKLAKDGRFDYIVIESTGI SEPIPVAQTFSYIDEEMGIDLTKFCQLDTMVTVVDANRFWHDYQSGESLLDRKEALGE KDEREIADLLIDQIEFCDVLILNKCDLVSEQELEQLENVLRKLQPRARFIRSVKGNVK PQEILHTGLFNFEEASGSAGWIQELTAGHAEHTPETEEYGISSFVYKRRLPFHSTRFY RWLDQMPKNVVRAKGIVWCASHNNLALLMSQAGPSVTIEPVSYWVAALPKLEQEQVKQ QEPEILEEWDPEFGDRLTQLVFIGTDLDEETITKELDQCLLTEYEFDSDWSLFEDPFK WKLNQ*" /label="zinU CDS" gene 347630..348823 /gene="zinU" /locus_tag="BSU_03360" /old_locus_tag="BSU03360" /label="zinU gene" downshifts 348815 /Source="Nicolas_upshifts" /id="D147" /incds=0 /nref=26 /ntot=45 /MaxReadThrough="5.12378" /MaxDrop="5.8275" /score="15.6427627" /energy="-9.2" /TU="U255" /idTUdmin="U255" /TUdmin="-792" /isTUend="FALSE" /label="downshifts" S_feature 348860..350529 /Source="Nicolas_S_feature" /locus_tag="new_367293_368962" /HighExp="Etha, B60, Cold, Heat, B36, C30, BMM, S6, C90, S2" /AntisenseName="yckB" /AntisenseCor="-0.170121935628575" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S121" CDS complement(348872..349552) /gene="yckA" /locus_tag="BSU_03370" /old_locus_tag="BSU03370" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 23038252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="aminoacid ABC transporter (permease subunit)" /protein_id="NP_388219.1" /db_xref="EnsemblGenomes-Gn:BSU03370" /db_xref="EnsemblGenomes-Tr:CAB12131" /db_xref="GOA:P42399" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11177" /db_xref="UniProtKB/Swiss-Prot:P42399" /translation="MINSIQWEYIFNTKLAIESFPYVIKGIGYTLLISFVSMFAGTVI GLFISLARMSKLALLRWPAKLYISFMRGVPILVILFILYFGFPYIGIEFSAVTAALIG FSLNSAAYIAEINRSAISSVEKGQWEAASSLGLSYWQTMRGIILPQSIRIALPPLANV LLDLIKASSLAAMITVPELLQHAKIIGGREFDYMTMYILTALIYWAICSIAAVFQNIL EKKYAHYV*" /label="yckA CDS" gene complement(348872..349552) /gene="yckA" /locus_tag="BSU_03370" /old_locus_tag="BSU03370" /label="yckA gene" downshifts complement(348878) /Source="Nicolas_upshifts" /id="D148" /incds=0 /nref=101 /ntot=231 /MaxReadThrough="0.41655" /MaxDrop="6.18136" /score="40.1548023" /energy="-12.6" /TU="NA" /idTUdmin="U256" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(349562..350425) /gene="yckB" /locus_tag="BSU_03380" /old_locus_tag="BSU03380" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23038252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23038252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="amino acid ABC transporter (binding lipoprotein subunit)" /protein_id="NP_388220.1" /db_xref="EnsemblGenomes-Gn:BSU03380" /db_xref="EnsemblGenomes-Tr:CAB12132" /db_xref="GOA:P42400" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="PDB:2IEE" /db_xref="SubtiList:BG11178" /db_xref="UniProtKB/Swiss-Prot:P42400" /translation="MKSFMHSKAVIFSFTMAFFLILAACSGKNEADSKDTGWEQIKDK GKIVVATSGTLYPTSYHDTDSGSDKLTGYEVEVVREAAKRLGLKVEFKEMGIDGMLTA VNSGQVDAAANDIDVTKDREEKFAFSTPYKYSYGTAIVRKDDLSGIKTLKDLKGKKAA GAATTVYMEVARKYGAKEVIYDNATNEQYLKDVANGRTDVILNDYYLQTLALAAFPDL NITIHPDIKYMPNKQALVMKKSNAALQKKMNEALKEMSKDGSLTKLSKQFFNKADVSK KIDADVQDVDL*" /label="yckB CDS" gene complement(349562..350425) /gene="yckB" /locus_tag="BSU_03380" /old_locus_tag="BSU03380" /label="yckB gene" promotor_-10 complement(350447..350466) /Source="Nicolas_upshift_promotors" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(350459) /Source="Nicolas_upshifts" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(350461..353295) /Source="Nicolas_S_feature" /locus_tag="new_368894_371728_c" /HighExp="GM 150, T-4.40H, G/S, Pyr, S2, C30, T-5.40H, C90, T-3.40H, T0.30H" /AntisenseName="bglC" /AntisenseCor="-0.37749573319969598" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, Sig-" /TUshortPSig="0.248, 0.994, 0.0879" /TUlongSig="SigD" /TUlongPSig=1 /label="S122" promotor_-35 complement(350481..350488) /Source="Nicolas_upshift_promotors" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 350498..350504 /Source="Nicolas_upshift_promotors" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 350519..350537 /Source="Nicolas_upshift_promotors" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 350531..350753 /Source="Nicolas_S_feature" /locus_tag="new_368964_369186" /HighExp="Etha, Salt, B60, Sw, B36, Gly, Heat, S6, Cold, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99896700000000005" /TUshortSig="SigB" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S123" upshifts 350531 /Source="Nicolas_upshifts" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="upshifts" CDS 350587..350784 /locus_tag="BSU_03385" /old_locus_tag="BSU03385" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513942.1" /translation="MSKDECQTYQGNACESEGCSRPVTHLCQYRKKWSRGMKPIFRIN LSLADAPKAYDIFDEKENGNI*" /label="hypothetical protein CDS" gene 350587..350784 /locus_tag="BSU_03385" /old_locus_tag="BSU03385" /label="gene" promotor_-35 350722..350727 /Source="Nicolas_upshift_promotors" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 350743..350761 /Source="Nicolas_upshift_promotors" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 350755 /Source="Nicolas_upshifts" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="upshifts" CDS 350803..351258 /gene="yckC" /locus_tag="BSU_03390" /old_locus_tag="BSU03390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral membrane protein of unknown function" /protein_id="NP_388221.1" /db_xref="EnsemblGenomes-Gn:BSU03390" /db_xref="EnsemblGenomes-Tr:CAB12133" /db_xref="GOA:P42401" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG11179" /db_xref="UniProtKB/Swiss-Prot:P42401" /translation="MNIYKPAGFWIRLGAALLDYIIVSVPLLLIYWLITGKDPNDSMF ISLVVLLYSILLPMFWRGYLIGKRICGIRIVKKDGSQVSLLTMFLRVIVAGLVYCITF GLGLIASLILIAVREDKRTLHDLIAGTYVTYATPGEEELNADEEIRKSE*" /label="yckC CDS" gene 350803..351258 /gene="yckC" /locus_tag="BSU_03390" /old_locus_tag="BSU03390" /label="yckC gene" downshifts 351233 /Source="Nicolas_upshifts" /id="D149" /incds=0 /nref=40 /ntot=193 /MaxReadThrough="1.14817" /MaxDrop="5.48303" /score="23.1539807" /energy="-9.8" /TU="NA" /idTUdmin="U257" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 351281..351287 /Source="Nicolas_upshift_promotors" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 351294 /Source="Nicolas_upshifts" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 351301..351312 /Source="Nicolas_upshift_promotors" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 351340..351672 /gene="yckD" /locus_tag="BSU_03400" /old_locus_tag="BSU03400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388222.1" /db_xref="EnsemblGenomes-Gn:BSU03400" /db_xref="EnsemblGenomes-Tr:CAB12134" /db_xref="InterPro:IPR024485" /db_xref="SubtiList:BG11180" /db_xref="UniProtKB/Swiss-Prot:P42402" /translation="MKRITINIITMFIAAAVISLTGTAEAAEKQQQSPANVTLTDQQK KEIEQLEAEILKKRKDVISKYVQYGILPKERGEHIKNHLDKHFEMMKQNGFVPKHHPH PHKFEKRH*" /label="yckD CDS" gene 351340..351672 /gene="yckD" /locus_tag="BSU_03400" /old_locus_tag="BSU03400" /label="yckD gene" downshifts 351653 /Source="Nicolas_upshifts" /id="D150" /incds=0 /nref=20 /ntot=44 /MaxReadThrough="2.48743" /MaxDrop="4.3022" /score="-1.40416926" /energy="-11.8" /TU="NA" /idTUdmin="U259" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 351758..351765 /Source="Nicolas_upshift_promotors" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 351781..351800 /Source="Nicolas_upshift_promotors" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 351785 /Source="Nicolas_upshifts" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="upshifts" CDS 351826..353259 /gene="bglC" /locus_tag="BSU_03410" /old_locus_tag="BSU03410" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14652714, 15139916, 18069788" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652714, 15139916, 18069788; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-phospho-beta-d-glucosidase" /protein_id="NP_388223.1" /db_xref="EnsemblGenomes-Gn:BSU03410" /db_xref="EnsemblGenomes-Tr:CAB12135" /db_xref="GOA:P42403" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG11181" /db_xref="UniProtKB/Swiss-Prot:P42403" /translation="MIHQHPESFPKHFLWGSASAAYQIEGAWNEDGKGPSVWDVFTKI PGKTFKGTNGEIAVDHYHRFKEDVALMAEMGLKAYRFSVSWPRVFPKGKGEINEAGLA FYDSLIDELLSHHIEPVLTLYHWDLPQALMDEYGGFESRNIIEDFNHYCITLYKRFGD RVKYWVTLNEQNYNFNHGFITAMHPPGVKDRKRFYEANHIAFLANAKAIESFREYVPE GKIGPSFAYSPAYPLSSHPEDILAFENAEEFTNNWWLDMYCWGTYPQIPFRCLEKQGW APTIEAGDMDLLAKGKPDFVGVNYYQTITYERNPLDGVSEGKMNTTGQKGTNQETGIP GVFKTKKNPHLTTSNWDWTIDPIGLRIGLRRITSRYQLPVFITENGLGEFDKVEDGTV QDDYRIDYLRSHLEQCRQAISDGVDLIGYCSWSFTDLLSWLNGYQKRYGFVYVNRDEE STSDLKRLKKKSFYWYQDVIKTNGESL*" /label="bglC CDS" gene 351826..353259 /gene="bglC" /locus_tag="BSU_03410" /old_locus_tag="BSU03410" /label="bglC gene" downshifts 353237 /Source="Nicolas_upshifts" /id="D151" /incds=0 /nref=12 /ntot=61 /MaxReadThrough="1.51167" /MaxDrop="4.6748" /score="18.0928088" /energy="-15.9" /TU="NA" /idTUdmin="U260" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(353296..353694) /gene="nin" /locus_tag="BSU_03420" /old_locus_tag="BSU03420" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11359569, 11814663, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11359569, 11814663, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of the DNA degrading activity of NucA (competence)" /protein_id="NP_388224.1" /db_xref="EnsemblGenomes-Gn:BSU03420" /db_xref="EnsemblGenomes-Tr:CAB12136" /db_xref="GOA:P12669" /db_xref="InterPro:IPR020354" /db_xref="PDB:4MQD" /db_xref="SubtiList:BG10839" /db_xref="UniProtKB/Swiss-Prot:P12669" /translation="MIKSWKPQELSISYHQFTVFQKDSTPPVMDWTDEAIEKGYAAAD GAISFEAQRNTKAFILFRLNSSETVNSYEKKVTVPFHVTENGIHIESIMSKRLSFDLP KGDYQLTCWTVPAEMSDLHADTYIIDAVSV*" /label="nin CDS" gene complement(353296..353694) /gene="nin" /locus_tag="BSU_03420" /old_locus_tag="BSU03420" /label="nin gene" promotor_no_box complement(353691..353791) /Source="Nicolas_upshift_promotors" /id="U261" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.234765234765235" /psig="0.247752247752248" /xcortree=1715 /SigmaFactorBS="caggctcttgggtcgggcatcggcttaccgattacccagacg gcacaaaggttttattcacaattcagtaaacagtacatagaggaggaacagcacattg a" /listShort="nin, S122" /GFF_Attribute="listLong" /label="promotor_no_box" CDS complement(353721..354170) /gene="nucA" /locus_tag="BSU_03430" /old_locus_tag="BSU03430" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2841296, 7746143, 11359569, 11814663" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2841296, 7746143, 11359569, 11814663; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease" /protein_id="NP_388225.3" /db_xref="EnsemblGenomes-Gn:BSU03430" /db_xref="EnsemblGenomes-Tr:CAB12137" /db_xref="GOA:P12667" /db_xref="InterPro:IPR029476" /db_xref="SubtiList:BG10838" /db_xref="UniProtKB/Swiss-Prot:P12667" /translation="MNITTDIIKTILLVIVIIAAAAVGLIKGDFFSADQKTSQTKEYD ETMAFPSDRYPETAKHIKDAINEGHSEVCTIDRDGAEERREQSLKDVPSKKGYDRDEW PMAMCKEGGEGASVEYISPADNRGAGSWVGHRLTDYPDGTKVLFTIQ*" /label="nucA CDS" gene complement(353721..354170) /gene="nucA" /locus_tag="BSU_03430" /old_locus_tag="BSU03430" /label="nucA gene" upshifts complement(353731) /Source="Nicolas_upshifts" /id="U261" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.234765234765235" /psig="0.247752247752248" /xcortree=1715 /SigmaFactorBS="caggctcttgggtcgggcatcggcttaccgattacccagacg gcacaaaggttttattcacaattcagtaaacagtacatagaggaggaacagcacattg a" /listShort="nin, S122" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(354185..354204) /Source="Nicolas_upshift_promotors" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(354193) /Source="Nicolas_upshifts" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(354195..354337) /Source="Nicolas_S_feature" /locus_tag="new_372628_372770_c" /HighExp="C30, Diami, M40t45, Cold, Lbstat, T0.30H, M0t90, dia15, C90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigD" /TUshortPSig="0.0879, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S124" promotor_-35 complement(354218..354225) /Source="Nicolas_upshift_promotors" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(354338..356059) /gene="tlpC" /locus_tag="BSU_03440" /old_locus_tag="BSU03440" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7704255, 7921238, 15187186, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7704255, 7921238, 15187186, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein (plant colonization)" /protein_id="NP_388226.2" /db_xref="EnsemblGenomes-Gn:BSU03440" /db_xref="EnsemblGenomes-Tr:CAB12138" /db_xref="GOA:P39209" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="SubtiList:BG10790" /db_xref="UniProtKB/Swiss-Prot:P39209" /translation="MLIKRFKMKLGTKILCLVFVVILLFSASVGTVMLKEITESMKQM ATEKAKGDLALSSTYIDDVMSGDWQVKNNKLYKGQTQINGNEDIVDLLGEKTGDTITI FQGDTRVATNVMKNGERAVGTQASSEVIAAVLKKGKRFYGQADVAGSSYQTAYMPLKD QNGNIIGMLYTGANQSILASLTQSLFTQFAIVLVIVIMVSVILVLVFTRKINKRLNAL KSAFESAGNGDMTIEVSDKTGDELSELSVYYNKMRMKLNDTIQTVQQSALQLASASQQ LSAGAEETNQASEKITEAVQQIANGAQDQITRIENSESSLKQASADIRDISANTAAIA DKGQLAQSKADIGQKEIANVQAQMDAIHQSIQKSGEIIHQLDGRSKQIEQILSVITQI ADQTNLLALNAAIEAARAGEQGKGFAVVADEVRKLAEESQQSAGQISKLIIEIQKDMN RSARSVEHVKTEAAEGVTMIQRTRDAFKEIAAATGEISAEISDLSASVTNISASAHQI NDSFAANTADIKESTKNTRQAAALTEEQFAAMEEITAASETLSQLAEELTGIISQFKM INQAENG*" /label="tlpC CDS" gene complement(354338..356059) /gene="tlpC" /locus_tag="BSU_03440" /old_locus_tag="BSU03440" /label="tlpC gene" promotor_-35 354350..354357 /Source="Nicolas_upshift_promotors" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 354368..357511 /Source="Nicolas_S_feature" /locus_tag="new_372801_375944" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, T3.30H, T4.0H, T0.0H, T-0.40H" /AntisenseName="tlpC" /AntisenseCor="-0.40398083053643302" /AntisenseRegPval="-11.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S125" upshifts 354368 /Source="Nicolas_upshifts" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 354372..354391 /Source="Nicolas_upshift_promotors" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_no_box complement(354373..354473) /Source="Nicolas_upshift_promotors" /id="U264" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.452547452547453" /psig="0.0879120879120879" /xcortree=2190 /SigmaFactorBS="ggctgcattaacagaggagcaatttgctgcaatggaggagat taccgcagcttctgaaacactttctcaattagctgaggagcttaccggtatcataagc c" /listShort="S124, nucA, nin, S122" /listLong="yckB, yckA" /label="promotor_no_box" upshifts complement(354413) /Source="Nicolas_upshifts" /id="U264" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.452547452547453" /psig="0.0879120879120879" /xcortree=2190 /SigmaFactorBS="ggctgcattaacagaggagcaatttgctgcaatggaggagat taccgcagcttctgaaacactttctcaattagctgaggagcttaccggtatcataagc c" /listShort="S124, nucA, nin, S122" /listLong="yckB, yckA" /label="upshifts" promotor_-10 complement(356083..356101) /Source="Nicolas_upshift_promotors" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="promotor_-10" upshifts complement(356098) /Source="Nicolas_upshifts" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="upshifts" promotor_-35 complement(356115..356122) /Source="Nicolas_upshift_promotors" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="promotor_-35" CDS complement(356170..356727) /gene="hxlB" /locus_tag="BSU_03450" /old_locus_tag="BSU03450" /EC_number="5.3.1.27" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10572115, 15978081" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572115, 15978081; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-3-hexuloisomerase (PHI)" /protein_id="NP_388227.1" /db_xref="EnsemblGenomes-Gn:BSU03450" /db_xref="EnsemblGenomes-Tr:CAB12139" /db_xref="GOA:P42404" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR017552" /db_xref="PDB:1M3S" /db_xref="PDB:1VIV" /db_xref="SubtiList:BG11182" /db_xref="UniProtKB/Swiss-Prot:P42404" /translation="MKTTEYVAEILNELHNSAAYISNEEADQLADHILSSHQIFTAGA GRSGLMAKSFAMRLMHMGFNAHIVGEILTPPLAEGDLVIIGSGSGETKSLIHTAAKAK SLHGIVAALTINPESSIGKQADLIIRMPGSPKDQSNGSYKTIQPMGSLFEQTLLLFYD AVILKLMEKKGLDSETMFTHHANLE*" /label="hxlB CDS" gene complement(356170..356727) /gene="hxlB" /locus_tag="BSU_03450" /old_locus_tag="BSU03450" /label="hxlB gene" downshifts complement(356173) /Source="Nicolas_upshifts" /id="D152" /incds=0 /nref=51 /ntot=130 /MaxReadThrough="1.98332" /MaxDrop="6.56052" /score="42.3682356" /energy="-15.4" /TU="NA" /idTUdmin="U266" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(356733..357365) /gene="hxlA" /locus_tag="BSU_03460" /old_locus_tag="BSU03460" /EC_number="4.1.2.43" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10572115, 15978081" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572115, 15978081; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hexulose-6-phosphate synthase (HPS)" /protein_id="NP_388228.1" /db_xref="EnsemblGenomes-Gn:BSU03460" /db_xref="EnsemblGenomes-Tr:CAB12140" /db_xref="GOA:P42405" /db_xref="InterPro:IPR001754" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017553" /db_xref="SubtiList:BG11183" /db_xref="UniProtKB/Swiss-Prot:P42405" /translation="MELQLALDLVNIPEAIELVKEVEQYIDVVEIGTPVVINEGLRAV KEIKEAFPQLKVLADLKIMDAGGYEIMKASEAGADIITVLGATDDATIKGAVEEAKKQ KKKILVDMINVKDIESRAKEIDALGVDYICVHTGYDLQAEGKNSFEELTTIKNTVKNA KTAIAGGIKLDTLPEVIQQKPDLVIVGGGITSAADKAETASKMKQLIVQG*" /label="hxlA CDS" gene complement(356733..357365) /gene="hxlA" /locus_tag="BSU_03460" /old_locus_tag="BSU03460" /label="hxlA gene" promotor_-10 complement(357391..357410) /Source="Nicolas_upshift_promotors" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(357406) /Source="Nicolas_upshifts" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(357425..357428) /Source="Nicolas_upshift_promotors" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 357489..357492 /Source="Nicolas_upshift_promotors" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 357507..357526 /Source="Nicolas_upshift_promotors" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 357513 /Source="Nicolas_upshifts" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="upshifts" CDS 357599..357961 /gene="hxlR" /locus_tag="BSU_03470" /old_locus_tag="BSU03470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15978081, 26973631" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15978081, 26973631; Product type r: regulator" /codon_start=1 /transl_table=11 /product="positive regulator of hxlAB expression (formaldehyde sensing)" /protein_id="NP_388229.2" /db_xref="EnsemblGenomes-Gn:BSU03470" /db_xref="EnsemblGenomes-Tr:CAB12141" /db_xref="GOA:P42406" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11184" /db_xref="UniProtKB/Swiss-Prot:P42406" /translation="MSRMDDKRFNCEKELTLAVIGGKWKMLILWHLGKEGTKRFNELK TLIPDITQKILVNQLRELEQDMIVHREVYPVVPPKVEYSLTPHGESLMPILEAMYEWG KGYMELIDIDKNVMKESL*" /label="hxlR CDS" gene 357599..357961 /gene="hxlR" /locus_tag="BSU_03470" /old_locus_tag="BSU03470" /label="hxlR gene" downshifts 357945 /Source="Nicolas_upshifts" /id="D153" /incds=0 /nref=14 /ntot=154 /MaxReadThrough="3.13609" /MaxDrop="3.66949" /score="20.4643411" /energy="-9.6" /TU="U267" /idTUdmin="U263" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 358208..358211 /Source="Nicolas_upshift_promotors" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 358226..358245 /Source="Nicolas_upshift_promotors" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 358234..358534 /Source="Nicolas_S_feature" /locus_tag="new_376667_376967" /HighExp="HiOs, T-1.10H, T5.0H, T4.0H, T-1.40H, S2, M9-stat, T3.30H, T0.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.20585600000000001" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S126" upshifts 358234 /Source="Nicolas_upshifts" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="upshifts" CDS 358535..369298 /gene="srfAA" /locus_tag="BSU_03480" /old_locus_tag="BSU03480" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 8288534, 8441623, 14762003, 16707694, 26284661, 26268540, 14762003" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 8288534, 8441623, 14762003, 16707694, 26284661, 26268540, 14762003; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388230.2" /db_xref="EnsemblGenomes-Gn:BSU03480" /db_xref="EnsemblGenomes-Tr:CAB12142" /db_xref="GOA:P27206" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR013321" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10168" /db_xref="UniProtKB/Swiss-Prot:P27206" /translation="MEITFYPLTDAQKRIWYTEKFYPHTSISNLAGIGKLVSADAIDY VLVEQAIQEFIRRNDAMRLRLRLDENGEPVQYISEYRPVDIKHTDTTEDPNAIEFISQ WSREETKKPLPLYDCDLFRFSLFTIKENEVWFYANVHHVISDGISMNILGNAIMHIYL ELASGSETKEGISHSFIDHVLSEQEYAQSKRFEKDKAFWNKQFESVPELVSLKRNASA GGSLDAERFSKDVPEALHQQILSFCEANKVSVLSVFQSLLAAYLYRVSGQNDVVTGTF MGNRTNAKEKQMLGMFVSTVPLRTNIDGGQAFSEFVKDRMKDLMKTLRHQKYPYNLLI NDLRETKSSLTKLFTVSLEYQVMQWQKEEDLAFLTEPIFSGSGLNDVSIHVKDRWDTG KLTIDFDYRTDLFSREEINMICERMITMLENALTHPEHTIDELTLISDAEKEKLLARA GGKSVSYRKDMTIPELFQEKAELLSDHPAVVFEDRTLSYRTLHEQSARIANVLKQKGV GPDSPVAVLIERSERMITAIMGILKAGGAYVPIDPGFPAERIQYILEDCGADFILTES KVAAPEADAELIDLDQAIEEGAEESLNADVNARNLAYIIYTSGTTGRPKGVMIEHRQV HHLVESLQQTIYQSGSQTLRMALLAPFHFDASVKQIFASLLLGQTLYIVPKKTVTNGA ALTAYYRKNSIEATDGTPAHLQMLAAAGDFEGLKLKHMLIGGEGLSSVVADKLLKLFK EAGTAPRLTNVYGPTETCVDASVHPVIPENAVQSAYVPIGKALGNNRLYILDQKGRLQ PEGVAGELYIAGDGVGRGYLHLPELTEEKFLQDPFVPGDRMYRTGDVVRWLPDGTIEY LGREDDQVKVRGYRIELGEIEAVIQQAPDVAKAVVLARPDEQGNLEVCAYVVQKPGSE FAPAGLREHAARQLPDYMVPAYFTEVTEIPLTPSGKVDRRKLFALEVKAVSGTAYTAP RNETEKAIAAIWQDVLNVEKAGIFDNFFETGGHSLKAMTLLTKIHKETGIEIPLQFLF EHPTITALAEEADHRESKAFAVIEPAEKQEHYPLSLAQQRTYIVSQFEDAGVGYNMPA AAILEGPLDIQKLERAFQGLIRRHESLRTSFVLENSTPRQKIHDSVDFNIEMIERGGR SDEAIMASFVRTFDLAKAPLFRIGLLGLEENRHMLLFDMHHLISDGVSIGIMLEELAR IYKGEQLPDLRLQYKDYAVWQSRQAAEGYKKDQAYWKEVFAGELPVLQLLSDYPRPPV QSFEGDRVSIKLDAGVKDRLNRLAEQNGATLYMVMLSAYYTLLSKYTGQDDIIVGTPS AGRNHSDTEGIIGMFVNTLAIRSEVKQNETFTQLISRVRKRVLDAFSHQDYPFEWLVE DLNIPRDVSRHPLFDTMFSLQNATEGIPAVGDLSLSVQETNFKIAKFDLTVQARETDE GIEIDVDYSTKLFKQSTADRLLTHFARLLEDAAADPEKPISEYKLLSEEEAASQIQQF NPGRTPYPKDKTIVQLFEEQAANTPDHTALQYEGESLTYRELNERANRLARGILSLGA GEGRTAAVLCERSMDMIVSILAVLKSGSAYVPIDPEHPIQRMQHFFRDSGAKVLLTQR KLKALAEEAEFKGVIVLADEEESYHADARNLALPLDSAAMANLTYTSGTTGTPKGNIV THANILRTVKETNYLSITEQDTILGLSNYVFDAFMFDMFGSLLNGAKLVLIPKETVLD MARLSRVIERENISILMITTALFHLLVDLNPACLSTLRKIMFGGERASVEHVRKALQT VGKGKLLHMYGPSESTVFATYHPVDELEEHTLSVPIGKPVSNTEVYILDRTGHVQPAG IAGELCVSGEGLVKGYYNRPELTEEKFVPHPFTSGERMYKTGDLARWLPNGDIEFIGR IDHQVKIRGQRIELGEIEHQLQTHDRVQESVVLAVDQGAGDKLLCAYYVGEGDISSQE MREHAAKDLPAYMVPAVFIQMDELPLTGNGKIDRRALPIPDANVSRGVSYVAPRNGTE QKVADIWAQVLQAEQVGAYDHFFDIGGHSLAGMKMLALVHQELGVELSLKDLFQSPTV EGLAQVIASAEKGTAASISPAEKQDTYPVSSPQKRMYVLQQLEDAQTSYNMPAVLRLT GELDVERLNSVMQQLMQRHEALRTTFEIKDGETVQRIWEEAECEIAYFEAPEEETERI VSEFIKPFKIDQLPLFRIGLIKHSDTEHVLLFDMHHIISDGASVGVLIEELSKLYDGE TLEPLRIQYKDYAVWQQQFIQSELYKKQEEHWLKELDGELPVLTLPTDYSRPAVQTFE GDRIAFSLEAGKADALRRLAKETDSTLYMVLLASYSAFLSKISGQDDIIVGSPVAGRS QADVSRVIGMFVNTLALRTYPKGEKTFADYLNEVKETALSAFDAQDYPLEDLIGNVQV QRDTSRNPLFDAVFSMQNANIKDLTMKGIQLEPHPFERKTAKFDLTLTADETDGGLTF VLEYNTALFKQETIERWKQYWMELLDAVTGNPNQPLSSLSLVTETEKQALLEAWKGKA LPVPTDKTVHQLFEETAQRHKDRPAVTYNGQSWTYGELNAKANRLARILMDCGISPDD RVGVLTKPSLEMSAAVLGVLKAGAAFVPIDPDYPDQRIEYILQDSGAKLLLKQEGISV PDSYTGDVILLDGSRTILSLPLDENDEENPETAVTAENLAYMIYTSGTTGQPKGVMVE HHALVNLCFWHHDAFSMTAEDRSAKYAGFGFDASIWEMFPTWTIGAELHVIEEAIRLD IVRLNDYFETNGVTITFLPTQLAEQFMELENTSLRVLLTGGDKLKRAVKKPYTLVNNY GPTENTVVATSAEIHPEEGSLSIGRAIANTRVYILGEGNQVQPEGVAGELCVAGRGLA RGYLNREDETAKRFVADPFVPGERMYRTGDLVKWTGGGIEYIGRIDQQVKVRGYRIEL SEIEVQLAQLSEVQDAAVTAVKDKGGNTAIAAYVTPESADIEALKSALKETLPDYMIP AFWVTLNELPVTANGKVDRKALPEPDIEAGSGEYKAPTTDMEELLAGIWQDVLGMSEV GVTDNFFSLGGDSIKGIQMASRLNQHGWKLEMKDLFQHPTIEELTQYVERAEGKQADQ GPVEGEVILTPIQRWFFEKNFTNKHHWNQSVMLHAKKGFDPERVEKTLQALIEHHDAL RMVYREGQEDVIQYNRGLEAASAQLEVIQIEGQAADYEDRIEREAERLQSSIDLQEGG LLKAGLFQAEDGDHLLLAIHHLVVDGVSWRILLEDFAAVYTQLEQGNEPVLPQKTHSF AEYAERLQDFANSKAFLKEKEYWRQLEEQAVAAKLPKDRESGDQRMKHTKTIEFSLTA EETEQLTTKVHEAYHTEMNDILLTAFGLAMKEWTGQDRVSVHLEGHGREEIIEDLTIS RTVGWFTSMYPMVLDMKHADDLGYQLKQMKEDIRHVPNKGVGYGILRYLTAPEHKEDV AFSIQPDVSFNYLGQFDEMSDAGLFTRSELPSGQSLSPETEKPNALDVVGYIENGKLT MSLAYHSLEFHEKTVQTFSDSFKAHLLRIIEHCLSQDGTELTPSDLGDDDLTLDELDK LMEIF*" /label="srfAA CDS" gene 358535..369298 /gene="srfAA" /locus_tag="BSU_03480" /old_locus_tag="BSU03480" /label="srfAA gene" CDS 369311..380062 /gene="srfAB" /locus_tag="BSU_03490" /old_locus_tag="BSU03490" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 16553878, 17227471, 14762003, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 16553878, 17227471, 14762003, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388231.2" /db_xref="EnsemblGenomes-Gn:BSU03490" /db_xref="EnsemblGenomes-Tr:CAB12143" /db_xref="GOA:Q04747" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10169" /db_xref="UniProtKB/Swiss-Prot:Q04747" /translation="MSKKSIQKVYALTPMQEGMLYHAMLDPHSSSYFTQLELGIHGAF DLEIFEKSVNELIRSYDILRTVFVHQQLQKPRQVVLAERKTKVHYEDISHADENRQKE HIERYKQDVQRQGFNLAKDILFKVAVFRLAADQLYLVWSNHHIMMDGWSMGVLMKSLF QNYEALRAGRTPANGQGKPYSDYIKWLGKQDNEEAESYWSERLAGFEQPSVLPGRLPV KKDEYVNKEYSFTWDETLVARIQQTANLHQVTGPNLFQAVWGIVLSKYNFTDDVIFGT VVSGRPSEINGIETMAGLFINTIPVRVKVERDAAFADIFTAVQQHAVEAERYDYVPLY EIQKRSALDGNLLNHLVAFENYPLDQELENGSMEDRLGFSIKVESAFEQTSFDFNLIV YPGKTWTVKIKYNGAAFDSAFIERTAEHLTRMMEAAVDQPAAFVREYGLVGDEEQRQI VEVFNSTKAELPEGMAVHQVFEEQAKRTPASTAVVYEGTKLTYRELNAAANRLARKLV EHGLQKGETAAIMNDRSVETVVGMLAVLKAGAAYVPLDPALPGDRLRFMAEDSSVRMV LIGNSYTGQAHQLQVPVLTLDIGFEESEAADNLNLPSAPSDLAYIMYTSGSTGKPKGV MIEHKSILRLVKNAGYVPVTEEDRMAQTGAVSFDAGTFEVFGALLNGAALYPVKKETL LDAKQFAAFLREQSITTMWLTSPLFNQLAAKDAGMFGTLRHLIIGGDALVPHIVSKVK QASPSLSLWNGYGPTENTTFSTSFLIDREYGGSIPIGKPIGNSTAYIMDEQQCLQPIG APGELCVGGIGVARGYVNLPELTEKQFLEDPFRPGERIYRTGDLARWLPDGNIEFLGR IDNQVKVRGFRIELGEIETKLNMAEHVTEAAVIIRKNKADENEICAYFTADREVAVSE LRKTLSQSLPDYMVPAHLIQMDSLPLTPNGKINKKELPAPQSEAVQPEYAAPKTESEK KLAEIWEGILGVKAGVTDNFFMIGGHSLKAMMMTAKIQEHFHKEVPIKVLFEKPTIQE LALYLEENESKEEQTFEPIRQASYQQHYPVSPAQRRMYILNQLGQANTSYNVPAVLLL EGEVDKDRLENAIQQLINRHEILRTSFDMIDGEVVQTVHKNISFQLEAAKGREEDAEE IIKAFVQPFELNRAPLVRSKLVQLEEKRHLLLIDMHHIITDGSSTGILIGDLAKIYQG ADLELPQIHYKDYAVWHKEQTNYQKDEEYWLDVFKGELPILDLPADFERPAERSFAGE RVMFGLDKQITAQIKSLMAETDTTMYMFLLAAFNVLLSKYASQDDIIVGSPTAGRTHP DLQGVPGMFVNTVALRTAPAGDKTFAQFLEEVKTASLQAFEHQSYPLEELIEKLPLTR DTSRSPLFSVMFNMQNMEIPSLRLGDLKISSYSMLHHVAKFDLSLEAVEREEDIGLSF DYATALFKDETIRRWSRHFVNIIKAAAANPNVRLSDVDLLSSAETAALLEERHMTQIT EATFAALFEKQAQQTPDHSAVKAGGNLLTYRELDEQANQLAHHLRAQGAGNEDIVAIV MDRSAEVMVSILGVMKAGAAFLPIDPDTPEERIRYSLEDSGAKFAVVNERNMTAIGQY EGIIVSLDDGKWRNESKERPSSISGSRNLAYVIYTSGTTGKPKGVQIEHRNLTNYVSW FSEEAGLTENDKTVLLSSYAFDLGYTSMFPVLLGGGELHIVQKETYTAPDEIAHYIKE HGITYIKLTPSLFHTIVNTASFAKDANFESLRLIVLGGEKIIPTDVIAFRKMYGHTEF INHYGPTEATIGAIAGRVDLYEPDAFAKRPTIGRPIANAGALVLNEALKLVPPGASGQ LYITGQGLARGYLNRPQLTAERFVENPYSPGSLMYKTGDVVRRLSDGTLAFIGRADDQ VKIRGYRIEPKEIETVMLSLSGIQEAVVLAVSEGGLQELCAYYTSDQDIEKAELRYQL SLTLPSHMIPAFFVQVDAIPLTANGKTDRNALPKPNAAQSGGKALAAPETALEESLCR IWQKTLGIEAIGIDDNFFDLGGHSLKGMMLIANIQAELEKSVPLKALFEQPTVRQLAA YMEASAVSGGHQVLKPADKQDMYPLSSAQKRMYVLNQLDRQTISYNMPSVLLMEGELD ISRLRDSLNQLVNRHESLRTSFMEANGEPVQRIIEKAEVDLHVFEAKEDEADQKIKEF IRPFDLNDAPLIRAALLRIEAKKHLLLLDMHHIIADGVSRGIFVKELALLYKGEQLPE PTLHYKDFAVWQNEAEQKERMKEHEAYWMSVLSGELPELDLPLDYARPPVQSFKGDTI RFRTGSETAKAVEKLLAETGTTLHMVLHAVFHVFLSKISGQRDIVIGSVTAGRTNADV QDMPGMFVNTLALRMEAKEQQTFAELLELAKQTNLSALEHQEYPFEDLVNQLDLPRDM SRNPLFNVMVTTENPDKEQLTLQNLSISPYEAHQGTSKFDLTLGGFTDENGIGLQLEY ATDLFAKETAEKWSEYVLRLLKAVADNPNQPLSSLLLVTETEKQALLEAWKGKALPVP TDKTVHQLFEETVQRHKDRPAVTYNGQSWTYGELNAKANRLARILMDCGISPDDRVGV LTKPSLEMSAAVLGVLKAGAAFVPIDPDYPDQRIEYILQDSGAKLLLKQEGISVPDSY TGDVILLDGSRTILSLPLDENDEGNPETAVTAENLAYMIYTSGTTGQPKGVMVEHHAL VNLCFWHHDAFSMTAEDRSAKYAGFGFDASIWEMFPTWTIGAELHVIDEAIRLDIVRL NDYFETNGVTITFLPTQLAEQFMELENTSLRVLLTGGDKLKRAVKKPYTLVNNYGPTE NTVVATSAEIHPEEGSLSIGRAIANTRVYILGEGNQVQPEGVAGELCVAGRGLARGYL NREDETAKRFVADPFVPGERMYRTGDLVKWVNGGIEYIGRIDQQVKVRGYRIELSEIE VQLAQLSEVQDAAVTAVKDKGGNTAIAAYVTPETADIEALKSTLKETLPDYMIPAFWV TLNELPVTANGKVDRKALPEPDIEAGSGEYKAPTTDMEELLAGIWQDVLGMSEVGVTD NFFSLGGDSIKGIQMASRLNQHGWKLEMKDLFQHPTIEELTQYVERAEGKQADQGPVE GEVILTPIQRWFFEKNFTNKHHWNQSVMLHAKKGFDPERVEKTLQALIEHHDALRMVY REENGDIVQVYKPIGESKVSFEIVDLYGSDEEMLRSQIKLLANKLQSSLDLRNGPLLK AEQYRTEAGDHLLIAVHHLVVDGVSWRILLEDFASGYMQAEKEESLVFPQKTNSFKDW AEELAAFSQSAHLLQQAEYWSQIAAEQVSPLPKDCETEQRIVKDTSSVLCELTAEDTK HLLTDVHQPYGTEINDILLSALGLTMKEWTKGAKIGINLEGHGREDIIPNVNISRTVG WFTAQYPVVLDISDADASAVIKTVKENLRRIPDKGVGYGILRYFTETAETKGFTPEIS FNYLGQFDSEVKTDFFEPSAFDMGRQVSGESEALYALSFSGMIRNGRFVLSCSYNEKE FERATVEEQMERFKENLLMLIRHCTEKEDKEFTPSDFSAEDLEMDEMGDIFDMLEENL K*" /label="srfAB CDS" gene 369311..380062 /gene="srfAB" /locus_tag="BSU_03490" /old_locus_tag="BSU03490" /label="srfAB gene" CDS 372447..372587 /gene="comS" /locus_tag="BSU_03500" /old_locus_tag="BSU03500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10361283, 16554821, 8752331, 9696775, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10361283, 16554821, 8752331, 9696775, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of genetic competence" /protein_id="NP_388232.1" /db_xref="EnsemblGenomes-Gn:BSU03500" /db_xref="EnsemblGenomes-Tr:CAB12144" /db_xref="GOA:P80355" /db_xref="InterPro:IPR035139" /db_xref="SubtiList:BG11045" /db_xref="UniProtKB/Swiss-Prot:P80355" /translation="MNRSGKHLISSIILYPRPSGECISSISLDKQTQATTSPLYFCWR EK*" /label="comS CDS" gene 372447..372587 /gene="comS" /locus_tag="BSU_03500" /old_locus_tag="BSU03500" /label="comS gene" CDS 380099..383926 /gene="srfAC" /locus_tag="BSU_03510" /old_locus_tag="BSU03510" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 16553878, 17227471, 14762003, 22720735, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 16553878, 17227471, 14762003, 22720735, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388233.2" /db_xref="EnsemblGenomes-Gn:BSU03510" /db_xref="EnsemblGenomes-Tr:CAB12145" /db_xref="GOA:Q08787" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR036736" /db_xref="PDB:1JMK" /db_xref="PDB:2VSQ" /db_xref="SubtiList:BG10170" /db_xref="UniProtKB/Swiss-Prot:Q08787" /translation="MSQFSKDQVQDMYYLSPMQEGMLFHAILNPGQSFYLEQITMKVK GSLNIKCLEESMNVIMDRYDVFRTVFIHEKVKRPVQVVLKKRQFHIEEIDLTHLTGSE QTAKINEYKEQDKIRGFDLTRDIPMRAAIFKKAEESFEWVWSYHHIILDGWCFGIVVQ DLFKVYNALREQKPYSLPPVKPYKDYIKWLEKQDKQASLRYWREYLEGFEGQTTFAEQ RKKQKDGYEPKELLFSLSEAETKAFTELAKSQHTTLSTALQAVWSVLISRYQQSGDLA FGTVVSGRPAEIKGVEHMVGLFINVVPRRVKLSEGITFNGLLKRLQEQSLQSEPHQYV PLYDIQSQADQPKLIDHIIVFENYPLQDAKNEESSENGFDMVDVHVFEKSNYDLNLMA SPGDEMLIKLAYNENVFDEAFILRLKSQLLTAIQQLIQNPDQPVSTINLVDDREREFL LTGLNPPAQAHETKPLTYWFKEAVNANPDAPALTYSGQTLSYRELDEEANRIARRLQK HGAGKGSVVALYTKRSLELVIGILGVLKAGAAYLPVDPKLPEDRISYMLADSAAACLL THQEMKEQAAELPYTGTTLFIDDQTRFEEQASDPATAIDPNDPAYIMYTSGTTGKPKG NITTHANIQGLVKHVDYMAFSDQDTFLSVSNYAFDAFTFDFYASMLNAARLIIADEHT LLDTERLTDLILQENVNVMFATTALFNLLTDAGEDWMKGLRCILFGGERASVPHVRKA LRIMGPGKLINCYGPTEGTVFATAHVVHDLPDSISSLPIGKPISNASVYILNEQSQLQ PFGAVGELCISGMGVSKGYVNRADLTKEKFIENPFKPGETLYRTGDLARWLPDGTIEY AGRIDDQVKIRGHRIELEEIEKQLQEYPGVKDAVVVADRHESGDASINAYLVNRTQLS AEDVKAHLKKQLPAYMVPQTFTFLDELPLTTNGKVNKRLLPKPDQDQLAEEWIGPRNE MEETIAQIWSEVLGRKQIGIHDDFFALGGHSLKAMTAASRIKKELGIDLPVKLLFEAP TIAGISAYLKNGGSDGLQDVTIMNQDQEQIIFAFPPVLGYGLMYQNLSSRLPSYKLCA FDFIEEEDRLDRYADLIQKLQPEGPLTLFGYSAGCSLAFEAAKKLEEQGRIVQRIIMV DSYKKQGVSDLDGRTVESDVEALMNVNRDNEALNSEAVKHGLKQKTHAFYSYYVNLIS TGQVKADIDLLTSGADFDMPEWLASWEEATTGVYRVKRGFGTHAEMLQGETLDRNAEI LLEFLNTQTVTVS*" /label="srfAC CDS" gene 380099..383926 /gene="srfAC" /locus_tag="BSU_03510" /old_locus_tag="BSU03510" /label="srfAC gene" CDS 383955..384683 /gene="srfAD" /locus_tag="BSU_03520" /old_locus_tag="BSU03520" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16166527, 16553878, 17227471, 14762003, 22720735, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16166527, 16553878, 17227471, 14762003, 22720735, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388234.1" /db_xref="EnsemblGenomes-Gn:BSU03520" /db_xref="EnsemblGenomes-Tr:CAB12146" /db_xref="GOA:Q08788" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR012223" /db_xref="InterPro:IPR029058" /db_xref="PDB:2K2Q" /db_xref="PDB:2RON" /db_xref="SubtiList:BG10171" /db_xref="UniProtKB/Swiss-Prot:Q08788" /translation="MSQLFKSFDASEKTQLICFPFAGGYSASFRPLHAFLQGECEMLA AEPPGHGTNQTSAIEDLEELTDLYKQELNLRPDRPFVLFGHSMGGMITFRLAQKLERE GIFPQAVIISAIQPPHIQRKKVSHLPDDQFLDHIIQLGGMPAELVENKEVMSFFLPSF RSDYRALEQFELYDLAQIQSPVHVFNGLDDKKCIRDAEGWKKWAKDITFHQFDGGHMF LLSQTEEVAERIFAILNQHPIIQP*" /label="srfAD CDS" gene 383955..384683 /gene="srfAD" /locus_tag="BSU_03520" /old_locus_tag="BSU03520" /label="srfAD gene" downshifts 384665 /Source="Nicolas_upshifts" /id="D154" /incds=0 /nref=196 /ntot=261 /MaxReadThrough="4.65721" /MaxDrop="6.48992" /score="24.9581454" /energy="-11.1" /TU="U268" /idTUdmin="U268" /TUdmin="-1339" /isTUend="FALSE" /label="downshifts" promotor_-35 384721..384728 /Source="Nicolas_upshift_promotors" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 384731 /Source="Nicolas_upshifts" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 384740..384759 /Source="Nicolas_upshift_promotors" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 384784..386010 /gene="srfT" /locus_tag="BSU_03530" /old_locus_tag="BSU03530" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15849754, 16850406, 25366377; Product type t: transporter" /codon_start=1 /transl_table=11 /product="surfactin exporter" /protein_id="NP_388235.2" /db_xref="EnsemblGenomes-Gn:BSU03530" /db_xref="EnsemblGenomes-Tr:CAB12147" /db_xref="GOA:Q08791" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10172" /db_xref="UniProtKB/Swiss-Prot:Q08791" /translation="MRTSPRMKWFVLLFTFVFAIGMNSFRNSFQFFMLPMADAFHADR SLISVSVSIFMITTGIVQFFVGFFIDRFSVRKIMALGAVCISASFLVLPYSPNVHVFS AIYGVLGGIGYSCAVGVTTQYFISCWFDTHKGLALAILTNANSAGLLLLSPIWAAAPY HAGWQSTYTILGIVMAAVLLPLLVFGMKHPPHAQAETVKKSYDWRGFWNVMKQSRLIH ILYFGVFTCGFTMGIIDAHLVPILKDAHVSHVNGMMAAFGAFIIIGGLLAGWLSDLLG SRSVMLSILFFIRLLSLICLLIPILGIHHSDLWYFGFILLFGLSYTGVIPLTAASISE SYQTGLIGSLLGINFFIHQVAGALSVYAGGLFFDMTHGYLLIVAVCIVFVGLSAVIEL VPFLDKQKAKETHHSI*" /label="srfT CDS" gene 384784..386010 /gene="srfT" /locus_tag="BSU_03530" /old_locus_tag="BSU03530" /label="srfT gene" downshifts 386004 /Source="Nicolas_upshifts" /id="D155" /incds=0 /nref=15 /ntot=198 /MaxReadThrough="2.67601" /MaxDrop="4.06773" /score="7.33278866" /energy="-13.2" /TU="NA" /idTUdmin="U268" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(386025..386582) /gene="ycxB" /locus_tag="BSU_03540" /old_locus_tag="BSU03540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 21965396" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388236.1" /db_xref="EnsemblGenomes-Gn:BSU03540" /db_xref="EnsemblGenomes-Tr:CAB12148" /db_xref="GOA:Q08793" /db_xref="InterPro:IPR025588" /db_xref="SubtiList:BG10173" /db_xref="UniProtKB/Swiss-Prot:Q08793" /translation="MIQYASESINLPGEITFKDVREIFFYQIAKISCFYFLLFCAIFA AVNFINGWPRIVYGSDALNLFMNSMLIIVMSVLFTLLLLLLLYVKFSRAYKKNERMKS KRTYTLNQEGIRICSKKYDLIFNWDEITAVFEYKNIFRVNTSSGQYIAIPKHFFHSEE EMNRFKEIILKNTETKKLKFKKDQH*" /label="ycxB CDS" gene complement(386025..386582) /gene="ycxB" /locus_tag="BSU_03540" /old_locus_tag="BSU03540" /label="ycxB gene" promotor_no_box complement(386040..386140) /Source="Nicolas_upshift_promotors" /id="U270" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.024975024975025" /xcortree=283 /SigmaFactorBS="atattgcgatccccaaacatttttttcactccgaagaggaga tgaacagattcaaggagattatccttaaaaataccgaaacaaaaaaactcaaatttaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" downshifts complement(386062) /Source="Nicolas_upshifts" /id="D156" /incds=0 /nref=46 /ntot=241 /MaxReadThrough="0.9216" /MaxDrop="4.25654" /score="8.42655219" /energy="-14.3" /TU="U270" /idTUdmin="U271" /TUdmin=18 /isTUend="TRUE" /label="downshifts" upshifts complement(386080) /Source="Nicolas_upshifts" /id="U270" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.024975024975025" /xcortree=283 /SigmaFactorBS="atattgcgatccccaaacatttttttcactccgaagaggaga tgaacagattcaaggagattatccttaaaaataccgaaacaaaaaaactcaaatttaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(386611..386630) /Source="Nicolas_upshift_promotors" /id="U271" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=3105 /SigmaFactorBS="aaaaaacaaagcgccctggtatgcctgcaaaaaaatgagaaa tTATGCTAGACTAAAAGGAAAaacatggttagaggtgtaggtttaccgtatgattcaa t" /listShort="ycxB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(386613) /Source="Nicolas_upshifts" /id="U271" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=3105 /SigmaFactorBS="aaaaaacaaagcgccctggtatgcctgcaaaaaaatgagaaa tTATGCTAGACTAAAAGGAAAaacatggttagaggtgtaggtttaccgtatgattcaa t" /listShort="ycxB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(386636..387574) /gene="ycxC" /locus_tag="BSU_03550" /old_locus_tag="BSU03550" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388237.2" /db_xref="EnsemblGenomes-Gn:BSU03550" /db_xref="EnsemblGenomes-Tr:CAB12149" /db_xref="GOA:Q08794" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG10174" /db_xref="UniProtKB/Swiss-Prot:Q08794" /translation="MVKHQQTPAYIAAILYSFIIGLSFLFVKIALQTAEPFDILAHRF TIAFAAATVPILFGWVKLSIRVKDVIDILPLALLYPALFFSFQAFGLVYSSSSEAGII QAAIPIFTMVFAAYVLKERPTWTQKGFTVLSVAGVMFIFVMKGVDVESASLKGSLLIL LSALSSAMYNTAARKMTQRFKLTELTYIMSAIGFVVFNAIALVRHGAAGTVGTYFLPF REPGFVLAIVYLGVLSSLVTSFLSNYTLSRIEAFKMSAFNHVSTIVTMIAGFVILNES LAWYHLAGAVCIMIGVVGSNINLEKKTKRPGMPAKK*" /label="ycxC CDS" gene complement(386636..387574) /gene="ycxC" /locus_tag="BSU_03550" /old_locus_tag="BSU03550" /label="ycxC gene" promotor_-10 complement(387613..387631) /Source="Nicolas_upshift_promotors" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(387620) /Source="Nicolas_upshifts" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(387647..387652) /Source="Nicolas_upshift_promotors" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 387698..389032 /gene="ycxD" /locus_tag="BSU_03560" /old_locus_tag="BSU03560" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 26585522; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388238.1" /db_xref="EnsemblGenomes-Gn:BSU03560" /db_xref="EnsemblGenomes-Tr:CAB12150" /db_xref="GOA:Q08792" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10175" /db_xref="UniProtKB/Swiss-Prot:Q08792" /translation="MEKYMSLLTRIEEMMQSTSYQEGDRLPSIRQLSARYQVSKSTVI RALQELEKRHLIYSVPKSGYYIVKKSGKSKSGQPGPIDFATSAPDPDVFPYLDFQHCI NKAIDTYKNDLFIYGTPKGLPSLIRVLRKLLATQQVFADERHIFITSGVQQALSLLCA MPFPNGKEKIAIEQPGYHLMVEQLETLGIPAIGVKRTEEGLDIAKVERLFQTESIKFF YTMPRFHNPLGCSLSERDKQELVRLAEAYDVYLVEDDYLGDLEENKKADPLYAYDLSS HVIYLKSFSKMMFPGLRVGAAVLPEALTDTFYAYKKLNDIDCSMISQAALEIYLKSGM YGRHKEKIRDSYKERSLRLHQAIRTHRQLGSGRFTFSSGQAPCMHTHLVLPQDLPASR VIHRLEKQGVLLEAIDRHYLSDYPKENLLKINISNVKTEDIERGVKLLMSHL*" /label="ycxD CDS" gene 387698..389032 /gene="ycxD" /locus_tag="BSU_03560" /old_locus_tag="BSU03560" /label="ycxD gene" CDS complement(389027..389194) /gene="sfpAc" /locus_tag="BSU_03569" /old_locus_tag="BSU03569" /EC_number="2.7.8.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10568751, 17376553, 2848009, 9384377, 14762003, 16707694, 19061923, 20971906, 25288929, 26268540; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="C-terminal part of 4'-phosphopantetheinyl transferase (Surfactin synthetase-activating enzyme)" /db_xref="PSEUDO:CAX52545.1" /translation="MRLHQDGQVSIELPDSHSPCYIKTYEVDPGYKMAVCAVHPDFPE DITMVSYEELL*" /label="sfpAc CDS" gene complement(389027..389194) /gene="sfpAc" /locus_tag="BSU_03569" /old_locus_tag="BSU03569" /pseudo /label="sfpAc gene" CDS complement(389205..389702) /gene="sfpAn" /locus_tag="BSU_03570" /old_locus_tag="BSU03570" /EC_number="2.7.8.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10568751, 17376553, 2848009, 9384377, 14762003, 16707694, 19061923, 20971906, 25288929, 26268540; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="N-terminal part of 4'-phosphopantetheinyl transferase (surfactin synthetase-activating enzyme)" /db_xref="GOA:P39135" /db_xref="InterPro:IPR004568" /db_xref="InterPro:IPR008278" /db_xref="InterPro:IPR037143" /db_xref="PDB:1QR0" /db_xref="PDB:2GE0" /db_xref="PDB:2GE1" /db_xref="PDB:4MRT" /db_xref="PSEUDO:CAB12151.2" /db_xref="SubtiList:BG10176" /db_xref="UniProtKB/Swiss-Prot:P39135" /translation="MKIYGIYMDRPLSQEENERFMSFISPEKREKCRRFYHKEDAHRT LLGDVLVRSVISRQYQLDKSDIRFSTQEYGKPCIPDLPDAHFNISHSGRWVICAFDSQ PIGIDIEKTKPISLEIAKRFFSKTEYSDLLAKDKDEQTDYFYHLWSMKESFIKQGRQR LIASA*" /label="sfpAn CDS" gene complement(389205..389702) /gene="sfpAn" /locus_tag="BSU_03570" /old_locus_tag="BSU03570" /pseudo /label="sfpAn gene" misc_feature complement(389729..389748) /Source="Nicolas_upshift_promotors" /id="U273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2243 /SigmaFactorBS="agccgccttggctttgtttttttattttctcctctatatgag tcttgtggaagTATGATAGGATGGTTTTGACaatcttttgcagacggaggatctagaa t" /listShort="sfp, sfp" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(389741) /Source="Nicolas_upshifts" /id="U273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2243 /SigmaFactorBS="agccgccttggctttgtttttttattttctcctctatatgag tcttgtggaagTATGATAGGATGGTTTTGACaatcttttgcagacggaggatctagaa t" /listShort="sfp, sfp" /GFF_Attribute="listLong" /label="upshifts" CDS complement(389807..390454) /gene="yczE" /locus_tag="BSU_03580" /old_locus_tag="BSU03580" /function="15.11: Biosynthesis of natural products" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 17827323, 14762003, 16707694, 17827323, 25288929; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="integral inner membrane protein regulating antibiotic production" /protein_id="NP_388240.2" /db_xref="EnsemblGenomes-Gn:BSU03580" /db_xref="EnsemblGenomes-Tr:CAB12152" /db_xref="GOA:O34927" /db_xref="SubtiList:BG12779" /db_xref="UniProtKB/Swiss-Prot:O34927" /translation="MKQELVLRWTFYFAGLIILAFGVSLTIEGKALGISPWDAFHYSL FQHFGLTVGQWSIIIGALIVGFTSLFTRAWPKIGALLNMVLIGVFIDFFNFILPALST YTGSIIVFSLGVVLIGYGVGVYVSAGLGAGPRDSLMMLITEKTGWNVQWVRNGMELTI LFAAWGMGGPIGFGTILTAILTGLILRFSLPQSIQLLNYAVARRTAAVKASPPVH*" /label="yczE CDS" gene complement(389807..390454) /gene="yczE" /locus_tag="BSU_03580" /old_locus_tag="BSU03580" /label="yczE gene" promotor_-10 complement(390483..390502) /Source="Nicolas_upshift_promotors" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(390486) /Source="Nicolas_upshifts" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(390518..390522) /Source="Nicolas_upshift_promotors" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(390623..390774) /Source="Nicolas_S_feature" /locus_tag="new_409056_409207_c" /HighExp="G180, G135, dia15, H2O2, Diami, S8, Oxctl, G150, LPhT, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S127" CDS complement(390775..391518) /gene="tcyC" /locus_tag="BSU_03590" /old_locus_tag="BSU03590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 16513748, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 16513748, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (ATP-binding protein)" /protein_id="NP_388241.2" /db_xref="EnsemblGenomes-Gn:BSU03590" /db_xref="EnsemblGenomes-Tr:CAB12153" /db_xref="GOA:P39456" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11185" /db_xref="UniProtKB/Swiss-Prot:P39456" /translation="MLTVKGLNKSFGENEILKKIDMKIEKGKVIAILGPSGSGKTTLL RCLNALEIPNRGELAFDDFSIDFSKKVKQADILKLRRKSGMVFQAYHLFPHRTALENV MEGPVQVQKRNKEEVRKEAIQLLDKVGLKDKMDLYPFQLSGGQQQRVGIARALAIQPE LMLFDEPTSALDPELVGEVLKVIKDLANEGWTMVVVTHEIKFAQEVADEVIFIDGGVI VEQGPPEQIFSAPKEERTQRFLNRILNPL*" /label="tcyC CDS" gene complement(390775..391518) /gene="tcyC" /locus_tag="BSU_03590" /old_locus_tag="BSU03590" /label="tcyC gene" downshifts complement(390831) /Source="Nicolas_upshifts" /id="D157" /incds=0 /nref=72 /ntot=232 /MaxReadThrough="4.60958" /MaxDrop="4.44283" /score="1.62131565" /energy="-12.6" /TU="U275" /idTUdmin="U276" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(391532..392236) /gene="tcyB" /locus_tag="BSU_03600" /old_locus_tag="BSU03600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 15849754, 16850406, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 15849754, 16850406, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (permease)" /protein_id="NP_388242.1" /db_xref="EnsemblGenomes-Gn:BSU03600" /db_xref="EnsemblGenomes-Tr:CAB12154" /db_xref="GOA:P42200" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11186" /db_xref="UniProtKB/Swiss-Prot:P42200" /translation="MFLNNLPALTLGTAIPWDLVQQSFWPILSGGIYYTIPLTILSFI FGMILALITALARMSKVRPLRWVFSVYVSAIRGTPLLVQLFIIFYLFPAFNVTLDPFP SAVIAFSLNVGAYASEIIRASILSVPKGQWEAGYTIGMTHQKTLFRVILPQAFRVSIP PLSNTFISLIKDTSLASQILVAELFRKAQEIGARNLDQILVIYIEAAFIYWIICFLLS LVQHVIERRLDRYVAK*" /label="tcyB CDS" gene complement(391532..392236) /gene="tcyB" /locus_tag="BSU_03600" /old_locus_tag="BSU03600" /label="tcyB gene" CDS complement(392223..393029) /gene="tcyA" /locus_tag="BSU_03610" /old_locus_tag="BSU03610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (substrate-binding lipoprotein)" /protein_id="NP_388243.2" /db_xref="EnsemblGenomes-Gn:BSU03610" /db_xref="EnsemblGenomes-Tr:CAB12155" /db_xref="GOA:P42199" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11187" /db_xref="UniProtKB/Swiss-Prot:P42199" /translation="MKKALLALFMVVSIAALAACGAGNDNQSKDNAKDGDLWASIKKK GVLTVGTEGTYEPFTYHDKDTDKLTGYDVEVITEVAKRLGLKVDFKETQWDSMFAGLN SKRFDVVANQVGKTDREDKYDFSDKYTTSRAVVVTKKDNNDIKSEADVKGKTSAQSLT SNYNKLATNAGAKVEGVEGMAQALQMIQQGRVDMTYNDKLAVLNYLKTSGNKNVKIAF ETGEPQSTYFTFRKGSGEVVDQVNKALKEMKEDGTLSKISKKWFGEDVSK*" /label="tcyA CDS" gene complement(392223..393029) /gene="tcyA" /locus_tag="BSU_03610" /old_locus_tag="BSU03610" /label="tcyA gene" promotor_-10 complement(393078..393097) /Source="Nicolas_upshift_promotors" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(393090) /Source="Nicolas_upshifts" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(393111..393118) /Source="Nicolas_upshift_promotors" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(393145..394017) /gene="bsdA" /locus_tag="BSU_03620" /old_locus_tag="BSU03620" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17295427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17295427; Product type r: regulator" /codon_start=1 /transl_table=11 /product="HTH-type transcriptional regulator BsdA (LysR family)" /protein_id="NP_388244.1" /db_xref="EnsemblGenomes-Gn:BSU03620" /db_xref="EnsemblGenomes-Tr:CAB12156" /db_xref="GOA:P94403" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12022" /db_xref="UniProtKB/Swiss-Prot:P94403" /translation="MDIRQLRYFITIAQEQKITSAAKKLHMAQPPLSRQLKQLEDELG VVLFDRNKKKQMTLTYEGAVFLKRAKEILHRFEDAVIEVQELKEEVAGTLAVGSTIYC AALMLEKVTQIKERYPHLTFNIWENEPATLLELLESRQIDAAVTTTLIKSDTVQFKQL DDIPCVLVLSDEAGYPCGDTIKMVDIPSFPLILLRPVNGKGVYNQVMNEFHRLNLEPR IVCECHDSATLLSLVSSGFGASILPVTMIPVHMRNHVHTVHIENNPFIMTPAVMWRTD SYLPKPAQQFLDLF*" /label="bsdA CDS" gene complement(393145..394017) /gene="bsdA" /locus_tag="BSU_03620" /old_locus_tag="BSU03620" /label="bsdA gene" promotor_-10 complement(393755..393773) /Source="Nicolas_upshift_promotors" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(393762) /Source="Nicolas_upshifts" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(393788..393794) /Source="Nicolas_upshift_promotors" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 394071..394078 /Source="Nicolas_upshift_promotors" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(394086..394105) /Source="Nicolas_upshift_promotors" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="promotor_-10" promotor_-10 394092..394111 /Source="Nicolas_upshift_promotors" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(394092) /Source="Nicolas_upshifts" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="upshifts" upshifts 394100 /Source="Nicolas_upshifts" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="upshifts" CDS 394107..394721 /gene="ubiX" /locus_tag="BSU_03630" /old_locus_tag="BSU03630" /EC_number="4.1.1.-" /EC_number="4.1.1.61" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10919793, 15979273, 17295427, 18388975, 26083743, 26658822, 26337367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase-flavin prenyltransferase subunit" /protein_id="NP_388245.1" /db_xref="EnsemblGenomes-Gn:BSU03630" /db_xref="EnsemblGenomes-Tr:CAB12157" /db_xref="GOA:P94404" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR004507" /db_xref="InterPro:IPR032901" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG12023" /db_xref="UniProtKB/Swiss-Prot:P94404" /translation="MKAEFKRKGGGKVKLVVGMTGATGAIFGVRLLQWLKAAGVETHL VVSPWANVTIKHETGYTLQEVEQLATYTYSHKDQAAAISSGSFDTDGMIVAPCSMKSL ASIRTGMADNLLTRAADVMLKERKKLVLLTRETPLNQIHLENMLALTKMGTIILPPMP AFYNRPRSLEEMVDHIVFRTLDQFGIRLPEAKRWNGIEKQKGGA*" /label="ubiX CDS" gene 394107..394721 /gene="ubiX" /locus_tag="BSU_03630" /old_locus_tag="BSU03630" /label="ubiX gene" promotor_-35 complement(394119..394126) /Source="Nicolas_upshift_promotors" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="promotor_-35" CDS 394724..396145 /gene="bsdC" /locus_tag="BSU_03640" /old_locus_tag="BSU03640" /EC_number="4.1.1.61" /EC_number="4.1.1.-" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11029449, 15979273, 17295427, 18388975, 26658822, 26337367; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phenolic acid decarboxylase subunit;1,4-dihydroxy-2-naphtoate-heptaprenyl diphosphatedecarboxylase" /protein_id="NP_388246.1" /db_xref="EnsemblGenomes-Gn:BSU03640" /db_xref="EnsemblGenomes-Tr:CAB12158" /db_xref="GOA:P94405" /db_xref="InterPro:IPR002830" /db_xref="InterPro:IPR012349" /db_xref="InterPro:IPR032902" /db_xref="SubtiList:BG12024" /db_xref="UniProtKB/Swiss-Prot:P94405" /translation="MAYQDFREFLAALEKEGQLLTVNEEVKPEPDLGASARAASNLGD KSPALLFNNIYGYHNARIAMNVIGSWPNHAMMLGMPKDTPVKEQFFEFAKRYDQFPMP VKREETAPFHENEITEDINLFDILPLFRINQGDGGYYLDKACVISRDLEDPDNFGKQN VGIYRMQVKGKDRLGIQPVPQHDIAIHLRQAEERGINLPVTIALGCEPVITTAASTPL LYDQSEYEMAGAIQGEPYRIVKSKLSDLDVPWGAEVVLEGEIIAGEREYEGPFGEFTG HYSGGRSMPIIKIKRVYHRNNPIFEHLYLGMPWTECDYMIGINTCVPLYQQLKEAYPN EIVAVNAMYTHGLIAIVSTKTRYGGFAKAVGMRALTTPHGLGYCKMVIVVDEDVDPFN LPQVMWALSTKMHPKHDAVIIPDLSVLPLDPGSNPSGITHKMILDATTPVAPETRGHY SQPLDSPLTTKEWEQKLMDLMNK*" /label="bsdC CDS" gene 394724..396145 /gene="bsdC" /locus_tag="BSU_03640" /old_locus_tag="BSU03640" /label="bsdC gene" CDS 396162..396389 /gene="bsdD" /locus_tag="BSU_03651" /old_locus_tag="BSU03651" /EC_number="4.1.1.91" /EC_number="4.1.1.-" /EC_number="4.1.1.61" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15979273, 17295427, 18388975, 26658822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase subunit" /protein_id="YP_003097675.1" /db_xref="EnsemblGenomes-Gn:BSU03651" /db_xref="EnsemblGenomes-Tr:CAX52546" /db_xref="GOA:C0H3U9" /db_xref="UniProtKB/Swiss-Prot:C0H3U9" /translation="MHTCPRCDSKKGEVMSKSPVEGAWEVYQCQTCFFTWRSCEPESI TNPEKYNPAFKIDPKETETAIEVPAVPERKA*" /label="bsdD CDS" gene 396162..396389 /gene="bsdD" /locus_tag="BSU_03651" /old_locus_tag="BSU03651" /label="bsdD gene" CDS 396386..396850 /gene="yclD" /locus_tag="BSU_03652" /old_locus_tag="BSU03652" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15979273, 18388975; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FMN-binding enzyme subunit" /protein_id="NP_388247.2" /db_xref="EnsemblGenomes-Gn:BSU03652" /db_xref="EnsemblGenomes-Tr:CAB12159" /db_xref="GOA:C0SPB5" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12025" /db_xref="UniProtKB/Swiss-Prot:C0SPB5" /translation="MIRVNCMSDRLFELLDGSCLNEKQHEAFVLQTVSEDGWPHAAMI SAGEIIALSRTDIRIALWKNTMTSANILRTGKAQFTAWWKGAAYYVKLECAPLPPLKD AEYERDRFSCRIVSVKEDVAKYADLTSGVRIQLHSPEEVLSRWKKTLEDLKR*" /label="yclD CDS" gene 396386..396850 /gene="yclD" /locus_tag="BSU_03652" /old_locus_tag="BSU03652" /label="yclD gene" downshifts 396831 /Source="Nicolas_upshifts" /id="D158" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="3.32586" /MaxDrop="3.88166" /score="45.8937489" /energy="-15.1" /TU="NA" /idTUdmin="U278" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 396857..396858 /Source="Nicolas_upshift_promotors" /id="U279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.357642357642358" /psig="0.557442557442557" /xcortree=3132 /SigmaFactorBS="ctgaagaggtgctgagcagatggaaaaagaccctggaagatt taaaacggtaatatcgaTAgcctgacgccatgcgtcaggctttttttatataatgaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 396858 /Source="Nicolas_upshifts" /id="U279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.357642357642358" /psig="0.557442557442557" /xcortree=3132 /SigmaFactorBS="ctgaagaggtgctgagcagatggaaaaagaccctggaagatt taaaacggtaatatcgaTAgcctgacgccatgcgtcaggctttttttatataatgaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 396917..397762 /gene="yclE" /locus_tag="BSU_03660" /old_locus_tag="BSU03660" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388248.2" /db_xref="EnsemblGenomes-Gn:BSU03660" /db_xref="EnsemblGenomes-Tr:CAB12160" /db_xref="GOA:P94407" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12026" /db_xref="UniProtKB/Swiss-Prot:P94407" /translation="MERAGICHSDGFDLAYRIEGEGAPILVIGSAVYYPRLFSSDIKQ KYQWVFVDHRGFAKPKRELRAEDSRLDAVLADIERMRTFLQLEDVTILGHSGHAFMAL EYARTYPKQVRKVALFNTAPDNSEERQRKSESFFMETASLERKKRFEKDIENLPQDID KDPERRFVHMCIRAEAKSFYQERPHAAALWDGVFTNMPIIDELWGNTFARIDLLQRLA DVRMPVYIGLGRYDYLVAPVSLWDAVDGLYPHVDKVIFEKSGHQPMLEEPEAFDQSFR KWLDQ*" /label="yclE CDS" gene 396917..397762 /gene="yclE" /locus_tag="BSU_03660" /old_locus_tag="BSU03660" /label="yclE gene" CDS complement(397802..399280) /gene="dtpT" /locus_tag="BSU_03670" /old_locus_tag="BSU03670" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8458848, 11717292, 15849754, 16204487, 16850406, 17496096, 23144141, 25966844; Product type t: transporter" /codon_start=1 /transl_table=11 /product="di-tripeptide-proton ABC symporter" /protein_id="NP_388249.2" /db_xref="EnsemblGenomes-Gn:BSU03670" /db_xref="EnsemblGenomes-Tr:CAB12175" /db_xref="GOA:P94408" /db_xref="InterPro:IPR000109" /db_xref="InterPro:IPR005279" /db_xref="InterPro:IPR018456" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12027" /db_xref="UniProtKB/Swiss-Prot:P94408" /translation="MASIDNESIIKSVPQKGFFGHPRGLFTLFFTEFWERFSYYGMRA ILLYYLYTETVNGGLGFDKGTAVAIMSIYGSLVYMSTIIGGWLADRVFGTANTVFYGG IFIMFGHIALAYPGSSIAFYISMVLIIVGTGLLKPNVSSVVGDLYTKEDPRRDSGFSI FYMGINLGGLLAPLIVGTLGQKYNYHLGFGAAAVGMLLGLIVFALTRKKNLGLAGSNV PNPLSKKSAIGTGIGVIIVAIAVIISVQTGVLTIKRFIDLVSILGILIPVIYFIIMFT SKKADKTEKSRLAAYVPLFIGAVMFWAIQEQGATILAVYADERIRLSLGGFELQSSWF QSLNPLFVVIFAPIFAWLWMKLGKRQPSTPVKFSIGIILAGLSFIIMVFPAMQGKEAL VSPLWLVLSFLLVVLGELCLSPVGLSVTTKLAPAAFSAQTMSMWFLTNAAAQAINAQV AGLFDKIPETMYFGTIGLISIVLGGILLLLSPVIKRAMKGVL*" /label="dtpT CDS" gene complement(397802..399280) /gene="dtpT" /locus_tag="BSU_03670" /old_locus_tag="BSU03670" /label="dtpT gene" downshifts complement(397810) /Source="Nicolas_upshifts" /id="D159" /incds=0 /nref=17 /ntot=90 /MaxReadThrough="1.40624" /MaxDrop="3.91827" /score="43.5753464" /energy="-21" /TU="NA" /idTUdmin="U281" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 399307..399309 /Source="Nicolas_upshift_promotors" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(399308..399327) /Source="Nicolas_upshift_promotors" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 399318 /Source="Nicolas_upshifts" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 399326..399344 /Source="Nicolas_upshift_promotors" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(399328) /Source="Nicolas_upshifts" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(399330..399834) /Source="Nicolas_S_feature" /locus_tag="new_417763_418267_c" /HighExp="S3, S4, LoTm, S5, S6, T5.0H, T4.0H, M9-stat, S8, T3.30H" /AntisenseName="yclG" /AntisenseCor="0.33937447534762299" /AntisenseRegPval="-7.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S128" promotor_-35 complement(399342..399349) /Source="Nicolas_upshift_promotors" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 399498..399507 /Source="Nicolas_upshift_promotors" /id="U282" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1425 /SigmaFactorBS="attcctttatatttttttaataaaattttagagaaatGTACA AGCAGatcgggcctttgTGAGTAACATGATAGTAATCatagagaaggaggctcgcaat t" /listShort="yclG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 399520..399539 /Source="Nicolas_upshift_promotors" /id="U282" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1425 /SigmaFactorBS="attcctttatatttttttaataaaattttagagaaatGTACA AGCAGatcgggcctttgTGAGTAACATGATAGTAATCatagagaaggaggctcgcaat t" /listShort="yclG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 399521 /Source="Nicolas_upshifts" /id="U282" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1425 /SigmaFactorBS="attcctttatatttttttaataaaattttagagaaatGTACA AGCAGatcgggcctttgTGAGTAACATGATAGTAATCatagagaaggaggctcgcaat t" /listShort="yclG" /GFF_Attribute="listLong" /label="upshifts" CDS 399560..401314 /gene="yclG" /locus_tag="BSU_03680" /old_locus_tag="BSU03680" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative uronase" /protein_id="NP_388250.1" /db_xref="EnsemblGenomes-Gn:BSU03680" /db_xref="EnsemblGenomes-Tr:CAB12176" /db_xref="InterPro:IPR006626" /db_xref="InterPro:IPR006633" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="InterPro:IPR024535" /db_xref="SubtiList:BG12028" /db_xref="UniProtKB/Swiss-Prot:P94409" /translation="MAEFILNAADFGVPRDGKTDSTERINQCLSTAVSKGYHTVWFPK GTYLIDATLGGDLNQRFRNAGIIVPGNLEIMMDPECIMKVIPNSSWGYSAFYVGKQEN ITISGGQIIGERDEHTYASAGIRSTHEWGFGICIEGCSNVVIDDVKISDFTGDGIIVS PRGLKTNQDYRTSEQIIIRRCEVRRSRRNNISITGCDMVTVEECLIEDAGTGNGTAPK FGIDIEGYGEGDVDYEEPINVSIRNNHFVGNVSSSVTNFNGYGILIEGNHSDNTISYG YGTQTVIKGNILRRPEDAAAAPRVGITGLGVSQGKETSDAVIAGNLITGFSTGIDVRG KSVLVTNNKISNFENTGILVYQSSDVKVDGNQIQNGLSETRRSIGLRAVLSDDIAFLN NCLIQVVDGVNVSGGNMIIKDNLLRKFSRGIWIAQGNAVIEGNTLNPDAFEAVPESYS VSVTNNAGAIIKNNTFKEFKNYPIYCSTSAKTSIIGNHLERSPLLVTIYISAGVHEIF DNTISVNRTAGNPIVIYLNGSAGSIISGNTINNLSAGTATAIQTNTSTNSKIIGNRIF KGTINKHSSDTIDGNMIV*" /label="yclG CDS" gene 399560..401314 /gene="yclG" /locus_tag="BSU_03680" /old_locus_tag="BSU03680" /label="yclG gene" promotor_-10 complement(399831..399849) /Source="Nicolas_upshift_promotors" /id="U283" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1003 /SigmaFactorBS="atcccgttcgccgataatttgtcctccggaaataGTTATAtt ctcttgcttgcctACATAAAATGCGGAATAACcccacgaactattcggtatcactttc a" /listShort="S128, dtpT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(399844) /Source="Nicolas_upshifts" /id="U283" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1003 /SigmaFactorBS="atcccgttcgccgataatttgtcctccggaaataGTTATAtt ctcttgcttgcctACATAAAATGCGGAATAACcccacgaactattcggtatcactttc a" /listShort="S128, dtpT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(399865..399870) /Source="Nicolas_upshift_promotors" /id="U283" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1003 /SigmaFactorBS="atcccgttcgccgataatttgtcctccggaaataGTTATAtt ctcttgcttgcctACATAAAATGCGGAATAACcccacgaactattcggtatcactttc a" /listShort="S128, dtpT" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 401305 /Source="Nicolas_upshifts" /id="D160" /incds=0 /nref=6 /ntot=21 /MaxReadThrough="0.325519999999999" /MaxDrop="4.9689" /score="4.29139266" /energy="-5.4" /TU="NA" /idTUdmin="U282" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(401330..401551) /gene="yczF" /locus_tag="BSU_03690" /old_locus_tag="BSU03690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388251.1" /db_xref="EnsemblGenomes-Gn:BSU03690" /db_xref="EnsemblGenomes-Tr:CAB12177" /db_xref="GOA:O31479" /db_xref="SubtiList:BG12780" /db_xref="UniProtKB/Swiss-Prot:O31479" /translation="MKILGVTGFILICLLAISVLMDMLQGFSLTKAVYNNMSSFKMTT FAEWVVLLFFVLVLVREMYVIYKSKKKNP*" /label="yczF CDS" gene complement(401330..401551) /gene="yczF" /locus_tag="BSU_03690" /old_locus_tag="BSU03690" /label="yczF gene" promotor_-10 complement(401570..401581) /Source="Nicolas_upshift_promotors" /id="U284" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=857 /SigmaFactorBS="aaattgagattatgcattagggttagatgcGGTATAActtct ccgccaaagATAGACACTAAAagcggaggatgatgaagcatgaagatattgggcgtga c" /listShort="yczF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(401572) /Source="Nicolas_upshifts" /id="U284" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=857 /SigmaFactorBS="aaattgagattatgcattagggttagatgcGGTATAActtct ccgccaaagATAGACACTAAAagcggaggatgatgaagcatgaagatattgggcgtga c" /listShort="yczF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(401596..401602) /Source="Nicolas_upshift_promotors" /id="U284" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=857 /SigmaFactorBS="aaattgagattatgcattagggttagatgcGGTATAActtct ccgccaaagATAGACACTAAAagcggaggatgatgaagcatgaagatattgggcgtga c" /listShort="yczF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 401617..401623 /Source="Nicolas_upshift_promotors" /id="U285" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=903 /SigmaFactorBS="gagaagttataccgcatctaaccctaaTGCATAAtctcaatt ttaaaAGGAAGAATATGagaaaacgacaaggaaaggtatttgtgtatgcctttatttt c" /listShort="gerKA, gerKC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 401637..401648 /Source="Nicolas_upshift_promotors" /id="U285" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=903 /SigmaFactorBS="gagaagttataccgcatctaaccctaaTGCATAAtctcaatt ttaaaAGGAAGAATATGagaaaacgacaaggaaaggtatttgtgtatgcctttatttt c" /listShort="gerKA, gerKC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 401650 /Source="Nicolas_upshifts" /id="U285" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=903 /SigmaFactorBS="gagaagttataccgcatctaaccctaaTGCATAAtctcaatt ttaaaAGGAAGAATATGagaaaacgacaaggaaaggtatttgtgtatgcctttatttt c" /listShort="gerKA, gerKC" /GFF_Attribute="listLong" /label="upshifts" CDS 401677..403311 /gene="gerKA" /locus_tag="BSU_03700" /old_locus_tag="BSU03700" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10762253, 16707705, 16740944" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10762253, 16707705, 16740944; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_388252.1" /db_xref="EnsemblGenomes-Gn:BSU03700" /db_xref="EnsemblGenomes-Tr:CAB12178" /db_xref="GOA:P49939" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG11392" /db_xref="UniProtKB/Swiss-Prot:P49939" /translation="MPLFSKRKNNTDSKDKQNTDERNQEQQQEKERPVLISPSLAKNI AETKKEVGSSSDVIIREIKIGEQDHVHLAVIYISGLVDNNTIHESLIDPLVQDESIQN THAIQQILEKTLPLGGVKAEKSWDKLFSELMLGNALIFADGHDEALICSTQGGEQRSI QEPSTQVSFRGPRQGFTESLQTNISMIRRYIKNPNLWVEKMKKGSVTNTDIALMYIQG ICDEKVLKEVKQRLEKIDIDSILESGYIEQLIEDETFTTFPTMYHTERPDVVAGNLLE GRFAIIVDGTPFVLIAPALFVQFFQSVEDYYSRFDIATSIRILRVLVFFISLVAPAVY VAATTFHQEMIPTQLLVVIAAQREIVPFPAVVEALTMEVAFEILREAGVRLPRVVGSA VSIVGALVIGQAAVQAGIVSPAMVIIVALTAIASFATPAFAMAISARLIRFIFIIASA VMGFYGLILGIIMMFVHLCSLRSFGVPYMSPLAPFSSQGVKDALFRVPWWADEKRPES VSKEDKVRQGKDQRPEPAASRGMVNKDLEEGDQNGT*" /label="gerKA CDS" gene 401677..403311 /gene="gerKA" /locus_tag="BSU_03700" /old_locus_tag="BSU03700" /label="gerKA gene" CDS 403301..404524 /gene="gerKC" /locus_tag="BSU_03710" /old_locus_tag="BSU03710" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10762253, 16707705, 16740944, 19363077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10762253, 16707705, 16740944, 19363077; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_388253.1" /db_xref="EnsemblGenomes-Gn:BSU03710" /db_xref="EnsemblGenomes-Tr:CAB12179" /db_xref="GOA:P49941" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG11394" /db_xref="UniProtKB/Swiss-Prot:P49941" /translation="MVRKCLLAVLMLLSVIVLPGCWDKRELTDLAIISAIGIDRTNDS NYVLHLQIINPGNVAGGLQGGGAGDRPPVSVYSIEGNNITEALRKASMKVSRRLYFAH TNLVVINEKLAKEEGLDFVLDNLDRDTEFRTTATFVVAHKTKAENIVKILTPIDKIPS NKVNKTLDFTEAQYGRVVKINIQDVLKTLAANTMAPVIPGYMMIGDDKKGVSMENTQA TDPKAILQADGLAVFDKAGYLKYWLEDDESVGAVWLMNKIQHTFINADWGKTKDAVSL QVTHQDTKLVPKMRNGRPYIHVKVSVEGIIDAVKYPFQLSDPKVLAAIEKALNKELEK EISHTVKKIKKNKIDFIGFGDTIYRKYPEQWEKMKDTWDKEYLPELPIDVKAETYIRR TGLRNNPIKHQFKDD*" /label="gerKC CDS" gene 403301..404524 /gene="gerKC" /locus_tag="BSU_03710" /old_locus_tag="BSU03710" /label="gerKC gene" CDS 404549..405670 /gene="gerKB" /locus_tag="BSU_03720" /old_locus_tag="BSU03720" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10762253, 15849754, 16707705, 16740944, 16850406, 19363077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10762253, 15849754, 16707705, 16740944, 16850406, 19363077; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_388254.1" /db_xref="EnsemblGenomes-Gn:BSU03720" /db_xref="EnsemblGenomes-Tr:CAB12180" /db_xref="GOA:P49940" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG11393" /db_xref="UniProtKB/Swiss-Prot:P49940" /translation="MEKARISIRQLFVMIIIFELGSSLLITPGSMAGRDAWIAVLLGC AIGLFLFYLYQGIYQCYPNSSPKEYMDDMLGTKLSWLFSFLYILYFAYIAARVLRDFG EMLLTFAYHDTPIIIVNALLMVVSIYAVRKGIEVLARAAELLFGAMYLLGAIGLVLII VSGTIDPHNLKPVLANGISPVLHSVFTQTMYVPFGEVVLFVMIFPNLNDRKDVKKMGM IAMAISGLIVALTVAINISVLDVDLTLRSQFPLLSTIQTIKVEEFLDRLDVFFMLALI IGGFFKVSLYLYATVVGTSTLFKEKNPSQLAYPMGLGILILSITIATNFSEHLNEGLN VVPLYIHLPFQLLFPLFLFIVAVWKKKRREKSKGEEAKK*" /label="gerKB CDS" gene 404549..405670 /gene="gerKB" /locus_tag="BSU_03720" /old_locus_tag="BSU03720" /label="gerKB gene" downshifts 405654 /Source="Nicolas_upshifts" /id="D161" /incds=0 /nref=6 /ntot=58 /MaxReadThrough="2.55658" /MaxDrop="3.73002" /score="3.39927899" /energy="-10.5" /TU="NA" /idTUdmin="U285" /TUdmin=2200 /isTUend="FALSE" /label="downshifts" CDS complement(405775..406455) /gene="yclH" /locus_tag="BSU_03730" /old_locus_tag="BSU03730" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATPase component)" /protein_id="NP_388255.1" /db_xref="EnsemblGenomes-Gn:BSU03730" /db_xref="EnsemblGenomes-Tr:CAB12181" /db_xref="GOA:P94411" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12029" /db_xref="UniProtKB/Swiss-Prot:P94411" /translation="MSLLQFQQVGYWYKNKSQPLFQDINISFQKGKFYTIVGTSGTGK TTFLSLAGGLDAPKEGNILYDGKAVSKIGLTNFRNQYVSIVFQAYNLLPYMTALQNVT TAMEITGSKEKNKESYALDMLQKVGINEKQARQKVLTLSGGQQQRVSITRAFCCDTDL IVADEPTGNLDEDTSKEIVRLFQDLAHKEDKCVIMVTHDEQIAKVSDINIRLSRGSFT VKENVAVV*" /label="yclH CDS" gene complement(405775..406455) /gene="yclH" /locus_tag="BSU_03730" /old_locus_tag="BSU03730" /label="yclH gene" CDS complement(406471..407931) /gene="yclI" /locus_tag="BSU_03740" /old_locus_tag="BSU03740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_388256.2" /db_xref="EnsemblGenomes-Gn:BSU03740" /db_xref="EnsemblGenomes-Tr:CAB12182" /db_xref="GOA:P94412" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG12030" /db_xref="UniProtKB/Swiss-Prot:P94412" /translation="MNFIKRAFWNMKAKKGKTLLQLFVFTVICVFVLSGLAIQSAAQK SSELARQELGGSVTLQVDRQKQMEKQQDSGEKRSFESTPIKVSDANKLAALDHVKSYN YTTSASANAGNFDAIESSSSSDSSSSSSSSNAKNSQGGGQGGPQMVQADLSIEGVIST ALVDDFSDGDSKITDGRAITKSDVGKKVTVINETLAEENDLSVGDSITIESATDEDTT VKLKIVGIYKTTSSGDDQAQNFSFLNPYNKLYTPYTATAALKGDDYKNTIDSAVYYMD DAKNMDTFVKAAKKTSIDFDTYTLNTNDQLYQQMVGPIENVASFSKNVVYLVSVAGAV ILGLIVMMSIRERKYEMGVLMAIGEKRWKLIGQFLTEILIVAVIAIGLASVTGNLVAN QLGNQLLSQQISSSTDSTQTASGQMPGGGGGMGGKMFGHSSSNVDVIDSLNVAVSMND MLILGGIGILIAIIATLLPSISVLRLHPKTILTKQE*" /label="yclI CDS" gene complement(406471..407931) /gene="yclI" /locus_tag="BSU_03740" /old_locus_tag="BSU03740" /label="yclI gene" misc_feature 408101..408120 /Source="Nicolas_upshift_promotors" /id="U286" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.647352647352647" /psig="0.962037962037962" /xcortree=1584 /SigmaFactorBS="tctagttgatgaaataaaaactaacaattgtgaaacgcaaaa ccttctgtttaaaatGGTGCTATTATATAAAAAAGcatcaaaacaaccggaggatata a" /listShort="yclJ, yclK, S129, rapC, phrC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 408104 /Source="Nicolas_upshifts" /id="U286" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.647352647352647" /psig="0.962037962037962" /xcortree=1584 /SigmaFactorBS="tctagttgatgaaataaaaactaacaattgtgaaacgcaaaa ccttctgtttaaaatGGTGCTATTATATAAAAAAGcatcaaaacaaccggaggatata a" /listShort="yclJ, yclK, S129, rapC, phrC" /GFF_Attribute="listLong" /label="upshifts" CDS 408144..408827 /gene="yclJ" /locus_tag="BSU_03750" /old_locus_tag="BSU03750" /function="16.10: Respire" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15375128, 20512483" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15375128, 20512483; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YclK] (possibly involved in arabinogalactan metabolism)" /protein_id="NP_388257.1" /db_xref="EnsemblGenomes-Gn:BSU03750" /db_xref="EnsemblGenomes-Tr:CAB12183" /db_xref="GOA:P94413" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12031" /db_xref="UniProtKB/Swiss-Prot:P94413" /translation="MKILMIEDNVSVCTMTEMFFFKEGFEAEFVHDGLEGYQRFTEEN WDLIILDIMLPSMDGVTICRKIRETSTVPIIMLTAKDTESDQVIGFEMGADDYVTKPF SPLTLVARIKAVIRRYKATGKAVIDEDMIETECFTINKKTREVLLNGEPVENLTPKEF DLLYYLVQNPRQVFSREQLLEQVWGYQFYGDERTVDVHIKRLRKKLASEDKPFLYTVW GVGYKFDED*" /label="yclJ CDS" gene 408144..408827 /gene="yclJ" /locus_tag="BSU_03750" /old_locus_tag="BSU03750" /label="yclJ gene" CDS 408814..410235 /gene="yclK" /locus_tag="BSU_03760" /old_locus_tag="BSU03760" /function="16.3: Control" /function="16.10: Respire" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15375128, 20512483" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15375128, 20512483; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YclJ]" /protein_id="NP_388258.1" /db_xref="EnsemblGenomes-Gn:BSU03760" /db_xref="EnsemblGenomes-Tr:CAB12184" /db_xref="GOA:P94414" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12032" /db_xref="UniProtKB/Swiss-Prot:P94414" /translation="MMKIKYLYQLLLSHISILILAFVIIISLFSHFVKEFAYQNKVEE LTSYAVQIANEFQSGQVDMRRLYPYQDILSTRKTQFIIFNEEQQPYFLPEGFHHPPRE QLKKSEWNKLKKGQTVTIRADGRFDDEVSLVAQPIFVQNEFKGAVLLISPISGVEQMV NQVNLYMFYAVISTLVITILVSWLLSKFHVKRIQKLREATDKVASGDYDIHLENSYGD EIGVLASDFNIMAKKLKQSRDEIERLEKRRRQFIADVSHELKTPLTTINGLVEGLNSH TIPEDKKDKCFSLISEETKRMLRLVKENLDYEKIRSQQITLNKLDVPLIEVFEIVKEH LQQQAEEKQNKLMIQVEDHVIVHADYDRFIQILVNITKNSIQFTQNGDIWLRGMEGYK ETIIEIEDTGIGIPKEDIEHIWERFYKADISRTNTAYGEYGLGLSIVRQLVEMHQGTV EIKSEEGKGTKFIIRLPLTAKQQ*" /label="yclK CDS" gene 408814..410235 /gene="yclK" /locus_tag="BSU_03760" /old_locus_tag="BSU03760" /label="yclK gene" downshifts 410211 /Source="Nicolas_upshifts" /id="D162" /incds=0 /nref=20 /ntot=169 /MaxReadThrough="3.43905" /MaxDrop="4.91565" /score="13.4599201" /energy="-15" /TU="U286" /idTUdmin="U286" /TUdmin="-1427" /isTUend="FALSE" /label="downshifts" S_feature 410256..410360 /Source="Nicolas_S_feature" /locus_tag="new_428689_428793" /HighExp="Lbstat, nit, ferm, BI, M0t45, M40t45, M0t90, S0, S2, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.962" /TUlongSig="NA" /TUlongPSig="NA" /label="S129" misc_feature 410350..410369 /Source="Nicolas_upshift_promotors" /id="U287" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.986013986013986" /xcortree=678 /SigmaFactorBS="tcccgaaaacaaagattgcgtgtttttcgggttgggacggcc tataaaCATGATAAAATATGACATAAacagtttttgatgggagagggtgaaggaatga a" /listShort="rapC, phrC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 410362 /Source="Nicolas_upshifts" /id="U287" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.986013986013986" /xcortree=678 /SigmaFactorBS="tcccgaaaacaaagattgcgtgtttttcgggttgggacggcc tataaaCATGATAAAATATGACATAAacagtttttgatgggagagggtgaaggaatga a" /listShort="rapC, phrC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(410394) /Source="Nicolas_upshifts" /id="D163" /incds=0 /nref=2 /ntot=81 /MaxReadThrough="1.74985" /MaxDrop="4.10695" /score="1.47729412" /energy="-10.3" /TU="NA" /idTUdmin="U290" /TUdmin=1320 /isTUend="FALSE" /label="downshifts" CDS 410398..411546 /gene="rapC" /locus_tag="BSU_03770" /old_locus_tag="BSU03770" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10464187, 12456319, 12897006, 12950917, 15968044, 19202088" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464187, 12456319, 12897006, 12950917, 15968044, 19202088; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_388259.1" /db_xref="EnsemblGenomes-Gn:BSU03770" /db_xref="EnsemblGenomes-Tr:CAB12185" /db_xref="GOA:P94415" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11966" /db_xref="UniProtKB/Swiss-Prot:P94415" /translation="MKSGVIPSSAVGQKINEWYRYIRTFSVPDAEVLKAEIQQELKHM QHDSNLLLYYSLMEFRHQLMLDYLEPLEKLNIEDQPSLSELSRNIDSNQADLKGLLDY YVNFFRGMYEFDKREFISAITYYKQAEKKLSFVADHIERAEFYFKIAEAYYYMKQTYF SLINIKNAYEIYVEQETYNVRIIQCHFVFGVNLMDERNFEQAARHFKLALNMAQAEQK AQLVGRAYYNLGLCYYNQDLLDPAIDYFEKAVSTFESSRIVNSLPQAYFLITLIYYKQ GKHDKASEYHKRGYEYAKETDDADYAVKFEFLQSLYLDQPNEEGIERCFQYLKNKNMY ADIEDLALEVAKYYYEQKWFKLSASYFLQVEEARKQIQRSEGLYEIEI*" /label="rapC CDS" gene 410398..411546 /gene="rapC" /locus_tag="BSU_03770" /old_locus_tag="BSU03770" /label="rapC gene" promotor_-35 411246..411251 /Source="Nicolas_upshift_promotors" /id="U288" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=1063 /SigmaFactorBS="caccctgatttattataaacagggaaaacatgataaagcttc GGAATAtcacaagcggggctatGAATATGCTAAAGAAACAGacgatgcagactatgcc g" /listShort="phrC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 411264 /Source="Nicolas_upshifts" /id="U288" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=1063 /SigmaFactorBS="caccctgatttattataaacagggaaaacatgataaagcttc GGAATAtcacaagcggggctatGAATATGCTAAAGAAACAGacgatgcagactatgcc g" /listShort="phrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 411268..411286 /Source="Nicolas_upshift_promotors" /id="U288" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=1063 /SigmaFactorBS="caccctgatttattataaacagggaaaacatgataaagcttc GGAATAtcacaagcggggctatGAATATGCTAAAGAAACAGacgatgcagactatgcc g" /listShort="phrC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 411408..411416 /Source="Nicolas_upshift_promotors" /id="U289" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.753246753246753" /psig="0.753246753246753" /xcortree=788 /SigmaFactorBS="taaaaaataaaaatatgtacgctgatatAGAGGATTTagccc tagaagTAGCAAAATATTACTATGAacagaaatggtttaaactgtctgcttcctactt t" /listShort="phrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 411428..411446 /Source="Nicolas_upshift_promotors" /id="U289" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.753246753246753" /psig="0.753246753246753" /xcortree=788 /SigmaFactorBS="taaaaaataaaaatatgtacgctgatatAGAGGATTTagccc tagaagTAGCAAAATATTACTATGAacagaaatggtttaaactgtctgcttcctactt t" /listShort="phrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 411440 /Source="Nicolas_upshifts" /id="U289" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.753246753246753" /psig="0.753246753246753" /xcortree=788 /SigmaFactorBS="taaaaaataaaaatatgtacgctgatatAGAGGATTTagccc tagaagTAGCAAAATATTACTATGAacagaaatggtttaaactgtctgcttcctactt t" /listShort="phrC" /GFF_Attribute="listLong" /label="upshifts" CDS 411530..411652 /gene="phrC" /locus_tag="BSU_03780" /old_locus_tag="BSU03780" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10464187, 12456319, 12897006, 12950917, 16816200, 19202088" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464187, 12456319, 12897006, 12950917, 16816200, 19202088; Product type r : regulator" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapC and competence and sporulation stimulating factor (CSF)" /protein_id="NP_388260.1" /db_xref="EnsemblGenomes-Gn:BSU03780" /db_xref="EnsemblGenomes-Tr:CAB12186" /db_xref="GOA:P94416" /db_xref="InterPro:IPR020243" /db_xref="InterPro:IPR025899" /db_xref="SubtiList:BG11959" /db_xref="UniProtKB/Swiss-Prot:P94416" /translation="MKLKSKLFVICLAAAAIFTAAGVSANAEALDFHVTERGMT*" /label="phrC CDS" gene 411530..411652 /gene="phrC" /locus_tag="BSU_03780" /old_locus_tag="BSU03780" /label="phrC gene" downshifts 411639 /Source="Nicolas_upshifts" /id="D164" /incds=0 /nref=260 /ntot=275 /MaxReadThrough="3.24518" /MaxDrop="7.70367" /score="26.3182765" /energy="-14" /TU="NA" /idTUdmin="U286" /TUdmin=1 /isTUend="TRUE" /label="downshifts" downshifts complement(411707) /Source="Nicolas_upshifts" /id="D165" /incds=0 /nref=3 /ntot=64 /MaxReadThrough="0.60499" /MaxDrop="7.4475" /score="-1.25354129" /energy="-15.8" /TU="NA" /idTUdmin="U290" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(411752..411841) /gene="yczM" /locus_tag="BSU_03788" /old_locus_tag="BSU03788" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative type I toxin" /protein_id="YP_003097676.1" /db_xref="EnsemblGenomes-Gn:BSU03788" /db_xref="EnsemblGenomes-Tr:CAX52547" /db_xref="GOA:C0H3V0" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3V0" /translation="MSGYGTSFALIVVLFILLIIVGTAFVGGY*" /label="yczM CDS" gene complement(411752..411841) /gene="yczM" /locus_tag="BSU_03788" /old_locus_tag="BSU03788" /label="yczM gene" downshifts complement(411912) /Source="Nicolas_upshifts" /id="D166" /incds=0 /nref=25 /ntot=113 /MaxReadThrough="7.05273" /MaxDrop="3.3619" /score="32.1465401" /energy="-16.5" /TU="U290" /idTUdmin="U290" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" CDS complement(411923..412036) /gene="yczN" /locus_tag="BSU_03789" /old_locus_tag="BSU03789" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore and germination protein" /protein_id="YP_003097677.1" /db_xref="EnsemblGenomes-Gn:BSU03789" /db_xref="EnsemblGenomes-Tr:CAX52548" /db_xref="GOA:C0H3V1" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3V1" /translation="MSGYSNGGGYGGISSFALIVVLFILLIIVGTAFVGGF*" /label="yczN CDS" gene complement(411923..412036) /gene="yczN" /locus_tag="BSU_03789" /old_locus_tag="BSU03789" /label="yczN gene" promotor_-10 complement(412057..412076) /Source="Nicolas_upshift_promotors" /id="U290" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1406 /SigmaFactorBS="attcttcattttttctcttgtccactattaTCCCTGCCAAat ggatcggttcAGCATATCTTATAGTATCCTtcatagggaggtgaaaccttatgtcagg a" /listShort="yczN, yczM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(412068) /Source="Nicolas_upshifts" /id="U290" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1406 /SigmaFactorBS="attcttcattttttctcttgtccactattaTCCCTGCCAAat ggatcggttcAGCATATCTTATAGTATCCTtcatagggaggtgaaaccttatgtcagg a" /listShort="yczN, yczM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(412089..412098) /Source="Nicolas_upshift_promotors" /id="U290" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1406 /SigmaFactorBS="attcttcattttttctcttgtccactattaTCCCTGCCAAat ggatcggttcAGCATATCTTATAGTATCCTtcatagggaggtgaaaccttatgtcagg a" /listShort="yczN, yczM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(412190..413554) /gene="thrD" /locus_tag="BSU_03790" /old_locus_tag="BSU03790" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2152900, 11471740, 27260660" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2152900, 11471740, 27260660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate kinase III" /protein_id="NP_388261.1" /db_xref="EnsemblGenomes-Gn:BSU03790" /db_xref="EnsemblGenomes-Tr:CAB12187" /db_xref="GOA:P94417" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001341" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005260" /db_xref="InterPro:IPR018042" /db_xref="InterPro:IPR027795" /db_xref="InterPro:IPR035804" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG12033" /db_xref="UniProtKB/Swiss-Prot:P94417" /translation="MKVVKFGGSSLASGAQLDKVFHIVTSDPARKAVVVSAPGKHYAE DTKVTDLLIACAEQYLATGSAPELAEAVVERYALIANELQLGQSIIEKIRDDLFTLLE GDKSNPEQYLDAVKASGEDNNAKLIAAYFRYKGVKAEYVNPKDAGLFVTNEPGNAQVL PESYQNLYRLRERDGLIIFPGFFGFSKDGDVITFSRSGSDITGSILANGLQADLYENF TDVDAVYSVNPSFVENPKEISELTYREMRELSYAGFSVFHDEALIPAFRAGIPVQIKN TNNPSAEGTRVVSKRDNTNGPVVGIASDTGFCSIYISKYLMNREIGFGRRALQILEEH GLTYEHVPSGIDDMTIILRQGQMDAATERSVIKRIEEDLHADEVIVEHHLALIMVVGE AMRHNVGTTARAAKALSEAQVNIEMINQGSSEVSMMFGVKEAEERKAVQALYQEFFAG VLIS*" /label="thrD CDS" gene complement(412190..413554) /gene="thrD" /locus_tag="BSU_03790" /old_locus_tag="BSU03790" /label="thrD gene" downshifts complement(412198) /Source="Nicolas_upshifts" /id="D167" /incds=0 /nref=23 /ntot=129 /MaxReadThrough="2.21842" /MaxDrop="4.81019" /score="44.9085917" /energy="-15" /TU="NA" /idTUdmin="U291" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(412242) /Source="Nicolas_upshifts" /id="D168" /incds=0 /nref=1 /ntot=17 /MaxReadThrough="5.53807" /MaxDrop="2.54279" /score="44.9085917" /energy="-15" /TU="U291" /idTUdmin="U291" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(413590..413609) /Source="Nicolas_upshift_promotors" /id="U291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.946053946053946" /psig="0.999000999001" /xcortree=3042 /SigmaFactorBS="aaaaatacaaatgttctcctgagaaagaaattcccCCTTGAT TtacagtactgaaagAGAGATAATAAATACTAAATttgtgtgaaaattttaaacatta g" /listShort="yclM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(413606) /Source="Nicolas_upshifts" /id="U291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.946053946053946" /psig="0.999000999001" /xcortree=3042 /SigmaFactorBS="aaaaatacaaatgttctcctgagaaagaaattcccCCTTGAT TtacagtactgaaagAGAGATAATAAATACTAAATttgtgtgaaaattttaaacatta g" /listShort="yclM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(413624..413631) /Source="Nicolas_upshift_promotors" /id="U291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.946053946053946" /psig="0.999000999001" /xcortree=3042 /SigmaFactorBS="aaaaatacaaatgttctcctgagaaagaaattcccCCTTGAT TtacagtactgaaagAGAGATAATAAATACTAAATttgtgtgaaaattttaaacatta g" /listShort="yclM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 413745..413749 /Source="Nicolas_upshift_promotors" /id="U292" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.843156843156843" /psig="0.997002997002997" /xcortree=2746 /SigmaFactorBS="aaatatggtaaacagcctaacgttttggGATGGaaaatggtt agaatgATTAGTAAAATTGATAAATGactaggttaatatttttaaagaatattgacta a" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 413765..413784 /Source="Nicolas_upshift_promotors" /id="U292" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.843156843156843" /psig="0.997002997002997" /xcortree=2746 /SigmaFactorBS="aaatatggtaaacagcctaacgttttggGATGGaaaatggtt agaatgATTAGTAAAATTGATAAATGactaggttaatatttttaaagaatattgacta a" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 413777 /Source="Nicolas_upshifts" /id="U292" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.843156843156843" /psig="0.997002997002997" /xcortree=2746 /SigmaFactorBS="aaatatggtaaacagcctaacgttttggGATGGaaaatggtt agaatgATTAGTAAAATTGATAAATGactaggttaatatttttaaagaatattgacta a" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 413808..413815 /Source="Nicolas_upshift_promotors" /id="U293" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2099 /SigmaFactorBS="ataaatgactaggttaatatttttaaagaaTATTGACTaacc ctataaaaaTGGTAATATGTAAATGATAAtgataatcaattactatatggccatattg t" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 413829..413848 /Source="Nicolas_upshift_promotors" /id="U293" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2099 /SigmaFactorBS="ataaatgactaggttaatatttttaaagaaTATTGACTaacc ctataaaaaTGGTAATATGTAAATGATAAtgataatcaattactatatggccatattg t" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 413838..413938 /Source="Nicolas_S_feature" /locus_tag="new_432271_432371" /HighExp="LBGexp, Lbexp, G150, dia0, G135, H2O2, Paraq, dia15, G180, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S130" upshifts 413838 /Source="Nicolas_upshifts" /id="U293" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2099 /SigmaFactorBS="ataaatgactaggttaatatttttaaagaaTATTGACTaacc ctataaaaaTGGTAATATGTAAATGATAAtgataatcaattactatatggccatattg t" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="upshifts" CDS 413939..414889 /gene="pbtN" /locus_tag="BSU_03800" /old_locus_tag="BSU03800" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16850406, 19955416" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16850406, 19955416; Product type t: transporter" /codon_start=1 /transl_table=11 /product="petrobactin iron-siderophore ABC transporter (permease)" /protein_id="NP_388262.1" /db_xref="EnsemblGenomes-Gn:BSU03800" /db_xref="EnsemblGenomes-Tr:CAB12188" /db_xref="GOA:P94418" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12034" /db_xref="UniProtKB/Swiss-Prot:P94418" /translation="MKLRYLFILLIILAVTSVFIGVEDLSPLDLFDLSKQEASTLFAS RLPRLISIVIAGLSMSICGLIMQQISRNKFVSPTTAGTMDWARLGILISLLLFTSASP LIKMLVAFVFALAGNFLFMKILERIKFNDTIFIPLVGLMLGNIVSSIATFIAYKYDLI QNVSSWLQGDFSLVVKGRYELLYLSIPLVIIAYVYADKFTLAGMGESFSVNLGLKYKR VVNIGLIIVSLITSLVILTVGMLPFLGLIIPNIVSIYRGDNLKSSLPHTVLLGAVFVL FCDILGRIIIFPYEISIGLMVGIIGSGIFLFMLLRRKAYA*" /label="pbtN CDS" gene 413939..414889 /gene="pbtN" /locus_tag="BSU_03800" /old_locus_tag="BSU03800" /label="pbtN gene" CDS 414882..415829 /gene="pbtO" /locus_tag="BSU_03810" /old_locus_tag="BSU03810" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16850406, 19955416" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16850406, 19955416; Product type t: transporter" /codon_start=1 /transl_table=11 /product="petrobactin iron-siderophore ABC transporter (permease)" /protein_id="NP_388263.1" /db_xref="EnsemblGenomes-Gn:BSU03810" /db_xref="EnsemblGenomes-Tr:CAB12189" /db_xref="GOA:P94419" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12035" /db_xref="UniProtKB/Swiss-Prot:P94419" /translation="MRNQMKIALLVGLAIVCIGLFLFYDLGNWDYTLPRRIKKVAAIV LTGGAIAFSTMIFQTITNNRILTPSILGLDSLYMLIQTGIIFLFGSANMVIMNKNINF IISVLLMILFSLVLYQIMFKGEGRNIFFLLLIGIVFGTLFSSLSSFMQMLIDPNEFQV VQDKMFASFNNINTDLLWLAFIIFLLTGVYVWRFTKFFDVLSLGREHAVNLGIDYDKV VKQMLIVVAILVSVSTALVGPIMFLGLLVVNLAREFLKTYKHSYLIAGSVFISIIALV GGQFVVEKVFTFSTTLSVIINFAGGIYFIYLLLKENKSW*" /label="pbtO CDS" gene 414882..415829 /gene="pbtO" /locus_tag="BSU_03810" /old_locus_tag="BSU03810" /label="pbtO gene" CDS 415823..416581 /gene="pbtP" /locus_tag="BSU_03820" /old_locus_tag="BSU03820" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 19955416" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 19955416; Product type t: transporter" /codon_start=1 /transl_table=11 /product="petrobactin iron-siderophore ABC transporter (ATP-binding protein)" /protein_id="NP_388264.1" /db_xref="EnsemblGenomes-Gn:BSU03820" /db_xref="EnsemblGenomes-Tr:CAB12190" /db_xref="GOA:P94420" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12036" /db_xref="UniProtKB/Swiss-Prot:P94420" /translation="MVEVRNVSKQYGGKVVLEETSVTIQKGKITSFIGPNGAGKSTLL SIMSRLIKKDSGEIYIDGQEIGACDSKELAKKMSILKQANQINIRLTIKDLVSFGRFP YSQGRLTEEDWVHINQALSYMKLEDIQDKYLDQLSGGQCQRAFIAMVIAQDTDYIFLD EPLNNLDMKHSVEIMKLLKRLVEELGKTIVIVIHDINFASVYSDYIVALKNGRIVKEG PPEEMIETSVLEEIYDMTIPIQTIDNQRIGVYFS*" /label="pbtP CDS" gene 415823..416581 /gene="pbtP" /locus_tag="BSU_03820" /old_locus_tag="BSU03820" /label="pbtP gene" CDS 416603..417556 /gene="pbtQ" /locus_tag="BSU_03830" /old_locus_tag="BSU03830" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 19955416, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 19955416, 25355936; Product type t: transporter" /codon_start=1 /transl_table=11 /product="petrobactin iron-siderophore ABC transporter (binding lipoprotein)" /protein_id="NP_388265.1" /db_xref="EnsemblGenomes-Gn:BSU03830" /db_xref="EnsemblGenomes-Tr:CAB12191" /db_xref="GOA:P94421" /db_xref="InterPro:IPR002491" /db_xref="InterPro:IPR033870" /db_xref="PDB:3GFV" /db_xref="SubtiList:BG12037" /db_xref="UniProtKB/Swiss-Prot:P94421" /translation="MKKFALLFIALVTAVVISACGNQSTSSKGSDTKKEQITVKHQLD KNGTKVPKNPKKVVVFDFGSLDTLDKLGLDDIVAGLPKQVLPKYLSKFKDDKYADVGS LKEPDFDKVAELDPDLIIISARQSESYKEFSKIAPTIYLGVDTAKYMESFKSDAETIG KIFDKEDKVKDELANIDHSIADVKKTAEKLNKNGLVIMANDGKISAFGPKSRYGLIHD VFGVAPADQNIKASTHGQSVSYEYISKTNPDYLFVIDRGTAIGETSSTKQVVENDYVK NVNAVKNGHVIYLDSATWYLSGGGLESMTQMIKEVKDGLEK*" /label="pbtQ CDS" gene 416603..417556 /gene="pbtQ" /locus_tag="BSU_03830" /old_locus_tag="BSU03830" /label="pbtQ gene" downshifts 417539 /Source="Nicolas_upshifts" /id="D169" /incds=0 /nref=161 /ntot=280 /MaxReadThrough="3.87669" /MaxDrop="7.4722" /score="31.9942335" /energy="-13.8" /TU="U293" /idTUdmin="U292" /TUdmin=5 /isTUend="TRUE" /label="downshifts" CDS complement(417603..419021) /gene="ycnB" /locus_tag="BSU_03840" /old_locus_tag="BSU03840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 15855514, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388266.1" /db_xref="EnsemblGenomes-Gn:BSU03840" /db_xref="EnsemblGenomes-Tr:CAB12192" /db_xref="GOA:P94422" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12038" /db_xref="UniProtKB/Swiss-Prot:P94422" /translation="MNTSIEQKPFNRSVIVGILLAGAFVAILNQTLLITALPHIMRDF NVDANQAQWLTTSFMLTNGILIPITAFLIEKFTSRALLITAMSIFTAGTVVGAFAPNF PVLLTARIIQAAGAGIMMPLMQTVFLTIFPIEKRGQAMGMVGLVISFAPAIGPTLSGW AVEAFSWRSLFYIILPFAVIDLILASILMKNVTTLRKTQIDILSVILSTFGFGGLLYG FSSVGSYGWSSSTVLISLLVGVIALLLFITRQMKLKKPMLEFRVFTFGVFSLTTLLGT LVFALLIGTETILPLYTQNVRDVTAFDTGLMLLPGAVVMGFMSPIIGRIFDRVGGRGL AIAGFCIIFLTSLPFMQLTDHTSLAWIVVLYTVRLLGTAMIMMPVTTAGINALPRHLI PHGTAMNNTIRQVGGSIGTALLVSVMSNQAAHAGTTNVKHAALHGMNAAFIVAAVIAL VGFLLSFTLKKPQRPAEQQPAR*" /label="ycnB CDS" gene complement(417603..419021) /gene="ycnB" /locus_tag="BSU_03840" /old_locus_tag="BSU03840" /label="ycnB gene" downshifts complement(417624) /Source="Nicolas_upshifts" /id="D170" /incds=0 /nref=8 /ntot=150 /MaxReadThrough="2.00954" /MaxDrop="5.13029" /score="17.5501827" /energy="-13.8" /TU="NA" /idTUdmin="U294" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(419041..419919) /gene="ycnC" /locus_tag="BSU_03850" /old_locus_tag="BSU03850" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388267.2" /db_xref="EnsemblGenomes-Gn:BSU03850" /db_xref="EnsemblGenomes-Tr:CAB12193" /db_xref="GOA:P94423" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG12039" /db_xref="UniProtKB/Swiss-Prot:P94423" /translation="MLDKKTDILLAARKLFSEKDFTSVSMQAIAEECKMSKASIYKLF QSKEDLLLELLSFNQKQMVAAASRLQENTALTPEERLTQKVKMELEGFRRNQQFFNML TYGNPKLHNDRVKQHIHQTRSTIICWHRDSLIQAYGETILPFVWDLVIILHGMMREFL MLIKIEEKPLELDPIAEFIISTLNQIIKNRETRQSLLPPEAIELYIHSASSYKPKDKS VLLSESLKELHKGISSLSAADYDVDELTSAAAMLEEEAKKEEPRAFLLKSLIGYLEQT GVLTQPVSMLKTLLIT*" /label="ycnC CDS" gene complement(419041..419919) /gene="ycnC" /locus_tag="BSU_03850" /old_locus_tag="BSU03850" /label="ycnC gene" S_feature complement(419920..419986) /Source="Nicolas_S_feature" /locus_tag="new_438353_438419_c" /HighExp="dia15, H2O2, Diami, Paraq, Oxctl, Cold, G180, Salt, BMM, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S131" promotor_-10 complement(419985..420004) /Source="Nicolas_upshift_promotors" /id="U294" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.373626373626374" /psig="0.999000999001" /xcortree=2489 /SigmaFactorBS="gcaggcctttcatttacccggttaaaatcCATTGACttctat tttgtttaTCTGGTAAAATTTTTTCATTgttactcattggttttctgtgaaccaatgg g" /listShort="S131, ycnC, ycnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(419994) /Source="Nicolas_upshifts" /id="U294" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.373626373626374" /psig="0.999000999001" /xcortree=2489 /SigmaFactorBS="gcaggcctttcatttacccggttaaaatcCATTGACttctat tttgtttaTCTGGTAAAATTTTTTCATTgttactcattggttttctgtgaaccaatgg g" /listShort="S131, ycnC, ycnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(420019..420025) /Source="Nicolas_upshift_promotors" /id="U294" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.373626373626374" /psig="0.999000999001" /xcortree=2489 /SigmaFactorBS="gcaggcctttcatttacccggttaaaatcCATTGACttctat tttgtttaTCTGGTAAAATTTTTTCATTgttactcattggttttctgtgaaccaatgg g" /listShort="S131, ycnC, ycnB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(420083..420832) /gene="nfrAB" /locus_tag="BSU_03860" /old_locus_tag="BSU03860" /EC_number="1.5.1.39" /EC_number="1.6.99.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16229462, 9836433, 20862523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16229462, 9836433, 20862523; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-FMN oxidoreductase (nitroreductase)" /protein_id="NP_388268.1" /db_xref="EnsemblGenomes-Gn:BSU03860" /db_xref="EnsemblGenomes-Tr:CAB12194" /db_xref="GOA:P94424" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR016446" /db_xref="InterPro:IPR029479" /db_xref="PDB:1ZCH" /db_xref="SubtiList:BG12040" /db_xref="UniProtKB/Swiss-Prot:P94424" /translation="MNEVIKSLTDHRSIRSYTDEPVAQEQLDQIIEAVQSAPSSINGQ QVTVITVQDKERKKKISELAGGQPWIDQAPVFLLFCADFNRAKIALEDLHDFKMEITN GLESVLVGAVDAGIALGTATAAAESLGLGTVPIGAVRGNPQELIELLELPKYVFPLSG LVIGHPADRSAKKPRLPQEAVNHQETYLNQDELTSHIQAYDEQMSEYMNKRTNGKETR NWSQSIASYYERLYYPHIREMLEKQGFKVEK*" /label="nfrAB CDS" gene complement(420083..420832) /gene="nfrAB" /locus_tag="BSU_03860" /old_locus_tag="BSU03860" /label="nfrAB gene" downshifts complement(420096) /Source="Nicolas_upshifts" /id="D171" /incds=0 /nref=136 /ntot=243 /MaxReadThrough="2.08639" /MaxDrop="5.10745" /score="11.1864402" /energy="-18.6" /TU="NA" /idTUdmin="U296" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(420849..421136) /gene="ycnE" /locus_tag="BSU_03870" /old_locus_tag="BSU03870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17274596, 21454635; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative AI-2 degrading enzyme" /protein_id="NP_388269.1" /db_xref="EnsemblGenomes-Gn:BSU03870" /db_xref="EnsemblGenomes-Tr:CAB12195" /db_xref="GOA:P94425" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="SubtiList:BG12041" /db_xref="UniProtKB/Swiss-Prot:P94425" /translation="MIVLQAYIKVKPEKREEFLSEAQSLVQHSRAEEGNAQYDLFEKV GEENTFVMLEKWKDEAAMKFHNETAHFQGFVAKGKELLSAPLDVVRTELSE*" /label="ycnE CDS" gene complement(420849..421136) /gene="ycnE" /locus_tag="BSU_03870" /old_locus_tag="BSU03870" /label="ycnE gene" promotor_-35 421102..421109 /Source="Nicolas_upshift_promotors" /id="U295" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.966033966033966" /psig="0.993006993006993" /xcortree=1982 /SigmaFactorBS="aaaattcctcgcgtttttctGGTTTTACtttgatgtaagctT GTAATACGATCATGTAAATctcctccgtcgttatgcgaatttattgttcgaatttcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 421123..421142 /Source="Nicolas_upshift_promotors" /id="U295" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.966033966033966" /psig="0.993006993006993" /xcortree=1982 /SigmaFactorBS="aaaattcctcgcgtttttctGGTTTTACtttgatgtaagctT GTAATACGATCATGTAAATctcctccgtcgttatgcgaatttattgttcgaatttcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 421142 /Source="Nicolas_upshifts" /id="U295" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.966033966033966" /psig="0.993006993006993" /xcortree=1982 /SigmaFactorBS="aaaattcctcgcgtttttctGGTTTTACtttgatgtaagctT GTAATACGATCATGTAAATctcctccgtcgttatgcgaatttattgttcgaatttcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(421180..421199) /Source="Nicolas_upshift_promotors" /id="U296" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=1945 /SigmaFactorBS="acaattagaatgacaattttactatataagggttttTCCTTT ACctcatttagaataCATGTTACATTTAGTTCGATgaaattcgaacaataaattcgca t" /listShort="ycnE, ycnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(421196) /Source="Nicolas_upshifts" /id="U296" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=1945 /SigmaFactorBS="acaattagaatgacaattttactatataagggttttTCCTTT ACctcatttagaataCATGTTACATTTAGTTCGATgaaattcgaacaataaattcgca t" /listShort="ycnE, ycnD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(421213..421220) /Source="Nicolas_upshift_promotors" /id="U296" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=1945 /SigmaFactorBS="acaattagaatgacaattttactatataagggttttTCCTTT ACctcatttagaataCATGTTACATTTAGTTCGATgaaattcgaacaataaattcgca t" /listShort="ycnE, ycnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 421241..421248 /Source="Nicolas_upshift_promotors" /id="U297" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.614385614385614" /psig="0.955044955044955" /xcortree=576 /SigmaFactorBS="taacatgtattctaaatgaggtaaaggaaaaacccttatata gtaaaaTTGTCATTctaattgttgTATGATACATTTGTGTCATGaacattccaaacca t" /listShort="yczG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 421253 /Source="Nicolas_upshifts" /id="U297" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.614385614385614" /psig="0.955044955044955" /xcortree=576 /SigmaFactorBS="taacatgtattctaaatgaggtaaaggaaaaacccttatata gtaaaaTTGTCATTctaattgttgTATGATACATTTGTGTCATGaacattccaaacca t" /listShort="yczG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 421259..421278 /Source="Nicolas_upshift_promotors" /id="U297" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.614385614385614" /psig="0.955044955044955" /xcortree=576 /SigmaFactorBS="taacatgtattctaaatgaggtaaaggaaaaacccttatata gtaaaaTTGTCATTctaattgttgTATGATACATTTGTGTCATGaacattccaaacca t" /listShort="yczG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 421276..421590 /gene="yczG" /locus_tag="BSU_03880" /old_locus_tag="BSU03880" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (ArsR family)" /protein_id="NP_388270.1" /db_xref="EnsemblGenomes-Gn:BSU03880" /db_xref="EnsemblGenomes-Tr:CAB12196" /db_xref="GOA:O31480" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12781" /db_xref="UniProtKB/Swiss-Prot:O31480" /translation="MNIPNHPETETLQLTKVLHALSDPLRLELVKQLAEAKEKTCSTC ADVQVAKSTLSHHFKVLRESGIAQVRIEGKRRYYSLRAEDLEKAFPGLLEAVLNVDQD RW*" /label="yczG CDS" gene 421276..421590 /gene="yczG" /locus_tag="BSU_03880" /old_locus_tag="BSU03880" /label="yczG gene" downshifts 421582 /Source="Nicolas_upshifts" /id="D172" /incds=0 /nref=173 /ntot=262 /MaxReadThrough="0.52252" /MaxDrop="5.32898" /score="20.7855667" /energy="-7.4" /TU="NA" /idTUdmin="U297" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(421592..423031) /gene="gabR" /locus_tag="BSU_03890" /old_locus_tag="BSU03890" /experiment="publication(s) with functional evidences, PMID:15223311, 24127574, 25388514, 27640111, 28348215, 28412355" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15223311, 24127574, 25388514, 27640111, 28348215, 28412355; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR/MocR family) with PLP binding site (GabR-GABA-PLP aldimine)" /protein_id="NP_388271.1" /db_xref="EnsemblGenomes-Gn:BSU03890" /db_xref="EnsemblGenomes-Tr:CAB12197" /db_xref="GOA:P94426" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:4MGR" /db_xref="PDB:4N0B" /db_xref="PDB:4TV7" /db_xref="PDB:5T4J" /db_xref="PDB:5T4K" /db_xref="PDB:5X03" /db_xref="SubtiList:BG12042" /db_xref="UniProtKB/Swiss-Prot:P94426" /translation="MDITITLDRSEQADYIYQQIYQKLKKEILSRNLLPHSKVPSKRE LAENLKVSVNSVNSAYQQLLAEGYLYAIERKGFFVEELDMFSAEEHPPFALPDDLKEI HIDQSDWISFSHMSSDTDHFPIKSWFRCEQKAASRSYRTLGDMSHPQGIYEVRAAITR LISLTRGVKCRPEQMIIGAGTQVLMQLLTELLPKEAVYAMEEPGYRRMYQLLKNAGKQ VKTIMLDEKGMSIAEITRQQPDVLVTTPSHQFPSGTIMPVSRRIQLLNWAAEEPRRYI IEDDYDSEFTYDVDSIPALQSLDRFQNVIYMGTFSKSLLPGLRISYMVLPPELLRAYK QRGYDLQTCSSLTQLTLQEFIESGEYQKHIKKMKQHYKEKRERLITALEAEFSGEVTV KGANAGLHFVTEFDTRRTEQDILSHAAGLQLEIFGMSRFNLKENKRQTGRPALIIGFA RLKEEDIQEGVQRLFKAVYGHKKIPVTGD*" /label="gabR CDS" gene complement(421592..423031) /gene="gabR" /locus_tag="BSU_03890" /old_locus_tag="BSU03890" /label="gabR gene" promotor_-10 complement(421916..421927) /Source="Nicolas_upshift_promotors" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(421922) /Source="Nicolas_upshifts" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(421941..421947) /Source="Nicolas_upshift_promotors" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(423074..423093) /Source="Nicolas_upshift_promotors" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 423075..423082 /Source="Nicolas_upshift_promotors" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(423081) /Source="Nicolas_upshifts" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 423096..423115 /Source="Nicolas_upshift_promotors" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 423100 /Source="Nicolas_upshifts" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(423104..423111) /Source="Nicolas_upshift_promotors" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 423138..424448 /gene="gabT" /locus_tag="BSU_03900" /old_locus_tag="BSU03900" /EC_number="2.6.1.19" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:4590473, 12123465, 12354229, 15590624, 9723923, 19854901, 24529384" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4590473, 12123465, 12354229, 15590624, 9723923, 19854901, 24529384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-aminobutyrate aminotransferase" /protein_id="NP_388272.1" /db_xref="EnsemblGenomes-Gn:BSU03900" /db_xref="EnsemblGenomes-Tr:CAB12198" /db_xref="GOA:P94427" /db_xref="InterPro:IPR004632" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12043" /db_xref="UniProtKB/Swiss-Prot:P94427" /translation="MSQTTASITTAQWQQKRDQFVSKGVSNGNRSLAVKGEGAELYDL DGRRFIDFAGAIGTLNVGHSHPKVVEAVKRQAEELIHPGFNVMMYPTYIELAEKLCGI APGSHEKKAIFLNSGAEAVENAVKIARKYTKRQGVVSFTRGFHGRTNMTMSMTSKVKP YKFGFGPFAPEVYQAPFPYYYQKPAGMSDESYDDMVIQAFNDFFIASVAPETVACVVM EPVQGEGGFIIPSKRFVQHVASFCKEHGIVFVADEIQTGFARTGTYFAIEHFDVVPDL ITVSKSLAAGLPLSGVIGRAEMLDAAAPGELGGTYAGSPLGCAAALAVLDIIEEEGLN ERSEEIGKIIEDKAYEWKQEFPFIGDIRRLGAMAAIEIVKDPDTREPDKTKAAAIAAY ANQNGLLLLTAGINGNIIRFLTPLVISDSLLNEGLSILEAGLRA*" /label="gabT CDS" gene 423138..424448 /gene="gabT" /locus_tag="BSU_03900" /old_locus_tag="BSU03900" /label="gabT gene" promotor_-35 424326..424332 /Source="Nicolas_upshift_promotors" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 424346..424364 /Source="Nicolas_upshift_promotors" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 424354 /Source="Nicolas_upshifts" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 424450..424457 /Source="Nicolas_upshift_promotors" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 424472..424491 /Source="Nicolas_upshift_promotors" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 424481 /Source="Nicolas_upshifts" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="upshifts" CDS 424517..425905 /gene="gabD" /locus_tag="BSU_03910" /old_locus_tag="BSU03910" /EC_number="1.2.1.24" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12354229, 15590624, 9723923, 12123465, 24529384, 24809290, 25911692" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15590624, 9723923, 12123465, 24529384, 24809290, 25911692; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate-semialdehyde dehydrogenase" /protein_id="NP_388273.1" /db_xref="EnsemblGenomes-Gn:BSU03910" /db_xref="EnsemblGenomes-Tr:CAB12199" /db_xref="GOA:P94428" /db_xref="InterPro:IPR010102" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="SubtiList:BG12044" /db_xref="UniProtKB/Swiss-Prot:P94428" /translation="MPDQLTVYNPATGEEIKTIPQQSATEVEEAIERSHQAFKTWSKT SANERTSLLKKWYELIVEHKEELADLITKENGKPYQEAVGEVLYGAGYIEWFAEEAKR VYGRTVPAPTTGKRIVVTRQPVGPVAAITPWNFPNAMITRKAAPALAAGCTFIIKPAP DTPLSAYELARLAYEAGIPKDVLQVVIGDGEEIGNVFTSSPKIRKITFTGSTPVGKIL MKNSADTVKHVSMELGGHAPLIVDEDADIDLAVEQAMASKYRNAGQTCVCANRLIVHE SIKDEFAAKLSEQVSKLKVGNGLEEGVNVGPIINKRGFEKIVSQIDDAVEKGAKVIAG GTYDRNDDKGCYFVNPTVLTDVDTSMNIMHEETFGPVAPIVTFSDIDEAIQLANDTPY GLAAYFFTENYRRGIYISENLEYGIIGWNDGGPSAVQAPFGGMKESGIGREGGSEGIE PYLETKYLSIGL*" /label="gabD CDS" gene 424517..425905 /gene="gabD" /locus_tag="BSU_03910" /old_locus_tag="BSU03910" /label="gabD gene" downshifts 425913 /Source="Nicolas_upshifts" /id="D173" /incds=0 /nref=107 /ntot=240 /MaxReadThrough="0.105510000000001" /MaxDrop="6.52053" /score="38.677658" /energy="-19.9" /TU="NA" /idTUdmin="U301" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 425963..425969 /Source="Nicolas_upshift_promotors" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 425983..425994 /Source="Nicolas_upshift_promotors" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 425984 /Source="Nicolas_upshifts" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="upshifts" CDS 426028..426891 /gene="glcU" /locus_tag="BSU_03920" /old_locus_tag="BSU03920" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10438764, 15849754, 16850406, 19054326, 21564334, 27329749; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glucose uptake protein" /protein_id="NP_388274.1" /db_xref="EnsemblGenomes-Gn:BSU03920" /db_xref="EnsemblGenomes-Tr:CAB12200" /db_xref="GOA:P40420" /db_xref="InterPro:IPR010651" /db_xref="SubtiList:BG11066" /db_xref="UniProtKB/Swiss-Prot:P40420" /translation="MDLLLALLPALFWGSIVLFNVKLGGGPYSQTLGTTIGALIVSIV IYFFVQPVLSLRIFIVGIVSGLFWSLGQANQLKSIQLMGVSKTMPISTGMQLVSTSLF GVIVFREWSTPIAITLGVLALIFIIVGIILTSLEDKNDKKEGEPSNLKKGILILLVST LGYLVYVVVARLFNVSGWSALLPQAIGMVVGGLVLTYRHKPFNKYAIRNILPGLIWAG GNMFLFISQPRVGVATSFSLSQMGIVISTLGGIFILREKKTKRQLIAIAIGIILIIAA AVFLGIAKTNS*" /label="glcU CDS" gene 426028..426891 /gene="glcU" /locus_tag="BSU_03920" /old_locus_tag="BSU03920" /label="glcU gene" CDS 426911..427696 /gene="gdh" /locus_tag="BSU_03930" /old_locus_tag="BSU03930" /EC_number="1.1.1.47" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2493633, 3141376, 6438057, 16912926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2493633, 3141376, 6438057, 16912926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="forespore glucose 1-dehydrogenase" /protein_id="NP_388275.1" /db_xref="EnsemblGenomes-Gn:BSU03930" /db_xref="EnsemblGenomes-Tr:CAB12201" /db_xref="GOA:P12310" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10545" /db_xref="UniProtKB/Swiss-Prot:P12310" /translation="MYPDLKGKVVAITGAASGLGKAMAIRFGKEQAKVVINYYSNKQD PNEVKEEVIKAGGEAVVVQGDVTKEEDVKNIVQTAIKEFGTLDIMINNAGLENPVPSH EMPLKDWDKVIGTNLTGAFLGSREAIKYFVENDIKGNVINMSSVHEVIPWPLFVHYAA SKGGIKLMTETLALEYAPKGIRVNNIGPGAINTPINAEKFADPKQKADVESMIPMGYI GEPEEIAAVAAWLASKEASYVTGITLFADGGMTQYPSFQAGRG*" /label="gdh CDS" gene 426911..427696 /gene="gdh" /locus_tag="BSU_03930" /old_locus_tag="BSU03930" /label="gdh gene" misc_feature 427016..427035 /Source="Nicolas_upshift_promotors" /id="U304" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.692307692307692" /psig="0.732267732267732" /xcortree=1477 /SigmaFactorBS="gcttcagggctcggaaaggcgatggccattcgcttcggcaag gagcaggcaaaagtggttATCAACTATTATAGTAATAAacaagatccgaacgaggtaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 427016 /Source="Nicolas_upshifts" /id="U304" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.692307692307692" /psig="0.732267732267732" /xcortree=1477 /SigmaFactorBS="gcttcagggctcggaaaggcgatggccattcgcttcggcaag gagcaggcaaaagtggttATCAACTATTATAGTAATAAacaagatccgaacgaggtaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 427104 /Source="Nicolas_upshifts" /id="D174" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="6.44884" /MaxDrop="2.47712" /score="-5.4075438" /energy="-11.7" /TU="U303" /idTUdmin="U301" /TUdmin=1188 /isTUend="FALSE" /label="downshifts" downshifts 427698 /Source="Nicolas_upshifts" /id="D175" /incds=0 /nref=4 /ntot=40 /MaxReadThrough="2.7861" /MaxDrop="4.2307" /score="-5.4075438" /energy="-11.7" /TU="U303" /idTUdmin="U303" /TUdmin="-836" /isTUend="FALSE" /label="downshifts" CDS complement(427741..428355) /gene="cutI" /locus_tag="BSU_03940" /old_locus_tag="BSU03940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19168619, 22904286, 27010565, 26822828; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative membrane protein involved in copper intake" /protein_id="NP_388276.1" /db_xref="EnsemblGenomes-Gn:BSU03940" /db_xref="EnsemblGenomes-Tr:CAB12202" /db_xref="GOA:P94431" /db_xref="InterPro:IPR012533" /db_xref="SubtiList:BG12045" /db_xref="UniProtKB/Swiss-Prot:P94431" /translation="MLKKIALTLCPAIVGSLLFFTAPASAHVSVKPAESAAGSWETYT MKVPSEKNLPTTKVVLKMPKDVEFQQYEPIPGWKVSTQKHDDKSVSVTWEATDGGIQE GQFQQFTFVAKNPDKAEEAAWDAYQYYKDGSIVEWTGDEDADTPHSITNITSAKQVTD EHGATKTEDDSENSGSSALDITAMVLSAAAIILSVAALVKKKRA*" /label="cutI CDS" gene complement(427741..428355) /gene="cutI" /locus_tag="BSU_03940" /old_locus_tag="BSU03940" /label="cutI gene" downshifts complement(427752) /Source="Nicolas_upshifts" /id="D176" /incds=0 /nref=95 /ntot=219 /MaxReadThrough="0.879290000000001" /MaxDrop="6.67627" /score="21.5633403" /energy="-16" /TU="NA" /idTUdmin="U305" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(428368..429993) /gene="cutJ" /locus_tag="BSU_03950" /old_locus_tag="BSU03950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15101989, 15849754, 16850406, 19168619, 22904286, 23012364" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 15849754, 16850406, 19168619, 22904286, 23012364; Product type t : transporter" /codon_start=1 /transl_table=11 /product="copper import permease subunit" /protein_id="NP_388277.2" /db_xref="EnsemblGenomes-Gn:BSU03950" /db_xref="EnsemblGenomes-Tr:CAB12203" /db_xref="GOA:C0SP95" /db_xref="InterPro:IPR007348" /db_xref="InterPro:IPR008457" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR032693" /db_xref="InterPro:IPR032694" /db_xref="SubtiList:BG12046" /db_xref="UniProtKB/Swiss-Prot:C0SP95" /translation="MKRNRWWIILLLFLVFLPKTSFAHAYIVKSSPGENSELKSAPAQ VEIEFNEPVEEGFHYIKVYNSNGDRVDTDKTEIKKDNHHIMTVKLKKNLPKDVYRAEW NAVSADGHPVSGVIPFSIGKADGGFSSQKAADSALNPGTAADRAILYTALSLFIGTVF FHLFWYKGKSEQLVKRTRRILTGSIAALGLALLLQLPIQTKANAGGGWGSAFQPGYIR ETLFETAGGSIWIIQAALFVLLALSVIPAIRKNRFSSFGYWTAPLIFFFGLLLAKAFT GHAAVVEEKTVGILMDFLHLTSASIWVGGIAALVLLLSKEWRQPDKTLAWETVRRFSP WALTAVGVILFSGLLNGFFIIRSMDSLFHTAYGQALLVKSGLFVFMLVLGAIHFLLTR KQRRTGISRTLKAEWAIGIAVLITAAVFTSLPSPPEPAPEPFYQTKAIENGQSVSLSI SPNQPGKNVFELRVTDHNGDPVKNIQQITLTVYKTGLSGSENKSTFTLKEKTKGVFQD QNLSINEKGNWKIKVHGLTGDFNEINIMFTKTN*" /label="cutJ CDS" gene complement(428368..429993) /gene="cutJ" /locus_tag="BSU_03950" /old_locus_tag="BSU03950" /label="cutJ gene" CDS complement(430028..430600) /gene="cutR" /locus_tag="BSU_03960" /old_locus_tag="BSU03960" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15101989, 22904286, 23012364" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 22904286, 23012364; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of copper intake (CutR-Cu(+))" /protein_id="NP_388278.1" /db_xref="EnsemblGenomes-Gn:BSU03960" /db_xref="EnsemblGenomes-Tr:CAB12204" /db_xref="GOA:P94433" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR008719" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12047" /db_xref="UniProtKB/Swiss-Prot:P94433" /translation="MLPINRQQHILKWLKEEGSLRISDISARFGVSEMTVYRDVNQLV QSNQVIKTAGGITLPVRTPQTDHMCSYCLKPVNQAHSVQLITVNQDIEQLCCAHCAFL RYADKTEEVSHLICRDFLLQTTVSAGSAYFVVNAELNLHCCQPQAIPFATLDHAERFQ KGFGGAVCTFDQALEDMLQDRKKRCTCTKK*" /label="cutR CDS" gene complement(430028..430600) /gene="cutR" /locus_tag="BSU_03960" /old_locus_tag="BSU03960" /label="cutR gene" promotor_-10 complement(430622..430641) /Source="Nicolas_upshift_promotors" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(430637) /Source="Nicolas_upshifts" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(430655..430662) /Source="Nicolas_upshift_promotors" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 430722..430741 /Source="Nicolas_upshift_promotors" /id="U306" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.764235764235764" /psig="0.999000999001" /xcortree=2504 /SigmaFactorBS="aaaaatgtgaaaatgtgttgaacagcaacaaaacgaaacaga agggacTCTGGTATAATAGACAGATGgaatagaaagtgaggaataccctatgaaagaa a" /listShort="ycnL" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 430734 /Source="Nicolas_upshifts" /id="U306" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.764235764235764" /psig="0.999000999001" /xcortree=2504 /SigmaFactorBS="aaaaatgtgaaaatgtgttgaacagcaacaaaacgaaacaga agggacTCTGGTATAATAGACAGATGgaatagaaagtgaggaataccctatgaaagaa a" /listShort="ycnL" /GFF_Attribute="listLong" /label="upshifts" CDS 430765..431118 /gene="ycnL" /locus_tag="BSU_03970" /old_locus_tag="BSU03970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 18307109, 27010565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative reductase or disulfide isomerase" /protein_id="NP_388279.1" /db_xref="EnsemblGenomes-Gn:BSU03970" /db_xref="EnsemblGenomes-Tr:CAB12205" /db_xref="GOA:P94434" /db_xref="SubtiList:BG12048" /db_xref="UniProtKB/Swiss-Prot:P94434" /translation="MKETPCPNCGKPLTGDMVRSSNVPCQFRCGHCRERLYEYKVSAP IMLVSLAAIVLLIYLLMLLRNAAGSVLPAVQHVPMAVFALVCAYPVFIVSERMIAKYV IQNGNIIYRGKRKGS*" /label="ycnL CDS" gene 430765..431118 /gene="ycnL" /locus_tag="BSU_03970" /old_locus_tag="BSU03970" /label="ycnL gene" downshifts 431089 /Source="Nicolas_upshifts" /id="D177" /incds=0 /nref=136 /ntot=248 /MaxReadThrough="0.860829999999999" /MaxDrop="6.25982" /score="38.4886131" /energy="-13.4" /TU="NA" /idTUdmin="U306" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-35 431182..431189 /Source="Nicolas_upshift_promotors" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 431203..431222 /Source="Nicolas_upshift_promotors" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 431208 /Source="Nicolas_upshifts" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="upshifts" S_feature 431218..431290 /Source="Nicolas_S_feature" /locus_tag="new_449651_449723" /HighExp="S0, dia5, Gly, G135, B60, T0.30H, BT, G180, G150, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S132" CDS 431291..432727 /gene="mtlA" /locus_tag="BSU_03981" /old_locus_tag="BSU03981" /EC_number="2.7.1.197" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) mannitol-specific enzyme IICB component" /protein_id="NP_388280.2" /db_xref="EnsemblGenomes-Gn:BSU03981" /db_xref="EnsemblGenomes-Tr:CAB12206" /db_xref="GOA:P42956" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR004718" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013014" /db_xref="InterPro:IPR029503" /db_xref="InterPro:IPR036095" /db_xref="SubtiList:BG11215" /db_xref="UniProtKB/Swiss-Prot:P42956" /translation="MQQQEQQQGGMKVKVQRFGSYLSGMIMPNIGAFIAWGIITALFI PAGWFPNEQLNTLVSPMITYLLPLLIAYTGGKMIYDHRGGVVGATAAIGVIVGSDIPM FLGAMIMGPLGGYLIKQTDKLFKDKVKQGFEMLINNFTAGIVGAALTILAFYAIGPVV LTLNKLLAAGVEVIVHANLLPVASVFVEPAKVLFLNNAINHGILSPIGIEQASQTGKS ILFLVEANPGPGLGILLAYMFFGKGSSKSTAPGAAIIHFFGGIHEIYFPYILMKPALI LAAIAGGASGLLTFTIFNAGLVAAASPGSIIALMAMTPRGGYFGVLAGVLVAAAVSFI VSAVILKSSKASEEDLAAATEKMQSMKGKKSQAAAALEAEQAKAEEASELSPESVNKI IFACDAGMGSSAMGASILRNKVKKAELDISVTNTAINNLPSDADIVITHKDLTDRAKA KLPNATHISVDNFLNSPKYDELIEKLKK*" /label="mtlA CDS" gene 431291..432727 /gene="mtlA" /locus_tag="BSU_03981" /old_locus_tag="BSU03981" /label="mtlA gene" CDS 432752..433183 /gene="mtlF" /locus_tag="BSU_03982" /old_locus_tag="BSU03982" /EC_number="2.7.1.197" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) mannitol-specific enzyme IIA component" /protein_id="YP_003097678.1" /db_xref="EnsemblGenomes-Gn:BSU03982" /db_xref="EnsemblGenomes-Tr:CAX52549" /db_xref="GOA:C0H3V2" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR016152" /db_xref="UniProtKB/Swiss-Prot:C0H3V2" /translation="MQVLAKENIKLNQTVSSKEEAIKLAGQTLIDNGYVTEDYISKMF EREETSSTFMGNFIAIPHGTEEAKSEVLHSGISIIQIPEGVEYGEGNTAKVVFGIAGK NNEHLDILSNIAIICSEEENIERLISAKSEEDLIAIFNEVN*" /label="mtlF CDS" gene 432752..433183 /gene="mtlF" /locus_tag="BSU_03982" /old_locus_tag="BSU03982" /label="mtlF gene" CDS 433185..434306 /gene="mtlD" /locus_tag="BSU_03990" /old_locus_tag="BSU03990" /EC_number="1.1.1.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 22014119, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 22014119, 23279188; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="mannitol-1-phosphate 5-dehydrogenase" /protein_id="NP_388281.2" /db_xref="EnsemblGenomes-Gn:BSU03990" /db_xref="EnsemblGenomes-Tr:CAB12207" /db_xref="GOA:P42957" /db_xref="InterPro:IPR000669" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013118" /db_xref="InterPro:IPR013131" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR023027" /db_xref="InterPro:IPR023028" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11216" /db_xref="UniProtKB/Swiss-Prot:P42957" /translation="MIALHFGAGNIGRGFIGALLHHSGYDVVFADVNETMVSLLNEKK EYTVELAEEGRSSEIIGPVSAINSGSQTEELYRLMNEAALITTAVGPNVLKLIAPSIA EGLRRRNTANTLNIIACENMIGGSSFLKKEIYSHLTEAEQKSVSETVGFPNSAVDRIV PIQHHEDPLKVSVEPFFEWVIDESGFKGKTPVINGALFVDDLTPYIERKLFTVNTGHA VTAYVGYQRGLKTVKEAIDHPEIRRVVHSALLETGDYLVKSYGFKQTEHEQYIKKIIG RFENPFISDDVTRVARSPLRKLGENDRLVGPAKKIKEPNALAEGIAAALRFDFTGDPE AVELQALIEEKGYSGVLQEVCGIQSHEPLHAIILKKLNQ*" /label="mtlD CDS" gene 433185..434306 /gene="mtlD" /locus_tag="BSU_03990" /old_locus_tag="BSU03990" /label="mtlD gene" downshifts 434289 /Source="Nicolas_upshifts" /id="D178" /incds=0 /nref=46 /ntot=156 /MaxReadThrough="5.56503" /MaxDrop="4.72154" /score="32.3837677" /energy="-13.4" /TU="U307" /idTUdmin="U308" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" promotor_-35 434335..434338 /Source="Nicolas_upshift_promotors" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="promotor_-35" promotor_-10 434354..434373 /Source="Nicolas_upshift_promotors" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="promotor_-10" upshifts 434356 /Source="Nicolas_upshifts" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="upshifts" CDS 434397..435461 /gene="ycsA" /locus_tag="BSU_04000" /old_locus_tag="BSU04000" /EC_number="1.1.1.93" /EC_number="1.1.1.83" /EC_number="4.1.1.73" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10568751, 12356321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tartrate dehydrogenase" /protein_id="NP_388282.3" /db_xref="EnsemblGenomes-Gn:BSU04000" /db_xref="EnsemblGenomes-Tr:CAB12208" /db_xref="GOA:P42958" /db_xref="InterPro:IPR011829" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="SubtiList:BG11222" /db_xref="UniProtKB/Swiss-Prot:P42958" /translation="MTMKQFEIAAIPGDGVGKEVVAAAEKVLHTAAEVHGGLSFSFTA FPWSCDYYLEHGKMMPEDGIHTLTQFEAVFLGAVGNPKLVPDHISLWGLLLKIRRELE LSINMRPAKQMAGITSPLLHPNDFDFVVIRENSEGEYSEVGGRIHRGDDEIAIQNAVF TRKATERVMRFAFELAKKRRSHVTSATKSNGIYHAMPFWDEVFQQTAADYSGIETSSQ HIDALAAFFVTRPETFDVIVASNLFGDILTDISSSLMGSIGIAPSANINPSGKYPSMF EPVHGSAPDIAGQGLANPIGQIWTAKLMLDHFGEEELGAKILDVMEQVTADGIKTRDI GGQSTTAEVTDEICSRLRKL*" /label="ycsA CDS" gene 434397..435461 /gene="ycsA" /locus_tag="BSU_04000" /old_locus_tag="BSU04000" /label="ycsA gene" promotor_-35 434631..434639 /Source="Nicolas_upshift_promotors" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 434653..434672 /Source="Nicolas_upshift_promotors" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 434663 /Source="Nicolas_upshifts" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 435455 /Source="Nicolas_upshifts" /id="D179" /incds=0 /nref=7 /ntot=41 /MaxReadThrough="4.24123" /MaxDrop="4.42639" /score="9.70532694" /energy="-11.6" /TU="U307,U308" /idTUdmin="U308" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-35 435528..435535 /Source="Nicolas_upshift_promotors" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 435548..435567 /Source="Nicolas_upshift_promotors" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 435561 /Source="Nicolas_upshifts" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="upshifts" CDS 435596..436159 /gene="sipU" /locus_tag="BSU_04010" /old_locus_tag="BSU04010" /EC_number="3.4.21.89" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9325333, 10198007, 11856304, 14568161" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 10198007, 11856304, 14568161; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_388283.1" /db_xref="EnsemblGenomes-Gn:BSU04010" /db_xref="EnsemblGenomes-Tr:CAB12209" /db_xref="GOA:P42959" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG11223" /db_xref="UniProtKB/Swiss-Prot:P42959" /translation="MNAKTITLKKKRKIKTIVVLSIIMIAALIFTIRLVFYKPFLIEG SSMAPTLKDSERILVDKAVKWTGGFHRGDIIVIHDKKSGRSFVKRLIGLPGDSIKMKN DQLYINDKKVEEPYLKEYKQEVKESGVTLTGDFEVEVPSGKYFVMGDNRLNSLDSRNG MGMPSEDDIIGTESLVFYPFGEMRQAK*" /label="sipU CDS" gene 435596..436159 /gene="sipU" /locus_tag="BSU_04010" /old_locus_tag="BSU04010" /label="sipU gene" S_feature 436160..436884 /Source="Nicolas_S_feature" /locus_tag="new_454593_455317" /HighExp="G150, Oxctl, Lbexp, G135, Paraq, dia0, LBGexp, Mt0, G180, dia15" /AntisenseName="yczH" /AntisenseCor="0.134432865921808" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.996, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S133" CDS complement(436219..436827) /gene="yczH" /locus_tag="BSU_04020" /old_locus_tag="BSU04020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388284.2" /db_xref="EnsemblGenomes-Gn:BSU04020" /db_xref="EnsemblGenomes-Tr:CAB12210" /db_xref="GOA:O31482" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12782" /db_xref="UniProtKB/Swiss-Prot:O31482" /translation="MFPKPLVILAHEIYGVNSHMKKMGRLIKMAGYDVLTPNLLGEDE VYTLKEEKTAYEQFTKHERLKTGETIIQNVIRQNAGRHIFVIGFSVGATIAWKCSSMP EVSGSVCYYGSRIRDSLHHMPACPVLLFFPNYEPSFDVALLIKKLREKQHTHLEIYQF DALHGFANPDSVYFNRALFFKTLSIIKNGAESRLRTVSSSFF*" /label="yczH CDS" gene complement(436219..436827) /gene="yczH" /locus_tag="BSU_04020" /old_locus_tag="BSU04020" /label="yczH gene" misc_feature complement(436845..436864) /Source="Nicolas_upshift_promotors" /id="U311" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.397602397602398" /psig="0.993006993006993" /xcortree=2931 /SigmaFactorBS="aagataatgagttcattttatatctcctttttttgaccatta tatctcagcctaaagtgaaacgATAGGATATAATGGAAAAAAcacaaaaggaggccgt t" /listShort="yczH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 436861..436867 /Source="Nicolas_upshift_promotors" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(436868) /Source="Nicolas_upshifts" /id="U311" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.397602397602398" /psig="0.993006993006993" /xcortree=2931 /SigmaFactorBS="aagataatgagttcattttatatctcctttttttgaccatta tatctcagcctaaagtgaaacgATAGGATATAATGGAAAAAAcacaaaaggaggccgt t" /listShort="yczH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 436880..436899 /Source="Nicolas_upshift_promotors" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 436886 /Source="Nicolas_upshifts" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="upshifts" CDS 436913..437305 /gene="ycsD" /locus_tag="BSU_04030" /old_locus_tag="BSU04030" /EC_number="4.2.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 16291680, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydroxyacyl-(acyl carrier protein) dehydratase" /protein_id="NP_388285.2" /db_xref="EnsemblGenomes-Gn:BSU04030" /db_xref="EnsemblGenomes-Tr:CAB12211" /db_xref="InterPro:IPR013114" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG11225" /db_xref="UniProtKB/Swiss-Prot:P42961" /translation="MNSLSLPHRYPFLFIDGVTDSEPGKHAAAYKLISENDWFITDTQ TEMPFSLVIEALAQTAAFTGITDENSLGLLSSVKKAEKLGEAVPGDRLDLTFEVTRNR RGFVFGHAKASVGEQPVAEAEIGIYIEK*" /label="ycsD CDS" gene 436913..437305 /gene="ycsD" /locus_tag="BSU_04030" /old_locus_tag="BSU04030" /label="ycsD gene" downshifts 437282 /Source="Nicolas_upshifts" /id="D180" /incds=0 /nref=23 /ntot=189 /MaxReadThrough="1.8721" /MaxDrop="3.42324" /score="-5.4921522" /energy="-13.6" /TU="NA" /idTUdmin="U310" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(437338..437502) /gene="yczO" /locus_tag="BSU_04039" /old_locus_tag="BSU04039" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097679.1" /db_xref="EnsemblGenomes-Gn:BSU04039" /db_xref="EnsemblGenomes-Tr:CAX52550" /db_xref="UniProtKB/Swiss-Prot:C0H3V3" /translation="MTEKKQQNKPNENPEHNDLTDPIPNEELKENMNDEKHKRQQRDN SQSERDYDTK*" /label="yczO CDS" gene complement(437338..437502) /gene="yczO" /locus_tag="BSU_04039" /old_locus_tag="BSU04039" /label="yczO gene" downshifts complement(437358) /Source="Nicolas_upshifts" /id="D181" /incds=0 /nref=101 /ntot=193 /MaxReadThrough="1.44096" /MaxDrop="6.55741" /score="22.582242" /energy="-10.6" /TU="NA" /idTUdmin="U313" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(437512..437530) /Source="Nicolas_upshift_promotors" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(437534) /Source="Nicolas_upshifts" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(437545..437551) /Source="Nicolas_upshift_promotors" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 437564..437571 /Source="Nicolas_upshift_promotors" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 437585..437604 /Source="Nicolas_upshift_promotors" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 437588 /Source="Nicolas_upshifts" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="upshifts" CDS 437635..438384 /gene="ribZ" /locus_tag="BSU_04040" /old_locus_tag="BSU04040" /EC_number="3.1.3.-" /function="4.9: Riboflavin, FMN, and FAD" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 26316208, 27435445, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-amino-6-ribitylamino-2,4(1H, 3H)-pyrimidinedione 5'-phosphate phosphatase / 5' nucleotidase" /protein_id="NP_388286.2" /db_xref="EnsemblGenomes-Gn:BSU04040" /db_xref="EnsemblGenomes-Tr:CAB12212" /db_xref="GOA:P42962" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11226" /db_xref="UniProtKB/Swiss-Prot:P42962" /translation="MSVQREDVDIKLIAIDMDGTLLNDEQLISDENRKAIREAEDKGV YVVISTGRTLMTCRELAESLKLSSFLITANGSEIWDSNFNLVERKLLHTDHIQMMWDL RNKHNTNFWASTVNKVWRGEFPENITDHEWLKFGFDIEDDDIRNEVLEELRKNKELEI TNSSPTNIEVNALGINKAAALAKVTEKLGFTMENVMAMGDSLNDIAMIKEAGLGVAMG NAQDIVKETADYITDTNIEDGVAKAIRHWVL*" /label="ribZ CDS" gene 437635..438384 /gene="ribZ" /locus_tag="BSU_04040" /old_locus_tag="BSU04040" /label="ribZ gene" downshifts 438361 /Source="Nicolas_upshifts" /id="D182" /incds=0 /nref=219 /ntot=253 /MaxReadThrough="3.23506" /MaxDrop="6.84998" /score="19.5535298" /energy="-11.7" /TU="NA" /idTUdmin="U314" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" downshifts complement(438437) /Source="Nicolas_upshifts" /id="D183" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="0.52326" /MaxDrop="2.84763" /score="25.9755124" /energy="-11.7" /TU="NA" /idTUdmin="U313" /TUdmin="-1079" /isTUend="FALSE" /label="downshifts" promotor_-35 438467..438473 /Source="Nicolas_upshift_promotors" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 438487..438506 /Source="Nicolas_upshift_promotors" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 438493..438589 /Source="Nicolas_S_feature" /locus_tag="new_456926_457022" /HighExp="S1, Cold, S0, GM 5, BMM, MG 25, Lbtran, aero, GM 10, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S134" upshifts 438493 /Source="Nicolas_upshifts" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="upshifts" CDS 438590..439363 /gene="pxpA" /locus_tag="BSU_04050" /old_locus_tag="BSU04050" /EC_number="3.5.2.9" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9334321, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxoprolinase subunit A" /protein_id="NP_388287.3" /db_xref="EnsemblGenomes-Gn:BSU04050" /db_xref="EnsemblGenomes-Tr:CAB12213" /db_xref="GOA:P42963" /db_xref="InterPro:IPR005501" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG11227" /db_xref="UniProtKB/Swiss-Prot:P42963" /translation="MFQIDLNCDLGESFGAYKIGLDQDILEYVTSANIACGFHAGDPS VMRKTVALAAERGVKMGAHPGLPDLLGFGRRNMAISPEEAYDLVVYQIGALSGFLKAE GLHMQHVKPHGALYNMAAVDQKLSDAIAKAVYKVDPGLILFGLAESELVKAGERIGLQ TANEVFADRTYQSDGTLTPRSQPDALIESDDAAVTQVIKMVKEGAVKSQQGHDVSLKA DTVCIHGDGAHALTFAQKIRKQLKAAGIEVTAISEQRST*" /label="pxpA CDS" gene 438590..439363 /gene="pxpA" /locus_tag="BSU_04050" /old_locus_tag="BSU04050" /label="pxpA gene" CDS 439378..440592 /gene="pxpG" /locus_tag="BSU_04060" /old_locus_tag="BSU04060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9334321, 15849754, 16850406, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-oxoproline transporter" /protein_id="NP_388288.3" /db_xref="EnsemblGenomes-Gn:BSU04060" /db_xref="EnsemblGenomes-Tr:CAB12214" /db_xref="GOA:P42964" /db_xref="InterPro:IPR001046" /db_xref="SubtiList:BG11228" /db_xref="UniProtKB/Swiss-Prot:P42964" /translation="MEQQKKTAGKKAGSWSLLMGAAFLMATSAIGPGFLTQTATFTNT LAASFGFVILISIILDIFAQTNVWRIIAVSGKRGQEIANMVLPGLGYFIAILVVLGGL AFNIGNIGGAGLGLQVLFGITPETGALISAVIAILIFVIKEAGKAMDRFTQIAGFVMI ILTVYVAATTAPPVGQAVANTFVPEHISIFAIVTLVGGTVGGYITFAGGHRLLDAGIK GKESIPQVTKSSVVGILITSVMRIALFLAVLGVVSKGLHIDESNPAASVFKLAAGNVG YKIFGLIMWSAAITSVIGAAYTSVSFFKTFSPKIEKNSRGIIIGFIVVSTLAFVTIGQ PAKILVLVGSLNGLILPIALGTLLVAAYKKNIVGDYKHPLWLTSTGALVVIVMAVMGI YTLCTQLPQLWS*" /label="pxpG CDS" gene 439378..440592 /gene="pxpG" /locus_tag="BSU_04060" /old_locus_tag="BSU04060" /label="pxpG gene" CDS 440616..441389 /gene="pxpI" /locus_tag="BSU_04070" /old_locus_tag="BSU04070" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8186229, 9334321, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative D-5-oxoproline epimerase" /protein_id="NP_388289.3" /db_xref="EnsemblGenomes-Gn:BSU04070" /db_xref="EnsemblGenomes-Tr:CAB12215" /db_xref="GOA:P42966" /db_xref="InterPro:IPR009906" /db_xref="InterPro:IPR016938" /db_xref="SubtiList:BG11230" /db_xref="UniProtKB/Swiss-Prot:P42966" /translation="MAPKDVRALIREGKINGPTAGMSGGYAQANLVVLKKDLAFDFLL FCQRNQKPCPVLDVTEAGSPVPSLAAPDADIRTDFPKYRIYRHGILTEEVSDITPYWE DDFVGFLIGCSFSFEQALINNGIAVRHIDEGTNVSMYKTNIDCVPAGAFHGQMVVSMR PVPERLAVRAAQVTSRFPAVHGGPIHIGNPGAIGIRDLGKPDFGDAVSIRDGEVPVFW ACGVTPQAVAMNVKPEMVITHAPGHMLITDIRDESLAVL*" /label="pxpI CDS" gene 440616..441389 /gene="pxpI" /locus_tag="BSU_04070" /old_locus_tag="BSU04070" /label="pxpI gene" CDS 441434..442156 /gene="pxpB" /locus_tag="BSU_04080" /old_locus_tag="BSU04080" /EC_number="3.5.2.9" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-5-oxoprolinase (ATP-dependent) subunit B" /protein_id="NP_388290.2" /db_xref="EnsemblGenomes-Gn:BSU04080" /db_xref="EnsemblGenomes-Tr:CAB12216" /db_xref="GOA:P60495" /db_xref="InterPro:IPR003833" /db_xref="InterPro:IPR010016" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR029000" /db_xref="PDB:2KWA" /db_xref="PDB:2ZP2" /db_xref="SubtiList:BG11231" /db_xref="UniProtKB/Swiss-Prot:P60495" /translation="MTVRYQIEQLGDSAMMIRFGEEINEQVNGIVHAAAAYIEEQPFP GFIECIPAFTSLTVFYDMYEVYKHLPQGISSPFESVKRDVEERLAEIAEDYEVNRRIV EIPVCYGGEFGPDLEEVAKINQLSPEEVIDIHTNGEYVVYMLGFAPGFPFLGGMSKRI AAPRKSSPRPSIPAGSVGIAGLQTGVYPISTPGGWQLIGKTPLALFRPQENPPTLLRA GDIVKFVRISEKDYHAYKEESN*" /label="pxpB CDS" gene 441434..442156 /gene="pxpB" /locus_tag="BSU_04080" /old_locus_tag="BSU04080" /label="pxpB gene" CDS 442159..443166 /gene="pxpC" /locus_tag="BSU_04090" /old_locus_tag="BSU04090" /EC_number="3.5.2.9" /function="16.6: Maintain" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-5-oxoprolinase (ATP-dependent) subunit C" /protein_id="YP_054571.2" /db_xref="EnsemblGenomes-Gn:BSU04090" /db_xref="EnsemblGenomes-Tr:CAE01447" /db_xref="GOA:Q7WY77" /db_xref="InterPro:IPR003778" /db_xref="InterPro:IPR029000" /db_xref="SubtiList:BG14193" /db_xref="UniProtKB/Swiss-Prot:Q7WY77" /translation="MKVLKPGLLTTVQDIGRTGYQKYGVLASGAMDTVSLRIANLLIG NGENEAGLEITMMGPGPSFHFSKQTLIAVTGADFTLRINDEEAPLWKPVLIKENSTVS FGPCKLGSRAYLAAAGGIEVPAVMESKSTYVRGSIGGLHGRALQKEDELNIGEMSALS QTILSRLSSQLGKQGFAAPKWSVSRGRFLPLKKNPVIRVLEGKQFAFFTEESKTRFYE EAFRVTPQSDRMGYRLKGEPLELKAPLEMVSEAVSFGTVQVPPDGNPIILLADRQTTG GYPRIAHIISADLPIVSQIMPGEHVQFEPVSLQEAEALAVEREQHIKELKTRMKMEWL T*" /label="pxpC CDS" gene 442159..443166 /gene="pxpC" /locus_tag="BSU_04090" /old_locus_tag="BSU04090" /label="pxpC gene" downshifts 442652 /Source="Nicolas_upshifts" /id="D184" /incds=1 /nref=6 /ntot=27 /MaxReadThrough="5.04721" /MaxDrop="4.5277" /score="-7.2426149" /energy="-12.4" /TU="U315" /idTUdmin="U315" /TUdmin="-1975" /isTUend="FALSE" /label="downshifts" promotor_no_box 442746..442846 /Source="Nicolas_upshift_promotors" /id="U316" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.020979020979021" /xcortree=1726 /SigmaFactorBS="cattcgggtgctggaaggaaagcaatttgcctttttcacaga agaatcaaaaacgcgtttttatgaagaagcatttcgtgtcacgccgcagtccgaccgt a" /listShort="kipR, lipC" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 442806 /Source="Nicolas_upshifts" /id="U316" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.020979020979021" /xcortree=1726 /SigmaFactorBS="cattcgggtgctggaaggaaagcaatttgcctttttcacaga agaatcaaaaacgcgtttttatgaagaagcatttcgtgtcacgccgcagtccgaccgt a" /listShort="kipR, lipC" /GFF_Attribute="listLong" /label="upshifts" CDS 443182..443934 /gene="pxpR" /locus_tag="BSU_04100" /old_locus_tag="BSU04100" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9334321; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the pxp operon (IclR family)" /protein_id="NP_388291.2" /db_xref="EnsemblGenomes-Gn:BSU04100" /db_xref="EnsemblGenomes-Tr:CAB12217" /db_xref="GOA:P42968" /db_xref="InterPro:IPR005471" /db_xref="InterPro:IPR014757" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11214" /db_xref="UniProtKB/Swiss-Prot:P42968" /translation="MQNKNKTVVKSMALLNLFLHKPSLTLSELVSLTGMPKTSVHRMV SSLEEMGFLSRDASGAYSLGLVFLEFGQLVADRLDIRKIAKPVMEELCREVDEAVQLI MRDGNEAIYVEKIEGTQTVRLYTAIGRRSPLYAGACARSILSFLPREEIEAYIKQTEL ISIGSGTITDPEKLLQEIDASVQNGYTVSYSELENYTAAIGAPIFNHERQVAAGISIA GFEARFTEDRLPYLTEKVKDAALQISRKIGYT*" /label="pxpR CDS" gene 443182..443934 /gene="pxpR" /locus_tag="BSU_04100" /old_locus_tag="BSU04100" /label="pxpR gene" promotor_-35 443932..443941 /Source="Nicolas_upshift_promotors" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 443955..443974 /Source="Nicolas_upshift_promotors" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 443965 /Source="Nicolas_upshifts" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="upshifts" CDS 443998..444639 /gene="lipC" /locus_tag="BSU_04110" /old_locus_tag="BSU04110" /EC_number="3.1.1.-" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9334321, 17220230, 20057119" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 17220230, 20057119; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat phospholipase B" /protein_id="NP_388292.1" /db_xref="EnsemblGenomes-Gn:BSU04110" /db_xref="EnsemblGenomes-Tr:CAB12218" /db_xref="GOA:P42969" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG11232" /db_xref="UniProtKB/Swiss-Prot:P42969" /translation="MVLRYTALGDSLTTGRGSGLFSPGFVQRFGDMMEADLKTRTAIN IFARSGLNTEEILGLLSYPYVQKCIRDADMITITGCGNDLIDSVLAYQTSKDETIFSR VSAHCHENFEKMIAKVAEIKGENPSPYAIRVFNLYNPFPEIDIAGKWITSFNSHLETL ASAPHVKIADAYSIFKGKEQEYLSFDGVHPNSKGYQAMAEAVHKLGYKELSVS*" /label="lipC CDS" gene 443998..444639 /gene="lipC" /locus_tag="BSU_04110" /old_locus_tag="BSU04110" /label="lipC gene" downshifts 444625 /Source="Nicolas_upshifts" /id="D185" /incds=0 /nref=106 /ntot=223 /MaxReadThrough="0.550230000000001" /MaxDrop="6.63515" /score="26.7371783" /energy="-11.8" /TU="NA" /idTUdmin="U315" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(444637..445062) /Source="Nicolas_S_feature" /locus_tag="new_463070_463495_c" /HighExp="S1, Sw, BC, S2, Lbtran, M0t90, LPhT, BI, M40t45, C90" /AntisenseName="yczI" /AntisenseCor="-0.57558682544748696" /AntisenseRegPval="-24.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S135" downshifts complement(444682) /Source="Nicolas_upshifts" /id="D186" /incds=0 /nref=171 /ntot=252 /MaxReadThrough="1.91715" /MaxDrop="5.13764" /score="6.4765859" /energy="-11.8" /TU="NA" /idTUdmin="U319" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 444715..444721 /Source="Nicolas_upshift_promotors" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 444735..444754 /Source="Nicolas_upshift_promotors" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 444736 /Source="Nicolas_upshifts" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="upshifts" CDS 444812..445057 /gene="yczI" /locus_tag="BSU_04120" /old_locus_tag="BSU04120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388293.1" /db_xref="EnsemblGenomes-Gn:BSU04120" /db_xref="EnsemblGenomes-Tr:CAB12219" /db_xref="GOA:P42970" /db_xref="InterPro:IPR025018" /db_xref="SubtiList:BG12783" /db_xref="UniProtKB/Swiss-Prot:P42970" /translation="MFRIFKMSFAVIIIILALIAFNYTEHTSVIQSVMLVFLGAVMFM QGLEERKKENDGSGAFNIYTAVFVWSVSLIGFTLHII*" /label="yczI CDS" gene 444812..445057 /gene="yczI" /locus_tag="BSU_04120" /old_locus_tag="BSU04120" /label="yczI gene" S_feature 445058..445468 /Source="Nicolas_S_feature" /locus_tag="new_463491_463901" /HighExp="T5.0H, T2.30H, T3.30H, T2.0H, T3.0H, T4.0H, T1.30H, M9-stat, T-4.40H, T-3.40H" /AntisenseName="yczJ" /AntisenseCor="-0.20847541933848601" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S136" CDS complement(445063..445350) /gene="yczJ" /locus_tag="BSU_04130" /old_locus_tag="BSU04130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388294.1" /db_xref="EnsemblGenomes-Gn:BSU04130" /db_xref="EnsemblGenomes-Tr:CAB12220" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="SubtiList:BG12784" /db_xref="UniProtKB/Swiss-Prot:O31484" /translation="MVREAAMLHIKEGLEQEFEDAFRQAAPIISGMKGYITHSLSKCM EETHKYLLLVEWETLEDHTEGFRGSSEYQEWKALLHRFYTPFPTVEHFQDV*" /label="yczJ CDS" gene complement(445063..445350) /gene="yczJ" /locus_tag="BSU_04130" /old_locus_tag="BSU04130" /label="yczJ gene" misc_feature complement(445371..445390) /Source="Nicolas_upshift_promotors" /id="U319" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.542457542457542" /psig="0.965034965034965" /xcortree=1595 /SigmaFactorBS="aagatttttttgaaaatgaaggaaaagttcaccgattttgca gaaatctcctatcgtTTGCTGTAGACTATTTGAAAagacagaaagaagggatagcatg g" /listShort="yczJ, S135" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(445387) /Source="Nicolas_upshifts" /id="U319" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.542457542457542" /psig="0.965034965034965" /xcortree=1595 /SigmaFactorBS="aagatttttttgaaaatgaaggaaaagttcaccgattttgca gaaatctcctatcgtTTGCTGTAGACTATTTGAAAagacagaaagaagggatagcatg g" /listShort="yczJ, S135" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 445444..445448 /Source="Nicolas_upshift_promotors" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 445465..445484 /Source="Nicolas_upshift_promotors" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 445470 /Source="Nicolas_upshifts" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="upshifts" CDS 445501..447507 /gene="pbpC" /locus_tag="BSU_04140" /old_locus_tag="BSU04140" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8830698, 10648534" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830698, 10648534; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="penicillin-binding lipoprotein 3; transpeptidase" /protein_id="NP_388295.1" /db_xref="EnsemblGenomes-Gn:BSU04140" /db_xref="EnsemblGenomes-Tr:CAB12221" /db_xref="GOA:P42971" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR007887" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR032710" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG11234" /db_xref="UniProtKB/Swiss-Prot:P42971" /translation="MLKKCILLVFLCVGLIGLIGCSKTDSPEDRMEAFVKQWNDQQFD DMYQSLTKDVKKEISKKDFVNRYKAIYEQAGVKNLKVTAGEVDKDDQDNKTMKHIPYK VSMNTNAGKVSFKNTAVLKLEKTDDEESWNIDWDPSFIFKQLADDKTVQIMSIEPKRG QIYDKNGKGLAVNTDVPEIGIVPGELGDKKEKVIKELAKKLDLTEDDIKKKLDQGWVK DDSFVPLKKVKPDQEKLVSEATSLQGVTRTNVSSRYYPYGEKTAHLTGYVRAITAEEL KKKKEGTYSDTSNIGIAGLENVYEDKLRGTTGWKIYVPQTGEVIAEKKAKDGEDLHLT IDIKTQMKLYDELKDDSGAAVALQPKTGETLALVSAPSYDPNGFIFGWSDKEWKKLNK DKNNPFSAKFNKTYAPGSTIKPIAAAIGIKNGTLKADEKKTIKGKEWQKDSSWGGYSV TRVSERLQQVDLENALITSDNIYFAQNALDMGADTFTKGLKTFGFSEDVPYEFPIQKS SIANDKLDSDILLADTGYGQGQMQMSPLHLATAYTPFVDNGDLVKPTLIKKDSQTADV WHKQVVTKEGAADITKGLKGVVEDERGSAYQPVVKGITVAGKTGTAELKTSKDDKDGT ENGWFVGYDYENKDLLVAMMIQNVQDRGGSHYVVEKAKKQFQSN*" /label="pbpC CDS" gene 445501..447507 /gene="pbpC" /locus_tag="BSU_04140" /old_locus_tag="BSU04140" /label="pbpC gene" S_feature 447508..447608 /Source="Nicolas_S_feature" /locus_tag="new_465941_466041" /HighExp="LBGstat, T5.0H, M0t45, T3.30H, S0, LBGtran, Oxctl, T4.0H, C30, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.946, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S137" CDS 447609..448511 /gene="ycsN" /locus_tag="BSU_04150" /old_locus_tag="BSU04150" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388296.1" /db_xref="EnsemblGenomes-Gn:BSU04150" /db_xref="EnsemblGenomes-Tr:CAB12222" /db_xref="GOA:P42972" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11235" /db_xref="UniProtKB/Swiss-Prot:P42972" /translation="MQRIQLAEDLQFSRVIHGLWRLNEWNYSDAELLSLIEWCIDHGI TTFDHADIYGGYTCEKLFGNALALSPGLRENIELVTKCGIVLESPERPAHRSHHYNTS KSHILASVEQSLMNLRTDYIDMLLIHRPDPLMDPEGVAEAFQALKCSGKVRYFGVSNF KDHQYRMLESYLPEKLVTNQIELSAYELENMLDGTLNLCQEKRIPPMAWSPLAGGKVF TENTDKDRRVRTALESVQGEIGAASLDEVMYAWLYTHPAGIMPIVGSGKRERISAAIN ALSYKLDQDQWFRIFTAVQGYDIP*" /label="ycsN CDS" gene 447609..448511 /gene="ycsN" /locus_tag="BSU_04150" /old_locus_tag="BSU04150" /label="ycsN gene" downshifts 448491 /Source="Nicolas_upshifts" /id="D187" /incds=0 /nref=48 /ntot=206 /MaxReadThrough="3.20352" /MaxDrop="4.57855" /score="1.36962171" /energy="-10.6" /TU="U320" /idTUdmin="U318" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 448584..448591 /Source="Nicolas_upshift_promotors" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 448605..448624 /Source="Nicolas_upshift_promotors" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 448609..448696 /Source="Nicolas_S_feature" /locus_tag="new_467042_467129" /HighExp="S0, Gly, BC, Lbstat, S2, M9-stat, G135, dia5, T0.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S138" upshifts 448609 /Source="Nicolas_upshifts" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="upshifts" CDS 448697..450781 /gene="mtlR" /locus_tag="BSU_04160" /old_locus_tag="BSU04160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188, 24196428, 26159071" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188, 24196428, 26159071; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator, PTS-dependent activator" /protein_id="NP_388297.1" /db_xref="EnsemblGenomes-Gn:BSU04160" /db_xref="EnsemblGenomes-Tr:CAB12223" /db_xref="GOA:P96574" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG12049" /db_xref="UniProtKB/Swiss-Prot:P96574" /translation="MYMTAREQKLLKHLLLQNRYITVTELAELMQVSTRTIHRELKSI KPLMETVGLTLDKQPGKGLKAVGSPEGKQKLLTDLSYEQHEYSADERKLLILCSLLES QEPVKLYTLAHDLQVTNATVSYDLDELEKWISPFGLTLIRKRGFGIQLIGPENAKRKI VGNLIVNRLDIQMFLEAVELNIKGKTDSSEKMFGVVSKGELLKMERILFQLKEKIAFS LSDSSYIALVVHLTYAIERIKLGETITMEQNELEELMNAKEYSSALEIAGELERAFGV TIPEAEVGYITIHLRSANRKYKTEYKAQEIELETALQTKRLIAFISDKIRMDLTKNYS LYEGLIAHLEPAVSRIKENIEIYNPMKEQIKRDYFLLYMAIEEGVEKYFPGMSFSDDE IAFIVLHFGSALEIKKEEAKVKALVVCSSGIGSSKMLASRLKKELPEIESFDMSSLIE LKGKDVQAYDMIVSTVPIPYENIDYIMVSPLLNEEDANQVKQYIKRKIPLILNKKRSS KEEAQQADVPDMLEAAESIGRYMEVIQDVLRHFTLAQLKTNPDHSMLLLELFQQLKKD GLIRDPEKAAVCLAEREKQGGLGIPGTNMALYHLKNDEIVLPFFKMFDLSTPYEVDGM DGNTLRMTRILVMMAPGSLSAEGSEILSAISSAIIESGESMAGFQEEGGQELYQRLNR IFFTWMKEKNIL*" /label="mtlR CDS" gene 448697..450781 /gene="mtlR" /locus_tag="BSU_04160" /old_locus_tag="BSU04160" /label="mtlR gene" downshifts 450768 /Source="Nicolas_upshifts" /id="D188" /incds=0 /nref=107 /ntot=220 /MaxReadThrough="1.91059" /MaxDrop="5.63565" /score="9.4904968" /energy="-12.4" /TU="NA" /idTUdmin="U321" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-35 450810..450816 /Source="Nicolas_upshift_promotors" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 450830..450848 /Source="Nicolas_upshift_promotors" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 450842 /Source="Nicolas_upshifts" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="upshifts" S_feature 450853..450934 /Source="Nicolas_S_feature" /locus_tag="new_469286_469367" /HighExp="Etha, S5, S6, ferm, S8, nit, S7, BT, Salt, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S139" promotor_-35 450896..450903 /Source="Nicolas_upshift_promotors" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 450917..450936 /Source="Nicolas_upshift_promotors" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 450936 /Source="Nicolas_upshifts" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="upshifts" CDS 450993..452504 /gene="ydaB" /locus_tag="BSU_04170" /old_locus_tag="BSU04170" /EC_number="6.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA ligase" /protein_id="NP_388298.2" /db_xref="EnsemblGenomes-Gn:BSU04170" /db_xref="EnsemblGenomes-Tr:CAB12224" /db_xref="GOA:P96575" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG12050" /db_xref="UniProtKB/Swiss-Prot:P96575" /translation="METLQHLILHDMPNSEEIEAVKSGDHTLTYKGYRKRINQLANAM LQKGIQKGDRVALLCKNGHPASTVMFAALEIGAVVVPVSWQLKPYEMTGILKASEPKA MFYGAEFKEILDEVLPELSSLCVTMETGTAYETSAEFEALFAGPDHLPETEMVSPDDT ALLMFTSGTTGNPKRCMITHGGIYRYVKKSNSSIARMKGLRFLACHPIYHTSALICIM LGTFAETTFVFTKDQDPVHMLKVIEEEKIQTVMALPVFYTYLLEAWEKHQTDLSSLVI LMTGGTKVPSSLISRYLDIGIPLAHGYGSTEAWGISTWTPDMGMDKAASAGKPVAGVK VKVEDPLTGEELPQGEIGEIVVHTPFLFKGYEDNPEATAKVLQNGWFRTGDSGYVDED GFIFITGRYKDVIIYGGDNVYPDQVEEVIQQIPGILETAVVGIPDPLYGEKPKAFIVK NGGQRITEEDVIAFCKERLSAYKIPEVEFVNELPKNNLGKVKKDVLRNQAVHS*" /label="ydaB CDS" gene 450993..452504 /gene="ydaB" /locus_tag="BSU_04170" /old_locus_tag="BSU04170" /label="ydaB gene" downshifts 452488 /Source="Nicolas_upshifts" /id="D189" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="0.57376" /MaxDrop="3.70168" /score="9.4904968" /energy="-12.4" /TU="NA" /idTUdmin="U323" /TUdmin=73 /isTUend="FALSE" /label="downshifts" CDS complement(452524..453069) /gene="ydaC" /locus_tag="BSU_04180" /old_locus_tag="BSU04180" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_388299.1" /db_xref="EnsemblGenomes-Gn:BSU04180" /db_xref="EnsemblGenomes-Tr:CAB12225" /db_xref="GOA:P96576" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12051" /db_xref="UniProtKB/Swiss-Prot:P96576" /translation="MIAGYIMAAENQTLNQWTINQLGITRGDSILEVGFGPGYCMQQM LKREKDVHLHGIDVSEAMLKLAARRVKPKGVRLIQGSIETFPLPASFYDKVISVNNYT IWNDQTKGIKQIYRALKPGGKAAITMQPREADASPEKTKSFGRQMIADFKAAGFEDID IQFKNIKPELSVCATAKKPAT*" /label="ydaC CDS" gene complement(452524..453069) /gene="ydaC" /locus_tag="BSU_04180" /old_locus_tag="BSU04180" /label="ydaC gene" downshifts complement(452557) /Source="Nicolas_upshifts" /id="D190" /incds=0 /nref=3 /ntot=11 /MaxReadThrough="1.44039" /MaxDrop="3.73662" /score="-9.35066962" /energy="-11.5" /TU="NA" /idTUdmin="U324" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(453136..453154) /Source="Nicolas_upshift_promotors" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(453150) /Source="Nicolas_upshifts" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(453169..453175) /Source="Nicolas_upshift_promotors" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 453211..453217 /Source="Nicolas_upshift_promotors" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="promotor_-35" upshifts 453229 /Source="Nicolas_upshifts" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="upshifts" promotor_-10 453232..453250 /Source="Nicolas_upshift_promotors" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="promotor_-10" CDS 453276..454136 /gene="ydaD" /locus_tag="BSU_04190" /old_locus_tag="BSU04190" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 11948145, 15805528, 21520290, 28197687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase" /protein_id="NP_388300.1" /db_xref="EnsemblGenomes-Gn:BSU04190" /db_xref="EnsemblGenomes-Tr:CAB12226" /db_xref="GOA:P80873" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12052" /db_xref="UniProtKB/Swiss-Prot:P80873" /translation="MANYPKELPAQTQSRQPGIESEMNPSPVYEYEDYKGADKLKGKV ALITGGDSGIGRAVSVAYAKEGADIAIVYKDEHEDAEETKKRVEQEGVKCLLIAGDVG EEEFCNEAVEKTVKELGGLDILVNNAGEQHPKESIKDITSEQLHRTFKTNFYSQFYLT KKAIDYLKPGSAIINTTSINPYVGNPTLIDYTATKGAINAFTRTMAQALVKDGIRVNA VAPGPIWTPLIPATFPEETVAQFGQDTPMGRPGQPVEHVGCYVLLASDESSYMTGQTL HVNGGNFVTT*" /label="ydaD CDS" gene 453276..454136 /gene="ydaD" /locus_tag="BSU_04190" /old_locus_tag="BSU04190" /label="ydaD gene" CDS 454152..454655 /gene="lyxE" /locus_tag="BSU_04200" /old_locus_tag="BSU04200" /EC_number="5.3.1.15" /experiment="publication(s) with functional evidences, PMID:10220166, 15805528, 21421786, 21520290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 15805528, 21421786, 21520290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-lyxose ketol isomerase" /protein_id="NP_388301.1" /db_xref="EnsemblGenomes-Gn:BSU04200" /db_xref="EnsemblGenomes-Tr:CAB12227" /db_xref="GOA:P96578" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="PDB:2Y0O" /db_xref="SubtiList:BG12053" /db_xref="UniProtKB/Swiss-Prot:P96578" /translation="MGITKEEVNSYYQKAGIVLTDEEVDQIQLMDYGLGKERKVGLQL FVYVNTDRYCSKELVLFPGQTCPEHRHPPVDGQEGKQETFRCRYGKVYLYVEGEKTPL PKVLPPQEDREHYTVWHEIELEPGGQYTIPPNTKHWFQAGEEGAVVTEMSSTSTDKHD IFTDPRI*" /label="lyxE CDS" gene 454152..454655 /gene="lyxE" /locus_tag="BSU_04200" /old_locus_tag="BSU04200" /label="lyxE gene" downshifts 454636 /Source="Nicolas_upshifts" /id="D191" /incds=0 /nref=16 /ntot=26 /MaxReadThrough="4.81615" /MaxDrop="6.21035" /score="29.8440619" /energy="-15.5" /TU="U325" /idTUdmin="U325" /TUdmin="-683" /isTUend="FALSE" /label="downshifts" promotor_-35 454684..454691 /Source="Nicolas_upshift_promotors" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 454705..454724 /Source="Nicolas_upshift_promotors" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 454707 /Source="Nicolas_upshifts" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="upshifts" CDS 454741..455292 /gene="ydaF" /locus_tag="BSU_04210" /old_locus_tag="BSU04210" /EC_number="2.3.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15468321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribosomal protein N-acetyltransferase" /protein_id="NP_388302.1" /db_xref="EnsemblGenomes-Gn:BSU04210" /db_xref="EnsemblGenomes-Tr:CAB12228" /db_xref="GOA:P96579" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1NSL" /db_xref="SubtiList:BG12054" /db_xref="UniProtKB/Swiss-Prot:P96579" /translation="MFTCKVNEHITIRLLEPKDAERLAELIIQNQQRLGKWLFFAENP SSADTYRETIIPDWRRQYADLNGIEAGLLYDGSLCGMISLHNLDQVNRKAEIGYWIAK EFEGKGIITAACRKLITYAFEELELNRVAICAAVGNEKSRAVPERIGFLEEGKARDGL YVNGMHHDLVYYSLLKREWEGEK*" /label="ydaF CDS" gene 454741..455292 /gene="ydaF" /locus_tag="BSU_04210" /old_locus_tag="BSU04210" /label="ydaF gene" promotor_-35 455307..455313 /Source="Nicolas_upshift_promotors" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 455328..455346 /Source="Nicolas_upshift_promotors" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 455341 /Source="Nicolas_upshifts" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="upshifts" CDS 455370..455792 /gene="ydaG" /locus_tag="BSU_04220" /old_locus_tag="BSU04220" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative general stress protein" /protein_id="NP_388303.1" /db_xref="EnsemblGenomes-Gn:BSU04220" /db_xref="EnsemblGenomes-Tr:CAB12229" /db_xref="GOA:P80238" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG19017" /db_xref="UniProtKB/Swiss-Prot:P80238" /translation="MNQQDIKQKVLDVLDHHKVGSLATVQKGKPHSRYMTFFHDGLTI YTPTSKETHKAEEIENNPNVHILLGYDCEGFGDAYVEVAGKAKINNSAELKDKIWSSK LERWFDGKDDPNLVILEIEPEDIRLMNAGEKTPVSLEL*" /label="ydaG CDS" gene 455370..455792 /gene="ydaG" /locus_tag="BSU_04220" /old_locus_tag="BSU04220" /label="ydaG gene" promotor_-35 455797..455805 /Source="Nicolas_upshift_promotors" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 455816..455835 /Source="Nicolas_upshift_promotors" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 455835..456201 /Source="Nicolas_S_feature" /locus_tag="new_474268_474634" /HighExp="Etha, Salt, Cold, Sw, B60, Gly, M9-stat, LPhT, B36, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigA" /TUshortPSig="0.993, 0.999, 1" /TUlongSig="SigB" /TUlongPSig=1 /label="S140" upshifts 455835 /Source="Nicolas_upshifts" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box complement(455861..455961) /Source="Nicolas_upshift_promotors" /id="U329" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.010989010989011" /xcortree=121 /SigmaFactorBS="aggggcgatttgttatgaaggaaaagaataagggcagctggt tatgctgcttgggaagcggtaagcttctctctcaaaacagaaaaaagaagtttacttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" misc_RNA complement(455896..456164) /gene="bsrC" /locus_tag="BSU_misc_RNA_64" /product="small regulatory RNA" /experiment="publication(s) with functional evidences, PMID:18948176, 23457461" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176, 23457461; Product type n: RNA" /label="bsrC RNA" gene complement(455896..456164) /gene="bsrC" /locus_tag="BSU_misc_RNA_64" /label="bsrC gene" upshifts complement(455901) /Source="Nicolas_upshifts" /id="U329" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.010989010989011" /xcortree=121 /SigmaFactorBS="aggggcgatttgttatgaaggaaaagaataagggcagctggt tatgctgcttgggaagcggtaagcttctctctcaaaacagaaaaaagaagtttacttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 456158 /Source="Nicolas_upshifts" /id="D192" /incds=0 /nref=124 /ntot=275 /MaxReadThrough="2.67264" /MaxDrop="7.35087" /score="29.9942993" /energy="-12" /TU="NA" /idTUdmin="U326" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-35 456238..456247 /Source="Nicolas_upshift_promotors" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 456260..456275 /Source="Nicolas_upshift_promotors" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 456265 /Source="Nicolas_upshifts" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="upshifts" CDS 456298..457107 /gene="amj" /locus_tag="BSU_04230" /old_locus_tag="BSU04230" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 25918422, 27537185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 25918422, 27537185; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipid II flippase" /protein_id="NP_388304.1" /db_xref="EnsemblGenomes-Gn:BSU04230" /db_xref="EnsemblGenomes-Tr:CAB12230" /db_xref="GOA:P96581" /db_xref="InterPro:IPR021260" /db_xref="SubtiList:BG12055" /db_xref="UniProtKB/Swiss-Prot:P96581" /translation="MHVITTQVLFIFCFLLLIHSIETLAYATRLSGARVGFIASALSL FNVMVIVSRMSNMVQQPFTGHLIDDAGKNALAIVGEQFRFLIFGSTVGTILGIILLPS FVALFSRAIIHLAGGGGSVFQVFRKGFSKQGFKNALSYLRLPSISYVKGFHMRLIPKR LFVINMLITSIYTIGVLSALYAGLLAPERSTTAVMASGLINGIATMLLAIFVDPKVSV LADDVAKGKRSYIYLKWTSVTMVTSRVAGTLLAQLMFIPGAYYIAWLTKWF*" /label="amj CDS" gene 456298..457107 /gene="amj" /locus_tag="BSU_04230" /old_locus_tag="BSU04230" /label="amj gene" downshifts 457088 /Source="Nicolas_upshifts" /id="D193" /incds=0 /nref=5 /ntot=103 /MaxReadThrough="2.92236" /MaxDrop="3.54247" /score="15.7032536" /energy="-14.9" /TU="U330" /idTUdmin="U327" /TUdmin=911 /isTUend="FALSE" /label="downshifts" CDS complement(457151..457441) /gene="ydzA" /locus_tag="BSU_04240" /old_locus_tag="BSU04240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388305.1" /db_xref="EnsemblGenomes-Gn:BSU04240" /db_xref="EnsemblGenomes-Tr:CAB12231" /db_xref="GOA:O31485" /db_xref="InterPro:IPR023845" /db_xref="SubtiList:BG12807" /db_xref="UniProtKB/Swiss-Prot:O31485" /translation="MLHTPIGRLRTMGFIEGMSLLILLFIAMPLKYWAGLPLAVTIVG SVHGGLFILYLLVLAYATFSVKWPLKWSAAGFIAAFVPFGNFLYDRGLRNYK*" /label="ydzA CDS" gene complement(457151..457441) /gene="ydzA" /locus_tag="BSU_04240" /old_locus_tag="BSU04240" /label="ydzA gene" downshifts complement(457155) /Source="Nicolas_upshifts" /id="D194" /incds=0 /nref=235 /ntot=260 /MaxReadThrough="1.23465" /MaxDrop="7.74945" /score="10.1798531" /energy="-14.9" /TU="NA" /idTUdmin="U332" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(457469..457488) /Source="Nicolas_upshift_promotors" /id="U332" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.653346653346653" /psig="0.967032967032967" /xcortree=1622 /SigmaFactorBS="catgtaaaaatgaatgttttccgaacattttttgaaagctgt catatgcccccccggATTGTTTATAGTATAAAATGaaaacgtgtccacaaggagggcg a" /listShort="ydzA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" misc_feature 457469..457487 /Source="Nicolas_upshift_promotors" /id="U331" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.691308691308691" /xcortree=306 /SigmaFactorBS="aagtcttccgatcggcgtgtgcagcataaatcgccctccttg tggacacgttttCATTTTATACTATAAACAAtccgggggggcatatgacagctttcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 457475 /Source="Nicolas_upshifts" /id="U331" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.691308691308691" /xcortree=306 /SigmaFactorBS="aagtcttccgatcggcgtgtgcagcataaatcgccctccttg tggacacgttttCATTTTATACTATAAACAAtccgggggggcatatgacagctttcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(457485) /Source="Nicolas_upshifts" /id="U332" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.653346653346653" /psig="0.967032967032967" /xcortree=1622 /SigmaFactorBS="catgtaaaaatgaatgttttccgaacattttttgaaagctgt catatgcccccccggATTGTTTATAGTATAAAATGaaaacgtgtccacaaggagggcg a" /listShort="ydzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 457563..457570 /Source="Nicolas_upshift_promotors" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 457584..457603 /Source="Nicolas_upshift_promotors" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 457588 /Source="Nicolas_upshifts" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="upshifts" CDS 457626..458060 /gene="lrpC" /locus_tag="BSU_04250" /old_locus_tag="BSU04250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9341680, 10606655, 10913073, 12458218, 16407330, 16528101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9341680, 10606655, 10913073, 12458218, 16407330, 16528101; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388306.1" /db_xref="EnsemblGenomes-Gn:BSU04250" /db_xref="EnsemblGenomes-Tr:CAB12232" /db_xref="GOA:P96582" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2CFX" /db_xref="SubtiList:BG12056" /db_xref="UniProtKB/Swiss-Prot:P96582" /translation="MKLDQIDLNIIEELKKDSRLSMRELGRKIKLSPPSVTERVRQLE SFGIIKQYTLEVDQKKLGLPVSCIVEATVKNADYERFKSYIQTLPNIEFCYRIAGAAC YMLKINAESLEAVEDFINKTSPYAQTVTHVIFSEIDTKNGRG*" /label="lrpC CDS" gene 457626..458060 /gene="lrpC" /locus_tag="BSU_04250" /old_locus_tag="BSU04250" /label="lrpC gene" promotor_-35 458057..458060 /Source="Nicolas_upshift_promotors" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 458069 /Source="Nicolas_upshifts" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 458077..458096 /Source="Nicolas_upshift_promotors" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 458125..460308 /gene="topB" /locus_tag="BSU_04260" /old_locus_tag="BSU04260" /EC_number="5.99.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16192570, 16556226; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA topoisomerase III" /protein_id="NP_388307.1" /db_xref="EnsemblGenomes-Gn:BSU04260" /db_xref="EnsemblGenomes-Tr:CAB12233" /db_xref="GOA:P96583" /db_xref="InterPro:IPR000380" /db_xref="InterPro:IPR003601" /db_xref="InterPro:IPR003602" /db_xref="InterPro:IPR005738" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013497" /db_xref="InterPro:IPR013825" /db_xref="InterPro:IPR023405" /db_xref="InterPro:IPR023406" /db_xref="InterPro:IPR034144" /db_xref="SubtiList:BG11979" /db_xref="UniProtKB/Swiss-Prot:P96583" /translation="MSKTVVLAEKPSVGRDLARVLKCHKKGNGYLEGDQYIVTWALGH LVTLADPEGYGKEFQSWRLEDLPIIPEPLKLVVIKKTGKQFNAVKSQLTRKDVNQIVI ATDAGREGELVARWIIEKANVRKPIKRLWISSVTDKAIKEGFQKLRSGKEYENLYHSA VARAEADWIVGINATRALTTKFNAQLSCGRVQTPTLAMIAKREADIQAFTPVPYYGIR AAVDGMTLTWQDKKSKQTRTFNQDVTSRLLKNLQGKQAVVAELKKTAKKSFAPALYDL TELQRDAHKRFGFSAKETLSVLQKLYEQHKLVTYPRTDSRFLSSDIVPTLKDRLEGME VKPYAQYVSQIKKRGIKSHKGYVNDAKVSDHHAIIPTEEPLVLSSLSDKERKLYDLIA KRFLAVLMPAFEYEETKVIAEIGGETFTAKGKTVQSQGWKAVYDMAEEDDEQEDDRDQ TLPALQKGDTLAVRTLTETSGQTKPPARFNEGTLLSAMENPSAFMQGEEKGLVKTLGE TGGLGTVATRADIIEKLFNSFLIEKKGQDIFITSKGKQLLQLVPEDLKSPALTAEWEQ KLSAIAAGKLKSAVFIKDMKAYAHQTVKEIKNSSQTFRHDNITGTACPECGKMMLKVN GKRGTMLVCQDRECGSRKTIARKTNARCPNCHKRMELRGQGEGQTFACVCGHREKLSV FEKRKNKDKARATKRDVSSYMKKQNKDEPINNALAEQLKKLGLDK*" /label="topB CDS" gene 458125..460308 /gene="topB" /locus_tag="BSU_04260" /old_locus_tag="BSU04260" /label="topB gene" downshifts 460291 /Source="Nicolas_upshifts" /id="D195" /incds=0 /nref=133 /ntot=245 /MaxReadThrough="3.22367" /MaxDrop="6.18597" /score="23.5229393" /energy="-10.4" /TU="U334" /idTUdmin="U333" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 460357..460363 /Source="Nicolas_upshift_promotors" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 460378..460396 /Source="Nicolas_upshift_promotors" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 460379..460510 /Source="Nicolas_S_feature" /locus_tag="new_478812_478943" /HighExp="Etha, Salt, Heat, Cold, H2O2, G180, LPhT, Oxctl, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="1, 0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S141" upshifts 460379 /Source="Nicolas_upshifts" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="upshifts" CDS 460511..461599 /gene="epsJ" /locus_tag="BSU_04270" /old_locus_tag="BSU04270" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15661000, 26078454, 27897378" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15661000, 26078454, 27897378; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="glycosyl hydrolase lipoprotein" /protein_id="NP_388308.1" /db_xref="EnsemblGenomes-Gn:BSU04270" /db_xref="EnsemblGenomes-Tr:CAB12234" /db_xref="GOA:O31486" /db_xref="InterPro:IPR008928" /db_xref="SubtiList:BG12057" /db_xref="UniProtKB/Swiss-Prot:O31486" /translation="MRHVLIAVILFFLSIGLSAGCAEAGNKTQNQSATEVNASPLQPA EYFIYHNLMNDKGLIKTDFSDQPSYLSESLGLWMEFLLSKNDAPHFQDQYQHLTDSFL MSNHLVTWKIQNGQASGTNALIDDMRIMLSLDQAAAKWGRSDYAQTARDIGTSLKTYN MNNGFFTDFYDSQAASKDVTLSYVMPDALAVLKKNGIIDEETEQRNANVLYSAPLKNG FLPKTYSSETKEYTYDSEINLIDQLYAAWHLPEGDEKASVLADWIKQEFQKNGKLYGR YSAYTKEPAVQYESPSVYALAVLFLTKQHENSSVIKAIYDRMNDFEIHDPVKSYYGGY MSGTQTHSFDNLLPLLAERKLFNENIIQ*" /label="epsJ CDS" gene 460511..461599 /gene="epsJ" /locus_tag="BSU_04270" /old_locus_tag="BSU04270" /label="epsJ gene" CDS 461580..462431 /gene="epsK" /locus_tag="BSU_04280" /old_locus_tag="BSU04280" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23893111, 27897378" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111, 27897378; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="cyclic-di-GMP receptor" /protein_id="NP_388309.1" /db_xref="EnsemblGenomes-Gn:BSU04280" /db_xref="EnsemblGenomes-Tr:CAB12235" /db_xref="GOA:P96585" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG12058" /db_xref="UniProtKB/Swiss-Prot:P96585" /translation="MKISFSESQKLFAYFSGLIAALSLFIYYVSAQQSEGALILCITF GVIAAGIWFGPIYALAVTLIVLFVLGTLMMFFQTGQTSLFPAEEGLRMLVVWGIALLL FSFISGRIHDITAELRRSMTRLQSEIKSYVAVDRVTGFDNKQRMKLELSEEIKRAERY GNSFVFLLLHMHYFKEFKSLYGEKETDRLFQYVGQQIRTSVRETDKKFRPSDERIGIV LTHTPAEHMPAVLTKLKKQLDTYQLENGKYVSLTFHVCYLPYRNDIQTADQFLEELEN EMMMNEL*" /label="epsK CDS" gene 461580..462431 /gene="epsK" /locus_tag="BSU_04280" /old_locus_tag="BSU04280" /label="epsK gene" CDS 462442..464151 /gene="ydaL" /locus_tag="BSU_04290" /old_locus_tag="BSU04290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27897378; Product type ph :phenotype" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388310.1" /db_xref="EnsemblGenomes-Gn:BSU04290" /db_xref="EnsemblGenomes-Tr:CAB12236" /db_xref="GOA:O31487" /db_xref="InterPro:IPR018763" /db_xref="SubtiList:BG12059" /db_xref="UniProtKB/Swiss-Prot:O31487" /translation="MLCVMMLLFSAIASFPVSAQAKDQDAGILIIYSTLDGKESSQVK MLDLLAGHFTSHVTVKKDSDVEASDFKGKDHVIYYGQTKRKLSQKLLSLISGVKKPVV AIGYNAGQISQFSGLSLARKENVFQVHSRSEKADVSLESGLNVLSVSGLKGTALYTFK ADEGTTHSFIWKTKKGNVYIGLTNLLNDNLIVAKQLREAFGEKAGTTLLYLRLEDISP MSDEKLLLQAGTYLHKRHIPFILAVIPVYLNPETGDKVYLSNQPKMVKVLKKLQSMGG SIIVHGYTHAYRYSETGEGFEFWDAKADQPITSGNAEDPPSILEKEQDFPNEQAYHSY LEPFREKEETYTKQKLTRAIEDLTSSGLYPLAFEAPHYTMSEYGYQIASQYFTSIFGQ VQLSSTTWKTSGAPPFVTAPSMLHGMTLYPETIGFVDTSKQNPLGEMEEHISQMIDFE GGVAGGFYHPYLGMKYLPELVDQMERIPDSEWLDLKKTKQTVKTDKVEIHTSGDGTIQ VKNGVSPIYEFFDHHRQTPLEKALWILSAVVLLFVIMFVSYTFYLRATLKKRIFKERR SLG*" /label="ydaL CDS" gene 462442..464151 /gene="ydaL" /locus_tag="BSU_04290" /old_locus_tag="BSU04290" /label="ydaL gene" CDS 464144..465406 /gene="ydaM" /locus_tag="BSU_04300" /old_locus_tag="BSU04300" /EC_number="2.4.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27897378, 28296273; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase associated to biofilm formation" /protein_id="NP_388311.1" /db_xref="EnsemblGenomes-Gn:BSU04300" /db_xref="EnsemblGenomes-Tr:CAB12237" /db_xref="GOA:P96587" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12060" /db_xref="UniProtKB/Swiss-Prot:P96587" /translation="MGNTLFFISLSLIWVMLLYHMFLMQGGFRHYMTFERNIPKWREN MKELPKVSVLIPAHNEEVVIRQTLKAMVNLYYPKDRLEIIVVNDNSSDRTGDIVNEFS EKYDFIKMVITKPPNAGKGKSSALNSGFAESNGDVICVYDADNTPEKMAVYYLVLGLM NDEKAGAVVGKFRVINAAKTLLTRFINIETICFQWMAQGGRWKWFKIATIPGTNFAIR RSIIEKLGGWDDKALAEDTELTIRVYNLGYHIRFFPAAITWEQEPETWKVWWRQRTRW ARGNQYVVLKFLAQFFKLKRKRIIFDLFYFFFTYFLFFFGVIMSNAIFVVNLFYDLHL SVGFLAMILWILAFFLFMTEVMITLSIEKTEMNKQNFFIVFLMYFTYSQAWIVLVIYS LFVEIKHRLFKQEVKWYKTERYNQHKSG*" /label="ydaM CDS" gene 464144..465406 /gene="ydaM" /locus_tag="BSU_04300" /old_locus_tag="BSU04300" /label="ydaM gene" CDS 465412..467523 /gene="ydaN" /locus_tag="BSU_04310" /old_locus_tag="BSU04310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27897378; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative regulator of exopolysaccharide synthesis" /protein_id="NP_388312.1" /db_xref="EnsemblGenomes-Gn:BSU04310" /db_xref="EnsemblGenomes-Tr:CAB12238" /db_xref="GOA:O31488" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR018513" /db_xref="SubtiList:BG12061" /db_xref="UniProtKB/Swiss-Prot:O31488" /translation="MKQIMIFLTSFMLLAMTGQTALAKDVQVSGSLLGKSSQEQAKQQ VLTSELITLYGSKDSAELTYQIPAGASSGNQQLVIEYEASNLLISPSSLTVVIDDEPV KTLKLDGDSKRKTVKLNLNKSQSAQGYHNVSLKFYGVMKEGVCVRQDTSGNWIKIYPD SRLTLADSSEAKGTSLDHYPYPFAQSGNTAEETAIVIPDNPSSAEIEAAVKTEGYLKT VDSSVSIAYVTESELKKIDKPTIVIGVDKHWNGKVKKLLKQAGLQAKGENLLLAERVL KAEGKQQPVLFAQAASEDALTKKISVMTDQTYTGQLSGDTLSISKLQQTEKKESDKLT LENFGAGDITIGADKTSSAHYFYPASAVLDENQSAKLSLKLKKSETIQASTAENESAS QAAELKVMINGQPHSVRLDELGKEDKNGFYHVTVKVDPKLLQKNRYIDIQFVTTGLKE NNPCNTTDEEKWVFIDKNSTLSYAIKGMSPSADFQEWPLPYAGNQDQTTLIVLPDTVS QSKLEELSLVTESFGNEAQHSYTVKKSSDVTANDAKGRNLIFIGGINQFSLLKEKSSD LLVPQEKNGSFDVSSFEMLNETTKQVVFTQASVWDSRYTMAVFAPSKGDGTAVTKEII SYLNSNDESATVLNETNSQQVFTNHQQLKSETNSSDAEQPTQDHSQKWMYIGVLALIM VVAAVFIWIAVRRKKRKTDTE*" /label="ydaN CDS" gene 465412..467523 /gene="ydaN" /locus_tag="BSU_04310" /old_locus_tag="BSU04310" /label="ydaN gene" downshifts 467507 /Source="Nicolas_upshifts" /id="D196" /incds=0 /nref=18 /ntot=91 /MaxReadThrough="0.438479999999999" /MaxDrop="4.36576" /score="34.1370207" /energy="-9.9" /TU="NA" /idTUdmin="U336" /TUdmin="-4598" /isTUend="FALSE" /label="downshifts" promotor_-35 467620..467627 /Source="Nicolas_upshift_promotors" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 467642..467661 /Source="Nicolas_upshift_promotors" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 467649 /Source="Nicolas_upshifts" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 467659..467802 /gene="swaO" /locus_tag="BSU_misc_RNA_7" /product="ATP-, cyclic di-AMP-sensing riboswitch" /experiment="publication(s) with functional evidences, PMID:15096624, 20511502, 23086297, 25086507, 25086509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 20511502, 23086297, 25086507, 25086509; Product type n: RNA" /function="16.3: Control" /label="swaO RNA" gene 467659..467802 /gene="swaO" /locus_tag="BSU_misc_RNA_7" /label="swaO gene" downshifts 467800 /Source="Nicolas_upshifts" /id="D197" /incds=0 /nref=10 /ntot=52 /MaxReadThrough="7.43698" /MaxDrop="5.83561" /score="30.4392599" /energy="-14.7" /TU="U336" /idTUdmin="U336" /TUdmin="-4305" /isTUend="FALSE" /label="downshifts" S_feature 467845..467998 /Source="Nicolas_S_feature" /locus_tag="new_486278_486431" /HighExp="LPhT, LBGstat, LPh, T-1.10H, T-0.40H, G135, G180, T-1.40H, G150, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S142" CDS 467999..469822 /gene="kimA" /locus_tag="BSU_04320" /old_locus_tag="BSU04320" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15096624, 15849754, 16850406, 20511502, 25086509, 26789423, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 15849754, 16850406, 20511502, 25086509, 26789423, 28420751; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cyclic di-AMP controlled transporter of potassium" /protein_id="NP_388313.1" /db_xref="EnsemblGenomes-Gn:BSU04320" /db_xref="EnsemblGenomes-Tr:CAB12239" /db_xref="GOA:P96589" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12062" /db_xref="UniProtKB/Swiss-Prot:P96589" /translation="MYHSIKRFLIGKPLKSQAAGEQKLTKLKALAMLSSDALSSVAYG TEQILIILATISAAAFWYSIPIAVGVLILLLALILSYRQIIYAYPQGGGAYIVSKENL GEKPGLIAGGSLLVDYILTVAVSISAGTDAITSAFPALHDYHVPIAIFLVLVIMILNL RGLSESASILAYPVYLFVVALLVLIAVGLFKLMTGQIDQPAHHTSLGTPVAGITLFLL LKAFSSGCSALTGVEAISNAIPAFKNPPARNAARTLAMMGILLAILFSGITVLAYGYG TAPKPDETVVSQIASETFGRNVFYYVIQGVTSLILVLAANTGFSAFPQLAFNLARDQY MPRMFTVRGDRLGFSNGIIFLGFASIVLIILFGGQTEHLIPLYAVGVFIPFTLSQTGM CMKWIKQKPKGWIGKMLINSCGALISFMVLSILFVTKFNVVWPVLIFMPIVVLLFFAI KNHYTAVGEQLRIVDKEPEEIKGTVVIVPVAGVTTVVQKSIHYAKSLSDQVIAVHVSF DREQEKKFEKRWEELNNGVRLVTLHSSYRSLVHPFDKFLETVEAKAKKEQFSVMVLFP QFITKKRWHTILHNQSAFLLRVRLFWKKDIMVATLPYHFKK*" /label="kimA CDS" gene 467999..469822 /gene="kimA" /locus_tag="BSU_04320" /old_locus_tag="BSU04320" /label="kimA gene" downshifts 469814 /Source="Nicolas_upshifts" /id="D198" /incds=0 /nref=50 /ntot=181 /MaxReadThrough="3.55206" /MaxDrop="4.7232" /score="6.00201196" /energy="-13.9" /TU="U336" /idTUdmin="U336" /TUdmin="-2291" /isTUend="FALSE" /label="downshifts" CDS 469881..470330 /gene="nudT" /locus_tag="BSU_04330" /old_locus_tag="BSU04330" /EC_number="3.6.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15576788, 16513759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NTP pyrophosphohydrolase" /protein_id="NP_388314.1" /db_xref="EnsemblGenomes-Gn:BSU04330" /db_xref="EnsemblGenomes-Tr:CAB12240" /db_xref="GOA:P96590" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG11956" /db_xref="UniProtKB/Swiss-Prot:P96590" /translation="MYTQGAFVIVLNESQQILLVKRKDVPLWDLPGGRVDPGESAEEA AVREILEETGYNAALSAKIGVYQRPKFQDEQHLFFGSITGGQAMADGTETAGLKWVSP GRLPLFMVPNRKRQINDFKNGAQDVNVTVKDSGLLAAIDLLKRRLGK*" /label="nudT CDS" gene 469881..470330 /gene="nudT" /locus_tag="BSU_04330" /old_locus_tag="BSU04330" /label="nudT gene" promotor_-35 470343..470349 /Source="Nicolas_upshift_promotors" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 470364..470382 /Source="Nicolas_upshift_promotors" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 470365 /Source="Nicolas_upshifts" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="upshifts" CDS 470397..472121 /gene="poxB" /locus_tag="BSU_04340" /old_locus_tag="BSU04340" /EC_number="1.2.3.3" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16291680, 16513748, 10220166, 23611909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-phosphate generating pyruvate oxidase" /protein_id="NP_388315.1" /db_xref="EnsemblGenomes-Gn:BSU04340" /db_xref="EnsemblGenomes-Tr:CAB12241" /db_xref="GOA:P96591" /db_xref="InterPro:IPR000399" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG12063" /db_xref="UniProtKB/Swiss-Prot:P96591" /translation="MAHKTAGQAMTELLEQWGVDHVYGIPGDSINEFIEELRHERNQL KFIQTRHEEVAALAAAAEAKLTGKIGVCLSIAGPGAVHLLNGLYDAKADGAPVLAIAG QVSSGEVGRDYFQEIKLEQMFEDVAVFNREVHSAESLPDLLNQAIRTAYSKKGVAVLS VSDDLFAEKIKREPVYTSPVYIEGNLEPKKEQLVTCAQYINNAKKPIILAGQGMKKAK RELLEFADKAAAPIVVTLPAKGVVPDKHPHFLGNLGQIGTKPAYEAMEECDLLIMLGT SFPYRDYLPDDTPAIQLDSDPAKIGKRYPVTAGLVCDSALGLRELTEYIERKEDRRFL NACTEHMQHWWNEIEKDETEATTPLKPQQVVARLQEAAADDAVLSVDVGTVTVWMARH FKMNANQDFIVSSWLATMGCGLPGAIAASLSEPERQAIAVCGDGGFSMVMQDLPTAVK YKLPITVVILNNENLGMIEYEQQVKGNIDYVTKLQNVDYAAFAESCGAKGIKVTKAEE LAPAFHEALHSDQPVVVDVMIGNEPPLPGKITYGQAKGFSKYMLKNFFENQKFEMPSL KKSLKRLF*" /label="poxB CDS" gene 470397..472121 /gene="poxB" /locus_tag="BSU_04340" /old_locus_tag="BSU04340" /label="poxB gene" S_feature complement(471233..472092) /Source="Nicolas_S_feature" /locus_tag="new_489666_490525_c" /HighExp="H2O2, Paraq, G180, G150, Oxctl, Diami, dia15, G135, C30, dia5" /AntisenseName="ydaP" /AntisenseCor="-5.0529608261635599E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.113, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S143" S_feature complement(472094..472205) /Source="Nicolas_S_feature" /locus_tag="new_490527_490638_c" /HighExp="dia5, M0t45, S0, S2, S1, Paraq, GM 120, Lbstat, MG 5, UNK1" /AntisenseName="ydaP" /AntisenseCor="1.7026698118644101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.113, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S144" downshifts 472105 /Source="Nicolas_upshifts" /id="D199" /incds=0 /nref=50 /ntot=166 /MaxReadThrough="5.18566" /MaxDrop="6.66568" /score="7.55338633" /energy="-5.3" /TU="U337" /idTUdmin="U336" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(472113..472316) /locus_tag="BSU_04345" /old_locus_tag="BSU04345" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513943.1" /translation="MIRISMQGQMHLPLKQDAFVLLSVSSMAKSVPNTYTDHFMNSNM LKIHLFPKKKKKTRALRAPVFLK*" /label="hypothetical protein CDS" gene complement(472113..472316) /locus_tag="BSU_04345" /old_locus_tag="BSU04345" /label="gene" downshifts complement(472137) /Source="Nicolas_upshifts" /id="D200" /incds=0 /nref=5 /ntot=55 /MaxReadThrough="4.75809" /MaxDrop="8.06239" /score="11.2659249" /energy="-9.1" /TU="U338,U340,U341" /idTUdmin="U338" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" promotor_no_box complement(472165..472265) /Source="Nicolas_upshift_promotors" /id="U338" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.445554445554446" /psig="0.112887112887113" /xcortree=1496 /SigmaFactorBS="gcatttgtccttttgtctgtttcgagtatggcgaaatcagtt cctaatacatataccgatcattttatgaattcaaacatgctgaaaatacatttgtttc c" /listShort="S144, S143" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-35 472174..472179 /Source="Nicolas_upshift_promotors" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 472196..472214 /Source="Nicolas_upshift_promotors" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(472205) /Source="Nicolas_upshifts" /id="U338" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.445554445554446" /psig="0.112887112887113" /xcortree=1496 /SigmaFactorBS="gcatttgtccttttgtctgtttcgagtatggcgaaatcagtt cctaatacatataccgatcattttatgaattcaaacatgctgaaaatacatttgtttc c" /listShort="S144, S143" /GFF_Attribute="listLong" /label="upshifts" S_feature 472206..472421 /Source="Nicolas_S_feature" /locus_tag="new_490639_490854" /HighExp="Etha, S4, S8, S5, C30, S7, B60, S6, Salt, B36" /AntisenseName="ydzK" /AntisenseCor="3.8830946787094797E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigB" /TUshortPSig="0.914, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S145" upshifts 472206 /Source="Nicolas_upshifts" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(472272..472343) /Source="Nicolas_S_feature" /locus_tag="new_490705_490776_c" /HighExp="Sw, B60, dia15, dia5, BI, Etha, BC, M9-stat, C90, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S146" downshifts complement(472315) /Source="Nicolas_upshifts" /id="D201" /incds=0 /nref=21 /ntot=191 /MaxReadThrough="5.39949" /MaxDrop="5.81865" /score="3.34912028" /energy="-20.3" /TU="U340,U341" /idTUdmin="U343" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(472344..472610) /gene="ydzK" /locus_tag="BSU_04359" /old_locus_tag="BSU04359" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="YP_003097680.1" /db_xref="EnsemblGenomes-Gn:BSU04359" /db_xref="EnsemblGenomes-Tr:CAX52551" /db_xref="GOA:C0H3V4" /db_xref="UniProtKB/Swiss-Prot:C0H3V4" /translation="MSVFILFYLWIVPIVIGILCSVAAHKSKGKMRVAPGIAMIVLSI ISLITAFTAGHTNFHVFIGGMFLFGTFLVGSAFPFFFGLKKKEK*" /label="ydzK CDS" gene complement(472344..472610) /gene="ydzK" /locus_tag="BSU_04359" /old_locus_tag="BSU04359" /label="ydzK gene" promotor_-10 complement(472626..472645) /Source="Nicolas_upshift_promotors" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(472644) /Source="Nicolas_upshifts" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(472657..472664) /Source="Nicolas_upshift_promotors" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(472714..473991) /gene="mntH" /locus_tag="BSU_04360" /old_locus_tag="BSU04360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12029030, 12950915, 14580210, 15849754, 16850406, 27573840, 27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029030, 12950915, 14580210, 15849754, 16850406, 27573840, 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton-coupled manganese transporter" /protein_id="NP_388317.1" /db_xref="EnsemblGenomes-Gn:BSU04360" /db_xref="EnsemblGenomes-Tr:CAB12243" /db_xref="GOA:P96593" /db_xref="InterPro:IPR001046" /db_xref="SubtiList:BG12065" /db_xref="UniProtKB/Swiss-Prot:P96593" /translation="MMNKDITAQSPRSKAVQDALDGKIRGFRGLLPFLGPAFIAAIAY IDPGNFATNISAGSKYGYMLLWVILFSNIMALLIQSLSAKLGIATGKNLPEVAREEFP KPVSIGLWIQGELVIIATDLAEFIGAALGLYLLFGIPMLEASIIAAIGSFAILELQRR GYRSLEAGIAGMLFVVVIAFALQTFFAKPDAVSVMKGLFVPAFHGTDSVLLAAGILGA TVMPHAIYLHSALTQRRVVGKTDAERKKIFRFEFIDILIAMLIAGAINASMLIVAAAL FFKNGLFVEDLDVAFQQFGHLVSPMSAALFGIGLLVAGLSSSSVGTLSGDVIMQGFIN YRIPLYVRRFITIIPPILIIASGVNPTTALVLSQVVLSFGIAFALIPLIMFTSNKRIM GSLINAKWITVVSWLIAVLIVALNVFLIVDTFR*" /label="mntH CDS" gene complement(472714..473991) /gene="mntH" /locus_tag="BSU_04360" /old_locus_tag="BSU04360" /label="mntH gene" downshifts complement(472733) /Source="Nicolas_upshifts" /id="D202" /incds=0 /nref=170 /ntot=242 /MaxReadThrough="5.8826" /MaxDrop="4.8109" /score="28.3182556" /energy="-9.6" /TU="U341,U343" /idTUdmin="U342" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(474053..474072) /Source="Nicolas_upshift_promotors" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(474065) /Source="Nicolas_upshifts" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(474067..474144) /Source="Nicolas_S_feature" /locus_tag="new_492500_492577_c" /HighExp="S6, S8, S7, Etha, S5, Salt, BT, Heat, B36, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB" /TUshortPSig="1, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S147" promotor_-35 complement(474085..474092) /Source="Nicolas_upshift_promotors" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(474128..474147) /Source="Nicolas_upshift_promotors" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(474144) /Source="Nicolas_upshifts" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(474161..474170) /Source="Nicolas_upshift_promotors" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(474221..474478) /gene="ydaS" /locus_tag="BSU_04370" /old_locus_tag="BSU04370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388318.1" /db_xref="EnsemblGenomes-Gn:BSU04370" /db_xref="EnsemblGenomes-Tr:CAB12244" /db_xref="GOA:P96594" /db_xref="InterPro:IPR007341" /db_xref="SubtiList:BG12066" /db_xref="UniProtKB/Swiss-Prot:P96594" /translation="MLSFLVSLVVAIVIGLIGSAIVGNRLPGGIFGSMIAGLIGAWIG HGLLGTWGPSLAGFAIFPAIIGAAIFVFLLGLIFRGLRKEA*" /label="ydaS CDS" gene complement(474221..474478) /gene="ydaS" /locus_tag="BSU_04370" /old_locus_tag="BSU04370" /label="ydaS gene" downshifts complement(474229) /Source="Nicolas_upshifts" /id="D203" /incds=0 /nref=7 /ntot=33 /MaxReadThrough="4.70076" /MaxDrop="4.7213" /score="7.04635537" /energy="-13.4" /TU="U343" /idTUdmin="U342" /TUdmin="-1496" /isTUend="FALSE" /label="downshifts" downshifts complement(474295) /Source="Nicolas_upshifts" /id="D204" /incds=1 /nref=2 /ntot=69 /MaxReadThrough="7.55545" /MaxDrop="2.8244" /score="7.04635537" /energy="-13.4" /TU="U343" /idTUdmin="U342" /TUdmin="-1562" /isTUend="FALSE" /label="downshifts" CDS complement(474556..475008) /gene="ydaT" /locus_tag="BSU_04380" /old_locus_tag="BSU04380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388319.1" /db_xref="EnsemblGenomes-Gn:BSU04380" /db_xref="EnsemblGenomes-Tr:CAB12245" /db_xref="InterPro:IPR018691" /db_xref="SubtiList:BG12067" /db_xref="UniProtKB/Swiss-Prot:P96595" /translation="MPWSMKDYPASLKNLEKPVRKKAIDIANAMIDEGYEEGRAIPIA TSKAKEWAENASTDEIDDFLTHDDETERDADPSSGSGPELMNKAEHVIKHKKGWAVKA EGAKRVSEIKDTKKEAIERAKEIAAHKGTEVIVHLADGSVQRKIKTGS*" /label="ydaT CDS" gene complement(474556..475008) /gene="ydaT" /locus_tag="BSU_04380" /old_locus_tag="BSU04380" /label="ydaT gene" promotor_-10 complement(475027..475045) /Source="Nicolas_upshift_promotors" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(475044) /Source="Nicolas_upshifts" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(475059..475065) /Source="Nicolas_upshift_promotors" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 475077 /Source="Nicolas_upshifts" /id="U344" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.795204795204795" /psig="0.993006993006993" /xcortree=2375 /SigmaFactorBS="ctccttttccttttataaaaatggtacccgcaggtgaaaaat aaaaacgcatccgaaaaaatgaaggtATACTATATAGTAGAAAAAAcggaagggaagt g" /listShort="ydbA" /GFF_Attribute="listLong" /label="upshifts" misc_feature 475085..475104 /Source="Nicolas_upshift_promotors" /id="U344" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.795204795204795" /psig="0.993006993006993" /xcortree=2375 /SigmaFactorBS="ctccttttccttttataaaaatggtacccgcaggtgaaaaat aaaaacgcatccgaaaaaatgaaggtATACTATATAGTAGAAAAAAcggaagggaagt g" /listShort="ydbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 475126..475944 /gene="ydbA" /locus_tag="BSU_04390" /old_locus_tag="BSU04390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388320.1" /db_xref="EnsemblGenomes-Gn:BSU04390" /db_xref="EnsemblGenomes-Tr:CAB12246" /db_xref="InterPro:IPR024787" /db_xref="SubtiList:BG12068" /db_xref="UniProtKB/Swiss-Prot:P96596" /translation="MPTERKEDLHQQLKEIEKWEKDQQKVWFWEKLSRLPFQLLDKLT PEFIQKKIGKLLDEVGSFVQTGGQYLTSEKQIIRMFQKKLPEEIFESLEDIRKAPLPV MDEIAEGMGKNRTNAATVQGATTGVGGVFTLAADIPAVLGLSLKTLQDIAVAYGYDPK EKKERVFIVKCLQLTSADVVGKRSILQELKHYDQDRTYKNVASQIQGWREVVLGYRDT FGWKKLFQIVPVAGMVFGAAANRSTLNDITETGMMLYKKRRILERLKETEREME*" /label="ydbA CDS" gene 475126..475944 /gene="ydbA" /locus_tag="BSU_04390" /old_locus_tag="BSU04390" /label="ydbA gene" downshifts 475935 /Source="Nicolas_upshifts" /id="D205" /incds=0 /nref=118 /ntot=223 /MaxReadThrough="0.66117" /MaxDrop="4.41502" /score="5.38936313" /energy="-9.2" /TU="NA" /idTUdmin="U344" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 476012..476018 /Source="Nicolas_upshift_promotors" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 476032..476050 /Source="Nicolas_upshift_promotors" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 476040 /Source="Nicolas_upshifts" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="upshifts" CDS 476073..476444 /gene="gsiB" /locus_tag="BSU_04400" /old_locus_tag="BSU04400" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7651322, 9669336, 9763714, 12562800, 21421783" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7651322, 9669336, 9763714, 12562800, 21421783; Product type f: factor" /codon_start=1 /transl_table=11 /product="general stress protein glucose starvation induced" /protein_id="NP_388321.1" /db_xref="EnsemblGenomes-Gn:BSU04400" /db_xref="EnsemblGenomes-Tr:CAB12247" /db_xref="InterPro:IPR019626" /db_xref="SubtiList:BG10826" /db_xref="UniProtKB/Swiss-Prot:P26907" /translation="MADNNKMSREEAGRKGGETTSKNHDKEFYQEIGQKGGEATSKNH DKEFYQEIGEKGGEATSKNHDKEFYQEIGEKGGEATSENHDKEFYQEIGRKGGEATSK NHDKEFYQEIGSKGGNARNND*" /label="gsiB CDS" gene 476073..476444 /gene="gsiB" /locus_tag="BSU_04400" /old_locus_tag="BSU04400" /label="gsiB gene" downshifts complement(476077) /Source="Nicolas_upshifts" /id="D206" /incds=0 /nref=1 /ntot=25 /MaxReadThrough="1.50212" /MaxDrop="4.6705" /score="-7.76438364" /energy="-14.2" /TU="NA" /idTUdmin="U346" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 476461 /Source="Nicolas_upshifts" /id="D207" /incds=0 /nref=153 /ntot=219 /MaxReadThrough="3.75525" /MaxDrop="8.3301" /score="39.7307477" /energy="-16.6" /TU="U345" /idTUdmin="U345" /TUdmin="-24" /isTUend="FALSE" /label="downshifts" upshifts complement(476495) /Source="Nicolas_upshifts" /id="U346" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.00899100899100899" /xcortree=120 /SigmaFactorBS="cttattgtatctcaatagcggcataaattgagaagattccaa aaaaaagcgatcCAGCtgatgtgccggatcgcttttttatttacaggttgtctgcctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(476498..476501) /Source="Nicolas_upshift_promotors" /id="U346" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.00899100899100899" /xcortree=120 /SigmaFactorBS="cttattgtatctcaatagcggcataaattgagaagattccaa aaaaaagcgatcCAGCtgatgtgccggatcgcttttttatttacaggttgtctgcctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 476523..476530 /Source="Nicolas_upshift_promotors" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 476542..476561 /Source="Nicolas_upshift_promotors" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 476549 /Source="Nicolas_upshifts" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="upshifts" CDS 476576..476917 /gene="ydbB" /locus_tag="BSU_04410" /old_locus_tag="BSU04410" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme; cupin family" /protein_id="NP_388322.1" /db_xref="EnsemblGenomes-Gn:BSU04410" /db_xref="EnsemblGenomes-Tr:CAB12248" /db_xref="GOA:P96597" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR019780" /db_xref="SubtiList:BG12069" /db_xref="UniProtKB/Swiss-Prot:P96597" /translation="MSKMQNLLAIANEVKEKHANFSISEVNDHCVRLAVFTGEYDWHH HPDSDELFIVLEGELLIDFKDKETAVLKANDSLLIPKGTVHRTRSYVRTVNLCVEHKQ AETVIIEEQPC*" /label="ydbB CDS" gene 476576..476917 /gene="ydbB" /locus_tag="BSU_04410" /old_locus_tag="BSU04410" /label="ydbB gene" CDS 476911..477270 /gene="ydbC" /locus_tag="BSU_04420" /old_locus_tag="BSU04420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388323.1" /db_xref="EnsemblGenomes-Gn:BSU04420" /db_xref="EnsemblGenomes-Tr:CAB12249" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR032555" /db_xref="SubtiList:BG12070" /db_xref="UniProtKB/Swiss-Prot:P96598" /translation="MLIKKMICEVDAANAEAFAKAQSQWEALSHISGFIKQAGGWRKT IDEPLTAEIISVWENREAYDHFMENEHDSIYEENDQKAVILSIEVTVYEEDKPFVHDL LHNPDIRYEPNWTVLKA*" /label="ydbC CDS" gene 476911..477270 /gene="ydbC" /locus_tag="BSU_04420" /old_locus_tag="BSU04420" /label="ydbC gene" S_feature complement(476973..477266) /Source="Nicolas_S_feature" /locus_tag="new_495406_495699_c" /HighExp="Etha, Salt, M9-stat, C30, Heat, Sw, B60, S8, C90, UNK1" /AntisenseName="ydbC" /AntisenseCor="0.16172626521480701" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S148" downshifts 477211 /Source="Nicolas_upshifts" /id="D208" /incds=0 /nref=2 /ntot=130 /MaxReadThrough="1.8663" /MaxDrop="2.67081" /score="39.7307477" /energy="-16.6" /TU="NA" /idTUdmin="U347" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 477255 /Source="Nicolas_upshifts" /id="D209" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="0.252220000000001" /MaxDrop="2.61185" /score="39.7307477" /energy="-16.6" /TU="NA" /idTUdmin="U347" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(477307..478128) /gene="ydbD" /locus_tag="BSU_04430" /old_locus_tag="BSU04430" /EC_number="1.11.1.6" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15231799; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative manganese-containing catalase" /protein_id="NP_388324.1" /db_xref="EnsemblGenomes-Gn:BSU04430" /db_xref="EnsemblGenomes-Tr:CAB12250" /db_xref="GOA:P80878" /db_xref="InterPro:IPR007760" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR027407" /db_xref="SubtiList:BG12071" /db_xref="UniProtKB/Swiss-Prot:P80878" /translation="MFKHTKMLQHPAKPDRPDPLFAKKMQEILGGQFGEISVAMQYLF QGWNTRGNEKYKDLLMDTATEELGHVEMIATMIARLLEDAPLDQQEKAAEDPVIGSIL GGMNPHHAIVSGLGAMPESSTGVPWSGGYIVASGNLLADFRANLNAESQGRLQVARLF EMTDDKGVKDMLSFLLARDTMHQNQWLAAIKELEAQEGPVVPGTFPKALEKQEFSHQL INFSEGEVSAEQNWLNEKAPDGEAFEYVKEAKTFGEKPELKPAPPFVHNTLPGRE*" /label="ydbD CDS" gene complement(477307..478128) /gene="ydbD" /locus_tag="BSU_04430" /old_locus_tag="BSU04430" /label="ydbD gene" downshifts complement(477311) /Source="Nicolas_upshifts" /id="D210" /incds=0 /nref=62 /ntot=214 /MaxReadThrough="4.23505" /MaxDrop="6.82771" /score="-6.55917314" /energy="-13.1" /TU="U348" /idTUdmin="U348" /TUdmin="-310" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(478150..478168) /Source="Nicolas_upshift_promotors" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(478171) /Source="Nicolas_upshifts" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(478182..478188) /Source="Nicolas_upshift_promotors" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(478213..479265) /gene="dctB" /locus_tag="BSU_04440" /old_locus_tag="BSU04440" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:1809844, 10708364, 11566984, 24375102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1809844, 10708364, 11566984, 24375102; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="membrane bound C4-dicarboxylate binding sensor protein" /protein_id="NP_388325.1" /db_xref="EnsemblGenomes-Gn:BSU04440" /db_xref="EnsemblGenomes-Tr:CAB12251" /db_xref="GOA:P96600" /db_xref="InterPro:IPR004682" /db_xref="InterPro:IPR018389" /db_xref="SubtiList:BG12072" /db_xref="UniProtKB/Swiss-Prot:P96600" /translation="MKSLLACLALMIAGIATALFIGFHDHTGNKKIVYDDDQEGLQDQ IVFKFSHVVAENTPKGLAANKFADLVNEKSGGKIKIEVFPNGSLYSDIEEIEALQNGD VQFIAPSTSKLGMLSPEWGVLDLPYAFTDYNAVKKGLNGSIGTQLFDSLKKNQLKGLA YWTNGFKQITTNQGPVKTPDDLKGQDLRIMQSDVIEDQFKLLGATPHQESFNSTFQLL ENNVVDGEENTISNIYSKKFYNVQDYLTISSHGYLGYAVMTDEHFWKAQTPETRRILT EAMKETTEWNETYAEQMNKEQLEEIKKNSAIHIYELSDKEKQEWMKRLDPVYRQYEPI FGRELIRELLELRKDS*" /label="dctB CDS" gene complement(478213..479265) /gene="dctB" /locus_tag="BSU_04440" /old_locus_tag="BSU04440" /label="dctB gene" promotor_-35 478525..478532 /Source="Nicolas_upshift_promotors" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 478547..479334 /Source="Nicolas_S_feature" /locus_tag="new_496980_497767" /HighExp="LBGstat, Diami, T-0.40H, T0.0H, T0.30H, Heat, UNK1, GM-0.1, MG 90, Fru" /AntisenseName="dctB" /AntisenseCor="0.64205060306327899" /AntisenseRegPval="-31.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S149" promotor_-10 478547..478566 /Source="Nicolas_upshift_promotors" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 478548 /Source="Nicolas_upshifts" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(479278..479297) /Source="Nicolas_upshift_promotors" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(479283) /Source="Nicolas_upshifts" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(479311..479318) /Source="Nicolas_upshift_promotors" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 479335..480942 /gene="dctS" /locus_tag="BSU_04450" /old_locus_tag="BSU04450" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10627041, 11717295, 1290636, 12949159, 24375102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 11717295, 1290636, 12949159, 24375102; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_388326.1" /db_xref="EnsemblGenomes-Gn:BSU04450" /db_xref="EnsemblGenomes-Tr:CAB12252" /db_xref="GOA:P96601" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12073" /db_xref="UniProtKB/Swiss-Prot:P96601" /translation="MNKKKLSIRWKITILSYILVIFSFLIGGIVLIGNIQHTEERELK KRLMNTARTVSEMTEVKEALARKKQTEAVRHAVEEIRMINEADYIVVMDMNHIRYTHP VSTSIGKKSEGADEEAAFAEHIYFSEAKGEIGTAVRAFYPVKDQDLNQIGVVLVGKTL PGIADILLHLKRDIAFIVVLTLGFGLAGSFLLARHIKKQMFQLEPHEIVRMYEERTAT FHSMNEGVIAIDNRLVITIFNEKAKQIFEVQGDLIGKVIWEVLKDSRLPEIVERNKAV YNEEIRVSGKVIMSSRIPIVMKKKVIGAVAIFQDRTEAAKMAEELTGVRNFVEALRVQ NHEHMNKLHTIAGLIQLGKSEKALQLAFQASTEQENVTEFLHRSIQNDAAAGLLLSKI RRGRELGIAVHIDENSSLQQFPEHVDQHDIVVLLGNLIENAFGSFETVQSEDKRIDIS IEQTDDILAILIEDNGCGIEPTHMPRLYDKGFTVNKTGGTGYGLYLVKQIIDKGSGTI EVDSHAGQGTSFSIVFPMKGEEAQHGS*" /label="dctS CDS" gene 479335..480942 /gene="dctS" /locus_tag="BSU_04450" /old_locus_tag="BSU04450" /label="dctS gene" CDS 480932..481612 /gene="dctR" /locus_tag="BSU_04460" /old_locus_tag="BSU04460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10627041, 11717295, 1290636, 12949159" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 11717295, 1290636, 12949159; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_388327.1" /db_xref="EnsemblGenomes-Gn:BSU04460" /db_xref="EnsemblGenomes-Tr:CAB12253" /db_xref="GOA:P96602" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12074" /db_xref="UniProtKB/Swiss-Prot:P96602" /translation="MARKEWKVLLIEDDPMVQEVNKDFITTVKGVTVCATAGNGEEGM KLIKEEQPDLVILDVYMPKKDGIKTLQEIRKQKLEVDVIVVSAAKDKETISLMLQNGA VDYILKPFKLERMRQALEKYKQYKQKIEANDTLSQEQLDAILNIPQQAVQDLPKGLNH FTMNEVTAFLKQQTASLSAEEVAKALGIARVTARRYLDYLEKTGIIKLDVQYGGVGRP VNRYVLKG*" /label="dctR CDS" gene 480932..481612 /gene="dctR" /locus_tag="BSU_04460" /old_locus_tag="BSU04460" /label="dctR gene" S_feature 481613..481687 /Source="Nicolas_S_feature" /locus_tag="new_500046_500120" /HighExp="Sw, Diami, Mt0, G150, BI, Lbstat, M40t45, Lbtran, Mal, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S150" promotor_-35 481654..481661 /Source="Nicolas_upshift_promotors" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 481676..481693 /Source="Nicolas_upshift_promotors" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 481689 /Source="Nicolas_upshifts" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="upshifts" CDS 481733..482998 /gene="dctP" /locus_tag="BSU_04470" /old_locus_tag="BSU04470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10627041, 10708364, 12949159, 15849754, 16850406, 20363944, 22389480" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 10708364, 12949159, 15849754, 16850406, 20363944, 22389480; Product type t: transporter" /codon_start=1 /transl_table=11 /product="C4-dicarboxylate transport protein" /protein_id="NP_388328.1" /db_xref="EnsemblGenomes-Gn:BSU04470" /db_xref="EnsemblGenomes-Tr:CAB12254" /db_xref="GOA:P96603" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR023954" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG12075" /db_xref="UniProtKB/Swiss-Prot:P96603" /translation="MKLFKNLTVQVITAVIIGVIVGLVWPDVGKEMKPLGDTFINAVK MVIAPIIFFTIVLGIAKMGDMKKVGKVGGKAFIYFEVVTTLALIIGLFVVNIMKPGAG LDYSKLEKGDVSQYTQNGGQGIDWIEFITHIVPSNMVDAFAKGDILQVLFFSILFGVG LAALGEKGKSVIDFFDKVSHVFFKIIGYIMRAAPIGAFGAMAYTIGHFGLDSIKPLAS LMMSVYITMFLFVFVALNIICKLYGFSLWNYLRFIKDELLIVLGTSSSESVLPRMMDK MERYGCSKSVVGLVIPTGYSFNLDGTSIYLSMATVFLAQVFGVDLSIGQQITIILVLM LTSKGAAGVTGSGFIVLASTLSALQVIPLEGLALLLGVDRFMSEGRAIVNLIGNGIAT IIVAKSENEFDEAKSIEAVEGMKKMKTAV*" /label="dctP CDS" gene 481733..482998 /gene="dctP" /locus_tag="BSU_04470" /old_locus_tag="BSU04470" /label="dctP gene" downshifts 482991 /Source="Nicolas_upshifts" /id="D211" /incds=0 /nref=175 /ntot=235 /MaxReadThrough="3.99042" /MaxDrop="7.04798" /score="45.0636559" /energy="-12.6" /TU="NA" /idTUdmin="U351" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(483045) /Source="Nicolas_upshifts" /id="D212" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.588190000000001" /MaxDrop="3.06255" /score="19.3433396" /energy="-12.6" /TU="NA" /idTUdmin="U350" /TUdmin="-4818" /isTUend="FALSE" /label="downshifts" misc_feature 483082..483099 /Source="Nicolas_upshift_promotors" /id="U352" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.423576423576424" /psig="0.483516483516484" /xcortree=1457 /SigmaFactorBS="gtttttttaattgtttaagaattattaaggtaaggacagaga cctcagcatttttttgTTATATAATTTACAAATGgatactatattgaatgaaggacgt t" /listShort="ydbI, S151, ydbJ, ydbK, ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 483084 /Source="Nicolas_upshifts" /id="U352" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.423576423576424" /psig="0.483516483516484" /xcortree=1457 /SigmaFactorBS="gtttttttaattgtttaagaattattaaggtaaggacagaga cctcagcatttttttgTTATATAATTTACAAATGgatactatattgaatgaaggacgt t" /listShort="ydbI, S151, ydbJ, ydbK, ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="upshifts" CDS 483146..484198 /gene="ydbI" /locus_tag="BSU_04480" /old_locus_tag="BSU04480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388329.1" /db_xref="EnsemblGenomes-Gn:BSU04480" /db_xref="EnsemblGenomes-Tr:CAB12255" /db_xref="GOA:P96604" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG12076" /db_xref="UniProtKB/Swiss-Prot:P96604" /translation="MAALVKFFQHPGVRRFSIFVVLTGVLYLFKSMINLILLTFIFTF LMDRLELVVRQFVSQFFRVSQRVVITFLYMLLAVLLTVGGFVFYPVVAAQIQQLVKQI KHIAYHPDSIPFFDEITSVFGDINISSYVKEGFNVVYTYLADISTFGLQVVMALILSM FFLFEKKRLSEFMAKFKTSKLRVFYEEIAFFGSKFARTFGKVLEAQFIIALVNCILTF IALWIMHFPQLFGLSIMVFFLGLIPVAGVVISLIPLSIIAYSTGGGMYVLYIVLVIFA IHAIETYFLNPKLMSAKTELPIFFTFTVLIFSEHFFGIWGLIIGIPIFVFLLDILDVT NKEDRSKGPRENSDKK*" /label="ydbI CDS" gene 483146..484198 /gene="ydbI" /locus_tag="BSU_04480" /old_locus_tag="BSU04480" /label="ydbI gene" S_feature 484199..484442 /Source="Nicolas_S_feature" /locus_tag="new_502632_502875" /HighExp="S8, S5, S6, LoTm, S7, S3, LBGstat, LBGexp, Paraq, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.87223499999999998" /TUshortSig="Sig-" /TUshortPSig="0.484" /TUlongSig="NA" /TUlongPSig="NA" /label="S151" downshifts 484399 /Source="Nicolas_upshifts" /id="D213" /incds=0 /nref=6 /ntot=45 /MaxReadThrough="6.05001" /MaxDrop="3.52626" /score="17.6400305" /energy="-12.4" /TU="U352" /idTUdmin="U351" /TUdmin=1408 /isTUend="FALSE" /label="downshifts" CDS 484475..485401 /gene="ydbJ" /locus_tag="BSU_04490" /old_locus_tag="BSU04490" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding subunit)" /protein_id="NP_388330.1" /db_xref="EnsemblGenomes-Gn:BSU04490" /db_xref="EnsemblGenomes-Tr:CAB12256" /db_xref="GOA:P96605" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12077" /db_xref="UniProtKB/Swiss-Prot:P96605" /translation="MAEPILHIEGLDKKIGSKQILKQISMDVMEGEIIGLLGPNGSGK TTLIRIIVGLLKQNSGSVTISGFQHDTEFEKAMEAVGAIVENPEFYPYLTGWENLKHF ANMHKKIADERLDEVVERVGLTSAIHDKVKTYSLGMRQRLGIAQAILHRPKLLILDEP TNGLDPAGMKDFRDHIKELAEMEGTAVLFATHLLREVEDLCDRVIIIQKGEIKAEVSL QGTDQTTEKAIIEVQPQEKALNWLTGNQYQAESQDGTIVVEVAKENIPELNRSLVGQD LNVFSITPYTQSLEDEFIKATTAHQEEGEELV*" /label="ydbJ CDS" gene 484475..485401 /gene="ydbJ" /locus_tag="BSU_04490" /old_locus_tag="BSU04490" /label="ydbJ gene" CDS 485421..486161 /gene="ydbK" /locus_tag="BSU_04500" /old_locus_tag="BSU04500" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux ABC-transporter (permease subunit)" /protein_id="NP_388331.1" /db_xref="EnsemblGenomes-Gn:BSU04500" /db_xref="EnsemblGenomes-Tr:CAB12257" /db_xref="GOA:P96606" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG12078" /db_xref="UniProtKB/Swiss-Prot:P96606" /translation="MKLFNRKVTLVSLILMAVFQFFMALIIKRIVISAGTDENFIGYL SYTPSLNILLQALTIVIAATIVSMEFDKKTIKFLLIRPVKRQKVFWSKLITVVMVSFY LYLAYYILALLFGLLFFGTSVTAESKTLLVNTLALIGSNWLEAVMMGLFGLLCSSLFR NSAVAVVVSFVVLYGASTLVQLMKLFENKWGSFLLFANTDFTQYRSGETALFSGMTPL FSIGILIIHAIFFIVVGWWCFCKRDVRV*" /label="ydbK CDS" gene 485421..486161 /gene="ydbK" /locus_tag="BSU_04500" /old_locus_tag="BSU04500" /label="ydbK gene" misc_feature 486220..486239 /Source="Nicolas_upshift_promotors" /id="U353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.99000999000999" /xcortree=1624 /SigmaFactorBS="caaggaatgacatttttgtgaaaaagctcacgtaaatcaata tcatttgatatttTGGTTTATACTAAAGGTACTgacggaggtgtctcgattgaggaac t" /listShort="ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 486225 /Source="Nicolas_upshifts" /id="U353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.99000999000999" /xcortree=1624 /SigmaFactorBS="caaggaatgacatttttgtgaaaaagctcacgtaaatcaata tcatttgatatttTGGTTTATACTAAAGGTACTgacggaggtgtctcgattgaggaac t" /listShort="ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="upshifts" CDS 486256..486591 /gene="ydbL" /locus_tag="BSU_04510" /old_locus_tag="BSU04510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17928292; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative glyco-prenyl flippase subunit" /protein_id="NP_388332.1" /db_xref="EnsemblGenomes-Gn:BSU04510" /db_xref="EnsemblGenomes-Tr:CAB12258" /db_xref="GOA:P96607" /db_xref="SubtiList:BG12079" /db_xref="UniProtKB/Swiss-Prot:P96607" /translation="MRNFITALPIVLLLGFSFVSFMFQFEHLVYFRLALGLFSLVGLY MIYKMKTGIRYFIIYLYASWIVLAAVTAFEEPIFSSFFFGGLVMTMGYLTYMLIYLGM KQDRDANPV*" /label="ydbL CDS" gene 486256..486591 /gene="ydbL" /locus_tag="BSU_04510" /old_locus_tag="BSU04510" /label="ydbL gene" downshifts 486566 /Source="Nicolas_upshifts" /id="D214" /incds=0 /nref=2 /ntot=99 /MaxReadThrough="5.33473" /MaxDrop="5.39081" /score="25.8152101" /energy="-18.4" /TU="U352,U353" /idTUdmin="U352" /TUdmin="-1177" /isTUend="FALSE" /label="downshifts" S_feature 486611..486680 /Source="Nicolas_S_feature" /locus_tag="new_505044_505113" /HighExp="ferm, nit, S2, S0, Gly, M0t45, M0t90, Lbstat, M/G, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.99, 0.484" /TUlongSig="NA" /TUlongPSig="NA" /label="S152" promotor_-35 486646..486653 /Source="Nicolas_upshift_promotors" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 486667..486686 /Source="Nicolas_upshift_promotors" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 486681 /Source="Nicolas_upshifts" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="upshifts" CDS 486719..487864 /gene="ydbM" /locus_tag="BSU_04520" /old_locus_tag="BSU04520" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA dehydrogenase" /protein_id="NP_388333.1" /db_xref="EnsemblGenomes-Gn:BSU04520" /db_xref="EnsemblGenomes-Tr:CAB12259" /db_xref="GOA:P96608" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013107" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG12080" /db_xref="UniProtKB/Swiss-Prot:P96608" /translation="MSLFIQNDQQRQWMEKIGRIADEFQQTAAEDDEQGRFPAEKIQK LRDAGYTALTLPASHGGGGISVYDMLLFQERLARGDAPTALSIGWHLSVIGELGEGNS WDEDVFAFVAKEVQNGAVINRAATEAKTGSPTRGGRPGTHAVKKDGKWAVNGRKTFTT MSQALDYFLVTAWIEDKQTTGVFLIHKDDPGLSIEETWDMMAMRATGSHDLVLNEVML DENKLVELLQGPRGAKPNGWLLHIPAIYLGVAQAARDYAVQFASEYSPNSLNGPIKNV PAVQQRTGEMELELLNARHFLFHIAQLYDDPVRRPHLTSELGAAKHIVTNAALSVVDK AMRIVGAKSLERTNPLQRYYRDVRAGLHNPPMDDAVIHKLAAEAFES*" /label="ydbM CDS" gene 486719..487864 /gene="ydbM" /locus_tag="BSU_04520" /old_locus_tag="BSU04520" /label="ydbM gene" downshifts 487846 /Source="Nicolas_upshifts" /id="D215" /incds=0 /nref=13 /ntot=123 /MaxReadThrough="2.90782" /MaxDrop="4.20573" /score="9.48525091" /energy="-7" /TU="NA" /idTUdmin="U353" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(487889..488068) /gene="fbpB" /locus_tag="BSU_04530" /old_locus_tag="BSU04530" /experiment="publication(s) with functional evidences, PMID:12354229, 16428414, 18697947, 22427629" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16428414, 18697947, 22427629; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="NP_388334.1" /db_xref="EnsemblGenomes-Gn:BSU04530" /db_xref="EnsemblGenomes-Tr:CAB12260" /db_xref="GOA:P96609" /db_xref="InterPro:IPR025004" /db_xref="SubtiList:BG12081" /db_xref="UniProtKB/Swiss-Prot:P96609" /translation="MNTNMSGGRRSMPKRKVKTYQQLIQENKEAIMGNPKLMNVIYDR IDRKHQKNLQEQNNT*" /label="fbpB CDS" gene complement(487889..488068) /gene="fbpB" /locus_tag="BSU_04530" /old_locus_tag="BSU04530" /label="fbpB gene" downshifts complement(487907) /Source="Nicolas_upshifts" /id="D216" /incds=0 /nref=158 /ntot=207 /MaxReadThrough="2.35872" /MaxDrop="6.38199" /score="26.3317207" /energy="-7" /TU="NA" /idTUdmin="U355" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(488022..488186) /gene="fbpA" /locus_tag="BSU_04536" /old_locus_tag="BSU04536" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18697947" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="YP_009513944.1" /db_xref="EnsemblGenomes-Gn:BSU04536" /db_xref="EnsemblGenomes-Tr:CCQ48594" /db_xref="InterPro:IPR025072" /db_xref="UniProtKB/TrEMBL:L8ECQ9" /translation="MTPQSAEIRKKQLIHLLIQNGIYKKSKRHLYELSLTELESEYKH VRRAPEHAEA*" /label="fbpA CDS" gene complement(488022..488186) /gene="fbpA" /locus_tag="BSU_04536" /old_locus_tag="BSU04536" /label="fbpA gene" S_feature complement(488069..488237) /Source="Nicolas_S_feature" /locus_tag="new_506502_506670_c" /HighExp="B60, nit, B36, Lbexp, GM 15, GM 10, dia0, S2, GM 25, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99141199999999996" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S153" promotor_-10 complement(488229..488248) /Source="Nicolas_upshift_promotors" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(488239) /Source="Nicolas_upshifts" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(488263..488270) /Source="Nicolas_upshift_promotors" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 488378..488383 /Source="Nicolas_upshift_promotors" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 488399..488417 /Source="Nicolas_upshift_promotors" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 488403 /Source="Nicolas_upshifts" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="upshifts" CDS 488433..489305 /gene="ydbO" /locus_tag="BSU_04540" /old_locus_tag="BSU04540" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cation efflux system" /protein_id="NP_388335.1" /db_xref="EnsemblGenomes-Gn:BSU04540" /db_xref="EnsemblGenomes-Tr:CAB12261" /db_xref="GOA:P96610" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG12082" /db_xref="UniProtKB/Swiss-Prot:P96610" /translation="MERTENLKKGEKGALLNIFAYVILAVVKLVIGILYHSEALRADG LNNGTDIVASVAVLIGLRISQRPADSDHPYGHYRAETISSLVASFIMMAVGIEVLIGG GKAIAGGTTETPNLIAAWTALGSAVFMYGIYLYNKRLAASIKSSALMAAAKDSRSDAF VSAGAFIGVFSSQLKLPWVDPVTAFIIGIIICKTAWDIFKDASHSLTDGFHLKDLEPY KQTVGRIENVHRLKDVKARYLGSTVHIEMVITVDPKLTVEEGHGVADEVEDKIKHEHD VTHVHVHVEPDDIK*" /label="ydbO CDS" gene 488433..489305 /gene="ydbO" /locus_tag="BSU_04540" /old_locus_tag="BSU04540" /label="ydbO gene" promotor_-35 488669..488678 /Source="Nicolas_upshift_promotors" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 488691..488706 /Source="Nicolas_upshift_promotors" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 488694 /Source="Nicolas_upshifts" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(489250..489319) /Source="Nicolas_S_feature" /locus_tag="new_507683_507752_c" /HighExp="LPhT, dia15, dia5, Diami, Etha, Lbtran, LBGtran, LBGstat, Mt0, M0t45" /AntisenseName="ydbO" /AntisenseCor="0.18463882527998399" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S154" downshifts complement(489293) /Source="Nicolas_upshifts" /id="D217" /incds=0 /nref=145 /ntot=242 /MaxReadThrough="3.07579" /MaxDrop="6.00116" /score="9.69023537" /energy="-12.3" /TU="U359" /idTUdmin="U359" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" S_feature 489306..489655 /Source="Nicolas_S_feature" /locus_tag="new_507739_508088" /HighExp="Salt, Paraq, G135, ferm, Oxctl, T-0.40H, G150, Lbexp, T3.0H, T2.30H" /AntisenseName="ydbP" /AntisenseCor="-0.27800721625230801" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S155" CDS complement(489320..489640) /gene="ydbP" /locus_tag="BSU_04550" /old_locus_tag="BSU04550" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thioredoxin or thiol-disulfide isomerase" /protein_id="NP_388336.1" /db_xref="EnsemblGenomes-Gn:BSU04550" /db_xref="EnsemblGenomes-Tr:CAB12262" /db_xref="GOA:P96611" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12083" /db_xref="UniProtKB/Swiss-Prot:P96611" /translation="MKKITTNEQFNELIQSDKEIIVKFYADWCPDCTRMNMFIGDILE EYNQNDWYELNKDELPDLAEKYQVMGIPSLLIFKNGEKTAHLHSANAKTPEEVTEFLS EHIS*" /label="ydbP CDS" gene complement(489320..489640) /gene="ydbP" /locus_tag="BSU_04550" /old_locus_tag="BSU04550" /label="ydbP gene" promotor_-35 489636..489640 /Source="Nicolas_upshift_promotors" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 489649..489663 /Source="Nicolas_upshift_promotors" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 489657..489814 /Source="Nicolas_S_feature" /locus_tag="new_508090_508247" /HighExp="Lbexp, dia0, LBGexp, H2O2, Paraq, Oxctl, G180, Salt, M0t45, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigWXY" /TUshortPSig="0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S156" upshifts 489657 /Source="Nicolas_upshifts" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(489661..489680) /Source="Nicolas_upshift_promotors" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(489676) /Source="Nicolas_upshifts" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(489694..489701) /Source="Nicolas_upshift_promotors" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="promotor_-35" CDS 489815..490879 /gene="ddlA" /locus_tag="BSU_04560" /old_locus_tag="BSU04560" /EC_number="6.3.2.4" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8662022, 12682299, 22407814; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine ligase A" /protein_id="NP_388337.1" /db_xref="EnsemblGenomes-Gn:BSU04560" /db_xref="EnsemblGenomes-Tr:CAB12263" /db_xref="GOA:P96612" /db_xref="InterPro:IPR000291" /db_xref="InterPro:IPR005905" /db_xref="InterPro:IPR011095" /db_xref="InterPro:IPR011127" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG11932" /db_xref="UniProtKB/Swiss-Prot:P96612" /translation="MYGGKSAEHNVSLQTALAVIKALNTEKFDIHPIYITEKGEWVRG ARLTEPVSNVKMLQFEQGGSAFSPAALNQEMFPQEASQQNEAIDVVFPLLHGPNGEDG TIQGMLELLNIPYVGNGVLASSAGMDKVVMKHLFAQVGLAQAKYAAFLKKDWTRSPKE SCEEVEQELGYPCFVKPANLGSSVGISKCRNREELQKAFELAFQYDRKVVVEEGINGR EIEIGVLGNDDPKCSVVGEIAPKTDFYDYKAKYEDGDTDLMIPAIVTDEEYATISDMA IKAFKAIDGSGLVRADFFLTADGEVLINEVNTMPGFTPFSMFPLLWKEAGVEYADLIE QLVELAKERHAEKQLIKHTF*" /label="ddlA CDS" gene 489815..490879 /gene="ddlA" /locus_tag="BSU_04560" /old_locus_tag="BSU04560" /label="ddlA gene" downshifts 490867 /Source="Nicolas_upshifts" /id="D218" /incds=0 /nref=1 /ntot=59 /MaxReadThrough="5.68418" /MaxDrop="2.53103" /score="3.92144467" /energy="-9.6" /TU="U357,U358" /idTUdmin="U356" /TUdmin=2310 /isTUend="FALSE" /label="downshifts" CDS 490951..492324 /gene="murF" /locus_tag="BSU_04570" /old_locus_tag="BSU04570" /EC_number="6.3.2.10" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 17714441; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate-D-alanyl-D-alanine ligase" /protein_id="NP_388338.1" /db_xref="EnsemblGenomes-Gn:BSU04570" /db_xref="EnsemblGenomes-Tr:CAB12264" /db_xref="GOA:P96613" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005863" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR035911" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG12084" /db_xref="UniProtKB/Swiss-Prot:P96613" /translation="MIKRTVKNIAEMVKGTLANPQYEQTVIHGVATDTRKLEQHQLFI PLKGERFDGHSFVEQAFEAGVAAVLWDRSVPNPPENHAVILVDDTLTALQQLAKAYLQ ELGTRVIGVTGSNGKTTTKDMIHAVLGTQYRVHKTGGNFNNHIGLPLTVLAMPENTEI AVLEMGMSAKGEIDLLSRLANPDAAVITNIGESHMQDLGSREGIAEAKLEIINGLKED GVLIYIGDEPLLQNAYSCQTKTYGTGTHNDYQLQDVSQSEEGTHFTIKGIENTFFIPI LGKHNVMNAMAAIAAGAYFGIAPEDAAKGLSGLKVTGMRLELIKTDSGLSIINDAYNA SPTSMKAAIQLTESLEGYGKKMLVLGDMLELGDLEETFHKECGAVISPDKIDRVFTYG KLGAFIAEGALKHFEKDRVSHYTEKKDLLQAVKENASKGDLILFKASRGMKLEEIVKD LIESPLS*" /label="murF CDS" gene 490951..492324 /gene="murF" /locus_tag="BSU_04570" /old_locus_tag="BSU04570" /label="murF gene" promotor_-35 492355..492361 /Source="Nicolas_upshift_promotors" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 492375..492386 /Source="Nicolas_upshift_promotors" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 492385 /Source="Nicolas_upshifts" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" misc_feature 492428..492447 /Source="Nicolas_upshift_promotors" /id="U361" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2138 /SigmaFactorBS="tgatatgcaaacactaatgtatgccggccgaaaattatgtat atctggccggctgcggcTATGATACAATATATATAGGttatttcgcgatacgaacata t" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 492429..492603 /Source="Nicolas_S_feature" /locus_tag="new_510862_511036" /HighExp="Cold, ferm, nit, G135, S5, LBGexp, G150, S8, S7, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.76694499999999999" /TUshortSig="SigA, SigGF, Sig-, SigWXY" /TUshortPSig="1, 1, 0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S157" upshifts 492429 /Source="Nicolas_upshifts" /id="U361" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2138 /SigmaFactorBS="tgatatgcaaacactaatgtatgccggccgaaaattatgtat atctggccggctgcggcTATGATACAATATATATAGGttatttcgcgatacgaacata t" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 492571..492578 /Source="Nicolas_upshift_promotors" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 492593..492612 /Source="Nicolas_upshift_promotors" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 492605..492672 /Source="Nicolas_S_feature" /locus_tag="new_511038_511105" /HighExp="Cold, G150, T-3.40H, HPh, Salt, LPh, G180, G135, Oxctl, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigGF, Sig-, SigWXY" /TUshortPSig="1, 1, 1, 0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S158" upshifts 492605 /Source="Nicolas_upshifts" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="upshifts" CDS 492724..494208 /gene="cshA" /locus_tag="BSU_04580" /old_locus_tag="BSU04580" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16352840, 27965645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352840, 27965645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase; cold shock" /protein_id="NP_388339.2" /db_xref="EnsemblGenomes-Gn:BSU04580" /db_xref="EnsemblGenomes-Tr:CAB12265" /db_xref="GOA:P96614" /db_xref="InterPro:IPR000629" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030880" /db_xref="SubtiList:BG12085" /db_xref="UniProtKB/Swiss-Prot:P96614" /translation="MTITFQDFNLSSDLMKAINRMGFEEATPIQAQTIPLGLSNKDVI GQAQTGTGKTAAFGIPLVEKINPESPNIQAIVIAPTRELAIQVSEELYKIGQDKRAKV LPIYGGQDIGRQIRALKKNPNIIVGTPGRLLDHINRRTIRLNNVNTVVMDEADEMLNM GFIDDIESILSNVPSEHQTLLFSATMPAPIKRIAERFMTEPEHVKVKAKEMTVSNIQQ FYLEVQERKKFDTLTRLLDIQSPELAIVFGRTKRRVDELAEALNLRGYAAEGIHGDLT QAKRMVALRKFKEGAIEVLVATDVAARGLDISGVTHVYNFDVPQDPESYVHRIGRTGR AGKTGMAMTFITPREKSMLRAIEQTTKRKMDRMKEPTLDEALEGQQQVTVERLRTTIS ENNLNFYMTAAAELLEDHDAVTVVAAAIKMATKEPDDTPVRLTDEAPMVSKRYKNQRS SKRRDGQGGGYRGGKGKSNNRSSYDKKRSNDRRSSGDRRQKKSY*" /label="cshA CDS" gene 492724..494208 /gene="cshA" /locus_tag="BSU_04580" /old_locus_tag="BSU04580" /label="cshA gene" downshifts 494201 /Source="Nicolas_upshifts" /id="D219" /incds=0 /nref=309 /ntot=313 /MaxReadThrough="1.91428" /MaxDrop="8.13079" /score="26.104757" /energy="-13.1" /TU="NA" /idTUdmin="U358" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" S_feature 494321..494380 /Source="Nicolas_S_feature" /locus_tag="new_512754_512813" /HighExp="Etha, LBGexp, G180, Cold, Lbtran, dia0, G150, BMM, UNK1, MG-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S159" promotor_-35 494321..494330 /Source="Nicolas_upshift_promotors" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 494323 /Source="Nicolas_upshifts" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 494342..494357 /Source="Nicolas_upshift_promotors" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 494381..494860 /gene="ydbS" /locus_tag="BSU_04590" /old_locus_tag="BSU04590" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16629676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="resistance to heterologous antibiotics" /protein_id="NP_388340.1" /db_xref="EnsemblGenomes-Gn:BSU04590" /db_xref="EnsemblGenomes-Tr:CAB12266" /db_xref="GOA:P96615" /db_xref="InterPro:IPR005182" /db_xref="SubtiList:BG12086" /db_xref="UniProtKB/Swiss-Prot:P96615" /translation="MREQPKNQISPDGLKVWRLQEIIISAVCLLIVIAVAVLSYYFHW PYWISGVLGAVWLLGSIVTVFIIPKVRHKVWRYEVHEHEIDIQSGIFVVTRVIVPMVR VQHVDTSQGPLLKKYNLATVKISTAATVHSIPALEMEEADRLRDSISRLARVTDDDV* " /label="ydbS CDS" gene 494381..494860 /gene="ydbS" /locus_tag="BSU_04590" /old_locus_tag="BSU04590" /label="ydbS gene" CDS 494850..496331 /gene="ydbT" /locus_tag="BSU_04600" /old_locus_tag="BSU04600" /experiment="publication(s) with functional evidences, PMID:16629676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="resistance to heterologous antibiotics" /protein_id="NP_388341.1" /db_xref="EnsemblGenomes-Gn:BSU04600" /db_xref="EnsemblGenomes-Tr:CAB12267" /db_xref="GOA:P96616" /db_xref="InterPro:IPR005182" /db_xref="InterPro:IPR014529" /db_xref="SubtiList:BG12087" /db_xref="UniProtKB/Swiss-Prot:P96616" /translation="MMSEPKRLHPVAVILNLCHTIIQTIKNIILPFFFVYIVNSNHTV RFYGAIALGVLFIWLVAASIIKWRRFTYRIEDDEFRIEEGLFVTKKRYISIDRIQTMN TSAGLVQQIFKLVKLQIETAGGGKEAEAVLSAISVEEAERIKEAVFKKKAQRRENELD EERLEAEEELDPSVEVQEHYRMNAKELLMAASTSGGIGVIISAVFALISQLDEVLPMD WLFDKFSFLQHASIGIYAVLIFIGLFIAWIFSIAGMMFRYANFQIIKKEQELVISRGI IEKHQVTIPLRKIQAIKIKENIIRQLFGFVTVSIVSAGGGDREKEEGALTILFPMIHK KKLPHMLRTFTPEYTLEENCRRLPRRALKRYLFRSVIFSLFLIIPLCIFFQPWGYLSV ILLPIELLFGYLAYKEAAWTINGDRLQLTSRFIGRTTAIVLKKRMQVCKFSQSYFQKK GRLYTISTSVKSSSHMEELTVRDVGEEDAAFILKWYSYEKADG*" /label="ydbT CDS" gene 494850..496331 /gene="ydbT" /locus_tag="BSU_04600" /old_locus_tag="BSU04600" /label="ydbT gene" downshifts 496301 /Source="Nicolas_upshifts" /id="D220" /incds=0 /nref=6 /ntot=162 /MaxReadThrough="4.90913" /MaxDrop="3.0931" /score="48.2239319" /energy="-17.1" /TU="U363" /idTUdmin="U364" /TUdmin="-638" /isTUend="FALSE" /label="downshifts" S_feature 496346..496673 /Source="Nicolas_S_feature" /locus_tag="new_514779_515106" /HighExp="Salt, T0.30H, G135, T1.0H, T1.30H, G150, G180, Oxctl, T-0.40H, aero" /AntisenseName="ydcA" /AntisenseCor="-0.25636523135066602" /AntisenseRegPval="-4.7" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S160" downshifts complement(496355) /Source="Nicolas_upshifts" /id="D221" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="0.258529999999999" /MaxDrop="3.15455" /score="-3.74867023" /energy="-8.8" /TU="NA" /idTUdmin="U365" /TUdmin=220 /isTUend="FALSE" /label="downshifts" CDS complement(496583..497182) /gene="ydcA" /locus_tag="BSU_04610" /old_locus_tag="BSU04610" /EC_number="3.4.21.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15616571, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative rhomboid protease" /protein_id="NP_388342.1" /db_xref="EnsemblGenomes-Gn:BSU04610" /db_xref="EnsemblGenomes-Tr:CAB12268" /db_xref="GOA:P96617" /db_xref="InterPro:IPR022764" /db_xref="InterPro:IPR035952" /db_xref="SubtiList:BG12088" /db_xref="UniProtKB/Swiss-Prot:P96617" /translation="MFIRTENFQTFIRLYPVVTFILALQAVLWLFFSLPAHSVVLWRD TVTGYNLGVANGEWWRLITPILLHAGFTHLLFNSMSIFLFAPALERMLGKARFLLVYA GSGIIGNIGTYVTEPLDYVHVGASGAIFGLFGVYLFMVLFRNELIGQEHSKMIITLLA FAVLMSFINSNINMMAHLFGLCGGFLLSFLCVQKKERRY*" /label="ydcA CDS" gene complement(496583..497182) /gene="ydcA" /locus_tag="BSU_04610" /old_locus_tag="BSU04610" /label="ydcA gene" promotor_-35 496643..496648 /Source="Nicolas_upshift_promotors" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 496661..496680 /Source="Nicolas_upshift_promotors" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 496675..497276 /Source="Nicolas_S_feature" /locus_tag="new_515108_515709" /HighExp="Salt, G135, G150, T0.30H, G180, T1.0H, T1.30H, H2O2, Paraq, Oxctl" /AntisenseName="ydcA" /AntisenseCor="-0.11975373672841701" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S161" upshifts 496675 /Source="Nicolas_upshifts" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(497206..497225) /Source="Nicolas_upshift_promotors" /id="U365" /multdbtbs="SigE" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig="0.907092907092907" /xcortree=1402 /SigmaFactorBS="tgtatgataacctcctttgcgtacgtactatttaaatggttt gtctcataaaCGTGTTACTATAGATATACCaaaatgaagaaaaggggctcggaatgtt t" /listShort="ydcA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(497217) /Source="Nicolas_upshifts" /id="U365" /multdbtbs="SigE" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig="0.907092907092907" /xcortree=1402 /SigmaFactorBS="tgtatgataacctcctttgcgtacgtactatttaaatggttt gtctcataaaCGTGTTACTATAGATATACCaaaatgaagaaaaggggctcggaatgtt t" /listShort="ydcA" /GFF_Attribute="listLong" /label="upshifts" CDS 497277..497642 /gene="acpS" /locus_tag="BSU_04620" /old_locus_tag="BSU04620" /EC_number="2.7.8.7" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11489886, 11525165, 11867633, 12682299, 12926246, 15955059, 16597923; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="holo-acyl carrier protein synthase (phosphopantetheinyl transferase)" /protein_id="NP_388343.1" /db_xref="EnsemblGenomes-Gn:BSU04620" /db_xref="EnsemblGenomes-Tr:CAB12269" /db_xref="GOA:P96618" /db_xref="InterPro:IPR002582" /db_xref="InterPro:IPR004568" /db_xref="InterPro:IPR008278" /db_xref="InterPro:IPR037143" /db_xref="PDB:1F7L" /db_xref="PDB:1F7T" /db_xref="PDB:1F80" /db_xref="SubtiList:BG12089" /db_xref="UniProtKB/Swiss-Prot:P96618" /translation="MIYGIGLDITELKRIASMAGRQKRFAERILTRSELDQYYELSEK RKNEFLAGRFAAKEAFSKAFGTGIGRQLSFQDIEIRKDQNGKPYIICTKLSQAAVHVS ITHTKEYAAAQVVIERLSS*" /label="acpS CDS" gene 497277..497642 /gene="acpS" /locus_tag="BSU_04620" /old_locus_tag="BSU04620" /label="acpS gene" promotor_-35 497645..497650 /Source="Nicolas_upshift_promotors" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="promotor_-35" S_feature 497666..497807 /Source="Nicolas_S_feature" /locus_tag="new_516099_516240" /HighExp="S3, S4, BT, LoTm, S5, T5.0H, M9-stat, S7, T4.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S162" promotor_-10 497666..497684 /Source="Nicolas_upshift_promotors" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="promotor_-10" upshifts 497666 /Source="Nicolas_upshifts" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="upshifts" CDS 497808..498824 /gene="ydcC" /locus_tag="BSU_04630" /old_locus_tag="BSU04630" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14523133; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388344.2" /db_xref="EnsemblGenomes-Gn:BSU04630" /db_xref="EnsemblGenomes-Tr:CAB12270" /db_xref="GOA:P96619" /db_xref="InterPro:IPR029046" /db_xref="SubtiList:BG12090" /db_xref="UniProtKB/Swiss-Prot:P96619" /translation="MKKVRKSFVLLLTGLLAVLILSACGQKTQQDIVAGLDEKAKEYT SYKAKAKMTIETGSEPQVYNVEIWHKKPSLYRVYLENPKKDQNQVILRNENGVFVLTP SLNKSFRFQSDWPNNSSQVYLFESLVKDVQNDSDAVFTAKEKKYVFETKTNYQHNKML PTQEITFNKKDMSPSSVKVMDTDRKVMVKVEFSSFEFNKQFDKESFDEKKNMTLSQMD VATSAKPSDTFAVKTPLELPLGVKLLEEKDISTEDGKRIIMTYGGEKSFTLIQEKAQI AKASSSVTLNGEPVNLGYTIGALSDASLSWTYDGVDYLLSSKDLSKEEMVTVAKSMQG QSSK*" /label="ydcC CDS" gene 497808..498824 /gene="ydcC" /locus_tag="BSU_04630" /old_locus_tag="BSU04630" /label="ydcC gene" downshifts 498809 /Source="Nicolas_upshifts" /id="D222" /incds=0 /nref=193 /ntot=256 /MaxReadThrough="3.39815" /MaxDrop="6.13946" /score="22.0391647" /energy="-9.5" /TU="U366" /idTUdmin="U363" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 498869..498876 /Source="Nicolas_upshift_promotors" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 498890..498909 /Source="Nicolas_upshift_promotors" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 498897 /Source="Nicolas_upshifts" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 498939..500108 /gene="alrA" /locus_tag="BSU_04640" /old_locus_tag="BSU04640" /EC_number="5.1.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2835089, 12682299, 15043879, 18399999, 25227915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine racemase" /protein_id="NP_388345.1" /db_xref="EnsemblGenomes-Gn:BSU04640" /db_xref="EnsemblGenomes-Tr:CAB12271" /db_xref="GOA:P10725" /db_xref="InterPro:IPR000821" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR011079" /db_xref="InterPro:IPR020622" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG10950" /db_xref="UniProtKB/Swiss-Prot:P10725" /translation="MSTKPFYRDTWAEIDLSAIKENVSNMKKHIGEHVHLMAVVKANA YGHGDAETAKAALDAGASCLAVAILDEAISLRKKGLKAPILVLGAVPPEYVAIAAEYD VTLTGYSVEWLQEAARHTKKGSLHFHLKVDTGMNRLGVKTEEEVQNVMAILDRNPRLK CKGVFTHFATADEKERGYFLMQFERFKELIAPLPLKNLMVHCANSAAGLRLKKGFFNA VRFGIGMYGLRPSADMSDEIPFQLRPAFTLHSTLSHVKLIRKGESVSYGAEYTAEKDT WIGTVPVGYADGWLRKLKGTDILVKGKRLKIAGRICMDQFMVELDQEYPPGTKVTLIG RQGDEYISMDEIAGRLETINYEVACTISSRVPRMFLENGSIMEVRNPLLQVNISN*" /label="alrA CDS" gene 498939..500108 /gene="alrA" /locus_tag="BSU_04640" /old_locus_tag="BSU04640" /label="alrA gene" promotor_-35 500037..500042 /Source="Nicolas_upshift_promotors" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 500057..500075 /Source="Nicolas_upshift_promotors" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 500063 /Source="Nicolas_upshifts" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 500138..500141 /Source="Nicolas_upshift_promotors" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 500157..500176 /Source="Nicolas_upshift_promotors" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 500158 /Source="Nicolas_upshifts" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 500224..500505 /gene="ndoAI" /locus_tag="BSU_04650" /old_locus_tag="BSU04650" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15882409, 21763692, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15882409, 21763692, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="antitoxin EndoAI" /protein_id="NP_388346.1" /db_xref="EnsemblGenomes-Gn:BSU04650" /db_xref="EnsemblGenomes-Tr:CAB12272" /db_xref="GOA:P96621" /db_xref="InterPro:IPR002145" /db_xref="InterPro:IPR010985" /db_xref="InterPro:IPR013321" /db_xref="PDB:4ME7" /db_xref="SubtiList:BG12091" /db_xref="UniProtKB/Swiss-Prot:P96621" /translation="MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAY VSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAECEAETTVERLVSGG*" /label="ndoAI CDS" gene 500224..500505 /gene="ndoAI" /locus_tag="BSU_04650" /old_locus_tag="BSU04650" /label="ndoAI gene" CDS 500510..500860 /gene="ndoA" /locus_tag="BSU_04660" /old_locus_tag="BSU04660" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15882409, 21763692, 21897862, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15882409, 21763692, 21897862, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endoribonuclease toxin" /protein_id="NP_388347.1" /db_xref="EnsemblGenomes-Gn:BSU04660" /db_xref="EnsemblGenomes-Tr:CAB12273" /db_xref="GOA:P96622" /db_xref="InterPro:IPR003477" /db_xref="InterPro:IPR011067" /db_xref="PDB:1NE8" /db_xref="PDB:4MDX" /db_xref="PDB:4ME7" /db_xref="SubtiList:BG12092" /db_xref="UniProtKB/Swiss-Prot:P96622" /translation="MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIV AAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQIRTIDKQRLTDKITHLDDEMMDK VDEALQISLALIDF*" /label="ndoA CDS" gene 500510..500860 /gene="ndoA" /locus_tag="BSU_04660" /old_locus_tag="BSU04660" /label="ndoA gene" S_feature complement(500650..501126) /Source="Nicolas_S_feature" /locus_tag="new_519083_519559_c" /HighExp="Etha, Gly, Sw, S8, C30, S6, LBGstat, T0.30H, S7, Salt" /AntisenseName="ndoA" /AntisenseCor="-0.36117231948253697" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB, SigK" /TUshortPSig="1, 1, 0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S163" downshifts complement(500693) /Source="Nicolas_upshifts" /id="D223" /incds=1 /nref=6 /ntot=171 /MaxReadThrough="3.51096" /MaxDrop="3.79912" /score="-8.86444162" /energy="-10.2" /TU="U372" /idTUdmin="U371" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" downshifts 500840 /Source="Nicolas_upshifts" /id="D224" /incds=0 /nref=143 /ntot=254 /MaxReadThrough="5.57908" /MaxDrop="5.74865" /score="29.7721113" /energy="-8.9" /TU="U367,U368,U369" /idTUdmin="U366" /TUdmin=799 /isTUend="FALSE" /label="downshifts" promotor_-35 500894..500901 /Source="Nicolas_upshift_promotors" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 500915..500934 /Source="Nicolas_upshift_promotors" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 500923 /Source="Nicolas_upshifts" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 500975..501799 /gene="rsbRA" /locus_tag="BSU_04670" /old_locus_tag="BSU04670" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 16963570, 17158665, 11157946, 20019076, 21362065, 22287516, 23320651, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 16963570, 17158665, 11157946, 20019076, 21362065, 22287516, 23320651, 28271471; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome); positive regulation of sigma(B) activity in response to salt and heat stress" /protein_id="NP_388348.1" /db_xref="EnsemblGenomes-Gn:BSU04670" /db_xref="EnsemblGenomes-Tr:CAB12274" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR014792" /db_xref="InterPro:IPR036513" /db_xref="PDB:2BNL" /db_xref="SubtiList:BG11090" /db_xref="UniProtKB/Swiss-Prot:P42409" /translation="MMSNQTVYQFIAENQNELLQLWTDTLKELSEQESYQLTDQVYEN ISKEYIDILLLSVKDENAAESQISELALRAVQIGLSMKFLATALAEFWKRLYTKMNDK RLPDQESTELIWQIDRFFSPINTEIFNQYSISWEKTVSLQKIALQELSAPLIPVFENI TVMPLVGTIDTERAKRIMENLLNGVVKHRSQVVLIDITGVPVVDTMVAHHIIQASEAV RLVGAKCLLAGIRPEIAQTIVNLGIDLSQVITKNTLQKGIQTALEMTDRKIVSLGE*" /label="rsbRA CDS" gene 500975..501799 /gene="rsbRA" /locus_tag="BSU_04670" /old_locus_tag="BSU04670" /label="rsbRA gene" promotor_-10 complement(501109..501127) /Source="Nicolas_upshift_promotors" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(501126) /Source="Nicolas_upshifts" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(501128..501727) /Source="Nicolas_S_feature" /locus_tag="new_519561_520160_c" /HighExp="Etha, Sw, Gly, S6, S8, S7, B60, Salt, BT, M9-stat" /AntisenseName="rsbRA" /AntisenseCor="-0.53924606340364201" /AntisenseRegPval="-21" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK" /TUshortPSig="1, 0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S164" promotor_-35 complement(501141..501148) /Source="Nicolas_upshift_promotors" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(501716..501734) /Source="Nicolas_upshift_promotors" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(501727) /Source="Nicolas_upshifts" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(501729..502317) /Source="Nicolas_S_feature" /locus_tag="new_520162_520750_c" /HighExp="S6, S8, S7, BT, C30, S5, G135, C90, Gly, Fru" /AntisenseName="rsbS" /AntisenseCor="-0.57706416777859804" /AntisenseRegPval="-24.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S165" promotor_-35 complement(501748..501754) /Source="Nicolas_upshift_promotors" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="promotor_-35" CDS 501804..502169 /gene="rsbS" /locus_tag="BSU_04680" /old_locus_tag="BSU04680" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 11157946, 23320651, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 11157946, 23320651, 28271471; Product type f : factor" /codon_start=1 /transl_table=11 /product="antagonist of RsbT" /protein_id="NP_388349.1" /db_xref="EnsemblGenomes-Gn:BSU04680" /db_xref="EnsemblGenomes-Tr:CAB12275" /db_xref="GOA:P42410" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11091" /db_xref="UniProtKB/Swiss-Prot:P42410" /translation="MRHPKIPILKLYNCLLVSIQWELDDQTALTFQEDLLNKIYETGA NGVVIDLTSVDMIDSFIAKVLGDVITMSKLMGAKVVLTGIQPAVAVTLIELGIALEEI ETALDLEQGLETLKRELGE*" /label="rsbS CDS" gene 501804..502169 /gene="rsbS" /locus_tag="BSU_04680" /old_locus_tag="BSU04680" /label="rsbS gene" CDS 502173..502574 /gene="rsbT" /locus_tag="BSU_04690" /old_locus_tag="BSU04690" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 11157946, 20019076, 20558511, 21362065, 21979936, 23320651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 11157946, 20019076, 20558511, 21362065, 21979936, 23320651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="switch protein/serine-threonine kinase; controlsthe activity of the anxiosome (stressosome)" /protein_id="NP_388350.1" /db_xref="EnsemblGenomes-Gn:BSU04690" /db_xref="EnsemblGenomes-Tr:CAB12276" /db_xref="GOA:P42411" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11092" /db_xref="UniProtKB/Swiss-Prot:P42411" /translation="MNDQSCVRIMTEWDIVAARQLGRNVAKELGFGTVDQARITTAIS ELARNIYLYAGKGQIGIEQVADRGKKGLKIIAEDQGPGIPDIRKVMEDGFSTSGGLGA GLPGVKRLMDEFSLNSVAGEGTEIQAIKWLR*" /label="rsbT CDS" gene 502173..502574 /gene="rsbT" /locus_tag="BSU_04690" /old_locus_tag="BSU04690" /label="rsbT gene" promotor_-10 complement(502315..502334) /Source="Nicolas_upshift_promotors" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(502332) /Source="Nicolas_upshifts" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(502348..502357) /Source="Nicolas_upshift_promotors" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="promotor_-35" CDS 502586..503593 /gene="rsbU" /locus_tag="BSU_04700" /old_locus_tag="BSU04700" /EC_number="3.1.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 17303566, 21979936, 28461450" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 17303566, 21979936, 28461450; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein serine phosphatase; controls the activity of the anxiosome (stressosome)" /protein_id="NP_388351.1" /db_xref="EnsemblGenomes-Gn:BSU04700" /db_xref="EnsemblGenomes-Tr:CAB12277" /db_xref="GOA:P40399" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR014787" /db_xref="InterPro:IPR017944" /db_xref="InterPro:IPR036457" /db_xref="PDB:1W53" /db_xref="PDB:2J6Y" /db_xref="PDB:2J6Z" /db_xref="PDB:2J70" /db_xref="SubtiList:BG11057" /db_xref="UniProtKB/Swiss-Prot:P40399" /translation="MDFREVIEQRYHQLLSRYIAELTETSLYQAQKFSRKTIEHQIPP EEIISIHRKVLKELYPSLPEDVFHSLDFLIEVMIGYGMAYQEHQTLRGIQQEIKSEIE IAANVQQTLLGTKVPQEEALDIGAISVPAKQMSGDYYHFVKDKESINIAIADVIGKGI PAALCMSMIKYAMDSLPETGIHPSQVLKNLNRVVEQNVDASMFITMFYANYNMDKHQF TYASAGHEPGFYYSQKDNTFYDLEAKGLVLGISQDYDYKQFDQHLEKGDMIVLFSDGV TECRTENGFLERPDLQKLIEEHMCSSAQEMVKNIYDSLLKLQDFQLHDDFTLIVLRRK V*" /label="rsbU CDS" gene 502586..503593 /gene="rsbU" /locus_tag="BSU_04700" /old_locus_tag="BSU04700" /label="rsbU gene" promotor_-35 503587..503593 /Source="Nicolas_upshift_promotors" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 503608..503626 /Source="Nicolas_upshift_promotors" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 503614 /Source="Nicolas_upshifts" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 503655..503984 /gene="rsbV" /locus_tag="BSU_04710" /old_locus_tag="BSU04710" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15342585, 15583165, 16077134, 16885458, 20454630, 21979936, 27977677" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15342585, 15583165, 16077134, 16885458, 20454630, 21979936, 27977677; Product type f: factor" /codon_start=1 /transl_table=11 /product="anti-anti-sigma factor (antagonist of RsbW)" /protein_id="NP_388352.1" /db_xref="EnsemblGenomes-Gn:BSU04710" /db_xref="EnsemblGenomes-Tr:CAB12278" /db_xref="GOA:P17903" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR003658" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG10733" /db_xref="UniProtKB/Swiss-Prot:P17903" /translation="MNINVDVKQNENDIQVNIAGEIDVYSAPVLREKLVPLAEQGADL RICLKDVSYMDSTGLGVFVGTFKMVKKQGGSLKLENLSERLIRLFDITGLKDIIDISA KSEGGVQ*" /label="rsbV CDS" gene 503655..503984 /gene="rsbV" /locus_tag="BSU_04710" /old_locus_tag="BSU04710" /label="rsbV gene" CDS 503981..504463 /gene="rsbW" /locus_tag="BSU_04720" /old_locus_tag="BSU04720" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15342585, 15583165, 16077134, 16885458, 21979936, 27977677" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15342585, 15583165, 16077134, 16885458, 21979936, 27977677; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="switch protein/serine kinase and anti-sigma factor (inhibitory sigma-B binding protein)" /protein_id="NP_388353.1" /db_xref="EnsemblGenomes-Gn:BSU04720" /db_xref="EnsemblGenomes-Tr:CAB12279" /db_xref="GOA:P17904" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR010193" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10734" /db_xref="UniProtKB/Swiss-Prot:P17904" /translation="MKNNADYIEMKVPAQPEYVGIIRLTLSGVASRMGYTYDEIEDLK IAVSEACTNAVQHAYKEDKNGEVSIRFGVFEDRLEVIVADEGDSFDFDQKQQDLGPYT PSHTVDQLSEGGLGLYLMETLMDEVRVQNHSGVTVAMTKYLNGERVDHDTTIKNYETN *" /label="rsbW CDS" gene 503981..504463 /gene="rsbW" /locus_tag="BSU_04720" /old_locus_tag="BSU04720" /label="rsbW gene" CDS 504429..505217 /gene="sigB" /locus_tag="BSU_04730" /old_locus_tag="BSU04730" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15312768, 15805528, 16077134, 16267279, 16321960, 17158665, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15805528, 16077134, 16267279, 16321960, 17158665, 28271471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-37 factor (sigma(B))" /protein_id="NP_388354.2" /db_xref="EnsemblGenomes-Gn:BSU04730" /db_xref="EnsemblGenomes-Tr:CAB12280" /db_xref="GOA:P06574" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014288" /db_xref="InterPro:IPR014322" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10735" /db_xref="UniProtKB/Swiss-Prot:P06574" /translation="MTQPSKTTKLTKDEVDRLISDYQTKQDEQAQETLVRVYTNLVDM LAKKYSKGKSFHEDLRQVGMIGLLGAIKRYDPVVGKSFEAFAIPTIIGEIKRFLRDKT WSVHVPRRIKELGPRIKMAVDQLTTETQRSPKVEEIAEFLDVSEEEVLETMEMGKSYQ ALSVDHSIEADSDGSTVTILDIVGSQEDGYERVNQQLMLQSVLHVLSDREKQIIDLTY IQNKSQKETGDILGISQMHVSRLQRKAVKKLREALIEDPSMELM*" /label="sigB CDS" gene 504429..505217 /gene="sigB" /locus_tag="BSU_04730" /old_locus_tag="BSU04730" /label="sigB gene" CDS 505217..505816 /gene="rsbX" /locus_tag="BSU_04740" /old_locus_tag="BSU04740" /EC_number="3.1.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10671474, 12950928, 15466036, 9068644, 9658013, 21979936, 26057679" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10671474, 12950928, 15466036, 9068644, 9658013, 21979936, 26057679; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine phosphatase" /protein_id="NP_388355.1" /db_xref="EnsemblGenomes-Gn:BSU04740" /db_xref="EnsemblGenomes-Tr:CAB12281" /db_xref="GOA:P17906" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR036457" /db_xref="PDB:3W40" /db_xref="PDB:3W41" /db_xref="PDB:3W42" /db_xref="PDB:3W43" /db_xref="PDB:3W44" /db_xref="PDB:3W45" /db_xref="SubtiList:BG10736" /db_xref="UniProtKB/Swiss-Prot:P17906" /translation="MIQVEENEHIQTLVYQLNKEGKSICGDSFFMKADDKELICAVAD GLGSGSLANESSAAIKDLVENYASEDVESIIERCNQAMKNKRGATASILKINFEQRQF TYCSVGNVRFILHSPSGESFYPLPISGYLSGKPQKYKTHTATYEKGSKFIIHTDGLNV PDIRSHLKKGQSVEEISNSLKMYTTSRKDDLTYILGQLS*" /label="rsbX CDS" gene 505217..505816 /gene="rsbX" /locus_tag="BSU_04740" /old_locus_tag="BSU04740" /label="rsbX gene" downshifts 505802 /Source="Nicolas_upshifts" /id="D225" /incds=0 /nref=267 /ntot=278 /MaxReadThrough="2.46753" /MaxDrop="7.92167" /score="1.26147577" /energy="-6" /TU="NA" /idTUdmin="U369" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 505860..505866 /Source="Nicolas_upshift_promotors" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 505881..505900 /Source="Nicolas_upshift_promotors" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" Polymorphism join(505889,505891) /Source="geneious" /ID="SNP_BsDelta6_524323_524323" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="A -> C" /Codon_Change /Coverage=183 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=183 /comment="BSU_04745_promoter_down_mutation" /modified_by="User" / /label="Polymorphism_Delta6" upshifts 505893 /Source="Nicolas_upshifts" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 505927..506043 /locus_tag="BSU_04745" /old_locus_tag="BSU04745" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513945.1" /translation="MWNYEYTAIADVDVGKPGTVIRKQKQWINGRRVLHQIL*" /label="hypothetical protein CDS" gene 505927..506043 /locus_tag="BSU_04745" /old_locus_tag="BSU04745" /label="gene" CDS 506059..506352 /gene="ydcF" /locus_tag="BSU_04750" /old_locus_tag="BSU04750" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388356.1" /db_xref="EnsemblGenomes-Gn:BSU04750" /db_xref="EnsemblGenomes-Tr:CAB12282" /db_xref="SubtiList:BG12093" /db_xref="UniProtKB/Swiss-Prot:P96623" /translation="MERKEHCFCKEKQFSYGLSMWRNIGRFLSWSTCPHSNVIMEFFH VLQKQKEDLCITYGIVLEGAEAKKWGEIIGTELSKDMPTAVSRLVHLYGGVIK*" /label="ydcF CDS" gene 506059..506352 /gene="ydcF" /locus_tag="BSU_04750" /old_locus_tag="BSU04750" /label="ydcF gene" promotor_-35 506320..506328 /Source="Nicolas_upshift_promotors" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 506340..506359 /Source="Nicolas_upshift_promotors" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 506349..506789 /gene="ydcG" /locus_tag="BSU_04760" /old_locus_tag="BSU04760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388357.1" /db_xref="EnsemblGenomes-Gn:BSU04760" /db_xref="EnsemblGenomes-Tr:CAB12283" /db_xref="InterPro:IPR002740" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR022996" /db_xref="SubtiList:BG12094" /db_xref="UniProtKB/Swiss-Prot:P96624" /translation="MNTNYWIGVVSEQHVLKGAAGGFAQLCHGKKAPLAKMKEGDWLI YYSPRDAYPDGKLLRSFTAIGKVKSGNIYPYQMAPNFIPYRLDIDYYPCHKIGFYDIK SKLEFVQETKHLGFLFRRGHFEISKKDFLTIAQAMGVNISGMAL*" /label="ydcG CDS" gene 506349..506789 /gene="ydcG" /locus_tag="BSU_04760" /old_locus_tag="BSU04760" /label="ydcG gene" upshifts 506355 /Source="Nicolas_upshifts" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(506588..509643) /Source="Nicolas_S_feature" /locus_tag="new_525021_528076_c" /HighExp="S6, S8, S7, S5, B36, S4, B60, BT, Pyr, C30" /AntisenseName="ydcI" /AntisenseCor="-0.61304426345041496" /AntisenseRegPval="-28.4" /CDS_PredictionProba="0.40759499999999999" /TUshortSig="SigK" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S166" CDS 506773..507216 /gene="ydcH" /locus_tag="BSU_04770" /old_locus_tag="BSU04770" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12088660; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388358.1" /db_xref="EnsemblGenomes-Gn:BSU04770" /db_xref="EnsemblGenomes-Tr:CAB12284" /db_xref="GOA:P96625" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12095" /db_xref="UniProtKB/Swiss-Prot:P96625" /translation="MEWHSKFSGPNTSPGFLLWQATQSWQRKVGKALAEFDLTHVQFV LLTSCKYMIAHGETVTQKKLASFSQTNIMMVSEVVRTLEKKGFIERSKNPQDKREVLL SLTEIGGEKVTAALPIVEKIDQAFFAAAMKKENFLSGLQELLKHE*" /label="ydcH CDS" gene 506773..507216 /gene="ydcH" /locus_tag="BSU_04770" /old_locus_tag="BSU04770" /label="ydcH gene" downshifts 507191 /Source="Nicolas_upshifts" /id="D226" /incds=0 /nref=11 /ntot=147 /MaxReadThrough="2.17786" /MaxDrop="3.86856" /score="21.3746204" /energy="-6.8" /TU="NA" /idTUdmin="U376" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 507247..507248 /Source="Nicolas_upshift_promotors" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="promotor_-35" promotor_-10 507264..507283 /Source="Nicolas_upshift_promotors" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="promotor_-10" upshifts 507264 /Source="Nicolas_upshifts" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="upshifts" CDS 507310..509469 /gene="tex" /locus_tag="BSU_04780" /old_locus_tag="BSU04780" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8755871, 12910271, 15383836, 16282592; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA helicase transcriptional accessory protein" /protein_id="NP_388359.2" /db_xref="EnsemblGenomes-Gn:BSU04780" /db_xref="EnsemblGenomes-Tr:CAB12285" /db_xref="GOA:O31489" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR006641" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR018974" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR023319" /db_xref="InterPro:IPR023323" /db_xref="InterPro:IPR032639" /db_xref="SubtiList:BG12096" /db_xref="UniProtKB/Swiss-Prot:O31489" /translation="METSALLKQQIAKEIGLSQKHVESVIRLLEDGNTVPFIARYRKE QTGSMDEVQIQTISERWQYIQNLNQRKEEVIRLIAEQDKLTDNLKRKIEQSVKLQEVE DLYRPYKQKRKTKATVAKSKGLEPLADYILTLPQDDHLAATADQYISEEKEVFTREEA IEGAKHIIAEQISDEPTFRKWIRQETFKRGTIKSAAGKSADTDEKNVYEMYYEYEEPI AKVVPHRVLAMNRGEKEDILKVAIEPPADHIKAYLEKQIIKNRSTSVREILQETIEDS YKRLIQPAIEREIRKELSEKADEQAIHIFSENLRKLLLQPPMKGKTVLGVDPAFRTGC KLAVSDETGKVLKIDVIYPHAPVNKTKEAHEKVKKILEQYQVEMVAIGNGTASRETEQ FIVNVLRDMPRKIYYVIVNEAGASVYSASELAREEFPDLKVEERSAVSIARRLQDPLA ELVKIDPKSVGVGQYQHDVSQKRLNESLRFVVETVVNQVGVNVNTASAALLQYVAGLS KSVAGNVVKKREEIGKFSNRKELKDIPRLGAKTYEQCIGFLRVQEGTEPLDRTGIHPE SYKETKALLKKLGLSTEHIGTAELKDKINQLALSETAKELGIGEITLKDICEQLTRPE RDPRDKVPKPLLKTDVLQLEDLKEGMELQGTVRNVVDFGAFVDIGVKQDGLVHISKLS NQFVKHPLDVVSVGDIVTVWVDGVDVQKGRVSLSMVK*" /label="tex CDS" gene 507310..509469 /gene="tex" /locus_tag="BSU_04780" /old_locus_tag="BSU04780" /label="tex gene" misc_feature 509457..509476 /Source="Nicolas_upshift_promotors" /id="U378" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.999000999001" /xcortree=2162 /SigmaFactorBS="gacggcgtagatgtacaaaaaggcagagtatcgctgtcTATG GTAAAATAAAAGCACTgcttacgagcagtgttttttcctatagaaataccagcattga t" /listShort="S167, ydcK, S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1" /listLong="trnS-Leu2, S169" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 509479..509695 /Source="Nicolas_S_feature" /locus_tag="new_527912_528128" /HighExp="Cold, Etha, LBGstat, dia5, LPhT, T4.0H, dia15, T3.0H, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S167" upshifts 509479 /Source="Nicolas_upshifts" /id="U378" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.999000999001" /xcortree=2162 /SigmaFactorBS="gacggcgtagatgtacaaaaaggcagagtatcgctgtcTATG GTAAAATAAAAGCACTgcttacgagcagtgttttttcctatagaaataccagcattga t" /listShort="S167, ydcK, S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1" /listLong="trnS-Leu2, S169" /label="upshifts" CDS complement(509479..509592) /gene="cmpA" /locus_tag="BSU_04785" /old_locus_tag="BSU04785" /function="16.3: Control" /function="16.6: Maintain" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:22463703, 26387458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22463703, 26387458; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor allowing degradation of SpoIVA by ClpXP" /protein_id="YP_009513946.1" /translation="MPNWLKKQMQKAFLEKDNYQIKLLNQCWYFYRKKHCS*" /label="cmpA CDS" gene complement(509479..509592) /gene="cmpA" /locus_tag="BSU_04785" /old_locus_tag="BSU04785" /label="cmpA gene" promotor_-10 complement(509632..509651) /Source="Nicolas_upshift_promotors" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(509649) /Source="Nicolas_upshifts" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(509666..509674) /Source="Nicolas_upshift_promotors" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="promotor_-35" CDS 509696..510148 /gene="ydcK" /locus_tag="BSU_04790" /old_locus_tag="BSU04790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388360.1" /db_xref="EnsemblGenomes-Gn:BSU04790" /db_xref="EnsemblGenomes-Tr:CAB12286" /db_xref="GOA:P96628" /db_xref="InterPro:IPR006640" /db_xref="InterPro:IPR023524" /db_xref="InterPro:IPR035240" /db_xref="SubtiList:BG12098" /db_xref="UniProtKB/Swiss-Prot:P96628" /translation="MDNKELQKLTEDISETYFKKPFRHQALFNDRLKTTGGRYLLTSH NIELNRKYLIEHGREELIGIIKHELCHYHLHLEGKGYKHRDRDFRMLLQQVNAPRFCT PLKKKAENKKTYMYICTTCGQQYIKKRAMNPDRYRCGKCRGKIKRIFS*" /label="ydcK CDS" gene 509696..510148 /gene="ydcK" /locus_tag="BSU_04790" /old_locus_tag="BSU04790" /label="ydcK gene" promotor_-35 510154..510160 /Source="Nicolas_upshift_promotors" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 510175..510194 /Source="Nicolas_upshift_promotors" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 510183..510270 /Source="Nicolas_S_feature" /locus_tag="new_528616_528703" /HighExp="C30, LBGstat, Cold, UNK1, GM 25, GM 120, GM 15, Heat, T-3.40H, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S168" upshifts 510183 /Source="Nicolas_upshifts" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(510215) /Source="Nicolas_upshifts" /id="D227" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="2.50342" /MaxDrop="3.97305" /score="8.78044068" /energy="-9.2" /TU="NA" /idTUdmin="U381" /TUdmin=704 /isTUend="FALSE" /label="downshifts" tRNA 510271..510345 /gene="trnS-Asn" /locus_tag="BSU_tRNA_45" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asn(GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Asn tRNA" gene 510271..510345 /gene="trnS-Asn" /locus_tag="BSU_tRNA_45" /label="trnS-Asn gene" tRNA 510350..510440 /gene="trnS-Ser" /locus_tag="BSU_tRNA_46" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(GCU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Ser tRNA" gene 510350..510440 /gene="trnS-Ser" /locus_tag="BSU_tRNA_46" /label="trnS-Ser gene" tRNA 510470..510541 /gene="trnS-Glu" /locus_tag="BSU_tRNA_47" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Glu tRNA" gene 510470..510541 /gene="trnS-Glu" /locus_tag="BSU_tRNA_47" /label="trnS-Glu gene" tRNA 510553..510627 /gene="trnS-Gln" /locus_tag="BSU_tRNA_48" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Gln tRNA" gene 510553..510627 /gene="trnS-Gln" /locus_tag="BSU_tRNA_48" /label="trnS-Gln gene" tRNA 510654..510729 /gene="trnS-Lys" /locus_tag="BSU_tRNA_49" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Lys(UUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Lys tRNA" gene 510654..510729 /gene="trnS-Lys" /locus_tag="BSU_tRNA_49" /label="trnS-Lys gene" tRNA 510741..510822 /gene="trnS-Leu1" /locus_tag="BSU_tRNA_50" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Leu1 tRNA" gene 510741..510822 /gene="trnS-Leu1" /locus_tag="BSU_tRNA_50" /label="trnS-Leu1 gene" downshifts 510887 /Source="Nicolas_upshifts" /id="D228" /incds=0 /nref=3 /ntot=136 /MaxReadThrough="6.94232" /MaxDrop="3.5424" /score="34.987622" /energy="-13.7" /TU="U380" /idTUdmin="U378" /TUdmin=0 /isTUend="TRUE" /label="downshifts" tRNA 510903..>510988 /gene="trnS-Leu2" /locus_tag="BSU_tRNA_51" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu (GAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Leu2 tRNA" gene 510903..>510988 /gene="trnS-Leu2" /locus_tag="BSU_tRNA_51" /modified_by="User" /label="trnS-Leu2 gene" SCAR 510988..510989 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="Delta6_2" S_feature complement(<510989..511295) /Source="Nicolas_S_feature" /locus_tag="new_549923_550239_c" /HighExp="Diami, dia15, dia5, HPh, Etha, H2O2, Cold, LPh, C90, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /modified_by="User" /label="S175" downshifts 511008 /Source="Nicolas_upshifts" /id="D238" /incds=0 /nref=3 /ntot=115 /MaxReadThrough="0.144629999999999" /MaxDrop="3.58923" /score="4.45688042" /energy="-12.2" /TU="NA" /idTUdmin="U389" /TUdmin=84 /isTUend="FALSE" /label="downshifts" downshifts complement(511040) /Source="Nicolas_upshifts" /id="D239" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="2.31925" /MaxDrop="3.67068" /score="-2.66780619" /energy="-18.7" /TU="NA" /idTUdmin="U391" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(511296..512315) /gene="yddN" /locus_tag="BSU_05040" /old_locus_tag="BSU05040" /EC_number="1.14.14.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9836433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alkanal monooxygenase" /protein_id="NP_388385.1" /db_xref="EnsemblGenomes-Gn:BSU05040" /db_xref="EnsemblGenomes-Tr:CAB12311" /db_xref="GOA:P96651" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG12121" /db_xref="UniProtKB/Swiss-Prot:P96651" /translation="MKKFDISVLSVAPLRQGETMKQGIDSAVSLAKAVDNMGYKRIWF AEHHNHDAYASAATVSIVQHILANTKDIRVGSGGIMLPNHSPLIVAEQFGTLETLYPN RVDLALGRAPGTDQKTADVIRRSNHNGVFFFEREVNDILRFVGDKSVQGEVRAYPGIG THVPVFVLGSSTDSAEIAAKLGLPYAFGAQFSPHSMEEALSIYRENFQPSSYLQEPYV IACINVIAAESIDEASFISASHLQVYIDIYTNNLSKLIPPTENFLESLSQFELEILHS RLGYTIMGDRETIRRELIDFQQMYHADELIVLSNIYELSKEIQSYEILKQVVDELFKK RMEQL*" /label="yddN CDS" gene complement(511296..512315) /gene="yddN" /locus_tag="BSU_05040" /old_locus_tag="BSU05040" /label="yddN gene" promotor_-10 complement(511991..512010) /Source="Nicolas_upshift_promotors" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(512004) /Source="Nicolas_upshifts" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(512025..512032) /Source="Nicolas_upshift_promotors" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 512104..512108 /Source="Nicolas_upshift_promotors" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 512125..512144 /Source="Nicolas_upshift_promotors" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 512129 /Source="Nicolas_upshifts" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="upshifts" S_feature 512130..512574 /Source="Nicolas_S_feature" /locus_tag="new_551074_551518" /HighExp="dia15, dia5, H2O2, G180, G135, Paraq, HPh, LBGexp, Lbexp, G150" /AntisenseName="yddN" /AntisenseCor="0.70327972625798696" /AntisenseRegPval="-40.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S176" CDS 512575..512985 /gene="lrpA" /locus_tag="BSU_05050" /old_locus_tag="BSU05050" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11902725, 12675791, 17223133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902725, 12675791, 17223133; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388386.1" /db_xref="EnsemblGenomes-Gn:BSU05050" /db_xref="EnsemblGenomes-Tr:CAB12312" /db_xref="GOA:P96652" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12122" /db_xref="UniProtKB/Swiss-Prot:P96652" /translation="MIDEIDKKILDELSKNSRLTMKKLGEKVHLTAPATASRVVKLID NGIIKGCSIEVNQVKLGFSIHAFLNIYIEKIHHQPYLAFIETQDNYVINNYKVSGDGC YLLECKFPSNEVLDQFLNDLNKHANYKVSIVIGK*" /label="lrpA CDS" gene 512575..512985 /gene="lrpA" /locus_tag="BSU_05050" /old_locus_tag="BSU05050" /label="lrpA gene" S_feature 512986..513055 /Source="Nicolas_S_feature" /locus_tag="new_551930_551999" /HighExp="dia15, dia5, H2O2, HPh, G180, G135, LBGtran, Paraq, dia0, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S177" downshifts 513012 /Source="Nicolas_upshifts" /id="D240" /incds=0 /nref=45 /ntot=194 /MaxReadThrough="2.99689" /MaxDrop="3.6808" /score="-1.98969146" /energy="-15.7" /TU="U392" /idTUdmin="U392" /TUdmin="-350" /isTUend="FALSE" /label="downshifts" CDS complement(513108..513557) /gene="lrpB" /locus_tag="BSU_05060" /old_locus_tag="BSU05060" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11902725, 12675791, 17223133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902725, 12675791, 17223133; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388387.1" /db_xref="EnsemblGenomes-Gn:BSU05060" /db_xref="EnsemblGenomes-Tr:CAB12313" /db_xref="GOA:P96653" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12123" /db_xref="UniProtKB/Swiss-Prot:P96653" /translation="MQIDSIDFQILQLLNKNARIQWKEIGEKIHMTGQAVGNRIKKME DNGIIKAYSIVVDELKMGFSFTAFVFFFMNAYMHDDLLKFIATRNEISEAHRVSGDAC YLLKVTVHSQEVLNHLLNDLLKYGNYQLYLSIKEVKKHYNTSLMSDE*" /label="lrpB CDS" gene complement(513108..513557) /gene="lrpB" /locus_tag="BSU_05060" /old_locus_tag="BSU05060" /label="lrpB gene" CDS 513672..514214 /gene="yddQ" /locus_tag="BSU_05070" /old_locus_tag="BSU05070" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388388.1" /db_xref="EnsemblGenomes-Gn:BSU05070" /db_xref="EnsemblGenomes-Tr:CAB12314" /db_xref="GOA:P96654" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG12124" /db_xref="UniProtKB/Swiss-Prot:P96654" /translation="MTTALLVIDIQNDYFPNGKMALTNPEKAAQNAAKLLSHFRNTGA PVFHVQHITEGNIAHFFHPNTEGVEIHESVRPLEKETVIVKHMPNSFFNTDLNGKLQE EGVKELVVCGMMSHMCIDATVRSAVEHGYVCQVVEDACATTTLQIEDKIVPAEHVHYA FMAALNGVYATVKTTEAFLK*" /label="yddQ CDS" gene 513672..514214 /gene="yddQ" /locus_tag="BSU_05070" /old_locus_tag="BSU05070" /label="yddQ gene" promotor_-35 514687..514691 /Source="Nicolas_upshift_promotors" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 514708..514727 /Source="Nicolas_upshift_promotors" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 514717 /Source="Nicolas_upshifts" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="upshifts" CDS 514767..515531 /gene="yddR" /locus_tag="BSU_05080" /old_locus_tag="BSU05080" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388389.1" /db_xref="EnsemblGenomes-Gn:BSU05080" /db_xref="EnsemblGenomes-Tr:CAB12315" /db_xref="GOA:P96655" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG12125" /db_xref="UniProtKB/Swiss-Prot:P96655" /translation="MNITQIRNATIVVKYANKKFLIDPMLAEKGTYATFPETIRQDLF NPLVSLPTSIDNILDGVDAVIVTHLHLDHFDDVAKNVLPKNIKMFVQNEADAKEVKAS GFKNVEVLHQDTVFEGIQLVKTKGEHGRGEELLNLMGDVCGLVFKHPSEKVLYVAGDT VWYDAIEDEIHTHQPEIIVVNGGDNQRLDLGSLIMGKEDIYEVHKAAPHAKIISVHME AVNHWTLSREELKNFSKEKGFSSNILVPEDGESYTF*" /label="yddR CDS" gene 514767..515531 /gene="yddR" /locus_tag="BSU_05080" /old_locus_tag="BSU05080" /label="yddR gene" CDS 515725..517035 /gene="yddS" /locus_tag="BSU_05090" /old_locus_tag="BSU05090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388390.1" /db_xref="EnsemblGenomes-Gn:BSU05090" /db_xref="EnsemblGenomes-Tr:CAB12316" /db_xref="GOA:P96656" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12126" /db_xref="UniProtKB/Swiss-Prot:P96656" /translation="MVMTKKDTNISTQQPLWLQGYIDSPEKQNQLYKKTLKILIFSQI FGGAGLGAGITVGALLAQDMIGSENVAGIPTALFTFGSAVAALLIGASSQRFGRRAGL AGGFLIGGLGAIGVIIAALINSVALLFVSLLIYGAGMASNLQVRYAGTDLANEKQRAT AASMALVSTTLGAVVGPNLVNTMGEFADSIGVPNLAGPFIMSGAAFIIAGIILLIFLR PDPLFVSTAIANAEKKDDKVQIGGSLKNPAIDKKGIMVGAVIMILAQLIMTAIMTMTP VHMGHHGHGLSEVGLVIGLHIAAMYLPSPLTGLLVDKFGRTTMAIASGATLLAAGLVA AIAPADSLSLLILALVLLGVGWNFGLLTGTALIIDSTHPSLRAKTQGTFDVLLALSGA AGGALSGMVVAHSSYTILSISGAVLSLLLIPVVIWYFRRIQEKA*" /label="yddS CDS" gene 515725..517035 /gene="yddS" /locus_tag="BSU_05090" /old_locus_tag="BSU05090" /label="yddS gene" S_feature 517058..517617 /Source="Nicolas_S_feature" /locus_tag="new_556002_556561" /HighExp="S8, C30, Cold, BMM, C90, GM 25, MG 15, M/G, LPh, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S178" CDS 517618..517794 /gene="ydzM" /locus_tag="BSU_05099" /old_locus_tag="BSU05099" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved phage protein of unknown function" /protein_id="YP_003097682.1" /db_xref="EnsemblGenomes-Gn:BSU05099" /db_xref="EnsemblGenomes-Tr:CAX52553" /db_xref="GOA:Q9K3A9" /db_xref="UniProtKB/Swiss-Prot:Q9K3A9" /translation="MNNKKNIFDIVMYIIFGVLSLFLVAKTDYGTGVLVFVAILYLAV IAYKIKQVFSNSDS*" /label="ydzM CDS" gene 517618..517794 /gene="ydzM" /locus_tag="BSU_05099" /old_locus_tag="BSU05099" /label="ydzM gene" CDS 517819..518505 /gene="yddT" /locus_tag="BSU_05100" /old_locus_tag="BSU05100" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative exported phage protein" /protein_id="NP_388391.1" /db_xref="EnsemblGenomes-Gn:BSU05100" /db_xref="EnsemblGenomes-Tr:CAB12317" /db_xref="SubtiList:BG12127" /db_xref="UniProtKB/Swiss-Prot:P96657" /translation="MRKKRVITCVMAASLTLGSLLPAGYASAKEDSKTTPSYEELALH YKMKSEKISSNGKLVEIEYVSGNETHKVQMNGNNHTVKVDGIEQKGLNFEYDENVAKR TNYENNNLKSNEFTTQAAKPKKGYHYVGTLSGHTKAAKNALSVTMSLVGIVPGLGWGS KAATILFSYWAKEQIPDAYYKYDLYEKGAMTDSWYQYATVQFFEDKAHKKKMGKPWTS TPAKVDLPNS*" /label="yddT CDS" gene 517819..518505 /gene="yddT" /locus_tag="BSU_05100" /old_locus_tag="BSU05100" /label="yddT gene" promotor_-35 518847..518851 /Source="Nicolas_upshift_promotors" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="promotor_-35" promotor_-10 518866..518885 /Source="Nicolas_upshift_promotors" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="promotor_-10" upshifts 518874 /Source="Nicolas_upshifts" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="upshifts" Polymorphism join(518921,518923) /Source="geneious" /ID="SNP_BsDelta6_557866_557865" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(T)5 -> (T)6" /Codon_Change /Coverage=35 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="T" /Variant_P_Value="3.2e-123" /Variant_Raw_Frequency=35 /comment="ydzN_translation_signal_variant" /modified_by="User" / /label="Polymorphism_Delta6" CDS 518930..519115 /gene="ydzN" /locus_tag="BSU_05109" /old_locus_tag="BSU05109" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097683.1" /db_xref="EnsemblGenomes-Gn:BSU05109" /db_xref="EnsemblGenomes-Tr:CAX52554" /db_xref="GOA:C0H3V7" /db_xref="UniProtKB/Swiss-Prot:C0H3V7" /translation="MRWSKWFNVFCIVALGSIYGYKLFTNQEVSTTRLIIASVIVLWN IVGLFSKESVKQAQQAN*" /label="ydzN CDS" gene 518930..519115 /gene="ydzN" /locus_tag="BSU_05109" /old_locus_tag="BSU05109" /label="ydzN gene" downshifts 519114 /Source="Nicolas_upshifts" /id="D241" /incds=0 /nref=9 /ntot=125 /MaxReadThrough="3.39785" /MaxDrop="3.7067" /score="-6.31330934" /energy="-12.8" /TU="U394" /idTUdmin="U394" /TUdmin="-1068" /isTUend="FALSE" /label="downshifts" CDS 519465..520058 /gene="sufLC" /locus_tag="BSU_05110" /old_locus_tag="BSU05110" /experiment="publication(s) with functional evidences, PMID:24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyoxalase III homolog, deglycase" /protein_id="NP_388392.1" /db_xref="EnsemblGenomes-Gn:BSU05110" /db_xref="EnsemblGenomes-Tr:CAB12318" /db_xref="GOA:P96658" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR029062" /db_xref="PDB:3F5D" /db_xref="SubtiList:BG12128" /db_xref="UniProtKB/Swiss-Prot:P96658" /translation="MKKALFLILDQYADWEGVYLASALNQREDWSVHTVSLDPIVSSI GGFKTSVDYIIGLEPANFNLLVMIGGDSWSNDNKKLLHFVKTAFQKNIPIAAICGAVD FLAKNGLLNNHSHTGNFVYLWKDYKQYKPISSFVEKQAVRDKNLVTANGTAPIEFTNL ILEMIDFDTPENIEKMMYMNRYGFYHFCDKYGNPFVD*" /label="sufLC CDS" gene 519465..520058 /gene="sufLC" /locus_tag="BSU_05110" /old_locus_tag="BSU05110" /label="sufLC gene" promotor_-35 520171..520178 /Source="Nicolas_upshift_promotors" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 520192..520211 /Source="Nicolas_upshift_promotors" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 520203..520320 /Source="Nicolas_S_feature" /locus_tag="new_559146_559263" /HighExp="B60, LoTm, T5.0H, T3.30H, M9-stat, BI, BC, C90, T3.0H, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S179" upshifts 520203 /Source="Nicolas_upshifts" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(520238) /Source="Nicolas_upshifts" /id="D242" /incds=0 /nref=10 /ntot=93 /MaxReadThrough="1.86628" /MaxDrop="4.19111" /score="25.1917407" /energy="-12.9" /TU="NA" /idTUdmin="U396" /TUdmin=328 /isTUend="FALSE" /label="downshifts" CDS 520321..520521 /gene="cspC" /locus_tag="BSU_05120" /old_locus_tag="BSU05120" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9379903, 9914312, 9920884, 10517332, 11591689, 12427936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9379903, 9914312, 9920884, 10517332, 11591689, 12427936; Product type f : factor" /codon_start=1 /transl_table=11 /product="cold-shock protein" /protein_id="NP_388393.1" /db_xref="EnsemblGenomes-Gn:BSU05120" /db_xref="EnsemblGenomes-Tr:CAB12319" /db_xref="GOA:P39158" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="SubtiList:BG11024" /db_xref="UniProtKB/Swiss-Prot:P39158" /translation="MEQGTVKWFNAEKGFGFIERENGDDVFVHFSAIQSDGFKSLDEG QKVSFDVEQGARGAQAANVQKA*" /label="cspC CDS" gene 520321..520521 /gene="cspC" /locus_tag="BSU_05120" /old_locus_tag="BSU05120" /label="cspC gene" S_feature complement(520419..521207) /Source="Nicolas_S_feature" /locus_tag="new_559362_560150_c" /HighExp="LoTm, B60, Cold, M9-stat, LPhT, B36, Sw, BC, S8, Salt" /AntisenseName="cspC" /AntisenseCor="0.39074308987975698" /AntisenseRegPval="-10.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S180" downshifts 520424 /Source="Nicolas_upshifts" /id="D243" /incds=1 /nref=19 /ntot=179 /MaxReadThrough="8.05368" /MaxDrop="3.4464" /score="27.3387234" /energy="-11.3" /TU="U395" /idTUdmin="U394" /TUdmin=242 /isTUend="FALSE" /label="downshifts" downshifts 520525 /Source="Nicolas_upshifts" /id="D244" /incds=0 /nref=65 /ntot=246 /MaxReadThrough="5.78621" /MaxDrop="5.83905" /score="27.3387234" /energy="-11.3" /TU="U395" /idTUdmin="U394" /TUdmin=343 /isTUend="FALSE" /label="downshifts" misc_RNA complement(520589..520667) /gene="sncZ" /locus_tag="BSU_misc_RNA_66" /product="putative small conserved untranslated RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="sncZ RNA" gene complement(520589..520667) /gene="sncZ" /locus_tag="BSU_misc_RNA_66" /label="sncZ gene" CDS complement(521208..521669) /gene="cdnL" /locus_tag="BSU_05130" /old_locus_tag="BSU05130" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 26849219; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for repair and outgrowth of heat damaged spores" /protein_id="NP_388394.1" /db_xref="EnsemblGenomes-Gn:BSU05130" /db_xref="EnsemblGenomes-Tr:CAB12320" /db_xref="InterPro:IPR003711" /db_xref="InterPro:IPR036101" /db_xref="SubtiList:BG12129" /db_xref="UniProtKB/Swiss-Prot:P96659" /translation="MFQIGDNIVYPMHGAGIIEAIEEKEFLEEKQQYYVIRMSISNMT VMIPTSKILSSNIRPVTDILALKHIMHIFQHGESDRLLPWKQRYKINTDKIKTGEIQE GAEVVRDLMRMKKEKALNASEKKMLDNAYEFLISELEVIKGITEKQIKSFG*" /label="cdnL CDS" gene complement(521208..521669) /gene="cdnL" /locus_tag="BSU_05130" /old_locus_tag="BSU05130" /label="cdnL gene" S_feature 521678..522223 /Source="Nicolas_S_feature" /locus_tag="new_560621_561166" /HighExp="Cold, G135, S8, G180, LoTm, S7, G150, HPh, Paraq, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S181" upshifts complement(521721) /Source="Nicolas_upshifts" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(521728..521747) /Source="Nicolas_upshift_promotors" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(521763..521770) /Source="Nicolas_upshift_promotors" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 522190 /Source="Nicolas_upshifts" /id="D245" /incds=0 /nref=7 /ntot=141 /MaxReadThrough="0.289110000000001" /MaxDrop="4.3701" /score="26.1823933" /energy="-9.5" /TU="NA" /idTUdmin="U395" /TUdmin=864 /isTUend="FALSE" /label="downshifts" CDS complement(522237..522473) /gene="ydzE" /locus_tag="BSU_05140" /old_locus_tag="BSU05140" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388395.1" /db_xref="EnsemblGenomes-Gn:BSU05140" /db_xref="EnsemblGenomes-Tr:CAB12321" /db_xref="GOA:O31493" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12808" /db_xref="UniProtKB/Swiss-Prot:O31493" /translation="MYLGIVSTACAFLLWNHGLQLLNASSGGLFFFFQPLVGTLLGWI LLGEQIGGTFWIGSFLILSGVLLVIKEKEKEVKS*" /label="ydzE CDS" gene complement(522237..522473) /gene="ydzE" /locus_tag="BSU_05140" /old_locus_tag="BSU05140" /label="ydzE gene" CDS complement(522571..523446) /gene="ydeC" /locus_tag="BSU_05150" /old_locus_tag="BSU05150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388396.1" /db_xref="EnsemblGenomes-Gn:BSU05150" /db_xref="EnsemblGenomes-Tr:CAB12322" /db_xref="GOA:P96660" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="SubtiList:BG12130" /db_xref="UniProtKB/Swiss-Prot:P96660" /translation="MKNFVIDQNLKELTEHRTVELPVACYKTTINQNINGYIPLHWHD EIQFVLILKGIALFQINEEKIEVHEGDGLFINSGYLHMAEEKEGSDCTYICLNVSPHF VLSQELYSSYVQPYMFSTNLPYLFLAGNQQWAKNILDAVKKINQLIQQKTSLYEIDIT MQLTLMWKNLVVNGFQLEYDQSEMIKSHRMKQMLNWIHLHYVEKITLEDIAKAGQLSR SECCRYFKRMLNKTPLRYVMDYRIQKSLLLLQHPESNVTEVSYQVGFNSTSYFISKFQ QAMNMTPLSYKKMNS*" /label="ydeC CDS" gene complement(522571..523446) /gene="ydeC" /locus_tag="BSU_05150" /old_locus_tag="BSU05150" /label="ydeC gene" CDS 523559..524518 /gene="ydeD" /locus_tag="BSU_05160" /old_locus_tag="BSU05160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388397.1" /db_xref="EnsemblGenomes-Gn:BSU05160" /db_xref="EnsemblGenomes-Tr:CAB12323" /db_xref="GOA:P96661" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12131" /db_xref="UniProtKB/Swiss-Prot:P96661" /translation="MNTSNRRMGLFYVITGATCWGIGGTVAKKLFQEYQIDVNWLVTT RLLTAGMLLLMLQLFRKDRSQVIEVWKHKASAGQLLIFGLLGMLAVQYTYMASIQHGN AAVATLLQYLSPVIVIIYTLLRKQTVLTKQDIITVVLALVGCFFLLTNGSMSQLSVPA AAVVWGVLSGFAAAFYTLYAVGLLNKFDSLVVVGWAMIIGGFALGFIHPPWQLDFQRL TAEAYAYILFVILFGTMIAFWFFIKSLESLSPKETSLLGSLEPLSAVVTTVVWLKAPF GSFQWIGAICIIGITLILALHKEPSMESEKSILKIRNHANRDI*" /label="ydeD CDS" gene 523559..524518 /gene="ydeD" /locus_tag="BSU_05160" /old_locus_tag="BSU05160" /label="ydeD gene" upshifts complement(523580) /Source="Nicolas_upshifts" /id="U397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.808191808191808" /xcortree=1969 /SigmaFactorBS="tggctactgtgcctccaatcccccaacatgtcgccccTGTGA TAACATAGAACAATCccattcttctattggaagtattcatacatgactcctcactaat a" /listShort="ydeC" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(523584..523603) /Source="Nicolas_upshift_promotors" /id="U397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.808191808191808" /xcortree=1969 /SigmaFactorBS="tggctactgtgcctccaatcccccaacatgtcgccccTGTGA TAACATAGAACAATCccattcttctattggaagtattcatacatgactcctcactaat a" /listShort="ydeC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(524671..525543) /gene="ydeE" /locus_tag="BSU_05170" /old_locus_tag="BSU05170" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388398.1" /db_xref="EnsemblGenomes-Gn:BSU05170" /db_xref="EnsemblGenomes-Tr:CAB12324" /db_xref="GOA:P96662" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG12132" /db_xref="UniProtKB/Swiss-Prot:P96662" /translation="MDLLKSMNRALKYIEENLTNDIDFQEAAKLAFCSEYHFKRMFSF LAGISLSEYIRRRRLTLAAFELKDSNVKVIDIAIKYGYNSPDSFARAFQNLHGINPSK ARFNGHSLKAYPRMTFQLTIKGGNEMNYRIEEKEAFRIVGIKKRVPIIFKGINPEIAS MWESLDEKAINKLKELSNVAPSGLISASTNFSEGRTEENGELDHYIGAATTKRCPDNF SRLEVPASTWAVFESIGPFPDTLQEVWGRIYSEWFPSSNYEQIEGPEILWNEHKDVTS PSFKSEIWIPITKK*" /label="ydeE CDS" gene complement(524671..525543) /gene="ydeE" /locus_tag="BSU_05170" /old_locus_tag="BSU05170" /label="ydeE gene" promotor_-10 complement(525636..525641) /Source="Nicolas_upshift_promotors" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(525643..525644) /Source="Nicolas_upshift_promotors" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(525648) /Source="Nicolas_upshifts" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 525717..525723 /Source="Nicolas_upshift_promotors" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 525731 /Source="Nicolas_upshifts" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 525737..525756 /Source="Nicolas_upshift_promotors" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 525770..527158 /gene="ydeF" /locus_tag="BSU_05180" /old_locus_tag="BSU05180" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388399.2" /db_xref="EnsemblGenomes-Gn:BSU05180" /db_xref="EnsemblGenomes-Tr:CAB12325" /db_xref="GOA:P96663" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12133" /db_xref="UniProtKB/Swiss-Prot:P96663" /translation="MPINSFENYPMSWKPSIDKAEKPIYKALAGQLEQDILNGVLLPG TKLPPQRELADYLDLNVSTISKAFKVCELKGLLSATVGSGTFVSYDALSNAYLLEDTK PTHLIEMGAILPDHASYEPLLYQLKNMVHEEDYEKWFSYGRAGESLWQKDAAVKLIQR GGFETSVDHILFANGGQNAIAATLASLCKPGDRIGVDHHTYPGLKTVASLLSVQIVPI KSENDEMSPESLEYACKNENIKGLYLIPDYHNPTTSFMSVENRRMVADIVKKYNLFVI EDASYHLLNKNPLPALASFAPQQVIHIASLSKSLAPGLRLAYVAVPRQYKEPISKALY NLNITVSPLLAELTARTIVSNQFEVLIESHREQTIRRNQLVNRYVAGYTCLGVETGIF RWLLLPGKMSGAEFEELAARLGVQVYAAERFVVGNSCPERAVRVSVCAPKTLEELEQG LMILRRLLDDLT*" /label="ydeF CDS" gene 525770..527158 /gene="ydeF" /locus_tag="BSU_05180" /old_locus_tag="BSU05180" /label="ydeF gene" downshifts 527134 /Source="Nicolas_upshifts" /id="D246" /incds=0 /nref=2 /ntot=61 /MaxReadThrough="0.91547" /MaxDrop="3.65963" /score="12.298375" /energy="-12.2" /TU="NA" /idTUdmin="U399" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS 527268..528560 /gene="ydeG" /locus_tag="BSU_05190" /old_locus_tag="BSU05190" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388400.1" /db_xref="EnsemblGenomes-Gn:BSU05190" /db_xref="EnsemblGenomes-Tr:CAB12326" /db_xref="GOA:P96664" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12134" /db_xref="UniProtKB/Swiss-Prot:P96664" /translation="MMLDKDSVKAIDVQTASLQSYISSPEKQKSLYKRTLFVVSISQI FGGAGLAAGVTVGALIAQQMLGTDAFAGLPSALFTLGSAGSALIVGRLSQRYGRRTGL SAGFMIGGLGAIGVIMAAIINSIFLLFISLLIYGAGTATNLQARYAGTDLANHKQRAT AVSITMVFTTFGAVAGPSLVNVMGDFALSIGVPSLAGPFILAAAAYMLAGVVLFIMLR PDPLVIARTIEAANEEPGDKGHLAATEHTENKKGIIVGATVMVLTQIVMVAIMTMTPV HMRHHGHDLGAVGLVIGFHIGAMYLPSLVTGVLVDRLGRTAMAISSGTTLLLAGVIAA FAPGESMILLVIALSLLGLGWNFGLISGTALIVDSTDTATRAKTQGTVDVLIALSGAA GGALSGMIVAGSSYLALSLIGGILSLLLIPVVVWSRGR*" /label="ydeG CDS" gene 527268..528560 /gene="ydeG" /locus_tag="BSU_05190" /old_locus_tag="BSU05190" /label="ydeG gene" promotor_-35 528569..528575 /Source="Nicolas_upshift_promotors" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 528590..528609 /Source="Nicolas_upshift_promotors" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 528597 /Source="Nicolas_upshifts" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="upshifts" S_feature 528608..528718 /Source="Nicolas_S_feature" /locus_tag="new_567551_567661" /HighExp="LoTm, T4.0H, T3.30H, T2.30H, T3.0H, T2.0H, T1.30H, T5.0H, T1.0H, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S182" CDS 528719..529165 /gene="ydeH" /locus_tag="BSU_05200" /old_locus_tag="BSU05200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388401.1" /db_xref="EnsemblGenomes-Gn:BSU05200" /db_xref="EnsemblGenomes-Tr:CAB12327" /db_xref="GOA:P96665" /db_xref="SubtiList:BG12135" /db_xref="UniProtKB/Swiss-Prot:P96665" /translation="MNHIKWLSDLKKAGLLALGKGVITLLKRFSLVIVTLMMSIVVVL AAAKESPGDHVISFDEPIILMISIGIVVFLLIPPLVMSFFGNLVVRIISGVYQCFIVF TFLGLIPIGFLIPNGFLTILVSIAGTLVSIASVAVTLCIGKNKKDI*" /label="ydeH CDS" gene 528719..529165 /gene="ydeH" /locus_tag="BSU_05200" /old_locus_tag="BSU05200" /label="ydeH gene" downshifts 529194 /Source="Nicolas_upshifts" /id="D247" /incds=0 /nref=200 /ntot=251 /MaxReadThrough="2.56495" /MaxDrop="6.50538" /score="-1.7193297" /energy="-4.5" /TU="NA" /idTUdmin="U400" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 529245..529252 /Source="Nicolas_upshift_promotors" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 529267..529286 /Source="Nicolas_upshift_promotors" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 529268 /Source="Nicolas_upshifts" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="upshifts" CDS 529402..529995 /gene="ydeI" /locus_tag="BSU_05210" /old_locus_tag="BSU05210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16390439" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388402.1" /db_xref="EnsemblGenomes-Gn:BSU05210" /db_xref="EnsemblGenomes-Tr:CAB12328" /db_xref="InterPro:IPR014922" /db_xref="InterPro:IPR016786" /db_xref="SubtiList:BG12136" /db_xref="UniProtKB/Swiss-Prot:P96666" /translation="MTNSRTNPKVDEFLSKAKKWKEEFEKLRTIILDCELTEDFKWMH PCYTYHNKNIVLIHGFKEYCALLFHKGVLLQDTDGILIQQTENVQAARQIRFTNVQEI NELENILKAYIHEAIEVEKAGLKVDVNKNIELNIPEELQNKFDEIPALKIAFEALTPG RQRAYTLYFSQAKQSKTRESRVEKYVQKILDGKGLKD*" /label="ydeI CDS" gene 529402..529995 /gene="ydeI" /locus_tag="BSU_05210" /old_locus_tag="BSU05210" /label="ydeI gene" downshifts 530038 /Source="Nicolas_upshifts" /id="D248" /incds=0 /nref=2 /ntot=40 /MaxReadThrough="1.63432" /MaxDrop="2.96785" /score="2.93671425" /energy="-6.9" /TU="NA" /idTUdmin="U401" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(530114) /Source="Nicolas_upshifts" /id="D249" /incds=0 /nref=1 /ntot=64 /MaxReadThrough="2.19009" /MaxDrop="2.9369" /score="-1.28013562" /energy="-6.9" /TU="NA" /idTUdmin="U403" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 530127..530134 /Source="Nicolas_upshift_promotors" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 530148 /Source="Nicolas_upshifts" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 530149..530168 /Source="Nicolas_upshift_promotors" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(530347..531006) /gene="ydeJ" /locus_tag="BSU_05220" /old_locus_tag="BSU05220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388403.1" /db_xref="EnsemblGenomes-Gn:BSU05220" /db_xref="EnsemblGenomes-Tr:CAB12329" /db_xref="GOA:P96667" /db_xref="SubtiList:BG12137" /db_xref="UniProtKB/Swiss-Prot:P96667" /translation="MKKRRKICYCNTALLLMILLAGCTDSKDGEAQQPSNQASAVQTD EKHTEPEESTKIRKDEAEPITESEESATKAANDTSSAEEKSKEDNVLAAYSSEKIEYA RVWLQLGPNQEIDELNVRHIAAGEPINPNDDTSASYPENVTQLAGSRLVDGSVTYHGN GDGTIHVYNVPLRWDSADDIEKGVMREVTESIIKNRKTVYVDTGDDEKIKRLIDIMMI H*" /label="ydeJ CDS" gene complement(530347..531006) /gene="ydeJ" /locus_tag="BSU_05220" /old_locus_tag="BSU05220" /label="ydeJ gene" promotor_-10 complement(531055..531074) /Source="Nicolas_upshift_promotors" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(531062) /Source="Nicolas_upshifts" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(531086..531091) /Source="Nicolas_upshift_promotors" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(531428..532291) /gene="ydeK" /locus_tag="BSU_05230" /old_locus_tag="BSU05230" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388404.1" /db_xref="EnsemblGenomes-Gn:BSU05230" /db_xref="EnsemblGenomes-Tr:CAB12330" /db_xref="GOA:P96668" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12138" /db_xref="UniProtKB/Swiss-Prot:P96668" /translation="MNKTTNGWINGFIGVLIFSGSLPATRLAVSDFDPLFLTVCRAAI AGVLAGGLLLIFRQQHPAKRDLISLLVVAFGVVIGFPLLTALALQHVTSAHAIVFIGL LPLATAVFGVLRGGERPRPVFWIFSAAGSLLVAGFALIQGGGSSPLGDAYMLASIVVC GLGYAEGAKLSRRLGNWQVISWALVLSLPLMLPLSFFFTPDSWSAIGVPALLSLAYVS LFSMLIGFVFWYRGLAQGGIAAVGQLQLLQPFFGLLLASVILHEKVGWALVAVNIAVI MCVAAARRFAK*" /label="ydeK CDS" gene complement(531428..532291) /gene="ydeK" /locus_tag="BSU_05230" /old_locus_tag="BSU05230" /label="ydeK gene" promotor_-35 532334..532340 /Source="Nicolas_upshift_promotors" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 532355..532374 /Source="Nicolas_upshift_promotors" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(532356..532375) /Source="Nicolas_upshift_promotors" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 532370 /Source="Nicolas_upshifts" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(532380) /Source="Nicolas_upshifts" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(532390..532397) /Source="Nicolas_upshift_promotors" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 532446..533837 /gene="ydeL" /locus_tag="BSU_05240" /old_locus_tag="BSU05240" /function="16.3: Control" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388405.1" /db_xref="EnsemblGenomes-Gn:BSU05240" /db_xref="EnsemblGenomes-Tr:CAB12331" /db_xref="GOA:P96669" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12139" /db_xref="UniProtKB/Swiss-Prot:P96669" /translation="MDITPFLNRTLDIPLYQQLYRYFKENMHRGRIQKGMKLPSKRLL ANQLSISQTTVERAYEQLAAEGYIVSKPRSGWFADYHDSDFAYDRMPSTTPIQQEAEE NKQWIDFHYGNVDSSYFPFSAWRKSMVNSLDQYGHELYRPGHVLGEFELRTLIAEYLY QSRGVHCGPEQVIIGAGNPILLQILCQVFEPNISIGYEDPGYPRARKIFEANRMNIVP IPVDDEGICIQKIKEQQPNLVYVTPSHQFTLGTIMTINRRIQLLKWAAENQSFIIEDD YDGEFRYTGQPVPSLQGLDQHNRVIYMGTFSKSLLPSLRISYMILPSPLLKKGHEITS LYKQTVSCHSQLTLAEFIKNGEWQKHINRMRKLYRKKRAIVLEAVQRELGEHVRIRGE NSGLRILLDVYLPFGEKELIEKAKKHGVKIYPVSLSYQHHPPTKTVSLGFAGVSESDI REGIKKLKAAWKI*" /label="ydeL CDS" gene 532446..533837 /gene="ydeL" /locus_tag="BSU_05240" /old_locus_tag="BSU05240" /label="ydeL gene" promotor_-35 533965..533972 /Source="Nicolas_upshift_promotors" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="promotor_-35" promotor_-10 533983..534002 /Source="Nicolas_upshift_promotors" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="promotor_-10" upshifts 533997 /Source="Nicolas_upshifts" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="upshifts" CDS 534031..534456 /gene="ydeM" /locus_tag="BSU_05250" /old_locus_tag="BSU05250" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1556068, 26349822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydratase" /protein_id="NP_388406.1" /db_xref="EnsemblGenomes-Gn:BSU05250" /db_xref="EnsemblGenomes-Tr:CAB12332" /db_xref="InterPro:IPR002539" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG12140" /db_xref="UniProtKB/Swiss-Prot:P96670" /translation="MKLDEFTIGQVFKTKSLKVSKDDIMRFAGEFDPQYMHVDEEKAS KGRFNGIIASGIQTLAISFKLWIEEGFYGDDIIAGTEMNHMTFIKPVYPDDELFTIVE VLDKQPKRNELGILTVLLSTYNQKEVKVFEGELSVLIKR*" /label="ydeM CDS" gene 534031..534456 /gene="ydeM" /locus_tag="BSU_05250" /old_locus_tag="BSU05250" /label="ydeM gene" S_feature 534457..535711 /Source="Nicolas_S_feature" /locus_tag="new_573400_574654" /HighExp="G135, H2O2, G150, HiOs, G180, Cold, Paraq, UNK1, MG 15, LBGexp" /AntisenseName="ydeN" /AntisenseCor="0.40423774227585801" /AntisenseRegPval="-11.3" /CDS_PredictionProba="0.127641" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S183" CDS complement(534509..535081) /gene="ydeN" /locus_tag="BSU_05260" /old_locus_tag="BSU05260" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15159570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alpha/beta hydrolase" /protein_id="NP_388407.1" /db_xref="EnsemblGenomes-Gn:BSU05260" /db_xref="EnsemblGenomes-Tr:CAB12333" /db_xref="GOA:P96671" /db_xref="InterPro:IPR010662" /db_xref="InterPro:IPR029058" /db_xref="PDB:1UXO" /db_xref="SubtiList:BG12141" /db_xref="UniProtKB/Swiss-Prot:P96671" /translation="MTKQVYIIHGYRASSTNHWFPWLKKRLLADGVQADILNMPNPLQ PRLEDWLDTLSLYQHTLHENTYLVAHSLGCPAILRFLEHLQLRKQLGGIILVSGFAKS LPTLQMLDEFTQGSFDHQKIIESAKHRAVIASKDDQIVPFSFSKDLAQQIDAALYEVQ HGGHFLEDEGFTSLPIVYDVLTSYFSKETR*" /label="ydeN CDS" gene complement(534509..535081) /gene="ydeN" /locus_tag="BSU_05260" /old_locus_tag="BSU05260" /label="ydeN gene" downshifts complement(534514) /Source="Nicolas_upshifts" /id="D250" /incds=0 /nref=16 /ntot=160 /MaxReadThrough="1.96868" /MaxDrop="3.80195" /score="2.50673989" /energy="-11.3" /TU="NA" /idTUdmin="U407" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(535082..535162) /Source="Nicolas_S_feature" /locus_tag="new_574025_574105_c" /HighExp="dia15, dia5, Diami, Etha, LPhT, Lbtran, Heat, H2O2, Sw, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.955" /TUlongSig="NA" /TUlongPSig="NA" /label="S184" CDS complement(535163..535492) /gene="ydzF" /locus_tag="BSU_05270" /old_locus_tag="BSU05270" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388408.1" /db_xref="EnsemblGenomes-Gn:BSU05270" /db_xref="EnsemblGenomes-Tr:CAB12334" /db_xref="GOA:O31494" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12809" /db_xref="UniProtKB/Swiss-Prot:O31494" /translation="MNSLCRSKQAPFEYTLSLIGGKWKMRILYELGCEKTMRYGELKR AMPFITHKMLSAQLKELQTDGLIHRSEVSHTPLKVEYSLSDRGRSLYPLIDEMCKWGM AQGGPHM*" /label="ydzF CDS" gene complement(535163..535492) /gene="ydzF" /locus_tag="BSU_05270" /old_locus_tag="BSU05270" /label="ydzF gene" misc_feature complement(535509..535528) /Source="Nicolas_upshift_promotors" /id="U407" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig="0.955044955044955" /xcortree=1959 /SigmaFactorBS="cctttcacttcagatcgtgaatcgccctcaaacttcaacacc gaaaatcctaatttatTCTGATATGATACTTAAAAAaggaggtttgattacaatgaat a" /listShort="ydzF, S184, ydeN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(535526) /Source="Nicolas_upshifts" /id="U407" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig="0.955044955044955" /xcortree=1959 /SigmaFactorBS="cctttcacttcagatcgtgaatcgccctcaaacttcaacacc gaaaatcctaatttatTCTGATATGATACTTAAAAAaggaggtttgattacaatgaat a" /listShort="ydzF, S184, ydeN" /GFF_Attribute="listLong" /label="upshifts" misc_feature 535700..535719 /Source="Nicolas_upshift_promotors" /id="U408" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78021978021978" /psig=1 /xcortree=2345 /SigmaFactorBS="agttactttatttaaaaaaacgcatgtttttagctgaaaata tctatTATGGTATATTTAAATATAAagaaatatttgagaaatgaggaatggtatgaat a" /listShort="ydeO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 535713 /Source="Nicolas_upshifts" /id="U408" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78021978021978" /psig=1 /xcortree=2345 /SigmaFactorBS="agttactttatttaaaaaaacgcatgtttttagctgaaaata tctatTATGGTATATTTAAATATAAagaaatatttgagaaatgaggaatggtatgaat a" /listShort="ydeO" /GFF_Attribute="listLong" /label="upshifts" CDS 535747..536619 /gene="ydeO" /locus_tag="BSU_05280" /old_locus_tag="BSU05280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388409.1" /db_xref="EnsemblGenomes-Gn:BSU05280" /db_xref="EnsemblGenomes-Tr:CAB12335" /db_xref="GOA:P96672" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG12142" /db_xref="UniProtKB/Swiss-Prot:P96672" /translation="MNTPKKHKKFKAKMILQIIMVIIGGIIAAYGLETVLIPNSVSDG GVTGLSIVGSQLFNLPLGILIAVINIPFVWLGYKQIGKSFALLSIIGIVSLAAGTSFF HHTPAIIEGDTLLITVVGGIILGFGMGLALRNGGALDGIDMLAVLLSRKLPFGTSDLI LFLNLFVFIFVSTVFGLQGALLSVIAYYIASKVIHVVEEGLSGSKTFQIITTQPELMV ETIRDQLGRSATYKEAYGGFSHEKFKEITCVINRLEETKLKEIINDIDKTAFVTVYDV AEVKGSNFRNLNHH*" /label="ydeO CDS" gene 535747..536619 /gene="ydeO" /locus_tag="BSU_05280" /old_locus_tag="BSU05280" /label="ydeO gene" downshifts 536506 /Source="Nicolas_upshifts" /id="D251" /incds=1 /nref=7 /ntot=181 /MaxReadThrough="3.84278" /MaxDrop="2.68681" /score="15.0132064" /energy="-12.2" /TU="U408" /idTUdmin="U408" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" downshifts 536704 /Source="Nicolas_upshifts" /id="D252" /incds=0 /nref=54 /ntot=208 /MaxReadThrough="1.19842" /MaxDrop="3.77294" /score="15.0132064" /energy="-12.2" /TU="NA" /idTUdmin="U408" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(536769..537155) /gene="ydeP" /locus_tag="BSU_05290" /old_locus_tag="BSU05290" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388410.1" /db_xref="EnsemblGenomes-Gn:BSU05290" /db_xref="EnsemblGenomes-Tr:CAB12336" /db_xref="GOA:P96673" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12143" /db_xref="UniProtKB/Swiss-Prot:P96673" /translation="MRNRKLGIDYSSDDFEGCPVETTLDIIGGKWKGILLYHLIDGKK RFNEFRKLYPKITQRMLTLQLRELERDGVIHREVYKQVPPKVEYSLTEFGRTLEPVIL HMKDWGEKYKDRIDKLEAARKAEDKI*" /label="ydeP CDS" gene complement(536769..537155) /gene="ydeP" /locus_tag="BSU_05290" /old_locus_tag="BSU05290" /label="ydeP gene" downshifts complement(536781) /Source="Nicolas_upshifts" /id="D253" /incds=0 /nref=29 /ntot=191 /MaxReadThrough="0.85093" /MaxDrop="4.4837" /score="-9.3516261" /energy="-12.9" /TU="NA" /idTUdmin="U409" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature complement(537156..537220) /Source="Nicolas_S_feature" /locus_tag="new_576099_576163_c" /HighExp="Diami, dia5, Salt, dia15, Etha, Heat, G180, HiOs, LBGexp, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S185" promotor_-35 537208..537215 /Source="Nicolas_upshift_promotors" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(537209..537228) /Source="Nicolas_upshift_promotors" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(537222) /Source="Nicolas_upshifts" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 537229..537248 /Source="Nicolas_upshift_promotors" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 537232 /Source="Nicolas_upshifts" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(537243..537250) /Source="Nicolas_upshift_promotors" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 537266..537859 /gene="ydeQ" /locus_tag="BSU_05300" /old_locus_tag="BSU05300" /EC_number="1.6.99.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)H oxidoreductase involved in regulating potassium efflux" /protein_id="NP_388411.1" /db_xref="EnsemblGenomes-Gn:BSU05300" /db_xref="EnsemblGenomes-Tr:CAB12337" /db_xref="GOA:P96674" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG12144" /db_xref="UniProtKB/Swiss-Prot:P96674" /translation="MDHMKTLVLVVHPNIESSRINKKWKEAVLSEPDVTVHDLYEKYR DQPIDVEFEQQQLLAHDRIVFQFPLYWYSSPPLLKQWFDEVFTFGWAHGPGGNKLKGK EWVTAMSIGSPEHSYQAGGYNLFSISELTKPFQASAHLVGMTYLPSFAEYRANTISDQ EIAESANRYVKHITNIELNPKVRLQRYLKQLESVDLT*" /label="ydeQ CDS" gene 537266..537859 /gene="ydeQ" /locus_tag="BSU_05300" /old_locus_tag="BSU05300" /label="ydeQ gene" CDS complement(538003..539190) /gene="ydeR" /locus_tag="BSU_05310" /old_locus_tag="BSU05310" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388412.1" /db_xref="EnsemblGenomes-Gn:BSU05310" /db_xref="EnsemblGenomes-Tr:CAB12338" /db_xref="GOA:P96675" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12145" /db_xref="UniProtKB/Swiss-Prot:P96675" /translation="MANGNKQAGQRISPSLTLLLATACGIIVANLYYAQPLVGLISKA IGLSPSGAGLIVTLTQIGYVAGLLFLVPLGDIIENKKLIVVSLLLSAAALTLTAFVKH GTLFLAAAFFVGLGSIAAQVLVPFASYLASDAARGRVVGNVMSGLLLGIMLSRPISSL VADIWGWNAIFALSAVVSVILAIVLSKVLPARKPTANTNYTALLGSMWKLLRTTPVLR RRAIYHAFVFGAFSLFWTTVPLLLSGPDFHFSQKAIALYALVGIAGAVTAPIGGRLAD RGLTRLATGIALGVVVVSLLLPLMIQSSSPVGITVLVAAAILLDMGVSANLVLSQRAI FSLAPEIRSRLNGLFMAIFFLGGAIGSSIGGWAYASGGWSTALWIGIAFPVIALLYFI TEK*" /label="ydeR CDS" gene complement(538003..539190) /gene="ydeR" /locus_tag="BSU_05310" /old_locus_tag="BSU05310" /label="ydeR gene" promotor_-35 539326..539330 /Source="Nicolas_upshift_promotors" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 539344 /Source="Nicolas_upshifts" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 539345..539364 /Source="Nicolas_upshift_promotors" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 539394..539990 /gene="ydeS" /locus_tag="BSU_05320" /old_locus_tag="BSU05320" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15944459; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388413.1" /db_xref="EnsemblGenomes-Gn:BSU05320" /db_xref="EnsemblGenomes-Tr:CAB12339" /db_xref="GOA:P96676" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011075" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12146" /db_xref="UniProtKB/Swiss-Prot:P96676" /translation="MQSKRGRPRDEGTHKAILSAAYDLLLEKGFDAVTVDKIAERAKV SKATIYKWWSNKAAVIMDSFLSTATDRLPVPDTGSSVQDIVTHATNLARFLTSREGTV IKELIGAGQLDEKLAEEYRTRFFQPRRLQAKGLLEKGIQKGELRENLDIEVSIDLIYG PIFYRLLITGDEVNDSYVRDLVMNAFKGVQATSATESM*" /label="ydeS CDS" gene 539394..539990 /gene="ydeS" /locus_tag="BSU_05320" /old_locus_tag="BSU05320" /label="ydeS gene" CDS 540104..540289 /gene="ydzO" /locus_tag="BSU_05329" /old_locus_tag="BSU05329" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097684.1" /db_xref="EnsemblGenomes-Gn:BSU05329" /db_xref="EnsemblGenomes-Tr:CAX52555" /db_xref="UniProtKB/Swiss-Prot:C0H3V9" /translation="MSKKKSFNREYITSYYYIPFHRLEQGFYTSMEYRKVGVFKQQGK IDGHYVGVMAMEKILAM*" /label="ydzO CDS" gene 540104..540289 /gene="ydzO" /locus_tag="BSU_05329" /old_locus_tag="BSU05329" /label="ydzO gene" downshifts 540268 /Source="Nicolas_upshifts" /id="D254" /incds=0 /nref=5 /ntot=123 /MaxReadThrough="1.06987" /MaxDrop="2.89833" /score="-5.04743481" /energy="-6.3" /TU="NA" /idTUdmin="U411" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 540401..540404 /Source="Nicolas_upshift_promotors" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 540411..540597 /Source="Nicolas_S_feature" /locus_tag="new_579354_579540" /HighExp="LBGstat, G180, LBGexp, G135, Paraq, G150, Oxctl, dia0, Diami, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S186" upshifts 540411 /Source="Nicolas_upshifts" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 540419..540438 /Source="Nicolas_upshift_promotors" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 540598..540933 /gene="aseR" /locus_tag="BSU_05330" /old_locus_tag="BSU05330" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:15948947, 16430705" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15948947, 16430705; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (metals sensing ArsR-SmtB repressors family)" /protein_id="NP_388414.1" /db_xref="EnsemblGenomes-Gn:BSU05330" /db_xref="EnsemblGenomes-Tr:CAB12340" /db_xref="GOA:P96677" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12147" /db_xref="UniProtKB/Swiss-Prot:P96677" /translation="MTIDVAAMTRCLKTLSDQTRLIMMRLFLEQEYCVCQLVDMFEMS QPAISQHLRKLKNAGFVNEDRRGQWRYYSINGSCPEFDTLQLILHQIDQEDELLNHIK QKKTQACCQ*" /label="aseR CDS" gene 540598..540933 /gene="aseR" /locus_tag="BSU_05330" /old_locus_tag="BSU05330" /label="aseR gene" CDS 540946..542253 /gene="arsF" /locus_tag="BSU_05340" /old_locus_tag="BSU05340" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12950922, 14970228, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arsenite/antimonite/H+ antiporter" /protein_id="NP_388415.1" /db_xref="EnsemblGenomes-Gn:BSU05340" /db_xref="EnsemblGenomes-Tr:CAB12341" /db_xref="GOA:P96678" /db_xref="InterPro:IPR000802" /db_xref="SubtiList:BG12148" /db_xref="UniProtKB/Swiss-Prot:P96678" /translation="MTSMILAVFIFLLTLVLVIWQPKNLSIGWSACGGAVLALIAGVV NFHDVLTVTGIVWNATLAFVAIILISLILDNIGFFEWAALHMAKAAKGYGVRMFVYVS LLGAIVAALFANDGAALILTPIVLAMVRALHFNEKLVFPFIIASGFIADTTSLPFVVS NLVNIVSADYFHITFIDYASRMVVPYLFSLLASIIVLYLFFRKSIPKRYDLTEVKKPV EAIKDQNMFRLSWYILGLLLIGYFASEFFSIPVSVVAGSIAIIFLIAAQKSPAVHTKK VVKEAPWAIVFFSIGMYVVVYGVRNAGLTDVLSDVIQAAADQGLFAGTIGMGFIAAIL SSIMNNLPTVMIDALAIAGTDTHGMMREALIYANVIGSDLGPKITPIGSLATLLWLHV LSHKGMKISWGTYFKTGIILTIPTLLITLVGLYIWLLIIHSCF*" /label="arsF CDS" gene 540946..542253 /gene="arsF" /locus_tag="BSU_05340" /old_locus_tag="BSU05340" /label="arsF gene" CDS 542285..542389 /gene="ydzSn" /locus_tag="BSU_05343" /old_locus_tag="BSU05343" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; N-terminal part of ydzS" /translation="CTGNSCRSQMAEGWGRKYLGAKWNVYSAGIEAQG*" /label="ydzSn CDS" gene 542285..542389 /gene="ydzSn" /locus_tag="BSU_05343" /old_locus_tag="BSU05343" /pseudo /label="ydzSn gene" CDS 542398..542511 /gene="ydzSc" /locus_tag="BSU_05344" /old_locus_tag="BSU05344" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; C-terminal part of ydzS" /translation="AVKAMKEAGIDISNQTSEKFDDPAKAHGTEEVFPKGP*" /label="ydzSc CDS" gene 542398..542511 /gene="ydzSc" /locus_tag="BSU_05344" /old_locus_tag="BSU05344" /pseudo /label="ydzSc gene" promotor_-35 542697..542705 /Source="Nicolas_upshift_promotors" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 542716..542734 /Source="Nicolas_upshift_promotors" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 542733 /Source="Nicolas_upshifts" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 542751..543536 /gene="ydfB" /locus_tag="BSU_05350" /old_locus_tag="BSU05350" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388416.1" /db_xref="EnsemblGenomes-Gn:BSU05350" /db_xref="EnsemblGenomes-Tr:CAB12342" /db_xref="GOA:P96679" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR027365" /db_xref="SubtiList:BG12149" /db_xref="UniProtKB/Swiss-Prot:P96679" /translation="MSVLQELTKKKYSSLKTMFDDKYCPTFVYSILDQTIPGAVYADD QTFPKSFFIGTESGIYFIAGDQGNRDFHDFIAGYYEEQVKSSKRFTLFSSSDTWDSVL KPILKDDLNQMRRAAFSYQPKSFKKTLQLPKGLVLKRIDEDIISHSTAFNSAYYEEYW NSVSQFASKGFGFAVLHGNHVVSECTSIFLGHNRAEMDIYTLEEYRGLGLAYCVANRF IAFCMENGIVPSWDCDICNNSSIALAAKLGFKTVTEYTIYYSG*" /label="ydfB CDS" gene 542751..543536 /gene="ydfB" /locus_tag="BSU_05350" /old_locus_tag="BSU05350" /label="ydfB gene" downshifts 542798 /Source="Nicolas_upshifts" /id="D255" /incds=0 /nref=3 /ntot=24 /MaxReadThrough="2.67554" /MaxDrop="5.08398" /score="39.1565399" /energy="-19.2" /TU="NA" /idTUdmin="U413" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 543546 /Source="Nicolas_upshifts" /id="D256" /incds=0 /nref=2 /ntot=90 /MaxReadThrough="0.161840000000001" /MaxDrop="3.51451" /score="-0.169292431" /energy="-13.6" /TU="NA" /idTUdmin="U413" /TUdmin=748 /isTUend="FALSE" /label="downshifts" CDS complement(543593..544513) /gene="ydfC" /locus_tag="BSU_05360" /old_locus_tag="BSU05360" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid exporter" /protein_id="NP_388417.1" /db_xref="EnsemblGenomes-Gn:BSU05360" /db_xref="EnsemblGenomes-Tr:CAB12343" /db_xref="GOA:P96680" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12150" /db_xref="UniProtKB/Swiss-Prot:P96680" /translation="MRKKTVQIMISHSLMIGLWASAFPGIRAGLEGYTPEHLALFRLL IGSMALLLFAVLTQMRLPDLKDIPAIFLLGFLGFAFYHILLNIGEKTVSAGVASLLVT TAPIFSAMLSRLFYKEHFGFTKWLGSMISLLGVLLIAFGAGDFTYSMSGILVILLAAF SESIYFVFQARYIKKYGFIPFVTFTIWGGTIPMLVFLPGLGEEMMNASISATLSIVYL GLLPTVIPYFALAYVTSFVGASEATLSLYVTPALALIISWLWIGEIPTLLSLLGGVVT VGGVCFTYLKVNKMNKIFITHFSAKRVKKL*" /label="ydfC CDS" gene complement(543593..544513) /gene="ydfC" /locus_tag="BSU_05360" /old_locus_tag="BSU05360" /label="ydfC gene" CDS 544646..546094 /gene="ydfD" /locus_tag="BSU_05370" /old_locus_tag="BSU05370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388418.1" /db_xref="EnsemblGenomes-Gn:BSU05370" /db_xref="EnsemblGenomes-Tr:CAB12344" /db_xref="GOA:P96681" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12151" /db_xref="UniProtKB/Swiss-Prot:P96681" /translation="MSFPEEKKMKKLPKYRQIVHFIKEKIGNGEWPIGSKIPSQRTLA KDFQVNRSTVITALEELMADGLIEGTMGKGTVVINNTWTLMAKNSAPDWDQYVTSGIQ MPSRKIVQEINQSESNTDLIQLSKGELSAEIFPLAVMKEMMGKVSQHMEAFGYEEPKG YLPLREALSNYLKTIGINVSSSSILIVSGALQALQLISMGLLQRGSTVYLDQPSYLYS LHVFQSAGMKLTGLPMDNEGLLPENVHLTRGERGRAILYTNPCFHNPTGILMSKKRRE EILAVSENTQLPIIEDDIYRELWIDEIPPYPIKTIDKNGHVLYIGSLSKTLSPGLRIG WIVGPEPVIERLSDIKMQTDYGSSSLSQRVAAEWFTSGHYQQHVEKVRQQLKVRRELA LSALETHLKEVATWNIPKGGFFVWIKILPSISMKLLYTKALSKGILINLGSIYAQEKG NYIRLSYAYASLEDLQKGIYELGLMIKELASR*" /label="ydfD CDS" gene 544646..546094 /gene="ydfD" /locus_tag="BSU_05370" /old_locus_tag="BSU05370" /label="ydfD gene" CDS complement(546212..546835) /gene="ydfE" /locus_tag="BSU_05380" /old_locus_tag="BSU05380" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavoprotein" /protein_id="NP_388419.1" /db_xref="EnsemblGenomes-Gn:BSU05380" /db_xref="EnsemblGenomes-Tr:CAB12345" /db_xref="GOA:P96682" /db_xref="InterPro:IPR002563" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12152" /db_xref="UniProtKB/Swiss-Prot:P96682" /translation="MDIKKQDTRRFKEIKPKIMYYGTSTFLLTTLNEDGTTNISPMSS SWALGHYIILGVGLGGKAIDNLERHKECVINLPGPDLWENVERISSYSGKKSIPPLKK QIGFTYKKEKYEAAGLTPLQSKTVSPTRIKECPIQIEAEVKHIRLPEYESSFAIVETQ ALHFHAEESIILDENHINPSKWSPLIYNFRHYFGLGREVGKTFRSET*" /label="ydfE CDS" gene complement(546212..546835) /gene="ydfE" /locus_tag="BSU_05380" /old_locus_tag="BSU05380" /label="ydfE gene" promotor_-10 complement(546859..546878) /Source="Nicolas_upshift_promotors" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 546867..546874 /Source="Nicolas_upshift_promotors" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(546878) /Source="Nicolas_upshifts" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 546889..546908 /Source="Nicolas_upshift_promotors" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 546891 /Source="Nicolas_upshifts" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(546893..546899) /Source="Nicolas_upshift_promotors" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 546925..547605 /gene="ydfF" /locus_tag="BSU_05390" /old_locus_tag="BSU05390" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388420.1" /db_xref="EnsemblGenomes-Gn:BSU05390" /db_xref="EnsemblGenomes-Tr:CAB12346" /db_xref="GOA:P96683" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12153" /db_xref="UniProtKB/Swiss-Prot:P96683" /translation="MNPNIAKISSLLSDPSRSSILLSLMDGRIHPAGELAYLANIKPQ TASFHLNKLLEAKLISVEKHGRHRYYRLADSDAANVIEQLLHIAPKAKVKSLKESKEK KDLHFARTCYDHLAGYVGVQMAHSLVEQGMLKKVDLNFEVTSEGALFFSKLGINEEQQ RNKRRAFARCCLDWSERQHHIAGALGNALLVRMLEEEWIVRMPKTRAIRITQSGKIAF EKHLNVKI*" /label="ydfF CDS" gene 546925..547605 /gene="ydfF" /locus_tag="BSU_05390" /old_locus_tag="BSU05390" /label="ydfF gene" downshifts 547638 /Source="Nicolas_upshifts" /id="D257" /incds=0 /nref=113 /ntot=245 /MaxReadThrough="0.50202" /MaxDrop="4.24716" /score="-7.74889591" /energy="-4.5" /TU="U415" /idTUdmin="U415" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(547685..548128) /gene="ydfG" /locus_tag="BSU_05400" /old_locus_tag="BSU05400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388421.1" /db_xref="EnsemblGenomes-Gn:BSU05400" /db_xref="EnsemblGenomes-Tr:CAB12347" /db_xref="GOA:P96684" /db_xref="InterPro:IPR003779" /db_xref="InterPro:IPR004675" /db_xref="InterPro:IPR029032" /db_xref="SubtiList:BG12154" /db_xref="UniProtKB/Swiss-Prot:P96684" /translation="MSQRVSYYEIAPEGMKIMMDMEKYTKQSSINRTTRELIKIRVSQ MNGCAFCIDMHTSDARKMGETEQRIYCLHAWNECDFYSPEEKAALELSEHITLIPSKR VPDELYHRVREHYDEEQYVDLVLIINQINSWNRISIAMGNRAASK*" /label="ydfG CDS" gene complement(547685..548128) /gene="ydfG" /locus_tag="BSU_05400" /old_locus_tag="BSU05400" /label="ydfG gene" downshifts complement(547690) /Source="Nicolas_upshifts" /id="D258" /incds=0 /nref=10 /ntot=187 /MaxReadThrough="1.76648" /MaxDrop="3.73786" /score="0.225628164" /energy="-10.8" /TU="NA" /idTUdmin="U416" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(548151..548170) /Source="Nicolas_upshift_promotors" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(548175) /Source="Nicolas_upshifts" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(548184..548191) /Source="Nicolas_upshift_promotors" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(548214..548393) /gene="ydzP" /locus_tag="BSU_05408" /old_locus_tag="BSU05408" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097685.1" /db_xref="EnsemblGenomes-Gn:BSU05408" /db_xref="EnsemblGenomes-Tr:CAX52558" /db_xref="GOA:C0H3W0" /db_xref="UniProtKB/Swiss-Prot:C0H3W0" /translation="MNMYWFLGALLYFLIGTYIFIRVTRDSQSGSWILLALAAPLIIA GYPYFYSKKLLSKRR*" /label="ydzP CDS" gene complement(548214..548393) /gene="ydzP" /locus_tag="BSU_05408" /old_locus_tag="BSU05408" /label="ydzP gene" CDS complement(548390..548533) /gene="ydzQ" /locus_tag="BSU_05409" /old_locus_tag="BSU05409" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097686.1" /db_xref="EnsemblGenomes-Gn:BSU05409" /db_xref="EnsemblGenomes-Tr:CAX52559" /db_xref="UniProtKB/Swiss-Prot:C0H3W1" /translation="MKSIDLTILSLKRKGIRTEKVLKNQNPDRLSHMTDKNAQPKSKE KEE*" /label="ydzQ CDS" gene complement(548390..548533) /gene="ydzQ" /locus_tag="BSU_05409" /old_locus_tag="BSU05409" /label="ydzQ gene" promotor_-35 548484..548486 /Source="Nicolas_upshift_promotors" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 548502..548521 /Source="Nicolas_upshift_promotors" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 548518 /Source="Nicolas_upshifts" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 548801..550024 /gene="ydfH" /locus_tag="BSU_05410" /old_locus_tag="BSU05410" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15941986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15941986; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YdfI]" /protein_id="NP_388422.1" /db_xref="EnsemblGenomes-Gn:BSU05410" /db_xref="EnsemblGenomes-Tr:CAB12348" /db_xref="GOA:P96685" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12155" /db_xref="UniProtKB/Swiss-Prot:P96685" /translation="MLIRNPFKDKYYSHDRRALNMLALRVPGLAFILMIYIASIVLQF VSGGWSILLLYAFTILIAIFALLHWHSYRWVKKRVILYFAVQGLITFALANLMTGFFI LVIIGLYAFLIGQIIGMADRRRTFLILYLLLLLVINSAYHLHKGEVLHFIVIAAPIMI VIITYAATFFAQVDEKIKAQLTLERLELAHQQVEQLTLQNERQRMARDLHDTLAQGLV SLNMQLDAIHVHLAKGNTERAKEIIQQSMKRVKSTIADARSAIDDLRSKSEEIGVLKE RITSLMDHFIESTGMACLLDYRLHQVLDVRTAENCYYIIGECMTNAAKHAEAKTIWIS IWDDEKGRLHLTVKDNGKGFDVEKGKKKRGHYGLLGIQERVRAINGQFNIKSTKLKGT QIEITVPIQGEMQDE*" /label="ydfH CDS" gene 548801..550024 /gene="ydfH" /locus_tag="BSU_05410" /old_locus_tag="BSU05410" /label="ydfH gene" CDS 550017..550658 /gene="ydfI" /locus_tag="BSU_05420" /old_locus_tag="BSU05420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15941986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15941986; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YdfH]" /protein_id="NP_388423.1" /db_xref="EnsemblGenomes-Gn:BSU05420" /db_xref="EnsemblGenomes-Tr:CAB12349" /db_xref="GOA:P96686" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12156" /db_xref="UniProtKB/Swiss-Prot:P96686" /translation="MNKVLIVDDHLVVREGLKLLIETNDQYTIIGEAENGKVAVRLAD ELEPDIILMDLYMPEMSGLEAIKQIKEKHDTPIIILTTYNEDHLMIEGIELGAKGYLL KDTSSETLFHTMDAAIRGNVLLQPDILKRLQEIQFERMKKQRNETQLTEKEVIVLKAI AKGLKSKAIAFDLGVSERTVKSRLTSIYNKLGANSRTEAVTIAMQKGILTIDN*" /label="ydfI CDS" gene 550017..550658 /gene="ydfI" /locus_tag="BSU_05420" /old_locus_tag="BSU05420" /label="ydfI gene" downshifts 550652 /Source="Nicolas_upshifts" /id="D259" /incds=0 /nref=5 /ntot=147 /MaxReadThrough="1.15378" /MaxDrop="2.65603" /score="8.33575703" /energy="-6.4" /TU="NA" /idTUdmin="U419" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(550685..550704) /Source="Nicolas_upshift_promotors" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(550706) /Source="Nicolas_upshifts" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(550718..550725) /Source="Nicolas_upshift_promotors" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 550766..550771 /Source="Nicolas_upshift_promotors" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 550774..552948 /gene="ydfJ" /locus_tag="BSU_05430" /old_locus_tag="BSU05430" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15941986; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative proton metabolite efflux transporter" /protein_id="NP_388424.1" /db_xref="EnsemblGenomes-Gn:BSU05430" /db_xref="EnsemblGenomes-Tr:CAB12350" /db_xref="GOA:P96687" /db_xref="InterPro:IPR000731" /db_xref="InterPro:IPR004869" /db_xref="SubtiList:BG12157" /db_xref="UniProtKB/Swiss-Prot:P96687" /translation="MSKMLYTLGGWVARNRIKAICAWIVVLVAAIGLAVTLKPSFSED MSIPDTPSEKAMDVIQKEFPHGPDKGSIRVIFGAGDGEKLTGKPAKKAIEDTFKEISK DDSVDSIASPFVTGTIAKDGTVAYADIQYKSSADDIKDYSIKHLKDSLKMADDEGLQT ELSGDVPGAEMEIGGVSEIVGIILAFVVLAITFGSLLIAGLPILTALIGLGVSIGLVL IGTQVFDIASVSLSLAGMIGLAVGIDYALFIFTKHRQFLGEGIQKNESIARAVGTAGS AVVFAGLTVIVALCGLTVVNIPFMSAMGLTAGLSVLMAVLASITLVPAVLSIAGKRMI PKSNKKIEKQSTETNVWGRFVTKNPIMLSVCSILILIVISIPSMHLELGLPDAGMKAK DNPDRRAYDLLAEGFGEGFNGQLTIVADATNATENKAEAFADAVKEIKGLDHVASVTP AMPNKEGNFAIITVVPETGPNDVTTKDLVHDVRSLSDKNGVDLLVTGSTAVNIDISDR LNDAIPVFAVLIVGFAFVLLTIVFRSLLVPLVAVAGFMLTMTATLGICVFVLQDGNLI DFFKIPEKGPILAFLPILSIGILFGLAMDYQVFLVSRMREEYVKTNNPVQAIQAGLKH SGPVVTAAGLIMIFVFAGFIFAGEASIKANGLALSFGVLFDAFIVRMTLIPSVMKLMG NAAWYLPKWLDKIIPNVDIEGHQLTKEIQPEIDHEQKKQISV*" /label="ydfJ CDS" gene 550774..552948 /gene="ydfJ" /locus_tag="BSU_05430" /old_locus_tag="BSU05430" /label="ydfJ gene" upshifts 550784 /Source="Nicolas_upshifts" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 550786..550804 /Source="Nicolas_upshift_promotors" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(551850..551868) /Source="Nicolas_upshift_promotors" /id="U420" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=1205 /SigmaFactorBS="atgcatagatgggatactaatgacgatcaaaatcagaatgct GCATACACTTAGCATGATAggatttttggtgacaaagcgtccccagacatttgtttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(551850) /Source="Nicolas_upshifts" /id="U420" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=1205 /SigmaFactorBS="atgcatagatgggatactaatgacgatcaaaatcagaatgct GCATACACTTAGCATGATAggatttttggtgacaaagcgtccccagacatttgtttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(552952..553359) /Source="Nicolas_S_feature" /locus_tag="new_591895_592302_c" /HighExp="Paraq, H2O2, Oxctl, aero, LBGexp, dia15, GM 150, M/G, ferm, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S187" promotor_-35 552969..552973 /Source="Nicolas_upshift_promotors" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 552983 /Source="Nicolas_upshifts" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 552986..553005 /Source="Nicolas_upshift_promotors" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(552997) /Source="Nicolas_upshifts" /id="D260" /incds=0 /nref=22 /ntot=134 /MaxReadThrough="-0.100210000000001" /MaxDrop="3.637" /score="4.29161871" /energy="-8.8" /TU="NA" /idTUdmin="U422" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(553360..554262) /gene="cesA" /locus_tag="BSU_05440" /old_locus_tag="BSU05440" /EC_number="3.1.1.1" /function="16.8: Protect" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7765103, 22248594, 24418394" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7765103, 22248594, 24418394; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxylesterase NP" /protein_id="NP_388425.1" /db_xref="EnsemblGenomes-Gn:BSU05440" /db_xref="EnsemblGenomes-Tr:CAB12351" /db_xref="GOA:P96688" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="PDB:2R11" /db_xref="SubtiList:BG11957" /db_xref="UniProtKB/Swiss-Prot:P96688" /translation="MSNHSSSIPELSDNGIRYYQTYNESLSLWPVRCKSFYISTRFGQ THVIASGPEDAPPLVLLHGALFSSTMWYPNIADWSSKYRTYAVDIIGDKNKSIPENVS GTRTDYANWLLDVFDNLGIEKSHMIGLSLGGLHTMNFLLRMPERVKSAAILSPAETFL PFHHDFYKYALGLTASNGVETFLNWMMNDQNVLHPIFVKQFKAGVMWQDGSRNPNPNA DGFPYVFTDEELRSARVPILLLLGEHEVIYDPHSALHRASSFVPDIEAEVIKNAGHVL SMEQPTYVNERVMRFFNAETGISR*" /label="cesA CDS" gene complement(553360..554262) /gene="cesA" /locus_tag="BSU_05440" /old_locus_tag="BSU05440" /label="cesA gene" S_feature complement(554263..554358) /Source="Nicolas_S_feature" /locus_tag="new_593206_593301_c" /HighExp="nit, ferm, aero, LoTm, M/G, GM 150, Diami, Paraq, dia15, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S188" promotor_-10 complement(554338..554357) /Source="Nicolas_upshift_promotors" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(554358) /Source="Nicolas_upshifts" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(554371..554378) /Source="Nicolas_upshift_promotors" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(554464..555153) /gene="ydfK" /locus_tag="BSU_05450" /old_locus_tag="BSU05450" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10200972, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388426.1" /db_xref="EnsemblGenomes-Gn:BSU05450" /db_xref="EnsemblGenomes-Tr:CAB12352" /db_xref="GOA:P96689" /db_xref="InterPro:IPR007563" /db_xref="SubtiList:BG12158" /db_xref="UniProtKB/Swiss-Prot:P96689" /translation="MFGTIFNTVMIIAGSIIGGIFKKGIKDEYQDILMQAMGFAAVAL GINAITQHLPDSKYPILFIVSLAIGGLLGQIINLELRFNKLVNKFSKSNLAEGLSTAV LLFCIGSLSILGPVEAALHGDYTYLLTNGMLDGITSIVLASTFGFGIAAAALVLFSWQ GSIYLFAQVMESAINTDLINEITIVGGILILSSGLSILGIKKFKTLNLLPSLLIPPVV IFVIHAFGLRF*" /label="ydfK CDS" gene complement(554464..555153) /gene="ydfK" /locus_tag="BSU_05450" /old_locus_tag="BSU05450" /label="ydfK gene" CDS complement(555243..556055) /gene="ydfL" /locus_tag="BSU_05460" /old_locus_tag="BSU05460" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator of efflux transporter" /protein_id="NP_388427.1" /db_xref="EnsemblGenomes-Gn:BSU05460" /db_xref="EnsemblGenomes-Tr:CAB12353" /db_xref="GOA:P96690" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG12159" /db_xref="UniProtKB/Swiss-Prot:P96690" /translation="MKEFFSIGEVSKLFNVKISALRYYDEIGLLKPEYKDEQTNYRYY STQQFERLDTIKYLRALGLPINKLLDFYNSQNTNTLLHLLKSQQVEIDRKKKELERIE RKISRRITHIEDAVNMPLHQISKIKLPAMRVAYLQHEYVLGHDIEHSLAELRTHLNVN EDIFIGKIGLSISAANVKAKQFDKYSSIFMILEDENEKTSSEIIFPSREYLQIRFKGS HPEAEPYYKKLLAYMKEHHYEVAGDSIEITLIDYGITNNLDNYVTEILLPIK*" /label="ydfL CDS" gene complement(555243..556055) /gene="ydfL" /locus_tag="BSU_05460" /old_locus_tag="BSU05460" /label="ydfL gene" promotor_-10 complement(556084..556103) /Source="Nicolas_upshift_promotors" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(556097) /Source="Nicolas_upshifts" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(556119..556126) /Source="Nicolas_upshift_promotors" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(556166..557059) /gene="mneP" /locus_tag="BSU_05470" /old_locus_tag="BSU05470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="primary Mn(II) efflux pump" /protein_id="NP_388428.2" /db_xref="EnsemblGenomes-Gn:BSU05470" /db_xref="EnsemblGenomes-Tr:CAB12354" /db_xref="GOA:C0SP78" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG12160" /db_xref="UniProtKB/Swiss-Prot:C0SP78" /translation="MASEREQISRKVALIALIANLILMAGKVFFGLVGDSEAVFADGI HSAADVVASIAVLAVIGISNKPPDQDHPFGHGKAEVISEAIVGIILVIVSVYILIEAI LSFVKGPSVPQYSALFAALISYVAKEILYRYSIKQGKKWNSKAIIAIAYDHKGDIVAS LAAFIGVLLAIIGNSRGWSYLLYADAIASAIVAYLIFKISMELIRPSVDVLMEKSVDP ELIEEYKAVIFQCDQVKRIDRIRAREHGHYKLLDVRLSLDHDLTIKQGHDIAREIRNE IKRQFSDVEEVLIHVNPYFEE*" /label="mneP CDS" gene complement(556166..557059) /gene="mneP" /locus_tag="BSU_05470" /old_locus_tag="BSU05470" /label="mneP gene" downshifts complement(556186) /Source="Nicolas_upshifts" /id="D261" /incds=0 /nref=23 /ntot=121 /MaxReadThrough="1.07979" /MaxDrop="4.0938" /score="12.079524" /energy="-6.2" /TU="NA" /idTUdmin="U424" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(557060..557152) /Source="Nicolas_S_feature" /locus_tag="new_596003_596095_c" /HighExp="LPh, HPh, LPhT, UNK1, MG t5, MG 5, MG 15, BMM, GM 120, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S189" promotor_-10 complement(557133..557152) /Source="Nicolas_upshift_promotors" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(557150) /Source="Nicolas_upshifts" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(557168..557175) /Source="Nicolas_upshift_promotors" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 557341..557348 /Source="Nicolas_upshift_promotors" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 557363..557382 /Source="Nicolas_upshift_promotors" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 557369 /Source="Nicolas_upshifts" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="upshifts" CDS 557535..558155 /gene="ydfN" /locus_tag="BSU_05480" /old_locus_tag="BSU05480" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388429.1" /db_xref="EnsemblGenomes-Gn:BSU05480" /db_xref="EnsemblGenomes-Tr:CAB12355" /db_xref="GOA:P96692" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="PDB:3BEM" /db_xref="SubtiList:BG12161" /db_xref="UniProtKB/Swiss-Prot:P96692" /translation="MAEFTHLVNERRSASNFLSGHPITKEDLNEMFELVALAPSAFNL QHTKYVTVLDQDVKEKLKQAANGQYKVVSSSAVLLVLGDKQAYQQAADIYEGLKVLGI LNKQEYDHMVQDTVSFYENRGEQFKRDEAIRNASLSAMMFMLSAKEKGWDTCPMIGFD AEAVKRILNIDDQFEVVMMITIGKEKTESRRPRGYRKPVNEFVEYM*" /label="ydfN CDS" gene 557535..558155 /gene="ydfN" /locus_tag="BSU_05480" /old_locus_tag="BSU05480" /label="ydfN gene" promotor_-35 557879..557885 /Source="Nicolas_upshift_promotors" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 557890 /Source="Nicolas_upshifts" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 557899..557917 /Source="Nicolas_upshift_promotors" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 558171..559109 /gene="ydfO" /locus_tag="BSU_05490" /old_locus_tag="BSU05490" /EC_number="1.13.11.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dioxygenase" /protein_id="NP_388430.1" /db_xref="EnsemblGenomes-Gn:BSU05490" /db_xref="EnsemblGenomes-Tr:CAB12356" /db_xref="GOA:P96693" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="PDB:3OAJ" /db_xref="SubtiList:BG12162" /db_xref="UniProtKB/Swiss-Prot:P96693" /translation="MAKKTMGIHHITAIVGHPQENTDFYAGVLGLRLVKQTVNFDDPG TYHLYFGNEGGKPGTIITFFPWAGARQGVIGDGQVGVTSYVVPKGAMAFWEKRLEKFN VPYTKIERFGEQYVEFDDPHGLHLEIVEREEGEANTWTFGEVTPDVAIKGFGGATLLS EQPDKTADLLENIMGLERVGKEGDFVRYRSAGDIGNVIDLKLTPIGRGQMGAGTVHHI AWRANDDEDQLDWQRYIASHGYGVTPVRDRNYFNAIYFREHGEILFEIATDPPGFAHD ETQETMGEKLMLPVQYEPHRTQIEQGLLPFEVRELD*" /label="ydfO CDS" gene 558171..559109 /gene="ydfO" /locus_tag="BSU_05490" /old_locus_tag="BSU05490" /label="ydfO gene" promotor_-35 559097..559100 /Source="Nicolas_upshift_promotors" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 559115..559134 /Source="Nicolas_upshift_promotors" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 559122..559210 /Source="Nicolas_S_feature" /locus_tag="new_598065_598153" /HighExp="Etha, BT, S6, S7, S8, G/S, GM 10, Gly, GM 15, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB, SigA" /TUshortPSig="0.658, 0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S190" upshifts 559122 /Source="Nicolas_upshifts" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="upshifts" CDS 559211..559600 /gene="ydfP" /locus_tag="BSU_05500" /old_locus_tag="BSU05500" /EC_number="1.-.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15306018, 15849754, 16850406, 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane bound oxidoreductase" /protein_id="NP_388431.1" /db_xref="EnsemblGenomes-Gn:BSU05500" /db_xref="EnsemblGenomes-Tr:CAB12357" /db_xref="GOA:P96694" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG12163" /db_xref="UniProtKB/Swiss-Prot:P96694" /translation="MEDAGLLLIRIMIGVVFLFYGTQKLFGWFGGYGIKGTGQWFESI GVKPGNVAAALSGLGELVSGILFILGVFLPLGAAIITIIMLGAIVKVHGAKGFANGAG GFEYNLVLIAVSIGVALIGSGAYALHF*" /label="ydfP CDS" gene 559211..559600 /gene="ydfP" /locus_tag="BSU_05500" /old_locus_tag="BSU05500" /label="ydfP gene" downshifts 559591 /Source="Nicolas_upshifts" /id="D262" /incds=0 /nref=3 /ntot=91 /MaxReadThrough="1.0642" /MaxDrop="3.85597" /score="-8.69038499" /energy="-9.3" /TU="NA" /idTUdmin="U427" /TUdmin=29 /isTUend="FALSE" /label="downshifts" misc_feature 559714..559733 /Source="Nicolas_upshift_promotors" /id="U428" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.665334665334665" /psig="0.946053946053946" /xcortree=2048 /SigmaFactorBS="cattttcggcaagcttgcaggtactctgcaaagcaaaaaagc ggatatcataaatataAATCTGTATAGTGAATGATAcgtattgatgagcttggtcatg a" /listShort="S191, ydfQ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 559716..559785 /Source="Nicolas_S_feature" /locus_tag="new_598659_598728" /HighExp="Diami, dia5, H2O2, dia15, Etha, S8, Paraq, Salt, LPhT, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S191" upshifts 559716 /Source="Nicolas_upshifts" /id="U428" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.665334665334665" /psig="0.946053946053946" /xcortree=2048 /SigmaFactorBS="cattttcggcaagcttgcaggtactctgcaaagcaaaaaagc ggatatcataaatataAATCTGTATAGTGAATGATAcgtattgatgagcttggtcatg a" /listShort="S191, ydfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 559786..560124 /gene="ydfQ" /locus_tag="BSU_05510" /old_locus_tag="BSU05510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thioredoxin or thiol-disulfide isomerase" /protein_id="NP_388432.1" /db_xref="EnsemblGenomes-Gn:BSU05510" /db_xref="EnsemblGenomes-Tr:CAB12358" /db_xref="GOA:P96695" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12164" /db_xref="UniProtKB/Swiss-Prot:P96695" /translation="MKEMTGLHSLVSIENFIKQHKFSFIYISRPGCTVCHAVLPQLRI VLDQFPNIKLGHINADDVAEVAGRFSVFTVPVLLLFIDGTEFLREARFVHFEQLEQKL KRVYRLYEGE*" /label="ydfQ CDS" gene 559786..560124 /gene="ydfQ" /locus_tag="BSU_05510" /old_locus_tag="BSU05510" /label="ydfQ gene" downshifts 560112 /Source="Nicolas_upshifts" /id="D263" /incds=0 /nref=9 /ntot=28 /MaxReadThrough="1.76745" /MaxDrop="4.78737" /score="17.861178" /energy="-6" /TU="NA" /idTUdmin="U428" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(560164..560400) /gene="ydzH" /locus_tag="BSU_05520" /old_locus_tag="BSU05520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein, sporulation-related" /protein_id="NP_388433.1" /db_xref="EnsemblGenomes-Gn:BSU05520" /db_xref="EnsemblGenomes-Tr:CAB12359" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12810" /db_xref="UniProtKB/Swiss-Prot:O31496" /translation="MRSQINISNLTINGMTQNANTDIGQNLQNSHTANSKNYGVNFTL GDYSPSHSIIISASCDNDTSDQGQVDNPSSPSEE*" /label="ydzH CDS" gene complement(560164..560400) /gene="ydzH" /locus_tag="BSU_05520" /old_locus_tag="BSU05520" /label="ydzH gene" downshifts complement(560188) /Source="Nicolas_upshifts" /id="D264" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.87679" /MaxDrop="2.5881" /score="9.38580075" /energy="-6" /TU="NA" /idTUdmin="U430" /TUdmin=418 /isTUend="FALSE" /label="downshifts" promotor_-35 560212..560218 /Source="Nicolas_upshift_promotors" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 560233..560244 /Source="Nicolas_upshift_promotors" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 560244 /Source="Nicolas_upshifts" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(560401..560562) /Source="Nicolas_S_feature" /locus_tag="new_599344_599505_c" /HighExp="BT, B36, S8, S7, G135, S5, S6, G180, Pyr, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S192" S_feature complement(560566..560931) /Source="Nicolas_S_feature" /locus_tag="new_599509_599874_c" /HighExp="BT, B36, S8, S7, S6, G/S, S5, Pyr, B60, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigGF, SigK" /TUshortPSig="0.994, 0.989, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S193" downshifts complement(560606) /Source="Nicolas_upshifts" /id="D265" /incds=0 /nref=26 /ntot=52 /MaxReadThrough="2.64253" /MaxDrop="4.6761" /score="8.29803249" /energy="-12.4" /TU="NA" /idTUdmin="U430" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(560932..561162) /gene="ydzR" /locus_tag="BSU_05529" /old_locus_tag="BSU05529" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19383706, 20709900" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein, sporulation-related" /protein_id="YP_003097687.1" /db_xref="EnsemblGenomes-Gn:BSU05529" /db_xref="EnsemblGenomes-Tr:CAX52560" /db_xref="InterPro:IPR019618" /db_xref="UniProtKB/Swiss-Prot:C0H3W2" /translation="MMKFPVYIHSISGNSVFNNGFAVSISPFSVSKTTEGSGGSNTGL VFESNALSQTSSANQAQNVTYAIQELLSKLLA*" /label="ydzR CDS" gene complement(560932..561162) /gene="ydzR" /locus_tag="BSU_05529" /old_locus_tag="BSU05529" /label="ydzR gene" downshifts 561146 /Source="Nicolas_upshifts" /id="D266" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.08051" /MaxDrop="3.36374" /score="17.861178" /energy="-6" /TU="NA" /idTUdmin="U428" /TUdmin=1034 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(561183..561202) /Source="Nicolas_upshift_promotors" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(561200) /Source="Nicolas_upshifts" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(561202..561285) /Source="Nicolas_S_feature" /locus_tag="new_600145_600228_c" /HighExp="S8, S5, S7, S6, S4, nit, ferm, BT, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigK" /TUshortPSig="0.989, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S194" promotor_-35 complement(561216..561225) /Source="Nicolas_upshift_promotors" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(561286..561963) /gene="ydfR" /locus_tag="BSU_05530" /old_locus_tag="BSU05530" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_388434.1" /db_xref="EnsemblGenomes-Gn:BSU05530" /db_xref="EnsemblGenomes-Tr:CAB12360" /db_xref="GOA:P96696" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG12165" /db_xref="UniProtKB/Swiss-Prot:P96696" /translation="MNRLPFGYIKLRLAGRKANPMTNLIHHWSGGSMNFTWESLVLIV AGVILLRISGRKSIAQMTSTQTVVMISIGTIIVQPIIEYSLFKTLIAAAIFTSTLIVM EWIQMKSNTIEKMLTGKAKIVIENGQLHIENLKKMRLTADQLEMQLRLHGVTAIQDVK IATLEANGQLGIELTDDAKPLTVRDLKKLIHPDFINKDGQAQSGNQNIFDEVGKKNKK NVPKKLH*" /label="ydfR CDS" gene complement(561286..561963) /gene="ydfR" /locus_tag="BSU_05530" /old_locus_tag="BSU05530" /label="ydfR gene" promotor_-10 complement(561934..561945) /Source="Nicolas_upshift_promotors" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(561948) /Source="Nicolas_upshifts" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(561960..561966) /Source="Nicolas_upshift_promotors" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(561964..562797) /Source="Nicolas_S_feature" /locus_tag="new_600907_601740_c" /HighExp="S6, S8, S7, S5, BT, B36, G/S, Pyr, nit, B60" /AntisenseName="ydfS" /AntisenseCor="0.65823831974361602" /AntisenseRegPval="-34.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S195" promotor_-35 561979..561984 /Source="Nicolas_upshift_promotors" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 561999..562010 /Source="Nicolas_upshift_promotors" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 562004 /Source="Nicolas_upshifts" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="upshifts" CDS 562076..562783 /gene="ydfS" /locus_tag="BSU_05540" /old_locus_tag="BSU05540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388435.1" /db_xref="EnsemblGenomes-Gn:BSU05540" /db_xref="EnsemblGenomes-Tr:CAB12361" /db_xref="GOA:P96697" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG12166" /db_xref="UniProtKB/Swiss-Prot:P96697" /translation="MIELEVVIRTVASFGLLLIAERILGKQTISQMTIFDFIAAITLG AIAAGLAYNTSIKPHNMAISFSIFVLTIFLISFLSIKNRKLRKFFAGDPTVLIQNGKI LESNMRKMRYTLDYLNQQLREKEIFNIEEVLFAILETNGQLTVLRKPQFRHVTKQDLM IAVNQEQRLPIELIMDGEIIENNLKQNRLTESWLLEELRKRDIKVKETVYAVLLGNGD IYVDQYKDHISVPMDKE*" /label="ydfS CDS" gene 562076..562783 /gene="ydfS" /locus_tag="BSU_05540" /old_locus_tag="BSU05540" /label="ydfS gene" CDS complement(562798..563229) /gene="cotP" /locus_tag="BSU_05550" /old_locus_tag="BSU05550" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11150673" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11150673; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_388436.1" /db_xref="EnsemblGenomes-Gn:BSU05550" /db_xref="EnsemblGenomes-Tr:CAB12362" /db_xref="GOA:P96698" /db_xref="InterPro:IPR002068" /db_xref="InterPro:IPR008978" /db_xref="InterPro:IPR031107" /db_xref="SubtiList:BG12167" /db_xref="UniProtKB/Swiss-Prot:P96698" /translation="MDFEKIRKWLEITNEYKQSDFWTNVLKYKAPEHFFDSEASTFVY DFYQDEEYNFIIVEMPGVYEEELTIRLLSKTQLLIKGTITPVFPAEMEVLRERYYGEI ERIIQLPEAAETHLLQIQLLNGLLHISYPRQVETVAFNKGL*" /label="cotP CDS" gene complement(562798..563229) /gene="cotP" /locus_tag="BSU_05550" /old_locus_tag="BSU05550" /label="cotP gene" CDS complement(563242..563484) /gene="ydgA" /locus_tag="BSU_05560" /old_locus_tag="BSU05560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; putative germination protein" /protein_id="NP_388437.1" /db_xref="EnsemblGenomes-Gn:BSU05560" /db_xref="EnsemblGenomes-Tr:CAB12363" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12168" /db_xref="UniProtKB/Swiss-Prot:P96699" /translation="MPYQINIANIKINGVTQNGNIDVGPTVHNSHTANSKYFGANFSL GDLSPTSSLLNTGNIDSDVSDQDQIGNPSAPISNQI*" /label="ydgA CDS" gene complement(563242..563484) /gene="ydgA" /locus_tag="BSU_05560" /old_locus_tag="BSU05560" /label="ydgA gene" CDS complement(563498..563770) /gene="ydgB" /locus_tag="BSU_05570" /old_locus_tag="BSU05570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; putative germination protein" /protein_id="NP_388438.1" /db_xref="EnsemblGenomes-Gn:BSU05570" /db_xref="EnsemblGenomes-Tr:CAB12364" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12169" /db_xref="UniProtKB/Swiss-Prot:P96700" /translation="MPSTVINLYYLKINSISGNGSITIGEAAYNSPTNNQKSQGTNSS FGDTSPTESVMENFLNDPDVNDQTSIGNSDTSNVNAPPIAPPPILD*" /label="ydgB CDS" gene complement(563498..563770) /gene="ydgB" /locus_tag="BSU_05570" /old_locus_tag="BSU05570" /label="ydgB gene" promotor_-10 complement(563792..563811) /Source="Nicolas_upshift_promotors" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(563796) /Source="Nicolas_upshifts" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(563825..563834) /Source="Nicolas_upshift_promotors" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 563989..563996 /Source="Nicolas_upshift_promotors" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 564012..564031 /Source="Nicolas_upshift_promotors" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 564020 /Source="Nicolas_upshifts" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="upshifts" CDS 564069..564656 /gene="ydgC" /locus_tag="BSU_05580" /old_locus_tag="BSU05580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388439.1" /db_xref="EnsemblGenomes-Gn:BSU05580" /db_xref="EnsemblGenomes-Tr:CAB12365" /db_xref="GOA:P96701" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12170" /db_xref="UniProtKB/Swiss-Prot:P96701" /translation="MKSKGVESRKRLLKAAANEFSVRGFHDAKVSEIVKKAGFTQPSF YLYFQSKEAIFAELITDFHSRVRKLTESLLLENGLNTEDVSKRVLLAVETVFQFLDED KDLTKIGFFLNPEAKQMKKDLAMVLKENLEAEQRLGYFHSELDMETVAECLVGMIEHL TESFLLTGIKDPASLAAEVVNLLIYGMLPKGNDVR*" /label="ydgC CDS" gene 564069..564656 /gene="ydgC" /locus_tag="BSU_05580" /old_locus_tag="BSU05580" /label="ydgC gene" CDS 564653..564997 /gene="ydgD" /locus_tag="BSU_05590" /old_locus_tag="BSU05590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388440.1" /db_xref="EnsemblGenomes-Gn:BSU05590" /db_xref="EnsemblGenomes-Tr:CAB12366" /db_xref="GOA:P96702" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG12171" /db_xref="UniProtKB/Swiss-Prot:P96702" /translation="MISIMMKVSLAVFMLAGGIIKVSRVPFQVEHWRHYQYPLWFLTV TGILEIAGALAMTAGIWNRYAAIGAGVLFVVLMAGAIHAHMFRARQSVIMAIQAMICL IVSIMIIMGSYT*" /label="ydgD CDS" gene 564653..564997 /gene="ydgD" /locus_tag="BSU_05590" /old_locus_tag="BSU05590" /label="ydgD gene" S_feature 564998..565159 /Source="Nicolas_S_feature" /locus_tag="new_603941_604102" /HighExp="Salt, Diami, dia15, dia5, aero, H2O2, SMMPr, Etha, Lbtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S196" CDS 565160..565633 /gene="ydgE" /locus_tag="BSU_05600" /old_locus_tag="BSU05600" /EC_number="2.3.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388441.1" /db_xref="EnsemblGenomes-Gn:BSU05600" /db_xref="EnsemblGenomes-Tr:CAB12367" /db_xref="GOA:P96703" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12172" /db_xref="UniProtKB/Swiss-Prot:P96703" /translation="MAFTLEDMTEEEFEAFRGMSVQNFAKQNITSGTWTEKEAFEKSE QAYENMIPNGRDSSNHYFWNITNDQGERMGWLWLYADPLHPQKEAFIYSFGLYEAFRG KGLAQLALQTLDERARELGAERLALHVFAHNETAVYLYQKMGYAMTNIRMRKQLC*" /label="ydgE CDS" gene 565160..565633 /gene="ydgE" /locus_tag="BSU_05600" /old_locus_tag="BSU05600" /label="ydgE gene" S_feature 565634..566326 /Source="Nicolas_S_feature" /locus_tag="new_604577_605269" /HighExp="Salt, H2O2, dia15, aero, T-2.40H, Diami, T-3.40H, T-1.40H, T-4.40H, T-0.40H" /AntisenseName="vmlR" /AntisenseCor="-7.1224465259194999E-2" /AntisenseRegPval="-0.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S197" downshifts complement(565776) /Source="Nicolas_upshifts" /id="D267" /incds=0 /nref=4 /ntot=88 /MaxReadThrough="0.39199" /MaxDrop="3.39645" /score="18.2783449" /energy="-8.8" /TU="NA" /idTUdmin="U436" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(565793..567436) /gene="vmlR" /locus_tag="BSU_05610" /old_locus_tag="BSU05610" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16109936, 22226636, 24687494, 25891423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16109936, 22226636, 24687494, 25891423; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP-binding cassette efflux transporter" /protein_id="NP_388442.1" /db_xref="EnsemblGenomes-Gn:BSU05610" /db_xref="EnsemblGenomes-Tr:CAB12368" /db_xref="GOA:P39115" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG10767" /db_xref="UniProtKB/Swiss-Prot:P39115" /translation="MKEIVTLTNVSYEVKDQTVFKHVNASVQQGDIIGIIGKNGAGKS TLLHLIHNDLAPAQGQILRKDIKLALVEQETAAYSFADQTPAEKKLLEKWHVPLRDFH QLSGGEKLKARLAKGLSEDADLLLLDEPTNHLDEKSLQFLIQQLKHYNGTVILVSHDR YFLDEAATKIWSLEDQTLIEFKGNYSGYMKFREKKRLTQQREYEKQQKMVERIEAQMN GLASWSEKAHAQSTKKEGFKEYHRVKAKRTDAQIKSKQKRLEKELEKAKAEPVTPEYT VRFSIDTTHKTGKRFLEVQNVTKAFGERTLFKNANFTIQHGEKVAIIGPNGSGKTTLL NIILGQETAEGSVWVSPSANIGYLTQEVFDLPLEQTPEELFENETFKARGHVQNLMRH LGFTAAQWTEPIKHMSMGERVKIKLMAYILEEKDVLILDEPTNHLDLPSREQLEETLS QYSGTLLAVSHDRYFLEKTTNSKLVISNNGIEKQLNDVPSERNEREELRLKLETERQE VLGKLSFMTPNDKGYKELDQAFNELTKRIKELDHQDKKD*" /label="vmlR CDS" gene complement(565793..567436) /gene="vmlR" /locus_tag="BSU_05610" /old_locus_tag="BSU05610" /label="vmlR gene" S_feature complement(567471..567668) /Source="Nicolas_S_feature" /locus_tag="new_606414_606611_c" /HighExp="BC, Sw, B60, B36, LoTm, S7, HiOs, S4, BI, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S198" promotor_-35 567485..567487 /Source="Nicolas_upshift_promotors" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 567504..567522 /Source="Nicolas_upshift_promotors" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 567508 /Source="Nicolas_upshifts" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(567514) /Source="Nicolas_upshifts" /id="D268" /incds=0 /nref=210 /ntot=265 /MaxReadThrough="3.59768" /MaxDrop="6.27457" /score="29.5863709" /energy="-11.8" /TU="U436" /idTUdmin="U437" /TUdmin=242 /isTUend="FALSE" /label="downshifts" downshifts 567634 /Source="Nicolas_upshifts" /id="D269" /incds=0 /nref=35 /ntot=150 /MaxReadThrough="1.71902" /MaxDrop="4.95368" /score="-7.23582918" /energy="-13.3" /TU="NA" /idTUdmin="U435" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(567660..567679) /Source="Nicolas_upshift_promotors" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(567672) /Source="Nicolas_upshifts" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(567692..567699) /Source="Nicolas_upshift_promotors" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(567755) /Source="Nicolas_upshifts" /id="D270" /incds=0 /nref=92 /ntot=203 /MaxReadThrough="2.22553" /MaxDrop="5.71399" /score="18.9878298" /energy="-13.3" /TU="NA" /idTUdmin="U437" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(567756..569132) /gene="ydgF" /locus_tag="BSU_05620" /old_locus_tag="BSU05620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16109936, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_388443.1" /db_xref="EnsemblGenomes-Gn:BSU05620" /db_xref="EnsemblGenomes-Tr:CAB12369" /db_xref="GOA:P96704" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12173" /db_xref="UniProtKB/Swiss-Prot:P96704" /translation="MTDDMTKDNINQQTLQRGLKNRHIQLIAIGGAIGTGLFLGSGKS IHFAGPSILFAYMITGIICFLIMRSLGELLLSNLNYHSFVDFVQDYLGDMAAFITGWT YWFCWISIAMADLTAVGLYTQYWLPGVPQWVPGLIALIILLIMNLATVKLFGELEFWF ALIKVIAILALIVIGLVMIFKGFSTSSGVSSFTNLWSHGGLFPNGMHGFILSFQMVVF AFVGIELVGLTAGETENPEKVIPKAINNIPVRVLLFYIGALLVIMSIYPWDIINPSES PFVQVFVAVGIVGAASIINFVVLTSAASACNSAVFSTSRMVYSLAKDHNAPESMAKLT QRKVPRNALFFSAIVILIGVTLNYIMPEGVFTLITSISTVCFIYIWGITVICHMKYRK TRPELAKTNKFKLPLYPFTNYLILAFLAFVLVVLALAQDTRVSLFVTPVWFILLIVIY KVRKAKHQ*" /label="ydgF CDS" gene complement(567756..569132) /gene="ydgF" /locus_tag="BSU_05620" /old_locus_tag="BSU05620" /label="ydgF gene" misc_feature complement(569182..569201) /Source="Nicolas_upshift_promotors" /id="U437" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig=1 /xcortree=1890 /SigmaFactorBS="aatcacattaaaattcttttcatcaatccttttttagtaaaa aagatagaaattttAGTGTTATAATAATCATTAAaaatagattgctgactcaataaac a" /listShort="ydgF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(569197) /Source="Nicolas_upshifts" /id="U437" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig=1 /xcortree=1890 /SigmaFactorBS="aatcacattaaaattcttttcatcaatccttttttagtaaaa aagatagaaattttAGTGTTATAATAATCATTAAaaatagattgctgactcaataaac a" /listShort="ydgF" /GFF_Attribute="listLong" /label="upshifts" Polymorphism join(569271,569273) /Source="geneious" /ID="SNP_BsDelta6_608215_608214" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(A)5 -> (A)6" /Codon_Change /Coverage=41 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="A" /Variant_P_Value="8.2e-115" /Variant_Raw_Frequency=39 /comment="dinB_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" terminator 569272..569305 /created_by="User" /comment="dinB_terminator_improvement" /modified_by="User" /label="Delta6_dinB_Terminator" CDS complement(569304..569822) /gene="dinB" /locus_tag="BSU_05630" /old_locus_tag="BSU05630" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1847907, 3110138, 12644484, 16267290, 22059487; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nuclease inhibitor" /protein_id="NP_388444.1" /db_xref="EnsemblGenomes-Gn:BSU05630" /db_xref="EnsemblGenomes-Tr:CAB12370" /db_xref="GOA:Q02886" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG10539" /db_xref="UniProtKB/Swiss-Prot:Q02886" /translation="MSDFAFKLYEYNVWANQQIFNRLKELPKEIYHQEIQSVFPSISH VLSHVYLSDLGWIEVFSGKTLSDALALAEQLKEQTEAKEIEEMEDLFLRLSERYILFL QQKEQLNKPLQIQNPSSGIMKTTVSELLPHVVNHGTYHRGNITAMLRQAGYASAPTDY GLYLFMTKTEKA*" /label="dinB CDS" gene complement(569304..569822) /gene="dinB" /locus_tag="BSU_05630" /old_locus_tag="BSU05630" /label="dinB gene" downshifts complement(569318) /Source="Nicolas_upshifts" /id="D271" /incds=0 /nref=35 /ntot=176 /MaxReadThrough="2.77148" /MaxDrop="6.32316" /score="16.2748201" /energy="-15" /TU="NA" /idTUdmin="U438" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(569848..569867) /Source="Nicolas_upshift_promotors" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(569867) /Source="Nicolas_upshifts" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(569883..569886) /Source="Nicolas_upshift_promotors" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 569904..569911 /Source="Nicolas_upshift_promotors" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 569926..569945 /Source="Nicolas_upshift_promotors" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 569944 /Source="Nicolas_upshifts" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="upshifts" CDS complement(569956..570357) /gene="ydhUc" /locus_tag="PG10_BSU_05890_3'_ext" /locus_tag="BSU_05890" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="Mn catalase fragment; C-terminal part of YhdU" /db_xref="SubtiList:BG12198" /modified_by="User" /translation="FFQSSNFRGKQKQYRDLLRGIFLEEIAHVELVQNTINALLDESG GEGVGSQGTDQAPLDEAVKHANPHHYIIGAQSSLPVDAGGNPWNGSWVYNHGNLITDL LDNLLLESTGVLQKTRIYEMSSNQTHYSLPR*" /label="PG10_BSU_05890_3'_ext" CDS complement(569956..570084) /locus_tag="PG10_rand_002" /created_by="User" /transl_table=11 /pseudo /translation="MYNHGNLITDLLDNLLLESTGVLQKTRIYEMSSNQTHYSLPR*" /label="PG10_rand_002" gene complement(569956..570357) /gene="ydhUc" /locus_tag="PG10_BSU_05890_3'_ext" /old_locus_tag="BSU_05890" /pseudo /modified_by="User" /label="PG10_BSU_05890_3'_ext" gene complement(569956..570084) /locus_tag="PG10_rand_002" /created_by="User" /label="PG10_rand_002" CDS 569974..570066 /locus_tag="PG10_rand_001" /created_by="User" /transl_table=11 /pseudo /translation="MRLIRAHFINSCFLQHTCRLKKQVIQQVSN*" /label="PG10_rand_001" gene 569974..570066 /locus_tag="PG10_rand_001" /created_by="User" /modified_by="User" /label="PG10_rand_001" SCAR 569976..569977 /note="deletion occured in betwen marked nucleotides" /created_by="User" /label="IIG_Bs22" CDS complement(570288..570482) /gene="ydhUn" /locus_tag="BSU_05899" /old_locus_tag="BSU05899" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="Mn catalase fragment; N-terminal part of YhdU" /translation="MYYYKEELINIIKPDKPDPAAAKVLQEILGGHYGEMRTMMQFFS KALISEESRNSTAICFAAFF*" /label="ydhUn CDS" gene complement(570288..570482) /gene="ydhUn" /locus_tag="BSU_05899" /old_locus_tag="BSU05899" /pseudo /label="ydhUn gene" promotor_-10 complement(570515..570526) /Source="Nicolas_upshift_promotors" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(570523) /Source="Nicolas_upshifts" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(570540..570546) /Source="Nicolas_upshift_promotors" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 570601..570608 /Source="Nicolas_upshift_promotors" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 570622..570641 /Source="Nicolas_upshift_promotors" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-10" promotor_no_box 570624..570724 /Source="Nicolas_upshift_promotors" /id="U458" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.604395604395604" /psig="0.0919080919080919" /xcortree=1636 /SigmaFactorBS="gtatattattaaacgtcgctgatgaacagcgtgaaacaaaac agaaaaacaaaaaagttttcctaaggtgtttacaagattttaaaaatgtgtataataa g" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 570626 /Source="Nicolas_upshifts" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(570672) /Source="Nicolas_upshifts" /id="D286" /incds=0 /nref=1 /ntot=54 /MaxReadThrough="2.24619" /MaxDrop="4.20389" /score="11.9939391" /energy="-9" /TU="NA" /idTUdmin="U456" /TUdmin="-990" /isTUend="FALSE" /label="downshifts" upshifts 570684 /Source="Nicolas_upshifts" /id="U458" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.604395604395604" /psig="0.0919080919080919" /xcortree=1636 /SigmaFactorBS="gtatattattaaacgtcgctgatgaacagcgtgaaacaaaac agaaaaacaaaaaagttttcctaaggtgtttacaagattttaaaaatgtgtataataa g" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 570692..570699 /Source="Nicolas_upshift_promotors" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 570713..570732 /Source="Nicolas_upshift_promotors" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 570728..570815 /Source="Nicolas_S_feature" /locus_tag="new_635022_635109" /HighExp="LBGstat, C30, Cold, Heat, Oxctl, T-1.10H, T-0.40H, T-1.40H, UNK1, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.96, 0.0919, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S204" upshifts 570728 /Source="Nicolas_upshifts" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="upshifts" tRNA 570816..570892 /gene="trnE-Arg" /locus_tag="BSU_tRNA_79" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Arg tRNA" gene 570816..570892 /gene="trnE-Arg" /locus_tag="BSU_tRNA_79" /label="trnE-Arg gene" tRNA 570906..570979 /gene="trnE-Gly" /locus_tag="BSU_tRNA_80" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(UCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Gly tRNA" gene 570906..570979 /gene="trnE-Gly" /locus_tag="BSU_tRNA_80" /label="trnE-Gly gene" rRNA 571139..572693 /gene="rrnE-16S" /locus_tag="BSU_rRNA_30" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnE-16S rRNA" gene 571139..572693 /gene="rrnE-16S" /locus_tag="BSU_rRNA_30" /label="rrnE-16S gene" rRNA 572861..575788 /gene="rrnE-23S" /locus_tag="BSU_rRNA_12" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnE-23S rRNA" gene 572861..575788 /gene="rrnE-23S" /locus_tag="BSU_rRNA_12" /label="rrnE-23S gene" rRNA 575844..575960 /gene="rrnE-5S" /locus_tag="BSU_rRNA_13" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnE-5S rRNA" gene 575844..575960 /gene="rrnE-5S" /locus_tag="BSU_rRNA_13" /label="rrnE-5S gene" tRNA 575974..576050 /gene="trnE-Met" /locus_tag="BSU_tRNA_21" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Met(CAU); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Met tRNA" gene 575974..576050 /gene="trnE-Met" /locus_tag="BSU_tRNA_21" /label="trnE-Met gene" tRNA 576111..576187 /gene="trnE-Asp" /locus_tag="BSU_tRNA_22" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asp(GUC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Asp tRNA" gene 576111..576187 /gene="trnE-Asp" /locus_tag="BSU_tRNA_22" /label="trnE-Asp gene" downshifts 576184 /Source="Nicolas_upshifts" /id="D287" /incds=0 /nref=38 /ntot=211 /MaxReadThrough="6.00554" /MaxDrop="5.14761" /score="7.63230089" /energy="-5.4" /TU="NA" /idTUdmin="U460" /TUdmin="-3784" /isTUend="FALSE" /label="downshifts" promotor_-35 576288..576292 /Source="Nicolas_upshift_promotors" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 576308..576327 /Source="Nicolas_upshift_promotors" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 576312 /Source="Nicolas_upshifts" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="upshifts" CDS 576368..577345 /gene="thiL" /locus_tag="BSU_05900" /old_locus_tag="BSU05900" /EC_number="2.7.4.16" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16291685, 26443755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine-monophosphate kinase" /protein_id="NP_388471.1" /db_xref="EnsemblGenomes-Gn:BSU05900" /db_xref="EnsemblGenomes-Tr:CAB12409" /db_xref="GOA:O05514" /db_xref="InterPro:IPR006283" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10693" /db_xref="UniProtKB/Swiss-Prot:O05514" /translation="MDEFDLIHSITPRTIHHSSVDVGIGDDAALYTAKHGVQEIVCVD TMVEDVHFKLHYSSPEDIGYKALAVNISDIAAMGGIPKFYLVSLAVPSKWTESEIKAM YEGMNELAKLYHMDLIGGDTVSTADKLVVTVTVIGEIEKGQACLRSLAKPNDIVFVTG EIGSSAAGLSLLLEETNPQNSSVETDYFIHRHKRPEPRVSVGRLCSIFKRAALNDVSD GLASELNEIAEASCVSIEIVESMLPIHSDLPKLHPNWKEWALFGGEDFELTGTVSNEE WEVLKQECAALHLPITKIGYVREKTKSKVILKTDQTSMILEKKGYNHFK*" /label="thiL CDS" gene 576368..577345 /gene="thiL" /locus_tag="BSU_05900" /old_locus_tag="BSU05900" /label="thiL gene" CDS 577360..577836 /gene="tsaE" /locus_tag="BSU_05910" /old_locus_tag="BSU05910" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 19246765, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 19246765, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; ADP binding protein" /protein_id="NP_388472.1" /db_xref="EnsemblGenomes-Gn:BSU05910" /db_xref="EnsemblGenomes-Tr:CAB12410" /db_xref="GOA:O05515" /db_xref="InterPro:IPR003442" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12199" /db_xref="UniProtKB/Swiss-Prot:O05515" /translation="MKQLKWRTVNPEETKAIAKLTAAFAKPGDVLTLEGDLGAGKTTF TKGFAEGLGITRIVNSPTFTIIKEYNDGVLPLYHMDVYRMEDESEDLGLDEYFHGQGV CLVEWAHLIEEQLPQERLQIVIKRAGDDEREITFTAVGNRYEMLCEELSRHDNISN*" /label="tsaE CDS" gene 577360..577836 /gene="tsaE" /locus_tag="BSU_05910" /old_locus_tag="BSU05910" /label="tsaE gene" CDS 577817..578506 /gene="tsaB" /locus_tag="BSU_05920" /old_locus_tag="BSU05920" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 20944216, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 20944216, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; protease involved in TsaD function" /protein_id="NP_388473.1" /db_xref="EnsemblGenomes-Gn:BSU05920" /db_xref="EnsemblGenomes-Tr:CAB12411" /db_xref="GOA:O05516" /db_xref="InterPro:IPR000905" /db_xref="InterPro:IPR022496" /db_xref="SubtiList:BG12200" /db_xref="UniProtKB/Swiss-Prot:O05516" /translation="MTILAIDTSNYTLGIALLREDTVIAEYITYLKKNHSVRAMPAVH SLLNDCDMAPQDLSKIVVAKGPGSYTGVRIGVTLAKTLAWSLDIPISAVSSLETLAAN GRHFDGLISPIFDARRGQVYTGLYQYKNGLLEQVVPDQNVMLADWLEMLKEKDRPVLF LGHDTSLHKQMIEDVLGTKGFIGTAAQHNPRPSELAFLGKEKEAADVHGLVPDYLRLA EAEAKWIESQK*" /label="tsaB CDS" gene 577817..578506 /gene="tsaB" /locus_tag="BSU_05920" /old_locus_tag="BSU05920" /label="tsaB gene" CDS 578516..578971 /gene="rimI" /locus_tag="BSU_05930" /old_locus_tag="BSU05930" /EC_number="2.3.1.267" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2828880; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein S18 alanine N-acetyltransferase" /protein_id="NP_388474.1" /db_xref="EnsemblGenomes-Gn:BSU05930" /db_xref="EnsemblGenomes-Tr:CAB12412" /db_xref="GOA:O05517" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR006464" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12201" /db_xref="UniProtKB/Swiss-Prot:O05517" /translation="MKTKAAVRNMRLEDIDHVYEIEASSFTSPWTKDSFYHELLENPY AHYLVIEKDGHLAGYCGIWIVMDDAQITNIAIKPEYRGQSLGETLFRSAVELCKEKDA RRLSLEVRVSNHPAQGLYKKFGMQPGGIRKNYYTDNGEDALIMWVTINE*" /label="rimI CDS" gene 578516..578971 /gene="rimI" /locus_tag="BSU_05930" /old_locus_tag="BSU05930" /label="rimI gene" CDS 578964..580004 /gene="tsaD" /locus_tag="BSU_05940" /old_locus_tag="BSU05940" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11073929, 12682299, 9743119, 20824107, 21625506, 21873492, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; glycation binding protein" /protein_id="NP_388475.1" /db_xref="EnsemblGenomes-Gn:BSU05940" /db_xref="EnsemblGenomes-Tr:CAB12413" /db_xref="GOA:O05518" /db_xref="InterPro:IPR000905" /db_xref="InterPro:IPR017860" /db_xref="InterPro:IPR017861" /db_xref="InterPro:IPR022450" /db_xref="SubtiList:BG12202" /db_xref="UniProtKB/Swiss-Prot:O05518" /translation="MSEQKDMYVLGIETSCDETAAAIVKNGKEIISNVVASQIESHKR FGGVVPEIASRHHVEQITLVIEEAFRKAGMTYSDIDAIAVTEGPGLVGALLIGVNAAK ALSFAYNIPLVGVHHIAGHIYANRLVEDIVFPALALVVSGGHTELVYMKEHGSFEVIG ETLDDAAGEAYDKVARTMGLPYPGGPQIDKLAEKGNDNIPLPRAWLEEGSYNFSFSGL KSAVINTLHNASQKGQEIAPEDLSASFQNSVIDVLVTKTARAAKEYDVKQVLLAGGVA ANRGLRAALEKEFAQHEGITLVIPPLALCTDNAAMIAAAGTIAFEKGIRGAYDMNGQP GLELTSYQSLTR*" /label="tsaD CDS" gene 578964..580004 /gene="tsaD" /locus_tag="BSU_05940" /old_locus_tag="BSU05940" /label="tsaD gene" downshifts 579968 /Source="Nicolas_upshifts" /id="D288" /incds=0 /nref=39 /ntot=222 /MaxReadThrough="3.15518" /MaxDrop="4.65228" /score="3.97936019" /energy="-10.1" /TU="NA" /idTUdmin="U460" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(580234..582162) /gene="ydiF" /locus_tag="BSU_05950" /old_locus_tag="BSU05950" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11916677, 16109936, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_388476.2" /db_xref="EnsemblGenomes-Gn:BSU05950" /db_xref="EnsemblGenomes-Tr:CAB12414" /db_xref="GOA:O05519" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032524" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12203" /db_xref="UniProtKB/Swiss-Prot:O05519" /translation="MMILQVNQLSKSFGADTILNNIKLEVRNRDRIAIVGRNGAGKST LLKIIAGQLSYEKGEIIKPKDITMGYLAQHTGLDSKLTIKEELLTVFDHLKAMEKEMR AMEEKMAAADPGELESIMKTYDRLQQEFKDKGGYQYEADVRSVLHGLGFSHFDDSTQV QSLSGGQKTRLALGKLLLTQPDLLILDEPTNHLDIDTLTWLEHYLQGYSGAILIVSHD RYFLDKVVNQVYEVSRAESKKYHGNYSAYLDQKAAQYEKDLKMYEKQQDEIAKLQDFV DRNLARASTTKRAQSRRKQLERMDVMSKPLGDEKSANFHFDITKQSGNEVLRVQDLTI SYENQPPLLTEVSFMLTRGESAALVGPNGIGKSTLLKTLIDTLKPDQGTISYGSNVSV GYYDQEQAELTSSKRVLDELWDEYPGLPEKEIRTCLGNFLFSGDDVLKPVHSLSGGEK ARLALAKLMLQKANFLILDEPTNHLDLDSKEVLENALIDYPGTLLFVSHDRYFINRIA TRVLELSSSHIEEYLGDYDYYTEKKTEQLELEKMNQQEETDKTPATVKSDSKRSYEEE KEWKKKERQRLRRIEEIETTVQTIEENISRNDELLCDPEVYQDHEKVQAIHADNEKLN QELESLLSEWEELSTEED*" /label="ydiF CDS" gene complement(580234..582162) /gene="ydiF" /locus_tag="BSU_05950" /old_locus_tag="BSU05950" /label="ydiF gene" downshifts complement(580251) /Source="Nicolas_upshifts" /id="D289" /incds=0 /nref=170 /ntot=266 /MaxReadThrough="1.32926" /MaxDrop="5.81869" /score="16.702581" /energy="-12.6" /TU="NA" /idTUdmin="U463" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" misc_feature 581914..581933 /Source="Nicolas_upshift_promotors" /id="U461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig="0.98901098901099" /xcortree=2080 /SigmaFactorBS="tccttttccattgcttttaagtggtcaaaaacagtcagcagc tcttctttTATGGTAAGCTTAGAATCCAagccagtatgctgggcgagatatcccattg t" /listShort="S205, S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 581924 /Source="Nicolas_upshifts" /id="U461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig="0.98901098901099" /xcortree=2080 /SigmaFactorBS="tccttttccattgcttttaagtggtcaaaaacagtcagcagc tcttctttTATGGTAAGCTTAGAATCCAagccagtatgctgggcgagatatcccattg t" /listShort="S205, S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="upshifts" S_feature 581926..582115 /Source="Nicolas_S_feature" /locus_tag="new_646220_646409" /HighExp="Diami, H2O2, dia5, Paraq, G135, G180, G150, Cold, dia15, BC" /AntisenseName="ydiF" /AntisenseCor="0.47406689574609401" /AntisenseRegPval="-15.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S205" promotor_-35 582080..582087 /Source="Nicolas_upshift_promotors" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 582101..582120 /Source="Nicolas_upshift_promotors" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 582117..582287 /Source="Nicolas_S_feature" /locus_tag="new_646411_646581" /HighExp="Diami, dia5, dia15, H2O2, Etha, G180, G150, Oxctl, Mt0, Paraq" /AntisenseName="ydiF" /AntisenseCor="0.63697451027099605" /AntisenseRegPval="-31.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S206" upshifts 582117 /Source="Nicolas_upshifts" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(582182..582201) /Source="Nicolas_upshift_promotors" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(582194) /Source="Nicolas_upshifts" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(582215..582222) /Source="Nicolas_upshift_promotors" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 582288..582800 /gene="moaC" /locus_tag="BSU_05960" /old_locus_tag="BSU05960" /EC_number="4.6.1.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10903949, 16632608, 18607082, 20606263, 25941396, 26575208; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="molybdenum cofactor biosynthesis protein C" /protein_id="NP_388477.1" /db_xref="EnsemblGenomes-Gn:BSU05960" /db_xref="EnsemblGenomes-Tr:CAB12415" /db_xref="GOA:O05520" /db_xref="InterPro:IPR002820" /db_xref="InterPro:IPR023045" /db_xref="InterPro:IPR036522" /db_xref="SubtiList:BG12204" /db_xref="UniProtKB/Swiss-Prot:O05520" /translation="MNGFSHFNEQGRAQMVDISEKSSTVRTAAAVSSVHMKNEVYEKI QSHDIGKGDVLAVAQVAGIMAAKQTSNIIPMCHPLSLSGVDISFDWKIKEAEVILHIK AQVKTKGSTGVEMEALTSASVCALTVYDMCKALDKGMVIGPTFLLEKTGGKNGDFKRE LSEYNLEDQK*" /label="moaC CDS" gene 582288..582800 /gene="moaC" /locus_tag="BSU_05960" /old_locus_tag="BSU05960" /label="moaC gene" CDS 582797..583444 /gene="rex" /locus_tag="BSU_05970" /old_locus_tag="BSU05970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15231791, 16207915, 17015645, 17322317, 18485070, 21402078, 23046954, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231791, 16207915, 17015645, 17322317, 18485070, 21402078, 23046954, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcription repressor of cydABCD and yjlC-ndh expression" /protein_id="NP_388478.1" /db_xref="EnsemblGenomes-Gn:BSU05970" /db_xref="EnsemblGenomes-Tr:CAB12416" /db_xref="GOA:O05521" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR009718" /db_xref="InterPro:IPR022876" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2VT2" /db_xref="PDB:2VT3" /db_xref="SubtiList:BG12205" /db_xref="UniProtKB/Swiss-Prot:O05521" /translation="MNKDQSKIPQATAKRLPLYYRFLKNLHASGKQRVSSAELSDAVK VDSATIRRDFSYFGALGKKGYGYNVDYLLSFFRKTLDQDEMTDVILIGVGNLGTAFLH YNFTKNNNTKISMAFDINESKIGTEVGGVPVYNLDDLEQHVKDESVAILTVPAVAAQS ITDRLVALGIKGILNFTPARLNVPEHIRIHHIDLAVELQSLVYFLKHYSVLEEIE*" /label="rex CDS" gene 582797..583444 /gene="rex" /locus_tag="BSU_05970" /old_locus_tag="BSU05970" /label="rex gene" promotor_no_box 583274..583374 /Source="Nicolas_upshift_promotors" /id="U464" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.386613386613387" /psig="0.386613386613387" /xcortree=511 /SigmaFactorBS="tccattacagacagattggtcgcattaggaatcaagggaatc cttaattttacgccggcccgtttgaatgtgccggaacacattcgaattcatcatatag a" /listShort="tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 583334 /Source="Nicolas_upshifts" /id="U464" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.386613386613387" /psig="0.386613386613387" /xcortree=511 /SigmaFactorBS="tccattacagacagattggtcgcattaggaatcaagggaatc cttaattttacgccggcccgtttgaatgtgccggaacacattcgaattcatcatatag a" /listShort="tatAY, tatCY" /GFF_Attribute="listLong" /label="upshifts" CDS 583466..583639 /gene="tatAY" /locus_tag="BSU_05980" /old_locus_tag="BSU05980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15187182, 19049517, 22041895, 22544248, 24652282, 26239117, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 19049517, 22041895, 22544248, 24652282, 26239117, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388479.1" /db_xref="EnsemblGenomes-Gn:BSU05980" /db_xref="EnsemblGenomes-Tr:CAB12417" /db_xref="GOA:O05522" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR006312" /db_xref="SubtiList:BG12206" /db_xref="UniProtKB/Swiss-Prot:O05522" /translation="MPIGPGSLAVIAIVALIIFGPKKLPELGKAAGDTLREFKNATKG LTSDEEEKKKEDQ*" /label="tatAY CDS" gene 583466..583639 /gene="tatAY" /locus_tag="BSU_05980" /old_locus_tag="BSU05980" /label="tatAY gene" CDS 583646..584410 /gene="tatCY" /locus_tag="BSU_05990" /old_locus_tag="BSU05990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11007775, 15187182, 15849754, 16850406, 19049517, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007775, 15187182, 15849754, 16850406, 19049517, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388480.1" /db_xref="EnsemblGenomes-Gn:BSU05990" /db_xref="EnsemblGenomes-Tr:CAB12418" /db_xref="GOA:O05523" /db_xref="InterPro:IPR002033" /db_xref="InterPro:IPR019820" /db_xref="SubtiList:BG12207" /db_xref="UniProtKB/Swiss-Prot:O05523" /translation="MTRMKVNQMSLLEHIAELRKRLLIVALAFVVFFIAGFFLAKPII VYLQETDEAKQLTLNAFNLTDPLYVFMQFAFIIGIVLTSPVILYQLWAFVSPGLYEKE RKVTLSYIPVSILLFLAGLSFSYYILFPFVVDFMKRISQDLNVNQVIGINEYFHFLLQ LTIPFGLLFQMPVILMFLTRLGIVTPMFLAKIRKYAYFTLLVIAALITPPELLSHMMV TVPLLILYEISILISKAAYRKAQKSSAADRDVSSGQ*" /label="tatCY CDS" gene 583646..584410 /gene="tatCY" /locus_tag="BSU_05990" /old_locus_tag="BSU05990" /label="tatCY gene" downshifts 584390 /Source="Nicolas_upshifts" /id="D290" /incds=0 /nref=151 /ntot=251 /MaxReadThrough="4.01237" /MaxDrop="6.80817" /score="19.4098216" /energy="-12.7" /TU="NA" /idTUdmin="U461" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(584448..584639) /gene="ydiK" /locus_tag="BSU_06000" /old_locus_tag="BSU06000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388481.1" /db_xref="EnsemblGenomes-Gn:BSU06000" /db_xref="EnsemblGenomes-Tr:CAB12419" /db_xref="GOA:O05524" /db_xref="InterPro:IPR025426" /db_xref="SubtiList:BG12208" /db_xref="UniProtKB/Swiss-Prot:O05524" /translation="MRNPVVWGMIYFAVGCIFTYLAASSPGSMWSFYSILLMVFAAYN ISISFKMFAFSFKIKKNQK*" /label="ydiK CDS" gene complement(584448..584639) /gene="ydiK" /locus_tag="BSU_06000" /old_locus_tag="BSU06000" /label="ydiK gene" downshifts complement(584465) /Source="Nicolas_upshifts" /id="D291" /incds=0 /nref=211 /ntot=258 /MaxReadThrough="0.81338" /MaxDrop="6.43897" /score="25.5376889" /energy="-12.7" /TU="NA" /idTUdmin="U467" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(584636..585370) /gene="ydiL" /locus_tag="BSU_06010" /old_locus_tag="BSU06010" /EC_number="3.4.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane protease" /protein_id="NP_388482.1" /db_xref="EnsemblGenomes-Gn:BSU06010" /db_xref="EnsemblGenomes-Tr:CAB12420" /db_xref="GOA:O05525" /db_xref="InterPro:IPR003675" /db_xref="SubtiList:BG12209" /db_xref="UniProtKB/Swiss-Prot:O05525" /translation="MRKQYWFIILTYIIMQFSALIAIPLLFKFGYAGGQPTDENMLHA QGLWSVISFIACLVVVLLILRTVPKETLRNGQKDSIGLSILWAIAGFFIALFSQGIAG SIEYYVFGIGRESENTQAILDVIQAVPLMIIVSSIVGPILEEIIFRKIIFGALYEKTN FFFAGLISSVIFGIVHADLKHLLLYTAMGFTFAFLYARTKRIWVPIFAHLMMNTFVVI MQLEPVRNYLEQQSTQMQLIIGGLFL*" /label="ydiL CDS" gene complement(584636..585370) /gene="ydiL" /locus_tag="BSU_06010" /old_locus_tag="BSU06010" /label="ydiL gene" promotor_-35 585028..585033 /Source="Nicolas_upshift_promotors" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 585048..585066 /Source="Nicolas_upshift_promotors" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 585050 /Source="Nicolas_upshifts" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 585369..585370 /Source="Nicolas_upshift_promotors" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="promotor_-35" promotor_-10 585380..585394 /Source="Nicolas_upshift_promotors" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="promotor_-10" upshifts 585402 /Source="Nicolas_upshifts" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="upshifts" promotor_-10 complement(585407..585426) /Source="Nicolas_upshift_promotors" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 585424..585532 /Source="Nicolas_S_feature" /locus_tag="new_649718_649826" /HighExp="S4, S5, H2O2, S3, S8, S6, Diami, Oxctl, G180, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.238" /TUlongSig="NA" /TUlongPSig="NA" /label="S207" upshifts complement(585427) /Source="Nicolas_upshifts" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(585440..585445) /Source="Nicolas_upshift_promotors" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 585506..585512 /Source="Nicolas_upshift_promotors" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 585526..585545 /Source="Nicolas_upshift_promotors" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 585534..585608 /Source="Nicolas_S_feature" /locus_tag="new_649828_649902" /HighExp="HiTm, Etha, dia15, Heat, C90, dia5, LoTm, Lbexp, H2O2, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S208" upshifts 585534 /Source="Nicolas_upshifts" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="upshifts" CDS 585609..585893 /gene="groES" /locus_tag="BSU_06020" /old_locus_tag="BSU06020" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11407116, 17031040, 9303302" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11407116, 17031040, 9303302; Product type f: factor" /codon_start=1 /transl_table=11 /product="chaperonin small subunit" /protein_id="NP_388483.2" /db_xref="EnsemblGenomes-Gn:BSU06020" /db_xref="EnsemblGenomes-Tr:CAB12421" /db_xref="GOA:P28599" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR018369" /db_xref="InterPro:IPR020818" /db_xref="InterPro:IPR037124" /db_xref="SubtiList:BG10422" /db_xref="UniProtKB/Swiss-Prot:P28599" /translation="MLKPLGDRVVIELVESEEKTASGIVLPDSAKEKPQEGKIVAAGS GRVLESGERVALEVKEGDRIIFSKYAGTEVKYEGTEYLILRESDILAVIG*" /label="groES CDS" gene 585609..585893 /gene="groES" /locus_tag="BSU_06020" /old_locus_tag="BSU06020" /label="groES gene" CDS 585940..587574 /gene="groEL" /locus_tag="BSU_06030" /old_locus_tag="BSU06030" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9303302, 11407116, 17031040, 17420574, 22268681" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9303302, 11407116, 17031040, 17420574, 22268681; Product type f: factor" /codon_start=1 /transl_table=11 /product="chaperonin large subunit" /protein_id="NP_388484.1" /db_xref="EnsemblGenomes-Gn:BSU06030" /db_xref="EnsemblGenomes-Tr:CAB12422" /db_xref="GOA:P28598" /db_xref="InterPro:IPR001844" /db_xref="InterPro:IPR002423" /db_xref="InterPro:IPR018370" /db_xref="InterPro:IPR027409" /db_xref="InterPro:IPR027410" /db_xref="InterPro:IPR027413" /db_xref="SubtiList:BG10423" /db_xref="UniProtKB/Swiss-Prot:P28598" /translation="MAKEIKFSEEARRAMLRGVDALADAVKVTLGPKGRNVVLEKKFG SPLITNDGVTIAKEIELEDAFENMGAKLVAEVASKTNDVAGDGTTTATVLAQAMIREG LKNVTAGANPVGVRKGMEQAVAVAIENLKEISKPIEGKESIAQVAAISAADEEVGSLI AEAMERVGNDGVITIEESKGFTTELEVVEGMQFDRGYASPYMVTDSDKMEAVLDNPYI LITDKKITNIQEILPVLEQVVQQGKPLLLIAEDVEGEALATLVVNKLRGTFNAVAVKA PGFGDRRKAMLEDIAVLTGGEVITEDLGLDLKSTQIAQLGRASKVVVTKENTTIVEGA GETDKISARVTQIRAQVEETTSEFDREKLQERLAKLAGGVAVIKVGAATETELKERKL RIEDALNSTRAAVEEGIVSGGGTALVNVYNKVAAVEAEGDAQTGINIVLRALEEPIRQ IAHNAGLEGSVIVERLKNEEIGVGFNAATGEWVNMIEKGIVDPTKVTRSALQNAASVA AMFLTTEAVVADKPEENGGGAGMPDMGGMGGMGGMM*" /label="groEL CDS" gene 585940..587574 /gene="groEL" /locus_tag="BSU_06030" /old_locus_tag="BSU06030" /label="groEL gene" S_feature 587575..587667 /Source="Nicolas_S_feature" /locus_tag="new_651869_651961" /HighExp="HiTm, Etha, dia15, Heat, Diami, dia5, C90, S1, S2, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S209" downshifts 587624 /Source="Nicolas_upshifts" /id="D292" /incds=0 /nref=228 /ntot=267 /MaxReadThrough="6.24882" /MaxDrop="5.77437" /score="-6.71161833" /energy="-16.3" /TU="U468" /idTUdmin="U466" /TUdmin=2112 /isTUend="FALSE" /label="downshifts" CDS complement(587662..587790) /gene="ydzTc" /locus_tag="BSU_06033" /old_locus_tag="BSU06033" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); C-terminal part of YdzT; defective prophage 3" /translation="EAGVGIKEIQQQFGHSDINTTMDIYAHMTANMEKRSPNSLVN*" /label="ydzTc CDS" gene complement(587662..587790) /gene="ydzTc" /locus_tag="BSU_06033" /old_locus_tag="BSU06033" /pseudo /label="ydzTc gene" S_feature 587669..>588895 /Source="Nicolas_S_feature" /locus_tag="new_651963_653431" /HighExp="H2O2, Heat, dia15, Diami, S1, G135, G150, S2, G180, dia5" /AntisenseName="ydzT" /AntisenseCor="-2.9485116084752801E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="0.23100000000000001" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S210" CDS complement(587793..587951) /gene="ydzT" /locus_tag="BSU_06034" /old_locus_tag="BSU06034" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52563.1" /translation="MIYQDSSFIFEREDGHPQLRKVIETRLKRLLKKAGIKRMSPPTL LGIPIPPY*" /label="ydzT CDS" gene complement(587793..587951) /gene="ydzT" /locus_tag="BSU_06034" /old_locus_tag="BSU06034" /pseudo /label="ydzT gene" CDS complement(587996..588124) /gene="ydzT" /locus_tag="BSU_06036" /old_locus_tag="BSU06036" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52564.1" /translation="MISQVTKTLYTPNNQIEKYQLLTPKTTGSVDIVRIDETMSIY*" /label="ydzT CDS" gene complement(587996..588124) /gene="ydzT" /locus_tag="BSU_06036" /old_locus_tag="BSU06036" /pseudo /label="ydzT gene" CDS complement(588217..588426) /gene="ydzT" /locus_tag="BSU_06037" /old_locus_tag="BSU06037" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52565.1" /translation="MYEDRTLELNEQYSHNCLGGIHACGRMIFRKAKTQGIIKMNPTG DFQLPKKQQSIGKRGADTFSKARSI*" /label="ydzT CDS" gene complement(588217..588426) /gene="ydzT" /locus_tag="BSU_06037" /old_locus_tag="BSU06037" /pseudo /label="ydzT gene" CDS complement(588419..588724) /gene="ydzTn" /locus_tag="BSU_06038" /old_locus_tag="BSU06038" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); N-terminal part of YdzT; defective prophage 3" /db_xref="PSEUDO:CAX52566.1" /translation="MELSYLLGIDPLTKKRLEISKGRFKTKKEAPVAARHVELQNDNG TFIKESDMPFKTFAKGWLKIYNRSGVKISSVRASEKKMMHFIAVLGQYPISKTQKNV* " /label="ydzTn CDS" gene complement(588419..588724) /gene="ydzTn" /locus_tag="BSU_06038" /old_locus_tag="BSU06038" /pseudo /label="ydzTn gene" SCAR join(588895,588902) /created_by="AR/SM" /note="deletion occured in betwen marked nucleotides" /label="Delta6_1" N_region 588896..588901 /note="KpnI site (GGTACC)" /created_by="User" /label="Delta6_1" CDS complement(589000..591489) /gene="gutR" /locus_tag="BSU_06140" /old_locus_tag="BSU06140" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11118449, 11390381, 12897001" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11118449, 11390381, 12897001; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the glucitol operon" /protein_id="NP_388495.1" /db_xref="EnsemblGenomes-Gn:BSU06140" /db_xref="EnsemblGenomes-Tr:CAB12433" /db_xref="GOA:P39143" /db_xref="InterPro:IPR002182" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="InterPro:IPR024123" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10178" /db_xref="UniProtKB/Swiss-Prot:P39143" /translation="MAELENRKQFAQMLAPGVKTLKLHPDYKVRRKKNEKTGQSYIDK IALQLGVSPNTIKSWIGQMGANYIPGRIDDGKLFGMIWIILEKTDLDIEWLTDLLEAT TIPVIKPALPVWAASCLKKAKILRKDGLFGAPSEGEIENVVKRLFHDRPGQETNALTE QPITHNLPSRWSGRFIGRSFDMEAIRQWMLSPSPVCLITGWAGMGKTTIALEAAYSCV DDTSVWPAFNSIIWVSADWKGLSFSDFLNTIAYQLGRKEQIDKSINVKRFVVRNALAN YTREKPILLIVDSIDTAERDIHEFITSLPQGVKVLLTARENVKQTYRESFGEMTAIQL SGLDQTDAHEFFQQEVHHCLQTCNLPRKREKLEQLLHLSSDLKNEFISATAGNPKAMA LSIAYMSDDDIPAQQLIHELGKAGYSLLELFEFLFGRTWDRCNEDTRKLWQTLCFFSK PPDEKSLAAAAGLDARRFHYAMEQMRSYALIQPERSQGRTQYLAHQTVVAYGEQHLSE QHEYEKEARNRWAHYYIDYAETHLKREQPNSIYWSYLLGRNLDQMKQEWPNILKVIQW ASETEQKEILIELITRISHFLSRINLPLRIEYGRKAADAAHHLGQHTREAYFRIDTSG WALMEVNDLDGALQQIEAGLKILEQSDAHDAYDLKVWGHALKARLFLKDGQQEKAETI LNEIENQPISPTIQHRVLLVRGDLSFARGYHVEAIQLYEAANEISSTYGGEKTIEAYF NLGVAYVKCDQFEKAEEAFEQMLYDKHNANQVELIYYHYGMAQLLYRKGEKTKAVESN QKAIRLIDSWEPAIGIRGEVERLARATKENE*" /label="gutR CDS" gene complement(589000..591489) /gene="gutR" /locus_tag="BSU_06140" /old_locus_tag="BSU06140" /label="gutR gene" downshifts complement(589022) /Source="Nicolas_upshifts" /id="D298" /incds=0 /nref=56 /ntot=209 /MaxReadThrough="0.69715" /MaxDrop="4.256" /score="0.285109352" /energy="-13.9" /TU="NA" /idTUdmin="U474" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(591503..591522) /Source="Nicolas_upshift_promotors" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(591529) /Source="Nicolas_upshifts" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(591536..591543) /Source="Nicolas_upshift_promotors" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 591592..591593 /Source="Nicolas_upshift_promotors" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 591608..591690 /Source="Nicolas_S_feature" /locus_tag="new_667383_667465" /HighExp="Lbstat, BI, M40t90, Mt0, M0t90, dia5, dia0, Lbexp, Lbtran, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.848" /TUlongSig="NA" /TUlongPSig="NA" /label="S220" upshifts 591608 /Source="Nicolas_upshifts" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 591609..591628 /Source="Nicolas_upshift_promotors" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 591691..592752 /gene="gutB" /locus_tag="BSU_06150" /old_locus_tag="BSU06150" /EC_number="1.1.1.14" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1460002, 8195086, 8195087, 12897001, 19784641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1460002, 8195086, 8195087, 12897001, 19784641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucitol (sorbitol) dehydrogenase" /protein_id="NP_388496.1" /db_xref="EnsemblGenomes-Gn:BSU06150" /db_xref="EnsemblGenomes-Tr:CAB12434" /db_xref="GOA:Q06004" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10177" /db_xref="UniProtKB/Swiss-Prot:Q06004" /translation="MTHTVPQNMKAAVMHNTREIKIETLPVPDINHDEVLIKVMAVGI CGSDLHYYTNGRIGNYVVEKPFILGHECAGEIAAVGSSVDQFKVGDRVAVEPGVTCGR CEACKEGRYNLCPDVQFLATPPVDGAFVQYIKMRQDFVFLIPDSLSYEEAALIEPFSV GIHAAARTKLQPGSTIAIMGMGPVGLMAVAAAKAFGAGTIIVTDLEPLRLEAAKKMGA THIINIREQDALEEIKTITNDRGVDVAWETAGNPAALQSALASVRRGGKLAIVGLPSQ NEIPLNVPFIADNEIDIYGIFRYANTYPKGIEFLASGIVDTKHLVTDQYSLEQTQDAM ERALQFKNECLKVMVYPNR*" /label="gutB CDS" gene 591691..592752 /gene="gutB" /locus_tag="BSU_06150" /old_locus_tag="BSU06150" /label="gutB gene" CDS 592826..594217 /gene="gutP" /locus_tag="BSU_06160" /old_locus_tag="BSU06160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12897001, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="H+-glucitol symporter; prophage region 3" /protein_id="NP_388497.1" /db_xref="EnsemblGenomes-Gn:BSU06160" /db_xref="EnsemblGenomes-Tr:CAB12435" /db_xref="GOA:O34368" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12795" /db_xref="UniProtKB/Swiss-Prot:O34368" /translation="MIGTEKVTALKAKHQSKSSTGLSWFERIGYGFGDMSYNIIFQFV NAYLLFYYTDVGGIQPAVIATLFLVVRVLDAIFDPIMGLILDKTNTRWGKARPYLLWV AFPFALFTFLCFTTPHFGETGNMVYAYVTYILLGMSFSMQTIPVNSLTGRMTNSVEER TVLTTTRMILVYIGILLSISCATPLATAIGGEDQAFGFQMTALIYAAVSIVLNLFSFF TVRERIQPKKRKKQGIKKTLSVLFKNKPLLMLISSFLAFAIGFNIKLSTMVYYFTYNV NHKEFVFMGTVLFFGAALISNLFIPFFSEKWGRKQVMIITAALSLISYAGLHFTPYSS IPLIFIWLFASGFFTTPLNTLAWGMVADCVDYAEWKTGIRADGVVISSMSFINKLGVA LAGSFSAIYLGIAGYVANTDQTVASLNAIKNMNALIPGFFILLSIILIAFYPLTEKRY KHIISELEQRSAR*" /label="gutP CDS" gene 592826..594217 /gene="gutP" /locus_tag="BSU_06160" /old_locus_tag="BSU06160" /label="gutP gene" promotor_-35 594244..594251 /Source="Nicolas_upshift_promotors" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 594265..594284 /Source="Nicolas_upshift_promotors" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 594270 /Source="Nicolas_upshifts" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="upshifts" CDS 594312..595274 /gene="ydjE" /locus_tag="BSU_06170" /old_locus_tag="BSU06170" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26483775, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar kinase (ribokinase family); prophage region 3" /protein_id="NP_388498.1" /db_xref="EnsemblGenomes-Gn:BSU06170" /db_xref="EnsemblGenomes-Tr:CAB12436" /db_xref="GOA:O34768" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG12796" /db_xref="UniProtKB/Swiss-Prot:O34768" /translation="MRSHSVVCIGELLIDFFCTDVDVDLMEGRQFLKSAGGAPANVSA AIAKLGGDAAFSGKVGKDPFGYFLKRTLDAVHVDTSMLVMDEKAPTTLAFVSLKQNGE RDFVFNRGADALFTLEDIDQEKLNEAKILHFGSATALLSDPFCSAYLRLMSIAKDNGQ FISFDPNYREDLWRGRVSEFVSVAKKAIAVSDFVKVSDEELEIISGVKDHEKGVAILH EIGANIVAVTLGKSGTLLSNGKDREIIPSIPVTSIDSTGAGDAFVGAALYQLANTDQI QSVDADFVKLREIVAFANKVGALVCTKIGAIDALPSLDEIGVSL*" /label="ydjE CDS" gene 594312..595274 /gene="ydjE" /locus_tag="BSU_06170" /old_locus_tag="BSU06170" /label="ydjE gene" downshifts 595259 /Source="Nicolas_upshifts" /id="D299" /incds=0 /nref=86 /ntot=213 /MaxReadThrough="2.99546" /MaxDrop="4.52045" /score="16.4550614" /energy="-14" /TU="NA" /idTUdmin="U475" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 595399..595408 /Source="Nicolas_upshift_promotors" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 595415 /Source="Nicolas_upshifts" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 595421..595436 /Source="Nicolas_upshift_promotors" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 595470..596153 /gene="pspA" /locus_tag="BSU_06180" /old_locus_tag="BSU06180" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11454200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11454200; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage shock protein A homolog regulator; prophage region 3" /protein_id="NP_388499.1" /db_xref="EnsemblGenomes-Gn:BSU06180" /db_xref="EnsemblGenomes-Tr:CAB12437" /db_xref="GOA:P54617" /db_xref="InterPro:IPR007157" /db_xref="SubtiList:BG12797" /db_xref="UniProtKB/Swiss-Prot:P54617" /translation="MSIIGRFKDIMSANINALLDKAENPEKMVDQYLRNMNSDLAKVK AETAAVMAEEQRAKREYHECQADMEKMESYAMKALQAGNESDARKFLERKTSLESKLS ELQAANQIAATNAAQMRKMHDKLVSDIGELEARKNMIKAKWAVAKTQERMNKLGASVS STSQSMSAFGRMEDKVNKALDQANAMAELNSAPQDDMADLSAKYDTGGSSQVDDELAA LKAKMMLDK*" /label="pspA CDS" gene 595470..596153 /gene="pspA" /locus_tag="BSU_06180" /old_locus_tag="BSU06180" /label="pspA gene" S_feature 596154..596218 /Source="Nicolas_S_feature" /locus_tag="new_671929_671993" /HighExp="Salt, S0, aero, T-0.40H, T-1.40H, SMMPr, T-1.10H, T0.0H, Cold, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S221" CDS 596219..597244 /gene="ydjG" /locus_tag="BSU_06190" /old_locus_tag="BSU06190" /function="16.5: Explore" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage replication protein; prophage region 3" /protein_id="NP_388500.1" /db_xref="EnsemblGenomes-Gn:BSU06190" /db_xref="EnsemblGenomes-Tr:CAB12438" /db_xref="GOA:O34434" /db_xref="InterPro:IPR013137" /db_xref="SubtiList:BG12798" /db_xref="UniProtKB/Swiss-Prot:O34434" /translation="MIISYKCPNCGSDMAFDSETGSLSCSSCGRQDNIESLPKENIAA RFSDDEAKEYQCKNCGAVLITEAETTATTCSFCGGAAILADRLSGHLAPAKVIPFTIS KQEAEQAFRKWCKKGLLTPRGFMSADRIKSITGMYIPFWMFDLNSEVQVRANCTRVHQ YEEGDYICTETEHFEAFRDINLDYLKIPVDASEKMKDELMDKLEPYSYEELKDFQTAY LAGYIAEKYNYTDEELFPRAKEKISSYIDSYIHSTFSGYTSVNVRDKHIHTKNVNSFY VLLPVWMVSYDYERAEHIFAMNGQTGKVVGKPPISRGKVAAWFSGIAGGTFLALKLVS LMMGGGF*" /label="ydjG CDS" gene 596219..597244 /gene="ydjG" /locus_tag="BSU_06190" /old_locus_tag="BSU06190" /label="ydjG gene" CDS 597244..598008 /gene="ydjH" /locus_tag="BSU_06200" /old_locus_tag="BSU06200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; prophage region 3" /protein_id="NP_388501.1" /db_xref="EnsemblGenomes-Gn:BSU06200" /db_xref="EnsemblGenomes-Tr:CAB12439" /db_xref="GOA:O35004" /db_xref="InterPro:IPR007621" /db_xref="SubtiList:BG12799" /db_xref="UniProtKB/Swiss-Prot:O35004" /translation="MRGFFGKAIFVVLAVFIMMPLLGIEAVRASELQQHVYDRAHLLS KAEIGKLESLSAKLGAKRDTDFIIITTKSTNGEDIADYTGDFYDRYGKGSTAILTIDM TNREVFIAGFKKAEQYLDNSRLNSIRNTISSDLSNENYFEAFETYIQLSYKDMGIKPG VNPDNIFFTWWFQLIAAIAVGGIAVSIMLYHAGGKVTVNGSTYMDQRTSDVIDQYDTY IRTTVTRERKPSDKDSGSDGGVTKGGTSYSGSRGSF*" /label="ydjH CDS" gene 597244..598008 /gene="ydjH" /locus_tag="BSU_06200" /old_locus_tag="BSU06200" /label="ydjH gene" CDS 598039..599010 /gene="ydjI" /locus_tag="BSU_06210" /old_locus_tag="BSU06210" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="NP_388502.1" /db_xref="EnsemblGenomes-Gn:BSU06210" /db_xref="EnsemblGenomes-Tr:CAB12440" /db_xref="InterPro:IPR033880" /db_xref="InterPro:IPR036013" /db_xref="SubtiList:BG12800" /db_xref="UniProtKB/Swiss-Prot:O34789" /translation="MSFFRNQLANVVEWEEFRDDMIFYKWNNREIKKGSRLIIRPGQD AVFLNNGRVEGVFQDDGDYDIESEIIPFLSTLKGFKFGFNSGMRAEVLFVNTKEFTVR WGTKQAINIPAAGMPGGMPIRANGTFNFKVQDYISLIDKIAGVKDQYFVEDIKTRIIS ILDQLLMKWITREGKDMFNLQANAFDIAKGIQEDLDMQLISDGMTVTGFQIMSFNYPQ EVQDMITKNASYGMVGDVNRYQQISMTDGMASGKMSGSGAASDMAGMMMGMNMANQMM NQMNQNQQAQSSGPQSTGSGSKPNFCPNCGTKTGEANFCPNCGQKLV*" /label="ydjI CDS" gene 598039..599010 /gene="ydjI" /locus_tag="BSU_06210" /old_locus_tag="BSU06210" /label="ydjI gene" downshifts 599000 /Source="Nicolas_upshifts" /id="D300" /incds=0 /nref=180 /ntot=247 /MaxReadThrough="2.71622" /MaxDrop="5.81579" /score="16.72046" /energy="-11.1" /TU="U477" /idTUdmin="U477" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 599044 /Source="Nicolas_upshifts" /id="D301" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="2.13813" /MaxDrop="3.25329" /score="16.72046" /energy="-11.1" /TU="NA" /idTUdmin="U477" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(599057..600082) /gene="ydjJ" /locus_tag="BSU_06220" /old_locus_tag="BSU06220" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane associated potassium channel; prophage region 3" /protein_id="NP_388503.1" /db_xref="EnsemblGenomes-Gn:BSU06220" /db_xref="EnsemblGenomes-Tr:CAB12441" /db_xref="GOA:O34733" /db_xref="InterPro:IPR013099" /db_xref="SubtiList:BG12801" /db_xref="UniProtKB/Swiss-Prot:O34733" /translation="MNEGYIIAGLLLLTAGMIDFLWTTLWLESGAGPITRCLSAWLWK GCRKISGDHAKVLSMAGPLLLCLTLVIWISLFWSGWVLIYSSDPHSLMETQSKEPASW SDRIYFSGYVMFTLGNGDLAPNGGLWKLVTIIETAQGLLTITFSVTYLISVLSAVNQK RSFAQSVLSLGHDGTEIVHNAWNGKDFHDIDFLLVAASSELGKLTAQHNAFPILHFYH STQHQESSIIAVAVLDEALTIFKYGIPEQYQPNQLHIKEARSSIKNYLDTVHTAYIHP AEQAPPEPDISKLQQSGIPALSKQTFQIAVNSIKERRQLLLGIIQAGARKWPVQEQAI GNAYSPK*" /label="ydjJ CDS" gene complement(599057..600082) /gene="ydjJ" /locus_tag="BSU_06220" /old_locus_tag="BSU06220" /label="ydjJ gene" promotor_-10 complement(600114..600133) /Source="Nicolas_upshift_promotors" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(600132) /Source="Nicolas_upshifts" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(600147..600153) /Source="Nicolas_upshift_promotors" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 600342..600349 /Source="Nicolas_upshift_promotors" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 600362 /Source="Nicolas_upshifts" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="upshifts" S_feature 600364..600666 /Source="Nicolas_S_feature" /locus_tag="new_676139_676441" /HighExp="M0t90, M40t90, Lbtran, T0.30H, BI, T1.0H, M9-stat, S1, T1.30H, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.28450700000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S222" promotor_-10 600364..600383 /Source="Nicolas_upshift_promotors" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 600667..602088 /gene="iolT" /locus_tag="BSU_06230" /old_locus_tag="BSU06230" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11807058, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11807058, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="myo-inositol transporter" /protein_id="NP_388504.1" /db_xref="EnsemblGenomes-Gn:BSU06230" /db_xref="EnsemblGenomes-Tr:CAB12442" /db_xref="GOA:O34718" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12802" /db_xref="UniProtKB/Swiss-Prot:O34718" /translation="MNKQGNQMSFLRTIILVSTFGGLLFGYDTGVLNGALPYMGEPDQ LNLNAFTEGLVTSSLLFGAALGAVFGGRMSDFNGRRKNILFLAVIFFISTIGCTFAPN VTVMIISRFVLGIAVGGASVTVPAYLAEMSPVESRGRMVTQNELMIVSGQLLAFVFNA ILGTTMGDNSHVWRFMLVIASLPALFLFFGMIRMPESPRWLVSKGRKEDALRVLKKIR DEKRAAAELQEIEFAFKKEDQLEKATFKDLSVPWVRRIVFIGLGIAIVQQITGVNSIM YYGTEILRNSGFQTEAALIGNIANGVISVLATFVGIWLLGRVGRRPMLMTGLIGTTTA LLLIGIFSLVLEGSPALPYVVLSLTVTFLAFQQGAISPVTWLMLSEIFPLRLRGLGMG VTVFCLWMVNFAVSFTFPILLAAIGLSTTFFIFVGLGICSVLFVKRFLPETKGLSLEQ LEENFRAYDHSGAKKDSGAEVIG*" /label="iolT CDS" gene 600667..602088 /gene="iolT" /locus_tag="BSU_06230" /old_locus_tag="BSU06230" /label="iolT gene" downshifts 602080 /Source="Nicolas_upshifts" /id="D302" /incds=0 /nref=11 /ntot=24 /MaxReadThrough="2.82455" /MaxDrop="8.02371" /score="11.3880907" /energy="-11.2" /TU="NA" /idTUdmin="U479" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(602136) /Source="Nicolas_upshifts" /id="D303" /incds=0 /nref=242 /ntot=272 /MaxReadThrough="1.00274" /MaxDrop="9.32541" /score="13.6781112" /energy="-11.2" /TU="NA" /idTUdmin="U482" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(602136..603176) /gene="bdhA" /locus_tag="BSU_06240" /old_locus_tag="BSU06240" /EC_number="1.1.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12469342, 18820069, 24525333, 26428232, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12469342, 18820069, 24525333, 26428232, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin reductase/2,3-butanediol dehydrogenase" /protein_id="NP_388505.1" /db_xref="EnsemblGenomes-Gn:BSU06240" /db_xref="EnsemblGenomes-Tr:CAB12443" /db_xref="GOA:O34788" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12803" /db_xref="UniProtKB/Swiss-Prot:O34788" /translation="MKAARWHNQKDIRIEHIEEPKTEPGKVKIKVKWCGICGSDLHEY LGGPIFIPVDKPHPLTNETAPVTMGHEFSGEVVEVGEGVENYKVGDRVVVEPIFATHG HQGAYNLDEQMGFLGLAGGGGGFSEYVSVDEELLFKLPDELSYEQGALVEPSAVALYA VRSSKLKAGDKAAVFGCGPIGLLVIEALKAAGATDIYAVELSPERQQKAEELGAIIVD PSKTDDVVAEIAERTGGGVDVAFEVTGVPVVLRQAIQSTTIAGETVIVSIWEKGAEIH PNDIVIKERTVKGIIGYRDIFPAVLSLMKEGYFSADKLVTKKIVLDDLIEEGFGALIK EKSQVKILVRPN*" /label="bdhA CDS" gene complement(602136..603176) /gene="bdhA" /locus_tag="BSU_06240" /old_locus_tag="BSU06240" /label="bdhA gene" promotor_-35 602716..602725 /Source="Nicolas_upshift_promotors" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 602739..602758 /Source="Nicolas_upshift_promotors" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 602740..603275 /Source="Nicolas_S_feature" /locus_tag="new_678515_679050" /HighExp="C30, Gly, S6, C90, S8, BT, S7, Sw, Fru, Lbstat" /AntisenseName="bdhA" /AntisenseCor="-0.174163895138467" /AntisenseRegPval="-2.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S223" upshifts 602740 /Source="Nicolas_upshifts" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(603177..603471) /Source="Nicolas_S_feature" /locus_tag="new_678952_679246_c" /HighExp="Lbtran, BI, T1.0H, M40t90, LBGstat, LoTm, T0.30H, LPhT, Lbstat, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S224" misc_feature 603276..603295 /Source="Nicolas_upshift_promotors" /id="U481" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.994005994005994" /xcortree=1752 /SigmaFactorBS="accggtcaatatgaactgttcacaaaatcgccatttttaaaa ccaaaaaagaaatgaaaTTTTTATATAATATAATCTAcgtttttttgaaaaaaagaaa c" /listShort="S225" /listLong="ydjM, ydjN" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 603277..603574 /Source="Nicolas_S_feature" /locus_tag="new_679052_679349" /HighExp="G180, Paraq, Oxctl, H2O2, G135, G150, MG 5, C30, UNK1, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S225" upshifts 603277 /Source="Nicolas_upshifts" /id="U481" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.994005994005994" /xcortree=1752 /SigmaFactorBS="accggtcaatatgaactgttcacaaaatcgccatttttaaaa ccaaaaaagaaatgaaaTTTTTATATAATATAATCTAcgtttttttgaaaaaaagaaa c" /listShort="S225" /listLong="ydjM, ydjN" /label="upshifts" misc_feature complement(603466..603480) /Source="Nicolas_upshift_promotors" /id="U482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig="0.99000999000999" /xcortree=3201 /SigmaFactorBS="tacaaagtcaaaaaagttacctctgctaaaataaaccatgga agattatccTATTATAATAGCAGTattagagttataattattgatagagtagttgtcg c" /listShort="S224, bdhA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(603471) /Source="Nicolas_upshifts" /id="U482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig="0.99000999000999" /xcortree=3201 /SigmaFactorBS="tacaaagtcaaaaaagttacctctgctaaaataaaccatgga agattatccTATTATAATAGCAGTattagagttataattattgatagagtagttgtcg c" /listShort="S224, bdhA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 603573..603592 /Source="Nicolas_upshift_promotors" /id="U483" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.998001998001998" /xcortree=3034 /SigmaFactorBS="cttttttgactttgtaacattactgtaaggatattgaaAtaa aaaatagctggttgaTCGTGTATAATCTTCCTAGAtgttaacaaacagggggacgaaa t" /listShort="ydjM, ydjN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 603576 /Source="Nicolas_upshifts" /id="U483" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.998001998001998" /xcortree=3034 /SigmaFactorBS="cttttttgactttgtaacattactgtaaggatattgaaAtaa aaaatagctggttgaTCGTGTATAATCTTCCTAGAtgttaacaaacagggggacgaaa t" /listShort="ydjM, ydjN" /GFF_Attribute="listLong" /label="upshifts" CDS 603615..603986 /gene="walM" /locus_tag="BSU_06250" /old_locus_tag="BSU06250" /experiment="publication(s) with functional evidences, PMID:17581128, 20487291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17581128, 20487291; Product type f: factor" /codon_start=1 /transl_table=11 /product="protein involved in cell wall metabolism" /protein_id="NP_388506.1" /db_xref="EnsemblGenomes-Gn:BSU06250" /db_xref="EnsemblGenomes-Tr:CAB12444" /db_xref="InterPro:IPR009009" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG11036" /db_xref="UniProtKB/Swiss-Prot:P40775" /translation="MLKKVILAAFILVGSTLGAFSFSSDASAKHVNGNITWYNGVGKK GSSGKKLGHWDCATKIGFDVPRNGTKIRAYAKAKPKKVITVYKNDVGRMPNAVLDVSP KAFKALGYPLSKGKVAGHYSY*" /label="walM CDS" gene 603615..603986 /gene="walM" /locus_tag="BSU_06250" /old_locus_tag="BSU06250" /label="walM gene" downshifts 603972 /Source="Nicolas_upshifts" /id="D304" /incds=0 /nref=5 /ntot=52 /MaxReadThrough="5.74148" /MaxDrop="2.8439" /score="-1.55787542" /energy="-7.4" /TU="U483" /idTUdmin="U481" /TUdmin=418 /isTUend="FALSE" /label="downshifts" CDS 604052..605098 /gene="ydjN" /locus_tag="BSU_06260" /old_locus_tag="BSU06260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388507.1" /db_xref="EnsemblGenomes-Gn:BSU06260" /db_xref="EnsemblGenomes-Tr:CAB12445" /db_xref="InterPro:IPR011659" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12804" /db_xref="UniProtKB/Swiss-Prot:O34353" /translation="MKKRIILLLAVIIAAAAAGVAFYVAKDKGHEKAADVSVNTESGD ELLVSITDTDLLTKYYENDKVIHEEKLTSYPAFALDQKQQVLYYTGNNEQNEMRLFKL DLKSHKKTMLYKGAESADSLFLSKDRSTIYFRLGKADESNFRIAAFDLKTKKYKNLYP AANDQDDTVSSFFYNQKNDSFALLHYSVEEDYKKTDEANEKGIDPEPTTIHFAEGRQN KFNELKSLNQFISDIAVSDDDKRILFTSYTQKGTEQTASIQMLNADTKKYESIISNQK SFKLLIDAQPQFSKDGKNIYFLAEAKGAKKLKDETGREAKVRTIYSYSLENKTFKKVW ENPNGIINSFFVIN*" /label="ydjN CDS" gene 604052..605098 /gene="ydjN" /locus_tag="BSU_06260" /old_locus_tag="BSU06260" /label="ydjN gene" downshifts 605072 /Source="Nicolas_upshifts" /id="D305" /incds=0 /nref=41 /ntot=177 /MaxReadThrough="1.73572" /MaxDrop="4.49184" /score="21.8200083" /energy="-13.9" /TU="NA" /idTUdmin="U483" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(605132..605290) /gene="ydzJ" /locus_tag="BSU_06269" /old_locus_tag="BSU06269" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097689.1" /db_xref="EnsemblGenomes-Gn:BSU06269" /db_xref="EnsemblGenomes-Tr:CAX52576" /db_xref="GOA:O24817" /db_xref="UniProtKB/Swiss-Prot:O24817" /translation="MISNQQQKDLKKRAAFKKLNVAMNSYVELLFLSVPLIHIFKWLG SLALHLIH*" /label="ydzJ CDS" gene complement(605132..605290) /gene="ydzJ" /locus_tag="BSU_06269" /old_locus_tag="BSU06269" /label="ydzJ gene" downshifts complement(605148) /Source="Nicolas_upshifts" /id="D306" /incds=0 /nref=23 /ntot=155 /MaxReadThrough="0.7906" /MaxDrop="3.61386" /score="9.10659473" /energy="-10.1" /TU="NA" /idTUdmin="U487" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(605347..605479) /Source="Nicolas_S_feature" /locus_tag="new_681122_681254_c" /HighExp="LoTm, S8, S5, S6, S4, B36, S7, Cold, B60, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigWXY" /TUshortPSig="0.994, 1, 1" /TUlongSig="SigK" /TUlongPSig="0.994" /label="S226" downshifts complement(605390) /Source="Nicolas_upshifts" /id="D307" /incds=0 /nref=57 /ntot=272 /MaxReadThrough="3.03092" /MaxDrop="6.46708" /score="5.41743429" /energy="-8.4" /TU="U484,U486,U487" /idTUdmin="U484" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(605480..605689) /gene="ydjO" /locus_tag="BSU_06270" /old_locus_tag="BSU06270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28197687" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388508.1" /db_xref="EnsemblGenomes-Gn:BSU06270" /db_xref="EnsemblGenomes-Tr:CAB12446" /db_xref="InterPro:IPR025916" /db_xref="SubtiList:BG12805" /db_xref="UniProtKB/Swiss-Prot:O34759" /translation="MSYYNKRNQEPLPKEDVSTWECTKEDCNGWTRKNFASSDTPLCP LCGSKMVDGIRSLVNLQNNSQTKTS*" /label="ydjO CDS" gene complement(605480..605689) /gene="ydjO" /locus_tag="BSU_06270" /old_locus_tag="BSU06270" /label="ydjO gene" promotor_-10 complement(605722..605741) /Source="Nicolas_upshift_promotors" /id="U484" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.66033966033966" /psig="0.994005994005994" /xcortree=586 /SigmaFactorBS="tggggttattggaaagtcataaagaaaaaggaattAggagat tagggaaaagTATGAGACAATAGGAAATGTgcagtaaaatacatgagggaagaagtga c" /listShort="ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(605733) /Source="Nicolas_upshifts" /id="U484" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.66033966033966" /psig="0.994005994005994" /xcortree=586 /SigmaFactorBS="tggggttattggaaagtcataaagaaaaaggaattAggagat tagggaaaagTATGAGACAATAGGAAATGTgcagtaaaatacatgagggaagaagtga c" /listShort="ydjO, S226" /GFF_Attribute="listLong" /label="upshifts" CDS complement(605772..606587) /gene="ydjP" /locus_tag="BSU_06280" /old_locus_tag="BSU06280" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9987136; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminoacrylate hydrolase" /protein_id="NP_388509.1" /db_xref="EnsemblGenomes-Gn:BSU06280" /db_xref="EnsemblGenomes-Tr:CAB12447" /db_xref="GOA:O34592" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12806" /db_xref="UniProtKB/Swiss-Prot:O34592" /translation="MPYIILEDQTRLYYETHGSGTPILFIHGVLMSGQFFHKQFSVLS ANYQCIRLDLRGHGESDKVLHGHTISQYARDIREFLNAMELDHVVLAGWSMGAFVVWD YLNQFGNDNIQAAVIIDQSASDYQWEGWEHGPFDFDGLKTAMHAIQTDPLPFYESFIQ NMFAEPPAETETEWMLAEILKQPAAISSTILFNQTAADYRGTLQNINVPALLCFGEDK KFFSTAAGEHLRSNIPNATLVTFPKSSHCPFLEEPDAFNSTLLSFLDGVIGKS*" /label="ydjP CDS" gene complement(605772..606587) /gene="ydjP" /locus_tag="BSU_06280" /old_locus_tag="BSU06280" /label="ydjP gene" promotor_-35 606414..606423 /Source="Nicolas_upshift_promotors" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 606436..606455 /Source="Nicolas_upshift_promotors" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 606436 /Source="Nicolas_upshifts" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(606600..607589) /gene="yeaA" /locus_tag="BSU_06290" /old_locus_tag="BSU06290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388510.1" /db_xref="EnsemblGenomes-Gn:BSU06290" /db_xref="EnsemblGenomes-Tr:CAB12448" /db_xref="InterPro:IPR025062" /db_xref="SubtiList:BG12210" /db_xref="UniProtKB/Swiss-Prot:O34803" /translation="MLTHDLHEKTKHYISIYAELKTKLKWKVSHDQILMLISSAYIVN KREFDFQRFYDLSSYIKSNIGSFSTLNSHHRFTVASILDIHFQHEAKQTFQTFIDVYN EMVKLGYKRDMFTYLSALILLTGKSETTNQKEQMNMGLAVYQQMKKNHYFLTSTQNVP LAVLLGENGKGLQALQKAETCYQLLAANGFKKGQYLHQVSHILALQSEKEPEMLVSAC KQIYQSITESVKKTKDYHYPDLALLTFLEEPDIKTVLCITDELNQEKAFKWQKEMNFK IAVSLYLSEHMEKNLLMESGLYTAIETVIQAQQAAATAAIISSTAASHTHDGN*" /label="yeaA CDS" gene complement(606600..607589) /gene="yeaA" /locus_tag="BSU_06290" /old_locus_tag="BSU06290" /label="yeaA gene" promotor_-10 complement(607454..607472) /Source="Nicolas_upshift_promotors" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(607462) /Source="Nicolas_upshifts" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(607488..607493) /Source="Nicolas_upshift_promotors" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(607611..607626) /Source="Nicolas_upshift_promotors" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(607632) /Source="Nicolas_upshifts" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(607638..607647) /Source="Nicolas_upshift_promotors" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(607687..609228) /gene="cotA" /locus_tag="BSU_06300" /old_locus_tag="BSU06300" /EC_number="1.3.3.5" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11514528, 12637519, 16391148, 17242517, 18031270, 19933362, 22112278, 25259857, 27050268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11514528, 12637519, 16391148, 17242517, 18031270, 19933362, 22112278, 25259857, 27050268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="outer spore coat copper-dependent promiscuous laccase" /protein_id="NP_388511.1" /db_xref="EnsemblGenomes-Gn:BSU06300" /db_xref="EnsemblGenomes-Tr:CAB12449" /db_xref="GOA:P07788" /db_xref="InterPro:IPR001117" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR011706" /db_xref="InterPro:IPR011707" /db_xref="PDB:1GSK" /db_xref="PDB:1OF0" /db_xref="PDB:1W6L" /db_xref="PDB:1W6W" /db_xref="PDB:1W8E" /db_xref="PDB:2BHF" /db_xref="PDB:2WSD" /db_xref="PDB:2X87" /db_xref="PDB:2X88" /db_xref="PDB:3ZDW" /db_xref="PDB:4A66" /db_xref="PDB:4A67" /db_xref="PDB:4A68" /db_xref="PDB:4AKO" /db_xref="PDB:4AKP" /db_xref="PDB:4AKQ" /db_xref="PDB:4Q89" /db_xref="PDB:4Q8B" /db_xref="PDB:4YVN" /db_xref="PDB:4YVU" /db_xref="SubtiList:BG10490" /db_xref="UniProtKB/Swiss-Prot:P07788" /translation="MTLEKFVDALPIPDTLKPVQQSKEKTYYEVTMEECTHQLHRDLP PTRLWGYNGLFPGPTIEVKRNENVYVKWMNNLPSTHFLPIDHTIHHSDSQHEEPEVKT VVHLHGGVTPDDSDGYPEAWFSKDFEQTGPYFKREVYHYPNQQRGAILWYHDHAMALT RLNVYAGLVGAYIIHDPKEKRLKLPSDEYDVPLLITDRTINEDGSLFYPSAPENPSPS LPNPSIVPAFCGETILVNGKVWPYLEVEPRKYRFRVINASNTRTYNLSLDNGGDFIQI GSDGGLLPRSVKLNSFSLAPAERYDIIIDFTAYEGESIILANSAGCGGDVNPETDANI MQFRVTKPLAQKDESRKPKYLASYPSVQHERIQNIRTLKLAGTQDEYGRPVLLLNNKR WHDPVTETPKVGTTEIWSIINPTRGTHPIHLHLVSFRVLDRRPFDIARYQESGELSYT GPAVPPPPSEKGWKDTIQAHAGEVLRIAATFGPYSGRYVWHCHILEHEDYDMMRPMDI TDPHK*" /label="cotA CDS" gene complement(607687..609228) /gene="cotA" /locus_tag="BSU_06300" /old_locus_tag="BSU06300" /label="cotA gene" downshifts complement(607700) /Source="Nicolas_upshifts" /id="D308" /incds=0 /nref=46 /ntot=93 /MaxReadThrough="2.97674" /MaxDrop="5.60726" /score="22.3755425" /energy="-9.1" /TU="U488" /idTUdmin="U488" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(609259..609278) /Source="Nicolas_upshift_promotors" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="promotor_-10" upshifts complement(609273) /Source="Nicolas_upshifts" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="upshifts" promotor_-35 complement(609292..609301) /Source="Nicolas_upshift_promotors" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="promotor_-35" CDS complement(609380..610789) /gene="gabP" /locus_tag="BSU_06310" /old_locus_tag="BSU06310" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15849754, 16547045, 16850406, 8951816, 9677314, 24142252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16547045, 16850406, 8951816, 9677314, 24142252; Product type t : transporter" /codon_start=1 /transl_table=11 /product="gamma-aminobutyrate (GABA) permease; proline permease" /protein_id="NP_388512.2" /db_xref="EnsemblGenomes-Gn:BSU06310" /db_xref="EnsemblGenomes-Tr:CAB12450" /db_xref="GOA:P46349" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="InterPro:IPR011265" /db_xref="SubtiList:BG11328" /db_xref="UniProtKB/Swiss-Prot:P46349" /translation="MNQSQSGLKKELKTRHMTMISIAGVIGAGLFVGSGSVIHSTGPG AVVSYALAGLLVIFIMRMLGEMSAVNPTSGSFSQYAHDAIGPWAGFTIGWLYWFFWVI VIAIEAIAGAGIIQYWFHDIPLWLTSLILTIVLTLTNVYSVKSFGEFEYWFSLIKVVT IIAFLIVGFAFIFGFAPGSEPVGFSNLTGKGGFFPEGISSVLLGIVVVIFSFMGTEIV AIAAGETSNPIESVTKATRSVVWRIIVFYVGSIAIVVALLPWNSANILESPFVAVLEH IGVPAAAQIMNFIVLTAVLSCLNSGLYTTSRMLYSLAERNEAPRRFMKLSKKGVPVQA IVAGTFFSYIAVVMNYFSPDTVFLFLVNSSGAIALLVYLVIAVSQLKMRKKLEKTNPE ALKIKMWLFPFLTYLTIIAICGILVSMAFIDSMRDELLLTGVITGIVLISYLVFRKRK VSEKAAANPVTQQQPDILP*" /label="gabP CDS" gene complement(609380..610789) /gene="gabP" /locus_tag="BSU_06310" /old_locus_tag="BSU06310" /label="gabP gene" downshifts complement(609394) /Source="Nicolas_upshifts" /id="D309" /incds=0 /nref=124 /ntot=216 /MaxReadThrough="3.22899" /MaxDrop="5.0359" /score="18.985683" /energy="-13.5" /TU="U489" /idTUdmin="U489" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" CDS complement(610827..611114) /gene="ydzX" /locus_tag="BSU_06319" /old_locus_tag="BSU06319" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097690.1" /db_xref="EnsemblGenomes-Gn:BSU06319" /db_xref="EnsemblGenomes-Tr:CAX52577" /db_xref="UniProtKB/Swiss-Prot:C0H3X2" /translation="MIHPPQKNSDEGTLFLSSNLFAPPKIPSNPRTPVLLAFYRIVNI TQNHTANKKRNIFSTHSLKAQTKHYKFEISWYIFLHEFSTNCIFMIEFQLS*" /label="ydzX CDS" gene complement(610827..611114) /gene="ydzX" /locus_tag="BSU_06319" /old_locus_tag="BSU06319" /label="ydzX gene" misc_feature complement(610830..610849) /Source="Nicolas_upshift_promotors" /id="U489" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2898 /SigmaFactorBS="tttgaaataagctggtatattttcttacacgaattttcgaca aactgtatatttaTGATAGAGTTTCAATTATCAtaatattcagtaatgattgcatttt a" /listShort="gabP" /listLong="cotA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(610844) /Source="Nicolas_upshifts" /id="U489" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2898 /SigmaFactorBS="tttgaaataagctggtatattttcttacacgaattttcgaca aactgtatatttaTGATAGAGTTTCAATTATCAtaatattcagtaatgattgcatttt a" /listShort="gabP" /listLong="cotA" /label="upshifts" promotor_-35 611120..611127 /Source="Nicolas_upshift_promotors" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 611143..611162 /Source="Nicolas_upshift_promotors" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 611144 /Source="Nicolas_upshifts" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="upshifts" CDS 611187..612059 /gene="mneS" /locus_tag="BSU_06320" /old_locus_tag="BSU06320" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="secondary Mn(II) exporter, promiscuous" /protein_id="NP_388513.1" /db_xref="EnsemblGenomes-Gn:BSU06320" /db_xref="EnsemblGenomes-Tr:CAB12451" /db_xref="GOA:P46348" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG11329" /db_xref="UniProtKB/Swiss-Prot:P46348" /translation="MERYDELKKGESGALVSIAAYLVLSAIKLIIGYLFHSEALTADG LNNTTDIIASVAVLIGLRISQKPPDEDHPYGHFRAETIASLIASFIMMVVGLQVLFSA GESIFSAKQETPDMIAAWTAAGGAVLMLIVYRYNKRLAKKVKSQALLAAAADNKSDAF VSIGTFIGIVAAQFHLAWIDTVTAFVIGLLICKTAWDIFKESSHSLTDGFDIKDISAY KQTIEKISGVSRLKDIKARYLGSTVHVDVVVEVSADLNITESHDIANEIERRMKEEHA IDYSHVHMEPLEQK*" /label="mneS CDS" gene 611187..612059 /gene="mneS" /locus_tag="BSU_06320" /old_locus_tag="BSU06320" /label="mneS gene" downshifts 612024 /Source="Nicolas_upshifts" /id="D310" /incds=0 /nref=2 /ntot=88 /MaxReadThrough="1.72291" /MaxDrop="2.86431" /score="24.8167732" /energy="-10.2" /TU="U490" /idTUdmin="U490" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts complement(612299) /Source="Nicolas_upshifts" /id="D311" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="0.65827" /MaxDrop="3.33542" /score="-0.424989042" /energy="-12.9" /TU="NA" /idTUdmin="U489" /TUdmin="-3015" /isTUend="FALSE" /label="downshifts" misc_feature 612353..612372 /Source="Nicolas_upshift_promotors" /id="U491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2248 /SigmaFactorBS="ctttattggtaacaatttgctagaatcgtttttttatacaga ttgcttttTGTGGTAAAGTTAGGTTACAttatgatgaattttgtagatgactaggagg a" /listShort="yeaC, yeaD, yebA" /listLong="S227, guaA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 612363 /Source="Nicolas_upshifts" /id="U491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2248 /SigmaFactorBS="ctttattggtaacaatttgctagaatcgtttttttatacaga ttgcttttTGTGGTAAAGTTAGGTTACAttatgatgaattttgtagatgactaggagg a" /listShort="yeaC, yeaD, yebA" /listLong="S227, guaA" /label="upshifts" CDS 612409..613371 /gene="yeaC" /locus_tag="BSU_06330" /old_locus_tag="BSU06330" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21907250, 26933057; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative MoxR-like ATPase" /protein_id="NP_388514.2" /db_xref="EnsemblGenomes-Gn:BSU06330" /db_xref="EnsemblGenomes-Tr:CAB12452" /db_xref="GOA:P94474" /db_xref="InterPro:IPR011703" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12211" /db_xref="UniProtKB/Swiss-Prot:P94474" /translation="MAYQEDLHPLLGKAVEHINRVMVGKRDIAILSLAALLAKGHVLL EDVPGVGKTMMVRALAKSIGADFKRIQFTPDLLPSDVTGVSIYNAKTMEFEYRPGPIM GNIVLADEINRTSPKTQSALLEAMEEGSVTVDGHTMQLADPFFVMATQNPVEYEGTYP LPEAQLDRFLFKLRMGYPSFNEELDVLSLQEKSHPIETLEPVIAKEDFIFLQREVQNV RADDSIKEYIVEIVQKTRQHPSVQLGVSPRGSIALMKAAQAYALLHHRDYVIPDDIQY LAPFTLPHRMMLHPEAKFEGIQAEAIVREIMSAVKVPVQRSAVR*" /label="yeaC CDS" gene 612409..613371 /gene="yeaC" /locus_tag="BSU_06330" /old_locus_tag="BSU06330" /label="yeaC gene" CDS 613371..614567 /gene="yeaD" /locus_tag="BSU_06340" /old_locus_tag="BSU06340" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388515.2" /db_xref="EnsemblGenomes-Gn:BSU06340" /db_xref="EnsemblGenomes-Tr:CAB12453" /db_xref="InterPro:IPR002881" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12212" /db_xref="UniProtKB/Swiss-Prot:P94475" /translation="MNKKWQWLVYGWKLIILTLLTAAVFSYAMFQGGFVSWFLFYAFL PFVLYAGLLALYPLRSFQASRQMDKTQLHAGDRLGVTVTLRRKLPFPLMYMVIEDCLP EGIESLNRDGAAAKRLVFPWFKRSMTMSYELARVPRGEHHFHSVRVRTGDVLGLIEKT AFFELDDTLFVYPFYQRFSYQVNERHQEDGVSGSSPIHQHHSSVAASVRNYQPGDRFA ALDWKTSARRSQLMTKEFEPSRSKNLFLLMDRFSSDAFEEVVSVTASILHSVLKNGAG AGLASIGKEKNIFPIQEGDQHFKHMLRHLAIAHCDAADPISRYAREELGKPSVRQADQ VVVTGQLTEDMLHLAEIGGGRVTVILAKEKDAELSQAENVMIERMMKRQIRVRIMRGG RVSRVV*" /label="yeaD CDS" gene 613371..614567 /gene="yeaD" /locus_tag="BSU_06340" /old_locus_tag="BSU06340" /label="yeaD gene" CDS 614589..616802 /gene="yebA" /locus_tag="BSU_06350" /old_locus_tag="BSU06350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388516.2" /db_xref="EnsemblGenomes-Gn:BSU06350" /db_xref="EnsemblGenomes-Tr:CAB12454" /db_xref="GOA:P94476" /db_xref="InterPro:IPR002931" /db_xref="InterPro:IPR025403" /db_xref="InterPro:IPR036985" /db_xref="SubtiList:BG12213" /db_xref="UniProtKB/Swiss-Prot:P94476" /translation="MPHDDHKGSRLSLLLFYFLAFLLLWEWLRPLDSFTETKHTGFFS VFIGLTFLLTFFRMRWFVTVPFCVIFTLISIHILFYQGSIFDLSWVSSFLQDVYLNIT LIQSGQWNDMIPSFRTLLFFVLLWLLVYLLHYWVIYQRRILFFFLMTVAYITILDTFT PYDATFAVIRIVLIGFFMLGLLYLERIKLMERITLPKTSVLKWFLPLSVLVLAATGFG LAAPKSEPAWPDPVPFLKKITHQDRVSAGESKIGYGNHDESLGGPFQQDATPVFTWQG KERTYFRVETKDTYTGKGWIETDTGMSYQLSNGKVENLWFDHKVATERRTVRVKVDKH YGYNHLMYPIGAETIQPKQAVSLEMNGNTEQISPISEQAGEIRNMGNYTVTYNSPVYK LDELRKVKVRKNSEEYTFSDRYMQLPDSLPERVRTLAIKLTQDHDNMFDKVKAVEDYL GSNAFTYETENVTIPKNDEDYVDQFLFETKMGYCDNFSSAMVVLLRSAGIPARWVKGY TSGEYKEAGNKNGSIYEVTNNNAHSWVEVYFPEQGWVTFEPTKGFTNPAQFTSSDTKD SGSDSSSSPKKAKEKQKEEKKQPQKEEKQKEKREPAVSKKPSASHTNAGAGLYAALAV LAVLLVAAVLLYVFRSLWIPVFAVRKLKRRSDQHAFFEAYGALLKQLKRKGLPKRDSE TLRDYAKRIDEKYDIEDMSKLTLSYERALYRNEDSSALWNDSRELWENLIKRRWS*" /label="yebA CDS" gene 614589..616802 /gene="yebA" /locus_tag="BSU_06350" /old_locus_tag="BSU06350" /label="yebA gene" promotor_-35 616797..616804 /Source="Nicolas_upshift_promotors" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 616819..616838 /Source="Nicolas_upshift_promotors" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 616835..616964 /Source="Nicolas_S_feature" /locus_tag="new_692610_692739" /HighExp="G180, Oxctl, G135, LBGexp, G150, Paraq, C30, LPh, MG 25, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.63292099999999996" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S227" upshifts 616835 /Source="Nicolas_upshifts" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="upshifts" CDS 616965..618506 /gene="guaA" /locus_tag="BSU_06360" /old_locus_tag="BSU06360" /EC_number="6.3.5.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1312531, 21856856; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GMP synthetase" /protein_id="NP_388517.2" /db_xref="EnsemblGenomes-Gn:BSU06360" /db_xref="EnsemblGenomes-Tr:CAB12455" /db_xref="GOA:P29727" /db_xref="InterPro:IPR001674" /db_xref="InterPro:IPR004739" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR022310" /db_xref="InterPro:IPR022955" /db_xref="InterPro:IPR025777" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10647" /db_xref="UniProtKB/Swiss-Prot:P29727" /translation="MTKLVNEMILVLDFGSQYNQLITRRIREFGVYSELHPHTLTAEE IKKMNPKGIILSGGPNSVYDENSFRCDEKIFELDIPVLGICYGMQLMTHYLGGKVEAA SQREYGKANIRIEGTPDLFRDLPNEQVVWMSHGDLVVEVPEGFTVDATSHHCPNSAMS KADKKWYGVQFHPEVRHSEYGNDLLKNFVFGVCECEGEWSMENFIEIEMQKIRETVGD KQVLCALSGGVDSSVVAVLIHKAIGDQLTCIFVDHGLLRKGEAEGVMKTFSEGFNMNV IKVDAKDRFLNKLKGVSDPEQKRKIIGNEFIYVFDDEADKLKGIDYLAQGTLYTDIIE SGTATAQTIKSHHNVGGLPEDMQFELIEPLNTLFKDEVRALGTELGIPDEIVWRQPFP GPGLGIRVLGEVTEEKLEIVRESDAILREEIANHGLERDIWQYFTVLPDIRSVGVMGD ARTYDYTIGIRAVTSIDGMTSDWARIPWDVLEVISTRIVNEVKHINRVVYDITSKPPA TIEWE*" /label="guaA CDS" gene 616965..618506 /gene="guaA" /locus_tag="BSU_06360" /old_locus_tag="BSU06360" /label="guaA gene" downshifts 618492 /Source="Nicolas_upshifts" /id="D312" /incds=0 /nref=247 /ntot=268 /MaxReadThrough="2.12151" /MaxDrop="7.3702" /score="22.5795134" /energy="-18.5" /TU="NA" /idTUdmin="U492" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 618613..618617 /Source="Nicolas_upshift_promotors" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="promotor_-35" promotor_-10 618633..618652 /Source="Nicolas_upshift_promotors" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="promotor_-10" upshifts 618643 /Source="Nicolas_upshifts" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="upshifts" misc_RNA 618650..618752 /gene="gswC" /locus_tag="BSU_misc_RNA_9" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758; Product type n: RNA" /label="gswC RNA" gene 618650..618752 /gene="gswC" /locus_tag="BSU_misc_RNA_9" /label="gswC gene" downshifts 618778 /Source="Nicolas_upshifts" /id="D313" /incds=0 /nref=11 /ntot=56 /MaxReadThrough="8.01916" /MaxDrop="4.7859" /score="24.3821572" /energy="-11.3" /TU="U493" /idTUdmin="U492" /TUdmin=286 /isTUend="FALSE" /label="downshifts" CDS 618887..620209 /gene="pbuG" /locus_tag="BSU_06370" /old_locus_tag="BSU06370" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:3110131, 11591660, 12923093, 15849754, 16850406, 19446032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3110131, 11591660, 12923093, 15849754, 16850406, 19446032; Product type t : transporter" /codon_start=1 /transl_table=11 /product="hypoxanthine/guanine permease" /protein_id="NP_388518.1" /db_xref="EnsemblGenomes-Gn:BSU06370" /db_xref="EnsemblGenomes-Tr:CAB12456" /db_xref="GOA:O34987" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR026033" /db_xref="SubtiList:BG12811" /db_xref="UniProtKB/Swiss-Prot:O34987" /translation="MKTFFQFDELGTSYRNEIIGGLTTFLSMAYILFVNPITLALESV KDFPEALRIDQGAVFTATALASAAGCILMGLIARYPIAIAPGMGLNAFFAFSVVLGMG ISWQAALSGVFISGLIFVALSLTGFREKIINAIPPELKLAVGAGIGLFITFVGLQGSG IITANPSTLVTIGNIHSGPVLLTIFGVIVTVILMVLRVNAGVFIGMLLTAVAGMIFGL VPVPTQIIGSVPSLAPTFGQAWIHLPDIFSVQMLIVILTFLFVGFFDTAGTLVAVATQ AGLMKENKLPRAGRALLADSSSIVIGAVLGTSTTTSYVESSSGVAAGARSGFAAIVTG ILFLLATFFSPLLSVVTSNVTAPALIIVGALMVAPLGKIAWDKFEVAVPAFLTMIMMP LTYSIATGIAIGFIFYPITMVCKGKAKEVHPIMYGLFVVFILYFIFLK*" /label="pbuG CDS" gene 618887..620209 /gene="pbuG" /locus_tag="BSU_06370" /old_locus_tag="BSU06370" /label="pbuG gene" downshifts 620187 /Source="Nicolas_upshifts" /id="D314" /incds=0 /nref=47 /ntot=153 /MaxReadThrough="4.18958" /MaxDrop="4.86237" /score="42.0241443" /energy="-13.4" /TU="U493" /idTUdmin="U493" /TUdmin="-86" /isTUend="FALSE" /label="downshifts" downshifts 620230 /Source="Nicolas_upshifts" /id="D315" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="3.09696" /MaxDrop="3.87785" /score="42.0241443" /energy="-13.4" /TU="U493" /idTUdmin="U493" /TUdmin="-43" /isTUend="FALSE" /label="downshifts" promotor_-35 620259..620268 /Source="Nicolas_upshift_promotors" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 620279..620419 /Source="Nicolas_S_feature" /locus_tag="new_696054_696194" /HighExp="T1.30H, T1.0H, T2.0H, T0.30H, B60, T2.30H, T-0.40H, T0.0H, T3.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S228" upshifts 620279 /Source="Nicolas_upshifts" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 620281..620296 /Source="Nicolas_upshift_promotors" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 620420..621223 /gene="yebC" /locus_tag="BSU_06380" /old_locus_tag="BSU06380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388519.2" /db_xref="EnsemblGenomes-Gn:BSU06380" /db_xref="EnsemblGenomes-Tr:CAB12457" /db_xref="GOA:O34341" /db_xref="SubtiList:BG12812" /db_xref="UniProtKB/Swiss-Prot:O34341" /translation="MTEERKETFEEEINQSERIDADEEPLSRMSRKASRQSKQKQKQK QKPRQERGESTVKDKLASVWAAINRYCGFAFSILKSPAKTVVTDGFSHYKYGLISMLI FSIIFSIGNWFQLKASWNRPLGFGERHHAFYDGFLVVLVYLLIFFAVMVFAIWAVSRY MMKQKVTFREAAAVLGSLLVPVIAVSILWLIFAIVNIPMLTVLFTVLILFSIFFIIAL YVQRVYQAAQDAPIDYIYCVFAVVAIALLFTAVTWPFISEYITASLIPL*" /label="yebC CDS" gene 620420..621223 /gene="yebC" /locus_tag="BSU_06380" /old_locus_tag="BSU06380" /label="yebC gene" downshifts 621208 /Source="Nicolas_upshifts" /id="D316" /incds=0 /nref=218 /ntot=263 /MaxReadThrough="1.47691" /MaxDrop="7.03926" /score="33.0377004" /energy="-10.7" /TU="NA" /idTUdmin="U494" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 621291..621298 /Source="Nicolas_upshift_promotors" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 621312..621331 /Source="Nicolas_upshift_promotors" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 621318..621381 /Source="Nicolas_S_feature" /locus_tag="new_697093_697156" /HighExp="B60, S2, S7, S8, Lbstat, nit, S4, BC, BT, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S229" upshifts 621318 /Source="Nicolas_upshifts" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="upshifts" CDS 621382..621549 /gene="yebD" /locus_tag="BSU_06390" /old_locus_tag="BSU06390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388520.3" /db_xref="EnsemblGenomes-Gn:BSU06390" /db_xref="EnsemblGenomes-Tr:CAB12458" /db_xref="InterPro:IPR025072" /db_xref="SubtiList:BG12813" /db_xref="UniProtKB/Swiss-Prot:O34904" /translation="MADVLRRAINQKKQFLKTKLLLSEFYQGRGEQLADYTLSELEKE YKSLQKMKKEI*" /label="yebD CDS" gene 621382..621549 /gene="yebD" /locus_tag="BSU_06390" /old_locus_tag="BSU06390" /label="yebD gene" downshifts 621556 /Source="Nicolas_upshifts" /id="D317" /incds=0 /nref=64 /ntot=163 /MaxReadThrough="2.85884" /MaxDrop="5.66286" /score="29.2645456" /energy="-9" /TU="NA" /idTUdmin="U495" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 621600..621606 /Source="Nicolas_upshift_promotors" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 621621..621639 /Source="Nicolas_upshift_promotors" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 621624..621710 /Source="Nicolas_S_feature" /locus_tag="new_697399_697485" /HighExp="Etha, Gly, M9-stat, Sw, B60, S4, S6, LPhT, S3, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.966" /TUlongSig="NA" /TUlongPSig="NA" /label="S230" upshifts 621624 /Source="Nicolas_upshifts" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 621689..621696 /Source="Nicolas_upshift_promotors" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 621710..621729 /Source="Nicolas_upshift_promotors" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 621712 /Source="Nicolas_upshifts" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="upshifts" CDS 621763..622317 /gene="yebE" /locus_tag="BSU_06400" /old_locus_tag="BSU06400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388521.2" /db_xref="EnsemblGenomes-Gn:BSU06400" /db_xref="EnsemblGenomes-Tr:CAB12459" /db_xref="GOA:O34624" /db_xref="InterPro:IPR019264" /db_xref="InterPro:IPR022930" /db_xref="SubtiList:BG12814" /db_xref="UniProtKB/Swiss-Prot:O34624" /translation="MMQTILSNGIAMVLIILIINIVYVSFFTIRMILTLKGQRYLAAG ISTIEILVYVTGLSLVLDNLDQIQNVIAYALGYGLGVIVGMKIEEKLALGYIMVNVIT KELDLDLPKQLREKGYGVTNWVAGGLEGDRTALQILTPRRYELQLYDTIKTLDSKAFI IAYEPKTIHGGFWVKAVKKRRIKE*" /label="yebE CDS" gene 621763..622317 /gene="yebE" /locus_tag="BSU_06400" /old_locus_tag="BSU06400" /label="yebE gene" CDS 622317..622514 /gene="yebG" /locus_tag="BSU_06410" /old_locus_tag="BSU06410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388523.1" /db_xref="EnsemblGenomes-Gn:BSU06410" /db_xref="EnsemblGenomes-Tr:CAB12461" /db_xref="InterPro:IPR025930" /db_xref="SubtiList:BG12816" /db_xref="UniProtKB/Swiss-Prot:O34700" /translation="MAKPKKKKFEVTEQQTIDAVLQQMKEEGYLPVRRMEEPIFMEKK ENGSIQIVPCGKKIVFEGKLI*" /label="yebG CDS" gene 622317..622514 /gene="yebG" /locus_tag="BSU_06410" /old_locus_tag="BSU06410" /label="yebG gene" downshifts 622504 /Source="Nicolas_upshifts" /id="D318" /incds=0 /nref=2 /ntot=91 /MaxReadThrough="2.80904" /MaxDrop="2.65424" /score="17.462689" /energy="-17.6" /TU="U496" /idTUdmin="U497" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 622560..622567 /Source="Nicolas_upshift_promotors" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 622582..622601 /Source="Nicolas_upshift_promotors" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 622584 /Source="Nicolas_upshifts" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 622594..622696 /gene="gswD" /locus_tag="BSU_misc_RNA_10" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758; Product type n: RNA" /label="gswD RNA" gene 622594..622696 /gene="gswD" /locus_tag="BSU_misc_RNA_10" /label="gswD gene" S_feature 622697..622836 /Source="Nicolas_S_feature" /locus_tag="new_698472_698611" /HighExp="MG 10, MG 15, MG t5, BMM, MG 25, MG 5, HPh, GM 45, GM 90, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 0.966" /TUlongSig="NA" /TUlongPSig="NA" /label="S231" CDS 622837..623325 /gene="purE" /locus_tag="BSU_06420" /old_locus_tag="BSU06420" /EC_number="5.4.99.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12787499, 16138311, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N5-carboxyaminoimidazole ribonucleotide mutase" /protein_id="NP_388524.1" /db_xref="EnsemblGenomes-Gn:BSU06420" /db_xref="EnsemblGenomes-Tr:CAB12462" /db_xref="GOA:P12044" /db_xref="InterPro:IPR000031" /db_xref="InterPro:IPR024694" /db_xref="InterPro:IPR033747" /db_xref="InterPro:IPR035893" /db_xref="SubtiList:BG10700" /db_xref="UniProtKB/Swiss-Prot:P12044" /translation="MQPLVGIIMGSTSDWETMKHACDILDELNVPYEKKVVSAHRTPD FMFEYAETARERGIKVIIAGAGGAAHLPGMTAAKTTLPVIGVPVQSKALNGMDSLLSI VQMPGGVPVATTSIGKAGAVNAGLLAAQILSAFDEDLARKLDERRENTKQTVLESSDQ LV*" /label="purE CDS" gene 622837..623325 /gene="purE" /locus_tag="BSU_06420" /old_locus_tag="BSU06420" /label="purE gene" CDS 623318..624460 /gene="purK" /locus_tag="BSU_06430" /old_locus_tag="BSU06430" /EC_number="6.3.4.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8998996, 9683488, 21931218, 25372694; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N5-carboxyaminoimidazole ribonucleotide synthase" /protein_id="NP_388525.2" /db_xref="EnsemblGenomes-Gn:BSU06430" /db_xref="EnsemblGenomes-Tr:CAB12463" /db_xref="GOA:P12045" /db_xref="InterPro:IPR003135" /db_xref="InterPro:IPR005875" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG10701" /db_xref="UniProtKB/Swiss-Prot:P12045" /translation="MSKQIIYPGAVIGIIGGGQLGKMMAVSAKQMGYKVAVVDPVKDS PCGQVADVEITAHYNDREAIRKLAEISDIITYEFENIDYDALHWLKDHAYLPQGSELL LITQNRETEKKAIQSAGCEVAPYSIVKTKNELKQAVQELRLPAVLKTCRGGYDGKGQF VIKEEAQMEQAAALLEHGTCILESWVSFKMELSVIVVRSVNGEISTFPTAENIHHNNI LFQSIVPARVEKGIQQKAADLAVKLADELNLVGPLAVEMFLTEDGELLVNELAPRPHN SGHYTLDLCETSQFEQHIRAVCGLPLGKTDLLKPGMMVNLLGDEVKLVEEDPELLKEA KLYIYGKHEIKKGRKMGHITFMKQPEDEWIQEITNKWMNRDGGQAE*" /label="purK CDS" gene 623318..624460 /gene="purK" /locus_tag="BSU_06430" /old_locus_tag="BSU06430" /label="purK gene" CDS 624457..625752 /gene="purB" /locus_tag="BSU_06440" /old_locus_tag="BSU06440" /EC_number="4.3.2.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9622500, 9683488, 9890879, 11063569, 12787499; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylosuccinate lyase" /protein_id="NP_388526.1" /db_xref="EnsemblGenomes-Gn:BSU06440" /db_xref="EnsemblGenomes-Tr:CAB12464" /db_xref="GOA:P12047" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR004769" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR019468" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="PDB:1F1O" /db_xref="SubtiList:BG10702" /db_xref="UniProtKB/Swiss-Prot:P12047" /translation="MIERYSRPEMSAIWTDENRFQAWLEVEILACEAWAELGVIPKED VKVMRENASFDINRILEIEKDTRHDVVAFTRAVSESLGEERKWVHYGLTSTDVVDTAL SYLLKQANDILLKDLERFVDIIKEKAKEHKYTVMMGRTHGVHAEPTTFGLKLALWHEE MKRNLERFKQAKAGIEVGKISGAVGTYANIDPFVEQYVCEKLGLKAAPISTQTLQRDR HADYMATLALIATSIEKFAVEIRGLQKSETREVEEFFAKGQKGSSAMPHKRNPIGSEN MTGMARVIRGYMMTAYENVPLWHERDISHSSAERIILPDATIALNYMLNRFSNIVKNL TVFPENMKRNMDRTLGLIYSQRVLLALIDTGLTREEAYDTVQPKAMEAWEKQVPFREL VEAEEKITSRLSPEKIADCFDYNYHLKNVDLIFERLGLA*" /label="purB CDS" gene 624457..625752 /gene="purB" /locus_tag="BSU_06440" /old_locus_tag="BSU06440" /label="purB gene" promotor_-10 complement(624762..624781) /Source="Nicolas_upshift_promotors" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(624783) /Source="Nicolas_upshifts" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(624796..624803) /Source="Nicolas_upshift_promotors" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 625826..626551 /gene="purC" /locus_tag="BSU_06450" /old_locus_tag="BSU06450" /EC_number="6.3.2.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2495272, 9683488, 10784038, 12787499, 26118696; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylaminoimidazole succinocarboxamide synthetase" /protein_id="NP_388527.1" /db_xref="EnsemblGenomes-Gn:BSU06450" /db_xref="EnsemblGenomes-Tr:CAB12465" /db_xref="GOA:P12046" /db_xref="InterPro:IPR001636" /db_xref="InterPro:IPR018236" /db_xref="InterPro:IPR028923" /db_xref="InterPro:IPR033934" /db_xref="SubtiList:BG10703" /db_xref="UniProtKB/Swiss-Prot:P12046" /translation="MNIVKNELLYEGKAKKIYKTDDENTLYVVYKDSATAFNGEKKAE ISGKGRLNNEISSLIFKHLHAKGINNHFIERISETEQLIKKVTIVPLEVVVRNVVAGS MSKRLGIPEGTELEQPIIEFYYKDDALGDPLITEDHIWLLKAATPEQVETIKSITTIV NEELQSIFDDCHVRLIDFKLEFGLDAEGQVLLADEISPDTCRLWDKETNEKLDKDLFR RNLGSLTDAYEEIFNRLGGIHHV*" /label="purC CDS" gene 625826..626551 /gene="purC" /locus_tag="BSU_06450" /old_locus_tag="BSU06450" /label="purC gene" CDS 626544..626798 /gene="purS" /locus_tag="BSU_06460" /old_locus_tag="BSU06460" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10784038, 12787499" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10784038, 12787499; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for phosphoribosylformylglycinamidine synthetase activity" /protein_id="NP_388528.1" /db_xref="EnsemblGenomes-Gn:BSU06460" /db_xref="EnsemblGenomes-Tr:CAB12466" /db_xref="GOA:P12049" /db_xref="InterPro:IPR003850" /db_xref="InterPro:IPR036604" /db_xref="PDB:1T4A" /db_xref="PDB:1TWJ" /db_xref="SubtiList:BG10704" /db_xref="UniProtKB/Swiss-Prot:P12049" /translation="MYKVKVYVSLKESVLDPQGSAVQHALHSMTYNEVQDVRIGKYME LTIEKSDRDLDVLVKEMCEKLLANTVIEDYRYEVEEVVAQ*" /label="purS CDS" gene 626544..626798 /gene="purS" /locus_tag="BSU_06460" /old_locus_tag="BSU06460" /label="purS gene" CDS 626795..627478 /gene="purQ" /locus_tag="BSU_06470" /old_locus_tag="BSU06470" /EC_number="6.3.5.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12787499, 15301530, 15301532, 10784038, 9683488" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15301530, 15301532, 10784038, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformylglycinamidine synthetase subunit I" /protein_id="NP_388529.1" /db_xref="EnsemblGenomes-Gn:BSU06470" /db_xref="EnsemblGenomes-Tr:CAB12467" /db_xref="GOA:P12041" /db_xref="InterPro:IPR010075" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10706" /db_xref="UniProtKB/Swiss-Prot:P12041" /translation="MKFAVIVLPGSNCDIDMYHAVKDELGHEVEYVWHEETSLDGFDG VLIPGGFSYGDYLRCGAIARFANIMPAVKQAAAEGKPVLGVCNGFQILQELGLLPGAM RRNKDLKFICRPVELIVQNDETLFTASYEKGESITIPVAHGEGNFYCDDETLATLKEN NQIAFTYGSNINGSVSDIAGVVNEKGNVLGMMPHPERAVDELLGSADGLKLFQSIVKN WRETHVTTA*" /label="purQ CDS" gene 626795..627478 /gene="purQ" /locus_tag="BSU_06470" /old_locus_tag="BSU06470" /label="purQ gene" CDS 627462..629690 /gene="purL" /locus_tag="BSU_06480" /old_locus_tag="BSU06480" /EC_number="6.3.5.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12787499, 15301532, 10784038, 9683488, 21671997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15301532, 10784038, 9683488, 21671997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformylglycinamidine synthetase subunit II" /protein_id="NP_388530.2" /db_xref="EnsemblGenomes-Gn:BSU06480" /db_xref="EnsemblGenomes-Tr:CAB12468" /db_xref="GOA:P12042" /db_xref="InterPro:IPR010074" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10705" /db_xref="UniProtKB/Swiss-Prot:P12042" /translation="MSLLLEPSKEQIKEEKLYQQMGVSDDEFALIESILGRLPNYTEI GIFSVMWSEHCSYKNSKPILRKFPTSGERVLQGPGEGAGIVDIGDNQAVVFKIESHNH PSALEPYQGAATGVGGIIRDVFSMGARPIAVLNSLRFGELTSPRVKYLFEEVVAGIAG YGNCIGIPTVGGEVQFDSSYEGNPLVNAMCVGLINHEDIKKGQAKGVGNTVMYVGAKT GRDGIHGATFASEEMSDSSEEKRSAVQVGDPFMEKLLLEACLEVIQCDALVGIQDMGA AGLTSSSAEMASKAGSGIEMNLDLIPQRETGMTAYEMMLSESQERMLLVIERGREQEI IDIFDKYDLEAVSVGHVTDDKMLRLTHKGEVVCELPVDALAEEAPVYHKPSQEPAYYR EFLETDVPAPQIEDANEMLKALLQQPTIASKEWVYDQYDYMVRTNTVVAPGSDAGVLR IRGTKKALAMTTDCNARYLYLDPEVGGKIAVAEAARNIICSGAEPLAVTDNLNFGNPE KPEIFWQIEKAADGISEACNVLSTPVIGGNVSLYNESNGTAIYPTPVIGMVGLIEDTA HITTQHFKQAGDLVYVIGETKPEFAGSELQKMTEGRIYGKAPQIDLDVELSRQKALLD AIKKGFVQSAHDVSEGGLGVAIAESVMTTENLGANVTVEGEAALLFSESQSRFVVSVK KEHQAAFEATVKDAVHIGEVTADGILAIQNQDGQQMIHAQTKELERVWKGAIPCLLKS KA*" /label="purL CDS" gene 627462..629690 /gene="purL" /locus_tag="BSU_06480" /old_locus_tag="BSU06480" /label="purL gene" downshifts complement(627710) /Source="Nicolas_upshifts" /id="D319" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="0.69202" /MaxDrop="3.99287" /score="-6.56256716" /energy="-16.7" /TU="NA" /idTUdmin="U499" /TUdmin="-3147" /isTUend="FALSE" /label="downshifts" CDS 629666..631096 /gene="purF" /locus_tag="BSU_06490" /old_locus_tag="BSU06490" /EC_number="2.4.2.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9683488, 10049369, 12787499, 16321950, 17981983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9683488, 10049369, 12787499, 16321950, 17981983; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine phosphoribosylpyrophosphate amidotransferase" /protein_id="NP_388531.2" /db_xref="EnsemblGenomes-Gn:BSU06490" /db_xref="EnsemblGenomes-Tr:CAB12469" /db_xref="GOA:P00497" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005854" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR035584" /db_xref="PDB:1AO0" /db_xref="PDB:1GPH" /db_xref="SubtiList:BG10707" /db_xref="UniProtKB/Swiss-Prot:P00497" /translation="MLAEIKGLNEECGVFGIWGHEEAPQITYYGLHSLQHRGQEGAGI VATDGEKLTAHKGQGLITEVFQNGELSKVKGKGAIGHVRYATAGGGGYENVQPLLFRS QNNGSLALAHNGNLVNATQLKQQLENQGSIFQTSSDTEVLAHLIKRSGHFTLKDQIKN SLSMLKGAYAFLIMTETEMIVALDPNGLRPLSIGMMGDAYVVASETCAFDVVGATYLR EVEPGEMLIINDEGMKSERFSMNINRSICSMEYIYFSRPDSNIDGINVHSARKNLGKM LAQESAVEADVVTGVPDSSISAAIGYAEATGIPYELGLIKNRYVGRTFIQPSQALREQ GVRMKLSAVRGVVEGKRVVMVDDSIVRGTTSRRIVTMLREAGATEVHVKISSPPIAHP CFYGIDTSTHEELIASSHSVEEIRQEIGADTLSFLSVEGLLKGIGRKYDDSNCGQCLA CFTGKYPTEIYQDTVLPHVKEAVLTK*" /label="purF CDS" gene 629666..631096 /gene="purF" /locus_tag="BSU_06490" /old_locus_tag="BSU06490" /label="purF gene" S_feature 631097..631197 /Source="Nicolas_S_feature" /locus_tag="new_706872_706972" /HighExp="MG 15, MG 25, MG 10, MG 5, aero, S0, MG t5, Gly, LPh, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S232" CDS 631198..632238 /gene="purM" /locus_tag="BSU_06500" /old_locus_tag="BSU06500" /EC_number="6.3.3.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9683488, 10508786, 12787499, 16321950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylaminoimidazole synthetase" /protein_id="NP_388532.2" /db_xref="EnsemblGenomes-Gn:BSU06500" /db_xref="EnsemblGenomes-Tr:CAB12470" /db_xref="GOA:P12043" /db_xref="InterPro:IPR004733" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10708" /db_xref="UniProtKB/Swiss-Prot:P12043" /translation="MSEAYKNAGVDIEAGYEAVKRMKKHVERTKRLGVMGSLGGFGGM FDLSELSYQKPVLISGTDGVGTKLKLAFSMDKHDTIGVDAVAMCVNDVLAQGAEPLFF LDYLAVGKADPVKIEQIVQGVAEGCEQSGSALVGGETAEMPGLYTADEYDIAGFSVGV AEKDEIVTGEKIEEGHLLIGLSSSGLHSNGFSLVRKVLLDDAELDLDTTYEPFERPLG EELLEPTRIYVKPVLAAVKSGKIDGMAHVTGGGFIENIPRMLPEGLSAEIDHGSWPIP PIFSFLQEYGKLKEEDMFNVFNMGIGFVLAVKEEHLTDVIGTLESHGEKAYLIGRVKK GEGVTFGGAALS*" /label="purM CDS" gene 631198..632238 /gene="purM" /locus_tag="BSU_06500" /old_locus_tag="BSU06500" /label="purM gene" CDS 632235..632822 /gene="purN" /locus_tag="BSU_06510" /old_locus_tag="BSU06510" /EC_number="2.1.2.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9683488, 10569930, 12787499, 19574646; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide formyltransferase" /protein_id="NP_388533.2" /db_xref="EnsemblGenomes-Gn:BSU06510" /db_xref="EnsemblGenomes-Tr:CAB12471" /db_xref="GOA:P12040" /db_xref="InterPro:IPR001555" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR004607" /db_xref="InterPro:IPR036477" /db_xref="SubtiList:BG10709" /db_xref="UniProtKB/Swiss-Prot:P12040" /translation="MKKFAVFASGNGSNFEAIVTRLKEENWDASAALLVCDKPQAKVI ERAEAFHIPSFAFEPKSYENKAAFEQAIIEQLRLHEVELIALAGYMRLIGDTLLQAYG GKIINIHPSLLPAFPGIDAVGQAFRAGVKVAGITVHYVDEGMDTGPIIAQKAIEIDEH DTLETIEQRIHKLEHKWYPSVIKQLLGLNNRGEKA*" /label="purN CDS" gene 632235..632822 /gene="purN" /locus_tag="BSU_06510" /old_locus_tag="BSU06510" /label="purN gene" misc_feature 632245..632259 /Source="Nicolas_upshift_promotors" /id="U500" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.52947052947053" /psig="0.52947052947053" /xcortree=2706 /SigmaFactorBS="aaaaaaggtgaaggcgtcacattcggcggtgcggcactttca tgaaaaagtTTGCGGTATTTGCATcaggaaacggttcaaacttcgaagccatcgtcac g" /listShort="purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 632254 /Source="Nicolas_upshifts" /id="U500" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.52947052947053" /psig="0.52947052947053" /xcortree=2706 /SigmaFactorBS="aaaaaaggtgaaggcgtcacattcggcggtgcggcactttca tgaaaaagtTTGCGGTATTTGCATcaggaaacggttcaaacttcgaagccatcgtcac g" /listShort="purN, purH, purD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(632521..632539) /Source="Nicolas_upshift_promotors" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(632528) /Source="Nicolas_upshifts" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(632555..632560) /Source="Nicolas_upshift_promotors" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 632819..634357 /gene="purH" /locus_tag="BSU_06520" /old_locus_tag="BSU06520" /EC_number="2.1.2.3" /EC_number="3.5.4.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12787499, 1937050, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused phosphoribosylaminoimidazole carboxy formyl formyltransferase; inosine-monophosphate cyclohydrolase" /protein_id="NP_388534.2" /db_xref="EnsemblGenomes-Gn:BSU06520" /db_xref="EnsemblGenomes-Tr:CAB12472" /db_xref="GOA:P12048" /db_xref="InterPro:IPR002695" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR024051" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG10710" /db_xref="UniProtKB/Swiss-Prot:P12048" /translation="MTIKRALISVSDKTNLVPFVKELTELGVEVISTGGTKKLLQENG VDVIGISEVTGFPEIMDGRLKTLHPNIHGGLLAVRGNEEHMAQINEHGIQPIDLVVVN LYPFKETISKEDVTYEEAIENIDIGGPGMLRAASKNHQDVTVIVDPADYSPVLNQIKE EGSVSLQKKRELAAKVFRHTAAYDALIADYLTNVVGEKEPEQFTVTFEKKQSLRYGEN PHQEATFYQTALPVKGSIAQAEQLHGKELSYNNIKDADAAVQIVREFTEPAAVAVKHM NPCGVGTGKTIAEAFDRAFEADKTSIFGGIIALNREVDKATAEALHNIFLEIIIAPSF SQEALDVLTAKKNLRLLTLDVSAAVQKEKQLTSVQGGLLIQDLDMHGFDDAEISIPTK REPNEQEWEDLKLAWKVVKHVKSNAIVLAKDNMTVGVGAGQMNRVGSAKIAIEQAGEK AKGSALGSDAYFPMPDTVEEAAKAGVTAIIQPGGSIRDEDSIKKADEYGIAMVFTGIR HFKH*" /label="purH CDS" gene 632819..634357 /gene="purH" /locus_tag="BSU_06520" /old_locus_tag="BSU06520" /label="purH gene" CDS 634373..635641 /gene="purD" /locus_tag="BSU_06530" /old_locus_tag="BSU06530" /EC_number="6.3.4.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9683488, 12787499, 16321950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9683488, 12787499, 16321950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide synthetase" /protein_id="NP_388535.1" /db_xref="EnsemblGenomes-Gn:BSU06530" /db_xref="EnsemblGenomes-Tr:CAB12473" /db_xref="GOA:P12039" /db_xref="InterPro:IPR000115" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR020559" /db_xref="InterPro:IPR020560" /db_xref="InterPro:IPR020561" /db_xref="InterPro:IPR020562" /db_xref="InterPro:IPR037123" /db_xref="PDB:2XCL" /db_xref="PDB:2XD4" /db_xref="SubtiList:BG10711" /db_xref="UniProtKB/Swiss-Prot:P12039" /translation="MNVLIIGKGGREHTLAWKAAQSSLVENVFAAPGNDGMAASAQLV NIEESDHAGLVSFAKQNQVGLTIVGPEVPLIEGLVDEFEKAGLHVFGPSKAAAIIEGS KQFAKDLMKKYDIPTAEYETFTSFDEAKAYVQEKGAPIVIKADGLAAGKGVTVAMTEE EAIACLHDFLEDEKFGDASASVVIEEYLSGEEFSLMAFVKGEKVYPMVIAQDHKRAFD GDKGPNTGGMGAYSPVPQISEETVRHAVETIVKPAAKAMVQEGRSFTGVLYAGLMLTE NGSKVIEFNARFGDPETQVVLPRMESDLVQVLLDLLDDKEVDLRWKDTAAVSVVLASE GYPESYAKGTPIGSLAAETEQVVVFHAGTKAEGGEFVTNGGRVANVTAFDETFEAARD RVYKAVDEIFKPGLFFRKDIGARALKAAQK*" /label="purD CDS" gene 634373..635641 /gene="purD" /locus_tag="BSU_06530" /old_locus_tag="BSU06530" /label="purD gene" downshifts 635626 /Source="Nicolas_upshifts" /id="D320" /incds=0 /nref=140 /ntot=249 /MaxReadThrough="2.77191" /MaxDrop="5.90939" /score="30.0999687" /energy="-11.4" /TU="NA" /idTUdmin="U500" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(635681..636100) /gene="yezC" /locus_tag="BSU_06540" /old_locus_tag="BSU06540" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388536.2" /db_xref="EnsemblGenomes-Gn:BSU06540" /db_xref="EnsemblGenomes-Tr:CAB12474" /db_xref="GOA:O31497" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR019885" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12874" /db_xref="UniProtKB/Swiss-Prot:O31497" /translation="MDDTDLQILSHLQRNGRLTMVELGKLVGLSSPSAAERVRKLEDK GVITGYSANICYEKLNKHVTAFILMEPKSCKHYAAFATSHPDVAENHRITGMYSYVTK VVTESVHTLEDFIDTSMAHGKPTTLVVLSSSSCHPAF*" /label="yezC CDS" gene complement(635681..636100) /gene="yezC" /locus_tag="BSU_06540" /old_locus_tag="BSU06540" /label="yezC gene" misc_feature complement(636170..636189) /Source="Nicolas_upshift_promotors" /id="U502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3125 /SigmaFactorBS="ccccctctctgattgatggctttattatagaaaaaataagac ggcatccaTATGCTACAATGAAGTTAAAtcaacagcattaccttacgatcaaaggaat t" /listShort="yezC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(636179) /Source="Nicolas_upshifts" /id="U502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3125 /SigmaFactorBS="ccccctctctgattgatggctttattatagaaaaaataagac ggcatccaTATGCTACAATGAAGTTAAAtcaacagcattaccttacgatcaaaggaat t" /listShort="yezC" /GFF_Attribute="listLong" /label="upshifts" CDS 636244..637518 /gene="yecA" /locus_tag="BSU_06550" /old_locus_tag="BSU06550" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26319875, 27723097, 24678831; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative amino acid exporter" /protein_id="NP_388537.2" /db_xref="EnsemblGenomes-Gn:BSU06550" /db_xref="EnsemblGenomes-Tr:CAB12475" /db_xref="GOA:O34560" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12817" /db_xref="UniProtKB/Swiss-Prot:O34560" /translation="MLPELQRSITWIQGTALTIGAVLGCGILILPSVTADTAGPASLF VWVFMSFLSFFLVGTLARLVKIAPSAGGITAYVQLAFQKKAGAILGWIMLGSVPIGVP IIALTGAHYVSYITEAADWQITLIAGCMLAISILLHMRGIQLSANISTLVICVIVFLL VTSIAVSLPHVTIAEFKPFLPHGWSAAGSVSVMIFFSFVGWEMITPLAEEFHRPEKDV PLSLFLAASCVAGLYIMLSFVTVGTHSYGENGEIASLAMLISKGAGESGVYVTVCLAL FITFATIHANIAGFSRMVYALAREGHIPVFFGKLSATKRTPIRVLTAMAAVFGLVLAA HGLFQIDLTTLLKGPSAAFIASYICTMAAALKLLGRRDIGWWMALGAFVACAVIYSFS GWALLYPAVLAAAGYFYMKTKGGHKKKLDHVL*" /label="yecA CDS" gene 636244..637518 /gene="yecA" /locus_tag="BSU_06550" /old_locus_tag="BSU06550" /label="yecA gene" downshifts 637467 /Source="Nicolas_upshifts" /id="D321" /incds=0 /nref=4 /ntot=64 /MaxReadThrough="0.796809999999999" /MaxDrop="2.92696" /score="1.68718502" /energy="-14.2" /TU="NA" /idTUdmin="U498" /TUdmin=1825 /isTUend="FALSE" /label="downshifts" CDS complement(637533..637760) /gene="yezF" /locus_tag="BSU_06559" /old_locus_tag="BSU06559" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097691.1" /db_xref="EnsemblGenomes-Gn:BSU06559" /db_xref="EnsemblGenomes-Tr:CAX52578" /db_xref="GOA:C0H3X3" /db_xref="InterPro:IPR021309" /db_xref="UniProtKB/Swiss-Prot:C0H3X3" /translation="MKPNISLINAVFRIACGLTIMSAASAKFTKKPWCRMHLFYIFMG AMKAGSGILRFCPVTYMFQHSDSGNNEHQNG*" /label="yezF CDS" gene complement(637533..637760) /gene="yezF" /locus_tag="BSU_06559" /old_locus_tag="BSU06559" /label="yezF gene" downshifts complement(637544) /Source="Nicolas_upshifts" /id="D322" /incds=0 /nref=29 /ntot=46 /MaxReadThrough="0.14199" /MaxDrop="6.82335" /score="34.1397958" /energy="-13.9" /TU="NA" /idTUdmin="U504" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(637761..638181) /Source="Nicolas_S_feature" /locus_tag="new_713536_713956_c" /HighExp="S8, S7, S5, S6, S4, ferm, nit, BT, Pyr, T5.0H" /AntisenseName="yerA" /AntisenseCor="0.38264258041500998" /AntisenseRegPval="-10.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S233" promotor_-35 637828..637833 /Source="Nicolas_upshift_promotors" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 637844 /Source="Nicolas_upshifts" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 637847..637866 /Source="Nicolas_upshift_promotors" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 637889..639631 /gene="yerA" /locus_tag="BSU_06560" /old_locus_tag="BSU06560" /EC_number="3.5.4.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23109554; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative adenine deaminase YerA" /protein_id="NP_388538.1" /db_xref="EnsemblGenomes-Gn:BSU06560" /db_xref="EnsemblGenomes-Tr:CAB12476" /db_xref="GOA:O34909" /db_xref="InterPro:IPR006679" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR026912" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG12829" /db_xref="UniProtKB/Swiss-Prot:O34909" /translation="MSERTFNWKNKDIRAQVDVVDSKLLPTLLLRNALVLNPYVKQWL KKNIWIYQDRIVYVGHELPNRAEEIHTIDCEGKYIVPGYIEPHAHPFQIYNPQTLAEY VSQYGTTTFVNDNLFLLLQSGKKKALTILNELKKQPVQYFWWSRYDLQTEVLNEDHVL PFDVRKQWIEHPDVIQGGEMTGWPRLVDGDDLMLHCMQATKKQRKRIEGHFPGASDKT LTKMKLFGADCDHEAMTGDEVMRRLELGYYVSLRNSSIRPDVRKILQELHEKGFRYYD HFFYTTDGATPNFYKGGMTNELIRIALEEGVPAIDAYNMASFNIAKYYQMDDYLGVVG PGRLASLNILEDPLNPNPVTVLSKGTILRENGCDLKAFTKTDWHKGGLVPLELSYDMT MDDLQFSMPMGVKMRNAVIMEPYMIEIDNSMEQLSFDHDESYLTMLDRHGKWRVNTMI KGFASSVQGFVSSFTTTGDIVAIGKNKADMLLAFARMKEIGGGIVLAENGNILHEIPL ALCGCASSEAYEDVLEKEQKLRDLLTERGYEFCDPIYTLLFLQSTHLPYIRITPRGIF DVMKKTVLFPSIMR*" /label="yerA CDS" gene 637889..639631 /gene="yerA" /locus_tag="BSU_06560" /old_locus_tag="BSU06560" /label="yerA gene" promotor_-10 complement(638166..638177) /Source="Nicolas_upshift_promotors" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(638181) /Source="Nicolas_upshifts" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(638191..638197) /Source="Nicolas_upshift_promotors" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 638212 /Source="Nicolas_upshifts" /id="D323" /incds=1 /nref=13 /ntot=109 /MaxReadThrough="7.92321" /MaxDrop="3.44855" /score="1.68718502" /energy="-14.2" /TU="U503" /idTUdmin="U498" /TUdmin=2570 /isTUend="FALSE" /label="downshifts" promotor_-35 639605..639611 /Source="Nicolas_upshift_promotors" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 639623 /Source="Nicolas_upshifts" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 639624..639643 /Source="Nicolas_upshift_promotors" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 639658..640653 /gene="yerB" /locus_tag="BSU_06570" /old_locus_tag="BSU06570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12073041; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388539.1" /db_xref="EnsemblGenomes-Gn:BSU06570" /db_xref="EnsemblGenomes-Tr:CAB12477" /db_xref="GOA:O34968" /db_xref="InterPro:IPR021416" /db_xref="InterPro:IPR023158" /db_xref="InterPro:IPR035328" /db_xref="PDB:2PSB" /db_xref="SubtiList:BG12830" /db_xref="UniProtKB/Swiss-Prot:O34968" /translation="MKKWMTVCALCFVFFLLVSCQQKDAVPDTAKKLKAPLTGLKTEQ KVTERRPVAVVVNNHPKARPQSGLSKADIVIEALAEGQITRFLAIFQSQMPETVGPVR SAREYFVTLSNGFDSIFVHHGWSPGAKKQLESGAADYMNGLDFDGSLFWRADFSKPPH NSYTSYDYIKKAAEQKGYKLKQETNPLLFQTSDAKPANESYNVRVDYGTNNVTNLVEY NYDKKAEFYTRSSDGVITTDRETGKPVAMQNIFIVEASHHIIDQDGRRDIDLESGGKG LLFQHGNVIETDWKQVNGRIVPVKDGKWLPFVPGKTWINIVPDLDAASISKGEGV*" /label="yerB CDS" gene 639658..640653 /gene="yerB" /locus_tag="BSU_06570" /old_locus_tag="BSU06570" /label="yerB gene" CDS 640656..640970 /gene="yerC" /locus_tag="BSU_06580" /old_locus_tag="BSU06580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 23504016, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor-histidine operons" /protein_id="NP_388540.1" /db_xref="EnsemblGenomes-Gn:BSU06580" /db_xref="EnsemblGenomes-Tr:CAB12478" /db_xref="GOA:Q7BVT7" /db_xref="InterPro:IPR000831" /db_xref="InterPro:IPR010921" /db_xref="InterPro:IPR013368" /db_xref="SubtiList:BG12831" /db_xref="UniProtKB/Swiss-Prot:Q7BVT7" /translation="MQIDKLRGKELDQLFNSILSLKDLEECYRFFDDLCTINEIQSLA QRLEVARMLREGNTYHKIETETGASTATISRVKRCLNYGNDAYEMALDRVKETETESS SK*" /label="yerC CDS" gene 640656..640970 /gene="yerC" /locus_tag="BSU_06580" /old_locus_tag="BSU06580" /label="yerC gene" downshifts 640833 /Source="Nicolas_upshifts" /id="D324" /incds=1 /nref=1 /ntot=25 /MaxReadThrough="7.1005" /MaxDrop="2.3494" /score="10.9674476" /energy="-15.8" /TU="U503,U505" /idTUdmin="U503" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" downshifts 640975 /Source="Nicolas_upshifts" /id="D325" /incds=0 /nref=78 /ntot=262 /MaxReadThrough="3.58776" /MaxDrop="5.59364" /score="10.9674476" /energy="-15.8" /TU="U503,U505" /idTUdmin="U503" /TUdmin="-232" /isTUend="FALSE" /label="downshifts" CDS complement(641005..642582) /gene="yerD" /locus_tag="BSU_06590" /old_locus_tag="BSU06590" /EC_number="1.4.1.13" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15805528, 17114254, 19948795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative osmotic shock glutamate synthase subunit (flavoprotein subunit, ferredoxin-dependent)" /protein_id="NP_388541.1" /db_xref="EnsemblGenomes-Gn:BSU06590" /db_xref="EnsemblGenomes-Tr:CAB12479" /db_xref="GOA:O34849" /db_xref="InterPro:IPR002932" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024188" /db_xref="InterPro:IPR027283" /db_xref="SubtiList:BG12832" /db_xref="UniProtKB/Swiss-Prot:O34849" /translation="METIIIALIAFIIGIIAIPIVLFAWIYIKDEKQQEHSILRNYPV IGRFRYILEKIGPELRQYLYSNDNEEQPFSRKEYEQTVISGKYKSRMMGFGSVRDFDK PGYYIRNAMFPKQREEMHVNQTPKIETQIYKMDADNLFKRKEHAEHIKADPYFLHPDD VQVIGEHTCEKPFYVKGLVGQSAMSYGSLGERAVTALSKGLHLAGGTWMNTGEGGLSE YHLKGGADIICQIGPGLFGVRKRNGEFSWEEFKRKSRIDQIKAFELKLAQGAKTRGGH VDGAKVSEEVADIRNVEPGKSIDSPNRFYEFSNPPEMLDFIEKLRDVGQKPVGIKLVA GHPEELHELFSHMQKSGKHPDFITIDGSEGGTGASFYELADTVGLPIMTALPIVDTLL KQYGLRSQLKIFASGKLLTPDKIAVALALGADFVNIARGMMFSVGCIRALVCHTNTCP AGVATTDPKLQKALSVEEKQHRVCNYVISLREGLFNLAAAAGINSPIHFSKEHVVYRK EDGSIINIDNLIHQFVS*" /label="yerD CDS" gene complement(641005..642582) /gene="yerD" /locus_tag="BSU_06590" /old_locus_tag="BSU06590" /label="yerD gene" downshifts complement(641019) /Source="Nicolas_upshifts" /id="D326" /incds=0 /nref=7 /ntot=24 /MaxReadThrough="2.99325" /MaxDrop="5.6389" /score="34.8793815" /energy="-15.8" /TU="U506" /idTUdmin="U506" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(642596..642615) /Source="Nicolas_upshift_promotors" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(642615) /Source="Nicolas_upshifts" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(642630..642636) /Source="Nicolas_upshift_promotors" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 642779..642782 /Source="Nicolas_upshift_promotors" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 642796 /Source="Nicolas_upshifts" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 642799..642818 /Source="Nicolas_upshift_promotors" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 642847..643533 /gene="pcrB" /locus_tag="BSU_06600" /old_locus_tag="BSU06600" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16377641, 21761520, 21214173, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16377641, 21761520, 21214173, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heptaprenylglyceryl-phosphate synthase" /protein_id="NP_388542.1" /db_xref="EnsemblGenomes-Gn:BSU06600" /db_xref="EnsemblGenomes-Tr:CAB12480" /db_xref="GOA:O34790" /db_xref="InterPro:IPR008205" /db_xref="PDB:1VIZ" /db_xref="PDB:3VZX" /db_xref="PDB:3VZY" /db_xref="PDB:3VZZ" /db_xref="PDB:3W00" /db_xref="SubtiList:BG12833" /db_xref="UniProtKB/Swiss-Prot:O34790" /translation="MYDVTEWKHVFKLDPNKDLPDEQLEILCESGTDAVIIGGSDGVT EDNVLRMMSKVRRFLVPCVLEVSAIEAIVPGFDLYFIPSVLNSKNADWIVGMHQKAMK EYGELMSMEEIVAEGYCIANPDCKAAALTEADADLNMDDIVAYARVSELLQLPIFYLE YSGVLGDIEAVKKTKAVLETSTLFYGGGIKDAETAKQYAEHADVIVVGNAVYEDFDRA LKTVAAVKGE*" /label="pcrB CDS" gene 642847..643533 /gene="pcrB" /locus_tag="BSU_06600" /old_locus_tag="BSU06600" /label="pcrB gene" CDS 643595..645814 /gene="pcrA" /locus_tag="BSU_06610" /old_locus_tag="BSU06610" /EC_number="3.6.4.12" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12073041, 12682299, 14594837, 16267290, 26070154; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA helicase" /protein_id="NP_388543.1" /db_xref="EnsemblGenomes-Gn:BSU06610" /db_xref="EnsemblGenomes-Tr:CAB12481" /db_xref="GOA:O34580" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR005751" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="SubtiList:BG12834" /db_xref="UniProtKB/Swiss-Prot:O34580" /translation="MNYISNQLLSGLNPVQQEAVKTTDGPLLLMAGAGSGKTRVLTHR IAYLMAEKHVAPWNILAITFTNKAAREMKERVESILGPGADDIWISTFHSMCVRILRR DIDRIGINRNFSILDTADQLSVIKGILKERNLDPKKFDPRSILGTISSAKNELTEPEE FSKVAGGYYDQVVSDVYADYQKKLLKNQSLDFDDLIMTTIKLFDRVPEVLEFYQRKFQ YIHVDEYQDTNRAQYMLVKQLAERFQNLCVVGDSDQSIYRWRGADITNILSFEKDYPN ASVILLEQNYRSTKRILRAANEVIKNNSNRKPKNLWTENDEGIKISYYRGDNEFGEGQ FVAGKIHQLHSTGKRKLSDIAILYRTNAQSRVIEETLLKAGLNYNIVGGTKFYDRKEI KDILAYLRLVSNPDDDISFTRIVNVPKRGVGATSLEKIASYAAINGLSFFQAIQQVDF IGVSAKAANALDSFRQMIENLTNMQDYLSITELTEEILDKTEYREMLKAEKSIEAQSR LENIDEFLSVTKNFEQKSEDKTLVAFLTDLALIADIDQLDQKEEESGGKDAITLMTLH AAKGLEFPVVFLMGLEEGVFPHSRSLMEEAEMEEERRLAYVGITRAEQELYLTNAKMR TLFGRTNMNPESRFIAEIPDDLLENLNEKKETRATSARKMQPRRGPVSRPVSYASKTG GDTLNWAVGDKAGHKKWGTGTVVSVKGEGEGTELDIAFPSPVGVKRLLAAFAPIEKQ* " /label="pcrA CDS" gene 643595..645814 /gene="pcrA" /locus_tag="BSU_06610" /old_locus_tag="BSU06610" /label="pcrA gene" CDS 645838..647844 /gene="ligA" /locus_tag="BSU_06620" /old_locus_tag="BSU06620" /EC_number="6.5.1.2" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:164915, 11095673, 12682299, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 164915, 11095673, 12682299, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA ligase (NAD-dependent)" /protein_id="NP_388544.1" /db_xref="EnsemblGenomes-Gn:BSU06620" /db_xref="EnsemblGenomes-Tr:CAB12482" /db_xref="GOA:O31498" /db_xref="InterPro:IPR001357" /db_xref="InterPro:IPR001679" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004149" /db_xref="InterPro:IPR004150" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013839" /db_xref="InterPro:IPR013840" /db_xref="InterPro:IPR018239" /db_xref="InterPro:IPR033136" /db_xref="InterPro:IPR036420" /db_xref="SubtiList:BG12835" /db_xref="UniProtKB/Swiss-Prot:O31498" /translation="MDKETAKQRAEELRRTINKYSYEYYTLDEPSVPDAEYDRLMQEL IAIEEEHPDLRTPDSPTQRVGGAVLEAFQKVTHGTPMLSLGNAFNADDLRDFDRRVRQ SVGDDVAYNVELKIDGLAVSLRYEDGYFVRGATRGDGTTGEDITENLKTIRNIPLKMN RELSIEVRGEAYMPKRSFEALNEERIKNEEEPFANPRNAAAGSLRQLDPKIAAKRNLD IFVYSIAELDEMGVETQSQGLDFLDELGFKTNQERKKCGSIEEVITLIDELQAKRADL PYEIDGIVIKVDSLDQQEELGFTAKSPRWAIAYKFPAEEVVTKLLDIELNVGRTGVIT PTAILEPVKVAGTTVSRASLHNEDLIKEKDIRILDKVVVKKAGDIIPEVVNVLVDQRT GEEKEFSMPTECPECGSELVRIEGEVALRCINPECPAQIREGLIHFVSRNAMNIDGLG ERVITQLFEENLVRNVADLYKLTKERVIQLERMGEKSTENLISSIQKSKENSLERLLF GLGIRFIGSKAAKTLAMHFESLENLKKASKEELLAVDEIGEKMADAVITYFHKEEMLE LLNELQELGVNTLYKGPKKVKAEDSDSYFAGKTIVLTGKLEELSRNEAKAQIEALGGK LTGSVSKNTDLVIAGEAAGSKLTKAQELNIEVWNEEQLMGELKK*" /label="ligA CDS" gene 645838..647844 /gene="ligA" /locus_tag="BSU_06620" /old_locus_tag="BSU06620" /label="ligA gene" CDS 647860..649050 /gene="yerH" /locus_tag="BSU_06630" /old_locus_tag="BSU06630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388545.1" /db_xref="EnsemblGenomes-Gn:BSU06630" /db_xref="EnsemblGenomes-Tr:CAB12483" /db_xref="GOA:O34629" /db_xref="InterPro:IPR011426" /db_xref="SubtiList:BG12836" /db_xref="UniProtKB/Swiss-Prot:O34629" /translation="MKKTLALAATAAVLMLSACSSGFGGEKEEEITQKTAKSSEKAIV PKYNISDSYYKMVLPFKAGKARGLTTEQLNTRLDIDEFETGLMRLAQDSFSTDDYLFQ EGQYLDEDTVLSWLARKKTGSDLKKAEKEDKNFKNEGLNPALPSSGSTEEKNESSPIY LASMLEHDYLVRKDKNSIQLGGVMIGLALNSVYYYREKTGDPQKEVEIKDSTLRQQGE KIAQEVINRLRKKDNLKNVPITVALYKQASKTSIVPGNFIAKTEVKAGSTDISNWDDI NEKYVFYPADTTTAEKYPDDTEVFKRFKNSIEEYFPNYTGVVGTALYENDEMKKMKID IPMQFYGKSEVVAFTQFLTGEVMDYYSKSSVDVEVNITSSDGQEAVIIRNAGDKEPTV HIYD*" /label="yerH CDS" gene 647860..649050 /gene="yerH" /locus_tag="BSU_06630" /old_locus_tag="BSU06630" /label="yerH gene" misc_feature complement(648055..648059) /Source="Nicolas_upshift_promotors" /id="U508" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.986013986013986" /psig="0.000999000999001" /xcortree=36 /SigmaFactorBS="atcagccctgtttcaaattcgtcaatgtccagccttgtattc agctgttccgttgttaagCCGCGcgctttgcctgccttaaacggcagcaccattttgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(648059) /Source="Nicolas_upshifts" /id="U508" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.986013986013986" /psig="0.000999000999001" /xcortree=36 /SigmaFactorBS="atcagccctgtttcaaattcgtcaatgtccagccttgtattc agctgttccgttgttaagCCGCGcgctttgcctgccttaaacggcagcaccattttgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 649087..649106 /Source="Nicolas_upshift_promotors" /id="U509" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=3168 /SigmaFactorBS="tcacatttatgactgatagaaaacccttgtgccatattggca caagggttttTATGTTACAATTAACAGGAAaagggaaaatattttcacttctgccgaa a" /listShort="S234, yerI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 649095..649211 /Source="Nicolas_S_feature" /locus_tag="new_724870_724986" /HighExp="LoTm, B60, Lbstat, B36, BI, M9-stat, T1.30H, ferm, T3.30H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S234" upshifts 649095 /Source="Nicolas_upshifts" /id="U509" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=3168 /SigmaFactorBS="tcacatttatgactgatagaaaacccttgtgccatattggca caagggttttTATGTTACAATTAACAGGAAaagggaaaatattttcacttctgccgaa a" /listShort="S234, yerI" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(649159) /Source="Nicolas_upshifts" /id="D327" /incds=0 /nref=2 /ntot=118 /MaxReadThrough="1.21197" /MaxDrop="3.77048" /score="18.5253059" /energy="-17.7" /TU="NA" /idTUdmin="U511" /TUdmin=1122 /isTUend="FALSE" /label="downshifts" CDS 649212..650222 /gene="yerI" /locus_tag="BSU_06640" /old_locus_tag="BSU06640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative kinase" /protein_id="NP_388546.1" /db_xref="EnsemblGenomes-Gn:BSU06640" /db_xref="EnsemblGenomes-Tr:CAB12484" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG12837" /db_xref="UniProtKB/Swiss-Prot:O34640" /translation="MLDVHKDIKKIFHEEQVLAEAAARYGFSKDQVRFLADAENYVYE CMKDNQPYILKITHTIRRSSDYMMGEMEWLRHLAIGGISVAKPLPSLNGKDVEAVPDG NGGSFLLRVYEKAPGQKVDESDWNETLFYELGRYTGSMHSLTKSYKLSNPAFKRQEWD EEEQLKLRKYVPEDQIKVFQQADSLMNELRRLPKSQDNYGLVHADLHHGNFNWDHGKI TAFDFDDIGYNWFVNDISILLYNVLWYPVVPYDDKAAFTEEFMTHFMKGYWEENELDP AWLMIIPDFLRLRHMLIYGLLHQMFDLNTIGEEEKEMLAGFRRDIENGTPITAFDFSA LV*" /label="yerI CDS" gene 649212..650222 /gene="yerI" /locus_tag="BSU_06640" /old_locus_tag="BSU06640" /label="yerI gene" promotor_no_box complement(649229..649329) /Source="Nicolas_upshift_promotors" /id="U510" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=53 /SigmaFactorBS="tttccgcatcagccagaaaacgcacctgatcttttgagaaac cgtatctcgctgcagcttctgccaaaacctgctcttcatgaaatatttttttgatatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(649269) /Source="Nicolas_upshifts" /id="U510" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=53 /SigmaFactorBS="tttccgcatcagccagaaaacgcacctgatcttttgagaaac cgtatctcgctgcagcttctgccaaaacctgctcttcatgaaatatttttttgatatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 650205 /Source="Nicolas_upshifts" /id="D328" /incds=0 /nref=137 /ntot=253 /MaxReadThrough="3.07041" /MaxDrop="5.10987" /score="12.7441524" /energy="-17" /TU="NA" /idTUdmin="U507" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 650249..651053 /Source="Nicolas_S_feature" /locus_tag="new_726024_726828" /HighExp="B60, B36, LoTm, M9-stat, Cold, T1.30H, T0.30H, ferm, Lbstat, LBGstat" /AntisenseName="sapB" /AntisenseCor="-0.57665624439942198" /AntisenseRegPval="-24.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S235" CDS complement(650260..650958) /gene="sapB" /locus_tag="BSU_06650" /old_locus_tag="BSU06650" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 410907, 9043134, 14708580, 27350030, 28181542; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative magnesium transporter" /protein_id="NP_388547.1" /db_xref="EnsemblGenomes-Gn:BSU06650" /db_xref="EnsemblGenomes-Tr:CAB12485" /db_xref="GOA:Q45514" /db_xref="InterPro:IPR003416" /db_xref="SubtiList:BG11845" /db_xref="UniProtKB/Swiss-Prot:Q45514" /translation="MLLSWYIDPDILLKLGIATLIGMVIGLERELKNKPLGLKTCIVI AVSSCMLTIVSINAAYHFPKYYRIMMDPLRLPAQIISGVGFIGAGVILRKSNDVISGL TTSAMIWGAAGLGLATGAGFYKEAFASLLFILISVEFLPWVVRKIGPDRLQEKDIRIR MSLSDKDKMTEILKEMKRRDIKAHSVRIDDLGEKDFPIMEVKVRVHKNRYTTDVYYDI KAIEGVVGVKCDTL*" /label="sapB CDS" gene complement(650260..650958) /gene="sapB" /locus_tag="BSU_06650" /old_locus_tag="BSU06650" /label="sapB gene" downshifts complement(650281) /Source="Nicolas_upshifts" /id="D329" /incds=0 /nref=26 /ntot=129 /MaxReadThrough="2.5379" /MaxDrop="3.83708" /score="20.8493264" /energy="-16.2" /TU="NA" /idTUdmin="U511" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(650978..650996) /Source="Nicolas_upshift_promotors" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(650999) /Source="Nicolas_upshifts" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(651012..651017) /Source="Nicolas_upshift_promotors" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(651065..652543) /gene="opuE" /locus_tag="BSU_06660" /old_locus_tag="BSU06660" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9701821, 11902719, 14996799, 15849754, 16850406, 17183215, 22685134" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9701821, 11902719, 14996799, 15849754, 16850406, 17183215, 22685134; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proline transporter" /protein_id="NP_388548.1" /db_xref="EnsemblGenomes-Gn:BSU06660" /db_xref="EnsemblGenomes-Tr:CAB12486" /db_xref="GOA:O06493" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR011851" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG12641" /db_xref="UniProtKB/Swiss-Prot:O06493" /translation="MSIEIIISLGIYFIAMLLIGWYAFKKTTDINDYMLGGRGLGPFV TALSAGAADMSGWMLMGVPGAMFATGLSTLWLALGLTIGAYSNYLLLAPRLRAYTEAA DDAITIPDFFDKRFQHSSSLLKIVSALIIMIFFTLYTSSGMVSGGRLFESAFGADYKL GLFLTTAVVVLYTLFGGFLAVSLTDFVQGAIMFAALVLVPIVAFTHVGGVAPTFHEID AVNPHLLDIFKGASVISIISYLAWGLGYYGQPHIIVRFMAIKDIKDLKPARRIGMSWM IITVLGSVLTGLIGVAYAHKFGVAVKDPEMIFIIFSKILFHPLITGFLLSAILAAIMS SISSQLLVTASAVTEDLYRSFFRRKASDKELVMIGRLSVLVIAVIAVLLSLNPNSTIL DLVGYAWAGFGSAFGPAILLSLYWKRMNEWGALAAMIVGAATVLIWITTGLAKSTGVY EIIPGFILSMIAGIIVSMITKRPAKASYRLFGVMEKLLKRKK*" /label="opuE CDS" gene complement(651065..652543) /gene="opuE" /locus_tag="BSU_06660" /old_locus_tag="BSU06660" /label="opuE gene" downshifts complement(651079) /Source="Nicolas_upshifts" /id="D330" /incds=0 /nref=43 /ntot=142 /MaxReadThrough="5.35634" /MaxDrop="4.34381" /score="9.43100511" /energy="-13.8" /TU="U512,U513" /idTUdmin="U511" /TUdmin="-798" /isTUend="FALSE" /label="downshifts" upshifts complement(651931) /Source="Nicolas_upshifts" /id="U512" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.475524475524476" /psig="0.475524475524476" /xcortree=138 /SigmaFactorBS="gacttcgtgcagggtgcgatcatgtttgcagcactagtgctt gtGCCGATCGTTGCTTttacccatgtgggcggcgttgctccgactttccatgaaatcg a" /listShort="sapB" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(651934..651947) /Source="Nicolas_upshift_promotors" /id="U512" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.475524475524476" /psig="0.475524475524476" /xcortree=138 /SigmaFactorBS="gacttcgtgcagggtgcgatcatgtttgcagcactagtgctt gtGCCGATCGTTGCTTttacccatgtgggcggcgttgctccgactttccatgaaatcg a" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature complement(652544..652674) /Source="Nicolas_S_feature" /locus_tag="new_728319_728449_c" /HighExp="Salt, HiOs, Etha, Gly, MG 25, MG 45, M9-exp, MG t5, MG 15, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.954" /TUlongSig="NA" /TUlongPSig="NA" /label="S236" promotor_-10 complement(652665..652683) /Source="Nicolas_upshift_promotors" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(652674) /Source="Nicolas_upshifts" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(652698..652704) /Source="Nicolas_upshift_promotors" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 652805..652808 /Source="Nicolas_upshift_promotors" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 652823..652956 /Source="Nicolas_S_feature" /locus_tag="new_728598_728731" /HighExp="G180, G150, LBGexp, Oxctl, Paraq, dia0, G135, Lbexp, H2O2, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S237" upshifts 652823 /Source="Nicolas_upshifts" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 652825..652844 /Source="Nicolas_upshift_promotors" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 652957..653247 /gene="gatC" /locus_tag="BSU_06670" /old_locus_tag="BSU06670" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9342321, 11445070, 12682299, 25005615" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9342321, 11445070, 12682299, 25005615; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit C)" /protein_id="NP_388549.1" /db_xref="EnsemblGenomes-Gn:BSU06670" /db_xref="EnsemblGenomes-Tr:CAB12487" /db_xref="GOA:O06492" /db_xref="InterPro:IPR003837" /db_xref="InterPro:IPR036113" /db_xref="SubtiList:BG12838" /db_xref="UniProtKB/Swiss-Prot:O06492" /translation="MSRISIEEVKHVAHLARLAITEEEAKMFTEQLDSIISFAEELNE VNTDNVEPTTHVLKMKNVMREDEAGKGLPVEDVMKNAPDHKDGYIRVPSILD*" /label="gatC CDS" gene 652957..653247 /gene="gatC" /locus_tag="BSU_06670" /old_locus_tag="BSU06670" /label="gatC gene" CDS 653263..654720 /gene="gatA" /locus_tag="BSU_06680" /old_locus_tag="BSU06680" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445070, 12682299, 9342321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445070, 12682299, 9342321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit A)" /protein_id="NP_388550.1" /db_xref="EnsemblGenomes-Gn:BSU06680" /db_xref="EnsemblGenomes-Tr:CAB12488" /db_xref="GOA:O06491" /db_xref="InterPro:IPR000120" /db_xref="InterPro:IPR004412" /db_xref="InterPro:IPR020556" /db_xref="InterPro:IPR023631" /db_xref="InterPro:IPR036928" /db_xref="SubtiList:BG12839" /db_xref="UniProtKB/Swiss-Prot:O06491" /translation="MSLFDHKITELKQLIHKKEIKISDLVDESYKRIQAVDDKVQAFL ALDEERARAYAKELDEAVDGRSEHGLLFGMPIGVKDNIVTKGLRTTCSSKILENFDPI YDATVVQRLQDAEAVTIGKLNMDEFAMGSSTENSAYKLTKNPWNLDTVPGGSSGGSAA AVAAGEVPFSLGSDTGGSIRQPASFCGVVGLKPTYGRVSRYGLVAFASSLDQIGPITR TVEDNAFLLQAISGVDKMDSTSANVDVPDFLSSLTGDIKGLKIAVPKEYLGEGVGKEA RESVLAALKVLEGLGATWEEVSLPHSKYALATYYLLSSSEASANLARFDGIRYGYRTD NADNLIDLYKQTRAEGFGNEVKRRIMLGTFALSSGYYDAYYKKAQKVRTLIKKDFEDV FEKYDVIVGPTTPTPAFKIGENTKDPLTMYANDILTIPVNLAGVPGISVPCGLADGLP LGLQIIGKHFDESTVYRVAHAFEQATDHHKAKPEL*" /label="gatA CDS" gene 653263..654720 /gene="gatA" /locus_tag="BSU_06680" /old_locus_tag="BSU06680" /label="gatA gene" CDS 654734..656164 /gene="gatB" /locus_tag="BSU_06690" /old_locus_tag="BSU06690" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445070, 12682299, 9342321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445070, 12682299, 9342321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit B)" /protein_id="NP_388551.2" /db_xref="EnsemblGenomes-Gn:BSU06690" /db_xref="EnsemblGenomes-Tr:CAB12489" /db_xref="GOA:O30509" /db_xref="InterPro:IPR003789" /db_xref="InterPro:IPR004413" /db_xref="InterPro:IPR006075" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR017958" /db_xref="InterPro:IPR017959" /db_xref="InterPro:IPR018027" /db_xref="InterPro:IPR023168" /db_xref="SubtiList:BG12840" /db_xref="UniProtKB/Swiss-Prot:O30509" /translation="MNFETVIGLEVHVELKTKSKIFSSSPTPFGAEANTQTSVIDLGY PGVLPVLNKEAVEFAMKAAMALNCEIATDTKFDRKNYFYPDNPKAYQISQFDKPIGEN GWIEIEVGGKTKRIGITRLHLEEDAGKLTHTGDGYSLVDFNRQGTPLVEIVSEPDIRT PEEAYAYLEKLKSIIQYTGVSDCKMEEGSLRCDANISLRPIGQEEFGTKTELKNLNSF AFVQKGLEHEEKRQEQVLLSGGVIQQETRRYDEATKKTILMRVKEGSDDYRYFPEPDL VELYIDDEWKERVKASIPELPDERRKRYIEELGLPAYDAMVLTLTKEMADFFEETVQK GAEAKQASNWLMGEVSAYLNAEQKELADVALTPEGLAGMIKLIEKGTISSKIAKKVFK ELIEKGGDAEKIVKEKGLVQISDEGVLLKLVTEALDNNPQSIEDFKNGKDRAIGFLVG QIMKASKGQANPPMVNKILLEEIKKR*" /label="gatB CDS" gene 654734..656164 /gene="gatB" /locus_tag="BSU_06690" /old_locus_tag="BSU06690" /label="gatB gene" downshifts 656145 /Source="Nicolas_upshifts" /id="D331" /incds=0 /nref=257 /ntot=266 /MaxReadThrough="1.62334" /MaxDrop="8.77378" /score="26.1218607" /energy="-9.6" /TU="NA" /idTUdmin="U514" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(656179..657048) /gene="yerO" /locus_tag="BSU_06700" /old_locus_tag="BSU06700" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388552.1" /db_xref="EnsemblGenomes-Gn:BSU06700" /db_xref="EnsemblGenomes-Tr:CAB12490" /db_xref="GOA:O31500" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG12841" /db_xref="UniProtKB/Swiss-Prot:O31500" /translation="MNEKKERIIKTSIRLFAKKGFAATTIQEIASECGISKGAFYLHF KSKEALLLSACEYYIGMSMNKMKNIEEDLAGKPPKEVLKKQIGAQFEDFRDHKDFIVL LLTENIIPENQEIKQYFYKVTMETDKLYRNALLVSYGEGIERYVADLSIMARGIVHSY MNVMVFNGELNIDAEEISAFIIERLDDLVQGLSRSALNPIVSKDIFNPMPAGKDQLLE DIQKVKENSTLPEDITVSLDVIEEELTQDKPRKPIIKGMLSNLAGTNDKEVERLRALI LSLSQFDHKKSSL*" /label="yerO CDS" gene complement(656179..657048) /gene="yerO" /locus_tag="BSU_06700" /old_locus_tag="BSU06700" /label="yerO gene" downshifts complement(656221) /Source="Nicolas_upshifts" /id="D332" /incds=0 /nref=122 /ntot=211 /MaxReadThrough="2.21801" /MaxDrop="4.89305" /score="32.2694333" /energy="-11.4" /TU="NA" /idTUdmin="U517" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 656838..656843 /Source="Nicolas_upshift_promotors" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="promotor_-35" promotor_-10 656859..656877 /Source="Nicolas_upshift_promotors" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="promotor_-10" upshifts 656871 /Source="Nicolas_upshifts" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="upshifts" S_feature complement(657049..657123) /Source="Nicolas_S_feature" /locus_tag="new_732824_732898_c" /HighExp="C30, S1, T3.0H, T4.0H, Salt, T5.0H, T2.0H, T3.30H, MG 150, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S238" promotor_-35 657101..657108 /Source="Nicolas_upshift_promotors" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(657117..657136) /Source="Nicolas_upshift_promotors" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 657123 /Source="Nicolas_upshifts" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 657124..657143 /Source="Nicolas_upshift_promotors" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(657130) /Source="Nicolas_upshifts" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(657151..657158) /Source="Nicolas_upshift_promotors" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="promotor_-35" CDS 657180..660338 /gene="srfP" /locus_tag="BSU_06710" /old_locus_tag="BSU06710" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11709341, 15066026, 15941986, 25366377" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11709341, 15066026, 15941986, 25366377; Product type t: transporter" /codon_start=1 /transl_table=11 /product="surfactin exporter involved in surfactin self-resistance" /protein_id="NP_388553.2" /db_xref="EnsemblGenomes-Gn:BSU06710" /db_xref="EnsemblGenomes-Tr:CAB12491" /db_xref="GOA:O31501" /db_xref="InterPro:IPR001036" /db_xref="InterPro:IPR027463" /db_xref="SubtiList:BG12842" /db_xref="UniProtKB/Swiss-Prot:O31501" /translation="MNHVINFVLKNKFAVWLMTIIVTAAGLYAGMNMKQESIPDVNMP YLTISTTYPGATPSQVADEVTKPVEQAVQNLDGVSVVTSTSYENASSVMIEYDYEKDM DKAKTEAAEALENVNLPDDAKDPEISRYSLNSFPILTLSVSSDKDNLQELTKQVEDSL VSKLEGIEGVASVQVSGQQVEEVEFSFKEDKLKEYGLDEDTVKQVIQGSDVTTPLGLY TFGNEEKSVVVSGDIETIKDLKNMRIPTASASSAGSSAASQAGAQSAQAAQSAQAAAQ VQQSASTAVPTVKLSDIATIKDVKKAESVSRTNGKDSIGINIVKANDANTVEVADDVK AELKKFKEDHKGFNYSATLDMAEPITQSVDTMLSKAIFGAIFAIVIILLFLRDIKSTL ISVVSIPLSLLIALLVLQQLDITLNIMTLGAMTVAIGRVVDDSIVVIENIYRRMRLKD EPLRGKALVREATKEMFKPIMSSTIVTIAVFLPLALVGGQIGELFIPFALTIVFALAA SLVISITLVPMLAHSLFKKSLTGAPIKAKEHKPGRLANIYKKVLNWALSHKWITSIIA VLMLLGSLFLVPLIGASYLPSEEEKTMQLTYSPEPGETKKEAENEAEKAEKILLDRKH VDTVQYSLGSGSPLAGGDSNGALFYIKYESDTPDFDKEKDNVLKEIQKQSDRGEWKSQ DFSSSGNNNELTYYVYGDSENDIKDTVKDIEKIMKDEKDLKNVNSGLSSTYDEYTFVA DQEKLSKLGLTASQISQALMSQTSQEPLTTVKKDGKELDVNIKTEKDEYKSVKDLENK KITSATGQEVKIGDVAKVKEGSTSDTVSKRDGKVYADVTGEVTSDNVTAVSAAIQKKI DKLDHPDNVSIDTGGVSADIADSFTKLGLAMLAAIAIVYLVLVITFGGALAPFAILFS LPFTVIGALVGLYVSGETISLNAMIGMLMLIGIVVTNAIVLIDRVIHKEAEGLSTREA LLEAGSTRLRPILMTAIATIGALIPLALGFEGGSQVISKGLGVTVIGGLISSTLLTLL IVPIVYEVLAKFRKKKPGTEEE*" /label="srfP CDS" gene 657180..660338 /gene="srfP" /locus_tag="BSU_06710" /old_locus_tag="BSU06710" /label="srfP gene" downshifts 660325 /Source="Nicolas_upshifts" /id="D333" /incds=0 /nref=76 /ntot=243 /MaxReadThrough="3.70478" /MaxDrop="4.6624" /score="-3.65521193" /energy="-12.7" /TU="U516" /idTUdmin="U516" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" promotor_-35 660577..660580 /Source="Nicolas_upshift_promotors" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 660595..660614 /Source="Nicolas_upshift_promotors" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 660603 /Source="Nicolas_upshifts" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="upshifts" CDS 660661..661572 /gene="dagK" /locus_tag="BSU_06720" /old_locus_tag="BSU06720" /EC_number="2.7.1.107" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10220166, 12682299, 17535816, 22224599, 24700682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 12682299, 17535816, 22224599, 24700682; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diacylglycerol kinase" /protein_id="NP_388554.1" /db_xref="EnsemblGenomes-Gn:BSU06720" /db_xref="EnsemblGenomes-Tr:CAB12492" /db_xref="GOA:O31502" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG12843" /db_xref="UniProtKB/Swiss-Prot:O31502" /translation="MKRARIIYNPTSGREIFKKHLAQVLQKFEQAGYETSTHATTCAG DATHAAKEAALREFDLIIAAGGDGTINEVVNGLAPLDNRPTLGVIPVGTTNDFARALG IPREDILKAADTVINGVARPIDIGQVNGQYFINIAGGGRLTELTYDVPSKLKTMLGQL AYYLKGMEMLPSLRPTEVEIEYDGKLFQGEIMLFLVTLTNSVGGFEKLAPDSSLNDGM FDLMILKKANLAEFIRVATMALRGEHINDQHIIYTKANRVKVNVSEKMQLNLDGEYGG MLPGEFVNLYRHIHVVMPKEKAEQLDD*" /label="dagK CDS" gene 660661..661572 /gene="dagK" /locus_tag="BSU_06720" /old_locus_tag="BSU06720" /label="dagK gene" S_feature 661573..661827 /Source="Nicolas_S_feature" /locus_tag="new_737348_737602" /HighExp="H2O2, Oxctl, Paraq, G180, Cold, C30, G150, G135, Heat, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S239" CDS 661828..663207 /gene="rlmCD" /locus_tag="BSU_06730" /old_locus_tag="BSU06730" /EC_number="2.1.1.189" /EC_number="2.1.1.190" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:21824914" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21824914; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methyltransferase of m5U747 and m5U1939 in 23S RNA" /protein_id="NP_388555.1" /db_xref="EnsemblGenomes-Gn:BSU06730" /db_xref="EnsemblGenomes-Tr:CAB12493" /db_xref="GOA:O31503" /db_xref="InterPro:IPR001566" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR010280" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030390" /db_xref="InterPro:IPR030391" /db_xref="SubtiList:BG12826" /db_xref="UniProtKB/Swiss-Prot:O31503" /translation="MKMKPPVEKNEYYDVTFEDLTHEGAGVAKVQGFPIFVPNALPEE KAQIKVTRVKKGFAFGRLIELKEESPHRTDAPCPIYKQCGGCQLQHMTYEGQLLFKQK QVKDVLERIGKLDLSKVTVHPTLGMEDPWNYRNKAQVPVGEREGGLVAGFYQQRSHDI IDMSACLIQQSKNDEAVQAVKDICANYGVKAYNEERHKGWLRHIMVRYGVVTGEMMIV FITRTSDFPHKAKIIEDITAQFPHVKSIVQNINPNKTNVIFGNETNVIWGEEYIYDLI GDVKFAISARSFYQVNPEQTKVLYDKALEYAELQGEETVIDAYCGIGTISLFLAKQAK KVYGVEIVPEAIEDAKRNAELNGNTNAEFAVGEAETVIPKWYEEGITADTLVVDPPRK GCDEALLRTIVEMKPKRVVYVSCNPGTLARDLRVLEDGGYVTREVQPVDMFPHTNHVE CCVLIKLKE*" /label="rlmCD CDS" gene 661828..663207 /gene="rlmCD" /locus_tag="BSU_06730" /old_locus_tag="BSU06730" /label="rlmCD gene" S_feature 663208..663800 /Source="Nicolas_S_feature" /locus_tag="new_738983_739575" /HighExp="Cold, H2O2, G135, G150, Oxctl, G180, C30, Paraq, LPh, HPh" /AntisenseName="yefB" /AntisenseCor="0.24913678485492899" /AntisenseRegPval="-4.4000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S240" CDS complement(663220..664122) /gene="yefB" /locus_tag="BSU_06740" /old_locus_tag="BSU06740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1779754, 1762151; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative site-specific recombinase / invertase; HGT island" /protein_id="NP_388556.1" /db_xref="EnsemblGenomes-Gn:BSU06740" /db_xref="EnsemblGenomes-Tr:CAB12494" /db_xref="GOA:O34574" /db_xref="InterPro:IPR011109" /db_xref="InterPro:IPR025827" /db_xref="SubtiList:BG12827" /db_xref="UniProtKB/Swiss-Prot:O34574" /translation="MYNEGVTSPSQLARKKNATDKWHGSSIRKILENPHYTGTLQQCR EYRPSVTSKRRRSVNLENQIIIEKSHEPIIPLEDFLIVQEILITRKRRRPQAEVHLFT NTAVCKDCRRSMHFKKNRKGYVCGSYNKHGLKACSDHYVSEIDLTDKVITNLNKIYLK FSKENYFKELSEKALKYKEKIESKIIEINEKLNDKKRDKSNLVISLANGVISKEDYQL AINITNEDISNFETTLHQLSKDLEFQKIEKEIIDFKKSLDKFMKEGTLTPEMLHLLVD EIEVHANGTIEINYRFREPTVPSA*" /label="yefB CDS" gene complement(663220..664122) /gene="yefB" /locus_tag="BSU_06740" /old_locus_tag="BSU06740" /label="yefB gene" downshifts 663757 /Source="Nicolas_upshifts" /id="D334" /incds=1 /nref=1 /ntot=30 /MaxReadThrough="4.70474" /MaxDrop="2.82299" /score="-8.81916201" /energy="-8.8" /TU="U518" /idTUdmin="U516" /TUdmin=3322 /isTUend="FALSE" /label="downshifts" S_feature 663802..664102 /Source="Nicolas_S_feature" /locus_tag="new_739577_739877" /HighExp="H2O2, Cold, G180, G135, G150, Paraq, Oxctl, C30, LPh, LBGexp" /AntisenseName="yefB" /AntisenseCor="0.202214664414261" /AntisenseRegPval="-3.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S241" CDS 664103..664438 /gene="yefC" /locus_tag="BSU_06750" /old_locus_tag="BSU06750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative resolvase; HGT island" /protein_id="NP_388557.2" /db_xref="EnsemblGenomes-Gn:BSU06750" /db_xref="EnsemblGenomes-Tr:CAB12495" /db_xref="GOA:O35034" /db_xref="InterPro:IPR006119" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036162" /db_xref="SubtiList:BG12828" /db_xref="UniProtKB/Swiss-Prot:O35034" /translation="MTPSLYNPLAIASKPFPAIYSEKILIFTIFSAFAEFERDMIVER TQEGKMLAKQNPDFREGRPKKFTKQQINHALTLLENHSYKQVEDMTGISVSTLVRAKK KKAAEAING*" /label="yefC CDS" gene 664103..664438 /gene="yefC" /locus_tag="BSU_06750" /old_locus_tag="BSU06750" /label="yefC gene" S_feature 664439..664512 /Source="Nicolas_S_feature" /locus_tag="new_740214_740287" /HighExp="G180, H2O2, G150, Cold, G135, Paraq, Oxctl, C30, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S242" CDS 664513..667152 /gene="yeeA" /locus_tag="BSU_06760" /old_locus_tag="BSU06760" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative restriction type II methylase; HGT island" /protein_id="NP_388558.1" /db_xref="EnsemblGenomes-Gn:BSU06760" /db_xref="EnsemblGenomes-Tr:CAB12496" /db_xref="GOA:O31504" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12818" /db_xref="UniProtKB/Swiss-Prot:O31504" /translation="MALIDLEDKIAEIVNREDHSDFLYELLGVYDVPRATITRLKKGN QNLTKRVGEVHLKNKVWFKEAKKGKLFDALIDIEQQVEYLSAKPRYLLVTDYDGVLAK DTKTLEALDVKFEELPQYFDFFLAWKGIEKVEFEKENPADIKAAERFARIYDVLRKEN NIIETNRGLDLFLIRLLFCFFAEDTDIFKRNSFTNLIKTLTEEDGSNLNKLFADLFIV LDKNERDDVPSYLKEFPYVNGQLFTEPHTELEFSAKSRKLIIECGELLNWAKINPDIF GSMIQAVASEESRSYLGMHYTSVPNIMKVIKPLFLDKLNQSFLDAYDDYTKLENLLTR IGKIKFFDPACGSGNFLIITYKELRRMEINIIKRLQELLGEYLYVPSVTLSQFYGIEI EDFAHDVAKLSLWIAEHQMNEELKNEVHNAVRPTLPLHTAGDIRCANAIRVEWTEVCP AQGSEEVYVFGNPPYLGSKKQNKEHKSDMLSIFGKVKNGKMLDYISAWFYFGAKYAST TNAKVAFVSTNSVTQGEQVSILWNELFKFGIQINFAYKSFKWANNAKNNAAVIVVIVG FGPLDTKVNKYLFVDETKKLVSNISPYLTDGENILVSSRTKPISDLPKLHFGNMPNDG GGLLFTITEYTDAINKYPELVPYFKKFIGSVEFINGGLRYCLWLNEAKYEKIKSNPLI QERISISKNHREKSTDKGTNKLALTPWKFRDTHETTNYSIVVPSVSSENRFYIPMGLA GADTILSNLIYVIYDAEIYLLGILMSRMHMTWVKAVAGRLKTDYRYSAGLCYNTFPIP ELSTRRKNEIEEAILEILDLREEQGGTLAELYNPSTMPIELKVAHEKLDGIVERAYRQ KQFESDEERLEVLLKLYQEMTER*" /label="yeeA CDS" gene 664513..667152 /gene="yeeA" /locus_tag="BSU_06760" /old_locus_tag="BSU06760" /label="yeeA gene" CDS 667164..668963 /gene="yeeB" /locus_tag="BSU_06770" /old_locus_tag="BSU06770" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA helicase / endonuclease; HGT island" /protein_id="NP_388559.2" /db_xref="EnsemblGenomes-Gn:BSU06770" /db_xref="EnsemblGenomes-Tr:CAB12497" /db_xref="GOA:O34469" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12819" /db_xref="UniProtKB/Swiss-Prot:O34469" /translation="MENIIEINYNQTGKSKKTNEYGMREMQARAFEKRNSQYLLVKAP PASGKSRALMFIGLDKLINQGLRKVIVAVPERSIGSSFKNTDLKSYGFFENWKVDPRN NLTVGGDNSKVKSFVRFMESDDQVLICTHSTLRFAFEKIDDKAFDNCLLAIDEFHHVS ADVNSRLGELLRSIIHNSSAHIVAMTGSYFRGDSVPILLPEDEELFDKVTYSYYEQLD GYEYLKGFGIGYHFYQGQYTSAINEVLDTNKKTIVHIPNVNSGESTKDKYDEVGKILD MIGEVEYQDDDTGIIYVKRHSDGKTLKIADLVDDQVGRENVVAYLRNIEALDDLDIII ALGMAKEGFDWPFCEHTLTVGYRGSLTEIVQIIGRCTRDSYNKTYAQFTNLIAMPDAK DEVVTYTVNTMLKAISASLLMEQVLTPDFKFKRRRNESEKSSTTGELFVKGLKEPSTE NVKKIIENDINDLKAKIMQDSQVQKTFSGEVDPKVLNKVLIPKVIQKVYPNLSDEEIE EVRQHVVLDTVMKGAKSEVVGSKEFIRMADKFINIEDLDINLIDSINPFQKAFEVLSK ELNSPVLKLIQETIDAKRINFDEDELVFIWPKV*" /label="yeeB CDS" gene 667164..668963 /gene="yeeB" /locus_tag="BSU_06770" /old_locus_tag="BSU06770" /label="yeeB gene" promotor_-10 complement(667404..667419) /Source="Nicolas_upshift_promotors" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(667419) /Source="Nicolas_upshifts" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(667431..667440) /Source="Nicolas_upshift_promotors" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 668964..669075 /Source="Nicolas_S_feature" /locus_tag="new_744739_744850" /HighExp="Cold, G180, G135, G150, H2O2, Paraq, HPh, LPh, Oxctl, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S243" CDS 669076..670224 /gene="yeeC" /locus_tag="BSU_06780" /old_locus_tag="BSU06780" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="NP_388560.2" /db_xref="EnsemblGenomes-Gn:BSU06780" /db_xref="EnsemblGenomes-Tr:CAB12498" /db_xref="InterPro:IPR018306" /db_xref="SubtiList:BG12820" /db_xref="UniProtKB/Swiss-Prot:O34352" /translation="MASNRYHSINEIMESQLFYQITTPPKKTQKAQYDPEVEKFLEII EFVKENGREPQKVPTDLTERSLASRLIGIRKDPDRMEYLKEYDEIGLLEVRSKELTIP KISSIDDILKSGLSALLGDNLNNDITRSIFDTSSLQKVTTMPEYVAKRKKIKDFGKFE ELFKKCHKEITEGKRKILTFKNEQDIQSNSFYILKGVLLYVEDVGERKKAKGKTNARL RCIFENGTESDMLLRSLSAELYKHGRRVTDNEDTLLDNVREDDVSTGFIYVLKSLSTD PQISSIKNLYKIGFTTGSVENRIRNAENQSTYLYAPVEIVTTYQVFNMNASKFETAIH HALANNNLDVSILGANGKMLVPKEWFVVTLEDLQAVIDEIVMMVHLYD*" /label="yeeC CDS" gene 669076..670224 /gene="yeeC" /locus_tag="BSU_06780" /old_locus_tag="BSU06780" /label="yeeC gene" S_feature 670225..671414 /Source="Nicolas_S_feature" /locus_tag="new_746000_747189" /HighExp="Cold, G135, H2O2, G180, G150, LPh, C30, HPh, BMM, Paraq" /AntisenseName="yeeD" /AntisenseCor="-0.41772847620445203" /AntisenseRegPval="-12.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S244" CDS complement(670486..670791) /gene="yeeD" /locus_tag="BSU_06790" /old_locus_tag="BSU06790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="NP_388561.1" /db_xref="EnsemblGenomes-Gn:BSU06790" /db_xref="EnsemblGenomes-Tr:CAB12499" /db_xref="SubtiList:BG12821" /db_xref="UniProtKB/Swiss-Prot:O34950" /translation="MTVRKELIKQINLTITVIKTINQKNPTPMVKNILKRYEEAKEFI LQSSDGKFEEDLSKVRNKLDTLTRAYLESANDYMNPMLKEMHKTEKLLKEYDETTQS* " /label="yeeD CDS" gene complement(670486..670791) /gene="yeeD" /locus_tag="BSU_06790" /old_locus_tag="BSU06790" /label="yeeD gene" CDS complement(670858..671064) /gene="yezA" /locus_tag="BSU_06800" /old_locus_tag="BSU06800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="hypothetical protein; HGT island" /protein_id="NP_388562.1" /db_xref="EnsemblGenomes-Gn:BSU06800" /db_xref="EnsemblGenomes-Tr:CAB12500" /db_xref="GOA:O31505" /db_xref="InterPro:IPR000290" /db_xref="InterPro:IPR035900" /db_xref="SubtiList:BG12872" /db_xref="UniProtKB/Swiss-Prot:O31505" /translation="MDKLTKEELIFLVKELMNPTLDDEKVSEYLDLLEKNVPYPAPSD LIFWSNEDYTAEQVVKIALNYKDE*" /label="yezA CDS" gene complement(670858..671064) /gene="yezA" /locus_tag="BSU_06800" /old_locus_tag="BSU06800" /label="yezA gene" CDS complement(671304..671759) /gene="yezG" /locus_tag="BSU_06811" /old_locus_tag="BSU06811" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="YP_003097692.1" /db_xref="EnsemblGenomes-Gn:BSU06811" /db_xref="EnsemblGenomes-Tr:CAX52579" /db_xref="InterPro:IPR006728" /db_xref="InterPro:IPR036170" /db_xref="UniProtKB/Swiss-Prot:C0H3X4" /translation="MQDLYQLIGEKLNDIIPGEWTKIYLYAEVLDDSTMVLFHFRTPE NNQIIYSQDIPSHYNVSKDIFKTLLRELRELFEELRTEHRNNNDDVWTNLTLTLDRSG EFQLDYNYDDILASELDGYERIAIWEYKNLGILPEDEDDKEFVISYLGL*" /label="yezG CDS" gene complement(671304..671759) /gene="yezG" /locus_tag="BSU_06811" /old_locus_tag="BSU06811" /label="yezG gene" downshifts complement(671317) /Source="Nicolas_upshifts" /id="D335" /incds=0 /nref=41 /ntot=213 /MaxReadThrough="4.42275" /MaxDrop="5.23695" /score="10.2582155" /energy="-11.7" /TU="U520,U521" /idTUdmin="U520" /TUdmin="-529" /isTUend="FALSE" /label="downshifts" CDS complement(671779..673788) /gene="yeeF" /locus_tag="BSU_06812" /old_locus_tag="BSU06812" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein; HGT island" /protein_id="NP_388563.2" /db_xref="EnsemblGenomes-Gn:BSU06812" /db_xref="EnsemblGenomes-Tr:CAB12501" /db_xref="GOA:O31506" /db_xref="InterPro:IPR006829" /db_xref="SubtiList:BG12822" /db_xref="UniProtKB/Swiss-Prot:O31506" /translation="MKVFEAKTLLSEATDRAKEYKELRTQMVNLRKALKGVADLSDSE FSGKGASNIKAFYHDHVGVADQWIDYIDMKIAFFNSIAGAAEDKGLSDAYIEESFLEH ELANANKKSKSIMSEQKKAMKDILNDIDDILPLDLFSTETFKDELADANDKRKKTLEK LDALDEDLKTEYALSEPNEQFIKSDFQKLQEATGKGKNATPIHYNAKAYRESDIHKKK GDIEKRTEAYLKIKKEEAKEREIEKLKERLKNYDYADADEFYEMAKTIGYENLTAEQQ RYFTQIENTRELEAGFKGVAVGLYDSGKDAVVGLWDMVTDPGGTVEAITGAMAHPIKT YEAISAAIEESYQKDMVNGDTYSRARWVSYAVGTVVTSIVGTKGVGAVSKTGTAAKVT TKVKTAASKSATAQKAITVSKQTVDHIKQKVNTGIEVSKKHVKTKLNQIGDLTLADIL PYHPRHDLVPAGVPYNAVNGVTLKEGLQKFAKVILPKPYGTSSSGRRTPAPHVPPVTV KYGEHFARWSRKKVLKPNIIYKTKEGYTYTTDNYGRITSVKADLQLGEAKRNQYAQTN AGKPQDRKPDDDGGHLIATQFKGSGQFDNIVPMNSQINRSGGKWYEMEQEWAKALSKK PPKKVAVQIEPVYSGDSLRPSYFDVTYKIGSRKEISVSIKNQPGG*" /label="yeeF CDS" gene complement(671779..673788) /gene="yeeF" /locus_tag="BSU_06812" /old_locus_tag="BSU06812" /label="yeeF gene" promotor_-10 complement(672146..672165) /Source="Nicolas_upshift_promotors" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(672153) /Source="Nicolas_upshifts" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(672178..672183) /Source="Nicolas_upshift_promotors" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(673815..673834) /Source="Nicolas_upshift_promotors" /id="U521" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig="0.994005994005994" /xcortree=2985 /SigmaFactorBS="atgactcatttttccaccaaaacacgttctcacccccacctt atcccgaccCGTGGTAAAATTTTGATATTgagcgaacaaaagaagggaaatggtcatg a" /listShort="yeeF, yezG, yezA, yeeD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(673825) /Source="Nicolas_upshifts" /id="U521" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig="0.994005994005994" /xcortree=2985 /SigmaFactorBS="atgactcatttttccaccaaaacacgttctcacccccacctt atcccgaccCGTGGTAAAATTTTGATATTgagcgaacaaaagaagggaaatggtcatg a" /listShort="yeeF, yezG, yezA, yeeD" /GFF_Attribute="listLong" /label="upshifts" CDS 674000..675022 /gene="yeeG" /locus_tag="BSU_06820" /old_locus_tag="BSU06820" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative phage receptor protein" /protein_id="NP_388564.2" /db_xref="EnsemblGenomes-Gn:BSU06820" /db_xref="EnsemblGenomes-Tr:CAB12502" /db_xref="GOA:O31507" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12823" /db_xref="UniProtKB/Swiss-Prot:O31507" /translation="MTKKRITFGLLVLMVCVILFVLYVQLRNKDSIPVQSSAIHPEED RIFFIYSNPFIKESVLLSTSTGERFNRRTFKVADVPYIQTKSYASTDLVLLAEHEPFY YTLEKDVIKEHPLSDPFAFWYEGKDVTIEAYNVDTTGNEIHINDRKTKKEYTLTLPPL VTMGASDENFIYIIQSMSIYVIDRKTEEMIETLSLASYADQFADSEEFIVASSDHKLT VIEKGTWKTTYIAYPEDLEYADTVYYDKESGSFYVAYEDKEGGANLLEYGEDFSIHTY SLKFPYMEAKFKGNLLYIVAQEEHKKGIGGYVGVFDIHSKEMLYQFDLPEEQVKVQDF VVVDNK*" /label="yeeG CDS" gene 674000..675022 /gene="yeeG" /locus_tag="BSU_06820" /old_locus_tag="BSU06820" /label="yeeG gene" promotor_-35 675122..675129 /Source="Nicolas_upshift_promotors" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" /label="promotor_-35" promotor_-10 675143..675162 /Source="Nicolas_upshift_promotors" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" /label="promotor_-10" upshifts 675144 /Source="Nicolas_upshifts" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" /label="upshifts" CDS 675184..676314 /gene="rapH" /locus_tag="BSU_06830" /old_locus_tag="BSU06830" /EC_number="3.1.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16553878, 21908671" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 21908671; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_388565.2" /db_xref="EnsemblGenomes-Gn:BSU06830" /db_xref="EnsemblGenomes-Tr:CAB12503" /db_xref="GOA:Q59HN8" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:3Q15" /db_xref="SubtiList:BG11031" /db_xref="UniProtKB/Swiss-Prot:Q59HN8" /translation="MSQAIPSSRVGVKINEWYKMIRQFSVPDAEILKAEVEQDIQQME EDQDLLIYYSLMCFRHQLMLDYLEPGKTYGNRPTVTELLETIETPQKKLTGLLKYYSL FFRGMYEFDQKEYVEAIGYYREAEKELPFVSDDIEKAEFHFKVAEAYYHMKQTHVSMY HILQALDIYQNHPLYSIRTIQSLFVIAGNYDDFKHYDKALPHLEAALELAMDIQNDRF IAISLLNIANSYDRSGDDQMAVEHFQKAAKVSREKVPDLLPKVLFGLSWTLCKAGQTQ KAFQFIEEGLDHITARSHKFYKELFLFLQAVYKETVDERKIHDLLSYFEKKNLHAYIE ACARSAAAVFESSCHFEQAAAFYRKVLKAQEDILKGECLYAY*" /label="rapH CDS" gene 675184..676314 /gene="rapH" /locus_tag="BSU_06830" /old_locus_tag="BSU06830" /label="rapH gene" CDS 676304..676477 /gene="phrH" /locus_tag="BSU_06839" /old_locus_tag="BSU06839" /experiment="publication(s) with functional evidences, PMID:16553878, 21908671" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 21908671; Product type r: regulator" /codon_start=1 /transl_table=11 /product="hexapeptide (TDRNTT) inhibitor of regulatory cascade" /protein_id="YP_003097693.1" /db_xref="EnsemblGenomes-Gn:BSU06839" /db_xref="EnsemblGenomes-Tr:CAX52580" /db_xref="GOA:Q59HN7" /db_xref="UniProtKB/Swiss-Prot:Q59HN7" /translation="MPIKKKVMMCLAVTLVFGSMSFPTLTNSGGFKESTDRNTTYIDH SPYKLSDQKKALS*" /label="phrH CDS" gene 676304..676477 /gene="phrH" /locus_tag="BSU_06839" /old_locus_tag="BSU06839" /label="phrH gene" downshifts 676432 /Source="Nicolas_upshifts" /id="D336" /incds=0 /nref=3 /ntot=66 /MaxReadThrough="5.5891" /MaxDrop="2.9063" /score="14.5772672" /energy="-7.6" /TU="U522" /idTUdmin="U522" /TUdmin="-901" /isTUend="FALSE" /label="downshifts" S_feature 676478..676582 /Source="Nicolas_S_feature" /locus_tag="new_752253_752357" /HighExp="S2, G/S, T2.30H, GM 150, T3.0H, T2.0H, S1, T-4.40H, T-2.40H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S245" promotor_-35 676549..676556 /Source="Nicolas_upshift_promotors" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 676571..676590 /Source="Nicolas_upshift_promotors" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 676584 /Source="Nicolas_upshifts" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" /label="upshifts" CDS 676637..677356 /gene="yeeI" /locus_tag="BSU_06840" /old_locus_tag="BSU06840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA integrase or transcriptional regulator" /protein_id="NP_388566.3" /db_xref="EnsemblGenomes-Gn:BSU06840" /db_xref="EnsemblGenomes-Tr:CAB12504" /db_xref="GOA:O31509" /db_xref="InterPro:IPR002876" /db_xref="InterPro:IPR017856" /db_xref="InterPro:IPR026562" /db_xref="InterPro:IPR026564" /db_xref="InterPro:IPR029072" /db_xref="SubtiList:BG12824" /db_xref="UniProtKB/Swiss-Prot:O31509" /translation="MGRKWNNIKEKKASKDANTSRIYAKFGREIYVAAKQGEPDPESN QALKVVLERAKTYSVPKNIIERAIEKAKGGAEENYDELRYEGFGPNGSMIIVDALTNN VNRTAPEVRAAFGKNGGNMGVSGSVAYMFDATAVIGVEGKTADEALEILMEADVDVRD ILEEDDSAIVYAEPDQFHAVQEAFKNAGVEEFTVAELTMLAQSEVTLPDDAKEQFEKL IDALEDLEDVQQVYHNVDLGE*" /label="yeeI CDS" gene 676637..677356 /gene="yeeI" /locus_tag="BSU_06840" /old_locus_tag="BSU06840" /label="yeeI gene" downshifts complement(676639) /Source="Nicolas_upshifts" /id="D337" /incds=0 /nref=3 /ntot=70 /MaxReadThrough="1.42969" /MaxDrop="3.99424" /score="-5.23712559" /energy="-7.6" /TU="NA" /idTUdmin="U520" /TUdmin="-5851" /isTUend="FALSE" /label="downshifts" promotor_-35 677214..677221 /Source="Nicolas_upshift_promotors" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 677235..677254 /Source="Nicolas_upshift_promotors" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 677245 /Source="Nicolas_upshifts" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" /label="upshifts" downshifts 677338 /Source="Nicolas_upshifts" /id="D338" /incds=0 /nref=223 /ntot=271 /MaxReadThrough="4.94236" /MaxDrop="5.19148" /score="31.0415099" /energy="-11.4" /TU="U523,U524" /idTUdmin="U522" /TUdmin=5 /isTUend="TRUE" /label="downshifts" promotor_-35 677425..677434 /Source="Nicolas_upshift_promotors" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 677448..677467 /Source="Nicolas_upshift_promotors" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 677451 /Source="Nicolas_upshifts" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(677455..677473) /Source="Nicolas_upshift_promotors" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(677475) /Source="Nicolas_upshifts" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(677489..677494) /Source="Nicolas_upshift_promotors" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 677490..677927 /gene="cotK" /locus_tag="BSU_06850" /old_locus_tag="BSU06850" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10714992, 19060142, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10714992, 19060142, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore inner coat protein" /protein_id="NP_388567.2" /db_xref="EnsemblGenomes-Gn:BSU06850" /db_xref="EnsemblGenomes-Tr:CAB12505" /db_xref="GOA:O31510" /db_xref="SubtiList:BG12825" /db_xref="UniProtKB/Swiss-Prot:O31510" /translation="MTDTRHMYGGPGFGHYQGFGIGHPGYGMQSTGYPGYGMYGGHPG YGMQGYPDHGIHGGVGGYPGYGGYGGYPSGGYGGSPGTGSYPSMHHENDGHHHYYHHH HDGKDNLHHHHHHVGKDNHHHHHDGHYGHHHHHMGHWGKDGYK*" /label="cotK CDS" gene 677490..677927 /gene="cotK" /locus_tag="BSU_06850" /old_locus_tag="BSU06850" /label="cotK gene" downshifts complement(677497) /Source="Nicolas_upshifts" /id="D339" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.62645" /MaxDrop="3.26146" /score="-5.23712559" /energy="-7.6" /TU="NA" /idTUdmin="U520" /TUdmin="-6709" /isTUend="FALSE" /label="downshifts" downshifts 677927 /Source="Nicolas_upshifts" /id="D340" /incds=0 /nref=82 /ntot=208 /MaxReadThrough="2.37564" /MaxDrop="8.21113" /score="17.7046271" /energy="-9" /TU="U525" /idTUdmin="U523" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 677987..677994 /Source="Nicolas_upshift_promotors" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 678010..678029 /Source="Nicolas_upshift_promotors" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 678015 /Source="Nicolas_upshifts" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" /label="upshifts" CDS 678042..678626 /gene="yezE" /locus_tag="BSU_06860" /old_locus_tag="BSU06860" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR family)" /protein_id="YP_054572.1" /db_xref="EnsemblGenomes-Gn:BSU06860" /db_xref="EnsemblGenomes-Tr:CAE01448" /db_xref="GOA:Q7WY76" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG14194" /db_xref="UniProtKB/Swiss-Prot:Q7WY76" /translation="MGRNKEFDTALVLHRAIEVFGEYGYEGTSLQDLLSHLGIARQSL YDTYGTKRDLFLSAVKSYLEGKNAAVMERLEAPGSVKEAIRDIFQEGVNALRDPERAK ACYIINSAIEQIPHDPELARYFERQSKQLEDAFYHGLLRAKDQGELNGEDTDISALAR YLNQSRLSLTFIAKVTADMDRLQDHVDVSLSVLD*" /label="yezE CDS" gene 678042..678626 /gene="yezE" /locus_tag="BSU_06860" /old_locus_tag="BSU06860" /label="yezE gene" downshifts 678607 /Source="Nicolas_upshifts" /id="D341" /incds=0 /nref=26 /ntot=216 /MaxReadThrough="2.43615" /MaxDrop="3.31193" /score="17.7046271" /energy="-9" /TU="NA" /idTUdmin="U527" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS 678705..679148 /gene="yesE" /locus_tag="BSU_06870" /old_locus_tag="BSU06870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388568.1" /db_xref="EnsemblGenomes-Gn:BSU06870" /db_xref="EnsemblGenomes-Tr:CAB12506" /db_xref="InterPro:IPR009959" /db_xref="InterPro:IPR032710" /db_xref="PDB:1S5A" /db_xref="SubtiList:BG12844" /db_xref="UniProtKB/Swiss-Prot:O31511" /translation="MLMNEFEKACETLRKFMAYMLEKDMKSWTELWDENAVFEFPYAP EGSPKRIEGKAAIYDYIKDYPKQIHLSSFTAPTVYRSADSNTVIAEFQCDGHVIETGL PYRQSYISVIETRDGRIVRYRDYWNPLVVKEAFGGSFLQTEESGK*" /label="yesE CDS" gene 678705..679148 /gene="yesE" /locus_tag="BSU_06870" /old_locus_tag="BSU06870" /label="yesE gene" CDS 679145..680005 /gene="yesF" /locus_tag="BSU_06880" /old_locus_tag="BSU06880" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21494745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388569.1" /db_xref="EnsemblGenomes-Gn:BSU06880" /db_xref="EnsemblGenomes-Tr:CAB12507" /db_xref="GOA:O31512" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR008030" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11808" /db_xref="UniProtKB/Swiss-Prot:O31512" /translation="MMKQNPILITGGTGTVGSRIASRLIKLGYRVRIASRKKGALADA EYVYFNWKYASSFTPALEQVKQIYLVAPVGVFDPAPYVLPFLKEAKRLGAKRVVMQSA SVVSENGPVFGALHQAVREFPEWTVLRPSYFMQNFINVQHRMSIQTEGRITTASGEGK LGFIDADDIAETAVRALIDDVPHQTHHILTGPEALSYAEAAEIIGAAAGRRVEHVSIS RSELQHKMEAGGLPADYAHFMAKLDEAISHGAEHRVTDTVKRVTGKEPRSLSEFAAAH AAYWTSFWTE*" /label="yesF CDS" gene 679145..680005 /gene="yesF" /locus_tag="BSU_06880" /old_locus_tag="BSU06880" /label="yesF gene" promotor_-35 680067..680072 /Source="Nicolas_upshift_promotors" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 680088..680106 /Source="Nicolas_upshift_promotors" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 680088 /Source="Nicolas_upshifts" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(680110..680124) /Source="Nicolas_upshift_promotors" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(680115) /Source="Nicolas_upshifts" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(680132..680136) /Source="Nicolas_upshift_promotors" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 680132..680380 /gene="cotJA" /locus_tag="BSU_06890" /old_locus_tag="BSU06890" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the inner spore coat" /protein_id="NP_388570.1" /db_xref="EnsemblGenomes-Gn:BSU06890" /db_xref="EnsemblGenomes-Tr:CAB12508" /db_xref="InterPro:IPR020256" /db_xref="SubtiList:BG11799" /db_xref="UniProtKB/Swiss-Prot:Q45536" /translation="MKDMQPFTPVKSYTPFHSRFDPCPPIGKKYYRTPPNLYMTFQPE HMEQFSPMEALRKGTLWKDLYDFYENPYRGGDAHGKKG*" /label="cotJA CDS" gene 680132..680380 /gene="cotJA" /locus_tag="BSU_06890" /old_locus_tag="BSU06890" /label="cotJA gene" CDS 680364..680627 /gene="cotJB" /locus_tag="BSU_06900" /old_locus_tag="BSU06900" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the inner spore coat" /protein_id="NP_388571.2" /db_xref="EnsemblGenomes-Gn:BSU06900" /db_xref="EnsemblGenomes-Tr:CAB12509" /db_xref="InterPro:IPR016571" /db_xref="InterPro:IPR024207" /db_xref="SubtiList:BG11800" /db_xref="UniProtKB/Swiss-Prot:Q45537" /translation="MAKKVDAEYYRQLEQIQAADFVLVELSLYLNTHPHDEDALKQFN QYSGYSRHLKRQFESSYGPLLQFGNSPAGKDWDWGKGPWPWQV*" /label="cotJB CDS" gene 680364..680627 /gene="cotJB" /locus_tag="BSU_06900" /old_locus_tag="BSU06900" /label="cotJB gene" CDS 680642..681211 /gene="cotJC" /locus_tag="BSU_06910" /old_locus_tag="BSU06910" /EC_number="1.11.1.6" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7768848, 9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7768848, 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="enzyme component of the inner spore coat" /protein_id="NP_388572.1" /db_xref="EnsemblGenomes-Gn:BSU06910" /db_xref="EnsemblGenomes-Tr:CAB12510" /db_xref="InterPro:IPR007760" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG11801" /db_xref="UniProtKB/Swiss-Prot:Q45538" /translation="MWVYEKKLQYPVKVSTCNPTLAKYLIEQYGGADGELAAALRYLN QRYTIPDKVIGLLTDIGTEEFAHLEMIATMVYKLTKDATPEQLREAGLGDHYVNHDSA LFYHNAAGVPFTASYIQAKGDPIADLYEDIAAEEKARATYQWLIDISDDPDLNDSLRF LREREIVHSMRFREAVEILKEERDKKKIF*" /label="cotJC CDS" gene 680642..681211 /gene="cotJC" /locus_tag="BSU_06910" /old_locus_tag="BSU06910" /label="cotJC gene" S_feature 681212..681290 /Source="Nicolas_S_feature" /locus_tag="new_756987_757065" /HighExp="S4, S5, S3, S7, S6, B36, LoTm, BT, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S246" promotor_-35 681263..681268 /Source="Nicolas_upshift_promotors" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 681283..681302 /Source="Nicolas_upshift_promotors" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 681292 /Source="Nicolas_upshifts" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" /label="upshifts" CDS 681336..681878 /gene="yesJ" /locus_tag="BSU_06920" /old_locus_tag="BSU06920" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388573.1" /db_xref="EnsemblGenomes-Gn:BSU06920" /db_xref="EnsemblGenomes-Tr:CAB12511" /db_xref="GOA:O31513" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11809" /db_xref="UniProtKB/Swiss-Prot:O31513" /translation="MTAFKIENETIADGFYACPAVYEDAESITGLLVRTAEWLRDRGS NQWSGLLKGQDIHDITGSIEKGHVFVFKKDEELAAVVMLLPAPSEWDRTLWGDDGHEE SIYLHRLAVSRRFAGQGLGARVLQWAETGIHFPEKTRIRLDCVADSDALHSFYRRMGY EFMGADASGYHLFEKEITAE*" /label="yesJ CDS" gene 681336..681878 /gene="yesJ" /locus_tag="BSU_06920" /old_locus_tag="BSU06920" /label="yesJ gene" downshifts 681845 /Source="Nicolas_upshifts" /id="D342" /incds=0 /nref=104 /ntot=251 /MaxReadThrough="3.04389" /MaxDrop="4.5316" /score="8.56782582" /energy="-5.8" /TU="U528" /idTUdmin="U530" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS 681901..682203 /gene="yesK" /locus_tag="BSU_06930" /old_locus_tag="BSU06930" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane component" /protein_id="NP_388574.2" /db_xref="EnsemblGenomes-Gn:BSU06930" /db_xref="EnsemblGenomes-Tr:CAB12512" /db_xref="GOA:O31514" /db_xref="InterPro:IPR025434" /db_xref="SubtiList:BG12845" /db_xref="UniProtKB/Swiss-Prot:O31514" /translation="MSFSKREAGDVWSILFVTGIVTACLFAGVSVLMRMRFPDKSRPE WMLAGLIVLGVFAIWYSLVYVRGWEGAALGMLGFNVIFGAIAGYLIDKAIRRYRKR*" /label="yesK CDS" gene 681901..682203 /gene="yesK" /locus_tag="BSU_06930" /old_locus_tag="BSU06930" /label="yesK gene" promotor_-35 682246..682254 /Source="Nicolas_upshift_promotors" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 682265..682283 /Source="Nicolas_upshift_promotors" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 682271 /Source="Nicolas_upshifts" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" /label="upshifts" CDS 682318..682947 /gene="yesL" /locus_tag="BSU_06940" /old_locus_tag="BSU06940" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25441682; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease or sensor of a three componentsystem for pectin and rhamnogalacturonan transport anddegradation" /protein_id="NP_388575.1" /db_xref="EnsemblGenomes-Gn:BSU06940" /db_xref="EnsemblGenomes-Tr:CAB12513" /db_xref="GOA:O31515" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG12846" /db_xref="UniProtKB/Swiss-Prot:O31515" /translation="MLMIHSVANGLNHFCTWVMRLAYLNVLWILFSLAGLVVFGLMPA TAAMFTVAREWAKGNTDAPVFSVFFRTFKKEWRASQILGLIVVTAALFLFADMRIAAQ MDQPVLVNVFVSISLIFAFVVLYVFPVFSHFDVKIREVLSISFFIAFSRPAVTLLMAA GAVGVLCLVLFHVTFLLFFSGSLLSLILTKLSFKAFRSMDQRQEKEKAA*" /label="yesL CDS" gene 682318..682947 /gene="yesL" /locus_tag="BSU_06940" /old_locus_tag="BSU06940" /label="yesL gene" CDS 682944..684677 /gene="yesM" /locus_tag="BSU_06950" /old_locus_tag="BSU06950" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 23436677, 25441682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 23436677, 25441682; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YesN]" /protein_id="NP_388576.1" /db_xref="EnsemblGenomes-Gn:BSU06950" /db_xref="EnsemblGenomes-Tr:CAB12514" /db_xref="GOA:O31516" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR033479" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12847" /db_xref="UniProtKB/Swiss-Prot:O31516" /translation="MKKRVAGWYRRMKIKDKLFVFLSLIMAVSFLFVYSGVQYAFHVY DEQIYRKSSEVLRMSSERIEDELKKIEDVSYEIITDEQIQRILSMQNRDDTYDQYQMK QELWDQLAGYASDEKYIDSIHVIDARGSEYSAGSSSSDLLQQEQEEVFKRAKAKSGRN LWMTLGGSDPVLISARQIRSYHQLSLNGLGMVLIQVNVKQMIRDVPKDWGDSVGDIMI ADQGGNLVYTAHASAHVPEAAKETLKHPGYDLIKKNGKRYFISYLQSSYQNWSYYNVI PFDQMFAKISFMKTVIGTCFLLFFCVVLLFGRKIANSITEPIEQLVTAMKSVQHSGIE AGVSLSLPEHTQDEAGMLNRHFTVMMKRINELMEENVEKQLIIKETELKALQAQINPH FLYNTLESINWLAKANQQKQISKMVESLGFLLRNSIHMKKDIVTIQEEADIVRHYMTI QRFRFEERLKFTLDIDDEVKHCLIPKLTLQPLAENAIQYALEPFTRPCAIRIQAKKAK GCVCITVEDNGPGMDGRILESTGGRGIGLWNIRERISLTFGEPYGLRIHSEHEKGTRI VITIPCRNEVV*" /label="yesM CDS" gene 682944..684677 /gene="yesM" /locus_tag="BSU_06950" /old_locus_tag="BSU06950" /label="yesM gene" CDS 684677..685783 /gene="yesN" /locus_tag="BSU_06960" /old_locus_tag="BSU06960" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:25441682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25441682; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YesM]" /protein_id="NP_388577.1" /db_xref="EnsemblGenomes-Gn:BSU06960" /db_xref="EnsemblGenomes-Tr:CAB12515" /db_xref="GOA:O31517" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12848" /db_xref="UniProtKB/Swiss-Prot:O31517" /translation="MYKILLADDERIILDGMAGIIEWESLGASLIGKAQNGHEAYEKI VHKQPHIVITDVKMPGMDGLELIKKVSAVSPSVQFIVLSGFGEFEYAKEAMKYGVKHY LLKPCNEQQIISSLEEIIAELKRQDVHKKKTAHLKHELDHIRSFAADQYLEGLIAGVA QLSPPPSLAGKKIRLLILKGEQSIDAAAREALGSALTAVCSSGEWTVLAVEENAAEKV AEVFADRKMAISQAGELRHAGQLFRDTAEASGDLHGSAVISKMIRLIADELGNPNLSL KWAAKDMLFMNPDYLGKLFKQETGEKFSQYVTRVRLEHAMKQMKIRRDVSVSEIAEEI GFGDNPKYFSLVFKKYTGLTPSEFRRKQGGASAG*" /label="yesN CDS" gene 684677..685783 /gene="yesN" /locus_tag="BSU_06960" /old_locus_tag="BSU06960" /label="yesN gene" downshifts 685737 /Source="Nicolas_upshifts" /id="D343" /incds=0 /nref=4 /ntot=43 /MaxReadThrough="0.271749999999999" /MaxDrop="3.41261" /score="3.12085441" /energy="-10.3" /TU="NA" /idTUdmin="U531" /TUdmin=1408 /isTUend="FALSE" /label="downshifts" promotor_-35 685822..685825 /Source="Nicolas_upshift_promotors" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 685840..685859 /Source="Nicolas_upshift_promotors" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 685847 /Source="Nicolas_upshifts" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 685887..687170 /gene="yesO" /locus_tag="BSU_06970" /old_locus_tag="BSU06970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 25658435" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 25658435; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="pectin degradation byproducts (rhamnose oligosaccharides)-binding lipoprotein" /protein_id="NP_388578.2" /db_xref="EnsemblGenomes-Gn:BSU06970" /db_xref="EnsemblGenomes-Tr:CAB12516" /db_xref="PDB:4R6K" /db_xref="SubtiList:BG12849" /db_xref="UniProtKB/Swiss-Prot:O31518" /translation="MKKICYVLLSLVCVFLFSGCSAGEEASGKKEDVTLRIAWWGGQP RHDYTTKVIELYEKKNPHVHIEAEFANWDDYWKKLAPMSAAGQLPDVIQMDTAYLAQY GKKNQLEDLTPYTKDGTIDVSSIDENMLSGGKIDNKLYGFTLGVNVLSVIANEDLLKK AGVSINQENWTWEDYEKLAYDLQEKAGVYGSNGMHPPDIFFPYYLRTKGERFYKEDGT GLAYQDDQLFVDYFERQLRLVKAKTSPTPDESAQIKGMEDDFIVKGKSAITWNYSNQY LGFARLTDSPLSLYLPPEQMQEKALTLKPSMLFSIPKSSEHKKEAAKFINFFVNNEEA NQLIKGERGVPVSDKVADAIKPKLNEEETNIVEYVETASKNISKADPPEPVGSAEVIK LLKDTSDQILYQKVSPEKAAKTFRKKANEILERNN*" /label="yesO CDS" gene 685887..687170 /gene="yesO" /locus_tag="BSU_06970" /old_locus_tag="BSU06970" /label="yesO gene" CDS 687167..688096 /gene="rhgP" /locus_tag="BSU_06980" /old_locus_tag="BSU06980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691; Product type t: transporter" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan permease" /protein_id="NP_388579.1" /db_xref="EnsemblGenomes-Gn:BSU06980" /db_xref="EnsemblGenomes-Tr:CAB12517" /db_xref="GOA:O31519" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12850" /db_xref="UniProtKB/Swiss-Prot:O31519" /translation="MTGNGADAMKKSRSIRKDNLAGYAFISPFIIGFLCFTVIPMGAS LFLSFTSYDLFTAPKWIGLDNFKEMFTGDEKYWQSLKVTFTYVLAGVPLRLGFALFIA VILNNAAKGTAIYRTLFYLPSIIGGSVAVAIMWRNIFGNDGVINALLFFVGIDQKILW YQNPTSALWTLILLSVWQFGSSMLIFLAGLKNIPSSYLEAASVDGANRVQRFFKITLP ILTPIIFFNLVMQTISAFMTFTPAYIISKGEGGPLDGTLLYSLYLFQRAFNYFQMGYA SAMAWVMLVIVGLITLILFKTSSYWVHYESKEE*" /label="rhgP CDS" gene 687167..688096 /gene="rhgP" /locus_tag="BSU_06980" /old_locus_tag="BSU06980" /label="rhgP gene" CDS 688100..688990 /gene="rhgQ" /locus_tag="BSU_06990" /old_locus_tag="BSU06990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691; Product type t: transporter" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan permease" /protein_id="NP_388580.1" /db_xref="EnsemblGenomes-Gn:BSU06990" /db_xref="EnsemblGenomes-Tr:CAB12518" /db_xref="GOA:O31520" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12851" /db_xref="UniProtKB/Swiss-Prot:O31520" /translation="MEPVNQPVREAPVFERKKAGRVSPKRILFHVFTATLAVLLLYPV IWLFVSSFKESASIFTTSHSLIPDPFILSNYAEGWKGIAGQPFLTFIKNSAIIVGLST IGAVMSSAVIAYGFARIPFKGKKFWFACMMGTLMLPHEVLMIPQYIMFAKLDWLNSFK PIVVPQFFGHAFFIFLMIQFIRTIPEELDEAARIDGCGRFACFWRIILPLIAPALATS AIFSFYWKWEELIQPLLYLNKPELYPVSLALKLFLDTESASNWGAMFAMSAVSLLPVI LVFFLFQKYIVQGISTTGLK*" /label="rhgQ CDS" gene 688100..688990 /gene="rhgQ" /locus_tag="BSU_06990" /old_locus_tag="BSU06990" /label="rhgQ gene" CDS 689006..690040 /gene="rhgH" /locus_tag="BSU_07000" /old_locus_tag="BSU07000" /EC_number="3.2.1.172" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan hydrolase" /protein_id="NP_388581.1" /db_xref="EnsemblGenomes-Gn:BSU07000" /db_xref="EnsemblGenomes-Tr:CAB12519" /db_xref="GOA:O31521" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR010905" /db_xref="SubtiList:BG12852" /db_xref="UniProtKB/Swiss-Prot:O31521" /translation="MAQLIFDEEKVTSVIDRIVKRTFQMDFAWDWPGGVAFYGVAEAY EATENEEYINLLKTWVDEQLEDGLPPLSINGVSIGHTLLFLHKVTGDDVYLETAAEMA EYVLHKAPRFGEGILQHTVNAAEYVFPEQAWADTLMMAGLFMLRIGRVMEREDYFEDG LRQFHGHEDVLQDPVTNLYYHAWDNKAQNHLSGIYWGRANGWAALTMAKALPLIEVTH PSFMIIDGSLRDQLSALVRLQDESGLWHTILDDPDSYLEVSASAGIASALMSSGKLYT KYVQKSLAAILDAVEEDGRVSRVSAGTAVMKNAEGYKQVPYKRIQGWGQGLALTFLAD VLKTKKRLYQ*" /label="rhgH CDS" gene 689006..690040 /gene="rhgH" /locus_tag="BSU_07000" /old_locus_tag="BSU07000" /label="rhgH gene" CDS 690063..692348 /gene="rhgR" /locus_tag="BSU_07010" /old_locus_tag="BSU07010" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19651770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19651770; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AraC/XylS family)" /protein_id="NP_388582.1" /db_xref="EnsemblGenomes-Gn:BSU07010" /db_xref="EnsemblGenomes-Tr:CAB12520" /db_xref="GOA:O31522" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG12853" /db_xref="UniProtKB/Swiss-Prot:O31522" /translation="MKKQPQQKERVSRWKGTYFKRNFVFILLIACIPGLLTGGAIYFL SIDKVEKELQRSHETQVAREVSRMDEKLGVLELALTQMAYDSSLMNGLAERDLEKDFT FSYQLTKKLFLLRDQQPLIEQASIFLNSPRPLVLSPEYSALTEQEALRKYRSLLASDH SIYWKRSGNQAMLIQLIPGAAEKPFGAIMLAVDPKEMESILQSLSPYPDGSALLLDQN REVLFHEGEKDFEKTLLHEIKKQPAENGHFQMEWKGKVYSVSFGEMNRMHQQWTFVSA APLSAITAPMVFLSKVIIVMLVICIGLAVCMTWYASKKIYRPIQHLLGLFTGGEKKTW QASGQDEFKWIEKRWQDLSLESRKLQQQLLRQTPHMKKSFLQHLLQSDFYYDNEESLR FRMEEAGWNIGGNVFHVLDLQVTGLRCEKSIFREGDEQLAVFTLTNIAEELAAKRVFQ LSILDIGRLSVTVLVMKTNSSDLKAYITELARQFGDVTGLCLTSTLSSKTERVTEIPS LFQDVKCGKSRRKFANRDQVIDLQADFPRDEQFAPYYPFELEKQIVQTIRLERKQEAK ELIDGCMKELSEKAAIDRHVHSALIQLFSRIQEDILHSGLNPSELFQHRNPFLDISEL REPNEAAAWLMDVVVTPYLSKLEGRKNRQQKQLAERVIAMIHEQYMADISLESCADAL GMNSYTLSKAFKQVTGINFIDYVTQIRIEKAKELLVNTNKKIHDVSEEVGYRHNYFNR IFKKQVGMPPGVFRQMYQETP*" /label="rhgR CDS" gene 690063..692348 /gene="rhgR" /locus_tag="BSU_07010" /old_locus_tag="BSU07010" /label="rhgR gene" CDS 692362..693060 /gene="rhgT" /locus_tag="BSU_07020" /old_locus_tag="BSU07020" /EC_number="3.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 17957779" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 17957779; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan acetylesterase" /protein_id="NP_388583.1" /db_xref="EnsemblGenomes-Gn:BSU07020" /db_xref="EnsemblGenomes-Tr:CAB12521" /db_xref="GOA:O31523" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12854" /db_xref="UniProtKB/Swiss-Prot:O31523" /translation="MMKKPIQVFLAGDSTVSDCPPHEAPMAGWGQVFGQLFSEGVLVR NHAKGGASTNSFVEEGRLQAIAEHITQGDYLLIQFGHNDQKPRGTKPYSTFQQFLTLF ADTAREKGAHPVFVTSVQRRRFDENGRIEHTLGEYPDAMKALAKELDVPVIDLLAKTK VLYEAYGPEESKRLFVWFQPNEHPNYPDGIEDNTHFSEKGAMEVAKLVAEGIEELGLP LKDHLVSREGKEHV*" /label="rhgT CDS" gene 692362..693060 /gene="rhgT" /locus_tag="BSU_07020" /old_locus_tag="BSU07020" /label="rhgT gene" CDS 693053..693715 /gene="yesU" /locus_tag="BSU_07030" /old_locus_tag="BSU07030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388584.1" /db_xref="EnsemblGenomes-Gn:BSU07030" /db_xref="EnsemblGenomes-Tr:CAB12522" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR015305" /db_xref="PDB:1OQ1" /db_xref="SubtiList:BG12855" /db_xref="UniProtKB/Swiss-Prot:O31524" /translation="MYKEGACLYRNPLRSKSDVKDWRMEGGGQISFDDHSLHLSHVQD EAHFVFWCPETFPDGIIVTWDFSPIEQPGLCMLFFAAAGIRGEDLFDPSLRKRTGTYP EYHSGDINALHLSYFRRKYAEERAFRTCNLRKSRGFHLAAMGADPLPSPDDADSPYRM KLIKDKGYVHFSINGLPILEWMDDGSTYGPVLTKGKIGFRQMAPMKAVYRDFAVHQAV RR*" /label="yesU CDS" gene 693053..693715 /gene="yesU" /locus_tag="BSU_07030" /old_locus_tag="BSU07030" /label="yesU gene" CDS 693712..694338 /gene="yesV" /locus_tag="BSU_07040" /old_locus_tag="BSU07040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17449691; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane component" /protein_id="NP_388585.1" /db_xref="EnsemblGenomes-Gn:BSU07040" /db_xref="EnsemblGenomes-Tr:CAB12523" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG12856" /db_xref="UniProtKB/Swiss-Prot:O31525" /translation="MKTTVTDALYAGCEAVVKIAWLNGLWLLFTLLGGVLFGWAPSTA AMCAVIRKWLMGQKDVPIFSLFLDTYKKEFLKVNAIGLAFSALLLILSANYHYFSAST NWLSFAVTSCTLLAGLLYIIALMYVFPLYVHYQLPLRKYIPQALLFGAMRPLTTGCML IGCGFVLYLLYTLPGLIPFYGPCLFGLVLMFFALRGFQKTEAQHHQAG*" /label="yesV CDS" gene 693712..694338 /gene="yesV" /locus_tag="BSU_07040" /old_locus_tag="BSU07040" /label="yesV gene" CDS 694459..696321 /gene="rhgW" /locus_tag="BSU_07050" /old_locus_tag="BSU07050" /EC_number="4.2.2.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19193638" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19193638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan endolyase" /protein_id="NP_388586.1" /db_xref="EnsemblGenomes-Gn:BSU07050" /db_xref="EnsemblGenomes-Tr:CAB12524" /db_xref="GOA:O31526" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR034641" /db_xref="PDB:2Z8R" /db_xref="PDB:2Z8S" /db_xref="PDB:2ZUX" /db_xref="SubtiList:BG12857" /db_xref="UniProtKB/Swiss-Prot:O31526" /translation="MRRSCLMIRRRKRMFTAVTLLVLLVMGTSVCPVKAEGAARQMEA LNRGLVAVKTDGGIFVSWRFLGTENASVLFNVYRDGQKLNAAPVKTTNYVDKNGSAGS TYTVRAVVNGTEQPASEKASVWAQPYHSVPLDKPAGGTTPKGESYTYSANDASVGDVD GDGQYELILKWDPSNSKDNSQDGYTGDVLIDAYKLDGTKLWRINLGKNIRAGAHYTQF MVYDLDGDGKAEVAMKTADGTKDGTGKVIGNANADYRNEQGRVLSGPEYLTVFQGSTG KELVTANFEPARGNVSDWGDSYGNRVDRFLAGIAYLDGQRPSLIMTRGYYAKTMLVAY NFRDGKLSKLWTLDSSKSGNEAFAGQGNHNLSIADVDGDGKDEIIFGSMAVDHDGKGM YSTGLGHGDALHTGDLDPGRPGLEVFQVHEDKNAKYGLSFRDAATGKILWGVYAGKDV GRGMAADIDPRYPGQEVWANGSLYSAKGVKIGSGVPSSTNFGIWWDGDLLREQLDSNR IDKWDYQNGVSKNMLTASGAAANNGTKATPTLQADLLGDWREEVVWRTEDSSALRIYT TTIPTEHRLYTLMHDPVYRLGIAWQNIAYNQPPHTSFFLGDGMAEQPKPNMYTP*" /label="rhgW CDS" gene 694459..696321 /gene="rhgW" /locus_tag="BSU_07050" /old_locus_tag="BSU07050" /label="rhgW gene" promotor_no_box 694499..694599 /Source="Nicolas_upshift_promotors" /id="U533" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.000999000999001" /xcortree=1487 /SigmaFactorBS="tgtttaccgctgttacgttgctggtcttgttggtgatgggaa cctctgtatgtcctgtgaaagctgaaggggcagcgcggcagatggaagcgctgaaccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 694559 /Source="Nicolas_upshifts" /id="U533" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.000999000999001" /xcortree=1487 /SigmaFactorBS="tgtttaccgctgttacgttgctggtcttgttggtgatgggaa cctctgtatgtcctgtgaaagctgaaggggcagcgcggcagatggaagcgctgaaccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(695097) /Source="Nicolas_upshifts" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(695098..695117) /Source="Nicolas_upshift_promotors" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(695130..695139) /Source="Nicolas_upshift_promotors" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 696367..698205 /gene="rhgX" /locus_tag="BSU_07060" /old_locus_tag="BSU07060" /EC_number="4.2.2.24" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19193638" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19193638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan exolyase" /protein_id="NP_388587.1" /db_xref="EnsemblGenomes-Gn:BSU07060" /db_xref="EnsemblGenomes-Tr:CAB12525" /db_xref="GOA:O31527" /db_xref="InterPro:IPR013517" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR034641" /db_xref="PDB:2ZUY" /db_xref="SubtiList:BG12858" /db_xref="UniProtKB/Swiss-Prot:O31527" /translation="MKPKKRQMEYLTRGLIAVQTEQGVFVSWRFLGTDHETTAFHLYR DGKRITRDPIAESTNFLDQNGTADSVYQVAAVNKGREEKLSKKARVWQENVLEVPLAK PEGGVTPDGKPYTYSANDASVGDIDGDGEYEMILKWDPSNSKDNAHDGYTGEVLIDAY KLDGTFLWRINLGRNIRAGAHYTQFMVYDLDGDGKAEIAMKTADGTTDGKGHIIGDEQ ADFRNEQGRILSGPEYLTVFKGETGEALTTVEYEPPRGKLEDWGDGYGNRMDRFLAGT AYLDGERPSLVMARGYYTRTVLVAYDFRNGRLKKRWVFDSNQPGHEAYAGQGNHSLSV ADVDGDGKDEIIYGAMAVDHDGTGLYSTGLGHGDAMHVGDLDPSRKGLEVFQVHEDAT KPYGLSLRDAGTGEILWGVHAGTDVGRGMAAHIDPSYKGSLVWGIDPPGNDGMSYGLF TSKGEKISDKAPSSANFAIWWDGDLVRELLDHDWDGTIGRPKIEKWDAENGCLKTIFQ PAGVLSNNGTKGNPVLQANLFGDWREEVIWRTEDSSALRIYTTTHLTRHCFYTLMHDP VYRLGIAWQNTAYNQPPHTSFYLGTGMKKPPKPALYIAGSKAEAPL*" /label="rhgX CDS" gene 696367..698205 /gene="rhgX" /locus_tag="BSU_07060" /old_locus_tag="BSU07060" /label="rhgX gene" CDS 698363..699016 /gene="yesY" /locus_tag="BSU_07070" /old_locus_tag="BSU07070" /EC_number="3.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan acetylesterase" /protein_id="NP_388588.1" /db_xref="EnsemblGenomes-Gn:BSU07070" /db_xref="EnsemblGenomes-Tr:CAB12526" /db_xref="GOA:O31528" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12859" /db_xref="UniProtKB/Swiss-Prot:O31528" /translation="MANHIYLAGDSTVQTYGDSTNQGGWGQFLGSHLPEHIQVINRAI GGRSSKTFVEEGRLQAILDVIEPDDWLFVQMGHNDASKNKPERYTEPYTTYKQYLKQY IAGAREKGAHPLLITPVARFHYENGVFLNDFPDYCIAMKQTAAEENVQLIDLMEKSLA FFTEKGEEKVYTYFMISEGINDYTHFTKKGANEMAKLVAKGIKELGLPLTESIIKER* " /label="yesY CDS" gene 698363..699016 /gene="yesY" /locus_tag="BSU_07070" /old_locus_tag="BSU07070" /label="yesY gene" CDS 699024..701015 /gene="rhgZ" /locus_tag="BSU_07080" /old_locus_tag="BSU07080" /EC_number="3.2.1.67" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17056685, 17449691, 17485082" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17056685, 17449691, 17485082; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-galacturonidase" /protein_id="NP_388589.1" /db_xref="EnsemblGenomes-Gn:BSU07080" /db_xref="EnsemblGenomes-Tr:CAB12527" /db_xref="GOA:O31529" /db_xref="InterPro:IPR003476" /db_xref="InterPro:IPR013529" /db_xref="InterPro:IPR013738" /db_xref="InterPro:IPR013739" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12860" /db_xref="UniProtKB/Swiss-Prot:O31529" /translation="MRKLYHGACYYPELWDEETIQQDIDIMREVGVNVVRIGEFAWSV MEPEEGKIDVGFFKEIIARLYDSGIETIMCTPTPTPPIWFSHGRPERMHANEKREIMG HGSRQHACTNNPYFRKKAAIITTAIAKELGRLPGLIGWQLDNEFKCHVAECMCETCLR LWHDWLKNRYGVIERLNEAWGTDVWSETYQTFEQVPQPGPAPFLHHASLRTMYQLFSM EMIASFADEQAKIIRCYSDAPITHNGSVMFSVDNERMFQNLDFASYDTYASQENASAF LLNCDLWRNLKQGRPFWILETSPSYAASLESSAYPHADGYLQAEAVSSYALGSQGFCY WLWRQQRSGSEISHGSVLSAWGEPTIGYQNVLAVERARKEIEPIILSTEPVQAEAAMT YSDRAKAFIKTEPHRGLRHRSLVTHFYERILNTGIHRDLIPEGAPLDGYRLLFTPFVP YLSSEFIKKASAFAEAGGIWITGPLTGGRTCEHTIHTDCGLGELEKTSGIKTLFTFPM NENVNTGKAFGITAPLGLWSAVFDTESGNTLGTVEAGPGAGHAFLTERNYGEGKIVML GSLPSGKEGDAMLEALVRHYAEEAVISSRSDVTPGTIVAPRIGENGLVWIVVNMDGKG GSVTLPESGTDLLTHRLEKAGRLAVGPHEYRVIQFDNHS*" /label="rhgZ CDS" gene 699024..701015 /gene="rhgZ" /locus_tag="BSU_07080" /old_locus_tag="BSU07080" /label="rhgZ gene" CDS 701059..703632 /gene="yetA" /locus_tag="BSU_07090" /old_locus_tag="BSU07090" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388590.2" /db_xref="EnsemblGenomes-Gn:BSU07090" /db_xref="EnsemblGenomes-Tr:CAB12528" /db_xref="SubtiList:BG12861" /db_xref="UniProtKB/Swiss-Prot:O31530" /translation="MKKIKWLSGQPKVTSGVTWGMPWKKGELKKGDRLALMNENAETR YVQSEPSAYWPDGSIKWTKHAAVFGGQENQSFTVHKREVPQPTESLSILETEHDIQVD TGALVCTIHKTGSDFIQSLQINGKPIAAGGRLVAIRETRKESAAKMVLLHERSVSFIK RAAIEQSGPVKAVVKIEGVHVLHKTYEEWLPFVIRLTFYAGLSEIGLVHTQLIDRSGK LEFVKGLGIEFDLFLEGEPYNRHFRFAGEKGMYKEPAQLFGTRKFNERYPLYEKQING EMLSPDEEHKEWFAHGTQNAVWDDVKIVQDSSDHYSLSKRTGKDYAWVGMLHGSRAKG LCYAGGKNGGVALGLRYFFEKYPSALEITGLAGSRPKMTIWLWPPDGEAMDLRHYTGN THVASAYEGFDEMRSDPTGIANTNEISLACFSHMPSDEVLNALADKWQAPPLIVCEPD VYYESKALGVWSIIDTSHPLKKELEEQLDAAFLFYKKEVEQRRWYGFWHYGDVMHTYD PIRHMWRYDLGGYAWQNNELVPTLWLWQAFFRSGREDIFRMAEAMTRHTSETDSFHLG EYAGLGSRHNVVHWGCGCKEARISMAGLHKFYYYLTGDDRTGDLLTEVKDADYALVKT DPMRAFYEKGKHPTHARTGPDWAAFCSNWLAEWERTENSEYLKKIETGINCLKRLPLR LLSGPTFEYDPATSMLHHMGDGIAGGYHMIIAFGAPQVWMELAELLDDWEWEDMLSEF GEFYTLSDEEKRKKSGGALHDGHFHWPMFAAGMTAYAARKKQDPHLAAKAWNLLLEDK LSHTPLPIKPERIETWTQLEELPWVTTNTVSQWCLNVIAALELIGDSLPAKKETSGKK G*" /label="yetA CDS" gene 701059..703632 /gene="yetA" /locus_tag="BSU_07090" /old_locus_tag="BSU07090" /label="yetA gene" promotor_-10 complement(702381..702399) /Source="Nicolas_upshift_promotors" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(702394) /Source="Nicolas_upshifts" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(702415..702420) /Source="Nicolas_upshift_promotors" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 703754..705262 /gene="lplA" /locus_tag="BSU_07100" /old_locus_tag="BSU07100" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921237; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein transporter binding protein for alpha-galacturonides" /protein_id="NP_388591.1" /db_xref="EnsemblGenomes-Gn:BSU07100" /db_xref="EnsemblGenomes-Tr:CAB12529" /db_xref="GOA:P37966" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG10434" /db_xref="UniProtKB/Swiss-Prot:P37966" /translation="MKIRMRKKWMALPLAAMMIAGCSHSETSNSASGSKDTIKIMAPL LSPESPSDKSPSLKALEKYTGKEIKVTWVPDSSYNDKFNIVMASGEMPHAIVIKDKSA GFIKSVKAGAFWELSPYLKDYKNLSQADEKILKNSSVNGEVYGIYRTRDLIRACMIIR TDWLKNVGLDMPETLDDFYEVLKAFKEKDPDGNGKDDTYGMVVPKWMGLGNGSPWDVL QIWFGAPNRYGVENGKLIPDFTTKEYMDALTFFKKLYDEGLINKDFAVMDSAKWNDPV VKGKAGVIVDTGSRASQIQSAMEEADESNKDIIDIVGSLEGPNGKRTFPTSGYSGMIT IPKSSVKTEKELKEVLSFLDKMNDKEAQILTNNGVKGRNYELKDGVFTSLEKNNKSLL YEHEGLAQFSMSIPKSEYYIEDQKTKLFQHRKDIITEGEKIAVFNPAESLVSDVYTQK GAQLDNIILDARTQFIIGEIDEKGFDDAVELWKKSGGNELMKDLNKLYQSSK*" /label="lplA CDS" gene 703754..705262 /gene="lplA" /locus_tag="BSU_07100" /old_locus_tag="BSU07100" /label="lplA gene" CDS 705317..706273 /gene="lplB" /locus_tag="BSU_07110" /old_locus_tag="BSU07110" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10869078, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) for alpha-galacturonides" /protein_id="NP_388592.1" /db_xref="EnsemblGenomes-Gn:BSU07110" /db_xref="EnsemblGenomes-Tr:CAB12530" /db_xref="GOA:P39128" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10435" /db_xref="UniProtKB/Swiss-Prot:P39128" /translation="METVPKKRDAPVLTAGKGISWMAALKRDKWLYLLLIPGLLYFLI FKYLPMWGVLIAFKDYSPYLGFWKSEWVGFDYFKDFFMNPDFFRLLRNTLMLASLDLL FAFPAPLILALLLNEVRKAVYKRCIQTFIYVPHFVSWTIVVSITFVFFTVDTGVINKL IMSLTGEQISFLSDADWFRPMIVMQSIWKETGWGTILFLAALATVDQEQYEAAIMDGA GRFRRMWHITLPAIRSTIIVLLILRIGSFLNLGFEQVYLMTNSLNRSVADIFDTYVYM MGITQGAYSYSTAVGLFKSVVGIILIFGANYIAKKFDQEGLF*" /label="lplB CDS" gene 705317..706273 /gene="lplB" /locus_tag="BSU_07110" /old_locus_tag="BSU07110" /label="lplB gene" downshifts complement(705591) /Source="Nicolas_upshifts" /id="D344" /incds=1 /nref=1 /ntot=8 /MaxReadThrough="1.59638" /MaxDrop="4.19822" /score="13.9744253" /energy="-20.3" /TU="NA" /idTUdmin="U538" /TUdmin=2068 /isTUend="FALSE" /label="downshifts" promotor_no_box complement(705617..705717) /Source="Nicolas_upshift_promotors" /id="U536" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.002997002997003" /xcortree=1476 /SigmaFactorBS="ggtacgtaaataaaggtttggatacatcttttatacacggcc tttcttacctcattcaaaagcagagccaaaatgagaggcgcgggaaaggcaaacaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(705657) /Source="Nicolas_upshifts" /id="U536" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.002997002997003" /xcortree=1476 /SigmaFactorBS="ggtacgtaaataaaggtttggatacatcttttatacacggcc tttcttacctcattcaaaagcagagccaaaatgagaggcgcgggaaaggcaaacaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 706287..707174 /gene="lplC" /locus_tag="BSU_07120" /old_locus_tag="BSU07120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10869078, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) for alpha-galacturonides" /protein_id="NP_388593.1" /db_xref="EnsemblGenomes-Gn:BSU07120" /db_xref="EnsemblGenomes-Tr:CAB12531" /db_xref="GOA:P39129" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10857" /db_xref="UniProtKB/Swiss-Prot:P39129" /translation="MAEIHTMHNTKAGRVFDVCNILFLGGVGAITILPFLYIIAGSFA TEAELAQRSFFIFPKTFTLDAYKYVFSTPTFLRSMGVSIFITVVGTAVQLFFTFTMAY PLAKRHVKGRNLLLNLVIFSMLFSGGMIPTYLVVKSLGLLDTYWALILPMAINPFNLI IIKNFFQQLPRELEESAKIDGCSEIGVFWRIALPLSKPVIATFALFYAVGIWNDFFHA LLYINDSAKWPLQMVLRQVTILSDLTATNGDTMQNAVPPEQGIKLAVIVIATLPILAV YPFLQKHFAKGMLIGSVKG*" /label="lplC CDS" gene 706287..707174 /gene="lplC" /locus_tag="BSU_07120" /old_locus_tag="BSU07120" /label="lplC gene" promotor_-35 706921..706926 /Source="Nicolas_upshift_promotors" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 706942..706960 /Source="Nicolas_upshift_promotors" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 706945 /Source="Nicolas_upshifts" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" /label="upshifts" CDS 707183..708523 /gene="lplD" /locus_tag="BSU_07130" /old_locus_tag="BSU07130" /EC_number="3.2.1.67" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:23416295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23416295; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-galacturonidase" /protein_id="NP_388594.1" /db_xref="EnsemblGenomes-Gn:BSU07130" /db_xref="EnsemblGenomes-Tr:CAB12532" /db_xref="GOA:P39130" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="PDB:3FEF" /db_xref="SubtiList:BG10858" /db_xref="UniProtKB/Swiss-Prot:P39130" /translation="MFHISTLDQIKIAYIGGGSQGWARSLMSDLSIDERMSGTVALYD LDFEAAQKNEVIGNHSGNGRWRYEAVSTLKKALSAADIVIISILPGSLDDMEVDVHLP ERCGIYQSVGDTVGPGGIIRGLRAVPIFAEIARAIRDYAPESWVINYTNPMSVCTRVL YKVFPGIKAIGCCHEVFGTQKLLAEMVTERLGIEVPRREDIRVNVLGINHFTWITKAS YRHIDLLPIFREFSAHYGESGYELEGECWRDSVFCSAHRVAFDLFETYGAIPAAGDRH LAEFLPGPYLKQPEVWKFHLTPISFRKQDRAEKRQETERLIVQQRGVAEKASGEEGVN IIAALLGLGELVTNVNMPNQGQVLNLPIQAIVETNAFITRNRVQPILSGALPKGVEML AARHISNQEAVADAGLTKDTGLAFQAFLNDPLVQIDRSDAEQLFNDMLQCIMQS*" /label="lplD CDS" gene 707183..708523 /gene="lplD" /locus_tag="BSU_07130" /old_locus_tag="BSU07130" /label="lplD gene" S_feature complement(707617..709308) /Source="Nicolas_S_feature" /locus_tag="new_783392_785083_c" /HighExp="H2O2, dia15, Paraq, Lbexp, LBGexp, Salt, LPhT, GM 25, G150, dia0" /AntisenseName="yetF" /AntisenseCor="-0.25986434675098202" /AntisenseRegPval="-4.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S247" S_feature 708524..708605 /Source="Nicolas_S_feature" /locus_tag="new_784299_784380" /HighExp="S5, S4, S6, S3, S7, S8, BT, LoTm, B36, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S248" CDS 708606..709301 /gene="yetF" /locus_tag="BSU_07140" /old_locus_tag="BSU07140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388595.1" /db_xref="EnsemblGenomes-Gn:BSU07140" /db_xref="EnsemblGenomes-Tr:CAB12533" /db_xref="GOA:O31533" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="PDB:3C6F" /db_xref="SubtiList:BG12862" /db_xref="UniProtKB/Swiss-Prot:O31533" /translation="MGNYLSVAVELVCGLGILFIILKLLGKTQFSQITPFDFISALIL GELVGNAVYDHEIKIKEIIFASLLWGVLIYIIEFITQKMKSSRKFLEGEPNIVIRKGE LQYKVMKKNKIDINQLQSLLRQAGSFSIQEVEYAILETNGMVSVLPKSDFDKPTNKDL QIPSKSVSLPITLIIDGEIVRDNLKEAGVDEQWLKQELKKKNIDKTEDVLFAEWHKNK PLYTVTYEQSRST*" /label="yetF CDS" gene 708606..709301 /gene="yetF" /locus_tag="BSU_07140" /old_locus_tag="BSU07140" /label="yetF gene" downshifts 709299 /Source="Nicolas_upshifts" /id="D345" /incds=0 /nref=2 /ntot=24 /MaxReadThrough="1.32891" /MaxDrop="3.45213" /score="-0.176154378" /energy="-7.1" /TU="NA" /idTUdmin="U537" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(709338..709664) /gene="hmoA" /locus_tag="BSU_07150" /old_locus_tag="BSU07150" /EC_number="1.14.14.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:20180905, 21764939, 21873409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20180905, 21764939, 21873409; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heme-degrading monooxygenase" /protein_id="NP_388596.2" /db_xref="EnsemblGenomes-Gn:BSU07150" /db_xref="EnsemblGenomes-Tr:CAB12534" /db_xref="GOA:O31534" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="SubtiList:BG12863" /db_xref="UniProtKB/Swiss-Prot:O31534" /translation="MFVQLRKMTVKEGFADKVIERFSAEGIIEKQEGLIDVTVLEKNV RRGDEEVVVMIRWESEDHWKQWEKSDAHIAGHKANKGKPKPDYLISTEVSMYHVRAVK QGTYNQ*" /label="hmoA CDS" gene complement(709338..709664) /gene="hmoA" /locus_tag="BSU_07150" /old_locus_tag="BSU07150" /label="hmoA gene" downshifts complement(709353) /Source="Nicolas_upshifts" /id="D346" /incds=0 /nref=194 /ntot=248 /MaxReadThrough="4.01189" /MaxDrop="6.29183" /score="9.23596913" /energy="-9.1" /TU="U538" /idTUdmin="U539" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 709651 /Source="Nicolas_upshifts" /id="D347" /incds=1 /nref=1 /ntot=45 /MaxReadThrough="1.96802" /MaxDrop="3.46057" /score="-7.34187128" /energy="-5" /TU="NA" /idTUdmin="U537" /TUdmin=352 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(709687..709706) /Source="Nicolas_upshift_promotors" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(709705) /Source="Nicolas_upshifts" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(709721..709728) /Source="Nicolas_upshift_promotors" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(709768..710130) /gene="yetH" /locus_tag="BSU_07160" /old_locus_tag="BSU07160" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase/dioxygenase" /protein_id="NP_388597.1" /db_xref="EnsemblGenomes-Gn:BSU07160" /db_xref="EnsemblGenomes-Tr:CAB12535" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12864" /db_xref="UniProtKB/Swiss-Prot:O31535" /translation="MIKQIGTVAVYVEDQQKAKQFWTEKVGFDIAADHPMGPEASWLE VAPKGAETRLVIYPKAMMKGSEQMKASIVFECEDIFGTYEKMKTNGVEFLGEPNQMEW GTFVQFKDEDGNVFLLKE*" /label="yetH CDS" gene complement(709768..710130) /gene="yetH" /locus_tag="BSU_07160" /old_locus_tag="BSU07160" /label="yetH gene" promotor_-10 complement(710153..710172) /Source="Nicolas_upshift_promotors" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" /label="promotor_-10" upshifts complement(710167) /Source="Nicolas_upshifts" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" /label="upshifts" promotor_-35 complement(710185..710191) /Source="Nicolas_upshift_promotors" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" /label="promotor_-35" S_feature complement(710201..710761) /Source="Nicolas_S_feature" /locus_tag="new_785976_786536_c" /HighExp="S8, S6, S7, S5, BT, B36, G/S, B60, Pyr, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99999400000000005" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S249" downshifts complement(710233) /Source="Nicolas_upshifts" /id="D348" /incds=0 /nref=38 /ntot=47 /MaxReadThrough="0.395850000000001" /MaxDrop="8.2984" /score="45.4672528" /energy="-13.7" /TU="NA" /idTUdmin="U540" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(710744..710763) /Source="Nicolas_upshift_promotors" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(710761) /Source="Nicolas_upshifts" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(710777..710786) /Source="Nicolas_upshift_promotors" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 710849..710856 /Source="Nicolas_upshift_promotors" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 710865 /Source="Nicolas_upshifts" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 710869..710888 /Source="Nicolas_upshift_promotors" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 710914..711495 /gene="yetI" /locus_tag="BSU_07170" /old_locus_tag="BSU07170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11157946; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="putative paralog of RsbR; N-terminal part of YetI" /db_xref="SubtiList:BG12865" /translation="MNIDQLLYQYIIDNTADITEKWFSLRCQLKGELYSASHLSEETK TLLTEQHTFTNITIASAFLEDQTDFQENMTKWAQNVAKNRVEQDVQVHEVVEAISNSR ISFWDAVATFIKENQEIVTNEDADRWNRIVNQSFDKLIIEFSEQYQKFMLMRLTSQQE LISELGCPVISIADGIGILPLIGSIDTKRHRSF*" /label="yetI CDS" gene 710914..711495 /gene="yetI" /locus_tag="BSU_07170" /old_locus_tag="BSU07170" /pseudo /label="yetI gene" CDS 711489..711785 /gene="yetI" /locus_tag="BSU_07180" /old_locus_tag="BSU07180" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11157946; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="putative paralog of RsbR; C-terminal part of YetI" /db_xref="GOA:O31537" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="PSEUDO:CAB12537.2" /db_xref="SubtiList:BG12873" /db_xref="UniProtKB/Swiss-Prot:O31537" /translation="MLETVPVRCVERKITSLVVDLSGVPIVDTMVAQQLYNLSKTLFL LGVKAVFSGIRPDVAQTSIQLGLDFSEYETYGTLKQALENMGVRCIVEELEENK*" /label="yetI CDS" gene 711489..711785 /gene="yetI" /locus_tag="BSU_07180" /old_locus_tag="BSU07180" /pseudo /label="yetI gene" downshifts 711777 /Source="Nicolas_upshifts" /id="D349" /incds=0 /nref=114 /ntot=215 /MaxReadThrough="1.06939" /MaxDrop="4.8053" /score="16.356572" /energy="-21.2" /TU="NA" /idTUdmin="U541" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 711856..711863 /Source="Nicolas_upshift_promotors" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 711877..711896 /Source="Nicolas_upshift_promotors" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 711885 /Source="Nicolas_upshifts" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" /label="upshifts" CDS 711940..712107 /gene="yezD" /locus_tag="BSU_07190" /old_locus_tag="BSU07190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388600.1" /db_xref="EnsemblGenomes-Gn:BSU07190" /db_xref="EnsemblGenomes-Tr:CAB12538" /db_xref="InterPro:IPR018743" /db_xref="SubtiList:BG12875" /db_xref="UniProtKB/Swiss-Prot:O31538" /translation="MVSKSTIDPEVIEKIISSLETLDFGTVQITVHDSQITQIEKIEK HRFSLKRKESK*" /label="yezD CDS" gene 711940..712107 /gene="yezD" /locus_tag="BSU_07190" /old_locus_tag="BSU07190" /label="yezD gene" promotor_-35 712149..712156 /Source="Nicolas_upshift_promotors" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 712172..712191 /Source="Nicolas_upshift_promotors" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 712173 /Source="Nicolas_upshifts" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" /label="upshifts" CDS 712217..712861 /gene="calJ" /locus_tag="BSU_07200" /old_locus_tag="BSU07200" /function="7.4: Cations and iron carrying compounds" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 16086852, 24904158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 16086852, 24904158; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pH-sensitive calcium-leak permease (di-aspartyl pH sensor)" /protein_id="NP_388601.1" /db_xref="EnsemblGenomes-Gn:BSU07200" /db_xref="EnsemblGenomes-Tr:CAB12539" /db_xref="GOA:O31539" /db_xref="InterPro:IPR006214" /db_xref="PDB:4PGR" /db_xref="PDB:4PGS" /db_xref="PDB:4PGU" /db_xref="PDB:4PGV" /db_xref="PDB:4PGW" /db_xref="PDB:4TKQ" /db_xref="SubtiList:BG12866" /db_xref="UniProtKB/Swiss-Prot:O31539" /translation="MQATVHESKQSIMQRILTVFVFTLLIATVGLFIGQFVPVALMLP LSILEVAMIILAFWMRRRKAVGYAFVYTFAFVSGITLFPIVSHYASIAGAYVVLEAFG STFVIFAVLGTIGAKMKKDLSFLWSFLLVAVLALAVVGIFNIFSPLNSAAMMAYSVIG TIVFSLYILYDLNQIKHRHITEDLIPVMALSLYLDFINLFINLLRFFGILSSDD*" /label="calJ CDS" gene 712217..712861 /gene="calJ" /locus_tag="BSU_07200" /old_locus_tag="BSU07200" /label="calJ gene" downshifts 712797 /Source="Nicolas_upshifts" /id="D350" /incds=1 /nref=1 /ntot=11 /MaxReadThrough="6.69003" /MaxDrop="2.5446" /score="-1.46791202" /energy="-10.7" /TU="U542,U543" /idTUdmin="U541" /TUdmin=1012 /isTUend="FALSE" /label="downshifts" downshifts 712841 /Source="Nicolas_upshifts" /id="D351" /incds=0 /nref=7 /ntot=127 /MaxReadThrough="5.33515" /MaxDrop="3.71552" /score="-1.46791202" /energy="-10.7" /TU="U542,U543" /idTUdmin="U542" /TUdmin="-990" /isTUend="FALSE" /label="downshifts" CDS 712861..713853 /gene="yetK" /locus_tag="BSU_07210" /old_locus_tag="BSU07210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388602.1" /db_xref="EnsemblGenomes-Gn:BSU07210" /db_xref="EnsemblGenomes-Tr:CAB12540" /db_xref="GOA:O31540" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12867" /db_xref="UniProtKB/Swiss-Prot:O31540" /translation="MKKRLSLDRRFLPYIKKAGGVLVKKQMGAYVSLAAAMAIVGSSV VVGKLMVERIPVFLSSGLRFLIASVVLLMLLFCIEKGFPALTKKDVFVLLVQSFTGVF LFSICLLYGVQYTTGTESGILTSTTPMLIGILSFFLLREKIEKKTLIGILLAVCGVMA INLFGAGSQDGTPHALFGNMLIIAAVIGEALFTLMAKLLSPHISALAISTFVSLFGFL FFLPFALFEASSFDYSVPTVLDWSYVLYYALFVTVLAFYLWYSGVTKVPAGVSGIFTS VLPVSAVILSGVILKEPFEFVHFIGIACVIGGIFVTVIKKKQPDAYPAAEEKTL*" /label="yetK CDS" gene 712861..713853 /gene="yetK" /locus_tag="BSU_07210" /old_locus_tag="BSU07210" /label="yetK gene" downshifts 713787 /Source="Nicolas_upshifts" /id="D352" /incds=1 /nref=1 /ntot=18 /MaxReadThrough="4.14475" /MaxDrop="2.73453" /score="21.8095329" /energy="-10.7" /TU="U542,U543" /idTUdmin="U542" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 713831 /Source="Nicolas_upshifts" /id="D353" /incds=0 /nref=94 /ntot=214 /MaxReadThrough="0.120229999999999" /MaxDrop="4.45909" /score="21.8095329" /energy="-10.7" /TU="NA" /idTUdmin="U542" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(713877..714380) /gene="flvL" /locus_tag="BSU_07220" /old_locus_tag="BSU07220" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19329649, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19329649, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (FlvL-flavonoids)" /protein_id="NP_388603.1" /db_xref="EnsemblGenomes-Gn:BSU07220" /db_xref="EnsemblGenomes-Tr:CAB12541" /db_xref="GOA:O31541" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12868" /db_xref="UniProtKB/Swiss-Prot:O31541" /translation="MELKHLPKYKHITEHAETYANIDAGSLELFLSLFDISKKMNHVM EHYFAGRGLSEGKFKILMLLFDAKDHRLSPTELAKRSNVTKATITGLLDGLARDGFVS RRHHTEDKRKISIELTTEGKARLEQFLPGHFSKISAVMENYSDEEKDMFVKMLGDLFE RLSVFKD*" /label="flvL CDS" gene complement(713877..714380) /gene="flvL" /locus_tag="BSU_07220" /old_locus_tag="BSU07220" /label="flvL gene" promotor_-10 complement(714405..714424) /Source="Nicolas_upshift_promotors" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(714413) /Source="Nicolas_upshifts" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(714438..714445) /Source="Nicolas_upshift_promotors" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 714543..715652 /gene="flvM" /locus_tag="BSU_07230" /old_locus_tag="BSU07230" /EC_number="1.14.13.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25209494; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavin-dependent hydroxylase/monooxygenase acting on salicylate derivatives" /protein_id="NP_388604.1" /db_xref="EnsemblGenomes-Gn:BSU07230" /db_xref="EnsemblGenomes-Tr:CAB12542" /db_xref="GOA:O06489" /db_xref="InterPro:IPR002938" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12869" /db_xref="UniProtKB/Swiss-Prot:O06489" /translation="MKHMLIAGGGIGGLSAAISLRKAGFSVTLCEAASENRKTGAGIL QPQNALAVLKELGVFEDCCKHGFQTEWFKTFDEQGNLLFQVSESFLDDSLPGRNNILR KTLNDILMKHAEAVGVDIKWGKKVVAYEETAESVTALCEDGEKMQADILAGFDGIHSV VRDKMLQKETEKEHLGMGAWRFYIELPDYTFEDATFMYRSGDTQIGVVPLAQHAGYVF VLQPCTSDYWDEEDTRFDRVKEILSGFRGLDFVTKHMSKQHPVIFNKLEQVAVQEPWH KGRVIIGGDAAHAGAPTLAQGAAMAIEDAIVLAEELQNHADHETALQAYYKRRAPRAL KVQNLSSEIVRRRLKGEPGAEELIGECYAVLREGY*" /label="flvM CDS" gene 714543..715652 /gene="flvM" /locus_tag="BSU_07230" /old_locus_tag="BSU07230" /label="flvM gene" downshifts 715635 /Source="Nicolas_upshifts" /id="D354" /incds=0 /nref=7 /ntot=67 /MaxReadThrough="0.0953400000000002" /MaxDrop="5.1482" /score="13.261567" /energy="-12.6" /TU="NA" /idTUdmin="U542" /TUdmin=1804 /isTUend="FALSE" /label="downshifts" CDS complement(715687..716757) /gene="yetN" /locus_tag="BSU_07240" /old_locus_tag="BSU07240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388605.1" /db_xref="EnsemblGenomes-Gn:BSU07240" /db_xref="EnsemblGenomes-Tr:CAB12543" /db_xref="InterPro:IPR025006" /db_xref="InterPro:IPR025012" /db_xref="SubtiList:BG12870" /db_xref="UniProtKB/Swiss-Prot:O06490" /translation="MDFEIRFLSFYVIQVEGKDEQANKQFKHFQTLDTGEFEESELKD FLDGELKKIVKRKADRHPQSEQVPTKIGHFIVEPGHELDSNPNYNMFNRARLAETKED FNELSEQFVRTYLDTSAVRGGVFLVASAVPRKYFDESFVFIMKCDFEPKVARISDASS LIKKVEMAITTKNMKSIQYPYMPEEGMVEEGELKIHQASHARYFEDFLKFVEYGESMP EIMKNQVMNMVQEHVYETFEDNSEELKQFEHDIEIWEASEKREIQERLDTHQVIEASA QIIEHTPEAQLKMKVGETEIKGLLADFGDSIHLAKVNGRYVALIEAETISFEKGSSPV EFYKPEGLHEVIERIRNKTEQD*" /label="yetN CDS" gene complement(715687..716757) /gene="yetN" /locus_tag="BSU_07240" /old_locus_tag="BSU07240" /label="yetN gene" downshifts complement(715711) /Source="Nicolas_upshifts" /id="D355" /incds=0 /nref=45 /ntot=180 /MaxReadThrough="0.83729" /MaxDrop="4.28938" /score="0.323038441" /energy="-11.6" /TU="NA" /idTUdmin="U545" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(716788..716807) /Source="Nicolas_upshift_promotors" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(716814) /Source="Nicolas_upshifts" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(716822..716829) /Source="Nicolas_upshift_promotors" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 716837..716843 /Source="Nicolas_upshift_promotors" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 716858..716876 /Source="Nicolas_upshift_promotors" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 716867 /Source="Nicolas_upshifts" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" /label="upshifts" CDS 716907..720092 /gene="cypD" /locus_tag="BSU_07250" /old_locus_tag="BSU07250" /EC_number="1.6.2.4" /EC_number="1.14.14.1" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11574077, 2544578, 21048857, 26452461; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional P-450/NADPH-P450 reductase 1" /protein_id="NP_388606.1" /db_xref="EnsemblGenomes-Gn:BSU07250" /db_xref="EnsemblGenomes-Tr:CAB12544" /db_xref="GOA:O08394" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR023206" /db_xref="InterPro:IPR029039" /db_xref="InterPro:IPR036396" /db_xref="SubtiList:BG12871" /db_xref="UniProtKB/Swiss-Prot:O08394" /translation="MKETSPIPQPKTFGPLGNLPLIDKDKPTLSLIKLAEEQGPIFQI HTPAGTTIVVSGHELVKEVCDEERFDKSIEGALEKVRAFSGDGLFTSWTHEPNWRKAH NILMPTFSQRAMKDYHEKMVDIAVQLIQKWARLNPNEAVDVPGDMTRLTLDTIGLCGF NYRFNSYYRETPHPFINSMVRALDEAMHQMQRLDVQDKLMVRTKRQFRYDIQTMFSLV DSIIAERRANGDQDEKDLLARMLNVEDPETGEKLDDENIRFQIITFLIAGHETTSGLL SFATYFLLKHPDKLKKAYEEVDRVLTDAAPTYKQVLELTYIRMILNESLRLWPTAPAF SLYPKEDTVIGGKFPITTNDRISVLIPQLHRDRDAWGKDAEEFRPERFEHQDQVPHHA YKPFGNGQRACIGMQFALHEATLVLGMILKYFTLIDHENYELDIKQTLTLKPGDFHIS VQSRHQEAIHADVQAAEKAAPDEQKEKTEAKGASVIGLNNRPLLVLYGSDTGTAEGVA RELADTASLHGVRTKTAPLNDRIGKLPKEGAVVIVTSSYNGKPPSNAGQFVQWLQEIK PGELEGVHYAVFGCGDHNWASTYQYVPRFIDEQLAEKGATRFSARGEGDVSGDFEGQL DEWKKSMWADAIKAFGLELNENADKERSTLSLQFVRGLGESPLARSYEASHASIAENR ELQSADSDRSTRHIEIALPPDVEYQEGDHLGVLPKNSQTNVSRILHRFGLKGTDQVTL SASGRSAGHLPLGRPVSLHDLLSYSVEVQEAATRAQIRELASFTVCPPHRRELEELSA EGVYQEQILKKRISMLDLLEKYEACDMPFERFLELLRPLKPRYYSISSSPRVNPRQAS ITVGVVRGPAWSGRGEYRGVASNDLAERQAGDDVVMFIRTPESRFQLPKDPETPIIMV GPGTGVAPFRGFLQARDVLKREGKTLGEAHLYFGCRNDRDFIYRDELERFEKDGIVTV HTAFSRKEGMPKTYVQHLMADQADTLISILDRGGRLYVCGDGSKMAPDVEAALQKAYQ AVHGTGEQEAQNWLRHLQDTGMYAKDVWAGI*" /label="cypD CDS" gene 716907..720092 /gene="cypD" /locus_tag="BSU_07250" /old_locus_tag="BSU07250" /label="cypD gene" downshifts 720079 /Source="Nicolas_upshifts" /id="D356" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="2.31156" /MaxDrop="2.91666" /score="9.17315362" /energy="-9.8" /TU="NA" /idTUdmin="U546" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 720142..720147 /Source="Nicolas_upshift_promotors" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 720163..720181 /Source="Nicolas_upshift_promotors" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 720184 /Source="Nicolas_upshifts" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 720212..720215 /Source="Nicolas_upshift_promotors" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 720232..720251 /Source="Nicolas_upshift_promotors" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 720233..720538 /Source="Nicolas_S_feature" /locus_tag="new_796008_796313" /HighExp="H2O2, Paraq, Oxctl, Cold, Heat, LBGexp, G180, G150, HPh, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.841" /TUlongSig="NA" /TUlongPSig="NA" /label="S250" upshifts 720233 /Source="Nicolas_upshifts" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="upshifts" CDS 720539..722458 /gene="ltaSA" /locus_tag="BSU_07260" /old_locus_tag="BSU07260" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11544192, 15187182, 17434969, 17483484, 21255105, 27002131; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="exported glycerol phosphate lipoteichoic acid synthetase and anion-binding protein" /protein_id="NP_388607.2" /db_xref="EnsemblGenomes-Gn:BSU07260" /db_xref="EnsemblGenomes-Tr:CAB12545" /db_xref="GOA:Q797B3" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG12980" /db_xref="UniProtKB/Swiss-Prot:Q797B3" /translation="MKKLFSYKLSFFVLAVILFWAKTYLSYKTEFNLGVKGTTQEILL IFNPFSSAVFFLGLALLAKGRKSAIIMLIIDFLMTFVLYANILFYRFFDDFLTFPNIK QSGNVGNMGDGIFSIMAGHDIFYFLDIIILIAVLIWRPELKEYKMKKRFASLVILSGI ALFFINLHYAEKDRPQLLTRTFDRNYIVKYLGLYNYTIYDGVQTAQTETQRAYASSDD LTSVENYTTSHYAKPNAEYFGSAKGKNIIKIHLESFQSFLIDYKLNGEEVTPFLNKLA HGGEDVTYFDNFFHQTGQGKTSDAELTMDNSIFGLPEGSAFVTKGENTYQSLPAILDQ KEGYTSAVLHGDYKSFWNRDQIYKHIGYDKFFDASTYDMSDENVINMGLKDKPFFTES IPKLESLKQPFYAHLITLTNHYPFNLDEKDASLKKATTGDNTVDSYFQTARYLDEALE QFFKELKEAGLYDNSVIMIYGDHNGISENHNRAMKEILGKEITDYQNAQNQRVPLMIR VPGKKGGVNHTYGGEIDVMPTLLHLEGIDSQKYINFGTDLFSKDHDDTVAFRNGDFVT PKYTSVDNIIYDTKTGEKLKANEETKNLKTRVNQQLSLSDSVLYKDLLRFHKLNDFKA VDPSDYHYGKEKEIK*" /label="ltaSA CDS" gene 720539..722458 /gene="ltaSA" /locus_tag="BSU_07260" /old_locus_tag="BSU07260" /label="ltaSA gene" downshifts 722457 /Source="Nicolas_upshifts" /id="D357" /incds=0 /nref=103 /ntot=261 /MaxReadThrough="1.69168" /MaxDrop="7.8227" /score="37.7648461" /energy="-24" /TU="NA" /idTUdmin="U547" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 722546..722555 /Source="Nicolas_upshift_promotors" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 722565..722693 /Source="Nicolas_S_feature" /locus_tag="new_798340_798468" /HighExp="BT, B36, S8, S7, G/S, Pyr, B60, S6, Glucon, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S251" upshifts 722565 /Source="Nicolas_upshifts" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 722569..722588 /Source="Nicolas_upshift_promotors" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(722619) /Source="Nicolas_upshifts" /id="D358" /incds=0 /nref=2 /ntot=6 /MaxReadThrough="1.80969" /MaxDrop="4.63324" /score="20.6569889" /energy="-23.4" /TU="NA" /idTUdmin="U552" /TUdmin=4928 /isTUend="FALSE" /label="downshifts" CDS 722694..723458 /gene="spmH" /locus_tag="BSU_07270" /old_locus_tag="BSU07270" /EC_number="2.7.7.33" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15634670, 16357223, 26577401" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15634670, 16357223, 26577401; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate cytidylyltransferase (sporulation)" /protein_id="NP_388608.1" /db_xref="EnsemblGenomes-Gn:BSU07270" /db_xref="EnsemblGenomes-Tr:CAB12546" /db_xref="GOA:O06486" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR013446" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12979" /db_xref="UniProtKB/Swiss-Prot:O06486" /translation="MKAVILCGGKGTRMSEVTNDIPKPLAMIGGKPILWHIMKIYQYY GVNEFILLLGYKGEKIKEYFLDYEWKHNSLTLDSSTGEVQMLGQPETWKITFLETGVD TLTAGRILQAKDYIGDETFLLTYGDGLANINLFHLISYHQTKGAAATVTGIDKVSQFG TLTVEDGMAKTFSEKTSSDGIINGGFFVLSPKVFDYLPKDGNTMFEDEPLKNLAKDGE LAVYRHYGFWTAIDTYKNLLEVNKMWNQGQQVWKVW*" /label="spmH CDS" gene 722694..723458 /gene="spmH" /locus_tag="BSU_07270" /old_locus_tag="BSU07270" /label="spmH gene" CDS 723465..724433 /gene="spmG" /locus_tag="BSU_07280" /old_locus_tag="BSU07280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative CDP-sugar-dehydratase/epimerase" /protein_id="NP_388609.2" /db_xref="EnsemblGenomes-Gn:BSU07280" /db_xref="EnsemblGenomes-Tr:CAB12547" /db_xref="GOA:O06485" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12978" /db_xref="UniProtKB/Swiss-Prot:O06485" /translation="MSFWKNKNVFVTGCTGLLGSYLVKELIEQGANVTGLVRDHVPQS NLYQGEHIKKMNIVRGSLEDLAVIERALGEYEIDTVFHLAAQAIVGVANRNPISTFEA NILGTWNILEACRKHPLIKRVIVASSDKAYGDQENLPYDENMPLQGKHPYDVSKSCAD LISHTYFHTYGLPVCITRCGNLYGGGDLNFNRIIPQTIQLVLNGEAPEIRSDGTFVRD YFYIEDAVQAYLLLAEKMEENNLAGEAFNFSNEIQLTVLELVEKILKKMNSNLKPKVL NQGSNEIKHQYLSAEKARKLLNWTPAYTIDEGLEKTIEWYTEFFKK*" /label="spmG CDS" gene 723465..724433 /gene="spmG" /locus_tag="BSU_07280" /old_locus_tag="BSU07280" /label="spmG gene" CDS 724457..725368 /gene="yfnF" /locus_tag="BSU_07290" /old_locus_tag="BSU07290" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_388610.1" /db_xref="EnsemblGenomes-Gn:BSU07290" /db_xref="EnsemblGenomes-Tr:CAB12548" /db_xref="InterPro:IPR005069" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12977" /db_xref="UniProtKB/Swiss-Prot:O06484" /translation="MTSAYCTVLSKGRLYQAVALFKSLEQVDQDSPIFILCMDEDTHR VLQKLKMKQLNLVPVAALENELLLKLKETRDQSEYCWTMKPIFLQAVLNSNPELERVT YIDGDLFFYADPSPIFENQPDCSVLLSRGDIVIPSFEKEQIDMLQRLLGRYNSGFISF KHDDAGTDCLEWWKERCLEECKNAPGEGKFGDQGYLDYMSELFPNVCDITTPGVNIGH WNYGQHTFSWKDGRIVLEDGSPLIFYHFSGYRIVSINEIKQIHETTRTDLPFVHELYQ ETLPHIIQHMQTLDPEFNGFASKDDNK*" /label="yfnF CDS" gene 724457..725368 /gene="yfnF" /locus_tag="BSU_07290" /old_locus_tag="BSU07290" /label="yfnF gene" promotor_-35 725246..725255 /Source="Nicolas_upshift_promotors" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 725268..725287 /Source="Nicolas_upshift_promotors" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 725271 /Source="Nicolas_upshifts" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="upshifts" CDS 725397..726575 /gene="yfnE" /locus_tag="BSU_07300" /old_locus_tag="BSU07300" /EC_number="2.4.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (complex carbohydrate synthase)" /protein_id="NP_388611.1" /db_xref="EnsemblGenomes-Gn:BSU07300" /db_xref="EnsemblGenomes-Tr:CAB12549" /db_xref="GOA:O06483" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12976" /db_xref="UniProtKB/Swiss-Prot:O06483" /translation="MKASVIIPAYNSKERLYNSLLSLNQQECDEEFEVIVADNGSEDG TLSMLESFQADFPLIFTRIKENRGIAYGRNQALRNARGDILIFHDSDMLAAKDLVAKH IKAHENEENLVVCGLFWKRIYSFYYERFEEEHKEQLAKLTGEMPKKDKQKLLEEADIK NGSFLDKSFDLDTDFIDVLKKILDEYGDDLKGYHMPWRFFITNNSSVKRKHVVDLGLF DEGIVRYGFEDYDLGIRLHQAGLTFRLRRDIVSVHQEHPSNCKSVDDIRANIAYMCDK YNNIRSLDVHLAFNGPFPPDMTNRIMADIQKLLESQKYDMLLNLFLELLHVVKERNID PDWRKKSPRVTAKSFDLQTVRKLLPKAKKKLGVNDFANALYALVNDLLHVDLRSLDVV *" /label="yfnE CDS" gene 725397..726575 /gene="yfnE" /locus_tag="BSU_07300" /old_locus_tag="BSU07300" /label="yfnE gene" promotor_-35 726116..726122 /Source="Nicolas_upshift_promotors" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 726137..726156 /Source="Nicolas_upshift_promotors" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 726151 /Source="Nicolas_upshifts" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 726576..727511 /gene="yfnD" /locus_tag="BSU_07310" /old_locus_tag="BSU07310" /EC_number="2.4.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (complex carbohydrate synthase)" /protein_id="NP_388612.1" /db_xref="EnsemblGenomes-Gn:BSU07310" /db_xref="EnsemblGenomes-Tr:CAB12550" /db_xref="InterPro:IPR005069" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12975" /db_xref="UniProtKB/Swiss-Prot:O31542" /translation="MSTFHFSTIVSRTHIFKLMPMIHSLHEHCDDFHLYVLCVDQKAY ELLQHVPWEHVTFVQLHEMEDPELLKAKSNRTFHEYCWTLKPAFLFHVMSKWDDAEYF AHMDTDLFFFSDPARIFAENPTASLYLTDHRNSPRFMSYYDRTGRFNTGFVGAGNTKE AYEAVWQWRQDCIEFCTVEMDTERKTYGDQRYVEKWPEQFKGVHVVKSIGANTALWNI ENYKVGQKDGRVYIDETPLIFYHFSGFTLVTEKEFNLCWYYRIEDEATIKMIYMPYIL NLKRWIDEIQSAFPDFADGFIPKHAVPDTHFIQLD*" /label="yfnD CDS" gene 726576..727511 /gene="yfnD" /locus_tag="BSU_07310" /old_locus_tag="BSU07310" /label="yfnD gene" downshifts 727383 /Source="Nicolas_upshifts" /id="D359" /incds=1 /nref=1 /ntot=52 /MaxReadThrough="5.41459" /MaxDrop="2.6465" /score="34.8532284" /energy="-15.2" /TU="U549,U550" /idTUdmin="U549" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 727493 /Source="Nicolas_upshifts" /id="D360" /incds=0 /nref=2 /ntot=30 /MaxReadThrough="2.32849" /MaxDrop="5.65066" /score="34.8532284" /energy="-15.2" /TU="NA" /idTUdmin="U549" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(727534) /Source="Nicolas_upshifts" /id="D361" /incds=0 /nref=158 /ntot=249 /MaxReadThrough="1.15199" /MaxDrop="4.97014" /score="32.9697757" /energy="-15.2" /TU="NA" /idTUdmin="U552" /TUdmin=13 /isTUend="TRUE" /label="downshifts" CDS complement(727542..728771) /gene="yfnC" /locus_tag="BSU_07320" /old_locus_tag="BSU07320" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388613.1" /db_xref="EnsemblGenomes-Gn:BSU07320" /db_xref="EnsemblGenomes-Tr:CAB12551" /db_xref="GOA:O06481" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12974" /db_xref="UniProtKB/Swiss-Prot:O06481" /translation="MAIAAPLKEKTVQKPGTTVYPILIIIGICHMLNDSLQAVIPAMF PILERSMSLTFTQLGIIAFTLNMVSSVMQPVVGWYTDKRPRPYALPVGLTASMLGILG LAFAPSFITILCCVFFIGLGSAIFHPEGSRVAYMAAGTKRGLAQSIYQVGGNSGQAMA PLITALILVPLGQFGAVWFTLVAALAVMFLMYIAKWYASRLGSLAQKSGKQKKTAENT AITKSVVSALIIIIFLIFARSWYTSAIGNFYTFYAMDTYHVSIQQAQSYIFVFLLFGA IGTFLGGPLADRFGKRFVILGSLLCSAPLAIVLPFAGPVLAYGVLALIGLVLMSSFSV TVVYAQELVPGKIGTMSGLTVGLAFGMGAIGAVALGALIDAAGLTPTMIAIAFLPVLG ILAFLLPSDQKLREWHS*" /label="yfnC CDS" gene complement(727542..728771) /gene="yfnC" /locus_tag="BSU_07320" /old_locus_tag="BSU07320" /label="yfnC gene" promotor_-10 complement(728800..728819) /Source="Nicolas_upshift_promotors" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(728818) /Source="Nicolas_upshifts" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(728835..728842) /Source="Nicolas_upshift_promotors" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(728882..729589) /gene="pynN" /locus_tag="BSU_07330" /old_locus_tag="BSU07330" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine nucleotide phosphatase (promiscuous)" /protein_id="NP_388614.1" /db_xref="EnsemblGenomes-Gn:BSU07330" /db_xref="EnsemblGenomes-Tr:CAB12552" /db_xref="GOA:O06480" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR011951" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3ED5" /db_xref="PDB:3I76" /db_xref="SubtiList:BG12973" /db_xref="UniProtKB/Swiss-Prot:O06480" /translation="MKRYRTLLFDVDDTILDFQAAEALALRLLFEDQNIPLTNDMKAQ YKTINQGLWRAFEEGKMTRDEVVNTRFSALLKEYGYEADGALLEQKYRRFLEEGHQLI DGAFDLISNLQQQFDLYIVTNGVSHTQYKRLRDSGLFPFFKDIFVSEDTGFQKPMKEY FNYVFERIPQFSAEHTLIIGDSLTADIKGGQLAGLDTCWMNPDMKPNVPEIIPTYEIR KLEELYHILNIENTVSC*" /label="pynN CDS" gene complement(728882..729589) /gene="pynN" /locus_tag="BSU_07330" /old_locus_tag="BSU07330" /label="pynN gene" downshifts complement(728911) /Source="Nicolas_upshifts" /id="D362" /incds=0 /nref=25 /ntot=169 /MaxReadThrough="2.75071" /MaxDrop="4.28644" /score="1.09492978" /energy="-15.7" /TU="NA" /idTUdmin="U553" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(729612..729631) /Source="Nicolas_upshift_promotors" /id="U553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.998001998001998" /xcortree=3118 /SigmaFactorBS="ttattaaacaaataatctcttttcagccggcggtgcctcacc cgccggctttttcctttttttaTGTGCTATACTTTGAATACAtatgagaaagggagac a" /listShort="yfnB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(729635) /Source="Nicolas_upshifts" /id="U553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.998001998001998" /xcortree=3118 /SigmaFactorBS="ttattaaacaaataatctcttttcagccggcggtgcctcacc cgccggctttttcctttttttaTGTGCTATACTTTGAATACAtatgagaaagggagac a" /listShort="yfnB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(729681..731066) /gene="mtrA" /locus_tag="BSU_07340" /old_locus_tag="BSU07340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12022921, 15849754, 16850406, 17114254, 18632116" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 15849754, 16850406, 17114254, 18632116; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methylthioribose permease" /protein_id="NP_388615.1" /db_xref="EnsemblGenomes-Gn:BSU07340" /db_xref="EnsemblGenomes-Tr:CAB12553" /db_xref="GOA:Q797A7" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12972" /db_xref="UniProtKB/Swiss-Prot:Q797A7" /translation="MSSLFRKKPLETLSAQSKSKSLARTLSAFDLTLLGIGCVIGTGI FVITGTVAATGAGPALIISFILAGLACALAAFCYAEFSSSIPISGSVYSYSYVTLGEL LAFLIGWDLMLEYVIALSAVATGWSSYFQSLLAGFNLHIPAALTGAPGSMAGAVFNLP AAVIILLITAIVSRGVKESTRFNNVIVLMKIAIILLFIIVGIGYVKPDNWSPFMPFGM KGVILSAATVFFAYLGFDAVSNASEEVKNPQKNMPVGIISALAVCTVLYIAVSLVLTG MMPYAKLNVGDPVSFALKFVGQDAVAGIISVGAIIGITTVMLALLYAQVRLTFAMSRD GLLPGLFAKVHPSFKTPFRNTWLTGIVAAGIAGFINLGTLAHLVNMGTLAAFTVISIA VIVLRKKHPEIKASFRVPFVPVVPIISAGICLWFMYSLPGVTWLSFVIWIAVGTLVYF LYSRKHSLLNK*" /label="mtrA CDS" gene complement(729681..731066) /gene="mtrA" /locus_tag="BSU_07340" /old_locus_tag="BSU07340" /label="mtrA gene" downshifts complement(729703) /Source="Nicolas_upshifts" /id="D363" /incds=0 /nref=8 /ntot=91 /MaxReadThrough="3.68565" /MaxDrop="4.73728" /score="31.1617384" /energy="-15.4" /TU="U554" /idTUdmin="U554" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(731115..731134) /Source="Nicolas_upshift_promotors" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(731132) /Source="Nicolas_upshifts" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(731149..731156) /Source="Nicolas_upshift_promotors" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 731234..731241 /Source="Nicolas_upshift_promotors" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 731249 /Source="Nicolas_upshifts" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 731255..731273 /Source="Nicolas_upshift_promotors" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 731316..732773 /gene="vdhT" /locus_tag="BSU_07350" /old_locus_tag="BSU07350" /EC_number="1.2.1.67" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15033535, 26658822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="vanillin dehydrogenase" /protein_id="NP_388616.1" /db_xref="EnsemblGenomes-Gn:BSU07350" /db_xref="EnsemblGenomes-Tr:CAB12554" /db_xref="GOA:O06478" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12971" /db_xref="UniProtKB/Swiss-Prot:O06478" /translation="MFQYEELNKQFIGGKWQEGSSPNVLENKNPYTQKTFTTFRKATA DDVDEAYRAAALAKKKWDAVNPFEKRTILEKAVTYIEENEEAIIYLIMEELGGTRLKA AFEIGLVKNIIKEAATFPIRMEGKILPSTIDGKENRLYRVPAGVVGVISPFNFPFFLS MKSVAPALGAGNGVVLKPHEETPICGGTLIAKIFENAGIPAGLLNVVVTDIAEIGDSF VEHPVPRIISFTGSTKVGSYIGQLAMKHFKKPLLELGGNSAFIVLEDADIEYAVNAAV FSRFTHQGQICMSANRVLVHSSIYDKFLELYQAKVESLKVGDPMDPDTIIGPLINSRQ TDGLMKTVEQAIEEGAVPVKLGGFNGTIVEPTILKDVKPFMSIAKEELFGPVVSFMKF DSEDEAVDIANETPFGLSGAVHTSNLERGVAFAKRIETGMIHVNDTTINDEPNVAFGG EKQSGLGRLNGEWSLEEFTTLKWISVQHEKRSFPY*" /label="vdhT CDS" gene 731316..732773 /gene="vdhT" /locus_tag="BSU_07350" /old_locus_tag="BSU07350" /label="vdhT gene" promotor_-10 complement(732109..732128) /Source="Nicolas_upshift_promotors" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(732123) /Source="Nicolas_upshifts" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(732141..732150) /Source="Nicolas_upshift_promotors" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 732787..733647 /gene="yfmS" /locus_tag="BSU_07360" /old_locus_tag="BSU07360" /function="16.5: Explore" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="chemotaxis sensory transducer (sensed target unknown)" /protein_id="NP_388617.1" /db_xref="EnsemblGenomes-Gn:BSU07360" /db_xref="EnsemblGenomes-Tr:CAB12555" /db_xref="GOA:O06477" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="SubtiList:BG12970" /db_xref="UniProtKB/Swiss-Prot:O06477" /translation="MELTINTEKETADILDAFIKVAPYLNSLVQDDITIGIYDTEKLL VNIPAKTFSLNVKAGDPLQEGDIITDAIRSNQKKTSMVPKELFGFPLIARAIPLHDEN GRVIGGVGLGTSLEESSKLHDVAESLSAVVEQTAAAISDISESINGFSTQMSGISSQA KKVSESAGEIADISVTVKGISDQSNLLGLNAAIEAARAGESGKGFSVVADEIRKLATH SKENVGQIDQITKKIHSLLKGLEESIESINQHTDGQAAAVEQISATMQEISGSAQHLA KMAEKALEEE*" /label="yfmS CDS" gene 732787..733647 /gene="yfmS" /locus_tag="BSU_07360" /old_locus_tag="BSU07360" /label="yfmS gene" downshifts 733631 /Source="Nicolas_upshifts" /id="D364" /incds=0 /nref=208 /ntot=237 /MaxReadThrough="2.9987" /MaxDrop="6.02377" /score="31.9989755" /energy="-16.7" /TU="U555" /idTUdmin="U555" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 733715..733722 /Source="Nicolas_upshift_promotors" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 733736..733755 /Source="Nicolas_upshift_promotors" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 733741 /Source="Nicolas_upshifts" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="upshifts" CDS 733782..735671 /gene="ettA" /locus_tag="BSU_07370" /old_locus_tag="BSU07370" /EC_number="3.6.3.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10715006, 16109936, 18848624, 19948254, 24389465, 24389466; Product type r : regulator" /codon_start=1 /transl_table=11 /product="putative energy-dependent translational throttleA" /protein_id="NP_388618.1" /db_xref="EnsemblGenomes-Gn:BSU07370" /db_xref="EnsemblGenomes-Tr:CAB12556" /db_xref="GOA:O06476" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032524" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12969" /db_xref="UniProtKB/Swiss-Prot:O06476" /translation="MSILKAENLYKTYGDKTLFDHISFHIEENERIGLIGPNGTGKST LLKVIAGLESIEEGEITKSGSVQVEFLHQDPELPAGQTVLEHIYSGESAVMKTLREYE KALYELGKDPENEQRQKHLLAAQAKMDANNAWDANTLAKTVLSKLGVNDVTKPVNELS GGQKKRVAIAKNLIQPADLLILDEPTNHLDNETIEWLEGYLSQYPGAVMLVTHDRYFL NRVTNRIYELERGSLYTYKGNYEVFLEKRAEREAQAEQKETKRQNLLRRELAWLRRGA KARSTKQKARIDRVETLKEQTGPQSSGSLDFAIGSHRLGKQVIEAENVMIAYDGRMLV DRFNELVIPGERIGIIGPNGIGKTTLLNALAGRHTPDGGDITIGQTVRIGYYTQDHSE MNGELKVIDYIKETAEVVKTADGDMITAEQMLERFLFPRSMQQTYIRKLSGGEKRRLY LLQVLMQEPNVLFLDEPTNDLDTETLSVLEDYIDQFPGVVITVSHDRYFLDRVVDRLI VFEGNGVISRFQGSYSDYMEESKAKKAAPKPAAEEKTAEAEPKKKRKKLSYKDQLEWD GIEDKIAQLEEKHEQLEADIAAAGSDFGKIQELMAEQAKTAEELEAAMDRWTELSLMI EELES*" /label="ettA CDS" gene 733782..735671 /gene="ettA" /locus_tag="BSU_07370" /old_locus_tag="BSU07370" /label="ettA gene" downshifts 735655 /Source="Nicolas_upshifts" /id="D365" /incds=0 /nref=2 /ntot=134 /MaxReadThrough="2.98669" /MaxDrop="2.72484" /score="30.3267801" /energy="-13.8" /TU="U557" /idTUdmin="U557" /TUdmin="-572" /isTUend="FALSE" /label="downshifts" misc_feature 735735..735754 /Source="Nicolas_upshift_promotors" /id="U558" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.99000999000999" /xcortree=1625 /SigmaFactorBS="gcagcaggccgcgctttttttcacataatggacaaaaacgaa ccggcctgctTATGTTAGGATAAAGTTGTGtgtcagcggcacatggaaaactaacgga g" /listShort="yfmQ" /listLong="yfmP, yfmO" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 735743 /Source="Nicolas_upshifts" /id="U558" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.99000999000999" /xcortree=1625 /SigmaFactorBS="gcagcaggccgcgctttttttcacataatggacaaaaacgaa ccggcctgctTATGTTAGGATAAAGTTGTGtgtcagcggcacatggaaaactaacgga g" /listShort="yfmQ" /listLong="yfmP, yfmO" /label="upshifts" CDS 735794..736240 /gene="yfmQ" /locus_tag="BSU_07380" /old_locus_tag="BSU07380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 26483775" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388619.1" /db_xref="EnsemblGenomes-Gn:BSU07380" /db_xref="EnsemblGenomes-Tr:CAB12557" /db_xref="GOA:O06475" /db_xref="InterPro:IPR019723" /db_xref="SubtiList:BG12968" /db_xref="UniProtKB/Swiss-Prot:O06475" /translation="MTWAIVMLILMSLVKIVLTCLPTGVIEWLLGKFEVHAKLSDENA SLSLDGKRLEGAEKQKVIDQFNEAIFLEKYYIYPGDEERYLHPENGGTPLVIDTKKGK KDVKLFVYRYDDHIDVVKQYKKKVIAYRVLSESLQKESLSVAGSLA*" /label="yfmQ CDS" gene 735794..736240 /gene="yfmQ" /locus_tag="BSU_07380" /old_locus_tag="BSU07380" /label="yfmQ gene" downshifts complement(735796) /Source="Nicolas_upshifts" /id="D366" /incds=0 /nref=48 /ntot=154 /MaxReadThrough="1.16717" /MaxDrop="4.57866" /score="0.689181271" /energy="-10.2" /TU="NA" /idTUdmin="U559" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(735880..735883) /Source="Nicolas_upshift_promotors" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(735885) /Source="Nicolas_upshifts" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(735901..735902) /Source="Nicolas_upshift_promotors" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 736227 /Source="Nicolas_upshifts" /id="D367" /incds=0 /nref=254 /ntot=267 /MaxReadThrough="3.12706" /MaxDrop="7.87026" /score="13.6774886" /energy="-8" /TU="U558" /idTUdmin="U557" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 736303..736310 /Source="Nicolas_upshift_promotors" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 736324..736343 /Source="Nicolas_upshift_promotors" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 736336 /Source="Nicolas_upshifts" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="upshifts" CDS 736365..736787 /gene="copP" /locus_tag="BSU_07390" /old_locus_tag="BSU07390" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MerR family) of metal(copper) efflux transporter expression" /protein_id="NP_388620.1" /db_xref="EnsemblGenomes-Gn:BSU07390" /db_xref="EnsemblGenomes-Tr:CAB12558" /db_xref="GOA:O06474" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG12967" /db_xref="UniProtKB/Swiss-Prot:O06474" /translation="MEWMKIDQVAKRSGLTKRTIRFYEEIGLIPAPKRTDGGVRLYSE DDMEELEKVISTKEVLGFSLQELQHFMETSRQLELNKEGYLLSLDPKERKEKLEEIQE TLNHQLDLIDEKIRTFQSFKERLQGMKGKAERAIQSIE*" /label="copP CDS" gene 736365..736787 /gene="copP" /locus_tag="BSU_07390" /old_locus_tag="BSU07390" /label="copP gene" downshifts 736623 /Source="Nicolas_upshifts" /id="D368" /incds=1 /nref=2 /ntot=135 /MaxReadThrough="4.24358" /MaxDrop="2.69696" /score="13.6774886" /energy="-8" /TU="U560" /idTUdmin="U558" /TUdmin=308 /isTUend="FALSE" /label="downshifts" CDS 736853..738043 /gene="copO" /locus_tag="BSU_07400" /old_locus_tag="BSU07400" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14663075, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="metal (copper) efflux transporter" /protein_id="NP_388621.1" /db_xref="EnsemblGenomes-Gn:BSU07400" /db_xref="EnsemblGenomes-Tr:CAB12559" /db_xref="GOA:O06473" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12966" /db_xref="UniProtKB/Swiss-Prot:O06473" /translation="MDKTTQVNQKTGLLSQPKAVWAVAFACVISFMGIGLVDPILPAI AAQLHASPSEVSLLFTSYLLVTGFMMFFSGAISSRIGAKWTLILGLIFIIVFAGLGGS SSSIAQLVGYRGGWGLGNALFISTALAVIVGVSVGGSAQAIILYEAALGLGISVGPLA GGELGSISWRAPFFGVSVLMFIALIAISFMLPKLPKPAKRVGVFDAMKALKYKGLLTM AVSAFLYNFGFFILLAYSPFVLDLDEHGLGYVFFGWGLLLAITSVFTAPLVHKALGTV RSLVVLFIAFAAILVIMGIWTDHQTLIITCIVVAGAVLGMVNTIMTTAVMGSAPVERS IASSAYSSVRFIGGALAPWIAGMLSEHFTASTPYTVGGIVVFVGMLVLLMGRKHLAGI KAGH*" /label="copO CDS" gene 736853..738043 /gene="copO" /locus_tag="BSU_07400" /old_locus_tag="BSU07400" /label="copO gene" downshifts complement(738107) /Source="Nicolas_upshifts" /id="D369" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="-0.0437700000000003" /MaxDrop="2.92105" /score="-8.93016606" /energy="-11.6" /TU="NA" /idTUdmin="U562" /TUdmin=528 /isTUend="FALSE" /label="downshifts" CDS 738334..738489 /gene="yfmN" /locus_tag="BSU_07410" /old_locus_tag="BSU07410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388622.1" /db_xref="EnsemblGenomes-Gn:BSU07410" /db_xref="EnsemblGenomes-Tr:CAB12560" /db_xref="SubtiList:BG12965" /db_xref="UniProtKB/Swiss-Prot:O06472" /translation="MDKAKPDEYDQKCLETLYQYIHSVMKNSFSRSSGLPLGKMRRIL SCLPKES*" /label="yfmN CDS" gene 738334..738489 /gene="yfmN" /locus_tag="BSU_07410" /old_locus_tag="BSU07410" /label="yfmN gene" CDS complement(738609..740165) /gene="ettM" /locus_tag="BSU_07420" /old_locus_tag="BSU07420" /EC_number="3.6.3.-" /function="16.7: Manage energy" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040, 16109936, 16684363, 22333191, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_388623.2" /db_xref="EnsemblGenomes-Gn:BSU07420" /db_xref="EnsemblGenomes-Tr:CAB12571" /db_xref="GOA:O34512" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12964" /db_xref="UniProtKB/Swiss-Prot:O34512" /translation="MSILSVKDLSHGFGDRAIFNNVSFRLLKGEHVGLIGANGEGKST FMNIITGKLEPDEGKVEWSKNVRVGYLDQHTVLEKGKSIRDVLKDAFHYLFAMEEEMN EIYNKMGEADPDELEKLLEEVGVIQDALTNNDFYVIDSKVEEIARGLGLSDIGLERDV TDLSGGQRTKVLLAKLLLEKPEILLLDEPTNYLDEQHIEWLKRYLQEYENAFILISHD IPFLNSVINLIYHVENQELTRYVGDYHQFMEVYEVKKQQLEAAYKKQQQEVAELKDFV ARNKARVSTRNMAMSRQKKLDKMDMIELAAEKPKPEFHFKPARTSGKLIFETKDLVIG YDSPLSRPLNLRMERGQKIALYGANGIGKTTLLKSLLGEIQPLEGSVERGEHIYTGYF EQEVKETNNNTCIEEVWSEFPSYTQYEIRAALAKCGLTTKHIESRVSVLSGGEKAKVR LCKLINSETNLLVLDEPTNHLDADAKEELKRALKEYKGSILLISHEPDFYMDIATETW NCESWTTKVL*" /label="ettM CDS" gene complement(738609..740165) /gene="ettM" /locus_tag="BSU_07420" /old_locus_tag="BSU07420" /label="ettM gene" downshifts complement(738633) /Source="Nicolas_upshifts" /id="D370" /incds=0 /nref=173 /ntot=264 /MaxReadThrough="0.35675" /MaxDrop="5.82627" /score="21.7805812" /energy="-12" /TU="NA" /idTUdmin="U562" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 739995..740001 /Source="Nicolas_upshift_promotors" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 740016..740027 /Source="Nicolas_upshift_promotors" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 740033 /Source="Nicolas_upshifts" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(740215..740234) /Source="Nicolas_upshift_promotors" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(740219) /Source="Nicolas_upshifts" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(740250..740254) /Source="Nicolas_upshift_promotors" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 740275..740278 /Source="Nicolas_upshift_promotors" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 740294..740313 /Source="Nicolas_upshift_promotors" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 740297 /Source="Nicolas_upshifts" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="upshifts" CDS 740338..741468 /gene="yfmL" /locus_tag="BSU_07430" /old_locus_tag="BSU07430" /EC_number="3.6.1.-" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11976317; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent RNA helicase" /protein_id="NP_388624.1" /db_xref="EnsemblGenomes-Gn:BSU07430" /db_xref="EnsemblGenomes-Tr:CAB12572" /db_xref="GOA:O34750" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12963" /db_xref="UniProtKB/Swiss-Prot:O34750" /translation="MTQTWPFLHNAQSFIQENWNASGFQKPTPVQEQAAQLIMDGKDV IAESPTGTGKTLAYALPVLERIKPEQKHPQAVILAPSRELVMQIFQVIQDWKAGSELR AASLIGGANVKKQVEKLKKHPHIIVGTPGRVFELIKAKKLKMHEVKTIVLDETDQLVL PEHRETMKQIIKTTLRDRQLLCFSATLKKETEDVLRELAQEPEVLKVQRSKAEAGKVK HQYLICDQRDKVKLLQKLSRLEGMQALVFVRDIGNLSVYAEKLAYHHVELGVLHSEAK KMERAKIIATFEDGEFPLLLATDIAARGLDIENLPYVIHADIPDEDGYVHRSGRTGRA GKEGNVLSLVTKLEESKLKKMAKKLGVELSEAVYAGGKLKTK*" /label="yfmL CDS" gene 740338..741468 /gene="yfmL" /locus_tag="BSU_07430" /old_locus_tag="BSU07430" /label="yfmL gene" downshifts 741451 /Source="Nicolas_upshifts" /id="D371" /incds=0 /nref=43 /ntot=133 /MaxReadThrough="2.93747" /MaxDrop="4.41385" /score="23.4253604" /energy="-5.9" /TU="NA" /idTUdmin="U563" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" CDS 741536..741982 /gene="yfmK" /locus_tag="BSU_07440" /old_locus_tag="BSU07440" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388625.1" /db_xref="EnsemblGenomes-Gn:BSU07440" /db_xref="EnsemblGenomes-Tr:CAB12573" /db_xref="GOA:O34536" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12962" /db_xref="UniProtKB/Swiss-Prot:O34536" /translation="MASIDRFQVMQEPELKILEHWFENEDTRRRMDGMLLLDEWYARV NKDKHDTVIMAYDGQLPAGMVVIEFGEERTYIGLIVNPLYRLKGYGKQILQKLMTEPD FTSVREWVACIEEDNRISLACFQAAGFTLEDTEPDEDGFLTLILRN*" /label="yfmK CDS" gene 741536..741982 /gene="yfmK" /locus_tag="BSU_07440" /old_locus_tag="BSU07440" /label="yfmK gene" CDS complement(742035..743054) /gene="yfmJ" /locus_tag="BSU_07450" /old_locus_tag="BSU07450" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388626.1" /db_xref="EnsemblGenomes-Gn:BSU07450" /db_xref="EnsemblGenomes-Tr:CAB12574" /db_xref="GOA:O34812" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12961" /db_xref="UniProtKB/Swiss-Prot:O34812" /translation="MTASQQQIQLARRPQGIPVHEDFRFETIPVPEPKQGEVLVKTLY VSVDPYMRGRMQDTKSYVEPFALDKALSGGVIAEVVSDGNHLKKGDIVIGNLSWQEFS AVSESALRKIDTSLAPASAYLGILGMTGLTAYFGLLDIGRPKEGETVVVSGAAGAVGS TVGQIAKIKGARVVGIAGSDEKIDYLKQELQFDEAINYKTADDIQKALQNACPDGVDV YFDNVGGPISDAVMNLLNEFARIPVCGAISSYNAESEADDMGPRVQSKLIKTKSLMQG FIVSDYSDRFSEGAKQLAEWLKAGKLHYEETITEGFENIPDAFLGLFKGENKGKQLIK VSDPS*" /label="yfmJ CDS" gene complement(742035..743054) /gene="yfmJ" /locus_tag="BSU_07450" /old_locus_tag="BSU07450" /label="yfmJ gene" downshifts complement(742045) /Source="Nicolas_upshifts" /id="D372" /incds=0 /nref=183 /ntot=252 /MaxReadThrough="2.26899" /MaxDrop="5.73395" /score="20.8047206" /energy="-12.8" /TU="NA" /idTUdmin="U564" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(743075..743094) /Source="Nicolas_upshift_promotors" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(743079) /Source="Nicolas_upshifts" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(743081..743535) /Source="Nicolas_S_feature" /locus_tag="new_818856_819310_c" /HighExp="S2, S1, Pyr, T4.0H, T0.0H, T-2.40H, T3.30H, T-1.40H, T-0.40H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S252" promotor_-35 complement(743107..743114) /Source="Nicolas_upshift_promotors" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 743173..743180 /Source="Nicolas_upshift_promotors" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 743194..743213 /Source="Nicolas_upshift_promotors" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 743201..744298 /Source="Nicolas_S_feature" /locus_tag="new_818976_820073" /HighExp="Etha, dia5, Diami, C30, dia15, T5.0H, S8, T3.0H, M0t90, LPhT" /AntisenseName="yfmI" /AntisenseCor="0.135213889213362" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S253" upshifts 743201 /Source="Nicolas_upshifts" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="upshifts" CDS complement(743536..744756) /gene="yfmI" /locus_tag="BSU_07460" /old_locus_tag="BSU07460" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388627.1" /db_xref="EnsemblGenomes-Gn:BSU07460" /db_xref="EnsemblGenomes-Tr:CAB12575" /db_xref="GOA:O34440" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12960" /db_xref="UniProtKB/Swiss-Prot:O34440" /translation="MSKGYYSILFSQTTTNLGFSLYTMVVISFLFKMTNSTTIASMVT LISIIFRIFGSAILPLITIRLKLPLTIIISQLIQMLLLICLFYALLRTYSNQTLILVF IIISCISFFNGWFSPLKSAIIGEIISPDRRVKANGLLSTVDQTFQFVGWSLGGLIIAF LGEGYTIILTIFLLFTSLLSLLFCLPHGHANSVIREKNSPNKSIVSGWRYLFSQKKLR TIIIMDLIESWAGMIWIGSVSLAFVNEVLHKGESWWGFINGAYYLGSMIGGFIIYKLS ERFQNKLINFMLIGAVSYGSLTLIYGFISNSYLALILVLFMGPAYILRDLTQETLIQN ITTEQTRINIMSARSSLVQFIFMFSILAIGAISDFLGVRLVYVSAGILLLVSAIYGFS QLQFKKKVNKHISF*" /label="yfmI CDS" gene complement(743536..744756) /gene="yfmI" /locus_tag="BSU_07460" /old_locus_tag="BSU07460" /label="yfmI gene" promotor_-10 complement(744793..744812) /Source="Nicolas_upshift_promotors" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(744800) /Source="Nicolas_upshifts" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(744828..744835) /Source="Nicolas_upshift_promotors" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 744854..744861 /Source="Nicolas_upshift_promotors" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 744873..745048 /Source="Nicolas_S_feature" /locus_tag="new_820648_820823" /HighExp="LoTm, T-1.10H, T-0.40H, S3, M9-stat, T0.0H, T-1.40H, BC, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.98260400000000003" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S254" upshifts 744873 /Source="Nicolas_upshifts" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 744876..744895 /Source="Nicolas_upshift_promotors" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 745005 /Source="Nicolas_upshifts" /id="D373" /incds=0 /nref=34 /ntot=117 /MaxReadThrough="8.67835" /MaxDrop="8.45742" /score="4.02328636" /energy="-13.7" /TU="U567" /idTUdmin="U565" /TUdmin=748 /isTUend="FALSE" /label="downshifts" CDS 745092..746555 /gene="yfmG" /locus_tag="BSU_07480" /old_locus_tag="BSU07480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388629.1" /db_xref="EnsemblGenomes-Gn:BSU07480" /db_xref="EnsemblGenomes-Tr:CAB12577" /db_xref="InterPro:IPR005532" /db_xref="InterPro:IPR016187" /db_xref="SubtiList:BG12958" /db_xref="UniProtKB/Swiss-Prot:O34722" /translation="MTLLMQDHKSIYNKDIEILIEVEELITSVPENKKNDFKSLIDNR IMTLLNKIQHPVAAENVFGMCIAYPNTYIRYRLIDFVEKWVPYFSAVETIINLTQDPD DLVSFKAMDVCANHKIEESVAYLSSIIDDVRESISYPKKPVGLGAQKVLSTLLDIFGV EKHEELVMLKNYFDQNGILPNNFDFEEKIPQSLIEEFEKTEEDGMILIPGGFFEFGLN ENEIPDKTFNWKDAVPRQKVWLPPFFIDKYPVTNKDYDIFTEFIEENGHIFCHPNEPQ NKQHRRNTYWDDRYLDNHPVTGIDFYDAFAYARYKGKELPTEFQWEKAARGEKGNVWP WGDKFDPAKVQYAGSLYNEPITSLKSWRENLLKAHADKELNHLTSDIFEQNGESPYGV CGMIGGTWEWTRSELKTKRAFHPIFENVPFNSVNSFAVLKGGSFFSHPGLMFPSFRAK DIPFCRHNEMGIRCVKNIPVYKIRESINGPITNKAIY*" /label="yfmG CDS" gene 745092..746555 /gene="yfmG" /locus_tag="BSU_07480" /old_locus_tag="BSU07480" /label="yfmG gene" S_feature complement(745457..747127) /Source="Nicolas_S_feature" /locus_tag="new_821232_822902_c" /HighExp="H2O2, C30, Salt, Lbstat, dia15, LPhT, dia5, Paraq, HiOs, Diami" /AntisenseName="yfmG" /AntisenseCor="-0.58045119682782798" /AntisenseRegPval="-24.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S255" S_feature 746556..747049 /Source="Nicolas_S_feature" /locus_tag="new_822331_822824" /HighExp="LoTm, T0.0H, T-1.40H, T-0.40H, T-2.40H, T-1.10H, Pyr, T-3.40H, SMMPr, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S256" promotor_-35 747037..747042 /Source="Nicolas_upshift_promotors" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 747051..750316 /Source="Nicolas_S_feature" /locus_tag="new_822826_826091" /HighExp="LoTm, Pyr, B36, T3.30H, T2.0H, T-0.40H, T2.30H, B60, T4.0H, T3.0H" /AntisenseName="yfmE" /AntisenseCor="-0.61640022790163695" /AntisenseRegPval="-28.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.982, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S257" upshifts 747051 /Source="Nicolas_upshifts" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 747058..747076 /Source="Nicolas_upshift_promotors" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(747128..747928) /gene="fecF" /locus_tag="BSU_07490" /old_locus_tag="BSU07490" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16672620, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16672620, 22194458; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (ATP-binding protein)" /protein_id="NP_388630.1" /db_xref="EnsemblGenomes-Gn:BSU07490" /db_xref="EnsemblGenomes-Tr:CAB12578" /db_xref="GOA:O34510" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12957" /db_xref="UniProtKB/Swiss-Prot:O34510" /translation="MGKLAADQLTLSYDSTVIIDGVDLKIEEGKITALIGANGCGKST ILKSLARLMAPKSGTVLLEGKDIHRQPSKEVAKKLAILPQSPQAPEGLTVEELCYFGR HPHKKLLSKHTQEDHDMVEWALEATGMIELKDRTLDALSGGQRQRAWISMALAQGTDL LLLDEPTTYLDISHQIEVLELLKKLNRDHGRTVVMVLHDLNQAAQYADYLISVLDGKI YNAGTPEDVFTQPFFREVFGLECCIMRSPIDQKPMCLPTGLCPKLRAK*" /label="fecF CDS" gene complement(747128..747928) /gene="fecF" /locus_tag="BSU_07490" /old_locus_tag="BSU07490" /label="fecF gene" CDS complement(747941..748942) /gene="fecE" /locus_tag="BSU_07500" /old_locus_tag="BSU07500" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16672620, 16850406, 22194458; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (permease)" /protein_id="NP_388631.1" /db_xref="EnsemblGenomes-Gn:BSU07500" /db_xref="EnsemblGenomes-Tr:CAB12579" /db_xref="GOA:O34832" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12956" /db_xref="UniProtKB/Swiss-Prot:O34832" /translation="MKKTTRKQKRPLLAILILAVILIVLSVISIGIGALYISPDAVVT NLLGLDHSFEFIIQQYRLPRIILAILAGAGLAAAGAILQGVIRNPLASPDVVGISKGS GLAAMAVILIFPESPVYVLPFSAFAGAAIIAVLLLMIARKKSIQPSSLALSGIALGAV CHAGMQYMMVKFPGDVNAALIWLTGSLWGRNWEEVKLLAPWLLILFPIVCILIPKLDL MSLGDELAQGLGENANRLRFILIFTAVALAGSCVAVVGSIGFIGLLAPHIARRLTGEK AKYLLPASALIGAIILLIADTLGRGIMPPVEIPAGILTAVIGAPYFLYLLKFEARKQ* " /label="fecE CDS" gene complement(747941..748942) /gene="fecE" /locus_tag="BSU_07500" /old_locus_tag="BSU07500" /label="fecE gene" promotor_-10 complement(748528..748547) /Source="Nicolas_upshift_promotors" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(748540) /Source="Nicolas_upshifts" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(748562..748569) /Source="Nicolas_upshift_promotors" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(748939..749940) /gene="fecD" /locus_tag="BSU_07510" /old_locus_tag="BSU07510" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 22194458; Product type t : transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (permease)" /protein_id="NP_388632.1" /db_xref="EnsemblGenomes-Gn:BSU07510" /db_xref="EnsemblGenomes-Tr:CAB12580" /db_xref="GOA:O34933" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12955" /db_xref="UniProtKB/Swiss-Prot:O34933" /translation="MYHSAKRRSSSRLMMFIIALIIFIFGLGLNLSVGASDISIIDSL KYLFVWDGSKEQLIISTLRLPRTLIGVFVGASLAVAGALMQAMTRNPLASPQIFGVNA GASLFVVASLVILPASPYSSVIFAFAGAAAGGAIVYMIASSGGMTPVKLALSGMAVHL FLSSMTQAIIILNESGEDVLYWMTGAIDGSNWQDVITIAPFSVIGIGLALVFSGSVSV LGLGDETAKGLGQNMNGIRILISLIILILSGASVAVAGPIGFVGLLVPHIVRKLIGEH YQYVLPFSALFGAILLVYADVLARWIAFPYESPVGIVTAIIGTPFFLYLARKGRNLK* " /label="fecD CDS" gene complement(748939..749940) /gene="fecD" /locus_tag="BSU_07510" /old_locus_tag="BSU07510" /label="fecD gene" misc_feature complement(750010..750029) /Source="Nicolas_upshift_promotors" /id="U570" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.664335664335664" /psig="0.701298701298701" /xcortree=1492 /SigmaFactorBS="acacttggacaagattcagaggcatcaagtctagtgaaacaa gcgccaaagatgtgcttaaaAAAGTGTATAATAAATAGGAcaaatgagaagcgagggg a" /listShort="yfmD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(750012..750959) /gene="fecC" /locus_tag="BSU_07520" /old_locus_tag="BSU07520" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 22194458; Product type t : transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (binding lipoprotein)" /protein_id="NP_388633.1" /db_xref="EnsemblGenomes-Gn:BSU07520" /db_xref="EnsemblGenomes-Tr:CAB12581" /db_xref="GOA:O34348" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG12954" /db_xref="UniProtKB/Swiss-Prot:O34348" /translation="MRTYSNKLIAIMSVLLLACLIVSGCSSSQNNNGSGKSESKDSRV IHDEEGKTTVSGTPKRVVVLELSFLDAVHNLGITPVGIADDNKKDMIKKLVGSSIDYT SVGTRSEPNLEVISSLKPDLIIADAERHKNIYKQLKKIAPTIELKSREATYDETIDSF TTIAKALNKEDEGKEKLAEHKKVINDLKAELPKDENRNIVLGVARADSFQLHTSSSYD GEIFKMLGFTHAVKSDNAYQEVSLEQLSKIDPDILFISANEGKTIVDEWKTNPLWKNL KAVKNGQVYDADRDTWTRFRGIKSSETSAKDVLKKVYNK*" /label="fecC CDS" gene complement(750012..750959) /gene="fecC" /locus_tag="BSU_07520" /old_locus_tag="BSU07520" /label="fecC gene" downshifts complement(750031) /Source="Nicolas_upshifts" /id="D374" /incds=0 /nref=41 /ntot=211 /MaxReadThrough="4.92983" /MaxDrop="4.53674" /score="-3.64310934" /energy="-13.9" /TU="U570,U573,U574" /idTUdmin="U570" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" upshifts complement(750031) /Source="Nicolas_upshifts" /id="U570" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.664335664335664" /psig="0.701298701298701" /xcortree=1492 /SigmaFactorBS="acacttggacaagattcagaggcatcaagtctagtgaaacaa gcgccaaagatgtgcttaaaAAAGTGTATAATAAATAGGAcaaatgagaagcgagggg a" /listShort="yfmD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 750286..750291 /Source="Nicolas_upshift_promotors" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 750307..750325 /Source="Nicolas_upshift_promotors" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 750318..750943 /Source="Nicolas_S_feature" /locus_tag="new_826093_826718" /HighExp="LoTm, B36, S5, S6, S4, S7, S8, S3, BT, B60" /AntisenseName="yfmC" /AntisenseCor="-0.52042999587715499" /AntisenseRegPval="-19.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S258" upshifts 750318 /Source="Nicolas_upshifts" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="upshifts" misc_feature 750939..750958 /Source="Nicolas_upshift_promotors" /id="U572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.905094905094905" /psig="0.997002997002997" /xcortree=1855 /SigmaFactorBS="acagccggatacaatgaggcaggcgagcaataaaacactcat gatggcaatcaaCTTGTTAGAATAGGTGCGCAtgtcattcttccttttttcagattta g" /listShort="S259" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 750945..751476 /Source="Nicolas_S_feature" /locus_tag="new_826720_827251" /HighExp="LoTm, B36, S5, S4, S7, S6, S8, B60, S3, BT" /AntisenseName="yfmB" /AntisenseCor="-6.4915194654100006E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigA" /TUshortPSig="0.997, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S259" upshifts 750945 /Source="Nicolas_upshifts" /id="U572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.905094905094905" /psig="0.997002997002997" /xcortree=1855 /SigmaFactorBS="acagccggatacaatgaggcaggcgagcaataaaacactcat gatggcaatcaaCTTGTTAGAATAGGTGCGCAtgtcattcttccttttttcagattta g" /listShort="S259" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(751001..751020) /Source="Nicolas_upshift_promotors" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(751008) /Source="Nicolas_upshifts" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(751034..751041) /Source="Nicolas_upshift_promotors" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(751068..751436) /gene="yfmB" /locus_tag="BSU_07530" /old_locus_tag="BSU07530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25651892" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388634.1" /db_xref="EnsemblGenomes-Gn:BSU07530" /db_xref="EnsemblGenomes-Tr:CAB12582" /db_xref="InterPro:IPR021579" /db_xref="PDB:2EUC" /db_xref="SubtiList:BG12953" /db_xref="UniProtKB/Swiss-Prot:O34626" /translation="MQYFSPEQQYNAWIVSDLVKQIFHKRAGCSPGIHELAVFAEEHF HIDIDFVFSIIMNIGDIEFALTDEIEKKLSGYLSTLLPYVTADMFETSKANAHAFLSR RHGNAAYHLFVSDDAFMRKQ*" /label="yfmB CDS" gene complement(751068..751436) /gene="yfmB" /locus_tag="BSU_07530" /old_locus_tag="BSU07530" /label="yfmB gene" S_feature complement(751437..751549) /Source="Nicolas_S_feature" /locus_tag="new_827212_827324_c" /HighExp="Etha, BC, Sw, M9-stat, T3.30H, T1.30H, T3.0H, T5.0H, T2.30H, T2.0H" /AntisenseName="yfmA" /AntisenseCor="5.8024036419347599E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S260" promotor_-10 complement(751538..751557) /Source="Nicolas_upshift_promotors" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="promotor_-10" upshifts complement(751549) /Source="Nicolas_upshifts" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="upshifts" promotor_-35 complement(751569..751576) /Source="Nicolas_upshift_promotors" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="promotor_-35" promotor_-35 751617..751623 /Source="Nicolas_upshift_promotors" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 751637..751655 /Source="Nicolas_upshift_promotors" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 751637 /Source="Nicolas_upshifts" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="upshifts" CDS 751680..752027 /gene="yflT" /locus_tag="BSU_07550" /old_locus_tag="BSU07550" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12089032; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heat stress induced protein" /protein_id="NP_388636.1" /db_xref="EnsemblGenomes-Gn:BSU07550" /db_xref="EnsemblGenomes-Tr:CAB12584" /db_xref="InterPro:IPR025889" /db_xref="SubtiList:BG19020" /db_xref="UniProtKB/Swiss-Prot:P80241" /translation="MKPVVKEYTNDEQLMKDVEELQKMGVAKEDVYVLAHDDDRTERL ADNTNANTIGAKETGFKHAVGNIFNKKGDELRNKIHEIGFSEDEAAQFEKRLDEGKVL LFVTDNEKVKAWA*" /label="yflT CDS" gene 751680..752027 /gene="yflT" /locus_tag="BSU_07550" /old_locus_tag="BSU07550" /label="yflT gene" downshifts complement(751681) /Source="Nicolas_upshifts" /id="D375" /incds=0 /nref=6 /ntot=28 /MaxReadThrough="1.00082" /MaxDrop="4.87687" /score="-3.31058364" /energy="-3.6" /TU="NA" /idTUdmin="U570" /TUdmin="-1848" /isTUend="FALSE" /label="downshifts" downshifts 752023 /Source="Nicolas_upshifts" /id="D376" /incds=0 /nref=56 /ntot=197 /MaxReadThrough="6.41566" /MaxDrop="7.61596" /score="-1.88723414" /energy="-5.6" /TU="U575" /idTUdmin="U567" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 752068..752148 /Source="Nicolas_S_feature" /locus_tag="new_827843_827923" /HighExp="Etha, Salt, B36, LoTm, Heat, B60, M9-stat, S8, C30, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S261" misc_feature 752149..752168 /Source="Nicolas_upshift_promotors" /id="U576" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.972027972027972" /xcortree=3242 /SigmaFactorBS="gattttgcagaatgccgcaataggatagcggaacattttcgg ttctgaatgtccctcaaTTTGCTATTATATTTTTGTGataaattggaataaaatctca c" /listShort="pel" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 752150 /Source="Nicolas_upshifts" /id="U576" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.972027972027972" /xcortree=3242 /SigmaFactorBS="gattttgcagaatgccgcaataggatagcggaacattttcgg ttctgaatgtccctcaaTTTGCTATTATATTTTTGTGataaattggaataaaatctca c" /listShort="pel" /GFF_Attribute="listLong" /label="upshifts" CDS 752218..753480 /gene="pelA" /locus_tag="BSU_07560" /old_locus_tag="BSU07560" /EC_number="4.2.2.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8262178, 12823818, 27447541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8262178, 12823818, 27447541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pectate lyase" /protein_id="NP_388637.1" /db_xref="EnsemblGenomes-Gn:BSU07560" /db_xref="EnsemblGenomes-Tr:CAB12585" /db_xref="GOA:P39116" /db_xref="InterPro:IPR002022" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="PDB:1BN8" /db_xref="PDB:2BSP" /db_xref="PDB:2NZM" /db_xref="PDB:2O04" /db_xref="PDB:2O0V" /db_xref="PDB:2O0W" /db_xref="PDB:2O17" /db_xref="PDB:2O1D" /db_xref="PDB:3KRG" /db_xref="PDB:5AMV" /db_xref="SubtiList:BG10840" /db_xref="UniProtKB/Swiss-Prot:P39116" /translation="MKKVMLATALFLGLTPAGANAADLGHQTLGSNDGWGAYSTGTTG GSKASSSNVYTVSNRNQLVSALGKETNTTPKIIYIKGTIDMNVDDNLKPLGLNDYKDP EYDLDKYLKAYDPSTWGKKEPSGTQEEARARSQKNQKARVMVDIPANTTIVGSGTNAK VVGGNFQIKSDNVIIRNIEFQDAYDYFPQWDPTDGSSGNWNSQYDNITINGGTHIWID HCTFNDGSRPDSTSPKYYGRKYQHHDGQTDASNGANYITMSYNYYHDHDKSSIFGSSD SKTSDDGKLKITLHHNRYKNIVQRAPRVRFGQVHVYNNYYEGSTSSSSYPFSYAWGIG KSSKIYAQNNVIDVPGLSAAKTISVFSGGTALYDSGTLLNGTQINASAANGLSSSVGW TPSLHGSIDASANVKSNVINQAGAGKLN*" /label="pelA CDS" gene 752218..753480 /gene="pelA" /locus_tag="BSU_07560" /old_locus_tag="BSU07560" /label="pelA gene" downshifts 753475 /Source="Nicolas_upshifts" /id="D377" /incds=0 /nref=139 /ntot=203 /MaxReadThrough="3.61256" /MaxDrop="5.92635" /score="1.82127533" /energy="-8.2" /TU="U575,U576" /idTUdmin="U576" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" promotor_-35 753533..753536 /Source="Nicolas_upshift_promotors" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 753551..753570 /Source="Nicolas_upshift_promotors" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 753559 /Source="Nicolas_upshifts" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="upshifts" CDS 753607..755043 /gene="maeS" /locus_tag="BSU_07570" /old_locus_tag="BSU07570" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12949159, 15849754, 16850406, 25651892, 28436820" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12949159, 15849754, 16850406, 25651892, 28436820; Product type t : transporter" /codon_start=1 /transl_table=11 /product="malate (2-oxoglutarate) transporter" /protein_id="NP_388638.1" /db_xref="EnsemblGenomes-Gn:BSU07570" /db_xref="EnsemblGenomes-Tr:CAB12586" /db_xref="GOA:O34726" /db_xref="InterPro:IPR001898" /db_xref="InterPro:IPR030676" /db_xref="SubtiList:BG12951" /db_xref="UniProtKB/Swiss-Prot:O34726" /translation="MASEKDAGKQSAVKLVPLLITVAVGLIIWFIPAPSGLEPKAWHL FAIFVATIIGFISKPLPMGAIAIFALAVTALTGTLSIEDTLSGFGNKTIWLIVIAFFI SRGFIKTGLGARISYVFVQKFGKKTLGLSYSLLFSDLILSPAIPSNTARAGGIIFPII RSLSETFGSSPANGTERKIGAFLLKTGFQGNLITSAMFLTAMAANPLIAKLAHDVAGV DLTWTSWAIAAIVPGLVSLIITPLVIYKLYPPEIKETPDAAKIATEKLKEMGPFKKSE LSMVIVFLLVLVLWIFGGSFNIDATTTALIGLAVLLLSQVLTWDDIKKEQGAWDTLTW FAALVMLANFLNELGMVSWFSNAMKSSVSGFSWIVAFIILIVVYYYSHYFFASATAHI SAMYSAFLAVVVAAGAPPLLAALSLAFISNLFGSTTHYGSGAAPVFFGAGYIPQGKWW SIGFILSIVHIIVWLVIGGLWWKVLGIW*" /label="maeS CDS" gene 753607..755043 /gene="maeS" /locus_tag="BSU_07570" /old_locus_tag="BSU07570" /label="maeS gene" downshifts 755035 /Source="Nicolas_upshifts" /id="D378" /incds=0 /nref=56 /ntot=132 /MaxReadThrough="2.39993" /MaxDrop="5.36125" /score="40.3051497" /energy="-9.7" /TU="NA" /idTUdmin="U577" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" misc_feature 755134..755153 /Source="Nicolas_upshift_promotors" /id="U578" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2939 /SigmaFactorBS="tccttcgtaagaaaatggattttgaaaaatgagaaaattccc tgtgaaaAATGGTATGATCTAGGTAGAaaggacggctggtgctgtggtgaaaaagcgg t" /listShort="citS, citT, yflP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 755145 /Source="Nicolas_upshifts" /id="U578" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2939 /SigmaFactorBS="tccttcgtaagaaaatggattttgaaaaatgagaaaattccc tgtgaaaAATGGTATGATCTAGGTAGAaaggacggctggtgctgtggtgaaaaagcgg t" /listShort="citS, citT, yflP" /GFF_Attribute="listLong" /label="upshifts" CDS 755170..756798 /gene="citS" /locus_tag="BSU_07580" /old_locus_tag="BSU07580" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10972810, 11717295, 12949159, 16842348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972810, 11717295, 12949159, 16842348; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_388639.1" /db_xref="EnsemblGenomes-Gn:BSU07580" /db_xref="EnsemblGenomes-Tr:CAB12587" /db_xref="GOA:O34427" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12576" /db_xref="UniProtKB/Swiss-Prot:O34427" /translation="MVKKRFHFSLQTKIMGLIAALLVFVIGVLTITLAVQHTQGERRQ AEQLAVQTARTISYMPPVKELIERKDGHAAQTQEVIEQMKEQTGAFAIYVLNEKGDIR SASGKSGLKKLERSREILFGGSHVSETKADGRRVIRGSAPIIKEQKGYSQVIGSVSVD FLQTETEQSIKKHLRNLSVIAVLVLLLGFIGAAVLAKSIRKDTLGLEPHEIAALYRER NAMLFAIREGIIATNREGVVTMMNVSAAEMLKLPEPVIHLPIDDVMPGAGLMSVLEKG EMLPNQEVSVNDQVFIINTKVMNQGGQAYGIVVSFREKTELKKLIDTLTEVRKYSEDL RAQTHEFSNKLYAILGLLELGEYDEAIDLIKEEYAIQNEQHDLLFHNIHSQQVQAILL GKISKASEKKVKLVIDENSSLAPLPAHIGLSHLITIIGNLIDNAFEAVAEQSVKEVLF FITDMGHDIVIEVSDTGPGVPPEKIEAVFERGYSSKGMRRGYGLANVKDSVRELGGWI ELANQKTGGAVFTVFIPKEKQRGNPFDSHRDCGG*" /label="citS CDS" gene 755170..756798 /gene="citS" /locus_tag="BSU_07580" /old_locus_tag="BSU07580" /label="citS gene" CDS 756770..757450 /gene="citT" /locus_tag="BSU_07590" /old_locus_tag="BSU07590" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972810, 11717295, 12949159, 16842348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972810, 11717295, 12949159, 16842348; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_388640.1" /db_xref="EnsemblGenomes-Gn:BSU07590" /db_xref="EnsemblGenomes-Tr:CAB12588" /db_xref="GOA:O34534" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR028141" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12577" /db_xref="UniProtKB/Swiss-Prot:O34534" /translation="MIHIAIAEDDFRVAQIHERLIKQLDGFKIIGKAANAKETLALLK EHKADLLLLDIYMPDELGTALIPDIRSRFPEVDIMIITAATETRHLQEALRAGIAHYL IKPVTADKFRQVLLQYKEKRKLLMSQPEVSQSMIDHIFGNGVKTALPAEDLPTGINSI TLRKIKEALQTASEGLTAEELGEKMGASRTTARRYAEYLVSKEEARAELEYGIIGRPE RKYYLAAD*" /label="citT CDS" gene 756770..757450 /gene="citT" /locus_tag="BSU_07590" /old_locus_tag="BSU07590" /label="citT gene" CDS 757453..758412 /gene="yflP" /locus_tag="BSU_07600" /old_locus_tag="BSU07600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11029430; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative tricarboxylate transporter component" /protein_id="NP_388641.2" /db_xref="EnsemblGenomes-Gn:BSU07600" /db_xref="EnsemblGenomes-Tr:CAB12589" /db_xref="GOA:O34439" /db_xref="InterPro:IPR005064" /db_xref="SubtiList:BG12950" /db_xref="UniProtKB/Swiss-Prot:O34439" /translation="MKKSIILLNILLIFMQGDIRQAAAPRLPDGPIEIVVPAEPSGGW DVTAQAIQSVLRQKQIVKDDVHIVYKSGGGGEKGWKYVNKSSKQTISMTSSLILSNDL LGQSKLKMSDFTPLAILSKEWQTVALPKGSALTNGKDVLNEINMHPGKVRIGFAPGFG NDDQLSFVRAADMYGIDPFDIQFSQYDSSEQLIQALIRHEIEAASMTLSEAKPYERNG DITLAAVTSDKRLPGFPNVPTWKEQGIPFVFSHWRGILGPKNMSEEEISYWDQALKKV TSSPEWKRKINEQDWESFYLNSRETKRFLEEQSAFYQSIMTGN*" /label="yflP CDS" gene 757453..758412 /gene="yflP" /locus_tag="BSU_07600" /old_locus_tag="BSU07600" /label="yflP gene" downshifts 758381 /Source="Nicolas_upshifts" /id="D379" /incds=0 /nref=76 /ntot=211 /MaxReadThrough="1.1681" /MaxDrop="6.31244" /score="10.4510496" /energy="-6.5" /TU="NA" /idTUdmin="U578" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 758504..758511 /Source="Nicolas_upshift_promotors" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 758524..758543 /Source="Nicolas_upshift_promotors" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 758535..758607 /Source="Nicolas_S_feature" /locus_tag="new_834310_834382" /HighExp="M9-stat, SMMPr, SMM, T0.0H, LoTm, T1.0H, Pyr, T1.30H, Cold, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S262" upshifts 758535 /Source="Nicolas_upshifts" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="upshifts" CDS 758608..759909 /gene="citM" /locus_tag="BSU_07610" /old_locus_tag="BSU07610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12427932, 12533460, 12906362, 12949159, 15849754, 16842348, 16850406, 24415722, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12427932, 12533460, 12906362, 12949159, 15849754, 16842348, 16850406, 24415722, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="transporter of divalent metal ions/citrate complexes" /protein_id="NP_388642.1" /db_xref="EnsemblGenomes-Gn:BSU07610" /db_xref="EnsemblGenomes-Tr:CAB12590" /db_xref="GOA:P55069" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG11832" /db_xref="UniProtKB/Swiss-Prot:P55069" /translation="MLAILGFLMMLVFMALIMTKRLSVLTALVLTPIVFALIAGFGFT EVGDMMISGIQQVAPTAVMIMFAILYFGIMIDTGLFDPMVGKILSMVKGDPLKIVVGT AVLTMLVALDGDGSTTYMITTSAMLPLYLLLGIRPIILAGIAGVGMGIMNTIPWGGAT PRAASALGVDPAELTGPMIPVIASGMLCMVAVAYVLGKAERKRLGVIELKQPANANEP AAAVEDEWKRPKLWWFNLLLTLSLIGCLVSGKVSLTVLFVIAFCIALIVNYPNLEHQR QRIAAHSSNVLAIGSMIFAAGVFTGILTGTKMVDEMAISLVSMIPEQMGGLIPAIVAL TSGIFTFLMPNDAYFYGVLPILSETAVAYGVDKVEIARASIIGQPIHMLSPLVPSTHL LVGLVGVSIDDHQKFALKWAVLAVIVMTAIALLIGAISISV*" /label="citM CDS" gene 758608..759909 /gene="citM" /locus_tag="BSU_07610" /old_locus_tag="BSU07610" /label="citM gene" promotor_-35 759906..759912 /Source="Nicolas_upshift_promotors" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 759926..759937 /Source="Nicolas_upshift_promotors" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 759927 /Source="Nicolas_upshifts" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="upshifts" CDS 759965..760759 /gene="yflN" /locus_tag="BSU_07620" /old_locus_tag="BSU07620" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10972810, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388643.1" /db_xref="EnsemblGenomes-Gn:BSU07620" /db_xref="EnsemblGenomes-Tr:CAB12591" /db_xref="GOA:O34409" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG12949" /db_xref="UniProtKB/Swiss-Prot:O34409" /translation="MSDPYMPLTSVRSGAGFEAAKGVHGLTVQIANVYFIQLPSEPHS FVLIDAGMPQSAGVIVNEAKQRFGEGFQLKAIILTHGHFDHIGAIEEILEHWDVPVYI HSREMPYVTGKEDYPPARPDSKSGLVAKLSPLFPRHSIDISSHVQALPEDGSVPFLDE WMWIATPGHTPGHISLFRDDGRVLVAGDAVITVEQEKMADVLIQKQELHGPPAYFTPD TETAAESILKLAGLEPEALLTGHGIPMTGKNFRSDLTELANRLSSI*" /label="yflN CDS" gene 759965..760759 /gene="yflN" /locus_tag="BSU_07620" /old_locus_tag="BSU07620" /label="yflN gene" downshifts 760735 /Source="Nicolas_upshifts" /id="D380" /incds=0 /nref=2 /ntot=25 /MaxReadThrough="0.0114999999999998" /MaxDrop="3.05232" /score="38.3109333" /energy="-11.8" /TU="NA" /idTUdmin="U580" /TUdmin=132 /isTUend="FALSE" /label="downshifts" promotor_-35 760814..760817 /Source="Nicolas_upshift_promotors" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 760832..760851 /Source="Nicolas_upshift_promotors" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 760845 /Source="Nicolas_upshifts" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="upshifts" CDS 760878..761969 /gene="nosA" /locus_tag="BSU_07630" /old_locus_tag="BSU07630" /EC_number="1.14.13.39" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11856757, 12220171, 16172391, 25643072, 25826316, 26062720" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11856757, 12220171, 16172391, 25643072, 25826316, 26062720; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="nitric-oxide synthase" /protein_id="NP_388644.2" /db_xref="EnsemblGenomes-Gn:BSU07630" /db_xref="EnsemblGenomes-Tr:CAB12592" /db_xref="GOA:O34453" /db_xref="InterPro:IPR004030" /db_xref="InterPro:IPR017142" /db_xref="InterPro:IPR036119" /db_xref="PDB:1M7V" /db_xref="PDB:1M7Z" /db_xref="PDB:2AMO" /db_xref="PDB:2AN0" /db_xref="PDB:2AN2" /db_xref="PDB:2FBZ" /db_xref="PDB:2FC1" /db_xref="PDB:2FC2" /db_xref="PDB:4D3I" /db_xref="PDB:4D3J" /db_xref="PDB:4D3K" /db_xref="PDB:4D3M" /db_xref="PDB:4D3N" /db_xref="PDB:4D3O" /db_xref="PDB:4D3T" /db_xref="PDB:4D3U" /db_xref="PDB:4D3V" /db_xref="PDB:4D7H" /db_xref="PDB:4D7I" /db_xref="PDB:4D7J" /db_xref="PDB:4LWA" /db_xref="PDB:4LWB" /db_xref="PDB:4UG5" /db_xref="PDB:4UG6" /db_xref="PDB:4UG7" /db_xref="PDB:4UG8" /db_xref="PDB:4UG9" /db_xref="PDB:4UGA" /db_xref="PDB:4UGB" /db_xref="PDB:4UGC" /db_xref="PDB:4UGD" /db_xref="PDB:4UGE" /db_xref="PDB:4UGF" /db_xref="PDB:4UGG" /db_xref="PDB:4UGH" /db_xref="PDB:4UGI" /db_xref="PDB:4UGJ" /db_xref="PDB:4UGK" /db_xref="PDB:4UGL" /db_xref="PDB:4UGM" /db_xref="PDB:4UGN" /db_xref="PDB:4UGO" /db_xref="PDB:4UGP" /db_xref="PDB:4UGQ" /db_xref="PDB:4UGR" /db_xref="PDB:4UGS" /db_xref="PDB:4UGT" /db_xref="PDB:4UGU" /db_xref="PDB:4UGV" /db_xref="PDB:4UGW" /db_xref="PDB:4UGX" /db_xref="PDB:4UGY" /db_xref="PDB:4UQR" /db_xref="PDB:4UQS" /db_xref="PDB:5G65" /db_xref="PDB:5G66" /db_xref="PDB:5G67" /db_xref="PDB:5G68" /db_xref="PDB:5G69" /db_xref="PDB:5G6A" /db_xref="PDB:5G6B" /db_xref="PDB:5G6C" /db_xref="PDB:5G6D" /db_xref="PDB:5G6E" /db_xref="PDB:5G6F" /db_xref="PDB:5G6G" /db_xref="PDB:5G6H" /db_xref="PDB:5G6I" /db_xref="PDB:5G6J" /db_xref="PDB:5G6K" /db_xref="PDB:5G6L" /db_xref="PDB:5G6M" /db_xref="PDB:5G6N" /db_xref="PDB:5G6O" /db_xref="PDB:5G6P" /db_xref="PDB:5G6Q" /db_xref="SubtiList:BG12948" /db_xref="UniProtKB/Swiss-Prot:O34453" /translation="MEEKEILWNEAKAFIAACYQELGKEEEVKDRLADIKSEIDLTGS YVHTKEELEHGAKMAWRNSNRCIGRLFWNSLNVIDRRDVRTKEEVRDALFHHIETATN NGKIRPTITIFPPEEKGEKQVEIWNHQLIRYAGYESDGERIGDPASCSLTAACEELGW RGERTDFDLLPLIFRMKGDEQPVWYELPRSLVIEVPITHPDIEAFSDLELKWYGVPII SDMKLEVGGIHYNAAPFNGWYMGTEIGARNLADEKRYDKLKKVASVIGIAADYNTDLW KDQALVELNKAVLHSYKKQGVSIVDHHTAASQFKRFEEQEEEAGRKLTGDWTWLIPPI SPAATHIFHRSYDNSIVKPNYFYQDKPYE*" /label="nosA CDS" gene 760878..761969 /gene="nosA" /locus_tag="BSU_07630" /old_locus_tag="BSU07630" /label="nosA gene" CDS complement(761960..762235) /gene="acyP" /locus_tag="BSU_07640" /old_locus_tag="BSU07640" /EC_number="3.6.1.7" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:20447399" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20447399; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acylphosphatase" /protein_id="NP_388645.1" /db_xref="EnsemblGenomes-Gn:BSU07640" /db_xref="EnsemblGenomes-Tr:CAB12593" /db_xref="GOA:O35031" /db_xref="InterPro:IPR001792" /db_xref="InterPro:IPR017968" /db_xref="InterPro:IPR020456" /db_xref="InterPro:IPR036046" /db_xref="PDB:2FHM" /db_xref="PDB:2HLT" /db_xref="PDB:2HLU" /db_xref="PDB:3BR8" /db_xref="SubtiList:BG12947" /db_xref="UniProtKB/Swiss-Prot:O35031" /translation="MLQYRIIVDGRVQGVGFRYFVQMEADKRKLAGWVKNRDDGRVEI LAEGPENALQSFVEAVKNGSPFSKVTDISVTESRSLEGHHRFSIVYS*" /label="acyP CDS" gene complement(761960..762235) /gene="acyP" /locus_tag="BSU_07640" /old_locus_tag="BSU07640" /label="acyP gene" S_feature 761970..762301 /Source="Nicolas_S_feature" /locus_tag="new_837745_838076" /HighExp="C90, BI, Paraq, LBGexp, Oxctl, M0t45, G150, M40t45, G135, H2O2" /AntisenseName="yflL" /AntisenseCor="0.38657275217332299" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S263" promotor_-10 complement(762249..762268) /Source="Nicolas_upshift_promotors" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(762263) /Source="Nicolas_upshifts" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(762283..762290) /Source="Nicolas_upshift_promotors" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 762302..762967 /gene="yflK" /locus_tag="BSU_07650" /old_locus_tag="BSU07650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11886751; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative sulfur carrier" /protein_id="NP_388646.1" /db_xref="EnsemblGenomes-Gn:BSU07650" /db_xref="EnsemblGenomes-Tr:CAB12594" /db_xref="GOA:O34542" /db_xref="InterPro:IPR005163" /db_xref="InterPro:IPR005302" /db_xref="InterPro:IPR011037" /db_xref="SubtiList:BG12946" /db_xref="UniProtKB/Swiss-Prot:O34542" /translation="MKQERYSVLSLNLGKPQTLEYDGKKIETGIMKRPAKSAVMLYRE NFEGDGQADLVNHGGPDKAVCVYPAEHYPFWEEFLSRPLSNAAFGENLTVAGLTEENV CIGDVFRLDEAVVQVSQPRQPCVKLAKKFGVKEMVLKVQQTGYTGFYFRVLEEGRVSP GANLELLSRGEKGISVQFANRINYHDAKNLTAIERILSEAALSESWRASFMKKKDRLL PVE*" /label="yflK CDS" gene 762302..762967 /gene="yflK" /locus_tag="BSU_07650" /old_locus_tag="BSU07650" /label="yflK gene" CDS complement(763008..763145) /gene="yflJ" /locus_tag="BSU_07660" /old_locus_tag="BSU07660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388647.1" /db_xref="EnsemblGenomes-Gn:BSU07660" /db_xref="EnsemblGenomes-Tr:CAB12595" /db_xref="InterPro:IPR022580" /db_xref="SubtiList:BG12945" /db_xref="UniProtKB/Swiss-Prot:O34345" /translation="MHYGSKGWYVAELKKQGITHHEGRKLQSYKTYFLANLLESKKKQ S*" /label="yflJ CDS" gene complement(763008..763145) /gene="yflJ" /locus_tag="BSU_07660" /old_locus_tag="BSU07660" /label="yflJ gene" downshifts complement(763022) /Source="Nicolas_upshifts" /id="D381" /incds=0 /nref=136 /ntot=260 /MaxReadThrough="0.0927600000000002" /MaxDrop="8.10929" /score="29.8336543" /energy="-14.8" /TU="NA" /idTUdmin="U583" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" S_feature complement(763146..763276) /Source="Nicolas_S_feature" /locus_tag="new_838921_839051_c" /HighExp="S4, S7, S8, S6, S5, S3, B36, BT, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.967, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S264" promotor_-10 complement(763262..763280) /Source="Nicolas_upshift_promotors" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 763272..763277 /Source="Nicolas_upshift_promotors" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(763276) /Source="Nicolas_upshifts" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="upshifts" S_feature 763287..764351 /Source="Nicolas_S_feature" /locus_tag="new_839062_840126" /HighExp="S8, S6, S5, S7, S4, S3, BT, B36, C90, T5.0H" /AntisenseName="mapB" /AntisenseCor="-0.26446079057314398" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S265" upshifts 763288 /Source="Nicolas_upshifts" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 763293..763311 /Source="Nicolas_upshift_promotors" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(763296..763301) /Source="Nicolas_upshift_promotors" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(763302..763457) /gene="yflI" /locus_tag="BSU_07670" /old_locus_tag="BSU07670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388648.1" /db_xref="EnsemblGenomes-Gn:BSU07670" /db_xref="EnsemblGenomes-Tr:CAB12596" /db_xref="GOA:O34905" /db_xref="SubtiList:BG12944" /db_xref="UniProtKB/Swiss-Prot:O34905" /translation="MWFIIFGIIFFIEGIIMTVYGVKKKNGMLTYIGIVFAIMTFGVV MIKLTGH*" /label="yflI CDS" gene complement(763302..763457) /gene="yflI" /locus_tag="BSU_07670" /old_locus_tag="BSU07670" /label="yflI gene" S_feature complement(763458..763563) /Source="Nicolas_S_feature" /locus_tag="new_839233_839338_c" /HighExp="Etha, Salt, Diami, dia15, H2O2, Cold, G135, Paraq, LPhT, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S266" CDS complement(763564..763878) /gene="yflH" /locus_tag="BSU_07680" /old_locus_tag="BSU07680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1070366, 1266368; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388649.1" /db_xref="EnsemblGenomes-Gn:BSU07680" /db_xref="EnsemblGenomes-Tr:CAB12597" /db_xref="InterPro:IPR021637" /db_xref="PDB:3D0W" /db_xref="SubtiList:BG12943" /db_xref="UniProtKB/Swiss-Prot:O34306" /translation="MNRDQEKIQIENEMNAMHGTIKEDILKDFEEFKGYLKKQVNRGK KLGLDDGKLVKSAAILGDYLAKHEEPQNGEEMLLQELWSVADEDEKEHLAQLLVKLVD KQ*" /label="yflH CDS" gene complement(763564..763878) /gene="yflH" /locus_tag="BSU_07680" /old_locus_tag="BSU07680" /label="yflH gene" S_feature complement(763879..763959) /Source="Nicolas_S_feature" /locus_tag="new_839654_839734_c" /HighExp="dia5, dia15, Diami, LBGtran, LPhT, H2O2, Etha, Lbtran, M40t45, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S267" CDS complement(763960..764709) /gene="mapB" /locus_tag="BSU_07690" /old_locus_tag="BSU07690" /EC_number="3.4.11.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16207374" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine aminopeptidase B" /protein_id="NP_388650.1" /db_xref="EnsemblGenomes-Gn:BSU07690" /db_xref="EnsemblGenomes-Tr:CAB12598" /db_xref="GOA:O34484" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR002467" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG12942" /db_xref="UniProtKB/Swiss-Prot:O34484" /translation="MIVTNDQELEGLKKIGRIVALAREEMKRKAEPGMSTKDLDLIGK AVLDEHGAVSAPEKEYDFPGVTCISVNDEVAHGIPSTSKILKAGDLVNIDISAEFGGF YSDTGISFVLGEGEERLHKLCQCAENAFQKGLQQAKAGKRQNQIGRAVYHEARSQGFT VIKTLTGHGIGRSLHEAPNHIMNYYDPFDNALFKNGTVIALEPFISTKAETIVEAGDG WTFKTPDKSMVAQVEHTIVITKDEPIILTKL*" /label="mapB CDS" gene complement(763960..764709) /gene="mapB" /locus_tag="BSU_07690" /old_locus_tag="BSU07690" /label="mapB gene" promotor_-10 complement(764738..764757) /Source="Nicolas_upshift_promotors" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(764751) /Source="Nicolas_upshifts" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(764753..765889) /Source="Nicolas_S_feature" /locus_tag="new_840528_841664_c" /HighExp="S6, S8, S7, S5, BT, C30, Paraq, B36, G180, Pyr" /AntisenseName="nagP" /AntisenseCor="0.180776000778922" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S268" promotor_-35 complement(764769..764777) /Source="Nicolas_upshift_promotors" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 764820..764821 /Source="Nicolas_upshift_promotors" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 764841..764860 /Source="Nicolas_upshift_promotors" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 764844 /Source="Nicolas_upshifts" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="upshifts" CDS 764881..766239 /gene="nagP" /locus_tag="BSU_07700" /old_locus_tag="BSU07700" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 8246840; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) N-acetylglucosamine-specific enzyme IICB component" /protein_id="NP_388651.1" /db_xref="EnsemblGenomes-Gn:BSU07700" /db_xref="EnsemblGenomes-Tr:CAB12599" /db_xref="GOA:O34521" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR010974" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG12941" /db_xref="UniProtKB/Swiss-Prot:O34521" /translation="MLSFLQKLGKSFMLPIAVLPAVGIILALGREDVFNIPFVYQAGT AVFDHLPLIFAIGIAIGISKDSNGAAGLSGAISYLMLDAATKTIDKTNNMAVFGGIIA GLIAGYTYNRFKDTKLPEYLGFFSGRRLVPILTAIITIILAGIFGVVWPPIQSCINSF GEWMLGLGGIGAGIFGLFNRLLIPLGLHHVLNNIFWFQFGEYNGVTGDLARFFAKDPT AGTYMTGFFPIMMFGLPAACLAMVVTAKPSKRKATAGMMIGFALTAFITGITEPIEFA FMFLSPLLYAVHAVLTGLSLFIVNWLGIRSGFSFSAGAIDYVLSYGIAEKPLLLLLVG ICYAAVYFIVFYVLIKALNLKTPGREDDDVDEVLDENTVQDVNENIMLKGLGGKENLQ TIDHCATRLRLTVKDTALVDEALLKKAGAKGVVKSGGQSVQVIIGPNVEFAAEELRAA VK*" /label="nagP CDS" gene 764881..766239 /gene="nagP" /locus_tag="BSU_07700" /old_locus_tag="BSU07700" /label="nagP gene" promotor_-10 complement(765875..765894) /Source="Nicolas_upshift_promotors" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(765889) /Source="Nicolas_upshifts" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(765908..765917) /Source="Nicolas_upshift_promotors" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 766125 /Source="Nicolas_upshifts" /id="D382" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="3.67421" /MaxDrop="3.12268" /score="44.7832762" /energy="-16.9" /TU="U586" /idTUdmin="U586" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts 766235 /Source="Nicolas_upshifts" /id="D383" /incds=0 /nref=2 /ntot=87 /MaxReadThrough="2.54331" /MaxDrop="3.17508" /score="44.7832762" /energy="-16.9" /TU="NA" /idTUdmin="U586" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(766272..768221) /gene="ltaSB" /locus_tag="BSU_07710" /old_locus_tag="BSU07710" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10658653, 21255105" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658653, 21255105; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme responsible for polyglycerolphosphate LTAsynthesis" /protein_id="NP_388652.1" /db_xref="EnsemblGenomes-Gn:BSU07710" /db_xref="EnsemblGenomes-Tr:CAB12600" /db_xref="GOA:O34952" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="PDB:2W8D" /db_xref="SubtiList:BG12940" /db_xref="UniProtKB/Swiss-Prot:O34952" /translation="MKTFIKERGLAFFLIAVVLLWIKTYVGYVLNFNLGIDNTIQKIL LFVNPLSSSLFFLGFGLLFKKKLQQTAIIVIHFLMSFLLYANIVYYRFFNDFITIPVI MQAKTNGGQLGDSAFSLMRPTDAFYFIDTIILIILAIKVNKPAETSSKKSFRIIFASS ILVFLINLAVAESDRPELLTRSFDRNYLVKYLGTYNFTIYDAVQNIKSNSQRALADSS DVTEVENYMKANYDVPNNVYFGKAEGKNVIYVSLESLQSFIIDYKIDGKEVTPFLNKL AHDNETFYFDNFFHQTGQGKTSDAEFMMENSLYPLAQGSVFVNKAQNTLQSVPAILKS KNYTSATFHGNTQTFWNRNEMYKAEGIDKFFDSAYYDMNEENTKNYGMKDKPFFKESM PLLESLPQPFYTKFITLSNHFPFGMDEGDTDFPAGDFGDSVVDNYFQSAHYLDQSIEQ FFNDLKKDGLYDKSIIVMYGDHYGISENHNKAMAKVLGKDEITDYDNAQLQRVPLFIH AAGVKGEKVHKYAGDVDVAPTILHLLGVDTKDYLMSGSDILSKEHREVIPFRNGDFIS PKYTKISGKYYDTKTGKELDESEVDKSEDSLVKKELEMSDKIINGDLLRFYEPKGFKK VNPSDYDYTKHDEDSSETSKDNEDK*" /label="ltaSB CDS" gene complement(766272..768221) /gene="ltaSB" /locus_tag="BSU_07710" /old_locus_tag="BSU07710" /label="ltaSB gene" downshifts complement(766289) /Source="Nicolas_upshifts" /id="D384" /incds=0 /nref=219 /ntot=250 /MaxReadThrough="1.71031" /MaxDrop="6.08461" /score="43.6427282" /energy="-15.9" /TU="NA" /idTUdmin="U589" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 767331..767337 /Source="Nicolas_upshift_promotors" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 767353..767371 /Source="Nicolas_upshift_promotors" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 767357..768321 /Source="Nicolas_S_feature" /locus_tag="new_843132_844096" /HighExp="Etha, Salt, Sw, Gly, C30, M9-stat, S8, B60, BC, S7" /AntisenseName="yflE" /AntisenseCor="-0.385555454026206" /AntisenseRegPval="-10.199999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S269" upshifts 767357 /Source="Nicolas_upshifts" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(768222..768296) /Source="Nicolas_S_feature" /locus_tag="new_843997_844071_c" /HighExp="Paraq, H2O2, LBGexp, G150, G135, G180, Lbexp, C30, LPhT, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S270" promotor_-10 complement(768273..768292) /Source="Nicolas_upshift_promotors" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(768296) /Source="Nicolas_upshifts" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(768298..768820) /Source="Nicolas_S_feature" /locus_tag="new_844073_844595_c" /HighExp="S3, LoTm, S7, S4, S5, S8, S6, M9-stat, C30, Pyr" /AntisenseName="yflD" /AntisenseCor="0.24383322556613099" /AntisenseRegPval="-4.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S271" promotor_-35 complement(768308..768312) /Source="Nicolas_upshift_promotors" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 768322..768459 /gene="yflD" /locus_tag="BSU_07720" /old_locus_tag="BSU07720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388653.1" /db_xref="EnsemblGenomes-Gn:BSU07720" /db_xref="EnsemblGenomes-Tr:CAB12601" /db_xref="SubtiList:BG12939" /db_xref="UniProtKB/Swiss-Prot:O34489" /translation="MREKVAKNAVESTFRFDITKCKTRYLSRNKGIKWYIENCMIKYK V*" /label="yflD CDS" gene 768322..768459 /gene="yflD" /locus_tag="BSU_07720" /old_locus_tag="BSU07720" /label="yflD gene" upshifts 768437 /Source="Nicolas_upshifts" /id="U590" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.895104895104895" /psig="0.952047952047952" /xcortree=589 /SigmaFactorBS="ccaaatgtaaaacaaggtatctttctagaaataaaggaataa aatggtacattgagaattgTATGATAAAATATAAGGTATagataaaaagaggtgaaat g" /listShort="yflB" /listLong="yflA, S272" /label="upshifts" misc_feature 768438..768457 /Source="Nicolas_upshift_promotors" /id="U590" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.895104895104895" /psig="0.952047952047952" /xcortree=589 /SigmaFactorBS="ccaaatgtaaaacaaggtatctttctagaaataaaggaataa aatggtacattgagaattgTATGATAAAATATAAGGTATagataaaaagaggtgaaat g" /listShort="yflB" /listLong="yflA, S272" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 768478..768870 /gene="yflB" /locus_tag="BSU_07735" /old_locus_tag="BSU07735" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388655.2" /db_xref="EnsemblGenomes-Gn:BSU07735" /db_xref="EnsemblGenomes-Tr:CAB12603" /db_xref="InterPro:IPR018961" /db_xref="SubtiList:BG12937" /db_xref="UniProtKB/Swiss-Prot:O34887" /translation="MDFSHIVSEDKIKRAIKDGDFQNLPGMGKPLPKDDAAHLPESLR MGYRILKNAGMAEDEGALKKELMTIDHLIEKCYDEKEREQLIRKKSEKQLLLDKLVDK KGMFSKPASAFYKNKVYDRLGRNRPSSS*" /label="yflB CDS" gene 768478..768870 /gene="yflB" /locus_tag="BSU_07735" /old_locus_tag="BSU07735" /label="yflB gene" promotor_-10 complement(768818..768836) /Source="Nicolas_upshift_promotors" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(768833) /Source="Nicolas_upshifts" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(768852..768857) /Source="Nicolas_upshift_promotors" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 768939..768945 /Source="Nicolas_upshift_promotors" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 768960..768978 /Source="Nicolas_upshift_promotors" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 768960 /Source="Nicolas_upshifts" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="upshifts" CDS 768995..770410 /gene="yflA" /locus_tag="BSU_07750" /old_locus_tag="BSU07750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid transporter" /protein_id="NP_388656.1" /db_xref="EnsemblGenomes-Gn:BSU07750" /db_xref="EnsemblGenomes-Tr:CAB12604" /db_xref="GOA:O34708" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG12936" /db_xref="UniProtKB/Swiss-Prot:O34708" /translation="MERLLVWIEHISDWLWGPPLIILLTGTGLYFTILLKGFQFRYPL YIFKQTIGSVGKKPKGEGTVTPLQALTSALSSTIGAANIVGVPAAIMFGGPGAVFWMW LIALFAMAIKFSESVLAVHYREKNEQGEYVGGPMYYITKGLRMKWLGVFFSVALIVEL IPSIMVQGNSVSVSLAETFSFNKIYAGIGIAFLIGLVVIGGVKRIGKVTEFVVPLMAG AYAGAGLLIVLMNLSSVPAFFSLVFSNAFTSSSAVGGFAGAALAETVRWGFARGLYSN EAGMGTAPIAHAAAMTDHPVRQGFWSVIGIVIDTLIICTTTAFIVLASGVWTGKNASN DPAALTTAAFQHYFGSGGGYFVSVSLVFFVVSTIMVVIFYGVKQAEFLFGRLAGHVIK FVYLAAIIIGAAGGAKAIWGVLDLALVFIVVPNVIALLLLSRKVKALYTEFFTSEQYY LKDIRKTKQKPVYPTKEAKNS*" /label="yflA CDS" gene 768995..770410 /gene="yflA" /locus_tag="BSU_07750" /old_locus_tag="BSU07750" /label="yflA gene" downshifts complement(768996) /Source="Nicolas_upshifts" /id="D385" /incds=0 /nref=4 /ntot=16 /MaxReadThrough="0.76492" /MaxDrop="4.20973" /score="43.6427282" /energy="-15.9" /TU="NA" /idTUdmin="U593" /TUdmin=22 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(769022..769122) /Source="Nicolas_upshift_promotors" /id="U593" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.723276723276723" /psig="0.006993006993007" /xcortree=122 /SigmaFactorBS="ggatagcgaaattgaaaacctttcagcaaaatagtgaaatac aagcccgtccccgtcagcaggatgattagcggcggaccccacagccaatcagatatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(769062) /Source="Nicolas_upshifts" /id="U593" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.723276723276723" /psig="0.006993006993007" /xcortree=122 /SigmaFactorBS="ggatagcgaaattgaaaacctttcagcaaaatagtgaaatac aagcccgtccccgtcagcaggatgattagcggcggaccccacagccaatcagatatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(770407..771483) /gene="yfkT" /locus_tag="BSU_07760" /old_locus_tag="BSU07760" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 15849754, 16850406, 23625846; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative spore germination integral inner membrane transporter" /protein_id="NP_388657.1" /db_xref="EnsemblGenomes-Gn:BSU07760" /db_xref="EnsemblGenomes-Tr:CAB12605" /db_xref="GOA:O34573" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG12935" /db_xref="UniProtKB/Swiss-Prot:O34573" /translation="MDKTSAYQGLFFGALYTLAVGLKHAPILMIESAKQNAWHSYILG VVIVIPALWLMHRLMKKHQDKNIYELLSDSSPIAGRIIILLFSLYFLLINAHDIRFFI NLINILFLPRTPMAVLGGVIIFVAICIAREGKETLTRMAQIFLFPFGILVLFLPFTLA TQIELQNLTPVFEGLIPYLQSGYYAFGTMGELIILPLLFSNRSVPLKYTIFAILLGAL LLAVMLFSSISVFGPNLTSTFFDPAYMVIRQIRITDFLDRSDLIIAAFWIPVIMVKIA GSLYIVVYGLSFLHSKIDPKAMYTPTGMFSVVCGFWFFLNTNQLIDFNRIKPIINVVI SLLLPLLIYLIIKSKALFGAKAKH*" /label="yfkT CDS" gene complement(770407..771483) /gene="yfkT" /locus_tag="BSU_07760" /old_locus_tag="BSU07760" /label="yfkT gene" S_feature 770411..773777 /Source="Nicolas_S_feature" /locus_tag="new_846186_849552" /HighExp="Salt, Sw, Etha, LoTm, B36, Heat, LPhT, BC, T0.30H, H2O2" /AntisenseName="yfkR" /AntisenseCor="-1.3937740774571999E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.952" /label="S272" CDS complement(771507..771707) /gene="yfkS" /locus_tag="BSU_07770" /old_locus_tag="BSU07770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23625846; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative spore germination D protein" /protein_id="NP_388658.1" /db_xref="EnsemblGenomes-Gn:BSU07770" /db_xref="EnsemblGenomes-Tr:CAB12606" /db_xref="GOA:O35036" /db_xref="SubtiList:BG12934" /db_xref="UniProtKB/Swiss-Prot:O35036" /translation="MISYIVQTLIVCIAIYAYEWKNFRSANNLTKWAFSLLIAGSAFL WIYMRVNPLLPRLGHLFKYIPF*" /label="yfkS CDS" gene complement(771507..771707) /gene="yfkS" /locus_tag="BSU_07770" /old_locus_tag="BSU07770" /label="yfkS gene" CDS complement(771723..772877) /gene="yfkR" /locus_tag="BSU_07780" /old_locus_tag="BSU07780" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 23625846; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_388659.1" /db_xref="EnsemblGenomes-Gn:BSU07780" /db_xref="EnsemblGenomes-Tr:CAB12607" /db_xref="GOA:O35028" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG12933" /db_xref="UniProtKB/Swiss-Prot:O35028" /translation="MKKTIYKCVLPLLICILLTGCWDRTEINDIAFVVSSAIDKKKDQ YRVAMQIPLVGQLGGQTGGGGGTAGSKTWYVDSASGTTIREANNKLQTSLSRTINTSH RRTVIIGEDMARDGVAPVFDILTRNPQNRLTALILVSRGEARDILNTDVQLEQFPAEM IRELAIIATSRPVFLSRFMSDLVEIGSDPYAPVISASKTKPGGKGKSNLKIDGLAIFK KDRLMDIFKDEHMTAALMLLNQARQPEFIVDLPNQMGQASIQLQKSNASFHAAEKNGK LSMTIEIRAKGIIMENQSTYETRENDQYYIIQKALNRTIKKDVISTVHRLQKLKADPA GFQDRTIRSTATTKNLLKKEWEEVYKDMEVHVVPIVTIEQGGVLYKTISH*" /label="yfkR CDS" gene complement(771723..772877) /gene="yfkR" /locus_tag="BSU_07780" /old_locus_tag="BSU07780" /label="yfkR gene" CDS complement(772858..774399) /gene="yfkQ" /locus_tag="BSU_07790" /old_locus_tag="BSU07790" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 23625846; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_388660.1" /db_xref="EnsemblGenomes-Gn:BSU07790" /db_xref="EnsemblGenomes-Tr:CAB12608" /db_xref="GOA:O34486" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG12932" /db_xref="UniProtKB/Swiss-Prot:O34486" /translation="MNKRDKALQLIKELEDNQDRPISPNLKENLENLTLLTEGCSDIV FRQFDFGNGLCGFIVYIEGIVKSEHIQDHALRPFLMHLTDQIDEHEEALQNTLSISSV ALETSMSKVAASIIEGNAVLFADGHSKGLILNIKGGQRRSIEEPITESTIRGSREGFT ESLRVNTALVRFRVKTFQLKMISFKIGTKTKTDVVLAYIDGLADPKVIDKAKKRIKKI KIDAVLESGYIEEFIEDDTYSPFPQLQYTERPDTVAAQLLEGRFAIFTDNTPFVLTGP ITFWQLMQASEDYYERYLMSNLIRWLRYMFLFVALYLPAIYVAVITYHQDLMPTNLMF SVASAREPIPFPAIIEALIMEISFEALREAGVRLPKTIGQTVSILGALVIGTAAVEAG IVSAPMVIIVSLTGIASFTIPRFNLAISIRMLRFPLMFLASIFGIFGIMLGTIILVLH LCKLQSFGIPYLSGISPFKRDEVKDIFVRAPWWTMTRRPGTYSRGNGQKGAKREDPKD EENNI*" /label="yfkQ CDS" gene complement(772858..774399) /gene="yfkQ" /locus_tag="BSU_07790" /old_locus_tag="BSU07790" /label="yfkQ gene" promotor_-10 complement(774449..774460) /Source="Nicolas_upshift_promotors" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(774452) /Source="Nicolas_upshifts" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(774474..774480) /Source="Nicolas_upshift_promotors" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 774509..774516 /Source="Nicolas_upshift_promotors" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 774531..774550 /Source="Nicolas_upshift_promotors" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 774538 /Source="Nicolas_upshifts" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(774584) /Source="Nicolas_upshifts" /id="D386" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="1.35091" /MaxDrop="3.57201" /score="22.8661179" /energy="-15.2" /TU="NA" /idTUdmin="U596" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 774592..776004 /gene="treP" /locus_tag="BSU_07800" /old_locus_tag="BSU07800" /EC_number="2.7.1.201" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 8755887, 8917076, 8969503, 18977770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 8755887, 8917076, 8969503, 18977770; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) trehalose-specific enzyme IIBC component" /protein_id="NP_388661.1" /db_xref="EnsemblGenomes-Gn:BSU07800" /db_xref="EnsemblGenomes-Tr:CAB12609" /db_xref="GOA:P39794" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR011296" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11009" /db_xref="UniProtKB/Swiss-Prot:P39794" /translation="MGELNKSARQIVEAVGGAENIAAATHCVTRLRFALIDESKVDQE MLDQIDVVKGSFSTNGQFQVVIGQGTVNKVYAELVKETGIGESTKDEVKKASEKNMNP LQRAVKTLADIFIPILPAIVTAGLLMGINNILTAEGIFFSTKSIVQVYPQWADLANMI NLIAGTAFTFLPALIGWSAVKRFGGNPLLGIVLGVMLVHPDLLNAWGYGAAEQSGEIP VWNLFGLEVQKVGYQGQVLPILLASYMLAKIEVFLTKRTPEGIQLLVVAPITLLLTGF ASFIIIGPITFAIGNVLTSGLISVFGSFAALGGLLYGGFYSALVITGMHHTFLAVDLQ LIGSKLGGTFLWPMLALSNIAQGSAALAMMFIVKDEKQKGLSLTSGISAYLGITEPAI FGVNLRYRFPFIIAMVSSGLAGMYISSQGVLASSVGVGGVPGIFSIMSQYWGAFAIGM AIVLIVPFAGTYAYARFKHK*" /label="treP CDS" gene 774592..776004 /gene="treP" /locus_tag="BSU_07800" /old_locus_tag="BSU07800" /label="treP gene" promotor_no_box complement(774610..774710) /Source="Nicolas_upshift_promotors" /id="U596" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.66033966033966" /psig="0.0889110889110889" /xcortree=1570 /SigmaFactorBS="ttgctttcatctattaaagcaaaacgcaaacgtgtaacacaa tgagttgccgctgcaatattttcagcaccgccgactgcttcgacaatctgacgtgccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(774650) /Source="Nicolas_upshifts" /id="U596" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.66033966033966" /psig="0.0889110889110889" /xcortree=1570 /SigmaFactorBS="ttgctttcatctattaaagcaaaacgcaaacgtgtaacacaa tgagttgccgctgcaatattttcagcaccgccgactgcttcgacaatctgacgtgccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 776075..777760 /gene="treA" /locus_tag="BSU_07810" /old_locus_tag="BSU07810" /EC_number="3.2.1.93" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7651129, 7751281, 8755887, 8917076, 9701821, 26894535" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7651129, 7751281, 8755887, 8917076, 9701821, 26894535; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="trehalose-6-phosphate hydrolase" /protein_id="NP_388662.1" /db_xref="EnsemblGenomes-Gn:BSU07810" /db_xref="EnsemblGenomes-Tr:CAB12610" /db_xref="GOA:P39795" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR012769" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="SubtiList:BG11010" /db_xref="UniProtKB/Swiss-Prot:P39795" /translation="MKTEQTPWWKKAVVYQIYPKSFNDTTGNGVGDLNGIIEKLDYLK TLQVDVLWLTPIYDSPQHDNGYDIRDYYSIYPEYGTMEDFERLVSEAHKRDLKVVMDL VVNHTSTEHKWFREAISSIDSPYRDFYIWKKPQENGSVPTNWESKFGGSAWELDEASG QYYLHLFDVTQADLNWENEEVRKHVYDMMHFWFEKGIDGFRLDVINLISKDQRFPNAE EGDGRSFYTDGPRVHEFLHEMNEKVFSHYDSMTVGEMSSTTVDHCIRYTNPDNKELDM TFSFHHLKVDYPNGEKWALAPFDFLKLKEILSDWQTGMHAGGGWNALFWCNHDQPRVV SRYGDDGAYRVKSAKMLATAIHMMQGTPYIYQGEELGMTNPKFTDISSYRDVESLNMY HAFKEKGMADQDITAILQAKSRDNSRTPVQWDATENGGFTTGTPWIPVAGNYREINAE AALRDQNSVFYHYQKLIQIRKMYDIVTEGTYEIIAKDDPNIFAYLRHGSNEKLLVINN FYGTEAAFTLPDSLAPDEWKAEVLLTNDEAREGLQNMTLRPYESIVYRLTKPC*" /label="treA CDS" gene 776075..777760 /gene="treA" /locus_tag="BSU_07810" /old_locus_tag="BSU07810" /label="treA gene" promotor_-10 complement(776381..776396) /Source="Nicolas_upshift_promotors" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(776388) /Source="Nicolas_upshifts" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(776409..776418) /Source="Nicolas_upshift_promotors" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 777733..777737 /Source="Nicolas_upshift_promotors" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 777753..777772 /Source="Nicolas_upshift_promotors" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 777756 /Source="Nicolas_upshifts" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="upshifts" CDS 777781..778497 /gene="treR" /locus_tag="BSU_07820" /old_locus_tag="BSU07820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8755887, 9829827, 17705272" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755887, 9829827, 17705272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (TreR-trehalose)" /protein_id="NP_388663.1" /db_xref="EnsemblGenomes-Gn:BSU07820" /db_xref="EnsemblGenomes-Tr:CAB12611" /db_xref="GOA:P39796" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR012770" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2OGG" /db_xref="SubtiList:BG11011" /db_xref="UniProtKB/Swiss-Prot:P39796" /translation="MKVNKFITIYKDIAQQIEGGRWKAEEILPSEHELTAQYGTSRET VRKALHMLAQNGYIQKIRGKGSVVLNREKMQFPVSGLVSFKELAQTLGKETKTTVHKF GLEPPSELIQKQLRANLDDDIWEVIRSRKIDGEHVILDKDYFFRKHVPHLTKEICENS IYEYIEGELGLSISYAQKEIVAEPCTDEDRELLDLRGYDHMVVVRNYVFLEDTSLFQY TESRHRLDKFRFVDFARRGK*" /label="treR CDS" gene 777781..778497 /gene="treR" /locus_tag="BSU_07820" /old_locus_tag="BSU07820" /label="treR gene" downshifts 778490 /Source="Nicolas_upshifts" /id="D387" /incds=0 /nref=3 /ntot=115 /MaxReadThrough="6.58905" /MaxDrop="4.05981" /score="24.6748216" /energy="-11.1" /TU="U595,U598" /idTUdmin="U595" /TUdmin="-792" /isTUend="FALSE" /label="downshifts" promotor_-35 778572..778575 /Source="Nicolas_upshift_promotors" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 778591..778610 /Source="Nicolas_upshift_promotors" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 778600 /Source="Nicolas_upshifts" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="upshifts" CDS 778637..779302 /gene="hypO" /locus_tag="BSU_07830" /old_locus_tag="BSU07830" /EC_number="1.5.1.39" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15252706, 20727918, 20862523, 22238377, 26415543" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15252706, 20727918, 20862523, 22238377, 26415543; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD(P)H-flavin oxidoreductase (nitroreductase)" /protein_id="NP_388664.1" /db_xref="EnsemblGenomes-Gn:BSU07830" /db_xref="EnsemblGenomes-Tr:CAB12612" /db_xref="GOA:O34475" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="InterPro:IPR033878" /db_xref="SubtiList:BG12931" /db_xref="UniProtKB/Swiss-Prot:O34475" /translation="MADLKTQILDAYNFRHATKEFDPNKKVSDSDFEFILETGRLSPS SLGLEPWKFVVVQNPEFREKLREYTWGAQKQLPTASHFVLILARTAKDIKYNADYIKR HLKEVKQMPQDVYEGYLSKTEEFQKNDLHLLESDRTLFDWASKQTYIALGNMMTAAAQ IGVDSCPIEGFQYDHIHRILEEEGLLENGSFDISVMVAFGYRVRDPRPKTRSAVEDVV KWV*" /label="hypO CDS" gene 778637..779302 /gene="hypO" /locus_tag="BSU_07830" /old_locus_tag="BSU07830" /label="hypO gene" downshifts 779283 /Source="Nicolas_upshifts" /id="D388" /incds=0 /nref=180 /ntot=269 /MaxReadThrough="0.70079" /MaxDrop="6.77615" /score="34.5750428" /energy="-16.9" /TU="NA" /idTUdmin="U595" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(779339..783727) /gene="yfkN" /locus_tag="BSU_07840" /old_locus_tag="BSU07840" /EC_number="3.1.4.16" /EC_number="3.1.3.5" /EC_number="3.1.3.6" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14688230, 16291680, 21800427, 21906378, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported 2',3'-cyclic-nucleotide 2'-phosphodiesterase, 2' (or 3') nucleotidase and 5' nucleotidase" /protein_id="NP_388665.1" /db_xref="EnsemblGenomes-Gn:BSU07840" /db_xref="EnsemblGenomes-Tr:CAB12613" /db_xref="GOA:O34313" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006146" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036907" /db_xref="PDB:3GVE" /db_xref="SubtiList:BG12930" /db_xref="UniProtKB/Swiss-Prot:O34313" /translation="MRIQKRRTHVENILRILLPPIMILSLILPTPPIHAEESAAPQVH LSILATTDIHANMMDYDYYSDKETADFGLARTAQLIQKHREQNPNTLLVDNGDLIQGN PLGEYAVKYQKDDIISGTKTHPIISVMNALKYDAGTLGNHEFNYGLDFLDGTIKGADF PIVNANVKTTSGENRYTPYVINEKTLIDENGNEQKVKVGYIGFVPPQIMTWDKKNLEG QVQVQDIVESANETIPKMKAEGADVIIALAHTGIEKQAQSSGAENAVFDLATKTKGID AIISGHQHGLFPSAEYAGVAQFNVEKGTINGIPVVMPSSWGKYLGVIDLKLEKADGSW KVADSKGSIESIAGNVTSRNETVTNTIQQTHQNTLEYVRKPVGKTEADINSFFAQVKD DPSIQIVTDAQKWYAEKEMKDTEYKNLPILSAGAPFKAGGRNGANYYTNIPAGDLAIK NVGDLYLYDNTVQIVKLTGSEVKDWLEMSAGQFNQIDPAKGGDQALLNENFRSYNFDV IDGVTYQVDVTKPAKYNENGKVINADSSRIINLSYEGKPISPSQEFLVVTNNYRASGG GGFPHLTSDKIVHGSAVENRQVLMDYIIEQKTVNPKADNNWSIAPVSGTNLTFESSLL AKPFADKADDVAYVGKSANEGYGVYKLQFDDDSNPDPPKDGLWDLTVMHTNDTHAHLD DAARRMTKINEVRSETNHNILLDAGDVFSGDLYFTKWNGLADLKMMNMMGYDAMTFGN HEFDKGPTVLSDFLSGNSATVDPANRYHFEAPEFPIVSANVDVSNEPKLKSFVKKPQT FTAGEKKEAGIHPYILLDVDGEKVAVFGLTTEDTATTSSPGKSIVFNDAFETAQNTVK AIQEEEKVNKIIALTHIGHNRDLELAKKVKGIDLIIGGHTHTLVDKMEVVNNEEPTIV AQAKEYGQFLGRVDVAFDEKGVVQTDKSNLSVLPIDEHTEENPEAKQELDQFKNELED VKNEKVGYTDVALDGQREHVRTKETNLGNFIADGMLAKAKEAAGARIAITNGGGIRAG IDKGDITLGEVLNVMPFGNTLYVADLTGKQIKEALEQGLSNVENGGGAFPQVAGIEYT FTLNNKPGHRVLEVKIESPNGDKVAINTDDTYRVATNNFVGAGGDGYSVFTEASHGED LGYVDYEIFTEQLKKLGNKVSPKVEGRIKEVFLPTKQKDGSWTLDEDKFAIYAKNANT PFVYYGIHEGSQEKPINLKVKKDQVKLLKERESDPSLTMFNYWYSMKMPMANLKTADT AIGIKSTGELDVSLSDVYDFTVKQKGKEIKSFKEPVQLSLRMFDIEEAHNPAIYHVDR KKKAFTKTGHGSVDDDMVTGYTNHFSEYTILNSGSNNKPPAFPSDQPTGGDDGNHGGG SDKPGGKQPTDGNGGNDTPPGTQPTNGSGGNGSGGSGTDGPAGGLLPDTATSMYSILL AGFLISALGTAMYLHQRRKQNRANQA*" /label="yfkN CDS" gene complement(779339..783727) /gene="yfkN" /locus_tag="BSU_07840" /old_locus_tag="BSU07840" /label="yfkN gene" downshifts complement(779358) /Source="Nicolas_upshifts" /id="D389" /incds=0 /nref=155 /ntot=229 /MaxReadThrough="1.00159" /MaxDrop="7.08591" /score="22.8661179" /energy="-15.2" /TU="NA" /idTUdmin="U600" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(783760..783779) /Source="Nicolas_upshift_promotors" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(783777) /Source="Nicolas_upshifts" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(783794..783797) /Source="Nicolas_upshift_promotors" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 783904..783910 /Source="Nicolas_upshift_promotors" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 783924..783942 /Source="Nicolas_upshift_promotors" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 783927 /Source="Nicolas_upshifts" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="upshifts" CDS 783970..784488 /gene="sufLB" /locus_tag="BSU_07850" /old_locus_tag="BSU07850" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10220166, 12354229, 16181642, 17257049, 17933887, 24330391, 25283443, 25561404" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 12354229, 16181642, 17257049, 17933887, 24330391, 25283443, 25561404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="general stress protein 18; deglycase" /protein_id="NP_388666.1" /db_xref="EnsemblGenomes-Gn:BSU07850" /db_xref="EnsemblGenomes-Tr:CAB12614" /db_xref="GOA:P80876" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR006286" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12929" /db_xref="UniProtKB/Swiss-Prot:P80876" /translation="MGKKIAVVLTYYFEDSEYTEPAKAFKEAGHELTVIEKEKGKTVK GKQGTAEVTVDASIDDVNSSDFDALLIPGGFSPDQLRADDRFVQFTKAFMTDKKPVFA ICHGPQLLINAKALDGRKATGYTSIRVDMENAGADVVDKEVVVCQDQLVTSRTPDDIP AFNRESLALLEK*" /label="sufLB CDS" gene 783970..784488 /gene="sufLB" /locus_tag="BSU_07850" /old_locus_tag="BSU07850" /label="sufLB gene" downshifts 784474 /Source="Nicolas_upshifts" /id="D390" /incds=0 /nref=35 /ntot=153 /MaxReadThrough="8.02255" /MaxDrop="6.97573" /score="42.2080398" /energy="-12.9" /TU="U601" /idTUdmin="U601" /TUdmin="-3542" /isTUend="FALSE" /label="downshifts" downshifts complement(784518) /Source="Nicolas_upshifts" /id="D391" /incds=0 /nref=22 /ntot=199 /MaxReadThrough="1.59285" /MaxDrop="3.61098" /score="31.1923457" /energy="-11.1" /TU="NA" /idTUdmin="U602" /TUdmin=10 /isTUend="TRUE" /label="downshifts" S_feature 784519..786169 /Source="Nicolas_S_feature" /locus_tag="new_860294_861944" /HighExp="Etha, S6, S8, S5, S7, Gly, Salt, LoTm, S4, Diami" /AntisenseName="yfkL" /AntisenseCor="-0.52109661167911703" /AntisenseRegPval="-19.399999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S273" CDS complement(784528..785718) /gene="yfkL" /locus_tag="BSU_07860" /old_locus_tag="BSU07860" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16828913, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="efflux transporter" /protein_id="NP_388667.1" /db_xref="EnsemblGenomes-Gn:BSU07860" /db_xref="EnsemblGenomes-Tr:CAB12615" /db_xref="GOA:O34597" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12928" /db_xref="UniProtKB/Swiss-Prot:O34597" /translation="MQTTSIKTASGMYINYFFLGMVNIILASNMSSLTKQWNTDPTGI SYVIAAIGFGKLLTYGISGVLSDKIGRKPLVVASAGIMAVFLVGIPLSPSYELAFVFA LLAGVANSAMDAGTYPALTELFPSASGSANVLVKAFMSVGAALLPLLITFLADHSMFY GFAFYLPAAVYLLNIIYLSTLSFPKKHKKPTNSGQQESPVFLSEPVFQKEGTALIIIG FTSTALFTVSQIWLPSYAQKAAGLAESASVQLLSYYSIGSLASVLLLAVLLNRWVKPV FITLLYPIITLCTLAVMLTVHIPVVLDITAFFLGFSTAGVFQITITLMTELFWKRKGT VTGIVATASSLASILLPIATGLIAKAGGIAHIFIFDFGIAVIGTAAAAFLYYRYKKLT GAQA*" /label="yfkL CDS" gene complement(784528..785718) /gene="yfkL" /locus_tag="BSU_07860" /old_locus_tag="BSU07860" /label="yfkL gene" S_feature complement(785719..785810) /Source="Nicolas_S_feature" /locus_tag="new_861494_861585_c" /HighExp="C90, MG 10, BMM, MG-0.2, MG t5, MG 5, MG-0.1, UNK1, HPh, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S274" CDS complement(785811..786026) /gene="yfkK" /locus_tag="BSU_07870" /old_locus_tag="BSU07870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388668.1" /db_xref="EnsemblGenomes-Gn:BSU07870" /db_xref="EnsemblGenomes-Tr:CAB12616" /db_xref="InterPro:IPR009507" /db_xref="SubtiList:BG12927" /db_xref="UniProtKB/Swiss-Prot:O35019" /translation="MSSPNTETLTQMIEEISQKLNMLNVGVIKAEDFSDEKIEDLTYL HRMVMKKESFSPSEMQAIAQELASLRK*" /label="yfkK CDS" gene complement(785811..786026) /gene="yfkK" /locus_tag="BSU_07870" /old_locus_tag="BSU07870" /label="yfkK gene" downshifts complement(785870) /Source="Nicolas_upshifts" /id="D392" /incds=0 /nref=1 /ntot=131 /MaxReadThrough="3.65318" /MaxDrop="2.45155" /score="16.183887" /energy="-11.6" /TU="U602" /idTUdmin="U602" /TUdmin="-1342" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(786058..786077) /Source="Nicolas_upshift_promotors" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(786072) /Source="Nicolas_upshifts" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(786092..786093) /Source="Nicolas_upshift_promotors" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 786139..786146 /Source="Nicolas_upshift_promotors" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 786161..786180 /Source="Nicolas_upshift_promotors" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 786171 /Source="Nicolas_upshifts" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="upshifts" CDS 786229..786699 /gene="yfkJ" /locus_tag="BSU_07880" /old_locus_tag="BSU07880" /EC_number="3.1.3.48" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15995210" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995210; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein-tyrosine-phosphatase" /protein_id="NP_388669.1" /db_xref="EnsemblGenomes-Gn:BSU07880" /db_xref="EnsemblGenomes-Tr:CAB12617" /db_xref="GOA:O35016" /db_xref="InterPro:IPR017867" /db_xref="InterPro:IPR023485" /db_xref="InterPro:IPR036196" /db_xref="PDB:4ETM" /db_xref="SubtiList:BG12926" /db_xref="UniProtKB/Swiss-Prot:O35016" /translation="MISVLFVCLGNICRSPMAEAIFRDLAAKKGLEGKIKADSAGIGG WHIGNPPHEGTQEILRREGISFDGMLARQVSEQDLDDFDYIIAMDAENIGSLRSMAGF KNTSHIKRLLDYVEDSDLADVPDPYYTGNFEEVCQLIKTGCEQLLASIQKEKQL*" /label="yfkJ CDS" gene 786229..786699 /gene="yfkJ" /locus_tag="BSU_07880" /old_locus_tag="BSU07880" /label="yfkJ gene" CDS 786717..787037 /gene="yfkI" /locus_tag="BSU_07890" /old_locus_tag="BSU07890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15995210" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388670.1" /db_xref="EnsemblGenomes-Gn:BSU07890" /db_xref="EnsemblGenomes-Tr:CAB12618" /db_xref="SubtiList:BG12925" /db_xref="UniProtKB/Swiss-Prot:O34418" /translation="MNNERLMLKGIFLGAAAGAALSLLHKPTRQACGMRWLTCKHKLS LYKSNPELLKNTVITKVDEAKKLARTLSKEVDFVNQQVKELKKTTPQVMELVQETKEH FSKK*" /label="yfkI CDS" gene 786717..787037 /gene="yfkI" /locus_tag="BSU_07890" /old_locus_tag="BSU07890" /label="yfkI gene" CDS 787061..787888 /gene="rbn" /locus_tag="BSU_07900" /old_locus_tag="BSU07900" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222749, 12794188, 15849754, 16850406, 15764599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease BN" /protein_id="NP_388671.1" /db_xref="EnsemblGenomes-Gn:BSU07900" /db_xref="EnsemblGenomes-Tr:CAB12619" /db_xref="GOA:O34437" /db_xref="InterPro:IPR017039" /db_xref="SubtiList:BG12924" /db_xref="UniProtKB/Swiss-Prot:O34437" /translation="MSFLKELFSRYTLHEGQSKSAELAYFFLLSLFPFLIFMLTLTAY LPLSTDDVLGVIEQYAPASAMSLVESITHQTLNNRNGGLLSFGIIAALWSASNGMNAI VRSLNHAYDVEENRSFIIVRLTSIFLTIAMVFTILVALLLPVFGREIGRLASDFVGAS DLFLSVWAAIRWGVSPLVLLIVFSALYVIAPNKKLSLRFVMPGAVFATIGWIIVSTLF SFYVSTFANYSATYGSIGGIIVLMIWFYLSGILIILGGEINALLHKRKKLPDENPYH* " /label="rbn CDS" gene 787061..787888 /gene="rbn" /locus_tag="BSU_07900" /old_locus_tag="BSU07900" /label="rbn gene" promotor_-35 787867..787873 /Source="Nicolas_upshift_promotors" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 787888..787899 /Source="Nicolas_upshift_promotors" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 787906..788062 /Source="Nicolas_S_feature" /locus_tag="new_863681_863837" /HighExp="S8, Etha, S6, Salt, S7, S5, ferm, nit, BT, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99976299999999996" /TUshortSig="SigGF, SigA, SigB" /TUshortPSig="0.974, 0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S275" upshifts 787906 /Source="Nicolas_upshifts" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(787938) /Source="Nicolas_upshifts" /id="D393" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.22239" /MaxDrop="3.61507" /score="-5.45682213" /energy="-3" /TU="NA" /idTUdmin="U606" /TUdmin=440 /isTUend="FALSE" /label="downshifts" downshifts 788037 /Source="Nicolas_upshifts" /id="D394" /incds=0 /nref=144 /ntot=253 /MaxReadThrough="1.4253" /MaxDrop="6.85849" /score="25.8200126" /energy="-17.9" /TU="NA" /idTUdmin="U603" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(788087..789262) /gene="yfkF" /locus_tag="BSU_07910" /old_locus_tag="BSU07910" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388672.1" /db_xref="EnsemblGenomes-Gn:BSU07910" /db_xref="EnsemblGenomes-Tr:CAB12620" /db_xref="GOA:O34929" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12923" /db_xref="UniProtKB/Swiss-Prot:O34929" /translation="MSRFHFFILVLLVSISGFSQGMLLPVISIIFETNGESAAINGLH ATGLYIGVLLASPFMEAPLRKLGFKPLIVMGGSIVILSLFGFIWLQSVWVWFLLRLFI GIGDHMLHFSTQTWVTSMSSKQNRGRNLSIYGLSFGLGFAAGPFMVPLVKLSPSLPFI VSGCISLFAWLFVFFLQNAYPETSPHETKSDNSFRRFYQAMLFGWVAFMPTFGYGFLE TALNGSFPVYALRLGISVDAVAIILPAFAIGSIIFQFPLGILSDKYGRRNVLLVILLT GALCFFIAGVFPSPYVIGGCFFIAGMAVGSTFTLGISYMTDLLPPHLLPAGNLLCGIT FSLGSILGPVAGGWYMQTFESANLFYFITLTLSSVWLALVLGKPKSWSPAETYSSSS* " /label="yfkF CDS" gene complement(788087..789262) /gene="yfkF" /locus_tag="BSU_07910" /old_locus_tag="BSU07910" /label="yfkF gene" downshifts complement(788092) /Source="Nicolas_upshifts" /id="D395" /incds=0 /nref=1 /ntot=97 /MaxReadThrough="0.37084" /MaxDrop="3.28031" /score="3.2266059" /energy="-14.1" /TU="NA" /idTUdmin="U606" /TUdmin=286 /isTUend="FALSE" /label="downshifts" promotor_-35 788699..788705 /Source="Nicolas_upshift_promotors" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 788721..788739 /Source="Nicolas_upshift_promotors" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 788725..789378 /Source="Nicolas_S_feature" /locus_tag="new_864500_865153" /HighExp="Etha, M9-stat, Salt, Sw, Gly, B60, Heat, LPhT, HiTm, T0.30H" /AntisenseName="yfkF" /AntisenseCor="-0.18505347560608301" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S276" upshifts 788725 /Source="Nicolas_upshifts" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(789287..789306) /Source="Nicolas_upshift_promotors" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(789302) /Source="Nicolas_upshifts" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(789320..789327) /Source="Nicolas_upshift_promotors" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 789368..789373 /Source="Nicolas_upshift_promotors" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 789380 /Source="Nicolas_upshifts" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 789388..789406 /Source="Nicolas_upshift_promotors" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 789430..790485 /gene="chaA" /locus_tag="BSU_07920" /old_locus_tag="BSU07920" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19543710, 23798403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19543710, 23798403; Product type t: transporter" /codon_start=1 /transl_table=11 /product="H+/Ca2+ antiporter" /protein_id="NP_388673.1" /db_xref="EnsemblGenomes-Gn:BSU07920" /db_xref="EnsemblGenomes-Tr:CAB12621" /db_xref="GOA:O34840" /db_xref="InterPro:IPR004713" /db_xref="InterPro:IPR004798" /db_xref="InterPro:IPR004837" /db_xref="PDB:4KJR" /db_xref="PDB:4KJS" /db_xref="SubtiList:BG12922" /db_xref="UniProtKB/Swiss-Prot:O34840" /translation="MNRIFFILVAAGVPLSVIGSLMHWPSAVLFAVYCVTIIALASYM GRATESLSIIAGPRIGGLLNATFGNAVELIISLFALKEGLTGIVLASLTGSVLGNLLL VAGLSFFVGGLKYKRQEFNIHDARHNSGLLIFAIIVAFVIPEVFSVGMGNASKLNLSI GISIIMILLYVAALYFKLVTHRGVYQPNNAAQTEEEEEPEWSGKVATIVLFAATIVVA YISENLVHTFHSVAEQFGWSELFIGVIIVAIVGNAAEHASAIIMAFKNKMDIAVEIAV GSTLQIAMFVAPVLVICSIFFPTSMPLVFTLPELVAMVSAVLLMIAISNDGDSNWFEG ATLLAAYVIMAIGFFLL*" /label="chaA CDS" gene 789430..790485 /gene="chaA" /locus_tag="BSU_07920" /old_locus_tag="BSU07920" /label="chaA gene" promotor_-35 790499..790505 /Source="Nicolas_upshift_promotors" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 790520..790531 /Source="Nicolas_upshift_promotors" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 790524 /Source="Nicolas_upshifts" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="upshifts" CDS 790556..791350 /gene="yfkD" /locus_tag="BSU_07930" /old_locus_tag="BSU07930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19543710" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388674.1" /db_xref="EnsemblGenomes-Gn:BSU07930" /db_xref="EnsemblGenomes-Tr:CAB12622" /db_xref="InterPro:IPR025548" /db_xref="SubtiList:BG12921" /db_xref="UniProtKB/Swiss-Prot:O34579" /translation="MMKKLFHSTLIVLLFFSFFGVQPIHAKKQFKVPNSVASISKENT YPNASQDQPMLQPSKLAKELLDHSEVKIENPHLIKMLNESNISGTPLAVGYRATIFLG KWALGYESNETVANWEYKKINTNRADNRGGKETAEMHYAQEQQYRVKGGLTAKVPNAE DVKSMMMQKAMKKTNLPLAFETVIGAGTKRDQIYKVAPKKIGYLHAYAPAVNEKGKVT YGEVYLVLKGNKRKLVVKNVTSQGIGAWIPVQDHVTFGFQLSSLPR*" /label="yfkD CDS" gene 790556..791350 /gene="yfkD" /locus_tag="BSU_07930" /old_locus_tag="BSU07930" /label="yfkD gene" downshifts 791338 /Source="Nicolas_upshifts" /id="D396" /incds=0 /nref=41 /ntot=100 /MaxReadThrough="0.82657" /MaxDrop="5.7252" /score="28.7014976" /energy="-9.5" /TU="NA" /idTUdmin="U605" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(791389..792231) /gene="mscC" /locus_tag="BSU_07940" /old_locus_tag="BSU07940" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17665170, 18310427, 19252899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17665170, 18310427, 19252899; Product type t: transporter" /codon_start=1 /transl_table=11 /product="mechanosensitive ion channel" /protein_id="NP_388675.1" /db_xref="EnsemblGenomes-Gn:BSU07940" /db_xref="EnsemblGenomes-Tr:CAB12623" /db_xref="GOA:O35043" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="SubtiList:BG12920" /db_xref="UniProtKB/Swiss-Prot:O35043" /translation="MRMKETLTEIFQNKIVDILLVAVILWIGVFIINRLVQLFFKRTD FIEEKKEKTIESLVRSVTQYTATIGFIFYVISLFVHDFGKILAGAGVAGIVIGFGAQS LIKDVLAGVFLIYERQLHKGDYVTVNNLFNGTVEEIGLRSLQIREWSGKLLTISNGEV RQIENYNIDFMRITESFLISFKEDPDRVYSVLEEACDMLNEELRDSLKRDEFGNPTEP FQIHGITALNKINRGVEFTVKGMVKDDDYFSASLAVRRVLVRQLYQNNVQMLEEAVRI ERTQ*" /label="mscC CDS" gene complement(791389..792231) /gene="mscC" /locus_tag="BSU_07940" /old_locus_tag="BSU07940" /label="mscC gene" downshifts complement(791391) /Source="Nicolas_upshifts" /id="D397" /incds=0 /nref=58 /ntot=230 /MaxReadThrough="1.96922" /MaxDrop="4.8789" /score="23.5281308" /energy="-9.8" /TU="NA" /idTUdmin="U609" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(792232..793353) /gene="yfkA" /locus_tag="BSU_07955" /old_locus_tag="BSU07955" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative Fe-S oxidoreductase, radical SAM superfamily" /protein_id="NP_388677.2" /db_xref="EnsemblGenomes-Gn:BSU07955" /db_xref="EnsemblGenomes-Tr:CAB12625" /db_xref="GOA:O34400" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR014866" /db_xref="InterPro:IPR031004" /db_xref="InterPro:IPR034395" /db_xref="SubtiList:BG12918" /db_xref="UniProtKB/Swiss-Prot:O34400" /translation="MTQNTKLRPITPEFDPWEAYMDVDQYGDMQLTNVEFTTTTLCNM RCEHCAVGYTLQPKDPNALPIDLLLKRLEEIPRLRSISITGGEPMLSLKSVKEYVVPL LKYAHERGVRTQINSNLTLDIERYEWIIPYLDVLHISHNWGTVEDFAEIGFAMMDRKP TFEQRARYFEKMIENSRTLVDAGVMVSAETMLNKRTLPHIEHIHRQITEDMKCQRHEV HPMYPSDFASALESLSLKEMRQAIHRLLDIRDENTWMLFGTLPFYACSPDEDDQKLLR RLRAAKNVTVRNDPDGRSRLNVNIFDGNIIVTDFGDTPPLGNIQTDSLPSAYEKWRET KLAKELSCHCPNVRCLGPNVLVKNSYYQDTDFTKRQARS*" /label="yfkA CDS" gene complement(792232..793353) /gene="yfkA" /locus_tag="BSU_07955" /old_locus_tag="BSU07955" /label="yfkA gene" promotor_-10 complement(793394..793413) /Source="Nicolas_upshift_promotors" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(793412) /Source="Nicolas_upshifts" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(793429..793433) /Source="Nicolas_upshift_promotors" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 793441..793448 /Source="Nicolas_upshift_promotors" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 793462..793481 /Source="Nicolas_upshift_promotors" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 793472 /Source="Nicolas_upshifts" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="upshifts" CDS 793498..793683 /gene="yfjT" /locus_tag="BSU_07970" /old_locus_tag="BSU07970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388678.1" /db_xref="EnsemblGenomes-Gn:BSU07970" /db_xref="EnsemblGenomes-Tr:CAB12626" /db_xref="SubtiList:BG12916" /db_xref="UniProtKB/Swiss-Prot:O35041" /translation="MGNAVNNKDQQIDYLKNRLDMFMNVIDSLDPEATDVEDIDRLIS MLDDLEAKYERFKKDWE*" /label="yfjT CDS" gene 793498..793683 /gene="yfjT" /locus_tag="BSU_07970" /old_locus_tag="BSU07970" /label="yfjT gene" downshifts 793662 /Source="Nicolas_upshifts" /id="D398" /incds=0 /nref=15 /ntot=177 /MaxReadThrough="3.03457" /MaxDrop="3.24661" /score="14.1645187" /energy="-6.4" /TU="U610" /idTUdmin="U610" /TUdmin="-559" /isTUend="FALSE" /label="downshifts" promotor_-35 793726..793732 /Source="Nicolas_upshift_promotors" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 793738 /Source="Nicolas_upshifts" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 793747..793758 /Source="Nicolas_upshift_promotors" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 793784..794575 /gene="pdaA" /locus_tag="BSU_07980" /old_locus_tag="BSU07980" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 15687192" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 15687192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported peptidoglycan N-acetylmuramic acid deacetylase" /protein_id="NP_388679.1" /db_xref="EnsemblGenomes-Gn:BSU07980" /db_xref="EnsemblGenomes-Tr:CAB12627" /db_xref="GOA:O34928" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014235" /db_xref="PDB:1NY1" /db_xref="PDB:1W17" /db_xref="PDB:1W1A" /db_xref="PDB:1W1B" /db_xref="SubtiList:BG12915" /db_xref="UniProtKB/Swiss-Prot:O34928" /translation="MKWMCSICCAAVLLAGGAAQAEAVPNEPINWGFKRSVNHQPPDA GKQLNSLIEKYDAFYLGNTKEKTIYLTFDNGYENGYTPKVLDVLKKHRVTGTFFVTGH FVKDQPQLIKRMSDEGHIIGNHSFHHPDLTTKTADQIQDELDSVNEEVYKITGKQDNL YLRPPRGVFSEYVLKETKRLGYQTVFWSVAFVDWKINNQKGKKYAYDHMIKQAHPGAI YLLHTVSRDNAEALDDAITDLKKQGYTFKSIDDLMFEKEMRLPSL*" /label="pdaA CDS" gene 793784..794575 /gene="pdaA" /locus_tag="BSU_07980" /old_locus_tag="BSU07980" /label="pdaA gene" downshifts 794573 /Source="Nicolas_upshifts" /id="D399" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="2.12067" /MaxDrop="3.4013" /score="14.4741934" /energy="-10.2" /TU="NA" /idTUdmin="U611" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(794613..795473) /gene="yfjR" /locus_tag="BSU_07990" /old_locus_tag="BSU07990" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative beta-hydroxyacid dehydrogenase" /protein_id="NP_388680.2" /db_xref="EnsemblGenomes-Gn:BSU07990" /db_xref="EnsemblGenomes-Tr:CAB12628" /db_xref="GOA:O34969" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR015815" /db_xref="InterPro:IPR029154" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12914" /db_xref="UniProtKB/Swiss-Prot:O34969" /translation="MKIAVIGLGNMGQPIARNVLQAGYELTVYNRTKQKTEDLVTEGA QAADTPRLAAKSADIVITMLADDDSVSTVTFGEDGLLEGLAENGIHISMSTISVEFSE KLAAAHAEKGQFFLAAPVLGRPDAAAKAALRIITAGPAEAKQAAKPLLDSLSQQIFDV GEESKTANAAKISINFLLVSMLEALSESFLMMEKYGLEQKQFLEIASALFGSPVYQNY GTIMAEQKFEPAGFKMSLGLKDTNLALAAAKRVSANLPLAELAKSHFESGIEKGFGDL DWAALIKCIK*" /label="yfjR CDS" gene complement(794613..795473) /gene="yfjR" /locus_tag="BSU_07990" /old_locus_tag="BSU07990" /label="yfjR gene" downshifts complement(794627) /Source="Nicolas_upshifts" /id="D400" /incds=0 /nref=15 /ntot=193 /MaxReadThrough="2.61589" /MaxDrop="3.98341" /score="-1.3382901" /energy="-12.1" /TU="NA" /idTUdmin="U612" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(795493..795512) /Source="Nicolas_upshift_promotors" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(795507) /Source="Nicolas_upshifts" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(795528..795531) /Source="Nicolas_upshift_promotors" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(795572..796531) /gene="yfjQ" /locus_tag="BSU_08000" /old_locus_tag="BSU08000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14563871, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="divalent cation (octahedral coordination) transporter" /protein_id="NP_388681.1" /db_xref="EnsemblGenomes-Gn:BSU08000" /db_xref="EnsemblGenomes-Tr:CAB12629" /db_xref="GOA:O31543" /db_xref="InterPro:IPR002523" /db_xref="InterPro:IPR004488" /db_xref="SubtiList:BG12913" /db_xref="UniProtKB/Swiss-Prot:O31543" /translation="MINITAITTEHQLLKNIPIERVEQPDIAWYWVDFYGPEDTETAL LRDFFHFHPLAIEDCFQHMQRPKLDHYDGYRFYVIHALNKETLETEEVDIFQGEKFVV TFHLHETPGIAKVRERLYASPDILKKGPGHISYMIMDQLVDEYFPLVYKIEDRLNEIE ESRPHKTYGTLMNEVFDLRTDLLHLRRTIIPMRDLLYRILSLDHVKEQRETKAYFSDI YDHLLKLSEIVESNRDMTSDLRDSYVTLNSNRMNAIMMTLTIVSTIFIPLTFIAGVYG MNFDFMPELHWKYGYFAVLGLMAALVIGMLIWFVHKGWFNIFK*" /label="yfjQ CDS" gene complement(795572..796531) /gene="yfjQ" /locus_tag="BSU_08000" /old_locus_tag="BSU08000" /label="yfjQ gene" downshifts complement(795595) /Source="Nicolas_upshifts" /id="D401" /incds=0 /nref=137 /ntot=224 /MaxReadThrough="2.29296" /MaxDrop="4.2496" /score="10.2736001" /energy="-7.5" /TU="NA" /idTUdmin="U613" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(796542..796561) /Source="Nicolas_upshift_promotors" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(796545) /Source="Nicolas_upshifts" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(796577..796580) /Source="Nicolas_upshift_promotors" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 796592..796596 /Source="Nicolas_upshift_promotors" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 796610..796629 /Source="Nicolas_upshift_promotors" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 796619 /Source="Nicolas_upshifts" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="upshifts" CDS 796650..797513 /gene="yfjP" /locus_tag="BSU_08010" /old_locus_tag="BSU08010" /EC_number="3.2.2.21" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA-3-methyladenine glycosylase" /protein_id="NP_388682.1" /db_xref="EnsemblGenomes-Gn:BSU08010" /db_xref="EnsemblGenomes-Tr:CAB12630" /db_xref="GOA:O31544" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR023170" /db_xref="SubtiList:BG12912" /db_xref="UniProtKB/Swiss-Prot:O31544" /translation="MWKEKVSVTPPYHFDRVLDRLSLDPLNAVDREAREVRVPIRNQA GDVCIVKVQALGHAGEPEFLVSGETDQGEMMKEIKRIFQWENHLQHVLDHFSKTSLSA IFEEHAGTPLVLDYSVYNCMMKCIIHQQLNLSFAYTLTERFVHAFGEQKDGVWCYPKP ETIAELDYQDLRDLQFSMRKAEYTIDTSRMIAEGTLSLSELPHMADEDIMKKLIKIRG IGPWTVQNVLMFGLGRPNLFPLADIGLQNAIKRHFQLDDKPAKDVMLAMSKEWEPYLS YASLYLWRSIE*" /label="yfjP CDS" gene 796650..797513 /gene="yfjP" /locus_tag="BSU_08010" /old_locus_tag="BSU08010" /label="yfjP gene" S_feature 797514..797626 /Source="Nicolas_S_feature" /locus_tag="new_873289_873401" /HighExp="BC, M40t90, LBGtran, C90, M9-stat, M0t90, Lbtran, Sw, M40t45, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S277" CDS 797627..799027 /gene="yfjO" /locus_tag="BSU_08020" /old_locus_tag="BSU08020" /EC_number="2.1.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA methyltransferase" /protein_id="NP_388683.1" /db_xref="EnsemblGenomes-Gn:BSU08020" /db_xref="EnsemblGenomes-Tr:CAB12631" /db_xref="GOA:O31545" /db_xref="InterPro:IPR001566" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR010280" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030390" /db_xref="InterPro:IPR030391" /db_xref="SubtiList:BG12911" /db_xref="UniProtKB/Swiss-Prot:O31545" /translation="MNQQKKQAPVELKVGQTFPLTIKRLGINGEGVGYFKKKVVFVPG ALPGEEVVVQATKVQPKFSEGRIKKIRKASEHRVAPPCPVYEQCGGCQLQHLAYSQQL REKRDIVIQSLERHTKFKVENMEIKETIGMDNPWNYRNKSQFQIGRSQSGSIIAGLYG LDSHDIVPIKDCIVQHPATNKTTGIVRRILEDFNVSVYNERKRKGDVRTIVTRVGFET GEVQVVLVTAKETLPHKEEIVKAIQKRLPEVKSIIQNVNGAKTSVIFGEKTKQLAGKT VIQEVLGDVSFELSARAFFQLNPEQTVKLYDEVKKAAQLTGKEKVVDAYCGVGTIGMW VADGAKEVRGMDVIKESIDDAKKNAKKHGMANATYVTGTAEHWLPKWTKEGFRPDVVI VDPPRTGCDSTFLDTIKKVKPKRFVYVSCNPSTLAKDLQTLSKDYRVDYIQPVDMFPQ TAHVEAVARLVLKSSN*" /label="yfjO CDS" gene 797627..799027 /gene="yfjO" /locus_tag="BSU_08020" /old_locus_tag="BSU08020" /label="yfjO gene" downshifts 799039 /Source="Nicolas_upshifts" /id="D402" /incds=0 /nref=198 /ntot=251 /MaxReadThrough="1.18186" /MaxDrop="5.19313" /score="11.8630961" /energy="-12.6" /TU="NA" /idTUdmin="U614" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 799333..799340 /Source="Nicolas_upshift_promotors" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 799356..799375 /Source="Nicolas_upshift_promotors" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 799362 /Source="Nicolas_upshifts" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="upshifts" S_feature 799369..799652 /Source="Nicolas_S_feature" /locus_tag="new_875144_875427" /HighExp="M9-stat, T1.30H, T0.30H, T2.0H, LoTm, T3.0H, T3.30H, T1.0H, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.69102300000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S278" CDS 799653..799919 /gene="yfzA" /locus_tag="BSU_08029" /old_locus_tag="BSU08029" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097694.1" /db_xref="EnsemblGenomes-Gn:BSU08029" /db_xref="EnsemblGenomes-Tr:CAX52581" /db_xref="GOA:C0H3X6" /db_xref="InterPro:IPR025627" /db_xref="UniProtKB/Swiss-Prot:C0H3X6" /translation="MDKVYKRSWFQTFLAFLVSQLYFNFVELTGWGPKYREMNGFPAN IVELDFFQTYLSFYDNPWFNIITVFLGVFTIIQIITGITKDIRN*" /label="yfzA CDS" gene 799653..799919 /gene="yfzA" /locus_tag="BSU_08029" /old_locus_tag="BSU08029" /label="yfzA gene" promotor_-10 complement(799867..799886) /Source="Nicolas_upshift_promotors" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(799885) /Source="Nicolas_upshifts" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(799901..799904) /Source="Nicolas_upshift_promotors" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 799920..800401 /Source="Nicolas_S_feature" /locus_tag="new_875695_876176" /HighExp="G180, Paraq, H2O2, G135, Oxctl, G150, C30, LoTm, S8, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S279" promotor_-35 800372..800375 /Source="Nicolas_upshift_promotors" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 800392..800411 /Source="Nicolas_upshift_promotors" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 800403..800650 /Source="Nicolas_S_feature" /locus_tag="new_876178_876425" /HighExp="H2O2, G180, Paraq, G150, G135, Oxctl, dia15, LBGstat, LBGexp, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S280" upshifts 800403 /Source="Nicolas_upshifts" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="upshifts" CDS 800651..801628 /gene="dusC" /locus_tag="BSU_08030" /old_locus_tag="BSU08030" /EC_number="1.-.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11983710, 25902496; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-dihydrouridine synthase 2" /protein_id="NP_388684.1" /db_xref="EnsemblGenomes-Gn:BSU08030" /db_xref="EnsemblGenomes-Tr:CAB12632" /db_xref="GOA:O31546" /db_xref="InterPro:IPR001269" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018517" /db_xref="InterPro:IPR024036" /db_xref="InterPro:IPR035587" /db_xref="SubtiList:BG12910" /db_xref="UniProtKB/Swiss-Prot:O31546" /translation="MTENFWRELPRPFFVLAPMEDVTDVVFRHVVSEAGRPDVFFTEF TNSESYCHPDGKDSVRGRLTFTEDEQPIVAHIWGDKPENFRKMSIGMAELGFKGLDIN MGCPVPNVAGNGKGSGLICRPAVAAELIQAAKAGGLPVSVKTRLGYTDVDEWREWLTH ILKQDIANLSIHLRTRAEMSKVDAHWELIPEIKKLRDEVAPDTLLTINGDIPDRQTGL KLAEQYGVDGIMIGRGIFTNPFAFEKEPKEHSSKELLDLLRLHLDLHDEYSKEEARPY KPLPRFFKIYLRGFRGASELRNQCMNTKSTDEVRALLDDFERKYLDGIE*" /label="dusC CDS" gene 800651..801628 /gene="dusC" /locus_tag="BSU_08030" /old_locus_tag="BSU08030" /label="dusC gene" S_feature 801629..801721 /Source="Nicolas_S_feature" /locus_tag="new_877404_877496" /HighExp="G135, G180, Paraq, G150, H2O2, LBGexp, aero, dia0, Oxctl, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S281" downshifts 801678 /Source="Nicolas_upshifts" /id="D403" /incds=0 /nref=86 /ntot=218 /MaxReadThrough="3.30163" /MaxDrop="4.0519" /score="11.8630961" /energy="-12.6" /TU="U617" /idTUdmin="U618" /TUdmin="-1211" /isTUend="FALSE" /label="downshifts" promotor_-35 801762..801768 /Source="Nicolas_upshift_promotors" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 801780..801799 /Source="Nicolas_upshift_promotors" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 801789 /Source="Nicolas_upshifts" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="upshifts" CDS 801824..802276 /gene="yfjM" /locus_tag="BSU_08040" /old_locus_tag="BSU08040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388685.1" /db_xref="EnsemblGenomes-Gn:BSU08040" /db_xref="EnsemblGenomes-Tr:CAB12633" /db_xref="SubtiList:BG12909" /db_xref="UniProtKB/Swiss-Prot:O31547" /translation="MKRLCIIPCGKKKIWDVQPDAGPVRAEDAYLSPFHQACERYAKT FFDEWVILSAKHGFLRPDDLVSGNYDVTFGTGHPEIMTADELRRQFHEKGFSDIEELV MLGGKKYRSVLNAVIGEHQHISWPLSSYKGIGYMLQALNRAVEEKHEL*" /label="yfjM CDS" gene 801824..802276 /gene="yfjM" /locus_tag="BSU_08040" /old_locus_tag="BSU08040" /label="yfjM gene" CDS 802306..802995 /gene="yfjL" /locus_tag="BSU_08050" /old_locus_tag="BSU08050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388686.1" /db_xref="EnsemblGenomes-Gn:BSU08050" /db_xref="EnsemblGenomes-Tr:CAB12634" /db_xref="InterPro:IPR020523" /db_xref="SubtiList:BG11034" /db_xref="UniProtKB/Swiss-Prot:P40773" /translation="MKKLVFGLLAIVLFGCGLYIYHVWFGDPFSKNAAEQKLVSYVKQ TYPKKEIKITNGVYNAKTSEYVFEATSQSHRYPMCTKGFLHPKVTCDGIEEAYTESVA KHVNEEATKAIEADLKKAVPRFIKADAALSIENGQFTLDTKWNKKLAEKAPMSMTIQL DASGLSKTDAAKMAETVRKTLNEKGYTYSNGTIDCMQKDGDGGIGYVKYSIDFLSKAA IQSNDAEELGS*" /label="yfjL CDS" gene 802306..802995 /gene="yfjL" /locus_tag="BSU_08050" /old_locus_tag="BSU08050" /label="yfjL gene" downshifts 803000 /Source="Nicolas_upshifts" /id="D404" /incds=0 /nref=31 /ntot=205 /MaxReadThrough="0.02745" /MaxDrop="3.61164" /score="23.9796437" /energy="-9" /TU="NA" /idTUdmin="U617" /TUdmin=1 /isTUend="TRUE" /label="downshifts" misc_feature 803172..803190 /Source="Nicolas_upshift_promotors" /id="U619" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.878121878121878" /psig="0.878121878121878" /xcortree=351 /SigmaFactorBS="caaactgtctccaaagtgaagatgagaagactgattttacgg gctcaaaagacTGGCACACTTCTTGCATTTataatggtgaaccctaaatagaaggagg c" /listShort="acoA, acoB, acoC, acoL, acoR, sspH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 803179 /Source="Nicolas_upshifts" /id="U619" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.878121878121878" /psig="0.878121878121878" /xcortree=351 /SigmaFactorBS="caaactgtctccaaagtgaagatgagaagactgattttacgg gctcaaaagacTGGCACACTTCTTGCATTTataatggtgaaccctaaatagaaggagg c" /listShort="acoA, acoB, acoC, acoL, acoR, sspH" /GFF_Attribute="listLong" /label="upshifts" CDS 803227..804228 /gene="acoA" /locus_tag="BSU_08060" /old_locus_tag="BSU08060" /EC_number="1.1.1.303" /EC_number="2.3.1.190" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10368162, 11274109, 22714279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10368162, 11274109, 22714279; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E1 component (TPP-dependent alpha subunit)" /protein_id="NP_388687.1" /db_xref="EnsemblGenomes-Gn:BSU08060" /db_xref="EnsemblGenomes-Tr:CAB12635" /db_xref="GOA:O31404" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG12558" /db_xref="UniProtKB/Swiss-Prot:O31404" /translation="MKLLKREGLSLTEEKALWMYQKMLEIRGFEDKVHELFAQGVLPG FVHLYAGEEAVAVGVCAHLHDGDSITSTHRGHGHCIAKGCDLDGMMAEIFGKATGLCK GKGGSMHIADLDKGMLGANGIVGGGFTLACGSALTAKYKQTKNVSVCFFGDGANNQGT FHEGLNLAAVWNLPVVFVAENNGYGEATPFEYASACDSIADRAAAYNMPGVTVDGKDI LAVYQAAEEAIERARNGGGPSLIECMTYRNYGHFEGDAQTYKTKDERVEHLEEKDAIQ GFKNYLLKETDANKLSDIEQRVSESIEKAVSFSEDSPYPKDSELLTDVYVSYEKGGM* " /label="acoA CDS" gene 803227..804228 /gene="acoA" /locus_tag="BSU_08060" /old_locus_tag="BSU08060" /label="acoA gene" CDS 804232..805260 /gene="acoB" /locus_tag="BSU_08070" /old_locus_tag="BSU08070" /EC_number="1.1.1.303" /EC_number="2.3.1.190" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11274109, 10368162" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 10368162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E1 component (TPP-dependent beta subunit)" /protein_id="NP_388688.1" /db_xref="EnsemblGenomes-Gn:BSU08070" /db_xref="EnsemblGenomes-Tr:CAB12636" /db_xref="GOA:O34591" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG12559" /db_xref="UniProtKB/Swiss-Prot:O34591" /translation="MARVISMSDAINEAMKLAMRKDENVLLIGEDVAGGAAVDHLQDD EAWGGVLGVTKGLVQEFGRTRVLDTPISEAGYMGAAMAAASTGLRPIAELMFNDFIGT CFDQVINQGAKFRYMFGGKAQVPITVRTTYGAGFRAAAQHSQSLYGLFTSIPGLKTVV PSNPYDAKGLLLAAIEDNDPVFFFEDKTSYNMKGEVPEDYYTIPLGKADIKREGNDVT LFAVGKQVNTALEAAAQLSERGIEAEVLDPRSLSPLDEDAIFTSLEKTNRLIIIDEAN PRCSIATDIAALVADKGFDLLDAPIKRITAPHTPVPFSPVLEDQYLPTPDKIVSVTLE LLGEPALN*" /label="acoB CDS" gene 804232..805260 /gene="acoB" /locus_tag="BSU_08070" /old_locus_tag="BSU08070" /label="acoB gene" CDS 805274..806470 /gene="acoC" /locus_tag="BSU_08080" /old_locus_tag="BSU08080" /EC_number="2.3.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10368162, 11274109" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10368162, 11274109; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E2 component (dihydrolipoamide acetyltransferase)" /protein_id="NP_388689.1" /db_xref="EnsemblGenomes-Gn:BSU08080" /db_xref="EnsemblGenomes-Tr:CAB12637" /db_xref="GOA:O31550" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG12560" /db_xref="UniProtKB/Swiss-Prot:O31550" /translation="MAVKVVMPKLGMAMKQGEVSIWNKKVGDPVEKGESIASIQSEKI EMEIEAPEKGTLIDIKVKEGEEVPPGTAICYIGDANESVQEEAGAPVAEDNMPQAVQP VKQENKPAASKKDRMKISPVARKIAEKAGLDLKQLKGTGPGGRIVKDDVTKALAEQKK DQAKPVSEQKAQEIPVTGMRKVIAARMQESLANSAQLTITMKADITKLATLQKQLSPT AEERYGTKLTITHFVSRAAVLALQAHPVLNSFYQNERIITHPHVHLGMAVALENGLVV PVIRHAEKLSLIELAQSISENAKKAREGRAGSEELQGSTFSITNLGAFGVEHFTPILN PPETGILGIGASYDTPVYQGEEIVRSTILPLSLTFDHRACDGAPAAAFLKAMKTYLEE PAALIL*" /label="acoC CDS" gene 805274..806470 /gene="acoC" /locus_tag="BSU_08080" /old_locus_tag="BSU08080" /label="acoC gene" downshifts complement(805275) /Source="Nicolas_upshifts" /id="D405" /incds=0 /nref=8 /ntot=46 /MaxReadThrough="0.481579999999999" /MaxDrop="4.16582" /score="-0.0231058321" /energy="-9.9" /TU="NA" /idTUdmin="U623" /TUdmin=4796 /isTUend="FALSE" /label="downshifts" CDS 806491..807867 /gene="acoL" /locus_tag="BSU_08090" /old_locus_tag="BSU08090" /EC_number="1.8.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11274109, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E3 component (dihydrolipoamide dehydrogenase)" /protein_id="NP_388690.1" /db_xref="EnsemblGenomes-Gn:BSU08090" /db_xref="EnsemblGenomes-Tr:CAB12638" /db_xref="GOA:O34324" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12561" /db_xref="UniProtKB/Swiss-Prot:O34324" /translation="MTLAIIGGGPAGYAAAVSAAQQGRNVLLIDKGKLGGTCLNEGCI PTKSLLESANVLDKIKHADSFGIELPAGAISVDWSKMQSRKQQVVSQLVQGVQYLMKK NQIQVVKGTASFLSERKLLIEGENGKEIREADQVLIASGSEPIELPFAPFDGEWILDS KDALSLSEIPSSLVIVGGGVIGCEYAGLFARLGSQVTIIETADRLIPAEDEDIARLFQ EKLEEDGVEVHTSSRLGRVDQTAKTAIWKSGQREFKTKADYVLVAIGRKPRLDGLQLE QAGVDFSPKGIPVNGHMQTNVPHIYACGDAIGGIQLAHAAFHEGIIAASHASGRDVKI NEKHVPRCIYTSPEIACIGMTERQARSIYGDVKIGEFSFSANGKALIKQQAEGKVKIM AEPEFGEIVGVSMIGPDVTELIGQAAAIMNGEMTADMAEHFIAAHPTLSETLHEALLS TIGLAVHA*" /label="acoL CDS" gene 806491..807867 /gene="acoL" /locus_tag="BSU_08090" /old_locus_tag="BSU08090" /label="acoL gene" downshifts 807861 /Source="Nicolas_upshifts" /id="D406" /incds=0 /nref=27 /ntot=56 /MaxReadThrough="5.75671" /MaxDrop="5.6153" /score="27.0133719" /energy="-14.7" /TU="U619" /idTUdmin="U619" /TUdmin="-2156" /isTUend="FALSE" /label="downshifts" promotor_-35 807914..807921 /Source="Nicolas_upshift_promotors" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 807934..807953 /Source="Nicolas_upshift_promotors" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 807942 /Source="Nicolas_upshifts" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="upshifts" CDS 807983..809800 /gene="acoR" /locus_tag="BSU_08100" /old_locus_tag="BSU08100" /experiment="publication(s) with functional evidences, PMID:11274109, 16944132" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 16944132; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AcoR-acetoin)" /protein_id="NP_388691.1" /db_xref="EnsemblGenomes-Gn:BSU08100" /db_xref="EnsemblGenomes-Tr:CAB12639" /db_xref="GOA:O31551" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG11790" /db_xref="UniProtKB/Swiss-Prot:O31551" /translation="MNSVPNDLQTWKRFVKDGVLDEARLRKRIAESWHRCKKAEVNPY LEKGPKVLQQTELDQQSKKHSFFLTTAKPYLEKLLPAIKEMEMMALLIDSDGVVLALD GHPRALYEAKRINFVEGACWTETAVGTNAIGTALHISEPVAIQGSEHYSIASHLWNCS AAPIHHEDGSLAGVIDISCPAAGAHPHMLGIATAIAYAAERELAAKSREKELELISRF GERAASSVPMVLCNTKQHIISASMPIRTSMPDWQGRHLYELKERGYSIENAVTIGDGG TCFYLSEQKKKKAFRFNGVIGQSGRSQAMLMHLERAAATDASVCLSGETGTGKEVAAR ALHENSERRHGPFVAVNCGAIPSDLIESELFGYAEGAFTGAKRNGYKGAFQKANQGTL FLDEIGEISHSMQVALLRVLQERKITPIGGTKEIPVDIRVIAATHCDLRELAENGKIR EDLFYRLHVYPIELPPLRDRTEDIPDLFEYYKQKNHWPGDLPSDFCNVLKQWKWPGNI RELFNVFERLSIRFPDGRLRDESLPALLEAAGLPASSAEKKPAAAGVLTFREQIQKDM MIKALESAKGNVSQAAKISGIPRSTFYKRLKKFNLSAES*" /label="acoR CDS" gene 807983..809800 /gene="acoR" /locus_tag="BSU_08100" /old_locus_tag="BSU08100" /label="acoR gene" promotor_-35 809801..809807 /Source="Nicolas_upshift_promotors" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 809819 /Source="Nicolas_upshifts" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 809822..809833 /Source="Nicolas_upshift_promotors" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 809854..810033 /gene="sspH" /locus_tag="BSU_08110" /old_locus_tag="BSU08110" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_388692.1" /db_xref="EnsemblGenomes-Gn:BSU08110" /db_xref="EnsemblGenomes-Tr:CAB12640" /db_xref="GOA:O31552" /db_xref="InterPro:IPR012610" /db_xref="SubtiList:BG12917" /db_xref="UniProtKB/Swiss-Prot:O31552" /translation="MNIQRAKEIVESPDMKKVTYNGVPIYIQHVNEETGTARIYPLDE PQEEHEVQLNSLKED*" /label="sspH CDS" gene 809854..810033 /gene="sspH" /locus_tag="BSU_08110" /old_locus_tag="BSU08110" /label="sspH gene" downshifts 810017 /Source="Nicolas_upshifts" /id="D407" /incds=0 /nref=96 /ntot=181 /MaxReadThrough="1.9176" /MaxDrop="6.06509" /score="5.08326573" /energy="-12" /TU="NA" /idTUdmin="U619" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(810069..810398) /gene="yfjF" /locus_tag="BSU_08120" /old_locus_tag="BSU08120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388693.1" /db_xref="EnsemblGenomes-Gn:BSU08120" /db_xref="EnsemblGenomes-Tr:CAB12641" /db_xref="GOA:O31553" /db_xref="InterPro:IPR003844" /db_xref="SubtiList:BG12908" /db_xref="UniProtKB/Swiss-Prot:O31553" /translation="MMLITILLFLAAGLAEIGGGYLVWLWLREAKPAGYGIAGALILI VYGILPTFQSFPSFGRVYAAYGGVFIVLAVLWGWLVDRKTPDLYDWIGAFICLIGVCV ILFAPRG*" /label="yfjF CDS" gene complement(810069..810398) /gene="yfjF" /locus_tag="BSU_08120" /old_locus_tag="BSU08120" /label="yfjF gene" downshifts complement(810083) /Source="Nicolas_upshifts" /id="D408" /incds=0 /nref=96 /ntot=245 /MaxReadThrough="2.05328" /MaxDrop="6.2642" /score="34.1179702" /energy="-15.8" /TU="NA" /idTUdmin="U623" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" CDS complement(810448..810906) /gene="yfjE" /locus_tag="BSU_08130" /old_locus_tag="BSU08130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388694.1" /db_xref="EnsemblGenomes-Gn:BSU08130" /db_xref="EnsemblGenomes-Tr:CAB12642" /db_xref="GOA:O31554" /db_xref="InterPro:IPR035324" /db_xref="SubtiList:BG12907" /db_xref="UniProtKB/Swiss-Prot:O31554" /translation="MSEALTFESKYALLYLGGGLLAMIYGLITFFMAFPAFTSRGNVI FTIKTGPSGEIFLRKRSVLFSEVKRLYMGRHQYSLKGIFFEDIIIEKTDGKIVRIPTW NIITNPLFFEAVERYILPHLNEEAQNNWISQFTEVQRKAYLKEFENHPKL*" /label="yfjE CDS" gene complement(810448..810906) /gene="yfjE" /locus_tag="BSU_08130" /old_locus_tag="BSU08130" /label="yfjE gene" S_feature complement(810907..810999) /Source="Nicolas_S_feature" /locus_tag="new_886682_886774_c" /HighExp="BI, BC, S2, Sw, HiOs, HiTm, S5, ferm, S4, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S282" CDS complement(811000..811557) /gene="yfjD" /locus_tag="BSU_08140" /old_locus_tag="BSU08140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388695.1" /db_xref="EnsemblGenomes-Gn:BSU08140" /db_xref="EnsemblGenomes-Tr:CAB12643" /db_xref="GOA:O31555" /db_xref="InterPro:IPR035324" /db_xref="SubtiList:BG12906" /db_xref="UniProtKB/Swiss-Prot:O31555" /translation="MKNQEIIEVKSKMFLRIWAFVGSAGMGLACLWLFYMGITFQTKY YLLAIPAGFLFTLFCLYLFIIFFPAFTPRGNTIFRIKTGKNGEVFTDKVSVTFTDIKK IEMSRHKFSLKGIFQEDILIQTVDQKTIRIPTWNIIPNPLFFEAVERYILPHLNEEAK SNWIGQFTDIQRSAYLKEFENHPKL*" /label="yfjD CDS" gene complement(811000..811557) /gene="yfjD" /locus_tag="BSU_08140" /old_locus_tag="BSU08140" /label="yfjD gene" promotor_-35 811423..811428 /Source="Nicolas_upshift_promotors" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 811436 /Source="Nicolas_upshifts" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 811443..811461 /Source="Nicolas_upshift_promotors" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 811447..812034 /Source="Nicolas_S_feature" /locus_tag="new_887222_887809" /HighExp="S4, S5, S6, S3, S8, S7, LoTm, T5.0H, T4.0H, Pyr" /AntisenseName="yfjC" /AntisenseCor="9.3643586039105595E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S283" CDS complement(811589..812356) /gene="yfjC" /locus_tag="BSU_08150" /old_locus_tag="BSU08150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14563871" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388696.1" /db_xref="EnsemblGenomes-Gn:BSU08150" /db_xref="EnsemblGenomes-Tr:CAB12644" /db_xref="SubtiList:BG12905" /db_xref="UniProtKB/Swiss-Prot:O31556" /translation="MKQFTISIEELLFCFYSEGFFEQGMALKQAYFPEIEDEQLGALF EAACRSLLAKDAAEYRNHQYRLKDEYCPFIHVLNDADYTVKLSKFNGQGAEQNVSCHV SKFGTYSHELLFDEQVHRITKMESSEGLLAKTDEFLHIIDTEDKRESIVTLTSNEFEK LLEGASDNPSYLKEFLEKHDHQEDVTRFANDLALRKGKMDTLMRLAYGKDNTPEVADM AFVLPGAHHTWLVTGITQNEFSILPAHKDVVNQIISK*" /label="yfjC CDS" gene complement(811589..812356) /gene="yfjC" /locus_tag="BSU_08150" /old_locus_tag="BSU08150" /label="yfjC gene" CDS complement(812368..813591) /gene="yfjB" /locus_tag="BSU_08160" /old_locus_tag="BSU08160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="NP_388697.1" /db_xref="EnsemblGenomes-Gn:BSU08160" /db_xref="EnsemblGenomes-Tr:CAB12645" /db_xref="SubtiList:BG12904" /db_xref="UniProtKB/Swiss-Prot:O31557" /translation="MSGNIAVDPDKLEQLANDVVTELTDMENKYKDLHVELGQMILQC DPRYSSCFSGVGDAWSSGKALVTKLSDNEIFIRKTGDKFVEQDDILRKLYNAYDKYGT MTSLTALMLTQGKYYGLGLTKFVKQPSGLHTAQHSKLLLDISRAVDSSRYQKAARVLL NPKYLLKKTNRPFSDLVHKKFTKYFPQDTVDFSNSVRSYTKGFLNEAGVRSTLKDVGK TGLRFAKGNAITATLITGATETFGAGVKIAENYAKYQDKPEVLKRENAKAVGNAVNNT IFVAGGATAGAVIGGAIGSFAGPVGTVLLGAAGSYIGGVVGEQIAKYTAGFAEKAALK LKEPIHAVVDTAKKGLESAGKVVKSVNDGIDAANKSIHKGIDSAKKGMEKAKKTADSL IHGATHFLKGKFSFG*" /label="yfjB CDS" gene complement(812368..813591) /gene="yfjB" /locus_tag="BSU_08160" /old_locus_tag="BSU08160" /label="yfjB gene" CDS complement(813597..813911) /gene="yfjA" /locus_tag="BSU_08170" /old_locus_tag="BSU08170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388698.1" /db_xref="EnsemblGenomes-Gn:BSU08170" /db_xref="EnsemblGenomes-Tr:CAB12646" /db_xref="InterPro:IPR010310" /db_xref="InterPro:IPR036689" /db_xref="SubtiList:BG12903" /db_xref="UniProtKB/Swiss-Prot:O31558" /translation="MDSYKVIELANKYSAAAEEVRSSKMLLESRLSALGDAWQGKARD SFDQDFEETKAAYDQFEQELLETSQELKAAAVKIEERKAEIARMEELERKAREERHKL GR*" /label="yfjA CDS" gene complement(813597..813911) /gene="yfjA" /locus_tag="BSU_08170" /old_locus_tag="BSU08170" /label="yfjA gene" promotor_-10 complement(813959..813978) /Source="Nicolas_upshift_promotors" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(813972) /Source="Nicolas_upshifts" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(813993..813996) /Source="Nicolas_upshift_promotors" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 814203..814222 /Source="Nicolas_upshift_promotors" /id="U624" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.258741258741259" /psig="0.684315684315684" /xcortree=342 /SigmaFactorBS="cactaaagttgatcaaatgacctaagtgcgccaaacgtgtta cgggacgagctatctCATGGTATAAATGGAATTGTaaacgttatcaaggaggtcgtca t" /listShort="malA, malR, malP, malQ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 814206 /Source="Nicolas_upshifts" /id="U624" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.258741258741259" /psig="0.684315684315684" /xcortree=342 /SigmaFactorBS="cactaaagttgatcaaatgacctaagtgcgccaaacgtgtta cgggacgagctatctCATGGTATAAATGGAATTGTaaacgttatcaaggaggtcgtca t" /listShort="malA, malR, malP, malQ" /GFF_Attribute="listLong" /label="upshifts" CDS 814247..815596 /gene="malA" /locus_tag="BSU_08180" /old_locus_tag="BSU08180" /EC_number="3.2.1.122" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9765262, 10329789, 11489864, 15341727, 15670594, 16707683, 17676871, 20698522" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9765262, 10329789, 11489864, 15341727, 15670594, 16707683, 17676871, 20698522; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-alpha-glucosidase" /protein_id="NP_388699.1" /db_xref="EnsemblGenomes-Gn:BSU08180" /db_xref="EnsemblGenomes-Tr:CAB12647" /db_xref="GOA:P54716" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="PDB:1U8X" /db_xref="SubtiList:BG11839" /db_xref="UniProtKB/Swiss-Prot:P54716" /translation="MKKKSFSIVIAGGGSTFTPGIVLMLLDHLEEFPIRKLKLYDNDK ERQDRIAGACDVFIREKAPDIEFAATTDPEEAFTDVDFVMAHIRVGKYAMRALDEQIP LKYGVVGQETCGPGGIAYGMRSIGGVLEILDYMEKYSPDAWMLNYSNPAAIVAEATRR LRPNSKILNICDMPVGIEDRMAQILGLSSRKEMKVRYYGLNHFGWWTSIQDQEGNDLM PKLKEHVSQYGYIPKTEAEAVEASWNDTFAKARDVQAADPDTLPNTYLQYYLFPDDMV KKSNPNHTRANEVMEGREAFIFSQCDMITREQSSENSEIKIDDHASYIVDLARAIAYN TGERMLLIVENNGAIANFDPTAMVEVPCIVGSNGPEPITVGTIPQFQKGLMEQQVSVE KLTVEAWAEKSFQKLWQALILSKTVPNARVARLILEDLVEANKDFWPELDQSPTRIS* " /label="malA CDS" gene 814247..815596 /gene="malA" /locus_tag="BSU_08180" /old_locus_tag="BSU08180" /label="malA gene" misc_feature 815625..815644 /Source="Nicolas_upshift_promotors" /id="U625" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=3083 /SigmaFactorBS="cttgatcaaagcccaacccgcatatcataaatgaaattcccc cattttcgaatctgtaATTGTATATAATAGAAAGAAaatggggggatctgatatgcag c" /listShort="malR, malP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 815627 /Source="Nicolas_upshifts" /id="U625" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=3083 /SigmaFactorBS="cttgatcaaagcccaacccgcatatcataaatgaaattcccc cattttcgaatctgtaATTGTATATAATAGAAAGAAaatggggggatctgatatgcag c" /listShort="malR, malP" /GFF_Attribute="listLong" /label="upshifts" CDS 815661..816425 /gene="malR" /locus_tag="BSU_08190" /old_locus_tag="BSU08190" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11489864, 16707683, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489864, 16707683, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the Mal operon" /protein_id="NP_388700.1" /db_xref="EnsemblGenomes-Gn:BSU08190" /db_xref="EnsemblGenomes-Tr:CAB12648" /db_xref="GOA:P54717" /db_xref="InterPro:IPR000281" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR035472" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11847" /db_xref="UniProtKB/Swiss-Prot:P54717" /translation="MQLEELINQHYSKLNDNDFHILKYILNHKHTCYHLGIDALAKAC SVSRSSILRLAQKLGFSGYSEFRVFLKWEDQPEEGESMSFEKLLDDIEANLKFLRTKD MTDMCQLIDAADRIFVYGSGNAQKICARDLQRMFIPRHRYLILIEDTNEFNLMRDDFK VNDLFIIISLSGETPELIPQARMLSAKGIPFISITNLKNNVLAQLTPHNLYATSKPVT LSDRTEIVAFAPFFLVGEALFRAYVDYKEAEKNDNE*" /label="malR CDS" gene 815661..816425 /gene="malR" /locus_tag="BSU_08190" /old_locus_tag="BSU08190" /label="malR gene" promotor_-10 complement(815805..815819) /Source="Nicolas_upshift_promotors" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(815835..815841) /Source="Nicolas_upshift_promotors" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(815835) /Source="Nicolas_upshifts" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 816440..818023 /gene="malP" /locus_tag="BSU_08200" /old_locus_tag="BSU08200" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) maltose-specificenzyme IICB component" /protein_id="NP_388701.1" /db_xref="EnsemblGenomes-Gn:BSU08200" /db_xref="EnsemblGenomes-Tr:CAB12649" /db_xref="GOA:P54715" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR010975" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11848" /db_xref="UniProtKB/Swiss-Prot:P54715" /translation="MMQKIQRFGSAMFVPVLLFAFAGIIVGISTLFKNKTLMGPLADP DGFWYQCWYIIEQGGWTVFNQMPLLFAIGIPVALAKKAQARACLEALTVYLTFNYFVS AILTVWGGAFGVDMNQEVGGTSGLTMIAGIKTLDTNIIGAIFISSIVVFLHNRYFDKK LPDFLGIFQGSTYIVMISFFIMIPIALAVSYIWPMVQSGIGSLQSFLVASGAVGVWIY TFLERILIPTGLHHFIYTPFIYGPAVAEGGIVTYWAQHLGEYSQSAKPLKELFPQGGF ALHGNSKIFGIPGIALAFYVTAKKEKKKLVAGLLIPVTLTAIVAGITEPIEFTFLFIS PFLFAVHAVLAATMSTVMYMAGVVGNMGGGLIEAVTLNWIPLFGSHGMTYVYQILIGL SFTAIYFFVFRFLILKFNIATPGREKDEQQETKLYSKKEYRERKNKDETASAAETADD TAFLYIEALGGKDNITEVTNCATRLRVSVKDETKVEPDSVFRALGAHGVVRNGKAFQV IIGLSVPQMRERVEKILNQ*" /label="malP CDS" gene 816440..818023 /gene="malP" /locus_tag="BSU_08200" /old_locus_tag="BSU08200" /label="malP gene" downshifts 818003 /Source="Nicolas_upshifts" /id="D409" /incds=0 /nref=23 /ntot=46 /MaxReadThrough="3.26652" /MaxDrop="4.69656" /score="8.65399085" /energy="-10.9" /TU="U624" /idTUdmin="U625" /TUdmin=836 /isTUend="FALSE" /label="downshifts" promotor_-35 818052..818059 /Source="Nicolas_upshift_promotors" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 818074..818093 /Source="Nicolas_upshift_promotors" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 818082 /Source="Nicolas_upshifts" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" /label="upshifts" CDS 818129..819850 /gene="yfiB" /locus_tag="BSU_08210" /old_locus_tag="BSU08210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16707683; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative xenobiotic ABC transporter subunit (ATP-binding protein)" /protein_id="NP_388702.1" /db_xref="EnsemblGenomes-Gn:BSU08210" /db_xref="EnsemblGenomes-Tr:CAB12650" /db_xref="GOA:P54718" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11849" /db_xref="UniProtKB/Swiss-Prot:P54718" /translation="MQKALSFLKPYSLLAGIALILMLTELAVELMQPLLIAKIIDDGI LKQDLRHVWIWGTVMIGLTVLSFAAGMLNSFYAAHVSQSFSYDTRKGLFQKIQSFSYS TFGQFSSSSYITRLTNDVTQVQNMIFMSLRFMLRAPLMIAGGIVLSLAVNVKLGFFLL VTIPILILFLLWVLRKGGALFRSVQKRLDQVNTIMQENLIAIKLIKALLRGSHEVKRF IKANTRLMEKTVSAFQLVEFTMPVLMLLMNLCILLILWAGSYSITSGSTQVGDVVAII NYATRITGALSMFPFLIMIFTRAKASGDRIGEVLETEGDEREEGTISDRLSGRIEFQH VSFRYPEMDREALRNVSFSAKPRETIAILGATGSGKSTLFQLIPRLYQPDSGRIYIDE KPVQDIPAEGLRRQIGYVPQEVLLFSGTIKENIAWGKENASLDEIMDAAKLAQIHETI LKLPNGYDTVLGQRGVNLSGGQKQRISIARALIRKPAILLLDDSTSALDLQTEAKLLE AISTYHCTTLIITQKITTAMKADQILLLEDGELIEKGTHSELLSESQLYKRIYESQFG REGSESC*" /label="yfiB CDS" gene 818129..819850 /gene="yfiB" /locus_tag="BSU_08210" /old_locus_tag="BSU08210" /label="yfiB gene" CDS 819844..821658 /gene="yfiC" /locus_tag="BSU_08220" /old_locus_tag="BSU08220" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388703.1" /db_xref="EnsemblGenomes-Gn:BSU08220" /db_xref="EnsemblGenomes-Tr:CAB12651" /db_xref="GOA:P54719" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11850" /db_xref="UniProtKB/Swiss-Prot:P54719" /translation="MLKDIRKPFQYPKLPIDKKEGAKKRAKAKDTKGTLRRIWSYLAE RKGLLILVMLMVVISAIFGLLGPFVIGKAIDHFIVGKTVSGLIPVLLLLLAIYIIQSL SLWFQNYWMITISQGTVFRMRSELFTHLHELPIPFFDKQRHGELMSRVTNDIENVSST LNTSVIQILSSVITFVGTIAVMLYMSPLLTLITLTIIPVMAASLKWITNRTGKLFKEQ QKNLGDLNGYIEESVSGAKVIKAYSREKQITAEFLEKNAALKTSGFWAQTISGFIPKV MNSLNNLSFTMIAAIGGLFALKGWISIGSIVVFAEYSRQFTRPLNDLANQFNTMLSAI AGAERVFDVLDEKEEREDEKNAVHQPIQTGSIEFRDVSFGYDKGQQTLKHLQFTVPAG QSIAFVGPTGAGKTTVTNLLARFYEPNDGKILIDGTDIKTLTRASLRKNMGFVLQDSF LFQGTIRENIRYGRLDASDQEVEAAAKTANAHSFIERLPKGYDTVLTQNGSGISQGQK QLISIARAVLADPVLLILDEATSNIDTVTEVNIQEALARLMEGRTSVIIAHRLNTIQR ADQIVVLKNGEMIEKGSHDELIRQKGFYSDLYESQFEK*" /label="yfiC CDS" gene 819844..821658 /gene="yfiC" /locus_tag="BSU_08220" /old_locus_tag="BSU08220" /label="yfiC gene" downshifts 821633 /Source="Nicolas_upshifts" /id="D410" /incds=0 /nref=103 /ntot=190 /MaxReadThrough="2.4559" /MaxDrop="5.61906" /score="24.4395842" /energy="-11" /TU="NA" /idTUdmin="U627" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 821740..821747 /Source="Nicolas_upshift_promotors" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 821761..821780 /Source="Nicolas_upshift_promotors" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 821765 /Source="Nicolas_upshifts" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" /label="upshifts" CDS 821813..822217 /gene="catD" /locus_tag="BSU_08230" /old_locus_tag="BSU08230" /EC_number="1.13.11.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15849754, 16872404, 16850406, 17407181, 20639328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16872404, 16850406, 17407181, 20639328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catechol-2,3-dioxygenase membrane subunit" /protein_id="NP_388704.1" /db_xref="EnsemblGenomes-Gn:BSU08230" /db_xref="EnsemblGenomes-Tr:CAB12652" /db_xref="GOA:P54720" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG11851" /db_xref="UniProtKB/Swiss-Prot:P54720" /translation="MNKSFEIGTLLLRVITGIIFFVHGLSKFQGMEGTIQFFGSIGLP SFMAYVIAAIELIGGVLVFFGLATRIVGVLFALTLIGAIITVKLKAPFMGNAEFDYLL LLTSIHLALTGSRFLALDPFVFKGKKNGNVSA*" /label="catD CDS" gene 821813..822217 /gene="catD" /locus_tag="BSU_08230" /old_locus_tag="BSU08230" /label="catD gene" CDS 822235..823092 /gene="catE" /locus_tag="BSU_08240" /old_locus_tag="BSU08240" /EC_number="1.13.11.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17407181, 16872404" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17407181, 16872404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catechol-2,3-dioxygenase subunit" /protein_id="NP_388705.2" /db_xref="EnsemblGenomes-Gn:BSU08240" /db_xref="EnsemblGenomes-Tr:CAB12653" /db_xref="GOA:P54721" /db_xref="InterPro:IPR000486" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11852" /db_xref="UniProtKB/Swiss-Prot:P54721" /translation="MTSIHEDTHIGYAKLTIRSLERSLQFYCNVIGFQVLKKTDRQAE LTADGKRVLLILEENPSAVVLPERSVTGLYHFAILLPDRKELGIALARLIEHGIAIGH GDHAVSEALYLSDPDGNGIEMYADRPRSTWQRDREGNYVMTTTAVDIEGLLEEAGDER KTSLPNDTIIGHIHLHVSDLKEAKAFYTDVLGFDIVGNYAGMSALFVSAGGYHHHIGL NIWAGRNAPPKPTNASGLDYYTVVLPHQEELDLVANRVKHAGYSIEETENSFRVKDPV SGAYITFVI*" /label="catE CDS" gene 822235..823092 /gene="catE" /locus_tag="BSU_08240" /old_locus_tag="BSU08240" /label="catE gene" downshifts 823079 /Source="Nicolas_upshifts" /id="D411" /incds=0 /nref=4 /ntot=21 /MaxReadThrough="0.66359" /MaxDrop="3.74886" /score="50.8573531" /energy="-19.7" /TU="NA" /idTUdmin="U628" /TUdmin=16 /isTUend="TRUE" /label="downshifts" CDS 823186..824130 /gene="yfiF" /locus_tag="BSU_08250" /old_locus_tag="BSU08250" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family; cupin family)" /protein_id="NP_388706.1" /db_xref="EnsemblGenomes-Gn:BSU08250" /db_xref="EnsemblGenomes-Tr:CAB12654" /db_xref="GOA:P54722" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG11853" /db_xref="UniProtKB/Swiss-Prot:P54722" /translation="MELNHLVTGKIALNQYVHRLEQKDVSFYVHYWGAMTNHYNTLLH KHSFYEICYVVRGEGYYLEGDRTYPLREQTIFLSKPEHLHQIKSETGLFLFYVAFELS EDQSSAEWIKVMEEVKQSPFITMQLKDGEPPGLLWKTLMLQAAQPVNAFDKEILSHLS HALILSLIQTFLPYAQRPKQKQPIHTSSALLTEVKLHIKDNLSQPLKLTDVASHFHIS GRHLSRLFAAELGVSYSEFVQNEKINKAAELLKSTNLSIKEIAEEIGFSVHYFTRVFS AKIGSSPGLFRSLYKDSKMTAFQINKPFQKIEQAKPHE*" /label="yfiF CDS" gene 823186..824130 /gene="yfiF" /locus_tag="BSU_08250" /old_locus_tag="BSU08250" /label="yfiF gene" downshifts complement(823997) /Source="Nicolas_upshifts" /id="D412" /incds=1 /nref=1 /ntot=2 /MaxReadThrough="-0.20031" /MaxDrop="3.51831" /score="-4.19869956" /energy="-9.5" /TU="NA" /idTUdmin="U632" /TUdmin=9372 /isTUend="FALSE" /label="downshifts" promotor_no_box complement(824045..824145) /Source="Nicolas_upshift_promotors" /id="U629" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.533466533466533" /psig="0.034965034965035" /xcortree=1481 /SigmaFactorBS="tcatttcaggacatcttattcgtgcggcttggcctgttcgat tttttgaaaaggtttattgatttgaaatgcggtcatttttgagtctttataaagggag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(824085) /Source="Nicolas_upshifts" /id="U629" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.533466533466533" /psig="0.034965034965035" /xcortree=1481 /SigmaFactorBS="tcatttcaggacatcttattcgtgcggcttggcctgttcgat tttttgaaaaggtttattgatttgaaatgcggtcatttttgagtctttataaagggag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 824305..825753 /gene="yfiG" /locus_tag="BSU_08260" /old_locus_tag="BSU08260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar/proton transporter" /protein_id="NP_388707.1" /db_xref="EnsemblGenomes-Gn:BSU08260" /db_xref="EnsemblGenomes-Tr:CAB12655" /db_xref="GOA:P54723" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11854" /db_xref="UniProtKB/Swiss-Prot:P54723" /translation="MSTKKKEAVIGKESLAHKGLLRTITLVSTFGGLLFGYDTGVING ALPFMATAGQLNLTPVTEGLVASSLLLGAAFGAMFGGRLSDRHGRRKTILYLALLFIA ATLGCTFSPNASVMIAFRFLLGLAVGCASVTVPTFLAEISPAERRGRIVTQNELMIVI GQLLAYTFNAIIGSTMGESANVWRYMLVIATLPAVVLWFGMLIVPESPRWLAAKGRMG DALRVLRQIREDSQAQQEIKEIKHAIEGTAKKAGFHDFQEPWIRRILFIGIGIAIVQQ ITGVNSIMYYGTEILREAGFQTEAALIGNIANGVISVIAVIFGIWLLGKVRRRPMLII GQIGTMTALLLIGILSIVLEGTPALPYVVLSLTILFLAFQQTAISTVTWLMLSEIFPM HVRGLGMGISTFCLWTANFLIGFTFPILLNHIGMSATFFIFVAMNILAILFVKKYVPE TKGRSLEQLEHSFRQYGRRADQEIQNQTTHLS*" /label="yfiG CDS" gene 824305..825753 /gene="yfiG" /locus_tag="BSU_08260" /old_locus_tag="BSU08260" /label="yfiG gene" CDS 825780..826721 /gene="yfiH" /locus_tag="BSU_08270" /old_locus_tag="BSU08270" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar-phosphate epimerase/isomerase" /protein_id="NP_388708.1" /db_xref="EnsemblGenomes-Gn:BSU08270" /db_xref="EnsemblGenomes-Tr:CAB12656" /db_xref="InterPro:IPR011418" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11855" /db_xref="UniProtKB/Swiss-Prot:P54724" /translation="MKLSYVTDSLGHLPFEDMLNFAAKLGIDTLEMTTGGWSPAPHLN LDELLQSSEKRKEFSQALEKRNMTLCALNCSGNPLDPGELGKSHRDITDKTMELAGLL GVKKVIMMSGLPAGGPDDKVPNWITYTVSWPPVLKDILNYQWEDVAIPYWKKLVKKAE ACGVGKIALENFSSQLVYNPETLFRLRNAVGPMVGLNLDPSHLLWMGADPIIAARELG SAIHHVHGKDVRIERYLSAVNGLLETKEVTDPANRAWNYVAVGCGQDLQWWKEFFSVV KMMGYEGEVSLEMEDLTMSPEAGIRTSVEALKQTISQ*" /label="yfiH CDS" gene 825780..826721 /gene="yfiH" /locus_tag="BSU_08270" /old_locus_tag="BSU08270" /label="yfiH gene" CDS 826731..827912 /gene="yfiI" /locus_tag="BSU_08280" /old_locus_tag="BSU08280" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26438878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388709.1" /db_xref="EnsemblGenomes-Gn:BSU08280" /db_xref="EnsemblGenomes-Tr:CAB12657" /db_xref="GOA:P94437" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12214" /db_xref="UniProtKB/Swiss-Prot:P94437" /translation="MMLNGERIISKPLRWAMVGGGRLSQVGYKHRIGALRDNTAFQLT AGAFDIDAERGKDFGVNLGVDAERCYPNYQTMFAEEAKRQDGIEVVSIATPNGTHYEI CKAALEAGVHVICEKPLFFTSAEGQEIKALAEKKGKIVGVTYGFSGNQMLLQMRAMIE QGMIGDIRVVDLQYTHGFCATDEGEKISAAQKWRVDPAIAGPSFVLGDLSTHTYYMSQ LIMPKMKIKELLCDRQSFVGSRAPLEDNAHVLMHYENGAVGTMWTSSINAGCMDGHRI RIVGSKASIEWWDSKPNELTYEVQGEPGQTLVRGMPYLDDVCNADERLGALHSEGLSE AWANIYLKFAIAIDAKNREDEEILNNLVYPDIDAGIEGIRWIENCVRSANQGSVWVEF K*" /label="yfiI CDS" gene 826731..827912 /gene="yfiI" /locus_tag="BSU_08280" /old_locus_tag="BSU08280" /label="yfiI gene" downshifts 827902 /Source="Nicolas_upshifts" /id="D413" /incds=0 /nref=40 /ntot=113 /MaxReadThrough="0.88387" /MaxDrop="5.80704" /score="14.819468" /energy="-13" /TU="NA" /idTUdmin="U630" /TUdmin="-2003" /isTUend="FALSE" /label="downshifts" promotor_-35 827972..827978 /Source="Nicolas_upshift_promotors" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 827993..828012 /Source="Nicolas_upshift_promotors" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 828011 /Source="Nicolas_upshifts" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" /label="upshifts" CDS 828036..829238 /gene="linJ" /locus_tag="BSU_08290" /old_locus_tag="BSU08290" /function="16.12: Sense" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11717295, 12618459, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12618459, 28461449; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LinK] (linearmycin resistance, biofilm formation)" /protein_id="NP_388710.1" /db_xref="EnsemblGenomes-Gn:BSU08290" /db_xref="EnsemblGenomes-Tr:CAB12658" /db_xref="GOA:P94438" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12215" /db_xref="UniProtKB/Swiss-Prot:P94438" /translation="MKALFFTRMFTLMVSCLMYLSIVKEDNWFGYVFIAAGAAMYAAN HVLLTKETNAIWFCLIDIAIGFSFGFIFPGTGLFIIMLCPVAVAFFLRGFPKRTAWSV LCLSSILFLTVLIRTYAMFGNEFVIDHLTSMTFVVFCGVVGKLIRKLLDAQDTAKQQF QELTESHLALSAAHQELHLYAKQVEELTAIYERNRMAREIHDTVGHKMTALLVQLQLL REWQKRDSQKADETVGVCETLAREALDDVRLSVRTLQTENDPSLIESLKQLTEDFCKN AGVTTEFAVSGDPAIIPLSLHPTLIRTVQEALTNAKRHGGAAACSIQLACTTDSISLV IKDDGKGNPEAALGFGLLNMKKRAAEHGGMIRFESERDQGFTVNAEFSLANKKWSFGP VQQKESLS*" /label="linJ CDS" gene 828036..829238 /gene="linJ" /locus_tag="BSU_08290" /old_locus_tag="BSU08290" /label="linJ gene" CDS 829235..829897 /gene="linK" /locus_tag="BSU_08300" /old_locus_tag="BSU08300" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12618459, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12618459, 28461449; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [LinJ] (linearmycin resistance, biofilm formation)" /protein_id="NP_388711.1" /db_xref="EnsemblGenomes-Gn:BSU08300" /db_xref="EnsemblGenomes-Tr:CAB12659" /db_xref="GOA:P94439" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12216" /db_xref="UniProtKB/Swiss-Prot:P94439" /translation="MIKIIITDDQDIVREGLASLLQLREELDVIATARNGQEAFEKAK ELEPDIVLMDIRMPVSNGVEGTKLITSSLPSVKVLMLTTFKDSALIAEALEEGASGYL LKDMSADTIVKAVMTVHSGGMVLPPELTAQMLNEWKREKQLKGINEIEKPNELLDLTE REIEVLAELGYGLNNKEIAEKLYITEGTVKNHVSNIISKLAVRDRTQAAIYSVRYGVS VF*" /label="linK CDS" gene 829235..829897 /gene="linK" /locus_tag="BSU_08300" /old_locus_tag="BSU08300" /label="linK gene" downshifts 829905 /Source="Nicolas_upshifts" /id="D414" /incds=0 /nref=114 /ntot=229 /MaxReadThrough="-0.0105699999999995" /MaxDrop="4.23231" /score="20.4785449" /energy="-7.6" /TU="NA" /idTUdmin="U630" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 830041..830976 /gene="bifL" /locus_tag="BSU_08310" /old_locus_tag="BSU08310" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) biofilm formation" /protein_id="NP_388712.2" /db_xref="EnsemblGenomes-Gn:BSU08310" /db_xref="EnsemblGenomes-Tr:CAB12660" /db_xref="GOA:P94440" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12217" /db_xref="UniProtKB/Swiss-Prot:P94440" /translation="MLQAENIKKAYGKKTIVKGISFSLKKGESFGLLGPNGAGKSTTI SMISGLVPHDSGNITVGGYVIGKETAKAKQKIGIVPQEIALYPTLTAHENLMFWGKMY GLTHGEAKKRAAEVLEYVGLTERAKDKIETFSGGMKRRINIGAALMHKPELLIMDEPT VGIDPQSRNHILETVKQLNETGMTVIYTSHYMEEVEFLCDRIGIIDQGEMIAIGTKTD LCSRLGGDTIIQLTVSGINEAFLVAIRSLAHVNDVTVHELELKIDISAAHHEKVVTSL LAEATAHHINLLSLQVQEPNLERLFLNLTGRTLRD*" /label="bifL CDS" gene 830041..830976 /gene="bifL" /locus_tag="BSU_08310" /old_locus_tag="BSU08310" /label="bifL gene" CDS 830989..832179 /gene="bifM" /locus_tag="BSU_08320" /old_locus_tag="BSU08320" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) biofilm formation" /protein_id="NP_388713.1" /db_xref="EnsemblGenomes-Gn:BSU08320" /db_xref="EnsemblGenomes-Tr:CAB12661" /db_xref="GOA:P94441" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12218" /db_xref="UniProtKB/Swiss-Prot:P94441" /translation="MKKSIWIAWKDVKIRITDRKGFMMLILMPLILTCILGAALGSVV DGGSRIDDIKVGYIQSDQSDTANMFTKDVLKKMKSIKVTKVGSKDKMKKLIDEKKIDV GIVIPNHWEAGKTSAVVNAAPDQTLKSSIIETAASSFIEQYKAVKEAASGSMDYISKT EAVKQGKLDPAQFAEKLAKTLEKETGDKLTIAEKSVGSKAVTSFQYYSAAMLCMFMLF HITVGAKSFLQEKDTETLARMLMTPAQKSVILFGKWLGTYLFAIIQFFIFLIVTINVF GVDWGGNLLLVSVLGLSYAAAVSGISMLLASCISDMKTADAIGGFGIQLLAVLGGSML PLYQFPDVLQSVSKAVPNRWALDGFLSLMEGGGWADLQKPVLLFAAIGFCSLVIGIRR LHTR*" /label="bifM CDS" gene 830989..832179 /gene="bifM" /locus_tag="BSU_08320" /old_locus_tag="BSU08320" /label="bifM gene" CDS 832193..833350 /gene="bifN" /locus_tag="BSU_08330" /old_locus_tag="BSU08330" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) biofilm formation" /protein_id="NP_388714.1" /db_xref="EnsemblGenomes-Gn:BSU08330" /db_xref="EnsemblGenomes-Tr:CAB12662" /db_xref="GOA:P94442" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12219" /db_xref="UniProtKB/Swiss-Prot:P94442" /translation="MKKILAICGIELSLIFKKPQNYLIMFAAPLLLTFVFGSMLSGND DKVRLAIVDQDDTILSQHYIRQLKAHDDMYVFENMSESKASEKLKQKKIAGIIVISRS FQTQLEKGKHPELIFRHGPELSEAPMVKQYAESALATLNIQVTAAKTASQTAGENWKA AYKTVFAKKHEDIVPAVTRQTLSDKKEGAEASDTASRAAGFSILFVMLTMMGAAGTIL EARKNGVWSRLLTASVSRAEIGAGYVLSFFVIGWIQFGILLLSTHWLFGINWGNPAAV IVLVSLFLLTVVGIGLMIAANVRTPEQQLAFGNLFVIATCMVSGMYWPIDIEPKFMQS IAEFLPQKWAMSGLTEIIANGARVTDILGICGILLAFAAITFAAGLKALRA*" /label="bifN CDS" gene 832193..833350 /gene="bifN" /locus_tag="BSU_08330" /old_locus_tag="BSU08330" /label="bifN gene" promotor_-35 832304..832309 /Source="Nicolas_upshift_promotors" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 832324..832342 /Source="Nicolas_upshift_promotors" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 832325 /Source="Nicolas_upshifts" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(833348..833422) /Source="Nicolas_S_feature" /locus_tag="new_909123_909197_c" /HighExp="LoTm, Sw, C90, HiOs, BC, MG 45, UNK1, Fru, S1, BI" /AntisenseName="yfiN" /AntisenseCor="-6.3486715356968801E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S284" downshifts complement(833391) /Source="Nicolas_upshifts" /id="D415" /incds=0 /nref=90 /ntot=257 /MaxReadThrough="1.41433" /MaxDrop="6.01369" /score="13.7314837" /energy="-11.5" /TU="U632" /idTUdmin="U632" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(833423..833971) /gene="padR" /locus_tag="BSU_08340" /old_locus_tag="BSU08340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11073918, 17295427, 18326577, 21685295, 23189126, 27716049, 28027933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11073918, 17295427, 18326577, 21685295, 23189126, 27716049, 28027933; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of phenolic acid decarboxylase" /protein_id="NP_388715.1" /db_xref="EnsemblGenomes-Gn:BSU08340" /db_xref="EnsemblGenomes-Tr:CAB12663" /db_xref="GOA:P94443" /db_xref="InterPro:IPR005149" /db_xref="InterPro:IPR018309" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12220" /db_xref="UniProtKB/Swiss-Prot:P94443" /translation="MRVLKYAILGLLRKGELSGYDITSYFKEELGQFWSAKHSQIYPE LKKLTDEGFITFRTTIQGTKLEKKMYTLTDSGKQELHDWLIRHQPIPETVKDEFMLKA YFISCLSRQEASDLFKDQLQKRQAKLSDLQGSYEKLMASAEPMSFSSPDFGHYLVLTK ALEREKNYVSWLESILAMIDKD*" /label="padR CDS" gene complement(833423..833971) /gene="padR" /locus_tag="BSU_08340" /old_locus_tag="BSU08340" /label="padR gene" S_feature complement(833972..834051) /Source="Nicolas_S_feature" /locus_tag="new_909747_909826_c" /HighExp="LoTm, Cold, G180, GM-0.2, Oxctl, T5.0H, GM 25, T3.30H, MG 60, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S285" promotor_-10 complement(834040..834059) /Source="Nicolas_upshift_promotors" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(834051) /Source="Nicolas_upshifts" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(834073..834078) /Source="Nicolas_upshift_promotors" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 834174..834177 /Source="Nicolas_upshift_promotors" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 834193..834212 /Source="Nicolas_upshift_promotors" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 834200 /Source="Nicolas_upshifts" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" /label="upshifts" CDS 834244..834876 /gene="estB" /locus_tag="BSU_08350" /old_locus_tag="BSU08350" /EC_number="3.1.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11029590, 10913700, 21574267" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11029590, 10913700, 21574267; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted esterase / acylglycerol lipase" /protein_id="NP_388716.1" /db_xref="EnsemblGenomes-Gn:BSU08350" /db_xref="EnsemblGenomes-Tr:CAB12664" /db_xref="GOA:Q79F14" /db_xref="InterPro:IPR002918" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11951" /db_xref="UniProtKB/Swiss-Prot:Q79F14" /translation="MKKVLMAFIICLSLILSVLAAPPSGAKAESVHNPVVLVHGISGA SYNFFAIKNYLISQGWQSNKLYAIDFYDKTGNNLNNGPQLASYVDRVLKETGAKKVDI VAHSMGGANTLYYIKYLGGGNKIQNVVTLGGANGLVSSTALPGTDPNQKILYTSIYSL NDQIVINSLSRLQGARNIQLYGIGHIGLLSNSQVNGYIKEGLNGGGLNTN*" /label="estB CDS" gene 834244..834876 /gene="estB" /locus_tag="BSU_08350" /old_locus_tag="BSU08350" /label="estB gene" downshifts 834855 /Source="Nicolas_upshifts" /id="D416" /incds=0 /nref=7 /ntot=100 /MaxReadThrough="0.87881" /MaxDrop="2.6151" /score="0.223019698" /energy="-8.5" /TU="NA" /idTUdmin="U633" /TUdmin=88 /isTUend="FALSE" /label="downshifts" promotor_-35 834991..834996 /Source="Nicolas_upshift_promotors" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 835010..835029 /Source="Nicolas_upshift_promotors" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 835020 /Source="Nicolas_upshifts" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" /label="upshifts" CDS 835065..836153 /gene="icaC" /locus_tag="BSU_08360" /old_locus_tag="BSU08360" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 24776724, 25935415, 27303652; Product type t : transporter" /codon_start=1 /transl_table=11 /product="acetyl-glucosamine metabolite exporter componentinvolved in biofilm formation" /protein_id="NP_388717.1" /db_xref="EnsemblGenomes-Gn:BSU08360" /db_xref="EnsemblGenomes-Tr:CAB12665" /db_xref="GOA:O31559" /db_xref="InterPro:IPR002656" /db_xref="SubtiList:BG12893" /db_xref="UniProtKB/Swiss-Prot:O31559" /translation="MQIKEIFMIRCISCLSVVLLHIISMVLMLQAEALADISHTVDSF RTLLMFSTPAFIFISEFLLARSYPDGVPDGFLKKRGKVIFVPFLFIAAIDALLMTSAM GGEVTFLAFVQKYLANVFLGNFIGYFILVIFQFYMLHMMFHEYLKKASPKWVLSISFV VTAAYLGYFSAASPAPASEEGGAFPFFWVPFAGWLFYFCLAYYCGKEYKRFLALLNQY RWVVYGAAIASGALVVTVSYVGEIGMISSKRPDIMLYSTSMIFLCFHLFSKMKHVPKI MMFISNYSFSIYLLHAYFMIIGYVLLLNMPEIPAVPAVLLLFAVCTAGPIMTSWALNK FKYGYLFVGKIYQPKQKKVTVEVRDHAG*" /label="icaC CDS" gene 835065..836153 /gene="icaC" /locus_tag="BSU_08360" /old_locus_tag="BSU08360" /label="icaC gene" S_feature complement(835555..835943) /Source="Nicolas_S_feature" /locus_tag="new_911330_911718_c" /HighExp="S6, S8, S7, S5, LBGstat, H2O2, Mt0, Cold, G180, LPhT" /AntisenseName="yfiQ" /AntisenseCor="0.36913176163336098" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.976" /TUlongSig="NA" /TUlongPSig="NA" /label="S286" upshifts complement(835943) /Source="Nicolas_upshifts" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(835945..835964) /Source="Nicolas_upshift_promotors" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(835977..835985) /Source="Nicolas_upshift_promotors" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(836189..836806) /gene="yfiR" /locus_tag="BSU_08370" /old_locus_tag="BSU08370" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16862575" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16862575; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388718.1" /db_xref="EnsemblGenomes-Gn:BSU08370" /db_xref="EnsemblGenomes-Tr:CAB12666" /db_xref="GOA:O31560" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:1RKT" /db_xref="SubtiList:BG12894" /db_xref="UniProtKB/Swiss-Prot:O31560" /translation="MSPKVTKEHKDKRQAEILEAAKTVFKRKGFELTTMKDVVEESGF SRGGVYLYFSSTEEMFRRIIETGLDEGLRKLDKSAEHQSVWASISSYLDELTEGLRDV ADTLAPVQFEYLVTAWRNEERRQYLEKRYDLFVERFSRLLQKGIDQGEFQPVQPLATI AKFFLNMNDGIIQNALYFDEEKADVSGLAESAKLYLKTVLQADEK*" /label="yfiR CDS" gene complement(836189..836806) /gene="yfiR" /locus_tag="BSU_08370" /old_locus_tag="BSU08370" /label="yfiR gene" downshifts complement(836207) /Source="Nicolas_upshifts" /id="D417" /incds=0 /nref=29 /ntot=209 /MaxReadThrough="2.44114" /MaxDrop="4.07715" /score="22.1532141" /energy="-17.1" /TU="NA" /idTUdmin="U636" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(836772..838025) /gene="yfiS" /locus_tag="BSU_08380" /old_locus_tag="BSU08380" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9811639, 15849754, 16850406, 16862575; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388719.1" /db_xref="EnsemblGenomes-Gn:BSU08380" /db_xref="EnsemblGenomes-Tr:CAB12667" /db_xref="GOA:O31561" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12895" /db_xref="UniProtKB/Swiss-Prot:O31561" /translation="MEKPLFRNQKGLMTLLASQTISSLGDWLHILAVLTLAAFQLHAS PLDMSLLMMSFALPVIVLGPVSGLLADRFDRKTIMFLSEIGRALTVISCVYVSELWQL YVLLSVQSCFSSLFLPAKNGKLKELAPEAHIQQAVSVSSIIDNSSKIFGPALGGTLIA AFSIHSVFYINAGAFFLSAVILFFLPRDAFLQKANTPQEKTAALTSIKEGLQFLKRMP LLLTGLLTACVVLFVLQIGDSQAIILIRSFSGAPPELAGWCMAVSGAGMLLTAAITGR RRITSYLLYFSAGTLLLGLATGGAPFLSGMGIAGITLFIFAFFIMGAAFGLVHIPFQI LVQTTVPVDYSGRVFGAIQSATTLASILGMAGGGVLAEWIGVSLAFLVCGCLLIMIGL ITLIGKKIAESRRYLVTKSNKGAQG*" /label="yfiS CDS" gene complement(836772..838025) /gene="yfiS" /locus_tag="BSU_08380" /old_locus_tag="BSU08380" /label="yfiS gene" promotor_-10 complement(836833..836852) /Source="Nicolas_upshift_promotors" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(836845) /Source="Nicolas_upshifts" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(836866..836873) /Source="Nicolas_upshift_promotors" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(838059..838078) /Source="Nicolas_upshift_promotors" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(838077) /Source="Nicolas_upshifts" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(838093..838100) /Source="Nicolas_upshift_promotors" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 838104..838123 /Source="Nicolas_upshift_promotors" /id="U638" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.98901098901099" /xcortree=3204 /SigmaFactorBS="atgacactagtgtcgtttttaattgtatgggaaaaagacaca atatacaatctttTTCTTGTAAAATAAAGGAGAagattgaatagaagggagaacattc a" /listShort="yfiT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 838109 /Source="Nicolas_upshifts" /id="U638" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.98901098901099" /xcortree=3204 /SigmaFactorBS="atgacactagtgtcgtttttaattgtatgggaaaaagacaca atatacaatctttTTCTTGTAAAATAAAGGAGAagattgaatagaagggagaacattc a" /listShort="yfiT" /GFF_Attribute="listLong" /label="upshifts" CDS 838149..838685 /gene="bstA" /locus_tag="BSU_08390" /old_locus_tag="BSU08390" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15581359, 22059487, 24821014, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15581359, 22059487, 24821014, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillithiol S-transferase" /protein_id="NP_388720.1" /db_xref="EnsemblGenomes-Gn:BSU08390" /db_xref="EnsemblGenomes-Tr:CAB12668" /db_xref="GOA:O31562" /db_xref="InterPro:IPR023774" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="PDB:1RXQ" /db_xref="SubtiList:BG12896" /db_xref="UniProtKB/Swiss-Prot:O31562" /translation="MTSVNLSYPIGEYKPRESISKEQKDKWIQVLEEVPAKLKQAVEV MTDSQLDTPYRDGGWTVRQVVHHLADSHMNSYIRFKLSLTEETPAIRPYDEKAWSELK DSKTADPSGSLALLQELHGRWTALLRTLTDQQFKRGFYHPDTKEIITLENALGLYVWH SHHHIAHITELSRRMGWS*" /label="bstA CDS" gene 838149..838685 /gene="bstA" /locus_tag="BSU_08390" /old_locus_tag="BSU08390" /label="bstA gene" CDS complement(838682..840238) /gene="yfiU" /locus_tag="BSU_08400" /old_locus_tag="BSU08400" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388721.1" /db_xref="EnsemblGenomes-Gn:BSU08400" /db_xref="EnsemblGenomes-Tr:CAB12669" /db_xref="GOA:O31563" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12897" /db_xref="UniProtKB/Swiss-Prot:O31563" /translation="MSEALTEQKSQKWAISLFTIGVFMAALDNGIISAALTTINESFS VSPSWGSWGITLYTLGLSVSVPIVGKLSDRYGRKKLFLIEVCLFGLGSLLVALSQSFP LFLISRLIQALGGGGIFIIGSSHILATLPKEKQGKALGLLGAMNGMAAVLGPNIGSFL LDWTGSWHWLFLINLPIAVLLVVFGACFIAETKAPEAKRLDAAGIFLLSLSILAVMYG MTNLDGANLLHSLGNPEVYGCIIFGILCFAALISYEKRVEMRGGDPILAYSLLRNHMF QRTLIIGLLSGGLLAAVIFIPSYVEQYLGVPAAKAGYWMTPLALASGIGAWLGGALTD KKGPVKTVILSGIISCAGFALFPLWVTEKWEFVIASVAAGIGFGFLLGAPLNVLVSEA AKTNKGTALGTLSLVRQIGLTLAPTLYAGFITAGFDQIGDEINSRLSDSGYSEKAMQM IPEIDSSEVSSLQEQIERIPVPEVKTAISDAIHASVASGYDHLYAAAAVVSLLVIAAI SIPAFRRQKR*" /label="yfiU CDS" gene complement(838682..840238) /gene="yfiU" /locus_tag="BSU_08400" /old_locus_tag="BSU08400" /label="yfiU gene" promotor_-10 complement(840260..840278) /Source="Nicolas_upshift_promotors" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(840277) /Source="Nicolas_upshifts" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(840294..840297) /Source="Nicolas_upshift_promotors" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(840349..840831) /gene="yfiV" /locus_tag="BSU_08410" /old_locus_tag="BSU08410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18990441; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_388722.1" /db_xref="EnsemblGenomes-Gn:BSU08410" /db_xref="EnsemblGenomes-Tr:CAB12670" /db_xref="GOA:O31564" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12898" /db_xref="UniProtKB/Swiss-Prot:O31564" /translation="MEYNLHDTTVLNENILSSEEREIWVLYMKVLTSAGLGDVSEWMK LDMSMPQMKVLMLLNNHGTLKVSDIAEKMGASLSNTTGLLDRLEKSGFVKRSHSEEDR RSVVVQLTENAKKIFRGLYEKGHLKLKRSLELLSPEEKQAVYEGLSILSRALENAKKE *" /label="yfiV CDS" gene complement(840349..840831) /gene="yfiV" /locus_tag="BSU_08410" /old_locus_tag="BSU08410" /label="yfiV gene" downshifts complement(840365) /Source="Nicolas_upshifts" /id="D418" /incds=0 /nref=58 /ntot=177 /MaxReadThrough="1.47849" /MaxDrop="4.15907" /score="27.2704527" /energy="-14.2" /TU="NA" /idTUdmin="U640" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(840856..840875) /Source="Nicolas_upshift_promotors" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(840872) /Source="Nicolas_upshifts" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(840890..840896) /Source="Nicolas_upshift_promotors" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 840917..840924 /Source="Nicolas_upshift_promotors" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 840938..840957 /Source="Nicolas_upshift_promotors" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 840946 /Source="Nicolas_upshifts" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="upshifts" CDS 841003..843573 /gene="mprF" /locus_tag="BSU_08425" /old_locus_tag="BSU08425" /EC_number="2.3.2.3" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:2139213, 2490162, 12427923, 14702396, 15849754, 16299297, 16850406, 17042784, 19074395, 21306448, 26261323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2139213, 2490162, 12427923, 14702396, 15849754, 16299297, 16850406, 17042784, 19074395, 21306448, 26261323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylglycerol lysyltransferase involved in tRNA-dependent lysinylation of phospholipids" /protein_id="YP_003097695.1" /db_xref="EnsemblGenomes-Gn:BSU08425" /db_xref="EnsemblGenomes-Tr:CAX52582" /db_xref="GOA:C0H3X7" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR022791" /db_xref="InterPro:IPR024320" /db_xref="UniProtKB/Swiss-Prot:C0H3X7" /translation="MLIKKNALSILKIVFPIAVLLFVIYQSKKELTNLSFKRTLMVIN GLERTDLFMLVLIGLLAVAAMSLYDYVLKYSLRLSITNGKVFRVSWIANSFNNVLGFG GLAGVGLRMMFYKEHTKDHKALVKGIAWLTSSMLLGLSVFSIFVAARVLPVDEVIHEK PWLWAVVIGFALILPLSLAVSKIKDRKAGDEENADKVKNPIFAYIGASVVEWLMAGTV IYFALFAMGIHADIRYVFGVFVIAAIGGMISLVPGGFGSFDLLFLLGMEQLGYHQEAI VTSIVLYRLAYSFIPFILGLFFAAGDLTENTMKRLETNPRIAPAIETTNVLLVVQRAV LVRILQGSLSLIVFVAGLIVLASVSLPIDRLTVIPHIPRPALLLFNGLSLSSALILLI LPIELYKRTKRSYTMAITALVGGFVFSFLKGLNISAIFVLPMIIVLLVLLKKQFVREQ ASYTLGQLIFAVALFTVALFNYNLIAGFIWDRMKKVLRHEYFVHSTSHITHATIMAII IVPLFFLIFTVVYHKRTKPIGEKADPERLAAFLNEKGGNALSHLGFLGDKRFYFSSDG NALLLFGKIARRLVVLGDPSGQRESFPLVLEEFLNEAHQKGFSVLFYQIEREDMALYH DFGYNFFKLGEEAYVDLNTFTLTGKKKAGLRAINNRFEREEYTFHVDHPPFSDAFLEE LKQISDEWLGSKKEKGFSLGFFDPSYLQKAPIAYMKNAEGEIVAFANVMPMYQEGEIS VDLMRYRGDAPNGIMDALFIRMFLWAKEEGCTSFNMGMAPLANVGTAFTSFWSERFAA VIFNNVRYMYSFSGLRAFKEKYKPEWRGKYLAYRKNRSLSVTMFLVTRLIGKSKKDSV *" /label="mprF CDS" gene 841003..843573 /gene="mprF" /locus_tag="BSU_08425" /old_locus_tag="BSU08425" /label="mprF gene" downshifts 843544 /Source="Nicolas_upshifts" /id="D419" /incds=0 /nref=121 /ntot=252 /MaxReadThrough="1.79352" /MaxDrop="5.78159" /score="49.2396824" /energy="-16.1" /TU="NA" /idTUdmin="U641" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(843591..844568) /gene="sxzY" /locus_tag="BSU_08440" /old_locus_tag="BSU08440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12354229, 19254027, 24606332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter binding lipoprotein" /protein_id="NP_388725.1" /db_xref="EnsemblGenomes-Gn:BSU08440" /db_xref="EnsemblGenomes-Tr:CAB12673" /db_xref="GOA:O31567" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG12901" /db_xref="UniProtKB/Swiss-Prot:O31567" /translation="MKKHISMLFVFLMAVMVLSACNSSESSSNSEVSSSKTRTVKHAM GTSDNIPANPKRIVVLTNEGTEALLALGIKPVGAVKSWKGDPWYDYLKDDMKGVKNVG LETEPNVEAIAELKPDLIIGNKVRQEKIYDQLNAIAPTVFAESLAGNWKDNLTLYANA VNKADKGKEVIADFDKRVSDLKNKLGDQTNKTVSVVRFLSGESRIYYTDSFPGIILDQ LGFKRPEKQVELFKKQKDQFTFSTDSKESIPDMDADVLFYFTYKADNAKENEKWANQW TSSSLWKNLKAVKSGNAHEVDDVVWTTAGGIKAANYLLDDIETYFLKTK*" /label="sxzY CDS" gene complement(843591..844568) /gene="sxzY" /locus_tag="BSU_08440" /old_locus_tag="BSU08440" /label="sxzY gene" downshifts complement(843602) /Source="Nicolas_upshifts" /id="D420" /incds=0 /nref=165 /ntot=248 /MaxReadThrough="1.28876" /MaxDrop="7.70135" /score="35.2605181" /energy="-16.1" /TU="NA" /idTUdmin="U643" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-35 844583..844590 /Source="Nicolas_upshift_promotors" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(844595..844614) /Source="Nicolas_upshift_promotors" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 844605..844624 /Source="Nicolas_upshift_promotors" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 844607..844698 /Source="Nicolas_S_feature" /locus_tag="new_920382_920473" /HighExp="dia0, Lbexp, LBGexp, H2O2, G150, GM 10, Oxctl, dia15, Paraq, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S287" upshifts 844607 /Source="Nicolas_upshifts" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(844612) /Source="Nicolas_upshifts" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(844629..844636) /Source="Nicolas_upshift_promotors" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="promotor_-35" CDS 844699..845700 /gene="sxzZ" /locus_tag="BSU_08450" /old_locus_tag="BSU08450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 19254027" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 19254027; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter (permease)" /protein_id="NP_388726.1" /db_xref="EnsemblGenomes-Gn:BSU08450" /db_xref="EnsemblGenomes-Tr:CAB12674" /db_xref="GOA:O31568" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12902" /db_xref="UniProtKB/Swiss-Prot:O31568" /translation="MICKKASSKWIVLVCLIFILLTAVCASVVYGYTGTSWRQVYQAF TSFNGTNEHVIIKDVRLPRALVATVVGASLAAAGALMQALTKNPLASPGIFGINAGAG FFIVAGSFFLHIQSPQALVWSSFLGAAFTAAIVYAAGSLGREGLTPIKLTLAGAAMAA MFSSLTQGLLSVNELELAQVLFWLTGSVQGRSLDLLMTMFPYAAAALVICFFLGQKIN LLVMGEDVAKGLGQKTGLLKFVMALCVVMLAGSAVAIAGPISFIGIIIPHFARFVVGN DYRWVLPFSAVLGAILLVCADIGARYIIMPQEVPVGVMTAIIGMPVFVYIARRGAKL* " /label="sxzZ CDS" gene 844699..845700 /gene="sxzZ" /locus_tag="BSU_08450" /old_locus_tag="BSU08450" /label="sxzZ gene" CDS 845697..846728 /gene="sxzA" /locus_tag="BSU_08460" /old_locus_tag="BSU08460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 19254027" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 19254027; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter (permease)" /protein_id="NP_388727.1" /db_xref="EnsemblGenomes-Gn:BSU08460" /db_xref="EnsemblGenomes-Tr:CAB12675" /db_xref="GOA:O31569" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12876" /db_xref="UniProtKB/Swiss-Prot:O31569" /translation="MKLRFGVTAAEKKAWIVFLVLLGLTAAVLIISAGLGQRFIPPWD VAKTFFGAGSKLDELMIMSFRMPRILTALCAGVCLAAAGAILQGLVRNPLASPDIIGI TGGAAVAVVLLMMFFSDRSSSLTISLSWLPAAAFIGASAVGLIVYLLAYKNGASTFRL VLIGIGFSMSAQAMTTLLMIKGPIYRASQANVYITGSVYGSNWQHVKIAIILSVILLF ICFVALKNMNIQVLGEDIAAGAGSAVQRNRFFLLLLSTALTGCAVSVAGTIGFVGLMA PHIARRLVGSSYGALLPASALIGALLVLTADIVGRTLFAPVEVPAGVFTAAIGAPYFI YLLYKTRNS*" /label="sxzA CDS" gene 845697..846728 /gene="sxzA" /locus_tag="BSU_08460" /old_locus_tag="BSU08460" /label="sxzA gene" downshifts 846709 /Source="Nicolas_upshifts" /id="D421" /incds=0 /nref=24 /ntot=154 /MaxReadThrough="3.26686" /MaxDrop="4.27732" /score="19.6751667" /energy="-12.8" /TU="NA" /idTUdmin="U642" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 846779..846781 /Source="Nicolas_upshift_promotors" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 846797..846816 /Source="Nicolas_upshift_promotors" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 846800 /Source="Nicolas_upshifts" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="upshifts" CDS 846843..847724 /gene="yfhB" /locus_tag="BSU_08470" /old_locus_tag="BSU08470" /EC_number="5.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative isomerase" /protein_id="NP_388728.1" /db_xref="EnsemblGenomes-Gn:BSU08470" /db_xref="EnsemblGenomes-Tr:CAB12676" /db_xref="GOA:O31570" /db_xref="InterPro:IPR003719" /db_xref="SubtiList:BG12877" /db_xref="UniProtKB/Swiss-Prot:O31570" /translation="MKEAEVLKYEAFTSSPGKGNPAGVVLQGDDYTEDEMQIIAERAG YSETSFIRKSESADLELRYFTPGHEMNLCGHATVASLYALCEKGMLESGKTYSIQTKA GILPVKISEKDGRIHITLEQASPQFKPFTGDRKKLADALGITDEDFHEDLPIVFGSTG IWTAIVPLKSLEASKKMVPDNKQFPEVLVDLPKASVHPFTFETVHPDSDLHGRHFSSP YSGTIEDPVTGTASGVMGAYMKHYGNAEQHKFIIEQGQEIGKDGKVEIEMNEAGGHVK VNMTGTAVYSETRILKI*" /label="yfhB CDS" gene 846843..847724 /gene="yfhB" /locus_tag="BSU_08470" /old_locus_tag="BSU08470" /label="yfhB gene" promotor_-35 847735..847742 /Source="Nicolas_upshift_promotors" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 847758..847777 /Source="Nicolas_upshift_promotors" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 847767 /Source="Nicolas_upshifts" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="upshifts" CDS 847812..848396 /gene="yfhC" /locus_tag="BSU_08480" /old_locus_tag="BSU08480" /EC_number="1.6.99.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12354229, 22287527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (nitroreductase family)" /protein_id="NP_388729.1" /db_xref="EnsemblGenomes-Gn:BSU08480" /db_xref="EnsemblGenomes-Tr:CAB12677" /db_xref="GOA:O31571" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR026021" /db_xref="InterPro:IPR029479" /db_xref="SubtiList:BG12878" /db_xref="UniProtKB/Swiss-Prot:O31571" /translation="MPQTEQIHQHSVLRDIIRSRRSIRKFKQEPVPSAVILDMLETAK YAPNHRVTEPWRFIYVSSETGKANLINTFAAFSKKSKPDMTEEKLQNFKNTLGRVPGF LLVVFQEDENERARDDDFAATSSLIQNLQLLAWEKGIGMVWKSGKILYDKEVHQAFGL QDNERFAAIIQTGYPDEAPEVKKRTPIRDRFTEM*" /label="yfhC CDS" gene 847812..848396 /gene="yfhC" /locus_tag="BSU_08480" /old_locus_tag="BSU08480" /label="yfhC gene" downshifts 848383 /Source="Nicolas_upshifts" /id="D422" /incds=0 /nref=208 /ntot=262 /MaxReadThrough="3.27483" /MaxDrop="6.40857" /score="21.7703837" /energy="-18.2" /TU="U645" /idTUdmin="U644" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(848435..848626) /gene="yfhD" /locus_tag="BSU_08490" /old_locus_tag="BSU08490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388730.1" /db_xref="EnsemblGenomes-Gn:BSU08490" /db_xref="EnsemblGenomes-Tr:CAB12678" /db_xref="InterPro:IPR025435" /db_xref="SubtiList:BG12879" /db_xref="UniProtKB/Swiss-Prot:O31572" /translation="MGRNHIHKNRDKNKQKLPQVPDALKRETDGVYEEYSTELADADD REAQERAKAADNRAKKKSR*" /label="yfhD CDS" gene complement(848435..848626) /gene="yfhD" /locus_tag="BSU_08490" /old_locus_tag="BSU08490" /label="yfhD gene" downshifts complement(848453) /Source="Nicolas_upshifts" /id="D423" /incds=0 /nref=65 /ntot=197 /MaxReadThrough="0.436919999999999" /MaxDrop="8.51174" /score="30.1998663" /energy="-18.2" /TU="NA" /idTUdmin="U649" /TUdmin=7 /isTUend="TRUE" /label="downshifts" upshifts complement(848658) /Source="Nicolas_upshifts" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(848661..848672) /Source="Nicolas_upshift_promotors" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(848687..848693) /Source="Nicolas_upshift_promotors" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(848693..848803) /gene="yfhE" /locus_tag="BSU_08500" /old_locus_tag="BSU08500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388731.1" /db_xref="EnsemblGenomes-Gn:BSU08500" /db_xref="EnsemblGenomes-Tr:CAB12679" /db_xref="InterPro:IPR025437" /db_xref="SubtiList:BG12880" /db_xref="UniProtKB/Swiss-Prot:O31573" /translation="MEKKREKHQQGANLKKMQEVLYSGEFKKAEKAAKRK*" /label="yfhE CDS" gene complement(848693..848803) /gene="yfhE" /locus_tag="BSU_08500" /old_locus_tag="BSU08500" /label="yfhE gene" promotor_-10 complement(848832..848843) /Source="Nicolas_upshift_promotors" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(848834) /Source="Nicolas_upshifts" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(848858..848864) /Source="Nicolas_upshift_promotors" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(848858..849769) /gene="yfhF" /locus_tag="BSU_08510" /old_locus_tag="BSU08510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleotide-or NAD-binding protein" /protein_id="NP_388732.1" /db_xref="EnsemblGenomes-Gn:BSU08510" /db_xref="EnsemblGenomes-Tr:CAB12680" /db_xref="GOA:O31574" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR010099" /db_xref="InterPro:IPR013549" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12881" /db_xref="UniProtKB/Swiss-Prot:O31574" /translation="MNIAMTGGTGFLGQHLTGVLTRQGHHVYILSRNARETEQKNMTY VQWLSEGAAPEQELPHIDVWINLAGKSIFGRWTEKTKQHILSSRINATREVQRLIQKQ KEKPKTLIQASAVGIYGTSLEKTFTEDSATSDEDFLSHTAHLWEKEGQHIEAMGIRTV YARFGVMLGEKGALPLMILPYKFLAGGTIGTGRQWLSWIHVEDAAQMIRYAVENAGIS GPMNVTAPNPVDMKQFGKTIARVKHRPHWLPVPEFFLSKALGEMSLLIVKGQRALPKK AITSGFRFTYSDLEFALSQLIADRKTV*" /label="yfhF CDS" gene complement(848858..849769) /gene="yfhF" /locus_tag="BSU_08510" /old_locus_tag="BSU08510" /label="yfhF gene" promotor_-35 849655..849658 /Source="Nicolas_upshift_promotors" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 849675..849694 /Source="Nicolas_upshift_promotors" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 849685..849857 /Source="Nicolas_S_feature" /locus_tag="new_925460_925632" /HighExp="LBGstat, Lbtran, T1.30H, T2.0H, T2.30H, M9-stat, T1.0H, T3.0H, Sw, G180" /AntisenseName="yfhF" /AntisenseCor="-5.3501479327985699E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S288" upshifts 849685 /Source="Nicolas_upshifts" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(849791..849809) /Source="Nicolas_upshift_promotors" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(849805) /Source="Nicolas_upshifts" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(849823..849829) /Source="Nicolas_upshift_promotors" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 849858..850652 /gene="recX" /locus_tag="BSU_08520" /old_locus_tag="BSU08520" /function="16.3: Control" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8946165, 10869079, 12547390, 23284295, 24285298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8946165, 10869079, 12547390, 23284295, 24285298; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulatory protein RecX" /protein_id="NP_388733.1" /db_xref="EnsemblGenomes-Gn:BSU08520" /db_xref="EnsemblGenomes-Tr:CAB12681" /db_xref="GOA:O31575" /db_xref="InterPro:IPR003783" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12882" /db_xref="UniProtKB/Swiss-Prot:O31575" /translation="MPFITKISTQKKNTERFNIFLDDKYAFSVDADVLVKFELKKGKE LDDLDIIEIQYGDEVKKGFNRALDFLSYRMRSTKEVEDHLKKKETSPPVIAEVIHRLN DYKYLNDQEFAAAYVSTHKKTNGKGPDVLFRELRAKGIDDDTIKEALSSFSFEDQTRE AVKHVEKLLKKDKKLSTKELKQRAQLQLQRKGFSFDVISAAMDQIEYENDEDTEKEAL RLHAEKAFRKYRYDGSYESAMKVKQFLFRKGFSLDLIEQLLQEEEY*" /label="recX CDS" gene 849858..850652 /gene="recX" /locus_tag="BSU_08520" /old_locus_tag="BSU08520" /label="recX gene" CDS 850654..850968 /gene="yfhH" /locus_tag="BSU_08530" /old_locus_tag="BSU08530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388734.1" /db_xref="EnsemblGenomes-Gn:BSU08530" /db_xref="EnsemblGenomes-Tr:CAB12682" /db_xref="InterPro:IPR014938" /db_xref="InterPro:IPR036289" /db_xref="PDB:1SF9" /db_xref="SubtiList:BG12883" /db_xref="UniProtKB/Swiss-Prot:O31576" /translation="MEKRYSQMTPHELNTEIALLSEKARKAEQHGIINELAVLERKIT MAKAYLLNPEDYSPGETYRVENTEDEFTISYLNGVFAWGYRTSSPQQEEALPISVLQE KE*" /label="yfhH CDS" gene 850654..850968 /gene="yfhH" /locus_tag="BSU_08530" /old_locus_tag="BSU08530" /label="yfhH gene" S_feature complement(850876..851144) /Source="Nicolas_S_feature" /locus_tag="new_926651_926919_c" /HighExp="S8, S6, S5, S7, C30, S4, nit, ferm, BT, G135" /AntisenseName="yfhH" /AntisenseCor="-0.53569713251514905" /AntisenseRegPval="-20.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S289" downshifts 850958 /Source="Nicolas_upshifts" /id="D424" /incds=0 /nref=71 /ntot=206 /MaxReadThrough="2.93348" /MaxDrop="5.2859" /score="24.7235138" /energy="-11.6" /TU="NA" /idTUdmin="U648" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 851042..851047 /Source="Nicolas_upshift_promotors" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 851063..851082 /Source="Nicolas_upshift_promotors" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 851068 /Source="Nicolas_upshifts" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="upshifts" CDS 851111..852304 /gene="yfhI" /locus_tag="BSU_08540" /old_locus_tag="BSU08540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388735.1" /db_xref="EnsemblGenomes-Gn:BSU08540" /db_xref="EnsemblGenomes-Tr:CAB12683" /db_xref="GOA:O31577" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12884" /db_xref="UniProtKB/Swiss-Prot:O31577" /translation="MSIKNPSVKFIIFVLMICTFSIGYTEYAVMGILTSIANDFHIQV SSAGLLVTAYAASVCLTGPLVTIISVKLPRKPVLLGLMAIFILSNLMSALAPNFAVLA ISRILSASIHGAFFAIAMVFASEMVPPEKRAAAAASMNGGLTVALMLGVPFGSYLGDV LNWRAVFSIITALGVIGFLGLMAAVPNRKPKVIPMLMNEWGVFKHKQVLFSFAITILG YSGVFIAYTFIEPILRHSAGFSTVGITGALFAYGLGGVAGNFFAGKVPLPLLTRTMIG VMIGLIGVLAVFPYIAIYPAAAIVATFLFGACAFGTPPLLQTKVISSSEGGTTIAAAV SVSAFNLANALGAWIGGMILNGTGSYSWLFAGGALMTACGLVLSTFAHLSEKKSVYEY QVNKG*" /label="yfhI CDS" gene 851111..852304 /gene="yfhI" /locus_tag="BSU_08540" /old_locus_tag="BSU08540" /label="yfhI gene" S_feature 852305..852539 /Source="Nicolas_S_feature" /locus_tag="new_928080_928314" /HighExp="G180, Paraq, C30, Oxctl, H2O2, G135, G150, S8, Heat, LBGstat" /AntisenseName="sspK" /AntisenseCor="1.9886505145521101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S290" CDS complement(852337..852489) /gene="sspK" /locus_tag="BSU_08550" /old_locus_tag="BSU08550" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054573.1" /db_xref="EnsemblGenomes-Gn:BSU08550" /db_xref="EnsemblGenomes-Tr:CAE01449" /db_xref="GOA:Q7WY75" /db_xref="InterPro:IPR012611" /db_xref="SubtiList:BG14175" /db_xref="UniProtKB/Swiss-Prot:Q7WY75" /translation="MVRNKEKGFPYENENKFQGEPRAKDDYASKRADGSINQHPQERM RASGKR*" /label="sspK CDS" gene complement(852337..852489) /gene="sspK" /locus_tag="BSU_08550" /old_locus_tag="BSU08550" /label="sspK gene" downshifts complement(852354) /Source="Nicolas_upshifts" /id="D425" /incds=0 /nref=24 /ntot=45 /MaxReadThrough="2.36419" /MaxDrop="4.9889" /score="20.2715496" /energy="-12.3" /TU="NA" /idTUdmin="U652" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 852518..852525 /Source="Nicolas_upshift_promotors" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 852539..852558 /Source="Nicolas_upshift_promotors" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 852541..852613 /Source="Nicolas_S_feature" /locus_tag="new_928316_928388" /HighExp="dia5, LPhT, Diami, dia15, Etha, T0.30H, H2O2, LBGstat, BC, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S291" upshifts 852541 /Source="Nicolas_upshifts" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(852548..852559) /Source="Nicolas_upshift_promotors" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(852558) /Source="Nicolas_upshifts" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(852574..852580) /Source="Nicolas_upshift_promotors" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 852614..852883 /gene="yfhJ" /locus_tag="BSU_08560" /old_locus_tag="BSU08560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388736.1" /db_xref="EnsemblGenomes-Gn:BSU08560" /db_xref="EnsemblGenomes-Tr:CAB12684" /db_xref="InterPro:IPR026952" /db_xref="SubtiList:BG12885" /db_xref="UniProtKB/Swiss-Prot:O31578" /translation="MNMYIEKLTNLLLEKNEMISYIQAKTWVELLWSDFEATYAKAGH AYQGEKMTEKIVTQWIENYGGQLHLFQSSRNDVNDYLNQSRGLLH*" /label="yfhJ CDS" gene 852614..852883 /gene="yfhJ" /locus_tag="BSU_08560" /old_locus_tag="BSU08560" /label="yfhJ gene" downshifts 852872 /Source="Nicolas_upshifts" /id="D426" /incds=0 /nref=62 /ntot=233 /MaxReadThrough="2.9538" /MaxDrop="5.3621" /score="19.3423239" /energy="-10.6" /TU="NA" /idTUdmin="U650" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 852961..852967 /Source="Nicolas_upshift_promotors" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 852982 /Source="Nicolas_upshifts" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 852983..853001 /Source="Nicolas_upshift_promotors" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 853028..853546 /gene="yfhK" /locus_tag="BSU_08570" /old_locus_tag="BSU08570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388737.1" /db_xref="EnsemblGenomes-Gn:BSU08570" /db_xref="EnsemblGenomes-Tr:CAB12685" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12886" /db_xref="UniProtKB/Swiss-Prot:O31579" /translation="MKKKQVMLALTAAAGLGLTALHSAPAAKAAPLHDISVSMPSSDT YIIKAGKLNVRTEPNHEGDILGTVSSEQKVKVDRFVNADWAQIHFKGKKAYISTHFLM KTASQAKTTKQTAFYTPTPENGKAKQLSSGTEVTILGWGFSENGGFDFTWAFVDYGGV KGYIHTKDLQMR*" /label="yfhK CDS" gene 853028..853546 /gene="yfhK" /locus_tag="BSU_08570" /old_locus_tag="BSU08570" /label="yfhK gene" S_feature 853547..853614 /Source="Nicolas_S_feature" /locus_tag="new_929322_929389" /HighExp="Etha, Sw, Salt, M9-stat, B60, B36, Gly, LoTm, BC, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S292" promotor_-35 853582..853591 /Source="Nicolas_upshift_promotors" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="promotor_-35" promotor_-10 853603..853618 /Source="Nicolas_upshift_promotors" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="promotor_-10" upshifts 853616 /Source="Nicolas_upshifts" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="upshifts" CDS 853631..853963 /gene="spdL" /locus_tag="BSU_08580" /old_locus_tag="BSU08580" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16629676, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor for peptide SdpC immunity" /protein_id="NP_388738.1" /db_xref="EnsemblGenomes-Gn:BSU08580" /db_xref="EnsemblGenomes-Tr:CAB12686" /db_xref="GOA:O31580" /db_xref="InterPro:IPR025962" /db_xref="SubtiList:BG12887" /db_xref="UniProtKB/Swiss-Prot:O31580" /translation="MTGLVGGGLMIIAGILIKLFPPKSINSVYGYRTRRSMSDQRLWN EANRYSASLMILSGLVIAGMGLLLGSNLFILQLILLIAACVITFMLTEKRLKIMTHSQ GGDRSGRS*" /label="spdL CDS" gene 853631..853963 /gene="spdL" /locus_tag="BSU_08580" /old_locus_tag="BSU08580" /label="spdL gene" CDS 853950..854810 /gene="ephM" /locus_tag="BSU_08590" /old_locus_tag="BSU08590" /EC_number="3.3.2.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16597997, 20941576" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16597997, 20941576; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="stress induced epoxide hydrolase" /protein_id="NP_388739.1" /db_xref="EnsemblGenomes-Gn:BSU08590" /db_xref="EnsemblGenomes-Tr:CAB12687" /db_xref="GOA:O31581" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12888" /db_xref="UniProtKB/Swiss-Prot:O31581" /translation="MDGVKCQFVNTNGITLHVAAAGREDGPLIVLLHGFPEFWYGWKN QIKPLVDAGYRVIAPDQRGYNLSDKPEGIDSYRIDTLRDDIIGLITQFTDEKAIVIGH DWGGAVAWHLASTRPEYLEKLIAINIPHPHVMKTVTPLYPPQWLKSSYIAYFQLPDIP EASLRENDYDTLDKAIGLSDRPALFTSEDVSRYKEAWKQPGALTAMLNWYRALRKGSL AEKPSYETVPYRMIWGMEDRFLSRKLAKETERHCPNGHLIFVDEASHWINHEKPAIVN QLILEYLKNQ*" /label="ephM CDS" gene 853950..854810 /gene="ephM" /locus_tag="BSU_08590" /old_locus_tag="BSU08590" /label="ephM gene" downshifts 854808 /Source="Nicolas_upshifts" /id="D427" /incds=0 /nref=27 /ntot=191 /MaxReadThrough="5.0793" /MaxDrop="4.1326" /score="3.7712168" /energy="-8.4" /TU="U653,U654" /idTUdmin="U654" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-35 854868..854874 /Source="Nicolas_upshift_promotors" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 854888..854899 /Source="Nicolas_upshift_promotors" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 854896..854960 /Source="Nicolas_S_feature" /locus_tag="new_930671_930735" /HighExp="Etha, S5, M9-stat, T0.30H, Sw, T-0.40H, B60, S8, B36, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigB" /TUshortPSig="0.99, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S293" upshifts 854896 /Source="Nicolas_upshifts" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(854918..854937) /Source="Nicolas_upshift_promotors" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(854927) /Source="Nicolas_upshifts" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 854943..854949 /Source="Nicolas_upshift_promotors" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(854951..854952) /Source="Nicolas_upshift_promotors" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 854962..855042 /Source="Nicolas_S_feature" /locus_tag="new_930737_930817" /HighExp="M9-stat, LBGexp, Lbexp, T0.30H, dia0, T1.30H, T1.0H, LBGtran, Paraq, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigGF, SigB" /TUshortPSig="1, 0.99, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S294" upshifts 854962 /Source="Nicolas_upshifts" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 854964..854982 /Source="Nicolas_upshift_promotors" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 855043..856032 /gene="csbB" /locus_tag="BSU_08600" /old_locus_tag="BSU08600" /EC_number="2.4.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8921856, 9636707, 23632331; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bactoprenol glycosyl transferase, phageorigin" /protein_id="NP_388740.1" /db_xref="EnsemblGenomes-Gn:BSU08600" /db_xref="EnsemblGenomes-Tr:CAB12688" /db_xref="GOA:Q45539" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11834" /db_xref="UniProtKB/Swiss-Prot:Q45539" /translation="MKQGLISIIIPSYNEGYNVKLIHESLKKEFKNIHYDYEIFFIND GSVDDTLQQIKDLAATCSRVKYISFSRNFGKEAAILAGFEHVQGEAVIVMDADLQHPT YLLKEFIKGYEEGYDQVIAQRNRKGDSFVRSLLSSMYYKFINKAVEVDLRDGVGDFRL LSRQAVNALLKLSEGNRFSKGLFCWIGFDQKIVFYENVERKNGTSKWSFSSLFNYGMD GVVSFNHKPLRLCFYTGIFILLLSIIYIIATFVKILTNGISVPGYFTIISAVLFLGGV QLLSLGIIGEYIGRIYYETKKRPHYLIKEANIPNKDLPETNELKSMRRLTKMH*" /label="csbB CDS" gene 855043..856032 /gene="csbB" /locus_tag="BSU_08600" /old_locus_tag="BSU08600" /label="csbB gene" upshifts complement(855192) /Source="Nicolas_upshifts" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(855197..855201) /Source="Nicolas_upshift_promotors" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(855218..855222) /Source="Nicolas_upshift_promotors" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 856033..856103 /Source="Nicolas_S_feature" /locus_tag="new_931808_931878" /HighExp="LPhT, Heat, Etha, LBGexp, M9-stat, LBGtran, Lbexp, Sw, dia0, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigB" /TUshortPSig="1, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S295" CDS 856104..858689 /gene="yfhO" /locus_tag="BSU_08610" /old_locus_tag="BSU08610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23632331; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388741.2" /db_xref="EnsemblGenomes-Gn:BSU08610" /db_xref="EnsemblGenomes-Tr:CAB12689" /db_xref="GOA:O31582" /db_xref="InterPro:IPR018580" /db_xref="SubtiList:BG12889" /db_xref="UniProtKB/Swiss-Prot:O31582" /translation="MKRKHIMIYAASLLVSVLAHAFFVKEWAEGRYMTGPGDGLAQMI VFKKLLFDQYTHGNFFYNYSFGLGGGTFSQLGYYFSASFLFLAVSAAVWLLQAVQLIG ETDTLFWAESAVFISIFKLSLIIFTSASVFHYLLKHRAASFTGAVLYGVSIIYFRHEA YWEFFTDTMVWLPLLVLGAEKIIRERRPAWFIVACSLTLINNFYFAYINLIFIGIYVL FRWLIRLEPHEEKRWIQIRLFLVSGFISFGISAAAFVPVVYGFLNNLRPPYSQKIEWL NFDDNILFSSRIIIVPAAFLLFLFIISFYKNRVFRLFAGLSLLFILFHFSPYAASVFN GFSAPQNRFEYVLAFTIAGAAAAGLSQLSELKRKELLPAAAVVLLLYLYHIQRYKLDI WKPANESILLLLLMTIAALFAAAFAKKRAKMAVYGIIILSSLFVANSYQKYALSEGGD LDSVTKEYLTSEEYRGRESSELIRRLQKEDDDPLMRIDWMNGVRNNTPIIYGFNGFSA YSSILNKDLLAFYWNDLSIDMGRESVSRYASLGDRANLYSLLYGKYYMTEKTNEASVP YGFKKHLETEHYAVYENQYMLPFVKTADAIYSESELDRLPALAKEQAMLKGIILKDPS GKTEQTPKPSNLITKSDITAKQAQYQNGLLTVTGENGGELIITPKQPSSAPGDYYVSF YLKSKAKDKGFTLKVNDYVTTRKSNKSIYKTGVNNITVRVPKSGHISINLPKGTYELR NIALYEENYQTLKNAVMQNKTEKADKLNWNKNRLTFSYHLSKDQYIMLPIPYEKGWEL KINGKTQKIEKADYAFIGFKAQKGDNHIELTYYPPYFKISAIISLVSLLLAVFYIRRK KPGSI*" /label="yfhO CDS" gene 856104..858689 /gene="yfhO" /locus_tag="BSU_08610" /old_locus_tag="BSU08610" /label="yfhO gene" downshifts 858658 /Source="Nicolas_upshifts" /id="D428" /incds=0 /nref=63 /ntot=217 /MaxReadThrough="2.13267" /MaxDrop="4.17784" /score="2.41489488" /energy="-13.3" /TU="NA" /idTUdmin="U657" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(858682..859665) /gene="yfhP" /locus_tag="BSU_08620" /old_locus_tag="BSU08620" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10463184, 10524235, 15849754, 16850406, 24237659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_388742.1" /db_xref="EnsemblGenomes-Gn:BSU08620" /db_xref="EnsemblGenomes-Tr:CAB12690" /db_xref="GOA:O31583" /db_xref="InterPro:IPR007404" /db_xref="SubtiList:BG12890" /db_xref="UniProtKB/Swiss-Prot:O31583" /translation="MDTGTHVVMGIALGGIATLDPVVGSDPAMAHAVMIATLAGSQAP DIDTVLKLKNNAVYIRNHRGFTHSIPAVLFWSVIIPAILYLFYPQADFLHLWLWTLLA VVLHVFVDIFNAYGTQAIRPFSKKWVALGLINTFDPFIFISHLAAIAIWYAGGSPGIT FLSLYIILVGYYLVRLIMQLRIKRKLHEMIHDEIESIIISPTMKFRQWRIAVTTAHAF YVGRSMEGHVVILDTFNRVPVPETDVMHAAKQDDNIAAFLSFSPVYRWEVDTFKDHYE VRFIDLRYRSKGHYPFVAIVHIGHDLTIRSSYTGWIFSEEKLQKKLKLGSI*" /label="yfhP CDS" gene complement(858682..859665) /gene="yfhP" /locus_tag="BSU_08620" /old_locus_tag="BSU08620" /label="yfhP gene" downshifts complement(858716) /Source="Nicolas_upshifts" /id="D429" /incds=0 /nref=28 /ntot=200 /MaxReadThrough="2.65266" /MaxDrop="4.43244" /score="25.5564412" /energy="-17.5" /TU="NA" /idTUdmin="U661" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 859139..859148 /Source="Nicolas_upshift_promotors" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 859161..859180 /Source="Nicolas_upshift_promotors" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 859165 /Source="Nicolas_upshifts" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(859666..859813) /Source="Nicolas_S_feature" /locus_tag="new_935441_935588_c" /HighExp="Diami, dia15, M9-stat, dia5, Etha, H2O2, S6, Salt, Lbtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S296" promotor_-35 859770..859774 /Source="Nicolas_upshift_promotors" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 859790..859809 /Source="Nicolas_upshift_promotors" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 859797 /Source="Nicolas_upshifts" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="upshifts" S_feature 859803..859880 /Source="Nicolas_S_feature" /locus_tag="new_935578_935655" /HighExp="H2O2, G150, G180, LBGstat, dia15, Diami, Oxctl, Paraq, G135, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S297" promotor_-10 complement(859811..859830) /Source="Nicolas_upshift_promotors" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(859813) /Source="Nicolas_upshifts" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(859845..859852) /Source="Nicolas_upshift_promotors" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 859881..860990 /gene="mutY" /locus_tag="BSU_08630" /old_locus_tag="BSU08630" /EC_number="3.2.2.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10463184, 20971907, 21954439, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10463184, 20971907, 21954439, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="A/G-specific adenine glycosylase or DNA-(apurinic or apyrimidinic site) lyase" /protein_id="NP_388743.1" /db_xref="EnsemblGenomes-Gn:BSU08630" /db_xref="EnsemblGenomes-Tr:CAB12691" /db_xref="GOA:O31584" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR003651" /db_xref="InterPro:IPR005760" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR023170" /db_xref="InterPro:IPR029119" /db_xref="SubtiList:BG12891" /db_xref="UniProtKB/Swiss-Prot:O31584" /translation="MNVLEDKLKQKDIQQFRDDLISWFEREQRVLPWREDQDPYKVWV SEVMLQQTRVETVIPYFLRFVEQFPTVEALADADEEKVLKAWEGLGYYSRVRNLQSAV KEVKQEYGGIVPPDEKDFGGLKGVGPYTKGAVLSIAYNKPIPAVDGNVMRVMSRILSI WDDIAKPKTRTIFEDAIRAFISKEKPSEFNQGLMELGALICTPKSPSCLLCPVQQHCS AFEEGTERELPVKSKKKKPGIKTMAAIVLTDEDGQVYIHKRPSKGLLANLWEFPNLET QKGIKTEREQLIAFLENEYGIQADISDLQGVVEHVFTHLVWNISVFFGKVKQVSDTSK LKKVTKEELEQFAFPVSHQKIWKMAGEAAAISAAP*" /label="mutY CDS" gene 859881..860990 /gene="mutY" /locus_tag="BSU_08630" /old_locus_tag="BSU08630" /label="mutY gene" promotor_-35 860827..860831 /Source="Nicolas_upshift_promotors" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 860847..860866 /Source="Nicolas_upshift_promotors" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 860859 /Source="Nicolas_upshifts" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="upshifts" S_feature 860991..861303 /Source="Nicolas_S_feature" /locus_tag="new_936766_937078" /HighExp="H2O2, G150, dia15, G135, G180, Oxctl, Paraq, dia0, LBGexp, Lbexp" /AntisenseName="yfhS" /AntisenseCor="-0.72611377663365595" /AntisenseRegPval="-44.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S298" CDS complement(860998..861222) /gene="yfhS" /locus_tag="BSU_08640" /old_locus_tag="BSU08640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10463184" /codon_start=1 /transl_table=11 /product="conserved protein related to sporulation" /protein_id="NP_388744.1" /db_xref="EnsemblGenomes-Gn:BSU08640" /db_xref="EnsemblGenomes-Tr:CAB12692" /db_xref="SubtiList:BG12892" /db_xref="UniProtKB/Swiss-Prot:O31585" /translation="MYVGRDMSELNMVSKKDWKNSELAYFHHAFQQIMPYLNEEGQSK YRELTQEIEARGGMKRNEADYSHGTRVSYD*" /label="yfhS CDS" gene complement(860998..861222) /gene="yfhS" /locus_tag="BSU_08640" /old_locus_tag="BSU08640" /label="yfhS gene" promotor_-10 complement(861252..861263) /Source="Nicolas_upshift_promotors" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(861254) /Source="Nicolas_upshifts" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(861277..861283) /Source="Nicolas_upshift_promotors" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 861304..862056 /gene="fabL" /locus_tag="BSU_08650" /old_locus_tag="BSU08650" /EC_number="1.3.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11007778, 12440970, 17329825, 21185310" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007778, 12440970, 17329825, 21185310; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-acyl carrier protein reductase III" /protein_id="NP_388745.1" /db_xref="EnsemblGenomes-Gn:BSU08650" /db_xref="EnsemblGenomes-Tr:CAB12693" /db_xref="GOA:P71079" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="PDB:3OIC" /db_xref="PDB:3OID" /db_xref="SubtiList:BG12221" /db_xref="UniProtKB/Swiss-Prot:P71079" /translation="MEQNKCALVTGSSRGVGKAAAIRLAENGYNIVINYARSKKAALE TAEEIEKLGVKVLVVKANVGQPAKIKEMFQQIDETFGRLDVFVNNAASGVLRPVMELE ETHWDWTMNINAKALLFCAQEAAKLMEKNGGGHIVSISSLGSIRYLENYTTVGVSKAA LEALTRYLAVELSPKQIIVNAVSGGAIDTDALKHFPNREDLLEDARQNTPAGRMVEIK DMVDTVEFLVSSKADMIRGQTIIVDGGRSLLV*" /label="fabL CDS" gene 861304..862056 /gene="fabL" /locus_tag="BSU_08650" /old_locus_tag="BSU08650" /label="fabL gene" promotor_-35 862073..862079 /Source="Nicolas_upshift_promotors" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 862094..862105 /Source="Nicolas_upshift_promotors" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 862095 /Source="Nicolas_upshifts" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(862102..862116) /Source="Nicolas_upshift_promotors" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(862123) /Source="Nicolas_upshifts" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(862125..862129) /Source="Nicolas_upshift_promotors" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 862125..862379 /gene="sspE" /locus_tag="BSU_08660" /old_locus_tag="BSU08660" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1744043, 7592342, 9540829, 19542328, 23314362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1744043, 7592342, 9540829, 19542328, 23314362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (gamma-type SASP)" /protein_id="NP_388746.1" /db_xref="EnsemblGenomes-Gn:BSU08660" /db_xref="EnsemblGenomes-Tr:CAB12694" /db_xref="GOA:P07784" /db_xref="InterPro:IPR006341" /db_xref="SubtiList:BG10789" /db_xref="UniProtKB/Swiss-Prot:P07784" /translation="MANSNNFSKTNAQQVRKQNQQSAAGQGQFGTEFASETNAQQVRK QNQQSAGQQGQFGTEFASETDAQQVRQQNQSAEQNKQQNS*" /label="sspE CDS" gene 862125..862379 /gene="sspE" /locus_tag="BSU_08660" /old_locus_tag="BSU08660" /label="sspE gene" downshifts 862377 /Source="Nicolas_upshifts" /id="D430" /incds=0 /nref=261 /ntot=269 /MaxReadThrough="1.59207" /MaxDrop="8.74804" /score="9.25353719" /energy="-9.5" /TU="NA" /idTUdmin="U660" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(862402) /Source="Nicolas_upshifts" /id="D431" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="1.21036" /MaxDrop="5.14076" /score="-9.78320441" /energy="-7.1" /TU="NA" /idTUdmin="U663" /TUdmin="-1687" /isTUend="FALSE" /label="downshifts" CDS 862468..862812 /gene="ygaB" /locus_tag="BSU_08670" /old_locus_tag="BSU08670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388747.1" /db_xref="EnsemblGenomes-Gn:BSU08670" /db_xref="EnsemblGenomes-Tr:CAB12695" /db_xref="InterPro:IPR025572" /db_xref="SubtiList:BG12222" /db_xref="UniProtKB/Swiss-Prot:P71080" /translation="MSQRVCFMEIEMIKGGNVYTFIRLKEEPMTEFEKLVSEQMKTMD KLLDLQSELDRCKQIEAELRHLERDARLRGIQAEIAVKRKHLADIQDMFQKQTEQVIR SYRSSEKPSSFV*" /label="ygaB CDS" gene 862468..862812 /gene="ygaB" /locus_tag="BSU_08670" /old_locus_tag="BSU08670" /label="ygaB gene" promotor_-35 862475..862483 /Source="Nicolas_upshift_promotors" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 862494..862512 /Source="Nicolas_upshift_promotors" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 862496 /Source="Nicolas_upshifts" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="upshifts" downshifts 862795 /Source="Nicolas_upshifts" /id="D432" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="4.84572" /MaxDrop="3.29993" /score="13.9694142" /energy="-11.5" /TU="U666" /idTUdmin="U660" /TUdmin=418 /isTUend="FALSE" /label="downshifts" promotor_-35 862851..862858 /Source="Nicolas_upshift_promotors" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 862872..862891 /Source="Nicolas_upshift_promotors" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 862881..862955 /Source="Nicolas_S_feature" /locus_tag="new_938656_938730" /HighExp="Etha, dia15, dia5, Diami, Salt, H2O2, BC, T5.0H, Cold, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S299" upshifts 862881 /Source="Nicolas_upshifts" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="upshifts" CDS 862956..863486 /gene="ygaC" /locus_tag="BSU_08680" /old_locus_tag="BSU08680" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19383706, 22333191; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding factor" /protein_id="NP_388748.3" /db_xref="EnsemblGenomes-Gn:BSU08680" /db_xref="EnsemblGenomes-Tr:CAB12696" /db_xref="InterPro:IPR007295" /db_xref="InterPro:IPR016882" /db_xref="InterPro:IPR035930" /db_xref="SubtiList:BG12223" /db_xref="UniProtKB/Swiss-Prot:Q796Z1" /translation="MGYPKEGETIQIHSYKHNGLIHRIWNETTILKSTEMCVIGANDR TMVTESDGRTWITREPAICYFHARQWFNVIGMLREDGVHYYCNISSPFAYDGEAIKYI DYDLDVKVFPDMTYNILDEDEYDDHRKAMNYPKEIDSILRDYLNTLLHWIHQRQGPFA PEFVDMWYERYLRYTK*" /label="ygaC CDS" gene 862956..863486 /gene="ygaC" /locus_tag="BSU_08680" /old_locus_tag="BSU08680" /label="ygaC gene" downshifts 863477 /Source="Nicolas_upshifts" /id="D433" /incds=0 /nref=8 /ntot=135 /MaxReadThrough="6.10669" /MaxDrop="3.97335" /score="-5.22328881" /energy="-7" /TU="U667" /idTUdmin="U666" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 863574..865316 /gene="ygaD" /locus_tag="BSU_08690" /old_locus_tag="BSU08690" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388749.2" /db_xref="EnsemblGenomes-Gn:BSU08690" /db_xref="EnsemblGenomes-Tr:CAB12697" /db_xref="GOA:P71082" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG12224" /db_xref="UniProtKB/Swiss-Prot:P71082" /translation="MGVMKRYMQFVKPYKKQIFVTVLIGIVKFSIPLALPLLLKYVVD DIIQGGGTASDKTTSLFTIMAIMFALFLILRPPVEYYRQYFAQWTASKVLYDIRAKLF DHIQKLSLRFYANTRTGEVISRVINDVEQTKDFVITGLMNIWLDMLTILIVISIMLTL DVKLTLISIVLFPLYGISVKYFYGRLRKLTRERSQALAQVQGHLHERIQGMPVIRSFA IEDHEQAQFNEKNGHFLDKAIRHTNWNAKTFAVVNTITDLAPLIVIACAGYFVINGPL TVGTMVAFVGYIDRMYNPVRRLINSSTTLTQSIASMDRVFEFIDEPYELTDKPNAIKA DQIRGGVEFQNVSFQYEKDKENILHDVSLKVNRGETVALVGMSGGGKSTLVSLIPRFY DVTSGRLLIDGTDIRDYEARSLRNQVGMVLQDTFLFSETIRENIAIGKPDATLEEIIE AAKAANAHEFIMSFPEGYETRVGERGVKLSGGQKQRISIARVFLKNPPLLILDEATSA LDLESEHYIQEAMDKLAKDRTTFVVAHRLSTITHADKIVVMENGTIIEIGTHDELMDY ESQYKHLFTIQNLN*" /label="ygaD CDS" gene 863574..865316 /gene="ygaD" /locus_tag="BSU_08690" /old_locus_tag="BSU08690" /label="ygaD gene" downshifts 865303 /Source="Nicolas_upshifts" /id="D434" /incds=0 /nref=87 /ntot=233 /MaxReadThrough="2.54676" /MaxDrop="5.20475" /score="22.3853226" /energy="-14.1" /TU="NA" /idTUdmin="U667" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(865393..866454) /gene="ygaE" /locus_tag="BSU_08700" /old_locus_tag="BSU08700" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388750.1" /db_xref="EnsemblGenomes-Gn:BSU08700" /db_xref="EnsemblGenomes-Tr:CAB12698" /db_xref="GOA:P71083" /db_xref="InterPro:IPR010343" /db_xref="SubtiList:BG12225" /db_xref="UniProtKB/Swiss-Prot:P71083" /translation="MKLGARIFKTGIAITLALYLASWIGLPAPIFAGIAAIFAIQPSI YRSFLIIIDQVQANIIGAVIATVFGLIFGPSPIMIGLTAVIVITIMLKLKIEHTISIA LVTVIAILESAGDDFLMFALIRTSTVILGVLSSFIVNLVFLPPKYETKLIHNTVENTE EIMKWIRLSMRQSTEHSILKEDIEKLKEKMIKLDQTYLLYKEERSYFKKTTYVKSRKL VLFRQAIITANRALDTLKKLHRLENEIYHMPEEFQETLTEELDYLLYWHERILMRFVG KIKPHDDAVEEGIRYKQLLTKSFLKNQQNTDEELIDYNMLNIMASAVEYREQLEHLET LITSFQTYHPKDCEIETEE*" /label="ygaE CDS" gene complement(865393..866454) /gene="ygaE" /locus_tag="BSU_08700" /old_locus_tag="BSU08700" /label="ygaE gene" downshifts complement(865404) /Source="Nicolas_upshifts" /id="D435" /incds=0 /nref=181 /ntot=254 /MaxReadThrough="1.1413" /MaxDrop="7.13599" /score="26.0617552" /energy="-9.4" /TU="NA" /idTUdmin="U668" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" S_feature complement(866455..866545) /Source="Nicolas_S_feature" /locus_tag="new_942230_942320_c" /HighExp="G180, Oxctl, Paraq, C30, G150, LBGexp, LPhT, S4, G135, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S300" promotor_-10 complement(866543..866562) /Source="Nicolas_upshift_promotors" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(866552) /Source="Nicolas_upshifts" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(866577..866584) /Source="Nicolas_upshift_promotors" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(866674..867963) /gene="gsaB" /locus_tag="BSU_08710" /old_locus_tag="BSU08710" /EC_number="5.4.3.8" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15231799, 19930658; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate-1-semialdehyde aminotransferase, classIII aminotransferase" /protein_id="NP_388751.3" /db_xref="EnsemblGenomes-Gn:BSU08710" /db_xref="EnsemblGenomes-Tr:CAB12699" /db_xref="GOA:P71084" /db_xref="InterPro:IPR004639" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11943" /db_xref="UniProtKB/Swiss-Prot:P71084" /translation="MHTKSIELHNEALQHIVGGVNSPSRSYKAVGGGSPVAMEKASGA YFWDVDGNKYIDYLAAYGPIITGHAHPHITEAIKKAAENGVLYGTPTKHEVTFAKMLK EAIPAMDKVRFVNSGTEAVMTTIRVARAYTGRTKIIKFAGCYHGHSDLVLVAAGSGPS TLGTPDSAGVPKSIANEVITVPFNDIDSYKAALEKWGSEIAAVLVEPIVGNFGIVEPK EGFLEQVNELTHNAGALVIYDEVITAFRFMYGGAQDLLQVKPDLTALGKIIGGGLPIG AYGGKQEIMEQVAPLGPAYQAGTMAGNPASILSGIACLEVLKEKGVYEKLDHLGAMLE EGILKHAETHGITITVNRLKGALTVYFSDEKVENYEQAERSDGETFSTFFKLMLERGI NLAPSKYEAWFITTAHTEQDIKDTLTAVEDAFKHLKN*" /label="gsaB CDS" gene complement(866674..867963) /gene="gsaB" /locus_tag="BSU_08710" /old_locus_tag="BSU08710" /label="gsaB gene" downshifts complement(866677) /Source="Nicolas_upshifts" /id="D436" /incds=0 /nref=235 /ntot=258 /MaxReadThrough="2.54961" /MaxDrop="5.8522" /score="29.5551149" /energy="-11" /TU="NA" /idTUdmin="U669" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(867991..868010) /Source="Nicolas_upshift_promotors" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(868010) /Source="Nicolas_upshifts" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(868012..868723) /Source="Nicolas_S_feature" /locus_tag="new_943787_944498_c" /HighExp="LoTm, M9-stat, B60, S8, C30, Cold, B36, T1.30H, Etha, T2.0H" /AntisenseName="ygaF" /AntisenseCor="-0.29702219161000198" /AntisenseRegPval="-6.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S301" promotor_-35 complement(868022..868027) /Source="Nicolas_upshift_promotors" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 868056..868063 /Source="Nicolas_upshift_promotors" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 868077..868096 /Source="Nicolas_upshift_promotors" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 868077 /Source="Nicolas_upshifts" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="upshifts" CDS 868116..868589 /gene="bcp" /locus_tag="BSU_08720" /old_locus_tag="BSU08720" /EC_number="1.11.1.15" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10644761, 11349039, 12950915, 21910476, 26723255; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxiredoxin with versatile activity" /protein_id="YP_054574.1" /db_xref="EnsemblGenomes-Gn:BSU08720" /db_xref="EnsemblGenomes-Tr:CAB12700" /db_xref="GOA:Q796Y8" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12226" /db_xref="UniProtKB/Swiss-Prot:Q796Y8" /translation="MTIEIGQKAPDLELKGDHGETVKLSDYKGKYIVLYFYPKDMTPG CTTEACDFRDSHESFAELDAVIIGVSPDSQEKHGKFKEKHNLPFLLLVDDEHKLAEAF DVWKLKKNFGKEYMGIERSTFLIDKEGRLIKEWRKVKVKDHVAEALQTLKDMSEK*" /label="bcp CDS" gene 868116..868589 /gene="bcp" /locus_tag="BSU_08720" /old_locus_tag="BSU08720" /label="bcp gene" promotor_-35 868626..868633 /Source="Nicolas_upshift_promotors" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 868648..868667 /Source="Nicolas_upshift_promotors" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 868654 /Source="Nicolas_upshifts" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="upshifts" CDS 868712..869149 /gene="perR" /locus_tag="BSU_08730" /old_locus_tag="BSU08730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1580225, 16541078, 16925555, 22194458, 27935957, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1580225, 16541078, 16925555, 22194458, 27935957, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Fur family)" /protein_id="NP_388753.1" /db_xref="EnsemblGenomes-Gn:BSU08730" /db_xref="EnsemblGenomes-Tr:CAB12701" /db_xref="GOA:P71086" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2FE3" /db_xref="PDB:2RGV" /db_xref="PDB:3F8N" /db_xref="SubtiList:BG12227" /db_xref="UniProtKB/Swiss-Prot:P71086" /translation="MAAHELKEALETLKETGVRITPQRHAILEYLVNSMAHPTADDIY KALEGKFPNMSVATVYNNLRVFRESGLVKELTYGDASSRFDFVTSDHYHAICENCGKI VDFHYPGLDEVEQLAAHVTGFKVSHHRLEIYGVCQECSKKENH*" /label="perR CDS" gene 868712..869149 /gene="perR" /locus_tag="BSU_08730" /old_locus_tag="BSU08730" /label="perR gene" downshifts 869131 /Source="Nicolas_upshifts" /id="D437" /incds=0 /nref=149 /ntot=247 /MaxReadThrough="3.98479" /MaxDrop="7.52234" /score="1.62878623" /energy="-12.3" /TU="U670,U671" /idTUdmin="U670" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(869184..869537) /gene="ygzB" /locus_tag="BSU_08740" /old_locus_tag="BSU08740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="YP_054575.1" /db_xref="EnsemblGenomes-Gn:BSU08740" /db_xref="EnsemblGenomes-Tr:CAE01450" /db_xref="GOA:Q7WY74" /db_xref="InterPro:IPR020912" /db_xref="SubtiList:BG14192" /db_xref="UniProtKB/Swiss-Prot:Q7WY74" /translation="MAKYSSKINKIRTFALSLVFVGFIIMYIGIFFKESVLLSSLFMI LGLLSIGLSTVVYFWIGMLSTKAVRVICPGCDKETKVLGVVDMCMHCREPLTLDKGLE GKEFDESYNKKKMSK*" /label="ygzB CDS" gene complement(869184..869537) /gene="ygzB" /locus_tag="BSU_08740" /old_locus_tag="BSU08740" /label="ygzB gene" downshifts 869197 /Source="Nicolas_upshifts" /id="D438" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="2.62283" /MaxDrop="4.13562" /score="-4.23596421" /energy="-12.5" /TU="NA" /idTUdmin="U670" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(869207) /Source="Nicolas_upshifts" /id="D439" /incds=0 /nref=182 /ntot=253 /MaxReadThrough="4.02571" /MaxDrop="6.23378" /score="9.51667757" /energy="-14.2" /TU="NA" /idTUdmin="U673" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 869533..869537 /Source="Nicolas_upshift_promotors" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="promotor_-35" promotor_-10 869545..869559 /Source="Nicolas_upshift_promotors" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="promotor_-10" misc_feature complement(869549..869568) /Source="Nicolas_upshift_promotors" /id="U673" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=432 /SigmaFactorBS="catatgtaaattccagttcaaccgaaaacatgaagaaaatcc catcgggttTGTGCTATAGTTAAAACAGAgggggatggacatggcgaaatactccagc a" /listShort="ygzB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 869549..869640 /Source="Nicolas_S_feature" /locus_tag="new_945324_945415" /HighExp="Cold, C30, H2O2, Etha, dia15, G135, Paraq, C90, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0739" /TUlongSig="NA" /TUlongPSig="NA" /label="S302" upshifts 869549 /Source="Nicolas_upshifts" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="upshifts" upshifts complement(869559) /Source="Nicolas_upshifts" /id="U673" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=432 /SigmaFactorBS="catatgtaaattccagttcaaccgaaaacatgaagaaaatcc catcgggttTGTGCTATAGTTAAAACAGAgggggatggacatggcgaaatactccagc a" /listShort="ygzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 869617..869620 /Source="Nicolas_upshift_promotors" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="promotor_-35" promotor_-10 869635..869654 /Source="Nicolas_upshift_promotors" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="promotor_-10" S_feature 869642..869744 /Source="Nicolas_S_feature" /locus_tag="new_945417_945519" /HighExp="BMM, Cold, LBGstat, C30, Oxctl, LBGexp, Paraq, G180, Lbexp, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.996, 0.0739" /TUlongSig="NA" /TUlongPSig="NA" /label="S303" upshifts 869642 /Source="Nicolas_upshifts" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="upshifts" CDS 869745..870629 /gene="ygxA" /locus_tag="BSU_08750" /old_locus_tag="BSU08750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388755.1" /db_xref="EnsemblGenomes-Gn:BSU08750" /db_xref="EnsemblGenomes-Tr:CAB12703" /db_xref="InterPro:IPR029348" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10951" /db_xref="UniProtKB/Swiss-Prot:Q04385" /translation="MENLLRPIYQERASHPNTLAVIMIERRNKTSSLTDNFDAALLVI VKDADEPVFIKHYEFDHQTASLHVVTDSQIQEWILLGTNRRIIDWIVNGRVLFDRNEY VVELIDRLNTFPFAERKLKIGLEYGKLIRRYVEGKAFFEANQFLDAYNAVVHALHHLA RIEVIDRGFHPETTVWSQVRQMEPQVYKLYSELIESHESLEKRLELLFLANDFLIHSK AEIGSAHLFEVMKEKDIWQFGELLQHHDLKHFTQDLGVMLDYLTEKGLINVCQIETKG QAVYHRGYSFKKGVDSDS*" /label="ygxA CDS" gene 869745..870629 /gene="ygxA" /locus_tag="BSU_08750" /old_locus_tag="BSU08750" /label="ygxA gene" promotor_-35 870612..870619 /Source="Nicolas_upshift_promotors" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 870633..870652 /Source="Nicolas_upshift_promotors" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 870648..870920 /Source="Nicolas_S_feature" /locus_tag="new_946423_946695" /HighExp="LBGstat, Oxctl, C30, Paraq, GM 120, H2O2, HPh, G150, LPh, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.106881" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="Sig-" /TUlongPSig="0.0739" /label="S304" upshifts 870648 /Source="Nicolas_upshifts" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(870681) /Source="Nicolas_upshifts" /id="D440" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="2.70619" /MaxDrop="3.85046" /score="4.43428373" /energy="-7.8" /TU="NA" /idTUdmin="U673" /TUdmin="-1474" /isTUend="FALSE" /label="downshifts" rRNA 870921..872475 /gene="rrnD-16S" /locus_tag="BSU_rRNA_22" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnD-16S rRNA" gene 870921..872475 /gene="rrnD-16S" /locus_tag="BSU_rRNA_22" /label="rrnD-16S gene" rRNA 872643..875570 /gene="rrnD-23S" /locus_tag="BSU_rRNA_17" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnD-23S rRNA" gene 872643..875570 /gene="rrnD-23S" /locus_tag="BSU_rRNA_17" /label="rrnD-23S gene" S_feature 875571..875656 /Source="Nicolas_S_feature" /locus_tag="new_951346_951431" /HighExp="G135, C30, Oxctl, Paraq, LBGstat, dia0, HiTm, Fru, G180, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S305" promotor_-35 875632..875639 /Source="Nicolas_upshift_promotors" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 875653..875672 /Source="Nicolas_upshift_promotors" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 875658 /Source="Nicolas_upshifts" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="upshifts" rRNA 875682..875797 /gene="rrnD-5S" /locus_tag="BSU_rRNA_18" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnD-5S rRNA" gene 875682..875797 /gene="rrnD-5S" /locus_tag="BSU_rRNA_18" /label="rrnD-5S gene" tRNA 875807..875881 /gene="asnTA" /locus_tag="BSU_tRNA_29" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="asparagine transfer RNA (GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="asnTA tRNA" gene 875807..875881 /gene="asnTA" /locus_tag="BSU_tRNA_29" /label="asnTA gene" tRNA 875887..875978 /gene="trnD-Ser" /locus_tag="BSU_tRNA_30" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(GGA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Ser tRNA" gene 875887..875978 /gene="trnD-Ser" /locus_tag="BSU_tRNA_30" /label="trnD-Ser gene" downshifts 875974 /Source="Nicolas_upshifts" /id="D441" /incds=0 /nref=2 /ntot=20 /MaxReadThrough="7.64297" /MaxDrop="4.37505" /score="-9.7424199" /energy="-11" /TU="U676" /idTUdmin="U677" /TUdmin="-1562" /isTUend="FALSE" /label="downshifts" tRNA 876013..876084 /gene="trnD-Glu" /locus_tag="BSU_tRNA_31" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Glu(UUC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Glu tRNA" gene 876013..876084 /gene="trnD-Glu" /locus_tag="BSU_tRNA_31" /label="trnD-Glu gene" tRNA 876094..876169 /gene="trnD-Val" /locus_tag="BSU_tRNA_32" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Val tRNA" gene 876094..876169 /gene="trnD-Val" /locus_tag="BSU_tRNA_32" /label="trnD-Val gene" tRNA 876179..876255 /gene="trnD-Met" /locus_tag="BSU_tRNA_33" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Met(CAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Met tRNA" gene 876179..876255 /gene="trnD-Met" /locus_tag="BSU_tRNA_33" /label="trnD-Met gene" tRNA 876267..876343 /gene="trnD-Asp" /locus_tag="BSU_tRNA_34" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asp(GUC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Asp tRNA" gene 876267..876343 /gene="trnD-Asp" /locus_tag="BSU_tRNA_34" /label="trnD-Asp gene" tRNA 876356..876431 /gene="trnD-Phe" /locus_tag="BSU_tRNA_35" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Phe(GAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Phe tRNA" gene 876356..876431 /gene="trnD-Phe" /locus_tag="BSU_tRNA_35" /label="trnD-Phe gene" tRNA 876437..876509 /gene="trnD-Thr" /locus_tag="BSU_tRNA_36" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Thr tRNA" gene 876437..876509 /gene="trnD-Thr" /locus_tag="BSU_tRNA_36" /label="trnD-Thr gene" tRNA 876532..876616 /gene="trnD-Tyr" /locus_tag="BSU_tRNA_37" /product="tRNA-Tyr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Tyr(GUA); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Tyr tRNA" gene 876532..876616 /gene="trnD-Tyr" /locus_tag="BSU_tRNA_37" /label="trnD-Tyr gene" tRNA 876622..876695 /gene="trnD-Trp" /locus_tag="BSU_tRNA_38" /product="tRNA-Trp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Trp(CCA); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Trp tRNA" gene 876622..876695 /gene="trnD-Trp" /locus_tag="BSU_tRNA_38" /label="trnD-Trp gene" tRNA 876720..876795 /gene="trnD-His" /locus_tag="BSU_tRNA_39" /product="tRNA-His" /inference="profile:tRNAscan:1.23" /note="transfer RNA-His(GUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-His tRNA" gene 876720..876795 /gene="trnD-His" /locus_tag="BSU_tRNA_39" /label="trnD-His gene" tRNA 876805..876876 /gene="trnD-Gln" /locus_tag="BSU_tRNA_40" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Gln tRNA" gene 876805..876876 /gene="trnD-Gln" /locus_tag="BSU_tRNA_40" /label="trnD-Gln gene" tRNA 876926..877000 /gene="glyTB" /locus_tag="BSU_tRNA_41" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="glycine transfer RNA (GCC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="glyTB tRNA" gene 876926..877000 /gene="glyTB" /locus_tag="BSU_tRNA_41" /label="glyTB gene" tRNA 877006..877076 /gene="cysTA" /locus_tag="BSU_tRNA_42" /product="tRNA-Cys" /inference="profile:tRNAscan:1.23" /note="cysteine tRNA (GCA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="cysTA tRNA" gene 877006..877076 /gene="cysTA" /locus_tag="BSU_tRNA_42" /label="cysTA gene" tRNA 877084..877172 /gene="leuTA" /locus_tag="BSU_tRNA_43" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="leucine RNA (UAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="leuTA tRNA" gene 877084..877172 /gene="leuTA" /locus_tag="BSU_tRNA_43" /label="leuTA gene" S_feature 877173..877249 /Source="Nicolas_S_feature" /locus_tag="new_952948_953024" /HighExp="Paraq, C30, Oxctl, G180, G135, Heat, BMM, LBGexp, dia15, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S306" downshifts 877206 /Source="Nicolas_upshifts" /id="D442" /incds=0 /nref=18 /ntot=231 /MaxReadThrough="5.36857" /MaxDrop="5.05259" /score="16.6649124" /energy="-8.9" /TU="U676" /idTUdmin="U677" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" S_feature 877251..877419 /Source="Nicolas_S_feature" /locus_tag="new_953026_953194" /HighExp="Heat, Paraq, BMM, Oxctl, H2O2, Cold, G180, Pyr, C30, Glu" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S307" promotor_-35 877376..877383 /Source="Nicolas_upshift_promotors" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 877382 /Source="Nicolas_upshifts" /id="D443" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="3.84674" /MaxDrop="3.439" /score="35.1424037" /energy="-12.4" /TU="U676" /idTUdmin="U677" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-10 877397..877416 /Source="Nicolas_upshift_promotors" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 877421 /Source="Nicolas_upshifts" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="upshifts" tRNA 877438..877519 /gene="leuTB" /locus_tag="BSU_tRNA_44" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="leucine tRNA(CAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="leuTB tRNA" gene 877438..877519 /gene="leuTB" /locus_tag="BSU_tRNA_44" /label="leuTB gene" promotor_-10 complement(877455..877472) /Source="Nicolas_upshift_promotors" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(877458) /Source="Nicolas_upshifts" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(877493..877498) /Source="Nicolas_upshift_promotors" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(877528) /Source="Nicolas_upshifts" /id="D444" /incds=0 /nref=5 /ntot=151 /MaxReadThrough="1.64364" /MaxDrop="6.28675" /score="7.71223568" /energy="-12.4" /TU="NA" /idTUdmin="U679" /TUdmin=18 /isTUend="TRUE" /label="downshifts" CDS complement(877598..878374) /gene="spo0M" /locus_tag="BSU_08760" /old_locus_tag="BSU08760" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9795118, 22142536, 26625291, 28234965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9795118, 22142536, 26625291, 28234965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="protein involved in the control of the cell cycle as a function of the environment" /protein_id="NP_388756.2" /db_xref="EnsemblGenomes-Gn:BSU08760" /db_xref="EnsemblGenomes-Tr:CAB12704" /db_xref="GOA:P71088" /db_xref="InterPro:IPR009776" /db_xref="InterPro:IPR014756" /db_xref="PDB:5CL2" /db_xref="SubtiList:BG12229" /db_xref="UniProtKB/Swiss-Prot:P71088" /translation="MSFFKKLAASAGIGAAKVDTILEKDAYFPGEEVQGTVHVKGGKI AQDIRYIDLQLSTRYVIVKDDEEHRKYATIHSFRVTGSFTIQPGEEHQFPFTFTLPLD TPITVGKVEVAVVTDLDIQGGIDKSDHDRIFVEAHPWIENVLEAIENLGFRLNEADCE QAPYFQRRLPFVQEFEFVPTSGYYRQMLDELELIFLLDEDGLEIIFEVDRRARGLRGW LEEMYNDGEQLVRVRFSQSELEDTEELEEVLEEILDQYAE*" /label="spo0M CDS" gene complement(877598..878374) /gene="spo0M" /locus_tag="BSU_08760" /old_locus_tag="BSU08760" /label="spo0M gene" downshifts complement(877612) /Source="Nicolas_upshifts" /id="D445" /incds=0 /nref=9 /ntot=131 /MaxReadThrough="6.06864" /MaxDrop="6.58787" /score="6.75662782" /energy="-7" /TU="U679" /idTUdmin="U679" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(878401..878416) /Source="Nicolas_upshift_promotors" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(878423) /Source="Nicolas_upshifts" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(878429..878438) /Source="Nicolas_upshift_promotors" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 878458..878464 /Source="Nicolas_upshift_promotors" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 878479..878490 /Source="Nicolas_upshift_promotors" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 878482 /Source="Nicolas_upshifts" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="upshifts" CDS 878516..878719 /gene="ygzA" /locus_tag="BSU_08770" /old_locus_tag="BSU08770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388757.2" /db_xref="EnsemblGenomes-Gn:BSU08770" /db_xref="EnsemblGenomes-Tr:CAB12705" /db_xref="SubtiList:BG12981" /db_xref="UniProtKB/Swiss-Prot:O31586" /translation="MEVNKESLVADELHRMFLAGELQITVEEDINNISERLRNGDLSL DRLSGEDVFIKETVNEALRRVEQ*" /label="ygzA CDS" gene 878516..878719 /gene="ygzA" /locus_tag="BSU_08770" /old_locus_tag="BSU08770" /label="ygzA gene" downshifts 878702 /Source="Nicolas_upshifts" /id="D446" /incds=0 /nref=22 /ntot=97 /MaxReadThrough="1.47004" /MaxDrop="5.47861" /score="15.4081475" /energy="-18.2" /TU="NA" /idTUdmin="U676" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(878778) /Source="Nicolas_upshifts" /id="D447" /incds=0 /nref=10 /ntot=35 /MaxReadThrough="1.31339" /MaxDrop="4.8918" /score="26.0684119" /energy="-18.2" /TU="NA" /idTUdmin="U681" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(878804..879076) /gene="ygzC" /locus_tag="BSU_08779" /old_locus_tag="BSU08779" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="YP_003097696.1" /db_xref="EnsemblGenomes-Gn:BSU08779" /db_xref="EnsemblGenomes-Tr:CAX52583" /db_xref="GOA:C0H3X8" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="UniProtKB/Swiss-Prot:C0H3X8" /translation="MYRSKKQSQILSYQELLKKQRRWFPIEQSLCPKDILDLLTTIKT SINKYTVATTATENPHIRRALHDQLDTAVYLHDELSDLLLEKGWLG*" /label="ygzC CDS" gene complement(878804..879076) /gene="ygzC" /locus_tag="BSU_08779" /old_locus_tag="BSU08779" /label="ygzC gene" promotor_-10 complement(879035..879053) /Source="Nicolas_upshift_promotors" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(879042) /Source="Nicolas_upshifts" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 879057..879064 /Source="Nicolas_upshift_promotors" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="promotor_-35" promotor_-35 complement(879070..879075) /Source="Nicolas_upshift_promotors" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 879077..879096 /Source="Nicolas_upshift_promotors" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="promotor_-10" upshifts 879085 /Source="Nicolas_upshifts" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="upshifts" CDS 879118..879810 /gene="ygaJ" /locus_tag="BSU_08780" /old_locus_tag="BSU08780" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peptidase" /protein_id="NP_388758.2" /db_xref="EnsemblGenomes-Gn:BSU08780" /db_xref="EnsemblGenomes-Tr:CAB12706" /db_xref="GOA:P71089" /db_xref="InterPro:IPR005320" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12230" /db_xref="UniProtKB/Swiss-Prot:P71089" /translation="MKQIIAMGGGGFSMEPDNLSLDQYILNQSKREQPRICFLPTASG DSQNYIQRFYHAFQTLDCVPSHLSLFKPPSSDLVSFVMEMDVIYVGGGNTRNLLVLWK EWGLDHILREAWKNGVVVAGISAGAICWFEEGVTDSAGPLTSLKSLGFLQGSFCPHYD GEKDRRPAYHQLISNKFLCSGYAADDGAALHFINDQLFQTVSSRSGAKAYRVMMAEHE IAEIPLPVKYLG*" /label="ygaJ CDS" gene 879118..879810 /gene="ygaJ" /locus_tag="BSU_08780" /old_locus_tag="BSU08780" /label="ygaJ gene" promotor_-35 879839..879843 /Source="Nicolas_upshift_promotors" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(879842..879861) /Source="Nicolas_upshift_promotors" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(879854) /Source="Nicolas_upshifts" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 879857..879876 /Source="Nicolas_upshift_promotors" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(879876..879883) /Source="Nicolas_upshift_promotors" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA 879880..879987 /gene="tswD" /locus_tag="BSU_misc_RNA_11" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswD RNA" gene 879880..879987 /gene="tswD" /locus_tag="BSU_misc_RNA_11" /label="tswD gene" upshifts 879887 /Source="Nicolas_upshifts" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="upshifts" downshifts 880018 /Source="Nicolas_upshifts" /id="D448" /incds=0 /nref=13 /ntot=48 /MaxReadThrough="8.09735" /MaxDrop="5.74046" /score="17.5556194" /energy="-12.4" /TU="U684" /idTUdmin="U682" /TUdmin=152 /isTUend="FALSE" /label="downshifts" CDS 880120..881892 /gene="thiC" /locus_tag="BSU_08790" /old_locus_tag="BSU08790" /EC_number="4.1.99.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8432721, 9370266, 10382260, 16291685, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8432721, 9370266, 10382260, 16291685, 26443755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphomethylpyrimidine synthase" /protein_id="NP_388759.2" /db_xref="EnsemblGenomes-Gn:BSU08790" /db_xref="EnsemblGenomes-Tr:CAB12707" /db_xref="GOA:P45740" /db_xref="InterPro:IPR002817" /db_xref="InterPro:IPR025747" /db_xref="SubtiList:BG11246" /db_xref="UniProtKB/Swiss-Prot:P45740" /translation="MQNNSVQQANISIMSSFSGSKKVYVEGSSSDIQVPMREIALSPT TGSFGEEENAPVRVYDTSGPYTDPEVTINIQEGLKPLRQKWITERGDVEEYEGRAIKP EDNGYKKAKPNVSYPGLKRKPLRAKAGQNVTQMHYAKKGIITPEMEFIAIREHVSPEF VRDEVASGRAIIPSNINHPESEPMIIGRNFHVKINANIGNSAVTSSIEEEVEKMTWAI RWGADTMMDLSTGKDIHTTREWIIRNCPVPVGTVPIYQALEKVNGVAEDLTWEIYRDT LIEQAEQGVDYFTIHAGVLLRYVPLTAKRTTGIVSRGGAIMAQWCLAHHQESFLYTHF EEICEIMKMYDIAFSLGDGLRPGSIADANDEAQFAELETLGELTQIAWKHDVQVMIEG PGHVPMHKIKENVDKQMDICKEAPFYTLGPLTTDIAPGYDHITSAIGAAMIGWYGTAM LCYVTPKEHLGLPNRDDVREGVITYKIAAHAADLAKGHPGAQIRDDALSKARFEFRWR DQFNLSLDPERALEYHDETLPAEGAKTAHFCSMCGPKFCSMRISQDIRDYAKKNDLSE AEAINKGLKEKAKEFVDTGSNLYQ*" /label="thiC CDS" gene 880120..881892 /gene="thiC" /locus_tag="BSU_08790" /old_locus_tag="BSU08790" /label="thiC gene" downshifts 881868 /Source="Nicolas_upshifts" /id="D449" /incds=0 /nref=166 /ntot=257 /MaxReadThrough="5.77069" /MaxDrop="5.3684" /score="25.2366359" /energy="-15.3" /TU="U684" /idTUdmin="U684" /TUdmin="-946" /isTUend="FALSE" /label="downshifts" S_feature 881913..882838 /Source="Nicolas_S_feature" /locus_tag="new_957688_958613" /HighExp="HiOs, GM-0.1, GM 45, GM 60, GM-0.2, BMM, MG 90, T-5.40H, MG 15, MG 25" /AntisenseName="ygaK" /AntisenseCor="-9.7288827054566707E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="SigA" /TUlongPSig=1 /label="S308" CDS complement(881930..883285) /gene="ygaK" /locus_tag="BSU_08800" /old_locus_tag="BSU08800" /EC_number="1.21.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8972604; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FAD-dependent oxido-reductase" /protein_id="NP_388760.2" /db_xref="EnsemblGenomes-Gn:BSU08800" /db_xref="EnsemblGenomes-Tr:CAB12708" /db_xref="GOA:Q796Y5" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR012951" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12231" /db_xref="UniProtKB/Swiss-Prot:Q796Y5" /translation="MEKTKLTGRIVTRDDPDYNEARTNINLSLERYPDIIVFCQNKQD ALNALKWARENRVPFRIRGGRHSYENFSLLNNGLVIDLSEMKKITVNQDKKLAYIEAG AELGEVYRTLWQYGLTLPAGTIANVGLTGLTLGGGIGLLTRAAGLTCDSLVQLEMIVA DEKEGADLITVSCSNHPDLFWASQGGGGGNFGIVTSMTFKAVPISQVSIFSITWGWDD FEEVYNTWQNWAPYTDDRLTSSIEFWPKEVNRIEALGQFVGPKTELKKLLKPLLKAGS PTSGMVKTTPFIEAVTFFNSPGGNQPQKMKRSGSFIEKPLSERAISTIKHFLEHAPNQ NASVWQQALGGAAGRVAPDQTAFYYRDAIIAQEYLTNWTSPGEKRQNVRWIEGLRTSL SKETMGDYVNWPDIEIRNWPRTYYGENVERLRRVKTTYDPENVFRFEQSIPPLRRSLF F*" /label="ygaK CDS" gene complement(881930..883285) /gene="ygaK" /locus_tag="BSU_08800" /old_locus_tag="BSU08800" /label="ygaK gene" promotor_-10 complement(883313..883332) /Source="Nicolas_upshift_promotors" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(883330) /Source="Nicolas_upshifts" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(883346..883355) /Source="Nicolas_upshift_promotors" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 883403..883409 /Source="Nicolas_upshift_promotors" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 883424..883443 /Source="Nicolas_upshift_promotors" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 883452 /Source="Nicolas_upshifts" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="upshifts" CDS 883536..883733 /gene="senS" /locus_tag="BSU_08810" /old_locus_tag="BSU08810" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1479343, 2108127, 8323536, 16321961" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1479343, 2108127, 8323536, 16321961; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (repressor of ScoC)" /protein_id="NP_388761.2" /db_xref="EnsemblGenomes-Gn:BSU08810" /db_xref="EnsemblGenomes-Tr:CAB12709" /db_xref="GOA:P21344" /db_xref="InterPro:IPR025004" /db_xref="SubtiList:BG10747" /db_xref="UniProtKB/Swiss-Prot:P21344" /translation="MGVKKEKGRKRFRKRKTYGNQILPLELLIEKNKREIINSAELME EIYMKIDEKHTQCVTKYKKTR*" /label="senS CDS" gene 883536..883733 /gene="senS" /locus_tag="BSU_08810" /old_locus_tag="BSU08810" /label="senS gene" CDS complement(883760..885211) /gene="katA" /locus_tag="BSU_08820" /old_locus_tag="BSU08820" /EC_number="1.11.1.6" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12029044, 12486061, 16535198, 22194458, 27935957" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12486061, 16535198, 22194458, 27935957; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="vegetative catalase 1" /protein_id="NP_388762.2" /db_xref="EnsemblGenomes-Gn:BSU08820" /db_xref="EnsemblGenomes-Tr:CAB12710" /db_xref="GOA:P26901" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024711" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG10849" /db_xref="UniProtKB/Swiss-Prot:P26901" /translation="MSSNKLTTSWGAPVGDNQNSMTAGSRGPTLIQDVHLLEKLAHFN RERVPERVVHAKGAGAHGYFEVTNDVTKYTKAAFLSEVGKRTPLFIRFSTVAGELGSA DTVRDPRGFAVKFYTEEGNYDIVGNNTPVFFIRDAIKFPDFIHTQKRDPKTHLKNPTA VWDFWSLSPESLHQVTILMSDRGIPATLRHMHGFGSHTFKWTNAEGEGVWIKYHFKTE QGVKNLDVNTAAKIAGENPDYHTEDLFNAIENGDYPAWKLYVQIMPLEDANTYRFDPF DVTKVWSQKDYPLIEVGRMVLDRNPENYFAEVEQATFSPGTLVPGIDVSPDKMLQGRL FAYHDAHRYRVGANHQALPINRARNKVNNYQRDGQMRFDDNGGGSVYYEPNSFGGPKE SPEDKQAAYPVQGIADSVSYDHYDHYTQAGDLYRLMSEDERTRLVENIVNAMKPVEKE EIKLRQIEHFYKADPEYGKRVAEGLGLPIKKDS*" /label="katA CDS" gene complement(883760..885211) /gene="katA" /locus_tag="BSU_08820" /old_locus_tag="BSU08820" /label="katA gene" downshifts complement(883770) /Source="Nicolas_upshifts" /id="D450" /incds=0 /nref=221 /ntot=261 /MaxReadThrough="1.32399" /MaxDrop="8.8938" /score="25.1548262" /energy="-8.3" /TU="NA" /idTUdmin="U688" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 885188..885194 /Source="Nicolas_upshift_promotors" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 885209..885228 /Source="Nicolas_upshift_promotors" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 885212 /Source="Nicolas_upshifts" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(885229..885248) /Source="Nicolas_upshift_promotors" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 885234..885563 /Source="Nicolas_S_feature" /locus_tag="new_961009_961338" /HighExp="S8, C30, S7, S6, BT, C90, B36, S4, S5, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.528" /TUlongSig="NA" /TUlongPSig="NA" /label="S309" upshifts complement(885248) /Source="Nicolas_upshifts" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(885262..885269) /Source="Nicolas_upshift_promotors" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(885307..885325) /Source="Nicolas_upshift_promotors" /id="U689" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.351648351648352" /psig="0.602397602397602" /xcortree=647 /SigmaFactorBS="gaaaaattatttctccaaaaattattaagtgtcataaaaagc tgttacaacaaggtttttcaacaatTTCGATACTATATATCGATtaatagagataact a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(885332) /Source="Nicolas_upshifts" /id="U689" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.351648351648352" /psig="0.602397602397602" /xcortree=647 /SigmaFactorBS="gaaaaattatttctccaaaaattattaagtgtcataaaaagc tgttacaacaaggtttttcaacaatTTCGATACTATATATCGATtaatagagataact a" /listShort="katA" /GFF_Attribute="listLong" /label="upshifts" downshifts 885520 /Source="Nicolas_upshifts" /id="D451" /incds=0 /nref=9 /ntot=21 /MaxReadThrough="5.89897" /MaxDrop="4.66837" /score="39.0049465" /energy="-19.7" /TU="U687" /idTUdmin="U686" /TUdmin=1936 /isTUend="FALSE" /label="downshifts" CDS 885619..886386 /gene="ssuB" /locus_tag="BSU_08830" /old_locus_tag="BSU08830" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type t: transporter" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (ATP-bindingprotein)" /protein_id="NP_388763.3" /db_xref="EnsemblGenomes-Gn:BSU08830" /db_xref="EnsemblGenomes-Tr:CAB12711" /db_xref="GOA:P97027" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR017875" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12232" /db_xref="UniProtKB/Swiss-Prot:P97027" /translation="MAVTISIKEKAFVQEGRKNTVLENIELSIAPGEFLTLIGPSGCG KSTLLKIIAGLDSEYDGSVEINGRSVTAPGIQQGFIFQEHRLFPWLTVEQNIAADLNL KDPKVKQKVDELIEIVRLKGSEKAYPRELSGGMSQRVAIARALLREPEVLLLDEPFGA LDAFTRKHLQDVLLDIWRKKKTTMILVTHDIDESVYLGNELAILKAKPGKIHKLMPIH LAYPRNRTTPDFQAIRQRVLSEFEKTEDLEYAEGSGI*" /label="ssuB CDS" gene 885619..886386 /gene="ssuB" /locus_tag="BSU_08830" /old_locus_tag="BSU08830" /label="ssuB gene" CDS 886404..887402 /gene="ssuA" /locus_tag="BSU_08840" /old_locus_tag="BSU08840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type f: factor" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (binding lipoprotein)" /protein_id="NP_388764.1" /db_xref="EnsemblGenomes-Gn:BSU08840" /db_xref="EnsemblGenomes-Tr:CAB12712" /db_xref="GOA:P40400" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR010067" /db_xref="InterPro:IPR015168" /db_xref="SubtiList:BG10656" /db_xref="UniProtKB/Swiss-Prot:P40400" /translation="MKKGLIVLVAVIFLLAGCGANGASGDHKQLKEIRIGIQQSLSPL LIAKEKGWFEDAFEKEGIKVKWVEFQSGPPQFEGLAADKLDFSQVGNSPVIAGQAAGI DFKEIGLSQDGLKANGILVNQNSGIQDVKGLKGKKIAVAKGSSGFDFLYKALDQVGLS ANDVTIIQLQPDEAASAFENGSVDAWSIWEPYLSLETMKHGAKILVNGESTDLYSPGF TLVRTKFSEEHPDEVVRFLKVFNKAVVWQKEHLDEAADLYSDIKDLDKKVVENVLKNT EPLNEIISDDIVKAQQETADFQFRTKAIDKKIDVKDVVDNTFIKKALEEHSSGGDQ*" /label="ssuA CDS" gene 886404..887402 /gene="ssuA" /locus_tag="BSU_08840" /old_locus_tag="BSU08840" /label="ssuA gene" CDS 887399..888229 /gene="ssuC" /locus_tag="BSU_08850" /old_locus_tag="BSU08850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11390694, 15849754, 16513748, 16850406, 16885442, 9782504" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 15849754, 16513748, 16850406, 16885442, 9782504; Product type t : transporter" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (permease)" /protein_id="NP_388765.1" /db_xref="EnsemblGenomes-Gn:BSU08850" /db_xref="EnsemblGenomes-Tr:CAB12713" /db_xref="GOA:P40401" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10657" /db_xref="UniProtKB/Swiss-Prot:P40401" /translation="MMKAEAAGSLPKTNAEAVRKKPGRKRYGWMKGLLLPAVIIAIWQ VIGGLGVVSATVLPTPVTIVLTFKELILSGELFGHLQISIYRAALGFLLGAGLGLMIG ILAGFSKRTELYLDPSLQMLRTVPHLAVTPLFILWFGFDEVSKILLIALGAFFPVYIN TFNGIRGVDAKLFEVARVLEFKWHQQISKVILPAALPNILLGIRLSLGIAWLGLVVAE LMGSSSGVGYMIMDARQFSQTNKVFAGIIIFAVVGKLTDSFVRLLERKLLKWRNSYEG *" /label="ssuC CDS" gene 887399..888229 /gene="ssuC" /locus_tag="BSU_08850" /old_locus_tag="BSU08850" /label="ssuC gene" CDS 888252..889382 /gene="ssuD" /locus_tag="BSU_08860" /old_locus_tag="BSU08860" /EC_number="1.14.14.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9782504, 11390694, 16513748, 16885442" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMNH2-dependent aliphatic sulfonate monooxygenase" /protein_id="NP_388766.2" /db_xref="EnsemblGenomes-Gn:BSU08860" /db_xref="EnsemblGenomes-Tr:CAB12714" /db_xref="GOA:P40402" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019911" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG10658" /db_xref="UniProtKB/Swiss-Prot:P40402" /translation="MEILWFIPTHGDARYLGSESDGRTADHLYFKQVAQAADRLGYTG VLLPTGRSCEDPWLTASALAGETKDLKFLVAVRPGLMQPSLAARMTSTLDRISDGRLL INVVAGGDPYELAGDGLFISHDERYEATDEFLTVWRRLLQGETVSYEGKHIKVENSNL LFPPQQEPHPPIYFGGSSQAGIEAAAKHTDVYLTWGEPPEQVKEKIERVKKQAAKEGR SVRFGIRLHVIARETEQEAWEAAERLISHLDDDTIAKAQAALSRYDSSGQQRMAVLHQ GDRTKLEISPNLWAGIGLVRGGAGTALVGDPQTIADRIAEYQALGIESFIFSGYPHLE EAYYFAELVFPLLPFENDRTRKLQNKRGEAVGNTYFVKEKNA*" /label="ssuD CDS" gene 888252..889382 /gene="ssuD" /locus_tag="BSU_08860" /old_locus_tag="BSU08860" /label="ssuD gene" misc_feature 889409..889428 /Source="Nicolas_upshift_promotors" /id="U690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.994005994005994" /xcortree=1467 /SigmaFactorBS="ttattttgtcaaagagaaaaatgcatgagtttaactaaaata cagccccccgaaCATGGTATGATATTCAAAAAaagggggctttttttctgaaaacatt g" /listShort="ygaN, S310" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 889415 /Source="Nicolas_upshifts" /id="U690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.994005994005994" /xcortree=1467 /SigmaFactorBS="ttattttgtcaaagagaaaaatgcatgagtttaactaaaata cagccccccgaaCATGGTATGATATTCAAAAAaagggggctttttttctgaaaacatt g" /listShort="ygaN, S310" /GFF_Attribute="listLong" /label="upshifts" CDS 889486..890022 /gene="ygaN" /locus_tag="BSU_08870" /old_locus_tag="BSU08870" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur-related oxidoreductase" /protein_id="NP_388767.1" /db_xref="EnsemblGenomes-Gn:BSU08870" /db_xref="EnsemblGenomes-Tr:CAB12715" /db_xref="SubtiList:BG12233" /db_xref="UniProtKB/Swiss-Prot:P97028" /translation="MLSACGHSKQMEIKAADISDLEKNRMDVAASQAFTAEAVNIGEG ISSADMYIEHYQKGKLVERFGPVRADYSEEKTDTIQFVYFENEEGEGKNKHTTIHFGI VDKQGTIAADSSVKRDDSTTQEMTQNISSPEPITFEKPALIGSSIRGTDETMHTSEHK KELIKHQDALLYYVELHH*" /label="ygaN CDS" gene 889486..890022 /gene="ygaN" /locus_tag="BSU_08870" /old_locus_tag="BSU08870" /label="ygaN gene" S_feature 890023..890093 /Source="Nicolas_S_feature" /locus_tag="new_965798_965868" /HighExp="B36, BT, B60, Etha, S5, Heat, S2, BMM, S4, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25357200000000002" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S310" promotor_-35 890063..890070 /Source="Nicolas_upshift_promotors" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 890084..890103 /Source="Nicolas_upshift_promotors" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 890095 /Source="Nicolas_upshifts" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="upshifts" CDS 890134..890403 /gene="rpsNB" /locus_tag="BSU_08880" /old_locus_tag="BSU08880" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12904577, 17163968, 19648245, 20208344, 27561249; Product type f: factor" /codon_start=1 /transl_table=11 /product="alternative ribosomal protein S14" /protein_id="NP_388768.1" /db_xref="EnsemblGenomes-Gn:BSU08880" /db_xref="EnsemblGenomes-Tr:CAB12716" /db_xref="GOA:O31587" /db_xref="InterPro:IPR001209" /db_xref="InterPro:IPR018271" /db_xref="InterPro:IPR023036" /db_xref="SubtiList:BG13085" /db_xref="UniProtKB/Swiss-Prot:O31587" /translation="MAKKSKVAKELKRQQLVEQYAGIRRELKEKGDYEALSKLPRDSA PGRLHNRCMVTGRPRAYMRKFKMSRIAFRELAHKGQIPGVKKASW*" /label="rpsNB CDS" gene 890134..890403 /gene="rpsNB" /locus_tag="BSU_08880" /old_locus_tag="BSU08880" /label="rpsNB gene" promotor_-35 890206..890210 /Source="Nicolas_upshift_promotors" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 890233..890249 /Source="Nicolas_upshift_promotors" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 890249 /Source="Nicolas_upshifts" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 890390 /Source="Nicolas_upshifts" /id="D452" /incds=0 /nref=41 /ntot=70 /MaxReadThrough="3.14088" /MaxDrop="6.23701" /score="18.4402235" /energy="-10.1" /TU="U692" /idTUdmin="U691" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" CDS complement(890421..890894) /gene="ygaO" /locus_tag="BSU_08890" /old_locus_tag="BSU08890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388769.1" /db_xref="EnsemblGenomes-Gn:BSU08890" /db_xref="EnsemblGenomes-Tr:CAB12717" /db_xref="GOA:P97029" /db_xref="SubtiList:BG12234" /db_xref="UniProtKB/Swiss-Prot:P97029" /translation="MSMKTKAAFHLVLFGLACWALISYFEASEGIASFFGTKSGGMVF DLNLTPFILFVAASAVYLYLQKKSRPARKQLLLPDEFEEQDEREQMMTAKACRASYIA VYFSLPAAAVLLIFYPLFQSRIPFFPIIIVFIIMIIQHLSYVISFKKNEKNSGAL*" /label="ygaO CDS" gene complement(890421..890894) /gene="ygaO" /locus_tag="BSU_08890" /old_locus_tag="BSU08890" /label="ygaO gene" downshifts complement(890457) /Source="Nicolas_upshifts" /id="D453" /incds=0 /nref=105 /ntot=235 /MaxReadThrough="1.59724" /MaxDrop="4.17785" /score="7.33161195" /energy="-10.1" /TU="NA" /idTUdmin="U693" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(890896..891096) /gene="ygzD" /locus_tag="BSU_08899" /old_locus_tag="BSU08899" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative HTH-type transcriptional regulator" /protein_id="YP_003097697.1" /db_xref="EnsemblGenomes-Gn:BSU08899" /db_xref="EnsemblGenomes-Tr:CAX52584" /db_xref="GOA:C0H3X9" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="UniProtKB/Swiss-Prot:C0H3X9" /translation="MKNKVKELRARFGYSQEKLGETVGVTRQTVAAIEKGDYVPSLLL ALKICKAFSMKMEDVFWLEEEN*" /label="ygzD CDS" gene complement(890896..891096) /gene="ygzD" /locus_tag="BSU_08899" /old_locus_tag="BSU08899" /label="ygzD gene" promotor_-10 complement(891125..891144) /Source="Nicolas_upshift_promotors" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(891139) /Source="Nicolas_upshifts" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(891157..891164) /Source="Nicolas_upshift_promotors" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 891220..891225 /Source="Nicolas_upshift_promotors" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 891239..891258 /Source="Nicolas_upshift_promotors" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 891239 /Source="Nicolas_upshifts" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="upshifts" tRNA 891290..891363 /gene="trnSL-Gly1" /locus_tag="BSU_tRNA_82" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(TCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Gly1 tRNA" gene 891290..891363 /gene="trnSL-Gly1" /locus_tag="BSU_tRNA_82" /label="trnSL-Gly1 gene" S_feature 891364..891546 /Source="Nicolas_S_feature" /locus_tag="new_967139_967321" /HighExp="G135, G180, Oxctl, G150, Paraq, H2O2, C30, HPh, LPh, LBGexp" /AntisenseName="yhzB" /AntisenseCor="0.42714037049296899" /AntisenseRegPval="-12.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S311" CDS complement(891454..892077) /gene="yhzB" /locus_tag="BSU_08900" /old_locus_tag="BSU08900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388771.1" /db_xref="EnsemblGenomes-Gn:BSU08900" /db_xref="EnsemblGenomes-Tr:CAB12718" /db_xref="InterPro:IPR020825" /db_xref="SubtiList:BG13086" /db_xref="UniProtKB/Swiss-Prot:O31588" /translation="MNIKLDSVITERAAGLHAAAVIYENIEVGSSPQMLKGRLRLFQE SLFFDYADGGISDESFVKEWQKLFKQLNPSFEGETTPMEDMLVPISKEQFMESKDSAH DTIDFFALKYSLPIMIYDAGKLHEPVRISLGEKENILLFSDENGIFGDFKNSVNHYPV SNETKNMLQIIFFPPSIEKSSAVNLLSSLTKMFEQIHGGTHTVHWLT*" /label="yhzB CDS" gene complement(891454..892077) /gene="yhzB" /locus_tag="BSU_08900" /old_locus_tag="BSU08900" /label="yhzB gene" downshifts complement(891469) /Source="Nicolas_upshifts" /id="D454" /incds=0 /nref=25 /ntot=165 /MaxReadThrough="2.50849" /MaxDrop="4.62652" /score="-8.52782087" /energy="-7.9" /TU="NA" /idTUdmin="U695" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 891503 /Source="Nicolas_upshifts" /id="D455" /incds=0 /nref=1 /ntot=88 /MaxReadThrough="4.14204" /MaxDrop="2.36986" /score="16.0836885" /energy="-15.5" /TU="U694" /idTUdmin="U692" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" S_feature 891548..892159 /Source="Nicolas_S_feature" /locus_tag="new_967323_967934" /HighExp="G180, G135, G150, Paraq, Oxctl, H2O2, LBGstat, Cold, LBGexp, S6" /AntisenseName="yhzB" /AntisenseCor="0.28959466335762701" /AntisenseRegPval="-5.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S312" promotor_-10 complement(892101..892120) /Source="Nicolas_upshift_promotors" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(892122) /Source="Nicolas_upshifts" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(892134..892141) /Source="Nicolas_upshift_promotors" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 892160..893320 /gene="queG" /locus_tag="BSU_08910" /old_locus_tag="BSU08910" /EC_number="1.17.99.-" /function="10.3: tRNA and rRNA base modification" /experiment="publication(s) with functional evidences, PMID:8830270, 21502530, 26230193, 27638883, 28128549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830270, 21502530, 26230193, 27638883, 28128549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="epoxyqueuosine reductase" /protein_id="NP_388772.2" /db_xref="EnsemblGenomes-Gn:BSU08910" /db_xref="EnsemblGenomes-Tr:CAB12719" /db_xref="GOA:P97030" /db_xref="InterPro:IPR004155" /db_xref="InterPro:IPR004453" /db_xref="InterPro:IPR013542" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="PDB:5D08" /db_xref="PDB:5D0A" /db_xref="PDB:5D0B" /db_xref="PDB:5T8Y" /db_xref="SubtiList:BG12236" /db_xref="UniProtKB/Swiss-Prot:P97030" /translation="MNVYQLKEELIEYAKSIGVDKIGFTTADTFDSLKDRLILQESLG YLSGFEEPDIEKRVTPKLLLPKAKSIVAIALAYPSRMKDAPRSTRTERRGIFCRASWG KDYHDVLREKLDLLEDFLKSKHEDIRTKSMVDTGELSDRAVAERAGIGFSAKNCMITT PEYGSYVYLAEMITNIPFEPDVPIEDMCGSCTKCLDACPTGALVNPGQLNAQRCISFL TQTKGFLPDEFRTKIGNRLYGCDTCQTVCPLNKGKDFHLHPEMEPDPEIAKPLLKPLL AISNREFKEKFGHVSGSWRGKKPIQRNAILALAHFKDASALPELTELMHKDPRPVIRG TAAWAIGKIGDPAYAEELEKALEKEKDEEAKLEIEKGIELLKASGMTKQGLS*" /label="queG CDS" gene 892160..893320 /gene="queG" /locus_tag="BSU_08910" /old_locus_tag="BSU08910" /label="queG gene" downshifts 893329 /Source="Nicolas_upshifts" /id="D456" /incds=0 /nref=9 /ntot=123 /MaxReadThrough="5.29174" /MaxDrop="3.3561" /score="33.0421154" /energy="-15.1" /TU="NA" /idTUdmin="U694" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 893346..893358 /Source="Nicolas_upshift_promotors" /id="U696" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1143 /SigmaFactorBS="tcaggcatgactaaacaaggcctgtcctgacatacgtataga gcagaaggaaaaaACACTTGAGATCAtccaagtgttttttctctataaaaaagtatgg c" /listShort="yhbB, cspR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 893351 /Source="Nicolas_upshifts" /id="U696" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1143 /SigmaFactorBS="tcaggcatgactaaacaaggcctgtcctgacatacgtataga gcagaaggaaaaaACACTTGAGATCAtccaagtgttttttctctataaaaaagtatgg c" /listShort="yhbB, cspR" /GFF_Attribute="listLong" /label="upshifts" CDS 893387..894322 /gene="yhbB" /locus_tag="BSU_08920" /old_locus_tag="BSU08920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388773.1" /db_xref="EnsemblGenomes-Gn:BSU08920" /db_xref="EnsemblGenomes-Tr:CAB12720" /db_xref="InterPro:IPR024301" /db_xref="SubtiList:BG11811" /db_xref="UniProtKB/Swiss-Prot:O31589" /translation="MAGGVSLKYILEQLAEERLGFLVNGHAMRQESQVGDLKVMERKK KLLEKRKVDIIKAKAKAVINHVRVEDDGTTCLSYTIHYEYVCKEQDDSLYIEEHIEER MAFLYDHILISDQEIAKKPAGFHEGTSIIDYSEAEEEREAFGRAFQYDRLGAVQYAEK FWNKRNPAYKNFSDNCTNFISQCLHAGGAPMRGHPNRGSGWWMKQSSWSYSWTVAHSM KMYLSNSKAGLRAVRVKSAEELMPGDVICYDFEGDGRFNHTTIVVAKDKGNMPLVNAQ TYDSRMRYWSYEDSTAYTPSIRYAFFHIVDDTTKE*" /label="yhbB CDS" gene 893387..894322 /gene="yhbB" /locus_tag="BSU_08920" /old_locus_tag="BSU08920" /label="yhbB gene" downshifts complement(893405) /Source="Nicolas_upshifts" /id="D457" /incds=0 /nref=2 /ntot=17 /MaxReadThrough="2.06584" /MaxDrop="3.33944" /score="-3.35852865" /energy="-6" /TU="NA" /idTUdmin="U695" /TUdmin="-1936" /isTUend="FALSE" /label="downshifts" promotor_-35 894306..894309 /Source="Nicolas_upshift_promotors" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 894324 /Source="Nicolas_upshifts" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 894325..894344 /Source="Nicolas_upshift_promotors" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 894360..894842 /gene="trmL" /locus_tag="BSU_08930" /old_locus_tag="BSU08930" /EC_number="2.1.1.207" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 20855540; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (cytidine(34)-2'-O)-methyltransferase" /protein_id="NP_388774.2" /db_xref="EnsemblGenomes-Gn:BSU08930" /db_xref="EnsemblGenomes-Tr:CAB12721" /db_xref="GOA:O31590" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR016914" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="SubtiList:BG11802" /db_xref="UniProtKB/Swiss-Prot:O31590" /translation="MNIVALHVVLYQPEIPANTGNIARTCAATNTTLHLIRPLGFSTD DKMLKRAGLDYWEFVNVVYHDSLEELFEAYKKGKFFFITKFGQQPHTSFDYTDLDEDY FFVFGRETSGLPKDLIQNNMDRCLRLPMTEHVRSLNLSNTAAILVYEALRQQNYRDLK *" /label="trmL CDS" gene 894360..894842 /gene="trmL" /locus_tag="BSU_08930" /old_locus_tag="BSU08930" /label="trmL gene" downshifts 894825 /Source="Nicolas_upshifts" /id="D458" /incds=0 /nref=203 /ntot=259 /MaxReadThrough="4.6846" /MaxDrop="7.03587" /score="33.0421154" /energy="-15.1" /TU="NA" /idTUdmin="U696" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 894892..895608 /gene="yhbD" /locus_tag="BSU_08940" /old_locus_tag="BSU08940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein" /protein_id="NP_388775.1" /db_xref="EnsemblGenomes-Gn:BSU08940" /db_xref="EnsemblGenomes-Tr:CAB12722" /db_xref="InterPro:IPR025063" /db_xref="SubtiList:BG12237" /db_xref="UniProtKB/Swiss-Prot:P97032" /translation="MLCFVFGLNNVTVLCYNVPIKGAGLMEEQLISKKELLERTSISY GQLYRWKRKNLIPEEWFIRKSTFTGQETFFPREEILKRISMIQKMKENLSLDEMREML SPKMKDVSMTADELLHKGLVSRPALEAYSEDGGSPVFSSSDLLSLFVLEGLLQSGNVS LAEAKMAAEVLKKHDTEEIEKQTELIVLRKLGVTTCFIAAAADSILFESSVKVVERVD LLKASEELKTTFMQEGHQWM*" /label="yhbD CDS" gene 894892..895608 /gene="yhbD" /locus_tag="BSU_08940" /old_locus_tag="BSU08940" /label="yhbD gene" promotor_-35 894912..894919 /Source="Nicolas_upshift_promotors" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 894934..894953 /Source="Nicolas_upshift_promotors" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 894935 /Source="Nicolas_upshifts" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="upshifts" CDS 895599..896312 /gene="yhbE" /locus_tag="BSU_08950" /old_locus_tag="BSU08950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816, 20617312; Product type cp:cell process" /codon_start=1 /transl_table=11 /product="conserved protein involved in sporulation" /protein_id="NP_388776.1" /db_xref="EnsemblGenomes-Gn:BSU08950" /db_xref="EnsemblGenomes-Tr:CAB12723" /db_xref="InterPro:IPR007607" /db_xref="SubtiList:BG10802" /db_xref="UniProtKB/Swiss-Prot:P39132" /translation="MDVVEKLVINGSGSSKGGTFQSVEINGSGTVAGDVECDTFSFNG NGKADGSVKAKAVTISGSGKIHGDVEAESIRMNGTGFIQGEVSAKQLKIAGSSTFGGT VKADGIDISGKAVMEADCETETFQSEGKCKISGLLNADQVIIKLSAGESYAREIGCRH LQVTCRKGMLTLLRLMPQPVLTAELIEGDVIELTNTKAKTVRGNKVIIGPDCQIETVE YSGDYTCDPSASVETSTKL*" /label="yhbE CDS" gene 895599..896312 /gene="yhbE" /locus_tag="BSU_08950" /old_locus_tag="BSU08950" /label="yhbE gene" CDS 896324..897031 /gene="yhbF" /locus_tag="BSU_08960" /old_locus_tag="BSU08960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816, 20617312; Product type cp:cell process" /codon_start=1 /transl_table=11 /product="conserved protein involved in sporulation" /protein_id="NP_388777.2" /db_xref="EnsemblGenomes-Gn:BSU08960" /db_xref="EnsemblGenomes-Tr:CAB12724" /db_xref="SubtiList:BG10803" /db_xref="UniProtKB/Swiss-Prot:P39133" /translation="METTKLGNLKLYGAGHAAGGAYHNVSIKGEGIVGEGLSAVGCRI YGTGLFLGKAETERLRVLGESECKGDLTAGKINIYGTMKVSGSLQFDRFNLKGQTEIG GNMTGESCDVKGKLSVIGDCETEMFHVTGCVDVSGLLNSGEIKLGLSHDISHVQEIGG TTITVKRRASFFSRKKGKLIADVIEGDRVYLENTEAAVVRGKEVIIGPGCSIGTIEYE YKCECDPHSQIKEKTKL*" /label="yhbF CDS" gene 896324..897031 /gene="yhbF" /locus_tag="BSU_08960" /old_locus_tag="BSU08960" /label="yhbF gene" downshifts 896915 /Source="Nicolas_upshifts" /id="D459" /incds=1 /nref=1 /ntot=127 /MaxReadThrough="4.34704" /MaxDrop="2.64409" /score="45.497414" /energy="-15.3" /TU="U698" /idTUdmin="U698" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 896959 /Source="Nicolas_upshifts" /id="D460" /incds=1 /nref=2 /ntot=35 /MaxReadThrough="4.02504" /MaxDrop="3.21894" /score="45.497414" /energy="-15.3" /TU="U698" /idTUdmin="U698" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 897025 /Source="Nicolas_upshifts" /id="D461" /incds=0 /nref=2 /ntot=41 /MaxReadThrough="1.06365" /MaxDrop="3.74046" /score="45.497414" /energy="-15.3" /TU="NA" /idTUdmin="U698" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(897058..897233) /Source="Nicolas_S_feature" /locus_tag="new_972833_973008_c" /HighExp="M9-stat, BC, S4, T0.30H, LoTm, Lbstat, S2, BT, HiOs, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99846699999999999" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S313" downshifts complement(897101) /Source="Nicolas_upshifts" /id="D462" /incds=0 /nref=63 /ntot=220 /MaxReadThrough="3.38525" /MaxDrop="4.33005" /score="18.2489321" /energy="-13.5" /TU="U699" /idTUdmin="U699" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(897225..897244) /Source="Nicolas_upshift_promotors" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(897233) /Source="Nicolas_upshifts" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(897259..897266) /Source="Nicolas_upshift_promotors" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 897298..897303 /Source="Nicolas_upshift_promotors" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 897319..897337 /Source="Nicolas_upshift_promotors" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 897319 /Source="Nicolas_upshifts" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="upshifts" CDS 897381..899276 /gene="prkA" /locus_tag="BSU_08970" /old_locus_tag="BSU08970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8626065, 12662922, 25983726, 27806131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8626065, 12662922, 25983726, 27806131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine protein kinase (involved in sporulation)" /protein_id="NP_388778.1" /db_xref="EnsemblGenomes-Gn:BSU08970" /db_xref="EnsemblGenomes-Tr:CAB12725" /db_xref="GOA:P39134" /db_xref="InterPro:IPR010650" /db_xref="InterPro:IPR013153" /db_xref="InterPro:IPR016230" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10804" /db_xref="UniProtKB/Swiss-Prot:P39134" /translation="MDILKKIEKYREEEQRLKWEGTFADYLEIIKENPMVAQSAHSRV FNMIKDSGIEEIDGRKKYSFFDRELFGLEESLERLVEEYFHPAAKRLDVRKRILLLMG PVSGGKSTLVTMLKKGLEAYTLTDNGAVYAIKGCPMHEDPLHLIPHHLRDDFYREYGI RIEGSLSPLNVMRLEEEYGGRIEDVKVERIFFSEDKRTGIGTFSPSDPKSQDIADLTG SIDFSTIAEYGSESDPRAYRFDGELNKANRGMMEFQEMLKCDEKFLWHLLSLTQEGNF KAGRFALISADELIVAHTNETEYRSFISNKKNEALHSRIIVMPVPYNLKVSEEERIYE KMIAESDVADVHIAPHTLKVAAMFSILTRLKEPKRSDIDLVKKMRLYDGESVEGYNSV DVEDMKKEYNDEGMSGIDPRYVINRISSTIIRKNMESINSLDVLRSLKEGLDQHPSIS SEDRERYLNFISAARKEYDDIAKKEVQKAFVYSYEESAKTLMDNYLDNVEAYCNKNKL RDPLTGEEMNPDEKLMRSIEEQIGISENAKKAFREEILIRISAYARKGKRFDYNSHER LREAIQKKLFADLKDVVKITTSTKTPDEQQLKKVNEVVARLIDEHGYNSTSANELLKY VGSLLNR*" /label="prkA CDS" gene 897381..899276 /gene="prkA" /locus_tag="BSU_08970" /old_locus_tag="BSU08970" /label="prkA gene" promotor_no_box 897823..897923 /Source="Nicolas_upshift_promotors" /id="U701" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.31968031968032" /psig="0.31968031968032" /xcortree=684 /SigmaFactorBS="atcatttacgcgatgacttttacagagaatacggcattagaa tagaaggaagtctttctcctttaaatgtcatgaggctggaggaagagtacggaggaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 897883 /Source="Nicolas_upshifts" /id="U701" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.31968031968032" /psig="0.31968031968032" /xcortree=684 /SigmaFactorBS="atcatttacgcgatgacttttacagagaatacggcattagaa tagaaggaagtctttctcctttaaatgtcatgaggctggaggaagagtacggaggaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 897949 /Source="Nicolas_upshifts" /id="D463" /incds=1 /nref=5 /ntot=18 /MaxReadThrough="7.33384" /MaxDrop="5.65132" /score="45.497414" /energy="-15.3" /TU="U700" /idTUdmin="U701" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 899269 /Source="Nicolas_upshifts" /id="D464" /incds=0 /nref=11 /ntot=57 /MaxReadThrough="6.19375" /MaxDrop="4.381" /score="-0.497429548" /energy="-10.6" /TU="U700" /idTUdmin="U703" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-35 899333..899338 /Source="Nicolas_upshift_promotors" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 899354..899372 /Source="Nicolas_upshift_promotors" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 899357..899455 /Source="Nicolas_S_feature" /locus_tag="new_975132_975230" /HighExp="S6, S7, S5, S8, S4, S3, BT, LoTm, B36, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.971, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S314" upshifts 899357 /Source="Nicolas_upshifts" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="upshifts" CDS 899456..900634 /gene="yhbH" /locus_tag="BSU_08980" /old_locus_tag="BSU08980" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11988534, 12662922, 14523133, 25983726" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11988534, 12662922, 14523133, 25983726; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination" /protein_id="NP_388779.1" /db_xref="EnsemblGenomes-Gn:BSU08980" /db_xref="EnsemblGenomes-Tr:CAB12726" /db_xref="InterPro:IPR006698" /db_xref="InterPro:IPR014230" /db_xref="SubtiList:BG11238" /db_xref="UniProtKB/Swiss-Prot:P45742" /translation="MSQNDSGHFLISEENWSLHRKGFDDQQRHQKKVQEAIKNNLPDL VTEESIIMSNGKDVVKIPIRSLDEYKIRYNYDKNKHVGQGDGESQVGDVVARDGSDKK QGPGKGQGAGDQAGEDYYEAEVSLMDLEEALFKELELPNLQQKERDNIIHTDIEFNDI RKTGLTGNIDKKRTMMSAFKRNAMSGKPSFYPIYPEDLKYKTWNDITKPESKAVVLAM MDTSGSMGVWEKYMARSFFFWMTRFLRTKYETVEIEFIAHHTEARVVSEEDFFSKGES GGTICSSVYRKSLELIDEKYNPARYNIYPFHFSDGDNLTSDNARCVKLVNDIMKKANL FCYGEVNQYNRHSTLMSAYKNVKDEKFKYYILKQKSDVFQALKNFFRNEESGVSHQFS *" /label="yhbH CDS" gene 899456..900634 /gene="yhbH" /locus_tag="BSU_08980" /old_locus_tag="BSU08980" /label="yhbH gene" promotor_-35 899654..899657 /Source="Nicolas_upshift_promotors" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 899672..899691 /Source="Nicolas_upshift_promotors" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 899676 /Source="Nicolas_upshifts" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(899917) /Source="Nicolas_upshifts" /id="D465" /incds=1 /nref=1 /ntot=23 /MaxReadThrough="2.79078" /MaxDrop="2.94521" /score="-7.1109433" /energy="-11.2" /TU="NA" /idTUdmin="U699" /TUdmin="-3014" /isTUend="FALSE" /label="downshifts" downshifts 900613 /Source="Nicolas_upshifts" /id="D466" /incds=0 /nref=63 /ntot=180 /MaxReadThrough="1.86673" /MaxDrop="8.19565" /score="27.3980811" /energy="-5.6" /TU="NA" /idTUdmin="U702" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 900721..900728 /Source="Nicolas_upshift_promotors" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 900743..900762 /Source="Nicolas_upshift_promotors" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 900743 /Source="Nicolas_upshifts" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="upshifts" CDS 900794..901258 /gene="yhbI" /locus_tag="BSU_08990" /old_locus_tag="BSU08990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20011599; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)induced by acid stress" /protein_id="NP_388780.1" /db_xref="EnsemblGenomes-Gn:BSU08990" /db_xref="EnsemblGenomes-Tr:CAB12727" /db_xref="GOA:O31592" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13003" /db_xref="UniProtKB/Swiss-Prot:O31592" /translation="MTESERALLTFEQLFDTSRAIYKKQKKILEIVLEPFDITVLQYL LMFKIHQSGSTPLSKLAMSLDLKPASVTRMTDILYKRQLMNRYDSPDDRRIVMIQLTE EGEELIEKAAVQYAKMGAGLYQKLDTSQLQYLRKLAGSLTKLAEGCSEKSGN*" /label="yhbI CDS" gene 900794..901258 /gene="yhbI" /locus_tag="BSU_08990" /old_locus_tag="BSU08990" /label="yhbI gene" promotor_-35 901083..901089 /Source="Nicolas_upshift_promotors" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 901104..901122 /Source="Nicolas_upshift_promotors" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 901117 /Source="Nicolas_upshifts" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 901267..901273 /Source="Nicolas_upshift_promotors" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 901287..901298 /Source="Nicolas_upshift_promotors" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 901293 /Source="Nicolas_upshifts" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="upshifts" CDS 901294..901959 /gene="yhbJ" /locus_tag="BSU_09000" /old_locus_tag="BSU09000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane fusion protein; putative exporter subunit (benzoate transcriptome)" /protein_id="NP_388781.1" /db_xref="EnsemblGenomes-Gn:BSU09000" /db_xref="EnsemblGenomes-Tr:CAB12728" /db_xref="GOA:O31593" /db_xref="InterPro:IPR011053" /db_xref="SubtiList:BG13004" /db_xref="UniProtKB/Swiss-Prot:O31593" /translation="MIEDETKGENKMNRGRLILTNIIGLIVVLAIIAGGAYYYYQSTN YVKTDEAKVAGDMAAITAPAAGKVSDWDLDEGKTVKKGDTVAKIKGEQTVDVKSIMDG TIVKNEVKNGQTVQAGTTIAQTIDMDNLYITANIKETDIADIEVGNSVDVVVDGDPDT TFDGTVEEIGYATNSTFDMLPSTNSSGNYTKVTQKVPVKISIKNPSDKVLPGMNASVK ISE*" /label="yhbJ CDS" gene 901294..901959 /gene="yhbJ" /locus_tag="BSU_09000" /old_locus_tag="BSU09000" /label="yhbJ gene" CDS 902000..903598 /gene="yhcA" /locus_tag="BSU_09010" /old_locus_tag="BSU09010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter (benzoate transcriptome)" /protein_id="NP_388782.1" /db_xref="EnsemblGenomes-Gn:BSU09010" /db_xref="EnsemblGenomes-Tr:CAB12729" /db_xref="GOA:P54585" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11579" /db_xref="UniProtKB/Swiss-Prot:P54585" /translation="MATGKEKNAKNPMSLLIVLMAGLFLAILNQTLLNVAMPHLMTEF GVSATTIQWLTTGYMLVNGVLIPLSAFLITRFGQRSLFLVAMFCFTLGTLVCGIAPNF STMLIGRLIQAVGGGILQPLVMTTILLIFPPESRGKGMGIFGLAMMFAPAVGPTLSGW IIEHYTWRIMFYGLVPIGAIVIIVAFFIFKNMVEPQKIKLDTLGAILSIVGFASLLYG VSEAGSDGWTDPIVLSTVIIGAIAIVAFVVQQLRHDDPMLDFRVFKYDIFSLSSVINI IITVALYTGMFLLPIYLQNLVGFTALQSGLLLLPGAIVMLIMSPISGILFDKFGPRPL AIIGLLVTVVTTYQYTQLTIDTPYTHIMLIYSIRAFGMSLLMMPVMTAGMNQLPARLN SHGTAMSNTLRQISGSIGTSLITTIYTNRTTFHYSQIADKTSTADPNFLHAFQNAVSN LMVNMNVSYDTAKTYVYSHIYKHASLDSNVMGINDAFMWATLFCVAGLILSIFLRDVR KDKLRKKKKEELSLLPAPKEAKES*" /label="yhcA CDS" gene 902000..903598 /gene="yhcA" /locus_tag="BSU_09010" /old_locus_tag="BSU09010" /label="yhcA gene" CDS 903621..904151 /gene="yhcB" /locus_tag="BSU_09020" /old_locus_tag="BSU09020" /EC_number="1.6.5.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15754243, 18041955, 17951395, 19665595, 20011599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH:quinone oxidoreductase associated to benzoate stress" /protein_id="NP_388783.1" /db_xref="EnsemblGenomes-Gn:BSU09020" /db_xref="EnsemblGenomes-Tr:CAB12730" /db_xref="GOA:P54586" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG11580" /db_xref="UniProtKB/Swiss-Prot:P54586" /translation="MKIYVVYDSEGEHTKVLAEAIAEGARENDAAEVFIDHVDQADIR KLKDMDAIIWGCPGHFGTISSGLKTWIDRLGYLWAEGELINKVGAVFCTTATTHGGLE MTMHNLITPMFHQGMIVVGLPGNVPENALYGSYYGAGVTCPVDSDELMSEEGIQLGRA LGRRVSQVTGNLTAGQ*" /label="yhcB CDS" gene 903621..904151 /gene="yhcB" /locus_tag="BSU_09020" /old_locus_tag="BSU09020" /label="yhcB gene" CDS 904164..904538 /gene="yhcC" /locus_tag="BSU_09030" /old_locus_tag="BSU09030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical membrane protein" /protein_id="NP_388784.1" /db_xref="EnsemblGenomes-Gn:BSU09030" /db_xref="EnsemblGenomes-Tr:CAB12731" /db_xref="GOA:P54587" /db_xref="SubtiList:BG11581" /db_xref="UniProtKB/Swiss-Prot:P54587" /translation="MAIIIAIIAAVIVIAALITFNVRNASPGPEKQEATDRIAPPEEE KNEAHYPAEARAAEHTPSVVKNDSPKEKRDTMGDDIYRQALQKFKHSDEVHAEEEVTE ESDKMQDRSYRDALLSMKNKKK*" /label="yhcC CDS" gene 904164..904538 /gene="yhcC" /locus_tag="BSU_09030" /old_locus_tag="BSU09030" /label="yhcC gene" downshifts 904527 /Source="Nicolas_upshifts" /id="D467" /incds=0 /nref=32 /ntot=145 /MaxReadThrough="1.78742" /MaxDrop="5.9171" /score="13.777309" /energy="-14.4" /TU="NA" /idTUdmin="U704" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 904538..904693 /gene="yhcD" /locus_tag="BSU_09040" /old_locus_tag="BSU09040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388785.1" /db_xref="EnsemblGenomes-Gn:BSU09040" /db_xref="EnsemblGenomes-Tr:CAB12732" /db_xref="SubtiList:BG11582" /db_xref="UniProtKB/Swiss-Prot:P54588" /translation="MKKANPFTHAGLPFLLFPSIMFLSNKSMEYVVFHLDLVYYVTHT PRIFSGR*" /label="yhcD CDS" gene 904538..904693 /gene="yhcD" /locus_tag="BSU_09040" /old_locus_tag="BSU09040" /label="yhcD gene" promotor_-35 904628..904634 /Source="Nicolas_upshift_promotors" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 904649..904668 /Source="Nicolas_upshift_promotors" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 904659 /Source="Nicolas_upshifts" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="upshifts" CDS 904698..905459 /gene="yhcE" /locus_tag="BSU_09050" /old_locus_tag="BSU09050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane orphan protein" /protein_id="NP_388786.1" /db_xref="EnsemblGenomes-Gn:BSU09050" /db_xref="EnsemblGenomes-Tr:CAB12733" /db_xref="GOA:P54589" /db_xref="SubtiList:BG11583" /db_xref="UniProtKB/Swiss-Prot:P54589" /translation="MNSFLGLLKKDIKLSRMWLLVWICGIIFLLGTGHIIASRTKEPL VIFGFFVAVAFFLLFLSPVFVFYHLRKEGKSQLWLYNPNGGLWLFSSKLAASLLYQFV IQLALTAYGIWMYHMLSVKNLLEHQVDITSTVALLNMYGLISSLDMSVTVIVFWTVFH SLRNWRGMRWAAMVLLVAMWLFFDEYIISPLVESQKHFWPVTVYCNFDFHFHNVWRLE LKPIHLSVLGFPIAIVITFLLLIMASKLLDRKVEV*" /label="yhcE CDS" gene 904698..905459 /gene="yhcE" /locus_tag="BSU_09050" /old_locus_tag="BSU09050" /label="yhcE gene" promotor_-10 complement(905011..905029) /Source="Nicolas_upshift_promotors" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(905025) /Source="Nicolas_upshifts" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(905045..905050) /Source="Nicolas_upshift_promotors" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 905462..905827 /gene="yhcF" /locus_tag="BSU_09060" /old_locus_tag="BSU09060" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family)" /protein_id="NP_388787.1" /db_xref="EnsemblGenomes-Gn:BSU09060" /db_xref="EnsemblGenomes-Tr:CAB12734" /db_xref="GOA:P54590" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11584" /db_xref="UniProtKB/Swiss-Prot:P54590" /translation="MDNQFQSSKPIYLQIADQIFYRLVRKELLPGDKLPSVREMAIQT KVNPNTIQRTYSEMERLGIVETRRGQGTFIAEKAEIVDELKDKLTREVLEGFVKQMKE LGLTKEEMLEGIKTFTEGG*" /label="yhcF CDS" gene 905462..905827 /gene="yhcF" /locus_tag="BSU_09060" /old_locus_tag="BSU09060" /label="yhcF gene" CDS 905829..906527 /gene="yhcG" /locus_tag="BSU_09070" /old_locus_tag="BSU09070" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15870467; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter ATP-binding protein" /protein_id="NP_388788.1" /db_xref="EnsemblGenomes-Gn:BSU09070" /db_xref="EnsemblGenomes-Tr:CAB12735" /db_xref="GOA:P54591" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11585" /db_xref="UniProtKB/Swiss-Prot:P54591" /translation="MEIKLEHVSKKYGRHTAVNDVSITLSSGRIYGLIGPNGSGKSTT LKMMAGLLFPTSGFVKVDEEQVTREMVRQTAYLTELDMFYPHFTVKDMVNFYQSQFPD FHTEQVYKLLNEMQLNPEKKIKKLSKGNRGRLKIVLALARRADVILLDEPFSGLDPMV RDSIVNSLVSYIDFEQQIVVIATHEIDEIETLLDEVIILANGEKVAQREVEDIREQEG MSVLQWFKSKMEVC*" /label="yhcG CDS" gene 905829..906527 /gene="yhcG" /locus_tag="BSU_09070" /old_locus_tag="BSU09070" /label="yhcG gene" CDS 906544..907461 /gene="yhcH" /locus_tag="BSU_09080" /old_locus_tag="BSU09080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7476193, 15870467; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388789.1" /db_xref="EnsemblGenomes-Gn:BSU09080" /db_xref="EnsemblGenomes-Tr:CAB12736" /db_xref="GOA:P54592" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11586" /db_xref="UniProtKB/Swiss-Prot:P54592" /translation="MKTVLELKNVTKNIRGRTIIDDLSFTIREGEVFGFLGPNGAGKT TTIRMMVGLMKLSKGDVLICGQSITKEYAKAIKHIGAIVENPELYKFLSGYKNLQQFA RMVKGVTKEKIDEVVELVGLTDRIHDKVKTYSLGMRQRLGLAQCLLHDPKVLILDEPT NGLDPAGIREIRDHLKKLTRERGMAVIVSSHLLSEMELMCDRIAILQKGKLIDIQNVK DENIDENDTYFFQVEQPSEAATVLNQYDLLSKTNGVEIKLAKEEVPAVIELLVMQQIR IYEVKVITKSLEDRFLEMTGETKEEVQHA*" /label="yhcH CDS" gene 906544..907461 /gene="yhcH" /locus_tag="BSU_09080" /old_locus_tag="BSU09080" /label="yhcH gene" CDS 907454..908395 /gene="yhcI" /locus_tag="BSU_09090" /old_locus_tag="BSU09090" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 15870467, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_388790.1" /db_xref="EnsemblGenomes-Gn:BSU09090" /db_xref="EnsemblGenomes-Tr:CAB12737" /db_xref="GOA:P54593" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11587" /db_xref="UniProtKB/Swiss-Prot:P54593" /translation="MLNLIYNEWLKIFSRAGTWVMIGILGLTMVGFAFLANHFSAGES NSHWKQELQAQNAELKKEIKEDPSLKDGYKETITLNDYRIEHNIPSDTGYTVWSYVTD SANFTILTGLFTIIIAAGIVANEFNWGTIKLLMIRPLSRFQILMSKYITVLLFGLLLL LILFIGSTLLGLIFFGTGGETAANIHLIYKDGHVIEQNMMGHLATTYLSESVSALMVA TMAFMLSAVFRNSSLAVGFSIFLLVAGTTATAFIAAKFDWAKYILFANVDLTQYVDGT PLIKGMTMTFSLVMLAIYFIIFLLLAFGIFMKRDIAN*" /label="yhcI CDS" gene 907454..908395 /gene="yhcI" /locus_tag="BSU_09090" /old_locus_tag="BSU09090" /label="yhcI gene" downshifts 908377 /Source="Nicolas_upshifts" /id="D468" /incds=0 /nref=43 /ntot=186 /MaxReadThrough="2.67567" /MaxDrop="4.46232" /score="20.0218504" /energy="-13.6" /TU="NA" /idTUdmin="U707" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(908487..908690) /gene="cspB" /locus_tag="BSU_09100" /old_locus_tag="BSU09100" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12493834, 16352840, 22128343, 25851716" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12493834, 16352840, 22128343, 25851716; Product type f: factor" /codon_start=1 /transl_table=11 /product="major cold-shock protein, RNA helicase co-factor, RNA co-chaperone" /protein_id="NP_388791.1" /db_xref="EnsemblGenomes-Gn:BSU09100" /db_xref="EnsemblGenomes-Tr:CAB12738" /db_xref="GOA:P32081" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="PDB:1CSP" /db_xref="PDB:1CSQ" /db_xref="PDB:1NMF" /db_xref="PDB:1NMG" /db_xref="PDB:2ES2" /db_xref="PDB:2F52" /db_xref="PDB:2I5L" /db_xref="PDB:2I5M" /db_xref="PDB:3PF4" /db_xref="PDB:3PF5" /db_xref="SubtiList:BG10824" /db_xref="UniProtKB/Swiss-Prot:P32081" /translation="MLEGKVKWFNSEKGFGFIEVEGQDDVFVHFSAIQGEGFKTLEEG QAVSFEIVEGNRGPQAANVTKEA*" /label="cspB CDS" gene complement(908487..908690) /gene="cspB" /locus_tag="BSU_09100" /old_locus_tag="BSU09100" /label="cspB gene" downshifts complement(908501) /Source="Nicolas_upshifts" /id="D469" /incds=0 /nref=169 /ntot=281 /MaxReadThrough="5.28215" /MaxDrop="9.14889" /score="33.2405587" /energy="-13.1" /TU="U710" /idTUdmin="U710" /TUdmin="-48" /isTUend="FALSE" /label="downshifts" S_feature complement(908691..908818) /Source="Nicolas_S_feature" /locus_tag="new_984466_984593_c" /HighExp="BC, C90, GM 15, BI, T-1.10H, UNK1, S1, Sw, nit, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S315" misc_feature 908778..908789 /Source="Nicolas_upshift_promotors" /id="U709" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.618381618381618" /psig="0.098901098901099" /xcortree=713 /SigmaFactorBS="ttgctcttaacaaactttcaagacgaaaactcttacaaaact tTCTTCTTAAAGAtagttcgaacaaaaataattacctttactctaccagtaatcttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 908795 /Source="Nicolas_upshifts" /id="U709" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.618381618381618" /psig="0.098901098901099" /xcortree=713 /SigmaFactorBS="ttgctcttaacaaactttcaagacgaaaactcttacaaaact tTCTTCTTAAAGAtagttcgaacaaaaataattacctttactctaccagtaatcttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(908807..908826) /Source="Nicolas_upshift_promotors" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(908818) /Source="Nicolas_upshifts" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(908820..909958) /Source="Nicolas_S_feature" /locus_tag="new_984595_985733_c" /HighExp="C30, G180, G150, Oxctl, G135, Paraq, HPh, LPh, dia0, Lbexp" /AntisenseName="yhcJ" /AntisenseCor="0.25433958616302499" /AntisenseRegPval="-4.5999999999999996" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S316" promotor_-35 complement(908840..908845) /Source="Nicolas_upshift_promotors" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 908985..908992 /Source="Nicolas_upshift_promotors" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 909007..909025 /Source="Nicolas_upshift_promotors" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 909014 /Source="Nicolas_upshifts" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="upshifts" S_feature 909015..909125 /Source="Nicolas_S_feature" /locus_tag="new_984790_984900" /HighExp="Diami, dia15, dia5, H2O2, Salt, C90, Paraq, UNK1, T-4.40H, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S317" CDS 909126..909956 /gene="yhcJ" /locus_tag="BSU_09110" /old_locus_tag="BSU09110" /function="7: Transport and binding proteins" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative ABC transporter (binding lipoprotein)" /protein_id="NP_388792.2" /db_xref="EnsemblGenomes-Gn:BSU09110" /db_xref="EnsemblGenomes-Tr:CAB12739" /db_xref="GOA:P54594" /db_xref="InterPro:IPR004872" /db_xref="SubtiList:BG11588" /db_xref="UniProtKB/Swiss-Prot:P54594" /translation="MKKWLICSFVLVLLVSFTACSPSAEHESIKIGIAESDGAIWNYI AQKAEEAGLDIQLIPFSDYAESDIALANKEIDANAFQTISYFQSFTEKYKLNLAPLGT TYITPMGIYSKRYERIRDISRGAVVSVPDKAFDFGRALTVLQEAGLLTLKNGFNGTGS VDMIKDNPRHLKLKAVRQQDAVSGADVFVMKPSEAKKAGLNPKKHTLKSGGLMSEEEM NLIVVRAEDQDREALQTILELYQADDTAAFIEKEYQGDLVPAFLPLKRLSDWKNEFEH *" /label="yhcJ CDS" gene 909126..909956 /gene="yhcJ" /locus_tag="BSU_09110" /old_locus_tag="BSU09110" /label="yhcJ gene" downshifts 909915 /Source="Nicolas_upshifts" /id="D470" /incds=0 /nref=38 /ntot=203 /MaxReadThrough="2.83059" /MaxDrop="3.90173" /score="-4.94928928" /energy="-7.3" /TU="NA" /idTUdmin="U711" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(909959..911038) /gene="dgcK" /locus_tag="BSU_09120" /old_locus_tag="BSU09120" /EC_number="2.7.7.65" /function="16.3: Control" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:23893111" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="NP_388793.1" /db_xref="EnsemblGenomes-Gn:BSU09120" /db_xref="EnsemblGenomes-Tr:CAB12740" /db_xref="GOA:P54595" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR011620" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG11589" /db_xref="UniProtKB/Swiss-Prot:P54595" /translation="MLKELFVNLTILITFNYLFTHLFKERLVHKKDSISFQAVKGLAC GLLGVILMVFGFTYQHSIIDLRNIPIMIAALYGGWVSTATALAMITAGRLLITMNTSA LYSVIIICIAAIPSLIVSRRKKVQLKHAFYLLIITNSLISFSFYFLIDLHSYELHLYF WIISIAGGMLSLYIIDHETNAHLLFKQYKFQAHFDFLTGVYNRRKFEETTKALYQQAA DTPHFQFALIYMDIDHFKTINDQYGHHEGDQVLKELGLRLKQTIRNTDPAARIGGEEF AVLLPNCSLDKAARIAERIRSTVSDAPIVLTNGDELSVTISLGAAHYPNNTEQPGSLP ILADQMLYKAKETGRNRVCFSEKKE*" /label="dgcK CDS" gene complement(909959..911038) /gene="dgcK" /locus_tag="BSU_09120" /old_locus_tag="BSU09120" /label="dgcK gene" promotor_-10 complement(911048..911067) /Source="Nicolas_upshift_promotors" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="promotor_-10" upshifts complement(911069) /Source="Nicolas_upshifts" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="upshifts" promotor_-35 complement(911083..911087) /Source="Nicolas_upshift_promotors" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="promotor_-35" promotor_-35 911145..911152 /Source="Nicolas_upshift_promotors" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 911166..911185 /Source="Nicolas_upshift_promotors" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 911172 /Source="Nicolas_upshifts" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="upshifts" CDS 911211..912602 /gene="tcyP" /locus_tag="BSU_09130" /old_locus_tag="BSU09130" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12193636, 15262924, 15849754, 16513748, 16850406, 19508281" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193636, 15262924, 15849754, 16513748, 16850406, 19508281; Product type t : transporter" /codon_start=1 /transl_table=11 /product="(sodium)-cystine symporter" /protein_id="NP_388794.1" /db_xref="EnsemblGenomes-Gn:BSU09130" /db_xref="EnsemblGenomes-Tr:CAB12741" /db_xref="GOA:P54596" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG11590" /db_xref="UniProtKB/Swiss-Prot:P54596" /translation="METLLVVLHVFILFLLILGLFVMQKKHVSFSKRVFTALGLGIVF GFALQLIYGPTSNIVIQTADWFNIAGGGYVKLLQMVVMPLVFISILGAFTKLKLTKNL GKISGLIIGILVATTAVAAAVGIASALSFDLQAIQVDQGSTELSRGQELQQKSEDMTA KTLPQQIVELLPGNPFLDFTGARPTSTIAVVIFAAFLGVAFLGVKHKQPEQAETFKKL VDAVYAIVMRVVTLILRLTPYGVLAIMTKTIATSDLDSILKLGMFVIASYAALITMFI IHLLLLTFSGLNPVIYLKKAVPVLVFAFTSRSSAGALPLNIKTQRSMGVPEGIANFAG SFGLSIGQNGCAGIYPAMLAMMIAPTVGQNPFDPVFIITVIAVVAISSFGVAGVGGGA TFAALLVLSSLNMPVALAGLLISIEPLIDMGRTALNVSGSMTSGLITSKVTKEIDQGA FHDQSRVIEAEEA*" /label="tcyP CDS" gene 911211..912602 /gene="tcyP" /locus_tag="BSU_09130" /old_locus_tag="BSU09130" /label="tcyP gene" S_feature complement(912238..912641) /Source="Nicolas_S_feature" /locus_tag="new_988013_988416_c" /HighExp="S8, S6, Etha, S5, S7, S4, ferm, nit, Salt, S3" /AntisenseName="tcyP" /AntisenseCor="-0.40132140065468203" /AntisenseRegPval="-11.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S318" downshifts 912581 /Source="Nicolas_upshifts" /id="D471" /incds=0 /nref=58 /ntot=164 /MaxReadThrough="2.37899" /MaxDrop="5.34563" /score="19.9118074" /energy="-12.8" /TU="NA" /idTUdmin="U713" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(912642..913097) /gene="yhcM" /locus_tag="BSU_09140" /old_locus_tag="BSU09140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21625606" /codon_start=1 /transl_table=11 /product="expressed protein of unknown function" /protein_id="NP_388795.1" /db_xref="EnsemblGenomes-Gn:BSU09140" /db_xref="EnsemblGenomes-Tr:CAB12742" /db_xref="SubtiList:BG11591" /db_xref="UniProtKB/Swiss-Prot:P54597" /translation="MLFNQRRGISPAALIIGSTMLITALSPQIRQRISGFITGQMNRR NSENNTFDASNVGNMVKQAFSGSSGSSGDNQDRSQHQSQRQNGRQHQHAGQQQPQHQH TQSQTRQTETAAKKRQPHYAEPIHFEQNAMNVMDDNTMMEMLEDLEPGR*" /label="yhcM CDS" gene complement(912642..913097) /gene="yhcM" /locus_tag="BSU_09140" /old_locus_tag="BSU09140" /label="yhcM gene" promotor_-10 complement(913112..913130) /Source="Nicolas_upshift_promotors" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(913140) /Source="Nicolas_upshifts" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(913145..913151) /Source="Nicolas_upshift_promotors" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 913189..913195 /Source="Nicolas_upshift_promotors" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 913209..913220 /Source="Nicolas_upshift_promotors" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 913213 /Source="Nicolas_upshifts" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="upshifts" CDS 913247..913816 /gene="yhcN" /locus_tag="BSU_09150" /old_locus_tag="BSU09150" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9611260, 28333204; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative germination lipoprotein" /protein_id="NP_388796.2" /db_xref="EnsemblGenomes-Gn:BSU09150" /db_xref="EnsemblGenomes-Tr:CAB12743" /db_xref="GOA:P54598" /db_xref="InterPro:IPR014247" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG11592" /db_xref="UniProtKB/Swiss-Prot:P54598" /translation="MFGKKQVLASVLLIPLLMTGCGVADQGEGRRDNNDVRNVNYRNP ANDDMRNVNNRDNVDNNVNDNVNNNRVNDDNNNDRKLEVADEAADKVTDLKEVKHADI IVAGNQAYVAVVLTNGNKGAVENNLKKKIAKKVRSTDKNIDNVYVSANPDFVERMQGY GKRIQNGDPIAGLFDEFTQTVQRVFPNAE*" /label="yhcN CDS" gene 913247..913816 /gene="yhcN" /locus_tag="BSU_09150" /old_locus_tag="BSU09150" /label="yhcN gene" promotor_-35 913443..913449 /Source="Nicolas_upshift_promotors" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 913460 /Source="Nicolas_upshifts" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 913463..913474 /Source="Nicolas_upshift_promotors" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 913791 /Source="Nicolas_upshifts" /id="D472" /incds=0 /nref=26 /ntot=183 /MaxReadThrough="1.84697" /MaxDrop="7.80159" /score="33.0647397" /energy="-12.9" /TU="NA" /idTUdmin="U715" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" promotor_-35 913859..913868 /Source="Nicolas_upshift_promotors" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 913882..913901 /Source="Nicolas_upshift_promotors" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 913892 /Source="Nicolas_upshifts" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="upshifts" CDS 913937..914905 /gene="yhcO" /locus_tag="BSU_09165" /old_locus_tag="BSU09165" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="putative exported protein (sporulation germination island)" /protein_id="NP_388797.2" /db_xref="EnsemblGenomes-Gn:BSU09165" /db_xref="EnsemblGenomes-Tr:CAB12744" /db_xref="SubtiList:BG11593" /db_xref="UniProtKB/Swiss-Prot:P54599" /translation="MRDGIGKRAASALFLCGVLVMLAVSSAIVSSAMYILSFPGQASG ITKEQVTKHMKKESFKQADIYYTSKEKSLLPLTKETLEYAVSINQIMIGYSNQKPIDI IFFPNEKQMEAYSGLLDVVGFYSEREQLIGLLPEEKKKLLEGDEVAVYLYQRLLIHEY SHHAFHQKLKELETDPDEFPLWFHEGLSEWIANYELLIDPITFSVVPFDRLQTDRDWQ EARAEYDTDVYLQSFYMIDELTDKYGKDIISEMIKETAKKGDFEKGFKSATKESLDQF EKDFKKKFEKNSAALDSIYPMPLLLVKSLLTHSALCRRHLSLGRGE*" /label="yhcO CDS" gene 913937..914905 /gene="yhcO" /locus_tag="BSU_09165" /old_locus_tag="BSU09165" /label="yhcO gene" downshifts 914781 /Source="Nicolas_upshifts" /id="D473" /incds=1 /nref=28 /ntot=62 /MaxReadThrough="1.51621" /MaxDrop="5.75619" /score="6.21571271" /energy="-16.1" /TU="NA" /idTUdmin="U717" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(914837..915490) /gene="yhcQ" /locus_tag="BSU_09180" /old_locus_tag="BSU09180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_388799.1" /db_xref="EnsemblGenomes-Gn:BSU09180" /db_xref="EnsemblGenomes-Tr:CAB12746" /db_xref="GOA:P54601" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG11595" /db_xref="UniProtKB/Swiss-Prot:P54601" /translation="MDQFNQQQQSQMNKGIPGKPHKNHGGHEMFDMHEVLSGTLTVLD QFMMLRQFCKDQELLNILDRQHQFITSQYNITAECFKTGSEPSQKTATYMMKEDNQTV YGMQPSQPKKPVQSMNDIDDSIISRQMLCAIKAQASMLTMASLEMTNPAVRRVLSAQI QEYVEMAFEIFLYQNKHGYYQVPQLDAQDMEQLRNSFAPAQGQMPPTQGGMGQQGLH* " /label="yhcQ CDS" gene complement(914837..915490) /gene="yhcQ" /locus_tag="BSU_09180" /old_locus_tag="BSU09180" /label="yhcQ gene" downshifts complement(914854) /Source="Nicolas_upshifts" /id="D474" /incds=0 /nref=15 /ntot=57 /MaxReadThrough="4.13099" /MaxDrop="4.95733" /score="8.67086892" /energy="-12.9" /TU="U718" /idTUdmin="U718" /TUdmin="-546" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(915521..915532) /Source="Nicolas_upshift_promotors" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(915523) /Source="Nicolas_upshifts" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(915547..915553) /Source="Nicolas_upshift_promotors" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 915562..915570 /Source="Nicolas_upshift_promotors" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 915573..919226 /gene="mncR" /locus_tag="BSU_09190" /old_locus_tag="BSU09190" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15292138, 21800427, 22020651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15292138, 21800427, 22020651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="non specific extracellular Ca2+-dependent endonuclease cleaving RNA and DNA" /protein_id="NP_388800.1" /db_xref="EnsemblGenomes-Gn:BSU09190" /db_xref="EnsemblGenomes-Tr:CAB12747" /db_xref="GOA:P54602" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006146" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR016071" /db_xref="InterPro:IPR019948" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR035437" /db_xref="InterPro:IPR035451" /db_xref="InterPro:IPR036907" /db_xref="SubtiList:BG11596" /db_xref="UniProtKB/Swiss-Prot:P54602" /translation="MLSVEMISRQNRCHYVYKGGNMMRRILHIVLITALMFLNVMYTF EAVKAAEPQQPISIEKAIQQKEGQALVEGYAVGQAVSPQHYKLTSPFSNDYNVALADR KNKTSPEHILPVQIPSAFRSQFGLQTNPLLLGKKITVQGKLENYFNTTGLKNVQSMNV TDDTKTPPAEQQVTINEARGRLNEEVTIKGIITADQNAIGGGKLSTFLQDETGGINIY SPSPEQFPELKEGMDVTVTGKITSYQGLKEIVPNSSGIKINQSNQSLPAPKHLTINEL INGSLGDQYEGRLVKLTAFVSSIPSSPAGGGYNVTMIDDDHHAMTLRVMNETGVINEL DEGKWYEFTGVLSRYQTFQLLPRKSADLKLLEEQPAPPSAEGEYEGIVDRVVDGDTIH LKSPVLGTTKIRFVNVDAPETYHTPKNDADENQLRFGKKASDYLKTVLSPGDKITVKV GSEAKDSYGRLLGQVITESGSNVNLELVKNGYAPTYFIWPVDNEEDYQQFQAAVAAAK KDQKGIWNENDPLMEMPFEFRAREQGKGLTRYVGDSSNKTYVQPADWKKIAVENRIFF ASASEAESAGYKKRQTAPQEHVPLRILSMNDLHGKIDQQYELDLDGNGTVDGTFGRMD YAAAYLKEKKAEKKNSLIVHAGDMIGGSSPVSSLLQDEPTVELMEDIGFDVGTVGNHE FDEGTDELLRILNGGDHPKGTSGYDGQNFPLVCANCKMKSTGEPFLPAYDIINVEGVP VAFIGVVTQSAAGMVMPEGIKNIEFTDEATAVNKAAEELKKKGVKAIAVLAHMSAEQN GNAITGESADLANKTDSEIDVIFAAHNHQVVNGEVNGKLIVQAFEYGKAIGVVDVEID KTTKDIVKKSAEIVYVDQSKIEPDVSASAILKKYETIAEPIISEVVGEAAVDMEGGYS NDGDTPLGNLIADGMRAAMKTDFALMNGGGIREALKKGPITWGDLYNIQPFGNVLTKL EIKGKDLREIINAQISPVFGPDYSISGFTYTWDKETGKAVDMKMADGTEIQPDATYTL TVNNFMATATGAKYQPIGLLGKNPVTGPEDLEATVEYVKSFDEPIAYTKEGRIKLAEA SDIEDPVTEDPITEEPGDDPGTEDPIKEDPRPGEDLPDIKETPGTAPVHQLPPSAISR FNEIPINNTKTADTANSISTLPLQTETAESGSDHQLPDTSAGYYNFMVIGAAVTLSGT YLYVRRKRSASRT*" /label="mncR CDS" gene 915573..919226 /gene="mncR" /locus_tag="BSU_09190" /old_locus_tag="BSU09190" /label="mncR gene" promotor_-10 915581..915599 /Source="Nicolas_upshift_promotors" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 915596 /Source="Nicolas_upshifts" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="upshifts" CDS 919223..919819 /gene="srtA" /locus_tag="BSU_09200" /old_locus_tag="BSU09200" /EC_number="3.4.22.70" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12823805, 21800427, 22020651, 25038633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12823805, 21800427, 22020651, 25038633; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sortase A" /protein_id="NP_388801.1" /db_xref="EnsemblGenomes-Gn:BSU09200" /db_xref="EnsemblGenomes-Tr:CAB12748" /db_xref="GOA:P54603" /db_xref="InterPro:IPR005754" /db_xref="InterPro:IPR023365" /db_xref="SubtiList:BG11597" /db_xref="UniProtKB/Swiss-Prot:P54603" /translation="MKKVIPLFIIAAGLVIAGYGGFKLIDTNTKTEQTLKEAKLAAKK PQEASGTKNSTDQAKNKASFKPETGQASGILEIPKINAELPIVEGTDADDLEKGVGHY KDSYYPDENGQIVLSGHRDTVFRRTGELEKGDQLRLLLSYGEFTYEIVKTKIVDKDDT SIITLQHEKEELILTTCYPFSYVGNAPKRYIIYGKRVT*" /label="srtA CDS" gene 919223..919819 /gene="srtA" /locus_tag="BSU_09200" /old_locus_tag="BSU09200" /label="srtA gene" downshifts 919798 /Source="Nicolas_upshifts" /id="D475" /incds=0 /nref=142 /ntot=248 /MaxReadThrough="0.9984" /MaxDrop="5.92245" /score="-4.06268332" /energy="-8.8" /TU="NA" /idTUdmin="U719" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(919849..920757) /gene="yhcT" /locus_tag="BSU_09210" /old_locus_tag="BSU09210" /EC_number="5.4.99.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9814761, 15044829; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA pseudouridine synthase" /protein_id="NP_388802.2" /db_xref="EnsemblGenomes-Gn:BSU09210" /db_xref="EnsemblGenomes-Tr:CAB12749" /db_xref="GOA:P54604" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11598" /db_xref="UniProtKB/Swiss-Prot:P54604" /translation="MNQKGRGLEILINEKQDGQWLFSVLKTALKASKPVIQDWMSHQQ IKVNHESVLNNMIVKKGDRVFIDLQESEASSVIPEYGELDILFEDNHMLIINKPAGIA THPNEDGQTGTLANLIAYHYQINGETCKVRHVHRLDQDTSGAIVFAKHRLAHAILDQQ LEKKTLKRTYTAIAEGKLRTKKGTINSPIGRDRSHPTRRRVSPGGQTAVTHFKVMASN AKERLSLVELELETGRTHQIRVHLASLGHPLTGDSLYGGGSKLLNRQALHANKVQAVH PITDELIVAEAPFPADMKNLCRTYFS*" /label="yhcT CDS" gene complement(919849..920757) /gene="yhcT" /locus_tag="BSU_09210" /old_locus_tag="BSU09210" /label="yhcT gene" promotor_-35 920813..920821 /Source="Nicolas_upshift_promotors" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(920814..920825) /Source="Nicolas_upshift_promotors" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(920820) /Source="Nicolas_upshifts" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(920822..921308) /Source="Nicolas_S_feature" /locus_tag="new_996597_997083_c" /HighExp="S8, dia15, Diami, H2O2, G180, G150, dia5, Paraq, Oxctl, S7" /AntisenseName="yhcU" /AntisenseCor="0.69394173601478304" /AntisenseRegPval="-39.200000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.958" /TUlongSig="NA" /TUlongPSig="NA" /label="S319" upshifts 920832 /Source="Nicolas_upshifts" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 920835..920854 /Source="Nicolas_upshift_promotors" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(920839..920845) /Source="Nicolas_upshift_promotors" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="promotor_-35" CDS 920868..921263 /gene="yhcU" /locus_tag="BSU_09220" /old_locus_tag="BSU09220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388803.2" /db_xref="EnsemblGenomes-Gn:BSU09220" /db_xref="EnsemblGenomes-Tr:CAB12750" /db_xref="InterPro:IPR020355" /db_xref="SubtiList:BG11599" /db_xref="UniProtKB/Swiss-Prot:P54605" /translation="MARKVIDVRIVNAATAEQESFIKELSMELIHDVFPLYFSELDIQ RFKKKGVLSLNNHYYQGTLKEAFQIMACLQMIHIILTKPSPHSDLSDQAIFEKNSKML NDFGIYFPFAFSDFQKKTNKAFFGQRRLI*" /label="yhcU CDS" gene 920868..921263 /gene="yhcU" /locus_tag="BSU_09220" /old_locus_tag="BSU09220" /label="yhcU gene" misc_feature complement(921294..921313) /Source="Nicolas_upshift_promotors" /id="U722" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.709290709290709" /psig="0.958041958041958" /xcortree=1819 /SigmaFactorBS="cagacacgagccgtttaaaaagggagttagaggaaaggtttt atgatatgatttcTCTGATACAAAAAGAGCTTTtctaaaaatagaaaagcccttgccg c" /listShort="S319, yhcT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(921308) /Source="Nicolas_upshifts" /id="U722" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.709290709290709" /psig="0.958041958041958" /xcortree=1819 /SigmaFactorBS="cagacacgagccgtttaaaaagggagttagaggaaaggtttt atgatatgatttcTCTGATACAAAAAGAGCTTTtctaaaaatagaaaagcccttgccg c" /listShort="S319, yhcT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 921348..921354 /Source="Nicolas_upshift_promotors" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 921363 /Source="Nicolas_upshifts" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 921368..921379 /Source="Nicolas_upshift_promotors" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(921378..921392) /Source="Nicolas_upshift_promotors" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(921392) /Source="Nicolas_upshifts" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(921400..921404) /Source="Nicolas_upshift_promotors" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 921400..921822 /gene="yhcV" /locus_tag="BSU_09230" /old_locus_tag="BSU09230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative CBS containing enzyme (sporulation-/ germination-related)" /protein_id="NP_388804.1" /db_xref="EnsemblGenomes-Gn:BSU09230" /db_xref="EnsemblGenomes-Tr:CAB12751" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG11600" /db_xref="UniProtKB/Swiss-Prot:P54606" /translation="MSSVKDTMTTQVATVSPNQTIQEAASLMKQHNVGAIPVVEQGVL KGMLTDRDIALRTTAQGRDGQTPVSEVMSTELVSGNPNMSLEDASQLMAQHQIRRLPI VDQNNLVGIVALGDLAVNQMSNESAGSALTNISHQNIH*" /label="yhcV CDS" gene 921400..921822 /gene="yhcV" /locus_tag="BSU_09230" /old_locus_tag="BSU09230" /label="yhcV gene" promotor_no_box complement(921726..921826) /Source="Nicolas_upshift_promotors" /id="U725" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.014985014985015" /xcortree=1493 /SigmaFactorBS="cttattaatgaatgttttggtgagaaatgtttgtcagcgctg atcccgcagactcgttcgacatctgattgactgccaggtctccaagcgcaacgatccc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(921766) /Source="Nicolas_upshifts" /id="U725" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.014985014985015" /xcortree=1493 /SigmaFactorBS="cttattaatgaatgttttggtgagaaatgtttgtcagcgctg atcccgcagactcgttcgacatctgattgactgccaggtctccaagcgcaacgatccc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 921800 /Source="Nicolas_upshifts" /id="D476" /incds=0 /nref=50 /ntot=61 /MaxReadThrough="2.62549" /MaxDrop="7.03747" /score="-2.59023198" /energy="-12.1" /TU="NA" /idTUdmin="U723" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(921832) /Source="Nicolas_upshifts" /id="D477" /incds=0 /nref=2 /ntot=10 /MaxReadThrough="0.0992700000000006" /MaxDrop="3.96142" /score="-9.32793172" /energy="-9.1" /TU="NA" /idTUdmin="U724" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" promotor_-35 921872..921879 /Source="Nicolas_upshift_promotors" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 921893..921912 /Source="Nicolas_upshift_promotors" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 921901 /Source="Nicolas_upshifts" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="upshifts" CDS 921949..922611 /gene="glpW" /locus_tag="BSU_09240" /old_locus_tag="BSU09240" /EC_number="3.1.3.18" /EC_number="3.1.3.68" /EC_number="3.1.3.-" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16990279, 22353596; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphoglycolate phosphatase / glycerol-3-phosphate phosphatase / 2-deoxyglucose-6-phosphatase" /protein_id="NP_388805.1" /db_xref="EnsemblGenomes-Gn:BSU09240" /db_xref="EnsemblGenomes-Tr:CAB12752" /db_xref="GOA:P54607" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11601" /db_xref="UniProtKB/Swiss-Prot:P54607" /translation="MIKALIFDFDGLILDTETHEYEVLQEIFEEHGSVLPLSVWGKVI GTAAGFRPFEYLEEQIGKKLNHEELTQLRRERFAKRMESEKARPGVEAYLNAAKDLGL KIGLASSSDYKWVSGHLKQIGLFDDFEVIQTADDVEEVKPNPELYLLAAKNLGVSPAE CLAFEDSVNGSIAAKRAGMKCVIVPNKVTGTLMFEDYDHRLESMAEMELALLLDHLNS QN*" /label="glpW CDS" gene 921949..922611 /gene="glpW" /locus_tag="BSU_09240" /old_locus_tag="BSU09240" /label="glpW gene" CDS 922627..924168 /gene="yhcX" /locus_tag="BSU_09250" /old_locus_tag="BSU09250" /EC_number="3.5.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26337367, 26808445, 17555270; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidohydrolase" /protein_id="NP_388806.2" /db_xref="EnsemblGenomes-Gn:BSU09250" /db_xref="EnsemblGenomes-Tr:CAB12753" /db_xref="GOA:P54608" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR001110" /db_xref="InterPro:IPR003010" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR036526" /db_xref="SubtiList:BG11602" /db_xref="UniProtKB/Swiss-Prot:P54608" /translation="MSEKLDLTRFEKKMVIRNIEEKDIDKIIDLQKDCFPGMEPWKRE HLISHLEHFPEGQFCAEFEGEIIGSCSSLLINFDEYDDRHTWQDITDDGYITNHNPDG LNMYGIEVMVHPKYRRMKIGHRLYEARKDLARRLNLKSIIIGGRIPNYHKYAEEMTAR EYVEQVTRHQIYDPVLSFQLMNGFTLMRINPNYLPDDTASIKYATLMEWNNVDYLPQQ TKRYYKSAFPVRICVIQYEMKKIYSFEEFANQVEYYVDVASDARSDFAVFPEIFTTQL MSFLEERSPSLAVQRITEYTEDYISLFTDLAVKYNVNIIGGSHFVEEEGKIYNIAYLF RRDGTIEKQYKLHITPNERKWWGISAGDQVRVFDTDCGKIAIQICYDIEFPELARIAA DKGAKIIFTPFCTEDRQGYLRVRYCSQARAVENQIYTVISGTVGNLPQTENMDIQYAQ SGIFAPSDFEFARDGIVGETNPNIEMVVIGDVDLEILRRQRQNGTVRQLKDRRRDIYH IQYKK*" /label="yhcX CDS" gene 922627..924168 /gene="yhcX" /locus_tag="BSU_09250" /old_locus_tag="BSU09250" /label="yhcX gene" downshifts 924151 /Source="Nicolas_upshifts" /id="D478" /incds=0 /nref=57 /ntot=238 /MaxReadThrough="4.24486" /MaxDrop="5.06754" /score="24.7413026" /energy="-10.5" /TU="U726" /idTUdmin="U726" /TUdmin="-224" /isTUend="FALSE" /label="downshifts" CDS 924252..924443 /gene="yhzG" /locus_tag="BSU_09259" /old_locus_tag="BSU09259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52585.1" /translation="MYSGCALWSFCIFAISYIIQKTARLHIAIAMAVQVVSSATFIST MLSIVTLPVLLWKLHPLSS*" /label="yhzG CDS" gene 924252..924443 /gene="yhzG" /locus_tag="BSU_09259" /old_locus_tag="BSU09259" /pseudo /label="yhzG gene" promotor_-35 924474..924481 /Source="Nicolas_upshift_promotors" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="promotor_-35" promotor_-10 924496..924515 /Source="Nicolas_upshift_promotors" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="promotor_-10" S_feature 924507..924588 /Source="Nicolas_S_feature" /locus_tag="new_1000282_1000363" /HighExp="M40t90, M0t90, T0.30H, LBGstat, BC, Lbstat, M9-stat, Lbtran, T1.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S320" upshifts 924507 /Source="Nicolas_upshifts" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="upshifts" CDS 924589..925941 /gene="yhxA" /locus_tag="BSU_09260" /old_locus_tag="BSU09260" /EC_number="2.6.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11082195, 23610425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminotransferase" /protein_id="NP_388807.2" /db_xref="EnsemblGenomes-Gn:BSU09260" /db_xref="EnsemblGenomes-Tr:CAB12754" /db_xref="GOA:P33189" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10184" /db_xref="UniProtKB/Swiss-Prot:P33189" /translation="MEMMGMENIQQNQGLKQKDEQFVWHAMKGAHQADSLIAQKAEGA WVTDTDGRRYLDAMSGLWCVNIGYGRKELAEAAYEQLKELPYYPLTQSHAPAIQLAEK LNEWLGGDYVIFFSNSGSEANETAFKIARQYHLQNGDHSRYKFISRYRAYHGNTLGAL SATGQAQRKYKYEPLSQGFLHAAPPDIYRNPDDADTLESANEIDRIMTWELSETIAGV IMEPIITGGGILMPPDGYMKKVEDICRRHGALLICDEVICGFGRTGEPFGFMHYGVKP DIITMAKGITSAYLPLSATAVKRDIFEAYQGEAPYDRFRHVNTFGGSPAACALALKNL QIMEDEQLIQRSRDLGAKLLGELQALREHPAVGDVRGKGLLIGIELVKDKLTKEPADA AKVNQVVAACKEKGLIIGKNGDTVAGYNNVIQLAPPFCLTEEDLSFIVKTVKESFQTI *" /label="yhxA CDS" gene 924589..925941 /gene="yhxA" /locus_tag="BSU_09260" /old_locus_tag="BSU09260" /label="yhxA gene" CDS 925969..926547 /gene="glpP" /locus_tag="BSU_09270" /old_locus_tag="BSU09270" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11929549, 23610425, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11929549, 23610425, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate responding transcriptionantiterminator" /protein_id="NP_388808.1" /db_xref="EnsemblGenomes-Gn:BSU09270" /db_xref="EnsemblGenomes-Tr:CAB12755" /db_xref="GOA:P30300" /db_xref="InterPro:IPR006699" /db_xref="InterPro:IPR035928" /db_xref="SubtiList:BG10185" /db_xref="UniProtKB/Swiss-Prot:P30300" /translation="MMSFHNQPILPAIRNMKQFDEFLNSSFSYGVILDIHLGQLKGVI KEAQKHGKNMMVHVDLIQGIKHDEYGAEFICQDIKPAGIISTRSNVIAKAKQKKIYAI QRLFLLDTSAMEKSMEFIGKHKPDFIEVLPGIVPSLIQEIKEKTGIPIFAGGFIRTEE DVEQALKAGAVAVTTSNTKLWKKYENFLTESD*" /label="glpP CDS" gene 925969..926547 /gene="glpP" /locus_tag="BSU_09270" /old_locus_tag="BSU09270" /label="glpP gene" promotor_-35 926542..926549 /Source="Nicolas_upshift_promotors" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 926564..926583 /Source="Nicolas_upshift_promotors" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 926575 /Source="Nicolas_upshifts" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="upshifts" downshifts 926590 /Source="Nicolas_upshifts" /id="D479" /incds=0 /nref=3 /ntot=39 /MaxReadThrough="8.20986" /MaxDrop="2.99328" /score="6.07464219" /energy="-10" /TU="U727,U728" /idTUdmin="U726" /TUdmin=2215 /isTUend="FALSE" /label="downshifts" S_feature 926635..926725 /Source="Nicolas_S_feature" /locus_tag="new_1002410_1002500" /HighExp="Diami, T0.30H, G150, Oxctl, Gly, Paraq, dia5, BC, B60, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S321" CDS 926726..927550 /gene="glpF" /locus_tag="BSU_09280" /old_locus_tag="BSU09280" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11929549, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11929549, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycerol permease" /protein_id="NP_388809.1" /db_xref="EnsemblGenomes-Gn:BSU09280" /db_xref="EnsemblGenomes-Tr:CAB12756" /db_xref="GOA:P18156" /db_xref="InterPro:IPR000425" /db_xref="InterPro:IPR022357" /db_xref="InterPro:IPR023271" /db_xref="SubtiList:BG10186" /db_xref="UniProtKB/Swiss-Prot:P18156" /translation="MTAFWGEVIGTMLLIIFGAGVCAGVNLKKSLSFQSGWIVVVFGW GLGVAMAAYAVGGISGAHLNPALTIALAFVGDFPWKEVPVYIAAQMIGAIIGAVIIYL HYLPHWKSTDDPAAKLGVFSTGPSIPHTFANVLSEVIGTFVLVLGILAIGANQFTEGL NPLIVGFLIVAIGISLGGTTGYAINPARDLGPRIAHAFLPIPGKGSSNWKYAWVPVVG PILGGSFGGVFYNAAFKGHITSSFWIVSVILVVVLLGLYVYTKSHSAKTLSNSKYI*" /label="glpF CDS" gene 926726..927550 /gene="glpF" /locus_tag="BSU_09280" /old_locus_tag="BSU09280" /label="glpF gene" CDS 927569..929059 /gene="glpK" /locus_tag="BSU_09290" /old_locus_tag="BSU09290" /EC_number="2.7.1.30" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9972264, 10920256, 11929549, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycerol kinase (sn-glycerol-3-phosphate generating)" /protein_id="NP_388810.2" /db_xref="EnsemblGenomes-Gn:BSU09290" /db_xref="EnsemblGenomes-Tr:CAB12757" /db_xref="GOA:P18157" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR005999" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10187" /db_xref="UniProtKB/Swiss-Prot:P18157" /translation="METYILSLDQGTTSSRAILFNKEGKIVHSAQKEFTQYFPHPGWV EHNANEIWGSVLAVIASVISESGISASQIAGIGITNQRETTVVWDKDTGSPVYNAIVW QSRQTSGICEELREKGYNDKFREKTGLLIDPYFSGTKVKWILDNVEGAREKAEKGELL FGTIDTWLIWKMSGGKAHVTDYSNASRTLMFNIYDLKWDDELLDILGVPKSMLPEVKP SSHVYAETVDYHFFGKNIPIAGAAGDQQSALFGQACFEEGMGKNTYGTGCFMLMNTGE KAIKSEHGLLTTIAWGIDGKVNYALEGSIFVAGSAIQWLRDGLRMFQDSSLSESYAEK VDSTDGVYVVPAFVGLGTPYWDSDVRGSVFGLTRGTTKEHFIRATLESLAYQTKDVLD AMEADSNISLKTLRVDGGAVKNNFLMQFQGDLLNVPVERPEINETTALGAAYLAGIAV GFWKDRSEIANQWNLDKRFEPELEEEKRNELYKGWQKAVKAAMAFK*" /label="glpK CDS" gene 927569..929059 /gene="glpK" /locus_tag="BSU_09290" /old_locus_tag="BSU09290" /label="glpK gene" promotor_-35 928370..928376 /Source="Nicolas_upshift_promotors" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="promotor_-35" promotor_-10 928391..928410 /Source="Nicolas_upshift_promotors" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="promotor_-10" upshifts 928401 /Source="Nicolas_upshifts" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="upshifts" S_feature 929060..929148 /Source="Nicolas_S_feature" /locus_tag="new_1004835_1004923" /HighExp="Sw, Etha, Salt, G150, Gly, Diami, T0.30H, B60, BC, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S322" downshifts 929105 /Source="Nicolas_upshifts" /id="D480" /incds=0 /nref=34 /ntot=91 /MaxReadThrough="7.63856" /MaxDrop="5.2045" /score="21.1943866" /energy="-28.7" /TU="U728,U729" /idTUdmin="U727" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box 929111..929211 /Source="Nicolas_upshift_promotors" /id="U730" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.566433566433566" /psig="0.154845154845155" /xcortree=277 /SigmaFactorBS="aggagagaccacagcaccaaagtgtaagcatgcactttggct gttgtggtctctttttctatttaccgtgacaacaaggaggaaacgtaatgatgaatca t" /listShort="glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 929171 /Source="Nicolas_upshifts" /id="U730" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.566433566433566" /psig="0.154845154845155" /xcortree=277 /SigmaFactorBS="aggagagaccacagcaccaaagtgtaagcatgcactttggct gttgtggtctctttttctatttaccgtgacaacaaggaggaaacgtaatgatgaatca t" /listShort="glpD, S323, pgcA" /GFF_Attribute="listLong" /label="upshifts" CDS 929200..930867 /gene="glpD" /locus_tag="BSU_09300" /old_locus_tag="BSU09300" /EC_number="1.1.3.21" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2127799, 8825777, 9595668, 10633102, 18946204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2127799, 8825777, 9595668, 10633102, 18946204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate oxidase (FAD-dependent)" /protein_id="NP_388811.2" /db_xref="EnsemblGenomes-Gn:BSU09300" /db_xref="EnsemblGenomes-Tr:CAB12758" /db_xref="GOA:P18158" /db_xref="InterPro:IPR000447" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR031656" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10188" /db_xref="UniProtKB/Swiss-Prot:P18158" /translation="MMNHQFSSLERDRMLTDMTKKTYDLFIIGGGITGAGTALDAASR GMKVALSEMQDFAAGTSSRSTKLVHGGLRYLKQFEVKMVAEVGKERAIVYENGPHVTT PEWMLLPFHKGGTFGSFTTSIGLRVYDFLAGVKKSERRSMLSAKETLQKEPLVKKDGL KGGGYYVEYRTDDARLTIEVMKEAVKFGAEPVNYSKVKELLYEKGKAVGVLIEDVLTK KEYKVYAKKIVNATGPWVDQLREKDHSKNGKHLQHTKGIHLVFDQSVFPLKQAVYFDT PDGRMVFAIPREGKTYVGTTDTVYKEALEHPRMTTEDRDYVIKSINYMFPELNITAND IESSWAGLRPLIHEEGKDPSEISRKDEIWTSDSGLITIAGGKLTGYRKMAEHIVDLVR DRLKEEGEKDFGPCKTKNMPISGGHVGGSKNLMSFVTAKTKEGIAAGLSEKDAKQLAI RYGSNVDRVFDRVEALKDEAAKRNIPVHILAEAEYSIEEEMTATPADFFVRRTGRLFF DINWVRTYKDAVIDFMSERFQWDEQAKNKHTENLNKLLHDAVVPLEQ*" /label="glpD CDS" gene 929200..930867 /gene="glpD" /locus_tag="BSU_09300" /old_locus_tag="BSU09300" /label="glpD gene" promotor_-35 930629..930634 /Source="Nicolas_upshift_promotors" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="promotor_-35" promotor_-10 930649..930667 /Source="Nicolas_upshift_promotors" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="promotor_-10" upshifts 930658 /Source="Nicolas_upshifts" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="upshifts" promotor_-35 930712..930718 /Source="Nicolas_upshift_promotors" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 930733 /Source="Nicolas_upshifts" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 930734..930752 /Source="Nicolas_upshift_promotors" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 930835 /Source="Nicolas_upshifts" /id="D481" /incds=0 /nref=13 /ntot=60 /MaxReadThrough="6.57605" /MaxDrop="4.31183" /score="11.5542287" /energy="-11.4" /TU="U728,U729,U730,U731,U732" /idTUdmin="U729" /TUdmin="-118" /isTUend="FALSE" /label="downshifts" S_feature 930880..930953 /Source="Nicolas_S_feature" /locus_tag="new_1006655_1006728" /HighExp="G150, Etha, Oxctl, H2O2, Gly, Diami, Paraq, Salt, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigEF, Sig-, SigB, SigA" /TUshortPSig="1, 0.995, 0.155, 1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S323" promotor_-35 930935..930942 /Source="Nicolas_upshift_promotors" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 930955 /Source="Nicolas_upshifts" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 930956..930975 /Source="Nicolas_upshift_promotors" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 930999..932744 /gene="pgcA" /locus_tag="BSU_09310" /old_locus_tag="BSU09310" /EC_number="5.4.2.2" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15640167, 17662947, 24097947, 26735940, 27684739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15640167, 17662947, 24097947, 26735940, 27684739; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-phosphoglucomutase" /protein_id="NP_388812.2" /db_xref="EnsemblGenomes-Gn:BSU09310" /db_xref="EnsemblGenomes-Tr:CAB12759" /db_xref="GOA:P18159" /db_xref="InterPro:IPR005841" /db_xref="InterPro:IPR005843" /db_xref="InterPro:IPR005844" /db_xref="InterPro:IPR005845" /db_xref="InterPro:IPR005846" /db_xref="InterPro:IPR016055" /db_xref="InterPro:IPR016066" /db_xref="InterPro:IPR036900" /db_xref="SubtiList:BG10189" /db_xref="UniProtKB/Swiss-Prot:P18159" /translation="MTWRKSYERWKQTEHLDLELKERLIELEGDEQALEDCFYKDLEF GTGGMRGEIGAGTNRMNIYTVRKASAGFAAYISKQGEEAKKRGVVIAYDSRHKSPEFA MEAAKTLATQGIQTYVFDELRPTPELSFAVRQLNAYGGIVVTASHNPPEYNGYKVYGD DGGQLPPKEADIVIEQVNAIENELTITVDEENKLKEKGLIKIIGEDIDKVYTEKLTSI SVHPELSEEVDVKVVFTPLHGTANKPVRRGLEALGYKNVTVVKEQELPDSNFSTVTSP NPEEHAAFEYAIKLGEEQNADILIATDPDADRLGIAVKNDQGKYTVLTGNQTGALLLH YLLSEKKKQGILPDNGVVLKTIVTSEIGRAVASSFGLDTIDTLTGFKFIGEKIKEYEA SGQYTFQFGYEESYGYLIGDFARDKDAIQAALLAVEVCAFYKKQGMSLYEALINLFNE YGFYREGLKSLTLKGKQGAEQIEAILASFRQNPPQKMAGKQVVTAEDYAVSKRTLLTE SKEEAIDLPKSNVLKYFLEDGSWFCLRPSGTEPKVKFYFAVKGSSLEDSEKRLAVLSE DVMKTVDEIVESTAK*" /label="pgcA CDS" gene 930999..932744 /gene="pgcA" /locus_tag="BSU_09310" /old_locus_tag="BSU09310" /label="pgcA gene" downshifts 932733 /Source="Nicolas_upshifts" /id="D482" /incds=0 /nref=227 /ntot=264 /MaxReadThrough="4.80136" /MaxDrop="5.89896" /score="26.7163878" /energy="-13" /TU="U732,U733" /idTUdmin="U728" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" S_feature 932778..932847 /Source="Nicolas_S_feature" /locus_tag="new_1008553_1008622" /HighExp="Etha, H2O2, B36, dia15, Paraq, G150, LoTm, S8, Oxctl, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S324" misc_feature 932849..932868 /Source="Nicolas_upshift_promotors" /id="U734" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.62037962037962" /psig="0.998001998001998" /xcortree=3137 /SigmaFactorBS="tttctcatccaaaagtctgaaagaaaatcatcctacaagtga agcaatgaaatacaaaaaACTGGTATAATCTTAAATACaagatcaatgccggagtgag a" /listShort="yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 932849 /Source="Nicolas_upshifts" /id="U734" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.62037962037962" /psig="0.998001998001998" /xcortree=3137 /SigmaFactorBS="tttctcatccaaaagtctgaaagaaaatcatcctacaagtga agcaatgaaatacaaaaaACTGGTATAATCTTAAATACaagatcaatgccggagtgag a" /listShort="yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="upshifts" CDS 932893..934032 /gene="yhcY" /locus_tag="BSU_09320" /old_locus_tag="BSU09320" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 16816187, 16267314, 20639339, 21335452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16816187, 16267314, 20639339, 21335452; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YhcZ]" /protein_id="NP_388813.1" /db_xref="EnsemblGenomes-Gn:BSU09320" /db_xref="EnsemblGenomes-Tr:CAB12760" /db_xref="GOA:O07527" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13005" /db_xref="UniProtKB/Swiss-Prot:O07527" /translation="MSKTRMEKLKTLKTIAETLNQGHDIKATLDEVLKELLSLTNLQS GWIFLIEEDGSYTLAADAYLPPALSRKEKVLMCEGECYCLTKFNNGGLRKAANIMNCK RIESAENLHCFDTEGITHHATVPLEDGDRRFGLLNVAAAGKTMFDEEELHLLESVAFQ IGTAIQRMRLSEYQQKNALLMERNRLAQELHDSVNQMLFSVSLTAKAAKTLTKDENLQ QMIDFIQNLSQDALAEMKALIWQLRPGGLEKGLAEAIKSYGALIGLKIIFTQKGCPVL TDEQEHMLWRVVQEALNNCKKHAGTDTAYVSLTASLCHAELDIIDHGAGFRYEAHAGL PSLGIKGMKERAEKAGAKFWIESALGTGTKLSIRLPLKSRKGGAV*" /label="yhcY CDS" gene 932893..934032 /gene="yhcY" /locus_tag="BSU_09320" /old_locus_tag="BSU09320" /label="yhcY gene" CDS 934029..934673 /gene="yhcZ" /locus_tag="BSU_09330" /old_locus_tag="BSU09330" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 16816187, 16267314, 20639339, 21335452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16816187, 16267314, 20639339, 21335452; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YhcY]" /protein_id="NP_388814.1" /db_xref="EnsemblGenomes-Gn:BSU09330" /db_xref="EnsemblGenomes-Tr:CAB12761" /db_xref="GOA:O07528" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13006" /db_xref="UniProtKB/Swiss-Prot:O07528" /translation="MKIVIADDHHVVRKGLRFFFATQDDIEVVGEAATGLEALRVIEE TKPDLVLMDLSMPEMDGIQAIKKAIQQFPDTNIIVLTSYSDQEHVIPALQAGAKAYQL KDTEPEELVKTRQVHGGEYKLSTAIMPHVLTHMKNQHDPEKEKYYQLTRREKDVLTEI ANGKSNKEIAAALFISEKTVKTHVSNLLAKLEVADRTQAALFAVKYNLNGEISK*" /label="yhcZ CDS" gene 934029..934673 /gene="yhcZ" /locus_tag="BSU_09330" /old_locus_tag="BSU09330" /label="yhcZ gene" CDS 934670..935194 /gene="azr" /locus_tag="BSU_09340" /old_locus_tag="BSU09340" /EC_number="1.7.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15184374, 16816187, 20639339; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxidoreductase, NAD(P)H-FMN and ferric iron reductase (azoreductase)" /protein_id="NP_388815.1" /db_xref="EnsemblGenomes-Gn:BSU09340" /db_xref="EnsemblGenomes-Tr:CAB12762" /db_xref="GOA:O07529" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR029039" /db_xref="PDB:1NNI" /db_xref="PDB:2GSW" /db_xref="PDB:3GFQ" /db_xref="PDB:3GFR" /db_xref="PDB:3GFS" /db_xref="SubtiList:BG13007" /db_xref="UniProtKB/Swiss-Prot:O07529" /translation="MNMLVINGTPRKHGRTRIAASYIAALYHTDLIDLSEFVLPVFNG EAEQSELLKVQELKQRVTKADAIVLLSPEYHSGMSGALKNALDFLSSEQFKYKPVALL AVAGGGKGGINALNNMRTVMRGVYANVIPKQLVLDPVHIDVENATVAENIKESIKELV EELSMFAKAGNPGV*" /label="azr CDS" gene 934670..935194 /gene="azr" /locus_tag="BSU_09340" /old_locus_tag="BSU09340" /label="azr gene" downshifts 935159 /Source="Nicolas_upshifts" /id="D483" /incds=0 /nref=72 /ntot=215 /MaxReadThrough="2.90096" /MaxDrop="4.78561" /score="27.1269177" /energy="-17.2" /TU="NA" /idTUdmin="U734" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(935209..935451) /gene="yhdB" /locus_tag="BSU_09350" /old_locus_tag="BSU09350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388816.1" /db_xref="EnsemblGenomes-Gn:BSU09350" /db_xref="EnsemblGenomes-Tr:CAB12763" /db_xref="InterPro:IPR025431" /db_xref="SubtiList:BG13008" /db_xref="UniProtKB/Swiss-Prot:O07530" /translation="MDYADYDKALYYTHRSQWDNLLILMVRTEDDLLSKRIEHFLHAY HFEQDYAVLEKMLYSLLRYIDHATELTYEDQIALLT*" /label="yhdB CDS" gene complement(935209..935451) /gene="yhdB" /locus_tag="BSU_09350" /old_locus_tag="BSU09350" /label="yhdB gene" downshifts complement(935230) /Source="Nicolas_upshifts" /id="D484" /incds=0 /nref=39 /ntot=84 /MaxReadThrough="-0.0235599999999998" /MaxDrop="7.78706" /score="12.0066876" /energy="-17.2" /TU="NA" /idTUdmin="U735" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(935487..935498) /Source="Nicolas_upshift_promotors" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(935498) /Source="Nicolas_upshifts" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(935512..935519) /Source="Nicolas_upshift_promotors" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 935586..935592 /Source="Nicolas_upshift_promotors" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 935606..935617 /Source="Nicolas_upshift_promotors" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 935616 /Source="Nicolas_upshifts" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="upshifts" CDS 935652..935975 /gene="yhdC" /locus_tag="BSU_09360" /old_locus_tag="BSU09360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388817.1" /db_xref="EnsemblGenomes-Gn:BSU09360" /db_xref="EnsemblGenomes-Tr:CAB12764" /db_xref="InterPro:IPR024987" /db_xref="SubtiList:BG13009" /db_xref="UniProtKB/Swiss-Prot:O07531" /translation="MKSLPYTIALLFCGLIIVSMAAKGHSTDTDESVQKWEQLAWSKI QDEYKGASFSDYAYMGRTEVNDQQTKDVFRVTVRQKDDTFSVRAEVYFHPVTNHMISI NVFRL*" /label="yhdC CDS" gene 935652..935975 /gene="yhdC" /locus_tag="BSU_09360" /old_locus_tag="BSU09360" /label="yhdC gene" S_feature 935976..937842 /Source="Nicolas_S_feature" /locus_tag="new_1011751_1013617" /HighExp="S8, S5, S7, S6, S4, C30, Sw, ferm, S3, BC" /AntisenseName="lytF" /AntisenseCor="-0.65564579825076796" /AntisenseRegPval="-33.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S325" CDS complement(936017..937483) /gene="lytF" /locus_tag="BSU_09370" /old_locus_tag="BSU09370" /EC_number="3.4.-.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10206711, 14594841, 18761694, 18761696, 23091053, 25288647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10206711, 14594841, 18761694, 18761696, 23091053, 25288647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="gamma-D-glutamate-meso-diaminopimelate muropeptidase (major autolysin, vegetative)" /protein_id="NP_388818.2" /db_xref="EnsemblGenomes-Gn:BSU09370" /db_xref="EnsemblGenomes-Tr:CAB12776" /db_xref="GOA:O07532" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13010" /db_xref="UniProtKB/Swiss-Prot:O07532" /translation="MKKKLAAGLTASAIVGTTLVVTPAEAATIKVKSGDSLWKLAQTY NTSVAALTSANHLSTTVLSIGQTLTIPGSKSSTSSSTSSSTTKKSGSSVYTVKSGDSL WLIANEFKMTVQELKKLNGLSSDLIRAGQKLKVSGTVSSSSSSSKKSNSNKSSSSSSK SSSNKSSSSSSSTGTYKVQLGDSLWKIANKVNMSIAELKVLNNLKSDTIYVNQVLKTK SSGSDTSSKDNSSKSNQTSATTKYTVKSGDSLWKIANNYNLTVQQIRNINNLKSDVLY VGQVLKLTGKASSGSSSSSSSSSNASSGTTTTYTVKSGDSLWVIAQKFNVTAQQIREK NNLKTDVLQVGQKLVISGKASSSSSSGSSNTTSSTSAKINTMISAAKAQLGVPYRWGG TTPSGFDCSGFIYYVLNKVTSVSRLTAAGYWNTMKSVSQPAVGDFVFFSTYKAGPSHV GIYLGNGEFINANDSGVVISNMNNSYWKQRYLGAKRYF*" /label="lytF CDS" gene complement(936017..937483) /gene="lytF" /locus_tag="BSU_09370" /old_locus_tag="BSU09370" /label="lytF gene" downshifts complement(936029) /Source="Nicolas_upshifts" /id="D485" /incds=0 /nref=121 /ntot=216 /MaxReadThrough="2.34529" /MaxDrop="4.33563" /score="24.6732339" /energy="-14.2" /TU="NA" /idTUdmin="U737" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts complement(936116) /Source="Nicolas_upshifts" /id="D486" /incds=1 /nref=1 /ntot=87 /MaxReadThrough="5.73069" /MaxDrop="2.6306" /score="24.6732339" /energy="-14.2" /TU="U737" /idTUdmin="U737" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(937523..937541) /Source="Nicolas_upshift_promotors" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(937535) /Source="Nicolas_upshifts" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(937555..937562) /Source="Nicolas_upshift_promotors" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(937636..938076) /gene="nsrR" /locus_tag="BSU_09380" /old_locus_tag="BSU09380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16885456, 19006327, 21091510, 26887943, 27778474, 28425466, 28439033" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16885456, 19006327, 21091510, 26887943, 27778474, 28425466, 28439033; Product type r: regulator" /codon_start=1 /transl_table=11 /product="NO-dependent activator of the ResDE regulon (Fe-S NO binding site)" /protein_id="NP_388819.1" /db_xref="EnsemblGenomes-Gn:BSU09380" /db_xref="EnsemblGenomes-Tr:CAB12777" /db_xref="GOA:O07573" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13011" /db_xref="UniProtKB/Swiss-Prot:O07573" /translation="MKLTNYTDYSLRVLIFLAAERPGELSNIKQIAETYSISKNHLMK VIYRLGQLGYVETIRGRGGGIRLGMDPEDINIGEVVRKTEDDFNIVECFDANKNLCVI SPVCGLKHVLNEALLAYLAVLDKYTLRDLVKNKEDIMKLLKMKE*" /label="nsrR CDS" gene complement(937636..938076) /gene="nsrR" /locus_tag="BSU_09380" /old_locus_tag="BSU09380" /label="nsrR gene" downshifts complement(937666) /Source="Nicolas_upshifts" /id="D487" /incds=0 /nref=205 /ntot=265 /MaxReadThrough="3.11158" /MaxDrop="6.87147" /score="5.96186156" /energy="-7.8" /TU="U739" /idTUdmin="U740" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" promotor_-35 938064..938070 /Source="Nicolas_upshift_promotors" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 938084..938095 /Source="Nicolas_upshift_promotors" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 938086..938196 /Source="Nicolas_S_feature" /locus_tag="new_1013861_1013971" /HighExp="S8, S7, S4, Sw, S5, S6, BC, B60, nit, Pyr" /AntisenseName="ygxB" /AntisenseCor="-0.211236686077168" /AntisenseRegPval="-3.3" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.904" /TUlongSig="NA" /TUlongPSig="NA" /label="S326" upshifts 938086 /Source="Nicolas_upshifts" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(938098..938117) /Source="Nicolas_upshift_promotors" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(938114) /Source="Nicolas_upshifts" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(938129..938135) /Source="Nicolas_upshift_promotors" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 938155 /Source="Nicolas_upshifts" /id="D488" /incds=0 /nref=10 /ntot=68 /MaxReadThrough="1.05981" /MaxDrop="6.25571" /score="22.5171081" /energy="-11.6" /TU="NA" /idTUdmin="U738" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(938183..939841) /gene="ygxB" /locus_tag="BSU_09390" /old_locus_tag="BSU09390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388820.1" /db_xref="EnsemblGenomes-Gn:BSU09390" /db_xref="EnsemblGenomes-Tr:CAB12778" /db_xref="GOA:P37874" /db_xref="InterPro:IPR008910" /db_xref="SubtiList:BG10181" /db_xref="UniProtKB/Swiss-Prot:P37874" /translation="MYEPARQKMIVSLGQEKIPPAHSSVCLLDKWVNTHHTTKKERYQ LNVADVFSSYLSKLPNVIIALLVLLIGWAIAKIIEKAVYKGLSKTKIDDKLFAGKKPS RYSSEKVISKVVYFIALIIVFILFFNILHLTTVASPFVSMLSAIAAAIPSVLKAGLIL LLGWAAASVLSFLVKKIGMKLNTSDKLRKWNLVSEGKDIHQAVNTASQIVFYLVLLVF LPGVLSSLKISGISGPFTNMMESVLAFLPKLFAAALIVLIGWLVARLVRDIITNFLAS IGTERFAARMGLSIYLKDTSLSAVIGTIAYVLIMIPVVISALDQLDVAGISKPAVSML NTILNMLPNIMIAIVLVLAGIWAGKWVKSMVSGLLHRAGFDSVLGKMGMEAGTPAKLS LSQVVGMIAQIIVILLFTAEALQIVRLHFLVEIATGIIAYLPNVLVAVFILGLGLYAG ELVRKVLASMIKGQEFKSLAPIAKYTIIALAFFMALDQLGVAATIVNSAFIIVLSGFA LAFGLSFGLGGKDFASRYLSTFERKMQNTEIEKNRKNQNPPNDM*" /label="ygxB CDS" gene complement(938183..939841) /gene="ygxB" /locus_tag="BSU_09390" /old_locus_tag="BSU09390" /label="ygxB gene" downshifts complement(938188) /Source="Nicolas_upshifts" /id="D489" /incds=0 /nref=6 /ntot=40 /MaxReadThrough="8.34865" /MaxDrop="5.55332" /score="-5.46969987" /energy="-14.5" /TU="U740" /idTUdmin="U740" /TUdmin="-532" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(939732..939750) /Source="Nicolas_upshift_promotors" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(939752) /Source="Nicolas_upshifts" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(939764..939770) /Source="Nicolas_upshift_promotors" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 939813..939818 /Source="Nicolas_upshift_promotors" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 939834..939852 /Source="Nicolas_upshift_promotors" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 939847 /Source="Nicolas_upshifts" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="upshifts" CDS 939872..941278 /gene="spoVR" /locus_tag="BSU_09400" /old_locus_tag="BSU09400" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8144469, 14680823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8144469, 14680823; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="involved in spore cortex synthesis (stage V sporulation, conserved in non sporulating bacteria" /protein_id="NP_388821.1" /db_xref="EnsemblGenomes-Gn:BSU09400" /db_xref="EnsemblGenomes-Tr:CAB12779" /db_xref="GOA:P37875" /db_xref="InterPro:IPR007390" /db_xref="SubtiList:BG10182" /db_xref="UniProtKB/Swiss-Prot:P37875" /translation="MNAEEKKGLQRAIEEITEIAKGFGLDFYPMRYEICPAEIIYTFG AYGMPTRFSHWSFGKQFHKMKLHYDLGLSKIYELVINSDPCYAFLLDSNSLIQNKLIV AHVLAHCDFFKNNCRFQNTKRDMVESMAATAERIKHYEQVHGIKEVESFLDAILSIQE HIDPSLVRPKLQWSVDDEEEEIEEAATPYDDLWSLDEKKPKKQVKKSKKPFPPRPEKD ILLFIEEHSRELEPWQRDILTMMREEMLYFWPQLETKIMNEGWASYWHQRIIRELDLT SDEAIEFAKLNAGVVQPSKTGINPYYLGLKIFEDIEKRYNNPTEEMKKMGVQPDSGRE KMFEVREIESDISFIRNYLTKELVMREDLYLFQKQGRDYKIIDKQWKSVRDQLVSMRV NGGFPYLTVNDGDYMKNNELYIKHWYEGIELDLKYLEKVLPYLFQLWGRSVHIESVLE DKEVMFSYDGKGVHRRYL*" /label="spoVR CDS" gene 939872..941278 /gene="spoVR" /locus_tag="BSU_09400" /old_locus_tag="BSU09400" /label="spoVR gene" downshifts 941258 /Source="Nicolas_upshifts" /id="D490" /incds=0 /nref=43 /ntot=84 /MaxReadThrough="1.30719" /MaxDrop="6.74388" /score="26.4488835" /energy="-11.5" /TU="NA" /idTUdmin="U741" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(941308..942693) /gene="phoA" /locus_tag="BSU_09410" /old_locus_tag="BSU09410" /EC_number="3.1.3.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8830275, 10913081, 12897025, 16491025" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830275, 10913081, 12897025, 16491025; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkaline phosphatase A" /protein_id="NP_388822.2" /db_xref="EnsemblGenomes-Gn:BSU09410" /db_xref="EnsemblGenomes-Tr:CAB12780" /db_xref="GOA:P19406" /db_xref="InterPro:IPR001952" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR018299" /db_xref="SubtiList:BG10183" /db_xref="UniProtKB/Swiss-Prot:P19406" /translation="MKKMSLFQNMKSKLLPIAAVSVLTAGIFAGAELQQTEKASAKKQ DKAEIRNVIVMIGDGMGTPYIRAYRSMKNNGDTPNNPKLTEFDRNLTGMMMTHPDDPD YNITDSAAAGTALATGVKTYNNAIGVDKNGKKVKSVLEEAKQQGKSTGLVATSEINHA TPAAYGAHNESRKNMDQIANSYMDDKIKGKHKIDVLLGGGKSYFNRKDRNLTKEFKQA GYSYVTTKQALKKNKDQQVLGLFADGGLAKALDRDSKTPSLKDMTVSAIDRLNQNKKG FFLMVEGSQIDWAAHDNDTVGAMSEVKDFEQAYKAAIEFAKKDKHTLVIATADHTTGG FTIGANGEKNWHAEPILSAKKTPEFMAKKISEGKPVKDVLARYANLKVTSEEIKSVEA AAQADKSKGASKAIIKIFNTRSNSGWTSTDHTGEEVPVYAYGPGKEKFRGLINNTDQA NIIFKILKTGK*" /label="phoA CDS" gene complement(941308..942693) /gene="phoA" /locus_tag="BSU_09410" /old_locus_tag="BSU09410" /label="phoA gene" downshifts complement(941334) /Source="Nicolas_upshifts" /id="D491" /incds=0 /nref=51 /ntot=178 /MaxReadThrough="1.90638" /MaxDrop="5.795" /score="22.2126775" /energy="-13.2" /TU="NA" /idTUdmin="U742" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(942720) /Source="Nicolas_upshifts" /id="U742" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.94105894105894" /psig="0.035964035964036" /xcortree=8 /SigmaFactorBS="acaaggctttacttattgtttacatgatcaacagccgcaTTT AACAAAGTTtccctaacatgataaacggaatacattaaaggaggcatgaaaaaaatga g" /listShort="phoA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(942722..944253) /Source="Nicolas_S_feature" /locus_tag="new_1018497_1020028_c" /HighExp="Etha, Salt, B60, Heat, M9-stat, T5.0H, T0.30H, T4.0H, T3.30H, T2.30H" /AntisenseName="lytE" /AntisenseCor="-0.65081062481616203" /AntisenseRegPval="-33.1" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA" /TUshortPSig="0.966, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S327" misc_feature complement(942730..942741) /Source="Nicolas_upshift_promotors" /id="U742" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.94105894105894" /psig="0.035964035964036" /xcortree=8 /SigmaFactorBS="acaaggctttacttattgtttacatgatcaacagccgcaTTT AACAAAGTTtccctaacatgataaacggaatacattaaaggaggcatgaaaaaaatga g" /listShort="phoA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 942849..942856 /Source="Nicolas_upshift_promotors" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 942869..942888 /Source="Nicolas_upshift_promotors" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 942875..943162 /Source="Nicolas_S_feature" /locus_tag="new_1018650_1018937" /HighExp="T-5.40H, Cold, LoTm, T-4.40H, UNK1, T5.0H, GM-0.1, T3.30H, S1, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S328" upshifts 942875 /Source="Nicolas_upshifts" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 943125..943128 /Source="Nicolas_upshift_promotors" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 943143..943162 /Source="Nicolas_upshift_promotors" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 943164 /Source="Nicolas_upshifts" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="upshifts" CDS 943223..944227 /gene="lytE" /locus_tag="BSU_09420" /old_locus_tag="BSU09420" /EC_number="3.4.-.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16855244, 16950129, 9457885, 21541672, 22139507, 27002131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16855244, 16950129, 9457885, 21541672, 22139507, 27002131; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cell wall dl-endopeptidase; phosphatase-associated protein (major autolysin)" /protein_id="NP_388823.2" /db_xref="EnsemblGenomes-Gn:BSU09420" /db_xref="EnsemblGenomes-Tr:CAB12781" /db_xref="GOA:P54421" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11406" /db_xref="UniProtKB/Swiss-Prot:P54421" /translation="MKKQIITATTAVVLGSTLFAGAASAQSIKVKKGDTLWDLSRKYD TTISKIKSENHLRSDIIYVGQTLSINGKSTSSKSSSSSSSSSTYKVKSGDSLWKISKK YGMTINELKKLNGLKSDLLRVGQVLKLKGSTSSSSSSSSKVSSSSTSTYKVKSGDSLS KIASKYGTTVSKLKSLNGLKSDVIYVNQVLKVKGTSTSSSKPASSSSSSSSKTSSTSL NVSKLVSDAKALVGTPYKWGGTTTSGFDCSGFIWYVLNKQTSVGRTSTAGYWSSMKSI ASPSVGDFVFFTTYKSGPSHMGIYIGNNSFIHAGSDGVQISSLNNSYWKPRYLGAKRF *" /label="lytE CDS" gene 943223..944227 /gene="lytE" /locus_tag="BSU_09420" /old_locus_tag="BSU09420" /label="lytE gene" downshifts 944089 /Source="Nicolas_upshifts" /id="D492" /incds=1 /nref=1 /ntot=117 /MaxReadThrough="6.89938" /MaxDrop="2.1687" /score="26.3320532" /energy="-9.8" /TU="U743,U744" /idTUdmin="U743" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts 944219 /Source="Nicolas_upshifts" /id="D493" /incds=0 /nref=53 /ntot=190 /MaxReadThrough="3.64545" /MaxDrop="6.08377" /score="26.3320532" /energy="-9.8" /TU="U744" /idTUdmin="U743" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" upshifts complement(944253) /Source="Nicolas_upshifts" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(944260..944275) /Source="Nicolas_upshift_promotors" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 944265 /Source="Nicolas_upshifts" /id="D494" /incds=0 /nref=1 /ntot=47 /MaxReadThrough="2.99" /MaxDrop="3.76174" /score="26.3320532" /energy="-9.8" /TU="U744" /idTUdmin="U743" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 complement(944287..944296) /Source="Nicolas_upshift_promotors" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(944298..945173) /gene="citR" /locus_tag="BSU_09430" /old_locus_tag="BSU09430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8045899, 10869065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045899, 10869065; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator CitR (LysR family)" /protein_id="NP_388824.2" /db_xref="EnsemblGenomes-Gn:BSU09430" /db_xref="EnsemblGenomes-Tr:CAB12782" /db_xref="GOA:P39127" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10853" /db_xref="UniProtKB/Swiss-Prot:P39127" /translation="MDFKWLHTFVTAAKYENFRKTAETLFLSQPTVTVHIKQLEKEIS CKLFERKGRQIQLTDEGRAYLPYALRLLDDYENSMAELHRVRQGYSQTLQLAVSPLIA DTVLPSVMKRYTAMNTETEMAVTIFESAEIASLIKAGEADIGLSCLKVQSSSLSCHCL YKDPVVLVAPPDKRFIEDNEIDAKEVLEQYLLLTHNHPDYWDDLLRQVRMTFPFVRTM KVTQTHITKRFIKEGLGVSFLPLSTVKRELAEKQMIRIPYQSVQLPYAGAYAIALYEN KKEKKFLDFLSHFHF*" /label="citR CDS" gene complement(944298..945173) /gene="citR" /locus_tag="BSU_09430" /old_locus_tag="BSU09430" /label="citR gene" promotor_-35 945226..945227 /Source="Nicolas_upshift_promotors" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(945239..945258) /Source="Nicolas_upshift_promotors" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="promotor_-10" promotor_-10 945244..945263 /Source="Nicolas_upshift_promotors" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(945245) /Source="Nicolas_upshifts" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="upshifts" upshifts 945254 /Source="Nicolas_upshifts" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(945273..945278) /Source="Nicolas_upshift_promotors" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="promotor_-35" CDS 945282..946382 /gene="citA" /locus_tag="BSU_09440" /old_locus_tag="BSU09440" /EC_number="2.3.3.16" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:4211224, 8045898, 8045899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4211224, 8045898, 8045899; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="citrate synthase I" /protein_id="NP_388825.2" /db_xref="EnsemblGenomes-Gn:BSU09440" /db_xref="EnsemblGenomes-Tr:CAB12783" /db_xref="GOA:P39119" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR016143" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="PDB:2C6X" /db_xref="SubtiList:BG10854" /db_xref="UniProtKB/Swiss-Prot:P39119" /translation="MVHYGLKGITCVETSISHIDGEKGRLIYRGHHAKDIALNHSFEE AAYLILFGKLPSTEELQVFKDKLAAERNLPEHIERLIQSLPNNMDDMSVLRTVVSALG ENTYTFHPKTEEAIRLIAITPSIIAYRKRWTRGEQAIAPSSQYGHVENYYYMLTGEQP SEAKKKALETYMILATEHGMNASTFSARVTLSTESDLVSAVTAALGTMKGPLHGGAPS AVTKMLEDIGEKEHAEAYLKEKLEKGERLMGFGHRVYKTKDPRAEALRQKAEEVAGND RDLDLALHVEAEAIRLLEIYKPGRKLYTNVEFYAAAVMRAIDFDDELFTPTFSASRMV GWCAHVLEQAENNMIFRPSAQYTGAIPEEVLS*" /label="citA CDS" gene 945282..946382 /gene="citA" /locus_tag="BSU_09440" /old_locus_tag="BSU09440" /label="citA gene" promotor_-35 946393..946399 /Source="Nicolas_upshift_promotors" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 946414..946432 /Source="Nicolas_upshift_promotors" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 946419 /Source="Nicolas_upshifts" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="upshifts" CDS 946456..947325 /gene="yhdF" /locus_tag="BSU_09450" /old_locus_tag="BSU09450" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513, 18643936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)-dependent dehydrogenase" /protein_id="NP_388826.1" /db_xref="EnsemblGenomes-Gn:BSU09450" /db_xref="EnsemblGenomes-Tr:CAB12784" /db_xref="GOA:O07575" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13012" /db_xref="UniProtKB/Swiss-Prot:O07575" /translation="MNPMDRQTEGQEPQHQDRQPGIESKMNPLPLSEDEDYRGSGKLK GKVAIITGGDSGIGRAAAIAFAKEGADISILYLDEHSDAEETRKRIEKENVRCLLIPG DVGDENHCEQAVQQTVDHFGKLDILVNNAAEQHPQDSILNISTEQLEKTFRTNIFSMF HMTKKALPHLQEGCAIINTTSITAYEGDTALIDYSSTKGAIVSFTRSMAKSLADKGIR VNAVAPGPIWTPLIPATFPEEKVKQHGLDTPMGRPGQPVEHAGAYVLLASDESSYMTG QTIHVNGGRFIST*" /label="yhdF CDS" gene 946456..947325 /gene="yhdF" /locus_tag="BSU_09450" /old_locus_tag="BSU09450" /label="yhdF gene" downshifts 947333 /Source="Nicolas_upshifts" /id="D495" /incds=0 /nref=27 /ntot=130 /MaxReadThrough="8.65426" /MaxDrop="6.48064" /score="18.1511963" /energy="-8.2" /TU="U748" /idTUdmin="U747" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 947410..947413 /Source="Nicolas_upshift_promotors" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 947425 /Source="Nicolas_upshifts" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 947428..947447 /Source="Nicolas_upshift_promotors" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 947473..947492 /Source="Nicolas_upshift_promotors" /id="U750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.522477522477522" /xcortree=652 /SigmaFactorBS="tttttgcaattttatatataatattgagtaggagaaaggaat gattcgcgaccagTACAAATATAGTAGAAAAAAaagaataatgaccattgttactcat g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 947478..947574 /Source="Nicolas_S_feature" /locus_tag="new_1023253_1023349" /HighExp="Etha, T2.30H, T-0.40H, T2.0H, T1.30H, S1, GM-0.2, T3.0H, T-1.40H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.27332800000000002" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="0.522, 0.998, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S329" upshifts 947478 /Source="Nicolas_upshifts" /id="U750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.522477522477522" /xcortree=652 /SigmaFactorBS="tttttgcaattttatatataatattgagtaggagaaaggaat gattcgcgaccagTACAAATATAGTAGAAAAAAaagaataatgaccattgttactcat g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="upshifts" CDS 947575..948972 /gene="bcaP" /locus_tag="BSU_09460" /old_locus_tag="BSU09460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16621821, 16850406, 21097623, 25645558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16621821, 16850406, 21097623, 25645558; Product type t : transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid transporter or methylthioribose-degradation metabolite exporter" /protein_id="NP_388827.1" /db_xref="EnsemblGenomes-Gn:BSU09460" /db_xref="EnsemblGenomes-Tr:CAB12785" /db_xref="GOA:O07576" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004758" /db_xref="SubtiList:BG13013" /db_xref="UniProtKB/Swiss-Prot:O07576" /translation="MKGSVFRKKSIQDLIAATSGEKSLKRELGAFDLTLLGIGAIIGT GIFVLTGTGAVTAGPGLTISFVVAALACLFAALSYAEFASSVPVSGSVYTFTYATLGE LMAFIIGWDLILEYMLAVSAVSVGWSGYFQSFLSGLGIHLPVALTAAPGAVKGTFTLF NLPAFVIVMAITYLLYLGIKESKRVNNIMVILKILVVLLFIAVAAVYVKPHNWQPFMP MGFGGVFSAAALVFFAFIGFDAVSSAAEETKNPAKDLPKGIIFSLLVCTILYVTVSAI MTGVIPFAQFAGVDHPVSLVLQSAGQNWVAGIIDIGAVLGMTTVMLVMLYGQTRVMFA MSRDGLVPGSLSKVHPKHKTPYVATWFFGTMSALLGSLVPLDELAKLVNIGTLSAFVL ISVAVIVLRKKQPDLPRAFKCPGVPVIPGLAILFCLFLILNLGWVTIVRFLVWLLIGL VIYFLYSRKHSKLNQ*" /label="bcaP CDS" gene 947575..948972 /gene="bcaP" /locus_tag="BSU_09460" /old_locus_tag="BSU09460" /label="bcaP gene" downshifts 948952 /Source="Nicolas_upshifts" /id="D496" /incds=0 /nref=116 /ntot=188 /MaxReadThrough="3.41176" /MaxDrop="5.29633" /score="5.08283681" /energy="-12.3" /TU="U748,U749" /idTUdmin="U750" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 949033..949037 /Source="Nicolas_upshift_promotors" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 949053..949072 /Source="Nicolas_upshift_promotors" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 949060 /Source="Nicolas_upshifts" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="upshifts" CDS 949090..950445 /gene="yhdH" /locus_tag="BSU_09470" /old_locus_tag="BSU09470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent transporter" /protein_id="NP_388828.1" /db_xref="EnsemblGenomes-Gn:BSU09470" /db_xref="EnsemblGenomes-Tr:CAB12786" /db_xref="GOA:O07577" /db_xref="InterPro:IPR000175" /db_xref="SubtiList:BG13014" /db_xref="UniProtKB/Swiss-Prot:O07577" /translation="MSEQKPVQWASKIGFVMAAAGSAIGLGAIWKFPYVAGTNGGGAF FLIFVLFTILLGYPLLVGEFIFGRRNQTNAIDAYKKEAPRSAWFLTGWIGVAACFLVL SFYSVIGGWILLYIVKTASGSLSGLSQAQYGALFASIIQNPVQTLAAQLVFMALTVLV VARGVQKGIERVSAVMMPILFLLFILLVLRSLTLNGAMEGVKFLLVPHFGDLTPESIL FALGQAFFTLTLGVSVMVTYSSYLPKTQNIPRSAASIVLMNIIVTLLAGLAIFPAVFS FGFQPNEGPTLLFTVLPAVFEQLPFGTLFFIGFLVAFLFAALTSAFSMVEIIVATIGK GDEKKRKKLSWTSGLLIFLVGIPCCLSYGVLSDVHLFGKTFFDIADFTVSNVLMPSGA LLISLFIPLKISKSELLAEMRNGSNAGKAFFYTWFYLLRFIVPLAIIIVFLNLIGILS F*" /label="yhdH CDS" gene 949090..950445 /gene="yhdH" /locus_tag="BSU_09470" /old_locus_tag="BSU09470" /label="yhdH gene" downshifts 950426 /Source="Nicolas_upshifts" /id="D497" /incds=0 /nref=184 /ntot=244 /MaxReadThrough="1.73756" /MaxDrop="6.09379" /score="40.1809389" /energy="-14.8" /TU="NA" /idTUdmin="U751" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(950480..951889) /gene="yhdI" /locus_tag="BSU_09480" /old_locus_tag="BSU09480" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388829.1" /db_xref="EnsemblGenomes-Gn:BSU09480" /db_xref="EnsemblGenomes-Tr:CAB12787" /db_xref="GOA:O07578" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13015" /db_xref="UniProtKB/Swiss-Prot:O07578" /translation="MDITPFLDKKSKTPLYEQLYTFFKQEISHARITKGTRLPSKRRL SSLLDVSTATIERAYEQLTAEGYVKSKPKIGWFAAEVEPGFPTAPDHFQQSVQPGLHQ KNAPAIDFHQGSVDPTLFPFNAWRKSIVKSLDRYSGSFHTSGDPQGEYELRHMIARFV RLSRGVNCEPGQIIIGAGTTVLLQNLCLSLKPGTKIGFEEPGFHRSRRMFEANHMDVT PICSDAEGVLPDELYRQNPYLMYTTPSHQFPIGTIMTITRRQELLAWAAETNSFIIED DYDGEFRYSGHPIPSLQGLDPNGRVIYLGTFSKSLLPSLRLSFMIVPPELMEPIQNNV QLMKQTVSAHSQLALADFIETGEWQKHINRMRSLYRKKHAVLLEAIRSELGNTVEILG KNSGLHILLRLLFPASEEEAIQAAADHGVTLYPVSPSYIEQTPFTSVLIGYGGLSEED IRLGIQKLKTAWAPLISSY*" /label="yhdI CDS" gene complement(950480..951889) /gene="yhdI" /locus_tag="BSU_09480" /old_locus_tag="BSU09480" /label="yhdI gene" promotor_-35 951938..951941 /Source="Nicolas_upshift_promotors" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 951956..951975 /Source="Nicolas_upshift_promotors" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 951958 /Source="Nicolas_upshifts" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(951960..951979) /Source="Nicolas_upshift_promotors" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(951972) /Source="Nicolas_upshifts" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(951995..951999) /Source="Nicolas_upshift_promotors" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 951999..952427 /gene="yhdJ" /locus_tag="BSU_09490" /old_locus_tag="BSU09490" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388830.1" /db_xref="EnsemblGenomes-Gn:BSU09490" /db_xref="EnsemblGenomes-Tr:CAB12788" /db_xref="GOA:O07579" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13016" /db_xref="UniProtKB/Swiss-Prot:O07579" /translation="MIHMKQLTSKEEWAESYPIMSELRTELDIETYLQRLEACVQKES YMLFALYENTAIRALCGALPRVSIHKGEHLWIADLVTTAPCRSKGYGKMLLDYASDWA RKAGLGFVSLSSGLQRKDAHRFYTDKMGFTIESYLFRKPV*" /label="yhdJ CDS" gene 951999..952427 /gene="yhdJ" /locus_tag="BSU_09490" /old_locus_tag="BSU09490" /label="yhdJ gene" downshifts 952406 /Source="Nicolas_upshifts" /id="D498" /incds=0 /nref=46 /ntot=213 /MaxReadThrough="1.42962" /MaxDrop="4.77191" /score="24.6412105" /energy="-12.1" /TU="NA" /idTUdmin="U752" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(952458..952748) /gene="asiMB" /locus_tag="BSU_09500" /old_locus_tag="BSU09500" /experiment="publication(s) with functional evidences, PMID:10216858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216858; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of the activity of sigma-M" /protein_id="NP_388831.1" /db_xref="EnsemblGenomes-Gn:BSU09500" /db_xref="EnsemblGenomes-Tr:CAB12789" /db_xref="GOA:O07580" /db_xref="InterPro:IPR020496" /db_xref="SubtiList:BG13017" /db_xref="UniProtKB/Swiss-Prot:O07580" /translation="MELVRIFKEHNVFGWISVGTAVLSLLLLNLAIISNVTFYSYQML PFAMAAVPFGVVELFIKRGRTGPGLLGVILNLFVIICVYTIVSVDTNLQFGF*" /label="asiMB CDS" gene complement(952458..952748) /gene="asiMB" /locus_tag="BSU_09500" /old_locus_tag="BSU09500" /label="asiMB gene" downshifts complement(952482) /Source="Nicolas_upshifts" /id="D499" /incds=0 /nref=44 /ntot=229 /MaxReadThrough="2.66153" /MaxDrop="4.72865" /score="26.7359231" /energy="-11.1" /TU="NA" /idTUdmin="U754" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(952736..953812) /gene="asiMA" /locus_tag="BSU_09510" /old_locus_tag="BSU09510" /experiment="publication(s) with functional evidences, PMID:10216858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216858; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of the activity of sigma-M" /protein_id="NP_388832.1" /db_xref="EnsemblGenomes-Gn:BSU09510" /db_xref="EnsemblGenomes-Tr:CAB12790" /db_xref="GOA:O07581" /db_xref="InterPro:IPR025672" /db_xref="InterPro:IPR029101" /db_xref="SubtiList:BG13018" /db_xref="UniProtKB/Swiss-Prot:O07581" /translation="MMNEEFKKRFDQYKNGEMSDQEMTAFEEELEKLEVYQELIDSEL EDDNDWDLSISPEKQKAILAYGKRKSYLRISVLAVISTLMILPLCTLGSYLYYGMGGK HSTGNEFMETAAVTVALTMPNVLVDTSGLKSQVKLFGMNTEFPLQKQIGTKTAAVGNE RVEMFYNKVKAPAVNYYDLEVNKTGHYFTHPSNKSEQTTAKAEKTLSTLPEGTVSEVY LSYDRAYPTKDVYNKFKGYDVSFLWNAIETEKNTNKTASTEPLGYPGKDSKFLAALNT KGKSNGDQFINALKFMSKHEKWAQVISKRKDLNVDNRLDYVEKNGVNVYGSVVTGPTK EIQRMLKNKSVKSANVGEVELWNW*" /label="asiMA CDS" gene complement(952736..953812) /gene="asiMA" /locus_tag="BSU_09510" /old_locus_tag="BSU09510" /label="asiMA gene" CDS complement(953802..954293) /gene="sigM" /locus_tag="BSU_09520" /old_locus_tag="BSU09520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14651641, 14769884" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14651641, 14769884; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF (extracytoplasmic function)-type sigma factor (sigma(M))" /protein_id="NP_388833.1" /db_xref="EnsemblGenomes-Gn:BSU09520" /db_xref="EnsemblGenomes-Tr:CAB12791" /db_xref="GOA:O07582" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014296" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13019" /db_xref="UniProtKB/Swiss-Prot:O07582" /translation="MTIDEIYQMYMNDVYRFLLSMTKDKHLAEDLLQETFMRAYIHIH SYDHSKVKPWLFQVARNAFIDYVRKHKKEVTISDDLIGSLFQNAVQSPAHQVEIKEVL TGYMSELPDNYREALTLYYLKELNYKEASHIMNISEANFKSVLFRARQRLKALYNRGV NDE*" /label="sigM CDS" gene complement(953802..954293) /gene="sigM" /locus_tag="BSU_09520" /old_locus_tag="BSU09520" /label="sigM gene" S_feature complement(954294..954396) /Source="Nicolas_S_feature" /locus_tag="new_1030069_1030171_c" /HighExp="Cold, LBGstat, H2O2, G180, Paraq, Oxctl, G135, HPh, dia15, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S330" promotor_-10 complement(954385..954404) /Source="Nicolas_upshift_promotors" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(954396) /Source="Nicolas_upshifts" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(954418..954421) /Source="Nicolas_upshift_promotors" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 954434..954440 /Source="Nicolas_upshift_promotors" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 954451 /Source="Nicolas_upshifts" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 954455..954473 /Source="Nicolas_upshift_promotors" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(954484) /Source="Nicolas_upshifts" /id="D500" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="2.13683" /MaxDrop="4.59517" /score="8.96845329" /energy="-10.2" /TU="NA" /idTUdmin="U757" /TUdmin=1804 /isTUend="FALSE" /label="downshifts" CDS 954490..955485 /gene="akrN" /locus_tag="BSU_09530" /old_locus_tag="BSU09530" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10220166, 15019785, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 15019785, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aldo/keto reductase specific for NADPH; protectsagainst methylglyoxal" /protein_id="NP_388834.1" /db_xref="EnsemblGenomes-Gn:BSU09530" /db_xref="EnsemblGenomes-Tr:CAB12792" /db_xref="GOA:P80874" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:1PZ1" /db_xref="SubtiList:BG13020" /db_xref="UniProtKB/Swiss-Prot:P80874" /translation="MEYTSIADTGIEASRIGLGTWAIGGTMWGGTDEKTSIETIRAAL DQGITLIDTAPAYGFGQSEEIVGKAIKEYGKRDQVILATKTALDWKNNQLFRHANRAR IVEEVENSLKRLQTDYIDLYQVHWPDPLVPIEETAEVMKELYDAGKIRAIGVSNFSIE QMDTFRAVAPLHTIQPPYNLFEREMEESVLPYAKDNKITTLLYGSLCRGLLTGKMTEE YTFEGDDLRNHDPKFQKPRFKEYLSAVNQLDKLAKTRYGKSVIHLAVRWILDQPGADI ALWGARKPGQLEALSEITGWTLNSEDQKDINTILENTISDPVGPEFMAPPTREEI*" /label="akrN CDS" gene 954490..955485 /gene="akrN" /locus_tag="BSU_09530" /old_locus_tag="BSU09530" /label="akrN gene" downshifts 955464 /Source="Nicolas_upshifts" /id="D501" /incds=0 /nref=59 /ntot=160 /MaxReadThrough="6.85446" /MaxDrop="4.90106" /score="10.4379759" /energy="-11.8" /TU="U755" /idTUdmin="U756" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-35 955547..955550 /Source="Nicolas_upshift_promotors" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 955565..955584 /Source="Nicolas_upshift_promotors" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 955570 /Source="Nicolas_upshifts" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="upshifts" CDS 955620..956219 /gene="plsC" /locus_tag="BSU_09540" /old_locus_tag="BSU09540" /EC_number="2.3.1.51" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1557036, 17557823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1557036, 17557823; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-acylglycerol-phosphate (1-acyl-G3P) acyltransferase" /protein_id="NP_388835.1" /db_xref="EnsemblGenomes-Gn:BSU09540" /db_xref="EnsemblGenomes-Tr:CAB12793" /db_xref="GOA:O07584" /db_xref="InterPro:IPR002123" /db_xref="InterPro:IPR004552" /db_xref="SubtiList:BG13021" /db_xref="UniProtKB/Swiss-Prot:O07584" /translation="MYKFCANALKVILSLRGGVKVYNKENLPADSGFVIACTHSGWVD VITLGVGILPYQIHYMAKKELFQNKWIGSFLKKIHAFPVDRENPGPSSIKTPIKLLKE GEIVGIFPSGTRTSEDVPLKRGAVTIAQMGKAPLVPAAYQGPSSGKELFKKGKMKLII GEPLHQADFAHLPSKERLAAMTEALNQRIKELENKLDQL*" /label="plsC CDS" gene 955620..956219 /gene="plsC" /locus_tag="BSU_09540" /old_locus_tag="BSU09540" /label="plsC gene" downshifts 956234 /Source="Nicolas_upshifts" /id="D502" /incds=0 /nref=189 /ntot=245 /MaxReadThrough="6.36101" /MaxDrop="7.07164" /score="-7.3088084" /energy="-6.1" /TU="U755" /idTUdmin="U756" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 956279..958233 /Source="Nicolas_S_feature" /locus_tag="new_1032054_1034008" /HighExp="Cold, C30, S8, T-4.40H, Sw, Fru, S0, S7, HPh, G135" /AntisenseName="yhdP" /AntisenseCor="-0.46228251493795502" /AntisenseRegPval="-14.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S331" CDS complement(956288..957622) /gene="yhdP" /locus_tag="BSU_09550" /old_locus_tag="BSU09550" /function="16.1: Circulate" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 25182490; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative magnesium efflux pump" /protein_id="NP_388836.1" /db_xref="EnsemblGenomes-Gn:BSU09550" /db_xref="EnsemblGenomes-Tr:CAB12794" /db_xref="GOA:O07585" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG13022" /db_xref="UniProtKB/Swiss-Prot:O07585" /translation="MDIVNLILVAVLIALTAFFVASEFAIIRIRGSRIDQLIAEGNKA AIAVKKVTTHLDEYLSACQLGITLTSIGLGVLGESTIERLLHPLFVQMNVPGSLSHVI SFIFAYAIITFLHVVVGELAPKTVAIQKAEAVSMLFAKPLIWFYRIAFPFIWLLNNSA RLLTKAFGLETVSENELAHSEEELRIILSESYKSGEINQSEFKYVNKIFEFDDRLAKE IMIPRTEIVSLPHDIKISEMMDIIQIEKYTRYPVEEGDKDNIIGVINIKEVLTACISG EVSVDSTISQFVNPIIHVIESAPIQDLLVKMQKERVHMAILSDEYGGTAGLVTVEDII EEIVGEIRDEFDIDEISEIRKIGEGHYILDGKVLIDQVNDLLGIHLENEEVDTIGGWF LTQKYDVEKDDSIIEEGCEFIINEIDGHHVAYIEVKKLQEEELLETANQQEA*" /label="yhdP CDS" gene complement(956288..957622) /gene="yhdP" /locus_tag="BSU_09550" /old_locus_tag="BSU09550" /label="yhdP gene" downshifts complement(956307) /Source="Nicolas_upshifts" /id="D503" /incds=0 /nref=284 /ntot=315 /MaxReadThrough="1.96991" /MaxDrop="7.22379" /score="11.1466394" /energy="-9.1" /TU="NA" /idTUdmin="U757" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" CDS complement(957683..958114) /gene="cueR" /locus_tag="BSU_09560" /old_locus_tag="BSU09560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075, 18048925" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 18048925; Product type r: regulator" /codon_start=1 /transl_table=11 /product="indirect copper efflux transcriptional regulator" /protein_id="NP_388837.1" /db_xref="EnsemblGenomes-Gn:BSU09560" /db_xref="EnsemblGenomes-Tr:CAB12795" /db_xref="GOA:O07586" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG13023" /db_xref="UniProtKB/Swiss-Prot:O07586" /translation="MVGRDIDGAETYRISELAALAGVTKRTVDYYTNLGLLTPARSCS NYRYYDENALKRLIFIVDCKKQRLALSDIKDRLENQFPSSAKLDDEIGNLALEIDHMN QNISGILHRFERLKPEDRDKLKSKLPPEKLAVFQSFMLLLS*" /label="cueR CDS" gene complement(957683..958114) /gene="cueR" /locus_tag="BSU_09560" /old_locus_tag="BSU09560" /label="cueR gene" promotor_-10 complement(958126..958145) /Source="Nicolas_upshift_promotors" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(958136) /Source="Nicolas_upshifts" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(958160..958166) /Source="Nicolas_upshift_promotors" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box complement(958162..958262) /Source="Nicolas_upshift_promotors" /id="U758" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.708291708291708" /psig="0.006993006993007" /xcortree=284 /SigmaFactorBS="tccgcatataaaaatttgaaaattctatcttcctatgttact tcaatcagatgatgaattccacaacttccaattccggtctaaaaaaaacaataaactt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-35 958197..958204 /Source="Nicolas_upshift_promotors" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="promotor_-35" upshifts complement(958202) /Source="Nicolas_upshifts" /id="U758" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.708291708291708" /psig="0.006993006993007" /xcortree=284 /SigmaFactorBS="tccgcatataaaaatttgaaaattctatcttcctatgttact tcaatcagatgatgaattccacaacttccaattccggtctaaaaaaaacaataaactt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 958218..958237 /Source="Nicolas_upshift_promotors" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="promotor_-10" upshifts 958235 /Source="Nicolas_upshifts" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="upshifts" CDS 958271..959452 /gene="yhdR" /locus_tag="BSU_09570" /old_locus_tag="BSU09570" /EC_number="2.6.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12670965, 15103638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aspartate aminotransferase" /protein_id="NP_388838.1" /db_xref="EnsemblGenomes-Gn:BSU09570" /db_xref="EnsemblGenomes-Tr:CAB12796" /db_xref="GOA:O07587" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13024" /db_xref="UniProtKB/Swiss-Prot:O07587" /translation="MKLAGLSREVEENLNKGSWIRKLFDEGARLKKEFGEDQVFDFSL GNPIVEPPEAFKRALIEEAEKGSHGYIQNQGLLAAREKVAQFLGSRFEADFSAERIVM TVGAGGALNVALKSIVNPGEEVIILAPYFAEYKLYIENYGGKAVSCPLTSRFEIDIEA VRQSITPQTKGLILNTPHNPTGTVLSQKNIDDLGALLKEIEEKSGQTIYVLFDEPYSQ LIYDEELANPFQSYHRVILASSFSKDLGIAGERLGYIGLDSRMPDADLLINAFVYCNR TLGFVNAPVMMQRAVARMDDLRVDASAYKERRDLMVDILKEAGFEFEMPKGGFFVFPK SPIEDEVAFCVHAAQKYKLLIVPSSGFGMSGHFRLSFSVPIEQIKNSRDIFISLYKDF A*" /label="yhdR CDS" gene 958271..959452 /gene="yhdR" /locus_tag="BSU_09570" /old_locus_tag="BSU09570" /label="yhdR gene" downshifts 959437 /Source="Nicolas_upshifts" /id="D504" /incds=0 /nref=12 /ntot=180 /MaxReadThrough="2.81766" /MaxDrop="3.37889" /score="-5.8634451" /energy="-9.1" /TU="U759" /idTUdmin="U759" /TUdmin="-163" /isTUend="FALSE" /label="downshifts" S_feature 959482..959620 /Source="Nicolas_S_feature" /locus_tag="new_1035257_1035395" /HighExp="Etha, S1, BMM, S2, Cold, MG 45, MG 25, C90, T-5.40H, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S332" misc_feature 959616..959635 /Source="Nicolas_upshift_promotors" /id="U760" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.771228771228771" /psig="0.999000999001" /xcortree=460 /SigmaFactorBS="aaggctttcttcatgataaaagtctaaaaattaaaaatcatt tttggaatgagtTGTGTTACAATAAAATATACaatttataatcaaactttgacttttg g" /listShort="S333, yhdT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 959622..959778 /Source="Nicolas_S_feature" /locus_tag="new_1035397_1035553" /HighExp="M9-stat, B60, T4.0H, T3.0H, LoTm, S5, T5.0H, S4, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S333" upshifts 959622 /Source="Nicolas_upshifts" /id="U760" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.771228771228771" /psig="0.999000999001" /xcortree=460 /SigmaFactorBS="aaggctttcttcatgataaaagtctaaaaattaaaaatcatt tttggaatgagtTGTGTTACAATAAAATATACaatttataatcaaactttgacttttg g" /listShort="S333, yhdT" /GFF_Attribute="listLong" /label="upshifts" CDS 959779..961164 /gene="yhdT" /locus_tag="BSU_09590" /old_locus_tag="BSU09590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388840.1" /db_xref="EnsemblGenomes-Gn:BSU09590" /db_xref="EnsemblGenomes-Tr:CAB12798" /db_xref="GOA:O07589" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG13026" /db_xref="UniProtKB/Swiss-Prot:O07589" /translation="MDDIDSLILIGVLIALTAFFVASEFAIVRVRRSRIDQLITEGNK RAILARRVITDLDEYLSASQLGITLTSIGLGVLGEPAFERLLHPLFEPLGLPDSVSHA VSFAVAYGLITFLHVVVGELAPKTVAIQKAEQLTLLIAGPLRLFYLLLFPFIWILNGS ARLLCGMFGLKPASEHDGSHSEEELRMLLSESLKNGEINPSEYKYVNKIFEFDNRIAK EIMIPRKEMAAVSTEMTMAEMLEVMLKEKYTRWPVTDGDKDSVLGLVNTKHLFSDLLF MTEEERMKMTIHPYVRPVIEVIETIPVHDLLIKMQRERIHMAILSDEYGGTSGLVTTE DILEEIVGEIRDEFDEDEQPLIQKLGDGHYVMDGKVRIDQVNSLLGASIQEDVDTIGG LILKENIDIEAGESIRIGSYTIKVLKMDGRLIKQIDIKEEAGNTTGITAHHKLPLPEP VMLNSATLSEK*" /label="yhdT CDS" gene 959779..961164 /gene="yhdT" /locus_tag="BSU_09590" /old_locus_tag="BSU09590" /label="yhdT gene" downshifts 961054 /Source="Nicolas_upshifts" /id="D505" /incds=1 /nref=120 /ntot=240 /MaxReadThrough="5.11037" /MaxDrop="3.79021" /score="19.6985636" /energy="-10.5" /TU="U760" /idTUdmin="U760" /TUdmin="-86" /isTUend="FALSE" /label="downshifts" downshifts 961140 /Source="Nicolas_upshifts" /id="D506" /incds=0 /nref=129 /ntot=245 /MaxReadThrough="1.68999" /MaxDrop="6.12682" /score="19.6985636" /energy="-10.5" /TU="NA" /idTUdmin="U760" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(961178..961534) /gene="crcBA" /locus_tag="BSU_09600" /old_locus_tag="BSU09600" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8844142, 12904550, 15849754, 16850406, 17196979, 22194412, 27824896; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fluoride efflux channel component A" /protein_id="NP_388841.1" /db_xref="EnsemblGenomes-Gn:BSU09600" /db_xref="EnsemblGenomes-Tr:CAB12799" /db_xref="GOA:O07590" /db_xref="InterPro:IPR003691" /db_xref="SubtiList:BG13027" /db_xref="UniProtKB/Swiss-Prot:O07590" /translation="MTLAGIFIGGGLGAMLRFWLGNVITAKTKGLSLPIGILTVNILG ALGLGIFTGLHVANASVSLIIGTGFFGAFTTFSTFSVETIQLLMAKRVKESILYIVLT LCGSLFAFWCGWTITI*" /label="crcBA CDS" gene complement(961178..961534) /gene="crcBA" /locus_tag="BSU_09600" /old_locus_tag="BSU09600" /label="crcBA gene" CDS complement(961531..961926) /gene="crcBB" /locus_tag="BSU_09610" /old_locus_tag="BSU09610" /function="16.1: Circulate" /function="16.4: Excrete" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8844142, 12904550, 15849754, 16850406, 22194412, 27824896; Product type t : transporter" /codon_start=1 /transl_table=11 /product="subunit of fluoride efflux transporter" /protein_id="NP_388842.1" /db_xref="EnsemblGenomes-Gn:BSU09610" /db_xref="EnsemblGenomes-Tr:CAB12800" /db_xref="GOA:O07591" /db_xref="InterPro:IPR003691" /db_xref="SubtiList:BG13028" /db_xref="UniProtKB/Swiss-Prot:O07591" /translation="MKIYSAVFIGGALGACLRYGLNLWIHTGQFPAATWLENAAGSLL LGILTGFFMIGAKRPLLSAFLGTGFCGGFTTMSTFSKETVMLLQGQPSLALLYVAASL ISGIIFALIGVFVGRRIAGIQQRKGLQEK*" /label="crcBB CDS" gene complement(961531..961926) /gene="crcBB" /locus_tag="BSU_09610" /old_locus_tag="BSU09610" /label="crcBB gene" CDS complement(961913..962644) /gene="yhdW" /locus_tag="BSU_09620" /old_locus_tag="BSU09620" /EC_number="3.1.4.46" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8012593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycerophosphodiester phosphodiesterase" /protein_id="NP_388843.1" /db_xref="EnsemblGenomes-Gn:BSU09620" /db_xref="EnsemblGenomes-Tr:CAB12801" /db_xref="GOA:O07592" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="SubtiList:BG13029" /db_xref="UniProtKB/Swiss-Prot:O07592" /translation="MYIIAHRGASGYAPENTIAAFDLAVKMNADMIELDVQLTKDRQI VVIHDDRVDRTTNGSGFVKDFTLEELQKLDAGSWYGPAFQGERIPTLEAVLKRYHKKI GLLIELKGHPSQVGIEEEVGQLLGQFSFSINNIVQSFQFRSVQRFRELYPSIPTAVIT RPNFGMLSRNQMKAFRSFANYVNIKHTRLNRLMIGSINKNGLNIFAWTVNNQKTAAKL QAMGVDGIVTDYPDFIIKDGKHENI*" /label="yhdW CDS" gene complement(961913..962644) /gene="yhdW" /locus_tag="BSU_09620" /old_locus_tag="BSU09620" /label="yhdW gene" misc_feature complement(962669..962688) /Source="Nicolas_upshift_promotors" /id="U761" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.683316683316683" /psig="0.986013986013986" /xcortree=3010 /SigmaFactorBS="gcccggaccattccgatatggcagaaaaaattcaccagtttg tatcgcggtgcatatatggaTTTGATACAATAACAGAAATgcccatacgaggagctga c" /listShort="yhdW, yhdV, crcBA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(962690) /Source="Nicolas_upshifts" /id="U761" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.683316683316683" /psig="0.986013986013986" /xcortree=3010 /SigmaFactorBS="gcccggaccattccgatatggcagaaaaaattcaccagtttg tatcgcggtgcatatatggaTTTGATACAATAACAGAAATgcccatacgaggagctga c" /listShort="yhdW, yhdV, crcBA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 962737..962745 /Source="Nicolas_upshift_promotors" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 962754 /Source="Nicolas_upshifts" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 962759..962774 /Source="Nicolas_upshift_promotors" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 962768..962841 /Source="Nicolas_S_feature" /locus_tag="new_1038543_1038616" /HighExp="S5, S4, S6, S7, S8, S3, B60, Pyr, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.563" /TUlongSig="NA" /TUlongPSig="NA" /label="S334" promotor_-35 962828..962829 /Source="Nicolas_upshift_promotors" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 962843 /Source="Nicolas_upshifts" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 962845..962864 /Source="Nicolas_upshift_promotors" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="promotor_-10" CDS 962878..962985 /gene="yhdX" /locus_tag="BSU_09630" /old_locus_tag="BSU09630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388844.1" /db_xref="EnsemblGenomes-Gn:BSU09630" /db_xref="EnsemblGenomes-Tr:CAB12802" /db_xref="InterPro:IPR035384" /db_xref="SubtiList:BG13030" /db_xref="UniProtKB/Swiss-Prot:O07593" /translation="MGKGRIRVEERIKAETDAEMQKATLLDQTQTKKGK*" /label="yhdX CDS" gene 962878..962985 /gene="yhdX" /locus_tag="BSU_09630" /old_locus_tag="BSU09630" /label="yhdX gene" S_feature 962986..963039 /Source="Nicolas_S_feature" /locus_tag="new_1038761_1038814" /HighExp="Sw, BC, LPhT, HiOs, S4, HiTm, S5, B36, S7, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S335" downshifts 963010 /Source="Nicolas_upshifts" /id="D507" /incds=0 /nref=177 /ntot=225 /MaxReadThrough="0.97838" /MaxDrop="7.47175" /score="21.9742676" /energy="-14.5" /TU="NA" /idTUdmin="U762" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 963090..963109 /Source="Nicolas_upshift_promotors" /id="U764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.381618381618382" /psig="0.931068931068931" /xcortree=1800 /SigmaFactorBS="tttcgccggggttttgtgctgcataagacatttaaatgaaca tccttacgaataTTTTAGTATAATAAACAATTgattgggatagaggggagacagtcat g" /listShort="yhdY, yhdZ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 963096 /Source="Nicolas_upshifts" /id="U764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.381618381618382" /psig="0.931068931068931" /xcortree=1800 /SigmaFactorBS="tttcgccggggttttgtgctgcataagacatttaaatgaaca tccttacgaataTTTTAGTATAATAAACAATTgattgggatagaggggagacagtcat g" /listShort="yhdY, yhdZ" /GFF_Attribute="listLong" /label="upshifts" CDS 963134..964249 /gene="mscY" /locus_tag="BSU_09640" /old_locus_tag="BSU09640" /function="16.8: Protect" /function="16.12: Sense" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12077558, 15849754, 16850406, 17665170, 18310427, 19252899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12077558, 15849754, 16850406, 17665170, 18310427, 19252899; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small conductance mechano-sensitive channel" /protein_id="NP_388845.1" /db_xref="EnsemblGenomes-Gn:BSU09640" /db_xref="EnsemblGenomes-Tr:CAB12803" /db_xref="GOA:O07594" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR006686" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="InterPro:IPR011066" /db_xref="SubtiList:BG13031" /db_xref="UniProtKB/Swiss-Prot:O07594" /translation="MPDYLQQYFTLDNIIQIGISLAILLVFLILRKLFTRYFFNLLFN LTNRPKTEIFKQVVLAFDKPARWFFVALGLFLAIRYSPFLDEQMPVISKIYRSLIVAL LCWGLCNLTATSSFIFHKVNQRFELDMDDILAPFLSKLLRFVIIALSVSVIAQEFNYD VNGFVAGLGLGGLAFALAAKDTISNFFGGIIIITEKPFTIGDWVETSTVTGSVEDITF RSTRFRTAQGALVTVPNSTLSMEAITNWTRMTKRQITFSIHVSYATPIENLERSIHSL RTMLLEHEGVDNEIIMVNFDTFADSYYNLFFNFYTKTTVWAENLNIREDINYKIIEIL GAEGVQFAYPGQMVVVKQKHESDQFQVNLNKEEKERA*" /label="mscY CDS" gene 963134..964249 /gene="mscY" /locus_tag="BSU_09640" /old_locus_tag="BSU09640" /label="mscY gene" downshifts 964229 /Source="Nicolas_upshifts" /id="D508" /incds=0 /nref=5 /ntot=141 /MaxReadThrough="3.45709" /MaxDrop="3.93891" /score="2.31392404" /energy="-12.3" /TU="U764" /idTUdmin="U764" /TUdmin="-783" /isTUend="FALSE" /label="downshifts" misc_feature 964286..964305 /Source="Nicolas_upshift_promotors" /id="U765" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig=1 /xcortree=3140 /SigmaFactorBS="aaagaggaaaaggaacgggcttaaaagagagacttcgtctga cagaggcggagtctttttCATGGTAAAATAAGAGAAAAaggcggtgttgagttggaaa c" /listShort="yhdZ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 964286 /Source="Nicolas_upshifts" /id="U765" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig=1 /xcortree=3140 /SigmaFactorBS="aaagaggaaaaggaacgggcttaaaagagagacttcgtctga cagaggcggagtctttttCATGGTAAAATAAGAGAAAAaggcggtgttgagttggaaa c" /listShort="yhdZ" /GFF_Attribute="listLong" /label="upshifts" CDS 964319..965062 /gene="srtN" /locus_tag="BSU_09650" /old_locus_tag="BSU09650" /EC_number="3.5.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16768447, 19136592, 26708127, 27987242" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16768447, 19136592, 26708127, 27987242; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sirtuin NAD-dependent deacetylase" /protein_id="NP_388846.1" /db_xref="EnsemblGenomes-Gn:BSU09650" /db_xref="EnsemblGenomes-Tr:CAB12804" /db_xref="GOA:O07595" /db_xref="InterPro:IPR003000" /db_xref="InterPro:IPR026590" /db_xref="InterPro:IPR028628" /db_xref="InterPro:IPR029035" /db_xref="SubtiList:BG13032" /db_xref="UniProtKB/Swiss-Prot:O07595" /translation="METFKSILHEAQRIVVLTGAGMSTESGIPDFRSAGGIWTEDASR MEAMSLDYFLSYPRLFWPKFKELFQMKMSGSFEPNEGHLLLAELEKQGKQVDIFTQNI DGLHKKAGSRHVYELHGSIQTAACPACGARYDLPHLLEREVPECTAAGNNGDICGTVL KTDVVLFGDAVMHFDTLYEKLDQADLLLVIGTSLEVAPARFVPEDASLIPGMKKVIIN LEPTYCDSLFDMVIHQKIGEFARSLGMKK*" /label="srtN CDS" gene 964319..965062 /gene="srtN" /locus_tag="BSU_09650" /old_locus_tag="BSU09650" /label="srtN gene" downshifts 965034 /Source="Nicolas_upshifts" /id="D509" /incds=0 /nref=3 /ntot=82 /MaxReadThrough="1.93149" /MaxDrop="2.85561" /score="9.76884826" /energy="-9.2" /TU="NA" /idTUdmin="U765" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(965086..965934) /gene="yheN" /locus_tag="BSU_09660" /old_locus_tag="BSU09660" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative polysaccharide deacetylase" /protein_id="NP_388847.1" /db_xref="EnsemblGenomes-Gn:BSU09660" /db_xref="EnsemblGenomes-Tr:CAB12805" /db_xref="GOA:O07596" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG13046" /db_xref="UniProtKB/Swiss-Prot:O07596" /translation="MRQTRGEASPSAVSLAFKFASLAVLCVLLLLMVILGYSNSSTKA KEVTVTTNGQLRDEKESLKLKNDSPDLLIKHLQTKQNMGDKTVYLTFDDGPSAVTTRL LDVLKSADVKATFFMLSPRMNEFKQAVKRAEKEGHALGLHGVTHNNRLFYQTPTSPLK EMQEARDTLQDITGYKTDLVRTPYGSKPSLTASQIRNLEKDGFVYWDWTIDSMDWKYR NSQYVTAVLQQLENMEHSSSSRPNVILMHDLPATVNALPVLINKLKEKGYSFGVLEDT MVPVHE*" /label="yheN CDS" gene complement(965086..965934) /gene="yheN" /locus_tag="BSU_09660" /old_locus_tag="BSU09660" /label="yheN gene" downshifts complement(965110) /Source="Nicolas_upshifts" /id="D510" /incds=0 /nref=126 /ntot=242 /MaxReadThrough="2.03966" /MaxDrop="4.72968" /score="-7.82934513" /energy="-9.2" /TU="NA" /idTUdmin="U767" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 965930..965935 /Source="Nicolas_upshift_promotors" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(965935..966034) /Source="Nicolas_S_feature" /locus_tag="new_1041710_1041809_c" /HighExp="Cold, T3.0H, T2.30H, T3.30H, T4.0H, T2.0H, HPh, C30, T1.30H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S336" promotor_-10 965951..965969 /Source="Nicolas_upshift_promotors" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 965953 /Source="Nicolas_upshifts" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="upshifts" S_feature 965958..966153 /Source="Nicolas_S_feature" /locus_tag="new_1041733_1041928" /HighExp="S5, S4, S6, S3, S7, S8, LoTm, B36, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S337" promotor_-10 complement(966023..966042) /Source="Nicolas_upshift_promotors" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(966037) /Source="Nicolas_upshifts" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(966057..966060) /Source="Nicolas_upshift_promotors" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 966152..966171 /Source="Nicolas_upshift_promotors" /id="U768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2940 /SigmaFactorBS="aaataaactcctttccgctatagatctcttgatctttctgtt tttcagcttgtccaaTATGGTAGAATTAGTGATAAtgacagcttgaatgacatcaggg a" /listShort="S338, dat" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 966155..966218 /Source="Nicolas_S_feature" /locus_tag="new_1041930_1041993" /HighExp="BC, T2.30H, T3.0H, T3.30H, T4.0H, T5.0H, T2.0H, T1.30H, S4, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S338" upshifts 966155 /Source="Nicolas_upshifts" /id="U768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2940 /SigmaFactorBS="aaataaactcctttccgctatagatctcttgatctttctgtt tttcagcttgtccaaTATGGTAGAATTAGTGATAAtgacagcttgaatgacatcaggg a" /listShort="S338, dat" /GFF_Attribute="listLong" /label="upshifts" CDS 966219..967067 /gene="dat" /locus_tag="BSU_09670" /old_locus_tag="BSU09670" /EC_number="2.6.1.21" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9003455, 17005988; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine aminotransferase" /protein_id="NP_388848.1" /db_xref="EnsemblGenomes-Gn:BSU09670" /db_xref="EnsemblGenomes-Tr:CAB12806" /db_xref="GOA:O07597" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005784" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG13045" /db_xref="UniProtKB/Swiss-Prot:O07597" /translation="MKVLVNGRLIGRSEASIDLEDRGYQFGDGIYEVIRVYKGVLFGL REHAERFFRSAAEIGISLPFSIEDLEWDLQKLVQENAVSEGAVYIQTTRGVAPRKHQY EAGLEPQTTAYTFTVKKPEQEQAYGVAAITDEDLRWLRCDIKSLNLLYNVMTKQRAYE AGAFEAILLRDGVVTEGTSSNVYAVINGTVRTHPANRLILNGITRMNILGLIEKNGIK LDETPVSEEELKQAEEIFISSTTAEIIPVVTLDGQSIGSGKPGPVTKQLQAAFQESIQ QAASIS*" /label="dat CDS" gene 966219..967067 /gene="dat" /locus_tag="BSU_09670" /old_locus_tag="BSU09670" /label="dat gene" downshifts 967058 /Source="Nicolas_upshifts" /id="D511" /incds=0 /nref=232 /ntot=261 /MaxReadThrough="2.27201" /MaxDrop="6.88888" /score="21.6239924" /energy="-11.5" /TU="U768" /idTUdmin="U766" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(967110..968471) /gene="nhaC" /locus_tag="BSU_09680" /old_locus_tag="BSU09680" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735849, 11274110, 15849754, 16850406, 17937670" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735849, 11274110, 15849754, 16850406, 17937670; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter" /protein_id="NP_388849.1" /db_xref="EnsemblGenomes-Gn:BSU09680" /db_xref="EnsemblGenomes-Tr:CAB12807" /db_xref="GOA:O07553" /db_xref="InterPro:IPR004770" /db_xref="InterPro:IPR018461" /db_xref="SubtiList:BG13044" /db_xref="UniProtKB/Swiss-Prot:O07553" /translation="MDSQKKLTFPLAVGLFIFMLCIIISCLFLLHVEPHIPLFLSVVM LSAAALWFGFPWKSIEKGIVDGIKNGVQPIIVLALIGILIGAWMYSGAIPTMTVYALS FIEPSHLLLTALFSCMIISTLVGSSLTTVSTIGVALIGVASAAGVPLEWTAGAVICGA CFGDKMSPMSDTTNFAAGIGEIPIFEHIRHMMGTTIPALLITVVLFYFLGSSVSADAA STDNIQQVITGIKDAANVTPWALLSPLLVVLLAMKRVSVIPVLTAGIISSGILTAIFV PYSSLQAFMTALQNGTTFETDNEAAAKIINRGGLQSMMGSVSLIMIAFALGGLMEKIG LISALLEGVMKGIRSKGRLVAATVCSSIGVNLATGEQYLSILIPGQSFKSLYDKRNIQ RKFLTRSLEDGGTLINPLIPWGVSGAFMASALGVPVIDYIPFTFFLYISPMISILIGF VKK*" /label="nhaC CDS" gene complement(967110..968471) /gene="nhaC" /locus_tag="BSU_09680" /old_locus_tag="BSU09680" /label="nhaC gene" downshifts complement(967134) /Source="Nicolas_upshifts" /id="D512" /incds=0 /nref=7 /ntot=77 /MaxReadThrough="0.50034" /MaxDrop="3.60175" /score="1.04025421" /energy="-11.5" /TU="NA" /idTUdmin="U769" /TUdmin=22 /isTUend="TRUE" /label="downshifts" S_feature complement(968472..968542) /Source="Nicolas_S_feature" /locus_tag="new_1044247_1044317_c" /HighExp="B60, G135, Etha, LBGexp, G150, Diami, Paraq, G180, H2O2, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.96, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S339" misc_feature complement(968515..968534) /Source="Nicolas_upshift_promotors" /id="U769" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.926073926073926" /psig="0.96003996003996" /xcortree=2470 /SigmaFactorBS="agtgagcacgccctgtgctcacttcttttatattcataattg tgaaaaaacatagattttcgttttttTCTGTTATAATGCTTTCGTGcccaaaagcaca a" /listShort="S339, nhaC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(968542) /Source="Nicolas_upshifts" /id="U769" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.926073926073926" /psig="0.96003996003996" /xcortree=2470 /SigmaFactorBS="agtgagcacgccctgtgctcacttcttttatattcataattg tgaaaaaacatagattttcgttttttTCTGTTATAATGCTTTCGTGcccaaaagcaca a" /listShort="S339, nhaC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(968598..969098) /gene="nhaX" /locus_tag="BSU_09690" /old_locus_tag="BSU09690" /function="16.12: Sense" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11988534, 16159758, 27464829; Product type f: factor" /codon_start=1 /transl_table=11 /product="stress response protein, UspA family" /protein_id="NP_388850.2" /db_xref="EnsemblGenomes-Gn:BSU09690" /db_xref="EnsemblGenomes-Tr:CAB12808" /db_xref="GOA:O07552" /db_xref="InterPro:IPR006015" /db_xref="InterPro:IPR006016" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13043" /db_xref="UniProtKB/Swiss-Prot:O07552" /translation="MFHADRIIVAFDGSENSKKALLTAIDLAKTVNAAITVAHSHDMK DNQTVIDPPRPAAEASYISGGMTSVPDPLISDVTSPEPMIYEDRTEEVIAEARMMLNE QQADGDIDILEGDPAESIIEHANRISADMIVTGSRDQNRLKKLIFGSVSEKLSAKSDI PVLIVK*" /label="nhaX CDS" gene complement(968598..969098) /gene="nhaX" /locus_tag="BSU_09690" /old_locus_tag="BSU09690" /label="nhaX gene" downshifts complement(968630) /Source="Nicolas_upshifts" /id="D513" /incds=0 /nref=10 /ntot=63 /MaxReadThrough="4.74071" /MaxDrop="5.69273" /score="4.44189378" /energy="-12.2" /TU="U770" /idTUdmin="U770" /TUdmin="-1320" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(969120..969138) /Source="Nicolas_upshift_promotors" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(969140) /Source="Nicolas_upshifts" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(969153..969159) /Source="Nicolas_upshift_promotors" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 969177..969184 /Source="Nicolas_upshift_promotors" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 969192..969261 /Source="Nicolas_S_feature" /locus_tag="new_1044967_1045036" /HighExp="C90, M9-stat, BC, T1.30H, T3.30H, Sw, T5.0H, GM 15, T3.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S340" upshifts 969193 /Source="Nicolas_upshifts" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 969199..969218 /Source="Nicolas_upshift_promotors" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 969262..969423 /gene="bmrB" /locus_tag="BSU_09700" /old_locus_tag="BSU09700" /experiment="publication(s) with functional evidences, PMID:25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25217586; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator leader peptide" /protein_id="NP_388851.1" /db_xref="EnsemblGenomes-Gn:BSU09700" /db_xref="EnsemblGenomes-Tr:CAB12809" /db_xref="SubtiList:BG13042" /db_xref="UniProtKB/Swiss-Prot:O07551" /translation="MFIKQFHIGAANLLFCFRERFFRSDRALKSAVRNISVKKGMELT LHAFFIYKI*" /label="bmrB CDS" gene 969262..969423 /gene="bmrB" /locus_tag="BSU_09700" /old_locus_tag="BSU09700" /label="bmrB gene" downshifts 969353 /Source="Nicolas_upshifts" /id="D514" /incds=1 /nref=29 /ntot=180 /MaxReadThrough="5.31538" /MaxDrop="4.59672" /score="25.6910195" /energy="-14.4" /TU="U771" /idTUdmin="U768" /TUdmin=2273 /isTUend="FALSE" /label="downshifts" S_feature 969424..969542 /Source="Nicolas_S_feature" /locus_tag="new_1045199_1045317" /HighExp="LPhT, S7, S6, T-1.10H, Sw, LBGstat, S5, T-0.40H, S8, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S341" CDS 969543..971300 /gene="bmrC" /locus_tag="BSU_09710" /old_locus_tag="BSU09710" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15855514, 16487324, 19167342, 21602923, 25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15855514, 16487324, 19167342, 21602923, 25217586; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux ABC transporter (ATP-binding protein)" /protein_id="NP_388852.1" /db_xref="EnsemblGenomes-Gn:BSU09710" /db_xref="EnsemblGenomes-Tr:CAB12810" /db_xref="GOA:O07550" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13041" /db_xref="UniProtKB/Swiss-Prot:O07550" /translation="MFSVLKKLGWFFKAYWLRYTIAIVLLLAVNVIEMFPPKLLGNAI DDMKAGAFTAEGLLFYIGIFFVLTAAVYIMSYFWMHQLFGGANLMEKILRTKLMGHLL TMSPPFYEKNRTGDLMARGTNDLQAVSLTTGFGILTLVDSTMFMMTIFLTMGFLISWK LTFAAIIPLPVMAIAISLYGSKIHERFTEAQNAFGALNDRVLESVSGVRVIRAYVQET NDVRRFNEMTADVYQKNMKVAFIDSLFEPTVKLLVGASYLIGLGYGAFLVFRNELTLG ELVSFNVYLGMMIWPMFAIGELINVMQRGNASLDRVNETLSYETDVTDPKQPADLKEP GDIVFSHVSFTYPSSTSDNLQDISFTVRKGQTVGIAGKTGSGKTTIIKQLLRQYPPGE GSITFSGVPIQQIPLDRLRGWIGYVPQDHLLFSRTVKENILYGKQDATDKEVQQAIAE AHFEKDLHMLPSGLETMVGEKGVALSGGQKQRISIARALMANPEILILDDSLSAVDAK TEAAIIKNIRENRKGKTTFILTHRLSAVEHADLILVMDGGVIAERGTHQELLANNGWY REQYERQQLFTAEEGGAGA*" /label="bmrC CDS" gene 969543..971300 /gene="bmrC" /locus_tag="BSU_09710" /old_locus_tag="BSU09710" /label="bmrC gene" CDS 971297..973318 /gene="bmrD" /locus_tag="BSU_09720" /old_locus_tag="BSU09720" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15855514, 16487324, 19167342, 21602923, 25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15855514, 16487324, 19167342, 21602923, 25217586; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux ABC transporter (ATP-binding subunit)" /protein_id="NP_388853.1" /db_xref="EnsemblGenomes-Gn:BSU09720" /db_xref="EnsemblGenomes-Tr:CAB12811" /db_xref="GOA:O07549" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13040" /db_xref="UniProtKB/Swiss-Prot:O07549" /translation="MKIGKTLWRYALLYRKLLITAVLLLTVAVGAELTGPFIGKKMID DHILGIEKTWYEAAEKDKNAVQFHGVSYVREDRLQEPVSKAKEAHIYQVGMAFYFVDQ AVSFDGNRTVSDGKLTITNGDKSRAYAAEKLTKQELFQFYQPEIKGMVLLICLYGGLL VFSVFFQYGQHYLLQMSANRIIQKMRQDVFSHIQKMPIRYFDNLPAGKVVARITNDTE AIRDLYVTVLSTFVTSGIYMFGIFTALFLLDVKLAFVCLAIVPIIWLWSVIYRRYASY YNQKIRSINSDINAKMNESIQGMTIIQAFRHQKETMREFEELNESHFYFQNRMLNLNS LMSHNLVNVIRNLAFVCLIWHFGGASLNAAGIVSIGVLYAFVDYLNRLFQPITGIVNQ FSKLELARVSAGRVFELLEEKNTEEAGEPAKERALGRVEFRDVSFAYQEGEEVLKHIS FTAQKGETVALVGHTGSGKSSILNLLFRFYDAQKGDVLIDGKSIYNMSRQELRSHMGI VLQDPYLFSGTIGSNVSLDDERMTEEEIKNALRQVGAEPLLKKLPKGINEPVIEKGST LSSGERQLISFARALAFDPAILILDEATAHIDTETEAVIQKALDVVKQGRTTFVIAHR LSTIRNADQILVLDKGEIVERGNHEELMALEGQYYQMYELQKGQKHSIA*" /label="bmrD CDS" gene 971297..973318 /gene="bmrD" /locus_tag="BSU_09720" /old_locus_tag="BSU09720" /label="bmrD gene" downshifts 973306 /Source="Nicolas_upshifts" /id="D515" /incds=0 /nref=69 /ntot=230 /MaxReadThrough="0.741399999999999" /MaxDrop="5.11492" /score="9.67206405" /energy="-10.9" /TU="NA" /idTUdmin="U771" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(973367..973987) /gene="yheG" /locus_tag="BSU_09730" /old_locus_tag="BSU09730" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH-flavin oxidoreductase" /protein_id="NP_388854.1" /db_xref="EnsemblGenomes-Gn:BSU09730" /db_xref="EnsemblGenomes-Tr:CAB12812" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13039" /db_xref="UniProtKB/Swiss-Prot:O07548" /translation="MKIALLGASGRVGQAFLTQAAADERFDIFALIRSQHADLPLSKD RTVMGNARRLEDVKKIMENAEIVISCLGTDGDDTLSTAMAHILSVMEEQHIKRLITIG TAGILDSRYEPGKYRFETNESKRKQTRAAKEHAKVYEMLKESSLDWTIICPTYLPDGT ATGVYRTERNVLPEGGTSISVGDTADFLYRELVTGEYVGNRVGLAY*" /label="yheG CDS" gene complement(973367..973987) /gene="yheG" /locus_tag="BSU_09730" /old_locus_tag="BSU09730" /label="yheG gene" downshifts complement(973382) /Source="Nicolas_upshifts" /id="D516" /incds=0 /nref=19 /ntot=169 /MaxReadThrough="1.82652" /MaxDrop="3.00293" /score="-0.293143554" /energy="-10.9" /TU="NA" /idTUdmin="U772" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box 973972..974072 /Source="Nicolas_upshift_promotors" /id="U773" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.45954045954046" /psig="0.043956043956044" /xcortree=770 /SigmaFactorBS="ataaagcgattttcattaaaaaacctcctcgcctttcattat aaaaggatgttctcagtttgaacagcgcgggaaagaatacctgtacaaataaacagaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(974001..974020) /Source="Nicolas_upshift_promotors" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(974016) /Source="Nicolas_upshifts" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="upshifts" CDS complement(974026..974151) /gene="yheF" /locus_tag="BSU_09740" /old_locus_tag="BSU09740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388855.1" /db_xref="EnsemblGenomes-Gn:BSU09740" /db_xref="EnsemblGenomes-Tr:CAB12813" /db_xref="SubtiList:BG13038" /db_xref="UniProtKB/Swiss-Prot:O07547" /translation="MSFITIVNWELVQFVSVSMIHEYVSHRSVYLYRYSFPRCSN*" /label="yheF CDS" gene complement(974026..974151) /gene="yheF" /locus_tag="BSU_09740" /old_locus_tag="BSU09740" /label="yheF gene" upshifts 974032 /Source="Nicolas_upshifts" /id="U773" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.45954045954046" /psig="0.043956043956044" /xcortree=770 /SigmaFactorBS="ataaagcgattttcattaaaaaacctcctcgcctttcattat aaaaggatgttctcagtttgaacagcgcgggaaagaatacctgtacaaataaacagaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(974035..974038) /Source="Nicolas_upshift_promotors" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(974165..974184) /Source="Nicolas_upshift_promotors" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(974174) /Source="Nicolas_upshifts" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(974198..974207) /Source="Nicolas_upshift_promotors" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 974230 /Source="Nicolas_upshifts" /id="D517" /incds=0 /nref=6 /ntot=22 /MaxReadThrough="0.352760000000001" /MaxDrop="4.67633" /score="9.67206405" /energy="-10.9" /TU="NA" /idTUdmin="U773" /TUdmin=88 /isTUend="FALSE" /label="downshifts" CDS complement(974256..974459) /gene="sspB" /locus_tag="BSU_09750" /old_locus_tag="BSU09750" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:3009398, 9572981, 16707666, 19659696, 26790838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3009398, 9572981, 16707666, 19659696, 26790838; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (beta-type SASP)" /protein_id="NP_388856.1" /db_xref="EnsemblGenomes-Gn:BSU09750" /db_xref="EnsemblGenomes-Tr:CAB12814" /db_xref="GOA:P04832" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10787" /db_xref="UniProtKB/Swiss-Prot:P04832" /translation="MANQNSSNDLLVPGAAQAIDQMKLEIASEFGVNLGADTTSRANG SVGGEITKRLVSFAQQQMGGRVQ*" /label="sspB CDS" gene complement(974256..974459) /gene="sspB" /locus_tag="BSU_09750" /old_locus_tag="BSU09750" /label="sspB gene" downshifts complement(974261) /Source="Nicolas_upshifts" /id="D518" /incds=0 /nref=72 /ntot=93 /MaxReadThrough="1.27819" /MaxDrop="8.55895" /score="22.2113888" /energy="-16" /TU="NA" /idTUdmin="U776" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(974460..974570) /Source="Nicolas_S_feature" /locus_tag="new_1050235_1050345_c" /HighExp="S8, S5, S7, S6, S4, G/S, Pyr, ferm, BT, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S342" promotor_no_box 974500..974600 /Source="Nicolas_upshift_promotors" /id="U775" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.665334665334665" /psig="0.090909090909091" /xcortree=696 /SigmaFactorBS="ggagttgcaccaatctgtgaacccttctcgggtgtcactgcc gcctcggcgtaacccaatgctttgccggcttgttactacgtattatgttaaaatggcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 974560 /Source="Nicolas_upshifts" /id="U775" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.665334665334665" /psig="0.090909090909091" /xcortree=696 /SigmaFactorBS="ggagttgcaccaatctgtgaacccttctcgggtgtcactgcc gcctcggcgtaacccaatgctttgccggcttgttactacgtattatgttaaaatggcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(974576) /Source="Nicolas_upshifts" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(974580..974591) /Source="Nicolas_upshift_promotors" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(974606..974612) /Source="Nicolas_upshift_promotors" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(974668..974886) /gene="yheE" /locus_tag="BSU_09760" /old_locus_tag="BSU09760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (sporulation / germination island)" /protein_id="NP_388857.1" /db_xref="EnsemblGenomes-Gn:BSU09760" /db_xref="EnsemblGenomes-Tr:CAB12815" /db_xref="InterPro:IPR017263" /db_xref="SubtiList:BG13037" /db_xref="UniProtKB/Swiss-Prot:O07546" /translation="MAVMISHFSWKPLFPKEKLPGWKISFYYKGTHYEGIYHKSGEIE WGDLFPARADEPALTNEIHELMLFHIYD*" /label="yheE CDS" gene complement(974668..974886) /gene="yheE" /locus_tag="BSU_09760" /old_locus_tag="BSU09760" /label="yheE gene" downshifts complement(974702) /Source="Nicolas_upshifts" /id="D519" /incds=0 /nref=5 /ntot=83 /MaxReadThrough="0.43384" /MaxDrop="3.42951" /score="37.4339943" /energy="-11.8" /TU="NA" /idTUdmin="U777" /TUdmin=110 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(974927..974946) /Source="Nicolas_upshift_promotors" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(974944) /Source="Nicolas_upshifts" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(974960..974967) /Source="Nicolas_upshift_promotors" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(975036..976397) /gene="spaD" /locus_tag="BSU_09770" /old_locus_tag="BSU09770" /function="16.5: Explore" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15231775, 25035995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231775, 25035995; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat associated protein" /protein_id="NP_388858.2" /db_xref="EnsemblGenomes-Gn:BSU09770" /db_xref="EnsemblGenomes-Tr:CAB12816" /db_xref="GOA:O07545" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR026838" /db_xref="SubtiList:BG13036" /db_xref="UniProtKB/Swiss-Prot:O07545" /translation="MNPKRFLIGIDKTSENTLFLPSSLKQDGLLHAAFGTKVVRCHVA YRRHLEQTVLLSENLFHELLLPHRSRADILIHDHTVHIGPLVGIFTAGFTVSLERPFK DRSLFFSKLVTLHEQAGGYCFVFGAHQINWEEGTIEGLLYRENGWEKKIVPLPNVVYD RLPNRKIEDSLLLQHTKKRLIDEYQIPWFNKTFFNKWNVHQLLEKDPRTAPFLPRSEL TPSVELIDELCGAYKKVYIKPANGALGTGIYQLTRTDGGLTVKHTNDAKTFTSIDYSD AASFLAEFQKHHNPSDFLIQQGVDLIEFQGKPADFRVHTNKNRKGKWTVTAIAVKISG KNSITTHLSNGGTVKTLAEVYDDPAERVEVIKKLSAAALTASHVLHDHIEGFIGEIGF DFGIDQNGKVWMFEANSRPGRSIFSHPNLHHVDSLTKRRSFEYASYLSEKAITSPEAL WPS*" /label="spaD CDS" gene complement(975036..976397) /gene="spaD" /locus_tag="BSU_09770" /old_locus_tag="BSU09770" /label="spaD gene" downshifts complement(975054) /Source="Nicolas_upshifts" /id="D520" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="2.33323" /MaxDrop="3.7968" /score="37.4339943" /energy="-11.8" /TU="NA" /idTUdmin="U779" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(975098) /Source="Nicolas_upshifts" /id="D521" /incds=1 /nref=2 /ntot=45 /MaxReadThrough="5.29177" /MaxDrop="3.36501" /score="37.4339943" /energy="-11.8" /TU="U779" /idTUdmin="U779" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(976387..977478) /gene="spaC" /locus_tag="BSU_09780" /old_locus_tag="BSU09780" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15231775, 25035995; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore coat associated protein, subunit C" /protein_id="NP_388859.1" /db_xref="EnsemblGenomes-Gn:BSU09780" /db_xref="EnsemblGenomes-Tr:CAB12817" /db_xref="GOA:O07544" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR026838" /db_xref="SubtiList:BG13035" /db_xref="UniProtKB/Swiss-Prot:O07544" /translation="MITLGFMSLSRQHEADYSAELAKRAPEFGIRFIRFTPFDISPDT LRVKASVYHSASSTWNETEMAIPDYIYDRCFYGKDSHSQKAKPIVEWLKKYPKTEFIG RGLPDKWTVLHDLQQHSVINPYIPETIKVSRYEQIHSFLSKEKACILKPAFGAGGRGV ILLKLGKKNITATYHIGKDKQTKTFSNQTSFKTWCKKVLQHQYLLQPYLNIQDKEQYP CDIRLFMEKNEAGEWNTVGKAVRRGYKHGLLANLSGGSDALTFDSWFEDIPKKQQVVL LDDVFSITQSVPYYLDERYGPLFELGLDICLAKDGRIWILDINSKPGRKSILRVSPEQ KEQLYTCPLKRCQYLFSEQSQKGVLPRES*" /label="spaC CDS" gene complement(976387..977478) /gene="spaC" /locus_tag="BSU_09780" /old_locus_tag="BSU09780" /label="spaC gene" promotor_-10 complement(976802..976816) /Source="Nicolas_upshift_promotors" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(976814) /Source="Nicolas_upshifts" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(976830..976838) /Source="Nicolas_upshift_promotors" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(977479..977584) /Source="Nicolas_S_feature" /locus_tag="new_1053254_1053359_c" /HighExp="S4, B36, S5, S6, S7, S8, B60, S3, T5.0H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S343" promotor_-10 complement(977568..977586) /Source="Nicolas_upshift_promotors" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(977588) /Source="Nicolas_upshifts" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(977602..977607) /Source="Nicolas_upshift_promotors" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 977650..977657 /Source="Nicolas_upshift_promotors" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 977672..977691 /Source="Nicolas_upshift_promotors" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 977683 /Source="Nicolas_upshifts" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="upshifts" CDS 977745..978878 /gene="yheB" /locus_tag="BSU_09790" /old_locus_tag="BSU09790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16684363" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388860.1" /db_xref="EnsemblGenomes-Gn:BSU09790" /db_xref="EnsemblGenomes-Tr:CAB12818" /db_xref="GOA:O07543" /db_xref="InterPro:IPR007383" /db_xref="InterPro:IPR016991" /db_xref="SubtiList:BG13034" /db_xref="UniProtKB/Swiss-Prot:O07543" /translation="MGIAGTFIFMIVIGAAIGAVTNHLAIQMLFRPYKAYYLFGKRVP FTPGLIPRRRDELAKQMGLMVVNHLLTPEGIKKRLVSDAAKTQALRVGEQLIQKLSLS EVTVKEALEKAGMKRPEKAADAWISSWTDDKLHELFRQYGDQSLKELVPIEVQEKLEE KIPMISGYILSRSVRYFESDEGKIRLGNMIDDFLKERGMLGSMVQLFLGNSSLADRVL PELLKFLRNEETNKLLSDLLKNEWGKLREYTFNEADEKWNAKALIFSLKRRVLQAFST APFFNNTIGTLTVRYESELTQQMLPALLDKLLEGISSNLESVLKRLRLEEIVKEQVDQ FPVERLEEMVLSISKKEFKMITYLGGLLGGIIGAIQALFVILF*" /label="yheB CDS" gene 977745..978878 /gene="yheB" /locus_tag="BSU_09790" /old_locus_tag="BSU09790" /label="yheB gene" S_feature 978879..978970 /Source="Nicolas_S_feature" /locus_tag="new_1054654_1054745" /HighExp="S4, S5, S6, BT, S3, S7, dia15, B36, G/S, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S344" CDS 978971..979324 /gene="yheA" /locus_tag="BSU_09800" /old_locus_tag="BSU09800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19429628, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388861.1" /db_xref="EnsemblGenomes-Gn:BSU09800" /db_xref="EnsemblGenomes-Tr:CAB12819" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR023378" /db_xref="PDB:2OEE" /db_xref="SubtiList:BG13033" /db_xref="UniProtKB/Swiss-Prot:O07542" /translation="MAVNFYDVAYDLENALRGSEEFTRLKNLYDEVNADESAKRMFEN FRDVQLRLQQKQMAGEEITQEEVTQAQKTVALVQQHEKISQLMEAEQRMSMLIGELNK IIMKPLEELYGSVEG*" /label="yheA CDS" gene 978971..979324 /gene="yheA" /locus_tag="BSU_09800" /old_locus_tag="BSU09800" /label="yheA gene" downshifts 979312 /Source="Nicolas_upshifts" /id="D522" /incds=0 /nref=159 /ntot=259 /MaxReadThrough="1.55668" /MaxDrop="5.9901" /score="24.5275597" /energy="-12.3" /TU="NA" /idTUdmin="U780" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(979368..980441) /gene="yhaZ" /locus_tag="BSU_09810" /old_locus_tag="BSU09810" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16267290, 22933559" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388862.1" /db_xref="EnsemblGenomes-Gn:BSU09810" /db_xref="EnsemblGenomes-Tr:CAB12820" /db_xref="GOA:O07541" /db_xref="InterPro:IPR011989" /db_xref="InterPro:IPR014825" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR021133" /db_xref="SubtiList:BG13002" /db_xref="UniProtKB/Swiss-Prot:O07541" /translation="MADLKEIYNEELISQLIHHVRSSYPDFNKNRFLDTLRLEDWPEL TLKERMRRVTVSLYETLPKQYVEALTILRDTAPHFKGLSGILFPDYVEQYGLAHWEES IKALESFTQYSTSEFAVRPFLLLDQEKMIAQLLAWSEHKNEHVRRLASEGSRPRLPWG KSIPALKSDPSPVLPILEKLMQDESLYVRKSVANNLNDISKTHPHLLRKVADQWYGTH PHTDWIIKHAYRTLLKKGDKQALALFGYENADSIQLHDLTCQPKRIVIGESLEFSFYI HSDRDQKVRIEYAIDFVKARGQRHQKVFKITETNIRKNETKSYTRIQSFKDLTTRKHY KGIHTLSVIINGEVKDSLDFQVC*" /label="yhaZ CDS" gene complement(979368..980441) /gene="yhaZ" /locus_tag="BSU_09810" /old_locus_tag="BSU09810" /label="yhaZ gene" downshifts complement(979475) /Source="Nicolas_upshifts" /id="D523" /incds=1 /nref=16 /ntot=173 /MaxReadThrough="3.78071" /MaxDrop="3.586" /score="4.43596345" /energy="-12.3" /TU="U781" /idTUdmin="U781" /TUdmin="-109" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(980463..980482) /Source="Nicolas_upshift_promotors" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(980475) /Source="Nicolas_upshifts" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(980496..980503) /Source="Nicolas_upshift_promotors" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 980578..980585 /Source="Nicolas_upshift_promotors" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 980598 /Source="Nicolas_upshifts" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 980600..980619 /Source="Nicolas_upshift_promotors" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 980609..980762 /Source="Nicolas_S_feature" /locus_tag="new_1056384_1056537" /HighExp="M9-stat, BC, T0.30H, T1.30H, Lbstat, T1.0H, T3.30H, T2.0H, T3.0H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S345" downshifts 980719 /Source="Nicolas_upshifts" /id="D524" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="7.40404" /MaxDrop="2.6506" /score="-6.05745557" /energy="-4.8" /TU="U782" /idTUdmin="U782" /TUdmin="-1056" /isTUend="FALSE" /label="downshifts" S_feature 980764..980847 /Source="Nicolas_S_feature" /locus_tag="new_1056539_1056622" /HighExp="M9-stat, B60, T2.0H, T1.30H, T0.30H, T2.30H, T3.0H, T1.0H, Lbtran, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S346" downshifts 980804 /Source="Nicolas_upshifts" /id="D525" /incds=0 /nref=70 /ntot=231 /MaxReadThrough="4.88371" /MaxDrop="4.4099" /score="-6.05745557" /energy="-4.8" /TU="U782" /idTUdmin="U782" /TUdmin="-971" /isTUend="FALSE" /label="downshifts" promotor_-35 980860..980865 /Source="Nicolas_upshift_promotors" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 980881..980899 /Source="Nicolas_upshift_promotors" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 980890 /Source="Nicolas_upshifts" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="upshifts" CDS 980927..981793 /gene="yhaX" /locus_tag="BSU_09830" /old_locus_tag="BSU09830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388864.2" /db_xref="EnsemblGenomes-Gn:BSU09830" /db_xref="EnsemblGenomes-Tr:CAB12822" /db_xref="GOA:O07539" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR036412" /db_xref="PDB:3DNP" /db_xref="SubtiList:BG13000" /db_xref="UniProtKB/Swiss-Prot:O07539" /translation="MSKQLLALNIDGALLRSNGKIHQATKDAIEYVKKKGIYVTLVTN RHFRSAQKIAKSLKLDAKLITHSGAYIAEKIDAPFFEKRISDDHTFNIVQVLESYQCN IRLLHEKYSIGNKKKVNSNLLGKALIHPSDPIFYPVQFVESLSDLLMDEPVSAPVIEV YTEHDIQHDITETITKAFPAVDVIRVNDEKLNIVPKGVSKEAGLALVASELGLSMDDV VAIGHQYDDLPMIELAGLGVAMGNAVPEIKRKADWVTRSNDEQGVAYMMKEYFRMQQR KGFLDKFHMKRV*" /label="yhaX CDS" gene 980927..981793 /gene="yhaX" /locus_tag="BSU_09830" /old_locus_tag="BSU09830" /label="yhaX gene" downshifts 981775 /Source="Nicolas_upshifts" /id="D526" /incds=0 /nref=22 /ntot=67 /MaxReadThrough="3.99904" /MaxDrop="4.7771" /score="15.7706912" /energy="-16.6" /TU="U783" /idTUdmin="U782" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 981838..981841 /Source="Nicolas_upshift_promotors" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 981856..981875 /Source="Nicolas_upshift_promotors" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 981864 /Source="Nicolas_upshifts" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="upshifts" CDS 981905..983410 /gene="hemZ" /locus_tag="BSU_09840" /old_locus_tag="BSU09840" /EC_number="1.3.99.-" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10498703, 21255303" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498703, 21255303; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coproporphyrinogen III oxidase" /protein_id="NP_388865.1" /db_xref="EnsemblGenomes-Gn:BSU09840" /db_xref="EnsemblGenomes-Tr:CAB12823" /db_xref="GOA:Q796V8" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023995" /db_xref="InterPro:IPR034505" /db_xref="SubtiList:BG12999" /db_xref="UniProtKB/Swiss-Prot:Q796V8" /translation="MQIKIEGIHDDRLHRPLQNIANLFYEECELAYGGEEPADFVISL ALSQTDEHVTVSGEVKGTGIKEQHTKFFSPDMTEKEAFKQVKNTISYVYLNLLQAHTG ITQKWGILTGIRPTKLLHKKLQSGMSKEQAHAELKKDYLIHDEKIMLMQEIVDRQLAA VPDLYRVKDEVSIYIGIPFCPTKCAYCTFPAYAIQGQAGRVGSFLWGLHYEMQKIGEW LKEHDVKVTTIYFGGGTPTSITAEEMDLLYEEMVRSFPDVKNIREITVEAGRPDTITE EKLAVLNKYDIDRISINPQSYENETLKAIGRHHTVEETIEKYHLSRQHGMNNINMDLI IGLPGEGVKEFRHSLSETEKLMPESLTVHTLSFKRASEMTRNKHKYKVAGREEVSQMM EDAVAWTKEHGYVPYYLYRQKNILGNLENVGYSLPGQESIYNIMIMEEVQTIIGIGCG AASKFIDRDTGKITHFANPKDPKSYNERFEHYTDEKIKYLEQIFEKTTKQH*" /label="hemZ CDS" gene 981905..983410 /gene="hemZ" /locus_tag="BSU_09840" /old_locus_tag="BSU09840" /label="hemZ gene" downshifts 983380 /Source="Nicolas_upshifts" /id="D527" /incds=0 /nref=113 /ntot=234 /MaxReadThrough="0.523269999999999" /MaxDrop="5.05369" /score="38.1573779" /energy="-14.4" /TU="NA" /idTUdmin="U783" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(983428..984645) /gene="khtU" /locus_tag="BSU_09850" /old_locus_tag="BSU09850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7934942, 14987767, 15849754, 15919996, 16850406, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934942, 14987767, 15849754, 15919996, 16850406, 24330391; Product type t : transporter" /codon_start=1 /transl_table=11 /product="proton/potassium antiporter; methylglyoxal resistance" /protein_id="NP_388866.2" /db_xref="EnsemblGenomes-Gn:BSU09850" /db_xref="EnsemblGenomes-Tr:CAB12825" /db_xref="GOA:O07536" /db_xref="InterPro:IPR006153" /db_xref="SubtiList:BG12997" /db_xref="UniProtKB/Swiss-Prot:O07536" /translation="MDHLVFEVGTALVLVAIASVIANKIKFSIIPFLIVLGMLVGPHA PKMGIIDLTFIQSSEIIEFFGRMGVLFLLFYLGLEFSVGKLIKSGKSIAVGGTIYILI NFSLGLLYGFITGFSFLEVLILAGVITISSSAIVAKVLVDLKRTANPETELILGIIMF EDIFLAVYLSVVSGLILGDATSVGSALLSILIAFGYMLLFFIAARKLPPLLNKLLDIR SNEVFIIVIFAALFFIAGFSETIHVAEAIGALLLGLVFSETEHSDRIEHLVVPFRDFF GAMFFFSFGLSIDPFSLGEAVWLALGAVILTILGNFIAGMVAGRRAGLSHKASSNIGL TIVSRGEFSIIVANLGIAGGLSATLKPFAALYVLILAILGPLVTKESKRIYRLLNKVF KWKPEVQPAKKQG*" /label="khtU CDS" gene complement(983428..984645) /gene="khtU" /locus_tag="BSU_09850" /old_locus_tag="BSU09850" /label="khtU gene" downshifts complement(983434) /Source="Nicolas_upshifts" /id="D528" /incds=0 /nref=154 /ntot=249 /MaxReadThrough="1.74386" /MaxDrop="6.8685" /score="8.64654688" /energy="-14.4" /TU="NA" /idTUdmin="U785" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(984652..985149) /gene="khtT" /locus_tag="BSU_09860" /old_locus_tag="BSU09860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14987767, 17679694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14987767, 17679694; Product type t: transporter" /codon_start=1 /transl_table=11 /product="K+/H+ antiporter for K+ efflux" /protein_id="NP_388867.1" /db_xref="EnsemblGenomes-Gn:BSU09860" /db_xref="EnsemblGenomes-Tr:CAB12826" /db_xref="GOA:O07535" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR026278" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG12996" /db_xref="UniProtKB/Swiss-Prot:O07535" /translation="MNIKENDLPGIGKKFEIETRSHEKMTIIIHDDGRREIYRFNDRD PDELLSNISLDDSEARQIAAILGGMVYKPQALESIEMAFSDLIIEWFKVEKGAKSIGR TLGELDVRQNYDVTVIAIIKHNQEKLLNPGADSIIEENDTLVLSGERKHLKKLIHDFL SGEGV*" /label="khtT CDS" gene complement(984652..985149) /gene="khtT" /locus_tag="BSU_09860" /old_locus_tag="BSU09860" /label="khtT gene" CDS complement(985213..985551) /gene="khtS" /locus_tag="BSU_09870" /old_locus_tag="BSU09870" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14987767, 17679694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14987767, 17679694; Product type t: transporter" /codon_start=1 /transl_table=11 /product="K+/H+ antiporter for K+ efflux" /protein_id="NP_388868.1" /db_xref="EnsemblGenomes-Gn:BSU09870" /db_xref="EnsemblGenomes-Tr:CAB12827" /db_xref="GOA:O07534" /db_xref="SubtiList:BG12995" /db_xref="UniProtKB/Swiss-Prot:O07534" /translation="MRREERNMDKLLISFLLSLFMVYFPPSDVVLPSQFEASTDSYVP MSSYPQETQSAKTPSPGSMHPAELIKEYSPLAQSVRQLSVKPLDEPLINRLEKALAVP VKYQSNYLRI*" /label="khtS CDS" gene complement(985213..985551) /gene="khtS" /locus_tag="BSU_09870" /old_locus_tag="BSU09870" /label="khtS gene" promotor_-10 complement(985563..985582) /Source="Nicolas_upshift_promotors" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(985587) /Source="Nicolas_upshifts" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(985596..985603) /Source="Nicolas_upshift_promotors" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 985623..985630 /Source="Nicolas_upshift_promotors" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 985645..985664 /Source="Nicolas_upshift_promotors" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 985655 /Source="Nicolas_upshifts" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="upshifts" CDS 985716..986483 /gene="yhaR" /locus_tag="BSU_09880" /old_locus_tag="BSU09880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22961985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydratase / isomerase" /protein_id="NP_388869.3" /db_xref="EnsemblGenomes-Gn:BSU09880" /db_xref="EnsemblGenomes-Tr:CAB12828" /db_xref="GOA:O07533" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12994" /db_xref="UniProtKB/Swiss-Prot:O07533" /translation="MEFVQYACNGAVAEIILNRPDAHHALNEQMLSELKEAVEMAAAS EALIVLLRGSGKGFSAGGDIRMMTSEHDPDQFKRLMDTIEAVTLNLYQMKKVTIAAIH GAAAGLGLSLALCADIVLAEKNAVLAMNFIGIGLVPDGGGHYLLKKRIGEAKAKKLIW SGKKLSASEAADMGLLDGTFAGDPAEGARPIIETLLASPLLAMIETKGIFQSLQIEEL KKVLSLERSAQERMRRTKDHQEGIRAFLEKREPKFQA*" /label="yhaR CDS" gene 985716..986483 /gene="yhaR" /locus_tag="BSU_09880" /old_locus_tag="BSU09880" /label="yhaR gene" downshifts 986484 /Source="Nicolas_upshifts" /id="D529" /incds=0 /nref=2 /ntot=99 /MaxReadThrough="1.78111" /MaxDrop="4.66019" /score="-8.79921781" /energy="-7.5" /TU="NA" /idTUdmin="U786" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(986504..986689) /gene="yhzD" /locus_tag="BSU_09889" /old_locus_tag="BSU09889" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097698.1" /db_xref="EnsemblGenomes-Gn:BSU09889" /db_xref="EnsemblGenomes-Tr:CAX52586" /db_xref="InterPro:IPR025544" /db_xref="UniProtKB/Swiss-Prot:C0H3Y1" /translation="MADYFLTVFDPSGNTLVNEQFEAEHEEAAKTHGEALLKEKELHS HTHRLVNAAGKLILFHR*" /label="yhzD CDS" gene complement(986504..986689) /gene="yhzD" /locus_tag="BSU_09889" /old_locus_tag="BSU09889" /label="yhzD gene" promotor_-10 complement(986725..986743) /Source="Nicolas_upshift_promotors" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(986736) /Source="Nicolas_upshifts" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(986754..986762) /Source="Nicolas_upshift_promotors" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 986763..986766 /Source="Nicolas_upshift_promotors" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 986781..986800 /Source="Nicolas_upshift_promotors" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 986791 /Source="Nicolas_upshifts" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="upshifts" CDS 986816..987712 /gene="yhaQ" /locus_tag="BSU_09890" /old_locus_tag="BSU09890" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9106203, 10356997, 12374817; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+-dependent efflux ABC transporter (ATP-binding protein)" /protein_id="NP_388870.2" /db_xref="EnsemblGenomes-Gn:BSU09890" /db_xref="EnsemblGenomes-Tr:CAB12829" /db_xref="GOA:C0SPB4" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR025302" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12993" /db_xref="UniProtKB/Swiss-Prot:C0SPB4" /translation="MLTIDHVTKTFGDYKAVDGLDLDIPEQQMFGLLGANGAGKTTTF RMILGLLSITEGSISWKGRPVNYHISNKIGYLPEERGLYPKMKVRDQLVYLARLKGME KREAVKELGTWLERFNITDYENKKVEELSKGNQQKIQFISAVLHKPELLILDEPFSGL DPVNVELLKEAVISLKNSGVSILFSSHRMEHVEELCENLCILQKGKPVVQGKLKEIKR SFGKKNVTIHSDDDLRFLQSHEGILQWKETADGVKLQIANEDISQEIFAMLQGKGFIR KFELEEPSLHDIFIEKVGAVYE*" /label="yhaQ CDS" gene 986816..987712 /gene="yhaQ" /locus_tag="BSU_09890" /old_locus_tag="BSU09890" /label="yhaQ gene" CDS 987705..988964 /gene="yhaP" /locus_tag="BSU_09900" /old_locus_tag="BSU09900" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9106203, 10356997, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+-dependent exporter (ABC permease)" /protein_id="NP_388871.2" /db_xref="EnsemblGenomes-Gn:BSU09900" /db_xref="EnsemblGenomes-Tr:CAB12830" /db_xref="GOA:O07523" /db_xref="SubtiList:BG12992" /db_xref="UniProtKB/Swiss-Prot:O07523" /translation="MNKFWIMLSHTYKNKIMAKSFIISTVITVLLVLVVTNLESIISL FQGDDAKEKIAVVDETNELYPVFSKQLKAVDTDGDLDVKLSKQSEDEVTKQVKDESLD GMLIIKRDEKGTISGTYKALTISDESTYQTLQQALTQTKTAVGTAELGVSQETISSLY APVTVGQKALKEGAKSEEELGQTVGLVYIMLFVIYFSVIMYASMIAMEVATEKSSRVM EILISSMPPIQQMFAKLLGIGLVGITQLAIIIGAGSLSLKLNQKSETASSVGGFLNLT DVSATTVIYAVIFFLLGYFLYATLAAFLGSVVSRIEDVQQTITPMTLLVVAGFMIAMF GLNAPDAGFITVTSFIPFFTPMIMFLRVGMLDIPFWQAAVGIGITLLTIVILAVIGAR IYKGGVLIYGNSSAFKAIKQALRLAKN*" /label="yhaP CDS" gene 987705..988964 /gene="yhaP" /locus_tag="BSU_09900" /old_locus_tag="BSU09900" /label="yhaP gene" downshifts 988948 /Source="Nicolas_upshifts" /id="D530" /incds=0 /nref=19 /ntot=187 /MaxReadThrough="2.50232" /MaxDrop="3.26822" /score="8.93460501" /energy="-12.8" /TU="NA" /idTUdmin="U788" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 989012..989019 /Source="Nicolas_upshift_promotors" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 989031..989050 /Source="Nicolas_upshift_promotors" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 989036 /Source="Nicolas_upshifts" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="upshifts" CDS 989071..990297 /gene="yhaO" /locus_tag="BSU_09910" /old_locus_tag="BSU09910" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA repair exonuclease" /protein_id="NP_388872.1" /db_xref="EnsemblGenomes-Gn:BSU09910" /db_xref="EnsemblGenomes-Tr:CAB12831" /db_xref="GOA:O07522" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR014576" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12991" /db_xref="UniProtKB/Swiss-Prot:O07522" /translation="MLTDLTFIHAADLHLDSPFYGISHLPEPIFARIKESTFASVRHM IDAAVREHVDFILLAGDLFDEANRSLKAQLFLKKQFERLRECGISVYVIFGNHDHLGG EWTPIEWPENVHIFSSAVPEEKSFFKEGRRIASIYGFSYQARALMENQAARYRRSTDA PFHIGMLHGTLSGSEGHDPYCPFTHDDLVKSGMDYWALGHIHKRQVLSAEHPAVIYPG NTQARHIKETGDKGYYLVHVTNGDISYEFQRAHDVLWEKAAVDVTEAKNMTALFQMVE DTFSKLRKKGSPVCVRLVLQGTAPEWLLEAPKGTLDEFLEALQEQEAEEERFVWPLRL DDETENEANLTNLDPFFGGLFEDIDRSDLSDVLEGLERHPVYRRHADRFSQEEVKEIK EQAQIILKRQLKVLDT*" /label="yhaO CDS" gene 989071..990297 /gene="yhaO" /locus_tag="BSU_09910" /old_locus_tag="BSU09910" /label="yhaO gene" downshifts complement(989772) /Source="Nicolas_upshifts" /id="D531" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="0.0165100000000002" /MaxDrop="3.62411" /score="-5.83060322" /energy="-15.2" /TU="NA" /idTUdmin="U787" /TUdmin="-3300" /isTUend="FALSE" /label="downshifts" CDS 990302..993193 /gene="sbcE" /locus_tag="BSU_09920" /old_locus_tag="BSU09920" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16267290, 19906728, 21517913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16267290, 19906728, 21517913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATPase involved in DNA double strand break repair and recombination" /protein_id="NP_388873.1" /db_xref="EnsemblGenomes-Gn:BSU09920" /db_xref="EnsemblGenomes-Tr:CAB12832" /db_xref="GOA:O08455" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12990" /db_xref="UniProtKB/Swiss-Prot:O08455" /translation="MTALRIISLHIYQYGKFSNRTFDFSASPVQVIYGLNEAGKTTMM SFIESMLFGFPKTKKYEPKTGGVYGGVLEAEHPEYGVLKIERTKGTAEKLSVYTEKGE VKQGDVLKQLFQGTDRSLYKAIYSFDVFGLQEIHAFNRDKIGEFLLFSSLFGAEAVSK LDSRLTKESERLYKPNGRNPQLNQELETLKQLAVKLKQAEAEEAGYHQLLEEKRTLEA RLAAAETELKETAGHIRMIEGAIERKPLLNEKATLEQVIAEFPEHAGQFPADGLHQLE KYESHLHPKSAQLEALRVKMAELDKQRQKLIPDKELLAKETLIQELSAAFHMYQSWGE QLAAIQAQLRQTSAQTAAGLEQLNKTDENELLNMNTSYDYEWQLQQAVQQYVQARDRK RQLDETFELARQELEDAEKAVRAASSAILENSQRKDKEAALRAYDETQGQHQEQAKLR EQLTFFERQQAKQKKTVIAAGMLFIVLFSLLQQWIPAISFGAALIVYWLVSGKSSSRN SRETRQPMTDISPAEAEMLREALWEDDRNKQHLLTQRAALQQKEAAYERVIQQFEQWE AEMAPSFTQVERFMNELGFKEDPSFLLDAYSLMKDVKKEVKKKHELTIEAGRLKKHRR TFEERVSMLLPVNQSQDISISDALHTLRKNIEREKEIEKQKKEIETDIHYTKEQMLEL EQEIQYFHAQIEQLFAAAAAKDRDAFFAIAAISRQLKDTENKLHHVNAQLQGGYPEEL ELADSNTLSELKDKQFVENERKERLTEEIEQLRSQIALLSVKQEQLEASGMVSDLKLQ TEMQKERVKETAKKWASIQMVKQVIRNKLERHKKIELPRLLETAGEFFRPLTDGNYQT IYFSETDDSIMVMHRDGTVYHAEELSQGTCEQLYTAIRFALAVTRQGESKLPFQLDDS FVHFDQERLKRVLHVLYDLSEGGRQILYFTCHEHVKDAFHSSQIIHLVS*" /label="sbcE CDS" gene 990302..993193 /gene="sbcE" /locus_tag="BSU_09920" /old_locus_tag="BSU09920" /label="sbcE gene" promotor_-35 991583..991588 /Source="Nicolas_upshift_promotors" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 991604..991622 /Source="Nicolas_upshift_promotors" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 991610 /Source="Nicolas_upshifts" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 993201..993206 /Source="Nicolas_upshift_promotors" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 993221..993240 /Source="Nicolas_upshift_promotors" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 993236 /Source="Nicolas_upshifts" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="upshifts" CDS 993267..994211 /gene="yhaM" /locus_tag="BSU_09930" /old_locus_tag="BSU09930" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12399495, 15805522, 15983136, 16267290, 19553197, 19880604" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399495, 15805522, 15983136, 16267290, 19553197, 19880604; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="3'-5' exonuclease" /protein_id="NP_388874.1" /db_xref="EnsemblGenomes-Gn:BSU09930" /db_xref="EnsemblGenomes-Tr:CAB12833" /db_xref="GOA:O07521" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR020873" /db_xref="SubtiList:BG12989" /db_xref="UniProtKB/Swiss-Prot:O07521" /translation="MAKGIMLHEVGEQVDQYLLIKSSTKGIASNGKPFLTLMLQDQSG DIEAKLWDAKQSDEVTYAPQTIVKVVGDVHHYRGRTQLKLRNIRPVSEQENVNIDDFL ETAPIPKNEMMDTITQYIFEMKNPNIQRITRFLVKKHEAEFMDYPAATKNHHEFVSGL AYHVVSMLNLAKAIADLYPSLDRDLLYAGVILHDLGKVKELSGPVSTSYTVEGNLLGH ISIMVTELSKAAEELQIDSEEVLILQHLILSHHGKAEWGSPKPPMVKEAEILHYIDNL DAKMNMMDRALERVKPGEYTERVFALENRSFYKPTFHK*" /label="yhaM CDS" gene 993267..994211 /gene="yhaM" /locus_tag="BSU_09930" /old_locus_tag="BSU09930" /label="yhaM gene" downshifts 994189 /Source="Nicolas_upshifts" /id="D532" /incds=0 /nref=183 /ntot=261 /MaxReadThrough="3.02818" /MaxDrop="5.88173" /score="6.06919899" /energy="-15.8" /TU="NA" /idTUdmin="U789" /TUdmin=5 /isTUend="TRUE" /label="downshifts" promotor_-35 994270..994275 /Source="Nicolas_upshift_promotors" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 994291..994309 /Source="Nicolas_upshift_promotors" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 994294 /Source="Nicolas_upshifts" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="upshifts" CDS 994336..994548 /gene="yhaL" /locus_tag="BSU_09940" /old_locus_tag="BSU09940" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523133; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="sporulation factor" /protein_id="NP_388875.1" /db_xref="EnsemblGenomes-Gn:BSU09940" /db_xref="EnsemblGenomes-Tr:CAB12834" /db_xref="GOA:O07520" /db_xref="InterPro:IPR025428" /db_xref="SubtiList:BG12988" /db_xref="UniProtKB/Swiss-Prot:O07520" /translation="MLFFPWWVYLCIVGIIFSAYKLVAAAKEEEKVDQAFIEKEGQIY MERMEKERERRSSQQHEEENQNHSIA*" /label="yhaL CDS" gene 994336..994548 /gene="yhaL" /locus_tag="BSU_09940" /old_locus_tag="BSU09940" /label="yhaL gene" downshifts 994541 /Source="Nicolas_upshifts" /id="D533" /incds=0 /nref=8 /ntot=158 /MaxReadThrough="2.03283" /MaxDrop="6.60832" /score="62.1892984" /energy="-22" /TU="NA" /idTUdmin="U792" /TUdmin=5 /isTUend="TRUE" /label="downshifts" downshifts complement(994579) /Source="Nicolas_upshifts" /id="D534" /incds=0 /nref=97 /ntot=260 /MaxReadThrough="0.90997" /MaxDrop="9.00938" /score="52.3375501" /energy="-22" /TU="NA" /idTUdmin="U793" /TUdmin=11 /isTUend="TRUE" /label="downshifts" CDS complement(994589..995467) /gene="prsA" /locus_tag="BSU_09950" /old_locus_tag="BSU09950" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12634326, 12682299, 14976191, 16516208, 25525259, 26711778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12634326, 12682299, 14976191, 16516208, 25525259, 26711778; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="molecular chaperone lipoprotein" /protein_id="NP_388876.1" /db_xref="EnsemblGenomes-Gn:BSU09950" /db_xref="EnsemblGenomes-Tr:CAB12835" /db_xref="GOA:P24327" /db_xref="InterPro:IPR000297" /db_xref="InterPro:IPR008880" /db_xref="InterPro:IPR023058" /db_xref="InterPro:IPR023059" /db_xref="InterPro:IPR027304" /db_xref="PDB:1ZK6" /db_xref="PDB:4WO7" /db_xref="SubtiList:BG10464" /db_xref="UniProtKB/Swiss-Prot:P24327" /translation="MKKIAIAAITATSILALSACSSGDKEVIAKTDAGDVTKGELYTN MKKTAGASVLTQLVQEKVLDKKYKVSDKEIDNKLKEYKTQLGDQYTALEKQYGKDYLK EQVKYELLTQKAAKDNIKVTDADIKEYWEGLKGKIRASHILVADKKTAEEVEKKLKKG EKFEDLAKEYSTDSSASKGGDLGWFAKEGQMDETFSKAAFKLKTGEVSDPVKTQYGYH IIKKTEERGKYDDMKKELKSEVLEQKLNDNAAVQEAVQKVMKKADIEVKDKDLKDTFN TSSTSNSTSSSSSNSK*" /label="prsA CDS" gene complement(994589..995467) /gene="prsA" /locus_tag="BSU_09950" /old_locus_tag="BSU09950" /label="prsA gene" downshifts complement(994777) /Source="Nicolas_upshifts" /id="D535" /incds=1 /nref=10 /ntot=127 /MaxReadThrough="7.54458" /MaxDrop="3.5906" /score="52.3375501" /energy="-22" /TU="U793" /idTUdmin="U793" /TUdmin="-187" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(995505..995524) /Source="Nicolas_upshift_promotors" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(995529) /Source="Nicolas_upshifts" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(995538..995545) /Source="Nicolas_upshift_promotors" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 995565..995574 /Source="Nicolas_upshift_promotors" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 995586 /Source="Nicolas_upshifts" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 995587..995606 /Source="Nicolas_upshift_promotors" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(995623..995637) /Source="Nicolas_upshift_promotors" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(995624) /Source="Nicolas_upshifts" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 995627..995713 /gene="sscA" /locus_tag="BSU_09958" /old_locus_tag="BSU09958" /function="15.7: Sporulation and germination" /experiment="publication(s) with functional evidences, PMID:20156992, 21670523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20156992, 21670523; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="spore assembly and germination protein" /protein_id="YP_003097699.1" /db_xref="EnsemblGenomes-Gn:BSU09958" /db_xref="EnsemblGenomes-Tr:CAX52587" /db_xref="GOA:C0H3Y2" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3Y2" /translation="MSGGYSNGFALLVVLFILLIIVGAAYIY*" /label="sscA CDS" gene 995627..995713 /gene="sscA" /locus_tag="BSU_09958" /old_locus_tag="BSU09958" /label="sscA gene" promotor_-35 complement(995646..995650) /Source="Nicolas_upshift_promotors" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 995714..995965 /Source="Nicolas_S_feature" /locus_tag="new_1071489_1071740" /HighExp="S8, S7, S6, BT, G/S, B36, Pyr, S5, B60, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba=1 /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S347" CDS 995838..995924 /gene="sscB" /locus_tag="BSU_09959" /old_locus_tag="BSU09959" /function="15.7: Sporulation and germination" /experiment="publication(s) with functional evidences, PMID:21670523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore and germination protein" /protein_id="YP_009513948.1" /db_xref="EnsemblGenomes-Gn:BSU09959" /db_xref="EnsemblGenomes-Tr:CCQ48595" /db_xref="GOA:L8EBJ6" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/TrEMBL:L8EBJ6" /translation="MGEVFAGGFALLVVLFILLIIIGASWLY*" /label="sscB CDS" gene 995838..995924 /gene="sscB" /locus_tag="BSU_09959" /old_locus_tag="BSU09959" /label="sscB gene" downshifts 995922 /Source="Nicolas_upshifts" /id="D536" /incds=0 /nref=28 /ntot=50 /MaxReadThrough="4.67734" /MaxDrop="4.7906" /score="14.3797211" /energy="-17.6" /TU="U794" /idTUdmin="U794" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" S_feature complement(995934..996196) /Source="Nicolas_S_feature" /locus_tag="new_1071709_1071971_c" /HighExp="LBGtran, LBGstat, LPhT, LBGexp, HPh, dia15, T0.30H, dia0, G180, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.995" /TUlongSig="SigA" /TUlongPSig="0.989" /label="S348" S_feature 995967..996450 /Source="Nicolas_S_feature" /locus_tag="new_1071742_1072225" /HighExp="S8, S6, S7, BT, C30, S5, Pyr, Glucon, G/S, C90" /AntisenseName="yhaJ" /AntisenseCor="-0.22462434208606599" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S349" downshifts complement(995977) /Source="Nicolas_upshifts" /id="D537" /incds=0 /nref=153 /ntot=265 /MaxReadThrough="1.32339" /MaxDrop="6.55635" /score="34.7913848" /energy="-17.6" /TU="NA" /idTUdmin="U796" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(996189..996208) /Source="Nicolas_upshift_promotors" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(996196) /Source="Nicolas_upshifts" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(996198..996266) /Source="Nicolas_S_feature" /locus_tag="new_1071973_1072041_c" /HighExp="Paraq, G180, C30, LBGexp, Oxctl, G135, Lbexp, Heat, G150, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29568499999999998" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.989" /label="S350" promotor_-35 complement(996222..996227) /Source="Nicolas_upshift_promotors" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(996267..996785) /gene="yhaJ" /locus_tag="BSU_09965" /old_locus_tag="BSU09965" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009, 21670523, 25651892; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane enzyme" /protein_id="NP_388878.2" /db_xref="EnsemblGenomes-Gn:BSU09965" /db_xref="EnsemblGenomes-Tr:CAB12837" /db_xref="GOA:O07518" /db_xref="InterPro:IPR021683" /db_xref="SubtiList:BG12986" /db_xref="UniProtKB/Swiss-Prot:O07518" /translation="MNCWKTINLMKDYGAVRIILTAVCFMILVFISTFLAFELLRPGT SLSDEYVSLFGGLLVVILFVHKVIHVLPIICKKRKIEKKFYILRMRTWKRIPKTTMLI SLVSPFLLITPVLFYAALAFPNHAHYFCMISGIHAGYCLPDFLLALKLIKAPKTAFID QEADGLDILVEK*" /label="yhaJ CDS" gene complement(996267..996785) /gene="yhaJ" /locus_tag="BSU_09965" /old_locus_tag="BSU09965" /label="yhaJ gene" promotor_-35 996572..996580 /Source="Nicolas_upshift_promotors" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 996592..996610 /Source="Nicolas_upshift_promotors" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 996605 /Source="Nicolas_upshifts" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(996816..996835) /Source="Nicolas_upshift_promotors" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(996834) /Source="Nicolas_upshifts" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(996851..996857) /Source="Nicolas_upshift_promotors" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 996934..996937 /Source="Nicolas_upshift_promotors" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 996952..996971 /Source="Nicolas_upshift_promotors" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 996957 /Source="Nicolas_upshifts" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="upshifts" CDS 996993..997334 /gene="yhaI" /locus_tag="BSU_09980" /old_locus_tag="BSU09980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388879.1" /db_xref="EnsemblGenomes-Gn:BSU09980" /db_xref="EnsemblGenomes-Tr:CAB12838" /db_xref="InterPro:IPR015058" /db_xref="InterPro:IPR035945" /db_xref="PDB:1SED" /db_xref="SubtiList:BG12985" /db_xref="UniProtKB/Swiss-Prot:O07517" /translation="MDSMDHRIERLEYYIQLLVKTVDMDRYPFYALLIDKGLSKEEGE AVMRICDELSEELATQKAQGFVTFDKLLALFAGQLNEKLDVHETIFALYEQGLYQELM EVFIDIMKHFD*" /label="yhaI CDS" gene 996993..997334 /gene="yhaI" /locus_tag="BSU_09980" /old_locus_tag="BSU09980" /label="yhaI gene" S_feature complement(997188..997330) /Source="Nicolas_S_feature" /locus_tag="new_1072963_1073105_c" /HighExp="BC, S1, Sw, S2, S3, S8, S5, S4, S6, S7" /AntisenseName="yhaI" /AntisenseCor="5.4889858269512502E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S351" downshifts complement(997231) /Source="Nicolas_upshifts" /id="D538" /incds=1 /nref=39 /ntot=209 /MaxReadThrough="2.89899" /MaxDrop="4.77791" /score="-6.0983333" /energy="-12.3" /TU="U801" /idTUdmin="U801" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS complement(997331..997942) /gene="scoC" /locus_tag="BSU_09990" /old_locus_tag="BSU09990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14629015, 15126467, 16321961, 16923912, 19801406, 20382764, 23660663, 25966844, 26473603, 26728191, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14629015, 15126467, 16321961, 16923912, 19801406, 20382764, 23660663, 25966844, 26473603, 26728191, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of extracellular protease production, sporulation and bacilysin production (MarR family)" /protein_id="NP_388880.1" /db_xref="EnsemblGenomes-Gn:BSU09990" /db_xref="EnsemblGenomes-Tr:CAB12839" /db_xref="GOA:P11065" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR023488" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2FXA" /db_xref="SubtiList:BG10659" /db_xref="UniProtKB/Swiss-Prot:P11065" /translation="MNRVEPPYDVKEALVFTQKMAQLSKALWKSIEKDWQQWLKPYDL NINEHHILWIAYQLNGASISEIAKFGVMHVSTAFNFSKKLEERGYLRFSKRLNDKRNT YVQLTEEGTEVFWSLLEEFDPTRNAVFKGSQPLYHLFGKFPEVAEMMCMIRHIYGDDF MEIFETSLTNIDNDFESVNGKLKKKAKDSAADEPAEELEPVNS*" /label="scoC CDS" gene complement(997331..997942) /gene="scoC" /locus_tag="BSU_09990" /old_locus_tag="BSU09990" /label="scoC gene" S_feature 997335..998100 /Source="Nicolas_S_feature" /locus_tag="new_1073110_1073875" /HighExp="Lbstat, Etha, T0.30H, Gly, M0t90, M40t90, M40t45, M0t45, H2O2, dia15" /AntisenseName="scoC" /AntisenseCor="-0.46322626361720198" /AntisenseRegPval="-15" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S352" downshifts complement(997407) /Source="Nicolas_upshifts" /id="D539" /incds=1 /nref=1 /ntot=81 /MaxReadThrough="5.81117" /MaxDrop="2.1632" /score="-6.0983333" /energy="-12.3" /TU="U801" /idTUdmin="U801" /TUdmin="-550" /isTUend="FALSE" /label="downshifts" promotor_-35 997938..997942 /Source="Nicolas_upshift_promotors" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 997950..997963 /Source="Nicolas_upshift_promotors" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 997962 /Source="Nicolas_upshifts" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(997967..997986) /Source="Nicolas_upshift_promotors" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="promotor_-10" upshifts complement(997990) /Source="Nicolas_upshifts" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="upshifts" promotor_-35 complement(998001..998004) /Source="Nicolas_upshift_promotors" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="promotor_-35" downshifts 998057 /Source="Nicolas_upshifts" /id="D540" /incds=0 /nref=1 /ntot=124 /MaxReadThrough="3.007" /MaxDrop="2.86547" /score="17.8486533" /energy="-7.1" /TU="U799,U800" /idTUdmin="U799" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(998120..998476) /gene="yhaH" /locus_tag="BSU_10000" /old_locus_tag="BSU10000" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11429463; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein; acid tolerance protein" /protein_id="NP_388881.1" /db_xref="EnsemblGenomes-Gn:BSU10000" /db_xref="EnsemblGenomes-Tr:CAB12840" /db_xref="GOA:O07516" /db_xref="InterPro:IPR024623" /db_xref="InterPro:IPR036191" /db_xref="SubtiList:BG12984" /db_xref="UniProtKB/Swiss-Prot:O07516" /translation="MASGRSLLTGLFVGGIIGGAAVLLTAPSSGKQLREKMKTNYDSF EETIKRLKSDGLALKDQLIKAAKESTDVIKDVGGELQTSIKKWQEEIKPHQQDLQKEI ADIEEKIRQLEKTLQN*" /label="yhaH CDS" gene complement(998120..998476) /gene="yhaH" /locus_tag="BSU_10000" /old_locus_tag="BSU10000" /label="yhaH gene" downshifts complement(998124) /Source="Nicolas_upshifts" /id="D541" /incds=0 /nref=254 /ntot=287 /MaxReadThrough="1.65317" /MaxDrop="7.37381" /score="10.8990112" /energy="-7.9" /TU="NA" /idTUdmin="U804" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 998553..998558 /Source="Nicolas_upshift_promotors" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(998559..998578) /Source="Nicolas_upshift_promotors" /id="U802" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1914 /SigmaFactorBS="aggataatacaatcaaaaagacagacaaccttctccctcctt ttcacttaaaaaaTATGCTAAAATAAAGCAAGCtatgtatagaagttcaggctttcaa c" /listShort="yhaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(998573) /Source="Nicolas_upshifts" /id="U802" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1914 /SigmaFactorBS="aggataatacaatcaaaaagacagacaaccttctccctcctt ttcacttaaaaaaTATGCTAAAATAAAGCAAGCtatgtatagaagttcaggctttcaa c" /listShort="yhaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 998574..998592 /Source="Nicolas_upshift_promotors" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 998574 /Source="Nicolas_upshifts" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(998575..998838) /Source="Nicolas_S_feature" /locus_tag="new_1074350_1074613_c" /HighExp="Etha, Salt, HiTm, Heat, Diami, Sw, Gly, S1, MG 10, MG 60" /AntisenseName="yhzF" /AntisenseCor="-0.69425315975357205" /AntisenseRegPval="-39.299999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.969, 0.962, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S353" CDS 998606..998797 /gene="yhzF" /locus_tag="BSU_10009" /old_locus_tag="BSU10009" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="membrane protein of unknown function" /protein_id="YP_003097700.1" /db_xref="EnsemblGenomes-Gn:BSU10009" /db_xref="EnsemblGenomes-Tr:CAX52588" /db_xref="GOA:C0H3Y3" /db_xref="UniProtKB/Swiss-Prot:C0H3Y3" /translation="MSVFLIVLSCITLAFASGAVYYIKLLSQAASYPPKRVIRQKALV CSTGTAFTLCLIFFTKLLA*" /label="yhzF CDS" gene 998606..998797 /gene="yhzF" /locus_tag="BSU_10009" /old_locus_tag="BSU10009" /label="yhzF gene" S_feature 998798..1000233 /Source="Nicolas_S_feature" /locus_tag="new_1074573_1076008" /HighExp="S3, S8, S4, S6, S7, T5.0H, C30, S5, T4.0H, T3.30H" /AntisenseName="trpP" /AntisenseCor="-0.20038256384636899" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S354" CDS complement(998871..999389) /gene="trpP" /locus_tag="BSU_10010" /old_locus_tag="BSU10010" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735881, 14702295, 15849754, 16850406, 16879415, 17114263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735881, 14702295, 15849754, 16850406, 16879415, 17114263; Product type t : transporter" /codon_start=1 /transl_table=11 /product="tryptophan transporter or sensor" /protein_id="NP_388882.2" /db_xref="EnsemblGenomes-Gn:BSU10010" /db_xref="EnsemblGenomes-Tr:CAB12841" /db_xref="GOA:O07515" /db_xref="InterPro:IPR031360" /db_xref="SubtiList:BG12983" /db_xref="UniProtKB/Swiss-Prot:O07515" /translation="MKTKELVIMALFAAIGAALHSIIPPFLGGMKPDMMLIMMFMGIL LFPRVQNVLVIGIVTGIISALTTAFPAGQIPNIIDKPVSAFLFFSLFLLFRKSRKTGA AAVLTVIGTILSGIVFLSSALLIVGLPGGFAALFAAVVLPAAVLNTISMIIIYPIVQT ILRRSSFMEAAK*" /label="trpP CDS" gene complement(998871..999389) /gene="trpP" /locus_tag="BSU_10010" /old_locus_tag="BSU10010" /label="trpP gene" downshifts complement(998883) /Source="Nicolas_upshifts" /id="D542" /incds=0 /nref=105 /ntot=253 /MaxReadThrough="6.00956" /MaxDrop="4.62812" /score="24.5949542" /energy="-12.8" /TU="U804,U805,U806" /idTUdmin="U804" /TUdmin="-750" /isTUend="FALSE" /label="downshifts" S_feature complement(999390..999477) /Source="Nicolas_S_feature" /locus_tag="new_1075165_1075252_c" /HighExp="C90, B60, S1, GM 15, MG 45, MG-0.2, Etha, Lbtran, MG 25, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.969, 0.962, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S355" promotor_-10 complement(999469..999488) /Source="Nicolas_upshift_promotors" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(999477) /Source="Nicolas_upshifts" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(999502..999509) /Source="Nicolas_upshift_promotors" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(999514..1000593) /gene="serC" /locus_tag="BSU_10020" /old_locus_tag="BSU10020" /EC_number="2.6.1.52" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4337849, 16233211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4337849, 16233211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoserine aminotransferase" /protein_id="NP_388883.1" /db_xref="EnsemblGenomes-Gn:BSU10020" /db_xref="EnsemblGenomes-Tr:CAB12842" /db_xref="GOA:P80862" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="InterPro:IPR022278" /db_xref="SubtiList:BG12673" /db_xref="UniProtKB/Swiss-Prot:P80862" /translation="MERTTNFNAGPAALPLEVLQKAQKEFIDFNESGMSVMELSHRSK EYEAVHQKAKSLLIELMGIPEDYDILFLQGGASLQFSMLPMNFLTPEKTAHFVMTGAW SEKALAETKLFGNTSITATSETDNYSYIPEVDLTDVKDGAYLHITSNNTIFGTQWQEF PNSPIPLVADMSSDILSRKIDVSKFDVIYGGAQKNLGPSGVTVVIMKKSWLQNENANV PKILKYSTHVKADSLYNTPPTFAIYMLSLVLEWLKENGGVEAVEQRNEQKAQVLYSCI DESNGFYKGHARKDSRSRMNVTFTLRDDELTKTFVQKAKDAKMIGLGGHRSVGGCRAS IYNAVSLEDCEKLAAFMKKFQQENE*" /label="serC CDS" gene complement(999514..1000593) /gene="serC" /locus_tag="BSU_10020" /old_locus_tag="BSU10020" /label="serC gene" misc_feature complement(1000632..1000651) /Source="Nicolas_upshift_promotors" /id="U805" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.962037962037962" /xcortree=3059 /SigmaFactorBS="atccgtcaatttcttttgataattctaattttttatcaaaaa actgaattttTGTGATAGGATAATTGTATTattttatacattaacgtggaaaacaggg a" /listShort="serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1000643) /Source="Nicolas_upshifts" /id="U805" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.962037962037962" /xcortree=3059 /SigmaFactorBS="atccgtcaatttcttttgataattctaattttttatcaaaaa actgaattttTGTGATAGGATAATTGTATTattttatacattaacgtggaaaacaggg a" /listShort="serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1000645..1000726) /Source="Nicolas_S_feature" /locus_tag="new_1076420_1076501_c" /HighExp="Etha, dia15, H2O2, LBGtran, G135, G180, dia5, G150, Lbexp, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S356" CDS complement(1000740..1001177) /gene="hinT" /locus_tag="BSU_10030" /old_locus_tag="BSU10030" /EC_number="3.6.1.29" /EC_number="3.6.1.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579061, 15703176, 16934294, 17217311, 26181368, 28516732; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="promiscuous Hit-family phosphohydrolase, adenosine phosphoramidase" /protein_id="NP_388884.1" /db_xref="EnsemblGenomes-Gn:BSU10030" /db_xref="EnsemblGenomes-Tr:CAB12843" /db_xref="GOA:O07513" /db_xref="InterPro:IPR001310" /db_xref="InterPro:IPR011146" /db_xref="InterPro:IPR019808" /db_xref="InterPro:IPR036265" /db_xref="PDB:1Y23" /db_xref="SubtiList:BG12607" /db_xref="UniProtKB/Swiss-Prot:O07513" /translation="MHCAENCIFCKIIAGDIPSAKVYEDEHVLAFLDISQVTKGHTLV IPKTHIENVYEFTDELAKQYFHAVPKIARAIRDEFEPIGLNTLNNNGEKAGQSVFHYH MHIIPRYGKGDGFGAVWKTHADDYKPEDLQNISSSIAKRLASS*" /label="hinT CDS" gene complement(1000740..1001177) /gene="hinT" /locus_tag="BSU_10030" /old_locus_tag="BSU10030" /label="hinT gene" downshifts complement(1000771) /Source="Nicolas_upshifts" /id="D543" /incds=0 /nref=187 /ntot=248 /MaxReadThrough="4.31506" /MaxDrop="5.61862" /score="-0.366845751" /energy="-8.6" /TU="U806" /idTUdmin="U807" /TUdmin=4 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1001210..1001229) /Source="Nicolas_upshift_promotors" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1001224) /Source="Nicolas_upshifts" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="upshifts" downshifts 1001227 /Source="Nicolas_upshifts" /id="D544" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.3752" /MaxDrop="3.02008" /score="-3.56654132" /energy="-13.3" /TU="NA" /idTUdmin="U803" /TUdmin=1034 /isTUend="FALSE" /label="downshifts" promotor_-35 complement(1001243..1001250) /Source="Nicolas_upshift_promotors" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1001249..1001545) /Source="Nicolas_S_feature" /locus_tag="new_1077024_1077320_c" /HighExp="S7, S8, S6, S5, BT, ferm, nit, G/S, S4, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S357" downshifts complement(1001292) /Source="Nicolas_upshifts" /id="D545" /incds=0 /nref=40 /ntot=72 /MaxReadThrough="3.07347" /MaxDrop="7.69075" /score="9.88617558" /energy="-14.2" /TU="U807" /idTUdmin="U807" /TUdmin="-517" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1001543..1001554) /Source="Nicolas_upshift_promotors" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1001549) /Source="Nicolas_upshifts" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1001569..1001575) /Source="Nicolas_upshift_promotors" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1001605..1001612 /Source="Nicolas_upshift_promotors" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1001626..1001645 /Source="Nicolas_upshift_promotors" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1001635 /Source="Nicolas_upshifts" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="upshifts" CDS 1001665..1002408 /gene="ecsA" /locus_tag="BSU_10040" /old_locus_tag="BSU10040" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8581172, 10027970, 11807061, 18599827, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8581172, 10027970, 11807061, 18599827, 26735940; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein)" /protein_id="NP_388885.1" /db_xref="EnsemblGenomes-Gn:BSU10040" /db_xref="EnsemblGenomes-Tr:CAB12844" /db_xref="GOA:P55339" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11516" /db_xref="UniProtKB/Swiss-Prot:P55339" /translation="MSLLSVKDLTGGYTRNPVLKNVSFTLEPNQIVGLIGLNGAGKST TIRHIIGLMDPHKGSIELNGKTFAEDPEGYRSQFTYIPETPVLYEELTLMEHLELTAM AYGLSKETMEKRLPPLLKEFRMEKRLKWFPAHFSKGMKQKVMIMCAFLAEPALYIIDE PFLGLDPLAINALLERMNEAKKGGASVLMSTHILATAERYCDSFIILHNGEVRARGTL SELREQFGMKDAALDDLYLELTKEDAGHE*" /label="ecsA CDS" gene 1001665..1002408 /gene="ecsA" /locus_tag="BSU_10040" /old_locus_tag="BSU10040" /label="ecsA gene" CDS 1002401..1003627 /gene="ecsB" /locus_tag="BSU_10050" /old_locus_tag="BSU10050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8581172, 10027970, 15175311, 15849754, 16850406, 18599827, 21665535, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8581172, 10027970, 15175311, 15849754, 16850406, 18599827, 21665535, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease subunit)" /protein_id="NP_388886.1" /db_xref="EnsemblGenomes-Gn:BSU10050" /db_xref="EnsemblGenomes-Tr:CAB12845" /db_xref="GOA:P55340" /db_xref="InterPro:IPR010288" /db_xref="SubtiList:BG11517" /db_xref="UniProtKB/Swiss-Prot:P55340" /translation="MNNMLDIWQSRLQEHIKETRTYMKYMLNDHLVIVLIFFLAGAAS WYSKWIRDIPAHFPSFWVMAVLFSLVLTSSYVRTLLKEADLVFLLPLEAKMEPYLKQA FVYSYVSQLFPLIALSIVAMPLYFAVTPGASLVSYAAVFVQLLLLKAWNQVMEWRTTF QNDRSMKRMDVIIRFAANTLVLYFVFQSVYMYALLVYVIMAVLYLYMSSAAKRKTFKW ESHIESELRRKQRFYRIANLFTDVPHLRKQAKRRAYLDFLLRLVPFEQRKTFAYMFTR AFLRSSDYLGILVRLTIVFALIIMYVSASPLIAAVLTVFAIFITGIQLLPLFGHFDHL ALQELYPVQKETKLKSYFSLLKTALSIQALLMSVASAYAAGLTGFLYALIGSAVLIFV VLPAYMTTRLKKHGKL*" /label="ecsB CDS" gene 1002401..1003627 /gene="ecsB" /locus_tag="BSU_10050" /old_locus_tag="BSU10050" /label="ecsB gene" promotor_-10 complement(1002960..1002978) /Source="Nicolas_upshift_promotors" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1002975) /Source="Nicolas_upshifts" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1002994..1002999) /Source="Nicolas_upshift_promotors" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1003647..1004357 /gene="ecsC" /locus_tag="BSU_10060" /old_locus_tag="BSU10060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8581172, 10027970; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388887.1" /db_xref="EnsemblGenomes-Gn:BSU10060" /db_xref="EnsemblGenomes-Tr:CAB12846" /db_xref="InterPro:IPR024787" /db_xref="SubtiList:BG11518" /db_xref="UniProtKB/Swiss-Prot:P55341" /translation="MTDNQLLMQEALEWKMHFLRKDSMFERFSKRVQTKVNERIPEKI HTVVTESVKKMVEATMAGSNIITYKKDTSALSLSEKNELAKKTIVSYQKVAAAEGVGT GAGGIFLSIADFPLLLSIKMKCLFTLSSIYGFDVKDAQERIFLLLVFQLAFSSDDGRK SLFSVIENWETEKKSIDWRVFQQEYRDYIDVVKLFQLLPGVGAAVGGIANYKLLAQLG ETARHVFHLRILKETAGE*" /label="ecsC CDS" gene 1003647..1004357 /gene="ecsC" /locus_tag="BSU_10060" /old_locus_tag="BSU10060" /label="ecsC gene" downshifts 1004321 /Source="Nicolas_upshifts" /id="D546" /incds=0 /nref=78 /ntot=231 /MaxReadThrough="1.36097" /MaxDrop="4.78417" /score="28.5337351" /energy="-14.6" /TU="NA" /idTUdmin="U808" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(1004375..1005565) /gene="sndC" /locus_tag="BSU_10070" /old_locus_tag="BSU10070" /EC_number="3.5.1.-" /experiment="publication(s) with functional evidences, PMID:23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl amino acid acetylase, promiscuous activity" /protein_id="NP_388888.2" /db_xref="EnsemblGenomes-Gn:BSU10070" /db_xref="EnsemblGenomes-Tr:CAB12847" /db_xref="GOA:O07598" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12982" /db_xref="UniProtKB/Swiss-Prot:O07598" /translation="MSISTLQKEINKQLDGCFEEMVEIRRHFHMYPELSFQEEKTAAF IASYYESLGVPIRTNVGGRGVLANIEGSEPGPTVALRADFDALPIQDEKDVPYASKVP GVMHACGHDGHTAALLAVAKVLHQNRHELKGTFVMIHQHAEEYYPGGAKPMIDDGCLE NTDVIFGTHLWATEPLGTILCRPGAVMAAADRFTIKVFGKGGHGAHPHDTKDAVLIGS QIVSSLQHIVSRKVNPIQSAVISTGSFIADNPFNVIADQAVLIGTARSFDENVRDILE KEIEAVVKGICSMHGASYEYTYEQGYPAVVNHPAETNHLVSTAKNTEGVQQVIDGEPQ MGGEDFAYYLQNVKGTFFFTGAAPEQPERVYSHHHPKFDINEKAMLTAAKVLAGAAIT YHQL*" /label="sndC CDS" gene complement(1004375..1005565) /gene="sndC" /locus_tag="BSU_10070" /old_locus_tag="BSU10070" /label="sndC gene" downshifts complement(1004385) /Source="Nicolas_upshifts" /id="D547" /incds=0 /nref=11 /ntot=162 /MaxReadThrough="3.12546" /MaxDrop="4.15559" /score="-4.78420642" /energy="-14.6" /TU="U810" /idTUdmin="U811" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" downshifts complement(1004450) /Source="Nicolas_upshifts" /id="D548" /incds=1 /nref=25 /ntot=206 /MaxReadThrough="4.92378" /MaxDrop="3.21645" /score="-4.78420642" /energy="-14.6" /TU="U810,U811" /idTUdmin="U811" /TUdmin="-67" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1005589..1005608) /Source="Nicolas_upshift_promotors" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1005610) /Source="Nicolas_upshifts" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1005622..1005627) /Source="Nicolas_upshift_promotors" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1005638..1007029) /gene="yhfA" /locus_tag="BSU_10080" /old_locus_tag="BSU10080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 12107147; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_388889.1" /db_xref="EnsemblGenomes-Gn:BSU10080" /db_xref="EnsemblGenomes-Tr:CAB12848" /db_xref="GOA:O07599" /db_xref="SubtiList:BG13047" /db_xref="UniProtKB/Swiss-Prot:O07599" /translation="MMEVGILPVHVLYVFFIGAIILFMLLRKDTTFISLFGIFIISLW ASHSLSASVSSLFHSFIYAAGELLPTIFIICFIVSMSDLLTKTGINEAMISPFASLVR GPVTAYWLIGGLMFAISLFFWPSPGVALIGAVLLPAAARAGLTPLAAAMAMNLFGHGF ALSGDFVIQAAPKLTADAAGIPVGDVVSASIPLVLIMGVTTTTAAFIMIQRERKKQEH PTSFSPVLSGEQDNSLYLPKRLRSILAFLIPLAFLADIACMLLFNLQGNDATALIGGS AICILFTVHFFVYKHKGLEKITGYFIDGFKFGFKVFGPVIPIAAFFYLGDSGYESILG TSLPKGSHGIVNDLGIALSHMMPMSKELAATALTAAGAITGLDGSGFSGISLAGSIAK LFSSALHADPAILTALGQISAIWVGGGTLVPWALIPAAAICKVDPFELARKNFIPVAI GLLVTTLAAVMML*" /label="yhfA CDS" gene complement(1005638..1007029) /gene="yhfA" /locus_tag="BSU_10080" /old_locus_tag="BSU10080" /label="yhfA gene" promotor_-10 complement(1007040..1007059) /Source="Nicolas_upshift_promotors" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1007045) /Source="Nicolas_upshifts" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1007072..1007081) /Source="Nicolas_upshift_promotors" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1007095..1007409) /gene="yhgB" /locus_tag="BSU_10090" /old_locus_tag="BSU10090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388890.1" /db_xref="EnsemblGenomes-Gn:BSU10090" /db_xref="EnsemblGenomes-Tr:CAB12849" /db_xref="SubtiList:BG10426" /db_xref="UniProtKB/Swiss-Prot:P38048" /translation="MKHTCPVCGFKDWLNRHMIMKAIILMKSARAAVFSSDLMSTRCS TRITHIEPSESIIAYRKNWLAEGCVIFSPECFPKHLQKANRGLRHHLIEQLKQINVHL PS*" /label="yhgB CDS" gene complement(1007095..1007409) /gene="yhgB" /locus_tag="BSU_10090" /old_locus_tag="BSU10090" /label="yhgB gene" CDS complement(1007454..1007954) /gene="hmoB" /locus_tag="BSU_10100" /old_locus_tag="BSU10100" /EC_number="1.14.99.48" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:21873409, 22531134, 24582752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21873409, 22531134, 24582752; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heme-degrading monooxygenase" /protein_id="NP_388891.1" /db_xref="EnsemblGenomes-Gn:BSU10100" /db_xref="EnsemblGenomes-Tr:CAB12850" /db_xref="GOA:P38049" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:4OZ5" /db_xref="SubtiList:BG10427" /db_xref="UniProtKB/Swiss-Prot:P38049" /translation="MKVYITYGTADFLKTIVQKHPSENILLMQGQENAILIHETNGDT VFQAPHAYEVIDQVGEIKHPGFAVLNNIAVTQEGRPLFENRFKNRAGKVENEPGFEAI RVLRPLDSDTYVILTLWETESAFQDWQQSGSYKEAHKKRDTSAGIDTTSIFSRPSYVT TYFAVE*" /label="hmoB CDS" gene complement(1007454..1007954) /gene="hmoB" /locus_tag="BSU_10100" /old_locus_tag="BSU10100" /label="hmoB gene" downshifts complement(1007481) /Source="Nicolas_upshifts" /id="D549" /incds=0 /nref=145 /ntot=254 /MaxReadThrough="3.45185" /MaxDrop="5.6374" /score="15.5142908" /energy="-14.8" /TU="U812" /idTUdmin="U812" /TUdmin="-546" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1007967..1007986) /Source="Nicolas_upshift_promotors" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1007969..1007973 /Source="Nicolas_upshift_promotors" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1007988) /Source="Nicolas_upshifts" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1007989..1008008 /Source="Nicolas_upshift_promotors" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1007990 /Source="Nicolas_upshifts" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1008003..1008004) /Source="Nicolas_upshift_promotors" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1008021..1008027 /Source="Nicolas_upshift_promotors" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1008042..1008053 /Source="Nicolas_upshift_promotors" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1008047 /Source="Nicolas_upshifts" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="upshifts" CDS 1008076..1010220 /gene="pbpF" /locus_tag="BSU_10110" /old_locus_tag="BSU10110" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8335642, 11567005, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8335642, 11567005, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 2C (1F class) required for spore germination" /protein_id="NP_388892.2" /db_xref="EnsemblGenomes-Gn:BSU10110" /db_xref="EnsemblGenomes-Tr:CAB12851" /db_xref="GOA:P38050" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10428" /db_xref="UniProtKB/Swiss-Prot:P38050" /translation="MFKIKKKKLFIPIIILVLTAFLALIGYISIIFLGHYVIDEKKLI LHASSKIVDQNGDEVASLYTENREPVSINEIPKQVREAFIAVEDKRFYEHHGIDAKSV GRAVYRDILAGGKVEGGSTITQQLAKNIFLTHDKTFLRKTKEVIIAINLERDYSKDKL LEMYLNQLYFGHGVYGIQAASHYYFNKEVKDLTVSEGAVLAAIPKAPSTYSPILHPDK NKERRDTILGMMNDQGYISAKEAVTAQGRTLGLHVKKQSETPWFDSYIDLVIKEAEDK YSISGEQLLQGGYTIKVPLDSKLQKTAYQVMKEGSYYPGTDQNAEGSAVFINNKTGGV EAAIGGRDYTSKGYNRVTAVRQPGSTFKPLAVYGPAMQEKKFKPYSLLKDELQSYGDY TPKNYDSRYEGEVTMSDAITYSKNAPAVWTLNEIGVETGKSYLKANGIDIPDEGLALA LGGLEKGVSPLQLAGAFHTFAANGTYTEPFFISSIIDEDGETIADHKEEGKRVFSKQT SWNMTRMLQQVVKKGTATSGTYHGDLAGKTGSTSYTGVSGATKDAWFAGYTPKITGAV WMGYDKTDQNHYLKAGSSYPTRLFKDILTQAGETGHVFTKPKNVKELESPIELKPVKT LTADYTFKAAGLFTIELKWDAQEDDRAVYRIYVNKDGEETLLDSVEGKGSYEIPYANL FSGASYKIVPYNTQTKREGEGTDYVQPKLFSS*" /label="pbpF CDS" gene 1008076..1010220 /gene="pbpF" /locus_tag="BSU_10110" /old_locus_tag="BSU10110" /label="pbpF gene" promotor_-10 complement(1008120..1008131) /Source="Nicolas_upshift_promotors" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1008123) /Source="Nicolas_upshifts" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1008145..1008151) /Source="Nicolas_upshift_promotors" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1010257..1010263 /Source="Nicolas_upshift_promotors" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1010277..1010296 /Source="Nicolas_upshift_promotors" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1010287 /Source="Nicolas_upshifts" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="upshifts" CDS 1010342..1011403 /gene="hemE" /locus_tag="BSU_10120" /old_locus_tag="BSU10120" /EC_number="4.1.1.37" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10217486, 17122346" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217486, 17122346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III decarboxylase" /protein_id="NP_388893.1" /db_xref="EnsemblGenomes-Gn:BSU10120" /db_xref="EnsemblGenomes-Tr:CAB12852" /db_xref="GOA:P32395" /db_xref="InterPro:IPR000257" /db_xref="InterPro:IPR006361" /db_xref="PDB:2INF" /db_xref="SubtiList:BG10429" /db_xref="UniProtKB/Swiss-Prot:P32395" /translation="MSKRETFNETFLKAARGEKADHTPVWYMRQAGRSQPEYRKLKEK YGLFEITHQPELCAYVTRLPVEQYGVDAAILYKDIMTPLPSIGVDVEIKNGIGPVIDQ PIRSLADIEKLGQIDPEQDVPYVLETIKLLVNEQLNVPLIGFSGAPFTLASYMIEGGP SKNYNKTKAFMYSMPDAWNLLMSKLADMIIVYVKAQIEAGAKAIQIFDSWVGALNQAD YRTYIKPVMNRIFSELAKENVPLIMFGVGASHLAGDWHDLPLDVVGLDWRLGIDEARS KGITKTVQGNLDPSILLAPWEVIEQKTKEILDQGMESDGFIFNLGHGVFPDVSPEVLK KLTAFVHEYSQNKKMGQYS*" /label="hemE CDS" gene 1010342..1011403 /gene="hemE" /locus_tag="BSU_10120" /old_locus_tag="BSU10120" /label="hemE gene" CDS 1011475..1012407 /gene="hemH" /locus_tag="BSU_10130" /old_locus_tag="BSU10130" /EC_number="4.99.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8119288, 12686546, 12761666, 16140324, 16453119, 17198378, 20543190, 21052751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8119288, 12686546, 12761666, 16140324, 16453119, 17198378, 20543190, 21052751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ferrochelatase" /protein_id="NP_388894.1" /db_xref="EnsemblGenomes-Gn:BSU10130" /db_xref="EnsemblGenomes-Tr:CAB12853" /db_xref="GOA:P32396" /db_xref="InterPro:IPR001015" /db_xref="InterPro:IPR019772" /db_xref="InterPro:IPR033644" /db_xref="InterPro:IPR033659" /db_xref="PDB:1AK1" /db_xref="PDB:1C1H" /db_xref="PDB:1C9E" /db_xref="PDB:1DOZ" /db_xref="PDB:1FJI" /db_xref="PDB:1LD3" /db_xref="PDB:1N0I" /db_xref="PDB:2AC2" /db_xref="PDB:2AC4" /db_xref="PDB:2H1V" /db_xref="PDB:2H1W" /db_xref="PDB:2HK6" /db_xref="PDB:2Q2N" /db_xref="PDB:2Q2O" /db_xref="PDB:2Q3J" /db_xref="PDB:3GOQ" /db_xref="PDB:3M4Z" /db_xref="SubtiList:BG10430" /db_xref="UniProtKB/Swiss-Prot:P32396" /translation="MSRKKMGLLVMAYGTPYKEEDIERYYTHIRRGRKPEPEMLQDLK DRYEAIGGISPLAQITEQQAHNLEQHLNEIQDEITFKAYIGLKHIEPFIEDAVAEMHK DGITEAVSIVLAPHFSTFSVQSYNKRAKEEAEKLGGLTITSVESWYDEPKFVTYWVDR VKETYASMPEDERENAMLIVSAHSLPEKIKEFGDPYPDQLHESAKLIAEGAGVSEYAV GWQSEGNTPDPWLGPDVQDLTRDLFEQKGYQAFVYVPVGFVADHLEVLYDNDYECKVV TDDIGASYYRPEMPNAKPEFIDALATVVLKKLGR*" /label="hemH CDS" gene 1011475..1012407 /gene="hemH" /locus_tag="BSU_10130" /old_locus_tag="BSU10130" /label="hemH gene" CDS 1012422..1013834 /gene="hemY" /locus_tag="BSU_10140" /old_locus_tag="BSU10140" /EC_number="1.3.3.4" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9217019, 9784236, 10498703, 20543190" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9217019, 9784236, 10498703, 20543190; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous protoporphyrinogen IX and coproporphyrinogen III oxidase" /protein_id="NP_388895.1" /db_xref="EnsemblGenomes-Gn:BSU10140" /db_xref="EnsemblGenomes-Tr:CAB12854" /db_xref="GOA:P32397" /db_xref="InterPro:IPR002937" /db_xref="InterPro:IPR004572" /db_xref="InterPro:IPR036188" /db_xref="PDB:3I6D" /db_xref="SubtiList:BG10431" /db_xref="UniProtKB/Swiss-Prot:P32397" /translation="MSDGKKHVVIIGGGITGLAAAFYMEKEIKEKNLPLELTLVEASP RVGGKIQTVKKDGYIIERGPDSFLERKKSAPQLVKDLGLEHLLVNNATGQSYVLVNRT LHPMPKGAVMGIPTKIAPFVSTGLFSLSGKARAAMDFILPASKTKDDQSLGEFFRRRV GDEVVENLIEPLLSGIYAGDIDKLSLMSTFPQFYQTEQKHRSLILGMKKTRPQGSGQQ LTAKKQGQFQTLSTGLQTLVEEIEKQLKLTKVYKGTKVTKLSHSGSCYSLELDNGVTL DADSVIVTAPHKAAAGMLSELPAISHLKNMHSTSVANVALGFPEGSVQMEHEGTGFVI SRNSDFAITACTWTNKKWPHAAPEGKTLLRAYVGKAGDESIVDLSDNDIINIVLEDLK KVMNINGEPEMTCVTRWHESMPQYHVGHKQRIKELREALASAYPGVYMTGASFEGVGI PDCIDQGKAAVSDALTYLFS*" /label="hemY CDS" gene 1012422..1013834 /gene="hemY" /locus_tag="BSU_10140" /old_locus_tag="BSU10140" /label="hemY gene" downshifts 1012425 /Source="Nicolas_upshifts" /id="D550" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="7.68191" /MaxDrop="2.667" /score="28.7532434" /energy="-11.6" /TU="U813,U816" /idTUdmin="U814" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1013811 /Source="Nicolas_upshifts" /id="D551" /incds=0 /nref=195 /ntot=254 /MaxReadThrough="2.9859" /MaxDrop="6.7703" /score="28.7532434" /energy="-11.6" /TU="NA" /idTUdmin="U813" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1013895..1013902 /Source="Nicolas_upshift_promotors" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1013916..1013935 /Source="Nicolas_upshift_promotors" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1013921 /Source="Nicolas_upshifts" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="upshifts" CDS 1013980..1014555 /gene="yhgD" /locus_tag="BSU_10150" /old_locus_tag="BSU10150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15944459, 23695570; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of unknown target" /protein_id="NP_388896.1" /db_xref="EnsemblGenomes-Gn:BSU10150" /db_xref="EnsemblGenomes-Tr:CAB12855" /db_xref="GOA:P32398" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG10432" /db_xref="UniProtKB/Swiss-Prot:P32398" /translation="MSIDRKKLILEAATKSFTQFGYKATTMDLVAKLANVGKGTIYTF FKNKEELFDEIFTTLLKEMKQKADEAMEPSLPFHENVHRALFAILEFRKTHQLTIKIF QENAEIGTMAVQEVIQKMERSILSYIKSKIEDGIKSGAIKPCDPELTAFVMLKLYIAL IFDWEKQHPPLDKETIAGLLELYVVKGLSAN*" /label="yhgD CDS" gene 1013980..1014555 /gene="yhgD" /locus_tag="BSU_10150" /old_locus_tag="BSU10150" /label="yhgD gene" promotor_-35 1014299..1014302 /Source="Nicolas_upshift_promotors" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1014317 /Source="Nicolas_upshifts" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1014319..1014338 /Source="Nicolas_upshift_promotors" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1014556..1014625 /Source="Nicolas_S_feature" /locus_tag="new_1090331_1090400" /HighExp="G135, G150, G180, BI, Salt, Etha, Cold, Heat, Oxctl, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.731, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S358" CDS 1014626..1016953 /gene="yhgE" /locus_tag="BSU_10160" /old_locus_tag="BSU10160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15576783; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative methyl-accepting protein" /protein_id="NP_388897.1" /db_xref="EnsemblGenomes-Gn:BSU10160" /db_xref="EnsemblGenomes-Tr:CAB12856" /db_xref="GOA:P32399" /db_xref="InterPro:IPR017500" /db_xref="InterPro:IPR017501" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR023908" /db_xref="SubtiList:BG10433" /db_xref="UniProtKB/Swiss-Prot:P32399" /translation="MNTIRSQWKDIVTSKKLLIPIIAILFVPLIYSGVFLKAYWDPYG TVDQLPVVVVNQDKGATYEGEKLQIGDDLVKELKDNNNFDWHFSNDLDQSLKDLLNQK YYLVVEIPEDFSKNASTVLDKNPKKLDLKYHTNAGSNYVGATIGEKAIDKLKASVSKE VTEQYTKVIFDNFKDIAKGLSDASSGAKKIDDGTKDAKNGSAQLKENLAKLKESTATI SDKTAQLADGAAQVTSGIQSLDSSLGKFQDSSNQIYDKSSQLAAGSGELTSKMNELLA GLQNVQKGTPNLTNGLDQLNSKVQEGSEKAAKAEKIINALDLTKLETAVNNLEKSETA MKEFKKQLTDFENSLKNRDQAFKNVINSSDFLTAEQKSQLINSVEKKLPQVDAPDFDQ ILSQLPTADQLPDIATIKSSLEDVKAQVAQVKAMPEATSKLYNGAKTIQDAIDRLTEG ADKIYNGSQKLTDGQTKLTAGIGEYNKQFAKAKAGSEQLVTGSSQVSGGLFKLLDGSK QVQSGSSKLADGSASLDTGLGKLLDGTGELSSKLKDAADQTGDIDADDQTYGMFADPV KTKDDAIHSVPNYGTGLTPYILSMGLYVGGIMLTVVFPLKEASGRPRNGFEWFFSKFN VMMLVGIIQSLIVATVLLLGIGLEVESTWRFYVFTIITSLAFLAIIQFLATTMGNPGR FIAVIILVLQLGASGGTFPLELLPNFYQVIHGALPMTYSINGFRAVISNGDFGYMWQM AGVLIGIALVMIALSITYFTMLSRKEETSEEQPAS*" /label="yhgE CDS" gene 1014626..1016953 /gene="yhgE" /locus_tag="BSU_10160" /old_locus_tag="BSU10160" /label="yhgE gene" downshifts 1016935 /Source="Nicolas_upshifts" /id="D552" /incds=0 /nref=65 /ntot=211 /MaxReadThrough="0.57274" /MaxDrop="5.58483" /score="-4.79013797" /energy="-7.3" /TU="NA" /idTUdmin="U817" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1016995..1017972) /gene="fabHB" /locus_tag="BSU_10170" /old_locus_tag="BSU10170" /EC_number="2.3.1.180" /EC_number="2.3.1.38" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10629181, 21383089, 21542858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629181, 21383089, 21542858; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase III 2" /protein_id="NP_388898.1" /db_xref="EnsemblGenomes-Gn:BSU10170" /db_xref="EnsemblGenomes-Tr:CAB12857" /db_xref="GOA:O07600" /db_xref="InterPro:IPR004655" /db_xref="InterPro:IPR013747" /db_xref="InterPro:IPR013751" /db_xref="InterPro:IPR016039" /db_xref="SubtiList:BG13048" /db_xref="UniProtKB/Swiss-Prot:O07600" /translation="MSKAKITAIGTYAPSRRLTNADLEKIVDTSDEWIVQRTGMRERR IADEHQFTSDLCIEAVKNLKSRYKGTLDDVDMILVATTTSDYAFPSTACRVQEYFGWE STGALDINATCAGLTYGLHLANGLITSGLHQKILVIAGETLSKVTDYTDRTTCVLFGD AAGALLVERDEETPGFLASVQGTSGNGGDILYRAGLRNEINGVQLVGSGKMVQNGREV YKWAARTVPGEFERLLHKAGLSSDDLDWFVPHSANLRMIESICEKTPFPIEKTLTSVE HYGNTSSVSIVLALDLAVKAGKLKKDQIVLLFGFGGGLTYTGLLIKWGM*" /label="fabHB CDS" gene complement(1016995..1017972) /gene="fabHB" /locus_tag="BSU_10170" /old_locus_tag="BSU10170" /label="fabHB gene" downshifts complement(1017008) /Source="Nicolas_upshifts" /id="D553" /incds=0 /nref=21 /ntot=217 /MaxReadThrough="1.99012" /MaxDrop="7.90433" /score="-9.17544275" /energy="-7.3" /TU="NA" /idTUdmin="U819" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1017986..1018005) /Source="Nicolas_upshift_promotors" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1018004) /Source="Nicolas_upshifts" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1018019..1018025) /Source="Nicolas_upshift_promotors" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1018031..1018039 /Source="Nicolas_upshift_promotors" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1018050..1018068 /Source="Nicolas_upshift_promotors" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1018057 /Source="Nicolas_upshifts" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="upshifts" CDS 1018099..1018875 /gene="yhfC" /locus_tag="BSU_10180" /old_locus_tag="BSU10180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388899.1" /db_xref="EnsemblGenomes-Gn:BSU10180" /db_xref="EnsemblGenomes-Tr:CAB12858" /db_xref="GOA:O07601" /db_xref="InterPro:IPR011397" /db_xref="SubtiList:BG13049" /db_xref="UniProtKB/Swiss-Prot:O07601" /translation="MVSQEAVVFLALSGAIAFLLPIGLIVWFKRKYGASLKVFFIGAL TFFVFAQLLEGGVHVYVLQVNEMTKEAMQHPLWYGIYGCLMAGIFEECGRYLMMRFFM KRHHTWADGLAFGAGHGGLEAILITGLSSISLIVYAFAINSGTFEQLLVNGDVKQALL PIQEQLLHTPSYEWMLGGIERISAIAVQIGLSLLVLYAVKNRRPLFLLYSILLHALFN VPAVLYQRGIIEHAAAVEIIVALIAALSVYWIVKAKRVFQ*" /label="yhfC CDS" gene 1018099..1018875 /gene="yhfC" /locus_tag="BSU_10180" /old_locus_tag="BSU10180" /label="yhfC gene" S_feature complement(1018591..1019212) /Source="Nicolas_S_feature" /locus_tag="new_1094366_1094987_c" /HighExp="B36, BT, B60, Pyr, S8, G/S, G135, Mal, M/G, Glucon" /AntisenseName="yhfC" /AntisenseCor="-0.12937903461570099" /AntisenseRegPval="-1.5" /CDS_PredictionProba="0.51248700000000003" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S359" S_feature 1018876..1019247 /Source="Nicolas_S_feature" /locus_tag="new_1094651_1095022" /HighExp="Lbstat, S2, M0t90, M40t90, HiOs, SMMPr, T-2.40H, Etha, Lbtran, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.48518699999999998" /TUshortSig="SigH" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S360" promotor_-10 complement(1019190..1019209) /Source="Nicolas_upshift_promotors" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1019211) /Source="Nicolas_upshifts" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1019223..1019232) /Source="Nicolas_upshift_promotors" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1019225..1019232 /Source="Nicolas_upshift_promotors" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1019247..1019266 /Source="Nicolas_upshift_promotors" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1019249 /Source="Nicolas_upshifts" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="upshifts" CDS 1019288..1020328 /gene="yhfE" /locus_tag="BSU_10200" /old_locus_tag="BSU10200" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15713475, 15743956; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminopeptidase" /protein_id="NP_388901.1" /db_xref="EnsemblGenomes-Gn:BSU10200" /db_xref="EnsemblGenomes-Tr:CAB12860" /db_xref="GOA:O07603" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="SubtiList:BG13051" /db_xref="UniProtKB/Swiss-Prot:O07603" /translation="MTSVRKTMELIKELVSIPSPTGNTYEVINYIESLLKEWKVETVR NHKGGLIATLPGRDTSRHRMLTAHVDTLGAMVKEIKADGRLKIDLIGGFRYNSIEGEY CQIETASGKMYTGTILMHQTSVHVYKDAGKAERNQENMEIRLDEPVHCRKDTEELGIG VGDFVSFDPRVEITSSGFIKSRHLDDKASVALLLRLIHEIQTEDIELPYTTHFLISNN EEIGYGGNSNIPPETVEYLAVDMGAIGDGQATDEYSVSICVKDASGPYHYQLRKHLVQ LAEKHHIDYKLDIYPYYGSDASAAIKSGHDIVHGLIGPGIDASHAFERTHKSSLRHTA KLLYYYVQSPMV*" /label="yhfE CDS" gene 1019288..1020328 /gene="yhfE" /locus_tag="BSU_10200" /old_locus_tag="BSU10200" /label="yhfE gene" CDS 1020341..1020748 /gene="yhfF" /locus_tag="BSU_10210" /old_locus_tag="BSU10210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11157739, 14517985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-binding PUA-containing enzyme" /protein_id="NP_388902.1" /db_xref="EnsemblGenomes-Gn:BSU10210" /db_xref="EnsemblGenomes-Tr:CAB12861" /db_xref="InterPro:IPR007374" /db_xref="InterPro:IPR009326" /db_xref="InterPro:IPR015947" /db_xref="SubtiList:BG13052" /db_xref="UniProtKB/Swiss-Prot:O07604" /translation="MKIYKLKSTFGWEGDDGLGEQLIQQILAGEKSATCAPKSLYSKD ELRDVYQTAGQLVTVYDKHDNPRCNIKVTDVFETTFGAPDMRLVKGEGNGDRIEEFQE DHRMAWAELIKSGELELNEDTVLITELFVLVKD*" /label="yhfF CDS" gene 1020341..1020748 /gene="yhfF" /locus_tag="BSU_10210" /old_locus_tag="BSU10210" /label="yhfF gene" downshifts 1020719 /Source="Nicolas_upshifts" /id="D554" /incds=0 /nref=24 /ntot=228 /MaxReadThrough="0.87656" /MaxDrop="5.21108" /score="22.0862441" /energy="-20.3" /TU="U822" /idTUdmin="U822" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(1020785..1022074) /gene="gltT" /locus_tag="BSU_10220" /old_locus_tag="BSU10220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8634258, 10588697, 11148213, 15849754, 16850406, 17673229, 25344233" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8634258, 10588697, 11148213, 15849754, 16850406, 17673229, 25344233; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton/sodium-glutamate (aspartate) symport permease" /protein_id="NP_388903.1" /db_xref="EnsemblGenomes-Gn:BSU10220" /db_xref="EnsemblGenomes-Tr:CAB12862" /db_xref="GOA:O07605" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR033380" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG12595" /db_xref="UniProtKB/Swiss-Prot:O07605" /translation="MKRIKFGLATQIFVGLILGVIVGVIWYGNPALPTYLQPIGDLFL RLIKMIVIPIVVSSLIIGVAGAGNGKQVGKLGFRTILYFEIITTFAIILGLALANIFH PGTGVNIHEAQKSDISQYVETEKEQSNKSVAETFLHIVPTNFFQSLVEGDLLAIICFT VLFALGISAIGERGKPVLAFFEGVSHAMFHVVNLVMKVAPFGVFALIGVTVSKFGLGS LISLGKLVGLVYVALAFFLIVIFGIVAKIAGISIFKFLAYMKDEILLAFSTSSSETVL PRIMEKMEKIGCPKGIVSFVIPIGYTFNLDGSVLYQSIAALFLAQVYGIDLTIWHQIT LVLVLMVTSKGMAAVPGTSFVVLLATLGTIGVPAEGLAFIAGVDRIMDMARTVVNLTG NALAAVVMSKWEGMFNPAKAETVMSQSKTEQNATISG*" /label="gltT CDS" gene complement(1020785..1022074) /gene="gltT" /locus_tag="BSU_10220" /old_locus_tag="BSU10220" /label="gltT gene" downshifts complement(1020815) /Source="Nicolas_upshifts" /id="D555" /incds=0 /nref=226 /ntot=280 /MaxReadThrough="2.99263" /MaxDrop="7.79183" /score="48.7726082" /energy="-21.9" /TU="U823" /idTUdmin="U824" /TUdmin=3 /isTUend="TRUE" /label="downshifts" S_feature complement(1022075..1022175) /Source="Nicolas_S_feature" /locus_tag="new_1097850_1097950_c" /HighExp="C90, LoTm, LBGexp, Cold, UNK1, BC, dia5, Lbexp, S1, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S361" promotor_-10 complement(1022174..1022193) /Source="Nicolas_upshift_promotors" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1022175) /Source="Nicolas_upshifts" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1022177..1022313) /Source="Nicolas_S_feature" /locus_tag="new_1097952_1098088_c" /HighExp="M9-stat, T3.30H, T3.0H, T4.0H, T2.30H, T5.0H, Cold, T2.0H, S0, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S362" promotor_-35 complement(1022208..1022214) /Source="Nicolas_upshift_promotors" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1022345..1022485) /gene="yhfH" /locus_tag="BSU_10230" /old_locus_tag="BSU10230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388904.1" /db_xref="EnsemblGenomes-Gn:BSU10230" /db_xref="EnsemblGenomes-Tr:CAB12863" /db_xref="InterPro:IPR025432" /db_xref="SubtiList:BG13053" /db_xref="UniProtKB/Swiss-Prot:O07606" /translation="MVMLGKITEFFRNLPSKKCAECGKKIEEQHECYGNICNDCIKVN DL*" /label="yhfH CDS" gene complement(1022345..1022485) /gene="yhfH" /locus_tag="BSU_10230" /old_locus_tag="BSU10230" /label="yhfH gene" downshifts complement(1022358) /Source="Nicolas_upshifts" /id="D556" /incds=0 /nref=3 /ntot=16 /MaxReadThrough="5.70702" /MaxDrop="4.73949" /score="28.7665297" /energy="-13.6" /TU="U824" /idTUdmin="U824" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1022504..1022523) /Source="Nicolas_upshift_promotors" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1022523) /Source="Nicolas_upshifts" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1022536..1022543) /Source="Nicolas_upshift_promotors" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1022567..1022573 /Source="Nicolas_upshift_promotors" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1022587..1022606 /Source="Nicolas_upshift_promotors" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1022590 /Source="Nicolas_upshifts" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="upshifts" CDS 1022637..1023371 /gene="yhfI" /locus_tag="BSU_10240" /old_locus_tag="BSU10240" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388905.1" /db_xref="EnsemblGenomes-Gn:BSU10240" /db_xref="EnsemblGenomes-Tr:CAB12864" /db_xref="GOA:O07607" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13054" /db_xref="UniProtKB/Swiss-Prot:O07607" /translation="MKVTVIGCYGGFPAANEATSGYLFQSGDYSLLVDCGSAVLSKLF GYVPAEKLDAVVLSHYHHDHIADIGPLQFAKQVGSFLGKGEHTLPIYGHDADIEQFQK LTYKTHTKGIAYQPDQPLTAGPFTITFLKTIHPVTCYAMRITDGSHTVVYTADSSYQD SFIPFSKDADLLISECNFYADQDGTSAGHMNSLEAGRIAKEAGAGELLLTHLPHFGVH DNLRKEAKTVFNGEVNIAKSGFVWEG*" /label="yhfI CDS" gene 1022637..1023371 /gene="yhfI" /locus_tag="BSU_10240" /old_locus_tag="BSU10240" /label="yhfI gene" CDS 1023384..1024379 /gene="lplJ" /locus_tag="BSU_10250" /old_locus_tag="BSU10250" /EC_number="6.3.1.20" /experiment="publication(s) with functional evidences, PMID:21338420, 21338421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21338420, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lipoate-protein ligase" /protein_id="NP_388906.1" /db_xref="EnsemblGenomes-Gn:BSU10250" /db_xref="EnsemblGenomes-Tr:CAB12865" /db_xref="GOA:O07608" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR004562" /db_xref="InterPro:IPR019491" /db_xref="SubtiList:BG13055" /db_xref="UniProtKB/Swiss-Prot:O07608" /translation="MLFIDNQNINDPRINLAIEEYCVKHLDPEQQYLLFYVNQPSIII GKNQNTIEEINTKYVEENGIIVVRRLSGGGAVYHDLGNLNFSFITKDDGDSFHNFKKF TEPVIQALHQLGVEAELSGRNDIVVDGRKISGNAQFATKGRIFSHGTLMFDSAIDHVV SALKVKKDKIESKGIKSIRSRVANISEFLDDKMTTEEFRSHLLRHIFNTNDVGNVPEY KLTEKDWETIHQISKERYQNWDWNYGRSPKFNLNHSKRYPVGSIDLHLEVKKGKIEDC KIFGDFFGVGDVSEIENLLVGKQYERSVIADVLEGVNLKHYFGNITKEDFLDLIY*" /label="lplJ CDS" gene 1023384..1024379 /gene="lplJ" /locus_tag="BSU_10250" /old_locus_tag="BSU10250" /label="lplJ gene" CDS 1024444..1025088 /gene="yhfK" /locus_tag="BSU_10260" /old_locus_tag="BSU10260" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11790741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-binding epimerase / hydratase" /protein_id="NP_388907.1" /db_xref="EnsemblGenomes-Gn:BSU10260" /db_xref="EnsemblGenomes-Tr:CAB12866" /db_xref="GOA:O07609" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13056" /db_xref="UniProtKB/Swiss-Prot:O07609" /translation="MKVFLIGANGQIGQRLVSLFQDNPDHSIRAMVRKEEQKASLEAA GAEAVLANLEGSPEEIAAAAKGCDAIIFTAGSGGSTGYDKTLLVDLDGAAKAIEAAAI AGIKRFIMVSALQAHNRENWNEALKPYYVAKHYADKILEASGLTYTIIRPGGLRNEPG TGTVSAAKDLERGFISRDDVAKTVIASLDEKNTENRAFDLTEGDTPIAEALKKL*" /label="yhfK CDS" gene 1024444..1025088 /gene="yhfK" /locus_tag="BSU_10260" /old_locus_tag="BSU10260" /label="yhfK gene" downshifts 1025076 /Source="Nicolas_upshifts" /id="D557" /incds=0 /nref=239 /ntot=258 /MaxReadThrough="0.56809" /MaxDrop="6.84076" /score="18.2092404" /energy="-10" /TU="NA" /idTUdmin="U825" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1025116..1025119 /Source="Nicolas_upshift_promotors" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1025134..1025153 /Source="Nicolas_upshift_promotors" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1025141 /Source="Nicolas_upshifts" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="upshifts" CDS 1025205..1026746 /gene="lcfB" /locus_tag="BSU_10270" /old_locus_tag="BSU10270" /EC_number="6.2.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="long-chain fatty-acid-CoA ligase (degradative)" /protein_id="NP_388908.2" /db_xref="EnsemblGenomes-Gn:BSU10270" /db_xref="EnsemblGenomes-Tr:CAB12867" /db_xref="GOA:O07610" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020459" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13057" /db_xref="UniProtKB/Swiss-Prot:O07610" /translation="MNLVSKLEETASEKPDSIACRFKDHMMTYQELNEYIQRFADGLQ EAGMEKGDHLALLLGNSPDFIIAFFGALKAGIVVVPINPLYTPTEIGYMLTNGDVKAI VGVSQLLPLYESMHESLPKVELVILCQTGEAEPEAADPEVRMKMTTFAKILRPTSAAK QNQEPVPDDTAVILYTSGTTGKPKGAMLTHQNLYSNANDVAGYLGMDERDNVVCALPM FHVFCLTVCMNAPLMSGATVLIEPQFSPASVFKLVKQQQATIFAGVPTMYNYLFQHEN GKKDDFSSIRLCISGGASMPVALLTAFEEKFGVTILEGYGLSEASPVTCFNPFDRGRK PGSIGTSILHVENKVVDPLGRELPAHQVGELIVKGPNVMKGYYKMPMETEHALKDGWL YTGDLARRDEDGYFYIVDRKKDMIIVGGYNVYPREVEEVLYSHPDVKEAVVIGVPDPQ SGEAVKGYVVPKRSGVTEEDIMQHCEKHLAKYKRPAAITFLDDIPKNATGKMLRRALR DILPQ*" /label="lcfB CDS" gene 1025205..1026746 /gene="lcfB" /locus_tag="BSU_10270" /old_locus_tag="BSU10270" /label="lcfB gene" downshifts 1026726 /Source="Nicolas_upshifts" /id="D558" /incds=0 /nref=5 /ntot=108 /MaxReadThrough="2.74134" /MaxDrop="3.72638" /score="15.3712924" /energy="-10.4" /TU="NA" /idTUdmin="U826" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1026785..1027180) /gene="yhfM" /locus_tag="BSU_10280" /old_locus_tag="BSU10280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388909.1" /db_xref="EnsemblGenomes-Gn:BSU10280" /db_xref="EnsemblGenomes-Tr:CAB12868" /db_xref="SubtiList:BG13058" /db_xref="UniProtKB/Swiss-Prot:O07611" /translation="MKKIVAAIVVIGLVFIAFFYLYSRSGDVYQSVDADLITLSSSGQ EDIEIEKRQHVKDMLDIMNQGKQVKTEKTSAPDYEGTIKFHKDRYDSFRLWIDGSQQA VFLKDGTYYKLSKNDTKALLNIIKKEAKD*" /label="yhfM CDS" gene complement(1026785..1027180) /gene="yhfM" /locus_tag="BSU_10280" /old_locus_tag="BSU10280" /label="yhfM gene" downshifts complement(1026802) /Source="Nicolas_upshifts" /id="D559" /incds=0 /nref=46 /ntot=89 /MaxReadThrough="0.75539" /MaxDrop="6.88759" /score="17.4775611" /energy="-10.4" /TU="NA" /idTUdmin="U827" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1027200..1027211) /Source="Nicolas_upshift_promotors" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1027204) /Source="Nicolas_upshifts" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1027226..1027232) /Source="Nicolas_upshift_promotors" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1027265..1027268 /Source="Nicolas_upshift_promotors" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1027276 /Source="Nicolas_upshifts" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1027283..1027302 /Source="Nicolas_upshift_promotors" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1027329..1028609 /gene="yhfN" /locus_tag="BSU_10290" /old_locus_tag="BSU10290" /EC_number="3.4.24.84" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9015299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane metalloprotease" /protein_id="NP_388910.1" /db_xref="EnsemblGenomes-Gn:BSU10290" /db_xref="EnsemblGenomes-Tr:CAB12869" /db_xref="GOA:P40769" /db_xref="InterPro:IPR001915" /db_xref="InterPro:IPR027057" /db_xref="InterPro:IPR032456" /db_xref="SubtiList:BG11029" /db_xref="UniProtKB/Swiss-Prot:P40769" /translation="MRKWIAAAGLAYVLYGLFFYWYFFLSGDSAIPEAVKGTQADPAS FMKPSELAVAEQYSNVKNFLFFIGVPLDWFLFFVLLVSGVSKKIKKWIEAAVPFRFLQ TVGFVFVLSLITTLVTLPLDWIGYQVSLDYNISTQTTASWAKDQVISFWISFPIFTLC VLVFYWLIKRHEKKWWLYAWLLTVPFSLFLFFIQPVIIDPLYNDFYPLKNKELESKIL ELADEANIPADHVYEVNMSEKTNALNAYVTGIGANKRIVLWDTTLNKLDDSEILFIMG HEMGHYVMKHVYIGLAGYLLVSLAGFYVIDKLYKRTVRLTRSMFHLEGRHDLAALPLL LLLFSVLSFAVTPFSNAVSRYQENKADQYGIELTENREAAVKTFQDLAVTGLSQVDPP VLVKIFRGSHPSIMERIQHAEKEENAPEHQDADK*" /label="yhfN CDS" gene 1027329..1028609 /gene="yhfN" /locus_tag="BSU_10290" /old_locus_tag="BSU10290" /label="yhfN gene" promotor_-10 complement(1027756..1027775) /Source="Nicolas_upshift_promotors" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1027770) /Source="Nicolas_upshifts" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1027791..1027796) /Source="Nicolas_upshift_promotors" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1028596 /Source="Nicolas_upshifts" /id="D560" /incds=0 /nref=2 /ntot=57 /MaxReadThrough="3.82026" /MaxDrop="3.6342" /score="6.45541384" /energy="-12.7" /TU="U828" /idTUdmin="U828" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts complement(1028646) /Source="Nicolas_upshifts" /id="D561" /incds=0 /nref=129 /ntot=219 /MaxReadThrough="-0.11848" /MaxDrop="9.02627" /score="-6.76069514" /energy="-7.8" /TU="NA" /idTUdmin="U830" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(1028648..1029793) /gene="aprE" /locus_tag="BSU_10300" /old_locus_tag="BSU10300" /EC_number="3.4.21.62" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3108260, 9811547, 12950930, 14688235, 15205417, 17666034, 19710937, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3108260, 9811547, 12950930, 14688235, 15205417, 17666034, 19710937, 26728191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine alkaline protease (Ca(2+)-dependent subtilisin E)" /protein_id="NP_388911.2" /db_xref="EnsemblGenomes-Gn:BSU10300" /db_xref="EnsemblGenomes-Tr:CAB12870" /db_xref="GOA:P04189" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR009020" /db_xref="InterPro:IPR010259" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034202" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="PDB:1SCJ" /db_xref="PDB:3WHI" /db_xref="SubtiList:BG10190" /db_xref="UniProtKB/Swiss-Prot:P04189" /translation="MRSKKLWISLLFALTLIFTMAFSNMSAQAAGKSSTEKKYIVGFK QTMSAMSSAKKKDVISEKGGKVQKQFKYVNAAAATLDEKAVKELKKDPSVAYVEEDHI AHEYAQSVPYGISQIKAPALHSQGYTGSNVKVAVIDSGIDSSHPDLNVRGGASFVPSE TNPYQDGSSHGTHVAGTIAALNNSIGVLGVAPSASLYAVKVLDSTGSGQYSWIINGIE WAISNNMDVINMSLGGPTGSTALKTVVDKAVSSGIVVAAAAGNEGSSGSTSTVGYPAK YPSTIAVGAVNSSNQRASFSSAGSELDVMAPGVSIQSTLPGGTYGAYNGTSMATPHVA GAAALILSKHPTWTNAQVRDRLESTATYLGNSFYYGKGLINVQAAAQ*" /label="aprE CDS" gene complement(1028648..1029793) /gene="aprE" /locus_tag="BSU_10300" /old_locus_tag="BSU10300" /label="aprE gene" S_feature complement(1029794..1029860) /Source="Nicolas_S_feature" /locus_tag="new_1105569_1105635_c" /HighExp="BC, T5.0H, LoTm, Sw, T4.0H, T3.30H, S1, T3.0H, S2, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S363" promotor_-10 complement(1029849..1029868) /Source="Nicolas_upshift_promotors" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1029866) /Source="Nicolas_upshifts" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1029884..1029888) /Source="Nicolas_upshift_promotors" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1030173..1030180 /Source="Nicolas_upshift_promotors" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" /label="promotor_-35" promotor_-10 1030195..1030214 /Source="Nicolas_upshift_promotors" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" /label="promotor_-10" upshifts 1030197 /Source="Nicolas_upshifts" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" /label="upshifts" CDS 1030228..1030677 /gene="yhfO" /locus_tag="BSU_10310" /old_locus_tag="BSU10310" /EC_number="2.3.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388912.1" /db_xref="EnsemblGenomes-Gn:BSU10310" /db_xref="EnsemblGenomes-Tr:CAB12871" /db_xref="GOA:O07614" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13059" /db_xref="UniProtKB/Swiss-Prot:O07614" /translation="MNIRQAKTSDAAAIAPLFNQYREFYRQASDLQGAEAFLKARLEN HESVILIAEENGEFIGFTQLYPTFSSVSMKRIYILNDLFVVPHARTKGAGGRLLSAAK DYAGQNGAKCLTLQTEHHNRKARSLYEQNGYEEDTGFVHYCLNVPAK*" /label="yhfO CDS" gene 1030228..1030677 /gene="yhfO" /locus_tag="BSU_10310" /old_locus_tag="BSU10310" /label="yhfO gene" promotor_-35 1030693..1030700 /Source="Nicolas_upshift_promotors" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1030715..1030734 /Source="Nicolas_upshift_promotors" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1030722 /Source="Nicolas_upshifts" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1030749..1031741 /gene="yhfP" /locus_tag="BSU_10320" /old_locus_tag="BSU10320" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9643546, 12057962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388913.1" /db_xref="EnsemblGenomes-Gn:BSU10320" /db_xref="EnsemblGenomes-Tr:CAB12872" /db_xref="GOA:O07615" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR014188" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="PDB:1TT7" /db_xref="PDB:1Y9E" /db_xref="SubtiList:BG13060" /db_xref="UniProtKB/Swiss-Prot:O07615" /translation="MSTLFQALQAEKNADDVSVHVKTISTEDLPKDGVLIKVAYSGIN YKDGLAGKAGGNIVREYPLILGIDAAGTVVSSNDPRFAEGDEVIATSYELGVSRDGGL SEYASVPGDWLVPLPQNLSLKEAMVYGTAGFTAALSVHRLEQNGLSPEKGSVLVTGAT GGVGGIAVSMLNKRGYDVVASTGNREAADYLKQLGASEVISREDVYDGTLKALSKQQW QGAVDPVGGKQLASLLSKIQYGGSVAVSGLTGGGEVPATVYPFILRGVSLLGIDSVYC PMDVRAAVWERMSSDLKPDQLLTIVDREVSLEETPGALKDILQNRIQGRVIVKL*" /label="yhfP CDS" gene 1030749..1031741 /gene="yhfP" /locus_tag="BSU_10320" /old_locus_tag="BSU10320" /label="yhfP gene" downshifts 1031742 /Source="Nicolas_upshifts" /id="D562" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="4.4421" /MaxDrop="2.9095" /score="14.183693" /energy="-15.3" /TU="U831,U832" /idTUdmin="U831" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" S_feature 1031787..1031897 /Source="Nicolas_S_feature" /locus_tag="new_1107562_1107672" /HighExp="Etha, dia15, LoTm, Salt, H2O2, LBGexp, Diami, Paraq, dia5, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S364" promotor_-35 1031875..1031882 /Source="Nicolas_upshift_promotors" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1031898..1031917 /Source="Nicolas_upshift_promotors" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1031899 /Source="Nicolas_upshifts" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1031958..1032929 /gene="yhfQ" /locus_tag="BSU_10330" /old_locus_tag="BSU10330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16672620, 20147287; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron(III) siderophore-binding lipoprotein" /protein_id="NP_388914.2" /db_xref="EnsemblGenomes-Gn:BSU10330" /db_xref="EnsemblGenomes-Tr:CAB12873" /db_xref="GOA:C0SP94" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG13061" /db_xref="UniProtKB/Swiss-Prot:C0SP94" /translation="MKKTLIILTVLLLSVLTAACSSSSGNQNSKEHKVAVTHDLGKTN VPEHPKRVVVLELGFIDTLLDLGITPVGVADDNKAKQLINKDVLKKIDGYTSVGTRSQ PSMEKIASLKPDLIIADTTRHKKVYDQLKKIAPTIALNNLNADYQDTIDASLTIAKAV GKEKEMEKKLTAHEEKLSETKQKISANSQSVLLIGNTNDTIMARDENFFTSRLLTQVG YRYAISTSGNSDSSNGGDSVNMKMTLEQLLKTDPDVIILMTGKTDDLDADGKRPIEKN VLWKKLKAVKNGHVYHVDRAVWSLRRSVDGANAILDELQKEMPAAKK*" /label="yhfQ CDS" gene 1031958..1032929 /gene="yhfQ" /locus_tag="BSU_10330" /old_locus_tag="BSU10330" /label="yhfQ gene" downshifts 1032908 /Source="Nicolas_upshifts" /id="D563" /incds=0 /nref=172 /ntot=251 /MaxReadThrough="2.22013" /MaxDrop="5.6726" /score="27.9181244" /energy="-10.9" /TU="NA" /idTUdmin="U833" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1032961..1033542) /gene="phoE" /locus_tag="BSU_10340" /old_locus_tag="BSU10340" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10869096, 11827481, 12870714, 17693564" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869096, 11827481, 12870714, 17693564; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphatase; putative (phosphoglycerate) mutase" /protein_id="NP_388915.1" /db_xref="EnsemblGenomes-Gn:BSU10340" /db_xref="EnsemblGenomes-Tr:CAB12874" /db_xref="GOA:O07617" /db_xref="InterPro:IPR001345" /db_xref="InterPro:IPR013078" /db_xref="InterPro:IPR029033" /db_xref="SubtiList:BG13062" /db_xref="UniProtKB/Swiss-Prot:O07617" /translation="MTAVCLVRHGETDWNLQQKCQGKTDIPLNATGERQARETGEYVK DFSWDIIVTSPLKRAKRTAEIINEYLHLPIVEMDDFKERDYGDAEGMPLEERTKRYPD NIYPNMETLEELTDRLMGGLAKVNQAYPNKKVLIVAHGAAIHALLTEISGGDPELQST RLVNACLSNIEFAEEKWRIKDYNINSHLSGFIK*" /label="phoE CDS" gene complement(1032961..1033542) /gene="phoE" /locus_tag="BSU_10340" /old_locus_tag="BSU10340" /label="phoE gene" downshifts complement(1032984) /Source="Nicolas_upshifts" /id="D564" /incds=0 /nref=218 /ntot=256 /MaxReadThrough="1.23197" /MaxDrop="6.359" /score="28.9228703" /energy="-10.9" /TU="NA" /idTUdmin="U834" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1033566..1033585) /Source="Nicolas_upshift_promotors" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1033578) /Source="Nicolas_upshifts" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1033601..1033604) /Source="Nicolas_upshift_promotors" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1033613..1034707) /gene="yhfS" /locus_tag="BSU_10350" /old_locus_tag="BSU10350" /EC_number="2.3.1.9" /experiment="publication(s) with functional evidences, PMID:12368242, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12368242, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA C-acetyltransferase" /protein_id="NP_388916.1" /db_xref="EnsemblGenomes-Gn:BSU10350" /db_xref="EnsemblGenomes-Tr:CAB12875" /db_xref="GOA:O07618" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="SubtiList:BG13063" /db_xref="UniProtKB/Swiss-Prot:O07618" /translation="MNAVIVDAKRTIFGNQNGLLKPFLPEDLAAPIIRCLSRKLEDQV DEVILGNATGRGGNLARLSALQAGLPLSVPGMTIDRQCGSGLEAVRYACSLIQAGAGT MYIAGGSESSSQSPFSERARFSPDAIGDPDMGIAAEYTAARYSISRSMQDEYALLSHQ RSRNAHDEGFYREEVVALGELETDEAFLKTRPIEAIIPRAKPVFDTSSGTVTAANSSG IADGAAALLVMEEEKAAALGLKPVLRFIGSAVSGIHPNFPPAAPVVAIRQLLHTHDVT PDDIDLFEINEAFAVKICVCSQELGIPFSKINVRGGALALGHPYGASGAALVTRLFYE AKRRPDCQYAVAAIGSGGGIGLALLFEVLA*" /label="yhfS CDS" gene complement(1033613..1034707) /gene="yhfS" /locus_tag="BSU_10350" /old_locus_tag="BSU10350" /label="yhfS gene" CDS complement(1034704..1036143) /gene="yhfT" /locus_tag="BSU_10360" /old_locus_tag="BSU10360" /EC_number="6.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12368242, 28032445, 28414710; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative long-chain fatty-acid-CoA ligase (proofreading for biotin synthesis)" /protein_id="NP_388917.1" /db_xref="EnsemblGenomes-Gn:BSU10360" /db_xref="EnsemblGenomes-Tr:CAB12876" /db_xref="GOA:O07619" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13064" /db_xref="UniProtKB/Swiss-Prot:O07619" /translation="MTITHTYSSTAETSPGRVAIQTESEQITYHDWDRLVSQTANWLR SQPSMPNRVAILLPNSLAFLQLFAGAAAAGCTAIPIDTRWSPAECKERLSISNADLVV TLAFFKNKLTDSQTPVVLLDNCMADISEAAADPLPTIDPEHPFYMGFTSGSTGKPKAF TRSHRSWMESFTCTETDFSISSDDKVLIPGALMSSHFLYGAVSTLFLGGTVCLLKKFS PAKAKEWLCRESISVLYTVPTMTDALARIEGFPDSPVKIISSGADWPAESKKKLAAAW PHLKLYDFYGTSELSFVTFSSPEDSKRKPHSAGRPFHNVRIEIRNAGGERCQPGEIGK IFVKSPMRFSGYVNGSTPDEWMTVDDMGYVDEEGFLYISGRENGMIVYGGLNIFPEEI ERVLLACPEVESAAVVGIPDEYWGEIAVAVILGNANARTLKAWCKQKLASYKIPKKWV FADSLPETSSGKIARSRVKKWLEESVQYK*" /label="yhfT CDS" gene complement(1034704..1036143) /gene="yhfT" /locus_tag="BSU_10360" /old_locus_tag="BSU10360" /label="yhfT gene" CDS complement(1036150..1036710) /gene="bioY" /locus_tag="BSU_10370" /old_locus_tag="BSU10370" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12368242, 15849754, 16850406, 18931129, 23709504; Product type t : transporter" /codon_start=1 /transl_table=11 /product="biotin transporter" /protein_id="NP_388918.1" /db_xref="EnsemblGenomes-Gn:BSU10370" /db_xref="EnsemblGenomes-Tr:CAB12877" /db_xref="GOA:O07620" /db_xref="InterPro:IPR003784" /db_xref="SubtiList:BG13065" /db_xref="UniProtKB/Swiss-Prot:O07620" /translation="MLKLIDMMHIAIFTALMAVLGFMPPLFLSFTPVPITLQTLGVML AGSILRPKSAFLSQLVFLLLVAFGAPLLPGGRGGFGVFFGPSAGFLIAYPLASWLISL AANRLRKVTVLRLFFTHIVFGIIFIYLLGIPVQAFIMHIDLSQAAFMSLAYVPGDLIK AAVSAFLAIKITQALSLSDTMFTKGG*" /label="bioY CDS" gene complement(1036150..1036710) /gene="bioY" /locus_tag="BSU_10370" /old_locus_tag="BSU10370" /label="bioY gene" misc_feature complement(1036160..1036179) /Source="Nicolas_upshift_promotors" /id="U835" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.585414585414585" /psig="0.97902097902098" /xcortree=2231 /SigmaFactorBS="aaaagcggctgtatctgcatttctggcgataaaaatcactca agccttgtctcttTCTGATACGATGTTTACAAAaggaggatgacaatacatgacaatt a" /listShort="yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1036174) /Source="Nicolas_upshifts" /id="U835" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.585414585414585" /psig="0.97902097902098" /xcortree=2231 /SigmaFactorBS="aaaagcggctgtatctgcatttctggcgataaaaatcactca agccttgtctcttTCTGATACGATGTTTACAAAaggaggatgacaatacatgacaatt a" /listShort="yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1036735..1036754) /Source="Nicolas_upshift_promotors" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1036749) /Source="Nicolas_upshifts" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1036769..1036776) /Source="Nicolas_upshift_promotors" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1036845..1038143) /gene="hemAT" /locus_tag="BSU_10380" /old_locus_tag="BSU10380" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11481493, 12657801, 12962628, 15033535, 16819829, 17003124, 22528495, 22564695" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11481493, 12657801, 12962628, 15033535, 16819829, 17003124, 22528495, 22564695; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="heme-based dioxygen sensor" /protein_id="NP_388919.1" /db_xref="EnsemblGenomes-Gn:BSU10380" /db_xref="EnsemblGenomes-Tr:CAB12878" /db_xref="GOA:O07621" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR009050" /db_xref="PDB:1OR4" /db_xref="PDB:1OR6" /db_xref="SubtiList:BG13066" /db_xref="UniProtKB/Swiss-Prot:O07621" /translation="MLFKKDRKQETAYFSDSNGQQKNRIQLTNKHADVKKQLKMVRLG DAELYVLEQLQPLIQENIVNIVDAFYKNLDHESSLMDIINDHSSVDRLKQTLKRHIQE MFAGVIDDEFIEKRNRIASIHLRIGLLPKWYMGAFQELLLSMIDIYEASITNQQELLK AIKATTKILNLEQQLVLEAFQSEYNQTRDEQEEKKNLLHQKIQETSGSIANLFSETSR SVQELVDKSEGISQASKAGTVTSSTVEEKSIGGKKELEVQQKQMNKIDTSLVQIEKEM VKLDEIAQQIEKIFGIVTGIAEQTNLLSLNASIESARAGEHGKGFAVVANEVRKLSED TKKTVSTVSELVNNTNTQINIVSKHIKDVNELVSESKEKMTQINRLFDEIVHSMKISK EQSGKIDVDLQAFLGGLQEVSRAVSHVAASVDSLVILTEE*" /label="hemAT CDS" gene complement(1036845..1038143) /gene="hemAT" /locus_tag="BSU_10380" /old_locus_tag="BSU10380" /label="hemAT gene" downshifts complement(1036856) /Source="Nicolas_upshifts" /id="D565" /incds=0 /nref=209 /ntot=243 /MaxReadThrough="2.70691" /MaxDrop="6.97357" /score="5.86442746" /energy="-6.9" /TU="NA" /idTUdmin="U837" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1038197..1038215) /Source="Nicolas_upshift_promotors" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1038200) /Source="Nicolas_upshifts" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1038229..1038235) /Source="Nicolas_upshift_promotors" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1038282..1039811) /gene="yhfW" /locus_tag="BSU_10390" /old_locus_tag="BSU10390" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase with Rieske [2Fe-2S] center" /protein_id="NP_388920.1" /db_xref="EnsemblGenomes-Gn:BSU10390" /db_xref="EnsemblGenomes-Tr:CAB12879" /db_xref="GOA:O07622" /db_xref="InterPro:IPR005805" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG13067" /db_xref="UniProtKB/Swiss-Prot:O07622" /translation="MANQHFAKEAPETYWKTSTDLPSFPALQEDTECDVTIIGGGITG ITTAYELTKRGFRVVLIEANQVLNGTTAHTTAKVTAQHDMIYDEFIRHFGLNHARLYY EANQNAIDYIKGIVDEHQIDCEWIEQDAYLYTANENAVQKIHTEHEAYTKLGIERDLI KDLPIPLGSKLALVMKNQAQFHPLQYLKALLEQIVQKGGRIYEETVALDIKKGERPEV VTKSRHAIKSRFIICCSHFPFYDGGGLYAARMYSDRSYVLAIKPKIEYPEGMYLSIDQ PSVALRYTVVNGEKLILFSGVSHKTGQGKAMSTHYETLRQLAESTIGIESIPYYWSTQ DLVTIDKIPFIGPMSENEDNILVATGFKKWGMTSSAVAATLLSDLVEKKENPYESIFT PSRFHLNPGLQKVISYNADVAKHLIKGKLEKPDVQFEDISPGEGKAVTINGRRAGAFR DETGCLHLVDTTCTHLGCEVEWNDSEHTWDCPCHGSRFKPSGEVVEGPAIKPLKQIDL D*" /label="yhfW CDS" gene complement(1038282..1039811) /gene="yhfW" /locus_tag="BSU_10390" /old_locus_tag="BSU10390" /label="yhfW gene" promotor_-10 complement(1039838..1039856) /Source="Nicolas_upshift_promotors" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1039848) /Source="Nicolas_upshifts" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1039867..1039872 /Source="Nicolas_upshift_promotors" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1039871..1039876) /Source="Nicolas_upshift_promotors" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1039884 /Source="Nicolas_upshifts" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1039888..1039906 /Source="Nicolas_upshift_promotors" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1039923..1040780 /gene="yhxC" /locus_tag="BSU_10400" /old_locus_tag="BSU10400" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18643936, 25720121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388921.1" /db_xref="EnsemblGenomes-Gn:BSU10400" /db_xref="EnsemblGenomes-Tr:CAB12880" /db_xref="GOA:P40397" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11058" /db_xref="UniProtKB/Swiss-Prot:P40397" /translation="MANQKKKTLPPQHQNQQPGFEYLMDPRPVFDKPKKAKKLEGKTA IITGGDSGIGRAVSVLFAKEGANVVIVYLNEHQDAEETKQYVEKEGVKCLLIAGDVGD EAFCNDVVGQASQVFPSIDILVNNAAEQHVQPSIEKITSHQLIRTFQTNIFSMFYLTK AVLPHLKKGSSIINTASITAYKGNKTLIDYSATKGAIVTFTRSLSQSLVQQGIRVNAV APGPIWTPLIPASFAAKDVEVFGSDVPMERPGQPVEVAPSYLYLASDDSTYVTGQTIH VNGGTIVNG*" /label="yhxC CDS" gene 1039923..1040780 /gene="yhxC" /locus_tag="BSU_10400" /old_locus_tag="BSU10400" /label="yhxC gene" downshifts 1040762 /Source="Nicolas_upshifts" /id="D566" /incds=0 /nref=10 /ntot=36 /MaxReadThrough="2.65833" /MaxDrop="4.80135" /score="-8.69335909" /energy="-4.5" /TU="NA" /idTUdmin="U839" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1040808..1041041) /gene="yhzC" /locus_tag="BSU_10410" /old_locus_tag="BSU10410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388922.1" /db_xref="EnsemblGenomes-Gn:BSU10410" /db_xref="EnsemblGenomes-Tr:CAB12881" /db_xref="InterPro:IPR014957" /db_xref="SubtiList:BG13087" /db_xref="UniProtKB/Swiss-Prot:O31594" /translation="MKEKKSYTELMKSRNTQKTKEFDVTMTDIYIQMVLDESLYNRRL AMLTDQINKALDEKDKDAFLTLSKEYAALKQSE*" /label="yhzC CDS" gene complement(1040808..1041041) /gene="yhzC" /locus_tag="BSU_10410" /old_locus_tag="BSU10410" /label="yhzC gene" downshifts complement(1040841) /Source="Nicolas_upshifts" /id="D567" /incds=0 /nref=191 /ntot=247 /MaxReadThrough="3.34616" /MaxDrop="7.00218" /score="21.4902337" /energy="-12.3" /TU="U841" /idTUdmin="U844" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1041058..1041077) /Source="Nicolas_upshift_promotors" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1041061..1041062 /Source="Nicolas_upshift_promotors" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1041061 /Source="Nicolas_upshifts" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1041065..1041080 /Source="Nicolas_upshift_promotors" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1041080) /Source="Nicolas_upshifts" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1041082..1041937) /Source="Nicolas_S_feature" /locus_tag="new_1116857_1117712_c" /HighExp="Salt, Etha, C30, Heat, S8, LPhT, Gly, C90, S7, UNK1" /AntisenseName="comK" /AntisenseCor="-5.68778941053006E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S365" promotor_-35 complement(1041092..1041099) /Source="Nicolas_upshift_promotors" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1041264..1041271 /Source="Nicolas_upshift_promotors" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="promotor_-35" promotor_-10 1041283..1041302 /Source="Nicolas_upshift_promotors" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="promotor_-10" upshifts 1041289 /Source="Nicolas_upshifts" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="upshifts" CDS 1041334..1041912 /gene="comK" /locus_tag="BSU_10420" /old_locus_tag="BSU10420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15743949, 15819619, 16554821, 16907804, 17468244, 26091431, 27501195, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15819619, 16554821, 16907804, 17468244, 26091431, 27501195, 27920766; Product type r: regulator" /codon_start=1 /transl_table=11 /product="competence transcription factor (CTF)" /protein_id="NP_388923.1" /db_xref="EnsemblGenomes-Gn:BSU10420" /db_xref="EnsemblGenomes-Tr:CAB12882" /db_xref="GOA:P40396" /db_xref="InterPro:IPR010461" /db_xref="SubtiList:BG11059" /db_xref="UniProtKB/Swiss-Prot:P40396" /translation="MSQKTDAPLESYEVNGATIAVLPEEIDGKICSKIIEKDCVFYVN MKPLQIVDRSCRFFGSSYAGRKAGTYEVTKISHKPPIMVDPSNQIFLFPTLSSTRPQC GWISHVHVKEFKATEFDDTEVTFSNGKTMELPISYNSFENQVYRTAWLRTKFQDRIDH RVPKRQEFMLYPKEERTKMIYDFILRELGERY*" /label="comK CDS" gene 1041334..1041912 /gene="comK" /locus_tag="BSU_10420" /old_locus_tag="BSU10420" /label="comK gene" S_feature 1041913..1042058 /Source="Nicolas_S_feature" /locus_tag="new_1117688_1117833" /HighExp="GM 150, C30, T-4.40H, T-3.40H, GM 120, M9-tran, T-2.40H, C90, G/S, T-1.10H" /AntisenseName="yhxD" /AntisenseCor="-0.229484184862048" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S366" CDS complement(1041959..1042858) /gene="yhxD" /locus_tag="BSU_10430" /old_locus_tag="BSU10430" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388924.1" /db_xref="EnsemblGenomes-Gn:BSU10430" /db_xref="EnsemblGenomes-Tr:CAB12883" /db_xref="GOA:P40398" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11060" /db_xref="UniProtKB/Swiss-Prot:P40398" /translation="MSDSNLTNPIKAFFHDEFPEQYQEPPGLQKNMKPVPDCGEKSYK GSGKLTGRKALVTGGDSGIGRAAAIAYAREGADVAINYLPEEQPDAEEVKELIEAEGR KAVLIPGDLSDESFCQDLVKQSHHELGGLDVLALVAGKQQAVENIEDLPTEQIYKTFE VNVFSLYWVVKAALPYLPEGASIITTTSVEGYNPSPMLLDYAATKNAIIGFTVGLGKQ LASKGIRVNSVAPGPIWTPLQISGGQPTENIPKFGQGTPPAPLNRAGQPVELADVYVF LASENSSYVTSQVYGITGGIPTA*" /label="yhxD CDS" gene complement(1041959..1042858) /gene="yhxD" /locus_tag="BSU_10430" /old_locus_tag="BSU10430" /label="yhxD gene" downshifts complement(1041982) /Source="Nicolas_upshifts" /id="D568" /incds=0 /nref=7 /ntot=53 /MaxReadThrough="4.95535" /MaxDrop="4.1467" /score="-2.68458203" /energy="-14.6" /TU="U844" /idTUdmin="U844" /TUdmin="-1144" /isTUend="FALSE" /label="downshifts" promotor_-35 1042045..1042048 /Source="Nicolas_upshift_promotors" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1042060 /Source="Nicolas_upshifts" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1042066..1042070 /Source="Nicolas_upshift_promotors" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1042104 /Source="Nicolas_upshifts" /id="D569" /incds=1 /nref=1 /ntot=5 /MaxReadThrough="5.45904" /MaxDrop="5.6543" /score="-8.69335909" /energy="-4.5" /TU="U842" /idTUdmin="U843" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1042149..1043015 /Source="Nicolas_S_feature" /locus_tag="new_1117924_1118790" /HighExp="GM 150, C30, T-4.40H, C90, T-3.40H, T-2.40H, G/S, T-5.40H, M9-tran, nit" /AntisenseName="yhxD" /AntisenseCor="-0.32746434250834699" /AntisenseRegPval="-7.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S367" promotor_-10 complement(1042885..1042903) /Source="Nicolas_upshift_promotors" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1042902) /Source="Nicolas_upshifts" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1042918..1042924) /Source="Nicolas_upshift_promotors" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1042992..1042999 /Source="Nicolas_upshift_promotors" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1043014..1043033 /Source="Nicolas_upshift_promotors" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1043017 /Source="Nicolas_upshifts" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="upshifts" CDS 1043075..1043344 /gene="yhjA" /locus_tag="BSU_10440" /old_locus_tag="BSU10440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388925.1" /db_xref="EnsemblGenomes-Gn:BSU10440" /db_xref="EnsemblGenomes-Tr:CAB12884" /db_xref="InterPro:IPR008613" /db_xref="SubtiList:BG13068" /db_xref="UniProtKB/Swiss-Prot:O07555" /translation="MKKAAAVLLSLGLVFGFSYGAGHVAEAKTKVKVYKNCKELNKVY KGGVARTSKVKNKGGKTKYKPYVSKALYDANKNKDRDKDLIACER*" /label="yhjA CDS" gene 1043075..1043344 /gene="yhjA" /locus_tag="BSU_10440" /old_locus_tag="BSU10440" /label="yhjA gene" downshifts 1043336 /Source="Nicolas_upshifts" /id="D570" /incds=0 /nref=230 /ntot=267 /MaxReadThrough="2.67325" /MaxDrop="7.59695" /score="27.4895724" /energy="-11.2" /TU="NA" /idTUdmin="U845" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1043384) /Source="Nicolas_upshifts" /id="D571" /incds=0 /nref=11 /ntot=113 /MaxReadThrough="2.40747" /MaxDrop="4.60953" /score="20.2036192" /energy="-11.2" /TU="NA" /idTUdmin="U846" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(1043387..1044856) /gene="yhjB" /locus_tag="BSU_10450" /old_locus_tag="BSU10450" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16267290, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/metabolite cotransporter" /protein_id="NP_388926.1" /db_xref="EnsemblGenomes-Gn:BSU10450" /db_xref="EnsemblGenomes-Tr:CAB12885" /db_xref="GOA:O07556" /db_xref="InterPro:IPR001734" /db_xref="SubtiList:BG13069" /db_xref="UniProtKB/Swiss-Prot:O07556" /translation="MNAALIIIFGVLLLSIFLGIRAQKGKDMNLEQWTVGGRGFGTVF VFLLMAGEIYTTFTFLGGSGWAYGKGGPAFYIIAYGCLAYILSYWLLPAVWTYAKQHK LMSQSDFFTKKYNSPLLGILVSLVGIAALIPYLVLQLKGLGLIVSETSYGKITPTAAI WIGAVSITVYVMVSGIHGSAWISVVKDIMILVVVLFLGVYLPIHYYGGFQDMFQQIET AKPGFLTLPESGQSVAWFSSTVLLTALGFYMWPHTFSASYSAENPKVFRKNAIIMPLY QLVLLFVLFVGFAAILQVPDLNGADGDLSLLRLSLQAFDPWFVGIIGAAGLLTALVPG SMILMSASTLFAKNVYKVIAPRTTEQQVSALAKFLVPVIALISVYFTFKGGNTIVTLL LMGYSLVTQLFPALLFSLLKHNMVTKQGAFAGIIAGVGAVTYITMTETTIGTLFPALP QAAKDLNVGIVALLLNITVMMAVSLMTRKAKSAAADQAA*" /label="yhjB CDS" gene complement(1043387..1044856) /gene="yhjB" /locus_tag="BSU_10450" /old_locus_tag="BSU10450" /label="yhjB gene" CDS complement(1044853..1045053) /gene="yhjC" /locus_tag="BSU_10460" /old_locus_tag="BSU10460" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388927.1" /db_xref="EnsemblGenomes-Gn:BSU10460" /db_xref="EnsemblGenomes-Tr:CAB12886" /db_xref="GOA:O07557" /db_xref="InterPro:IPR021741" /db_xref="SubtiList:BG13070" /db_xref="UniProtKB/Swiss-Prot:O07557" /translation="MKLIHVLAALPFIGILLGIPFANKVTPYVFGMPFILAYIVMWAL LTSALMAIVYVLDKENKKEEAE*" /label="yhjC CDS" gene complement(1044853..1045053) /gene="yhjC" /locus_tag="BSU_10460" /old_locus_tag="BSU10460" /label="yhjC gene" S_feature complement(1045054..1045172) /Source="Nicolas_S_feature" /locus_tag="new_1120829_1120947_c" /HighExp="S1, Etha, HiOs, MG 120, LoTm, T-5.40H, S2, GM-0.1, GM-0.2, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S368" promotor_-10 complement(1045155..1045174) /Source="Nicolas_upshift_promotors" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1045172) /Source="Nicolas_upshifts" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1045187..1045194) /Source="Nicolas_upshift_promotors" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1045260) /Source="Nicolas_upshifts" /id="D572" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="3.99656" /MaxDrop="2.67326" /score="20.2036192" /energy="-11.2" /TU="U848" /idTUdmin="U848" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS complement(1045261..1045623) /gene="yhjD" /locus_tag="BSU_10470" /old_locus_tag="BSU10470" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16267290" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388928.1" /db_xref="EnsemblGenomes-Gn:BSU10470" /db_xref="EnsemblGenomes-Tr:CAB12887" /db_xref="GOA:O07558" /db_xref="SubtiList:BG13071" /db_xref="UniProtKB/Swiss-Prot:O07558" /translation="MPNLQEEIYDLIERALFLPMAITIFNRDLAGIEESTLKLKHPYK QLISESLKIAQKDLMEVRKELRKRKIAIRETERDEAFTLYTFVIDGYEENHRYFNPRI REQVSELLTYYLFAPDRL*" /label="yhjD CDS" gene complement(1045261..1045623) /gene="yhjD" /locus_tag="BSU_10470" /old_locus_tag="BSU10470" /label="yhjD gene" promotor_-35 1045461..1045466 /Source="Nicolas_upshift_promotors" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1045482..1045500 /Source="Nicolas_upshift_promotors" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1045483 /Source="Nicolas_upshifts" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="upshifts" S_feature 1045492..1045731 /Source="Nicolas_S_feature" /locus_tag="new_1121267_1121506" /HighExp="S6, S4, S8, S5, LoTm, B36, S3, S7, BT, B60" /AntisenseName="yhjD" /AntisenseCor="0.24202608585419999" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.963" /TUlongSig="NA" /TUlongPSig="NA" /label="S369" promotor_-10 complement(1045653..1045672) /Source="Nicolas_upshift_promotors" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1045671) /Source="Nicolas_upshifts" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1045687..1045694) /Source="Nicolas_upshift_promotors" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1045713..1045720 /Source="Nicolas_upshift_promotors" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1045733 /Source="Nicolas_upshifts" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1045734..1045753 /Source="Nicolas_upshift_promotors" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1045775..1046398 /gene="yhjE" /locus_tag="BSU_10480" /old_locus_tag="BSU10480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388929.1" /db_xref="EnsemblGenomes-Gn:BSU10480" /db_xref="EnsemblGenomes-Tr:CAB12888" /db_xref="GOA:O07559" /db_xref="InterPro:IPR015414" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13072" /db_xref="UniProtKB/Swiss-Prot:O07559" /translation="MLEHFLSYLTQEHLTELFQSYRAFGPLIAVLLPLIEAFLPFLPL IVFVVANTNSFGLWEGFILSWAGSTAGSILVFLIVRQYGQRKLLGFIRSHPSVRKLML WVERHGFGPMFLLLCFPFTPSAAVNVVAGLSRIGTRPFILAAASGKLVMIFMISFIGY DLHALITQPIRTVIAVLVITVLWYVGKKVERYLHVRASQREHDGGRQ*" /label="yhjE CDS" gene 1045775..1046398 /gene="yhjE" /locus_tag="BSU_10480" /old_locus_tag="BSU10480" /label="yhjE gene" CDS 1046400..1046906 /gene="sipV" /locus_tag="BSU_10490" /old_locus_tag="BSU10490" /EC_number="3.4.21.89" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9325333, 9694797, 11309398, 12897006, 14568161, 27159567" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 9694797, 11309398, 12897006, 14568161, 27159567; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_388930.1" /db_xref="EnsemblGenomes-Gn:BSU10490" /db_xref="EnsemblGenomes-Tr:CAB12889" /db_xref="GOA:O07560" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG12674" /db_xref="UniProtKB/Swiss-Prot:O07560" /translation="MKKRFWFLAGVVSVVLAIQVKNAVFIDYKVEGVSMNPTFQEGNE LLVNKFSHRFKTIHRFDIVLFKGPDHKVLIKRVIGLPGETIKYKDDQLYVNGKQVAEP FLKHLKSVSAGSHVTGDFSLKDVTGTSKVPKGKYFVVGDNRIYSFDSRHFGPIREKNI VGVISDAE*" /label="sipV CDS" gene 1046400..1046906 /gene="sipV" /locus_tag="BSU_10490" /old_locus_tag="BSU10490" /label="sipV gene" downshifts 1046899 /Source="Nicolas_upshifts" /id="D573" /incds=0 /nref=131 /ntot=250 /MaxReadThrough="0.63331" /MaxDrop="4.58282" /score="-7.37718733" /energy="-7.1" /TU="NA" /idTUdmin="U847" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1046957..1046964 /Source="Nicolas_upshift_promotors" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1046978..1046997 /Source="Nicolas_upshift_promotors" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1046987..1047086 /Source="Nicolas_S_feature" /locus_tag="new_1122762_1122861" /HighExp="LBGstat, LBGexp, Lbtran, C90, dia0, Lbexp, HPh, dia5, aero, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S370" upshifts 1046987 /Source="Nicolas_upshifts" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="upshifts" CDS 1047087..1048586 /gene="yhjG" /locus_tag="BSU_10500" /old_locus_tag="BSU10500" /EC_number="1.14.13.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7678243, 15121720; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aromatic compound monooxygenase/hydroxylase" /protein_id="NP_388931.1" /db_xref="EnsemblGenomes-Gn:BSU10500" /db_xref="EnsemblGenomes-Tr:CAB12890" /db_xref="GOA:O07561" /db_xref="InterPro:IPR002938" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13073" /db_xref="UniProtKB/Swiss-Prot:O07561" /translation="MMMKYEAVIIGGGPVGFMLASELAIAGVGTCVIERLEKPVPHSK ALTLHPRTLELLEMRGILERFVSKGSKIPTGHFSMLDTRLDFSGLDTSCPYTLLLPQS KTEKLLEDHARSLGTEVFRGAEALAVTQNGEAVQTIFKDRDGSVRTITSKFAVGADGA GSTVRKQAKIEFPGTDSTVTAALGDVVLLSPPPSGVLSLCTKEGGVMIVPLSPDRYRV VVISPYRTQTPKDVPVTEEELKADLLRICGTDFGLTDPSWMSRFGNAARQAKRYRDGR IFLAGDAAHIHFPAGGQGLNVGLQDAMNLGWKLAAAIKGSAPSWLLDSYHDERHPAAE GLLRNTEAQTKLIDFTQAGLHLRSMMSELLAFPDVNRYVAGQISALDVRYEADRTMPP NRLNGARLPDMKLILSDGNSERLYSFLQNGTFVLLSLRQEADDHIEVKGLRTVTASLA EPNEKLRNVHTILIRPDGHVAWAVDASAPDCSEVIQKGISRWFSVTSRV*" /label="yhjG CDS" gene 1047087..1048586 /gene="yhjG" /locus_tag="BSU_10500" /old_locus_tag="BSU10500" /label="yhjG gene" promotor_-35 1048594..1048601 /Source="Nicolas_upshift_promotors" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1048613 /Source="Nicolas_upshifts" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1048615..1048634 /Source="Nicolas_upshift_promotors" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1048663..1049190 /gene="yhjH" /locus_tag="BSU_10510" /old_locus_tag="BSU10510" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388932.1" /db_xref="EnsemblGenomes-Gn:BSU10510" /db_xref="EnsemblGenomes-Tr:CAB12891" /db_xref="GOA:Q796S4" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13074" /db_xref="UniProtKB/Swiss-Prot:Q796S4" /translation="MNTDHTKRNLFELYAELIHQQEKWEGLIKAFLSDELRKLDVEHG SKSQLTMTEIHVLSCVGDNEPINVTSIAEKMNTTKATVSRISTKLLGAGFLHRTQLSD NKKEVYFRLTPAGKKLHSLHKYYHQKAEQRFLSFFDRYTEEEILFAERLFRDLVTKWY PSSEEIEGGLPSIFK*" /label="yhjH CDS" gene 1048663..1049190 /gene="yhjH" /locus_tag="BSU_10510" /old_locus_tag="BSU10510" /label="yhjH gene" downshifts 1049152 /Source="Nicolas_upshifts" /id="D574" /incds=0 /nref=8 /ntot=128 /MaxReadThrough="1.1509" /MaxDrop="3.41655" /score="11.3050978" /energy="-9.9" /TU="NA" /idTUdmin="U851" /TUdmin=8 /isTUend="TRUE" /label="downshifts" S_feature complement(1049204..1049347) /Source="Nicolas_S_feature" /locus_tag="new_1124979_1125122_c" /HighExp="B36, B60, T0.30H, LBGstat, T1.30H, T1.0H, LPhT, LBGtran, Diami, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.979" /TUlongSig="NA" /TUlongPSig="NA" /label="S371" downshifts complement(1049242) /Source="Nicolas_upshifts" /id="D575" /incds=0 /nref=4 /ntot=72 /MaxReadThrough="1.20458" /MaxDrop="5.06167" /score="27.254423" /energy="-9.9" /TU="NA" /idTUdmin="U855" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1049348..1050553) /gene="glcP" /locus_tag="BSU_10520" /old_locus_tag="BSU10520" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9457850, 15849754, 16850406, 17056753, 19087206" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9457850, 15849754, 16850406, 17056753, 19087206; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glucose/mannose:H+ symporter (recent HGT island)" /protein_id="NP_388933.1" /db_xref="EnsemblGenomes-Gn:BSU10520" /db_xref="EnsemblGenomes-Tr:CAB12892" /db_xref="GOA:O07563" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13075" /db_xref="UniProtKB/Swiss-Prot:O07563" /translation="MLRGTYLFGYAFFFTVGIIHISTGSLTPFLLEAFNKTTDDISVI IFFQFTGFLSGVLIAPLMIKKYSHFRTLTLALTIMLVALSIFFLTKDWYYIIVMAFLL GYGAGTLETTVGSFVIANFESNAEKMSKLEVLFGLGALSFPLLINSFIDINNWFLPYY CIFTFLFVLFVGWLIFLSKNREYAKNANQQVTFPDGGAFQYFIGDRKKSKQLGFFVFF AFLYAGIETNFANFLPSIMINQDNEQISLISVSFFWVGIIIGRILIGFVSRRLDFSKY LLFSCSCLIVLLIAFSYISNPILQLSGTFLIGLSIAGIFPIALTLASIIIQKYVDEVT SLFIASASFGGAIISFLIGWSLNQDTILLTMGIFTTMAVILVGISVKIRRTKTEDPIS LENKASKTQ*" /label="glcP CDS" gene complement(1049348..1050553) /gene="glcP" /locus_tag="BSU_10520" /old_locus_tag="BSU10520" /label="glcP gene" promotor_-35 1050043..1050048 /Source="Nicolas_upshift_promotors" /id="U852" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1194 /SigmaFactorBS="tctcggttcttagacaagaaaattaaccaccctaCGAATAgg acgaataaaaaggtGAATATACAGTAATATGGTaaaaaccagttattgatatctatga a" /listShort="S372" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1050065..1050083 /Source="Nicolas_upshift_promotors" /id="U852" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1194 /SigmaFactorBS="tctcggttcttagacaagaaaattaaccaccctaCGAATAgg acgaataaaaaggtGAATATACAGTAATATGGTaaaaaccagttattgatatctatga a" /listShort="S372" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1050068..1050594 /Source="Nicolas_S_feature" /locus_tag="new_1125843_1126369" /HighExp="S4, S5, S6, S8, S7, S3, T5.0H, M9-stat, LBGstat, T4.0H" /AntisenseName="glcP" /AntisenseCor="-0.155079396671681" /AntisenseRegPval="-2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S372" upshifts 1050069 /Source="Nicolas_upshifts" /id="U852" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1194 /SigmaFactorBS="tctcggttcttagacaagaaaattaaccaccctaCGAATAgg acgaataaaaaggtGAATATACAGTAATATGGTaaaaaccagttattgatatctatga a" /listShort="S372" /GFF_Attribute="listLong" /label="upshifts" downshifts 1050552 /Source="Nicolas_upshifts" /id="D576" /incds=0 /nref=6 /ntot=59 /MaxReadThrough="2.40974" /MaxDrop="3.26024" /score="9.68585629" /energy="-9.4" /TU="NA" /idTUdmin="U852" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1050625..1051677) /gene="ntdC" /locus_tag="BSU_10530" /old_locus_tag="BSU10530" /EC_number="1.1.1.-" /function="16.8: Protect" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14612444, 17056753, 23586652, 28353336" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612444, 17056753, 23586652, 28353336; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biosynthesis of neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha,beta-trehalose), glucose-6-P 3-dehydrogenase; kanosamine biosynthesis (recent HGT island)" /protein_id="NP_388934.2" /db_xref="EnsemblGenomes-Gn:BSU10530" /db_xref="EnsemblGenomes-Tr:CAB12893" /db_xref="GOA:O07564" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13076" /db_xref="UniProtKB/Swiss-Prot:O07564" /translation="MKKIGIIGAGGIARAHATALSTIKNAELVGVYDINQQNAESFVK TFGGKSFENVDELIDASEGLIVASPNFCHKEHALQALGKHKHVLCEKPMAISLEEASI MKDTAERLSVRASMGFNYRYLSYVNILKSLIINNELGNILSIKVHFKKNSALRRKKFT WRDDANSKKTSGSLGDLGIHLIDMVWYLFESDFITESVRAKMNTNVKTKEDKQVLVDD YAEIYGQLKNKVFVNIITSKCSVPEDCGFSIEVVGHKKEFKYHTGNPHVYKLIDGLNV VDCPVPQSLLNDPPNEFYGWADSFRSELINWIASTQNDWVEIPSFSDGFRSQEVLEMF FEKDSNSQPMSVSAVN*" /label="ntdC CDS" gene complement(1050625..1051677) /gene="ntdC" /locus_tag="BSU_10530" /old_locus_tag="BSU10530" /label="ntdC gene" CDS complement(1051691..1052539) /gene="ntdB" /locus_tag="BSU_10540" /old_locus_tag="BSU10540" /EC_number="3.-.-.-" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14612444, 17056753, 23586652" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612444, 17056753, 23586652; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biosynthesis of neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha, beta-trehalose);kanosamine-6-phosphate phosphatase (recent HGT island)" /protein_id="NP_388935.2" /db_xref="EnsemblGenomes-Gn:BSU10540" /db_xref="EnsemblGenomes-Tr:CAB12894" /db_xref="GOA:O07565" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR006380" /db_xref="InterPro:IPR036412" /db_xref="PDB:3GYG" /db_xref="SubtiList:BG13077" /db_xref="UniProtKB/Swiss-Prot:O07565" /translation="MLLSKKSEYKTLSTVEHPQYIVFCDFDETYFPHTIDEQKQQDIY ELEDYLEQKSKDGELIIGWVTGSSIESILDKMGRGKFRYFPHFIASDLGTEITYFSEH NFGQQDNKWNSRINEGFSKEKVEKLVKQLHENHNILLNPQTQLGKSRYKHNFYYQEQD EINDKKNLLAIEKICEEYGVSVNINRCNPLAGDPEDSYDVDFIPIGTGKNEIVTFMLE KYNLNTERAIAFGDSGNDVRMLQTVGNGYLLKNATQEAKNLHNLITDSEYSKGITNTL KKLIGS*" /label="ntdB CDS" gene complement(1051691..1052539) /gene="ntdB" /locus_tag="BSU_10540" /old_locus_tag="BSU10540" /label="ntdB gene" CDS complement(1052511..1053836) /gene="ntdA" /locus_tag="BSU_10550" /old_locus_tag="BSU10550" /EC_number="2.6.1.-" /function="16.5: Explore" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14612444, 17056753, 19087206, 23586652, 24097983, 24509311, 28353336" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612444, 17056753, 19087206, 23586652, 24097983, 24509311, 28353336; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biosynthesis of neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha, beta-trehalose);3-oxo-glucose-6-phosphate:glutamate aminotransferase; kanosamine aminotransferase (recent HGT island)" /protein_id="NP_388936.1" /db_xref="EnsemblGenomes-Gn:BSU10550" /db_xref="EnsemblGenomes-Tr:CAB12895" /db_xref="GOA:O07566" /db_xref="InterPro:IPR000653" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="PDB:4K2B" /db_xref="PDB:4K2I" /db_xref="PDB:4K2M" /db_xref="SubtiList:BG13078" /db_xref="UniProtKB/Swiss-Prot:O07566" /translation="MQKQVKISGKSKENMSLLKHLKGDVQGKELVIEDSIVNERWKQV LKEKIDIEHDLFNYQKNREISKVPFLPVDRLITNDEVEDILNTLTEVLPTGKFTSGPY LEQFEKVLSTYLHKRYVIATSSGTDAIMIGLLALGLNPGDEVIMPANSFSATENAVLA SGGVPIYVDINPQTFCIDPDKIEEAITPYTKFILPVHLYGKHSDMQHIRQIANRYKLK VIEDACQGIGLTDLGKYADITTLSFNPYKNFGVCGKAGAIATDNEELAKKCIQFSYHG FEVNVKNKKVINFGFNSKMDNLQAAIGLERMKYLSLNNFKRLFLADRYITQLAELQNK GYIELPELSEDHVWHLFPIKVRTEDRADIMTKLNEDFGVQTDVYYPILSHMQKTPLVQ DKYAGLQLVHTEKAHSQVLHLPLYPSFTLEEQDRVMEGLFHVIKQEIGV*" /label="ntdA CDS" gene complement(1052511..1053836) /gene="ntdA" /locus_tag="BSU_10550" /old_locus_tag="BSU10550" /label="ntdA gene" promotor_-35 1052680..1052685 /Source="Nicolas_upshift_promotors" /id="U853" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1031 /SigmaFactorBS="cctgcatacttgtcctgtactaaaggagtttttTGCATAtga gaaagtattggaTAATATACATCTGTTTGAAcaccaaaatcttcatttaatttagtca t" /listShort="S373, S374, yhjM" /listLong="S375" /label="promotor_-35" promotor_-10 1052701..1052719 /Source="Nicolas_upshift_promotors" /id="U853" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1031 /SigmaFactorBS="cctgcatacttgtcctgtactaaaggagtttttTGCATAtga gaaagtattggaTAATATACATCTGTTTGAAcaccaaaatcttcatttaatttagtca t" /listShort="S373, S374, yhjM" /listLong="S375" /label="promotor_-10" S_feature 1052707..1053495 /Source="Nicolas_S_feature" /locus_tag="new_1128482_1129270" /HighExp="S4, S3, S5, S6, S7, T5.0H, M9-stat, S8, Pyr, G/S" /AntisenseName="ntdA" /AntisenseCor="-0.29559566742128002" /AntisenseRegPval="-6.1" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S373" upshifts 1052707 /Source="Nicolas_upshifts" /id="U853" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1031 /SigmaFactorBS="cctgcatacttgtcctgtactaaaggagtttttTGCATAtga gaaagtattggaTAATATACATCTGTTTGAAcaccaaaatcttcatttaatttagtca t" /listShort="S373, S374, yhjM" /listLong="S375" /label="upshifts" promotor_-35 1053471..1053478 /Source="Nicolas_upshift_promotors" /id="U854" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.776223776223776" /psig="0.998001998001998" /xcortree=2928 /SigmaFactorBS="ataaacctatcataatagcatcggttccactgctGGTTGCAA ttacataccttttaTGTAAATATGTAGATAAAACtttttcgaattgctctaaataggg a" /listShort="S374, yhjM, S375" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1053493..1053512 /Source="Nicolas_upshift_promotors" /id="U854" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.776223776223776" /psig="0.998001998001998" /xcortree=2928 /SigmaFactorBS="ataaacctatcataatagcatcggttccactgctGGTTGCAA ttacataccttttaTGTAAATATGTAGATAAAACtttttcgaattgctctaaataggg a" /listShort="S374, yhjM, S375" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1053497..1053939 /Source="Nicolas_S_feature" /locus_tag="new_1129272_1129714" /HighExp="T4.0H, T3.0H, T2.30H, HiOs, T3.30H, T2.0H, T5.0H, T1.30H, LoTm, T-1.10H" /AntisenseName="ntdA" /AntisenseCor="-0.101471720232752" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.998, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S374" upshifts 1053497 /Source="Nicolas_upshifts" /id="U854" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.776223776223776" /psig="0.998001998001998" /xcortree=2928 /SigmaFactorBS="ataaacctatcataatagcatcggttccactgctGGTTGCAA ttacataccttttaTGTAAATATGTAGATAAAACtttttcgaattgctctaaataggg a" /listShort="S374, yhjM, S375" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1053871..1053890) /Source="Nicolas_upshift_promotors" /id="U855" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.849150849150849" /psig="0.97902097902098" /xcortree=1578 /SigmaFactorBS="gcatattttcccttccttaaaaaagttgttgaCATGTTACcg atttcagaaacTAGGATAAATTTGTAATAAAtttttagattataaaatcattggaggt a" /listShort="ntdA, ntdB, ntdC, glcP, S371" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1053883) /Source="Nicolas_upshifts" /id="U855" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.849150849150849" /psig="0.97902097902098" /xcortree=1578 /SigmaFactorBS="gcatattttcccttccttaaaaaagttgttgaCATGTTACcg atttcagaaacTAGGATAAATTTGTAATAAAtttttagattataaaatcattggaggt a" /listShort="ntdA, ntdB, ntdC, glcP, S371" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1053904..1053911) /Source="Nicolas_upshift_promotors" /id="U855" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.849150849150849" /psig="0.97902097902098" /xcortree=1578 /SigmaFactorBS="gcatattttcccttccttaaaaaagttgttgaCATGTTACcg atttcagaaacTAGGATAAATTTGTAATAAAtttttagattataaaatcattggaggt a" /listShort="ntdA, ntdB, ntdC, glcP, S371" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1053940..1054929 /gene="ntdR" /locus_tag="BSU_10560" /old_locus_tag="BSU10560" /experiment="publication(s) with functional evidences, PMID:14612444, 17056753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612444, 17056753; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the ntd operon (NtdR-NTD) (recent HGT island)" /protein_id="NP_388937.1" /db_xref="EnsemblGenomes-Gn:BSU10560" /db_xref="EnsemblGenomes-Tr:CAB12896" /db_xref="GOA:O07567" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13079" /db_xref="UniProtKB/Swiss-Prot:O07567" /translation="MPTIDEIAKLCNVSKTTVSRVLNNHPYVSKEKRDMILKAINELD YTPNYLARNFRRNKTQTIALSVPSIDHPFFAQLIKGVSHEVLFKNYKVIVFQTFYDKQ TELELLELLKHKEVDGIILGTLENEWDQISPFLKYGPILLCNEYHHSADITIIGYDEF EAAYMGVVHLIERGHKKIGFCFDTPYSEAQCQRKEGYLKALQDYNLHHRSEWIFGEMF NIEDGFRVFHKIKDLKDRPSAIFTGNDQVAAGIIKQAMKNGFKVPEDLAVIGFDNQLI CQVVTPTITTIDIPVIELGQQAVLKIIESISGNASLNRRIIKLPTKLIIREST*" /label="ntdR CDS" gene 1053940..1054929 /gene="ntdR" /locus_tag="BSU_10560" /old_locus_tag="BSU10560" /label="ntdR gene" S_feature 1054930..1055307 /Source="Nicolas_S_feature" /locus_tag="new_1130705_1131082" /HighExp="T4.0H, T5.0H, T3.30H, T2.0H, HiOs, T2.30H, T3.0H, LoTm, T1.30H, Pyr" /AntisenseName="yhjN" /AntisenseCor="-5.0383887616073E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig="0.997" /label="S375" S_feature complement(1054984..1055142) /Source="Nicolas_S_feature" /locus_tag="new_1130759_1130917_c" /HighExp="B60, Sw, Cold, B36, BI, GM 15, GM 10, C30, GM 25, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S376" downshifts complement(1055027) /Source="Nicolas_upshifts" /id="D577" /incds=0 /nref=25 /ntot=169 /MaxReadThrough="3.07371" /MaxDrop="4.24831" /score="-1.9470655" /energy="-7.1" /TU="U856" /idTUdmin="U856" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(1055143..1056297) /gene="yhjN" /locus_tag="BSU_10570" /old_locus_tag="BSU10570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein (recentHGT island)" /protein_id="NP_388938.1" /db_xref="EnsemblGenomes-Gn:BSU10570" /db_xref="EnsemblGenomes-Tr:CAB12897" /db_xref="GOA:O07568" /db_xref="InterPro:IPR007820" /db_xref="InterPro:IPR017516" /db_xref="SubtiList:BG13080" /db_xref="UniProtKB/Swiss-Prot:O07568" /translation="MKKDENLLKDLWFIAISAAGGFILSLTGISIGWMIGTLIVACCL AMIRPAWLMMAPDQKGINRRWLALGQMILGIELGQKLNLSVLSVLKDHWFSVGVMLIL SILLAMLSGYVLWRFSKTDMMTSFVGTAPGGLSAMPSIAQEVGANTAIVSLVQMMRVL LVVLSIPFLVILIYTKQDRTASAAAETISSATTDFRLAPVLWTVILILAAWGACKAAK FLKFPAPWLLGSMLGVAIVHVGGAAVTGHDMTAWWLSQANHVSQVFLGATIGSKMYKS MFAGVTRIIIVGFVSSVGLIAAMFLSAVIVSELTGISLITSVLAFAPGGIAEMATTSV TLHADSTFVVAVQVIRVILVIALLPPFYRLLHHLHGEKKDKKSSISGSSA*" /label="yhjN CDS" gene complement(1055143..1056297) /gene="yhjN" /locus_tag="BSU_10570" /old_locus_tag="BSU10570" /label="yhjN gene" S_feature complement(1056298..1056369) /Source="Nicolas_S_feature" /locus_tag="new_1132073_1132144_c" /HighExp="Cold, GM 15, GM 10, dia15, BC, BI, Salt, B60, Sw, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S377" promotor_-10 complement(1056352..1056371) /Source="Nicolas_upshift_promotors" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1056368) /Source="Nicolas_upshifts" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1056385..1056390) /Source="Nicolas_upshift_promotors" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1056404..1057609) /gene="yhjO" /locus_tag="BSU_10580" /old_locus_tag="BSU10580" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease (recent HGT island)" /protein_id="NP_388939.1" /db_xref="EnsemblGenomes-Gn:BSU10580" /db_xref="EnsemblGenomes-Tr:CAB12898" /db_xref="GOA:O07569" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13081" /db_xref="UniProtKB/Swiss-Prot:O07569" /translation="MLTSFHSIKSRYTAPVRLRFFGELLTSLTGAMMGPFMVLYLHEQ LNGSIMMPMLIISLQPFADIFLTLAAGRVTDRLGRRTAILTALLLQSAAMTGFVFAEH AYVFAILYVMNGIGRSLYIPASRAQIAESTPESRRSEVFAVINAIYSTGLTAGPLVGM LLYNHNPVWIFALDAAALFIYFLIAALKLPETKPLHPAVTPKMSASFTIYRPVLLLLL LSLPISMLYAQTETTYRLFSKNMFSDYLSMLTIYSAAKALFSCVLQVPLVKGTEKLSM KTILFITYICYSLAAAGFACSTSLTMLLVTAAVMTVGESIGLTHIQTFISKLAPPHLL GRFYAVYGLHWDISRSIGPLAGGLILTSFGGEVIFYALAVCLLTAGLSLTYTIEKLEH KVIRKVNRL*" /label="yhjO CDS" gene complement(1056404..1057609) /gene="yhjO" /locus_tag="BSU_10580" /old_locus_tag="BSU10580" /label="yhjO gene" misc_feature 1057630..1057649 /Source="Nicolas_upshift_promotors" /id="U857" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.699300699300699" /psig="0.999000999001" /xcortree=2118 /SigmaFactorBS="tatctcgattttatagagtgaaaactggtcaacatgtgatcg ccgcctttcgctgTTTGATATAGTAGTAGTGTAtagaaggggcggcggcccaaaaagt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1057635 /Source="Nicolas_upshifts" /id="U857" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.699300699300699" /psig="0.999000999001" /xcortree=2118 /SigmaFactorBS="tatctcgattttatagagtgaaaactggtcaacatgtgatcg ccgcctttcgctgTTTGATATAGTAGTAGTGTAtagaaggggcggcggcccaaaaagt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1057723..1059450 /gene="yhjP" /locus_tag="BSU_10590" /old_locus_tag="BSU10590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcription factor" /protein_id="NP_388940.1" /db_xref="EnsemblGenomes-Gn:BSU10590" /db_xref="EnsemblGenomes-Tr:CAB12899" /db_xref="GOA:O07570" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR025370" /db_xref="InterPro:IPR030678" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13082" /db_xref="UniProtKB/Swiss-Prot:O07570" /translation="MKLIEHYVALVKTGCAEYGQMNEMTLTEIADCLFCTERNAKLIL HKLENSNWIIRESGAGRGRKSKIAFLRRPEELLLQTAKEYTMSGKLKKAKELLQQYQS AFPGLQNEYNMWLSEVFGFVTETGENGAKDVLRLFITPESVSSLDPCQIFLRSEGHFV KQIFDTLFTFDSDMQEPKPHLVHGWEEVGKKQWRFFLRKGVLFHNGQPLTSRDVAFTF QRFLELADNPYKWLLHGVKQVLEKGPYCVELILDKPNALLPYALCDERLSILPAEQGG GKNGTGPFQMNQQHSGMLVLEANERYFKGRPYLDRVEFVFSEQAGEMNGFTIQEKQTC PEQQTVFDERHVQYLSLNLKKKGPLQHRSFRKALRLLISSERLVREAGGHRRIPVTSF LHPSPFEWEGVSPSELLKKSGYEGETIVLYTFSETDHREDAEWIQNICAQHGIRLTLQ FCDAADLRRPEIVQMADIIHDSATFYQDSEFGFLHLLLSENSFLYQHLSEKLTQICSG MTERMFSMPDRCSRINILRDIDRQMIQELNAIPLYQNVLQVTSSKNVKGLVLDEEGWI DLYSVWLSK*" /label="yhjP CDS" gene 1057723..1059450 /gene="yhjP" /locus_tag="BSU_10590" /old_locus_tag="BSU10590" /label="yhjP gene" promotor_-35 1059036..1059043 /Source="Nicolas_upshift_promotors" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1059058..1059077 /Source="Nicolas_upshift_promotors" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1059065 /Source="Nicolas_upshifts" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1059480..1059806) /gene="yhjQ" /locus_tag="BSU_10600" /old_locus_tag="BSU10600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12625841; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative metal-chelating cysteine-rich protein of unknown function" /protein_id="NP_388941.1" /db_xref="EnsemblGenomes-Gn:BSU10600" /db_xref="EnsemblGenomes-Tr:CAB12900" /db_xref="InterPro:IPR005560" /db_xref="PDB:5FIG" /db_xref="SubtiList:BG13083" /db_xref="UniProtKB/Swiss-Prot:O07571" /translation="MEQYSEACIEACIDCMKACNHCFTKCLEESVQHHLSGCIRLDRE CADICALAVKAMQTDSPFMKEICALCADICEACGTECGKHDHDHCQACAKACFTCAEQ CRSMAA*" /label="yhjQ CDS" gene complement(1059480..1059806) /gene="yhjQ" /locus_tag="BSU_10600" /old_locus_tag="BSU10600" /label="yhjQ gene" CDS complement(1059924..1060361) /gene="yhjR" /locus_tag="BSU_10610" /old_locus_tag="BSU10610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22078549, 22882546; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative electron carrier protein (putative sporulation gene)" /protein_id="NP_388942.1" /db_xref="EnsemblGenomes-Gn:BSU10610" /db_xref="EnsemblGenomes-Tr:CAB12901" /db_xref="GOA:O07572" /db_xref="InterPro:IPR003251" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG13084" /db_xref="UniProtKB/Swiss-Prot:O07572" /translation="MHYSYYPYPVPYREDPVLIRNLQKAINGEFSAIQCYRKLAELAH SDEVRKQIEEIRRDEIRHLREFSTLYGSITGKHIMPKQTEECPDNFTRGLDAAFKDEQ ETVDFYLRAAEETSNLKAKGVFTRAARDEQNHAVWFLYYLMER*" /label="yhjR CDS" gene complement(1059924..1060361) /gene="yhjR" /locus_tag="BSU_10610" /old_locus_tag="BSU10610" /label="yhjR gene" downshifts complement(1059933) /Source="Nicolas_upshifts" /id="D578" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.72767" /MaxDrop="3.86885" /score="16.2430017" /energy="-11.5" /TU="U859" /idTUdmin="U859" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1060392..1060411) /Source="Nicolas_upshift_promotors" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1060412) /Source="Nicolas_upshifts" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1060424..1060433) /Source="Nicolas_upshift_promotors" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1060481..1060488 /Source="Nicolas_upshift_promotors" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1060502..1060521 /Source="Nicolas_upshift_promotors" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1060514 /Source="Nicolas_upshifts" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="upshifts" CDS 1060545..1064045 /gene="addB" /locus_tag="BSU_10620" /old_locus_tag="BSU10620" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent deoxyribonuclease (subunit B)" /protein_id="NP_388943.2" /db_xref="EnsemblGenomes-Gn:BSU10620" /db_xref="EnsemblGenomes-Tr:CAB12902" /db_xref="GOA:P23477" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR014140" /db_xref="InterPro:IPR027417" /db_xref="PDB:3U44" /db_xref="PDB:3U4Q" /db_xref="PDB:4CEH" /db_xref="PDB:4CEI" /db_xref="PDB:4CEJ" /db_xref="SubtiList:BG10465" /db_xref="UniProtKB/Swiss-Prot:P23477" /translation="MGAEFLVGRSGSGKTKLIINSIQDELRRAPFGKPIIFLVPDQMT FLMEYELAKTPDMGGMIRAQVFSFSRLAWRVLQHTGGMSRPFLTSTGVQMLLRKLIEE HKQEFKVYQKASDKSGFTAQVERMLTEFKRYCLEPEDIRRMAESGTASEYRGERVLSE KLHDLSILYQQMEKSLADQYLHSEDYLTLLAEHIPLAEDIKGAHIYVDGFYQFTPQEF RVLEQLMVHAEHITFSLTADKPSYEREPHELELFRMTGKTYYRLHQKAKELNLDITYK ELSGTERHTKTPELAHLEAQYEARPAIPYAEKQEALTVMQAANRRAELEGIAREIHAL VREKGYRYKDVAILARQPEDYKDMVKEVFADYEIPYFIDGKASMLNHPLIEFIRSSLD VLKGNWRYEAVFRCVKTELLFPLNEPKAKVREQVDQLENYCIAYGIKGDRWTKGDRFQ YRRFVSLDDDFAQTDQEIEMENMLNDTRDWIVPPLFQLQKRMKKAKTVQEKAEALYRY LEETDVPLKLDQERQRAEDDGRIIEAQQHQQAWDAVIQLLEEFVEMMGDDEISLDLFQ QMIEAGAESLTFSLIPPALDQVFVGNMDLSRMYGTSCTFVLGANDGVLPARPDENGVL SDDDREWLKTIGVELSSGGRERLLDEHFLIYMAFSSPSDRLYVSYPIADAEGKTLLPS MIVKRLEELFPHHKERLLTNEPEQVSDEEQLMYVVNKSVAQSFTASQLRLWTREYDIS DVWWSTYNVLMSEQDRLQSKKLFSSLFFRNEVKQLERSVSRQLYGERIQGSVSRMETF NACPFSHFASHGLHLKERQFFKLEAPDIGQLFHSSLKLISDRLREQKLDWRDLTKEQC ELFSYDAVERLAPKLQKEILLSSNRHYYVKEKLQKIVTRVSGILSEHAKASGFVPIGL ELGFGGKGPLPPLTFQLKNGCTMELVGRIDRVDKAESSKGLLLRIVDYKSSDKGLDLA EVYYGLALQMLTYLDLSITHSADWLGMRATPAGVLYFHIHDPMIQSNLPLGLDEIEQE IFKKFKMKGLLLGDQEVVRLMDTTLQEGRSNIINAGLKKDGSLRSDSAAVGEKEFDLL TKHVRRTFQEAGEQITDGRVSIEPYKMKNKTPCTYCAFKSVCQFDESLEENEYRPLKA EKDKTILEWIKKEADGNEHS*" /label="addB CDS" gene 1060545..1064045 /gene="addB" /locus_tag="BSU_10620" /old_locus_tag="BSU10620" /label="addB gene" CDS 1064032..1067730 /gene="addA" /locus_tag="BSU_10630" /old_locus_tag="BSU10630" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent deoxyribonuclease (subunit A)" /protein_id="NP_388944.2" /db_xref="EnsemblGenomes-Gn:BSU10630" /db_xref="EnsemblGenomes-Tr:CAB12903" /db_xref="GOA:P23478" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR011335" /db_xref="InterPro:IPR011604" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR014152" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="PDB:3U44" /db_xref="PDB:3U4Q" /db_xref="PDB:4CEH" /db_xref="PDB:4CEI" /db_xref="PDB:4CEJ" /db_xref="SubtiList:BG10466" /db_xref="UniProtKB/Swiss-Prot:P23478" /translation="MNIPKPADSTWTDDQWNAIVSTGQDILVAAAAGSGKTAVLVERM IRKITAEENPIDVDRLLVVTFTNASAAEMKHRIAEALEKELVQRPGSLHIRRQLSLLN RASISTLHSFCLQVLKKYYYLIDLDPGFRIADQTEGELIGDEVLDELFEDEYAKGEKA FFELVDRYTTDRHDLDLQFLVKQVYEYSRSHPNPEAWLESFVHLYDVSEKSAIEELPF YQYVKEDIAMVLNGAKEKLLRALELTKAPGGPAPRADNFLDDLAQIDELIQHQDDFSE LYKRVPAVSFKRAKAVKGDEFDPALLDEATDLRNGAKKLLEKLKTDYFTRSPEQHLKS LAEMKPVIETLVQLVISYGKRFEAAKQEKSIIDFSDLEHYCLAILTAENDKGEREPSE AARFYQEQFHEVLVDEYQDTNLVQESILQLVTSGPEETGNLFMVGDVKQSIYRFRLAE PLLFLSKYKRFTESGEGTGRKIDLNKNFRSRADILDSTNFLFKQLMGGKIGEVDYDEQ AELKLGAAYPDNDETETELLLIDNAEDTDASEEAEELETVQFEAKAIAKEIRKLISSP FKVYDGKKKTHRNIQYRDIVILLRSMPWAPQIMEELRAQGIPVYANLTSGYFEAVEVA VALSVLKVIDNPYQDIPLASVLRSPIVGADENELSLIRLENKKAPYYEAMKDYLAAGD RSDELYQKLNTFYGHLQKWRAFSKNHSVSELIWEVYRDTKYMDYVGGMPGGKQRQANL RVLYDRARQYESTAFRGLFRFLRFIERMQERGDDLGTARALSEQEDVVRLMTIHSSKG LEFPVVFVAGLGRNFNMMDLNKSYLLDKELGFGTKYIHPQLRISYPTLPLIAMKKKMR RELLSEELRVLYVALTRAKEKLFLIGSCKDHQKQLAKWQASASQTDWLLPEFDRYQAR TYLDFIGPALARHRDLGDLAGVPAHADISGHPARFAVQMIHSYDLLDDDLEERMEEKS ERLEAIRRGEPVPGSFAFDEKAREQLSWTYPHQEVTQIRTKQSVSEIKRKREYEDEYS GRAPVKPADGSILYRRPAFMMKKGLTAAEKGTAMHTVMQHIPLSHVPSIEEAEQTVHR LYEKELLTEEQKDAIDIEEIVQFFHTEIGGQLIGAKWKDREIPFSLALPAKEIYPDAH EADEPLLVQGIIDCLYETEDGLYLLDYKSDRIEGKFQHGFEGAAPILKKRYETQIQLY TKAVEQIAKTKVKGCALYFFDGGHILTL*" /label="addA CDS" gene 1064032..1067730 /gene="addA" /locus_tag="BSU_10630" /old_locus_tag="BSU10630" /label="addA gene" S_feature 1067731..1067801 /Source="Nicolas_S_feature" /locus_tag="new_1143506_1143576" /HighExp="H2O2, C90, Heat, LBGtran, dia15, HiTm, Diami, C30, Lbtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S378" CDS 1067802..1068977 /gene="sbcD" /locus_tag="BSU_10640" /old_locus_tag="BSU10640" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7968921, 8493111, 16780573" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7968921, 8493111, 16780573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA repair exonuclease" /protein_id="NP_388945.3" /db_xref="EnsemblGenomes-Gn:BSU10640" /db_xref="EnsemblGenomes-Tr:CAB12904" /db_xref="GOA:P23479" /db_xref="InterPro:IPR004593" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR026843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG10467" /db_xref="UniProtKB/Swiss-Prot:P23479" /translation="MRILHTADWHLGKTLEGRSRLSEQADVLDELNTIVKDEQIDAIV MAGDAFDTVNPPALAEQLFYESLSALSDRGKRPIVVIAGNHDNPDRLSAASPLTHENG IHLIGYPTTEPIHIEVPSAGELLAVGALAYPSEARLNEVLSDTFDEKLLRDHYDVKIR QAFEHMTSRFRTDAVKIAASHIYVAGGNQTDSERPIEVGGAYTVAAESLPADAAYVAL GHLHRPQTIKRARTLARYSGSPLAYSFSEAGYAKSVTIVDAKPGEEATWQEVLLSSGK PLVKWKAANGLSEVYSWLDEGRDQNAWIDLEIRVADQLSLEEIHRLRKAHPGFIHIRP VFEEQNKDRERIEVKHVSIEDRFKKFYEKQTGGAVPDEEMVKLFLELASGVEEEDAK* " /label="sbcD CDS" gene 1067802..1068977 /gene="sbcD" /locus_tag="BSU_10640" /old_locus_tag="BSU10640" /label="sbcD gene" CDS 1068974..1072366 /gene="sbcC" /locus_tag="BSU_10650" /old_locus_tag="BSU10650" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16780573, 19906728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16780573, 19906728; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA ATP-dependent repair enzyme" /protein_id="NP_388946.2" /db_xref="EnsemblGenomes-Gn:BSU10650" /db_xref="EnsemblGenomes-Tr:CAB12905" /db_xref="GOA:O06714" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13088" /db_xref="UniProtKB/Swiss-Prot:O06714" /translation="MKPIALSIKGLHSFREEQTIDFEGLSGAGVFGIFGPTGSGKSSI LDAMTLALYGKVERAANNTHGILNHAEDTLSVSFTFALQTNHQISYKVERVFKRTDEM KVKTALCRFIEIKDEHTVLADKASEVNKRVEELLGLTIDDFTRAVVLPQGKFAEFLSL KGAERRHMLQRLFNLEQYGDRLVKKLRRQAQEANARKNEMLAEQSGLGEASSEAVEQA EKVLEQAEARLEAMRKNRDQAKERFTEHQEIWNVQKEKSTYEEEEKRLAEEQPHIDSM QKRLLEAETAAALKPYADRYAEAIQHEEQAEKEQTLAQKDLADRTAFFQQKHEEYEAW RQHKSEKEPELLAKQEQLSRLQEIEIKLSEAKQEEERKKADLRQKEEALQSVMNELET VTDRLTRGQNRQTELKQQLKSLQVTSDERKSCQQAAEMALRIRQTEEQIKKEKKRSEE LNLVLQKMNEEKNTLVQKTEAEENNIIQAYEAVQTVYHLVCETERSLTRMTEEARKSQ HTLHLQREKARVALLTKELAQKLTAGKPCPVCGSTDHDPSASVHETYEADSHLEEDIK RTDVLLTEAAALSQEILSAKIMLEEQSARFIEQCPFLQTIQAQNLEAAASFEHQPVYE AFETAKFEWKRIKQDILSVKTRMAQMIGAYQESLKKAEQLNEKIGFEKREADRIESII SELQSSMDSSLNMFKEAFQNQSVDEAEKWQQAIEEKDRAAEECEKRIEKSIAFLAEHE AQKEKLRESGHRLEREKLELHYAAERIKSVIADYEHELGDYAKGDSIQIKLRSVQQDL KLLKEKEQSLYEELQSAQMKLNQAKSRASASELTLQEAKGRLEKAKAAWLEHTKNTSI TRTEEVEQSLIPADELEKMKTGIDQFMDKLKQNAANLKRVAEILAGRALSESEWNETV AALQEAEDAFGAAIEEKGAAAKALAVIRDHHKRFNEIEAELKKWQMHIDRLDKLQAVF KGNTFVEFLAEEQLESVARDASARLSMLTRQRYAIEVDSEGGFVMRDDANGGVRRPVS SLSGGETFLTSLSLALALSAQIQLRGEYPLQFFFLDEGFGTLDQDLLDTVVTALEKLQ SDNLAVGVISHVQELRARLPKKLIVHPAEPSGRGTRVSLELM*" /label="sbcC CDS" gene 1068974..1072366 /gene="sbcC" /locus_tag="BSU_10650" /old_locus_tag="BSU10650" /label="sbcC gene" promotor_-35 1071621..1071627 /Source="Nicolas_upshift_promotors" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1071642..1071653 /Source="Nicolas_upshift_promotors" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1071649 /Source="Nicolas_upshifts" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1071718..1072691) /Source="Nicolas_S_feature" /locus_tag="new_1147493_1148466_c" /HighExp="S6, S8, S7, BT, C30, B36, S5, C90, Pyr, B60" /AntisenseName="yisB" /AntisenseCor="0.19649597897587401" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="SigK" /TUlongPSig="0.992" /label="S379" CDS 1072380..1072682 /gene="hlpB" /locus_tag="BSU_10660" /old_locus_tag="BSU10660" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16780573, 22984257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16780573, 22984257; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="HNH nuclease-like essential for DNA repair" /protein_id="NP_388947.1" /db_xref="EnsemblGenomes-Gn:BSU10660" /db_xref="EnsemblGenomes-Tr:CAB12906" /db_xref="SubtiList:BG13089" /db_xref="UniProtKB/Swiss-Prot:O06715" /translation="MAKQIAGICELCGRSDVQLTEHHLTPKEEGGTFLPTAMLCIPCH KQIHALYTNQELAVRLNGMAELRSDPELARFVKWIRKQPPEKLIKTKKSNERKKKK*" /label="hlpB CDS" gene 1072380..1072682 /gene="hlpB" /locus_tag="BSU_10660" /old_locus_tag="BSU10660" /label="hlpB gene" downshifts 1072662 /Source="Nicolas_upshifts" /id="D579" /incds=0 /nref=230 /ntot=269 /MaxReadThrough="1.42126" /MaxDrop="6.71114" /score="0.317490594" /energy="-14.3" /TU="NA" /idTUdmin="U861" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1072719..1072937) /gene="gerPF" /locus_tag="BSU_10670" /old_locus_tag="BSU10670" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007, 20161744" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007, 20161744; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388948.2" /db_xref="EnsemblGenomes-Gn:BSU10670" /db_xref="EnsemblGenomes-Tr:CAB12907" /db_xref="GOA:O06716" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13090" /db_xref="UniProtKB/Swiss-Prot:O06716" /translation="MPAIVGPIAINSISGGVVNFGDSFYLSPKSSSKSALGSGAGNTG DFLLLNNAVNATNYIDPDVNDQDMVGNG*" /label="gerPF CDS" gene complement(1072719..1072937) /gene="gerPF" /locus_tag="BSU_10670" /old_locus_tag="BSU10670" /label="gerPF gene" downshifts complement(1072736) /Source="Nicolas_upshifts" /id="D580" /incds=0 /nref=40 /ntot=66 /MaxReadThrough="3.93344" /MaxDrop="5.39228" /score="13.5435041" /energy="-15.3" /TU="U863" /idTUdmin="U863" /TUdmin="-989" /isTUend="FALSE" /label="downshifts" CDS complement(1072969..1073370) /gene="gerPE" /locus_tag="BSU_10680" /old_locus_tag="BSU10680" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388949.1" /db_xref="EnsemblGenomes-Gn:BSU10680" /db_xref="EnsemblGenomes-Tr:CAB12908" /db_xref="GOA:O06717" /db_xref="InterPro:IPR024496" /db_xref="SubtiList:BG13091" /db_xref="UniProtKB/Swiss-Prot:O06717" /translation="MLKRISRIRLVKFNSLGIASVFQVGDTNEIDMSVKVFAVQRSLS TFYHNEGSFNKKEYQIFQQQAVKPLPETGVQSAFCHEVPAIYVRSIKIQGVSASSVLH AGSASLIRGDARLKHIRQIQSPRSQSPAKNI*" /label="gerPE CDS" gene complement(1072969..1073370) /gene="gerPE" /locus_tag="BSU_10680" /old_locus_tag="BSU10680" /label="gerPE gene" CDS complement(1073370..1073546) /gene="gerPD" /locus_tag="BSU_10690" /old_locus_tag="BSU10690" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388950.1" /db_xref="EnsemblGenomes-Gn:BSU10690" /db_xref="EnsemblGenomes-Tr:CAB12909" /db_xref="GOA:O06718" /db_xref="InterPro:IPR017257" /db_xref="SubtiList:BG13092" /db_xref="UniProtKB/Swiss-Prot:O06718" /translation="MIFTVINRSLEVGDIRMNGVSSSSVFHIGDTESIYLSSIFDTPP ESLIIGPFAPLAPE*" /label="gerPD CDS" gene complement(1073370..1073546) /gene="gerPD" /locus_tag="BSU_10690" /old_locus_tag="BSU10690" /label="gerPD gene" CDS complement(1073543..1074160) /gene="gerPC" /locus_tag="BSU_10700" /old_locus_tag="BSU10700" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388951.1" /db_xref="EnsemblGenomes-Gn:BSU10700" /db_xref="EnsemblGenomes-Tr:CAB12910" /db_xref="GOA:O06719" /db_xref="InterPro:IPR019673" /db_xref="SubtiList:BG13093" /db_xref="UniProtKB/Swiss-Prot:O06719" /translation="MYDQSVSSYLQNLNSFVQQQAIHIQQLERQLKEIQTEMNTMKQR PATTIERVEYKFDQLKIERLDGTLNIGLNPTDPNSVQNFDVSQSTPQIGMMQQEESAQ LMQQIRQNVDMYLTEEIPDILEQLENQYDSRLDDTNRHHVIEDIRKQMDSRIHYYMSH IKKEENTPPAQYAEHIAEHVKRDVIRAVEHFLEHIPSEMKGDEQA*" /label="gerPC CDS" gene complement(1073543..1074160) /gene="gerPC" /locus_tag="BSU_10700" /old_locus_tag="BSU10700" /label="gerPC gene" CDS complement(1074183..1074416) /gene="gerPB" /locus_tag="BSU_10710" /old_locus_tag="BSU10710" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388952.2" /db_xref="EnsemblGenomes-Gn:BSU10710" /db_xref="EnsemblGenomes-Tr:CAB12911" /db_xref="GOA:O06720" /db_xref="InterPro:IPR024255" /db_xref="SubtiList:BG13094" /db_xref="UniProtKB/Swiss-Prot:O06720" /translation="MNFYINQTIQINYLRLESISNSSILQIGSAGSIKSLSNLYNTGS YVEPAPEVSGSGQPLQLQEPDTGSLVPLQPPGR*" /label="gerPB CDS" gene complement(1074183..1074416) /gene="gerPB" /locus_tag="BSU_10710" /old_locus_tag="BSU10710" /label="gerPB gene" CDS complement(1074431..1074652) /gene="gerPA" /locus_tag="BSU_10720" /old_locus_tag="BSU10720" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388953.1" /db_xref="EnsemblGenomes-Gn:BSU10720" /db_xref="EnsemblGenomes-Tr:CAB12912" /db_xref="GOA:O06721" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13095" /db_xref="UniProtKB/Swiss-Prot:O06721" /translation="MPAIVGAFKINAIGTSGVVHIGDCITISPQAQVRTFAGAGSFNT GDSLKVMNYQNATNVYDNDAVDQPIVANA*" /label="gerPA CDS" gene complement(1074431..1074652) /gene="gerPA" /locus_tag="BSU_10720" /old_locus_tag="BSU10720" /label="gerPA gene" S_feature complement(1074653..1074739) /Source="Nicolas_S_feature" /locus_tag="new_1150428_1150514_c" /HighExp="S6, S8, S7, S5, BT, B36, B60, G/S, Pyr, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="SigK" /TUlongPSig="0.992" /label="S380" promotor_-35 1074667..1074673 /Source="Nicolas_upshift_promotors" /id="U862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.733266733266733" /xcortree=136 /SigmaFactorBS="aaacgctccgacaatggccggcatacgagcacatccttTGTT GAAaaattaaaaaaagACAGGTAAAGTGAAATGACAattccgatttcaattgggctat t" /listShort="S381, S385" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1074687..1074706 /Source="Nicolas_upshift_promotors" /id="U862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.733266733266733" /xcortree=136 /SigmaFactorBS="aaacgctccgacaatggccggcatacgagcacatccttTGTT GAAaaattaaaaaaagACAGGTAAAGTGAAATGACAattccgatttcaattgggctat t" /listShort="S381, S385" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1074689..1075344 /Source="Nicolas_S_feature" /locus_tag="new_1150464_1151119" /HighExp="Salt, BC, Sw, S8, Heat, M9-stat, S7, Etha, BMM, Lbtran" /AntisenseName="yisI" /AntisenseCor="3.97396613023396E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="0.17396" /TUshortSig="SigA" /TUshortPSig="0.733" /TUlongSig="NA" /TUlongPSig="NA" /label="S381" upshifts 1074689 /Source="Nicolas_upshifts" /id="U862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.733266733266733" /xcortree=136 /SigmaFactorBS="aaacgctccgacaatggccggcatacgagcacatccttTGTT GAAaaattaaaaaaagACAGGTAAAGTGAAATGACAattccgatttcaattgggctat t" /listShort="S381, S385" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1074726..1074745) /Source="Nicolas_upshift_promotors" /id="U863" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1293 /SigmaFactorBS="ttcacaaagagccgatatgtccccttaaaattTCTCTCACAC atatgtgcgtttGTCATAAGCTATCGTGAATAgcccaattgaaatcggaattgtcatt t" /listShort="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1074739) /Source="Nicolas_upshifts" /id="U863" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1293 /SigmaFactorBS="ttcacaaagagccgatatgtccccttaaaattTCTCTCACAC atatgtgcgtttGTCATAAGCTATCGTGAATAgcccaattgaaatcggaattgtcatt t" /listShort="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1074741..1074870) /Source="Nicolas_S_feature" /locus_tag="new_1150516_1150645_c" /HighExp="S6, S8, S7, T5.0H, T3.30H, T4.0H, S5, T3.0H, T2.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S382" promotor_-35 complement(1074758..1074767) /Source="Nicolas_upshift_promotors" /id="U863" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1293 /SigmaFactorBS="ttcacaaagagccgatatgtccccttaaaattTCTCTCACAC atatgtgcgtttGTCATAAGCTATCGTGAATAgcccaattgaaatcggaattgtcatt t" /listShort="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1074872..1075074) /Source="Nicolas_S_feature" /locus_tag="new_1150647_1150849_c" /HighExp="T5.0H, T4.0H, T3.30H, S6, M9-stat, T3.0H, S8, S7, T2.30H, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.976, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S383" downshifts complement(1074915) /Source="Nicolas_upshifts" /id="D581" /incds=0 /nref=13 /ntot=116 /MaxReadThrough="3.97434" /MaxDrop="3.59184" /score="13.5435041" /energy="-15.3" /TU="U865" /idTUdmin="U864" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1075075..1075245) /gene="pchI" /locus_tag="BSU_10730" /old_locus_tag="BSU10730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11679073, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11679073, 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Spo0A-P phosphatase (iron-metabolism related)" /protein_id="NP_388954.1" /db_xref="EnsemblGenomes-Gn:BSU10730" /db_xref="EnsemblGenomes-Tr:CAB12913" /db_xref="GOA:O06722" /db_xref="InterPro:IPR018540" /db_xref="InterPro:IPR037208" /db_xref="SubtiList:BG13096" /db_xref="UniProtKB/Swiss-Prot:O06722" /translation="MNSKIEEMRITLIETAQKYGMNSKETIQCSQELDILLNTRIKEE MIFGRYLENSRM*" /label="pchI CDS" gene complement(1075075..1075245) /gene="pchI" /locus_tag="BSU_10730" /old_locus_tag="BSU10730" /label="pchI gene" misc_feature complement(1075289..1075308) /Source="Nicolas_upshift_promotors" /id="U864" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.386613386613387" /psig="0.976023976023976" /xcortree=2921 /SigmaFactorBS="gcttttttagtcaaattgacgaaaggcaaccttttgagccaa aaTAGGTTATACTAACGATATCctgtatttatatcaaaataaaatctagaattggaga t" /listShort="yisI, S383" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1075292) /Source="Nicolas_upshifts" /id="U864" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.386613386613387" /psig="0.976023976023976" /xcortree=2921 /SigmaFactorBS="gcttttttagtcaaattgacgaaaggcaaccttttgagccaa aaTAGGTTATACTAACGATATCctgtatttatatcaaaataaaatctagaattggaga t" /listShort="yisI, S383" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1075294..1075390) /Source="Nicolas_S_feature" /locus_tag="new_1151069_1151165_c" /HighExp="S6, S8, S7, S5, BT, Pyr, G/S, Glucon, SMMPr, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S384" downshifts 1075301 /Source="Nicolas_upshifts" /id="D582" /incds=0 /nref=3 /ntot=54 /MaxReadThrough="4.52913" /MaxDrop="3.35342" /score="12.6645711" /energy="-10.3" /TU="U862" /idTUdmin="U862" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" S_feature 1075346..1075510 /Source="Nicolas_S_feature" /locus_tag="new_1151121_1151285" /HighExp="Salt, S8, S7, BC, Heat, H2O2, Sw, Oxctl, MG-0.2, MG-0.1" /AntisenseName="yisJ" /AntisenseCor="0.24461808844813801" /AntisenseRegPval="-4.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.733" /TUlongSig="NA" /TUlongPSig="NA" /label="S385" CDS complement(1075391..1076314) /gene="yisJ" /locus_tag="BSU_10740" /old_locus_tag="BSU10740" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein, CotH paralog" /protein_id="NP_388955.1" /db_xref="EnsemblGenomes-Gn:BSU10740" /db_xref="EnsemblGenomes-Tr:CAB12914" /db_xref="GOA:O06723" /db_xref="InterPro:IPR014867" /db_xref="SubtiList:BG13097" /db_xref="UniProtKB/Swiss-Prot:O06723" /translation="MERVHLFFHREQLKRKGTAKGLFVTDRSVSPILLTQRDRAEKAS YEISWEKSLLGERTLFLNAEQDDPSLMRRRLAYCFFDQIGVPAPVASYSFLTINGQPE GIYLNIKNHQPAGKRSYGVKTADPRVPLSLFNNDSSAFLHEFFILIRTAGDDELAERI KLYLDVKLFFLWLIGNTCTNQGFYYTFCLNESGRLYVSPMETRSLAVQEWYEEDPLLT KGKTLSSRLLSIPAFRSQYHTLMKNVLKRSFTIERLSPLINEWHLDICQSAADDPFIK KSPFQIEKEQTNILREIEERQDFLQAHLARL*" /label="yisJ CDS" gene complement(1075391..1076314) /gene="yisJ" /locus_tag="BSU_10740" /old_locus_tag="BSU10740" /label="yisJ gene" promotor_-10 complement(1076336..1076355) /Source="Nicolas_upshift_promotors" /id="U865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1372 /SigmaFactorBS="aaatccctttttctcaattccgttttcatTTCGTTTCAGgac gggcttgctcTACATATCATACAAATGTCGttttgagaaggaggaaagaatatggagc g" /listShort="yisJ, S384, yisI, S383, S382" /listLong="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /label="promotor_-10" upshifts complement(1076347) /Source="Nicolas_upshifts" /id="U865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1372 /SigmaFactorBS="aaatccctttttctcaattccgttttcatTTCGTTTCAGgac gggcttgctcTACATATCATACAAATGTCGttttgagaaggaggaaagaatatggagc g" /listShort="yisJ, S384, yisI, S383, S382" /listLong="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /label="upshifts" promotor_-35 complement(1076369..1076378) /Source="Nicolas_upshift_promotors" /id="U865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1372 /SigmaFactorBS="aaatccctttttctcaattccgttttcatTTCGTTTCAGgac gggcttgctcTACATATCATACAAATGTCGttttgagaaggaggaaagaatatggagc g" /listShort="yisJ, S384, yisI, S383, S382" /listLong="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /label="promotor_-35" promotor_-35 1076398..1076406 /Source="Nicolas_upshift_promotors" /id="U866" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=553 /SigmaFactorBS="cccgtcctgaaacgaaatgaaaacggaattgagaaAAAGGGA TTtcagcattcgaCAGAGAATACATGAAGGAGcattctgatttaaaagatgatggagg a" /listShort="yisK, S386, yisL" /listLong="wprA" /label="promotor_-35" promotor_-10 1076418..1076436 /Source="Nicolas_upshift_promotors" /id="U866" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=553 /SigmaFactorBS="cccgtcctgaaacgaaatgaaaacggaattgagaaAAAGGGA TTtcagcattcgaCAGAGAATACATGAAGGAGcattctgatttaaaagatgatggagg a" /listShort="yisK, S386, yisL" /listLong="wprA" /label="promotor_-10" upshifts 1076423 /Source="Nicolas_upshifts" /id="U866" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=553 /SigmaFactorBS="cccgtcctgaaacgaaatgaaaacggaattgagaaAAAGGGA TTtcagcattcgaCAGAGAATACATGAAGGAGcattctgatttaaaagatgatggagg a" /listShort="yisK, S386, yisL" /listLong="wprA" /label="upshifts" CDS 1076469..1077374 /gene="mblK" /locus_tag="BSU_10750" /old_locus_tag="BSU10750" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16847875, 27215790, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16847875, 27215790, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydrolase/isomerase involved in remodelling the bacterial envelope" /protein_id="NP_388956.1" /db_xref="EnsemblGenomes-Gn:BSU10750" /db_xref="EnsemblGenomes-Tr:CAB12915" /db_xref="GOA:O06724" /db_xref="InterPro:IPR011234" /db_xref="InterPro:IPR036663" /db_xref="SubtiList:BG13098" /db_xref="UniProtKB/Swiss-Prot:O06724" /translation="MKFATGELYNRMFVGLIIDDEKIMDLQKAEKKLFELETIPGSLI ECIAEGDKFVAHARQLAEWAKKPNDELGSFMYSLSEVKLHAPIPKPSKNIICIGKNYR DHAIEMGSEADIPEHPMVFTKSPVTVTGHGDIVKSHEEVTSQLDYEGELAVVIGKSGT RISKEDAYDHVFGYTIVNDITARDLQKRHKQFFIGKSLDTTCPMGPVLVHKSSIQEPE RLKVETRVNGELRQSGSASDMIFSIPELIETLSKGMTLEAGDIIATGTPSGVGKGFTP PKFLRSGDKIDITIDPIGTLSNQIG*" /label="mblK CDS" gene 1076469..1077374 /gene="mblK" /locus_tag="BSU_10750" /old_locus_tag="BSU10750" /label="mblK gene" S_feature 1077375..1077455 /Source="Nicolas_S_feature" /locus_tag="new_1153150_1153230" /HighExp="S2, Lbstat, S1, Etha, SMMPr, M0t90, M40t90, LoTm, T-4.40H, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S386" promotor_-35 1077425..1077428 /Source="Nicolas_upshift_promotors" /id="U867" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=2462 /SigmaFactorBS="gacccgcccgttttttctgataatcatcTTTGtgacagagga caagttCATGGTACTATAAGTGGGGTaatttatctgatagggggaacatatatgacac a" /listShort="yisL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1077445..1077464 /Source="Nicolas_upshift_promotors" /id="U867" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=2462 /SigmaFactorBS="gacccgcccgttttttctgataatcatcTTTGtgacagagga caagttCATGGTACTATAAGTGGGGTaatttatctgatagggggaacatatatgacac a" /listShort="yisL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1077457 /Source="Nicolas_upshifts" /id="U867" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=2462 /SigmaFactorBS="gacccgcccgttttttctgataatcatcTTTGtgacagagga caagttCATGGTACTATAAGTGGGGTaatttatctgatagggggaacatatatgacac a" /listShort="yisL" /GFF_Attribute="listLong" /label="upshifts" CDS 1077490..1077846 /gene="yisL" /locus_tag="BSU_10760" /old_locus_tag="BSU10760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 27215790; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388957.1" /db_xref="EnsemblGenomes-Gn:BSU10760" /db_xref="EnsemblGenomes-Tr:CAB12916" /db_xref="GOA:O06725" /db_xref="InterPro:IPR010899" /db_xref="SubtiList:BG13099" /db_xref="UniProtKB/Swiss-Prot:O06725" /translation="MTHLHITTWVVALILLFVSYSLYSSGSAKGAKITHMILRLFYIL IILTGAELFVRFANWNGEYAGKMILGIITIGLMEMLLIRKKKEKSTGGLWVGFVIVLL LTVLLGLHLPIGFQLF*" /label="yisL CDS" gene 1077490..1077846 /gene="yisL" /locus_tag="BSU_10760" /old_locus_tag="BSU10760" /label="yisL gene" downshifts 1077743 /Source="Nicolas_upshifts" /id="D583" /incds=1 /nref=1 /ntot=44 /MaxReadThrough="4.28837" /MaxDrop="2.46999" /score="41.4247437" /energy="-11.7" /TU="U866,U867" /idTUdmin="U867" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts 1077834 /Source="Nicolas_upshifts" /id="D584" /incds=0 /nref=17 /ntot=162 /MaxReadThrough="3.06092" /MaxDrop="3.41506" /score="41.4247437" /energy="-11.7" /TU="U866" /idTUdmin="U867" /TUdmin=3 /isTUend="TRUE" /label="downshifts" upshifts 1077967 /Source="Nicolas_upshifts" /id="U868" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.486513486513487" /psig="0.732267732267732" /xcortree=2782 /SigmaFactorBS="atattccaaatcatttaaaataaccttaaaattccctgtaag cggtatctcgtcctatgaaatTATGATACCTTCAAGGAGATtcattattttgcaggag g" /listShort="wprA" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1077970..1077989 /Source="Nicolas_upshift_promotors" /id="U868" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.486513486513487" /psig="0.732267732267732" /xcortree=2782 /SigmaFactorBS="atattccaaatcatttaaaataaccttaaaattccctgtaag cggtatctcgtcctatgaaatTATGATACCTTCAAGGAGATtcattattttgcaggag g" /listShort="wprA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1078014..1080698 /gene="wprA" /locus_tag="BSU_10770" /old_locus_tag="BSU10770" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9004506, 9675284, 10336490, 15205417, 17269748, 21636651, 23180473, 25313396" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9004506, 9675284, 10336490, 15205417, 17269748, 21636651, 23180473, 25313396; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cell wall-associated protease" /protein_id="NP_388958.1" /db_xref="EnsemblGenomes-Gn:BSU10770" /db_xref="EnsemblGenomes-Tr:CAB12917" /db_xref="GOA:P54423" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034084" /db_xref="InterPro:IPR036852" /db_xref="SubtiList:BG11846" /db_xref="UniProtKB/Swiss-Prot:P54423" /translation="MKRRKFSSVVAAVLIFALIFSLFSPGTKAAAAGAIDQAAALENG KEQTGAMKEPEQVKWYKVTPGATDIQKNSHMALTVKSDSVLNVSVYPSKEKALKDETF EMYRSFTAEDGKSEVIFPYAWSGPYYVKVEYLGEEEPEDGGTAEAAAEAKYTIGYKGT KKQPSDLEEEEACPVEMSVDQKKSGKGILDKLRSIRDEQLSQTAEGKELTSLYYKAAP FIVAKLALNKTARNEIYQDLVTLKPLFDDVSENGASSSYKVTEKDQKAINRLYDKALQ SVPSFLKEEIKKQADRLNMKQLQGKTAGAILTENNIAAKSEVQTTKVIFKVKDNKSLS SVHNEMKGFSASAQSKKDISNVKKAKKLFDNLYSFELPKDEKQNGAYTASAKRVKSAA ATLSKMSNVEFAEPVQEYKSLANDIQYPYQWPLKNNGENGGVKNADVKYEPANTLLSK RKLNDTLIAVVDTGVDSTLADLKGKVRTDLGHNFVGRNNNAMDDQGHGTHVAGIIAAQ SDNGYSMTGLNAKAKIIPVKVLDSAGSGDTEQIALGIKYAADKGAKVINLSLGGGYSR VLEFALKYAADKNVLIAAASGNDGENALSYPASSKYVMSVGATNRMDMTADFSNYGKG LDISAPGSDIPSLVPNGNVTYMSGTSMATPYAAAAAGLLFAQNPKLKRTEVEDMLKKT ADDISFESVDGGEEELYDDYGDPIEIPKTPGVDWHSGYGRLNVMKAVSAADLQLKVNK LESTQTAVRGSAKEGTLIEVMNGKKKLGSAKAGKDNAFKVNIATQKQDQVLYLKATKG DAKTSYKVVVVKGKPSGTPKVNAVKTKDTAVKGKANSKAMIRVKNKSKKVIASAKADA KGTFSVKIKKQKAGTVLYVTAVDTDKKESKEAKVVVEK*" /label="wprA CDS" gene 1078014..1080698 /gene="wprA" /locus_tag="BSU_10770" /old_locus_tag="BSU10770" /label="wprA gene" downshifts complement(1078182) /Source="Nicolas_upshifts" /id="D585" /incds=1 /nref=2 /ntot=155 /MaxReadThrough="0.14981" /MaxDrop="3.98572" /score="9.01750245" /energy="-8" /TU="NA" /idTUdmin="U869" /TUdmin=2563 /isTUend="FALSE" /label="downshifts" downshifts 1080690 /Source="Nicolas_upshifts" /id="D586" /incds=0 /nref=239 /ntot=267 /MaxReadThrough="1.55031" /MaxDrop="8.31576" /score="36.3638154" /energy="-12.3" /TU="NA" /idTUdmin="U868" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1080729..1081316) /gene="yisN" /locus_tag="BSU_10780" /old_locus_tag="BSU10780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388959.1" /db_xref="EnsemblGenomes-Gn:BSU10780" /db_xref="EnsemblGenomes-Tr:CAB12918" /db_xref="InterPro:IPR024488" /db_xref="SubtiList:BG12239" /db_xref="UniProtKB/Swiss-Prot:O06727" /translation="MKKKETAWMKRKQLLYTEERKWEYGTILIEDGICLIENGEGDIL LADSLQHSPIWIHHKGKWEQAGFQDKLVLACGAENISLSGGERIRYEKSVKRPLMALL DSLDDETFLAFLQHLHSFGLSVFDCVFSYNKGVFSNTSAGQGVSFYHFSNDTAQCAMQ HHYNYSSEGTGDRFEWTASNGKRSIMYTAVQRGRK*" /label="yisN CDS" gene complement(1080729..1081316) /gene="yisN" /locus_tag="BSU_10780" /old_locus_tag="BSU10780" /label="yisN gene" promotor_-10 complement(1081331..1081350) /Source="Nicolas_upshift_promotors" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1081350) /Source="Nicolas_upshifts" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1081366..1081368) /Source="Nicolas_upshift_promotors" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1081371..1081377 /Source="Nicolas_upshift_promotors" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1081389 /Source="Nicolas_upshifts" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1081392..1081410 /Source="Nicolas_upshift_promotors" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1081395..1081461 /Source="Nicolas_S_feature" /locus_tag="new_1157170_1157236" /HighExp="S6, S5, S7, S8, B36, S4, BT, G/S, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.543" /TUlongSig="NA" /TUlongPSig="NA" /label="S387" CDS 1081462..1083306 /gene="asnO" /locus_tag="BSU_10790" /old_locus_tag="BSU10790" /EC_number="6.3.5.4" /function="16.5: Explore" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparagine synthetase (sporulation related)" /protein_id="NP_388960.2" /db_xref="EnsemblGenomes-Gn:BSU10790" /db_xref="EnsemblGenomes-Tr:CAB12919" /db_xref="GOA:O05272" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG12240" /db_xref="UniProtKB/Swiss-Prot:O05272" /translation="MCGITGWVDFKKQLVQEKQTMDRMTDTLSKRGPDDSNVWGEHHV LFGHKRLAVVDIEGGRQPMACTYKGDTYTIIYNGELYNTEDLRKELRARGHQFERTSD TEVLLHSYIEWQEDCVDHLNGIFAFAVWDEKRNLLFAARDRLGVKPFFYTKEGSSFLF GSEIKAILAHPDIKARVDRTGLSEIFGLGPSRTPGTGIFKGIKEIRPAHALTFSKDGL NIWRYWNVESEKHTDSFDDTVANVRSLFQDAVTRQLVSDVPVCTFLSGGLDSSAITAI AAGHFEKEGKAPLHTYSIDYEENDKYFQASAFQPNDDGPWIEKMTEAFGTTHHKCVIS QKDLVDHLEEAVLVKDLPGMADVDSSLLWFCREIKKDFVVSLSGECADEIFGGYPWFH TADVESGFPWMRSTEERIKLLSDSWQKKLNLKEYVNAKYEETLAETPLLDGETGVDKA RRQLFYLNMLWFMTNLLDRKDRMSMGASLEVRVPFADHRLVEYVWNIPWEMKMHDNRE KGILRKALEGILPDDILYRKKSPYPKTHHPEYTKGVSEWLKTIRSQKDSVLHTLLDRK QLDQLLETEGSSFKVPWFGQLMKGPQLIAHLAQIHTWFEAYRIDIDER*" /label="asnO CDS" gene 1081462..1083306 /gene="asnO" /locus_tag="BSU_10790" /old_locus_tag="BSU10790" /label="asnO gene" S_feature 1083307..1083374 /Source="Nicolas_S_feature" /locus_tag="new_1159082_1159149" /HighExp="S6, S5, S7, B36, BT, S8, S4, B60, S3, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.543" /TUlongSig="NA" /TUlongPSig="NA" /label="S388" downshifts 1083331 /Source="Nicolas_upshifts" /id="D587" /incds=0 /nref=12 /ntot=43 /MaxReadThrough="3.29969" /MaxDrop="4.67478" /score="3.55879494" /energy="-14.8" /TU="U870" /idTUdmin="U870" /TUdmin="-550" /isTUend="FALSE" /label="downshifts" CDS complement(1083436..1083915) /gene="yizA" /locus_tag="BSU_10800" /old_locus_tag="BSU10800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (sporulation related)" /protein_id="YP_054576.1" /db_xref="EnsemblGenomes-Gn:BSU10800" /db_xref="EnsemblGenomes-Tr:CAE01451" /db_xref="GOA:Q7WY73" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="PDB:2QE9" /db_xref="SubtiList:BG14187" /db_xref="UniProtKB/Swiss-Prot:Q7WY73" /translation="MMKFFEYNWQVRDQWFTWCHQLTTEELLKNRLGGVENILYTLFH IIDVEYSWIRAIQGKEDIAVQFADYQTLNKVKSLSNTFRTEIIDVLQTHSDQIKDELV SVPWETGVLYTRDEILHHIIAHEIHHIGQLSVWARELKLSPVSASFIGRTLKPIHSY* " /label="yizA CDS" gene complement(1083436..1083915) /gene="yizA" /locus_tag="BSU_10800" /old_locus_tag="BSU10800" /label="yizA gene" upshifts complement(1083935) /Source="Nicolas_upshifts" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1083939..1083957) /Source="Nicolas_upshift_promotors" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1083968..1083976) /Source="Nicolas_upshift_promotors" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1084107..1084111 /Source="Nicolas_upshift_promotors" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1084124 /Source="Nicolas_upshifts" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1084126..1084145 /Source="Nicolas_upshift_promotors" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1084147..1084971 /gene="farP" /locus_tag="BSU_10810" /old_locus_tag="BSU10810" /EC_number="3.6.1.27" /experiment="publication(s) with functional evidences, PMID:23295493, 25308276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23295493, 25308276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="farnesyl diphosphate phosphatase" /protein_id="NP_388961.1" /db_xref="EnsemblGenomes-Gn:BSU10810" /db_xref="EnsemblGenomes-Tr:CAB12920" /db_xref="GOA:O06728" /db_xref="InterPro:IPR002060" /db_xref="InterPro:IPR008949" /db_xref="PDB:3WE9" /db_xref="SubtiList:BG12241" /db_xref="UniProtKB/Swiss-Prot:O06728" /translation="MIHRSEKMKEIKEAYQQCGQIVGEYAPACFKALSYLPLKQRQAS WAVLSFCHTAASADEKVLPAFEAKADHVYQRTNNGKQHLWKAFDHAYRTFTLESEPFR EFIAAQKEDAKPYDDLDELLMYAYRTGGAAGLMLLPILTRRKQDQLKQAAVSLGLAIQ LVRFLSDLGTDQQKNRIPRQVMQQFGYTEADLQKGTVNKAFTMTWEYIAFEAEAYLEE CQDALPLFPQYSQKTVKAALHLHRAVLEKIRAKQHDVFQYHFALTETEVKQILSDI*" /label="farP CDS" gene 1084147..1084971 /gene="farP" /locus_tag="BSU_10810" /old_locus_tag="BSU10810" /label="farP gene" promotor_-35 1084359..1084365 /Source="Nicolas_upshift_promotors" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1084380..1084398 /Source="Nicolas_upshift_promotors" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1084387 /Source="Nicolas_upshifts" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1084981..1086431 /Source="Nicolas_S_feature" /locus_tag="new_1160756_1162206" /HighExp="Salt, Etha, Sw, Cold, G150, G180, G135, LBGtran, Heat, Paraq" /AntisenseName="yisQ" /AntisenseCor="0.19511630802652" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S389" CDS complement(1085001..1086368) /gene="yisQ" /locus_tag="BSU_10820" /old_locus_tag="BSU10820" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na(+)-driven efflux transporter" /protein_id="NP_388962.1" /db_xref="EnsemblGenomes-Gn:BSU10820" /db_xref="EnsemblGenomes-Tr:CAB12921" /db_xref="GOA:O07940" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG12242" /db_xref="UniProtKB/Swiss-Prot:O07940" /translation="MKQAVFKSTALKKPADKTFSLFSLTWPIFIEVSLYMFMGNADTL MLSQYSDNSVAAVGVSNQILNLIIVMFSFIATGTTVIISQFLGSRQKKEAMEVAYVSI GANFFISLAISAVVFFAAVPLLHMMGLSDALMPDAKVFLQVVGGLSFIQALIMTFSAI LKSYGYTKDTMFVTIGMNILNIAGNFVVIFGLFGFPVLGVAGVAMSTSIARVIGLIAM IVIVNKRIQLKMSLKKVFHMHKEHLRKLLKIGIPSAGEQLSYNLSQMIVTYFIAIMGA QALTTKVYTQNITMFILLFGTAISQGTQILIGRYIGGKQFDAAYERCMKSLYWALGIA AATSVLMTIFSKDLIGLFTQSPDIIATASLLIAMTIILEPGRSFNVIIINSLRAAGDA KFPVYMAMISMWGIGLPLAYLFGIHLGFGLAGIWISFIADEWVRGILMYRRWRSRIWI QKGMA*" /label="yisQ CDS" gene complement(1085001..1086368) /gene="yisQ" /locus_tag="BSU_10820" /old_locus_tag="BSU10820" /label="yisQ gene" promotor_-35 1086400..1086407 /Source="Nicolas_upshift_promotors" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1086421..1086440 /Source="Nicolas_upshift_promotors" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1086433 /Source="Nicolas_upshifts" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="upshifts" CDS 1086492..1087355 /gene="yisR" /locus_tag="BSU_10830" /old_locus_tag="BSU10830" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388963.1" /db_xref="EnsemblGenomes-Gn:BSU10830" /db_xref="EnsemblGenomes-Tr:CAB12922" /db_xref="GOA:P40331" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG11064" /db_xref="UniProtKB/Swiss-Prot:P40331" /translation="MPRILFTVPPFPVFIAAGEGVFKKGETHVKRVFSVFDLIYVKQG TLYITENETSFSVEGGEYILLSPGLEHYGTKGSDEATSYYWLHFDEHRYEFTAKGGSN WSELQQEKGSFEELARYGLALPRKGKVQRPQFMAQQFEKLIDYSAENSDLPLRKQILF EELMLHLQKEAFQIPSAKERVAWEAARYLQEHYKEKTTIKDLSLALHYHQDYVSRCMQ QVLGVTPAQYTNRVRMTEAKRLLSSTNDKMGVIAETVGMEDPTYFSKLFKQIEGISPI EYRKIVSRKVQ*" /label="yisR CDS" gene 1086492..1087355 /gene="yisR" /locus_tag="BSU_10830" /old_locus_tag="BSU10830" /label="yisR gene" CDS 1087373..1088386 /gene="iolQ" /locus_tag="BSU_10840" /old_locus_tag="BSU10840" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8407808, 23504016, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8407808, 23504016, 28693424; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of iolX (LacI family)" /protein_id="NP_388964.1" /db_xref="EnsemblGenomes-Gn:BSU10840" /db_xref="EnsemblGenomes-Tr:CAB12923" /db_xref="GOA:P37947" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10847" /db_xref="UniProtKB/Swiss-Prot:P37947" /translation="MKTTIYDVAKAAGVSITTVSRVINNTGRISDKTRQKVMNVMNEM AYTPNVHAAALTGKRTNMIALVAPDISNPFYGELAKSIEERADELGFQMLICSTDYDP KKETKYFSVLKQKKVDGIIFATGIESHDSMSALEEIASEQIPIAMISQDKPLLPMDIV VIDDVRGGYEAAKHLLSLGHTNIACIIGDGSTTGEKNRIKGFRQAMEEAGVPIDESLI IQTRFSLESGKEEAGKLLDRNAPTAIFAFNDVLACAAIQAARIRGIKVPDDLSIIGFD NTILAEMAAPPLTTVAQPIKEMGRSVIELLAEAIEGKRKAKQKIVLPPELVVRHSTSP LNT*" /label="iolQ CDS" gene 1087373..1088386 /gene="iolQ" /locus_tag="BSU_10840" /old_locus_tag="BSU10840" /label="iolQ gene" downshifts 1088369 /Source="Nicolas_upshifts" /id="D588" /incds=0 /nref=13 /ntot=204 /MaxReadThrough="0.51227" /MaxDrop="3.29173" /score="25.1260914" /energy="-9.6" /TU="NA" /idTUdmin="U874" /TUdmin=22 /isTUend="TRUE" /label="downshifts" promotor_-35 1088438..1088445 /Source="Nicolas_upshift_promotors" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1088460..1088479 /Source="Nicolas_upshift_promotors" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1088479..1088594 /Source="Nicolas_S_feature" /locus_tag="new_1164254_1164369" /HighExp="Lbstat, M40t90, M0t90, BI, G150, dia0, Mt0, Lbexp, Lbtran, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S390" upshifts 1088479 /Source="Nicolas_upshifts" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="upshifts" CDS 1088595..1089623 /gene="iolX" /locus_tag="BSU_10850" /old_locus_tag="BSU10850" /EC_number="1.1.1.370" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11160890, 20133360, 23109554, 23504016, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160890, 20133360, 23109554, 23504016, 28693424; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol 2-dehydrogenase (NAD(+))" /protein_id="NP_388965.1" /db_xref="EnsemblGenomes-Gn:BSU10850" /db_xref="EnsemblGenomes-Tr:CAB12924" /db_xref="GOA:P40332" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11065" /db_xref="UniProtKB/Swiss-Prot:P40332" /translation="MEHQVRCAVLGLGRLGYYHAKNLVTSVPGAKLVCVGDPLKGRAE QVARELGIEKWSEDPYEVLEDPGIDAVIIVTPTSTHGDMIIKAAENGKQIFVEKPLTL SLEESKAASEKVKETGVICQVGFMRRFDPAYADAKRRIDAGEIGKPIYYKGFTRDQGA PPAEFIKHSGGIFIDCSIHDYDIARYLLGAEITSVSGHGRILNNPFMEQYGDVDQALT YIEFDSGAAGDVEASRTSPYGHDIRAEVIGTEGSIFIGTLRHQHVTILSAKGSSFDII PDFQTRFHEAYCLELQHFAECVRNGKTPIVTDIDATINLEVGIAATNSFRNGMPVQLD VKRAYTGM*" /label="iolX CDS" gene 1088595..1089623 /gene="iolX" /locus_tag="BSU_10850" /old_locus_tag="BSU10850" /label="iolX gene" downshifts 1089645 /Source="Nicolas_upshifts" /id="D589" /incds=0 /nref=4 /ntot=37 /MaxReadThrough="0.33001" /MaxDrop="3.45406" /score="8.69111487" /energy="-13.4" /TU="NA" /idTUdmin="U875" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1089674..1090183) /gene="yisT" /locus_tag="BSU_10860" /old_locus_tag="BSU10860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25651892; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative enzyme regulator of activity" /protein_id="NP_388966.2" /db_xref="EnsemblGenomes-Gn:BSU10860" /db_xref="EnsemblGenomes-Tr:CAB12925" /db_xref="GOA:O07939" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG12243" /db_xref="UniProtKB/Swiss-Prot:O07939" /translation="MTDAKQFYDYHSWANKKIFTHIENLPEETAYQEVKSVFPSVSDV LLHMCRADYIWLNVLSGVAYQEIIDSAGKLQSAQGNMAAIKQHAAELESQYHDFFSRQ TDLEQTFTMQHPKLGTLESTYADTILHVVNHGTYHRGNVTAMLRQLDHSGVPTDYMYY LYEKRESKG*" /label="yisT CDS" gene complement(1089674..1090183) /gene="yisT" /locus_tag="BSU_10860" /old_locus_tag="BSU10860" /label="yisT gene" downshifts complement(1089693) /Source="Nicolas_upshifts" /id="D590" /incds=0 /nref=81 /ntot=251 /MaxReadThrough="-0.0416600000000003" /MaxDrop="7.15629" /score="27.2292301" /energy="-13.4" /TU="NA" /idTUdmin="U876" /TUdmin="-16" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1090196..1090214) /Source="Nicolas_upshift_promotors" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1090212) /Source="Nicolas_upshifts" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1090226..1090234) /Source="Nicolas_upshift_promotors" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1090233..1090895) /gene="yisU" /locus_tag="BSU_10870" /old_locus_tag="BSU10870" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid related metabolite efflux transporter" /protein_id="NP_388967.1" /db_xref="EnsemblGenomes-Gn:BSU10870" /db_xref="EnsemblGenomes-Tr:CAB12926" /db_xref="GOA:O06730" /db_xref="InterPro:IPR001123" /db_xref="SubtiList:BG13100" /db_xref="UniProtKB/Swiss-Prot:O06730" /translation="MTISLMIEKKCERSFFSMNAIIHGIVLAFGLILPLGVQNVFIFQ QGALQKHIWRALPAVISASVCDTLLIVLAVAGVSVIVQELPVFETVMMAGGFLFLLYM GWVTWNIRPNTSQNEKHTFTPKKQAAFAAAVSLLNPHAILDTIGVIGTSSLQYSGLEK WLFMAACIAVSWIWFISLAIAGRLFQTIDTSGRLMLIVNKCSAAVMWAAAGYFGVSLF CN*" /label="yisU CDS" gene complement(1090233..1090895) /gene="yisU" /locus_tag="BSU_10870" /old_locus_tag="BSU10870" /label="yisU gene" promotor_-35 1090914..1090920 /Source="Nicolas_upshift_promotors" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1090934..1090953 /Source="Nicolas_upshift_promotors" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1090943 /Source="Nicolas_upshifts" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="upshifts" CDS 1090962..1092416 /gene="yisV" /locus_tag="BSU_10880" /old_locus_tag="BSU10880" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 19383706; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388968.2" /db_xref="EnsemblGenomes-Gn:BSU10880" /db_xref="EnsemblGenomes-Tr:CAB12927" /db_xref="GOA:Q796Q6" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13101" /db_xref="UniProtKB/Swiss-Prot:Q796Q6" /translation="MTLSQWQPSRKSDVPLHRQIEQYMKDKILHGEWAVGTKIPSQRT LADMFQVNRSTVTAAIDELTSQGLLEGRKGGGTKVVNSTWSVLTAEPPLDWSDYVRSG IHRANSSIIQAINQNEPRADIIRLGTGELSPDLVPADTIGRMFQQINPGVLSLGYEQP KGNRQLREAVADHLKGKKIHVSPSAILIVSGALQALQLISIGLLKRDSVILTEKPSYL QSLHVFQSAGMRLRGLPMDDEGVKAGLVSSNRKQYGGQLLYTIPSFHNPTGTVMSEQR RKEIISLSKKEQMPIIEDDAYGDLWFEEKPPQPLKAMDHEGNILYLGAFSKTVSPGLR IGWLAGPEPVIERLADIKMQTDYGSSGLSQWAAAEWLSQGYYEEHLTWVRRKLKERRD AAVHFLERYAGDIATWRIPAGGFYIWVTFHKNLPVSRFFYELLKRQVLVNPGYIYDGE DRNSIRLSYSYASLGDLETGIKAAAETARRLMMS*" /label="yisV CDS" gene 1090962..1092416 /gene="yisV" /locus_tag="BSU_10880" /old_locus_tag="BSU10880" /label="yisV gene" S_feature complement(1092271..1092423) /Source="Nicolas_S_feature" /locus_tag="new_1168046_1168198_c" /HighExp="Diami, Sw, C90, LBGstat, dia15, Paraq, dia5, BC, M40t45, Oxctl" /AntisenseName="yisV" /AntisenseCor="0.69858995161852" /AntisenseRegPval="-40" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S391" downshifts complement(1092306) /Source="Nicolas_upshifts" /id="D591" /incds=1 /nref=2 /ntot=84 /MaxReadThrough="2.36735" /MaxDrop="2.81041" /score="-5.131548" /energy="-17.3" /TU="NA" /idTUdmin="U879" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(1092424..1093062) /gene="yisX" /locus_tag="BSU_10890" /old_locus_tag="BSU10890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388970.1" /db_xref="EnsemblGenomes-Gn:BSU10890" /db_xref="EnsemblGenomes-Tr:CAB12929" /db_xref="InterPro:IPR001646" /db_xref="SubtiList:BG13103" /db_xref="UniProtKB/Swiss-Prot:O06733" /translation="MNKIAIQKPNIPENLQTADFHDAVTQDDVISMHLFEDCTICGED IERLCVEKTVFRNVVFIDVSFRHIELTDVIFEKCDLSNADFSGAVIHRTSVKQSKMVG MNVAEATLRNVSFEECHGHFSSFSYSNMKQVRFDHCALMQSECSDTVLQQTHFDGCEL EGASFTGTSLQNMDISTCRFEQLHVSLDKLKGCKIAPEHAIAFARALGAVIV*" /label="yisX CDS" gene complement(1092424..1093062) /gene="yisX" /locus_tag="BSU_10890" /old_locus_tag="BSU10890" /label="yisX gene" S_feature complement(1093063..1093197) /Source="Nicolas_S_feature" /locus_tag="new_1168838_1168972_c" /HighExp="Diami, dia15, dia5, C90, BC, Paraq, LBGstat, Lbtran, HiOs, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S392" promotor_-35 1093111..1093116 /Source="Nicolas_upshift_promotors" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1093132..1093150 /Source="Nicolas_upshift_promotors" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1093133 /Source="Nicolas_upshifts" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="upshifts" S_feature 1093143..1093267 /Source="Nicolas_S_feature" /locus_tag="new_1168918_1169042" /HighExp="S6, S5, S8, S7, S4, BT, B36, S3, G/S, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S393" promotor_-10 complement(1093183..1093202) /Source="Nicolas_upshift_promotors" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1093197) /Source="Nicolas_upshifts" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1093217..1093224) /Source="Nicolas_upshift_promotors" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1093268..1094074 /gene="yisY" /locus_tag="BSU_10900" /old_locus_tag="BSU10900" /EC_number="3.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl hydrolase or peroxidase" /protein_id="NP_388971.1" /db_xref="EnsemblGenomes-Gn:BSU10900" /db_xref="EnsemblGenomes-Tr:CAB12930" /db_xref="GOA:O06734" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13104" /db_xref="UniProtKB/Swiss-Prot:O06734" /translation="MGHYIKTEEHVTLFVEDIGHGRPIIFLHGWPLNHKMFEYQMNEL PKRGFRFIGVDLRGYGQSDRPWEGYDYDTMADDVKAVIYTLQLENAILAGFSMGGAIA IRYMARHEGADVDKLILLSAAAPAFTKRPGYPYGMRKQDIDDMIELFKADRPKTLADL GKQFFEKKVSPELRQWFLNLMLEASSYGTIHSGIALRDEDLRKELAAIKVPTLILHGR KDRIAPFDFAKELKRGIKQSELVPFANSGHGAFYEEKEKINSLIAQFSNS*" /label="yisY CDS" gene 1093268..1094074 /gene="yisY" /locus_tag="BSU_10900" /old_locus_tag="BSU10900" /label="yisY gene" downshifts 1094067 /Source="Nicolas_upshifts" /id="D592" /incds=0 /nref=4 /ntot=24 /MaxReadThrough="2.64682" /MaxDrop="5.60718" /score="8.70914085" /energy="-6.5" /TU="NA" /idTUdmin="U878" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1094102..1094701) /gene="yisZ" /locus_tag="BSU_10910" /old_locus_tag="BSU10910" /EC_number="2.7.1.25" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative adenylylsulfate kinase" /protein_id="NP_388972.1" /db_xref="EnsemblGenomes-Gn:BSU10910" /db_xref="EnsemblGenomes-Tr:CAB12931" /db_xref="GOA:O06735" /db_xref="InterPro:IPR002891" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13105" /db_xref="UniProtKB/Swiss-Prot:O06735" /translation="MTHNPNIIWHPAAISKSDRQSLNGHKSCVLWFTGLSGSGKSVLA NAVDEKLYRKGIQSYVLDGDNIRHGLNKDLGFQTGDRIENIRRIGEVAKLFVDSGQMI LTAFISPFREDRDMVRALFPKGEFFEIYVKCPLHVCEQRDPKGLYKKARNGEIKHFTG IDSPYEAPLSPDFIIESDQTSISDGADLIINALQNRGII*" /label="yisZ CDS" gene complement(1094102..1094701) /gene="yisZ" /locus_tag="BSU_10910" /old_locus_tag="BSU10910" /label="yisZ gene" downshifts complement(1094121) /Source="Nicolas_upshifts" /id="D593" /incds=0 /nref=35 /ntot=44 /MaxReadThrough="1.69999" /MaxDrop="6.8011" /score="17.1506785" /energy="-7.3" /TU="NA" /idTUdmin="U880" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1094698..1095867) /gene="yitA" /locus_tag="BSU_10920" /old_locus_tag="BSU10920" /EC_number="2.7.7.4" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfate adenylyltransferase" /protein_id="NP_388973.2" /db_xref="EnsemblGenomes-Gn:BSU10920" /db_xref="EnsemblGenomes-Tr:CAB12932" /db_xref="GOA:O06736" /db_xref="InterPro:IPR002650" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020792" /db_xref="InterPro:IPR024951" /db_xref="InterPro:IPR025980" /db_xref="SubtiList:BG13106" /db_xref="UniProtKB/Swiss-Prot:O06736" /translation="MNGNEPHGGVLINRCDPACHFEGCACQAELDQLALSDLELIAIG GYSPLTGFLGEKDYHSVVKEMRLANGLPWSLPITLPVGEKTARQLSAGDHVKLVKDGV TYGMITVTDIYQPDKTQEALSVFKTNDPAHPGVKKLLARPDYYIGGPITVSSLPDKSF EQFYATPAETRAAFQKLGWKTIVGFQTRNPVHRAHEYIQKTALETVDGLLLHPLVGET KSDDIPSDIRMESYQALLNHYYPKDRVMLSVFPAAMRYAGPREAIFHALVRKNYGCTH FIVGRDHAGVGSYYGTYDAQNIFQSFTEEELGIKPLFFEHSFYCRKCGNMGTSKTCPH SPRDHIHLSGTKVRELLRQGKKPPKEFSRPEVAAVLIKGLHQQPVAIKQNSGELQ*" /label="yitA CDS" gene complement(1094698..1095867) /gene="yitA" /locus_tag="BSU_10920" /old_locus_tag="BSU10920" /label="yitA gene" S_feature complement(1095868..1095979) /Source="Nicolas_S_feature" /locus_tag="new_1171643_1171754_c" /HighExp="S6, S7, S8, BT, S5, B36, G/S, Pyr, SMMPr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S394" CDS complement(1095980..1096690) /gene="yitB" /locus_tag="BSU_10930" /old_locus_tag="BSU10930" /EC_number="1.8.4.8" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phospho-adenylylsulfate reductase" /protein_id="NP_388974.2" /db_xref="EnsemblGenomes-Gn:BSU10930" /db_xref="EnsemblGenomes-Tr:CAB12933" /db_xref="GOA:O06737" /db_xref="InterPro:IPR002500" /db_xref="InterPro:IPR004511" /db_xref="InterPro:IPR011798" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13107" /db_xref="UniProtKB/Swiss-Prot:O06737" /translation="MNETITYDTWNDMLSKQITDQLIDELDVLKWAYRTYGEKIVYAC SFGAEGMVLLDLISKINKNAHIIFLDTGLHFQETYELIETVKERYPGFAIQMLEPELS LTEQGTKYGGELWKHNPNLCCQLRKIEPLKKHLSGMTAWISGLRRDQSPTRKHIQYVN LDQKFELIKICPLIHWTWDDVWTYIRLHNLPYNKLHDQHYPSIGCEMCTLPSPDPNDE RAGRWAGREKTECGLHQE*" /label="yitB CDS" gene complement(1095980..1096690) /gene="yitB" /locus_tag="BSU_10930" /old_locus_tag="BSU10930" /label="yitB gene" promotor_-10 complement(1096734..1096753) /Source="Nicolas_upshift_promotors" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1096756) /Source="Nicolas_upshifts" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1096766..1096775) /Source="Nicolas_upshift_promotors" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1096805..1096814 /Source="Nicolas_upshift_promotors" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1096828..1096847 /Source="Nicolas_upshift_promotors" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1096839 /Source="Nicolas_upshifts" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="upshifts" CDS 1096875..1097561 /gene="slpH" /locus_tag="BSU_10940" /old_locus_tag="BSU10940" /EC_number="3.1.3.71" /function="15.7: Sporulation and germination" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 3346220, 11830598, 15383836, 16341843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-phospho,3-sulfolactate phosphatase (sporulation related)" /protein_id="NP_388975.1" /db_xref="EnsemblGenomes-Gn:BSU10940" /db_xref="EnsemblGenomes-Tr:CAB12934" /db_xref="GOA:O06738" /db_xref="InterPro:IPR005238" /db_xref="InterPro:IPR036702" /db_xref="SubtiList:BG13108" /db_xref="UniProtKB/Swiss-Prot:O06738" /translation="MPIAIYQGHHHSLAPADINIVIDVIRAFTVAHYAFIGGAKEILL VRTADEAFALKDTYPDYVLTGEEKGVGISGFDLDNSPKRMAGQNMTDKSLIQKTTNGV TAALGALNAKHLFVTGFSNAKTTAQHVKKLVANDCVINIVASHPSGDDDMACAEYIKG IIEGTNVVTAAEAIERIKGSSVAEKFFDCRQPLFDSEDIVYCTKELTGDFVMKVKQDG EVPTIERVII*" /label="slpH CDS" gene 1096875..1097561 /gene="slpH" /locus_tag="BSU_10940" /old_locus_tag="BSU10940" /label="slpH gene" CDS 1097558..1098316 /gene="slpS" /locus_tag="BSU_10950" /old_locus_tag="BSU10950" /EC_number="4.4.1.19" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11830598, 15014443, 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-phospho-3-sulfolactate synthase" /protein_id="NP_388976.1" /db_xref="EnsemblGenomes-Gn:BSU10950" /db_xref="EnsemblGenomes-Tr:CAB12935" /db_xref="GOA:O06739" /db_xref="InterPro:IPR003830" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036112" /db_xref="PDB:1U83" /db_xref="SubtiList:BG13109" /db_xref="UniProtKB/Swiss-Prot:O06739" /translation="MNDFSLELPVRTNKPRETGQSILIDNGYPLQFFKDAIAGASDYI DFVKFGWGTSLLTKDLEEKISTLKEHDITFFFGGTLFEKYVSQKKVNEFHRYCTYFGC EYIEISNGTLPMTNKEKAAYIADFSDEFLVLSEVGSKDAELASRQSSEEWLEYIVEDM EAGAEKVITEARESGTGGICSSSGDVRFQIVDDIISSDIDINRLIFEAPNKTLQQGFI QKIGPNVNLANIPFHDAIALETLRLGLRSDTFFL*" /label="slpS CDS" gene 1097558..1098316 /gene="slpS" /locus_tag="BSU_10950" /old_locus_tag="BSU10950" /label="slpS gene" downshifts 1098313 /Source="Nicolas_upshifts" /id="D594" /incds=0 /nref=2 /ntot=20 /MaxReadThrough="2.37654" /MaxDrop="4.17689" /score="-1.32868938" /energy="-17.6" /TU="NA" /idTUdmin="U881" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1098361..1098990) /gene="yitE" /locus_tag="BSU_10960" /old_locus_tag="BSU10960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26335199; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388977.1" /db_xref="EnsemblGenomes-Gn:BSU10960" /db_xref="EnsemblGenomes-Tr:CAB12936" /db_xref="GOA:O06740" /db_xref="InterPro:IPR003740" /db_xref="SubtiList:BG13110" /db_xref="UniProtKB/Swiss-Prot:O06740" /translation="MAELLMKAKLTFMIVVGGVLQGLGMSLFLFPHDIPTGGAAGIAV LLHYLFQIPHGFSVWAVNVSMLFTALKWLEMRTFTGTLASITVTSVSVLIFDAVFPDI TSNLWLDLASGAVLLGLGIGLLYKYKISNGGFGALALMISIYRGGNPGTILLIMNCII FMVTASIIDWGIVIQALICQVISTRVIDFIYNIRLTSLPYLTPMYRHKK*" /label="yitE CDS" gene complement(1098361..1098990) /gene="yitE" /locus_tag="BSU_10960" /old_locus_tag="BSU10960" /label="yitE gene" promotor_-10 complement(1099024..1099042) /Source="Nicolas_upshift_promotors" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1099041) /Source="Nicolas_upshifts" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1099057..1099062) /Source="Nicolas_upshift_promotors" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1099086..1100201) /gene="yitF" /locus_tag="BSU_10970" /old_locus_tag="BSU10970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 11747447, 27994575; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enolase superfamily enzyme (isomerase /dehydratase)" /protein_id="NP_388978.1" /db_xref="EnsemblGenomes-Gn:BSU10970" /db_xref="EnsemblGenomes-Tr:CAB12937" /db_xref="GOA:O06741" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR036849" /db_xref="PDB:2GDQ" /db_xref="PDB:2GGE" /db_xref="SubtiList:BG13111" /db_xref="UniProtKB/Swiss-Prot:O06741" /translation="MKIVRIETFPLFHRLEKPYGDANGFKRYRTCYLIRIITESGIDG WGECVDWLPALHVGFTKRIIPFLLGKQAGSRLSLVRTIQKWHQRAASAVSMALTEIAA KAADCSVCELWGGRYREEIPVYASFQSYSDSPQWISRSVSNVEAQLKKGFEQIKVKIG GTSFKEDVRHINALQHTAGSSITMILDANQSYDAAAAFKWERYFSEWTNIGWLEEPLP FDQPQDYAMLRSRLSVPVAGGENMKGPAQYVPLLSQRCLDIIQPDVMHVNGIDEFRDC LQLARYFGVRASAHAYDGSLSRLYALFAQACLPPWSKMKNDHIEPIEWDVMENPFTDL VSLQPSKGMVHIPKGKGIGTEINMEIVNRYKWDGSAY*" /label="yitF CDS" gene complement(1099086..1100201) /gene="yitF" /locus_tag="BSU_10970" /old_locus_tag="BSU10970" /label="yitF gene" downshifts complement(1099115) /Source="Nicolas_upshifts" /id="D595" /incds=0 /nref=11 /ntot=42 /MaxReadThrough="1.81817" /MaxDrop="4.27426" /score="13.5713023" /energy="-14.5" /TU="NA" /idTUdmin="U883" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1100210..1101478) /gene="yitG" /locus_tag="BSU_10980" /old_locus_tag="BSU10980" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 14762009, 15109717, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388979.1" /db_xref="EnsemblGenomes-Gn:BSU10980" /db_xref="EnsemblGenomes-Tr:CAB12938" /db_xref="GOA:Q796Q1" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13112" /db_xref="UniProtKB/Swiss-Prot:Q796Q1" /translation="MESSKQNNGMTIVAIGSIPLILTLGNSMLIPILPKMKSELHLSQ FQVSLVITVFSLIAAFAIPIVGYLADRFSRKVIIIPCLILYGAGGLLAGFAAGFFDNA YPWVMAGRALQGIGAAGTGPIAMALTGDLFKGAQESKVLGLVEASNGMGKVLSPIIGS LIALLVWYGAFFAFPVFCIISIVLTWIFIKEKKKEKEPPPIGQYAKGLLSVFKHEGRW LFTAYLAGATCLFTLFGILFYLSDVLEKTYDTDGVKKGLILAIPLLVMCVTSYTTGSK IGQKQSLMKKLIVLGLAFMTVSYAALSFIENLVLFISVLVLSSIGSGLVLPCVNSFIT GAVGKERRGFVTSLYGSVRFLGVAIGPPIFGRLMQWSRPGMFLSIAGLTLVVGILVMM LIHVKQNNEETKEKEDPKMAGNRLQPAEER*" /label="yitG CDS" gene complement(1100210..1101478) /gene="yitG" /locus_tag="BSU_10980" /old_locus_tag="BSU10980" /label="yitG gene" promotor_-10 complement(1101504..1101515) /Source="Nicolas_upshift_promotors" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1101513) /Source="Nicolas_upshifts" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1101529..1101535) /Source="Nicolas_upshift_promotors" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1101590..1102438) /gene="yitH" /locus_tag="BSU_10990" /old_locus_tag="BSU10990" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388980.1" /db_xref="EnsemblGenomes-Gn:BSU10990" /db_xref="EnsemblGenomes-Tr:CAB12939" /db_xref="GOA:O06743" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13113" /db_xref="UniProtKB/Swiss-Prot:O06743" /translation="MDVVDELIKLHEEHVSGLLRLCGQAGWPDYGEQELKLLVQQGRF FGYQNVSGDIISCIGLFLFGRLTSIGLVIVDKEYQRLGLGRRMVNACITQTDENTAIR LCATKEGLPLYEKAGFHTAGSVRKYSCHSFQPYTKKLDAELTSFREQDFHDLTAADLA AFGGDRSNLLQQLISASCECIIARNQDGQLIGYGLSVQTPANLKFGPIIAPSSDVAAQ IITRLAAGKQGPMRIDIPSEHTSLHDSLIEMGFHKDDEPPILFYQKKAPIQNGHLYAL ISQALG*" /label="yitH CDS" gene complement(1101590..1102438) /gene="yitH" /locus_tag="BSU_10990" /old_locus_tag="BSU10990" /label="yitH gene" downshifts complement(1101601) /Source="Nicolas_upshifts" /id="D596" /incds=0 /nref=34 /ntot=209 /MaxReadThrough="2.34135" /MaxDrop="3.51892" /score="14.8688564" /energy="-11.7" /TU="NA" /idTUdmin="U884" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1102443..1102892) /gene="yitI" /locus_tag="BSU_11000" /old_locus_tag="BSU11000" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388981.2" /db_xref="EnsemblGenomes-Gn:BSU11000" /db_xref="EnsemblGenomes-Tr:CAB12940" /db_xref="GOA:O06744" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13114" /db_xref="UniProtKB/Swiss-Prot:O06744" /translation="MLEVKTISVEDTYEIRHRILRPHQSIEQCKYKEDHAEGSFHLGV FYDGTLISIASFSPQSQPLLTEASAYRLRGMATLEGYRDQKAGSTLIKHAEHKLAESG VQAVWCNARHHVKGYYAKLGWKELGEPFDIPGIGNHIVMYKTLRTSR*" /label="yitI CDS" gene complement(1102443..1102892) /gene="yitI" /locus_tag="BSU_11000" /old_locus_tag="BSU11000" /label="yitI gene" promotor_-10 complement(1102913..1102932) /Source="Nicolas_upshift_promotors" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1102927) /Source="Nicolas_upshifts" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1102948..1102949) /Source="Nicolas_upshift_promotors" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1102982..1104820) /gene="samT" /locus_tag="BSU_11010" /old_locus_tag="BSU11010" /EC_number="1.5.1.20" /EC_number="2.1.1.10" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094622, 17264075, 20421295, 20951706, 26233166; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional homocysteine S-methyltransferase using (R,S)AdoMet and methylenetetrahydrofolate reductase [NAD(P)H]" /protein_id="NP_388982.1" /db_xref="EnsemblGenomes-Gn:BSU11010" /db_xref="EnsemblGenomes-Tr:CAB12941" /db_xref="GOA:O06745" /db_xref="InterPro:IPR003171" /db_xref="InterPro:IPR003726" /db_xref="InterPro:IPR029041" /db_xref="InterPro:IPR036589" /db_xref="SubtiList:BG13115" /db_xref="UniProtKB/Swiss-Prot:O06745" /translation="MGLLEDLQRQVLIGDGAMGTLLYSYGIDRCFEELNISKPEEIQR IHKAYVEAGANIIQTNTYGANYIKLSRHGLEDDIKKMNQEAVKIARASAGDAYVLGTM GGIRTFNKNAYSLDEIKRSFREQLYLLLHEEPDGLLLETYYDLEEAREVLKIARKETD LPIMLNVSMHEQGVLQDGTPLSDALRSIADLGADIVGINCRLGPYHMIEALSEVPIFD DVFLSVYPNSSLPSLEEGRLVYETDDTYFQNSASEFRKQGARIIGGCCGTTPNHIRAM AEAVGGLAPITEKEVKTRAKEFISVHHERTEPGLDEIAAKKRSIIVELDPPKKLSFDK FLSAAAELKEAGIDALTLADNSLATPRISNVACGALVKQQLDMRSLVHITCRDRNIIG LQSHLMGLDTLGLNDVLAITGDPSKIGDFPGATSVYDLTSFDLIRLIKQFNEGLSLSG KPLGKKTNFSVAAAFNPNVRHLDKAVKRLEKKIDCGADYFVSQPVYSEQQLVDIHNET KHLKTPIYIGIMPLTSSRNAEFIHNEIPGIKLSDTIREKMAHAGEDKEKQKAEGLAIA RSLLDTACELFNGIYLITPFLRSDLTAELTSYIQQKDEQRQNIFLH*" /label="samT CDS" gene complement(1102982..1104820) /gene="samT" /locus_tag="BSU_11010" /old_locus_tag="BSU11010" /label="samT gene" downshifts complement(1103009) /Source="Nicolas_upshifts" /id="D597" /incds=0 /nref=14 /ntot=91 /MaxReadThrough="3.04289" /MaxDrop="4.13744" /score="12.9586126" /energy="-16.2" /TU="U885" /idTUdmin="U885" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts complement(1104902) /Source="Nicolas_upshifts" /id="D598" /incds=0 /nref=47 /ntot=128 /MaxReadThrough="8.00128" /MaxDrop="5.61487" /score="22.3754155" /energy="-7.3" /TU="U885,U887" /idTUdmin="U887" /TUdmin="-1079" /isTUend="FALSE" /label="downshifts" misc_RNA complement(1104910..1105027) /gene="mswK" /locus_tag="BSU_misc_RNA_12" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswK RNA" gene complement(1104910..1105027) /gene="mswK" /locus_tag="BSU_misc_RNA_12" /label="mswK gene" promotor_-10 complement(1105079..1105098) /Source="Nicolas_upshift_promotors" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="promotor_-10" upshifts complement(1105093) /Source="Nicolas_upshifts" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="upshifts" promotor_-35 complement(1105113..1105120) /Source="Nicolas_upshift_promotors" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="promotor_-35" CDS complement(1105134..1105625) /gene="yitK" /locus_tag="BSU_11020" /old_locus_tag="BSU11020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12943362, 25329577; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA or cyclic d-GMP binding protein" /protein_id="NP_388983.1" /db_xref="EnsemblGenomes-Gn:BSU11020" /db_xref="EnsemblGenomes-Tr:CAB12942" /db_xref="InterPro:IPR007551" /db_xref="InterPro:IPR035570" /db_xref="InterPro:IPR035571" /db_xref="InterPro:IPR036183" /db_xref="SubtiList:BG13116" /db_xref="UniProtKB/Swiss-Prot:O06746" /translation="MAKESSFDIVSKVELPEVQNAIQIALKEISTRYDFKGSKSDISL DKEELVLVSDDEFKLSQLKDVLVSKLIKRNVPTKNIDYGKVENASGGTVRQRAKLVQG IDKDNAKKINTIIKNSGLKVKSQVQDDQVRVTGKNKDDLQQIISAVRGADLPIDVQFI NFR*" /label="yitK CDS" gene complement(1105134..1105625) /gene="yitK" /locus_tag="BSU_11020" /old_locus_tag="BSU11020" /label="yitK gene" promotor_-35 1105643..1105646 /Source="Nicolas_upshift_promotors" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1105649..1105668) /Source="Nicolas_upshift_promotors" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="promotor_-10" promotor_-10 1105661..1105680 /Source="Nicolas_upshift_promotors" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1105662 /Source="Nicolas_upshifts" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1105667) /Source="Nicolas_upshifts" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="upshifts" promotor_-35 complement(1105683..1105690) /Source="Nicolas_upshift_promotors" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="promotor_-35" CDS 1105724..1106620 /gene="yitL" /locus_tag="BSU_11030" /old_locus_tag="BSU11030" /function="9.4: RNA processing" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 20399190; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA-binding protein" /protein_id="NP_388984.1" /db_xref="EnsemblGenomes-Gn:BSU11030" /db_xref="EnsemblGenomes-Tr:CAB12943" /db_xref="GOA:O06747" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014464" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13117" /db_xref="UniProtKB/Swiss-Prot:O06747" /translation="MLTKSAENKRNRKDDSMRPGQQLTLSIDHQTDFGYFLTDGEDTI LLHNSEMTEDIEDRDEVEVFIYVDQQERLAATMKIPIISADEYGWVEVVDKVEDMGVF VDVGLSKDALVATEHLPPYEDVWPQKGDKLYCMLKVTNRGRMFAKPAPEDIISELFTD ASEDLMNKELTGTVYRLIASGSFVITDDGIRCFIHPSERKEEPRLGSRVTGRVIQVKE DGSVNLSLLPRKQDAMSVDAECILTYMRMRNGAMPYSDKSQPDDIRERFNMSKAAFKR ALGHLMKNGKVYQENGWTYEKK*" /label="yitL CDS" gene 1105724..1106620 /gene="yitL" /locus_tag="BSU_11030" /old_locus_tag="BSU11030" /label="yitL gene" downshifts 1106607 /Source="Nicolas_upshifts" /id="D599" /incds=0 /nref=232 /ntot=261 /MaxReadThrough="1.78082" /MaxDrop="6.73614" /score="40.361011" /energy="-21.5" /TU="NA" /idTUdmin="U886" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1106673..1107257) /gene="yitM" /locus_tag="BSU_11040" /old_locus_tag="BSU11040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11557812" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388985.1" /db_xref="EnsemblGenomes-Gn:BSU11040" /db_xref="EnsemblGenomes-Tr:CAB12944" /db_xref="GOA:O06748" /db_xref="InterPro:IPR023888" /db_xref="SubtiList:BG13118" /db_xref="UniProtKB/Swiss-Prot:O06748" /translation="MKKAFLVFLSVVLVTTVFLVKQQESVAQAKQLEYSGEEIFKGFV FAQGEVGKQLPEVFNKAMTDKLNTKQAKAFANQVVADIKKEDADFFDNLKKAVYSKDA LKVDELLKKAGQIVEEKVEAAKEIAASKDDTSRVQAELVNTVDTANYFYYVSYVAAAG ALILIILAIDITPIAISDNVDREMAIRTLVDELN*" /label="yitM CDS" gene complement(1106673..1107257) /gene="yitM" /locus_tag="BSU_11040" /old_locus_tag="BSU11040" /label="yitM gene" downshifts complement(1106683) /Source="Nicolas_upshifts" /id="D600" /incds=0 /nref=68 /ntot=158 /MaxReadThrough="1.3386" /MaxDrop="7.40935" /score="10.143892" /energy="-21.5" /TU="NA" /idTUdmin="U888" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1107254..1108183) /gene="yitO" /locus_tag="BSU_11055" /old_locus_tag="BSU11055" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11557812, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein with HTTM domain" /protein_id="NP_388987.2" /db_xref="EnsemblGenomes-Gn:BSU11055" /db_xref="EnsemblGenomes-Tr:CAB12946" /db_xref="GOA:O06750" /db_xref="InterPro:IPR011020" /db_xref="InterPro:IPR023894" /db_xref="SubtiList:BG13120" /db_xref="UniProtKB/Swiss-Prot:O06750" /translation="MLENIKQTITRWDERNPWTNVYGLARSIIALSSLLTLLINHPSL IMKPASGISSYPACKMNLSLFCLGENNYMMLNLFRWVCIAILVLVVIGWRPRITGVLH WYVSYSLQSSLIVIDGGEQAAAVMTFLLLPITLTDPRKWHWSTRPIEGKRTLGKITAF ISYFVIRIQVAVLYFHSTVAKLSQQEWVDGTAVYYFAQEKTIGFNGFFQALTKPIVTS PFVVIPTWGTLLVQIVIFAALFAPKKHWRLILIIAVFMHEIFAVMLGLISFSIIMAGI LILYLTPIDSTIQFTYIRRLLWNKKHKKGEVSV*" /label="yitO CDS" gene complement(1107254..1108183) /gene="yitO" /locus_tag="BSU_11055" /old_locus_tag="BSU11055" /label="yitO gene" upshifts complement(1107341) /Source="Nicolas_upshifts" /id="U888" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.232767232767233" /psig="0.63936063936064" /xcortree=2974 /SigmaFactorBS="agtcatgctgggcctcatcagtttttcgattatcatggccgg cattttgatattgtatctcaCtcctatcgattccacgattcaatttacatatattcgc a" /listShort="yitM" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1108168..1108704) /gene="yitP" /locus_tag="BSU_11070" /old_locus_tag="BSU11070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 6289325, 11557812" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388988.1" /db_xref="EnsemblGenomes-Gn:BSU11070" /db_xref="EnsemblGenomes-Tr:CAB12947" /db_xref="GOA:O06751" /db_xref="InterPro:IPR023902" /db_xref="SubtiList:BG13121" /db_xref="UniProtKB/Swiss-Prot:O06751" /translation="MQKSISFFVIFSILWGSLFLFSIIGSLGTTPIPLTKDSKFLMSS ILPQGWGFFSKNPRDTAIGLYEAENASAKVRWPNMRADNLFGLYRYGRSQGVEMGVIY SQVGKEQWTACKEKDLGACKSKAKTVQLKTPAPRPLLCGSYYLTKEDIVPWSYSKYTP SSYQVKSIVKVVISCSKT*" /label="yitP CDS" gene complement(1108168..1108704) /gene="yitP" /locus_tag="BSU_11070" /old_locus_tag="BSU11070" /label="yitP gene" promotor_-10 complement(1108740..1108759) /Source="Nicolas_upshift_promotors" /id="U889" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.71028971028971" /psig="0.988011988011988" /xcortree=2975 /SigmaFactorBS="ccttttaacaaaaatggaatttctcatactttttaacCTTTt tattacataaatgTTTTTATATTATGAAAAGTGtaaaaacgattcttcaggttaaaag g" /listShort="yitP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1108754) /Source="Nicolas_upshifts" /id="U889" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.71028971028971" /psig="0.988011988011988" /xcortree=2975 /SigmaFactorBS="ccttttaacaaaaatggaatttctcatactttttaacCTTTt tattacataaatgTTTTTATATTATGAAAAGTGtaaaaacgattcttcaggttaaaag g" /listShort="yitP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1108774..1108777) /Source="Nicolas_upshift_promotors" /id="U889" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.71028971028971" /psig="0.988011988011988" /xcortree=2975 /SigmaFactorBS="ccttttaacaaaaatggaatttctcatactttttaacCTTTt tattacataaatgTTTTTATATTATGAAAAGTGtaaaaacgattcttcaggttaaaag g" /listShort="yitP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1108845..1108852 /Source="Nicolas_upshift_promotors" /id="U890" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=3150 /SigmaFactorBS="aaaggaaaaacaggacattttacactgctatatgtGATTGAT AtatagtgtttttttCGATATATTTAAACCATGAAaacgaatcaagttaatgaccgct g" /listShort="yizB, yitQ, yitR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1108867..1108886 /Source="Nicolas_upshift_promotors" /id="U890" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=3150 /SigmaFactorBS="aaaggaaaaacaggacattttacactgctatatgtGATTGAT AtatagtgtttttttCGATATATTTAAACCATGAAaacgaatcaagttaatgaccgct g" /listShort="yizB, yitQ, yitR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1108870 /Source="Nicolas_upshifts" /id="U890" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=3150 /SigmaFactorBS="aaaggaaaaacaggacattttacactgctatatgtGATTGAT AtatagtgtttttttCGATATATTTAAACCATGAAaacgaatcaagttaatgaccgct g" /listShort="yizB, yitQ, yitR" /GFF_Attribute="listLong" /label="upshifts" CDS 1108882..1109229 /gene="yizB" /locus_tag="BSU_11079" /old_locus_tag="BSU11079" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="YP_003097701.1" /db_xref="EnsemblGenomes-Gn:BSU11079" /db_xref="EnsemblGenomes-Tr:CAX52589" /db_xref="GOA:C0H3Y4" /db_xref="InterPro:IPR005149" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3Y4" /translation="MKTNQVNDRWIVQFRKGIFELAILSLLRSKPMYGYELTSSLKTT SALAISEGAIYPILKRMTEKGWIEFFWEDSLDGPKRKYYKMTQKGEEMLKERLEKYLE THQALLSLSGDLL*" /label="yizB CDS" gene 1108882..1109229 /gene="yizB" /locus_tag="BSU_11079" /old_locus_tag="BSU11079" /label="yizB gene" CDS 1109226..1109813 /gene="yitQ" /locus_tag="BSU_11080" /old_locus_tag="BSU11080" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23504016" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388989.2" /db_xref="EnsemblGenomes-Gn:BSU11080" /db_xref="EnsemblGenomes-Tr:CAB12948" /db_xref="GOA:O06752" /db_xref="SubtiList:BG13122" /db_xref="UniProtKB/Swiss-Prot:O06752" /translation="MNGQLIIDRYMEELNAELANMPDVERENAIDELKGHITAFVQDR IKAGLSEEELQEAVESEFSHPKELAELMMGDGGETKRRRSLLGKSWISVLLIVTIIAL PLLPSDFRHLPLAVYLMVLAGYVWKRKKLVMFAGVRKNKMRSQKEIVKISRVGAVYLL FLAVVLLLSPFLNALVVLLLIAVSCAAFFLFLNIK*" /label="yitQ CDS" gene 1109226..1109813 /gene="yitQ" /locus_tag="BSU_11080" /old_locus_tag="BSU11080" /label="yitQ gene" CDS 1109833..1110126 /gene="yitR" /locus_tag="BSU_11090" /old_locus_tag="BSU11090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388990.1" /db_xref="EnsemblGenomes-Gn:BSU11090" /db_xref="EnsemblGenomes-Tr:CAB12949" /db_xref="GOA:O06753" /db_xref="InterPro:IPR017259" /db_xref="SubtiList:BG13123" /db_xref="UniProtKB/Swiss-Prot:O06753" /translation="MEISINYLLIVIALLFFVVAYFVGIKKQTWMLAGFNEARIRDKD RLARIAGYFFLNSGLFILLNSFISFQGQEQLIPPLILAYGAGVIIYVNKKLVE*" /label="yitR CDS" gene 1109833..1110126 /gene="yitR" /locus_tag="BSU_11090" /old_locus_tag="BSU11090" /label="yitR gene" downshifts 1110106 /Source="Nicolas_upshifts" /id="D601" /incds=0 /nref=119 /ntot=240 /MaxReadThrough="1.96008" /MaxDrop="5.72545" /score="2.11183863" /energy="-12.6" /TU="NA" /idTUdmin="U890" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1110150 /Source="Nicolas_upshifts" /id="D602" /incds=0 /nref=1 /ntot=15 /MaxReadThrough="0.34732" /MaxDrop="3.0285" /score="2.11183863" /energy="-12.6" /TU="NA" /idTUdmin="U890" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS 1110262..1111878 /gene="nprB" /locus_tag="BSU_11100" /old_locus_tag="BSU11100" /EC_number="3.4.24.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1917867, 16672610" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1917867, 16672610; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular neutral protease B" /protein_id="NP_388991.1" /db_xref="EnsemblGenomes-Gn:BSU11100" /db_xref="EnsemblGenomes-Tr:CAB12950" /db_xref="GOA:P39899" /db_xref="InterPro:IPR001570" /db_xref="InterPro:IPR011096" /db_xref="InterPro:IPR013856" /db_xref="InterPro:IPR023612" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG10691" /db_xref="UniProtKB/Swiss-Prot:P39899" /translation="MRNLTKTSLLLAGLCTAAQMVFVTHASAEESIEYDHTYQTPSYI IEKSPQKPVQNTTQKESLFSYLDKHQTQFKLKGNANSHFRVSKTIKDPKTKQTFFKLT EVYKGIPIYGFEQAVAMKENKQVKSFFGKVHPQIKDVSVTPSISEKKAIHTARRELEA SIGKIEYLDGEPKGELYIYPHDGEYDLAYLVRLSTSEPEPGYWHYFIDAKNGKVIESF NAIHEAAGTGIGVSGDEKSFDVTEQNGRFYLADETRGKGINTFDAKNLNETLFTLLSQ LIGYTGKEIVSGTSVFNEPAAVDAHANAQAVYDYYSKTFGRDSFDQNGARITSTVHVG KQWNNAAWNGVQMVYGDGDGSKFKPLSGSLDIVAHEITHAVTQYSAGLLYQGEPGALN ESISDIMGAMADRDDWEIGEDVYTPGIAGDSLRSLEDPSKQGNPDHYSNRYTGTEDYG GVHINSSIHNKAAYLLAEGGVHHGVQVEGIGREASEQIYYRALTYYVTASTDFSMMKQ AAIEAANDLYGEGSKQSASVEKAYEAVGIL*" /label="nprB CDS" gene 1110262..1111878 /gene="nprB" /locus_tag="BSU_11100" /old_locus_tag="BSU11100" /label="nprB gene" downshifts 1111866 /Source="Nicolas_upshifts" /id="D603" /incds=0 /nref=2 /ntot=55 /MaxReadThrough="0.278770000000001" /MaxDrop="3.08544" /score="2.81939887" /energy="-8.6" /TU="NA" /idTUdmin="U890" /TUdmin=1760 /isTUend="FALSE" /label="downshifts" CDS complement(1111925..1112776) /gene="fakBB" /locus_tag="BSU_11110" /old_locus_tag="BSU11110" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 25002480, 26774272, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid kinase fatty acid binding subunit B" /protein_id="NP_388992.1" /db_xref="EnsemblGenomes-Gn:BSU11110" /db_xref="EnsemblGenomes-Tr:CAB12951" /db_xref="GOA:P70945" /db_xref="InterPro:IPR003797" /db_xref="SubtiList:BG12244" /db_xref="UniProtKB/Swiss-Prot:P70945" /translation="MTVHLIADSATDLPRSYFEEKGIGFIPLRVSLGDKEFEDAVTIH ADQIFEAMQNGETPKTSQASPQTIKNVFLQYAETGDPALYIAFSSGLSGTYQTAVMIA NEVKEEFPDFDLRVIDSKCASLGYGLAVRHAADLCINGNTIQEIETSVKNFCSQLEHI FTVDDLTYLARGGRISKTSAFVGGLLNIKPLLQMEDGKLVPLEKIRGQKKLFKRIIEL MKERGDDWSNQTVGISYAANKEKATDMKHLIEEAFKPKEIIMHPISSAIGSHAGPGTL AIFFLRK*" /label="fakBB CDS" gene complement(1111925..1112776) /gene="fakBB" /locus_tag="BSU_11110" /old_locus_tag="BSU11110" /label="fakBB gene" downshifts complement(1111942) /Source="Nicolas_upshifts" /id="D604" /incds=0 /nref=209 /ntot=263 /MaxReadThrough="0.727580000000001" /MaxDrop="6.86927" /score="-1.24586831" /energy="-7.7" /TU="NA" /idTUdmin="U892" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1112323..1112330 /Source="Nicolas_upshift_promotors" /id="U891" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78021978021978" /psig="0.996003996003996" /xcortree=2481 /SigmaFactorBS="gtaaaaatgtgttcaagctggctgcaaaagtTCTTTACAgac gtttcaatttcTTGTATTGTATTCCCGTTGAtacagagatcggcagcatgccggacag c" /listShort="S395, yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1112345..1112364 /Source="Nicolas_upshift_promotors" /id="U891" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78021978021978" /psig="0.996003996003996" /xcortree=2481 /SigmaFactorBS="gtaaaaatgtgttcaagctggctgcaaaagtTCTTTACAgac gtttcaatttcTTGTATTGTATTCCCGTTGAtacagagatcggcagcatgccggacag c" /listShort="S395, yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1112350..1112875 /Source="Nicolas_S_feature" /locus_tag="new_1188125_1188650" /HighExp="G180, Paraq, G135, G150, Oxctl, C30, H2O2, LBGstat, LBGexp, Lbexp" /AntisenseName="yitS" /AntisenseCor="-0.45830528686941202" /AntisenseRegPval="-14.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S395" upshifts 1112352 /Source="Nicolas_upshifts" /id="U891" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78021978021978" /psig="0.996003996003996" /xcortree=2481 /SigmaFactorBS="gtaaaaatgtgttcaagctggctgcaaaagtTCTTTACAgac gtttcaatttcTTGTATTGTATTCCCGTTGAtacagagatcggcagcatgccggacag c" /listShort="S395, yitT, S396, ipi" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1112817..1112836) /Source="Nicolas_upshift_promotors" /id="U892" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.558441558441558" /psig="0.841158841158841" /xcortree=594 /SigmaFactorBS="gctctttcttctttattatgttttcccttaaaacaaatattt gaAcacgattttggcaaattaaTATGATATAGTTGGCTTAACtctcatgataacgagc g" /listShort="yitS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1112840) /Source="Nicolas_upshifts" /id="U892" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.558441558441558" /psig="0.841158841158841" /xcortree=594 /SigmaFactorBS="gctctttcttctttattatgttttcccttaaaacaaatattt gaAcacgattttggcaaattaaTATGATATAGTTGGCTTAACtctcatgataacgagc g" /listShort="yitS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1112854..1112859 /Source="Nicolas_upshift_promotors" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1112874..1112892 /Source="Nicolas_upshift_promotors" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1112877 /Source="Nicolas_upshifts" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="upshifts" CDS 1112914..1113756 /gene="yitT" /locus_tag="BSU_11120" /old_locus_tag="BSU11120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23419162, 23824080; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388993.1" /db_xref="EnsemblGenomes-Gn:BSU11120" /db_xref="EnsemblGenomes-Tr:CAB12952" /db_xref="GOA:P39803" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG10850" /db_xref="UniProtKB/Swiss-Prot:P39803" /translation="MVLDQTKKLLIVIIGALLNAAGLNLFLIPADVYASGFTGVAQLL SSVVDQYAPFYISTGTLLFLLNIPVGILGWLKVGKSFTVYSILSVALTTLFMGILPET SLSHDILLNAVFGGVISAVGIGLTLKYGASTGGLDIVAMVLAKWKDKPVGTYFFILNG IIILTAGLLQGWEKALYTLVTLYVTTRVIDAIHTRHMKLTAMIVTKKADEIKEAIYGK MVRGITTVPAKGAFTNEQKEMMIIVITRYELYDLEKIVKEVDPKAFTNIVQTTGIFGF FRKD*" /label="yitT CDS" gene 1112914..1113756 /gene="yitT" /locus_tag="BSU_11120" /old_locus_tag="BSU11120" /label="yitT gene" promotor_-35 1113409..1113417 /Source="Nicolas_upshift_promotors" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1113428..1113446 /Source="Nicolas_upshift_promotors" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1113428 /Source="Nicolas_upshifts" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="upshifts" S_feature 1113757..1113870 /Source="Nicolas_S_feature" /locus_tag="new_1189532_1189645" /HighExp="Etha, S8, Sw, M9-stat, S7, BC, Gly, S6, Salt, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigB, SigA" /TUshortPSig="0.968, 0.998, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S396" CDS 1113871..1114230 /gene="ipi" /locus_tag="BSU_11130" /old_locus_tag="BSU11130" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8226659, 24555072" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8226659, 24555072; Product type f: factor" /codon_start=1 /transl_table=11 /product="intracellular proteinase inhibitor BsuPI" /protein_id="NP_388994.1" /db_xref="EnsemblGenomes-Gn:BSU11130" /db_xref="EnsemblGenomes-Tr:CAB12953" /db_xref="GOA:P39804" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR020481" /db_xref="PDB:3ISY" /db_xref="SubtiList:BG10852" /db_xref="UniProtKB/Swiss-Prot:P39804" /translation="MENQEVVLSIDAIQEPEQIKFNMSLKNQSERAIEFQFSTGQKFE LVVYDSEHKERYRYSKEKMFTQAFQNLTLESGETYDFSDVWKEVPEPGTYEVKVTFKG RAENLKQVQAVQQFEVK*" /label="ipi CDS" gene 1113871..1114230 /gene="ipi" /locus_tag="BSU_11130" /old_locus_tag="BSU11130" /label="ipi gene" downshifts 1114219 /Source="Nicolas_upshifts" /id="D605" /incds=0 /nref=34 /ntot=224 /MaxReadThrough="1.36729" /MaxDrop="5.6855" /score="43.7575824" /energy="-15.6" /TU="NA" /idTUdmin="U893" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1114261..1114458) /gene="yizC" /locus_tag="BSU_11139" /old_locus_tag="BSU11139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; genus orphan" /protein_id="YP_003097702.1" /db_xref="EnsemblGenomes-Gn:BSU11139" /db_xref="EnsemblGenomes-Tr:CAX52590" /db_xref="InterPro:IPR024217" /db_xref="UniProtKB/Swiss-Prot:C0H3Y5" /translation="MRNELFQQAKSFVQQAVMVTNGFEEGDQEQAILRAKNAVSSAYA NSTDAERQQLHQFQNQLDKLQ*" /label="yizC CDS" gene complement(1114261..1114458) /gene="yizC" /locus_tag="BSU_11139" /old_locus_tag="BSU11139" /label="yizC gene" downshifts complement(1114274) /Source="Nicolas_upshifts" /id="D606" /incds=0 /nref=150 /ntot=257 /MaxReadThrough="1.42333" /MaxDrop="8.284" /score="2.35557074" /energy="-17.3" /TU="NA" /idTUdmin="U895" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1114459..1114655) /Source="Nicolas_S_feature" /locus_tag="new_1190234_1190430_c" /HighExp="S8, S6, S5, S7, nit, ferm, BT, G/S, Pyr, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99834599999999996" /TUshortSig="SigGF, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S397" upshifts complement(1114655) /Source="Nicolas_upshifts" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1114657..1114668) /Source="Nicolas_upshift_promotors" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1114683..1114689) /Source="Nicolas_upshift_promotors" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1114715..1115527) /gene="ribZC" /locus_tag="BSU_11140" /old_locus_tag="BSU11140" /function="4.9: Riboflavin, FMN, and FAD" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 25012491, 26316208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-amino-6-ribitylamino-2,4(1H, 3H)-pyrimidinedione 5'-phosphate phosphatase (promiscuous)" /protein_id="NP_388995.1" /db_xref="EnsemblGenomes-Gn:BSU11140" /db_xref="EnsemblGenomes-Tr:CAB12954" /db_xref="GOA:P70947" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG12245" /db_xref="UniProtKB/Swiss-Prot:P70947" /translation="METKPYLIALDLDGTLLKDDKTISENTLHTIQRLKDDGHYVCIS TGRPYRSSSMYYQQMELTTPIVNFNGAFVHHPQDDSWGRYHTSLPLDVVKQLVDISES YNVHNVLAEVIDDVYFHYHDEHLIDAFNMNTTNVTVGDLRENLGEDVTSVLIHAKEED VPAIRSYLSDVHAEVIDHRRWAAPWHVIEIIKSGMNKAVGLQKISDYYGVPRERIIAF GDEDNDLEMLEFAGCGVAMGNGIDAVKQIANRTTATNEEDGVARFLKEYFSL*" /label="ribZC CDS" gene complement(1114715..1115527) /gene="ribZC" /locus_tag="BSU_11140" /old_locus_tag="BSU11140" /label="ribZC gene" promotor_-10 complement(1115565..1115584) /Source="Nicolas_upshift_promotors" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1115585..1115592 /Source="Nicolas_upshift_promotors" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1115585) /Source="Nicolas_upshifts" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1115598..1115605) /Source="Nicolas_upshift_promotors" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1115604..1115623 /Source="Nicolas_upshift_promotors" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1115606 /Source="Nicolas_upshifts" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="upshifts" CDS 1115648..1116415 /gene="yitV" /locus_tag="BSU_11150" /old_locus_tag="BSU11150" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28293230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxylesterase" /protein_id="NP_388996.1" /db_xref="EnsemblGenomes-Gn:BSU11150" /db_xref="EnsemblGenomes-Tr:CAB12955" /db_xref="GOA:P70948" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12246" /db_xref="UniProtKB/Swiss-Prot:P70948" /translation="MIQIENQTVSGIPFLHIVKEENRHRAVPLVIFIHGFTSAKEHNL HIAYLLAEKGFRAVLPEALHHGERGEEMAVEELAGHFWDIVLNEIEEIGVLKNHFEKE GLIDGGRIGLAGTSMGGITTLGALTAYDWIKAGVSLMGSPNYVELFQQQIDHIQSQGI EIDVPEEKVQQLMKRLELRDLSLQPEKLQQRPLLFWHGAKDKVVPYAPTRKFYDTIKS HYSEQPERLQFIGDENADHKVPRAAVLKTIEWFETYL*" /label="yitV CDS" gene 1115648..1116415 /gene="yitV" /locus_tag="BSU_11150" /old_locus_tag="BSU11150" /label="yitV gene" promotor_-35 1116424..1116430 /Source="Nicolas_upshift_promotors" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1116444 /Source="Nicolas_upshifts" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1116445..1116464 /Source="Nicolas_upshift_promotors" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1116479..1116787 /gene="yitW" /locus_tag="BSU_11160" /old_locus_tag="BSU11160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9209063; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative protein involved in Fe-S cluster assembly, PaaD-like" /protein_id="NP_388997.1" /db_xref="EnsemblGenomes-Gn:BSU11160" /db_xref="EnsemblGenomes-Tr:CAB12956" /db_xref="InterPro:IPR002744" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG12247" /db_xref="UniProtKB/Swiss-Prot:P70949" /translation="MEEALKENIMGALEQVVDPELGVDIVNLGLVYDVDMDEDGLTHI TMTLTSMGCPLAPIIVDEVKKALADLPEVKDTEVHIVWNPPWTRDKMSRYAKIALGIQ *" /label="yitW CDS" gene 1116479..1116787 /gene="yitW" /locus_tag="BSU_11160" /old_locus_tag="BSU11160" /label="yitW gene" downshifts 1116772 /Source="Nicolas_upshifts" /id="D607" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="5.65659" /MaxDrop="4.5598" /score="14.9971829" /energy="-14.7" /TU="U897,U898" /idTUdmin="U897" /TUdmin="-2244" /isTUend="FALSE" /label="downshifts" S_feature 1116817..1117082 /Source="Nicolas_S_feature" /locus_tag="new_1192592_1192857" /HighExp="Etha, dia15, dia5, H2O2, LoTm, Salt, S6, Diami, S8, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba=1 /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S398" CDS 1117083..1118513 /gene="yitY" /locus_tag="BSU_11170" /old_locus_tag="BSU11170" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 16956367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FMN/FAD-binding oxidoreductase" /protein_id="NP_388999.3" /db_xref="EnsemblGenomes-Gn:BSU11170" /db_xref="EnsemblGenomes-Tr:CAB12958" /db_xref="GOA:Q796P5" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR016164" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12249" /db_xref="UniProtKB/Swiss-Prot:Q796P5" /translation="MKKKLLAFALCTGAYAALFAYSVNSEQKTATSEMTDVSRLMPVK IKQTVKGQEEEMLIDTVKEANRKNIKISIAGAQHSMGGHTYYEDGIVLDMTGYNKILS LDQEKKTIRVQSGATWNDIQKYVNPYGLAVKVMQSQNIFTIGGSLSANAHGRDIRYGS LIDTVKSFRLLKADGMIITVTPKDDLFTAVIGGYGLFGVILDVTLELTDDELYVMKTE KMNYSTYSDYFSKHVKGNPDVRMHLARISTAKKGFLKDMYVTNYVLANHQDQLSSYSE LKEDEYTGATKFALGLSRRYEWGRNWLWDTQQSYFLSQNGTEISRNNVMRSESKFLEY ENNDNTDVLQEYFVPVKEYGSYIDDLRQTLSDEDLNLLNITIRYVQKNEKADLSYAKD DMFSLVLLINEGFSKEDQADTARIIRRMTDVAIKHGGSYYLPYMTYQTKAQMRQAYPK SEAFFQKKRTYDPDERFMNYFYQRYK*" /label="yitY CDS" gene 1117083..1118513 /gene="yitY" /locus_tag="BSU_11170" /old_locus_tag="BSU11170" /label="yitY gene" CDS 1118558..1119052 /gene="yitZ" /locus_tag="BSU_11180" /old_locus_tag="BSU11180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative transport protein" /protein_id="NP_389000.1" /db_xref="EnsemblGenomes-Gn:BSU11180" /db_xref="EnsemblGenomes-Tr:CAB12959" /db_xref="GOA:P70952" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12250" /db_xref="UniProtKB/Swiss-Prot:P70952" /translation="MFFASSLIFPFYILFVKNIGSSYTQFGFSYGLFGLSGALIYPLL GRLSERFDSRYFLLLNSWGMAVLLLYVPHIGSVVQVYIVQVLLGLFGAMQKHGEKVLI ANFTDSGERGKKIGNYHFWTAVFSAAAIMLGGFLADFFTVQMIFYASSILYFLSGLMM MKTG*" /label="yitZ CDS" gene 1118558..1119052 /gene="yitZ" /locus_tag="BSU_11180" /old_locus_tag="BSU11180" /label="yitZ gene" downshifts 1119016 /Source="Nicolas_upshifts" /id="D608" /incds=0 /nref=49 /ntot=208 /MaxReadThrough="1.74762" /MaxDrop="4.22077" /score="34.1294744" /energy="-13.2" /TU="NA" /idTUdmin="U897" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1119190..1119197 /Source="Nicolas_upshift_promotors" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1119196 /Source="Nicolas_upshifts" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1119211..1119230 /Source="Nicolas_upshift_promotors" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1119259..1120296 /gene="argC" /locus_tag="BSU_11190" /old_locus_tag="BSU11190" /EC_number="1.2.1.38" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2117746, 3005232, 3106155, 6096674, 6096675, 8025667, 18455186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117746, 3005232, 3106155, 6096674, 6096675, 8025667, 18455186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglutamate gamma-semialdehyde dehydrogenase" /protein_id="NP_389001.2" /db_xref="EnsemblGenomes-Gn:BSU11190" /db_xref="EnsemblGenomes-Tr:CAB12960" /db_xref="GOA:P23715" /db_xref="InterPro:IPR000534" /db_xref="InterPro:IPR000706" /db_xref="InterPro:IPR012280" /db_xref="InterPro:IPR023013" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10191" /db_xref="UniProtKB/Swiss-Prot:P23715" /translation="MKIGIVGATGYGGTELVRILSHHPHAEECILYSSSGEGNVYSEG YPHLTGLADQQLKPIDMNTIKHEIDIMFLAAPPGVSSELTPKLADAGITVIDLSGDLR IKEPAEYEKWYKRTAAPKAVIQEAVYGLAELNQLQIQQAKLIANPGCFPTAVLLGLAP LAQKKLLDESFVIVDAKTGVSGAGRKASMGTHFSELNDNFKIYKVNEHQHTPEIEQAL NEWQPGLGPITFSAHLVPMTRGIMATMYTRLTCDLTADDLHDLYSEFYQDSYFVRVRP KGQYPQTKEVYGSNFCDIAVTLDERTNRVTIVSVIDNLMKGAAGQAVQNFNLMNGWNE ETGLTITPIYP*" /label="argC CDS" gene 1119259..1120296 /gene="argC" /locus_tag="BSU_11190" /old_locus_tag="BSU11190" /label="argC gene" CDS 1120316..1121536 /gene="argJ" /locus_tag="BSU_11200" /old_locus_tag="BSU11200" /EC_number="2.3.1.1" /EC_number="2.3.1.35" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8025667, 10931207, 16409639, 24163341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8025667, 10931207, 16409639, 24163341; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ornithine acetyltransferase; amino-acid acetyltransferase" /protein_id="NP_389002.2" /db_xref="EnsemblGenomes-Gn:BSU11200" /db_xref="EnsemblGenomes-Tr:CAB12961" /db_xref="GOA:P36843" /db_xref="InterPro:IPR002813" /db_xref="InterPro:IPR016117" /db_xref="SubtiList:BG10192" /db_xref="UniProtKB/Swiss-Prot:P36843" /translation="MIQLSEDQIVKVTGDVSSPKGFQAKGVHCGLRYSKKDLGVIISE TPAVSAAVYTQSHFQAAPIKVTQDSLKHGPTLKAVIVNSAIANACTGEQGLKDAYTMR ESFASQLGIEPELVAVSSTGVIGEHLDMEKIHAGIELLKETPAGSGDFEEAILTTDTV IKQTCYELAIGGKTVTIGGAAKGSGMIHPNMATMLGFVTTDAAIEEKALQKALREITD VSFNQITVDGETSTNDMVLVMANGCAENECLTEDHPDWPVFKKALLLTCEDLAKEIAR DGEGATKLIEAQVQGAKNNLDANVIAKKIVGSNLVKTAVYGTDANWGRIIGAIGHSAA QVTAEEVEVYLGGQCLFKNNEPQPFSESIAKEYLEGDEITIVIKMAEGDGNGRAWGCD LTYDYIKINASYRT*" /label="argJ CDS" gene 1120316..1121536 /gene="argJ" /locus_tag="BSU_11200" /old_locus_tag="BSU11200" /label="argJ gene" CDS 1121551..1122327 /gene="argB" /locus_tag="BSU_11210" /old_locus_tag="BSU11210" /EC_number="2.7.2.8" /experiment="publication(s) with functional evidences, PMID:3005232, 8473852" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3005232, 8473852; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglutamate 5-phosphotransferase (acetylglutamate kinase)" /protein_id="NP_389003.1" /db_xref="EnsemblGenomes-Gn:BSU11210" /db_xref="EnsemblGenomes-Tr:CAB12962" /db_xref="GOA:P68729" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR004662" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10193" /db_xref="UniProtKB/Swiss-Prot:P68729" /translation="MKKTIVFKCGGSVIRELSEEFYQNLKELRASGWKLAIVHGGGPE ITNMLKRLNIKTEFSGGQRKTTKPVLEVAEMVLSGSVNKFFVAELAKHGLRAAGISGK DGGLLEADYLDPETYGEVGEIKKVDASMVNALMENGIIPVIAPLSMTSDCKTLNVNAD LAASAVAGALEADKLMFVTDVDGIMKEKQRLDVLTPKEIQMLIKQEVITGGMIPKVNS ALSALSDQVSEVMIVNGKGSFFAEQTFQGTKIVKAKEAVS*" /label="argB CDS" gene 1121551..1122327 /gene="argB" /locus_tag="BSU_11210" /old_locus_tag="BSU11210" /label="argB gene" CDS 1122324..1123481 /gene="argD" /locus_tag="BSU_11220" /old_locus_tag="BSU11220" /EC_number="2.6.1.11" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17012789; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N-acetylornithine aminotransferase" /protein_id="NP_389004.2" /db_xref="EnsemblGenomes-Gn:BSU11220" /db_xref="EnsemblGenomes-Tr:CAB12963" /db_xref="GOA:P36839" /db_xref="InterPro:IPR004636" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10194" /db_xref="UniProtKB/Swiss-Prot:P36839" /translation="MSSLFQTYGRWDIDIKKAKGTYVEDQNGKTYLDFIQGIAVSNLG HCHEAVTEAVKKQLDSVWHVSNLFQNSLQEQAAQKLAAHSAGDLVFFCNSGAEANEGA IKLARKATGKTKIITFLQSFHGRTYAGMAATGQDKIKTGFGPMLGGFHYLPYNDPSAF KALGEEGDIAAVMLETVQGEGGVNPASAEFLSAVQSFCKEKQALLIIDEIQTGIGRTG KGFAYEHFGLSPDIITVAKGLGNGFPVGAVIGKKQLGEAFTPGSHGTTFGGNMLAMAA VNATLQIVFQPDFLQEAADKGAFLKEQLEAELKSPFVKQIRGKGLMLGIECDGPVADI IAELQTLGLLVLPAGPNVIRLLPPLTVTKDEIAEAVSKLKQAIAHHSAVNQ*" /label="argD CDS" gene 1122324..1123481 /gene="argD" /locus_tag="BSU_11220" /old_locus_tag="BSU11220" /label="argD gene" CDS 1123552..1124607 /gene="carA" /locus_tag="Delta6_BSU_11230_SNPvariant" /old_locus_tag="BSU_11230" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:216664, 230177, 1116335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 216664, 230177, 1116335; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine-specific carbamoyl-phosphate synthetase(small subunit)" /protein_id="NP_389005.2" /db_xref="EnsemblGenomes-Gn:BSU11230" /db_xref="EnsemblGenomes-Tr:CAB12964" /db_xref="GOA:P36838" /db_xref="InterPro:IPR002474" /db_xref="InterPro:IPR006274" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR035686" /db_xref="InterPro:IPR036480" /db_xref="SubtiList:BG10195" /db_xref="UniProtKB/Swiss-Prot:P36838" /modified_by="User" /translation="MEGYLVLEDGTSFSGELDGHENCTGEAVFFTGMTGYQEVLTDPS YKGQIIVFTYPLIGNYGINEKDFESKKPQVKAAVVYEACDHFSHYEAVYSLKEYLQKW NIPLLTHVDTRAVVKKIRANGTMGATVTASKEGAEIALQPENVAEQASAQEISTFGDG NKHIALIDFGYKKSIASSLVKRGCKVTVVPYQQMEAVYNIKPDGLSNGPGDPKAIQPY LGKIKSIISRFPTLGICLGHQLIALAFGGNTFKLPFGHRGANHPVIDRKTKRVFMTSQ NHSYVVDEQSINEEELTIRFHHVNDTSVEGLAHKKLPVMSVQFHPEAHPGPAESEWIF DDYLKNVIPARREIAHA*" /label="Delta6_BSU_11230_SNPvariant" gene 1123552..1124607 /gene="carA" /locus_tag="Delta6_BSU_11230_SNPvariant" /old_locus_tag="BSU_11230" /modified_by="User" /label="Delta6_BSU_11230_SNPvariant" Polymorphism join(1124162,1124163) /Source="geneious" /ID="SNP_BsDelta6_1199938_1199943" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=6 /Amino_Acid_Change="GIV -> G" /CDS_Position=612 /Change="-AATTGT" /Codon_Change="GGA,ATT,GTG -> GGG" /Coverage="183 -> 185" /locus_tag="BSU_11230" /Protein_Effect="Deletion" /Reference_Frequency /Reference_Nucleotides="AATTGT" /Variant_Nucleotides /Variant_P_Value=0 /Variant_Raw_Frequency=174 /comment="Delta6_BSU_11230_SNPvariant" / /modified_by="User" /label="Polymorphism_Delta6" misc_feature complement(1124441..1124460) /Source="Nicolas_upshift_promotors" /id="U900" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.869130869130869" /psig="0.949050949050949" /xcortree=2066 /SigmaFactorBS="gtggaattgaacactcatgacaggcagttttttatgggcaag cccttcaacTGACGTATCATTGACATGATgaaacctgatggtgagctcttcttcatta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1124451) /Source="Nicolas_upshifts" /id="U900" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.869130869130869" /psig="0.949050949050949" /xcortree=2066 /SigmaFactorBS="gtggaattgaacactcatgacaggcagttttttatgggcaag cccttcaacTGACGTATCATTGACATGATgaaacctgatggtgagctcttcttcatta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1124600..1127692 /gene="carB" /locus_tag="BSU_11240" /old_locus_tag="BSU11240" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:216664, 1116335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 216664, 1116335; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine-specific carbamoyl-phosphate synthetase(large subunit)" /protein_id="NP_389006.3" /db_xref="EnsemblGenomes-Gn:BSU11240" /db_xref="EnsemblGenomes-Tr:CAB12965" /db_xref="GOA:P18185" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005480" /db_xref="InterPro:IPR005483" /db_xref="InterPro:IPR006275" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR036897" /db_xref="SubtiList:BG10196" /db_xref="UniProtKB/Swiss-Prot:P18185" /translation="MPKDTSISSILVIGSGPIIIGQAAEFDYSGTQGCIALKEEGYRV ILVNSNPATIMTDEAFADEIYFEPLTAESLTAIIKKERPDGLLANLGGQTALNLAVEL EETGVLKEHGVKLLGTSVETIQKGEDREKFRSLMNELKQPVPESEIVDNEADALHFAE SIGFPVIIRPAYTLGGKGGGIAPDKEAFTAMIKQALLASPINQCLVEKSIAGFKEIEY EVMRDSNNTCITVCNMENIDPVGVHTGDSIVVAPSQTLTDEDYQMLRTASLTIISALD VVGGCNIQFALDPFSKQYYVIEVNPRVSRSSALASKATGYPIAKMAAKLAVGYTLDEL KNPLTGSTYASFEPALDYVIVKFPRWPFDKFKNADRKLGTKMKATGEVMAIERNLEAA IQKAAASLELKNIGTHLPELSGLSIDTLWDLAITPDDRRFFVVMELLSRSVSIDDIHE KTKIDPFFLHTFDNIIKLENRLMEAGSDLSFELLKKAKEKGFSDATIASLISKTEEEV RALRKEMGITPSFKIVDTCAAEFDAKTNYFYSTYFGETDGDISRKEKKRALIIGSGPI RIGQGVEFDYSAVHGVLTLQELGFETIMINNNPETVSTDYEIADRLYFEPMTTEHIVN VAEQENIDFAIVQFGGQTAINAAEALEKAGITLLGTSFQTLDVLEDRDQFYQLLDELG LKHAKGEIAYTKEEAASKASEIGYPVLIRPSYVIGGMGMIIVDSQAQLSQLLNDEDSM PYPILIDQYVSGKEVEIDLISDGEEVFIPTYTEHIERAGVHSGDSFAILPGPSITSGL QQGMKDAAQKIARKLSFKGIMNIQFVIDNGNILVLEVNPRASRTVPVVSKVMGVPMIP LATRLLAGASLKDLNPAVQNHHGVAVKFPVFSSHAIQDVDVKLGPEMKSTGEGMCVAY DSNSALKKIYTRVWSQKGSIYLQNVPEDVKELAENAGFTIHEGTFASWMEQEGNSLHI NLSGSEEARKERLEAMTHGIPVFTEEETVRAFLQSGSGHPQPVSLKDLYKKEVASCTQ *" /label="carB CDS" gene 1124600..1127692 /gene="carB" /locus_tag="BSU_11240" /old_locus_tag="BSU11240" /label="carB gene" CDS 1127680..1128639 /gene="argF" /locus_tag="BSU_11250" /old_locus_tag="BSU11250" /EC_number="2.1.3.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3099126, 6409881, 8025667, 9346304, 16585758, 26443366" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3099126, 6409881, 8025667, 9346304, 16585758, 26443366; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ornithine carbamoyltransferase" /protein_id="NP_389007.1" /db_xref="EnsemblGenomes-Gn:BSU11250" /db_xref="EnsemblGenomes-Tr:CAB12966" /db_xref="GOA:P18186" /db_xref="InterPro:IPR002292" /db_xref="InterPro:IPR006130" /db_xref="InterPro:IPR006131" /db_xref="InterPro:IPR006132" /db_xref="InterPro:IPR024904" /db_xref="InterPro:IPR036901" /db_xref="SubtiList:BG10197" /db_xref="UniProtKB/Swiss-Prot:P18186" /translation="MHTVTQTSLYGKDLLTLKDLSEEDINALLAEAGELKQNKIQPIF HGKTLAMIFEKSSTRTRVSFEAGMAQLGGSALFLSQKDLQLGRGETVADTAKVLSGYV DAIMIRTFEHEKVEELAKEADIPVINGLTDKYHPCQALADLLTIKEIKGKLKGVKVAY IGDGNNVAHSLMIGCAKMGCDISIASPKGYEVLDEAAEAAKTYALQSGSSVTLTDDPI EAVKDADVIYSDVFTSMGQEAEEQERLAVFAPYQVNAALVSHAKPDYTFLHCLPAHRE EEVTAEIIDGPNSAVFQQAENRLHVQKALLKAILYKGESSKNC*" /label="argF CDS" gene 1127680..1128639 /gene="argF" /locus_tag="BSU_11250" /old_locus_tag="BSU11250" /label="argF gene" downshifts 1128602 /Source="Nicolas_upshifts" /id="D609" /incds=0 /nref=141 /ntot=268 /MaxReadThrough="4.29547" /MaxDrop="7.69347" /score="22.2660758" /energy="-11.1" /TU="U899" /idTUdmin="U899" /TUdmin="-305" /isTUend="FALSE" /label="downshifts" S_feature complement(1128642..1128916) /Source="Nicolas_S_feature" /locus_tag="new_1204423_1204697_c" /HighExp="G135, G180, Cold, LBGexp, G150, B60, LoTm, Paraq, Oxctl, H2O2" /AntisenseName="yjzC" /AntisenseCor="-0.37122740772860502" /AntisenseRegPval="-9.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S399" promotor_-35 1128667..1128673 /Source="Nicolas_upshift_promotors" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1128675) /Source="Nicolas_upshifts" /id="D610" /incds=0 /nref=33 /ntot=166 /MaxReadThrough="1.19008" /MaxDrop="5.22155" /score="16.2777759" /energy="-11.2" /TU="NA" /idTUdmin="U902" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 1128688..1128699 /Source="Nicolas_upshift_promotors" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1128709 /Source="Nicolas_upshifts" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="upshifts" CDS 1128725..1128904 /gene="yjzC" /locus_tag="BSU_11260" /old_locus_tag="BSU11260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25859258" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389008.1" /db_xref="EnsemblGenomes-Gn:BSU11260" /db_xref="EnsemblGenomes-Tr:CAB12967" /db_xref="InterPro:IPR025549" /db_xref="SubtiList:BG13223" /db_xref="UniProtKB/Swiss-Prot:O34585" /translation="MGQQHQFRPGQKAPNNGVYVEIGETGSMVKNPQKVHLSAGEMFP ETSNHNRLWTYKRKP*" /label="yjzC CDS" gene 1128725..1128904 /gene="yjzC" /locus_tag="BSU_11260" /old_locus_tag="BSU11260" /label="yjzC gene" downshifts 1128914 /Source="Nicolas_upshifts" /id="D611" /incds=0 /nref=19 /ntot=53 /MaxReadThrough="0.25116" /MaxDrop="5.67653" /score="4.8153862" /energy="-10.9" /TU="NA" /idTUdmin="U899" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1128950..1129135) /gene="yjzD" /locus_tag="BSU_11270" /old_locus_tag="BSU11270" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:19775244" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19775244; Product type f: factor" /codon_start=1 /transl_table=11 /product="forespore targeted protein" /protein_id="NP_389009.1" /db_xref="EnsemblGenomes-Gn:BSU11270" /db_xref="EnsemblGenomes-Tr:CAB12968" /db_xref="GOA:O34713" /db_xref="InterPro:IPR021324" /db_xref="SubtiList:BG13224" /db_xref="UniProtKB/Swiss-Prot:O34713" /translation="MRYIIAFIWTFLLSHMACYLVASMNSVTYNFKTSSVIAVVLYVL IMVLAEIMPMNKNASQH*" /label="yjzD CDS" gene complement(1128950..1129135) /gene="yjzD" /locus_tag="BSU_11270" /old_locus_tag="BSU11270" /label="yjzD gene" downshifts complement(1128961) /Source="Nicolas_upshifts" /id="D612" /incds=0 /nref=215 /ntot=261 /MaxReadThrough="3.91391" /MaxDrop="6.26103" /score="9.62656276" /energy="-10.9" /TU="U902" /idTUdmin="U902" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1129164..1129183) /Source="Nicolas_upshift_promotors" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1129181) /Source="Nicolas_upshifts" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1129194..1129201) /Source="Nicolas_upshift_promotors" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1129236..1129242 /Source="Nicolas_upshift_promotors" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1129254..1129273 /Source="Nicolas_upshift_promotors" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1129259 /Source="Nicolas_upshifts" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1129316..1129325 /Source="Nicolas_upshift_promotors" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1129325 /Source="Nicolas_upshifts" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1129338..1129357 /Source="Nicolas_upshift_promotors" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1129384..1130118 /gene="yjaU" /locus_tag="BSU_11280" /old_locus_tag="BSU11280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 18582593" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389010.1" /db_xref="EnsemblGenomes-Gn:BSU11280" /db_xref="EnsemblGenomes-Tr:CAB12969" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13124" /db_xref="UniProtKB/Swiss-Prot:O35001" /translation="MGITERYFQLGTEHNVIHLPYRPNGFGIFILGDRTHFVGHDSSF WQQHYGRNQLLSMLMNEGYTLFNSNLFGRHWGAEKAVTYAKQLIHSVLKQEILNPKIH ILAEGMGALVADELLRFSPDHIRSAAMLNPCLDLQAHYESEKENKFFYKQFLKEVSKS YGISEKEAEAIRYKTIQSYPSGVPVHIWQRMTGAPYPYSVHAEVFKEKQQKQGSPVDM TFHLFEHPSRIYASICKFFHSHEKEL*" /label="yjaU CDS" gene 1129384..1130118 /gene="yjaU" /locus_tag="BSU_11280" /old_locus_tag="BSU11280" /label="yjaU gene" S_feature complement(1129877..1130479) /Source="Nicolas_S_feature" /locus_tag="new_1205658_1206260_c" /HighExp="S8, S6, S7, C30, BT, S4, S5, Pyr, S3, C90" /AntisenseName="yjaV" /AntisenseCor="0.66207512383157796" /AntisenseRegPval="-34.6" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.468" /TUlongSig="NA" /TUlongPSig="NA" /label="S400" promotor_-35 1130099..1130104 /Source="Nicolas_upshift_promotors" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1130117 /Source="Nicolas_upshifts" /id="D613" /incds=0 /nref=6 /ntot=47 /MaxReadThrough="5.56163" /MaxDrop="4.5381" /score="1.90624641" /energy="-10" /TU="U904,U905" /idTUdmin="U904" /TUdmin="-945" /isTUend="FALSE" /label="downshifts" upshifts 1130117 /Source="Nicolas_upshifts" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1130120..1130138 /Source="Nicolas_upshift_promotors" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1130200..1130757 /gene="yjaV" /locus_tag="BSU_11290" /old_locus_tag="BSU11290" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14523133; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P) binding enzyme" /protein_id="NP_389011.2" /db_xref="EnsemblGenomes-Gn:BSU11290" /db_xref="EnsemblGenomes-Tr:CAB12970" /db_xref="SubtiList:BG13125" /db_xref="UniProtKB/Swiss-Prot:O34959" /translation="MESTLIVGADEFFGLSLCERMMDEGIHVDVVLAETEDKMRQMYL EERLMWLGRNELFRQLEHIGDQNYDTICIQFGSFLPLDQYDSPYILVYEEDRKEWDKR EKTGSEKTVILPKMYGPWKEETEEDGYYTNDVADELLRFLLEPSRHSKDQLFELQVTE KTSKEEAKTKIIEWKRQFSSIFDKY*" /label="yjaV CDS" gene 1130200..1130757 /gene="yjaV" /locus_tag="BSU_11290" /old_locus_tag="BSU11290" /label="yjaV gene" promotor_-10 complement(1130459..1130478) /Source="Nicolas_upshift_promotors" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1130479) /Source="Nicolas_upshifts" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1130493..1130497) /Source="Nicolas_upshift_promotors" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1130764..1130771 /Source="Nicolas_upshift_promotors" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="promotor_-35" promotor_-10 1130786..1130805 /Source="Nicolas_upshift_promotors" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="promotor_-10" upshifts 1130798 /Source="Nicolas_upshifts" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="upshifts" CDS 1130848..1131801 /gene="med" /locus_tag="BSU_11300" /old_locus_tag="BSU11300" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1203607, 21622736, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1203607, 21622736, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="positive regulator of comK" /protein_id="NP_389012.2" /db_xref="EnsemblGenomes-Gn:BSU11300" /db_xref="EnsemblGenomes-Tr:CAB12971" /db_xref="GOA:O32436" /db_xref="InterPro:IPR003760" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13126" /db_xref="UniProtKB/Swiss-Prot:O32436" /translation="MITRLVMIFSVLLLLSGCGQTPFKGKIEKVGMLFPDTINDLVWG TKGYKGLLNIQSKYNVDVYYKEGVKTEEDIINAIEDFHKRGVNLLYGHGSEYAEVFNL VGEDYPDMEFVISNAKAKADNVTSVHFSGEAMGFFGGMTAAHMSKTNQVGVIASFTWQ PEVDGFIKGAKYENPDIEVNTKYTDHWDDDTTAVKLYQKMKNEGADVVYPAGDGYNVP VIQQIKKDGLYAIGYVTDQSDLGENTVLTSTVQNVDKAYEIIAEQFNKGTLEGGDHYY DLNTGVVEMGTFSPLVDQDFQQRIAKLIKTYNKTGELPKNE*" /label="med CDS" gene 1130848..1131801 /gene="med" /locus_tag="BSU_11300" /old_locus_tag="BSU11300" /label="med gene" promotor_-35 1131465..1131469 /Source="Nicolas_upshift_promotors" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="promotor_-35" promotor_-10 1131485..1131504 /Source="Nicolas_upshift_promotors" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="promotor_-10" upshifts 1131498 /Source="Nicolas_upshifts" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="upshifts" CDS 1131816..1132007 /gene="comZ" /locus_tag="BSU_11310" /old_locus_tag="BSU11310" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10940045; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative late competence gene" /protein_id="NP_389013.1" /db_xref="EnsemblGenomes-Gn:BSU11310" /db_xref="EnsemblGenomes-Tr:CAB12972" /db_xref="GOA:O32437" /db_xref="InterPro:IPR024558" /db_xref="SubtiList:BG13221" /db_xref="UniProtKB/Swiss-Prot:O32437" /translation="MQHEKSLEFLQIAMKYLPEAKEQLEKSGIELSMEAIQPFMNLFT TVMAEAYELGKSDAKSETE*" /label="comZ CDS" gene 1131816..1132007 /gene="comZ" /locus_tag="BSU_11310" /old_locus_tag="BSU11310" /label="comZ gene" downshifts 1131986 /Source="Nicolas_upshifts" /id="D614" /incds=0 /nref=32 /ntot=192 /MaxReadThrough="4.56858" /MaxDrop="3.45953" /score="-7.49795364" /energy="-10.4" /TU="U907,U908" /idTUdmin="U905" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1132031..1132371 /Source="Nicolas_S_feature" /locus_tag="new_1207812_1208152" /HighExp="H2O2, C30, G135, Paraq, G180, G150, Oxctl, Cold, dia15, LPh" /AntisenseName="yjzB" /AntisenseCor="-0.34349942363230701" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S401" CDS complement(1132037..1132276) /gene="yjzB" /locus_tag="BSU_11320" /old_locus_tag="BSU11320" /experiment="publication(s) with functional evidences, PMID:16391061, 22171814, 27227299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16391061, 22171814, 27227299; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_389014.1" /db_xref="EnsemblGenomes-Gn:BSU11320" /db_xref="EnsemblGenomes-Tr:CAB12973" /db_xref="SubtiList:BG13222" /db_xref="UniProtKB/Swiss-Prot:O34891" /translation="MQLDVFSRMMFGDAAKPTEEKEEEQQEEVSQVSQTNDEETINYM HIMDQIGSIMNSLDQIKPALKELAPMLSAIKKKIM*" /label="yjzB CDS" gene complement(1132037..1132276) /gene="yjzB" /locus_tag="BSU_11320" /old_locus_tag="BSU11320" /label="yjzB gene" downshifts complement(1132053) /Source="Nicolas_upshifts" /id="D615" /incds=0 /nref=21 /ntot=48 /MaxReadThrough="1.43519" /MaxDrop="5.47891" /score="-7.75082002" /energy="-10.4" /TU="NA" /idTUdmin="U909" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1132289..1132308) /Source="Nicolas_upshift_promotors" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1132310) /Source="Nicolas_upshifts" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1132322..1132331) /Source="Nicolas_upshift_promotors" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1132337..1132344 /Source="Nicolas_upshift_promotors" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1132359..1132378 /Source="Nicolas_upshift_promotors" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1132373 /Source="Nicolas_upshifts" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="upshifts" CDS 1132441..1133379 /gene="fabHA" /locus_tag="BSU_11330" /old_locus_tag="BSU11330" /EC_number="2.3.1.180" /EC_number="2.3.1.38" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10629181, 11959561, 21542858, 25196128" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629181, 11959561, 21542858, 25196128; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase III 1" /protein_id="NP_389015.1" /db_xref="EnsemblGenomes-Gn:BSU11330" /db_xref="EnsemblGenomes-Tr:CAB12974" /db_xref="GOA:O34746" /db_xref="InterPro:IPR004655" /db_xref="InterPro:IPR013747" /db_xref="InterPro:IPR013751" /db_xref="InterPro:IPR016039" /db_xref="SubtiList:BG13127" /db_xref="UniProtKB/Swiss-Prot:O34746" /translation="MKAGILGVGRYIPEKVLTNHDLEKMVETSDEWIRTRTGIEERRI AADDVFSSHMAVAAAKNALEQAEVAAEDLDMILVATVTPDQSFPTVSCMIQEQLGAKK ACAMDISAACAGFMYGVVTGKQFIESGTYKHVLVVGVEKLSSITDWEDRNTAVLFGDG AGAAVVGPVSDDRGILSFELGADGTGGQHLYLNEKRHTIMNGREVFKFAVRQMGESCV NVIEKAGLSKEDVDFLIPHQANIRIMEAARERLELPVEKMSKTVHKYGNTSAASIPIS LVEELEAGKIKDGDVVVMVGFGGGLTWGAIAIRWGR*" /label="fabHA CDS" gene 1132441..1133379 /gene="fabHA" /locus_tag="BSU_11330" /old_locus_tag="BSU11330" /label="fabHA gene" promotor_-35 1132518..1132527 /Source="Nicolas_upshift_promotors" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1132536 /Source="Nicolas_upshifts" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1132539..1132554 /Source="Nicolas_upshift_promotors" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1133402..1134643 /gene="fabF" /locus_tag="BSU_11340" /old_locus_tag="BSU11340" /EC_number="2.3.1.41" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11325930, 12682299, 16436705, 18384517, 21542858, 28196402" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11325930, 12682299, 16436705, 18384517, 21542858, 28196402; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase II (involved in pimelate synthesis)" /protein_id="NP_389016.1" /db_xref="EnsemblGenomes-Gn:BSU11340" /db_xref="EnsemblGenomes-Tr:CAB12975" /db_xref="GOA:O34340" /db_xref="InterPro:IPR014030" /db_xref="InterPro:IPR014031" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR017568" /db_xref="InterPro:IPR018201" /db_xref="InterPro:IPR020841" /db_xref="PDB:4LS5" /db_xref="PDB:4LS6" /db_xref="PDB:4LS7" /db_xref="PDB:4LS8" /db_xref="SubtiList:BG13128" /db_xref="UniProtKB/Swiss-Prot:O34340" /translation="MTKKRVVVTGLGALSPLGNDVDTSWNNAINGVSGIGPITRVDAE EYPAKVAAELKDFNVEDYMDKKEARKMDRFTQYAVVAAKMAVEDADLNITDEIAPRVG VWVGSGIGGLETLESQFEIFLTKGPRRVSPFFVPMMIPDMATGQISIALGAKGVNSCT VTACATGTNSIGDAFKVIQRGDADVMVTGGTEAPLTRMSFAGFSANKALSTNPDPKTA SRPFDKNRDGFVMGEGAGIIVLEELEHALARGAKIYGEIVGYGSTGDAYHITAPAQDG EGGARAMQEAIKDAGIAPEEIDYINAHGTSTYYNDKYETMAIKTVFGEHAHKLAVSST KSMTGHLLGAAGGIEAIFSILAIKEGVIPPTINIQTPDEECDLDYVPDEARRQELNYV LSNSLGFGGHNATLIFKKYQS*" /label="fabF CDS" gene 1133402..1134643 /gene="fabF" /locus_tag="BSU_11340" /old_locus_tag="BSU11340" /label="fabF gene" promotor_-10 complement(1133616..1133634) /Source="Nicolas_upshift_promotors" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1133624) /Source="Nicolas_upshifts" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1133650..1133655) /Source="Nicolas_upshift_promotors" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1134494 /Source="Nicolas_upshifts" /id="D616" /incds=1 /nref=1 /ntot=89 /MaxReadThrough="7.03006" /MaxDrop="2.1101" /score="54.6350161" /energy="-18.5" /TU="U910,U911" /idTUdmin="U911" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts 1134627 /Source="Nicolas_upshifts" /id="D617" /incds=0 /nref=246 /ntot=274 /MaxReadThrough="0.58964" /MaxDrop="7.80446" /score="54.6350161" /energy="-18.5" /TU="NA" /idTUdmin="U911" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-35 1134668..1134677 /Source="Nicolas_upshift_promotors" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="promotor_-35" promotor_-10 1134690..1134709 /Source="Nicolas_upshift_promotors" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="promotor_-10" upshifts 1134692 /Source="Nicolas_upshifts" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="upshifts" promotor_-35 1134704..1134712 /Source="Nicolas_upshift_promotors" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1134719..1135504 /gene="yjaZ" /locus_tag="BSU_11350" /old_locus_tag="BSU11350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389017.1" /db_xref="EnsemblGenomes-Gn:BSU11350" /db_xref="EnsemblGenomes-Tr:CAB12992" /db_xref="InterPro:IPR018728" /db_xref="SubtiList:BG13129" /db_xref="UniProtKB/Swiss-Prot:O31596" /translation="MSVEQTYSWLRKAGSIDDLAHYIIPLFSGAEKKNWKGILGHLQH HGMFKNIKEGIQTVSKLKEKGFYGHIQKEEQYLKNKWQGPDVPIVTLPVDERNRRIRL EFGSKSGLAFQDKMFLFLSSDLDFGSVSALMTHEYHHVCRLGHLTKEEKDVTLLDTII MEGLAEYAVYERFGRSQTAEWTTWYTPEQLQALYEKKIAPHRDIKRDNRLFPQLLFGK GYQPKMLGYAVGFNIVKKYLTASKASTADGLSIPAETFLDAML*" /label="yjaZ CDS" gene 1134719..1135504 /gene="yjaZ" /locus_tag="BSU_11350" /old_locus_tag="BSU11350" /label="yjaZ gene" promotor_-10 1134724..1134742 /Source="Nicolas_upshift_promotors" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1134736 /Source="Nicolas_upshifts" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1135505..1135589 /Source="Nicolas_S_feature" /locus_tag="new_1211286_1211370" /HighExp="S6, S5, S8, S7, BT, S4, S3, B36, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S402" promotor_-10 complement(1135521..1135539) /Source="Nicolas_upshift_promotors" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1135538) /Source="Nicolas_upshifts" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1135554..1135559) /Source="Nicolas_upshift_promotors" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1135557..1135564 /Source="Nicolas_upshift_promotors" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1135579..1135598 /Source="Nicolas_upshift_promotors" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1135591..1135695 /Source="Nicolas_S_feature" /locus_tag="new_1211372_1211476" /HighExp="LoTm, T4.0H, T3.0H, T5.0H, T3.30H, T2.30H, M9-stat, S1, T2.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S403" upshifts 1135591 /Source="Nicolas_upshifts" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="upshifts" CDS 1135696..1136682 /gene="appD" /locus_tag="BSU_11360" /old_locus_tag="BSU11360" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 25755103, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 25755103, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389018.1" /db_xref="EnsemblGenomes-Gn:BSU11360" /db_xref="EnsemblGenomes-Tr:CAB12993" /db_xref="GOA:P42064" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11085" /db_xref="UniProtKB/Swiss-Prot:P42064" /translation="MSTLLEVNNLKTYFFRKKEPIPAVDGVDFHISKGETVALVGESG SGKSITSLSIMGLVQSSGGKIMDGSIKLEDKDLTSFTENDYCKIRGNEVSMIFQEPMT SLNPVLTIGEQITEVLIYHKNMKKKEARQRAVELLQMVGFSRAEQIMKEYPHRLSGGM RQRVMIAIALSCNPKLLIADEPTTALDVTIQAQVLELMKDLCQKFNTSILLITHDLGV VSEAADRVIVMYCGQVVENATVDDLFLEPLHPYTEGLLTSIPVIDGEIDKLNAIKGSV PTPDNLPPGCRFAPRCPKAMDKCWTNQPSLLTHKSGRTVRCFLYEEEGAEQS*" /label="appD CDS" gene 1135696..1136682 /gene="appD" /locus_tag="BSU_11360" /old_locus_tag="BSU11360" /label="appD gene" CDS 1136679..1137668 /gene="appF" /locus_tag="BSU_11370" /old_locus_tag="BSU11370" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 25755103, 26728191, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 25755103, 26728191, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389019.2" /db_xref="EnsemblGenomes-Gn:BSU11370" /db_xref="EnsemblGenomes-Tr:CAB12994" /db_xref="GOA:P42065" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11086" /db_xref="UniProtKB/Swiss-Prot:P42065" /translation="MTAANQETILELRDVKKYFPIRSGLFQRKVGDVKAVDGVSFSLK KGETLGIVGESGCGKSTAGRTMIRLYKPTEGQILFKGQDISNLSEEKLRKSVRKNIQM VFQDPFASLNPRKTLRSIIKEPFNTHNMYTMRERNEKVEELLARVGLHPSFAGRYPHE FSGGQRQRIGIARALTLNPELIIADEPVSALDVSIQAQVINLMEELQEEFNLTYLFIS HDLSVVRHISDRVGVMYLGKMMELTGKHELYDNPLHPYTQALLSSVPVTRKRGSVKRE RIVLKGELPSPANPPKGCVFHTRCPVAKPICKEQIPEFKEAAPSHFVACHLYS*" /label="appF CDS" gene 1136679..1137668 /gene="appF" /locus_tag="BSU_11370" /old_locus_tag="BSU11370" /label="appF gene" misc_feature 1137674..1137680 /Source="Nicolas_upshift_promotors" /id="U917" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.062937062937063" /xcortree=2877 /SigmaFactorBS="ttaaagaagctgctcccagccactttgtggcttgtcaccttt atagctaatgttgCCCGCACagctttgagagggggtatgcacactacataaacaacag c" /listShort="S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1137679..1137755 /Source="Nicolas_S_feature" /locus_tag="new_1213460_1213536" /HighExp="T2.0H, S1, M9-stat, T5.0H, T3.0H, T1.30H, S2, M0t90, T2.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.0629, 0.999" /TUlongSig="SigK" /TUlongPSig=1 /label="S404" upshifts 1137679 /Source="Nicolas_upshifts" /id="U917" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.062937062937063" /xcortree=2877 /SigmaFactorBS="ttaaagaagctgctcccagccactttgtggcttgtcaccttt atagctaatgttgCCCGCACagctttgagagggggtatgcacactacataaacaacag c" /listShort="S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="upshifts" CDS 1137756..1138247 /gene="appAn" /locus_tag="BSU_11381" /old_locus_tag="BSU11381" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 15588833, 25355936; Product type rc: receptor" /pseudo /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (oligopeptide-binding lipoprotein); N-terminal part of AppA" /translation="MKRRKTALMMLSVLMVLAIFLSACSGSKSSNSSAKKSAGKPQQG GDLVVGSIGEPTLFNSLYSTDDASTDIENMLYSFLTKTDEKLNVKLSLAESIKELDGG LAYDVKIKKGVKFHDGKELTADDVVFTYSVPLSKDYKGERGSTYEMLKSVEKKAITKS CLS*" /label="appAn CDS" gene 1137756..1138247 /gene="appAn" /locus_tag="BSU_11381" /old_locus_tag="BSU11381" /pseudo /label="appAn gene" CDS 1138220..1139386 /gene="appAc" /locus_tag="BSU_11382" /old_locus_tag="BSU11382" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7997159, 15588833, 26728191; Product type lp: lipoprotein" /pseudo /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (oligopeptide-binding lipoprotein); C-terminal part of AppA" /translation="GDYEVLFKLKYKDGNFYNNALDSTAILPKHILGNVPIADLEENE FNRKKPIGSGPFKFKEWKQGQYIKLEANDDYFEGRPYLDTVTYKVIPDANAAVAQLQA GDINFFNVPATDYKTAEKFNNLKIVTDLALSYVYIGWNEKNELFKDKKVRQALTTALD RESIVSQVLDGDGEVAYIPESPLSWNYPKDIDVPKFEYNEKKAKQMLAEAGWKDTNGD GILDKDGKKFSFTLKTNQGNKVREDIAVVVQEQLKKIGIEVKTQIVEWSALVEQMNPP NWDFDAMVMGWSLSTFPDQYDIFHSSQIKKGLNYVWYKNAEADKLMKDAKSISDRKQY SKEYEQIYQKIAEDQPYTFLYYPNNHMAMPENLEGYKYHPKRDLYNIEKWWLAK*" /label="appAc CDS" gene 1138220..1139386 /gene="appAc" /locus_tag="BSU_11382" /old_locus_tag="BSU11382" /pseudo /label="appAc gene" downshifts 1139377 /Source="Nicolas_upshifts" /id="D618" /incds=0 /nref=1 /ntot=49 /MaxReadThrough="7.71397" /MaxDrop="3.11667" /score="-1.00317393" /energy="-13.3" /TU="U916,U917" /idTUdmin="U913" /TUdmin=1715 /isTUend="FALSE" /label="downshifts" CDS 1139462..1140412 /gene="appB" /locus_tag="BSU_11390" /old_locus_tag="BSU11390" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 15849754, 16850406, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 15849754, 16850406, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389021.2" /db_xref="EnsemblGenomes-Gn:BSU11390" /db_xref="EnsemblGenomes-Tr:CAB12996" /db_xref="GOA:P42062" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11088" /db_xref="UniProtKB/Swiss-Prot:P42062" /translation="MAAYIIRRTLMSIPILLGITILSFVIMKAAPGDPMTLMMDPKIS QADREQFIEKYGLNDPQYVQYLKWLGNMVQGDFGTSIVRKGTPVSELIMARLPNTLLL MLVSTILALMISIPFGVLSAKRPYSKIDYGITFTSFIGLAIPNFWFGLILIMVLSVNL GWFPTGGVETLNTEFNIFDRIHHLILPAFVLATADMAGLTRYTRSNMLDVLNQDYIRT ARAKGFKENRVLFKHGLRNALLPVITIFGLMIPSFIGGSVVVEQIFTWPGLGKLFVDS AFQRDYPVIMAMTVISAVLVVVGNLIADILYAIVDPRIEY*" /label="appB CDS" gene 1139462..1140412 /gene="appB" /locus_tag="BSU_11390" /old_locus_tag="BSU11390" /label="appB gene" CDS 1140429..1141340 /gene="appC" /locus_tag="BSU_11400" /old_locus_tag="BSU11400" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 15849754, 16850406, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 15849754, 16850406, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389022.1" /db_xref="EnsemblGenomes-Gn:BSU11400" /db_xref="EnsemblGenomes-Tr:CAB12997" /db_xref="GOA:P42063" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11089" /db_xref="UniProtKB/Swiss-Prot:P42063" /translation="MSELQTTPSPEIRLKENISKKPETMTKIFWEKFSKNKLAILGAV ILFIIIMSAVFAPLIAPYPQEQQSLLDKYKAPGLEHLMGTDKFGRDIFSRILYGARVS LLVGFASVVGSILIGTVLGALAGYFRGIVDAVIMRVVDIVLSIPDIFLLITLVTIFKP GVDKLILIFCLTGWTTTARLVRGEFLSLRSREYVLAAKTIGTKTHKIIFSHILPNALG PIIVSATLKVGSVILAESALSYLGFGIQPPIASWGNMLQDAQNFTVMIQAWWYPLFPG LFILMTVLCFNFVGDGLRDALDPKNIK*" /label="appC CDS" gene 1140429..1141340 /gene="appC" /locus_tag="BSU_11400" /old_locus_tag="BSU11400" /label="appC gene" downshifts 1141354 /Source="Nicolas_upshifts" /id="D619" /incds=0 /nref=62 /ntot=188 /MaxReadThrough="5.13927" /MaxDrop="5.50153" /score="22.0028545" /energy="-11.6" /TU="U916,U917" /idTUdmin="U916" /TUdmin="-923" /isTUend="FALSE" /label="downshifts" S_feature 1141399..1141506 /Source="Nicolas_S_feature" /locus_tag="new_1217180_1217287" /HighExp="LoTm, S1, S2, BT, T3.30H, T4.0H, T5.0H, T3.0H, Glu, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.0629, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S405" promotor_-35 1141479..1141484 /Source="Nicolas_upshift_promotors" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1141500..1141518 /Source="Nicolas_upshift_promotors" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1141508 /Source="Nicolas_upshifts" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="upshifts" CDS 1141545..1142297 /gene="yjbA" /locus_tag="BSU_11410" /old_locus_tag="BSU11410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717292, 22882546; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation nucleic acid binding protein" /protein_id="NP_389023.1" /db_xref="EnsemblGenomes-Gn:BSU11410" /db_xref="EnsemblGenomes-Tr:CAB12998" /db_xref="InterPro:IPR020909" /db_xref="SubtiList:BG13130" /db_xref="UniProtKB/Swiss-Prot:O31597" /translation="MLFLHDVWVNWFEGEENGYNVCHFHEWRKEDTVELLDQVPLLRV PSVLFHYIENDLSELPKGLLEDVHQKSYIRKNHERTKLEYCFVVTDGIGILAVDTIGY TIPVRKSRLIPRQEQLVYEMVKDVEPETYEFEPKKLESSKEYHILSLAPEHVRGLTRK ERQIKQLMFMALDQLKGLKNRAEIGYWYTEWNPHMYEQIKRMSFEEIWDMLYNETIEG WSDKHLAFCENLIKGQPFFEKLWEMENESKVN*" /label="yjbA CDS" gene 1141545..1142297 /gene="yjbA" /locus_tag="BSU_11410" /old_locus_tag="BSU11410" /label="yjbA gene" downshifts 1142277 /Source="Nicolas_upshifts" /id="D620" /incds=0 /nref=32 /ntot=112 /MaxReadThrough="1.07428" /MaxDrop="6.2264" /score="22.0028545" /energy="-11.6" /TU="NA" /idTUdmin="U916" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1142332..1143324) /gene="trpS" /locus_tag="BSU_11420" /old_locus_tag="BSU11420" /EC_number="6.1.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8950174, 10706627, 12682299, 24572018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8950174, 10706627, 12682299, 24572018; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tryptophanyl-tRNA synthetase" /protein_id="NP_389024.1" /db_xref="EnsemblGenomes-Gn:BSU11420" /db_xref="EnsemblGenomes-Tr:CAB12999" /db_xref="GOA:P21656" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002306" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024109" /db_xref="PDB:3PRH" /db_xref="SubtiList:BG10799" /db_xref="UniProtKB/Swiss-Prot:P21656" /translation="MKQTIFSGIQPSGSVTLGNYIGAMKQFVELQHDYNSYFCIVDQH AITVPQDRLELRKNIRNLAALYLAVGLDPEKATLFIQSEVPAHAQAGWMMQCVAYIGE LERMTQFKDKSKGNEAVVSGLLTYPPLMAADILLYGTDLVPVGEDQKQHLELTRNLAE RFNKKYNDIFTIPEVKIPKVGARIMSLNDPLKKMSKSDPNQKAYITLLDEPKQLEKKI KSAVTDSEGIVKFDKENKPGVSNLLTIYSILGNTTIEELEAKYEGKGYGEFKGDLAEV VVNALKPIQDRYYELIESEELDRILDEGAERANRTANKMLKKMENAMGLGRKRR*" /label="trpS CDS" gene complement(1142332..1143324) /gene="trpS" /locus_tag="BSU_11420" /old_locus_tag="BSU11420" /label="trpS gene" downshifts complement(1142353) /Source="Nicolas_upshifts" /id="D621" /incds=0 /nref=224 /ntot=255 /MaxReadThrough="1.77115" /MaxDrop="6.72647" /score="27.6275522" /energy="-11.6" /TU="U919" /idTUdmin="U919" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" misc_RNA complement(1143383..1143597) /gene="tboWA" /locus_tag="BSU_misc_RNA_13" /product="T-box riboswitch specific of tryptophan tRNA" /experiment="publication(s) with functional evidences, PMID:8045882, 9098041, 10706627, 10943892, 11842119, 12165569, 12547201, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 9098041, 10706627, 10943892, 11842119, 12165569, 12547201, 1317842; Product type n: RNA" /function="16.3: Control" /label="tboWA RNA" gene complement(1143383..1143597) /gene="tboWA" /locus_tag="BSU_misc_RNA_13" /label="tboWA gene" downshifts complement(1143431) /Source="Nicolas_upshifts" /id="D622" /incds=0 /nref=37 /ntot=127 /MaxReadThrough="6.8472" /MaxDrop="5.13001" /score="25.1445248" /energy="-19" /TU="U919" /idTUdmin="U919" /TUdmin="-1100" /isTUend="FALSE" /label="downshifts" misc_feature complement(1143616..1143635) /Source="Nicolas_upshift_promotors" /id="U919" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.509490509490509" /psig="0.99100899100899" /xcortree=602 /SigmaFactorBS="tatttatattattacaattttactggaaaaaagaatgttttt tcatgatgacaaTTGGTTATAATTGATTTATAatgaagcaatcaaaagaaaagcttgc t" /listShort="NA, trpS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1143629) /Source="Nicolas_upshifts" /id="U919" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.509490509490509" /psig="0.99100899100899" /xcortree=602 /SigmaFactorBS="tatttatattattacaattttactggaaaaaagaatgttttt tcatgatgacaaTTGGTTATAATTGATTTATAatgaagcaatcaaaagaaaagcttgc t" /listShort="NA, trpS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1143884..1143891 /Source="Nicolas_upshift_promotors" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1143905..1144067 /Source="Nicolas_S_feature" /locus_tag="new_1219686_1219848" /HighExp="S1, T3.0H, T3.30H, T2.30H, T4.0H, T5.0H, LoTm, T2.0H, M40t90, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S406" promotor_-10 1143906..1143925 /Source="Nicolas_upshift_promotors" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1143906 /Source="Nicolas_upshifts" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="upshifts" CDS 1144068..1145705 /gene="oppA" /locus_tag="BSU_11430" /old_locus_tag="BSU11430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11083832, 11401703, 12823818, 15588833, 23133654, 26176322, 22720735, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11083832, 11401703, 12823818, 15588833, 23133654, 26176322, 22720735, 25355936; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (binding lipoprotein)" /protein_id="NP_389025.1" /db_xref="EnsemblGenomes-Gn:BSU11430" /db_xref="EnsemblGenomes-Tr:CAB13000" /db_xref="GOA:P24141" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR023765" /db_xref="InterPro:IPR030678" /db_xref="SubtiList:BG10771" /db_xref="UniProtKB/Swiss-Prot:P24141" /translation="MKKRWSIVTLMLIFTLVLSACGFGGSGSNGEGKKDSKGKTTLNI NIKTEPFSLHPGLANDSVSGGVIRQTFEGLTRINADGEPEEGMASKIETSKDGKTYTF TIRDGVKWSNGDPVTAQDFEYAWKWALDPNNESQYAYQLYYIKGAEAANTGKGSLDDV AVKAVNDKTLKVELNNPTPYFTELTAFYTYMPINKKIAEKNKKWNTNAGDDYVSNGPF KMTAWKHSGSITLEKNDQYWDKDKVKLKKIDMVMINNNNTELKKFQAGELDWAGMPLG QLPTESLPTLKKDGSLHVEPIAGVYWYKFNTEAKPLDNVNIRKALTYSLDRQSIVKNV TQGEQIPAMAAVPPTMKGFEDNKEGYFKDNDVKTAKEYLEKGLKEMGLSKASDLPKIK LSYNTDDAHAKIAQAVQEMWKKNLGVDVELDNSEWNVYIDKLHSQDYQIGRMGWLGDF NDPINFLELFRDKNGGNNDTGWENPEFKKLLNQSQTETDKTKRAELLKKAEGIFIDEM PVAPIYFYTDTWVQDENLKGVIMPGTGEVYFRNAYFK*" /label="oppA CDS" gene 1144068..1145705 /gene="oppA" /locus_tag="BSU_11430" /old_locus_tag="BSU11430" /label="oppA gene" downshifts 1145599 /Source="Nicolas_upshifts" /id="D623" /incds=1 /nref=8 /ntot=166 /MaxReadThrough="6.94127" /MaxDrop="3.3677" /score="-4.2761508" /energy="-15.6" /TU="U920" /idTUdmin="U916" /TUdmin=3322 /isTUend="FALSE" /label="downshifts" S_feature 1145706..1145812 /Source="Nicolas_S_feature" /locus_tag="new_1221487_1221593" /HighExp="S1, LoTm, T4.0H, BT, T3.30H, T3.0H, T5.0H, M0t90, T2.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S407" CDS 1145813..1146748 /gene="oppB" /locus_tag="BSU_11440" /old_locus_tag="BSU11440" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 15849754, 16850406, 17600541, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 15849754, 16850406, 17600541, 25355936; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389026.1" /db_xref="EnsemblGenomes-Gn:BSU11440" /db_xref="EnsemblGenomes-Tr:CAB13001" /db_xref="GOA:P24138" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10772" /db_xref="UniProtKB/Swiss-Prot:P24138" /translation="MLKYIGRRLVYMIITLFVIVTVTFFLMQAAPGGPFSGEKKLPPE IEANLNAHYGLDKPLFVQYVSYLKSVAMWDFGPSFKYKGQSVNDLISSGFPVSFTLGA EAILLALALGVLFGVIAALYHNKWQDYTVAILTIFGISVPSFIMAAVLQYVFSMKLGL FPVAGWDSWAYTFLPSIALASMPMAFIARLSRSSMIEVLNSDYIRTAKAKGLSRPAVT VRHAIRNALLPVVTYMGPMAAQVLTGSFIIETIFGIPGLGAHFVNSITNRDYTVIMGV TVFFSVILLLCVLIVDVLYGIIDPRIKLSKAKKGA*" /label="oppB CDS" gene 1145813..1146748 /gene="oppB" /locus_tag="BSU_11440" /old_locus_tag="BSU11440" /label="oppB gene" promotor_-10 complement(1145856..1145875) /Source="Nicolas_upshift_promotors" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1145873) /Source="Nicolas_upshifts" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1145891..1145897) /Source="Nicolas_upshift_promotors" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1146752..1147669 /gene="oppC" /locus_tag="BSU_11450" /old_locus_tag="BSU11450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 15849754, 16850406, 26782429" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 15849754, 16850406, 26782429; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389027.1" /db_xref="EnsemblGenomes-Gn:BSU11450" /db_xref="EnsemblGenomes-Tr:CAB13002" /db_xref="GOA:P24139" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10773" /db_xref="UniProtKB/Swiss-Prot:P24139" /translation="MQNIPKNMFEPAAANAGDAEKISKKSLSLWKDAMLRFRSNKLAM VGLIIIVLIILMAIFAPMFSRYDYSTTNLLNADKPPSKDHWFGTDDLGRDIFVRTWVG ARISIFIGVAAAVLDLLIGVIWGSISGFRGGRTDEIMMRIADILWAVPSLLMVILLMV VLPKGLFTIIIAMTITGWINMARIVRGQVLQLKNQEYVLASQTLGAKTSRLLFKHIVP NAMGSILVTMTLTVPTAIFTEAFLSYLGLGVPAPLASWGTMASDGLPALTYYPWRLFF PAGFICITMFGFNVVGDGLRDALDPKLRK*" /label="oppC CDS" gene 1146752..1147669 /gene="oppC" /locus_tag="BSU_11450" /old_locus_tag="BSU11450" /label="oppC gene" CDS 1147674..1148750 /gene="oppD" /locus_tag="BSU_11460" /old_locus_tag="BSU11460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 19202088, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 19202088, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389028.1" /db_xref="EnsemblGenomes-Gn:BSU11460" /db_xref="EnsemblGenomes-Tr:CAB13003" /db_xref="GOA:P24136" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10774" /db_xref="UniProtKB/Swiss-Prot:P24136" /translation="MIRVTRLLEVKDLAISFKTYGGEVQAIRGVNFHLDKGETLAIVG ESGSGKSVTSQAIMKLIPMPPGYFKRGEILFEGKDLVPLSEKEMQNVRGKEIGMIFQD PMTSLNPTMKVGKQITEVLFKHEKISKEAAKKRAVELLELVGIPMPEKRVNQFPHEFS GGMRQRVVIAMALAANPKLLIADEPTTALDVTIQAQILELMKDLQKKIDTSIIFITHD LGVVANVADRVAVMYAGQIVETGTVDEIFYDPRHPYTWGLLASMPTLESSGEEELTAI PGTPPDLTNPPKGDAFALRSSYAMKIDFEQEPPMFKVSDTHYVKSWLLHPDAPKVEPP EAVKAKMRKLANTFEKPVLVREVE*" /label="oppD CDS" gene 1147674..1148750 /gene="oppD" /locus_tag="BSU_11460" /old_locus_tag="BSU11460" /label="oppD gene" CDS 1148752..1149669 /gene="oppF" /locus_tag="BSU_11470" /old_locus_tag="BSU11470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 7997159, 11401703, 23133654, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 7997159, 11401703, 23133654, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389029.1" /db_xref="EnsemblGenomes-Gn:BSU11470" /db_xref="EnsemblGenomes-Tr:CAB13004" /db_xref="GOA:P24137" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10775" /db_xref="UniProtKB/Swiss-Prot:P24137" /translation="MTEKLLEIKHLKQHFVTPRGTVKAVDDLSFDIYKGETLGLVGES GCGKSTTGRSIIRLYEATDGEVLFNGENVHGRKSRKKLLEFNRKMQMIFQDPYASLNP RMTVADIIAEGLDIHKLAKTKKERMQRVHELLETVGLNKEHANRYPHEFSGGQRQRIG IARALAVDPEFIIADEPISALDVSIQAQVVNLMKELQKEKGLTYLFIAHDLSMVKYIS DRIGVMYFGKLVELAPADELYENPLHPYTKSLLSAIPLPDPDYERNRVRQKYDPSVHQ LKDGETMEFREVKPGHFVMCTEAEFKAFS*" /label="oppF CDS" gene 1148752..1149669 /gene="oppF" /locus_tag="BSU_11470" /old_locus_tag="BSU11470" /label="oppF gene" downshifts 1149639 /Source="Nicolas_upshifts" /id="D624" /incds=0 /nref=21 /ntot=196 /MaxReadThrough="1.58906" /MaxDrop="5.17491" /score="28.2861081" /energy="-15.2" /TU="NA" /idTUdmin="U920" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 1149719..1149722 /Source="Nicolas_upshift_promotors" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1149735 /Source="Nicolas_upshifts" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1149737..1149756 /Source="Nicolas_upshift_promotors" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1149776..1150993 /gene="yjbB" /locus_tag="BSU_11480" /old_locus_tag="BSU11480" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563878, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter" /protein_id="NP_389030.2" /db_xref="EnsemblGenomes-Gn:BSU11480" /db_xref="EnsemblGenomes-Tr:CAB13005" /db_xref="GOA:O31600" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13131" /db_xref="UniProtKB/Swiss-Prot:O31600" /translation="MQFLHNKNVFALLLSQSFQSLAGVLVTIVLMVRIYQMTDSVFLA GLILSFMSFASIAASFCVSPVLRILGFKKVLAGANLLRAVFIILMAYSVTHHGQAFFW ITLLFVFCFSFAGAFFQPARFALLPIIVPKKQYVKANGVISLSNQLFLTAGWGLGGLL TYAVPFELVVGAAICLFVLSGASISVLHVNEEEAAGTAETASVRSIWKDLMIIPIVRD ITVMDMLEALAGSVWSSAILLAFTAAVLHETEVWWGMFNASYFIGAIVGSVIAIRFSS FFERNMGYAIMFSSLVMSALTLLFSFSPVPFLCALACAAMGPFYQVRDICQETMLQEV IPEQKRIGIMAAKNAILTPWSGVTYSIMGLVADAAGAKIAFIAAAALYIMTFLIALAQ PRLVHYRRENRVQ*" /label="yjbB CDS" gene 1149776..1150993 /gene="yjbB" /locus_tag="BSU_11480" /old_locus_tag="BSU11480" /label="yjbB gene" promotor_-35 1151046..1151055 /Source="Nicolas_upshift_promotors" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="promotor_-35" promotor_-10 1151068..1151083 /Source="Nicolas_upshift_promotors" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="promotor_-10" S_feature 1151077..1151156 /Source="Nicolas_S_feature" /locus_tag="new_1226858_1226937" /HighExp="Etha, B60, M9-stat, T0.30H, Salt, T3.0H, T1.0H, T4.0H, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S408" upshifts 1151077 /Source="Nicolas_upshifts" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="upshifts" CDS 1151157..1151735 /gene="yjbC" /locus_tag="BSU_11490" /old_locus_tag="BSU11490" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17158660, 17158663, 21815947; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol oxidation management factor; putative acetyltransferase" /protein_id="NP_389031.2" /db_xref="EnsemblGenomes-Gn:BSU11490" /db_xref="EnsemblGenomes-Tr:CAB13006" /db_xref="GOA:O31601" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13132" /db_xref="UniProtKB/Swiss-Prot:O31601" /translation="MNWYEKLSEYFPIEEMKSKAHMEALLKERSDIYHKDEGKHHILM FAEFDSFIFVDYLYVSKDARGQGLGGKLIAKLKKKNKPILLEVEPVDEDDTDTEKRLR FYQREHFKHAQSIGYRRRSLATNEVNKMEILYWSPKTESEEEILEAMKQTYENIHTYK DEKWYGESYEKTDEVLEIIDEEKQKNIFDQLS*" /label="yjbC CDS" gene 1151157..1151735 /gene="yjbC" /locus_tag="BSU_11490" /old_locus_tag="BSU11490" /label="yjbC gene" S_feature 1151736..1151850 /Source="Nicolas_S_feature" /locus_tag="new_1227517_1227631" /HighExp="B60, Etha, Salt, T0.30H, M9-stat, LoTm, Gly, T1.0H, B36, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S409" promotor_-10 complement(1151787..1151806) /Source="Nicolas_upshift_promotors" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1151791) /Source="Nicolas_upshifts" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1151820..1151827) /Source="Nicolas_upshift_promotors" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1151853..1151866 /Source="Nicolas_upshift_promotors" /id="U925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.815184815184815" /psig="0.973026973026973" /xcortree=1536 /SigmaFactorBS="cttaggatactgttcacacttacttttttatagtataatacc tgtaaagattccttttttAGAGTAATTTCAATttaagaataaaatagatgttcatcct a" /listShort="spxA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1151853 /Source="Nicolas_upshifts" /id="U925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.815184815184815" /psig="0.973026973026973" /xcortree=1536 /SigmaFactorBS="cttaggatactgttcacacttacttttttatagtataatacc tgtaaagattccttttttAGAGTAATTTCAATttaagaataaaatagatgttcatcct a" /listShort="spxA" /GFF_Attribute="listLong" /label="upshifts" CDS 1151916..1152311 /gene="spxA" /locus_tag="BSU_11500" /old_locus_tag="BSU11500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12642660, 14597697, 15659166, 16249335, 16740936, 18662407, 22307755, 23894131, 28484046, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12642660, 14597697, 15659166, 16249335, 16740936, 18662407, 22307755, 23894131, 28484046, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="redox-sensitive regulator" /protein_id="NP_389032.1" /db_xref="EnsemblGenomes-Gn:BSU11500" /db_xref="EnsemblGenomes-Tr:CAB13007" /db_xref="GOA:O31602" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR023731" /db_xref="InterPro:IPR036249" /db_xref="PDB:1Z3E" /db_xref="PDB:3GFK" /db_xref="PDB:3IHQ" /db_xref="SubtiList:BG13133" /db_xref="UniProtKB/Swiss-Prot:O31602" /translation="MVTLYTSPSCTSCRKARAWLEEHEIPFVERNIFSEPLSIDEIKQ ILRMTEDGTDEIISTRSKVFQKLNVNVESMPLQDLYRLINEHPGLLRRPIIIDEKRLQ VGYNEDEIRRFLPRKVRSFQLREAQRLAN*" /label="spxA CDS" gene 1151916..1152311 /gene="spxA" /locus_tag="BSU_11500" /old_locus_tag="BSU11500" /label="spxA gene" promotor_no_box complement(1152147..1152247) /Source="Nicolas_upshift_promotors" /id="U926" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.000999000999001" /xcortree=57 /SigmaFactorBS="ctgatttcgtcttcgttatatccgacctgcaaacgtttttcg tcaatgatgatcggacggcgaagcaaacctggatgctcgttgatcaagcggtacaaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1152187) /Source="Nicolas_upshifts" /id="U926" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.000999000999001" /xcortree=57 /SigmaFactorBS="ctgatttcgtcttcgttatatccgacctgcaaacgtttttcg tcaatgatgatcggacggcgaagcaaacctggatgctcgttgatcaagcggtacaaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1152309 /Source="Nicolas_upshifts" /id="D625" /incds=0 /nref=263 /ntot=269 /MaxReadThrough="4.34531" /MaxDrop="8.0579" /score="7.42972561" /energy="-8.8" /TU="U923" /idTUdmin="U925" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1152354..1153143 /Source="Nicolas_S_feature" /locus_tag="new_1228135_1228924" /HighExp="B60, B36, Etha, M9-stat, Salt, H2O2, Paraq, Cold, G180, G135" /AntisenseName="yjbE" /AntisenseCor="-0.18634010398760401" /AntisenseRegPval="-2.7" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S410" CDS complement(1152354..1153010) /gene="yjbE" /locus_tag="BSU_11510" /old_locus_tag="BSU11510" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_389033.1" /db_xref="EnsemblGenomes-Gn:BSU11510" /db_xref="EnsemblGenomes-Tr:CAB13008" /db_xref="GOA:O31603" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022301" /db_xref="SubtiList:BG13134" /db_xref="UniProtKB/Swiss-Prot:O31603" /translation="MEHDYLISLLVIVGIDLILGGDNAVVIAMASRHLPDKQRQQAII LGTFIAVAMRIGLTSAAVYLLNIPFLQCAGGIFLLYLGYQLLIEKKDTKHIKSSTSLW RAIRTIVLADLFMSLDNVIAVAGASHGEFSLVVIGLCVSVPVIIWGSKLIHIALEKIP LLIYAGSGLLAYTGGEMIVRDKKLSLFMAQHGTVETLLPILTVAFVILASIYYQQVEK *" /label="yjbE CDS" gene complement(1152354..1153010) /gene="yjbE" /locus_tag="BSU_11510" /old_locus_tag="BSU11510" /label="yjbE gene" promotor_-10 complement(1153040..1153058) /Source="Nicolas_upshift_promotors" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1153055) /Source="Nicolas_upshifts" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1153073..1153078) /Source="Nicolas_upshift_promotors" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1153116..1153123 /Source="Nicolas_upshift_promotors" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1153137..1153156 /Source="Nicolas_upshift_promotors" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1153145..1153286 /Source="Nicolas_S_feature" /locus_tag="new_1228926_1229067" /HighExp="B60, Diami, Etha, dia5, LPhT, M9-stat, T5.0H, T3.0H, dia15, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S411" upshifts 1153145 /Source="Nicolas_upshifts" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="upshifts" CDS 1153180..1153320 /locus_tag="BSU_11515" /old_locus_tag="BSU11515" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513949.1" /translation="MVKVKMWTEWVKCSKVQLIGSLDVPSTSYIEGKVGKWKLKELTS IQ*" /label="conserved hypothetical protein CDS" gene 1153180..1153320 /locus_tag="BSU_11515" /old_locus_tag="BSU11515" /label="gene" CDS 1153287..1153943 /gene="mecA" /locus_tag="BSU_11520" /old_locus_tag="BSU11520" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10361283, 10447896, 16525504, 19801546, 21435029, 23595989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10361283, 10447896, 16525504, 19801546, 21435029, 23595989; Product type f : factor" /codon_start=1 /transl_table=11 /product="adaptor protein controlling oligomerization of the AAA+ protein ClpC" /protein_id="NP_389034.1" /db_xref="EnsemblGenomes-Gn:BSU11520" /db_xref="EnsemblGenomes-Tr:CAB13009" /db_xref="GOA:P37958" /db_xref="InterPro:IPR008681" /db_xref="PDB:2Y1R" /db_xref="PDB:3J3R" /db_xref="PDB:3J3S" /db_xref="PDB:3J3T" /db_xref="PDB:3J3U" /db_xref="PDB:3JTP" /db_xref="PDB:3PXG" /db_xref="PDB:3PXI" /db_xref="SubtiList:BG10680" /db_xref="UniProtKB/Swiss-Prot:P37958" /translation="MEIERINEHTVKFYMSYGDIEDRGFDREEIWYNRERSEELFWEV MDEVHEEEEFAVEGPLWIQVQALDKGLEIIVTKAQLSKDGQKLELPIPEDKKQEPASE DLDALLDDFQKEEQAVNQEEKEQKLQFVLRFGDFEDVISLSKLNVNGSKTTLYSFENR YYLYVDFCNMTDEEVENQLSILLEYATESSISIHRLEEYGKLIISEHALETIKKHFAS *" /label="mecA CDS" gene 1153287..1153943 /gene="mecA" /locus_tag="BSU_11520" /old_locus_tag="BSU11520" /label="mecA gene" downshifts 1153933 /Source="Nicolas_upshifts" /id="D626" /incds=0 /nref=120 /ntot=308 /MaxReadThrough="5.41786" /MaxDrop="7.67172" /score="32.2431225" /energy="-11.8" /TU="U928" /idTUdmin="U928" /TUdmin="-774" /isTUend="FALSE" /label="downshifts" CDS complement(1153938..1154060) /locus_tag="BSU_11525" /old_locus_tag="BSU11525" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513950.1" /translation="MINSCSLYFLLVYMFLIFHISKMAFSCIKKTDFRKEIGLL*" /label="conserved hypothetical protein CDS" gene complement(1153938..1154060) /locus_tag="BSU_11525" /old_locus_tag="BSU11525" /label="gene" S_feature 1153978..1154067 /Source="Nicolas_S_feature" /locus_tag="new_1229759_1229848" /HighExp="Etha, M9-stat, B60, dia15, T0.30H, Diami, C30, H2O2, dia5, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S412" promotor_-35 1154046..1154054 /Source="Nicolas_upshift_promotors" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1154065..1154083 /Source="Nicolas_upshift_promotors" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1154069..1154133 /Source="Nicolas_S_feature" /locus_tag="new_1229850_1229914" /HighExp="Etha, G/S, GM 150, T-4.40H, S2, T-2.40H, Pyr, C90, M9-tran, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.876, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S413" upshifts 1154069 /Source="Nicolas_upshifts" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="upshifts" CDS 1154134..1155255 /gene="coiA" /locus_tag="BSU_11530" /old_locus_tag="BSU11530" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10438773, 17630974, 23046409, 26880300" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438773, 17630974, 23046409, 26880300; Product type s: structure" /codon_start=1 /transl_table=11 /product="protein involved in establishment of DNA transport in competence" /protein_id="NP_389035.1" /db_xref="EnsemblGenomes-Gn:BSU11530" /db_xref="EnsemblGenomes-Tr:CAB13010" /db_xref="GOA:O31604" /db_xref="InterPro:IPR010330" /db_xref="InterPro:IPR021176" /db_xref="SubtiList:BG13135" /db_xref="UniProtKB/Swiss-Prot:O31604" /translation="MFHLLGAQQNQKLKRRRFFCPVCGGELAVKLGLQKAPHFAHKQN KSCAIDIEPESAYHLEGKRQLYVWLKTQRASPILEPYIRTINQRPDVMARIKEHMLAV EYQCATIAPDVFQKRTEGFKQEGIIPQWIMGYSRLKRTASSFYQLSTFHWQFINASPY RELICYCPERRSFLRLSHIIPFYTNHSYSSVQTIPIHRAGAGDLFFTEPKPSIQYSGW TKAIHRFRHKPHRFNSKETNRLRLLFYEKRQTPFSFLPTEVFVPVRKGAVFKSPVFVW QGFLYLFMTDLGGKRAPIRFSAVLQQCKLHIHNKNIALRSECSEECLSEAVKQYIDFL CKKGFLRETQKEVYVLNQPAGGIHSMQDLIERDRSCFIE*" /label="coiA CDS" gene 1154134..1155255 /gene="coiA" /locus_tag="BSU_11530" /old_locus_tag="BSU11530" /label="coiA gene" promotor_-35 1154909..1154915 /Source="Nicolas_upshift_promotors" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="promotor_-35" upshifts 1154927 /Source="Nicolas_upshifts" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="upshifts" promotor_-10 1154930..1154948 /Source="Nicolas_upshift_promotors" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="promotor_-10" promotor_-35 1155141..1155149 /Source="Nicolas_upshift_promotors" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="promotor_-35" promotor_-10 1155161..1155179 /Source="Nicolas_upshift_promotors" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="promotor_-10" upshifts 1155168 /Source="Nicolas_upshifts" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="upshifts" promotor_-35 1155249..1155255 /Source="Nicolas_upshift_promotors" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1155270..1155281 /Source="Nicolas_upshift_promotors" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1155279 /Source="Nicolas_upshifts" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="upshifts" CDS 1155302..1157314 /gene="pepF" /locus_tag="BSU_11540" /old_locus_tag="BSU11540" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11741842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11741842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligoendopeptidase F" /protein_id="NP_389036.2" /db_xref="EnsemblGenomes-Gn:BSU11540" /db_xref="EnsemblGenomes-Tr:CAB13011" /db_xref="GOA:O31605" /db_xref="InterPro:IPR001567" /db_xref="InterPro:IPR004438" /db_xref="InterPro:IPR013647" /db_xref="SubtiList:BG13136" /db_xref="UniProtKB/Swiss-Prot:O31605" /translation="MKGTKGKVFRVFTAFLAFVLFITAYDLTKGSEKPEDIHNTSLLR NSCFFNWLESKKTRGITMAEEKKANQLPDRSEVKAEDTWRLEDIFPSDEAWNKEFQAV KELIPNLSKYKGKLADSADHLYEALTYQDKVMERLGRLYTYAHMRSDQDTGNSFYQGL NDKAGNLYTQAASATAYLVPEILSIEEDKLQQFILEKEELKLYSHAIEEITKERPHVL SEKEEALLAEASEVLGSSSNTFSVLNNADITFPSIKDEDGNEKQITHGNFINFLESEN REVRKNAFDAVYKTYGQYKNTMATTLSGTVKKDNFYARVKKYKSAREAALSNNSIPEE VYDNLVKTINKHLPLLHRYIALRKKVLELDEVHIYDLYTPLVKDAGMKVTYEEAKDYM LKGLAPLGEEYASILKEGLENRWVDVYENKGKRNGAYSSGAYGTNPYILMNWHNNVNN LFTLVHEFGHSVHSYYTRKHQPYPYGNYSIFVAEVASTTNEALLGEYLLNNLEDEKQR LYILNHMLEGFRGTVFRQTMFAEFEHLIHTKAQEGEPLTPELLTNVYYDLNKKYFGDG MVIDKEIGLEWSRIPHFYYNYYVYQYATGYSAAQALSSQILKEGKPAVDRYIDFLKAG SSQYPIDVLKKAGVDMTSPEPIEAACKMFEEKLDEMEELLMKVKQS*" /label="pepF CDS" gene 1155302..1157314 /gene="pepF" /locus_tag="BSU_11540" /old_locus_tag="BSU11540" /label="pepF gene" promotor_-35 1155377..1155384 /Source="Nicolas_upshift_promotors" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="promotor_-35" promotor_-10 1155399..1155418 /Source="Nicolas_upshift_promotors" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="promotor_-10" upshifts 1155411 /Source="Nicolas_upshifts" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="upshifts" downshifts 1157261 /Source="Nicolas_upshifts" /id="D627" /incds=0 /nref=98 /ntot=339 /MaxReadThrough="4.70576" /MaxDrop="5.74441" /score="19.0969124" /energy="-15.2" /TU="U933" /idTUdmin="U931" /TUdmin=2 /isTUend="TRUE" /label="downshifts" S_feature 1157315..1157616 /Source="Nicolas_S_feature" /locus_tag="new_1233096_1233397" /HighExp="Etha, dia15, Diami, B60, M9-stat, S8, M0t90, dia5, B36, T0.30H" /AntisenseName="yizD" /AntisenseCor="-1.29003203536192E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.926" /TUlongSig="SigH, SigB" /TUlongPSig="0.999, 0.999" /label="S414" CDS complement(1157352..1157519) /gene="yizD" /locus_tag="BSU_11549" /old_locus_tag="BSU11549" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097703.1" /db_xref="EnsemblGenomes-Gn:BSU11549" /db_xref="EnsemblGenomes-Tr:CAX52593" /db_xref="GOA:C0H3Y6" /db_xref="UniProtKB/Swiss-Prot:C0H3Y6" /translation="MMSTLISIVCIAVFFCLNILGMMHMLPLYITSPLLFLSILFTLY RLNHRKTFKGF*" /label="yizD CDS" gene complement(1157352..1157519) /gene="yizD" /locus_tag="BSU_11549" /old_locus_tag="BSU11549" /label="yizD gene" downshifts complement(1157365) /Source="Nicolas_upshifts" /id="D628" /incds=0 /nref=8 /ntot=61 /MaxReadThrough="1.527" /MaxDrop="5.54041" /score="-4.56163992" /energy="-15.2" /TU="NA" /idTUdmin="U934" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1157539..1157557) /Source="Nicolas_upshift_promotors" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1157555) /Source="Nicolas_upshifts" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1157573..1157578) /Source="Nicolas_upshift_promotors" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1157609..1157616 /Source="Nicolas_upshift_promotors" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1157618..1157743 /Source="Nicolas_S_feature" /locus_tag="new_1233399_1233524" /HighExp="B36, T-1.10H, nit, T-0.40H, M9-tran, LoTm, Pyr, Etha, Salt, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.883" /TUlongSig="SigA, SigH, SigB" /TUlongPSig="0.926, 0.999, 0.999" /label="S415" upshifts 1157618 /Source="Nicolas_upshifts" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1157624..1157762 /gene="roxS" /locus_tag="BSU_misc_RNA_67" /product="small regulatory RNA (NO regulated)" /experiment="publication(s) with functional evidences, PMID:19682248, 19786493, 20511587, 20525796, 25643072, 28436820" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19682248, 19786493, 20511587, 20525796, 25643072, 28436820; Product type n : RNA" /label="roxS RNA" gene 1157624..1157762 /gene="roxS" /locus_tag="BSU_misc_RNA_67" /label="roxS gene" promotor_-10 1157631..1157650 /Source="Nicolas_upshift_promotors" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1157700 /Source="Nicolas_upshifts" /id="D629" /incds=0 /nref=96 /ntot=135 /MaxReadThrough="3.50613" /MaxDrop="9.07209" /score="5.30186633" /energy="-11.6" /TU="U935" /idTUdmin="U933" /TUdmin=89 /isTUend="FALSE" /label="downshifts" CDS complement(1157833..1158732) /gene="spxH" /locus_tag="BSU_11550" /old_locus_tag="BSU11550" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17293416, 17908206, 21378193, 22194450, 24942655, 25353645, 27191337, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17293416, 17908206, 21378193, 22194450, 24942655, 25353645, 27191337, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="thiol management effector of SpxA degradation" /protein_id="NP_389037.2" /db_xref="EnsemblGenomes-Gn:BSU11550" /db_xref="EnsemblGenomes-Tr:CAB13012" /db_xref="GOA:O31606" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13137" /db_xref="UniProtKB/Swiss-Prot:O31606" /translation="MTNYQHELYFAHCHGHPKKPLEIYMFVDPLCPECWSLEPVIKKL KIRYGRFFTLRIIASASLTALNKKRKKHLLAEAWEKIASRSGMSCDGNVWFEQDQPLS SPYMAALAFKAAELQGRKAGMQFLRNMQESLFVSKKNITDENVLLEIAENTSLDLEEF KKDLHSQSAVKALQCDMKIAAEMDVSVNPTLTFFNTQHEDEGLKVPGSYSYDVYEEIL FEMLGDEPKPSETPPLECFIEYFRFVASKEIALVYDLSLEEVEKEMKKLAFAKKVAKV EAKHGMFWKSLSTYSDEYQSCEK*" /label="spxH CDS" gene complement(1157833..1158732) /gene="spxH" /locus_tag="BSU_11550" /old_locus_tag="BSU11550" /label="spxH gene" downshifts complement(1157864) /Source="Nicolas_upshifts" /id="D630" /incds=0 /nref=185 /ntot=251 /MaxReadThrough="3.70729" /MaxDrop="5.65601" /score="17.9327625" /energy="-13.3" /TU="U937" /idTUdmin="U937" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 1158068..1158073 /Source="Nicolas_upshift_promotors" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1158080 /Source="Nicolas_upshifts" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1158089..1158107 /Source="Nicolas_upshift_promotors" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1158096..1159997 /Source="Nicolas_S_feature" /locus_tag="new_1233877_1235778" /HighExp="S6, S4, S5, S8, S3, S7, BT, B36, C30, T5.0H" /AntisenseName="yjbH" /AntisenseCor="-0.61019541931037402" /AntisenseRegPval="-28.1" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S416" CDS complement(1158729..1159127) /gene="yjbI" /locus_tag="BSU_11560" /old_locus_tag="BSU11560" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15866723, 17293416; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol management oxidoreductase component" /protein_id="NP_389038.1" /db_xref="EnsemblGenomes-Gn:BSU11560" /db_xref="EnsemblGenomes-Tr:CAB13013" /db_xref="GOA:O31607" /db_xref="InterPro:IPR001486" /db_xref="InterPro:IPR009050" /db_xref="InterPro:IPR019795" /db_xref="PDB:1UX8" /db_xref="SubtiList:BG13138" /db_xref="UniProtKB/Swiss-Prot:O31607" /translation="MGQSFNAPYEAIGEELLSQLVDTFYERVASHPLLKPIFPSDLTE TARKQKQFLTQYLGGPPLYTEEHGHPMLRARHLPFPITNERADAWLSCMKDAMDHVGL EGEIREFLFGRLELTARHMVNQTEAEDRSS*" /label="yjbI CDS" gene complement(1158729..1159127) /gene="yjbI" /locus_tag="BSU_11560" /old_locus_tag="BSU11560" /label="yjbI gene" S_feature complement(1159128..1159307) /Source="Nicolas_S_feature" /locus_tag="new_1234909_1235088_c" /HighExp="Diami, dia5, dia15, Etha, H2O2, C90, LoTm, Heat, Salt, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.999" /label="S417" promotor_-10 complement(1159299..1159318) /Source="Nicolas_upshift_promotors" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1159307) /Source="Nicolas_upshifts" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1159330..1159337) /Source="Nicolas_upshift_promotors" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1159382..1159927) /gene="cwlQ" /locus_tag="BSU_11570" /old_locus_tag="BSU11570" /EC_number="3.2.1.-" /EC_number="3.2.1.17" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:20609359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20609359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional muramidase and murein lytic transglycosylase" /protein_id="NP_389039.1" /db_xref="EnsemblGenomes-Gn:BSU11570" /db_xref="EnsemblGenomes-Tr:CAB13014" /db_xref="GOA:O31608" /db_xref="InterPro:IPR000189" /db_xref="InterPro:IPR008258" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG13139" /db_xref="UniProtKB/Swiss-Prot:O31608" /translation="MLNSANTTAPSLLSAYGLNSYTSSNSGSVTKAAESTETAVADSA SNKHEANQIRSGDFSIDSAIKKAADKYGVDEKLIRAVIKQESGFNAKAVSGAGAMGLM QLMPSTASSLGVSNPLDPQQNVEGGTKYLKQMLDKYDGNVSMALAAYNAGPGNVDRYG GIPPFQETQNYVKKITSVYYA*" /label="cwlQ CDS" gene complement(1159382..1159927) /gene="cwlQ" /locus_tag="BSU_11570" /old_locus_tag="BSU11570" /label="cwlQ gene" downshifts complement(1159406) /Source="Nicolas_upshifts" /id="D631" /incds=0 /nref=101 /ntot=222 /MaxReadThrough="4.1014" /MaxDrop="5.00847" /score="6.97790581" /energy="-9.1" /TU="U938,U939" /idTUdmin="U938" /TUdmin="-90" /isTUend="FALSE" /label="downshifts" S_feature complement(1159928..1160130) /Source="Nicolas_S_feature" /locus_tag="new_1235709_1235911_c" /HighExp="T0.30H, Gly, C90, GM 10, GM 45, M0t90, Lbstat, C30, Lbtran, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S418" CDS complement(1160131..1160703) /gene="yjbK" /locus_tag="BSU_11580" /old_locus_tag="BSU11580" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9642185, 12456267, 16905149, 20509597, 26904951, 27881678; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative RNA/thiamine triphosphatase" /protein_id="NP_389040.1" /db_xref="EnsemblGenomes-Gn:BSU11580" /db_xref="EnsemblGenomes-Tr:CAB13015" /db_xref="GOA:O31609" /db_xref="InterPro:IPR009195" /db_xref="InterPro:IPR023577" /db_xref="InterPro:IPR033469" /db_xref="SubtiList:BG13140" /db_xref="UniProtKB/Swiss-Prot:O31609" /translation="MSQEIEIEFKNMLTKQEFKNIASALQLTEKDFTDQKNHYFDTDS FALKQKHAALRIRRKNGKYVLTLKEPADVGLLETHQQLSEVSDLAGFSVPEGPVKDQL HKLQIDTDAIQYFGSLATNRAEKETEKGLIVLDHSRYLNKEDYEIEFEAADWHEGRQA FEKLLQQFSIPQRETKNKILRFYEEKRKSI*" /label="yjbK CDS" gene complement(1160131..1160703) /gene="yjbK" /locus_tag="BSU_11580" /old_locus_tag="BSU11580" /label="yjbK gene" promotor_-10 complement(1160276..1160294) /Source="Nicolas_upshift_promotors" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-10" upshifts complement(1160285) /Source="Nicolas_upshifts" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="upshifts" promotor_-35 complement(1160307..1160314) /Source="Nicolas_upshift_promotors" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-35" promotor_-10 complement(1160732..1160751) /Source="Nicolas_upshift_promotors" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-10" upshifts complement(1160749) /Source="Nicolas_upshifts" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="upshifts" promotor_-35 1160765..1160768 /Source="Nicolas_upshift_promotors" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1160766..1160773) /Source="Nicolas_upshift_promotors" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-35" upshifts 1160781 /Source="Nicolas_upshifts" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1160784..1160803 /Source="Nicolas_upshift_promotors" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1160828..1161196 /gene="yjbL" /locus_tag="BSU_11590" /old_locus_tag="BSU11590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389041.1" /db_xref="EnsemblGenomes-Gn:BSU11590" /db_xref="EnsemblGenomes-Tr:CAB13016" /db_xref="InterPro:IPR020908" /db_xref="SubtiList:BG13141" /db_xref="UniProtKB/Swiss-Prot:O31610" /translation="MQNRIEILNATLSDDQLRLACQTEGNEAERKPSGQMLVDSDHFA FVYILELADSFEYVIIKEHVWPELKQAHAQKIPVVLEAGDQTIELAGLHEELEYLLEN IKDNANYGEEMEEKVKRVFL*" /label="yjbL CDS" gene 1160828..1161196 /gene="yjbL" /locus_tag="BSU_11590" /old_locus_tag="BSU11590" /label="yjbL gene" CDS 1161225..1161860 /gene="relP" /locus_tag="BSU_11600" /old_locus_tag="BSU11600" /EC_number="2.7.6.5" /function="16.1: Circulate" /function="16.14: Store" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17714452, 18067544, 19447912, 24163341, 25331430, 26825398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17714452, 18067544, 19447912, 24163341, 25331430, 26825398; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="(p)ppGpp synthetase" /protein_id="NP_389042.1" /db_xref="EnsemblGenomes-Gn:BSU11600" /db_xref="EnsemblGenomes-Tr:CAB13017" /db_xref="GOA:O31611" /db_xref="InterPro:IPR007685" /db_xref="PDB:5DEC" /db_xref="PDB:5DED" /db_xref="PDB:5F2V" /db_xref="SubtiList:BG13142" /db_xref="UniProtKB/Swiss-Prot:O31611" /translation="MDDKQWERFLVPYRQAVEELKVKLKGIRTLYEYEDDHSPIEFVT GRVKPVASILEKARRKSIPLHEIETMQDIAGLRIMCQFVDDIQIVKEMLFARKDFTVV DQRDYIAEHKESGYRSYHLVVLYPLQTVSGEKHVLVEIQIRTLAMNFWATIEHSLNYK YSGNIPEKVKLRLQRASEAASRLDEEMSEIRGEVQEAQAAFSRKKKGSEQQ*" /label="relP CDS" gene 1161225..1161860 /gene="relP" /locus_tag="BSU_11600" /old_locus_tag="BSU11600" /label="relP gene" CDS 1161879..1162679 /gene="ppnKA" /locus_tag="BSU_11610" /old_locus_tag="BSU11610" /EC_number="2.7.1.23" /function="16.14: Store" /function="16.7: Manage energy" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 12897004, 16233726, 16511117, 18720024, 24048943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12897004, 16233726, 16511117, 18720024, 24048943; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="inorganic polyphosphate/ATP-NAD kinase (quinolate activated)" /protein_id="NP_389043.1" /db_xref="EnsemblGenomes-Gn:BSU11610" /db_xref="EnsemblGenomes-Tr:CAB13018" /db_xref="GOA:O31612" /db_xref="InterPro:IPR002504" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017437" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13143" /db_xref="UniProtKB/Swiss-Prot:O31612" /translation="MKFAVSSKGDQVSDTLKSKIQAYLLDFDMELDENEPEIVISVGG DGTLLYAFHRYSDRLDKTAFVGVHTGHLGFYADWVPHEIEKLVLAIAKTPYHTVEYPL LEVIVTYHENEREERYLALNECTIKSIEGSLVADVEIKGQLFETFRGDGLCLSTPSGS TAYNKALGGAIIHPSIRAIQLAEMASINNRVFRTVGSPLLLPSHHDCMIKPRNEVDFQ VTIDHLTLLHKDVKSIRCQVASEKVRFARFRPFPFWKRVQDSFIGKGE*" /label="ppnKA CDS" gene 1161879..1162679 /gene="ppnKA" /locus_tag="BSU_11610" /old_locus_tag="BSU11610" /label="ppnKA gene" CDS 1162742..1163593 /gene="yjbO" /locus_tag="BSU_11620" /old_locus_tag="BSU11620" /EC_number="5.4.99.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pseudouridylate synthase" /protein_id="NP_389044.1" /db_xref="EnsemblGenomes-Gn:BSU11620" /db_xref="EnsemblGenomes-Tr:CAB13019" /db_xref="GOA:O31613" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="SubtiList:BG13144" /db_xref="UniProtKB/Swiss-Prot:O31613" /translation="MTVKEYAGELGISKRLLTDIKFGGGDLQINGEHVTVKYVLKEGD LLIVKFPEEQVSETLLAEPVPLDILYEDEHVLVINKQPYVSSIPSREHPSGSIANGII DHYQTTGVRATVHLVTRLDRDTSGIMLVAKHRFAHSILSSAQKNGLVKRRYAAVVHGR MAQMEGTVDAPIGRHPDSIIERTVTPDGQKAVTHFYVTCANDDMTSVALQLETGRTHQ IRVHMSYLGHPLCGDTLYGGTRQEIGRQALHSEHLSFIHPLTQENMRFHAPLPQDMSK LIKGENH*" /label="yjbO CDS" gene 1162742..1163593 /gene="yjbO" /locus_tag="BSU_11620" /old_locus_tag="BSU11620" /label="yjbO gene" downshifts 1163552 /Source="Nicolas_upshifts" /id="D632" /incds=0 /nref=203 /ntot=256 /MaxReadThrough="0.25796" /MaxDrop="5.73002" /score="21.4914497" /energy="-12.8" /TU="NA" /idTUdmin="U940" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1163606..1164340) /gene="prpE" /locus_tag="BSU_11630" /old_locus_tag="BSU11630" /EC_number="3.6.1.17" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12059787, 16740944, 21092197, 23824080, 28516732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12059787, 16740944, 21092197, 23824080, 28516732; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphorylated protein phosphatase E and diadenosine-polyphosphate hydrolase" /protein_id="NP_389045.1" /db_xref="EnsemblGenomes-Gn:BSU11630" /db_xref="EnsemblGenomes-Tr:CAB13020" /db_xref="GOA:O31614" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR023937" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13145" /db_xref="UniProtKB/Swiss-Prot:O31614" /translation="MAYDIISDIHGCYDEMTALIQKLGYTIKNGVPVHEEGRVLVFAG DLTDRGPKSIEVIRFVAGAYEKGAVRYVPGNHCNKLYRYLKGNPVKVMHGLETTAAEL EELSKDEKKSVSEQFMKLYETAPLYDILHNGELVVAHAGIRADDIGKYTRRVKDFVLY GDVTGETYPDGRPIRRDWAAAYNGKAWVVYGHTPVKEPRKVNRTINIDTGCVFGNQLT GFRFPEIETVSVPSSLPYDESRFRPI*" /label="prpE CDS" gene complement(1163606..1164340) /gene="prpE" /locus_tag="BSU_11630" /old_locus_tag="BSU11630" /label="prpE gene" downshifts complement(1163628) /Source="Nicolas_upshifts" /id="D633" /incds=0 /nref=22 /ntot=152 /MaxReadThrough="1.18091" /MaxDrop="3.57735" /score="3.24324561" /energy="-12.8" /TU="NA" /idTUdmin="U938" /TUdmin="-4312" /isTUend="FALSE" /label="downshifts" promotor_-35 1164462..1164466 /Source="Nicolas_upshift_promotors" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="promotor_-35" promotor_-10 1164483..1164502 /Source="Nicolas_upshift_promotors" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="promotor_-10" upshifts 1164497 /Source="Nicolas_upshifts" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="upshifts" S_feature 1164498..1164574 /Source="Nicolas_S_feature" /locus_tag="new_1240279_1240355" /HighExp="H2O2, Diami, dia15, Paraq, Oxctl, Heat, G180, Salt, BMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S419" CDS 1164575..1166419 /gene="kefQ" /locus_tag="BSU_11640" /old_locus_tag="BSU11640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 21742892, 24330391; Product type t: transporter" /codon_start=1 /transl_table=11 /product="gated K+/H+ antiporter" /protein_id="NP_389046.1" /db_xref="EnsemblGenomes-Gn:BSU11640" /db_xref="EnsemblGenomes-Tr:CAB13021" /db_xref="GOA:O31615" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR006153" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG13146" /db_xref="UniProtKB/Swiss-Prot:O31615" /translation="MAHTSVASLVVVLIVAFLTPILLHRFKLSIPVVVAEIIMGLIIG KSGLNLVVEGDTWLQTLSMLGFIFLMFLSGLEIDFSSFEKGKKKQFLPNGKEAPNTFA AASVIFVGIFILSLLLSYGFVLAGFIQNAFLMTLIISTISLGVVVPTLKEERIMNSNI GQIILLVAVIADLATMILLAVFSSLYGEDSGNMWLLMILFAAGVVLYFFGRVFKHRSF VQSMSKGTIQIGTRAIFTLIIVLVALSESLGAENILGAFLAGVLVSLLSPNKELVQQL DSFGYGFLIPIFFVMVGVKLDIWTLFQDKTILIMIPLLLLALLVSKIIPVMYLKKWYD NRTIFASGFLLTSTLSLVIAAATIGQQLHVISTNMSGALILVAVIASIFTPICFKKLY KREEQPEEKKTITFIGANQMTLPVTLELPEEEYDVRVVHVYQENAEEKLSESVFAVET ISDYEHETLESLGIFETDILVVATGNEDMNADIALLAKDKGTERVIASVGSPEHEAAL KEQGISIFSILLSTKTLLRALIEAPGVMKLLTNQESSLYQINMENSKYDGVILREFPL TGDVIFVRIFRGVDSIVPHGDTRLKLGDRLIVTGSRGYVTDLKKTLEG*" /label="kefQ CDS" gene 1164575..1166419 /gene="kefQ" /locus_tag="BSU_11640" /old_locus_tag="BSU11640" /label="kefQ gene" misc_feature complement(1164902..1164921) /Source="Nicolas_upshift_promotors" /id="U942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.996003996003996" /xcortree=3108 /SigmaFactorBS="taatcagggtcatcaaaaatgcattttggataaatccggcca agacgaacccataggacaagagcAATGATAAAATAAAAATACCgacgaaaataacaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1164926) /Source="Nicolas_upshifts" /id="U942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.996003996003996" /xcortree=3108 /SigmaFactorBS="taatcagggtcatcaaaaatgcattttggataaatccggcca agacgaacccataggacaagagcAATGATAAAATAAAAATACCgacgaaaataacaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1166421..1166428 /Source="Nicolas_upshift_promotors" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="promotor_-35" promotor_-10 1166442..1166461 /Source="Nicolas_upshift_promotors" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="promotor_-10" upshifts 1166448 /Source="Nicolas_upshifts" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="upshifts" misc_RNA 1166481..1166589 /gene="tswA" /locus_tag="BSU_misc_RNA_14" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswA RNA" gene 1166481..1166589 /gene="tswA" /locus_tag="BSU_misc_RNA_14" /label="tswA gene" downshifts 1166584 /Source="Nicolas_upshifts" /id="D634" /incds=0 /nref=20 /ntot=84 /MaxReadThrough="7.67021" /MaxDrop="5.27759" /score="34.8346124" /energy="-12.5" /TU="U943" /idTUdmin="U941" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS 1166668..1167378 /gene="tenA" /locus_tag="BSU_11650" /old_locus_tag="BSU11650" /EC_number="3.5.99.2" /function="4.11: Thiamine" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15709744, 15858269, 16356850, 17618314, 18054064, 24311574" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15709744, 15858269, 16356850, 17618314, 18054064, 24311574; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiaminase II" /protein_id="NP_389047.1" /db_xref="EnsemblGenomes-Gn:BSU11650" /db_xref="EnsemblGenomes-Tr:CAB13022" /db_xref="GOA:P25052" /db_xref="InterPro:IPR004305" /db_xref="InterPro:IPR016084" /db_xref="InterPro:IPR027574" /db_xref="PDB:1TO9" /db_xref="PDB:1TYH" /db_xref="PDB:1YAF" /db_xref="PDB:1YAK" /db_xref="PDB:2QCX" /db_xref="SubtiList:BG10791" /db_xref="UniProtKB/Swiss-Prot:P25052" /translation="MKFSEECRSAAAEWWEGSFVHPFVQGIGDGTLPIDRFKYYVLQD SYYLTHFAKVQSFGAAYAKDLYTTGRMASHAQGTYEAEMALHREFAELLEISEEERKA FKPSPTAYSYTSHMYRSVLSGNFAEILAALLPCYWLYYEVGEKLLHCDPGHPIYQKWI GTYGGDWFRQQVEEQINRFDELAENSTEEVRAKMKENFVISSYYEYQFWGMAYRKEGW SDSAIKEVEECGASRHNG*" /label="tenA CDS" gene 1166668..1167378 /gene="tenA" /locus_tag="BSU_11650" /old_locus_tag="BSU11650" /label="tenA gene" CDS 1167353..1167970 /gene="tenI" /locus_tag="BSU_11660" /old_locus_tag="BSU11660" /EC_number="5.3.99.10" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15709744, 15858269, 16356850, 21534620" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15709744, 15858269, 16356850, 21534620; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiazole tautomerase" /protein_id="NP_389048.1" /db_xref="EnsemblGenomes-Gn:BSU11660" /db_xref="EnsemblGenomes-Tr:CAB13023" /db_xref="GOA:P25053" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022998" /db_xref="InterPro:IPR036206" /db_xref="PDB:1YAD" /db_xref="PDB:3QH2" /db_xref="SubtiList:BG10792" /db_xref="UniProtKB/Swiss-Prot:P25053" /translation="MELHAITDDSKPVEELARIIITIQNEVDFIHIRERSKSAADILK LLDLIFEGGIDKRKLVMNGRVDIALFSTIHRVQLPSGSFSPKQIRARFPHLHIGRSVH SLEEAVQAEKEDADYVLFGHVFETDCKKGLEGRGVSLLSDIKQRISIPVIAIGGMTPD RLRDVKQAGADGIAVMSGIFSSAEPLEAARRYSRKLKEMRYEKAL*" /label="tenI CDS" gene 1167353..1167970 /gene="tenI" /locus_tag="BSU_11660" /old_locus_tag="BSU11660" /label="tenI gene" CDS 1167954..1169063 /gene="thiO" /locus_tag="BSU_11670" /old_locus_tag="BSU11670" /EC_number="1.4.3.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9827558, 11744710, 12627963, 15105420, 19751796, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9827558, 11744710, 12627963, 15105420, 19751796, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="FAD-dependent glycine oxidase" /protein_id="NP_389049.1" /db_xref="EnsemblGenomes-Gn:BSU11670" /db_xref="EnsemblGenomes-Tr:CAB13024" /db_xref="GOA:O31616" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR012727" /db_xref="InterPro:IPR036188" /db_xref="PDB:1NG3" /db_xref="PDB:1NG4" /db_xref="PDB:1RYI" /db_xref="PDB:3IF9" /db_xref="SubtiList:BG13147" /db_xref="UniProtKB/Swiss-Prot:O31616" /translation="MKRHYEAVVIGGGIIGSAIAYYLAKENKNTALFESGTMGGRTTS AAAGMLGAHAECEERDAFFDFAMHSQRLYKGLGEELYALSGVDIRQHNGGMFKLAFSE EDVLQLRQMDDLDSVSWYSKEEVLEKEPYASGDIFGASFIQDDVHVEPYFVCKAYVKA AKMLGAEIFEHTPVLHVERDGEALFIKTPSGDVWANHVVVASGVWSGMFFKQLGLNNA FLPVKGECLSVWNDDIPLTKTLYHDHCYIVPRKSGRLVVGATMKPGDWSETPDLGGLE SVMKKAKTMLPAIQNMKVDRFWAGLRPGTKDGKPYIGRHPEDSRILFAAGHFRNGILL APATGALISDLIMNKEVNQDWLHAFRIDRKEAVQI*" /label="thiO CDS" gene 1167954..1169063 /gene="thiO" /locus_tag="BSU_11670" /old_locus_tag="BSU11670" /label="thiO gene" CDS 1169063..1169263 /gene="thiS" /locus_tag="BSU_11680" /old_locus_tag="BSU11680" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10939241, 14567704, 14757766, 15489164, 22616866, 26443755; Product type c : carrier" /codon_start=1 /transl_table=11 /product="sulfur carrier for synthesis of hydroxyethylthiazole phosphate" /protein_id="NP_389050.1" /db_xref="EnsemblGenomes-Gn:BSU11680" /db_xref="EnsemblGenomes-Tr:CAB13025" /db_xref="GOA:O31617" /db_xref="InterPro:IPR003749" /db_xref="InterPro:IPR010035" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR016155" /db_xref="PDB:1TYG" /db_xref="SubtiList:BG13148" /db_xref="UniProtKB/Swiss-Prot:O31617" /translation="MLQLNGKDVKWKKDTGTIQDLLASYQLENKIVIVERNKEIIGKE RYHEVELCDRDVIEIVHFVGGG*" /label="thiS CDS" gene 1169063..1169263 /gene="thiS" /locus_tag="BSU_11680" /old_locus_tag="BSU11680" /label="thiS gene" CDS 1169260..1170030 /gene="thiG" /locus_tag="BSU_11690" /old_locus_tag="BSU11690" /EC_number="2.8.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 12627963, 14567704, 14757766, 15489164, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 12627963, 14567704, 14757766, 15489164, 22938038; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="hydroxyethylthiazole phosphate synthetase (thiamine biosynthesis)" /protein_id="NP_389051.1" /db_xref="EnsemblGenomes-Gn:BSU11690" /db_xref="EnsemblGenomes-Tr:CAB13026" /db_xref="GOA:O31618" /db_xref="InterPro:IPR008867" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR033983" /db_xref="PDB:1TYG" /db_xref="PDB:1XM3" /db_xref="SubtiList:BG13149" /db_xref="UniProtKB/Swiss-Prot:O31618" /translation="MSMLTIGGKSFQSRLLLGTGKYPSFDIQKEAVAVSESDILTFAV RRMNIFEASQPNFLEQLDLSKYTLLPNTAGASTAEEAVRIARLAKASGLCDMIKVEVI GCSRSLLPDPVETLKASEQLLEEGFIVLPYTSDDVVLARKLEELGVHAIMPGASPIGS GQGILNPLNLSFIIEQAKVPVIVDAGIGSPKDAAYAMELGADGVLLNTAVSGADDPVK MARAMKLAVEAGRLSYEAGRIPLKQYGTASSPGEGLPV*" /label="thiG CDS" gene 1169260..1170030 /gene="thiG" /locus_tag="BSU_11690" /old_locus_tag="BSU11690" /label="thiG gene" CDS 1170027..1171037 /gene="thiF" /locus_tag="BSU_11700" /old_locus_tag="BSU11700" /EC_number="2.7.7.73" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14567704, 14757766, 15489164, 16388576, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14567704, 14757766, 15489164, 16388576, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="adenylate transferase and sulfur transferase (thiamine biosynthesis)" /protein_id="NP_389052.1" /db_xref="EnsemblGenomes-Gn:BSU11700" /db_xref="EnsemblGenomes-Tr:CAB13027" /db_xref="GOA:O31619" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG13150" /db_xref="UniProtKB/Swiss-Prot:O31619" /translation="MTGRYSRQELFAPIGPSGQKKLKEARAVIIGAGALGTASAEMLV RAGVGSVKIADRDYVEWSNLQRQQLYTEDDVKKEMPKAAAAERRLRSINSDVDVTGLV MDVTAENIFELIRDASIIVDAADNFETRLIVNDAAVKEGIPFLYGACVGSYGLTFTVV PGSTPCLHCLLDALPIGGATCDTAGIISPAVLQVAVFQVTDALKLLTGEECEPVLRSF DLWKNERSEVRAASLKHDACPSCGTKDFPFLSYENQTKAAVLCGRNTVQIRSSITKEA DLEALAGQLRQAGLEVAANPYLISCRSDDMKMVLFRDGRALIHGTNDIARAKSIYHKW IG*" /label="thiF CDS" gene 1170027..1171037 /gene="thiF" /locus_tag="BSU_11700" /old_locus_tag="BSU11700" /label="thiF gene" CDS 1171056..1171871 /gene="thiD" /locus_tag="BSU_11710" /old_locus_tag="BSU11710" /EC_number="2.7.4.7" /EC_number="2.7.1.49" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 12627963, 14973012, 16952958, 17012797, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 12627963, 14973012, 16952958, 17012797, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphomethylpyrimidine kinase, 4-amino-5-hydroxymethyl-2-methylpyrimidine and 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate kinase" /protein_id="NP_389053.1" /db_xref="EnsemblGenomes-Gn:BSU11710" /db_xref="EnsemblGenomes-Tr:CAB13028" /db_xref="GOA:O31620" /db_xref="InterPro:IPR004399" /db_xref="InterPro:IPR013749" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG13151" /db_xref="UniProtKB/Swiss-Prot:O31620" /translation="MSIYKALTIAGSDSGGGAGIQADIKTFQELDVFGMSAITAVTAQ NTLGVHGVHPLTVETLRQQIDAVAEDLRPDAVKTGMLWNADMIEEVARKIDEYGFNRV IVDPVMIAKGGASLLRDESVATLKELLIPRSYAITPNVPEAETLTGMTISSLDDRKKA AEQLVKMGAQHVIIKGGHQPEDNHITDLLFDGSMFMQITHPYINTKHTHGTGCTFAAA LTAQTAKGDSIHQAFEVAANFVREAVENTLGIGSGHGPTNHFAFKRNSLNTSR*" /label="thiD CDS" gene 1171056..1171871 /gene="thiD" /locus_tag="BSU_11710" /old_locus_tag="BSU11710" /label="thiD gene" downshifts 1171845 /Source="Nicolas_upshifts" /id="D635" /incds=0 /nref=128 /ntot=172 /MaxReadThrough="3.33485" /MaxDrop="5.0154" /score="3.40314581" /energy="-14.8" /TU="U943" /idTUdmin="U943" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 1171918..1171924 /Source="Nicolas_upshift_promotors" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1171937..1171956 /Source="Nicolas_upshift_promotors" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1171947 /Source="Nicolas_upshifts" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="upshifts" CDS 1172007..1172783 /gene="fabI" /locus_tag="BSU_11720" /old_locus_tag="BSU11720" /EC_number="1.3.1.9" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11007778, 15105103, 21185310, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007778, 15105103, 21185310, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-acyl carrier protein reductase" /protein_id="NP_389054.2" /db_xref="EnsemblGenomes-Gn:BSU11720" /db_xref="EnsemblGenomes-Tr:CAB13029" /db_xref="GOA:P54616" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR014358" /db_xref="InterPro:IPR036291" /db_xref="PDB:3OIF" /db_xref="PDB:3OIG" /db_xref="SubtiList:BG13152" /db_xref="UniProtKB/Swiss-Prot:P54616" /translation="MNFSLEGRNIVVMGVANKRSIAWGIARSLHEAGARLIFTYAGER LEKSVHELAGTLDRNDSIILPCDVTNDAEIETCFASIKEQVGVIHGIAHCIAFANKEE LVGEYLNTNRDGFLLAHNISSYSLTAVVKAARPMMTEGGSIVTLTYLGGELVMPNYNV MGVAKASLDASVKYLAADLGKENIRVNSISAGPIRTLSAKGISDFNSILKDIEERAPL RRTTTPEEVGDTAAFLFSDMSRGITGENLHVDSGFHITAR*" /label="fabI CDS" gene 1172007..1172783 /gene="fabI" /locus_tag="BSU_11720" /old_locus_tag="BSU11720" /label="fabI gene" downshifts 1172772 /Source="Nicolas_upshifts" /id="D636" /incds=0 /nref=229 /ntot=313 /MaxReadThrough="3.12901" /MaxDrop="6.64182" /score="33.5478109" /energy="-11.8" /TU="U944" /idTUdmin="U944" /TUdmin="-416" /isTUend="FALSE" /label="downshifts" promotor_-35 1172831..1172836 /Source="Nicolas_upshift_promotors" /id="U945" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=1095 /SigmaFactorBS="tcaagcaatcccgaatagggattgcttttttatttCTTCTGa ttttcagctttctgTCATATAGATAGAATATGAcacaatcggagggatgaagatgtct a" /listShort="cotO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1172852..1172870 /Source="Nicolas_upshift_promotors" /id="U945" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=1095 /SigmaFactorBS="tcaagcaatcccgaatagggattgcttttttatttCTTCTGa ttttcagctttctgTCATATAGATAGAATATGAcacaatcggagggatgaagatgtct a" /listShort="cotO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1172856 /Source="Nicolas_upshifts" /id="U945" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=1095 /SigmaFactorBS="tcaagcaatcccgaatagggattgcttttttatttCTTCTGa ttttcagctttctgTCATATAGATAGAATATGAcacaatcggagggatgaagatgtct a" /listShort="cotO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1172868..1172882) /Source="Nicolas_upshift_promotors" /id="U946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.001998001998002" /xcortree=1241 /SigmaFactorBS="gagcggttttttatccgcgtttcttttcttattaGACATctt catcCCTCCGATTGTGTCAtattctatctatatgacagaaagctgaaaatcagaagaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1172868) /Source="Nicolas_upshifts" /id="U946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.001998001998002" /xcortree=1241 /SigmaFactorBS="gagcggttttttatccgcgtttcttttcttattaGACATctt catcCCTCCGATTGTGTCAtattctatctatatgacagaaagctgaaaatcagaagaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1172884..1173567 /gene="cotO" /locus_tag="BSU_11730" /old_locus_tag="BSU11730" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16321932" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16321932; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore outer coat protein" /protein_id="NP_389055.1" /db_xref="EnsemblGenomes-Gn:BSU11730" /db_xref="EnsemblGenomes-Tr:CAB13030" /db_xref="GOA:O31622" /db_xref="InterPro:IPR025439" /db_xref="SubtiList:BG13153" /db_xref="UniProtKB/Swiss-Prot:O31622" /translation="MKMSNKKRNADKKPLMYIVQPDYAETTRSSMQEIVIKRKADKPA PPKAEEKPAYHEKQQEEAVAQDVLQEDQKPAAEPVSQQTQEAREPENIKSQEEQKAEP QAVEETVEHEPPKAEKKEEPALEARKPEKEPEAVHSADKAEEKAPPARKVKKPMSKMT IHEKIDFLTKLPHNMPRALCLIEANGRTYRGVIVGRRNDSVLLRTTGNGAPTELAIDD ITSLHPLGF*" /label="cotO CDS" gene 1172884..1173567 /gene="cotO" /locus_tag="BSU_11730" /old_locus_tag="BSU11730" /label="cotO gene" promotor_-35 complement(1172890..1172894) /Source="Nicolas_upshift_promotors" /id="U946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.001998001998002" /xcortree=1241 /SigmaFactorBS="gagcggttttttatccgcgtttcttttcttattaGACATctt catcCCTCCGATTGTGTCAtattctatctatatgacagaaagctgaaaatcagaagaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1173562 /Source="Nicolas_upshifts" /id="D637" /incds=0 /nref=4 /ntot=40 /MaxReadThrough="3.37645" /MaxDrop="4.6587" /score="18.0229289" /energy="-13.4" /TU="U945" /idTUdmin="U945" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 1173650 /Source="Nicolas_upshifts" /id="D638" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="2.44926" /MaxDrop="4.55934" /score="18.0229289" /energy="-13.4" /TU="NA" /idTUdmin="U945" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(1173661..1174107) /gene="cotZ" /locus_tag="BSU_11740" /old_locus_tag="BSU11740" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7519271, 8509331, 19933362, 26341943, 27320701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7519271, 8509331, 19933362, 26341943, 27320701; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein (insoluble fraction, crust layer)" /protein_id="NP_389056.1" /db_xref="EnsemblGenomes-Gn:BSU11740" /db_xref="EnsemblGenomes-Tr:CAB13031" /db_xref="GOA:Q08312" /db_xref="InterPro:IPR019593" /db_xref="SubtiList:BG10499" /db_xref="UniProtKB/Swiss-Prot:Q08312" /translation="MSQKTSSCVREAVENIEDLQNAVEEDCPTGCHSKLLSVSHSLGD TVPFAIFTSKSTPLVAFGNVGELDNGPCFNTVFFRVERVHGSCATLSLLIAFDEHKHI LDFTDKDTVCEVFRLEKTNYCIEVDLDCFCAINCLNPRLINRTHHH*" /label="cotZ CDS" gene complement(1173661..1174107) /gene="cotZ" /locus_tag="BSU_11740" /old_locus_tag="BSU11740" /label="cotZ gene" downshifts complement(1173682) /Source="Nicolas_upshifts" /id="D639" /incds=0 /nref=7 /ntot=50 /MaxReadThrough="8.44444" /MaxDrop="7.17581" /score="2.03943557" /energy="-9.3" /TU="U949" /idTUdmin="U950" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1174108..1174234) /Source="Nicolas_S_feature" /locus_tag="new_1249889_1250015_c" /HighExp="S8, S7, S6, BT, S5, B36, G/S, Pyr, B60, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigEF" /TUshortPSig="1, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S420" CDS complement(1174235..1174723) /gene="cotY" /locus_tag="BSU_11750" /old_locus_tag="BSU11750" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7519271, 8509331, 14766913, 26341943, 26821119" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7519271, 8509331, 14766913, 26341943, 26821119; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="outer spore coat protein (crust layer, insolublefraction)" /protein_id="NP_389057.1" /db_xref="EnsemblGenomes-Gn:BSU11750" /db_xref="EnsemblGenomes-Tr:CAB13032" /db_xref="GOA:Q08311" /db_xref="InterPro:IPR019593" /db_xref="SubtiList:BG10498" /db_xref="UniProtKB/Swiss-Prot:Q08311" /translation="MSCGKTHGRHENCVCDAVEKILAEQEAVEEQCPTGCYTNLLNPT IAGKDTIPFLVFDKKGGLFSTFGNVGGFVDDMQCFESIFFRVEKLCDCCATLSILRPV DVKGDTLSVCHPCDPDFFGLEKTDFCIEVDLGCFCAIQCLSPELVDRTSPHKDKKHHH NG*" /label="cotY CDS" gene complement(1174235..1174723) /gene="cotY" /locus_tag="BSU_11750" /old_locus_tag="BSU11750" /label="cotY gene" promotor_-35 1174403..1174409 /Source="Nicolas_upshift_promotors" /id="U947" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.53046953046953" /psig="0.653346653346653" /xcortree=1630 /SigmaFactorBS="agggtggcaaacacttaaggtATCGCCTttgacatcgaccgg GCGTAAAATAGACAGTGTTGcacagcaatcgcataatttttcgacgcggaagaaaatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1174424..1174443 /Source="Nicolas_upshift_promotors" /id="U947" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.53046953046953" /psig="0.653346653346653" /xcortree=1630 /SigmaFactorBS="agggtggcaaacacttaaggtATCGCCTttgacatcgaccgg GCGTAAAATAGACAGTGTTGcacagcaatcgcataatttttcgacgcggaagaaaatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1174442 /Source="Nicolas_upshifts" /id="U947" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.53046953046953" /psig="0.653346653346653" /xcortree=1630 /SigmaFactorBS="agggtggcaaacacttaaggtATCGCCTttgacatcgaccgg GCGTAAAATAGACAGTGTTGcacagcaatcgcataatttttcgacgcggaagaaaatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1174719..1174723 /Source="Nicolas_upshift_promotors" /id="U948" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.002997002997003" /xcortree=1244 /SigmaFactorBS="tctcatgccggccatgggtttttccgcagCTCATtgatttca GCTCCTTCTTTATAGggtatttgactttagtccttaacaacatatgtacccgtgcccc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1174732..1174746 /Source="Nicolas_upshift_promotors" /id="U948" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.002997002997003" /xcortree=1244 /SigmaFactorBS="tctcatgccggccatgggtttttccgcagCTCATtgatttca GCTCCTTCTTTATAGggtatttgactttagtccttaacaacatatgtacccgtgcccc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1174750 /Source="Nicolas_upshifts" /id="U948" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.002997002997003" /xcortree=1244 /SigmaFactorBS="tctcatgccggccatgggtttttccgcagCTCATtgatttca GCTCCTTCTTTATAGggtatttgactttagtccttaacaacatatgtacccgtgcccc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1174760..1174779) /Source="Nicolas_upshift_promotors" /id="U949" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1280 /SigmaFactorBS="tattttccaagcatatgatgaatatatagacgttcACCCACA CCAagtggggcacgggTACATATGTTGTTAAGGACTaaagtcaaataccctataaaga a" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1174777) /Source="Nicolas_upshifts" /id="U949" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1280 /SigmaFactorBS="tattttccaagcatatgatgaatatatagacgttcACCCACA CCAagtggggcacgggTACATATGTTGTTAAGGACTaaagtcaaataccctataaaga a" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1174793..1174802) /Source="Nicolas_upshift_promotors" /id="U949" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1280 /SigmaFactorBS="tattttccaagcatatgatgaatatatagacgttcACCCACA CCAagtggggcacgggTACATATGTTGTTAAGGACTaaagtcaaataccctataaaga a" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1174809..1174827) /Source="Nicolas_upshift_promotors" /id="U950" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1006 /SigmaFactorBS="cttgtcctctaggacctaaaagcagagctaaaaacgctCTGC TTtttcttattttccaaGCATATGATGAATATATAGacgttcacccacaccaagtggg g" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1174826) /Source="Nicolas_upshifts" /id="U950" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1006 /SigmaFactorBS="cttgtcctctaggacctaaaagcagagctaaaaacgctCTGC TTtttcttattttccaaGCATATGATGAATATATAGacgttcacccacaccaagtggg g" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1174843..1174848) /Source="Nicolas_upshift_promotors" /id="U950" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1006 /SigmaFactorBS="cttgtcctctaggacctaaaagcagagctaaaaacgctCTGC TTtttcttattttccaaGCATATGATGAATATATAGacgttcacccacaccaagtggg g" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1174860 /Source="Nicolas_upshifts" /id="D640" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="1.28604" /MaxDrop="4.18677" /score="-9.76125107" /energy="-10.4" /TU="NA" /idTUdmin="U948" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(1174875..1175393) /gene="cotX" /locus_tag="BSU_11760" /old_locus_tag="BSU11760" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7519271, 8509331, 10400595, 10788508, 12031481, 19304857, 26821119" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7519271, 8509331, 10400595, 10788508, 12031481, 19304857, 26821119; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (insoluble fraction)" /protein_id="NP_389058.1" /db_xref="EnsemblGenomes-Gn:BSU11760" /db_xref="EnsemblGenomes-Tr:CAB13033" /db_xref="GOA:Q08313" /db_xref="InterPro:IPR011428" /db_xref="SubtiList:BG10500" /db_xref="UniProtKB/Swiss-Prot:Q08313" /translation="MESRPYSWVALDPDCDHPLDDKEKDKEKHERKCHCDVCCNGNGF FGNDNAFIDQDLAQANLNKQVSDETIIIRDSCDINVTSTDVQAVTSVVTALNAAVVTA TLTSIADGVIAELVAQDLLQLTANKQVNRQKLLIECSRGVNVTTVDADIATLISTATN TLVAILVITLVL*" /label="cotX CDS" gene complement(1174875..1175393) /gene="cotX" /locus_tag="BSU_11760" /old_locus_tag="BSU11760" /label="cotX gene" downshifts complement(1174899) /Source="Nicolas_upshifts" /id="D641" /incds=0 /nref=76 /ntot=102 /MaxReadThrough="1.79219" /MaxDrop="8.69761" /score="18.5755652" /energy="-10.4" /TU="U952" /idTUdmin="U952" /TUdmin="-29" /isTUend="FALSE" /label="downshifts" downshifts 1174904 /Source="Nicolas_upshifts" /id="D642" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="1.2156" /MaxDrop="3.69222" /score="-9.76125107" /energy="-10.4" /TU="NA" /idTUdmin="U948" /TUdmin=66 /isTUend="FALSE" /label="downshifts" S_feature complement(1175394..1175491) /Source="Nicolas_S_feature" /locus_tag="new_1251175_1251272_c" /HighExp="S8, S7, S6, BT, B36, G/S, Pyr, S5, B60, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.748" /TUlongSig="SigK" /TUlongPSig="0.98" /label="S421" CDS complement(1175492..1175809) /gene="cotW" /locus_tag="BSU_11770" /old_locus_tag="BSU11770" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8509331, 19304857, 21665972, 25872412" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8509331, 19304857, 21665972, 25872412; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (outemost layer)" /protein_id="NP_389059.1" /db_xref="EnsemblGenomes-Gn:BSU11770" /db_xref="EnsemblGenomes-Tr:CAB13034" /db_xref="GOA:Q08310" /db_xref="SubtiList:BG10497" /db_xref="UniProtKB/Swiss-Prot:Q08310" /translation="MSDNDKFKEELAKLPEVDPMTKMLVQNIFSKHGVTKDKMKKVSD EEKEMLLNLVKDLQAKSQALIENQKKKKEEAAAQEQKNTKPLSRREQLIEQIRQRRKN DNN*" /label="cotW CDS" gene complement(1175492..1175809) /gene="cotW" /locus_tag="BSU_11770" /old_locus_tag="BSU11770" /label="cotW gene" CDS complement(1175850..1176236) /gene="cotV" /locus_tag="BSU_11780" /old_locus_tag="BSU11780" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7519271, 8509331" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7519271, 8509331; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (insoluble fraction)" /protein_id="NP_389060.1" /db_xref="EnsemblGenomes-Gn:BSU11780" /db_xref="EnsemblGenomes-Tr:CAB13035" /db_xref="GOA:Q08309" /db_xref="InterPro:IPR011428" /db_xref="SubtiList:BG10496" /db_xref="UniProtKB/Swiss-Prot:Q08309" /translation="MSFEEKVESLHPAIFEQLSSEFEQQIEVIDCENITIDTSHITAA LSIQAFVTTMIIVATQLVIADEDLADAVASEILILDSSQIKKRTIIKIINSRNIKITL SADEIITFVQILLQVLNSILSELDVL*" /label="cotV CDS" gene complement(1175850..1176236) /gene="cotV" /locus_tag="BSU_11780" /old_locus_tag="BSU11780" /label="cotV gene" promotor_-35 1176232..1176236 /Source="Nicolas_upshift_promotors" /id="U951" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.005994005994006" /xcortree=1245 /SigmaFactorBS="ttgctcaaatattgcagggtgcagggattcgactttttcttc aaatGACATaaccttcACTCCTTTCTTATCCatactctatataatgcaaatggggtgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1176244..1176258 /Source="Nicolas_upshift_promotors" /id="U951" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.005994005994006" /xcortree=1245 /SigmaFactorBS="ttgctcaaatattgcagggtgcagggattcgactttttcttc aaatGACATaaccttcACTCCTTTCTTATCCatactctatataatgcaaatggggtgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1176246 /Source="Nicolas_upshifts" /id="U951" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.005994005994006" /xcortree=1245 /SigmaFactorBS="ttgctcaaatattgcagggtgcagggattcgactttttcttc aaatGACATaaccttcACTCCTTTCTTATCCatactctatataatgcaaatggggtgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1176256..1176275) /Source="Nicolas_upshift_promotors" /id="U952" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.748251748251748" /psig="0.748251748251748" /xcortree=1351 /SigmaFactorBS="catgaattgtatcttgtccggcagaaaattggttatttttat taTtCcGctctgcaccccattTGCATTATATAGAGTATGGAtaagaaaggagtgaagg t" /listShort="cotV, cotW, S421, cotX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1176278) /Source="Nicolas_upshifts" /id="U952" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.748251748251748" /psig="0.748251748251748" /xcortree=1351 /SigmaFactorBS="catgaattgtatcttgtccggcagaaaattggttatttttat taTtCcGctctgcaccccattTGCATTATATAGAGTATGGAtaagaaaggagtgaagg t" /listShort="cotV, cotW, S421, cotX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1176280..1176784) /Source="Nicolas_S_feature" /locus_tag="new_1252061_1252565_c" /HighExp="S8, S6, S7, BT, S5, B36, Pyr, C30, G/S, nit" /AntisenseName="yjcA" /AntisenseCor="0.69838474492609404" /AntisenseRegPval="-39.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.98" /TUlongSig="NA" /TUlongPSig="NA" /label="S422" promotor_-35 1176333..1176338 /Source="Nicolas_upshift_promotors" /id="U953" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1132 /SigmaFactorBS="aataaaaataaccaattttctgccggacaagatacaaTTCAT GaagaatagggttttgGCATATATGTGAAGGGATCatgattggcaaaggagtgaacga g" /listShort="yjcA, S423" /listLong="yjzK, yjcZ, S424, spoVIF, S425" /label="promotor_-35" promotor_-10 1176354..1176372 /Source="Nicolas_upshift_promotors" /id="U953" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1132 /SigmaFactorBS="aataaaaataaccaattttctgccggacaagatacaaTTCAT GaagaatagggttttgGCATATATGTGAAGGGATCatgattggcaaaggagtgaacga g" /listShort="yjcA, S423" /listLong="yjzK, yjcZ, S424, spoVIF, S425" /label="promotor_-10" upshifts 1176356 /Source="Nicolas_upshifts" /id="U953" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1132 /SigmaFactorBS="aataaaaataaccaattttctgccggacaagatacaaTTCAT GaagaatagggttttgGCATATATGTGAAGGGATCatgattggcaaaggagtgaacga g" /listShort="yjcA, S423" /listLong="yjzK, yjcZ, S424, spoVIF, S425" /label="upshifts" CDS 1176396..1176752 /gene="yjcA" /locus_tag="BSU_11790" /old_locus_tag="BSU11790" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523132, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523132, 15849754, 16850406; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protein" /protein_id="NP_389061.1" /db_xref="EnsemblGenomes-Gn:BSU11790" /db_xref="EnsemblGenomes-Tr:CAB13036" /db_xref="GOA:O31623" /db_xref="InterPro:IPR010773" /db_xref="SubtiList:BG13154" /db_xref="UniProtKB/Swiss-Prot:O31623" /translation="MVINGLTIVLLSLAVFRLARLLVFDTIMAPLRSLFHEEKEEKDA DGNIETYIVIKGTGVRAFIGELLSCYWCTGVWCAGFLILCQAVIPQAAQWLILLLAIA GLAGIIETLVSKWLQE*" /label="yjcA CDS" gene 1176396..1176752 /gene="yjcA" /locus_tag="BSU_11790" /old_locus_tag="BSU11790" /label="yjcA gene" promotor_-35 1176762..1176771 /Source="Nicolas_upshift_promotors" /id="U955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1353 /SigmaFactorBS="gctcgtatcaaaatggctgcaagaataaggcgttaccACCAG CAACTttctgtcagaataCGCATAAAGTAGCATATAtgacataaggaaaggaagggga c" /listShort="S423, yjzK" /listLong="yjcZ, S424, spoVIF, S425" /label="promotor_-35" promotor_-10 complement(1176769..1176788) /Source="Nicolas_upshift_promotors" /id="U954" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1256 /SigmaFactorBS="atgatgctgattcatttttgtccccttcctttcCTTATGTCA TatatgctactttaTGCGTATTCTGACAGAAAGTtgctggtggtaacgccttattctt g" /listShort="S422" /listLong="cotV, cotW, S421, cotX" /label="promotor_-10" CDS complement(1176777..1177010) /locus_tag="BSU_11798" /old_locus_tag="BSU11798" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="protein remnant" /db_xref="PSEUDO:SOX90549.1" /translation="MLSETASLKKQKTGVLRFLCQAIEAFSFYFRTRSLSFLSFLIDT MNLYMEIFGKVYDADSFLSPSFPYVIYATLCVF*" /label="protein remnant CDS" gene complement(1176777..1177010) /locus_tag="BSU_11798" /old_locus_tag="BSU11798" /pseudo /label="gene" upshifts complement(1176784) /Source="Nicolas_upshifts" /id="U954" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1256 /SigmaFactorBS="atgatgctgattcatttttgtccccttcctttcCTTATGTCA TatatgctactttaTGCGTATTCTGACAGAAAGTtgctggtggtaacgccttattctt g" /listShort="S422" /listLong="cotV, cotW, S421, cotX" /label="upshifts" S_feature 1176785..1176971 /Source="Nicolas_S_feature" /locus_tag="new_1252566_1252752" /HighExp="S8, S6, S7, BT, S5, B36, S4, S3, G/S, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.26970100000000002" /TUshortSig="SigK, SigEF" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S423" promotor_-10 1176785..1176802 /Source="Nicolas_upshift_promotors" /id="U955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1353 /SigmaFactorBS="gctcgtatcaaaatggctgcaagaataaggcgttaccACCAG CAACTttctgtcagaataCGCATAAAGTAGCATATAtgacataaggaaaggaagggga c" /listShort="S423, yjzK" /listLong="yjcZ, S424, spoVIF, S425" /label="promotor_-10" upshifts 1176785 /Source="Nicolas_upshifts" /id="U955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1353 /SigmaFactorBS="gctcgtatcaaaatggctgcaagaataaggcgttaccACCAG CAACTttctgtcagaataCGCATAAAGTAGCATATAtgacataaggaaaggaagggga c" /listShort="S423, yjzK" /listLong="yjcZ, S424, spoVIF, S425" /label="upshifts" promotor_-35 complement(1176802..1176811) /Source="Nicolas_upshift_promotors" /id="U954" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1256 /SigmaFactorBS="atgatgctgattcatttttgtccccttcctttcCTTATGTCA TatatgctactttaTGCGTATTCTGACAGAAAGTtgctggtggtaacgccttattctt g" /listShort="S422" /listLong="cotV, cotW, S421, cotX" /label="promotor_-35" downshifts complement(1176828) /Source="Nicolas_upshifts" /id="D643" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="3.12564" /MaxDrop="4.58782" /score="-6.14331629" /energy="-6.8" /TU="NA" /idTUdmin="U954" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" downshifts 1176928 /Source="Nicolas_upshifts" /id="D644" /incds=0 /nref=3 /ntot=32 /MaxReadThrough="5.73879" /MaxDrop="3.6919" /score="33.8150878" /energy="-6.8" /TU="U953,U955" /idTUdmin="U953" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" upshifts complement(1176982) /Source="Nicolas_upshifts" /id="U956" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.284715284715285" /psig="0.032967032967033" /xcortree=768 /SigmaFactorBS="ctcattcacttttatccccccgcttatgatatatgctgagcg agaCCGCCTCGttaaaaaaacaaaaaaccggagttctccggtttctttgccaggctat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1176983..1176992 /Source="Nicolas_upshift_promotors" /id="U957" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1288 /SigmaFactorBS="gaaaccggagaactccggttttttgttTTTTTAACGAggcgg tctcgctcAGCATATATCATAAGCGGGGggataaaagtgaatgagtttgaaaaatgga t" /listShort="yjzK, yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1176990..1176997) /Source="Nicolas_upshift_promotors" /id="U956" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.284715284715285" /psig="0.032967032967033" /xcortree=768 /SigmaFactorBS="ctcattcacttttatccccccgcttatgatatatgctgagcg agaCCGCCTCGttaaaaaaacaaaaaaccggagttctccggtttctttgccaggctat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1177006..1177025 /Source="Nicolas_upshift_promotors" /id="U957" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1288 /SigmaFactorBS="gaaaccggagaactccggttttttgttTTTTTAACGAggcgg tctcgctcAGCATATATCATAAGCGGGGggataaaagtgaatgagtttgaaaaatgga t" /listShort="yjzK, yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1177016 /Source="Nicolas_upshifts" /id="U957" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1288 /SigmaFactorBS="gaaaccggagaactccggttttttgttTTTTTAACGAggcgg tctcgctcAGCATATATCATAAGCGGGGggataaaagtgaatgagtttgaaaaatgga t" /listShort="yjzK, yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="upshifts" CDS 1177034..1177240 /gene="yjzK" /locus_tag="BSU_11799" /old_locus_tag="BSU11799" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097704.1" /db_xref="EnsemblGenomes-Gn:BSU11799" /db_xref="EnsemblGenomes-Tr:CAX52594" /db_xref="UniProtKB/Swiss-Prot:C0H3Y7" /translation="MNEFEKWIEGRYEPHEQKQKEHEDTMGSIRKDLDAFDKAGLEFE DEIEELAEKTEALLKKHQAQYDQS*" /label="yjzK CDS" gene 1177034..1177240 /gene="yjzK" /locus_tag="BSU_11799" /old_locus_tag="BSU11799" /label="yjzK gene" CDS 1177077..1177292 /gene="yjcB" /locus_tag="BSU_11800" /old_locus_tag="BSU11800" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523132" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523132; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protein" /protein_id="YP_009513951.1" /translation="MNKSKKSMKTRWAVSEKTWMHLIKPVWNLKMRLKSWLKKRRPYL KNIKLNMINRKSANALCEYPSRSQQLT*" /label="yjcB CDS" gene 1177077..1177292 /gene="yjcB" /locus_tag="BSU_11800" /old_locus_tag="BSU11800" /label="yjcB gene" promotor_-35 1177264..1177273 /Source="Nicolas_upshift_promotors" /id="U958" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1409 /SigmaFactorBS="tcaatcgtaaatccgcaaacgccctatgcgaatATCCAAGCC GatcccagcagctCACATAGTGTATAGAGAGTAaaggaggtgcttatctatgggcttt g" /listShort="yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1177286..1177305 /Source="Nicolas_upshift_promotors" /id="U958" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1409 /SigmaFactorBS="tcaatcgtaaatccgcaaacgccctatgcgaatATCCAAGCC GatcccagcagctCACATAGTGTATAGAGAGTAaaggaggtgcttatctatgggcttt g" /listShort="yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1177291 /Source="Nicolas_upshifts" /id="U958" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1409 /SigmaFactorBS="tcaatcgtaaatccgcaaacgccctatgcgaatATCCAAGCC GatcccagcagctCACATAGTGTATAGAGAGTAaaggaggtgcttatctatgggcttt g" /listShort="yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1177298..1177312) /Source="Nicolas_upshift_promotors" /id="U959" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=690 /SigmaFactorBS="gccataacagccgccgccgtagccgccgccgaatccgtatcc aaagCCCATagataagcaCCTCCTTTACTCTCTatacactatgtgagctgctgggatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1177312) /Source="Nicolas_upshifts" /id="U959" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=690 /SigmaFactorBS="gccataacagccgccgccgtagccgccgccgaatccgtatcc aaagCCCATagataagcaCCTCCTTTACTCTCTatacactatgtgagctgctgggatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1177322..1177326) /Source="Nicolas_upshift_promotors" /id="U959" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=690 /SigmaFactorBS="gccataacagccgccgccgtagccgccgccgaatccgtatcc aaagCCCATagataagcaCCTCCTTTACTCTCTatacactatgtgagctgctgggatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1177322..1177471 /gene="yjcZ" /locus_tag="BSU_11809" /old_locus_tag="BSU11809" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14523132, 20156992, 21670523; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative type I toxin" /protein_id="YP_003097705.1" /db_xref="EnsemblGenomes-Gn:BSU11809" /db_xref="EnsemblGenomes-Tr:CAX52595" /db_xref="GOA:C0H3Y8" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3Y8" /translation="MGFGYGFGGGYGGGCYGGYAGGYGGGYGSTFVLLVVLFILLIIV GASFF*" /label="yjcZ CDS" gene 1177322..1177471 /gene="yjcZ" /locus_tag="BSU_11809" /old_locus_tag="BSU11809" /label="yjcZ gene" downshifts 1177412 /Source="Nicolas_upshifts" /id="D645" /incds=0 /nref=4 /ntot=29 /MaxReadThrough="8.16203" /MaxDrop="4.48861" /score="1.53429015" /energy="-22.4" /TU="U957,U958" /idTUdmin="U955" /TUdmin=110 /isTUend="FALSE" /label="downshifts" S_feature 1177472..1177603 /Source="Nicolas_S_feature" /locus_tag="new_1253253_1253384" /HighExp="S7, BT, S8, B36, S6, G/S, Pyr, B60, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigK" /TUshortPSig="1, 0.971" /TUlongSig="SigK, SigEF" /TUlongPSig="0.999, 1" /label="S424" CDS 1177604..1177858 /gene="spoVIF" /locus_tag="BSU_11810" /old_locus_tag="BSU11810" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523132, 14702409, 20435725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523132, 14702409, 20435725; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protein needed for heat resistance" /protein_id="NP_389063.2" /db_xref="EnsemblGenomes-Gn:BSU11810" /db_xref="EnsemblGenomes-Tr:CAB13038" /db_xref="GOA:O31625" /db_xref="InterPro:IPR025942" /db_xref="SubtiList:BG13156" /db_xref="UniProtKB/Swiss-Prot:O31625" /translation="MDNQFFKNIEKKTGVKMQDVMNLAGSLQNANFKDENTVRSVINR VAQMANRRVPKELEDKIVESITSGKEKLDFGTISKMMDNK*" /label="spoVIF CDS" gene 1177604..1177858 /gene="spoVIF" /locus_tag="BSU_11810" /old_locus_tag="BSU11810" /label="spoVIF gene" downshifts 1177843 /Source="Nicolas_upshifts" /id="D646" /incds=0 /nref=40 /ntot=79 /MaxReadThrough="5.66609" /MaxDrop="5.8411" /score="7.68851688" /energy="-10.7" /TU="U957,U958" /idTUdmin="U955" /TUdmin=541 /isTUend="FALSE" /label="downshifts" downshifts complement(1177862) /Source="Nicolas_upshifts" /id="D647" /incds=0 /nref=3 /ntot=9 /MaxReadThrough="3.12148" /MaxDrop="4.34051" /score="24.4726468" /energy="-14.3" /TU="NA" /idTUdmin="U961" /TUdmin=88 /isTUend="FALSE" /label="downshifts" S_feature 1177888..1178988 /Source="Nicolas_S_feature" /locus_tag="new_1253669_1254769" /HighExp="S8, S6, S7, B36, S5, C30, BT, dia15, Diami, H2O2" /AntisenseName="yjcD" /AntisenseCor="-0.210610370451118" /AntisenseRegPval="-3.3" /CDS_PredictionProba="0.18426200000000001" /TUshortSig="SigK, SigK" /TUshortPSig="1, 0.971" /TUlongSig="SigK, SigEF" /TUlongPSig="0.999, 1" /label="S425" CDS complement(1177932..1180211) /gene="yjcD" /locus_tag="BSU_11820" /old_locus_tag="BSU11820" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544244, 16014871, 17114254, 22933559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent DNA helicase (sporulationassociated)" /protein_id="NP_389064.3" /db_xref="EnsemblGenomes-Gn:BSU11820" /db_xref="EnsemblGenomes-Tr:CAB13039" /db_xref="GOA:O31626" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="SubtiList:BG13157" /db_xref="UniProtKB/Swiss-Prot:O31626" /translation="MKCARLNDRIIHLHTYSREHYQFLFEEGIKGHLFCSHCGKPVLL RLNIADPPEFIHRQPGDFPACEEACEPKPSKEGKKEDDQESGVIRLPKGKAIAADPSP AVTEWHRPRSIKPGTPFVPKTIEPDTSLFPSVGLNTDQLKAVTETEGPLLVLAGAGSG KTRVLTARAAHMIEHLGIPPENMLLVTFTTKAVAEMKERMANQYGLQPAKVRRIVTGT FHSLFYKILYHSNSAKWNGEHLLKMEWQREQYIKKALYEEGIDEKESPVDQALQQIGF WKNTYVPNERIPLKDEWEKQVYRLYEHYERQKKEHSQFDFDDMASACYELFIERPDLL EQYQSRFTYILIDEFQDINPVQYKIMQMLASPEQNLCCVGDDDQSIYAFRGSNPSFIL DFQKDYPGAKTIYLTANYRSTHPIVSSADIVVKKNKNRYAKTLEAARDDIQVPVLFYP YDEEEEATMVVSDIKEKIQNGASPEDFAVLYRTNSGGRAIYERLHQSSIPYTADRGVQ SFYSRRIVRQILAYLYASQNEDDTEAIKHLLPALFLKQSALNTLKALSITEDCTMIKA LAKLPDLKPFQLDKIKKIVPFFASLRTMKPVEAITFAEGKMGFSEYLKKRGNEGNKLE KGSDDLRDIKVVAKKFKTIPDFLAHVDHMRAAEKNRTDEHGVQLMTIHRSKGLEFKTV YVLGTVDGSIPHDFSLETARKGDEAALEEERRLLYVAMTRAKQHLYLSCPANRRGKTA NRSRFLYPLLQKARQPLHH*" /label="yjcD CDS" gene complement(1177932..1180211) /gene="yjcD" /locus_tag="BSU_11820" /old_locus_tag="BSU11820" /label="yjcD gene" downshifts complement(1177950) /Source="Nicolas_upshifts" /id="D648" /incds=0 /nref=61 /ntot=171 /MaxReadThrough="2.59869" /MaxDrop="4.36061" /score="24.4726468" /energy="-14.3" /TU="NA" /idTUdmin="U961" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1180086..1180260) /Source="Nicolas_S_feature" /locus_tag="new_1255867_1256041_c" /HighExp="G180, G135, G150, H2O2, Paraq, Oxctl, LBGexp, dia15, dia0, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S426" promotor_-35 1180139..1180147 /Source="Nicolas_upshift_promotors" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1180158..1180176 /Source="Nicolas_upshift_promotors" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1180162..1180297 /Source="Nicolas_S_feature" /locus_tag="new_1255943_1256078" /HighExp="S4, S5, S3, S6, S7, S8, M9-stat, T4.0H, T3.0H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S427" upshifts 1180162 /Source="Nicolas_upshifts" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1180248..1180267) /Source="Nicolas_upshift_promotors" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1180259) /Source="Nicolas_upshifts" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1180275..1180281 /Source="Nicolas_upshift_promotors" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1180283..1180287) /Source="Nicolas_upshift_promotors" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1180296..1180314 /Source="Nicolas_upshift_promotors" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1180299 /Source="Nicolas_upshifts" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="upshifts" CDS 1180328..1180582 /gene="yjzE" /locus_tag="BSU_11839" /old_locus_tag="BSU11839" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11976315, 23155385" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097706.1" /db_xref="EnsemblGenomes-Gn:BSU11839" /db_xref="EnsemblGenomes-Tr:CAX52596" /db_xref="UniProtKB/Swiss-Prot:C0H3Y9" /translation="MIYAGQIQNQQYAQYANRTIGHKQDYAGTEKISYVPFQRVYKEL EKQQENQTAAERKVNEMKRKRSLYKRLREKGMGTYINRYV*" /label="yjzE CDS" gene 1180328..1180582 /gene="yjzE" /locus_tag="BSU_11839" /old_locus_tag="BSU11839" /label="yjzE gene" downshifts 1180558 /Source="Nicolas_upshifts" /id="D649" /incds=0 /nref=101 /ntot=248 /MaxReadThrough="3.69482" /MaxDrop="7.80206" /score="5.37568515" /energy="-6.1" /TU="U962" /idTUdmin="U960" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1180648) /Source="Nicolas_upshifts" /id="D650" /incds=0 /nref=78 /ntot=283 /MaxReadThrough="3.21062" /MaxDrop="7.8562" /score="-4.05705392" /energy="-6.1" /TU="U963" /idTUdmin="U963" /TUdmin="-36" /isTUend="FALSE" /label="downshifts" CDS complement(1180655..1181077) /gene="yjcF" /locus_tag="BSU_11840" /old_locus_tag="BSU11840" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389066.1" /db_xref="EnsemblGenomes-Gn:BSU11840" /db_xref="EnsemblGenomes-Tr:CAB13041" /db_xref="GOA:O31628" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1Q2Y" /db_xref="SubtiList:BG13159" /db_xref="UniProtKB/Swiss-Prot:O31628" /translation="MKAVIAKNEEQLKDAFYVREEVFVKEQNVPAEEEIDELENESEH IVVYDGEKPVGAGRWRMKDGYGKLERICVLKSHRSAGVGGIIMKALEKAAADGGASGF ILNAQTQAVPFYKKHGYRVLSEKEFLDAGIPHLQMMKD*" /label="yjcF CDS" gene complement(1180655..1181077) /gene="yjcF" /locus_tag="BSU_11840" /old_locus_tag="BSU11840" /label="yjcF gene" CDS complement(1181081..1181596) /gene="yjcG" /locus_tag="BSU_11850" /old_locus_tag="BSU11850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12466548, 16511078, 17012785, 18473364, 25643072; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA ligase or phosphoesterase" /protein_id="NP_389067.1" /db_xref="EnsemblGenomes-Gn:BSU11850" /db_xref="EnsemblGenomes-Tr:CAB13042" /db_xref="GOA:O31629" /db_xref="InterPro:IPR009097" /db_xref="InterPro:IPR022932" /db_xref="PDB:2D4G" /db_xref="SubtiList:BG13160" /db_xref="UniProtKB/Swiss-Prot:O31629" /translation="MKYGIVLFPSKKLQDLANSYRKRYDPSYSLIPPHLTLRASFECA EEKADQLVSHLRNIAKESHPLVLKMTKYSSFAPVNNVIYIKAEPTEELKTLNEKLYTG VLAGEQEYNFVPHVTVGQNLSDDEHSDVLGQLKMQEVSHEEIVDRFHLLYQLENGSWT VYETFLLGRGE*" /label="yjcG CDS" gene complement(1181081..1181596) /gene="yjcG" /locus_tag="BSU_11850" /old_locus_tag="BSU11850" /label="yjcG gene" CDS complement(1181633..1182355) /gene="yjcH" /locus_tag="BSU_11860" /old_locus_tag="BSU11860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20941576; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative stress-related hydrolase" /protein_id="NP_389068.1" /db_xref="EnsemblGenomes-Gn:BSU11860" /db_xref="EnsemblGenomes-Tr:CAB13043" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13161" /db_xref="UniProtKB/Swiss-Prot:O31630" /translation="MAPKNGTVQEKKFFSKELNEEMTLLVYLPSNYSPLYKYHVIIAQ DGHDYFRLGRIGRQVEELLSKREIDRSIIIGVPYKDVKERRNTYHPEGSKFSAYKRFI AHELVPFADDEYPTYQIGYGRTLIGDSLGATVSLMTALDYPNMFGNIIMQSPYVDKHV LEAVKQSDDIKHLSIYHQIGTKETDVHTTDGNILDFTEPNRELKQLLEKKLSDYDFEP FDGDHKWTYWQPLITPALKKML*" /label="yjcH CDS" gene complement(1181633..1182355) /gene="yjcH" /locus_tag="BSU_11860" /old_locus_tag="BSU11860" /label="yjcH gene" misc_feature complement(1182394..1182413) /Source="Nicolas_upshift_promotors" /id="U963" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2938 /SigmaFactorBS="tttatttcaacacttttttcttcgtgtgccgaaccgtttaaa gagagaaatttctaataattCATGGTACAATAATTGAAAAtgcaagaaagtatagtga t" /listShort="yjcH, yjcG, yjcF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1182415) /Source="Nicolas_upshifts" /id="U963" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2938 /SigmaFactorBS="tttatttcaacacttttttcttcgtgtgccgaaccgtttaaa gagagaaatttctaataattCATGGTACAATAATTGAAAAtgcaagaaagtatagtga t" /listShort="yjcH, yjcG, yjcF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1182464..1182471 /Source="Nicolas_upshift_promotors" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1182486..1182505 /Source="Nicolas_upshift_promotors" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1182490 /Source="Nicolas_upshifts" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1182523..1182643 /gene="mswA" /locus_tag="BSU_misc_RNA_15" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswA RNA" gene 1182523..1182643 /gene="mswA" /locus_tag="BSU_misc_RNA_15" /label="mswA gene" downshifts 1182648 /Source="Nicolas_upshifts" /id="D651" /incds=0 /nref=8 /ntot=59 /MaxReadThrough="7.71668" /MaxDrop="5.0477" /score="31.1477774" /energy="-15.2" /TU="U964" /idTUdmin="U962" /TUdmin=2024 /isTUend="FALSE" /label="downshifts" CDS 1182711..1183832 /gene="metI" /locus_tag="BSU_11870" /old_locus_tag="BSU11870" /EC_number="2.5.1.49" /EC_number="2.5.1.48" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11832514, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11832514, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine gamma-synthase and O-acetylhomoserine thiolyase" /protein_id="NP_389069.1" /db_xref="EnsemblGenomes-Gn:BSU11870" /db_xref="EnsemblGenomes-Tr:CAB13044" /db_xref="GOA:O31631" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13162" /db_xref="UniProtKB/Swiss-Prot:O31631" /translation="MSQHVETKLAQIGNRSDEVTGTVSAPIYLSTAYRHRGIGESTGF DYVRTKNPTRQLVEDAIANLENGARGLAFSSGMAAIQTIMALFKSGDELIVSSDLYGG TYRLFENEWKKYGLTFHYDDFSDEDCLRSKITPNTKAVFVETPTNPLMQEADIEHIAR ITKEHGLLLIVDNTFYTPVLQRPLELGADIVIHSATKYLGGHNDLLAGLVVVKDERLG EEMFQHQNAIGAVLPPFDSWLLMRGMKTLSLRMRQHQANAQELAAFLEEQEEISDVLY PGKGGMLSFRLQKEEWVNPFLKALKTICFAESLGGVESFITYPATQTHMDIPEEIRIA NGVCNRLLRFSVGIEHAEDLKEDLKQALCQVKEGAVSFE*" /label="metI CDS" gene 1182711..1183832 /gene="metI" /locus_tag="BSU_11870" /old_locus_tag="BSU11870" /label="metI gene" CDS 1183825..1184997 /gene="metC" /locus_tag="BSU_11880" /old_locus_tag="BSU11880" /EC_number="4.4.1.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11832514, 11948165, 15760717" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11832514, 11948165, 15760717; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine beta-lyase" /protein_id="NP_389070.1" /db_xref="EnsemblGenomes-Gn:BSU11880" /db_xref="EnsemblGenomes-Tr:CAB13045" /db_xref="GOA:O31632" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13163" /db_xref="UniProtKB/Swiss-Prot:O31632" /translation="MSKHNWTLETQLVHNPFKTDGGTGAVSVPIQHASTFHQSSFEEF GAYDYSRSGTPTRTALEETIAALEGGTRGFAFSSGMAAISTAFLLLSQGDHVLVTEDV YGGTFRMVTEVLTRFGIEHTFVDMTDRNEVARSIKPNTKVIYMETPSNPTLGITDIKA VVQLAKENGCLTFLDNTFMTPALQRPLDLGVDIVLHSATKFLSGHSDVLSGLAAVKDE ELGKQLYKLQNAFGAVLGVQDCWLVLRGLKTLQVRLEKASQTAQRLAEFFQKHPAVKR VYYPGLADHPGAETHKSQSTGAGAVLSFELESKEAVKKLVENVSLPVFAVSLGAVESI LSYPATMSHAAMPKEEREKRGITDGLLRLSVGVEHADDLEHDFEQALKEIAPVSVR*" /label="metC CDS" gene 1183825..1184997 /gene="metC" /locus_tag="BSU_11880" /old_locus_tag="BSU11880" /label="metC gene" downshifts 1184980 /Source="Nicolas_upshifts" /id="D652" /incds=0 /nref=108 /ntot=205 /MaxReadThrough="4.73188" /MaxDrop="5.54268" /score="4.00424187" /energy="-9.2" /TU="U964" /idTUdmin="U964" /TUdmin="-1474" /isTUend="FALSE" /label="downshifts" misc_feature 1185014..1185032 /Source="Nicolas_upshift_promotors" /id="U965" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.671328671328671" /psig="0.671328671328671" /xcortree=2911 /SigmaFactorBS="gctgaaagaaattgctccagtttcggttcgttaaaaaagaag ccggggatAGTCCGGCTTCTTTTATTAttgttcgtcatcaggattcagaatcgcgagg a" /listShort="S428" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1185024 /Source="Nicolas_upshifts" /id="U965" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.671328671328671" /psig="0.671328671328671" /xcortree=2911 /SigmaFactorBS="gctgaaagaaattgctccagtttcggttcgttaaaaaagaag ccggggatAGTCCGGCTTCTTTTATTAttgttcgtcatcaggattcagaatcgcgagg a" /listShort="S428" /GFF_Attribute="listLong" /label="upshifts" S_feature 1185025..1186554 /Source="Nicolas_S_feature" /locus_tag="new_1260806_1262335" /HighExp="MG 5, MG t5, MG 10, BMM, GM 25, MG 15, Glu, GM 15, GM 45, GM 10" /AntisenseName="yjcK" /AntisenseCor="0.123731990206979" /AntisenseRegPval="-1.4" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.671, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S428" CDS complement(1185030..1185575) /gene="yjcK" /locus_tag="BSU_11890" /old_locus_tag="BSU11890" /EC_number="2.3.1.267" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2828880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribosomal-protein-alanine N-acetyltransferase" /protein_id="NP_389071.1" /db_xref="EnsemblGenomes-Gn:BSU11890" /db_xref="EnsemblGenomes-Tr:CAB13046" /db_xref="GOA:O31633" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13164" /db_xref="UniProtKB/Swiss-Prot:O31633" /translation="MLKGKTIYVRPLEVTDAEENLGLQSENRDFFEQFSMIRADDYYT VEGQRKRITEYQERLEKDEEYHFGIFTASDDRLIGTVSLFQIIRGALQTAFIGYFLDK AHNGKGIMTEAVRLVVDYAFHELKLHRIEAGVMPRNLGSMRVLEKAGFHKEGIARKNV KINGVWEDHQVLAILNPDDEQ*" /label="yjcK CDS" gene complement(1185030..1185575) /gene="yjcK" /locus_tag="BSU_11890" /old_locus_tag="BSU11890" /label="yjcK gene" downshifts complement(1185051) /Source="Nicolas_upshifts" /id="D653" /incds=0 /nref=14 /ntot=127 /MaxReadThrough="0.4032" /MaxDrop="4.23858" /score="-7.12102596" /energy="-7.3" /TU="NA" /idTUdmin="U966" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" CDS complement(1185645..1186835) /gene="yjcL" /locus_tag="BSU_11900" /old_locus_tag="BSU11900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein; possibly aquaporin-related" /protein_id="NP_389072.1" /db_xref="EnsemblGenomes-Gn:BSU11900" /db_xref="EnsemblGenomes-Tr:CAB13047" /db_xref="GOA:O31634" /db_xref="InterPro:IPR008537" /db_xref="SubtiList:BG13165" /db_xref="UniProtKB/Swiss-Prot:O31634" /translation="MHSLISSDDVWVLWGFIAVWAAVSIGLEQRFKWASAVSGAIIAL AGAMVFTNVGVLPVESPVYDTVWSYVVPLAIPLLLFQINVRQIFKESRRLLFIFLISS VGTVLGSILAFFLLKQHIPYLDKIGGMISASYIGGGVNFAAMAAKFETPGEYVSATVV ADNFMMALLFFILISIPALKWFQRHYAMPFEEKVKADGNSGNSAESYWKRKDISLKDI AFNAGAAFALVAVSMKVSGYFKSIFSHPLLTGTLGDQYLVLTSLTVLIIFLFPRFFER LNGSQELGTFLIYLFFVVIGIPADLRLIVTNAPLILLFVFIIAISNLAVSLAAGKLFR VRLEEILLAVNATVGGPTTAAAMAIAKGWRELVAPIMLVGTLGYLIGNYVGTFMGNWF SSFL*" /label="yjcL CDS" gene complement(1185645..1186835) /gene="yjcL" /locus_tag="BSU_11900" /old_locus_tag="BSU11900" /label="yjcL gene" promotor_-10 complement(1186861..1186880) /Source="Nicolas_upshift_promotors" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1186865) /Source="Nicolas_upshifts" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1186895..1186902) /Source="Nicolas_upshift_promotors" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1186929..1186936 /Source="Nicolas_upshift_promotors" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1186940 /Source="Nicolas_upshifts" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1186950..1186969 /Source="Nicolas_upshift_promotors" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="promotor_-10" tRNA 1187008..1187080 /gene="trnSL-Val2" /locus_tag="BSU_tRNA_83" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="valine tRNA (GAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Val2 tRNA" gene 1187008..1187080 /gene="trnSL-Val2" /locus_tag="BSU_tRNA_83" /label="trnSL-Val2 gene" promotor_-10 complement(1187022..1187039) /Source="Nicolas_upshift_promotors" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1187036) /Source="Nicolas_upshifts" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1187060..1187066) /Source="Nicolas_upshift_promotors" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1187070 /Source="Nicolas_upshifts" /id="D654" /incds=0 /nref=17 /ntot=80 /MaxReadThrough="4.64061" /MaxDrop="5.10012" /score="20.8247903" /energy="-9.1" /TU="U967" /idTUdmin="U965" /TUdmin=550 /isTUend="FALSE" /label="downshifts" S_feature complement(1187095..1187830) /Source="Nicolas_S_feature" /locus_tag="new_1262876_1263611_c" /HighExp="M9-stat, Lbstat, M0t90, Pyr, T0.30H, M40t90, C30, S1, LPhT, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S429" S_feature 1187115..1188763 /Source="Nicolas_S_feature" /locus_tag="new_1262896_1264544" /HighExp="Cold, C30, G135, G180, G150, Oxctl, Fru, HPh, Glu, UNK1" /AntisenseName="yjcM" /AntisenseCor="0.46809452811910301" /AntisenseRegPval="-15.3" /CDS_PredictionProba="0.27514300000000003" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S430" downshifts complement(1187124) /Source="Nicolas_upshifts" /id="D655" /incds=0 /nref=29 /ntot=192 /MaxReadThrough="1.23936" /MaxDrop="3.57085" /score="-4.98447688" /energy="-7.9" /TU="NA" /idTUdmin="U970" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1187832..1187920) /Source="Nicolas_S_feature" /locus_tag="new_1263613_1263701_c" /HighExp="aero, HPh, M0t45, SMM, dia0, GM 150, Mal, M/G, Mt0, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S431" downshifts complement(1187875) /Source="Nicolas_upshifts" /id="D656" /incds=0 /nref=34 /ntot=148 /MaxReadThrough="4.13737" /MaxDrop="4.5557" /score="11.73443" /energy="-14.2" /TU="U970" /idTUdmin="U970" /TUdmin="-751" /isTUend="FALSE" /label="downshifts" CDS complement(1187921..1189150) /gene="yjcM" /locus_tag="BSU_11910" /old_locus_tag="BSU11910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20011599" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389073.1" /db_xref="EnsemblGenomes-Gn:BSU11910" /db_xref="EnsemblGenomes-Tr:CAB13048" /db_xref="InterPro:IPR024301" /db_xref="SubtiList:BG13166" /db_xref="UniProtKB/Swiss-Prot:O31635" /translation="MKKELLASLVLCLSLSPLVSTNEVFAATTNKETKENVSITNEIG YEKVKDMLEQQKYDFEHNTPLAHPKESKLTDSDEGVLLYSALSKVDKQKFHEFTYDID DVKTSEKNNKLIVEAYITRNFVFGVEKVTTSLGDNIKLEIPKTTSNKQSSQSTNTSNL SFSQVKNSSNQLNVIPLSNSSKQLNVTQLNNSSSTLQYENDEEYSSDVKLDEFLKKYK QEVKNDDKEEVKSEDKPVSMNFNAANSNQLTVTATSVKGYSGYAAMKYAEKYALKPNK NYKYYKDKDCTNFVSQALRAGRMPYFKEWKPYTDAWVNAGAFRSYILKAGGIKMKTVS DTYSNVKLGDVYHYDYHNKIGLRYADGWMDHTAIVTSRANMKLYVSYHSTNRLNVPRE YVTSKEGGKRYVSSIRN*" /label="yjcM CDS" gene complement(1187921..1189150) /gene="yjcM" /locus_tag="BSU_11910" /old_locus_tag="BSU11910" /label="yjcM gene" downshifts complement(1188043) /Source="Nicolas_upshifts" /id="D657" /incds=1 /nref=4 /ntot=143 /MaxReadThrough="5.58558" /MaxDrop="3.45178" /score="11.73443" /energy="-14.2" /TU="U970" /idTUdmin="U970" /TUdmin="-919" /isTUend="FALSE" /label="downshifts" downshifts 1188720 /Source="Nicolas_upshifts" /id="D658" /incds=1 /nref=1 /ntot=48 /MaxReadThrough="3.19343" /MaxDrop="1.98614" /score="26.2462772" /energy="-24.7" /TU="NA" /idTUdmin="U967" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1189151..1189236) /Source="Nicolas_S_feature" /locus_tag="new_1264932_1265017_c" /HighExp="aero, SMM, T-3.40H, MG 150, Lbexp, SMMPr, GM 90, C90, nit, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S432" promotor_-35 1189191..1189198 /Source="Nicolas_upshift_promotors" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1189213..1189232 /Source="Nicolas_upshift_promotors" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1189222..1189241) /Source="Nicolas_upshift_promotors" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1189226 /Source="Nicolas_upshifts" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1189240) /Source="Nicolas_upshifts" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1189254..1189260) /Source="Nicolas_upshift_promotors" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1189276..1189596 /gene="yjcN" /locus_tag="BSU_11920" /old_locus_tag="BSU11920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389074.1" /db_xref="EnsemblGenomes-Gn:BSU11920" /db_xref="EnsemblGenomes-Tr:CAB13049" /db_xref="SubtiList:BG13167" /db_xref="UniProtKB/Swiss-Prot:O31636" /translation="MKKKTKIILSLLAALIVILIVLPVLSPVVFTASSEKGAIRHEIY KRGYPYQSYFAVLQKREGDNESGNLYYVNWLDWKDETGQTPHLCYSKKSSDGEYEVSC GTGP*" /label="yjcN CDS" gene 1189276..1189596 /gene="yjcN" /locus_tag="BSU_11920" /old_locus_tag="BSU11920" /label="yjcN gene" downshifts 1189606 /Source="Nicolas_upshifts" /id="D659" /incds=0 /nref=57 /ntot=233 /MaxReadThrough="3.73892" /MaxDrop="4.41989" /score="26.2462772" /energy="-24.7" /TU="U969" /idTUdmin="U967" /TUdmin=886 /isTUend="FALSE" /label="downshifts" S_feature 1189651..1189748 /Source="Nicolas_S_feature" /locus_tag="new_1265432_1265529" /HighExp="LoTm, B60, Cold, B36, T3.30H, T3.0H, T4.0H, T2.0H, Sw, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S433" CDS 1189749..1189880 /gene="yjzF" /locus_tag="BSU_11928" /old_locus_tag="BSU11928" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097707.1" /db_xref="EnsemblGenomes-Gn:BSU11928" /db_xref="EnsemblGenomes-Tr:CAX52597" /db_xref="UniProtKB/Swiss-Prot:C0H3Z0" /translation="MKQSKKKPSQKQHERLDRFWQQMMNTNMQTLRRGKGGAYKRRK* " /label="yjzF CDS" gene 1189749..1189880 /gene="yjzF" /locus_tag="BSU_11928" /old_locus_tag="BSU11928" /label="yjzF gene" CDS 1189896..1190069 /gene="yjzG" /locus_tag="BSU_11929" /old_locus_tag="BSU11929" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097708.1" /db_xref="EnsemblGenomes-Gn:BSU11929" /db_xref="EnsemblGenomes-Tr:CAX52598" /db_xref="UniProtKB/Swiss-Prot:C0H3Z1" /translation="MMKNGFAYKNGKLVNIFCGKEELYNELKAFLVKTFSINVKEVSR PSIYRRTKSKQLE*" /label="yjzG CDS" gene 1189896..1190069 /gene="yjzG" /locus_tag="BSU_11929" /old_locus_tag="BSU11929" /label="yjzG gene" CDS 1190106..1190567 /gene="yjcO" /locus_tag="BSU_11930" /old_locus_tag="BSU11930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative DNA binding protein; phage island" /protein_id="NP_389075.1" /db_xref="EnsemblGenomes-Gn:BSU11930" /db_xref="EnsemblGenomes-Tr:CAB13050" /db_xref="GOA:O31637" /db_xref="InterPro:IPR013324" /db_xref="SubtiList:BG13168" /db_xref="UniProtKB/Swiss-Prot:O31637" /translation="MTDQMIAWEIEEWIRDYKFMLREIKRLNRVLNKVDFISTKLTAT YGEEAGMPRGSAGVSQAELRQMDRRERRLHKYESIVHYLDNAMEHIEEEKHRIVYDCM MEGMSYTAIANHLDCSRDTIRKIKTAIIGNIVNKVKEANFLQYLNSFKSAV*" /label="yjcO CDS" gene 1190106..1190567 /gene="yjcO" /locus_tag="BSU_11930" /old_locus_tag="BSU11930" /label="yjcO gene" promotor_-35 1190538..1190545 /Source="Nicolas_upshift_promotors" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="promotor_-35" promotor_-10 1190560..1190579 /Source="Nicolas_upshift_promotors" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="promotor_-10" S_feature 1190568..1190808 /Source="Nicolas_S_feature" /locus_tag="new_1266349_1266589" /HighExp="LoTm, B60, Cold, B36, Diami, S8, dia15, C30, dia5, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.12525800000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S434" upshifts 1190568 /Source="Nicolas_upshifts" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="upshifts" promotor_-35 1190781..1190788 /Source="Nicolas_upshift_promotors" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1190802..1190820 /Source="Nicolas_upshift_promotors" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1190810 /Source="Nicolas_upshifts" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1190833..1191336 /gene="yjcP" /locus_tag="BSU_11940" /old_locus_tag="BSU11940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein: phage island" /protein_id="NP_389076.1" /db_xref="EnsemblGenomes-Gn:BSU11940" /db_xref="EnsemblGenomes-Tr:CAB13051" /db_xref="GOA:O31638" /db_xref="SubtiList:BG13169" /db_xref="UniProtKB/Swiss-Prot:O31638" /translation="MKKQKNNKKKNIEKRNIEKRNIEEKNNEDLEELENAIYTYHKKE LLAFFLEKTRIGHDKEEYKRFQSLLYKLDIECLEFAISRFSHIDIIHDHSKYVPAFIP LFAAYLTMFFNFYEKHWGALSFAAGTIAAIVWIIAVERKHRNQAISIMKIFEQVKERK VKDRSKD*" /label="yjcP CDS" gene 1190833..1191336 /gene="yjcP" /locus_tag="BSU_11940" /old_locus_tag="BSU11940" /label="yjcP gene" CDS 1191348..1191632 /gene="yjcQ" /locus_tag="BSU_11950" /old_locus_tag="BSU11950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389077.1" /db_xref="EnsemblGenomes-Gn:BSU11950" /db_xref="EnsemblGenomes-Tr:CAB13052" /db_xref="InterPro:IPR018597" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2HGC" /db_xref="SubtiList:BG13170" /db_xref="UniProtKB/Swiss-Prot:O31639" /translation="MNKDKLRYAILKEIFEGNTPLSENDIGVTEDQFDDAVNFLKREG YIIGVHYSDDRPHLYKLGPELTEKGENYLKENGTWSKAYKTIKEIKDWIK*" /label="yjcQ CDS" gene 1191348..1191632 /gene="yjcQ" /locus_tag="BSU_11950" /old_locus_tag="BSU11950" /label="yjcQ gene" downshifts 1191602 /Source="Nicolas_upshifts" /id="D660" /incds=0 /nref=215 /ntot=271 /MaxReadThrough="1.63272" /MaxDrop="7.26386" /score="22.0381158" /energy="-7.2" /TU="NA" /idTUdmin="U969" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1191634) /Source="Nicolas_upshifts" /id="U973" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.828171828171828" /psig="0.107892107892108" /xcortree=80 /SigmaFactorBS="tcctgagacttaccggaagcagtttacagggaacaaaaaaag caccCCGCaggatgctcttattatttaatccaatctttaatctctttaatggtcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1191645..1191648) /Source="Nicolas_upshift_promotors" /id="U973" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.828171828171828" /psig="0.107892107892108" /xcortree=80 /SigmaFactorBS="tcctgagacttaccggaagcagtttacagggaacaaaaaaag caccCCGCaggatgctcttattatttaatccaatctttaatctctttaatggtcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1191793..1192320 /gene="yjcR" /locus_tag="BSU_11960" /old_locus_tag="BSU11960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7489895, 7704261; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phage-related nucleic acid binding terminase small subunit; phage island" /protein_id="NP_389078.1" /db_xref="EnsemblGenomes-Gn:BSU11960" /db_xref="EnsemblGenomes-Tr:CAB13053" /db_xref="GOA:O31640" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR010332" /db_xref="SubtiList:BG13171" /db_xref="UniProtKB/Swiss-Prot:O31640" /translation="MAEKHIQAYKDYVKGMKYKDLAEKYGVSVNTIKSWKQRHGWERK KGAPIEKSVHTKKGGQPGNKNALGNNGGAPQKNQNAVTHGFFSKFLPEETLEIMEEIQ ERSPADMIWDQIQIQYAAILRAQKIMFVSDKEEMIKELKKKRSLISEVSEIEDGLVIS FSTWFRYRLYSETNT*" /label="yjcR CDS" gene 1191793..1192320 /gene="yjcR" /locus_tag="BSU_11960" /old_locus_tag="BSU11960" /label="yjcR gene" promotor_-35 1192467..1192472 /Source="Nicolas_upshift_promotors" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1192485..1192504 /Source="Nicolas_upshift_promotors" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1192488 /Source="Nicolas_upshifts" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="upshifts" CDS 1192494..1192811 /gene="yjcS" /locus_tag="BSU_11970" /old_locus_tag="BSU11970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389079.1" /db_xref="EnsemblGenomes-Gn:BSU11970" /db_xref="EnsemblGenomes-Tr:CAB13054" /db_xref="GOA:O31641" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:1Q8B" /db_xref="SubtiList:BG13172" /db_xref="UniProtKB/Swiss-Prot:O31641" /translation="MKSHKMMGGGISMHYITACLKIISDKDLNEIMKEFKKLEEETNK EEGCITFHAYPLEPSERKIMLWEIWENEEAVKIHFTKKHTIDVQKQELTEVEWLMKSN VND*" /label="yjcS CDS" gene 1192494..1192811 /gene="yjcS" /locus_tag="BSU_11970" /old_locus_tag="BSU11970" /label="yjcS gene" S_feature 1192812..1193047 /Source="Nicolas_S_feature" /locus_tag="new_1268593_1268828" /HighExp="dia5, H2O2, dia15, dia0, Lbexp, Lbtran, C90, Oxctl, S1, aero" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S435" CDS 1193048..1193803 /gene="yjdA" /locus_tag="BSU_11980" /old_locus_tag="BSU11980" /EC_number="1.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2243795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-carrier protein oxidoreductase; phage island" /protein_id="NP_389080.1" /db_xref="EnsemblGenomes-Gn:BSU11980" /db_xref="EnsemblGenomes-Tr:CAB13055" /db_xref="GOA:O31642" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13173" /db_xref="UniProtKB/Swiss-Prot:O31642" /translation="MSHSQEKIALITGASSQGDIGTAICRKLASQGIHIFFTHWNSDT AWIEEFQQEILRMGVRCEAMKIDLSDAHAAFTIHEKISDKLGYPSILINNAAHSASDN YVSLDAKSLDEHYAVNMRSNFLLCVEFARRFKKSNLISGRIINMTSGQDLGPLPGELA YAATKGAISAFTRSLSQELAPLGITVNAVNPGPTDSTWMTDEIRNFLSPKFPMGRIGT PDDAARMIAFLASDEAEWITGQIIHSEGGFIRG*" /label="yjdA CDS" gene 1193048..1193803 /gene="yjdA" /locus_tag="BSU_11980" /old_locus_tag="BSU11980" /label="yjdA gene" S_feature 1193804..1193891 /Source="Nicolas_S_feature" /locus_tag="new_1269585_1269672" /HighExp="C90, S1, dia0, dia5, Mt0, Lbexp, Gly, H2O2, Oxctl, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S436" downshifts 1193848 /Source="Nicolas_upshifts" /id="D661" /incds=0 /nref=89 /ntot=238 /MaxReadThrough="2.66489" /MaxDrop="5.39812" /score="-0.84766737" /energy="-14.2" /TU="NA" /idTUdmin="U974" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" S_feature complement(1193891..1193951) /Source="Nicolas_S_feature" /locus_tag="new_1269672_1269732_c" /HighExp="Lbstat, BI, BT, nit, S2, ferm, B60, B36, M0t90, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S437" downshifts complement(1193922) /Source="Nicolas_upshifts" /id="D662" /incds=0 /nref=80 /ntot=134 /MaxReadThrough="1.9707" /MaxDrop="7.43843" /score="-5.56180712" /energy="-14.2" /TU="NA" /idTUdmin="U975" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1193952..1194299) /gene="yjdB" /locus_tag="BSU_11990" /old_locus_tag="BSU11990" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16291680; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative exported protein; phage island" /protein_id="NP_389081.1" /db_xref="EnsemblGenomes-Gn:BSU11990" /db_xref="EnsemblGenomes-Tr:CAB13056" /db_xref="InterPro:IPR003343" /db_xref="InterPro:IPR008964" /db_xref="SubtiList:BG13174" /db_xref="UniProtKB/Swiss-Prot:O31643" /translation="MNFKKTVVSALSISALALSVSGVASAHEINSTPTEVKNISISPT HVIKIQDYNLPLKVGETYSVKNNSATRYWTDNQKVAEVDQNGLVTAKSKGKATITLFK GTAVFGKVYVTVY*" /label="yjdB CDS" gene complement(1193952..1194299) /gene="yjdB" /locus_tag="BSU_11990" /old_locus_tag="BSU11990" /label="yjdB gene" promotor_-10 complement(1194331..1194349) /Source="Nicolas_upshift_promotors" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1194344) /Source="Nicolas_upshifts" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1194346..1194802) /Source="Nicolas_S_feature" /locus_tag="new_1270127_1270583_c" /HighExp="T1.30H, T2.0H, T2.30H, T3.0H, M9-stat, T1.0H, Lbstat, T3.30H, M0t90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S438" promotor_-35 complement(1194360..1194368) /Source="Nicolas_upshift_promotors" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1194762..1194780 /Source="Nicolas_upshift_promotors" /id="U976" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.33966033966034" /psig="0.99100899100899" /xcortree=1564 /SigmaFactorBS="tttttccggaagcttcggtaaaaaacgaaacttttgtctcta tgatttTGTTTTATAATGTAAACGGtttcttatatagtatacttatactatcaatttg c" /listShort="manR" /listLong="manP, manA, S439, S440, yjdF, yjdI" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1194774 /Source="Nicolas_upshifts" /id="U976" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.33966033966034" /psig="0.99100899100899" /xcortree=1564 /SigmaFactorBS="tttttccggaagcttcggtaaaaaacgaaacttttgtctcta tgatttTGTTTTATAATGTAAACGGtttcttatatagtatacttatactatcaatttg c" /listShort="manR" /listLong="manP, manA, S439, S440, yjdF, yjdI" /label="upshifts" promotor_-10 complement(1194780..1194799) /Source="Nicolas_upshift_promotors" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1194802) /Source="Nicolas_upshifts" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1194813..1194820) /Source="Nicolas_upshift_promotors" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1194850..1196796 /gene="manR" /locus_tag="BSU_12000" /old_locus_tag="BSU12000" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10438772, 10960106, 23551403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438772, 10960106, 23551403; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional DNA-binding activator" /protein_id="NP_389082.2" /db_xref="EnsemblGenomes-Gn:BSU12000" /db_xref="EnsemblGenomes-Tr:CAB13057" /db_xref="GOA:O31644" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG13175" /db_xref="UniProtKB/Swiss-Prot:O31644" /translation="MEYINTRQKEILYLLLSEPDDYLVVQDFADRVQCSEKTIRNDLK VIEDYLNEHSHAQLIRKPGLGVYLHIEEQERTWLSQQLHTEHFSSRQRSDKERMLHIA YDLLMNPKPVSAKDIAARHFVNRSSIKKDLYAVEEWLKRFDLTLVSRQRLGLKVEGNE RNKRKALARISDLIHNTAFTSQFIKSKFLHYEVDFVTKEIKSLQKKHSLYFTDETFES LLLHTLLMVRRIKMKQPISLSPKEMAAVKKKKEYQWTFACLQRLEPVFAIRFPEEEAV YLTLHILGGKVRYPLQTEENLENAVLPKVVGHLINRVSELKMMDFHKDQDLINGLNIH LNTVLQRLSYDLSVANPMLNDIKKMYPYLFHLIIDVLEDINQTFDLHIPEEEAAYLTL HFQAAIERMQGSSETHKKAVIVCHMGIGMSQLLRTKIERKYHQIAVMACIAKADLKDY IKKHEDIDLVISTIALENITVPHIVVSPLLEPGEEKKLSAFIRQLGESHRQKQKTFQM LNNTTPFLVFLQQEAEHRYKLIEQLATALFEKGYVDKDYAVHAVMREKMSATNIGSGI AIPHANAKFIKQSAIAIATLKEPLEWGNEKVSLVFMLAVKHEDQTMTKQLFSELSYLS EQPAFVQKLTKETNVMTFLSHLDY*" /label="manR CDS" gene 1194850..1196796 /gene="manR" /locus_tag="BSU_12000" /old_locus_tag="BSU12000" /label="manR gene" downshifts 1196772 /Source="Nicolas_upshifts" /id="D663" /incds=0 /nref=3 /ntot=35 /MaxReadThrough="4.64475" /MaxDrop="3.79938" /score="28.4199725" /energy="-9.1" /TU="U976" /idTUdmin="U976" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" SCAR 1196826..1196827 /note="deletion occured in betwen marked nucleotides" /created_by="User" /label="IIG_Bs02" S_feature <1196827..1196925 /Source="Nicolas_S_feature" /locus_tag="new_1275640_1275738" /HighExp="Oxctl, Lbexp, Paraq, T0.30H, dia0, Diami, H2O2, dia5, Fru, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15168699999999999" /TUshortSig="SigA" /TUshortPSig="0.936" /TUlongSig="SigA" /TUlongPSig="0.991" /label="S439" promotor_-35 1196900..1196906 /Source="Nicolas_upshift_promotors" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1196921..1196940 /Source="Nicolas_upshift_promotors" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1196927..1196995 /Source="Nicolas_S_feature" /locus_tag="new_1275740_1275808" /HighExp="Oxctl, Lbexp, Paraq, T0.30H, dia0, Diami, dia5, Fru, H2O2, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 0.936" /TUlongSig="SigA" /TUlongPSig="0.991" /label="S440" upshifts 1196927 /Source="Nicolas_upshifts" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="upshifts" CDS 1196996..1197478 /gene="yjdF" /locus_tag="BSU_12030" /old_locus_tag="BSU12030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20139185" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389085.1" /db_xref="EnsemblGenomes-Gn:BSU12030" /db_xref="EnsemblGenomes-Tr:CAB13060" /db_xref="InterPro:IPR016787" /db_xref="SubtiList:BG13178" /db_xref="UniProtKB/Swiss-Prot:O31647" /translation="MSVTFPSSGCPSFFNIFYEEGIVMKLTIYYDGQFWVGVVEVVDN GKLRAFRHLFGKEPRDSEVLEFVHNQLLNMMAQAEQEGVRLQGRRQKKINPKRLQRQV SKELKNAGVTSKAQEAIKLELEARKQKKKQIMKEQREHVKEQRYMLKKQKAKKKHRGK *" /label="yjdF CDS" gene 1196996..1197478 /gene="yjdF" /locus_tag="BSU_12030" /old_locus_tag="BSU12030" /label="yjdF gene" downshifts 1197458 /Source="Nicolas_upshifts" /id="D664" /incds=0 /nref=220 /ntot=267 /MaxReadThrough="5.32805" /MaxDrop="7.35641" /score="7.68574519" /energy="-10.2" /TU="U978" /idTUdmin="U980" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1197524..1198030) /gene="yjdG" /locus_tag="BSU_12040" /old_locus_tag="BSU12040" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389086.1" /db_xref="EnsemblGenomes-Gn:BSU12040" /db_xref="EnsemblGenomes-Tr:CAB13061" /db_xref="GOA:O31648" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13179" /db_xref="UniProtKB/Swiss-Prot:O31648" /translation="MVLLETNRLRLQTIDIPLLDAASKQDHQAIKELGYETNGEWPNS DFFEAIPYFREILVKNNGTKGFDSWIIVKKDNYEIVGGTGFLGDPDENGMIEIGFATN KSHRRKGYCVEAAQKLINWALSRETVSRITARCEHDNLGSQKTLEKLGFILNHKSAEY KHWIYVTK*" /label="yjdG CDS" gene complement(1197524..1198030) /gene="yjdG" /locus_tag="BSU_12040" /old_locus_tag="BSU12040" /label="yjdG gene" downshifts complement(1197548) /Source="Nicolas_upshifts" /id="D665" /incds=0 /nref=13 /ntot=154 /MaxReadThrough="2.51872" /MaxDrop="4.09551" /score="15.8830125" /energy="-9.9" /TU="NA" /idTUdmin="U984" /TUdmin=7 /isTUend="TRUE" /label="downshifts" misc_feature complement(1198055..1198074) /Source="Nicolas_upshift_promotors" /id="U981" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig="0.775224775224775" /xcortree=679 /SigmaFactorBS="aattttttcatctttctctactgccaaggtaccagagaaaat tgttaTATGTTATCATTATTCCCAGtaaaaagaaaagaggattaaatatatggttctc c" /listShort="yjdG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1198061) /Source="Nicolas_upshifts" /id="U981" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig="0.775224775224775" /xcortree=679 /SigmaFactorBS="aattttttcatctttctctactgccaaggtaccagagaaaat tgttaTATGTTATCATTATTCCCAGtaaaaagaaaagaggattaaatatatggttctc c" /listShort="yjdG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1198063..1198248) /Source="Nicolas_S_feature" /locus_tag="new_1276876_1277061_c" /HighExp="S5, S4, S7, S6, S8, B36, LoTm, S3, B60, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.289238" /TUshortSig="SigEF, SigWXY" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S441" CDS complement(1198249..1198644) /gene="yjdH" /locus_tag="BSU_12050" /old_locus_tag="BSU12050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_389087.2" /db_xref="EnsemblGenomes-Gn:BSU12050" /db_xref="EnsemblGenomes-Tr:CAB13062" /db_xref="SubtiList:BG13180" /db_xref="UniProtKB/Swiss-Prot:O31649" /translation="MYHYFYGPALIPYFSHTHNPQRSPDFSERQRRREITLTVDGFVP PSSTEDLGDGFYSYAWTNQQVINPGEYLVCHLEGRDINVINGGFTPRDTAPLYAVASF PRRRNQWVIIIHNPVQTQRAISLYLIAKR*" /label="yjdH CDS" gene complement(1198249..1198644) /gene="yjdH" /locus_tag="BSU_12050" /old_locus_tag="BSU12050" /label="yjdH gene" promotor_-10 complement(1198667..1198685) /Source="Nicolas_upshift_promotors" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1198680) /Source="Nicolas_upshifts" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1198682..1199382) /Source="Nicolas_S_feature" /locus_tag="new_1277495_1278195_c" /HighExp="T0.30H, T1.0H, T-0.40H, T1.30H, T0.0H, S0, T2.0H, Salt, T2.30H, T-1.10H" /AntisenseName="yjdI" /AntisenseCor="-0.383915151906285" /AntisenseRegPval="-10.1" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S442" promotor_-35 complement(1198700..1198705) /Source="Nicolas_upshift_promotors" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1198788..1198795 /Source="Nicolas_upshift_promotors" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1198809..1198828 /Source="Nicolas_upshift_promotors" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1198820 /Source="Nicolas_upshifts" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="upshifts" CDS 1198873..1199352 /gene="trnE" /locus_tag="BSU_12060" /old_locus_tag="BSU12060" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22128149; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cys-tRNApro deacetylase; tRNA editing" /protein_id="NP_389088.1" /db_xref="EnsemblGenomes-Gn:BSU12060" /db_xref="EnsemblGenomes-Tr:CAB13063" /db_xref="GOA:O31650" /db_xref="InterPro:IPR004369" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG13181" /db_xref="UniProtKB/Swiss-Prot:O31650" /translation="MAKKMAKTNAVRLIEQQNISYEVLGYKTDGQPVDGISVAEKIGY SLKYVYKTLVAAAGTNHYYVFVVPVAEELDVKKAAKVTGEKKIEMIAMKELLAVTGYL RGGCSPIGMKKLFPTYIDASAETLDFIIVSAGKIGMQLKLAPQDLARSCDAAFAEIV* " /label="trnE CDS" gene 1198873..1199352 /gene="trnE" /locus_tag="BSU_12060" /old_locus_tag="BSU12060" /label="trnE gene" downshifts 1199351 /Source="Nicolas_upshifts" /id="D666" /incds=0 /nref=4 /ntot=100 /MaxReadThrough="2.68858" /MaxDrop="3.19616" /score="-5.52314972" /energy="-12.5" /TU="NA" /idTUdmin="U978" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1199392..1199586) /gene="yjzH" /locus_tag="BSU_12069" /old_locus_tag="BSU12069" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097709.1" /db_xref="EnsemblGenomes-Gn:BSU12069" /db_xref="EnsemblGenomes-Tr:CAX52599" /db_xref="InterPro:IPR025234" /db_xref="UniProtKB/Swiss-Prot:C0H3Z2" /translation="MKEYEFVRVELSTMRRRPKEDYQQIIHDYAKRGWRFVQIFAPSI DGYGAAAYFEIIFERDAEKA*" /label="yjzH CDS" gene complement(1199392..1199586) /gene="yjzH" /locus_tag="BSU_12069" /old_locus_tag="BSU12069" /label="yjzH gene" downshifts complement(1199427) /Source="Nicolas_upshifts" /id="D667" /incds=0 /nref=6 /ntot=144 /MaxReadThrough="7.83072" /MaxDrop="2.95935" /score="-6.07514027" /energy="-7" /TU="U984" /idTUdmin="U987" /TUdmin=220 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1199600..1199615) /Source="Nicolas_upshift_promotors" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1199616) /Source="Nicolas_upshifts" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1199627..1199636) /Source="Nicolas_upshift_promotors" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1199752..1200081) /gene="yjdJ" /locus_tag="BSU_12070" /old_locus_tag="BSU12070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389089.1" /db_xref="EnsemblGenomes-Gn:BSU12070" /db_xref="EnsemblGenomes-Tr:CAB13064" /db_xref="GOA:O31651" /db_xref="InterPro:IPR016508" /db_xref="InterPro:IPR025440" /db_xref="SubtiList:BG13182" /db_xref="UniProtKB/Swiss-Prot:O31651" /translation="MKGIFLVVQLGFSIMVFLFLAAVNWYQGSELVSDRFDWNYTAKL SKLLNGIDAVSSPKQISQLDFFIYSAKHYPVMSALMIISFLYVLAALFLLIYSVKCNK QEIHLDC*" /label="yjdJ CDS" gene complement(1199752..1200081) /gene="yjdJ" /locus_tag="BSU_12070" /old_locus_tag="BSU12070" /label="yjdJ gene" promotor_-10 complement(1200118..1200137) /Source="Nicolas_upshift_promotors" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1200131) /Source="Nicolas_upshifts" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1200133..1200700) /Source="Nicolas_S_feature" /locus_tag="new_1278946_1279513_c" /HighExp="S8, S6, nit, S7, ferm, S2, S5, M9-tran, M/G, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.987, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S443" promotor_-35 complement(1200152..1200157) /Source="Nicolas_upshift_promotors" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1200185..1200189 /Source="Nicolas_upshift_promotors" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1200205..1200224 /Source="Nicolas_upshift_promotors" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1200209..1200710 /Source="Nicolas_S_feature" /locus_tag="new_1279022_1279523" /HighExp="LBGstat, C30, HPh, Oxctl, dia15, Paraq, T0.30H, C90, LBGtran, LPh" /AntisenseName="ctaO" /AntisenseCor="-0.43946575370083102" /AntisenseRegPval="-13.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S444" upshifts 1200209 /Source="Nicolas_upshifts" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1200701..1201690) /gene="ctaO" /locus_tag="BSU_12080" /old_locus_tag="BSU12080" /EC_number="2.5.1.-" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10675592, 15491161, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10675592, 15491161, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor protoheme IX farnesyltransferase 1 (heme Osynthase)" /protein_id="NP_389090.2" /db_xref="EnsemblGenomes-Gn:BSU12080" /db_xref="EnsemblGenomes-Tr:CAB13065" /db_xref="GOA:O31652" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR006369" /db_xref="InterPro:IPR030470" /db_xref="SubtiList:BG13183" /db_xref="UniProtKB/Swiss-Prot:O31652" /translation="MQFWGRRLFLENTRDSAAISETKYIKASNRVTIYDFIKLAKPGI IISNSIAAFGGFWIAFASAEKTLTGLAFLMTMVTAMLGTAFVMASGTVYNNYFDRHMD AKMARTRSRASVTGKMPPAMILTYGSVLGIAGLAMLYSLNPLTAFLGLAAFIFYAIIY TVWVKRTSVWSTFVGSFPGAAPPLMGYCAVTGDFSMTAVLLYTIMFLWQPPHFWAIGI RRKEEYRAAGVPLLPVVKGNHVTKIKMMQYIAVLVPVTLLFPFSLGTGHISPFYFLAA LVLGGIWIKKSIKGFKTDDDVKWAKDMFVYSLIYFCLLFFIMMIDSFMMFLIR*" /label="ctaO CDS" gene complement(1200701..1201690) /gene="ctaO" /locus_tag="BSU_12080" /old_locus_tag="BSU12080" /label="ctaO gene" promotor_-10 complement(1201691..1201710) /Source="Nicolas_upshift_promotors" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="promotor_-10" upshifts complement(1201694) /Source="Nicolas_upshifts" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="upshifts" promotor_-35 complement(1201724..1201729) /Source="Nicolas_upshift_promotors" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="promotor_-35" CDS complement(1201813..1202061) /gene="cotT" /locus_tag="BSU_12090" /old_locus_tag="BSU12090" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1391045, 1917883, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1391045, 1917883, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (inner coat)" /protein_id="NP_389091.2" /db_xref="EnsemblGenomes-Gn:BSU12090" /db_xref="EnsemblGenomes-Tr:CAB13066" /db_xref="GOA:P11863" /db_xref="SubtiList:BG10495" /db_xref="UniProtKB/Swiss-Prot:P11863" /translation="MDYPLNEQSFEQITPYDERQPYYYPRPRPPFYPPYYYPRPYYPF YPFYPRPPYYYPRPRPPYYPWYGYGGGYGGGYGGGYGY*" /label="cotT CDS" gene complement(1201813..1202061) /gene="cotT" /locus_tag="BSU_12090" /old_locus_tag="BSU12090" /label="cotT gene" downshifts complement(1201823) /Source="Nicolas_upshifts" /id="D668" /incds=0 /nref=37 /ntot=82 /MaxReadThrough="5.73194" /MaxDrop="6.23577" /score="25.0951218" /energy="-8.4" /TU="U989" /idTUdmin="U990" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 1202057..1202061 /Source="Nicolas_upshift_promotors" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1202070..1202084 /Source="Nicolas_upshift_promotors" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1202079 /Source="Nicolas_upshifts" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1202086..1202105) /Source="Nicolas_upshift_promotors" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1202095) /Source="Nicolas_upshifts" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1202119..1202128) /Source="Nicolas_upshift_promotors" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1202176..1202183 /Source="Nicolas_upshift_promotors" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1202190..1202209) /Source="Nicolas_upshift_promotors" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1202197..1202216 /Source="Nicolas_upshift_promotors" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1202199) /Source="Nicolas_upshifts" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="upshifts" upshifts 1202210 /Source="Nicolas_upshifts" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1202211..1202314 /Source="Nicolas_S_feature" /locus_tag="new_1281024_1281127" /HighExp="Heat, T0.30H, T1.0H, ferm, Diami, dia5, T1.30H, M9-stat, T3.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S445" promotor_-35 complement(1202223..1202230) /Source="Nicolas_upshift_promotors" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1202315..1203718 /gene="pdaC" /locus_tag="BSU_12100" /old_locus_tag="BSU12100" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 17878218, 22277649" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 17878218, 22277649; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramic acid deacetylase" /protein_id="NP_389092.1" /db_xref="EnsemblGenomes-Gn:BSU12100" /db_xref="EnsemblGenomes-Tr:CAB13067" /db_xref="GOA:O34798" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR017219" /db_xref="InterPro:IPR021729" /db_xref="InterPro:IPR025303" /db_xref="InterPro:IPR037126" /db_xref="SubtiList:BG13184" /db_xref="UniProtKB/Swiss-Prot:O34798" /translation="MLAKRIKWFHVLIAVVCVVGLIGFFHNHSLKKETVMNKVRTDSQ YGNVEIATLVNDGKTFNYAVNYPVFKNEKMDSALKRFAEKEVRQFQKETKDVDQEHTT KRNELNVDYKIVHYAKQTVAIVFNEYKYIGGAHGQTVKKTFNYDFSKQAFLSIDDIFK EDADYLHKLSLIAYHELKKNKDIAADDALLKEGTAPKKENFSRFAIKEDYIELYFDTY QVAAGYLGEQSIAIKKSLLKDILKEQYIDKAKNKNKIKEQKPKHEVISLPKEETVDPN QKVIALTFDDGPNPATTNQILDSLKKYKGHATFFVLGSRVQYYPETLIRMLKEGNEVG NHSWSHPLLTRLSVKEALKQINDTQDIIEKISGYRPTLVRPPYGGINDELRSQMKMDV ALWDVDPEDWKDRNKKTIVDRVMNQAGDGRTILIHDIYRTSADAADEIIKKLTDQGYQ LVTVSQLEEVKKQREAK*" /label="pdaC CDS" gene 1202315..1203718 /gene="pdaC" /locus_tag="BSU_12100" /old_locus_tag="BSU12100" /label="pdaC gene" downshifts 1203707 /Source="Nicolas_upshifts" /id="D669" /incds=0 /nref=173 /ntot=238 /MaxReadThrough="1.38483" /MaxDrop="6.60322" /score="39.935002" /energy="-13.8" /TU="NA" /idTUdmin="U991" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1203758..1204231) /gene="yjfA" /locus_tag="BSU_12110" /old_locus_tag="BSU12110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389093.1" /db_xref="EnsemblGenomes-Gn:BSU12110" /db_xref="EnsemblGenomes-Tr:CAB13068" /db_xref="InterPro:IPR021224" /db_xref="SubtiList:BG13185" /db_xref="UniProtKB/Swiss-Prot:O34554" /translation="MKRLFMKASLVLFAVVFVFAVKGAPAKAETHAYDGKSPYYNDCA SSGSTKKSSNLVNASNQVIGVVELKFSSTCKTAWAKITMNNTLTSGYEANAEITRNTD GKRYNCDSAGGNGKAVAGQKSCYTPMVYDLDPRTSYAFGKYSGPNLNVWATTGSY*" /label="yjfA CDS" gene complement(1203758..1204231) /gene="yjfA" /locus_tag="BSU_12110" /old_locus_tag="BSU12110" /label="yjfA gene" downshifts complement(1203762) /Source="Nicolas_upshifts" /id="D670" /incds=0 /nref=33 /ntot=176 /MaxReadThrough="2.25434" /MaxDrop="5.38548" /score="20.5383759" /energy="-13.8" /TU="NA" /idTUdmin="U992" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1204253..1204271) /Source="Nicolas_upshift_promotors" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1204271) /Source="Nicolas_upshifts" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1204286..1204291) /Source="Nicolas_upshift_promotors" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1204356..1204523) /gene="yjfB" /locus_tag="BSU_12120" /old_locus_tag="BSU12120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389094.1" /db_xref="EnsemblGenomes-Gn:BSU12120" /db_xref="EnsemblGenomes-Tr:CAB13069" /db_xref="InterPro:IPR025906" /db_xref="SubtiList:BG13186" /db_xref="UniProtKB/Swiss-Prot:O34438" /translation="MDIPALSVAMHQASLAQNVNIALTKKRLDTAQQNADQTLKMIQH PTLGQTIDVKA*" /label="yjfB CDS" gene complement(1204356..1204523) /gene="yjfB" /locus_tag="BSU_12120" /old_locus_tag="BSU12120" /label="yjfB gene" downshifts complement(1204359) /Source="Nicolas_upshifts" /id="D671" /incds=0 /nref=109 /ntot=232 /MaxReadThrough="3.53249" /MaxDrop="4.93218" /score="-9.08395816" /energy="-13.9" /TU="U993" /idTUdmin="U993" /TUdmin="-576" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1204535..1204553) /Source="Nicolas_upshift_promotors" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1204544) /Source="Nicolas_upshifts" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1204566..1204573) /Source="Nicolas_upshift_promotors" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1204650..1205549 /gene="yjfC" /locus_tag="BSU_12130" /old_locus_tag="BSU12130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389095.2" /db_xref="EnsemblGenomes-Gn:BSU12130" /db_xref="EnsemblGenomes-Tr:CAB13070" /db_xref="InterPro:IPR018728" /db_xref="SubtiList:BG13187" /db_xref="UniProtKB/Swiss-Prot:O34458" /translation="MNLVMEKTFEQYEKLFSMEEQKREDVFRYTMMRPFEKMWTAIQV PLKAKEPNGYDVIMAAKMLGYLDVRDAESGQKALQILKESHVSETAESALRQCIFFAE REQLRVNAKEIKFGLYIADPNKLQLQKGYCGFGGIPGFIHVWINPNSYNLPRIPSIIA HEFHHNVRFSYIDFHHGSVSVGDYLVIEGLAESFARELFGTERLGPWVTRFDHEDLQY SIDVINEVLDVKGFSEVSRYMFGDPIANDQGFKPAGLSAFAGYAVGYHAVQSFMNQHH ITISEATRLDAKTIISQCGLFST*" /label="yjfC CDS" gene 1204650..1205549 /gene="yjfC" /locus_tag="BSU_12130" /old_locus_tag="BSU12130" /label="yjfC gene" CDS complement(1205558..1205956) /gene="yjgA" /locus_tag="BSU_12140" /old_locus_tag="BSU12140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_389096.1" /db_xref="EnsemblGenomes-Gn:BSU12140" /db_xref="EnsemblGenomes-Tr:CAB13071" /db_xref="GOA:O35027" /db_xref="InterPro:IPR021257" /db_xref="SubtiList:BG13188" /db_xref="UniProtKB/Swiss-Prot:O35027" /translation="MKRNRWIYAVFTILIIGLGLGSRAFSSVLPDTLNTYLGDSLWAA MIFTGCGFLFRKLKTMITGIISLSFCFVIEFSQLYHAEWIDQIRDTSLGGLVLGYGFL WSDIEAYTIGIAACAAIELLVLGIKKRRCM*" /label="yjgA CDS" gene complement(1205558..1205956) /gene="yjgA" /locus_tag="BSU_12140" /old_locus_tag="BSU12140" /label="yjgA gene" downshifts complement(1205588) /Source="Nicolas_upshifts" /id="D672" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="2.86089" /MaxDrop="2.52307" /score="23.8106216" /energy="-10.1" /TU="U994,U995" /idTUdmin="U995" /TUdmin="-243" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1205985..1206004) /Source="Nicolas_upshift_promotors" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1206004) /Source="Nicolas_upshifts" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1206019..1206026) /Source="Nicolas_upshift_promotors" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1206057..1206632) /gene="yjgB" /locus_tag="BSU_12150" /old_locus_tag="BSU12150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1580552" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389097.1" /db_xref="EnsemblGenomes-Gn:BSU12150" /db_xref="EnsemblGenomes-Tr:CAB13072" /db_xref="InterPro:IPR025453" /db_xref="PDB:4YGT" /db_xref="SubtiList:BG13189" /db_xref="UniProtKB/Swiss-Prot:O34960" /translation="MKKTMSAITAAAAVTSCFTGFGAASFSAPAKAAAQTNTLSENTN QSAAELVKNLYNTAYKGEMPQQAQGLTINKSTKGDVHAAFGEPERPVGGDNRFDLYHW NMGQPGYGFSYHKDMTISEIRYFGTGVERQLNLGGVTPEVLQKQLGPVNRVLTVPFTD EIDYVYDTGRYELHFVIGTDQTADHVNLKAK*" /label="yjgB CDS" gene complement(1206057..1206632) /gene="yjgB" /locus_tag="BSU_12150" /old_locus_tag="BSU12150" /label="yjgB gene" downshifts complement(1206072) /Source="Nicolas_upshifts" /id="D673" /incds=0 /nref=3 /ntot=16 /MaxReadThrough="5.38565" /MaxDrop="3.9021" /score="23.8106216" /energy="-10.1" /TU="U995" /idTUdmin="U995" /TUdmin="-727" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1206651..1206669) /Source="Nicolas_upshift_promotors" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1206666) /Source="Nicolas_upshifts" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1206683..1206689) /Source="Nicolas_upshift_promotors" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1206707..1206713 /Source="Nicolas_upshift_promotors" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1206728..1206746 /Source="Nicolas_upshift_promotors" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1206729 /Source="Nicolas_upshifts" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="upshifts" CDS 1206778..1209735 /gene="yjgC" /locus_tag="BSU_12160" /old_locus_tag="BSU12160" /EC_number="1.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdoenzyme; putative formate dehydrogenase" /protein_id="NP_389098.1" /db_xref="EnsemblGenomes-Gn:BSU12160" /db_xref="EnsemblGenomes-Tr:CAB13073" /db_xref="GOA:O34720" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR006478" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR019574" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG13190" /db_xref="UniProtKB/Swiss-Prot:O34720" /translation="MAGKKTITINGVEMEASEEQTVLQLLNNSSIEVPQVCYHPSLGP IETCDTCIVSINGELKRSCSAELKDGDVIDTLSPDVKKAQVIGMDKILYNHELYCTVC DYNNGGCEIHNTVKEMKINHQSIPFDHKPYHKDESHPFYRYDPDQCILCGRCVEACQD VQVTETLTIDWERKRPRVIWDNDVPINESSCVSCGHCSTVCPCNAMMEKGMEGEAGYL TGINNETLRPMIEITKGVETGYGSILAISDMESAMRDERIKKTKTVCTYCGVGCSFDV WTKGRDILKVEPQEEAPANGISTCVKGKFGWDFVNSEERLTKPLIREGDHFREAEWEE ALLLIASKFTELKEAFGPDSLAFITSSKCTNEESYLMQKLARGVIGTNNVDNCSRYCQ SPATAGLFRTVGYGGDSGSITDIAQADLVLIIGSNTSESHPVLSTRIKRAHKLRGQKV IVADIRKHEMAERSDLFVQPRAGSDIVWLNAIAKYLIENGKADERFLRERVNGRDEYV KSLAPYTLEYAEEKTGIDQETLIQMAEMIGQADSVCALWAMGVTQHIGGSDTSTAISN LLLVTGNYGKPGAGSYPLRGHNNVQGASDFGSMPDRLPGYEKVTDEQVRQKYERVWGV PLPKEPGMTNHEMIEKIHSGQLKAMYVKGEEMGLVDSNINHVHAAYEKLDFFVVQDIF LSRTAEFADVVLPASPSLEKEGTFTNTERRIQRLYQVFEPLGESKPDWQIIMEVANKL GAGWLYEHPADIMEEAAKLSPIYAGVTYERLEGYNSLQWPVNADGKDSPLLFTERFPF PDGKAILYPVQWTEPKEFGEEYDIHVNNGRLLEHFHEGNLTYKSKGISEKTPEVFLEI SPELAAERGIQDGTLVRLTSPFGNVKVKCLITDRVKGKEVYLPMNDSGEAAINLLTGS HADKDTDTPAYKETSAKMEILKHDGISPLPKINHRNGNPQPQIGVQVHKKWARKDYIF PGDAVKRGMGHNG*" /label="yjgC CDS" gene 1206778..1209735 /gene="yjgC" /locus_tag="BSU_12160" /old_locus_tag="BSU12160" /label="yjgC gene" CDS 1209728..1210288 /gene="yjgD" /locus_tag="BSU_12170" /old_locus_tag="BSU12170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389099.1" /db_xref="EnsemblGenomes-Gn:BSU12170" /db_xref="EnsemblGenomes-Tr:CAB13074" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG13191" /db_xref="UniProtKB/Swiss-Prot:O34681" /translation="MAKAIKRIQKIEVTEEDQRKRDLREIEDALIDHKEAILETLHML GHMNERGVLPLLRGLFGQGDKVLDILVKKADTEETANTLKNLLLLFGTLGMLDVKQLE PLILKVNAGVASAVEQKNSEEKTGYFDIIRSLKDPEINKSITLLFSFLKGMGQDTKEL ERTTQPPEHQKHHQEPREKRGMNKRD*" /label="yjgD CDS" gene 1209728..1210288 /gene="yjgD" /locus_tag="BSU_12170" /old_locus_tag="BSU12170" /label="yjgD gene" downshifts 1210281 /Source="Nicolas_upshifts" /id="D674" /incds=0 /nref=18 /ntot=84 /MaxReadThrough="5.25706" /MaxDrop="6.46184" /score="20.7921843" /energy="-15" /TU="U996" /idTUdmin="U996" /TUdmin="-819" /isTUend="FALSE" /label="downshifts" S_feature 1210326..1210444 /Source="Nicolas_S_feature" /locus_tag="new_1289139_1289257" /HighExp="Etha, Salt, Heat, S8, M9-stat, S7, LPhT, G135, C30, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S446" promotor_-35 1210422..1210425 /Source="Nicolas_upshift_promotors" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1210441..1210460 /Source="Nicolas_upshift_promotors" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1210446 /Source="Nicolas_upshifts" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="upshifts" CDS 1210485..1211126 /gene="yjhA" /locus_tag="BSU_12180" /old_locus_tag="BSU12180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389100.1" /db_xref="EnsemblGenomes-Gn:BSU12180" /db_xref="EnsemblGenomes-Tr:CAB13075" /db_xref="GOA:O34725" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="PDB:3CFU" /db_xref="SubtiList:BG13192" /db_xref="UniProtKB/Swiss-Prot:O34725" /translation="MKKVLLLLFVLTIGLALSACSQSSDASEKEKPKEKKSQEELEKE LDKELKKGGEPKTKKDDQIHKIGETFKAGHTNFTVNKVDRVQKGEYMNVGGAVNEETK TIKDDEERLIIEVTMENIGEDSISYNFIGFDLRDKNDQSVRPVFSIEEKGRILMGGTL VSGKKVTGVLSYVIPKGEQKHYTLVYNPFLADTNSSNTEERVKDDIDYLVKLD*" /label="yjhA CDS" gene 1210485..1211126 /gene="yjhA" /locus_tag="BSU_12180" /old_locus_tag="BSU12180" /label="yjhA gene" downshifts complement(1210494) /Source="Nicolas_upshifts" /id="D675" /incds=0 /nref=7 /ntot=57 /MaxReadThrough="2.5769" /MaxDrop="3.81596" /score="-9.34186213" /energy="-3" /TU="NA" /idTUdmin="U998" /TUdmin=1386 /isTUend="FALSE" /label="downshifts" downshifts 1211099 /Source="Nicolas_upshifts" /id="D676" /incds=0 /nref=24 /ntot=186 /MaxReadThrough="4.29897" /MaxDrop="3.4683" /score="19.6571267" /energy="-17" /TU="U997" /idTUdmin="U996" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS 1211205..1211831 /gene="yjhB" /locus_tag="BSU_12190" /old_locus_tag="BSU12190" /EC_number="3.6.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12483591, 16513759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ADP-ribose pyrophosphatase" /protein_id="NP_389101.2" /db_xref="EnsemblGenomes-Gn:BSU12190" /db_xref="EnsemblGenomes-Tr:CAB13076" /db_xref="GOA:C0SPC3" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="SubtiList:BG13193" /db_xref="UniProtKB/Swiss-Prot:C0SPC3" /translation="MIKVQTKWLERAQRIRAIAQAGLAFSKDVYDRERYEELMKLSAE MMADYSEKDIEVITDLWQGEKGYPTPKADVRGAVFRENQILLVREKHDELWSLPGGFC EIGLSPAENVVKEIKEESGYDTEPSRLLAVLDSHKHSHPPQPYHYYKIFIACSMTDGQ GETGIETNHAAFFPEDRLPPLSPKRNTPSQLSMLFDFLRHPDKKTIFD*" /label="yjhB CDS" gene 1211205..1211831 /gene="yjhB" /locus_tag="BSU_12190" /old_locus_tag="BSU12190" /label="yjhB gene" downshifts 1211833 /Source="Nicolas_upshifts" /id="D677" /incds=0 /nref=97 /ntot=202 /MaxReadThrough="0.597580000000001" /MaxDrop="6.62023" /score="12.2319602" /energy="-7" /TU="NA" /idTUdmin="U997" /TUdmin=7 /isTUend="TRUE" /label="downshifts" downshifts complement(1211836) /Source="Nicolas_upshifts" /id="D678" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.18907" /MaxDrop="3.31161" /score="10.5815896" /energy="-7" /TU="NA" /idTUdmin="U998" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(1211862..1212140) /gene="yjiA" /locus_tag="BSU_12200" /old_locus_tag="BSU12200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 14563871" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389102.1" /db_xref="EnsemblGenomes-Gn:BSU12200" /db_xref="EnsemblGenomes-Tr:CAB13077" /db_xref="SubtiList:BG13194" /db_xref="UniProtKB/Swiss-Prot:O34679" /translation="MAAQTDYKKQVVGILLSLAFVLFVFSFSERHEKPLVEGKKQENW HTVVDKASVKIYGSRLVEENKLKQKLGHKQADSILTLLKLANEKHITL*" /label="yjiA CDS" gene complement(1211862..1212140) /gene="yjiA" /locus_tag="BSU_12200" /old_locus_tag="BSU12200" /label="yjiA gene" downshifts complement(1211880) /Source="Nicolas_upshifts" /id="D679" /incds=0 /nref=162 /ntot=247 /MaxReadThrough="1.96302" /MaxDrop="5.98058" /score="10.5815896" /energy="-7" /TU="NA" /idTUdmin="U998" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1212169..1212180) /Source="Nicolas_upshift_promotors" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1212182..1212188) /Source="Nicolas_upshift_promotors" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1212188) /Source="Nicolas_upshifts" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1212190..1212606) /Source="Nicolas_S_feature" /locus_tag="new_1291003_1291419_c" /HighExp="S6, S7, S8, S5, BT, C30, Pyr, G/S, C90, B36" /AntisenseName="yjiB" /AntisenseCor="-0.25565388711625397" /AntisenseRegPval="-4.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S447" upshifts 1212358 /Source="Nicolas_upshifts" /id="U999" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig=1 /xcortree=3183 /SigmaFactorBS="tatgcctaaggtcacgttgtgagccaaaacagcagtgcagaa tagaaaaaaattgaaagatTATGGTAAGATGAACGAAATtcgagggggaatatatgat g" /listShort="S448, yjiB, yjiC" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1212359..1212378 /Source="Nicolas_upshift_promotors" /id="U999" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig=1 /xcortree=3183 /SigmaFactorBS="tatgcctaaggtcacgttgtgagccaaaacagcagtgcagaa tagaaaaaaattgaaagatTATGGTAAGATGAACGAAATtcgagggggaatatatgat g" /listShort="S448, yjiB, yjiC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1212376..1212530 /Source="Nicolas_S_feature" /locus_tag="new_1291189_1291343" /HighExp="BC, T5.0H, T4.0H, C90, Sw, T3.30H, Lbstat, Diami, dia5, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.995811" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S448" CDS 1212531..1213721 /gene="cypE" /locus_tag="BSU_12210" /old_locus_tag="BSU12210" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:25587700" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25587700; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 CYP109B1, monooxygenase" /protein_id="NP_389103.1" /db_xref="EnsemblGenomes-Gn:BSU12210" /db_xref="EnsemblGenomes-Tr:CAB13078" /db_xref="GOA:O34374" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="PDB:4RM4" /db_xref="SubtiList:BG13195" /db_xref="UniProtKB/Swiss-Prot:O34374" /translation="MNVLNRRQALQRALLNGKNKQDAYHPFPWYESMRKDAPVSFDEE NQVWSVFLYDDVKKVVGDKELFSSCMPQQTSSIGNSIINMDPPKHTKIRSVVNKAFTP RVMKQWEPRIQEITDELIQKFQGRSEFDLVHDFSYPLPVIVISELLGVPSAHMEQFKA WSDLLVSTPKDKSEEAEKAFLEERDKCEEELAAFFAGIIEEKRNKPEQDIISILVEAE ETGEKLSGEELIPFCTLLLVAGNETTTNLISNAMYSILETPGVYEELRSHPELMPQAV EEALRFRAPAPVLRRIAKRDTEIGGHLIKEGDMVLAFVASANRDEAKFDRPHMFDIRR HPNPHIAFGHGIHFCLGAPLARLEANIALTSLISAFPHMECVSITPIENSVIYGLKSF RVKM*" /label="cypE CDS" gene 1212531..1213721 /gene="cypE" /locus_tag="BSU_12210" /old_locus_tag="BSU12210" /label="cypE gene" promotor_-10 complement(1212604..1212623) /Source="Nicolas_upshift_promotors" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1212606) /Source="Nicolas_upshifts" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1212637..1212646) /Source="Nicolas_upshift_promotors" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1213744..1214922 /gene="ppuG" /locus_tag="BSU_12220" /old_locus_tag="BSU12220" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 24893262, 27444326; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polyphenols TDP-rhamnosyltransferase, promiscuous" /protein_id="NP_389104.1" /db_xref="EnsemblGenomes-Gn:BSU12220" /db_xref="EnsemblGenomes-Tr:CAB13079" /db_xref="GOA:O34539" /db_xref="InterPro:IPR002213" /db_xref="InterPro:IPR006326" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG13196" /db_xref="UniProtKB/Swiss-Prot:O34539" /translation="MKKYHISMINIPAYGHVNPTLALVEKLCEKGHRVTYATTEEFAP AVQQAGGEALIYHTSLNIDPKQIREMMEKNDAPLSLLKESLSILPQLEELYKDDQPDL IIYDFVALAGKLFAEKLNVPVIKLCSSYAQNESFQLGNEDMLKKIREAEAEFKAYLEQ EKLPAVSFEQLAVPEALNIVFMPKSFQIQHETFDDRFCFVGPSLGERKEKESLLIDKD DRPLMLISLGTAFNAWPEFYKMCIKAFRDSSWQVIMSVGKTIDPESLEDIPANFTIRQ SVPQLEVLEKADLFISHGGMNSTMEAMNAGVPLVVIPQMYEQELTANRVDELGLGVYL PKEEVTVSSLQEAVQAVSSDQELLSRVKNMQKDVKEAGGAERAAAEIEAFMKKSAVPQ *" /label="ppuG CDS" gene 1213744..1214922 /gene="ppuG" /locus_tag="BSU_12220" /old_locus_tag="BSU12220" /label="ppuG gene" CDS complement(1214963..1215151) /gene="yjzI" /locus_tag="BSU_12229" /old_locus_tag="BSU12229" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="YP_003097710.1" /db_xref="EnsemblGenomes-Gn:BSU12229" /db_xref="EnsemblGenomes-Tr:CAX52600" /db_xref="UniProtKB/Swiss-Prot:C0H3Z3" /translation="METKKEEYETKGYDTSIVYEFNEYPDARSGRCDNCDYTLFKSSV KGGKFLRECRRCGMKKNI*" /label="yjzI CDS" gene complement(1214963..1215151) /gene="yjzI" /locus_tag="BSU_12229" /old_locus_tag="BSU12229" /label="yjzI gene" downshifts complement(1214979) /Source="Nicolas_upshifts" /id="D680" /incds=0 /nref=94 /ntot=231 /MaxReadThrough="-0.1433" /MaxDrop="5.1712" /score="13.0160925" /energy="-9.5" /TU="NA" /idTUdmin="U1001" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1215177..1215196) /Source="Nicolas_upshift_promotors" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1215180) /Source="Nicolas_upshifts" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1215210..1215216) /Source="Nicolas_upshift_promotors" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1215238..1215245 /Source="Nicolas_upshift_promotors" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1215260..1215279 /Source="Nicolas_upshift_promotors" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1215271 /Source="Nicolas_upshifts" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1215286..1215305) /Source="Nicolas_upshift_promotors" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1215290) /Source="Nicolas_upshifts" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1215320..1215327) /Source="Nicolas_upshift_promotors" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1215325..1216137 /gene="yjjA" /locus_tag="BSU_12230" /old_locus_tag="BSU12230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389105.1" /db_xref="EnsemblGenomes-Gn:BSU12230" /db_xref="EnsemblGenomes-Tr:CAB13080" /db_xref="GOA:O34394" /db_xref="InterPro:IPR003754" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG13197" /db_xref="UniProtKB/Swiss-Prot:O34394" /translation="MGKGLLGKRVAIGGSRKTEEISTIIEKQGGIPVIRPLQGTVYLA EKQVEPDLRTFAEEKADWVIFTTGIGLETLVDMAEKIGLKDEFLQAIRQAKAACRGYK TLSALKKLGITPEASDEDGTTRGLIRSLEPHDFSGKTVMVQLHGEKAPALMAFLEEKG ASVLPILPYQHIPPEEETVERLCRELMNDEVDAVCFTTAIQVRSLFDFAKGRGYINEV KKVFEERAIAAAVGKVTAEALREEGITRLLAPEIERMGAMIVELAKYYEEKE*" /label="yjjA CDS" gene 1215325..1216137 /gene="yjjA" /locus_tag="BSU_12230" /old_locus_tag="BSU12230" /label="yjjA gene" downshifts 1216116 /Source="Nicolas_upshifts" /id="D681" /incds=0 /nref=196 /ntot=254 /MaxReadThrough="3.61369" /MaxDrop="5.73094" /score="10.6328997" /energy="-14.5" /TU="U1002" /idTUdmin="U1002" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1216183..1216935) /gene="yjkA" /locus_tag="BSU_12240" /old_locus_tag="BSU12240" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_389106.1" /db_xref="EnsemblGenomes-Gn:BSU12240" /db_xref="EnsemblGenomes-Tr:CAB13081" /db_xref="GOA:O34684" /db_xref="InterPro:IPR005226" /db_xref="SubtiList:BG13198" /db_xref="UniProtKB/Swiss-Prot:O34684" /translation="MDYLSLSLTMIFVLIALFLSKSFKAGVEKDMIIATIRAAVQLLI IGYVLSLIFRGDHPVFILLMVLLMLAVAAQNVIKRKKNTIGSFWRVFAALAIVEIVTQ GILLSLHIIPLTARYVIPISGMVIGNSMVLSSLFLNRLNSEVGVRKEEIQLILSLGGT PKQSIQRILTSAMKMSMIPTLESQKTLGLVQLPGMMTGQILAGADPIQAVRFQLLIVF TTMASAALTCVILSVLTYPSLFTVHQQLKQNE*" /label="yjkA CDS" gene complement(1216183..1216935) /gene="yjkA" /locus_tag="BSU_12240" /old_locus_tag="BSU12240" /label="yjkA gene" downshifts complement(1216192) /Source="Nicolas_upshifts" /id="D682" /incds=0 /nref=5 /ntot=153 /MaxReadThrough="0.924970000000001" /MaxDrop="3.5673" /score="13.1058081" /energy="-12.8" /TU="NA" /idTUdmin="U1001" /TUdmin="-1210" /isTUend="FALSE" /label="downshifts" CDS complement(1216935..1217687) /gene="yjkB" /locus_tag="BSU_12250" /old_locus_tag="BSU12250" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389107.1" /db_xref="EnsemblGenomes-Gn:BSU12250" /db_xref="EnsemblGenomes-Tr:CAB13082" /db_xref="GOA:O34756" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13199" /db_xref="UniProtKB/Swiss-Prot:O34756" /translation="MEANDQTQNIPAISFRSVRKSYKQDGQTYDVLQDVTGDIQQGAI VAVLGPSGSGKSTLLSMCNLMRTPDSGEVNIYGKEVREWNVNELRRTAALAFQSAPVL DGTVRDNLSLVQRLHQSQLYSPEKLASLAGLPPELLDRSARDLSGGQRQRLSLARTLS NPSSILLLDEITSALDPVSALEIEELIKRQHQEKKWTVMWVTHNMEQAKRIADTIWFM ADGRLLEIAETDTFFSAPQHEAAKEFLKGGTR*" /label="yjkB CDS" gene complement(1216935..1217687) /gene="yjkB" /locus_tag="BSU_12250" /old_locus_tag="BSU12250" /label="yjkB gene" CDS complement(1217807..1218781) /gene="yjlA" /locus_tag="BSU_12260" /old_locus_tag="BSU12260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14627822, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_389108.1" /db_xref="EnsemblGenomes-Gn:BSU12260" /db_xref="EnsemblGenomes-Tr:CAB13083" /db_xref="GOA:O34428" /db_xref="InterPro:IPR032713" /db_xref="SubtiList:BG13200" /db_xref="UniProtKB/Swiss-Prot:O34428" /translation="MKAIVIGILASLFFAVTFILNRAMELSGGSWLWSSSLRFIFMVP FLCLIVIMRGTFTPLLLEMRKKPFYWIKWSFVGFVLFYAPITFAAAYGPGWLIAGTWQ ITIVAGVLLSPLFYVKQDMPGGPQLIRQKIPLVSLGTSVIILIGAALIQLQHAESLSG RMLLFSVLPVVIAAFAYPLGNRRMLEEYGGRLDTFQRVLGMTLASLPFWLILAAYGWW SDGLPTASQTVQSFIVAVSSGIIATVLFFWATDMVRDNPQKLAAVEATQSGEVIFALL GEIVLLSGVFPSLLSFAGLFIIIAGMMLHTFASQPRKPKKKAQSNLTA*" /label="yjlA CDS" gene complement(1217807..1218781) /gene="yjlA" /locus_tag="BSU_12260" /old_locus_tag="BSU12260" /label="yjlA gene" downshifts complement(1217842) /Source="Nicolas_upshifts" /id="D683" /incds=0 /nref=1 /ntot=95 /MaxReadThrough="1.84381" /MaxDrop="2.54799" /score="4.80318278" /energy="-14.5" /TU="NA" /idTUdmin="U1004" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1218802..1218821) /Source="Nicolas_upshift_promotors" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1218828) /Source="Nicolas_upshifts" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1218830..1221336) /Source="Nicolas_S_feature" /locus_tag="new_1297643_1300149_c" /HighExp="Lbstat, S2, M0t90, nit, BT, M40t90, ferm, BC, C30, Gly" /AntisenseName="ndh" /AntisenseCor="-0.74506751931257098" /AntisenseRegPval="-48.1" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S449" promotor_-35 complement(1218836..1218843) /Source="Nicolas_upshift_promotors" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1218864..1218870 /Source="Nicolas_upshift_promotors" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1218885..1218903 /Source="Nicolas_upshift_promotors" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1218888 /Source="Nicolas_upshifts" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="upshifts" CDS 1218913..1219410 /gene="yjlB" /locus_tag="BSU_12270" /old_locus_tag="BSU12270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10704478" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; cupin family" /protein_id="NP_389109.1" /db_xref="EnsemblGenomes-Gn:BSU12270" /db_xref="EnsemblGenomes-Tr:CAB13084" /db_xref="GOA:O34612" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014500" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG13201" /db_xref="UniProtKB/Swiss-Prot:O34612" /translation="MERETQTYFFPDDGRIPNHPDFPLVVYQNALKDTGLAERIVTRH GWSNSWSGSVFPYHHYHSNTHEVLIALRREAVIQFGGEKGAAIPFKSGDAVVIPAGVG HKKLSSSPDFTVLGAYPGGVQYDMKTGKPNEREEAVKQIKQAALPANDPITGKREPLL EIWVK*" /label="yjlB CDS" gene 1218913..1219410 /gene="yjlB" /locus_tag="BSU_12270" /old_locus_tag="BSU12270" /label="yjlB gene" S_feature 1219411..1219524 /Source="Nicolas_S_feature" /locus_tag="new_1298224_1298337" /HighExp="Etha, M9-stat, B60, Salt, Gly, LPhT, Heat, Sw, HiTm, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S450" promotor_-35 1219504..1219508 /Source="Nicolas_upshift_promotors" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1219524..1219543 /Source="Nicolas_upshift_promotors" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1219526..1219798 /Source="Nicolas_S_feature" /locus_tag="new_1298339_1298611" /HighExp="LBGtran, dia5, Lbexp, LBGexp, dia0, HPh, aero, LPh, BMM, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S451" upshifts 1219526 /Source="Nicolas_upshifts" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="upshifts" CDS 1219799..1220221 /gene="yjlC" /locus_tag="BSU_12280" /old_locus_tag="BSU12280" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16513748, 17015645, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389110.1" /db_xref="EnsemblGenomes-Gn:BSU12280" /db_xref="EnsemblGenomes-Tr:CAB13085" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG13202" /db_xref="UniProtKB/Swiss-Prot:O34633" /translation="MPETIDQTNASVSQSQQDLIDQLLKPEVQESLTVLVDQLPKLTE LVNILTKSYDFAQSVATDEVLKSDTVGAITEILEPVKETAKEVAATAIEAKDRAEASN ETIGLFGLLRMLKDPQAQKLFRFANSYLEVMNERENQK*" /label="yjlC CDS" gene 1219799..1220221 /gene="yjlC" /locus_tag="BSU_12280" /old_locus_tag="BSU12280" /label="yjlC gene" CDS 1220261..1221439 /gene="ndh" /locus_tag="BSU_12290" /old_locus_tag="BSU12290" /EC_number="1.6.99.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6816592, 16513748, 17015645, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6816592, 16513748, 17015645, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH dehydrogenase" /protein_id="NP_389111.1" /db_xref="EnsemblGenomes-Gn:BSU12290" /db_xref="EnsemblGenomes-Tr:CAB13086" /db_xref="GOA:P80861" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13203" /db_xref="UniProtKB/Swiss-Prot:P80861" /translation="MSKHIVILGAGYGGVLSALTVRKHYTKEQARVTVVNKYPTHQII TELHRLAAGNVSEKAVAMPLEKLFKGKDIDLKIAEVSSFSVDKKEVALADGSTLTYDA LVVGLGSVTAYFGIPGLEENSMVLKSAADANKVFQHVEDRVREYSKTKNEADATILIG GGGLTGVELVGELADIMPNLAKKYGVDHKEIKLKLVEAGPKILPVLPDDLIERATASL EKRGVEFLTGLPVTNVEGNVIDLKDGSKVVANTFVWTGGVQGNPLVGESGLEVNRGRA TVNDFLQSTSHEDVFVAGDSAVYFGPDGRPYPPTAQIAWQMGELIGYNLFAYLEGKTL ETFKPVNSGTLASLGRKDAVAIIGANSTPLKGLPASLMKEASNVRYLTHIKGLFSLAY *" /label="ndh CDS" gene 1220261..1221439 /gene="ndh" /locus_tag="BSU_12290" /old_locus_tag="BSU12290" /label="ndh gene" promotor_no_box 1221270..1221370 /Source="Nicolas_upshift_promotors" /id="U1007" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.015984015984016" /xcortree=1732 /SigmaFactorBS="tcaagccagtaaactctggtacacttgcaagccttggacgca aagacgcggttgccatcattggtgctaattctacaccgcttaaaggtcttcctgcttc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(1221328..1221346) /Source="Nicolas_upshift_promotors" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1221330 /Source="Nicolas_upshifts" /id="U1007" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.015984015984016" /xcortree=1732 /SigmaFactorBS="tcaagccagtaaactctggtacacttgcaagccttggacgca aagacgcggttgccatcattggtgctaattctacaccgcttaaaggtcttcctgcttc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1221336) /Source="Nicolas_upshifts" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1221358..1221366) /Source="Nicolas_upshift_promotors" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1221438 /Source="Nicolas_upshifts" /id="D684" /incds=0 /nref=220 /ntot=278 /MaxReadThrough="2.01042" /MaxDrop="8.69373" /score="30.6421047" /energy="-23.1" /TU="NA" /idTUdmin="U1005" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 1221547..1221554 /Source="Nicolas_upshift_promotors" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1221569..1221588 /Source="Nicolas_upshift_promotors" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1221594 /Source="Nicolas_upshifts" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="upshifts" CDS 1221637..1223058 /gene="uxaC" /locus_tag="BSU_12300" /old_locus_tag="BSU12300" /EC_number="5.3.1.12" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galacturonate isomerase" /protein_id="NP_389112.1" /db_xref="EnsemblGenomes-Gn:BSU12300" /db_xref="EnsemblGenomes-Tr:CAB13087" /db_xref="GOA:O34808" /db_xref="InterPro:IPR003766" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG13204" /db_xref="UniProtKB/Swiss-Prot:O34808" /translation="MEPFMGKNFLLKNETAVSLYHNYAKDMPIIDYHCHLSPKEIYEN KTFQNITEAWLYGDHYKWRIMRANGIEETYITGDAPDEEKFMAWAKTVPMAIGNPLYN WTHLELQRFFGIYEILNEKSGSAIWKQTNKLLKGEGFGARDLIVKSNVKVVCTTDDPV DSLEYHLLLKEDKDFPVSVLPGFRPDKGLEINREGFPEWVQALEDAAAISITTYDEFL KALEKRVRFFHSAGGRVSDHAIDTMVFAETTKEEAGRIFSDRLQGTEVSCEDEKKFKT YTLQFLCGLYAELDWAMQFHINALRNTNTKMMKRLGPDTGYDSMNDEEIAKPLYKLLN SVEMKNQLPKTILYSLNPNDNYVIASMINSFQDGITPGKIQFGTAWWFNDTKDGMLDQ MKALSNVGLFSRFIGMLTDSRSFLSYTRHEYFRRIVCNLIGEWVENGEVPRDMELLGS IVQGICYDNAKHYFQFQEEKANV*" /label="uxaC CDS" gene 1221637..1223058 /gene="uxaC" /locus_tag="BSU_12300" /old_locus_tag="BSU12300" /label="uxaC gene" CDS 1223126..1224505 /gene="exuM" /locus_tag="BSU_12310" /old_locus_tag="BSU12310" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9882655, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+:altronate/mannonate symporter" /protein_id="NP_389113.1" /db_xref="EnsemblGenomes-Gn:BSU12310" /db_xref="EnsemblGenomes-Tr:CAB13088" /db_xref="GOA:O34961" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13205" /db_xref="UniProtKB/Swiss-Prot:O34961" /translation="MRTELANKVVSVETEKRLSLKEKMSYGFGDFGNGFMFDLGQIYL LKYFTDVAGIPAAMAGGIFLVSKLFAAITDPIVGSSIDYRKNIGKRGKFRPYLLIGSI VLAVLTVLIFLSPNVSTTGKLIYAYASYMIWGIGYSFVNIPYGSLGAAMTQNSEDRTS ISTFRQIGSLGALFITSVAVMPLLVKFDNPKVGYPVVMGLFAALGVFWFYICYRNCKE RIIISEAPKEKLTLSSVVKTFITNKPLLTLVLMTIFSISAYNIKSAMLVYFAQYNLGN VELMAYMNFIIIGSSFLGVVFLPKLVKMFGKKRTAMIGFGISVAADLINFMLPSNVYV FTILASIAFIGISIPNGITWALVSDIIDYGEWKSGERKEATTYSLFNFSRKLAQSLSG FLSGIGLGIIGYVPNAVQTAQALIGIKALLLLYPAIALALAMFIIGFLYKLTDQQHAQ IVQDLHQKS*" /label="exuM CDS" gene 1223126..1224505 /gene="exuM" /locus_tag="BSU_12310" /old_locus_tag="BSU12310" /label="exuM gene" promotor_-10 complement(1223645..1223664) /Source="Nicolas_upshift_promotors" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1223650) /Source="Nicolas_upshifts" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1223678..1223685) /Source="Nicolas_upshift_promotors" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1224530 /Source="Nicolas_upshifts" /id="U1011" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.926073926073926" /psig="0.926073926073926" /xcortree=1048 /SigmaFactorBS="gctcagatcgttcaggatcttcatcaaaagagctgacaatat aatataaagaatatttaaaataatttgtAAATAAAAtgtgtttgtaggggtttcgctt g" /listShort="S452, yjmC, yjmD, uxuA, uxuB, exuT, exuR" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1224540..1224547 /Source="Nicolas_upshift_promotors" /id="U1011" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.926073926073926" /psig="0.926073926073926" /xcortree=1048 /SigmaFactorBS="gctcagatcgttcaggatcttcatcaaaagagctgacaatat aatataaagaatatttaaaataatttgtAAATAAAAtgtgtttgtaggggtttcgctt g" /listShort="S452, yjmC, yjmD, uxuA, uxuB, exuT, exuR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1224542..1224609 /Source="Nicolas_S_feature" /locus_tag="new_1303355_1303422" /HighExp="S4, S5, S6, S3, S8, S7, T5.0H, T4.0H, T3.30H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S452" CDS 1224610..1225623 /gene="yjmC" /locus_tag="BSU_12320" /old_locus_tag="BSU12320" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9579062, 9882655, 16788182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389114.1" /db_xref="EnsemblGenomes-Gn:BSU12320" /db_xref="EnsemblGenomes-Tr:CAB13089" /db_xref="GOA:O34736" /db_xref="InterPro:IPR003767" /db_xref="InterPro:IPR036111" /db_xref="SubtiList:BG13206" /db_xref="UniProtKB/Swiss-Prot:O34736" /translation="MKTITIAAEEAKELVWQKLDGAGLNERDAEKVADVLVHADLRNV HSHGVLHTEHYVNRLLAGGINPGAQPVFKETGPVTGVLDGDDGFGHVNCDMAMDHAID MAKKKGVGMVTAVNSSHCGALSYFVQKAADEKLIGMAMTHTDSIVVPFGGRTPILGTN PIAYGVPAKHKKPFILDMATSKVAFGKILQAREEGKEIPEGWGVDENGEAVTDPDKVV SLSTFGGPKGYGLSIVVDVFSGLLAGAAFGPHIAKMYNGLDQKRKLGHYVCAINPSFF TDWDTFLEQMDAMIDELQQSPPAVGFERVYVPGEIEQLHEERNKKNGISIARSVYEFL KSR*" /label="yjmC CDS" gene 1224610..1225623 /gene="yjmC" /locus_tag="BSU_12320" /old_locus_tag="BSU12320" /label="yjmC gene" CDS 1225629..1226648 /gene="yjmD" /locus_tag="BSU_12330" /old_locus_tag="BSU12330" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389115.1" /db_xref="EnsemblGenomes-Gn:BSU12330" /db_xref="EnsemblGenomes-Tr:CAB13090" /db_xref="GOA:O35045" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13207" /db_xref="UniProtKB/Swiss-Prot:O35045" /translation="MKAVQVRKAYDLVTAEVKKPVLSKDDEVLVKVKRVGICGSDMHI YHGTNPLATLPRVIGHEVTGQVEAVGANVQSLKPGDHVVIEPISYCGSCYACRKGRPN VCAKLSVFGVHEDGGMREYIVLPERQLHAVSKDLPWEEAVMAEPYTIGAQAVWRGQVE KGDTVLIQGAGPIGICVLKMAKLAGAAVMMTDLNNERLAFAKENGADAVVNVQAEHVA ERVLEWTGNEGANVVIDAVCLPETFALSIEAVSPAGHVVVLGFDERAAQISQLPITKK EVTITGSRLQTNQFPKVVELLNGGRLMHNGLVTHTFSVDDVHHAFQFIKEHPDQVRKA VITFD*" /label="yjmD CDS" gene 1225629..1226648 /gene="yjmD" /locus_tag="BSU_12330" /old_locus_tag="BSU12330" /label="yjmD gene" CDS 1226673..1227752 /gene="uxuA" /locus_tag="BSU_12340" /old_locus_tag="BSU12340" /EC_number="4.2.1.8" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 9579062, 9882655, 10368143, 25145794; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-mannonate dehydratase" /protein_id="NP_389116.1" /db_xref="EnsemblGenomes-Gn:BSU12340" /db_xref="EnsemblGenomes-Tr:CAB13091" /db_xref="GOA:O34346" /db_xref="InterPro:IPR004628" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG13208" /db_xref="UniProtKB/Swiss-Prot:O34346" /translation="MNMTFRWYGRGNDTVTLEYVKQIPGVKGIVWALHQKPVGDVWEK EEIRAETEYIQSYGFHAEVVESVNVHEAIKLGNEERGRYIENYKQTIRNLAGFGVKVI CYNFMPVFDWTRTDMFRPLEDGSTALFFEKAKVESLDPQELIRTVEEASDMTLPGWEP EKLARIKELFAAYRTVDEEKLWDNLSFFLQEILPVAEAYGVQMAIHPDDPPWPIFGLP RIITGEASYKKLRAISDSPSNCITLCTGSMGANPANDMVEIAKTYAGIAPFSHIRNVK IYENGDFIETSHLTKDGSINIQGVMEELHKQDYEGYVRPDHGRHLWGEQCRPGYGLYD RALGIMYLNGLWDAYEAMAKKEVGI*" /label="uxuA CDS" gene 1226673..1227752 /gene="uxuA" /locus_tag="BSU_12340" /old_locus_tag="BSU12340" /label="uxuA gene" CDS 1227749..1228585 /gene="uxuB" /locus_tag="BSU_12350" /old_locus_tag="BSU12350" /EC_number="1.1.1.57" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655, 10368143; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructuronate reductase" /protein_id="NP_389117.1" /db_xref="EnsemblGenomes-Gn:BSU12350" /db_xref="EnsemblGenomes-Tr:CAB13092" /db_xref="GOA:O34896" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13209" /db_xref="UniProtKB/Swiss-Prot:O34896" /translation="MIPLHENLAGKTAVITGGSGVLCSAMARELARHGMKVAILNRTA EKGQAVVKEITAAGGTACAVAADVLDRMSLERAKEDILGQFGAVDLLINGAGGNHPDA ITDVETYEEAGEGQSFFDMDERGFLTVFSTNFTGAFLASQVFGKELLKADSPAIINLS SMSAYSPMTKVPAYSAAKASINNFTMWMAVHFAETGLRVNAIAPGFFLTKQNHDLLIN QDGTFTSRSHKIIAGTPMKRFGKPEDLLGTLLWLADESYSGFVTGITVPVDGGFMAYS GV*" /label="uxuB CDS" gene 1227749..1228585 /gene="uxuB" /locus_tag="BSU_12350" /old_locus_tag="BSU12350" /label="uxuB gene" CDS 1228633..1229901 /gene="exuT" /locus_tag="BSU_12360" /old_locus_tag="BSU12360" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8320243, 9579062, 9882655, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="hexuronate transporter" /protein_id="NP_389118.1" /db_xref="EnsemblGenomes-Gn:BSU12360" /db_xref="EnsemblGenomes-Tr:CAB13093" /db_xref="GOA:O34456" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR004744" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13210" /db_xref="UniProtKB/Swiss-Prot:O34456" /translation="MFSKDKLPVILFLFLAGVINYLDRSALSIAAPFIQDDLTLSATQ MGLIFSSFSIGYAIFNFLGGVASDRYGAKLTLFVAMVVWSLFSGAVALAFGFVSLLII RILFGMGEGPLSATINKMVNNWFPPTQRASVIGVTNSGTPLGGAISGPIVGMIAVAFS WKVSFVLIMIIGLIWAVLWFKFVKEKPQETIKEAPAIKAETSPGEKIPLTFYLKQKTV LFTAFAFFAYNYILFFFLTWFPSYLVDERGLSVESMSVITVIPWILGFIGLAAGGFVS DYVYKKTARKGVLFSRKVVLVTCLFSSAVLIGFAGLVATTAGAVTLVALSVFFLYLTG AIYWAVIQDVVDQNNVGSVGGFMHFLANTAGIIGPALTGFIVDQTGTFSGAFLLAGGL AVFASLAVIRFVRPIIGKPAGTEAENPVSY*" /label="exuT CDS" gene 1228633..1229901 /gene="exuT" /locus_tag="BSU_12360" /old_locus_tag="BSU12360" /label="exuT gene" promotor_-35 1229845..1229848 /Source="Nicolas_upshift_promotors" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1229864..1229868 /Source="Nicolas_upshift_promotors" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1229866 /Source="Nicolas_upshifts" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1229934..1229953 /Source="Nicolas_upshift_promotors" /id="U1013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=3107 /SigmaFactorBS="agaagctgagaatcctgtgtcttattaatctggaaatatagt gggagaggcggtatgtttGATGATACAATATACAGTAAataatcgcagccggtatgat a" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1229934 /Source="Nicolas_upshifts" /id="U1013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=3107 /SigmaFactorBS="agaagctgagaatcctgtgtcttattaatctggaaatatagt gggagaggcggtatgtttGATGATACAATATACAGTAAataatcgcagccggtatgat a" /listShort="exuR" /GFF_Attribute="listLong" /label="upshifts" CDS 1229989..1230990 /gene="exuR" /locus_tag="BSU_12370" /old_locus_tag="BSU12370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9579062, 9882655" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9579062, 9882655; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LacI family)" /protein_id="NP_389119.1" /db_xref="EnsemblGenomes-Gn:BSU12370" /db_xref="EnsemblGenomes-Tr:CAB13094" /db_xref="GOA:Q9JMQ1" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13211" /db_xref="UniProtKB/Swiss-Prot:Q9JMQ1" /translation="MVTIKDIAKLANVSHTTVSRALNNSPYIKEHTKKKILELAEQLN YTPNVNAKSLAMQKSHTIGLFFTSITNGTSHSFFADTIKGVNQAISEDYNLYVRGIDD LKNYDSVTPMRYDGIILMSQSDIDNSFIYHIREKNIPLVVLNRDIDDRTITNILSNDK EGSQEAVEYFIQSGHQDIAIIEGIEGFKSSQQRKEGYLSALIQHHIPIKHEYSVKGQY DMESGFQAMERLLALPNPPTAVFCSNDDMAIGAMNAIFAKGLRVPDDISVIGFDDIGF SQYITPRLSTVKRPVEKISVLGAQKLLSLISEPETKAEKILENTEFMVRDSVRRLTT* " /label="exuR CDS" gene 1229989..1230990 /gene="exuR" /locus_tag="BSU_12370" /old_locus_tag="BSU12370" /label="exuR gene" promotor_no_box complement(1230672..1230772) /Source="Nicolas_upshift_promotors" /id="U1014" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.024975024975025" /xcortree=19 /SigmaFactorBS="cgcgcaggccctttgcgaatatcgcattcatcgctccgattg ccatgtcatcattcgaacaaaaaacagcggttggaggattcggcagtgccagcagccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1230712) /Source="Nicolas_upshifts" /id="U1014" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.024975024975025" /xcortree=19 /SigmaFactorBS="cgcgcaggccctttgcgaatatcgcattcatcgctccgattg ccatgtcatcattcgaacaaaaaacagcggttggaggattcggcagtgccagcagccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1230966 /Source="Nicolas_upshifts" /id="D685" /incds=0 /nref=2 /ntot=132 /MaxReadThrough="2.47166" /MaxDrop="3.11543" /score="12.2153519" /energy="-7.4" /TU="NA" /idTUdmin="U1011" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1231067..1232509 /gene="uxaB" /locus_tag="BSU_12380" /old_locus_tag="BSU12380" /EC_number="1.1.1.58" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tagaturonate reductase (altronate oxidoreductase)" /protein_id="NP_389120.1" /db_xref="EnsemblGenomes-Gn:BSU12380" /db_xref="EnsemblGenomes-Tr:CAB13095" /db_xref="GOA:O34354" /db_xref="InterPro:IPR000669" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013118" /db_xref="InterPro:IPR013131" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR023668" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13212" /db_xref="UniProtKB/Swiss-Prot:O34354" /translation="MQKLNKNVYDHYTQYPEKILQFGEGNFLRGFIDWQIDQLNQHTD FNGSVAVVQPRGSEKIKRLNEQDGLYTLFLQGMKDGEAVNEHMIINSISRGIDLFSDY EAYKELASSERLRFIISNTTEAGIVCDEKDRLEDRPQKTFPGKLTAFLYFRYQAFKGD QTKGCVLIPCELIENNGEKLRETVLHYAHLWKLEEGFTQWIHEANTFCNSLVDRIVPG FPVDSIDEITADLGYQDDLIVVGEQYYLWVIEGPDWIGKELPFAAAGLHTKIVSDLTP YRTKKVRILNGAHTAMTPVALLYGLKTVRDAVEHPEVGRFIRELIDDEILPVLKMEGL SQYADDVLNRFKNPYIKHYLESIALNAISKFKTRNLPTLKEYAEQKGQLPERLVFSFS ALLYFYHDNETLQDDPAVLQFFKEVWCQEDGDMLRIASRVLGEQRLWGADLNEIPKLT DRVAVYLNHIHELGMQRALEQYCIQGGEVR*" /label="uxaB CDS" gene 1231067..1232509 /gene="uxaB" /locus_tag="BSU_12380" /old_locus_tag="BSU12380" /label="uxaB gene" CDS 1232506..1233999 /gene="uxaA" /locus_tag="BSU_12390" /old_locus_tag="BSU12390" /EC_number="4.2.1.7" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="altronate dehydratase" /protein_id="NP_389121.2" /db_xref="EnsemblGenomes-Gn:BSU12390" /db_xref="EnsemblGenomes-Tr:CAB13096" /db_xref="GOA:O34673" /db_xref="InterPro:IPR007392" /db_xref="InterPro:IPR013974" /db_xref="SubtiList:BG13213" /db_xref="UniProtKB/Swiss-Prot:O34673" /translation="MKSFIKIHKQDNVLLALRDIQKGERLHAYGVSIEVKDDIKRGHK IALQSIKENDSIVKYGFPIGHASQDISIGEHIHVHNTKTNLSDIQLYSYTPRFDENPY SNENRTFKGFRRENGDAGVRNELWIVPTVGCVNGIAEKMLQRFVRETGDIAPFDNVLV LKHQYGCSQLGDDHENTKQILLNAIRHPNAGGVLVLGLGCENNELARMKEALQDVNLK RVKFLESQSVTDEMEAGVALLKEIHEAAKGDKREDIPLSELKIGLKCGGSDGFSGITA NPLLGRFSDYLIAQGGSTVLTEVPEMFGAETILMQRAANEEVFHKIVDLINDFKQYFI KHDQPVYENPSPGNKAGGISTLEDKSLGCTQKAGISPVTDVLKYGEVLKTKGLTLLSA PGNDLIASSALAAAGCQIVLFTTGRGTPFGTFVPTVKVATNTELYEAKPHWIDFNAGL LAEDDVHEEYVLREFIHYMIEVASGQLVNHEKNDFKELAIFKSGVTL*" /label="uxaA CDS" gene 1232506..1233999 /gene="uxaA" /locus_tag="BSU_12390" /old_locus_tag="BSU12390" /label="uxaA gene" CDS complement(1234038..1234802) /gene="yjnA" /locus_tag="Delta6_BSU_12400_SNPvariant" /old_locus_tag="BSU_12400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 16885442; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_389122.1" /db_xref="EnsemblGenomes-Gn:BSU12400" /db_xref="EnsemblGenomes-Tr:CAB13097" /db_xref="GOA:O34578" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13214" /db_xref="UniProtKB/Swiss-Prot:O34578" /modified_by="User" /translation="MSVSIILMGLFVGALVGLTGVGGAALLTPLLIVLGINPSIAVGT DLVYNSITKLFGVASHWRQKTINFKLVKYLAIGGIPSASLAIGILHLFPAFHQHQEEI IKHALGYVLTLVAISIIVRLFLDRKLRPNRWQLMPLENKRALTILIGVVFGFIVGLTS IGSGSLFAIAMIYLFNMKASQIVGTDIAHAFLLVTAAGILNASFGSVDYMLAANLLLG SIPGVLIGSHLSPRFSPRPLQFIMASIILVSGLKLI*" /label="Delta6_BSU_12400_SNPvariant" gene complement(1234038..1234802) /gene="yjnA" /locus_tag="Delta6_BSU_12400_SNPvariant" /old_locus_tag="BSU_12400" /modified_by="User" /label="Delta6_BSU_12400_SNPvariant" downshifts complement(1234057) /Source="Nicolas_upshifts" /id="D686" /incds=0 /nref=96 /ntot=170 /MaxReadThrough="1.34004" /MaxDrop="4.60564" /score="6.47747687" /energy="-11.3" /TU="NA" /idTUdmin="U1015" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" Polymorphism join(1234570,1234572) /Source="geneious" /ID="SNP_BsDelta6_1313384_1313384" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change="S -> G" /CDS_Position=232 /Change="T -> C" /Codon_Change="AGT -> GGT" /Coverage=150 /locus_tag="BSU_12400" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=149 /comment="Delta6_BSU_12400_SNPvariant" /modified_by="User" / /label="Polymorphism_Delta6" SCAR join(1234829,1234836) /created_by="User" /modified_by="User" /label="TF8A" N_region 1234830..1234835 /created_by="User" /note_="EcoRI site (GAATTC)" /modified_by="User" /label="TF8A" CDS <1234838..1235158 /gene="xlyA" /locus_tag="Delta6_pseudo_BSU_12810" /old_locus_tag="BSU12810" /EC_number="3.5.1.28" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7921239, 9555893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921239, 9555893; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage PBSX; N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_389164.1" /db_xref="EnsemblGenomes-Gn:BSU12810" /db_xref="EnsemblGenomes-Tr:CAB13138" /db_xref="GOA:P39800" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR002502" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="InterPro:IPR036505" /db_xref="InterPro:IPR036779" /db_xref="PDB:3HMB" /db_xref="PDB:3RDR" /db_xref="SubtiList:BG10962" /db_xref="UniProtKB/Swiss-Prot:P39800" /NCBI_locus_tag="A8O17_RS06625" /modified_by="User" /translation="PNLIRVGQVLIVSAPSAAEKPELYPLPDGIIQLTTPYTSGEHVF QVQRALAALYFYPDKGAVNNGIDGVYGPKTADAVARFQSVNGLTADGIYGPATKEKIA AQLS*" /label="Delta6_pseudo_BSU_12810" gene <1234838..1235158 /gene="xlyA" /locus_tag="Delta6_pseudo_BSU_12810" /old_locus_tag="BSU12810" /NCBI_locus_tag="A8O17_RS06625" /modified_by="User" /label="Delta6_pseudo_BSU_12810" downshifts 1235167 /Source="Nicolas_upshifts" /id="D696" /incds=0 /nref=29 /ntot=162 /MaxReadThrough="3.77255" /MaxDrop="5.00305" /score="30.9009227" /energy="-12.5" /TU="U1029,U1033" /idTUdmin="U1029" /TUdmin="-152" /isTUend="FALSE" /label="downshifts" S_feature complement(1235176..1235379) /Source="Nicolas_S_feature" /locus_tag="new_1348200_1348403_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, G/S, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.798" /TUlongSig="NA" /TUlongPSig="NA" /label="S458" CDS complement(1235195..1235332) /gene="spoIISC" /locus_tag="BSU_12815" /old_locus_tag="BSU12815" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type r: regulator" /codon_start=1 /transl_table=11 /product="three component toxin / antitoxin / antitoxin SpoIISABC, antitoxin C" /protein_id="YP_009513952.1" /translation="MSGDTVKKLVRRVKFVDYGRFGLSGYSLRVRERSAGIIKKLKKK K*" /label="spoIISC CDS" gene complement(1235195..1235332) /gene="spoIISC" /locus_tag="BSU_12815" /old_locus_tag="BSU12815" /label="spoIISC gene" downshifts complement(1235219) /Source="Nicolas_upshifts" /id="D697" /incds=0 /nref=31 /ntot=215 /MaxReadThrough="2.75573" /MaxDrop="4.3776" /score="24.0186344" /energy="-12.5" /TU="U1034" /idTUdmin="U1035" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1235418..1235588) /gene="spoIISB" /locus_tag="BSU_12820" /old_locus_tag="BSU12820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type f: factor" /codon_start=1 /transl_table=11 /product="three-component apoptotic control system component B (antitoxin B)" /protein_id="NP_389165.1" /db_xref="EnsemblGenomes-Gn:BSU12820" /db_xref="EnsemblGenomes-Tr:CAB13139" /db_xref="GOA:O34800" /db_xref="InterPro:IPR025897" /db_xref="PDB:3O6Q" /db_xref="SubtiList:BG12678" /db_xref="UniProtKB/Swiss-Prot:O34800" /translation="MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKEN ERLIDEYKRKKA*" /label="spoIISB CDS" gene complement(1235418..1235588) /gene="spoIISB" /locus_tag="BSU_12820" /old_locus_tag="BSU12820" /label="spoIISB gene" downshifts complement(1235424) /Source="Nicolas_upshifts" /id="D698" /incds=0 /nref=6 /ntot=86 /MaxReadThrough="4.69899" /MaxDrop="3.0872" /score="24.0186344" /energy="-12.5" /TU="U1034,U1035" /idTUdmin="U1035" /TUdmin="-205" /isTUend="FALSE" /label="downshifts" CDS complement(1235588..1236334) /gene="spoIISA" /locus_tag="BSU_12830" /old_locus_tag="BSU12830" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type f: factor" /codon_start=1 /transl_table=11 /product="three-component apoptosis factor (ABC toxin/antitoxin/antitoxin system)" /protein_id="NP_389166.1" /db_xref="EnsemblGenomes-Gn:BSU12830" /db_xref="EnsemblGenomes-Tr:CAB13140" /db_xref="GOA:O34853" /db_xref="InterPro:IPR025940" /db_xref="PDB:3O6Q" /db_xref="SubtiList:BG12677" /db_xref="UniProtKB/Swiss-Prot:O34853" /translation="MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLL FVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAFIFLSAYVKKLAGSELETDTREI LEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSD SIVTEFDYLLFTSLTSIYDLVLPIEEEGEG*" /label="spoIISA CDS" gene complement(1235588..1236334) /gene="spoIISA" /locus_tag="BSU_12830" /old_locus_tag="BSU12830" /label="spoIISA gene" promotor_-10 complement(1236169..1236188) /Source="Nicolas_upshift_promotors" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1236186) /Source="Nicolas_upshifts" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1236204..1236211) /Source="Nicolas_upshift_promotors" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1236360..1236378) /Source="Nicolas_upshift_promotors" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1236373) /Source="Nicolas_upshifts" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1236394..1236399) /Source="Nicolas_upshift_promotors" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1236444..1237445) /gene="pitB" /locus_tag="BSU_12840" /old_locus_tag="BSU12840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10784039, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative low-affinity inorganic phosphate transporter" /protein_id="NP_389167.2" /db_xref="EnsemblGenomes-Gn:BSU12840" /db_xref="EnsemblGenomes-Tr:CAB13141" /db_xref="GOA:O34436" /db_xref="InterPro:IPR001204" /db_xref="SubtiList:BG13226" /db_xref="UniProtKB/Swiss-Prot:O34436" /translation="MDILLILTILIVICALAFDFINGFHDTANAIATSVSTKALKPRH AIILAAVMNFVGAMTFTGVAKTITKDIVDPYTLENGSVVILAALLAAIAWNLITWYYG IPSSSSHAIIGAIAGAAIAAAGFAALNYKGFIKIIEALILSPIIAFVLGFILYSIVKL IFKDSNLAKTNKQFRRVQIVTAALQSYTHGTNDAQKAMGIITMALITANLHTSANDIP TWVQFACATAMGLGTSIGGWKIIKTVGGKIMKIRPVNGVSADLTGAAIIFGATFIHLP VSTTHVISSSILGVGASHRVKGVNWGTAKRMLITWVITLPISATLGAIAYFILNMIF* " /label="pitB CDS" gene complement(1236444..1237445) /gene="pitB" /locus_tag="BSU_12840" /old_locus_tag="BSU12840" /label="pitB gene" downshifts complement(1236473) /Source="Nicolas_upshifts" /id="D699" /incds=0 /nref=205 /ntot=253 /MaxReadThrough="3.49591" /MaxDrop="5.81942" /score="21.8061263" /energy="-11" /TU="U1036,U1038" /idTUdmin="U1037" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1237458..1238075) /gene="ykaA" /locus_tag="BSU_12850" /old_locus_tag="BSU12850" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9696772, 14563871; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PitB transporter accessory protein" /protein_id="NP_389168.1" /db_xref="EnsemblGenomes-Gn:BSU12850" /db_xref="EnsemblGenomes-Tr:CAB13142" /db_xref="InterPro:IPR018445" /db_xref="SubtiList:BG13225" /db_xref="UniProtKB/Swiss-Prot:O34454" /translation="MIRRKKDKFSLLLTEIAKNIDETAEYFVNFKVTNQTTLKEFADT LKEYETKGDNHVHVMIKELNKAFITPIEREDILQLTNSLDDVLDGIEHFSAMMEIFSI TSSDEHIDKFSGYIRECAKEILITIELLAENRLKDIQPHAIKIKEYEHSCDNLHRKSL KNLFGNETDPIKVIQYREIYETLEEIADSCQSVANNLETIIMKNA*" /label="ykaA CDS" gene complement(1237458..1238075) /gene="ykaA" /locus_tag="BSU_12850" /old_locus_tag="BSU12850" /label="ykaA gene" promotor_-10 complement(1238111..1238130) /Source="Nicolas_upshift_promotors" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1238113) /Source="Nicolas_upshifts" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1238115..1238212) /Source="Nicolas_S_feature" /locus_tag="new_1351139_1351236_c" /HighExp="H2O2, Etha, dia15, Diami, Paraq, Heat, dia5, Salt, LBGstat, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.972, 0.987" /TUlongSig="SigA" /TUlongPSig="0.992" /label="S459" promotor_-35 complement(1238146..1238150) /Source="Nicolas_upshift_promotors" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1238192..1238211) /Source="Nicolas_upshift_promotors" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1238212) /Source="Nicolas_upshifts" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1238226..1238233) /Source="Nicolas_upshift_promotors" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1238257..1238276) /Source="Nicolas_upshift_promotors" /id="U1038" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.677322677322677" /psig="0.987012987012987" /xcortree=1829 /SigmaFactorBS="ggaaccgttttttggtgaaacagaagataaaagttgacagga aaaacacaactTTTGATATACTTTTTACGTTaagcagaaagtttttgcaaacttgggt c" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1238269) /Source="Nicolas_upshifts" /id="U1038" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.677322677322677" /psig="0.987012987012987" /xcortree=1829 /SigmaFactorBS="ggaaccgttttttggtgaaacagaagataaaagttgacagga aaaacacaactTTTGATATACTTTTTACGTTaagcagaaagtttttgcaaacttgggt c" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1238351..1239667) /gene="steT" /locus_tag="BSU_12860" /old_locus_tag="BSU12860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17344220, 19419962, 20610400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17344220, 19419962, 20610400; Product type t : transporter" /codon_start=1 /transl_table=11 /product="serine / threonine exchanger" /protein_id="NP_389169.1" /db_xref="EnsemblGenomes-Gn:BSU12860" /db_xref="EnsemblGenomes-Tr:CAB13143" /db_xref="GOA:O34739" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG13227" /db_xref="UniProtKB/Swiss-Prot:O34739" /translation="MHTEDNGLKKEIGLLFALTLVIGTIIGSGVFMKPGAVLAYSGDS KMALFAWLLGGILTLAGGLTIAEIGTQIPKTGGLYTYLEEVYGEFWGFLCGWVQIIIY GPAIIGALGLYFGSLMANLFGWGSGLSKVIGIIAVLFLCVINIIGTKYGGFVQTLTTI GKLIPIACIIVFGLWKGDQHIFTAVNESISDMNFGAAILATLFAYDGWILLAALGGEM KNPEKLLPRAMTGGLLIVTAIYIFINFALLHILSANEIVTLGENATSTAATMLFGSIG GKLISVGIIVSIFGCLNGKVLSFPRVSFAMAERKQLPFAEKLSHVHPSFRTPWIAISF QIALALIMMLISNPDKLSEISIFMIYIFYVMAFFAVFILRKRAKGEKRAYSVPLYPFM PILAIAGSFFVLGSTLITDTMSCGLSILIGLAGLPVYYGMKKRKAS*" /label="steT CDS" gene complement(1238351..1239667) /gene="steT" /locus_tag="BSU_12860" /old_locus_tag="BSU12860" /label="steT gene" downshifts complement(1238366) /Source="Nicolas_upshifts" /id="D700" /incds=0 /nref=3 /ntot=92 /MaxReadThrough="3.59461" /MaxDrop="3.97157" /score="23.3119204" /energy="-14.4" /TU="U1039" /idTUdmin="U1039" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1239714..1239733) /Source="Nicolas_upshift_promotors" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="promotor_-10" upshifts complement(1239730) /Source="Nicolas_upshifts" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="upshifts" promotor_-35 complement(1239748..1239751) /Source="Nicolas_upshift_promotors" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="promotor_-35" promotor_-35 1239950..1239957 /Source="Nicolas_upshift_promotors" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1239972..1239991 /Source="Nicolas_upshift_promotors" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1239984..1240055 /Source="Nicolas_S_feature" /locus_tag="new_1353008_1353079" /HighExp="Etha, dia15, Salt, Heat, dia5, Diami, H2O2, M9-stat, MG 25, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.964" /TUlongSig="NA" /TUlongPSig="NA" /label="S460" upshifts 1239984 /Source="Nicolas_upshifts" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="upshifts" CDS 1240056..1241006 /gene="mhqA" /locus_tag="BSU_12870" /old_locus_tag="BSU12870" /EC_number="1.13.11.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:17407181, 17725564" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17407181, 17725564; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroquinone-specific extradiol dioxygenase" /protein_id="NP_389170.1" /db_xref="EnsemblGenomes-Gn:BSU12870" /db_xref="EnsemblGenomes-Tr:CAB13144" /db_xref="GOA:O34689" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13228" /db_xref="UniProtKB/Swiss-Prot:O34689" /translation="MKVNGIHHVSALTADAQKNLDFYKKVLGLKLVKKSVNQDEPTMY HLFYGDEVANPGTELTFFEIPRIAPFHAGTNSISSIGLRVPGTEALHYWKERFEEQQV THSGISKRAGRDILAFQDHEGQRLVLTADEEGKGYGLPVKQSGIPEEFSFRGLGPVEL TVPYAEPTLHVLTNILGFTEISREPVEGQGTAVILESGEGGAATEIHLIERNDLPRER QGKGSVHHVAFRVRDEEELAGWHRIISREGFSNSGIVERYYFKALYFREPNGILFELS TDGPGFMVDENLDELGQTIALPPYLEHRRAEIEAKLKPIQ*" /label="mhqA CDS" gene 1240056..1241006 /gene="mhqA" /locus_tag="BSU_12870" /old_locus_tag="BSU12870" /label="mhqA gene" downshifts 1240994 /Source="Nicolas_upshifts" /id="D701" /incds=0 /nref=95 /ntot=231 /MaxReadThrough="0.70251" /MaxDrop="5.11652" /score="51.2936135" /energy="-17.5" /TU="NA" /idTUdmin="U1040" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS 1241107..1241253 /locus_tag="BSU_12875" /old_locus_tag="BSU12875" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513953.1" /translation="MLIGRNGLKPFANMGDWYGMASAKILSLFINSLFIFACYTISKL DKKE*" /label="hypothetical protein CDS" gene 1241107..1241253 /locus_tag="BSU_12875" /old_locus_tag="BSU12875" /label="gene" CDS 1241261..1243411 /gene="ykcB" /locus_tag="BSU_12880" /old_locus_tag="BSU12880" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 18175906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane glycosyl transferase" /protein_id="NP_389171.2" /db_xref="EnsemblGenomes-Gn:BSU12880" /db_xref="EnsemblGenomes-Tr:CAB13145" /db_xref="GOA:O34575" /db_xref="SubtiList:BG13229" /db_xref="UniProtKB/Swiss-Prot:O34575" /translation="MEKKKRELDIVLLLILLASAFLNIYNIWKDDTVNPYYTAAVTSM MQSFHNFFYASFDAAGFITVDKPPVTYQIQTISALIFGMHGWSVILPQALAGVGSVLL MYLLIKPTFGKTAARIASFVMACTPIAVAVARTNNVDALLVFFLLLATWLLFKAIRKG KLIWLLAAFFVVGVGFNTKMLQAYMILPAFLLFYLIAANATIKKKIVSLVSALAVLAA VSLSWPLIVDNIPASKRPYIGSSQTNSVLELAFGYNGIQRLTGQNSGGGQGAPNKDAS KEMSSSDNTQAPPNQSSSNSSSSDGKSSNGNMAAPPSNGQMPSGGQGGPPSGGDGGQG GPGGDGGKGGTGTGSKMQSGSGMFGTGTPGPLRLFQQELSDQISWLLPFAIFGIAGLL IAGARERRRLSVEQKETVFWVAWLVPIAGFFSVAEFFHHYYLIMLAPPIAALVGAGWV ALVHLYRNQTGWKAWLLPGAIIATTGFELFILRNYNDQIGVGWSIGVGVIGVLSAIAL LLFKQRQKPFSYYVSLAALLALLVMPMYWASTPLLYGGNSSLPETGPQLASMSGKGMG MSDATVNEKLIKYLEENNSGAEYLFATTDSNTAAPYIIKTKKAVMAIGGYSGSDPAIT LTQFKKLVKEGKVKYFLASGMGRGGNNDIVEWVEKNGKEVASEKWQSSSDQKTENTDS ADTSSSKASGENGKMGGPGGMNQSATLYELHADE*" /label="ykcB CDS" gene 1241261..1243411 /gene="ykcB" /locus_tag="BSU_12880" /old_locus_tag="BSU12880" /label="ykcB gene" promotor_no_box 1242150..1242250 /Source="Nicolas_upshift_promotors" /id="U1041" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.000999000999001" /xcortree=1488 /SigmaFactorBS="catcaagcgatggtaaatcctcaaatggcaatatggcggcgc ctccatccaatggccaaatgccaagcggcggtcaaggaggccctccaagcggcggaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1242210 /Source="Nicolas_upshifts" /id="U1041" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.000999000999001" /xcortree=1488 /SigmaFactorBS="catcaagcgatggtaaatcctcaaatggcaatatggcggcgc ctccatccaatggccaaatgccaagcggcggtcaaggaggccctccaagcggcggaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1242298 /Source="Nicolas_upshifts" /id="D702" /incds=1 /nref=4 /ntot=10 /MaxReadThrough="0.56615" /MaxDrop="4.44711" /score="51.2936135" /energy="-17.5" /TU="NA" /idTUdmin="U1041" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1243423..1244394 /gene="ykcC" /locus_tag="BSU_12890" /old_locus_tag="BSU12890" /EC_number="2.4.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389172.2" /db_xref="EnsemblGenomes-Gn:BSU12890" /db_xref="EnsemblGenomes-Tr:CAB13146" /db_xref="GOA:O34319" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13230" /db_xref="UniProtKB/Swiss-Prot:O34319" /translation="MSRHIQYSIVVPVYNEELVIHETYQRLKEVMDQTKENYELLFVN DGSKDRSIEILREHSLIDPRVKIIDFSRNFGHQIAITAGMDYAQGNAIVVIDADLQDP PELILEMIEKWKEGYEVVYAVRTKRKGETFFKKQTAAMFYRLLSGMTDIDIPIDTGDF RLMDRKVCDEMKRLKEKNPFVRGLVSWVGFKQTAVEYVRDERLAGETKYPLKKMLKLS MDGITTFSHKPLKLASYAGILMSGTGFLYMFIVLYLKLFTDSTITGWSSLIVIQLLFS GIVLLILGVIGEYIGRIYDEAKDRPLYIVQKSYGIENKRLYRDQHMS*" /label="ykcC CDS" gene 1243423..1244394 /gene="ykcC" /locus_tag="BSU_12890" /old_locus_tag="BSU12890" /label="ykcC gene" S_feature complement(1243751..1244392) /Source="Nicolas_S_feature" /locus_tag="new_1356775_1357416_c" /HighExp="T-0.40H, T0.0H, Salt, T0.30H, T-1.10H, C30, T-1.40H, S0, H2O2, T1.0H" /AntisenseName="ykcC" /AntisenseCor="9.6017422892053297E-4" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S461" downshifts complement(1244437) /Source="Nicolas_upshifts" /id="D703" /incds=0 /nref=9 /ntot=114 /MaxReadThrough="4.36795" /MaxDrop="4.15844" /score="4.98888048" /energy="-19.1" /TU="U1042" /idTUdmin="U1044" /TUdmin=489 /isTUend="FALSE" /label="downshifts" S_feature complement(1244462..1244828) /Source="Nicolas_S_feature" /locus_tag="new_1357486_1357852_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T0.0H, T2.30H, T-0.40H, T3.0H, Salt, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99893799999999999" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S462" downshifts complement(1244505) /Source="Nicolas_upshifts" /id="D704" /incds=0 /nref=17 /ntot=157 /MaxReadThrough="6.61192" /MaxDrop="3.74411" /score="4.98888048" /energy="-19.1" /TU="U1042" /idTUdmin="U1044" /TUdmin=421 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1244808..1244823) /Source="Nicolas_upshift_promotors" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1244828) /Source="Nicolas_upshifts" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1244835..1244844) /Source="Nicolas_upshift_promotors" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1244912..1246261) /gene="htrA" /locus_tag="BSU_12900" /old_locus_tag="BSU12900" /EC_number="3.4.21.107" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10692364, 11133960, 11555295, 12823817, 24362423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10692364, 11133960, 11555295, 12823817, 24362423; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane bound serine protease Do, quality control protease and chaperone (heat-shock protein)" /protein_id="NP_389173.2" /db_xref="EnsemblGenomes-Gn:BSU12900" /db_xref="EnsemblGenomes-Tr:CAB13147" /db_xref="GOA:O34358" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG12608" /db_xref="UniProtKB/Swiss-Prot:O34358" /translation="MDNYRDENRTKGNENEVFLTKENDQSASYSARNVIHDQEKKKRG FGWFRPLLGGVIGGSLALGIYTFTPLGDHDSQDTAKQSSSQQQTQSVTATSTSSESKK SSSSSSAFKSEDSSKISDMVEDLSPAIVGITNLQAQSNSSLFGSSSSDSSEDTESGSG SGVIFKKENGKAYIITNNHVVEGASSLKVSLYDGTEVTAKLVGSDSLTDLAVLQISDD HVTKVANFGDSSDLRTGETVIAIGDPLGKDLSRTVTQGIVSGVDRTVSMSTSAGETSI NVIQTDAAINPGNSGGPLLNTDGKIVGINSMKISEDDVEGIGFAIPSNDVKPIAEELL SKGQIERPYIGVSMLDLEQVPQNYQEGTLGLFGSQLNKGVYIREVASGSPAEKAGLKA EDIIIGLKGKEIDTGSELRNILYKDAKIGDTVEVKILRNGKEMTKKIKLDQKEEKTS* " /label="htrA CDS" gene complement(1244912..1246261) /gene="htrA" /locus_tag="BSU_12900" /old_locus_tag="BSU12900" /label="htrA gene" downshifts complement(1244926) /Source="Nicolas_upshifts" /id="D705" /incds=0 /nref=198 /ntot=244 /MaxReadThrough="2.95586" /MaxDrop="5.35972" /score="30.7234179" /energy="-19.9" /TU="NA" /idTUdmin="U1044" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1246301..1246308 /Source="Nicolas_upshift_promotors" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="promotor_-35" promotor_-10 complement(1246313..1246332) /Source="Nicolas_upshift_promotors" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1246321 /Source="Nicolas_upshifts" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="upshifts" promotor_-10 1246323..1246342 /Source="Nicolas_upshift_promotors" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="promotor_-10" upshifts complement(1246331) /Source="Nicolas_upshifts" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1246333..1246415) /Source="Nicolas_S_feature" /locus_tag="new_1359357_1359439_c" /HighExp="Etha, dia5, S8, S6, T2.0H, T3.30H, dia15, T5.0H, BC, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.682" /TUlongSig="NA" /TUlongPSig="NA" /label="S463" promotor_-35 complement(1246343..1246350) /Source="Nicolas_upshift_promotors" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1246372..1246378 /Source="Nicolas_upshift_promotors" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1246393..1246412 /Source="Nicolas_upshift_promotors" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1246396 /Source="Nicolas_upshifts" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1246398..1246417) /Source="Nicolas_upshift_promotors" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1246415) /Source="Nicolas_upshifts" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="upshifts" CDS 1246430..1247248 /gene="proCC" /locus_tag="BSU_12910" /old_locus_tag="BSU12910" /EC_number="1.5.1.2" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="redundant pyrroline-5-carboxylate reductase" /protein_id="NP_389174.1" /db_xref="EnsemblGenomes-Gn:BSU12910" /db_xref="EnsemblGenomes-Tr:CAB13148" /db_xref="GOA:Q00777" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10841" /db_xref="UniProtKB/Swiss-Prot:Q00777" /translation="MEQIGLIGYGSMADMIARQLLKHEQIKENELFIETRTKGERLRA LMSDYPNVSADPLENWANTCQLILICVPPLHVIETMRRLYPYVNRNTHIVSIAAGVPL RLLEAETEAGISRVIPAITSEAEAGISLVVHSEALAAEKKERLNELLSVFSRVREIKE SNLDVASNLTSSAPGFIAAIFEELALSAVRNSSLSKEEAFDFLIHSLYGTGKMLIEKN MSFEETLERVATKGGITGEGAEVIHASVPDVFDEVFERTLRKYELLTEQVGKQT*" /label="proCC CDS" gene 1246430..1247248 /gene="proCC" /locus_tag="BSU_12910" /old_locus_tag="BSU12910" /label="proCC gene" promotor_-35 complement(1246433..1246436) /Source="Nicolas_upshift_promotors" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1247226 /Source="Nicolas_upshifts" /id="D706" /incds=0 /nref=90 /ntot=220 /MaxReadThrough="1.3818" /MaxDrop="4.43155" /score="-5.08770006" /energy="-5.3" /TU="NA" /idTUdmin="U1045" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1247305..1247312 /Source="Nicolas_upshift_promotors" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1247327..1247346 /Source="Nicolas_upshift_promotors" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1247331 /Source="Nicolas_upshifts" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="upshifts" CDS 1247377..1248201 /gene="dppA" /locus_tag="BSU_12920" /old_locus_tag="BSU12920" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11069674, 11473256, 19340926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069674, 11473256, 19340926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-aminopeptidase" /protein_id="NP_389175.2" /db_xref="EnsemblGenomes-Gn:BSU12920" /db_xref="EnsemblGenomes-Tr:CAB13149" /db_xref="GOA:P26902" /db_xref="InterPro:IPR007035" /db_xref="InterPro:IPR027476" /db_xref="InterPro:IPR033824" /db_xref="InterPro:IPR036177" /db_xref="PDB:1HI9" /db_xref="SubtiList:BG10842" /db_xref="UniProtKB/Swiss-Prot:P26902" /translation="MKLYMSVDMEGISGLPDDTFVDSGKRNYERGRLIMTEEANYCIA EAFNSGCTEVLVNDSHSKMNNLMVEKLHPEADLISGDVKPFSMVEGLDDTFRGALFLG YHARASTPGVMSHSMIFGVRHFYINDRPVGELGLNAYVAGYYDVPVLMVAGDDRAAKE AEELIPNVTTAAVKQTISRSAVKCLSPAKAGRLLTEKTAFALQNKDKVKPLTPPDRPV LSIEFANYGQAEWANLMPGTEIKTGTTTVQFQAKDMLEAYQAMLVMTELAMRTSFC*" /label="dppA CDS" gene 1247377..1248201 /gene="dppA" /locus_tag="BSU_12920" /old_locus_tag="BSU12920" /label="dppA gene" CDS 1248218..1249144 /gene="dppB" /locus_tag="BSU_12930" /old_locus_tag="BSU12930" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1766370, 7536291, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766370, 7536291, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (permease)" /protein_id="NP_389176.1" /db_xref="EnsemblGenomes-Gn:BSU12930" /db_xref="EnsemblGenomes-Tr:CAB13150" /db_xref="GOA:P26903" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10843" /db_xref="UniProtKB/Swiss-Prot:P26903" /translation="MARYMIKRFWAMAATILVITTLTFVLMKVIPGSPFNEERGTNEA VQKNLEAYYHLDDPLIFQYIFYLKSIITFDFGPSIKKPSDSVNDMLERGFPVSFELGM TAIVIAVISGLVLGVIAALRRNGFLDYAAMSLAVLGISIPNFILATLLIQQFAVNLKL FPAATWTSPIHMVLPTAALAVGPMAIIARLTRSSMVEVLTQDYIRTAKAKGLSPFKII VKHALRNALMPVITVLGTLVASILTGSFVIEKIFAIPGMGKYFVESINQRDYPVIMGT TVFYSVILIIMLFLVDLAYGLLDPRIKLHKKG*" /label="dppB CDS" gene 1248218..1249144 /gene="dppB" /locus_tag="BSU_12930" /old_locus_tag="BSU12930" /label="dppB gene" CDS 1249150..1250112 /gene="dppC" /locus_tag="BSU_12940" /old_locus_tag="BSU12940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1766370, 7536291, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766370, 7536291, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (permease)" /protein_id="NP_389177.1" /db_xref="EnsemblGenomes-Gn:BSU12940" /db_xref="EnsemblGenomes-Tr:CAB13151" /db_xref="GOA:P26904" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10844" /db_xref="UniProtKB/Swiss-Prot:P26904" /translation="MNLPVQTDERQPEQHNQVPDEWFVLNQEKNREADSVKRPSLSYT QDAWRRLKKNKLAMAGLFILLFLFVMAVIGPFLSPHSVVRQSLTEQNLPPSADHWFGT DELGRDVFTRTWYGARISLFVGVMAALIDFLIGVIYGGVAGYKGGRIDSIMMRIIEVL YGLPYLLVVILLMVLMGPGLGTIIVALTVTGWVGMARIVRGQVLQIKNYEYVLASKTF GAKTFRIIRKNLLPNTMGAIIVQMTLTVPAAIFAESFLSFLGLGIQAPFASWGVMAND GLPTILSGHWWRLFFPAFFISLTMYAFNVLGDGLQDALDPKLRR*" /label="dppC CDS" gene 1249150..1250112 /gene="dppC" /locus_tag="BSU_12940" /old_locus_tag="BSU12940" /label="dppC gene" promotor_-35 1249844..1249849 /Source="Nicolas_upshift_promotors" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1249865..1249883 /Source="Nicolas_upshift_promotors" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1249866 /Source="Nicolas_upshifts" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="upshifts" CDS 1250117..1251124 /gene="dppD" /locus_tag="BSU_12950" /old_locus_tag="BSU12950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7536291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7536291; Product type t : transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (ATP-binding subunit)" /protein_id="NP_389178.1" /db_xref="EnsemblGenomes-Gn:BSU12950" /db_xref="EnsemblGenomes-Tr:CAB13152" /db_xref="GOA:P26905" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10845" /db_xref="UniProtKB/Swiss-Prot:P26905" /translation="MEKVLSVQNLHVSFTTYGGTVQAVRGVSFDLYKGETFAIVGESG CGKSVTSQSIMGLLPPYSAKVTDGRILFKNKDLCRLSDKEMRGIRGADISMIFQDPMT ALNPTLTVGDQLGEALLRHKKMSKKAARKEVLSMLSLVGIPDPGERLKQYPHQFSGGM RQRIVIAMALICEPDILIADEPTTALDVTIQAQILELFKEIQRKTDVSVILITHDLGV VAQVADRVAVMYAGKMAEIGTRKDIFYQPQHPYTKGLLGSVPRLDLNGAELTPIDGTP PDLFSPPPGCPFAARCPNRMVVCDRVYPGQTIRSDSHTVNCWLQDQRAEHAVLSGDAK D*" /label="dppD CDS" gene 1250117..1251124 /gene="dppD" /locus_tag="BSU_12950" /old_locus_tag="BSU12950" /label="dppD gene" CDS 1251127..1252776 /gene="dppE" /locus_tag="BSU_12960" /old_locus_tag="BSU12960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7783641, 8793880, 11390694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783641, 8793880, 11390694; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (dipeptide-binding lipoprotein)" /protein_id="NP_389179.2" /db_xref="EnsemblGenomes-Gn:BSU12960" /db_xref="EnsemblGenomes-Tr:CAB13153" /db_xref="GOA:P26906" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR023765" /db_xref="InterPro:IPR030678" /db_xref="SubtiList:BG10846" /db_xref="UniProtKB/Swiss-Prot:P26906" /translation="MKRGKRMKRVKKLWGMGLALGLSFALMGCTANEQAGKEGSHDKA KTSGEKVLYVNNENEPTSFDPPIGFNNVSWQPLNNIMEGLTRLGKDHEPEPAMAEKWS VSKDNKTYTFTIRENAKWTNGDPVTAGDFEYAWKRMLDPKKGASSAFLGYFIEGGEAY NSGKGKKDDVKVTAKDDRTLEVTLEAPQKYFLSVVSNPAYFPVNEKVDKDNPKWFAES DTFVGNGPFKLTEWKHDDSITMEKSDTYWDKDTVKLDKVKWAMVSDRNTDYQMFQSGE LDTAYVPAELSDQLLDQDNVNIVDQAGLYFYRFNVNMEPFQNENIRKAFAMAVDQEEI VKYVTKNNEKPAHAFVSPGFTQPDGKDFREAGGDLIKPNESKAKQLLEKGMKEENYNK LPAITLTYSTKPEHKKIAEAIQQKLKNSLGVDVKLANMEWNVFLEDQKALKFQFSQSS FLPDYADPISFLEAFQTGNSMNRTGWANKEYDQLIKQAKNEADEKTRFSLMHQAEELL INEAPIIPVYFYNQVHLQNEQVKGIVRHPVGYIDLKWADKN*" /label="dppE CDS" gene 1251127..1252776 /gene="dppE" /locus_tag="BSU_12960" /old_locus_tag="BSU12960" /label="dppE gene" downshifts 1252770 /Source="Nicolas_upshifts" /id="D707" /incds=0 /nref=2 /ntot=25 /MaxReadThrough="6.73127" /MaxDrop="3.5888" /score="22.838155" /energy="-13.9" /TU="U1047,U1048" /idTUdmin="U1048" /TUdmin="-4469" /isTUend="FALSE" /label="downshifts" CDS 1252864..1253823 /gene="ldcA" /locus_tag="BSU_12970" /old_locus_tag="BSU12970" /EC_number="3.4.17.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10428950, 15101989, 18535144, 20944232, 24123814; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="muropeptide L,D-carboxypeptidase" /protein_id="NP_389180.2" /db_xref="EnsemblGenomes-Gn:BSU12970" /db_xref="EnsemblGenomes-Tr:CAB13154" /db_xref="GOA:O34851" /db_xref="InterPro:IPR003507" /db_xref="InterPro:IPR027461" /db_xref="InterPro:IPR027478" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13231" /db_xref="UniProtKB/Swiss-Prot:O34851" /translation="MKGVFSLNYKPKALNKGDTVGVIAPASPPDPKKLDTALLFLEEL GLQVKLGKALKNQHGYLAGQDDERLADLHEMFRDDEVKAVLCACGGFGTGRIAAGIDF SLIRKHPKIFWGYSDITFLHTAIHQNTGLVTFHGPMLSTDIGLDDVHPLTKASYKQLF QETEFTYTEELSPLTELVPGKAEGELVGGNLSLLTSTLGTPFEIDTRGKLLFIEDIDE EPYQIDRMLNQLKMGGKLTDAAGILVCDFHNCVPVKREKSLSLEQVLEDYIISAGRPA LRGFKIGHCSPSIAVPIGAKAAMNTAEKTAVIEAGVSEGALKT*" /label="ldcA CDS" gene 1252864..1253823 /gene="ldcA" /locus_tag="BSU_12970" /old_locus_tag="BSU12970" /label="ldcA gene" CDS 1253820..1254920 /gene="aeeB" /locus_tag="BSU_12980" /old_locus_tag="BSU12980" /EC_number="5.1.1.20" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11747447, 11747448, 15101989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11747447, 11747448, 15101989; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-Ala-D/L-Glu epimerase" /protein_id="NP_389181.1" /db_xref="EnsemblGenomes-Gn:BSU12980" /db_xref="EnsemblGenomes-Tr:CAB13155" /db_xref="GOA:O34508" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="PDB:1JPM" /db_xref="PDB:1TKK" /db_xref="SubtiList:BG13232" /db_xref="UniProtKB/Swiss-Prot:O34508" /translation="MKIIRIETSRIAVPLTKPFKTALRTVYTAESVIVRITYDSGAVG WGEAPPTLVITGDSMDSIESAIHHVLKPALLGKSLAGYEAILHDIQHLLTGNMSAKAA VEMALYDGWAQMCGLPLYQMLGGYRDTLETDYTVSVNSPEEMAADAENYLKQGFQTLK IKVGKDDIATDIARIQEIRKRVGSAVKLRLDANQGWRPKEAVTAIRKMEDAGLGIELV EQPVHKDDLAGLKKVTDATDTPIMADESVFTPRQAFEVLQTRSADLINIKLMKAGGIS GAEKINAMAEACGVECMVGSMIETKLGITAAAHFAASKRNITRFDFDAPLMLKTDVFN GGITYSGSTISMPGKPGLGIIGAALLKGEKEQ*" /label="aeeB CDS" gene 1253820..1254920 /gene="aeeB" /locus_tag="BSU_12980" /old_locus_tag="BSU12980" /label="aeeB gene" CDS 1254917..1255807 /gene="eepC" /locus_tag="BSU_12990" /old_locus_tag="BSU12990" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15101989, 20944232" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 20944232; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gamma-D-glutamyl-L-diaminoacid endopeptidase" /protein_id="NP_389182.2" /db_xref="EnsemblGenomes-Gn:BSU12990" /db_xref="EnsemblGenomes-Tr:CAB13156" /db_xref="GOA:O35010" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG13233" /db_xref="UniProtKB/Swiss-Prot:O35010" /translation="MMHTVISAVANIWTAPDSPRPSDQFMLQPTVMIRDWLERMTYDE RLGLCTDNVIQTQVLFGEKVLVTAEQGEWVSVIVPSQPSRKDPRGYPGWMKKYQLEKT KPIHTQHDVMISKPAAFLYRSNGEKEIELSFLTVLPLIAKENGYFKVSTVFGERFVRQ SDAVPVSQQKGTAEDIIQTGAFFLGLPYLWGGISGFGFDCSGFMYSIFKANGYSIPRD AGDQAKAGKGVPLDDMKAGDLLFFAYEEGKGAIHHVGLYVGGGKMLHSPKTGKSIEIL TLTETIYEKELCAVRRCFSE*" /label="eepC CDS" gene 1254917..1255807 /gene="eepC" /locus_tag="BSU_12990" /old_locus_tag="BSU12990" /label="eepC gene" CDS 1255820..1256809 /gene="ykfD" /locus_tag="BSU_13000" /old_locus_tag="BSU13000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15101989; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cell wall oligopeptide ABC transporter (ATP binding protein)" /protein_id="NP_389183.2" /db_xref="EnsemblGenomes-Gn:BSU13000" /db_xref="EnsemblGenomes-Tr:CAB13157" /db_xref="GOA:C0SP98" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13234" /db_xref="UniProtKB/Swiss-Prot:C0SP98" /translation="MRRLPLLEVSQLKMHFDAGKKRTVKAVDGVTFQIREGETFGLVG ESGCGKSTLGRVLMRLYQPTEGSVTYRGTNLHALSEKEQFAFNRKLQMIFQDPYASLN PRMTVREIILEPMEIHNLYNTHKARLLVVDELLEAVGLHPDFGSRYPHEFSGGQRQRI GIARALSLNPEFIVADEPISALDVSVQAQVVNLLKRLQKEKGLTFLFIAHDLSMVKHI SDRIGVMYLGHMMEITESGTLYREPLHPYTKALLSSIPIPDPELEDKRERILLKGELP SPVNPPSGCVFRTRCPEAMPECGESRPQLQEIEPGRFVACHLYRNAETKEKVR*" /label="ykfD CDS" gene 1255820..1256809 /gene="ykfD" /locus_tag="BSU_13000" /old_locus_tag="BSU13000" /label="ykfD gene" S_feature complement(1256103..1256830) /Source="Nicolas_S_feature" /locus_tag="new_1369127_1369854_c" /HighExp="Etha, S7, Gly, M40t90, C30, H2O2, M0t90, dia15, T1.0H, S8" /AntisenseName="ykfD" /AntisenseCor="-6.3474114158352593E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S464" downshifts 1256799 /Source="Nicolas_upshifts" /id="D708" /incds=0 /nref=1 /ntot=91 /MaxReadThrough="5.08319" /MaxDrop="3.1399" /score="-3.10371155" /energy="-13.9" /TU="U1047,U1048" /idTUdmin="U1048" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" S_feature 1256844..1258012 /Source="Nicolas_S_feature" /locus_tag="new_1369868_1371036" /HighExp="T3.30H, T4.0H, T3.0H, T5.0H, T2.30H, T2.0H, S1, M9-stat, T1.30H, HiOs" /AntisenseName="ykgB" /AntisenseCor="-0.33524952291190102" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S465" CDS complement(1256852..1257901) /gene="pgl" /locus_tag="BSU_13010" /old_locus_tag="BSU13010" /EC_number="3.1.1.31" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:22960854, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phosphogluconolactonase" /protein_id="NP_389184.1" /db_xref="EnsemblGenomes-Gn:BSU13010" /db_xref="EnsemblGenomes-Tr:CAB13158" /db_xref="GOA:O34499" /db_xref="InterPro:IPR011048" /db_xref="InterPro:IPR015943" /db_xref="InterPro:IPR019405" /db_xref="SubtiList:BG13236" /db_xref="UniProtKB/Swiss-Prot:O34499" /translation="MTKYIGYVGTYTKGGSEGIYSFELDTEKKALSEPKLAAKLGNPT YVATNKNNTILYSIEKADGQGGVAAYQIDKNSGELTFLNHQLIDGPSPCHVSVDDQNQ FVLTANYHSGKVHVFPVQEDGSLQSPVSEAAHTGKGPHERQEKPHTHYAGFTPEHNYV VAVDLGIDKLYTYKLKDGVLTESGSHSFAPGAGPRHIAFHPKEKYAYVMTELSNEVIA LEYNPTAGEFREIQVVSAIPDDFTDNSQGSAIHVTQDGRFVYVANRGHDSIAVFEVNQ YSGELAFVERVSTEGNWPRDFVFDPTEGFLVASNEETGNLVLFERDKETGRLTLLPST VSVPYPVCVKFLHQV*" /label="pgl CDS" gene complement(1256852..1257901) /gene="pgl" /locus_tag="BSU_13010" /old_locus_tag="BSU13010" /label="pgl gene" downshifts complement(1256875) /Source="Nicolas_upshifts" /id="D709" /incds=0 /nref=208 /ntot=262 /MaxReadThrough="5.12776" /MaxDrop="6.0668" /score="24.6986564" /energy="-15.6" /TU="U1050" /idTUdmin="U1049" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1257928..1257947) /Source="Nicolas_upshift_promotors" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1257939) /Source="Nicolas_upshifts" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1257962..1257969) /Source="Nicolas_upshift_promotors" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1257991..1258851) /gene="ddaH" /locus_tag="BSU_13020" /old_locus_tag="BSU13020" /EC_number="3.5.3.18" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27258038; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N(G),N(G)-dimethylarginine dimethylaminohydrolase" /protein_id="NP_389185.2" /db_xref="EnsemblGenomes-Gn:BSU13020" /db_xref="EnsemblGenomes-Tr:CAB13159" /db_xref="GOA:O34497" /db_xref="InterPro:IPR033199" /db_xref="SubtiList:BG13235" /db_xref="UniProtKB/Swiss-Prot:O34497" /translation="MDVSIPKSQHKTVCRTEYGTLQKVILCKPEHMTIKDVINETQKH FEDDNIHVKTANDQHSRLVEALRSHNVEVVLLPVRDGLPEQVFTRDIGFVIGEKAFLS SMTEPIRQGEEAVIKDFFHSQGISYTRMLDTSIEGGDVIIDDDIVYVGISQRTDISAI GQLEEALPEYTIVPVKLHEKFLHLDCVFNIISESEALIYSQAIEPDAADMLAKRYDLI EVPEDEQFTLGTNVLSIGKKTIISLPGNRHVNQQLSKRGYHIIEIDLSEIIKSGGSFR CCTMPLIRGE*" /label="ddaH CDS" gene complement(1257991..1258851) /gene="ddaH" /locus_tag="BSU_13020" /old_locus_tag="BSU13020" /label="ddaH gene" promotor_-10 complement(1258876..1258894) /Source="Nicolas_upshift_promotors" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1258893) /Source="Nicolas_upshifts" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1258910..1258916) /Source="Nicolas_upshift_promotors" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1258925..1258932 /Source="Nicolas_upshift_promotors" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1258946..1258965 /Source="Nicolas_upshift_promotors" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1258953 /Source="Nicolas_upshifts" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="upshifts" CDS 1259011..1259529 /gene="ykhA" /locus_tag="BSU_13030" /old_locus_tag="BSU13030" /EC_number="3.1.2.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12426338, 18247525, 24623648, 24722906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous acyl-CoA thioesterase" /protein_id="NP_389186.2" /db_xref="EnsemblGenomes-Gn:BSU13030" /db_xref="EnsemblGenomes-Tr:CAB13160" /db_xref="GOA:P49851" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR033120" /db_xref="SubtiList:BG11417" /db_xref="UniProtKB/Swiss-Prot:P49851" /translation="METPETRFCKESKVVKTSRVFPLDTNNHNTLFGGKLMSYIDDIA SISAARHCRRETVTASMDSVDFLKPIGQKDSVCLESYVTWVGTSSMEVFVKVIKEHLM TGERELAATSFLTFVALDSNGKPVPVPRVVPETEEEIMLHNTAVQRANERKNRKRHSQ ALANALGTDKPW*" /label="ykhA CDS" gene 1259011..1259529 /gene="ykhA" /locus_tag="BSU_13030" /old_locus_tag="BSU13030" /label="ykhA gene" downshifts 1259520 /Source="Nicolas_upshifts" /id="D710" /incds=0 /nref=34 /ntot=265 /MaxReadThrough="4.66856" /MaxDrop="4.77681" /score="24.0889455" /energy="-10.9" /TU="U1051" /idTUdmin="U1051" /TUdmin="-1436" /isTUend="FALSE" /label="downshifts" promotor_-35 1259594..1259600 /Source="Nicolas_upshift_promotors" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="promotor_-35" S_feature 1259612..1259718 /Source="Nicolas_S_feature" /locus_tag="new_1372636_1372742" /HighExp="Etha, S5, S6, S8, nit, S7, ferm, S4, dia15, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S466" upshifts 1259612 /Source="Nicolas_upshifts" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="upshifts" promotor_-10 1259614..1259625 /Source="Nicolas_upshift_promotors" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="promotor_-10" promotor_-35 1259693..1259696 /Source="Nicolas_upshift_promotors" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1259712..1259731 /Source="Nicolas_upshift_promotors" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1259720 /Source="Nicolas_upshifts" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="upshifts" CDS 1259768..1260967 /gene="hmpA" /locus_tag="BSU_13040" /old_locus_tag="BSU13040" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10658656, 10972836, 12469342, 15231799, 15751990, 16261196, 16517672, 17293416, 24214949, 26786044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658656, 10972836, 12469342, 15231799, 15751990, 16261196, 16517672, 17293416, 24214949, 26786044; Product type c: carrier" /codon_start=1 /transl_table=11 /product="flavohemoglobin" /protein_id="NP_389187.1" /db_xref="EnsemblGenomes-Gn:BSU13040" /db_xref="EnsemblGenomes-Tr:CAB13161" /db_xref="GOA:P49852" /db_xref="InterPro:IPR000971" /db_xref="InterPro:IPR001221" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR008333" /db_xref="InterPro:IPR009050" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR023950" /db_xref="SubtiList:BG11418" /db_xref="UniProtKB/Swiss-Prot:P49852" /translation="MLDNKTIEIIKSTVPVLQQHGETITGRFYDRMFQDHPELLNIFN QTNQKKKTQRTALANAVIAAAANIDQLGNIIPVVKQIGHKHRSIGIKPEHYPIVGKYL LIAIKDVLGDAATPDIMQAWEKAYGVIADAFIGIEKDMYEQAEEQAGGWKEYKPFVIA KKERESKEITSFYLKPEDSKPLPEFQAGQYISIKVRIPDSEYTHIRQYSLSDMPGKDY YRISVKKDGVVSSYLHDGLQEGDSIEISAPAGDFVLDHASQKDLVLISAGVGITPMIS MLKTSVSKQPERQILFIHAAKNSEYHALRHEVEEAAKHSAVKTAFVYREPTEEDRAGD LHFHEGQIDQQFLKELIANTDADYYICGSPSFITAMHKLVSELGSAPESIHYELFGPQ LSLAQSV*" /label="hmpA CDS" gene 1259768..1260967 /gene="hmpA" /locus_tag="BSU_13040" /old_locus_tag="BSU13040" /label="hmpA gene" downshifts 1260956 /Source="Nicolas_upshifts" /id="D711" /incds=0 /nref=10 /ntot=59 /MaxReadThrough="6.06442" /MaxDrop="4.19301" /score="11.2868967" /energy="-9.3" /TU="U1053" /idTUdmin="U1051" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1261001..1261372 /Source="Nicolas_S_feature" /locus_tag="new_1374025_1374396" /HighExp="nit, B36, B60, Etha, BI, M40t90, LBGtran, M0t90, BT, S6" /AntisenseName="ykzH" /AntisenseCor="7.6554747052539299E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="SigGF" /TUlongPSig="0.998" /label="S467" CDS complement(1261044..1261268) /gene="ykzH" /locus_tag="BSU_13050" /old_locus_tag="BSU13050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389188.1" /db_xref="EnsemblGenomes-Gn:BSU13050" /db_xref="EnsemblGenomes-Tr:CAB13162" /db_xref="SubtiList:BG13336" /db_xref="UniProtKB/Swiss-Prot:O31653" /translation="MKNQKSNTLWPFDLPLAPQPEGYQQQTIDRLAGLELRMKQLIRA IEVNNELLRTMQEQQNRVCTNGSGSVIVRM*" /label="ykzH CDS" gene complement(1261044..1261268) /gene="ykzH" /locus_tag="BSU_13050" /old_locus_tag="BSU13050" /label="ykzH gene" promotor_-35 1261348..1261354 /Source="Nicolas_upshift_promotors" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1261368..1261379 /Source="Nicolas_upshift_promotors" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1261374 /Source="Nicolas_upshifts" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="upshifts" CDS 1261413..1262144 /gene="ykjA" /locus_tag="BSU_13060" /old_locus_tag="BSU13060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_389189.1" /db_xref="EnsemblGenomes-Gn:BSU13060" /db_xref="EnsemblGenomes-Tr:CAB13163" /db_xref="GOA:P49853" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG11419" /db_xref="UniProtKB/Swiss-Prot:P49853" /translation="MLWMVWVFLLKPVIVFSIAYILFRLAGKKAVSQMNNFDLLLTFA IGTIISEPILTSKLPMSIYYAGAFLVLYLIMSKLSLSNKWRWLLVVSPTVLIRNGDID ERGLRKERLTVNELLGKLREKGYADPADIDLAIIEETGEVSVIPKEEARAVQVRDLNM EAERNFIPIPLILDGEILDHNLKYLQKNRSWLFEKLEEKGYSPKLLSSIILGTMNARG DISLDLNTANEPQHDPYLYKPGNNN*" /label="ykjA CDS" gene 1261413..1262144 /gene="ykjA" /locus_tag="BSU_13060" /old_locus_tag="BSU13060" /label="ykjA gene" downshifts 1262122 /Source="Nicolas_upshifts" /id="D712" /incds=0 /nref=14 /ntot=29 /MaxReadThrough="2.84532" /MaxDrop="4.44655" /score="17.2468985" /energy="-7.2" /TU="U1053" /idTUdmin="U1054" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1262183..1262191 /Source="Nicolas_upshift_promotors" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1262202..1262220 /Source="Nicolas_upshift_promotors" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1262210 /Source="Nicolas_upshifts" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="upshifts" CDS 1262236..1262763 /gene="ykkA" /locus_tag="BSU_13070" /old_locus_tag="BSU13070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389190.1" /db_xref="EnsemblGenomes-Gn:BSU13070" /db_xref="EnsemblGenomes-Tr:CAB13164" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG11420" /db_xref="UniProtKB/Swiss-Prot:P49854" /translation="MKDLSIRNDMAPTVSLLYSAVEENSLRLASIVSHMTHSELYYKG RCQTKNSTAQLLHHITNVDIRWVWRIKENRIPDHIEQAYGPMTDESGRLPEPVNQPDL DELLKRHQHVVEKLKSVCFTLTENALNQPLSFEGDTATIRWGIWHMADHNRYHQAHIE ALKKEWKQDVAKYER*" /label="ykkA CDS" gene 1262236..1262763 /gene="ykkA" /locus_tag="BSU_13070" /old_locus_tag="BSU13070" /label="ykkA gene" CDS 1262753..1263271 /gene="ykkB" /locus_tag="BSU_13080" /old_locus_tag="BSU13080" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_389191.1" /db_xref="EnsemblGenomes-Gn:BSU13080" /db_xref="EnsemblGenomes-Tr:CAB13165" /db_xref="GOA:P49855" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11421" /db_xref="UniProtKB/Swiss-Prot:P49855" /translation="MNAKTKLVTDRIRLRCMEDRDQATLFGLLFNDPDVMTYYSGLKD KRQTREWVNWNQRNEKGYGVSLWIAEDKRTGEFLGQCGIVPQQIENQTVMEIGYMFAR RHWGNGYAQEAARACLDYGFNERQFGKMAALIDPGNKASIRVAEKIGMHYSKTIRKWN KPIAVYERKSYN*" /label="ykkB CDS" gene 1262753..1263271 /gene="ykkB" /locus_tag="BSU_13080" /old_locus_tag="BSU13080" /label="ykkB gene" promotor_-35 1263265..1263272 /Source="Nicolas_upshift_promotors" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="promotor_-35" promotor_-10 1263286..1263305 /Source="Nicolas_upshift_promotors" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="promotor_-10" upshifts 1263289 /Source="Nicolas_upshifts" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="upshifts" misc_RNA 1263304..1263415 /gene="gdwA" /locus_tag="BSU_misc_RNA_16" /product="guanidine-sensing riboswitch (binds free guanidinium)" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17908319, 21317561, 27989440, 28001368, 28017522, 28107646, 28212758; Product type n: RNA" /label="gdwA RNA" gene 1263304..1263415 /gene="gdwA" /locus_tag="BSU_misc_RNA_16" /label="gdwA gene" downshifts 1263378 /Source="Nicolas_upshifts" /id="D713" /incds=0 /nref=205 /ntot=246 /MaxReadThrough="3.70824" /MaxDrop="6.58389" /score="30.3456563" /energy="-18.5" /TU="U1056" /idTUdmin="U1056" /TUdmin="-789" /isTUend="FALSE" /label="downshifts" CDS 1263493..1263831 /gene="gdnC" /locus_tag="BSU_13090" /old_locus_tag="BSU13090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735877, 10931887, 15096624, 28001372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735877, 10931887, 15096624, 28001372; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanidinium efflux transporter subunit" /protein_id="NP_389192.1" /db_xref="EnsemblGenomes-Gn:BSU13090" /db_xref="EnsemblGenomes-Tr:CAB13166" /db_xref="GOA:P49856" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG11422" /db_xref="UniProtKB/Swiss-Prot:P49856" /translation="MKWGLVVLAAVFEVVWVIGLKHADSALTWSGTAIGIIFSFYLLM KATHSLPVGTVYAVFTGLGTAGTVLSEIVLFHEPVGWPKLLLIGVLLIGVIGLKLVTQ DETEEKGGEA*" /label="gdnC CDS" gene 1263493..1263831 /gene="gdnC" /locus_tag="BSU_13090" /old_locus_tag="BSU13090" /label="gdnC gene" CDS 1263831..1264148 /gene="gdnD" /locus_tag="BSU_13100" /old_locus_tag="BSU13100" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735877, 10931887, 15096624, 28001372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735877, 10931887, 15096624, 28001372; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanidinium efflux transporter subunit" /protein_id="NP_389193.1" /db_xref="EnsemblGenomes-Gn:BSU13100" /db_xref="EnsemblGenomes-Tr:CAB13167" /db_xref="GOA:P49857" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG11423" /db_xref="UniProtKB/Swiss-Prot:P49857" /translation="MLHWISLLCAGCLEMAGVALMNQYAKEKSVKWVLLIIVGFAASF SLLSYAMETTPMGTAYAVWTGIGTAGGALIGILFYKEQKDAKRIFFIALILCSAVGLK ILS*" /label="gdnD CDS" gene 1263831..1264148 /gene="gdnD" /locus_tag="BSU_13100" /old_locus_tag="BSU13100" /label="gdnD gene" promotor_-35 1264148..1264151 /Source="Nicolas_upshift_promotors" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1264167..1264186 /Source="Nicolas_upshift_promotors" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1264179 /Source="Nicolas_upshifts" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="upshifts" CDS 1264219..1265121 /gene="purU" /locus_tag="BSU_13110" /old_locus_tag="BSU13110" /EC_number="3.5.1.10" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8226647, 24108189; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formyltetrahydrofolate hydrolase" /protein_id="NP_389194.2" /db_xref="EnsemblGenomes-Gn:BSU13110" /db_xref="EnsemblGenomes-Tr:CAB13168" /db_xref="GOA:O34990" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004810" /db_xref="InterPro:IPR036477" /db_xref="SubtiList:BG13237" /db_xref="UniProtKB/Swiss-Prot:O34990" /translation="MKSYMTQRLDEYRDGNEDKGRLLVSCPDQPGIVSAVSAFLFEHG ANIIESNQYTTDPEGGRFFLRIEFDCAGIREKKSSLQAAFASVAEKFDMTWSLTLASE LKRVAIFVSKELHCLHELIWEWQTGNLMAEIAVVISNHEEARELVERLNIPFHYMKAN KDIRAEVEKKQLELLEQYDVDVIVLARYMQILTPDFVSAHPNRIINIHHSFLPAFIGA NPYKRAYERGVKLIGATSHYVTNDLDEGPIIEQDIERVDHRDNAEALKNIGRTIERSV LARAVKWHLEDRVIVHENKTIVFN*" /label="purU CDS" gene 1264219..1265121 /gene="purU" /locus_tag="BSU_13110" /old_locus_tag="BSU13110" /label="purU gene" downshifts 1265112 /Source="Nicolas_upshifts" /id="D714" /incds=0 /nref=91 /ntot=226 /MaxReadThrough="3.55628" /MaxDrop="5.02155" /score="16.8011006" /energy="-13.1" /TU="U1057" /idTUdmin="U1056" /TUdmin=945 /isTUend="FALSE" /label="downshifts" promotor_-35 1265168..1265174 /Source="Nicolas_upshift_promotors" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1265180 /Source="Nicolas_upshifts" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1265188..1265207 /Source="Nicolas_upshift_promotors" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 1265209..1265419 /gene="pswB" /locus_tag="BSU_misc_RNA_17" /product="T-box riboswitch specific of proline tRNA" /experiment="publication(s) with functional evidences, PMID:11917026, 12749771, 19932103, 21233158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11917026, 12749771, 19932103, 21233158; Product type n: RNA" /function="16.3: Control" /label="pswB RNA" gene 1265209..1265419 /gene="pswB" /locus_tag="BSU_misc_RNA_17" /label="pswB gene" downshifts 1265377 /Source="Nicolas_upshifts" /id="D715" /incds=0 /nref=4 /ntot=52 /MaxReadThrough="6.91996" /MaxDrop="3.8361" /score="29.5878921" /energy="-17.6" /TU="U1057,U1058" /idTUdmin="U1056" /TUdmin=1210 /isTUend="FALSE" /label="downshifts" CDS 1265472..1266569 /gene="proB" /locus_tag="BSU_13120" /old_locus_tag="BSU13120" /EC_number="2.7.2.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16958849, 8083159, 21233158, 21784929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16958849, 8083159, 21233158, 21784929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate 5-kinase" /protein_id="NP_389195.2" /db_xref="EnsemblGenomes-Gn:BSU13120" /db_xref="EnsemblGenomes-Tr:CAB13169" /db_xref="GOA:P39820" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR005715" /db_xref="InterPro:IPR011529" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019797" /db_xref="InterPro:IPR036393" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG10963" /db_xref="UniProtKB/Swiss-Prot:P39820" /translation="MKKQRIVVKIGSSSLTNSKGSIDEAKIREHVQAISVLKKAGHEM ILITSGAVAAGFSSLGYPSRPVTIKGKQAAAAVGQTLLMQQYMNQFKQYSLTPGQILL TRNDFSKRERYRNAYATIMELLERGVIPIINENDSTSVEELTFGDNDMLSALVSGLIH ADQLMILTDINGLYDANPNENPEAKRFDYLPEITPELLGYAGSAGSKVGTGGMKSKLL ATQTALSLGVKVFIGTGSGEQKLADILDGRGDGTYIGDKELSSVNNTRQWIQFHSPIS GEIIIDAGAEEAMIHNGSSLLPAGVVGVNGSFPKGAVVEVRGPGGVIGKGQTHYSSEE IMEAKGKRSDELDFEKTFEVIHRNDWVNVKD*" /label="proB CDS" gene 1265472..1266569 /gene="proB" /locus_tag="BSU_13120" /old_locus_tag="BSU13120" /label="proB gene" promotor_-35 1265659..1265661 /Source="Nicolas_upshift_promotors" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1265663..1265667 /Source="Nicolas_upshift_promotors" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1265663 /Source="Nicolas_upshifts" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="upshifts" CDS 1266581..1267828 /gene="proA" /locus_tag="BSU_13130" /old_locus_tag="BSU13130" /EC_number="1.2.1.41" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16958849, 8083159, 21784929, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16958849, 8083159, 21784929, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gamma-glutamyl phosphate reductase" /protein_id="NP_389196.2" /db_xref="EnsemblGenomes-Gn:BSU13130" /db_xref="EnsemblGenomes-Tr:CAB13170" /db_xref="GOA:P39821" /db_xref="InterPro:IPR000965" /db_xref="InterPro:IPR012134" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR020593" /db_xref="SubtiList:BG10964" /db_xref="UniProtKB/Swiss-Prot:P39821" /translation="MSEVSVKAKLAKEAAAEMIMKTTAEKDEALSLIANGLRKELDFL LAENAKDIVNGKENGLTPDIIDRLSLDEKRIRDIADAVELLIDLADPIGDSLETIEKE NGLFIEKIRVPLGVVGMIYEARPNVTVDAATLCLKTGNAVVLRGSSSAIHSNKALVSV IYRALEQSALPIHAVQLIEDTSRETAKELFTLNDGLDVLIPRGGKKLIDLVVRESTVP VLETGAGNCHIFIDETAKPQMAEKVVVNAKTQRPSVCNAIESLLIHKAWARQHGKELL DQLENAGVEIRGDELVCELHPSSKQASKEDWETEFLAPVLSVKTVENVQEAVKHIQQY GTNHSEAILTENDKNAVYFQTAVDAAAVYHNASTRFTDGFEFGYGAEIGISTQKLHAR GPMGLPALTSTKYIIKGTGQIRE*" /label="proA CDS" gene 1266581..1267828 /gene="proA" /locus_tag="BSU_13130" /old_locus_tag="BSU13130" /label="proA gene" downshifts 1267819 /Source="Nicolas_upshifts" /id="D716" /incds=0 /nref=120 /ntot=228 /MaxReadThrough="4.1607" /MaxDrop="6.017" /score="11.118012" /energy="-11" /TU="U1058" /idTUdmin="U1059" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1267890..1267897 /Source="Nicolas_upshift_promotors" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1267912..1267931 /Source="Nicolas_upshift_promotors" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1267921 /Source="Nicolas_upshifts" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="upshifts" CDS 1267954..1268379 /gene="ohrA" /locus_tag="BSU_13140" /old_locus_tag="BSU13140" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11418552, 17502599, 21749987, 24184231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418552, 17502599, 21749987, 24184231; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxiredoxin" /protein_id="NP_389197.1" /db_xref="EnsemblGenomes-Gn:BSU13140" /db_xref="EnsemblGenomes-Tr:CAB13171" /db_xref="GOA:O34762" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019953" /db_xref="InterPro:IPR036102" /db_xref="SubtiList:BG13238" /db_xref="UniProtKB/Swiss-Prot:O34762" /translation="MSQPLFTATVSAVGGREGKVISSDRVLELDVAMPGTPRAKKLEK ATNPEQLFAAGYAACFDSALQLVARTERVKVETEVTANVSLLKDEADQGYKLGVTLQV KGEGVSASELEALVKKAHGVCPYSKATSGNIDVTLEVAE*" /label="ohrA CDS" gene 1267954..1268379 /gene="ohrA" /locus_tag="BSU_13140" /old_locus_tag="BSU13140" /label="ohrA gene" downshifts 1268368 /Source="Nicolas_upshifts" /id="D717" /incds=0 /nref=57 /ntot=174 /MaxReadThrough="0.0429100000000009" /MaxDrop="3.90314" /score="30.9245751" /energy="-16.6" /TU="NA" /idTUdmin="U1060" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1268410..1268853) /gene="ohrR" /locus_tag="BSU_13150" /old_locus_tag="BSU13150" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11983871, 17502599, 18363800, 20094649, 21749987, 24184231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11983871, 17502599, 18363800, 20094649, 21749987, 24184231; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator sensing organic peroxides" /protein_id="NP_389198.1" /db_xref="EnsemblGenomes-Gn:BSU13150" /db_xref="EnsemblGenomes-Tr:CAB13172" /db_xref="GOA:O34777" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1Z91" /db_xref="PDB:1Z9C" /db_xref="SubtiList:BG13239" /db_xref="UniProtKB/Swiss-Prot:O34777" /translation="MENKFDHMKLENQLCFLLYASSREMTKQYKPLLDKLNITYPQYL ALLLLWEHETLTVKKMGEQLYLDSGTLTPMLKRMEQQGLITRKRSEEDERSVLISLTE DGALLKEKAVDIPGTILGLSKQSGEDLKQLKSALYTLLETLHQKN*" /label="ohrR CDS" gene complement(1268410..1268853) /gene="ohrR" /locus_tag="BSU_13150" /old_locus_tag="BSU13150" /label="ohrR gene" downshifts complement(1268444) /Source="Nicolas_upshifts" /id="D718" /incds=0 /nref=105 /ntot=232 /MaxReadThrough="-0.17111" /MaxDrop="4.73026" /score="34.7008532" /energy="-16.6" /TU="NA" /idTUdmin="U1061" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1268880..1268899) /Source="Nicolas_upshift_promotors" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1268886) /Source="Nicolas_upshifts" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1268914..1268917) /Source="Nicolas_upshift_promotors" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1268935..1268941 /Source="Nicolas_upshift_promotors" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1268955..1268973 /Source="Nicolas_upshift_promotors" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1268961 /Source="Nicolas_upshifts" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="upshifts" CDS 1268996..1269406 /gene="ohrB" /locus_tag="BSU_13160" /old_locus_tag="BSU13160" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9696771, 11418552, 18084074" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696771, 11418552, 18084074; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="organic hydroperoxide resistance reductase B" /protein_id="NP_389199.1" /db_xref="EnsemblGenomes-Gn:BSU13160" /db_xref="EnsemblGenomes-Tr:CAB13173" /db_xref="GOA:P80242" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019953" /db_xref="InterPro:IPR036102" /db_xref="PDB:2BJO" /db_xref="SubtiList:BG19021" /db_xref="UniProtKB/Swiss-Prot:P80242" /translation="MALFTAKVTARGGRAGHITSDDGVLDFDIVMPNAKKEGQTGTNP EQLFAAGYAACFGGALEHVAKEQNIEIDSEIEGQVSLMKDESDGGFKIGVTLVVNTKD LDREKAQELVNAAHEFCPYSKATRGNVDVKLELK*" /label="ohrB CDS" gene 1268996..1269406 /gene="ohrB" /locus_tag="BSU_13160" /old_locus_tag="BSU13160" /label="ohrB gene" downshifts 1269384 /Source="Nicolas_upshifts" /id="D719" /incds=0 /nref=7 /ntot=145 /MaxReadThrough="8.17185" /MaxDrop="4.0663" /score="17.6512157" /energy="-12.1" /TU="U1062" /idTUdmin="U1062" /TUdmin="-855" /isTUend="FALSE" /label="downshifts" CDS 1269433..1269603 /gene="ykzN" /locus_tag="BSU_13169" /old_locus_tag="BSU13169" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097717.1" /db_xref="EnsemblGenomes-Gn:BSU13169" /db_xref="EnsemblGenomes-Tr:CAX52607" /db_xref="UniProtKB/Swiss-Prot:C0H400" /translation="MFFGVGHAGRAQIYDKTSEKRLKHAFKPKVTDEAGGWHGVCRAE LRVYAVLYLHRA*" /label="ykzN CDS" gene 1269433..1269603 /gene="ykzN" /locus_tag="BSU_13169" /old_locus_tag="BSU13169" /label="ykzN gene" S_feature 1269604..1270281 /Source="Nicolas_S_feature" /locus_tag="new_1382628_1383305" /HighExp="Etha, Salt, M9-stat, Sw, B60, LPhT, B36, Heat, Gly, BC" /AntisenseName="guaD" /AntisenseCor="-5.7732597431508298E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S468" CDS complement(1269653..1270123) /gene="guaN" /locus_tag="BSU_13170" /old_locus_tag="BSU13170" /EC_number="3.5.4.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11101664, 15180998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11101664, 15180998; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="guanine deaminase" /protein_id="NP_389200.1" /db_xref="EnsemblGenomes-Gn:BSU13170" /db_xref="EnsemblGenomes-Tr:CAB13174" /db_xref="GOA:O34598" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="PDB:1TIY" /db_xref="PDB:1WKQ" /db_xref="SubtiList:BG13240" /db_xref="UniProtKB/Swiss-Prot:O34598" /translation="MNHETFLKRAVTLACEGVNAGIGGPFGAVIVKDGAIIAEGQNNV TTSNDPTAHAEVTAIRKACKVLGAYQLDDCILYTSCEPCPMCLGAIYWARPKAVFYAA EHTDAAEAGFDDSFIYKEIDKPAEERTIPFYQVTLTEHLSPFQAWRNFANKKEY*" /label="guaN CDS" gene complement(1269653..1270123) /gene="guaN" /locus_tag="BSU_13170" /old_locus_tag="BSU13170" /label="guaN gene" downshifts complement(1269677) /Source="Nicolas_upshifts" /id="D720" /incds=0 /nref=25 /ntot=112 /MaxReadThrough="0.698199999999999" /MaxDrop="4.30578" /score="-6.41557266" /energy="-13.5" /TU="NA" /idTUdmin="U1063" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1270145..1270164) /Source="Nicolas_upshift_promotors" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1270161) /Source="Nicolas_upshifts" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1270163..1270270) /Source="Nicolas_S_feature" /locus_tag="new_1383187_1383294_c" /HighExp="BMM, MG 10, MG 15, MG 5, MG t5, GM 25, B36, Gly, B60, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.044, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S469" promotor_-35 complement(1270180..1270183) /Source="Nicolas_upshift_promotors" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1270239 /Source="Nicolas_upshifts" /id="D721" /incds=0 /nref=9 /ntot=34 /MaxReadThrough="0.95942" /MaxDrop="5.95076" /score="15.2916843" /energy="-11.5" /TU="NA" /idTUdmin="U1062" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1270296..1272584) /gene="metE" /locus_tag="BSU_13180" /old_locus_tag="BSU13180" /EC_number="2.1.1.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8755891, 10094622, 12910260, 16086852, 16194229, 17012790, 17611193, 21749987, 22938038, 24313874" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755891, 10094622, 12910260, 16086852, 16194229, 17012790, 17611193, 21749987, 22938038, 24313874; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cobalamin-independent methionine synthase" /protein_id="NP_389201.2" /db_xref="EnsemblGenomes-Gn:BSU13180" /db_xref="EnsemblGenomes-Tr:CAB13175" /db_xref="GOA:P80877" /db_xref="InterPro:IPR002629" /db_xref="InterPro:IPR006276" /db_xref="InterPro:IPR013215" /db_xref="SubtiList:BG12616" /db_xref="UniProtKB/Swiss-Prot:P80877" /translation="MTTIKTSNLGFPRIGLNREWKKALEAYWKGSTDKDTFLKQIDEL FLSAVKTQIDQQIDVVPVSDFTQYDHVLDTAVSFNWIPKRFRHLTDATDTYFAIARGI KDAVSSEMTKWFNTNYHYIVPEYDESIEFRLTRNKQLEDYRRIKQEYGVETKPVIVGP YTFVTLAKGYEPSEAKAIQKRLVPLYVQLLKELEEEGVKWVQIDEPALVTASSEDVRG AKELFESITSELSSLNVLLQTYFDSVDAYEELISYPVQGIGLDFVHDKGRNLEQLKTH GFPTDKVLAAGVIDGRNIWKADLEERLDAVLDILSIAKVDELWIQPSSSLLHVPVAKH PDEHLEKDLLNGLSYAKEKLAELTALKEGLVSGKAAISEEIQQAKADIQALKQFATGA NSEQKKELEQLTDKDFKRPIPFEERLALQNESLGLPLLPTTTIGSFPQSAEVRSARQK WRKAEWSDEQYQNFINAETKRWIDIQEELELDVLVHGEFERTDMVEYFGEKLAGFAFT KYAWVQSYGSRCVRPPVIYGDVEFIEPMTVKDTVYAQSLTSKHVKGMLTGPVTILNWS FPRNDISRKEIAFQIGLALRKEVKALEDAGIQIIQVDEPALREGLPLKTRDWDEYLTW AAEAFRLTTSSVKNETQIHTHMCYSNFEDIVDTINDLDADVITIEHSRSHGGFLDYLK NHPYLKGLGLGVYDIHSPRVPSTEEMYNIIVDALAVCPTDRFWVNPDCGLKTRQQEET VAALKNMVEAAKQARAQQTQLV*" /label="metE CDS" gene complement(1270296..1272584) /gene="metE" /locus_tag="BSU_13180" /old_locus_tag="BSU13180" /label="metE gene" downshifts complement(1270315) /Source="Nicolas_upshifts" /id="D722" /incds=0 /nref=212 /ntot=239 /MaxReadThrough="5.25958" /MaxDrop="7.50935" /score="29.3354648" /energy="-11.5" /TU="U1064,U1065" /idTUdmin="U1063" /TUdmin="-638" /isTUend="FALSE" /label="downshifts" S_feature complement(1272585..1272647) /Source="Nicolas_S_feature" /locus_tag="new_1385609_1385671_c" /HighExp="MG 15, MG 5, MG t5, BMM, T-1.40H, MG 25, MG 10, GM 25, Mal, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.044, 1, 0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S470" promotor_no_box complement(1272607..1272707) /Source="Nicolas_upshift_promotors" /id="U1064" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.332667332667333" /psig="0.043956043956044" /xcortree=3023 /SigmaFactorBS="agtgttttacgtagaaaagcctctttctctcatgggaaagag gctttttgttgtgagaaaacctcttagcagcctgtatccgcgggtgaaagagagtgtt t" /listShort="S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1272647) /Source="Nicolas_upshifts" /id="U1064" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.332667332667333" /psig="0.043956043956044" /xcortree=3023 /SigmaFactorBS="agtgttttacgtagaaaagcctctttctctcatgggaaagag gctttttgttgtgagaaaacctcttagcagcctgtatccgcgggtgaaagagagtgtt t" /listShort="S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="upshifts" misc_RNA complement(1272712..1272867) /gene="mswB" /locus_tag="BSU_misc_RNA_18" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762, 22543867" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762, 22543867; Product type n : RNA" /function="16.3: Control" /label="mswB RNA" gene complement(1272712..1272867) /gene="mswB" /locus_tag="BSU_misc_RNA_18" /label="mswB gene" downshifts complement(1272713) /Source="Nicolas_upshifts" /id="D723" /incds=0 /nref=55 /ntot=106 /MaxReadThrough="8.12248" /MaxDrop="6.4813" /score="24.0596293" /energy="-16.2" /TU="U1065,U1066" /idTUdmin="U1066" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1272900..1272919) /Source="Nicolas_upshift_promotors" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1272912) /Source="Nicolas_upshifts" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1272914..1272999) /Source="Nicolas_S_feature" /locus_tag="new_1385938_1386023_c" /HighExp="BT, BC, B36, M9-stat, T5.0H, S3, S6, T4.0H, S5, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S471" promotor_-35 complement(1272935..1272942) /Source="Nicolas_upshift_promotors" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1273000..1273959) /gene="ispA" /locus_tag="BSU_13190" /old_locus_tag="BSU13190" /EC_number="3.4.21.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3087947, 14680823, 23569278" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3087947, 14680823, 23569278; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="intracellular serine protease" /protein_id="NP_389202.1" /db_xref="EnsemblGenomes-Gn:BSU13190" /db_xref="EnsemblGenomes-Tr:CAB13176" /db_xref="GOA:P11018" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034202" /db_xref="InterPro:IPR036852" /db_xref="SubtiList:BG10674" /db_xref="UniProtKB/Swiss-Prot:P11018" /translation="MNGEIRLIPYVTNEQIMDVNELPEGIKVIKAPEMWAKGVKGKNI KVAVLDTGCDTSHPDLKNQIIGGKNFTDDDGGKEDAISDYNGHGTHVAGTIAANDSNG GIAGVAPEASLLIVKVLGGENGSGQYEWIINGINYAVEQKVDIISMSLGGPSDVPELK EAVKNAVKNGVLVVCAAGNEGDGDERTEELSYPAAYNEVIAVGSVSVARELSEFSNAN KEIDLVAPGENILSTLPNKKYGKLTGTSMAAPHVSGALALIKSYEEESFQRKLSESEV FAQLIRRTLPLDIAKTLAGNGFLYLTAPDELAEKAEQSHLLTL*" /label="ispA CDS" gene complement(1273000..1273959) /gene="ispA" /locus_tag="BSU_13190" /old_locus_tag="BSU13190" /label="ispA gene" S_feature complement(1273960..1274011) /Source="Nicolas_S_feature" /locus_tag="new_1386984_1387035_c" /HighExp="BT, B36, BC, T5.0H, M9-stat, T0.30H, T3.30H, T3.0H, T4.0H, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S472" promotor_-10 complement(1274004..1274023) /Source="Nicolas_upshift_promotors" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1274016) /Source="Nicolas_upshifts" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1274037..1274043) /Source="Nicolas_upshift_promotors" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1274128..1274131 /Source="Nicolas_upshift_promotors" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1274144 /Source="Nicolas_upshifts" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1274147..1274166 /Source="Nicolas_upshift_promotors" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1274182..1275015 /gene="rsbRB" /locus_tag="BSU_13200" /old_locus_tag="BSU13200" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 17158665" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 17158665; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome)" /protein_id="NP_389203.1" /db_xref="EnsemblGenomes-Gn:BSU13200" /db_xref="EnsemblGenomes-Tr:CAB13177" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG12609" /db_xref="UniProtKB/Swiss-Prot:O34860" /translation="MKLNEKLYAFFSEHVEQMAEEWIETMEESDPNSLYALHNATVTE ELKEQDREFYRHLNYMYVLPEKQFLEEFQEWVIELTNDQKHLDTPVQYVIREFMRNRR LYTKYFEKFAEENESAFEPGEKQKWADLIVKVFDFTIYTFVDHAEMNAKQQLNAQREM ILELSSPVITLSKSTALLPLVGDIDTERAKFILENTLQACAKRRVEHLLIDLSGVVVV DTMVAHQIFKLIEALNLIGVRSTLSGIRPEIAQTAVQLGIDFSNITIKTNLAQALNYH Q*" /label="rsbRB CDS" gene 1274182..1275015 /gene="rsbRB" /locus_tag="BSU_13200" /old_locus_tag="BSU13200" /label="rsbRB gene" downshifts 1274991 /Source="Nicolas_upshifts" /id="D724" /incds=0 /nref=219 /ntot=254 /MaxReadThrough="3.01586" /MaxDrop="6.07238" /score="22.2655638" /energy="-12.1" /TU="NA" /idTUdmin="U1067" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1275046..1275810) /gene="thiX" /locus_tag="BSU_13210" /old_locus_tag="BSU13210" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 18931129" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 18931129; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine transporter, transmembrane T component" /protein_id="NP_389204.1" /db_xref="EnsemblGenomes-Gn:BSU13210" /db_xref="EnsemblGenomes-Tr:CAB13178" /db_xref="GOA:O34572" /db_xref="InterPro:IPR003339" /db_xref="SubtiList:BG13248" /db_xref="UniProtKB/Swiss-Prot:O34572" /translation="MKQPLHLINPTVKAAAVFCCVVMLSFIYNPYTPACFYIIIVAGV LLAAGIPLKKWLLFTIPFLILAFGCVWTAAVFGKVPTTPDNFLFQAGPISINSDNVSV GISLGFRILCFSALSMMFVFTTDPILFMLSLVQQCRLSPKLAYGVIAGFRFLPLLKDE VQLIQQAHKIRGGAAESGIINKISALKRYTIPLLASAIRKAERTALAMESKGFTGSRN RTYYRTLSVNRRDWVFFCLVLLLFAGSFLVSLCFAS*" /label="thiX CDS" gene complement(1275046..1275810) /gene="thiX" /locus_tag="BSU_13210" /old_locus_tag="BSU13210" /label="thiX gene" downshifts complement(1275067) /Source="Nicolas_upshifts" /id="D725" /incds=0 /nref=143 /ntot=164 /MaxReadThrough="0.824010000000001" /MaxDrop="6.67697" /score="34.7739353" /energy="-12.1" /TU="NA" /idTUdmin="U1069" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1275785..1277428) /gene="thiW" /locus_tag="BSU_13220" /old_locus_tag="BSU13220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 18931129" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 18931129; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine ABC transporter (ATP-binding subunit)" /protein_id="NP_389205.2" /db_xref="EnsemblGenomes-Gn:BSU13220" /db_xref="EnsemblGenomes-Tr:CAB13179" /db_xref="GOA:O34362" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13249" /db_xref="UniProtKB/Swiss-Prot:O34362" /translation="MQAFDELLTVEQLSFSYEEDEKPVFQDISFELQKGECVLLLGPS GCGKSSLALCLNGLYPEACDGIQSGHVFLFQKPVTDAETSETITQHAGVVFQDPDQQF CMLTVEDEIAFGLENLQIPKEEMTEKINAVLEKLRITHLKEKMISTLSGGQKQKVALA CILAMEPELIILDEPTSLLDPFSAREFVHLMKDLQREKGFSLLVIEHQLDEWAPWIER TIVLDKSGKKALDGLTKNLFQHEAETLKKLGIAIPKVCHLQEKLSMPFTLSKEMLFKE PIPAGHVKKKKAPSGESVLEVSSLSFARGQQAIFKDISFSLREGSLTALVGPNGTGKS TLLSVLASLMKPQSGKILLYDQPLQKYKEKELRKRMGFVFQNPEHQFVTDTVYDELLF GQKANAETEKKAQHLLQRFGLAHLADHHPFAISQGQKRRLSVATMLMHDVKVLLLDEP TFGQDARTAAECMEMIQRIKAEGTAVLMITHDMELVSSYADSVLVLHDTGLAFDGSPA QLFSQETGLVQKAKLTLPLLYEWMAFQEEVRDEATVTSH*" /label="thiW CDS" gene complement(1275785..1277428) /gene="thiW" /locus_tag="BSU_13220" /old_locus_tag="BSU13220" /label="thiW gene" CDS complement(1277415..1278014) /gene="thiV" /locus_tag="BSU_13230" /old_locus_tag="BSU13230" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 27447050, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 27447050, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine transporter, permease component" /protein_id="NP_389206.2" /db_xref="EnsemblGenomes-Gn:BSU13230" /db_xref="EnsemblGenomes-Tr:CAB13180" /db_xref="GOA:O34738" /db_xref="InterPro:IPR017195" /db_xref="PDB:5EDL" /db_xref="SubtiList:BG13250" /db_xref="UniProtKB/Swiss-Prot:O34738" /translation="MKSWKVKEIVIMSVISIVFAVVYLLFTHFGNVLAGMFGPIAYEP IYGIWFIVSVIAAYMIRKPGAALVSEIIAALVECLLGNPSGPMVIVIGIVQGLGAEAV FLATRWKAYSLPVLMLAGMGSSVASFIYDLFVSGYAAYSPGYLLIMLVIRLISGALLA GLLGKAVSDSLAYTGVLNGMALGKELKKKRKRASEHASL*" /label="thiV CDS" gene complement(1277415..1278014) /gene="thiV" /locus_tag="BSU_13230" /old_locus_tag="BSU13230" /label="thiV gene" CDS complement(1278016..1278618) /gene="thiU" /locus_tag="BSU_13240" /old_locus_tag="BSU13240" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15451668, 16291685, 16356850, 20471400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15451668, 16291685, 16356850, 20471400; Product type f: factor" /codon_start=1 /transl_table=11 /product="thiamine-binding protein (oxidation stress protein)" /protein_id="NP_389207.1" /db_xref="EnsemblGenomes-Gn:BSU13240" /db_xref="EnsemblGenomes-Tr:CAB13181" /db_xref="GOA:O34911" /db_xref="InterPro:IPR011522" /db_xref="InterPro:IPR015835" /db_xref="InterPro:IPR029756" /db_xref="PDB:1S7H" /db_xref="PDB:1S99" /db_xref="PDB:1SBR" /db_xref="SubtiList:BG13251" /db_xref="UniProtKB/Swiss-Prot:O34911" /translation="MEHICGTSRIAGFRFSLYPMTDDFISVIKSALKKTDTSKVWTKT DHISTVLRGSIDHVFDAAKAIYLHAANSEQHIVMNGTFSIGCPGDTQGDTYLSKGDKR VNEDAVRGLKAEAPCQFALYPMNEPDYMGLIMEAVDIAKAQGTFVQGVHYASELDGDA HDVFSTLEAVFRMAEQQTNHITMTVNLSANSPSRKNRKQG*" /label="thiU CDS" gene complement(1278016..1278618) /gene="thiU" /locus_tag="BSU_13240" /old_locus_tag="BSU13240" /label="thiU gene" downshifts complement(1278696) /Source="Nicolas_upshifts" /id="D726" /incds=0 /nref=28 /ntot=88 /MaxReadThrough="7.47395" /MaxDrop="5.73297" /score="19.7469386" /energy="-10.9" /TU="U1069" /idTUdmin="U1069" /TUdmin="-3629" /isTUend="FALSE" /label="downshifts" misc_RNA complement(1278715..1278827) /gene="tswB" /locus_tag="BSU_misc_RNA_19" /product="thiamine pyrophosphate riboswitch" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswB RNA" gene complement(1278715..1278827) /gene="tswB" /locus_tag="BSU_misc_RNA_19" /label="tswB gene" promotor_-35 1278828..1278831 /Source="Nicolas_upshift_promotors" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1278842..1278861) /Source="Nicolas_upshift_promotors" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1278847..1278866 /Source="Nicolas_upshift_promotors" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1278858 /Source="Nicolas_upshifts" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1278863) /Source="Nicolas_upshifts" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1278876..1278883) /Source="Nicolas_upshift_promotors" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1278929..1279615 /gene="ykoG" /locus_tag="BSU_13250" /old_locus_tag="BSU13250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YkoH]" /protein_id="NP_389208.1" /db_xref="EnsemblGenomes-Gn:BSU13250" /db_xref="EnsemblGenomes-Tr:CAB13182" /db_xref="GOA:O34903" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13252" /db_xref="UniProtKB/Swiss-Prot:O34903" /translation="MEKGHILIVEDEEKIARVLQLELEYEGYSVTIKHNGTEGLDAAA EGGYSLVLLDVMLPGLSGLEVLRRLRKTDSQTPVILLTARDSIPDKVTGLDIGANDYV TKPFEIEELLARIRAALRQNGTKTEDIGTFLTYDDLRVNEKTREVRRGDKEVELTPRE FDLLVYMLKHPQQVLTREQILSSVWGFDYIGDTNVVDVYIRYIRKKLDYPYEKQLIHT IRGVGYAIKG*" /label="ykoG CDS" gene 1278929..1279615 /gene="ykoG" /locus_tag="BSU_13250" /old_locus_tag="BSU13250" /label="ykoG gene" CDS 1279619..1280983 /gene="ykoH" /locus_tag="BSU_13260" /old_locus_tag="BSU13260" /EC_number="2.7.13.3" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YkoG]" /protein_id="NP_389209.1" /db_xref="EnsemblGenomes-Gn:BSU13260" /db_xref="EnsemblGenomes-Tr:CAB13183" /db_xref="GOA:O34638" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13253" /db_xref="UniProtKB/Swiss-Prot:O34638" /translation="MKLKTKIHLYTSISLLILLILVHTAVYLIFSSALTSKDAARLAD ETDNIAEALRAAETEGVALQDMLQAYLPANGMVRVVNGDQKAVMTITKEKAYKDFPLS FHSGETADVRKPDGKLFAEAAVPVIWTDGQVVSLQLVERLENTEESLFLLKIILIAAS AAVCIASFFAGSLLARRIINPIRRLMITMKDIQRDKEFKTISLEGQSNDELYQMGLTF NEMAMMLKEHYDKQQQFVQDASHELKTPLTIIESYSSLMKRWGAKKPEVLEESIEAIH SEAVHMKKLTNQLLALAKSHQGLEVDLKTIDLIKAARAVMQTLQSVYQRDILLETDKE SLLVKADEERIKQLLTILLDNAIKYSEKPIEMSAGTRNGRPFLSVRDEGIGIPEEHIP HLFERFYRADEARNRKTGGTGLGLSIAKQIADEHGIELSVKSKPGQGTAVTMQFSEQN GGGR*" /label="ykoH CDS" gene 1279619..1280983 /gene="ykoH" /locus_tag="BSU_13260" /old_locus_tag="BSU13260" /label="ykoH gene" CDS 1280980..1281660 /gene="ykoI" /locus_tag="BSU_13270" /old_locus_tag="BSU13270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717295; Product type m : membranecomponent" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_389210.1" /db_xref="EnsemblGenomes-Gn:BSU13270" /db_xref="EnsemblGenomes-Tr:CAB13184" /db_xref="GOA:O34551" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13254" /db_xref="UniProtKB/Swiss-Prot:O34551" /translation="MTKTIKTVSFAAAAILVVIICTFLIIRQTHENVLSKETVVKKVE ASYEGKVTKATQSKDKKTYDITLENPKGTYFVKADAISADILSMNRVKAVNPSAMTEK EAEHLALERVPGTVKKQTRQSQVATYTIQKEDGKTYEVKVDMQAKTVLSADQISSKDQ QKTPITKKEAKTIAERKTGGTADDADLEESEGTLIFEVDVDLPDNKEATVKINAYTGK VANIVYED*" /label="ykoI CDS" gene 1280980..1281660 /gene="ykoI" /locus_tag="BSU_13270" /old_locus_tag="BSU13270" /label="ykoI gene" promotor_-35 1281689..1281694 /Source="Nicolas_upshift_promotors" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1281710..1281728 /Source="Nicolas_upshift_promotors" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1281713 /Source="Nicolas_upshifts" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="upshifts" CDS 1281752..1282264 /gene="ykoJ" /locus_tag="BSU_13280" /old_locus_tag="BSU13280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17209068; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389211.1" /db_xref="EnsemblGenomes-Gn:BSU13280" /db_xref="EnsemblGenomes-Tr:CAB13185" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13255" /db_xref="UniProtKB/Swiss-Prot:O35012" /translation="MLKKKWMVGLLAGCLAAGGFSYNAFATENNENRQASSKTDALTE QEAEAIAKTVVDGTVEDIDRDLYNGKEVYEVEIEKEGEDYDVYVDIHTKQALNDPLKE KAEQVAITKEEAEEIALKQTGGTVTESKLDEDDGAYIYEMEIQTKQGTETEFEISAKD GRIIKQEIDD*" /label="ykoJ CDS" gene 1281752..1282264 /gene="ykoJ" /locus_tag="BSU_13280" /old_locus_tag="BSU13280" /label="ykoJ gene" downshifts 1282250 /Source="Nicolas_upshifts" /id="D727" /incds=0 /nref=52 /ntot=228 /MaxReadThrough="3.74302" /MaxDrop="6.03059" /score="28.1760649" /energy="-13.7" /TU="U1070" /idTUdmin="U1070" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" promotor_-35 1282295..1282301 /Source="Nicolas_upshift_promotors" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1282315..1282326 /Source="Nicolas_upshift_promotors" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1282316 /Source="Nicolas_upshifts" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="upshifts" CDS 1282347..1282484 /gene="ykzD" /locus_tag="BSU_13290" /old_locus_tag="BSU13290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389212.1" /db_xref="EnsemblGenomes-Gn:BSU13290" /db_xref="EnsemblGenomes-Tr:CAB13186" /db_xref="InterPro:IPR022608" /db_xref="SubtiList:BG13332" /db_xref="UniProtKB/Swiss-Prot:O34405" /translation="MEKKEEQYINQAEYVPHPTKEGEYALFLHETYHLLSEDDETQTT E*" /label="ykzD CDS" gene 1282347..1282484 /gene="ykzD" /locus_tag="BSU_13290" /old_locus_tag="BSU13290" /label="ykzD gene" downshifts 1282457 /Source="Nicolas_upshifts" /id="D728" /incds=0 /nref=7 /ntot=31 /MaxReadThrough="1.81189" /MaxDrop="3.56977" /score="-4.52149284" /energy="-5.9" /TU="NA" /idTUdmin="U1070" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 1282543..1282550 /Source="Nicolas_upshift_promotors" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1282564..1282583 /Source="Nicolas_upshift_promotors" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1282566..1282885 /Source="Nicolas_S_feature" /locus_tag="new_1395590_1395909" /HighExp="LBGstat, LBGtran, M40t45, MG 25, Mt0, Salt, MG 45, LPhT, BMM, MG t5" /AntisenseName="ykzO" /AntisenseCor="-0.16301119751811899" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S473" upshifts 1282566 /Source="Nicolas_upshifts" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1282598..1282751 /gene="swmG" /locus_tag="BSU_misc_RNA_68" /product="magnesium riboswitch" /experiment="publication(s) with functional evidences, PMID:15096624, 17803910, 21315082, 28455443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 17803910, 21315082, 28455443; Product type n: RNA" /function="16.12: Sense" /function="16.3: Control" /label="swmG RNA" gene 1282598..1282751 /gene="swmG" /locus_tag="BSU_misc_RNA_68" /label="swmG gene" promotor_-35 1282863..1282872 /Source="Nicolas_upshift_promotors" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1282885..1282904 /Source="Nicolas_upshift_promotors" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1282887..1282988 /Source="Nicolas_S_feature" /locus_tag="new_1395911_1396012" /HighExp="LBGstat, LBGtran, M40t45, Mt0, LPhT, Paraq, MG t5, MG 25, MG 60, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99773400000000001" /TUshortSig="SigK, SigA" /TUshortPSig="0.876, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S474" upshifts 1282887 /Source="Nicolas_upshifts" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="upshifts" CDS 1282989..1284344 /gene="mgtE" /locus_tag="BSU_13300" /old_locus_tag="BSU13300" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15096624, 22970223, 24415722, 24968120, 25182490" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 22970223, 24415722, 24968120, 25182490; Product type t : transporter" /codon_start=1 /transl_table=11 /product="magnesium transporter" /protein_id="NP_389213.1" /db_xref="EnsemblGenomes-Gn:BSU13300" /db_xref="EnsemblGenomes-Tr:CAB13187" /db_xref="GOA:O34442" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR006667" /db_xref="InterPro:IPR006668" /db_xref="InterPro:IPR006669" /db_xref="InterPro:IPR036739" /db_xref="SubtiList:BG13256" /db_xref="UniProtKB/Swiss-Prot:O34442" /translation="MVQNMTYDELILRIIILLRDGKIRDFRSVIDELQPYDMAFIFKE MPEKHRARYLSYLTVDDITDMIGELEREFQLVVLNKVGKTKATLAMNKMDNDDLAQLL EEMDEELKEQLLSSMEASESKAVQLLMNYPADSAGRMMTNRYVWIPQHYTVKDAVVKL KSFAEIAESINYLYVINESKQLVGVLSYRDLILGEPEEKVQDLMFTRVISADALQDQE EVARLIERYDFLAIPVVEENNVLVGIVTVDDIIDVVIREADEDYEKFAASGKDITFDT KAYVAAYRRLPWLILLLFIGLISGSIISYFEDALKQVVALAFFMPMVSGMTGNTGTQS LAVVIRGLSKEEMNKKTIVRLIFREFRTSIFIGAVCSVLIAIVSIIWQGNALLGFVVA SSLFLTLIIGTMSGTIIPIILHKLKVDPAIASGPLITTLNDILSLLIYFGIATAFIHS L*" /label="mgtE CDS" gene 1282989..1284344 /gene="mgtE" /locus_tag="BSU_13300" /old_locus_tag="BSU13300" /label="mgtE gene" downshifts 1284335 /Source="Nicolas_upshifts" /id="D729" /incds=0 /nref=160 /ntot=239 /MaxReadThrough="1.02063" /MaxDrop="7.38933" /score="-4.14569718" /energy="-8.9" /TU="NA" /idTUdmin="U1072" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1284387..1284719) /gene="tnrA" /locus_tag="BSU_13310" /old_locus_tag="BSU13310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10231480, 12823818, 15916606, 16547045, 17085574, 17183219, 21435182, 23535029, 26635369" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10231480, 12823818, 15916606, 16547045, 17085574, 17183219, 21435182, 23535029, 26635369; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nitrogen sensing transcriptional regulator" /protein_id="NP_389214.1" /db_xref="EnsemblGenomes-Gn:BSU13310" /db_xref="EnsemblGenomes-Tr:CAB13188" /db_xref="GOA:Q45666" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="PDB:4S0R" /db_xref="SubtiList:BG11805" /db_xref="UniProtKB/Swiss-Prot:Q45666" /translation="MTTEDHSYKDKKVISIGIVSELTGLSVRQIRYYEERKLIYPQRS SRGTRKYSFADVERLMDIANKREDGVQTAEILKDMRKKEQMLKNDPQVRKKMLEGQLN AHFRYKNR*" /label="tnrA CDS" gene complement(1284387..1284719) /gene="tnrA" /locus_tag="BSU_13310" /old_locus_tag="BSU13310" /label="tnrA gene" promotor_-10 complement(1284735..1284754) /Source="Nicolas_upshift_promotors" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1284745) /Source="Nicolas_upshifts" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1284747..1285135) /Source="Nicolas_S_feature" /locus_tag="new_1397771_1398159_c" /HighExp="M9-stat, BC, LoTm, T1.30H, T0.30H, T2.0H, S8, C30, T4.0H, T2.30H" /AntisenseName="ykzB" /AntisenseCor="-3.3870578787867499E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.92" /TUlongSig="NA" /TUlongPSig="NA" /label="S475" promotor_-35 complement(1284770..1284775) /Source="Nicolas_upshift_promotors" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 1284807..1284907 /Source="Nicolas_upshift_promotors" /id="U1075" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.295704295704296" /xcortree=315 /SigmaFactorBS="agaagatttttgaaaaaatacggaagaaaaattaacaagaat aatgcgtaacacccaagcgcgttttatcctttatgtaacgaatcaaacgaggaggaag g" /listShort="ykzB, ykoL" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1284867 /Source="Nicolas_upshifts" /id="U1075" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.295704295704296" /xcortree=315 /SigmaFactorBS="agaagatttttgaaaaaatacggaagaaaaattaacaagaat aatgcgtaacacccaagcgcgttttatcctttatgtaacgaatcaaacgaggaggaag g" /listShort="ykzB, ykoL" /GFF_Attribute="listLong" /label="upshifts" CDS 1284914..1285069 /gene="ykzB" /locus_tag="BSU_13320" /old_locus_tag="BSU13320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10671441" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389215.1" /db_xref="EnsemblGenomes-Gn:BSU13320" /db_xref="EnsemblGenomes-Tr:CAB13189" /db_xref="SubtiList:BG13330" /db_xref="UniProtKB/Swiss-Prot:O34923" /translation="MEEEKAVSLAKEIIELDIKRDEMLETFMQLAGEQAFQLLRSVQN GQYRKSS*" /label="ykzB CDS" gene 1284914..1285069 /gene="ykzB" /locus_tag="BSU_13320" /old_locus_tag="BSU13320" /label="ykzB gene" promotor_-35 1285078..1285085 /Source="Nicolas_upshift_promotors" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1285092..1285109 /Source="Nicolas_upshift_promotors" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1285109 /Source="Nicolas_upshifts" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1285120..1285139) /Source="Nicolas_upshift_promotors" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1285135) /Source="Nicolas_upshifts" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1285153..1285159) /Source="Nicolas_upshift_promotors" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1285157..1285339 /gene="ykoL" /locus_tag="BSU_13330" /old_locus_tag="BSU13330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10671441" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389216.1" /db_xref="EnsemblGenomes-Gn:BSU13330" /db_xref="EnsemblGenomes-Tr:CAB13190" /db_xref="SubtiList:BG13257" /db_xref="UniProtKB/Swiss-Prot:O34763" /translation="MSNLLKSALEKERRHYSEKLYQIGVYNKEVMNKMTISELRKEYA YFFRSITNHKNYPYTR*" /label="ykoL CDS" gene 1285157..1285339 /gene="ykoL" /locus_tag="BSU_13330" /old_locus_tag="BSU13330" /label="ykoL gene" downshifts 1285307 /Source="Nicolas_upshifts" /id="D730" /incds=0 /nref=2 /ntot=8 /MaxReadThrough="3.83398" /MaxDrop="4.6651" /score="19.6832496" /energy="-11.2" /TU="U1076" /idTUdmin="U1075" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1285364..1285372 /Source="Nicolas_upshift_promotors" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1285383..1285401 /Source="Nicolas_upshift_promotors" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1285389..1285471 /Source="Nicolas_S_feature" /locus_tag="new_1398413_1398495" /HighExp="T3.0H, M9-stat, T1.30H, T2.30H, Lbstat, T3.30H, Lbtran, S2, T4.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, Sig-" /TUshortPSig="0.996, 0.00699" /TUlongSig="NA" /TUlongPSig="NA" /label="S476" upshifts 1285389 /Source="Nicolas_upshifts" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="upshifts" CDS 1285472..1285936 /gene="ykoM" /locus_tag="BSU_13340" /old_locus_tag="BSU13340" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_389217.1" /db_xref="EnsemblGenomes-Gn:BSU13340" /db_xref="EnsemblGenomes-Tr:CAB13191" /db_xref="GOA:O34949" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13258" /db_xref="UniProtKB/Swiss-Prot:O34949" /translation="MMRLSFNEEEVERAMNLYRVFARAFKSVSEHSIRDSKEHGFNPT EFAVLELLYTRGPQKLQQIGSRLLLVSGNVTYVIDKLERNGFLVREQDPKDKRSVYAH LTDKGNEYLDKIYPIHALRIARAFSGLSPDEQDQLIVLLKKAGIHSQHLLFR*" /label="ykoM CDS" gene 1285472..1285936 /gene="ykoM" /locus_tag="BSU_13340" /old_locus_tag="BSU13340" /label="ykoM gene" downshifts 1285921 /Source="Nicolas_upshifts" /id="D731" /incds=0 /nref=70 /ntot=210 /MaxReadThrough="2.86787" /MaxDrop="5.38705" /score="24.8730632" /energy="-9.8" /TU="U1078" /idTUdmin="U1078" /TUdmin="-112" /isTUend="FALSE" /label="downshifts" CDS complement(1285951..1287072) /gene="ykoN" /locus_tag="BSU_13350" /old_locus_tag="BSU13350" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389218.2" /db_xref="EnsemblGenomes-Gn:BSU13350" /db_xref="EnsemblGenomes-Tr:CAB13192" /db_xref="GOA:C0SPB9" /db_xref="InterPro:IPR009695" /db_xref="SubtiList:BG13259" /db_xref="UniProtKB/Swiss-Prot:C0SPB9" /translation="MKNILIFPFLSISTGHHHVADALQAELESQGLAAEKIDIFSHSY RRLEKLSSVAYLKWIQYFPKTYSGIYRLLACGEFQHDKRYFMYEWLFTQQMRHILQEK QPDIAFCTHALPSYLLNRLKPEYPNLTVVNVYTDFFVNQLWGRKNIDYHFVPSTEVKK QLISEGIDQNNIYLTGIPVHQNFEMESADTLQHHPPYTIIITGGSMGVGGILKWVQEL SPGGKILYKILCGRNEKLYSYVKSLHHPLIEAIPYLHSKAEMNRLYEQATGIMTKPGG VTISECLQKRLPVFIYHALPGQEEMNLNLLHERKLVTDMRNWDMQKAEEYIAAFFQSN EQMKEYKKHVNGYLGEMSDRKIKDVLKRIIWKQKNTLLK*" /label="ykoN CDS" gene complement(1285951..1287072) /gene="ykoN" /locus_tag="BSU_13350" /old_locus_tag="BSU13350" /label="ykoN gene" promotor_-35 1286360..1286368 /Source="Nicolas_upshift_promotors" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1286382..1286401 /Source="Nicolas_upshift_promotors" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1286385..1287163 /Source="Nicolas_S_feature" /locus_tag="new_1399409_1400187" /HighExp="S6, S8, S7, S5, BT, B36, S4, S3, Pyr, G/S" /AntisenseName="ykoN" /AntisenseCor="0.84084970563549499" /AntisenseRegPval="-72.400000000000006" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.979" /TUlongSig="NA" /TUlongPSig="NA" /label="S477" upshifts 1286385 /Source="Nicolas_upshifts" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1287101..1287112) /Source="Nicolas_upshift_promotors" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1287121) /Source="Nicolas_upshifts" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1287127..1287133) /Source="Nicolas_upshift_promotors" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1287164..1287715 /gene="ykoP" /locus_tag="BSU_13360" /old_locus_tag="BSU13360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389219.2" /db_xref="EnsemblGenomes-Gn:BSU13360" /db_xref="EnsemblGenomes-Tr:CAB13193" /db_xref="SubtiList:BG13260" /db_xref="UniProtKB/Swiss-Prot:O34495" /translation="MKTCFLSIWRVVDPIYFFFSRLSLIDNDQKSVFRVRLTKYKGHH VVLSDGTHIRKNDVLVKIHLHNIKLIRELQSIESAVRKGIIIYQKVYQSMPLLLDYIN NHKKSEKIKGIIGITMLDKGVERLGFDVITPVNPFYRCFKKVSHVPILYLTSKPVSLR HLPNSSYLFISKEKLQKTYQKKD*" /label="ykoP CDS" gene 1287164..1287715 /gene="ykoP" /locus_tag="BSU_13360" /old_locus_tag="BSU13360" /label="ykoP gene" downshifts 1287683 /Source="Nicolas_upshifts" /id="D732" /incds=0 /nref=4 /ntot=25 /MaxReadThrough="3.31887" /MaxDrop="3.7149" /score="-2.92393792" /energy="-7" /TU="U1079" /idTUdmin="U1079" /TUdmin="-242" /isTUend="FALSE" /label="downshifts" CDS complement(1287743..1288555) /gene="ykoQ" /locus_tag="BSU_13370" /old_locus_tag="BSU13370" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metallophosphoesterase" /protein_id="NP_389220.1" /db_xref="EnsemblGenomes-Gn:BSU13370" /db_xref="EnsemblGenomes-Tr:CAB13194" /db_xref="GOA:O35040" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13261" /db_xref="UniProtKB/Swiss-Prot:O35040" /translation="MFTILLSLAILVFVPFLYKANRNTKDVKVNTISIDQKDGLPARK KLNILHLSDLHLENISVSPEELYHLTKDQPVDIIALTGDFLDRKRNIPKLAGYLNALQ KLKPAYGMYAVFGNHDYVLKEEDFQRLKRVLEENGCITLQNEHVRIETAAGPVNIIGI DDYSTNRSNITGSYQSLENGYHLVLTHDPNIILDMKDVHYDYLLSGHFHGGQIHWPKP YHLVKMGKLVRMNMIKGLHYHHDKPFYISEGLGQTGVNIRVGSRPEVTFHQI*" /label="ykoQ CDS" gene complement(1287743..1288555) /gene="ykoQ" /locus_tag="BSU_13370" /old_locus_tag="BSU13370" /label="ykoQ gene" promotor_-10 complement(1288515..1288534) /Source="Nicolas_upshift_promotors" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1288529) /Source="Nicolas_upshifts" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1288548..1288553) /Source="Nicolas_upshift_promotors" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1288656..1288662 /Source="Nicolas_upshift_promotors" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1288673..1288747 /Source="Nicolas_S_feature" /locus_tag="new_1401697_1401771" /HighExp="S5, S6, S7, S4, S8, T5.0H, ferm, nit, S3, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S478" upshifts 1288673 /Source="Nicolas_upshifts" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1288676..1288687 /Source="Nicolas_upshift_promotors" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1288748..1290442 /gene="ykoS" /locus_tag="BSU_13380" /old_locus_tag="BSU13380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_389221.1" /db_xref="EnsemblGenomes-Gn:BSU13380" /db_xref="EnsemblGenomes-Tr:CAB13195" /db_xref="GOA:O34830" /db_xref="SubtiList:BG13262" /db_xref="UniProtKB/Swiss-Prot:O34830" /translation="MLRLMRQQKKETYYLWIALFLLLLYVSPLFILKEDAHIRVHDNL DSNIAWYKVLADSGEIVGKVDAAIPQIINGLPRDAFGTEWSGIVWLHAFFSSMTAYAI SQTVTRVVAFFGMYVLLKKHIIPEPKAAFIRIGVSLAFALTPFWPSGMLSTLGYPLAL WAFLNIRKGDISWREWLTLGLLPLYSSFVLGFFFFLAGMACFWLYDAITKRRWNLMFL GSIAFMTSIYLFVEYRLVYSMLFEHAPMHRIEFISSRHDVWHSLRLSIKNFVYGHNHV MTVHTVVILPILMVVFAALLFKRNRTKPENVYLFLCVLNYGLSLWYAFWFNKIWAVPK QKFAFLAEFNFARFHFLRPLVIYVSFALALYLIWRMGKGWKWLVYAAVAAQLMVLAPF NEEYTYGVHYNAPTFREFYASEQFKEIKEYIGRPQDSYRVASIGLHPSIAQYNGFYTL DTYNNLYPLSYKYEFRKIIEKELEKNSRLKQYFDEWGSRCYLFVDELGKRYDFKKNSK KTINNLQLNTDVFKKMGGRYIFSSVPIMNAEQNHLALVKTFDHKDSAWRIYLYETR*" /label="ykoS CDS" gene 1288748..1290442 /gene="ykoS" /locus_tag="BSU_13380" /old_locus_tag="BSU13380" /label="ykoS gene" CDS 1290455..1291468 /gene="ykoT" /locus_tag="BSU_13390" /old_locus_tag="BSU13390" /EC_number="2.-.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389222.1" /db_xref="EnsemblGenomes-Gn:BSU13390" /db_xref="EnsemblGenomes-Tr:CAB13196" /db_xref="GOA:O34755" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13263" /db_xref="UniProtKB/Swiss-Prot:O34755" /translation="MKQSQPVLTIVVPCFNEEEVFQETSHQLTEVVDDLIEEKLIAED SKILFVDDGSKDRTWALIAMESIRNKKVTGLKLACNVGHQKALLAGLHKAKNRSDCVI SIDADLQDDISVIRDFMLKYHEGCEIVYGVRRSRKTDTFFKRTTALGFYRLMNKLGIK LIYNHADFRLMNKRSLEELERYPEANLFLRGIVPMIGFKSAEVLYDRKERFAGKTKYP LKKMLSFAFNGITSFSVAPIRFFTLLGFVLFFLSAVAGIGAFIQKLLGHTNAGWASLI ISIWFLGGLQLMGIGIIGEYIGTIFSEVKRRPKYAIDIDLYNEQLSPLQRQEKERLEK KYS*" /label="ykoT CDS" gene 1290455..1291468 /gene="ykoT" /locus_tag="BSU_13390" /old_locus_tag="BSU13390" /label="ykoT gene" downshifts 1291453 /Source="Nicolas_upshifts" /id="D733" /incds=0 /nref=13 /ntot=35 /MaxReadThrough="0.53349" /MaxDrop="4.80671" /score="19.4012674" /energy="-13.7" /TU="NA" /idTUdmin="U1082" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(1291494..1293329) /gene="ligD" /locus_tag="BSU_13400" /old_locus_tag="BSU13400" /EC_number="6.5.1.1" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12215643, 16497325, 17293412, 23691176, 25355514, 26826709" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12215643, 16497325, 17293412, 23691176, 25355514, 26826709; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA ligase subunit; 5'-2-deoxyribose-5-phosphate (dRP) lyase" /protein_id="NP_389223.1" /db_xref="EnsemblGenomes-Gn:BSU13400" /db_xref="EnsemblGenomes-Tr:CAB13197" /db_xref="GOA:O34398" /db_xref="InterPro:IPR012310" /db_xref="InterPro:IPR014143" /db_xref="InterPro:IPR014145" /db_xref="InterPro:IPR014146" /db_xref="InterPro:IPR033652" /db_xref="SubtiList:BG13264" /db_xref="UniProtKB/Swiss-Prot:O34398" /translation="MAFTMQPVLTSSPPIGAEWRYEVKYDGYRCILRIHSSGVTLTSR NGVELSSTFPEITQFAKTAFQHLEKELPLTLDGEIVCLVNPCRADFEHLQVRGRLKRP DKIQESANARPCCFLAFDLLERSGEDVTLLSYLDRKKSLRELISAAKLPASPDPYAKE TIQSIPCYDHFDQLWEMVIKYDGEGIVAKKTNSKWLEKKRSSDWLKYKNFKQAYVCIT GFNPNNGFLTVSVLKNGIMTPIASVSHGMRDEEKSAIREIMEQHGHQTPSGEFTLEPS ICAAVQYLTILQGTLREVSFIGFEFQMDWTECTYAQVIRHSKPVHPKLQFTSLDKIIF EKNKKTKEDFIQYMIEVSDYLLPFLKNRAVTVIRYPHGSRSESFFQKNKPDYAPDFVQ SFYDGSHEHIVCEDMSTLLWLCNQLALEFHVPFQTIKSRRPAEIVIDLDPPSRDDFLM AVQAANELKRLLDSFGITSYPKLSGNKGIQLYIPLSPEAFTYEETRQFTQLIAEYCTN AFPELFTTERLIKNRHCKLYLDYLQHAEGKTIICPYSTRGNELGTVAAPLYWHEVQSS LTPALFTIDTVIDRIKKQGCPFFDFYRNPQDEPLSAILHQLKKKS*" /label="ligD CDS" gene complement(1291494..1293329) /gene="ligD" /locus_tag="BSU_13400" /old_locus_tag="BSU13400" /label="ligD gene" downshifts complement(1291543) /Source="Nicolas_upshifts" /id="D734" /incds=0 /nref=10 /ntot=54 /MaxReadThrough="0.67916" /MaxDrop="5.08051" /score="-8.48510187" /energy="-13.7" /TU="NA" /idTUdmin="U1083" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1293333..1294268) /gene="ligV" /locus_tag="BSU_13410" /old_locus_tag="BSU13410" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11095673, 12215643, 16497325, 16780573, 23691176, 25355514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11095673, 12215643, 16497325, 16780573, 23691176, 25355514; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA ligase subunit Ku; AP/deoxyribose 5'-phosphate (5'-dRP)-lyase" /protein_id="NP_389224.1" /db_xref="EnsemblGenomes-Gn:BSU13410" /db_xref="EnsemblGenomes-Tr:CAB13198" /db_xref="GOA:O34859" /db_xref="InterPro:IPR006164" /db_xref="InterPro:IPR009187" /db_xref="InterPro:IPR016194" /db_xref="SubtiList:BG13265" /db_xref="UniProtKB/Swiss-Prot:O34859" /translation="MNRTPSLHTKEKKGFIDMHTMWKGSISFGLVNIPIKLYAATEDK DIKLRSLHKEDHAPIKYEKVCTNCEKTLSPDEIVKGYEYVKGKYVVLTDEDLKSLKQE HEEKAVEIVDFVQLQEIDPIYFNRSYFVGPGDNGTKAYTLLREALRSTGKIGIANMTI RSKQQLAILRVYENCIVMESIHYPDEVRSAAQVPGVPDQSNVNDKELQTAITLIDELT AKFEPEKYEDTYRQALLQRVNDKLENKETAVTPDKAPPREDVIDLVSALQASIDRTRR PNRETPAAAPAQAAEPKGAGDKKQKTTRKKASGTS*" /label="ligV CDS" gene complement(1293333..1294268) /gene="ligV" /locus_tag="BSU_13410" /old_locus_tag="BSU13410" /label="ligV gene" promotor_-10 complement(1294239..1294250) /Source="Nicolas_upshift_promotors" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1294249) /Source="Nicolas_upshifts" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1294265..1294271) /Source="Nicolas_upshift_promotors" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1294305..1296707) /gene="dgcW" /locus_tag="BSU_13420" /old_locus_tag="BSU13420" /EC_number="2.7.7.65" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11728710, 17010156, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11728710, 17010156, 23893111, 28536559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="YP_054577.2" /db_xref="EnsemblGenomes-Gn:BSU13420" /db_xref="EnsemblGenomes-Tr:CAB13199" /db_xref="GOA:O34311" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR005330" /db_xref="InterPro:IPR029787" /db_xref="InterPro:IPR035919" /db_xref="InterPro:IPR035965" /db_xref="SubtiList:BG13266" /db_xref="UniProtKB/Swiss-Prot:O34311" /translation="MEIHVTYNTTLICLSILIACTASYISLELSRKVTINTGLKSKIW LIGGSLIMGFGIWSMHFVGMMAVHMEMPMEYEFMPLMAAIGASVSGSFVSLYFVSRHI LTYYRLLTGSVVLGASIASMHYIGMSAISRVMIIYEPILFTVSIIIAIAASFVSLKIF FDLAVKKHSEHLIFYKGVSSIVMGIGISGMHYTGMLAATFHKDMAPPGSHMEVQTFHW SIFVTLIIFCIQTLLLFSSHADRKFIKQSERIKDNEQRFQSLIVHNIDAIFILSLEGD IISSNHAGEEMISKFGFSMHDWRNYTSLKVKRLFEQVKKDKQAMNSDSDLITEKGQFH LNITLIPVEVNQELDSIYVICKDMTKQYKAEKEIHRMAHYDSLTDLPNRRHAISHLTK VLNREHSLHYNTVVFFLDLNRFKVINDALGHNVGDQLLQFAAKRLSSVVPDNGFIARL GGDEFIIILTDANTGTGEADVLARKIIQKFKKPFKIQDHTLVTSVSIGIAISPKDGTD GLELMKKADMAMYAAKERNKSKYRYYSFSIGNKETVKLNQEMVLREAIENDRFVLHYQ PQFSVKKQKMTGAEALIRLVTPDGQLRPPGEFIGVAEETGLIIDIGKWIIDEACKQAR IWHDKGYDLSVAINISARQFQSKDLIPLIKDTLNKYQLPPQLLEVEVTESMTMDNLNH SKKVLSSLTELGIRISIDDFGTGHSSLSYLKDFPIHRLKIDKSFIDDIQTHPKSEQIT GAIIAMGHQLSLQVIAEGVENAAQKQLLFEKGCDHLQGFFFSRPIPPEQFEQFIIEQP SQ*" /label="dgcW CDS" gene complement(1294305..1296707) /gene="dgcW" /locus_tag="BSU_13420" /old_locus_tag="BSU13420" /label="dgcW gene" downshifts complement(1294337) /Source="Nicolas_upshifts" /id="D735" /incds=0 /nref=13 /ntot=101 /MaxReadThrough="1.93589" /MaxDrop="3.26543" /score="6.55794882" /energy="-9" /TU="NA" /idTUdmin="U1084" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1296555..1296757) /Source="Nicolas_S_feature" /locus_tag="new_1409579_1409781_c" /HighExp="Cold, GM 25, GM 10, GM 45, GM 15, GM-0.2, GM-0.1, GM 5, GM 90, Glu" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S479" promotor_-10 complement(1296746..1296764) /Source="Nicolas_upshift_promotors" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1296757) /Source="Nicolas_upshifts" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1296778..1296785) /Source="Nicolas_upshift_promotors" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1296824..1296831 /Source="Nicolas_upshift_promotors" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1296845..1296864 /Source="Nicolas_upshift_promotors" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1296857 /Source="Nicolas_upshifts" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="upshifts" CDS 1296888..1297553 /gene="ykoX" /locus_tag="BSU_13430" /old_locus_tag="BSU13430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23687963; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_389226.1" /db_xref="EnsemblGenomes-Gn:BSU13430" /db_xref="EnsemblGenomes-Tr:CAB13200" /db_xref="GOA:O34908" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13267" /db_xref="UniProtKB/Swiss-Prot:O34908" /translation="MIHKHETRELVAIEELVMSWIEAFKSLSYFGIFLALSIEFIPAE VVLPLAGYWVSKGDMTLAGVVLAGSLGGVAGPLTLYWIGRYGGRPFLERFGKYLFIKP EALDKSDNFFKKHGGFVAFSGRFLPGIRTLISIPCGIAKMNVWVFSLYTFIAMLPITF VYVYLGVKLGENWKAVGSILDQYMLPIGIAILALFLLYLLMKKRKKRTHSEQLSVFLK NKR*" /label="ykoX CDS" gene 1296888..1297553 /gene="ykoX" /locus_tag="BSU_13430" /old_locus_tag="BSU13430" /label="ykoX gene" promotor_-10 complement(1297422..1297441) /Source="Nicolas_upshift_promotors" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1297439) /Source="Nicolas_upshifts" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1297455..1297464) /Source="Nicolas_upshift_promotors" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1297548..1297555 /Source="Nicolas_upshift_promotors" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1297570..1297589 /Source="Nicolas_upshift_promotors" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1297583 /Source="Nicolas_upshifts" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1297609..1297742 /gene="mnrW" /locus_tag="BSU_misc_RNA_87" /product="manganese ion riboswitch" /experiment="publication(s) with functional evidences, PMID:25794618, 25794619" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25794618, 25794619; Product type n: RNA" /function="16.12: Sense" /function="16.3: Control" /label="mnrW RNA" gene 1297609..1297742 /gene="mnrW" /locus_tag="BSU_misc_RNA_87" /label="mnrW gene" CDS 1297630..1298604 /gene="ykoY" /locus_tag="BSU_13440" /old_locus_tag="BSU13440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15096624, 15849754, 16850406, 25794618, 25794619; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative manganese-related ion transporter" /protein_id="NP_389227.1" /db_xref="EnsemblGenomes-Gn:BSU13440" /db_xref="EnsemblGenomes-Tr:CAB13201" /db_xref="GOA:O34997" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022493" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13268" /db_xref="UniProtKB/Swiss-Prot:O34997" /translation="MYSGNKVVISWIVSIGFVGMPEFMSSKTFALCRQRSFLHGPAGI RSDEEKENNFFGRVSFMDAALLLEYGWVLLVLIGLEGILAADNALVMAVMVKHLPEEK RKKALFYGLAGAFVLRFGSLFAISFLVNVWQVQAIGAIYLLYISASHLLKRYVFKKED THKETKQSGFWPTVLKVELADIAFAVDSILAAVALAVTLPGTSLPKIGGLDGGQFLVI LAGGIIGLVIMRFAASMFVKLLKERPSLETAAFVIVGWVGVKLALYTLAHRDIAVVSE HFIHSGTWKLIFWGVLAAIAVCGWFMSGGKKQPEGAQNEQKNSTRERA*" /label="ykoY CDS" gene 1297630..1298604 /gene="ykoY" /locus_tag="BSU_13440" /old_locus_tag="BSU13440" /label="ykoY gene" downshifts 1297693 /Source="Nicolas_upshifts" /id="D736" /incds=1 /nref=38 /ntot=211 /MaxReadThrough="5.00041" /MaxDrop="4.46498" /score="15.8563987" /energy="-15" /TU="U1085,U1087" /idTUdmin="U1085" /TUdmin="-902" /isTUend="FALSE" /label="downshifts" downshifts 1298592 /Source="Nicolas_upshifts" /id="D737" /incds=0 /nref=16 /ntot=175 /MaxReadThrough="2.59801" /MaxDrop="4.20782" /score="24.4740487" /energy="-13.7" /TU="NA" /idTUdmin="U1085" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 1298714..1298722 /Source="Nicolas_upshift_promotors" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="promotor_-35" promotor_-10 1298736..1298744 /Source="Nicolas_upshift_promotors" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="promotor_-10" upshifts 1298746 /Source="Nicolas_upshifts" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="upshifts" S_feature 1298749..1298835 /Source="Nicolas_S_feature" /locus_tag="new_1411773_1411859" /HighExp="M9-stat, T1.30H, T1.0H, T0.30H, T2.0H, T2.30H, HiTm, M0t90, T3.0H, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29969800000000002" /TUshortSig="SigI" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S480" promotor_-35 1298808..1298815 /Source="Nicolas_upshift_promotors" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="promotor_-35" promotor_-10 1298829..1298848 /Source="Nicolas_upshift_promotors" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="promotor_-10" upshifts 1298837 /Source="Nicolas_upshifts" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="upshifts" CDS 1298868..1299623 /gene="sigI" /locus_tag="BSU_13450" /old_locus_tag="BSU13450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11157964, 12682299, 17185538, 18156261, 21541672, 24125693, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11157964, 12682299, 17185538, 18156261, 21541672, 24125693, 28333276; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma factor (heat stress responsive)" /protein_id="NP_389228.1" /db_xref="EnsemblGenomes-Gn:BSU13450" /db_xref="EnsemblGenomes-Tr:CAB13218" /db_xref="GOA:O31654" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014244" /db_xref="InterPro:IPR014284" /db_xref="SubtiList:BG13269" /db_xref="UniProtKB/Swiss-Prot:O31654" /translation="MKPVLSLLFKLGKKKQTLEKAVESIQKGNKDLQNELIQQYKPFI AKTVSSVCKRYIDEKDDEFSIGLIAFNEAIEKYSPEKGNSLLAFAELIIKRKVIDYIR KEARSAQNINIDLQEGDDQESSQSLIEAELSIDEYRRQIEQEQRREEILYFQKQLKDY GLSFKELLENSPKHTDARQNAIKVAMTLVEHEELAAILYTKKQLPVKQLEQLVSVSRK TIERNRKYIIAMCIIITGDYIYLKDYLKGVLHS*" /label="sigI CDS" gene 1298868..1299623 /gene="sigI" /locus_tag="BSU_13450" /old_locus_tag="BSU13450" /label="sigI gene" CDS 1299620..1300765 /gene="rsgI" /locus_tag="BSU_13460" /old_locus_tag="BSU13460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17185538, 23199363, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17185538, 23199363, 28333276; Product type f: factor" /codon_start=1 /transl_table=11 /product="sigmaI modulating factor" /protein_id="NP_389229.1" /db_xref="EnsemblGenomes-Gn:BSU13460" /db_xref="EnsemblGenomes-Tr:CAB13219" /db_xref="GOA:O31655" /db_xref="InterPro:IPR024449" /db_xref="SubtiList:BG13272" /db_xref="UniProtKB/Swiss-Prot:O31655" /translation="MRRGIIVEKNKKFVTLLTPDGQFLKAKNDRHSYEIGEEIMLPSE TRMGRRASFFDFFKLRPFKMGIFTMTAIMLFIFIVLPVFSNNKAYAYMTIDINPSVEM ALNSDYEVIELTPLNDEGQKVVNDIDDWEKTDFKKVIDDIITDCSEHGYVKKSKEILI STVYENTEDNTYKKAVKKQLNDVTEKYKTTYRMESLESDMQTREKAKKEGVSTGSYIK SNEKNDNKDIKDDSSKPSGEEDQKSDENEDENTDQTDTQDSKQGDNEQLNDADSGDQK EEKADDQIDDSDKDKKIKESDENTNTEKDGDHEQTPIQDPQDKGNENNGADKGQSQYH RDWNNGEQGKNRSSSRRDNASDRRNPNGYSSDNHSAKNEDSPSAPGE*" /label="rsgI CDS" gene 1299620..1300765 /gene="rsgI" /locus_tag="BSU_13460" /old_locus_tag="BSU13460" /label="rsgI gene" S_feature 1300766..1301925 /Source="Nicolas_S_feature" /locus_tag="new_1413790_1414949" /HighExp="HiTm, G135, G180, C30, G150, Cold, S8, MG 25, H2O2, Lbstat" /AntisenseName="ykrK" /AntisenseCor="0.122248209149143" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigI" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S481" CDS complement(1300776..1300970) /gene="sspD" /locus_tag="BSU_13470" /old_locus_tag="BSU13470" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:3009397, 3112127, 3121585, 9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3009397, 3112127, 3121585, 9852018; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha/beta-type SASP)" /protein_id="NP_389230.1" /db_xref="EnsemblGenomes-Gn:BSU13470" /db_xref="EnsemblGenomes-Tr:CAB13220" /db_xref="GOA:P04833" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10788" /db_xref="UniProtKB/Swiss-Prot:P04833" /translation="MASRNKLVVPGVEQALDQFKLEVAQEFGVNLGSDTVARANGSVG GEMTKRLVQQAQSQLNGTTK*" /label="sspD CDS" gene complement(1300776..1300970) /gene="sspD" /locus_tag="BSU_13470" /old_locus_tag="BSU13470" /label="sspD gene" downshifts complement(1300783) /Source="Nicolas_upshifts" /id="D738" /incds=0 /nref=24 /ntot=36 /MaxReadThrough="1.67859" /MaxDrop="4.68215" /score="41.3727153" /energy="-15.2" /TU="NA" /idTUdmin="U1090" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1301013..1301024) /Source="Nicolas_upshift_promotors" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1301023) /Source="Nicolas_upshifts" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1301039..1301045) /Source="Nicolas_upshift_promotors" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1301101..1301802) /gene="htpK" /locus_tag="BSU_13480" /old_locus_tag="BSU13480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22447908, 23042994" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22447908, 23042994; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of quality control" /protein_id="NP_389231.1" /db_xref="EnsemblGenomes-Gn:BSU13480" /db_xref="EnsemblGenomes-Tr:CAB13221" /db_xref="InterPro:IPR014975" /db_xref="SubtiList:BG13273" /db_xref="UniProtKB/Swiss-Prot:O31656" /translation="MNIFKLSRTDMVRLLYSLKGQGEHSPLDILVQSANMSAEKAANH LEIPEFLTRYERKKQKKEYGLSTNEIVELGNLCELTSLKSTAIQNWVKRDIKDLIGHP ELGKKYSIEQAVILLIVRDLKSIYDFEHIRAILKVAFNTISDRSDDVISPIAYYESCA YVLDAIHHQDTPSMKESNLQEIAEQETERLRHRFEELNDSQWLKIRQIIAITVLSILT FHIQATAHKMTADIL*" /label="htpK CDS" gene complement(1301101..1301802) /gene="htpK" /locus_tag="BSU_13480" /old_locus_tag="BSU13480" /label="htpK gene" downshifts complement(1301135) /Source="Nicolas_upshifts" /id="D739" /incds=0 /nref=174 /ntot=231 /MaxReadThrough="2.96889" /MaxDrop="5.30355" /score="41.3727153" /energy="-15.2" /TU="NA" /idTUdmin="U1091" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1301803..1301883) /Source="Nicolas_S_feature" /locus_tag="new_1414827_1414907_c" /HighExp="LBGtran, dia0, LBGexp, Lbexp, Oxctl, G180, M0t45, C90, Paraq, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S482" promotor_-10 complement(1301875..1301894) /Source="Nicolas_upshift_promotors" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1301883) /Source="Nicolas_upshifts" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1301899..1301906 /Source="Nicolas_upshift_promotors" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1301908..1301915) /Source="Nicolas_upshift_promotors" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1301920..1301939 /Source="Nicolas_upshift_promotors" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1301927 /Source="Nicolas_upshifts" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="upshifts" CDS 1301973..1302869 /gene="htpX" /locus_tag="BSU_13490" /old_locus_tag="BSU13490" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11860552, 12081643, 16076848, 16573693, 22447908, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="membrane protease" /protein_id="NP_389232.1" /db_xref="EnsemblGenomes-Gn:BSU13490" /db_xref="EnsemblGenomes-Tr:CAB13222" /db_xref="GOA:O31657" /db_xref="InterPro:IPR001915" /db_xref="InterPro:IPR022919" /db_xref="SubtiList:BG13274" /db_xref="UniProtKB/Swiss-Prot:O31657" /translation="MAKRIFLFILTNILVLTTIGIVLSVLSSVTGVGTYFTADGGIDP MALLVFSLVVGFVGSFTSLAISRWMAKTMMGVRVLNPKKHSLSYEEQQLVDRVHRLSR SAGLTKMPEVGIYRSPEVNAFATGPSKRRSLVAVSSGLLEQMDDAAVEGVLAHEVAHI TNGDMVTMTLLQGIVNTFVVFLSRIAAWIASRFVKEDLAPIVHFIAMIIFQIVFSILG SLVVFAYSRHREFHADRGGADLAGKDKMIHALRTLKSYSSRILEDDQTAVQTLKINGK KRSSLFSTHPDLDERIRRLEAK*" /label="htpX CDS" gene 1301973..1302869 /gene="htpX" /locus_tag="BSU_13490" /old_locus_tag="BSU13490" /label="htpX gene" downshifts 1302863 /Source="Nicolas_upshifts" /id="D740" /incds=0 /nref=203 /ntot=268 /MaxReadThrough="3.02778" /MaxDrop="6.27746" /score="38.5173589" /energy="-13.4" /TU="NA" /idTUdmin="U1092" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1302974..1302978 /Source="Nicolas_upshift_promotors" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1302994..1303013 /Source="Nicolas_upshift_promotors" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1302998 /Source="Nicolas_upshifts" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="upshifts" CDS 1303043..1304392 /gene="ktrD" /locus_tag="BSU_13500" /old_locus_tag="BSU13500" /EC_number="3.6.3.12" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 15849754, 16850406, 23963175" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 15849754, 16850406, 23963175; Product type t : transporter" /codon_start=1 /transl_table=11 /product="K+-transporting ATPase" /protein_id="NP_389233.1" /db_xref="EnsemblGenomes-Gn:BSU13500" /db_xref="EnsemblGenomes-Tr:CAB13223" /db_xref="GOA:O31658" /db_xref="InterPro:IPR003445" /db_xref="SubtiList:BG13275" /db_xref="UniProtKB/Swiss-Prot:O31658" /translation="MRLKFGKLIQALSPAQLIALYYFLAVTVAVILLSLPAAHKPGAD WTFIDALFTAVSSVSVTGLTVVDTADTFSTIGIFILAFVLQFGGIGIMTLGTFIWLIM GKRIGLKERKLIMVDQNQSQFSGIVNLMKQVLFLILWIEFFGGLILGTYFLTYYDSYQ EAYLHGFFASISATTNGGFDITGNSMIPFRHDYFVQFITMLLIIFGAIGFPVLVEVKD FLFSKHRRYPFTLFTKITTITFGSLVLFGAIGIFALEANHAFAGKSWHDILFLSLFQS TATRSGGLATIDISQLSDSTLFFICALMFIGASPSSVGGGIRTTTFALNLLALFHFAR GNKAVKVFKRELHPADLMKSLVVTMMAILLVFGATLILTITEKHSLLELLFEVCSAFG TTGLSLGITADLSSVGKCVIMIVMFIGRIGILTFLYLIGRKEIEANYHYPKERVIIG* " /label="ktrD CDS" gene 1303043..1304392 /gene="ktrD" /locus_tag="BSU_13500" /old_locus_tag="BSU13500" /label="ktrD gene" downshifts 1304380 /Source="Nicolas_upshifts" /id="D741" /incds=0 /nref=30 /ntot=182 /MaxReadThrough="0.838800000000001" /MaxDrop="4.37717" /score="20.0478288" /energy="-10.7" /TU="NA" /idTUdmin="U1093" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 1304441..1304447 /Source="Nicolas_upshift_promotors" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1304461..1304472 /Source="Nicolas_upshift_promotors" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1304469..1304536 /Source="Nicolas_S_feature" /locus_tag="new_1417493_1417560" /HighExp="S8, S6, S7, S5, ferm, nit, BT, B36, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S483" upshifts 1304469 /Source="Nicolas_upshifts" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="upshifts" CDS 1304537..1304692 /gene="ykzP" /locus_tag="BSU_13509" /old_locus_tag="BSU13509" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097718.1" /db_xref="EnsemblGenomes-Gn:BSU13509" /db_xref="EnsemblGenomes-Tr:CAX52609" /db_xref="UniProtKB/Swiss-Prot:C0H402" /translation="MKRKAEVNEAIKNNNTPTESMDPNSYKTQYHDDPNFRGANRNSK QGQQGGM*" /label="ykzP CDS" gene 1304537..1304692 /gene="ykzP" /locus_tag="BSU_13509" /old_locus_tag="BSU13509" /label="ykzP gene" CDS 1304695..1304871 /gene="ykzE" /locus_tag="BSU_13510" /old_locus_tag="BSU13510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389234.1" /db_xref="EnsemblGenomes-Gn:BSU13510" /db_xref="EnsemblGenomes-Tr:CAB13224" /db_xref="SubtiList:BG13333" /db_xref="UniProtKB/Swiss-Prot:O31659" /translation="MKKNRHSRDMQNHKKPMNKKVLEEEFSSELGDYNAGKIIETLEV TKPEKKKEKNKKQQ*" /label="ykzE CDS" gene 1304695..1304871 /gene="ykzE" /locus_tag="BSU_13510" /old_locus_tag="BSU13510" /label="ykzE gene" promotor_no_box 1304761..1304861 /Source="Nicolas_upshift_promotors" /id="U1095" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.683316683316683" /psig="0.005994005994006" /xcortree=278 /SigmaFactorBS="gaggaagaattctcaagtgaactcggggattacaatgccgga aagatcatcgaaacgctggaagtcaccaagcctgaaaagaaaaaagaaaaaaacaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1304821 /Source="Nicolas_upshifts" /id="U1095" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.683316683316683" /psig="0.005994005994006" /xcortree=278 /SigmaFactorBS="gaggaagaattctcaagtgaactcggggattacaatgccgga aagatcatcgaaacgctggaagtcaccaagcctgaaaagaaaaaagaaaaaaacaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1304867 /Source="Nicolas_upshifts" /id="D742" /incds=0 /nref=56 /ntot=112 /MaxReadThrough="2.40289" /MaxDrop="8.38761" /score="26.5107018" /energy="-19.7" /TU="NA" /idTUdmin="U1094" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(1304914..1305936) /gene="ykrP" /locus_tag="BSU_13520" /old_locus_tag="BSU13520" /EC_number="2.3.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative integral membrane protein; putative acyltransferase" /protein_id="NP_389235.1" /db_xref="EnsemblGenomes-Gn:BSU13520" /db_xref="EnsemblGenomes-Tr:CAB13225" /db_xref="GOA:O31660" /db_xref="InterPro:IPR002656" /db_xref="SubtiList:BG13276" /db_xref="UniProtKB/Swiss-Prot:O31660" /translation="MSKSRDSYFDNAKFLLIFLVVFGHILRSFINDNHFMLYLYKFIY TFHMPAFILVSGYFAKGFKRAGYVKKLAVKLIIPYLIFQIIYSVFYYIMQDESMANVN PIDPQWSLWFLVSLFFWNLLLYPFSKLSKQWALFVSCGIAVLIGYLDFVSSTLSLSRT FVFLPMFLVGFYLNKHHFDLLRSKRGKQIALGVLAAVFVICWGIDFDYSFLFGSKPYS SFGDVTLVSGLSRIGWYVLAFGATFSFLALVPQKRYFFTKWGTRTFYVYLLHGFIIKT LRQVGLEDWLTDYQSLVILLLLTAALTSVLSSNFVKTVAQPFIELRMTSLLQFVRGTG KNAYLK*" /label="ykrP CDS" gene complement(1304914..1305936) /gene="ykrP" /locus_tag="BSU_13520" /old_locus_tag="BSU13520" /label="ykrP gene" downshifts complement(1304937) /Source="Nicolas_upshifts" /id="D743" /incds=0 /nref=11 /ntot=58 /MaxReadThrough="2.29259" /MaxDrop="3.64731" /score="30.4184602" /energy="-16.9" /TU="NA" /idTUdmin="U1096" /TUdmin=92 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1305981..1306000) /Source="Nicolas_upshift_promotors" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1305997) /Source="Nicolas_upshifts" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1306012..1306018) /Source="Nicolas_upshift_promotors" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1306125..1306133 /Source="Nicolas_upshift_promotors" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1306141 /Source="Nicolas_upshifts" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1306144..1306162 /Source="Nicolas_upshift_promotors" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1306189..1308405 /gene="kinE" /locus_tag="BSU_13530" /old_locus_tag="BSU13530" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11069677, 12169614, 16166384, 25701730" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 12169614, 16166384, 25701730; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_389236.1" /db_xref="EnsemblGenomes-Gn:BSU13530" /db_xref="EnsemblGenomes-Tr:CAB13226" /db_xref="GOA:O31661" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13277" /db_xref="UniProtKB/Swiss-Prot:O31661" /translation="METLGVQTNSELREELNRLKEENARLKKELNQHQVIVNNTLDAI FICDNEMRIVQANEATERMLQVDSEDLKKRSVLDFLFSIPKDELNLSVKKFFKKGFLW KEVPIRLDCGATKYIEFLAKRGIGEDFFFVVMRDISSKKILEREFSMNEQLFKDLFDR AVDGIVLFDKDGGFIDANLSFCKSFEINHNELSHLSLYEFIDSGSRKDFDNIWKALNR KGKAKGELPVKLRSGVQKLFEFTITSNIISGFYMSIMRDITEKRSMELQLFKSEERFR EIFENAMDAIIIWSNDGRIVKANQSACKIFELPMNLLLKRKLCDFLVDSQQKYSITKR KYAKYGEIREELLFQMGNGQFKELEFTSKRTILENQHLTILRNVSDRKRMEKELRESE LKFRKVFNGSMDGNVLFDNQYRIIDANPLASHILGLSHEEIKQHSLLDIISAYEIENL ASPARQINFDEMDNEIPFLLSSGDNRKLEFSFKRNIIQNMNLAIFKDVTERKELEERL RKSDTLHVVGELAAGIAHEIRNPMTALKGFIQLLKGSVEGDYALYFNVITSELKRIES IITEFLILAKPQAIMYEEKHVTQIMRDTIDLLNAQANLSNVQMQLDLIDDIPPIYCEP NQLKQVFINILKNAIEVMPDGGNIFVTIKALDQDHVLISLKDEGIGMTEDKLKRLGEP FYTTKERGTGLGLMVSYKIIEEHQGEIMVESEEGKGTVFHITLPVRQNAEERRNDE*" /label="kinE CDS" gene 1306189..1308405 /gene="kinE" /locus_tag="BSU_13530" /old_locus_tag="BSU13530" /label="kinE gene" S_feature complement(1308180..1309120) /Source="Nicolas_S_feature" /locus_tag="new_1421204_1422144_c" /HighExp="Pyr, Glucon, C30, Glu, Mal, M/G, G/S, Heat, Fru, B36" /AntisenseName="ogt" /AntisenseCor="-0.33210294457391598" /AntisenseRegPval="-7.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S484" promotor_-35 1308258..1308265 /Source="Nicolas_upshift_promotors" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1308280..1308299 /Source="Nicolas_upshift_promotors" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1308282 /Source="Nicolas_upshifts" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="upshifts" CDS 1308402..1308899 /gene="ogt" /locus_tag="BSU_13540" /old_locus_tag="BSU13540" /EC_number="2.1.1.63" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2105461, 2308822, 2359121, 2506524, 7565865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2105461, 2308822, 2359121, 2506524, 7565865; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="O6-alkylguanine DNA alkyltransferase" /protein_id="NP_389237.1" /db_xref="EnsemblGenomes-Gn:BSU13540" /db_xref="EnsemblGenomes-Tr:CAB13227" /db_xref="GOA:P11742" /db_xref="InterPro:IPR001497" /db_xref="InterPro:IPR008332" /db_xref="InterPro:IPR014048" /db_xref="InterPro:IPR023546" /db_xref="InterPro:IPR036217" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036631" /db_xref="SubtiList:BG10848" /db_xref="UniProtKB/Swiss-Prot:P11742" /translation="MNYYTTAETPLGELIIAEEEDRITRLFLSQEDWVDWKETVQNTE HKETPNLAEAKQQLQEYFAGERKTFSLPLSQKGTPFQQKVWQALERIPYGESRSYADI AAAVGSPKAVRAVGQANKRNDLPIFVPCHRVIGKNSALTGYAGSKTEIKAFLLNIERI SYKEK*" /label="ogt CDS" gene 1308402..1308899 /gene="ogt" /locus_tag="BSU_13540" /old_locus_tag="BSU13540" /label="ogt gene" S_feature 1308900..1309139 /Source="Nicolas_S_feature" /locus_tag="new_1421924_1422163" /HighExp="Lbstat, S2, BT, BC, LPhT, dia15, LBGstat, M0t90, M9-stat, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.981549" /TUshortSig="SigA, SigH" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S485" CDS 1308989..1309114 /locus_tag="BSU_13545" /old_locus_tag="BSU13545" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513954.1" /translation="MKPSRSEKLAVFAELFVKLHILSSAQKDEIINVNKKKQKNR*" /label="hypothetical protein CDS" gene 1308989..1309114 /locus_tag="BSU_13545" /old_locus_tag="BSU13545" /label="gene" downshifts 1309107 /Source="Nicolas_upshifts" /id="D744" /incds=0 /nref=80 /ntot=239 /MaxReadThrough="1.90528" /MaxDrop="5.2481" /score="4.84132266" /energy="-15.5" /TU="NA" /idTUdmin="U1097" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1309148..1310209) /gene="mtnA" /locus_tag="BSU_13550" /old_locus_tag="BSU13550" /EC_number="5.3.1.23" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14551435, 15102328, 16511105, 17690466, 18156470" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14551435, 15102328, 16511105, 17690466, 18156470; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribose-1-phosphate isomerase (methionine salvage pathway)" /protein_id="NP_389238.1" /db_xref="EnsemblGenomes-Gn:BSU13550" /db_xref="EnsemblGenomes-Tr:CAB13228" /db_xref="GOA:O31662" /db_xref="InterPro:IPR000649" /db_xref="InterPro:IPR005251" /db_xref="InterPro:IPR011559" /db_xref="InterPro:IPR027363" /db_xref="PDB:2YRF" /db_xref="PDB:2YVK" /db_xref="SubtiList:BG13278" /db_xref="UniProtKB/Swiss-Prot:O31662" /translation="MTHSFAVPRSVEWKETAITILNQQKLPDETEYLELTTKEDVFDA IVTLKVRGAPAIGITAAFGLALAAKDIETDNVTEFRRRLEDIKQYLNSSRPTAINLSW ALERLSHSVENAISVNEAKTNLVHEAIQIQVEDEETCRLIGQNALQLFKKGDRIMTIC NAGSIATSRYGTALAPFYLAKQKDLGLHIYACETRPVLQGSRLTAWELMQGGIDVTLI TDSMAAHTMKEKQISAVIVGADRIAKNGDTANKIGTYGLAILANAFDIPFFVAAPLST FDTKVKCGADIPIEERDPEEVRQISGVRTAPSNVPVFNPAFDITPHDLISGIITEKGI MTGNYEEEIEQLFKGEKVH*" /label="mtnA CDS" gene complement(1309148..1310209) /gene="mtnA" /locus_tag="BSU_13550" /old_locus_tag="BSU13550" /label="mtnA gene" downshifts complement(1309165) /Source="Nicolas_upshifts" /id="D745" /incds=0 /nref=261 /ntot=286 /MaxReadThrough="4.47312" /MaxDrop="7.97339" /score="34.04363" /energy="-17.1" /TU="U1099,U1102" /idTUdmin="U1102" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" CDS complement(1310217..1311410) /gene="mtnK" /locus_tag="BSU_13560" /old_locus_tag="BSU13560" /EC_number="2.7.1.100" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:210167, 11545674, 15102328, 17522047, 23649237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 210167, 11545674, 15102328, 17522047, 23649237; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribose kinase (methionine salvage pathway, promiscuous)" /protein_id="NP_389239.2" /db_xref="EnsemblGenomes-Gn:BSU13560" /db_xref="EnsemblGenomes-Tr:CAB13229" /db_xref="GOA:O31663" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR009212" /db_xref="InterPro:IPR011009" /db_xref="PDB:2OLC" /db_xref="PDB:2PU8" /db_xref="PDB:2PUI" /db_xref="PDB:2PUL" /db_xref="PDB:2PUN" /db_xref="PDB:2PUP" /db_xref="SubtiList:BG13279" /db_xref="UniProtKB/Swiss-Prot:O31663" /translation="MGVTKTPLYETLNESSAVALAVKLGLFPSKSTLTCQEIGDGNLN YVFHIYDQEHDRALIIKQAVPYAKVVGESWPLTIDRARIESSALIRQGEHVPHLVPRV FYSDTEMAVTVMEDLSHLKIARKGLIEGENYPHLSQHIGEFLGKTLFYSSDYALEPKV KKQLVKQFTNPELCDITERLVFTDPFFDHDTNDFEEELRPFVEKLWNNDSVKIEAAKL KKSFLTSAETLIHGDLHTGSIFASEHETKVIDPEFAFYGPIGFDVGQFIANLFLNALS RDGADREPLYEHVNQVWETFEETFSEAWQKDSLDVYANIDGYLTDTLSHIFEEAIGFA GCELIRRTIGLAHVADLDTIVPFDKRIGRKRLALETGTAFIEKRSEFKTITDVIELFK LLVKE*" /label="mtnK CDS" gene complement(1310217..1311410) /gene="mtnK" /locus_tag="BSU_13560" /old_locus_tag="BSU13560" /label="mtnK gene" downshifts 1310277 /Source="Nicolas_upshifts" /id="D746" /incds=1 /nref=1 /ntot=51 /MaxReadThrough="3.02938" /MaxDrop="3.49719" /score="4.84132266" /energy="-15.5" /TU="NA" /idTUdmin="U1097" /TUdmin=1166 /isTUend="FALSE" /label="downshifts" downshifts complement(1311497) /Source="Nicolas_upshifts" /id="D747" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="8.61071" /MaxDrop="3.05641" /score="27.7981655" /energy="-17.6" /TU="U1099,U1102" /idTUdmin="U1102" /TUdmin="-2750" /isTUend="FALSE" /label="downshifts" misc_RNA complement(1311503..1311659) /gene="mswC" /locus_tag="BSU_misc_RNA_20" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 15102328, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 15102328, 17381305, 18039762; Product type n : RNA" /function="12: Regulatory functions" /label="mswC RNA" gene complement(1311503..1311659) /gene="mswC" /locus_tag="BSU_misc_RNA_20" /label="mswC gene" promotor_-10 complement(1311694..1311713) /Source="Nicolas_upshift_promotors" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1311695) /Source="Nicolas_upshifts" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1311729..1311736) /Source="Nicolas_upshift_promotors" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1311739..1311742 /Source="Nicolas_upshift_promotors" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1311743..1312522) /gene="mtnU" /locus_tag="BSU_13570" /old_locus_tag="BSU13570" /EC_number="3.5.1.3" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12022921, 19464248, 19596042, 21288482, 23944997, 24387040; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ketoglutaramate omega-amidase" /protein_id="NP_389240.1" /db_xref="EnsemblGenomes-Gn:BSU13570" /db_xref="EnsemblGenomes-Tr:CAB13230" /db_xref="GOA:O31664" /db_xref="InterPro:IPR003010" /db_xref="InterPro:IPR036526" /db_xref="SubtiList:BG13280" /db_xref="UniProtKB/Swiss-Prot:O31664" /translation="MKWTISCLQFDISYGKPSENIKKAEFFIEKESKHADVLVLPELW TTGYDLANLDELADEDGRSAQSWLKKTAKKHGVHIVAGSVAVRKNSDVYNTMYIADKE GQIIKEYRKAHLFQLMDEHLYLSAGSEDGYFELDGVKSSGLICYDIRFPEWIRKHTTK GANVLFISAEWPLPRLDHWKSLLIARAIENQCFVAACNCTGSNPDNEFAGHSLIIDPW GRVLAEGGREEGIVRAEIDLQESAEVRESIPVFDDIRKDLY*" /label="mtnU CDS" gene complement(1311743..1312522) /gene="mtnU" /locus_tag="BSU_13570" /old_locus_tag="BSU13570" /label="mtnU gene" promotor_-10 1311758..1311777 /Source="Nicolas_upshift_promotors" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1311767 /Source="Nicolas_upshifts" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1312215..1312222 /Source="Nicolas_upshift_promotors" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="promotor_-35" promotor_-10 1312235..1312254 /Source="Nicolas_upshift_promotors" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="promotor_-10" upshifts 1312250 /Source="Nicolas_upshifts" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="upshifts" S_feature 1312257..1312574 /Source="Nicolas_S_feature" /locus_tag="new_1425281_1425598" /HighExp="LoTm, S8, C30, BC, S7, B36, B60, T2.0H, Sw, UNK1" /AntisenseName="mtnU" /AntisenseCor="0.77659263363209297" /AntisenseRegPval="-54.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S486" promotor_-35 1312544..1312551 /Source="Nicolas_upshift_promotors" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1312552..1312571) /Source="Nicolas_upshift_promotors" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1312566..1312585 /Source="Nicolas_upshift_promotors" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1312566) /Source="Nicolas_upshifts" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="upshifts" upshifts 1312576 /Source="Nicolas_upshifts" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1312587..1312594) /Source="Nicolas_upshift_promotors" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1312617..1313813 /gene="mtnE" /locus_tag="BSU_13580" /old_locus_tag="BSU13580" /EC_number="2.6.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 15102328, 23429746, 24387040" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 15102328, 23429746, 24387040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine-glutamine aminotransferase" /protein_id="NP_389241.1" /db_xref="EnsemblGenomes-Gn:BSU13580" /db_xref="EnsemblGenomes-Tr:CAB13231" /db_xref="GOA:O31665" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13281" /db_xref="UniProtKB/Swiss-Prot:O31665" /translation="MKFEQSHVLKELPKQFFASLVQKVNRKLAEGHDVINLGQGNPDQ PTPEHIVEEMKRAVADPENHKYSSFRGSYRLKSAAAAFYKREYGIDLDPETEVAVLFG GKAGLVELPQCLLNPGDTILVPDPGYPDYWSGVTLAKAKMEMMPLVKDRAFLPDYSSI TAEIREQAKLMYLNYPNNPTGAVATSEFFEDTVRFAAENGICVVHDFAYGAVGFDGCK PLSFLQTEGAKDIGIEIYTLSKTYNMAGWRVGFAVGNASVIEAINLYQDHMFVSLFRA TQEAAAEALLADQTCVAEQNARYESRRNAWITACREIGWDVTAPAGSFFAWLPVPEGY TSEQFSDLLLEKANVAVAAGNGFGEYGEGYVRVGLLTSEERLKEAAYRIGKLNLFTQK SIDKTL*" /label="mtnE CDS" gene 1312617..1313813 /gene="mtnE" /locus_tag="BSU_13580" /old_locus_tag="BSU13580" /label="mtnE gene" promotor_-35 1313795..1313802 /Source="Nicolas_upshift_promotors" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1313817..1313836 /Source="Nicolas_upshift_promotors" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1313836 /Source="Nicolas_upshifts" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1313852..1313952 /gene="mswD" /locus_tag="BSU_misc_RNA_21" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 15102328, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 15102328, 17381305, 18039762; Product type n : RNA" /function="16.3: Control" /label="mswD RNA" gene 1313852..1313952 /gene="mswD" /locus_tag="BSU_misc_RNA_21" /label="mswD gene" downshifts 1313951 /Source="Nicolas_upshifts" /id="D748" /incds=0 /nref=49 /ntot=190 /MaxReadThrough="7.27369" /MaxDrop="4.19981" /score="-1.80590532" /energy="-10.7" /TU="U1103,U1104" /idTUdmin="U1101" /TUdmin=110 /isTUend="FALSE" /label="downshifts" CDS 1314037..1315254 /gene="mtnW" /locus_tag="BSU_13590" /old_locus_tag="BSU13590" /EC_number="5.3.2.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 15950120, 16737967, 18403380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 15950120, 16737967, 18403380; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="2,3-diketo-5-methylthiopentyl-1-phosphate enolase (DK-MTP-1-P enolase)" /protein_id="NP_389242.2" /db_xref="EnsemblGenomes-Gn:BSU13590" /db_xref="EnsemblGenomes-Tr:CAB13232" /db_xref="GOA:O31666" /db_xref="InterPro:IPR000685" /db_xref="InterPro:IPR017443" /db_xref="InterPro:IPR017717" /db_xref="InterPro:IPR033966" /db_xref="InterPro:IPR036376" /db_xref="InterPro:IPR036422" /db_xref="PDB:2ZVI" /db_xref="SubtiList:BG13282" /db_xref="UniProtKB/Swiss-Prot:O31666" /translation="MSELLATYLLTEPGADTEKKAEQIATGLTVGSWTDLPLVKQEQM QKHKGRVIKVEEREGTAASEKQAVITIAYPEINFSQDIPALLTTVFGKLSLDGKIKLI DLHFSEAFKRALPGPKFGVYGIRKLLGEFERPLLMSIFKGVIGRDLSDIKEQLRQQAL GGVDLIKDDEIFFETGLAPFETRIAEGKQILKETYEQTGHKTLYAVNLTGRTADLKDK ARRAAELGADALLFNVFAYGLDVMQGLAEDPEIPVPIMAHPAVSGAFTSSPFYGFSHA LLLGKLNRYCGADFSLFPSPYGSVALPRADALAIHEECVREDAFNQTFAVPSAGIHPG MVPLLMRDFGIDHIINAGGGVHGHPNGAQGGGRAFRAIIDAVLEAQPIDEKAEQCKDL KLALDKWGKAEAV*" /label="mtnW CDS" gene 1314037..1315254 /gene="mtnW" /locus_tag="BSU_13590" /old_locus_tag="BSU13590" /label="mtnW gene" CDS 1315251..1315958 /gene="mtnX" /locus_tag="BSU_13600" /old_locus_tag="BSU13600" /EC_number="3.1.3.87" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 15950120, 17654724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 15950120, 17654724; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-hydroxy-3-keto-5-methylthiopentenyl-1- phosphatephosphatase (HK-MTPenyl-1-P phosphatase)" /protein_id="NP_389243.1" /db_xref="EnsemblGenomes-Gn:BSU13600" /db_xref="EnsemblGenomes-Tr:CAB13233" /db_xref="GOA:O31667" /db_xref="InterPro:IPR006384" /db_xref="InterPro:IPR017718" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:2FEA" /db_xref="SubtiList:BG13283" /db_xref="UniProtKB/Swiss-Prot:O31667" /translation="MTTRKPFIICDFDGTITMNDNIINIMKTFAPPEWMALKDGVLSK TLSIKEGVGRMFGLLPSSLKEEITSFVLEDAKIREGFREFVAFINEHEIPFYVISGGM DFFVYPLLEGIVEKDRIYCNHASFDNDYIHIDWPHSCKGTCSNQCGCCKPSVIHELSE PNQYIIMIGDSVTDVEAAKLSDLCFARDYLLNECREQNLNHLPYQDFYEIRKEIENVK EVQEWLQNKNAGESSLK*" /label="mtnX CDS" gene 1315251..1315958 /gene="mtnX" /locus_tag="BSU_13600" /old_locus_tag="BSU13600" /label="mtnX gene" CDS 1315916..1316545 /gene="mtnB" /locus_tag="BSU_13610" /old_locus_tag="BSU13610" /EC_number="4.2.1.109" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 18391471, 23285211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 18391471, 23285211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase)" /protein_id="NP_389244.1" /db_xref="EnsemblGenomes-Gn:BSU13610" /db_xref="EnsemblGenomes-Tr:CAB13234" /db_xref="GOA:O31668" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR017714" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG13284" /db_xref="UniProtKB/Swiss-Prot:O31668" /translation="MAAKQERWRELAEVKRELAERDWFPATSGNLSIKVTDEPLTFLV TASGKDKRKETVEDFLLVDQNGEPAESGHSLKPSAETLLHTHLYNKTNAGCCLHVHTV NNNVISELYGDQKKITFKGQEIIKALGLWEENAEVTVPIIENPAHIPTLAALFAEEIS EDSGAVLIRNHGITAWGKTAFEAKRVLEAYEFLFSYHLKLKTLEHQLVK*" /label="mtnB CDS" gene 1315916..1316545 /gene="mtnB" /locus_tag="BSU_13610" /old_locus_tag="BSU13610" /label="mtnB gene" CDS 1316560..1317096 /gene="mtnD" /locus_tag="BSU_13620" /old_locus_tag="BSU13620" /EC_number="1.13.11.54" /EC_number="1.13.11.53" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10704478, 11371200, 12022880, 12022921, 12402029, 15102328, 16297065, 16783794, 24036122" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10704478, 11371200, 12022880, 12022921, 12402029, 15102328, 16297065, 16783794, 24036122; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acireductone dioxygenase (Ni2+ or Fe2+-requiring)" /protein_id="NP_389245.1" /db_xref="EnsemblGenomes-Gn:BSU13620" /db_xref="EnsemblGenomes-Tr:CAB13235" /db_xref="GOA:O31669" /db_xref="InterPro:IPR004313" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR023956" /db_xref="SubtiList:BG13285" /db_xref="UniProtKB/Swiss-Prot:O31669" /translation="MATIRIHDEANTTIENQEEVASFLDSQEVIYEQWDITRLPEHLS EKYDLTEEEKQQILDTFETEIKDISTRRGYKAQDVISLSDSNPKLDELLENFKREHHH TDDEVRFIVSGHGIFVIQGQDGTFFDVRLNPGDLISVPENIRHYFTLQEDRKVVAVRI FVTTEGWVPIYEKDSVNQ*" /label="mtnD CDS" gene 1316560..1317096 /gene="mtnD" /locus_tag="BSU_13620" /old_locus_tag="BSU13620" /label="mtnD gene" S_feature complement(1316943..1317136) /Source="Nicolas_S_feature" /locus_tag="new_1429967_1430160_c" /HighExp="Lbstat, Cold, LBGstat, T0.30H, M9-stat, B60, ferm, T1.30H, LPhT, M0t90" /AntisenseName="mtnD" /AntisenseCor="-0.31139057410816301" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S487" downshifts 1317096 /Source="Nicolas_upshifts" /id="D749" /incds=0 /nref=179 /ntot=227 /MaxReadThrough="1.58976" /MaxDrop="6.10661" /score="35.4563733" /energy="-14.9" /TU="NA" /idTUdmin="U1103" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1317137..1317457) /gene="ykvA" /locus_tag="BSU_13630" /old_locus_tag="BSU13630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389246.1" /db_xref="EnsemblGenomes-Gn:BSU13630" /db_xref="EnsemblGenomes-Tr:CAB13236" /db_xref="GOA:O31670" /db_xref="InterPro:IPR010652" /db_xref="SubtiList:BG13308" /db_xref="UniProtKB/Swiss-Prot:O31670" /translation="MKKKKAIMLGAAGGKAILKRKNRKKCIQHITTFFQMLRDWRNGD YPRSQVKTLLLLTAAILYIVMPLDIIPDVILGLGFIDDAAVLGLIWTLIKKELSQYEK WRLQ*" /label="ykvA CDS" gene complement(1317137..1317457) /gene="ykvA" /locus_tag="BSU_13630" /old_locus_tag="BSU13630" /label="ykvA gene" downshifts complement(1317195) /Source="Nicolas_upshifts" /id="D750" /incds=0 /nref=5 /ntot=148 /MaxReadThrough="4.05831" /MaxDrop="2.74575" /score="18.5455371" /energy="-11.3" /TU="U1106" /idTUdmin="U1106" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" S_feature complement(1317458..1317547) /Source="Nicolas_S_feature" /locus_tag="new_1430482_1430571_c" /HighExp="Lbstat, M9-stat, B60, T0.30H, LBGstat, M0t90, T1.0H, S2, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S488" promotor_-35 1317483..1317489 /Source="Nicolas_upshift_promotors" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1317504..1317522 /Source="Nicolas_upshift_promotors" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1317514 /Source="Nicolas_upshifts" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="upshifts" S_feature 1317515..1317599 /Source="Nicolas_S_feature" /locus_tag="new_1430539_1430623" /HighExp="Etha, Gly, BC, Salt, Sw, B60, LoTm, M9-stat, LPhT, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S489" promotor_-10 complement(1317529..1317548) /Source="Nicolas_upshift_promotors" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1317546) /Source="Nicolas_upshifts" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1317563..1317566) /Source="Nicolas_upshift_promotors" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1317573..1317580 /Source="Nicolas_upshift_promotors" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1317595..1317614 /Source="Nicolas_upshift_promotors" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1317601..1317659 /Source="Nicolas_S_feature" /locus_tag="new_1430625_1430683" /HighExp="Etha, Gly, Sw, BC, LoTm, B36, T3.30H, Salt, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S490" upshifts 1317601 /Source="Nicolas_upshifts" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1317657) /Source="Nicolas_upshifts" /id="D751" /incds=0 /nref=3 /ntot=61 /MaxReadThrough="0.87927" /MaxDrop="3.53961" /score="18.5455371" /energy="-11.3" /TU="NA" /idTUdmin="U1106" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" CDS 1317660..1317917 /gene="spo0E" /locus_tag="BSU_13640" /old_locus_tag="BSU13640" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15057450, 15916600, 17001075, 19332814, 22524514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15057450, 15916600, 17001075, 19332814, 22524514; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="negative regulatory phosphatase acting on Spo0A-P (sporulation)" /protein_id="NP_389247.1" /db_xref="EnsemblGenomes-Gn:BSU13640" /db_xref="EnsemblGenomes-Tr:CAB13237" /db_xref="GOA:P05043" /db_xref="InterPro:IPR018540" /db_xref="InterPro:IPR037208" /db_xref="SubtiList:BG10769" /db_xref="UniProtKB/Swiss-Prot:P05043" /translation="MGGSSEQERLLVSIDEKRKLMIDAARKQGFTGHDTIRHSQELDC LINEYHQLMQENEHSQGIQGLVKKLGLWPRRDVMPAYDANK*" /label="spo0E CDS" gene 1317660..1317917 /gene="spo0E" /locus_tag="BSU_13640" /old_locus_tag="BSU13640" /label="spo0E gene" downshifts 1317911 /Source="Nicolas_upshifts" /id="D752" /incds=0 /nref=7 /ntot=169 /MaxReadThrough="4.39402" /MaxDrop="3.59614" /score="0.224700481" /energy="-5.9" /TU="U1105,U1107" /idTUdmin="U1105" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" CDS 1318003..1318434 /gene="eag" /locus_tag="BSU_13650" /old_locus_tag="BSU13650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative small membrane protein" /protein_id="NP_389248.1" /db_xref="EnsemblGenomes-Gn:BSU13650" /db_xref="EnsemblGenomes-Tr:CAB13238" /db_xref="GOA:P06630" /db_xref="SubtiList:BG10770" /db_xref="UniProtKB/Swiss-Prot:P06630" /translation="MKELAILITEMVNQFHDAFISLCGIFGIHLTDKEMHFWVIGIFG IFFFGVTHAVFTWLSKWSMTALSFIYTVTVIIVIVFAIEIQQKVTGRGNMEFLDATEG IKGFLVFFMFFLLLKMLLRFIKILFSGRPASKSNGNARSRR*" /label="eag CDS" gene 1318003..1318434 /gene="eag" /locus_tag="BSU_13650" /old_locus_tag="BSU13650" /label="eag gene" CDS complement(1318462..1319982) /gene="kinD" /locus_tag="BSU_13660" /old_locus_tag="BSU13660" /EC_number="2.7.13.3" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11069677, 11673427, 16166384, 10411754, 21622736, 22074846, 22716461, 23569226" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 11673427, 16166384, 10411754, 21622736, 22074846, 22716461, 23569226; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidine kinase phosphorylating Spo0A" /protein_id="NP_389249.1" /db_xref="EnsemblGenomes-Gn:BSU13660" /db_xref="EnsemblGenomes-Tr:CAB13239" /db_xref="GOA:O31671" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:4JGO" /db_xref="PDB:4JGP" /db_xref="PDB:4JGQ" /db_xref="PDB:4JGR" /db_xref="SubtiList:BG13309" /db_xref="UniProtKB/Swiss-Prot:O31671" /translation="MLERCKLKILKGACGRVKLYIILVVIPAIVISFFVYEKEKDTIA AEHKQEASVLLNLHRNKINYLIGETMARMTSLSIAIDRPVDIKKMQSILEKTFDSEPR FSGLYFLNAKGDVTASTTELKTKVNLADRSFFIKAKETKKTVISDSYSSRITGQPIFT ICVPVLDSKRNVTDYLVAAIQIDYLKNLINLLSPDVYIEVVNQDGKMIFASGQASHAE DQKPVSGYLDDISWNMKVYPNPVTIEELSKSLVLPLSCIIVLLNILFILVLYYLLKRQ TQLERSENEAQKLELIGTLAASTAHEIRNPLTGISGFIQLLQKKYKGEEDQLYFSIIE QEIKRINQIVSEFLVLGKPTAEKWELNSLQDIIGEIMPIIYSEGNLYNVEVELQYLTE QPLLVKCTKDHIKQVILNVAKNGLESMPEGGKLTISLGALDKKAIIKVVDNGEGISQE MLDHIFLPFVTSKEKGTGLGLVVCKRIVLMYGGSIHIESEVRRGTEVTITLPVSAS*" /label="kinD CDS" gene complement(1318462..1319982) /gene="kinD" /locus_tag="BSU_13660" /old_locus_tag="BSU13660" /label="kinD gene" downshifts complement(1318474) /Source="Nicolas_upshifts" /id="D753" /incds=0 /nref=106 /ntot=227 /MaxReadThrough="0.62895" /MaxDrop="5.24795" /score="18.5455371" /energy="-11.3" /TU="NA" /idTUdmin="U1109" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 1319183..1319189 /Source="Nicolas_upshift_promotors" /id="U1108" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=948 /SigmaFactorBS="ctgggtctgccgcttcagcaaataatacagcacgAGAATAAa aaggatattcagCAGAACAATAATacatgaaagcggaagcacaaggcttttcgacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1319203..1319214 /Source="Nicolas_upshift_promotors" /id="U1108" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=948 /SigmaFactorBS="ctgggtctgccgcttcagcaaataatacagcacgAGAATAAa aaggatattcagCAGAACAATAATacatgaaagcggaagcacaaggcttttcgacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1319209 /Source="Nicolas_upshifts" /id="U1108" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=948 /SigmaFactorBS="ctgggtctgccgcttcagcaaataatacagcacgAGAATAAa aaggatattcagCAGAACAATAATacatgaaagcggaagcacaaggcttttcgacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1319990..1320009) /Source="Nicolas_upshift_promotors" /id="U1109" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2145 /SigmaFactorBS="aagcttgccaacatctttttctaatttttttggttatttttt cttattaaagaagaagaaacAATGATATAATACCTCTAATcaggtgtatgttggagcg a" /listShort="kinD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1320011) /Source="Nicolas_upshifts" /id="U1109" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2145 /SigmaFactorBS="aagcttgccaacatctttttctaatttttttggttatttttt cttattaaagaagaagaaacAATGATATAATACCTCTAATcaggtgtatgttggagcg a" /listShort="kinD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1320109..1320116 /Source="Nicolas_upshift_promotors" /id="U1110" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2454 /SigmaFactorBS="cattttaaaaaagaagagaaatattggaaagattttTATTGA CAttttggtctttgttTATTAATGTTTCTCTGTAACggtttctaaaaggatgattgag a" /listShort="mhqR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1320131..1320150 /Source="Nicolas_upshift_promotors" /id="U1110" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2454 /SigmaFactorBS="cattttaaaaaagaagagaaatattggaaagattttTATTGA CAttttggtctttgttTATTAATGTTTCTCTGTAACggtttctaaaaggatgattgag a" /listShort="mhqR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1320133 /Source="Nicolas_upshifts" /id="U1110" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2454 /SigmaFactorBS="cattttaaaaaagaagagaaatattggaaagattttTATTGA CAttttggtctttgttTATTAATGTTTCTCTGTAACggtttctaaaaggatgattgag a" /listShort="mhqR" /GFF_Attribute="listLong" /label="upshifts" CDS 1320175..1320612 /gene="mhqR" /locus_tag="BSU_13670" /old_locus_tag="BSU13670" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17725564, 17962296, 18282125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17725564, 17962296, 18282125; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MarR family)" /protein_id="NP_389250.1" /db_xref="EnsemblGenomes-Gn:BSU13670" /db_xref="EnsemblGenomes-Tr:CAB13240" /db_xref="GOA:O31672" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13310" /db_xref="UniProtKB/Swiss-Prot:O31672" /translation="MTEKSLKLFIVLSRAYRSINDHMNKHIHKHGLNPTEFAVLELLY HKGDQPLQQIGDKILLASGSITYVVDKLEQKELLIRKASPTDRRVTFAQITEKGIGLL NDIFPDHAAEIDEMISVLSEEEVEMCTEMLKRVGLNAKQFHNK*" /label="mhqR CDS" gene 1320175..1320612 /gene="mhqR" /locus_tag="BSU_13670" /old_locus_tag="BSU13670" /label="mhqR gene" downshifts 1320595 /Source="Nicolas_upshifts" /id="D754" /incds=0 /nref=210 /ntot=257 /MaxReadThrough="1.20686" /MaxDrop="5.47215" /score="1.59181784" /energy="-8.9" /TU="U1110" /idTUdmin="U1110" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1320652..1321437) /gene="motB" /locus_tag="BSU_13680" /old_locus_tag="BSU13680" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16095621, 18566286, 24296669, 24771657, 25273986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16095621, 18566286, 24296669, 24771657, 25273986; Product type f: factor" /codon_start=1 /transl_table=11 /product="motility protein B; MotB component of the H+-coupled stator flagellum complex" /protein_id="NP_389251.1" /db_xref="EnsemblGenomes-Gn:BSU13680" /db_xref="EnsemblGenomes-Tr:CAB13241" /db_xref="GOA:P28612" /db_xref="InterPro:IPR006665" /db_xref="InterPro:IPR025713" /db_xref="InterPro:IPR036737" /db_xref="SubtiList:BG10689" /db_xref="UniProtKB/Swiss-Prot:P28612" /translation="MARKKKKKHEDEHVDESWLVPYADILTLLLALFIVLYASSSIDA AKFQMLSKSFNEVFTGGTGVLDYSSVTPPENESDGIDEVKKEKEEKEKNKKEKEKAAD QEELENVKSQVEKFIKDKKLEHQLETKMTSEGLLITIKDSIFFDSGKATIRKEDVPLA KEISNLLVINPPRNIIISGHTDNMPIKNSEFQSNWHLSVMRAVNFMGLLIENPKLDAK VFSAKGYGEYKPVASNKTAEGRSKNRRVEVLILPRGAAETNEK*" /label="motB CDS" gene complement(1320652..1321437) /gene="motB" /locus_tag="BSU_13680" /old_locus_tag="BSU13680" /label="motB gene" downshifts complement(1320671) /Source="Nicolas_upshifts" /id="D755" /incds=0 /nref=224 /ntot=246 /MaxReadThrough="3.05351" /MaxDrop="6.69306" /score="21.3673767" /energy="-12.4" /TU="U1111" /idTUdmin="U1111" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts complement(1321133) /Source="Nicolas_upshifts" /id="D756" /incds=1 /nref=1 /ntot=19 /MaxReadThrough="8.03566" /MaxDrop="4.69358" /score="21.3673767" /energy="-12.4" /TU="U1111" /idTUdmin="U1111" /TUdmin="-550" /isTUend="FALSE" /label="downshifts" CDS complement(1321409..1322221) /gene="motA" /locus_tag="BSU_13690" /old_locus_tag="BSU13690" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16095621, 18566286, 24296669, 24771657, 25273986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16095621, 18566286, 24296669, 24771657, 25273986; Product type f: factor" /codon_start=1 /transl_table=11 /product="motility protein A; MotA component of the H+-coupled stator flagellum complex" /protein_id="NP_389252.1" /db_xref="EnsemblGenomes-Gn:BSU13690" /db_xref="EnsemblGenomes-Tr:CAB13242" /db_xref="GOA:P28611" /db_xref="InterPro:IPR000540" /db_xref="InterPro:IPR002898" /db_xref="SubtiList:BG10688" /db_xref="UniProtKB/Swiss-Prot:P28611" /translation="MDKTSLIGIILAFVALSVGMVLKGVSFSALANPAAILIIIAGTI SAVVIAFPTKEIKKVPTLFRVLFKENKQLTIEELIPMFSEWAQLARREGLLALEASIE DVDDAFLKNGLSMAVDGQSAEFIRDIMTEEVEAMEDRHQAGAAIFTQAGTYAPTLGVL GAVIGLIAALSHMDNTDELGHAISAAFVATLLGIFTGYVLWHPFANKLKRKSKQEVKL REVMIEGVLSVLEGQAPKVIEQKLLMYLPAKDRLKFAEQGEAQNGEKKEEEA*" /label="motA CDS" gene complement(1321409..1322221) /gene="motA" /locus_tag="BSU_13690" /old_locus_tag="BSU13690" /label="motA gene" promotor_-10 complement(1322252..1322270) /Source="Nicolas_upshift_promotors" /id="U1111" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2801 /SigmaFactorBS="tcttccttgaatatttcatgaacaaattcacaatgtcCCTAA AGTtccgggcaccaaaACCGATATTAACCATAGACaagctagtaaaaaaggatttggt g" /listShort="motA, motB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1322268) /Source="Nicolas_upshifts" /id="U1111" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2801 /SigmaFactorBS="tcttccttgaatatttcatgaacaaattcacaatgtcCCTAA AGTtccgggcaccaaaACCGATATTAACCATAGACaagctagtaaaaaaggatttggt g" /listShort="motA, motB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1322284..1322291) /Source="Nicolas_upshift_promotors" /id="U1111" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2801 /SigmaFactorBS="tcttccttgaatatttcatgaacaaattcacaatgtcCCTAA AGTtccgggcaccaaaACCGATATTAACCATAGACaagctagtaaaaaaggatttggt g" /listShort="motA, motB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1322359..1322581) /Source="Nicolas_S_feature" /locus_tag="new_1435383_1435605_c" /HighExp="Diami, dia15, dia5, Heat, Etha, LPhT, H2O2, C30, G135, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.93062599999999995" /TUshortSig="SigA" /TUshortPSig="0.671" /TUlongSig="NA" /TUlongPSig="NA" /label="S491" downshifts complement(1322391) /Source="Nicolas_upshifts" /id="D757" /incds=0 /nref=5 /ntot=12 /MaxReadThrough="0.48394" /MaxDrop="4.60081" /score="30.9355071" /energy="-15.4" /TU="NA" /idTUdmin="U1112" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1322604..1324703) /gene="clpE" /locus_tag="BSU_13700" /old_locus_tag="BSU13700" /function="16.3: Control" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9987115, 10320580, 11069659, 14679237, 16788169, 16899079, 18689473, 19226326, 21208299, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987115, 10320580, 11069659, 14679237, 16788169, 16899079, 18689473, 19226326, 21208299, 28333276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent Clp protease (class III stress gene)" /protein_id="NP_389253.1" /db_xref="EnsemblGenomes-Gn:BSU13700" /db_xref="EnsemblGenomes-Tr:CAB13243" /db_xref="GOA:O31673" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR018368" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028299" /db_xref="SubtiList:BG12578" /db_xref="UniProtKB/Swiss-Prot:O31673" /translation="MRCQHCHQNEATIRLNMQINSVHKQMVLCETCYNELTRKPSMSM GPQSFGFPFEQAFQPKEQSAAKQSEKKGLLDELAQNITNGAKAGLIDPVIGRDDEVAR VIEILNRRNKNNPVLIGEPGVGKTAIAEGLALKIAEGDVPNKLKNKELYLLDVASLVA NTGIRGQFEERMKQLITELKERKNVILFIDEIHLLVGAGSAEGSMDAGNILKPALARG ELQVIGATTLKEYRQIEKDAALERRFQPVMVQEPSIEQAILILQGIKDKYEAYHGVTF SDEAIKACVTLSSRYIQDRHLPDKAIDLLDEAGSKANLLIDELNDEDAAERLTAIEAE KTKALEEENYELAAKLRDEELALEKKLNSSSAHTAVTVEAEHIQEIVEQKTGIPVGKL QADEQTKMKELEAKLHERVIGQEAAVQKVAKAVRRSRAGLKSKNRPVGSFLFVGPTGV GKTELSKTLADELFGTKDAIIRLDMSEYMEKHAVSKIIGSPPGYVGHEEAGQLTEKVR RNPYSIVLLDEIEKAHPDVQHMFLQIMEDGRLTDSQGRTVSFKDTVIIMTSNAGAGEK QTKVGFQSDDSVIEEQTLIDSLSMFFKPEFLNRFDSIIEFRSLEKEHLVKIVSLLLGE LEETLAERGISLNVTDEAKEKIAELGYHPSFGARPLRRTIQEWVEDEMTDLLLDNGEI TSFHVILEDDKIKVRAK*" /label="clpE CDS" gene complement(1322604..1324703) /gene="clpE" /locus_tag="BSU_13700" /old_locus_tag="BSU13700" /label="clpE gene" downshifts complement(1322626) /Source="Nicolas_upshifts" /id="D758" /incds=0 /nref=27 /ntot=132 /MaxReadThrough="4.1802" /MaxDrop="6.07862" /score="41.2563375" /energy="-13.6" /TU="U1112" /idTUdmin="U1112" /TUdmin="-239" /isTUend="FALSE" /label="downshifts" S_feature complement(1324704..1324954) /Source="Nicolas_S_feature" /locus_tag="new_1437728_1437978_c" /HighExp="dia5, Heat, Diami, LPhT, dia15, H2O2, HiTm, S2, Cold, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.671" /TUlongSig="NA" /TUlongPSig="NA" /label="S492" promotor_no_box complement(1324914..1325014) /Source="Nicolas_upshift_promotors" /id="U1112" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.437562437562438" /psig="0.671328671328671" /xcortree=2025 /SigmaFactorBS="atgagacaagttccttgaaaagacgaagaaaacatgttttac tttgtaacaaatcaaaaatttttgtgcataagacttgaaagtcaaagatagtcagagt a" /listShort="S492, clpE, S491" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1324954) /Source="Nicolas_upshifts" /id="U1112" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.437562437562438" /psig="0.671328671328671" /xcortree=2025 /SigmaFactorBS="atgagacaagttccttgaaaagacgaagaaaacatgttttac tttgtaacaaatcaaaaatttttgtgcataagacttgaaagtcaaagatagtcagagt a" /listShort="S492, clpE, S491" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1324990..1324995 /Source="Nicolas_upshift_promotors" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1325005 /Source="Nicolas_upshifts" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1325011..1325029 /Source="Nicolas_upshift_promotors" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1325068..1326111 /gene="ykvI" /locus_tag="BSU_13710" /old_locus_tag="BSU13710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836, 15849754, 16850406, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_389254.1" /db_xref="EnsemblGenomes-Gn:BSU13710" /db_xref="EnsemblGenomes-Tr:CAB13244" /db_xref="GOA:O31674" /db_xref="SubtiList:BG13311" /db_xref="UniProtKB/Swiss-Prot:O31674" /translation="MEQSKGSASQLAFVYVGTVVGAGFATGREIVEFFLKFGWFGFFG ILVSGGMFTLLGAKLMIISKRINAKSYQEMNIFLFGATAGRIINVFMLFVLLGVTSVM LSGAGALFEEQLGMSAQIGMLITIGLSLIVMTRGVKGIFGVNVFVVPLLIIFSMIVVA DSFIFSESRNAAQWVWPHRWDWLLSAVSYGALNLSLAQAVLVPLANEMSSEKVIKKGA LIGGTMLTIVLSASFLSLSTLPDVFLYDIPMAQVVYLFARSVHLIYLLIIFGEVFTSV IGNLYGLEKQVQSFLPVKSKYIFAAIMITAYITSQIGYGRLISTIYPLFGYVSLAFIG ALLCKKAPRRRSL*" /label="ykvI CDS" gene 1325068..1326111 /gene="ykvI" /locus_tag="BSU_13710" /old_locus_tag="BSU13710" /label="ykvI gene" S_feature 1326112..1326203 /Source="Nicolas_S_feature" /locus_tag="new_1439136_1439227" /HighExp="S3, LoTm, S4, S5, BT, M9-stat, S6, T5.0H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S493" promotor_-35 1326180..1326184 /Source="Nicolas_upshift_promotors" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1326201..1326220 /Source="Nicolas_upshift_promotors" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1326205 /Source="Nicolas_upshifts" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1326250..1326294 /gene="qswA" /locus_tag="BSU_misc_RNA_22" /product="preQ1 riboswitch" /experiment="publication(s) with functional evidences, PMID:17384645, 19234468, 19285444, 20534493, 21410253, 21592962, 24798077, 27484311" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17384645, 19234468, 19285444, 20534493, 21410253, 21592962, 24798077, 27484311; Product type n: RNA" /function="16.3: Control" /label="qswA RNA" gene 1326250..1326294 /gene="qswA" /locus_tag="BSU_misc_RNA_22" /label="qswA gene" downshifts 1326271 /Source="Nicolas_upshifts" /id="D759" /incds=0 /nref=11 /ntot=17 /MaxReadThrough="7.29177" /MaxDrop="4.09959" /score="21.1398563" /energy="-9.5" /TU="U1114" /idTUdmin="U1113" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1326316..1326423 /Source="Nicolas_S_feature" /locus_tag="new_1439340_1439447" /HighExp="Paraq, ferm, G180, LBGstat, Diami, H2O2, LPhT, Oxctl, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S494" CDS 1326424..1327083 /gene="queC" /locus_tag="BSU_13720" /old_locus_tag="BSU13720" /EC_number="6.3.4.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14660578, 16199558, 17384645, 18491386, 19354300" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14660578, 16199558, 17384645, 18491386, 19354300; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pre-queuosine 0 synthase" /protein_id="NP_389255.1" /db_xref="EnsemblGenomes-Gn:BSU13720" /db_xref="EnsemblGenomes-Tr:CAB13245" /db_xref="GOA:O31675" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR018317" /db_xref="PDB:3BL5" /db_xref="SubtiList:BG13312" /db_xref="UniProtKB/Swiss-Prot:O31675" /translation="MKKEKAIVVFSGGQDSTTCLLWALKEFEEVETVTFHYNQRHSQE VEVAKSIAEKLGVKNHLLDMSLLNQLAPNALTRNDIEIEVKDGELPSTFVPGRNLVFL SFASILAYQIGARHIITGVCETDFSGYPDCRDEFVKSCNVTVNLAMEKPFVIHTPLMW LNKAETWKLADELGALDFVKNNTLTCYNGIIADGCGECPACHLRSKGYEEYMVMKGER A*" /label="queC CDS" gene 1326424..1327083 /gene="queC" /locus_tag="BSU_13720" /old_locus_tag="BSU13720" /label="queC gene" CDS 1327076..1327525 /gene="queD" /locus_tag="BSU_13730" /old_locus_tag="BSU13730" /EC_number="4.1.2.50" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 18259064, 19231875" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 18259064, 19231875; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-carboxy-5,6,7,8-tetrahydropterin synthase; queuosine biosynthesis" /protein_id="NP_389256.1" /db_xref="EnsemblGenomes-Gn:BSU13730" /db_xref="EnsemblGenomes-Tr:CAB13246" /db_xref="GOA:O31676" /db_xref="InterPro:IPR007115" /db_xref="SubtiList:BG13313" /db_xref="UniProtKB/Swiss-Prot:O31676" /translation="MHKLLSQIYPQAQHPYSFELNKDMHISAAHFIPRESAGACSRVH GHTYTVNITVAGDELDDSGFLVNFSVLKKLVHGNYDHTLLNDHEDFSQDDRYSLPTTE VVAKTIYDNVQAYLDTLENKPTCVQVFVRETPTSYCVYRPKKGGLNG*" /label="queD CDS" gene 1327076..1327525 /gene="queD" /locus_tag="BSU_13730" /old_locus_tag="BSU13730" /label="queD gene" CDS 1327518..1328249 /gene="queE" /locus_tag="BSU_13740" /old_locus_tag="BSU13740" /EC_number="4.3.99.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 19354300, 23194065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 19354300, 23194065; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="7-carboxy-7-deazaguanine synthase" /protein_id="NP_389257.1" /db_xref="EnsemblGenomes-Gn:BSU13740" /db_xref="EnsemblGenomes-Tr:CAB13247" /db_xref="GOA:O31677" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR017742" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR024924" /db_xref="PDB:5TGS" /db_xref="PDB:5TH5" /db_xref="SubtiList:BG13314" /db_xref="UniProtKB/Swiss-Prot:O31677" /translation="MAKGIPVLEIFGPTIQGEGMVIGQKTMFVRTAGCDYSCSWCDSA FTWDGSAKKDIRWMTAEEIFAELKDIGGDAFSHVTISGGNPALLKQLDAFIELLKENN IRAALETQGTVYQDWFTLIDDLTISPKPPSSKMVTNFQKLDHILTSLQENDRQHAVSL KVVIFNDEDLEFAKTVHKRYPGIPFYLQVGNDDVHTTDDQSLIAHLLGKYEALVDKVA VDAELNLVRVLPQLHTLLWGNKRGV*" /label="queE CDS" gene 1327518..1328249 /gene="queE" /locus_tag="BSU_13740" /old_locus_tag="BSU13740" /label="queE gene" CDS 1328267..1328764 /gene="queF" /locus_tag="BSU_13750" /old_locus_tag="BSU13750" /EC_number="1.7.1.13" /function="10.3: tRNA and rRNA base modification" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 17929836, 22938038, 23410922, 28300774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 17929836, 22938038, 23410922, 28300774; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent 7-cyano-7-deazaguanine reductase" /protein_id="NP_389258.1" /db_xref="EnsemblGenomes-Gn:BSU13750" /db_xref="EnsemblGenomes-Tr:CAB13248" /db_xref="GOA:O31678" /db_xref="InterPro:IPR016856" /db_xref="InterPro:IPR029500" /db_xref="PDB:4F8B" /db_xref="PDB:4FGC" /db_xref="PDB:5UDG" /db_xref="SubtiList:BG13315" /db_xref="UniProtKB/Swiss-Prot:O31678" /translation="MTTRKESELEGVTLLGNQGTNYLFEYAPDVLESFPNKHVNRDYF VKFNCPEFTSLCPKTGQPDFATIYISYIPDEKMVESKSLKLYLFSFRNHGDFHEDCMN IIMNDLIELMDPRYIEVWGKFTPRGGISIDPYTNYGKPGTKYEKMAEYRMMNHDLYPE TIDNR*" /label="queF CDS" gene 1328267..1328764 /gene="queF" /locus_tag="BSU_13750" /old_locus_tag="BSU13750" /label="queF gene" S_feature 1328765..1329041 /Source="Nicolas_S_feature" /locus_tag="new_1441789_1442065" /HighExp="Paraq, ferm, LPhT, C30, G135, G180, LBGstat, Oxctl, G150, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S495" downshifts 1328999 /Source="Nicolas_upshifts" /id="D760" /incds=0 /nref=200 /ntot=247 /MaxReadThrough="1.17154" /MaxDrop="6.60953" /score="11.1883045" /energy="-7.8" /TU="NA" /idTUdmin="U1114" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1329009) /Source="Nicolas_upshifts" /id="D761" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.54726" /MaxDrop="2.16508" /score="6.24357423" /energy="-7.6" /TU="NA" /idTUdmin="U1115" /TUdmin=110 /isTUend="FALSE" /label="downshifts" S_feature complement(1329078..1329322) /Source="Nicolas_S_feature" /locus_tag="new_1442102_1442346_c" /HighExp="Diami, dia5, LPhT, Etha, Salt, dia15, Heat, HiTm, C30, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15795400000000001" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S496" downshifts complement(1329119) /Source="Nicolas_upshifts" /id="D762" /incds=0 /nref=47 /ntot=193 /MaxReadThrough="2.13712" /MaxDrop="5.08206" /score="6.24357423" /energy="-7.6" /TU="NA" /idTUdmin="U1115" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1329323..1329679) /gene="ykvN" /locus_tag="BSU_13760" /old_locus_tag="BSU13760" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (HGT island)" /protein_id="NP_389259.1" /db_xref="EnsemblGenomes-Gn:BSU13760" /db_xref="EnsemblGenomes-Tr:CAB13249" /db_xref="GOA:O31679" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13316" /db_xref="UniProtKB/Swiss-Prot:O31679" /translation="MKKFSCGFEVTKEVIGGKWKGLVLYFLMNGPKRTSELKRIIPNI TQKMLIQTLRELEASGLVSRKMYNQVPPKVEYSSTELGESLKPILQELCQWGGYYAEQ EYAEGEYEIVQPEQLS*" /label="ykvN CDS" gene complement(1329323..1329679) /gene="ykvN" /locus_tag="BSU_13760" /old_locus_tag="BSU13760" /label="ykvN gene" misc_feature complement(1329710..1329729) /Source="Nicolas_upshift_promotors" /id="U1115" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.727272727272727" /psig="0.997002997002997" /xcortree=1897 /SigmaFactorBS="acaacttacaagatatagtatccttcagtaagcacattatcg gaagtacccactttttTGTGATATAGTAACTAAAAAgtaataaatgtggaatggagag c" /listShort="ykvN, S496" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1329727) /Source="Nicolas_upshifts" /id="U1115" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.727272727272727" /psig="0.997002997002997" /xcortree=1897 /SigmaFactorBS="acaacttacaagatatagtatccttcagtaagcacattatcg gaagtacccactttttTGTGATATAGTAACTAAAAAgtaataaatgtggaatggagag c" /listShort="ykvN, S496" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1329764..1329782 /Source="Nicolas_upshift_promotors" /id="U1116" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.313686313686314" /psig="0.954045954045954" /xcortree=1793 /SigmaFactorBS="ctttttagttactatatcacaaaaaagtgggtacttCcgata atgtgcttactgaAGGATACTATATCTTGTAAgttgttcttcaagtacttaaaggtac t" /listShort="ykvO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1329769 /Source="Nicolas_upshifts" /id="U1116" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.313686313686314" /psig="0.954045954045954" /xcortree=1793 /SigmaFactorBS="ctttttagttactatatcacaaaaaagtgggtacttCcgata atgtgcttactgaAGGATACTATATCTTGTAAgttgttcttcaagtacttaaaggtac t" /listShort="ykvO" /GFF_Attribute="listLong" /label="upshifts" CDS 1329848..1330594 /gene="ykvO" /locus_tag="BSU_13770" /old_locus_tag="BSU13770" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018, 26494135; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (HGT island)" /protein_id="NP_389260.1" /db_xref="EnsemblGenomes-Gn:BSU13770" /db_xref="EnsemblGenomes-Tr:CAB13250" /db_xref="GOA:O31680" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13317" /db_xref="UniProtKB/Swiss-Prot:O31680" /translation="MGKFEGKIALVTGGTSGIGLATAQKFVNEGAYVYITGRRQNELD KAVNQIGKNVTGVQGDISKLEDLDKLYDIIKQEKGKLDILFANAGIGNFLPLGEITEE QVDRTFDINVKGTIFTVQKALSLFPDKVGSIIVTGSTAGSIGNPAFSVYGASKAALRA LVRNWILDLKGTEIRVNVVSPGGILTPAYDELFGDALEEVLENSRNTVPAGKVGTPEE VANAVSFLASDESSYLTGVELFVDGGLAQV*" /label="ykvO CDS" gene 1329848..1330594 /gene="ykvO" /locus_tag="BSU_13770" /old_locus_tag="BSU13770" /label="ykvO gene" downshifts 1330649 /Source="Nicolas_upshifts" /id="D763" /incds=0 /nref=19 /ntot=146 /MaxReadThrough="0.723690000000001" /MaxDrop="4.37163" /score="1.34631843" /energy="-9.1" /TU="NA" /idTUdmin="U1116" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1330997..1331005 /Source="Nicolas_upshift_promotors" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1331019..1331038 /Source="Nicolas_upshift_promotors" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1331023 /Source="Nicolas_upshifts" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="upshifts" CDS 1331075..1332274 /gene="ykvP" /locus_tag="BSU_13780" /old_locus_tag="BSU13780" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11011148, 16683018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11011148, 16683018; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore protein (HGT island)" /protein_id="NP_389261.1" /db_xref="EnsemblGenomes-Gn:BSU13780" /db_xref="EnsemblGenomes-Tr:CAB13251" /db_xref="GOA:O31681" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13318" /db_xref="UniProtKB/Swiss-Prot:O31681" /translation="MKILFLESHPMWLYGLPNGFREAGHTVMISGPVSRENITEMIDE FKPDLIVSMGWTPEHSREKQAWIRNATKKVNIPLVYWATEDPLHTQNFTIPLIKKMKP DFVFTVTPSLCKTYESMGIKAAHLDFAFHESIHHQIKPLAKYSCDIAVVANAYPNFLE EHPEVFRSSSLKTLIRPLIRKGIRIDFWGRNWEKMSKYIGREIPRNWIHGYLDYTEAY KVYSSAKIIIGLQNCESQLTQRTYEILGSGGFLLTSDTPAVRGKFKPGRDLIVSSSPK ETLEKVKYYLNHDSERKKIQINGKKAVKNDSYRHRAERMLEVLKSRGIIRNLGETIHY VDVLKEKYVIHHVTPGETLSIIASKYNVSLQQLMELNHFKSDQIYAGQIIKIREKLFR NINNKLF*" /label="ykvP CDS" gene 1331075..1332274 /gene="ykvP" /locus_tag="BSU_13780" /old_locus_tag="BSU13780" /label="ykvP gene" promotor_-35 1331157..1331163 /Source="Nicolas_upshift_promotors" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1331178..1331196 /Source="Nicolas_upshift_promotors" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1331184 /Source="Nicolas_upshifts" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1332243..1332245 /Source="Nicolas_upshift_promotors" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1332265..1332283 /Source="Nicolas_upshift_promotors" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1332277 /Source="Nicolas_upshifts" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1332290..1332517 /gene="ykzQ" /locus_tag="BSU_13789" /old_locus_tag="BSU13789" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative peptidoglycan binding protein" /protein_id="YP_003097719.1" /db_xref="EnsemblGenomes-Gn:BSU13789" /db_xref="EnsemblGenomes-Tr:CAX52610" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="UniProtKB/Swiss-Prot:C0H403" /translation="MKGKIPKIRNQANKVKRTPRYMEFPVTYEVYHVESGDTLWTIAK SFEIPVQQLMNLNKLSSDRIYPGQIIKIRER*" /label="ykzQ CDS" gene 1332290..1332517 /gene="ykzQ" /locus_tag="BSU_13789" /old_locus_tag="BSU13789" /label="ykzQ gene" misc_feature complement(1332367..1332386) /Source="Nicolas_upshift_promotors" /id="U1120" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig="0.982017982017982" /xcortree=2163 /SigmaFactorBS="ggaatttcaaaggatttggcaatcgtccataatgtatcgccg gattccaCATGATATACTTCGTATGTCacgggaaattccatataacgaggcgttcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1332375) /Source="Nicolas_upshifts" /id="U1120" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig="0.982017982017982" /xcortree=2163 /SigmaFactorBS="ggaatttcaaaggatttggcaatcgtccataatgtatcgccg gattccaCATGATATACTTCGTATGTCacgggaaattccatataacgaggcgttcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1332518..1332613 /Source="Nicolas_S_feature" /locus_tag="new_1445542_1445637" /HighExp="BT, S8, B36, S7, Etha, S6, G/S, LBGstat, Pyr, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigK" /TUshortPSig="0.602, 0.999, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S497" CDS 1332614..1333312 /gene="ykvQ" /locus_tag="BSU_13790" /old_locus_tag="BSU13790" /EC_number="3.2.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative sporulation-specific glycosylase (HGT island)" /db_xref="EnsemblGenomes-Gn:BSU13790" /db_xref="EnsemblGenomes-Tr:CAB13252" /db_xref="GOA:O31682" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="PSEUDO:CAB13252.1" /db_xref="SubtiList:BG13319" /db_xref="UniProtKB/Swiss-Prot:O31682" /translation="MFQMSYYYSGLGWDFIQHVDQTNGVLNVVSPDFFYIRKDGSLLL RSANPDVIKALHRRKLKVVPFLSNHWDQDLGRFALMNRVLLAKQISHAIEELDLDGVN IDIENLTEKDRNLFTDFIRLVRKSIPRHKEVSVAVAANPFGWTKGWHGSYDYEYLAKY ADYLMVMAYDESRLAGPTASVGWVEKSIQYVLTQKISPQKLVLGLPFYGRCWMEGQSA SQAIPLYLVVSKKA*" /label="ykvQ CDS" gene 1332614..1333312 /gene="ykvQ" /locus_tag="BSU_13790" /old_locus_tag="BSU13790" /pseudo /label="ykvQ gene" S_feature complement(1333265..1334091) /Source="Nicolas_S_feature" /locus_tag="new_1446289_1447115_c" /HighExp="H2O2, M40t90, S8, M40t45, LPhT, Sw, Cold, LBGstat, C30, dia15" /AntisenseName="ykzR" /AntisenseCor="0.170402182980955" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="0.38670900000000002" /TUshortSig="SigA" /TUshortPSig="0.986" /TUlongSig="NA" /TUlongPSig="NA" /label="S498" CDS 1333293..1333544 /gene="ykzR" /locus_tag="BSU_13799" /old_locus_tag="BSU13799" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative spore-specific glycosyl hydrolase" /db_xref="EnsemblGenomes-Gn:BSU13799" /db_xref="EnsemblGenomes-Tr:CAX52611" /db_xref="GOA:C0H404" /db_xref="InterPro:IPR017853" /db_xref="PSEUDO:CAX52611.1" /db_xref="UniProtKB/Swiss-Prot:C0H404" /translation="MLVKRHSGTIIFDTKSQSPKAIFTVNHDKKGPLPSGTYTLWFEN EQSLRAKIKLAQKYNLKGLGSWSLGQEDASVWNTVFKNI*" /label="ykzR CDS" gene 1333293..1333544 /gene="ykzR" /locus_tag="BSU_13799" /old_locus_tag="BSU13799" /pseudo /label="ykzR gene" misc_feature 1333794..1333809 /Source="Nicolas_upshift_promotors" /id="U1121" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=2456 /SigmaFactorBS="ctgcttccatgatttaatcatacacatgctacttgatAGCAG GGTTATCGCATttcattcagaattgttcaggatcgatatggaagcgcacgactaacta g" /listShort="S499" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1333817..1334028 /Source="Nicolas_S_feature" /locus_tag="new_1446841_1447052" /HighExp="Diami, S8, dia15, G180, HPh, C30, Paraq, H2O2, Salt, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.516" /TUlongSig="NA" /TUlongPSig="NA" /label="S499" upshifts 1333817 /Source="Nicolas_upshifts" /id="U1121" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=2456 /SigmaFactorBS="ctgcttccatgatttaatcatacacatgctacttgatAGCAG GGTTATCGCATttcattcagaattgttcaggatcgatatggaagcgcacgactaacta g" /listShort="S499" /GFF_Attribute="listLong" /label="upshifts" downshifts 1333993 /Source="Nicolas_upshifts" /id="D764" /incds=0 /nref=2 /ntot=72 /MaxReadThrough="2.59168" /MaxDrop="2.74537" /score="-4.38958816" /energy="-9" /TU="NA" /idTUdmin="U1121" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1334080..1334099) /Source="Nicolas_upshift_promotors" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1334102) /Source="Nicolas_upshifts" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1334115..1334122) /Source="Nicolas_upshift_promotors" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1334167..1334174 /Source="Nicolas_upshift_promotors" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1334189..1334208 /Source="Nicolas_upshift_promotors" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1334191 /Source="Nicolas_upshifts" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="upshifts" CDS 1334227..1334517 /gene="ykvR" /locus_tag="BSU_13800" /old_locus_tag="BSU13800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (HGT island)" /protein_id="NP_389263.1" /db_xref="EnsemblGenomes-Gn:BSU13800" /db_xref="EnsemblGenomes-Tr:CAB13253" /db_xref="InterPro:IPR021596" /db_xref="InterPro:IPR023105" /db_xref="PDB:2JN9" /db_xref="SubtiList:BG13320" /db_xref="UniProtKB/Swiss-Prot:O31683" /translation="MKTLRLNNVTLEMAAYQEESEPKRKIAFTLNVTSETYHDIAVLL YEKTFNVEVPERDLAFRGEMTNYSTSLTNLYEPGAVSEFYIEITEIDKNADS*" /label="ykvR CDS" gene 1334227..1334517 /gene="ykvR" /locus_tag="BSU_13800" /old_locus_tag="BSU13800" /label="ykvR gene" S_feature complement(1334554..1334637) /Source="Nicolas_S_feature" /locus_tag="new_1447578_1447661_c" /HighExp="Etha, dia5, Salt, SMMPr, Lbtran, dia15, Heat, S4, HiOs, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S500" downshifts complement(1334597) /Source="Nicolas_upshifts" /id="D765" /incds=0 /nref=216 /ntot=257 /MaxReadThrough="2.80569" /MaxDrop="6.83857" /score="21.3524751" /energy="-9.9" /TU="U1124" /idTUdmin="U1126" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1334638..1334823) /gene="ykvS" /locus_tag="BSU_13810" /old_locus_tag="BSU13810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (HGT island)" /protein_id="NP_389264.2" /db_xref="EnsemblGenomes-Gn:BSU13810" /db_xref="EnsemblGenomes-Tr:CAB13254" /db_xref="InterPro:IPR018690" /db_xref="SubtiList:BG13321" /db_xref="UniProtKB/Swiss-Prot:O31684" /translation="MKIAKVGNVIEFKNGLTGVVEKVNENSVIVDVTIMDNYRDLELD SLTVVNHKNYKIIRDSY*" /label="ykvS CDS" gene complement(1334638..1334823) /gene="ykvS" /locus_tag="BSU_13810" /old_locus_tag="BSU13810" /label="ykvS gene" promotor_-10 complement(1334856..1334875) /Source="Nicolas_upshift_promotors" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1334867) /Source="Nicolas_upshifts" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1334869..1335213) /Source="Nicolas_S_feature" /locus_tag="new_1447893_1448237_c" /HighExp="S4, S8, S6, S5, S3, T5.0H, LoTm, S7, T4.0H, BT" /AntisenseName="ykzS" /AntisenseCor="-0.65556958045860303" /AntisenseRegPval="-33.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S501" promotor_-35 complement(1334889..1334896) /Source="Nicolas_upshift_promotors" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1334922..1334927 /Source="Nicolas_upshift_promotors" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1334943..1334962 /Source="Nicolas_upshift_promotors" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1334950 /Source="Nicolas_upshifts" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="upshifts" CDS 1334989..1335183 /gene="ykzS" /locus_tag="BSU_13819" /old_locus_tag="BSU13819" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (HGT island)" /protein_id="YP_003097721.1" /db_xref="EnsemblGenomes-Gn:BSU13819" /db_xref="EnsemblGenomes-Tr:CAX52612" /db_xref="UniProtKB/Swiss-Prot:C0H405" /translation="MRPEEITEMIEQLRTGAINELRVQKEHFLDFRAVLSKQDDFKHF RGIAQQGGDVIFQYLEQPRS*" /label="ykzS CDS" gene 1334989..1335183 /gene="ykzS" /locus_tag="BSU_13819" /old_locus_tag="BSU13819" /label="ykzS gene" downshifts 1335159 /Source="Nicolas_upshifts" /id="D766" /incds=0 /nref=6 /ntot=124 /MaxReadThrough="3.66738" /MaxDrop="3.03929" /score="5.82604583" /energy="-10.6" /TU="U1125" /idTUdmin="U1123" /TUdmin=682 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1335204..1335222) /Source="Nicolas_upshift_promotors" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1335220) /Source="Nicolas_upshifts" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1335239..1335244) /Source="Nicolas_upshift_promotors" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1335482..1336108 /gene="ykvT" /locus_tag="BSU_13820" /old_locus_tag="BSU13820" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12177332, 12950927, 23199363; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cell wall hydrolase related to spore cortex-lytic enzymes" /protein_id="NP_389265.1" /db_xref="EnsemblGenomes-Gn:BSU13820" /db_xref="EnsemblGenomes-Tr:CAB13255" /db_xref="GOA:O31685" /db_xref="InterPro:IPR011105" /db_xref="SubtiList:BG13322" /db_xref="UniProtKB/Swiss-Prot:O31685" /translation="MTTKFTALAVFLLCFMPAAKIEHTQASLLSAKKTKHEEAKWLTH IDRNTNESFPSLSADKDKKIKPIKLSAHTEKKEKDKPDKTNDEKETYTQSEKELLSRL VHAEAKGESYKGKVAVASVVLNRTEKKGFPDTIRGVIYQKNAFEPVANGSINQKPDKE SIEAAEEALSSKNRETDAIFFYNPKTASDNWIRSRKIVEKIGRHVFAV*" /label="ykvT CDS" gene 1335482..1336108 /gene="ykvT" /locus_tag="BSU_13820" /old_locus_tag="BSU13820" /label="ykvT gene" downshifts 1336039 /Source="Nicolas_upshifts" /id="D767" /incds=1 /nref=1 /ntot=17 /MaxReadThrough="0.932830000000001" /MaxDrop="1.92264" /score="9.80914166" /energy="-11.9" /TU="NA" /idTUdmin="U1125" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 1336165..1336170 /Source="Nicolas_upshift_promotors" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1336177 /Source="Nicolas_upshifts" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1336186..1336204 /Source="Nicolas_upshift_promotors" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1336226..1337563 /gene="ykvU" /locus_tag="BSU_13830" /old_locus_tag="BSU13830" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15686839, 15849754, 16850406, 19648239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15686839, 15849754, 16850406, 19648239; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="spore membrane protein involved in germination" /protein_id="NP_389266.1" /db_xref="EnsemblGenomes-Gn:BSU13830" /db_xref="EnsemblGenomes-Tr:CAB13256" /db_xref="GOA:O31686" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="SubtiList:BG13323" /db_xref="UniProtKB/Swiss-Prot:O31686" /translation="MNRFVKGIILLSIAAFFAECLEFVVNMILARELGEHGMGLYMSI LPTIFLIIVIASLELPISISKFIAESNPKLHESMLRHAFRMTAIFTAFSTAAASIALP FIPVFDTYHPFIKGIVIGLIPVVAFTSIARGYFMGVQKMGKIAIANVLKKIIQLLCLF LFFQWYSFELDMAVLISLFVLVVSDVVVLVYLYSQFIMARRALSGQQHIHLRGKDVRK RLLAVSIPTTGLRIFHAVVNAIEPFLVKGALLAAGVAGTAAIDQYGMLAGVAVTIGSF PAFIAHSLMVVMIPSISEAYALSQYDIVLKRLKQSIFITLGYGIPAVWVMFQFAGPLT HLFFHSPEAQYYLQLLWPYFLFHLFVMPLQACLIGMGFVKEAFYHNVWSHIVALSMMY VLGSMENLQMLGIILGMNTGMILLTSLHYATICKALKVSVFLTGGTRTPRIEG*" /label="ykvU CDS" gene 1336226..1337563 /gene="ykvU" /locus_tag="BSU_13830" /old_locus_tag="BSU13830" /label="ykvU gene" CDS 1337614..1338111 /gene="stoA" /locus_tag="BSU_13840" /old_locus_tag="BSU13840" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15292147, 15322369, 15342593, 19144642, 28383125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15292147, 15322369, 15342593, 19144642, 28383125; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore-specific thiol-disulfide oxidoreductase (SpoVD maturation)" /protein_id="NP_389267.1" /db_xref="EnsemblGenomes-Gn:BSU13840" /db_xref="EnsemblGenomes-Tr:CAB13257" /db_xref="GOA:O31687" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR036249" /db_xref="PDB:3ERW" /db_xref="SubtiList:BG13324" /db_xref="UniProtKB/Swiss-Prot:O31687" /translation="MLTKRLLTIYIMLLGLIAWFPGAAQAEEKQPAVPAVFLMKTIEG EDISIPNKGQKTILHFWTSWCPPCKKELPQFQSFYDAHPSDSVKLVTVNLVNSEQNQQ VVEDFIKANKLTFPIVLDSKGELMKEYHIITIPTSFLLNEKGEIEKTKIGPMTAEQLK EWTEE*" /label="stoA CDS" gene 1337614..1338111 /gene="stoA" /locus_tag="BSU_13840" /old_locus_tag="BSU13840" /label="stoA gene" promotor_-35 1337960..1337966 /Source="Nicolas_upshift_promotors" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1337975 /Source="Nicolas_upshifts" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1337981..1337999 /Source="Nicolas_upshift_promotors" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1338085 /Source="Nicolas_upshifts" /id="D768" /incds=0 /nref=36 /ntot=164 /MaxReadThrough="1.89069" /MaxDrop="4.34947" /score="14.1388498" /energy="-11.3" /TU="NA" /idTUdmin="U1127" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1338206..1338212 /Source="Nicolas_upshift_promotors" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1338223..1338242 /Source="Nicolas_upshift_promotors" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1338235 /Source="Nicolas_upshifts" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1338239..1338346 /Source="Nicolas_S_feature" /locus_tag="new_1451263_1451370" /HighExp="LBGstat, C90, Lbstat, BC, Cold, T0.30H, Etha, Lbtran, LBGtran, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S502" CDS 1338347..1340260 /gene="pfeT" /locus_tag="BSU_13850" /old_locus_tag="BSU13850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12029044, 12180919, 15802251, 21813502, 26261021, 26566138" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12180919, 15802251, 21813502, 26261021, 26566138; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Fe(II) efflux transporter possibly involved in copper(II) uptake" /protein_id="NP_389268.1" /db_xref="EnsemblGenomes-Gn:BSU13850" /db_xref="EnsemblGenomes-Tr:CAB13258" /db_xref="GOA:O31688" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG13325" /db_xref="UniProtKB/Swiss-Prot:O31688" /translation="MNEQVIVQRDPHEPLKTDKREKNWAQHAELIAALVSGALILAGW LLSGYQVLSIILFLLAFVIGGFAKAKEGIEETLESKTLNVELLMIFAAIGSALIGYWA EGAILIFIFSLSGALETYTMNKSSRDLTSLMQLEPEEATLMVNGETKRVPVSDLQAGD MIVIKPGERVAADGIIESGSTSLDESALTGESMPVEKNTGDTVFTGTVNRNGSLTVRV TKANEDSLFRKIIKLVESAQNSVSPAQAFIERFENAYVKGVLIAVALLLFVPHFALGW SWSETFYRAMVFMVVASPCALVASIMPAALSLISNGARNGMLVKGSVFLEQLGSVQMI AFDKTGTVTKGQPAVETIRIAEGFSEAEVLEAVYAIETQSSHPLAQAITAYAESRGVN QSGYISIEETSGFGVMAEVSGAKWKVGKAGFIGEEMAAQFMKQTASDVIQSGHTIVFV KKDDQIAGCIALKDQIRPEAKEVMEELNRLGIKTAMLTGDHEDTAQAIAKEAGMTTVV AECLPDQKVNEIKRLKEEFGTIAMVGDGINDAPALKAADVGIAMGGGTDVALETADMV LMKNDLKKLVNMCRLSRKMNRIIKQNIVFSLAVICLLICANFLQAMELPFGVIGHEGS TILVILNGLRLLK*" /label="pfeT CDS" gene 1338347..1340260 /gene="pfeT" /locus_tag="BSU_13850" /old_locus_tag="BSU13850" /label="pfeT gene" promotor_-10 complement(1338496..1338515) /Source="Nicolas_upshift_promotors" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1338513) /Source="Nicolas_upshifts" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1338528..1338537) /Source="Nicolas_upshift_promotors" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1338664..1338683) /Source="Nicolas_upshift_promotors" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1338689) /Source="Nicolas_upshifts" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1338697..1338703) /Source="Nicolas_upshift_promotors" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1340241 /Source="Nicolas_upshifts" /id="D769" /incds=0 /nref=62 /ntot=148 /MaxReadThrough="2.05978" /MaxDrop="6.90668" /score="30.2111295" /energy="-18" /TU="NA" /idTUdmin="U1129" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1340317) /Source="Nicolas_upshifts" /id="D770" /incds=0 /nref=74 /ntot=208 /MaxReadThrough="0.83751" /MaxDrop="4.23141" /score="34.2342147" /energy="-18" /TU="NA" /idTUdmin="U1132" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1340528..1340547) /Source="Nicolas_upshift_promotors" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1340537) /Source="Nicolas_upshifts" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1340561..1340568) /Source="Nicolas_upshift_promotors" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1340612..1340631 /Source="Nicolas_upshift_promotors" /id="U1133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.434565434565435" /psig=1 /xcortree=1996 /SigmaFactorBS="taaaatgcattagaaaatgaaggcgtcgtgaaaggcaaacac cggtaaaaCCTGTTACAATGGAAGACAGaacaatgcattgcaaatggcagggaggaac a" /listShort="ykvY, S504, ykvZ, glcT, S505, ptsG, ptsH, ptsI" /listLong="splA, splB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1340622 /Source="Nicolas_upshifts" /id="U1133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.434565434565435" /psig=1 /xcortree=1996 /SigmaFactorBS="taaaatgcattagaaaatgaaggcgtcgtgaaaggcaaacac cggtaaaaCCTGTTACAATGGAAGACAGaacaatgcattgcaaatggcagggaggaac a" /listShort="ykvY, S504, ykvZ, glcT, S505, ptsG, ptsH, ptsI" /listLong="splA, splB" /label="upshifts" CDS 1340667..1341758 /gene="papB" /locus_tag="BSU_13860" /old_locus_tag="BSU13860" /EC_number="3.4.13.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7770058, 23144141" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7770058, 23144141; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Xaa-Pro Xaa-Pro-Xaa di-tri-peptidase used in osmoprotection" /protein_id="NP_389269.1" /db_xref="EnsemblGenomes-Gn:BSU13860" /db_xref="EnsemblGenomes-Tr:CAB13259" /db_xref="GOA:O31689" /db_xref="InterPro:IPR000587" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001131" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR029149" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG13326" /db_xref="UniProtKB/Swiss-Prot:O31689" /translation="MNRIQRVSSWLKEAGHTAAFIHTKENVFYLTGFYTEPHERLMGL FIFQEEEPFFVCPGMEAGQARNAGWNHEIIGYADHENPWELIEKALKKRNISIHMLAV EKDSISLSRAEQLKHATGGAQFVSAEETLNQFRLIKDDNEIRLLKEAAKLADYGVEVG TAALREGISEVEVLAQIEYELKKKGIQGMSFSTMVLFGEKSGQPHGNPGTATLKKGDF VLFDLGVILDGYCSDITRTFAYKTINPKQEAIYETVLQAEKAAIEASKPGVRIGDLDL TARGIIEKAGYGDYFPHRLGHGLGISVHEYPSMSQANDTLLQEGMVYTIEPGIYVPEI GGVRIEDDVHVTKDGAVALTQYPKDLIIL*" /label="papB CDS" gene 1340667..1341758 /gene="papB" /locus_tag="BSU_13860" /old_locus_tag="BSU13860" /label="papB gene" downshifts 1341407 /Source="Nicolas_upshifts" /id="D771" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.10599" /MaxDrop="5.06339" /score="-5.18621526" /energy="-6.2" /TU="U1133" /idTUdmin="U1129" /TUdmin=1166 /isTUend="FALSE" /label="downshifts" downshifts 1341737 /Source="Nicolas_upshifts" /id="D772" /incds=0 /nref=2 /ntot=52 /MaxReadThrough="5.66039" /MaxDrop="2.56719" /score="-5.18621526" /energy="-6.2" /TU="U1133" /idTUdmin="U1129" /TUdmin=1496 /isTUend="FALSE" /label="downshifts" S_feature complement(1341771..1341989) /Source="Nicolas_S_feature" /locus_tag="new_1454795_1455013_c" /HighExp="B60, B36, C30, G135, LBGstat, S8, Lbstat, C90, Etha, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.92748200000000003" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S503" S_feature 1341782..1342039 /Source="Nicolas_S_feature" /locus_tag="new_1454806_1455063" /HighExp="dia15, dia5, Etha, M0t90, M40t90, Lbstat, H2O2, G150, Mt0, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S504" promotor_-10 complement(1341976..1341995) /Source="Nicolas_upshift_promotors" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1341989) /Source="Nicolas_upshifts" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1342011..1342018) /Source="Nicolas_upshift_promotors" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1342040..1343005 /gene="ykvZ" /locus_tag="BSU_13870" /old_locus_tag="BSU13870" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LacI family)" /protein_id="NP_389270.1" /db_xref="EnsemblGenomes-Gn:BSU13870" /db_xref="EnsemblGenomes-Tr:CAB13260" /db_xref="GOA:O31690" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR001761" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13327" /db_xref="UniProtKB/Swiss-Prot:O31690" /translation="MANIKDIAEKAGVSVTTVSRVINNHPYVSEDKRKRVFEAMESLE YTRNIHAVHLSKGFSNMIGVVLPTVNLPYFAELIAGIADAAAESGVHLSLFQTNYEVQ KEIFALSQLKQRQVDGLIFCSKALADEKLMEWEGPILLCQNSDNARFPTISIPHQEAF RNGLDYLIAKGHKKIAICLARKKGMNSHFRIKAYKEALEEIGEAFREDWVIEKAITIN DGKALFHKWNTWKEKPTAIFVANDQVSAGLFLEAKNQRVSVPDELAILSVDNHEISQA LGITTIDIQTREMGKQAFAILEKRIQGQPIERKVLDYRLIERSTV*" /label="ykvZ CDS" gene 1342040..1343005 /gene="ykvZ" /locus_tag="BSU_13870" /old_locus_tag="BSU13870" /label="ykvZ gene" promotor_-35 1343023..1343030 /Source="Nicolas_upshift_promotors" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="promotor_-35" promotor_-10 1343045..1343064 /Source="Nicolas_upshift_promotors" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="promotor_-10" upshifts 1343057 /Source="Nicolas_upshifts" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="upshifts" CDS 1343068..1343934 /gene="glcT" /locus_tag="BSU_13880" /old_locus_tag="BSU13880" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10974121, 14527945, 15155854, 17074746, 22750856" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10974121, 14527945, 15155854, 17074746, 22750856; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator (BglG family)" /protein_id="NP_389271.2" /db_xref="EnsemblGenomes-Gn:BSU13880" /db_xref="EnsemblGenomes-Tr:CAB13261" /db_xref="GOA:O31691" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:3GWH" /db_xref="PDB:3RIO" /db_xref="PDB:3UFE" /db_xref="SubtiList:BG12593" /db_xref="UniProtKB/Swiss-Prot:O31691" /translation="MTKELRIVNGSFTVKKVLNNNVLIASHHKYSEVVLIGKGIGFGK KQDDVIEDKGYDKMFILKDEKEQKQFKKLLDYVDEKLVDISNDVIYHISNRTNHSLNE HIHIALTDHIAFAIKRQQQGFDMKNPFLMETQSLYPEEYQIAKEVIDMINEKAGLCLP EGEIGFIALHIHSALTNRPLSEVNQHSQLMAQLVEVIEDSFQMKVNKESVNYLRLIRH IRFTIERIKKEEPTKEPEKLMLLLKNEYPLCYNTAWKLIKILQQTLKKPVHEAEAVYL TLHLYRLTNKIS*" /label="glcT CDS" gene 1343068..1343934 /gene="glcT" /locus_tag="BSU_13880" /old_locus_tag="BSU13880" /label="glcT gene" promotor_-35 1343789..1343793 /Source="Nicolas_upshift_promotors" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1343810..1343829 /Source="Nicolas_upshift_promotors" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1343818 /Source="Nicolas_upshifts" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="upshifts" downshifts 1343936 /Source="Nicolas_upshifts" /id="D773" /incds=0 /nref=1 /ntot=30 /MaxReadThrough="9.01653" /MaxDrop="3.09921" /score="-5.18621526" /energy="-6.2" /TU="U1133,U1135,U1136" /idTUdmin="U1135" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" misc_RNA 1343981..1344132 /gene="gswA" /locus_tag="BSU_misc_RNA_88" /product="riboswitch regulating ptsGHI expression via GlcTbinding" /experiment="publication(s) with functional evidences, PMID:15155854, 22750856" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15155854, 22750856; Product type n: RNA" /label="gswA RNA" S_feature 1343981..1344132 /Source="Nicolas_S_feature" /locus_tag="new_1457005_1457156" /HighExp="LBGexp, G150, C30, G135, G180, MG 90, dia0, Lbexp, dia15, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.988, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S505" gene 1343981..1344132 /gene="gswA" /locus_tag="BSU_misc_RNA_88" /label="gswA gene" promotor_-35 1344110..1344116 /Source="Nicolas_upshift_promotors" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1344130..1344141 /Source="Nicolas_upshift_promotors" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1344134 /Source="Nicolas_upshifts" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="upshifts" CDS 1344163..1346262 /gene="ptsG" /locus_tag="BSU_13890" /old_locus_tag="BSU13890" /EC_number="2.7.1.199" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1447219, 8418852, 8432747, 9593197, 14527945, 15849754, 16850406, 22846916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1447219, 8418852, 8432747, 9593197, 14527945, 15849754, 16850406, 22846916; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) glucose-specificenzyme IICBA component" /protein_id="NP_389272.1" /db_xref="EnsemblGenomes-Gn:BSU13890" /db_xref="EnsemblGenomes-Tr:CAB13262" /db_xref="GOA:P20166" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011299" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="PDB:1AX3" /db_xref="PDB:1GPR" /db_xref="SubtiList:BG10198" /db_xref="UniProtKB/Swiss-Prot:P20166" /translation="MFKALFGVLQKIGRALMLPVAILPAAGILLAIGNAMQNKDMIQV LHFLSNDNVQLVAGVMESAGQIVFDNLPLLFAVGVAIGLANGDGVAGIAAIIGYLVMN VSMSAVLLANGTIPSDSVERAKFFTENHPAYVNMLGIPTLATGVFGGIIVGVLAALLF NRFYTIELPQYLGFFAGKRFVPIVTSISALILGLIMLVIWPPIQHGLNAFSTGLVEAN PTLAAFIFGVIERSLIPFGLHHIFYSPFWYEFFSYKSAAGEIIRGDQRIFMAQIKDGV QLTAGTFMTGKYPFMMFGLPAAALAIYHEAKPQNKKLVAGIMGSAALTSFLTGITEPL EFSFLFVAPVLFAIHCLFAGLSFMVMQLLNVKIGMTFSGGLIDYFLFGILPNRTAWWL VIPVGLGLAVIYYFGFRFAIRKFNLKTPGREDAAEETAAPGKTGEAGDLPYEILQAMG DQENIKHLDACITRLRVTVNDQKKVDKDRLKQLGASGVLEVGNNIQAIFGPRSDGLKT QMQDIIAGRKPRPEPKTSAQEEVGQQVEEVIAEPLQNEIGEEVFVSPITGEIHPITDV PDQVFSGKMMGDGFAILPSEGIVVSPVRGKILNVFPTKHAIGLQSDGGREILIHFGID TVSLKGEGFTSFVSEGDRVEPGQKLLEVDLDAVKPNVPSLMTPIVFTNLAEGETVSIK ASGSVNREQEDIVKIEK*" /label="ptsG CDS" gene 1344163..1346262 /gene="ptsG" /locus_tag="BSU_13890" /old_locus_tag="BSU13890" /label="ptsG gene" promotor_-35 1346280..1346284 /Source="Nicolas_upshift_promotors" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1346300..1346319 /Source="Nicolas_upshift_promotors" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1346311 /Source="Nicolas_upshifts" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="upshifts" CDS 1346360..1346626 /gene="ptsH" /locus_tag="BSU_13900" /old_locus_tag="BSU13900" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10217795, 12411438, 14527945, 15126459, 16267306, 17085448, 17142398, 17726680, 20487301, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217795, 12411438, 14527945, 15126459, 16267306, 17085448, 17142398, 17726680, 20487301, 25355936; Product type f: factor" /codon_start=1 /transl_table=11 /product="histidine-containing phosphocarrier protein of the phosphotransferase system (PTS) (HPr protein)" /protein_id="NP_389273.1" /db_xref="EnsemblGenomes-Gn:BSU13900" /db_xref="EnsemblGenomes-Tr:CAB13263" /db_xref="GOA:P08877" /db_xref="InterPro:IPR000032" /db_xref="InterPro:IPR001020" /db_xref="InterPro:IPR002114" /db_xref="InterPro:IPR035895" /db_xref="PDB:1JEM" /db_xref="PDB:1KKL" /db_xref="PDB:1KKM" /db_xref="PDB:1SPH" /db_xref="PDB:2FEP" /db_xref="PDB:2HID" /db_xref="PDB:2HPR" /db_xref="PDB:3OQM" /db_xref="PDB:3OQN" /db_xref="PDB:3OQO" /db_xref="SubtiList:BG10200" /db_xref="UniProtKB/Swiss-Prot:P08877" /translation="MAQKTFKVTADSGIHARPATVLVQTASKYDADVNLEYNGKTVNL KSIMGVMSLGIAKGAEITISASGADENDALNALEETMKSEGLGE*" /label="ptsH CDS" gene 1346360..1346626 /gene="ptsH" /locus_tag="BSU_13900" /old_locus_tag="BSU13900" /label="ptsH gene" CDS 1346626..1348338 /gene="ptsI" /locus_tag="BSU_13910" /old_locus_tag="BSU13910" /EC_number="2.7.3.9" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3106335, 11902727, 15155854, 15670601, 25355936, 26159071" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3106335, 11902727, 15155854, 15670601, 25355936, 26159071; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) enzyme I" /protein_id="NP_389274.2" /db_xref="EnsemblGenomes-Gn:BSU13910" /db_xref="EnsemblGenomes-Tr:CAB13264" /db_xref="GOA:P08838" /db_xref="InterPro:IPR000121" /db_xref="InterPro:IPR006318" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR008731" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018274" /db_xref="InterPro:IPR023151" /db_xref="InterPro:IPR024692" /db_xref="InterPro:IPR036618" /db_xref="SubtiList:BG10201" /db_xref="UniProtKB/Swiss-Prot:P08838" /translation="MQELKGIGASAGIAIAKAYRLEEPDLTVEKKNISDSEAEVSRFD EAIARSKEELEKIKEHALKELGQDKADIFSAHLLVLSDPELLNPVKEKISTDSVNAEF ALKETSSMFVTMFESMDNEYMKERAADIRDVTKRVTGHLLGVEIPNPSMISEEVIIVA EDLTPSDTAQLNREFVKGFTTDIGGRTSHSAIMARSLEIPAVVGTKAATGTIQNGVTV IVDGINGDVIIDPSAETVKEYEEKHNAYLAQKAEWAKLVNEPTVSKDGHHVELAANIG TPDDVKGVLENGGEAVGLYRTEFLYMGRDQLPTEDEQFDAYKTVLERMEGKSVVVRTL DIGGDKELPYLQLPKEMNPFLGYRAIRLCLEEQEIFRTQLRALLRASTYGNLKIMFPM IATVNEFKEAKAILLEEKEKLVKAGQAVSDDIEVGMMVEIPSTAVIADQFAKEVDFFS IGTNDLIQYTMAADRMNERVSYLYQPYNPAILRLITLVIEAAHKEGKWVGMCGEMAGD EIAIPILLGLGLDEFSMSATSILPARTQISKLSKQEAESFKEKILSMSTTEEVVAFVK ETFK*" /label="ptsI CDS" gene 1346626..1348338 /gene="ptsI" /locus_tag="BSU_13910" /old_locus_tag="BSU13910" /label="ptsI gene" downshifts 1348325 /Source="Nicolas_upshifts" /id="D774" /incds=0 /nref=116 /ntot=277 /MaxReadThrough="5.0255" /MaxDrop="5.64321" /score="21.2608168" /energy="-12.3" /TU="U1136,U1138" /idTUdmin="U1133" /TUdmin=11 /isTUend="TRUE" /label="downshifts" promotor_-35 1348378..1348384 /Source="Nicolas_upshift_promotors" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1348399..1348410 /Source="Nicolas_upshift_promotors" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1348402 /Source="Nicolas_upshifts" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="upshifts" CDS 1348429..1348668 /gene="splA" /locus_tag="BSU_13920" /old_locus_tag="BSU13920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9009064, 9323362, 10629212" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9009064, 9323362, 10629212; Product type r: regulator" /codon_start=1 /transl_table=11 /product="TRAP-like transcriptional negative regulator of spore photoproduct lyase" /protein_id="NP_389275.1" /db_xref="EnsemblGenomes-Gn:BSU13920" /db_xref="EnsemblGenomes-Tr:CAB13265" /db_xref="GOA:P37955" /db_xref="InterPro:IPR022608" /db_xref="SubtiList:BG10202" /db_xref="UniProtKB/Swiss-Prot:P37955" /translation="MSNQFNAGDTVYVIYRNPHAANVAHIKEAEIVHHPYHEGELSLF IYETYHPFAEDDAVFASYEEAKSLYKELFDIDPYE*" /label="splA CDS" gene 1348429..1348668 /gene="splA" /locus_tag="BSU_13920" /old_locus_tag="BSU13920" /label="splA gene" S_feature complement(1348449..1349788) /Source="Nicolas_S_feature" /locus_tag="new_1461473_1462812_c" /HighExp="T4.0H, T3.30H, T3.0H, S3, S1, T2.0H, T2.30H, S2, T5.0H, S4" /AntisenseName="splB" /AntisenseCor="-0.193138593783996" /AntisenseRegPval="-2.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S506" CDS 1348746..1349774 /gene="splB" /locus_tag="BSU_13930" /old_locus_tag="BSU13930" /EC_number="4.1.99.14" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9733691, 10629212, 11053385, 11470912, 16829680, 16829676, 17293412, 18055591, 22197590, 22961846, 23607538, 24598744, 28027411" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733691, 10629212, 11053385, 11470912, 16829680, 16829676, 17293412, 18055591, 22197590, 22961846, 23607538, 24598744, 28027411; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore photoproduct (thymine dimer) lyase" /protein_id="NP_389276.1" /db_xref="EnsemblGenomes-Gn:BSU13930" /db_xref="EnsemblGenomes-Tr:CAB13266" /db_xref="GOA:P37956" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023897" /db_xref="InterPro:IPR034560" /db_xref="SubtiList:BG10203" /db_xref="UniProtKB/Swiss-Prot:P37956" /translation="MQNPFVPQLVYIEPRALEYPLGQELQDKFENMGIEIRETTSHNQ VRNIPGKNHLQQYRNAKSTLVIGVRKTLKFDSSKPSAEYAIPFATGCMGHCHYCYLQT TMGSKPYIRTYVNVEEILDQADKYMKERAPEFTRFEASCTSDIVGIDHLTHTLKRAIE HFGQSDLGKLRFVTKFHHVDHLLDAKHNGKTRFRFSINADYVIKNFEPGTSPLDKRIE AAVKVAKAGYPLGFIVAPIYIHEGWEEGYRHLFEKLDAALPQDVRHDITFELIQHRFT KPAKRVIEKNYPKTKLELDEEKRRYKWGRYGIGKYIYQKDEEHALREALESYIDTFFP NAKIEYFT*" /label="splB CDS" gene 1348746..1349774 /gene="splB" /locus_tag="BSU_13930" /old_locus_tag="BSU13930" /label="splB gene" downshifts 1349744 /Source="Nicolas_upshifts" /id="D775" /incds=0 /nref=5 /ntot=113 /MaxReadThrough="0.352" /MaxDrop="3.95383" /score="15.9223136" /energy="-13.2" /TU="NA" /idTUdmin="U1136" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1349789..1350469) /gene="ykwB" /locus_tag="BSU_13940" /old_locus_tag="BSU13940" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase / amidohydrolase" /protein_id="NP_389277.2" /db_xref="EnsemblGenomes-Gn:BSU13940" /db_xref="EnsemblGenomes-Tr:CAB13267" /db_xref="GOA:Q796K9" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12252" /db_xref="UniProtKB/Swiss-Prot:Q796K9" /translation="MIILKQMYVHDGRKFEALTIRNYTETDIERLISLQEECFPPPFP QELLWSEDQLASHIKTFPEGALCALINGRIIGSMTALIVQFEPDSPDHTWAQATDNGS IKNHEPHGNTLYVVDISVSPHYRKLGIGKWLMNTMYELTVDKRLERLLGGGRIPLYYK YAHEISAVQYVEDVMEGRKNDPVLSFLLRCGRSPIRVVSNYLEDKESLNYGVLMEWKN VFYKKASC*" /label="ykwB CDS" gene complement(1349789..1350469) /gene="ykwB" /locus_tag="BSU_13940" /old_locus_tag="BSU13940" /label="ykwB gene" promotor_-10 complement(1350479..1350498) /Source="Nicolas_upshift_promotors" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1350502) /Source="Nicolas_upshifts" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1350513..1350520) /Source="Nicolas_upshift_promotors" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1350554..1350561 /Source="Nicolas_upshift_promotors" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="promotor_-35" promotor_-10 1350575..1350593 /Source="Nicolas_upshift_promotors" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="promotor_-10" upshifts 1350581 /Source="Nicolas_upshifts" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="upshifts" CDS 1350604..1352571 /gene="mcpC" /locus_tag="BSU_13950" /old_locus_tag="BSU13950" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:9721285, 11722727, 12603740, 15317802, 23038252, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9721285, 11722727, 12603740, 15317802, 23038252, 27899502; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_389278.2" /db_xref="EnsemblGenomes-Gn:BSU13950" /db_xref="EnsemblGenomes-Tr:CAB13268" /db_xref="GOA:P54576" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG11533" /db_xref="UniProtKB/Swiss-Prot:P54576" /translation="MFKKLHMKIAVFVSIMLIITVVLLMLSSYLTLKPMITEDGKNTT QNVTQSLEQNIELQLKSYAISLSRLANGELTHTFVTKPSKEASRLFHDDIKQIKDNDD YVAMAYIGTAKKEMFTYPKADFAEDYDPTSRPWYKLAAETPDQVVWTEPYKDVVTGDM IVTASKAILDRQKVIGVASYDLKLSAIQSMVNKQKVPYKGFAFLADASGNLLAHPSNQ GKNISKDQTLQTIASEKKGIQDVNGKMVVYQTIGETGWKVGTQFDTDQLMWISDKMNR ANLWISLIALIITIILSYFLAKTITGPIQQLIVKTKAVSAGDLTVRAESKSKDEVGIL TRDFNLMVENMKEMVEQVRLSSGKVSDTSEQLTAVAAETNETSGQIAKAIEEVAAGAS EQASEVETINEKSESLSTKIRQIAEEAGGIKERSKSSEDASYKGLDALGQLLMKSNEA NMETKKVETMLLDLENQTKNIEEVVTAISNISDQTNLLALNASIEAARAGESGRGFAV VADEVRKLAEQSALSTKHISETVKLIQLETKEASHAMVEASRMNDEQNSAIHETGEVL NTITAEMQSLVQGIDHIYAEIQRMSEEQLAISEAIQSISAISQESAAAAEEVNASTDE QLVTLDKVKHSTETLKHASQELMNTIAKFTL*" /label="mcpC CDS" gene 1350604..1352571 /gene="mcpC" /locus_tag="BSU_13950" /old_locus_tag="BSU13950" /label="mcpC gene" misc_feature complement(1351044..1351059) /Source="Nicolas_upshift_promotors" /id="U1142" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.518481518481518" /psig="0.367632367632368" /xcortree=380 /SigmaFactorBS="cctgtctaagatcgctttcgatgcagtaacaatcatgtctcc tgtcacgacatctttATAAGGTTCCGTCCAAacaacttgatccggggtttcagctgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1351056) /Source="Nicolas_upshifts" /id="U1142" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.518481518481518" /psig="0.367632367632368" /xcortree=380 /SigmaFactorBS="cctgtctaagatcgctttcgatgcagtaacaatcatgtctcc tgtcacgacatctttATAAGGTTCCGTCCAAacaacttgatccggggtttcagctgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1352542 /Source="Nicolas_upshifts" /id="D776" /incds=0 /nref=134 /ntot=209 /MaxReadThrough="3.05506" /MaxDrop="5.75836" /score="24.6367658" /energy="-12.1" /TU="U1141" /idTUdmin="U1141" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 1352615..1352617 /Source="Nicolas_upshift_promotors" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1352633..1352652 /Source="Nicolas_upshift_promotors" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1352643 /Source="Nicolas_upshifts" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1352685) /Source="Nicolas_upshifts" /id="D777" /incds=0 /nref=1 /ntot=91 /MaxReadThrough="2.29647" /MaxDrop="4.49503" /score="37.1302416" /energy="-14.5" /TU="NA" /idTUdmin="U1144" /TUdmin=946 /isTUend="FALSE" /label="downshifts" CDS 1352709..1353575 /gene="ohaC" /locus_tag="BSU_13960" /old_locus_tag="BSU13960" /EC_number="1.1.1.60" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:20941576, 24390483" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20941576, 24390483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-hydroxyacid dehydrogenase (acts on 3-hydroxypropionate with NADP)" /protein_id="NP_389279.1" /db_xref="EnsemblGenomes-Gn:BSU13960" /db_xref="EnsemblGenomes-Tr:CAB13269" /db_xref="GOA:O34948" /db_xref="InterPro:IPR002204" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR015815" /db_xref="InterPro:IPR029154" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13328" /db_xref="UniProtKB/Swiss-Prot:O34948" /translation="MKKTIGFIGLGVMGKSMASHILNDGHPVLVYTRTKEKAESILQK GAIWKDTVKDLSKEADVIITMVGYPSDVEEVYFGSNGIIENAKEGAYLIDMTTSKPSL AKKIAEAAKEKALFALDAPVSGGDIGAQNGTLAIMVGGEKEAFEACMPIFSLMGENIQ YQGPAGSGQHTKMCNQIAIAAGMIGVAEAMAYAQKSGLEPENVLKSITTGAAGSWSLS NLAPRMLQGNFEPGFYVKHFIKDMGIALEEAELMGEEMPGLSLAKSLYDKLAAQGEEN SGTQSIYKLWVK*" /label="ohaC CDS" gene 1352709..1353575 /gene="ohaC" /locus_tag="BSU_13960" /old_locus_tag="BSU13960" /label="ohaC gene" downshifts 1353555 /Source="Nicolas_upshifts" /id="D778" /incds=0 /nref=239 /ntot=266 /MaxReadThrough="2.14032" /MaxDrop="8.18847" /score="41.1703019" /energy="-14.5" /TU="NA" /idTUdmin="U1143" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1353614..1354387) /gene="ykwD" /locus_tag="BSU_13970" /old_locus_tag="BSU13970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389280.2" /db_xref="EnsemblGenomes-Gn:BSU13970" /db_xref="EnsemblGenomes-Tr:CAB13270" /db_xref="InterPro:IPR014044" /db_xref="InterPro:IPR014258" /db_xref="InterPro:IPR035940" /db_xref="SubtiList:BG13329" /db_xref="UniProtKB/Swiss-Prot:O31398" /translation="MKKAFILSAAAAVGLFTFGGVQQASAKELSCQPVVTVKTGNTVQ NMSLNDAVKKLHINTNIKTLNAANEKEMKQLLQKHAKQSNVKVQDVQKTETAKPAQKT TEKAAADQNTASKAPATAEKTNTTTSAPSSVSAYEKKVVELTNAERQKQGLKPLQIDE TLSKSARAKSQDMKDKNYFDHQSPTYGSPFDMMKSFGISYKTAGENIAKGQKTPEEVV KAWMNSEGHRKNILNPNFTHIGVGYVESGSIWTQQFIGK*" /label="ykwD CDS" gene complement(1353614..1354387) /gene="ykwD" /locus_tag="BSU_13970" /old_locus_tag="BSU13970" /label="ykwD gene" downshifts complement(1353631) /Source="Nicolas_upshifts" /id="D779" /incds=0 /nref=31 /ntot=168 /MaxReadThrough="1.32532" /MaxDrop="5.28625" /score="37.1302416" /energy="-14.5" /TU="NA" /idTUdmin="U1144" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1354419..1354438) /Source="Nicolas_upshift_promotors" /id="U1144" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.711288711288711" /psig="0.994005994005994" /xcortree=2987 /SigmaFactorBS="acaatctctatttgtcaaaggaaagtgctggaatctttatga caaaaaagcTATGTTATGATTTTTCTGTAgaaacaaacaactctaggaggttacgaac t" /listShort="ykwD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1354429) /Source="Nicolas_upshifts" /id="U1144" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.711288711288711" /psig="0.994005994005994" /xcortree=2987 /SigmaFactorBS="acaatctctatttgtcaaaggaaagtgctggaatctttatga caaaaaagcTATGTTATGATTTTTCTGTAgaaacaaacaactctaggaggttacgaac t" /listShort="ykwD" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1354662..1354681 /Source="Nicolas_upshift_promotors" /id="U1145" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.825174825174825" /psig="0.998001998001998" /xcortree=3175 /SigmaFactorBS="tattgacagctttttttactccttttcgctgtaacaactatt acaaaGGTGTTACAATTAATCTCAGtatatgtaaatatattgaatgatttgagagggg t" /listShort="S507, pbpH, kinA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1354675 /Source="Nicolas_upshifts" /id="U1145" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.825174825174825" /psig="0.998001998001998" /xcortree=3175 /SigmaFactorBS="tattgacagctttttttactccttttcgctgtaacaactatt acaaaGGTGTTACAATTAATCTCAGtatatgtaaatatattgaatgatttgagagggg t" /listShort="S507, pbpH, kinA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1354677..1354780 /Source="Nicolas_S_feature" /locus_tag="new_1467701_1467804" /HighExp="T4.0H, T3.30H, T3.0H, Etha, T5.0H, T2.30H, LoTm, B60, T2.0H, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S507" CDS 1354724..1356838 /gene="pbpH" /locus_tag="BSU_13980" /old_locus_tag="BSU13980" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12896990, 23199363" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12896990, 23199363; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding enzyme for formation of rod-shaped peptidoglycan cell wall" /protein_id="NP_389281.2" /db_xref="EnsemblGenomes-Gn:BSU13980" /db_xref="EnsemblGenomes-Tr:CAB13271" /db_xref="GOA:Q796K8" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG13286" /db_xref="UniProtKB/Swiss-Prot:Q796K8" /translation="MTEIGREPKKKSKGNRAIRMNLFFLAVFVLFTALIFKLGVVQIV EGEQHEEDAEKSNAKTAYYPAPRGKMYDRNQKVAVDNQSVPEIVYVSTSSTKTEDKIK TAKRLASFIHIDTEFLKERDLRDYWIAAHPKKAAALLKESESNLKGDQAYKLQIERVP DQELKAIQQDDEEMETAAIYTRFSSGNAYEPQIVKAMNPNKSNSNGKNGALLDEKKNS SQRPKNDLTYDEISIVSEHLEELPGIDIVNDWTRKYPYDKTLYSVFGGVTTPDQGLLS DRKDFYLTRGYANNDRVGKSYLEYQYEEYLNSHKEKVEYVEDNKGNVVSQKTIDKGSR GYDLQLSFDMELQAKVEKIIEEEVRNSRARGNYMLDRAFAVMMDPNNGDILSMAGKKI DLKTNKIEDYAIGAFTTQYEMGSAVKGATVLAGYQDGIPHYKYYIDAPMLLGTNLIKK SYTNMGTINELTALQKSSNVYMFNVAMHIAGVTYKPHGSLPADQNDLLKMRNYYSQFG LGVKTGIDLPQESAGMQTTPKTVGGLILDLAIGQYDTYTPLQMAQYISVIANGGYRVQ PRIVTSIHKPGKKDQLGKAIEHRKPKVLNKINNSESDLKQVQTGMKLVTSSGTAKNTF TEDVSGKTGTAETFYYGTNRNWWGKKTYNLTFVGYYPSKKPKVAFSVVVPSVDDDDKI NKIIAKRAIHAYAELEKKHSKK*" /label="pbpH CDS" gene 1354724..1356838 /gene="pbpH" /locus_tag="BSU_13980" /old_locus_tag="BSU13980" /label="pbpH gene" promotor_-10 complement(1356017..1356035) /Source="Nicolas_upshift_promotors" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1356029) /Source="Nicolas_upshifts" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1356051..1356056) /Source="Nicolas_upshift_promotors" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1356819 /Source="Nicolas_upshifts" /id="D780" /incds=0 /nref=139 /ntot=246 /MaxReadThrough="3.36066" /MaxDrop="5.01597" /score="-1.2500858" /energy="-12" /TU="U1145" /idTUdmin="U1145" /TUdmin="-1862" /isTUend="FALSE" /label="downshifts" promotor_-35 1356911..1356919 /Source="Nicolas_upshift_promotors" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1356931..1356949 /Source="Nicolas_upshift_promotors" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1356943 /Source="Nicolas_upshifts" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="upshifts" CDS 1357002..1358822 /gene="kinA" /locus_tag="BSU_13990" /old_locus_tag="BSU13990" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11734624, 14629015, 17350039, 21097618, 22303282, 23169620, 23378509, 23504013, 26712348, 28449380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11734624, 14629015, 17350039, 21097618, 22303282, 23169620, 23378509, 23504013, 26712348, 28449380; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation-specific ATP-dependent protein histidine kinase" /protein_id="NP_389282.1" /db_xref="EnsemblGenomes-Gn:BSU13990" /db_xref="EnsemblGenomes-Tr:CAB13272" /db_xref="GOA:P16497" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013655" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:2VLG" /db_xref="SubtiList:BG10204" /db_xref="UniProtKB/Swiss-Prot:P16497" /translation="MEQDTQHVKPLQTKTDIHAVLASNGRIIYISANSKLHLGYLQGE MIGSFLKTFLHEEDQFLVESYFYNEHHLMPCTFRFIKKDHTIVWVEAAVEIVTTRAER TEREIILKMKVLEEETGHQSLNCEKHEIEPASPESTTYITDDYERLVENLPSPLCISV KGKIVYVNSAMLSMLGAKSKDAIIGKSSYEFIEEEYHDIVKNRIIRMQKGMEVGMIEQ TWKRLDGTPVHLEVKASPTVYKNQQAELLLLIDISSRKKFQTILQKSRERYQLLIQNS IDTIAVIHNGKWVFMNESGISLFEAATYEDLIGKNIYDQLHPCDHEDVKERIQNIAEQ KTESEIVKQSWFTFQNRVIYTEMVCIPTTFFGEAAVQVILRDISERKQTEELMLKSEK LSIAGQLAAGIAHEIRNPLTAIKGFLQLMKPTMEGNEHYFDIVFSELSRIELILSELL MLAKPQQNAVKEYLNLKKLIGEVSALLETQANLNGIFIRTSYEKDSIYINGDQNQLKQ VFINLIKNAVESMPDGGTVDIIITEDEHSVHVTVKDEGEGIPEKVLNRIGEPFLTTKE KGTGLGLMVTFNIIENHQGVIHVDSHPEKGTAFKISFPKK*" /label="kinA CDS" gene 1357002..1358822 /gene="kinA" /locus_tag="BSU_13990" /old_locus_tag="BSU13990" /label="kinA gene" CDS complement(1358833..1360014) /gene="dapX" /locus_tag="BSU_14000" /old_locus_tag="BSU14000" /EC_number="2.6.1.83" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 14523133, 14627808, 19948795" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 14523133, 14627808, 19948795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-L,L-diaminopimelate aminotransferase" /protein_id="NP_389283.2" /db_xref="EnsemblGenomes-Gn:BSU14000" /db_xref="EnsemblGenomes-Tr:CAB13273" /db_xref="GOA:P16524" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10205" /db_xref="UniProtKB/Swiss-Prot:P16524" /translation="MEHLLNPKAREIEISGIRKFSNLVAQHEDVISLTIGQPDFFTPH HVKAAAKKAIDENVTSYTPNAGYLELRQAVQLYMKKKADFNYDAESEIIITTGASQAI DAAFRTILSPGDEVIMPGPIYPGYEPIINLCGAKPVIVDTTSHGFKLTARLIEDALTP NTKCVVLPYPSNPTGVTLSEEELKSIAALLKGRNVFVLSDEIYSELTYDRPHYSIATY LRDQTIVINGLSKSHSMTGWRIGFLFAPKDIAKHILKVHQYNVSCASSISQKAALEAV TNGFDDALIMREQYKKRLDYVYDRLVSMGLDVVKPSGAFYIFPSIKSFGMTSFDFSMA LLEDAGVALVPGSSFSTYGEGYVRLSFACSMDTLREGLDRLELFVLKKREAMQTINNG V*" /label="dapX CDS" gene complement(1358833..1360014) /gene="dapX" /locus_tag="BSU_14000" /old_locus_tag="BSU14000" /label="dapX gene" downshifts complement(1358867) /Source="Nicolas_upshifts" /id="D781" /incds=0 /nref=255 /ntot=267 /MaxReadThrough="1.89632" /MaxDrop="6.70715" /score="-6.17975559" /energy="-4.7" /TU="NA" /idTUdmin="U1148" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1360042..1360061) /Source="Nicolas_upshift_promotors" /id="U1148" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=1466 /SigmaFactorBS="gaaaaaaggcgcatacaatcgaaatatatcagttaaaaaggt gacaaatgatcagctAGTGGTAAAATAGGATAAACtcattatatttgttaaggtgatg a" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1360058) /Source="Nicolas_upshifts" /id="U1148" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=1466 /SigmaFactorBS="gaaaaaaggcgcatacaatcgaaatatatcagttaaaaaggt gacaaatgatcagctAGTGGTAAAATAGGATAAACtcattatatttgttaaggtgatg a" /listShort="patA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1360090..1360108) /Source="Nicolas_upshift_promotors" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1360102) /Source="Nicolas_upshifts" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1360104..1360172) /Source="Nicolas_S_feature" /locus_tag="new_1473128_1473196_c" /HighExp="M9-stat, Lbtran, Lbstat, T3.30H, T3.0H, T2.30H, M0t90, T4.0H, M40t90, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S508" promotor_-35 complement(1360123..1360128) /Source="Nicolas_upshift_promotors" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1360166..1360185) /Source="Nicolas_upshift_promotors" /id="U1150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=3165 /SigmaFactorBS="ttgattatggctattaatgaaattggcacatataaacaataa tagaaCATGATACAATAAAGACAATcaaatcgctggttgtcttctttttttctgaaaa g" /listShort="S508, patA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1360172) /Source="Nicolas_upshifts" /id="U1150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=3165 /SigmaFactorBS="ttgattatggctattaatgaaattggcacatataaacaataa tagaaCATGATACAATAAAGACAATcaaatcgctggttgtcttctttttttctgaaaa g" /listShort="S508, patA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1360216..1360377) /gene="ykzT" /locus_tag="BSU_14009" /old_locus_tag="BSU14009" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097722.1" /db_xref="EnsemblGenomes-Gn:BSU14009" /db_xref="EnsemblGenomes-Tr:CAX52613" /db_xref="UniProtKB/Swiss-Prot:C0H406" /translation="MGTLVIFKENEMTVLEDISEETYLNMKKESADLQEEHPPYLIWH EDLHFDYGY*" /label="ykzT CDS" gene complement(1360216..1360377) /gene="ykzT" /locus_tag="BSU_14009" /old_locus_tag="BSU14009" /label="ykzT gene" promotor_-10 complement(1360400..1360419) /Source="Nicolas_upshift_promotors" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1360413) /Source="Nicolas_upshifts" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1360433..1360440) /Source="Nicolas_upshift_promotors" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1360514..1360521 /Source="Nicolas_upshift_promotors" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1360533 /Source="Nicolas_upshifts" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1360534..1360552 /Source="Nicolas_upshift_promotors" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1360581..1361492 /gene="cheV" /locus_tag="BSU_14010" /old_locus_tag="BSU14010" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11553614, 12864845, 14731274, 14993307, 26844549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11553614, 12864845, 14731274, 14993307, 26844549; Product type r: regulator" /codon_start=1 /transl_table=11 /product="coupling protein and response regulator for CheAactivity in response to attractants (chemotaxis)" /protein_id="NP_389284.1" /db_xref="EnsemblGenomes-Gn:BSU14010" /db_xref="EnsemblGenomes-Tr:CAB13274" /db_xref="GOA:P37599" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR002545" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024181" /db_xref="InterPro:IPR036061" /db_xref="SubtiList:BG10823" /db_xref="UniProtKB/Swiss-Prot:P37599" /translation="MSLQQYEILLDSGTNELEIVKFGVGENAFGINVMKVREIIQPVE VTSVPHSHQHVEGMIKLRGEILPVISLFSFFGVEPEGSKDEKYIVTEFNKRKIVFHVG SVSQIHRVSWEAIEKPTSLNQGMERHLTGIIKLEDLMIFLPDYEKIIYDIESDSGVDT YNMHTEGFDERRTDKKLIIVEDSPLLMRLLQDELKEAGYNNIASFENGKEAYEYIMNL AENETDLSKQIDMIITDIEMPKMDGHRLTKLLKENPKSSDVPVMIFSSLITDDLRHRG EVVGADEQISKPEISDLIKKVDTYVIE*" /label="cheV CDS" gene 1360581..1361492 /gene="cheV" /locus_tag="BSU_14010" /old_locus_tag="BSU14010" /label="cheV gene" downshifts complement(1360586) /Source="Nicolas_upshifts" /id="D782" /incds=0 /nref=1 /ntot=50 /MaxReadThrough="1.14523" /MaxDrop="3.62759" /score="-8.29055697" /energy="-7.7" /TU="NA" /idTUdmin="U1154" /TUdmin=968 /isTUend="FALSE" /label="downshifts" promotor_-35 1361035..1361043 /Source="Nicolas_upshift_promotors" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1361057..1361074 /Source="Nicolas_upshift_promotors" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1361060 /Source="Nicolas_upshifts" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1361477 /Source="Nicolas_upshifts" /id="D783" /incds=0 /nref=188 /ntot=251 /MaxReadThrough="4.61331" /MaxDrop="6.23797" /score="15.4598573" /energy="-13.1" /TU="U1152" /idTUdmin="U1153" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1361536..1362000) /gene="kre" /locus_tag="BSU_14020" /old_locus_tag="BSU14020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of transcription factor ComK function via modulation of mRNA stability" /protein_id="NP_389285.1" /db_xref="EnsemblGenomes-Gn:BSU14020" /db_xref="EnsemblGenomes-Tr:CAB13275" /db_xref="InterPro:IPR025552" /db_xref="SubtiList:BG11202" /db_xref="UniProtKB/Swiss-Prot:P42430" /translation="MDDHAYTKDLQPTVENLSKAVYTVNRHAKTAPNPKYLYLLKKRA LQKLVKEGKGKKIGLHFSKNPRFSQQQSDVLISIGDYYFHMPPTKEDFEHLPHLGTLN QSYRNPKAQMSLTKAKHLLQEYVGMKEKPLVPNRQQPAYHKPVFKKLGESYF*" /label="kre CDS" gene complement(1361536..1362000) /gene="kre" /locus_tag="BSU_14020" /old_locus_tag="BSU14020" /label="kre gene" downshifts complement(1361554) /Source="Nicolas_upshifts" /id="D784" /incds=0 /nref=212 /ntot=260 /MaxReadThrough="2.67186" /MaxDrop="6.66359" /score="16.1985615" /energy="-13.1" /TU="NA" /idTUdmin="U1154" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1362030..1362049) /Source="Nicolas_upshift_promotors" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1362040) /Source="Nicolas_upshifts" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1362064..1362071) /Source="Nicolas_upshift_promotors" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1362126..1363418) /gene="ykuC" /locus_tag="BSU_14030" /old_locus_tag="BSU14030" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_389286.2" /db_xref="EnsemblGenomes-Gn:BSU14030" /db_xref="EnsemblGenomes-Tr:CAB13276" /db_xref="GOA:O31695" /db_xref="InterPro:IPR004751" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13287" /db_xref="UniProtKB/Swiss-Prot:O31695" /translation="MDIFKNRNFVRLFFAALASQMGTTVGNMAFAFFLLDRFSSQPSY TTLAELMYSLPTIFVFLIVGVVADRFDRKKVAENCDWIRAGLTVVLFFTLFTGNIPLV FCILFIRSAVTKFFFPAENSLVQAILPKEHYAKAAGLNQMLFSIFMVFGVGIGAFMYN TIGIEGAIILDFVSFIISGLLIRSCRIPKEARQPNGAFSWRKTSVKDSINDFREGILY ILKNKLLASLIFGFFIFGFVNGGFAVLPMFTMKYGLAPDRYEWHTSVFTIALGFGLLA GSVIGTLISKKVKPHFLMSIPIFIAGLLIFVLGYTNILWVYYAAAFALGMCIGPINIA IGGWMPKIVHPKLMGRVSGMQDPFMMFAQSLTLGLVALLFPKFVSNIDYLYYGMGVII LLVFIFYFIALPKYSAQAVEVNVQEAFQEQPKKKARSV*" /label="ykuC CDS" gene complement(1362126..1363418) /gene="ykuC" /locus_tag="BSU_14030" /old_locus_tag="BSU14030" /label="ykuC gene" downshifts complement(1362148) /Source="Nicolas_upshifts" /id="D785" /incds=0 /nref=37 /ntot=206 /MaxReadThrough="4.24449" /MaxDrop="4.31411" /score="3.5676583" /energy="-14.2" /TU="U1155" /idTUdmin="U1156" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1363442..1363461) /Source="Nicolas_upshift_promotors" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="promotor_-10" upshifts complement(1363446) /Source="Nicolas_upshifts" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="upshifts" promotor_-35 complement(1363477..1363481) /Source="Nicolas_upshift_promotors" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="promotor_-35" CDS complement(1363494..1363988) /gene="ltdD" /locus_tag="BSU_14040" /old_locus_tag="BSU14040" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11011148, 16287140, 23832002" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11011148, 16287140, 23832002; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="murein L,D-transpeptidase" /protein_id="NP_389287.1" /db_xref="EnsemblGenomes-Gn:BSU14040" /db_xref="EnsemblGenomes-Tr:CAB13277" /db_xref="GOA:O34816" /db_xref="InterPro:IPR005490" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="PDB:1Y7M" /db_xref="PDB:2MTZ" /db_xref="PDB:3ZQD" /db_xref="PDB:4A1I" /db_xref="PDB:4A1J" /db_xref="PDB:4A1K" /db_xref="PDB:4A52" /db_xref="SubtiList:BG13288" /db_xref="UniProtKB/Swiss-Prot:O34816" /translation="MLTYQVKQGDTLNSIAADFRISTAALLQANPSLQAGLTAGQSIV IPGLPDPYTIPYHIAVSIGAKTLTLSLNNRVMKTYPIAVGKILTQTPTGEFYIINRQR NPGGPFGAYWLSLSKQHYGIHGTNNPASIGKAVSKGCIRMHNKDVIELASIVPNGTRV TINR*" /label="ltdD CDS" gene complement(1363494..1363988) /gene="ltdD" /locus_tag="BSU_14040" /old_locus_tag="BSU14040" /label="ltdD gene" promotor_-10 complement(1364004..1364023) /Source="Nicolas_upshift_promotors" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1364020) /Source="Nicolas_upshifts" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1364037..1364046) /Source="Nicolas_upshift_promotors" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1364045..1364905) /gene="ppeE" /locus_tag="BSU_14050" /old_locus_tag="BSU14050" /EC_number="3.1.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22767609, 24140208" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22767609, 24140208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported metallophosphoesterase (Mn2+ and Zn2+)" /protein_id="NP_389288.2" /db_xref="EnsemblGenomes-Gn:BSU14050" /db_xref="EnsemblGenomes-Tr:CAB13278" /db_xref="GOA:O34870" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR019546" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13289" /db_xref="UniProtKB/Swiss-Prot:O34870" /translation="MKKMSRRQFLKGMFGALAAGALTAGGGYGYARYLEPHMIETTEH TIKSSLIPHGFDGFKIVQFSDAHLSDYFTLEDLKTVILTINESKPDLIVFTGDIIDNP DTYQHHQAVIPLLRKLNAPFGKLCIYGNHDHGGYGTAVYKSLMTAGGFTVYRNGYQTL SLADGSKIEIASLDDLMLGNPDYEGTLSRLSDRLFSILLVHEPDAALKTTDYPVNLQL SGHTHGGQIQLPFYGPIITPPYGKVYTEGMYQTGSTHIYVNRGLGMTRLPLRFLAKPE ITVFTLKSTN*" /label="ppeE CDS" gene complement(1364045..1364905) /gene="ppeE" /locus_tag="BSU_14050" /old_locus_tag="BSU14050" /label="ppeE gene" misc_feature complement(1364926..1364945) /Source="Nicolas_upshift_promotors" /id="U1157" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.885114885114885" /psig="0.997002997002997" /xcortree=1947 /SigmaFactorBS="attatatccctgcctctgtcagcacatgctcatatgagattt ttatcagatacaGATGATATAATAGAAAAACTctattaaaggttggtttgaaatgaaa a" /listShort="ykuE, ykuD" /listLong="ykuC, ykyB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1364939) /Source="Nicolas_upshifts" /id="U1157" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.885114885114885" /psig="0.997002997002997" /xcortree=1947 /SigmaFactorBS="attatatccctgcctctgtcagcacatgctcatatgagattt ttatcagatacaGATGATATAATAGAAAAACTctattaaaggttggtttgaaatgaaa a" /listShort="ykuE, ykuD" /listLong="ykuC, ykyB" /label="upshifts" promotor_-35 1364976..1364983 /Source="Nicolas_upshift_promotors" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="promotor_-35" promotor_-10 1364999..1365018 /Source="Nicolas_upshift_promotors" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="promotor_-10" upshifts 1365012 /Source="Nicolas_upshifts" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="upshifts" CDS 1365048..1365812 /gene="fadH" /locus_tag="BSU_14060" /old_locus_tag="BSU14060" /EC_number="1.3.1.34" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2,4-dienoyl-CoA reductase" /protein_id="NP_389289.1" /db_xref="EnsemblGenomes-Gn:BSU14060" /db_xref="EnsemblGenomes-Tr:CAB13279" /db_xref="GOA:O34717" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13290" /db_xref="UniProtKB/Swiss-Prot:O34717" /translation="MEKKAVIITGGSSGMGKAMAKKQAELGWHVMVTGRNHEALEETK KEIQTFEGQVACFQMDVRSDSAASDMIKEAVKAFGRLDALINNAAGNFICPAEKLTPN GWKAVIEIVLNGTFFCSQAAARHWIDQKQQGVILNMAATYAWGAGAGVVHSAAAKAGV LSLTRTLAVEWGSKYGIRTNAIAPGPIERTGGAEKLFESEKAMARTMNSVPLGRLGTP EEIAALAAFLLSDEASYINGDCITMDGGQWLNPYPF*" /label="fadH CDS" gene 1365048..1365812 /gene="fadH" /locus_tag="BSU_14060" /old_locus_tag="BSU14060" /label="fadH gene" S_feature 1365813..1365961 /Source="Nicolas_S_feature" /locus_tag="new_1478837_1478985" /HighExp="T0.30H, T1.0H, B60, Sw, BC, LoTm, M9-stat, S8, S7, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S509" misc_feature 1365942..1365960 /Source="Nicolas_upshift_promotors" /id="U1159" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=1521 /SigmaFactorBS="tgataacacatagagctttatttgtttatgaggtgttgtGTC ATACGTAAGCCACCTAatatatgaaaggtatattttaaaaggggagacgaaatatgaa g" /listShort="S510, fadG, ykzU, ykuH, S511, ykuI, S512" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1365963..1366112 /Source="Nicolas_S_feature" /locus_tag="new_1478987_1479136" /HighExp="T0.30H, M40t90, T1.0H, B60, BC, Sw, LPh, LoTm, M9-stat, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0, 0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S510" upshifts 1365963 /Source="Nicolas_upshifts" /id="U1159" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=1521 /SigmaFactorBS="tgataacacatagagctttatttgtttatgaggtgttgtGTC ATACGTAAGCCACCTAatatatgaaaggtatattttaaaaggggagacgaaatatgaa g" /listShort="S510, fadG, ykzU, ykuH, S511, ykuI, S512" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1366010) /Source="Nicolas_upshifts" /id="D786" /incds=0 /nref=3 /ntot=49 /MaxReadThrough="1.82681" /MaxDrop="3.39884" /score="-0.170855674" /energy="-4.8" /TU="NA" /idTUdmin="U1157" /TUdmin="-2542" /isTUend="FALSE" /label="downshifts" CDS 1366113..1367843 /gene="ykuG" /locus_tag="BSU_14071" /old_locus_tag="BSU14071" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative cell wall-binding protein" /protein_id="YP_003097723.1" /db_xref="EnsemblGenomes-Gn:BSU14071" /db_xref="EnsemblGenomes-Tr:CAX52614" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR015020" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="UniProtKB/Swiss-Prot:O34320" /translation="MDEMVLLTQEWLNETYKGKSGYNSIEENGKTGWKTMYALTRALQ LELGITQTSDSFGPTTLRKLKELGPISTSTNSKKNIVKIIQGALYCKGYGPGGLTGTF GQGTKEAIAEMQLHMGLSKTDGVVTPKVFKALLNMDSYILLNGASEKVRSIQQWLNNK YYNRENFYFMPCDGLYSRDTQKSLVYAIQYEEGLSDSIANGNFGPTTQRLIPVLRIGE TDEKNSFIHLFQAALIFNGYNVPFDGVYSESVRSKVKAFQSFAKLQQSGTADFQTWAS LLVSTGDPNRKGVACDSITQITSDRAESLKRAGYKIVGRYLTNAPGSTLNKKIQPGEL ETILKSGLNVFPIYQTYGGATNYFNKEQGKKDAFAAYKAAKEYGFKNNTVIYFAVDYD AYGNDLNNNIIPHFEGINEIMNGFLGSTYKIGIYAPRNVCTIVSKKGLAFASFVSGMS TGFSGNLGYPLPYNWAFDQISTITVGNGSGMIEIDNDICSGLDNGVNTINIVPSENKK FFDQIDVLYETAEKYAQMQSDLNNGVKKTQLANELVAQYLRKDDYKGWKWVPTAGQID PIYREWAVKR*" /label="ykuG CDS" gene 1366113..1367843 /gene="ykuG" /locus_tag="BSU_14071" /old_locus_tag="BSU14071" /label="ykuG gene" CDS 1367909..1368427 /gene="ykzU" /locus_tag="BSU_14072" /old_locus_tag="BSU14072" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097724.1" /db_xref="EnsemblGenomes-Gn:BSU14072" /db_xref="EnsemblGenomes-Tr:CAX52615" /db_xref="UniProtKB/Swiss-Prot:C0H408" /translation="MATYNAIIYSGGYSQTLRDFAGWTGDLLTTIQDMKLHAQEFNSP YDAAMKIIGNMYQFSLDDLFSDVDAINLANKTSVGANAQPLNIAIRDYYSNNDCMNRF TQFVNNRFDGSLDKIFSEAEYYLNTNLDPVVVPIRLAFKRAFDVEDYSEEIGKITAQA FRDVIEKKMISE*" /label="ykzU CDS" gene 1367909..1368427 /gene="ykzU" /locus_tag="BSU_14072" /old_locus_tag="BSU14072" /label="ykzU gene" downshifts 1368425 /Source="Nicolas_upshifts" /id="D787" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="5.57306" /MaxDrop="3.8585" /score="8.20824413" /energy="-13" /TU="U1158,U1159" /idTUdmin="U1158" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" promotor_-35 1368470..1368475 /Source="Nicolas_upshift_promotors" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1368488..1368507 /Source="Nicolas_upshift_promotors" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1368491 /Source="Nicolas_upshifts" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="upshifts" CDS 1368523..1369071 /gene="ykuH" /locus_tag="BSU_14080" /old_locus_tag="BSU14080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389291.1" /db_xref="EnsemblGenomes-Gn:BSU14080" /db_xref="EnsemblGenomes-Tr:CAB13281" /db_xref="GOA:O31696" /db_xref="SubtiList:BG13292" /db_xref="UniProtKB/Swiss-Prot:O31696" /translation="MKKLLKKLVVLFLSSLVIIFNVWYFIICAFSPEYYQNTNLTSNE IIRFEKLYHIDFPDETKFIKAREYLAGPGGDTSAVLYVSLPTKRVEKVLSDYTYMKIN YTDNVGSMYGVDVSKSVAGLTTLTFGTYDKKGTFYNMKHDDDWMYKGTDWNLYFWTAA SYNAVIFVFVLVIVKQMNKILN*" /label="ykuH CDS" gene 1368523..1369071 /gene="ykuH" /locus_tag="BSU_14080" /old_locus_tag="BSU14080" /label="ykuH gene" S_feature 1369072..1369223 /Source="Nicolas_S_feature" /locus_tag="new_1482096_1482247" /HighExp="HiOs, LPhT, Salt, T0.0H, HiTm, T-0.40H, Fru, T-1.10H, LPh, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0" /TUlongSig="SigA" /TUlongPSig="0.97" /label="S511" CDS 1369224..1370447 /gene="ykuI" /locus_tag="BSU_14090" /old_locus_tag="BSU14090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19244251, 28536559; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative cyclic-di-GMP receptor (no phosphodiesterase activity)" /protein_id="NP_389292.1" /db_xref="EnsemblGenomes-Gn:BSU14090" /db_xref="EnsemblGenomes-Tr:CAB13282" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR018842" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR035919" /db_xref="PDB:2BAS" /db_xref="PDB:2W27" /db_xref="SubtiList:BG13293" /db_xref="UniProtKB/Swiss-Prot:O35014" /translation="MLDPLDILTNIDDVLPYYQAIFSAEEQKVVGYEVLGRILADSEI QSLGPFFLDAGIPEEYKLEVDNRIIRQALDRFLEADSDLLIFMNQDANLLMLDHGESF LELLKEYEAKGIELHRFVLEITEHNFEGDIEQLYHMLAYYRTYGIKIAVDNIGKESSN LDRIALLSPDLLKIDLQALKVSQPSPSYEHVLYSISLLARKIGAALLYEDIEANFQLQ YAWRNGGRYFQGYYLVSPSETFLERDVLKQRLKTEFHQFITHEKKKLETVYEHSEQFY KRVHQAVTSLRKNNLSSDDDFIKKLAEELTDCSFRIYMCDEEGDQLTGNVFKQDGEWI YQPEYAEKNWSWRPYFLENIMRMRNLRKGFFSDLYSDLETGEMIRTFSYPMDDQMYLF IDLPYSYLYEQDGLI*" /label="ykuI CDS" gene 1369224..1370447 /gene="ykuI" /locus_tag="BSU_14090" /old_locus_tag="BSU14090" /label="ykuI gene" promotor_-10 complement(1370410..1370428) /Source="Nicolas_upshift_promotors" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1370420) /Source="Nicolas_upshifts" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1370426 /Source="Nicolas_upshifts" /id="D788" /incds=0 /nref=132 /ntot=229 /MaxReadThrough="3.48305" /MaxDrop="4.61382" /score="32.6727777" /energy="-7.5" /TU="U1159" /idTUdmin="U1160" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 complement(1370443..1370448) /Source="Nicolas_upshift_promotors" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1370496..1370503 /Source="Nicolas_upshift_promotors" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-35" S_feature 1370515..1370616 /Source="Nicolas_S_feature" /locus_tag="new_1483539_1483640" /HighExp="B36, B60, nit, Pyr, BI, HiOs, T-0.40H, S5, GM 15, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0" /TUlongSig="NA" /TUlongPSig="NA" /label="S512" upshifts 1370515 /Source="Nicolas_upshifts" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="upshifts" promotor_-10 1370518..1370537 /Source="Nicolas_upshift_promotors" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-10" misc_RNA 1370533..1370616 /gene="fsrA" /locus_tag="BSU_misc_RNA_69" /product="regulatory RNA controlling iron-dependent metabolism" /experiment="publication(s) with functional evidences, PMID:18697947, 22389480, 22427629, 24576839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947, 22389480, 22427629, 24576839; Product type n: RNA" /function="12: Regulatory functions" /label="fsrA RNA" gene 1370533..1370616 /gene="fsrA" /locus_tag="BSU_misc_RNA_69" /label="fsrA gene" downshifts 1370573 /Source="Nicolas_upshifts" /id="D789" /incds=0 /nref=61 /ntot=192 /MaxReadThrough="6.41968" /MaxDrop="7.54463" /score="16.5898261" /energy="-8.8" /TU="U1159,U1162" /idTUdmin="U1159" /TUdmin="-74" /isTUend="FALSE" /label="downshifts" promotor_-35 1370627..1370632 /Source="Nicolas_upshift_promotors" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="promotor_-35" S_feature 1370647..1370931 /Source="Nicolas_S_feature" /locus_tag="new_1483671_1483955" /HighExp="S4, H2O2, S5, Paraq, B60, nit, GM 10, B36, GM 25, GM 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.147452" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S513" upshifts 1370647 /Source="Nicolas_upshifts" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="upshifts" promotor_-10 1370649..1370667 /Source="Nicolas_upshift_promotors" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="promotor_-10" promotor_-35 1370908..1370914 /Source="Nicolas_upshift_promotors" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-35" promotor_-10 1370928..1370939 /Source="Nicolas_upshift_promotors" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-10" S_feature 1370933..1371020 /Source="Nicolas_S_feature" /locus_tag="new_1483957_1484044" /HighExp="S5, S4, H2O2, B60, Paraq, nit, B36, GM 10, S7, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigEF, SigA" /TUshortPSig="0.999, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S514" upshifts 1370933 /Source="Nicolas_upshifts" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="upshifts" misc_feature 1371009..1371028 /Source="Nicolas_upshift_promotors" /id="U1165" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.48951048951049" /psig=1 /xcortree=2552 /SigmaFactorBS="ttttctttgcttaaattcagcagtgaaaatgccatcctgtcc gacttTATGGTATGATGCTCAATAGaacttgtattataataaatacttgttgatttga a" /listShort="ykuJ, S515, ykuK, ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1371022 /Source="Nicolas_upshifts" /id="U1165" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.48951048951049" /psig=1 /xcortree=2552 /SigmaFactorBS="ttttctttgcttaaattcagcagtgaaaatgccatcctgtcc gacttTATGGTATGATGCTCAATAGaacttgtattataataaatacttgttgatttga a" /listShort="ykuJ, S515, ykuK, ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="upshifts" CDS 1371093..1371332 /gene="ykuJ" /locus_tag="BSU_14100" /old_locus_tag="BSU14100" /function="10.3: tRNA and rRNA base modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16387657, 18436958; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-specific modification enzyme subunit" /protein_id="NP_389293.1" /db_xref="EnsemblGenomes-Gn:BSU14100" /db_xref="EnsemblGenomes-Tr:CAB13283" /db_xref="InterPro:IPR014904" /db_xref="PDB:2FFG" /db_xref="SubtiList:BG13294" /db_xref="UniProtKB/Swiss-Prot:O34588" /translation="MSQLMGIITRLQSLQETAEAANEPMQRYFEVNGEKICSVKYFEK NQTFELTVFQKGEKPNTYPFDNIDMVSIEIFELLQ*" /label="ykuJ CDS" gene 1371093..1371332 /gene="ykuJ" /locus_tag="BSU_14100" /old_locus_tag="BSU14100" /label="ykuJ gene" S_feature 1371333..1371441 /Source="Nicolas_S_feature" /locus_tag="new_1484357_1484465" /HighExp="H2O2, LoTm, G135, Paraq, G180, LBGexp, G150, Oxctl, dia0, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S515" CDS 1371442..1371960 /gene="ykuK" /locus_tag="BSU_14110" /old_locus_tag="BSU14110" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16165328, 24464998; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-binding enzyme component" /protein_id="NP_389294.1" /db_xref="EnsemblGenomes-Gn:BSU14110" /db_xref="EnsemblGenomes-Tr:CAB13284" /db_xref="InterPro:IPR007405" /db_xref="SubtiList:BG13295" /db_xref="UniProtKB/Swiss-Prot:O34776" /translation="MADSFLFYNLSEAQMTFQDVMERLKAFVQKDPRSSYVLSIGTDS QVYRDYTKFITALHLHRTGKGAWGCLKNHTVDRPIHSLREKISLETAYSQETAAHILD GHLMDITDLLLPFTGEGADLTFEVHLDIGKKGLTKDLIQEMTGRITSMGIEAKIKPDS YTAFSYANRFTK*" /label="ykuK CDS" gene 1371442..1371960 /gene="ykuK" /locus_tag="BSU_14110" /old_locus_tag="BSU14110" /label="ykuK gene" promotor_-35 1371997..1372004 /Source="Nicolas_upshift_promotors" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1372018..1372037 /Source="Nicolas_upshift_promotors" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1372032 /Source="Nicolas_upshifts" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="upshifts" CDS 1372094..1372291 /gene="abbA" /locus_tag="BSU_14120" /old_locus_tag="BSU14120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18840696, 24534728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18840696, 24534728; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of AbrB repressor" /protein_id="NP_389295.1" /db_xref="EnsemblGenomes-Gn:BSU14120" /db_xref="EnsemblGenomes-Tr:CAB13285" /db_xref="GOA:O31697" /db_xref="InterPro:IPR025446" /db_xref="PDB:2LZF" /db_xref="SubtiList:BG13334" /db_xref="UniProtKB/Swiss-Prot:O31697" /translation="MRMSLIGERFTEEEQKLLLNILINHEYAIELLSSEINDIETGTK NVDGTTYKKLVTLYDRFRFEN*" /label="abbA CDS" gene 1372094..1372291 /gene="abbA" /locus_tag="BSU_14120" /old_locus_tag="BSU14120" /label="abbA gene" downshifts 1372287 /Source="Nicolas_upshifts" /id="D790" /incds=0 /nref=114 /ntot=265 /MaxReadThrough="5.72556" /MaxDrop="4.65809" /score="2.45376472" /energy="-6.8" /TU="U1165,U1166" /idTUdmin="U1162" /TUdmin=12 /isTUend="TRUE" /label="downshifts" S_feature 1372332..1372428 /Source="Nicolas_S_feature" /locus_tag="new_1485356_1485452" /HighExp="M9-stat, T3.30H, T3.0H, T4.0H, M0t90, T1.0H, T5.0H, T2.30H, T1.30H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.23094000000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF, SigEF, SigA" /TUlongPSig="0.999, 0.997, 1" /label="S516" CDS 1372429..1372872 /gene="ykuL" /locus_tag="BSU_14130" /old_locus_tag="BSU14130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11985717; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA-binding protein" /protein_id="NP_389296.1" /db_xref="EnsemblGenomes-Gn:BSU14130" /db_xref="EnsemblGenomes-Tr:CAB13286" /db_xref="PDB:1YAV" /db_xref="SubtiList:BG13296" /db_xref="UniProtKB/Swiss-Prot:O31698" /translation="MISLQSDQLLEATVGQFMIEADKVAHVQVGNNLEHALLVLTKTG YTAIPVLDPSYRLHGLIGTNMIMNSIFGLERIEFEKLDQITVEEVMLTDIPRLHINDP IMKGFGMVINNGFVCVENDEQVFEGIFTRRVVLKELNKHIRSLNK*" /label="ykuL CDS" gene 1372429..1372872 /gene="ykuL" /locus_tag="BSU_14130" /old_locus_tag="BSU14130" /label="ykuL gene" S_feature 1372873..1372980 /Source="Nicolas_S_feature" /locus_tag="new_1485897_1486004" /HighExp="M0t90, M40t90, M9-stat, T1.0H, T3.30H, T3.0H, T4.0H, S2, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF, SigEF, SigA" /TUlongPSig="0.999, 0.997, 1" /label="S517" promotor_-35 1372948..1372953 /Source="Nicolas_upshift_promotors" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1372968..1372987 /Source="Nicolas_upshift_promotors" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1372982 /Source="Nicolas_upshifts" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="upshifts" CDS 1373021..1373902 /gene="ccpC" /locus_tag="BSU_14140" /old_locus_tag="BSU14140" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14636591, 16352834, 16395550, 23139400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14636591, 16352834, 16395550, 23139400; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of citB and citZ" /protein_id="NP_389297.1" /db_xref="EnsemblGenomes-Gn:BSU14140" /db_xref="EnsemblGenomes-Tr:CAB13287" /db_xref="GOA:O34827" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13297" /db_xref="UniProtKB/Swiss-Prot:O34827" /translation="MQLQELHMLVVLAEELNMRKAAERLFVSQPALSQRLQTIEKAWG TKIFLRSQKGLTVTPAGEKIIQFANDVTLEQERIRENIDELEGEIHGTLKLAVASIIG QHWLPKVLKTYVEKYPNAKISLITGWSSEMLKSLYEDQVHIGIIRGNPEWKGRKDYLM TDHLYLVDTEISCIEDIAHTERPFIQFKSDSTYFQEIQHWWHQKFKTSPKQTILVDQI ETCKQMALHGIGYAILPSVTLQNEDKVNKMPLLDMKGHPIGRDTWLLGYEPAFELKQV QAFVQVIKDMLDQENPF*" /label="ccpC CDS" gene 1373021..1373902 /gene="ccpC" /locus_tag="BSU_14140" /old_locus_tag="BSU14140" /label="ccpC gene" downshifts 1373881 /Source="Nicolas_upshifts" /id="D791" /incds=0 /nref=168 /ntot=242 /MaxReadThrough="1.76921" /MaxDrop="5.2505" /score="37.6563581" /energy="-8.3" /TU="NA" /idTUdmin="U1165" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1373937..1373944 /Source="Nicolas_upshift_promotors" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-35" promotor_-10 1373959..1373978 /Source="Nicolas_upshift_promotors" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-10" upshifts 1373964 /Source="Nicolas_upshifts" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="upshifts" CDS 1374014..1374490 /gene="fldN" /locus_tag="BSU_14150" /old_locus_tag="BSU14150" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12354229, 15449930, 17127770, 20186410, 21665975, 24214949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15449930, 17127770, 20186410, 21665975, 24214949; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="short-chain flavodoxin (acts in lipid desaturation)" /protein_id="NP_389298.1" /db_xref="EnsemblGenomes-Gn:BSU14150" /db_xref="EnsemblGenomes-Tr:CAB13288" /db_xref="GOA:O34737" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010087" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13298" /db_xref="UniProtKB/Swiss-Prot:O34737" /translation="MAKALITYASMSGNTEDIAFIIKDTLQEYELDIDCVEINDMDAS CLTSYDYVLIGTYTWGDGDLPYEAEDFFEEVKQIQLNGLKTACFGSGDYSYPKFCEAV NLFNVMLQEAGAAVYQETLKIELAPETDEDVESCRAFARGFLAWADYMNKEKIHVS*" /label="fldN CDS" gene 1374014..1374490 /gene="fldN" /locus_tag="BSU_14150" /old_locus_tag="BSU14150" /label="fldN gene" CDS 1374480..1375373 /gene="ykuO" /locus_tag="BSU_14160" /old_locus_tag="BSU14160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12354229, 24214949" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389299.1" /db_xref="EnsemblGenomes-Gn:BSU14160" /db_xref="EnsemblGenomes-Tr:CAB13289" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG13299" /db_xref="UniProtKB/Swiss-Prot:O34879" /translation="MFHKGATAVTASAFSGYFVAVQREGIFHYSLEQGWRKLFRLKSK IHCISYIGPYLFGVGEKGTVIRSADEGKTWTMSSFPTNATVWAITGRNNGFVCAHGKH CIYVSDDFGVSWRVAKPFAEFHNPPVIRSLCLHGGNLFIGTQIHEYFGGIWAYDIKRD TVQVVKKEKNRMTASMLVFNENWLVAAMGSVKGKHGAVTVRNLLNGEEFTIQSSMIRN EESFLDLSEDDGIIYVTTTQDENGFSRIYQVDLEARSLKWFDTIKGHGWRVANQKENF FCAGLYECKFVQPYEVSAMIH*" /label="ykuO CDS" gene 1374480..1375373 /gene="ykuO" /locus_tag="BSU_14160" /old_locus_tag="BSU14160" /label="ykuO gene" CDS 1375389..1375844 /gene="fldP" /locus_tag="BSU_14170" /old_locus_tag="BSU14170" /experiment="publication(s) with functional evidences, PMID:12354229, 15449930, 17127770, 20186410, 21665975, 24214949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15449930, 17127770, 20186410, 21665975, 24214949; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="short-chain flavodoxin" /protein_id="NP_389300.2" /db_xref="EnsemblGenomes-Gn:BSU14170" /db_xref="EnsemblGenomes-Tr:CAB13290" /db_xref="GOA:O34589" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001226" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010087" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13300" /db_xref="UniProtKB/Swiss-Prot:O34589" /translation="MAKILLVYATMSGNTEAMADLIEKGLQEALAEVDRFEAMDIDDA QLFTDYDHVIMGTYTWGDGDLPDEFLDLVEDMEEIDFSGKTCAVFGSGDTAYEFFCGA VDTLEAKIKERGGDIVLPSVKIENNPEGEEEEELINFGRQFAKKSGCAV*" /label="fldP CDS" gene 1375389..1375844 /gene="fldP" /locus_tag="BSU_14170" /old_locus_tag="BSU14170" /label="fldP gene" promotor_-10 complement(1375660..1375679) /Source="Nicolas_upshift_promotors" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1375673) /Source="Nicolas_upshifts" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1375693..1375701) /Source="Nicolas_upshift_promotors" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1375838 /Source="Nicolas_upshifts" /id="D792" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="6.48855" /MaxDrop="3.75748" /score="20.7202933" /energy="-9" /TU="U1168" /idTUdmin="U1165" /TUdmin=1957 /isTUend="FALSE" /label="downshifts" promotor_-35 1375883..1375890 /Source="Nicolas_upshift_promotors" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-35" promotor_-10 1375904..1375923 /Source="Nicolas_upshift_promotors" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-10" upshifts 1375905 /Source="Nicolas_upshifts" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="upshifts" CDS 1375949..1376659 /gene="dapH" /locus_tag="BSU_14180" /old_locus_tag="BSU14180" /EC_number="2.3.1.89" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:5411754, 10368155, 11910040, 12682299, 14627808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 5411754, 10368155, 11910040, 12682299, 14627808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tetrahydrodipicolinate N-acetyltransferase" /protein_id="NP_389301.2" /db_xref="EnsemblGenomes-Gn:BSU14180" /db_xref="EnsemblGenomes-Tr:CAB13291" /db_xref="GOA:O34981" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR013710" /db_xref="InterPro:IPR016036" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR019873" /db_xref="SubtiList:BG13301" /db_xref="UniProtKB/Swiss-Prot:O34981" /translation="MKMMDANEIISFIQNSTKSTPVKVYVKGELEGINFGESAKAFIN GNTGVVFGEWSEIQTAIEENQSKIEDYVVENDRRNSAIPMLDLKNIKARIEPGAIIRD QVEIGDNAVIMMGASINIGSVIGEGTMIDMNVVLGGRATVGKNCHIGAGSVLAGVIEP PSAKPVVIEDDVVIGANAVVLEGVTVGKGAVVAAGAIVVNDVEPYTVVAGTPAKKIKD IDEKTKGKTEIKQELRQL*" /label="dapH CDS" gene 1375949..1376659 /gene="dapH" /locus_tag="BSU_14180" /old_locus_tag="BSU14180" /label="dapH gene" downshifts complement(1375958) /Source="Nicolas_upshifts" /id="D793" /incds=0 /nref=60 /ntot=165 /MaxReadThrough="1.03272" /MaxDrop="4.75802" /score="28.9046709" /energy="-15" /TU="NA" /idTUdmin="U1171" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1376068..1376072) /Source="Nicolas_upshift_promotors" /id="U1171" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.005994005994006" /xcortree=40 /SigmaFactorBS="tgctgtttggatttcgctccattcaccgaaaacgacacCagt gtttccattgataaAAGCTttcgcagattcaccgaaattgattccttccagctcacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1376068) /Source="Nicolas_upshifts" /id="U1171" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.005994005994006" /xcortree=40 /SigmaFactorBS="tgctgtttggatttcgctccattcaccgaaaacgacacCagt gtttccattgataaAAGCTttcgcagattcaccgaaattgattccttccagctcacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1376729..1377853 /gene="dapI" /locus_tag="BSU_14190" /old_locus_tag="BSU14190" /EC_number="3.5.1.47" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14627808, 17093042, 24261876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14627808, 17093042, 24261876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-diaminopimelate deacetylase" /protein_id="NP_389302.1" /db_xref="EnsemblGenomes-Gn:BSU14190" /db_xref="EnsemblGenomes-Tr:CAB13292" /db_xref="GOA:O34916" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR023905" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13302" /db_xref="UniProtKB/Swiss-Prot:O34916" /translation="MKIEELIAIRRDLHRIPELGFQEFKTQQYLLNVLEQYPQDRIEI EKWRTGLFVKVNGTAPEKMLAYRADIDALSIEEQTGLPFASEHHGNMHACGHDLHMTI ALGIIDHFVHHPVKHDLLFLFQPAEEGPGGAEPMLESDVLKKWQPDFITALHIAPELP VGTIATKSGLLFANTSELVIDLEGKGGHAAYPHLAEDMVVAASTLVTQLQTIISRNTD PLDSAVITVGTITGGSAQNIIAETAHLEGTIRTLSEESMKQVKERIEDVVKGIEIGFR CKGKVTYPSVYHQVYNTSGLTEEFMSFVAEHQLATVIEAKEAMTGEDFGYMLKKYPGF MFWLGADSEHGLHHAKLNPDENAIETAVHVMTGYFSVYAN*" /label="dapI CDS" gene 1376729..1377853 /gene="dapI" /locus_tag="BSU_14190" /old_locus_tag="BSU14190" /label="dapI gene" promotor_-35 1377865..1377871 /Source="Nicolas_upshift_promotors" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1377885..1377896 /Source="Nicolas_upshift_promotors" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1377887 /Source="Nicolas_upshifts" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1377891..1377905) /Source="Nicolas_upshift_promotors" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1377915..1377919) /Source="Nicolas_upshift_promotors" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1377915..1378160 /gene="ykuS" /locus_tag="BSU_14200" /old_locus_tag="BSU14200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389303.1" /db_xref="EnsemblGenomes-Gn:BSU14200" /db_xref="EnsemblGenomes-Tr:CAB13293" /db_xref="InterPro:IPR005370" /db_xref="SubtiList:BG13303" /db_xref="UniProtKB/Swiss-Prot:O34783" /translation="MAKKIGIEQSLSDVEAALKEKGYDVVMMKSPADAQGCDCCVVTG LDNNVQGIADTVTQAPVITASGMTAEEICSEVESRIQ*" /label="ykuS CDS" gene 1377915..1378160 /gene="ykuS" /locus_tag="BSU_14200" /old_locus_tag="BSU14200" /label="ykuS gene" upshifts complement(1377916) /Source="Nicolas_upshifts" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1378148 /Source="Nicolas_upshifts" /id="D794" /incds=0 /nref=238 /ntot=269 /MaxReadThrough="3.49553" /MaxDrop="5.88829" /score="3.56597112" /energy="-9.9" /TU="U1172" /idTUdmin="U1168" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1378193..1379143 /Source="Nicolas_S_feature" /locus_tag="new_1491217_1492167" /HighExp="S4, S5, S6, S3, S7, S8, LoTm, BT, B36, G135" /AntisenseName="ykuT" /AntisenseCor="-0.479447808227356" /AntisenseRegPval="-16.100000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S518" CDS complement(1378197..1379000) /gene="mscT" /locus_tag="BSU_14210" /old_locus_tag="BSU14210" /function="16.6: Maintain" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12626684, 17665170, 18310427, 19252899, 21150093" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12626684, 17665170, 18310427, 19252899, 21150093; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small-conductance mechanosensitive channel" /protein_id="NP_389304.2" /db_xref="EnsemblGenomes-Gn:BSU14210" /db_xref="EnsemblGenomes-Tr:CAB13294" /db_xref="GOA:O34897" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="InterPro:IPR011066" /db_xref="SubtiList:BG13304" /db_xref="UniProtKB/Swiss-Prot:O34897" /translation="MDFIKQYDWAGLITNAGVLLIKLAIMILLYFIVRSLGMKIIKHL FAKFEEQNSLSIGRAHTLRSLTLNIFAYTLIFIFFVMVLDLFHYDPSALLAGAGIVGL AVGFGAQGLVSDIVTGFFILLEKQLDVGDYITVSTFDGIVEQVGLRTTQIRSFDGTLH YIPNRNITNVSNHSRGTMQALVDIKVPAERNIDEMIHILQQVCDETAAALPQIKEGPN VIGIQELGTSEIVIRVIAKTENMEQWRVERVLRKEIKNAFDRAFPKETE*" /label="mscT CDS" gene complement(1378197..1379000) /gene="mscT" /locus_tag="BSU_14210" /old_locus_tag="BSU14210" /label="mscT gene" downshifts complement(1378209) /Source="Nicolas_upshifts" /id="D795" /incds=0 /nref=16 /ntot=131 /MaxReadThrough="1.65551" /MaxDrop="4.4361" /score="29.0050313" /energy="-9.9" /TU="NA" /idTUdmin="U1174" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1379051..1379070) /Source="Nicolas_upshift_promotors" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1379060) /Source="Nicolas_upshifts" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1379084..1379091) /Source="Nicolas_upshift_promotors" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1379116..1379123 /Source="Nicolas_upshift_promotors" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="promotor_-35" promotor_-10 1379138..1379157 /Source="Nicolas_upshift_promotors" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="promotor_-10" S_feature 1379145..1379236 /Source="Nicolas_S_feature" /locus_tag="new_1492169_1492260" /HighExp="LPhT, Salt, Etha, M9-stat, M0t90, T4.0H, T5.0H, S4, Heat, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S519" upshifts 1379145 /Source="Nicolas_upshifts" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="upshifts" CDS 1379237..1379779 /gene="ahpA" /locus_tag="BSU_14220" /old_locus_tag="BSU14220" /EC_number="1.11.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:22938038, 27683249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22938038, 27683249; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biofilm-specific peroxidase; 2-cys peroxiredoxin" /protein_id="NP_389305.1" /db_xref="EnsemblGenomes-Gn:BSU14220" /db_xref="EnsemblGenomes-Tr:CAB13295" /db_xref="GOA:O34564" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR019479" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13305" /db_xref="UniProtKB/Swiss-Prot:O34564" /translation="MAERMVGKQAPRFEMEAVLASKEFGKVSLEENMKNDKWTVLFFY PMDFTFVCPTEITAMSDRYDEFEDLDAEVIGVSTDTIHTHLAWINTDRKENGLGQLKY PLAADTNHEVSREYGVLIEEEGVALRGLFIINPEGELQYQTVFHNNIGRDVDETLRVL QALQTGGLCPANWKPGQKTL*" /label="ahpA CDS" gene 1379237..1379779 /gene="ahpA" /locus_tag="BSU_14220" /old_locus_tag="BSU14220" /label="ahpA gene" CDS 1379851..1380297 /gene="ykuV" /locus_tag="BSU_14230" /old_locus_tag="BSU14230" /EC_number="1.8.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15937154, 16132829, 16418167" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15937154, 16132829, 16418167; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_389306.2" /db_xref="EnsemblGenomes-Gn:BSU14230" /db_xref="EnsemblGenomes-Tr:CAB13296" /db_xref="GOA:O31699" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:2B5X" /db_xref="PDB:2B5Y" /db_xref="SubtiList:BG13306" /db_xref="UniProtKB/Swiss-Prot:O31699" /translation="MKLRQPMPELTGEKAWLNGEVTREQLIGEKPTLIHFWSISCHLC KEAMPQVNEFRDKYQDQLNVVAVHMPRSEDDLDPGKIKETAAEHDITQPIFVDSDHAL TDAFENEYVPAYYVFDKTGQLRHFQAGGSGMKMLEKRVNRVLAETE*" /label="ykuV CDS" gene 1379851..1380297 /gene="ykuV" /locus_tag="BSU_14230" /old_locus_tag="BSU14230" /label="ykuV gene" downshifts 1380305 /Source="Nicolas_upshifts" /id="D796" /incds=0 /nref=58 /ntot=211 /MaxReadThrough="3.11112" /MaxDrop="4.73023" /score="10.8864177" /energy="-5.4" /TU="U1175" /idTUdmin="U1172" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1380690..1380697 /Source="Nicolas_upshift_promotors" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1380710 /Source="Nicolas_upshifts" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1380712..1380731 /Source="Nicolas_upshift_promotors" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1380763..1381338 /gene="rok" /locus_tag="BSU_14240" /old_locus_tag="BSU14240" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15743949, 15819619, 27902860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15819619, 27902860; Product type r: regulator" /codon_start=1 /transl_table=11 /product="repressor of comK" /protein_id="NP_389307.1" /db_xref="EnsemblGenomes-Gn:BSU14240" /db_xref="EnsemblGenomes-Tr:CAB13297" /db_xref="GOA:O34857" /db_xref="SubtiList:BG13307" /db_xref="UniProtKB/Swiss-Prot:O34857" /translation="MFNEREALRLRLEQLNEAEVKVIREYQIERDKIYAKLRELDRNG SPSEIKKDFRSEKKPDSLPVLAELAAQEIRSYQPQSQQQSVQPQLQSISSLPAGIPDG TTRRRRGTARPGSKAAKLREAAIKTLKRHNAAIKSSELQKEIEKESGLEIPNMTTFMQ SLIKMYPEVKKPYRGQYILEGEIESAESANE*" /label="rok CDS" gene 1380763..1381338 /gene="rok" /locus_tag="BSU_14240" /old_locus_tag="BSU14240" /label="rok gene" downshifts 1381316 /Source="Nicolas_upshifts" /id="D797" /incds=0 /nref=246 /ntot=258 /MaxReadThrough="1.77207" /MaxDrop="6.35121" /score="17.7584572" /energy="-9" /TU="NA" /idTUdmin="U1176" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1381379..1382344) /gene="sppO" /locus_tag="BSU_14250" /old_locus_tag="BSU14250" /experiment="publication(s) with functional evidences, PMID:8990290, 15383836, 15743949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990290, 15383836, 15743949; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore protein cse15" /protein_id="NP_389308.1" /db_xref="EnsemblGenomes-Gn:BSU14250" /db_xref="EnsemblGenomes-Tr:CAB13298" /db_xref="GOA:O31700" /db_xref="SubtiList:BG12251" /db_xref="UniProtKB/Swiss-Prot:O31700" /translation="MKRSGPFFHDVSQENLYLKSELSRCHKLISELEASYFHQKNNKL LKENTDMKEKLQQLSAELTHMSTKEKHASHTSQTLHQIRAELLDKIVVLQELLSAETY KRRAEIEEKHKLHIAKVKIEEENKNLHKRISELQASIEQEQNALLQAKQQAELIKAEN GRLKEQMVEKEYQLKHIKIEVDHMKDRIIETKERLLDIEKTKEKLFHETIISYKRQLD ESDAWIASHFADIDGGTKQKEKTEEEAPAAYAQPNHVETILEDVTKQIHVLQKQLAHA QSSDQAKSHTIEELKNRAAEEKPYQKWVYKLNLEKENKPSQKKPQ*" /label="sppO CDS" gene complement(1381379..1382344) /gene="sppO" /locus_tag="BSU_14250" /old_locus_tag="BSU14250" /label="sppO gene" downshifts complement(1381392) /Source="Nicolas_upshifts" /id="D798" /incds=0 /nref=47 /ntot=67 /MaxReadThrough="2.24884" /MaxDrop="5.5936" /score="3.60334458" /energy="-7.2" /TU="NA" /idTUdmin="U1178" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1381688..1381689 /Source="Nicolas_upshift_promotors" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1381707..1381726 /Source="Nicolas_upshift_promotors" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1381713..1382437 /Source="Nicolas_S_feature" /locus_tag="new_1494737_1495461" /HighExp="dia15, Diami, dia5, H2O2, G135, G150, G180, LBGexp, Paraq, Lbexp" /AntisenseName="yknT" /AntisenseCor="-0.36512493899072102" /AntisenseRegPval="-9.1999999999999993" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S520" upshifts 1381713 /Source="Nicolas_upshifts" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1382365..1382383) /Source="Nicolas_upshift_promotors" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1382386) /Source="Nicolas_upshifts" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1382398..1382403) /Source="Nicolas_upshift_promotors" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1382424..1382430 /Source="Nicolas_upshift_promotors" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1382440 /Source="Nicolas_upshifts" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1382444..1382463 /Source="Nicolas_upshift_promotors" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1382481..1383080 /gene="mobA" /locus_tag="BSU_14260" /old_locus_tag="BSU14260" /EC_number="2.7.7.77" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10978347; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin-guanine dinucleotide biosynthesis protein A" /protein_id="NP_389309.1" /db_xref="EnsemblGenomes-Gn:BSU14260" /db_xref="EnsemblGenomes-Tr:CAB13299" /db_xref="GOA:O31701" /db_xref="InterPro:IPR013482" /db_xref="InterPro:IPR025877" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12621" /db_xref="UniProtKB/Swiss-Prot:O31701" /translation="MKHVNVLLAGGASRRFGEPKAFVKWKGRMLYECAKEALGEQTVI ISRPEFIDRFQENGENEVYQDAEPFQGMGPLAGIYTAFKKTDGDLYTVLSCDTPLIQR RTMLELKRLMIAGADAVVPISDGQVQPLIAIYHKRIMPVLYDQLSEKRLRISDLLGRI SVCYVQAENIGANPAEFININTRDDFSCLEEKSNSLKRD*" /label="mobA CDS" gene 1382481..1383080 /gene="mobA" /locus_tag="BSU_14260" /old_locus_tag="BSU14260" /label="mobA gene" CDS 1383131..1384150 /gene="moeB" /locus_tag="BSU_14270" /old_locus_tag="BSU14270" /EC_number="2.7.7.80" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17223713; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin biosynthesis adenylyltransferase" /protein_id="NP_389310.1" /db_xref="EnsemblGenomes-Gn:BSU14270" /db_xref="EnsemblGenomes-Tr:CAB13300" /db_xref="GOA:O31702" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG12624" /db_xref="UniProtKB/Swiss-Prot:O31702" /translation="MEERYSRQIRFKQIGEEGQKRLADSHVLIVGAGALGTAGAEGLS RAGVGTITIIDRDYVEWSNLQRQQLYTESDAKLRMPKAMAAKEHLSAINSEIHIEAYV TEGTAETLEPLIEKADVVIDATDNFETRMLINDLAQKTKTPWVYGACVSSQGMFMTVI PGETPCLSCLFEQIPVGGATCDTAGIIPPAVHIVSAYQQAEALKLLTGQKEAIQRGFV TFDVWNNSHMKINVNHVRREECPSCGANAVYPYLQDWNTPKAAVLCGRDTVQVRSESL KRIPKQELIKRLKTIGKVEANAFLLHIFYEDFRIVIFNDGRALVHGTNDVKEANSVLA RVIGL*" /label="moeB CDS" gene 1383131..1384150 /gene="moeB" /locus_tag="BSU_14270" /old_locus_tag="BSU14270" /label="moeB gene" CDS 1384168..1385460 /gene="moeA" /locus_tag="BSU_14280" /old_locus_tag="BSU14280" /EC_number="2.10.1.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11428898, 12006571, 18959753, 21206014; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdate to molybdopterin ligation enzyme" /protein_id="NP_389311.1" /db_xref="EnsemblGenomes-Gn:BSU14280" /db_xref="EnsemblGenomes-Tr:CAB13301" /db_xref="GOA:O31703" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR005110" /db_xref="InterPro:IPR005111" /db_xref="InterPro:IPR036135" /db_xref="InterPro:IPR036425" /db_xref="InterPro:IPR036688" /db_xref="SubtiList:BG12623" /db_xref="UniProtKB/Swiss-Prot:O31703" /translation="MLEKRTPIPVDEAVRRVCHFQKQGETEWVALEDSLHRFLAEDIT ADHHVPAFDRSPYDGFAVRACDTAEASRENPVRFEVIDHIGAGAVSEKELGPFQAVRI MTGAQIPEGADAVVMIELTQAFEENGKSFMSLKRRFQTGDNISKTGEDAQKGSVLLTK GTRVTPGVTALLATFGYASVPVVRKPVVGIIATGTELLNVSDPLEPGKIRNSNASMVY AQAIEAGATPLYLGKISDELDKSFAAVKEAMKKVDFLITTGGVSVGDFDFLPAIYEKL GADVLFNKVAMRPGSVTTVAHANDMLLFGLSGNPSACYVGFELFVKPIIQTWLLNETP HSICAEAVLTKDFPKPNPFTRFVRALVHHQEGKLLATPVGLDKSSSVTSLADANAFII LPGGTRGYESGRTVQVLLIREENGSEWPWSVLSRSSKL*" /label="moeA CDS" gene 1384168..1385460 /gene="moeA" /locus_tag="BSU_14280" /old_locus_tag="BSU14280" /label="moeA gene" CDS 1385421..1385942 /gene="mobB" /locus_tag="BSU_14290" /old_locus_tag="BSU14290" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9219527, 12682065, 12719427; Product type c: carrier" /codon_start=1 /transl_table=11 /product="molybdopterin-guanine dinucleotide biosynthesis protein B" /protein_id="NP_389312.1" /db_xref="EnsemblGenomes-Gn:BSU14290" /db_xref="EnsemblGenomes-Tr:CAB13302" /db_xref="GOA:O31704" /db_xref="InterPro:IPR004435" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12622" /db_xref="UniProtKB/Swiss-Prot:O31704" /translation="MALVRPFPIVQVVGFQNSGKTTFIERILEKASEQGVHLGCLKHH GHGGEPQTLTEGKDTDRYKAAGADVTAVEGAGVLQLTARRNWDLARLIELYQFLETDC LLIEGFKKAPYPKVVILSEKEDLEALQAVNIIAIIYRKKEHMTEHQGLPVFHADDPVA VDFVLSQLKGESA*" /label="mobB CDS" gene 1385421..1385942 /gene="mobB" /locus_tag="BSU_14290" /old_locus_tag="BSU14290" /label="mobB gene" CDS 1385942..1386415 /gene="moaE" /locus_tag="BSU_14300" /old_locus_tag="BSU14300" /EC_number="2.8.1.12" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11135669, 18092812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin synthase (large subunit)" /protein_id="NP_389313.1" /db_xref="EnsemblGenomes-Gn:BSU14300" /db_xref="EnsemblGenomes-Tr:CAB13303" /db_xref="GOA:O31705" /db_xref="InterPro:IPR003448" /db_xref="InterPro:IPR036563" /db_xref="SubtiList:BG12620" /db_xref="UniProtKB/Swiss-Prot:O31705" /translation="MERFEITKTPINTENIIKKVEKREAGAITTFIGTVREWTNGKRT VRLEYEAYEPMAVQMLAQIGAEIEEKWEGASAAITHRIGVLDIGEAAVVIAVSSPHRK AAYEANEYAIERIKQIVPIWKKEIWEDGEQWIGDQLETTAYPNGKPDLSEGEQHD*" /label="moaE CDS" gene 1385942..1386415 /gene="moaE" /locus_tag="BSU_14300" /old_locus_tag="BSU14300" /label="moaE gene" CDS 1386408..1386641 /gene="moaD" /locus_tag="BSU_14310" /old_locus_tag="BSU14310" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11135669, 17223713, 19946146; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin synthase (small subunit)" /protein_id="NP_389314.1" /db_xref="EnsemblGenomes-Gn:BSU14310" /db_xref="EnsemblGenomes-Tr:CAB13304" /db_xref="GOA:O31706" /db_xref="InterPro:IPR003749" /db_xref="InterPro:IPR010034" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR016155" /db_xref="SubtiList:BG12619" /db_xref="UniProtKB/Swiss-Prot:O31706" /translation="MIKILLFAGLAEQAGTQAIEIDMEQATTDEIKASLKEQYGLESI DTAMIAVNESYVKENTSVSSGDTVAIIPPVSGG*" /label="moaD CDS" gene 1386408..1386641 /gene="moaD" /locus_tag="BSU_14310" /old_locus_tag="BSU14310" /label="moaD gene" downshifts 1386620 /Source="Nicolas_upshifts" /id="D799" /incds=0 /nref=87 /ntot=240 /MaxReadThrough="1.14308" /MaxDrop="5.73073" /score="32.0123217" /energy="-16.9" /TU="NA" /idTUdmin="U1177" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 1386686..1386691 /Source="Nicolas_upshift_promotors" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="promotor_-35" promotor_-10 1386708..1386726 /Source="Nicolas_upshift_promotors" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="promotor_-10" upshifts 1386716 /Source="Nicolas_upshifts" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="upshifts" S_feature 1386728..1386814 /Source="Nicolas_S_feature" /locus_tag="new_1499752_1499838" /HighExp="S4, S5, S3, T5.0H, T4.0H, Pyr, S6, T3.30H, M9-stat, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S521" promotor_-35 1386804..1386807 /Source="Nicolas_upshift_promotors" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1386816 /Source="Nicolas_upshifts" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1386822..1386841 /Source="Nicolas_upshift_promotors" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1386865..1388622 /gene="yknU" /locus_tag="BSU_14320" /old_locus_tag="BSU14320" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389315.1" /db_xref="EnsemblGenomes-Gn:BSU14320" /db_xref="EnsemblGenomes-Tr:CAB13305" /db_xref="GOA:O31707" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13241" /db_xref="UniProtKB/Swiss-Prot:O31707" /translation="METFKRLKMYYWPYRKVFMWSLLAMLLMTAITVVYPIILQITID EIVLGRQYQLAAWVSLGFIAVMVLKGMATFFHQYLGDMFGIKSVYRLRNGLYEKLQRL SFSYYDNAKTGDLMSRLTADVEGLRFFLSYGLAELIRFGLLVAISLSVMFYYSVPLTL VTIAVLPFLAVAVYRFDKRVHPAFRGIRKSFAKLNTKVQENISGINTVKSLSREDFQI STFNKANAEYRAQYLQTSSIWSAYFPLMEFIGNTCIVALLSYGGYLVMQNQLNPGELV AFFSLVNYMMWPIMNLGFVINMFSQAKASGERLLDILEKEEDITDHPHALHKQKLTGD VHFKNVSLAYGKEQTNALCNVSFEANSGKVIGLLGPTGSGKSSVTQLLTRFYSPVGGM ITIDHKPITDYSLKTLRSNIGVVLQESFLFSSTIRSNISYGRPDASMEDVIEAAKRAQ AHNFIMELPDGYDTMLGERGMGLSGGQKQRIAIARAICLNPSILILDDATSAVDMQTE HSIQLALKEVMKNRTTFIVAHRISSLKHADEILVFNKGRIRERGTHHELLEKGGYYKK IYDLQYRDVKMINEPHEVG*" /label="yknU CDS" gene 1386865..1388622 /gene="yknU" /locus_tag="BSU_14320" /old_locus_tag="BSU14320" /label="yknU gene" CDS 1388634..1390448 /gene="yknV" /locus_tag="BSU_14330" /old_locus_tag="BSU14330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389316.1" /db_xref="EnsemblGenomes-Gn:BSU14330" /db_xref="EnsemblGenomes-Tr:CAB13306" /db_xref="GOA:O31708" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13242" /db_xref="UniProtKB/Swiss-Prot:O31708" /translation="MKQAKKQGVLERFYYSSDEIIEKPFNWAQMWRLLSYVKPYRKTI LPLSFLTVLIGTAVKLVIPILIGVYVLDQAITGRNSELLIQLIFIISGLYVLNYAANV LRIRWMNQLGQHVIYDLRQHLFTHVQRLSHRFFDQRSAGSILVRIMNDINSLQELFTS GVINLLTDLLLLAGVIIILFTLSPELTIAIMVTLPIMFFISTSLRKKIRRSWQTVRLK QSKLNSHLNESIQGIRVTQAFTQEEENMAYFDGVNQENYESWREATRKNAMFRPLVEM TNAIGTAVLIWYGATLIMNETITIGVFVSFAFYLGMFWEPISRLGQVYNQLLMGMASS ERIFEFLDEQPNVKEKPNAIHNEKINGEISFEEVEFSYDEKRKALHAVSFSIPAGSTL ALVGHTGSGKTTIANLISRFYDAAGGTIKIDGIPIKDLSLASLRSQISIVLQDTFIFS GTIMENIRFGRPNASDEEVMKASQAVGADEFISDLAEGYATEVEERGSVLSAGQRQLI SFARALLADPAIIILDEATASIDTETEVKIQQALKTLLKGRTAVMIAHRLSTIRDADR IIVLDHGRKIEEGNHDQLLAKGGIYAGLVKAQYSTAIE*" /label="yknV CDS" gene 1388634..1390448 /gene="yknV" /locus_tag="BSU_14330" /old_locus_tag="BSU14330" /label="yknV gene" promotor_-10 complement(1389071..1389090) /Source="Nicolas_upshift_promotors" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1389081) /Source="Nicolas_upshifts" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1389105..1389112) /Source="Nicolas_upshift_promotors" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1390499..1390508 /Source="Nicolas_upshift_promotors" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1390520..1390535 /Source="Nicolas_upshift_promotors" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1390524 /Source="Nicolas_upshifts" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="upshifts" CDS 1390558..1391253 /gene="skiW" /locus_tag="BSU_14340" /old_locus_tag="BSU14340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of permease exporting the starvation-induced killing protein" /protein_id="NP_389317.1" /db_xref="EnsemblGenomes-Gn:BSU14340" /db_xref="EnsemblGenomes-Tr:CAB13307" /db_xref="GOA:O31709" /db_xref="InterPro:IPR006977" /db_xref="SubtiList:BG13243" /db_xref="UniProtKB/Swiss-Prot:O31709" /translation="METNVEKNSGTATEKPSLFGVITSPSVQFERIRERPAVWGPLLI VAAIIIVGAVLQSLGTDYSELLKSQDTQGLSAEQMETVATITKFGGMAGAIIGGIAAL FIAPLIYWLCVKVSGGVTTYKKMLSLSLFVSLISSLGLLVNGIVAFTTDVNPLYSTTS LAGIIPSDGALASVLNTFEIFSIWSFVLLAIGLHKTGGISKKAGWISAIILFGILVVF SLFSGLINSVAGA*" /label="skiW CDS" gene 1390558..1391253 /gene="skiW" /locus_tag="BSU_14340" /old_locus_tag="BSU14340" /label="skiW gene" CDS 1391258..1392391 /gene="skiX" /locus_tag="BSU_14350" /old_locus_tag="BSU14350" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11544226, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544226, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of efflux permease exporting the starvation-induced killing protein" /protein_id="NP_389318.1" /db_xref="EnsemblGenomes-Gn:BSU14350" /db_xref="EnsemblGenomes-Tr:CAB13308" /db_xref="GOA:O31710" /db_xref="InterPro:IPR006143" /db_xref="InterPro:IPR032317" /db_xref="SubtiList:BG13244" /db_xref="UniProtKB/Swiss-Prot:O31710" /translation="MKKVWIGIGIAVIVALFVGINIYRSAAPTSGSAGKEVQTGSVEE NEISSTVMVPGTLKFSNEQYVFYEADKGTLEDIKVKEGDKVKKGTALVTYTNEQLSLE KEQNQLTSESNRLQIDQIQEKLKALDSKERELEKQVGKKEAEKQIESERTELQMQKKT AEIELKQTELQRQSLANRVSDLEVKSEIEGTVISVNQEAASKKSDIQEPVIHIGNPKD LVVSGKLSEYDTLKVKKGQKVTLTSDVIQGKTWKGTVSAVGLVPDQQESAAAQGTEQA VQYPLQVKIKGNLPEGKPGFKFIMNIETDKRKANTLPSKAVKKEDDQYYVYTVKDGKA KRVDVKIGEVTDDLTEIKEGLTQDDQVILNPSDQVTDGMEVKS*" /label="skiX CDS" gene 1391258..1392391 /gene="skiX" /locus_tag="BSU_14350" /old_locus_tag="BSU14350" /label="skiX gene" CDS 1392392..1393084 /gene="skiY" /locus_tag="BSU_14360" /old_locus_tag="BSU14360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9987136, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of efflux permease exporting the starvation-induced killing protein (ATP-binding protein)" /protein_id="NP_389319.1" /db_xref="EnsemblGenomes-Gn:BSU14360" /db_xref="EnsemblGenomes-Tr:CAB13309" /db_xref="GOA:O31711" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13245" /db_xref="UniProtKB/Swiss-Prot:O31711" /translation="MIQLSNVRKSYQIGKETFDVLHSIDLDIHQGEYVSIMGPSGSGK STIMNIIGCLDRPTSGTYQLDGEDISSYKDKELAAVRNRSIGFVFQQFQLLPRLNAKK NVELPMIYSGIGKKERQERAERALEKVGLADRMLHMPNELSGGQKQRVAIARAIVNEP KLILADEPTGALDTKTSEAIMDQFTALNAEGTTIVLVTHEPEVADCTNRIVMVRDGNI VPASSGQRSVGE*" /label="skiY CDS" gene 1392392..1393084 /gene="skiY" /locus_tag="BSU_14360" /old_locus_tag="BSU14360" /label="skiY gene" CDS 1393081..1394274 /gene="skiZ" /locus_tag="BSU_14370" /old_locus_tag="BSU14370" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9987136, 22707703, 22720735, 27243566" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 22707703, 22720735, 27243566; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease subunit exporting Sporulation-Delaying Protein" /protein_id="NP_389320.1" /db_xref="EnsemblGenomes-Gn:BSU14370" /db_xref="EnsemblGenomes-Tr:CAB13310" /db_xref="GOA:O31712" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR005085" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG13246" /db_xref="UniProtKB/Swiss-Prot:O31712" /translation="MSLLENIRMALSSVLAHKMRSILTMLGIIIGVGSVIVVVAVGQG GEQMLKQSISGPGNTVELYYMPSDEELASNPNAAAESTFTENDIKGLKGIEGIKQVVA STSESMKARYHEEETDATVNGINDGYMNVNSLKIESGRTFTDNDFLAGNRVGIISQKM AKELFDKTSPLGEVVWINGQPVEIIGVLKKVTGLLSFDLSEMYVPFNMMKSSFGTSDF SNVSLQVESADDIKSAGKEAAQLVNDNHGTEDSYQVMNMEEIAAGIGKVTAIMTTIIG SIAGISLLVGGIGVMNIMLVSVTERTREIGIRKSLGATRGQILTQFLIESVVLTLIGG LVGIGIGYGGAALVSAIAGWPSLISWQVVCGGVLFSMLIGVIFGMLPANKAAKLDPIE ALRYE*" /label="skiZ CDS" gene 1393081..1394274 /gene="skiZ" /locus_tag="BSU_14370" /old_locus_tag="BSU14370" /label="skiZ gene" downshifts 1394252 /Source="Nicolas_upshifts" /id="D800" /incds=0 /nref=79 /ntot=210 /MaxReadThrough="3.49546" /MaxDrop="4.46952" /score="36.2703425" /energy="-12.1" /TU="U1183" /idTUdmin="U1183" /TUdmin="-396" /isTUend="FALSE" /label="downshifts" promotor_-35 1394323..1394329 /Source="Nicolas_upshift_promotors" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1394343..1394354 /Source="Nicolas_upshift_promotors" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1394351 /Source="Nicolas_upshifts" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1394396..1394403 /Source="Nicolas_upshift_promotors" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="promotor_-35" promotor_-10 1394418..1394437 /Source="Nicolas_upshift_promotors" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="promotor_-10" S_feature 1394423..1394514 /Source="Nicolas_S_feature" /locus_tag="new_1507447_1507538" /HighExp="UNK1, LPh, HPh, Fru, G180, MG 5, C30, G135, MG t5, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigWXY" /TUshortPSig="0.967, 0.86, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S522" upshifts 1394423 /Source="Nicolas_upshifts" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="upshifts" promotor_-35 1394478..1394485 /Source="Nicolas_upshift_promotors" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1394499..1394518 /Source="Nicolas_upshift_promotors" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1394516 /Source="Nicolas_upshifts" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="upshifts" CDS 1394554..1395309 /gene="fruR" /locus_tag="BSU_14380" /old_locus_tag="BSU14380" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14563858; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (DeoR family)" /protein_id="NP_389321.1" /db_xref="EnsemblGenomes-Gn:BSU14380" /db_xref="EnsemblGenomes-Tr:CAB13311" /db_xref="GOA:O31713" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12589" /db_xref="UniProtKB/Swiss-Prot:O31713" /translation="MLTPERHQLIIDQIEKHDVVKIQELINLTNASESTIRRDLSTLE ERGFLKRVHGGAAKLSDIRLEPDMLEKSSKNLHDKLKIAEKAASLLEEGDCIYLDAGT TTLHMIDFMDKTKDIVVVTNGVMHIDALIRKEISFYLLGGYVKHRTGAIIGGASLVAM DQYRFDKSFLGTNGVHTEAGFTTPDPDEALLKQKAIKQAKHAYVLADPSKFGEISFSA FAGIGDATIITTDAEELTFDNYQEKTVVKVVKP*" /label="fruR CDS" gene 1394554..1395309 /gene="fruR" /locus_tag="BSU_14380" /old_locus_tag="BSU14380" /label="fruR gene" upshifts complement(1394702) /Source="Nicolas_upshifts" /id="U1187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.74925074925075" /psig="0.015984015984016" /xcortree=3 /SigmaFactorBS="tcaagcatatcgggttcaagtctgatatcggaaagcttGgcc gctccaccatgaacGCGctttaaaaaaccgcgttcttcaagggtcgataaatctcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1394704..1394706) /Source="Nicolas_upshift_promotors" /id="U1187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.74925074925075" /psig="0.015984015984016" /xcortree=3 /SigmaFactorBS="tcaagcatatcgggttcaagtctgatatcggaaagcttGgcc gctccaccatgaacGCGctttaaaaaaccgcgttcttcaagggtcgataaatctcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1395306..1396217 /gene="fruK" /locus_tag="BSU_14390" /old_locus_tag="BSU14390" /EC_number="2.7.1.56" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 168069, 14563858, 24328040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1-phosphate kinase" /protein_id="NP_389322.1" /db_xref="EnsemblGenomes-Gn:BSU14390" /db_xref="EnsemblGenomes-Tr:CAB13312" /db_xref="GOA:O31714" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR017583" /db_xref="InterPro:IPR022463" /db_xref="InterPro:IPR023314" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG12588" /db_xref="UniProtKB/Swiss-Prot:O31714" /translation="MIYTVTLNPSVDYIVHVEDFTVGGLNRSSYDTKYPGGKGINVSR LLKRHHVASKALGFVGGFTGEYIKTFLREENLETAFSEVKGDTRINVKLKTGDETEIN GQGPTISDEDFKAFLEQFQSLQEGDIVVLAGSIPSSLPHDTYEKIAEACKQQNARVVL DISGEALLKATEMKPFLMKPNHHELGEMFGTAITSVEEAVPYGKKLVEQGAEHVIVSM AGDGALLFTNEAVYFANVPKGKLVNSVGAGDSVVAGFLAGISKQLPLEEAFRLGVTSG SATAFSEELGTEEFVQQLLPEVKVTRL*" /label="fruK CDS" gene 1395306..1396217 /gene="fruK" /locus_tag="BSU_14390" /old_locus_tag="BSU14390" /label="fruK gene" CDS 1396232..1398139 /gene="fruA" /locus_tag="BSU_14400" /old_locus_tag="BSU14400" /EC_number="2.7.1.202" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:118007, 200418" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 118007, 200418; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIABC component" /protein_id="NP_389323.1" /db_xref="EnsemblGenomes-Gn:BSU14400" /db_xref="EnsemblGenomes-Tr:CAB13313" /db_xref="GOA:P71012" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR003353" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR004715" /db_xref="InterPro:IPR006327" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013014" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="PDB:2R4Q" /db_xref="SubtiList:BG11938" /db_xref="UniProtKB/Swiss-Prot:P71012" /translation="MKITELLTKHTIKLNIESKEKENVIDEMVTVLDKAGKLNDRQAY KEAILNRESQSSTGIGEGIAIPHAKTASVINPAIAFGRSKDGVDYESLDGQPAHLVFM IAATEGANNTHLEALSRLSTLLMREEIRKQLLEAESEDAIIDIINQHDKDDDEEEEEE EAAPAPAGKGKILAVTACPTGIAHTFMAADALKEKAKELGVEIKVETNGSSGIKHKLT AQEIEDAPAIIVAADKQVEMERFKGKRVLQVPVTAGIRRPQELIEKAMNQDAPIYQGS GGGSAASNDDEEAKGKSGSGIGNTFYKHLMSGVSNMLPFVVGGGILVAISFFWGIHSA DPNDPSYNTFAAALNFIGGDNALKLIVAVLAGFIAMSIADRPGFAPGMVGGFMATQAN AGFLGGLIAGFLAGYVVILLKKVFTFIPQSLDGLKPVLIYPLFGIFITGVLMQFVVNT PVAAFMNFLTNWLESLGTGNLVLMGIILGGMMAIDMGGPLNKAAFTFGIAMIDAGNYA PHAAIMAGGMVPPLGIALATTIFRNKFTQRDREAGITCYFMGAAFVTEGAIPFAAADP LRVIPAAVVGAAVAGGLTEFFRVTLPAPHGGVFVAFITNHPMLYLLSIVIGAVVMAII LGIVKKPVTEK*" /label="fruA CDS" gene 1396232..1398139 /gene="fruA" /locus_tag="BSU_14400" /old_locus_tag="BSU14400" /label="fruA gene" downshifts 1398124 /Source="Nicolas_upshifts" /id="D801" /incds=0 /nref=133 /ntot=228 /MaxReadThrough="3.99928" /MaxDrop="5.27169" /score="11.7516734" /energy="-11.4" /TU="U1185" /idTUdmin="U1186" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1398208..1398215 /Source="Nicolas_upshift_promotors" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1398226..1398245 /Source="Nicolas_upshift_promotors" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1398229 /Source="Nicolas_upshifts" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="upshifts" CDS 1398284..1398865 /gene="sipT" /locus_tag="BSU_14410" /old_locus_tag="BSU14410" /EC_number="3.4.21.89" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9325333, 10198007, 11283286, 11807061, 12897006, 27159567" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 10198007, 11283286, 11807061, 12897006, 27159567; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_389324.1" /db_xref="EnsemblGenomes-Gn:BSU14410" /db_xref="EnsemblGenomes-Tr:CAB13314" /db_xref="GOA:P71013" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG11977" /db_xref="UniProtKB/Swiss-Prot:P71013" /translation="MTEEKNTNTEKTAKKKTNTYLEWGKAIVIAVLLALLIRHFLFEP YLVEGSSMYPTLHDGERLFVNKTVNYIGELKRGDIVIINGETSKIHYVKRLIGKPGET VQMKDDTLYINGKKVAEPYLSKNKKEAEKLGVSLTGDFGPVKVPKGKYFVMGDNRLNS MDSRNGLGLIAEDRIVGTSKFVFFPFNEMRQTK*" /label="sipT CDS" gene 1398284..1398865 /gene="sipT" /locus_tag="BSU_14410" /old_locus_tag="BSU14410" /label="sipT gene" downshifts 1398850 /Source="Nicolas_upshifts" /id="D802" /incds=0 /nref=90 /ntot=226 /MaxReadThrough="3.7981" /MaxDrop="6.13957" /score="5.03270493" /energy="-9.8" /TU="U1188" /idTUdmin="U1188" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 1398894 /Source="Nicolas_upshifts" /id="D803" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="2.6676" /MaxDrop="3.60225" /score="5.03270493" /energy="-9.8" /TU="NA" /idTUdmin="U1188" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1398899..1399168) /gene="ykoA" /locus_tag="BSU_14420" /old_locus_tag="BSU14420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_389325.1" /db_xref="EnsemblGenomes-Gn:BSU14420" /db_xref="EnsemblGenomes-Tr:CAB13315" /db_xref="GOA:O31715" /db_xref="SubtiList:BG13247" /db_xref="UniProtKB/Swiss-Prot:O31715" /translation="MRLLTLTEYCLLIFFTGFYLAVTGFTAKDIGLYIGIALIYIFSH IFSKRLLEKRGKENKQVHLFFSVLAIIGSVFITVLCIALVASFSK*" /label="ykoA CDS" gene complement(1398899..1399168) /gene="ykoA" /locus_tag="BSU_14420" /old_locus_tag="BSU14420" /label="ykoA gene" downshifts complement(1398904) /Source="Nicolas_upshifts" /id="D804" /incds=0 /nref=38 /ntot=254 /MaxReadThrough="2.08491" /MaxDrop="5.70938" /score="11.210199" /energy="-9.8" /TU="U1189" /idTUdmin="U1189" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" S_feature complement(1399169..1399234) /Source="Nicolas_S_feature" /locus_tag="new_1512193_1512258_c" /HighExp="LoTm, Gly, Lbstat, Sw, Cold, C30, HPh, S0, T0.30H, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S523" misc_feature complement(1399215..1399234) /Source="Nicolas_upshift_promotors" /id="U1189" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2176 /SigmaFactorBS="aagagaaatgattccctgataaaacagagagaaaacacttat acacccaaaccagccagcTGTGTTACAATTAAAGAGAGagaatgcatccgcctggaaa a" /listShort="S523, ykoA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1399234) /Source="Nicolas_upshifts" /id="U1189" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2176 /SigmaFactorBS="aagagaaatgattccctgataaaacagagagaaaacacttat acacccaaaccagccagcTGTGTTACAATTAAAGAGAGagaatgcatccgcctggaaa a" /listShort="S523, ykoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1399287..1399294 /Source="Nicolas_upshift_promotors" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1399305..1399324 /Source="Nicolas_upshift_promotors" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1399309 /Source="Nicolas_upshifts" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="upshifts" CDS 1399349..1400971 /gene="ykpA" /locus_tag="BSU_14430" /old_locus_tag="BSU14430" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10816464, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_389326.1" /db_xref="EnsemblGenomes-Gn:BSU14430" /db_xref="EnsemblGenomes-Tr:CAB13316" /db_xref="GOA:O31716" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG13270" /db_xref="UniProtKB/Swiss-Prot:O31716" /translation="MIAVNNVSLRFADRKLFEDVNIKFTPGNCYGLIGANGAGKSTFL KVLSGEIEPQTGDVHMSPGERLAVLKQNHFEYEEYEVLKVVIMGHKRLYEVMQEKDAI YMKPDFSDEDGIRAAELEGEFAELNGWEAESEAAILLKGLGISEDLHTKKMADLGGSE KVKVLLAQALFGKPDVLLLDEPTNHLDLQAIQWLEEFLINFENTVIVVSHDRHFLNKV CTHIADLDFNKIQIYVGNYDFWYESSQLALKLSQEANKKKEEQIKQLQEFVARFSANA SKSKQATSRKKLLEKITLDDIKPSSRRYPYVNFTPEREIGNDVLRVEGLTKTIDGVKV LDNVSFIMNREDKIAFTGRNELAVTTLFKIISGEMEADSGTFKWGVTTSQAYFPKDNS EYFEGSDLNLVDWLRQYSPHDQSESFLRGFLGRMLFSGEEVHKKANVLSGGEKVRCML SKAMLSGANILILDEPTNHLDLESITALNNGLISFKGAMLFTSHDHQFVQTIANRIIE ITPNGIVDKQMSYDEFLENADVQKKLTELYAE*" /label="ykpA CDS" gene 1399349..1400971 /gene="ykpA" /locus_tag="BSU_14430" /old_locus_tag="BSU14430" /label="ykpA gene" downshifts 1400959 /Source="Nicolas_upshifts" /id="D805" /incds=0 /nref=45 /ntot=239 /MaxReadThrough="5.13671" /MaxDrop="3.6227" /score="17.6386925" /energy="-7.6" /TU="U1190" /idTUdmin="U1190" /TUdmin="-993" /isTUend="FALSE" /label="downshifts" CDS 1401028..1401939 /gene="panE" /locus_tag="BSU_14440" /old_locus_tag="BSU14440" /EC_number="1.1.1.169" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1844812, 15966718, 17229734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-dehydropantoate reductase" /protein_id="NP_389327.1" /db_xref="EnsemblGenomes-Gn:BSU14440" /db_xref="EnsemblGenomes-Tr:CAB13317" /db_xref="GOA:O31717" /db_xref="InterPro:IPR003710" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR013332" /db_xref="InterPro:IPR013752" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13271" /db_xref="UniProtKB/Swiss-Prot:O31717" /translation="MKFLVVGAGGVGGYIGGRLSEKGNDVTFLVRQKRAEQLKKTGLV IHSEKGNVSFQPELISAGETGQFDVVIIASKAYSLGQVIEDVKPFIHQESVIIPFLNG YRHYEQLFAAFSKEQVLGGLCFIESALDNKGEIHHTSASHRFVFGEWNGERTERIRAL EEAFSGVKAEVIISGHIEKDIWKKYLFIAAQAGITTLFQRPLGPILATEAGRHTAQTL IGEICTVLRKEGVPADPALEEESFRTMTSMSYHMKSSMLRDMENGQTTEGDHLHGFLI EKAKRLSLAAPVLETVYANLQMYEAEK*" /label="panE CDS" gene 1401028..1401939 /gene="panE" /locus_tag="BSU_14440" /old_locus_tag="BSU14440" /label="panE gene" downshifts 1401944 /Source="Nicolas_upshifts" /id="D806" /incds=0 /nref=120 /ntot=228 /MaxReadThrough="2.04919" /MaxDrop="4.55439" /score="11.4959806" /energy="-9.6" /TU="NA" /idTUdmin="U1190" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(1401973..1403205) /gene="ampS" /locus_tag="BSU_14450" /old_locus_tag="BSU14450" /EC_number="3.4.11.24" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9362117, 16088219, 22808738" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9362117, 16088219, 22808738; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminopeptidase" /protein_id="NP_389328.1" /db_xref="EnsemblGenomes-Gn:BSU14450" /db_xref="EnsemblGenomes-Tr:CAB13318" /db_xref="GOA:P39762" /db_xref="InterPro:IPR000787" /db_xref="InterPro:IPR035097" /db_xref="SubtiList:BG10986" /db_xref="UniProtKB/Swiss-Prot:P39762" /translation="MDSFSQKLNTYAQLAVEVGVNVQKGQYVVVNASTDVRDFVRLIV KHAYEKGAKNVTVNWQDDEVAKLKYELAPFEAFEEYPEWEAKGREELAKNGAAFISVV SSNPDLLKGIDSKRIAAFQKAAGKALHTYRQYIQSDKVSWTVVGAASAGWAHKVFPGK SEEEAIHLLWEEIFKATRVNEDNPVQAWINHDQNLHEKVDHLNERHYAALHYQAEGTD LTIKLPRKHVWAGAGSVNESGHEFMANMPTEEVFTLPQKDGVDGVVSSTKPLSYGGNI IENFTLTFENGRIVDIKAEKGEDILKELVETDEGSHYLGEVALVPYDSPISQSNILFY NTLFDENASNHLAIGSAYAFNIEGGKQMSREELVKEGLNESITHVDFMIGSKDMNIDG ITADGKREPIFRNGNWAF*" /label="ampS CDS" gene complement(1401973..1403205) /gene="ampS" /locus_tag="BSU_14450" /old_locus_tag="BSU14450" /label="ampS gene" downshifts complement(1401984) /Source="Nicolas_upshifts" /id="D807" /incds=0 /nref=215 /ntot=254 /MaxReadThrough="1.34101" /MaxDrop="5.7635" /score="40.7811053" /energy="-9.6" /TU="NA" /idTUdmin="U1191" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1403223..1403242) /Source="Nicolas_upshift_promotors" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1403247) /Source="Nicolas_upshifts" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1403257..1403262) /Source="Nicolas_upshift_promotors" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1403315..1403449) /gene="ykpC" /locus_tag="BSU_14460" /old_locus_tag="BSU14460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389329.1" /db_xref="EnsemblGenomes-Gn:BSU14460" /db_xref="EnsemblGenomes-Tr:CAB13319" /db_xref="InterPro:IPR035379" /db_xref="SubtiList:BG11812" /db_xref="UniProtKB/Swiss-Prot:Q45492" /translation="MLRDLGRRVAIAAILSGIILGGMSISLANMPHSPAGGTVKLNHP *" /label="ykpC CDS" gene complement(1403315..1403449) /gene="ykpC" /locus_tag="BSU_14460" /old_locus_tag="BSU14460" /label="ykpC gene" downshifts complement(1403326) /Source="Nicolas_upshifts" /id="D808" /incds=0 /nref=51 /ntot=151 /MaxReadThrough="3.10365" /MaxDrop="5.04142" /score="-2.2377884" /energy="-9.1" /TU="U1192" /idTUdmin="U1193" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1403471..1403489) /Source="Nicolas_upshift_promotors" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1403482) /Source="Nicolas_upshifts" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1403484..1403549) /Source="Nicolas_S_feature" /locus_tag="new_1516508_1516573_c" /HighExp="HiTm, C30, Lbstat, MG-0.2, BC, G135, MG 15, MG 10, MG-0.1, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S524" promotor_-35 complement(1403505..1403510) /Source="Nicolas_upshift_promotors" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1403550..1404557) /gene="mreBH" /locus_tag="BSU_14470" /old_locus_tag="BSU14470" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16950129, 19643765, 19659933, 21091501, 21636651, 26091431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16950129, 19643765, 19659933, 21091501, 21636651, 26091431; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_389330.1" /db_xref="EnsemblGenomes-Gn:BSU14470" /db_xref="EnsemblGenomes-Tr:CAB13320" /db_xref="GOA:P39763" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10987" /db_xref="UniProtKB/Swiss-Prot:P39763" /translation="MFQSTEIGIDLGTANILVYSKNKGIILNEPSVVAVDTTTKAVLA IGADAKNMIGKTPGKIVAVRPMKDGVIADYDMTTDLLKHIMKKAAKSIGMSFRKPNVV VCTPSGSTAVERRAISDAVKNCGAKNVHLIEEPVAAAIGADLPVDEPVANVVVDIGGG TTEVAIISFGGVVSCHSIRIGGDQLDEDIVSFVRKKYNLLIGERTAEQVKMEIGHALI EHIPEAMEIRGRDLVTGLPKTIMLQSNEIQDAMRESLLHILEAIRATLEDCPPELSGD IVDRGVILTGGGALLNGIKEWLTEEIVVPVHVAQNPLESVAIGTGRSLEVIDKLQKAI K*" /label="mreBH CDS" gene complement(1403550..1404557) /gene="mreBH" /locus_tag="BSU_14470" /old_locus_tag="BSU14470" /label="mreBH gene" upshifts complement(1404603) /Source="Nicolas_upshifts" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1404604..1404612) /Source="Nicolas_upshift_promotors" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1404626..1404634) /Source="Nicolas_upshift_promotors" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1404744..1404753 /Source="Nicolas_upshift_promotors" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="promotor_-35" upshifts 1404765 /Source="Nicolas_upshifts" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="upshifts" promotor_-10 1404766..1404781 /Source="Nicolas_upshift_promotors" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="promotor_-10" S_feature 1404768..1404840 /Source="Nicolas_S_feature" /locus_tag="new_1517792_1517864" /HighExp="Lbexp, dia5, LBGexp, dia0, Lbtran, Mt0, Oxctl, Paraq, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.88" /TUlongSig="NA" /TUlongPSig="NA" /label="S525" CDS 1404841..1405119 /gene="abhA" /locus_tag="BSU_14480" /old_locus_tag="BSU14480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16159768, 17720793, 19767430, 20817675, 20844865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16159768, 17720793, 19767430, 20817675, 20844865; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_389331.1" /db_xref="EnsemblGenomes-Gn:BSU14480" /db_xref="EnsemblGenomes-Tr:CAB13321" /db_xref="GOA:P39758" /db_xref="InterPro:IPR007159" /db_xref="PDB:2FY9" /db_xref="PDB:2RO3" /db_xref="SubtiList:BG10988" /db_xref="UniProtKB/Swiss-Prot:P39758" /translation="MKSIGVVRKVDELGRIVMPIELRRALDIAIKDSIEFFVDGDKII LKKYKPHGVCLMTGEITSENKEYGNGKITLSPEGAQLLLEEIQAALKE*" /label="abhA CDS" gene 1404841..1405119 /gene="abhA" /locus_tag="BSU_14480" /old_locus_tag="BSU14480" /label="abhA gene" downshifts 1405117 /Source="Nicolas_upshifts" /id="D809" /incds=0 /nref=61 /ntot=238 /MaxReadThrough="4.68201" /MaxDrop="5.62457" /score="7.91393519" /energy="-11" /TU="U1194" /idTUdmin="U1194" /TUdmin="-135" /isTUend="FALSE" /label="downshifts" S_feature complement(1405151..1406780) /Source="Nicolas_S_feature" /locus_tag="new_1518175_1519804_c" /HighExp="S6, S8, S5, LoTm, S4, S7, S3, C30, T5.0H, BT" /AntisenseName="kinC" /AntisenseCor="-0.76370141168998495" /AntisenseRegPval="-51.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S526" S_feature 1405162..1405266 /Source="Nicolas_S_feature" /locus_tag="new_1518186_1518290" /HighExp="Oxctl, Lbexp, LBGexp, H2O2, dia0, Paraq, G180, G150, G135, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.88" /TUlongSig="NA" /TUlongPSig="NA" /label="S527" downshifts complement(1405174) /Source="Nicolas_upshifts" /id="D810" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="0.833919999999999" /MaxDrop="3.11258" /score="8.02057524" /energy="-11" /TU="NA" /idTUdmin="U1196" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1405248..1405255 /Source="Nicolas_upshift_promotors" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1405267..1405286 /Source="Nicolas_upshift_promotors" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1405268 /Source="Nicolas_upshifts" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="upshifts" CDS 1405309..1406595 /gene="kinC" /locus_tag="BSU_14490" /old_locus_tag="BSU14490" /EC_number="2.7.13.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11069677, 11673427, 7836330, 20971918, 25701730, 26152584, 23569226, 26297017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 11673427, 7836330, 20971918, 25701730, 26152584, 23569226, 26297017; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component sensor potassium-responsive histidine kinase regulating cannibalism and biofilm formation" /protein_id="NP_389332.1" /db_xref="EnsemblGenomes-Gn:BSU14490" /db_xref="EnsemblGenomes-Tr:CAB13322" /db_xref="GOA:P39764" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10989" /db_xref="UniProtKB/Swiss-Prot:P39764" /translation="MRKYQARIISIILAMIFIMFWDYLFYFIGKNPINWPVDIVYTAV TLVSVWMLAYYIDEKQQLVKKMKDNEWKYKQLSEEKNRIMDNLQEIVFQTNAKGEITY LNQAWASITGFSISECMGTMYNDYFIKEKHVADHINTQIQNKASSGMFTAKYVTKNGT IFWGEVHYKLYYDRDDQFTGSLGTMSDITERKEAEDELIEINERLARESQKLSITSEL AAGIAHEVRNPLTSVSGFLQIMKTQYPDRKDYFDIIFSEIKRIDLVLSELLLLAKPQA ITFKTHQLNEILKQVTTLLDTNAILSNIVIEKNFKETDGCMINGDENQLKQVFINIIK NGIEAMPKGGVVTISTAKTASHAVISVKDEGNGMPQEKLKQIGKPFYSTKEKGTGLGL PICLRILKEHDGELKIESEAGKGSVFQVVLPLKSDS*" /label="kinC CDS" gene 1405309..1406595 /gene="kinC" /locus_tag="BSU_14490" /old_locus_tag="BSU14490" /label="kinC gene" CDS 1406611..1407444 /gene="ykqA" /locus_tag="BSU_14500" /old_locus_tag="BSU14500" /EC_number="2.3.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28537416; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative gamma-glutamylcyclotransferase (bacillithiol degradation)" /protein_id="NP_389333.1" /db_xref="EnsemblGenomes-Gn:BSU14500" /db_xref="EnsemblGenomes-Tr:CAB13323" /db_xref="GOA:P39759" /db_xref="InterPro:IPR009288" /db_xref="InterPro:IPR013024" /db_xref="InterPro:IPR036568" /db_xref="PDB:2QIK" /db_xref="SubtiList:BG10990" /db_xref="UniProtKB/Swiss-Prot:P39759" /translation="MNSLLFVYGTLRKHEKNHHLLAQSACINEQARTKGSLFAAKEGP TVVFNDEDEGYIYGEVYEADELCIHKLDQFFQGYHKQTVFVETDVGIKIALIYFMNKD GCAGFTKISSGDWKEHQMISKSKNPIYYFAYGSCMDNARFQKAGVDHYFQDPVGRAVL KGYTTRFTLKREDGSRADMLEDGGTTEGVLYRIPYSALSYLYKREGVESLTYRPAFVD VEAGGRHYKDCLTFLVLQKEAEIAPPQHYQIEIERGAELYLSPEFTEKLKRHMNSLPK G*" /label="ykqA CDS" gene 1406611..1407444 /gene="ykqA" /locus_tag="BSU_14500" /old_locus_tag="BSU14500" /label="ykqA gene" promotor_-10 complement(1406777..1406795) /Source="Nicolas_upshift_promotors" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1406792) /Source="Nicolas_upshifts" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1406811..1406816) /Source="Nicolas_upshift_promotors" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1407507..1408172 /gene="ktrC" /locus_tag="BSU_14510" /old_locus_tag="BSU14510" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 22720735, 23963175, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 22720735, 23963175, 28420751; Product type t : transporter" /codon_start=1 /transl_table=11 /product="potassium uptake protein" /protein_id="NP_389334.1" /db_xref="EnsemblGenomes-Gn:BSU14510" /db_xref="EnsemblGenomes-Tr:CAB13324" /db_xref="GOA:P39760" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG10991" /db_xref="UniProtKB/Swiss-Prot:P39760" /translation="MKKEFAVIGLGRFGGSICKALSEEGVEVMAMDIDEDKVNEYAKI ASHAVIGDSTDESVLKNLGLRNFDHVIVAIGENIQASILTTLILKELGVHTITVKAQN DYHEKVLSKIGADHIVHPERDMAKRIAHNIVSNNVLDYLELSEEHSLVEIVANSRLAG NTLLDLDIRAKYGINIVAIKRGKEVIVSPLATEVIHQEDILIVIGSVTDISRFEKRVL HTK*" /label="ktrC CDS" gene 1407507..1408172 /gene="ktrC" /locus_tag="BSU_14510" /old_locus_tag="BSU14510" /label="ktrC gene" downshifts 1408156 /Source="Nicolas_upshifts" /id="D811" /incds=0 /nref=191 /ntot=256 /MaxReadThrough="3.15176" /MaxDrop="5.50828" /score="4.60161255" /energy="-8.2" /TU="U1195" /idTUdmin="U1195" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 1408263..1408269 /Source="Nicolas_upshift_promotors" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1408284..1408303) /Source="Nicolas_upshift_promotors" /id="U1198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.584415584415584" /psig="0.985014985014985" /xcortree=1841 /SigmaFactorBS="ttcagcctattgactagcgcttctttattcaaataggcccct cctttttttattaTATGGTACAATATGCTATCGgaacgcctgtgcttagtcaatgaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1408284..1408303 /Source="Nicolas_upshift_promotors" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1408296 /Source="Nicolas_upshifts" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1408298) /Source="Nicolas_upshifts" /id="U1198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.584415584415584" /psig="0.985014985014985" /xcortree=1841 /SigmaFactorBS="ttcagcctattgactagcgcttctttattcaaataggcccct cctttttttattaTATGGTACAATATGCTATCGgaacgcctgtgcttagtcaatgaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1408327..1410060 /gene="adeC" /locus_tag="BSU_14520" /old_locus_tag="BSU14520" /EC_number="3.5.4.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 8550522, 17183219" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 8550522, 17183219; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenine deaminase" /protein_id="NP_389335.2" /db_xref="EnsemblGenomes-Gn:BSU14520" /db_xref="EnsemblGenomes-Tr:CAB13325" /db_xref="GOA:P39761" /db_xref="InterPro:IPR006679" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR026912" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG11044" /db_xref="UniProtKB/Swiss-Prot:P39761" /translation="MNKEALVNRLNASAKRQKADIVIKNGKIMDVYNQEWIYEDIAIT DGVIVGLGEYEGENIIDAEGQMIVPGFIDGHVHIESSMVTPIEFAKAVLPHGVTTVVT DPHEIANVSGEKGIEFMLEQARHTPLNIHFMLPSSVPAASFERSGAILKAADLKPFYE EEEVLGLAEVMDYVSVQQAEKDMVQKLLDARVAGKRIDGHLAGLSTDLINIYRTAFVL NDHEVTSKEEALDRIRRGMYVMMREGSVAKNTLNVLPAVNEKNARRFFFCTDDKHVDD LLSEGSVNHQVKMAIQAGLNPFLAYQLGSLNAAECYGLDTKGAIAPGFDADLLFVSDL ENVTVTMTMVKGQTVAEDSKAVYQDHASTAAPDQALLDSVKLAAPLNKQDFHMPIDSE QQINVIQIIPNQLETRLVQVPAPVAREFEPDTELDLLKIAVVERHKGLKETGLGVVKG FGFKSGAIATTISHDSHNIIAVGTNDEDIAAAVNKLQEIGGGLTIIKNGEELHSVPLP IAGLLSDQSAEQVNQSLLTLHDKLSLIGFTGGFNPFLTLSFLALPVIPDIKMTTTGLF DVKSFQHISLQ*" /label="adeC CDS" gene 1408327..1410060 /gene="adeC" /locus_tag="BSU_14520" /old_locus_tag="BSU14520" /label="adeC gene" S_feature complement(1409455..1410059) /Source="Nicolas_S_feature" /locus_tag="new_1522479_1523083_c" /HighExp="Etha, C30, C90, dia15, LBGexp, Cold, dia5, S8, G180, S7" /AntisenseName="adeC" /AntisenseCor="-9.8927927273806792E-3" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S528" downshifts 1410049 /Source="Nicolas_upshifts" /id="D812" /incds=0 /nref=51 /ntot=223 /MaxReadThrough="1.93923" /MaxDrop="6.63088" /score="44.3452043" /energy="-19.5" /TU="NA" /idTUdmin="U1197" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1410094..1411761) /gene="rnjA" /locus_tag="BSU_14530" /old_locus_tag="BSU14530" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 15831787, 17005971, 17229210, 17512403, 18713320, 19850915, 21893285, 21893286, 20025672, 22720735, 23504012, 24187087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15831787, 17005971, 17229210, 17512403, 18713320, 19850915, 21893285, 21893286, 20025672, 22720735, 23504012, 24187087; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease J1" /protein_id="NP_389336.1" /db_xref="EnsemblGenomes-Gn:BSU14530" /db_xref="EnsemblGenomes-Tr:CAB13326" /db_xref="GOA:Q45493" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR001587" /db_xref="InterPro:IPR004613" /db_xref="InterPro:IPR011108" /db_xref="InterPro:IPR030854" /db_xref="InterPro:IPR036866" /db_xref="PDB:3ZQ4" /db_xref="SubtiList:BG11813" /db_xref="UniProtKB/Swiss-Prot:Q45493" /translation="MKFVKNDQTAVFALGGLGEIGKNTYAVQFQDEIVLIDAGIKFPE DELLGIDYVIPDYTYLVKNEDKIKGLFITHGHEDHIGGIPYLLRQVNIPVYGGKLAIG LLRNKLEEHGLLRQTKLNIIGEDDIVKFRKTAVSFFRTTHSIPDSYGIVVKTPPGNIV HTGDFKFDFTPVGEPANLTKMAEIGKEGVLCLLSDSTNSENPEFTMSERRVGESIHDI FRKVDGRIIFATFASNIHRLQQVIEAAVQNGRKVAVFGRSMESAIEIGQTLGYINCPK NTFIEHNEINRMPANKVTILCTGSQGEPMAALSRIANGTHRQISINPGDTVVFSSSPI PGNTISVSRTINQLYRAGAEVIHGPLNDIHTSGHGGQEEQKLMLRLIKPKFFMPIHGE YRMQKMHVKLATDCGIPEENCFIMDNGEVLALKGDEASVAGKIPSGSVYIDGSGIGDI GNIVLRDRRILSEEGLVIVVVSIDMDDFKISAGPDLISRGFVYMRESGDLINDAQELI SNHLQKVMERKTTQWSEIKNEITDTLAPFLYEKTKRRPMILPIIMEV*" /label="rnjA CDS" gene complement(1410094..1411761) /gene="rnjA" /locus_tag="BSU_14530" /old_locus_tag="BSU14530" /label="rnjA gene" downshifts complement(1410104) /Source="Nicolas_upshifts" /id="D813" /incds=0 /nref=149 /ntot=269 /MaxReadThrough="4.3738" /MaxDrop="8.12983" /score="37.2074215" /energy="-19.5" /TU="U1199" /idTUdmin="U1200" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1411767..1411976) /gene="rnpZA" /locus_tag="BSU_14540" /old_locus_tag="BSU14540" /function="9.2: DNA-dependent RNA polymerase" /experiment="publication(s) with functional evidences, PMID:18289874, 24187087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18289874, 24187087; Product type f: factor" /codon_start=1 /transl_table=11 /product="omega 1 subunit of RNA polymerase" /protein_id="NP_389337.1" /db_xref="EnsemblGenomes-Gn:BSU14540" /db_xref="EnsemblGenomes-Tr:CAB13327" /db_xref="InterPro:IPR009907" /db_xref="SubtiList:BG13335" /db_xref="UniProtKB/Swiss-Prot:O31718" /translation="MIYKVFYQEKADEVPVREKTDSLYIEGVSERDVRTKLKEKKFNI EFITPVDGAFLEYEQQSENFKVLEL*" /label="rnpZA CDS" gene complement(1411767..1411976) /gene="rnpZA" /locus_tag="BSU_14540" /old_locus_tag="BSU14540" /label="rnpZA gene" promotor_-10 complement(1412013..1412032) /Source="Nicolas_upshift_promotors" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1412035) /Source="Nicolas_upshifts" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1412037..1412214) /Source="Nicolas_S_feature" /locus_tag="new_1525061_1525238_c" /HighExp="S5, S8, S7, S6, S4, ferm, nit, T5.0H, HiTm, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.97062099999999996" /TUshortSig="SigGF" /TUshortPSig="0.828" /TUlongSig="NA" /TUlongPSig="NA" /label="S529" promotor_-35 complement(1412047..1412050) /Source="Nicolas_upshift_promotors" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1412215) /Source="Nicolas_upshifts" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1412217..1412228) /Source="Nicolas_upshift_promotors" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1412242..1412248) /Source="Nicolas_upshift_promotors" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1412287..1412294 /Source="Nicolas_upshift_promotors" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1412308..1412327 /Source="Nicolas_upshift_promotors" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1412324 /Source="Nicolas_upshifts" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="upshifts" CDS 1412362..1413135 /gene="ykrA" /locus_tag="BSU_14550" /old_locus_tag="BSU14550" /EC_number="3.1.3.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389338.1" /db_xref="EnsemblGenomes-Gn:BSU14550" /db_xref="EnsemblGenomes-Tr:CAB13328" /db_xref="GOA:Q45494" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11814" /db_xref="UniProtKB/Swiss-Prot:Q45494" /translation="MDSKLIFFDIDGTIYDHDKNIPESTRKTVAELQRQGHHVFIASG RSPFLVKPILEELGIHSFISYNGQFVVFENQVIYKNPLPENAIRRLLKQADEGKHPVV FMAEDTMKATVADHPHVLEGIGSLKTDYPETDDLFYEGKEIFQLLLFCQDEEEKAYAA FPEFDLVRWHELSTDVLPHGGSKAEGIKKVIERLPFDIGDTYAFGDGLNDLQMIEYVG TGVAMGNAVPELKEIADFVTKPVDEDGIAYAVKELGLLK*" /label="ykrA CDS" gene 1412362..1413135 /gene="ykrA" /locus_tag="BSU_14550" /old_locus_tag="BSU14550" /label="ykrA gene" downshifts 1413106 /Source="Nicolas_upshifts" /id="D814" /incds=0 /nref=184 /ntot=249 /MaxReadThrough="2.83896" /MaxDrop="6.20802" /score="28.5519453" /energy="-15.4" /TU="U1201" /idTUdmin="U1201" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1413171..1413725) /gene="defB" /locus_tag="BSU_14560" /old_locus_tag="BSU14560" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11429456, 16207374, 23944997, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11429456, 16207374, 23944997, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-formyl-cysteine deformylase (promiscuous)" /protein_id="NP_389339.1" /db_xref="EnsemblGenomes-Gn:BSU14560" /db_xref="EnsemblGenomes-Tr:CAB13329" /db_xref="GOA:Q45495" /db_xref="InterPro:IPR023635" /db_xref="InterPro:IPR036821" /db_xref="SubtiList:BG11815" /db_xref="UniProtKB/Swiss-Prot:Q45495" /translation="MITMENIVRDGHPALRETAEPVELPPTDAEKQQLADMIEFVKNS QNPELAEKYKLRPGVGLAAPQINIKKRMIAVHAEDASGKLYSYALFNPKIVSHSVEKS YLTSGEGCLSVDEAIPGYVPRYARIRVKGTTLEGENIDIRLKGFPAIVFQHEIDHLNG VMFYDHIDKENPFKEPENAIAIER*" /label="defB CDS" gene complement(1413171..1413725) /gene="defB" /locus_tag="BSU_14560" /old_locus_tag="BSU14560" /label="defB gene" downshifts complement(1413182) /Source="Nicolas_upshifts" /id="D815" /incds=0 /nref=208 /ntot=265 /MaxReadThrough="1.87469" /MaxDrop="5.89844" /score="28.3817715" /energy="-15.4" /TU="NA" /idTUdmin="U1202" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1413747..1413766) /Source="Nicolas_upshift_promotors" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1413757) /Source="Nicolas_upshifts" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1413781..1413788) /Source="Nicolas_upshift_promotors" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1413810 /Source="Nicolas_upshifts" /id="D816" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="0.95601" /MaxDrop="4.18336" /score="0.455865843" /energy="-17.1" /TU="NA" /idTUdmin="U1201" /TUdmin=682 /isTUend="FALSE" /label="downshifts" downshifts complement(1413834) /Source="Nicolas_upshifts" /id="D817" /incds=0 /nref=44 /ntot=63 /MaxReadThrough="2.11854" /MaxDrop="8.20445" /score="-8.94821426" /energy="-15.3" /TU="NA" /idTUdmin="U1204" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(1413835..1413993) /gene="ykzV" /locus_tag="BSU_14569" /old_locus_tag="BSU14569" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative type I toxin (toxin I motif)" /protein_id="YP_003097725.1" /db_xref="EnsemblGenomes-Gn:BSU14569" /db_xref="EnsemblGenomes-Tr:CAX52616" /db_xref="GOA:C0H409" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H409" /translation="MYGYGYGGGCCSYGGYGYGGCGYGYGRTFALIVVLFILLIIVGA AYLGGGCC*" /label="ykzV CDS" gene complement(1413835..1413993) /gene="ykzV" /locus_tag="BSU_14569" /old_locus_tag="BSU14569" /label="ykzV gene" CDS complement(1413900..1414043) /locus_tag="BSU_14568" /old_locus_tag="BSU14568" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative antitoxin" /protein_id="YP_009513955.1" /db_xref="EnsemblGenomes-Gn:BSU14568" /db_xref="EnsemblGenomes-Tr:CCQ48596" /db_xref="UniProtKB/TrEMBL:L8E9Z2" /translation="MPTYKGSGVIKRGGYVICMDMVTAEAAAVMVVTDMVAADMATAA PLR*" /label="putative antitoxin CDS" gene complement(1413900..1414043) /locus_tag="BSU_14568" /old_locus_tag="BSU14568" /label="gene" promotor_-35 1413989..1413993 /Source="Nicolas_upshift_promotors" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1413994..1414062) /Source="Nicolas_S_feature" /locus_tag="new_1527018_1527086_c" /HighExp="S8, S7, BT, S6, G/S, B36, Pyr, S5, B60, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S530" promotor_-10 1414003..1414017 /Source="Nicolas_upshift_promotors" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1414030 /Source="Nicolas_upshifts" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1414046..1414065) /Source="Nicolas_upshift_promotors" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1414075) /Source="Nicolas_upshifts" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1414078..1414087) /Source="Nicolas_upshift_promotors" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1414149..1414156 /Source="Nicolas_upshift_promotors" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1414170..1414189 /Source="Nicolas_upshift_promotors" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1414174 /Source="Nicolas_upshifts" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="upshifts" CDS 1414207..1414878 /gene="ykyA" /locus_tag="BSU_14570" /old_locus_tag="BSU14570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16684363, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389340.2" /db_xref="EnsemblGenomes-Gn:BSU14570" /db_xref="EnsemblGenomes-Tr:CAB13330" /db_xref="GOA:P21884" /db_xref="InterPro:IPR019454" /db_xref="InterPro:IPR036785" /db_xref="SubtiList:BG10206" /db_xref="UniProtKB/Swiss-Prot:P21884" /translation="MKDAIKRRPGIKIGAFCAMALILTGCMGQDPVDSLHHSLEKAAE SEKPFQEEQNTLKELEAKENQLYDSVMKLNMDDYKKIVALSNKALENVSKREEHLKLE NDSMKKSETEFEEAKTSAEHIKEKDIKEKADAAANHMEKRYTSYGTMYKEYKKALELN KKLYMQLKDKDLTRDDLDQQIDKVNASYEKILKYSGEFNEQTEKYNKAREDLYDAAGY RVKKS*" /label="ykyA CDS" gene 1414207..1414878 /gene="ykyA" /locus_tag="BSU_14570" /old_locus_tag="BSU14570" /label="ykyA gene" promotor_-35 1414546..1414555 /Source="Nicolas_upshift_promotors" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1414568..1414586 /Source="Nicolas_upshift_promotors" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1414580 /Source="Nicolas_upshifts" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1414825 /Source="Nicolas_upshifts" /id="D818" /incds=0 /nref=96 /ntot=244 /MaxReadThrough="3.9299" /MaxDrop="6.03956" /score="20.6110953" /energy="-9.9" /TU="U1205" /idTUdmin="U1206" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-35 1415053..1415058 /Source="Nicolas_upshift_promotors" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1415075..1415094 /Source="Nicolas_upshift_promotors" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1415076..1415301 /Source="Nicolas_S_feature" /locus_tag="new_1528100_1528325" /HighExp="nit, MG-0.1, Diami, MG-0.2, ferm, dia5, Lbexp, dia0, Paraq, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S531" upshifts 1415076 /Source="Nicolas_upshifts" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1415080..1415099) /Source="Nicolas_upshift_promotors" /id="U1208" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.363636363636364" /psig="0.616383616383616" /xcortree=293 /SigmaFactorBS="tagttacactctgctttgaactgtattatttcgaagttgtaa aaaactaatacaacaCCGCTTAACATGGATTAGTTtacaccaaataaagaagaaccgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1415096) /Source="Nicolas_upshifts" /id="U1208" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.363636363636364" /psig="0.616383616383616" /xcortree=293 /SigmaFactorBS="tagttacactctgctttgaactgtattatttcgaagttgtaa aaaactaatacaacaCCGCTTAACATGGATTAGTTtacaccaaataaagaagaaccgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1415200..1415208) /Source="Nicolas_upshift_promotors" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1415206) /Source="Nicolas_upshifts" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1415222..1415230) /Source="Nicolas_upshift_promotors" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1415302..1416417 /gene="pdhA" /locus_tag="BSU_14580" /old_locus_tag="BSU14580" /EC_number="1.2.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1729239, 1784816, 4984174, 6409095, 6815422, 9352926, 9588797, 11976308, 12469342" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729239, 1784816, 4984174, 6409095, 6815422, 9352926, 9588797, 11976308, 12469342; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (E1 alpha subunit)" /protein_id="NP_389341.1" /db_xref="EnsemblGenomes-Gn:BSU14580" /db_xref="EnsemblGenomes-Tr:CAB13331" /db_xref="GOA:P21881" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR017596" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10207" /db_xref="UniProtKB/Swiss-Prot:P21881" /translation="MAAKTKKAIVDSKKQFDAIKKQFETFQILNEKGEVVNEAAMPDL TDDQLKELMRRMVFTRVLDQRSISLNRQGRLGFYAPTAGQEASQIATHFALEKEDFVL PGYRDVPQLIWHGLPLYQAFLFSRGHFRGNQMPDDVNALSPQIIIGAQYIQTAGVALG LKKRGKKAVAITYTGDGGASQGDFYEGINFAGAYKAPAIFVVQNNRYAISTPVEKQSA AETIAQKAVAAGIVGVQVDGMDPLAVYAATAEARERAINGEGPTLIETLTFRYGPHTM AGDDPTKYRTKEIENEWEQKDPLVRFRAFLENKGLWSEEEEAKVIEDAKEEIKQAIKK ADAEPKQKVTDLMKIMYEKMPHNLEEQFEIYTQKESK*" /label="pdhA CDS" gene 1415302..1416417 /gene="pdhA" /locus_tag="BSU_14580" /old_locus_tag="BSU14580" /label="pdhA gene" CDS 1416421..1417398 /gene="pdhB" /locus_tag="BSU_14590" /old_locus_tag="BSU14590" /EC_number="1.2.4.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 9352926, 9588797, 9891797, 10735853, 11976308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 9352926, 9588797, 9891797, 10735853, 11976308; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (E1 beta subunit)" /protein_id="NP_389342.1" /db_xref="EnsemblGenomes-Gn:BSU14590" /db_xref="EnsemblGenomes-Tr:CAB13332" /db_xref="GOA:P21882" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG10208" /db_xref="UniProtKB/Swiss-Prot:P21882" /translation="MAQMTMIQAITDALRTELKNDENVLVFGEDVGVNGGVFRATEGL QKEFGEDRVFDTPLAESGIGGLALGLGLNGFRPVMEIQFFGFVYEVMDSVSGQMARMR YRSGGRWTSPVTIRSPFGGGVHTPELHADSLEGLVAQQPGIKVVIPSTPYDAKGLLIS AIRDNDPVVFLEHMKLYRSFRQEVPEEEYTIELGKADVKREGTDLSIITYGAMVHESL KAADELEKDGISAEVVDLRTVSPLDIDTIIASVEKTGRAIVVQEAQKQAGIAANVVAE INDRAILSLEAPVLRVAAPDTVFPFSQAESVWLPNHKDVLETARKVLEF*" /label="pdhB CDS" gene 1416421..1417398 /gene="pdhB" /locus_tag="BSU_14590" /old_locus_tag="BSU14590" /label="pdhB gene" S_feature 1417399..1417512 /Source="Nicolas_S_feature" /locus_tag="new_1530423_1530536" /HighExp="G150, LBGexp, MG-0.1, G180, C30, Diami, Oxctl, G135, ferm, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S532" promotor_-10 complement(1417433..1417452) /Source="Nicolas_upshift_promotors" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1417450) /Source="Nicolas_upshifts" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1417467..1417470) /Source="Nicolas_upshift_promotors" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1417513..1418841 /gene="pdhC" /locus_tag="BSU_14600" /old_locus_tag="BSU14600" /EC_number="2.3.1.12" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 9352926, 9588797, 10735853, 11976308, 22720735, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 9352926, 9588797, 10735853, 11976308, 22720735, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (dihydrolipoamide acetyltransferase E2 subunit)" /protein_id="NP_389343.1" /db_xref="EnsemblGenomes-Gn:BSU14600" /db_xref="EnsemblGenomes-Tr:CAB13333" /db_xref="GOA:P21883" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10209" /db_xref="UniProtKB/Swiss-Prot:P21883" /translation="MAFEFKLPDIGEGIHEGEIVKWFVKPNDEVDEDDVLAEVQNDKA VVEIPSPVKGKVLELKVEEGTVATVGQTIITFDAPGYEDLQFKGSDESDDAKTEAQVQ STAEAGQDVAKEEQAQEPAKATGAGQQDQAEVDPNKRVIAMPSVRKYAREKGVDIRKV TGSGNNGRVVKEDIDSFVNGGAQEAAPQETAAPQETAAKPAAAPAPEGEFPETREKMS GIRKAIAKAMVNSKHTAPHVTLMDEVDVTNLVAHRKQFKQVAADQGIKLTYLPYVVKA LTSALKKFPVLNTSIDDKTDEVIQKHYFNIGIAADTEKGLLVPVVKNADRKSVFEISD EINGLATKAREGKLAPAEMKGASCTITNIGSAGGQWFTPVINHPEVAILGIGRIAEKA IVRDGEIVAAPVLALSLSFDHRMIDGATAQNALNHIKRLLNDPQLILMEA*" /label="pdhC CDS" gene 1417513..1418841 /gene="pdhC" /locus_tag="BSU_14600" /old_locus_tag="BSU14600" /label="pdhC gene" promotor_-35 1417657..1417664 /Source="Nicolas_upshift_promotors" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1417679..1417698 /Source="Nicolas_upshift_promotors" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1417682 /Source="Nicolas_upshifts" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="upshifts" CDS 1418846..1420258 /gene="pdhD" /locus_tag="BSU_14610" /old_locus_tag="BSU14610" /EC_number="1.8.1.4" /EC_number="1.2.1.25" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 6815422, 9352926, 9588797, 12682299, 21856851" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 6815422, 9352926, 9588797, 12682299, 21856851; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="dihydrolipoamide dehydrogenase E3 subunit of both pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase complexes" /protein_id="NP_389344.1" /db_xref="EnsemblGenomes-Gn:BSU14610" /db_xref="EnsemblGenomes-Tr:CAB13334" /db_xref="GOA:P21880" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10210" /db_xref="UniProtKB/Swiss-Prot:P21880" /translation="MVVGDFPIETDTLVIGAGPGGYVAAIRAAQLGQKVTVVEKATLG GVCLNVGCIPSKALINAGHRYENAKHSDDMGITAENVTVDFTKVQEWKASVVNKLTGG VAGLLKGNKVDVVKGEAYFVDSNSVRVMDENSAQTYTFKNAIIATGSRPIELPNFKYS ERVLNSTGALALKEIPKKLVVIGGGYIGTELGTAYANFGTELVILEGGDEILPGFEKQ MSSLVTRRLKKKGNVEIHTNAMAKGVEERPDGVTVTFEVKGEEKTVDADYVLITVGRR PNTDELGLEQVGIEMTDRGIVKTDKQCRTNVPNIYAIGDIIEGPPLAHKASYEGKIAA EAIAGEPAEIDYLGIPAVVFSEPELASVGYTEAQAKEEGLDIVAAKFPFAANGRALSL NETDGFMKLITRKEDGLVIGAQIAGASASDMISELSLAIEGGMTAEDIAMTIHAHPTL GEITMEAAEVAIGSPIHIVK*" /label="pdhD CDS" gene 1418846..1420258 /gene="pdhD" /locus_tag="BSU_14610" /old_locus_tag="BSU14610" /label="pdhD gene" downshifts 1420255 /Source="Nicolas_upshifts" /id="D819" /incds=0 /nref=241 /ntot=268 /MaxReadThrough="1.82289" /MaxDrop="9.27853" /score="33.2247807" /energy="-12.1" /TU="NA" /idTUdmin="U1207" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1420303..1420677) /gene="slp" /locus_tag="BSU_14620" /old_locus_tag="BSU14620" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1936936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1936936; Product type s : structure" /codon_start=1 /transl_table=11 /product="small peptidoglycan-associated lipoprotein" /protein_id="NP_389345.1" /db_xref="EnsemblGenomes-Gn:BSU14620" /db_xref="EnsemblGenomes-Tr:CAB13335" /db_xref="GOA:P39910" /db_xref="SubtiList:BG10211" /db_xref="UniProtKB/Swiss-Prot:P39910" /translation="MRYRAVFPMLIIVFALSGCTLSTINPMKKSRIDNIHHTQILFFS DENQIDQEAPYYDALLDLEKDYPEQIDKMKVYDKKEGWEDEIETVPTLMVVDQRHVVV KIEGCVKKKEDIIKPLQHVLSK*" /label="slp CDS" gene complement(1420303..1420677) /gene="slp" /locus_tag="BSU_14620" /old_locus_tag="BSU14620" /label="slp gene" downshifts complement(1420351) /Source="Nicolas_upshifts" /id="D820" /incds=0 /nref=26 /ntot=132 /MaxReadThrough="1.54024" /MaxDrop="3.69756" /score="4.23955997" /energy="-12.1" /TU="NA" /idTUdmin="U1212" /TUdmin=3 /isTUend="TRUE" /label="downshifts" misc_feature complement(1420708..1420727) /Source="Nicolas_upshift_promotors" /id="U1212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=581 /SigmaFactorBS="ggtttcaattatataacaattaggtaacaagaagcagattaa gccgtctctCGTGATAAACTAAAGCTAGTtaactactgtttatacagaggagaagata g" /listShort="slp" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1420718) /Source="Nicolas_upshifts" /id="U1212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=581 /SigmaFactorBS="ggtttcaattatataacaattaggtaacaagaagcagattaa gccgtctctCGTGATAAACTAAAGCTAGTtaactactgtttatacagaggagaagata g" /listShort="slp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1420881..1420886 /Source="Nicolas_upshift_promotors" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="promotor_-35" promotor_-10 1420902..1420920 /Source="Nicolas_upshift_promotors" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="promotor_-10" upshifts 1420912 /Source="Nicolas_upshifts" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="upshifts" S_feature 1420916..1421025 /Source="Nicolas_S_feature" /locus_tag="new_1533940_1534049" /HighExp="S4, S5, S7, S6, S8, S3, BT, G/S, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S533" downshifts complement(1420948) /Source="Nicolas_upshifts" /id="D821" /incds=0 /nref=4 /ntot=18 /MaxReadThrough="1.96608" /MaxDrop="3.4036" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin=308 /isTUend="FALSE" /label="downshifts" promotor_-35 1421009..1421016 /Source="Nicolas_upshift_promotors" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1421027 /Source="Nicolas_upshifts" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1421031..1421050 /Source="Nicolas_upshift_promotors" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 1421046..1421256 /gene="srrA" /locus_tag="BSU_misc_RNA_70" /product="small regulatory RNA and messenger RNA (argininemetabolism)" /experiment="publication(s) with functional evidences, PMID:16164558, 17011578, 17020585, 17576690, 18511073, 18586936, 19726675, 20444087, 27449348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164558, 17011578, 17020585, 17576690, 18511073, 18586936, 19726675, 20444087, 27449348; Product type n: RNA" /function="16.3: Control" /label="srrA RNA" gene 1421046..1421256 /gene="srrA" /locus_tag="BSU_misc_RNA_70" /label="srrA gene" CDS 1421096..1421215 /gene="rgpA" /locus_tag="BSU_14629" /old_locus_tag="BSU14629" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16164558, 20444087, 27449348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164558, 20444087, 27449348; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of GapA synthesis" /protein_id="YP_003097726.1" /db_xref="EnsemblGenomes-Gn:BSU14629" /db_xref="EnsemblGenomes-Tr:CAX52617" /db_xref="InterPro:IPR025236" /db_xref="UniProtKB/Swiss-Prot:C0H410" /translation="MGTIVCQDCNEAIHYFEDEKVTTLYGTCCGQCQCPVDEE*" /label="rgpA CDS" gene 1421096..1421215 /gene="rgpA" /locus_tag="BSU_14629" /old_locus_tag="BSU14629" /label="rgpA gene" downshifts complement(1421102) /Source="Nicolas_upshifts" /id="D822" /incds=0 /nref=6 /ntot=35 /MaxReadThrough="3.43398" /MaxDrop="4.36472" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin=154 /isTUend="FALSE" /label="downshifts" downshifts 1421202 /Source="Nicolas_upshifts" /id="D823" /incds=0 /nref=59 /ntot=171 /MaxReadThrough="5.69396" /MaxDrop="7.24152" /score="51.2534618" /energy="-16.8" /TU="U1214" /idTUdmin="U1213" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1421247..1422850 /Source="Nicolas_S_feature" /locus_tag="new_1534271_1535874" /HighExp="M9-stat, M0t90, B60, M40t90, T1.30H, T2.0H, T2.30H, T3.30H, T3.0H, T0.30H" /AntisenseName="speA" /AntisenseCor="-0.33575411980382203" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.998" /label="S534" CDS complement(1421255..1422727) /gene="speA" /locus_tag="BSU_14630" /old_locus_tag="BSU14630" /EC_number="4.1.1.19" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9723923, 19114526, 19255484, 20876533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 19114526, 19255484, 20876533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine decarboxylase" /protein_id="NP_389346.1" /db_xref="EnsemblGenomes-Gn:BSU14630" /db_xref="EnsemblGenomes-Tr:CAB13336" /db_xref="GOA:P21885" /db_xref="InterPro:IPR000310" /db_xref="InterPro:IPR008286" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036633" /db_xref="SubtiList:BG10212" /db_xref="UniProtKB/Swiss-Prot:P21885" /translation="MSQHETPLYTGLKKHASRQPVQFHIPGHKKGAGMDPEFRQFIGE NALSIDLINIEPLDDLHAPKGIIKQAQDLAAEAFGADHTFFSVQGTSGAIMTMVMAVC GPGDKIIIPRNVHKSIMTAIVFSGAVPIFIHPEIDNELGISHGITLESAKRALTEHPD AKGLLVINPTYFGVAADLKSIVELAHSFDVPVLVDEAHGVHIHFHDELPLSAMQAGAD IAATSVHKLGGSLTQSSILNMREGLVSKDRVQSILSMLTTTSTSYLLLASLDVARKRL ATEGRQLAEETLKLANQTRDRLNQIEGIYCVGSEILGSKAAYSYDPTKLIISVKSLGL TGHDVEKWLRESFNIEVELSDLYNILCIFTPGDSQNDADRLVEALTEIAQQMSEQDVT HQQTEVLLPEIPLLAMTPRDAFYANTEVIPLKEASGRIIAEFVMVYPPGIPIFIPGEI ITEENISYIFKNLDAGLPVQGPEDSTLHMIRVIKEQKAIQ*" /label="speA CDS" gene complement(1421255..1422727) /gene="speA" /locus_tag="BSU_14630" /old_locus_tag="BSU14630" /label="speA gene" downshifts complement(1421273) /Source="Nicolas_upshifts" /id="D824" /incds=0 /nref=62 /ntot=198 /MaxReadThrough="3.88498" /MaxDrop="6.76978" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" S_feature complement(1422728..1422823) /Source="Nicolas_S_feature" /locus_tag="new_1535752_1535847_c" /HighExp="Paraq, G180, LBGexp, Oxctl, G150, G135, C30, H2O2, BMM, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S535" promotor_-10 complement(1422806..1422825) /Source="Nicolas_upshift_promotors" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1422823) /Source="Nicolas_upshifts" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1422830..1422833 /Source="Nicolas_upshift_promotors" /id="U1216" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2377 /SigmaFactorBS="cgttttttagacgtaaaacaaatgaattatattatgaaCTTG aaagaatgtaaagaACAATTTATGATCAAATGAAgatgctttctcttaagggaagtaa a" /listShort="yktA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1422840..1422847) /Source="Nicolas_upshift_promotors" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1422848..1422867 /Source="Nicolas_upshift_promotors" /id="U1216" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2377 /SigmaFactorBS="cgttttttagacgtaaaacaaatgaattatattatgaaCTTG aaagaatgtaaagaACAATTTATGATCAAATGAAgatgctttctcttaagggaagtaa a" /listShort="yktA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1422852 /Source="Nicolas_upshifts" /id="U1216" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2377 /SigmaFactorBS="cgttttttagacgtaaaacaaatgaattatattatgaaCTTG aaagaatgtaaagaACAATTTATGATCAAATGAAgatgctttctcttaagggaagtaa a" /listShort="yktA" /GFF_Attribute="listLong" /label="upshifts" CDS 1422912..1423178 /gene="yktA" /locus_tag="BSU_14640" /old_locus_tag="BSU14640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19429628, 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389347.1" /db_xref="EnsemblGenomes-Gn:BSU14640" /db_xref="EnsemblGenomes-Tr:CAB13337" /db_xref="InterPro:IPR007920" /db_xref="InterPro:IPR023324" /db_xref="SubtiList:BG11816" /db_xref="UniProtKB/Swiss-Prot:Q45497" /translation="MEYQYPMNEDWTTEEAVDVIAFFQQVELAYEKGADREELLKAYR RFKEIVPGKAEEKKLCGEFEEQSTYSPYRTVKQARESDHAKIKM*" /label="yktA CDS" gene 1422912..1423178 /gene="yktA" /locus_tag="BSU_14640" /old_locus_tag="BSU14640" /label="yktA gene" downshifts 1423160 /Source="Nicolas_upshifts" /id="D825" /incds=0 /nref=105 /ntot=250 /MaxReadThrough="2.62284" /MaxDrop="5.09814" /score="40.0811023" /energy="-16.1" /TU="NA" /idTUdmin="U1214" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1423211..1423849) /gene="yktB" /locus_tag="BSU_14650" /old_locus_tag="BSU14650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25643072" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389348.1" /db_xref="EnsemblGenomes-Gn:BSU14650" /db_xref="EnsemblGenomes-Tr:CAB13338" /db_xref="InterPro:IPR009403" /db_xref="PDB:2A8E" /db_xref="SubtiList:BG11817" /db_xref="UniProtKB/Swiss-Prot:Q45498" /translation="MTQMRFTEEDFNTFTIEGLDARMEVLKETVRPKLTALGEHFAPT LSALTGDEMFPHVAKHARRSVNPPADSWVAFANSKRGYKKLPHFQIGLWESHVFVWFA IIYESPIKEEYGKLLEVNQETITKNIPDSFVWSADHTKPGVHKQSEMDKEQLKTLFER LQTVKKAELLCGIQLQKEEVLNMNNQEFLQRIDDAFKQLAFLYRLTQKVTQA*" /label="yktB CDS" gene complement(1423211..1423849) /gene="yktB" /locus_tag="BSU_14650" /old_locus_tag="BSU14650" /label="yktB gene" downshifts complement(1423236) /Source="Nicolas_upshifts" /id="D826" /incds=0 /nref=184 /ntot=257 /MaxReadThrough="2.62959" /MaxDrop="6.54203" /score="26.7765804" /energy="-14.5" /TU="U1217" /idTUdmin="U1217" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1423870..1423889) /Source="Nicolas_upshift_promotors" /id="U1217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.997002997002997" /xcortree=2002 /SigmaFactorBS="actcgtttattaccacatttctccttacttcaaacgcgctca atctTTTTGaagctcgtatgaacTGTGATAAAATATGTATACTtagcatgaaggagga a" /listShort="yktB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1423894) /Source="Nicolas_upshifts" /id="U1217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.997002997002997" /xcortree=2002 /SigmaFactorBS="actcgtttattaccacatttctccttacttcaaacgcgctca atctTTTTGaagctcgtatgaacTGTGATAAAATATGTATACTtagcatgaaggagga a" /listShort="yktB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1423904..1423908) /Source="Nicolas_upshift_promotors" /id="U1217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.997002997002997" /xcortree=2002 /SigmaFactorBS="actcgtttattaccacatttctccttacttcaaacgcgctca atctTTTTGaagctcgtatgaacTGTGATAAAATATGTATACTtagcatgaaggagga a" /listShort="yktB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1423919..1423925 /Source="Nicolas_upshift_promotors" /id="U1218" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=209 /SigmaFactorBS="tttatcacagttcatacgagcttcaaaaagattgagcgCGTT TGAagtaaggagaaatgTGGTAATAAACGAGTAGGTaaacacacaattttcagaatca t" /listShort="S536, ykzI, suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1423940..1423958 /Source="Nicolas_upshift_promotors" /id="U1218" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=209 /SigmaFactorBS="tttatcacagttcatacgagcttcaaaaagattgagcgCGTT TGAagtaaggagaaatgTGGTAATAAACGAGTAGGTaaacacacaattttcagaatca t" /listShort="S536, ykzI, suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1423941 /Source="Nicolas_upshifts" /id="U1218" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=209 /SigmaFactorBS="tttatcacagttcatacgagcttcaaaaagattgagcgCGTT TGAagtaaggagaaatgTGGTAATAAACGAGTAGGTaaacacacaattttcagaatca t" /listShort="S536, ykzI, suhB, ykzC, S537" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1423979..1423988 /Source="Nicolas_upshift_promotors" /id="U1219" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1258 /SigmaFactorBS="ataaacgagtaggtaaacacacaattttcagaatCATGTTGC GCgtaaatagaacaATCATACGATATAAGAAGTAatcattgttgaatggcaaaatggg a" /listShort="S536, ykzI, suhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1424001..1424020 /Source="Nicolas_upshift_promotors" /id="U1219" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1258 /SigmaFactorBS="ataaacgagtaggtaaacacacaattttcagaatCATGTTGC GCgtaaatagaacaATCATACGATATAAGAAGTAatcattgttgaatggcaaaatggg a" /listShort="S536, ykzI, suhB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1424005..1424088 /Source="Nicolas_S_feature" /locus_tag="new_1537029_1537112" /HighExp="Etha, S7, M9-stat, S6, S8, BT, Gly, Salt, B60, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB" /TUshortPSig="0.987, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S536" upshifts 1424005 /Source="Nicolas_upshifts" /id="U1219" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1258 /SigmaFactorBS="ataaacgagtaggtaaacacacaattttcagaatCATGTTGC GCgtaaatagaacaATCATACGATATAAGAAGTAatcattgttgaatggcaaaatggg a" /listShort="S536, ykzI, suhB" /GFF_Attribute="listLong" /label="upshifts" CDS 1424089..1424277 /gene="ykzI" /locus_tag="BSU_14660" /old_locus_tag="BSU14660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved general stress protein" /protein_id="NP_389349.1" /db_xref="EnsemblGenomes-Gn:BSU14660" /db_xref="EnsemblGenomes-Tr:CAB13339" /db_xref="SubtiList:BG13337" /db_xref="UniProtKB/Swiss-Prot:O31719" /translation="MRQVVKEGFKEEKNNRVAVWRLEVDYELATLYEAMQKENEEQIE QSKNKLERLRKEWIRLNG*" /label="ykzI CDS" gene 1424089..1424277 /gene="ykzI" /locus_tag="BSU_14660" /old_locus_tag="BSU14660" /label="ykzI gene" downshifts complement(1424094) /Source="Nicolas_upshifts" /id="D827" /incds=0 /nref=1 /ntot=15 /MaxReadThrough="1.50398" /MaxDrop="3.97385" /score="26.7765804" /energy="-14.5" /TU="NA" /idTUdmin="U1220" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1424270 /Source="Nicolas_upshifts" /id="D828" /incds=0 /nref=13 /ntot=45 /MaxReadThrough="7.33866" /MaxDrop="6.12123" /score="-8.73613673" /energy="-8.1" /TU="U1218,U1219" /idTUdmin="U1219" /TUdmin="-628" /isTUend="FALSE" /label="downshifts" upshifts complement(1424292) /Source="Nicolas_upshifts" /id="U1220" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.616383616383616" /psig="0.105894105894106" /xcortree=118 /SigmaFactorBS="agcaaggaaaatgaaaaatatcccttctcacgtaaaaacgaa ccattcaTGCGgttcgttttcactatcgcttttttacccgttaagacgaatccattct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1424300..1424303) /Source="Nicolas_upshift_promotors" /id="U1220" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.616383616383616" /psig="0.105894105894106" /xcortree=118 /SigmaFactorBS="agcaaggaaaatgaaaaatatcccttctcacgtaaaaacgaa ccattcaTGCGgttcgttttcactatcgcttttttacccgttaagacgaatccattct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1424347..1424350 /Source="Nicolas_upshift_promotors" /id="U1221" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig=1 /xcortree=1962 /SigmaFactorBS="gttcgtttttacgtgagaagggatatttttcattttcCTTGc tttttcattgccgttATCAGTATCCTATAAAATAAaaggtctacatagaagagaggta c" /listShort="suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1424367..1424386 /Source="Nicolas_upshift_promotors" /id="U1221" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig=1 /xcortree=1962 /SigmaFactorBS="gttcgtttttacgtgagaagggatatttttcattttcCTTGc tttttcattgccgttATCAGTATCCTATAAAATAAaaggtctacatagaagagaggta c" /listShort="suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1424370 /Source="Nicolas_upshifts" /id="U1221" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig=1 /xcortree=1962 /SigmaFactorBS="gttcgtttttacgtgagaagggatatttttcattttcCTTGc tttttcattgccgttATCAGTATCCTATAAAATAAaaggtctacatagaagagaggta c" /listShort="suhB, ykzC, S537" /GFF_Attribute="listLong" /label="upshifts" CDS 1424417..1425214 /gene="suhB" /locus_tag="BSU_14670" /old_locus_tag="BSU14670" /EC_number="3.1.3.-" /EC_number="3.1.3.25" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11914086, 16682444, 22333191, 27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914086, 16682444, 22333191, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inositol monophosphatase / 5' nucleotidase (purine nucleoside monophosphate)" /protein_id="NP_389350.1" /db_xref="EnsemblGenomes-Gn:BSU14670" /db_xref="EnsemblGenomes-Tr:CAB13340" /db_xref="GOA:Q45499" /db_xref="InterPro:IPR000760" /db_xref="InterPro:IPR020550" /db_xref="InterPro:IPR020583" /db_xref="InterPro:IPR033942" /db_xref="SubtiList:BG11818" /db_xref="UniProtKB/Swiss-Prot:Q45499" /translation="MTNWTEIDEIAKKWIREAGARITQSMHESLTIETKSNPNDLVTN IDKETEKFFIDRIQETFPGHRILGEEGQGDKIHSLEGVVWIIDPIDGTMNFVHQQRNF AISIGIFENGEGKIGLIYDVVHDELYHAFSGRGAYMNETKLAPLKETVIEEAILAINA TWVTENRRIDQSVLAPLVKRVRGTRSYGSAALELANVAAGRIDAYITMRLAPWDYAAG CVLLNEVGGTYTTIEGEPFTFLENHSVLAGNPSIHKTIFEEYLHARK*" /label="suhB CDS" gene 1424417..1425214 /gene="suhB" /locus_tag="BSU_14670" /old_locus_tag="BSU14670" /label="suhB gene" CDS 1425240..1425668 /gene="ykzC" /locus_tag="BSU_14680" /old_locus_tag="BSU14680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544224; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_389351.1" /db_xref="EnsemblGenomes-Gn:BSU14680" /db_xref="EnsemblGenomes-Tr:CAB13341" /db_xref="GOA:O31720" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13331" /db_xref="UniProtKB/Swiss-Prot:O31720" /translation="MLEKLAEAHPVWKEEEFGDKDAEDYIISYSMYNGSWLVWEKDGM PVAVSYHLEWSPSNGKPWLGTVLIDPAEEKKGHAKMIIEQISKLLRAKHKAMFAGVPI ERREWILFLSQCGFEQLKTEKDEKGKSFMILVKPLAEAAV*" /label="ykzC CDS" gene 1425240..1425668 /gene="ykzC" /locus_tag="BSU_14680" /old_locus_tag="BSU14680" /label="ykzC gene" downshifts 1425625 /Source="Nicolas_upshifts" /id="D829" /incds=0 /nref=80 /ntot=232 /MaxReadThrough="4.50069" /MaxDrop="4.3098" /score="-9.99315734" /energy="-11.8" /TU="U1218,U1221" /idTUdmin="U1218" /TUdmin="-153" /isTUend="FALSE" /label="downshifts" S_feature 1425669..1426622 /Source="Nicolas_S_feature" /locus_tag="new_1538693_1539646" /HighExp="H2O2, dia15, Diami, Paraq, G180, G135, G150, dia5, Heat, LBGexp" /AntisenseName="yktD" /AntisenseCor="-1.5120906229522399E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="0.117724" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S537" downshifts complement(1425744) /Source="Nicolas_upshifts" /id="D830" /incds=0 /nref=4 /ntot=85 /MaxReadThrough="0.88821" /MaxDrop="3.44773" /score="19.9363134" /energy="-12.8" /TU="NA" /idTUdmin="U1222" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1425746..1426660) /gene="yktD" /locus_tag="BSU_14690" /old_locus_tag="BSU14690" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17928718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative AdoMet-dependent methyltransferase" /protein_id="NP_389352.1" /db_xref="EnsemblGenomes-Gn:BSU14690" /db_xref="EnsemblGenomes-Tr:CAB13342" /db_xref="GOA:Q45500" /db_xref="InterPro:IPR007213" /db_xref="InterPro:IPR011610" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11819" /db_xref="UniProtKB/Swiss-Prot:Q45500" /translation="MRKNESSLTSLISAFARAYHSRYDTPLIFDDFIAKDLINEKEFI DISKNMIQEISFFNKEIAERLQNDPEKILKWVAQIQLSPTPLARASYCEKVLHNELIL GAKQYVILGAGLDTFCFRHPELENSLQVFEVDHPATQQLKKNKLKDANLTIPGHLHFV PMDFTKTFSYDPLLDEGFKNTKTFFSLLGVSYYVTREENASLISNLFSHVPPGSSIVF DYADETLFTAKGTSNRVEHMVKMAAASGEPMKSCFTYQEIEHLLESSGLLIYEHLSPD DINDLFFSNRKDNLSAFETIHYIHAVKK*" /label="yktD CDS" gene complement(1425746..1426660) /gene="yktD" /locus_tag="BSU_14690" /old_locus_tag="BSU14690" /label="yktD gene" promotor_-10 complement(1426726..1426745) /Source="Nicolas_upshift_promotors" /id="U1222" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=584 /SigmaFactorBS="gatcgcgcgtccagttaagagcaaaaaCATTGACAaaaaaat ttatttaTGCTAAAATTTACTATTAATatatttgtatgtataataagattctcctggc c" /listShort="yktD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1426734) /Source="Nicolas_upshifts" /id="U1222" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=584 /SigmaFactorBS="gatcgcgcgtccagttaagagcaaaaaCATTGACAaaaaaat ttatttaTGCTAAAATTTACTATTAATatatttgtatgtataataagattctcctggc c" /listShort="yktD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1426760..1426767) /Source="Nicolas_upshift_promotors" /id="U1222" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=584 /SigmaFactorBS="gatcgcgcgtccagttaagagcaaaaaCATTGACAaaaaaat ttatttaTGCTAAAATTTACTATTAATatatttgtatgtataataagattctcctggc c" /listShort="yktD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1427012..1428577) /gene="nprE" /locus_tag="BSU_14700" /old_locus_tag="BSU14700" /EC_number="3.4.24.28" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2128597, 6090407, 8436952, 15205417, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2128597, 6090407, 8436952, 15205417, 26728191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular neutral metalloprotease" /protein_id="NP_389353.1" /db_xref="EnsemblGenomes-Gn:BSU14700" /db_xref="EnsemblGenomes-Tr:CAB13343" /db_xref="GOA:P68736" /db_xref="InterPro:IPR001570" /db_xref="InterPro:IPR011096" /db_xref="InterPro:IPR013856" /db_xref="InterPro:IPR023612" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG10448" /db_xref="UniProtKB/Swiss-Prot:P68736" /translation="MGLGKKLSVAVAASFMSLSISLPGVQAAEGHQLKENQTNFLSKN AIAQSELSAPNDKAVKQFLKKNSNIFKGDPSKRLKLVESTTDALGYKHFRYAPVVNGV PIKDSQVIVHVDKSDNVYAVNGELHNQSAAKTDNSQKVSSEKALALAFKAIGKSPDAV SNGAAKNSNKAELKAIETKDGSYRLAYDVTIRYVEPEPANWEVLVDAETGSILKQQNK VEHAAATGSGTTLKGATVPLNISYEGGKYVLRDLSKPTGTQIITYDLQNRQSRLPGTL VSSTTKTFTSSSQRAAVDAHYNLGKVYDYFYSNFKRNSYDNKGSKIVSSVHYGTQYNN AAWTGDQMIYGDGDGSFFSPLSGSLDVTAHEMTHGVTQETANLIYENQPGALNESFSD VFGYFNDTEDWDIGEDITVSQPALRSLSNPTKYNQPDNYANYRNLPNTDEGDYGGVHT NSGIPNKAAYNTITKLGVSKSQQIYYRALTTYLTPSSTFKDAKAALIQSARDLYGSTD AAKVEAAWNAVGL*" /label="nprE CDS" gene complement(1427012..1428577) /gene="nprE" /locus_tag="BSU_14700" /old_locus_tag="BSU14700" /label="nprE gene" promotor_-10 complement(1428612..1428631) /Source="Nicolas_upshift_promotors" /id="U1223" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.526473526473527" /psig="0.993006993006993" /xcortree=3157 /SigmaFactorBS="tactatcaattttgtctagttatgttagtttTTGTTGAGtat tccagaatgcTAGTTTAATATAACAATATAaagttttcagtattttcaaaaaggggga t" /listShort="nprE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1428623) /Source="Nicolas_upshifts" /id="U1223" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.526473526473527" /psig="0.993006993006993" /xcortree=3157 /SigmaFactorBS="tactatcaattttgtctagttatgttagtttTTGTTGAGtat tccagaatgcTAGTTTAATATAACAATATAaagttttcagtattttcaaaaaggggga t" /listShort="nprE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1428645..1428652) /Source="Nicolas_upshift_promotors" /id="U1223" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.526473526473527" /psig="0.993006993006993" /xcortree=3157 /SigmaFactorBS="tactatcaattttgtctagttatgttagtttTTGTTGAGtat tccagaatgcTAGTTTAATATAACAATATAaagttttcagtattttcaaaaaggggga t" /listShort="nprE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1428862..1430802 /gene="ylaA" /locus_tag="BSU_14710" /old_locus_tag="BSU14710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16501307" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389354.1" /db_xref="EnsemblGenomes-Gn:BSU14710" /db_xref="EnsemblGenomes-Tr:CAB13344" /db_xref="GOA:O07625" /db_xref="SubtiList:BG13338" /db_xref="UniProtKB/Swiss-Prot:O07625" /translation="MLFVLELFSHYVLHFERYFILSRQSTLLIQWSIVVLAGLYLLVH HPKINRQRTMFLAGVILRIVLLAGVSVELIHQVQSTNFTSAYLREDGKELLPLLHFLL YGYVLLTAFHYMLMPRDHGGKGKFYTFDLAVVSLPIVQMIFSFFSYWKEYPDGMEPIA FVFLFFIITLPIALNVVFFKLYWRTDKILLGLFYTLIIGLLVLLLAPYPNQISKDYGA VMPYTIYLAMAGFLMSYHLFQKSGKVYVRVNKWVTMAVMVFFVLLLNPIYNIGTAAFA VSKPANVHDSFNFVGEHISSEKAEQILKSFFPTDETLYLHDTNMDVHYFYSFESKGYK AEVDEVSQLIRNYEYLQKAHGKKLTNQEYKRKSIAFLERHGRVLHKDHIETKVSQEDG QTVVRIYLKNQLHKKDHADDGAVFYWEKETLMGFSEDPSIYQLDSLLHVHITEQDIHD KVEQMFTALNISKQPYQITDIESDSLLGSMVRVETKVGIVLEFEGESGCLHSLSLPMK KNISMANSRLQHQILSIFDARGSEKKKKSSQGDMVMYTDSSKTYEFVEAQGQLNVYVY SDTPDQSFPYTYRNGTLAYEKVASLYQDVIYKKRMRPIIVQRGDERHYAWLIIIQPFG SNRHDAYVVDGETQEVKSLYES*" /label="ylaA CDS" gene 1428862..1430802 /gene="ylaA" /locus_tag="BSU_14710" /old_locus_tag="BSU14710" /label="ylaA gene" CDS 1430792..1431061 /gene="ylaB" /locus_tag="BSU_14720" /old_locus_tag="BSU14720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 16501307" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389355.1" /db_xref="EnsemblGenomes-Gn:BSU14720" /db_xref="EnsemblGenomes-Tr:CAB13345" /db_xref="GOA:O07626" /db_xref="SubtiList:BG13339" /db_xref="UniProtKB/Swiss-Prot:O07626" /translation="MNHKEKESVFVDLYDLYKEGELEDESMEWMKQHESLFQKNAEDL KSKTCLKRSPGAEEESQIRYMKVYLSSMYICFILLAIWMTVWFYF*" /label="ylaB CDS" gene 1430792..1431061 /gene="ylaB" /locus_tag="BSU_14720" /old_locus_tag="BSU14720" /label="ylaB gene" promotor_-35 1431027..1431031 /Source="Nicolas_upshift_promotors" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1431045..1431064 /Source="Nicolas_upshift_promotors" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1431058 /Source="Nicolas_upshifts" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="upshifts" CDS 1431061..1431582 /gene="sigP" /locus_tag="BSU_14730" /old_locus_tag="BSU14730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16501307, 16728958, 20817771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16501307, 16728958, 20817771; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF-type sigma factor" /protein_id="NP_389356.1" /db_xref="EnsemblGenomes-Gn:BSU14730" /db_xref="EnsemblGenomes-Tr:CAB13346" /db_xref="GOA:O07627" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014296" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13340" /db_xref="UniProtKB/Swiss-Prot:O07627" /translation="MKHRDSIEDLYRQYYQEILNYLFRRTHHLETAKDLAQDTFVKAL NGLASFRGHSSIRTWLYTIAHHTFINWYRRDVKYQFTEISKNEGLTQTTYDQPEQYLS RTVKSETLRQELLKLKDQHQSVLILREFQELSYEEIAEILGWSLSKVNTTLHRARLEL KKNMTKSREEERI*" /label="sigP CDS" gene 1431061..1431582 /gene="sigP" /locus_tag="BSU_14730" /old_locus_tag="BSU14730" /label="sigP gene" CDS 1431579..1431872 /gene="sigQ" /locus_tag="BSU_14740" /old_locus_tag="BSU14740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16501307, 16728958, 20817771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16501307, 16728958, 20817771; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-SigP(YlaC) sigma factor" /protein_id="NP_389357.1" /db_xref="EnsemblGenomes-Gn:BSU14740" /db_xref="EnsemblGenomes-Tr:CAB13347" /db_xref="GOA:O07628" /db_xref="InterPro:IPR027383" /db_xref="SubtiList:BG13341" /db_xref="UniProtKB/Swiss-Prot:O07628" /translation="MTCFLVRDLLPLYLEGDCKRETEHVIEEHLKMCSSCRDMYDTMA EPFELESEQAVEEAYLPEEELRFKQRYYGLLIMKAACWFGAAVAMMLIIKLLI*" /label="sigQ CDS" gene 1431579..1431872 /gene="sigQ" /locus_tag="BSU_14740" /old_locus_tag="BSU14740" /label="sigQ gene" CDS complement(1431912..1432523) /gene="ylaE" /locus_tag="BSU_14750" /old_locus_tag="BSU14750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389358.1" /db_xref="EnsemblGenomes-Gn:BSU14750" /db_xref="EnsemblGenomes-Tr:CAB13348" /db_xref="SubtiList:BG13342" /db_xref="UniProtKB/Swiss-Prot:O07629" /translation="MKKTFVKKAMLTTAAMTSAALLTFGPDAASAKTPVDNTAVQLQH QASTNEDLNTFIDILNQCIYEQDGVYYFDSEKAVELGMTKEEAQVIATLWESTSEFFS IVSQCVYLEDGNYKFDTEKAVELGFTEKEALALEQFFSAVSLKIHILQAAIVLQDDVY SYDKDAALQAGATPLQADVYEKLFSALSQEQLAAIYDMIHPQA*" /label="ylaE CDS" gene complement(1431912..1432523) /gene="ylaE" /locus_tag="BSU_14750" /old_locus_tag="BSU14750" /label="ylaE gene" downshifts complement(1431926) /Source="Nicolas_upshifts" /id="D831" /incds=0 /nref=44 /ntot=184 /MaxReadThrough="1.37453" /MaxDrop="4.23106" /score="20.8244305" /energy="-11.7" /TU="NA" /idTUdmin="U1225" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1432555..1432574) /Source="Nicolas_upshift_promotors" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1432564) /Source="Nicolas_upshifts" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1432589..1432592) /Source="Nicolas_upshift_promotors" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1432779) /Source="Nicolas_upshifts" /id="D832" /incds=0 /nref=18 /ntot=138 /MaxReadThrough="2.72081" /MaxDrop="5.25382" /score="5.78870736" /energy="-8.3" /TU="NA" /idTUdmin="U1226" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" CDS complement(1432796..1432984) /gene="ylaF" /locus_tag="BSU_14760" /old_locus_tag="BSU14760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389359.1" /db_xref="EnsemblGenomes-Gn:BSU14760" /db_xref="EnsemblGenomes-Tr:CAB13349" /db_xref="GOA:O07630" /db_xref="InterPro:IPR035211" /db_xref="SubtiList:BG13343" /db_xref="UniProtKB/Swiss-Prot:O07630" /translation="MKKMNWLLLLFAFAAVFSIMLIGVFIAEKSPAGIIASIVLVCAV MGGGFTLKKKMREQGLLD*" /label="ylaF CDS" gene complement(1432796..1432984) /gene="ylaF" /locus_tag="BSU_14760" /old_locus_tag="BSU14760" /label="ylaF gene" downshifts complement(1432850) /Source="Nicolas_upshifts" /id="D833" /incds=0 /nref=9 /ntot=204 /MaxReadThrough="4.38484" /MaxDrop="3.2214" /score="5.78870736" /energy="-8.3" /TU="U1226" /idTUdmin="U1226" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1433006..1433025) /Source="Nicolas_upshift_promotors" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1433023) /Source="Nicolas_upshifts" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1433038..1433045) /Source="Nicolas_upshift_promotors" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1433051..1433070 /Source="Nicolas_upshift_promotors" /id="U1227" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2497 /SigmaFactorBS="ttttacgtcttatattaagtttacagaaaaacgtgacgcttt taaagaggatgTGTGATATAATATGAAAGTTatctaatttttttaggagatgaaaaag t" /listShort="bipA, ylaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1433058 /Source="Nicolas_upshifts" /id="U1227" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2497 /SigmaFactorBS="ttttacgtcttatattaagtttacagaaaaacgtgacgcttt taaagaggatgTGTGATATAATATGAAAGTTatctaatttttttaggagatgaaaaag t" /listShort="bipA, ylaH" /GFF_Attribute="listLong" /label="upshifts" CDS 1433097..1434935 /gene="bipA" /locus_tag="BSU_14770" /old_locus_tag="BSU14770" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11683274, 12399512, 9642082, 25135187, 26283392; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-associated GTPase" /protein_id="NP_389360.1" /db_xref="EnsemblGenomes-Gn:BSU14770" /db_xref="EnsemblGenomes-Tr:CAB13350" /db_xref="GOA:O07631" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006298" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035651" /db_xref="SubtiList:BG13344" /db_xref="UniProtKB/Swiss-Prot:O07631" /translation="MKLRNDLRNIAIIAHVDHGKTTLVDQLLHQAGTFRANEQVAERA MDSNDLERERGITILAKNTAINYKDTRINILDTPGHADFGGEVERIMKMVDGVVLVVD AYEGCMPQTRFVLKKALEQNLNPVVVVNKIDRDFARPEEVIDEVLDLFIELDANEEQL EFPVVYASAINGTASLDPKQQDENMEALYETIIKHVPAPVDNAEEPLQFQVALLDYND YVGRIGIGRVFRGTMKVGQQVSLMKLDGTAKSFRVTKIFGFQGLKRVEIEEAKAGDLV AVSGMEDINVGETVCPVDHQDPLPVLRIDEPTLQMTFVVNNSPFAGREGKYVTARKIE ERLQSQLQTDVSLRVEPTASPDAWVVSGRGELHLSILIENMRREGYELQVSKPEVIIK EIDGVRCEPVERVQIDVPEEHTGSVMESMGARKGEMVDMINNGNGQVRLIFTVPSRGL IGYSTEFLSLTRGFGILNHTFDSYQPMQAGQVGGRRQGVLVSMENGKATSYGIQGIED RGVIFVEPGTEVYEGMIVGEHNRDNDLVVNVSKMKQQTNVRSATKDQTTTIKKARIMS LEESLEYLNEDEYCEVTPESIRLRKKILNKNEREKAAKKKKTAGLS*" /label="bipA CDS" gene 1433097..1434935 /gene="bipA" /locus_tag="BSU_14770" /old_locus_tag="BSU14770" /label="bipA gene" CDS 1434992..1435309 /gene="ylaH" /locus_tag="BSU_14780" /old_locus_tag="BSU14780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unkown function" /protein_id="NP_389361.1" /db_xref="EnsemblGenomes-Gn:BSU14780" /db_xref="EnsemblGenomes-Tr:CAB13351" /db_xref="GOA:O07632" /db_xref="InterPro:IPR025620" /db_xref="SubtiList:BG13345" /db_xref="UniProtKB/Swiss-Prot:O07632" /translation="MNDVSERLSFFAALYQVDRQPAAGMWLLYGTIFVLAVIVFKLGF AKRLPVLKSAVVYVFLALGCTVLTFLGVFLPVAEGLVVAALILIIYKIRLYQSKKGQS AKS*" /label="ylaH CDS" gene 1434992..1435309 /gene="ylaH" /locus_tag="BSU_14780" /old_locus_tag="BSU14780" /label="ylaH gene" downshifts 1435283 /Source="Nicolas_upshifts" /id="D834" /incds=0 /nref=241 /ntot=297 /MaxReadThrough="2.76511" /MaxDrop="7.50514" /score="29.8701447" /energy="-12.5" /TU="NA" /idTUdmin="U1227" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" downshifts complement(1435358) /Source="Nicolas_upshifts" /id="D835" /incds=0 /nref=240 /ntot=265 /MaxReadThrough="0.672690000000001" /MaxDrop="7.03405" /score="10.4340016" /energy="-12.5" /TU="NA" /idTUdmin="U1228" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1435365..1435574) /gene="ylaI" /locus_tag="BSU_14790" /old_locus_tag="BSU14790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389362.1" /db_xref="EnsemblGenomes-Gn:BSU14790" /db_xref="EnsemblGenomes-Tr:CAB13352" /db_xref="InterPro:IPR019241" /db_xref="SubtiList:BG13346" /db_xref="UniProtKB/Swiss-Prot:O07633" /translation="MMRVKCSICDKIETIDDDTLIAKRLRNRPIHTYMCQECHDRIAK KTEERLKTGKFTFHPGQQKKEKVKK*" /label="ylaI CDS" gene complement(1435365..1435574) /gene="ylaI" /locus_tag="BSU_14790" /old_locus_tag="BSU14790" /label="ylaI gene" misc_feature complement(1435588..1435607) /Source="Nicolas_upshift_promotors" /id="U1228" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.742257742257742" /psig=1 /xcortree=1900 /SigmaFactorBS="tgactaagctatagccttgcgctttagctttttcttattttg gacagcttctgatcCGTGGTATAATACATGTTAGtgaaagaggtgatatgatgagggt c" /listShort="ylaI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1435603) /Source="Nicolas_upshifts" /id="U1228" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.742257742257742" /psig=1 /xcortree=1900 /SigmaFactorBS="tgactaagctatagccttgcgctttagctttttcttattttg gacagcttctgatcCGTGGTATAATACATGTTAGtgaaagaggtgatatgatgagggt c" /listShort="ylaI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1435657..1436286) /gene="ylaJ" /locus_tag="BSU_14800" /old_locus_tag="BSU14800" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28333204; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative germination lipoprotein" /protein_id="NP_389363.1" /db_xref="EnsemblGenomes-Gn:BSU14800" /db_xref="EnsemblGenomes-Tr:CAB13353" /db_xref="GOA:O07634" /db_xref="InterPro:IPR014247" /db_xref="InterPro:IPR015943" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG13347" /db_xref="UniProtKB/Swiss-Prot:O07634" /translation="MRILFIIIQLTLILSACAYQQGKQGQNVEKESTRQQETKPIHVK DTTQETKDNGTRTDIAKHLVSVAEKNPDVKDATAVVLGGYAVVGIDVDDTLDRSKVET IKYSVAQALKNDRYGANAVVIADPDTVSRLREMSREISEGHPVTGILDELAAIVGRVL PEVPNDVIDNEDEPQTKQQNDQLNRKQQQEMEKEQNDQSDHHMKKNNND*" /label="ylaJ CDS" gene complement(1435657..1436286) /gene="ylaJ" /locus_tag="BSU_14800" /old_locus_tag="BSU14800" /label="ylaJ gene" downshifts complement(1435688) /Source="Nicolas_upshifts" /id="D836" /incds=0 /nref=57 /ntot=112 /MaxReadThrough="1.90936" /MaxDrop="5.8475" /score="3.85709048" /energy="-7.2" /TU="NA" /idTUdmin="U1229" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1436188..1436206) /Source="Nicolas_upshift_promotors" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1436194) /Source="Nicolas_upshifts" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1436218..1436226) /Source="Nicolas_upshift_promotors" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1436321..1436332) /Source="Nicolas_upshift_promotors" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1436326) /Source="Nicolas_upshifts" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1436338..1436343 /Source="Nicolas_upshift_promotors" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="promotor_-35" promotor_-35 complement(1436347..1436353) /Source="Nicolas_upshift_promotors" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1436359..1436377 /Source="Nicolas_upshift_promotors" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="promotor_-10" upshifts 1436359 /Source="Nicolas_upshifts" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="upshifts" S_feature 1436360..1436440 /Source="Nicolas_S_feature" /locus_tag="new_1549384_1549464" /HighExp="S3, S5, S4, S8, S6, S7, LoTm, T5.0H, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S538" CDS 1436441..1437769 /gene="ylaK" /locus_tag="BSU_14810" /old_locus_tag="BSU14810" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12762842, 17114254; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative phosphate starvation inducible protein" /protein_id="NP_389364.1" /db_xref="EnsemblGenomes-Gn:BSU14810" /db_xref="EnsemblGenomes-Tr:CAB13354" /db_xref="GOA:O07635" /db_xref="InterPro:IPR002716" /db_xref="InterPro:IPR003714" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029060" /db_xref="SubtiList:BG13348" /db_xref="UniProtKB/Swiss-Prot:O07635" /translation="MSKIYVLDTNVLLQDPNAIFSFEENEVVIPAVVLEEVDSKKRYM DEVGRNARHVSKLIDALRQKGRLHEHVPLDTGGTLRIELNHRSFHQLQEIFIEKTNDN RILAVAKNLSLEEETKENGRPVILVSKDVLVRVKADAIGLLAEDFLNDRVVDNDEMYS GYKDLYISQQLFSSFYGKNQISVNDVKQHAFYPNQFALMKDELGGSSSAVGIADKTGT VLKRLVFDDEHIWGIRPKNVQQTMALELLLREDIPLVTLIGKAGTGKTLLALAAGLLQ TEDLGIYKKLVVARPIVPVGKDIGYLPGEKEEKLKPWMQPIFDNLEFLFNAKKPGELD AILAGIGSIQVEALTYIRGRSIPDQFIIIDEAQNLTRHEVKTLLTRVGEGSKIVLMGD PEQIDHPYLDSLNNGLAYVVERFKGQPISGSVKLLKGERSGLAQLAADLL*" /label="ylaK CDS" gene 1436441..1437769 /gene="ylaK" /locus_tag="BSU_14810" /old_locus_tag="BSU14810" /label="ylaK gene" S_feature complement(1437625..1437772) /Source="Nicolas_S_feature" /locus_tag="new_1550649_1550796_c" /HighExp="M40t90, M0t90, dia15, Lbtran, dia5, Etha, Mt0, Gly, LBGtran, LPhT" /AntisenseName="ylaK" /AntisenseCor="-0.66426410013570203" /AntisenseRegPval="-34.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S539" downshifts complement(1437668) /Source="Nicolas_upshifts" /id="D837" /incds=1 /nref=6 /ntot=67 /MaxReadThrough="3.81309" /MaxDrop="3.44499" /score="3.85709048" /energy="-7.2" /TU="U1232" /idTUdmin="U1232" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" S_feature 1437770..1438360 /Source="Nicolas_S_feature" /locus_tag="new_1550794_1551384" /HighExp="S3, S4, S6, S5, S8, S7, BT, B36, LoTm, T5.0H" /AntisenseName="ylaL" /AntisenseCor="-0.79954210237955903" /AntisenseRegPval="-60.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S540" CDS complement(1437773..1438258) /gene="ylaL" /locus_tag="BSU_14820" /old_locus_tag="BSU14820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389365.1" /db_xref="EnsemblGenomes-Gn:BSU14820" /db_xref="EnsemblGenomes-Tr:CAB13355" /db_xref="GOA:O07636" /db_xref="InterPro:IPR020229" /db_xref="InterPro:IPR036374" /db_xref="SubtiList:BG13349" /db_xref="UniProtKB/Swiss-Prot:O07636" /translation="MSVIQVKGNVTYPITIDPSVWIFDDRKFSFDRKGDSQDTYLQSA GDESDLDPERVIREGRIAPPTLKTEKQYEKQKLMNGSFAMRLGTVLKNAEPNSSATQC VFVTSSGKAAVSLETALNSIVHFSEAGKPIQEGGPVHIYFEDPVHHKQPITDVKEIEI I*" /label="ylaL CDS" gene complement(1437773..1438258) /gene="ylaL" /locus_tag="BSU_14820" /old_locus_tag="BSU14820" /label="ylaL gene" promotor_-10 complement(1438270..1438289) /Source="Nicolas_upshift_promotors" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1438298) /Source="Nicolas_upshifts" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1438304..1438311) /Source="Nicolas_upshift_promotors" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1438361..1439290 /gene="glsB" /locus_tag="BSU_14830" /old_locus_tag="BSU14830" /EC_number="3.5.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:18459799" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18459799; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-glutamine amidohydrolase; glutaminase" /protein_id="NP_389366.1" /db_xref="EnsemblGenomes-Gn:BSU14830" /db_xref="EnsemblGenomes-Tr:CAB13356" /db_xref="GOA:O07637" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR015868" /db_xref="SubtiList:BG13350" /db_xref="UniProtKB/Swiss-Prot:O07637" /translation="MVCQHNDELEALVKKAKKVTDKGEVASYIPALAKADKHDLSVAI YYSNNVCLSAGDVEKTFTLQSISKVLSLALVLMEYGKDKVFSYVGQEPTGDPFNSIIK LETVNPSKPLNPMINAGALVVTSLIRGRTVKERLDYLLSFIRRLTNNQEITYCREVAE SEYSTSMINRAMCYYMKQYGIFEDDVEAVMDLYTKQCAIEMNSLDLAKIGSVFALNGR HPETGEQVISKDVARICKTFMVTCGMYNASGEFAIKVGIPAKSGVSGGIMGISPYDFG IGIFGPALDEKGNSIAGVKLLEIMSEMYRLSIF*" /label="glsB CDS" gene 1438361..1439290 /gene="glsB" /locus_tag="BSU_14830" /old_locus_tag="BSU14830" /label="glsB gene" misc_feature 1438875..1438894 /Source="Nicolas_upshift_promotors" /id="U1233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.9000999000999" /psig="0.99100899100899" /xcortree=596 /SigmaFactorBS="gccgggaagtggctgaatctgaatacagcacttcaatgatta atcgggcgaTGTGTTATTATATGAAGCAGtacggcatttttgaagatgatgtagaggc a" /GFF_Attribute="listShort" /listLong="ylaN" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1438884 /Source="Nicolas_upshifts" /id="U1233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.9000999000999" /psig="0.99100899100899" /xcortree=596 /SigmaFactorBS="gccgggaagtggctgaatctgaatacagcacttcaatgatta atcgggcgaTGTGTTATTATATGAAGCAGtacggcatttttgaagatgatgtagaggc a" /GFF_Attribute="listShort" /listLong="ylaN" /label="upshifts" promotor_-35 1439314..1439317 /Source="Nicolas_upshift_promotors" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1439332..1439351 /Source="Nicolas_upshift_promotors" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1439340 /Source="Nicolas_upshifts" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="upshifts" CDS 1439388..1439669 /gene="ylaN" /locus_tag="BSU_14840" /old_locus_tag="BSU14840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12682299, 16880555, 17005971,17469204" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389367.1" /db_xref="EnsemblGenomes-Gn:BSU14840" /db_xref="EnsemblGenomes-Tr:CAB13357" /db_xref="InterPro:IPR009983" /db_xref="InterPro:IPR036270" /db_xref="SubtiList:BG13351" /db_xref="UniProtKB/Swiss-Prot:O07638" /translation="MASEMIVDHRQKAFELLKVDAEKILKLIRVQMDNLTMPQCPLYE EVLDTQMFGLSREIDFAVRLGLVDEKDGKDLLYTLERELSALHDAFTAK*" /label="ylaN CDS" gene 1439388..1439669 /gene="ylaN" /locus_tag="BSU_14840" /old_locus_tag="BSU14840" /label="ylaN gene" downshifts 1439658 /Source="Nicolas_upshifts" /id="D838" /incds=0 /nref=72 /ntot=227 /MaxReadThrough="5.3857" /MaxDrop="6.58793" /score="2.26145837" /energy="-6.9" /TU="U1234" /idTUdmin="U1231" /TUdmin=328 /isTUend="FALSE" /label="downshifts" promotor_-35 1439732..1439735 /Source="Nicolas_upshift_promotors" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1439748..1439874 /Source="Nicolas_S_feature" /locus_tag="new_1552772_1552898" /HighExp="S1, T5.0H, T4.0H, HiOs, T3.30H, T3.0H, Etha, Heat, T2.0H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI, SigA" /TUshortPSig="0.619, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S541" upshifts 1439748 /Source="Nicolas_upshifts" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1439753..1439759 /Source="Nicolas_upshift_promotors" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1439875..1441086 /gene="ftsW" /locus_tag="BSU_14850" /old_locus_tag="BSU14850" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9622350, 12626683, 15849754, 16850406, 21386816, 27895631" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 12626683, 15849754, 16850406, 21386816, 27895631; Product type t : transporter" /codon_start=1 /transl_table=11 /product="cell-division protein; transporter of lipid-linked cell wall precursors" /protein_id="NP_389368.1" /db_xref="EnsemblGenomes-Gn:BSU14850" /db_xref="EnsemblGenomes-Tr:CAB13358" /db_xref="GOA:O07639" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG13352" /db_xref="UniProtKB/Swiss-Prot:O07639" /translation="MLKKMLKSYDYSLIFAIVLLCGFGLVMVYSSSMITAVSRYGVSS NFFFMRQLFALIAGGALFILMALFPYKALAHQKFQKGILLVSVLALISLFVFGHVAGN AQSWFKIGGMSIQPGEFVKLVVILYLAAVYAKKQSYIDHLLTGVAPPVVMTLIICGLI AMQPDFGTAMIIGLIATCMILCSGFSGKTLVRLVILGGIVFILVSPIIYLNQDKILTE GRLARFESLEDPFKYANSSGLQVINSYYAISSGGIFGLGLGESIQKYGYLPESHTDFI MAVIAEELGIFGVLFVIFLLGFVVIKGFYIARKCEDPFGSLLAIGISSMIAIQSFINL GGVSGLIPITGVTLPFISYGGSSLVLLLGSMGILANISMFVKYSENKKKKEPLAPKGM KKKQLKKTVYL*" /label="ftsW CDS" gene 1439875..1441086 /gene="ftsW" /locus_tag="BSU_14850" /old_locus_tag="BSU14850" /label="ftsW gene" promotor_-35 1441096..1441100 /Source="Nicolas_upshift_promotors" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1441115..1441134 /Source="Nicolas_upshift_promotors" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1441134 /Source="Nicolas_upshifts" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="upshifts" CDS 1441161..1444607 /gene="pycA" /locus_tag="BSU_14860" /old_locus_tag="BSU14860" /EC_number="6.4.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6425269, 15134465, 20081037, 20097852; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate carboxylase" /protein_id="NP_389369.1" /db_xref="EnsemblGenomes-Gn:BSU14860" /db_xref="EnsemblGenomes-Tr:CAB13359" /db_xref="GOA:Q9KWU4" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR003379" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR005930" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG12660" /db_xref="UniProtKB/Swiss-Prot:Q9KWU4" /translation="MSQQSIQKVLVANRGEIAIRIFRACTELNIRTVAVYSKEDSGSY HRYKADEAYLVGEGKKPIDAYLDIEGIIDIAKRNKVDAIHPGYGFLSENIHFARRCEE EGIVFIGPKSEHLDMFGDKVKAREQAEKAGIPVIPGSDGPAETLEAVEQFGQANGYPI IIKASLGGGGRGMRIVRSESEVKEAYERAKSEAKAAFGNDEVYVEKLIENPKHIEVQV IGDKQGNVVHLFERDCSVQRRHQKVIEVAPSVSLSPELRDQICEAAVALAKNVNYINA GTVEFLVANNEFYFIEVNPRVQVEHTITEMITGVDIVQTQILVAQGHSLHSKKVNIPE QKDIFTIGYAIQSRVTTEDPQNDFMPDTGKIMAYRSGGGFGVRLDTGNSFQGAVITPY YDSLLVKLSTWALTFEQAAAKMVRNLQEFRIRGIKTNIPFLENVAKHEKFLTGQYDTS FIDTTPELFNFPKQKDRGTKMLTYIGNVTVNGFPGIGKKEKPAFDKPLGVKVDVDQQP ARGTKQILDEKGAEGLANWVKEQKSVLLTDTTFRDAHQSLLATRIRSHDLKKIANPTA ALWPELFSMEMWGGATFDVAYRFLKEDPWKRLEDLRKEVPNTLFQMLLRSSNAVGYTN YPDNVIKEFVKQSAQSGIDVFRIFDSLNWVKGMTLAIDAVRDTGKVAEAAICYTGDIL DKNRTKYDLAYYTSMAKELEAAGAHILGIKDMAGLLKPQAAYELVSALKETIDIPVHL HTHDTSGNGIYMYAKAVEAGVDIIDVAVSSMAGLTSQPSASGFYHAMEGNDRRPEMNV QGVELLSQYWESVRKYYSEFESGMKSPHTEIYEHEMPGGQYSNLQQQAKGVGLGDRWN EVKEMYRRVNDMFGDIVKVTPSSKVVGDMALYMVQNNLTEKDVYEKGESLDFPDSVVE LFKGNIGQPHGGFPEKLQKLILKGQEPITVRPGELLEPVSFEAIKQEFKEQHNLEISD QDAVAYALYPKVFTDYVKTTESYGDISVLDTPTFFYGMTLGEEIEVEIERGKTLIVKL ISIGEPQPDATRVVYFELNGQPREVVIKDESIKSSVQERLKADRTNPSHIAASMPGTV IKVLAEAGTKVNKGDHLMINEAMKMETTVQAPFSGTIKQVHVKNGEPIQTGDLLLEIE KA*" /label="pycA CDS" gene 1441161..1444607 /gene="pycA" /locus_tag="BSU_14860" /old_locus_tag="BSU14860" /label="pycA gene" promotor_-10 complement(1444173..1444191) /Source="Nicolas_upshift_promotors" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1444193) /Source="Nicolas_upshifts" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1444207..1444212) /Source="Nicolas_upshift_promotors" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1444587 /Source="Nicolas_upshifts" /id="D839" /incds=0 /nref=20 /ntot=213 /MaxReadThrough="5.5667" /MaxDrop="6.03063" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts 1444632 /Source="Nicolas_upshifts" /id="D840" /incds=0 /nref=2 /ntot=51 /MaxReadThrough="4.21552" /MaxDrop="4.9051" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin=44 /isTUend="FALSE" /label="downshifts" downshifts complement(1444664) /Source="Nicolas_upshifts" /id="D841" /incds=0 /nref=2 /ntot=10 /MaxReadThrough="2.24992" /MaxDrop="3.11732" /score="10.1921506" /energy="-11.8" /TU="NA" /idTUdmin="U1238" /TUdmin=330 /isTUend="FALSE" /label="downshifts" downshifts 1444676 /Source="Nicolas_upshifts" /id="D842" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="3.6246" /MaxDrop="4.10361" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin=88 /isTUend="FALSE" /label="downshifts" CDS complement(1445010..1445930) /gene="ctaA" /locus_tag="BSU_14870" /old_locus_tag="BSU14870" /EC_number="1.3.-.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12206660, 15491161, 15849754, 16321940, 16850406, 26592143" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12206660, 15491161, 15849754, 16321940, 16850406, 26592143; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heme-A synthase" /protein_id="NP_389370.1" /db_xref="EnsemblGenomes-Gn:BSU14870" /db_xref="EnsemblGenomes-Tr:CAB13360" /db_xref="GOA:P12946" /db_xref="InterPro:IPR003780" /db_xref="InterPro:IPR023755" /db_xref="SubtiList:BG10213" /db_xref="UniProtKB/Swiss-Prot:P12946" /translation="MNKALKALGVLTTFVMLIVLIGGALVTKTGSGQGCGRQWPLCHG RFFPELNPASIIEWSHRFASGISIILVLSLAFWSWRKITPIFRETTFLAIMSIIFLFL QALLGALAVVFGSNALIMALHFGISLISFASVLILTLLIFEADKSVRTLVKPLQIGKK MQFHMIGILIYSYIVVYTGAYVRHTESSLACPNVPLCSPLNNGLPTQFHEWVQMGHRA AALLLFVWIIVAAVHAITSYKDQKQIFWGWISCLIFITLQALSGIMIVYSELALGFAL AHSFFIACLFGVLCYFLLLIARFRYESRQS*" /label="ctaA CDS" gene complement(1445010..1445930) /gene="ctaA" /locus_tag="BSU_14870" /old_locus_tag="BSU14870" /label="ctaA gene" downshifts complement(1445016) /Source="Nicolas_upshifts" /id="D843" /incds=0 /nref=126 /ntot=238 /MaxReadThrough="2.72676" /MaxDrop="5.67271" /score="28.8671863" /energy="-15.3" /TU="U1238" /idTUdmin="U1238" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1445970..1445989) /Source="Nicolas_upshift_promotors" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1445985) /Source="Nicolas_upshifts" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1446003..1446010) /Source="Nicolas_upshift_promotors" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1446065..1446072 /Source="Nicolas_upshift_promotors" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1446086..1446105 /Source="Nicolas_upshift_promotors" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1446087..1446192 /Source="Nicolas_S_feature" /locus_tag="new_1559111_1559216" /HighExp="LBGstat, M0t90, Lbstat, BC, T0.30H, T1.30H, B60, M9-stat, M40t90, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S542" upshifts 1446087 /Source="Nicolas_upshifts" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" S_feature 1446194..1446284 /Source="Nicolas_S_feature" /locus_tag="new_1559218_1559308" /HighExp="LBGstat, M0t90, LPhT, BC, UNK1, BI, Lbexp, LBGtran, Lbstat, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S543" upshifts 1446194 /Source="Nicolas_upshifts" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1446200..1446203 /Source="Nicolas_upshift_promotors" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1446218..1446234 /Source="Nicolas_upshift_promotors" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1446285..1447202 /gene="ctaB" /locus_tag="BSU_14880" /old_locus_tag="BSU14880" /EC_number="2.5.1.-" /function="16.10: Respire" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8082800, 10675592, 15849754, 16850406, 7968515, 9829923, 19204012" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8082800, 10675592, 15849754, 16850406, 7968515, 9829923, 19204012; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protoheme IX farnesyltransferase 2" /protein_id="NP_389371.1" /db_xref="EnsemblGenomes-Gn:BSU14880" /db_xref="EnsemblGenomes-Tr:CAB13361" /db_xref="GOA:P24009" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR006369" /db_xref="InterPro:IPR030470" /db_xref="SubtiList:BG10214" /db_xref="UniProtKB/Swiss-Prot:P24009" /translation="MANSRILNDTAIDGQIEETTAWKDFLSLIKIGIVNSNLITTFTG MWLALHISGLSFLGNINTVLLTLIGSSLIIAGSCAINNWYDRDIDHLMERTKVRPTVT GKIQPSQALWSGILLVALGLIMLLMTTVMAAVIGFIGVFTYVVLYTMWTKRRYTINTV VGSVSGAVPPLIGWTAVEGNIGVVAWVLFMILFIWQIPHFLALAIKKTEDYRAANIPM LPVVYGFEVTKRQIIVWVACLMPLPFFLGSLGLPIVILGLLLNIGWLILGLMGFRSKN IMKWATQMFVYSLNYMTIYFVAMVVLTLF*" /label="ctaB CDS" gene 1446285..1447202 /gene="ctaB" /locus_tag="BSU_14880" /old_locus_tag="BSU14880" /label="ctaB gene" downshifts 1447231 /Source="Nicolas_upshifts" /id="D844" /incds=0 /nref=33 /ntot=75 /MaxReadThrough="8.35391" /MaxDrop="5.6457" /score="0.893081758" /energy="-11.8" /TU="U1239,U1240" /idTUdmin="U1236" /TUdmin=1719 /isTUend="FALSE" /label="downshifts" upshifts 1447250 /Source="Nicolas_upshifts" /id="U1241" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.406593406593407" /xcortree=510 /SigmaFactorBS="gacgcttttctaaaaaatagatatgatgcttgttttatcgct tcaaaataaacgatgacaaCTAGTAaatgccgccttgacctcttgtttaatcaggcgg c" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1447251..1447256 /Source="Nicolas_upshift_promotors" /id="U1241" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.406593406593407" /xcortree=510 /SigmaFactorBS="gacgcttttctaaaaaatagatatgatgcttgttttatcgct tcaaaataaacgatgacaaCTAGTAaatgccgccttgacctcttgtttaatcaggcgg c" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1447310..1447315 /Source="Nicolas_upshift_promotors" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1447330..1447348 /Source="Nicolas_upshift_promotors" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1447338..1447441 /Source="Nicolas_S_feature" /locus_tag="new_1560362_1560465" /HighExp="Lbstat, M0t90, M40t90, T2.30H, T3.30H, T2.0H, T3.0H, T4.0H, T1.30H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, Sig-, SigA, SigA" /TUshortPSig="0.451, 0.407, 0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S544" upshifts 1447338 /Source="Nicolas_upshifts" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" CDS 1447442..1448512 /gene="ctaC" /locus_tag="BSU_14890" /old_locus_tag="BSU14890" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 9829923, 9882689, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 9829923, 9882689, 27503613; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit II)" /protein_id="NP_389372.1" /db_xref="EnsemblGenomes-Gn:BSU14890" /db_xref="EnsemblGenomes-Tr:CAB13362" /db_xref="GOA:P24011" /db_xref="InterPro:IPR001505" /db_xref="InterPro:IPR002429" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR011759" /db_xref="InterPro:IPR014222" /db_xref="InterPro:IPR034236" /db_xref="InterPro:IPR036257" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG10215" /db_xref="UniProtKB/Swiss-Prot:P24011" /translation="MVKHWRLILLLALVPLLLSGCGKPFLSTLKPAGEVADKQYDLTV LSTLIMVVVVAVVSVIFFYVIVRFRRSRVGENTIPKQVEGNKFLEITWTVIPILLLII LVIPVVLYTLELADTSPMDKKGRKAEDALVVNVRANLYWWEFEYPDYGIITSQELIVP TDQRVYFNLKASDVKHSFWIPSVGGKLDTNTDNENKFFLTFDSKRSKEAGDMFFGKCA ELCGPSHALMDFKVKTMSAKEFQGWTKEMKNYKSTAESDLAKQGEELFKEKNCLSCHA VEPNDKRAEAARTAPNLATFGERTKVAGVKEANKENVKAWLKDPDSIKPGNKMTGTYP KLSDSETNALYEYLKGLKAESK*" /label="ctaC CDS" gene 1447442..1448512 /gene="ctaC" /locus_tag="BSU_14890" /old_locus_tag="BSU14890" /label="ctaC gene" CDS 1448545..1450413 /gene="ctaD" /locus_tag="BSU_14900" /old_locus_tag="BSU14900" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit I)" /protein_id="NP_389373.2" /db_xref="EnsemblGenomes-Gn:BSU14900" /db_xref="EnsemblGenomes-Tr:CAB13363" /db_xref="GOA:P24010" /db_xref="InterPro:IPR000883" /db_xref="InterPro:IPR014241" /db_xref="InterPro:IPR023615" /db_xref="InterPro:IPR023616" /db_xref="InterPro:IPR036927" /db_xref="SubtiList:BG10216" /db_xref="UniProtKB/Swiss-Prot:P24010" /translation="MLNALTEKRTRGSMLWDYLTTVDHKKIAILYLVAGGFFFLVGGI EAMFIRIQLAKPENAFLSAQAYNEVMTMHGTTMIFLAAMPLLFALMNAVVPLQIGARD VSFPFLNALGFWLFFFGGIFLNLSWFLGGAPDAGWTSYASLSLHSKGHGIDFFVLGLQ ISGLGTLIAGINFLATIINMRAPGMTYMRLPLFTWTTFVASALILFAFPPLTVGLALM MLDRLFGTNFFNPELGGNTVIWEHLFWIFGHPEVYILILPAFGIFSEVIPVFARKRLF GYSSMVFAIVLIGFLGFMVWVHHMFTTGLGPIANAIFAVATMAIAIPTGIKIFNWLLT IWGGNVKYTTAMLYAVSFIPSFVLGGVTGVMLAAAAADYQFHDTYFVVAHFHYVIIGG VVFGLLAGVHFWWPKMFGKILHETMGKISFVLFFIGFHLTFFIQHFVGLMGMPRRVYT FLPGQGLETGNLISTIGAFFMAAAVILLLVNVIWTSVKGEYVGADPWHDGRTLEWTVS SPPPEYNFKQLPFVRGLDPLWIEKQAGHKSMTPAEPVDDIHMPNGSILPLIISFGLFV AAFGLLYRSDYAWGLPVIFIGLGITFITMLLRSVIDDHGYHIHKEELPNDDKGVKA*" /label="ctaD CDS" gene 1448545..1450413 /gene="ctaD" /locus_tag="BSU_14900" /old_locus_tag="BSU14900" /label="ctaD gene" CDS 1450413..1451036 /gene="ctaE" /locus_tag="BSU_14910" /old_locus_tag="BSU14910" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit III)" /protein_id="NP_389374.1" /db_xref="EnsemblGenomes-Gn:BSU14910" /db_xref="EnsemblGenomes-Tr:CAB13364" /db_xref="GOA:P24012" /db_xref="InterPro:IPR000298" /db_xref="InterPro:IPR013833" /db_xref="InterPro:IPR024791" /db_xref="InterPro:IPR033946" /db_xref="InterPro:IPR035973" /db_xref="SubtiList:BG10217" /db_xref="UniProtKB/Swiss-Prot:P24012" /translation="MQVQEKFTAETFPASPEKVTLEGKNKFLGFWLFLGGETVLFASL FATFLALRNSNAGDPPTTEMFDVTLVFIATMLLLTSSLTSVYAMYHMKNFSFGKMQLW LGITILLGAGFLGLEIYEFKHYTHEFGFTITSSALGSAFYTLVGTHGAHVAFGLMWIS TLMIRNAKRGLNLYTAPKFYVASLYWHFIDVVWVFIFTVVYLMGMVG*" /label="ctaE CDS" gene 1450413..1451036 /gene="ctaE" /locus_tag="BSU_14910" /old_locus_tag="BSU14910" /label="ctaE gene" CDS 1451039..1451371 /gene="ctaF" /locus_tag="BSU_14920" /old_locus_tag="BSU14920" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit IV)" /protein_id="NP_389375.1" /db_xref="EnsemblGenomes-Gn:BSU14920" /db_xref="EnsemblGenomes-Tr:CAB13365" /db_xref="GOA:P24013" /db_xref="InterPro:IPR005171" /db_xref="InterPro:IPR014257" /db_xref="SubtiList:BG10218" /db_xref="UniProtKB/Swiss-Prot:P24013" /translation="MVDKKSRGHINSDLEFKKKKHAREMKYQVLSFGLMIGLTIVAFL TVATDGVGSWFTIPFIILLAAIQVIFQLYYFMHMNQKGHEAPALFLYSGVFVAFITVL AFVTIIWW*" /label="ctaF CDS" gene 1451039..1451371 /gene="ctaF" /locus_tag="BSU_14920" /old_locus_tag="BSU14920" /label="ctaF gene" CDS 1451398..1452291 /gene="ctaG" /locus_tag="BSU_14930" /old_locus_tag="BSU14930" /function="16.10: Respire" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14766920, 15849754, 16305244, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14766920, 15849754, 16305244, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="cytochrome aa(3) assembly factor" /protein_id="NP_389376.1" /db_xref="EnsemblGenomes-Gn:BSU14930" /db_xref="EnsemblGenomes-Tr:CAB13366" /db_xref="GOA:O34329" /db_xref="InterPro:IPR014108" /db_xref="InterPro:IPR019108" /db_xref="SubtiList:BG12579" /db_xref="UniProtKB/Swiss-Prot:O34329" /translation="MNQLEIFGFRAMWSPYLFCILLGITALYLYFYRRMSSKPNRITG KEMVCFLSAMLFLYAAEGSPVDLLGHIMFSAHMVQMAVLYLVVPPLLIAGIPAWLWEK IIFRPSIKPVFSFFTTPLIALLLFNGIFSLYHVPLIFDTVKTDPFYHTLITWLIFVLA FFMWWPLVHKVERLRQLSGLMKLGYIMADGMLLTPACALIMFSGAPLYATYTDPALWA EAMRLCVPADMMGQVPLTGPEMLNTLPLLEDQQLGAVMMKIIQEIVYGTFLAVIFFQW VKKEREKDGQEEPPYIQQTIS*" /label="ctaG CDS" gene 1451398..1452291 /gene="ctaG" /locus_tag="BSU_14930" /old_locus_tag="BSU14930" /label="ctaG gene" downshifts 1452266 /Source="Nicolas_upshifts" /id="D845" /incds=0 /nref=121 /ntot=229 /MaxReadThrough="1.94099" /MaxDrop="5.91271" /score="4.35633365" /energy="-13.3" /TU="NA" /idTUdmin="U1239" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1452323..1452685) /gene="ylbA" /locus_tag="BSU_14940" /old_locus_tag="BSU14940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389377.1" /db_xref="EnsemblGenomes-Gn:BSU14940" /db_xref="EnsemblGenomes-Tr:CAB13367" /db_xref="InterPro:IPR014967" /db_xref="InterPro:IPR036491" /db_xref="SubtiList:BG13353" /db_xref="UniProtKB/Swiss-Prot:O34743" /translation="MLKFTESGLEGVKAELSWLDDLMESKGLIRAGQWDYERVTYDKK FSTIEGTFYLRIQGIAAEGDVGSGRAVIQLMSPLLGKHYYPHGVEYGETEEFPVQVVT KSKALIQDIANMLKTVQM*" /label="ylbA CDS" gene complement(1452323..1452685) /gene="ylbA" /locus_tag="BSU_14940" /old_locus_tag="BSU14940" /label="ylbA gene" downshifts complement(1452342) /Source="Nicolas_upshifts" /id="D846" /incds=0 /nref=217 /ntot=257 /MaxReadThrough="1.00586" /MaxDrop="6.68145" /score="-3.42191479" /energy="-11.2" /TU="NA" /idTUdmin="U1244" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1452678..1452682 /Source="Nicolas_upshift_promotors" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1452691..1452704 /Source="Nicolas_upshift_promotors" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1452709..1452728) /Source="Nicolas_upshift_promotors" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1452713..1452824 /Source="Nicolas_S_feature" /locus_tag="new_1565737_1565848" /HighExp="S7, S8, S4, S3, S6, S5, T5.0H, T4.0H, BC, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.368" /TUlongSig="NA" /TUlongPSig="NA" /label="S545" upshifts 1452713 /Source="Nicolas_upshifts" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1452721) /Source="Nicolas_upshifts" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1452743..1452750) /Source="Nicolas_upshift_promotors" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1452825..1453271 /gene="ylbB" /locus_tag="BSU_14950" /old_locus_tag="BSU14950" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389378.2" /db_xref="EnsemblGenomes-Gn:BSU14950" /db_xref="EnsemblGenomes-Tr:CAB13368" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG13354" /db_xref="UniProtKB/Swiss-Prot:O34682" /translation="MTKIKDLMTADLQYCTVLDNVYEAAVKMKDANVGAIPVVDEDGE TLVGIVTDRDLVLRGIAIKKPNSQKITDAMTEKPVSVEEDASVDEVLHLMASHQLRRI PVTKNKKLTGIVTLGDLSLSEQTNERAGSALSDISEGDNREEGFFH*" /label="ylbB CDS" gene 1452825..1453271 /gene="ylbB" /locus_tag="BSU_14950" /old_locus_tag="BSU14950" /label="ylbB gene" promotor_-35 1452857..1452864 /Source="Nicolas_upshift_promotors" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1452876..1452895 /Source="Nicolas_upshift_promotors" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1452881 /Source="Nicolas_upshifts" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1453280..1453287 /Source="Nicolas_upshift_promotors" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1453301..1453320 /Source="Nicolas_upshift_promotors" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1453312 /Source="Nicolas_upshifts" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="upshifts" CDS 1453355..1454395 /gene="ylbC" /locus_tag="BSU_14960" /old_locus_tag="BSU14960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389379.1" /db_xref="EnsemblGenomes-Gn:BSU14960" /db_xref="EnsemblGenomes-Tr:CAB13369" /db_xref="GOA:O34586" /db_xref="InterPro:IPR014044" /db_xref="InterPro:IPR029410" /db_xref="InterPro:IPR035940" /db_xref="SubtiList:BG13355" /db_xref="UniProtKB/Swiss-Prot:O34586" /translation="MKNILRAMVILLIICGTYVLFIQYGSVPEKKSNDSEPQVSNEEA QSGKRIHMPTSGLLSFMGKHADEVTKKLGEPERIDPSAYDYDWWVYNQGKDQYIQIGV LNNKVVTLFASGNDINAKPFKIGESTGEVFKTTQVAPFVNVEYKGNSYRFEFSEEDIN TRPTVKVGKMYVQLYMDKFEGKLSSIRAFDAQTFVKQRPYEVVYRGELIKPKAVSDEK WKKIQTTSEKQILDLTNVIRVKHGLAKLEWDQPTAEVAFGHSEDMKENNYFSHVSKKY GSLKDRLEEGHVDFQQAGENIAYNYVDGPAAVEGWLNSEGHRKALLNSDYTHLGVGVD RKYYTQNFIKRW*" /label="ylbC CDS" gene 1453355..1454395 /gene="ylbC" /locus_tag="BSU_14960" /old_locus_tag="BSU14960" /label="ylbC gene" promotor_-10 complement(1454318..1454336) /Source="Nicolas_upshift_promotors" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1454323) /Source="Nicolas_upshifts" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1454352..1454357) /Source="Nicolas_upshift_promotors" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1454375 /Source="Nicolas_upshifts" /id="D847" /incds=0 /nref=84 /ntot=252 /MaxReadThrough="1.59604" /MaxDrop="4.17709" /score="-1.16631837" /energy="-8.1" /TU="NA" /idTUdmin="U1243" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-35 1454559..1454568 /Source="Nicolas_upshift_promotors" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1454582..1454601 /Source="Nicolas_upshift_promotors" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1454596 /Source="Nicolas_upshifts" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="upshifts" CDS 1454627..1455025 /gene="ylbD" /locus_tag="BSU_14970" /old_locus_tag="BSU14970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19775244, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-related protein (coat)" /protein_id="NP_389380.1" /db_xref="EnsemblGenomes-Gn:BSU14970" /db_xref="EnsemblGenomes-Tr:CAB13370" /db_xref="InterPro:IPR025953" /db_xref="SubtiList:BG13356" /db_xref="UniProtKB/Swiss-Prot:O34880" /translation="MANQHANHSINDFKQFVKKHPKLIKEVRKEQRSWQDVYENWVLF GESDPIWDPYREPEEASEAVPETPQKNDFVSKMVTAVKKMDVNQMNEQINKMSQSISS LQSLLNTFSGSGQKHSQPGSGQHPFSFRKD*" /label="ylbD CDS" gene 1454627..1455025 /gene="ylbD" /locus_tag="BSU_14970" /old_locus_tag="BSU14970" /label="ylbD gene" downshifts complement(1454631) /Source="Nicolas_upshifts" /id="D848" /incds=0 /nref=2 /ntot=11 /MaxReadThrough="2.37349" /MaxDrop="4.0378" /score="40.2648817" /energy="-14.3" /TU="NA" /idTUdmin="U1247" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS 1455041..1455280 /gene="ylbE" /locus_tag="BSU_14980" /old_locus_tag="BSU14980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22882546" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389381.1" /db_xref="EnsemblGenomes-Gn:BSU14980" /db_xref="EnsemblGenomes-Tr:CAB13371" /db_xref="InterPro:IPR025613" /db_xref="SubtiList:BG13357" /db_xref="UniProtKB/Swiss-Prot:O34958" /translation="MRKEVQEYILANEERKRFIREQPIWYRRLSRKPDDLSSFQLEMM NFYEKTIPHRVNQFTNGIQMAQMMMQMFQAMRTKD*" /label="ylbE CDS" gene 1455041..1455280 /gene="ylbE" /locus_tag="BSU_14980" /old_locus_tag="BSU14980" /label="ylbE gene" downshifts 1455259 /Source="Nicolas_upshifts" /id="D849" /incds=0 /nref=3 /ntot=17 /MaxReadThrough="2.09257" /MaxDrop="4.65792" /score="-7.8200921" /energy="-5.1" /TU="NA" /idTUdmin="U1248" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1455347..1455354 /Source="Nicolas_upshift_promotors" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1455365..1455384 /Source="Nicolas_upshift_promotors" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1455370 /Source="Nicolas_upshifts" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="upshifts" CDS 1455396..1455845 /gene="ricF" /locus_tag="BSU_14990" /old_locus_tag="BSU14990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10712692, 15175311, 15661000, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10712692, 15175311, 15661000, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="subunit of a sporulation, competence and biofilmformation regulatory complex controlling RNase Y (RicAFTcomplex / FAD / two [4Fe-4S]2+)" /protein_id="NP_389382.1" /db_xref="EnsemblGenomes-Gn:BSU14990" /db_xref="EnsemblGenomes-Tr:CAB13372" /db_xref="GOA:O34412" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR023378" /db_xref="SubtiList:BG13358" /db_xref="UniProtKB/Swiss-Prot:O34412" /translation="MYATMESVRLQSEAQQLAEMILQSETAENYRNCYKRLQEDEEAG RIIRSFIKIKEQYEDVQRFGKYHPDYREISRKMREIKRELDLNDKVADFKRAENELQS ILDEVSVEIGTAVSEHVKVPTGNPYFDGLSSCGGGCGSGGSCGCKVS*" /label="ricF CDS" gene 1455396..1455845 /gene="ricF" /locus_tag="BSU_14990" /old_locus_tag="BSU14990" /label="ricF gene" downshifts 1455831 /Source="Nicolas_upshifts" /id="D850" /incds=0 /nref=1 /ntot=6 /MaxReadThrough="5.95111" /MaxDrop="2.83" /score="-4.2014677" /energy="-11.5" /TU="U1249" /idTUdmin="U1248" /TUdmin=572 /isTUend="FALSE" /label="downshifts" CDS 1455900..1456172 /gene="ylbG" /locus_tag="BSU_15000" /old_locus_tag="BSU15000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10712692, 21532344, 22333191" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389383.1" /db_xref="EnsemblGenomes-Gn:BSU15000" /db_xref="EnsemblGenomes-Tr:CAB13373" /db_xref="GOA:O34658" /db_xref="InterPro:IPR016979" /db_xref="SubtiList:BG13359" /db_xref="UniProtKB/Swiss-Prot:O34658" /translation="MENRRQGMVVYLHSLKQSKMLRKFGNVHYVSKRLKYVVLYCDMD QIEKTMDKIASYSFVKKVEPSYKPFLKLEFESKLDKAKEYDYKIGI*" /label="ylbG CDS" gene 1455900..1456172 /gene="ylbG" /locus_tag="BSU_15000" /old_locus_tag="BSU15000" /label="ylbG gene" S_feature complement(1455977..1456200) /Source="Nicolas_S_feature" /locus_tag="new_1569001_1569224_c" /HighExp="S8, S7, S4, S5, S6, S3, C30, BT, G135, C90" /AntisenseName="ylbG" /AntisenseCor="-0.668594452827031" /AntisenseRegPval="-35.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.537" /TUlongSig="NA" /TUlongPSig="NA" /label="S546" misc_RNA 1456175..1456295 /gene="csfG" /locus_tag="BSU_misc_RNA_23" /product="sporulation-specific regulatory RNA" /experiment="publication(s) with functional evidences, PMID:21532344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21532344; Product type n: RNA" /function="15.7: Sporulation and germination" /label="csfG RNA" gene 1456175..1456295 /gene="csfG" /locus_tag="BSU_misc_RNA_23" /label="csfG gene" S_feature complement(1456202..1456325) /Source="Nicolas_S_feature" /locus_tag="new_1569226_1569349_c" /HighExp="S3, S8, S7, G/S, S4, S5, Pyr, S6, B36, BT" /AntisenseName="NA" /AntisenseCor="-0.69279578575099399" /AntisenseRegPval="-39.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.537" /TUlongSig="NA" /TUlongPSig="NA" /label="S547" downshifts complement(1456245) /Source="Nicolas_upshifts" /id="D851" /incds=0 /nref=61 /ntot=131 /MaxReadThrough="3.9368" /MaxDrop="7.78892" /score="40.2648817" /energy="-14.3" /TU="U1250" /idTUdmin="U1250" /TUdmin="-228" /isTUend="FALSE" /label="downshifts" S_feature 1456296..1456401 /Source="Nicolas_S_feature" /locus_tag="new_1569320_1569425" /HighExp="H2O2, Paraq, Oxctl, G180, G135, G150, Cold, C30, Diami, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S548" promotor_-10 complement(1456326..1456338) /Source="Nicolas_upshift_promotors" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1456333) /Source="Nicolas_upshifts" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1456353..1456359) /Source="Nicolas_upshift_promotors" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1456382..1456386 /Source="Nicolas_upshift_promotors" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="promotor_-35" promotor_-10 1456402..1456421 /Source="Nicolas_upshift_promotors" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="promotor_-10" S_feature 1456403..1456494 /Source="Nicolas_S_feature" /locus_tag="new_1569427_1569518" /HighExp="H2O2, G135, Oxctl, Paraq, G180, dia0, G150, Lbexp, LBGexp, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S549" upshifts 1456403 /Source="Nicolas_upshifts" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="upshifts" CDS 1456495..1457049 /gene="rsmD" /locus_tag="BSU_15010" /old_locus_tag="BSU15010" /EC_number="2.1.1.171" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 17389639, 22535590, 22649054; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA m2G966 methyltransferase" /protein_id="NP_389384.2" /db_xref="EnsemblGenomes-Gn:BSU15010" /db_xref="EnsemblGenomes-Tr:CAB13374" /db_xref="GOA:O34331" /db_xref="InterPro:IPR004398" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13360" /db_xref="UniProtKB/Swiss-Prot:O34331" /translation="MRVISGSKKGRSLKAVAGTSTRPTTDKVKESIFNMIGPYFDGGR GLDLFAGSGGLGIEALSRGFEHCIFVDRDFKAIQTVKSNLKTLELTKHAQVYRNDAER ALHAAAKRETGFRGIFLDPPYKEQKLKALLTLIDEYQMLEEDGFIVAEHDREVELPET VGDLVMTRKETYGLTGVAIYKKRG*" /label="rsmD CDS" gene 1456495..1457049 /gene="rsmD" /locus_tag="BSU_15010" /old_locus_tag="BSU15010" /label="rsmD gene" CDS 1457054..1457539 /gene="coaD" /locus_tag="BSU_15020" /old_locus_tag="BSU15020" /EC_number="2.7.7.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10480925, 10939241, 16014871, 21912874; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphopantetheine adenylyltransferase" /protein_id="NP_389385.1" /db_xref="EnsemblGenomes-Gn:BSU15020" /db_xref="EnsemblGenomes-Tr:CAB13375" /db_xref="GOA:O34797" /db_xref="InterPro:IPR001980" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="PDB:1O6B" /db_xref="SubtiList:BG13361" /db_xref="UniProtKB/Swiss-Prot:O34797" /translation="MASIAVCPGSFDPVTYGHLDIIKRGAHIFEQVYVCVLNNSSKKP LFSVEERCELLREVTKDIPNITVETSQGLLIDYAKRKNAKAILRGLRAVSDFEYEMQG TSVNRVLDESIETFFMMTNNQYSFLSSSIVKEVARYNGSVSEFVPPEVELALQQKFRQ G*" /label="coaD CDS" gene 1457054..1457539 /gene="coaD" /locus_tag="BSU_15020" /old_locus_tag="BSU15020" /label="coaD gene" downshifts 1457506 /Source="Nicolas_upshifts" /id="D852" /incds=0 /nref=26 /ntot=196 /MaxReadThrough="3.45558" /MaxDrop="3.85134" /score="13.7782945" /energy="-7.8" /TU="U1249,U1251" /idTUdmin="U1251" /TUdmin="-1296" /isTUend="FALSE" /label="downshifts" CDS complement(1457550..1458776) /gene="spoVV" /locus_tag="BSU_15030" /old_locus_tag="BSU15030" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15849754, 16850406, 28945739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15849754, 16850406, 28945739; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipicolinic acid transporter (to the spore)" /protein_id="NP_389386.1" /db_xref="EnsemblGenomes-Gn:BSU15030" /db_xref="EnsemblGenomes-Tr:CAB13376" /db_xref="GOA:O34765" /db_xref="InterPro:IPR011642" /db_xref="InterPro:IPR014226" /db_xref="SubtiList:BG13362" /db_xref="UniProtKB/Swiss-Prot:O34765" /translation="MNLSKINTLLIASFFLFLTATVISHPQASFEASKTGLSMWWEVV FPSLLPFFILSELLIGFGIVRFVGVLLEPFMRPIFRVPGVGGFVLAMGMASGNPAGAK LTARLRQENQISRVEAERLASFTNSSNPLFIFGAVAVGFFQNASLGILLASAHYLGNL AVGLTMRSYGRKEEQHLRRKKTIPFPSVKDALHALHTARLAEKRPLGKILGDAVTSSV QTLLMVGGFIILFSVFNRLLSVVQLTDVLSVFTKGALTLFQLPTQLDIPLLSGMFEIT LGSKLVSETDVSLLQKAIIVSFILGFSGFSVQAQVAGILSETDIRFKPFFIARLLQGV YAAVFVMLLWKPLYTAWHDPYQYVFKSLNSSDMSTAFINGWNLLVQIGPAVTLCALFT YIIIFSYRLTNGTKKG*" /label="spoVV CDS" gene complement(1457550..1458776) /gene="spoVV" /locus_tag="BSU_15030" /old_locus_tag="BSU15030" /label="spoVV gene" S_feature 1457551..1458825 /Source="Nicolas_S_feature" /locus_tag="new_1570575_1571849" /HighExp="H2O2, G135, Paraq, G150, G180, Oxctl, LBGexp, dia0, dia15, Mt0" /AntisenseName="ylbJ" /AntisenseCor="-0.54237424349391605" /AntisenseRegPval="-21.2" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S550" S_feature complement(1458777..1458878) /Source="Nicolas_S_feature" /locus_tag="new_1571801_1571902_c" /HighExp="LoTm, S3, S4, S5, T5.0H, M9-stat, T4.0H, S6, BT, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S551" promotor_-35 1458800..1458807 /Source="Nicolas_upshift_promotors" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1458819..1458838 /Source="Nicolas_upshift_promotors" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1458827..1458956 /Source="Nicolas_S_feature" /locus_tag="new_1571851_1571980" /HighExp="Etha, dia15, dia5, Diami, H2O2, Lbtran, LBGtran, Paraq, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S552" upshifts 1458827 /Source="Nicolas_upshifts" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1458873..1458891) /Source="Nicolas_upshift_promotors" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1458888) /Source="Nicolas_upshifts" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1458908..1458913) /Source="Nicolas_upshift_promotors" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1458957..1459739 /gene="ylbK" /locus_tag="BSU_15040" /old_locus_tag="BSU15040" /EC_number="3.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389387.1" /db_xref="EnsemblGenomes-Gn:BSU15040" /db_xref="EnsemblGenomes-Tr:CAB13377" /db_xref="GOA:O34731" /db_xref="InterPro:IPR001423" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG13363" /db_xref="UniProtKB/Swiss-Prot:O34731" /translation="MAKPKIGLALGSGGARGLAHLGVLSSLHKHQIEVDMIAGSSMGA LVGSFYAAGHDVATMKKVAKAFKRRLYADYTVPKLGFLKGDRVRQLVHAYTFGKPIEE LQIPLGIVACDLQTGEKIVFRKGSVSDAVRASISIPGIFIPQRLDGRLLVDGAVVDRI PVSVVKDMGADIIIASDVSRVRKTETAVHIFDVIMQSMDILQNELVRHQTIAADIMIR PSLETYSSSSFANIEEMISAGEEATNRMISKIRKEIENWEGS*" /label="ylbK CDS" gene 1458957..1459739 /gene="ylbK" /locus_tag="BSU_15040" /old_locus_tag="BSU15040" /label="ylbK gene" promotor_-35 1459519..1459525 /Source="Nicolas_upshift_promotors" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1459539..1459550 /Source="Nicolas_upshift_promotors" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1459550 /Source="Nicolas_upshifts" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="upshifts" CDS 1459741..1460766 /gene="ylbL" /locus_tag="BSU_15050" /old_locus_tag="BSU15050" /function="16.11: Scavenge (Catabolism)" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative degradative enzyme" /protein_id="NP_389388.2" /db_xref="EnsemblGenomes-Gn:BSU15050" /db_xref="EnsemblGenomes-Tr:CAB13378" /db_xref="GOA:O34470" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR036034" /db_xref="PDB:2KJP" /db_xref="SubtiList:BG13364" /db_xref="UniProtKB/Swiss-Prot:O34470" /translation="MLRKKHFSWMLVILILIAVLSFIKLPYYITKPGEATELASLIKV EGGYPEKGSLSLMTVKVGPANPFTYVWAKMHPYYEIVPDESIKEEGESDKEYMKRQLQ MMKSSQENAVIAAYQKAGKKVSYSFNGIYASSVVENMPAKGKIEVGDKIISADGKNYQ SAEKLIDYISSKKAGDKVTLKIEREEKEKRVTLTLKQFPDEPDRAGIGVSLYTDRNVK VEPDIDFEIENIGGPSAGLMMSLEIYNQLTKPDETKGYDIAGTGTIDVDGKVGPIGGI DQKVVAADKAGKDIFFAPNQNGASNSDYKNAVKTAKDIDSNMKIVPVDTMQDAIDYLN KLKAKST*" /label="ylbL CDS" gene 1459741..1460766 /gene="ylbL" /locus_tag="BSU_15050" /old_locus_tag="BSU15050" /label="ylbL gene" downshifts 1460650 /Source="Nicolas_upshifts" /id="D853" /incds=1 /nref=59 /ntot=235 /MaxReadThrough="2.38639" /MaxDrop="3.52503" /score="19.0874959" /energy="-11.5" /TU="NA" /idTUdmin="U1249" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1460783..1462030) /gene="ylbM" /locus_tag="BSU_15060" /old_locus_tag="BSU15060" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 19215769; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative component of the degradosome" /protein_id="NP_389389.1" /db_xref="EnsemblGenomes-Gn:BSU15060" /db_xref="EnsemblGenomes-Tr:CAB13379" /db_xref="InterPro:IPR008513" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13365" /db_xref="UniProtKB/Swiss-Prot:O34513" /translation="MKAVGLVVEYNPFHNGHLYHAQTAKLQTGCDTAVAVMSGHFLQR GEPAVVSKWARTKMALQSGVDLVIELPYLYAVQKADIFARGSVSILNELECEALFFGS ENGDIKPFLETAQLIDEHKHILNDRIKEELKKGASYPAAAAIAFSSILHTESALDLSK PNNILGYQYVTSILTGGYPMKPYTTARISSDYHDADLPEGENHIASATSIRKAMIGQN LEACLRFLPAASARELAAYRKSFGLWHTPESYFSYLKYSLSTVTARELQQVYEVEEGL EHRIIRSIRKSSSYQEFMELLKTKRYTWTRLQRMNTHILTRTKKQDMQKLLDNDKAPY IRLLGMTKKGQAYLSEKKKALSVPLVSKLSSFSHPALDLDVKASRIYSLPIEEPLRTE FDLQEYGHAPIRYDEDEQHFLNV*" /label="ylbM CDS" gene complement(1460783..1462030) /gene="ylbM" /locus_tag="BSU_15060" /old_locus_tag="BSU15060" /label="ylbM gene" downshifts complement(1460810) /Source="Nicolas_upshifts" /id="D854" /incds=0 /nref=8 /ntot=182 /MaxReadThrough="1.58661" /MaxDrop="3.70777" /score="4.49214865" /energy="-11.5" /TU="NA" /idTUdmin="U1257" /TUdmin=775 /isTUend="FALSE" /label="downshifts" promotor_-35 1461947..1461953 /Source="Nicolas_upshift_promotors" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="promotor_-35" promotor_-10 1461967..1461978 /Source="Nicolas_upshift_promotors" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="promotor_-10" upshifts 1461971 /Source="Nicolas_upshifts" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="upshifts" CDS complement(1462027..1462212) /gene="ylzH" /locus_tag="BSU_15069" /old_locus_tag="BSU15069" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein,of unknown function" /protein_id="YP_003097727.1" /db_xref="EnsemblGenomes-Gn:BSU15069" /db_xref="EnsemblGenomes-Tr:CAX52618" /db_xref="UniProtKB/Swiss-Prot:C0H411" /translation="MIIAFKIVFVNIFSLQHNAAIEVSLTAEYAMHTLKTKIRRKSFH LQMYHTFLNIARKAEKI*" /label="ylzH CDS" gene complement(1462027..1462212) /gene="ylzH" /locus_tag="BSU_15069" /old_locus_tag="BSU15069" /label="ylzH gene" promotor_-35 1462045..1462049 /Source="Nicolas_upshift_promotors" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="promotor_-35" promotor_-10 1462065..1462084 /Source="Nicolas_upshift_promotors" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="promotor_-10" S_feature 1462074..1462209 /Source="Nicolas_S_feature" /locus_tag="new_1575098_1575233" /HighExp="Cold, LoTm, Diami, Paraq, H2O2, Oxctl, G180, dia5, G135, LBGexp" /AntisenseName="ylzH" /AntisenseCor="-9.1134498265910996E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S553" upshifts 1462074 /Source="Nicolas_upshifts" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="upshifts" promotor_-10 complement(1462103..1462122) /Source="Nicolas_upshift_promotors" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1462113) /Source="Nicolas_upshifts" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1462136..1462143) /Source="Nicolas_upshift_promotors" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1462180..1462187 /Source="Nicolas_upshift_promotors" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1462201..1462220 /Source="Nicolas_upshift_promotors" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1462211 /Source="Nicolas_upshifts" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="upshifts" CDS 1462240..1462758 /gene="ylbN" /locus_tag="BSU_15070" /old_locus_tag="BSU15070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11700356, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389390.1" /db_xref="EnsemblGenomes-Gn:BSU15070" /db_xref="EnsemblGenomes-Tr:CAB13380" /db_xref="InterPro:IPR003772" /db_xref="SubtiList:BG13366" /db_xref="UniProtKB/Swiss-Prot:O34445" /translation="MKWTIYQLHQMPKQSFEFDETVELNELTKLNSDIRRISPVRVKG RADIKSKQVSFDFTISGEMLLPCSRTLVDVPYPFEISTKELFIFHHTDDIEDDDVHIV EDDTIDITPIVKEEILLEIPMQIFCESEQEKGAAPQEGKDWQVISEEDKKNQVDPRLA ALEKLLKQDDES*" /label="ylbN CDS" gene 1462240..1462758 /gene="ylbN" /locus_tag="BSU_15070" /old_locus_tag="BSU15070" /label="ylbN gene" CDS 1462780..1462959 /gene="rpmF" /locus_tag="BSU_15080" /old_locus_tag="BSU15080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L32" /protein_id="NP_389391.1" /db_xref="EnsemblGenomes-Gn:BSU15080" /db_xref="EnsemblGenomes-Tr:CAB13381" /db_xref="GOA:O34687" /db_xref="InterPro:IPR002677" /db_xref="InterPro:IPR011332" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG12668" /db_xref="UniProtKB/Swiss-Prot:O34687" /translation="MAVPFRRTSKMKKRLRRTHFKLNVPGMTECPSCGEMKLSHRVCK ACGSYNGKDINVKSN*" /label="rpmF CDS" gene 1462780..1462959 /gene="rpmF" /locus_tag="BSU_15080" /old_locus_tag="BSU15080" /label="rpmF gene" downshifts 1462939 /Source="Nicolas_upshifts" /id="D855" /incds=0 /nref=232 /ntot=266 /MaxReadThrough="5.64002" /MaxDrop="7.70407" /score="53.0065581" /energy="-17.1" /TU="U1258" /idTUdmin="U1256" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1462982) /Source="Nicolas_upshifts" /id="U1259" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.946053946053946" /psig=0 /xcortree=65 /SigmaFactorBS="actatttgcactcacaaattttccgcaagctgacaggaagag aaaaagaaaaaGCGCagggctttcaccctgcgcttttctcattagttactttttacat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1462986..1462989) /Source="Nicolas_upshift_promotors" /id="U1259" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.946053946053946" /psig=0 /xcortree=65 /SigmaFactorBS="actatttgcactcacaaattttccgcaagctgacaggaagag aaaaagaaaaaGCGCagggctttcaccctgcgcttttctcattagttactttttacat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1463040..1463045 /Source="Nicolas_upshift_promotors" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1463061..1463079 /Source="Nicolas_upshift_promotors" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1463062 /Source="Nicolas_upshifts" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="upshifts" CDS 1463105..1463686 /gene="gerR" /locus_tag="BSU_15090" /old_locus_tag="BSU15090" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15621419, 20435725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15621419, 20435725; Product type r: regulator" /codon_start=1 /transl_table=11 /product="DNA-binding regulator" /protein_id="NP_389392.1" /db_xref="EnsemblGenomes-Gn:BSU15090" /db_xref="EnsemblGenomes-Tr:CAB13382" /db_xref="GOA:O34549" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014243" /db_xref="InterPro:IPR017930" /db_xref="SubtiList:BG13367" /db_xref="UniProtKB/Swiss-Prot:O34549" /translation="MTITRQDAWTQDEDLLLAEVVLRHIREGGTQLSAFEEVGRALTR TAAACGFRWNSYVRKQYQSGIELAKKQRKELRKQIGVHSVNMPNSMKQTASASSEGKR DLSIQDVIQFLEQFKETPSAQEFQLEREKLKEQIQSLQKELEDLRSENQTLRNQLEMT EEDYKALIDIMDRARKMVVSKEDGRMKKAAQET*" /label="gerR CDS" gene 1463105..1463686 /gene="gerR" /locus_tag="BSU_15090" /old_locus_tag="BSU15090" /label="gerR gene" downshifts 1463687 /Source="Nicolas_upshifts" /id="D856" /incds=0 /nref=56 /ntot=139 /MaxReadThrough="2.70626" /MaxDrop="5.6861" /score="-7.71867756" /energy="-12.8" /TU="U1260" /idTUdmin="U1258" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1463743..1464225) /gene="ylbP" /locus_tag="BSU_15100" /old_locus_tag="BSU15100" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389393.2" /db_xref="EnsemblGenomes-Gn:BSU15100" /db_xref="EnsemblGenomes-Tr:CAB13383" /db_xref="GOA:O34468" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR017274" /db_xref="PDB:2PR1" /db_xref="SubtiList:BG13368" /db_xref="UniProtKB/Swiss-Prot:O34468" /translation="MTKVERLLINYKTLEEFKKFKEYGIQELSMLEELQDNIIENDST SPFYGIYFGDKLVARMSLYQVNGKSNPYFDNRQDYLELWKLEVLPGYQNRGYGRALVE FAKSFKMPIRTNPRMKSAEFWNKMNFKTVKYDMARDKGENPLIWHPDMDREMTPGESA *" /label="ylbP CDS" gene complement(1463743..1464225) /gene="ylbP" /locus_tag="BSU_15100" /old_locus_tag="BSU15100" /label="ylbP gene" downshifts complement(1463762) /Source="Nicolas_upshifts" /id="D857" /incds=0 /nref=90 /ntot=231 /MaxReadThrough="3.90092" /MaxDrop="6.59996" /score="14.5482917" /energy="-14.5" /TU="U1261" /idTUdmin="U1261" /TUdmin="-615" /isTUend="FALSE" /label="downshifts" downshifts 1464215 /Source="Nicolas_upshifts" /id="D858" /incds=0 /nref=1 /ntot=24 /MaxReadThrough="3.3013" /MaxDrop="4.42908" /score="-7.71867756" /energy="-12.8" /TU="NA" /idTUdmin="U1260" /TUdmin=418 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1464248..1464267) /Source="Nicolas_upshift_promotors" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1464267) /Source="Nicolas_upshifts" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1464281..1464288) /Source="Nicolas_upshift_promotors" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1464325..1464331 /Source="Nicolas_upshift_promotors" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="promotor_-35" promotor_-10 1464343..1464362 /Source="Nicolas_upshift_promotors" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="promotor_-10" upshifts 1464345 /Source="Nicolas_upshifts" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="upshifts" CDS 1464385..1465281 /gene="panE" /locus_tag="BSU_15110" /old_locus_tag="BSU15110" /EC_number="1.1.1.169" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1844812, 10736170, 23894131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1844812, 10736170, 23894131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-dehydropantoate 2-reductase" /protein_id="NP_389394.1" /db_xref="EnsemblGenomes-Gn:BSU15110" /db_xref="EnsemblGenomes-Tr:CAB13384" /db_xref="GOA:O34661" /db_xref="InterPro:IPR003710" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR013332" /db_xref="InterPro:IPR013752" /db_xref="InterPro:IPR036291" /db_xref="PDB:3EGO" /db_xref="SubtiList:BG13369" /db_xref="UniProtKB/Swiss-Prot:O34661" /translation="MKIGIIGGGSVGLLCAYYLSLYHDVTVVTRRQEQAAAIQSEGIR LYKGGEEFRADCSADTSINSDFDLLVVTVKQHQLQSVFSSLERIGKTNILFLQNGMGH IHDLKDWHVGHSIYVGIVEHGAVRKSDTAVDHTGLGAIKWSAFDDAEPDRLNILFQHN HSDFPIYYETDWYRLLTGKLIVNACINPLTALLQVKNGELLTTPAYLAFMKLVFQEAC RILKLENEEKAWERVQAVCGQTKENRSSMLVDVIGGRQTEADAIIGYLLKEASLQGLD AVHLEFLYGSIKALERNTNKVF*" /label="panE CDS" gene 1464385..1465281 /gene="panE" /locus_tag="BSU_15110" /old_locus_tag="BSU15110" /label="panE gene" CDS 1465352..1466971 /gene="bshC" /locus_tag="BSU_15120" /old_locus_tag="BSU15120" /EC_number="6.-.-.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16169927, 19578333, 20308541, 20799687, 25496067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16169927, 19578333, 20308541, 20799687, 25496067; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate glucosamine cysteine ligase" /protein_id="NP_389395.2" /db_xref="EnsemblGenomes-Gn:BSU15120" /db_xref="EnsemblGenomes-Tr:CAB13385" /db_xref="GOA:P55342" /db_xref="InterPro:IPR011199" /db_xref="PDB:4WBD" /db_xref="SubtiList:BG11424" /db_xref="UniProtKB/Swiss-Prot:P55342" /translation="MQLTELSIKNQNVFVQHYIDGKEEMSSFFDYSIHHKDMWRERLE DLSSRFFAREELAAYLTSYHNKFGSSAMQSAIEKLKDPSSAAVVGGQQAGLLTGPLYT IHKIISIIVLAKQQEKELQVPVIPIFWVAGEDHDLDEINFVHTSEENGPVKKKLPQSY WKKSSAASTSLDQEKCAAWIDDVFAAFEETDHTNTLLDNVKRCLRESVTFTDFFELLI ADLFQEEGLVLLNSGDPGIKKLETAMFQKILRENDELARAVSDQQAFMRQAGYKPIIE SGKEQANLFYEYEDERFLIEKDNGRFVIKELDLGWTRDELHTHMEEHPERFSNNVVTR PLMQEFLIPTLAFIAGPGEINYWGELKQAFAVMGFKMPPVMPRLNITILERHIEKKLA ERNISLQDAIERGTENQRETYFERQIPEEFTAVMDQAKSQIEAIHKTVRQEALKVDQS LEPLLLKNAAFIQDQLQFLERTVMKRIEEKEGYVLKDYERIQNSIKPLLAPQERIWNI MYYLNRYGPKFFTTFKNLPFSFQNQHQVVKL*" /label="bshC CDS" gene 1465352..1466971 /gene="bshC" /locus_tag="BSU_15120" /old_locus_tag="BSU15120" /label="bshC gene" downshifts 1466943 /Source="Nicolas_upshifts" /id="D859" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="3.87099" /MaxDrop="3.76832" /score="34.9463932" /energy="-8.3" /TU="U1262" /idTUdmin="U1262" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-35 1467005..1467008 /Source="Nicolas_upshift_promotors" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1467023..1467096 /Source="Nicolas_S_feature" /locus_tag="new_1580047_1580120" /HighExp="M9-stat, T5.0H, T3.0H, Lbstat, Lbtran, T2.30H, T1.30H, M0t90, T1.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.955" /TUlongSig="SigA" /TUlongPSig=1 /label="S554" promotor_-10 1467023..1467042 /Source="Nicolas_upshift_promotors" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1467023 /Source="Nicolas_upshifts" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1467080) /Source="Nicolas_upshifts" /id="D860" /incds=0 /nref=17 /ntot=137 /MaxReadThrough="3.30554" /MaxDrop="4.47473" /score="-9.92306593" /energy="-12" /TU="NA" /idTUdmin="U1264" /TUdmin=1149 /isTUend="FALSE" /label="downshifts" CDS 1467097..1467528 /gene="mraZ" /locus_tag="BSU_15130" /old_locus_tag="BSU15130" /function="16.13: Shape" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10572301, 15939023, 16511046, 24659771, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of RsmH and transcriptional regulator" /protein_id="NP_389396.1" /db_xref="EnsemblGenomes-Gn:BSU15130" /db_xref="EnsemblGenomes-Tr:CAB13386" /db_xref="GOA:P55343" /db_xref="InterPro:IPR003444" /db_xref="InterPro:IPR007159" /db_xref="InterPro:IPR020603" /db_xref="InterPro:IPR035642" /db_xref="InterPro:IPR035644" /db_xref="SubtiList:BG11425" /db_xref="UniProtKB/Swiss-Prot:P55343" /translation="MFMGEYQHTIDAKGRMIVPAKFREGLGEQFVLTRGLDQCLFGYP MHEWKQIEEKLKALPLTKKDARAFTRFFFSGATECELDKQGRVNIASSLLNYAKLEKE CVVIGVSNRIELWSKVIWEQYTEEQEDSFAEIAENMIGFDI*" /label="mraZ CDS" gene 1467097..1467528 /gene="mraZ" /locus_tag="BSU_15130" /old_locus_tag="BSU15130" /label="mraZ gene" CDS 1467598..1468533 /gene="rsmH" /locus_tag="BSU_15140" /old_locus_tag="BSU15140" /EC_number="2.1.1.199" /function="16.6: Maintain" /function="16.13: Shape" /function="16.9: Replicate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9294438, 9721276, 10572301, 16849811, 19965768, 20924196, 22561317, 27711192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA m4C1402 methyltransferase" /protein_id="NP_389397.1" /db_xref="EnsemblGenomes-Gn:BSU15140" /db_xref="EnsemblGenomes-Tr:CAB13387" /db_xref="GOA:Q07876" /db_xref="InterPro:IPR002903" /db_xref="InterPro:IPR023397" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10219" /db_xref="UniProtKB/Swiss-Prot:Q07876" /translation="MFQHKTVLLRETVDGLNIKPDGTYVDCTLGGAGHSTYLLQQLSE KGRLIAFDQDDTALQHAKEVLSDYKGQLILIKSNFRYLKEYLNEQGVTEVDGILFDLG VSSPQLDTPERGFSYHHDAPLDMRMDQSATLSAKEVVNEWRYEDLVRIFFKYGEEKFS KQIARKIEEARMKSPIQTTGQLVDLIKDAIPAPARRSGGHPAKRVFQAIRIAVNDELR VFEEALEQAIEVLKPGGRVSVITFHSLEDRICKTTFKEKSSLPELPPGLPVIPEEFEP ELKLITRKPITASQEELEENNRARSAKLRIAEKRK*" /label="rsmH CDS" gene 1467598..1468533 /gene="rsmH" /locus_tag="BSU_15140" /old_locus_tag="BSU15140" /label="rsmH gene" S_feature complement(1468200..1469652) /Source="Nicolas_S_feature" /locus_tag="new_1581224_1582676_c" /HighExp="Salt, Sw, B60, Etha, M9-stat, Gly, C30, LPhT, BC, B36" /AntisenseName="ftsL" /AntisenseCor="-0.195961042435877" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S555" CDS 1468573..1468926 /gene="ftsL" /locus_tag="BSU_15150" /old_locus_tag="BSU15150" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10792716, 10844672, 11994149, 16549676, 16936019, 17020588, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10792716, 10844672, 11994149, 16549676, 16936019, 17020588, 22720735; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division protein" /protein_id="NP_389398.1" /db_xref="EnsemblGenomes-Gn:BSU15150" /db_xref="EnsemblGenomes-Tr:CAB13388" /db_xref="GOA:Q07867" /db_xref="InterPro:IPR011922" /db_xref="SubtiList:BG10220" /db_xref="UniProtKB/Swiss-Prot:Q07867" /translation="MSNLAYQPEKQQRHAISPEKKVIVKKRASITLGEKVLLVLFAAA VLSVSLLIVSKAYAAYQTNIEVQKLEEQISSENKQIGDLEKSVADLSKPQRIMDIAKK NGLNLKDKKVKNIQE*" /label="ftsL CDS" gene 1468573..1468926 /gene="ftsL" /locus_tag="BSU_15150" /old_locus_tag="BSU15150" /label="ftsL gene" CDS 1468923..1471073 /gene="pbpB" /locus_tag="BSU_15160" /old_locus_tag="BSU15160" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8636036, 10411726, 12682299, 14731276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8636036, 10411726, 12682299, 14731276; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 2B" /protein_id="NP_389399.2" /db_xref="EnsemblGenomes-Gn:BSU15160" /db_xref="EnsemblGenomes-Tr:CAB13389" /db_xref="GOA:Q07868" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG10221" /db_xref="UniProtKB/Swiss-Prot:Q07868" /translation="MIQMPKKNKFMNRGAAILSICFALFFFVILGRMAYIQITGKANG EVLATKATEQHEKKRTIEASRGSILDRKGKVIAEDTATYKLIAILDKKMTTDVKHPQH VVNKEKTAEALSKVINLDKADILDILNKDAKQVEFGSAGRDITYSQKQKIEKMKLPGI SFLRDTKRYYPNGVFASNLIGYAEVDEETNEISGAMGLEKVLDKYLKERDGYVTYESD KSGWELPNSKNKITAPKNGDNVYLTIDQKIQTFLEDSMTKVAQKYNPKKIMAAVVDPK TGKVLAMGQRPSFDPNKRDVTNYYNDLISYAYEPGSTMKIFTLAAAMQENVFNANEKY KSGTFEVGGAPVKDHNNGVGWGPTTYHDGVLRSSNVAFAKLAKEKLGYDRLNQYLHKF NFYQKTGIDLPGEVSSKINFKYEFDKASTAYGQASAVTPIQQIQAATAIANDGKMMKP YVIDHIVDPDKDKTIYQNKPESAGTPISASTAKKVRDILGEVVTSKIGTGQAYKIEGF DVAGKTGTAQIAGKGGYLDGTDNYIFSFMGMAPKDDPELLIYVAVQQPQLKAGQSSSD PVSEIFNPTMKNSLHYLNIEPTEKSDSDKEETKAQTMPDLTDQTVAAAQKKAKEENLT PIVIGSDVAVKEQYPKADEEVLTNQKVFLKTGGKIKMPDMTGWSRREVLQYGELAGIH IEVSGQGYAVSQSVKKDKEIKDKTVIKVKFKNPD*" /label="pbpB CDS" gene 1468923..1471073 /gene="pbpB" /locus_tag="BSU_15160" /old_locus_tag="BSU15160" /label="pbpB gene" promotor_-10 complement(1469633..1469651) /Source="Nicolas_upshift_promotors" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1469652) /Source="Nicolas_upshifts" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1469666..1469672) /Source="Nicolas_upshift_promotors" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1471056 /Source="Nicolas_upshifts" /id="D861" /incds=0 /nref=237 /ntot=257 /MaxReadThrough="1.141" /MaxDrop="6.28059" /score="3.41058446" /energy="-7.4" /TU="NA" /idTUdmin="U1263" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 1471128..1471133 /Source="Nicolas_upshift_promotors" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="promotor_-35" promotor_-10 1471149..1471167 /Source="Nicolas_upshift_promotors" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="promotor_-10" upshifts 1471149 /Source="Nicolas_upshifts" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="upshifts" CDS 1471190..1473130 /gene="spoVD" /locus_tag="BSU_15170" /old_locus_tag="BSU15170" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8244929, 8289242, 9006059, 28383125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8244929, 8289242, 9006059, 28383125; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="transpeptidase penicillin-binding protein" /protein_id="NP_389400.2" /db_xref="EnsemblGenomes-Gn:BSU15170" /db_xref="EnsemblGenomes-Tr:CAB13390" /db_xref="GOA:Q03524" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR011927" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG10222" /db_xref="UniProtKB/Swiss-Prot:Q03524" /translation="MRVSNVTVRKRLLFVLLFGVIVFLIIDTRLGYVQFVMGEKLTSL AKDSWSRNLPFEPERGEILDRNGVKLATNKSAPTVFVVPRQVQNPMKTSKQLAAVLNM SEEKVYKHVTKKASIEKITPEGRKISNEKAKEIKALDLKGVYVAEDSIRHYPFGSFLS HVLGFAGIDNQGLLGLEAYYDDDLKGEKGSVKFYTDAKGKKMPDEADDYTPPKDGLDM KLTVDSKVQTIMERELDNAEAKYHPDGMIAVAMNPKNGEILGMSSRPDFDPADYQSVD PSVYNRNLPVWSTYEPGSTFKIITLAAALEEQKVNLKRDQFYDKGHAEVDGARLRCWK RGGHGLQTYLEVVQNSCNPGFVELGERLGKEKLFKYIKDFGFGQKTGIDLQGEGTGIL FPLERVGPVEQATTAFGQGVSVTPIQQVAAVSAAVNGGTLYTPYIAKEWIDPVTKKTV KKQSPIAKKQVISEETSKQIRYALESVVAEGTGRNAFVEGYRVGGKTGTAQKVKDGKY LENNHIVSFIGFAPADDPSLVVYVAVDNPKGTIQFGGTVAAPIVGNIMRDSLPELGVK PRKNQIEKKYQWNDTKTIEVPNVVGMSVSDLESLLVNLNVDASGKGSKIVKQSPAAGT KVKEGSKIRVYLTEEDEKEAAD*" /label="spoVD CDS" gene 1471190..1473130 /gene="spoVD" /locus_tag="BSU_15170" /old_locus_tag="BSU15170" /label="spoVD gene" promotor_-35 1472926..1472932 /Source="Nicolas_upshift_promotors" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="promotor_-35" promotor_-10 1472947..1472955 /Source="Nicolas_upshift_promotors" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="promotor_-10" upshifts 1472953 /Source="Nicolas_upshifts" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="upshifts" downshifts 1473103 /Source="Nicolas_upshifts" /id="D862" /incds=0 /nref=19 /ntot=91 /MaxReadThrough="4.23549" /MaxDrop="4.37308" /score="-3.90592085" /energy="-13.6" /TU="U1265,U1266" /idTUdmin="U1265" /TUdmin="-91" /isTUend="FALSE" /label="downshifts" S_feature 1473148..1473215 /Source="Nicolas_S_feature" /locus_tag="new_1586172_1586239" /HighExp="C30, G180, G135, ferm, MG 15, G150, MG 45, MG-0.1, MG 10, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S556" promotor_-35 1473185..1473189 /Source="Nicolas_upshift_promotors" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1473205..1473224 /Source="Nicolas_upshift_promotors" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" S_feature 1473217..1473305 /Source="Nicolas_S_feature" /locus_tag="new_1586241_1586329" /HighExp="G180, G150, LBGexp, Paraq, G135, Oxctl, C30, dia0, Cold, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S557" upshifts 1473217 /Source="Nicolas_upshifts" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="upshifts" CDS 1473306..1474790 /gene="murE" /locus_tag="BSU_15180" /old_locus_tag="BSU15180" /EC_number="6.3.2.13" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8436954, 10520745, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamate-2, 6-diaminopimelate ligase" /protein_id="NP_389401.1" /db_xref="EnsemblGenomes-Gn:BSU15180" /db_xref="EnsemblGenomes-Tr:CAB13391" /db_xref="GOA:Q03523" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005761" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR035911" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10223" /db_xref="UniProtKB/Swiss-Prot:Q03523" /translation="MKLTKLLTYLTTEPSVNDSQDPEITSIEMDSREVKKGSLFVCVK GYTVDGHDFAQKAVENGAAAIVAEREVDVNVPVIIVRQSLRALSVLSDAFYGQPTKKL QLIGITGTNGKTSTTHMVDEILKKAGKRTGLIGTMYMKIGDETLPVKNTTPESVTLQK TFKKMNDKHVDTAIMEVSSHALSLGRVHGCDYDIAVFTNLTQDHLDYHKTMDEYRHAK SLLFSQLGGAFNHEHPKRAVLNADDEASAYFEKVTAAHISTYGIKNDADVMAKNISIT AQGTSFDLVTNKGTKHITMSLVGQFNVYNVLAAVATCIAAGIPFEIITEAVEELHGVR GRFELVNQQQEFPVIVDYAHTPDSLENVLETCRDMTEGKLFVVVGCGGDRDKTKRPKM AKIAVELADEPIFTSDNPRSEDPRAILRDMEAGVENAYYHSIANREQAIFFAIANAKK GDVVLIAGKGHETYQQIGNETFDFDDAEVAARAIVELNKNKTNS*" /label="murE CDS" gene 1473306..1474790 /gene="murE" /locus_tag="BSU_15180" /old_locus_tag="BSU15180" /label="murE gene" S_feature 1474791..1474901 /Source="Nicolas_S_feature" /locus_tag="new_1587815_1587925" /HighExp="G180, G135, G150, C30, Oxctl, dia0, LBGexp, MG 25, Paraq, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S558" CDS 1474902..1475876 /gene="mraY" /locus_tag="BSU_15190" /old_locus_tag="BSU15190" /EC_number="2.7.8.13" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15131133, 15849754, 16850406, 9592129, 24895118, 26620564, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15131133, 15849754, 16850406, 9592129, 24895118, 26620564, 27312048; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phospho-N-acetylmuramoyl-pentapeptide undecaprenyl phosphate (C55P) transferase" /protein_id="NP_389402.2" /db_xref="EnsemblGenomes-Gn:BSU15190" /db_xref="EnsemblGenomes-Tr:CAB13392" /db_xref="GOA:Q03521" /db_xref="InterPro:IPR000715" /db_xref="InterPro:IPR003524" /db_xref="InterPro:IPR018480" /db_xref="SubtiList:BG10224" /db_xref="UniProtKB/Swiss-Prot:Q03521" /translation="MLEQVILFTILMGFLISVLLSPILIPFLRRLKFGQSIREEGPKS HQKKSGTPTMGGVMIILSIIVTTIVMTQKFSEISPEMVLLLFVTLGYGLLGFLDDYIK VVMKRNLGLTSKQKLIGQIIIAVVFYAVYHYYNFATDIRIPGTDLSFDLGWAYFILVL FMLVGGSNAVNLTDGLDGLLSGTAAIAFGAFAILAWNQSQYDVAIFSVAVVGAVLGFL VFNAHPAKVFMGDTGSLALGGAIVTIAILTKLEILLVIIGGVFVIETLSVILQVISFK TTGKRIFKMSPLHHHYELVGWSEWRVVVTFWAAGLLLAVLGIYIEVWL*" /label="mraY CDS" gene 1474902..1475876 /gene="mraY" /locus_tag="BSU_15190" /old_locus_tag="BSU15190" /label="mraY gene" CDS 1475877..1477232 /gene="murD" /locus_tag="BSU_15200" /old_locus_tag="BSU15200" /EC_number="6.3.2.9" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1765076, 9218784, 10966819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamate ligase" /protein_id="NP_389403.1" /db_xref="EnsemblGenomes-Gn:BSU15200" /db_xref="EnsemblGenomes-Tr:CAB13393" /db_xref="GOA:Q03522" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005762" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10225" /db_xref="UniProtKB/Swiss-Prot:Q03522" /translation="MENDQFLQKQHFLILGLAKSGYAAASILHEKGIYVAVNDQKPFE ENEPAQKLSEKGIEVVCGEHPVSLFDQHQITILIKNPGIPYENIMVQEAEKRGIPVWT EIELAYYLTSAKFIGITGSNGKTTTTTLIYEMLKADSQKALIAGNIGTVASEVAYHAD GDEWIVTELSSFQLMGTHAFRPEISLILNVFDAHLDYHHTRENYEKAKQKVYLHQTAS DKAIVNQDDETVVRLAEAGKAEIVPFSVSKTLEQGAYVKDSMIMFNGEAILPLEEVVL PGAHNLENILAAIAVVKTAGASNEAVKKVLTSFTGVKHRLQYVTTVNGRKFYNDSKAT NILATSKALSAFDKPVILLAGGLDRGNGFDDLKPYMKHVKAVLTFGQTAPKLEKLGNE LGIQHVKRVDNVEQAVSAAFALSNEGDVILLSPACASWDQFKTFEERGDMFIDAVHML K*" /label="murD CDS" gene 1475877..1477232 /gene="murD" /locus_tag="BSU_15200" /old_locus_tag="BSU15200" /label="murD gene" promotor_-35 1477056..1477061 /Source="Nicolas_upshift_promotors" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="promotor_-35" promotor_-10 1477077..1477095 /Source="Nicolas_upshift_promotors" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="promotor_-10" upshifts 1477087 /Source="Nicolas_upshifts" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="upshifts" CDS 1477293..1478393 /gene="spoVE" /locus_tag="BSU_15210" /old_locus_tag="BSU15210" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:2509435, 9622350, 15849754, 16484183, 16850406, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2509435, 9622350, 15849754, 16484183, 16850406, 27312048; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="factor for spore cortex peptidoglycan synthesis (stage V sporulation)" /protein_id="NP_389404.1" /db_xref="EnsemblGenomes-Gn:BSU15210" /db_xref="EnsemblGenomes-Tr:CAB13394" /db_xref="GOA:P07373" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR013437" /db_xref="InterPro:IPR013438" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG10226" /db_xref="UniProtKB/Swiss-Prot:P07373" /translation="MTTKKTSPDLLLVIITLLLLTIGLIMVYSASAVWADYKFDDSFF FAKRQLLFAGIGVIAMFFIMNVDYWTWRTWSKLLMVICFFLLVLVLIPGVGMVRNGSR SWIGVGAFSIQPSEFMKLAMIAFLAKFLSEKQKNITSFRRGFVPALGIVFSAFLIIMC QPDLGTGTVMVGTCIVMIFVAGARIAHFVFLGLIGLSGFVGLVLSAPYRIKRITSYLN PWEDPLGSGFQIIQSLYAVGPGGLFGMGLGQSRQKFFYLPEPQTDFIFAILSEELGFI GGTLILLLFSVLLWRGIRIALGAPDLYGSFVAVGIISMIAIQVMINIGVVTGLIPVTG ITLPFLSYGGSSLTLMLMAVGVLLNVSRYSRY*" /label="spoVE CDS" gene 1477293..1478393 /gene="spoVE" /locus_tag="BSU_15210" /old_locus_tag="BSU15210" /label="spoVE gene" S_feature 1478394..1478515 /Source="Nicolas_S_feature" /locus_tag="new_1591418_1591539" /HighExp="G180, C30, G135, G150, Oxctl, Paraq, LBGexp, dia0, S3, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, Sig-" /TUshortPSig="0.569, 1, 0.436" /TUlongSig="NA" /TUlongPSig="NA" /label="S559" CDS 1478516..1479607 /gene="murG" /locus_tag="BSU_15220" /old_locus_tag="BSU15220" /EC_number="2.4.1.227" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9244290, 11042447, 12538870, 12682299, 12813070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9244290, 11042447, 12538870, 12682299, 12813070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine-N-acetylmuramyl- (pentapeptide)pyrophosphoryl-undecaprenol N-acetylglucosamine transferase" /protein_id="NP_389405.2" /db_xref="EnsemblGenomes-Gn:BSU15220" /db_xref="EnsemblGenomes-Tr:CAB13395" /db_xref="GOA:P37585" /db_xref="InterPro:IPR004276" /db_xref="InterPro:IPR006009" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG10227" /db_xref="UniProtKB/Swiss-Prot:P37585" /translation="MRIAISGGGTGGHIYPALAFIKEVQRRHPNVEFLYIGTENGLEK KIVERENIPFRSIEITGFKRKLSFENVKTVMRFLKGVKKSKSYLAEFKPDAVIGTGGY VCGPVVYAAAKMGIPTIVHEQNSLPGITNKFLSKYVNKVAICFEEAKSHFPSEKVVFT GNPRASEVVSIKTGRSLAEFGLSEDKKTVLIFGGSRGAAPINRAVIDMQDVLKTRDYQ VLYITGEVHYEKVMNELKSKGAADNMVTKPFLHQMPEYLKAIDVIVARAGATTIAEIT ALGIPSVLIPSPYVTANHQEVNARSLGQHDAAIVLKETELSGEKLIEALDRIVLNEQT LKEMSERTKSLGVPDAAARLYSVLEELKK*" /label="murG CDS" gene 1478516..1479607 /gene="murG" /locus_tag="BSU_15220" /old_locus_tag="BSU15220" /label="murG gene" promotor_-35 1478996..1479005 /Source="Nicolas_upshift_promotors" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1479018..1479033 /Source="Nicolas_upshift_promotors" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" upshifts 1479023 /Source="Nicolas_upshifts" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="upshifts" promotor_no_box 1479029..1479129 /Source="Nicolas_upshift_promotors" /id="U1270" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.363636363636364" /psig="0.0739260739260739" /xcortree=271 /SigmaFactorBS="aagacgggacgatcattggctgaatttgggctttctgaagac aaaaaaacggtcttaattttcggcggaagccgaggcgctgcaccgattaaccgcgctg t" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1479089 /Source="Nicolas_upshifts" /id="U1270" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.363636363636364" /psig="0.0739260739260739" /xcortree=271 /SigmaFactorBS="aagacgggacgatcattggctgaatttgggctttctgaagac aaaaaaacggtcttaattttcggcggaagccgaggcgctgcaccgattaaccgcgctg t" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /GFF_Attribute="listLong" /label="upshifts" CDS 1479639..1480550 /gene="murB" /locus_tag="BSU_15230" /old_locus_tag="BSU15230" /EC_number="1.3.1.98" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11327854, 12682299, 16484183, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylenolpyruvoylglucosamine reductase" /protein_id="NP_389406.1" /db_xref="EnsemblGenomes-Gn:BSU15230" /db_xref="EnsemblGenomes-Tr:CAB13396" /db_xref="GOA:P18579" /db_xref="InterPro:IPR003170" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR011601" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="InterPro:IPR036635" /db_xref="SubtiList:BG10228" /db_xref="UniProtKB/Swiss-Prot:P18579" /translation="MEKVIQELKEREVGKVLANEPLANHTTMKIGGPADVLVIPSSVD AVKDIMDVIKKYDVKWTVIGRGSNLLVLDEGIRGVVIKLGAGLDHLELEGEQVTVGGG YSVVRLATSLSKKGLSGLEFAAGIPGSVGGAVYMNAGAHGSDMSEILVKAHILFEDGT IEWLTNEQMDFSYRTSVLQKKRPGVCLEAVLQLEQKDKESIVQQMQSNKDYRKNTQPY SSPCAGSIFRNPLPNHAGNLVEKAGLKGYQIGGAKISEMHGNFIVNAGGASAKDVLDL IDHVKKTIREKYEIDMHTEVEIIGGNR*" /label="murB CDS" gene 1479639..1480550 /gene="murB" /locus_tag="BSU_15230" /old_locus_tag="BSU15230" /label="murB gene" downshifts 1480568 /Source="Nicolas_upshifts" /id="D863" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="5.78428" /MaxDrop="2.8642" /score="-7.67573434" /energy="-7.4" /TU="U1267,U1268,U1269,U1270" /idTUdmin="U1266" /TUdmin=1809 /isTUend="FALSE" /label="downshifts" CDS 1480680..1481471 /gene="divIB" /locus_tag="BSU_15240" /old_locus_tag="BSU15240" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10852898, 12682299, 15659156, 16618922, 16936019, 16936026, 20460179, 20870765" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10852898, 12682299, 15659156, 16618922, 16936019, 16936026, 20460179, 20870765; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389407.1" /db_xref="EnsemblGenomes-Gn:BSU15240" /db_xref="EnsemblGenomes-Tr:CAB13397" /db_xref="GOA:P16655" /db_xref="InterPro:IPR005548" /db_xref="InterPro:IPR013685" /db_xref="InterPro:IPR026580" /db_xref="InterPro:IPR034746" /db_xref="SubtiList:BG10229" /db_xref="UniProtKB/Swiss-Prot:P16655" /translation="MNPGQDREKIVNIEERIPKIKEQRKQKANRRLISFIMLFFIMVL IIVYLQTPISKVSTISVTGNENVSKKEIIDLSDINSGDTEFWSLDKQKTEKKIQQNKL VKKAEISKSLPNKINIAIEEYKAIAYLEKDDVYYEVLENGSVLPNEVTPDDAGPILVN WTNAKKRSQMAKQLDALSNSLKQSISEIYYTPVKMDENRIKLYMNDGYVVTASIKTFA DRMKTYPSIISQLSSNKKGIIHLEVATYFEEFGKNDKAAKKEDEN*" /label="divIB CDS" gene 1480680..1481471 /gene="divIB" /locus_tag="BSU_15240" /old_locus_tag="BSU15240" /label="divIB gene" CDS 1481468..1482163 /gene="ylxW" /locus_tag="BSU_15250" /old_locus_tag="BSU15250" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16484183" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389408.2" /db_xref="EnsemblGenomes-Gn:BSU15250" /db_xref="EnsemblGenomes-Tr:CAB13398" /db_xref="GOA:C0SPA3" /db_xref="InterPro:IPR010273" /db_xref="SubtiList:BG11490" /db_xref="UniProtKB/Swiss-Prot:C0SPA3" /translation="MRGKSAVLLSLIMLIAGFLISFSFQMTKENNKSAAETEEWKKEY ALRDELLKQEKENKKFEKELYQKQNKVRQAENKLKKEKSEYYNVLEDTEKYRMYIGEV GVQGEGVEVTLEDASYIPEGENVNSYIVHESHIFQVVNELYISGAAAVAVNGQRLTHD SYIKCNGPVVTVDGVQHPAPFTVSAIGDPDVLLPSLNIAGGLIDQLSMDHISVSAEKE KNVQMKPILKTKE*" /label="ylxW CDS" gene 1481468..1482163 /gene="ylxW" /locus_tag="BSU_15250" /old_locus_tag="BSU15250" /label="ylxW gene" CDS 1482186..1482893 /gene="ylxX" /locus_tag="BSU_15260" /old_locus_tag="BSU15260" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16484183, 18179421" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389409.2" /db_xref="EnsemblGenomes-Gn:BSU15260" /db_xref="EnsemblGenomes-Tr:CAB13399" /db_xref="GOA:Q45544" /db_xref="InterPro:IPR010273" /db_xref="SubtiList:BG11489" /db_xref="UniProtKB/Swiss-Prot:Q45544" /translation="MKIKRSFISISVLMVIFGLMISVQFNSLKHPKVRDTRDMWDIRE ELTSEQKKQEKLLAEINKYDKLLNSYSQTKEMTKETALNNTLQSLKKTAGMTDITGSG IVITISPLFSESLTGEPIENPPPDLLKKLINELNSYGAEHISINERRVVNHTVIRDIN GTTKIDGYALDDYPLTVKVLAKDPDMLHSRVKGSGLEDLFASENLALKAGKSESKLTL KAYDRPLDVQQLKLLKD*" /label="ylxX CDS" gene 1482186..1482893 /gene="ylxX" /locus_tag="BSU_15260" /old_locus_tag="BSU15260" /label="ylxX gene" CDS 1482911..1483276 /gene="sbp" /locus_tag="BSU_15270" /old_locus_tag="BSU15270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1569582, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein (small basic protein)" /protein_id="NP_389410.1" /db_xref="EnsemblGenomes-Gn:BSU15270" /db_xref="EnsemblGenomes-Tr:CAB13400" /db_xref="GOA:P28265" /db_xref="InterPro:IPR009709" /db_xref="SubtiList:BG10230" /db_xref="UniProtKB/Swiss-Prot:P28265" /translation="MWLPVLGLVLGIAIGLMTNLTIPSEYSNYLSLAVLAALDTLIGG IRAHLQGTYDEMVFVSGFFFNIILAISLAFLGVHLGVDLYLAGIFAFGVRLFQNIAVI RRNLLTKWTLSKKNKKNVI*" /label="sbp CDS" gene 1482911..1483276 /gene="sbp" /locus_tag="BSU_15270" /old_locus_tag="BSU15270" /label="sbp gene" promotor_-35 1483128..1483131 /Source="Nicolas_upshift_promotors" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1483147..1483166 /Source="Nicolas_upshift_promotors" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" upshifts 1483163 /Source="Nicolas_upshifts" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="upshifts" S_feature 1483277..1483449 /Source="Nicolas_S_feature" /locus_tag="new_1596301_1596473" /HighExp="T3.0H, T2.30H, S2, T3.30H, Lbtran, T4.0H, T5.0H, T1.30H, S1, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigWXY, SigA" /TUshortPSig="0.989, 0.0739, 1, 1" /TUlongSig="SigEF, Sig-" /TUlongPSig="0.569, 0.436" /label="S560" CDS 1483450..1484772 /gene="ftsA" /locus_tag="BSU_15280" /old_locus_tag="BSU15280" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15153768, 16159787, 16796675, 17015652, 23036588, 24224907" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15153768, 16159787, 16796675, 17015652, 23036588, 24224907; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division protein essential for Z-ring assembly" /protein_id="NP_389411.2" /db_xref="EnsemblGenomes-Gn:BSU15280" /db_xref="EnsemblGenomes-Tr:CAB13401" /db_xref="GOA:P28264" /db_xref="InterPro:IPR003494" /db_xref="InterPro:IPR020823" /db_xref="SubtiList:BG10231" /db_xref="UniProtKB/Swiss-Prot:P28264" /translation="MNNNELYVSLDIGTSNTKVIVGEMTDDSLNIIGVGNVPSEGLKK GSIVDIDETVHSIRKAFDQAERMVGFPLRKAIVGVNGNYINIQDTNGVVAVSSENKEI QVEDVRRVMEAAQVVSVPHEQLIVDVIPKQFIVDGRDEITDPKKMLGVRLEVEGTLIT GSKTILHNLLRCVERAGIEITDICLQPLAAGSAALSKDEKNLGVALIDIGGGSTTIAV FQNGHLTSTRVIPLGGENITKDISIGLRTSTEEAERVKKQLGHAYYDEASEDEIFEVT VIGTNQKQTFTQQEAANIIEARVEEILEIVSEELRSMGITDLPGGFVLTGGQAAMPGV MSLAQDVLQNNVRVASPNYIGVRDPQYMTGVGLIQFACRNARIQGRKIGFKMPEEAIQ EIAVSSSEEQEQHHHQNEVQQRPKGKQKTQAEHNKQSKMKKLLSMFWE*" /label="ftsA CDS" gene 1483450..1484772 /gene="ftsA" /locus_tag="BSU_15280" /old_locus_tag="BSU15280" /label="ftsA gene" upshifts complement(1483657) /Source="Nicolas_upshifts" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1483661..1483665) /Source="Nicolas_upshift_promotors" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1483680..1483684) /Source="Nicolas_upshift_promotors" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1484808..1485956 /gene="ftsZ" /locus_tag="BSU_15290" /old_locus_tag="BSU15290" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 12950927, 14527275, 15317782, 16159787, 16322744, 16549676, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12950927, 14527275, 15317782, 16159787, 16322744, 16549676, 22720735; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389412.2" /db_xref="EnsemblGenomes-Gn:BSU15290" /db_xref="EnsemblGenomes-Tr:CAB13402" /db_xref="GOA:P17865" /db_xref="InterPro:IPR000158" /db_xref="InterPro:IPR003008" /db_xref="InterPro:IPR008280" /db_xref="InterPro:IPR018316" /db_xref="InterPro:IPR020805" /db_xref="InterPro:IPR024757" /db_xref="InterPro:IPR036525" /db_xref="InterPro:IPR037103" /db_xref="PDB:2RHH" /db_xref="PDB:2RHJ" /db_xref="PDB:2RHL" /db_xref="PDB:2RHO" /db_xref="PDB:2VAM" /db_xref="PDB:2VXY" /db_xref="PDB:4U39" /db_xref="SubtiList:BG10232" /db_xref="UniProtKB/Swiss-Prot:P17865" /translation="MLEFETNIDGLASIKVIGVGGGGNNAVNRMIENEVQGVEYIAVN TDAQALNLSKAEVKMQIGAKLTRGLGAGANPEVGKKAAEESKEQIEEALKGADMVFVT AGMGGGTGTGAAPVIAQIAKDLGALTVGVVTRPFTFEGRKRQLQAAGGISAMKEAVDT LIVIPNDRILEIVDKNTPMLEAFREADNVLRQGVQGISDLIATPGLINLDFADVKTIM SNKGSALMGIGIATGENRAAEAAKKAISSPLLEAAIDGAQGVLMNITGGTNLSLYEVQ EAADIVASASDQDVNMIFGSVINENLKDEIVVTVIATGFIEQEKDVTKPQRPSLNQSI KTHNQSVPKREPKREEPQQQNTVSRHTSQPADDTLDIPTFLRNRNKRG*" /label="ftsZ CDS" gene 1484808..1485956 /gene="ftsZ" /locus_tag="BSU_15290" /old_locus_tag="BSU15290" /label="ftsZ gene" downshifts 1485930 /Source="Nicolas_upshifts" /id="D864" /incds=0 /nref=226 /ntot=389 /MaxReadThrough="2.85051" /MaxDrop="7.70428" /score="34.7919519" /energy="-13.7" /TU="U1267,U1271" /idTUdmin="U1269" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" SCAR join(1486051,1486058) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs20" N_region 1486052..1486057 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs20" S_feature <1486058..1486103 /Source="Nicolas_S_feature" /locus_tag="new_1606413_1606501" /HighExp="LoTm, S7, S8, BT, S6, S4, G/S, S3, S2, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.534" /TUlongSig="NA" /TUlongPSig="NA" /label="S565" promotor_-35 1486068..1486075 /Source="Nicolas_upshift_promotors" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1486088..1486107 /Source="Nicolas_upshift_promotors" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1486105 /Source="Nicolas_upshifts" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" CDS 1486162..1486956 /gene="ylmA" /locus_tag="BSU_15340" /old_locus_tag="BSU15340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16707683, 18083814; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389417.2" /db_xref="EnsemblGenomes-Gn:BSU15340" /db_xref="EnsemblGenomes-Tr:CAB13408" /db_xref="GOA:O31723" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13370" /db_xref="UniProtKB/Swiss-Prot:O31723" /translation="MILQLDNVSLKRNGKWILKDIHWKVEEKENWVLYGLNGAGKTAL LNMLCSYYFPTSGEMQVLGHEFGKTELGEKLRRKIGLVSAALQQKLYPADSAFEIALS GAYASIGLYETPSKETREKAIGLLEDLGAIEYADRRYETLSQGEKQRALIARALMADP ELLILDEPVTGLDFIAREKLLDTITYIANKENAPSILYVTHHAEEILPVFDKALLLKQ GEVFGSGEIKEMLTDQILSAFFDTPIHVLWNQDRPFLTRAEPITNA*" /label="ylmA CDS" gene 1486162..1486956 /gene="ylmA" /locus_tag="BSU_15340" /old_locus_tag="BSU15340" /label="ylmA gene" promotor_-35 1486874..1486877 /Source="Nicolas_upshift_promotors" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="promotor_-35" promotor_-10 1486892..1486911 /Source="Nicolas_upshift_promotors" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="promotor_-10" upshifts 1486900 /Source="Nicolas_upshifts" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="upshifts" misc_RNA 1486969..1487070 /gene="tswE" /locus_tag="BSU_misc_RNA_24" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswE RNA" gene 1486969..1487070 /gene="tswE" /locus_tag="BSU_misc_RNA_24" /label="tswE gene" downshifts 1487057 /Source="Nicolas_upshifts" /id="D867" /incds=0 /nref=7 /ntot=53 /MaxReadThrough="5.58534" /MaxDrop="4.3688" /score="-2.39598083" /energy="-7.1" /TU="U1278,U1279" /idTUdmin="U1274" /TUdmin=971 /isTUend="FALSE" /label="downshifts" CDS 1487158..1488438 /gene="thiQ" /locus_tag="BSU_15350" /old_locus_tag="BSU15350" /EC_number="3.5.1.-" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17618314" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17618314; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-formyl-4-amino-5-aminomethyl-2- methylpyrimidinedeformylase" /protein_id="NP_389418.2" /db_xref="EnsemblGenomes-Gn:BSU15350" /db_xref="EnsemblGenomes-Tr:CAB13409" /db_xref="GOA:O31724" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010182" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13371" /db_xref="UniProtKB/Swiss-Prot:O31724" /translation="MDQQIYSLQKKVEEHKEELIQLAKTLISYQTPAPPARNTEGIQS WIAGYLNELGFSIDKWDVYPGDPNVVGKLKGTDSADYYSLIINGHVDVAEVKEDEEWK HDPFHPIEKNGLLIGRGASDMKGGMACVLFAVKLIREASIELPGDLILQSVIGEEVGE AGTLECCKRGYHADFAIVADTSDMHIQGQGGVITGWIEIKSSQTFHDGTRRNMIHAGG GTFGASAIEKMAKIIAGLGELERHWSIMKSYPGFKPGTNTINPAVIEGGRHAAFIADE CRLWITVHFYPNETHDQVAAEIEDYVNRLSDSDIWLRENRPVFKWGGSSMIEDRGEIF PALEVDPGHPGVLALTASHQKVKRECPIIDVSQSVTDGGWLYDAGIPCVIYGPGDLHN AHSVNEKVSIEQLVEYTKIILDFIISWCSRKKEQ*" /label="thiQ CDS" gene 1487158..1488438 /gene="thiQ" /locus_tag="BSU_15350" /old_locus_tag="BSU15350" /label="thiQ gene" misc_feature complement(1488379..1488395) /Source="Nicolas_upshift_promotors" /id="U1280" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.407592407592408" /psig="0.715284715284715" /xcortree=1716 /SigmaFactorBS="ttcatgtcattgttcttttttccggctgcaccagctgatgat aaaatcgAGTATAATTTTTGTATActctactagctgctcaatcgataccttctcgttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1488384) /Source="Nicolas_upshifts" /id="U1280" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.407592407592408" /psig="0.715284715284715" /xcortree=1716 /SigmaFactorBS="ttcatgtcattgttcttttttccggctgcaccagctgatgat aaaatcgAGTATAATTTTTGTATActctactagctgctcaatcgataccttctcgttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1488459..1488464 /Source="Nicolas_upshift_promotors" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="promotor_-35" promotor_-10 1488480..1488498 /Source="Nicolas_upshift_promotors" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="promotor_-10" upshifts 1488484 /Source="Nicolas_upshifts" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="upshifts" CDS 1488521..1488766 /gene="ylmC" /locus_tag="BSU_15360" /old_locus_tag="BSU15360" /experiment="publication(s) with functional evidences, PMID:12429060, 23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12429060, 23396918; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="essential sporulation protein" /protein_id="NP_389419.1" /db_xref="EnsemblGenomes-Gn:BSU15360" /db_xref="EnsemblGenomes-Tr:CAB13410" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR014238" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG13372" /db_xref="UniProtKB/Swiss-Prot:O31725" /translation="MISISEFQVKDVVNVSNGKKLGSIGDIDINVTTGKIQAIILGGN GKVLGFFGKEEELVIPWRNIVKIGEDVILVRLSEPHA*" /label="ylmC CDS" gene 1488521..1488766 /gene="ylmC" /locus_tag="BSU_15360" /old_locus_tag="BSU15360" /label="ylmC gene" promotor_-35 1488682..1488690 /Source="Nicolas_upshift_promotors" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1488701..1488719 /Source="Nicolas_upshift_promotors" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1488709 /Source="Nicolas_upshifts" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" S_feature 1488767..1488877 /Source="Nicolas_S_feature" /locus_tag="new_1609165_1609275" /HighExp="T3.0H, S2, S1, T4.0H, T3.30H, T5.0H, T2.0H, BC, Gly, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.34150000000000003" /TUshortSig="SigH, SigEF, SigA, SigA" /TUshortPSig="1, 0.998, 0.976, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S566" misc_feature 1488869..1488888 /Source="Nicolas_upshift_promotors" /id="U1283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2210 /SigmaFactorBS="cacatttcatttagaaatatgcaaatcggcgctcaacgaatg cagtaagaTGTGGTAAAATAAGTGGGAAattccgcttttttaaatgtttgtcgaaagg t" /listShort="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1488879 /Source="Nicolas_upshifts" /id="U1283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2210 /SigmaFactorBS="cacatttcatttagaaatatgcaaatcggcgctcaacgaatg cagtaagaTGTGGTAAAATAAGTGGGAAattccgcttttttaaatgtttgtcgaaagg t" /listShort="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" CDS 1488929..1489765 /gene="ylmD" /locus_tag="BSU_15370" /old_locus_tag="BSU15370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16498617, 19737354; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved protein with laccase domain" /protein_id="NP_389420.1" /db_xref="EnsemblGenomes-Gn:BSU15370" /db_xref="EnsemblGenomes-Tr:CAB13411" /db_xref="GOA:O31726" /db_xref="InterPro:IPR003730" /db_xref="InterPro:IPR011324" /db_xref="SubtiList:BG13373" /db_xref="UniProtKB/Swiss-Prot:O31726" /translation="MNTYHPFSLTTPSTLMIQDWAQTNQNNKEVIAGFTTKNGGVSQK PFESLNTGLHVHDKDADVVKNREYIADMFNTDLQSWVFADQTHDNRVQKVTQRDRGKG AREYHTALKATDGIYTNEKNVFLALCFADCVPLFFYDPVKSLVGVAHAGWKGTVKQIG REMVKQWTEKEGSNPSDIYAVIGPSISGACYTVDDRVMDAVRALPVSADLAANQTAKA QYQLDLKELNRLILMDSGLASEQISVSGLCTESEPSLFYSHRRDQGKTGRMMSFIGMK EA*" /label="ylmD CDS" gene 1488929..1489765 /gene="ylmD" /locus_tag="BSU_15370" /old_locus_tag="BSU15370" /label="ylmD gene" CDS 1489772..1490464 /gene="ylmE" /locus_tag="BSU_15380" /old_locus_tag="BSU15380" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14526035, 24097949; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative PLP-containing enzyme" /protein_id="NP_389421.1" /db_xref="EnsemblGenomes-Gn:BSU15380" /db_xref="EnsemblGenomes-Tr:CAB13412" /db_xref="GOA:O31727" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR011078" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG13374" /db_xref="UniProtKB/Swiss-Prot:O31727" /translation="MRVVDNLRHINERINEACNRSGRSSDEVTVIAVTKYVSPERAQE AVDAGITCLGENRDAELLRKQELMKGNPEWHFIGSLQSRKAKSVVNSVSYIHSLDRLS LAKEIEKRAEGTVRCFVQVNTSLEPSKHGMKKEEVIPFIQELSGFEHILVAGLMTMAP LTDDQDQIRSCFRSLRELRDQVQKLNQPNAPCTELSMGMSNDFEIAIEEGATYIRIGS SLVGNETGGVQQ*" /label="ylmE CDS" gene 1489772..1490464 /gene="ylmE" /locus_tag="BSU_15380" /old_locus_tag="BSU15380" /label="ylmE gene" CDS 1490461..1490916 /gene="sepF" /locus_tag="BSU_15390" /old_locus_tag="BSU15390" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14526035, 16420366, 16796675, 18782755, 22912848, 24218584" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14526035, 16420366, 16796675, 18782755, 22912848, 24218584; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell division machinery factor" /protein_id="NP_389422.3" /db_xref="EnsemblGenomes-Gn:BSU15390" /db_xref="EnsemblGenomes-Tr:CAB13413" /db_xref="GOA:O31728" /db_xref="InterPro:IPR007561" /db_xref="InterPro:IPR023052" /db_xref="PDB:3ZIH" /db_xref="PDB:3ZII" /db_xref="SubtiList:BG13375" /db_xref="UniProtKB/Swiss-Prot:O31728" /translation="MSMKNKLKNFFSMEDEEYEYEYIETERESHEEHEQKEKPAYNGN KPAGKQNVVSLQSVQKSSKVVLSEPRVYAEAQEIADHLKNRRAVVVNLQRIQHDQAKR IVDFLSGTVYAIGGDIQRIGSDIFLCTPDNVDVSGTISELISEDEHQRW*" /label="sepF CDS" gene 1490461..1490916 /gene="sepF" /locus_tag="BSU_15390" /old_locus_tag="BSU15390" /label="sepF gene" CDS 1490923..1491195 /gene="ylmG" /locus_tag="BSU_15400" /old_locus_tag="BSU15400" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14526035, 19966467, 20359373; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination, distribution of nucleoids and osmotic tolerance" /protein_id="NP_389423.1" /db_xref="EnsemblGenomes-Gn:BSU15400" /db_xref="EnsemblGenomes-Tr:CAB13414" /db_xref="GOA:O31729" /db_xref="InterPro:IPR003425" /db_xref="SubtiList:BG13376" /db_xref="UniProtKB/Swiss-Prot:O31729" /translation="MILYQVFSVLSLLITIYSFALIIYIFMSWVPSTRETAVGRFLAS ICEPYLEPFRKIIPPIAMLDISPIVAILVLRFATTGLWGLYRMIAF*" /label="ylmG CDS" gene 1490923..1491195 /gene="ylmG" /locus_tag="BSU_15400" /old_locus_tag="BSU15400" /label="ylmG gene" downshifts 1491184 /Source="Nicolas_upshifts" /id="D868" /incds=0 /nref=16 /ntot=97 /MaxReadThrough="6.19839" /MaxDrop="4.93537" /score="-6.17078585" /energy="-15.2" /TU="U1278,U1281,U1282,U1283" /idTUdmin="U1281" /TUdmin="-1452" /isTUend="FALSE" /label="downshifts" CDS 1491256..1492029 /gene="ylmH" /locus_tag="BSU_15410" /old_locus_tag="BSU15410" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10093218, 14526035, 21141807; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination, RNA-binding fold" /protein_id="NP_389424.1" /db_xref="EnsemblGenomes-Gn:BSU15410" /db_xref="EnsemblGenomes-Tr:CAB13415" /db_xref="GOA:P71020" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11856" /db_xref="UniProtKB/Swiss-Prot:P71020" /translation="MSDIYQHFRKDERAFIDQALEWKRIVQEQYRMKLTDFLDPREQV ILSAVTGQADVGLAFSGGYDRAERKRAILFPEYITPEESDFELQAFNVRYADKFVSVD HRSLLGALMGIGLKRQKFGDIVFSETAVQLIVSADTADFVAAQLTQAGKAAVSLEKID LSDLNIPAVDVEIRDDTVSSLRLDAVCASMSRQSRQKSQTLVKNGLVKVNWKVVEDPS YIVAEGDMLSIRGFGRCSLTKIEGKTKKDKWRVTFERQK*" /label="ylmH CDS" gene 1491256..1492029 /gene="ylmH" /locus_tag="BSU_15410" /old_locus_tag="BSU15410" /label="ylmH gene" promotor_-35 1491745..1491752 /Source="Nicolas_upshift_promotors" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1491766..1491784 /Source="Nicolas_upshift_promotors" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1491789 /Source="Nicolas_upshifts" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" S_feature 1492030..1492122 /Source="Nicolas_S_feature" /locus_tag="new_1612428_1612520" /HighExp="C90, M0t90, C30, GM-0.1, Glucon, MG 5, GM 45, GM 5, GM 60, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigH, SigEF, SigA" /TUshortPSig="0.973, 1, 1, 0.998, 0.989" /TUlongSig="SigA" /TUlongPSig="0.976" /label="S567" CDS 1492123..1492617 /gene="divIVA" /locus_tag="BSU_15420" /old_locus_tag="BSU15420" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10724454, 12950914, 14526035, 15165232, 15554965, 16885474, 22108385, 22582279, 23264578, 24129255, 28674273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10724454, 12950914, 14526035, 15165232, 15554965, 16885474, 22108385, 22582279, 23264578, 24129255, 28674273; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389425.1" /db_xref="EnsemblGenomes-Gn:BSU15420" /db_xref="EnsemblGenomes-Tr:CAB13416" /db_xref="GOA:P71021" /db_xref="InterPro:IPR007793" /db_xref="InterPro:IPR019933" /db_xref="PDB:2WUJ" /db_xref="PDB:2WUK" /db_xref="SubtiList:BG11835" /db_xref="UniProtKB/Swiss-Prot:P71021" /translation="MPLTPNDIHNKTFTKSFRGYDEDEVNEFLAQVRKDYEIVLRKKT ELEAKVNELDERIGHFANIEETLNKSILVAQEAAEDVKRNSQKEAKLIVREAEKNADR IINESLSKSRKIAMEIEELKKQSKVFRTRFQMLIEAQLDLLKNDDWDHLLEYEVDAVF EEKE*" /label="divIVA CDS" gene 1492123..1492617 /gene="divIVA" /locus_tag="BSU_15420" /old_locus_tag="BSU15420" /label="divIVA gene" promotor_-35 1492630..1492637 /Source="Nicolas_upshift_promotors" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1492651..1492670 /Source="Nicolas_upshift_promotors" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1492658 /Source="Nicolas_upshifts" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1492680..1492906 /gene="iswA" /locus_tag="BSU_misc_RNA_25" /product="T-box riboswitch specific of isoleucine tRNA" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /label="iswA RNA" gene 1492680..1492906 /gene="iswA" /locus_tag="BSU_misc_RNA_25" /label="iswA gene" downshifts 1492873 /Source="Nicolas_upshifts" /id="D869" /incds=0 /nref=43 /ntot=100 /MaxReadThrough="7.76706" /MaxDrop="5.97038" /score="48.8352635" /energy="-19.4" /TU="U1278,U1282,U1283,U1284,U1285" /idTUdmin="U1281" /TUdmin=237 /isTUend="FALSE" /label="downshifts" CDS 1492959..1495724 /gene="ileS" /locus_tag="BSU_15430" /old_locus_tag="BSU15430" /EC_number="6.1.1.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16697013, 17043414, 17095543, 28139725; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoleucyl-tRNA synthetase" /protein_id="NP_389426.2" /db_xref="EnsemblGenomes-Gn:BSU15430" /db_xref="EnsemblGenomes-Tr:CAB13417" /db_xref="GOA:Q45477" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002301" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR023585" /db_xref="InterPro:IPR033708" /db_xref="SubtiList:BG11792" /db_xref="UniProtKB/Swiss-Prot:Q45477" /translation="MDFKDTLLMPKTDFPMRGNLPNREPDIQKKWEEEDIYRLVQERT KDRPKFVLHDGPPYANGDIHMGHALNKILKDFIVRYKSMSGYNAPYVPGWDTHGLPIE TALTKNKKVNRKEMSVAEFRKLCEEYAWKQIEGQREQFKRLGVRGDWENPYVTLKPEY EAQQIRVFGEMAKRGYIYKGLKPVNWSPSSESALAEAEIEYQDKRSASIYVAFGVKDG KGVLENGERIIIWTTTPWTIPANLGISVHPDLEYSVIAVGEDRFVVASALVENVASAC GFDQYEVTRTVKGKDLENIIAEHPLYGRDSLVMLGEHVTTDAGTGCVHTAPGHGEDDF IIGQKYGLDVLCPVDEKGVMTSEAPGFEGMFYDDANKAITQQLDEKGALVKLEFITHS YPHDWRTKKPTIFRATAQWFASIKDFRSDLLDAIKETKWVPEWGEQRLHNMVRDRGDW CISRQRAWGVPIPVFYAENGEPVITDETIEHVSELFRQHGSNIWFEKEAKDLLPEGFT HPGSPNGTFTKEQDIMDVWFDSGSSHQAVLEERDDLVRPADLYLEGSDQYRGWFNSSL STAVAVTGKAPYKGVLSHGFALDGEGRKMSKSIGNVVVPAKVMKQLGADILRLWVSSV DYQADVRVSDAILKQVAEVYRKIRNTFRFLHGNLFDFDPKTNAVAVEDLREVDQYMLI KLNKLIDKVKKAYDEYEFAVVYHSIHNFCTIELSSFYLDFAKDIVYIEHADHPDRRSM QTVFYETLLALVKLSAPILPHTADELWSHLTFVEEQSVQLTDMPETITVPNSEATEEK FDRFMALRDDVLKALETARNEKIIGKSLEANLKLYPNKENKELLASIKENLSQLFIVS ELTISEENEAPNDAQSFATGKIAVEKAEGEMCERSRVISKDVGANPKYPTLSLRNAEI VEKYYQK*" /label="ileS CDS" gene 1492959..1495724 /gene="ileS" /locus_tag="BSU_15430" /old_locus_tag="BSU15430" /label="ileS gene" downshifts 1495715 /Source="Nicolas_upshifts" /id="D870" /incds=0 /nref=233 /ntot=261 /MaxReadThrough="2.6695" /MaxDrop="6.91924" /score="40.2175565" /energy="-13.9" /TU="NA" /idTUdmin="U1278" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts complement(1495770) /Source="Nicolas_upshifts" /id="D871" /incds=0 /nref=6 /ntot=17 /MaxReadThrough="1.29709" /MaxDrop="3.66645" /score="13.8608728" /energy="-15.6" /TU="NA" /idTUdmin="U1275" /TUdmin="-12534" /isTUend="FALSE" /label="downshifts" promotor_-35 1495805..1495811 /Source="Nicolas_upshift_promotors" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="promotor_-35" promotor_-10 1495826..1495837 /Source="Nicolas_upshift_promotors" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="promotor_-10" upshifts 1495826 /Source="Nicolas_upshifts" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="upshifts" CDS 1495869..1496243 /gene="ylyA" /locus_tag="BSU_15440" /old_locus_tag="BSU15440" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15496987, 23123912, 23678950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15496987, 23123912, 23678950; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-related RNA polymerase-binding factor" /protein_id="NP_389427.2" /db_xref="EnsemblGenomes-Gn:BSU15440" /db_xref="EnsemblGenomes-Tr:CAB13418" /db_xref="GOA:Q45478" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR016841" /db_xref="InterPro:IPR020458" /db_xref="SubtiList:BG11795" /db_xref="UniProtKB/Swiss-Prot:Q45478" /translation="MNDQLTAIYTELLLMKEELQSRLFEYSCFQVSTSPQAAINQKQK ATLIYHIKEELQDVLLALSKIENGTFGYCEETGAPIPLAKLAVLPTARTANDFLYSVQ FEKKTLPIWKSTDIEYGQALYE*" /label="ylyA CDS" gene 1495869..1496243 /gene="ylyA" /locus_tag="BSU_15440" /old_locus_tag="BSU15440" /label="ylyA gene" promotor_-35 1496275..1496279 /Source="Nicolas_upshift_promotors" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-35" upshifts 1496294 /Source="Nicolas_upshifts" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="upshifts" promotor_-10 1496295..1496314 /Source="Nicolas_upshift_promotors" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-10" CDS 1496346..1496810 /gene="lspA" /locus_tag="BSU_15450" /old_locus_tag="BSU15450" /EC_number="3.4.23.36" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9880550, 9882689, 10497172, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9880550, 9882689, 10497172, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="signal peptidase II" /protein_id="NP_389428.1" /db_xref="EnsemblGenomes-Gn:BSU15450" /db_xref="EnsemblGenomes-Tr:CAB13419" /db_xref="GOA:Q45479" /db_xref="InterPro:IPR001872" /db_xref="SubtiList:BG11793" /db_xref="UniProtKB/Swiss-Prot:Q45479" /translation="MLYYMIALLIIAADQLTKWLVVKNMELGQSIPIIDQVFYITSHR NTGAAWGILAGQMWFFYLITTAVIIGIVYYIQRYTKGQRLLGVALGLMLGGAIGNFID RAVRQEVVDFIHVIIVNYNYPIFNIADSSLCVGVMLLFIQMLLDSGKKKKEQ*" /label="lspA CDS" gene 1496346..1496810 /gene="lspA" /locus_tag="BSU_15450" /old_locus_tag="BSU15450" /label="lspA gene" CDS 1496812..1497723 /gene="rluD" /locus_tag="BSU_15460" /old_locus_tag="BSU15460" /EC_number="4.2.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15078091, 15928344, 17188032, 17937767, 18032607, 20817755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pseudouridylate synthase" /protein_id="NP_389429.3" /db_xref="EnsemblGenomes-Gn:BSU15460" /db_xref="EnsemblGenomes-Tr:CAB13420" /db_xref="GOA:Q45480" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11796" /db_xref="UniProtKB/Swiss-Prot:Q45480" /translation="MNQIDITASEEQKSERIDKFLASTENDWSRTQVQQWVKDGQVVV NGSAVKANYKIQPGDQVTVTVPEPEALDVLAEPMDLDIYYEDQDVLVVNKPRGMVVHP APGHLTGTLVNGLMAHCTDLSGINGVMRPGIVHRIDKDTSGLLMVAKNDMAHESLVNQ LVNKTVTRKYTAVVHGLISHDDGTIDAPIGRDKKDRQSMTVTRDGKNAVTHFHVLERF QDFTLVECQLETGRTHQIRVHMKYIGFPLAGDPKYGPRKTIDFNGQALHAGVLGFDHP RTGEYVEFEAPLPEDMAELIENLRKNG*" /label="rluD CDS" gene 1496812..1497723 /gene="rluD" /locus_tag="BSU_15460" /old_locus_tag="BSU15460" /label="rluD gene" promotor_-35 1497718..1497725 /Source="Nicolas_upshift_promotors" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-35" promotor_-10 1497740..1497759 /Source="Nicolas_upshift_promotors" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-10" upshifts 1497754 /Source="Nicolas_upshifts" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="upshifts" misc_RNA 1497763..1497879 /gene="pyaA" /locus_tag="BSU_misc_RNA_26" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" /label="pyaA RNA" gene 1497763..1497879 /gene="pyaA" /locus_tag="BSU_misc_RNA_26" /label="pyaA gene" CDS 1497906..1498451 /gene="pyrR" /locus_tag="BSU_15470" /old_locus_tag="BSU15470" /EC_number="2.4.2.9" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7798145, 9932459, 12482852, 15716449, 17322189, 18678934" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7798145, 9932459, 12482852, 15716449, 17322189, 18678934; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional attenuator and uracil phosphoribosyltransferase activity" /protein_id="NP_389430.1" /db_xref="EnsemblGenomes-Gn:BSU15470" /db_xref="EnsemblGenomes-Tr:CAB13421" /db_xref="GOA:P39765" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR023050" /db_xref="InterPro:IPR029057" /db_xref="PDB:1A3C" /db_xref="PDB:1A4X" /db_xref="PDB:4P82" /db_xref="SubtiList:BG10712" /db_xref="UniProtKB/Swiss-Prot:P39765" /translation="MNQKAVILDEQAIRRALTRIAHEMIERNKGMNNCILVGIKTRGI YLAKRLAERIEQIEGNPVTVGEIDITLYRDDLSKKTSNDEPLVKGADIPVDITDQKVI LVDDVLYTGRTVRAGMDALVDVGRPSSIQLAVLVDRGHRELPIRADYIGKNIPTSKSE KVMVQLDEVDQNDLVAIYENE*" /label="pyrR CDS" gene 1497906..1498451 /gene="pyrR" /locus_tag="BSU_15470" /old_locus_tag="BSU15470" /label="pyrR gene" downshifts complement(1498100) /Source="Nicolas_upshifts" /id="D872" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="1.85132" /MaxDrop="2.50006" /score="0.812637138" /energy="-7" /TU="NA" /idTUdmin="U1275" /TUdmin="-14864" /isTUend="FALSE" /label="downshifts" downshifts 1498442 /Source="Nicolas_upshifts" /id="D873" /incds=0 /nref=13 /ntot=149 /MaxReadThrough="8.16191" /MaxDrop="3.4492" /score="16.3570883" /energy="-11.5" /TU="U1287,U1288" /idTUdmin="U1286" /TUdmin=704 /isTUend="FALSE" /label="downshifts" misc_RNA 1498455..1498572 /gene="pyaB" /locus_tag="BSU_misc_RNA_27" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" /label="pyaB RNA" gene 1498455..1498572 /gene="pyaB" /locus_tag="BSU_misc_RNA_27" /label="pyaB gene" CDS 1498625..1499932 /gene="pyrP" /locus_tag="BSU_15480" /old_locus_tag="BSU15480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8206848, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uracil permease" /protein_id="NP_389431.2" /db_xref="EnsemblGenomes-Gn:BSU15480" /db_xref="EnsemblGenomes-Tr:CAB13422" /db_xref="GOA:P39766" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR029935" /db_xref="SubtiList:BG10992" /db_xref="UniProtKB/Swiss-Prot:P39766" /translation="MSKKKVNLGVRDVPTPFSWVSFSLQHLFAMFGSTILVPKLVGMS PAVALVTSGIGTLAYLLITKGQIPAYLGSSFAFISPIILVKATGGPGAAMVGAFLAGL VYGLIALLIRQLGTGWLMKILPPVVVGPVIIVIGLGLASTAVNMAMYADPNASELVYS LKHFSVAGVTLAITIICAIFLRGFLSLIPVLIGIIGGYLFALTQGIVNFQPVLDAKWF AVPEFIIPFKDYSPSVTLGIAAAMVPVAFVTMSEHIGHQMVLSKVVGQDFIKKPGLHR SIMGDSVATILASLIGGPPTTTYGENIGVLAITRVFSVFVIGGAAVIALCFGFIGKIS ALISSVPSAVMGGVSFLLFGIIASSGLRMLIDNKIDYENNRNLIITSVILVIGVGGAF IQVSQGGFQVSGMALAAIVGVILNLILPQAKEEQADTSEQHHI*" /label="pyrP CDS" gene 1498625..1499932 /gene="pyrP" /locus_tag="BSU_15480" /old_locus_tag="BSU15480" /label="pyrP gene" misc_RNA 1499933..1500047 /gene="pyaC" /locus_tag="BSU_misc_RNA_28" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" /label="pyaC RNA" gene 1499933..1500047 /gene="pyaC" /locus_tag="BSU_misc_RNA_28" /label="pyaC gene" CDS 1500078..1500992 /gene="pyrB" /locus_tag="BSU_15490" /old_locus_tag="BSU15490" /EC_number="2.1.3.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8535162, 16321950, 21663747" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8535162, 16321950, 21663747; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate carbamoyltransferase" /protein_id="NP_389432.2" /db_xref="EnsemblGenomes-Gn:BSU15490" /db_xref="EnsemblGenomes-Tr:CAB13423" /db_xref="GOA:P05654" /db_xref="InterPro:IPR002082" /db_xref="InterPro:IPR006130" /db_xref="InterPro:IPR006131" /db_xref="InterPro:IPR006132" /db_xref="InterPro:IPR036901" /db_xref="PDB:2AT2" /db_xref="PDB:3R7D" /db_xref="PDB:3R7F" /db_xref="PDB:3R7L" /db_xref="SubtiList:BG10713" /db_xref="UniProtKB/Swiss-Prot:P05654" /translation="MKHLTTMSELSTEEIKDLLQTAQELKSGKTDNQLTGKFAANLFF EPSTRTRFSFEVAEKKLGMNVLNLDGTSTSVQKGETLYDTIRTLESIGVDVCVIRHSE DEYYEELVSQVNIPILNAGDGCGQHPTQSLLDLMTIYEEFNTFKGLTVSIHGDIKHSR VARSNAEVLTRLGARVLFSGPSEWQDEENTFGTYVSMDEAVESSDVVMLLRIQNERHQ SAVSQEGYLNKYGLTVERAERMKRHAIIMHPAPVNRGVEIDDSLVESEKSRIFKQMKN GVFIRMAVIQRALQTNVKRGEAAYVISH*" /label="pyrB CDS" gene 1500078..1500992 /gene="pyrB" /locus_tag="BSU_15490" /old_locus_tag="BSU15490" /label="pyrB gene" CDS 1500976..1502262 /gene="pyrC" /locus_tag="BSU_15500" /old_locus_tag="BSU15500" /EC_number="3.5.2.3" /function="2: Purines, pyrimidines, nucleosides, and nucleotides" /experiment="publication(s) with functional evidences, PMID:7516791, 16522191, 21045288" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7516791, 16522191, 21045288; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotase" /protein_id="NP_389433.2" /db_xref="EnsemblGenomes-Gn:BSU15500" /db_xref="EnsemblGenomes-Tr:CAB13424" /db_xref="GOA:P25995" /db_xref="InterPro:IPR002195" /db_xref="InterPro:IPR004722" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG10714" /db_xref="UniProtKB/Swiss-Prot:P25995" /translation="MSYLIKNGWILNENGEKTQADIRVTGETITAIGKLDATDNETVI DAKGLLVSPGFVDLHVHFREPGGEKKETIETGAKAAARGGYTTVAAMPNTRPVPDTKE QMEWVQNRIKETSCVRVLPYASITIRQIGDEMTNFEALKEAGAFAFTDDGVGIQTAGM MYEAMKRAAAIDKAIVAHCEDNSLIYGGSVHEGTFSKANGLNGIPSVCESVHIARDVL LAEAANCHYHVCHISTKESVRVVRDAKKAGIRVTAEVSPHHLLLCDEDIPGLDTNYKM NPPLRSPEDRAALIEGLLDGTIDFIATDHAPHTEEEKNTEMKLAPFGIVGLETAFPLL YTHFVKNGSWSLKQLIDYMTIKPCEAFGLPYGTLQTGQAADITLIDLEKEAVIDKETF LSKGKNTPFNGISCTGWPVATIAAGKLAYEEGRLVK*" /label="pyrC CDS" gene 1500976..1502262 /gene="pyrC" /locus_tag="BSU_15500" /old_locus_tag="BSU15500" /label="pyrC gene" CDS 1502259..1503353 /gene="pyrAA" /locus_tag="BSU_15510" /old_locus_tag="BSU15510" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1709162, 11390694, 23750951; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-specific carbamoyl-phosphate synthetase (small subunit, glutaminase subunit)" /protein_id="NP_389434.1" /db_xref="EnsemblGenomes-Gn:BSU15510" /db_xref="EnsemblGenomes-Tr:CAB13425" /db_xref="GOA:P25993" /db_xref="InterPro:IPR002474" /db_xref="InterPro:IPR006274" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR035686" /db_xref="InterPro:IPR036480" /db_xref="SubtiList:BG10715" /db_xref="UniProtKB/Swiss-Prot:P25993" /translation="MKRRLVLENGAVFEGEAFGSLEHNMGEVVFNTGMTGYQEILSDP SYCGQIVTLTYPLIGNYGINRDDFESITPFVKGLIIKELCELPSNWRSAYTLDEYLKM KNIPGLQGIDTRKLTRMIRTAGALKGTFASSDEDIEAVLKRLNETELPRNQVSQVSAK TAYPSPGRGKRIVLVDFGMKHGILRELNKRKCDVIVVPYNITAEEVLQLKPDGIMLSN GPGDPKDVPEAIEMIKGVLGKVPLFGICLGHQLFALACGANTEKMKFGHRGSNHPVKE LATGKVALTSQNHGYTVSSISKTELEVTHIAINDDTIEGLKHKTLPAFTVQYHPEASP GPEDANHLFDRFIEMIETTEKEGEAVCQNA*" /label="pyrAA CDS" gene 1502259..1503353 /gene="pyrAA" /locus_tag="BSU_15510" /old_locus_tag="BSU15510" /label="pyrAA gene" CDS 1503338..1506553 /gene="pyrAB" /locus_tag="BSU_15520" /old_locus_tag="BSU15520" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 216664, 6120161, 10732707, 23750951; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-specific carbamoyl-phosphate synthetase (large subunit)" /protein_id="NP_389435.1" /db_xref="EnsemblGenomes-Gn:BSU15520" /db_xref="EnsemblGenomes-Tr:CAB13426" /db_xref="GOA:P25994" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005480" /db_xref="InterPro:IPR005483" /db_xref="InterPro:IPR006275" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR033937" /db_xref="InterPro:IPR036897" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG10716" /db_xref="UniProtKB/Swiss-Prot:P25994" /translation="MPKRVDINKILVIGSGPIIIGQAAEFDYAGTQACLALKEEGYEV ILVNSNPATIMTDTEMADRVYIEPLTPEFLTRIIRKERPDAILPTLGGQTGLNLAVEL SERGVLAECGVEVLGTKLSAIQQAEDRDLFRTLMNELNEPVPESEIIHSLEEAEKFVS QIGFPVIVRPAYTLGGTGGGICSNETELKEIVENGLKLSPVHQCLLEKSIAGYKEIEY EVMRDSQDHAIVVCNMENIDPVGIHTGDSIVVAPSQTLSDREYQLLRNVSLKLIRALG IEGGCNVQLALDPDSFQYYIIEVNPRVSRSSALASKATGYPIAKLAAKIAVGLSLDEM MNPVTGKTYAAFEPALDYVVSKIPRWPFDKFESANRKLGTQMKATGEVMAIGRTLEES LLKAVRSLEADVYHLELKDAADISDELLEKRIKKAGDERLFYLAEAYRRGYTVEDLHE FSAIDVFFLHKLFGIVQFEKELKANAGDTDVLRRAKELGFSDQYISREWKMKESELYS LRKQAGIAPVFKMVDTCAAEFESETPYFYSTYEEENESVVTDKKSVMVLGSGPIRIGQ GVEFDYATVHSVWAIKQAGYEAIIVNNNPETVSTDFSISDKLYFEPLTIEDVMHIIDL EQPMGVVVQFGGQTAINLADELSARGVKILGTSLEDLDRAEDRDKFEQALGELGVPQP LGKTATSVNQAVSIASDIGYPVLVRPSYVLGGRAMEIVYHEEELLHYMKNAVKINPQH PVLIDRYLTGKEIEVDAVSDGETVVIPGIMEHIERAGVHSGDSIAVYPPQSLTEDIKK KIEQYTIALAKGLNIVGLLNIQFVLSQGEVYVLEVNPRSSRTVPFLSKITGIPMANLA TKIILGQKLAAFGYTEGLQPEQQGVFVKAPVFSFAKLRRVDITLGPEMKSTGEVMGKD STLEKALYKALIASGIQIPNYGSVLLTVADKDKEEGLAIAKRFHAIGYNILATEGTAG YLKEASIPAKVVGKIGQDGPNLLDVIRNGEAQFVINTLTKGKQPARDGFRIRRESVEN GVACLTSLDTAEAILRVLESMTFRADQMPAVNTNQEAAVTI*" /label="pyrAB CDS" gene 1503338..1506553 /gene="pyrAB" /locus_tag="BSU_15520" /old_locus_tag="BSU15520" /label="pyrAB gene" CDS 1506550..1507320 /gene="pyrK" /locus_tag="BSU_15530" /old_locus_tag="BSU15530" /EC_number="1.3.98.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:169225, 10545205, 11188687, 15299876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 169225, 10545205, 11188687, 15299876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotate dehydrogenase (electron transfer subunit)" /protein_id="NP_389436.1" /db_xref="EnsemblGenomes-Gn:BSU15530" /db_xref="EnsemblGenomes-Tr:CAB13427" /db_xref="GOA:P25983" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR012165" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR019480" /db_xref="InterPro:IPR023455" /db_xref="InterPro:IPR037117" /db_xref="SubtiList:BG10717" /db_xref="UniProtKB/Swiss-Prot:P25983" /translation="MKKAYLTVCSNQQIADRVFQMVLKGELVQGFTTPGQFLHLKVSE AVTPLLRRPISIADVNFEKNEVTIIYRVDGEGTRLLSLKQQGELVDVLGPLGNGFPVN EVQPGKTALLVGGGVGVPPLQELSKRLIEKGVNVIHVLGFQSAKDVFYEEECRQYGDT YVATADGSYGETGFVTDVIKRKKLEFDILLSCGPTPMLKALKQEYAHKEVYLSMEERM GCGIGACFACVCHTNESETSYVKVCLDGPVFKAQEVAL*" /label="pyrK CDS" gene 1506550..1507320 /gene="pyrK" /locus_tag="BSU_15530" /old_locus_tag="BSU15530" /label="pyrK gene" CDS 1507320..1508255 /gene="pyrD" /locus_tag="BSU_15540" /old_locus_tag="BSU15540" /EC_number="1.3.1.15" /experiment="publication(s) with functional evidences, PMID:4380263, 10545205" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4380263, 10545205; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotate dehydrogenase (catalytic subunit)" /protein_id="NP_389437.1" /db_xref="EnsemblGenomes-Gn:BSU15540" /db_xref="EnsemblGenomes-Tr:CAB13428" /db_xref="GOA:P25996" /db_xref="InterPro:IPR001295" /db_xref="InterPro:IPR005720" /db_xref="InterPro:IPR012135" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024920" /db_xref="InterPro:IPR033888" /db_xref="SubtiList:BG10718" /db_xref="UniProtKB/Swiss-Prot:P25996" /translation="MLEVKLPGLDLKNPIIPASGCFGFGKEFSRFYDLSCLGAIMIKA TTKEPRFGNPTPRVAETGAGMLNAIGLQNPGLDSVLHHELPWLEQFDTPIIANVAGSQ VDDYVEVAEHISKAPNVHALELNISCPNVKTGGIAFGTNPEMAADLTKAVKEVSDVPV YVKLSPNVANITEIALAIEEAGADGLTMINTLIGMRLDLKTGKPILANKTGGLSGPAV KPVAIRMVYEVSQMVNIPIIGMGGVQTAEDALEFLLAGASAVAVGTANFVNPFACPEI IEQLPSVLLQYGYQSIEECIGRSWNHEKQPAHHRA*" /label="pyrD CDS" gene 1507320..1508255 /gene="pyrD" /locus_tag="BSU_15540" /old_locus_tag="BSU15540" /label="pyrD gene" CDS 1508224..1508943 /gene="pyrF" /locus_tag="BSU_15550" /old_locus_tag="BSU15550" /EC_number="4.1.1.23" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10681442, 11390694, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10681442, 11390694, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="orotidine 5'-phosphate decarboxylase" /protein_id="NP_389438.1" /db_xref="EnsemblGenomes-Gn:BSU15550" /db_xref="EnsemblGenomes-Tr:CAB13429" /db_xref="GOA:P25971" /db_xref="InterPro:IPR001754" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR014732" /db_xref="InterPro:IPR018089" /db_xref="PDB:1DBT" /db_xref="SubtiList:BG10719" /db_xref="UniProtKB/Swiss-Prot:P25971" /translation="MKNNLPIIALDFASAEETLAFLAPFQQEPLFVKVGMELFYQEGP SIVKQLKERNCELFLDLKLHDIPTTVNKAMKRLASLGVDLVNVHAAGGKKMMQAALEG LEEGTPAGKKRPSLIAVTQLTSTSEQIMKDELLIEKSLIDTVVHYSKQAEESGLDGVV CSVHEAKAIYQAVSPSFLTVTPGIRMSEDAANDQVRVATPAIAREKGSSAIVVGRSIT KAEDPVKAYKAVRLEWEGIKS*" /label="pyrF CDS" gene 1508224..1508943 /gene="pyrF" /locus_tag="BSU_15550" /old_locus_tag="BSU15550" /label="pyrF gene" CDS 1508922..1509572 /gene="pyrE" /locus_tag="BSU_15560" /old_locus_tag="BSU15560" /EC_number="2.4.2.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9305779, 22447609, 23405251; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="orotate phosphoribosyltransferase" /protein_id="NP_389439.1" /db_xref="EnsemblGenomes-Gn:BSU15560" /db_xref="EnsemblGenomes-Tr:CAB13430" /db_xref="GOA:P25972" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR004467" /db_xref="InterPro:IPR023031" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10720" /db_xref="UniProtKB/Swiss-Prot:P25972" /translation="MGGNQILKQIIAKHLLDIQAVFLRPNEPFTWASGILSPIYCDNR LTLSFPEVRNDVASGISKLVKEHFPEAEMIAGTATAGIPHAALAADHLNLPMCYVRSK PKAHGKGNQIEGAVQEGQKTVVIEDLISTGGSVLEACAALQAAGCEVLGVVSIFTYGL PKAEEAFAKAELPYYSLTDYDTLTEVALENGNIHSDDLKKLQTWKRNPESKDWFKK*" /label="pyrE CDS" gene 1508922..1509572 /gene="pyrE" /locus_tag="BSU_15560" /old_locus_tag="BSU15560" /label="pyrE gene" downshifts 1509574 /Source="Nicolas_upshifts" /id="D874" /incds=0 /nref=17 /ntot=184 /MaxReadThrough="3.91018" /MaxDrop="5.49939" /score="33.4515727" /energy="-9" /TU="U1287,U1288" /idTUdmin="U1287" /TUdmin="-115" /isTUend="FALSE" /label="downshifts" S_feature 1509619..1509691 /Source="Nicolas_S_feature" /locus_tag="new_1630017_1630089" /HighExp="Cold, Gly, MG 5, S0, LPh, M/G, GM 60, MG t5, Mal, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S568" promotor_-35 1509671..1509678 /Source="Nicolas_upshift_promotors" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1509692..1509711 /Source="Nicolas_upshift_promotors" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1509693 /Source="Nicolas_upshifts" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1509717..1509822 /gene="mswE" /locus_tag="BSU_misc_RNA_29" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /label="mswE RNA" gene 1509717..1509822 /gene="mswE" /locus_tag="BSU_misc_RNA_29" /label="mswE gene" S_feature 1509823..1509983 /Source="Nicolas_S_feature" /locus_tag="new_1630221_1630381" /HighExp="MG 10, B60, MG 5, MG t5, M9-exp, MG 25, MG 60, MG 15, GM 90, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S569" CDS 1509984..1510685 /gene="cysH" /locus_tag="BSU_15570" /old_locus_tag="BSU15570" /EC_number="1.8.4.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10094622, 11004190, 12072441, 16267287, 18456801" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 11004190, 12072441, 16267287, 18456801; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(phospho)adenosine phosphosulfate reductase" /protein_id="NP_389440.1" /db_xref="EnsemblGenomes-Gn:BSU15570" /db_xref="EnsemblGenomes-Tr:CAB13431" /db_xref="GOA:P94498" /db_xref="InterPro:IPR002500" /db_xref="InterPro:IPR004511" /db_xref="InterPro:IPR011798" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11930" /db_xref="UniProtKB/Swiss-Prot:P94498" /translation="MLTYDNWEEPTITFPEDDPYKGALSVLKWAYGHYGDQLVYACSF GIEGIVLIDLIYKVKKDAEIVFLDTGLHFKETYETIERVKERYPGLNIILKKPDLTLE EQAEEHGDKLWEREPNQCCYLRKVVPLREALSGHPAWLSGLRRDQGPSRANTNFLNKD EKFKSVKVCPLIHWTWKDIWRYTSRNELDYNPLHDQGYPSIGCAPCTSPAFTAEDLRS GRWNGMAKTECGLHE*" /label="cysH CDS" gene 1509984..1510685 /gene="cysH" /locus_tag="BSU_15570" /old_locus_tag="BSU15570" /label="cysH gene" CDS 1510697..1511761 /gene="cysP" /locus_tag="BSU_15580" /old_locus_tag="BSU15580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 10784039, 11004190, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 10784039, 11004190, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfate permease" /protein_id="NP_389441.1" /db_xref="EnsemblGenomes-Gn:BSU15580" /db_xref="EnsemblGenomes-Tr:CAB13432" /db_xref="GOA:O34734" /db_xref="InterPro:IPR001204" /db_xref="SubtiList:BG13377" /db_xref="UniProtKB/Swiss-Prot:O34734" /translation="MELAAILFSLFFAMNIGASGAAASMGVAYGSGAIKKKTYALILC AVGVFAGAVIGGGEVVKTISSGIIPEQTITLTIVCIIIGAAALSLFTANLLGIPLSTS EVTVGAVVGVGVAYKVLFVNNLLIIVSFWVFVPLFAFGFTYFVSKLFRYFKIEVKSSK KQKILGIVLLVAGFFEAFSAGMNNVANAVGPLVAAGVLDVGKGTLYGGAFVALGALLL GRRVLETNGKKITRFSKGEGILLSGTGAGLVIISSVFGMPVPLAQVTSSSIIGIGMAK NGPNVFHKQVVQTMLKVWIVSPFLSLSISYLLVSLFLKADYYSIFIMVSVLLAAGGAI SLTKAIRKERRSVHEQGGGI*" /label="cysP CDS" gene 1510697..1511761 /gene="cysP" /locus_tag="BSU_15580" /old_locus_tag="BSU15580" /label="cysP gene" CDS 1511810..1512958 /gene="sat" /locus_tag="BSU_15590" /old_locus_tag="BSU15590" /EC_number="2.7.7.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094622, 11004190, 11274114; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sulfate adenylyltransferase" /protein_id="NP_389442.1" /db_xref="EnsemblGenomes-Gn:BSU15590" /db_xref="EnsemblGenomes-Tr:CAB13433" /db_xref="GOA:O34764" /db_xref="InterPro:IPR002650" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020792" /db_xref="InterPro:IPR024951" /db_xref="InterPro:IPR025980" /db_xref="SubtiList:BG13378" /db_xref="UniProtKB/Swiss-Prot:O34764" /translation="MSLAPHGGTLVNRVDESYDVSGIQKEIELDLISFADLELIGIGA YSPIEGFFNEKDYVSVVENMRLSSGVVWSLPITLPVDAQKAAELSLGETVKLTYEGET YGVIQIEDLYVPDKQKEAVNVYKTDEQEHPGVKKLFSRGNTYVGGPITLIKKASKQFP EFTFEPSETRRQFAEKGWETIVGFQTRNPVHRAHEYIQKTALETVDGLFLNPLVGETK SDDIPADVRMESYQVLLDHYYPKDRVFLGVFLAAMRYAGPREAIFHALVRKNYGCTHF IVGRDHAGVGDYYGTYEAQELFDTFKPEELGITPLKFEHSFFCKKCGNMGTAKTCPHG REHHVILSGTKVRGMLRDGVLPPAEFSRKEVVEVLIKGMKKKEEVGVS*" /label="sat CDS" gene 1511810..1512958 /gene="sat" /locus_tag="BSU_15590" /old_locus_tag="BSU15590" /label="sat gene" upshifts complement(1511899) /Source="Nicolas_upshifts" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1511911..1511915) /Source="Nicolas_upshift_promotors" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1511933..1511934) /Source="Nicolas_upshift_promotors" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1512971..1513564 /gene="cysC" /locus_tag="BSU_15600" /old_locus_tag="BSU15600" /EC_number="2.7.1.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1332767, 10094622, 11004190, 19067028, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylylsulfate kinase" /protein_id="NP_389443.1" /db_xref="EnsemblGenomes-Gn:BSU15600" /db_xref="EnsemblGenomes-Tr:CAB13434" /db_xref="GOA:O34577" /db_xref="InterPro:IPR002891" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13379" /db_xref="UniProtKB/Swiss-Prot:O34577" /translation="MTNRDIVWHEASITKEEYQQKNKHKSSILWLTGLSGSGKSTIAN AAARELFEQGYQVIVLDGDNIRHGLNRDLGFSDEDRKENIRRIGEVAKLFVQQGTIVI TAFISPFREDRQQVRELVEAGEFNEVYIKCDLDICEQRDPKGLYKKARNGEIPFFTGI DSPYEEPEAPELVLDSGQHDREACKNQLIEFVKQKLS*" /label="cysC CDS" gene 1512971..1513564 /gene="cysC" /locus_tag="BSU_15600" /old_locus_tag="BSU15600" /label="cysC gene" S_feature 1513565..1513662 /Source="Nicolas_S_feature" /locus_tag="new_1633963_1634060" /HighExp="MG 10, B36, MG 5, MG t5, B60, MG 15, MG 90, MG-0.2, MG 60, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S570" CDS 1513663..1514436 /gene="sumT" /locus_tag="BSU_15610" /old_locus_tag="BSU15610" /EC_number="2.1.1.107" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1906874, 11004190, 10094622, 19154787; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III and precorrin-1 C-methyltransferase" /protein_id="NP_389444.1" /db_xref="EnsemblGenomes-Gn:BSU15610" /db_xref="EnsemblGenomes-Tr:CAB13435" /db_xref="GOA:O34744" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR003043" /db_xref="InterPro:IPR006366" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG13380" /db_xref="UniProtKB/Swiss-Prot:O34744" /translation="MGKVYIVGAGPGDPDLLTIKALKAIEKADVILYDRLVNKEILQY AKEQADLIYCGKLPDFHTMKQETINRFLVKYAQKGKMVVRLKGGDPFVFGRGGEEAEC LSENGIPFEIIPGITSGIAAAAYAGIPVTHRDAGSNVAFVTGHYKKEEDFEEKWKALA TGIDTLVIYMGIKNVQQIERKLLENGRDGSTPAAFIHWGTTDKQKSVFCTVDTLSETV IKENITNPSLIVIGNVVNYHYKLEWFESELKKQDLSEAL*" /label="sumT CDS" gene 1513663..1514436 /gene="sumT" /locus_tag="BSU_15610" /old_locus_tag="BSU15610" /label="sumT gene" promotor_-35 1514341..1514348 /Source="Nicolas_upshift_promotors" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1514363..1514382 /Source="Nicolas_upshift_promotors" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1514364 /Source="Nicolas_upshifts" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="upshifts" CDS 1514439..1515224 /gene="sirB" /locus_tag="BSU_15620" /old_locus_tag="BSU15620" /EC_number="4.99.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10094622, 11004190, 12408752; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sirohydrochlorin ferrochelatase" /protein_id="NP_389445.1" /db_xref="EnsemblGenomes-Gn:BSU15620" /db_xref="EnsemblGenomes-Tr:CAB13436" /db_xref="GOA:O34632" /db_xref="InterPro:IPR002762" /db_xref="SubtiList:BG13381" /db_xref="UniProtKB/Swiss-Prot:O34632" /translation="MKQAILYVGHGSRVKKAQQEAAAFLEGCKAHISVPVQEISFLEL QEPTIETGFEACVKQGATHIAVVPLLLLTAAHAKHDIPEEIVRVASRYPSVRISYGKP IGIDEEVVKAVYHRMKDIGVPYENARVVLIGRGSSDPDVKRDVTGIANLLQEMVPVKE VIPCFLTACGPNYKEVFSELEKDDGITTFIVPYLLFTGMLMNEIEREVQKLKAHNPNV YLSSYIGFHPHVKNAFLNRVRETAANSEGQFDFDGGSYASAAH*" /label="sirB CDS" gene 1514439..1515224 /gene="sirB" /locus_tag="BSU_15620" /old_locus_tag="BSU15620" /label="sirB gene" CDS 1515205..1515693 /gene="sirC" /locus_tag="BSU_15630" /old_locus_tag="BSU15630" /EC_number="1.3.1.76" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10094622, 11004190, 12408752, 18588505; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="precorrin-2 dehydrogenase" /protein_id="NP_389446.1" /db_xref="EnsemblGenomes-Gn:BSU15630" /db_xref="EnsemblGenomes-Tr:CAB13437" /db_xref="GOA:O34813" /db_xref="InterPro:IPR006367" /db_xref="InterPro:IPR028161" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13382" /db_xref="UniProtKB/Swiss-Prot:O34813" /translation="MLPLHISLEKKKVVIAGGGSIALRRLKTVISEGADITLVSPDVE PEIKQMAEERRIKWEKRTIEKEDYLNAFFIIAATDNAAVNKEIAQSASPFQLVNCVSD AELGNVYMPKIVKRGHVTVSVSTSGASPKHTKELAENVDKLIDGDFVAEVNRLYQMRR KK*" /label="sirC CDS" gene 1515205..1515693 /gene="sirC" /locus_tag="BSU_15630" /old_locus_tag="BSU15630" /label="sirC gene" downshifts 1515673 /Source="Nicolas_upshifts" /id="D875" /incds=0 /nref=256 /ntot=267 /MaxReadThrough="2.85828" /MaxDrop="8.90139" /score="26.5923498" /energy="-16.6" /TU="U1289" /idTUdmin="U1291" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1515720) /Source="Nicolas_upshifts" /id="D876" /incds=0 /nref=149 /ntot=238 /MaxReadThrough="1.71588" /MaxDrop="5.36964" /score="15.559144" /energy="-16.6" /TU="NA" /idTUdmin="U1292" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1515733..1517451) /gene="fbnA" /locus_tag="BSU_15640" /old_locus_tag="BSU15640" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11238985, 17586671, 24646681, 28294433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA modification protein" /protein_id="NP_389447.1" /db_xref="EnsemblGenomes-Gn:BSU15640" /db_xref="EnsemblGenomes-Tr:CAB13438" /db_xref="InterPro:IPR008532" /db_xref="SubtiList:BG13383" /db_xref="UniProtKB/Swiss-Prot:O34693" /translation="MHMSFDGMFTYGMTHELNEKIMGGRITKIHQPYKHDVIFHIRAK GKNQKLLLSAHPSYSRVHITAQAYENPSEPPMFCMLLRKHIEGGFIEKIEQAGLDRIM IFHIKSRNEIGDETVRKLYVEIMGRHSNIILTDAAENVIIDGLKHLSPSMNSYRTVLP GQDYKLPPAQDKISPLEASEDDILRHLSFQEGRLDKQIVDHFSGVSPLFAKEAVHRAG LANKVTLPKALLALFAEVKEHRFIPNITTVNGKEYFYLLELTHLKGEARRFDSLSELL DRFYFGKAERDRVKQQAQDLERFVVNERKKNANKIKKLEKTLEYSENAKEFQLYGELL TANLYMLKKGDKQAEVINYYDEESPTITIPLNPNKTPSENAQAYFTKYQKAKNSVAVV EEQIRLAQEEIEYFDQLIQQLSSASPRDISEIREELVEGKYLRPKQQKGQKKQKPHNP VLETYESTSGLTILVGKNNRQNEYLTTRVAARDDIWLHTKDIPGSHVVIRSSEPDEQT IMEAATIAAYFSKAKDSSSVPVDYTKIRHVKKPNGAKPGFVTYDSQHTVFVTPDADTV IKLKKS*" /label="fbnA CDS" gene complement(1515733..1517451) /gene="fbnA" /locus_tag="BSU_15640" /old_locus_tag="BSU15640" /label="fbnA gene" promotor_-10 complement(1517473..1517492) /Source="Nicolas_upshift_promotors" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1517487..1517492 /Source="Nicolas_upshift_promotors" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="promotor_-35" upshifts complement(1517487) /Source="Nicolas_upshifts" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1517505..1517510) /Source="Nicolas_upshift_promotors" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1517508..1517526 /Source="Nicolas_upshift_promotors" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="promotor_-10" upshifts 1517512 /Source="Nicolas_upshifts" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="upshifts" CDS 1517567..1520239 /gene="tcaB" /locus_tag="BSU_15650" /old_locus_tag="BSU15650" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12161109, 24415722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12161109, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="P-type calcium transport ATPase (sporulation)" /protein_id="NP_389448.1" /db_xref="EnsemblGenomes-Gn:BSU15650" /db_xref="EnsemblGenomes-Tr:CAB13439" /db_xref="GOA:O34431" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR004014" /db_xref="InterPro:IPR005782" /db_xref="InterPro:IPR006068" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG13384" /db_xref="UniProtKB/Swiss-Prot:O34431" /translation="MKFHEMGQTDLLEATNTSMKQGLTEKEVKKRLDKHGPNELQEGK KTSALLLFFAQFKDFMVLVLLAATLISGFLGEYVDAVAIIAIVFVNGILGFFQERRAE QSLQALKELSTPHVMALREGSWTKIPSKELVPGDIVKFTSGDRIGADVRIVEARSLEI EESALTGESIPVVKHADKLKKPDVSLGDITNMAFMGTIVTRGSGVGVVVGTGMNTAMG KIADMLESAGTLSTPLQRRLEQLGKILIVVALLLTVLVVAVGVIQGHDLYSMFLAGVS LAVAAIPEGLPAIVTVALSLGVQRMIKQKSIVRKLPAVETLGCASIICSDKTGTMTQN KMTVTHVWSGGKTWRVAGAGYEPKGSFTLNEKEISVNEHKPLQQMLLFGALCNNSNIE KRDGEYVLDGDPTEGALLTAARKGGFSKEFVESNYRVIEEFPFDSARKMMTVIVENQD RKRYIITKGAPDVLMQRSSRIYYDGSAALFSNERKAETEAVLRHLASQALRTIAVAYR PIKAGETPSMEQAEKDLTMLGLSGIIDPPRPEVRQAIKECREAGIKTVMITGDHVETA KAIAKDLRLLPKSGKIMDGKMLNELSQEELSHVVEDVYVFARVSPEHKLKIVKAYQEN GHIVAMTGDGVNDAPAIKQADIGVSMGITGTDVAKEASSLVLVDDNFATIKSAIKEGR NIYENIRKFIRYLLASNVGEILVMLFAMLLALPLPLVPIQILWVNLVTDGLPAMALGM DQPEGDVMKRKPRHPKEGVFARKLGWKVVSRGFLIGVATILAFIIVYHRNPENLAYAQ TIAFATLVLAQLIHVFDCRSETSVFSRNPFQNLYLIGAVLSSILLMLVVIYYPPLQPI FHTVAITPGDWMLVIGMSAIPTFLLAGSLLTRKK*" /label="tcaB CDS" gene 1517567..1520239 /gene="tcaB" /locus_tag="BSU_15650" /old_locus_tag="BSU15650" /label="tcaB gene" promotor_-10 complement(1518972..1518991) /Source="Nicolas_upshift_promotors" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1518983) /Source="Nicolas_upshifts" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1519006..1519013) /Source="Nicolas_upshift_promotors" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1520245..1520264 /Source="Nicolas_upshift_promotors" /id="U1295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.925074925074925" /psig="0.994005994005994" /xcortree=2170 /SigmaFactorBS="cgccatccctacttttttgctggcggggtcacttttaacaag aaaaaaataaattcaTATGATATAATCTTAGGGGTaatagcgtgtctattgccctttt a" /listShort="S571, yloC, ylzA, gmk, rpoZ, coaBC, priA, defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1520248..1520321 /Source="Nicolas_S_feature" /locus_tag="new_1640646_1640719" /HighExp="LPhT, LBGstat, T3.0H, H2O2, T3.30H, Salt, B60, Lbexp, UNK1, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.994, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S571" upshifts 1520248 /Source="Nicolas_upshifts" /id="U1295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.925074925074925" /psig="0.994005994005994" /xcortree=2170 /SigmaFactorBS="cgccatccctacttttttgctggcggggtcacttttaacaag aaaaaaataaattcaTATGATATAATCTTAGGGGTaatagcgtgtctattgccctttt a" /listShort="S571, yloC, ylzA, gmk, rpoZ, coaBC, priA, defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="upshifts" CDS 1520322..1521197 /gene="yloC" /locus_tag="BSU_15660" /old_locus_tag="BSU15660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389449.1" /db_xref="EnsemblGenomes-Gn:BSU15660" /db_xref="EnsemblGenomes-Tr:CAB13440" /db_xref="InterPro:IPR005229" /db_xref="InterPro:IPR013527" /db_xref="InterPro:IPR013551" /db_xref="SubtiList:BG13385" /db_xref="UniProtKB/Swiss-Prot:O34441" /translation="MIRSMTGFGSASKTQDDLSVSVELKSVNYRFKEVNARLPRPLLY FEDKLKQTILQHIQRGRIELFVSVDSDMLVEKRLEIDWPLLDEFVAAARDMKKRYQLS AEPDVMDFFKLDHVVQVHEEQTQNDKLEALIIDAAEEAVKGLCEMREKEGLLLAKDCL MHIDQLEELVRETELLAADVVSRYRERLYARIKEWTEDVLDESRLVTECAIFADRSDI TEEITRLKSHFAQFRDILASGGAVGRKLDFLVQELNREANTIGSKANDHQITKLVVEM KSSIEKIKEQVQNIE*" /label="yloC CDS" gene 1520322..1521197 /gene="yloC" /locus_tag="BSU_15660" /old_locus_tag="BSU15660" /label="yloC gene" CDS 1521274..1521543 /gene="remA" /locus_tag="BSU_15670" /old_locus_tag="BSU15670" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19363116, 23396918, 23646920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19363116, 23396918, 23646920; Product type r: regulator" /codon_start=1 /transl_table=11 /product="essential sporulation DNA binding protein; regulator of biofilm formation" /protein_id="NP_570902.1" /db_xref="EnsemblGenomes-Gn:BSU15670" /db_xref="EnsemblGenomes-Tr:CAE01452" /db_xref="InterPro:IPR007169" /db_xref="SubtiList:BG14185" /db_xref="UniProtKB/Swiss-Prot:Q7WY72" /translation="MTIKLINIGFGNIISANRMISIVSPESAPIKRMIQDARDRGMLI DATYGRRTRAVVVMDSDHIILSAVQPETVAHRLSVKEEIMDEGQG*" /label="remA CDS" gene 1521274..1521543 /gene="remA" /locus_tag="BSU_15670" /old_locus_tag="BSU15670" /label="remA gene" misc_feature complement(1521354..1521358) /Source="Nicolas_upshift_promotors" /id="U1296" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.889110889110889" /psig="0.001998001998002" /xcortree=58 /SigmaFactorBS="ccgtatgtagcgtcaattagcattccgcggtctcttgcatcc tgaatcatccgtttgattgGCGCAgactccgggctgacaatcgaaatcatccgattgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1521359) /Source="Nicolas_upshifts" /id="U1296" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.889110889110889" /psig="0.001998001998002" /xcortree=58 /SigmaFactorBS="ccgtatgtagcgtcaattagcattccgcggtctcttgcatcc tgaatcatccgtttgattgGCGCAgactccgggctgacaatcgaaatcatccgattgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1521551..1522165 /gene="gmk" /locus_tag="BSU_15680" /old_locus_tag="BSU15680" /EC_number="2.7.4.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17012781, 24722991" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17012781, 24722991; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="guanylate kinase" /protein_id="NP_389450.2" /db_xref="EnsemblGenomes-Gn:BSU15680" /db_xref="EnsemblGenomes-Tr:CAB13441" /db_xref="GOA:O34328" /db_xref="InterPro:IPR008144" /db_xref="InterPro:IPR008145" /db_xref="InterPro:IPR017665" /db_xref="InterPro:IPR020590" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13386" /db_xref="UniProtKB/Swiss-Prot:O34328" /translation="MKERGLLIVLSGPSGVGKGTVRQAIFSQEDTKFEYSISVTTRSP REGEVNGVDYFFKTRDEFEQMIADNKLLEWAEYVGNYYGTPVDYVEQTLQDGKDVFLE IEVQGALQVRNAFPEGLFIFLAPPSLSELKNRIVTRGTETDALIENRMKAAKAEIEMM DAYDYVVENDNVETACDKIKAIVLAEHLKRERVAPRYKKMLEVE*" /label="gmk CDS" gene 1521551..1522165 /gene="gmk" /locus_tag="BSU_15680" /old_locus_tag="BSU15680" /label="gmk gene" CDS 1522169..1522372 /gene="rpoZ" /locus_tag="BSU_15690" /old_locus_tag="BSU15690" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12089032, 16159791, 17233676, 24476911, 25878038; Product type f: factor" /codon_start=1 /transl_table=11 /product="omega subunit of RNA polymerase" /protein_id="NP_389451.1" /db_xref="EnsemblGenomes-Gn:BSU15690" /db_xref="EnsemblGenomes-Tr:CAB13442" /db_xref="GOA:O35011" /db_xref="InterPro:IPR003716" /db_xref="InterPro:IPR006110" /db_xref="InterPro:IPR012293" /db_xref="InterPro:IPR036161" /db_xref="SubtiList:BG13387" /db_xref="UniProtKB/Swiss-Prot:O35011" /translation="MLDPSIDSLMNKLDSKYTLVTVSARRAREMQIKKDQMIEHTISH KYVGKALEEIDAGLLSFEKEDRE*" /label="rpoZ CDS" gene 1522169..1522372 /gene="rpoZ" /locus_tag="BSU_15690" /old_locus_tag="BSU15690" /label="rpoZ gene" downshifts 1522361 /Source="Nicolas_upshifts" /id="D877" /incds=0 /nref=118 /ntot=257 /MaxReadThrough="5.65143" /MaxDrop="4.7291" /score="-8.13961715" /energy="-7.7" /TU="U1293,U1295" /idTUdmin="U1293" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" CDS 1522453..1523673 /gene="coaBC" /locus_tag="BSU_15700" /old_locus_tag="BSU15700" /EC_number="4.1.1.36" /EC_number="6.3.2.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11278255, 11358972, 12140293, 14686929, 15530362; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coenzyme A biosynthesis bifunctional protein CoaBC; phosphopantothenoylcysteine synthetase/decarboxylase" /protein_id="NP_389452.1" /db_xref="EnsemblGenomes-Gn:BSU15700" /db_xref="EnsemblGenomes-Tr:CAB13443" /db_xref="GOA:O35033" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR005252" /db_xref="InterPro:IPR007085" /db_xref="InterPro:IPR035929" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG13388" /db_xref="UniProtKB/Swiss-Prot:O35033" /translation="MLNNRNVLLCVSGGIAVYKACALTSKLVQAGANVKVIMTESACR FVSPLTFQALSRHEVYTDTFKEQNPSVISHIDAADWADLIIVAPATANVIGKLANGIA DDMLTTTLLAATAPVWIAPAMNVHMYDHPAVKRNISVLYQDGYCFIEPSEGYLACGYV GKGRLEEPENIVKLAEKHFAEETSAPLEGKHVVITAGPTREAIDPVRFFTNKSTGKMG YALAEAAVQLGARVILISGPVSLDQPKGLAEFIPVQSAADMREAVLSVYDASDIVIKT AAVADFTPKTVFDHKMKKQDGGMTLELKRTVDILKELGEKKKEQILVGFAAETQDIEH YARKKLAAKNLDLIVANDVKANGAGFGADTNIVTIFFKDGHKRELPIMSKLDVSFEIL QEIAALSKQTGERS*" /label="coaBC CDS" gene 1522453..1523673 /gene="coaBC" /locus_tag="BSU_15700" /old_locus_tag="BSU15700" /label="coaBC gene" S_feature complement(1523512..1524087) /Source="Nicolas_S_feature" /locus_tag="new_1643910_1644485_c" /HighExp="Etha, Salt, Sw, Gly, C30, M9-stat, B60, LPhT, HiTm, Heat" /AntisenseName="priA" /AntisenseCor="-5.1213364637925501E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S572" CDS 1523670..1526087 /gene="priA" /locus_tag="BSU_15710" /old_locus_tag="BSU15710" /function="16.9: Replicate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10572298, 11917020, 12682299, 21170359, 22720735, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572298, 11917020, 12682299, 21170359, 22720735, 28527403; Product type f : factor" /codon_start=1 /transl_table=11 /product="primosomal replication factor Y (primosomal protein N')" /protein_id="NP_389453.1" /db_xref="EnsemblGenomes-Gn:BSU15710" /db_xref="EnsemblGenomes-Tr:CAB13444" /db_xref="GOA:P94461" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR005259" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11963" /db_xref="UniProtKB/Swiss-Prot:P94461" /translation="MNFAEVIVDVSTKNIDRPFDYKIPDHLKGMIKTGMRVIVPFGPR KIQGFVTAVKEASDLSGKSVKEVEDLLDLTPVLTEELMILSSWLSDKTLSFKITALQA MLPAALKAKYEKELKIAHGADLPPQVERLFSETKTLLYSDIPDHETLKLIQRHVQKGD IDVTYKVAQKTNKKMVRHIQANASKEELAKQAEGLSRQAAKQQAILHFLISEPEGVKI PAAELCKKTDTSSATIKTLIQKGLLKESYEEVYRDPYQDKMFKKTEPLPLTDEQRAAF EPIRETLDSDEHKVFLLHGVTGSGKTEIYLQSIEKVLAKGKEAIVLVPEISLTPQMVN RFKGRFGSQVAVMHSGLSTGEKYDEWRKIHRKEVRLVVGARSAIFAPFENLGMIIIDE EHESSYKQEEMPRYHAKEVAIKRAEHHSCPVVLGSATPTLESYARAQKGVYELLSLKH RVNHRVMPEVSLVDMREELRNGNRSMFSVELMEKLEETIAKGEQAVLFLNKRGYSSFV MCRDCGYVPQCPHCDISMTYHRYGQRLKCHYCGHEEPVPHTCPECASEHIRFFGTGTQ RVEEELTKVLPSARVIRMDVDTTSRKGAHEKLLSAFGEGKADILLGTQMIAKGLDFPN VTLVGVLSADTTLHIPDFRSAEKTFQLLTQVSGRAGRHEKPGHVIIQTYTPSHYSIQL TKTHDYETFYQHEMAHRREQSYPPYYYLALVTVSHEEVAKAAVTAEKIAHFLKANCGA DTKILGPSASPIARIKDRYRYQCVIKYKQETQLSALLKKILEHYKREIEQKHVMISID MNPYMMM*" /label="priA CDS" gene 1523670..1526087 /gene="priA" /locus_tag="BSU_15710" /old_locus_tag="BSU15710" /label="priA gene" promotor_-10 complement(1524083..1524101) /Source="Nicolas_upshift_promotors" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1524087) /Source="Nicolas_upshifts" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1524115..1524121) /Source="Nicolas_upshift_promotors" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1525938..1525942 /Source="Nicolas_upshift_promotors" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1525958..1525977 /Source="Nicolas_upshift_promotors" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1525969 /Source="Nicolas_upshifts" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="upshifts" CDS 1526114..1526596 /gene="defA" /locus_tag="BSU_15720" /old_locus_tag="BSU15720" /EC_number="3.5.1.88" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11429456, 16014871, 16207374" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11429456, 16014871, 16207374; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide deformylase" /protein_id="NP_389454.1" /db_xref="EnsemblGenomes-Gn:BSU15720" /db_xref="EnsemblGenomes-Tr:CAB13445" /db_xref="GOA:P94462" /db_xref="InterPro:IPR023635" /db_xref="InterPro:IPR036821" /db_xref="SubtiList:BG11933" /db_xref="UniProtKB/Swiss-Prot:P94462" /translation="MAVKKVVTHPAEVLETPAETVTVFDKKLKKLLDDMYDTMLEMDG VGLAAPQIGILKRAAVVEIGDDRGRIDLVNPEILEKSGEQTGIEGCLSFPNVYGDVTR ADYVKVRAFNRQGKPFILEARGFLARAVQHEMDHLDGVLFTSKISKYYTEDELADMEG *" /label="defA CDS" gene 1526114..1526596 /gene="defA" /locus_tag="BSU_15720" /old_locus_tag="BSU15720" /label="defA gene" CDS 1526601..1527554 /gene="fmt" /locus_tag="BSU_15730" /old_locus_tag="BSU15730" /EC_number="2.1.2.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:769821, 769822, 98518, 9843487, 10858337, 26888283, 27983482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 769821, 769822, 98518, 9843487, 10858337, 26888283, 27983482; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="methionyl-tRNA formyltransferase" /protein_id="NP_389455.1" /db_xref="EnsemblGenomes-Gn:BSU15730" /db_xref="EnsemblGenomes-Tr:CAB13446" /db_xref="GOA:P94463" /db_xref="InterPro:IPR001555" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR005793" /db_xref="InterPro:IPR005794" /db_xref="InterPro:IPR011034" /db_xref="InterPro:IPR036477" /db_xref="InterPro:IPR037022" /db_xref="SubtiList:BG11937" /db_xref="UniProtKB/Swiss-Prot:P94463" /translation="MTRIVFMGTPDFSVPVLRTLIEDGYEVVGVVTQPDRPKGRKKVL TPPPVKEEALRHGIPVLQPEKVRLTEEIEKVLALKPDLIVTAAFGQILPKELLDSPKY GCINVHASLLPELRGGAPIHYSILQGKKKTGITIMYMVEKLDAGDMISKVEVDIEETD NVGTLHDKLSVAGAKLLSETVPNVIAGSISPEKQDEEKATYAPNIKREQELLDWSRTG EELYNQIRGLNPWPVAYTTLNGQNLKIWASKKIAAPTTAEPGTVVAVEKEGIIVATGN ETALLLTELQPAGKKRMKGEDFVRGAHVEAGDVLGVNNEKN*" /label="fmt CDS" gene 1526601..1527554 /gene="fmt" /locus_tag="BSU_15730" /old_locus_tag="BSU15730" /label="fmt gene" CDS 1527541..1528884 /gene="rsmB" /locus_tag="BSU_15740" /old_locus_tag="BSU15740" /EC_number="2.1.1.176" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14656444, 23729652, 27698115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="RNA-binding Sun protein; 16S rRNA m5C967 methyltransferase, S-adenosyl-L-methionine-dependent" /protein_id="NP_389456.1" /db_xref="EnsemblGenomes-Gn:BSU15740" /db_xref="EnsemblGenomes-Tr:CAB13447" /db_xref="GOA:P94464" /db_xref="InterPro:IPR001678" /db_xref="InterPro:IPR004573" /db_xref="InterPro:IPR006027" /db_xref="InterPro:IPR018314" /db_xref="InterPro:IPR023267" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR035926" /db_xref="SubtiList:BG12253" /db_xref="UniProtKB/Swiss-Prot:P94464" /translation="MKKTSVRDIALEALIKLEQNQAYSNLLLKSVIKSNELSDQNRGL LTELVYGTLQNKIALDYMLKPFINKPQKVKPWVIQLLRLSLYQMEYLEKIPDRAAIHE AVEIAKIRGHKGIASFVNGVLRSIQREGVPSFDAIEDPVRRLATETSHPEWLVKEWAD AYGFEAAEKICRIHLIPPKQTLRVNQMKADRAELLDQMAAEGIEVEKGDLAEDAVKLL KGTIAGTHFFQNGEVSIQDESSMLVARALDPKSDETVLDACAAPGGKSAHIAELMKNK GSVTSLDLHKHKVKLIKEAADRLGLTIIHAETMDARKAGETFENEQFDRILVDAPCSG FGVIRRKPDMKYTKKPDDSARLAEIQLSILREIAPLVKKGGTLVYSTCTMDRTENDEV IHAFIQEHPDFEPDLSLEKRLPEKVRPFVRDGRLQILPHYFGTDGFFICSMRKKG*" /label="rsmB CDS" gene 1527541..1528884 /gene="rsmB" /locus_tag="BSU_15740" /old_locus_tag="BSU15740" /label="rsmB gene" CDS 1528888..1529979 /gene="rlmN" /locus_tag="BSU_15750" /old_locus_tag="BSU15750" /EC_number="2.1.1.192" /function="10.3: tRNA and rRNA base modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8973346, 18307109, 20184321, 21368151, 22891362, 27081063, 27902775; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m2A2503 methyltransferase and tRNA A37 C2 methyltransferase" /protein_id="NP_389457.1" /db_xref="EnsemblGenomes-Gn:BSU15750" /db_xref="EnsemblGenomes-Tr:CAB13448" /db_xref="GOA:O34617" /db_xref="InterPro:IPR004383" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR027492" /db_xref="SubtiList:BG13389" /db_xref="UniProtKB/Swiss-Prot:O34617" /translation="MAELNKTKVRKELRTERPSIYSFELDEIKQWLTDNGEKPFRAAQ IFEWLYEKRVSSFEDMTNLSKDLREKLNTRFVLTTLKTAVKQTSQDGTMKFLFELHDG YTIETVLMRHEYGNSVCVTTQVGCRIGCTFCASTLGGLKRNLEAGEIVAQVVKVQKAL DETDERVSSVVIMGIGEPFDNFNEMLAFLKIINHDKGLNIGARHITVSTSGIIPKIYE FADQQMQINFAISLHAPNTEIRSRLMPINRAYKLPDLMEAVKYYINKTGRRISFEYGL FGGVNDQVEHAEELADLLEGVKCHVNLIPVNYVPERDYVRTPRDQIFAFEKTLKSRGV NVTIRREQGHDIDAACGQLRAKERQDETR*" /label="rlmN CDS" gene 1528888..1529979 /gene="rlmN" /locus_tag="BSU_15750" /old_locus_tag="BSU15750" /label="rlmN gene" CDS 1529986..1530750 /gene="prpC" /locus_tag="BSU_15760" /old_locus_tag="BSU15760" /EC_number="3.1.3.16" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10986276, 12399479, 17693724, 22720735, 24390483, 25012659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986276, 12399479, 17693724, 22720735, 24390483, 25012659; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="multitarget phosphorylated protein phosphatase" /protein_id="NP_389458.1" /db_xref="EnsemblGenomes-Gn:BSU15760" /db_xref="EnsemblGenomes-Tr:CAB13449" /db_xref="GOA:O34779" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR015655" /db_xref="InterPro:IPR036457" /db_xref="SubtiList:BG13390" /db_xref="UniProtKB/Swiss-Prot:O34779" /translation="MLTALKTDTGKIRQHNEDDAGIFKGKDEFILAVVADGMGGHLAG DVASKMAVKAMGEKWNEAETIPTAPSECEKWLIEQILSVNSKIYDHAQAHEECQGMGT TIVCALFTGKTVSVAHIGDSRCYLLQDDDFVQVTEDHSLVNELVRTGEISREDAEHHP RKNVLTKALGTDQLVSIDTRSFDIEPGDKLLLCSDGLTNKVEGTELKDILQSDSAPQE KVNLLVDKANQNGGEDNITAVLLELALQVEEGEDQC*" /label="prpC CDS" gene 1529986..1530750 /gene="prpC" /locus_tag="BSU_15760" /old_locus_tag="BSU15760" /label="prpC gene" downshifts 1530039 /Source="Nicolas_upshifts" /id="D878" /incds=0 /nref=5 /ntot=126 /MaxReadThrough="6.12318" /MaxDrop="3.8594" /score="-7.80200272" /energy="-10" /TU="U1295,U1298" /idTUdmin="U1300" /TUdmin="-4708" /isTUend="FALSE" /label="downshifts" CDS 1530744..1532690 /gene="prkC" /locus_tag="BSU_15770" /old_locus_tag="BSU15770" /EC_number="2.7.11.1" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10986276, 12399479, 18984160, 24390483, 25845974, 26102633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986276, 12399479, 18984160, 24390483, 25845974, 26102633; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein serine/threonine kinase" /protein_id="NP_389459.1" /db_xref="EnsemblGenomes-Gn:BSU15770" /db_xref="EnsemblGenomes-Tr:CAB13450" /db_xref="GOA:O34507" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR008271" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG13391" /db_xref="UniProtKB/Swiss-Prot:O34507" /translation="MLIGKRISGRYQILRVIGGGGMANVYLAEDIILDREVAIKILRF DYANDNEFIRRFRREAQSASSLDHPNIVSIYDLGEEDDIYYIVMEYVEGMTLKEYITA NGPLHPKEALNIMEQIVSAIAHAHQNQIVHRDIKPHNILIDHMGNIKVTDFGIATALS STTITHTNSVLGSVHYLSPEQARGGLATKKSDIYALGIVLFELLTGRIPFDGESAVSI ALKHLQAETPSAKRWNPSVPQSVENIILKATAKDPFHRYETAEDMEADIKTAFDADRL NEKRFTIQEDEEMTKAIPIIKDEELAKAAGEKEAEVTTAQENKTKKNGKRKKWPWVLL TICLVFITAGILAVTVFPSLFMPKDVKIPDVSGMEYEKAAGLLEKEGLQVDSEVLEIS DEKIEEGLMVKTDPKADTTVKEGATVTLYKSTGKAKTEIGDVTGQTVDQAKKALKDQG FNHVTVNEVNDEKNAGTVIDQNPSAGTELVPSEDQVKLTVSIGPEDITLRDLKTYSKE AASGYLEDNGLKLVEKEAYSDDVPEGQVVKQKPAAGTAVKPGNEVEVTFSLGPEKKPA KTVKEKVKIPYEPENEGDELQVQIAVDDADHSISDTYEEFKIKEPTERTIELKIEPGQ KGYYQVMVNNKVVSYKTIEYPKDE*" /label="prkC CDS" gene 1530744..1532690 /gene="prkC" /locus_tag="BSU_15770" /old_locus_tag="BSU15770" /label="prkC gene" promotor_-35 1532599..1532605 /Source="Nicolas_upshift_promotors" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1532619..1532637 /Source="Nicolas_upshift_promotors" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1532635 /Source="Nicolas_upshifts" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="upshifts" CDS 1532705..1533601 /gene="rsgA" /locus_tag="BSU_15780" /old_locus_tag="BSU15780" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15223319, 15828870, 16014871, 16485133, 17005971, 18007041, 18344364, 19246764, 22544754, 22720735, 28482099" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15223319, 15828870, 16014871, 16485133, 17005971, 18007041, 18344364, 19246764, 22544754, 22720735, 28482099; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="GTPase involved in ribosome biogenesis" /protein_id="NP_389460.1" /db_xref="EnsemblGenomes-Gn:BSU15780" /db_xref="EnsemblGenomes-Tr:CAB13451" /db_xref="GOA:O34530" /db_xref="InterPro:IPR004881" /db_xref="InterPro:IPR010914" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="InterPro:IPR031944" /db_xref="PDB:1T9H" /db_xref="SubtiList:BG13392" /db_xref="UniProtKB/Swiss-Prot:O34530" /translation="MPEGKIIKALSGFYYVLDESEDSDKVIQCRGRGIFRKNKITPLV GDYVVYQAENDKEGYLMEIKERTNELIRPPICNVDQAVLVFSAVQPSFSTALLDRFLV LVEANDIQPIICITKMDLIEDQDTEDTIQAYAEDYRNIGYDVYLTSSKDQDSLADIIP HFQDKTTVFAGQSGVGKSSLLNAISPELGLRTNEISEHLGRGKHTTRHVELIHTSGGL VADTPGFSSLEFTDIEEEELGYTFPDIREKSSSCKFRGCLHLKEPKCAVKQAVEDGEL KQYRYDHYVEFMTEIKDRKPRY*" /label="rsgA CDS" gene 1532705..1533601 /gene="rsgA" /locus_tag="BSU_15780" /old_locus_tag="BSU15780" /label="rsgA gene" CDS 1533606..1534259 /gene="rpe" /locus_tag="BSU_15790" /old_locus_tag="BSU15790" /EC_number="5.1.3.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 973353, 15755726, 16489742, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribulose-5-phosphate 3-epimerase" /protein_id="NP_389461.1" /db_xref="EnsemblGenomes-Gn:BSU15790" /db_xref="EnsemblGenomes-Tr:CAB13452" /db_xref="GOA:O34557" /db_xref="InterPro:IPR000056" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR026019" /db_xref="SubtiList:BG13393" /db_xref="UniProtKB/Swiss-Prot:O34557" /translation="MIKVAPSILSADFAALGNEIKDVEKGGADCIHIDVMDGHFVPNI TIGPLIVEAVRPVTDLPLDVHLMIEEPDRYIPAFAKAGADILSVHAEACPHLHRTIQL IKEQGVKAGVVLNPHTPVQVIEHVFDDLDLVLLMTVNPGFGGQKFIHSVLPKIKEVKR MADEKGKKDLLIEVDGGVNKETAPLVIEAGANLLVAGSAVYGQSDRKKAISEIRGSK* " /label="rpe CDS" gene 1533606..1534259 /gene="rpe" /locus_tag="BSU_15790" /old_locus_tag="BSU15790" /label="rpe gene" promotor_-35 1534257..1534266 /Source="Nicolas_upshift_promotors" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="promotor_-35" promotor_-10 1534280..1534299 /Source="Nicolas_upshift_promotors" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="promotor_-10" upshifts 1534285 /Source="Nicolas_upshifts" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="upshifts" CDS 1534332..1534976 /gene="thiN" /locus_tag="BSU_15800" /old_locus_tag="BSU15800" /EC_number="2.7.6.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14567704, 15150256, 16291685, 19490098; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine pyrophosphokinase" /protein_id="NP_389462.1" /db_xref="EnsemblGenomes-Gn:BSU15800" /db_xref="EnsemblGenomes-Tr:CAB13453" /db_xref="GOA:O34664" /db_xref="InterPro:IPR006282" /db_xref="InterPro:IPR007371" /db_xref="InterPro:IPR007373" /db_xref="InterPro:IPR036371" /db_xref="InterPro:IPR036759" /db_xref="PDB:3LM8" /db_xref="SubtiList:BG13394" /db_xref="UniProtKB/Swiss-Prot:O34664" /translation="MKTINIVAGGPKNLIPDLTGYTDEHTLWIGVDKGTVTLLDAGII PVEAFGDFDSITEQERRRIEKAAPALHVYQAEKDQTDLDLALDWALEKQPDIIQIFGI TGGRADHFLGNIQLLYKGVKTNIKIRLIDKQNHIQMFPPGEYDIEKDENKRYISFIPF SEDIHELTLTGFKYPLNNCHITLGSTLCISNELIHSRGTFSFAKGILIMIRSTD*" /label="thiN CDS" gene 1534332..1534976 /gene="thiN" /locus_tag="BSU_15800" /old_locus_tag="BSU15800" /label="thiN gene" promotor_-35 1534737..1534743 /Source="Nicolas_upshift_promotors" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="promotor_-35" upshifts 1534754 /Source="Nicolas_upshifts" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="upshifts" promotor_-10 1534758..1534776 /Source="Nicolas_upshift_promotors" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="promotor_-10" promotor_-35 1534867..1534872 /Source="Nicolas_upshift_promotors" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1534888..1534906 /Source="Nicolas_upshift_promotors" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1534901 /Source="Nicolas_upshifts" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="upshifts" S_feature 1534977..1535047 /Source="Nicolas_S_feature" /locus_tag="new_1655375_1655445" /HighExp="S4, S5, S7, S8, S6, S3, B36, G/S, B60, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigB, SigA, SigA" /TUshortPSig="0.977, 0.548, 0.973, 1, 0.994" /TUlongSig="SigK" /TUlongPSig="0.951" /label="S573" CDS 1535048..1535128 /gene="spoVM" /locus_tag="BSU_15810" /old_locus_tag="BSU15810" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9922240, 10077851, 10913836, 12562810, 18820968, 25825747, 28408070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9922240, 10077851, 10913836, 12562810, 18820968, 25825747, 28408070; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for normal spore cortex and coatsynthesis (stage V sporulation)" /protein_id="NP_389463.1" /db_xref="EnsemblGenomes-Gn:BSU15810" /db_xref="EnsemblGenomes-Tr:CAB13454" /db_xref="GOA:P37817" /db_xref="InterPro:IPR012609" /db_xref="PDB:2MVH" /db_xref="PDB:2MVJ" /db_xref="SubtiList:BG10776" /db_xref="UniProtKB/Swiss-Prot:P37817" /translation="MKFYTIKLPKFLGGIVRAMLGSFRKD*" /label="spoVM CDS" gene 1535048..1535128 /gene="spoVM" /locus_tag="BSU_15810" /old_locus_tag="BSU15810" /label="spoVM gene" downshifts 1535143 /Source="Nicolas_upshifts" /id="D879" /incds=0 /nref=178 /ntot=258 /MaxReadThrough="4.05442" /MaxDrop="7.745" /score="7.47691609" /energy="-16.9" /TU="U1301,U1302" /idTUdmin="U1295" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1535188..1535560 /Source="Nicolas_S_feature" /locus_tag="new_1655586_1655958" /HighExp="S4, S5, T5.0H, S3, S6, S8, S7, T4.0H, LoTm, T3.30H" /AntisenseName="rpmB" /AntisenseCor="-0.40376097579549802" /AntisenseRegPval="-11.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.977, 0.548" /TUlongSig="SigK" /TUlongPSig="0.951" /label="S574" CDS complement(1535201..1535389) /gene="rpmB" /locus_tag="BSU_15820" /old_locus_tag="BSU15820" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8722036; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L28" /protein_id="NP_389464.1" /db_xref="EnsemblGenomes-Gn:BSU15820" /db_xref="EnsemblGenomes-Tr:CAB13455" /db_xref="GOA:P37807" /db_xref="InterPro:IPR001383" /db_xref="InterPro:IPR026569" /db_xref="InterPro:IPR034704" /db_xref="InterPro:IPR037147" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10777" /db_xref="UniProtKB/Swiss-Prot:P37807" /translation="MARKCVITGKKTTAGNNRSHAMNASKRTWGANLQKVRILVNGKP KKVYVSARALKSGKVERV*" /label="rpmB CDS" gene complement(1535201..1535389) /gene="rpmB" /locus_tag="BSU_15820" /old_locus_tag="BSU15820" /label="rpmB gene" downshifts complement(1535217) /Source="Nicolas_upshifts" /id="D880" /incds=0 /nref=216 /ntot=298 /MaxReadThrough="2.59598" /MaxDrop="7.48719" /score="15.2403969" /energy="-14.3" /TU="NA" /idTUdmin="U1303" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" downshifts complement(1535263) /Source="Nicolas_upshifts" /id="D881" /incds=1 /nref=1 /ntot=18 /MaxReadThrough="7.6779" /MaxDrop="3.1786" /score="15.2403969" /energy="-14.3" /TU="U1303" /idTUdmin="U1303" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(1535390..1535482) /Source="Nicolas_S_feature" /locus_tag="new_1655788_1655880_c" /HighExp="HPh, LPh, HiOs, LBGexp, aero, G180, GM 15, dia0, MG 25, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S575" promotor_-10 complement(1535464..1535483) /Source="Nicolas_upshift_promotors" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1535482) /Source="Nicolas_upshifts" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1535499..1535502) /Source="Nicolas_upshift_promotors" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1535533..1535540 /Source="Nicolas_upshift_promotors" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-35" promotor_-10 1535555..1535573 /Source="Nicolas_upshift_promotors" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-10" upshifts 1535562 /Source="Nicolas_upshifts" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="upshifts" promotor_-35 1535601..1535604 /Source="Nicolas_upshift_promotors" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-35" promotor_-10 1535619..1535638 /Source="Nicolas_upshift_promotors" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-10" upshifts 1535627 /Source="Nicolas_upshifts" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="upshifts" CDS 1535666..1536028 /gene="yloU" /locus_tag="BSU_15830" /old_locus_tag="BSU15830" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 17114254, 24178028, 28579978; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor involved in malonyl-CoA synthesis" /protein_id="NP_389465.1" /db_xref="EnsemblGenomes-Gn:BSU15830" /db_xref="EnsemblGenomes-Tr:CAB13456" /db_xref="InterPro:IPR005531" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG13395" /db_xref="UniProtKB/Swiss-Prot:O34318" /translation="MSIELRTKYGQIDISNEVIAMVAGGAAVDCYGIVGMASKNQIKD GLTEILRKENFSRGVQVRQEGEQIHIDMYIIVSYGTKISEVAHNVQTKVKYTVNQTIG LAVDSVNIYVQGVRVTNP*" /label="yloU CDS" gene 1535666..1536028 /gene="yloU" /locus_tag="BSU_15830" /old_locus_tag="BSU15830" /label="yloU gene" downshifts complement(1535879) /Source="Nicolas_upshifts" /id="D882" /incds=1 /nref=1 /ntot=143 /MaxReadThrough="1.75412" /MaxDrop="2.71497" /score="15.2403969" /energy="-14.3" /TU="NA" /idTUdmin="U1303" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" CDS 1536044..1537705 /gene="yloV" /locus_tag="BSU_15840" /old_locus_tag="BSU15840" /EC_number="2.7.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16647083, 22333191, 22517742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme structurally related to dihydroxyacetone/glyceraldehyde kinase" /protein_id="NP_389466.1" /db_xref="EnsemblGenomes-Gn:BSU15840" /db_xref="EnsemblGenomes-Tr:CAB13457" /db_xref="GOA:O34751" /db_xref="InterPro:IPR004007" /db_xref="InterPro:IPR019986" /db_xref="InterPro:IPR033470" /db_xref="InterPro:IPR036117" /db_xref="SubtiList:BG13396" /db_xref="UniProtKB/Swiss-Prot:O34751" /translation="MSIRTLDGRTFAEMILAGAQNLSQNASAVDALNVFPVPDGDTGT NMNLSMTSGAREVEQMDTDDIGKVGSALSKGLLMGARGNSGVILSQLFRGFSKNIETK KEINALEFAAALQAGVDMAYKAVMKPVEGTILTVAKDAAKKAMILAEKETDITALMTA VTEEAEASLNRTPELLPVLKEVGVVDSGGKGLLCVYEGFLASLKGETVPQKAVLPSLD DMVSAEHHKSAQSMMNTEDIEFGFCTEVMVRLDQTKREFDEGTFRQDLSQFGDSLLVI ADESLAKVHIHAEEPGNVLNYAQHYGELIKIKIENMREQHTSIISQESKPADNETPPA KQPYGIVTVAMGEGIADLFKSIGASVVIEGGQTMNPSTEDIVDAVKSVNADTVFILPN NSNIIMAANQAASVVDEQVFVIPAKTVPQGMSALLAFNPDQEAEANEANMLSAIQQVK SGQVTFSVRDTHIDGKDIKKGDFMGILNGTIIGTSENQLSAAKMLLSEMIGEDDEIVT ILYGEDASQEEAEQLEAFLSEKYEEIEVEIHNGKQPLYSYIVSAE*" /label="yloV CDS" gene 1536044..1537705 /gene="yloV" /locus_tag="BSU_15840" /old_locus_tag="BSU15840" /label="yloV gene" S_feature 1537706..1537795 /Source="Nicolas_S_feature" /locus_tag="new_1658104_1658193" /HighExp="G135, G180, G150, LBGexp, Oxctl, Paraq, dia0, LPh, Lbexp, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37023200000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.991, 0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S576" promotor_-35 1537768..1537775 /Source="Nicolas_upshift_promotors" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="promotor_-35" promotor_-10 1537789..1537808 /Source="Nicolas_upshift_promotors" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="promotor_-10" upshifts 1537797 /Source="Nicolas_upshifts" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="upshifts" CDS 1537844..1538506 /gene="sdaAB" /locus_tag="BSU_15850" /old_locus_tag="BSU15850" /EC_number="4.3.1.17" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8385012, 9244285, 16014871, 22686449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8385012, 9244285, 16014871, 22686449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-serine dehydratase (beta chain)" /protein_id="NP_389467.1" /db_xref="EnsemblGenomes-Gn:BSU15850" /db_xref="EnsemblGenomes-Tr:CAB13458" /db_xref="GOA:O34635" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004643" /db_xref="InterPro:IPR005131" /db_xref="InterPro:IPR029009" /db_xref="SubtiList:BG13397" /db_xref="UniProtKB/Swiss-Prot:O34635" /translation="MKYRSVFDIIGPVMIGPSSSHTAGAARIGRVARSLFGREPERII VSFYGSFAETYKGHGTDVAIIGGLLDFDTFDERIKTAIQIAEAKGIDIEFRVEDAVPV HPNTAKITISDEKGELELTGISIGGGKIEITELNGFELRLSGNHPAILVVHNDKFGTI AGVANVLAKFSINVGHMEVARKDIGQLALMTIEVDQNIDDHILDELSKLPNIIQVTKI AD*" /label="sdaAB CDS" gene 1537844..1538506 /gene="sdaAB" /locus_tag="BSU_15850" /old_locus_tag="BSU15850" /label="sdaAB gene" CDS 1538532..1539434 /gene="sdaAA" /locus_tag="BSU_15860" /old_locus_tag="BSU15860" /EC_number="4.3.1.17" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2504697, 16014871, 22686449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2504697, 16014871, 22686449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-serine dehydratase (alpha chain)" /protein_id="NP_389468.1" /db_xref="EnsemblGenomes-Gn:BSU15860" /db_xref="EnsemblGenomes-Tr:CAB13459" /db_xref="GOA:O34607" /db_xref="InterPro:IPR004642" /db_xref="InterPro:IPR005130" /db_xref="SubtiList:BG13398" /db_xref="UniProtKB/Swiss-Prot:O34607" /translation="MFRNVKELIEITKEKQILISDVMIAQEMEVTEKTKEDIFQQMDH NLSVMEAAVQKGLEGVTSQTGLTGGDAVKLQAYIRSGKSLSGPLILDAVSKAVATNEV NAAMGTICATPTAGSAGVVPGTLFAVKEKLNPTREQMIRFLFTAGAFGFVVANNASIS GAAGGCQAEVGSASGMAAAAIVEMAGGTPEQSAEAMAITLKNMLGLVCDPVAGLVEVP CVKRNAMGASNAMIAADMALAGITSRIPCDEVIDAMYKIGQTMPTALRETGQGGLAAT PTGRELEKKIFGGALGSRETTSAN*" /label="sdaAA CDS" gene 1538532..1539434 /gene="sdaAA" /locus_tag="BSU_15860" /old_locus_tag="BSU15860" /label="sdaAA gene" CDS 1539412..1541460 /gene="recG" /locus_tag="BSU_15870" /old_locus_tag="BSU15870" /EC_number="3.6.4.12" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:1905712, 1494351, 15317759, 15533834, 16014871, 28078722, 28155219, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1905712, 1494351, 15317759, 15533834, 16014871, 28078722, 28155219, 28527403; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branch migrating ATP-dependent DNA helicase involved in DNA recombination and repair" /protein_id="NP_389469.1" /db_xref="EnsemblGenomes-Gn:BSU15870" /db_xref="EnsemblGenomes-Tr:CAB13460" /db_xref="GOA:O34942" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR004609" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033454" /db_xref="SubtiList:BG13399" /db_xref="UniProtKB/Swiss-Prot:O34942" /translation="MKQHQQTSIANIKGIGPETEKTLNELGIYDISDLLNYFPYRYDD YELRDLEEVKHDERVTVEGKVHSEPSLTYYGKKRNRLTFRLLVGHYLITAVCFNRPYL KKKLSLGSVVTVSGKWDKHRQTISVQELKNGPHQEDKSIEPVYSVKENVTVKMMRRFI QQALTQYADSLPDPLPEKLRKSYKLPDYYQALKAMHQPETREALKLARRRFVYEEFLL FQLKMQAFRKAEREQTQGIRQRFSNEELMRFIKSLPFPLTNAQSRVLREITADMSSPY RMNRLLQGDVGSGKTAVAAIALYAAILSGYQGALMVPTEILAEQHADSLVSLFEKWDV SVALLTSSVKGKRRKELLERLAAGEIDILVGTHALIQDEVEFKALSLVITDEQHRFGV EQRKKLRNKGQDPDVLFMTATPIPRTLAITVFGEMDVSVIDEMPAGRKRIETYWVKHD MLDRILAFVEKELKQGRQAYIICPLIEESDKLDVQNAIDVYNMLSDIFRGKWNVGLMH GKLHSDEKDQVMREFSANHCQILVSTTVVEVGVNVPNATIMVIYDADRFGLSQLHQLR GRVGRGEHQSFCILMADPKSETGKERMRIMSETNDGFELSEKDLELRGPGDFFGKKQS GMPEFKVADMVHDYRALETARQDAANLVASDAFWKEPEYAVLRDELLKSGVMDGEKLS *" /label="recG CDS" gene 1539412..1541460 /gene="recG" /locus_tag="BSU_15870" /old_locus_tag="BSU15870" /label="recG gene" promotor_-35 1541496..1541503 /Source="Nicolas_upshift_promotors" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1541518..1541537 /Source="Nicolas_upshift_promotors" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1541524 /Source="Nicolas_upshifts" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1541569..1542135 /gene="fapR" /locus_tag="BSU_15880" /old_locus_tag="BSU15880" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12737802, 17962296, 20201588, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12737802, 17962296, 20201588, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcription factor controlling fatty acid and phospholipid metabolism (FapR-malonyl-Coa)" /protein_id="NP_389470.1" /db_xref="EnsemblGenomes-Gn:BSU15880" /db_xref="EnsemblGenomes-Tr:CAB13461" /db_xref="GOA:O34835" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR017275" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR036388" /db_xref="PDB:2F3X" /db_xref="PDB:2F41" /db_xref="SubtiList:BG13400" /db_xref="UniProtKB/Swiss-Prot:O34835" /translation="MRRNKRERQELLQQTIQATPFITDEELAGKFGVSIQTIRLDRLE LSIPELRERIKNVAEKTLEDEVKSLSLDEVIGEIIDLELDDQAISILEIKQEHVFSRN QIARGHHLFAQANSLAVAVIDDELALTASADIRFTRQVKQGERVVAKAKVTAVEKEKG RTVVEVNSYVGEEIVFSGRFDMYRSKHS*" /label="fapR CDS" gene 1541569..1542135 /gene="fapR" /locus_tag="BSU_15880" /old_locus_tag="BSU15880" /label="fapR gene" CDS 1542149..1543150 /gene="plsX" /locus_tag="BSU_15890" /old_locus_tag="BSU15890" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12682299, 16949372, 17557823, 17645809, 18369234, 19282621, 19850612, 24224907, 26816052, 26850107" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12682299, 16949372, 17557823, 17645809, 18369234, 19282621, 19850612, 24224907, 26816052, 26850107; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphate:acyl-ACP acyltransferase" /protein_id="NP_389471.1" /db_xref="EnsemblGenomes-Gn:BSU15890" /db_xref="EnsemblGenomes-Tr:CAB13462" /db_xref="GOA:P71018" /db_xref="InterPro:IPR003664" /db_xref="InterPro:IPR012281" /db_xref="PDB:1VI1" /db_xref="SubtiList:BG11843" /db_xref="UniProtKB/Swiss-Prot:P71018" /translation="MRIAVDAMGGDHAPKAVIDGVIKGIEAFDDLHITLVGDKTTIES HLTTTSDRITVLHADEVIEPTDEPVRAVRRKKNSSMVLMAQEVAENRADACISAGNTG ALMTAGLFIVGRIKGIDRPALAPTLPTVSGDGFLLLDVGANVDAKPEHLVQYAIMGSV YSQQVRGVTSPRVGLLNVGTEDKKGNELTKQTFQILKETANINFIGNVEARDLLDDVA DVVVTDGFTGNVTLKTLEGSALSIFKMMRDVMTSTLTSKLAAAVLKPKLKEMKMKMEY SNYGGASLFGLKAPVIKAHGSSDSNAVFHAIRQAREMVSQNVAALIQEEVKEEKTDE* " /label="plsX CDS" gene 1542149..1543150 /gene="plsX" /locus_tag="BSU_15890" /old_locus_tag="BSU15890" /label="plsX gene" CDS 1543169..1544122 /gene="fabD" /locus_tag="BSU_15900" /old_locus_tag="BSU15900" /EC_number="2.3.1.39" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14586097, 19850612" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14586097, 19850612; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malonyl CoA:acyl carrier protein transacylase" /protein_id="NP_389472.1" /db_xref="EnsemblGenomes-Gn:BSU15900" /db_xref="EnsemblGenomes-Tr:CAB13463" /db_xref="GOA:P71019" /db_xref="InterPro:IPR004410" /db_xref="InterPro:IPR014043" /db_xref="InterPro:IPR016035" /db_xref="InterPro:IPR016036" /db_xref="InterPro:IPR020801" /db_xref="InterPro:IPR024925" /db_xref="SubtiList:BG11836" /db_xref="UniProtKB/Swiss-Prot:P71019" /translation="MSKIAFLFPGQGSQFIGMGKELYEQVPAAKRLFDEADETLETKL SSLIFEGDAEELTLTYNAQPALLTTSIAVLEKFKESGITPDFTAGHSLGEYSALVAAG ALSFKDAVYTVRKRGEFMNEAVPAGEGAMAAILGMDAEALKQVTDKVTEEGNLVQLAN LNCPGQIVISGTAKGVELASELAKENGAKRAIPLEVSGPFHSELMKPAAEKLKEVLDA CDIKDADVPVISNVSADVMTEKADIKEKLIEQLYSPVRFEESINKLIAEGVTTFIEIG PGKVLSGLVKKVNRRLKTIAVSDPETIELAIQTLKEENDNA*" /label="fabD CDS" gene 1543169..1544122 /gene="fabD" /locus_tag="BSU_15900" /old_locus_tag="BSU15900" /label="fabD gene" CDS 1544115..1544855 /gene="fabG" /locus_tag="BSU_15910" /old_locus_tag="BSU15910" /EC_number="1.1.1.100" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12655455, 12682299, 19850612, 28126742" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12655455, 12682299, 19850612, 28126742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein reductase" /protein_id="NP_389473.1" /db_xref="EnsemblGenomes-Gn:BSU15910" /db_xref="EnsemblGenomes-Tr:CAB13464" /db_xref="GOA:P51831" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011284" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11535" /db_xref="UniProtKB/Swiss-Prot:P51831" /translation="MLNDKTAIVTGASRGIGRSIALDLAKSGANVVVNYSGNEAKANE VVDEIKSMGRKAIAVKADVSNPEDVQNMIKETLSVFSTIDILVNNAGITRDNLIMRMK EDEWDDVININLKGVFNCTKAVTRQMMKQRSGRIINVSSIVGVSGNPGQANYVAAKAG VIGLTKSSAKELASRNITVNAIAPGFISTDMTDKLAKDVQDEMLKQIPLARFGEPSDV SSVVTFLASEGARYMTGQTLHIDGGMVM*" /label="fabG CDS" gene 1544115..1544855 /gene="fabG" /locus_tag="BSU_15910" /old_locus_tag="BSU15910" /label="fabG gene" promotor_-35 1544886..1544890 /Source="Nicolas_upshift_promotors" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1544906..1544925 /Source="Nicolas_upshift_promotors" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1544911 /Source="Nicolas_upshifts" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1544939..1545172 /gene="acpA" /locus_tag="BSU_15920" /old_locus_tag="BSU15920" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12682299, 19850612, 27467752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12682299, 19850612, 27467752; Product type c: carrier" /codon_start=1 /transl_table=11 /product="acyl carrier protein" /protein_id="NP_389474.1" /db_xref="EnsemblGenomes-Gn:BSU15920" /db_xref="EnsemblGenomes-Tr:CAB13465" /db_xref="GOA:P80643" /db_xref="InterPro:IPR003231" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR036736" /db_xref="PDB:1F80" /db_xref="PDB:1HY8" /db_xref="PDB:2X2B" /db_xref="SubtiList:BG11536" /db_xref="UniProtKB/Swiss-Prot:P80643" /translation="MADTLERVTKIIVDRLGVDEADVKLEASFKEDLGADSLDVVELV MELEDEFDMEISDEDAEKIATVGDAVNYIQNQQ*" /label="acpA CDS" gene 1544939..1545172 /gene="acpA" /locus_tag="BSU_15920" /old_locus_tag="BSU15920" /label="acpA gene" downshifts 1545153 /Source="Nicolas_upshifts" /id="D883" /incds=0 /nref=22 /ntot=197 /MaxReadThrough="8.12206" /MaxDrop="4.1545" /score="-8.42930766" /energy="-17.4" /TU="U1306,U1307,U1308" /idTUdmin="U1306" /TUdmin="-880" /isTUend="FALSE" /label="downshifts" promotor_no_box 1545181..1545281 /Source="Nicolas_upshift_promotors" /id="U1309" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.502497502497502" /psig="0.030969030969031" /xcortree=1637 /SigmaFactorBS="taaaagtcccgccgaaacgcggggctttagccctttattcgt gcagttattacagcatgccgcttttacgcgcgctgtatccggtttagtcagagaagcg c" /listShort="S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 1545241..1545311 /Source="Nicolas_S_feature" /locus_tag="new_1665639_1665709" /HighExp="LBGstat, dia5, Cold, LBGtran, C30, Diami, G135, LBGexp, G/S, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA, SigA" /TUshortPSig="0.031, 1, 1, 0.999" /TUlongSig="SigA, SigA" /TUlongPSig="0.991, 0.991" /label="S577" upshifts 1545241 /Source="Nicolas_upshifts" /id="U1309" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.502497502497502" /psig="0.030969030969031" /xcortree=1637 /SigmaFactorBS="taaaagtcccgccgaaacgcggggctttagccctttattcgt gcagttattacagcatgccgcttttacgcgcgctgtatccggtttagtcagagaagcg c" /listShort="S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1545312..1546061 /gene="rnc" /locus_tag="BSU_15930" /old_locus_tag="BSU15930" /EC_number="3.1.26.3" /experiment="publication(s) with functional evidences, PMID:11123676, 12682299, 16179796, 22412379, 23300471, 26883633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11123676, 12682299, 16179796, 22412379, 23300471, 26883633; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease III" /protein_id="NP_389475.1" /db_xref="EnsemblGenomes-Gn:BSU15930" /db_xref="EnsemblGenomes-Tr:CAB13466" /db_xref="GOA:P51833" /db_xref="InterPro:IPR000999" /db_xref="InterPro:IPR011907" /db_xref="InterPro:IPR014720" /db_xref="InterPro:IPR036389" /db_xref="SubtiList:BG11537" /db_xref="UniProtKB/Swiss-Prot:P51833" /translation="MSKHSHYKDKKKFYKKVEQFKEFQERISVHFQNEKLLYQAFTHS SYVNEHRKKPYEDNERLEFLGDAVLELTISRFLFAKYPAMSEGDLTKLRAAIVCEPSL VSLAHELSFGDLVLLGKGEEMTGGRKRPALLADVFEAFIGALYLDQGLEPVESFLKVY VFPKINDGAFSHVMDFKSQLQEYVQRDGKGSLEYKISNEKGPAHNREFEAIVSLKGEP LGVGNGRSKKEAEQHAAQEALAKLQKHHTKQ*" /label="rnc CDS" gene 1545312..1546061 /gene="rnc" /locus_tag="BSU_15930" /old_locus_tag="BSU15930" /label="rnc gene" downshifts 1546033 /Source="Nicolas_upshifts" /id="D884" /incds=0 /nref=78 /ntot=211 /MaxReadThrough="6.42554" /MaxDrop="5.70849" /score="-8.42930766" /energy="-17.4" /TU="U1307,U1308,U1309" /idTUdmin="U1306" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1546103..1546109 /Source="Nicolas_upshift_promotors" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1546121..1546140 /Source="Nicolas_upshift_promotors" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1546143 /Source="Nicolas_upshifts" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1546162..1549722 /gene="smc" /locus_tag="BSU_15940" /old_locus_tag="BSU15940" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9701812, 12100548, 12682299, 12897137, 15987505, 16272394, 26904953, 28154080" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9701812, 12100548, 12682299, 12897137, 15987505, 16272394, 26904953, 28154080; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chromosome condensation and segregation SMC ATPase" /protein_id="NP_389476.2" /db_xref="EnsemblGenomes-Gn:BSU15940" /db_xref="EnsemblGenomes-Tr:CAB13467" /db_xref="GOA:P51834" /db_xref="InterPro:IPR003395" /db_xref="InterPro:IPR010935" /db_xref="InterPro:IPR011890" /db_xref="InterPro:IPR024704" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036277" /db_xref="PDB:3ZGX" /db_xref="PDB:5H66" /db_xref="PDB:5H67" /db_xref="PDB:5NMO" /db_xref="PDB:5NNV" /db_xref="PDB:5XG3" /db_xref="SubtiList:BG11538" /db_xref="UniProtKB/Swiss-Prot:P51834" /translation="MFLKRLDVIGFKSFAERISVDFVKGVTAVVGPNGSGKSNITDAI RWVLGEQSARSLRGGKMEDIIFAGSDSRKRLNLAEVTLTLDNDDHFLPIDFHEVSVTR RVYRSGESEFLINNQPCRLKDIIDLFMDSGLGKEAFSIISQGKVEEILSSKAEDRRSI FEEAAGVLKYKTRKKKAENKLFETQDNLNRVEDILHELEGQVEPLKIQASIAKDYLEK KKELEHVEIALTAYDIEELHGKWSTLKEKVQMAKEEELAESSAISAKEAKIEDTRDKI QALDESVDELQQVLLVTSEELEKLEGRKEVLKERKKNAVQNQEQLEEAIVQFQQKETV LKEELSKQEAVFETLQAEVKQLRAQVKEKQQALSLHNENVEEKIEQLKSDYFELLNSQ ASIRNELQLLDDQMSQSAVTLQRLADNNEKHLQERHDISARKAACETEFARIEQEIHS QVGAYRDMQTKYEQKKRQYEKNESALYQAYQYVQQARSKKDMLETMQGDFSGFYQGVK EVLKAKERLGGIRGAVLELISTEQKYETAIEIALGASAQHVVTDDEQSARKAIQYLKQ NSFGRATFLPLSVIRDRQLQSRDAETAARHSSFLGVASELVTFDPAYRSVIQNLLGTV LITEDLKGANELAKLLGHRYRIVTLEGDVVNPGGSMTGGAVKKKNNSLLGRSRELEDV TKRLAEMEEKTALLEQEVKTLKHSIQDMEKKLADLRETGEGLRLKQQDVKGQLYELQV AEKNINTHLELYDQEKSALSESDEERKVRKRKLEEELSAVSEKMKQLEEDIDRLTKQK QTQSSTKESLSNELTELKIAAAKKEQACKGEEDNLARLKKELTETELALKEAKEDLSF LTSEMSSSTSGEEKLEEAAKHKLNDKTKTIELIALRRDQRIKLQHGLDTYERELKEMK RLYKQKTTLLKDEEVKLGRMEVELDNLLQYLREEYSLSFEGAKEKYQLETDPEEARKR VKLIKLAIEELGTVNLGSIDEFERVNERYKFLSEQKEDLTEAKNTLFQVIEEMDEEMT KRFNDTFVQIRSHFDQVFRSLFGGGRAELRLTDPNDLLHSGVEIIAQPPGKKLQNLNL LSGGERALTAIALLFSILKVRPVPFCVLDEVEAALDEANVFRFAQYLKKYSSDTQFIV ITHRKGTMEEADVLYGVTMQESGVSKVISVKLEETKEFVQ*" /label="smc CDS" gene 1546162..1549722 /gene="smc" /locus_tag="BSU_15940" /old_locus_tag="BSU15940" /label="smc gene" S_feature complement(1549656..1550726) /Source="Nicolas_S_feature" /locus_tag="new_1670054_1671124_c" /HighExp="Cold, C30, Gly, T0.30H, Pyr, T-4.40H, G135, Lbstat, Fru, T-5.40H" /AntisenseName="ftsY" /AntisenseCor="-3.7172405649441298E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S578" CDS 1549742..1550731 /gene="ftsY" /locus_tag="BSU_15950" /old_locus_tag="BSU15950" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11021934, 11123669, 11166993, 12682299, 15995216, 16705751, 22056770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11021934, 11123669, 11166993, 12682299, 15995216, 16705751, 22056770; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="signal recognition particle (docking protein)" /protein_id="NP_389477.1" /db_xref="EnsemblGenomes-Gn:BSU15950" /db_xref="EnsemblGenomes-Tr:CAB13468" /db_xref="GOA:P51835" /db_xref="InterPro:IPR000897" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004390" /db_xref="InterPro:IPR013822" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036225" /db_xref="SubtiList:BG11539" /db_xref="UniProtKB/Swiss-Prot:P51835" /translation="MSFFKKLKEKITKQTDSVSEKFKDGLEKTRNSFQNKVNDLVSRY RKVDEDFFEELEEVLISADVGFTTVMELIDELKKEVKRRNIQDPKEVQSVISEKLVEI YNSGDEQISELNIQDGRLNVILLVGVNGVGKTTTIGKLAHKMKQEGKSVVLAAGDTFR AGAIEQLEVWGERTGVPVIKQTAGSDPAAVIYDAVHAAKARNADVLICDTAGRLQNKV NLMKELEKVKRVIEREVPEAPHEVLLALDATTGQNAMAQAKEFSKATNVTGIALTKLD GTAKGGIVLAIRNELHIPVKLVGLGEKVDDLQEFDPESYVYGLFSDLVEKADD*" /label="ftsY CDS" gene 1549742..1550731 /gene="ftsY" /locus_tag="BSU_15950" /old_locus_tag="BSU15950" /label="ftsY gene" downshifts 1550718 /Source="Nicolas_upshifts" /id="D885" /incds=0 /nref=220 /ntot=261 /MaxReadThrough="2.98458" /MaxDrop="6.84303" /score="49.5808683" /energy="-14.4" /TU="NA" /idTUdmin="U1307" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1550768..1551253) /gene="ylqB" /locus_tag="BSU_15960" /old_locus_tag="BSU15960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535, 22287527" /codon_start=1 /transl_table=11 /product="conserved exported protein of unknown function" /protein_id="NP_389478.1" /db_xref="EnsemblGenomes-Gn:BSU15960" /db_xref="EnsemblGenomes-Tr:CAB13469" /db_xref="GOA:O31737" /db_xref="InterPro:IPR008969" /db_xref="InterPro:IPR008979" /db_xref="SubtiList:BG13401" /db_xref="UniProtKB/Swiss-Prot:O31737" /translation="MKKIGLLFMLCLAALFTIGFPAQQADAAEAPYKASITNISTDGG VYGKINYGQGQYWRVKYNITVSGKLLDQNGQPVPNAPVRFEADTKVGNTTQTASGTTD ANGTFEVPMYLGPAAGYYTYYTSVSVHYYDIIPFRVFSGESRLVSTDNSLYHFAYQVR R*" /label="ylqB CDS" gene complement(1550768..1551253) /gene="ylqB" /locus_tag="BSU_15960" /old_locus_tag="BSU15960" /label="ylqB gene" downshifts complement(1550771) /Source="Nicolas_upshifts" /id="D886" /incds=0 /nref=139 /ntot=244 /MaxReadThrough="6.77251" /MaxDrop="6.10895" /score="32.8428224" /energy="-14.4" /TU="U1311" /idTUdmin="U1311" /TUdmin="-1076" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1551275..1551293) /Source="Nicolas_upshift_promotors" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1551291) /Source="Nicolas_upshifts" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1551307..1551314) /Source="Nicolas_upshift_promotors" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1551356..1551362 /Source="Nicolas_upshift_promotors" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1551377..1551396 /Source="Nicolas_upshift_promotors" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1551379 /Source="Nicolas_upshifts" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1551430..1551762 /gene="ylxM" /locus_tag="BSU_15970" /old_locus_tag="BSU15970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11274114, 24659773; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the signal recognition particle (SRP) protein-targeting pathway" /protein_id="NP_389479.1" /db_xref="EnsemblGenomes-Gn:BSU15970" /db_xref="EnsemblGenomes-Tr:CAB13470" /db_xref="GOA:P37104" /db_xref="InterPro:IPR007394" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10829" /db_xref="UniProtKB/Swiss-Prot:P37104" /translation="MSLEKTTRMNYLFDFYQSLLTSKQKSYMSLYYLDDFSLGEIAEE YEVSRQAVYDNIKRTEAMLEQYEEKLLLLKKFQERKEMFNKLKELASGSKEEEEITAL IEALEKLD*" /label="ylxM CDS" gene 1551430..1551762 /gene="ylxM" /locus_tag="BSU_15970" /old_locus_tag="BSU15970" /label="ylxM gene" downshifts complement(1551433) /Source="Nicolas_upshifts" /id="D887" /incds=0 /nref=3 /ntot=52 /MaxReadThrough="1.40385" /MaxDrop="4.6092" /score="32.8428224" /energy="-14.4" /TU="NA" /idTUdmin="U1311" /TUdmin="-1738" /isTUend="FALSE" /label="downshifts" CDS 1551776..1553116 /gene="ffh" /locus_tag="BSU_15980" /old_locus_tag="BSU15980" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7511896, 8662730, 10222262, 10224127, 10658653, 12682299, 11123669, 22056770, 26344568" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7511896, 8662730, 10222262, 10224127, 10658653, 12682299, 11123669, 22056770, 26344568; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="signal recognition particle-like (SRP) GTPase" /protein_id="NP_389480.1" /db_xref="EnsemblGenomes-Gn:BSU15980" /db_xref="EnsemblGenomes-Tr:CAB13471" /db_xref="GOA:P37105" /db_xref="InterPro:IPR000897" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004125" /db_xref="InterPro:IPR004780" /db_xref="InterPro:IPR013822" /db_xref="InterPro:IPR022941" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036891" /db_xref="PDB:4UE4" /db_xref="SubtiList:BG10830" /db_xref="UniProtKB/Swiss-Prot:P37105" /translation="MAFEGLADRLQQTISKIRGKGKVSEQDVKEMMREVRLALLEADV NFKVVKDFVKKVSERAVGQDVMKSLTPGQQVIKVVQEELTELMGGEESKIAVAKRPPT VIMMVGLQGAGKTTTSGKLANLLRKKHNRKPMLVAADIYRPAAIKQLETLGKQLDMPV FSLGDQVSPVEIAKQAIEKAKEEHYDYVILDTAGRLHIDHELMDELTNVKEIANPEEI FLVVDSMTGQDAVNVAKSFNEQLGLTGVVLTKLDGDTRGGAALSIRAVTNTPIKFAGL GEKLDALEPFHPERMASRILGMGDVLTLIEKAQASVDEDKAKELEQKMRTMSFTLDDF LEQLGQVRNMGPLDELLQMMPGAGKMKGLKNIQVDEKQLNHVEAIIKSMTVLEKEQPD IINASRRKRIAKGSGTSVQEVNRLLKQFDEMKKMMKQMTNMSKGKKKGFKLPFM*" /label="ffh CDS" gene 1551776..1553116 /gene="ffh" /locus_tag="BSU_15980" /old_locus_tag="BSU15980" /label="ffh gene" S_feature 1553117..1553221 /Source="Nicolas_S_feature" /locus_tag="new_1673515_1673619" /HighExp="Cold, G135, C30, G180, LPhT, HPh, Paraq, LPh, Oxctl, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S579" CDS 1553222..1553494 /gene="rpsP" /locus_tag="BSU_15990" /old_locus_tag="BSU15990" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6419023, 12682299, 20034956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6419023, 12682299, 20034956; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S16 (BS17)" /protein_id="NP_389481.1" /db_xref="EnsemblGenomes-Gn:BSU15990" /db_xref="EnsemblGenomes-Tr:CAB13472" /db_xref="GOA:P21474" /db_xref="InterPro:IPR000307" /db_xref="InterPro:IPR020592" /db_xref="InterPro:IPR023803" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10831" /db_xref="UniProtKB/Swiss-Prot:P21474" /translation="MAVKIRLKRMGAKKSPFYRIVVADSRSPRDGRFIETVGTYNPVA KPAEVKIDEELALKWLQTGAKPSDTVRNLFSSQGIMEKFHNAKQGK*" /label="rpsP CDS" gene 1553222..1553494 /gene="rpsP" /locus_tag="BSU_15990" /old_locus_tag="BSU15990" /label="rpsP gene" CDS 1553494..1553739 /gene="ylqC" /locus_tag="BSU_16000" /old_locus_tag="BSU16000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 22720735, 26483775; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding protein" /protein_id="NP_389482.1" /db_xref="EnsemblGenomes-Gn:BSU16000" /db_xref="EnsemblGenomes-Tr:CAB13473" /db_xref="GOA:O31738" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR020627" /db_xref="SubtiList:BG13402" /db_xref="UniProtKB/Swiss-Prot:O31738" /translation="MTDQHLEDLIVHIVTPLVDHPDDIRVIREETDQKIALRLSVHKS DTGKVIGKQGRTAKAIRTAVFAAGVQSSKKVQFEIFD*" /label="ylqC CDS" gene 1553494..1553739 /gene="ylqC" /locus_tag="BSU_16000" /old_locus_tag="BSU16000" /label="ylqC gene" downshifts 1553711 /Source="Nicolas_upshifts" /id="D888" /incds=0 /nref=41 /ntot=178 /MaxReadThrough="6.57974" /MaxDrop="4.803" /score="-7.01631592" /energy="-5.6" /TU="U1312" /idTUdmin="U1312" /TUdmin="-1804" /isTUend="FALSE" /label="downshifts" S_feature 1553756..1553860 /Source="Nicolas_S_feature" /locus_tag="new_1674154_1674258" /HighExp="G180, Oxctl, G150, G135, Paraq, LBGexp, H2O2, HPh, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S580" CDS 1553861..1554247 /gene="ylqD" /locus_tag="BSU_16010" /old_locus_tag="BSU16010" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389483.1" /db_xref="EnsemblGenomes-Gn:BSU16010" /db_xref="EnsemblGenomes-Tr:CAB13474" /db_xref="InterPro:IPR021297" /db_xref="SubtiList:BG13403" /db_xref="UniProtKB/Swiss-Prot:O31739" /translation="MQIIHRVAVMQVLTERSKEKLLASFAEKKQMLERECSQLYFQLR KHEKEQQNPNMIEQFKKAIEKRKDDIKIIDFQIAQVHTLPLGSELKEKEVDALLTIEA GDDWHEKTAANTIVIKDGKVIEIRQR*" /label="ylqD CDS" gene 1553861..1554247 /gene="ylqD" /locus_tag="BSU_16010" /old_locus_tag="BSU16010" /label="ylqD gene" CDS 1554252..1554776 /gene="rimM" /locus_tag="BSU_16020" /old_locus_tag="BSU16020" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15496525, 16014871, 27382067; Product type f: factor" /codon_start=1 /transl_table=11 /product="16S rRNA processing protein" /protein_id="NP_389484.1" /db_xref="EnsemblGenomes-Gn:BSU16020" /db_xref="EnsemblGenomes-Tr:CAB13475" /db_xref="GOA:O31740" /db_xref="InterPro:IPR002676" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR011961" /db_xref="InterPro:IPR027275" /db_xref="InterPro:IPR036976" /db_xref="SubtiList:BG13404" /db_xref="UniProtKB/Swiss-Prot:O31740" /translation="MTKRWFNVGKIVNTHGIKGEVRVISKTDFAEERYKPGNTLYLFM DGRNEPVEVTVNTHRLHKQFHLLQFKERQNLNEVEELKNAIIKVPEEELGELNEGEFY FHEIIGCEVFTEEGELIGKVKEILTPGANDVWVIGRKGKKDALIPYIESVVKHIDVRE KKIEIELMEGLIDE*" /label="rimM CDS" gene 1554252..1554776 /gene="rimM" /locus_tag="BSU_16020" /old_locus_tag="BSU16020" /label="rimM gene" CDS 1554773..1555504 /gene="trmD" /locus_tag="BSU_16030" /old_locus_tag="BSU16030" /EC_number="2.1.1.228" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094308, 11532950, 12682299, 12773376, 15060037, 27881678, 28601227; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA(m1G37)methyltransferase" /protein_id="NP_389485.1" /db_xref="EnsemblGenomes-Gn:BSU16030" /db_xref="EnsemblGenomes-Tr:CAB13476" /db_xref="GOA:O31741" /db_xref="InterPro:IPR002649" /db_xref="InterPro:IPR016009" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="SubtiList:BG12687" /db_xref="UniProtKB/Swiss-Prot:O31741" /translation="MKIDFLTLFPEMFEGVLGSSILQKAQEKDAVQFQVVNFREYSDN KHNTVDDYPYGGGAGMVLKPQPVFDAVEDLTSKAAAAPRIILVCPQGERFTQKKAEQL AKEEHLLFICGHYEGYDERIREHLVTDEISIGDFVLTGGELPAMMIADSVVRLLPGVL GKEASHIEDSFSTGLLEHPHYTRPADYKGLKVPETLLSGNHAKIEEWRNKESIRRTYL RRPDLLKDHPLTEQQRKWISEWEKE*" /label="trmD CDS" gene 1554773..1555504 /gene="trmD" /locus_tag="BSU_16030" /old_locus_tag="BSU16030" /label="trmD gene" promotor_-35 1555510..1555517 /Source="Nicolas_upshift_promotors" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1555531..1555550 /Source="Nicolas_upshift_promotors" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1555535 /Source="Nicolas_upshifts" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" misc_RNA 1555583..1555624 /locus_tag="BSU_misc_RNA_30" /product="L19_leader" /label="L19 leader RNA" gene 1555583..1555624 /locus_tag="BSU_misc_RNA_30" /label="gene" CDS 1555644..1555991 /gene="rplS" /locus_tag="BSU_16040" /old_locus_tag="BSU16040" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16272117, 27477481; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L19" /protein_id="NP_389486.2" /db_xref="EnsemblGenomes-Gn:BSU16040" /db_xref="EnsemblGenomes-Tr:CAB13477" /db_xref="GOA:O31742" /db_xref="InterPro:IPR001857" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR018257" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG12667" /db_xref="UniProtKB/Swiss-Prot:O31742" /translation="MQKLIEDITKEQLRTDLPAFRPGDTLRVHVKVVEGNRERIQIFE GVVIKRRGGGISETFTVRKISYGVGVERTFPVHTPKIAKIEVVRYGKVRRAKLYYLRE LRGKAARIKEIRR*" /label="rplS CDS" gene 1555644..1555991 /gene="rplS" /locus_tag="BSU_16040" /old_locus_tag="BSU16040" /label="rplS gene" downshifts 1555993 /Source="Nicolas_upshifts" /id="D889" /incds=0 /nref=212 /ntot=274 /MaxReadThrough="6.00308" /MaxDrop="9.06015" /score="23.9942041" /energy="-12.6" /TU="U1313" /idTUdmin="U1312" /TUdmin=478 /isTUend="FALSE" /label="downshifts" promotor_-35 1556046..1556052 /Source="Nicolas_upshift_promotors" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1556065..1556133 /Source="Nicolas_S_feature" /locus_tag="new_1676463_1676531" /HighExp="Oxctl, G180, Paraq, G135, H2O2, LBGstat, dia15, G150, HPh, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.149563" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S581" upshifts 1556065 /Source="Nicolas_upshifts" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1556066..1556085 /Source="Nicolas_upshift_promotors" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1556134..1556982 /gene="rbgA" /locus_tag="BSU_16050" /old_locus_tag="BSU16050" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16390447, 16431913, 16997968, 17613524, 22267738, 25330043, 26951678" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16390447, 16431913, 16997968, 17613524, 22267738, 25330043, 26951678; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome biogenesis GTPase A" /protein_id="NP_389487.1" /db_xref="EnsemblGenomes-Gn:BSU16050" /db_xref="EnsemblGenomes-Tr:CAB13478" /db_xref="GOA:O31743" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR016478" /db_xref="InterPro:IPR019991" /db_xref="InterPro:IPR023179" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="PDB:1PUJ" /db_xref="SubtiList:BG13405" /db_xref="UniProtKB/Swiss-Prot:O31743" /translation="MTIQWFPGHMAKARREVTEKLKLIDIVYELVDARIPMSSRNPMI EDILKNKPRIMLLNKADKADAAVTQQWKEHFENQGIRSLSINSVNGQGLNQIVPASKE ILQEKFDRMRAKGVKPRAIRALIIGIPNVGKSTLINRLAKKNIAKTGDRPGITTSQQW VKVGKELELLDTPGILWPKFEDELVGLRLAVTGAIKDSIINLQDVAVFGLRFLEEHYP ERLKERYGLDEIPEDIAELFDAIGEKRGCLMSGGLINYDKTTEVIIRDIRTEKFGRLS FEQPTM*" /label="rbgA CDS" gene 1556134..1556982 /gene="rbgA" /locus_tag="BSU_16050" /old_locus_tag="BSU16050" /label="rbgA gene" promotor_-35 1557003..1557010 /Source="Nicolas_upshift_promotors" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1557023..1557041 /Source="Nicolas_upshift_promotors" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1557033 /Source="Nicolas_upshifts" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1557053..1557820 /gene="rnhB" /locus_tag="BSU_16060" /old_locus_tag="BSU16060" /EC_number="3.1.26.4" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10094689, 12475934, 23882084, 23937561, 29078353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094689, 12475934, 23882084, 23937561, 29078353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease HII" /protein_id="NP_389488.1" /db_xref="EnsemblGenomes-Gn:BSU16060" /db_xref="EnsemblGenomes-Tr:CAB13479" /db_xref="GOA:O31744" /db_xref="InterPro:IPR001352" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR022898" /db_xref="InterPro:IPR024567" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12666" /db_xref="UniProtKB/Swiss-Prot:O31744" /translation="MNTLTVKDIKDRLQEVKDAQDPFIAQCENDPRKSVQTLVEQWLK KQAKEKALKEQWVNMTSYERLARNKGFRLIAGVDEVGRGPLAGPVVASAVILPEECEI LGLTDSKKLSEKKREEYYELIMKEALAVGIGIVEATVIDEINIYEASKMAMVKAIQDL SDTPDYLLVDAMTLPLDTAQASIIKGDAKSVSIAAGACIAKVTRDRMMSAYAETYPMY GFEKNKGYGTKEHLEALAAYGPTELHRKTFAPVQSFR*" /label="rnhB CDS" gene 1557053..1557820 /gene="rnhB" /locus_tag="BSU_16060" /old_locus_tag="BSU16060" /label="rnhB gene" CDS 1557852..1559582 /gene="ylqG" /locus_tag="BSU_16070" /old_locus_tag="BSU16070" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389489.1" /db_xref="EnsemblGenomes-Gn:BSU16070" /db_xref="EnsemblGenomes-Tr:CAB13480" /db_xref="SubtiList:BG13406" /db_xref="UniProtKB/Swiss-Prot:O31745" /translation="MNIRNDVQKALQHLFGRTAVPQETSKVNEALNGEKRLLLGKVLR LLGDQHALIQVGNQTVQGKLETQLRPQAYYWFSYEKKTAEQTGRLQVVQSFDQNPKTI QDAAGKLLNAISVKTSNAALMMTGAMLKSKTPVTENDIKTAVRWMDTLPSQDTKKAVE TVLFALKRDLPIHSEILNGVHAVKSPVPLHQHVSQLLQAIDQNPQQSQMMSKLKEAVT VLLNSEIDVHAERLIDKLISLTDNTKAPSPTNTAGSRELSTPAGSPGKASLPIANHTA EQGSIQEEPVKTAADIPIKEARQLLVKLTESAEKNSLQIVKEAANWIKAAASSGDSKS LAASAVLQAAQVTDQEAEVFLKAVQQTAPHLADKADVLSFLSKVKTAIGARDEVAFIK AFEQGSAVTSGEMQSIKLALSALRASHEVAEPVKQEADQLFHKLNGQLFMQQDHPSYS QIVMSFPMFSKSGVQDMTVLFKGKKEADGKLDPSHCRLLFLLQLDTLKETVVDCLVQQ KVMTITIETDFELQAAIDPMVPALKQGLKEMGYSLSGVNAKKRVHTEEKASIDQYITS ISDQEVDVKI*" /label="ylqG CDS" gene 1557852..1559582 /gene="ylqG" /locus_tag="BSU_16070" /old_locus_tag="BSU16070" /label="ylqG gene" upshifts complement(1559089) /Source="Nicolas_upshifts" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1559090..1559109) /Source="Nicolas_upshift_promotors" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1559124..1559131) /Source="Nicolas_upshift_promotors" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1559579..1559860 /gene="ylqH" /locus_tag="BSU_16080" /old_locus_tag="BSU16080" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative flagellar biosynthesis protein" /protein_id="NP_389490.1" /db_xref="EnsemblGenomes-Gn:BSU16080" /db_xref="EnsemblGenomes-Tr:CAB13481" /db_xref="GOA:O34867" /db_xref="InterPro:IPR004683" /db_xref="InterPro:IPR006135" /db_xref="InterPro:IPR029025" /db_xref="SubtiList:BG13407" /db_xref="UniProtKB/Swiss-Prot:O34867" /translation="MKEQTPIRKAVALHYDEQKDKAPRVIATGKGHVADNIIKEAKKA GVPIQEDRTLVELMRHLTVDDQIPEALYETVAEIFSFIYKLDESVKNKK*" /label="ylqH CDS" gene 1559579..1559860 /gene="ylqH" /locus_tag="BSU_16080" /old_locus_tag="BSU16080" /label="ylqH gene" downshifts 1559692 /Source="Nicolas_upshifts" /id="D890" /incds=1 /nref=7 /ntot=136 /MaxReadThrough="4.03339" /MaxDrop="4.52065" /score="-6.81136789" /energy="-9.2" /TU="U1313,U1315" /idTUdmin="U1313" /TUdmin="-267" /isTUend="FALSE" /label="downshifts" S_feature 1559861..1559980 /Source="Nicolas_S_feature" /locus_tag="new_1680259_1680378" /HighExp="Cold, Lbstat, H2O2, Glu, Paraq, Mal, G135, GM 90, Oxctl, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S582" promotor_-35 1559952..1559959 /Source="Nicolas_upshift_promotors" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1559973..1559992 /Source="Nicolas_upshift_promotors" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1559982 /Source="Nicolas_upshifts" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1560033..1561190 /gene="sucC" /locus_tag="BSU_16090" /old_locus_tag="BSU16090" /EC_number="6.2.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2548486, 22720735, 22751660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinyl-CoA synthetase (beta subunit)" /protein_id="NP_389491.1" /db_xref="EnsemblGenomes-Gn:BSU16090" /db_xref="EnsemblGenomes-Tr:CAB13482" /db_xref="GOA:P80886" /db_xref="InterPro:IPR005809" /db_xref="InterPro:IPR005811" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013650" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016102" /db_xref="InterPro:IPR017866" /db_xref="SubtiList:BG12680" /db_xref="UniProtKB/Swiss-Prot:P80886" /translation="MNIHEYQGKEVLRKYGVSVPEGKVAFTAEEAVESAKSLSSSVYV VKAQIHAGGRGKAGGVKIAKSLDEVKAYAEELLGKTLVTHQTGPDGQVIKRLLIEEGC DIKKEYYIGLVLDRATSRIVLMASEEGGTEIEEVAEKTPEKIKKAVIDPAVGLQGYQA REIAFAINIPKELVGKAAKFMLGLYKAFVEKDCSIAEINPLVVTGDGNVMALDAKLNF DSNALYRQKDIMEYRDLDEEDPKEIEASKYDLSYISLDGNIGCMVNGAGLAMSTMDII KHYGGEPANFLDVGGGATAEKVTEAFKIILSDQNVKGIFVNIFGGIMKCDVIAEGVVE ATRQVGLTLPLVVRLEGTNVDLGKKILSESGLNITSAESMADGAQKIVSLV*" /label="sucC CDS" gene 1560033..1561190 /gene="sucC" /locus_tag="BSU_16090" /old_locus_tag="BSU16090" /label="sucC gene" promotor_no_box complement(1560105..1560205) /Source="Nicolas_upshift_promotors" /id="U1318" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.864135864135864" /psig="0.0929070929070929" /xcortree=73 /SigmaFactorBS="ccagctttgcctcgaccgccagcatgaatttgagcctttacg acataaaccgagctggataagctctttgcactctcaactgcttcttctgctgtaaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1560145) /Source="Nicolas_upshifts" /id="U1318" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.864135864135864" /psig="0.0929070929070929" /xcortree=73 /SigmaFactorBS="ccagctttgcctcgaccgccagcatgaatttgagcctttacg acataaaccgagctggataagctctttgcactctcaactgcttcttctgctgtaaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1561219..1562121 /gene="sucD" /locus_tag="BSU_16100" /old_locus_tag="BSU16100" /EC_number="6.2.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9643546, 22720735, 22751660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinyl-CoA synthetase (alpha subunit)" /protein_id="NP_389492.1" /db_xref="EnsemblGenomes-Gn:BSU16100" /db_xref="EnsemblGenomes-Tr:CAB13483" /db_xref="GOA:P80865" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR005810" /db_xref="InterPro:IPR005811" /db_xref="InterPro:IPR016102" /db_xref="InterPro:IPR017440" /db_xref="InterPro:IPR033847" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12681" /db_xref="UniProtKB/Swiss-Prot:P80865" /translation="MSVFINKDTRVIVQGITGSTALFHTKQMLEYGTNIVGGVTPGKG GTEAEGVPVFNTVAEAVQTTGANASVIYVPAPFAADAIMEAVDAELDLVICITEHIPV LDMVKVKRFMEGKKTRLIGPNCPGVITPEECKIGIMPGYIHKKGHVGVVSRSGTLTYE AVHQLSEAGVGQSTAVGIGGDPVNGTNFIDVLKAFNEDPDTHAVIMIGEIGGTAEEEA AEWVKANMTKPVVGFIGGKTAPPGKRMGHAGAIISGGKGTADEKIKTLNACGIEVAET PSVMGETLIKVLKEKNLFETCKTH*" /label="sucD CDS" gene 1561219..1562121 /gene="sucD" /locus_tag="BSU_16100" /old_locus_tag="BSU16100" /label="sucD gene" downshifts 1562111 /Source="Nicolas_upshifts" /id="D891" /incds=0 /nref=94 /ntot=208 /MaxReadThrough="5.40077" /MaxDrop="4.8878" /score="9.51199539" /energy="-15" /TU="U1317" /idTUdmin="U1315" /TUdmin=2130 /isTUend="FALSE" /label="downshifts" CDS 1562182..1563075 /gene="dprA" /locus_tag="BSU_16110" /old_locus_tag="BSU16110" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16014871, 16978360, 17803906, 18045469, 7768823, 23779106, 25138221, 28618091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 16978360, 17803906, 18045469, 7768823, 23779106, 25138221, 28618091; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA processing Smf single strand binding protein" /protein_id="NP_389493.1" /db_xref="EnsemblGenomes-Gn:BSU16110" /db_xref="EnsemblGenomes-Tr:CAB13484" /db_xref="GOA:P39813" /db_xref="InterPro:IPR003488" /db_xref="SubtiList:BG11006" /db_xref="UniProtKB/Swiss-Prot:P39813" /translation="MDQAAVCLTICRINQLLSPSLLLKWWKADPSMSLTSPVLQTVTR DQIKAAALKNEIEQFYPKLPRVLAAYREQGINTIPISSKQYPFWLKSIYDPPAVLFAK GDMTLLSKGRKIGIVGTRNPTAYGKQVVNHLTKEICRKGWVIVSGLASGIDGMSHAAS IKAKGRTIGVIAGGFQHIYPRENLQLADHMAKHHILLSEHPPETKPQKWHFPMRNRII SGLSEGVIVVQGKEKSGSLITAYQALEQGREVFAVPGSLFDPYAGGPIKLIQQGAKAI WSAEDIFEELPERNVQYTEPF*" /label="dprA CDS" gene 1562182..1563075 /gene="dprA" /locus_tag="BSU_16110" /old_locus_tag="BSU16110" /label="dprA gene" promotor_-35 1563081..1563088 /Source="Nicolas_upshift_promotors" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1563103..1563122 /Source="Nicolas_upshift_promotors" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1563110..1563262 /Source="Nicolas_S_feature" /locus_tag="new_1683508_1683660" /HighExp="dia15, H2O2, G/S, Paraq, Diami, S1, Oxctl, LBGexp, C30, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.111279" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigD, SigA, SigA" /TUlongPSig="1, 1, 1" /label="S583" upshifts 1563110 /Source="Nicolas_upshifts" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1563263..1565338 /gene="topA" /locus_tag="BSU_16120" /old_locus_tag="BSU16120" /EC_number="5.99.1.2" /function="16.3: Control" /function="16.6: Maintain" /function="16.9: Replicate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9580687, 12682299, 16585761, 23133654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9580687, 12682299, 16585761, 23133654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA topoisomerase I" /protein_id="NP_389494.1" /db_xref="EnsemblGenomes-Gn:BSU16120" /db_xref="EnsemblGenomes-Tr:CAB13485" /db_xref="GOA:P39814" /db_xref="InterPro:IPR000380" /db_xref="InterPro:IPR003601" /db_xref="InterPro:IPR003602" /db_xref="InterPro:IPR005733" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013497" /db_xref="InterPro:IPR013498" /db_xref="InterPro:IPR013825" /db_xref="InterPro:IPR023405" /db_xref="InterPro:IPR023406" /db_xref="InterPro:IPR028612" /db_xref="InterPro:IPR034149" /db_xref="SubtiList:BG11007" /db_xref="UniProtKB/Swiss-Prot:P39814" /translation="MSDYLVIVESPAKAKTIERYLGKKYKVKASMGHVRDLPKSQMGV DIEQNFEPKYITIRGKGPVLKELKTAAKKAKKVYLAADPDREGEAIAWHLAHSLDLDL NSDCRVVFNEITKDAIKESFKHPRMINMDLVDAQQARRILDRLVGYKISPILWKKVKK GLSAGRVQSVALRLIIDREKEINDFKPEEYWTIDGTFLKGQETFEASFFGKNGKKLPL NSEADVKEILSQLKGNQYTVEKVTKKERKRNPALPFTTSTLQQEAARKLNFRAKKTMM IAQQLYEGIDLGREGTVGLITYMRTDSTRISNTAVDEAAAFIDQTYGKEFLGGKRKPA KKNENAQDAHEAIRPTSVLRKPSELKAVLGRDQMRLYKLIWERFVASQMAPAVLDTMS VDLTNNGLTFRANGSKVKFSGFMKVYVEGKDDQMEEKDRMLPDLQEGDTVLSKDIEPE QHFTQPPPRYTEARLVKTLEERGIGRPSTYAPTLDTIQRRGYVALDNKRFVPTELGQI VLDLIMEFFPEIINVEFTAKMERDLDHVEEGNTEWVKIIDNFYTDFEKRVKKAESEMK EVEIEPEYAGEDCELCSSPMVYKMGRYGKFLACSNFPDCRNTKPIVKQIGVKCPSCGE GNIVERKSKKKRVFYGCDRYPDCEFVSWDKPIERKCPKCGKMLVEKKLKKGIQVQCVE CDYKEEPQK*" /label="topA CDS" gene 1563263..1565338 /gene="topA" /locus_tag="BSU_16120" /old_locus_tag="BSU16120" /label="topA gene" downshifts 1565308 /Source="Nicolas_upshifts" /id="D892" /incds=0 /nref=48 /ntot=173 /MaxReadThrough="5.66787" /MaxDrop="4.5486" /score="0.939045188" /energy="-13.2" /TU="U1319" /idTUdmin="U1317" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-35 1565370..1565375 /Source="Nicolas_upshift_promotors" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1565382 /Source="Nicolas_upshifts" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1565391..1565409 /Source="Nicolas_upshift_promotors" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1565414..1566721 /gene="trmFO" /locus_tag="BSU_16130" /old_locus_tag="BSU16130" /EC_number="2.1.1.74" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16027442, 21561081, 23095745, 23157377, 27825927, 28745052" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16027442, 21561081, 23095745, 23157377, 27825927, 28745052; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA:m(5)U-54 methyltransferase" /protein_id="NP_389495.1" /db_xref="EnsemblGenomes-Gn:BSU16130" /db_xref="EnsemblGenomes-Tr:CAB13486" /db_xref="GOA:P39815" /db_xref="InterPro:IPR002218" /db_xref="InterPro:IPR004417" /db_xref="InterPro:IPR020595" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11008" /db_xref="UniProtKB/Swiss-Prot:P39815" /translation="MNQQTVNVIGAGLAGSEAAWQLAKRGIQVKLYEMRPVKQTPAHH TDKFAELVCSNSLRSNTLANAVGVLKEEMRALDSAIIAAADECSVPAGGALAVDRHEF AASVTNRVKNHPNVTVINEEVTEIPEGPTIIATGPLTSESLSAQLKELTGEDYLYFYD AAAPIVEKDSLDMDKVYLKSRYDKGEAAYLNCPMTEEEFDRFHEALTSAETVPLKEFE KEIFFEGCMPIEVMAKRGKKTMLFGPMKPVGLEHPVTGKRPYAVVQLRQDDAAGTLYN IVGFQTHLKWGDQKEVLKLIPGLENVEIVRYGVMHRNTFINSPSLLKPTYQFKNRSDL FFAGQMTGVEGYVESAASGLVAGINAAKLVLGEELVIFPQETAIGSMAHYITTTNQKN FQPMNANFGLLKELPVKIKNKKERNEQYANRAIETIQTISKTI*" /label="trmFO CDS" gene 1565414..1566721 /gene="trmFO" /locus_tag="BSU_16130" /old_locus_tag="BSU16130" /label="trmFO gene" promotor_-35 1566727..1566731 /Source="Nicolas_upshift_promotors" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1566748..1566767 /Source="Nicolas_upshift_promotors" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1566758 /Source="Nicolas_upshifts" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1566789..1567703 /gene="codV" /locus_tag="BSU_16140" /old_locus_tag="BSU16140" /function="16.9: Replicate" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10498718, 11208805, 16553881, 16597952, 21239579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498718, 11208805, 16553881, 16597952, 21239579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="site-specific tyrosine recombinase for chromosome partitioning" /protein_id="NP_389496.1" /db_xref="EnsemblGenomes-Gn:BSU16140" /db_xref="EnsemblGenomes-Tr:CAB13487" /db_xref="GOA:P39776" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR004107" /db_xref="InterPro:IPR010998" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR011931" /db_xref="InterPro:IPR013762" /db_xref="InterPro:IPR023009" /db_xref="SubtiList:BG10965" /db_xref="UniProtKB/Swiss-Prot:P39776" /translation="MENVKNFVKLFVEYLQIEKNYSQYTIVNYVDSIEEFETFLRVQG INGFEEAAYQDTRIFLTEAYEKGLSRRTISKKISALRSFYKFLMREKLIEENPFQLVH LPKQEKRIPKFLYQKELEELFEVSDISQPAGMRDQALLELLYATGMRVSECCSITIND VDLFMDTVLVHGKGKKQRYIPFGSYAREALKVYMNSGRQCLLMKAKEPHDLLFVNQRG GPLTARGIRHILSGLVQKASSTLHIHPHMLRHTFATHLLNEGADLRSVQELLGHSNLS STQIYTHVSKEMLRNTYMSHHPRAFKKN*" /label="codV CDS" gene 1566789..1567703 /gene="codV" /locus_tag="BSU_16140" /old_locus_tag="BSU16140" /label="codV gene" promotor_-35 1566828..1566832 /Source="Nicolas_upshift_promotors" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="promotor_-35" upshifts 1566845 /Source="Nicolas_upshifts" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="upshifts" promotor_-10 1566848..1566867 /Source="Nicolas_upshift_promotors" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="promotor_-10" CDS 1567716..1568261 /gene="clpQ" /locus_tag="BSU_16150" /old_locus_tag="BSU16150" /EC_number="3.4.25.2" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component ATP-dependent protease (N-terminalserine protease)" /protein_id="NP_389497.1" /db_xref="EnsemblGenomes-Gn:BSU16150" /db_xref="EnsemblGenomes-Tr:CAB13488" /db_xref="GOA:P39070" /db_xref="InterPro:IPR001353" /db_xref="InterPro:IPR022281" /db_xref="InterPro:IPR023333" /db_xref="InterPro:IPR029055" /db_xref="PDB:1YYF" /db_xref="PDB:2Z3A" /db_xref="PDB:2Z3B" /db_xref="SubtiList:BG10966" /db_xref="UniProtKB/Swiss-Prot:P39070" /translation="MSSFHATTIFAVQHKGRSAMSGDGQVTFGQAVVMKHTARKVRKL FNGKVLAGFAGSVADAFTLFEKFEAKLEEYNGNLKRAAVELAKEWRSDKVLRKLEAML IVMNQDTLLLVSGTGEVIEPDDGILAIGSGGNYALAAGRALKKHAGESMSASEIARAA LETAGEICVYTNDQIILEELE*" /label="clpQ CDS" gene 1567716..1568261 /gene="clpQ" /locus_tag="BSU_16150" /old_locus_tag="BSU16150" /label="clpQ gene" CDS 1568278..1569681 /gene="clpY" /locus_tag="BSU_16160" /old_locus_tag="BSU16160" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component ATP-dependent protease (ATPase andchaperone)" /protein_id="NP_389498.1" /db_xref="EnsemblGenomes-Gn:BSU16160" /db_xref="EnsemblGenomes-Tr:CAB13489" /db_xref="GOA:P39778" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004491" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10967" /db_xref="UniProtKB/Swiss-Prot:P39778" /translation="MEKKPLTPRQIVDRLDQYIVGQQNAKKAVAVALRNRYRRSLLDE KLKDEVVPKNILMMGPTGVGKTEIARRIAKLSGAPFIKIEATKFTEVGYVGRDVESMV RDLVETSVRLIKEEKMNEVKEQAEENANKRIVRLLVPGKKKQSGVKNPFEMFFGGSQP NGEDEAESQEEANIEEKRKRMAHQLALGELEDYYVTVEVEEQQPSMFDMLQGSGMEQM GMNMQDALSGLMPKKKKRRKMTVREARKVLTNEEASKLIDMDEVGQEAVQRAEESGII FIDEIDKIAKNGGASSSADVSREGVQRDILPIVEGSTVVTKYGSVKTDHVLFIAAGAF HMAKPSDLIPELQGRFPIRVELNKLTVDDFVRILVEPDNALLKQYQALLQTEGISLEF SDEAIHKIAEVAYHVNQDTDNIGARRLHTILERLLEDLSFEAPDVTMEKITITPQYVE EKLGTIAKNKDLSQFIL*" /label="clpY CDS" gene 1568278..1569681 /gene="clpY" /locus_tag="BSU_16160" /old_locus_tag="BSU16160" /label="clpY gene" CDS 1569721..1570500 /gene="codY" /locus_tag="BSU_16170" /old_locus_tag="BSU16170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9515911, 10094682, 10231480, 10803944, 10809682, 16488888, 17993518, 21856856, 24843172, 26473603, 27596595, 28011634" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9515911, 10094682, 10231480, 10803944, 10809682, 16488888, 17993518, 21856856, 24843172, 26473603, 27596595, 28011634; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator, GTP and BCAA-dependent" /protein_id="NP_389499.1" /db_xref="EnsemblGenomes-Gn:BSU16170" /db_xref="EnsemblGenomes-Tr:CAB13490" /db_xref="GOA:P39779" /db_xref="InterPro:IPR010312" /db_xref="InterPro:IPR013198" /db_xref="InterPro:IPR014154" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2B0L" /db_xref="PDB:2B18" /db_xref="PDB:2GX5" /db_xref="PDB:2HGV" /db_xref="PDB:5LNH" /db_xref="PDB:5LOE" /db_xref="PDB:5LOJ" /db_xref="PDB:5LOO" /db_xref="SubtiList:BG10968" /db_xref="UniProtKB/Swiss-Prot:P39779" /translation="MALLQKTRIINSMLQAAAGKPVNFKEMAETLRDVIDSNIFVVSR RGKLLGYSINQQIENDRMKKMLEDRQFPEEYTKNLFNVPETSSNLDINSEYTAFPVEN RDLFQAGLTTIVPIIGGGERLGTLILSRLQDQFNDDDLILAEYGATVVGMEILREKAE EIEEEARSKAVVQMAISSLSYSELEAIEHIFEELDGNEGLLVASKIADRVGITRSVIV NALRKLESAGVIESRSLGMKGTYIKVLNNKFLIELENLKSH*" /label="codY CDS" gene 1569721..1570500 /gene="codY" /locus_tag="BSU_16170" /old_locus_tag="BSU16170" /label="codY gene" downshifts 1570475 /Source="Nicolas_upshifts" /id="D893" /incds=0 /nref=6 /ntot=130 /MaxReadThrough="5.35492" /MaxDrop="5.90286" /score="-6.99307778" /energy="-4.2" /TU="U1321,U1322" /idTUdmin="U1320" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1570519 /Source="Nicolas_upshifts" /id="D894" /incds=0 /nref=1 /ntot=104 /MaxReadThrough="4.95658" /MaxDrop="4.85551" /score="-6.99307778" /energy="-4.2" /TU="U1321,U1322" /idTUdmin="U1320" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 1570620..1570627 /Source="Nicolas_upshift_promotors" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1570640..1570658 /Source="Nicolas_upshift_promotors" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1570651..1570804 /Source="Nicolas_S_feature" /locus_tag="new_1691049_1691202" /HighExp="C30, GM 90, GM 25, Cold, GM 15, GM 10, MG 150, GM-0.2, LBGstat, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigA" /TUshortPSig="1, 0.994, 0.998" /TUlongSig="SigA, SigA, SigD, SigA, SigA" /TUlongPSig="1, 0.999, 1, 1, 1" /label="S584" upshifts 1570651 /Source="Nicolas_upshifts" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" promotor_-35 1570779..1570786 /Source="Nicolas_upshift_promotors" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1570801..1570820 /Source="Nicolas_upshift_promotors" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1570806 /Source="Nicolas_upshifts" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1570880..1571269 /gene="flgB" /locus_tag="BSU_16180" /old_locus_tag="BSU16180" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1905667, 2129540, 2181149, 9657996, 17850253, 25843804; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar component of cell-proximal portion of basal-body rod" /protein_id="NP_389500.1" /db_xref="EnsemblGenomes-Gn:BSU16180" /db_xref="EnsemblGenomes-Tr:CAB13491" /db_xref="GOA:P24500" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR006300" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10237" /db_xref="UniProtKB/Swiss-Prot:P24500" /translation="MSLFSGTIQNLENALSRADIKQKVITNNIANIDTPNYKAKKVSF QNLLDQESSRLEAIKTDYRHVDFSDTDSNYSIVASGDTSYQQNGNNVDVDKEMTELAQ NQINYQALVERMNGKFNSLKTVLTGGK*" /label="flgB CDS" gene 1570880..1571269 /gene="flgB" /locus_tag="BSU_16180" /old_locus_tag="BSU16180" /label="flgB gene" CDS 1571269..1571721 /gene="flgC" /locus_tag="BSU_16190" /old_locus_tag="BSU16190" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1905667, 2129540, 2181149, 9657996; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar component of cell-proximal portion of basal-body rod" /protein_id="NP_389501.1" /db_xref="EnsemblGenomes-Gn:BSU16190" /db_xref="EnsemblGenomes-Tr:CAB13492" /db_xref="GOA:P24501" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR006299" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10238" /db_xref="UniProtKB/Swiss-Prot:P24501" /translation="MTAFHSLNVSASALTAQRVRMDVVSSNLANMDTTRAKQVNGEWV PYRRKMVSLQSKGESFSSILNSQMSGSGNAGNGVKVSKITEDDSDFNLVYDPTDPDAN AEGYVQKPNVDPLKEMVDLVSSTRSYEANVTAMNATKGMLMKALEIGK*" /label="flgC CDS" gene 1571269..1571721 /gene="flgC" /locus_tag="BSU_16190" /old_locus_tag="BSU16190" /label="flgC gene" CDS 1571732..1572052 /gene="fliE" /locus_tag="BSU_16200" /old_locus_tag="BSU16200" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11133968, 1551848, 1905667, 2544561, 9161424, 11133968, 15136044; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar basal body protein" /protein_id="NP_389502.1" /db_xref="EnsemblGenomes-Gn:BSU16200" /db_xref="EnsemblGenomes-Tr:CAB13493" /db_xref="GOA:P24502" /db_xref="InterPro:IPR001624" /db_xref="SubtiList:BG10239" /db_xref="UniProtKB/Swiss-Prot:P24502" /translation="MINAISPFQVQNTQNTQNATNQVNNSQKTDSSNQTSFSELLKNS ISSLNESQVASDNMTNALAAGKDVNLDEVMIAAQKASISLTAATEFRNKAVEAYQEIM RMQM*" /label="fliE CDS" gene 1571732..1572052 /gene="fliE" /locus_tag="BSU_16200" /old_locus_tag="BSU16200" /label="fliE gene" downshifts complement(1572047) /Source="Nicolas_upshifts" /id="D895" /incds=0 /nref=1 /ntot=83 /MaxReadThrough="1.38909" /MaxDrop="2.66249" /score="0.0645368779" /energy="-7.4" /TU="NA" /idTUdmin="U1325" /TUdmin=2684 /isTUend="FALSE" /label="downshifts" CDS 1572098..1573708 /gene="fliF" /locus_tag="BSU_16210" /old_locus_tag="BSU16210" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1551848, 1905667, 2544561, 9161424, 11133968, 22670715, 24970213, 28089452; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar basal-body M-ring protein" /protein_id="NP_389503.1" /db_xref="EnsemblGenomes-Gn:BSU16210" /db_xref="EnsemblGenomes-Tr:CAB13494" /db_xref="GOA:P23447" /db_xref="InterPro:IPR000067" /db_xref="InterPro:IPR006182" /db_xref="InterPro:IPR013556" /db_xref="InterPro:IPR021157" /db_xref="SubtiList:BG10240" /db_xref="UniProtKB/Swiss-Prot:P23447" /translation="MNRTLMQMKNKTSEFWKNRSKLQKILMVSALAAIIIIGIIISVF ASNSKMAPLYKDLSAEEAGQIKEELDAKKVPNELSNGGTVISVPEDQVDSLKVQMAAE GLPKTGSIDYSFFGQNAGFGLTDNEFDMVKVKATQTELSNLINEMDGIKNSKVMINLP KDAVFVGEEQSAASASIVLQIQPGYTLDQSQINGLYHLVSKSVPNLKEDNIVIMDQNS TYYDKSDSDAGSYADSYSSQQGIKSQVEKDIQKHVQSLLGTMMGQDKVVVSVTADIDF TKENRTEDIVEPVDKENMEGIAVSAEKVSETYQGDGAANGGTAGTGEEDVTNYKADGE NTESGNYEKNSNKINYEVNRIHKEIAESPYKVRDLGIQVMVEPPDAKNTASLSTERQD DIQKILSTVVRTSLDKDETQNQNLSDADINNKIVVSVQPFDGKVNLDTNTEESSGIPL WAYIVGGVLIAAIIVLIIMLIRKKRAQEDEFEEYEYEVPQEPINLPDINEEENETAES VRRKQLEKMAKDKPEDFAKLLRSWLAED*" /label="fliF CDS" gene 1572098..1573708 /gene="fliF" /locus_tag="BSU_16210" /old_locus_tag="BSU16210" /label="fliF gene" CDS 1573721..1574737 /gene="fliG" /locus_tag="BSU_16220" /old_locus_tag="BSU16220" /function="16.5: Explore" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1551848, 1905667, 2544561, 9161424, 10440379, 11133968, 28089452; Product type s : structure" /codon_start=1 /transl_table=11 /product="flagellar motor switching and energizing component" /protein_id="NP_389504.1" /db_xref="EnsemblGenomes-Gn:BSU16220" /db_xref="EnsemblGenomes-Tr:CAB13495" /db_xref="GOA:P23448" /db_xref="InterPro:IPR000090" /db_xref="InterPro:IPR011002" /db_xref="InterPro:IPR023087" /db_xref="InterPro:IPR028263" /db_xref="InterPro:IPR032779" /db_xref="SubtiList:BG10241" /db_xref="UniProtKB/Swiss-Prot:P23448" /translation="MARRDQDKLTGKQKAAILMISLGLDVSASVYKHLTDEEIERLTL EISGVRSVDHQKKDEIIEEFHNIAIAQDYISQGGLSYARQVLEKALGEDKAENILNRL TSSLQVKPFDFARKAEPEQILNFIQQEHPQTMALILSYLDPVQAGQILSELNPEVQAE VARRIAVMDRTSPEIINEVERILEQKLSSAFTQDYTQTGGIEAVVEVLNGVDRGTEKT ILDSLEIQDPDLAEEIKKRMFVFEDIVTLDNRAIQRVIRDVENDDLLLSLKVASEEVK EIVFNNMSQRMVETFKEEMEFMGPVRLKDVEEAQSRIVSIVRKLEEAGEIVIARGGGD DIIV*" /label="fliG CDS" gene 1573721..1574737 /gene="fliG" /locus_tag="BSU_16220" /old_locus_tag="BSU16220" /label="fliG gene" S_feature 1574738..1574855 /Source="Nicolas_S_feature" /locus_tag="new_1695136_1695253" /HighExp="Lbstat, C90, M0t90, M40t90, Lbtran, C30, LPhT, GM 90, M40t45, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigA" /TUshortPSig="0.998, 1, 0.998" /TUlongSig="SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.994, 1, 0.999, 1, 1, 1" /label="S585" promotor_no_box complement(1574801..1574901) /Source="Nicolas_upshift_promotors" /id="U1325" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.937062937062937" /psig="0.00999000999001" /xcortree=81 /SigmaFactorBS="ttgcctgctcagaaatccggtcagcttcctctttcactcggg ccataagcgcctccgggttctcttcagcctgcaaaaggtgagaatgatcaatacgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1574841) /Source="Nicolas_upshifts" /id="U1325" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.937062937062937" /psig="0.00999000999001" /xcortree=81 /SigmaFactorBS="ttgcctgctcagaaatccggtcagcttcctctttcactcggg ccataagcgcctccgggttctcttcagcctgcaaaaggtgagaatgatcaatacgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1574856..1575482 /gene="fliH" /locus_tag="BSU_16230" /old_locus_tag="BSU16230" /function="16.6: Maintain" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1828465, 12217691, 16522800, 17002279, 26916245; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar export apparatus subunit of cytoplasmic ATPase" /protein_id="NP_389505.2" /db_xref="EnsemblGenomes-Gn:BSU16230" /db_xref="EnsemblGenomes-Tr:CAB13496" /db_xref="GOA:P23449" /db_xref="InterPro:IPR018035" /db_xref="InterPro:IPR022524" /db_xref="SubtiList:BG10242" /db_xref="UniProtKB/Swiss-Prot:P23449" /translation="MARVKEEADRISEQANSHIENIRRQIEQEKNDWAAEKQKLIEEA KAEGFEQGVALGKAEAMKQYAELIGQANSITEMSRKAVEDKLEDANEEIVELAVALAK KVWQQKSDDKEAFLLLVQQVINEVKEYDDISIYVDPYYYETIFQQKDEIQQLLYKECR LGIYADEKAQKGTCYIETPFGRVDASVDTQLMQLKDKLLTALEAGAAE*" /label="fliH CDS" gene 1574856..1575482 /gene="fliH" /locus_tag="BSU_16230" /old_locus_tag="BSU16230" /label="fliH gene" CDS 1575479..1576795 /gene="fliI" /locus_tag="BSU_16240" /old_locus_tag="BSU16240" /EC_number="3.6.3.14" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12787361, 16113269, 16780875, 17002279, 26916245; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="flagellar-specific ATPase subunit of export apparatus" /protein_id="NP_389506.2" /db_xref="EnsemblGenomes-Gn:BSU16240" /db_xref="EnsemblGenomes-Tr:CAB13497" /db_xref="GOA:P23445" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR000225" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004100" /db_xref="InterPro:IPR005714" /db_xref="InterPro:IPR020003" /db_xref="InterPro:IPR022425" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032463" /db_xref="SubtiList:BG10243" /db_xref="UniProtKB/Swiss-Prot:P23445" /translation="MKTQSLIDCIEMTDSYKRYGKVKRVIGLMIESKGPASSIGDLCL IYAKGQSGKVIKAEVVGFQEENILLMPYLEAASIAPGSIVEATGESLRVKVGTGLIGQ VIDAFGEPLDGKLLPKGLSPVSTEQSPPNPMKRPPIREKMGVGVRSIDSLLTVGKGQR IGIFAGSGVGKSTLMGMIAKQTEADLNVIALVGERGREVREFIEKDLGKEGLKRSIVV VATSDQPALMRLKAAYTATAIAEYFRDKGQNVMFMMDSVTRVAMAQREIGLAAGEPPT TKGYTPSVFAILPRLLERTGANEHGTITAFYTVLVDGDDMNEPIADTVRGILDGHIVL DRALANKGQFPAVNVLKSISRVMSNISTKQHLDAANKFRELLSTYQNSEDLINIGAYK RGSSREIDEAIQFYPQLIQFLKQGTDEPALLEESIAALTSLTGNEE*" /label="fliI CDS" gene 1575479..1576795 /gene="fliI" /locus_tag="BSU_16240" /old_locus_tag="BSU16240" /label="fliI gene" CDS 1576798..1577241 /gene="fliJ" /locus_tag="BSU_16250" /old_locus_tag="BSU16250" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17088562, 26916245, 26984495, 27647891; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar synthesis rod subunit of export ATPase" /protein_id="NP_389507.1" /db_xref="EnsemblGenomes-Gn:BSU16250" /db_xref="EnsemblGenomes-Tr:CAB13498" /db_xref="GOA:P20487" /db_xref="InterPro:IPR012823" /db_xref="SubtiList:BG10245" /db_xref="UniProtKB/Swiss-Prot:P20487" /translation="MAYQFRFQKLLELKENEKDQSLSEYQQSVSEFENVAEKLYENMS KKELLEQNKEKKLKSGMSVQEMRHYQQFVSNLDNTIYHYQKLVIMKRNQMNQKQEILT EKNIEVKKFEKMREKQFKMFALEDKAAEMKEMDDISIKQFMIQGH*" /label="fliJ CDS" gene 1576798..1577241 /gene="fliJ" /locus_tag="BSU_16250" /old_locus_tag="BSU16250" /label="fliJ gene" CDS 1577253..1577867 /gene="ylxF" /locus_tag="BSU_16260" /old_locus_tag="BSU16260" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17586671, 22307758; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative kinesin-like protein" /protein_id="NP_389508.2" /db_xref="EnsemblGenomes-Gn:BSU16260" /db_xref="EnsemblGenomes-Tr:CAB13499" /db_xref="GOA:P23454" /db_xref="InterPro:IPR006668" /db_xref="InterPro:IPR011002" /db_xref="SubtiList:BG10246" /db_xref="UniProtKB/Swiss-Prot:P23454" /translation="MSGKKKESGKFRSVLLIIILPLMFLLIAGGIVLWAAGINVLKPI QDAAAKTPVLKELVPETENKKGAASSKDSSNTAALEKTIKDQKSEISILNKDLETSKS EIDRLNQKIRSLEKTAEDQKKSSEDHTEGSADSKASSENDKVISVYKSMDSGKAAKII AQLKEQEALKILNGLSKKQLADILAKMTPEQAATYTEKIAASQE*" /label="ylxF CDS" gene 1577253..1577867 /gene="ylxF" /locus_tag="BSU_16260" /old_locus_tag="BSU16260" /label="ylxF gene" CDS 1577880..1579343 /gene="fliK" /locus_tag="BSU_16270" /old_locus_tag="BSU16270" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16630628, 16949608, 28557186; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar hook-length control protein (ruler)" /protein_id="NP_389509.2" /db_xref="EnsemblGenomes-Gn:BSU16270" /db_xref="EnsemblGenomes-Tr:CAB13500" /db_xref="GOA:P23451" /db_xref="InterPro:IPR001635" /db_xref="InterPro:IPR021136" /db_xref="SubtiList:BG10247" /db_xref="UniProtKB/Swiss-Prot:P23451" /translation="MKLLELAGPLLQTTTGSAAKNMKSSQGVFQNWLMSEAGLKELSE QGKGTPNSEDQLLADALKKIGEWLNASPEDQDKQNADLLQTLSKLTGKQLDANALQML QNLLQAVESKMSGGTDQLLTETEKIFSEAKTALSANDSASDINGALKSDKEQSNQENE VSEPAKELIYIQMFISQLVEGNKLTDLGNGNEAHAIYQNGDQFLSALEKKGVSQQLIQ DLKQQIFTKAESSSKLYSMTASELKSFQSLMDQMSMLPQKGTKEWSLAESQLKAFLLS KSSESSQDFGKSVLTPLSQSSSSKNASDVSGSIQPVDSKSGLQMLFSGYRGIGGVQTL DLQQMSSDIPNAETKTVADQVINAWKQMKYTPFGRSTGSFTIRLNPEHLGFVTIKLTN ENGMFQSKIIASSQSAKELLEQHLPQLKQSLPNMAVQIDRFTLPVQSGDQPIYGQLAD EQKQQQEGQRQQRQKKQSNDFGDLLDEVSMVEMEEEE*" /label="fliK CDS" gene 1577880..1579343 /gene="fliK" /locus_tag="BSU_16270" /old_locus_tag="BSU16270" /label="fliK gene" CDS 1579340..1579762 /gene="flgD" /locus_tag="BSU_16280" /old_locus_tag="BSU16280" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8157595, 14563871, 24748615; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar hook capping protein" /protein_id="NP_389510.1" /db_xref="EnsemblGenomes-Gn:BSU16280" /db_xref="EnsemblGenomes-Tr:CAB13501" /db_xref="GOA:P23455" /db_xref="InterPro:IPR005648" /db_xref="SubtiList:BG10248" /db_xref="UniProtKB/Swiss-Prot:P23455" /translation="MTSISSEYKLPEKTNTVSTNNSSLGKDEFLKILMTQVQNQDPLN PIDDKEFISQMATFSSLEQMMNLNTTMTQFVENQDPFTTYVDWMGKEVSWTDGKSATD KTGTVSSVKHFKGNYYLVLDDGTEISPANVMSVGQSSK*" /label="flgD CDS" gene 1579340..1579762 /gene="flgD" /locus_tag="BSU_16280" /old_locus_tag="BSU16280" /label="flgD gene" CDS 1579784..1580578 /gene="flgE" /locus_tag="BSU_16290" /old_locus_tag="BSU16290" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15502333, 15510139, 27759043, 28120828, 28429800; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar hook protein" /protein_id="NP_389511.2" /db_xref="EnsemblGenomes-Gn:BSU16290" /db_xref="EnsemblGenomes-Tr:CAB13502" /db_xref="GOA:P23446" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR012836" /db_xref="InterPro:IPR019776" /db_xref="InterPro:IPR020013" /db_xref="SubtiList:BG10249" /db_xref="UniProtKB/Swiss-Prot:P23446" /translation="MLRSLYSGISGMKNFQTKLDVIGNNIANVNTVGFKKSRVTFKDM VSQTIAGGSAAGATIGGTNSKQIGLGSSSGTIDTIHSTSATQSTGRTLDLAIDGDGYF RIDTGDGTAYTRAGNFYLDNTGTLVTGDGYHVLNMNGGTIKIPTDAQSFSIGSDGKVS IVDAEGKTQDGGQIGIVTFANSDGLDKIGSNLYRESLNSGTASAANQPGDGGTGALKS GFLEMSNVDLTDEFTEMIVAQRGFQSNSKIITTSDEILQELVNLKR*" /label="flgE CDS" gene 1579784..1580578 /gene="flgE" /locus_tag="BSU_16290" /old_locus_tag="BSU16290" /label="flgE gene" CDS 1580618..1580833 /gene="swrD" /locus_tag="BSU_16299" /old_locus_tag="BSU16299" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9168127, 29061663" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9168127, 29061663; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar power transducer required for swarming" /protein_id="YP_003097728.1" /db_xref="EnsemblGenomes-Gn:BSU16299" /db_xref="EnsemblGenomes-Tr:CAX52619" /db_xref="InterPro:IPR009384" /db_xref="UniProtKB/Swiss-Prot:C0H412" /translation="MIKVTRLNGQPFTLNALFIEQIECFPDTTITLSNGKKFVVKEDE EAVLEKIAAFYRKIQIFAMDQGIEEPE*" /label="swrD CDS" gene 1580618..1580833 /gene="swrD" /locus_tag="BSU_16299" /old_locus_tag="BSU16299" /label="swrD gene" CDS 1580830..1581252 /gene="fliL" /locus_tag="BSU_16300" /old_locus_tag="BSU16300" /function="16.5: Explore" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10439416, 12787361, 16166542, 23264580, 25714720, 28717192; Product type f : factor" /codon_start=1 /transl_table=11 /product="flagellar basal-body (stator) associated protein" /protein_id="NP_389512.1" /db_xref="EnsemblGenomes-Gn:BSU16300" /db_xref="EnsemblGenomes-Tr:CAB13503" /db_xref="GOA:P23452" /db_xref="InterPro:IPR005503" /db_xref="SubtiList:BG10250" /db_xref="UniProtKB/Swiss-Prot:P23452" /translation="MKKKLMIILLIILIVIGALGAAAYFVLGGKSEKSEAKKSIDEIV ASSVDVEEITTNLKSDNIIRLAIKLETDSDKSKEELEKRDFQVKDAVISLLADTNADQ IEGDKGKETFKKELKDKINSYLQEGKVEKVYITSFNLQ*" /label="fliL CDS" gene 1580830..1581252 /gene="fliL" /locus_tag="BSU_16300" /old_locus_tag="BSU16300" /label="fliL gene" CDS 1581286..1582284 /gene="fliM" /locus_tag="BSU_16310" /old_locus_tag="BSU16310" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7787061, 16547037, 16796690, 16882724, 17015643, 17050923, 22720735, 28625846; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="flagellar motor switching and energizing component" /protein_id="NP_389513.1" /db_xref="EnsemblGenomes-Gn:BSU16310" /db_xref="EnsemblGenomes-Tr:CAB13504" /db_xref="GOA:P23453" /db_xref="InterPro:IPR001543" /db_xref="InterPro:IPR001689" /db_xref="InterPro:IPR028976" /db_xref="InterPro:IPR036429" /db_xref="SubtiList:BG10251" /db_xref="UniProtKB/Swiss-Prot:P23453" /translation="MSGEVLSQNEIDALLSAISTGEMDAEELKKEEKEKKVKVYDFKR ALRFSKDQIRSLTRIHDNFARLLTTHFSAQLRTYIHISVSSVDQVPYEEFIRSIPNMT ILNLFDVHPMEGRIMMEVNPTIAYTMMDRVMGGIGISHNKVDSLTEIETKIISNLFEN ALGNYKEAWQSIADIEPEMTEFEVNPQFVQMVSPNETVVVISLNTQIGEISGVINLCI PHIVLEPLIPKLSVHYWMQSDRNEPKPEETKSLEKRIMTAQIPVVAELGTSELTIEEF LSLEVGDCITLDKSVTDPLTVLVGDKPKFLGQAGRVNRKQAVQILDHDIRGEQDGE*" /label="fliM CDS" gene 1581286..1582284 /gene="fliM" /locus_tag="BSU_16310" /old_locus_tag="BSU16310" /label="fliM gene" CDS 1582274..1583410 /gene="fliY" /locus_tag="BSU_16320" /old_locus_tag="BSU16320" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12920116, 16547037, 16796690, 16882724, 17015643, 17050923, 23226535, 23532838, 26195616" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12920116, 16547037, 16796690, 16882724, 17015643, 17050923, 23226535, 23532838, 26195616; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="flagellar motor switching and energizing phosphatase" /protein_id="NP_389514.1" /db_xref="EnsemblGenomes-Gn:BSU16320" /db_xref="EnsemblGenomes-Tr:CAB13505" /db_xref="GOA:P24073" /db_xref="InterPro:IPR001172" /db_xref="InterPro:IPR001543" /db_xref="InterPro:IPR007597" /db_xref="InterPro:IPR012826" /db_xref="InterPro:IPR028976" /db_xref="InterPro:IPR036429" /db_xref="SubtiList:BG10252" /db_xref="UniProtKB/Swiss-Prot:P24073" /translation="MENNRLSQDEIDALLNGTGSTLDEPEIPEVDDLSEMERDAIGEI GNISFGSSATALSTLLNQKVDITTPSVTVIPRSKISDAFPEPYVAIEVNYTEGFSGSN LLVVEQSDAAIIADLMIGGDGKGADPSLGEIHLSAVQEAMNQMMGSAATSMSTVFSKK IDISPPRVELLDVTEEKGTDRIPDDEMLVKVSFNLKVGELIDSSIMQLYPLTFAKDLI SSLMNSESAEEEETVQPEVTYEQPKEPVTPEPRIEPKQQQQPPKRQGTAKKAAPVQVS PVEFSAFDPNEAVQAPIHNLDMLLDIPLSITVELGRTKRSVKEILELSAGSIIELDKL AGEPVDILVNQRIVAKGEVVVIEENFGVRVTDILSQAERINNLK*" /label="fliY CDS" gene 1582274..1583410 /gene="fliY" /locus_tag="BSU_16320" /old_locus_tag="BSU16320" /label="fliY gene" CDS 1583436..1583798 /gene="cheY" /locus_tag="BSU_16330" /old_locus_tag="BSU16330" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10196193, 12864845, 12920116, 14749334, 23226535, 28542702" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10196193, 12864845, 12920116, 14749334, 23226535, 28542702; Product type r : regulator" /codon_start=1 /transl_table=11 /product="regulator of chemotaxis and motility" /protein_id="NP_389515.1" /db_xref="EnsemblGenomes-Gn:BSU16330" /db_xref="EnsemblGenomes-Tr:CAB13506" /db_xref="GOA:P24072" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG10258" /db_xref="UniProtKB/Swiss-Prot:P24072" /translation="MAHRILIVDDAAFMRMMIKDILVKNGFEVVAEAENGAQAVEKYK EHSPDLVTMDITMPEMDGITALKEIKQIDAQARIIMCSAMGQQSMVIDAIQAGAKDFI VKPFQADRVLEAINKTLN*" /label="cheY CDS" gene 1583436..1583798 /gene="cheY" /locus_tag="BSU_16330" /old_locus_tag="BSU16330" /label="cheY gene" CDS 1583813..1584472 /gene="fliZ" /locus_tag="BSU_16340" /old_locus_tag="BSU16340" /function="16.3: Control" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10791024, 1597417, 16513753, 24204316; Product type r: regulator" /codon_start=1 /transl_table=11 /product="flagellar regulatory protein" /protein_id="NP_389516.1" /db_xref="EnsemblGenomes-Gn:BSU16340" /db_xref="EnsemblGenomes-Tr:CAB13507" /db_xref="GOA:P35536" /db_xref="InterPro:IPR022781" /db_xref="SubtiList:BG10259" /db_xref="UniProtKB/Swiss-Prot:P35536" /translation="MKKSQYFIVFICFFVLFSVHPIAAAAADSDNSTVNEWFQKKDEK TADQSEQKKEKTTKTADETEGAAAPSVSAFDFVKMIFALLFVIVLIYGLVKLMNKRNR LLKPFQYVENIGGTSVGQNRSIQLIKVGKSVLVVGVGETIQLLKEIEDEKEIEVILSQ HEEAMSSKIEWQKFVKPLKSSEHQPQQKLPSFSKALKEQLEELKQNRSEGKKKGPRHH E*" /label="fliZ CDS" gene 1583813..1584472 /gene="fliZ" /locus_tag="BSU_16340" /old_locus_tag="BSU16340" /label="fliZ gene" CDS 1584465..1585130 /gene="fliP" /locus_tag="BSU_16350" /old_locus_tag="BSU16350" /function="16.3: Control" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15516571, 15849754, 16850406, 22720735, 26244495, 27855178, 28559296; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389517.1" /db_xref="EnsemblGenomes-Gn:BSU16350" /db_xref="EnsemblGenomes-Tr:CAB13508" /db_xref="GOA:P35528" /db_xref="InterPro:IPR005837" /db_xref="InterPro:IPR005838" /db_xref="SubtiList:BG10260" /db_xref="UniProtKB/Swiss-Prot:P35528" /translation="MNEFINIFSSSDPENVSSTVKLLLLLTVFSVAPGILILMTCFTR IVIVLSFVRTSLATQSMPPNQVLIGLALFLTFFIMAPTFSEINKEALTPLMDNKISLD EAYTKAEEPIKEFMSKHTRQKDLALFMNYAKMDKPESLKDIPLTTMVPAFAISELKTA FQIGFMIFIPFLIIDMVVASVLMSMGMMMLPPVMISLPFKILLFVLVDGWYLIVKSLL QSF*" /label="fliP CDS" gene 1584465..1585130 /gene="fliP" /locus_tag="BSU_16350" /old_locus_tag="BSU16350" /label="fliP gene" CDS 1585145..1585414 /gene="fliQ" /locus_tag="BSU_16360" /old_locus_tag="BSU16360" /function="16.5: Explore" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10234819, 15516571, 27855178; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389518.1" /db_xref="EnsemblGenomes-Gn:BSU16360" /db_xref="EnsemblGenomes-Tr:CAB13509" /db_xref="GOA:P35535" /db_xref="InterPro:IPR002191" /db_xref="InterPro:IPR006305" /db_xref="SubtiList:BG10261" /db_xref="UniProtKB/Swiss-Prot:P35535" /translation="MSSEFVISMAEKAVYVTLMISGPLLAIALLVGLIVSIFQATTQI QEQTLAFIPKIVAVLLALIFFGPWMLSTILSFTTELFSNLNRFAG*" /label="fliQ CDS" gene 1585145..1585414 /gene="fliQ" /locus_tag="BSU_16360" /old_locus_tag="BSU16360" /label="fliQ gene" CDS 1585422..1586201 /gene="fliR" /locus_tag="BSU_16370" /old_locus_tag="BSU16370" /function="16.5: Explore" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15060055, 15516571, 15849754, 16850406, 28771474; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389519.2" /db_xref="EnsemblGenomes-Gn:BSU16370" /db_xref="EnsemblGenomes-Tr:CAB13510" /db_xref="GOA:P35537" /db_xref="InterPro:IPR002010" /db_xref="InterPro:IPR006303" /db_xref="SubtiList:BG10262" /db_xref="UniProtKB/Swiss-Prot:P35537" /translation="MNSIIDLFPAFLLVFIRISAFFVTIPLFGHRNVPAVHRIGFAFF LAVICFSTIDKPPSLEIDEHYMLLAFKEALVGLCLGLIAYMMIAAVQIAGSFIDFQMG FSIANVIDPQTGAQSPLIGQFIYTMALLFMLSVNAHHLLLDGIYYSFQYISVDQAFPN FGDEKFAYFIAKSFNAMFIIAFQMSAPVVASLFLVDLALGIVARTVPQLNVFVVGLPL KIAVSFIMLIVCMSVIFVVVRNVFSLTIETMRNLLALVGVS*" /label="fliR CDS" gene 1585422..1586201 /gene="fliR" /locus_tag="BSU_16370" /old_locus_tag="BSU16370" /label="fliR gene" CDS 1586201..1587283 /gene="flhB" /locus_tag="BSU_16380" /old_locus_tag="BSU16380" /function="16.1: Circulate" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10234819, 16949608, 17050924, 17067800, 28557186, 28771466; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389520.1" /db_xref="EnsemblGenomes-Gn:BSU16380" /db_xref="EnsemblGenomes-Tr:CAB13511" /db_xref="GOA:P35538" /db_xref="InterPro:IPR006135" /db_xref="InterPro:IPR006136" /db_xref="InterPro:IPR029025" /db_xref="SubtiList:BG10543" /db_xref="UniProtKB/Swiss-Prot:P35538" /translation="MKLRVDLQFFAGEKTEKATPKKRKDTRKKGQVAKSSDVNTAVSL LVIFLSLIAIGPYMRDRLLSFIETFYTESLTMKLSESNVHTLFVSLLKDMGMILAPIL LVALVAGVVSNYMQVGFLFSAEVIQPKLEKLDPIKGFKRIYSMRAIVELIKSILKIVV VGFAAFAVLWLHYGEILRLPLLTPEEALSFVSKLTLWMGLSGAGALLILAGLDYLYQR FDYEKNIKMSKQDIKDEYKKSEGDPIIKSKIKQRQREMAMRRMMQEVPKADVIITNPT HYAIALKYDEEKMDAPYIVAKGVDHLALKIRKIAKEHDVMMVENRPLARALYDQVEID QAVPEEFFKVLAEILAYVYKTKQKVY*" /label="flhB CDS" gene 1586201..1587283 /gene="flhB" /locus_tag="BSU_16380" /old_locus_tag="BSU16380" /label="flhB gene" CDS 1587316..1589349 /gene="flhA" /locus_tag="BSU_16390" /old_locus_tag="BSU16390" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10234819, 15516571, 20534509, 28771466" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10234819, 15516571, 20534509, 28771466; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389521.2" /db_xref="EnsemblGenomes-Gn:BSU16390" /db_xref="EnsemblGenomes-Tr:CAB13512" /db_xref="GOA:P35620" /db_xref="InterPro:IPR001712" /db_xref="InterPro:IPR006301" /db_xref="InterPro:IPR025505" /db_xref="PDB:3MIX" /db_xref="SubtiList:BG10542" /db_xref="UniProtKB/Swiss-Prot:P35620" /translation="MSTRDLSVLISVVLIVAMLVIPFPPWLLSILIIINISLALIVLL TTMNMQEALQFSIFPSLLLLLTLFRLGLNVSTTRSILSHGEGGKVVETFGNFVVGGNV LVGLVVFIILIIIQFIVITKGAERVSEVAARFTLDAMPGKQMSIDADLNAGMITEQEA KHRREKVAREADFYGAMDGASKFVKGDAIAGIIIVMINIIFGIVIGMLQQGMSIQEAA SHFTMLTVGDGIVSQIPALLISTATGIVVTRAASEGNLGHDITGQLFAYPKLLYVAAA TIMLLGIFTPIGILLTGPLAGLLAFGAYTLSKSGKEKEEVDEILEEEAEVDELKSPES VVQLLHIDPIEFEFGYGLIPLADANQGGDLLDRIVMIRRQLALELGLVIPVVRIRDNI ALQPNEYRLKIKGNEVAKGELLLDHYLAMSPTPEDDLIEGIETVEPSFGLPAKWISEA VKDEADMLGYTVVDPASVVSTHITEKIKQHAHELIGRQETKQLIDHLKESYPVLVEEV TPNPLSVGDIQKVLAKLLKEKVSIRNLVTIFETLADYGKLTTDSDLLTEYTRQALAKQ ITAQFAKENEVLKVVTCSGRVEKAIADGVQQTEHGNYLSLEPDISESIVRSVAKEAEQ LSLRQETAILLCSPPVRMYVKQLLERYFPDLPVLSYNELEANVEVQSIGVVDI*" /label="flhA CDS" gene 1587316..1589349 /gene="flhA" /locus_tag="BSU_16390" /old_locus_tag="BSU16390" /label="flhA gene" CDS 1589349..1590449 /gene="flhF" /locus_tag="BSU_16400" /old_locus_tag="BSU16400" /function="16.5: Explore" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1447978, 15317803, 16980502, 17565194, 17699634, 26195616, 27807433; Product type t: transporter" /codon_start=1 /transl_table=11 /product="GTPase involved in the export of flagella and number regulation" /protein_id="NP_389522.1" /db_xref="EnsemblGenomes-Gn:BSU16400" /db_xref="EnsemblGenomes-Tr:CAB13513" /db_xref="GOA:Q01960" /db_xref="InterPro:IPR000897" /db_xref="InterPro:IPR020006" /db_xref="InterPro:IPR027417" /db_xref="PDB:2PX0" /db_xref="PDB:2PX3" /db_xref="PDB:3SYN" /db_xref="SubtiList:BG10544" /db_xref="UniProtKB/Swiss-Prot:Q01960" /translation="MKIKKFTAASMQEAALLIRKELGNEAVILNSKKIKKRKWFGLVN KPAVEVIAVLDQDFLEKKTPQKAAEPKQTLKTPVSSPKIEERTYPPQIPAQQELGDFS AYQSVLPEPLRKAEKLLQETGIKESTKTNTLKKLLRFSVEAGGLTEENVVGKLQEILC DMLPSADKWQEPIHSKYIVLFGSTGAGKTTTLAKLAAISMLEKHKKIAFITTDTYRIA AVEQLKTYAELLQAPLEVCYTKEEFQQAKELFSEYDHVFVDTAGRNFKDPQYIDELKE TIPFESSIQSFLVLSATAKYEDMKHIVKRFSSVPVNQYIFTKIDETTSLGSVFNILAE SKIGVGFMTNGQNVPEDIQTVSPLGFVRMLCR*" /label="flhF CDS" gene 1589349..1590449 /gene="flhF" /locus_tag="BSU_16400" /old_locus_tag="BSU16400" /label="flhF gene" promotor_-10 complement(1590326..1590345) /Source="Nicolas_upshift_promotors" /id="U1326" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1367 /SigmaFactorBS="gcacattctggccgttagtcataaaCCCGACACCTatttttg attctgCCAGTATATTAAATACAGAAcctaaggaagtcgtttcatctattttcgtaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1590333) /Source="Nicolas_upshifts" /id="U1326" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1367 /SigmaFactorBS="gcacattctggccgttagtcataaaCCCGACACCTatttttg attctgCCAGTATATTAAATACAGAAcctaaggaagtcgtttcatctattttcgtaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1590359..1590368) /Source="Nicolas_upshift_promotors" /id="U1326" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1367 /SigmaFactorBS="gcacattctggccgttagtcataaaCCCGACACCTatttttg attctgCCAGTATATTAAATACAGAAcctaaggaagtcgtttcatctattttcgtaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1590440..1591336 /gene="flhG" /locus_tag="BSU_16410" /old_locus_tag="BSU16410" /function="16.5: Explore" /function="16.6: Maintain" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15361076, 25733861, 26411371" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15361076, 25733861, 26411371; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="ATPase affecting flagellar basal body localisation and number" /protein_id="NP_389523.1" /db_xref="EnsemblGenomes-Gn:BSU16410" /db_xref="EnsemblGenomes-Tr:CAB13514" /db_xref="GOA:P40742" /db_xref="InterPro:IPR025501" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033756" /db_xref="InterPro:IPR033875" /db_xref="PDB:3SYN" /db_xref="SubtiList:BG10254" /db_xref="UniProtKB/Swiss-Prot:P40742" /translation="MQMNRYDQAATLRAKMEKRERVLPMVYSQKAKTLAVISGKGGVG KSNITLNMALALQDKGKKVLLIDLDIGMGNIDILIGNSSSATIIDVLTDRKPLLQSLS VGPKGLRYISGGTGLDVMFQLDQRKWTFFANELSHALSQFDYVLFDMGAGLSKDQLPF ILSAEDILIITTPEPTAIMDAYSAVKHLVLTENKLSMKVAVNRCRDQKEGLDAFARLS RTIHMFLDVQVQFAGSVSDDVIVSKAVVEQVPFFIKSPQAKASRSVRILADALFEREE TRHKEDKQTFIEKLSSFLMRRA*" /label="flhG CDS" gene 1590440..1591336 /gene="flhG" /locus_tag="BSU_16410" /old_locus_tag="BSU16410" /label="flhG gene" CDS 1591338..1592411 /gene="cheB" /locus_tag="BSU_16420" /old_locus_tag="BSU16420" /EC_number="3.1.1.61" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1738311, 10632876, 12123464, 21515776" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1738311, 10632876, 12123464, 21515776; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis proteins (MCP)-glutamate methylesterase" /protein_id="NP_389524.2" /db_xref="EnsemblGenomes-Gn:BSU16420" /db_xref="EnsemblGenomes-Tr:CAB13515" /db_xref="GOA:Q05522" /db_xref="InterPro:IPR000673" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR008248" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR035909" /db_xref="SubtiList:BG10255" /db_xref="UniProtKB/Swiss-Prot:Q05522" /translation="MIRVLVVDDSAFMRKMISDFLTEEKQIEVIGTARNGEEALKKIE LLKPDVITLDVEMPVMNGTDTLRKIIEIYNLPVIMVSSQTEKGKECTINCLEIGAFDF ITKPSGSISLDLYKIKEQLVERVVAAGLSGKRKRPVSQTVRPEPIVRAVVKPELSKPK PGTGRQIVCIGTSTGGPRALQKVIPKLPKDLNAPVVVVQHMPEGFTASLADRLNHLSD IQVKEAKDGEAALNGCVYIAPGGKNISVIKNSEGLQVVLDNHDTPSRHKPSADYLFRS VGKLTDYEKVAVIMTGMGSDGTAGLKDMLTAGNVKAIAESEESCVVYGMPKAAVKAGL IHEIKHVEDIAASITSCVKKERV*" /label="cheB CDS" gene 1591338..1592411 /gene="cheB" /locus_tag="BSU_16420" /old_locus_tag="BSU16420" /label="cheB gene" CDS 1592417..1594435 /gene="cheA" /locus_tag="BSU_16430" /old_locus_tag="BSU16430" /EC_number="2.7.3.-" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:12094812, 12864845, 12920116, 15451661, 16045621, 21515776, 22355139" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12094812, 12864845, 12920116, 15451661, 16045621, 21515776, 22355139; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="chemotactic two-component sensor histidine kinase" /protein_id="NP_389525.2" /db_xref="EnsemblGenomes-Gn:BSU16430" /db_xref="EnsemblGenomes-Tr:CAB13516" /db_xref="GOA:P29072" /db_xref="InterPro:IPR002545" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004105" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR008207" /db_xref="InterPro:IPR010808" /db_xref="InterPro:IPR035891" /db_xref="InterPro:IPR036061" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036641" /db_xref="InterPro:IPR036890" /db_xref="InterPro:IPR037006" /db_xref="InterPro:IPR037052" /db_xref="SubtiList:BG10256" /db_xref="UniProtKB/Swiss-Prot:P29072" /translation="MDMNQYLDVFIDESKEHLQTCNEKLLLLEKDPTDLQLVHDIFRA AHTLKGMSATMGYTDLAHLTHLLENVLDAIRNGDMEVTSDWLDILFEALDHLETMVQS IIDGGDGKRDISEVSAKLDVNGAHAESAASAEPAEAQSSASDWEYDEFERTVIQEAEE QGFKRYEIKISLNENCMLKAVRVYMVFEKLNEVGEVAKTIPSAEVLETEDFGTDFQVC FLTHQSAEDIEQLINGVSEIEHVEVIQGAPLTSAEKPEESKQEDSPAAAVPAKQEKQK QPAKNDEQAKHSAGGSKTIRVNIDRLDSLMNLFEELVIDRGRLEQIAKELEHNELTET VERMTRISGDLQSIILNMRMVPVETVFNRFPRMIRQLQKELNKKIELSIIGAETELDR TVIDEIGDPLVHLIRNSIDHGIEAPETRLQKGKPESGKVVLKAYHSGNHVFIEVEDDG AGLNRKKILEKALERGVITEKEAETLEDNQIYELIFAPGFSTADQISDISGRGVGLDV VKNKLESLGGSVSVKSAEGQGSLFSIQLPLTLSIISVLLIKLEEETFAIPISSIIETA VIDRKDILQTHDREVIDFRGHIVPVVYLKEEFKIEDTRKDAEQLHIIVVKKGDKPTAF VVDSFIGQQEVVLKSLGDYLTNVFAISGATILGDGEVALIIDCNALII*" /label="cheA CDS" gene 1592417..1594435 /gene="cheA" /locus_tag="BSU_16430" /old_locus_tag="BSU16430" /label="cheA gene" CDS 1594457..1594927 /gene="cheW" /locus_tag="BSU_16440" /old_locus_tag="BSU16440" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12864845, 15451661, 1624415, 8169223, 8169224" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12864845, 15451661, 1624415, 8169223, 8169224; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modulation of CheA activity in response to attractants (chemotaxis)" /protein_id="NP_389526.1" /db_xref="EnsemblGenomes-Gn:BSU16440" /db_xref="EnsemblGenomes-Tr:CAB13517" /db_xref="GOA:P39802" /db_xref="InterPro:IPR002545" /db_xref="InterPro:IPR036061" /db_xref="SubtiList:BG10692" /db_xref="UniProtKB/Swiss-Prot:P39802" /translation="MTAEIKTGEKMIVFMVNGKEYAISVTQVKSIEKWQKPTRVPGVE PYICGVINLRGVVTPVIDLRKRLNLPEYEITDETRIIIIAYRDIEVGWIVDEANDVIT VHESEIESAPEGVQKDTDVSIEQIVKQENRLLNIIDANAVLDKESSQSAVPDQA*" /label="cheW CDS" gene 1594457..1594927 /gene="cheW" /locus_tag="BSU_16440" /old_locus_tag="BSU16440" /label="cheW gene" CDS 1594946..1595575 /gene="cheC" /locus_tag="BSU_16450" /old_locus_tag="BSU16450" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12920116, 14749334, 14993307, 15546616, 16469702, 18990184, 22720735, 23226535" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12920116, 14749334, 14993307, 15546616, 16469702, 18990184, 22720735, 23226535; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="signal terminating phosphatase of CheR-mediated methylation of methyl-accepting chemotaxis proteins (MCPs)" /protein_id="NP_389527.1" /db_xref="EnsemblGenomes-Gn:BSU16450" /db_xref="EnsemblGenomes-Tr:CAB13518" /db_xref="GOA:P40403" /db_xref="InterPro:IPR007597" /db_xref="InterPro:IPR028976" /db_xref="SubtiList:BG10749" /db_xref="UniProtKB/Swiss-Prot:P40403" /translation="MSIFNGIKEEQMDILREVGNIGAGHSASAMAQLLNRKIDMEVPF AKLLSFDELVDFFGGADVPVASIFLRMEGDLTGSMFFIMPFFQAEQFIRELIGNPDFD IEDLGEDHMSSSALHELGNILAGSYLTALADLTKLQLYPSVPEVSLDMFGAVISEGLM ELSQVGEHAIVVDTSIFDQSHQQELKAHMFMLPDYDSFEKLFVALGASL*" /label="cheC CDS" gene 1594946..1595575 /gene="cheC" /locus_tag="BSU_16450" /old_locus_tag="BSU16450" /label="cheC gene" CDS 1595572..1596072 /gene="cheD" /locus_tag="BSU_16460" /old_locus_tag="BSU16460" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15546616, 16469702, 22720735, 23226535" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15546616, 16469702, 22720735, 23226535; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sequence specific deamidase required for methylation of methyl-accepting chemotaxis proteins (MCPs) by CheR" /protein_id="NP_389528.1" /db_xref="EnsemblGenomes-Gn:BSU16460" /db_xref="EnsemblGenomes-Tr:CAB13519" /db_xref="GOA:P40404" /db_xref="InterPro:IPR005659" /db_xref="InterPro:IPR011324" /db_xref="SubtiList:BG10750" /db_xref="UniProtKB/Swiss-Prot:P40404" /translation="MSTTEAVVIKVGIADVKIARFPDTIRTSGLGSCVGLVLYDKEKQ TAGLVHVMLPDSTLSKTAELNRAKYADTAVQTTIDMLIEAGCRKFALKAKLAGGSEMF KFKSTNDLMKIGPRNVLAIKEQLSLFNIPIISEDTGGSSGRTIEFEPKSCMLHIRTVK QGEKTI*" /label="cheD CDS" gene 1595572..1596072 /gene="cheD" /locus_tag="BSU_16460" /old_locus_tag="BSU16460" /label="cheD gene" CDS 1596095..1596859 /gene="sigD" /locus_tag="BSU_16470" /old_locus_tag="BSU16470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2498284, 9648743, 9657996, 11751842, 15033535, 15066026, 15175317, 22329926, 22956758, 25288929, 26170408" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2498284, 9648743, 9657996, 11751842, 15033535, 15066026, 15175317, 22329926, 22956758, 25288929, 26170408; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-28 factor (sigma-D)" /protein_id="NP_389529.1" /db_xref="EnsemblGenomes-Gn:BSU16470" /db_xref="EnsemblGenomes-Tr:CAB13520" /db_xref="GOA:P10726" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR012845" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10751" /db_xref="UniProtKB/Swiss-Prot:P10726" /translation="MQSLNYEDQVLWTRWKEWKDPKAGDDLMRRYMPLVTYHVGRISV GLPKSVHKDDLMSLGMLGLYDALEKFDPSRDLKFDTYASFRIRGAIIDGLRKEDWLPR TSREKTKKVEAAIEKLEQRYLRNVSPAEIAEELGMTVQDVVSTMNEGFFANLLSIDEK LHDQDDGENIQVMIRDDKNVPPEEKIMKDELIAQLAEKIHELSEKEQLVVSLFYKEEL TLTEIGQVLNLSTSRISQIHSKALFKLKNLLEKVIQ*" /label="sigD CDS" gene 1596095..1596859 /gene="sigD" /locus_tag="BSU_16470" /old_locus_tag="BSU16470" /label="sigD gene" promotor_-35 1596869..1596875 /Source="Nicolas_upshift_promotors" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" CDS 1596888..1597391 /gene="swrB" /locus_tag="BSU_16480" /old_locus_tag="BSU16480" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15066026, 15175317, 19202088, 21736639, 26244495" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 15175317, 19202088, 21736639, 26244495; Product type r: regulator" /codon_start=1 /transl_table=11 /product="coupling factor for flagellin transcription and translation" /protein_id="NP_389530.1" /db_xref="EnsemblGenomes-Gn:BSU16480" /db_xref="EnsemblGenomes-Tr:CAB13521" /db_xref="SubtiList:BG10752" /db_xref="UniProtKB/Swiss-Prot:P40405" /translation="MSTLLWLLSFMLHGVLLYAVIILYTRLAAVKETEKQQKQILEET ENTLAAFLLELKEENEKLIENKASSASQSDEESQKSGLQTSETYQERDPVQEAENLPE HIEGLITEVDRREELVNSEVQSFEDQVIELYEQGYSASQIAQKMKSGKTEIELFLKFR SKGVKDS*" /label="swrB CDS" gene 1596888..1597391 /gene="swrB" /locus_tag="BSU_16480" /old_locus_tag="BSU16480" /label="swrB gene" promotor_-10 1596890..1596901 /Source="Nicolas_upshift_promotors" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1596904 /Source="Nicolas_upshifts" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" promotor_-35 1597387..1597393 /Source="Nicolas_upshift_promotors" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1597408..1597427 /Source="Nicolas_upshift_promotors" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1597410..1597534 /Source="Nicolas_S_feature" /locus_tag="new_1717808_1717932" /HighExp="GM 45, GM 15, H2O2, M9-exp, LBGexp, C30, MG 90, GM-0.1, G135, SMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S586" upshifts 1597410 /Source="Nicolas_upshifts" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1597535..1598275 /gene="rpsB" /locus_tag="BSU_16490" /old_locus_tag="BSU16490" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9090122, 10675340, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S2" /protein_id="NP_389531.1" /db_xref="EnsemblGenomes-Gn:BSU16490" /db_xref="EnsemblGenomes-Tr:CAB13522" /db_xref="GOA:P21464" /db_xref="InterPro:IPR001865" /db_xref="InterPro:IPR005706" /db_xref="InterPro:IPR018130" /db_xref="InterPro:IPR023591" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19004" /db_xref="UniProtKB/Swiss-Prot:P21464" /translation="MSVISMKQLLEAGVHFGHQTRRWNPKMKRYIFTERNGIYIIDLQ KTVKKVEEAYNFTKNLAAEGGKILFVGTKKQAQDSVKEEAQRSGMYYVNQRWLGGTLT NFETIQKRIKRLKDIEKMQENGTFDVLPKKEVVQLKKELERLEKFLGGIKDMKDLPDA LFIIDPRKERIAVAEARKLNIPIIGIVDTNCDPDEIDVVIPANDDAIRAVKLLTSKMA DAILEAKQGEEEAEVAEETAPETETTTA*" /label="rpsB CDS" gene 1597535..1598275 /gene="rpsB" /locus_tag="BSU_16490" /old_locus_tag="BSU16490" /label="rpsB gene" downshifts 1598257 /Source="Nicolas_upshifts" /id="D896" /incds=0 /nref=4 /ntot=61 /MaxReadThrough="9.04923" /MaxDrop="4.1312" /score="7.42766835" /energy="-14.3" /TU="U1324,U1328" /idTUdmin="U1323" /TUdmin=869 /isTUend="FALSE" /label="downshifts" S_feature 1598302..1598376 /Source="Nicolas_S_feature" /locus_tag="new_1718700_1718774" /HighExp="LPh, dia0, G150, G180, LBGexp, Lbexp, HPh, Oxctl, dia15, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S587" CDS 1598377..1599258 /gene="tsf" /locus_tag="BSU_16500" /old_locus_tag="BSU16500" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6396082, 9244380, 9973356, 27624934; Product type f: factor" /codon_start=1 /transl_table=11 /product="elongation factor Ts" /protein_id="NP_389532.1" /db_xref="EnsemblGenomes-Gn:BSU16500" /db_xref="EnsemblGenomes-Tr:CAB13523" /db_xref="GOA:P80700" /db_xref="InterPro:IPR001816" /db_xref="InterPro:IPR009060" /db_xref="InterPro:IPR014039" /db_xref="InterPro:IPR018101" /db_xref="InterPro:IPR036402" /db_xref="SubtiList:BG19025" /db_xref="UniProtKB/Swiss-Prot:P80700" /translation="MAITAQQVKELREKTGAGMMDCKKALTETDGDMDKAIDLLREKG IAKAAKKADRIAAEGSTLIKTDGNKGVILEVNSETDFVAKNEGFKELLNTLADHLLAN TPADVEEAMGQKMENGSTVEEYITSAVAKIGEKITLRRFTVLTKDDSSAFGAYLHMGG RIGVLTVLNGTTDEETAKDIAMHVAAVNPRYISRDQVSEEETNHERQILTQQALQEGK PENIVAKMVEGRLNKFFEEICLLDQAFVKNPDEKVKQVIAAKNATVQTFVRYEVGEGI EKRQENFAEEVMNQVKK*" /label="tsf CDS" gene 1598377..1599258 /gene="tsf" /locus_tag="BSU_16500" /old_locus_tag="BSU16500" /label="tsf gene" S_feature 1599259..1599403 /Source="Nicolas_S_feature" /locus_tag="new_1719657_1719801" /HighExp="LBGexp, G150, LBGtran, G135, G180, LPh, Oxctl, dia0, Lbexp, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S588" CDS 1599404..1600126 /gene="pyrH" /locus_tag="BSU_16510" /old_locus_tag="BSU16510" /EC_number="2.7.4.22" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9862121, 12682299, 12869195, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9862121, 12682299, 12869195, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uridylate kinase" /protein_id="NP_389533.2" /db_xref="EnsemblGenomes-Gn:BSU16510" /db_xref="EnsemblGenomes-Tr:CAB13524" /db_xref="GOA:O31749" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR011817" /db_xref="InterPro:IPR015963" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG12675" /db_xref="UniProtKB/Swiss-Prot:O31749" /translation="MEKPKYKRIVLKLSGEALAGEQGNGINPTVIQSIAKQVKEIAEL EVEVAVVVGGGNLWRGKTGSDLGMDRATADYMGMLATVMNSLALQDSLETLGIQSRVQ TSIEMRQVAEPYIRRKAIRHLEKKRVVIFAAGTGNPYFSTDTTAALRAAEIEADVILM AKNNVDGVYNADPRKDESAVKYESLSYLDVLKDGLEVMDSTASSLCMDNDIPLIVFSI MEEGNIKRAVIGESIGTIVRGK*" /label="pyrH CDS" gene 1599404..1600126 /gene="pyrH" /locus_tag="BSU_16510" /old_locus_tag="BSU16510" /label="pyrH gene" CDS 1600128..1600685 /gene="frr" /locus_tag="BSU_16520" /old_locus_tag="BSU16520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9862121, 12480895, 12682299, 14586115; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome recycling factor" /protein_id="NP_389534.1" /db_xref="EnsemblGenomes-Gn:BSU16520" /db_xref="EnsemblGenomes-Tr:CAB13525" /db_xref="GOA:P81101" /db_xref="InterPro:IPR002661" /db_xref="InterPro:IPR023584" /db_xref="InterPro:IPR036191" /db_xref="SubtiList:BG12587" /db_xref="UniProtKB/Swiss-Prot:P81101" /translation="MSKEVLTQTKEKMEKAIAAYQRELATVRAGRANPSLLDKVTVEY YGAQTPLNQLSSINVPEARMLVITPYDKTAIGDIEKAILKADLGLTPTSDGNMIRIAI PALTEERRKELVKVVKKYAEEAKVAVRNVRRDANDDLKKLEKNGDITEDELRASTEDV QKLTDEYVSKIDSVTKDKEKEIMEV*" /label="frr CDS" gene 1600128..1600685 /gene="frr" /locus_tag="BSU_16520" /old_locus_tag="BSU16520" /label="frr gene" downshifts complement(1600632) /Source="Nicolas_upshifts" /id="D897" /incds=0 /nref=1 /ntot=70 /MaxReadThrough="3.38183" /MaxDrop="3.17183" /score="-5.69560888" /energy="-4.8" /TU="NA" /idTUdmin="U1326" /TUdmin="-10739" /isTUend="FALSE" /label="downshifts" promotor_-35 1600674..1600677 /Source="Nicolas_upshift_promotors" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1600692..1600711 /Source="Nicolas_upshift_promotors" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1600710..1600815 /Source="Nicolas_S_feature" /locus_tag="new_1721108_1721213" /HighExp="G180, G135, T3.30H, Oxctl, G150, Cold, Paraq, C30, T3.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S589" upshifts 1600710 /Source="Nicolas_upshifts" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1600816..1601598 /gene="uppS" /locus_tag="BSU_16530" /old_locus_tag="BSU16530" /EC_number="2.5.1.31" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15788389, 16014871, 22904278, 23840410, 27578312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15788389, 16014871, 22904278, 23840410, 27578312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl pyrophosphate synthase" /protein_id="NP_389535.1" /db_xref="EnsemblGenomes-Gn:BSU16530" /db_xref="EnsemblGenomes-Tr:CAB13526" /db_xref="GOA:O31751" /db_xref="InterPro:IPR001441" /db_xref="InterPro:IPR018520" /db_xref="InterPro:IPR036424" /db_xref="SubtiList:BG13408" /db_xref="UniProtKB/Swiss-Prot:O31751" /translation="MLNILKNWKNQQTAASNLERYTKEDILKGEIPEHIAIIMDGNGR WAKKRSLPRIAGHHEGMKVVKRTTKLANELGVKVLTLYAFSTENWKRPKMEVDFLMKL PEEFLNTYLPELVEENVQVRIIGDETALPAHTLRAIEKAVQDTAQNDGMILNFALNYG GRTEIVSAAKSLAEKVKEGSLNIEDIDESLFSTYLMTESLQDPELLIRTSGEIRLSNF MLWQVAYSEFVFTDVLWPDFKEDHFLQALGEFQQRGRRFGGI*" /label="uppS CDS" gene 1600816..1601598 /gene="uppS" /locus_tag="BSU_16530" /old_locus_tag="BSU16530" /label="uppS gene" CDS 1601602..1602411 /gene="cdsA" /locus_tag="BSU_16540" /old_locus_tag="BSU16540" /EC_number="2.7.7.41" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 175832, 12682299, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidate cytidylyltransferase (CDP-diglyceride synthase)" /protein_id="NP_389536.1" /db_xref="EnsemblGenomes-Gn:BSU16540" /db_xref="EnsemblGenomes-Tr:CAB13527" /db_xref="GOA:O31752" /db_xref="InterPro:IPR000374" /db_xref="SubtiList:BG12575" /db_xref="UniProtKB/Swiss-Prot:O31752" /translation="MVDMKQRILTGVLAAIVFLFLVIVGKLPFTILIYAMGSVALFEL LRMKKLKLVSLPGLIGLLLLWMFLLPSQYSFFEADGISKMEIALFAVLLLLTYTVLVK NTFTFDEVGFITLAAIYIGMCFHYFIEIRNLDQYGLTYIFYACVVIWSTDSGAYFVGK SLGKRKLWPEISPNKTVEGFAGGIVIALVLATIFQLVAQLPIPYIYLLLITLFLSVFG QLGDLVESALKRHYDVKDSGNILPGHGGILDRFDSFLFVMPFLYFLLALFS*" /label="cdsA" gene 1601602..1602411 /gene="cdsA" /locus_tag="BSU_16540" /old_locus_tag="BSU16540" /label="cdsA gene" promotor_-35 1602392..1602399 /Source="Nicolas_upshift_promotors" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1602414..1602433 /Source="Nicolas_upshift_promotors" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1602415 /Source="Nicolas_upshifts" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1602473..1603624 /gene="dxr" /locus_tag="BSU_16550" /old_locus_tag="BSU16550" /EC_number="1.1.1.267" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15567415, 17458547, 21296950, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15567415, 17458547, 21296950, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-deoxy-D-xylulose-5-phosphate reductoisomerase" /protein_id="NP_389537.2" /db_xref="EnsemblGenomes-Gn:BSU16550" /db_xref="EnsemblGenomes-Tr:CAB13528" /db_xref="GOA:O31753" /db_xref="InterPro:IPR003821" /db_xref="InterPro:IPR013512" /db_xref="InterPro:IPR013644" /db_xref="InterPro:IPR026877" /db_xref="InterPro:IPR036169" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13409" /db_xref="UniProtKB/Swiss-Prot:O31753" /translation="MKNICLLGATGSIGEQTLDVLRAHQDQFQLVSMSFGRNIDKAVP MIEVFQPKFVSVGDLDTYHKLKQMSFSFECQIGLGEEGLIEAAVMEEVDIVVNALLGS VGLIPTLKAIEQKKTIALANKETLVTAGHIVKEHAKKYDVPLLPVDSEHSAIFQALQG EQAKNIERLIITASGGSFRDKTREELESVTVEDALKHPNWSMGAKITIDSATMMNKGL EVIEAHWLFDIPYEQIDVVLHKESIIHSMVEFHDKSVIAQLGTPDMRVPIQYALTYPD RLPLPDAKRLELWEIGSLHFEKADFDRFRCLQFAFESGKIGGTMPTVLNAANEVAVAA FLAGKIPFLAIEDCIEKALTRHQLLKKPSLADIQEVDKDTRGYVNSILT*" /label="dxr CDS" gene 1602473..1603624 /gene="dxr" /locus_tag="BSU_16550" /old_locus_tag="BSU16550" /label="dxr gene" CDS 1603631..1604899 /gene="rasP" /locus_tag="BSU_16560" /old_locus_tag="BSU16560" /EC_number="3.4.24.-" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15130127, 15496982, 15520285, 16014871, 16899079, 18599827, 19889088, 20644139, 21810987, 26735940, 28376795, 28674070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130127, 15496982, 15520285, 16014871, 16899079, 18599827, 19889088, 20644139, 21810987, 26735940, 28376795, 28674070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inner membrane zinc metalloprotease required forthe extracytoplasmic stress response mediated by sigma(W)" /protein_id="NP_389538.1" /db_xref="EnsemblGenomes-Gn:BSU16560" /db_xref="EnsemblGenomes-Tr:CAB13529" /db_xref="GOA:O31754" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR004387" /db_xref="InterPro:IPR008915" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG13410" /db_xref="UniProtKB/Swiss-Prot:O31754" /translation="MFVNTVIAFIIIFGTLVFFHELGHLLLAQRAGILCREFAIGFGP KIFSFKKNETVYTIRLLPVGGFVRMAGEDPEMIEVKPGYTVGLLFNKEDQVEKVIINQ KEKYPDALVIEVETADLEHDMKITGYEQGKEDELSSFTVSETSFFIVDGEEVQIAPYN RQFGSKPVWQRIKAIAAGPIMNFILAYVILVMLGLIQGVPSNEPMLGQLTDNGRAAEA GLKEGDYIQSINGEKMRSWTDIVSAVKENPEKEMDVAVKRDNKTLHISVTPEAVKDEN KKTIGRFGSYAPTEKGVLSAVAYGATSTVDVTKAILTNLSKLVTGQFKLDMLSGPVGI YDMTDQVAKTGIVNLFQFAAFLSINLGIVNLLPIPALDGGRLLFLFIEAIRGKPINRE KEAFVVFIGVAFLMLLMLVVTWNDIQRLFL*" /label="rasP CDS" gene 1603631..1604899 /gene="rasP" /locus_tag="BSU_16560" /old_locus_tag="BSU16560" /label="rasP gene" CDS 1604932..1606626 /gene="proS" /locus_tag="BSU_16570" /old_locus_tag="BSU16570" /EC_number="6.1.1.15" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16864571, 26886480; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prolyl-tRNA synthetase" /protein_id="NP_389539.1" /db_xref="EnsemblGenomes-Gn:BSU16570" /db_xref="EnsemblGenomes-Tr:CAB13530" /db_xref="GOA:O31755" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002316" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR004500" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR023717" /db_xref="InterPro:IPR033730" /db_xref="InterPro:IPR036621" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG12659" /db_xref="UniProtKB/Swiss-Prot:O31755" /translation="MRQSLTLIPTLREVPADAEAKSHQLLLRAGFIRQNTSGVYSYMP LAYKVIQNIQQIVREEMEKIDAVEMLMPALQQAETWQESGRWYTYGPELMRLKDRHGR EFALGATHEEVITSLVRDEVKSYKRLPLTLYQIQSKFRDEKRPRFGLLRGREFIMKDA YSFHASAESLDETYQKMYEAYSNIFARCGINVRPVIADSGAMGGKDTHEFMALSAIGE DTIAYSDESQYAANIEMAEVLHQEVPSDEEPKALEKVHTPNVKTIEELTAFLQVSAEA CIKSVLFKADDRFVLVLVRGDHEVNDIKVKNLLHAEVVELATHEEVIQQLGTEPGFVG PVGIHQDVEVYADQAVKAMVNAVAGANEGDHHYKNVNVNRDAQIKEFADLRFIKEGDP SPDGKGTIRFAEGIEVGQVFKLGTRYSEAMNATYLDENGRAQPMLMGCYGIGVSRTLS AIAEQHHDEKGLIWPKSVAPYDLHILALNMKNDGQRELAEKLYADLKAEGYEVLYDDR AERAGVKFADSDLIGLPIRITVGKRADEGIVEVKIRQTGESTEISVDELSAFISKQ*" /label="proS CDS" gene 1604932..1606626 /gene="proS" /locus_tag="BSU_16570" /old_locus_tag="BSU16570" /label="proS gene" S_feature 1606627..1606734 /Source="Nicolas_S_feature" /locus_tag="new_1727025_1727132" /HighExp="G135, G180, G150, C30, Oxctl, H2O2, Paraq, LPh, LBGexp, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S590" CDS 1606735..1611048 /gene="polC" /locus_tag="BSU_16580" /old_locus_tag="BSU16580" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11721055, 12081953, 12217498, 20122408, 21740522, 24106089, 28575448" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11721055, 12081953, 12217498, 20122408, 21740522, 24106089, 28575448; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (alpha subunit)" /protein_id="NP_389540.1" /db_xref="EnsemblGenomes-Gn:BSU16580" /db_xref="EnsemblGenomes-Tr:CAB13531" /db_xref="GOA:P13267" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR006054" /db_xref="InterPro:IPR006308" /db_xref="InterPro:IPR011708" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR024754" /db_xref="InterPro:IPR028112" /db_xref="InterPro:IPR029460" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG10263" /db_xref="UniProtKB/Swiss-Prot:P13267" /translation="MEQLSVNRRQFQILLQQINMTDDTFMTYFEHGEIKKLTIHKASK SWHFHFQFKSLLPFQIYDTLTTRLTQSFAHIAKVTSSIEVQDAEVSESIVQDYWSRCI EELQGISPPIISLLNQQKPKLKGNKLIVKTKTDTEAAALKNKYSSMIQAEYRQFGFPD LQLDAEIFVSEQEVQKFREQKLAEDQERAMQALIEMEKKDKESDEDQAPSGPLVIGYQ IKDNEEIRTLDSIMDEERRITVQGYVFDVETRELKSGRTLCIFKITDYTNSILIKMFA REKEDAALMKSLKKGMWVKARGSIQNDTFVRDLVMIANDVNEIKAKTREDSAPEGEKR VELHLHSPMSQMDAVTGIGKLVEQAKKWGHEAIALTDHAVVQSFPDAYSAAKKHGIKM IYGMEANLVDDGVPIAYNAAHRLLEEETYVVFDVETTGLSAVYDTIIELAAVKVKGGE IIDKFEAFANPHRPLSATIIELTGITDDMLQDAPDVVDVIRDFREWIGDDILVAHNAS FDMGFLNVAYKKLLEVEKAKNPVIDTLELGRFLYPEFKNHRLNTLCKKFDIELTQHHR AIYDTEATAYLLLKMLKDAAEKGIQYHDELNENMGQSNAYQRSRPYHATLLAVNSTGL KNLFKLVSLSHIHYFYRVPRIPRSQLEKYREGLLIGSACDRGEVFEGMMQKSPEEVED IASFYDYLEVQPPEVYRHLLELELVRDEKALKEIIANITKLGEKLNKPVVATGNVHYL NDEDKIYRKILISSQGGANPLNRHELPKVHFRTTDEMLEAFSFLGEEKAKEIVVTNTQ KVASLVDDIKPIKDDLYTPKIEGADEEIREMSYQRARSIYGEELPEIVEARIEKELKS IIGHGFAVIYLISHKLVKRSLDDGYLVGSRGSVGSSLVATLTEITEVNPLPPHYVCPE CQHSEFFNDGSVGSGFDLPDKTCPHCGTPLKKDGHDIPFETFLGFKGDKVPDIDLNFS GEYQPQAHNYTKVLFGEDNVYRAGTIGTVAEKTAYGYVKGYAGDNNLHMRGAEIDRLV QGCTGVKRTTGQHPGGIIVVPDYMDIYDFSPIQFPADATGSEWKTTHFDFHSIHDNLL KLDILGHDDPTVIRMLQDLSGIDPKTIPTDDPEVMKIFQGTESLGVTEEQIGCKTGTL GIPEFGTRFVRQMLEDTKPTTFSELVQISGLSHGTDVWLGNAQELIHNNICELSEVIG CRDDIMVYLIYQGLEPSLAFKIMEFVRKGKGLTPEWEEEMKNNNVPDWYIDSCKKIKY MFPKAHAAAYVLMAVRIAYFKVHHALLYYAAYFTVRADDFDIDTMIKGSTAIRAVMED INAKGLDASPKEKNLLTVLELALEMCERGYSFQKVDLYRSSATEFIIDGNSLIPPFNS IPGLGTNAALNIVKAREEGEFLSKEDLQKRGKVSKTILEYLDRHGCLESLPDQNQLSL F*" /label="polC CDS" gene 1606735..1611048 /gene="polC" /locus_tag="BSU_16580" /old_locus_tag="BSU16580" /label="polC gene" S_feature 1611049..1611113 /Source="Nicolas_S_feature" /locus_tag="new_1731447_1731511" /HighExp="C30, G180, G135, Oxctl, G150, H2O2, Paraq, Cold, LBGstat, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S591" misc_RNA 1611059..1611276 /gene="surG" /locus_tag="BSU_misc_RNA_71" /product="small RNAs controlled by sporulation" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" /label="surG RNA" gene 1611059..1611276 /gene="surG" /locus_tag="BSU_misc_RNA_71" /label="surG gene" promotor_-35 1611085..1611091 /Source="Nicolas_upshift_promotors" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="promotor_-35" promotor_-10 1611106..1611117 /Source="Nicolas_upshift_promotors" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="promotor_-10" S_feature 1611115..1611182 /Source="Nicolas_S_feature" /locus_tag="new_1731513_1731580" /HighExp="S7, S5, S4, S8, S6, S3, G180, C30, T5.0H, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S592" upshifts 1611115 /Source="Nicolas_upshifts" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="upshifts" promotor_-35 1611165..1611171 /Source="Nicolas_upshift_promotors" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="promotor_-35" S_feature 1611184..1611377 /Source="Nicolas_S_feature" /locus_tag="new_1731582_1731775" /HighExp="LoTm, Cold, HPh, G180, Paraq, Oxctl, T-5.40H, BMM, G150, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S593" upshifts 1611184 /Source="Nicolas_upshifts" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="upshifts" promotor_-10 1611185..1611204 /Source="Nicolas_upshift_promotors" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="promotor_-10" CDS 1611378..1611848 /gene="rimP" /locus_tag="BSU_16590" /old_locus_tag="BSU16590" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15257761, 16014871, 19150615, 20188109, 21529161; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome maturation factor" /protein_id="NP_389541.1" /db_xref="EnsemblGenomes-Gn:BSU16590" /db_xref="EnsemblGenomes-Tr:CAB13532" /db_xref="GOA:P32726" /db_xref="InterPro:IPR003728" /db_xref="InterPro:IPR028989" /db_xref="InterPro:IPR028998" /db_xref="InterPro:IPR035956" /db_xref="InterPro:IPR036847" /db_xref="SubtiList:BG10264" /db_xref="UniProtKB/Swiss-Prot:P32726" /translation="MSKKVTDTVQEMAQPIVDSLQLELVDIEFVKEGQSWFLRVFIDS DDGVDIEECAKVSEALSEKLDEADPISQNYFLEVSSPGAERPLKKKADFEKSLGKNVY IKTYEPIDGVKVFEGELAEFDGQTVTVEITIKTRKKRINIPYEKIANARLAVTF*" /label="rimP CDS" gene 1611378..1611848 /gene="rimP" /locus_tag="BSU_16590" /old_locus_tag="BSU16590" /label="rimP gene" downshifts complement(1611699) /Source="Nicolas_upshifts" /id="D898" /incds=1 /nref=3 /ntot=136 /MaxReadThrough="2.08299" /MaxDrop="3.17419" /score="-8.18111474" /energy="-9.2" /TU="NA" /idTUdmin="U1333" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1611883..1612998 /gene="nusA" /locus_tag="BSU_16600" /old_locus_tag="BSU16600" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15978071, 16707701, 16946247, 27571753, 28507243" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15978071, 16707701, 16946247, 27571753, 28507243; Product type f : factor" /codon_start=1 /transl_table=11 /product="transcription translation coupling factor involved in Rho-dependent transcription termination" /protein_id="NP_389542.1" /db_xref="EnsemblGenomes-Gn:BSU16600" /db_xref="EnsemblGenomes-Tr:CAB13533" /db_xref="GOA:P32727" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR010213" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013735" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR025249" /db_xref="InterPro:IPR030842" /db_xref="InterPro:IPR036555" /db_xref="PDB:2MT4" /db_xref="SubtiList:BG10265" /db_xref="UniProtKB/Swiss-Prot:P32727" /translation="MSSELLDALTILEKEKGISKEIIIEAIEAALISAYKRNFNQAQN VRVDLNRETGSIRVFARKDVVDEVYDQRLEISIEEAQGIHPEYMVGDVVEIEVTPKDF GRIAAQTAKQVVTQRVREAERGVIYSEFIDREEDIMTGIVQRLDNKFIYVSLGKIEAL LPVNEQMPNESYKPHDRIKVYITKVEKTTKGPQIYVSRTHPGLLKRLFEIEVPEIYDG TVELKSVAREAGDRSKISVRTDDPDVDPVGSCVGPKGQRVQAIVNELKGEKIDIVNWS SDPVEFVANALSPSKVLDVIVNEEEKATTVIVPDYQLSLAIGKRGQNARLAAKLTGWK IDIKSETDARELGIYPRELEEDDEPLFTEPETAESDE*" /label="nusA CDS" gene 1611883..1612998 /gene="nusA" /locus_tag="BSU_16600" /old_locus_tag="BSU16600" /label="nusA gene" promotor_no_box complement(1611945..1612045) /Source="Nicolas_upshift_promotors" /id="U1333" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.775224775224775" /psig="0.171828171828172" /xcortree=61 /SigmaFactorBS="agccagtttcacggtttagatccacccgtacattttgcgctt gattaaaattccgcttataagcagaaattaacgcagcttcgattgcttcgatgataat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1611985) /Source="Nicolas_upshifts" /id="U1333" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.775224775224775" /psig="0.171828171828172" /xcortree=61 /SigmaFactorBS="agccagtttcacggtttagatccacccgtacattttgcgctt gattaaaattccgcttataagcagaaattaacgcagcttcgattgcttcgatgataat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1613012..1613287 /gene="rulR" /locus_tag="BSU_16610" /old_locus_tag="BSU16610" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11679764, 12682299, 26771646, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="molecular ruler co-factor for RNA; new fold" /protein_id="NP_389543.1" /db_xref="EnsemblGenomes-Gn:BSU16610" /db_xref="EnsemblGenomes-Tr:CAB13534" /db_xref="InterPro:IPR007393" /db_xref="InterPro:IPR035931" /db_xref="SubtiList:BG10266" /db_xref="UniProtKB/Swiss-Prot:P32728" /translation="MNKHKKIPLRKCVVTGEMKPKKELIRVVRSKEGEISVDPTGKKN GRGAYLTLDKECILAAKKKNTLQNQFQSQIDDQIFDELLELAEKVKK*" /label="rulR CDS" gene 1613012..1613287 /gene="rulR" /locus_tag="BSU_16610" /old_locus_tag="BSU16610" /label="rulR gene" CDS 1613289..1613591 /gene="rulQ" /locus_tag="BSU_16620" /old_locus_tag="BSU16620" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15130481, 15361074, 22355167, 26522935, 26771646" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130481, 15361074, 22355167, 26522935, 26771646; Product type f: factor" /codon_start=1 /transl_table=11 /product="K-turn RNA binding protein" /protein_id="NP_389544.1" /db_xref="EnsemblGenomes-Gn:BSU16620" /db_xref="EnsemblGenomes-Tr:CAB13535" /db_xref="GOA:P32729" /db_xref="InterPro:IPR004037" /db_xref="InterPro:IPR004038" /db_xref="InterPro:IPR029064" /db_xref="PDB:3V7Q" /db_xref="SubtiList:BG10267" /db_xref="UniProtKB/Swiss-Prot:P32729" /translation="MSGMEWFPLLGLANRARKVVSGEDLVIKEIRNARAKLVLLTEDA SSNTAKKVTDKCNYYKVPYKKVESRAVLGRSIGKEARVVVAVTDQGFANKLISLLD*" /label="rulQ CDS" gene 1613289..1613591 /gene="rulQ" /locus_tag="BSU_16620" /old_locus_tag="BSU16620" /label="rulQ gene" CDS 1613611..1615761 /gene="infB" /locus_tag="BSU_16630" /old_locus_tag="BSU16630" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1426242, 9588797, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1426242, 9588797, 12682299, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-2" /protein_id="NP_389545.1" /db_xref="EnsemblGenomes-Gn:BSU16630" /db_xref="EnsemblGenomes-Tr:CAB13536" /db_xref="GOA:P17889" /db_xref="InterPro:IPR000178" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006847" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR015760" /db_xref="InterPro:IPR023115" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036925" /db_xref="SubtiList:BG10268" /db_xref="UniProtKB/Swiss-Prot:P17889" /translation="MAKMRVYEYAKALNVSSKEILTALKNMDLEVNNHMAMLEEKAIK KLDAKYKKGGAAAKSQKPAETNKNKQPQGVNQQSAGNQPNKIRDGKKNDVQNNQFNKN KKNNNNKKNKRNNNNNKNQHQQKPVKPKKELPEKITFSGTLTVGALAEELGKEPSELI KKLMLLGVMATINQELDKDTIELIASEYGVETEEVIVLEETELEKYEEPDNEEDLEIR PPVVTIMGHVDHGKTTLLDSIRKTKVVEGEAGGITQHIGAYQIEENGKKITFLDTPGH AAFTTMRARGAEVTDITILVVAADDGVMPQTVEAINHAKAAEVPIIVAVNKIDKESAN PDRVMQELTEYGLVPEAWGGETIFVPLSALTGKGIDELVEMILLVSEVEELKANPNRQ AKGTVIEAELDKGRGSVATLLVQTGTLHVGDPIVVGNTFGRVRAMVNDIGRRVKTAGP STPVEITGLNDVPQAGDQFLVFKDEKTARSVGEARASKQLEEQRSDKAKLSLDDLFEQ IKQGDVKDINLIVKADVQGSAEALTAALQKIEVEGVKVKIIHTGVGAITESDIILASA SNAIVIGFNVRPDGNAKSTAEAENVDIRLHRIIYKVIDEIEAAMKGMLDPEYEEKVIG QVEVRQTFKVSKIGTIAGGYVTEGTITRDSGLRLIRDGVVIFEGEVDVLKRFKDDVKE VSQGYECGITIKKYNDIREGDILEAFVMQEIERT*" /label="infB CDS" gene 1613611..1615761 /gene="infB" /locus_tag="BSU_16630" /old_locus_tag="BSU16630" /label="infB gene" promotor_-35 1615656..1615662 /Source="Nicolas_upshift_promotors" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1615671 /Source="Nicolas_upshifts" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1615677..1615695 /Source="Nicolas_upshift_promotors" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1615758..1616036 /gene="ylxP" /locus_tag="BSU_16640" /old_locus_tag="BSU16640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="fragment of conserved protein" /db_xref="EnsemblGenomes-Gn:BSU16640" /db_xref="EnsemblGenomes-Tr:CAB13537" /db_xref="InterPro:IPR007546" /db_xref="InterPro:IPR036746" /db_xref="PSEUDO:CAB13537.1" /db_xref="SubtiList:BG10269" /db_xref="UniProtKB/Swiss-Prot:P32730" /translation="MIGFAECECIIYDAGSLKEKRAVLKRILTRVQNKFNVSISEIGY QDTWQRTSFGIAAVSSSRVQTEKELQRVLAFIDSFPEIERTITRTEWF*" /label="ylxP CDS" gene 1615758..1616036 /gene="ylxP" /locus_tag="BSU_16640" /old_locus_tag="BSU16640" /pseudo /label="ylxP gene" CDS 1616053..1616406 /gene="rbfA" /locus_tag="BSU_16650" /old_locus_tag="BSU16650" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12628255, 15185964, 17996707, 21102555, 21529161, 23293003, 23611982, 24671761, 25904134, 27382067; Product type f: factor" /codon_start=1 /transl_table=11 /product="pre-ribosomal (17S) RNA binding factor A" /protein_id="NP_389547.1" /db_xref="EnsemblGenomes-Gn:BSU16650" /db_xref="EnsemblGenomes-Tr:CAB13538" /db_xref="GOA:P32731" /db_xref="InterPro:IPR000238" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR020053" /db_xref="InterPro:IPR023799" /db_xref="SubtiList:BG10270" /db_xref="UniProtKB/Swiss-Prot:P32731" /translation="MSMRANRVGEQMKKELGDIISRKLKDPRIGFLTVTDVRVSGDLQ IAKVYISVLGDEKKREEALKGLAKAKGFIRSEIGSRIRLRKTPEIEFEFDESIDYGNR IETLIHELHSEKPSE*" /label="rbfA CDS" gene 1616053..1616406 /gene="rbfA" /locus_tag="BSU_16650" /old_locus_tag="BSU16650" /label="rbfA gene" downshifts 1616397 /Source="Nicolas_upshifts" /id="D899" /incds=0 /nref=9 /ntot=130 /MaxReadThrough="6.97196" /MaxDrop="5.80207" /score="-3.06560848" /energy="-13.8" /TU="U1331,U1332,U1334" /idTUdmin="U1331" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" CDS 1616488..1617417 /gene="truB" /locus_tag="BSU_16660" /old_locus_tag="BSU16660" /EC_number="5.4.99.25" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7489483, 15987897; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA pseudouridine 55 synthase" /protein_id="NP_389548.1" /db_xref="EnsemblGenomes-Gn:BSU16660" /db_xref="EnsemblGenomes-Tr:CAB13539" /db_xref="GOA:P32732" /db_xref="InterPro:IPR002501" /db_xref="InterPro:IPR014780" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR032819" /db_xref="SubtiList:BG10271" /db_xref="UniProtKB/Swiss-Prot:P32732" /translation="MVNGVLLLHKPVGMTSHDCVMKIRKLLKTKKVGHTGTLDPEVSG VLPICVGRATKIVEYLTEKSKTYDAEITLGFSTTTEDQTGETVETKPVNHDIDKADVE KVLNSLKGKQEQIPPMYSAVKVNGKKLYEYARAGIEVERPKRMITIEDIALTTEIKHH GETASFRFTVTCSKGTYVRTLAVMIGEKLGYPAHMSHLIRTASGDFSLDECFTFDELE AQAQSGTVEEHTVPIERALNHLPKWIISDTLAKKVENGALLETPEQFSEMTSGDRIAV FTESGTCLAIYFPHPAKKGLLKPAKVLMQKSEQ*" /label="truB CDS" gene 1616488..1617417 /gene="truB" /locus_tag="BSU_16660" /old_locus_tag="BSU16660" /label="truB gene" promotor_-35 1617202..1617209 /Source="Nicolas_upshift_promotors" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1617223..1617242 /Source="Nicolas_upshift_promotors" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1617232 /Source="Nicolas_upshifts" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="upshifts" CDS 1617436..1618386 /gene="ribC" /locus_tag="BSU_16670" /old_locus_tag="BSU16670" /EC_number="2.7.1.26" /EC_number="2.7.7.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9473052, 10206712, 12456892, 15668000, 18156273, 21866869" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9473052, 10206712, 12456892, 15668000, 18156273, 21866869; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="bifunctional riboflavin kinase FAD synthase" /protein_id="NP_389549.1" /db_xref="EnsemblGenomes-Gn:BSU16670" /db_xref="EnsemblGenomes-Tr:CAB13540" /db_xref="GOA:P54575" /db_xref="InterPro:IPR002606" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015864" /db_xref="InterPro:IPR015865" /db_xref="InterPro:IPR023465" /db_xref="InterPro:IPR023468" /db_xref="SubtiList:BG11495" /db_xref="UniProtKB/Swiss-Prot:P54575" /translation="MKTIHITHPHHLIKEEQAKSVMALGYFDGVHLGHQKVIGTAKQI AEEKGLTLAVMTFHPHPSHVLGRDKEPKDLITPLEDKINQIEQLGTEVLYVVKFNEVF ASLSPKQFIDQYIIGLNVQHAVAGFDFTYGKYGKGTMKTMPDDLDGKAGCTMVEKLTE QDKKISSSYIRTALQNGDVELANVLLGQPYFIKGIVIHGDKRGRTIGFPTANVGLNNS YIVPPTGVYAVKAEVNGEVYNGVCNIGYKPTFYEKRPEQPSIEVNLFDFNQEVYGAAI KIEWYKRIRSERKFNGIKELTEQIEKDKQEAIRYFSNLRK*" /label="ribC CDS" gene 1617436..1618386 /gene="ribC" /locus_tag="BSU_16670" /old_locus_tag="BSU16670" /label="ribC gene" promotor_-35 1618419..1618425 /Source="Nicolas_upshift_promotors" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1618426..1618542 /Source="Nicolas_S_feature" /locus_tag="new_1738824_1738940" /HighExp="SMM, GM 15, Salt, T-4.40H, GM 45, T-5.40H, GM 60, MG 45, LPhT, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S594" upshifts 1618426 /Source="Nicolas_upshifts" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1618440..1618459 /Source="Nicolas_upshift_promotors" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1618543..1618812 /gene="rpsO" /locus_tag="BSU_16680" /old_locus_tag="BSU16680" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15627386, 8825778, 20418391, 22720735, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15627386, 8825778, 20418391, 22720735, 23611891; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S15 (BS18)" /protein_id="NP_389550.1" /db_xref="EnsemblGenomes-Gn:BSU16680" /db_xref="EnsemblGenomes-Tr:CAB13541" /db_xref="GOA:P21473" /db_xref="InterPro:IPR000589" /db_xref="InterPro:IPR005290" /db_xref="InterPro:IPR009068" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19010" /db_xref="UniProtKB/Swiss-Prot:P21473" /translation="MAITQERKNQLINEFKTHESDTGSPEVQIAILTDSINNLNEHLR THKKDHHSRRGLLKMVGKRRNLLTYLRNKDVTRYRELINKLGLRR*" /label="rpsO CDS" gene 1618543..1618812 /gene="rpsO" /locus_tag="BSU_16680" /old_locus_tag="BSU16680" /label="rpsO gene" downshifts 1618795 /Source="Nicolas_upshifts" /id="D900" /incds=0 /nref=30 /ntot=154 /MaxReadThrough="8.65904" /MaxDrop="5.6648" /score="29.9198852" /energy="-10.2" /TU="U1332,U1334,U1335,U1336" /idTUdmin="U1331" /TUdmin=2090 /isTUend="FALSE" /label="downshifts" S_feature 1618840..1618925 /Source="Nicolas_S_feature" /locus_tag="new_1739238_1739323" /HighExp="Cold, LoTm, Oxctl, G180, H2O2, G150, dia15, Paraq, LPh, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S595" promotor_-35 1618906..1618909 /Source="Nicolas_upshift_promotors" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1618925..1618944 /Source="Nicolas_upshift_promotors" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1618927 /Source="Nicolas_upshifts" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="upshifts" CDS 1618985..1621102 /gene="pnpA" /locus_tag="BSU_16690" /old_locus_tag="BSU16690" /EC_number="2.7.7.8" /EC_number="3.1.13.1" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8636041, 8825779, 9179491, 10572137, 15805522, 19215769, 19433509, 20659169, 21859751, 22568516, 25099370, 27708634" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8636041, 8825779, 9179491, 10572137, 15805522, 19215769, 19433509, 20659169, 21859751, 22568516, 25099370, 27708634; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polynucleotide phosphorylase (PNPase)" /protein_id="NP_389551.1" /db_xref="EnsemblGenomes-Gn:BSU16690" /db_xref="EnsemblGenomes-Tr:CAB13542" /db_xref="GOA:P50849" /db_xref="InterPro:IPR001247" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR004088" /db_xref="InterPro:IPR012162" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR015847" /db_xref="InterPro:IPR015848" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR027408" /db_xref="InterPro:IPR036345" /db_xref="InterPro:IPR036456" /db_xref="InterPro:IPR036612" /db_xref="SubtiList:BG11491" /db_xref="UniProtKB/Swiss-Prot:P50849" /translation="MGQEKHVFTIDWAGRTLTVETGQLAKQANGAVMIRYGDTAVLST ATASKEPKPLDFFPLTVNYEERLYAVGKIPGGFIKREGRPSEKAVLASRLIDRPIRPL FADGFRNEVQVISIVMSVDQNCSSEMAAMFGSSLALSVSDIPFEGPIAGVTVGRIDDQ FIINPTVDQLEKSDINLVVAGTKDAINMVEAGADEVPEEIMLEAIMFGHEEIKRLIAF QEEIVAAVGKEKSEIKLFEIDEELNEKVKALAEEDLLKAIQVHEKHAREDAINEVKNA VVAKFEDEEHDEDTIKQVKQILSKLVKNEVRRLITEEKVRPDGRGVDQIRPLSSEVGL LPRTHGSGLFTRGQTQALSVCTLGALGDVQILDGLGVEESKRFMHHYNFPQFSVGETG PMRGPGRREIGHGALGERALEPVIPSEKDFPYTVRLVSEVLESNGSTSQASICASTLA MMDAGVPIKAPVAGIAMGLVKSGEHYTVLTDIQGMEDALGDMDFKVAGTEKGVTALQM DIKIEGLSREILEEALQQAKKGRMEILNSMLATLSESRKELSRYAPKILTMTINPDKI RDVIGPSGKQINKIIEETGVKIDIEQDGTIFISSTDESGNQKAKKIIEDLVREVEVGQ LYLGKVKRIEKFGAFVEIFSGKDGLVHISELALERVGKVEDVVKIGDEILVKVTEIDK QGRVNLSRKAVLREEKEKEEQQS*" /label="pnpA CDS" gene 1618985..1621102 /gene="pnpA" /locus_tag="BSU_16690" /old_locus_tag="BSU16690" /label="pnpA gene" downshifts 1620885 /Source="Nicolas_upshifts" /id="D901" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="8.05841" /MaxDrop="3.82025" /score="-9.33432702" /energy="-7.8" /TU="U1332,U1334,U1335,U1336,U1337" /idTUdmin="U1337" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" downshifts 1621086 /Source="Nicolas_upshifts" /id="D902" /incds=0 /nref=192 /ntot=270 /MaxReadThrough="5.61214" /MaxDrop="6.82185" /score="-9.33432702" /energy="-7.8" /TU="U1332,U1334,U1335,U1336" /idTUdmin="U1337" /TUdmin=3 /isTUend="TRUE" /label="downshifts" S_feature 1621131..1621219 /Source="Nicolas_S_feature" /locus_tag="new_1741529_1741617" /HighExp="G135, G180, G150, H2O2, Oxctl, LBGexp, Paraq, LoTm, LPh, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S596" CDS 1621220..1622179 /gene="ylxY" /locus_tag="BSU_16700" /old_locus_tag="BSU16700" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14679227; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar deacetylase" /protein_id="NP_389552.1" /db_xref="EnsemblGenomes-Gn:BSU16700" /db_xref="EnsemblGenomes-Tr:CAB13543" /db_xref="GOA:P50850" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR010916" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014228" /db_xref="SubtiList:BG11492" /db_xref="UniProtKB/Swiss-Prot:P50850" /translation="MYKKFVPFAVFLFLFFVSFEMMENPHALDYIGAMKKDTVTVTAS KDPLYEELLQKAPEYEVKPQNARIDKVWKSIPGYNGLKVNIEQSYKKMKQHGKFREKD LVYSQVKPSVHLESLQPEPIYKGNPDKPMVAFLINVAWGNEYLEKMLPILQKHQVKAT FFLEGNWVRNNVQLAKKIAKDGHEIGNHSYNHPDMSKLTTGRISEQLDKTNEQIEQTI GVKPKWFAPPSGSFRKAVIDIAAEKQMGTVMWTVDTIDWQKPAPSVLQTRVLSKIHNG AMILMHPTDPTAESLEALITQIKDKGYALGTVTELMDETRLLK*" /label="ylxY CDS" gene 1621220..1622179 /gene="ylxY" /locus_tag="BSU_16700" /old_locus_tag="BSU16700" /label="ylxY gene" promotor_-10 complement(1621288..1621296) /Source="Nicolas_upshift_promotors" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1621291) /Source="Nicolas_upshifts" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1621310..1621317) /Source="Nicolas_upshift_promotors" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1621783..1621788 /Source="Nicolas_upshift_promotors" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1621804..1621822 /Source="Nicolas_upshift_promotors" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1621809 /Source="Nicolas_upshifts" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="upshifts" CDS 1622219..1623448 /gene="mlpA" /locus_tag="BSU_16710" /old_locus_tag="BSU16710" /EC_number="3.4.24.-" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10666719, 10974125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10666719, 10974125; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="specific processing protease" /protein_id="NP_389553.2" /db_xref="EnsemblGenomes-Gn:BSU16710" /db_xref="EnsemblGenomes-Tr:CAB13544" /db_xref="GOA:Q04805" /db_xref="InterPro:IPR001431" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR011765" /db_xref="SubtiList:BG10779" /db_xref="UniProtKB/Swiss-Prot:Q04805" /translation="MIKRYTCQNGVRIVLENNPTVRSVAIGVWIGTGSRHETPEINGI SHFLEHMFFKGTSTKSAREIAESFDRIGGQVNAFTSKEYTCYYAKVLDEHANYALDVL ADMFFHSTFDENELKKEKNVVYEEIKMYEDAPDDIVHDLLSKATYGNHSLGYPILGTE ETLASFNGDSLRQYMHDYYTPDRVVISVAGNISDSFIKDVEKWFGSYEAKGKATGLEK PEFHTEKLTRKKETEQAHLCLGFKGLEVGHERIYDLIVLNNVLGGSMSSRLFQDVRED KGLAYSVYSYHSSYEDSGMLTIYGGTGANQLQQLSETIQETLATLKRDGITSKELENS KEQMKGSLMLSLESTNSKMSRNGKNELLLGKHKTLDEIINELNAVNLERVNGLARQLF TEDYALALISPSGNMPS*" /label="mlpA CDS" gene 1622219..1623448 /gene="mlpA" /locus_tag="BSU_16710" /old_locus_tag="BSU16710" /label="mlpA gene" downshifts 1623437 /Source="Nicolas_upshifts" /id="D903" /incds=0 /nref=140 /ntot=219 /MaxReadThrough="1.31218" /MaxDrop="4.84427" /score="15.1952611" /energy="-12.6" /TU="NA" /idTUdmin="U1336" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1623477..1623482 /Source="Nicolas_upshift_promotors" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1623492 /Source="Nicolas_upshifts" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1623498..1623516 /Source="Nicolas_upshift_promotors" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1623526..1623783 /gene="ymxH" /locus_tag="BSU_16720" /old_locus_tag="BSU16720" /experiment="publication(s) with functional evidences, PMID:23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23396918; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="PRC barrel protein involved in sporulation" /protein_id="NP_389554.1" /db_xref="EnsemblGenomes-Gn:BSU16720" /db_xref="EnsemblGenomes-Tr:CAB13545" /db_xref="GOA:Q04811" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR014238" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG10780" /db_xref="UniProtKB/Swiss-Prot:Q04811" /translation="MRLSELSGKEIVDIKRAERLGVLGQTDLEINEQDGQITALLIPT VKWFGLRKQGHDIRVPWHHIQKIGSDMIILDVPEEMPPRQE*" /label="ymxH CDS" gene 1623526..1623783 /gene="ymxH" /locus_tag="BSU_16720" /old_locus_tag="BSU16720" /label="ymxH gene" S_feature 1623784..1623838 /Source="Nicolas_S_feature" /locus_tag="new_1744182_1744236" /HighExp="S4, S3, S5, S6, S8, S7, B36, BT, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S597" downshifts 1623811 /Source="Nicolas_upshifts" /id="D904" /incds=0 /nref=41 /ntot=56 /MaxReadThrough="0.534319999999999" /MaxDrop="6.36032" /score="29.434739" /energy="-11.7" /TU="NA" /idTUdmin="U1340" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1623880..1623889 /Source="Nicolas_upshift_promotors" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="promotor_-35" S_feature 1623899..1623968 /Source="Nicolas_S_feature" /locus_tag="new_1744297_1744366" /HighExp="S6, S8, S7, BT, B36, S5, G/S, Pyr, B60, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S598" upshifts 1623899 /Source="Nicolas_upshifts" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="upshifts" promotor_-10 1623903..1623922 /Source="Nicolas_upshift_promotors" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="promotor_-10" CDS 1623969..1624862 /gene="spoVFA" /locus_tag="BSU_16730" /old_locus_tag="BSU16730" /EC_number="1.3.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8098035, 8345520, 16707666, 25402593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 8345520, 16707666, 25402593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore dipicolinate synthase subunit A" /protein_id="NP_389555.1" /db_xref="EnsemblGenomes-Gn:BSU16730" /db_xref="EnsemblGenomes-Tr:CAB13546" /db_xref="GOA:Q04809" /db_xref="InterPro:IPR007698" /db_xref="InterPro:IPR014215" /db_xref="InterPro:IPR031629" /db_xref="InterPro:IPR036291" /db_xref="PDB:2RIR" /db_xref="SubtiList:BG10781" /db_xref="UniProtKB/Swiss-Prot:Q04809" /translation="MLTGLKIAVIGGDARQLEIIRKLTEQQADIYLVGFDQLDHGFTG AVKCNIDEIPFQQIDSIILPVSATTGEGVVSTVFSNEEVVLKQDHLDRTPAHCVIFSG ISNAYLENIAAQAKRKLVKLFERDDIAIYNSIPTVEGTIMLAIQHTDYTIHGSQVAVL GLGRTGMTIARTFAALGANVKVGARSSAHLARITEMGLVPFHTDELKEHVKDIDICIN TIPSMILNQTVLSSMTPKTLILDLASRPGGTDFKYAEKQGIKALLAPGLPGIVAPKTA GQILANVLSKLLAEIQAEEGK*" /label="spoVFA CDS" gene 1623969..1624862 /gene="spoVFA" /locus_tag="BSU_16730" /old_locus_tag="BSU16730" /label="spoVFA gene" CDS 1624865..1625467 /gene="spoVFB" /locus_tag="BSU_16740" /old_locus_tag="BSU16740" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 8345520, 16707666, 25402593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 8345520, 16707666, 25402593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore dipicolinate synthase subunit B" /protein_id="NP_389556.1" /db_xref="EnsemblGenomes-Gn:BSU16740" /db_xref="EnsemblGenomes-Tr:CAB13547" /db_xref="GOA:Q04810" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR014214" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG10782" /db_xref="UniProtKB/Swiss-Prot:Q04810" /translation="MSSLKGKRIGFGLTGSHCTYEAVFPQIEELVNEGAEVRPVVTFN VKSTNTRFGEGAEWVKKIEDLTGYEAIDSIVKAEPLGPKLPLDCMVIAPLTGNSMSKL ANAMTDSPVLMAAKATIRNNRPVVLGISTNDALGLNGTNLMRLMSTKNIFFIPFGQDD PFKKPNSMVAKMDLLPQTIEKALMHQQLQPILVENYQGND*" /label="spoVFB CDS" gene 1624865..1625467 /gene="spoVFB" /locus_tag="BSU_16740" /old_locus_tag="BSU16740" /label="spoVFB gene" misc_feature 1625521..1625540 /Source="Nicolas_upshift_promotors" /id="U1342" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.781218781218781" /xcortree=1233 /SigmaFactorBS="tgactaaatttacagaaaatctttcccaaactaaaaaattcg gtcatcacccgcatattcTATGGTAAAATAAAACGTAAaatcatagtcaaatcaattc a" /listShort="S599, asd, S600, dapG, dapA, rnjB, tepA, ylzJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1625521..1625592 /Source="Nicolas_S_feature" /locus_tag="new_1745919_1745990" /HighExp="S6, S7, S8, C90, S5, BT, MG 45, MG 5, SMM, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.781, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S599" upshifts 1625521 /Source="Nicolas_upshifts" /id="U1342" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.781218781218781" /xcortree=1233 /SigmaFactorBS="tgactaaatttacagaaaatctttcccaaactaaaaaattcg gtcatcacccgcatattcTATGGTAAAATAAAACGTAAaatcatagtcaaatcaattc a" /listShort="S599, asd, S600, dapG, dapA, rnjB, tepA, ylzJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1625593..1626633 /gene="asd" /locus_tag="BSU_16750" /old_locus_tag="BSU16750" /EC_number="1.2.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 12682299, 25355936, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 12682299, 25355936, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate-semialdehyde dehydrogenase" /protein_id="NP_389557.1" /db_xref="EnsemblGenomes-Gn:BSU16750" /db_xref="EnsemblGenomes-Tr:CAB13548" /db_xref="GOA:Q04797" /db_xref="InterPro:IPR000319" /db_xref="InterPro:IPR000534" /db_xref="InterPro:IPR005986" /db_xref="InterPro:IPR012080" /db_xref="InterPro:IPR012280" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10783" /db_xref="UniProtKB/Swiss-Prot:Q04797" /translation="MGRGLHVAVVGATGAVGQQMLKTLEDRNFEMDTLTLLSSKRSAG TKVTFKGQELTVQEASPESFEGVNIALFSAGGSVSQALAPEAVKRGAIVIDNTSAFRM DENTPLVVPEVNEADLHEHNGIIANPNCSTIQMVAALEPIRKAYGLNKVIVSTYQAVS GAGNEAVKELYSQTQAILNKEEIEPEIMPVKGDKKHYQIAFNAIPQIDKFQDNGYTFE EMKMINETKKIMHMPDLQVAATCVRLPIQTGHSESVYIEIDRDDATVEDIKNLLKEAP GVTLQDDPSQQLYPMPADAVGKNDVFVGRIRKDLDRANGFHLWVVSDNLLKGAAWNSV QIAESLKKLNLV*" /label="asd CDS" gene 1625593..1626633 /gene="asd" /locus_tag="BSU_16750" /old_locus_tag="BSU16750" /label="asd gene" S_feature 1626634..1626724 /Source="Nicolas_S_feature" /locus_tag="new_1747032_1747122" /HighExp="S7, S6, S8, LBGtran, GM 120, dia15, Heat, LBGstat, GM 90, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.781, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S600" CDS 1626725..1627939 /gene="dapG" /locus_tag="BSU_16760" /old_locus_tag="BSU16760" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1906928, 8098035" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1906928, 8098035; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase I (alpha and beta subunits)" /protein_id="NP_389558.2" /db_xref="EnsemblGenomes-Gn:BSU16760" /db_xref="EnsemblGenomes-Tr:CAB13549" /db_xref="GOA:Q04795" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001341" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005260" /db_xref="InterPro:IPR018042" /db_xref="InterPro:IPR027795" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10784" /db_xref="UniProtKB/Swiss-Prot:Q04795" /translation="MKIIVQKFGGTSVKDDKGRKLALGHIKEAISEGYKVVVVVSAMG RKGDPYATDSLLGLLYGDQSAISPREQDLLLSCGETISSVVFTSMLLDNGVKAAALTG AQAGFLTNDQHTNAKIIEMKPERLFSVLANHDAVVVAGFQGATEKGDTTTIGRGGSDT SAAALGAAVDAEYIDIFTDVEGVMTADPRVVENAKPLPVVTYTEICNLAYQGAKVISP RAVEIAMQAKVPIRVRSTYSNDKGTLVTSHHSSKVGSDVFERLITGIAHVKDVTQFKV PAKIGQYNVQTEVFKAMANAGISVDFFNITPSEIVYTVAGNKTETAQRILMDMGYDPM VTRNCAKVSAVGAGIMGVPGVTSKIVSALSEKEIPILQSADSHTTIWVLVHEADMVPA VNALHEVFELSK*" /label="dapG CDS" gene 1626725..1627939 /gene="dapG" /locus_tag="BSU_16760" /old_locus_tag="BSU16760" /label="dapG gene" CDS 1627970..1628842 /gene="dapA" /locus_tag="BSU_16770" /old_locus_tag="BSU16770" /EC_number="4.3.3.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 9298659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 9298659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-hydroxy-tetrahydrodipicolinate synthase" /protein_id="NP_389559.1" /db_xref="EnsemblGenomes-Gn:BSU16770" /db_xref="EnsemblGenomes-Tr:CAB13550" /db_xref="GOA:Q04796" /db_xref="InterPro:IPR002220" /db_xref="InterPro:IPR005263" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR020624" /db_xref="InterPro:IPR020625" /db_xref="SubtiList:BG10785" /db_xref="UniProtKB/Swiss-Prot:Q04796" /translation="MNFGNVSTAMITPFDNKGNVDFQKLSTLIDYLLKNGTDSLVVAG TTGESPTLSTEEKIALFEYTVKEVNGRVPVIAGTGSNNTKDSIKLTKKAEEAGVDAVM LVTPYYNKPSQEGMYQHFKAIAAETSLPVMLYNVPGRTVASLAPETTIRLAADIPNVV AIKEASGDLEAITKIIAETPEDFYVYSGDDALTLPILSVGGRGVVSVASHIAGTDMQQ MIKNYTNGQTANAALIHQKLLPIMKELFKAPNPAPVKTALQLRGLDVGSVRLPLVPLT EDERLSLSSTISEL*" /label="dapA CDS" gene 1627970..1628842 /gene="dapA" /locus_tag="BSU_16770" /old_locus_tag="BSU16770" /label="dapA gene" S_feature complement(1628313..1629497) /Source="Nicolas_S_feature" /locus_tag="new_1748711_1749895_c" /HighExp="S8, S6, S4, S5, S7, S3, LoTm, T5.0H, BT, C30" /AntisenseName="dapA" /AntisenseCor="0.13444126275526899" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S601" downshifts 1628849 /Source="Nicolas_upshifts" /id="D905" /incds=0 /nref=17 /ntot=99 /MaxReadThrough="6.0497" /MaxDrop="5.05122" /score="24.080775" /energy="-11.7" /TU="U1342" /idTUdmin="U1341" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1628942..1628945 /Source="Nicolas_upshift_promotors" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1628959 /Source="Nicolas_upshifts" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1628961..1628980 /Source="Nicolas_upshift_promotors" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1629020..1630687 /gene="rnjB" /locus_tag="BSU_16780" /old_locus_tag="BSU16780" /EC_number="3.1.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15831787, 18713320, 20025672, 20729365, 24187087, 26296725, 28384222" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15831787, 18713320, 20025672, 20729365, 24187087, 26296725, 28384222; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dual activity 5' exo-and endoribonuclease J2" /protein_id="NP_389560.2" /db_xref="EnsemblGenomes-Gn:BSU16780" /db_xref="EnsemblGenomes-Tr:CAB13551" /db_xref="GOA:O31760" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR004613" /db_xref="InterPro:IPR011108" /db_xref="InterPro:IPR030854" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13422" /db_xref="UniProtKB/Swiss-Prot:O31760" /translation="MKKKNTENVRIIALGGVGEIGKNLYVIEIDSDIFVVDAGLMHPE NEMLGIDVVIPDISYLIERADRVKAIFLTHGHDENIGGVFYLLNKLSVPVYGTKLTLA LLREKLKQYGHNRKTDLREIHSKSVITFESTKVSFFRTIHSIPDSVGVSFKTSLGSIV CTGDFKFDQTPALNQTCDIGEIAKIGNSGVLALLSDSANAERPGYTPSEAAVSGEISD ALYNSQNRVIIAVFASNINRIQQVIHAAAQNGRKIAVAGKNLQSVLQLARKLGYIEAD DELFISVQDVKKYPKREVAIITAGSQGEPLAALTRMANKAHKQLNIEEGDTVVIASTP IPGQELIYSKTVDLLARAGAQVIFAQKRVHVSGHGSQEELKLMINLLKPKYLIPVNGE YRMQKAHSKIAEETGMKRSDIFLIEKGDVVEFRGQNVKIGDKVPYGNILIDGLGVGDI GNIVLRDRRLLSQDGILIVVITLDKQKKHLVSGPEIITRGFVYVRESEGLIVQATELV RSIVTEATETSNVEWSTLKQAMRDALNQFLYEKTKRKPMIIPIIMEV*" /label="rnjB CDS" gene 1629020..1630687 /gene="rnjB" /locus_tag="BSU_16780" /old_locus_tag="BSU16780" /label="rnjB gene" promotor_-10 complement(1629484..1629502) /Source="Nicolas_upshift_promotors" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1629501) /Source="Nicolas_upshifts" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1629518..1629523) /Source="Nicolas_upshift_promotors" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1630675 /Source="Nicolas_upshifts" /id="D906" /incds=0 /nref=227 /ntot=263 /MaxReadThrough="4.0072" /MaxDrop="6.75416" /score="24.080775" /energy="-11.7" /TU="U1342" /idTUdmin="U1343" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1630742..1630748 /Source="Nicolas_upshift_promotors" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="promotor_-35" promotor_-10 1630762..1630773 /Source="Nicolas_upshift_promotors" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="promotor_-10" upshifts 1630763 /Source="Nicolas_upshifts" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="upshifts" CDS 1630803..1631540 /gene="tepA" /locus_tag="BSU_16790" /old_locus_tag="BSU16790" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10455123, 15189290, 23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10455123, 15189290, 23927687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein export-enhancing protease (spore outgrowth)" /protein_id="NP_389561.3" /db_xref="EnsemblGenomes-Gn:BSU16790" /db_xref="EnsemblGenomes-Tr:CAB13552" /db_xref="GOA:Q99171" /db_xref="InterPro:IPR023562" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG11055" /db_xref="UniProtKB/Swiss-Prot:Q99171" /translation="MDHRMENTEEERPEKNDAKDSIMNKIQQLGETTLPQLPQDTNIH CLTIIGQIEGHVQLPPQNKTTKYEHVIPQIVAIEQNPKIEGLLIILNTVGGDVEAGLA IAEMLASLSKPTVSIVLGGGHSIGVPIAVSCDYSYIAETATMTIHPVRLTGLVIGVPQ TFEYLDKMQERVVKFVTSHSNITEEKFKELMFSKGNLTRDIGTNVVGKDAVKYGLIDH AGGVGQAINKLNELIDEARKEEGRMIQ*" /label="tepA CDS" gene 1630803..1631540 /gene="tepA" /locus_tag="BSU_16790" /old_locus_tag="BSU16790" /label="tepA gene" CDS 1631537..1631749 /gene="tepJ" /locus_tag="BSU_16799" /old_locus_tag="BSU16799" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23927687; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modulator of TepA activity (spore outgrowth)" /protein_id="YP_003097729.1" /db_xref="EnsemblGenomes-Gn:BSU16799" /db_xref="EnsemblGenomes-Tr:CAX52620" /db_xref="InterPro:IPR025619" /db_xref="UniProtKB/Swiss-Prot:C0H413" /translation="MILYTVMPQEIVFAEQNQETSAHEQIEYKGVPLLVEMKGNEAEV IQIMSTNPMHFLHPDISPGQKLKLNV*" /label="tepJ CDS" gene 1631537..1631749 /gene="tepJ" /locus_tag="BSU_16799" /old_locus_tag="BSU16799" /label="tepJ gene" misc_feature 1631777..1631796 /Source="Nicolas_upshift_promotors" /id="U1346" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=2128 /SigmaFactorBS="gctgaaattaaacgtataagaatccaacccttttttaagggc aaaaTATGCTATAATAGGGGAATCctacagaaaaaacgcagcctgtaaacggctgctt t" /listShort="spoIIIE, S602, ymfC" /listLong="ymfD" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1631791 /Source="Nicolas_upshifts" /id="U1346" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=2128 /SigmaFactorBS="gctgaaattaaacgtataagaatccaacccttttttaagggc aaaaTATGCTATAATAGGGGAATCctacagaaaaaacgcagcctgtaaacggctgctt t" /listShort="spoIIIE, S602, ymfC" /listLong="ymfD" /label="upshifts" CDS 1631880..1634243 /gene="spoIIIE" /locus_tag="BSU_16800" /old_locus_tag="BSU16800" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11062134, 11778051, 12618465, 16430687, 17139259, 17322320, 18160039, 24297254, 24769697, 26452092; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore DNA directional translocase (motor ATPase)" /protein_id="NP_389562.3" /db_xref="EnsemblGenomes-Gn:BSU16800" /db_xref="EnsemblGenomes-Tr:CAB13553" /db_xref="GOA:P21458" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR018541" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10763" /db_xref="UniProtKB/Swiss-Prot:P21458" /translation="MAKKKRKSRKKQAKQLNIKYELNGLLCIAISIIAILQLGVVGQT FIYLFRFFAGEWFILCLLGLLVLGVSLFWKKKTPSLLTRRKAGLYCIIASILLLSHVQ LFKNLTHKGSIESASVVRNTWELFLMDMNGSSASPDLGGGMIGALLFAASHFLFASTG SQIMAIVMILIGMILVTGRSLQETLKKWMSPIGRFIKEQWLAFIDDMKSFKSNMQSSK KTKAPSKKQKPARKKQQMEPEPPDEEGDYETVSPLIHSEPIISSFSDRNEEEESPVIE KRAEPVSKPLQDIQPETGDQETVSAPPMTFTELENKDYEMPSLDLLADPKHTGQQADK KNIYENARKLERTFQSFGVKAKVTQVHLGPAVTKYEVYPDVGVKVSKIVNLSDDLALA LAAKDIRIEAPIPGKSAIGIEVPNAEVAMVSLKEVLESKLNDRPDAKLLIGLGRNISG EAVLAELNKMPHLLVAGATGSGKSVCVNGIITSILMRAKPHEVKMMMIDPKMVELNVY NGIPHLLAPVVTDPKKASQALKKVVNEMERRYELFSHTGTRNIEGYNDYIKRANNEEG AKQPELPYIVVIVDELADLMMVASSDVEDSITRLSQMARAAGIHLIIATQRPSVDVIT GVIKANIPSRIAFSVSSQTDSRTILDMGGAEKLLGRGDMLFLPVGANKPVRVQGAFLS DDEVEKVVDHVITQQKAQYQEEMIPEETTETHSEVTDELYDEAVELIVGMQTASVSML QRRFRIGYTRAARLIDAMEERGVVGPYEGSKPREVLLSKEKYDELSS*" /label="spoIIIE CDS" gene 1631880..1634243 /gene="spoIIIE" /locus_tag="BSU_16800" /old_locus_tag="BSU16800" /label="spoIIIE gene" S_feature 1634244..1634344 /Source="Nicolas_S_feature" /locus_tag="new_1754642_1754742" /HighExp="Cold, C30, G135, Lbstat, BC, G180, G150, S8, LoTm, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.109246" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S602" promotor_-35 1634305..1634312 /Source="Nicolas_upshift_promotors" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1634327..1634346 /Source="Nicolas_upshift_promotors" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1634345 /Source="Nicolas_upshifts" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="upshifts" CDS 1634387..1635112 /gene="ymfC" /locus_tag="BSU_16810" /old_locus_tag="BSU16810" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family,possibly involved in biofilm formation)" /protein_id="NP_389563.1" /db_xref="EnsemblGenomes-Gn:BSU16810" /db_xref="EnsemblGenomes-Tr:CAB13554" /db_xref="GOA:O31761" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13423" /db_xref="UniProtKB/Swiss-Prot:O31761" /translation="MSTKADNRHLYLKVIERIKEDIKNGIYTEKEKLPSEFELSKKLG VSRATLREALRILEEEHVIIRRHGVGTFVHSKPLFLSGIEQLNSVTKMIEQANMTPGT IFLSSQVLMPSEDDTKRFHLAEGQELFYLERVRTADGQPIVYCIDKIPMNILPNSFSH QQESMFDLLEKNSGSVISYAVTDIEPIGYHDTISPVLECDPETALLLLKQTHYDQHDK PVLYSLNYFRADKFRFHVLRKRF*" /label="ymfC CDS" gene 1634387..1635112 /gene="ymfC" /locus_tag="BSU_16810" /old_locus_tag="BSU16810" /label="ymfC gene" downshifts 1635099 /Source="Nicolas_upshifts" /id="D907" /incds=0 /nref=135 /ntot=256 /MaxReadThrough="4.863" /MaxDrop="4.01593" /score="16.3235883" /energy="-7.2" /TU="U1346,U1347" /idTUdmin="U1346" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-35 1635168..1635174 /Source="Nicolas_upshift_promotors" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1635187 /Source="Nicolas_upshifts" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1635189..1635200 /Source="Nicolas_upshift_promotors" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1635251..1636459 /gene="bcbE" /locus_tag="BSU_16825" /old_locus_tag="BSU16825" /function="7: Transport and binding proteins" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18502870, 27375568" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18502870, 27375568; Product type t: transporter" /codon_start=1 /transl_table=11 /product="bacillibactin exporter" /protein_id="NP_389564.2" /db_xref="EnsemblGenomes-Gn:BSU16825" /db_xref="EnsemblGenomes-Tr:CAB13555" /db_xref="GOA:O31762" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13424" /db_xref="UniProtKB/Swiss-Prot:O31762" /translation="MKNIIALSSVPLVMTLGNSMLIPVLPMMEKKLSVTSFQVSLIIT VYSVVAIICIPIAGYLSDRFGRKKILLPCLLIAGLGGAVAAFASTYMKNPYAMILAGR VLQGIGSAGAAPIVMPFIGDLFKGDDEKVSAGLGDIETANTSGKVLSPILGALLASWY WFVPFWFIPFFCLISFLLVLFLVAKPEEDEDAPAVSEFIKSVKKIFKQDGRWLYTVFI IGCVIMFLLFGVLFYLSDTLENKYAIDGVAKGGLLAIPLLFLSTSSFIAGKKIGKDKG RMKFCVVTGMILLTLSFIALWWNHSFYFLFVFLSFGGIGIGMALPALDALITEGIESE QCGTISSFYNSMRFIGVALGPPVFAALMSNANWIIFILSAFCSIVSLFLVLFTVDAKK SEEEKNLGTV*" /label="bcbE CDS" gene 1635251..1636459 /gene="bcbE" /locus_tag="BSU_16825" /old_locus_tag="BSU16825" /label="bcbE gene" downshifts 1636417 /Source="Nicolas_upshifts" /id="D908" /incds=0 /nref=1 /ntot=32 /MaxReadThrough="1.34389" /MaxDrop="3.00655" /score="5.64651968" /energy="-6.7" /TU="NA" /idTUdmin="U1348" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1636528..1636535 /Source="Nicolas_upshift_promotors" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1636548..1636567 /Source="Nicolas_upshift_promotors" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1636570 /Source="Nicolas_upshifts" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" promotor_-35 1636582..1636585 /Source="Nicolas_upshift_promotors" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1636601..1636613 /Source="Nicolas_upshift_promotors" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1636615 /Source="Nicolas_upshifts" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1636639..1637919 /gene="ymfF" /locus_tag="BSU_16845" /old_locus_tag="BSU16845" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metalloprotease" /protein_id="NP_389566.2" /db_xref="EnsemblGenomes-Gn:BSU16845" /db_xref="EnsemblGenomes-Tr:CAB13557" /db_xref="GOA:O31764" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="SubtiList:BG13426" /db_xref="UniProtKB/Swiss-Prot:O31764" /translation="MSYVNELKSKHGGLTAHIVKTEKFKTVSLIFKMLAPLTKDQVTK RALLPHVLLRGTKSHPKTAGLRSYLDELYGTSVSADLTKKGERHVITFRLEIPNEKYL KDQTPLLEKGLQLLAELVFSPALEGDAFQSQYVAQEKRTLKQRIQAVYDDKMRYSNLR LIQEMCKNDPYALHVNGEIDDVDDITAEQLYETYQSAIQKDQLDLYVVGDVDSNQVQS AIDKYFKTEERTLGMIENNHADEKVQPKEVIDEEDVKQGKLNIGYRTSITYTDQDYPA LQVFNGLFGGFSHSKLFINVREKASLAYYAASRIESFKGLLMVMSGIEVKNFEQAVSI IAEQFQAMKNGDFSEQDIAQTKAVIRNQVLETIDTAYGLSEFLYQQAAAQVEIPIEDF LANIENVTKEDIIKAGEKIQLDTTYFLKGTEGAS*" /label="ymfF CDS" gene 1636639..1637919 /gene="ymfF" /locus_tag="BSU_16845" /old_locus_tag="BSU16845" /label="ymfF gene" CDS 1637916..1639202 /gene="ymfH" /locus_tag="BSU_16860" /old_locus_tag="BSU16860" /EC_number="3.4.24.-" /function="16.6: Maintain" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative processing protease" /protein_id="NP_389568.2" /db_xref="EnsemblGenomes-Gn:BSU16860" /db_xref="EnsemblGenomes-Tr:CAB13559" /db_xref="GOA:O31766" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR011765" /db_xref="SubtiList:BG13428" /db_xref="UniProtKB/Swiss-Prot:O31766" /translation="MIKPIEYEQLQETLYHEKMSNGLDVYVLPKKGFNKTYAVFTTKY GSIDNRFVPLGKNEMVHVPDGIAHFLEHKLFEKADGDVFQDFSKQGASANAFTSFTRT AYLFSSTSNVERNLETLIDFVQDPYFTEKTVEKEKGIIGQEINMYDDNPDWRLYFGVI ENMYKEHPVRIDIAGTVESISHITKDLLYECYETFYHPSNMLLFIVGPVDPEAIISQV RENQGKKPYTDQPEIKREEVKEQEAVFRKEKEIKMNVQGPKCLVGLKSKNPFKLGKEL LKHELSMNLLLEALFGKSSAQYESLYEKGYIDETFSFDFTAEYGFGFAAIGGDTPEPD QLAEDISSMLLRAGELITAEKIELARKKKIGTFLKALNSPEYIANQFTRYAFLDMSLF DVVTVLEQITLEDVQNVIQEEIAADRLTVCKVVPKS*" /label="ymfH CDS" gene 1637916..1639202 /gene="ymfH" /locus_tag="BSU_16860" /old_locus_tag="BSU16860" /label="ymfH gene" downshifts 1639052 /Source="Nicolas_upshifts" /id="D909" /incds=1 /nref=10 /ntot=159 /MaxReadThrough="5.673" /MaxDrop="3.16735" /score="1.51160893" /energy="-10.4" /TU="U1349,U1350" /idTUdmin="U1350" /TUdmin="-1256" /isTUend="FALSE" /label="downshifts" S_feature 1639203..1639256 /Source="Nicolas_S_feature" /locus_tag="new_1759601_1759654" /HighExp="Etha, dia15, H2O2, G135, G150, G180, Paraq, LBGexp, Oxctl, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.431, 0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S603" CDS 1639257..1639985 /gene="efpI" /locus_tag="BSU_16870" /old_locus_tag="BSU16870" /EC_number="1.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15066026, 28787546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 28787546; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="EF-P-5 aminopentanone reductase (EF-P repair enzyme), NADPH-dependent" /protein_id="NP_389569.2" /db_xref="EnsemblGenomes-Gn:BSU16870" /db_xref="EnsemblGenomes-Tr:CAB13560" /db_xref="GOA:O31767" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13429" /db_xref="UniProtKB/Swiss-Prot:O31767" /translation="MNKTALITGASGGIGKSISETLAARGYNLLLHYNTNQNAAAELA EKLSQMFGVNAEILQADLSAQDGADKLTSSIVQPIDAIVLNSGRSHFGLITDVDNATV QEMVQLHVASPYMLTRNLLPGMIRNKSGAIVAVSSIWGETGASCEVLYSMAKGAQHSF VKGLAKELAPSGIRVNAVAPGAVDTNMMNQFTPAEKEEIADEIPIGRLARPQEIADAT AFLLSEKASYITGQILSVNGGWHC*" /label="efpI CDS" gene 1639257..1639985 /gene="efpI" /locus_tag="BSU_16870" /old_locus_tag="BSU16870" /label="efpI gene" promotor_-35 1640001..1640007 /Source="Nicolas_upshift_promotors" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1640019 /Source="Nicolas_upshifts" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1640021..1640032 /Source="Nicolas_upshift_promotors" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1640032) /Source="Nicolas_upshifts" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1640043..1640057) /Source="Nicolas_upshift_promotors" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1640066..1640070) /Source="Nicolas_upshift_promotors" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1640066..1640323 /gene="ymfJ" /locus_tag="BSU_16880" /old_locus_tag="BSU16880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389570.1" /db_xref="EnsemblGenomes-Gn:BSU16880" /db_xref="EnsemblGenomes-Tr:CAB13561" /db_xref="InterPro:IPR021637" /db_xref="InterPro:IPR024702" /db_xref="SubtiList:BG13430" /db_xref="UniProtKB/Swiss-Prot:O31768" /translation="MSVLENWDSWKNFLGDRLNYAQDKGMSQDTITDLATEIGSYLAN EVESKNEQEKVLADLWSVASKDEQHAIANMMVKLVENNSTH*" /label="ymfJ CDS" gene 1640066..1640323 /gene="ymfJ" /locus_tag="BSU_16880" /old_locus_tag="BSU16880" /label="ymfJ gene" downshifts 1640308 /Source="Nicolas_upshifts" /id="D910" /incds=0 /nref=165 /ntot=250 /MaxReadThrough="4.58488" /MaxDrop="7.23574" /score="21.9507801" /energy="-8.7" /TU="U1349,U1351" /idTUdmin="U1350" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1640340) /Source="Nicolas_upshifts" /id="D911" /incds=0 /nref=2 /ntot=15 /MaxReadThrough="3.44398" /MaxDrop="3.96475" /score="-6.33040789" /energy="-7.2" /TU="NA" /idTUdmin="U1344" /TUdmin="-11987" /isTUend="FALSE" /label="downshifts" promotor_-35 1640381..1640384 /Source="Nicolas_upshift_promotors" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1640399..1640418 /Source="Nicolas_upshift_promotors" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1640399 /Source="Nicolas_upshifts" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" CDS 1640453..1640968 /gene="ymfKn" /locus_tag="BSU_16890" /old_locus_tag="BSU16890" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein with ACT domain; N-terminal part of YmfK" /db_xref="SubtiList:BG13431" /translation="MAKLEWYFEYEIQVNRPGLLGDISSLLGMLSINIVTINGVDLSR RGMLLRCRHIDQIKRLESILKTMETIKVTKLREPRLRDRLAVRHGRYIQRDADDKKTF RFERDELGLLVDFMAELFKKEGHKLIGIRGMPRVGKTESIVASSVCEQKVAVCVINLA EADDKKPADCR*" /label="ymfKn CDS" gene 1640453..1640968 /gene="ymfKn" /locus_tag="BSU_16890" /old_locus_tag="BSU16890" /pseudo /label="ymfKn gene" CDS 1640904..1641242 /gene="ymfKc" /locus_tag="BSU_16900" /old_locus_tag="BSU16900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein with ACT domain; C-terminal part of YmfK" /db_xref="SubtiList:BG13432" /translation="RWLFVSSTLLKQTIRSQLIADEYSTENVFIVDGIVSTRRGSERH LQLVREIMRLPATKVVEHPDIFVQNTEYTLDDFDYIIELRNDPDEVITYEHAEEPQMF DQSGFSSFDF*" /label="ymfKc CDS" gene 1640904..1641242 /gene="ymfKc" /locus_tag="BSU_16900" /old_locus_tag="BSU16900" /pseudo /label="ymfKc gene" CDS 1641309..1642175 /gene="rodZ" /locus_tag="BSU_16910" /old_locus_tag="BSU16910" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 19164570, 22720735, 23879732, 27415800, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 19164570, 22720735, 23879732, 27415800, 27818647; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell shape determination factor" /protein_id="NP_389573.3" /db_xref="EnsemblGenomes-Gn:BSU16910" /db_xref="EnsemblGenomes-Tr:CAB13564" /db_xref="GOA:O31771" /db_xref="InterPro:IPR025194" /db_xref="SubtiList:BG13433" /db_xref="UniProtKB/Swiss-Prot:O31771" /translation="MSLDDLQAATKIQKRYLTALEEGNYDIIPGKFYVRAFIKQYAEA VGLDADQLFEEHKKDIPNTYHDDVSEKISGMNLQKEMPKPASKALELLPTILVILGVI VVIAIVYAIIQFANHKNSDDHNAASEKAITQSESKYEIPKDSTLKENQNNSSEKETDT KKETKENEDKKKENDSEKLEIKAAGTEGSLTTYEVSGADKIELELKASDSSWIRVRDE NSSSLKEGTLKKDETYKKDITDQKQVDIRTGYAPNLKIKINGKVLSYELDPKKVMAQT IKIVNKKEEKSS*" /label="rodZ CDS" gene 1641309..1642175 /gene="rodZ" /locus_tag="BSU_16910" /old_locus_tag="BSU16910" /label="rodZ gene" promotor_no_box 1641372..1641472 /Source="Nicolas_upshift_promotors" /id="U1354" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.52947052947053" /psig="0.015984015984016" /xcortree=1494 /SigmaFactorBS="gaaggaaactatgacattattccggggaagttttatgttcgg gcattcatcaagcaatatgcagaagccgttgggcttgatgcggatcagctgtttgagg a" /listShort="pgsA, cinA, S604" /listLong="recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_no_box" upshifts 1641432 /Source="Nicolas_upshifts" /id="U1354" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.52947052947053" /psig="0.015984015984016" /xcortree=1494 /SigmaFactorBS="gaaggaaactatgacattattccggggaagttttatgttcgg gcattcatcaagcaatatgcagaagccgttgggcttgatgcggatcagctgtttgagg a" /listShort="pgsA, cinA, S604" /listLong="recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" downshifts 1642135 /Source="Nicolas_upshifts" /id="D912" /incds=0 /nref=1 /ntot=107 /MaxReadThrough="5.43253" /MaxDrop="2.8328" /score="21.9507801" /energy="-8.7" /TU="U1353,U1354" /idTUdmin="U1351" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1642225..1642806 /gene="pgsA" /locus_tag="BSU_16920" /old_locus_tag="BSU16920" /EC_number="2.7.8.5" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15743965, 15849754, 16514141, 16850406, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15743965, 15849754, 16514141, 16850406, 27818647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase" /protein_id="NP_389574.2" /db_xref="EnsemblGenomes-Gn:BSU16920" /db_xref="EnsemblGenomes-Tr:CAB13565" /db_xref="GOA:P46322" /db_xref="InterPro:IPR000462" /db_xref="InterPro:IPR004570" /db_xref="SubtiList:BG11373" /db_xref="UniProtKB/Swiss-Prot:P46322" /translation="MFNLPNKITLARIALIPIFMIIMLAPFDWGRLEVGDESIPVAHL AGAILFIIASTTDWVDGYYARKLNLVTNFGKFLDPLADKLLVSAALIILVQFDLAPAW MVIVIISREFAVTGLRLVLAGTGEVVAANMLGKIKTWAQIIAVSALLLHNLPFELVSF PFADLALWVAVFFTVVSGWEYFSKNWEALKTSN*" /label="pgsA CDS" gene 1642225..1642806 /gene="pgsA" /locus_tag="BSU_16920" /old_locus_tag="BSU16920" /label="pgsA gene" CDS 1642824..1644074 /gene="cinA" /locus_tag="BSU_16930" /old_locus_tag="BSU16930" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10438773, 11703670, 20480359; Product type r: regulator" /codon_start=1 /transl_table=11 /product="competence-damage inducible regulator" /protein_id="NP_389575.2" /db_xref="EnsemblGenomes-Gn:BSU16930" /db_xref="EnsemblGenomes-Tr:CAB13566" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR008135" /db_xref="InterPro:IPR008136" /db_xref="InterPro:IPR036425" /db_xref="InterPro:IPR036653" /db_xref="SubtiList:BG11374" /db_xref="UniProtKB/Swiss-Prot:P46323" /translation="MEFPKKAEIIAVGSELLLGQIANTNAQFISKQLAEIGVNVFYHT AVGDNPERLKQVIRIAEERSDFIIFSGGLGPTKDDLTKETIANTLGRPLVLNDEAFQS IEDYFKRTKRTMSPNNRKQALVIEGSDVLANHFGMAPGMLTEHESRYYMLLPGPPSEL RPMFENEAKPLLLKKMGSNEKIVSTVLRFFGIGESQLEADLEDIIDAQTNPTIAPLAA DGEVTLRLTAKHADEKETERLLKETEAVILERVGEFFYGYDDTSLVKELSIACKEKGI TISAAESFTGGLFSEWLTDHSGASKLFAGGVVCYTNDVKQNVLGVKKETLDRFGAVSK ECASELAKGVQKLTGSDIGISFTGVAGPDAQEGHEPGHVFIGISANGKEEVHEFHFAG SRTGIRKRGAKYGCHLILKLLEQK*" /label="cinA CDS" gene 1642824..1644074 /gene="cinA" /locus_tag="BSU_16930" /old_locus_tag="BSU16930" /label="cinA gene" S_feature 1644075..1644201 /Source="Nicolas_S_feature" /locus_tag="new_1764473_1764599" /HighExp="LBGstat, LBGtran, G135, Lbstat, G150, C30, LBGexp, dia0, S0, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.016, 0.998" /TUlongSig="SigA" /TUlongPSig="0.987" /label="S604" promotor_-35 1644181..1644188 /Source="Nicolas_upshift_promotors" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1644203..1644222 /Source="Nicolas_upshift_promotors" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1644203 /Source="Nicolas_upshifts" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" CDS 1644247..1645293 /gene="recA" /locus_tag="BSU_16940" /old_locus_tag="BSU16940" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11555642, 16024744, 16061691, 16267290, 17229847, 22720735, 25939832, 26001966, 26930481, 28344191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555642, 16024744, 16061691, 16267290, 17229847, 22720735, 25939832, 26001966, 26930481, 28344191; Product type f: factor" /codon_start=1 /transl_table=11 /product="multifunctional SOS repair factor" /protein_id="NP_389576.2" /db_xref="EnsemblGenomes-Gn:BSU16940" /db_xref="EnsemblGenomes-Tr:CAB13567" /db_xref="GOA:P16971" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013765" /db_xref="InterPro:IPR020584" /db_xref="InterPro:IPR020587" /db_xref="InterPro:IPR020588" /db_xref="InterPro:IPR023400" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10721" /db_xref="UniProtKB/Swiss-Prot:P16971" /translation="MSDRQAALDMALKQIEKQFGKGSIMKLGEKTDTRISTVPSGSLA LDTALGIGGYPRGRIIEVYGPESSGKTTVALHAIAEVQQQGGQAAFIDAEHALDPVYA QKLGVNIEELLLSQPDTGEQALEIAEALVRSGAVDIVVVDSVAALVPKAEIEGDMGDS HVGLQARLMSQALRKLSGAINKSKTIAIFINQIREKVGVMFGNPETTPGGRALKFYSS VRLEVRRAEQLKQGNDVMGNKTKIKVVKNKVAPPFRTAEVDIMYGEGISKEGEIIDLG TELDIVQKSGSWYSYEEERLGQGRENAKQFLKENKDIMLMIQEQIREHYGLDNNGVVQ QQAEETQEELEFEE*" /label="recA CDS" gene 1644247..1645293 /gene="recA" /locus_tag="BSU_16940" /old_locus_tag="BSU16940" /label="recA gene" downshifts 1645305 /Source="Nicolas_upshifts" /id="D913" /incds=0 /nref=201 /ntot=262 /MaxReadThrough="4.54659" /MaxDrop="9.405" /score="23.91264" /energy="-9.7" /TU="U1355" /idTUdmin="U1353" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature 1645350..1645415 /Source="Nicolas_S_feature" /locus_tag="new_1765748_1765813" /HighExp="S7, S5, S8, S4, H2O2, C30, T5.0H, S6, ferm, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="Sig-, SigA, SigA" /TUlongPSig="0.016, 0.998, 0.987" /label="S605" promotor_-35 1645387..1645396 /Source="Nicolas_upshift_promotors" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1645409..1645424 /Source="Nicolas_upshift_promotors" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="promotor_-10" upshifts 1645417 /Source="Nicolas_upshifts" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="upshifts" CDS 1645461..1646636 /gene="pbpX" /locus_tag="BSU_16950" /old_locus_tag="BSU16950" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14762009, 15758244, 21856855" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762009, 15758244, 21856855; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding endopeptidase X (lysozyme resistance)" /protein_id="NP_389577.1" /db_xref="EnsemblGenomes-Gn:BSU16950" /db_xref="EnsemblGenomes-Tr:CAB13568" /db_xref="GOA:O31773" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="SubtiList:BG12642" /db_xref="UniProtKB/Swiss-Prot:O31773" /translation="MTSPTRRRTAKRRRRKLNKRGKLLFGLLAVMVCITIWNALHRNS EENEPSQETAAVSNTDQKKEVKKKTAKKSEEQIKTVDRNQKISNYLKEIGFSGTAMIV RNGEIVTNKGFGYADRKHYIQNNPLTSFYVGSSQKALIATAILQLEEKGKLQTSDPVS TYLPHFPNGQTITLKNLLTHTSGINGHIEGNGAITPDDLIKDIELQGIKRQPGVWDYK DSNYSVLAYIIAEVSGEPYEQYIKNHIFKPAGMTHAGFYKTYEKEPYPAVGYKMEGSK TVTPYIPDLSQLYGAGDIYMSAIDMYKFDQALIDGKLYSQKSYEKMFTPGSSSTYGMG FYVAPGSYSNHGVMPGFNILNSFSKSGQTIVILFSNIQNNAKLGQVNNKIYQLLNQE* " /label="pbpX CDS" gene 1645461..1646636 /gene="pbpX" /locus_tag="BSU_16950" /old_locus_tag="BSU16950" /label="pbpX gene" S_feature 1646637..1646736 /Source="Nicolas_S_feature" /locus_tag="new_1767035_1767134" /HighExp="dia0, LBGexp, Lbexp, Oxctl, Paraq, H2O2, C30, G150, Mt0, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.54369999999999996" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA, Sig-, SigA, SigA" /TUlongPSig="1, 0.016, 0.998, 0.987" /label="S606" promotor_-35 1646710..1646717 /Source="Nicolas_upshift_promotors" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1646731..1646750 /Source="Nicolas_upshift_promotors" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="promotor_-10" S_feature 1646738..1646911 /Source="Nicolas_S_feature" /locus_tag="new_1767136_1767309" /HighExp="M9-stat, T3.30H, BC, T2.0H, T3.0H, T-1.40H, T1.30H, T2.30H, T4.0H, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY, SigA, Sig-, SigA, SigA" /TUlongPSig="1, 1, 0.016, 0.998, 0.987" /label="S607" upshifts 1646738 /Source="Nicolas_upshifts" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="upshifts" CDS 1646912..1648474 /gene="rny" /locus_tag="BSU_16960" /old_locus_tag="BSU16960" /EC_number="3.1.26.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 19779461, 21803996, 21815947, 21862575, 22720735, 25402410, 26797123" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 19779461, 21803996, 21815947, 21862575, 22720735, 25402410, 26797123; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endoribonuclease Y" /protein_id="NP_389578.1" /db_xref="EnsemblGenomes-Gn:BSU16960" /db_xref="EnsemblGenomes-Tr:CAB13569" /db_xref="GOA:O31774" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR004088" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR017705" /db_xref="InterPro:IPR022711" /db_xref="InterPro:IPR036612" /db_xref="SubtiList:BG13420" /db_xref="UniProtKB/Swiss-Prot:O31774" /translation="MTPIMMVLISILLILLGLVVGYFVRKTIAEAKIAGARGAAEQIL EDAKRDAEALKKEALLEAKDEIHKLRIDAEQEVRERRNELQKQENRLLQKEENLDRKH EGIDKREAMLEKKDHSLNERQQHIEEMESKVDEMIRMQQSELERISSLTRDEAKQIIL ERVENELSHDIAIMTKETENRAKEEADKKAKNILSLALQRCAADHVAETTVSVVNLPN DEMKGRIIGREGRNIRTLETLTGIDLIIDDTPEAVILSGFDPIRRETARIALDKLVQD GRIHPARIEEMVEKSRREVDDYIREMGEQTTFEVGVHGLHPDLIKILGRLKFRTSYGQ NVLKHSMEVAFLAGLMASELGEDAKLAKRAGLLHDIGKAIDHEVEGSHVEIGVELATK YKEHPVVINSIASHHGDEEPTSIIAVLVAAADALSAARPGARSETLENYIRRLEKLEE ISESYEGVEKSFAIQAGREVRIMVKPDSINDLEAHRLARDIRKRIEDELDYPGHIKVT VIRETRAVEYAK*" /label="rny CDS" gene 1646912..1648474 /gene="rny" /locus_tag="BSU_16960" /old_locus_tag="BSU16960" /label="rny gene" downshifts 1648451 /Source="Nicolas_upshifts" /id="D914" /incds=0 /nref=243 /ntot=268 /MaxReadThrough="5.32126" /MaxDrop="5.3789" /score="10.4712371" /energy="-9" /TU="U1357" /idTUdmin="U1357" /TUdmin="-1342" /isTUend="FALSE" /label="downshifts" CDS 1648543..1649337 /gene="pdeB" /locus_tag="BSU_16970" /old_locus_tag="BSU16970" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19376879, 21856853, 24163345, 26904951, 26906740" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19376879, 21856853, 24163345, 26904951, 26906740; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2'3' and 3'5' cyclic nucleotide monophosphates phosphodiesterase involved in biofilm formation" /protein_id="NP_389579.2" /db_xref="EnsemblGenomes-Gn:BSU16970" /db_xref="EnsemblGenomes-Tr:CAB13570" /db_xref="GOA:O31775" /db_xref="InterPro:IPR005235" /db_xref="InterPro:IPR029052" /db_xref="PDB:4B2O" /db_xref="SubtiList:BG13421" /db_xref="UniProtKB/Swiss-Prot:O31775" /translation="MRILFIGDVVGSPGRDMVKEYVPKLKTKYKPHFTIINGENAAHG KGLTEKIYHSLIQSGADAITMGNHTWDKKEIFDFIDDVPNLVRPANFPEGTPGKGITY VKANGKELAVINLQGRTFLPPLDDPFLKADELIAEAAKRTPYIFIDFHAEATSEKLAL GWYTDGRASAVVGTHTHVQTADNRILPKGTAYITDVGMTGPYDGILGMDRETIIKRFK TNLPVRFTVAEGKTTLSGVVIDIDDQTKKAVKIERILINDDHMFFE*" /label="pdeB CDS" gene 1648543..1649337 /gene="pdeB" /locus_tag="BSU_16970" /old_locus_tag="BSU16970" /label="pdeB gene" promotor_-35 1649092..1649097 /Source="Nicolas_upshift_promotors" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1649113..1649131 /Source="Nicolas_upshift_promotors" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="promotor_-10" upshifts 1649133 /Source="Nicolas_upshifts" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="upshifts" promotor_-35 1649381..1649386 /Source="Nicolas_upshift_promotors" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="promotor_-35" S_feature 1649397..1649536 /Source="Nicolas_S_feature" /locus_tag="new_1769795_1769934" /HighExp="T5.0H, LoTm, BT, B60, S8, M9-stat, S6, BC, B36, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="0.916, 0.91, 1" /TUlongSig="SigWXY, SigA, Sig-, SigA, SigA" /TUlongPSig="1, 1, 0.016, 0.998, 0.987" /label="S608" upshifts 1649397 /Source="Nicolas_upshifts" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="upshifts" promotor_-10 1649402..1649420 /Source="Nicolas_upshift_promotors" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="promotor_-10" upshifts complement(1649429) /Source="Nicolas_upshifts" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1649440..1649453) /Source="Nicolas_upshift_promotors" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1649462..1649466) /Source="Nicolas_upshift_promotors" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1649473) /Source="Nicolas_upshifts" /id="D915" /incds=0 /nref=5 /ntot=35 /MaxReadThrough="1.51152" /MaxDrop="3.63977" /score="3.80280375" /energy="-6.7" /TU="NA" /idTUdmin="U1366" /TUdmin=10274 /isTUend="FALSE" /label="downshifts" CDS 1649537..1649797 /gene="spoVS" /locus_tag="BSU_16980" /old_locus_tag="BSU16980" /function="16.3: Control" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7559352, 16428420, 18562273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7559352, 16428420, 18562273; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator required for dehydratation of the spore core and assembly of the coat (stage V sporulation)" /protein_id="NP_389580.1" /db_xref="EnsemblGenomes-Gn:BSU16980" /db_xref="EnsemblGenomes-Tr:CAB13571" /db_xref="GOA:P45693" /db_xref="InterPro:IPR007347" /db_xref="SubtiList:BG11245" /db_xref="UniProtKB/Swiss-Prot:P45693" /translation="MEILKVSAKSSPNSVAGALAGVLRERGAAEIQAIGAGALNQAVK AVAIARGFVAPSGVDLICIPAFTDIQIDGEERTAIKLIVEPR*" /label="spoVS CDS" gene 1649537..1649797 /gene="spoVS" /locus_tag="BSU_16980" /old_locus_tag="BSU16980" /label="spoVS gene" downshifts 1649749 /Source="Nicolas_upshifts" /id="D916" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="8.31914" /MaxDrop="4.27515" /score="5.18548432" /energy="-12.5" /TU="U1357,U1358,U1359" /idTUdmin="U1357" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts complement(1649781) /Source="Nicolas_upshifts" /id="D917" /incds=0 /nref=3 /ntot=15 /MaxReadThrough="1.16149" /MaxDrop="3.88837" /score="3.80280375" /energy="-6.7" /TU="NA" /idTUdmin="U1366" /TUdmin=9966 /isTUend="FALSE" /label="downshifts" downshifts 1649793 /Source="Nicolas_upshifts" /id="D918" /incds=0 /nref=171 /ntot=265 /MaxReadThrough="4.08266" /MaxDrop="5.124" /score="5.18548432" /energy="-12.5" /TU="U1358,U1359" /idTUdmin="U1357" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1649838..1650012 /Source="Nicolas_S_feature" /locus_tag="new_1770236_1770410" /HighExp="S6, S8, S7, M9-stat, Lbstat, BT, S5, T1.30H, T2.0H, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.916, 0.91" /TUlongSig="SigA, SigWXY" /TUlongPSig="1, 1" /label="S609" promotor_-35 1649996..1650003 /Source="Nicolas_upshift_promotors" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1650014 /Source="Nicolas_upshifts" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1650018..1650037 /Source="Nicolas_upshift_promotors" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1650063..1651106 /gene="tdh" /locus_tag="BSU_16990" /old_locus_tag="BSU16990" /EC_number="1.1.1.103" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8519804, 16817900, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine 3-dehydrogenase" /protein_id="NP_389581.1" /db_xref="EnsemblGenomes-Gn:BSU16990" /db_xref="EnsemblGenomes-Tr:CAB13572" /db_xref="GOA:O31776" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR004627" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12685" /db_xref="UniProtKB/Swiss-Prot:O31776" /translation="MQSGKMKALMKKDGAFGAVLTEVPIPEIDKHEVLIKVKAASICG TDVHIYNWDQWARQRIKTPYVFGHEFSGIVEGVGENVSSVKVGEYVSAETHIVCGECV PCLTGKSHVCTNTAIIGVDTAGCFAEYVKVPADNIWRNPADMDPSIASIQEPLGNAVH TVLESQPAGGTTAVIGCGPIGLMAVAVAKAAGASQVIAIDKNEYRLRLAKQMGATCTV SIEKEDPLKIVSALTSGEGADLVCEMSGHPSAIAQGLAMAANGGRFHILSLPEHPVTI DLTNKVVFKGLTIQGITGRKMFSTWRQVSQLISSNMIDLAPVITHQFPLEEFEKGFEL MRSGQCGKVILIP*" /label="tdh CDS" gene 1650063..1651106 /gene="tdh" /locus_tag="BSU_16990" /old_locus_tag="BSU16990" /label="tdh gene" CDS 1651119..1652297 /gene="kbl" /locus_tag="BSU_17000" /old_locus_tag="BSU17000" /EC_number="2.3.1.29" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17146529, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-amino-3-ketobutyrate CoA ligase (glycine acetyl transferase)" /protein_id="NP_389582.1" /db_xref="EnsemblGenomes-Gn:BSU17000" /db_xref="EnsemblGenomes-Tr:CAB13573" /db_xref="GOA:O31777" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004723" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR010962" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12610" /db_xref="UniProtKB/Swiss-Prot:O31777" /translation="MTKEFEFLKAELNSMKENHTWQDIKQLESMQGPSVTVNHQKVIQ LSSNNYLGFTSHPRLINAAQEAVQQYGAGTGSVRTIAGTFTMHQELEKKLAAFKKTEA ALVFQSGFTTNQGVLSSILSKEDIVISDELNHASIIDGIRLTKADKKVYQHVNMSDLE RVLRKSMNYRMRLIVTDGVFSMDGNIAPLPDIVELAEKYDAFVMVDDAHASGVLGENG RGTVNHFGLDGRVHIQVGTLSKAIGVLGGYAAGSKVLIDYLRHKGRPFLFSTSHPPAV TAACMEAIDVLLEEPEHMERLWENTAYFKAMLVKMGLTLTKSETPILPILIGDEGVAK QFSDQLLSRGVFAQSIVFPTVAKGKARIRTIITAEHTKDELDQALDVIEKTAKELQLL *" /label="kbl CDS" gene 1651119..1652297 /gene="kbl" /locus_tag="BSU_17000" /old_locus_tag="BSU17000" /label="kbl gene" downshifts 1652279 /Source="Nicolas_upshifts" /id="D919" /incds=0 /nref=3 /ntot=25 /MaxReadThrough="5.75732" /MaxDrop="3.4918" /score="4.73069387" /energy="-12.5" /TU="U1361" /idTUdmin="U1359" /TUdmin=1936 /isTUend="FALSE" /label="downshifts" promotor_-35 1652377..1652380 /Source="Nicolas_upshift_promotors" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1652389 /Source="Nicolas_upshifts" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1652395..1652414 /Source="Nicolas_upshift_promotors" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1652445..1653974 /gene="miaB" /locus_tag="BSU_17010" /old_locus_tag="BSU17010" /EC_number="2.8.4.3" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15175311, 18307109, 20472640, 20584901, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15175311, 18307109, 20472640, 20584901, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme for ms(2)i(6)A formation for tRNA modification" /protein_id="NP_389583.1" /db_xref="EnsemblGenomes-Gn:BSU17010" /db_xref="EnsemblGenomes-Tr:CAB13574" /db_xref="GOA:O31778" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR005839" /db_xref="InterPro:IPR006463" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013848" /db_xref="InterPro:IPR020612" /db_xref="InterPro:IPR023404" /db_xref="SubtiList:BG13418" /db_xref="UniProtKB/Swiss-Prot:O31778" /translation="MNEKQKLESGQVHPSDKKSEKDYSKYFEAVYIPPSLKDAKKRGK EAVTYHNDFKISEQFKGLGDGRKFYIRTYGCQMNEHDTEVMAGIFMALGYEATNSVDD ANVILLNTCAIRENAENKVFGELGHLKALKKNNPDLILGVCGCMSQEESVVNRILKKH PFVDMIFGTHNIHRLPELLSEAYLSKEMVVEVWSKEGDVIENLPKVRNGKIKGWVNIM YGCDKFCTYCIVPYTRGKERSRRPEDIIQEVRRLASEGYKEITLLGQNVNAYGKDFED MTYGLGDLMDELRKIDIPRIRFTTSHPRDFDDRLIEVLAKGGNLLDHIHLPVQSGSSE VLKLMARKYDRERYMELVRKIKEAMPNASLTTDIIVGFPNETDEQFEETLSLYREVEF DSAYTFIYSPREGTPAAKMKDNVPMRVKKERLQRLNALVNEISAKKMKEYEGKVVEVL VEGESKNNPDILAGYTEKSKLVNFKGPKEAIGKIVRVKIQQAKTWSLDGEMVGEAIEV K*" /label="miaB CDS" gene 1652445..1653974 /gene="miaB" /locus_tag="BSU_17010" /old_locus_tag="BSU17010" /label="miaB gene" CDS 1653976..1654407 /gene="ricA" /locus_tag="BSU_17020" /old_locus_tag="BSU17020" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10712692, 15175311, 15661000, 22720735, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10712692, 15175311, 15661000, 22720735, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="master regulator for biofilm formation via regulation of RNase Y (RicAFT complex / FAD / two [4Fe-4S]2+)" /protein_id="NP_389584.1" /db_xref="EnsemblGenomes-Gn:BSU17020" /db_xref="EnsemblGenomes-Tr:CAB13575" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR016783" /db_xref="InterPro:IPR023378" /db_xref="PDB:2PIH" /db_xref="SubtiList:BG13417" /db_xref="UniProtKB/Swiss-Prot:O31779" /translation="MTLYSKKDIVQQARNLAKMISETEEVDFFKRAEAQINENDKVST IVNQIKALQKQAVNLKHYEKHEALKQVEAKIDALQEELEEIPVIQEFRDSQMEVNDLL QLVAHTISNQVTNEIITSTGGDLLKGETGSKVKHSNNSCSL*" /label="ricA CDS" gene 1653976..1654407 /gene="ricA" /locus_tag="BSU_17020" /old_locus_tag="BSU17020" /label="ricA gene" downshifts 1654390 /Source="Nicolas_upshifts" /id="D920" /incds=0 /nref=255 /ntot=267 /MaxReadThrough="0.9572" /MaxDrop="7.73043" /score="21.1260722" /energy="-10.3" /TU="NA" /idTUdmin="U1361" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 1654538..1654543 /Source="Nicolas_upshift_promotors" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1654559..1654577 /Source="Nicolas_upshift_promotors" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1654567..1654668 /Source="Nicolas_S_feature" /locus_tag="new_1774965_1775066" /HighExp="S3, S5, S8, S4, S6, S7, B36, BT, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S610" upshifts 1654567 /Source="Nicolas_upshifts" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="upshifts" CDS 1654669..1655214 /gene="cotE" /locus_tag="BSU_17030" /old_locus_tag="BSU17030" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 14563859, 14973022, 17172339, 20023017, 22773792, 25259857, 26821119, 27320701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 14563859, 14973022, 17172339, 20023017, 22773792, 25259857, 26821119, 27320701; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="morphogenic spore protein" /protein_id="NP_389585.1" /db_xref="EnsemblGenomes-Gn:BSU17030" /db_xref="EnsemblGenomes-Tr:CAB13576" /db_xref="GOA:P14016" /db_xref="InterPro:IPR018901" /db_xref="SubtiList:BG10494" /db_xref="UniProtKB/Swiss-Prot:P14016" /translation="MSEYREIITKAVVAKGRKFTQCTNTISPEKKPSSILGGWIINHK YDAEKIGKTVEIEGYYDINVWYSYADNTKTEVVTERVKYVDVIKLRYRDNNYLDDEHE VIAKVLQQPNCLEVTISPNGNKIVVQAEREFLAEVVGETKVVVEVNPDWEEDDEEDWE DELDEELEDINPEFLVGDPEE*" /label="cotE CDS" gene 1654669..1655214 /gene="cotE" /locus_tag="BSU_17030" /old_locus_tag="BSU17030" /label="cotE gene" downshifts 1655208 /Source="Nicolas_upshifts" /id="D921" /incds=0 /nref=64 /ntot=97 /MaxReadThrough="4.37388" /MaxDrop="8.23792" /score="10.7927556" /energy="-12.6" /TU="U1363" /idTUdmin="U1363" /TUdmin="-745" /isTUend="FALSE" /label="downshifts" downshifts complement(1655215) /Source="Nicolas_upshifts" /id="D922" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="4.21458" /MaxDrop="3.44208" /score="12.3953461" /energy="-11.4" /TU="NA" /idTUdmin="U1366" /TUdmin=4532 /isTUend="FALSE" /label="downshifts" promotor_-35 1655272..1655275 /Source="Nicolas_upshift_promotors" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1655290..1655309 /Source="Nicolas_upshift_promotors" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1655294 /Source="Nicolas_upshifts" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="upshifts" CDS 1655347..1657923 /gene="mutS" /locus_tag="BSU_17040" /old_locus_tag="BSU17040" /function="16.5: Explore" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15375129, 16269814, 23998896, 26343983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15375129, 16269814, 23998896, 26343983; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA mismatch repair recognition factor" /protein_id="NP_389586.2" /db_xref="EnsemblGenomes-Gn:BSU17040" /db_xref="EnsemblGenomes-Tr:CAB13577" /db_xref="GOA:P49849" /db_xref="InterPro:IPR000432" /db_xref="InterPro:IPR005748" /db_xref="InterPro:IPR007695" /db_xref="InterPro:IPR007696" /db_xref="InterPro:IPR007860" /db_xref="InterPro:IPR007861" /db_xref="InterPro:IPR016151" /db_xref="InterPro:IPR017261" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036187" /db_xref="InterPro:IPR036678" /db_xref="SubtiList:BG11403" /db_xref="UniProtKB/Swiss-Prot:P49849" /translation="MAGYTPMIQQYLKIKAEHQDAFLFFRLGDFYEMFFEDAKKASQE LEITLTSRDGGAAEKIPMCGVPYHSASAYIEQLIKKGYKVAICEQTEDPKAAKGVVKR EVVQLITPGTVMDGKGIHESENNFIASVSACSNGYGLALSDLTTGENLAVLIERLEDV ISEIYSVGAREIVVSGSLDADTVAQLRERCGATISIEDGETDEHVTIIEHLNNEDITK TFLRLYTYLKRTQKRSLDHLQPVQVYELEEAMKIDLYSKRNLELTETIRSKNKKGSLL WLLDETKTAMGGRLLKQWIDRPLIRVNQIEERQEMVETLMSHFFEREDLRERLKEVYD LERLAGRVAFGNVNARDLIQLKESLKQVPGIKQLVASLAHDKAKERAKRIDPCGDVLE LLEEALYENPPLSVKEGNLIKDGYNQKLDEYRDASRNGKDWIARLEQQEREYTGIRSL KVGFNKVFGYYIEVTKANLHLLEEGRYERKQTLTNAERYITPELKEKEALILEAENNI CELEYELFTELREKVKQYIPRLQQLAKQMSELDALQCFATISENRHYTKPEFSKDEVE VIEGRHPVVEKVMDSQEYVPNNCMMGDNRQMLLITGPNMSGKSTYMRQIALISIMAQI GCFVPAKKAVLPIFDQIFTRIGAADDLISGQSTFMVEMLEAKNAIVNATKNSLILFDE IGRGTSTYDGMALAQAIIEYVHDHIGAKTLFSTHYHELTVLEDKLPQLKNVHVRAEEY NGTVVFLHQIKEGAADKSYGIHVAQLAELPGDLIARAQDILKELEHSGNKPEVPVQKP QVKEEPAQLSFFDEAEKPAETPKLSKKEKQVIDAFKSLNILDMTPLEAMNEMYKLQKK LH*" /label="mutS CDS" gene 1655347..1657923 /gene="mutS" /locus_tag="BSU_17040" /old_locus_tag="BSU17040" /label="mutS gene" CDS 1657939..1659822 /gene="mutL" /locus_tag="BSU_17050" /old_locus_tag="BSU17050" /function="16.8: Protect" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15375129, 22843852, 26343983, 26384423, 27369079" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15375129, 22843852, 26343983, 26384423, 27369079; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA mismatch repair endonuclease" /protein_id="NP_389587.1" /db_xref="EnsemblGenomes-Gn:BSU17050" /db_xref="EnsemblGenomes-Tr:CAB13578" /db_xref="GOA:P49850" /db_xref="InterPro:IPR002099" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR013507" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR014762" /db_xref="InterPro:IPR014790" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020667" /db_xref="InterPro:IPR036890" /db_xref="InterPro:IPR037198" /db_xref="PDB:3GAB" /db_xref="PDB:3KDG" /db_xref="PDB:3KDK" /db_xref="SubtiList:BG11402" /db_xref="UniProtKB/Swiss-Prot:P49850" /translation="MAKVIQLSDELSNKIAAGEVVERPASVVKELVENAIDADSTVIE IDIEEAGLASIRVLDNGEGMENEDCKRAFRRHATSKIKDENDLFRVRTLGFRGEALPS IASVSHLEITTSTGEGAGTKLVLQGGNIISESRSSSRKGTEIVVSNLFFNTPARLKYM KTVHTELGNITDVVNRIALAHPEVSIRLRHHGKNLLQTNGNGDVRHVLAAIYGTAVAK KMLPLHVSSLDFEVKGYIALPEITRASRNYMSSVVNGRYIKNFPLVKAVHEGYHTLLP IGRHPITFIEITMDPILVDVNVHPSKLEVRLSKETELHDLIRDGIKDVFKQQQLIPSA QVPKKSAPAIKNEQQFITFDEKPPEKKVPEKSTAPSYSPMKLSSVVKEPVDAEEKLPP LQFDAPPIVDQEQTLEVSDVSAEQPETFEQECHEEQPQPASDRVPIMYPIGQMHGTYI LAQNENGLYIIDQHAAQERIKYEYFREKVGEVEPEVQEMIVPLTFHYSTNEALIIEQH KQELESVGVFLESFGSNSYIVRCHPAWFPKGEEAELIEEIIQQVLDSKNIDIKKLREE AAIMMSCKGSIKANRHLRNDEIKALLDDLRSTSDPFTCPHGRPIIIHHSTYEMEKMFK RVM*" /label="mutL CDS" gene 1657939..1659822 /gene="mutL" /locus_tag="BSU_17050" /old_locus_tag="BSU17050" /label="mutL gene" S_feature complement(1659725..1660219) /Source="Nicolas_S_feature" /locus_tag="new_1780123_1780617_c" /HighExp="M9-stat, LBGstat, LPhT, T2.0H, Lbstat, C30, T2.30H, M0t90, T1.30H, HiOs" /AntisenseName="mutL" /AntisenseCor="0.27126904061692803" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S611" downshifts 1659737 /Source="Nicolas_upshifts" /id="D923" /incds=1 /nref=216 /ntot=257 /MaxReadThrough="2.0064" /MaxDrop="5.37369" /score="33.4967163" /energy="-18.6" /TU="NA" /idTUdmin="U1364" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1659747) /Source="Nicolas_upshifts" /id="D924" /incds=1 /nref=3 /ntot=100 /MaxReadThrough="1.93338" /MaxDrop="2.7192" /score="27.1353816" /energy="-13.5" /TU="NA" /idTUdmin="U1366" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1659969..1659976 /Source="Nicolas_upshift_promotors" /id="U1365" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=478 /SigmaFactorBS="tcatggttcctccgtataacaaaatttcCATTTACAggcaat tgggattaATGTATATTTTGGGTGAGGGggtggaaacatatggcatgtggtccgaaga t" /listShort="S612" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1659991..1660010 /Source="Nicolas_upshift_promotors" /id="U1365" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=478 /SigmaFactorBS="tcatggttcctccgtataacaaaatttcCATTTACAggcaat tgggattaATGTATATTTTGGGTGAGGGggtggaaacatatggcatgtggtccgaaga t" /listShort="S612" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1660001..1660134 /Source="Nicolas_S_feature" /locus_tag="new_1780399_1780532" /HighExp="LoTm, T0.30H, T1.30H, M9-stat, T3.0H, BC, T1.0H, B60, B36, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99494800000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S612" upshifts 1660001 /Source="Nicolas_upshifts" /id="U1365" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=478 /SigmaFactorBS="tcatggttcctccgtataacaaaatttcCATTTACAggcaat tgggattaATGTATATTTTGGGTGAGGGggtggaaacatatggcatgtggtccgaaga t" /listShort="S612" /GFF_Attribute="listLong" /label="upshifts" misc_RNA complement(1660006..1660156) /gene="surX" /locus_tag="BSU_misc_RNA_89" /product="small untranslated RNA of unknown function" /note="Evidence 5: Unknown function; PubMedId : 20525796, 23155385" /label="surX RNA" gene complement(1660006..1660156) /gene="surX" /locus_tag="BSU_misc_RNA_89" /label="surX gene" downshifts 1660091 /Source="Nicolas_upshifts" /id="D925" /incds=0 /nref=19 /ntot=136 /MaxReadThrough="3.45962" /MaxDrop="4.12444" /score="29.4045648" /energy="-15.3" /TU="U1365" /idTUdmin="U1364" /TUdmin=354 /isTUend="FALSE" /label="downshifts" CDS complement(1660220..1660675) /gene="ymzD" /locus_tag="BSU_17060" /old_locus_tag="BSU17060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="YP_054578.1" /db_xref="EnsemblGenomes-Gn:BSU17060" /db_xref="EnsemblGenomes-Tr:CAE01453" /db_xref="GOA:Q7WY71" /db_xref="InterPro:IPR025912" /db_xref="SubtiList:BG14188" /db_xref="UniProtKB/Swiss-Prot:Q7WY71" /translation="MNQKEQNEHSKDFNLRSKLIGIVSITFIAAIALAVIFGGFFFGM KGLFSILGITYASNQTLALFILACFAVGLIIDPLTKIISIILAKSLSLKKTALFAFIL YFISNLITICFADYFMQSIYIPDVLLVVISAFMAIIELAFDNQPNREAA*" /label="ymzD CDS" gene complement(1660220..1660675) /gene="ymzD" /locus_tag="BSU_17060" /old_locus_tag="BSU17060" /label="ymzD gene" S_feature complement(1660676..1660767) /Source="Nicolas_S_feature" /locus_tag="new_1781074_1781165_c" /HighExp="LBGstat, M9-stat, T1.0H, T1.30H, T2.0H, M0t90, MG 150, LPhT, T3.0H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S613" promotor_-10 complement(1660755..1660774) /Source="Nicolas_upshift_promotors" /id="U1366" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.537462537462537" /psig="0.999000999001" /xcortree=3231 /SigmaFactorBS="tgatgaaaaaggcccttccccagtggaaagggcCTTTtttgg ttttgttaaaaTATGCTATACTATTTTCGTCagaaaacagacttatagatattttggg c" /listShort="S613, ymzD, S611" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1660767) /Source="Nicolas_upshifts" /id="U1366" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.537462537462537" /psig="0.999000999001" /xcortree=3231 /SigmaFactorBS="tgatgaaaaaggcccttccccagtggaaagggcCTTTtttgg ttttgttaaaaTATGCTATACTATTTTCGTCagaaaacagacttatagatattttggg c" /listShort="S613, ymzD, S611" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1660791..1660794) /Source="Nicolas_upshift_promotors" /id="U1366" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.537462537462537" /psig="0.999000999001" /xcortree=3231 /SigmaFactorBS="tgatgaaaaaggcccttccccagtggaaagggcCTTTtttgg ttttgttaaaaTATGCTATACTATTTTCGTCagaaaacagacttatagatattttggg c" /listShort="S613, ymzD, S611" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1660830..1661387) /gene="ymcC" /locus_tag="BSU_17070" /old_locus_tag="BSU17070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389588.1" /db_xref="EnsemblGenomes-Gn:BSU17070" /db_xref="EnsemblGenomes-Tr:CAB13579" /db_xref="GOA:O31780" /db_xref="SubtiList:BG13419" /db_xref="UniProtKB/Swiss-Prot:O31780" /translation="MNGIAWMIVFCEIAFWVVIVLGLAVRYVFKRHTLGLLFLALTPV IDLILLAATGVDLYRGASATAAHGIAAVYIGISIAYGKQMIQWADEKFQYYVTKKGTK PLKRFGMDHAKHGAKGWLRHVLAYLIGAGLLAGMIYFINDSSRTEALSGILKLWTVII GIDFLITASYFIWPKKEKASANLRS*" /label="ymcC CDS" gene complement(1660830..1661387) /gene="ymcC" /locus_tag="BSU_17070" /old_locus_tag="BSU17070" /label="ymcC gene" SCAR 1661478..1661479 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs08" downshifts complement(1661530) /Source="Nicolas_upshifts" /id="D929" /incds=0 /nref=24 /ntot=184 /MaxReadThrough="3.69744" /MaxDrop="5.18486" /score="-0.71313204" /energy="-20.1" /TU="U1374" /idTUdmin="U1375" /TUdmin=28 /isTUend="FALSE" /label="downshifts" CDS complement(1661536..1661892) /gene="ymzB" /locus_tag="BSU_17240" /old_locus_tag="BSU17240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11544224, 15805528, 20817675" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function involved in ethanol resistance" /protein_id="NP_389606.3" /db_xref="EnsemblGenomes-Gn:BSU17240" /db_xref="EnsemblGenomes-Tr:CAB13608" /db_xref="SubtiList:BG13435" /db_xref="UniProtKB/Swiss-Prot:O31786" /translation="MAHTNTQLSQWLESKVGQTLDIRKGELTHDEEISDLDQIVLHLQ KVAIRSTNHPDDYVAKEELVLEGEGTTFTEDGNVPLPQNAYEIPLLGELHIHQENEGL KVVTDRAVYTIDIQHS*" /label="ymzB CDS" gene complement(1661536..1661892) /gene="ymzB" /locus_tag="BSU_17240" /old_locus_tag="BSU17240" /label="ymzB gene" misc_feature complement(1661952..1661965) /Source="Nicolas_upshift_promotors" /id="U1374" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.511488511488511" /psig="0.121878121878122" /xcortree=731 /SigmaFactorBS="ccgtacgctatatcaaggcactcaacagcgaactgtttcata cataaagagtGGGGCGGCTCTTTCccgtgtaaaagatgcagcaattgggaatagtatc g" /listShort="ymzB, S618, pksS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1661957) /Source="Nicolas_upshifts" /id="U1374" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.511488511488511" /psig="0.121878121878122" /xcortree=731 /SigmaFactorBS="ccgtacgctatatcaaggcactcaacagcgaactgtttcata cataaagagtGGGGCGGCTCTTTCccgtgtaaaagatgcagcaattgggaatagtatc g" /listShort="ymzB, S618, pksS" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1661971..1662795) /gene="ymaE" /locus_tag="BSU_17250" /old_locus_tag="BSU17250" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20817675; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389607.2" /db_xref="EnsemblGenomes-Gn:BSU17250" /db_xref="EnsemblGenomes-Tr:CAB13609" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13413" /db_xref="UniProtKB/Swiss-Prot:O31787" /translation="MPYYICNTCGVQHAQTVDPPNSCLICEDERQYIHPDGQTWTTLE DMREKGNLQNILKKEEEHLYSIKTEPEFAIGQTAHLIQHKGFNVLWDCMTYLDQKTID QINELGGIQAIALSHPHYYSTQVEWAEAFQAPIYIHEDDKEWVTRPSNHIHFWSGETL NMKPGLDLYRLGGHFKGGAVLHWSKGNEGKGCLLTGDIITVAADRNWVSFMYSYPNLI PLPASKVEEIAAKVKPLQFNRLYNAFSKVVKENADESVQRSAVRYIKALNSELFHT*" /label="ymaE CDS" gene complement(1661971..1662795) /gene="ymaE" /locus_tag="BSU_17250" /old_locus_tag="BSU17250" /label="ymaE gene" promotor_-10 complement(1662817..1662836) /Source="Nicolas_upshift_promotors" /id="U1375" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.88011988011988" /psig="0.992007992007992" /xcortree=2946 /SigmaFactorBS="gccggcaattctctctcagcagaactgccggttttttcgTTT GAATattcataatcaTAAGGTAAAATAATGGAAAAtagatgaaggaagtgaagaaagt g" /listShort="ymaE, ymzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1662833) /Source="Nicolas_upshifts" /id="U1375" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.88011988011988" /psig="0.992007992007992" /xcortree=2946 /SigmaFactorBS="gccggcaattctctctcagcagaactgccggttttttcgTTT GAATattcataatcaTAAGGTAAAATAATGGAAAAtagatgaaggaagtgaagaaagt g" /listShort="ymaE, ymzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1662848..1662854) /Source="Nicolas_upshift_promotors" /id="U1375" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.88011988011988" /psig="0.992007992007992" /xcortree=2946 /SigmaFactorBS="gccggcaattctctctcagcagaactgccggttttttcgTTT GAATattcataatcaTAAGGTAAAATAATGGAAAAtagatgaaggaagtgaagaaagt g" /listShort="ymaE, ymzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1662906..1664234) /gene="aprX" /locus_tag="BSU_17260" /old_locus_tag="BSU17260" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10589719, 16267290, 17884659, 28693413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10589719, 16267290, 17884659, 28693413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkaline serine protease" /protein_id="NP_389608.1" /db_xref="EnsemblGenomes-Gn:BSU17260" /db_xref="EnsemblGenomes-Tr:CAB13610" /db_xref="GOA:O31788" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR036852" /db_xref="SubtiList:BG12567" /db_xref="UniProtKB/Swiss-Prot:O31788" /translation="MFGYSMVQMVRANAHKLDWPLRETVLQLYKPFKWTPCFLHKFFE TKLQNRKKMSVIIEFEEGCHETGFQMAGEVLQKEKRSKLKSRFNKINCCSAEVTPSAL HSLLSECSNIRKVYLNREVKALLDTATEASHAKEVVRNGQTLTGKGVTVAVVDTGIYP HPDLEGRIIGFADMVNQKTEPYDDNGHGTHCAGDVASSGASSSGQYRGPAPEANLIGV KVLNKQGSGTLADIIEGVEWCIQYNEDNPDEPIDIMSMSLGGDALRYDHEQEDPLVRA VEEAWSAGIVVCVAAGNSGPDSQTIASPGVSEKVITVGALDDNNTASSDDDTVASFSS RGPTVYGKEKPDILAPGVNIISLRSPNSYIDKLQKSSRVGSQYFTMSGTSMATPICAG IAALILQQNPDLTPDEVKELLKNGTDKWKDEDPNIYGAGAVNAENSVPGQ*" /label="aprX CDS" gene complement(1662906..1664234) /gene="aprX" /locus_tag="BSU_17260" /old_locus_tag="BSU17260" /label="aprX gene" downshifts complement(1662913) /Source="Nicolas_upshifts" /id="D930" /incds=0 /nref=13 /ntot=21 /MaxReadThrough="2.43809" /MaxDrop="5.8915" /score="10.5332562" /energy="-13" /TU="NA" /idTUdmin="U1376" /TUdmin=8 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1664257..1664276) /Source="Nicolas_upshift_promotors" /id="U1376" /multdbtbs="SigA" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1433 /SigmaFactorBS="aaaacaaactcttgtctgtctcttacagaggacaaacaAACT TACCAaacctatcatctgTTCATAGAGTATACAGAGAAccttataataggaggaaaat a" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1664276) /Source="Nicolas_upshifts" /id="U1376" /multdbtbs="SigA" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1433 /SigmaFactorBS="aaaacaaactcttgtctgtctcttacagaggacaaacaAACT TACCAaacctatcatctgTTCATAGAGTATACAGAGAAccttataataggaggaaaat a" /listShort="aprX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1664290..1664298) /Source="Nicolas_upshift_promotors" /id="U1376" /multdbtbs="SigA" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1433 /SigmaFactorBS="aaaacaaactcttgtctgtctcttacagaggacaaacaAACT TACCAaacctatcatctgTTCATAGAGTATACAGAGAAccttataataggaggaaaat a" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1664391..1664398 /Source="Nicolas_upshift_promotors" /id="U1378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.806193806193806" /psig="0.999000999001" /xcortree=1507 /SigmaFactorBS="gatagattcagaagctgaggaaatcattgggGATTGAAAaag aacgtttgttcgTATTATAATGTGATCATATCaaactgggaaggggagagcaaccgta t" /listShort="ymzE, ymzE, S619, ymaC, ymaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1664406..1664425) /Source="Nicolas_upshift_promotors" /id="U1377" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.753246753246753" /psig="0.999000999001" /xcortree=1500 /SigmaFactorBS="ggtgcaagtagaaattcatacggttgctctccCCTTCCCAgt ttgatatgatCACATTATAATACGAACAAAcgttctttttcaatccccaatgatttcc t" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1664414..1664433 /Source="Nicolas_upshift_promotors" /id="U1378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.806193806193806" /psig="0.999000999001" /xcortree=1507 /SigmaFactorBS="gatagattcagaagctgaggaaatcattgggGATTGAAAaag aacgtttgttcgTATTATAATGTGATCATATCaaactgggaaggggagagcaaccgta t" /listShort="ymzE, ymzE, S619, ymaC, ymaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1664417) /Source="Nicolas_upshifts" /id="U1377" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.753246753246753" /psig="0.999000999001" /xcortree=1500 /SigmaFactorBS="ggtgcaagtagaaattcatacggttgctctccCCTTCCCAgt ttgatatgatCACATTATAATACGAACAAAcgttctttttcaatccccaatgatttcc t" /listShort="aprX" /GFF_Attribute="listLong" /label="upshifts" upshifts 1664420 /Source="Nicolas_upshifts" /id="U1378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.806193806193806" /psig="0.999000999001" /xcortree=1507 /SigmaFactorBS="gatagattcagaagctgaggaaatcattgggGATTGAAAaag aacgtttgttcgTATTATAATGTGATCATATCaaactgggaaggggagagcaaccgta t" /listShort="ymzE, ymzE, S619, ymaC, ymaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1664438..1664445) /Source="Nicolas_upshift_promotors" /id="U1377" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.753246753246753" /psig="0.999000999001" /xcortree=1500 /SigmaFactorBS="ggtgcaagtagaaattcatacggttgctctccCCTTCCCAgt ttgatatgatCACATTATAATACGAACAAAcgttctttttcaatccccaatgatttcc t" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1664459..1664536 /gene="ymzEn" /locus_tag="BSU_17266" /old_locus_tag="BSU17266" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; N-terminal part of YmzE" /translation="MNFYLHRSLESQMPISIIYEERRND*" /label="ymzEn CDS" gene 1664459..1664536 /gene="ymzEn" /locus_tag="BSU_17266" /old_locus_tag="BSU17266" /pseudo /label="ymzEn gene" downshifts complement(1664461) /Source="Nicolas_upshifts" /id="D931" /incds=0 /nref=4 /ntot=7 /MaxReadThrough="1.51659" /MaxDrop="5.37668" /score="10.5332562" /energy="-13" /TU="NA" /idTUdmin="U1377" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS 1664514..1664690 /gene="ymzEc" /locus_tag="BSU_17267" /old_locus_tag="BSU17267" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; C-terminal part of YmzE" /db_xref="PSEUDO:CAX52622.1" /translation="MKKDGTISKRTIIVRQKSKTKIKAFCFSKQQIRTFLLDSILSCD FVRTNKQNLYSAGR*" /label="ymzEc CDS" gene 1664514..1664690 /gene="ymzEc" /locus_tag="BSU_17267" /old_locus_tag="BSU17267" /pseudo /label="ymzEc gene" downshifts 1664671 /Source="Nicolas_upshifts" /id="D932" /incds=0 /nref=42 /ntot=207 /MaxReadThrough="4.03151" /MaxDrop="6.55778" /score="-0.929304655" /energy="-5.5" /TU="U1378" /idTUdmin="U1378" /TUdmin="-1496" /isTUend="FALSE" /label="downshifts" S_feature 1664716..1664904 /Source="Nicolas_S_feature" /locus_tag="new_1863194_1863382" /HighExp="H2O2, M40t90, C90, M40t45, C30, S8, HiOs, G135, T-4.40H, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S619" misc_feature 1664899..1664918 /Source="Nicolas_upshift_promotors" /id="U1379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.44955044955045" /psig=1 /xcortree=2371 /SigmaFactorBS="atcaattgattttttgaaaccgggaactttttcactgatgat attgtgtatacAATGGTAAGATAAAACCTATtggctaaacctcatataatgaaccgcg c" /listShort="ymaC, ymaD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1664906 /Source="Nicolas_upshifts" /id="U1379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.44955044955045" /psig=1 /xcortree=2371 /SigmaFactorBS="atcaattgattttttgaaaccgggaactttttcactgatgat attgtgtatacAATGGTAAGATAAAACCTATtggctaaacctcatataatgaaccgcg c" /listShort="ymaC, ymaD" /GFF_Attribute="listLong" /label="upshifts" CDS 1664970..1665677 /gene="pghC" /locus_tag="BSU_17270" /old_locus_tag="BSU17270" /EC_number="3.4.19.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 16267290, 26158264; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="gamma-polyglutamate hydrolase (phage origin)" /protein_id="NP_389609.1" /db_xref="EnsemblGenomes-Gn:BSU17270" /db_xref="EnsemblGenomes-Tr:CAB13611" /db_xref="GOA:O31789" /db_xref="InterPro:IPR008585" /db_xref="SubtiList:BG13411" /db_xref="UniProtKB/Swiss-Prot:O31789" /translation="MRRFLLNVILVLAIVLFLRYVHYSLEPEPSNQPDTYSNFSSLAE NESPADYDISYNEKKGSKVLIMSPHGGRIEGGVSELVRYFNNEYSTYLFEGLKSHDNQ TLHITSTNFDEPLAKKKIKEHQYVVAFHGYKGENKNTLVGGTDRKRAKMIVRALERRG FSAELASSKSGLAGLNAENINNQGETGLSIQLEISREQREAFFDDFYYKNRKYTKNSE FYAYVSAIKGVLEKEYS*" /label="pghC CDS" gene 1664970..1665677 /gene="pghC" /locus_tag="BSU_17270" /old_locus_tag="BSU17270" /label="pghC gene" promotor_-35 1665688..1665694 /Source="Nicolas_upshift_promotors" /id="U1380" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.843156843156843" /xcortree=1826 /SigmaFactorBS="gtgtcctggaaaaagagtattcgtaacaagcagatcAGAAGA CaaaataagagaagATCAGTAGACTGAAATAGGAtaaaaaaggaggcaaaacaatggc a" /listShort="ymaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1665708..1665727 /Source="Nicolas_upshift_promotors" /id="U1380" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.843156843156843" /xcortree=1826 /SigmaFactorBS="gtgtcctggaaaaagagtattcgtaacaagcagatcAGAAGA CaaaataagagaagATCAGTAGACTGAAATAGGAtaaaaaaggaggcaaaacaatggc a" /listShort="ymaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1665712 /Source="Nicolas_upshifts" /id="U1380" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.843156843156843" /xcortree=1826 /SigmaFactorBS="gtgtcctggaaaaagagtattcgtaacaagcagatcAGAAGA CaaaataagagaagATCAGTAGACTGAAATAGGAtaaaaaaggaggcaaaacaatggc a" /listShort="ymaD" /GFF_Attribute="listLong" /label="upshifts" CDS 1665747..1666199 /gene="ymaD" /locus_tag="BSU_17280" /old_locus_tag="BSU17280" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290, 22904090, 25649915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peroxiredoxin-related protein" /protein_id="NP_389610.1" /db_xref="EnsemblGenomes-Gn:BSU17280" /db_xref="EnsemblGenomes-Tr:CAB13612" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019905" /db_xref="InterPro:IPR036102" /db_xref="SubtiList:BG13412" /db_xref="UniProtKB/Swiss-Prot:O31790" /translation="MADHHFYLKANWPGNRNDVGTIESGNLITSISIPKEMDGPGEGT NPDEMLLGAAATCYIITLAAMMERSGLEKEDLQMESEGIVNVTKGVFTYKKIIHRPSV VLKHDASQDDVALAHKLCKKAESSCMISRAIQGNVELQLEASVKLGGE*" /label="ymaD CDS" gene 1665747..1666199 /gene="ymaD" /locus_tag="BSU_17280" /old_locus_tag="BSU17280" /label="ymaD gene" downshifts 1666187 /Source="Nicolas_upshifts" /id="D933" /incds=0 /nref=44 /ntot=182 /MaxReadThrough="1.35366" /MaxDrop="6.07534" /score="17.0193804" /energy="-12.1" /TU="NA" /idTUdmin="U1379" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1666213..1666566) /gene="ebrB" /locus_tag="BSU_17290" /old_locus_tag="BSU17290" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735876, 15849754, 16750162, 16850406, 18024586, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735876, 15849754, 16750162, 16850406, 18024586, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small toxic metabolite efflux transporter subunit" /protein_id="NP_389611.1" /db_xref="EnsemblGenomes-Gn:BSU17290" /db_xref="EnsemblGenomes-Tr:CAB13613" /db_xref="GOA:P0CW82" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12586" /db_xref="UniProtKB/Swiss-Prot:P0CW82" /translation="MRGLLYLALAIVSEVFGSTMLKLSEGFTQAWPIAGVIVGFLSAF TFLSFSLKTIDLSSAYATWSGVGTALTAIVGFLLFGETISLKGVFGLTLVIAGVVVLN QSKAHAEDKKQTACE*" /label="ebrB CDS" gene complement(1666213..1666566) /gene="ebrB" /locus_tag="BSU_17290" /old_locus_tag="BSU17290" /label="ebrB gene" downshifts complement(1666254) /Source="Nicolas_upshifts" /id="D934" /incds=0 /nref=2 /ntot=45 /MaxReadThrough="0.84905" /MaxDrop="2.87924" /score="-2.89884673" /energy="-8.7" /TU="NA" /idTUdmin="U1381" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(1666580..1666897) /gene="ebrA" /locus_tag="BSU_17300" /old_locus_tag="BSU17300" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735876, 11104814, 17516673, 18024586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735876, 11104814, 17516673, 18024586; Product type t: transporter" /codon_start=1 /transl_table=11 /product="small toxic metabolite efflux transporter subunit" /protein_id="NP_389612.1" /db_xref="EnsemblGenomes-Gn:BSU17300" /db_xref="EnsemblGenomes-Tr:CAB13614" /db_xref="GOA:P0CW80" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12585" /db_xref="UniProtKB/Swiss-Prot:P0CW80" /translation="MLIGYIFLTIAICSESIGAAMLKVSDGFKKWKPSALVVIGYSLA FYMLSLTLNHIPLSLSYATWSGAGTVLTTVIGVKWFKEDLNAKGLIGILLLLSGVVLL NWP*" /label="ebrA CDS" gene complement(1666580..1666897) /gene="ebrA" /locus_tag="BSU_17300" /old_locus_tag="BSU17300" /label="ebrA gene" promotor_-10 complement(1666941..1666960) /Source="Nicolas_upshift_promotors" /id="U1381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.843156843156843" /psig="0.998001998001998" /xcortree=1863 /SigmaFactorBS="gtctttttaagtgtgtgaaaatgaatcTCTTGACTcatacat aggcataCACTAATATTTTTCTAGCTGaagttttttttctaatctaaaaatatagtga g" /listShort="ebrA, ebrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1666949) /Source="Nicolas_upshifts" /id="U1381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.843156843156843" /psig="0.998001998001998" /xcortree=1863 /SigmaFactorBS="gtctttttaagtgtgtgaaaatgaatcTCTTGACTcatacat aggcataCACTAATATTTTTCTAGCTGaagttttttttctaatctaaaaatatagtga g" /listShort="ebrA, ebrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1666975..1666982) /Source="Nicolas_upshift_promotors" /id="U1381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.843156843156843" /psig="0.998001998001998" /xcortree=1863 /SigmaFactorBS="gtctttttaagtgtgtgaaaatgaatcTCTTGACTcatacat aggcataCACTAATATTTTTCTAGCTGaagttttttttctaatctaaaaatatagtga g" /listShort="ebrA, ebrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1667034..1667309) /gene="ymaG" /locus_tag="BSU_17310" /old_locus_tag="BSU17310" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19775244, 19933362, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19775244, 19933362, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein; cell wall associated protein" /protein_id="NP_389613.2" /db_xref="EnsemblGenomes-Gn:BSU17310" /db_xref="EnsemblGenomes-Tr:CAB13615" /db_xref="GOA:O31793" /db_xref="SubtiList:BG13415" /db_xref="UniProtKB/Swiss-Prot:O31793" /translation="MNELEHFSPEDTRIFGRPFGFGRPFGFGRPFGFGYGFGRPGFGY GFGRPFGFFGGPFIGGLAGGLIGSALFNPYLYGGYPYYPYAPFPFYY*" /label="ymaG CDS" gene complement(1667034..1667309) /gene="ymaG" /locus_tag="BSU_17310" /old_locus_tag="BSU17310" /label="ymaG gene" downshifts complement(1667035) /Source="Nicolas_upshifts" /id="D935" /incds=0 /nref=38 /ntot=44 /MaxReadThrough="0.28059" /MaxDrop="8.33353" /score="12.3408391" /energy="-11.5" /TU="NA" /idTUdmin="U1383" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1667305..1667310 /Source="Nicolas_upshift_promotors" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="promotor_-35" promotor_-10 1667326..1667344 /Source="Nicolas_upshift_promotors" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="promotor_-10" promotor_-10 complement(1667336..1667355) /Source="Nicolas_upshift_promotors" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1667346 /Source="Nicolas_upshifts" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="upshifts" upshifts complement(1667349) /Source="Nicolas_upshifts" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1667368..1667377) /Source="Nicolas_upshift_promotors" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1667398..1667811 /gene="ymaF" /locus_tag="BSU_17320" /old_locus_tag="BSU17320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 24098137, 25915524" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein of unknown function" /protein_id="NP_389614.2" /db_xref="EnsemblGenomes-Gn:BSU17320" /db_xref="EnsemblGenomes-Tr:CAB13616" /db_xref="InterPro:IPR024307" /db_xref="SubtiList:BG13414" /db_xref="UniProtKB/Swiss-Prot:O31794" /translation="MNTLGLYQSDWSKAPPHAHAYHVKTTREQGHYHLIEGFTQPANG SNTDQHTHYYTGITSFENGHFHRYYGISGPAIPLADGTHYHEIEETTYLAYNEPIEIQ YGGVVYDPGDDRRKTHRHTLKGKTREIVGNEPLGW*" /label="ymaF CDS" gene 1667398..1667811 /gene="ymaF" /locus_tag="BSU_17320" /old_locus_tag="BSU17320" /label="ymaF gene" upshifts 1667862 /Source="Nicolas_upshifts" /id="U1384" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig="0.883116883116883" /xcortree=2366 /SigmaFactorBS="cggctggtagaaggatgtttaccgatgcaaaaaaagggcaaa atggataggtggttgtccatgttgAATGCTATAATGGGGGGAGAtttataaaagagag t" /listShort="miaA, ymaH" /listLong="ymzC, ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB" /label="upshifts" misc_feature 1667868..1667887 /Source="Nicolas_upshift_promotors" /id="U1384" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig="0.883116883116883" /xcortree=2366 /SigmaFactorBS="cggctggtagaaggatgtttaccgatgcaaaaaaagggcaaa atggataggtggttgtccatgttgAATGCTATAATGGGGGGAGAtttataaaagagag t" /listShort="miaA, ymaH" /listLong="ymzC, ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1667911..1668855 /gene="miaA" /locus_tag="BSU_17330" /old_locus_tag="BSU17330" /EC_number="2.5.1.75" /function="16.3: Control" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3045085, 11160115, 26735940, 28277934, 28471404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA isopentenylpyrophosphate transferase" /protein_id="NP_389615.2" /db_xref="EnsemblGenomes-Gn:BSU17330" /db_xref="EnsemblGenomes-Tr:CAB13617" /db_xref="GOA:O31795" /db_xref="InterPro:IPR018022" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12617" /db_xref="UniProtKB/Swiss-Prot:O31795" /translation="MNNTKQPVVILVGPTAVGKTNLSIQLAKSLNAEIISGDSMQIYK GMDIGTAKITEQEMEGVPHHLIDILDPQDSFSTADYQSLVRNKISEIANRGKLPMIVG GTGLYIQSVLYDYTFTEEANDPVFRESMQMAAEREGADFLHAKLAAADPEAAAAIHPN NTRRVIRALEILHTSGKTMSQHLKEQKRELLYNAVLIGLTMDRDTLYERINQRVDLMM QSGLLPEVKRLYDKNVRDCQSIQAIGYKELYAYFDGFVTLSDAVEQLKQNSRRYAKRQ LTWFRNKMQVTWFDMTPPVDMELKKKEIFTHIAGKLEL*" /label="miaA CDS" gene 1667911..1668855 /gene="miaA" /locus_tag="BSU_17330" /old_locus_tag="BSU17330" /label="miaA gene" promotor_-35 1668835..1668843 /Source="Nicolas_upshift_promotors" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="promotor_-35" promotor_-10 1668854..1668872 /Source="Nicolas_upshift_promotors" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="promotor_-10" upshifts 1668856 /Source="Nicolas_upshifts" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="upshifts" CDS 1668895..1669116 /gene="hfq" /locus_tag="BSU_17340" /old_locus_tag="BSU17340" /function="16.3: Control" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16166525, 20445260, 22053080, 23457461, 24932523, 27049793, 27581927" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16166525, 20445260, 22053080, 23457461, 24932523, 27049793, 27581927; Product type f: factor" /codon_start=1 /transl_table=11 /product="Hfq RNA chaperone" /protein_id="NP_389616.1" /db_xref="EnsemblGenomes-Gn:BSU17340" /db_xref="EnsemblGenomes-Tr:CAB13618" /db_xref="GOA:O31796" /db_xref="InterPro:IPR005001" /db_xref="InterPro:IPR010920" /db_xref="PDB:3AHU" /db_xref="PDB:3HSB" /db_xref="SubtiList:BG13416" /db_xref="UniProtKB/Swiss-Prot:O31796" /translation="MKPINIQDQFLNQIRKENTYVTVFLLNGFQLRGQVKGFDNFTVL LESEGKQQLIYKHAISTFAPQKNVQLELE*" /label="hfq CDS" gene 1668895..1669116 /gene="hfq" /locus_tag="BSU_17340" /old_locus_tag="BSU17340" /label="hfq gene" downshifts complement(1668906) /Source="Nicolas_upshifts" /id="D936" /incds=0 /nref=3 /ntot=108 /MaxReadThrough="1.19472" /MaxDrop="3.56162" /score="-5.83707008" /energy="-5.2" /TU="NA" /idTUdmin="U1386" /TUdmin=22 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1668968..1668972) /Source="Nicolas_upshift_promotors" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1668972) /Source="Nicolas_upshifts" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1668987..1668992) /Source="Nicolas_upshift_promotors" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1669116 /Source="Nicolas_upshifts" /id="D937" /incds=0 /nref=26 /ntot=212 /MaxReadThrough="5.10866" /MaxDrop="4.06475" /score="17.2354231" /energy="-17" /TU="U1382,U1385" /idTUdmin="U1384" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1669312..1669584 /gene="ymzC" /locus_tag="BSU_17350" /old_locus_tag="BSU17350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389617.1" /db_xref="EnsemblGenomes-Gn:BSU17350" /db_xref="EnsemblGenomes-Tr:CAB13619" /db_xref="InterPro:IPR025448" /db_xref="PDB:3KVP" /db_xref="SubtiList:BG13436" /db_xref="UniProtKB/Swiss-Prot:O31797" /translation="MFESEAELRRIRIALVWIAVFLLFGACGNQDTIIETDNGNSDYE TPQPTSFPLEHNHFGVMEDGYIKIYEYNESRNEVKLKKEYADDELE*" /label="ymzC CDS" gene 1669312..1669584 /gene="ymzC" /locus_tag="BSU_17350" /old_locus_tag="BSU17350" /label="ymzC gene" promotor_-35 1669600..1669607 /Source="Nicolas_upshift_promotors" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1669621..1669640 /Source="Nicolas_upshift_promotors" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1669623 /Source="Nicolas_upshifts" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="upshifts" CDS 1669666..1669896 /gene="ymzA" /locus_tag="BSU_17360" /old_locus_tag="BSU17360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389618.1" /db_xref="EnsemblGenomes-Gn:BSU17360" /db_xref="EnsemblGenomes-Tr:CAB13620" /db_xref="SubtiList:BG13434" /db_xref="UniProtKB/Swiss-Prot:O31798" /translation="MKHKVIVNHWEEICEDDSCYEYGTSIIVNGKELIREASIITALK AVLEEIGADVEIEETVESEKCCDSLRKKNLDY*" /label="ymzA CDS" gene 1669666..1669896 /gene="ymzA" /locus_tag="BSU_17360" /old_locus_tag="BSU17360" /label="ymzA gene" S_feature 1669897..1669973 /Source="Nicolas_S_feature" /locus_tag="new_1868375_1868451" /HighExp="dia5, dia15, Diami, B60, G150, H2O2, LPhT, G180, G135, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.883" /label="S620" downshifts 1669930 /Source="Nicolas_upshifts" /id="D938" /incds=0 /nref=24 /ntot=61 /MaxReadThrough="7.47169" /MaxDrop="4.19691" /score="8.2587309" /energy="-16.9" /TU="U1385,U1387" /idTUdmin="U1385" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" S_feature 1669975..1670082 /Source="Nicolas_S_feature" /locus_tag="new_1868453_1868560" /HighExp="G180, G150, G135, H2O2, dia15, Paraq, LBGexp, C30, Diami, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.883" /label="S621" promotor_-35 1670055..1670062 /Source="Nicolas_upshift_promotors" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1670076..1670095 /Source="Nicolas_upshift_promotors" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1670084 /Source="Nicolas_upshifts" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="upshifts" CDS 1670139..1670531 /gene="nrdI" /locus_tag="BSU_17370" /old_locus_tag="BSU17370" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16885274, 21561096, 22443445, 23402532, 26507228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16885274, 21561096, 22443445, 23402532, 26507228; Product type f : factor" /codon_start=1 /transl_table=11 /product="co-factor of ribonucleotide diphosphate reductase" /protein_id="NP_389619.1" /db_xref="EnsemblGenomes-Gn:BSU17370" /db_xref="EnsemblGenomes-Tr:CAB13621" /db_xref="GOA:P50618" /db_xref="InterPro:IPR004465" /db_xref="InterPro:IPR020852" /db_xref="InterPro:IPR029039" /db_xref="PDB:1RLJ" /db_xref="SubtiList:BG11426" /db_xref="UniProtKB/Swiss-Prot:P50618" /translation="MVQIIFDSKTGNVQRFVNKTGFQQIRKVDEMDHVDTPFVLVTYT TNFGQVPASTQSFLEKYAHLLLGVAASGNKVWGDNFAKSADTISRQYQVPILHKFELS GTSKDVELFTQEVERVVTKSSAKMDPVK*" /label="nrdI CDS" gene 1670139..1670531 /gene="nrdI" /locus_tag="BSU_17370" /old_locus_tag="BSU17370" /label="nrdI gene" CDS 1670491..1672593 /gene="nrdE" /locus_tag="BSU_17380" /old_locus_tag="BSU17380" /EC_number="1.17.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonucleoside-diphosphate reductase (major subunit)" /protein_id="NP_389620.1" /db_xref="EnsemblGenomes-Gn:BSU17380" /db_xref="EnsemblGenomes-Tr:CAB13622" /db_xref="GOA:P50620" /db_xref="InterPro:IPR000788" /db_xref="InterPro:IPR008926" /db_xref="InterPro:IPR013346" /db_xref="InterPro:IPR013509" /db_xref="InterPro:IPR013554" /db_xref="InterPro:IPR026459" /db_xref="SubtiList:BG11404" /db_xref="UniProtKB/Swiss-Prot:P50620" /translation="MSQNQVPKWIQLNNEIMIQKDGKFQFDKDKEAVHSYFVDYINQN TVFFHNLKEKLDYLVENQYYEEEFLSLYSFEDIKEVFKTAYAKKFRFPSFMSAFKFYN DYALKTNDKKKILERYEDRISIVALFFANGDTEKAKEYVNLMINQEYQPSTPTFLNAG RKRRGELVSCFLLEVNDSLNDISRAIDISMQLSKLGGGVSLNLSKLRAKGEAIKDVEN ATKGVVGVMKLLDNAFRYADQMGQRQGSGAAYLNIFHRDINDFLDTKKISADEDVRVK TLSIGVVIPDKFVELAREDKAAYVFYPHTIYKEYGQHMDEMDMNEMYDKFVDNPRVKK EKINPRKLLEKLAMLRSESGYPYIMFQDNVNKVHANNHISKVKFSNLCSEVLQASQVS SYTDYDEEDEIGLDISCNLGSLNILNVMEHKSIEKTVKLATDSLTHVSETTDIRNAPA VRRANKAMKSIGLGAMNLHGYLAQNGIAYESPEARDFANTFFMMVNFYSIQRSAEIAK EKGETFDQYEGSTYATGEYFDKYVSTDFSPKYEKIANLFEGMHIPTTEDWKKLKAFVA EHGMYHSYRLCIAPTGSISYVQSSTASVMPIMERIEERTYGNSKTYYPMPGLASNNWF FYKEAYDMDMFKVVDMIATIQQHIDQGISFTLFLKDTMTTRDLNRIDLYAHHRGIKTI YYARTKDTGQDSCLSCVV*" /label="nrdE CDS" gene 1670491..1672593 /gene="nrdE" /locus_tag="BSU_17380" /old_locus_tag="BSU17380" /label="nrdE gene" CDS 1672611..1673600 /gene="nrdF" /locus_tag="BSU_17390" /old_locus_tag="BSU17390" /EC_number="1.17.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonucleoside-diphosphate reductase (minor subunit)" /protein_id="NP_389621.1" /db_xref="EnsemblGenomes-Gn:BSU17390" /db_xref="EnsemblGenomes-Tr:CAB13623" /db_xref="GOA:P50621" /db_xref="InterPro:IPR000358" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR026494" /db_xref="InterPro:IPR030475" /db_xref="InterPro:IPR033909" /db_xref="PDB:4DR0" /db_xref="SubtiList:BG11405" /db_xref="UniProtKB/Swiss-Prot:P50621" /translation="MTKIYDAANWSKHEDDFTQMFYNQNVKQFWLPEEIALNGDLLTW KYLGKNEQDTYMKVLAGLTLLDTEQGNTGMPIVAEHVDGHQRKAVLNFMAMMENAVHA KSYSNIFMTLAPTETINEVFEWVKQNKYLQKKAQMIVGLYKAIQKDDEISLFKAMVAS VYLESFLFYSGFYYPLYFYGQGKLMQSGEIINLILRDEAIHGVYVGLLAQEIYNKQTE EKKAELREFAIDLLNQLYENELEYTEDLYDQVGLSHDVKKFIRYNANKALMNLGFDPY FEEEDINPIVLNGLNTKTKSHDFFSMKGNGYKKATVEPLKDDDFYFEDEKEQI*" /label="nrdF CDS" gene 1672611..1673600 /gene="nrdF" /locus_tag="BSU_17390" /old_locus_tag="BSU17390" /label="nrdF gene" downshifts 1673560 /Source="Nicolas_upshifts" /id="D939" /incds=0 /nref=3 /ntot=106 /MaxReadThrough="6.49299" /MaxDrop="2.8143" /score="-8.26008921" /energy="-10.8" /TU="U1387,U1388" /idTUdmin="U1388" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" S_feature complement(1673614..1674273) /Source="Nicolas_S_feature" /locus_tag="new_1872092_1872751_c" /HighExp="BT, B36, C30, Pyr, S8, G135, G/S, Glucon, B60, C90" /AntisenseName="ymaB" /AntisenseCor="-0.136438199650502" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S622" downshifts complement(1673629) /Source="Nicolas_upshifts" /id="D940" /incds=0 /nref=3 /ntot=8 /MaxReadThrough="2.78803" /MaxDrop="4.0424" /score="6.77419677" /energy="-10.8" /TU="NA" /idTUdmin="U1390" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS 1673650..1674270 /gene="ymaB" /locus_tag="BSU_17400" /old_locus_tag="BSU17400" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16885274, 21561096; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative cofactor involved in deoxyribonucleotide synthesis" /protein_id="NP_389622.1" /db_xref="EnsemblGenomes-Gn:BSU17400" /db_xref="EnsemblGenomes-Tr:CAB13624" /db_xref="GOA:P50619" /db_xref="InterPro:IPR015797" /db_xref="SubtiList:BG11427" /db_xref="UniProtKB/Swiss-Prot:P50619" /translation="MGKMDEMILVAPRDDVFKKESLTFQGVYSEDSRVAEIMAQIEAA YREMRRGDAEEDPRFKQPIPYVVIKREDEVFLYERLAGGGESRLHNKLSLGFGGHMNA IEGAASFAEVLKLNTDRELEEELQINEEDKQAIVTLGLINDDENSVGKVHIGILSALQ LKPGAQVEVKEKEQIAGKWMKVSELKQDDIYNRLETWSQFVVDILE*" /label="ymaB CDS" gene 1673650..1674270 /gene="ymaB" /locus_tag="BSU_17400" /old_locus_tag="BSU17400" /label="ymaB gene" downshifts 1674251 /Source="Nicolas_upshifts" /id="D941" /incds=0 /nref=130 /ntot=257 /MaxReadThrough="4.3301" /MaxDrop="6.0751" /score="31.3992458" /energy="-16.3" /TU="U1387,U1388" /idTUdmin="U1388" /TUdmin="-35" /isTUend="FALSE" /label="downshifts" promotor_-35 1674286..1674290 /Source="Nicolas_upshift_promotors" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1674308..1674675 /Source="Nicolas_S_feature" /locus_tag="new_1872786_1873153" /HighExp="dia15, G180, H2O2, G135, G150, Diami, Paraq, Oxctl, LBGexp, C30" /AntisenseName="cwlC" /AntisenseCor="-8.9131707018362205E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.231, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S623" upshifts 1674308 /Source="Nicolas_upshifts" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1674312..1674329 /Source="Nicolas_upshift_promotors" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(1674318) /Source="Nicolas_upshifts" /id="D942" /incds=0 /nref=1 /ntot=53 /MaxReadThrough="7.25519" /MaxDrop="4.6417" /score="9.14776993" /energy="-8.9" /TU="U1390" /idTUdmin="U1390" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" CDS complement(1674334..1675101) /gene="cwlC" /locus_tag="BSU_17410" /old_locus_tag="BSU17410" /EC_number="3.5.1.28" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10515909, 10945275, 10974124, 11375403, 16042392" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10515909, 10945275, 10974124, 11375403, 16042392; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase (sporulation-specific)" /protein_id="NP_389623.2" /db_xref="EnsemblGenomes-Gn:BSU17410" /db_xref="EnsemblGenomes-Tr:CAB13625" /db_xref="GOA:Q06320" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR007730" /db_xref="InterPro:IPR036680" /db_xref="PDB:1X60" /db_xref="SubtiList:BG10825" /db_xref="UniProtKB/Swiss-Prot:Q06320" /translation="MVKIFIDPGHGGSDPGATGNGLQEKTLTLQIALALRTILTNEYE GVSLLLSRTSDQYVSLNDRTNAANNWGADFFLSIHVNSGGGTGFESYIYPDVGAPTTT YQSTIHSEVIQAVDFADRGKKTANFHVLRESAMPALLTENGFIDTVSDANKLKTSSFI QSLARGHANGLEQAFNLKKTSSSGLYKVQIGAFKVKANADSLASNAEAKGFDSIVLLK DGLYKVQIGAFSSKDNADTLAARAKNAGFDAIVILES*" /label="cwlC CDS" gene complement(1674334..1675101) /gene="cwlC" /locus_tag="BSU_17410" /old_locus_tag="BSU17410" /label="cwlC gene" promotor_-10 complement(1675110..1675129) /Source="Nicolas_upshift_promotors" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1675133) /Source="Nicolas_upshifts" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1675142..1675151) /Source="Nicolas_upshift_promotors" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1675255..1675260 /Source="Nicolas_upshift_promotors" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1675276..1675294 /Source="Nicolas_upshift_promotors" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1675276 /Source="Nicolas_upshifts" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1675558..1675563 /Source="Nicolas_upshift_promotors" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="promotor_-35" promotor_-10 1675580..1675598 /Source="Nicolas_upshift_promotors" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="promotor_-10" S_feature 1675584..1675724 /Source="Nicolas_S_feature" /locus_tag="new_1874062_1874202" /HighExp="S4, S5, S6, S8, S3, B60, LoTm, S7, T5.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.777" /TUlongSig="NA" /TUlongPSig="NA" /label="S624" upshifts 1675584 /Source="Nicolas_upshifts" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="upshifts" CDS 1675725..1676693 /gene="spoVK" /locus_tag="BSU_17420" /old_locus_tag="BSU17420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8464402, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8464402, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="mother cell sporulation ATPase" /protein_id="NP_389624.2" /db_xref="EnsemblGenomes-Gn:BSU17420" /db_xref="EnsemblGenomes-Tr:CAB13626" /db_xref="GOA:P27643" /db_xref="InterPro:IPR000641" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR014232" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11039" /db_xref="UniProtKB/Swiss-Prot:P27643" /translation="MLERAVTYKNNGQINIILNGQKQVLTNAEAEAEYQAALQKNEAK HGILKEIEKEMSALVGMEEMKRNIKEIYAWIFVNQKRAEQGLKVGKQALHMMFKGNPG TGKTTVARLIGKLFFEMNVLSKGHLIEAERADLVGEYIGHTAQKTRDLIKKSLGGILF IDEAYSLARGGEKDFGKEAIDTLVKHMEDKQHEFILILAGYSREMDHFLSLNPGLQSR FPISIDFPDYSVTQLMEIAKRMIDEREYQLSQEAEWKLKDYLMTVKSTTSPIKFSNGR FVRNVIEKSIRAQAMRLLMGDQYLKSDLMTIKSQDLSIKEEASGSA*" /label="spoVK CDS" gene 1675725..1676693 /gene="spoVK" /locus_tag="BSU_17420" /old_locus_tag="BSU17420" /label="spoVK gene" downshifts 1676662 /Source="Nicolas_upshifts" /id="D943" /incds=0 /nref=5 /ntot=41 /MaxReadThrough="2.7881" /MaxDrop="5.20495" /score="22.9164064" /energy="-15.5" /TU="U1392" /idTUdmin="U1392" /TUdmin="-109" /isTUend="FALSE" /label="downshifts" promotor_-35 1676757..1676765 /Source="Nicolas_upshift_promotors" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="promotor_-35" upshifts 1676772 /Source="Nicolas_upshifts" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="upshifts" promotor_-10 1676776..1676795 /Source="Nicolas_upshift_promotors" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="promotor_-10" CDS 1676826..1678088 /gene="hflX" /locus_tag="BSU_17430" /old_locus_tag="BSU17430" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 19824612, 26458047, 26733579, 26951678, 27398305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-splitting GTPase (also ATPase, rescuingstalled ribosomes, E-site binding)" /protein_id="NP_389625.2" /db_xref="EnsemblGenomes-Gn:BSU17430" /db_xref="EnsemblGenomes-Tr:CAB13627" /db_xref="GOA:P94478" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR016496" /db_xref="InterPro:IPR025121" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030394" /db_xref="InterPro:IPR032305" /db_xref="SubtiList:BG12263" /db_xref="UniProtKB/Swiss-Prot:P94478" /translation="MNEQETIQEKAILVGCQLPHITDEHFENSMEELASLTKTADGKV LTSVTQKRNRADAATYIGKGKVEELKALVEELEADLLIFNDELSPSQLKSLATAIEVK MIDRTQLILDIFAKRARTREGKLQIELAQLQYALPRLTGQGINLSRQGGGIGARGPGE TKLETDRRHIRNRIHEINTQLSTVIRHRSRYRERRKKNGVLQIALVGYTNAGKSTWFN RLTSADSYEEDLLFATLDPMTRKMVLPSGYSVLLSDTVGFIQDLPTTLIAAFRSTLEE VKEADLILHLIDSSNEDYAGHEKTVLRLLEELEADDIPMLTAYNKRDQKLPDFIPTAG RDHIMVSAKFEDDAAAFKEAIQRYLRQELLTSFEAHVPASEGKLLSRIKSETMVDRFY FNEENEQYDISGYVQEEQSIIGELKKYM*" /label="hflX CDS" gene 1676826..1678088 /gene="hflX" /locus_tag="BSU_17430" /old_locus_tag="BSU17430" /label="hflX gene" CDS 1678106..1679371 /gene="ynbB" /locus_tag="BSU_17440" /old_locus_tag="BSU17440" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 24610841; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative C-S lyase" /protein_id="NP_389626.2" /db_xref="EnsemblGenomes-Gn:BSU17440" /db_xref="EnsemblGenomes-Tr:CAB13628" /db_xref="GOA:P94479" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR009651" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12264" /db_xref="UniProtKB/Swiss-Prot:P94479" /translation="MFDTLTHGELLKKTAMEVEADIAGIHKQIEEISERNEWRVLQSY RKHKVSDTHFTPSTGYGYDDIGRDTLESIYADVFGGEAGLVRPQIISGTHAISIALFG VLRPGDELLYITGKPYDTLEEIVGVRGGENAGSLKDFQIGYNAVDLTKDGKIDYDAVA AAINPKTKVIGIQRSKGYANRPSFLISEIKEMIRFVKEINENLIVFVDNCYGEFVEEL EPCHVGADLMAGSLIKNPGGGLAKTGGYLVGKAKWIEACSYRMTSPGIGREAGASLYS LQEMYQGFFLAPHVVSQSLKGAVFTARFLEKLGFTSNPKWDAKRTDLIQSVEFSDREK MIAFCQAIQFASPINAHVTPYPAYMPGYEDDVIMAAGTFIQGASIELSADGPIRPPYV AYVQGGLTYSHVKNAICSAVDSLMQKQLI*" /label="ynbB CDS" gene 1678106..1679371 /gene="ynbB" /locus_tag="BSU_17440" /old_locus_tag="BSU17440" /label="ynbB gene" promotor_-35 1679419..1679426 /Source="Nicolas_upshift_promotors" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="promotor_-35" promotor_-10 1679441..1679460 /Source="Nicolas_upshift_promotors" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="promotor_-10" upshifts 1679453 /Source="Nicolas_upshifts" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="upshifts" CDS 1679481..1679888 /gene="glnR" /locus_tag="BSU_17450" /old_locus_tag="BSU17450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9287005, 12374841, 16547045, 16885465, 22625175, 22720735, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12374841, 16547045, 16885465, 22625175, 22720735, 25691471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (nitrogen metabolism)" /protein_id="NP_389627.1" /db_xref="EnsemblGenomes-Gn:BSU17450" /db_xref="EnsemblGenomes-Tr:CAB13629" /db_xref="GOA:P37582" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="PDB:4R4E" /db_xref="SubtiList:BG10424" /db_xref="UniProtKB/Swiss-Prot:P37582" /translation="MSDNIRRSMPLFPIGIVMQLTELSARQIRYYEENGLIFPARSEG NRRLFSFHDVDKLLEIKHLIEQGVNMAGIKQILAKAEAEPEQKQNEKTKKPMKHDLSD DELRQLLKNELMQAGRFQRGNTFRQGDMSRFFH*" /label="glnR CDS" gene 1679481..1679888 /gene="glnR" /locus_tag="BSU_17450" /old_locus_tag="BSU17450" /label="glnR gene" downshifts complement(1679487) /Source="Nicolas_upshifts" /id="D944" /incds=0 /nref=2 /ntot=82 /MaxReadThrough="1.78139" /MaxDrop="3.45896" /score="-7.83781174" /energy="-10.3" /TU="NA" /idTUdmin="U1398" /TUdmin=3816 /isTUend="FALSE" /label="downshifts" misc_feature 1679869..1679887 /Source="Nicolas_upshift_promotors" /id="U1395" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=2197 /SigmaFactorBS="ttttcaaagagggaatacattccgtcaaggcgacaTGTCCCG CTTCTTTCATTAatccgttagcaactgttttgctatatacatttaccttttaagagga g" /listShort="glnA, S625, ynxB, S626" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1679894 /Source="Nicolas_upshifts" /id="U1395" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=2197 /SigmaFactorBS="ttttcaaagagggaatacattccgtcaaggcgacaTGTCCCG CTTCTTTCATTAatccgttagcaactgttttgctatatacatttaccttttaagagga g" /listShort="glnA, S625, ynxB, S626" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1679947) /Source="Nicolas_upshifts" /id="D945" /incds=0 /nref=1 /ntot=72 /MaxReadThrough="1.70567" /MaxDrop="3.42395" /score="-7.83781174" /energy="-10.3" /TU="NA" /idTUdmin="U1398" /TUdmin=3356 /isTUend="FALSE" /label="downshifts" CDS 1679947..1681281 /gene="glnA" /locus_tag="BSU_17460" /old_locus_tag="BSU17460" /EC_number="6.3.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:13737, 11719184, 12142436, 16055443, 16885465, 19233925, 19251843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 13737, 11719184, 12142436, 16055443, 16885465, 19233925, 19251843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine synthetase" /protein_id="NP_389628.1" /db_xref="EnsemblGenomes-Gn:BSU17460" /db_xref="EnsemblGenomes-Tr:CAB13630" /db_xref="GOA:P12425" /db_xref="InterPro:IPR001637" /db_xref="InterPro:IPR004809" /db_xref="InterPro:IPR008146" /db_xref="InterPro:IPR008147" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR027302" /db_xref="InterPro:IPR027303" /db_xref="InterPro:IPR036651" /db_xref="PDB:2FWX" /db_xref="PDB:4LNF" /db_xref="PDB:4LNI" /db_xref="PDB:4LNK" /db_xref="PDB:4LNN" /db_xref="PDB:4LNO" /db_xref="PDB:4S0R" /db_xref="SubtiList:BG10425" /db_xref="UniProtKB/Swiss-Prot:P12425" /translation="MAKYTREDIEKLVKEENVKYIRLQFTDILGTIKNVEIPVSQLGK ALDNKVMFDGSSIEGFVRIEESDMYLYPDLNTFVIFPWTAEKGKVARFICDIYNPDGT PFEGDPRNNLKRILKEMEDLGFSDFNLGPEPEFFLFKLDEKGEPTLELNDKGGYFDLA PTDLGENCRRDIVLELEEMGFEIEASHHEVAPGQHEIDFKYAGAVRSCDDIQTFKLVV KTIARKHGLHATFMPKPLFGVNGSGMHCNLSLFKNGVNAFFDENADLQLSETAKHFIA GIVKHATSFTAVTNPTVNSYKRLVPGYEAPCYVAWSAQNRSPLIRIPASRGISTRVEV RSVDPAANPYLALSVLLAAGLDGIKNKLEAPAPIDRNIYVMSKEERMENGIVDLPATL AEALEEFKSNEVMVKALGEHLFEHFIEAKEIEWDMFRTQVHPWEREQYMSQY*" /label="glnA CDS" gene 1679947..1681281 /gene="glnA" /locus_tag="BSU_17460" /old_locus_tag="BSU17460" /label="glnA gene" downshifts 1681258 /Source="Nicolas_upshifts" /id="D946" /incds=0 /nref=266 /ntot=287 /MaxReadThrough="5.53201" /MaxDrop="7.28613" /score="29.7599306" /energy="-16.4" /TU="U1394,U1395" /idTUdmin="U1393" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature 1681303..>1681352 /Source="Nicolas_S_feature" /locus_tag="new_1879781_1880041" /HighExp="Cold, BT, LBGtran, G135, G180, Etha, G150, LBGexp, Oxctl, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.777, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S625" SCAR 1681352..1681353 /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="IIG_Bs04" S_feature <1681353..1682105 /Source="Nicolas_S_feature" /locus_tag="new_1886528_1887351" /HighExp="Lbstat, M0t90, S8, C30, Pyr, Lbtran, M40t90, S1, M/G, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S631" promotor_-10 complement(1681445..1681463) /Source="Nicolas_upshift_promotors" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1681463) /Source="Nicolas_upshifts" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1681479..1681484) /Source="Nicolas_upshift_promotors" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1682106..1683497 /gene="xynP" /locus_tag="BSU_17570" /old_locus_tag="BSU17570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16684115, 16850406, 17183216, 20406496; Product type t : transporter" /codon_start=1 /transl_table=11 /product="H+-xyloside symporter" /protein_id="NP_389639.2" /db_xref="EnsemblGenomes-Gn:BSU17570" /db_xref="EnsemblGenomes-Tr:CAB13641" /db_xref="GOA:P94488" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12262" /db_xref="UniProtKB/Swiss-Prot:P94488" /translation="MLSENVKKISMVEKVGYASGDFACNLIYATVSTYLLFFYTDVFG LSAAAAGTMFLVVRIIDALADPFIGTIVDRTNSRFGRFRPYLLFGAFPFVILAILCFT TPDFSDMGKLIYAYITYVGLSLTYTTINVPYGALTSAMTRNNQEVVSITSVRMLFANL GGLVVAFFVPLLAAYLSDTSGNESLGWQLTMGILGMIGGCLLIFCFKSTKERVTLQKS EEKIKFTDIFEQFRVNRPLVVLSIFFIIIFGVNSISNSVGIYYVTYNLEREDLVKWYG LIGSLPALVILPFIPRLHQFLGKKKLLNYALLLNIIGLLALLFVPPSNVYLILVCRLI AAAGSLTAGGYMWALIPETIEYGEYRTGKRMGGLIYAIIGFFFKFGMALGGVVPGLVL DKFGYVANQAQTPAALMGILITTTIIPVFLLVLALIDINFYNLDEKKYKNMVRELENR DKVYLDHIDDFKA*" /label="xynP CDS" gene 1682106..1683497 /gene="xynP" /locus_tag="BSU_17570" /old_locus_tag="BSU17570" /label="xynP gene" CDS 1683528..1685129 /gene="xynB" /locus_tag="BSU_17580" /old_locus_tag="BSU17580" /EC_number="3.2.1.37" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2440680, 6413490, 7816035, 9286998, 9973552, 16684115, 28066362; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylan beta-1,4-xylosidase" /protein_id="NP_389640.2" /db_xref="EnsemblGenomes-Gn:BSU17580" /db_xref="EnsemblGenomes-Tr:CAB13642" /db_xref="GOA:P94489" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR023296" /db_xref="PDB:1YIF" /db_xref="SubtiList:BG11987" /db_xref="UniProtKB/Swiss-Prot:P94489" /translation="MKITNPVLKGFNPDPSICRAGEDYYIAVSTFEWFPGVQIHHSKD LVNWHLVAHPLQRVSQLDMKGNPNSGGVWAPCLSYSDGKFWLIYTDVKVVDGAWKDCH NYLVTCETINGDWSEPIKLNSSGFDASLFHDTDGKKYLLNMLWDHRIDRHSFGGIVIQ EYSDKEQKLIGKPKVIFEGTDRKLTEAPHLYHIGNYYYLLTAEGGTRYEHAATIARSA NIEGPYEVHPDNPILTSWHDPGNPLQKCGHASIVQTHTDEWYLAHLTGRPIHPDDDSI FQQRGYCPLGRETAIQKLYWKDEWPYVVGGKEGSLEVDAPSIPETIFEATYPEVDEFE DSTLNINFQTLRIPFTNELGSLTQAPNHLRLFGHESLTSTFTQAFVARRWQSLHFEAE TAVEFYPENFQQAAGLVNYYNTENWTALQVTHDEELGRILELTICDNFSFSQPLNNKI VIPREVKYVYLRVNIEKDKYYYFYSFNKEDWHKIDIALESKKLSDDYIRGGGFFTGAF VGMQCQDTSGNHIPADFRYFRYKEK*" /label="xynB CDS" gene 1683528..1685129 /gene="xynB" /locus_tag="BSU_17580" /old_locus_tag="BSU17580" /label="xynB gene" S_feature complement(1683644..1683949) /Source="Nicolas_S_feature" /locus_tag="new_1888890_1889195_c" /HighExp="S8, S6, S7, BT, C30, S5, Pyr, S4, B36, BC" /AntisenseName="xynB" /AntisenseCor="6.2527836498644102E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S632" promotor_-10 complement(1683944..1683963) /Source="Nicolas_upshift_promotors" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1683949) /Source="Nicolas_upshifts" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1683977..1683985) /Source="Nicolas_upshift_promotors" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1685127 /Source="Nicolas_upshifts" /id="D951" /incds=0 /nref=2 /ntot=53 /MaxReadThrough="1.32947" /MaxDrop="3.8449" /score="13.0570501" /energy="-10.2" /TU="NA" /idTUdmin="U1400" /TUdmin=3190 /isTUend="FALSE" /label="downshifts" CDS complement(1685266..1686420) /gene="xylR" /locus_tag="BSU_17590" /old_locus_tag="BSU17590" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1588910, 1719948, 2544559, 7559331; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_389641.3" /db_xref="EnsemblGenomes-Gn:BSU17590" /db_xref="EnsemblGenomes-Tr:CAB13643" /db_xref="GOA:P94490" /db_xref="InterPro:IPR000600" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11986" /db_xref="UniProtKB/Swiss-Prot:P94490" /translation="MDIADQTFVKKVNQKLLLKEILKNSPISRAKLSEMTGLNKSTVS SQVNTLMKESMVFEIGQGQSSGGRRPVMLVFNKKAGYSVGIDVGVDYINGILTDLEGT IVLDQYRHLESNSPEITKDILIDMIHHFITQMPQSPYGLIGIGICVPGLIDKDQKIVF TPNSNWRDIDLKSSIQEKYNVPVFIENEANAGAYGEKVFGAAKNHDNIIYVSISTGIG IGVIINNHLYRGVSGFSGEMGHMTIDFNGPKCSCGNRGCWELYASEKALLKSLQTKEK KLSYQDIINLAHLNDIGTLNALQNFGFYLGIGLTNILNTFNPQAVILRNSIIESHPMV LNSMRSEVSSRVYSQLGNSYELLPSSLGQNAPALGMSSIVIDHFLDMITM*" /label="xylR CDS" gene complement(1685266..1686420) /gene="xylR" /locus_tag="BSU_17590" /old_locus_tag="BSU17590" /label="xylR gene" downshifts complement(1685269) /Source="Nicolas_upshifts" /id="D952" /incds=0 /nref=9 /ntot=198 /MaxReadThrough="2.56326" /MaxDrop="4.09398" /score="19.297583" /energy="-7.4" /TU="NA" /idTUdmin="U1405" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1686319..1686497) /Source="Nicolas_S_feature" /locus_tag="new_1891565_1891743_c" /HighExp="dia15, Etha, dia5, dia0, Cold, LBGstat, Lbexp, M0t45, Diami, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S633" promotor_-35 1686465..1686471 /Source="Nicolas_upshift_promotors" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1686480..1686499) /Source="Nicolas_upshift_promotors" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1686481..1686497 /Source="Nicolas_upshift_promotors" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1686491 /Source="Nicolas_upshifts" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1686497) /Source="Nicolas_upshifts" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1686514..1686517) /Source="Nicolas_upshift_promotors" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1686524..1686531 /Source="Nicolas_upshift_promotors" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1686546..1686565 /Source="Nicolas_upshift_promotors" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1686557..1686661 /Source="Nicolas_S_feature" /locus_tag="new_1891803_1891907" /HighExp="dia15, dia0, Lbexp, dia5, B60, Sw, G150, LPhT, Mt0, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S634" upshifts 1686558 /Source="Nicolas_upshifts" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="upshifts" CDS 1686662..1687999 /gene="xylA" /locus_tag="BSU_17600" /old_locus_tag="BSU17600" /EC_number="5.3.1.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7663444, 8132469" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7663444, 8132469; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylose isomerase" /protein_id="NP_389642.2" /db_xref="EnsemblGenomes-Gn:BSU17600" /db_xref="EnsemblGenomes-Tr:CAB13644" /db_xref="GOA:P0CI80" /db_xref="InterPro:IPR001998" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR013452" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG10806" /db_xref="UniProtKB/Swiss-Prot:P0CI80" /translation="MAQSHSSSINYFGSANKVVYEGKDSTNPLAFKYYNPQEVIGGKT LKEHLRFSIAYWHTFTADGTDVFGAATMQRPWDHYKGMDLAKMRVEAAFEMFEKLDAP FFAFHDRDIAPEGSTLKETNQNLDMIMGMIKDYMRNSGVKLLWNTANMFTNPRFVHGA ATSCNADVFAYAAAQVKKGLETAKELGAENYVFWGGREGYETLLNTDLKFELDNLARF MHMAVDYAKEIGYTGQFLIEPKPKEPTTHQYDTDAATTIAFLKQYGLDNHFKLNLEAN HATLAGHTFEHELRMARVHGLLGSVDANQGHPLLGWDTDEFPTDLYSTTLAMYEILQN GGLGSGGLNFDAKVRRSSFEPDDLIYAHIAGMDAFARGLKVAHKLIEDRVFEDVIQHR YRSFTEGIGLEIIEGRANFHTLEQYALNHKSIKNESGRQEKLKAILNQYILEV*" /label="xylA CDS" gene 1686662..1687999 /gene="xylA" /locus_tag="BSU_17600" /old_locus_tag="BSU17600" /label="xylA gene" S_feature 1688000..1688074 /Source="Nicolas_S_feature" /locus_tag="new_1893246_1893320" /HighExp="dia0, dia15, Sw, Lbexp, dia5, B60, Mt0, M0t45, G150, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S635" downshifts 1688031 /Source="Nicolas_upshifts" /id="D953" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="4.89699" /MaxDrop="3.40404" /score="13.0570501" /energy="-10.2" /TU="U1406" /idTUdmin="U1406" /TUdmin="-1892" /isTUend="FALSE" /label="downshifts" CDS 1688150..1689649 /gene="xylB" /locus_tag="BSU_17610" /old_locus_tag="BSU17610" /EC_number="2.7.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1660563, 8866023, 27467131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylulose kinase" /protein_id="NP_389643.1" /db_xref="EnsemblGenomes-Gn:BSU17610" /db_xref="EnsemblGenomes-Tr:CAB13645" /db_xref="GOA:P39211" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR006000" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10807" /db_xref="UniProtKB/Swiss-Prot:P39211" /translation="MKYVIGIDLGTSAVKTILVNQNGKVCAETSKRYPLIQEKAGYSE QNPEDWVQQTIEALAELVSISNVQAKDIDGISYSGQMHGLVLLDQDRQVLRNAILWND TRTTPQCIRMTEKFGDHLLDITKNRVLEGFTLPKMLWVKEHEPELFKKTAVFLLPKDY VRFRMTGVIHTEYSDAAGTLLLHITRKEWSNDICNQIGISADICPPLVESHDCVGSLL PHVAAKTGLLEKTKVYAGGADNACGAIGAGILSSGKTLCSIGTSGVILSYEEEKERDF KGKVHFFNHGKKDSFYTMGVTLAAGYSLDWFKRTFAPNESFEQLLQGVEAIPIGANGL LYTPYLVGERTPHADSSIRGSLIGMDGAHNRKHFLRAIMEGITFSLHESIELFREAGK SVHTVVSIGGGAKNDTWLQMQADIFNTRVIKLENEQGPAMGAAMLAAFGSGWFESLEE CAEQFIREAAAFYPKAQNVQKYKTLFDLYKNIYTHTKDLNTALKSFRKN*" /label="xylB CDS" gene 1688150..1689649 /gene="xylB" /locus_tag="BSU_17610" /old_locus_tag="BSU17610" /label="xylB gene" S_feature 1689650..1689965 /Source="Nicolas_S_feature" /locus_tag="new_1894896_1895211" /HighExp="dia0, dia15, Lbexp, dia5, Mt0, M0t45, G150, Etha, Diami, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.51323200000000002" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S636" downshifts 1689923 /Source="Nicolas_upshifts" /id="D954" /incds=0 /nref=60 /ntot=197 /MaxReadThrough="0.61776" /MaxDrop="5.13425" /score="13.0570501" /energy="-10.2" /TU="NA" /idTUdmin="U1406" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1690132..1690767) /gene="yncB" /locus_tag="BSU_17620" /old_locus_tag="BSU17620" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11584000" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11584000; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA nuclease, lipoprotein (phage origin)" /protein_id="NP_389644.1" /db_xref="EnsemblGenomes-Gn:BSU17620" /db_xref="EnsemblGenomes-Tr:CAB13646" /db_xref="GOA:P94492" /db_xref="InterPro:IPR002071" /db_xref="InterPro:IPR016071" /db_xref="InterPro:IPR035437" /db_xref="SubtiList:BG12265" /db_xref="UniProtKB/Swiss-Prot:P94492" /translation="MKKILISMIAIVLSITLAACGSNHAAKNHSDSNGTEQVSQDTHS NEYNQTEQKAGTPHSKNQKKLVNVTLDRAIDGDTIKVIYNGKKDTVRYLLVDTPETKK PNSCVQPYGEDASKRNKELVNSGKLQLEFDKGDRRDKYGRLLAYVYVDGKSVQETLLK EGLARVAYVYEPNTKYIDQFRLDEQEAKSDKLSIWSKSGYVTNRGFNGCVK*" /label="yncB CDS" gene complement(1690132..1690767) /gene="yncB" /locus_tag="BSU_17620" /old_locus_tag="BSU17620" /label="yncB gene" promotor_-10 complement(1690804..1690823) /Source="Nicolas_upshift_promotors" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1690813) /Source="Nicolas_upshifts" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1690838..1690845) /Source="Nicolas_upshift_promotors" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1690955..1690962 /Source="Nicolas_upshift_promotors" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1690977..1690996 /Source="Nicolas_upshift_promotors" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1690979..1691177 /Source="Nicolas_S_feature" /locus_tag="new_1896225_1896423" /HighExp="T0.30H, Lbtran, T1.0H, M9-stat, M0t90, T1.30H, M40t90, T2.0H, T0.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S637" upshifts 1690979 /Source="Nicolas_upshifts" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="upshifts" CDS 1691178..1692593 /gene="yncC" /locus_tag="BSU_17630" /old_locus_tag="BSU17630" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22900538, 23569278; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar transporter" /protein_id="NP_389645.2" /db_xref="EnsemblGenomes-Gn:BSU17630" /db_xref="EnsemblGenomes-Tr:CAB13647" /db_xref="GOA:P94493" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12266" /db_xref="UniProtKB/Swiss-Prot:P94493" /translation="MDMNEHRNRRLKLIMISATFGGLLFGYDTGVINGALPFMARPDQ LDLTPVTEGLVTSILLLGAAFGALLCGRLADRYGRRKMILNLSFLFFLASLGTALAPN VFIMAVFRFLLGLAVGGASAMVPAFLAEMAPHEKRGRMVTQNELMIVGGQFLAYVFNA ILGVTMANTGHVWRYMLVICAVPAIMLFASMLKVPESPRWLISKGKNSEALRVLKQIR EDKRAEAECREIQEAVEKDTALEKASLKDFSTPWLRRLLWIGIGVAIVNQITGVNSIM YYGTQILKESGFGTKAALIANIGNGLISVIAVIFGIWLVGKVRRRPILLIGLAGTTTA LLLIAIFSIVLDGSMALPYVVLSLTVLFLAFMQGCVGPVTWLVIAEIFPQRLRGLGSG ISVFFLWILNFVIGFAFPILLSSVGLSFTFFIFVALGVLAIGFVYKFMPETKGRTLEE LEEHFRSRHDHNTPEQSVIEV*" /label="yncC CDS" gene 1691178..1692593 /gene="yncC" /locus_tag="BSU_17630" /old_locus_tag="BSU17630" /label="yncC gene" downshifts 1692583 /Source="Nicolas_upshifts" /id="D955" /incds=0 /nref=13 /ntot=69 /MaxReadThrough="0.90595" /MaxDrop="4.35189" /score="15.579587" /energy="-8.6" /TU="NA" /idTUdmin="U1408" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" downshifts complement(1692686) /Source="Nicolas_upshifts" /id="D956" /incds=0 /nref=13 /ntot=41 /MaxReadThrough="1.08869" /MaxDrop="5.39832" /score="24.3759796" /energy="-9.3" /TU="NA" /idTUdmin="U1409" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(1692695..1693879) /gene="alrB" /locus_tag="BSU_17640" /old_locus_tag="BSU17640" /EC_number="5.1.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10348844, 18399999" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10348844, 18399999; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alanine racemase (minor activity)" /protein_id="NP_389646.1" /db_xref="EnsemblGenomes-Gn:BSU17640" /db_xref="EnsemblGenomes-Tr:CAB13648" /db_xref="GOA:P94494" /db_xref="InterPro:IPR000821" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR011079" /db_xref="InterPro:IPR020622" /db_xref="InterPro:IPR029066" /db_xref="PDB:5IRP" /db_xref="SubtiList:BG12267" /db_xref="UniProtKB/Swiss-Prot:P94494" /translation="MIKLCREVWIEVNLDAVKKNLRAIRRHIPHKSKIMAVVKANGYG HGSIEVARHALEHGASELAVASVEEGIVLRKAGITAPILVLGFTSLSCVKKSAAWNIT LSAFQVDWMKEANEILEKEASANRLAIHINVDTGMGRLGVRTKEELLEVVKALKASKF LRWTGIFTHFSTADEPDTTLTKLQHEKFISFLSFLKKQGIELPTVHMCNTAAAIAFPE FSADMIRLGIGLYGLYPSAYIKQLNLVKLEPALSLKARIAYVKTMRTEPRTVSYGATY IAEPNEVIATLPIGYADGYSRALSNRGFVLHRGKRVPVAGRVTMDMIMVSLGENGEGK QGDEVVIYGKQKGAEISVDEVAEMLNTINYEVVSTLSRRIPRFYIRDGEIFKVSTPVL YV*" /label="alrB CDS" gene complement(1692695..1693879) /gene="alrB" /locus_tag="BSU_17640" /old_locus_tag="BSU17640" /label="alrB gene" S_feature complement(1693880..1693959) /Source="Nicolas_S_feature" /locus_tag="new_1899126_1899205_c" /HighExp="S4, S5, S3, S6, S7, B36, BT, S8, LoTm, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.908" /TUlongSig="NA" /TUlongPSig="NA" /label="S638" promotor_-10 complement(1693952..1693970) /Source="Nicolas_upshift_promotors" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1693963) /Source="Nicolas_upshifts" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1693986..1693991) /Source="Nicolas_upshift_promotors" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1694271..1694278 /Source="Nicolas_upshift_promotors" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1694293..1694312 /Source="Nicolas_upshift_promotors" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1694301 /Source="Nicolas_upshifts" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="upshifts" CDS 1694343..1694804 /gene="yncE" /locus_tag="BSU_17650" /old_locus_tag="BSU17650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative prophage protein" /protein_id="NP_389648.2" /db_xref="EnsemblGenomes-Gn:BSU17650" /db_xref="EnsemblGenomes-Tr:CAB13649" /db_xref="InterPro:IPR020216" /db_xref="SubtiList:BG12268" /db_xref="UniProtKB/Swiss-Prot:P94495" /translation="MNRGVSFQIPNEYGNFLWRILQPVEIANYRWQTSGESYFVVEGE LDDEELFHDYEIVEGAVFEQQLKTNQYYTIFVELKAFPYGKMVNQVNTYEEFADSDCE LVLLIADNSYVSIYCKNKNIIEKLYFNALQHDFEDVQFITDENDTRTSLTV*" /label="yncE CDS" gene 1694343..1694804 /gene="yncE" /locus_tag="BSU_17650" /old_locus_tag="BSU17650" /label="yncE gene" CDS 1694834..1695268 /gene="dutA" /locus_tag="BSU_17660" /old_locus_tag="BSU17660" /EC_number="3.6.1.23" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11375514, 15939294, 16908222, 17169987, 21358047, 23897460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11375514, 15939294, 16908222, 17169987, 21358047, 23897460; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="deoxyuridine 5'-triphosphate pyrophosphatase (phage origin)" /protein_id="NP_389649.1" /db_xref="EnsemblGenomes-Gn:BSU17660" /db_xref="EnsemblGenomes-Tr:CAB13650" /db_xref="GOA:O31801" /db_xref="InterPro:IPR029054" /db_xref="InterPro:IPR033704" /db_xref="InterPro:IPR036157" /db_xref="PDB:2XCD" /db_xref="PDB:2XCE" /db_xref="PDB:4AOO" /db_xref="PDB:4AOZ" /db_xref="PDB:4APZ" /db_xref="PDB:4B0H" /db_xref="SubtiList:BG13437" /db_xref="UniProtKB/Swiss-Prot:O31801" /translation="MTMQIKIKYLDETQTRISKIEQGDWIDLRAAEDVTIKKDEFKLV PLGVAMELPEGYEAHVVPRSSTYKNFGVIQTNSMGVIDESYKGDNDFWFFPAYALRDT EIKKGDRICQFRIMKKMPAVELVEVEHLGNEDRGGLGSTGTK*" /label="dutA CDS" gene 1694834..1695268 /gene="dutA" /locus_tag="BSU_17660" /old_locus_tag="BSU17660" /label="dutA gene" S_feature complement(1695017..1695322) /Source="Nicolas_S_feature" /locus_tag="new_1900263_1900568_c" /HighExp="LoTm, S5, T5.0H, S8, T4.0H, S4, S7, T3.30H, Cold, T-4.40H" /AntisenseName="yncF" /AntisenseCor="-0.40042805081531202" /AntisenseRegPval="-11.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S639" downshifts 1695115 /Source="Nicolas_upshifts" /id="D957" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="4.18195" /MaxDrop="2.2821" /score="0.171090809" /energy="-9.3" /TU="U1410" /idTUdmin="U1408" /TUdmin=2530 /isTUend="FALSE" /label="downshifts" S_feature 1695269..1696365 /Source="Nicolas_S_feature" /locus_tag="new_1900515_1901611" /HighExp="S8, G150, G180, dia0, G135, UNK1, MG 15, Lbexp, Fru, S7" /AntisenseName="cotU" /AntisenseCor="-0.266961200384908" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S640" S_feature complement(1695324..1695609) /Source="Nicolas_S_feature" /locus_tag="new_1900570_1900855_c" /HighExp="LoTm, dia5, dia15, T3.30H, T3.0H, T-4.40H, T4.0H, T5.0H, T-3.40H, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25207000000000002" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S641" downshifts complement(1695367) /Source="Nicolas_upshifts" /id="D958" /incds=0 /nref=2 /ntot=95 /MaxReadThrough="4.29622" /MaxDrop="2.9464" /score="11.6697365" /energy="-9.7" /TU="U1411" /idTUdmin="U1411" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1695604..1695623) /Source="Nicolas_upshift_promotors" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1695609) /Source="Nicolas_upshifts" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1695635..1695640) /Source="Nicolas_upshift_promotors" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1695871) /Source="Nicolas_upshifts" /id="D959" /incds=0 /nref=17 /ntot=130 /MaxReadThrough="2.07509" /MaxDrop="8.56023" /score="11.6697365" /energy="-9.7" /TU="NA" /idTUdmin="U1412" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1695871..1696131) /gene="cotU" /locus_tag="BSU_17670" /old_locus_tag="BSU17670" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12562816, 18065538, 20023017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 18065538, 20023017; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_389650.1" /db_xref="EnsemblGenomes-Gn:BSU17670" /db_xref="EnsemblGenomes-Tr:CAB13651" /db_xref="GOA:O31802" /db_xref="SubtiList:BG13471" /db_xref="UniProtKB/Swiss-Prot:O31802" /translation="MGYYKKYKEEYYTWKKTYYKKYYDNDKKHYDCDKYYDHDKKHYD YDKKYDDHDKKYYDDHDYHYEKKYYDDDDHYYDFVESYKKHH*" /label="cotU CDS" gene complement(1695871..1696131) /gene="cotU" /locus_tag="BSU_17670" /old_locus_tag="BSU17670" /label="cotU gene" promotor_-10 complement(1696152..1696171) /Source="Nicolas_upshift_promotors" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1696162) /Source="Nicolas_upshifts" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1696184..1696193) /Source="Nicolas_upshift_promotors" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1696366..1696491 /gene="ynzJ" /locus_tag="BSU_17678" /old_locus_tag="BSU17678" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein (putative phage origin)" /db_xref="PSEUDO:CAX52624.1" /translation="MNVMVKIQELYDVIFHTAFEGFRVRHQKQTAKPARNRSYKE*" /label="ynzJ CDS" gene 1696366..1696491 /gene="ynzJ" /locus_tag="BSU_17678" /old_locus_tag="BSU17678" /pseudo /label="ynzJ gene" S_feature 1696492..1696608 /Source="Nicolas_S_feature" /locus_tag="new_1901738_1901854" /HighExp="G180, G135, G150, dia0, UNK1, S8, Lbexp, C90, MG 5, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S642" CDS 1696535..1696699 /locus_tag="BSU_17679" /old_locus_tag="BSU17679" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein from phage origin" /protein_id="YP_009513957.1" /translation="MKLERIYFKESPIAHGQMTIDIEVKYNALNQKKLLEDLMCLDNF QFGIHKHLTI*" /label="conserved hypothetical protein from phage origin CDS" gene 1696535..1696699 /locus_tag="BSU_17679" /old_locus_tag="BSU17679" /label="gene" promotor_-35 1696583..1696592 /Source="Nicolas_upshift_promotors" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1696606..1696625 /Source="Nicolas_upshift_promotors" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1696610..1696920 /Source="Nicolas_S_feature" /locus_tag="new_1901856_1902166" /HighExp="S7, S6, S8, S5, BT, G/S, Pyr, G180, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.585202" /TUshortSig="SigK, SigA" /TUshortPSig="0.935, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S643" upshifts 1696610 /Source="Nicolas_upshifts" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1696901..1696908 /Source="Nicolas_upshift_promotors" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1696922..1696941 /Source="Nicolas_upshift_promotors" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1696922 /Source="Nicolas_upshifts" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="upshifts" CDS 1696973..1697812 /gene="thyA" /locus_tag="BSU_17680" /old_locus_tag="BSU17680" /EC_number="2.1.1.45" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:416889, 418407, 9648749, 10091656, 10574451" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 416889, 418407, 9648749, 10091656, 10574451; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate synthase A (phage origin)" /protein_id="NP_389651.1" /db_xref="EnsemblGenomes-Gn:BSU17680" /db_xref="EnsemblGenomes-Tr:CAB13652" /db_xref="GOA:P0CI79" /db_xref="InterPro:IPR000398" /db_xref="InterPro:IPR020940" /db_xref="InterPro:IPR023451" /db_xref="InterPro:IPR036926" /db_xref="PDB:1B02" /db_xref="PDB:1BKO" /db_xref="PDB:1BKP" /db_xref="PDB:1BSF" /db_xref="PDB:1BSP" /db_xref="SubtiList:BG11190" /db_xref="UniProtKB/Swiss-Prot:P0CI79" /translation="MTQFDKQYNSIIKDIINNGISDEEFDVRTKWDSDGTPAHTLSVI SKQMRFDNSEVPILTTKKVAWKTAIKELLWIWQLKSNDVNDLNMMGVHIWDQWKQEDG TIGHAYGFQLGKKNRSLNGEKVDQVDYLLHQLKNNPSSRRHITMLWNPDELDAMALTP CVYETQWYVKHGKLHLEVRARSNDMALGNPFNVFQYNVLQRMIAQVTGYELGEYIFNI GDCHVYTRHIDNLKIQMEREQFEAPELWINPEVKDFYDFTIDDFKLINYKHGDKLLFE VAV*" /label="thyA CDS" gene 1696973..1697812 /gene="thyA" /locus_tag="BSU_17680" /old_locus_tag="BSU17680" /label="thyA gene" promotor_-10 complement(1696995..1697014) /Source="Nicolas_upshift_promotors" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1697016) /Source="Nicolas_upshifts" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1697029..1697032) /Source="Nicolas_upshift_promotors" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1697772 /Source="Nicolas_upshifts" /id="D960" /incds=0 /nref=6 /ntot=143 /MaxReadThrough="4.34299" /MaxDrop="3.3234" /score="1.39203037" /energy="-7.7" /TU="U1410,U1414" /idTUdmin="U1413" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" downshifts complement(1697918) /Source="Nicolas_upshifts" /id="D961" /incds=0 /nref=6 /ntot=150 /MaxReadThrough="3.28185" /MaxDrop="3.73135" /score="3.23768043" /energy="-6.6" /TU="U1417" /idTUdmin="U1417" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" S_feature complement(1697919..1698225) /Source="Nicolas_S_feature" /locus_tag="new_1903165_1903471_c" /HighExp="LBGstat, Lbstat, LoTm, B60, LPhT, M9-stat, T1.30H, B36, nit, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99924299999999999" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S644" CDS complement(1697935..1698222) /locus_tag="BSU_17689" /old_locus_tag="BSU17689" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513958.1" /translation="MEHTGHSSFLQLFCLNLTLIRVEIGMKYEKTSLFGMILVIVALL ISIYFMCNTNALIPAGYDLAIHGIVISRTVMIAFTLYLVSKLGYFLLNKKD*" /label="conserved protein of unknown function CDS" gene complement(1697935..1698222) /locus_tag="BSU_17689" /old_locus_tag="BSU17689" /label="gene" downshifts complement(1697962) /Source="Nicolas_upshifts" /id="D962" /incds=0 /nref=2 /ntot=85 /MaxReadThrough="3.82042" /MaxDrop="6.47995" /score="3.23768043" /energy="-6.6" /TU="U1417" /idTUdmin="U1418" /TUdmin=308 /isTUend="FALSE" /label="downshifts" promotor_-35 1698049..1698057 /Source="Nicolas_upshift_promotors" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1698071..1698090 /Source="Nicolas_upshift_promotors" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1698073 /Source="Nicolas_upshifts" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="upshifts" S_feature 1698084..1698244 /Source="Nicolas_S_feature" /locus_tag="new_1903330_1903490" /HighExp="S8, S6, S7, BT, S5, S4, S3, Pyr, G/S, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.98" /TUlongSig="NA" /TUlongPSig="NA" /label="S645" downshifts 1698216 /Source="Nicolas_upshifts" /id="D963" /incds=0 /nref=13 /ntot=53 /MaxReadThrough="1.26429" /MaxDrop="5.75919" /score="7.35184753" /energy="-11.1" /TU="NA" /idTUdmin="U1416" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1698265..1698987) /gene="yncM" /locus_tag="BSU_17690" /old_locus_tag="BSU17690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved exported protein" /protein_id="NP_389652.2" /db_xref="EnsemblGenomes-Gn:BSU17690" /db_xref="EnsemblGenomes-Tr:CAB13653" /db_xref="GOA:O31803" /db_xref="InterPro:IPR029143" /db_xref="PDB:4HFS" /db_xref="SubtiList:BG13438" /db_xref="UniProtKB/Swiss-Prot:O31803" /translation="MVKKVLIAGAVGTAVLFGTLSSGIPGLPAADAQVAKAASELPNG IGGRVYLNSTGAVFTAKIVLPETVKNNDSVSTPYIYSGFRATSGTEADIGLQYSKQYN VWKPLMKVGSKNEETYIEGKDKFTYNKGFRPGSTVQMTIYKNLSGNTRMTLWGTNNDG YTGRIITEIQGTNIGTISKWKTLATAAVSYESQRDAIKATFSTSFNNITIDNKAVTPV VDTQDFAKVSVAGNNVTISVNK*" /label="yncM CDS" gene complement(1698265..1698987) /gene="yncM" /locus_tag="BSU_17690" /old_locus_tag="BSU17690" /label="yncM gene" downshifts complement(1698270) /Source="Nicolas_upshifts" /id="D964" /incds=0 /nref=31 /ntot=133 /MaxReadThrough="5.62856" /MaxDrop="4.3658" /score="0.425084384" /energy="-11.1" /TU="U1417" /idTUdmin="U1418" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1699012..1699031) /Source="Nicolas_upshift_promotors" /id="U1417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.51048951048951" /psig="0.994005994005994" /xcortree=503 /SigmaFactorBS="ttcaaaatgaaatattttgtcgatttatatacgtaaatccag ttccaaaATAAGGTATAATAAATGGCGaaaccactatcaaaagggggaattttggtga a" /listShort="yncM, S644" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1699020) /Source="Nicolas_upshifts" /id="U1417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.51048951048951" /psig="0.994005994005994" /xcortree=503 /SigmaFactorBS="ttcaaaatgaaatattttgtcgatttatatacgtaaatccag ttccaaaATAAGGTATAATAAATGGCGaaaccactatcaaaagggggaattttggtga a" /listShort="yncM, S644" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1699022..1699146) /Source="Nicolas_S_feature" /locus_tag="new_1904268_1904392_c" /HighExp="H2O2, dia15, S8, G180, G150, Paraq, Oxctl, LBGstat, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S646" CDS complement(1699147..1699503) /gene="ynzK" /locus_tag="BSU_17699" /old_locus_tag="BSU17699" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function (phage origin)" /protein_id="YP_003097731.1" /db_xref="EnsemblGenomes-Gn:BSU17699" /db_xref="EnsemblGenomes-Tr:CAX52625" /db_xref="GOA:C0H417" /db_xref="InterPro:IPR025621" /db_xref="UniProtKB/Swiss-Prot:C0H417" /translation="MYRNIVFYLILLCLFISVVMKSFEVIRTIANVICFIFVLLYFKD EMKTYSRKALAILSICFLFLVGICAFIILQGQTLMKRHLFFTGLETIAGILLIIVSLS ICTFILRKISNRLKRM*" /label="ynzK CDS" gene complement(1699147..1699503) /gene="ynzK" /locus_tag="BSU_17699" /old_locus_tag="BSU17699" /label="ynzK gene" promotor_-10 complement(1699527..1699546) /Source="Nicolas_upshift_promotors" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1699544) /Source="Nicolas_upshifts" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1699562..1699566) /Source="Nicolas_upshift_promotors" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1699743) /Source="Nicolas_upshifts" /id="D965" /incds=0 /nref=58 /ntot=194 /MaxReadThrough="0.902090000000001" /MaxDrop="9.00312" /score="34.0680178" /energy="-10.8" /TU="NA" /idTUdmin="U1419" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1699749..1699949) /gene="cotC" /locus_tag="BSU_17700" /old_locus_tag="BSU17700" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10788508, 11741866, 14762008, 18065538, 2821284, 19933362, 20023017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10788508, 11741866, 14762008, 18065538, 2821284, 19933362, 20023017; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_389653.2" /db_xref="EnsemblGenomes-Gn:BSU17700" /db_xref="EnsemblGenomes-Tr:CAB13654" /db_xref="GOA:P07790" /db_xref="SubtiList:BG10492" /db_xref="UniProtKB/Swiss-Prot:P07790" /translation="MGYYKKYKEEYYTVKKTYYKKYYEYDKKDYDCDYDKKYDDYDKK YYDHDKKDYDYVVEYKKHKKHY*" /label="cotC CDS" gene complement(1699749..1699949) /gene="cotC" /locus_tag="BSU_17700" /old_locus_tag="BSU17700" /label="cotC gene" downshifts 1699932 /Source="Nicolas_upshifts" /id="D966" /incds=0 /nref=14 /ntot=29 /MaxReadThrough="1.37504" /MaxDrop="5.08099" /score="-4.2739983" /energy="-8" /TU="NA" /idTUdmin="U1416" /TUdmin=1716 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1699971..1699990) /Source="Nicolas_upshift_promotors" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1699983) /Source="Nicolas_upshifts" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1700003..1700012) /Source="Nicolas_upshift_promotors" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1700124..1700312) /gene="tatAC" /locus_tag="BSU_17710" /old_locus_tag="BSU17710" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10974125, 11007775, 26239117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10974125, 11007775, 26239117; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_389654.1" /db_xref="EnsemblGenomes-Gn:BSU17710" /db_xref="EnsemblGenomes-Tr:CAB13655" /db_xref="GOA:O31804" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR006312" /db_xref="SubtiList:BG13464" /db_xref="UniProtKB/Swiss-Prot:O31804" /translation="MELSFTKILVILFVGFLVFGPDKLPALGRAAGKALSEFKQATSG LTQDIRKNDSENKEDKQM*" /label="tatAC CDS" gene complement(1700124..1700312) /gene="tatAC" /locus_tag="BSU_17710" /old_locus_tag="BSU17710" /label="tatAC gene" downshifts complement(1700140) /Source="Nicolas_upshifts" /id="D967" /incds=0 /nref=213 /ntot=254 /MaxReadThrough="3.38696" /MaxDrop="6.07983" /score="8.58114058" /energy="-11" /TU="U1420,U1421" /idTUdmin="U1420" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" misc_feature complement(1700281..1700288) /Source="Nicolas_upshift_promotors" /id="U1420" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.405594405594406" /xcortree=1585 /SigmaFactorBS="aatttgtttaaaaggttgtacttcaatcagggggaaaaggat atggaattaagcttcacaaaaataCTCGTTATtttgtttgtgggttttttagtatttg g" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1700294) /Source="Nicolas_upshifts" /id="U1420" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.405594405594406" /xcortree=1585 /SigmaFactorBS="aatttgtttaaaaggttgtacttcaatcagggggaaaaggat atggaattaagcttcacaaaaataCTCGTTATtttgtttgtgggttttttagtatttg g" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1700341..1700360) /Source="Nicolas_upshift_promotors" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1700359) /Source="Nicolas_upshifts" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1700375..1700382) /Source="Nicolas_upshift_promotors" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1700391..1700528 /locus_tag="BSU_17715" /old_locus_tag="BSU17715" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513959.1" /translation="MNILKPAQRRIHKTAAAEYNVQCHLPKKQEAGWINYVALPEMIQ T*" /label="hypothetical protein CDS" gene 1700391..1700528 /locus_tag="BSU_17715" /old_locus_tag="BSU17715" /label="gene" promotor_-35 1700422..1700427 /Source="Nicolas_upshift_promotors" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1700442..1700460 /Source="Nicolas_upshift_promotors" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1700460..1700562 /Source="Nicolas_S_feature" /locus_tag="new_1905706_1905808" /HighExp="S3, S4, LoTm, BT, B36, S5, S7, S6, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.35884500000000003" /TUshortSig="SigEF" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S647" upshifts 1700460 /Source="Nicolas_upshifts" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="upshifts" CDS 1700563..1700961 /gene="yndA" /locus_tag="BSU_17720" /old_locus_tag="BSU17720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="putative exported protein of unknown function" /protein_id="NP_389655.1" /db_xref="EnsemblGenomes-Gn:BSU17720" /db_xref="EnsemblGenomes-Tr:CAB13656" /db_xref="SubtiList:BG13439" /db_xref="UniProtKB/Swiss-Prot:O31805" /translation="MRFTKVVGFLSVLGLAAVFPLTAQAEKAGTAGAGEWDKLGTYTY TYSSPTVYSTGGDFRVCLSGSTPFSVSLHLYEDDPGDNPDDYVGANYFSPGECHTFGS IGKFVDGSNNKAEFFVTDYSGKSKTVTFYD*" /label="yndA CDS" gene 1700563..1700961 /gene="yndA" /locus_tag="BSU_17720" /old_locus_tag="BSU17720" /label="yndA gene" S_feature 1700962..1701766 /Source="Nicolas_S_feature" /locus_tag="new_1906208_1907012" /HighExp="LoTm, S3, BT, S4, B36, S6, S5, S7, S8, T5.0H" /AntisenseName="yndB" /AntisenseCor="-0.559713635360228" /AntisenseRegPval="-22.9" /CDS_PredictionProba="0.91098199999999996" /TUshortSig="SigEF" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S648" CDS complement(1701026..1701460) /gene="flvS" /locus_tag="BSU_17730" /old_locus_tag="BSU17730" /experiment="publication(s) with functional evidences, PMID:20818668, 28160315" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20818668, 28160315; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of stress-related ATPase (flavonoid-sensing)" /protein_id="NP_389656.1" /db_xref="EnsemblGenomes-Gn:BSU17730" /db_xref="EnsemblGenomes-Tr:CAB13657" /db_xref="GOA:O31806" /db_xref="InterPro:IPR013538" /db_xref="InterPro:IPR023393" /db_xref="PDB:2KEW" /db_xref="PDB:2KTE" /db_xref="SubtiList:BG13440" /db_xref="UniProtKB/Swiss-Prot:O31806" /translation="MAQNNENALPDITKSITLEAPIQKVWETVSTSEGIAKWFMPNDF QLKEGQEFHLQSPFGPSPCKVLAVQAPTELSFEWDTEGWVVTFQLEDLGEKTGFTLIH SGWKEPNEVIGKANEKSSVVRGKMDGGWTGIVNERLRKAVEE*" /label="flvS CDS" gene complement(1701026..1701460) /gene="flvS" /locus_tag="BSU_17730" /old_locus_tag="BSU17730" /label="flvS gene" downshifts complement(1701042) /Source="Nicolas_upshifts" /id="D968" /incds=0 /nref=213 /ntot=253 /MaxReadThrough="1.7995" /MaxDrop="6.63594" /score="29.1580701" /energy="-7" /TU="NA" /idTUdmin="U1423" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1701490..1701509) /Source="Nicolas_upshift_promotors" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1701506) /Source="Nicolas_upshifts" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1701523..1701530) /Source="Nicolas_upshift_promotors" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1701767..1701955 /gene="ynzB" /locus_tag="BSU_17740" /old_locus_tag="BSU17740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23625846" /codon_start=1 /transl_table=11 /product="conserved protein involved in spore germination" /protein_id="NP_389657.2" /db_xref="EnsemblGenomes-Gn:BSU17740" /db_xref="EnsemblGenomes-Tr:CAB13658" /db_xref="SubtiList:BG13465" /db_xref="UniProtKB/Swiss-Prot:O31807" /translation="MLGKIKAAIDNSPGKPARILVSEKAFQQLEEEMRFVYVSKPKTI MGIPVEVSDQAESFKLEF*" /label="ynzB CDS" gene 1701767..1701955 /gene="ynzB" /locus_tag="BSU_17740" /old_locus_tag="BSU17740" /label="ynzB gene" S_feature 1701956..1702041 /Source="Nicolas_S_feature" /locus_tag="new_1907202_1907287" /HighExp="LoTm, BT, S4, S6, S3, S8, S7, B36, S5, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S649" downshifts 1702000 /Source="Nicolas_upshifts" /id="D969" /incds=0 /nref=7 /ntot=89 /MaxReadThrough="2.20002" /MaxDrop="4.21414" /score="19.5879917" /energy="-11.9" /TU="NA" /idTUdmin="U1422" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1702070..1702076 /Source="Nicolas_upshift_promotors" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1702088..1702247 /Source="Nicolas_S_feature" /locus_tag="new_1907334_1907493" /HighExp="S8, S4, S6, S7, S5, S3, BT, ferm, LoTm, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.95681300000000002" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S650" upshifts 1702088 /Source="Nicolas_upshifts" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1702090..1702101 /Source="Nicolas_upshift_promotors" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1702248..1703810 /gene="yndD" /locus_tag="BSU_17750" /old_locus_tag="BSU17750" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10762253, 27208128; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_389658.1" /db_xref="EnsemblGenomes-Gn:BSU17750" /db_xref="EnsemblGenomes-Tr:CAB13659" /db_xref="GOA:O31808" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG13441" /db_xref="UniProtKB/Swiss-Prot:O31808" /translation="MMRWRNNQYKTQKQHKSDYSTAEKQDQDVLTGNIGYDLEHVKRK IGHNGDVHFRELEITQLHVKAALIFVEGLSDQDLINKGLSVLVMNQPNQVSDEISQSG KGILTSKQIKNQIVSIGDVIDSEKISDIVLNVFMGSTALLIDGIPQAFLLGTVKKQNR SIEEPLSEALVRGPRTGFTEELSTNTALLRQQGKNDQLTLQRFEVGTRLKKDLIIAYM NDIADPKVVEEVRKRVRGIEIDHLPESGYVEQLIEDNYLSPFPQVQSTERPDRVISGL MEGRVAILLDGTPFALIVPVTFSMMLQSPEDYYERWFPSSLIRLLRFIAAMITLFAPA LYISFISFHPGLIPTKLAISISGTRQGVPFPSLIEALFMEVAIEILREAGLRLPKPIG PAIGIVGGLIIGEAAVQAGIVSPIMVIVVALTAISSFAIPHYSTGIALRMLRFGAMFC AAVFGLFGVIMYYLLLSSHVVKLKSFGVPYASPAVPYHLKDWKDFVIRMPLLVMKRRP KMMNTDNTKRVK*" /label="yndD CDS" gene 1702248..1703810 /gene="yndD" /locus_tag="BSU_17750" /old_locus_tag="BSU17750" /label="yndD gene" promotor_-10 complement(1702551..1702570) /Source="Nicolas_upshift_promotors" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1702560) /Source="Nicolas_upshifts" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1702585..1702592) /Source="Nicolas_upshift_promotors" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1703840..1704931 /gene="yndE" /locus_tag="BSU_17760" /old_locus_tag="BSU17760" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative spore germination integral inner membrane protein" /protein_id="NP_389659.1" /db_xref="EnsemblGenomes-Gn:BSU17760" /db_xref="EnsemblGenomes-Tr:CAB13660" /db_xref="GOA:O31809" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG13442" /db_xref="UniProtKB/Swiss-Prot:O31809" /translation="MFSPTSKITTAQATIIIINYMLAAGVLTLPRTVTEQTQSPDGWI SVLLGGVLAVIAGMIIAKLSQQYPKETFYEYSRHIVGKWLGHLISIVFITYFLALGAF EVRVMSEIVDFFLLEGTPSWAIIMTVLWIGLYSITQGLDPIARLFEMIFPITVIIFLT IALMSLGIFEINNLRPVLGDGIMPVLRGVKTTNLSFTCSEIMFILVAFMKKPKNAVKA VVIGTGVVTSFYMITMIMVIGALSVEGVVTRTWPGLDLMRSFEIPGLIFERFESFLLV IWIMQLFATFIITFYAASLGVSQVFKKKPLSCMFGLLPVIYILSCMPKNENDVFILGD TVSHIALYIFGALPILLLVISKWRKRGEK*" /label="yndE CDS" gene 1703840..1704931 /gene="yndE" /locus_tag="BSU_17760" /old_locus_tag="BSU17760" /label="yndE gene" CDS 1704921..1706135 /gene="yndF" /locus_tag="BSU_17770" /old_locus_tag="BSU17770" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 27208128; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative spore germination lipoprotein" /protein_id="NP_389660.1" /db_xref="EnsemblGenomes-Gn:BSU17770" /db_xref="EnsemblGenomes-Tr:CAB13661" /db_xref="GOA:O31810" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG13443" /db_xref="UniProtKB/Swiss-Prot:O31810" /translation="MKSKLKRQLPAMVIVCLLMICVTGCWSSREIEDLGLTFAIAIDK GKETNTEKELKEEGGSYPKKDNITLTYQFVNEKAAGAGTSGGGGSGQGAQKAYINISE TGDSLQQIGSEVALRRDREVFSPHLKVVVMSEDVLHTFPIDEMLDQFFRDNEIRLSCL VLSAKGEARDALQLKENGEIPAFRLIGLGENEHKVSRILPPMTLAKLIGKLHSGSSFL LQNVVAANGAVKYSGAAVINGKSKKMIGTLNEYETEGITWIRGEGKGGVVKSHDKKSQ QTLAYDINKIKSRIQPIVKGKDISFHVDIESEGDLVENWNTKEALDTQFIDRLETTIE NEVKKIVGQVLKKIQHDYKADVAGFDESFRLTYPHLWKRVKNNWDDTFSKADITYSVN VTITHFGTVKTQ*" /label="yndF CDS" gene 1704921..1706135 /gene="yndF" /locus_tag="BSU_17770" /old_locus_tag="BSU17770" /label="yndF gene" promotor_-35 1706213..1706220 /Source="Nicolas_upshift_promotors" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1706235..1706254 /Source="Nicolas_upshift_promotors" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1706246 /Source="Nicolas_upshifts" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="upshifts" CDS 1706282..1707088 /gene="yndG" /locus_tag="BSU_17780" /old_locus_tag="BSU17780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11737947, 22333191, 27435445" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389661.1" /db_xref="EnsemblGenomes-Gn:BSU17780" /db_xref="EnsemblGenomes-Tr:CAB13662" /db_xref="GOA:O31811" /db_xref="SubtiList:BG13444" /db_xref="UniProtKB/Swiss-Prot:O31811" /translation="MRQKPIYVEIEMKSDLDTLWEYTQNPSLHKEWDLRFSNITYLNS QPCEKQKFLYETRVGFGLKVSGTGETVGVFNKCSSERSSSLAFGSDHPLSLIRHGSGY WKYIQRENGKMTFLTQYQYKTAYGLLGRWIDRLLFRPLLGWATAWSFDALRLWVEQNK HPKRFIRSAIIYVFMCLFFSLFWFYQGFAGVKTSILTGTAEIGLAILWLLPLKRKWII HGVQACIFAGFACLGSEIFMWVLLSVFSAASGALSLQLPSARRTKRKRKK*" /label="yndG CDS" gene 1706282..1707088 /gene="yndG" /locus_tag="BSU_17780" /old_locus_tag="BSU17780" /label="yndG gene" S_feature complement(1706896..1707994) /Source="Nicolas_S_feature" /locus_tag="new_1912142_1913240_c" /HighExp="S8, S6, S7, S5, T0.30H, T2.0H, GM 150, BT, T1.30H, T-4.40H" /AntisenseName="yndH" /AntisenseCor="-0.58089150558713998" /AntisenseRegPval="-24.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S651" CDS 1707093..1707710 /gene="yndH" /locus_tag="BSU_17790" /old_locus_tag="BSU17790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389662.1" /db_xref="EnsemblGenomes-Gn:BSU17790" /db_xref="EnsemblGenomes-Tr:CAB13663" /db_xref="InterPro:IPR025311" /db_xref="SubtiList:BG13445" /db_xref="UniProtKB/Swiss-Prot:O31812" /translation="MSSIYEKSIINYHLLHPKLQKRYQLDGSHTFSGTGTMSEISGGS FLVRMLLKLGVFFRCFFSERGKDIPFTIQNRTCLLKSQHTGIEWNRTFFFKGKKRFFD ALMIYDEKENRILDFFGKPHLLLSVLTFEASLDGSLTITSGKQWLLICGKRIPLPKWL TGTSEVCETFDEKKNCFTIEVHVQNTILGTLFFYKGTFQEEERES*" /label="yndH CDS" gene 1707093..1707710 /gene="yndH" /locus_tag="BSU_17790" /old_locus_tag="BSU17790" /label="yndH gene" CDS 1707707..1709347 /gene="yndJ" /locus_tag="BSU_17800" /old_locus_tag="BSU17800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12618455, 15849754, 16850406, 28615734; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389663.1" /db_xref="EnsemblGenomes-Gn:BSU17800" /db_xref="EnsemblGenomes-Tr:CAB13664" /db_xref="GOA:O31813" /db_xref="InterPro:IPR025450" /db_xref="SubtiList:BG13446" /db_xref="UniProtKB/Swiss-Prot:O31813" /translation="MKRNGIVSALCFIGFLAAEAPDISVAEALVLLSILFFVPGIFPF VFRQSPVRAAQFMENGLIQCYPVAAFFAVLALVTEVGGFALIWWMYTVFNALYAILRL WETKIHRIEETSVLFGLIYLAGGGFWFFAYAAHLQIMQFGPLIILLTAVHFHYSAFLI PIFNGLLGRTIRKHRMLYSWITWVILLSPLLIALGITYSKTLDVIAVSIYMAAIYLHA FLVFTAAFRTKTGTFLIRLSSAVLMITIAFSMIYSFGVFRQEVTLTINQMIWIHGFVN AFGVILPALIGWRIEDAKPFDADSVKTFSRIYGKRKIGEEFLANIQAENNARYSGLVD DMGSLRSKDFSPEKLAPLILSFYEQTIEYNIKAKVTWSTWFRPLAIIYEWFSRRIGQI HLSTNPDWYRMYSKIKGVHSKKDGRERVRAWIRTNEKNETIFTALYSVYRSNGEGYMN ISLPLPFSSMTGILKPYHHQEKLVLTSRRRKSRAGDEGIYLQTRAGTCPLPLSETFLI EAVHDNKLTAVHHMWLFGIKFLTVHYSITHINQPIERT*" /label="yndJ CDS" gene 1707707..1709347 /gene="yndJ" /locus_tag="BSU_17800" /old_locus_tag="BSU17800" /label="yndJ gene" promotor_-10 complement(1707981..1708000) /Source="Nicolas_upshift_promotors" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1707994) /Source="Nicolas_upshifts" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1708014..1708022) /Source="Nicolas_upshift_promotors" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1708987..1709753) /Source="Nicolas_S_feature" /locus_tag="new_1914233_1914999_c" /HighExp="T2.0H, T1.30H, T2.30H, GM 150, T3.30H, T1.0H, C30, T3.0H, T4.0H, T0.30H" /AntisenseName="yndK" /AntisenseCor="-0.33555507319526101" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S652" CDS 1709384..1709749 /gene="yndK" /locus_tag="BSU_17810" /old_locus_tag="BSU17810" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage/plasmid replication protein" /protein_id="NP_389664.1" /db_xref="EnsemblGenomes-Gn:BSU17810" /db_xref="EnsemblGenomes-Tr:CAB13665" /db_xref="GOA:O31814" /db_xref="SubtiList:BG13447" /db_xref="UniProtKB/Swiss-Prot:O31814" /translation="MNCFKILHRIKTGKEGFMVFYISLFLILWLAAGFAVGMKQVYVD QLFDKAVIERLEKEANDHGHADRMIKQRVLYIAAVTVSGFISVYYEMKTIPQRRNIRK IEKNIMKLNQAKKRRMKRK*" /label="yndK CDS" gene 1709384..1709749 /gene="yndK" /locus_tag="BSU_17810" /old_locus_tag="BSU17810" /label="yndK gene" downshifts 1709726 /Source="Nicolas_upshifts" /id="D970" /incds=0 /nref=166 /ntot=243 /MaxReadThrough="2.62352" /MaxDrop="5.68917" /score="15.340233" /energy="-10.4" /TU="NA" /idTUdmin="U1426" /TUdmin=2226 /isTUend="FALSE" /label="downshifts" misc_RNA complement(1709746..1710026) /gene="surA" /locus_tag="BSU_misc_RNA_72" /product="small untranslated RNA controlled by sporulation" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" /label="surA RNA" gene complement(1709746..1710026) /gene="surA" /locus_tag="BSU_misc_RNA_72" /label="surA gene" S_feature complement(1709755..1709886) /Source="Nicolas_S_feature" /locus_tag="new_1915001_1915132_c" /HighExp="B60, T2.0H, T1.30H, T1.0H, T2.30H, M9-stat, LoTm, S5, T3.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.443, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S653" downshifts complement(1709798) /Source="Nicolas_upshifts" /id="D971" /incds=0 /nref=21 /ntot=129 /MaxReadThrough="4.91485" /MaxDrop="4.94426" /score="14.7738511" /energy="-10.4" /TU="U1429,U1431" /idTUdmin="U1429" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 1709846..1709855 /Source="Nicolas_upshift_promotors" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1709868..1709877) /Source="Nicolas_upshift_promotors" /id="U1429" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.442557442557443" /psig="0.442557442557443" /xcortree=1043 /SigmaFactorBS="gaatgtaggtctctttgaggctttagcacgaattctctcgtc ctccttgttaaatttttgttaaattcaCAATATTATAtaccattagcccgggcgctgt t" /listShort="S653" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1709869..1709888 /Source="Nicolas_upshift_promotors" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1709874 /Source="Nicolas_upshifts" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="upshifts" S_feature 1709876..1709974 /Source="Nicolas_S_feature" /locus_tag="new_1915122_1915220" /HighExp="S8, S6, S7, BT, S5, G/S, B36, C30, Pyr, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52117199999999997" /TUshortSig="SigK" /TUshortPSig="0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S654" upshifts complement(1709886) /Source="Nicolas_upshifts" /id="U1429" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.442557442557443" /psig="0.442557442557443" /xcortree=1043 /SigmaFactorBS="gaatgtaggtctctttgaggctttagcacgaattctctcgtc ctccttgttaaatttttgttaaattcaCAATATTATAtaccattagcccgggcgctgt t" /listShort="S653" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1709888..1710018) /Source="Nicolas_S_feature" /locus_tag="new_1915134_1915264_c" /HighExp="T2.0H, T1.30H, M9-stat, T2.30H, T1.0H, B60, LoTm, T4.0H, T3.30H, T0.30H" /AntisenseName="yndL" /AntisenseCor="0.22331158442510801" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S655" CDS 1709975..1710733 /gene="pghL" /locus_tag="BSU_17820" /old_locus_tag="BSU17820" /EC_number="3.4.19.-" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:26158264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26158264; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage gamma-polyglutamate hydrolase" /protein_id="NP_389665.1" /db_xref="EnsemblGenomes-Gn:BSU17820" /db_xref="EnsemblGenomes-Tr:CAB13666" /db_xref="GOA:O31815" /db_xref="InterPro:IPR008585" /db_xref="SubtiList:BG13448" /db_xref="UniProtKB/Swiss-Prot:O31815" /translation="MKPAKVSLLRRLLHSLKHVDCNIAKRFPSTIKIVKLLMIFMVFT PISSIYAEDVYQNFEELKNNEDPSDYGVVTKETGSPVLVLAIHGGGIEGGTSEVAREL SKEYSMYLFEGLKSAGNSVLHITSTHFDEPRALKMTGNHEYVISLHGYAEEDQQIEVG GTDRVRAADLVEKLQHAGFPAVLLNMDHPHAGVSPNNIANKSKTGLSIQIEMSTGFRK SLFGIFSLKSRAVTQNERFYEFTEVMFRFLKNSY*" /label="pghL CDS" gene 1709975..1710733 /gene="pghL" /locus_tag="BSU_17820" /old_locus_tag="BSU17820" /label="pghL gene" upshifts 1710008 /Source="Nicolas_upshifts" /id="U1430" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.211788211788212" /xcortree=1323 /SigmaFactorBS="gttgatttggacttagaggcggagtagatgaaaccggccaaa gtatccctgctCcGccgtttgctccattccttgaagcatgttgattgtaacatagcca a" /listShort="yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1710024..1710043) /Source="Nicolas_upshift_promotors" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1710025) /Source="Nicolas_upshifts" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1710058..1710065) /Source="Nicolas_upshift_promotors" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1710548..1710759) /Source="Nicolas_S_feature" /locus_tag="new_1915794_1916005_c" /HighExp="S8, S5, S7, S6, S4, ferm, nit, BT, Pyr, G/S" /AntisenseName="yndL" /AntisenseCor="0.82198535504067005" /AntisenseRegPval="-66.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.515" /TUlongSig="NA" /TUlongPSig="NA" /label="S656" downshifts 1710712 /Source="Nicolas_upshifts" /id="D972" /incds=0 /nref=3 /ntot=23 /MaxReadThrough="4.17889" /MaxDrop="5.0493" /score="15.340233" /energy="-10.4" /TU="U1428,U1430" /idTUdmin="U1428" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" S_feature 1710757..1711376 /Source="Nicolas_S_feature" /locus_tag="new_1916003_1916622" /HighExp="S8, S6, S7, S5, C30, BT, G135, LBGstat, GM 150, M/G" /AntisenseName="yndM" /AntisenseCor="0.75549671487088998" /AntisenseRegPval="-50.2" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S657" CDS complement(1710760..1711299) /gene="yndM" /locus_tag="BSU_17830" /old_locus_tag="BSU17830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389666.1" /db_xref="EnsemblGenomes-Gn:BSU17830" /db_xref="EnsemblGenomes-Tr:CAB13667" /db_xref="GOA:O31816" /db_xref="InterPro:IPR019649" /db_xref="SubtiList:BG13449" /db_xref="UniProtKB/Swiss-Prot:O31816" /translation="MTIMNGFELHYLSFVYAQEFSSKNNNLGGQMKHIIALASKIAFT LALLYVILDRVYHASFLSVMFIALFLGFVSYLSGDMLVLPRTNNITASLADFGLSFVI LWVFVLTQTRNDFSPFGAALLSAACLTVFEYFFHRYLLKNVLDENFRNELSARDNTLQ YQTEAADELFPETKEKHKE*" /label="yndM CDS" gene complement(1710760..1711299) /gene="yndM" /locus_tag="BSU_17830" /old_locus_tag="BSU17830" /label="yndM gene" promotor_-10 complement(1711300..1711314) /Source="Nicolas_upshift_promotors" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1711306) /Source="Nicolas_upshifts" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1711328..1711334) /Source="Nicolas_upshift_promotors" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1711354..1711363 /Source="Nicolas_upshift_promotors" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1711376..1711391 /Source="Nicolas_upshift_promotors" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1711378 /Source="Nicolas_upshifts" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="upshifts" CDS 1711417..1711851 /gene="fosB" /locus_tag="BSU_17840" /old_locus_tag="BSU17840" /EC_number="2.5.1.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11244082, 16399398, 19763274, 23256780" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11244082, 16399398, 19763274, 23256780; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="magnesium-dependent bacillithiol-transferase" /protein_id="NP_389667.1" /db_xref="EnsemblGenomes-Gn:BSU17840" /db_xref="EnsemblGenomes-Tr:CAB13668" /db_xref="GOA:O31817" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR022858" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13450" /db_xref="UniProtKB/Swiss-Prot:O31817" /translation="MEIKGINHLLFSVSHLDTSIDFYQKVFGAKLLVKGRTTAYFDMN GIWLALNEEPDIPRNDIKLSYTHIAFTIEDHEFEEMSAKLKRLHVNILPGRERDERDR KSIYFTDPDGHKFEFHTGTLQDRLRYYKQEKTHMHFYDETAF*" /label="fosB CDS" gene 1711417..1711851 /gene="fosB" /locus_tag="BSU_17840" /old_locus_tag="BSU17840" /label="fosB gene" CDS 1711709..1712056 /gene="yzzP" /locus_tag="BSU_17845" /old_locus_tag="BSU17845" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27144405" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513960.1" /translation="MNAIENQFILPTLTATNLNFIPEPFKTGFDITNKKKRICTFMMK RPFDSTTIFHIRLNLKKGVGGDFMFGEGFYPTCSTMPYLLNCTSDWVKVKLKYTLHYI LYEESELFYQMLN*" /label="yzzP CDS" gene 1711709..1712056 /gene="yzzP" /locus_tag="BSU_17845" /old_locus_tag="BSU17845" /label="yzzP gene" S_feature 1711852..1712184 /Source="Nicolas_S_feature" /locus_tag="new_1917098_1917430" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T-0.40H, T0.0H, T-1.10H, T2.30H, Salt, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.66836499999999999" /TUshortSig="SigWXY, Sig-, SigK" /TUshortPSig="1, 0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S658" promotor_-35 1712143..1712152 /Source="Nicolas_upshift_promotors" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1712164..1712179 /Source="Nicolas_upshift_promotors" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1712186..1712364 /Source="Nicolas_S_feature" /locus_tag="new_1917432_1917610" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T-0.40H, T-1.10H, T0.0H, T2.30H, T3.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigWXY, Sig-, SigK" /TUshortPSig="0.99, 1, 0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S659" upshifts 1712186 /Source="Nicolas_upshifts" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1712255..1712334 /gene="ncrF" /locus_tag="BSU_misc_RNA_73" /product="putative conserved small untranslated RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="ncrF RNA" gene 1712255..1712334 /gene="ncrF" /locus_tag="BSU_misc_RNA_73" /label="ncrF gene" downshifts 1712321 /Source="Nicolas_upshifts" /id="D973" /incds=0 /nref=16 /ntot=188 /MaxReadThrough="2.99425" /MaxDrop="4.30173" /score="-1.31226475" /energy="-14.3" /TU="U1433" /idTUdmin="U1434" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(1712393..1713010) /gene="lexA" /locus_tag="BSU_17850" /old_locus_tag="BSU17850" /function="16.8: Protect" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14652736, 16267290, 16269821, 16855250, 17042786, 19684115, 24285298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652736, 16267290, 16269821, 16855250, 17042786, 19684115, 24285298; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the SOS regulon" /protein_id="NP_389668.1" /db_xref="EnsemblGenomes-Gn:BSU17850" /db_xref="EnsemblGenomes-Tr:CAB13669" /db_xref="GOA:P31080" /db_xref="InterPro:IPR006197" /db_xref="InterPro:IPR006199" /db_xref="InterPro:IPR006200" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR036286" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10678" /db_xref="UniProtKB/Swiss-Prot:P31080" /translation="MTKLSKRQLDILRFIKAEVKSKGYPPSVREIGEAVGLASSSTVH GHLARLETKGLIRRDPTKPRAIEILDEEVDIPQSQVVNVPVIGKVTAGSPITAVENIE EYFPLPDRMVPPDEHVFMLEIMGDSMIDAGILDKDYVIVKQQNTANNGEIVVAMTEDD EATVKRFYKEDTHIRLQPENPTMEPIILQNVSILGKVIGVFRTVH*" /label="lexA CDS" gene complement(1712393..1713010) /gene="lexA" /locus_tag="BSU_17850" /old_locus_tag="BSU17850" /label="lexA gene" downshifts complement(1712394) /Source="Nicolas_upshifts" /id="D974" /incds=0 /nref=186 /ntot=254 /MaxReadThrough="2.74616" /MaxDrop="7.90985" /score="8.16083322" /energy="-16.3" /TU="U1435" /idTUdmin="U1435" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1713034..1713053) /Source="Nicolas_upshift_promotors" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1713055) /Source="Nicolas_upshifts" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1713067..1713074) /Source="Nicolas_upshift_promotors" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1713090..1713097 /Source="Nicolas_upshift_promotors" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1713109 /Source="Nicolas_upshifts" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1713111..1713130 /Source="Nicolas_upshift_promotors" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1713160..1713477 /gene="dinK" /locus_tag="BSU_17860" /old_locus_tag="BSU17860" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12581363, 16267290, 16549676, 20400548, 20807205, 23728628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12581363, 16267290, 16549676, 20400548, 20807205, 23728628; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell division inhibitor" /protein_id="NP_389669.1" /db_xref="EnsemblGenomes-Gn:BSU17860" /db_xref="EnsemblGenomes-Tr:CAB13670" /db_xref="GOA:Q45056" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR022887" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11820" /db_xref="UniProtKB/Swiss-Prot:Q45056" /translation="MIMSKESIIFVGLFTVILSAVILMLSYTSSGQELNQYVKIEVQQ GDTLWSIADQVADTKKINKNDFIEWVADKNQLQTSDIQPGDELVIPLKKKHQDAYELA TVR*" /label="dinK CDS" gene 1713160..1713477 /gene="dinK" /locus_tag="BSU_17860" /old_locus_tag="BSU17860" /label="dinK gene" promotor_-10 complement(1713177..1713195) /Source="Nicolas_upshift_promotors" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1713180) /Source="Nicolas_upshifts" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1713209..1713216) /Source="Nicolas_upshift_promotors" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1713496..1714149 /gene="dinL" /locus_tag="BSU_17870" /old_locus_tag="BSU17870" /function="16.9: Replicate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12581363, 16267290, 17020588, 19060143, 22933559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative site-specific recombinase, resolvase" /protein_id="NP_389670.1" /db_xref="EnsemblGenomes-Gn:BSU17870" /db_xref="EnsemblGenomes-Tr:CAB13671" /db_xref="GOA:Q45057" /db_xref="InterPro:IPR006119" /db_xref="InterPro:IPR036162" /db_xref="SubtiList:BG11821" /db_xref="UniProtKB/Swiss-Prot:Q45057" /translation="MKALIYARVSTNKEQQETSLKRQEEELTAIAAENGMEVVKVISE KASGYEMDRDGVFELLDEIKNADIDVILVQDETRLGRGNAKIALLHCIYREGVKVYTT AHRGELELSEADSMVLEIVSIVEEYQRKIHNMKIRRGMKRAVKNGFKPQKNLKNQHGN SGKEKIEVPISEIVRLRANKLTFAEIAATLRGFGYDVSKATVHRRFQEYIENEETAE* " /label="dinL CDS" gene 1713496..1714149 /gene="dinL" /locus_tag="BSU_17870" /old_locus_tag="BSU17870" /label="dinL gene" promotor_-35 1714152..1714159 /Source="Nicolas_upshift_promotors" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="promotor_-35" promotor_-10 1714173..1714192 /Source="Nicolas_upshift_promotors" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="promotor_-10" upshifts 1714186 /Source="Nicolas_upshifts" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="upshifts" CDS 1714213..1714446 /gene="ynzC" /locus_tag="BSU_17880" /old_locus_tag="BSU17880" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12581363, 16267290, 18431750,19306341, 22333191, 22933559, 23099262" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389671.1" /db_xref="EnsemblGenomes-Gn:BSU17880" /db_xref="EnsemblGenomes-Tr:CAB13672" /db_xref="GOA:O31818" /db_xref="InterPro:IPR009242" /db_xref="PDB:2HEP" /db_xref="PDB:2JVD" /db_xref="PDB:3BHP" /db_xref="SubtiList:BG13466" /db_xref="UniProtKB/Swiss-Prot:O31818" /translation="MISNAKIARINELAAKAKAGVITEEEKAEQQKLRQEYLKGFRSS MKNTLKSVKIIDPEGNDVTPEKLKREQRNNKLH*" /label="ynzC CDS" gene 1714213..1714446 /gene="ynzC" /locus_tag="BSU_17880" /old_locus_tag="BSU17880" /label="ynzC gene" S_feature 1714447..1714582 /Source="Nicolas_S_feature" /locus_tag="new_1919693_1919828" /HighExp="M40t90, M40t45, dia15, C90, Etha, H2O2, T5.0H, Salt, dia5, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S660" promotor_-35 1714550..1714557 /Source="Nicolas_upshift_promotors" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="promotor_-35" promotor_-10 1714571..1714590 /Source="Nicolas_upshift_promotors" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="promotor_-10" upshifts 1714584 /Source="Nicolas_upshifts" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="upshifts" CDS 1714615..1716618 /gene="tktA" /locus_tag="BSU_17890" /old_locus_tag="BSU17890" /EC_number="2.2.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9696621, 12682299, 12882400, 27739585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696621, 12682299, 12882400, 27739585; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transketolase" /protein_id="NP_389672.1" /db_xref="EnsemblGenomes-Gn:BSU17890" /db_xref="EnsemblGenomes-Tr:CAB13673" /db_xref="GOA:P45694" /db_xref="InterPro:IPR005474" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR005478" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR020826" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033247" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG11247" /db_xref="UniProtKB/Swiss-Prot:P45694" /translation="MDTIEKKSVATIRTLSIDAIEKANSGHPGMPMGAAPMAYTLWTK FMNVSPANPGWFNRDRFVLSAGHGSALLYSMLHLSGFDLSIEDLKGFRQWGSKTPGHP EFGHTAGVDATTGPLGQGIAMAVGMAIAERHLAETYNRDSFNVVDHYTYSICGDGDLM EGISSEAASLAGHLQLGRLIVLYDSNDISLDGDLDRSFSENVKQRFEAMNWEVLYVED GNNIEELTAAIEKARQNEKKPTLIEVKTTIGFGSPNRAGTSGVHGAPLGKEESKLTKE AYAWTYEEDFYVPSEVYEHFAVAVKESGEKKEQEWNAQFAKYKEVYPELAEQLELAIK GELPKDWDQEVPVYEKGSSLASRASSGEVLNGLAKKIPFFVGGSADLAGSNKTTIKNA GDFTAVDYSGKNFWFGVREFAMGAALNGMALHGGLRVFGGTFFVFSDYLRPAIRLAAL MGLPVTYVFTHDSIAVGEDGPTHEPVEQLASLRAMPNLSLIRPADGNETAAAWKLAVQ STDHPTALVLTRQNLPTIDQTSEEALAGVEKGAYVVSKSKNETPDALLIASGSEVGLA IEAQAELAKENIDVSVVSMPSMDRFEKQSDEYKNEVLPADVKKRLAIEMGSSFGWGKY TGLEGDVLGIDRFGASAPGETIINEYGFSVPNVVNRVKALINK*" /label="tktA CDS" gene 1714615..1716618 /gene="tktA" /locus_tag="BSU_17890" /old_locus_tag="BSU17890" /label="tktA gene" misc_feature complement(1714819..1714838) /Source="Nicolas_upshift_promotors" /id="U1440" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.713286713286713" /psig="0.78921078921079" /xcortree=31 /SigmaFactorBS="ccactggcggaatcccttaagatcttcaatactaagatcaaa cccgcttaaatgaagcATGCTGTATAATAGTGCTGAcccgtgtccagcagataaaaca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1714836) /Source="Nicolas_upshifts" /id="U1440" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.713286713286713" /psig="0.78921078921079" /xcortree=31 /SigmaFactorBS="ccactggcggaatcccttaagatcttcaatactaagatcaaa cccgcttaaatgaagcATGCTGTATAATAGTGCTGAcccgtgtccagcagataaaaca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1716608 /Source="Nicolas_upshifts" /id="D975" /incds=0 /nref=230 /ntot=257 /MaxReadThrough="4.5478" /MaxDrop="6.66676" /score="16.4587041" /energy="-10.6" /TU="U1439" /idTUdmin="U1436" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1716620..1717278) /Source="Nicolas_S_feature" /locus_tag="new_1921866_1922524_c" /HighExp="Lbstat, C30, Salt, BC, S7, LPhT, S8, M0t90, T-0.40H, Glucon" /AntisenseName="yneE" /AntisenseCor="4.3891878649396997E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.604, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S661" upshifts 1716718 /Source="Nicolas_upshifts" /id="U1441" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.783216783216783" /psig="0.996003996003996" /xcortree=441 /SigmaFactorBS="tgtttatccgacaaaaatagtattggctgtttaacagtaata gacaattctttcttttcttCTTTTGTATAATAGAGAGCAaatgaaatgctgctggaaa a" /listShort="yneE, yneF, S662, S663, ccdA, yneI" /listLong="yneJ" /label="upshifts" misc_feature 1716719..1716738 /Source="Nicolas_upshift_promotors" /id="U1441" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.783216783216783" /psig="0.996003996003996" /xcortree=441 /SigmaFactorBS="tgtttatccgacaaaaatagtattggctgtttaacagtaata gacaattctttcttttcttCTTTTGTATAATAGAGAGCAaatgaaatgctgctggaaa a" /listShort="yneE, yneF, S662, S663, ccdA, yneI" /listLong="yneJ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1716771..1717217 /gene="pcfA" /locus_tag="BSU_17900" /old_locus_tag="BSU17900" /experiment="publication(s) with functional evidences, PMID:19682252, 25041308, 22720735, 27489185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19682252, 25041308, 22720735, 27489185; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor controlling DNA replication" /protein_id="NP_389673.1" /db_xref="EnsemblGenomes-Gn:BSU17900" /db_xref="EnsemblGenomes-Tr:CAB13674" /db_xref="GOA:P45707" /db_xref="InterPro:IPR019683" /db_xref="PDB:4TPS" /db_xref="SubtiList:BG11248" /db_xref="UniProtKB/Swiss-Prot:P45707" /translation="MERHYYTYLIKEEFANHYFGRESVMFELFQDYHWTSLEKQQYEM TEKQIQYITQPIPILHMHQRLKMNLNKTDYRQLDYIYRIALPKAKGHATFMMKEHMIE IVASGDYEAETIFFEVLRKVSPCFLAMDFNSKRYGWLNPVKERNFV*" /label="pcfA CDS" gene 1716771..1717217 /gene="pcfA" /locus_tag="BSU_17900" /old_locus_tag="BSU17900" /label="pcfA gene" misc_feature 1717241..1717260 /Source="Nicolas_upshift_promotors" /id="U1442" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2574 /SigmaFactorBS="atccggtgaaagaaagaaattttgtctaaaaccgaagaaaaa gagatgtaaaTGTTGTATAATAGCTTTTGGtttagtacactttaaactagacaacatg a" /listShort="yneF, S662, S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1717249 /Source="Nicolas_upshifts" /id="U1442" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2574 /SigmaFactorBS="atccggtgaaagaaagaaattttgtctaaaaccgaagaaaaa gagatgtaaaTGTTGTATAATAGCTTTTGGtttagtacactttaaactagacaacatg a" /listShort="yneF, S662, S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1717260..1717277) /Source="Nicolas_upshift_promotors" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1717278) /Source="Nicolas_upshifts" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1717296..1717300) /Source="Nicolas_upshift_promotors" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1717303..1717521 /gene="yneF" /locus_tag="BSU_17910" /old_locus_tag="BSU17910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_389674.1" /db_xref="EnsemblGenomes-Gn:BSU17910" /db_xref="EnsemblGenomes-Tr:CAB13675" /db_xref="GOA:P45708" /db_xref="InterPro:IPR005359" /db_xref="SubtiList:BG11249" /db_xref="UniProtKB/Swiss-Prot:P45708" /translation="MTLWVGILVGVVALLIGVALGFFIARKYMMSYLKKNPPINEQML RMMMMQMGMKPSQKKINQMMKAMNNQTK*" /label="yneF CDS" gene 1717303..1717521 /gene="yneF" /locus_tag="BSU_17910" /old_locus_tag="BSU17910" /label="yneF gene" downshifts 1717533 /Source="Nicolas_upshifts" /id="D976" /incds=0 /nref=243 /ntot=260 /MaxReadThrough="3.51446" /MaxDrop="7.54782" /score="0.133420982" /energy="-4.3" /TU="U1441,U1442" /idTUdmin="U1439" /TUdmin=287 /isTUend="FALSE" /label="downshifts" S_feature 1717578..1717877 /Source="Nicolas_S_feature" /locus_tag="new_1922824_1923123" /HighExp="S4, S3, S5, G180, S8, T5.0H, LoTm, G135, S6, S7" /AntisenseName="ynzD" /AntisenseCor="-0.33023056016157298" /AntisenseRegPval="-7.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S662" CDS complement(1717595..1717768) /gene="spo0D" /locus_tag="BSU_17920" /old_locus_tag="BSU17920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11679073, 15187183, 17350627, 22303282, 23378509, 27965289" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11679073, 15187183, 17350627, 22303282, 23378509, 27965289; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="Spo0A-P phosphatase" /protein_id="NP_389675.1" /db_xref="EnsemblGenomes-Gn:BSU17920" /db_xref="EnsemblGenomes-Tr:CAB13676" /db_xref="GOA:O31819" /db_xref="InterPro:IPR018540" /db_xref="InterPro:IPR037208" /db_xref="SubtiList:BG13467" /db_xref="UniProtKB/Swiss-Prot:O31819" /translation="MIREHLLKEIEKKRAELLQIVMANGMTSHITIELSQELDHLLIQ YQKQRLRAVAGDE*" /label="spo0D CDS" gene complement(1717595..1717768) /gene="spo0D" /locus_tag="BSU_17920" /old_locus_tag="BSU17920" /label="spo0D gene" downshifts complement(1717608) /Source="Nicolas_upshifts" /id="D977" /incds=0 /nref=109 /ntot=219 /MaxReadThrough="4.0851" /MaxDrop="5.22565" /score="1.92055758" /energy="-4.3" /TU="U1444,U1446" /idTUdmin="U1444" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1717806..1717825) /Source="Nicolas_upshift_promotors" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1717813) /Source="Nicolas_upshifts" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1717839..1717846) /Source="Nicolas_upshift_promotors" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1717848..1717856 /Source="Nicolas_upshift_promotors" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1717868..1717887) /Source="Nicolas_upshift_promotors" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1717868..1717886 /Source="Nicolas_upshift_promotors" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1717879..1717987 /Source="Nicolas_S_feature" /locus_tag="new_1923125_1923233" /HighExp="T4.0H, T3.30H, T3.0H, S2, Lbstat, T5.0H, T2.30H, S4, T-1.40H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA, SigA" /TUshortPSig="0.999, 1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S663" upshifts 1717879 /Source="Nicolas_upshifts" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1717880) /Source="Nicolas_upshifts" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1717902..1717909) /Source="Nicolas_upshift_promotors" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1717988..1718695 /gene="ccdA" /locus_tag="BSU_17930" /old_locus_tag="BSU17930" /function="16.10: Respire" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16771673, 16850406, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16771673, 16850406, 19682263; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome c-type biogenesis protein CcdA; thiol-disulfide oxido-reductase" /protein_id="NP_389676.1" /db_xref="EnsemblGenomes-Gn:BSU17930" /db_xref="EnsemblGenomes-Tr:CAB13677" /db_xref="GOA:P45706" /db_xref="InterPro:IPR003834" /db_xref="SubtiList:BG11240" /db_xref="UniProtKB/Swiss-Prot:P45706" /translation="MGDVNYFLTFGAGFLSFISPCCLPLYPAFLSYITGVSMDDVKTE KLLLQKRSLFHTLCFLLGFSVIFIALGYGTSFIGSLFRDYHDAIRQIGALLIILFGFI TLGVFRPEAMMKERRIHFKHKPSGFLGSVLIGMAFAAGWTPCTGPILAAVITLAGTNP GSAVPYMMLYVLGFAVPFLLLSFFITKLKWIRKNQLFIMKAGGVLMIVIGVLLFFNWM SLIIILLSDLFGGFTGF*" /label="ccdA CDS" gene 1717988..1718695 /gene="ccdA" /locus_tag="BSU_17930" /old_locus_tag="BSU17930" /label="ccdA gene" promotor_-35 1718715..1718722 /Source="Nicolas_upshift_promotors" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1718734..1718753 /Source="Nicolas_upshift_promotors" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1718742 /Source="Nicolas_upshifts" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1718784..1719146 /gene="yneI" /locus_tag="BSU_17940" /old_locus_tag="BSU17940" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10781554; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative response regulator (CheY homolog)" /protein_id="NP_389677.1" /db_xref="EnsemblGenomes-Gn:BSU17940" /db_xref="EnsemblGenomes-Tr:CAB13678" /db_xref="GOA:P45709" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11250" /db_xref="UniProtKB/Swiss-Prot:P45709" /translation="MTRVLVVDDAKFMRVKIREILEEANYIIAGEAADGEQAADLYKK LRPDLVTMDITMPVKNGIKALRDILTFDPKAKVIMCTAMRQQRIVTEAIELGAKDFIV KPFEETKVLEAVSRVMGH*" /label="yneI CDS" gene 1718784..1719146 /gene="yneI" /locus_tag="BSU_17940" /old_locus_tag="BSU17940" /label="yneI gene" promotor_-35 1719164..1719167 /Source="Nicolas_upshift_promotors" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1719182..1719201 /Source="Nicolas_upshift_promotors" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1719193 /Source="Nicolas_upshifts" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1719225..1719716 /gene="yneJ" /locus_tag="BSU_17950" /old_locus_tag="BSU17950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10781554, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389678.1" /db_xref="EnsemblGenomes-Gn:BSU17950" /db_xref="EnsemblGenomes-Tr:CAB13679" /db_xref="GOA:P45710" /db_xref="InterPro:IPR009916" /db_xref="InterPro:IPR031306" /db_xref="SubtiList:BG11251" /db_xref="UniProtKB/Swiss-Prot:P45710" /translation="MISMMIIVSSIIAVLMAVAVMVVRIKSSDKPVSPKKIILPPIFM STGALMFLFPVFWVTGAEFLEAFTLGVIFSIFLIKTSKFEIKNNEIYMKRSKAFVFIL VGLLVIRIVMKSILSTSIDYGALSGMFWILAFGMIVPWRIAMYLSYRKLHNELQSSNI QMN*" /label="yneJ CDS" gene 1719225..1719716 /gene="yneJ" /locus_tag="BSU_17950" /old_locus_tag="BSU17950" /label="yneJ gene" downshifts 1719712 /Source="Nicolas_upshifts" /id="D978" /incds=0 /nref=110 /ntot=273 /MaxReadThrough="1.09905" /MaxDrop="5.9692" /score="16.4219082" /energy="-9.7" /TU="NA" /idTUdmin="U1445" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(1719747..1720175) /gene="yneK" /locus_tag="BSU_17960" /old_locus_tag="BSU17960" /experiment="publication(s) with functional evidences, PMID:23060960" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23060960; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor interacting with DynA" /protein_id="NP_389679.1" /db_xref="EnsemblGenomes-Gn:BSU17960" /db_xref="EnsemblGenomes-Tr:CAB13680" /db_xref="InterPro:IPR020203" /db_xref="SubtiList:BG11252" /db_xref="UniProtKB/Swiss-Prot:P45711" /translation="MLEGWFLWFILFWVIMMVVLLSIGGFFMFRKFLKRLPKEDGRSE LDWQDYYIENSRHLWNDENKQFLDELTAPVPELFRDAAKAKIAGKIGELALKEKVAKI DQQLMIKGYILATPKRDHTFLKRHLRDKKIDLEPYQTLLK*" /label="yneK CDS" gene complement(1719747..1720175) /gene="yneK" /locus_tag="BSU_17960" /old_locus_tag="BSU17960" /label="yneK gene" downshifts complement(1719764) /Source="Nicolas_upshifts" /id="D979" /incds=0 /nref=188 /ntot=245 /MaxReadThrough="1.60911" /MaxDrop="5.09033" /score="10.710816" /energy="-9.7" /TU="NA" /idTUdmin="U1449" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1720193..1720212) /Source="Nicolas_upshift_promotors" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1720205) /Source="Nicolas_upshifts" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1720207..1720292) /Source="Nicolas_S_feature" /locus_tag="new_1925453_1925538_c" /HighExp="S8, S6, S7, LBGstat, C30, dia15, S0, Cold, T1.0H, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.958, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S664" promotor_-35 complement(1720226..1720233) /Source="Nicolas_upshift_promotors" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1720263..1720272 /Source="Nicolas_upshift_promotors" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1720282..1720391 /Source="Nicolas_S_feature" /locus_tag="new_1925528_1925637" /HighExp="S8, BT, B36, S7, G/S, Pyr, B60, S6, Glucon, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S665" upshifts 1720282 /Source="Nicolas_upshifts" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1720285..1720304 /Source="Nicolas_upshift_promotors" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1720287..1720306) /Source="Nicolas_upshift_promotors" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1720292) /Source="Nicolas_upshifts" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1720294..1720377) /Source="Nicolas_S_feature" /locus_tag="new_1925540_1925623_c" /HighExp="S8, S6, S7, C30, BT, S5, Pyr, Glucon, BC, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S666" promotor_-35 complement(1720321..1720324) /Source="Nicolas_upshift_promotors" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1720348 /Source="Nicolas_upshifts" /id="D980" /incds=0 /nref=9 /ntot=30 /MaxReadThrough="3.76639" /MaxDrop="5.34013" /score="5.70696998" /energy="-12.7" /TU="U1450" /idTUdmin="U1450" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(1720409..1720801) /gene="cotM" /locus_tag="BSU_17970" /old_locus_tag="BSU17970" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9068633, 11150673" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9068633, 11150673; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_389680.1" /db_xref="EnsemblGenomes-Gn:BSU17970" /db_xref="EnsemblGenomes-Tr:CAB13681" /db_xref="GOA:Q45058" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG11822" /db_xref="UniProtKB/Swiss-Prot:Q45058" /translation="MWRNASMNHSKRNDANDFDSMDEWLRQFFEDPFAWYDETLPIDL YETSQQYIIEADLTFLQPTQVTVTLSGCEFILTVKSSGQTFEKQMMLPFYFNDKNIQV ECENQILTVAVNKETEDGSSFSLQFPLS*" /label="cotM CDS" gene complement(1720409..1720801) /gene="cotM" /locus_tag="BSU_17970" /old_locus_tag="BSU17970" /label="cotM gene" downshifts complement(1720422) /Source="Nicolas_upshifts" /id="D981" /incds=0 /nref=20 /ntot=92 /MaxReadThrough="4.44864" /MaxDrop="4.9615" /score="11.5991121" /energy="-12.7" /TU="U1454" /idTUdmin="U1456" /TUdmin=486 /isTUend="FALSE" /label="downshifts" promotor_-35 1720644..1720649 /Source="Nicolas_upshift_promotors" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="promotor_-35" promotor_-10 1720665..1720683 /Source="Nicolas_upshift_promotors" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="promotor_-10" upshifts 1720669 /Source="Nicolas_upshifts" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="upshifts" promotor_-35 1720779..1720783 /Source="Nicolas_upshift_promotors" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1720793..1720807 /Source="Nicolas_upshift_promotors" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1720808..1720827) /Source="Nicolas_upshift_promotors" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1720810 /Source="Nicolas_upshifts" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1720823) /Source="Nicolas_upshifts" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1720841..1720850) /Source="Nicolas_upshift_promotors" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1720882..1721028) /gene="sspP" /locus_tag="BSU_17980" /old_locus_tag="BSU17980" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_389681.1" /db_xref="EnsemblGenomes-Gn:BSU17980" /db_xref="EnsemblGenomes-Tr:CAB13682" /db_xref="GOA:P71032" /db_xref="InterPro:IPR012614" /db_xref="SubtiList:BG11921" /db_xref="UniProtKB/Swiss-Prot:P71032" /translation="MTNKNTSKDMHKNAPKGHNPGQPEPLSGSKKVKNRNHTRQKHNS SHDM*" /label="sspP CDS" gene complement(1720882..1721028) /gene="sspP" /locus_tag="BSU_17980" /old_locus_tag="BSU17980" /label="sspP gene" downshifts complement(1720903) /Source="Nicolas_upshifts" /id="D982" /incds=0 /nref=42 /ntot=61 /MaxReadThrough="1.80349" /MaxDrop="6.88836" /score="0.778507843" /energy="-4.3" /TU="NA" /idTUdmin="U1456" /TUdmin=5 /isTUend="TRUE" /label="downshifts" CDS complement(1721060..1721206) /gene="sspO" /locus_tag="BSU_17990" /old_locus_tag="BSU17990" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9852018, 10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018, 10806362; Product type s: structure" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_389682.1" /db_xref="EnsemblGenomes-Gn:BSU17990" /db_xref="EnsemblGenomes-Tr:CAB13683" /db_xref="GOA:P71031" /db_xref="InterPro:IPR012613" /db_xref="SubtiList:BG11920" /db_xref="UniProtKB/Swiss-Prot:P71031" /translation="MVKRKANHVINGMNDAKSQGKGAGYIENDQLVLTEAERQNNKKR KTNQ*" /label="sspO CDS" gene complement(1721060..1721206) /gene="sspO" /locus_tag="BSU_17990" /old_locus_tag="BSU17990" /label="sspO gene" S_feature 1721206..1721339 /Source="Nicolas_S_feature" /locus_tag="new_1926452_1926585" /HighExp="S8, S7, S3, S6, LoTm, S4, S5, BT, Pyr, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S667" upshifts 1721206 /Source="Nicolas_upshifts" /id="U1455" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.228771228771229" /psig="0.312687312687313" /xcortree=1215 /SigmaFactorBS="tgccttggctttttgcgtcattcattccgttaatgacgtgat tcgcttttcttttgaccatcattatcaccTCAatcataatatggcttcttttattgtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1721217..1721219 /Source="Nicolas_upshift_promotors" /id="U1455" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.228771228771229" /psig="0.312687312687313" /xcortree=1215 /SigmaFactorBS="tgccttggctttttgcgtcattcattccgttaatgacgtgat tcgcttttcttttgaccatcattatcaccTCAatcataatatggcttcttttattgtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(1721222..1721233) /Source="Nicolas_upshift_promotors" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1721236) /Source="Nicolas_upshifts" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1721248..1721254) /Source="Nicolas_upshift_promotors" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1721329..1721336 /Source="Nicolas_upshift_promotors" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1721341..1721433 /Source="Nicolas_S_feature" /locus_tag="new_1926587_1926679" /HighExp="B60, M40t90, T0.0H, HiOs, T4.0H, T5.0H, T2.30H, M0t90, Sw, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S668" upshifts 1721341 /Source="Nicolas_upshifts" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1721351..1721370 /Source="Nicolas_upshift_promotors" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(1721392) /Source="Nicolas_upshifts" /id="D983" /incds=0 /nref=1 /ntot=67 /MaxReadThrough="2.77282" /MaxDrop="4.02811" /score="0.778507843" /energy="-4.3" /TU="NA" /idTUdmin="U1458" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1721434..1724163 /gene="citB" /locus_tag="BSU_18000" /old_locus_tag="BSU18000" /EC_number="4.2.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9642180, 10468622, 10656796, 14636591, 16395550, 16923907, 22720735, 23354745" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9642180, 10468622, 10656796, 14636591, 16395550, 16923907, 22720735, 23354745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aconitate hydratase (bifunctional aconitase)" /protein_id="NP_389683.1" /db_xref="EnsemblGenomes-Gn:BSU18000" /db_xref="EnsemblGenomes-Tr:CAB13684" /db_xref="GOA:P09339" /db_xref="InterPro:IPR000573" /db_xref="InterPro:IPR001030" /db_xref="InterPro:IPR006249" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR015931" /db_xref="InterPro:IPR015932" /db_xref="InterPro:IPR018136" /db_xref="InterPro:IPR036008" /db_xref="SubtiList:BG10478" /db_xref="UniProtKB/Swiss-Prot:P09339" /translation="MANEQKTAAKDVFQARKTFTTNGKTYHYYSLKALEDSGIGKVSK LPYSIKVLLESVLRQVDGFVIKKEHVENLAKWGTAELKDIDVPFKPSRVILQDFTGVP AVVDLASLRKAMAAVGGDPDKINPEIPVDLVIDHSVQVDKAGTEDALAVNMDLEFERN AERYKFLSWAKKAFNNYQAVPPATGIVHQVNLEFLASVVHAIEEDGELVTYPDTLVGT DSHTTMINGIGVLGWGVGGIEAEAGMLGQPSYFPVPEVIGAKLVGKLPNGTTATDLAL KVTQVLREKGVVGKFVEFFGPGIAELPLADRATIANMAPEYGATCGFFPVDEEALNYL RLTGRDPEHIDVVEAYCRSNGLFYTPDAEDPQFTDVVEIDLSQIEANLSGPKRPQDLI PLSAMQETFKKQLVSPAGNQGFGLNAEEENKEIKFKLLNGEETVMKTGAIAIAAITSC TNTSNPYVLIGAGLVAKKAVELGLKVPNYVKTSLAPGSKVVTGYLVNSGLLPYMKELG FNLVGYGCTTCIGNSGPLSPEIEEAVAKNDLLITSVLSGNRNFEGRIHPLVKGNYLAS PPLVVAYALAGTVNINLKTDPIGVGKDGQNVYFNDIWPSMDEINALVKQTVTPELFRK EYETVFDDNKRWNEIETTDEALYKWDNDSTYIQNPPFFEEMSVEPGKVEPLKGLRVVG KFGDSVTTDHISPAGAIGKDTPAGKYLQEKGVSPRDFNSYGSRRGNHEVMMRGTFANI RIKNQIAPGTEGGFTTYWPTGEVTSIYDACMKYKEDKTGLVVLAGKDYGMGSSRDWAA KGTNLLGIRTVIAESFERIHRSNLVFMGVLPLQFKQGENADTLGLTGKEVIEVDVDET VRPRDLVTVRAINEDGNVTTFEAVVRFDSEVEIDYYRHGGILQMVLREKMKQS*" /label="citB CDS" gene 1721434..1724163 /gene="citB" /locus_tag="BSU_18000" /old_locus_tag="BSU18000" /label="citB gene" misc_feature complement(1721454..1721458) /Source="Nicolas_upshift_promotors" /id="U1458" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.001998001998002" /xcortree=88 /SigmaFactorBS="agtaatgatatgttttcccatttgtagtaaacgtttttctcg cttggaaaacgtcttttgCTGCAgttttttgctcgtttgccattctccaaaatccccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1721458) /Source="Nicolas_upshifts" /id="U1458" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.001998001998002" /xcortree=88 /SigmaFactorBS="agtaatgatatgttttcccatttgtagtaaacgtttttctcg cttggaaaacgtcttttgCTGCAgttttttgctcgtttgccattctccaaaatccccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1724164..1724234 /Source="Nicolas_S_feature" /locus_tag="new_1929410_1929480" /HighExp="M9-stat, B60, M40t90, Glucon, M0t90, MG-0.2, Mal, T2.30H, MG-0.1, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S669" CDS 1724235..1724747 /gene="yneN" /locus_tag="BSU_18010" /old_locus_tag="BSU18010" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15342593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane-bound proteins with a thioredoxin-like domain" /protein_id="NP_389684.1" /db_xref="EnsemblGenomes-Gn:BSU18010" /db_xref="EnsemblGenomes-Tr:CAB13685" /db_xref="GOA:O31820" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13451" /db_xref="UniProtKB/Swiss-Prot:O31820" /translation="MLKKWLAGILLIMLVGYTGWNLYQTYSKKEVGIQEGQQAPDFSL KTLSGEKSSLQDAKGKKVLLNFWATWCKPCRQEMPAMEKLQKEYADKLAVVAVNFTSA EKSEKQVRAFADTYDLTFPILIDKKGINADYNVMSYPTTYILDEKGVIQDIHVGTMTK KEMEQKLDLD*" /label="yneN CDS" gene 1724235..1724747 /gene="yneN" /locus_tag="BSU_18010" /old_locus_tag="BSU18010" /label="yneN gene" downshifts 1724704 /Source="Nicolas_upshifts" /id="D984" /incds=0 /nref=115 /ntot=218 /MaxReadThrough="3.76369" /MaxDrop="5.09954" /score="13.5401842" /energy="-6.9" /TU="U1457" /idTUdmin="U1457" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" promotor_-35 1724773..1724779 /Source="Nicolas_upshift_promotors" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1724792 /Source="Nicolas_upshifts" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1724794..1724805 /Source="Nicolas_upshift_promotors" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1724828..1724953 /gene="ynzL" /locus_tag="BSU_18019" /old_locus_tag="BSU18019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097732.1" /db_xref="EnsemblGenomes-Gn:BSU18019" /db_xref="EnsemblGenomes-Tr:CAX52626" /db_xref="InterPro:IPR025004" /db_xref="UniProtKB/Swiss-Prot:C0H418" /translation="MKKMRKRSFHELVMENKKELMTNTEYLNQLEEKLEQRFKQK*" /label="ynzL CDS" gene 1724828..1724953 /gene="ynzL" /locus_tag="BSU_18019" /old_locus_tag="BSU18019" /label="ynzL gene" downshifts complement(1724846) /Source="Nicolas_upshifts" /id="D985" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="3.12259" /MaxDrop="3.48183" /score="-0.0160782027" /energy="-13.9" /TU="NA" /idTUdmin="U1462" /TUdmin=1298 /isTUend="FALSE" /label="downshifts" promotor_-35 1724967..1724973 /Source="Nicolas_upshift_promotors" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1724988..1724999 /Source="Nicolas_upshift_promotors" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1724990 /Source="Nicolas_upshifts" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="upshifts" CDS 1725018..1725164 /gene="sspN" /locus_tag="BSU_18020" /old_locus_tag="BSU18020" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054579.2" /db_xref="EnsemblGenomes-Gn:BSU18020" /db_xref="EnsemblGenomes-Tr:CAE01455" /db_xref="GOA:Q7WY69" /db_xref="InterPro:IPR012612" /db_xref="SubtiList:BG14179" /db_xref="UniProtKB/Swiss-Prot:Q7WY69" /translation="MGNNKKNGQPQYAPSHLGTKPVKYKANKGEKMHDTSGQRPIIMQ TKGE*" /label="sspN CDS" gene 1725018..1725164 /gene="sspN" /locus_tag="BSU_18020" /old_locus_tag="BSU18020" /label="sspN gene" CDS 1725201..1725452 /gene="sspT" /locus_tag="BSU_18030" /old_locus_tag="BSU18030" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (thioredoxin-like protein)" /protein_id="NP_389685.1" /db_xref="EnsemblGenomes-Gn:BSU18030" /db_xref="EnsemblGenomes-Tr:CAB13686" /db_xref="GOA:Q45060" /db_xref="InterPro:IPR017524" /db_xref="SubtiList:BG11806" /db_xref="UniProtKB/Swiss-Prot:Q45060" /translation="MTKNQNQYQQPNPDDRSDNVEKLQDMVQNTIENIEEAEASMEFA SGEDKQRIKEKNARREQSIEAFRNEIQDESAARQNGYRS*" /label="sspT CDS" gene 1725201..1725452 /gene="sspT" /locus_tag="BSU_18030" /old_locus_tag="BSU18030" /label="sspT gene" downshifts 1725430 /Source="Nicolas_upshifts" /id="D986" /incds=0 /nref=41 /ntot=49 /MaxReadThrough="2.07653" /MaxDrop="7.06685" /score="32.1193211" /energy="-7" /TU="NA" /idTUdmin="U1457" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1725473..1725478 /Source="Nicolas_upshift_promotors" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1725492..1725511 /Source="Nicolas_upshift_promotors" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1725496..1725587 /Source="Nicolas_S_feature" /locus_tag="new_1930742_1930833" /HighExp="Etha, dia5, dia15, Diami, H2O2, G180, Salt, G150, BMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S670" upshifts 1725496 /Source="Nicolas_upshifts" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1725588..1725953 /gene="yneP" /locus_tag="BSU_18040" /old_locus_tag="BSU18040" /EC_number="3.1.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11959124, 11994151, 16294310, 18338382; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA thioesterase" /protein_id="YP_054580.1" /db_xref="EnsemblGenomes-Gn:BSU18040" /db_xref="EnsemblGenomes-Tr:CAB13687" /db_xref="GOA:Q45061" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR006684" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG11823" /db_xref="UniProtKB/Swiss-Prot:Q45061" /translation="MGIVYHANYLVWMEVGRTALIKDLGFLYSDMEKKGVLSPVVDIN ISYKKPLHYGETAVVHTWIEDYNGFKTVYGYHIYNPAGELSIKATSSHICVDKESFKP IQFRKAFPDWHTAYEKAKK*" /label="yneP CDS" gene 1725588..1725953 /gene="yneP" /locus_tag="BSU_18040" /old_locus_tag="BSU18040" /label="yneP gene" CDS 1725969..1726268 /gene="yneQ" /locus_tag="BSU_18050" /old_locus_tag="BSU18050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389687.1" /db_xref="EnsemblGenomes-Gn:BSU18050" /db_xref="EnsemblGenomes-Tr:CAB13688" /db_xref="SubtiList:BG11824" /db_xref="UniProtKB/Swiss-Prot:Q45062" /translation="MAFGVKREELNRWKQAVKRGEIAFLTHYWLDDRFPEAKTVTKAG CADIDKLVQWGAAYGLKKEWIHKKSEFPHFDLLGETQKYILEQENLTDHLIRFHL*" /label="yneQ CDS" gene 1725969..1726268 /gene="yneQ" /locus_tag="BSU_18050" /old_locus_tag="BSU18050" /label="yneQ gene" downshifts 1726244 /Source="Nicolas_upshifts" /id="D987" /incds=0 /nref=55 /ntot=217 /MaxReadThrough="3.04989" /MaxDrop="5.5978" /score="-4.41102273" /energy="-6" /TU="NA" /idTUdmin="U1461" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1726299..1726586) /gene="yneR" /locus_tag="BSU_18060" /old_locus_tag="BSU18060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 23176286" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389688.1" /db_xref="EnsemblGenomes-Gn:BSU18060" /db_xref="EnsemblGenomes-Tr:CAB13689" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR008326" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG11825" /db_xref="UniProtKB/Swiss-Prot:Q45063" /translation="MNMTINEDALNWYKEELDLESGDQVRFFVRYGGCSNVQKGFSLG VAKDAPQEAGVTAEADGITFFIEESDLWYFDNHDLLVSYSEDADEPVFEYQ*" /label="yneR CDS" gene complement(1726299..1726586) /gene="yneR" /locus_tag="BSU_18060" /old_locus_tag="BSU18060" /label="yneR gene" downshifts complement(1726320) /Source="Nicolas_upshifts" /id="D988" /incds=0 /nref=216 /ntot=260 /MaxReadThrough="3.77766" /MaxDrop="7.20006" /score="-5.4451498" /energy="-6" /TU="U1462,U1463" /idTUdmin="U1463" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" downshifts complement(1726386) /Source="Nicolas_upshifts" /id="D989" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="7.5674" /MaxDrop="3.11178" /score="-5.4451498" /energy="-6" /TU="U1462,U1463" /idTUdmin="U1463" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1726616..1726635) /Source="Nicolas_upshift_promotors" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1726628) /Source="Nicolas_upshifts" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1726651..1726658) /Source="Nicolas_upshift_promotors" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1726674..1727255) /gene="plsY" /locus_tag="BSU_18070" /old_locus_tag="BSU18070" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15849754, 16850406, 16949372, 17005971, 17308305, 17557823, 17645809, 19282621, 26644587" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15849754, 16850406, 16949372, 17005971, 17308305, 17557823, 17645809, 19282621, 26644587; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acylphosphate:glycerol-3-phosphate O-acyltransferase" /protein_id="NP_389689.1" /db_xref="EnsemblGenomes-Gn:BSU18070" /db_xref="EnsemblGenomes-Tr:CAB13690" /db_xref="GOA:Q45064" /db_xref="InterPro:IPR003811" /db_xref="SubtiList:BG11826" /db_xref="UniProtKB/Swiss-Prot:Q45064" /translation="MLIALLIILAYLIGSIPSGLIVGKLAKGIDIREHGSGNLGATNA FRTLGVKAGSVVIAGDILKGTLATALPFLMHVDIHPLLAGVFAVLGHVFPIFAKFKGG KAVATSGGVLLFYAPLLFITMVAVFFIFLYLTKFVSLSSMLTGIYTVIYSFFVHDTYL LIVVTLLTIFVIYRHRANIKRIINKTEPKVKWL*" /label="plsY CDS" gene complement(1726674..1727255) /gene="plsY" /locus_tag="BSU_18070" /old_locus_tag="BSU18070" /label="plsY gene" S_feature 1727256..1727386 /Source="Nicolas_S_feature" /locus_tag="new_1932502_1932632" /HighExp="C30, S8, S7, S5, S6, S4, BC, S3, T4.0H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S671" misc_feature complement(1727281..1727300) /Source="Nicolas_upshift_promotors" /id="U1463" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2140 /SigmaFactorBS="tttgatttgatttgtaagcaaactttacaaaaaaacttatca tcagatcatgacatctCATGTTAAAATAAAAAGAAGggaatttgaaaaaggagaaatg t" /listShort="plsY, yneR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1727298) /Source="Nicolas_upshifts" /id="U1463" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2140 /SigmaFactorBS="tttgatttgatttgtaagcaaactttacaaaaaaacttatca tcagatcatgacatctCATGTTAAAATAAAAAGAAGggaatttgaaaaaggagaaatg t" /listShort="plsY, yneR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1727371..1727374 /Source="Nicolas_upshift_promotors" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1727388 /Source="Nicolas_upshifts" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1727390..1727409 /Source="Nicolas_upshift_promotors" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1727425..1727832 /gene="yneT" /locus_tag="BSU_18080" /old_locus_tag="BSU18080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA-binding protein" /protein_id="NP_389690.1" /db_xref="EnsemblGenomes-Gn:BSU18080" /db_xref="EnsemblGenomes-Tr:CAB13691" /db_xref="GOA:Q45065" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11827" /db_xref="UniProtKB/Swiss-Prot:Q45065" /translation="MQNPSKAEIKEILQRSKRIAVVGLSDRPDRTSHMVSKAMQDAGY EIIPVNPTIDEALGVKAVSSLKEIDGPIDIVNVFRRSEQLPGVAEEFLETDAPVFWAQ QGLVNEEAYQMLKEKGRTVIMDLCIKVAHAVTK*" /label="yneT CDS" gene 1727425..1727832 /gene="yneT" /locus_tag="BSU_18080" /old_locus_tag="BSU18080" /label="yneT gene" downshifts 1727828 /Source="Nicolas_upshifts" /id="D990" /incds=0 /nref=63 /ntot=221 /MaxReadThrough="4.35976" /MaxDrop="5.49229" /score="-2.11194139" /energy="-6" /TU="U1464" /idTUdmin="U1461" /TUdmin=1584 /isTUend="FALSE" /label="downshifts" promotor_-35 1727894..1727897 /Source="Nicolas_upshift_promotors" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1727912..1727931 /Source="Nicolas_upshift_promotors" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1727916..1728230 /Source="Nicolas_S_feature" /locus_tag="new_1933162_1933476" /HighExp="H2O2, G150, G180, Etha, Oxctl, LBGexp, dia0, Lbexp, M40t45, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S672" upshifts 1727916 /Source="Nicolas_upshifts" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="upshifts" CDS 1728231..1730198 /gene="parE" /locus_tag="BSU_18090" /old_locus_tag="BSU18090" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8969507, 9539793, 12682299, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8969507, 9539793, 12682299, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="subunit B of DNA topoisomerase IV (ATP-dependent)" /protein_id="NP_389691.2" /db_xref="EnsemblGenomes-Gn:BSU18090" /db_xref="EnsemblGenomes-Tr:CAB13692" /db_xref="GOA:Q59192" /db_xref="InterPro:IPR001241" /db_xref="InterPro:IPR002288" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005740" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013506" /db_xref="InterPro:IPR013759" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018522" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11804" /db_xref="UniProtKB/Swiss-Prot:Q59192" /translation="MARKQQFDYNEDAIQVLEGLEAVRKRPGMYIGSTDARGLHHLVY EIVDNSVDEVLAGHGDHIIVKIHKDNSISVQDRGRGMPTGMHKLGKPTPEVILTVLHA GGKFGQGGYKTSGGLHGVGASVVNALSEWLTVTIERDGFVYQQRFENGGKPVTSLEKI GKTKKTGTLTHFKPDPTMFSTTTYNFETLSERLRESAFLLKGLKIELIDERNDQREVF YYENGIEAFVAYLNEEKDVLSEVVSFEGEHHSIEVDFAFQFNDGYSENILSFVNNVRT KDGGTHESGAKTAMTRAFNEYARKVALLKEKDKNLEGTDIREGLSAIISVRIPEELLQ FEGQTKGKLGTSEARSAVDAIVSEQLAYFLEENRDTATLLVKKAIKASQAREAARKAR EEARSGKKRKKSEATLSGKLTPAGSRNPAKNELYLVEGDSAGGSAKQGRDRRFQAVLP LRGKVINTEKAKLADIFKNEEINTIIHAIGGGVGADFSIDDINYDKIIIMTDADTDGA HIQVLLLTFFYRYMKPLIEHGKVFIALPPLYKVSKGSGKKEIIEYAWSDEEMGDVLKK VGKGYTIQRYKGLGEMNADQLWETTMNPESRTLVRVKIDDAARVERRVTTLMGDKVEP RRKWIEKNVAFGLDEESNILENENLSVAEEV*" /label="parE CDS" gene 1728231..1730198 /gene="parE" /locus_tag="BSU_18090" /old_locus_tag="BSU18090" /label="parE gene" CDS 1730202..1732622 /gene="parC" /locus_tag="BSU_18100" /old_locus_tag="BSU18100" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9539793, 12682299, 16267290, 16272394, 24440393" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9539793, 12682299, 16267290, 16272394, 24440393; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="subunit A of DNA topoisomerase IV (ATP-dependent)" /protein_id="NP_389692.2" /db_xref="EnsemblGenomes-Gn:BSU18100" /db_xref="EnsemblGenomes-Tr:CAB13693" /db_xref="GOA:Q45066" /db_xref="InterPro:IPR002205" /db_xref="InterPro:IPR005741" /db_xref="InterPro:IPR006691" /db_xref="InterPro:IPR013757" /db_xref="InterPro:IPR013758" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR035516" /db_xref="SubtiList:BG11803" /db_xref="UniProtKB/Swiss-Prot:Q45066" /translation="MSQPELFHDLPLEEVIGDRFGRYSKYIIQDRALPDARDGLKPVQ RRILYAMHTDGNTFDKNFRKAAKTVGNVIGNYHPHGDSSVYEAMVRMSQDWKVRNVLI EMHGNNGSIDGDPPAAMRYTEARLSPIASELLRDIDKNTVEFVPNFDDTSKEPVVLPA MFPNLLVNGSTGISAGYATDIPPHHLGEVIDAVIKRIQMPSCSVDELMEVIKGPDFPT GGIIQGVDGIRKAYETGKGKIIIRGKAEIETIRGGREQIVITEIPFEVNKANLVKKMD EFRIDKKVEGISEVRDETDRTGLRVVIELKKEADAKGILNFLYKNTDLQITYNFNMVA IHNRRPMLMSLPSILDAYIGHQKEVVTNRSVYELQKAKDRHHIVEGLMKALSILDEVI ATIRSSSDKRDAKNNLIAKYEFTEPQAEAIVSLQLYRLTNTDITALKEEAEELGKKIE ELESILSNDKKLLKVITNSLKALKKKYADTRRSVIEEKIEEIKINLEVMVASEDVYVT VTKDGYLKRTSQRSFAASNGQDFGMKDTDRMLHQFEMNTTDVLLLFTNKGSYIYCPVH QLPDIRWKDMGQHFSNLITIDRDETIVKAIPIKEFDPSAYLLFFTKNGMVKKTELTHY KAQRYSKALVALNLKGEDELIDVHVTNGESQIFMATHLGYGLWFGEDEVNVVGARAAG VKGINLKEDDFVVSGEILQQSDSIVLFTQRGAVKRMSLSEFEKTSRAKRGVVMLRELK KNPHRVVALFACGLEQRLMAETEKGDRKELQTKELRTNDRYSNGSFFFDEEESGKVTA VWRLHTEQ*" /label="parC CDS" gene 1730202..1732622 /gene="parC" /locus_tag="BSU_18100" /old_locus_tag="BSU18100" /label="parC gene" downshifts 1732602 /Source="Nicolas_upshifts" /id="D991" /incds=0 /nref=227 /ntot=255 /MaxReadThrough="0.556700000000001" /MaxDrop="5.87714" /score="9.15080033" /energy="-14.6" /TU="NA" /idTUdmin="U1465" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1732630..1732819) /Source="Nicolas_S_feature" /locus_tag="new_1937876_1938065_c" /HighExp="LPhT, B60, Etha, B36, Gly, LoTm, Sw, BC, S8, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99806099999999998" /TUshortSig="SigA, SigA, SigK" /TUshortPSig="0.968, 0.994, 0.642" /TUlongSig="NA" /TUlongPSig="NA" /label="S673" CDS complement(1732669..1732845) /gene="ynfCc" /locus_tag="BSU_18109" /old_locus_tag="BSU18109" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (C-terminus)" /db_xref="PSEUDO:SOX90559.1" /translation="MFNITRLCNENMRRLLNMLFILRMVILGLFSFTALNLFVWQGIE VIHAVTDLFTNHES*" /label="ynfCc CDS" gene complement(1732669..1732845) /gene="ynfCc" /locus_tag="BSU_18109" /old_locus_tag="BSU18109" /pseudo /label="ynfCc gene" downshifts complement(1732673) /Source="Nicolas_upshifts" /id="D992" /incds=0 /nref=153 /ntot=267 /MaxReadThrough="0.609599999999999" /MaxDrop="7.72532" /score="38.0779167" /energy="-14.6" /TU="NA" /idTUdmin="U1467" /TUdmin=5 /isTUend="TRUE" /label="downshifts" CDS complement(1732820..1733230) /gene="ynfCn" /locus_tag="BSU_18110" /old_locus_tag="BSU18110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /db_xref="EnsemblGenomes-Gn:BSU18110" /db_xref="EnsemblGenomes-Tr:CAB13694" /db_xref="GOA:Q45067" /db_xref="PSEUDO:CAB13694.1" /db_xref="SubtiList:BG11828" /db_xref="UniProtKB/Swiss-Prot:Q45067" /translation="MDWGIIIKIFSNIKGGGDHLKKVTILKASILFLAIASFHLFSIP HAFDIGHHYKAVADQQEMHEMKAGQNADDEKKSITGAFTLTALWAMAVLLLTAESKST GYSRRRQRKKSFILAKFYQSSYFGKLHVQHHPIM*" /label="ynfCn CDS" gene complement(1732820..1733230) /gene="ynfCn" /locus_tag="BSU_18110" /old_locus_tag="BSU18110" /pseudo /label="ynfCn gene" promotor_-10 complement(1733203..1733222) /Source="Nicolas_upshift_promotors" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1733206) /Source="Nicolas_upshifts" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1733237..1733244) /Source="Nicolas_upshift_promotors" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1733271..1733290) /Source="Nicolas_upshift_promotors" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1733272) /Source="Nicolas_upshifts" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1733305..1733312) /Source="Nicolas_upshift_promotors" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1733319..1733338) /Source="Nicolas_upshift_promotors" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1733330) /Source="Nicolas_upshifts" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1733352..1733361) /Source="Nicolas_upshift_promotors" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1733578..1733583 /Source="Nicolas_upshift_promotors" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1733596..1733615 /Source="Nicolas_upshift_promotors" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1733601 /Source="Nicolas_upshifts" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="upshifts" S_feature 1733614..1733678 /Source="Nicolas_S_feature" /locus_tag="new_1938860_1938924" /HighExp="Cold, G180, Oxctl, G135, LBGexp, G150, HPh, dia0, Lbexp, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S674" CDS 1733679..1735076 /gene="alsT" /locus_tag="BSU_18120" /old_locus_tag="BSU18120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8969507, 12823818, 15849754, 16850406, 22607086; Product type t : transporter" /codon_start=1 /transl_table=11 /product="H+/Na+:nitrogen-donor aminoacid symporter" /protein_id="NP_389694.1" /db_xref="EnsemblGenomes-Gn:BSU18120" /db_xref="EnsemblGenomes-Tr:CAB13695" /db_xref="GOA:Q45068" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG11798" /db_xref="UniProtKB/Swiss-Prot:Q45068" /translation="MESFFNSLINIPSDFIWKYLFYILIGLGLFFTIRFGFIQFRYFI EMFRIVGEKPEGNKGVSSMQAFFISAASRVGTGNLTGVALAIATGGPGAVFWMWVVAA VGMASSFVESTLAQLYKVRDGEDFRGGPAYYIQKGLGARWLGIVFAILITVSFGLIFN AVQTNTIAGALDGAFHVNKIVVAIVLAVLTAFIIFGGLKRVVAVSQLIVPVMAGIYIL IALFVVITNITAFPGVIATIVKNALGFEQVVGGGIGGIIVIGAQRGLFSNEAGMGSAP NAAATAHVSHPAKQGFIQTLGVFFDTFIICTSTAFIILLYSVTPKGDGIQVTQAALNH HIGGWAPTFIAVAMFLFAFSSVVGNYYYGETNIEFIKTSKTWLNIYRIAVIAMVVYGS LSGFQIVWDMADLFMGIMALINLIVIALLSNVAYKVYKDYAKQRKQGLDPVFKAKNIP GLKNAETWEDEKQEA*" /label="alsT CDS" gene 1733679..1735076 /gene="alsT" /locus_tag="BSU_18120" /old_locus_tag="BSU18120" /label="alsT gene" downshifts 1735065 /Source="Nicolas_upshifts" /id="D993" /incds=0 /nref=112 /ntot=203 /MaxReadThrough="3.44078" /MaxDrop="5.75319" /score="16.664707" /energy="-14.7" /TU="U1469" /idTUdmin="U1469" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" downshifts 1735110 /Source="Nicolas_upshifts" /id="D994" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.22962" /MaxDrop="5.03444" /score="16.664707" /energy="-14.7" /TU="NA" /idTUdmin="U1469" /TUdmin=22 /isTUend="TRUE" /label="downshifts" S_feature complement(1735166..1735912) /Source="Nicolas_S_feature" /locus_tag="new_1940412_1941158_c" /HighExp="S6, S8, S7, S5, BT, C30, B36, S4, LoTm, B60" /AntisenseName="eglS" /AntisenseCor="0.42607634596628102" /AntisenseRegPval="-12.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S675" promotor_-35 1735289..1735296 /Source="Nicolas_upshift_promotors" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1735308 /Source="Nicolas_upshifts" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1735309..1735328 /Source="Nicolas_upshift_promotors" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1735379..1736878 /gene="eglS" /locus_tag="BSU_18130" /old_locus_tag="BSU18130" /EC_number="3.2.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3024130, 7704256, 7710279, 15139916, 26907762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3024130, 7704256, 7710279, 15139916, 26907762; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-1,4-beta-glucanase" /protein_id="NP_389695.2" /db_xref="EnsemblGenomes-Gn:BSU18130" /db_xref="EnsemblGenomes-Tr:CAB13696" /db_xref="GOA:P10475" /db_xref="InterPro:IPR001547" /db_xref="InterPro:IPR001956" /db_xref="InterPro:IPR008965" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018087" /db_xref="InterPro:IPR036966" /db_xref="PDB:2L8A" /db_xref="PDB:3PZT" /db_xref="PDB:3PZU" /db_xref="PDB:3PZV" /db_xref="SubtiList:BG10437" /db_xref="UniProtKB/Swiss-Prot:P10475" /translation="MKRSISIFITCLLITLLTMGGMIASPASAAGTKTPVAKNGQLSI KGTQLVNRDGKAVQLKGISSHGLQWYGEYVNKDSLKWLRDDWGITVFRAAMYTADGGY IDNPSVKNKVKEAVEAAKELGIYVIIDWHILNDGNPNQNKEKAKEFFKEMSSLYGNTP NVIYEIANEPNGDVNWKRDIKPYAEEVISVIRKNDPDNIIIVGTGTWSQDVNDAADDQ LKDANVMYALHFYAGTHGQFLRDKANYALSKGAPIFVTEWGTSDASGNGGVFLDQSRE WLKYLDSKTISWVNWNLSDKQESSSALKPGASKTGGWRLSDLSASGTFVRENILGTKD STKDIPETPSKDKPTQENGISVQYRAGDGSMNSNQIRPQLQIKNNGNTTVDLKDVTAR YWYKAKNKGQNFDCDYAQIGCGNVTHKFVTLHKPKQGADTYLELGFKNGTLAPGASTG NIQLRLHNDDWSNYAQSGDYSFFKSNTFKTTKKITLYDQGKLIWGTEPN*" /label="eglS CDS" gene 1735379..1736878 /gene="eglS" /locus_tag="BSU_18130" /old_locus_tag="BSU18130" /label="eglS gene" promotor_-10 complement(1735911..1735930) /Source="Nicolas_upshift_promotors" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1735934) /Source="Nicolas_upshifts" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1735944..1735953) /Source="Nicolas_upshift_promotors" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1736826 /Source="Nicolas_upshifts" /id="D995" /incds=0 /nref=1 /ntot=89 /MaxReadThrough="3.59763" /MaxDrop="3.67571" /score="6.04626297" /energy="-10.7" /TU="NA" /idTUdmin="U1470" /TUdmin=1210 /isTUend="FALSE" /label="downshifts" CDS 1736946..1737209 /gene="ynfE" /locus_tag="BSU_18140" /old_locus_tag="BSU18140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389696.1" /db_xref="EnsemblGenomes-Gn:BSU18140" /db_xref="EnsemblGenomes-Tr:CAB13697" /db_xref="InterPro:IPR020302" /db_xref="SubtiList:BG11829" /db_xref="UniProtKB/Swiss-Prot:Q45069" /translation="MDEILKQYMVLYKKMSNMINGPDYPGKEKDIQHQKDQIEVYEKQ LQQGFSTDYDYDVFADSVIKCAYGDMTLEDLEAVYYGLTTPFF*" /label="ynfE CDS" gene 1736946..1737209 /gene="ynfE" /locus_tag="BSU_18140" /old_locus_tag="BSU18140" /label="ynfE gene" downshifts complement(1737468) /Source="Nicolas_upshifts" /id="D996" /incds=0 /nref=4 /ntot=148 /MaxReadThrough="1.78569" /MaxDrop="4.04338" /score="32.2414244" /energy="-12.6" /TU="NA" /idTUdmin="U1472" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(1737468..1738736) /gene="xynC" /locus_tag="BSU_18150" /old_locus_tag="BSU18150" /EC_number="3.2.1.136" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17028274, 25355936, 26559526, 28330222" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17028274, 25355936, 26559526, 28330222; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted endo-xylanase" /protein_id="NP_389697.1" /db_xref="EnsemblGenomes-Gn:BSU18150" /db_xref="EnsemblGenomes-Tr:CAB13698" /db_xref="GOA:Q45070" /db_xref="InterPro:IPR001139" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR033452" /db_xref="PDB:3GTN" /db_xref="PDB:3KL0" /db_xref="PDB:3KL3" /db_xref="PDB:3KL5" /db_xref="SubtiList:BG11830" /db_xref="UniProtKB/Swiss-Prot:Q45070" /translation="MIPRIKKTICVLLVCFTMLSVMLGPGATEVLAASDVTVNVSAEK QVIRGFGGMNHPAWAGDLTAAQRETAFGNGQNQLGFSILRIHVDENRNNWYKEVETAK SAVKHGAIVFASPWNPPSDMVETFNRNGDTSAKRLKYNKYAAYAQHLNDFVTFMKNNG VNLYAISVQNEPDYAHEWTWWTPQEILRFMRENAGSINARVIAPESFQYLKNLSDPIL NDPQALANMDILGTHLYGTQVSQFPYPLFKQKGAGKDLWMTEVYYPNSDTNSADRWPE ALDVSQHIHNAMVEGDFQAYVWWYIRRSYGPMKEDGTISKRGYNMAHFSKFVRPGYVR IDATKNPNANVYVSAYKGDNKVVIVAINKSNTGVNQNFVLQNGSASNVSRWITSSSSN LQPGTNLTVSGNHFWAHLPAQSVTTFVVNR*" /label="xynC CDS" gene complement(1737468..1738736) /gene="xynC" /locus_tag="BSU_18150" /old_locus_tag="BSU18150" /label="xynC gene" S_feature complement(1738737..1738866) /Source="Nicolas_S_feature" /locus_tag="new_1943983_1944112_c" /HighExp="Lbstat, BC, M0t90, LBGstat, Sw, T2.0H, M40t90, BI, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99419599999999997" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S676" CDS complement(1738867..1740408) /gene="xynD" /locus_tag="BSU_18160" /old_locus_tag="BSU18160" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1938968, 17426966, 26559526" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1938968, 17426966, 26559526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinoxylan arabinofuranohydrolase" /protein_id="NP_389698.1" /db_xref="EnsemblGenomes-Gn:BSU18160" /db_xref="EnsemblGenomes-Tr:CAB13699" /db_xref="GOA:Q45071" /db_xref="InterPro:IPR005084" /db_xref="InterPro:IPR006584" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR023296" /db_xref="PDB:3C7E" /db_xref="PDB:3C7F" /db_xref="PDB:3C7G" /db_xref="PDB:3C7H" /db_xref="PDB:3C7O" /db_xref="SubtiList:BG11807" /db_xref="UniProtKB/Swiss-Prot:Q45071" /translation="MRKKCSVCLWILVLLLSCLSGKSAYAATSTTIAKHIGNSNPLID HHLGADPVALTYNGRVYIYMSSDDYEYNSNGTIKDNSFANLNRVFVISSADMVNWTDH GAIPVAGANGANGGRGIAKWAGASWAPSIAVKKINGKDKFFLYFANSGGGIGVLTADS PIGPWTDPIGKPLVTPSTPGMSGVVWLFDPAVFVDDDGTGYLYAGGGVPGVSNPTQGQ WANPKTARVIKLGPDMTSVVGSASTIDAPFMFEDSGLHKYNGTYYYSYCINFGGTHPA DKPPGEIGYMTSSSPMGPFTYRGHFLKNPGAFFGGGGNNHHAVFNFKNEWYVVYHAQT VSSALFGAGKGYRSPHINKLVHNADGSIQEVAANYAGVTQISNLNPYNRVEAETFAWN GRILTEKSTAPGGPVNNQHVTSIQNGDWIAVGNADFGAGGARSFKANVASTLGGKIEV RLDSADGKLVGTLNVPSTGGAQTWREIETAVSGATGVHKVFFVFTGTGTGNLFNFDYW QFTQR*" /label="xynD CDS" gene complement(1738867..1740408) /gene="xynD" /locus_tag="BSU_18160" /old_locus_tag="BSU18160" /label="xynD gene" S_feature complement(1740409..1740730) /Source="Nicolas_S_feature" /locus_tag="new_1945655_1945976_c" /HighExp="M0t90, LBGstat, T1.30H, T2.30H, BC, M9-stat, T2.0H, T3.0H, T0.30H, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25588499999999997" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S677" promotor_-10 complement(1740720..1740739) /Source="Nicolas_upshift_promotors" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1740731) /Source="Nicolas_upshifts" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1740754..1740757) /Source="Nicolas_upshift_promotors" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1740957..1740964 /Source="Nicolas_upshift_promotors" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1740977..1740996 /Source="Nicolas_upshift_promotors" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1740984 /Source="Nicolas_upshifts" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1741003..1741449 /gene="yngA" /locus_tag="BSU_18170" /old_locus_tag="BSU18170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative conserved membrane protein possibly involved in arabinogalactan metabolism" /protein_id="NP_389699.1" /db_xref="EnsemblGenomes-Gn:BSU18170" /db_xref="EnsemblGenomes-Tr:CAB13700" /db_xref="GOA:O31821" /db_xref="InterPro:IPR007267" /db_xref="SubtiList:BG13452" /db_xref="UniProtKB/Swiss-Prot:O31821" /translation="MTATRIFYEGRFVTLKEKIKTLGRFCTVGVGNTLIDFGVFFLLT ACHVSYLPAQICSYTAGIVNSYVWNRNWTFCVKRKADGKEIVRFLMINIAASGITFLL LYLFQNCGCSLLVSKLAATIGGMMMNFIGNRIWVFGDSLKNIQDQE*" /label="yngA CDS" gene 1741003..1741449 /gene="yngA" /locus_tag="BSU_18170" /old_locus_tag="BSU18170" /label="yngA gene" CDS 1741456..1742349 /gene="yngB" /locus_tag="BSU_18180" /old_locus_tag="BSU18180" /EC_number="2.7.7.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8320212, 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_389700.1" /db_xref="EnsemblGenomes-Gn:BSU18180" /db_xref="EnsemblGenomes-Tr:CAB13701" /db_xref="GOA:O31822" /db_xref="InterPro:IPR005771" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13453" /db_xref="UniProtKB/Swiss-Prot:O31822" /translation="MRKKVRKAVIPAAGLGTRFLPATKAQPKEMLPIVDKPAIQYIVE EAAESGIEDILIITGRNKRSIEDHFDRSAELEFNLREKGKTETLKEMQQIADLANIHY IRQKEPLGLGHAVLCAEHFIGDEPFAVLLGDDIMVSETPALRQLMDVYDVYGTEVVGV QSVLPEDVSKYGIINTSGSQGHVYEVNDLVEKPSPEEAPSEIAVMGRYVLNSSIFSVL KTIGRGAGNEIQLTDALREVCRKEPIHARLLEGNRYDIGDKLGCFKASTEIGLMRPEM RSQLLAYLEDVIKRETKEMLR*" /label="yngB CDS" gene 1741456..1742349 /gene="yngB" /locus_tag="BSU_18180" /old_locus_tag="BSU18180" /label="yngB gene" misc_feature 1741966..1741985 /Source="Nicolas_upshift_promotors" /id="U1474" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2146 /SigmaFactorBS="tggcacagaggttgtcggtgtacagtcagttctccctgagga tgtcagcaaaTATGGTATTATAAATACATCagggtctcaagggcatgtatatgaagtg a" /listShort="yngC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1741974 /Source="Nicolas_upshifts" /id="U1474" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2146 /SigmaFactorBS="tggcacagaggttgtcggtgtacagtcagttctccctgagga tgtcagcaaaTATGGTATTATAAATACATCagggtctcaagggcatgtatatgaagtg a" /listShort="yngC" /GFF_Attribute="listLong" /label="upshifts" CDS 1742422..1743018 /gene="yngC" /locus_tag="BSU_18190" /old_locus_tag="BSU18190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein, phosphatase or phosphate isomerase" /protein_id="NP_389701.1" /db_xref="EnsemblGenomes-Gn:BSU18190" /db_xref="EnsemblGenomes-Tr:CAB13702" /db_xref="GOA:O31823" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13454" /db_xref="UniProtKB/Swiss-Prot:O31823" /translation="MGSLISEILTWLTNMGYAGIAIGLMIEIIPSEIVLAYGGYMVSE GTIGFIGAIIAGVIGGTIAQIFIYWIGRYGGRPFLDKYGKYLLIKKHHIDMSENWFQK YGAGVVFSARFIPVVRHAISIPAGIARMPFLKFVVLTVLAIIPWSILFVYLGIQLGSQ WDDVENIAGTYTTPIMILAVVVIALYFVIKKRTAIFKR*" /label="yngC CDS" gene 1742422..1743018 /gene="yngC" /locus_tag="BSU_18190" /old_locus_tag="BSU18190" /label="yngC gene" downshifts 1743008 /Source="Nicolas_upshifts" /id="D997" /incds=0 /nref=191 /ntot=259 /MaxReadThrough="1.94273" /MaxDrop="5.58345" /score="15.4353025" /energy="-15" /TU="NA" /idTUdmin="U1474" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1743067..1744266) /gene="nrnB" /locus_tag="BSU_18200" /old_locus_tag="BSU18200" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19553197, 22262096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19553197, 22262096; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligoribonuclease (nanoRNase)" /protein_id="NP_389702.1" /db_xref="EnsemblGenomes-Gn:BSU18200" /db_xref="EnsemblGenomes-Tr:CAB13703" /db_xref="GOA:O31824" /db_xref="SubtiList:BG13455" /db_xref="UniProtKB/Swiss-Prot:O31824" /translation="MYHLYSHNDLDGVGCGIVAKLAFGKDVEIRYNSVNGLNAQVQYF LEKAKESNRQDALFITDLAVNEENEERLNEYVHAGGKVKLIDHHKTALHLNEHEWGFV QVEYDDGRLTSATSLLYGYLIENGFMKPTNALDQFTELVRQYDTWEWERYDQKQAKRL NDLFFLLSIDEFEAKMIQRLSTHDEFFFDDFEEKLLDLEDEKIERYLRRKKREMVQTF VHEHCVGIVHAESYHSELGNRLGKDNPHLDYIAILSMGSKRVSLRTIHDYIDVSEIAG RYGGGGHAKASGCSITDEVYELFVAEAFRIDPVRPDAFRNIYNLKGSANGSLYENRAQ MRFFLFPLDNEWNIQINGETQDETFAAFEEAEWFIKRNYAASLVRDEVFVAFLAENLK LANQHRK*" /label="nrnB CDS" gene complement(1743067..1744266) /gene="nrnB" /locus_tag="BSU_18200" /old_locus_tag="BSU18200" /label="nrnB gene" S_feature complement(1744267..1744338) /Source="Nicolas_S_feature" /locus_tag="new_1949513_1949584_c" /HighExp="S5, S7, S4, S8, S6, ferm, nit, LBGstat, T5.0H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.977" /TUlongSig="NA" /TUlongPSig="NA" /label="S678" promotor_-10 complement(1744326..1744337) /Source="Nicolas_upshift_promotors" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1744338) /Source="Nicolas_upshifts" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1744352..1744358) /Source="Nicolas_upshift_promotors" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1744436..1745971) /gene="ldeE" /locus_tag="BSU_18210" /old_locus_tag="BSU18210" /EC_number="6.4.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylcrotonoyl-CoA carboxylase subunit (leucinedegradation)" /protein_id="NP_389703.2" /db_xref="EnsemblGenomes-Gn:BSU18210" /db_xref="EnsemblGenomes-Tr:CAB13704" /db_xref="GOA:O31825" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG13456" /db_xref="UniProtKB/Swiss-Prot:O31825" /translation="MLMDYEKERTERAERIRKGGAEKYHQSNREKGKLFVRERLSLLF DDDIELEDAFFAECMSDGLPADGVVTAIGKIGGQTVCVMANDSTVKAGSWGAKTVEKI IRIQEIAEKLNCPLIYLVDSAGARITDQINVFPGRRGAGRIFYNQVKLSGRIPQICLL FGPSAAGGAYIPAFCDIVVMVDGNASMYLGSPRMAEMVIGEKVSLEEMGGARMHCSIS GCGDILAETEEEAIQLVRAYLSYFPANFQEKAPIHEKRPPKHFETPLADVIPQNQNAP FDMHELIERVIDEDSFFEIKALFAPELLTGLARIHGQPVGIVANQPKVKGGVLFHDSA DKAAKFITLCDAFHIPLLFLADIPGFMIGTKVEQAGIIRHGAKMISAMSEATVPKLSV IVRKAYGAGLYAMAGPAFEPDCCLALPTAQIAVMGPEAAVNAVYAKKIAELPEEERAA FISSKREEYKEDINIYRLASEMIIDAVIPANSLRDELAKRLKAYMTKEMTFTNRKHPV YPV*" /label="ldeE CDS" gene complement(1744436..1745971) /gene="ldeE" /locus_tag="BSU_18210" /old_locus_tag="BSU18210" /label="ldeE gene" downshifts complement(1744448) /Source="Nicolas_upshifts" /id="D998" /incds=0 /nref=18 /ntot=38 /MaxReadThrough="1.74923" /MaxDrop="5.31437" /score="-1.4478995" /energy="-11.8" /TU="NA" /idTUdmin="U1477" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1745982..1746764) /gene="ldeF" /locus_tag="BSU_18220" /old_locus_tag="BSU18220" /EC_number="4.2.1.18" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglutaconyl-CoA hydratase (leucine degradation)" /protein_id="NP_389704.1" /db_xref="EnsemblGenomes-Gn:BSU18220" /db_xref="EnsemblGenomes-Tr:CAB13705" /db_xref="GOA:O34893" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG13457" /db_xref="UniProtKB/Swiss-Prot:O34893" /translation="MGDSILFTVKNEHMALITLNRPQAANALSAEMLRNLQMIIQEIE FNSNIRCVILTGTGEKAFCAGADLKERIKLKEDQVLESVSLIQRTAALLDALPQPVIA AINGSALGGGLELALACDLRIATEAAVLGLPETGLAIIPGAGGTQRLPRLIGRGKAKE FIYTGRRVTAHEAKEIGLVEHVTAPCDLMPKAEELAAAISANGPIAVRQAKFAINKGL ETDLATGLAIEQKAYEQTIPTKDRREGLQAFQEKRRAVYKGI*" /label="ldeF CDS" gene complement(1745982..1746764) /gene="ldeF" /locus_tag="BSU_18220" /old_locus_tag="BSU18220" /label="ldeF gene" CDS complement(1746785..1747684) /gene="ldeG" /locus_tag="BSU_18230" /old_locus_tag="BSU18230" /EC_number="4.1.3.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 16330546, 19935659, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroxymethylglutaryl-CoA lyase (leucine degradation)" /protein_id="NP_389705.1" /db_xref="EnsemblGenomes-Gn:BSU18230" /db_xref="EnsemblGenomes-Tr:CAB13706" /db_xref="GOA:O34873" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR013785" /db_xref="PDB:1YDO" /db_xref="SubtiList:BG13458" /db_xref="UniProtKB/Swiss-Prot:O34873" /translation="MPYPKKVTIKEVGPRDGLQNEPVWIATEDKITWINQLSRTGLSY IEITSFVHPKWIPALRDAIDVAKGIDREKGVTYAALVPNQRGLENALEGGINEACVFM SASETHNRKNINKSTSESLHILKQVNNDAQKANLTTRAYLSTVFGCPYEKDVPIEQVI RLSEALFEFGISELSLGDTIGAANPAQVETVLEALLARFPANQIALHFHDTRGTALAN MVTALQMGITVFDGSAGGLGGCPYAPGSSGNAATEDIVYMLEQMDIKTNVKLEKLLSA AKWIEEKMGKPLPSRNLQVFKSS*" /label="ldeG CDS" gene complement(1746785..1747684) /gene="ldeG" /locus_tag="BSU_18230" /old_locus_tag="BSU18230" /label="ldeG gene" CDS complement(1747699..1747920) /gene="lgeHB" /locus_tag="BSU_18239" /old_locus_tag="BSU18239" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type c: carrier" /codon_start=1 /transl_table=11 /product="methylcrotonyl-CoA carboxylase; biotinylated subunit (leucine degradation)" /protein_id="YP_003097733.1" /db_xref="EnsemblGenomes-Gn:BSU18239" /db_xref="EnsemblGenomes-Tr:CAX52627" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR011053" /db_xref="PDB:1Z6H" /db_xref="PDB:1Z7T" /db_xref="PDB:2B8F" /db_xref="PDB:2B8G" /db_xref="UniProtKB/Swiss-Prot:C0H419" /translation="MTVSIQMAGNLWKVHVKAGDQIEKGQEVAILESMKMEIPIVADR SGIVKEVKKKEGDFVNEGDVLLELSNSTQ*" /label="lgeHB CDS" gene complement(1747699..1747920) /gene="lgeHB" /locus_tag="BSU_18239" /old_locus_tag="BSU18239" /label="lgeHB gene" CDS complement(1747935..1749269) /gene="ldeHA" /locus_tag="BSU_18240" /old_locus_tag="BSU18240" /EC_number="6.4.1.4" /EC_number="6.3.4.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7915138, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin carboxylase for subunit LdeHB of methylcrotonyl-CoA carboxylase" /protein_id="NP_389706.1" /db_xref="EnsemblGenomes-Gn:BSU18240" /db_xref="EnsemblGenomes-Tr:CAB13707" /db_xref="GOA:O34544" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG13459" /db_xref="UniProtKB/Swiss-Prot:O34544" /translation="MFTKVLIANRGEIAMRIIRTCSRLGIKTVAVYSEADKDAPHTKA ATEAYLIGESRVSESYLNIERIIKTAKKAKADAIHPGYGLLSENSRFAERCKQENIVF IGPSPDIIAKMGSKIEARKAMEAAGVPVVPGVSESLGDIEAACRTASQIGYPVMLKAS AGGGGIGMQRVENEEALKKAYEGNKKRAADFFGDGSMYIEKVIEHARHIEVQLLADQH GHTVHLFERDCSVQRRHQKVIEEAPSPFVDDELRMKIGQTAVKAAKAIGYTNAGTIEF IVDQKQNFYFLEMNTRLQVEHPVTEEITGLDLVEQQLRIAAGHTLTFSQKDIQRNGHA IEVRIYAEDPKTFFPSPGTITAFSLPDQKGVRHECAVAKDSTVTPFYDPMIAKMIVKG QTRTEAIEKLETALRDYRVEGIKTNLPLLIQAAATKAFKEGDVTTDFLKQHL*" /label="ldeHA CDS" gene complement(1747935..1749269) /gene="ldeHA" /locus_tag="BSU_18240" /old_locus_tag="BSU18240" /label="ldeHA gene" CDS complement(1749279..1750928) /gene="ldeI" /locus_tag="BSU_18250" /old_locus_tag="BSU18250" /EC_number="6.2.1.16" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12535077, 15213221, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl-CoA synthetase" /protein_id="NP_389707.1" /db_xref="EnsemblGenomes-Gn:BSU18250" /db_xref="EnsemblGenomes-Tr:CAB13708" /db_xref="GOA:O31826" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13460" /db_xref="UniProtKB/Swiss-Prot:O31826" /translation="MAELIHSTIGRLLEQTADAYPDRDAVVYPDRNIRYTYAQFDSLC RQTAKGLMRMGIGKGDHVAIWASNISEWLAVQFATAKIGAVLVTVNTNYQAHELDYLL KQSDAAALIIMDSYRGTSYPDIVNSLIPELQEAKPGQLKSERYPFLKTLIYIGNKRLS GMYHWDDTEILAKTVTDAELEERMNSLDKDNVINMQYTSGTTGFPKGVMLTHFNVINN AANIAECMALTSQDRMCIPVPFFHCFGCVLGVLACVSVGAAMIPVQEFDPVTVLKTVE KEKCTVLHGVPTMFIAELHHPDFDAYDLSTLRTGIMAGSPCPSEVMKAVIERMGMKDI TIAYGQTEASPVITQTRANDSFIRRVETTGRALPHTEVKIVEPGTCQEVQRGMQGELC TRGYHVMKGYYKDKDATRKAINHDGWLFTGDLAVMDEDGYCRITGRLKDMLIRGGENI YPREIEEFLYQHPAVLDVQVVGVPDAKFGEEAAAWIKLKDGKSVSPDELKAYCKGKIA RHKIPRYVIFTDDYPMTASGKIQKYKLREKTIEMFNLSSSQ*" /label="ldeI CDS" gene complement(1749279..1750928) /gene="ldeI" /locus_tag="BSU_18250" /old_locus_tag="BSU18250" /label="ldeI gene" promotor_no_box 1749328..1749428 /Source="Nicolas_upshift_promotors" /id="U1476" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.287712287712288" /psig="0.174825174825175" /xcortree=1695 /SigmaFactorBS="ttatatttttgaattttgcctgaggccgtcatcggatagtca tccgtaaaaataacataacgcggaattttgtggcgggcgattttccctttgcaatagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1749388 /Source="Nicolas_upshifts" /id="U1476" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.287712287712288" /psig="0.174825174825175" /xcortree=1695 /SigmaFactorBS="ttatatttttgaattttgcctgaggccgtcatcggatagtca tccgtaaaaataacataacgcggaattttgtggcgggcgattttccctttgcaatagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1750972..1752114) /gene="ldeJ" /locus_tag="BSU_18260" /old_locus_tag="BSU18260" /EC_number="1.3.8.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8655474, 17085570, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isovaleryl-CoA dehydrogenase (leucine degradation)" /protein_id="NP_389708.1" /db_xref="EnsemblGenomes-Gn:BSU18260" /db_xref="EnsemblGenomes-Tr:CAB13709" /db_xref="GOA:O34421" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG13461" /db_xref="UniProtKB/Swiss-Prot:O34421" /translation="MNFELTKEQQMVREMVKDFAKKEIAPHAEHVDQTGEFPMQTFKK MGELGLMGIPFPEEYGGSGGDTISYALAVEEVGKACGSTGLSYAAAVSLGASPLYYFG TEEQKQTHLTPLASGTALGSFGLTEPNAGSDAGGTQTKAISNGDEYVINGEKCWITNA SYARTVIVTAVTGKNKDGKNIISALIVPTDTPGLTITSPYDKMGVRGSNTAEILLEDV RVPAANLLGDPTKGFKQFLYTLDGGRISIAALAVGIAQAALDASLAYAKERKQFGQPI SSFQAIQFKLADMAMEIDLARQMVLKAAWLKDHNRPFTKEAAYAKLFASEMATRACNQ AIQIHGGSGYMKEYGVERMLRDAKLMEIGEGTSEIQRLVIARQLLK*" /label="ldeJ CDS" gene complement(1750972..1752114) /gene="ldeJ" /locus_tag="BSU_18260" /old_locus_tag="BSU18260" /label="ldeJ gene" promotor_-10 complement(1752133..1752151) /Source="Nicolas_upshift_promotors" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1752150) /Source="Nicolas_upshifts" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1752167..1752172) /Source="Nicolas_upshift_promotors" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1752205..1752510) /gene="ynzE" /locus_tag="BSU_18270" /old_locus_tag="BSU18270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389709.1" /db_xref="EnsemblGenomes-Gn:BSU18270" /db_xref="EnsemblGenomes-Tr:CAB13710" /db_xref="GOA:O34356" /db_xref="InterPro:IPR020509" /db_xref="SubtiList:BG13468" /db_xref="UniProtKB/Swiss-Prot:O34356" /translation="MLTDPAEEAFLPNFLLLGAGTALVLCLVFFLYQKLDQSQFAVIK LGIWGSAVGLLMDTISLWNLPLIFPALSKGQVIAFTIWMVCAYCMYLLIPLILSHKK* " /label="ynzE CDS" gene complement(1752205..1752510) /gene="ynzE" /locus_tag="BSU_18270" /old_locus_tag="BSU18270" /label="ynzE gene" CDS complement(1752500..1752673) /locus_tag="BSU_18275" /old_locus_tag="BSU18275" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513961.1" /translation="MNMEAVFGHLPLLESEKLVLNKNKIEEKHVQDVFYVFISSLVRC HIIFCAVRRCCVD*" /label="conserved protein of unknown function CDS" gene complement(1752500..1752673) /locus_tag="BSU_18275" /old_locus_tag="BSU18275" /label="gene" CDS complement(1752781..1754313) /gene="yngK" /locus_tag="BSU_18280" /old_locus_tag="BSU18280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative exported glycoside hydrolase" /protein_id="NP_389710.1" /db_xref="EnsemblGenomes-Gn:BSU18280" /db_xref="EnsemblGenomes-Tr:CAB13711" /db_xref="InterPro:IPR003790" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG13462" /db_xref="UniProtKB/Swiss-Prot:O35015" /translation="MKVCQKSIVRFLVSLIIGTFVISVPFMANAQSDRELRAVWIASV LNIDWPSKKGLSVKEQKQEYIKLLDDVQKMGMNAVIVQIKPTADAFYPSAYGPWSEYL TGVQGKDPGYDPLAFMIEETHKRNLEFHAWFNPYRITMNHTDLNKLSEDHPARKHPDW VAAYGNQLYYHPGIPEARDFIVKGIEEVVKHYDIDAVHMDDYFYPYKIAGQEFPDQAQ YEQYGKDAFSNIDDWRRDNVNQLVKQINQTIKAAKPYVKFGISPFGVWRNAADDPTGS NTKAGVRNYDDLYADTRHWIQEGDIDYIAPQIYWSIGFNAAAYDVLADWWSNEVKNRP VHLYIGQAAYKINNNFDPPWSDPEEYVRQITLNRQLELVKGSMHFSLKDLNKNPLGIK DSLSTDLYSKPALVPQMPWLDNTAPKKPKLTKVTEDKNGNLLQIKDHPSNQKTKETAY YAIYRAEGKKQRTLLATQRKTHEQQTFLDNTADPNKKYTYYVTSADRLHNESKASKRT TK*" /label="yngK CDS" gene complement(1752781..1754313) /gene="yngK" /locus_tag="BSU_18280" /old_locus_tag="BSU18280" /label="yngK gene" downshifts complement(1752792) /Source="Nicolas_upshifts" /id="D999" /incds=0 /nref=7 /ntot=27 /MaxReadThrough="2.27934" /MaxDrop="4.41371" /score="9.43133612" /energy="-8" /TU="NA" /idTUdmin="U1478" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1754348..1754367) /Source="Nicolas_upshift_promotors" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1754348) /Source="Nicolas_upshifts" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1754380..1754389) /Source="Nicolas_upshift_promotors" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1754449..1754841) /gene="yngL" /locus_tag="BSU_18290" /old_locus_tag="BSU18290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 28163698; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389711.1" /db_xref="EnsemblGenomes-Gn:BSU18290" /db_xref="EnsemblGenomes-Tr:CAB13712" /db_xref="GOA:O34506" /db_xref="InterPro:IPR010773" /db_xref="SubtiList:BG13463" /db_xref="UniProtKB/Swiss-Prot:O34506" /translation="MDRLSFLTFIMLILASYRLTHLIVFDKITEFIRKPFMKKKRIVD QNGHVDEKSVPASNFGYMLNCYWCAGVWCAILIGLGYLFLPRIAIPLIFILAIAGAQA ILETAVGVGVKLIDVLKSLQTMMNDKKS*" /label="yngL CDS" gene complement(1754449..1754841) /gene="yngL" /locus_tag="BSU_18290" /old_locus_tag="BSU18290" /label="yngL gene" downshifts complement(1754480) /Source="Nicolas_upshifts" /id="D1000" /incds=0 /nref=2 /ntot=18 /MaxReadThrough="0.581539999999999" /MaxDrop="2.96298" /score="5.25915686" /energy="-11.4" /TU="NA" /idTUdmin="U1479" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1754869..1754880) /Source="Nicolas_upshift_promotors" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1754876) /Source="Nicolas_upshifts" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1754894..1754900) /Source="Nicolas_upshift_promotors" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="promotor_-35" SCAR join(1754948,1754955) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs10" N_region 1754949..1754954 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs10" S_feature complement(<1754955..1755060) /Source="Nicolas_S_feature" /locus_tag="new_1997958_1998066_c" /HighExp="T1.30H, T1.0H, T0.30H, S1, M0t90, T2.30H, LPhT, C90, LoTm, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S679" promotor_-10 complement(1755045..1755064) /Source="Nicolas_upshift_promotors" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1755060) /Source="Nicolas_upshifts" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1755078..1755085) /Source="Nicolas_upshift_promotors" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1755334..1756809) /gene="dacC" /locus_tag="BSU_18350" /old_locus_tag="BSU18350" /EC_number="3.4.16.4" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9733705, 9864321, 11160090, 14731276, 17582436, 19758330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733705, 9864321, 11160090, 14731276, 17582436, 19758330; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase" /protein_id="NP_389717.1" /db_xref="EnsemblGenomes-Gn:BSU18350" /db_xref="EnsemblGenomes-Tr:CAB13718" /db_xref="GOA:P39844" /db_xref="InterPro:IPR000667" /db_xref="InterPro:IPR012338" /db_xref="PDB:1W5D" /db_xref="PDB:2J9P" /db_xref="SubtiList:BG10969" /db_xref="UniProtKB/Swiss-Prot:P39844" /translation="MKKSIKLYVAVLLLFVVASVPYMHQAALAAEKQDALSGQIDKIL ADHPALEGAMAGITVRSAETGAVLYEHSGDTRMRPASSLKLLTAAAALSVLGENYSFT TEVRTDGTLKGKKLNGNLYLKGKGDPTLLPSDFDKMAEILKHSGVKVIKGNLIGDDTW HDDMRLSPDMPWSDEYTYYGAPISALTASPNEDYDAGTVIVEVTPNQKEGEEPAVSVS PKTDYITIKNDAKTTAAGSEKDLTIEREHGTNTITIEGSVPVDANKTKEWISVWEPAG YALDLFKQSLKKQGITVKGDIKTGEAPSSSDVLLSHRSMPLSKLFVPFMKLSNNGHAE VLVKEMGKVKKGEGSWEKGLEVLNSTLPEFGVDSKSLVLRDGSGISHIDAVSSDQLSQ LLYDIQDQSWFSAYLNSLPVAGNPDRMVGGTLRNRMKGTPAQGKVRAKTGSLSTVSSL SGYAETKSGKKLVFSILLNGLIDEEDGKDIEDQIAVILANQ*" /label="dacC CDS" gene complement(1755334..1756809) /gene="dacC" /locus_tag="BSU_18350" /old_locus_tag="BSU18350" /label="dacC gene" downshifts complement(1755346) /Source="Nicolas_upshifts" /id="D1003" /incds=0 /nref=126 /ntot=224 /MaxReadThrough="1.56173" /MaxDrop="5.81468" /score="20.5621533" /energy="-10.2" /TU="NA" /idTUdmin="U1484" /TUdmin="-16" /isTUend="TRUE" /label="downshifts" CDS complement(1756843..1757820) /gene="galM" /locus_tag="BSU_18360" /old_locus_tag="BSU18360" /EC_number="5.1.3.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9733705, 12753898, 19758330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733705, 12753898, 19758330; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aldose 1-epimerase" /protein_id="NP_389718.1" /db_xref="EnsemblGenomes-Gn:BSU18360" /db_xref="EnsemblGenomes-Tr:CAB13719" /db_xref="GOA:P39840" /db_xref="InterPro:IPR008183" /db_xref="InterPro:IPR011013" /db_xref="InterPro:IPR014718" /db_xref="PDB:3MWX" /db_xref="PDB:4BZE" /db_xref="PDB:4BZF" /db_xref="PDB:4BZG" /db_xref="PDB:4BZH" /db_xref="SubtiList:BG10253" /db_xref="UniProtKB/Swiss-Prot:P39840" /translation="MANFIEKITYLGTPAIKAGNEHLEMIVVPEWGSNVISLVDKTTN VQLLREPETAESFHDTPTLYGIPILFPPNRISDGTFSFRGRTYHFDINEKDKHNHLHG FLYHEKWNVVTTKQTDEGVIVETEIDLSELPHVQKQFPHHAVVRMTYTIKENTLFKHA TVMNKGKEAFPWGIGYHTTFIFPAESSLFSLTADQQWELDERLLPTGKLMDVPYKEAL HEGMDLRHKQLDDVFLSSYQKRGGENQAVIYHQHAHISIIYKADEQFKHWVVYNADGK QGYLCPEPYTWVTNAVNLDLPSSLTGLQVLEPGEETTAKSSITIELNHQ*" /label="galM CDS" gene complement(1756843..1757820) /gene="galM" /locus_tag="BSU_18360" /old_locus_tag="BSU18360" /label="galM gene" promotor_-10 complement(1757849..1757867) /Source="Nicolas_upshift_promotors" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1757861) /Source="Nicolas_upshifts" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1757879..1757887) /Source="Nicolas_upshift_promotors" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1757954..1759345) /gene="yoeA" /locus_tag="BSU_18370" /old_locus_tag="BSU18370" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 28472044; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+-driven efflux transporter" /protein_id="NP_389719.2" /db_xref="EnsemblGenomes-Gn:BSU18370" /db_xref="EnsemblGenomes-Tr:CAB13720" /db_xref="GOA:O34474" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG13548" /db_xref="UniProtKB/Swiss-Prot:O34474" /translation="METSQEPLVTQKKSKPSVWRSMSLFLVPLLLSNVLQSVGQLVGM MAVGRWLGVDAVAAVSSFFPLFFLLISFTIGIGSGSSILIGQAYGAKNEERLKAVVGT TLTFTFLLGVVLAVIGSIFTLDILRLMGTPENVIHVSANYARILFYAMPFMFLYFAYT TFLRGTGDSKTPFYTLIVSTVINIALLPVLILGMFGFPKLGIYGSAYATVISTIATFL VLMVYLRKRKHPLQFDKTVRRYLKMDKELLVLLLRLGVPASINMILVSLSEIAVISFV NHYGSNATAAYGVVNQVASYVQMPAVSLGIAVSIFAAQSIGANEFDRLKQVIRVGIWL NYIIGGVLIILIYVFSHQILSLFLTEQETLYIAHRLLMITLWSYLLFGNAQIISATMR ASGTVLWPTVISIFAIWGVEVPVAFVLSHYTKLEILGVWVGYPAAFAVSLLLIYGYYQ FVWKKKQITRLIQ*" /label="yoeA CDS" gene complement(1757954..1759345) /gene="yoeA" /locus_tag="BSU_18370" /old_locus_tag="BSU18370" /label="yoeA gene" downshifts complement(1757968) /Source="Nicolas_upshifts" /id="D1004" /incds=0 /nref=74 /ntot=213 /MaxReadThrough="2.12119" /MaxDrop="5.14152" /score="31.8413544" /energy="-12.3" /TU="NA" /idTUdmin="U1486" /TUdmin=2 /isTUend="TRUE" /label="downshifts" downshifts 1758114 /Source="Nicolas_upshifts" /id="D1005" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="1.76262" /MaxDrop="3.63403" /score="24.8192541" /energy="-9.3" /TU="NA" /idTUdmin="U1485" /TUdmin="-1452" /isTUend="FALSE" /label="downshifts" promotor_-35 1759135..1759141 /Source="Nicolas_upshift_promotors" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="promotor_-35" promotor_-10 1759155..1759173 /Source="Nicolas_upshift_promotors" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="promotor_-10" S_feature 1759166..1759499 /Source="Nicolas_S_feature" /locus_tag="new_2002172_2002505" /HighExp="M9-stat, Etha, Gly, S8, Sw, S7, B60, S6, Salt, C30" /AntisenseName="yoeA" /AntisenseCor="9.0133358617756607E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S680" upshifts 1759166 /Source="Nicolas_upshifts" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="upshifts" S_feature complement(1759346..1759450) /Source="Nicolas_S_feature" /locus_tag="new_2002352_2002456_c" /HighExp="S8, LBGstat, Etha, Cold, S7, T-1.40H, S2, C90, nit, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.456" /TUlongSig="NA" /TUlongPSig="NA" /label="S681" promotor_no_box complement(1759410..1759510) /Source="Nicolas_upshift_promotors" /id="U1486" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.455544455544456" /psig="0.455544455544456" /xcortree=562 /SigmaFactorBS="ttacttgctagtttattcttcataagctaaaaagatgtgtaa aattagaagaatcgggaagggtttcataagtgcagtgatgaataataacatgttacat a" /listShort="S681, yoeA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1759450) /Source="Nicolas_upshifts" /id="U1486" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.455544455544456" /psig="0.455544455544456" /xcortree=562 /SigmaFactorBS="ttacttgctagtttattcttcataagctaaaaagatgtgtaa aattagaagaatcgggaagggtttcataagtgcagtgatgaataataacatgttacat a" /listShort="S681, yoeA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1759472..1759477 /Source="Nicolas_upshift_promotors" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1759493..1759511 /Source="Nicolas_upshift_promotors" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1759501 /Source="Nicolas_upshifts" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1759559..1759566 /Source="Nicolas_upshift_promotors" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1759579..1759598 /Source="Nicolas_upshift_promotors" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1759582 /Source="Nicolas_upshifts" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="upshifts" CDS 1759631..1760176 /gene="iseA" /locus_tag="BSU_18380" /old_locus_tag="BSU18380" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17483219, 17581128, 18761694, 22720735, 23091053" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17483219, 17581128, 18761694, 22720735, 23091053; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of DL-endopeptidases involved in cell-separation" /protein_id="NP_389720.2" /db_xref="EnsemblGenomes-Gn:BSU18380" /db_xref="EnsemblGenomes-Tr:CAB13721" /db_xref="InterPro:IPR031841" /db_xref="PDB:2RSX" /db_xref="SubtiList:BG13549" /db_xref="UniProtKB/Swiss-Prot:O34841" /translation="MKKCLLFLTTIALILSLSTNAFAKNTSGDLSQKQALQLALSARE HFWNTMSGHNPKVKKAVCPSGTFEYQNLQYVYMCSDLGTKAKAVNYLTPIFTKTAIEK GFKDYHFTVSKGKLAVPIGDGDNLLNWKKSTAKLISKKGSTITYEFTVPTLDGSPSAK RKVTFVKENKKWKVNQFDAVI*" /label="iseA CDS" gene 1759631..1760176 /gene="iseA" /locus_tag="BSU_18380" /old_locus_tag="BSU18380" /label="iseA gene" downshifts 1760160 /Source="Nicolas_upshifts" /id="D1006" /incds=0 /nref=164 /ntot=264 /MaxReadThrough="4.38689" /MaxDrop="8.27665" /score="24.8192541" /energy="-9.3" /TU="NA" /idTUdmin="U1487" /TUdmin=0 /isTUend="TRUE" /label="downshifts" tRNA complement(1760270..1760342) /gene="trnSL-Arg1" /locus_tag="BSU_tRNA_85" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Arg1 tRNA" gene complement(1760270..1760342) /gene="trnSL-Arg1" /locus_tag="BSU_tRNA_85" /label="trnSL-Arg1 gene" downshifts complement(1760368) /Source="Nicolas_upshifts" /id="D1007" /incds=0 /nref=4 /ntot=118 /MaxReadThrough="1.99821" /MaxDrop="3.03097" /score="3.94141467" /energy="-15.1" /TU="NA" /idTUdmin="U1489" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1760395..1760940) /gene="yoeC" /locus_tag="BSU_18390" /old_locus_tag="BSU18390" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bacteriophage integrase" /protein_id="NP_389721.2" /db_xref="EnsemblGenomes-Gn:BSU18390" /db_xref="EnsemblGenomes-Tr:CAB13722" /db_xref="GOA:O35009" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR013762" /db_xref="SubtiList:BG13550" /db_xref="UniProtKB/Swiss-Prot:O35009" /translation="MHIVQPIRSLEKIQEVKQYLLNKNKRDYFLFIFGINSALRISDI LPLQVKDVQNKDHLWATESKTKKKRKILILESLKQEIYEYTKDMKENEYLFKSVRTRK PISRIQAYRILREAAAACGLEEIGTHTLRKTFGYHFYQRTKDIAELQRILNHSSPSIT MRYIGIDEDTTRAAYKVFGGL*" /label="yoeC CDS" gene complement(1760395..1760940) /gene="yoeC" /locus_tag="BSU_18390" /old_locus_tag="BSU18390" /label="yoeC gene" promotor_-10 complement(1760980..1760999) /Source="Nicolas_upshift_promotors" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1760994) /Source="Nicolas_upshifts" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1761013..1761020) /Source="Nicolas_upshift_promotors" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1761256..1761486) /gene="yoeD" /locus_tag="BSU_18400" /old_locus_tag="BSU18400" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16880568; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative excisionase" /protein_id="NP_389722.1" /db_xref="EnsemblGenomes-Gn:BSU18400" /db_xref="EnsemblGenomes-Tr:CAB13723" /db_xref="GOA:O34555" /db_xref="InterPro:IPR010093" /db_xref="SubtiList:BG13551" /db_xref="UniProtKB/Swiss-Prot:O34555" /translation="MYLTIEETAEYTNLSEDYIKSLVLEGKIRAVHDGEQFLIYKEQF KTHLEQLENYKALVQEILNEPIPEDIDVKDED*" /label="yoeD CDS" gene complement(1761256..1761486) /gene="yoeD" /locus_tag="BSU_18400" /old_locus_tag="BSU18400" /label="yoeD gene" downshifts complement(1761270) /Source="Nicolas_upshifts" /id="D1008" /incds=0 /nref=193 /ntot=248 /MaxReadThrough="0.81591" /MaxDrop="5.75977" /score="19.8797745" /energy="-8.6" /TU="NA" /idTUdmin="U1490" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1761512..1761531) /Source="Nicolas_upshift_promotors" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1761524) /Source="Nicolas_upshifts" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1761543..1761549) /Source="Nicolas_upshift_promotors" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1761578..1761597) /Source="Nicolas_upshift_promotors" /id="U1491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.971028971028971" /xcortree=1438 /SigmaFactorBS="gtattgttacaatcttagcgtaaaaaaattacagcgttttca caagtgacaAATGGTATATTATATAGTGCataatgccgtttttctgtgcagaattgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1761588) /Source="Nicolas_upshifts" /id="U1491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.971028971028971" /xcortree=1438 /SigmaFactorBS="gtattgttacaatcttagcgtaaaaaaattacagcgttttca caagtgacaAATGGTATATTATATAGTGCataatgccgtttttctgtgcagaattgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1761601..1761608 /Source="Nicolas_upshift_promotors" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1761622..1761641 /Source="Nicolas_upshift_promotors" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1761626 /Source="Nicolas_upshifts" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="upshifts" CDS 1761671..1763434 /gene="ggt" /locus_tag="BSU_18410" /old_locus_tag="BSU18410" /EC_number="2.3.2.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8763966, 23335395, 24279353, 26370226, 28120195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763966, 23335395, 24279353, 26370226, 28120195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane bound gamma-glutamyltranspeptidase" /protein_id="NP_389723.1" /db_xref="EnsemblGenomes-Gn:BSU18410" /db_xref="EnsemblGenomes-Tr:CAB13724" /db_xref="GOA:P54422" /db_xref="InterPro:IPR000101" /db_xref="InterPro:IPR029055" /db_xref="PDB:2V36" /db_xref="PDB:3A75" /db_xref="PDB:3WHQ" /db_xref="PDB:3WHR" /db_xref="PDB:3WHS" /db_xref="SubtiList:BG11838" /db_xref="UniProtKB/Swiss-Prot:P54422" /translation="MKRTWNVCLTALLSVLLVAGSVPFHAEAKKPPKSYDEYKQVDVG KDGMVATAHPLASEIGADVLKKGGNAIDAAVAIQFALNVTEPMMSGIGGGGFMMVYDG KTKDTTIIDSRERAPAGATPDMFLDENGKAIPFSERVTKGTAVGVPGTLKGLEEALDK WGTRSMKQLITPSIKLAEKGFPIDSVLAEAISDYQEKLSRTAAKDVFLPNGEPLKEGD TLIQKDLAKTFKLIRSKGTDAFYKGKFAKTLSDTVQDFGGSMTEKDLENYDITIDEPI WGDYQGYQIATTPPPSSGGIFLLQMLKILDHFNLSQYDVRSWEKYQLLAETMHLSYAD RASYAGDPEFVNVPLKGLLHPDYIKERQQLINLDQVNKKPKAGDPWKYQEGSANYKQV EQPKDKVEGQTTHFTVADRWGNVVSYTTTIEQLFGTGIMVPDYGVILNNELTDFDAIP GGANEVQPNKRPLSSMTPTILFKDDKPVLTVGSPGGATIISSVLQTILYHIEYGMELK AAVEEPRIYTNSMSSYRYEDGVPKDVLSKLNGMGHKFGTSPVDIGNVQSISIDHENGT FKGVADSSRNGAAIGINLKRK*" /label="ggt CDS" gene 1761671..1763434 /gene="ggt" /locus_tag="BSU_18410" /old_locus_tag="BSU18410" /label="ggt gene" downshifts 1763415 /Source="Nicolas_upshifts" /id="D1009" /incds=0 /nref=24 /ntot=49 /MaxReadThrough="1.41914" /MaxDrop="5.80171" /score="3.23845421" /energy="-10.4" /TU="NA" /idTUdmin="U1492" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1763535..1764392) /gene="ftsR" /locus_tag="BSU_18420" /old_locus_tag="BSU18420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17526699" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17526699; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family)" /protein_id="NP_389724.1" /db_xref="EnsemblGenomes-Gn:BSU18420" /db_xref="EnsemblGenomes-Tr:CAB13725" /db_xref="GOA:O34685" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13552" /db_xref="UniProtKB/Swiss-Prot:O34685" /translation="MESGDLKIFQAVAREGSITKAAQMLNYVQSNVTARVHNLEEDLN IRLFHRTNRGMKLTAAGENLLQYADQVLSLLDQAEKSTRMSRQPKGPLRIGSLETMAV THLPEHAASFLRRFPEVDLSVNTADTHHLIQQVLDHKVDGAFVYGPVEHAAVRQLHVS HDELVLISSREGTAEDMLQQPMLFFGAGCSHRDRVKRLLEEAGIHNQKIIEFGTLEAI IKGVSAGMGTALLPKSAVDGSEHRTNVWIHQLPPSYQDLEIVFIYRKDFFITSAFQTF LDEINEMKR*" /label="ftsR CDS" gene complement(1763535..1764392) /gene="ftsR" /locus_tag="BSU_18420" /old_locus_tag="BSU18420" /label="ftsR gene" promotor_-10 complement(1764438..1764457) /Source="Nicolas_upshift_promotors" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1764458) /Source="Nicolas_upshifts" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1764471..1764478) /Source="Nicolas_upshift_promotors" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1764520..1765509 /gene="yogA" /locus_tag="BSU_18430" /old_locus_tag="BSU18430" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 23873705; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389725.1" /db_xref="EnsemblGenomes-Gn:BSU18430" /db_xref="EnsemblGenomes-Tr:CAB13726" /db_xref="GOA:O35017" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13553" /db_xref="UniProtKB/Swiss-Prot:O35017" /translation="MKAVIHNGKAGLLGLSVQDVPSTKPGYGEVKVKLKSAGLNHRDL FLMKNKSEQDPHMILGSDGAGIIEEIGEGVKNVTVQTEVVIFPTLNWDLTENVPPVPE ILGGPSDGTLAEYVIIPSQNAIKKPAYLSWEEAGVLPLSALTAYRALFTKGQLKKGEH LLIPGIGSGVATYALFMAKAIGATVSVTSRSEEKRKKALKLGADYAFDSYSNWDEQLQ GKKIDVVLDSIGPALFSEYFRHVKPNGRIVSFGASSGDNLSFPVRSLFFPQVNVLGTS MGSGEEFQAMLAFIDKHKLRPVIDRIYPLEKACEAYKRMQEGRQFGNIGIVME*" /label="yogA CDS" gene 1764520..1765509 /gene="yogA" /locus_tag="BSU_18430" /old_locus_tag="BSU18430" /label="yogA gene" S_feature complement(1764576..1765534) /Source="Nicolas_S_feature" /locus_tag="new_2007582_2008540_c" /HighExp="T-4.40H, T-5.40H, Glu, GM 45, Glucon, GM-0.1, Gly, GM-0.2, UNK1, GM 90" /AntisenseName="yogA" /AntisenseCor="-0.49303153269799599" /AntisenseRegPval="-17.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S682" CDS complement(1765566..1767047) /gene="gltB" /locus_tag="BSU_18440" /old_locus_tag="BSU18440" /EC_number="1.4.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3011766, 10651638, 11029411, 27223617" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3011766, 10651638, 11029411, 27223617; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate synthase (small subunit, NADP-dependent)" /protein_id="NP_389726.2" /db_xref="EnsemblGenomes-Gn:BSU18440" /db_xref="EnsemblGenomes-Tr:CAB13727" /db_xref="GOA:O34399" /db_xref="InterPro:IPR006005" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR028261" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12594" /db_xref="UniProtKB/Swiss-Prot:O34399" /translation="MGKPTGFMEIKREKPAERDPLTRLKDWKEYSAPFSEEASKRQGA RCMDCGTPFCQIGADINGFTSGCPIYNLIPEWNDLVYRGRWKEALERLLKTNNFPEFT GRVCPAPCEGSCTLAISDPAVSIKNIERTIIDKGFENGWIQPRIPKKRTGKKVAIVGS GPAGLASADQLNQAGHSVTVFERADRAGGLLTYGIPNMKLEKGIVERRIKLLTQEGID FVTNTEIGVDITADELKEQFDAVILCTGAQKQRDLLIEGRDSKGVHYAMDYLTLATKS YLDSNFKDKQFIDAKGKDVIVIGGGDTGADCVATALRQKAKSVHQFGKHPKLPPARTN DNMWPEQPHVFTLEYAYEEAEAKFGRDPREYSIQTTKMVADKNGKLKELHTIQMEKVK NEHGKYEFRELPGTEKVWPAQLVFIAIGFEGTEQPLLKQFGVNSVNNKISAAYGDYQT NIDGVFAAGDARRGQSLIVWAINEGREVAREVDRYLMGSSVLP*" /label="gltB CDS" gene complement(1765566..1767047) /gene="gltB" /locus_tag="BSU_18440" /old_locus_tag="BSU18440" /label="gltB gene" downshifts complement(1765579) /Source="Nicolas_upshifts" /id="D1010" /incds=0 /nref=247 /ntot=279 /MaxReadThrough="3.292" /MaxDrop="7.52772" /score="10.4717228" /energy="-6.5" /TU="U1495" /idTUdmin="U1495" /TUdmin="-570" /isTUend="FALSE" /label="downshifts" CDS complement(1767064..1771626) /gene="gltA" /locus_tag="BSU_18450" /old_locus_tag="BSU18450" /EC_number="1.4.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:39113, 3011766, 6769440, 6774712, 7559359, 14570271, 17134717" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 39113, 3011766, 6769440, 6774712, 7559359, 14570271, 17134717; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate synthase (large subunit, NADP-dependent)" /protein_id="NP_389727.2" /db_xref="EnsemblGenomes-Gn:BSU18450" /db_xref="EnsemblGenomes-Tr:CAB13728" /db_xref="GOA:P39812" /db_xref="InterPro:IPR002489" /db_xref="InterPro:IPR002932" /db_xref="InterPro:IPR006982" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR036485" /db_xref="SubtiList:BG10811" /db_xref="UniProtKB/Swiss-Prot:P39812" /translation="MTYNQMPKAQGLYRPEFEHDACGIGLYAHLKGKQTHDIVKQGLK MLCQLDHRGGQGSDPDTGDGAGLLVQIPDAFFRKECKNINLPEKERYGVGMVFFSQKE DERKKIEKQINALIEQEGQVVLGWRTVPVNVGKIGTVAQKSCPFVRQVFIGASSDLKD NLSFERKLYVIRKQAENWGVTEGLDFYFASLSSQTIVYKGLLTPEQVDAFYSDLQDEA FVSAFALVHSRFSTNTFPTWERAHPNRYLVHNGEINTLRGNINWMRAREQQFVSESFG EDLNKILPILNADGSDSSILDNAFEFFVMAGRKPAHTAMMLIPEPWTENTHMSKEKRA FYEYHSSLMEPWDGPTAISFTDGKQIGAILDRNGLRPARYYVTKDDYIIFSSEVGVIE VEQENVLYKNRLEPGKMLLIDLEEGRIISDEEVKTQIATEYPYQKWLEEELVQVNPDP ESREEEQFSDLLTRQKAFGYTYEDIQKYLIPVIKEGKDPLGSMGNDAPLAVLSDRAQS LFNYFKQLFAQVTNPPIDAIREQLVTSTMTWLGAEGDLLHPSERNVRRIKLYTPVLSN EQFYALKTIVHPDLKSQKIDVLFSEDLERGLKDMFTQAEKAISQGVSLLILSDKKMNE RLTPIPPLLAVSALHQHLIRKGLRTKVSIIVESGEAREVHHFAALIGYGADAINPYLA YATYKQEIDEGRLDISYEEAVSKYGKSITEGVVKVMSKMGISTVQSYRGAQIFEAVGI SRDVIDRYFSGTASQLGGIDLQTIAEEAQRRHREAYQDDYSKTLEPGSDFQWRNGGEH HAFNPKTIHTLQWACRRNDYNLFKQYTKAADEERIGFLRNLFAFDGNRKPLKLEEVES AESIVKRFKTGAMSFGSLSKEAHEALAIAMNRLGGKSNSGEGGEDPKRFVPDENGDDR RSAIKQIASGRFGVKSHYLVNADELQIKMAQGAKPGEGGQLPGNKVYPWVADVRGSTP GVGLISPPPHHDIYSIEDLAQLIHDLKNANRDARISVKLVSKAGVGTIAAGVAKATAD VIVISGYDGGTGASPKTSIKHTGLPWELGLAEAHQTLMLNGLRDRVVLETDGKLMTGR DVVMAALLGAEEFGFATAPLVVLGCVMMRACHLDTCPVGVATQNPELRKKFMGDPDHI VNYMLFIAEEVREYMAALGFKTFDEMIGRTDVLHASERAKEHWKASQLDLSTLLYQPE GVRTFQSPQNHKIDQSLDITTILPAVQEAIESGKEADISIEINNTNRVAGTITGSEIS KRYGEEGLPEDTIKLHFTGSAGQSFGAFVPKGMTLYLDGDSNDYVGKGLSGGKIIVKS SEGFNSASDDNVIIGNVAFYGATSGEAYINGRAGERFAVRNSGVNVVVEGIGDHGCEY MTGGSVVVLGDVGKNFAAGMSGGIAYVLTEDVKAFKRKCNLEMILFESLEDEKEIQQI KAMLERHTAYTNSQKAEDLLDQWEDSVKKFVKVIPKNYKQMLASIEEQKAAGLSDEEA IMFAFEANTKPKQNTAASGQKQAVVQ*" /label="gltA CDS" gene complement(1767064..1771626) /gene="gltA" /locus_tag="BSU_18450" /old_locus_tag="BSU18450" /label="gltA gene" promotor_no_box 1770087..1770187 /Source="Nicolas_upshift_promotors" /id="U1494" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.001998001998002" /xcortree=23 /SigmaFactorBS="taaagtagttaaacagcgattgcgctcggtcagaaagtacag caagcggagcgtcattccccattgaaccaaggggatctttgccttctttaataacagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1770147 /Source="Nicolas_upshifts" /id="U1494" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.001998001998002" /xcortree=23 /SigmaFactorBS="taaagtagttaaacagcgattgcgctcggtcagaaagtacag caagcggagcgtcattccccattgaaccaaggggatctttgccttctttaataacagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1771627..1771698) /Source="Nicolas_S_feature" /locus_tag="new_2014633_2014704_c" /HighExp="SMM, T-5.40H, HiOs, MG 15, Glu, T-4.40H, MG 150, MG 60, UNK1, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S683" promotor_-10 complement(1771678..1771697) /Source="Nicolas_upshift_promotors" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1771695..1771702 /Source="Nicolas_upshift_promotors" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1771698) /Source="Nicolas_upshifts" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1771712..1771719) /Source="Nicolas_upshift_promotors" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1771714 /Source="Nicolas_upshifts" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1771717..1771736 /Source="Nicolas_upshift_promotors" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1771773..1772675 /gene="gltC" /locus_tag="BSU_18460" /old_locus_tag="BSU18460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2548995, 15150225, 17134717, 28294562" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2548995, 15150225, 17134717, 28294562; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family) (GltC-glutamate)" /protein_id="NP_389728.2" /db_xref="EnsemblGenomes-Gn:BSU18460" /db_xref="EnsemblGenomes-Tr:CAB13729" /db_xref="GOA:P20668" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10810" /db_xref="UniProtKB/Swiss-Prot:P20668" /translation="MELRQLRYFMEVAEREHVSEAADHLHVAQSAISRQIANLEEELN VTLFEREGRNIKLTPIGKEFLIHVKTAMKAIDYAKEQIDEYLDPHRGTVKIGFPTSLA SQLLPTVISAFKEEYPHVEFLLRQGSYKFLIEAVRNRDIDLALLGPVPTNFSDITGKI LFTEKIYALVPLNHPLAKQKTVHLIDLRNDQFVLFPEGFVLREMAIDTCKQAGFAPLV STEGEDLDAIKGLVSAGMGVTLLPESTFAETTPRFTVKIPIEFPQVKRTVGIIKPKNR ELAPSANDFYEFVIQFFSKLEQYQ*" /label="gltC CDS" gene 1771773..1772675 /gene="gltC" /locus_tag="BSU_18460" /old_locus_tag="BSU18460" /label="gltC gene" downshifts 1772655 /Source="Nicolas_upshifts" /id="D1011" /incds=0 /nref=104 /ntot=241 /MaxReadThrough="2.84467" /MaxDrop="3.98111" /score="22.3639229" /energy="-13.6" /TU="NA" /idTUdmin="U1496" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1772727..1773842) /gene="proJ" /locus_tag="BSU_18470" /old_locus_tag="BSU18470" /EC_number="2.7.2.11" /function="16.8: Protect" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:11418582, 15804359, 21784929, 28752945" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 15804359, 21784929, 28752945; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate 5-kinase" /protein_id="NP_389729.1" /db_xref="EnsemblGenomes-Gn:BSU18470" /db_xref="EnsemblGenomes-Tr:CAB13740" /db_xref="GOA:O07509" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR005715" /db_xref="InterPro:IPR011529" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019797" /db_xref="InterPro:IPR036393" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG12658" /db_xref="UniProtKB/Swiss-Prot:O07509" /translation="MTPDTSMKRVVVKIGSSSLTSLHGEISIRKLEALVDQVVKLKDA GYEVILVSSGAVAAGYRKLGFIQRPEKLPEKQASASIGQGLLMEAYSKLFLAHGYVAS QILITRSDFSDEYRYNNVRNTMNVLLERGIIPIINENDTVTVNRLKFGDNDTLAAKVA GLIDADMLVILSDIDGLYDGNPRTNPEAKKIQRVSEITPDIEACAGDTGSIVGTGGMR SKLDAFKIVMASGIKGFLGQADAGDILYHAVHEQAEGTYFEAEGTLPLNQKEQWIAFN SGPEGEMILSDDCSRKITNGQSSLYLDGVQKIKGKFKSGSVVRLMDSKGTEIGLGIVN YSSVQLQEPEKKKELTNRALIDQEAFVCHVDFSLPVN*" /label="proJ CDS" gene complement(1772727..1773842) /gene="proJ" /locus_tag="BSU_18470" /old_locus_tag="BSU18470" /label="proJ gene" CDS complement(1773839..1774732) /gene="proH" /locus_tag="BSU_18480" /old_locus_tag="BSU18480" /EC_number="1.5.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 21784929, 22139509, 25344233, 28752945" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 21784929, 22139509, 25344233, 28752945; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrroline-5-carboxylate reductase" /protein_id="NP_389730.2" /db_xref="EnsemblGenomes-Gn:BSU18480" /db_xref="EnsemblGenomes-Tr:CAB13741" /db_xref="GOA:P0CI77" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11049" /db_xref="UniProtKB/Swiss-Prot:P0CI77" /translation="MRTKKRTKEMLPIFDQKKVAFIGAGSMAEGMISGIVRANKIPKQ NICVTNRSNTERLTELELQYGIKGALPNQLCIEDMDVLILAMKPKDAENALSSLKSRI QPHQLILSVLAGITTSFIEQSLLNEQPVVRVMPNTSSMIGASATAIALGKYVSEDLKK LAEALLGCMGEVYTIQENQMDIFTGIAGSGPAYFYYLMEFIEKTGEEAGLDKQLSRSI GAQTLLGAAKMLMETGEHPEILRDNITSPNGTTAAGLQALKKSGGGEAISQAIKHAAK RSKEISEDIEKTAAPLSGVIK*" /label="proH CDS" gene complement(1773839..1774732) /gene="proH" /locus_tag="BSU_18480" /old_locus_tag="BSU18480" /label="proH gene" promotor_-10 complement(1774737..1774756) /Source="Nicolas_upshift_promotors" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1774745 /Source="Nicolas_upshifts" /id="D1012" /incds=0 /nref=1 /ntot=6 /MaxReadThrough="1.17009" /MaxDrop="3.27004" /score="-0.988973561" /energy="-13.3" /TU="NA" /idTUdmin="U1496" /TUdmin=2090 /isTUend="FALSE" /label="downshifts" upshifts complement(1774755) /Source="Nicolas_upshifts" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1774770..1774776) /Source="Nicolas_upshift_promotors" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1774785..1774803) /Source="Nicolas_upshift_promotors" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1774803) /Source="Nicolas_upshifts" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1774819..1774824) /Source="Nicolas_upshift_promotors" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1774880..1775248) /gene="rtp" /locus_tag="BSU_18490" /old_locus_tag="BSU18490" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11313334, 15657033, 16822523, 17376071, 17521668, 24946150" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11313334, 15657033, 16822523, 17376071, 17521668, 24946150; Product type f : factor" /codon_start=1 /transl_table=11 /product="replication terminator protein" /protein_id="NP_389731.1" /db_xref="EnsemblGenomes-Gn:BSU18490" /db_xref="EnsemblGenomes-Tr:CAB13742" /db_xref="GOA:P0CI76" /db_xref="InterPro:IPR003432" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1BM9" /db_xref="PDB:1F4K" /db_xref="PDB:1J0R" /db_xref="PDB:2DPD" /db_xref="PDB:2DPU" /db_xref="PDB:2DQR" /db_xref="PDB:2EFW" /db_xref="SubtiList:BG10738" /db_xref="UniProtKB/Swiss-Prot:P0CI76" /translation="MKEEKRSSTGFLVKQRAFLKLYMITMTEQERLYGLKLLEVLRSE FKEIGFKPNHTEVYRSLHELLDDGILKQIKVKKEGAKLQEVVLYQFKDYEAAKLYKKQ LKVELDRCKKLIEKALSDNF*" /label="rtp CDS" gene complement(1774880..1775248) /gene="rtp" /locus_tag="BSU_18490" /old_locus_tag="BSU18490" /label="rtp gene" promotor_-10 complement(1775283..1775301) /Source="Nicolas_upshift_promotors" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="promotor_-10" upshifts complement(1775306) /Source="Nicolas_upshifts" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="upshifts" S_feature complement(1775308..1775427) /Source="Nicolas_S_feature" /locus_tag="new_2018314_2018433_c" /HighExp="dia15, Etha, dia5, Diami, H2O2, LBGtran, LoTm, LBGexp, G180, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S684" promotor_-35 complement(1775313..1775321) /Source="Nicolas_upshift_promotors" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="promotor_-35" promotor_-10 complement(1775419..1775438) /Source="Nicolas_upshift_promotors" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1775427) /Source="Nicolas_upshifts" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1775429..1775525) /Source="Nicolas_S_feature" /locus_tag="new_2018435_2018531_c" /HighExp="Etha, dia15, LBGtran, LoTm, dia5, H2O2, LBGexp, M0t45, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S685" promotor_-35 complement(1775453..1775460) /Source="Nicolas_upshift_promotors" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1775548..1776264) /gene="yoxD" /locus_tag="BSU_18500" /old_locus_tag="BSU18500" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15317791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxido-reductase" /protein_id="NP_389732.1" /db_xref="EnsemblGenomes-Gn:BSU18500" /db_xref="EnsemblGenomes-Tr:CAB13743" /db_xref="GOA:P14802" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11048" /db_xref="UniProtKB/Swiss-Prot:P14802" /translation="MQSLQHKTALITGGGRGIGRATALALAKEGVNIGLIGRTSANVE KVAEEVKALGVKAAFAAADVKDADQVNQAVAQVKEQLGDIDILINNAGISKFGGFLDL SADEWENIIQVNLMGVYHVTRAVLPEMIERKAGDIINISSTAGQRGAAVTSAYSASKF AVLGLTESLMQEVRKHNIRVSALTPSTVASDMSIELNLTDGNPEKVMQPEDLAEYMVA QLKLDPRIFIKTAGLWSTNP*" /label="yoxD CDS" gene complement(1775548..1776264) /gene="yoxD" /locus_tag="BSU_18500" /old_locus_tag="BSU18500" /label="yoxD gene" downshifts complement(1775570) /Source="Nicolas_upshifts" /id="D1013" /incds=0 /nref=109 /ntot=217 /MaxReadThrough="4.9568" /MaxDrop="5.08605" /score="27.1231718" /energy="-7.5" /TU="U1501" /idTUdmin="U1500" /TUdmin="-594" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1776302..1776321) /Source="Nicolas_upshift_promotors" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1776311) /Source="Nicolas_upshifts" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1776337..1776340) /Source="Nicolas_upshift_promotors" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1776365..1776371 /Source="Nicolas_upshift_promotors" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1776385..1776403 /Source="Nicolas_upshift_promotors" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1776390 /Source="Nicolas_upshifts" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="upshifts" CDS 1776415..1776720 /gene="yoxC" /locus_tag="BSU_18510" /old_locus_tag="BSU18510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16513748, 17598888; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="transition-dependent and sulfur-related metabolism protein" /protein_id="NP_389733.1" /db_xref="EnsemblGenomes-Gn:BSU18510" /db_xref="EnsemblGenomes-Tr:CAB13744" /db_xref="InterPro:IPR009293" /db_xref="SubtiList:BG11047" /db_xref="UniProtKB/Swiss-Prot:P28670" /translation="MIIVYISLAVLAVSIIFLGVTVIQNKKKIDPALKELSSVTQAMQ KQIEGLKTETELLTQKQKKIQQDVQIKKYTLQQTAAEVKEVPQAVKEVWQAGHFNSR* " /label="yoxC CDS" gene 1776415..1776720 /gene="yoxC" /locus_tag="BSU_18510" /old_locus_tag="BSU18510" /label="yoxC gene" downshifts 1776704 /Source="Nicolas_upshifts" /id="D1014" /incds=0 /nref=6 /ntot=88 /MaxReadThrough="5.31272" /MaxDrop="3.8396" /score="-9.7711365" /energy="-17.8" /TU="U1502" /idTUdmin="U1503" /TUdmin="-1473" /isTUend="FALSE" /label="downshifts" CDS 1776791..1777561 /gene="yoxB" /locus_tag="BSU_18520" /old_locus_tag="BSU18520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717291, 17598888, 19703276" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389734.1" /db_xref="EnsemblGenomes-Gn:BSU18520" /db_xref="EnsemblGenomes-Tr:CAB13745" /db_xref="InterPro:IPR020530" /db_xref="InterPro:IPR036895" /db_xref="SubtiList:BG11046" /db_xref="UniProtKB/Swiss-Prot:P28671" /translation="MIINRSCLKEFAEKVHFLPSSLTKSDLLTDPFRLHQENELGIYY SPHNEFINRDASLVIAGITPGFSQMKTAYETAAESLLQGGTLEQMAVDTKIAAGFSGS MRHNLITMLDLCGLPQAFGIQSAAKLFGELRHMLHTTSVIKYPVFIQQKNYTGYKPAI THSPILSTYAFGHFPAELNHVTGPALLIPLGKAAETVCETLIRQHSLQNLICLNGFPH PSGANGHRLKQFSKNKEQLERQIRSFAALVDFAIEKRK*" /label="yoxB CDS" gene 1776791..1777561 /gene="yoxB" /locus_tag="BSU_18520" /old_locus_tag="BSU18520" /label="yoxB gene" promotor_-35 1777543..1777550 /Source="Nicolas_upshift_promotors" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1777562 /Source="Nicolas_upshifts" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1777565..1777584 /Source="Nicolas_upshift_promotors" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1777605..1778138 /gene="yoaA" /locus_tag="BSU_18530" /old_locus_tag="BSU18530" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513, 11717291, 17598888; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_389735.2" /db_xref="EnsemblGenomes-Gn:BSU18530" /db_xref="EnsemblGenomes-Tr:CAB13746" /db_xref="GOA:O34569" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13472" /db_xref="UniProtKB/Swiss-Prot:O34569" /translation="MFPILETDRLILRQITDQDAEAIFACFSNDEVTRYYGLENMESI EQAISMIQTFAALYQEKRGIRWGIERRDTKELIGTIGFHALAQKHRRAEIGYEIIPEH WRNGFASEVISKVVSYGFSALGLSRIGAVVFTDNEASNRLLLKMGFQKEGVLRQYMYQ NGTPYDTNVYSIVKPRE*" /label="yoaA CDS" gene 1777605..1778138 /gene="yoaA" /locus_tag="BSU_18530" /old_locus_tag="BSU18530" /label="yoaA gene" S_feature 1778139..1778224 /Source="Nicolas_S_feature" /locus_tag="new_2021145_2021230" /HighExp="Salt, Sw, B60, LoTm, B36, M9-stat, BC, Lbstat, HiTm, Etha" /AntisenseName="yoaB" /AntisenseCor="-0.17521117067018899" /AntisenseRegPval="-2.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S686" downshifts 1778181 /Source="Nicolas_upshifts" /id="D1015" /incds=0 /nref=6 /ntot=100 /MaxReadThrough="4.32682" /MaxDrop="3.67936" /score="-9.7711365" /energy="-17.8" /TU="U1502" /idTUdmin="U1503" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(1778217..1779461) /gene="yoaB" /locus_tag="BSU_18540" /old_locus_tag="BSU18540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12193636, 15849754, 16513748, 16850406, 28546427; Product type t : transporter" /codon_start=1 /transl_table=11 /product="negatively charged metabolite transporter" /protein_id="NP_389736.1" /db_xref="EnsemblGenomes-Gn:BSU18540" /db_xref="EnsemblGenomes-Tr:CAB13747" /db_xref="GOA:O34864" /db_xref="InterPro:IPR004748" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13473" /db_xref="UniProtKB/Swiss-Prot:O34864" /translation="MLDKIGIPKRLAWGFLGVVLFMMGDGLEQGWLSPFLIENGLTVQ QSASIFSIYGIALAIASWFSGVCLEAFGAKRTMFMGLLFYVIGTAAFIVFGFEQLNLP VMYVTYFVKGLGYPLFAYSFLTWVIYRTPQSKLSTAVGWFWIAYCLGMFVFGAWYSSY AIKAFGYLNTLWSSIFWVCLGAFFALFINKDRFEKKKRKRSETAEELLKGVTILFTNP RVLTGGIIRIINSIGTYGFPVFLPMHMAQHGISTNVWLQIWGTIFLGNIVFNLIFGIV GDKFGWKNTVIWFGGVGCGIFTVLLYYAPVFSGGSLAVVSVIGFIWGGLLAGYVPIGA IVPTVAGKDKGAAMSVLNLAAGLSAFVGPALAWLFIGLVGAQGVVWIFAALYLASAVL TKCIHIPEEKAVKEETSPQYAS*" /label="yoaB CDS" gene complement(1778217..1779461) /gene="yoaB" /locus_tag="BSU_18540" /old_locus_tag="BSU18540" /label="yoaB gene" S_feature 1778226..1778965 /Source="Nicolas_S_feature" /locus_tag="new_2021232_2021971" /HighExp="LoTm, Salt, Sw, S6, Etha, M9-stat, LPhT, B60, T2.0H, T2.30H" /AntisenseName="yoaB" /AntisenseCor="-0.18536963552729299" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S687" downshifts complement(1778231) /Source="Nicolas_upshifts" /id="D1016" /incds=0 /nref=32 /ntot=113 /MaxReadThrough="2.59019" /MaxDrop="4.97477" /score="29.0246554" /energy="-12.5" /TU="NA" /idTUdmin="U1504" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1779462..1779554) /Source="Nicolas_S_feature" /locus_tag="new_2022468_2022560_c" /HighExp="MG 10, MG 5, BMM, MG t5, MG 15, GM 25, HiTm, UNK1, GM 15, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S688" CDS complement(1779555..1781018) /gene="yoaC" /locus_tag="BSU_18550" /old_locus_tag="BSU18550" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10094622, 12193636, 16850406, 18039762, 21749987, 27795321, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroxylated metabolite kinase" /protein_id="NP_389737.1" /db_xref="EnsemblGenomes-Gn:BSU18550" /db_xref="EnsemblGenomes-Tr:CAB13748" /db_xref="GOA:O34861" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG13474" /db_xref="UniProtKB/Swiss-Prot:O34861" /translation="MKKQKGYLVFDIGTGNARVAVVSVTGSVLTVEREDIEYSTETLY PDSRYFSPQVLWKQVMNLAKRALSRSCDIDIIGLTSTSQRQGIVLIDQNGNPFLGLPN IDNRGREWEAGIPDWEEIYSSTGRLPTALFSALKLYGLKQRQPSLWEKTASFTSISDW VTYQLSGILTYEPSQATETLLFDVKQNTWSEEMCDIFGFSPSILPPLVRAGTAIGTIA NEYASELGLSINAKVIAGGGDTQLAVKSTGAGLEDIVIVSGTTTPITKITEDHGDTKH KAWLNCHTDQGHWLVETNPGITGLNYQKLKQIFYPNETYEVMEEEISALAKEDHACVA ALGSYLSAEKNALTRGGFLFDAPLSAHLKRAHFVRAALEEIAFSIKWNFDILTEVTPF ERDYVWVCGGGFQSKALTQYIADLLQKKVYVQEGYHQASVVGAAVICNETFQLTEEMS ANVRVIEPKDCQIELALYEEWKQTQRFFSGSESKVLI*" /label="yoaC CDS" gene complement(1779555..1781018) /gene="yoaC" /locus_tag="BSU_18550" /old_locus_tag="BSU18550" /label="yoaC gene" CDS complement(1781036..1782070) /gene="yoaD" /locus_tag="BSU_18560" /old_locus_tag="BSU18560" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10094622, 11390694, 12193636, 17012385, 18039762, 21749987, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2-hydroxyacid dehydrogenase" /protein_id="NP_389738.1" /db_xref="EnsemblGenomes-Gn:BSU18560" /db_xref="EnsemblGenomes-Tr:CAB13749" /db_xref="GOA:O34815" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13475" /db_xref="UniProtKB/Swiss-Prot:O34815" /translation="MKNTMKRMFCSMTVLVTAPYNEEGRKELENLFGSVAYQSWKEQG RAYREDELIQLLKATNATGLITELDQVTDSVFASVPELSFVGVCRGMPSNVDVAAASK RGIPVFYTPGRNAQAVAEMFIGNVISFLRHTSASNQWLKDGEWDSDYLQAYVKFKGNE LTGKTVGMIGFGAVGQRIAKLLTAFDCKIKYYDPYIQDDHPLYEKASLKTVFSDSDIV SVHLPRTEETLGLIDRQYFDLMKESAIFVNTSRAVVVNREDLLFVLKEHKISGAILDV FYHEPPEESDYELISLPNVLATPHLAGATFEVEDHHVTILNKALKKWKGEKTLNIQTM YNKDALKTGG*" /label="yoaD CDS" gene complement(1781036..1782070) /gene="yoaD" /locus_tag="BSU_18560" /old_locus_tag="BSU18560" /label="yoaD gene" S_feature complement(1782082..1782153) /Source="Nicolas_S_feature" /locus_tag="new_2025088_2025159_c" /HighExp="MG t5, MG 5, MG 10, BMM, GM 25, MG 15, Heat, GM 15, MG-0.2, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S689" downshifts complement(1782125) /Source="Nicolas_upshifts" /id="D1017" /incds=0 /nref=1 /ntot=24 /MaxReadThrough="7.78218" /MaxDrop="4.81701" /score="26.3160061" /energy="-11.4" /TU="U1504" /idTUdmin="U1507" /TUdmin=2727 /isTUend="FALSE" /label="downshifts" misc_RNA complement(1782154..1782245) /gene="mswF" /locus_tag="BSU_misc_RNA_31" /product="AdoMet riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswF RNA" gene complement(1782154..1782245) /gene="mswF" /locus_tag="BSU_misc_RNA_31" /label="mswF gene" promotor_-10 complement(1782273..1782292) /Source="Nicolas_upshift_promotors" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1782285) /Source="Nicolas_upshifts" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1782307..1782314) /Source="Nicolas_upshift_promotors" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1782327..1782334 /Source="Nicolas_upshift_promotors" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1782348..1782367 /Source="Nicolas_upshift_promotors" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1782352 /Source="Nicolas_upshifts" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="upshifts" CDS 1782394..1784436 /gene="yoaE" /locus_tag="BSU_18570" /old_locus_tag="BSU18570" /EC_number="1.-.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2170332, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin cofactor oxido-reductase" /protein_id="NP_389739.2" /db_xref="EnsemblGenomes-Gn:BSU18570" /db_xref="EnsemblGenomes-Tr:CAB13750" /db_xref="GOA:C0SP82" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG13476" /db_xref="UniProtKB/Swiss-Prot:C0SP82" /translation="MRSFATQQNGIFKSVCSLDCPDQCGLLIHKKDGKIVKVQGDPDH PVTAGNICNKVRNMTERIYDEKRLTTPLKRTGAKGQAIFEPISWKEAIDTITSRWKQL IDEEGAESILPYSFYGNMGKLTAEGMDRRFFYRMGSSQLERTICSKAGSEGYKYTMGI SAGIDPEETVHTKLFIFWGINAVSTNMHQITIAQKARKKGAKIVVIDVHKNQTGRLAD WFIPIKPGTDSALALGIMHILFKENLHDEAFLSEYTVGYEELREHVKQYDPEKVSTIT GVSTEDIYRLAKMYGETSPSFIRIGNGPQHHDNGGMIVRTIACLPAITGQWLHTGGGA IKHNSGILEYNTNALQRPDLLKGRTPRSFNMNQLGRVLLETDPPIRSLFIYGTNPAVV APEANKVRQGLLREDLFTVVHDLFLTETAAYADIVLPATSAFENTDFYTSYWHHYIQL QQPVIERYGESKSNTEVFRLLAEAMGFTDQELKDSDEVLIRQALDHPDNPHLAEIDYD SLTKHSFMKAKREKPLFPGELPTPSGKIELYSEKMKQDGFPALPTYTPLVTDNEHPFM YVPGPNHNFLNSTFSNNEKHIKLEKTPKLFINTKDAEKHGIVDGAPVRIWNSRGECEL TAAVGEQVLPGVVVSQGLWADEQGKKQLVNALTPDRLSDMGGGATFFSGRVQIEKV*" /label="yoaE CDS" gene 1782394..1784436 /gene="yoaE" /locus_tag="BSU_18570" /old_locus_tag="BSU18570" /label="yoaE gene" promotor_-35 1784444..1784453 /Source="Nicolas_upshift_promotors" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1784466..1784481 /Source="Nicolas_upshift_promotors" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1784469 /Source="Nicolas_upshifts" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="upshifts" CDS 1784503..1784796 /gene="yoaF" /locus_tag="BSU_18580" /old_locus_tag="BSU18580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23155385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389740.1" /db_xref="EnsemblGenomes-Gn:BSU18580" /db_xref="EnsemblGenomes-Tr:CAB13751" /db_xref="SubtiList:BG13477" /db_xref="UniProtKB/Swiss-Prot:O31829" /translation="MDVFLGIGIALAGYFIGEGLKQRNQTKGNEQNDIFLIKERDIYF YIGLFLGITTTEAKQLAGDMADLPYIEINGKKYVQKHMLKDWTFTLVEKHQGE*" /label="yoaF CDS" gene 1784503..1784796 /gene="yoaF" /locus_tag="BSU_18580" /old_locus_tag="BSU18580" /label="yoaF gene" downshifts 1784776 /Source="Nicolas_upshifts" /id="D1018" /incds=0 /nref=97 /ntot=243 /MaxReadThrough="3.40762" /MaxDrop="4.1662" /score="-6.27063114" /energy="-3.9" /TU="U1506" /idTUdmin="U1505" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1784821..1785168) /Source="Nicolas_S_feature" /locus_tag="new_2027827_2028174_c" /HighExp="T0.30H, S0, T1.0H, aero, Etha, S8, SMMPr, T-0.40H, ferm, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S690" downshifts complement(1784852) /Source="Nicolas_upshifts" /id="D1019" /incds=0 /nref=43 /ntot=202 /MaxReadThrough="2.3171" /MaxDrop="4.25059" /score="-6.12586993" /energy="-17.4" /TU="NA" /idTUdmin="U1507" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1785169..1785573) /gene="yoaG" /locus_tag="BSU_18590" /old_locus_tag="BSU18590" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871, 15849754, 16850406, 20011599, 23155385; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative phage-related membrane protein" /protein_id="NP_389741.1" /db_xref="EnsemblGenomes-Gn:BSU18590" /db_xref="EnsemblGenomes-Tr:CAB13752" /db_xref="GOA:O31830" /db_xref="InterPro:IPR031374" /db_xref="SubtiList:BG13478" /db_xref="UniProtKB/Swiss-Prot:O31830" /translation="MKKIASYYLMTLGLSSLTFGLLLGFYSFVMYGDMIIALFTAAIA LLYGFVVYGLFAVPLQMKLQKKARTFNVMYLLIYSVVAFIAAFLFFVINEPASIAWTL QSYFYYMLSIAAAVIYWLWDSLILYKRTASGV*" /label="yoaG CDS" gene complement(1785169..1785573) /gene="yoaG" /locus_tag="BSU_18590" /old_locus_tag="BSU18590" /label="yoaG gene" S_feature complement(1785574..1785669) /Source="Nicolas_S_feature" /locus_tag="new_2028580_2028675_c" /HighExp="T0.30H, T1.0H, T0.0H, T-0.40H, S0, T-1.10H, T-1.40H, SMMPr, Salt, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S691" promotor_-10 complement(1785659..1785674) /Source="Nicolas_upshift_promotors" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1785659..1785778) /locus_tag="BSU_18595" /old_locus_tag="BSU18595" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513962.1" /translation="MHFFHSRFGQSGEAFSASVLSNKRTSFLKPFISALRIAR*" /label="hypothetical protein CDS" gene complement(1785659..1785778) /locus_tag="BSU_18595" /old_locus_tag="BSU18595" /label="gene" upshifts complement(1785669) /Source="Nicolas_upshifts" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1785687..1785696) /Source="Nicolas_upshift_promotors" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1785774..1785780 /Source="Nicolas_upshift_promotors" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1785794..1785805 /Source="Nicolas_upshift_promotors" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1785805..1786013 /Source="Nicolas_S_feature" /locus_tag="new_2028811_2029019" /HighExp="S5, S8, S7, S6, S4, ferm, BT, nit, T5.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99998799999999999" /TUshortSig="SigGF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S692" upshifts 1785805 /Source="Nicolas_upshifts" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="upshifts" CDS 1785848..1785970 /locus_tag="BSU_18596" /old_locus_tag="BSU18596" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513963.1" /db_xref="EnsemblGenomes-Gn:BSU18596" /db_xref="EnsemblGenomes-Tr:CCQ48597" /db_xref="UniProtKB/TrEMBL:L8E9J0" /translation="MSKKGIQNSSIEQIRNDHETETAFKADDPKKHGSDPKRTK*" /label="conserved hypothetical protein CDS" gene 1785848..1785970 /locus_tag="BSU_18596" /old_locus_tag="BSU18596" /label="gene" CDS 1786014..1786307 /gene="yozQ" /locus_tag="BSU_18600" /old_locus_tag="BSU18600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="YP_054581.1" /db_xref="EnsemblGenomes-Gn:BSU18600" /db_xref="EnsemblGenomes-Tr:CAE01456" /db_xref="InterPro:IPR025100" /db_xref="SubtiList:BG14189" /db_xref="UniProtKB/Swiss-Prot:Q7WY68" /translation="MTQKNGADRPDDYKRFSSLDKEYDFQQSIRSNTETESVNTETQT HNKENKNDTTDVAGKYFEPSDYKGSTQLEKGLAETHEQVSDDYFEGTIDQNLD*" /label="yozQ CDS" gene 1786014..1786307 /gene="yozQ" /locus_tag="BSU_18600" /old_locus_tag="BSU18600" /label="yozQ gene" S_feature 1786308..1786401 /Source="Nicolas_S_feature" /locus_tag="new_2029314_2029407" /HighExp="S5, S8, S6, S7, S4, BT, ferm, nit, T5.0H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S693" downshifts 1786358 /Source="Nicolas_upshifts" /id="D1020" /incds=0 /nref=14 /ntot=74 /MaxReadThrough="3.32407" /MaxDrop="3.87581" /score="-6.27063114" /energy="-3.9" /TU="U1508" /idTUdmin="U1506" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1786423..1788108) /gene="yoaH" /locus_tag="BSU_18610" /old_locus_tag="BSU18610" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535, 27899502; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative methyl-accepting chemotaxis protein" /protein_id="NP_389742.2" /db_xref="EnsemblGenomes-Gn:BSU18610" /db_xref="EnsemblGenomes-Tr:CAB13753" /db_xref="GOA:C0SP89" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR007891" /db_xref="SubtiList:BG13479" /db_xref="UniProtKB/Swiss-Prot:C0SP89" /translation="MKVKTKLLGIISILVVSIIGIGGSSVFMISSTVKKNEELKDKME FQKEIKHIQYELTGLSNDERGFLITRDKEYDEGMKGKADDVLKSLDRVNDLIDEEKYQ SNIEDIKTSFTQYRALNQQVVTAYSSNPKKAETIHFGEERTIRKEGVAPAVNKLSDRL DQEVEDLKDEIQGNGKMSQSLIIIVTGISVILGIVLSIMLLKSIMVPLRSINKQLEEI AHGEADLTKKVIVKNKDEFGQLAQSFNSFTHSLTQIVKQISSSSEQVAASSEELSASA EESKSTSEHISRAMQMAADSNVKQSSMTEKSAESITELLDSISSVASNTGNIADLSSS MRDKAEIGSKSVNKMLDQMKFIDKSVDSAGNGLQTLVASTAEISDISSLITTISEQTN LLALNAAIEAARAGEQGKGFAVVAEEVRKLADETNKSANHIQSVVATIQNESIETVNN IKVVQENVSSGIVLSQETTGNFNEILNLVEQVTSQIQEVAAATQQLTSGVEVIQHTVH TLAAGTKETSANTEAVANSSQEQLHSMGEISYAAESLSQLAEELQTVINRFKY*" /label="yoaH CDS" gene complement(1786423..1788108) /gene="yoaH" /locus_tag="BSU_18610" /old_locus_tag="BSU18610" /label="yoaH gene" downshifts complement(1786435) /Source="Nicolas_upshifts" /id="D1021" /incds=0 /nref=68 /ntot=193 /MaxReadThrough="2.22411" /MaxDrop="4.20676" /score="-6.12586993" /energy="-17.4" /TU="NA" /idTUdmin="U1509" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" S_feature complement(1788109..1788196) /Source="Nicolas_S_feature" /locus_tag="new_2031115_2031202_c" /HighExp="Cold, C30, LBGstat, GM 90, GM 15, GM 45, GM 25, GM 60, GM 10, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.115923" /TUshortSig="SigD" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S694" promotor_-10 complement(1788188..1788206) /Source="Nicolas_upshift_promotors" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1788196) /Source="Nicolas_upshifts" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1788220..1788227) /Source="Nicolas_upshift_promotors" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1788365..1788374 /Source="Nicolas_upshift_promotors" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1788384 /Source="Nicolas_upshifts" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1788387..1788406 /Source="Nicolas_upshift_promotors" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1788433..1789884 /gene="yoaI" /locus_tag="BSU_18620" /old_locus_tag="BSU18620" /EC_number="1.14.14.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 4-hydroxyphenylacetate-3-hydroxylase" /protein_id="NP_389743.2" /db_xref="EnsemblGenomes-Gn:BSU18620" /db_xref="EnsemblGenomes-Tr:CAB13754" /db_xref="GOA:C0SPC0" /db_xref="InterPro:IPR004925" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR012687" /db_xref="InterPro:IPR024674" /db_xref="InterPro:IPR024719" /db_xref="InterPro:IPR036250" /db_xref="SubtiList:BG13480" /db_xref="UniProtKB/Swiss-Prot:C0SPC0" /translation="MGIINGKEFIDRLNKLENEIWYDGEKIKGNISEHPAFKGIIKTK SSLYELQTKDELIHEMTYCLPGDHNRIGLSYLQPKTKNDLKKRRTMIEHWARHTHGMM GRSPDYMNTVMMSFASSAELLKDKENCFPEHILDMYEQAAKHDLSFTHTFITPQVNRS QSYFGLSEKPISAKVIDRTEKGLMIHGARLLATQGGLTDEILVFSAPKFFFETDEAYA FSIPSNTKGVKFITRESFVLSDSSFNHPLSSRYEEMDSIVVFDHVLVPWNRVFFYDNV EAAKDFMTKSSFHAFTFHQVVIRQMIKIEFLLGVAQLLVDTINVSEYQHIQEKLSEII VGLETIKALIDKSENDAQLDEFGYMRPCLIPLQVISTIIPKLYPRFTEIIQLIGASGM VTLPTENAFDSEIREDLDQYLQATNTNAEERVKIFRLAWDLTMSSFGTRQTHYERYFF GDPIRISSRLYTSYPKQEQLNMIKTFLHADTEH*" /label="yoaI CDS" gene 1788433..1789884 /gene="yoaI" /locus_tag="BSU_18620" /old_locus_tag="BSU18620" /label="yoaI gene" downshifts 1789860 /Source="Nicolas_upshifts" /id="D1022" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="2.84304" /MaxDrop="2.93575" /score="2.7297367" /energy="-12" /TU="U1510" /idTUdmin="U1510" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1789921..1790619) /gene="exlX" /locus_tag="BSU_18630" /old_locus_tag="BSU18630" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12354229, 18971341, 26751268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 18971341, 26751268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular endoglucanase precursor (expansin)" /protein_id="NP_389744.1" /db_xref="EnsemblGenomes-Gn:BSU18630" /db_xref="EnsemblGenomes-Tr:CAB13755" /db_xref="GOA:O34918" /db_xref="InterPro:IPR009009" /db_xref="InterPro:IPR036749" /db_xref="InterPro:IPR036908" /db_xref="PDB:2BH0" /db_xref="PDB:3D30" /db_xref="PDB:4FER" /db_xref="PDB:4FFT" /db_xref="PDB:4FG2" /db_xref="PDB:4FG4" /db_xref="SubtiList:BG13481" /db_xref="UniProtKB/Swiss-Prot:O34918" /translation="MKKIMSAFVGMVLLTIFCFSPQASAAYDDLHEGYATYTGSGYSG GAFLLDPIPSDMEITAINPADLNYGGVKAALAGSYLEVEGPKGKTTVYVTDLYPEGAR GALDLSPNAFRKIGNMKDGKINIKWRVVKAPITGNFTYRIKEGSSRWWAAIQVRNHKY PVMKMEYEKDGKWINMEKMDYNHFVSTNLGTGSLKVRMTDIRGKVVKDTIPKLPESGT SKAYTVPGHVQFPE*" /label="exlX CDS" gene complement(1789921..1790619) /gene="exlX" /locus_tag="BSU_18630" /old_locus_tag="BSU18630" /label="exlX gene" downshifts complement(1789936) /Source="Nicolas_upshifts" /id="D1023" /incds=0 /nref=6 /ntot=95 /MaxReadThrough="0.66874" /MaxDrop="3.60414" /score="1.1918692" /energy="-7.7" /TU="NA" /idTUdmin="U1511" /TUdmin=132 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1790654..1790673) /Source="Nicolas_upshift_promotors" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1790673) /Source="Nicolas_upshifts" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1790675..1790888) /Source="Nicolas_S_feature" /locus_tag="new_2033681_2033894_c" /HighExp="G135, H2O2, G150, G180, LBGstat, dia15, LBGtran, Paraq, LBGexp, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S695" promotor_-35 complement(1790687..1790694) /Source="Nicolas_upshift_promotors" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1790889..1791566) /gene="yoaK" /locus_tag="BSU_18640" /old_locus_tag="BSU18640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_389745.1" /db_xref="EnsemblGenomes-Gn:BSU18640" /db_xref="EnsemblGenomes-Tr:CAB13756" /db_xref="GOA:O34343" /db_xref="InterPro:IPR010699" /db_xref="SubtiList:BG13482" /db_xref="UniProtKB/Swiss-Prot:O34343" /translation="MTAAAYRNTLLSLLCLTAGIVDVIGYLSLGHVFTANMTGNIVLL GLAIGKSIQVTVFNSLTALIGFICGVIIATLMVGKAENTLWPSAVTKALALEAFILFV FACLSFYRAFVPVHILIILMSISMGIQTTAAKKLGIAGISSTVLTGTLASLLEDISGR LFFKKQKKTFLRDTVLRALAIILYCVGAIIVALAEPDFYHFIIWVPIVLIFGIMMTAK LKLSGEK*" /label="yoaK CDS" gene complement(1790889..1791566) /gene="yoaK" /locus_tag="BSU_18640" /old_locus_tag="BSU18640" /label="yoaK gene" S_feature complement(1791567..1794056) /Source="Nicolas_S_feature" /locus_tag="new_2034573_2037062_c" /HighExp="LBGstat, G135, H2O2, G180, LBGtran, G150, dia15, Paraq, S0, Diami" /AntisenseName="pelB" /AntisenseCor="0.19898265589133701" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S696" CDS 1791739..1792776 /gene="pelB" /locus_tag="BSU_18650" /old_locus_tag="BSU18650" /EC_number="4.2.2.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1731776, 2018526, 2185758, 7764549, 22695924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-pectin lyase" /protein_id="NP_389746.1" /db_xref="EnsemblGenomes-Gn:BSU18650" /db_xref="EnsemblGenomes-Tr:CAB13757" /db_xref="GOA:O34819" /db_xref="InterPro:IPR002022" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG12643" /db_xref="UniProtKB/Swiss-Prot:O34819" /translation="MKRLCLWFTVFSLFLVLLPGKALGAVDFPNTSTNGLLGFAGNAK NEKGISKTGTTGGKNGQIVYIQSVNDLKTHLGGSTPKILVLQNDLSASAKTTVTIGSN KTLVGSYAKKTLKNIYLTTSSAFGNVIFQNLTFEHSPQINGNNDIQLYLDSGMNYWID HVTFSGHSYNASGSDLDKLVYIGKSADYITISNSKFANHKYGLILGYPDDSQHQYDGY PHMTIANNYFENLYVRGPGLMRYGYFHVKNNYSNNFNQAITIATKAKIYSEYNYFGKG SEKGGILDDKGTGYFKDIGSYPSLNKQTSPLTSWNPGSNYSYRVQTPEYTKEFVTKYA GSQSTTLVFGY*" /label="pelB CDS" gene 1791739..1792776 /gene="pelB" /locus_tag="BSU_18650" /old_locus_tag="BSU18650" /label="pelB gene" promotor_-35 1792973..1792979 /Source="Nicolas_upshift_promotors" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1792994..1793005 /Source="Nicolas_upshift_promotors" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1793006 /Source="Nicolas_upshifts" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="upshifts" CDS 1793033..1793716 /gene="yoaM" /locus_tag="BSU_18660" /old_locus_tag="BSU18660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23945014, 26070154; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative SOS response associated protein; defective prophage 6" /protein_id="NP_389747.1" /db_xref="EnsemblGenomes-Gn:BSU18660" /db_xref="EnsemblGenomes-Tr:CAB13758" /db_xref="GOA:O34906" /db_xref="InterPro:IPR003738" /db_xref="InterPro:IPR036590" /db_xref="SubtiList:BG13483" /db_xref="UniProtKB/Swiss-Prot:O34906" /translation="MCGRFTLYSAFDDIIDQFDIDQFFPKGEYQPSYNVAPSQNILAI INDGSNNRLGKLRWGLIPPWAKDEKIGYKMINARAETITEKPAFRRPLVSKRCIIPAD SFYEWKRLDSKTKIPMRIKLKSSALFAFAGLYEKWSTHQGYPLYTCTIITTEPNEFMK DIHDRMPVILAHDHEKEWLNPKNTSPDYLQSLLLPYDADDMEAYQVSSLVNSPKNNSA ELLDAENHM*" /label="yoaM CDS" gene 1793033..1793716 /gene="yoaM" /locus_tag="BSU_18660" /old_locus_tag="BSU18660" /label="yoaM gene" CDS complement(1794057..1794362) /gene="yozS" /locus_tag="BSU_18669" /old_locus_tag="BSU18669" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative permease, phage-related; defective prophage 6" /protein_id="YP_003097734.1" /db_xref="EnsemblGenomes-Gn:BSU18669" /db_xref="EnsemblGenomes-Tr:CAX52628" /db_xref="GOA:C0H420" /db_xref="UniProtKB/Swiss-Prot:C0H420" /translation="MKALIFLSSLTAIGSSILGRWLGMLDDSYAVGDAWFIGVLAGLI SLLILIDSQTMTKNYIVSLSTILGILGVGFIYFPAAFINILLSITLDKQKKEDLHVR* " /label="yozS CDS" gene complement(1794057..1794362) /gene="yozS" /locus_tag="BSU_18669" /old_locus_tag="BSU18669" /label="yozS gene" S_feature complement(1794363..1794464) /Source="Nicolas_S_feature" /locus_tag="new_2037369_2037470_c" /HighExp="HiTm, LBGstat, LBGtran, T1.30H, T1.0H, T0.30H, M9-stat, Lbstat, M0t90, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S697" promotor_-10 complement(1794443..1794462) /Source="Nicolas_upshift_promotors" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1794464) /Source="Nicolas_upshifts" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1794477..1794484) /Source="Nicolas_upshift_promotors" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1794492..1794594) /Source="Nicolas_S_feature" /locus_tag="new_2037498_2037600_c" /HighExp="S8, S6, S7, S5, BT, G/S, Pyr, B36, nit, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S698" downshifts complement(1794534) /Source="Nicolas_upshifts" /id="D1024" /incds=0 /nref=9 /ntot=21 /MaxReadThrough="1.67639" /MaxDrop="3.95763" /score="-5.39979801" /energy="-8.3" /TU="NA" /idTUdmin="U1514" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1794595..1795773) /gene="oxdD" /locus_tag="BSU_18670" /old_locus_tag="BSU18670" /EC_number="4.1.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11546787, 14697267, 14973022, 15628860, 25526893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11546787, 14697267, 14973022, 15628860, 25526893; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxalate decarboxylase (Mn2+-dependent); spore constituent" /protein_id="NP_389748.1" /db_xref="EnsemblGenomes-Gn:BSU18670" /db_xref="EnsemblGenomes-Tr:CAB13759" /db_xref="GOA:O34767" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR017774" /db_xref="SubtiList:BG13484" /db_xref="UniProtKB/Swiss-Prot:O34767" /translation="MLLEQQPINHEDRNVPQPIRSDGAGAIDTGPRNIIRDIQNPNIF VPPVTDEGMIPNLRFSFSDAPMKLDHGGWSREITVRQLPISTAIAGVNMSLTAGGVRE LHWHKQAEWAYMLLGRARITAVDQDGRNFIADVGPGDLWYFPAGIPHSIQGLEHCEFL LVFDDGNFSEFSTLTISDWLAHTPKDVLSANFGVPENAFNSLPSEQVYIYQGNVPGSV ASEDIQSPYGKVPMTFKHELLNQPPIQMPGGSVRIVDSSNFPISKTIAAALVQIEPGA MRELHWHPNSDEWQYYLTGQGRMTVFIGNGTARTFDYRAGDVGYVPSNAGHYIQNTGT ETLWFLEMFKSNRYADVSLNQWMALTPKELVQSNLNAGSVMLDSLRKKKVPVVKYPGT *" /label="oxdD CDS" gene complement(1794595..1795773) /gene="oxdD" /locus_tag="BSU_18670" /old_locus_tag="BSU18670" /label="oxdD gene" promotor_-10 complement(1795799..1795818) /Source="Nicolas_upshift_promotors" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1795818) /Source="Nicolas_upshifts" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1795832..1795841) /Source="Nicolas_upshift_promotors" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1795896..1796384) /gene="yoaO" /locus_tag="BSU_18680" /old_locus_tag="BSU18680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389749.1" /db_xref="EnsemblGenomes-Gn:BSU18680" /db_xref="EnsemblGenomes-Tr:CAB13760" /db_xref="InterPro:IPR032545" /db_xref="SubtiList:BG13485" /db_xref="UniProtKB/Swiss-Prot:O34985" /translation="MRKKNNIKKWLLIIAGFLIICIITLFVMVSGNKVKYEGSGKSGL WMSNLEKSDKTSIGPNYFLNLYWQGSKKEEKWTVVERITLYVDGEKYQDDNVDEYDLS EYTGDEMPGGGRMEDHISTFDYMPEDEVIGHDVLVKVEWRTGQKKQTEAIKLHKKPWY KK*" /label="yoaO CDS" gene complement(1795896..1796384) /gene="yoaO" /locus_tag="BSU_18680" /old_locus_tag="BSU18680" /label="yoaO gene" downshifts complement(1795921) /Source="Nicolas_upshifts" /id="D1025" /incds=0 /nref=32 /ntot=201 /MaxReadThrough="0.50319" /MaxDrop="3.84714" /score="18.561323" /energy="-9.2" /TU="NA" /idTUdmin="U1514" /TUdmin="-1387" /isTUend="FALSE" /label="downshifts" CDS complement(1796409..1796564) /locus_tag="BSU_18689" /old_locus_tag="BSU18689" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513964.1" /translation="MKQKMHLRAVIRFNLVFRKHFNLSQKFRQSSVRSLALSYFLFGN ILIVFSY*" /label="hypothetical protein CDS" gene complement(1796409..1796564) /locus_tag="BSU_18689" /old_locus_tag="BSU18689" /label="gene" CDS complement(1796604..1797359) /gene="yoaP" /locus_tag="BSU_18690" /old_locus_tag="BSU18690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389750.1" /db_xref="EnsemblGenomes-Gn:BSU18690" /db_xref="EnsemblGenomes-Tr:CAB13761" /db_xref="GOA:O34983" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR025685" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13486" /db_xref="UniProtKB/Swiss-Prot:O34983" /translation="MCYIEITKDNIEDNHICCALSTKQYEHAVNEKKRWLKARMDEGL VFYRLHERAKVFIEYLPANEAWVPINAPNFMYINCLWVSGRYKNNGHAKRLLDKCIAD AKACGMDGIIHIAGKKKLPYLSDKHFFEHMGFTLQDEAAPYFQLMALTWNGLADSPAF KSQVKSDSINEKGITIYYTAQCPFAVGMINDLRELTEKKGVQFQSIQLSSKEEAQKSP AIWTTFSVFFDGRFVTHEIMSINKFEKLLNTLA*" /label="yoaP CDS" gene complement(1796604..1797359) /gene="yoaP" /locus_tag="BSU_18690" /old_locus_tag="BSU18690" /label="yoaP gene" promotor_-35 1797612..1797617 /Source="Nicolas_upshift_promotors" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1797633..1797651 /Source="Nicolas_upshift_promotors" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1797648 /Source="Nicolas_upshifts" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="upshifts" CDS 1797667..1798023 /gene="yoaQ" /locus_tag="BSU_18700" /old_locus_tag="BSU18700" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389751.1" /db_xref="EnsemblGenomes-Gn:BSU18700" /db_xref="EnsemblGenomes-Tr:CAB13762" /db_xref="SubtiList:BG13487" /db_xref="UniProtKB/Swiss-Prot:O31831" /translation="MVEKCYSCLICGYKGLIQNPLYKGEYQKTFDICPCCGFEFGYSE DHDVRLGFIVTPDHLIEAAFQLYRKQWLESGMVIAHPEDIPEELKNGNCLKFEVLLKQ LKKLNLDIENFEISGF*" /label="yoaQ CDS" gene 1797667..1798023 /gene="yoaQ" /locus_tag="BSU_18700" /old_locus_tag="BSU18700" /label="yoaQ gene" CDS complement(1797982..1798221) /gene="yozT" /locus_tag="BSU_18709" /old_locus_tag="BSU18709" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (putative phage origin); putative defective prophage 6" /protein_id="YP_003097735.1" /db_xref="EnsemblGenomes-Gn:BSU18709" /db_xref="EnsemblGenomes-Tr:CAX52629" /db_xref="UniProtKB/Swiss-Prot:C0H421" /translation="MTVINDYREEPEEAFWILYPMGVKCLSMITKSLLNTNRDFVTDC AFQLNILLIMTVKPKQVQPVSSLKTANFKIFYVKI*" /label="yozT CDS" gene complement(1797982..1798221) /gene="yozT" /locus_tag="BSU_18709" /old_locus_tag="BSU18709" /label="yozT gene" S_feature 1798024..1798460 /Source="Nicolas_S_feature" /locus_tag="new_2041030_2041466" /HighExp="S8, S7, S4, S5, S6, S3, T5.0H, LoTm, BT, T4.0H" /AntisenseName="yozT" /AntisenseCor="0.93420248567111996" /AntisenseRegPval="-120.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S699" S_feature complement(1798222..1798323) /Source="Nicolas_S_feature" /locus_tag="new_2041228_2041329_c" /HighExp="S8, S7, S6, S5, S4, BT, ferm, nit, S3, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S700" CDS complement(1798324..1798821) /gene="yozF" /locus_tag="BSU_18710" /old_locus_tag="BSU18710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389752.2" /db_xref="EnsemblGenomes-Gn:BSU18710" /db_xref="EnsemblGenomes-Tr:CAB13763" /db_xref="SubtiList:BG13753" /db_xref="UniProtKB/Swiss-Prot:O31832" /translation="MKRVLFSVIVFTAVGFTFCQSKAHALTFTVLPITQKTDQWSVKV SEAKNVKEFTRPHKGEYQVYSLEVKNIGEKAATVDVQLYRNDPNSITRFSLFGCPDEN CVKPKEDSKMLAESLNDGSPLKFNHFMLADKASELEVVIIWTQKGQEGRNLKQTFKFT EDGVN*" /label="yozF CDS" gene complement(1798324..1798821) /gene="yozF" /locus_tag="BSU_18710" /old_locus_tag="BSU18710" /label="yozF gene" S_feature complement(1798822..1798921) /Source="Nicolas_S_feature" /locus_tag="new_2041828_2041927_c" /HighExp="S8, S7, S5, S6, S4, BT, ferm, nit, S3, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S701" CDS complement(1798922..1799833) /gene="yoaR" /locus_tag="BSU_18720" /old_locus_tag="BSU18720" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8631706; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor for cell wall maintenance or synthesis" /protein_id="NP_389753.1" /db_xref="EnsemblGenomes-Gn:BSU18720" /db_xref="EnsemblGenomes-Tr:CAB13764" /db_xref="InterPro:IPR007391" /db_xref="SubtiList:BG13488" /db_xref="UniProtKB/Swiss-Prot:O34611" /translation="MIQILITGLFLLAQPSEPQDSLTVTQQGRTIATVNREDFTMPLP GTPMVDYEKYSKFIKQLDQKVYREPINAVLNDHGSIVPGRVGYKLYQQAFMEKFYAYF YGQGPSKIEVPEMNIYPKVDSELLAHISTQQLGQYVTYFNSSNKSRSHNISLSAKAID NHVVFPNETFSFNQVVGMRTRNKGYKSAPIIVKGELSEGVGGGICQVSSTLFNAVDRA GLQIVQRYSHTRSVPYVPPGRDATVSWGGPDFRFQNQYNQPILIRAKRYGGSMIITLY SSDVINSRLRKIPKAPSRIPKEINAEQ*" /label="yoaR CDS" gene complement(1798922..1799833) /gene="yoaR" /locus_tag="BSU_18720" /old_locus_tag="BSU18720" /label="yoaR gene" promotor_-10 complement(1799855..1799866) /Source="Nicolas_upshift_promotors" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1799857) /Source="Nicolas_upshifts" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1799881..1799887) /Source="Nicolas_upshift_promotors" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1800117..1800124 /Source="Nicolas_upshift_promotors" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1800133 /Source="Nicolas_upshifts" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1800139..1800158 /Source="Nicolas_upshift_promotors" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1800180..1800662 /gene="yoaS" /locus_tag="BSU_18730" /old_locus_tag="BSU18730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19493340; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a toxin / antitoxin system" /protein_id="NP_389754.1" /db_xref="EnsemblGenomes-Gn:BSU18730" /db_xref="EnsemblGenomes-Tr:CAB13765" /db_xref="GOA:O31833" /db_xref="InterPro:IPR021354" /db_xref="SubtiList:BG13489" /db_xref="UniProtKB/Swiss-Prot:O31833" /translation="MNRMSTIFLKIALVLIGIPILALCIFLVPKVANYSAELFPNIAY IKYLVFIYLYVTAIPFYFALYQAFKLLSYIDKNKAFSGLSVRALKNIKYCAVTISIFY AAGMPVFYLMAEIDDAPGIIVIGLVIIFASMVIAVFAAVLQKLLKEAIDIKSENDLTV *" /label="yoaS CDS" gene 1800180..1800662 /gene="yoaS" /locus_tag="BSU_18730" /old_locus_tag="BSU18730" /label="yoaS gene" CDS 1800672..1800926 /gene="yozG" /locus_tag="BSU_18740" /old_locus_tag="BSU18740" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19493340; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative antitoxin of a toxin / antitoxin system; putative transcriptional regulator" /protein_id="NP_389755.1" /db_xref="EnsemblGenomes-Gn:BSU18740" /db_xref="EnsemblGenomes-Tr:CAB13766" /db_xref="GOA:O31834" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG13754" /db_xref="UniProtKB/Swiss-Prot:O31834" /translation="MAIIINIDVMLAKRKMSVTELSERVGITMANLSILKNGKAKAIR LSTLEAICKALECQPGDILEYRSDEDTGFVKKKYEGSTEK*" /label="yozG CDS" gene 1800672..1800926 /gene="yozG" /locus_tag="BSU_18740" /old_locus_tag="BSU18740" /label="yozG gene" S_feature 1800927..1801031 /Source="Nicolas_S_feature" /locus_tag="new_2043933_2044037" /HighExp="LoTm, B60, Sw, G135, G180, B36, LBGstat, Cold, LBGtran, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S702" CDS 1801032..1801826 /gene="yoaT" /locus_tag="BSU_18750" /old_locus_tag="BSU18750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389756.1" /db_xref="EnsemblGenomes-Gn:BSU18750" /db_xref="EnsemblGenomes-Tr:CAB13767" /db_xref="GOA:O34535" /db_xref="InterPro:IPR008535" /db_xref="SubtiList:BG13490" /db_xref="UniProtKB/Swiss-Prot:O34535" /translation="MRAIKQIVHFGWEQALSCLFPAVIFASLAITQIIPLPFLPRYDW LLIICVLMQLWMVRSGLETRDELKVITLFHLIGLALELFKVHMGSWSYPEEGYSKIFG VPLYSGFMYASVASYLCQAWRRLKVELVKWPSFFAVVPLAAAIYLNFFTHHFSIDIRW WLSGLVIIVFWQTWVTYEVNGARYRMPLALSFILIGFFIWIAENIATFFGAWKYPNQI DTWSLVHLGKVSSWLLLVIVSFLIVASLKQVKEQSPTKAEMDESFS*" /label="yoaT CDS" gene 1801032..1801826 /gene="yoaT" /locus_tag="BSU_18750" /old_locus_tag="BSU18750" /label="yoaT gene" S_feature 1801827..1802837 /Source="Nicolas_S_feature" /locus_tag="new_2044833_2045843" /HighExp="LoTm, Cold, Sw, H2O2, B60, GM 10, S8, dia15, T2.30H, MG 60" /AntisenseName="yoaU" /AntisenseCor="-2.6976304882719598E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S703" CDS complement(1801950..1802822) /gene="yoaU" /locus_tag="BSU_18760" /old_locus_tag="BSU18760" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17526699; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_389757.1" /db_xref="EnsemblGenomes-Gn:BSU18760" /db_xref="EnsemblGenomes-Tr:CAB13768" /db_xref="GOA:O34701" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13491" /db_xref="UniProtKB/Swiss-Prot:O34701" /translation="MVMNMNHLHIFVKVGEKLNITEAAKELFISQPAVSKAIKNLESS LQLKLLIRDKHHGLMLTDIGKEILLLARQMKGIESKIYQVANRENKLLNGKVKIGSFP AVSTNIMPQAIAAFRSNYPLIRIELIEGTSDQIKGWVEDRTVDIGIAASPFEPFENQL LCNDYMVAVIPPQRDELKLEKHVDLETYQDDLIFCKGGHEIAMSNAFSQYNIELKENL TVQNAETLINMVKNNLGIGIISNFTLSSVPHQLIKKDIFPRVTRDIGVIAHSFEEITP AAHEFVKVLKAVVI*" /label="yoaU CDS" gene complement(1801950..1802822) /gene="yoaU" /locus_tag="BSU_18760" /old_locus_tag="BSU18760" /label="yoaU gene" CDS 1802923..1803801 /gene="yoaV" /locus_tag="BSU_18770" /old_locus_tag="BSU18770" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10844694, 11717295, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative modified amino acid or TCA compound efflux permease" /protein_id="NP_389758.1" /db_xref="EnsemblGenomes-Gn:BSU18770" /db_xref="EnsemblGenomes-Tr:CAB13769" /db_xref="GOA:O34416" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG13492" /db_xref="UniProtKB/Swiss-Prot:O34416" /translation="MVKVMLGIISVTLIWGYTWVAMKVGIHDIPPLLFSGLRLFIGAV PLFLILFIQRKKLSIQKEHLKSYIIMSLLMGLGYMGILTYGMQFVDSGKTSVLVYTMP IFVTVISHFSLNEKMNVYKTMGLVCGLFGLLFIFGKEMLNIDQSALFGELCVLVAALS WGIANVFSKLQFKHIDIIHMNAWHLMMGAVMLLVFSFIFEAVPSAEWTYQAVWSLLFN GLLSTGFTFVVWFWVLNQIQASKASMALMFVPVLALFFGWLQLHEQITINIILGALLI CCGIFMNTFTFSRRKV*" /label="yoaV CDS" gene 1802923..1803801 /gene="yoaV" /locus_tag="BSU_18770" /old_locus_tag="BSU18770" /label="yoaV gene" S_feature complement(1803914..1803973) /Source="Nicolas_S_feature" /locus_tag="new_2046920_2046979_c" /HighExp="BC, T4.0H, M9-stat, S5, T5.0H, S4, S3, T3.0H, T3.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.167154" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S704" downshifts complement(1803949) /Source="Nicolas_upshifts" /id="D1026" /incds=0 /nref=55 /ntot=175 /MaxReadThrough="1.78313" /MaxDrop="5.17096" /score="15.465237" /energy="-12.3" /TU="NA" /idTUdmin="U1518" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1803974..1804405) /gene="yoaW" /locus_tag="BSU_18780" /old_locus_tag="BSU18780" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15101989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="biofilm forming exported protein" /protein_id="NP_389759.1" /db_xref="EnsemblGenomes-Gn:BSU18780" /db_xref="EnsemblGenomes-Tr:CAB13770" /db_xref="SubtiList:BG13493" /db_xref="UniProtKB/Swiss-Prot:O34541" /translation="MKKMLMLAFTFLLALTIHVGEASAVIVKDEEKVSFTMTENEKWF MKSDDLNSNHWTSHFGYRFTIFDTEGCTINARIMRMTLSGYEITVSEKNFSGDHFDFS ATDRVETMPYKTHYLILTKDPDCGDVKVKGLYGFQFDQPEW*" /label="yoaW CDS" gene complement(1803974..1804405) /gene="yoaW" /locus_tag="BSU_18780" /old_locus_tag="BSU18780" /label="yoaW gene" promotor_-10 complement(1804425..1804444) /Source="Nicolas_upshift_promotors" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1804433) /Source="Nicolas_upshifts" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1804435..1804668) /Source="Nicolas_S_feature" /locus_tag="new_2047441_2047674_c" /HighExp="S4, S3, S5, S7, S8, S6, LoTm, T5.0H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S705" promotor_-35 complement(1804458..1804464) /Source="Nicolas_upshift_promotors" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1804669..1804687) /Source="Nicolas_upshift_promotors" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1804669..1805301) /gene="yoaZ" /locus_tag="BSU_18790" /old_locus_tag="BSU18790" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16181642; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor of the oxidative stress response" /protein_id="NP_389760.1" /db_xref="EnsemblGenomes-Gn:BSU18790" /db_xref="EnsemblGenomes-Tr:CAB13771" /db_xref="GOA:O34947" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13494" /db_xref="UniProtKB/Swiss-Prot:O34947" /translation="MQTRKVYLYVFHTMSDWEYGYLIAELNSGRYFKQDAASLKVVTV GVNKEMITTLGGLSIKPDISLDECTLGSQDLIILPGGNTWGEDIHQPILKKVGDALKL GTTIAAICGATLGLANEGYLNSRKHTSNDLDYMNMVCPNYKGETFYEKGPAVSDENLV TASGIAPLEFAVEVLKKLDVFAPDTLRSWYKLNKTQKPEYFFELMNTINR*" /label="yoaZ CDS" gene complement(1804669..1805301) /gene="yoaZ" /locus_tag="BSU_18790" /old_locus_tag="BSU18790" /label="yoaZ gene" upshifts complement(1804675) /Source="Nicolas_upshifts" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1804703..1804708) /Source="Nicolas_upshift_promotors" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1805439..1805446 /Source="Nicolas_upshift_promotors" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1805461..1805480 /Source="Nicolas_upshift_promotors" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1805465 /Source="Nicolas_upshifts" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="upshifts" CDS 1805527..1806447 /gene="penP" /locus_tag="BSU_18800" /old_locus_tag="BSU18800" /EC_number="3.5.2.6" /function="16.5: Explore" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7789815, 15187182, 16944130, 22211522, 25112476, 25355936; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="beta-lactamase precursor (putative hydrolase)" /protein_id="NP_389761.1" /db_xref="EnsemblGenomes-Gn:BSU18800" /db_xref="EnsemblGenomes-Tr:CAB13772" /db_xref="GOA:P39824" /db_xref="InterPro:IPR000871" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023650" /db_xref="SubtiList:BG11016" /db_xref="UniProtKB/Swiss-Prot:P39824" /translation="MKLKTKASIKFGICVGLLCLSITGFTPFFNSTHAEAKSIEDTNM ASCITNKKFVQLEKKFDARLGVYAIDIGSNKTIAYRPNERFAYASTYKVLAAAAVLKK NSIEKLNEVIHYSKDDLVTYSPITEKHLDTGMSLKEISEAAIRYSDNTAGNILLQQLG GPKGFEKSLKQIGDHVTKAKRFETDLNSAIPGDIRDTSTAKALATDLKAFTLDNTLTT DKRMILTDWMRGNATGDELIRAGAPIGWEVGDKSGAGSYGTRNDIAIVWPPNRAPIVV AILSNRFTKDANYDNALIAEAAKVVLNDLK*" /label="penP CDS" gene 1805527..1806447 /gene="penP" /locus_tag="BSU_18800" /old_locus_tag="BSU18800" /label="penP gene" promotor_-10 complement(1805958..1805977) /Source="Nicolas_upshift_promotors" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1805973) /Source="Nicolas_upshifts" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1805992..1805999) /Source="Nicolas_upshift_promotors" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1806448..1807105 /Source="Nicolas_S_feature" /locus_tag="new_2049454_2050111" /HighExp="HiOs, S8, GM 25, GM 15, GM-0.1, C30, S2, S1, BC, GM 45" /AntisenseName="yobA" /AntisenseCor="8.9918765131424994E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S706" CDS complement(1806944..1807306) /gene="yobA" /locus_tag="BSU_18810" /old_locus_tag="BSU18810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389762.1" /db_xref="EnsemblGenomes-Gn:BSU18810" /db_xref="EnsemblGenomes-Tr:CAB13773" /db_xref="InterPro:IPR021598" /db_xref="PDB:2JQO" /db_xref="PDB:4QY7" /db_xref="SubtiList:BG13495" /db_xref="UniProtKB/Swiss-Prot:O31835" /translation="MPKIGVSLIVLIMLIIFLAGCNKNEQNGDETKMQSLVGYVVLKD NERAILITDTKAPGKEDYNLSEGQLMNKFKNNIVIVGLSEIDNTDDLKRGEKIKVWFH TRKESNPPSATIQKYELL*" /label="yobA CDS" gene complement(1806944..1807306) /gene="yobA" /locus_tag="BSU_18810" /old_locus_tag="BSU18810" /label="yobA gene" CDS complement(1807367..1807579) /gene="yozU" /locus_tag="BSU_18819" /old_locus_tag="BSU18819" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type h : extrachromosomal origin" /pseudo /codon_start=1 /transl_table=11 /product="putative phage protein" /db_xref="PSEUDO:CAX52630.1" /translation="MEVAIVNDSKDKYIYAGIQKEAAFNNIFESAKMSKRIISRATTC KYLRKNKKKVEELENEYAAVMNCKKK*" /label="yozU CDS" gene complement(1807367..1807579) /gene="yozU" /locus_tag="BSU_18819" /old_locus_tag="BSU18819" /pseudo /label="yozU gene" promotor_-35 1807618..1807625 /Source="Nicolas_upshift_promotors" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1807640..1807659 /Source="Nicolas_upshift_promotors" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1807643 /Source="Nicolas_upshifts" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="upshifts" CDS 1807683..1807946 /gene="yobB" /locus_tag="BSU_18820" /old_locus_tag="BSU18820" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10376821; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator from bacteriophage; putative defective prophage 6" /protein_id="NP_389763.1" /db_xref="EnsemblGenomes-Gn:BSU18820" /db_xref="EnsemblGenomes-Tr:CAB13774" /db_xref="SubtiList:BG13496" /db_xref="UniProtKB/Swiss-Prot:O31836" /translation="MKIRKILLSSALSFGMLISAVPALAAGTSSEVAVKNEEYDYDTI YRISPLPMDFQPTIEYNGYTYTLTRHYFDYSIGFYTAIYTKVV*" /label="yobB CDS" gene 1807683..1807946 /gene="yobB" /locus_tag="BSU_18820" /old_locus_tag="BSU18820" /label="yobB gene" downshifts 1807924 /Source="Nicolas_upshifts" /id="D1027" /incds=0 /nref=23 /ntot=100 /MaxReadThrough="0.60454" /MaxDrop="4.81085" /score="19.5390064" /energy="-8.7" /TU="NA" /idTUdmin="U1522" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(1808323..1810923) /gene="yppS" /locus_tag="BSU_18830" /old_locus_tag="BSU18830" /EC_number="2.7.9.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative PEP-dependent enzyme" /protein_id="NP_389764.1" /db_xref="EnsemblGenomes-Gn:BSU18830" /db_xref="EnsemblGenomes-Tr:CAB13775" /db_xref="GOA:O34309" /db_xref="InterPro:IPR002192" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR013815" /db_xref="SubtiList:BG12657" /db_xref="UniProtKB/Swiss-Prot:O34309" /translation="MSSLVLGLHEIEKTQLSLVGGKGLHLGELSKIQGIQVPEGFCVT TVGYQKAIEQNETLQVLLDQLTMLKVEDRDQIGNISRKIRQIIMEVDIPSDVVKAVAQ YLSQFGEEHAYAVRSSATAEDLPHASFAGQQDTYLNITGVDAILQHISKCWASLFTDR AVIYRMQNGFDHSQVYLSVIVQRMVFPQASGILFTADPITSNRKVLSIDAGFGLGEAL VSGLVSADCFKVQDGQIIDKRIATKKMAIYGRKEGGTETQQIDSDQQKAQTLTDEQIL QLARIGRQIEAHFGQPQDIEWCLARDTFYIVQSRPITTLFPIPEASDQENHVYISVGH QQMMTDPIKPLGLSFFLLTTVAPMRKAGGRLFVDVTHHLASPDSREVFLKGMGQHDQL LKDALMTIIKRRDFIKSIPNDKTAPNPSRGNADMPAQVENDPTIVSDLIESSQTSIEE LKQNIQTKSGSDLFRFILEDIQELKKILFNPKSSVLIRTAMNASLWINEKMNEWLGEK NAADTLSQSVPHNITSEMGLALLDVADVIRPYPEVIDYLQHVKDDNFLDELAKFDGGS KTRDAIYDYLSKYGMRCTGEIDITRTRWSEKPTTLVPMILNNIKNFEPNVGHRKFEQG RQEALKKEQELLDRLKQLPDGEQKAKETKRAIDIIRNFSGFREYPKYGMVNRYFVYKQ ALLKEAEQLIEAGVIHEKEDIYYLTFEELHEVVRTHKLDYQIISTRKDEYTLYEKLSP PRVITSDGEIVTGEYKRENLPAGAIVGLPVSSGVIEGRARVILNMEDADLEDGDILVT SFTDPSWTPLFVSIKGLVTEVGGLMTHGAVIAREYGLPAVVGVENAAKLIKDGQRIRV HGTEGYIEIF*" /label="yppS CDS" gene complement(1808323..1810923) /gene="yppS" /locus_tag="BSU_18830" /old_locus_tag="BSU18830" /label="yppS gene" S_feature complement(1810924..1811033) /Source="Nicolas_S_feature" /locus_tag="new_2053930_2054039_c" /HighExp="dia15, BC, S6, SMMPr, H2O2, S5, T-5.40H, S4, HPh, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S707" promotor_-35 1810949..1810956 /Source="Nicolas_upshift_promotors" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1810971..1810990 /Source="Nicolas_upshift_promotors" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1810979..1811606 /Source="Nicolas_S_feature" /locus_tag="new_2053985_2054612" /HighExp="T5.0H, T4.0H, T3.30H, T3.0H, S1, T2.30H, Heat, S2, T-5.40H, C30" /AntisenseName="xynA" /AntisenseCor="-0.30871986344497798" /AntisenseRegPval="-6.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S708" upshifts 1810979 /Source="Nicolas_upshifts" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1811023..1811042) /Source="Nicolas_upshift_promotors" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1811033) /Source="Nicolas_upshifts" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1811057..1811063) /Source="Nicolas_upshift_promotors" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1811079..1811538) /Source="Nicolas_S_feature" /locus_tag="new_2054085_2054544_c" /HighExp="S0, Lbstat, HiTm, dia0, ferm, Lbexp, T1.0H, M0t45, LBGtran, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.985" /label="S709" downshifts complement(1811121) /Source="Nicolas_upshifts" /id="D1028" /incds=0 /nref=87 /ntot=200 /MaxReadThrough="1.89557" /MaxDrop="5.26144" /score="1.97345986" /energy="-10.4" /TU="NA" /idTUdmin="U1525" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1811583) /Source="Nicolas_upshifts" /id="D1029" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="5.28207" /MaxDrop="3.16026" /score="1.97345986" /energy="-10.4" /TU="U1525" /idTUdmin="U1525" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS complement(1811593..1812234) /gene="xynA" /locus_tag="BSU_18840" /old_locus_tag="BSU18840" /EC_number="3.2.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7704256, 8628241, 16517552, 26559526" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7704256, 8628241, 16517552, 26559526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted endo-1,4-beta-xylanase" /protein_id="NP_389765.1" /db_xref="EnsemblGenomes-Gn:BSU18840" /db_xref="EnsemblGenomes-Tr:CAB13776" /db_xref="GOA:P18429" /db_xref="InterPro:IPR001137" /db_xref="InterPro:IPR013319" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018208" /db_xref="InterPro:IPR033119" /db_xref="InterPro:IPR033123" /db_xref="PDB:1AXK" /db_xref="PDB:1XXN" /db_xref="PDB:2B42" /db_xref="PDB:2B45" /db_xref="PDB:2B46" /db_xref="PDB:2DCY" /db_xref="PDB:2DCZ" /db_xref="PDB:2QZ3" /db_xref="PDB:2Z79" /db_xref="PDB:3EXU" /db_xref="PDB:3HD8" /db_xref="PDB:5K9Y" /db_xref="SubtiList:BG10808" /db_xref="UniProtKB/Swiss-Prot:P18429" /translation="MFKFKKNFLVGLSAALMSISLFSATASAASTDYWQNWTDGGGIV NAVNGSGGNYSVNWSNTGNFVVGKGWTTGSPFRTINYNAGVWAPNGNGYLTLYGWTRS PLIEYYVVDSWGTYRPTGTYKGTVKSDGGTYDIYTTTRYNAPSIDGDRTTFTQYWSVR QSKRPTGSNATITFSNHVNAWKSHGMNLGSNWAYQVMATEGYQSSGSSNVTVW*" /label="xynA CDS" gene complement(1811593..1812234) /gene="xynA" /locus_tag="BSU_18840" /old_locus_tag="BSU18840" /label="xynA gene" S_feature complement(1812235..1812352) /Source="Nicolas_S_feature" /locus_tag="new_2055241_2055358_c" /HighExp="S0, HiTm, T1.0H, Gly, Lbstat, SMMPr, Lbtran, LBGstat, SMM, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.985" /label="S710" promotor_-10 complement(1812329..1812348) /Source="Nicolas_upshift_promotors" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1812352) /Source="Nicolas_upshifts" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1812362..1812364) /Source="Nicolas_upshift_promotors" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="promotor_-35" SCAR join(1812440,1812447) /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="IIG_Bs05" N_region 1812441..1812446 /note="SacI site (GAGCTC)" /modified_by="User" /label="IIG_Bs05" misc_RNA <1812447..1812531 /gene="bsrF" /locus_tag="BSU_misc_RNA_75" /product="small untranslated regulatory RNA" /experiment="publication(s) with functional evidences, PMID:18948176, 19542274" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176, 19542274; Product type n: RNA" /label="bsrF RNA" S_feature <1812447..1812524 /Source="Nicolas_S_feature" /locus_tag="new_2079086_2079196" /HighExp="LoTm, S7, HPh, LPhT, S8, BT, S6, G/S, S0, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="0.896, 1" /TUlongSig="SigEF" /TUlongPSig="0.995" /label="S728" S_feature complement(<1812447..1812511) /Source="Nicolas_S_feature" /locus_tag="new_2078548_2079183_c" /HighExp="MG 150, S8, MG 120, S7, MG 90, GM-0.1, Glu, Fru, GM-0.2, GM 5" /AntisenseName="yobO" /AntisenseCor="0.134597835896198" /AntisenseRegPval="-1.6" /CDS_PredictionProba="0.40121099999999998" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S726" gene <1812447..1812531 /gene="bsrF" /old_locus_tag="BSU_misc_RNA_75" /locus_tag="PG10_pseudo_BSU_misc_RNA_75" /modified_by="User" /label="PG10_pseudo_BSU_misc_RNA_75" downshifts 1812509 /Source="Nicolas_upshifts" /id="D1044" /incds=0 /nref=65 /ntot=254 /MaxReadThrough="1.60135" /MaxDrop="9.06442" /score="30.7999406" /energy="-13.9" /TU="NA" /idTUdmin="U1545" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1812542..1812874) /gene="csaA" /locus_tag="BSU_19040" /old_locus_tag="BSU19040" /function="16.1: Circulate" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10658654, 10816431, 13129613, 15856219, 17372352, 28724440; Product type f : factor" /codon_start=1 /transl_table=11 /product="molecular chaperone for secreting proteins" /protein_id="NP_389785.1" /db_xref="EnsemblGenomes-Gn:BSU19040" /db_xref="EnsemblGenomes-Tr:CAB13796" /db_xref="GOA:P37584" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR008231" /db_xref="InterPro:IPR012340" /db_xref="PDB:2NZH" /db_xref="PDB:2NZO" /db_xref="SubtiList:BG10809" /db_xref="UniProtKB/Swiss-Prot:P37584" /translation="MAVIDDFEKLDIRTGTIVKAEEFPEARVPAIKLVIDFGTEIGIK QSSAQITKRYKPEGLINKQVIAVVNFPPRRIAGFKSEVLVLGGIPGQGDVVLLQPDQP VPNGTKIG*" /label="csaA CDS" gene complement(1812542..1812874) /gene="csaA" /locus_tag="BSU_19040" /old_locus_tag="BSU19040" /label="csaA gene" downshifts complement(1812556) /Source="Nicolas_upshifts" /id="D1045" /incds=0 /nref=28 /ntot=228 /MaxReadThrough="4.42209" /MaxDrop="5.706" /score="-8.98970984" /energy="-13.9" /TU="U1547" /idTUdmin="U1550" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1812939..1813664) /gene="yobQ" /locus_tag="BSU_19050" /old_locus_tag="BSU19050" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478, 27038276; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_389786.1" /db_xref="EnsemblGenomes-Gn:BSU19050" /db_xref="EnsemblGenomes-Tr:CAB13797" /db_xref="GOA:O34901" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG13508" /db_xref="UniProtKB/Swiss-Prot:O34901" /translation="MLMDSLQEIICEKRTYTRLYHSHKHAYSQFLFPLEGSIDLETEG RQVKLNPDHFLYIPPQCEHRFRSIGRNECLVLDVPLHAMKIDEYRAGSGIEAALDPFW SSIRYLLTEEAKAGTANSLHMLVQYIKEKLQSHSYASIAYIHSHLFERLTIKKLAEIE HYHPAYYSSWFKKQTGKSPQNYIADLRLEEAKRMLMERNETLTVVSEALGFQNLSSFT RWFTKSTGMPPRLYRNTLYSDKK*" /label="yobQ CDS" gene complement(1812939..1813664) /gene="yobQ" /locus_tag="BSU_19050" /old_locus_tag="BSU19050" /label="yobQ gene" CDS complement(1813679..1814422) /gene="yobR" /locus_tag="BSU_19060" /old_locus_tag="BSU19060" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389787.1" /db_xref="EnsemblGenomes-Gn:BSU19060" /db_xref="EnsemblGenomes-Tr:CAB13798" /db_xref="GOA:O34376" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13509" /db_xref="UniProtKB/Swiss-Prot:O34376" /translation="MDDIRKIERLAAASWPAYFQKSIGKWLLRANFGVTKRANSVWTS ADMPEGDFQLEAELFYQSLGLPVCFHISNASPKGLDDALADSRYEKVDECFQMTALCR SIMSRTNDNSRFTYKWEQEPSSVWIDEFIQLEGFSPERHKGYKHIFERMPPCKTFFKM YDKESLTALGTVSVIDGYGGLSNIVVAEEHRGKGAGTQVIRVLTEWAKNNGAERMFLQ VMKENLAAVSLYGKIGFSPISEHHYRIKR*" /label="yobR CDS" gene complement(1813679..1814422) /gene="yobR" /locus_tag="BSU_19060" /old_locus_tag="BSU19060" /label="yobR gene" promotor_-10 complement(1814450..1814469) /Source="Nicolas_upshift_promotors" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1814469) /Source="Nicolas_upshifts" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1814483..1814489) /Source="Nicolas_upshift_promotors" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1814500..1815075) /gene="yobS" /locus_tag="BSU_19070" /old_locus_tag="BSU19070" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_389788.1" /db_xref="EnsemblGenomes-Gn:BSU19070" /db_xref="EnsemblGenomes-Tr:CAB13799" /db_xref="GOA:O34892" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025996" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG13510" /db_xref="UniProtKB/Swiss-Prot:O34892" /translation="MSPRIGLTQKMIVDAAAEIADQEGVNGVSLAALSKKMNVRPPSL YNHINGLQAIRAELAVRGLTKLFDQMADSVTERKGDSAMLSLAHAYVDFAIENPGYYE AALLKVHDKRTEIVSDQIVCLVTKLLIENGYASEKTAIHATRGLRSLLHGFTVLIAKE AFEREEDILESLSFSIRTFLSGLLINNKNIM*" /label="yobS CDS" gene complement(1814500..1815075) /gene="yobS" /locus_tag="BSU_19070" /old_locus_tag="BSU19070" /label="yobS gene" CDS complement(1815081..1815782) /gene="yobT" /locus_tag="BSU_19080" /old_locus_tag="BSU19080" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_389789.1" /db_xref="EnsemblGenomes-Gn:BSU19080" /db_xref="EnsemblGenomes-Tr:CAB13800" /db_xref="GOA:O34910" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13511" /db_xref="UniProtKB/Swiss-Prot:O34910" /translation="MRITQYQTVWQLTFFPALFPVNCYLVEEENEVTLIDAALPGSYK GIIQAVNQLGKPLQHILLTHAHGDHVGSLDTLAQTFPHAKVMISERDSFLLQGDTSLR QDEPQTPIKGGIPKHIQTKPHQLLTGGETIGSLLAIPTPGHTPGSMSFLDTRNGTLIA GDAFQLRGGIAVSGQIKWAFPFPAFATWNKEEAIKSAQLLADKAPSCLAVGHGKFLRS PSERMRQAIQKAKKG*" /label="yobT CDS" gene complement(1815081..1815782) /gene="yobT" /locus_tag="BSU_19080" /old_locus_tag="BSU19080" /label="yobT gene" promotor_-10 complement(1815812..1815831) /Source="Nicolas_upshift_promotors" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1815812) /Source="Nicolas_upshifts" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1815816..1815831) /Source="Nicolas_upshift_promotors" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1815846..1815853) /Source="Nicolas_upshift_promotors" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1815846..1815853) /Source="Nicolas_upshift_promotors" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1815856) /Source="Nicolas_upshifts" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1815859..1816341) /gene="yobU" /locus_tag="BSU_19090" /old_locus_tag="BSU19090" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative effector of transcriptional regulator" /protein_id="NP_389790.1" /db_xref="EnsemblGenomes-Gn:BSU19090" /db_xref="EnsemblGenomes-Tr:CAB13801" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG13512" /db_xref="UniProtKB/Swiss-Prot:O34637" /translation="MGFSHITHLDLKRFAGLSQRTSNALEMTEERRIPALWDQLWKQD MSALLSQAEKDKSIIALYSNYEQETNGFYTFSVGTFQEYDDILPGPYENIDLPASAYA VFTSRIGPIEEIVLETWKEIWTWDKRHLRTFTGDFEMYDQNAAVPQRAQVNIYVAIKK *" /label="yobU CDS" gene complement(1815859..1816341) /gene="yobU" /locus_tag="BSU_19090" /old_locus_tag="BSU19090" /label="yobU gene" misc_feature complement(1816380..1816397) /Source="Nicolas_upshift_promotors" /id="U1550" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.334665334665335" /psig="0.334665334665335" /xcortree=1509 /SigmaFactorBS="ataaagtaaaagaaaccattcatcacatgcaaaaaatatatg aaaccTGACACACTGCTGTCAGGtttctttgtctataatcttaaaaaaaggaggagat c" /listShort="yobU, yobT, yobS, yobR, yobQ, csaA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1816384) /Source="Nicolas_upshifts" /id="U1550" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.334665334665335" /psig="0.334665334665335" /xcortree=1509 /SigmaFactorBS="ataaagtaaaagaaaccattcatcacatgcaaaaaatatatg aaaccTGACACACTGCTGTCAGGtttctttgtctataatcttaaaaaaaggaggagat c" /listShort="yobU, yobT, yobS, yobR, yobQ, csaA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1816395..1817336) /gene="yobV" /locus_tag="BSU_19100" /old_locus_tag="BSU19100" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_389791.1" /db_xref="EnsemblGenomes-Gn:BSU19100" /db_xref="EnsemblGenomes-Tr:CAB13802" /db_xref="GOA:O34920" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR026881" /db_xref="InterPro:IPR028349" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13513" /db_xref="UniProtKB/Swiss-Prot:O34920" /translation="MKLERLLAMVVLLISKKQVQAAELAELFEVSVRTIYRDIETINR AGIPIVTSQGSGGGIGIMETYRLEREWLKEEELFAIASALQSVSSMYEPVSHSTAYQK IKHLIPEQSTQAFKHQTEKWFIDMTAWGHTEDQKTLREKISAAIDRLLTISFTYTSAS GETLLRETEPYTLVCKAGHWYLYAYCLVRNDFRFFKLNRMKDLAILHQTFIRKDIQLD TLPWDKSWYQKDRLTELVILVQPSARQRIGEWFGYDVLHCCEEDEICQAVISLPEDQW LIGFLLQFGKDIEVLQPLHIRDKVKETIHHMQKIYET*" /label="yobV CDS" gene complement(1816395..1817336) /gene="yobV" /locus_tag="BSU_19100" /old_locus_tag="BSU19100" /label="yobV gene" downshifts complement(1816428) /Source="Nicolas_upshifts" /id="D1046" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="0.95712" /MaxDrop="3.62763" /score="-3.71616684" /energy="-9" /TU="NA" /idTUdmin="U1548" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1817366..1817385) /Source="Nicolas_upshift_promotors" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1817374) /Source="Nicolas_upshifts" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1817399..1817403) /Source="Nicolas_upshift_promotors" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1817407..1817416 /Source="Nicolas_upshift_promotors" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1817429..1817448 /Source="Nicolas_upshift_promotors" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1817437 /Source="Nicolas_upshifts" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="upshifts" S_feature 1817452..1817516 /Source="Nicolas_S_feature" /locus_tag="new_2084124_2084188" /HighExp="BT, S7, B36, S8, S6, Pyr, G/S, B60, Glucon, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S729" promotor_-35 1817488..1817493 /Source="Nicolas_upshift_promotors" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1817509..1817527 /Source="Nicolas_upshift_promotors" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1817518 /Source="Nicolas_upshifts" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="upshifts" CDS 1817542..1818087 /gene="yobW" /locus_tag="BSU_19110" /old_locus_tag="BSU19110" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8990290, 11717295, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990290, 11717295, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="mother cell-specific membrane sporulation protein" /protein_id="NP_389792.1" /db_xref="EnsemblGenomes-Gn:BSU19110" /db_xref="EnsemblGenomes-Tr:CAB13803" /db_xref="GOA:P94497" /db_xref="InterPro:IPR014743" /db_xref="SubtiList:BG12269" /db_xref="UniProtKB/Swiss-Prot:P94497" /translation="MHLTLQSVYPAIIIIFFLYKKIKRSIGYQPLKPRWLFTRIILFS LFAFGLSIFSAIHPFLYGYLILGILGGWLLVFFAKKNISFEKRRGKIYFRTHIWVEVI LLTLFLSRFLYRVTELYLTSPDLNRLGSYSQSIGTDPLTIGVCFLIAVYYIGFSSFII KLSRNELEQHEYNKEKDILAR*" /label="yobW CDS" gene 1817542..1818087 /gene="yobW" /locus_tag="BSU_19110" /old_locus_tag="BSU19110" /label="yobW gene" downshifts 1818046 /Source="Nicolas_upshifts" /id="D1047" /incds=0 /nref=20 /ntot=63 /MaxReadThrough="3.56215" /MaxDrop="4.5413" /score="-4.21976438" /energy="-17.7" /TU="U1552,U1553" /idTUdmin="U1552" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" CDS complement(1818114..1818437) /gene="czrA" /locus_tag="BSU_19120" /old_locus_tag="BSU19120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15948947, 16406068, 16430705, 19170879, 19995076, 25213752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15948947, 16406068, 16430705, 19170879, 19995076, 25213752; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (multiple metal-sensing ArsR-SmtB transcriptional repressor favouring Zn2+)" /protein_id="NP_389793.1" /db_xref="EnsemblGenomes-Gn:BSU19120" /db_xref="EnsemblGenomes-Tr:CAB13804" /db_xref="GOA:O31844" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13748" /db_xref="UniProtKB/Swiss-Prot:O31844" /translation="MTEFRETEQSAADLDEETLFLVAQTFKALSDPTRIRILHLLSQG EHAVNGIAEKLNLLQSTVSHQLRFLKNLRLVKSRREGTSIYYSPEDEHVLDVLQQMIH HTQHD*" /label="czrA CDS" gene complement(1818114..1818437) /gene="czrA" /locus_tag="BSU_19120" /old_locus_tag="BSU19120" /label="czrA gene" downshifts complement(1818121) /Source="Nicolas_upshifts" /id="D1048" /incds=0 /nref=73 /ntot=252 /MaxReadThrough="1.89304" /MaxDrop="4.873" /score="17.3750937" /energy="-18.6" /TU="NA" /idTUdmin="U1554" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1818458..1818477) /Source="Nicolas_upshift_promotors" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1818469) /Source="Nicolas_upshifts" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1818490..1818497) /Source="Nicolas_upshift_promotors" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1818558..1818564 /Source="Nicolas_upshift_promotors" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1818575 /Source="Nicolas_upshifts" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1818579..1818598 /Source="Nicolas_upshift_promotors" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1818631..1819308 /gene="yocA" /locus_tag="BSU_19130" /old_locus_tag="BSU19130" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871, 20400549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative murein fragments glycosidase" /protein_id="NP_389794.1" /db_xref="EnsemblGenomes-Gn:BSU19130" /db_xref="EnsemblGenomes-Tr:CAB13805" /db_xref="GOA:O34636" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG13514" /db_xref="UniProtKB/Swiss-Prot:O34636" /translation="MKKKRKGCFAAAGFMMIFVFVIASFLLVLLFFNRDLIKKLPIDT KTIVLERLTDYKPLVEEELESQGLSNYTSLILGMMYQESKGKGNDPMQSSESLGLKRN EITDPQLSVKQGIKQFTLMYKTGKEKGVDLDTIIQSYNMGAGYIDFVAEHGGTHTEEL AKQYSEQQVKKNPDLYTCGGNAKNFRYPYCYGDYTYAEKVKEKTKTVEESLQVATLET MESKAHE*" /label="yocA CDS" gene 1818631..1819308 /gene="yocA" /locus_tag="BSU_19130" /old_locus_tag="BSU19130" /label="yocA gene" downshifts 1819300 /Source="Nicolas_upshifts" /id="D1049" /incds=0 /nref=207 /ntot=268 /MaxReadThrough="3.9729" /MaxDrop="8.52704" /score="-4.21976438" /energy="-17.7" /TU="U1555" /idTUdmin="U1555" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(1819398..1819934) /gene="yozB" /locus_tag="BSU_19140" /old_locus_tag="BSU19140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19222757, 24214949; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389795.1" /db_xref="EnsemblGenomes-Gn:BSU19140" /db_xref="EnsemblGenomes-Tr:CAB13806" /db_xref="GOA:O31845" /db_xref="InterPro:IPR007352" /db_xref="InterPro:IPR013833" /db_xref="SubtiList:BG13749" /db_xref="UniProtKB/Swiss-Prot:O31845" /translation="MNQTENKPKNYTGIVLTLTVLINGLIAVLFFMPKLDQFSHANIH ILPMLNAIFNSFTFIFLLAALIMIKQKNIKAHKRFILAAFTTTLLFLICYVTYHSIAE NTLYGGEGIMRPIYFFILITHICLSAIIVPLALFTLIRGFSMQVERHKKIARWTMPLW LYVSLTGVIVYLMISPYY*" /label="yozB CDS" gene complement(1819398..1819934) /gene="yozB" /locus_tag="BSU_19140" /old_locus_tag="BSU19140" /label="yozB gene" downshifts complement(1819421) /Source="Nicolas_upshifts" /id="D1050" /incds=0 /nref=175 /ntot=250 /MaxReadThrough="4.33842" /MaxDrop="7.96098" /score="14.7470642" /energy="-7.7" /TU="U1556" /idTUdmin="U1557" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1819961..1819980) /Source="Nicolas_upshift_promotors" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1819981) /Source="Nicolas_upshifts" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1819994..1820001) /Source="Nicolas_upshift_promotors" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1820071..1820853) /gene="yocB" /locus_tag="BSU_19150" /old_locus_tag="BSU19150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717291, 16291680" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389796.1" /db_xref="EnsemblGenomes-Gn:BSU19150" /db_xref="EnsemblGenomes-Tr:CAB13807" /db_xref="SubtiList:BG13515" /db_xref="UniProtKB/Swiss-Prot:O34516" /translation="MAIDSLINKLQYVQLEPPDKILSLYLNTDMRDPEQQGGEWKIAL KSGFSRLKEYLAASDPEEEKCLDGIRAKMNQYLNAMGKDMPRSLVFFVSDSGIWEPIK LQVPVDTRFYWEETAVLDQLKGLRQTYPSTAFILTQQHEVKIIETVLGKIEAVERYEY DMINESWKNSHSAVDKAPPFEENRMREHVTENQSRLYKRLAASLDQKAAAKRWERMVI AGDKETADILDQHMNKPIHSKIQKNLLNENEHKVIEHLIKEA*" /label="yocB CDS" gene complement(1820071..1820853) /gene="yocB" /locus_tag="BSU_19150" /old_locus_tag="BSU19150" /label="yocB gene" downshifts complement(1820080) /Source="Nicolas_upshifts" /id="D1051" /incds=0 /nref=3 /ntot=38 /MaxReadThrough="5.37496" /MaxDrop="4.00348" /score="14.7470642" /energy="-7.7" /TU="U1557" /idTUdmin="U1557" /TUdmin="-660" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1820875..1820893) /Source="Nicolas_upshift_promotors" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1820894) /Source="Nicolas_upshifts" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1820907..1820913) /Source="Nicolas_upshift_promotors" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1820950..1820957 /Source="Nicolas_upshift_promotors" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="promotor_-35" promotor_-10 1820972..1820991 /Source="Nicolas_upshift_promotors" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="promotor_-10" upshifts 1820976 /Source="Nicolas_upshifts" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="upshifts" CDS 1821024..1821521 /gene="yocC" /locus_tag="BSU_19160" /old_locus_tag="BSU19160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14563871" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389797.1" /db_xref="EnsemblGenomes-Gn:BSU19160" /db_xref="EnsemblGenomes-Tr:CAB13808" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13516" /db_xref="UniProtKB/Swiss-Prot:O35042" /translation="MFTVKEKNRQELEEELNDLEFQIYRMQENMKDLSKDAKVLGIDQ SKHDEWMIVSSIDDGQTCKIMLTDCKTAYRGKGCFSLVASYKDDAIHIGDIKGPPNHG FGSICMKYLKDIARDHNIPKVTGDIAKRDWNHVDRLIHFYEKHHFKVCIDHDTQSGSI KWVDL*" /label="yocC CDS" gene 1821024..1821521 /gene="yocC" /locus_tag="BSU_19160" /old_locus_tag="BSU19160" /label="yocC gene" promotor_-35 1821528..1821531 /Source="Nicolas_upshift_promotors" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="promotor_-35" promotor_-10 1821547..1821566 /Source="Nicolas_upshift_promotors" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="promotor_-10" upshifts 1821549 /Source="Nicolas_upshifts" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="upshifts" CDS 1821585..1822562 /gene="yocD" /locus_tag="BSU_19170" /old_locus_tag="BSU19170" /EC_number="3.4.17.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22516613; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxypeptidase; aminoacid adenylate hydrolase (microcin resistance)" /protein_id="NP_389798.1" /db_xref="EnsemblGenomes-Gn:BSU19170" /db_xref="EnsemblGenomes-Tr:CAB13809" /db_xref="GOA:O35046" /db_xref="InterPro:IPR003507" /db_xref="InterPro:IPR027461" /db_xref="InterPro:IPR027478" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13517" /db_xref="UniProtKB/Swiss-Prot:O35046" /translation="MYASKLKKGDEIRIVSPATSMSILSNEAKIQAKTALERLGYRVT IAEHANECNEFDSSSIESRVHDLHAAFFDPGVKAILTTLGGFNSNQLLRYLDYEKIKR HPKILCGYSDITALCNAIYQKTGLVTYSGPHFSTFAMKKGLDYTEEYFLSCCASDDPF EIHPSSEWSDDRWFLDQENRRFYPNNGPVVIQEGYAEGTLIGGNLCTLNLLQGTEYFP ETEHTILLIEDDYMSDIHMFDRDLQSLIHLPAFSHVKAILIGRFQKASNVSIDLVKAM IETKKELSGIPIIANINAGHTSPIATFPIGGTCRIEAISGTSRIWIDKH*" /label="yocD CDS" gene 1821585..1822562 /gene="yocD" /locus_tag="BSU_19170" /old_locus_tag="BSU19170" /label="yocD gene" downshifts 1822534 /Source="Nicolas_upshifts" /id="D1052" /incds=0 /nref=131 /ntot=256 /MaxReadThrough="3.77491" /MaxDrop="4.2254" /score="1.66373432" /energy="-9.5" /TU="U1558,U1559" /idTUdmin="U1558" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-35 1822659..1822666 /Source="Nicolas_upshift_promotors" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1822681..1822700 /Source="Nicolas_upshift_promotors" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1822688 /Source="Nicolas_upshifts" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="upshifts" CDS 1822724..1823782 /gene="desE" /locus_tag="BSU_19180" /old_locus_tag="BSU19180" /EC_number="1.14.19.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9555904, 11717295, 12207704, 15247225, 15711796, 16105701, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9555904, 11717295, 12207704, 15247225, 15711796, 16105701, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid desaturase" /protein_id="NP_389799.1" /db_xref="EnsemblGenomes-Gn:BSU19180" /db_xref="EnsemblGenomes-Tr:CAB13810" /db_xref="GOA:O34653" /db_xref="InterPro:IPR005804" /db_xref="SubtiList:BG13518" /db_xref="UniProtKB/Swiss-Prot:O34653" /translation="MTEQTIAHKQKQLTKQVAAFAQPETKNSLIQLLNTFIPFFGLWF LAYLSLDVSYLLTLALTVIAAGFLTRIFIIFHDCCHQSFFKQKRYNHILGFLTGVLTL FPYLQWQHSHSIHHATSSNLDKRGTGDIWMLTVNEYKAASRRTKLAYRLYRNPFIMFI LGPIYVFLITNRFNKKGARRKERVNTYLTNLAIVALAAACCLIFGWQSFLLVQGPIFL ISGSIGVWLFYVQHTFEDSYFEADENWSYVQAAVEGSSFYKLPKLLQWLTGNIGYHHV HHLSPKVPNYKLEVAHEHHEPLKNVPTITLKTSLQSLAFRLWDEDNKQFVSFRAIKHI PVSLPPDSPEKQKLRKNA*" /label="desE CDS" gene 1822724..1823782 /gene="desE" /locus_tag="BSU_19180" /old_locus_tag="BSU19180" /label="desE gene" S_feature 1823783..1823852 /Source="Nicolas_S_feature" /locus_tag="new_2090455_2090524" /HighExp="Cold, S8, LoTm, Sw, Paraq, BC, S7, S0, Oxctl, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.859" /TUlongSig="SigA, SigA" /TUlongPSig="0.984, 1" /label="S730" promotor_-35 1823836..1823842 /Source="Nicolas_upshift_promotors" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1823854..1823873 /Source="Nicolas_upshift_promotors" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1823854 /Source="Nicolas_upshifts" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="upshifts" CDS 1823902..1825014 /gene="desK" /locus_tag="BSU_19190" /old_locus_tag="BSU19190" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 23356219, 24574048, 26172072, 28475313" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 23356219, 24574048, 26172072, 28475313; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component thermosensor histidine kinase [DesR-DesK]" /protein_id="NP_389800.1" /db_xref="EnsemblGenomes-Gn:BSU19190" /db_xref="EnsemblGenomes-Tr:CAB13811" /db_xref="GOA:O34757" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="PDB:3EHF" /db_xref="PDB:3EHG" /db_xref="PDB:3EHH" /db_xref="PDB:3EHJ" /db_xref="PDB:3GIE" /db_xref="PDB:3GIF" /db_xref="PDB:3GIG" /db_xref="PDB:5IUJ" /db_xref="PDB:5IUK" /db_xref="PDB:5IUL" /db_xref="PDB:5IUM" /db_xref="PDB:5IUN" /db_xref="SubtiList:BG13519" /db_xref="UniProtKB/Swiss-Prot:O34757" /translation="MIKNHFTFQKLNGITPYIWTIFFILPFYFIWKSSSTFVIIVGII LTLLFFSVYRFAFVSKGWTIYLWGFLLIGISTASITLFSYIYFAFFIAYFIGNIKERV PFHILYYVHLISAAVAANFSLVLKKEFFLTQIPFVVITLISAILLPFSIKSRKERERL EEKLEDANERIAELVKLEERQRIARDLHDTLGQKLSLIGLKSDLARKLIYKDPEQAAR ELKSVQQTARTSLNEVRKIVSSMKGIRLKDELINIKQILEAADIMFIYEEEKWPENIS LLNENILSMCLKEAVTNVVKHSQAKTCRVDIQQLWKEVVITVSDDGTFKGEENSFSKG HGLLGMRERLEFANGSLHIDTENGTKLTMAIPNNSK*" /label="desK CDS" gene 1823902..1825014 /gene="desK" /locus_tag="BSU_19190" /old_locus_tag="BSU19190" /label="desK gene" CDS 1825033..1825632 /gene="desR" /locus_tag="BSU_19200" /old_locus_tag="BSU19200" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 19595746, 20581210, 24574048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 19595746, 20581210, 24574048; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [DesK]" /protein_id="NP_389801.1" /db_xref="EnsemblGenomes-Gn:BSU19200" /db_xref="EnsemblGenomes-Tr:CAB13812" /db_xref="GOA:O34723" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:4LDZ" /db_xref="PDB:4LE0" /db_xref="PDB:4LE1" /db_xref="PDB:4LE2" /db_xref="PDB:5IUJ" /db_xref="PDB:5IUK" /db_xref="PDB:5IUL" /db_xref="PDB:5IUN" /db_xref="SubtiList:BG13520" /db_xref="UniProtKB/Swiss-Prot:O34723" /translation="MISIFIAEDQQMLLGALGSLLNLEDDMEVVGKGTTGQDAVDFVK KRQPDVCIMDIEMPGKTGLEAAEELKDTGCKIIILTTFARPGYFQRAIKAGVKGYLLK DSPSEELANAIRSVMNGKRIYAPELMEDLYSEANPLTDREKEVLELVADGKNTKEIAQ ELSIKSGTVRNYISMILEKLEVKNRIEAITRSKEKGWFK*" /label="desR CDS" gene 1825033..1825632 /gene="desR" /locus_tag="BSU_19200" /old_locus_tag="BSU19200" /label="desR gene" downshifts 1825570 /Source="Nicolas_upshifts" /id="D1053" /incds=1 /nref=1 /ntot=41 /MaxReadThrough="4.44811" /MaxDrop="2.78724" /score="23.648858" /energy="-15.4" /TU="U1560" /idTUdmin="U1560" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 1825614 /Source="Nicolas_upshifts" /id="D1054" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="1.88273" /MaxDrop="3.38398" /score="23.648858" /energy="-15.4" /TU="NA" /idTUdmin="U1560" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1825654..1826152) /Source="Nicolas_S_feature" /locus_tag="new_2092326_2092824_c" /HighExp="S4, LoTm, S6, S3, S5, S8, S7, B36, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.230296" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S731" downshifts complement(1825690) /Source="Nicolas_upshifts" /id="D1055" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="1.62146" /MaxDrop="5.61121" /score="23.7393309" /energy="-12.4" /TU="NA" /idTUdmin="U1563" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1826124..1826133 /Source="Nicolas_upshift_promotors" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1826136..1826154) /Source="Nicolas_upshift_promotors" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1826145..1826339 /Source="Nicolas_S_feature" /locus_tag="new_2092817_2093011" /HighExp="S6, S8, S7, BT, B36, Pyr, G/S, C30, S5, B60" /AntisenseName="yocH" /AntisenseCor="0.113870403460631" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S732" upshifts 1826145 /Source="Nicolas_upshifts" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1826146..1826165 /Source="Nicolas_upshift_promotors" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1826152) /Source="Nicolas_upshifts" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1826171..1826176) /Source="Nicolas_upshift_promotors" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1826227..1827090) /gene="walL" /locus_tag="BSU_19210" /old_locus_tag="BSU19210" /EC_number="3.2.1.-" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:17307850, 20070526, 20487291, 26102633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17307850, 20070526, 20487291, 26102633; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported cell wall lytic enzyme" /protein_id="NP_389802.1" /db_xref="EnsemblGenomes-Gn:BSU19210" /db_xref="EnsemblGenomes-Tr:CAB13813" /db_xref="GOA:O34669" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG13521" /db_xref="UniProtKB/Swiss-Prot:O34669" /translation="MKKTIMSFVAVAALSTTAFGAHASAKEITVQKGDTLWGISQKNG VNLKDLKEWNKLTSDKIIAGEKLTISSEETTTTGQYTIKAGDTLSKIAQKFGTTVNNL KVWNNLSSDMIYAGSTLSVKGQATAANTATENAQTNAPQAAPKQEAVQKEQPKQEAVQ QQPKQETKAEAETSVNTEEKAVQSNTNNQEASKELTVTATAYTANDGGISGVTATGID LNKNPNAKVIAVDPNVIPLGSKVYVEGYGEATAADTGGAIKGNKIDVFVPSKSDASNW GVKTVSVKVLN*" /label="walL CDS" gene complement(1826227..1827090) /gene="walL" /locus_tag="BSU_19210" /old_locus_tag="BSU19210" /label="walL gene" downshifts complement(1826240) /Source="Nicolas_upshifts" /id="D1056" /incds=0 /nref=227 /ntot=262 /MaxReadThrough="2.55593" /MaxDrop="7.59881" /score="23.8272007" /energy="-10.2" /TU="U1565" /idTUdmin="U1565" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts 1826296 /Source="Nicolas_upshifts" /id="D1057" /incds=1 /nref=8 /ntot=28 /MaxReadThrough="6.14664" /MaxDrop="3.95582" /score="23.648858" /energy="-15.4" /TU="U1562" /idTUdmin="U1560" /TUdmin=682 /isTUend="FALSE" /label="downshifts" downshifts complement(1826328) /Source="Nicolas_upshifts" /id="D1058" /incds=1 /nref=10 /ntot=161 /MaxReadThrough="7.34609" /MaxDrop="3.8459" /score="23.8272007" /energy="-10.2" /TU="U1565" /idTUdmin="U1565" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" S_feature 1826341..1827108 /Source="Nicolas_S_feature" /locus_tag="new_2093013_2093780" /HighExp="BT, S8, S6, Gly, S7, C30, G135, G/S, Fru, Pyr" /AntisenseName="yocH" /AntisenseCor="-0.12155468325348801" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S733" promotor_-35 1827086..1827090 /Source="Nicolas_upshift_promotors" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1827099..1827113 /Source="Nicolas_upshift_promotors" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1827110 /Source="Nicolas_upshifts" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1827129..1827148) /Source="Nicolas_upshift_promotors" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1827142) /Source="Nicolas_upshifts" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1827144..1827337) /Source="Nicolas_S_feature" /locus_tag="new_2093816_2094009_c" /HighExp="LoTm, HiOs, S8, C30, S2, G135, G180, T5.0H, S7, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S734" promotor_-35 complement(1827160..1827166) /Source="Nicolas_upshift_promotors" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1827338..1829113) /gene="recQ" /locus_tag="BSU_19220" /old_locus_tag="BSU19220" /EC_number="3.6.1.12" /experiment="publication(s) with functional evidences, PMID:11886746, 16385024, 22200572, 25246477, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 16385024, 22200572, 25246477, 26001966; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent helicase" /protein_id="NP_389803.1" /db_xref="EnsemblGenomes-Gn:BSU19220" /db_xref="EnsemblGenomes-Tr:CAB13814" /db_xref="GOA:O34748" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR002121" /db_xref="InterPro:IPR004589" /db_xref="InterPro:IPR006293" /db_xref="InterPro:IPR010997" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR018982" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032284" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13522" /db_xref="UniProtKB/Swiss-Prot:O34748" /translation="MLHRAQSLLAHYFGYEKFRSGQDEAIRLVTEARQNTACIMPTGG GKSICYQIPALMFEGTTIVISPLISLMKDQVDALEEAGINAAYINSTQSNQEIYERLN GLKEGAYKLFYITPERLTSIEFIRILQGIDVPLVAIDEAHCISQWGHDFRPSYRNIEI LFRELHDKPVIMALTATATPEVHDDICKQLHIQKENTVYTGFSRENLTFKVVKGENKD RFIDEYVQNNRHEAGIVYTATRKEADRIYERLKRNQVRAGRYHGGLADDVRKEQQERF LNDELQVMVATSAFGMGIDKSNIRFVLHAQIPKDMESYYQEAGRAGRDGLASECVLLF SPQDIMVQRFLIEQSEHEEKQKQDLKKLRQMVDYCHTEDCLQRFILMYFGEKEPDACG QCGNCTDTRAAHDVTREAQMVLSCIIRMKERFGKTMVAQVLAGSKNKKVLENGFSDLS TYGILKHQSVGEISDFIEFLISDDFIRMSDGTFPTLFVSSKGRNVLKGELSVARKEAL KAAAITENDELFERLRMVRKEIAAEQGVPPFVVFSDQTLKEMSGKQPVNDDELLSIKG VGEQKRAKYGRLFLQEIQAYARMTD*" /label="recQ CDS" gene complement(1827338..1829113) /gene="recQ" /locus_tag="BSU_19220" /old_locus_tag="BSU19220" /label="recQ gene" S_feature complement(1829114..1829244) /Source="Nicolas_S_feature" /locus_tag="new_2095786_2095916_c" /HighExp="LoTm, G180, Cold, G135, G150, T5.0H, T4.0H, T3.30H, S2, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S735" misc_RNA complement(1829237..1829439) /gene="ssrSA" /locus_tag="BSU_misc_RNA_32" /product="6Sa RNA" /experiment="publication(s) with functional evidences, PMID:11886746, 15793584, 15811922, 22333917, 25576829, 26873600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 15793584, 15811922, 22333917, 25576829, 26873600; Product type n : RNA" /label="ssrSA RNA" gene complement(1829237..1829439) /gene="ssrSA" /locus_tag="BSU_misc_RNA_32" /label="ssrSA gene" downshifts complement(1829289) /Source="Nicolas_upshifts" /id="D1059" /incds=0 /nref=34 /ntot=297 /MaxReadThrough="4.06142" /MaxDrop="7.97725" /score="26.8190437" /energy="-12.7" /TU="U1566" /idTUdmin="U1568" /TUdmin=163 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1829437..1829456) /Source="Nicolas_upshift_promotors" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="promotor_-10" upshifts complement(1829455) /Source="Nicolas_upshifts" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="upshifts" S_feature complement(1829457..1829649) /Source="Nicolas_S_feature" /locus_tag="new_2096129_2096321_c" /HighExp="dia5, Etha, dia15, Diami, S8, S7, C30, G180, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S736" promotor_-35 complement(1829469..1829476) /Source="Nicolas_upshift_promotors" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="promotor_-35" CDS complement(1829678..1830304) /gene="azoJ" /locus_tag="BSU_19230" /old_locus_tag="BSU19230" /EC_number="1.7.-.-" /experiment="publication(s) with functional evidences, PMID:11886746, 18208493, 22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 18208493, 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMN-dependent NADH-azoreductase" /protein_id="NP_389804.1" /db_xref="EnsemblGenomes-Gn:BSU19230" /db_xref="EnsemblGenomes-Tr:CAB13815" /db_xref="GOA:O35022" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR023048" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13523" /db_xref="UniProtKB/Swiss-Prot:O35022" /translation="MSTVLFVKSSDRTAEEGVSTKLYEAFLAAYKENNPNDEVVELDL HKENLPYLGRDMINGTFKAGQGMEMTEDEKKQAAIADKYLNQFVKADKVVFAFPLWNF TVPAVLHTYVDYLSRAGVTFKYTQEGPVGLMGGKKVALLNARGGVYSEGPMAALEMSL NFMKTVLGFWGVQDLHTVVIEGHNAAPDQAQEIVEKGLQEAKDLAAKF*" /label="azoJ CDS" gene complement(1829678..1830304) /gene="azoJ" /locus_tag="BSU_19230" /old_locus_tag="BSU19230" /label="azoJ gene" downshifts complement(1829694) /Source="Nicolas_upshifts" /id="D1060" /incds=0 /nref=68 /ntot=205 /MaxReadThrough="5.10353" /MaxDrop="5.66408" /score="1.15982687" /energy="-10.9" /TU="U1567,U1568" /idTUdmin="U1567" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1830338..1830357) /Source="Nicolas_upshift_promotors" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="promotor_-10" upshifts complement(1830351) /Source="Nicolas_upshifts" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="upshifts" promotor_-35 complement(1830371..1830378) /Source="Nicolas_upshift_promotors" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="promotor_-35" CDS complement(1830455..1830946) /gene="yocK" /locus_tag="BSU_19240" /old_locus_tag="BSU19240" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 15496987, 15496987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative general stress protein" /protein_id="NP_389805.2" /db_xref="EnsemblGenomes-Gn:BSU19240" /db_xref="EnsemblGenomes-Tr:CAB13816" /db_xref="GOA:P80872" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR020458" /db_xref="InterPro:IPR037187" /db_xref="SubtiList:BG13524" /db_xref="UniProtKB/Swiss-Prot:P80872" /translation="MALTKEQTQHLYHKLLDMQKELSGEKKETESMTEEVGELSNGVD NHMADHGTLVTDRMTDQTVKEIDRELLEEVNRALQKMKDGTYGVCEKTGQEIPYERLE AVPYARMTVEAQADVEDDLETDAPSYEREFHEQVKDLSNKETIDQKSSQTYEILDREQ DSK*" /label="yocK CDS" gene complement(1830455..1830946) /gene="yocK" /locus_tag="BSU_19240" /old_locus_tag="BSU19240" /label="yocK gene" downshifts complement(1830464) /Source="Nicolas_upshifts" /id="D1061" /incds=0 /nref=5 /ntot=49 /MaxReadThrough="7.79466" /MaxDrop="4.30433" /score="1.15982687" /energy="-10.9" /TU="U1568,U1573" /idTUdmin="U1571" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1830958..1830976) /Source="Nicolas_upshift_promotors" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="promotor_-10" upshifts complement(1830970) /Source="Nicolas_upshifts" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="upshifts" promotor_-35 complement(1830990..1830996) /Source="Nicolas_upshift_promotors" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="promotor_-35" CDS complement(1831021..1831353) /gene="yocL" /locus_tag="BSU_19250" /old_locus_tag="BSU19250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21926231" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389806.1" /db_xref="EnsemblGenomes-Gn:BSU19250" /db_xref="EnsemblGenomes-Tr:CAB13817" /db_xref="SubtiList:BG13525" /db_xref="UniProtKB/Swiss-Prot:O34976" /translation="MKKMFRSLIRHCLKPELDKLRECEERLSVIEKQKQSSKQESEET YIHIETLNVEKVDYHLEFGELTIDELSGRLNIGATYYIPPEEKDKKCQRKPEAPSTPA VTIRSKRQ*" /label="yocL CDS" gene complement(1831021..1831353) /gene="yocL" /locus_tag="BSU_19250" /old_locus_tag="BSU19250" /label="yocL gene" S_feature complement(1831354..1831644) /Source="Nicolas_S_feature" /locus_tag="new_2098025_2098315_c" /HighExp="Salt, Cold, S3, S8, S4, S7, T5.0H, T3.30H, S6, T4.0H" /AntisenseName="yoyB" /AntisenseCor="0.489341986454357" /AntisenseRegPval="-16.899999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigWXY" /TUshortPSig="0.698, 0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S737" promotor_-35 1831369..1831374 /Source="Nicolas_upshift_promotors" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="promotor_-35" promotor_-10 1831389..1831407 /Source="Nicolas_upshift_promotors" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="promotor_-10" upshifts 1831391 /Source="Nicolas_upshifts" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="upshifts" CDS 1831431..1831658 /gene="yoyB" /locus_tag="BSU_19259" /old_locus_tag="BSU19259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19383706, 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097740.1" /db_xref="EnsemblGenomes-Gn:BSU19259" /db_xref="EnsemblGenomes-Tr:CAX52637" /db_xref="UniProtKB/Swiss-Prot:C0H429" /translation="MLPTNINISHLKTNSIGTGSSLTFGSAELRNRCSAIKRNNGFGE QNADGIVMVIPIESIDDRDVSDALSMKINHQ*" /label="yoyB CDS" gene 1831431..1831658 /gene="yoyB" /locus_tag="BSU_19259" /old_locus_tag="BSU19259" /label="yoyB gene" CDS complement(1831645..1832121) /gene="yocM" /locus_tag="BSU_19260" /old_locus_tag="BSU19260" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11150673, 23155385; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative chaperone" /protein_id="NP_389808.1" /db_xref="EnsemblGenomes-Gn:BSU19260" /db_xref="EnsemblGenomes-Tr:CAB13818" /db_xref="InterPro:IPR002068" /db_xref="InterPro:IPR008978" /db_xref="InterPro:IPR031107" /db_xref="SubtiList:BG13526" /db_xref="UniProtKB/Swiss-Prot:O34321" /translation="MDFEKMKQWMEFAQQMYGGDFWKQVFDEDQKTPFMTNGQSPFPF AQQDQRGKGDASFPSMDIVDTVAEVQFLIYLPGYRKQDVHILSYGDYLVVKGQRFSYF NEQDFRQKEGKYGSFEKKIPLSDHLHGKMNAIFKDGILYITIQKDEGQAKTIVIDD*" /label="yocM CDS" gene complement(1831645..1832121) /gene="yocM" /locus_tag="BSU_19260" /old_locus_tag="BSU19260" /label="yocM gene" S_feature 1831659..1832166 /Source="Nicolas_S_feature" /locus_tag="new_2098330_2098837" /HighExp="S6, S5, S8, S7, S4, B36, BT, S3, T5.0H, LoTm" /AntisenseName="yocM" /AntisenseCor="0.54530996552252997" /AntisenseRegPval="-21.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.877" /TUlongSig="NA" /TUlongPSig="NA" /label="S738" S_feature complement(1832122..1832224) /Source="Nicolas_S_feature" /locus_tag="new_2098793_2098895_c" /HighExp="Cold, Salt, S8, T5.0H, S3, T-0.40H, T0.0H, S4, T4.0H, S6" /AntisenseName="yozN" /AntisenseCor="0.471443110130365" /AntisenseRegPval="-15.6" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigWXY" /TUshortPSig="0.698, 0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S739" promotor_-35 1832139..1832144 /Source="Nicolas_upshift_promotors" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1832159..1832177 /Source="Nicolas_upshift_promotors" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1832168 /Source="Nicolas_upshifts" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="upshifts" CDS 1832188..1832451 /gene="yozN" /locus_tag="BSU_19270" /old_locus_tag="BSU19270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (mother cell in sporulation)" /protein_id="NP_389809.1" /db_xref="EnsemblGenomes-Gn:BSU19270" /db_xref="EnsemblGenomes-Tr:CAB13819" /db_xref="SubtiList:BG13761" /db_xref="UniProtKB/Swiss-Prot:O31846" /translation="MVQPTPYININIFMLKINSFENASAVNVGQNLLAEWQNSDKKNQ GYGQNFGDASGFMGTRSHVDDRDQIDSPASFESEAVNSSIKRK*" /label="yozN CDS" gene 1832188..1832451 /gene="yozN" /locus_tag="BSU_19270" /old_locus_tag="BSU19270" /label="yozN gene" promotor_-10 complement(1832204..1832223) /Source="Nicolas_upshift_promotors" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1832224) /Source="Nicolas_upshifts" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1832226..1832751) /Source="Nicolas_S_feature" /locus_tag="new_2098897_2099422_c" /HighExp="Salt, Cold, T-0.40H, T0.0H, T0.30H, T-1.10H, T-1.40H, T3.30H, T2.0H, S0" /AntisenseName="yocN" /AntisenseCor="-0.51964820699949898" /AntisenseRegPval="-19.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S740" promotor_-35 complement(1832237..1832241) /Source="Nicolas_upshift_promotors" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1832456..1832689 /gene="yocN" /locus_tag="BSU_19280" /old_locus_tag="BSU19280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (sporulation-related)" /protein_id="NP_389810.1" /db_xref="EnsemblGenomes-Gn:BSU19280" /db_xref="EnsemblGenomes-Tr:CAB13820" /db_xref="SubtiList:BG13527" /db_xref="UniProtKB/Swiss-Prot:O34855" /translation="MFFSPSVVNVGGFKINTMDRGSSLTLGPYQQVDYFLSAKINQGF GEENGDFTPLVVPISNVLDADLVDSNSAKNSVV*" /label="yocN CDS" gene 1832456..1832689 /gene="yocN" /locus_tag="BSU_19280" /old_locus_tag="BSU19280" /label="yocN gene" downshifts 1832676 /Source="Nicolas_upshifts" /id="D1062" /incds=0 /nref=62 /ntot=90 /MaxReadThrough="2.0117" /MaxDrop="7.59451" /score="5.68120132" /energy="-10.9" /TU="NA" /idTUdmin="U1570" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1832775..1833119) /gene="yozO" /locus_tag="BSU_19290" /old_locus_tag="BSU19290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23155385" /codon_start=1 /transl_table=11 /product="conserved hypothetical phage protein" /protein_id="NP_389811.1" /db_xref="EnsemblGenomes-Gn:BSU19290" /db_xref="EnsemblGenomes-Tr:CAB13821" /db_xref="InterPro:IPR011993" /db_xref="InterPro:IPR012544" /db_xref="InterPro:IPR037063" /db_xref="SubtiList:BG13762" /db_xref="UniProtKB/Swiss-Prot:O31847" /translation="MGIFSVSRSTDAKKLEALLVEGERIESIYKLRVDQICFTNKRII FFDNKMFSKKKVRVFLPYKTIESFAIQEAGMFDPDTGLLLMTRSKTFELEFAKDTDLS EVQAVLTKHLCS*" /label="yozO CDS" gene complement(1832775..1833119) /gene="yozO" /locus_tag="BSU_19290" /old_locus_tag="BSU19290" /label="yozO gene" downshifts complement(1832796) /Source="Nicolas_upshifts" /id="D1063" /incds=0 /nref=61 /ntot=217 /MaxReadThrough="4.58642" /MaxDrop="4.1868" /score="12.6520239" /energy="-9.6" /TU="U1572,U1573" /idTUdmin="U1574" /TUdmin=616 /isTUend="FALSE" /label="downshifts" S_feature complement(1833120..1833192) /Source="Nicolas_S_feature" /locus_tag="new_2099791_2099863_c" /HighExp="T0.30H, T0.0H, T1.0H, T-0.40H, T1.30H, T-1.10H, Salt, T2.0H, T-1.40H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S741" promotor_-10 complement(1833188..1833207) /Source="Nicolas_upshift_promotors" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1833192) /Source="Nicolas_upshifts" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1833194..1833297) /Source="Nicolas_S_feature" /locus_tag="new_2099865_2099968_c" /HighExp="T0.30H, T0.0H, T-0.40H, T1.0H, T1.30H, Salt, T-1.10H, T2.0H, T-1.40H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S742" promotor_-35 complement(1833221..1833226) /Source="Nicolas_upshift_promotors" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1833284..1833299) /Source="Nicolas_upshift_promotors" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1833297) /Source="Nicolas_upshifts" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1833312..1833321) /Source="Nicolas_upshift_promotors" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1833440) /Source="Nicolas_upshifts" /id="D1064" /incds=0 /nref=117 /ntot=269 /MaxReadThrough="5.5406" /MaxDrop="6.72115" /score="36.7697843" /energy="-10.7" /TU="U1574" /idTUdmin="U1576" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(1833476..1833679) /gene="yozC" /locus_tag="BSU_19300" /old_locus_tag="BSU19300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389812.1" /db_xref="EnsemblGenomes-Gn:BSU19300" /db_xref="EnsemblGenomes-Tr:CAB13822" /db_xref="SubtiList:BG13750" /db_xref="UniProtKB/Swiss-Prot:O31848" /translation="MIHKNWLEKETIKKVKCVQTNAKKYIVNRVLTPGKEYEVKNETE EFLFVVDNTNKVGGYYKEYFEEM*" /label="yozC CDS" gene complement(1833476..1833679) /gene="yozC" /locus_tag="BSU_19300" /old_locus_tag="BSU19300" /label="yozC gene" promotor_-10 complement(1833700..1833719) /Source="Nicolas_upshift_promotors" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1833718) /Source="Nicolas_upshifts" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1833720..1833786) /Source="Nicolas_S_feature" /locus_tag="new_2100391_2100457_c" /HighExp="S7, S8, S6, S5, C30, S4, T4.0H, B60, BC, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.461" /TUlongSig="NA" /TUlongPSig="NA" /label="S743" promotor_-35 complement(1833735..1833742) /Source="Nicolas_upshift_promotors" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1833752..1833759 /Source="Nicolas_upshift_promotors" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="promotor_-35" upshifts 1833771 /Source="Nicolas_upshifts" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="upshifts" misc_feature complement(1833773..1833785) /Source="Nicolas_upshift_promotors" /id="U1576" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.460539460539461" /xcortree=1224 /SigmaFactorBS="atagcacattgattcctggattgaatagcagaaataagctgt gatagttgcttcaaacgtaagcgtatacaaACATTCTATAATAgaaatcaaggcaaaa t" /listShort="S743, yozC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1833773..1833792 /Source="Nicolas_upshift_promotors" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="promotor_-10" S_feature 1833776..1833908 /Source="Nicolas_S_feature" /locus_tag="new_2100447_2100579" /HighExp="BC, M0t90, M9-stat, S2, T2.30H, Sw, Lbstat, M40t90, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.961" /TUlongSig="NA" /TUlongPSig="NA" /label="S744" upshifts complement(1833797) /Source="Nicolas_upshifts" /id="U1576" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.460539460539461" /xcortree=1224 /SigmaFactorBS="atagcacattgattcctggattgaatagcagaaataagctgt gatagttgcttcaaacgtaagcgtatacaaACATTCTATAATAgaaatcaaggcaaaa t" /listShort="S743, yozC" /GFF_Attribute="listLong" /label="upshifts" CDS 1833909..1835396 /gene="dhaS" /locus_tag="BSU_19310" /old_locus_tag="BSU19310" /EC_number="1.2.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17555270, 23874669, 25409630, 26337367, 27797724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17555270, 23874669, 25409630, 26337367, 27797724; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hydroxypropionaldehyde dehydrogenase" /protein_id="NP_389813.1" /db_xref="EnsemblGenomes-Gn:BSU19310" /db_xref="EnsemblGenomes-Tr:CAB13823" /db_xref="GOA:O34660" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12582" /db_xref="UniProtKB/Swiss-Prot:O34660" /translation="MSSLTMQVTKRLETFLQGTKKLYIDGKFVPSASGATFDTPNPAT GETLMTLYEAQAADVDKAVKAARKAFDQGEWRTMSPASRSRLMYKLADLMEEHKTELA QLETLDNGKPINETTNGDIPLAIEHMRYYAGWCTKITGQTIPVSGAYFNYTRHEPVGV VGQIIPWNFPLLMAMWKMGAALATGCTIVLKPAEQTPLSALYLAELIDQAGFPAGVIN IIPGFGEDAGEALTNHEAVDKIAFTGSTEIGKKIMSTAAKSIKRVTLELGGKSPNILL PDANLKKAIPGALNGVMFNQGQVCCAGSRVFIHKDQYDEVVDEMASYAESLRQGAGLH KDTQIGPLVSKEQHERVLSYIQKGKDEGAKAVTGGSCPFEAGYFVAPTVFANVEDEMT IAKEEIFGPVLTAIPYETVDEVIERANHSEYGLAAGLWTENVKQAHYIADRLQAGTVW VNCYNVFDAASPFGGYKQSGLGREMGSYALDNYTEVKSVWVNLED*" /label="dhaS CDS" gene 1833909..1835396 /gene="dhaS" /locus_tag="BSU_19310" /old_locus_tag="BSU19310" /label="dhaS gene" promotor_-10 complement(1834352..1834369) /Source="Nicolas_upshift_promotors" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1834358) /Source="Nicolas_upshifts" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1834382..1834390) /Source="Nicolas_upshift_promotors" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1835382 /Source="Nicolas_upshifts" /id="D1065" /incds=0 /nref=163 /ntot=260 /MaxReadThrough="3.66831" /MaxDrop="7.01026" /score="24.6079855" /energy="-7.1" /TU="U1575" /idTUdmin="U1575" /TUdmin="-1144" /isTUend="FALSE" /label="downshifts" promotor_-35 1835444..1835449 /Source="Nicolas_upshift_promotors" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1835465..1835483 /Source="Nicolas_upshift_promotors" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1835470 /Source="Nicolas_upshifts" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="upshifts" CDS 1835497..1837395 /gene="sqhC" /locus_tag="BSU_19320" /old_locus_tag="BSU19320" /EC_number="4.2.1.137" /EC_number="5.4.99.17" /function="16.13: Shape" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2253626, 18436644, 18630919, 21627333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2253626, 18436644, 18630919, 21627333; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="squalene-hopene cyclase, sporulenol synthase (spore protection)" /protein_id="NP_389814.2" /db_xref="EnsemblGenomes-Gn:BSU19320" /db_xref="EnsemblGenomes-Tr:CAB13824" /db_xref="GOA:Q796C3" /db_xref="InterPro:IPR008930" /db_xref="InterPro:IPR018333" /db_xref="InterPro:IPR032696" /db_xref="InterPro:IPR032697" /db_xref="SubtiList:BG12679" /db_xref="UniProtKB/Swiss-Prot:Q796C3" /translation="MGTLQEKVRRFQKKTITELRDRQNADGSWTFCFEGPIMTNSFFI LLLTSLDEGENEKELISSLAAGIHAKQQPDGTFINYPDETRGNLTATVQGYVGMLASG CFHRTEPHMKKAEQFIISHGGLRHVHFMTKWMLAANGLYPWPALYLPLSLMALPPTLP IHFYQFSSYARIHFAPMAVTLNQRFVLINRNISSLHHLDPHMTKNPFTWLRSDAFEER DLTSILLHWKRVFHAPFAFQQLGLQTAKTYMLDRIEKDGTLYSYASATIYMVYSLLSL GVSRYSPIIRRAITGIKSLVTKCNGIPYLENSTSTVWDTALISYALQKNGVTETDGSV TKAADFLLERQHTKIADWSVKNPNSVPGGWGFSNINTNNPDCDDTTAVLKAIPRNHSP AAWERGVSWLLSMQNNDGGFSAFEKNVNHPLIRLLPLESAEDAAVDPSTADLTGRVLH FLGEKVGFTEKHQHIQRAVKWLFEHQEQNGSWYGRWGVCYIYGTWAALTGMHACGVDR KHPGIQKALRWLKSIQNDDGSWGESCKSAEIKTYVPLHRGTIVQTAWALDALLTYENS EHPSVVKGMQYLTDSSSHSADSLAYPAGIGLPKQFYIRYHSYPYVFSLLAVGKYLDSI EKETANET*" /label="sqhC CDS" gene 1835497..1837395 /gene="sqhC" /locus_tag="BSU_19320" /old_locus_tag="BSU19320" /label="sqhC gene" promotor_-10 complement(1836440..1836459) /Source="Nicolas_upshift_promotors" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1836448) /Source="Nicolas_upshifts" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1836473..1836482) /Source="Nicolas_upshift_promotors" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1837385..1838230 /gene="sodF" /locus_tag="BSU_19330" /old_locus_tag="BSU19330" /EC_number="1.15.1.1" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17114254, 20233928; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="superoxide dismutase (Fe2+-dependent)" /protein_id="NP_389815.1" /db_xref="EnsemblGenomes-Gn:BSU19330" /db_xref="EnsemblGenomes-Tr:CAB13825" /db_xref="GOA:O35023" /db_xref="InterPro:IPR001189" /db_xref="InterPro:IPR019831" /db_xref="InterPro:IPR019832" /db_xref="InterPro:IPR019833" /db_xref="InterPro:IPR036314" /db_xref="InterPro:IPR036324" /db_xref="SubtiList:BG12676" /db_xref="UniProtKB/Swiss-Prot:O35023" /translation="MKRESYQAEMFNWCEALKDQIQKRGQLDQFEDQIDKMIEALEDD QTTEEDWYKQAAALYRDITESDDTSERRAYVPIGKHVLPKLPYKYSALEPYISRDIMI LHHTKHHQSYVDGLNKAESELKKARATKNYDLITHWERELAFHGAGHYLHSIFWFSMH PNGKRRPTGALFQMIDLSFGSYSAFKEHFTQASKKVEGVGWAILVWAPRSGRLEILTA EKHQLFSQWDVIPLLPLDVWEHAYYLQYKNDRASYVDHWWNVVDWREAEKRFEQAKEV VWKLY*" /label="sodF CDS" gene 1837385..1838230 /gene="sodF" /locus_tag="BSU_19330" /old_locus_tag="BSU19330" /label="sodF gene" S_feature 1838231..1839737 /Source="Nicolas_S_feature" /locus_tag="new_2104902_2106408" /HighExp="S5, S6, S4, S8, S3, S7, T5.0H, B36, BT, T4.0H" /AntisenseName="yocR" /AntisenseCor="-0.62866346519731298" /AntisenseRegPval="-30.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S745" CDS complement(1838263..1839600) /gene="yocR" /locus_tag="BSU_19340" /old_locus_tag="BSU19340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254, 27766092; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent transporter" /protein_id="NP_389816.1" /db_xref="EnsemblGenomes-Gn:BSU19340" /db_xref="EnsemblGenomes-Tr:CAB13826" /db_xref="GOA:O34383" /db_xref="InterPro:IPR000175" /db_xref="SubtiList:BG13528" /db_xref="UniProtKB/Swiss-Prot:O34383" /translation="MKEANQWSSKLGFILAAAGSAIGLGAIWKFPYVAGTSGGGAFLL IFILFTVLIGLPLLLGEFIIGRRTQKDAVQSYKTLAPGTKWHWIGYLGMVTCFILLSF YSVVGGWILIYIIKGFTGGLSQTSGFDTIFASTISNPYLAVGGQLLFMVVTILVVAKG VSSGIEKASQVLMPALFLLFIILMVRSVTLDGAMEGIKFFLMPDLTAIDANTILYAMG QSFFLLSVGVSVMVTYSAYLEKQENLVQSAVSVTVMNMLVAVMAGIAIFPAVFSFGLK PDQGPVLLFNVLPTVFNQMPFGIIFLLAFLLLFLFAALTSAFSMLEILVAVLSKGDIN KRKRFAWLGGIAIFIVGVPSALSYGVLSDVTIFHLSIFDAADYLVSNILMPLGALLIS IFVPLKIPKQDLFDELKSGSNLKRKWFAVWLLLIRYLSPVAIIIVFLHVIGIF*" /label="yocR CDS" gene complement(1838263..1839600) /gene="yocR" /locus_tag="BSU_19340" /old_locus_tag="BSU19340" /label="yocR gene" downshifts complement(1838274) /Source="Nicolas_upshifts" /id="D1066" /incds=0 /nref=1 /ntot=50 /MaxReadThrough="0.83968" /MaxDrop="2.44824" /score="27.8372036" /energy="-11.1" /TU="NA" /idTUdmin="U1580" /TUdmin=154 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1839628..1839647) /Source="Nicolas_upshift_promotors" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1839643) /Source="Nicolas_upshifts" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1839645..1840803) /Source="Nicolas_S_feature" /locus_tag="new_2106316_2107474_c" /HighExp="M9-stat, T1.30H, B60, T1.0H, T2.0H, T0.30H, T2.30H, T3.0H, T3.30H, Etha" /AntisenseName="yocS" /AntisenseCor="-6.3575129468026695E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S746" promotor_-35 complement(1839662..1839669) /Source="Nicolas_upshift_promotors" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1839721..1839724 /Source="Nicolas_upshift_promotors" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1839739..1839758 /Source="Nicolas_upshift_promotors" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1839739 /Source="Nicolas_upshifts" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="upshifts" CDS 1839819..1840784 /gene="yocS" /locus_tag="BSU_19350" /old_locus_tag="BSU19350" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 27766092; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent symporter" /protein_id="NP_389817.1" /db_xref="EnsemblGenomes-Gn:BSU19350" /db_xref="EnsemblGenomes-Tr:CAB13827" /db_xref="GOA:O34524" /db_xref="InterPro:IPR002657" /db_xref="InterPro:IPR004710" /db_xref="SubtiList:BG13529" /db_xref="UniProtKB/Swiss-Prot:O34524" /translation="MDIIRKISHFAGQTFGIWVIVFAVLGFSFPSLFTWISSYITIFL GIIMFGMGLTLQADDFKELVRKPWQVIIGVIAQYTIMPLVAFGLAFGLHLPAEIAVGV ILVGCCPGGTASNVMTFLAKGNTALSVAVTTISTLLAPVVTPLLIMLFAKEWLPVSPG SLFISILQAVLFPIIAGLIVKMFFRKQVAKAVHALPLVSVIGIVAIVSAVVSGNRENL LQSGLLIFSVVILHNGIGYLLGFLCAKLLKMDYPSQKAIAIEVGMQNSGLGAALATAH FSPLSAVPSAIFSVWHNLSGSMLATYWSKKVKKKQAGSKSSNLSL*" /label="yocS CDS" gene 1839819..1840784 /gene="yocS" /locus_tag="BSU_19350" /old_locus_tag="BSU19350" /label="yocS gene" downshifts 1840772 /Source="Nicolas_upshifts" /id="D1067" /incds=0 /nref=42 /ntot=166 /MaxReadThrough="3.53218" /MaxDrop="5.09676" /score="30.279305" /energy="-16.4" /TU="U1581" /idTUdmin="U1581" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1840834..1842087) /gene="odhB" /locus_tag="BSU_19360" /old_locus_tag="BSU19360" /EC_number="2.3.1.61" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1508153, 2500417, 22720735, 26098117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1508153, 2500417, 22720735, 26098117; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate dehydrogenase complex (dihydrolipoamide transsuccinylase, E2 subunit)" /protein_id="NP_389818.2" /db_xref="EnsemblGenomes-Gn:BSU19360" /db_xref="EnsemblGenomes-Tr:CAB13828" /db_xref="GOA:P16263" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR006255" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10273" /db_xref="UniProtKB/Swiss-Prot:P16263" /translation="MAEIKVPELAESISEGTIAQWLKQPGDYVEQGEYLLELETDKVN VELTAEESGVLQEVLKDSGDTVQVGEIIGTISEGAGESSAPAPTEKTESKESVKEEKQ AEPAAQEVSEEAQSEAKSRTIASPSARKLAREKGIDLSQVPTGDPLGRVRKQDVEAYE KPASKPAPQQKQQPQAQKAQQSFDKPVEVQKMSRRRQTIAKRLVEVQQTSAMLTTFNE VDMTAVMNLRKRRKDQFFEQNEVKLGFMSFFTKAVVAALKKYPLLNAEIQGDELIVKK FYDIGIAVAADEGLVVPVVRDADRLTFAGIEKEIGELAKKARNNKLTLSELQGGSFTI TNGGTFGSLMSTPILNSPQVGILGMHKIQLRPVAIDEERFENRPMMYIALSYDHRIVD GKEAVGFLVTIKNLLEDPEQLLLEG*" /label="odhB CDS" gene complement(1840834..1842087) /gene="odhB" /locus_tag="BSU_19360" /old_locus_tag="BSU19360" /label="odhB gene" downshifts complement(1840848) /Source="Nicolas_upshifts" /id="D1068" /incds=0 /nref=200 /ntot=253 /MaxReadThrough="5.25481" /MaxDrop="7.42366" /score="11.7726103" /energy="-16.4" /TU="U1582" /idTUdmin="U1582" /TUdmin="-1694" /isTUend="FALSE" /label="downshifts" CDS complement(1842103..1844937) /gene="odhA" /locus_tag="BSU_19370" /old_locus_tag="BSU19370" /EC_number="1.2.4.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1508153, 2500417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1508153, 2500417; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate dehydrogenase (E1 subunit)" /protein_id="NP_389819.3" /db_xref="EnsemblGenomes-Gn:BSU19370" /db_xref="EnsemblGenomes-Tr:CAB13829" /db_xref="GOA:P23129" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR011603" /db_xref="InterPro:IPR023784" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR031717" /db_xref="InterPro:IPR032106" /db_xref="SubtiList:BG10272" /db_xref="UniProtKB/Swiss-Prot:P23129" /translation="MFQNSMKQRMNWEDFYGPNLGYALELYDQYTQDPNSIDPDLKEM FDELGAPPSDIKEASGTKEKGRVTADLIQKIASAVRLAEDIRTYGHLNASVNPLRKDE KKSELFPLSDYGLTEEEIKAIPASVICKDAPKNISNGLEAIQYLRNTYKRTISFEFDH VHDFKEREWLTRKIESGELFQKNSAEKLSAVLERLTEVEGFEQFLHRTFVGQKRFSIE GLDALVPVLDDIIAQSVKSGTTSVNIGMAHRGRLNVLAHVLGKPYEIIFSEFQHAPNK DLVPSEGSIGISYGWTGDVKYHLGANRELQDAETKSARITLANNPSHLEFINPIVEGS TRAAQETRTQSGYPVQDETKSLAILIHGDAAFPGEGIVAETLNLSSLKGYQVGGAIHI IANNMIGFTTESAESRSTKYASDLAKGYEIPIVHVNADDPEACLSAVKFAVEYRKTFN KDFLIDLIGYRRYGHNEMDEPSTTQPMLYDAVRKHPTVKQIFAEKLVKEGVVTEEVVQ NIEKSVTKRIEDAYQKVPSKKEHTACEIELPEPVSNGFPDVDTSIDFDVLRKLNGELI NWPESFNVFGKLKRILERRAKAFDDDRKVEWSLAESLAFASILKDGTPIRLTGQDSER GTFAQRNLVLHDSETGKEFVPLHHLSDCSTSFAVHNSPLSEGSVLGFEYGYNVHSPET LVLWEAQYGDFANAAQVYFDQFISAGRAKWGQKSGLVMLLPHGYEGQGPEHSSGRIER FLQLAAENNWTVANLTSAAQYFHILRRQAKMLLREEIRPLVIMTPKSLLRNPNTVSEV QELSESRFQPVYEQSGLSHDYEKVTRLVLSSGKVSIDISDHFNKLEDGKEWLHIARIE QLYPFPAKGVKELFAKLPNLKEIVWVQEEPQNMGAWGYISPYLTEIAPEGVSVQYIGR RRRSSPAEGDPTVHKKEQERIVSDSLTRKN*" /label="odhA CDS" gene complement(1842103..1844937) /gene="odhA" /locus_tag="BSU_19370" /old_locus_tag="BSU19370" /label="odhA gene" promotor_-10 complement(1845032..1845051) /Source="Nicolas_upshift_promotors" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1845047) /Source="Nicolas_upshifts" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1845049..1845165) /Source="Nicolas_S_feature" /locus_tag="new_2111720_2111836_c" /HighExp="dia15, G150, G135, H2O2, Lbexp, dia0, Oxctl, LBGtran, G180, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S747" promotor_-35 complement(1845066..1845073) /Source="Nicolas_upshift_promotors" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1845166..1847082) /gene="yojO" /locus_tag="BSU_19380" /old_locus_tag="BSU19380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23087684; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative activator of nitric oxide reductase" /protein_id="NP_389820.2" /db_xref="EnsemblGenomes-Gn:BSU19380" /db_xref="EnsemblGenomes-Tr:CAB13830" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG13567" /db_xref="UniProtKB/Swiss-Prot:O31849" /translation="MKFIKFNDSTIDSFLFMMLTDLAKTLTKSEAVEVEYGVQSYYNP FEKKIYMSHFWKDRAAEDMEAGLKSDVYLRSVGTRYSSLHEFANFLNDIHRHLTFKSF AKQLFMLLEDIRIEECIKRERPGTKHVFAKRKDMYRKHFSTQLTLNLERSIFTDALFC AIYFKLTAESPLETLPSMREDIDLMRPFIEQQLLRVYEADSTRQVLKIVEDLMDGLEE VLDKDMLNTYFFLPELDYAKAAEQPLFEEEKKAPKLSDDITLPKQSDGDEDIHEEEMP TWHRETEAPSKSFLQFDIEHGAKSDLGKDASREGDDGDQALGSVQGSARQTKRKDYSK LEALESQKDQPNGAGMADGKENKYAFPIYKEPQPATSEEELSYKQQAKTIESYQKRLK QMIQKTLEHKKTLPRTDLHAGRLNNKLLRYFTERNPRLFYKKQEPSSEIDAVFTLLVD CSASMFDKMDETKRGIVLFHEALKSVAVPHQIVGFWEDTNDATEKSQPNYFNTVIPFQ SSLRQDSGPAIMQLEPEEDNRDGYAIRQMTKKMLHRSEAQKFLIVFSDGEPAAFGYEQ NGIVDTSEAVIEARKRGIEVINVFLSNSEIEESQMKTIQDMYGKFSIFVPDVDQLPDV LYPLLKKLLHKSIG*" /label="yojO CDS" gene complement(1845166..1847082) /gene="yojO" /locus_tag="BSU_19380" /old_locus_tag="BSU19380" /label="yojO gene" CDS complement(1847093..1848007) /gene="yojN" /locus_tag="BSU_19390" /old_locus_tag="BSU19390" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15491156, 23087684; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nitric-oxide reductase associated protein" /protein_id="NP_389821.1" /db_xref="EnsemblGenomes-Gn:BSU19390" /db_xref="EnsemblGenomes-Tr:CAB13831" /db_xref="GOA:O31850" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011704" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13566" /db_xref="UniProtKB/Swiss-Prot:O31850" /translation="MNRKGNLSMTTQLQHLTLPEDIQQKLLSYKEQPISPEFQSLIGT SGYEAEDEAILFDAIIALAMGKNVLLKGPTGSGKTKLAETLSSYFHKPMHSVNCSVDL DAEALVGYKTIENQSGQATIEFVSGPVTKAMKEGHFLYIDEINMAKPETLPILNGVLD YRKMMTNPFTGEVIRAKSGFGVIAAINEGYVGTVPLNEALKNRFVIIDVPYIKGELLK QVLMSQSALKDEKLIDRFITLSSDLIVQANNGQVSEEAASIRALIDTCDLAAYIPPRR AIERGIVEKLDDDREKAAVRNIAETLFE*" /label="yojN CDS" gene complement(1847093..1848007) /gene="yojN" /locus_tag="BSU_19390" /old_locus_tag="BSU19390" /label="yojN gene" promotor_-10 complement(1848011..1848030) /Source="Nicolas_upshift_promotors" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="promotor_-10" upshifts complement(1848026) /Source="Nicolas_upshifts" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="upshifts" promotor_-35 complement(1848047..1848051) /Source="Nicolas_upshift_promotors" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="promotor_-35" CDS complement(1848071..1848661) /gene="sodC" /locus_tag="BSU_19400" /old_locus_tag="BSU19400" /EC_number="1.15.1.1" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15897454" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15897454; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="superoxide dismutase (exported lipoprotein)" /protein_id="NP_389822.1" /db_xref="EnsemblGenomes-Gn:BSU19400" /db_xref="EnsemblGenomes-Tr:CAB13832" /db_xref="GOA:O31851" /db_xref="InterPro:IPR001424" /db_xref="InterPro:IPR024134" /db_xref="InterPro:IPR036423" /db_xref="PDB:1S4I" /db_xref="PDB:1U3N" /db_xref="PDB:1XTL" /db_xref="PDB:1XTM" /db_xref="SubtiList:BG13565" /db_xref="UniProtKB/Swiss-Prot:O31851" /translation="MHRLLLLMMLTALGVAGCGQKKPPDPPNRVPEKKVVETSAFGHH VQLVNREGKAVGFIEIKESDDEGLDIHISANSLRPGASLGFHIYEKGSCVRPDFESAG GPFNPLNKEHGFNNPMGHHAGDLPNLEVGADGKVDVIMNAPDTSLKKGSKLNILDEDG SAFIIHEQADDYLTNPSGNSGARIVCGALLGNNEKQ*" /label="sodC CDS" gene complement(1848071..1848661) /gene="sodC" /locus_tag="BSU_19400" /old_locus_tag="BSU19400" /label="sodC gene" CDS complement(1848754..1849998) /gene="cwlS" /locus_tag="BSU_19410" /old_locus_tag="BSU19410" /EC_number="3.5.1.-" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16855244, 22139507" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16855244, 22139507; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan hydrolase (cell wall-binding d,l-endopeptidase)" /protein_id="NP_389823.1" /db_xref="EnsemblGenomes-Gn:BSU19410" /db_xref="EnsemblGenomes-Tr:CAB13833" /db_xref="GOA:O31852" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13564" /db_xref="UniProtKB/Swiss-Prot:O31852" /translation="MKKKIVAGLAVSAVVGSSMAAAPAEAKTIKVKSGDSLWKLSRQY DTTISALKSENKLKSTVLYVGQSLKVPESSKKSTTSPSNSSKTSTYTVAYGDSLWMIA KNHKMSVSELKSLNSLSSDLIRPGQKLKIKGTSSSSGSNGSKKNSGSNSSGSSKSTYT VKLGDSLWKIANSLNMTVAELKTLNGLTSDTLYPKQVLKIKGSSSPKNGNSGSKKPSN SNPSKTTTYKVKAGDSLWKIANRLGVTVQSIRDKNNLSSDVLQIGQVLTISGASKSNP SNPTKPTKPKDNSGSNIQIGSKIDRMITEAKKYVGVPYRWGGNTPAGFDCSGFIYYLI NNVSSISRLSTAGYWNVMQKVSQPSVGDFVFFTTYKSGPSHMGIYLGGGDFIHASSSG VDISNLSNSYWKQRYLGARSYF*" /label="cwlS CDS" gene complement(1848754..1849998) /gene="cwlS" /locus_tag="BSU_19410" /old_locus_tag="BSU19410" /label="cwlS gene" downshifts complement(1848756) /Source="Nicolas_upshifts" /id="D1069" /incds=0 /nref=20 /ntot=183 /MaxReadThrough="4.09529" /MaxDrop="3.77828" /score="11.0350171" /energy="-4.7" /TU="U1584,U1585" /idTUdmin="U1585" /TUdmin="-616" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1850061..1850079) /Source="Nicolas_upshift_promotors" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1850074) /Source="Nicolas_upshifts" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1850076..1850296) /Source="Nicolas_S_feature" /locus_tag="new_2116747_2116967_c" /HighExp="S2, Lbstat, T2.30H, M0t90, HiOs, T3.0H, Etha, M40t90, T3.30H, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S748" promotor_-35 complement(1850092..1850099) /Source="Nicolas_upshift_promotors" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1850282..1850300) /Source="Nicolas_upshift_promotors" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1850296) /Source="Nicolas_upshifts" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1850312..1850320) /Source="Nicolas_upshift_promotors" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1850380..1851597) /gene="yojK" /locus_tag="BSU_19420" /old_locus_tag="BSU19420" /EC_number="2.4.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative YDP-glycosyltransferase" /protein_id="NP_389824.2" /db_xref="EnsemblGenomes-Gn:BSU19420" /db_xref="EnsemblGenomes-Tr:CAB13834" /db_xref="GOA:O31853" /db_xref="InterPro:IPR002213" /db_xref="InterPro:IPR006326" /db_xref="SubtiList:BG13563" /db_xref="UniProtKB/Swiss-Prot:O31853" /translation="MANVLMIGFPGEGHINPSIGVMKELKSRGENITYYAVKEYKEKI TALDIEFREYHDFRGDYFGKNATGDEERDFTEMLCAFLKACKDIATHIYEEVKHESYD YVIYDHHLLAGKVIANMLKLPRFSLCTTFAMNEEFAKEMMGAYMKGSLEDSPHYESYQ QLAETLNADFQAEIKKPFDVFLADGDLTIVFTSRGFQPLAEQFGERYVFVGPSITERA GNNDFPFDQIDNENVLFISMGTIFNNQKQFFNQCLEVCKDFDGKVVLSIGKHIKTSEL NDIPENFIVRPYVPQLEILKRASLFVTHGGMNSTSEGLYFETPLVVIPMGGDQFVVAD QVEKVGAGKVIKKEELSESLLKETIQEVMNNRSYAEKAKEIGQSLKAAGGSKKAADSI LEAVKQKTQSANA*" /label="yojK CDS" gene complement(1850380..1851597) /gene="yojK" /locus_tag="BSU_19420" /old_locus_tag="BSU19420" /label="yojK gene" downshifts complement(1850406) /Source="Nicolas_upshifts" /id="D1070" /incds=0 /nref=14 /ntot=145 /MaxReadThrough="1.49168" /MaxDrop="4.07727" /score="9.41396656" /energy="-14.4" /TU="NA" /idTUdmin="U1586" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1851630..1851649) /Source="Nicolas_upshift_promotors" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1851638) /Source="Nicolas_upshifts" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1851663..1851670) /Source="Nicolas_upshift_promotors" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1851833..1852456) /gene="cdaS" /locus_tag="BSU_19430" /old_locus_tag="BSU19430" /EC_number="2.7.7.85" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:21566650, 23192352, 24939848, 27252699, 27790204, 28751888" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21566650, 23192352, 24939848, 27252699, 27790204, 28751888; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="spore diadenylate cyclase" /protein_id="NP_389825.3" /db_xref="EnsemblGenomes-Gn:BSU19430" /db_xref="EnsemblGenomes-Tr:CAB13835" /db_xref="GOA:O31854" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR014046" /db_xref="InterPro:IPR019457" /db_xref="InterPro:IPR034693" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG13562" /db_xref="UniProtKB/Swiss-Prot:O31854" /translation="MKAMRYEQISENAFKGKIQVYLEQILGDASLILKTLHEKDQCLL CELDDLGHVFQDMQGIASSFYLQSYIEEFTPAFIELAKAIKALSEHKHGALIVIERAD PVERFIQKGTSLHAEISSSLIESIFFPGNPLHDGALLVRENKLVSAANVLPLTTKEVD IHLGTRHRAALGMSGYTDALVLVVSEETGKMSFAKDGVLYPLISPRT*" /label="cdaS CDS" gene complement(1851833..1852456) /gene="cdaS" /locus_tag="BSU_19430" /old_locus_tag="BSU19430" /label="cdaS gene" S_feature complement(1852457..1852607) /Source="Nicolas_S_feature" /locus_tag="new_2119128_2119278_c" /HighExp="S8, S5, S7, S6, Etha, S4, M9-stat, S3, C30, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S749" promotor_-35 1852483..1852489 /Source="Nicolas_upshift_promotors" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1852495 /Source="Nicolas_upshifts" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1852503..1852514 /Source="Nicolas_upshift_promotors" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1852521..1852529 /Source="Nicolas_upshift_promotors" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 1852537..1852637 /Source="Nicolas_upshift_promotors" /id="U1589" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.56043956043956" /psig="0.006993006993007" /xcortree=1480 /SigmaFactorBS="tggaaatcgaaagaatcattcagtatatttgcacctttttag gcgtgatttcgctttcttttatttatgcccaaatgtttagaaaaacgaaaccgacaaa a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 1852541..1852559 /Source="Nicolas_upshift_promotors" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1852552 /Source="Nicolas_upshifts" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1852590..1852608) /Source="Nicolas_upshift_promotors" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1852597..1852682 /Source="Nicolas_S_feature" /locus_tag="new_2119268_2119353" /HighExp="S8, S7, S4, S5, S6, BT, S3, T5.0H, S2, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigGF" /TUshortPSig="0.00699, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S750" upshifts 1852597 /Source="Nicolas_upshifts" /id="U1589" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.56043956043956" /psig="0.006993006993007" /xcortree=1480 /SigmaFactorBS="tggaaatcgaaagaatcattcagtatatttgcacctttttag gcgtgatttcgctttcttttatttatgcccaaatgtttagaaaaacgaaaccgacaaa a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1852607) /Source="Nicolas_upshifts" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1852624..1852630) /Source="Nicolas_upshift_promotors" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1852658..1852665 /Source="Nicolas_upshift_promotors" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1852678..1852697 /Source="Nicolas_upshift_promotors" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1852684 /Source="Nicolas_upshifts" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="upshifts" CDS 1852722..1854080 /gene="mdtK" /locus_tag="BSU_19440" /old_locus_tag="BSU19440" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14766544, 15849754, 15855508, 16850406, 16954325, 17114254; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Na+-driven efflux MatE family protein" /protein_id="NP_389826.1" /db_xref="EnsemblGenomes-Gn:BSU19440" /db_xref="EnsemblGenomes-Tr:CAB13836" /db_xref="GOA:O31855" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG13561" /db_xref="UniProtKB/Swiss-Prot:O31855" /translation="MKETQNAREKIKQLLHILIPIFITQAGLSLITFLDTVMSGKVSP ADLAGVAIGSSLWTPVYTGLAGILMAVTPIVAQLLGAEKKQKIPFTVLQAVYVAALLS IAVLVIGYAAVDLILGRLNLDIHVHQIAKHFLGFLSLGIFPLFVYTVLRSFIDSLGKT RVTMMITLSSLPINFVLNYVFIFGKFGMPALGGVGAGLASALTYWCICIISFFIIHKN APFSEYGIFLTMYKFSWKACKNLLKIGLPIGFAVFFETSIFAAVTLLMSHFHTVTIAS HQAAMNFASLLYMLPLSVSMALTIVVGFEAGAARFKDARSYSLIGIMMAIGFSLFTAA CILLFREQIAGMYTSDPDVLRLTQHFLIYALFFQLSDAVAAPIQGALRGYKDVNYTLA AAFVSYWVIGLPVGYMVGTFTSLGAFGYWIGLIAGLAAGAVGLFFRLAKLQKRYSQKQ HI*" /label="mdtK CDS" gene 1852722..1854080 /gene="mdtK" /locus_tag="BSU_19440" /old_locus_tag="BSU19440" /label="mdtK gene" promotor_-10 complement(1853064..1853075) /Source="Nicolas_upshift_promotors" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1853069) /Source="Nicolas_upshifts" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1853089..1853095) /Source="Nicolas_upshift_promotors" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1854096..1854944 /gene="rsbRC" /locus_tag="BSU_19450" /old_locus_tag="BSU19450" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 17158665, 20935101, 22287516, 24599254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 17158665, 20935101, 22287516, 24599254; Product type f : factor" /codon_start=1 /transl_table=11 /product="co-antagonist of RsbT; component of the anxiosome (stressosome)" /protein_id="NP_389827.1" /db_xref="EnsemblGenomes-Gn:BSU19450" /db_xref="EnsemblGenomes-Tr:CAB13837" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG13560" /db_xref="UniProtKB/Swiss-Prot:O31856" /translation="MAKNKKLFEYLSQHAETISSTWYETIEETDPNSIYASTDPVVIH NLKSQNLAFNYKINRIFIDDEDVYLPILKEWAFEVTQDQEHLKTPIHYIIREFVRVRD LYVSYVKEFVHLNQNTVKSEEAEDLYHALIKAFDLVIHIFIEEMYKNTSLQLQAQKDM ITELSAPVIVLFHSVGLLPLIGDIDTVRAKLIMENTLHQCAKKKVTQLYIDLSGVAVI DTMVAHQLFSLIEALRLIGVSSTLSGIRPEIAQTAVQLGLSFEGISLRSTLASAIASD LKLKKV*" /label="rsbRC CDS" gene 1854096..1854944 /gene="rsbRC" /locus_tag="BSU_19450" /old_locus_tag="BSU19450" /label="rsbRC gene" promotor_-10 complement(1854360..1854379) /Source="Nicolas_upshift_promotors" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1854367) /Source="Nicolas_upshifts" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1854393..1854401) /Source="Nicolas_upshift_promotors" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1854907 /Source="Nicolas_upshifts" /id="D1071" /incds=0 /nref=10 /ntot=138 /MaxReadThrough="1.62054" /MaxDrop="3.13267" /score="12.3887642" /energy="-14" /TU="NA" /idTUdmin="U1591" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1854939) /Source="Nicolas_upshifts" /id="D1072" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="1.55562" /MaxDrop="4.60101" /score="23.8391861" /energy="-13.7" /TU="NA" /idTUdmin="U1594" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(1854970..1855635) /gene="bshBB" /locus_tag="BSU_19460" /old_locus_tag="BSU19460" /EC_number="3.5.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15136574, 20308541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15136574, 20308541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate N-acetylglucosamine deacetylase (second enzyme)" /protein_id="YP_054582.2" /db_xref="EnsemblGenomes-Gn:BSU19460" /db_xref="EnsemblGenomes-Tr:CAB13838" /db_xref="GOA:O31857" /db_xref="InterPro:IPR003737" /db_xref="InterPro:IPR023841" /db_xref="InterPro:IPR024078" /db_xref="SubtiList:BG13559" /db_xref="UniProtKB/Swiss-Prot:O31857" /translation="MKEHVLVILPHPDDESYGVAGLIALNRKKDIPVTYACATLGEMG RNMGDPFFANRETLPLLRKQELINACKEMDINDLRMLGLRDKTLEFEDDEYLADIMEE IIDDVKPSLIVTFYPGHGVHPDHDACGEAVIRALYRKKKEDRPRTICMAITRNREEVL GEADVVLDIKEVADIKMNALRAHRTQTEGMLRELEEKLKNNEPVMATWFEEEIYWTYQ WND*" /label="bshBB CDS" gene complement(1854970..1855635) /gene="bshBB" /locus_tag="BSU_19460" /old_locus_tag="BSU19460" /label="bshBB gene" downshifts complement(1854984) /Source="Nicolas_upshifts" /id="D1073" /incds=0 /nref=189 /ntot=251 /MaxReadThrough="3.68743" /MaxDrop="7.13247" /score="23.8391861" /energy="-13.7" /TU="U1594" /idTUdmin="U1596" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1855654..1856004) /gene="yojF" /locus_tag="BSU_19470" /old_locus_tag="BSU19470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20308541" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (bacillithiol synthesis operon)" /protein_id="NP_389829.1" /db_xref="EnsemblGenomes-Gn:BSU19470" /db_xref="EnsemblGenomes-Tr:CAB13839" /db_xref="InterPro:IPR014934" /db_xref="InterPro:IPR036492" /db_xref="PDB:1NJH" /db_xref="SubtiList:BG13558" /db_xref="UniProtKB/Swiss-Prot:O31858" /translation="MKAIIKEDVQASLERYADRPVYIHLETTTGSYSAHLNEKNMTVV AYIRNAKVTYHQAKIKGNGPYRVGLKTEEGWIYAEGLTEYTVDEENRLLMAGHLPGGK LAISLQISEKPFTV*" /label="yojF CDS" gene complement(1855654..1856004) /gene="yojF" /locus_tag="BSU_19470" /old_locus_tag="BSU19470" /label="yojF gene" CDS complement(1856001..1856279) /gene="yoyC" /locus_tag="BSU_19479" /old_locus_tag="BSU19479" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20308541, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097741.1" /db_xref="EnsemblGenomes-Gn:BSU19479" /db_xref="EnsemblGenomes-Tr:CAX52638" /db_xref="UniProtKB/Swiss-Prot:O68260" /translation="MDNDKEIVKAYASLWNNRSLAHDDAEAVAEAIDLELLDKRTHPR LRKPMLEKYFAAIQRIVNSQLEPAVKYQLVKLHTERAEYLKEERGEQS*" /label="yoyC CDS" gene complement(1856001..1856279) /gene="yoyC" /locus_tag="BSU_19479" /old_locus_tag="BSU19479" /label="yoyC gene" promotor_-10 complement(1856306..1856325) /Source="Nicolas_upshift_promotors" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1856322) /Source="Nicolas_upshifts" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1856340..1856346) /Source="Nicolas_upshift_promotors" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1856355..1857251) /gene="yojE" /locus_tag="BSU_19480" /old_locus_tag="BSU19480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636, 23944997; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative N-acetylated toxic metabolites" /protein_id="NP_389830.2" /db_xref="EnsemblGenomes-Gn:BSU19480" /db_xref="EnsemblGenomes-Tr:CAB13840" /db_xref="GOA:O31859" /db_xref="InterPro:IPR000620" /db_xref="InterPro:IPR004626" /db_xref="SubtiList:BG13557" /db_xref="UniProtKB/Swiss-Prot:O31859" /translation="MQHAETKKGVIYTAVSFIMWGLFPLYWKLLEQLPALDILAHRII WSFVFMCIVLFFLRQWKIGWQELRSLKKNGGILSLFLASILISINWFVYIWAVNHGFL LEASLGYYINPLVSVLLGILFLKEKLNRLQLVAVSIAAAGVIISAFQYGSIPYVALLL AFSFGLYGLSKKRTSLPSAIGLTLETFMIMPIALGYLLFSGHVQPAGAESGGTWLLLF LAGVFTALPLLLFAEGAKRLPLYQVGILQYIAPTITLLIGLFVYHEPFSSSKAFTFSC IWAALLLFTFSQVKWKRASKSH*" /label="yojE CDS" gene complement(1856355..1857251) /gene="yojE" /locus_tag="BSU_19480" /old_locus_tag="BSU19480" /label="yojE gene" promotor_-35 1857093..1857102 /Source="Nicolas_upshift_promotors" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1857113 /Source="Nicolas_upshifts" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1857116..1857135 /Source="Nicolas_upshift_promotors" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1857131..1857349 /Source="Nicolas_S_feature" /locus_tag="new_2123802_2124020" /HighExp="S6, S8, S7, BT, S5, B36, G/S, Pyr, B60, SMMPr" /AntisenseName="yojE" /AntisenseCor="-0.562105310907978" /AntisenseRegPval="-23.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S751" promotor_-10 complement(1857275..1857294) /Source="Nicolas_upshift_promotors" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1857295) /Source="Nicolas_upshifts" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1857306..1857313) /Source="Nicolas_upshift_promotors" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1857350..1857823 /gene="gerT" /locus_tag="BSU_19490" /old_locus_tag="BSU19490" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17720779" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17720779; Product type s: structure" /codon_start=1 /transl_table=11 /product="component of the spore coat" /protein_id="YP_054583.1" /db_xref="EnsemblGenomes-Gn:BSU19490" /db_xref="EnsemblGenomes-Tr:CAE01457" /db_xref="GOA:Q7WY67" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG14190" /db_xref="UniProtKB/Swiss-Prot:Q7WY67" /translation="MFEWNKYFPFHNQFSKEALKKADPKEVETYVNRVMESVFGSDYA AQFPFRDPLPQKEHPAKPDAKPDVKPDIDIFETADHVFVKVPISEEWLEQVRIKHTSH ELWLENLPRADHPKKVNLPCLVKRKGTKAVYKDGLLEVMFQKQQDYNMSEVEIIR*" /label="gerT CDS" gene 1857350..1857823 /gene="gerT" /locus_tag="BSU_19490" /old_locus_tag="BSU19490" /label="gerT gene" downshifts 1857820 /Source="Nicolas_upshifts" /id="D1074" /incds=0 /nref=23 /ntot=53 /MaxReadThrough="-0.0703700000000005" /MaxDrop="9.27889" /score="40.8456275" /energy="-16.6" /TU="NA" /idTUdmin="U1595" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1857858..1858094) /gene="yojB" /locus_tag="BSU_19510" /old_locus_tag="BSU19510" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389832.1" /db_xref="EnsemblGenomes-Gn:BSU19510" /db_xref="EnsemblGenomes-Tr:CAB13842" /db_xref="GOA:O31861" /db_xref="SubtiList:BG13555" /db_xref="UniProtKB/Swiss-Prot:O31861" /translation="MYPHHSYLRGIPGPAGYPARSPFLFGAPLVGGLLGGFLGSALFN YSRPYAYPPGPYGYGGGPYGFGAGVPYGGYPGFY*" /label="yojB CDS" gene complement(1857858..1858094) /gene="yojB" /locus_tag="BSU_19510" /old_locus_tag="BSU19510" /label="yojB gene" downshifts complement(1857866) /Source="Nicolas_upshifts" /id="D1075" /incds=0 /nref=37 /ntot=68 /MaxReadThrough="2.10188" /MaxDrop="7.8003" /score="35.4403926" /energy="-16.6" /TU="NA" /idTUdmin="U1597" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1858117..1858136) /Source="Nicolas_upshift_promotors" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1858132) /Source="Nicolas_upshifts" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1858150..1858159) /Source="Nicolas_upshift_promotors" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1858179..1859513) /gene="yojA" /locus_tag="BSU_19520" /old_locus_tag="BSU19520" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 3020045, 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative H+/anion permease" /protein_id="NP_389833.1" /db_xref="EnsemblGenomes-Gn:BSU19520" /db_xref="EnsemblGenomes-Tr:CAB13843" /db_xref="GOA:O31862" /db_xref="InterPro:IPR003474" /db_xref="SubtiList:BG13554" /db_xref="UniProtKB/Swiss-Prot:O31862" /translation="MPILIVAVGVLILLFLIIKVKLNTFVSLIVVSFLVAIGLGMDIN KIVLSIETGIGGQLGHLALVFGLGAMLGRLVSDAGGGYRIAITLIDKFGRKRIQAAVV VASFIIGIALFFEVGLVLLIPIVYAIAKELKMPFLYLGIPMAAALNVTHGFLPPHPAP TAISVAYGAHIGQVLLFGIIIAVPTTVIAGPLFNKFAMKRFPGAYQKHGNLSGLGPRK EFQLDETPGFAISAVTSLFPVIFMAMATIFSLLLSEHSKGKDIIEFIGTPGTAMLISL LLALYTMGYARKISMQEIGRSISESISQIAMMLLIIGGGGAFKQVLIDGGVGDYVADF FRQTNMSPLFVAWTIAAVLRLCLGSATVAALTTAGMAAPLMEAGSVNPALMVLATGAG SVIACHVNDAGFWMVKEFFGLSMKETFQTWTLLTTVLSVTGLGCVLLAGLVM*" /label="yojA CDS" gene complement(1858179..1859513) /gene="yojA" /locus_tag="BSU_19520" /old_locus_tag="BSU19520" /label="yojA gene" S_feature complement(1859514..1859649) /Source="Nicolas_S_feature" /locus_tag="new_2126185_2126320_c" /HighExp="M0t90, M40t90, Lbtran, S1, dia5, Mt0, T0.0H, BI, Lbstat, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25781100000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S752" promotor_-10 complement(1859646..1859665) /Source="Nicolas_upshift_promotors" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1859656) /Source="Nicolas_upshifts" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1859680..1859687) /Source="Nicolas_upshift_promotors" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1859745..1859752 /Source="Nicolas_upshift_promotors" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1859767..1859786 /Source="Nicolas_upshift_promotors" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1859770 /Source="Nicolas_upshifts" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1859771..1859877 /Source="Nicolas_S_feature" /locus_tag="new_2126442_2126548" /HighExp="M0t90, M40t90, LoTm, Salt, Cold, BI, HPh, LBGstat, GM 60, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S753" CDS 1859878..1860267 /gene="yodA" /locus_tag="BSU_19530" /old_locus_tag="BSU19530" /EC_number="5.3.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tautomerase" /protein_id="NP_389834.1" /db_xref="EnsemblGenomes-Gn:BSU19530" /db_xref="EnsemblGenomes-Tr:CAB13844" /db_xref="GOA:O34882" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="SubtiList:BG13530" /db_xref="UniProtKB/Swiss-Prot:O34882" /translation="MPLLRFDVIEGRDEKSLQLLLDTAHQAMVEAFGVPERDRYQIVH QHPANELIIQDAGLGFQRTKDMVIISMTSKARTESQKEKLYALLAERLEKKCEISPDD LMVSITENGDADWSFGLGEAQFLNGKL*" /label="yodA CDS" gene 1859878..1860267 /gene="yodA" /locus_tag="BSU_19530" /old_locus_tag="BSU19530" /label="yodA gene" downshifts 1860277 /Source="Nicolas_upshifts" /id="D1076" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="1.20831" /MaxDrop="2.65754" /score="14.4455719" /energy="-13.2" /TU="NA" /idTUdmin="U1599" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1860674..1861012) /gene="arxR" /locus_tag="BSU_19540" /old_locus_tag="BSU19540" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17158660, 18208493, 20652907, 27531959" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17158660, 18208493, 20652907, 27531959; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor" /protein_id="NP_389835.1" /db_xref="EnsemblGenomes-Gn:BSU19540" /db_xref="EnsemblGenomes-Tr:CAB13845" /db_xref="GOA:O34844" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:5HS7" /db_xref="PDB:5HS8" /db_xref="PDB:5HS9" /db_xref="SubtiList:BG13531" /db_xref="UniProtKB/Swiss-Prot:O34844" /translation="MGNTMCPKMESAFSLLGKRWNGLIIHVLMDGPKRFKEITETIPM ISQKMLAERLKELEQNEIVERQVLPETPVKVIYTLTEKGTALQAVFQEMQAWADQFCE PGDTVCEEEK*" /label="arxR CDS" gene complement(1860674..1861012) /gene="arxR" /locus_tag="BSU_19540" /old_locus_tag="BSU19540" /label="arxR gene" promotor_-35 1861035..1861042 /Source="Nicolas_upshift_promotors" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1861056..1861075 /Source="Nicolas_upshift_promotors" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1861065 /Source="Nicolas_upshifts" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="upshifts" S_feature 1861069..1861141 /Source="Nicolas_S_feature" /locus_tag="new_2127740_2127812" /HighExp="dia5, Diami, dia15, Salt, Lbtran, Heat, HiOs, S1, aero, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S754" promotor_-10 complement(1861100..1861119) /Source="Nicolas_upshift_promotors" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1861103) /Source="Nicolas_upshifts" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1861131..1861137) /Source="Nicolas_upshift_promotors" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1861142..1861750 /gene="noxC" /locus_tag="BSU_19550" /old_locus_tag="BSU19550" /EC_number="1.6.99.3" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 21749987, 24525333, 26312069; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="water forming NADH oxidase (nitroreductase)" /protein_id="NP_389836.1" /db_xref="EnsemblGenomes-Gn:BSU19550" /db_xref="EnsemblGenomes-Tr:CAB13846" /db_xref="GOA:P81102" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="SubtiList:BG13532" /db_xref="UniProtKB/Swiss-Prot:P81102" /translation="MTNTLDVLKARASVKEYDTNAPISKEELTELLDLATKAPSAWNL QHWHFTVFHSDESKAELLPVAYNQKQIVESSAVVAILGDLKANENGEEVYAELASQGY ITDEIKQTLLGQINGAYQSEQFARDSAFLNASLAAMQLMIAAKAKGYDTCAIGGFNKE QFQKQFDISERYVPVMLISIGKAVKPAHQSNRLPLSKVSTWL*" /label="noxC CDS" gene 1861142..1861750 /gene="noxC" /locus_tag="BSU_19550" /old_locus_tag="BSU19550" /label="noxC gene" downshifts 1861740 /Source="Nicolas_upshifts" /id="D1077" /incds=0 /nref=98 /ntot=245 /MaxReadThrough="1.58009" /MaxDrop="5.56809" /score="28.8840715" /energy="-14.3" /TU="NA" /idTUdmin="U1600" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(1861793..1862395) /gene="yodD" /locus_tag="BSU_19560" /old_locus_tag="BSU19560" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389837.1" /db_xref="EnsemblGenomes-Gn:BSU19560" /db_xref="EnsemblGenomes-Tr:CAB13847" /db_xref="GOA:O34842" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13533" /db_xref="UniProtKB/Swiss-Prot:O34842" /translation="MKHIYEKGTSDNVLLLLHGTGGNEHDLLSLGRFIDPDAHLLGVR GSVLENGMPRFFKRLSEGVFDEKDLVVRTRELKDFIDEAAETHQFNRGRVIAVGYSNG ANIAASLLFHYKDVLKGAILHHPMVPIRGIELPDMAGLPVFIGAGKYDPLCTKEESEE LYRYLRDSGASASVYWQDGGHQLTQHEAEQAREWYKEAIV*" /label="yodD CDS" gene complement(1861793..1862395) /gene="yodD" /locus_tag="BSU_19560" /old_locus_tag="BSU19560" /label="yodD gene" CDS complement(1862411..1863322) /gene="yodE" /locus_tag="BSU_19570" /old_locus_tag="BSU19570" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 17407181, 19329649, 25720121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-dependent lyase/dioxygenase" /protein_id="NP_389838.1" /db_xref="EnsemblGenomes-Gn:BSU19570" /db_xref="EnsemblGenomes-Tr:CAB13848" /db_xref="GOA:O34543" /db_xref="InterPro:IPR000595" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13534" /db_xref="UniProtKB/Swiss-Prot:O34543" /translation="MKTEGLHHVTAFARDPQENLRFYTEVLGLRLVKKTVNFDDPGTY HFYFGNQNGDPGTIMTFFPFQGSGQGTVGKGQAGRVYFSVPSGSLSFWKERLEKSGLS LEEKTLFGEKGLIFDDTEDLPLAIMEDAKSGKSEWTPDGITTNEAITGMKGVLLYSYD PQATIQLLTESFGYTKVAEEDQIVRLASSAAVGGVIDVHLHPEKRGVGGYGTVHHVAF RTKKKEQAKWLPIIAENHLPSSEILDREYFTSVYFREKGGILFEIATDEPGFMTDETF AELGTSLKLPEWLEKHRQQITDILPEL*" /label="yodE CDS" gene complement(1862411..1863322) /gene="yodE" /locus_tag="BSU_19570" /old_locus_tag="BSU19570" /label="yodE gene" promotor_-10 complement(1863351..1863370) /Source="Nicolas_upshift_promotors" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1863367) /Source="Nicolas_upshifts" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1863386..1863391) /Source="Nicolas_upshift_promotors" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1863443..1863446 /Source="Nicolas_upshift_promotors" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1863461..1863480 /Source="Nicolas_upshift_promotors" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1863463 /Source="Nicolas_upshifts" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="upshifts" CDS 1863506..1863706 /gene="yoyD" /locus_tag="BSU_19579" /old_locus_tag="BSU19579" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23504016, 24843172; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="YP_003097742.1" /db_xref="EnsemblGenomes-Gn:BSU19579" /db_xref="EnsemblGenomes-Tr:CAX52639" /db_xref="GOA:C0H431" /db_xref="InterPro:IPR021741" /db_xref="UniProtKB/Swiss-Prot:C0H431" /translation="MVKKALIVILILLPFVQLALLPLVNRIEPIMFGLPFFHFWLLLW IIVTPLCSFGIYQMQKKDGGLE*" /label="yoyD CDS" gene 1863506..1863706 /gene="yoyD" /locus_tag="BSU_19579" /old_locus_tag="BSU19579" /label="yoyD gene" CDS 1863706..1865196 /gene="yodF" /locus_tag="BSU_19580" /old_locus_tag="BSU19580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12823818, 15849754, 16850406, 24142252, 27766092; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative Na+/metabolite permease" /protein_id="NP_389839.1" /db_xref="EnsemblGenomes-Gn:BSU19580" /db_xref="EnsemblGenomes-Tr:CAB13849" /db_xref="GOA:O34745" /db_xref="InterPro:IPR001734" /db_xref="SubtiList:BG13535" /db_xref="UniProtKB/Swiss-Prot:O34745" /translation="MQGNLTALLITAIIVLTVVCIGFLAGRDKSSRTSVEEWSVGGRR FGGLLVWFLVGADLYTAYTFLGLTSTAFTGGSVAFFAIPYSVLAYFIAYFFLPKLWKV AKIHKLTTLADYARERFNSKLLASLVAIVGVLMLIPYICLQLSGIQDTLQVAGTGYIN VKFVVIISFILVALYTFFSGIKGPTYTAIIKDILVWVIMLFMVVSLPLIHFNGWTPMI DTLVKEAPQMLTIPSEGPKGIPWFITASIVSALALFMWAHAATGVFTAKSADAVRKNS MFLPLYNIVLILVIFLGFIAFLVLPEDTNPRLALLHLIQTSYGGVAQGFAYATIALAS LIPCSIMAIGASNLFANNLYRDLIHPNVSQSKLTLVTRSMVFVVIGLALLFGMLFPTA LVTLQLLGVSGMVQIFPAIAVSLFWKNQTKEATVIGLLAGLAVTFIVYITQSAHGIYE GFWGLAANMIAVVILNPLFVKNAGSNPVIEGLFGKKQDANPNQKGA*" /label="yodF CDS" gene 1863706..1865196 /gene="yodF" /locus_tag="BSU_19580" /old_locus_tag="BSU19580" /label="yodF gene" promotor_-10 complement(1864441..1864452) /Source="Nicolas_upshift_promotors" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1864445) /Source="Nicolas_upshifts" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1864466..1864472) /Source="Nicolas_upshift_promotors" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1865184 /Source="Nicolas_upshifts" /id="D1078" /incds=0 /nref=128 /ntot=189 /MaxReadThrough="1.75716" /MaxDrop="6.37839" /score="42.3111155" /energy="-14.6" /TU="NA" /idTUdmin="U1603" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1865231..1866631) /gene="ctpA" /locus_tag="BSU_19590" /old_locus_tag="BSU19590" /EC_number="3.4.21.102" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8996100, 10974125, 14526016, 17114254, 19889088; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxy-terminal processing protease (Prc homolog, tail specific protease)" /protein_id="NP_389840.1" /db_xref="EnsemblGenomes-Gn:BSU19590" /db_xref="EnsemblGenomes-Tr:CAB13850" /db_xref="GOA:O34666" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR004447" /db_xref="InterPro:IPR005151" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036034" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG11794" /db_xref="UniProtKB/Swiss-Prot:O34666" /translation="MKRQLKLFFIVLITAVVASALTLFITGNSSILGQKSASTGDSKF DKLNKAYEQIKSDYYQKTDDDKLVDGAIKGMIQSLDDPYSTYMDQEQAKSFDETISAS FEGIGAQVEEKDGEILIVSPIKGSPAEKAGIKPRDQIIKVNGKSVKGMNVNEAVALIR GKKGTKVKLELNRAGVGNIDLSIKRDTIPVETVYSEMKDNNIGEIQITSFSETTAKEL TDAIDSLEKKGAKGYILDLRGNPGGLMEQAITMSNLFIDKGKNIMQVEYKNGSKEVMK AEKERKVTKPTVVLVNDGTASAAEIMAAALHESSNVPLIGETTFGKGTVQTAKEYDDG STVKLTVAKWLTADGEWIHKKGIKPQVKAELPDYAKLPYLDADKTYKSGDTGTNVKVA QKMLKALGYKVKVNSMYDQDFVSVVKQFQKKEKLNETGILTGDTTTKLMIELQKKLSD NDTQMEKAIETLKKEM*" /label="ctpA CDS" gene complement(1865231..1866631) /gene="ctpA" /locus_tag="BSU_19590" /old_locus_tag="BSU19590" /label="ctpA gene" downshifts complement(1865255) /Source="Nicolas_upshifts" /id="D1079" /incds=0 /nref=188 /ntot=292 /MaxReadThrough="0.590400000000001" /MaxDrop="7.62713" /score="34.5981085" /energy="-14.6" /TU="NA" /idTUdmin="U1606" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" promotor_-35 1866402..1866411 /Source="Nicolas_upshift_promotors" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1866423..1866438 /Source="Nicolas_upshift_promotors" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1866437 /Source="Nicolas_upshifts" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1866651..1866670) /Source="Nicolas_upshift_promotors" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1866671) /Source="Nicolas_upshifts" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1866684..1866691) /Source="Nicolas_upshift_promotors" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1866730..1866739 /Source="Nicolas_upshift_promotors" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1866745 /Source="Nicolas_upshifts" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1866752..1866771 /Source="Nicolas_upshift_promotors" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1866784..1867485 /gene="yodH" /locus_tag="BSU_19600" /old_locus_tag="BSU19600" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19703276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative S-adenosylmethionine-dependent methyltransferase" /protein_id="NP_389841.1" /db_xref="EnsemblGenomes-Gn:BSU19600" /db_xref="EnsemblGenomes-Tr:CAB13851" /db_xref="GOA:O34954" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13536" /db_xref="UniProtKB/Swiss-Prot:O34954" /translation="MSRYLEMLSLFGVAGAHPGGLAFSKAVLQKAAPSPDQPILDAGC GTGQTAAYLGHLLYPVTVVDKDPIMLEKAKKRFANEGLAIPAYQAELEHLPFSSESFS CVLSESVLSFSRLTSSLQEISRVLKPSGMLIGIEAALKKPMPPAEKKQMMDFYGFTCL HEESEWHKLLRSYGFQKTEAMSLLPEDMEFEPTTEMDLSQTIDPIYYDTLQTHYQLMQ LYSEYMGHCIFIAYK*" /label="yodH CDS" gene 1866784..1867485 /gene="yodH" /locus_tag="BSU_19600" /old_locus_tag="BSU19600" /label="yodH gene" promotor_-35 1867510..1867518 /Source="Nicolas_upshift_promotors" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1867532..1867551 /Source="Nicolas_upshift_promotors" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1867537 /Source="Nicolas_upshifts" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="upshifts" CDS 1867573..1867824 /gene="yodI" /locus_tag="BSU_19610" /old_locus_tag="BSU19610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816, 22882546, 23155385; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_389842.1" /db_xref="EnsemblGenomes-Gn:BSU19610" /db_xref="EnsemblGenomes-Tr:CAB13852" /db_xref="GOA:O34654" /db_xref="SubtiList:BG13537" /db_xref="UniProtKB/Swiss-Prot:O34654" /translation="MERYYHLCKNHQGKVVRITERGGRVHVGRITRVTRDRVFIAPVG GGPRGFGYGYWGGYWGYGAAYGISLGLIAGVALAGLFFW*" /label="yodI CDS" gene 1867573..1867824 /gene="yodI" /locus_tag="BSU_19610" /old_locus_tag="BSU19610" /label="yodI gene" downshifts 1867845 /Source="Nicolas_upshifts" /id="D1080" /incds=0 /nref=49 /ntot=83 /MaxReadThrough="0.88268" /MaxDrop="7.18785" /score="13.9812819" /energy="-15.5" /TU="NA" /idTUdmin="U1607" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1867895..1868716) /gene="ldcB" /locus_tag="BSU_19620" /old_locus_tag="BSU19620" /EC_number="3.4.16.4" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8631706, 15187182, 24909784" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8631706, 15187182, 24909784; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase lipoprotein (D-ala releasing from tetrapeptide hydrolysis)" /protein_id="NP_389843.1" /db_xref="EnsemblGenomes-Gn:BSU19620" /db_xref="EnsemblGenomes-Tr:CAB13853" /db_xref="GOA:O34866" /db_xref="InterPro:IPR003709" /db_xref="InterPro:IPR009045" /db_xref="PDB:4OX3" /db_xref="SubtiList:BG13538" /db_xref="UniProtKB/Swiss-Prot:O34866" /translation="MKKSGKWFSLAAALSVTAIVGAGCSMSNGDAQKDTKTTAETKQT EQKTADSKKSNTQNSEFSLESQYFNDIKKVDGLETIQNPENILALVNKQYALPGNYEP SDLVIPDVEFSFEEKIQKRYIRKEAADALKTMFDAAKKEGYELAAVSGYRSYDRQKVI FDNEVSLKGERKAKEAVAYPGESEHQTGLAMDISSRSNGFELNEAFGSTADGKWVQDN AYKYGFIIRYPKNKEDITKYEYEPWHLRYVGKKAAKVIQDNDLTLEEYFEKVKKI*" /label="ldcB CDS" gene complement(1867895..1868716) /gene="ldcB" /locus_tag="BSU_19620" /old_locus_tag="BSU19620" /label="ldcB gene" downshifts complement(1867921) /Source="Nicolas_upshifts" /id="D1081" /incds=0 /nref=180 /ntot=242 /MaxReadThrough="0.784690000000001" /MaxDrop="5.88637" /score="-9.13236272" /energy="-6.1" /TU="NA" /idTUdmin="U1609" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1868717..1868798) /Source="Nicolas_S_feature" /locus_tag="new_2135388_2135469_c" /HighExp="dia15, LBGexp, G180, LBGtran, dia0, H2O2, Oxctl, Lbexp, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S755" CDS complement(1868799..1869500) /gene="deoD" /locus_tag="BSU_19630" /old_locus_tag="BSU19630" /EC_number="2.4.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12571059, 16511068, 21279421, 21424839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12571059, 16511068, 21279421, 21424839; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="purine nucleoside phosphorylase" /protein_id="NP_389844.1" /db_xref="EnsemblGenomes-Gn:BSU19630" /db_xref="EnsemblGenomes-Tr:CAB13854" /db_xref="GOA:O34925" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR004402" /db_xref="InterPro:IPR018016" /db_xref="InterPro:IPR035994" /db_xref="PDB:4D8V" /db_xref="PDB:4D8X" /db_xref="PDB:4D8Y" /db_xref="PDB:4D98" /db_xref="PDB:4D9H" /db_xref="PDB:4DA0" /db_xref="PDB:4DA6" /db_xref="PDB:4DA7" /db_xref="PDB:4DA8" /db_xref="PDB:4DAB" /db_xref="PDB:4DAE" /db_xref="PDB:4DAN" /db_xref="PDB:4DAO" /db_xref="PDB:4DAR" /db_xref="SubtiList:BG12581" /db_xref="UniProtKB/Swiss-Prot:O34925" /translation="MSVHIGAEKGQIADTVLLPGDPLRAKFIAETYLENVECYNEVRG MYGFTGTYKGKKISVQGTGMGVPSISIYVNELIQSYDVQNLIRVGSCGAIRKDVKVRD VILAMTSSTDSQMNRVAFGSVDFAPCADFELLKNAYDAAKDKGVPVTVGSVFTADQFY NDDSQIEKLAKYGVLGVEMETTALYTLAAKHGRKALSILTVSDHVLTGEETTAEERQT TFHDMIEVALHSVSQ*" /label="deoD CDS" gene complement(1868799..1869500) /gene="deoD" /locus_tag="BSU_19630" /old_locus_tag="BSU19630" /label="deoD gene" S_feature complement(1869501..1869590) /Source="Nicolas_S_feature" /locus_tag="new_2136172_2136261_c" /HighExp="dia15, G180, dia5, LBGtran, dia0, LBGexp, Lbexp, G150, Oxctl, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S756" promotor_-10 complement(1869575..1869594) /Source="Nicolas_upshift_promotors" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1869590) /Source="Nicolas_upshifts" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1869610..1869614) /Source="Nicolas_upshift_promotors" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1869648..1869654 /Source="Nicolas_upshift_promotors" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1869669..1869680 /Source="Nicolas_upshift_promotors" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1869686 /Source="Nicolas_upshifts" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="upshifts" CDS 1869702..1869827 /gene="yoyE" /locus_tag="BSU_19639" /old_locus_tag="BSU19639" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 24079885" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097743.1" /db_xref="EnsemblGenomes-Gn:BSU19639" /db_xref="EnsemblGenomes-Tr:CAX52640" /db_xref="UniProtKB/Swiss-Prot:C0H432" /translation="MGKKHRNRITGQKKNNHIPEKDIIAAEEAHGKEYSAAKRKP*" /label="yoyE CDS" gene 1869702..1869827 /gene="yoyE" /locus_tag="BSU_19639" /old_locus_tag="BSU19639" /label="yoyE gene" downshifts 1869825 /Source="Nicolas_upshifts" /id="D1082" /incds=0 /nref=9 /ntot=26 /MaxReadThrough="0.67198" /MaxDrop="4.89617" /score="16.4028635" /energy="-8.5" /TU="NA" /idTUdmin="U1610" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1869867..1870181) /gene="yodL" /locus_tag="BSU_19640" /old_locus_tag="BSU19640" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:24079885, 27215790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24079885, 27215790; Product type f: factor" /codon_start=1 /transl_table=11 /product="shape determination factor" /protein_id="NP_389845.2" /db_xref="EnsemblGenomes-Gn:BSU19640" /db_xref="EnsemblGenomes-Tr:CAB13855" /db_xref="InterPro:IPR025923" /db_xref="SubtiList:BG13539" /db_xref="UniProtKB/Swiss-Prot:O30472" /translation="MMLSVFKKKSCSYDVTIFQTPRFGEKKGYRAVYRTELNGSDHQD VLKRAFSLFNVFDTVPSDYDARFMATGDVILIDEGRKGKTYYQLLPAGWRKINRLIVQ TT*" /label="yodL CDS" gene complement(1869867..1870181) /gene="yodL" /locus_tag="BSU_19640" /old_locus_tag="BSU19640" /label="yodL gene" downshifts complement(1869879) /Source="Nicolas_upshifts" /id="D1083" /incds=0 /nref=96 /ntot=232 /MaxReadThrough="1.74792" /MaxDrop="5.79235" /score="-0.334745097" /energy="-8.5" /TU="NA" /idTUdmin="U1611" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1870202..1870220) /Source="Nicolas_upshift_promotors" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1870209) /Source="Nicolas_upshifts" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1870231..1870239) /Source="Nicolas_upshift_promotors" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1870242..1870853) /gene="pgpB" /locus_tag="BSU_19650" /old_locus_tag="BSU19650" /EC_number="3.1.3.27" /EC_number="3.1.3.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 27528508, 28168443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 27528508, 28168443; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylglycerol phosphate (PGP) phosphatase; undecaprenyl-pyrophosphate phosphatase (promiscuous activity)" /protein_id="NP_389846.1" /db_xref="EnsemblGenomes-Gn:BSU19650" /db_xref="EnsemblGenomes-Tr:CAB13856" /db_xref="GOA:O34349" /db_xref="InterPro:IPR000326" /db_xref="InterPro:IPR036938" /db_xref="PDB:5JKI" /db_xref="SubtiList:BG13540" /db_xref="UniProtKB/Swiss-Prot:O34349" /translation="MYKPVSLFLFFLILAAAIHTNAVQSADEAISKAAVLIRQPWLNE VMTGITHLGASSFLLPLIVIIGAGMFFYRKTWDGLLMLLVFGTDRLLNKVLKEWIERV RPDFAPLVHESSFSFPSGHSMNAACVYPVIAYFLVKHLPFLSKHKKMVYIIAGVIAVL VGISRVYLGVHFVTDVLGGFSLGLLLFFLVKGFDEKIKRFRQK*" /label="pgpB CDS" gene complement(1870242..1870853) /gene="pgpB" /locus_tag="BSU_19650" /old_locus_tag="BSU19650" /label="pgpB gene" CDS complement(1870931..1871107) /gene="yozD" /locus_tag="BSU_19660" /old_locus_tag="BSU19660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389847.1" /db_xref="EnsemblGenomes-Gn:BSU19660" /db_xref="EnsemblGenomes-Tr:CAB13857" /db_xref="InterPro:IPR025545" /db_xref="SubtiList:BG13751" /db_xref="UniProtKB/Swiss-Prot:O31863" /translation="MKEIDLVIDTEEIAEFFYRELARRGYIPSEDELFEIADITFDYL IEKCMIDEELDEDE*" /label="yozD CDS" gene complement(1870931..1871107) /gene="yozD" /locus_tag="BSU_19660" /old_locus_tag="BSU19660" /label="yozD gene" downshifts complement(1870935) /Source="Nicolas_upshifts" /id="D1084" /incds=0 /nref=35 /ntot=48 /MaxReadThrough="3.33111" /MaxDrop="5.99901" /score="19.8458751" /energy="-11.9" /TU="U1612,U1613" /idTUdmin="U1615" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1870946) /Source="Nicolas_upshifts" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1870950..1870969) /Source="Nicolas_upshift_promotors" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1870985..1870988) /Source="Nicolas_upshift_promotors" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1871121..1871139) /Source="Nicolas_upshift_promotors" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="promotor_-10" upshifts complement(1871142) /Source="Nicolas_upshifts" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="upshifts" S_feature complement(1871144..1871365) /Source="Nicolas_S_feature" /locus_tag="new_2137815_2138036_c" /HighExp="S8, S7, S6, BT, B36, Pyr, G/S, H2O2, S5, G135" /AntisenseName="yoyF" /AntisenseCor="0.43167183745996701" /AntisenseRegPval="-12.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S757" promotor_-35 complement(1871155..1871160) /Source="Nicolas_upshift_promotors" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="promotor_-35" promotor_-35 1871165..1871170 /Source="Nicolas_upshift_promotors" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1871185..1871203 /Source="Nicolas_upshift_promotors" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1871187 /Source="Nicolas_upshifts" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="upshifts" CDS 1871226..1871369 /gene="yoyF" /locus_tag="BSU_19669" /old_locus_tag="BSU19669" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097744.1" /db_xref="EnsemblGenomes-Gn:BSU19669" /db_xref="EnsemblGenomes-Tr:CAX52641" /db_xref="GOA:C0H433" /db_xref="UniProtKB/Swiss-Prot:C0H433" /translation="MIAKMMEALDGERFDIIMEKTLKGMTRVMIWGCLPYFLYVLIRM FTN*" /label="yoyF CDS" gene 1871226..1871369 /gene="yoyF" /locus_tag="BSU_19669" /old_locus_tag="BSU19669" /label="yoyF gene" CDS complement(1871366..1872046) /gene="yodN" /locus_tag="BSU_19670" /old_locus_tag="BSU19670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389848.1" /db_xref="EnsemblGenomes-Gn:BSU19670" /db_xref="EnsemblGenomes-Tr:CAB13858" /db_xref="SubtiList:BG13541" /db_xref="UniProtKB/Swiss-Prot:O34414" /translation="MKQNKPKFQVGDIVVVIMYGTVGTITKVHQIDKHYLYEVNHNEV LYFESSIQLYKDYEGVIVDMEKLDIEYEFLIGDVVYVKDYGKELFRIIGHRTEIWRYL EDGWEDIIYELTRLKDGEWLETEEEDLTLVLRKYEMDQFVHQLLFVHYVGETGHEIGE DIASSALLQFEGGDEDQDTLHILAVSIVDELLDIYNDYKILYEMFQDEEYKDMMMFVL ESLKEHFS*" /label="yodN CDS" gene complement(1871366..1872046) /gene="yodN" /locus_tag="BSU_19670" /old_locus_tag="BSU19670" /label="yodN gene" S_feature 1871370..1872381 /Source="Nicolas_S_feature" /locus_tag="new_2138041_2139052" /HighExp="LoTm, S3, S8, S7, S4, T5.0H, BT, T4.0H, Pyr, S6" /AntisenseName="yodN" /AntisenseCor="0.52628108909126403" /AntisenseRegPval="-19.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S758" promotor_-10 complement(1872073..1872092) /Source="Nicolas_upshift_promotors" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1872079) /Source="Nicolas_upshifts" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1872106..1872115) /Source="Nicolas_upshift_promotors" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1872197..1872421) /gene="yozE" /locus_tag="BSU_19680" /old_locus_tag="BSU19680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22843344" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389849.1" /db_xref="EnsemblGenomes-Gn:BSU19680" /db_xref="EnsemblGenomes-Tr:CAB13859" /db_xref="InterPro:IPR010673" /db_xref="InterPro:IPR023089" /db_xref="InterPro:IPR036806" /db_xref="PDB:2FJ6" /db_xref="SubtiList:BG13752" /db_xref="UniProtKB/Swiss-Prot:O31864" /translation="MKSFYHYLLKYRHPKPKDSISEFANQAYEDHSFPKTSTDYHEIS SYLELNADYLHTMATFDEAWDQYESEVHGR*" /label="yozE CDS" gene complement(1872197..1872421) /gene="yozE" /locus_tag="BSU_19680" /old_locus_tag="BSU19680" /label="yozE gene" downshifts complement(1872211) /Source="Nicolas_upshifts" /id="D1085" /incds=0 /nref=115 /ntot=243 /MaxReadThrough="1.81033" /MaxDrop="7.07662" /score="34.0666929" /energy="-10.8" /TU="NA" /idTUdmin="U1616" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1872462..1872481) /Source="Nicolas_upshift_promotors" /id="U1616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.619380619380619" /psig="0.983016983016983" /xcortree=637 /SigmaFactorBS="aaacgcaactattttgacttctcctgagtcatgtttcagtat tcttttgttgtAATTTTACACTTGAACTGTAtaatagaacaacaaaagacagacatca g" /listShort="yozE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1872474) /Source="Nicolas_upshifts" /id="U1616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.619380619380619" /psig="0.983016983016983" /xcortree=637 /SigmaFactorBS="aaacgcaactattttgacttctcctgagtcatgtttcagtat tcttttgttgtAATTTTACACTTGAACTGTAtaatagaacaacaaaagacagacatca g" /listShort="yozE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1872508..1872786) /gene="yokU" /locus_tag="BSU_19689" /old_locus_tag="BSU19689" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22843344, 24914178" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097745.1" /db_xref="EnsemblGenomes-Gn:BSU19689" /db_xref="EnsemblGenomes-Tr:CAX52642" /db_xref="InterPro:IPR022451" /db_xref="InterPro:IPR022453" /db_xref="UniProtKB/Swiss-Prot:C0H434" /translation="MKTCEWCGELEAVPGRNTVYWELPDGTRAIELTDTPAMVCSSCG MTYQEENTVKEIEDQLLLIQTKKLPESLTYQQLMETERILKRNYFDFS*" /label="yokU CDS" gene complement(1872508..1872786) /gene="yokU" /locus_tag="BSU_19689" /old_locus_tag="BSU19689" /label="yokU gene" CDS complement(1872783..1874198) /gene="kamA" /locus_tag="BSU_19690" /old_locus_tag="BSU19690" /EC_number="5.4.3.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10629195, 10839984, 11148055, 17254853, 18307109, 21538109" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629195, 10839984, 11148055, 17254853, 18307109, 21538109; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="lysine 2,3-aminomutase" /protein_id="NP_389850.1" /db_xref="EnsemblGenomes-Gn:BSU19690" /db_xref="EnsemblGenomes-Tr:CAB13860" /db_xref="GOA:O34676" /db_xref="InterPro:IPR003739" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022459" /db_xref="InterPro:IPR025895" /db_xref="SubtiList:BG13542" /db_xref="UniProtKB/Swiss-Prot:O34676" /translation="MKNKWYKPKRHWKEIELWKDVPEEKWNDWLWQLTHTVRTLDDLK KVINLTEDEEEGVRISTKTIPLNITPYYASLMDPDNPRCPVRMQSVPLSEEMHKTKYD LEDPLHEDEDSPVPGLTHRYPDRVLFLVTNQCSMYCRYCTRRRFSGQIGMGVPKKQLD AAIAYIRETPEIRDCLISGGDGLLINDQILEYILKELRSIPHLEVIRIGTRAPVVFPQ RITDHLCEILKKYHPVWLNTHFNTSIEMTEESVEACEKLVNAGVPVGNQAVVLAGIND SVPIMKKLMHDLVKIRVRPYYIYQCDLSEGIGHFRAPVSKGLEIIEGLRGHTSGYAVP TFVVDAPGGGGKIALQPNYVLSQSPDKVILRNFEGVITSYPEPENYIPNQADAYFESV FPETADKKEPIGLSAIFADKEVSFTPENVDRIKRREAYIANPEHETLKDRREKRDQLK EKKFLAQQKKQKETECGGDSS*" /label="kamA CDS" gene complement(1872783..1874198) /gene="kamA" /locus_tag="BSU_19690" /old_locus_tag="BSU19690" /label="kamA gene" promotor_-35 1873454..1873457 /Source="Nicolas_upshift_promotors" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1873473..1873492 /Source="Nicolas_upshift_promotors" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1873478 /Source="Nicolas_upshifts" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1874227..1875054) /gene="kamB" /locus_tag="BSU_19700" /old_locus_tag="BSU19700" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:21538109, 24914178" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="epsilon-amino-beta-lysine acetyl transferase" /protein_id="NP_389851.1" /db_xref="EnsemblGenomes-Gn:BSU19700" /db_xref="EnsemblGenomes-Tr:CAB13861" /db_xref="GOA:O34895" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR022525" /db_xref="InterPro:IPR029025" /db_xref="SubtiList:BG13543" /db_xref="UniProtKB/Swiss-Prot:O34895" /translation="MLKSIKSSGVTAVLDHDGFNKRIRVVRYDGAIEKALPDIVAAAK EENAEKIIVYAKQHDEPILAKQLFAPEGYLKGYYLGHSACVMVRYLSESRRQTDSYTE EQEIIEAIYRTAPRLRNDSTPVFTMRKAETNDMYQLSMLYKKVFRTYPTPVFDPAYIE KTMNANTVYYIMLDHDRLISAASAEINPELGHAEITDCAVLPEYRGHSLTSFLIEALE KEMAGEDIVHVFSLARASSFGMNAVLYHSGYQYGGRLINNCFIAEGLENMNIWCKQL* " /label="kamB CDS" gene complement(1874227..1875054) /gene="kamB" /locus_tag="BSU_19700" /old_locus_tag="BSU19700" /label="kamB gene" CDS complement(1875032..1876342) /gene="yodQ" /locus_tag="BSU_19710" /old_locus_tag="BSU19710" /EC_number="3.5.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative deacetylase" /protein_id="NP_389852.1" /db_xref="EnsemblGenomes-Gn:BSU19710" /db_xref="EnsemblGenomes-Tr:CAB13862" /db_xref="GOA:O34984" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010182" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR033687" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12569" /db_xref="UniProtKB/Swiss-Prot:O34984" /translation="MRMQDIERKVIEWLDQHSAKAIRLLKRLIGEKSTLGSEFNAQAV VLEKLRQFHMDIDVWEPSIKQLKQHPYFKSNRSDFHESPNIVAKKTGAGGGRSLILNG HIDVVPEGSVKDWKYEPYQAVEENGKIYGRGSTDMKGGNTALLFALEALHACDVKLKG DVLFQSVVDEECGGAGTLSAIMRGYRADGALIPEPTNMKLFIKQQGSMWFRITVKGLS AHGGTRYEGVSAIEKSMHVITAIQELEKVRNARISDPLYDNIPIPVPVNIGTISGGAW PSSVADRVVIEGRCGIAPHEKPEAVKLELENWLKDLEYHDEWFKRHPVQVEWFGAQWL PNDLPDDHPLISVLQSAYQKMKQTEPIIEASPWGTDGGLLYHAGDTPVIVFGPGETKT AHQANEYIEVEAMIESAKIIALFVMDWCGLHTDGEDADAQVNKE*" /label="yodQ CDS" gene complement(1875032..1876342) /gene="yodQ" /locus_tag="BSU_19710" /old_locus_tag="BSU19710" /label="yodQ gene" CDS complement(1876351..1877004) /gene="yodR" /locus_tag="BSU_19720" /old_locus_tag="BSU19720" /EC_number="2.8.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15150230, 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyloate-acetoacetate CoA-transferase" /protein_id="NP_389853.1" /db_xref="EnsemblGenomes-Gn:BSU19720" /db_xref="EnsemblGenomes-Tr:CAB13863" /db_xref="GOA:O34466" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012791" /db_xref="SubtiList:BG13544" /db_xref="UniProtKB/Swiss-Prot:O34466" /translation="MGLGVAEREQIAKRAATEIKQGMIVNLGIGIPSLVPNFLKPDMQ VMFQAENGVLGIGESPEKGEEDAHLCNAAGYPVRAVKGASYFDTTMSFAMIRKGKIDI TILGALQVSQSGDLANWLVPGKKVPGMGGAMELAQKAKKVVVVMSHTDQKGRPKLTER CTLPLTAAGCVDLIITEKAVLEVDSHHFILKELMNGSTIDEVTRLTEAEIKIDMPFS* " /label="yodR CDS" gene complement(1876351..1877004) /gene="yodR" /locus_tag="BSU_19720" /old_locus_tag="BSU19720" /label="yodR gene" CDS complement(1876989..1877678) /gene="yodS" /locus_tag="BSU_19730" /old_locus_tag="BSU19730" /EC_number="2.8.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15150230, 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxoacid CoA-transferase" /protein_id="NP_389854.1" /db_xref="EnsemblGenomes-Gn:BSU19730" /db_xref="EnsemblGenomes-Tr:CAB13864" /db_xref="GOA:O34317" /db_xref="InterPro:IPR004163" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012792" /db_xref="SubtiList:BG13545" /db_xref="UniProtKB/Swiss-Prot:O34317" /translation="MAPFQKAISIDTAIADVRDGSVLMFGGFGGVGSPPSLIEAILDS GVTDLTVICNDAGFPDIGIGPLIVNQRVKTLIASHIGSNPVAGKQMTEGTLEVQFSPQ GTLAERIRAGGAGLGGILTDVGIDNQMVCEKKDIVTVAGKRYLIEEALTADFAFINAY IADEFGNLTYDKTARNMNPLMAMAARRTFAEAERIVPMGEISEEMIVTPGVFVEGVVR SEGVKWKWAWE*" /label="yodS CDS" gene complement(1876989..1877678) /gene="yodS" /locus_tag="BSU_19730" /old_locus_tag="BSU19730" /label="yodS gene" CDS complement(1877685..1879019) /gene="yodT" /locus_tag="BSU_19740" /old_locus_tag="BSU19740" /EC_number="2.6.1.48" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10839984, 15150230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminovalerate aminotransferase" /protein_id="NP_389855.1" /db_xref="EnsemblGenomes-Gn:BSU19740" /db_xref="EnsemblGenomes-Tr:CAB13865" /db_xref="GOA:O34662" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13546" /db_xref="UniProtKB/Swiss-Prot:O34662" /translation="MSSYLIKPELSSAYPVVSYAKGSYVYDQTGKKYLDGSSGAVTCN IGHGVRDVTEKLKEQLDQVSFAYRSQFTSEPAEQLAALLAQELPGDVNWSFFVNSGSE AIETAMKIAIQYWQEKKQTQKSIFLSRWSSYHGITLGALSLSGFYERRYRFTHLIERY PAISAPHIYRLNHETEEDFVQTAADELDTMIKRIGSQFIAGFVAEPIIGAAGAAITPP PGYYERLSEVCRTHDVLFIADEVMTGLGRTGRMLATEHWDTVPDIAVLGKGLGAGYAP IAAAVVSDSIIETIKQGSGVIMSGHTYSAHPYSAKAALEVLRYVLKHGLIKQSEKKGA VLKKKLDEAASQSGIIGEVRGKGLLLGIEFVADQKTKKVFPPEQAITQLIVSEAKKRG LIVYPSKAGIDSGEGDAVIIAPPFTISDGEMEELISIFSETVAAVEKNLKKD*" /label="yodT CDS" gene complement(1877685..1879019) /gene="yodT" /locus_tag="BSU_19740" /old_locus_tag="BSU19740" /label="yodT gene" CDS complement(1879000..1879155) /locus_tag="BSU_19745" /old_locus_tag="BSU19745" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513966.1" /translation="MLDAEISKEPSLLGRLFLCEKVFAGNVMPPFGHSYNMVKGVLRW EHEQLFD*" /label="conserved hypothetical protein CDS" gene complement(1879000..1879155) /locus_tag="BSU_19745" /old_locus_tag="BSU19745" /label="gene" promotor_-10 complement(1879038..1879056) /Source="Nicolas_upshift_promotors" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1879054) /Source="Nicolas_upshifts" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1879072..1879077) /Source="Nicolas_upshift_promotors" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1879149..1879382) /gene="yoyG" /locus_tag="BSU_19749" /old_locus_tag="BSU19749" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a type I toxin family (sporulation operon)" /protein_id="YP_003097746.2" /db_xref="EnsemblGenomes-Gn:BSU19749" /db_xref="EnsemblGenomes-Tr:CAX52643" /db_xref="GOA:C0H435" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H435" /translation="MSGCILYFIISLHEIGVCTNHLGLGPHKMSYIVIRKDENSMYGY SGYGYGFGCGTNTFVLIVVLFILLIIVGAAFIC*" /label="yoyG CDS" gene complement(1879149..1879382) /gene="yoyG" /locus_tag="BSU_19749" /old_locus_tag="BSU19749" /label="yoyG gene" downshifts complement(1879156) /Source="Nicolas_upshifts" /id="D1086" /incds=0 /nref=96 /ntot=237 /MaxReadThrough="2.70127" /MaxDrop="7.98506" /score="25.3834194" /energy="-16.5" /TU="NA" /idTUdmin="U1620" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" promotor_-35 1879258..1879262 /Source="Nicolas_upshift_promotors" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1879271..1879285 /Source="Nicolas_upshift_promotors" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1879286 /Source="Nicolas_upshifts" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1879287..1879306) /Source="Nicolas_upshift_promotors" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1879296) /Source="Nicolas_upshifts" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1879321..1879330) /Source="Nicolas_upshift_promotors" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1879342..1880121) /gene="cgeE" /locus_tag="BSU_19750" /old_locus_tag="BSU19750" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1729246, 7592393, 10066829, 27260256" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 7592393, 10066829, 27260256; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389856.1" /db_xref="EnsemblGenomes-Gn:BSU19750" /db_xref="EnsemblGenomes-Tr:CAB13866" /db_xref="GOA:P42093" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11197" /db_xref="UniProtKB/Swiss-Prot:P42093" /translation="MTGHYSKTEHQYILLTSESASFDHYSVYRDPQLPQIFSHNFVQL HDTFPLERLLNFLPSVPKLLDANYLHLKASPQHVFPLGLKQSLVKSGFVVEDELLYDM KLSDWKGQMGHPLTAWGTAKSLSDGSSIMKIYDSIYIGEAIAEQKLKRKYPFYEADII ILVVCYSDQAQKVPIGCGELFIDHQEKTAKIEEVAILDQFQRKGYGSILVKEMLSIAK SLGMEAAYLVAASTDGATQFYEKLTFKKYERVHTVFHYFLT*" /label="cgeE CDS" gene complement(1879342..1880121) /gene="cgeE" /locus_tag="BSU_19750" /old_locus_tag="BSU19750" /label="cgeE gene" CDS complement(1880150..1881430) /gene="cgeD" /locus_tag="BSU_19760" /old_locus_tag="BSU19760" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase involved in maturation of the outermost layer of the spore" /protein_id="NP_389857.1" /db_xref="EnsemblGenomes-Gn:BSU19760" /db_xref="EnsemblGenomes-Tr:CAB13867" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11196" /db_xref="UniProtKB/Swiss-Prot:P42092" /translation="MGEKVSIILTSYNKPDYLQKAIESVIQQTHDLWELFIMDDHSNA ETTAVIHKYLHDRRIQYHNSFVHPADRLKTARYATLINSALPFADGDYISYLTDDTVY HPERLSRMVQEFSHKPEAQAVYSKQKVVHVNERGEEISHFYRNANAVLDQAAFQVDHC SVMHRRSLLNLIHHKFGGYWDDDMKHWNHGDAIFWARLNNFTPFLPINEVLDTTYKTP DSFQNAYRFLPADLIDGSFVKGSDQNVYFFDQGVRHPVGEKWGFLYLNRTVAVPDPYL FQYRIGKILNIPNYILVKEADHPAIFYIEAGKKRRIVDQYAFQFYQFQRKDIVTIGKE EMETLPEGPPITWKRSELIKNPPGRRLFFIEREPFLFLNGVFHPISEQVTRKFFLHQK PISASFRNIQQFPIGKPFYPVYDEIIKKLNIATE*" /label="cgeD CDS" gene complement(1880150..1881430) /gene="cgeD" /locus_tag="BSU_19760" /old_locus_tag="BSU19760" /label="cgeD gene" promotor_-10 complement(1880798..1880816) /Source="Nicolas_upshift_promotors" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1880814) /Source="Nicolas_upshifts" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1880830..1880837) /Source="Nicolas_upshift_promotors" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1881398..1881416) /Source="Nicolas_upshift_promotors" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1881408) /Source="Nicolas_upshifts" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1881432..1881437) /Source="Nicolas_upshift_promotors" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1881495..1881800) /gene="cgeC" /locus_tag="BSU_19770" /old_locus_tag="BSU19770" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389858.1" /db_xref="EnsemblGenomes-Gn:BSU19770" /db_xref="EnsemblGenomes-Tr:CAB13868" /db_xref="SubtiList:BG11195" /db_xref="UniProtKB/Swiss-Prot:P42091" /translation="MDLEKQVDREENQDDLHFILLLLILLIRQSSSEGNPSDLRRQLV FAKELGVPVSKVNLINGDTLQNVIVKEVLTDLVIFQNPLNNTRSHVSLSSVVSWGAF* " /label="cgeC CDS" gene complement(1881495..1881800) /gene="cgeC" /locus_tag="BSU_19770" /old_locus_tag="BSU19770" /label="cgeC gene" downshifts complement(1881628) /Source="Nicolas_upshifts" /id="D1087" /incds=1 /nref=2 /ntot=28 /MaxReadThrough="5.32389" /MaxDrop="2.61092" /score="23.1569137" /energy="-13.4" /TU="U1623" /idTUdmin="U1623" /TUdmin="-2310" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1881824..1881843) /Source="Nicolas_upshift_promotors" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="promotor_-10" upshifts complement(1881839) /Source="Nicolas_upshifts" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="upshifts" promotor_-35 complement(1881857..1881866) /Source="Nicolas_upshift_promotors" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="promotor_-35" promotor_-35 1881936..1881945 /Source="Nicolas_upshift_promotors" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1881959..1881978 /Source="Nicolas_upshift_promotors" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1881959 /Source="Nicolas_upshifts" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1881980) /Source="Nicolas_upshifts" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1881982..1881996) /Source="Nicolas_upshift_promotors" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1882005..1882009) /Source="Nicolas_upshift_promotors" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1882005..1882406 /gene="cgeA" /locus_tag="BSU_19780" /old_locus_tag="BSU19780" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:759239, 14702409, 15621419, 19933362, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 759239, 14702409, 15621419, 19933362, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore outermost layer component" /protein_id="NP_389859.1" /db_xref="EnsemblGenomes-Gn:BSU19780" /db_xref="EnsemblGenomes-Tr:CAB13869" /db_xref="SubtiList:BG11193" /db_xref="UniProtKB/Swiss-Prot:P42089" /translation="MSSENAQLKKDLIKAVLSPLFPTATEGGENMDSNLKALLDAAID QKVDESETVTAESILDPSLPARWIFARITPGTTISIVTDSGDMIGPVVFVAFDQVHGI VFVTQESSVTPAGQATTLIDVDKVESVTFFS*" /label="cgeA CDS" gene 1882005..1882406 /gene="cgeA" /locus_tag="BSU_19780" /old_locus_tag="BSU19780" /label="cgeA gene" CDS 1882413..1883366 /gene="cgeB" /locus_tag="BSU_19790" /old_locus_tag="BSU19790" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389860.2" /db_xref="EnsemblGenomes-Gn:BSU19790" /db_xref="EnsemblGenomes-Tr:CAB13870" /db_xref="InterPro:IPR024542" /db_xref="SubtiList:BG11194" /db_xref="UniProtKB/Swiss-Prot:P42090" /translation="MKVLYIQSGYGGIYSYFDRWAEECFQNTHTEYMIADKPEAESLM KIEAFQPDFTLMMVGDRVPHDWLTWLKGKDIPVYVWLTEDPFYMDISLQVIKLADAIL TIEQNAALYYQELGYQNVYYVPIPVNHRLFKKMGTEHSYHSNLLIIGYPYPNRVQLMK EAVHLPFTVRVIGKEWGKYLPKKVLKQPHIDVVSTWVPPEQAVHYYNGADIVINAHRP YHFAFNQNTMRIKNASFNNRTFDIAACEAFQLTDLPAAHPFSSIISYHGMNDFKEKAA FYINHPEERQKAAAANYKETVPAFTFDELPAKLKAIHLALS*" /label="cgeB CDS" gene 1882413..1883366 /gene="cgeB" /locus_tag="BSU_19790" /old_locus_tag="BSU19790" /label="cgeB gene" downshifts 1883356 /Source="Nicolas_upshifts" /id="D1088" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="2.94229" /MaxDrop="5.87549" /score="22.1420541" /energy="-9" /TU="NA" /idTUdmin="U1624" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1883437..1884585) /gene="phyC" /locus_tag="BSU_19800" /old_locus_tag="BSU19800" /EC_number="3.1.3.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10679209, 12101298, 12111145, 12556126, 16980498, 17269748, 21463636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10679209, 12101298, 12111145, 12556126, 16980498, 17269748, 21463636; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phytase" /protein_id="NP_389861.1" /db_xref="EnsemblGenomes-Gn:BSU19800" /db_xref="EnsemblGenomes-Tr:CAB13871" /db_xref="GOA:P42094" /db_xref="InterPro:IPR003431" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG11198" /db_xref="UniProtKB/Swiss-Prot:P42094" /translation="MKVPKTMLLSTAAGLLLSLTATSVSAHYVNEEHHFKVTAHTETD PVASGDDAADDPAIWVHEKHPEKSKLITTNKKSGLVVYDLDGKQLHSYEFGKLNNVDL RYDFPLNGEKIDIAAASNRSEGKNTIEVYAIDGDKGKLKSITDPNHPISTNISEVYGF SLYHSQKTGAFYALVTGKQGEFEQYEIVDGGKGYVTGKKVREFKLNSQTEGLVADDEY GNLYIAEEDEAIWKFNAEPGGGSKGQVVDRATGDHLTADIEGLTIYYAPNGKGYLMAS SQGNNSYAMYERQGKNRYVANFEITDGEKIDGTSDTDGIDVLGFGLGPKYPYGIFVAQ DGENIDNGQAVNQNFKIVSWEQIAQHLGEMPDLHKQVNPRKLKDRSDG*" /label="phyC CDS" gene complement(1883437..1884585) /gene="phyC" /locus_tag="BSU_19800" /old_locus_tag="BSU19800" /label="phyC gene" downshifts complement(1883454) /Source="Nicolas_upshifts" /id="D1089" /incds=0 /nref=16 /ntot=104 /MaxReadThrough="2.64059" /MaxDrop="5.59857" /score="17.7154517" /energy="-8.7" /TU="NA" /idTUdmin="U1629" /TUdmin=2024 /isTUend="FALSE" /label="downshifts" promotor_-35 1884598..1884602 /Source="Nicolas_upshift_promotors" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1884611..1884630) /Source="Nicolas_upshift_promotors" /id="U1626" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=564 /SigmaFactorBS="cagaaaccctataaaaaaaggttcattttcctcacggtaatc acctgtatATATTTTACAATAGTAGTGTtagtgataaaagaggagggtaccaaatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1884618..1884637 /Source="Nicolas_upshift_promotors" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1884620) /Source="Nicolas_upshifts" /id="U1626" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=564 /SigmaFactorBS="cagaaaccctataaaaaaaggttcattttcctcacggtaatc acctgtatATATTTTACAATAGTAGTGTtagtgataaaagaggagggtaccaaatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts 1884628 /Source="Nicolas_upshifts" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1884889..1884897 /Source="Nicolas_upshift_promotors" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1884911..1884930 /Source="Nicolas_upshift_promotors" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1884914 /Source="Nicolas_upshifts" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="upshifts" CDS 1884955..1885980 /NCBI_locus_tag="A8O17_RS10335" /NCBI_old_locus_tag="A8O17_10335" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_014664318.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="polysaccharide biosynthesis protein" /protein_id="WP_003230816.1" /locus_tag="Delta6_BSU_19810-BSU_21670" /modified_by="User" /translation="MPKQQTAELKPFFHNKTVLVTGGTGSIGSQIVKRLLMLTPKQVI VFSKDDSKQYVMSQKYAEDKRLLFVLGDVRDHRRVNQVMKGVDIVFHAAALKQVPTCE DHPFEAIQTNLIGGQNVVEAALSHRVQHVINISTDKAVSPVNTMGATKLLSEKLFHQA NRHVQNKGTLFCSVRFGNVLGSRGSVIPILFEQMMEGEPLTITDKNMTRFFMSIDDAA TLTLQSAAITKGGETFIFKMESLKLEELIHGFEEYASQHGLPRPAAVEVGKRPGEKLH EELTSPHEIESLYEWGNLYAILPEPEKHPDFRKVNLPGYQSDQAPLITKERIAQIIEE LHQEKKA*" /label="Delta6_BSU_19810-BSU_21670" gene 1884955..1885980 /NCBI_locus_tag="A8O17_RS10335" /NCBI_old_locus_tag="A8O17_10335" /locus_tag="Delta6_BSU_19810-BSU_21670" /modified_by="User" /label="Delta6_BSU_19810-BSU_21670" downshifts 1885358 /Source="Nicolas_upshifts" /id="D1090" /incds=0 /nref=18 /ntot=39 /MaxReadThrough="0.75679" /MaxDrop="7.79081" /score="-6.65536786" /energy="-8.7" /TU="NA" /idTUdmin="U1628" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 <1885360..1885364 /Source="Nicolas_upshift_promotors" /id="U1702" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1418 /SigmaFactorBS="tttcatttttgacctcacagccactaATAGTTTCCActaaga aaagtagTAAGTATCTTAAAAAACAGAtaaagctgtatctcctgtgaacacaatgggt g" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-10" SCAR 1885374..1885375 /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="Delta_SP_beta" downshifts 1885972 /Source="Nicolas_upshifts" /id="D1134" /incds=0 /nref=22 /ntot=177 /MaxReadThrough="2.90949" /MaxDrop="5.54327" /score="-2.31796312" /energy="-13.5" /TU="NA" /idTUdmin="U1701" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1886024..1886455) /gene="msrB" /locus_tag="BSU_21680" /old_locus_tag="BSU21680" /EC_number="1.8.4.12" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15680230, 16803968, 17031545, 18239417, 18662407; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide methionine R-sulfoxide reductase" /protein_id="NP_390051.1" /db_xref="EnsemblGenomes-Gn:BSU21680" /db_xref="EnsemblGenomes-Tr:CAB14086" /db_xref="GOA:P54155" /db_xref="InterPro:IPR002579" /db_xref="InterPro:IPR011057" /db_xref="InterPro:IPR028427" /db_xref="PDB:2KZN" /db_xref="PDB:3E0O" /db_xref="SubtiList:BG11628" /db_xref="UniProtKB/Swiss-Prot:P54155" /translation="MAYNKEEKIKSLNRMQYEVTQNNGTEPPFQNEYWDHKEEGLYVD IVSGKPLFTSKDKFDSQCGWPSFTKPIEEEVEEKLDTSHGMIRTEVRSRTADSHLGHV FNDGPGPNGLRYCINSAALRFVPKHKLKEEGYESYLHLFNK*" /label="msrB CDS" gene complement(1886024..1886455) /gene="msrB" /locus_tag="BSU_21680" /old_locus_tag="BSU21680" /label="msrB gene" downshifts complement(1886029) /Source="Nicolas_upshifts" /id="D1135" /incds=0 /nref=229 /ntot=262 /MaxReadThrough="2.46559" /MaxDrop="6.77483" /score="1.42817565" /energy="-12.3" /TU="NA" /idTUdmin="U1704" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(1886456..1886989) /gene="msrA" /locus_tag="BSU_21690" /old_locus_tag="BSU21690" /EC_number="1.8.4.11" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9573155, 16803968, 17062561, 18662407" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9573155, 16803968, 17062561, 18662407; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide methionine S-sulfoxide reductase" /protein_id="NP_390052.1" /db_xref="EnsemblGenomes-Gn:BSU21690" /db_xref="EnsemblGenomes-Tr:CAB14087" /db_xref="GOA:P54154" /db_xref="InterPro:IPR002569" /db_xref="InterPro:IPR036509" /db_xref="SubtiList:BG11627" /db_xref="UniProtKB/Swiss-Prot:P54154" /translation="MSEKKEIATFAGGCFWCMVKPFDEQPGIEKVVSGYTGGHTENPT YEEVCSETTGHREAVQITFHPDVFPYEKLLELFWQQIDPTDAGGQFADRGSSYRAAIF YHNDKQKELAEASKQRLAESGIFKDPIVTDILKAEPFYEAEGYHQHFYKKNPAHYQRY RTGSGRAGFISEHWGAK*" /label="msrA CDS" gene complement(1886456..1886989) /gene="msrA" /locus_tag="BSU_21690" /old_locus_tag="BSU21690" /label="msrA gene" promotor_-35 1886993..1886999 /Source="Nicolas_upshift_promotors" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1887010..1887120 /Source="Nicolas_S_feature" /locus_tag="new_2288083_2288193" /HighExp="B60, Lbstat, Cold, M9-stat, T4.0H, LoTm, S0, T3.30H, BC, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S817" upshifts 1887010 /Source="Nicolas_upshifts" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1887012..1887031 /Source="Nicolas_upshift_promotors" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1887017..1887036) /Source="Nicolas_upshift_promotors" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1887037) /Source="Nicolas_upshifts" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1887052..1887053) /Source="Nicolas_upshift_promotors" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1887121..1887546 /gene="ypoP" /locus_tag="BSU_21700" /old_locus_tag="BSU21700" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9571784, 10809700; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_390053.1" /db_xref="EnsemblGenomes-Gn:BSU21700" /db_xref="EnsemblGenomes-Tr:CAB14088" /db_xref="GOA:P54182" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11626" /db_xref="UniProtKB/Swiss-Prot:P54182" /translation="MKVRTQMMYDMETLLRKVFKQIRNEINEILDKELSRNEFTILRI LSEQGPKKVTEFAPILEVSASHITAVTDALVEKEWITRIRSKEDRRIIRIHITEAGEK VLQHFNEKKTEYFFKRFDCYTDAELATLIELFSKLDKKR*" /label="ypoP CDS" gene 1887121..1887546 /gene="ypoP" /locus_tag="BSU_21700" /old_locus_tag="BSU21700" /label="ypoP gene" downshifts 1887534 /Source="Nicolas_upshifts" /id="D1136" /incds=0 /nref=92 /ntot=248 /MaxReadThrough="4.04021" /MaxDrop="5.35086" /score="-1.90494373" /energy="-7" /TU="U1703" /idTUdmin="U1703" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" S_feature 1887579..1888810 /Source="Nicolas_S_feature" /locus_tag="new_2288652_2289883" /HighExp="Cold, ferm, nit, C30, S0, Lbstat, T3.30H, T-4.40H, T5.0H, G135" /AntisenseName="dinF" /AntisenseCor="0.270994122332881" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S818" CDS complement(1887596..1888933) /gene="dinF" /locus_tag="BSU_21710" /old_locus_tag="BSU21710" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11583854, 15849754, 16850406, 22933559, 26246409; Product type t : transporter" /codon_start=1 /transl_table=11 /product="damage inducible, Na+ driven multidrug efflux pump" /protein_id="NP_390054.1" /db_xref="EnsemblGenomes-Gn:BSU21710" /db_xref="EnsemblGenomes-Tr:CAB14089" /db_xref="GOA:P54181" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG11625" /db_xref="UniProtKB/Swiss-Prot:P54181" /translation="MKAYDFTQGNVLKQLVLFSMPIMLGNALQVSFQFIDSLWIGNLL GAKALGAAAVSSTIVLTVLSFILGLNNATLTILSQQKGKDDIKGMASYINAFVVLLTG LSIGFGAAGFFLSELLLRLLKTPESMIPLAETYLQIQFIGILFLFGYNFISTVLRALG DSKTPLRFIAFAVVLNTVLAPLFISVFRMGIAGAAYSTILSQGIAFLYGLFYVIKHKL VPFSIPRMPKWEESALILKLGIPAGLQMMVITGGMMAIMSVVNSYGDHVVSGFGAVQR LDSIITLPAMAAGTAVNSMAGQNIGIGNEKRVGTIARLGVIAVISCMLVIAVMIWVFG KYLIRLFISEPDAVAFGEQYLKWIAFFYPFIGVNFVLNGIVRAAGAMLQVLVLNLISF WVLRYPFTALFSAWLGQKGIGLGIGMSFLFSSCAAFLYYRYGRWKAMKLFTEK*" /label="dinF CDS" gene complement(1887596..1888933) /gene="dinF" /locus_tag="BSU_21710" /old_locus_tag="BSU21710" /label="dinF gene" CDS complement(1889005..1889199) /gene="ypmT" /locus_tag="BSU_21720" /old_locus_tag="BSU21720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390055.1" /db_xref="EnsemblGenomes-Gn:BSU21720" /db_xref="EnsemblGenomes-Tr:CAB14090" /db_xref="GOA:P54180" /db_xref="InterPro:IPR035403" /db_xref="SubtiList:BG11624" /db_xref="UniProtKB/Swiss-Prot:P54180" /translation="MKRIYQYFSLLSFTFSLYFGWLAYHHLAAEDMDQMYLNVSYCAL FLSVMVFTFGMRDRKKTDKS*" /label="ypmT CDS" gene complement(1889005..1889199) /gene="ypmT" /locus_tag="BSU_21720" /old_locus_tag="BSU21720" /label="ypmT gene" downshifts complement(1889018) /Source="Nicolas_upshifts" /id="D1137" /incds=0 /nref=123 /ntot=248 /MaxReadThrough="3.84998" /MaxDrop="4.80224" /score="-2.26655222" /energy="-15.5" /TU="U1705" /idTUdmin="U1707" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1889212..1889775) /gene="ypmS" /locus_tag="BSU_21730" /old_locus_tag="BSU21730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390056.1" /db_xref="EnsemblGenomes-Gn:BSU21730" /db_xref="EnsemblGenomes-Tr:CAB14091" /db_xref="GOA:P54179" /db_xref="InterPro:IPR018672" /db_xref="SubtiList:BG11623" /db_xref="UniProtKB/Swiss-Prot:P54179" /translation="MNKWKRLFFILLAINFILAAGFVALVLLPGEQAQVKDASESEYG FQVTSTKESLAAFVNSYLNDKASNKLDYKVEIDDDVHVAGKIKAFSTSIDAFIAFEPT VKKNGDVELNVTKFSLGKLSIPISFVLNYMDSFYELPSFVHVHPGDKSIEVRLSEMPL TNGMYVKADKINLEKDEIEFSYYHPKQ*" /label="ypmS CDS" gene complement(1889212..1889775) /gene="ypmS" /locus_tag="BSU_21730" /old_locus_tag="BSU21730" /label="ypmS gene" CDS complement(1889785..1890552) /gene="ypmR" /locus_tag="BSU_21740" /old_locus_tag="BSU21740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17220230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported lipase/acylhydrolase (lipoprotein)" /protein_id="NP_390057.1" /db_xref="EnsemblGenomes-Gn:BSU21740" /db_xref="EnsemblGenomes-Tr:CAB14092" /db_xref="GOA:P40766" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG11022" /db_xref="UniProtKB/Swiss-Prot:P40766" /translation="MKLRIFSIMASLILLLTACTSIRTSSEGKQKAHETKTKEHIVIA AVGDSLTEGVGDPDGKGYVGKVADSIRSDKQVKTVDVKNYAVKGNRSDDLLEKLKDKK VQKGIKDADYVFFTIGGNDLMKILRQNFLQLTVEPFQEAEKPYEKRFEKIISEIRELN DHAELIYVSMYNPFTFTLSELNEINGVVTDWNHIAEKELKKDKHAKIVHIEDLFNQKS DSSRISEEDDFHPNGTGYSLIAKRVYQAIKKEGLPKE*" /label="ypmR CDS" gene complement(1889785..1890552) /gene="ypmR" /locus_tag="BSU_21740" /old_locus_tag="BSU21740" /label="ypmR gene" promotor_-10 complement(1890576..1890595) /Source="Nicolas_upshift_promotors" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1890593) /Source="Nicolas_upshifts" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1890606..1890613) /Source="Nicolas_upshift_promotors" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1890630..1891211) /gene="scuA" /locus_tag="BSU_21750" /old_locus_tag="BSU21750" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10837475, 14680962, 14766920, 16305244, 19027886, 29131589" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10837475, 14680962, 14766920, 16305244, 19027886, 29131589; Product type f : factor" /codon_start=1 /transl_table=11 /product="assembly factor BSco of the Cu(A) site of cytochrome c oxidase" /protein_id="NP_390058.2" /db_xref="EnsemblGenomes-Gn:BSU21750" /db_xref="EnsemblGenomes-Tr:CAB14093" /db_xref="GOA:P54178" /db_xref="InterPro:IPR003782" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:1ON4" /db_xref="PDB:1XZO" /db_xref="SubtiList:BG11622" /db_xref="UniProtKB/Swiss-Prot:P54178" /translation="MKVIKGLTAGLIFLFLCACGGQQIKDPLNYEVEPFTFQNQDGKN VSLESLKGEVWLADFIFTNCETICPPMTAHMTDLQKKLKAENIDVRIISFSVDPENDK PKQLKKFAANYPLSFDNWDFLTGYSQSEIEEFALKSFKAIVKKPEGEDQVIHQSSFYL VGPDGKVLKDYNGVENTPYDDIISDVKSASTLK*" /label="scuA CDS" gene complement(1890630..1891211) /gene="scuA" /locus_tag="BSU_21750" /old_locus_tag="BSU21750" /label="scuA gene" S_feature complement(1891212..1891327) /Source="Nicolas_S_feature" /locus_tag="new_2292285_2292400_c" /HighExp="T5.0H, T3.30H, S2, T3.0H, BC, T2.30H, T4.0H, S1, HiOs, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S819" CDS complement(1891359..1891610) /gene="ypmP" /locus_tag="BSU_21760" /old_locus_tag="BSU21760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15060025, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390059.1" /db_xref="EnsemblGenomes-Gn:BSU21760" /db_xref="EnsemblGenomes-Tr:CAB14094" /db_xref="InterPro:IPR019687" /db_xref="SubtiList:BG11621" /db_xref="UniProtKB/Swiss-Prot:P54177" /translation="MLLKSLEFKRGDGIQVKVTEIPVLKEDEHYFFMLHHHLQFYLKE VFSSNSRAKVYSFRHYMKRRMKWADYQAVFHQEVLKHNA*" /label="ypmP CDS" gene complement(1891359..1891610) /gene="ypmP" /locus_tag="BSU_21760" /old_locus_tag="BSU21760" /label="ypmP gene" downshifts complement(1891372) /Source="Nicolas_upshifts" /id="D1138" /incds=0 /nref=2 /ntot=117 /MaxReadThrough="4.5803" /MaxDrop="2.91481" /score="26.0320926" /energy="-21.8" /TU="U1707" /idTUdmin="U1706" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1891633..1891652) /Source="Nicolas_upshift_promotors" /id="U1706" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=626 /SigmaFactorBS="ttgctaatctaatttttttacacaaccgcgcaaaatgacaga cagcccggctggcATCATATATAATAGAAGAAAaacaaaaaagaggattgatagcttg t" /listShort="ypmP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1891647) /Source="Nicolas_upshifts" /id="U1706" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=626 /SigmaFactorBS="ttgctaatctaatttttttacacaaccgcgcaaaatgacaga cagcccggctggcATCATATATAATAGAAGAAAaacaaaaaagaggattgatagcttg t" /listShort="ypmP" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1891696..1892964) /gene="ilvA" /locus_tag="BSU_21770" /old_locus_tag="BSU21770" /EC_number="4.3.1.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12618455, 13878122, 1459955, 15060025, 18855421, 22094463, 27260660" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12618455, 13878122, 1459955, 15060025, 18855421, 22094463, 27260660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine dehydratase" /protein_id="NP_390060.1" /db_xref="EnsemblGenomes-Gn:BSU21770" /db_xref="EnsemblGenomes-Tr:CAB14095" /db_xref="GOA:P37946" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001721" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR011820" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10673" /db_xref="UniProtKB/Swiss-Prot:P37946" /translation="MKPLLKENSLIQVKDILKAHQNVKDVVIHTPLQRNDRLSERYEC NIYLKREDLQVVRSFKLRGAYHKMKQLSSEQTENGVVCASAGNHAQGVAFSCKHLGIH GKIFMPSTTPRQKVSQVELFGKGFIDIILTGDTFDDAYKSAAECCEAESRTFIHPFDD PDVMAGQGTLAVEILNDIDTEPHFLFASVGGGGLLSGVGTYLKNVSPDTKVIAVEPAG AASYFESNKAGHVVTLDKIDKFVDGAAVKKIGEETFRTLETVVDDILLVPEGKVCTSI LELYNECAVVAEPAGALSVAALDLYKDQIKGKNVVCVVSGGNNDIGRMQEMKERSLIF EGLQHYFIVNFPQRAGALREFLDEVLGPNDDITRFEYTKKNNKSNGPALVGIELQNKA DYGPLIERMNKKPFHYVEVNKDEDLFHLLI*" /label="ilvA CDS" gene complement(1891696..1892964) /gene="ilvA" /locus_tag="BSU_21770" /old_locus_tag="BSU21770" /label="ilvA gene" promotor_-10 complement(1892998..1893017) /Source="Nicolas_upshift_promotors" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1893017) /Source="Nicolas_upshifts" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1893029..1893036) /Source="Nicolas_upshift_promotors" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1893171..1893190 /Source="Nicolas_upshift_promotors" /id="U1708" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3088 /SigmaFactorBS="cctgcagagccaagaaaaaagatgatcgtaaaataaagggtg ttttcaaccaaaaggCATGATATAATGAAACCAATtagaaccaaaaggagccaattga t" /listShort="yplP, yplQ, S820" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1893174 /Source="Nicolas_upshifts" /id="U1708" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3088 /SigmaFactorBS="cctgcagagccaagaaaaaagatgatcgtaaaataaagggtg ttttcaaccaaaaggCATGATATAATGAAACCAATtagaaccaaaaggagccaattga t" /listShort="yplP, yplQ, S820" /GFF_Attribute="listLong" /label="upshifts" CDS 1893213..1894208 /gene="silP" /locus_tag="BSU_21780" /old_locus_tag="BSU21780" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12399512, 16585774, 19763274" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399512, 16585774, 19763274; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional enhancer involved in BCAA homeostasis" /protein_id="NP_390061.1" /db_xref="EnsemblGenomes-Gn:BSU21780" /db_xref="EnsemblGenomes-Tr:CAB14096" /db_xref="GOA:P54156" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013668" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11619" /db_xref="UniProtKB/Swiss-Prot:P54156" /translation="MNSAPKLNTFQHLIGEHQTFLEAKRIAKQFSLSELPVLITGKIG TGKNHFAHAIHLESSRSNEPFISVNCSTHSEETLIHELFGPNGNTGVFQKAVRGTLFL DDVWRMPASVQAQLLKALDSDTEKPRMICASADRSVEHTFRQDLFYRLNILTLTLPEL SERKSDIPLLTQHFLSNSGQQLLIDPSVFPVLEKHAFEGNVRELKNAADYMAAVSSGG TIQPYDLPPYIRGTIDGKTSKKKAKLLTLMEKAEFLFILETIKVLNEKGEPASRRIIS EHSKNTQTSLTPQQVRSRLDYLEKKDYVTKSRGRAGTKITFEGLSFIETLKNQMI*" /label="silP CDS" gene 1893213..1894208 /gene="silP" /locus_tag="BSU_21780" /old_locus_tag="BSU21780" /label="silP gene" CDS 1894229..1894870 /gene="yplQ" /locus_tag="BSU_21790" /old_locus_tag="BSU21790" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16585774, 16850406, 19763274; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_390062.1" /db_xref="EnsemblGenomes-Gn:BSU21790" /db_xref="EnsemblGenomes-Tr:CAB14097" /db_xref="GOA:P54175" /db_xref="InterPro:IPR004254" /db_xref="InterPro:IPR005744" /db_xref="SubtiList:BG11620" /db_xref="UniProtKB/Swiss-Prot:P54175" /translation="MFTIKEEIANAITHGIGVLLSIPALVFLIIFAANYGSAWDIVSF TIFGVSMLLLYLSSTLLHSITHKKTKDILEIIDHSAIYVLIAGTYTPFLLGPLKGTLG FTLLVIVWSLALGGIVFKIFFVKRFILLSTFVYLVMGWLMIIAVKPLYASLSGAGFSL LFLGGILYSVGTIFYIWKKIPFHHAIWHSFVLGGSAAMFFCVLFYCVKVPFLS*" /label="yplQ CDS" gene 1894229..1894870 /gene="yplQ" /locus_tag="BSU_21790" /old_locus_tag="BSU21790" /label="yplQ gene" S_feature 1894871..1895972 /Source="Nicolas_S_feature" /locus_tag="new_2295944_2297045" /HighExp="Cold, C30, Sw, BC, G135, LoTm, Fru, C90, BI, S0" /AntisenseName="ypkP" /AntisenseCor="0.28434605181220002" /AntisenseRegPval="-5.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S820" CDS complement(1894909..1895529) /gene="ypkP" /locus_tag="BSU_21800" /old_locus_tag="BSU21800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 1-acyl-sn-glycerol-3-phosphate acyltransferase" /protein_id="NP_390063.2" /db_xref="EnsemblGenomes-Gn:BSU21800" /db_xref="EnsemblGenomes-Tr:CAB14098" /db_xref="SubtiList:BG11618" /db_xref="UniProtKB/Swiss-Prot:P54174" /translation="MVRYSLLVVYIVYMLLKNMKQLFNQTMLDPRLSYKKQMALVYEQ PKAFLEGCIGISGSVVTIHQPEPIPHGPVLYVHPRLRLAELALIAGYIEEPAGFIANP KVFRLPFIGQWLDRMDVISDGDSEKVYEDVTKQLEKGQSLILSLDGSIDPVELAARYH LPLVMVETKGTDNMQNGSFFKRLKPADIELSFSKAYIPANEKQLRA*" /label="ypkP CDS" gene complement(1894909..1895529) /gene="ypkP" /locus_tag="BSU_21800" /old_locus_tag="BSU21800" /label="ypkP gene" downshifts complement(1894935) /Source="Nicolas_upshifts" /id="D1139" /incds=0 /nref=72 /ntot=241 /MaxReadThrough="1.32187" /MaxDrop="5.02823" /score="16.0584527" /energy="-13.4" /TU="NA" /idTUdmin="U1710" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1895530..1896036) /gene="dfrA" /locus_tag="BSU_21810" /old_locus_tag="BSU21810" /EC_number="1.5.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2840350, 3918568, 10574451, 12682299, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2840350, 3918568, 10574451, 12682299, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydrofolate reductase" /protein_id="NP_390064.1" /db_xref="EnsemblGenomes-Gn:BSU21810" /db_xref="EnsemblGenomes-Tr:CAB14099" /db_xref="GOA:P11045" /db_xref="InterPro:IPR001796" /db_xref="InterPro:IPR012259" /db_xref="InterPro:IPR017925" /db_xref="InterPro:IPR024072" /db_xref="SubtiList:BG10795" /db_xref="UniProtKB/Swiss-Prot:P11045" /translation="MISFIFAMDANRLIGKDNDLPWHLPNDLAYFKKITSGHSIIMGR KTFESIGRPLPNRKNIVVTSAPDSEFQGCTVVSSLKDVLDICSGPEECFVIGGAQLYT DLFPYADRLYMTKIHHEFEGDRHFPEFDESNWKLVSSEQGTKDEKNPYDYEFLMYEKK NSSKAGGF*" /label="dfrA CDS" gene complement(1895530..1896036) /gene="dfrA" /locus_tag="BSU_21810" /old_locus_tag="BSU21810" /label="dfrA gene" CDS complement(1896033..1896827) /gene="thyB" /locus_tag="BSU_21820" /old_locus_tag="BSU21820" /EC_number="2.1.1.45" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9648749, 10574451, 19732150" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9648749, 10574451, 19732150; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate synthase B" /protein_id="NP_390065.1" /db_xref="EnsemblGenomes-Gn:BSU21820" /db_xref="EnsemblGenomes-Tr:CAB14100" /db_xref="GOA:P11044" /db_xref="InterPro:IPR000398" /db_xref="InterPro:IPR020940" /db_xref="InterPro:IPR023451" /db_xref="InterPro:IPR036926" /db_xref="SubtiList:BG10794" /db_xref="UniProtKB/Swiss-Prot:P11044" /translation="MKQYKDFCRHVLEHGEKKGDRTGTGTISTFGYQMRFNLREGFPM LTTKKLHFKSIAHELLWFLKGDTNVRYLQENGVRIWNEWADENGELGPVYGSQWRSWR GADGETIDQISRLIEDIKTNPNSRRLIVSAWNVGEIDKMALPPCHCLFQFYVSDGKLS CQLYQRSADVFLGVPFNIASYALLTMIIAHVTGLEPGEFIHTFGDVHIYQNHIEQVNL QLERDVRPLPQLRFARKVDSIFNFAFEDFIIEDYDPHPHIKGAVSV*" /label="thyB CDS" gene complement(1896033..1896827) /gene="thyB" /locus_tag="BSU_21820" /old_locus_tag="BSU21820" /label="thyB gene" CDS complement(1896911..1897444) /gene="ypjQ" /locus_tag="BSU_21830" /old_locus_tag="BSU21830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8534098; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatidylglycerophosphatase" /protein_id="NP_390066.1" /db_xref="EnsemblGenomes-Gn:BSU21830" /db_xref="EnsemblGenomes-Tr:CAB14101" /db_xref="GOA:P54173" /db_xref="InterPro:IPR007686" /db_xref="InterPro:IPR026038" /db_xref="InterPro:IPR036681" /db_xref="PDB:1TLQ" /db_xref="SubtiList:BG11617" /db_xref="UniProtKB/Swiss-Prot:P54173" /translation="MKKYTMNEMVDITKDMLNKRGVMIEDIARIVQKLQEKYNPNLPL SVCMENVEKVLNKREIIHAVLTGLALDQLAEQKLLPEPLQHLVETDEPLYGIDEIIPL SIVNVYGSIGLTNFGYLDKEKIGIIKELDESPDGIHTFLDDIVAALAAAAASRIAHTH QDLQDEEKEQDEKPVVS*" /label="ypjQ CDS" gene complement(1896911..1897444) /gene="ypjQ" /locus_tag="BSU_21830" /old_locus_tag="BSU21830" /label="ypjQ gene" downshifts complement(1896916) /Source="Nicolas_upshifts" /id="D1140" /incds=0 /nref=17 /ntot=167 /MaxReadThrough="4.91561" /MaxDrop="4.18561" /score="15.5758445" /energy="-9.3" /TU="U1710" /idTUdmin="U1711" /TUdmin=1232 /isTUend="FALSE" /label="downshifts" promotor_-35 1897374..1897379 /Source="Nicolas_upshift_promotors" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1897390..1898336 /Source="Nicolas_S_feature" /locus_tag="new_2298463_2299409" /HighExp="S5, S6, S4, S8, S7, S3, B36, BT, B60, T5.0H" /AntisenseName="ypjP" /AntisenseCor="-0.72590712604537599" /AntisenseRegPval="-44.6" /CDS_PredictionProba="0.99932399999999999" /TUshortSig="SigEF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S821" upshifts 1897392 /Source="Nicolas_upshifts" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1897396..1897414 /Source="Nicolas_upshift_promotors" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1897462..1898073) /gene="ypjP" /locus_tag="BSU_21840" /old_locus_tag="BSU21840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390067.1" /db_xref="EnsemblGenomes-Gn:BSU21840" /db_xref="EnsemblGenomes-Tr:CAB14102" /db_xref="GOA:P54172" /db_xref="InterPro:IPR025616" /db_xref="SubtiList:BG11616" /db_xref="UniProtKB/Swiss-Prot:P54172" /translation="MKLWMRKTLVVLFTIVTFGLVSPPAALMADKPSGQPSSLEQNDY TAFYDEHDLYDDESDDRRDPELLFQSYKEQLLDSAEDQSFLKFGSRIAPVIEDDYRKE ILPKIENVISDYLATLQDDEAYQDVVISSMPSAGKTEKIFNVYNRTTGEDLLRFHVRR DHPPHDGYWFNFHYHTAEDGFQSHHELGSIYWDRNTPPNWMSA*" /label="ypjP CDS" gene complement(1897462..1898073) /gene="ypjP" /locus_tag="BSU_21840" /old_locus_tag="BSU21840" /label="ypjP gene" promotor_-10 complement(1898105..1898124) /Source="Nicolas_upshift_promotors" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1898124) /Source="Nicolas_upshifts" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1898137..1898142) /Source="Nicolas_upshift_promotors" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1898293 /Source="Nicolas_upshifts" /id="D1141" /incds=0 /nref=57 /ntot=234 /MaxReadThrough="3.131" /MaxDrop="5.18613" /score="2.81720493" /energy="-15" /TU="U1709" /idTUdmin="U1709" /TUdmin="-527" /isTUend="FALSE" /label="downshifts" CDS complement(1898333..1899106) /gene="rsmJ" /locus_tag="BSU_21850" /old_locus_tag="BSU21850" /EC_number="2.1.1.242" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22079366; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 16S rRNA m(2)G1516 methyltransferase" /protein_id="NP_390068.2" /db_xref="EnsemblGenomes-Gn:BSU21850" /db_xref="EnsemblGenomes-Tr:CAB14103" /db_xref="GOA:P54171" /db_xref="InterPro:IPR007536" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11615" /db_xref="UniProtKB/Swiss-Prot:P54171" /translation="MITTSYRPSEHTIKTAKQLSKELNMPYCGRNKQTVEHLLKSAER DLLVVGKERFELYTKQGAKFFFHPNTAMFRAKRFLQGEKEPMLRAAGLSEGDTFLDCT LGLGSDAIIASMAVGETGSVVGIEKNHLVSVLVRTGLHSWETGIEELQAAMRRIQVKN GDCFEHIKQLPDNSVDVVYFDPMFHEPVETSDGIAPLRDLAEDSVLHEGCINEAVRVA RKSVVLKDHWKSPRFEQFGFNVMKRKTALFHYGVIQTSP*" /label="rsmJ CDS" gene complement(1898333..1899106) /gene="rsmJ" /locus_tag="BSU_21850" /old_locus_tag="BSU21850" /label="rsmJ gene" downshifts complement(1898368) /Source="Nicolas_upshifts" /id="D1142" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="2.86923" /MaxDrop="2.91228" /score="9.10717118" /energy="-15" /TU="U1711" /idTUdmin="U1711" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(1899148..1899582) /gene="brxA" /locus_tag="BSU_21860" /old_locus_tag="BSU21860" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:19653655, 21749987, 22938038, 24313874, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19653655, 21749987, 22938038, 24313874, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein disulfide isomerase; bacilliredoxin A (de-bacillithiolation)" /protein_id="NP_390069.1" /db_xref="EnsemblGenomes-Gn:BSU21860" /db_xref="EnsemblGenomes-Tr:CAB14104" /db_xref="InterPro:IPR009474" /db_xref="PDB:3FHK" /db_xref="SubtiList:BG11614" /db_xref="UniProtKB/Swiss-Prot:P54170" /translation="MSMAYEEYMRQLVVPMRRELTGAGFEELTTAEEVENFMEKAEGT TLVVVNSVCGCAAGLARPAATQAVLQNDKTPDNTVTVFAGQDKEATAKMREYFTGQEP SSPSMALLKGKEVVHFIPRHEIEGHDMEEIMKNLTAAFDAHC*" /label="brxA CDS" gene complement(1899148..1899582) /gene="brxA" /locus_tag="BSU_21860" /old_locus_tag="BSU21860" /label="brxA gene" downshifts complement(1899160) /Source="Nicolas_upshifts" /id="D1143" /incds=0 /nref=9 /ntot=210 /MaxReadThrough="5.2935" /MaxDrop="3.1992" /score="21.0933404" /energy="-9.7" /TU="U1711,U1712" /idTUdmin="U1712" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1899611..1899630) /Source="Nicolas_upshift_promotors" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="promotor_-10" upshifts complement(1899622) /Source="Nicolas_upshifts" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="upshifts" S_feature complement(1899624..1899688) /Source="Nicolas_S_feature" /locus_tag="new_2300697_2300761_c" /HighExp="Sw, S1, BC, Gly, HiOs, HiTm, GM-0.1, UNK1, Fru, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S822" promotor_-35 complement(1899644..1899651) /Source="Nicolas_upshift_promotors" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="promotor_-35" downshifts complement(1899667) /Source="Nicolas_upshifts" /id="D1144" /incds=0 /nref=32 /ntot=128 /MaxReadThrough="5.73826" /MaxDrop="4.95094" /score="26.9702838" /energy="-25.8" /TU="U1712" /idTUdmin="U1713" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1899689..1901365) /gene="ilvD" /locus_tag="BSU_21870" /old_locus_tag="BSU21870" /EC_number="4.2.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12193635, 12618455, 15060025, 24163341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193635, 12618455, 15060025, 24163341; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroxy-acid dehydratase" /protein_id="NP_390070.2" /db_xref="EnsemblGenomes-Gn:BSU21870" /db_xref="EnsemblGenomes-Tr:CAB14105" /db_xref="GOA:P51785" /db_xref="InterPro:IPR000581" /db_xref="InterPro:IPR004404" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR020558" /db_xref="SubtiList:BG11532" /db_xref="UniProtKB/Swiss-Prot:P51785" /translation="MAELRSNMITQGIDRAPHRSLLRAAGVKEEDFGKPFIAVCNSYI DIVPGHVHLQEFGKIVKEAIREAGGVPFEFNTIGVDDGIAMGHIGMRYSLPSREIIAD SVETVVSAHWFDGMVCIPNCDKITPGMLMAAMRINIPTIFVSGGPMAAGRTSDGRKIS LSSVFEGVGAYQAGKINENELQELEQFGCPTCGSCSGMFTANSMNCLSEALGLALPGN GTILATSPERKEFVRKSAAQLMETIRKDIKPRDIVTVKAIDNAFALDMALGGSTNTVL HTLALANEAGVEYSLERINEVAERVPHLAKLAPASDVFIEDLHEAGGVSAALNELSKK EGALHLDALTVTGKTLGETIAGHEVKDYDVIHPLDQPFTEKGGLAVLFGNLAPDGAII KTGGVQNGITRHEGPAVVFDSQDEALDGIINRKVKEGDVVIIRYEGPKGGPGMPEMLA PTSQIVGMGLGPKVALITDGRFSGASRGLSIGHVSPEAAEGGPLAFVENGDHIIVDIE KRILDVQVPEEEWEKRKANWKGFEPKVKTGYLARYSKLVTSANTGGIMKI*" /label="ilvD CDS" gene complement(1899689..1901365) /gene="ilvD" /locus_tag="BSU_21870" /old_locus_tag="BSU21870" /label="ilvD gene" S_feature complement(1901366..1901556) /Source="Nicolas_S_feature" /locus_tag="new_2302439_2302629_c" /HighExp="S1, T-5.40H, MG 45, HiOs, T-4.40H, MG 120, UNK1, MG 25, MG-0.2, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.97" /TUlongSig="SigH" /TUlongPSig=1 /label="S823" promotor_-10 complement(1901545..1901564) /Source="Nicolas_upshift_promotors" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1901556) /Source="Nicolas_upshifts" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1901579..1901582) /Source="Nicolas_upshift_promotors" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1901654..1902787) /gene="ypgR" /locus_tag="BSU_21880" /old_locus_tag="BSU21880" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase or scaffold" /protein_id="NP_390071.1" /db_xref="EnsemblGenomes-Gn:BSU21880" /db_xref="EnsemblGenomes-Tr:CAB14106" /db_xref="InterPro:IPR004155" /db_xref="InterPro:IPR014824" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR025989" /db_xref="InterPro:IPR036498" /db_xref="SubtiList:BG11613" /db_xref="UniProtKB/Swiss-Prot:P54169" /translation="MKIKSIEPTPSPNTMKVILTEELPAGKSNNYKPEQAEGAPLVIA EILKIDGVKGVYHVADFLAVERNARYDWKDILPQVRTAFGMESAESAEENRSDQESFG EVKVFVQMFSGIPMQVKLTDGEREERFGLPERFQQAILKLRSEASNVVFERAWKEQGV RFGDFDEIGHDVTEELQAAYSDERLKRLTEAAAQGKGEAKQAVQRKAYKVTLDMLDDE DWKKRYAHLEQMDPKEEDIPVLQKALDDPKVSIRRQAVVYLGMIETPDVLPLLYKALE DKAVSVRRTAGDCLSDIGDPQAIPAMIKSLSDSSKLVRWRAAMFLYEVGDESAIEALR AAEDDPEFEVSLQVKMALERIEHGEEAKGSVWKQMTESRKKGE*" /label="ypgR CDS" gene complement(1901654..1902787) /gene="ypgR" /locus_tag="BSU_21880" /old_locus_tag="BSU21880" /label="ypgR gene" downshifts complement(1901670) /Source="Nicolas_upshifts" /id="D1145" /incds=0 /nref=193 /ntot=249 /MaxReadThrough="5.33526" /MaxDrop="6.88149" /score="18.2078317" /energy="-8.7" /TU="U1713" /idTUdmin="U1714" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" misc_feature complement(1902809..1902828) /Source="Nicolas_upshift_promotors" /id="U1713" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.618381618381618" /psig="0.97002997002997" /xcortree=1972 /SigmaFactorBS="ccgggattgatgccgaaacgtcgtaatagaaggcttggagcg acTATGATAGAATAAGTCACAGatatgctataggaggacgatcatgaagataaaatca a" /listShort="ypgR, S823, ilvD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1902812) /Source="Nicolas_upshifts" /id="U1713" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.618381618381618" /psig="0.97002997002997" /xcortree=1972 /SigmaFactorBS="ccgggattgatgccgaaacgtcgtaatagaaggcttggagcg acTATGATAGAATAAGTCACAGatatgctataggaggacgatcatgaagataaaatca a" /listShort="ypgR, S823, ilvD" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1902847..1903464) /gene="hdhQ" /locus_tag="BSU_21890" /old_locus_tag="BSU21890" /EC_number="3.6.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:25005104, 27062940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25005104, 27062940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Mn(2+)-dependent (deoxy)ribonucleoside pyrophosphohydrolase" /protein_id="NP_390072.1" /db_xref="EnsemblGenomes-Gn:BSU21890" /db_xref="EnsemblGenomes-Tr:CAB14107" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG11612" /db_xref="UniProtKB/Swiss-Prot:P54168" /translation="MKELKQAEQIRTWVQSILTDESSGHDWHHVSRVADLAAYIGEKE KADLFIVETAALVHDLIDVKLPDTVRLSVSEVYDQLVFFGVGKENADRVIHIITRMSF RDRGKLAKEPLSIEGKAVQDADRLDAIGAVGIARAFMFAGAKGHGLYGDEQSAYAHFF HKLLRLKDMMNTDTARELAEERHNFMLQFVRQLEKDIPGIDAETS*" /label="hdhQ CDS" gene complement(1902847..1903464) /gene="hdhQ" /locus_tag="BSU_21890" /old_locus_tag="BSU21890" /label="hdhQ gene" CDS complement(1903480..1903962) /gene="bsaA" /locus_tag="BSU_21900" /old_locus_tag="BSU21900" /EC_number="1.11.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14563871, 14617062, 21749987, 25852656; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillithiol peroxidase" /protein_id="NP_390073.1" /db_xref="EnsemblGenomes-Gn:BSU21900" /db_xref="EnsemblGenomes-Tr:CAB14108" /db_xref="GOA:P52035" /db_xref="InterPro:IPR000889" /db_xref="InterPro:IPR029759" /db_xref="InterPro:IPR029760" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11530" /db_xref="UniProtKB/Swiss-Prot:P52035" /translation="MSIYHMKVRTITGKDMTLQPFAGKVLMIVNTASKCGFTSQLKQL QELYDTYQQEGLEILGFPCNQFMNQEPGEEADIQEFCETNYGVTFPMFSKVDVNGKNA HPLFVYLTEHAKGMLGTKAIKWNFTKFIVDRNGEIVGRYSPNTNPKELEDDIVKLLEQ *" /label="bsaA CDS" gene complement(1903480..1903962) /gene="bsaA" /locus_tag="BSU_21900" /old_locus_tag="BSU21900" /label="bsaA gene" S_feature complement(1903963..1904110) /Source="Nicolas_S_feature" /locus_tag="new_2305036_2305183_c" /HighExp="S2, HiOs, S1, Etha, T2.30H, T3.0H, Lbtran, M0t90, T2.0H, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S824" promotor_-10 complement(1904101..1904119) /Source="Nicolas_upshift_promotors" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="promotor_-10" upshifts complement(1904111) /Source="Nicolas_upshifts" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="upshifts" promotor_-35 complement(1904130..1904138) /Source="Nicolas_upshift_promotors" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="promotor_-35" promotor_-35 1904164..1904173 /Source="Nicolas_upshift_promotors" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-35" promotor_-10 1904186..1904201 /Source="Nicolas_upshift_promotors" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-10" S_feature 1904188..1904274 /Source="Nicolas_S_feature" /locus_tag="new_2305261_2305347" /HighExp="Salt, T-0.40H, T-1.10H, Heat, T-1.40H, H2O2, T0.0H, Paraq, T0.30H, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S825" upshifts 1904188 /Source="Nicolas_upshifts" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="upshifts" promotor_-35 1904237..1904244 /Source="Nicolas_upshift_promotors" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-35" promotor_-10 1904259..1904278 /Source="Nicolas_upshift_promotors" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-10" upshifts 1904276 /Source="Nicolas_upshifts" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="upshifts" CDS 1904305..1905210 /gene="metAA" /locus_tag="BSU_21910" /old_locus_tag="BSU21910" /EC_number="2.3.1.31" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:5001847, 10939241, 11832514, 17056751, 18216013, 28581482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 5001847, 10939241, 11832514, 17056751, 18216013, 28581482; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="homoserine O-acetyltransferase" /protein_id="NP_390074.2" /db_xref="EnsemblGenomes-Gn:BSU21910" /db_xref="EnsemblGenomes-Tr:CAB14109" /db_xref="GOA:P54167" /db_xref="InterPro:IPR005697" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR033752" /db_xref="SubtiList:BG11534" /db_xref="UniProtKB/Swiss-Prot:P54167" /translation="MPINIPTHLPAKQVLESEHIFVMDESRAFHQDIRPQKIIILNLM PKKIQTETQLLRLLGNSPLQVHFTFLIPSTHTPKNTAREHLDEFYTTFSNIRHKRFDG MIITGAPIEHLAFEEVSYWEELKEIMEWSKTNVTSTLHICWGAQAGLYYHYGVEKIQM PKKIFGVFEHTVLSKHERLVRGFDELYYVPHSRHTDINMEQLQAVPELNILTASKEAG VCLIVSKDEKQVFLTGHPEYDTNTLLQEYERDLERNLSTVEAPKHYFAKGSNEPVNRW KAHATLLFMNWLNYYVYQETPYEWD*" /label="metAA CDS" gene 1904305..1905210 /gene="metAA" /locus_tag="BSU_21910" /old_locus_tag="BSU21910" /label="metAA gene" misc_feature 1905245..1905264 /Source="Nicolas_upshift_promotors" /id="U1717" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=2287 /SigmaFactorBS="gaatgggactaatttttctttttttagtgatacgctgagcaa aaaaTATGATAAAATACATCTGATtcagtctgcgtataacaaaaatttaaaatactgg a" /listShort="S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1905259 /Source="Nicolas_upshifts" /id="U1717" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=2287 /SigmaFactorBS="gaatgggactaatttttctttttttagtgatacgctgagcaa aaaaTATGATAAAATACATCTGATtcagtctgcgtataacaaaaatttaaaatactgg a" /listShort="S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="upshifts" S_feature 1905260..1905440 /Source="Nicolas_S_feature" /locus_tag="new_2306333_2306513" /HighExp="Heat, HiTm, LoTm, C90, M9-stat, HiOs, SMM, UNK1, MG 25, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigWXY" /TUshortPSig="0.999, 0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S826" CDS 1905441..1906589 /gene="ugtP" /locus_tag="BSU_21920" /old_locus_tag="BSU21920" /EC_number="2.4.1.315" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11344159, 17209021, 17662947, 9720862, 18820022, 22362028, 22931116, 27684739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344159, 17209021, 17662947, 9720862, 18820022, 22362028, 22931116, 27684739; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose diacylglyceroltransferase" /protein_id="NP_390075.1" /db_xref="EnsemblGenomes-Gn:BSU21920" /db_xref="EnsemblGenomes-Tr:CAB14110" /db_xref="GOA:P54166" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR009695" /db_xref="InterPro:IPR023589" /db_xref="SubtiList:BG11611" /db_xref="UniProtKB/Swiss-Prot:P54166" /translation="MNTNKRVLILTANYGNGHVQVAKTLYEQCVRLGFQHVTVSNLYQ ESNPIVSEVTQYLYLKSFSIGKQFYRLFYYGVDKIYNKRKFNIYFKMGNKRLGELVDE HQPDIIINTFPMIVVPEYRRRTGRVIPTFNVMTDFCLHKIWVHENVDKYYVATDYVKE KLLEIGTHPSNVKITGIPIRPQFEESMPVGPIYKKYNLSPNKKVLLIMAGAHGVLKNV KELCENLVKDDQVQVVVVCGKNTALKESLSALEAENGDKLKVLGYVERIDELFRITDC MITKPGGITLTEATAIGVPVILYKPVPGQEKENANFFEDRGAAIVVNRHEEILESVTS LLADEDTLHRMKKNIKDLHLANSSEVILEDILKESEMMTAKQKAKVLS*" /label="ugtP CDS" gene 1905441..1906589 /gene="ugtP" /locus_tag="BSU_21920" /old_locus_tag="BSU21920" /label="ugtP gene" S_feature complement(1905610..1906639) /Source="Nicolas_S_feature" /locus_tag="new_2306683_2307712_c" /HighExp="S8, S7, S6, C30, Lbstat, T0.30H, C90, BT, G135, Fru" /AntisenseName="ugtP" /AntisenseCor="-0.328222465122327" /AntisenseRegPval="-7.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S827" downshifts 1906585 /Source="Nicolas_upshifts" /id="D1146" /incds=0 /nref=77 /ntot=240 /MaxReadThrough="4.0787" /MaxDrop="4.20549" /score="21.6989702" /energy="-12.1" /TU="U1715,U1717" /idTUdmin="U1716" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1906621..1906640) /Source="Nicolas_upshift_promotors" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1906639) /Source="Nicolas_upshifts" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1906655..1906663) /Source="Nicolas_upshift_promotors" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1906670..1906816 /locus_tag="BSU_21925" /old_locus_tag="BSU21925" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513973.1" /translation="MELALLLKNKPFRNLTGAPRWCIVEPSFNNESKLDDDKIFFSTW VLQY*" /label="hypothetical protein CDS" gene 1906670..1906816 /locus_tag="BSU_21925" /old_locus_tag="BSU21925" /label="gene" promotor_-35 1906709..1906716 /Source="Nicolas_upshift_promotors" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1906730..1906749 /Source="Nicolas_upshift_promotors" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1906741..1906831 /Source="Nicolas_S_feature" /locus_tag="new_2307814_2307904" /HighExp="C90, T5.0H, T3.30H, T3.0H, HiOs, Salt, LoTm, T-3.40H, S3, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA, SigA, SigWXY" /TUlongPSig="0.999, 0.995, 1" /label="S828" upshifts 1906741 /Source="Nicolas_upshifts" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="upshifts" CDS 1906832..1907032 /gene="cspD" /locus_tag="BSU_21930" /old_locus_tag="BSU21930" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9920884, 16352840" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9920884, 16352840; Product type f: factor" /codon_start=1 /transl_table=11 /product="cold-shock protein, molecular chaperone, RNA-helicase co-factor" /protein_id="NP_390076.1" /db_xref="EnsemblGenomes-Gn:BSU21930" /db_xref="EnsemblGenomes-Tr:CAB14111" /db_xref="GOA:P51777" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="SubtiList:BG11531" /db_xref="UniProtKB/Swiss-Prot:P51777" /translation="MQNGKVKWFNNEKGFGFIEVEGGDDVFVHFTAIEGDGYKSLEEG QEVSFEIVEGNRGPQASNVVKL*" /label="cspD CDS" gene 1906832..1907032 /gene="cspD" /locus_tag="BSU_21930" /old_locus_tag="BSU21930" /label="cspD gene" downshifts 1907047 /Source="Nicolas_upshifts" /id="D1147" /incds=0 /nref=257 /ntot=269 /MaxReadThrough="5.19931" /MaxDrop="8.09346" /score="9.24662311" /energy="-15.6" /TU="U1719" /idTUdmin="U1715" /TUdmin=308 /isTUend="FALSE" /label="downshifts" CDS complement(1907084..1907266) /gene="degR" /locus_tag="BSU_21940" /old_locus_tag="BSU21940" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16625836, 19251843, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16625836, 19251843, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="activator of degradative enzymes (aprE, nprE, sacB) production or activity" /protein_id="NP_390077.1" /db_xref="EnsemblGenomes-Gn:BSU21940" /db_xref="EnsemblGenomes-Tr:CAB14112" /db_xref="GOA:P68731" /db_xref="SubtiList:BG10699" /db_xref="UniProtKB/Swiss-Prot:P68731" /translation="MDDKDLKLILHKTFIEIYSDLEELADIAKKGKPSMEKYVEEIEQ RCKQNILAIEIQMKIK*" /label="degR CDS" gene complement(1907084..1907266) /gene="degR" /locus_tag="BSU_21940" /old_locus_tag="BSU21940" /label="degR gene" S_feature 1907092..1907397 /Source="Nicolas_S_feature" /locus_tag="new_2308165_2308470" /HighExp="Cold, LoTm, T4.0H, T3.30H, Pyr, T5.0H, Gly, T3.0H, S0, C30" /AntisenseName="degR" /AntisenseCor="-0.145220711637392" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA, SigA, SigWXY" /TUlongPSig="0.999, 0.995, 1" /label="S829" downshifts complement(1907101) /Source="Nicolas_upshifts" /id="D1148" /incds=0 /nref=133 /ntot=216 /MaxReadThrough="3.75638" /MaxDrop="5.32427" /score="16.1392275" /energy="-7.3" /TU="U1720" /idTUdmin="U1720" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1907327..1907345) /Source="Nicolas_upshift_promotors" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1907359..1907365) /Source="Nicolas_upshift_promotors" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1907363) /Source="Nicolas_upshifts" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1907373..1907379 /Source="Nicolas_upshift_promotors" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1907394..1907405 /Source="Nicolas_upshift_promotors" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1907399 /Source="Nicolas_upshifts" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="upshifts" CDS 1907422..1907691 /gene="ypzA" /locus_tag="BSU_21950" /old_locus_tag="BSU21950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816, 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390078.1" /db_xref="EnsemblGenomes-Gn:BSU21950" /db_xref="EnsemblGenomes-Tr:CAB14113" /db_xref="InterPro:IPR020314" /db_xref="SubtiList:BG13764" /db_xref="UniProtKB/Swiss-Prot:O32007" /translation="MTSEFHNEDQTGFTDKRQLELAVETAQKTTGAATRGQSKTLVDS AYQAIEDARELSQSEELAALDDPEFVKQQQQLLDDSEHQLDEFKE*" /label="ypzA CDS" gene 1907422..1907691 /gene="ypzA" /locus_tag="BSU_21950" /old_locus_tag="BSU21950" /label="ypzA gene" downshifts 1907546 /Source="Nicolas_upshifts" /id="D1149" /incds=1 /nref=3 /ntot=82 /MaxReadThrough="6.79633" /MaxDrop="4.11501" /score="22.0113838" /energy="-7.3" /TU="U1719,U1721" /idTUdmin="U1719" /TUdmin="-117" /isTUend="FALSE" /label="downshifts" downshifts 1907674 /Source="Nicolas_upshifts" /id="D1150" /incds=0 /nref=18 /ntot=94 /MaxReadThrough="2.31821" /MaxDrop="6.65627" /score="22.0113838" /energy="-7.3" /TU="NA" /idTUdmin="U1719" /TUdmin=11 /isTUend="TRUE" /label="downshifts" CDS complement(1907719..1907901) /gene="ypeQ" /locus_tag="BSU_21960" /old_locus_tag="BSU21960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390079.1" /db_xref="EnsemblGenomes-Gn:BSU21960" /db_xref="EnsemblGenomes-Tr:CAB14114" /db_xref="InterPro:IPR019718" /db_xref="SubtiList:BG11610" /db_xref="UniProtKB/Swiss-Prot:P54165" /translation="MDKKMIFKELTELHDEYCKDCFIKKQFRKEFGKTYAHSFCINKC TVGEKLKQYGDVLTNH*" /label="ypeQ CDS" gene complement(1907719..1907901) /gene="ypeQ" /locus_tag="BSU_21960" /old_locus_tag="BSU21960" /label="ypeQ gene" downshifts complement(1907739) /Source="Nicolas_upshifts" /id="D1151" /incds=0 /nref=5 /ntot=102 /MaxReadThrough="2.77117" /MaxDrop="4.29218" /score="16.1392275" /energy="-7.3" /TU="NA" /idTUdmin="U1723" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1907894..1908574) /gene="ypeP" /locus_tag="BSU_21970" /old_locus_tag="BSU21970" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12562816, 17905985, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 17905985, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease" /protein_id="NP_390080.2" /db_xref="EnsemblGenomes-Gn:BSU21970" /db_xref="EnsemblGenomes-Tr:CAB14115" /db_xref="GOA:P54164" /db_xref="InterPro:IPR002156" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11609" /db_xref="UniProtKB/Swiss-Prot:P54164" /translation="MKLRPHLKIEAKGTGSVSFFSEDWLTAQQARTFARELGRFPYMK ELEFEDEKGGSWTLKELEKLTEELAQEPDDITVYFDGSFDKESELAGLGIVIYYSLGG TRHRLRKNKSFRLKTNNEAEYAALYEAIREVRELGASRNSITIKGDSLVVLNQLDGSW PCYDPSHNEWLDKIEALLESLKLTPTYETIQRKDNQEADGLAKKILSHQFVESHTKLD RNGDDDIG*" /label="ypeP CDS" gene complement(1907894..1908574) /gene="ypeP" /locus_tag="BSU_21970" /old_locus_tag="BSU21970" /label="ypeP gene" S_feature complement(1908575..1908712) /Source="Nicolas_S_feature" /locus_tag="new_2309648_2309785_c" /HighExp="S5, S4, S6, S8, S7, S3, T5.0H, T4.0H, BT, Pyr" /AntisenseName="ypdP" /AntisenseCor="-0.65324924042743404" /AntisenseRegPval="-33.4" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="0.92, 0.564" /TUlongSig="NA" /TUlongPSig="NA" /label="S830" promotor_-35 1908591..1908596 /Source="Nicolas_upshift_promotors" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1908609..1908628 /Source="Nicolas_upshift_promotors" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1908614 /Source="Nicolas_upshifts" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="upshifts" CDS 1908657..1909346 /gene="queP" /locus_tag="BSU_21980" /old_locus_tag="BSU21980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 28208705; Product type t : transporter" /codon_start=1 /transl_table=11 /product="preQ0 transporter (promiscuous)" /protein_id="NP_390081.1" /db_xref="EnsemblGenomes-Gn:BSU21980" /db_xref="EnsemblGenomes-Tr:CAB14116" /db_xref="GOA:P54163" /db_xref="InterPro:IPR003744" /db_xref="SubtiList:BG11607" /db_xref="UniProtKB/Swiss-Prot:P54163" /translation="MFNNSFWIFFAIIHFIIVLLFYKGFGKMGLFVWIGFATVCANLQ VVKTVELFGLTATLGNVMYGTIFFATDVLNEKYGPAEARKAVWLGFSTLLTLTFVMQG VLLFEPASSDISQTALETIFGFLPRVALGSLLAFIFSQTLDVYVYSAIRRIFPSDRLL WLRNGGSTAVSQLFDTFIFTAVAFLGIYPADVWLHIFISTYLIKFAVSLISLPYAYAA KKMIPNDERSS*" /label="queP CDS" gene 1908657..1909346 /gene="queP" /locus_tag="BSU_21980" /old_locus_tag="BSU21980" /label="queP gene" promotor_-35 complement(1908710..1908726) /Source="Nicolas_upshift_promotors" /id="U1723" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.92007992007992" /xcortree=644 /SigmaFactorBS="gactgtcgcaaaaccgatccaaacaaacagtcccattttgcc aaatcCTTTATAAAATAAAAGAacAatgataaaatgaatgatcgcaaaaaagatccaa a" /listShort="S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1908713) /Source="Nicolas_upshifts" /id="U1723" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.92007992007992" /xcortree=644 /SigmaFactorBS="gactgtcgcaaaaccgatccaaacaaacagtcccattttgcc aaatcCTTTATAAAATAAAAGAacAatgataaaatgaatgatcgcaaaaaagatccaa a" /listShort="S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1908714..1909103) /Source="Nicolas_S_feature" /locus_tag="new_2309787_2310176_c" /HighExp="S5, S4, S6, S7, S8, T5.0H, S3, T4.0H, BT, M9-stat" /AntisenseName="ypdP" /AntisenseCor="-0.645700204826543" /AntisenseRegPval="-32.4" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig="0.564" /TUlongSig="NA" /TUlongPSig="NA" /label="S831" promotor_-10 complement(1909084..1909103) /Source="Nicolas_upshift_promotors" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1909101) /Source="Nicolas_upshifts" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1909115..1909123) /Source="Nicolas_upshift_promotors" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1909346..1909744 /gene="ypdQ" /locus_tag="BSU_21990" /old_locus_tag="BSU21990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9888800, 10094689, 15115438, 17905985; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding protein (no RNase H activity)" /protein_id="NP_390082.1" /db_xref="EnsemblGenomes-Gn:BSU21990" /db_xref="EnsemblGenomes-Tr:CAB14117" /db_xref="GOA:P54162" /db_xref="InterPro:IPR002156" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11608" /db_xref="UniProtKB/Swiss-Prot:P54162" /translation="MPTEIYVDGASAGNPGPSGIGIFIKHEGKAESFSIPIGVHTNQE AEFLALIEGMKLCATRGYQSVSFRTDSDIVERATELEMVKNITFQPFVEEIIRLKAAF PLFFIKWIPGKQNQKADLLAKEAIRLNEKN*" /label="ypdQ CDS" gene 1909346..1909744 /gene="ypdQ" /locus_tag="BSU_21990" /old_locus_tag="BSU21990" /label="ypdQ gene" promotor_-35 1909737..1909743 /Source="Nicolas_upshift_promotors" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1909758..1909769 /Source="Nicolas_upshift_promotors" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1909769 /Source="Nicolas_upshifts" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="upshifts" CDS 1909786..1909914 /gene="sspL" /locus_tag="BSU_22000" /old_locus_tag="BSU22000" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054584.1" /db_xref="EnsemblGenomes-Gn:BSU22000" /db_xref="EnsemblGenomes-Tr:CAE01458" /db_xref="GOA:Q7WY66" /db_xref="InterPro:IPR017526" /db_xref="SubtiList:BG14176" /db_xref="UniProtKB/Swiss-Prot:Q7WY66" /translation="MKKKDKGRLTGGVTPQGDLEGNTHNDPKTELEERAKKSNTKR*" /label="sspL CDS" gene 1909786..1909914 /gene="sspL" /locus_tag="BSU_22000" /old_locus_tag="BSU22000" /label="sspL gene" S_feature 1909915..1910895 /Source="Nicolas_S_feature" /locus_tag="new_2310988_2311968" /HighExp="S8, S7, S5, S6, S4, C30, nit, ferm, Pyr, S3" /AntisenseName="exoA" /AntisenseCor="-0.365099613028674" /AntisenseRegPval="-9.1999999999999993" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S832" CDS complement(1909922..1910812) /gene="exnP" /locus_tag="BSU_22010" /old_locus_tag="BSU22010" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:16045613, 17038322, 17905985, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16045613, 17038322, 17905985, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5'3'-exonuclease" /protein_id="NP_390083.1" /db_xref="EnsemblGenomes-Gn:BSU22010" /db_xref="EnsemblGenomes-Tr:CAB14118" /db_xref="GOA:P54161" /db_xref="InterPro:IPR002421" /db_xref="InterPro:IPR008918" /db_xref="InterPro:IPR020045" /db_xref="InterPro:IPR020046" /db_xref="InterPro:IPR029060" /db_xref="InterPro:IPR036279" /db_xref="SubtiList:BG11606" /db_xref="UniProtKB/Swiss-Prot:P54161" /translation="MNNNKLLLVDGMALLFRAFFATAVHRNFMINDSGVPTNGVNGFL KHLITAVETFQPTHVVCCWDMGSKTYRNDLFQDYKANRSAPPVELIPQFDLAKEAAAE LGIMNIGFAGYEADDCIGTLADLFANEADITVVTGDRDLLQLLTDKVSVALLQKGIGN YKVYTKETFYEETGVMPKALIDIKALMGDSSDNYPGVKGIGEKTAYKLIREYETIDRL LENLSLLPKGQQGKIQQGLSDLEMSRKLAEIHCSVPLACTLKDALFTLQMEQAADMLR RHQIKGIERMLEKLNAREIV*" /label="exnP CDS" gene complement(1909922..1910812) /gene="exnP" /locus_tag="BSU_22010" /old_locus_tag="BSU22010" /label="exnP gene" downshifts complement(1909959) /Source="Nicolas_upshifts" /id="D1152" /incds=0 /nref=10 /ntot=174 /MaxReadThrough="2.94148" /MaxDrop="4.49836" /score="3.60870815" /energy="-15.6" /TU="U1726" /idTUdmin="U1726" /TUdmin="-284" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1910834..1910853) /Source="Nicolas_upshift_promotors" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1910841) /Source="Nicolas_upshifts" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1910865..1910871) /Source="Nicolas_upshift_promotors" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1910869 /Source="Nicolas_upshifts" /id="D1153" /incds=0 /nref=4 /ntot=32 /MaxReadThrough="0.83304" /MaxDrop="4.41573" /score="0.126370352" /energy="-15" /TU="NA" /idTUdmin="U1725" /TUdmin=16 /isTUend="TRUE" /label="downshifts" CDS complement(1910913..1911059) /gene="ypzF" /locus_tag="BSU_22019" /old_locus_tag="BSU22019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097753.1" /db_xref="EnsemblGenomes-Gn:BSU22019" /db_xref="EnsemblGenomes-Tr:CAX52652" /db_xref="UniProtKB/Swiss-Prot:C0H443" /translation="MLGRTKLGNRNAQANNNAKKKNGFQTHFDSYAGREAEKLIASNK RHND*" /label="ypzF CDS" gene complement(1910913..1911059) /gene="ypzF" /locus_tag="BSU_22019" /old_locus_tag="BSU22019" /label="ypzF gene" downshifts complement(1910929) /Source="Nicolas_upshifts" /id="D1154" /incds=0 /nref=253 /ntot=272 /MaxReadThrough="0.89691" /MaxDrop="8.47168" /score="25.632979" /energy="-12" /TU="NA" /idTUdmin="U1727" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1911083) /Source="Nicolas_upshifts" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1911084..1911095) /Source="Nicolas_upshift_promotors" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1911110..1911116) /Source="Nicolas_upshift_promotors" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1911134..1911391) /gene="ypbS" /locus_tag="BSU_22020" /old_locus_tag="BSU22020" /experiment="publication(s) with functional evidences, PMID:20709900, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20709900, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore associated protein" /protein_id="NP_390084.1" /db_xref="EnsemblGenomes-Gn:BSU22020" /db_xref="EnsemblGenomes-Tr:CAB14119" /db_xref="InterPro:IPR019688" /db_xref="SubtiList:BG11605" /db_xref="UniProtKB/Swiss-Prot:P54160" /translation="MSEVHKAISAHSSKQHEHIKAFMRLENMRELAIEEAVAKCRNDE PYTTDAINEITEQMNQLAKKGIVPTRRLVSKEMVREYVSRM*" /label="ypbS CDS" gene complement(1911134..1911391) /gene="ypbS" /locus_tag="BSU_22020" /old_locus_tag="BSU22020" /label="ypbS gene" promotor_-10 complement(1911411..1911430) /Source="Nicolas_upshift_promotors" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1911426) /Source="Nicolas_upshifts" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1911442..1911449) /Source="Nicolas_upshift_promotors" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1911456..1915037) /gene="dynA" /locus_tag="BSU_22030" /old_locus_tag="BSU22030" /EC_number="3.6.5.5" /experiment="publication(s) with functional evidences, PMID:21205012, 23388828, 23249255, 26842743, 26530236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21205012, 23388828, 23249255, 26842743, 26530236; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dynamin GTPase" /protein_id="NP_390085.1" /db_xref="EnsemblGenomes-Gn:BSU22030" /db_xref="EnsemblGenomes-Tr:CAB14120" /db_xref="GOA:P54159" /db_xref="InterPro:IPR022812" /db_xref="InterPro:IPR027094" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11604" /db_xref="UniProtKB/Swiss-Prot:P54159" /translation="MTDQNRKELLHKTGELYKQFIENQDEQRAAKLAAVMKKAADEEV YIAFTGHYSAGKSSLLNCLLMENILPTSPIPTSANLVVIRNGEKRVRLHTTDGACAEL EGTYQKDKVQQYCKDGEQIESVEIFDRYTEIDSGVAYIDTPGIDSTDDAHFLSAASIL HQADALFYVVHYNHVHAEENVKFLRSIKESIPNVYFIVNQIDRHDETETKFGDYQAQV EEMLCNEGISREALYFTSVTEPDHPFNQMGALREELSRIEQQSKSNMQALTEQKVRNL LKEHTEMLKKDETGAPSFAEQLNIHTGLVQSLRDQLDEAEKQMTEAEKRMQEEINRIL KNANLTPFEMRELAAAFLESQEPSFKTGFFFSKAKTAQERDKRRNAFFSDVAKRTEAE ADWHMIDTLHKLAKVFDVYTAESEKLIQAYRTPLDISIIEHAVKHGAAFSSEYVLQYT KDLAELIRKEAKREAADIIKVLSAMVKERVSKDVQTINDRLVQESEKLVFLQEQARLE NNAREKTDRLWAIWEEESACPMHIDTEWFKSKKTRVAAPEQKQGRSQLTAQPMPKSEI KMEQEMPLQDQIKRFYTLSDILGECSMLLKQTSAFRERVKRLEERKFTLALFGGFSSG KSSFANALVGERVLPSSPTPTTATINKITKPINGNLNKTANVVFKTEDDLTAEILQLT GIPKEPAGRSFTEKWEKAVKKNRLQEEHVKLISNFLLAYEKYQQYIQEQKKLTIPLSE LKPYVAEETTACAVKEVTVYYTCPLTEKGITIVDTPGASSMNKRHTELAFQYIKDADA FFYMTYYQHSFSKGDRSFLRKLGLVKESLSMDKMFFIINAADLAKDKTELETVTDYVS AELVKEGVYEPQLFTVSSKEELVGKPESFYNQFSKVRKHLDRFIEVDVKKASAAQLSS EADKLCETVFQLHQSQHQSREEKEAQKQCLMLSFERTAADIEKRRNSKTIIEKVKKDT REQLYHIAQRLSYFANDLLKSAFHPGLQNGDWKKNVSKAMTTALHEYLFEYIQEIKTL DVRMSGFIERHINEEWLDHFQKTLNEDGYFSVYAGDQHSNGIQLKEVEPEIEERAFEQ ELKEIKSPKQFFEQKGKATFIEAVRMKLTKITEAWIKNEEESLISHYTAHLRRLQEDM GEKAIAQITDQKETYLRGYAEGEHAKEIEMAYQACISWKNSDNTIKM*" /label="dynA CDS" gene complement(1911456..1915037) /gene="dynA" /locus_tag="BSU_22030" /old_locus_tag="BSU22030" /label="dynA gene" S_feature complement(1915038..1915109) /Source="Nicolas_S_feature" /locus_tag="new_2316111_2316182_c" /HighExp="LBGstat, T1.30H, T1.0H, BMM, T2.30H, M9-stat, MG 150, T0.30H, T2.0H, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S833" misc_feature complement(1915099..1915118) /Source="Nicolas_upshift_promotors" /id="U1729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.987012987012987" /xcortree=2239 /SigmaFactorBS="gctgccgtaatggcggcttttttctattctcctaaagaaatt tggtttattCTTGTGTAAAATGAAAAGGGaatgaattcagatctttcgaaaaaggttc a" /listShort="S833, ypbR" /listLong="ypbS, ypzF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1915109) /Source="Nicolas_upshifts" /id="U1729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.987012987012987" /xcortree=2239 /SigmaFactorBS="gctgccgtaatggcggcttttttctattctcctaaagaaatt tggtttattCTTGTGTAAAATGAAAAGGGaatgaattcagatctttcgaaaaaggttc a" /listShort="S833, ypbR" /listLong="ypbS, ypzF" /label="upshifts" S_feature complement(1915154..1915351) /Source="Nicolas_S_feature" /locus_tag="new_2316227_2316424_c" /HighExp="HiOs, B60, GM 25, S7, GM 15, B36, S5, S8, GM 5, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.24118200000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S834" downshifts complement(1915197) /Source="Nicolas_upshifts" /id="D1155" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="3.11615" /MaxDrop="3.46525" /score="27.1937922" /energy="-9.7" /TU="U1730" /idTUdmin="U1730" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1915213..1915302) /gene="fbpC" /locus_tag="BSU_22036" /old_locus_tag="BSU22036" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18697947, 22389480, 22427629" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947, 22389480, 22427629; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="YP_009513974.1" /db_xref="EnsemblGenomes-Gn:BSU22036" /db_xref="EnsemblGenomes-Tr:CCQ48599" /db_xref="UniProtKB/TrEMBL:L8ECR0" /translation="MTMLFLLGAVCTYSVLIGFVLKGISNKSV*" /label="fbpC CDS" gene complement(1915213..1915302) /gene="fbpC" /locus_tag="BSU_22036" /old_locus_tag="BSU22036" /label="fbpC gene" promotor_-10 complement(1915330..1915349) /Source="Nicolas_upshift_promotors" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1915351) /Source="Nicolas_upshifts" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1915364..1915371) /Source="Nicolas_upshift_promotors" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1915373..1915879) /gene="bpsB" /locus_tag="BSU_22040" /old_locus_tag="BSU22040" /EC_number="2.1.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16850406, 7726551, 8396117, 19465653" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16850406, 7726551, 8396117, 19465653; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alkylpyrone methyltransferase (polyketide synthesis)" /protein_id="NP_390086.1" /db_xref="EnsemblGenomes-Gn:BSU22040" /db_xref="EnsemblGenomes-Tr:CAB14121" /db_xref="GOA:P54158" /db_xref="InterPro:IPR007269" /db_xref="SubtiList:BG11603" /db_xref="UniProtKB/Swiss-Prot:P54158" /translation="MFWLLIAILIVQRAAEMAVARQNEQKVKKQGAIEFGESHYPYII TMHILFFLSLIAEVLLMNKQPSSWWLGIAAVILSVQIVRYWALCSLGAYWNTKILVVP GVELVKKGPYKWMKHPNYAVVILEILLIPLLYQAYVTMCLFSIFNAVLLSVRIRAEDK ALQEYSVK*" /label="bpsB CDS" gene complement(1915373..1915879) /gene="bpsB" /locus_tag="BSU_22040" /old_locus_tag="BSU22040" /label="bpsB gene" CDS complement(1915883..1916980) /gene="bpsA" /locus_tag="BSU_22050" /old_locus_tag="BSU22050" /EC_number="2.3.1.-" /function="15.10: Adaptations to atypical conditions" /experiment="publication(s) with functional evidences, PMID:19465653" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19465653; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous alkylpyrone synthase BpsA (polyketide synthesis)" /protein_id="NP_390087.1" /db_xref="EnsemblGenomes-Gn:BSU22050" /db_xref="EnsemblGenomes-Tr:CAB14122" /db_xref="GOA:P54157" /db_xref="InterPro:IPR001099" /db_xref="InterPro:IPR011141" /db_xref="InterPro:IPR012328" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR018088" /db_xref="SubtiList:BG11523" /db_xref="UniProtKB/Swiss-Prot:P54157" /translation="MAFILSIGTSLPAYNVNQEKAAEFARYMFQHSFKDIDRLLSSFK NGQIHSRQFVKPIEWYKEGHSFEEKNQIYIEETLKHSRAAVRECLSHPEFFQEAIPYE KVEAVFFVSSTGLSTPSIEARLMNELPFSPYTKRIPIWGLGCAGGASGLARAAEYCKA YPEAFVLVISAELCSLTFQPEDKTKSNLIGTSLFGDGIAAALLCGEKADRRVSKLKLA PKIMDAQSVLMKQSEDVMGWDFTDQGFKVIFSRDIPTLVEKWLKTNVQIFLDKHKLSF HDISVFLAHPGGKKVIDAYIKSLGLSSEKLSSAQSILQKHGNMSSATILYVIKDHLQN GHKKEAERGLIGALGPGFSSELLLFSWEKGA*" /label="bpsA CDS" gene complement(1915883..1916980) /gene="bpsA" /locus_tag="BSU_22050" /old_locus_tag="BSU22050" /label="bpsA gene" promotor_-10 complement(1916998..1917009) /Source="Nicolas_upshift_promotors" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1917001) /Source="Nicolas_upshifts" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1917024..1917030) /Source="Nicolas_upshift_promotors" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1917054..1918370) /gene="pbuX" /locus_tag="BSU_22060" /old_locus_tag="BSU22060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098051, 12923093, 15549109, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098051, 12923093, 15549109, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xanthine permease" /protein_id="NP_390088.1" /db_xref="EnsemblGenomes-Gn:BSU22060" /db_xref="EnsemblGenomes-Tr:CAB14123" /db_xref="GOA:P42086" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG11080" /db_xref="UniProtKB/Swiss-Prot:P42086" /translation="MRNGFGKTLSLGIQHVLAMYAGAIVVPLIVGKAMGLTVEQLTYL VSIDIFMCGVATLLQVWSNRFFGIGLPVVLGCTFTAVSPMIAIGSEYGVSTVYGSIIA SGILVILISFFFGKLVSFFPPVVTGSVVTIIGITLMPVAMNNMAGGEGSADFGDLSNL ALAFTVLSIIVLLYRFTKGFIKSVSILIGILIGTFIAYFMGKVQFDNVSDAAVVQMIQ PFYFGAPSFHAAPIITMSIVAIVSLVESTGVYFALGDLTNRRLTEIDLSKGYRAEGLA VLLGGIFNAFPYTAFSQNVGLVQLTGIKKNAVIVVTGVILMAFGLFPKIAAFTTIIPS AVLGGAMVAMFGMVIAYGIKMLSRIDFAKQENLLIVACSVGLGLGVTVVPDIFKQLPS ALTLLTTNGIVAGSFTAVVLNIVYNVFSKAKKIEQEADLAEQKTAV*" /label="pbuX CDS" gene complement(1917054..1918370) /gene="pbuX" /locus_tag="BSU_22060" /old_locus_tag="BSU22060" /label="pbuX gene" downshifts complement(1917067) /Source="Nicolas_upshifts" /id="D1156" /incds=0 /nref=177 /ntot=215 /MaxReadThrough="1.81377" /MaxDrop="6.3089" /score="32.8866099" /energy="-9" /TU="U1733" /idTUdmin="U1732" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1918367..1918951) /gene="xpt" /locus_tag="BSU_22070" /old_locus_tag="BSU22070" /EC_number="2.4.2.22" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12923093, 15549109, 19381559, 20108980, 20200045" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12923093, 15549109, 19381559, 20108980, 20200045; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine phosphoribosyltransferase" /protein_id="NP_390089.1" /db_xref="EnsemblGenomes-Gn:BSU22070" /db_xref="EnsemblGenomes-Tr:CAB14124" /db_xref="GOA:P42085" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR010079" /db_xref="InterPro:IPR029057" /db_xref="PDB:1Y0B" /db_xref="PDB:2FXV" /db_xref="SubtiList:BG11079" /db_xref="UniProtKB/Swiss-Prot:P42085" /translation="MEALKRKIEEEGVVLSDQVLKVDSFLNHQIDPLLMQRIGDEFAS RFAKDGITKIVTIESSGIAPAVMTGLKLGVPVVFARKHKSLTLTDNLLTASVYSFTKQ TESQIAVSGTHLSDQDHVLIIDDFLANGQAAHGLVSIVKQAGASIAGIGIVIEKSFQP GRDELVKLGYRVESLARIQSLEEGKVSFVQEVHS*" /label="xpt CDS" gene complement(1918367..1918951) /gene="xpt" /locus_tag="BSU_22070" /old_locus_tag="BSU22070" /label="xpt gene" misc_RNA complement(1919040..1919140) /gene="gswA" /locus_tag="BSU_misc_RNA_34" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477; Product type n: RNA" /label="gswA RNA" gene complement(1919040..1919140) /gene="gswA" /locus_tag="BSU_misc_RNA_34" /label="gswA gene" downshifts complement(1919047) /Source="Nicolas_upshifts" /id="D1157" /incds=0 /nref=8 /ntot=35 /MaxReadThrough="6.97435" /MaxDrop="3.25" /score="36.5247418" /energy="-19.2" /TU="U1732,U1733" /idTUdmin="U1734" /TUdmin=1870 /isTUend="FALSE" /label="downshifts" S_feature complement(1919141..1919281) /Source="Nicolas_S_feature" /locus_tag="new_2320214_2320354_c" /HighExp="dia15, BT, dia5, Diami, C90, LBGtran, Lbtran, Gly, SMMPr, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.291, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S835" CDS complement(1919282..1920787) /gene="ypwA" /locus_tag="BSU_22080" /old_locus_tag="BSU22080" /EC_number="3.4.17.19" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7765282, 22730127; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="metal-dependent carboxypeptidase" /protein_id="NP_390090.1" /db_xref="EnsemblGenomes-Gn:BSU22080" /db_xref="EnsemblGenomes-Tr:CAB14125" /db_xref="GOA:P50848" /db_xref="InterPro:IPR001333" /db_xref="PDB:3HQ2" /db_xref="SubtiList:BG11458" /db_xref="UniProtKB/Swiss-Prot:P50848" /translation="MEIHTYEKEFFDLLKRISHYSEAVALMHWDSRTGAPKNGSEDRA ESIGQLSTDIFNIQTSDRMKELIDVLYERFDDLSEDTKKAVELAKKEYEENKKIPEAE YKEYVILCSKAETAWEEAKGKSDFSLFSPYLEQLIEFNKRFITYWGYQEHPYDALLDL FEPGVTVKVLDQLFAELKEAIIPLVKQVTASGNKPDTSFITKAFPKEKQKELSLYFLQ ELGYDFDGGRLDETVHPFATTLNRGDVRVTTRYDEKDFRTAIFGTIHECGHAIYEQNI DEALSGTNLSDGASMGIHESQSLFYENFIGRNKHFWTPYYKKIQEASPVQFKDISLDD FVRAINESKPSFIRVEADELTYPLHIIIRYEIEKAIFSNEVSVEDLPSLWNQKYQDYL GITPQTDAEGILQDVHWAGGDFGYFPSYALGYMYAAQLKQKMLEDLPEFDALLERGEF HPIKQWLTEKVHIHGKRKKPLDIIKDATGEELNVRYLIDYLSNKYSNLYLL*" /label="ypwA CDS" gene complement(1919282..1920787) /gene="ypwA" /locus_tag="BSU_22080" /old_locus_tag="BSU22080" /label="ypwA gene" promotor_no_box complement(1920723..1920823) /Source="Nicolas_upshift_promotors" /id="U1732" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.290709290709291" /xcortree=1802 /SigmaFactorBS="ctgtaatggaacggctagaatagggagggaatggatatggag atacatacatatgaaaaagaattttttgatcttttaaaaagaatctcacattacagcg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1920763) /Source="Nicolas_upshifts" /id="U1732" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.290709290709291" /xcortree=1802 /SigmaFactorBS="ctgtaatggaacggctagaatagggagggaatggatatggag atacatacatatgaaaaagaattttttgatcttttaaaaagaatctcacattacagcg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="upshifts" downshifts 1920775 /Source="Nicolas_upshifts" /id="D1158" /incds=0 /nref=4 /ntot=78 /MaxReadThrough="1.34397" /MaxDrop="3.87399" /score="12.6922524" /energy="-13.3" /TU="NA" /idTUdmin="U1735" /TUdmin="-5588" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1920813..1920832) /Source="Nicolas_upshift_promotors" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1920829) /Source="Nicolas_upshifts" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1920846..1920853) /Source="Nicolas_upshift_promotors" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1920899..1921891) /gene="kdgT" /locus_tag="BSU_22090" /old_locus_tag="BSU22090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 9846747; Product type t: transporter" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate permease" /protein_id="NP_390091.1" /db_xref="EnsemblGenomes-Gn:BSU22090" /db_xref="EnsemblGenomes-Tr:CAB14126" /db_xref="GOA:P50847" /db_xref="InterPro:IPR004684" /db_xref="InterPro:IPR018395" /db_xref="SubtiList:BG11399" /db_xref="UniProtKB/Swiss-Prot:P50847" /translation="MKIKATIERVPGGMMIIPLFLGAALNTFAPGTAEFFGGFTGALI TGTLPILGVFIFCVGATIDFRSSGYIARKGITLLLGKIGFAALLGVIAAQFIPDDGIQ SGFFAGLSVLAIVAVMNETNGGLYLALMNHMGRKEDAGAFAFISTESGPFMTMVTFGV TGLAAFPWETLAATVIPFLLGCILGNLDHDLRDLFSKVVPAIIPFFAFSLGNTLNFGM LIQSGLLGIFIGVSVVILSGSSLFLLDRFIARGDGVAGVAASSTAGAAVAVPYALAEA NASFAPVAESATAIIATSVIVTSLLTPLATVWVDKKIKQKKRRTPPPKNQMTIN*" /label="kdgT CDS" gene complement(1920899..1921891) /gene="kdgT" /locus_tag="BSU_22090" /old_locus_tag="BSU22090" /label="kdgT gene" downshifts complement(1920917) /Source="Nicolas_upshifts" /id="D1159" /incds=0 /nref=15 /ntot=59 /MaxReadThrough="3.32882" /MaxDrop="5.85236" /score="36.5247418" /energy="-19.2" /TU="NA" /idTUdmin="U1734" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1921936..1922526) /gene="kdgA" /locus_tag="BSU_22100" /old_locus_tag="BSU22100" /EC_number="4.1.2.14" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9846747, 10368143; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate-6-phosphate aldolase" /protein_id="NP_390092.1" /db_xref="EnsemblGenomes-Gn:BSU22100" /db_xref="EnsemblGenomes-Tr:CAB14127" /db_xref="GOA:P50846" /db_xref="InterPro:IPR000887" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR031338" /db_xref="SubtiList:BG11396" /db_xref="UniProtKB/Swiss-Prot:P50846" /translation="MESKVVENRLKEAKLIAVIRSKDKQEACQQIESLLDKGIRAVEV TYTTPGASDIIESFRNREDILIGAGTVISAQQAGEAAKAGAQFIVSPGFSADLAEHLS FVKTHYIPGVLTPSEIMEALTFGFTTLKLFPSGVFGIPFMKNLAGPFPQVTFIPTGGI HPSEVPDWLRAGAGAVGVGSQLGSCSKEDLQAVFQV*" /label="kdgA CDS" gene complement(1921936..1922526) /gene="kdgA" /locus_tag="BSU_22100" /old_locus_tag="BSU22100" /label="kdgA gene" CDS complement(1922528..1923502) /gene="kdgK" /locus_tag="BSU_22110" /old_locus_tag="BSU22110" /EC_number="2.7.1.45" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9846747, 10368143, 15039578; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate kinase" /protein_id="NP_390093.1" /db_xref="EnsemblGenomes-Gn:BSU22110" /db_xref="EnsemblGenomes-Tr:CAB14128" /db_xref="GOA:P50845" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG11397" /db_xref="UniProtKB/Swiss-Prot:P50845" /translation="MKLDAVTFGESMAMFYANEYGGLHEVSTFSKGLAGAESNVACGL ARLGFRMGWMSKVGNDQLGTFILQELKKEGVDVSRVIRSQDENPTGLLLKSKVKEGDP QVTYYRKNSAASTLTTAEYPRDYFQCAGHLHVTGIPPALSAEMKDFTYHVMNDMRNAG KTISFDPNVRPSLWPDQATMVHTINDLAGLADWFFPGIAEGELLTGEKTPEGIADYYL KKGASFVAIKLGKEGAYFKTGTSEGFLEGCRVDRVVDTVGAGDGFAVGVISGILDGLS YKDAVQRGNAIGALQVQAPGDMDGLPTREKLASFLSAQRTVHQKKGDY*" /label="kdgK CDS" gene complement(1922528..1923502) /gene="kdgK" /locus_tag="BSU_22110" /old_locus_tag="BSU22110" /label="kdgK gene" CDS complement(1923540..1924559) /gene="kdgR" /locus_tag="BSU_22120" /old_locus_tag="BSU22120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9846747, 15223311, 17322190, 28040177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9846747, 15223311, 17322190, 28040177; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the Kdg operon (KdgR-galacturonate)" /protein_id="NP_390094.1" /db_xref="EnsemblGenomes-Gn:BSU22120" /db_xref="EnsemblGenomes-Tr:CAB14129" /db_xref="GOA:P50844" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR012310" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG11398" /db_xref="UniProtKB/Swiss-Prot:P50844" /translation="MKKKTTGHTTIKDVAECAGVSKSTVSRYINGKIDAISPEKVKNI KKAIAELNYRPSKMAQGLKIKKSKLIGFVVADITNPFSVAAFRGVEEVCDQYGYSIMV CNTDNSPEKEREMLLKLEAHSVEGLILNATGENKDVLRAFAEQQIPTILIDRKLPDLK LDTVTTDNRWITKEILQKVYSKGYTDVALFTEPISSISPRAERAAVYQEMASVQNVNG LVRLHEIDVKDKEQLKAELRSFHKEMPEQKKAILALNGLIMLKIISCMEELGLRIPQD IGIAGFDDTEWYKLIGPGITTIAQPSHDMGRTAMERVLKRIEGDKGAPQTIELEAKVI MRKSL*" /label="kdgR CDS" gene complement(1923540..1924559) /gene="kdgR" /locus_tag="BSU_22120" /old_locus_tag="BSU22120" /label="kdgR gene" promotor_-10 complement(1924607..1924626) /Source="Nicolas_upshift_promotors" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1924617) /Source="Nicolas_upshifts" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1924638..1924645) /Source="Nicolas_upshift_promotors" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1924680..1924687 /Source="Nicolas_upshift_promotors" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1924701..1924780 /Source="Nicolas_S_feature" /locus_tag="new_2325774_2325853" /HighExp="HiTm, Heat, nit, LBGstat, ferm, T-0.40H, HiOs, T1.30H, MG 150, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S836" upshifts 1924701 /Source="Nicolas_upshifts" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1924702..1924721 /Source="Nicolas_upshift_promotors" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1924781..1925608 /gene="kduI" /locus_tag="BSU_22130" /old_locus_tag="BSU22130" /EC_number="5.3.1.17" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15528647, 23437267, 27227414; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase, 5-keto-4-deoxyuronate isomerase" /protein_id="NP_390095.1" /db_xref="EnsemblGenomes-Gn:BSU22130" /db_xref="EnsemblGenomes-Tr:CAB14130" /db_xref="GOA:P50843" /db_xref="InterPro:IPR007045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR021120" /db_xref="InterPro:IPR027449" /db_xref="SubtiList:BG11401" /db_xref="UniProtKB/Swiss-Prot:P50843" /translation="MENRYSVHPEQVKRFTTEELRSHFLMDSLFTENKLTMYYSHEDR VVIGGAAPGQSELKLDAGDFLKTDFFLERREIGIINVGQPGAVRVGDDEYVLQTKDFL YIGMGNQDVSFSSLNGEKAKFYFVSACAHKSYPTQKAALSELTPDRLGDDAASNVRSL YKVIHQDGIKSCQLMMGITMLDQNNNWNTMPAHVHDRRMEAYLYLDLEKDSKVFHFMG QPDETRHLVVGNEQAVLSPAWSIHSGAGTSNYSFVWAMAGENYTFTDMDLIPMDGLK* " /label="kduI CDS" gene 1924781..1925608 /gene="kduI" /locus_tag="BSU_22130" /old_locus_tag="BSU22130" /label="kduI gene" CDS 1925610..1926374 /gene="kduD" /locus_tag="BSU_22140" /old_locus_tag="BSU22140" /EC_number="1.1.1.127" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15528647, 24509771, 27028675; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate oxidoreductase" /protein_id="NP_390096.1" /db_xref="EnsemblGenomes-Gn:BSU22140" /db_xref="EnsemblGenomes-Tr:CAB14131" /db_xref="GOA:P50842" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011286" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11400" /db_xref="UniProtKB/Swiss-Prot:P50842" /translation="MGYLHDAFSLKGKTALVTGPGTGIGQGIAKALAGAGADIIGTSH TSSLSETQQLVEQEGRIFTSFTLDMSKPEAIKDSAAELFENRQIDILVNNAGIIHREK AEDFPEENWQHVLNVNLNSLFILTQLAGRHMLKRGHGKIINIASLLSFQGGILVPAYT ASKHAVAGLTKSFANEWAASGIQVNAIAPGYISTANTKPIRDDEKRNEDILKRIPAGR WGQADDIGGTAVFLASRASDYVNGHILAVDGGWLSR*" /label="kduD CDS" gene 1925610..1926374 /gene="kduD" /locus_tag="BSU_22140" /old_locus_tag="BSU22140" /label="kduD gene" downshifts 1926363 /Source="Nicolas_upshifts" /id="D1160" /incds=0 /nref=12 /ntot=160 /MaxReadThrough="0.66029" /MaxDrop="3.56178" /score="23.0070487" /energy="-12.3" /TU="NA" /idTUdmin="U1735" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1926405) /Source="Nicolas_upshifts" /id="D1161" /incds=0 /nref=28 /ntot=225 /MaxReadThrough="1.88107" /MaxDrop="5.27501" /score="35.5168663" /energy="-12.3" /TU="NA" /idTUdmin="U1736" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(1926415..1928340) /gene="ypvA" /locus_tag="BSU_22150" /old_locus_tag="BSU22150" /EC_number="3.6.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8385320, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent helicase" /protein_id="NP_390097.1" /db_xref="EnsemblGenomes-Gn:BSU22150" /db_xref="EnsemblGenomes-Tr:CAB14132" /db_xref="GOA:P50831" /db_xref="InterPro:IPR006555" /db_xref="InterPro:IPR014013" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11457" /db_xref="UniProtKB/Swiss-Prot:P50831" /translation="MTTSRLPFSLTKTKNFYEELNNWIGDVFYDILPEKGFDLRDEQV FMAFQLERAFKEKKVMFAEAGVGTGKTLVYLLFAISYARYVGKPAIIACADETLIEQL VKKEGDISKLAEHLDLKIDTRLSKSHEQYLCLKKLEKTMQRSDDDKWLDLYESLPSFV HESQAMQRFYPYGDRKQYANLSNEEWSDVSYDSFQDCLTCDMRHRCGLTLSRDYYRKS TDLIICSHDFYMEHVWTEESRKREGQLPLLPDHSAVVFDEGHLLEFAAQKALTYRVKQ STLELFLERLLQNDIREEFAELIEDALLANDEFFYVLSEESKEVAGSHRLEIKNDHRV KKAADELCRLLDKIGEALVFESEMYTIDQYELSVVEEYVEQMAYSLSLYQKDAISWLE KKEAESTFVVMPRTVAEVLGEKVFSKKIPYIFSSATLSEGGSFDYIADSLGIHDYLSL TVDSPYDYDEQMSINLYAKTDMDAEQKTAETIETIKRYKGRTLVLFPSFEELNEFKEL SAAWELPYPIFFEGDEEISSLVEKFQEEEETVLCSVHLWEGLDIPGDALKNVTIWSLP FPPHDPVFTAKRNGAKKDPFEEVDLPYMLLRVRQGIGRLIRSNQDSGSIHIYAGGENE RIIDEVKKVLPVEPHMM*" /label="ypvA CDS" gene complement(1926415..1928340) /gene="ypvA" /locus_tag="BSU_22150" /old_locus_tag="BSU22150" /label="ypvA gene" promotor_-10 complement(1928371..1928390) /Source="Nicolas_upshift_promotors" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1928375) /Source="Nicolas_upshifts" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1928377..1928441) /Source="Nicolas_S_feature" /locus_tag="new_2329450_2329514_c" /HighExp="S3, S4, S8, S7, LoTm, S5, S6, BT, G180, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 1, 0.998, 1" /label="S837" promotor_-35 complement(1928405..1928409) /Source="Nicolas_upshift_promotors" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1928442..1928633) /gene="yptA" /locus_tag="BSU_22160" /old_locus_tag="BSU22160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390098.1" /db_xref="EnsemblGenomes-Gn:BSU22160" /db_xref="EnsemblGenomes-Tr:CAB14133" /db_xref="SubtiList:BG11456" /db_xref="UniProtKB/Swiss-Prot:P50841" /translation="MLNSEHFNLIQRALDATANELKELGTDSSPSVISHAQTDLEKAV EHIYSTDHPFLSSHVINRK*" /label="yptA CDS" gene complement(1928442..1928633) /gene="yptA" /locus_tag="BSU_22160" /old_locus_tag="BSU22160" /label="yptA gene" promotor_-10 complement(1928652..1928670) /Source="Nicolas_upshift_promotors" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1928661) /Source="Nicolas_upshifts" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1928663..1928968) /Source="Nicolas_S_feature" /locus_tag="new_2329736_2330041_c" /HighExp="Cold, G135, G180, C30, G150, Oxctl, Paraq, H2O2, LBGstat, LPh" /AntisenseName="ypzG" /AntisenseCor="-0.39420155633160697" /AntisenseRegPval="-10.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 1, 0.998, 1" /label="S838" promotor_-35 complement(1928686..1928691) /Source="Nicolas_upshift_promotors" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1928700..1928706 /Source="Nicolas_upshift_promotors" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1928721..1928732 /Source="Nicolas_upshift_promotors" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1928730 /Source="Nicolas_upshifts" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="upshifts" CDS 1928797..1928949 /gene="ypzG" /locus_tag="BSU_22169" /old_locus_tag="BSU22169" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097754.1" /db_xref="EnsemblGenomes-Gn:BSU22169" /db_xref="EnsemblGenomes-Tr:CAX52653" /db_xref="InterPro:IPR025413" /db_xref="UniProtKB/Swiss-Prot:C0H444" /translation="MSYRNRLDQHSELFHHNWTRPKRSKSQVNGHTEMSQTNIILRSN AKAHRW*" /label="ypzG CDS" gene 1928797..1928949 /gene="ypzG" /locus_tag="BSU_22169" /old_locus_tag="BSU22169" /label="ypzG gene" downshifts 1928959 /Source="Nicolas_upshifts" /id="D1162" /incds=0 /nref=35 /ntot=65 /MaxReadThrough="1.2837" /MaxDrop="7.64655" /score="-9.36260071" /energy="-16.3" /TU="NA" /idTUdmin="U1738" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1929002..1930159) /gene="rlmKB" /locus_tag="BSU_22170" /old_locus_tag="BSU22170" /EC_number="2.1.1.264" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22210896, 22362734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="m(7)G2069 methylase of 23S rRNA" /protein_id="NP_390099.1" /db_xref="EnsemblGenomes-Gn:BSU22170" /db_xref="EnsemblGenomes-Tr:CAB14134" /db_xref="GOA:P50840" /db_xref="InterPro:IPR000241" /db_xref="InterPro:IPR002052" /db_xref="InterPro:IPR004114" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11455" /db_xref="UniProtKB/Swiss-Prot:P50840" /translation="MKKYTLIATAPMGIEAVVAKEVRDLGYECKVDNGKVIFEGDALA ICRANLWLRTADRIKVQVASFKAKTFDELFEKTKAINWRSFIPENGKFPVIGKSVKST LASVPDCQRIVKKAIVEKLKLQSGKANDWIEETGAEYKVEISLLKDQALITLDSSGTG LHKRGYRVDQGGAPIKETLAAALVQLTNWTPDRPFVDPFCGSGTIAIEAALIGQNIAP GFNRDFVSEDWEWIGKDLWNKARLEVEEKANYDQPLTIFASDIDHRMVQIAKENAEEA GLGDLIQFKQMQVKDFTTNLEFGVIVGNPPYGERLGEKKAVEQMYKEMGQAFEPLDTW SVYMLTSNENFEEAYGRKATKKRKLFNGFIKTDYYQYWSKVRPQRKKTENA*" /label="rlmKB CDS" gene complement(1929002..1930159) /gene="rlmKB" /locus_tag="BSU_22170" /old_locus_tag="BSU22170" /label="rlmKB gene" downshifts complement(1929013) /Source="Nicolas_upshifts" /id="D1163" /incds=0 /nref=86 /ntot=240 /MaxReadThrough="4.31441" /MaxDrop="4.58268" /score="14.6684819" /energy="-6.2" /TU="U1739" /idTUdmin="U1740" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA complement(1930247..1930647) /gene="rnpB" /locus_tag="BSU_misc_RNA_35" /product="RNA component of ribonuclease P (RNase P) (catalytic subunit, ribozyme)" /experiment="publication(s) with functional evidences, PMID:1699929, 16980484, 17919279, 22448220" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1699929, 16980484, 17919279, 22448220; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rnpB RNA" gene complement(1930247..1930647) /gene="rnpB" /locus_tag="BSU_misc_RNA_35" /label="rnpB gene" downshifts complement(1930257) /Source="Nicolas_upshifts" /id="D1164" /incds=0 /nref=200 /ntot=276 /MaxReadThrough="6.17541" /MaxDrop="7.4677" /score="0.20729905" /energy="-10.4" /TU="U1739,U1740" /idTUdmin="U1742" /TUdmin=406 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1930644..1930663) /Source="Nicolas_upshift_promotors" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1930662) /Source="Nicolas_upshifts" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1930678..1930684) /Source="Nicolas_upshift_promotors" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1930706..1931002) /gene="gpsB" /locus_tag="BSU_22180" /old_locus_tag="BSU22180" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:18363795, 18776011, 19429628, 25845974, 27257764" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18363795, 18776011, 19429628, 25845974, 27257764; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell division protein" /protein_id="NP_390100.1" /db_xref="EnsemblGenomes-Gn:BSU22180" /db_xref="EnsemblGenomes-Tr:CAB14135" /db_xref="GOA:P0CI74" /db_xref="InterPro:IPR007793" /db_xref="InterPro:IPR011229" /db_xref="InterPro:IPR019933" /db_xref="PDB:4UG3" /db_xref="PDB:5AN5" /db_xref="SubtiList:BG11454" /db_xref="UniProtKB/Swiss-Prot:P0CI74" /translation="MLADKVKLSAKEILEKEFKTGVRGYKQEDVDKFLDMIIKDYETF HQEIEELQQENLQLKKQLEEASKKQPVQSNTTNFDILKRLSNLEKHVFGSKLYD*" /label="gpsB CDS" gene complement(1930706..1931002) /gene="gpsB" /locus_tag="BSU_22180" /old_locus_tag="BSU22180" /label="gpsB gene" promotor_-10 complement(1931027..1931046) /Source="Nicolas_upshift_promotors" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(1931037) /Source="Nicolas_upshifts" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="upshifts" promotor_-35 complement(1931060..1931067) /Source="Nicolas_upshift_promotors" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(1931080..1931709) /gene="ypsA" /locus_tag="BSU_22190" /old_locus_tag="BSU22190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390101.2" /db_xref="EnsemblGenomes-Gn:BSU22190" /db_xref="EnsemblGenomes-Tr:CAB14136" /db_xref="InterPro:IPR010697" /db_xref="PDB:2NX2" /db_xref="SubtiList:BG11453" /db_xref="UniProtKB/Swiss-Prot:P50838" /translation="MENVQLDGVNNAAQQMGPTGAPFFKAGEMMKVLAITGYKPFELG IFKQDDKALYYIKKAIKNRLIAFLDEGLEWILISGQLGVELWAAEAAYDLQEEYPDLK VAVITPFYEQEKNWKEPNKEQYEAVLAQADYEASLTHRPYESPLQFKQKNQFFIDKSD GLLLLYDPEKEGSPKYMLGTAEKRREQDGYPIYFITMDDLRVTVEEDSY*" /label="ypsA CDS" gene complement(1931080..1931709) /gene="ypsA" /locus_tag="BSU_22190" /old_locus_tag="BSU22190" /label="ypsA gene" downshifts complement(1931675) /Source="Nicolas_upshifts" /id="D1165" /incds=0 /nref=37 /ntot=160 /MaxReadThrough="5.74028" /MaxDrop="8.12374" /score="7.18626302" /energy="-9.8" /TU="U1741,U1742" /idTUdmin="U1744" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1931711..1931938) /gene="cotD" /locus_tag="BSU_22200" /old_locus_tag="BSU22200" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:2821284, 10075739, 10400595, 1518043, 1691789, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2821284, 10075739, 10400595, 1518043, 1691789, 19933362; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (inner)" /protein_id="NP_390102.1" /db_xref="EnsemblGenomes-Gn:BSU22200" /db_xref="EnsemblGenomes-Tr:CAB14137" /db_xref="GOA:P07791" /db_xref="InterPro:IPR020108" /db_xref="SubtiList:BG10493" /db_xref="UniProtKB/Swiss-Prot:P07791" /translation="MHHCRPHMMAPIVHPTHCCEHHTFSKTIVPHIHPQHTTNVNHQH FQHVHYFPHTFSNVDPATHQHFQAGKPCCDY*" /label="cotD CDS" gene complement(1931711..1931938) /gene="cotD" /locus_tag="BSU_22200" /old_locus_tag="BSU22200" /label="cotD gene" promotor_-10 complement(1931966..1931985) /Source="Nicolas_upshift_promotors" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="promotor_-10" upshifts complement(1931981) /Source="Nicolas_upshifts" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="upshifts" S_feature complement(1931983..1932137) /Source="Nicolas_S_feature" /locus_tag="new_2333056_2333210_c" /HighExp="LBGexp, dia15, Paraq, H2O2, Heat, G135, UNK1, Lbexp, BMM, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.808141" /TUshortSig="SigA, Sig-, SigA, SigA" /TUshortPSig="1, 0.419, 0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S839" promotor_-35 complement(1931999..1932007) /Source="Nicolas_upshift_promotors" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="promotor_-35" CDS complement(1932022..1932150) /locus_tag="BSU_22205" /old_locus_tag="BSU22205" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513975.1" /translation="MTLVIFKGRVGMYKGVFYLFFVVVFLIAFVFSNFKDSLIAHF*" /label="conserved protein of unknown function CDS" gene complement(1932022..1932150) /locus_tag="BSU_22205" /old_locus_tag="BSU22205" /label="gene" upshifts complement(1932137) /Source="Nicolas_upshifts" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="upshifts" S_feature complement(1932139..1932250) /Source="Nicolas_S_feature" /locus_tag="new_2333212_2333323_c" /HighExp="Sw, M40t90, Etha, Salt, M40t45, H2O2, S8, S6, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.419, 0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S840" promotor_-10 complement(1932140..1932159) /Source="Nicolas_upshift_promotors" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" promotor_-35 complement(1932175..1932179) /Source="Nicolas_upshift_promotors" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(1932251..1933492) /gene="yprB" /locus_tag="BSU_22210" /old_locus_tag="BSU22210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23249255; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding enzyme" /protein_id="NP_390103.1" /db_xref="EnsemblGenomes-Gn:BSU22210" /db_xref="EnsemblGenomes-Tr:CAB14138" /db_xref="GOA:P50837" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11452" /db_xref="UniProtKB/Swiss-Prot:P50837" /translation="MSLKGKLQRMKKHMALDEGEQKIEAGKQENHFDDIPFLEEWEAF GMKPFIFEDEYCLIREVEYPLSHRHGLYSFSELEEVITLWNQSGLSHTLSAKGYNKNN LFFFDTETTGLGGGAGNTIFLLGHARVYEDRVTVKQHLLPKPGNEVALYQSFLSEVDI TSLVTYNGKAFDWPQVKTRHTLIRDRLPKLPEFGHFDLLHGARRLWKHKMDRVSLGTV EKEELGIRRLEDTPGYLAPMLYFHFIKAQEPDLLKGVLHHNEMDVLSLISLYIHMSKK ILSESHAPKEHSEAYAMAKWFMAHKETDQAIKQLERLIEKSFEDQDSARLDLSLLYKK QNRLEEAVPLWEKLSRSQNQKCRYAAVIELAKYFEHKKKEFGKALQVAEQSLSDAACL SEKETEKLHVRIARLKRKYSS*" /label="yprB CDS" gene complement(1932251..1933492) /gene="yprB" /locus_tag="BSU_22210" /old_locus_tag="BSU22210" /label="yprB gene" promotor_-10 complement(1933206..1933224) /Source="Nicolas_upshift_promotors" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="promotor_-10" upshifts complement(1933215) /Source="Nicolas_upshifts" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="upshifts" promotor_-35 complement(1933239..1933246) /Source="Nicolas_upshift_promotors" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="promotor_-35" CDS complement(1933508..1935757) /gene="yprA" /locus_tag="BSU_22220" /old_locus_tag="BSU22220" /EC_number="3.6.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent RNA helicase" /protein_id="NP_390104.1" /db_xref="EnsemblGenomes-Gn:BSU22220" /db_xref="EnsemblGenomes-Tr:CAB14139" /db_xref="GOA:P50830" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR018973" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11451" /db_xref="UniProtKB/Swiss-Prot:P50830" /translation="MKKKSLTELISDLKGNENVVNWHEIEPREAKTRPMPESIDERIK AALSKRGIDELYTHQYSAFQYVQKGESIVTVTPTASGKTLCYNLPVLQSIAQDETNRA LYLFPTKALAQDQKSELNEIIDEMGIDIKSFTYDGDTSPAIRQKVRKAGHIVITNPDM LHSAILPHHTKWVSLFENLKYIVIDELHTYRGVFGSHVANVIRRLKRICRFYGSDPVF ICTSATIANPKELGEQLTGKPMRLVDDNGAPSGRKHFVFYNPPIVNKPLNIRRSATAE VNELAKEFLKNKVQTIVFARSRVRVEIILSHIQELVKKEIGTKSIRGYRGGYLPKERR EIERGLREGDILGVVSTNALELGVDIGQLQVCVMTGYPGSVASAWQQAGRAGRRHGES LIIMVANSTPIDQYIVRHPEYFFNRSPESARINPENLIILVDHLKCAAYELPFRADEE FGAMEVSDILEYLQEEAVLHRNGERYHWASESFPASNISLRSASQENVVIVDQSDIAN VRIIGEMDRFSAMTLLHDEAIYLHEGVQYQVEKLDWDHKKAYVRKVDVEYYTDANLAV QLKVLEIDKTKEKSRTSLHYGDVTVNALPTIFKKIKMTTFENIGSGPIHLPEEELHTS AAWLEIKTADEDIGEKTLEQLLLGISNVLQHIVPVYIMCDRNDVHVVSQIKAAHTGLP TIFLYDHYPGGIGLAEEVFKRFSDINEAAKQLITHCPCHDGCPSCIGTEIEGIKAKER ILQLLDQMS*" /label="yprA CDS" gene complement(1933508..1935757) /gene="yprA" /locus_tag="BSU_22220" /old_locus_tag="BSU22220" /label="yprA gene" promotor_-10 complement(1935773..1935792) /Source="Nicolas_upshift_promotors" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(1935789) /Source="Nicolas_upshifts" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="upshifts" promotor_-35 complement(1935806..1935812) /Source="Nicolas_upshift_promotors" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(1935860..1936366) /gene="ypqE" /locus_tag="BSU_22230" /old_locus_tag="BSU22230" /EC_number="2.7.1.-" /function="16.1: Circulate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10627040, 28731580; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase system enzyme IIA component" /protein_id="NP_390105.1" /db_xref="EnsemblGenomes-Gn:BSU22230" /db_xref="EnsemblGenomes-Tr:CAB14140" /db_xref="GOA:P50829" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR011055" /db_xref="SubtiList:BG11450" /db_xref="UniProtKB/Swiss-Prot:P50829" /translation="MLKKLFGMGKIQEKVTEEVIYSPADGTVMDLSDVPDPVFSQKMM GEGIAVEPSSGEIVSPAEGEVIQIFHTKHAVGIRTRSGIELLIHVGLETVNMNGEGFT AHIKEGDKVKVGDPLITCDLELIKEKASSTVIPIVIMNGEAVGSMVSAGEKAARKGES KLFTIKAK*" /label="ypqE CDS" gene complement(1935860..1936366) /gene="ypqE" /locus_tag="BSU_22230" /old_locus_tag="BSU22230" /label="ypqE gene" downshifts complement(1935883) /Source="Nicolas_upshifts" /id="D1166" /incds=0 /nref=88 /ntot=236 /MaxReadThrough="4.55156" /MaxDrop="6.1724" /score="32.5355561" /energy="-10.2" /TU="U1745" /idTUdmin="U1747" /TUdmin=808 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1936410..1936429) /Source="Nicolas_upshift_promotors" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(1936427) /Source="Nicolas_upshifts" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="upshifts" promotor_-35 complement(1936443..1936450) /Source="Nicolas_upshift_promotors" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" promotor_-35 1936448..1936457 /Source="Nicolas_upshift_promotors" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1936471..1936490 /Source="Nicolas_upshift_promotors" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1936483 /Source="Nicolas_upshifts" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="upshifts" CDS 1936504..1936923 /gene="ypqA" /locus_tag="BSU_22240" /old_locus_tag="BSU22240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative chaperone" /protein_id="NP_390106.1" /db_xref="EnsemblGenomes-Gn:BSU22240" /db_xref="EnsemblGenomes-Tr:CAB14141" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG11449" /db_xref="UniProtKB/Swiss-Prot:P50836" /translation="MEFHDDKKNELQKKEEIITEAIDTLFQSSAFGNLINGFQNLINS SLKDVQTTIHVRERDTGLYIDITIPATFRDGEIVVDVKSRYLHVTLQEKQKHQNEATF TSMTRTVQLPYEVRQEDMETSWNEQTMTLFFPKNKHE*" /label="ypqA CDS" gene 1936504..1936923 /gene="ypqA" /locus_tag="BSU_22240" /old_locus_tag="BSU22240" /label="ypqA gene" S_feature 1936924..1937074 /Source="Nicolas_S_feature" /locus_tag="new_2337997_2338147" /HighExp="S6, S8, S7, BT, S5, B36, B60, Pyr, G/S, nit" /AntisenseName="yppG" /AntisenseCor="0.95679380325708796" /AntisenseRegPval="-144.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S841" CDS complement(1936944..1937321) /gene="yppG" /locus_tag="BSU_22250" /old_locus_tag="BSU22250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein; methionine-glutamine-rich protein" /protein_id="NP_390107.1" /db_xref="EnsemblGenomes-Gn:BSU22250" /db_xref="EnsemblGenomes-Tr:CAB14142" /db_xref="InterPro:IPR025555" /db_xref="SubtiList:BG11448" /db_xref="UniProtKB/Swiss-Prot:P50835" /translation="MNGSSRSYPRQMGYYYPQHMQGYYQQAAPGYLEQQLPQQHYGQQ DYYQPYAPIQPMPMQPPVFSNPYPIPRPNQQQPSQFQSIMSQFKKANGQFDFNKMMDT TGQVMSAMNQVGSLIKGFTSFFK*" /label="yppG CDS" gene complement(1936944..1937321) /gene="yppG" /locus_tag="BSU_22250" /old_locus_tag="BSU22250" /label="yppG gene" downshifts complement(1936977) /Source="Nicolas_upshifts" /id="D1167" /incds=0 /nref=10 /ntot=43 /MaxReadThrough="3.01854" /MaxDrop="4.7006" /score="0.85617333" /energy="-12.8" /TU="U1747" /idTUdmin="U1747" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" S_feature 1937319..1937464 /Source="Nicolas_S_feature" /locus_tag="new_2338392_2338537" /HighExp="S6, S8, S7, BT, S5, B36, B60, Pyr, G/S, C30" /AntisenseName="yppG" /AntisenseCor="0.96504903995490698" /AntisenseRegPval="-156.6" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S842" promotor_-10 complement(1937351..1937369) /Source="Nicolas_upshift_promotors" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1937370) /Source="Nicolas_upshifts" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1937383..1937392) /Source="Nicolas_upshift_promotors" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1937465..1937484 /Source="Nicolas_upshift_promotors" /id="U1748" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig="0.994005994005994" /xcortree=2721 /SigmaFactorBS="catttgtcaaattgtgtcgaaagtttaaattttttaaaaaca gaaaaaagtcgaatcatTATGGTACCATATTTTCAATacagatgagaggggatgcacc a" /listShort="yppF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1937466 /Source="Nicolas_upshifts" /id="U1748" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig="0.994005994005994" /xcortree=2721 /SigmaFactorBS="catttgtcaaattgtgtcgaaagtttaaattttttaaaaaca gaaaaaagtcgaatcatTATGGTACCATATTTTCAATacagatgagaggggatgcacc a" /listShort="yppF" /GFF_Attribute="listLong" /label="upshifts" CDS 1937509..1937697 /gene="yppF" /locus_tag="BSU_22260" /old_locus_tag="BSU22260" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 22882546; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="NP_390108.1" /db_xref="EnsemblGenomes-Gn:BSU22260" /db_xref="EnsemblGenomes-Tr:CAB14143" /db_xref="InterPro:IPR025553" /db_xref="SubtiList:BG11447" /db_xref="UniProtKB/Swiss-Prot:P50834" /translation="MNVSYLSKRFAEMKKYETDCMNKLMDFAKFLYIQGHLSITEFRN SMKVLEANGAESPAYEMN*" /label="yppF CDS" gene 1937509..1937697 /gene="yppF" /locus_tag="BSU_22260" /old_locus_tag="BSU22260" /label="yppF gene" downshifts 1937713 /Source="Nicolas_upshifts" /id="D1168" /incds=0 /nref=112 /ntot=242 /MaxReadThrough="3.3677" /MaxDrop="5.69944" /score="0.283992322" /energy="-8.5" /TU="U1748" /idTUdmin="U1748" /TUdmin="-200" /isTUend="FALSE" /label="downshifts" CDS complement(1937736..1938107) /gene="yppE" /locus_tag="BSU_22270" /old_locus_tag="BSU22270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390109.1" /db_xref="EnsemblGenomes-Gn:BSU22270" /db_xref="EnsemblGenomes-Tr:CAB14144" /db_xref="InterPro:IPR014913" /db_xref="InterPro:IPR023351" /db_xref="PDB:2HFI" /db_xref="PDB:2IM8" /db_xref="SubtiList:BG11446" /db_xref="UniProtKB/Swiss-Prot:P50833" /translation="MLSQTLLEMTEQMIEVAEKGADRYQEGKNSNHSYDFFETIKPAV EENDELAARWAEGALELIKVRRPKYVHKEQIEAVKDNFLELVLQSYVHHIHKKRFKDI TESVLYTLHAVKDEIAREDSR*" /label="yppE CDS" gene complement(1937736..1938107) /gene="yppE" /locus_tag="BSU_22270" /old_locus_tag="BSU22270" /label="yppE gene" downshifts complement(1937769) /Source="Nicolas_upshifts" /id="D1169" /incds=0 /nref=158 /ntot=245 /MaxReadThrough="1.04225" /MaxDrop="5.78413" /score="-2.77698308" /energy="-10.3" /TU="NA" /idTUdmin="U1749" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1938119..1938138) /Source="Nicolas_upshift_promotors" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1938132) /Source="Nicolas_upshifts" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1938151..1938156) /Source="Nicolas_upshift_promotors" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1938153..1938398) /gene="yppD" /locus_tag="BSU_22280" /old_locus_tag="BSU22280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15687200; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="NP_390110.1" /db_xref="EnsemblGenomes-Gn:BSU22280" /db_xref="EnsemblGenomes-Tr:CAB14145" /db_xref="InterPro:IPR020252" /db_xref="SubtiList:BG11445" /db_xref="UniProtKB/Swiss-Prot:P50832" /translation="MSGYVCKTDILRMLSDIEDELTRAEQSLNHSVNALEAEMRETEN DRLSVLEEEIIDLHICINELYQSPEHRYAFEKVYRIG*" /label="yppD CDS" gene complement(1938153..1938398) /gene="yppD" /locus_tag="BSU_22280" /old_locus_tag="BSU22280" /label="yppD gene" promotor_-10 complement(1938424..1938442) /Source="Nicolas_upshift_promotors" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1938429) /Source="Nicolas_upshifts" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1938454..1938462) /Source="Nicolas_upshift_promotors" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1938548..1938554 /Source="Nicolas_upshift_promotors" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1938569..1938580 /Source="Nicolas_upshift_promotors" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1938576 /Source="Nicolas_upshifts" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="upshifts" CDS 1938597..1938701 /gene="sspM" /locus_tag="BSU_22290" /old_locus_tag="BSU22290" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054585.1" /db_xref="EnsemblGenomes-Gn:BSU22290" /db_xref="EnsemblGenomes-Tr:CAE01459" /db_xref="GOA:Q7WY65" /db_xref="SubtiList:BG14177" /db_xref="UniProtKB/Swiss-Prot:Q7WY65" /translation="MKTRPKKAGQQKKTESKAIDSLDKKLGGPNRPST*" /label="sspM CDS" gene 1938597..1938701 /gene="sspM" /locus_tag="BSU_22290" /old_locus_tag="BSU22290" /label="sspM gene" downshifts 1938683 /Source="Nicolas_upshifts" /id="D1170" /incds=0 /nref=31 /ntot=49 /MaxReadThrough="1.6498" /MaxDrop="6.01285" /score="0.283992322" /energy="-8.5" /TU="NA" /idTUdmin="U1751" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1938726..1939688) /gene="yppC" /locus_tag="BSU_22300" /old_locus_tag="BSU22300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390111.1" /db_xref="EnsemblGenomes-Gn:BSU22300" /db_xref="EnsemblGenomes-Tr:CAB14146" /db_xref="InterPro:IPR019658" /db_xref="SubtiList:BG10952" /db_xref="UniProtKB/Swiss-Prot:P39791" /translation="MNVQEQQAIRKLLSRIERQTKMKNADNISRTNAYKAFYDRHPEI KWSLLASFVSRNAGWSMTDLKGSLFQLGLRERQQKWFFLAYERANWLIFSDAYPQLLL YHWSKRVGKPLFHLLHVFGVSQFMSEEWTRFWHERNTERLMYALIINEQNTIQTPIIQ NPSFKKNVFDTIPFYLSDWFHFNTVIFPSSNGFFYGISVKRFSKAEERIRLGKQLSQL LFKPELFSSFYHFLHTVPHTGSRFDMEKMIGITKRTSPMLRTCYPELIHSLDGTKTDW FHGKIKKTFFRREELPKQIELTDWYLHKKRQLHALFAVEQWLKK*" /label="yppC CDS" gene complement(1938726..1939688) /gene="yppC" /locus_tag="BSU_22300" /old_locus_tag="BSU22300" /label="yppC gene" promotor_-35 1938856..1938865 /Source="Nicolas_upshift_promotors" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1938877..1938892 /Source="Nicolas_upshift_promotors" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1938877 /Source="Nicolas_upshifts" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1938881..1939216 /Source="Nicolas_S_feature" /locus_tag="new_2339954_2340289" /HighExp="T1.0H, T0.30H, T1.30H, H2O2, Paraq, LBGstat, T2.0H, T-0.40H, Salt, T2.30H" /AntisenseName="yppC" /AntisenseCor="-0.27690969451148201" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S843" promotor_-35 1939187..1939191 /Source="Nicolas_upshift_promotors" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1939207..1939226 /Source="Nicolas_upshift_promotors" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1939218..1939728 /Source="Nicolas_S_feature" /locus_tag="new_2340291_2340801" /HighExp="LBGstat, T1.0H, T1.30H, H2O2, T0.30H, Paraq, T2.0H, C30, G135, G180" /AntisenseName="yppC" /AntisenseCor="-0.312791370178301" /AntisenseRegPval="-6.8" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S844" upshifts 1939218 /Source="Nicolas_upshifts" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1939689..1940145) /Source="Nicolas_S_feature" /locus_tag="new_2340762_2341218_c" /HighExp="S8, S6, S7, S5, C30, G135, S4, BT, G180, Fru" /AntisenseName="recU" /AntisenseCor="-0.34780203121991599" /AntisenseRegPval="-8.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S845" CDS 1939729..1940349 /gene="recU" /locus_tag="BSU_22310" /old_locus_tag="BSU22310" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:14701911, 15317759, 16020779, 16024744, 19433509, 19542287, 20735784, 21600217, 27903910" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14701911, 15317759, 16020779, 16024744, 19433509, 19542287, 20735784, 21600217, 27903910; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction resolvase" /protein_id="NP_390112.1" /db_xref="EnsemblGenomes-Gn:BSU22310" /db_xref="EnsemblGenomes-Tr:CAB14147" /db_xref="GOA:P39792" /db_xref="InterPro:IPR004612" /db_xref="InterPro:IPR011335" /db_xref="PDB:1RZN" /db_xref="PDB:1ZP7" /db_xref="PDB:5FDK" /db_xref="SubtiList:BG10953" /db_xref="UniProtKB/Swiss-Prot:P39792" /translation="MIRYPNGKTFQPKHSVSSQNSQKRAPSYSNRGMTLEDDLNETNK YYLTNQIAVIHKKPTPVQIVNVHYPKRSAAVIKEAYFKQSSTTDYNGIYKGRYIDFEA KETKNKTSFPLQNFHDHQIEHMKQVKAQDGICFVIISAFDQVYFLEADKLFYFWDRKE KNGRKSIRKDELEETAYPISLGYAPRIDYISIIEQLYFSPSSGAKG*" /label="recU CDS" gene 1939729..1940349 /gene="recU" /locus_tag="BSU_22310" /old_locus_tag="BSU22310" /label="recU gene" promotor_-10 complement(1940134..1940145) /Source="Nicolas_upshift_promotors" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1940145) /Source="Nicolas_upshifts" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1940160..1940166) /Source="Nicolas_upshift_promotors" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1940371..1943115 /gene="ponA" /locus_tag="BSU_22320" /old_locus_tag="BSU22320" /EC_number="2.4.1.129" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10322023, 10692371, 12562814, 15262952, 18266856, 25355936, 27852437" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10322023, 10692371, 12562814, 15262952, 18266856, 25355936, 27852437; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan glycosyltransferase (penicillin-binding proteins 1A and 1B)" /protein_id="NP_390113.1" /db_xref="EnsemblGenomes-Gn:BSU22320" /db_xref="EnsemblGenomes-Tr:CAB14148" /db_xref="GOA:P39793" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR003961" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036116" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10954" /db_xref="UniProtKB/Swiss-Prot:P39793" /translation="MSDQFNSREARRKANSKSSPSPKKGKKRKKGGLFKKTLFTLLIL FVLGVVGGAVTFAVMVSDAPSLDESKLKTPYSSTIYDKNGKEIAEVGAEKRTYVSIDE IPDVVKEAFIATEDARFYEHHGIDPVRIGGALVANFKDGFGAEGGSTITQQVVKNSLL SHQKTLKRKVQEVWLSIQLERNYSKDEILEMYLNRIYFSPRAYGIGKAAEEFFGVTDL SKLTVEQAATLAGMPQSPTAYNPVKNPDKAEKRRNIVLSLMKKQGFISDSQYNKAKKV AVKDEGVVSQKEYEKASTNKYSAFVEEVMKEIDEKSDVDPSADGLKIYTTLDTKAQDK LDELMDGDTVGFTEGMQGGVTLLDTKNGEVRAIGAGRNQPVGGFNYATQTKAQPGSTI KPILDYGPVIENKKWSTYEQIDDSAYTYSNGKPIRDWDRKYLGPISMRYALAQSRNIP ALKAFQAVGKDTAVDFANGLGLGLTKDNVTEAYSIGGFGGNDGVSPLTMAGAYSAFGN NGTYNEPHFVKSIEFNDGTKLDLTPKSKSAMSDYTAFMITDMLKTAVKTGTGQLAQVP GVEVAGKTGTTNFDDNEVKRYNIASGGARDSWFVGYTPQYTAAVWTGMGENEAGKKSL SAEEQKVAKRIFAQLIADVDDGSGSFEKPDSVVEATVEKGSNPAKLAGPNTPSDKKLT EYFVKGTAPSTVSKTYEKEEKEETAKLSGLNVKYDKDNQSLTLSWNYDGDATFAVKQS VDGGSYSEIQNSSAKEAVISGVQPGSVYKFEVTAVSDDGKSTASTSYEVPKAEDDEDK KDQQQTDDEKQDDEKTQDDTQTDDSQKDDGQTDQDQTDDSTNDQDKKQDNTNTNPSDN NNQDQSNDNDNDNSNNQDTSDGDSNSGKNDSTGSDTNKNKTDTSNKTQTNSSSIEKTN *" /label="ponA CDS" gene 1940371..1943115 /gene="ponA" /locus_tag="BSU_22320" /old_locus_tag="BSU22320" /label="ponA gene" downshifts complement(1942785) /Source="Nicolas_upshifts" /id="D1171" /incds=1 /nref=1 /ntot=77 /MaxReadThrough="1.95969" /MaxDrop="2.87717" /score="24.9960782" /energy="-11.3" /TU="NA" /idTUdmin="U1755" /TUdmin=418 /isTUend="FALSE" /label="downshifts" downshifts 1943101 /Source="Nicolas_upshifts" /id="D1172" /incds=0 /nref=243 /ntot=302 /MaxReadThrough="1.61976" /MaxDrop="7.42523" /score="24.2831363" /energy="-14.6" /TU="U1753" /idTUdmin="U1752" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1943191..1943685) /gene="ypoC" /locus_tag="BSU_22330" /old_locus_tag="BSU22330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390114.1" /db_xref="EnsemblGenomes-Gn:BSU22330" /db_xref="EnsemblGenomes-Tr:CAB14149" /db_xref="SubtiList:BG10955" /db_xref="UniProtKB/Swiss-Prot:P39789" /translation="MTQAKEVLASYEQYLRSLGQKSSSDMKKTLQTNPVYFDFCTELQ GDLPWEDSGKYVPLLFEVWDDIKASLLPVFQTRKSRCDQNEMLKGIVCLLASLHWTAG EPVKSLDWQELREKSYPAKPINWAERVEFILLKPTQYHCFIQLDELITEMKKHFYKYH AMNR*" /label="ypoC CDS" gene complement(1943191..1943685) /gene="ypoC" /locus_tag="BSU_22330" /old_locus_tag="BSU22330" /label="ypoC gene" downshifts complement(1943204) /Source="Nicolas_upshifts" /id="D1173" /incds=0 /nref=116 /ntot=222 /MaxReadThrough="2.50883" /MaxDrop="5.43593" /score="29.5358766" /energy="-11.6" /TU="NA" /idTUdmin="U1755" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1943682..1944341) /gene="nth" /locus_tag="BSU_22340" /old_locus_tag="BSU22340" /EC_number="4.2.99.18" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9808040, 11160880, 12682299, 21954439, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9808040, 11160880, 12682299, 21954439, 24914186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease III, apurinic apyrimidic DNA lyase" /protein_id="NP_390115.1" /db_xref="EnsemblGenomes-Gn:BSU22340" /db_xref="EnsemblGenomes-Tr:CAB14150" /db_xref="GOA:P39788" /db_xref="InterPro:IPR000445" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR003651" /db_xref="InterPro:IPR004035" /db_xref="InterPro:IPR004036" /db_xref="InterPro:IPR005759" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR023170" /db_xref="SubtiList:BG10956" /db_xref="UniProtKB/Swiss-Prot:P39788" /translation="MLNLKQIEFCLDKIGDMFPHAECELVHSNPFELVVAVALSAQCT DALVNRVTKTLFQKYKRPEDYLAVPLEELQQDIKSIGLYRNKAKNIQKLSKMIIEDYG GEVPRDRDELVKLPGVGRKTANVVVSVAFGVPAIAVDTHVERVSKRLGICRWKDSVLE VEKTLMRKVPKEDWSVTHHRLIFFGRYHCKAQSPRCAECPLLSLCREGQKRDKKGLVK R*" /label="nth CDS" gene complement(1943682..1944341) /gene="nth" /locus_tag="BSU_22340" /old_locus_tag="BSU22340" /label="nth gene" CDS complement(1944360..1945058) /gene="dnaD" /locus_tag="BSU_22350" /old_locus_tag="BSU22350" /function="16.9: Replicate" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11222620, 12682299, 15556628, 15686560, 16002087, 16677303, 16855238, 17277452, 18206906, 21954439, 22821970, 23909787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11222620, 12682299, 15556628, 15686560, 16002087, 16677303, 16855238, 17277452, 18206906, 21954439, 22821970, 23909787; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA-remodelling primosomal protein" /protein_id="NP_390116.1" /db_xref="EnsemblGenomes-Gn:BSU22350" /db_xref="EnsemblGenomes-Tr:CAB14151" /db_xref="GOA:P39787" /db_xref="InterPro:IPR006343" /db_xref="InterPro:IPR034829" /db_xref="PDB:2V79" /db_xref="SubtiList:BG10957" /db_xref="UniProtKB/Swiss-Prot:P39787" /translation="MKKQQFIDMQEQGTSTIPNLLLTHYKQLGLNETELILLLKIKMH LEKGSYFPTPNQLQEGMSISVEECTNRLRMFIQKGFLFIEECEDQNGIKFEKYSLQPL WGKLYEYIQLAQNQTQERKAEGEQKSLYTIFEEEFARPLSPLECETLAIWQDQDQHDA QLIKHALKEAVLSGKLSFRYIDRILFEWKKNGLKTVEQAKIHSQKFRRVQAKQNEPQK EYKRQVPFYNWLEQ*" /label="dnaD CDS" gene complement(1944360..1945058) /gene="dnaD" /locus_tag="BSU_22350" /old_locus_tag="BSU22350" /label="dnaD gene" S_feature complement(1945059..1945150) /Source="Nicolas_S_feature" /locus_tag="new_2346132_2346223_c" /HighExp="LoTm, G180, Cold, G135, LBGstat, G150, C30, Etha, Oxctl, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.999, 0.994, 0.85, 1" /TUlongSig="SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.995" /label="S846" CDS complement(1945151..1946443) /gene="asnS" /locus_tag="BSU_22360" /old_locus_tag="BSU22360" /EC_number="6.1.1.22" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 26804570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparaginyl-tRNA synthetase" /protein_id="NP_390117.1" /db_xref="EnsemblGenomes-Gn:BSU22360" /db_xref="EnsemblGenomes-Tr:CAB14152" /db_xref="GOA:P39772" /db_xref="InterPro:IPR002312" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004522" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="SubtiList:BG10958" /db_xref="UniProtKB/Swiss-Prot:P39772" /translation="MKTTINQVYKHVGEEVTIGAWVANKRSSGKIAFLQLRDGTGFIQ GVVVKAEVEESIFQTAKSVTQETSLYIKGIVKEDERSPLGYELAVTDIEVIHEATDYP ITPKEHGTEFLMDHRHLWLRSKRQHAIMKIRNEIIRATYEFFNNEGFVKVDPPILTGS APEGTTELFATKYFDEDAYLSQSGQLYMEAAAMALGKVFSFGPTFRAEKSKTKRHLIE FWMIEPEMAFVEFEENLQVQENYVSFIVQSVLKNCKIELNTLGRDTSKLEQIKAPFPR ITYDEAIEFLKEKGFDDIEWGDDFGAPHETAIAEHYDKPVFITRYPTSLKPFYMQPAS DREDVVLCADLIAPEGYGEIIGGSERIHDMELLESRLKEHGLDSDAYKWYAELRKYGS VPHSGFGLGLERTVAWISGAPHVRETIPFPRLLNRLYP*" /label="asnS CDS" gene complement(1945151..1946443) /gene="asnS" /locus_tag="BSU_22360" /old_locus_tag="BSU22360" /label="asnS gene" S_feature complement(1946444..1946505) /Source="Nicolas_S_feature" /locus_tag="new_2347517_2347578_c" /HighExp="LBGexp, dia0, Lbexp, G150, G180, LPh, C30, Oxctl, LBGtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.999, 0.994, 0.85, 1" /TUlongSig="SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.995" /label="S847" promotor_-10 complement(1946505..1946524) /Source="Nicolas_upshift_promotors" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1946505) /Source="Nicolas_upshifts" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1946539..1946546) /Source="Nicolas_upshift_promotors" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1946587..1947768) /gene="aspB" /locus_tag="BSU_22370" /old_locus_tag="BSU22370" /EC_number="2.6.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:418816, 12670965, 22740702" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 418816, 12670965, 22740702; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="anabolic oxaloacetate / glutamate aminotransferase" /protein_id="NP_390118.1" /db_xref="EnsemblGenomes-Gn:BSU22370" /db_xref="EnsemblGenomes-Tr:CAB14153" /db_xref="GOA:P53001" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11513" /db_xref="UniProtKB/Swiss-Prot:P53001" /translation="MKLAKRVSALTPSTTLAITAKAKELKAAGHDVIGLGAGEPDFNT PQHIIDAAVRSMNEGHTKYTPSGGLAELKNSIAEKFKRDQNIEYKPSQIIVCTGAKHA LYTLFQVILDEEDEVIIPTPYWVSYPEQVKLAGGKPVYVEGLEENHFKISPEQLKNAI TEKTKAIVINSPSNPTGVMYTEEELSALGEVCLEHDILIVSDEIYEKLTYGGKKHVSI AQLSDRLKEQTVIINGVSKSHSMTGWRIGYAAGSEDIIKAMTNLASHSTSNPTSIAQY GAIAAYNGPSEPLEEMREAFEHRLNTIYAKLIEIPGFSCVKPEGAFYLFPNAKEAAQS CGFKDVDEFVKALLEEEKVAIVPGSGFGSPENVRLSYATSLDLLEEAIERIKRFVEKH S*" /label="aspB CDS" gene complement(1946587..1947768) /gene="aspB" /locus_tag="BSU_22370" /old_locus_tag="BSU22370" /label="aspB gene" downshifts complement(1946591) /Source="Nicolas_upshifts" /id="D1174" /incds=0 /nref=48 /ntot=196 /MaxReadThrough="6.37268" /MaxDrop="4.0831" /score="5.04709675" /energy="-9.3" /TU="U1756,U1758,U1760,U1761,U1762" /idTUdmin="U1760" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(1947791..1948276) /gene="tseB" /locus_tag="BSU_22380" /old_locus_tag="BSU22380" /experiment="publication(s) with functional evidences, PMID:25954268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25954268; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="suppressor of tetracyclin sensitivity of an ezrAmutant" /protein_id="NP_390119.1" /db_xref="EnsemblGenomes-Gn:BSU22380" /db_xref="EnsemblGenomes-Tr:CAB14154" /db_xref="GOA:P54396" /db_xref="InterPro:IPR025711" /db_xref="PDB:2GU3" /db_xref="SubtiList:BG11502" /db_xref="UniProtKB/Swiss-Prot:P54396" /translation="MRKKALIFTVIFGIIFLAVLLVSASIYKSAMAQKEEGHEAAAAE AKKETDLAHVDQVETFVGKEKYYVVKGTDKKGTALYVWVPADKKAKILSKEAKEGISE DKAAKIIKDEGLVSKQKEVHLAREGNVLLWEVTYLDKEGQYSLSYVDFTTGKILKNIT P*" /label="tseB CDS" gene complement(1947791..1948276) /gene="tseB" /locus_tag="BSU_22380" /old_locus_tag="BSU22380" /label="tseB gene" promotor_-10 complement(1948224..1948243) /Source="Nicolas_upshift_promotors" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1948241) /Source="Nicolas_upshifts" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1948256..1948263) /Source="Nicolas_upshift_promotors" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1948285..1948455) /gene="ypmA" /locus_tag="BSU_22390" /old_locus_tag="BSU22390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390120.1" /db_xref="EnsemblGenomes-Gn:BSU22390" /db_xref="EnsemblGenomes-Tr:CAB14155" /db_xref="InterPro:IPR012190" /db_xref="SubtiList:BG11501" /db_xref="UniProtKB/Swiss-Prot:P54395" /translation="MESKIEILSTINVEHSDDLYKIVDTLNRTLKRDNLMFGLALDEE NKNQAVFTIYRT*" /label="ypmA CDS" gene complement(1948285..1948455) /gene="ypmA" /locus_tag="BSU_22390" /old_locus_tag="BSU22390" /label="ypmA gene" S_feature complement(1948456..1948527) /Source="Nicolas_S_feature" /locus_tag="new_2349529_2349600_c" /HighExp="H2O2, T0.30H, T0.0H, dia15, T-0.40H, T-1.10H, G135, T1.0H, G180, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.136042" /TUshortSig="SigA, SigWXY, SigA, SigA, SigA" /TUshortPSig="0.85, 1, 1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S848" promotor_-35 1948489..1948495 /Source="Nicolas_upshift_promotors" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1948510..1948529) /Source="Nicolas_upshift_promotors" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1948510..1948521 /Source="Nicolas_upshift_promotors" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1948517..1948591 /Source="Nicolas_S_feature" /locus_tag="new_2349590_2349664" /HighExp="S8, S6, S5, S7, nit, BT, G/S, Pyr, C30, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S849" upshifts 1948517 /Source="Nicolas_upshifts" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1948527) /Source="Nicolas_upshifts" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1948529..1948597) /Source="Nicolas_S_feature" /locus_tag="new_2349602_2349670_c" /HighExp="T0.30H, T1.0H, T-0.40H, T1.30H, T0.0H, Salt, H2O2, T-1.10H, Oxctl, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA, SigA, SigA" /TUshortPSig="1, 1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S850" promotor_-35 complement(1948545..1948551) /Source="Nicolas_upshift_promotors" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1948561 /Source="Nicolas_upshifts" /id="D1175" /incds=0 /nref=8 /ntot=26 /MaxReadThrough="0.48859" /MaxDrop="6.02806" /score="18.4569945" /energy="-8.4" /TU="NA" /idTUdmin="U1757" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1948598..1951393) /gene="dinG" /locus_tag="BSU_22400" /old_locus_tag="BSU22400" /EC_number="3.6.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8385320, 12060778, 17416902, 21546913, 22166102, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8385320, 12060778, 17416902, 21546913, 22166102, 28527403; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="damage inducible ATP-dependent 3'->5' nuclease" /protein_id="NP_390121.1" /db_xref="EnsemblGenomes-Gn:BSU22400" /db_xref="EnsemblGenomes-Tr:CAB14156" /db_xref="GOA:P54394" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR006054" /db_xref="InterPro:IPR006310" /db_xref="InterPro:IPR006555" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014013" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11515" /db_xref="UniProtKB/Swiss-Prot:P54394" /translation="MNKQRFVVIDVETTGNSPKKGDKIIQIAAVVIENGQITERFSKY INPNKSIPAFIEQLTGISNQMVENEQPFEAVAEEVFQLLDGAYFVAHNIHFDLGFVKY ELHKAGFQLPDCEVLDTVELSRIVFPGFEGYKLTELSEELQLRHDQPHRADSDAEVTG LIFLEILEKLRQLPYPTLKQLRRLSQHFISDLTHLLDMFINENRHTEIPGYTRFSSFS VREPEAIDVRINEDENFSFEIESWEAGNEKALSELMPGYEKRDGQMMMMREVADAFAN REHALIEAPPGIGKTIGYLIPAALFAKKSKKPVIISTYSTLLQQQILTKDLPIVQDLF PFPVTAAILKGQSHYLCLYKFEQVLHEEDDNYDAVLTKAQLLVWLTETNTGDVAELNL PSGGKLLWDRLAYDDDSYKRSRSEHVIGFYERAKQIAMRSDLVITNHSLLLTDEGSHK KRLPESGTFIIDEAHHFERAASEHLGKRATYIELHTKLSRIGTLKEQGLLKKMRQLFQ RNSLPVDSFFELEEWLQHVQAESDAFFSSVHSFVKRRKPKEDLNRLVFKVNKESQDKS WSILTDGAERLCSMLTHLQQLFEAQSSLMEKHLKGMKSKTVFLADEYQRSMKGLQHYC QTLQKLFFGSDDDEAVWIEIDAKGAKNAVAIYAQPLEPGELLADQFFARKNSVVLTSA TLTVEGSFQFMIERLGLSDFFPRTMRIESPFSYDERMQVMIPKEMKSIQDTGQPEFIQ DTARYIELMAKEKQPKILVLFTSHDMLKKVHQELKHNMSASGIQLLAQGITGGSPGKL MKTFKTSNQAILLGTNHFWEGVDFPGDELTTVMIVRLPFRSPDHPLHAAKCELARKKG KNPFQTVSLPEAVLTFRQGIGRLLRSAGDKGTIIILDRRIKTAGYGRLFLDALPTTSV SEMTDSELEAYVAGEKE*" /label="dinG CDS" gene complement(1948598..1951393) /gene="dinG" /locus_tag="BSU_22400" /old_locus_tag="BSU22400" /label="dinG gene" promotor_-35 1949066..1949070 /Source="Nicolas_upshift_promotors" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1949067 /Source="Nicolas_upshifts" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1949072..1949076 /Source="Nicolas_upshift_promotors" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1949723..1949738) /Source="Nicolas_upshift_promotors" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-10" upshifts complement(1949737) /Source="Nicolas_upshifts" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="upshifts" promotor_-35 complement(1949751..1949760) /Source="Nicolas_upshift_promotors" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-35" S_feature complement(1951394..1951518) /Source="Nicolas_S_feature" /locus_tag="new_2352467_2352591_c" /HighExp="dia15, Diami, H2O2, Heat, LBGstat, C30, G180, G135, Oxctl, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S851" CDS complement(1951519..1951902) /gene="panD" /locus_tag="BSU_22410" /old_locus_tag="BSU22410" /EC_number="4.1.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9169598, 12600205, 15033515, 26762040" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9169598, 12600205, 15033515, 26762040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate 1-decarboxylase" /protein_id="NP_390122.1" /db_xref="EnsemblGenomes-Gn:BSU22410" /db_xref="EnsemblGenomes-Tr:CAB14157" /db_xref="GOA:P52999" /db_xref="InterPro:IPR003190" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG11493" /db_xref="UniProtKB/Swiss-Prot:P52999" /translation="MYRTMMSGKLHRATVTEANLNYVGSITIDEDLIDAVGMLPNEKV QIVNNNNGARLETYIIPGKRGSGVICLNGAAARLVQEGDKVIIISYKMMSDQEAASHE PKVAVLNDQNKIEQMLGNEPARTIL*" /label="panD CDS" gene complement(1951519..1951902) /gene="panD" /locus_tag="BSU_22410" /old_locus_tag="BSU22410" /label="panD gene" CDS complement(1951904..1952764) /gene="panC" /locus_tag="BSU_22420" /old_locus_tag="BSU22420" /EC_number="6.3.2.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17175524, 7037743; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate synthetase" /protein_id="NP_390123.1" /db_xref="EnsemblGenomes-Gn:BSU22420" /db_xref="EnsemblGenomes-Tr:CAB14158" /db_xref="GOA:P52998" /db_xref="InterPro:IPR003721" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11520" /db_xref="UniProtKB/Swiss-Prot:P52998" /translation="MRQITDISQLKEAIKQYHSEGKSIGFVPTMGFLHEGHLTLADKA RQENDAVIMSIFVNPAQFGPNEDFEAYPRDIERDAALAENAGVDILFTPDAHDMYPGE KNVTIHVERRTDVLCGRSREGHFDGVAIVLTKLFNLVKPTRAYFGLKDAQQVAVVDGL ISDFFMDIELVPVDTVREEDGLAKSSRNVYLTAEERKEAPKLYRALQTSAELVQAGER DPEAVIKAAKDIIETTSGTIDYVELYSYPELEPVNEIAGKMILAVAVAFSKARLIDNI IIDIREMERI*" /label="panC CDS" gene complement(1951904..1952764) /gene="panC" /locus_tag="BSU_22420" /old_locus_tag="BSU22420" /label="panC gene" CDS complement(1952766..1953599) /gene="panB" /locus_tag="BSU_22430" /old_locus_tag="BSU22430" /EC_number="2.1.2.11" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1844812, 8096212; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ketopantoate hydroxymethyltransferase" /protein_id="NP_390124.1" /db_xref="EnsemblGenomes-Gn:BSU22430" /db_xref="EnsemblGenomes-Tr:CAB14159" /db_xref="GOA:P52996" /db_xref="InterPro:IPR003700" /db_xref="InterPro:IPR015813" /db_xref="SubtiList:BG11519" /db_xref="UniProtKB/Swiss-Prot:P52996" /translation="MKTKLDFLKMKESEEPIVMLTAYDYPAAKLAEQAGVDMILVGDS LGMVVLGLDSTVGVTVADMIHHTKAVKRGAPNTFIVTDMPFMSYHLSKEDTLKNAAAI VQESGADALKLEGGEGVFESIRALTLGGIPVVSHLGLTPQSVGVLGGYKVQGKDEQSA KKLIEDSIKCEEAGAMMLVLECVPAELTAKIAETLSIPVIGIGAGVKADGQVLVYHDI IGHGVERTPKFVKQYTRIDETIETAISGYVQDVRHRAFPEQKHSFQMNQTVLDGLYGG K*" /label="panB CDS" gene complement(1952766..1953599) /gene="panB" /locus_tag="BSU_22430" /old_locus_tag="BSU22430" /label="panB gene" S_feature complement(1953600..1953807) /Source="Nicolas_S_feature" /locus_tag="new_2354673_2354880_c" /HighExp="LBGstat, dia15, Diami, H2O2, MG 15, Heat, Oxctl, MG 25, MG 10, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S852" promotor_-10 complement(1953802..1953821) /Source="Nicolas_upshift_promotors" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1953807) /Source="Nicolas_upshifts" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1953838..1953842) /Source="Nicolas_upshift_promotors" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1953845..1954822) /gene="birA" /locus_tag="BSU_22440" /old_locus_tag="BSU22440" /EC_number="6.3.4.15" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12368242, 15459338, 28466579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12368242, 15459338, 28466579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin acetyl-CoA-carboxylase ligase and biotin regulon repressor (BirA-biotinoyl-5'-AMP)" /protein_id="NP_390125.1" /db_xref="EnsemblGenomes-Gn:BSU22440" /db_xref="EnsemblGenomes-Tr:CAB14160" /db_xref="GOA:P0CI75" /db_xref="InterPro:IPR003142" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR004408" /db_xref="InterPro:IPR004409" /db_xref="InterPro:IPR008988" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR030855" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11206" /db_xref="UniProtKB/Swiss-Prot:P0CI75" /translation="MRSTLRKDLIELFSQAGNEFISGQKISDALGCSRTAVWKHIEEL RKEGYEVEAVRRKGYRLIKKPGKLSESEIRFGLKTEVMGQHLIYHDVLSSTQKTAHEL ANNNAPEGTLVVADKQTAGRGRMSRVWHSQEGNGVWMSLILRPDIPLQKTPQLTLLAA VAVVQGIEEAAGIQTDIKWPNDILINGKKTVGILTEMQAEEDRVRSVIIGIGINVNQQ PNDFPDELKDIATSLSQAAGEKIDRAGVIQHILLCFEKRYRDYMTHGFTPIKLLWESY ALGIGTNMRARTLNGTFYGKALGIDDEGVLLLETNEGIKKIYSADIELG*" /label="birA CDS" gene complement(1953845..1954822) /gene="birA" /locus_tag="BSU_22440" /old_locus_tag="BSU22440" /label="birA gene" CDS complement(1954807..1956000) /gene="cca" /locus_tag="BSU_22450" /old_locus_tag="BSU22450" /EC_number="2.7.7.72" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9829937, 16109934, 20360175, 22940585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829937, 16109934, 20360175, 22940585; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA nucleotidyltransferase" /protein_id="NP_390126.1" /db_xref="EnsemblGenomes-Gn:BSU22450" /db_xref="EnsemblGenomes-Tr:CAB14161" /db_xref="GOA:P42977" /db_xref="InterPro:IPR002646" /db_xref="InterPro:IPR023068" /db_xref="InterPro:IPR032810" /db_xref="InterPro:IPR032828" /db_xref="SubtiList:BG11208" /db_xref="UniProtKB/Swiss-Prot:P42977" /translation="MEKVFIKALPVLRILIEAGHQAYFVGGAVRDSYMKRTIGDVDIA TDAAPDQVERLFQRTVDVGKEHGTIIVLWEDETYEVTTFRTESDYVDFRRPSEVQFIS SLEEDLKRRDLTINAMAMTADGKVLDYFGGKKDIDQKVIRTVGKPEDRFQEDALRMLR AVRFMSQLGFTLSPETEEAIAKEKSLLSHVSVERKTIEFEKLLQGRASRQALQTLIQT RLYEELPGFYHKRENLISTSEFPFFSLTSREELWAALLINLGIVLKDAPLFLKAWKLP GKVIKEAIHIADTFGQSLDAMTMYRAGKKALLSAAKISQLRQNEKLDEKKLKDIQYAY QNLPIKSLKDLDITGKDLLALRNRPAGKWVSEELQWIEQAVVTGKLSNQKKHIEEWLK TCGQH*" /label="cca CDS" gene complement(1954807..1956000) /gene="cca" /locus_tag="BSU_22450" /old_locus_tag="BSU22450" /label="cca gene" CDS complement(1956005..1957138) /gene="bshA" /locus_tag="BSU_22460" /old_locus_tag="BSU22460" /EC_number="2.4.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16751541, 20308541, 22569254, 27454321, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751541, 20308541, 22569254, 27454321, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-alpha-D-glucosaminyl L-malate synthase;malate glycosyltransferase for bacillithiol synthesis" /protein_id="NP_390127.1" /db_xref="EnsemblGenomes-Gn:BSU22460" /db_xref="EnsemblGenomes-Tr:CAB14162" /db_xref="GOA:P42982" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR023881" /db_xref="InterPro:IPR028098" /db_xref="PDB:5D00" /db_xref="PDB:5D01" /db_xref="SubtiList:BG11213" /db_xref="UniProtKB/Swiss-Prot:P42982" /translation="MRKLKIGITCYPSVGGSGIIATELGKQLAEKGHEIHFITSSIPF RLNTYHPNIHFHEVEVNQYAVFKYPPYDLTLASKIAEVAERENLDIIHAHYALPHAVC AYLAKQMLKRNIGIVTTLHGTDITVLGYDPSLKDLIRFAIESSDRVTAVSSALAAETY DLIKPEKKIETIYNFIDERVYLKKNTAAIKEKHGILPDEKVVIHVSNFRKVKRVQDVI RVFRNIAGKTKAKLLLVGDGPEKSTACELIRKYGLEDQVLMLGNQDRVEDLYSISDLK LLLSEKESFGLVLLEAMACGVPCIGTNIGGIPEVIKNNVSGFLVDVGDVTAATARAMS ILEDEQLSNRFTKAAIEMLENEFSSKKIVSQYEQIYADLAEPE*" /label="bshA CDS" gene complement(1956005..1957138) /gene="bshA" /locus_tag="BSU_22460" /old_locus_tag="BSU22460" /label="bshA gene" CDS complement(1957135..1957845) /gene="bshBA" /locus_tag="BSU_22470" /old_locus_tag="BSU22470" /EC_number="3.5.1.-" /function="4.10: Glutathione and analogs" /experiment="publication(s) with functional evidences, PMID:11004195, 20308541, 23894131, 28117687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004195, 20308541, 23894131, 28117687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-alpha-D-glucosaminyl L-malate deacetylase 1; malate N-acetylglucosamine N-acetyl hydrolase" /protein_id="NP_390128.2" /db_xref="EnsemblGenomes-Gn:BSU22470" /db_xref="EnsemblGenomes-Tr:CAB14163" /db_xref="GOA:P42981" /db_xref="InterPro:IPR003737" /db_xref="InterPro:IPR023842" /db_xref="InterPro:IPR024078" /db_xref="SubtiList:BG11212" /db_xref="UniProtKB/Swiss-Prot:P42981" /translation="MYNADVLAFGAHSDDVEIGMGGTIAKFVKQEKKVMICDLTEAEL SSNGTVSLRKEEAAEAARILGADKRIQLTLPDRGLIMSDQAIRSIVTVIRICRPKAVF MPYKKDRHPDHGNAAALVEEAIFSAGIHKYKDEKSLPAHKVSKVYYYMINGFHQPDFV IDISDTIEAKKQSLNAYKSQFIPSKDSVSTPLTNGYIEIVEAREKLYGKEAGVEYAEG FFSKRMLMLDHDVLGGEQ*" /label="bshBA CDS" gene complement(1957135..1957845) /gene="bshBA" /locus_tag="BSU_22470" /old_locus_tag="BSU22470" /label="bshBA gene" CDS complement(1957838..1958251) /gene="mgsA" /locus_tag="BSU_22480" /old_locus_tag="BSU22480" /EC_number="4.2.3.3" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9489667, 10368300, 10715115, 11423008, 15489434, 21992469, 23894131, 28807600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9489667, 10368300, 10715115, 11423008, 15489434, 21992469, 23894131, 28807600; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglyoxal synthase" /protein_id="NP_390129.1" /db_xref="EnsemblGenomes-Gn:BSU22480" /db_xref="EnsemblGenomes-Tr:CAB14164" /db_xref="GOA:P42980" /db_xref="InterPro:IPR004363" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR018148" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG11211" /db_xref="UniProtKB/Swiss-Prot:P42980" /translation="MKIALIAHDKKKQDMVQFTTAYRDILKNHDLYATGTTGLKIHEA TGLQIERFQSGPLGGDQQIGALIAANALDLVIFLRDPLTAQPHEPDVSALIRLCDVYS IPLATNMGTAEILVRTLDEGVFEFRDLLRGEEPNV*" /label="mgsA CDS" gene complement(1957838..1958251) /gene="mgsA" /locus_tag="BSU_22480" /old_locus_tag="BSU22480" /label="mgsA gene" CDS complement(1958267..1959070) /gene="dapB" /locus_tag="BSU_22490" /old_locus_tag="BSU22490" /EC_number="1.17.1.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6422596, 9398235, 12682299, 20503968; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(4S)-4-hydroxy-2,3,4, 5-tetrahydro-(2S)-dipicolinic acid (HTPA) dehydratase reductase" /protein_id="NP_390130.1" /db_xref="EnsemblGenomes-Gn:BSU22490" /db_xref="EnsemblGenomes-Tr:CAB14165" /db_xref="GOA:P42976" /db_xref="InterPro:IPR000846" /db_xref="InterPro:IPR022663" /db_xref="InterPro:IPR022664" /db_xref="InterPro:IPR023940" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11207" /db_xref="UniProtKB/Swiss-Prot:P42976" /translation="MSNETIKLVIAGPRGRMGQEAVKLAERTPHFDLVGAIDHTYDQQ KLSDVMPVESDAFIYTDIHACFTETQPDVLIDLTTPEIGKVHTKIALEHGVRPVVGTT GFSEADLKELTSLTEEKGIGAIIAPNFALGAILMMKFSKMAANYFEDVEIIELHHDQK LDAPSGTALKTAEMISEVRKEKQQGHPDEKEILPGARGAEQNGIRLHSVRLPGLIAHQ EVMFGMDGQTLQIRHDSYNRASFMSGVKLSVEQVMKIDQLVYGLENIID*" /label="dapB CDS" gene complement(1958267..1959070) /gene="dapB" /locus_tag="BSU_22490" /old_locus_tag="BSU22490" /label="dapB gene" CDS complement(1959082..1959417) /gene="ypjD" /locus_tag="BSU_22500" /old_locus_tag="BSU22500" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16390452, 20529853, 20944217, 21733847, 24339782, 26920050, 28117687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxidized nucleotide pyrophosphohydrolase" /protein_id="NP_390131.1" /db_xref="EnsemblGenomes-Gn:BSU22500" /db_xref="EnsemblGenomes-Tr:CAB14166" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR012359" /db_xref="PDB:2GTA" /db_xref="SubtiList:BG11210" /db_xref="UniProtKB/Swiss-Prot:P42979" /translation="MSDKTMKDIQAEVDRYIGQFKEGYFSPLAMMARLTEELGELARE VNHRYGEKPKKATEDDKSMEEEIGDVLFVLVCLANSLDISLEEAHDRVMHKFNTRDKD RWTRKEEGK*" /label="ypjD CDS" gene complement(1959082..1959417) /gene="ypjD" /locus_tag="BSU_22500" /old_locus_tag="BSU22500" /label="ypjD gene" promotor_-10 complement(1959437..1959456) /Source="Nicolas_upshift_promotors" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-10" upshifts complement(1959447) /Source="Nicolas_upshifts" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="upshifts" promotor_-35 complement(1959470..1959477) /Source="Nicolas_upshift_promotors" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-35" promotor_-35 1959486..1959493 /Source="Nicolas_upshift_promotors" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1959502..1959521) /Source="Nicolas_upshift_promotors" /id="U1764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.415584415584416" /psig="0.995004995004995" /xcortree=2307 /SigmaFactorBS="tttttaatctaatttctccaagcatcacacaaaacccctttt ccttccattagatagcgtTTATATTATAGTGGATGAAAaagaaaacagcaaacgtgct t" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA" /listLong="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1959507..1959526 /Source="Nicolas_upshift_promotors" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1959513 /Source="Nicolas_upshifts" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1959521) /Source="Nicolas_upshifts" /id="U1764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.415584415584416" /psig="0.995004995004995" /xcortree=2307 /SigmaFactorBS="tttttaatctaatttctccaagcatcacacaaaacccctttt ccttccattagatagcgtTTATATTATAGTGGATGAAAaagaaaacagcaaacgtgct t" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA" /listLong="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /label="upshifts" CDS 1959557..1960429 /gene="ypjC" /locus_tag="BSU_22510" /old_locus_tag="BSU22510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390132.2" /db_xref="EnsemblGenomes-Gn:BSU22510" /db_xref="EnsemblGenomes-Tr:CAB14167" /db_xref="GOA:P42978" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG11209" /db_xref="UniProtKB/Swiss-Prot:P42978" /translation="MLGEIRLKNIFFILIGAAIFSFGLVHFNMQNNLAEGGFTGITLL LYALFHISPSISNLVLNIPIFFIGWRLLGRTMFVYTLVGTVALSLFLSIFQRYEIHMP LQHDLALAALFAGVFIGAGLGIIFKFGGTTGGVDIIARLVNKYFGIPMGRTMFAFDAC VIILSLLTYLSYKEAMYTLVAVFVAARLIDFIQEGGYAAKGATIISSKNDLIQKKILE EMERGVTILKGQGSYTKEDIDVLYCVVPKNELVMLKSVINSIDPHAFVAVSDVHDVLG EGFTLDENKNPLPR*" /label="ypjC CDS" gene 1959557..1960429 /gene="ypjC" /locus_tag="BSU_22510" /old_locus_tag="BSU22510" /label="ypjC gene" CDS complement(1960471..1961265) /gene="ypjB" /locus_tag="BSU_22520" /old_locus_tag="BSU22520" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12662922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="sporulation septum-associated protein" /protein_id="NP_390133.1" /db_xref="EnsemblGenomes-Gn:BSU22520" /db_xref="EnsemblGenomes-Tr:CAB14168" /db_xref="GOA:P54393" /db_xref="InterPro:IPR014231" /db_xref="SubtiList:BG11500" /db_xref="UniProtKB/Swiss-Prot:P54393" /translation="MKRKLTICLLIALIFYNGNAKAAERGSLEELNDLSDTVFQMTRQ AKYEEALQVLEYFEKTLKSAEKKQQDPMLTGAQIRQITLGYNDMVRSLKQADTSDTQK LRAAAQFRMLMDAVDNRSDPLWGSLEKPIMEAFTELKRDVQKNGSTSFHEKWNEFISL YDLIYPSLTIDVSEDQLETVGKHIDVIEQEEFQQMTESTKLERLSLLQHDLKNVFDRV EEDDADPSLLWVIITTGSIIITALTYVGYRKYKAEKNKLKKRDYPK*" /label="ypjB CDS" gene complement(1960471..1961265) /gene="ypjB" /locus_tag="BSU_22520" /old_locus_tag="BSU22520" /label="ypjB gene" downshifts complement(1960496) /Source="Nicolas_upshifts" /id="D1176" /incds=0 /nref=4 /ntot=106 /MaxReadThrough="1.96946" /MaxDrop="3.51024" /score="34.9661402" /energy="-11.3" /TU="NA" /idTUdmin="U1765" /TUdmin=198 /isTUend="FALSE" /label="downshifts" S_feature complement(1961266..1961333) /Source="Nicolas_S_feature" /locus_tag="new_2362339_2362406_c" /HighExp="LBGstat, C30, S0, LoTm, G180, G135, G150, Oxctl, Paraq, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.866" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.999" /label="S853" CDS complement(1961334..1961891) /gene="ypjA" /locus_tag="BSU_22530" /old_locus_tag="BSU22530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral inner membrane protein of unknown function" /protein_id="NP_390134.1" /db_xref="EnsemblGenomes-Gn:BSU22530" /db_xref="EnsemblGenomes-Tr:CAB14169" /db_xref="GOA:P54392" /db_xref="InterPro:IPR009845" /db_xref="SubtiList:BG11499" /db_xref="UniProtKB/Swiss-Prot:P54392" /translation="MLILVLAINFLGTVYGYYWYLPQLLETPARFLIFVPDSPTATFF FLFVLLAFLMKRNAPLLEALALVTLVKYGLWAVAMNFLVLAVTGDLPWEGYMLIASHF AMAVQGVLYSPYFRFSFWHLAIAAVWTLHNDVIDYLFDMMPQYSMLSDYMTEIGYGTF WLSIFSIALAYFLVVSKKQTKLELM*" /label="ypjA CDS" gene complement(1961334..1961891) /gene="ypjA" /locus_tag="BSU_22530" /old_locus_tag="BSU22530" /label="ypjA gene" S_feature complement(1961892..1961971) /Source="Nicolas_S_feature" /locus_tag="new_2362965_2363044_c" /HighExp="C30, UNK1, G135, BMM, G150, G180, Oxctl, LoTm, Paraq, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.866" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.999" /label="S854" downshifts complement(1962016) /Source="Nicolas_upshifts" /id="D1177" /incds=0 /nref=131 /ntot=215 /MaxReadThrough="3.97061" /MaxDrop="6.41485" /score="13.3880841" /energy="-8" /TU="U1765" /idTUdmin="U1767" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1962038..1962805) /gene="qcrC" /locus_tag="BSU_22540" /old_locus_tag="BSU22540" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 19114526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (cytochrome cc subunit)" /protein_id="NP_390135.1" /db_xref="EnsemblGenomes-Gn:BSU22540" /db_xref="EnsemblGenomes-Tr:CAB14170" /db_xref="GOA:P46913" /db_xref="InterPro:IPR005798" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012049" /db_xref="InterPro:IPR027387" /db_xref="InterPro:IPR036150" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG11327" /db_xref="UniProtKB/Swiss-Prot:P46913" /translation="MHRGKGMKFVGDSRIPAEKKPNIPKDYSEYPGKTEAFWPNFLLK EWMVGAVFLIGFLVLTIVHQPPLERMADPTDTGYIPLPDWYFLFLYQLLKYEYAAGSF TVVGAMIMPGLAFGALLLAPFLDRGTERRPWKRPVAVGMMLLAISAAVFLTWQSVATH DWAKAEEQGKITKEADIDTNAEGYKVFKEQGCISCHGDNLQGGAAGPSLVDSGLKPDE IKKIAVEGKGKMPAGVFKGNDKQLEELAKFISETTAK*" /label="qcrC CDS" gene complement(1962038..1962805) /gene="qcrC" /locus_tag="BSU_22540" /old_locus_tag="BSU22540" /label="qcrC gene" CDS complement(1962840..1963514) /gene="qcrB" /locus_tag="BSU_22550" /old_locus_tag="BSU22550" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 15849754, 16850406; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (cytochrome b subunit)" /protein_id="NP_390136.1" /db_xref="EnsemblGenomes-Gn:BSU22550" /db_xref="EnsemblGenomes-Tr:CAB14171" /db_xref="GOA:P46912" /db_xref="InterPro:IPR005797" /db_xref="InterPro:IPR016174" /db_xref="InterPro:IPR023530" /db_xref="InterPro:IPR027387" /db_xref="SubtiList:BG11326" /db_xref="UniProtKB/Swiss-Prot:P46912" /translation="MLNKIYDWVDERLDITPMWRDIADHEVPEHVNPAHHFSAFVYCF GGLTFFVTVIQVLSGMFLTMYYVPDIKNAWESVYYLQNEVAFGQIVRGMHHWGASLVI VMMFLHTLRVFFQGAYKKPRELNWIVGVLIFFVMLGLGFTGYLLPWDMKALFATKVGL QIAEATPLIGTQVKTLLAGHPDIVGAQTLTRFFAIHVFFLPAALFGLMAAHFIMIRKQ GISGPL*" /label="qcrB CDS" gene complement(1962840..1963514) /gene="qcrB" /locus_tag="BSU_22550" /old_locus_tag="BSU22550" /label="qcrB gene" CDS complement(1963516..1964019) /gene="qcrA" /locus_tag="BSU_22560" /old_locus_tag="BSU22560" /EC_number="1.10.2.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 24652282, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (iron-sulfur subunit)" /protein_id="NP_390137.1" /db_xref="EnsemblGenomes-Gn:BSU22560" /db_xref="EnsemblGenomes-Tr:CAB14172" /db_xref="GOA:P46911" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR014349" /db_xref="InterPro:IPR014909" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG11325" /db_xref="UniProtKB/Swiss-Prot:P46911" /translation="MGGKHDISRRQFLNYTLTGVGGFMAASMLMPMVRFALDPVLKST GKQDMVQVVSVDELTKEPQRFDFKINQVDAWYESEESRSAWVFKNGDEIVALSPICKH LGCTVNWNSDPKNPNKFFCPCHYGLYEKDGTNVPGTPPLAPLDHYEQEVKDGFLYLGK AKPKGEG*" /label="qcrA CDS" gene complement(1963516..1964019) /gene="qcrA" /locus_tag="BSU_22560" /old_locus_tag="BSU22560" /label="qcrA gene" downshifts 1964028 /Source="Nicolas_upshifts" /id="D1178" /incds=0 /nref=1 /ntot=80 /MaxReadThrough="1.24169" /MaxDrop="3.42621" /score="0.352684802" /energy="-11.5" /TU="NA" /idTUdmin="U1763" /TUdmin=3608 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1964083..1964102) /Source="Nicolas_upshift_promotors" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1964083) /Source="Nicolas_upshifts" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1964117..1964124) /Source="Nicolas_upshift_promotors" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1964162..1964608) /gene="ypiF" /locus_tag="BSU_22570" /old_locus_tag="BSU22570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15743949" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390138.1" /db_xref="EnsemblGenomes-Gn:BSU22570" /db_xref="EnsemblGenomes-Tr:CAB14173" /db_xref="InterPro:IPR019615" /db_xref="SubtiList:BG11498" /db_xref="UniProtKB/Swiss-Prot:P54391" /translation="MRWRITDAKDYLQAKDYIDTAVIPLINIRVNNHFKMAAEKGEFT QLLSEELERQLKGRVYLLPPYTYVDRNEITVQGLKDLREELITEFPHVVLLTSDESWR AEDALGKMIVTSSVPLEHLNDSLKRKILDERTAEILNVLLQLWSTL*" /label="ypiF CDS" gene complement(1964162..1964608) /gene="ypiF" /locus_tag="BSU_22570" /old_locus_tag="BSU22570" /label="ypiF gene" downshifts 1964611 /Source="Nicolas_upshifts" /id="D1179" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="0.94679" /MaxDrop="2.794" /score="0.352684802" /energy="-11.5" /TU="NA" /idTUdmin="U1763" /TUdmin=4191 /isTUend="FALSE" /label="downshifts" CDS complement(1964663..1965202) /gene="ypiB" /locus_tag="BSU_22580" /old_locus_tag="BSU22580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16847875" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390139.1" /db_xref="EnsemblGenomes-Gn:BSU22580" /db_xref="EnsemblGenomes-Tr:CAB14174" /db_xref="InterPro:IPR011188" /db_xref="InterPro:IPR014957" /db_xref="InterPro:IPR014963" /db_xref="SubtiList:BG11497" /db_xref="UniProtKB/Swiss-Prot:P54390" /translation="MQTPVSVNEKKDFIRWFLNHYQLKRRECVWILNYLMSHDSLMEK VHFVEQAEFCPRGIIMSTHCVEEVPFRFYKENVMTTDAEKSFHDIRLNKQQDLFIQLN FRSAYSSPEYAAVLESNPHIPKNLFENKKDQGLAEQILEHAISTFQREKLLKDIDDAL DRHDKEAFEQLSRQLNQLT*" /label="ypiB CDS" gene complement(1964663..1965202) /gene="ypiB" /locus_tag="BSU_22580" /old_locus_tag="BSU22580" /label="ypiB gene" downshifts complement(1964676) /Source="Nicolas_upshifts" /id="D1180" /incds=0 /nref=84 /ntot=250 /MaxReadThrough="5.68366" /MaxDrop="5.48142" /score="16.8021869" /energy="-11.2" /TU="U1766,U1767" /idTUdmin="U1768" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1965235..1965253) /Source="Nicolas_upshift_promotors" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="promotor_-10" upshifts complement(1965246) /Source="Nicolas_upshifts" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="upshifts" promotor_-35 complement(1965265..1965273) /Source="Nicolas_upshift_promotors" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="promotor_-35" CDS complement(1965274..1966545) /gene="ypiA" /locus_tag="BSU_22590" /old_locus_tag="BSU22590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390140.1" /db_xref="EnsemblGenomes-Gn:BSU22590" /db_xref="EnsemblGenomes-Tr:CAB14175" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11496" /db_xref="UniProtKB/Swiss-Prot:P54389" /translation="MNTLIQEAIKLVEAGETEKGLNTLSKAEKQLHDEDKAIAAQLYY EWGDVEKAISLISDLHDLYPNETELTNFYAELLIDIDEEEKALAVLETIPETDPSYPE SLLLMADLYQMQGLFEVSEQKLFQAKSILDNEPVIDFALGELYFAQGAYAKAVQYFKT TAEEQSEIGGVNVHQRLAESLSASGEFEDAIPWYEKAVDENPDPNTIFGYGFTALQAG LVKTAIKQLSDLKELDPSYTSLYMPLSKSYEAEGMYEEALKTAKEGIRYDEYNKELFL YAAKMALKIGKSEEGKKLLQEALALDPGFVEALHTLLAVYHKEEDYDQIIDLIQEVRS YGEEDPKYNWYLASAYTELEQYEEAKQSFEAAYLHYREDRDFLYEYASFLLEEGLQKE ALPLLKKVLEMDGANEELEETILRIEDEFSR*" /label="ypiA CDS" gene complement(1965274..1966545) /gene="ypiA" /locus_tag="BSU_22590" /old_locus_tag="BSU22590" /label="ypiA gene" S_feature complement(1966546..1966613) /Source="Nicolas_S_feature" /locus_tag="new_2367619_2367686_c" /HighExp="dia15, Diami, dia5, Etha, H2O2, T1.30H, LPhT, T0.30H, T3.0H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF, SigA" /TUshortPSig="0.999, 0.999, 0.999, 1" /TUlongSig="Sig-, Sig-, SigA, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.042, 0.047, 0.994, 0.999, 1, 0.999, 1, 0.998" /label="S855" promotor_-10 complement(1966610..1966629) /Source="Nicolas_upshift_promotors" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1966613) /Source="Nicolas_upshifts" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1966643..1966650) /Source="Nicolas_upshift_promotors" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1966680..1966699) /Source="Nicolas_upshift_promotors" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="promotor_-10" upshifts complement(1966686) /Source="Nicolas_upshifts" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="upshifts" S_feature complement(1966688..1966832) /Source="Nicolas_S_feature" /locus_tag="new_2367761_2367905_c" /HighExp="S3, LoTm, M9-stat, S4, Etha, S5, T5.0H, BT, B36, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, Sig-, SigA" /TUshortPSig="0.999, 1, 0.047, 0.994" /TUlongSig="Sig-, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.042, 0.999, 1, 0.999, 1, 0.998" /label="S856" promotor_-35 complement(1966710..1966717) /Source="Nicolas_upshift_promotors" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="promotor_-35" promotor_-10 complement(1966814..1966832) /Source="Nicolas_upshift_promotors" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-10" upshifts complement(1966832) /Source="Nicolas_upshifts" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="upshifts" promotor_-35 complement(1966848..1966853) /Source="Nicolas_upshift_promotors" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-35" CDS complement(1966881..1968167) /gene="aroA" /locus_tag="BSU_22600" /old_locus_tag="BSU22600" /EC_number="2.5.1.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3106153, 22938038, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvoylshikimate-3-phosphate synthase)" /protein_id="NP_390141.1" /db_xref="EnsemblGenomes-Gn:BSU22600" /db_xref="EnsemblGenomes-Tr:CAB14176" /db_xref="GOA:P20691" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR006264" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR023193" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG10294" /db_xref="UniProtKB/Swiss-Prot:P20691" /translation="MKRDKVQTLHGEIHIPGDKSISHRSVMFGALAAGTTTVKNFLPG ADCLSTIDCFRKMGVHIEQSSSDVVIHGKGIDALKEPESLLDVGNSGTTIRLMLGILA GRPFYSAVAGDESIAKRPMKRVTEPLKKMGAKIDGRAGGEFTPLSVSGASLKGIDYVS PVASAQIKSAVLLAGLQAEGTTTVTEPHKSRDHTERMLSAFGVKLSEDQTSVSIAGGQ KLTAADIFVPGDISSAAFFLAAGAMVPNSRIVLKNVGLNPTRTGIIDVLQNMGAKLEI KPSADSGAEPYGDLIIETSSLKAVEIGGDIIPRLIDEIPIIALLATQAEGTTVIKDAA ELKVKETNRIDTVVSELRKLGAEIEPTADGMKVYGKQTLKGGAAVSSHGDHRIGMMLG IASCITEEPIEIEHTDAIHVSYPTFFEHLNKLSKKS*" /label="aroA CDS" gene complement(1966881..1968167) /gene="aroA" /locus_tag="BSU_22600" /old_locus_tag="BSU22600" /label="aroA gene" downshifts complement(1966904) /Source="Nicolas_upshifts" /id="D1181" /incds=0 /nref=68 /ntot=212 /MaxReadThrough="3.64462" /MaxDrop="4.25336" /score="16.8021869" /energy="-11.2" /TU="U1770,U1772,U1773" /idTUdmin="U1775" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(1968178..1969293) /gene="tyrA" /locus_tag="BSU_22610" /old_locus_tag="BSU22610" /EC_number="1.3.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3106153, 3121591" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3106153, 3121591; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prephenate dehydrogenase" /protein_id="NP_390142.1" /db_xref="EnsemblGenomes-Gn:BSU22610" /db_xref="EnsemblGenomes-Tr:CAB14177" /db_xref="GOA:P20692" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR003099" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10293" /db_xref="UniProtKB/Swiss-Prot:P20692" /translation="MNQMKDTILLAGLGLIGGSIALAIKKNHPGKRIIGIDISDEQAV AALKLGVIDDRADSFISGVKEAATVIIATPVEQTLVMLEELAHSGIEHELLITDVGST KQKVVDYADQVLPSRYQFVGGHPMAGSHKSGVAAAKEFLFENAFYILTPGQKTDKQAV EQLKNLLKGTNAHFVEMSPEEHDGVTSVISHFPHIVAASLVHQTHHSENLYPLVKRFA AGGFRDITRIASSSPAMWRDILLHNKDKILDRFDEWIREIDKIRTYVEQEDAENLFRY FKTAKDYRDGLPLRQKGAIPAFYDLYVDVPDHPGVISEITAILAAERISITNIRIIET REDINGILRISFQSDDDRKRAEQCIEARAEYETFYAD*" /label="tyrA CDS" gene complement(1968178..1969293) /gene="tyrA" /locus_tag="BSU_22610" /old_locus_tag="BSU22610" /label="tyrA gene" CDS complement(1969342..1970424) /gene="hisC" /locus_tag="BSU_22620" /old_locus_tag="BSU22620" /EC_number="2.6.1.5" /EC_number="2.6.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4431, 418816, 824269, 11518529, 15102328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4431, 418816, 824269, 11518529, 15102328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol-phosphate aminotransferase; tyrosine/phenylalanine aminotransferase (promiscuous)" /protein_id="NP_390143.2" /db_xref="EnsemblGenomes-Gn:BSU22620" /db_xref="EnsemblGenomes-Tr:CAB14178" /db_xref="GOA:P17731" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR005861" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10292" /db_xref="UniProtKB/Swiss-Prot:P17731" /translation="MRIKEHLKQLKPYQPGKPIEAVKSEYGLDKVVKLASNENPYGCS EAAKEALHHEIQQLALYPDGYSAALRTRLSKHLNVSETSLIFGNGSDEIIQIICRAFL NDKTNTVTAAPTFPQYKHNAVIEGAEVREIALRPDGSHDLDAMLEAIDEQTQVVWICS PNNPTGTYTSEGELLAFLERVPSRVLVVLDEAYYEYVTAEDYPETVPLLSKYSNLMIL RTFSKAYGLAALRVGYGIADENLIRQIEPAREPFNTSRLGQAAAIAALDDQAFIASCV EQNNAGLQQYYDFAKTHGLKCYPSQTNFVLIDFKRPADELFQALLEKGYIVRSGNALG FPTSLRITIGTKEQNEEILAILAEIL*" /label="hisC CDS" gene complement(1969342..1970424) /gene="hisC" /locus_tag="BSU_22620" /old_locus_tag="BSU22620" /label="hisC gene" CDS complement(1970435..1971238) /gene="trpA" /locus_tag="BSU_22630" /old_locus_tag="BSU22630" /EC_number="4.2.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 10714985, 12963367, 17114058, 17555270" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 10714985, 12963367, 17114058, 17555270; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tryptophan synthase (alpha subunit)" /protein_id="NP_390144.1" /db_xref="EnsemblGenomes-Gn:BSU22630" /db_xref="EnsemblGenomes-Tr:CAB14179" /db_xref="GOA:P07601" /db_xref="InterPro:IPR002028" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018204" /db_xref="SubtiList:BG10291" /db_xref="UniProtKB/Swiss-Prot:P07601" /translation="MFKLDLQPSEKLFIPFITAGDPVPEVSIELAKSLQKAGATALEL GVAYSDPLADGPVIQRASKRALDQGMNIVKAIELGGEMKKNGVNIPIILFTYYNPVLQ LNKEYFFALLRENHIDGLLVPDLPLEESNSLQEECKSHEVTYISLVAPTSESRLKTII EQAEGFVYCVSSLGVTGVRNEFNSSVYPFIRTVKNLSTVPVAVGFGISNREQVIKMNE ISDGVVVGSALVRKIEELKDRLISAETRNQALQEFEDYAMAFSGLYSLK*" /label="trpA CDS" gene complement(1970435..1971238) /gene="trpA" /locus_tag="BSU_22630" /old_locus_tag="BSU22630" /label="trpA gene" promotor_-10 complement(1970923..1970942) /Source="Nicolas_upshift_promotors" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-10" upshifts complement(1970940) /Source="Nicolas_upshifts" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="upshifts" promotor_-35 complement(1970954..1970961) /Source="Nicolas_upshift_promotors" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-35" CDS complement(1971231..1972433) /gene="trpB" /locus_tag="BSU_22640" /old_locus_tag="BSU22640" /EC_number="4.2.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 3062311, 9383185, 10714985, 12963367, 17114058, 17555270" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 3062311, 9383185, 10714985, 12963367, 17114058, 17555270; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tryptophan synthase (beta subunit)" /protein_id="NP_390145.2" /db_xref="EnsemblGenomes-Gn:BSU22640" /db_xref="EnsemblGenomes-Tr:CAB14180" /db_xref="GOA:P07600" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR006653" /db_xref="InterPro:IPR006654" /db_xref="InterPro:IPR023026" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10290" /db_xref="UniProtKB/Swiss-Prot:P07600" /translation="MYPYPNEIGRYGDFGGKFVPETLMQPLDEIQTAFKQIKDDPAFR EEYYKLLKDYSGRPTALTYADRVTEYLGGAKIYLKREDLNHTGSHKINNALGQALLAK KMGKTKIIAETGAGQHGVAAATVAAKFGFSCTVFMGEEDVARQSLNVFRMKLLGAEVV PVTSGNGTLKDATNEAIRYWVQHCEDHFYMIGSVVGPHPYPQVVREFQKMIGEEAKDQ LKRIEGTMPDKVVACVGGGSNAMGMFQAFLNEDVELIGAEAAGKGIDTPLHAATISKG TVGVIHGSLTYLIQDEFGQIIEPYSISAGLDYPGIGPEHAYLHKSGRVTYDSITDEEA VDALKLLSEKEGILPAIESAHALAKAFKLAKGMDRGQLILVCLSGRGDKDVNTLMNVL EEEVKAHV*" /label="trpB CDS" gene complement(1971231..1972433) /gene="trpB" /locus_tag="BSU_22640" /old_locus_tag="BSU22640" /label="trpB gene" CDS complement(1972414..1973061) /gene="trpF" /locus_tag="BSU_22650" /old_locus_tag="BSU22650" /EC_number="5.3.1.24" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 10714985, 12963367, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 10714985, 12963367, 17114058; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylanthranilate isomerase" /protein_id="NP_390146.3" /db_xref="EnsemblGenomes-Gn:BSU22650" /db_xref="EnsemblGenomes-Tr:CAB14181" /db_xref="GOA:P20167" /db_xref="InterPro:IPR001240" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG10289" /db_xref="UniProtKB/Swiss-Prot:P20167" /translation="MKKPALKYCGIRSLKDLQLAAESQADYLGFIFAESKRKVSPEDV KKWLNQVRVEKQVAGVFVNESIETMSRIAKSLKLDVIQLHGDEKPADAAALRKLTGCE IWKALHHQDNTTQEIARFKDNVDGFVIDSSVKGSRGGTGVAFSWECVPEYQQAAIGKR CFIAGGVNPDSITRLLKWQPEGIDLASGIEKNGQKDQNLMRLLEERMNRYVSISE*" /label="trpF CDS" gene complement(1972414..1973061) /gene="trpF" /locus_tag="BSU_22650" /old_locus_tag="BSU22650" /label="trpF gene" downshifts complement(1972508) /Source="Nicolas_upshifts" /id="D1182" /incds=1 /nref=30 /ntot=83 /MaxReadThrough="8.17917" /MaxDrop="5.75867" /score="2.96963632" /energy="-11.9" /TU="U1771,U1772,U1773,U1775" /idTUdmin="U1774" /TUdmin=616 /isTUend="FALSE" /label="downshifts" misc_feature complement(1972684..1972687) /Source="Nicolas_upshift_promotors" /id="U1771" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.394605394605395" /psig="0.041958041958042" /xcortree=2849 /SigmaFactorBS="gcttcaccatcaagataacacaactcaagaaatagcccgctt taaagataatgttgaCGGCtttgtgattgattcatctgtaaaagggtctagaggcgga a" /listShort="trpB, trpA" /listLong="hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1972684) /Source="Nicolas_upshifts" /id="U1771" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.394605394605395" /psig="0.041958041958042" /xcortree=2849 /SigmaFactorBS="gcttcaccatcaagataacacaactcaagaaatagcccgctt taaagataatgttgaCGGCtttgtgattgattcatctgtaaaagggtctagaggcgga a" /listShort="trpB, trpA" /listLong="hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" downshifts complement(1972904) /Source="Nicolas_upshifts" /id="D1183" /incds=1 /nref=1 /ntot=84 /MaxReadThrough="8.55417" /MaxDrop="3.4408" /score="2.96963632" /energy="-11.9" /TU="U1772,U1773,U1775" /idTUdmin="U1774" /TUdmin=220 /isTUend="FALSE" /label="downshifts" misc_feature 1973066..1973818 /created_by="AR/SM" /id="IIG_Bs01" /note="due to the curing of the trpC2 locus (auxotrophy) of the Delta6 strain by transformation with chromosomal DNA from donor Bsu 3NA multiple snp`s were transferred to the oroginal trpC locus" /modified_by="User" /label="IIG_Bs01" /note="Geneious type: MiniBacillus__exchange" CDS complement(1973066..1973818) /locus_tag="PG10_trpC_var_BEP06_07765" /inference="EXISTENCE: similar to AA sequence:RefSeq:WP_007409461.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="indole-3-glycerol phosphate synthase" /protein_id="ANY35339.1" /old_locus_tag="BSU_22660" /gene="trpC" /modified_by="User" /translation="MLEKIIKQKKEEVKTLVLPVEQPFEKRSFKEALASLNRFIGLIA EVKKASPSKGLIKENFVPVRIAKDYETAKADALSVLTDTPFFQGENSYLSDVKRAVSI PVLRKDFIIDSLQVEESRRIGADAILLIGEVLDPLHLHELYLEAGEKEMDVLVEVHDA TTLEQILKVFTPDILGINNRNLKTFETSIMQTEQIASLAPKESLLVSESGIGSLEHLT FVKEHGARAVLIGESLMRQTSQRKAIHALFRE*" /label="PG10_trpC_var_BEP06_07765" gene complement(1973066..1973818) /locus_tag="PG10_trpC_var_BEP06_07765" /old_locus_tag="BSU_22660" /gene="trpC" /modified_by="User" /label="PG10_trpC_var_BEP06_07765" misc_feature complement(1973099..1973101) /Source="Nicolas_upshift_promotors" /id="U1772" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.43956043956044" /psig="0.046953046953047" /xcortree=2850 /SigmaFactorBS="tgtcaatgaacatggggcgcgagctgtacttatcggtgaatc attgatgagacaaacttctCAGcgtaaagcaatccatgctttgtttagggagtgaggt t" /listShort="trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1973102 /Source="Nicolas_upshifts" /id="U1772" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.43956043956044" /psig="0.046953046953047" /xcortree=2850 /SigmaFactorBS="tgtcaatgaacatggggcgcgagctgtacttatcggtgaatc attgatgagacaaacttctCAGcgtaaagcaatccatgctttgtttagggagtgaggt t" /listShort="trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="upshifts" Polymorphism join(1973208,1973211) /Source="geneious" /ID="SNP_BsPG10_2374282_2374283" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=2 /Amino_Acid_Change /CDS_Position=606 /Change="AG -> GT" /Codon_Change="TCC,TTG -> TCA,CTG" /Coverage="129 -> 130" /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="AG" /Variant_Nucleotides="GT" /Variant_P_Value="2e-203" /Variant_Raw_Frequency="128 -> 129" /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1973222,1973224) /Source="geneious" /ID="SNP_BsPG10_2374296_2374296" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="V -> A" /CDS_Position=593 /Change="A -> G" /Codon_Change="GTT -> GCT" /Coverage=119 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="3.2e-179" /Variant_Raw_Frequency=119 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1973224,1973226) /Source="geneious" /ID="SNP_BsPG10_2374298_2374298" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=591 /Change="G -> A" /Codon_Change="CTC -> CTT" /Coverage=118 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value="9.9e-148" /Variant_Raw_Frequency=116 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1973249,1973251) /Source="geneious" /ID="SNP_BsPG10_2374323_2374323" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="K -> M" /CDS_Position=566 /Change="T -> A" /Codon_Change="AAG -> ATG" /Coverage=81 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="A" /Variant_P_Value="6.3e-98" /Variant_Raw_Frequency=81 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1973251,1973255) /Source="geneious" /ID="SNP_BsPG10_2374325_2374327" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=2 /Amino_Acid_Change="V -> I" /CDS_Position=562 /Change="TAC -> GAT" /Codon_Change="GTA -> ATC" /Coverage="79 -> 84" /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="TAC" /Variant_Nucleotides="GAT" /Variant_P_Value="2.3e-77" /Variant_Raw_Frequency="74 -> 78" /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1973257,1973259) /Source="geneious" /ID="SNP_BsPG10_2374331_2374331" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=558 /Change="T -> G" /Codon_Change="ACA -> ACC" /Coverage=70 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="G" /Variant_P_Value="1e-63" /Variant_Raw_Frequency=70 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1973266,1973268) /Source="geneious" /ID="SNP_BsPG10_2374340_2374340" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=549 /Change="C -> A" /Codon_Change="ACG -> ACT" /Coverage=59 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="A" /Variant_P_Value="1e-59" /Variant_Raw_Frequency=59 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1973281,1973283) /Source="geneious" /ID="SNP_BsPG10_2374355_2374355" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=534 /Change="A -> G" /Codon_Change="AAT -> AAC" /Coverage=66 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="6e-64" /Variant_Raw_Frequency=65 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1973284,1973286) /Source="geneious" /ID="SNP_BsPG10_2374358_2374358" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=531 /Change="A -> G" /Codon_Change="AAT -> AAC" /Coverage=63 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="3.3e-68" /Variant_Raw_Frequency=60 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1973289,1973291) /Source="geneious" /ID="SNP_BsPG10_2374363_2374363" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="V -> I" /CDS_Position=526 /Change="C -> T" /Codon_Change="GTA -> ATA" /Coverage=65 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="3.9e-82" /Variant_Raw_Frequency=64 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1973299,1973301) /Source="geneious" /ID="SNP_BsPG10_2374373_2374373" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=516 /Change="G -> A" /Codon_Change="GAC -> GAT" /Coverage=79 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value="7.7e-116" /Variant_Raw_Frequency=78 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1973302,1973304) /Source="geneious" /ID="SNP_BsPG10_2374376_2374376" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=513 /Change="G -> A" /Codon_Change="CCC -> CCT" /Coverage=92 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value="4e-141" /Variant_Raw_Frequency=90 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1973305,1973307) /Source="geneious" /ID="SNP_BsPG10_2374379_2374379" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=510 /Change="T -> C" /Codon_Change="ACA -> ACG" /Coverage=97 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="1.3e-165" /Variant_Raw_Frequency=97 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1973311,1973313) /Source="geneious" /ID="SNP_BsPG10_2374385_2374385" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=504 /Change="C -> T" /Codon_Change="GTG -> GTA" /Coverage=109 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="4.3e-193" /Variant_Raw_Frequency=108 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1973337,1973339) /Source="geneious" /ID="SNP_BsPG10_2374411_2374411" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="S -> T" /CDS_Position=478 /Change="A -> T" /Codon_Change="TCA -> ACA" /Coverage=148 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="T" /Variant_P_Value="2.9e-307" /Variant_Raw_Frequency=147 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1973369,1973371) /Source="geneious" /ID="SNP_BsPG10_2374443_2374443" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="G -> E" /CDS_Position=446 /Change="C -> T" /Codon_Change="GGG -> GAG" /Coverage=161 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=161 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1973422,1973424) /Source="geneious" /ID="SNP_BsPG10_2374496_2374496" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=393 /Change="C -> T" /Codon_Change="GAG -> GAA" /Coverage=174 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=174 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1973470,1973472) /Source="geneious" /ID="SNP_BsPG10_2374544_2374544" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=345 /Change="T -> C" /Codon_Change="GTA -> GTG" /Coverage=168 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=167 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1973485,1973489) /Source="geneious" /ID="SNP_BsPG10_2374559_2374558" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=0 /Amino_Acid_Change="-> I" /CDS_Position=331 /Change="AAT" /Codon_Change="-> ATT" /Coverage=164 /locus_tag="BSU_22660" /Protein_Effect="Insertion" /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="AAT" /Variant_P_Value="3.90000001038273e-316" /Variant_Raw_Frequency=147 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1973503,1973505) /Source="geneious" /ID="SNP_BsPG10_2374574_2374574" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=315 /Change="A -> G" /Codon_Change="CTT -> CTC" /Coverage=155 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value=0 /Variant_Raw_Frequency=154 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1973512,1973514) /Source="geneious" /ID="SNP_BsPG10_2374583_2374583" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=306 /Change="A -> T" /Codon_Change="ATT -> ATA" /Coverage=153 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=152 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1973524,1973526) /Source="geneious" /ID="SNP_BsPG10_2374595_2374595" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=294 /Change="A -> G" /Codon_Change="CGT -> CGC" /Coverage=128 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="4e-295" /Variant_Raw_Frequency=128 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1973589,1973591) /Source="geneious" /ID="SNP_BsPG10_2374660_2374660" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="I -> L" /CDS_Position=229 /Change="T -> G" /Codon_Change="ATT -> CTT" /Coverage=131 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="G" /Variant_P_Value="2.3e-302" /Variant_Raw_Frequency=128 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1973599,1973601) /Source="geneious" /ID="SNP_BsPG10_2374670_2374670" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=219 /Change="C -> T" /Codon_Change="AAG -> AAA" /Coverage=126 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="1.6e-290" /Variant_Raw_Frequency=126 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1973607,1973610) /Source="geneious" /ID="SNP_BsPG10_2374678_2374679" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=2 /Amino_Acid_Change="EA -> ET" /CDS_Position=210 /Change="CC -> TT" /Codon_Change="GAG,GCT -> GAA,ACT" /Coverage="124 -> 130" /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="CC" /Variant_Nucleotides="TT" /Variant_P_Value="4.7e-253" /Variant_Raw_Frequency="119 -> 125" /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1973627,1973629) /Source="geneious" /ID="SNP_BsPG10_2374698_2374698" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="Q -> R" /CDS_Position=191 /Change="T -> C" /Codon_Change="CAG -> CGG" /Coverage=104 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="9e-228" /Variant_Raw_Frequency=101 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1973643,1973645) /Source="geneious" /ID="SNP_BsPG10_2374714_2374714" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="D -> N" /CDS_Position=175 /Change="C -> T" /Codon_Change="GAT -> AAT" /Coverage=95 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency="1.1%" /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="2.8e-220" /Variant_Raw_Frequency=93 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1973671,1973673) /Source="geneious" /ID="SNP_BsPG10_2374742_2374742" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=147 /Change="T -> C" /Codon_Change="GCA -> GCG" /Coverage=98 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="1.2e-260" /Variant_Raw_Frequency=97 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1973686,1973688) /Source="geneious" /ID="SNP_BsPG10_2374757_2374757" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=132 /Change="G -> A" /Codon_Change="GCC -> GCT" /Coverage=197 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value /Variant_Raw_Frequency /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1973711,1973713) /Source="geneious" /ID="SNP_BsPG10_2374782_2374782" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="P -> L" /CDS_Position=107 /Change="G -> A" /Codon_Change="CCG -> CTG" /Coverage=118 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value=0 /Variant_Raw_Frequency=118 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1973728,1973730) /Source="geneious" /ID="SNP_BsPG10_2374799_2374799" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=90 /Change="C -> T" /Codon_Change="AAG -> AAA" /Coverage=133 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=131 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1973743,1973745) /Source="geneious" /ID="SNP_BsPG10_2374814_2374814" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=75 /Change="C -> T" /Codon_Change="GAG -> GAA" /Coverage=130 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=130 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" CDS complement(1973811..1974827) /gene="trpD" /locus_tag="BSU_22670" /old_locus_tag="BSU22670" /EC_number="2.4.2.18" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 17555270, 10714985, 12963367, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 17555270, 10714985, 12963367, 17114058; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="anthranilate phosphoribosyltransferase" /protein_id="NP_390148.2" /db_xref="EnsemblGenomes-Gn:BSU22670" /db_xref="EnsemblGenomes-Tr:CAB14183" /db_xref="GOA:P03947" /db_xref="InterPro:IPR000312" /db_xref="InterPro:IPR005940" /db_xref="InterPro:IPR017459" /db_xref="InterPro:IPR035902" /db_xref="InterPro:IPR036320" /db_xref="SubtiList:BG10288" /db_xref="UniProtKB/Swiss-Prot:P03947" /modified_by="User" /translation="MNRFLQLCVDGKTLTAGEAETLMNMMMAAEMTPSEMGGILSILA HRGETPEELAGFVKAMRAHALTVDGLPDIVDTCGTGGDGISTFNISTASAIVASAAGA KIAKHGNRSVSSKSGSADVLEELEVSIQTTPEKVKSSIETNNMGFLFAPLYHSSMKHV AGTRKELGFRTVFNLLGPLSNPLQAKRQVIGVYSVEKAGLMASALETFQPKHVMFVSS RDGLDELSITAPTDVIELKDGERREYTVSPEDFGFTNGRLEDLQVQSPKESAYLIQNI FENKSSSSALSITAFNAGAAIYTAGITASLKEGTELALETITSGGAAAQLERLKQKEE EIYA*" /label="trpD CDS" gene complement(1973811..1974827) /gene="trpD" /locus_tag="BSU_22670" /old_locus_tag="BSU22670" /modified_by="User" /label="trpD gene" CDS complement(1974799..1976346) /gene="trpE" /locus_tag="BSU_22680" /old_locus_tag="BSU22680" /EC_number="4.1.3.27" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 17555270, 10714985, 12963367, 15063849, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 17555270, 10714985, 12963367, 15063849, 17114058; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="anthranilate synthase" /protein_id="NP_390149.1" /db_xref="EnsemblGenomes-Gn:BSU22680" /db_xref="EnsemblGenomes-Tr:CAB14184" /db_xref="GOA:P03963" /db_xref="InterPro:IPR005256" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR006805" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR019999" /db_xref="SubtiList:BG10287" /db_xref="UniProtKB/Swiss-Prot:P03963" /translation="MNFQSNISAFLEDSLSHHTIPIVETFTVDTLTPIQMIEKLDREI TYLLESKDDTSTWSRYSFIGLNPFLTIKEEQGRFSAADQDSKSLYTGNELKEVLNWMN TTYKIKTPELGIPFVGGAVGYLSYDMIPLIEPSVPSHTKETDMEKCMLFVCRTLIAYD HETKNVHFIQYARLTGEETKNEKMDVFHQNHLELQNLIEKMMDQKNIKELFLSADSYK TPSFETVSSNYEKSAFMADVEKIKSYIKAGDIFQGVLSQKFEVPIKADAFELYRVLRI VNPSPYMYYMKLLDREIVGSSPERLIHVQDGHLEIHPIAGTRKRGADKAEDERLKVEL MKDEKEKAEHYMLVDLARNDIGRVAEYGSVSVPEFTKIVSFSHVMHIISVVTGRLKKG VHPVDALMSAFPAGTLTGAPKIRAMQLLQELEPTPRETYGGCIAYIGFDGNIDSCITI RTMSVKNGVASIQAGAGIVADSVPEAEYEESCNKAGALLKTIHIAEDMFHSKEDKADE QISTIVR*" /label="trpE CDS" gene complement(1974799..1976346) /gene="trpE" /locus_tag="BSU_22680" /old_locus_tag="BSU22680" /label="trpE gene" S_feature complement(1976425..1976556) /Source="Nicolas_S_feature" /locus_tag="new_2377495_2377626_c" /HighExp="Etha, S1, GM 25, GM 15, HiTm, Glu, MG-0.1, GM 60, M9-exp, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY, SigA, SigA, SigA" /TUshortPSig="0.994, 0.647, 0.999, 1, 0.996" /TUlongSig="SigA, SigA, SigA" /TUlongPSig="0.999, 1, 0.998" /label="S857" downshifts complement(1976468) /Source="Nicolas_upshifts" /id="D1184" /incds=0 /nref=61 /ntot=157 /MaxReadThrough="7.41666" /MaxDrop="5.25158" /score="2.96963632" /energy="-11.9" /TU="U1773,U1774,U1775,U1776" /idTUdmin="U1777" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1976547..1976566) /Source="Nicolas_upshift_promotors" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_-10" upshifts complement(1976556) /Source="Nicolas_upshifts" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="upshifts" CDS complement(1976562..1976945) /gene="aroH" /locus_tag="BSU_22690" /old_locus_tag="BSU22690" /EC_number="5.4.99.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2105742, 8378335, 9384560, 10818343, 15865424, 16060652, 28743924" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2105742, 8378335, 9384560, 10818343, 15865424, 16060652, 28743924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chorismate mutase" /protein_id="NP_390150.1" /db_xref="EnsemblGenomes-Gn:BSU22690" /db_xref="EnsemblGenomes-Tr:CAB14185" /db_xref="GOA:P19080" /db_xref="InterPro:IPR008243" /db_xref="InterPro:IPR035959" /db_xref="PDB:1COM" /db_xref="PDB:1DBF" /db_xref="PDB:1FNJ" /db_xref="PDB:1FNK" /db_xref="PDB:2CHS" /db_xref="PDB:2CHT" /db_xref="PDB:3ZO8" /db_xref="PDB:3ZOP" /db_xref="PDB:3ZP4" /db_xref="PDB:3ZP7" /db_xref="SubtiList:BG10286" /db_xref="UniProtKB/Swiss-Prot:P19080" /translation="MMIRGIRGATTVERDTEEEILQKTKQLLEKIIEENHTKPEDVVQ MLLSATPDLHAVFPAKAVRELSGWQYVPVTCMQEMDVTGGLKKCIRVMMTVQTDVPQD QIRHVYLEKVVVLRPDLSLTKNTEL*" /label="aroH CDS" gene complement(1976562..1976945) /gene="aroH" /locus_tag="BSU_22690" /old_locus_tag="BSU22690" /label="aroH gene" promotor_-35 complement(1976581..1976588) /Source="Nicolas_upshift_promotors" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_-35" CDS complement(1976942..1978030) /gene="aroB" /locus_tag="BSU_22700" /old_locus_tag="BSU22700" /EC_number="4.2.3.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:97285, 97286, 6795181, 24628944" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 97285, 97286, 6795181, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate synthase" /protein_id="NP_390151.1" /db_xref="EnsemblGenomes-Gn:BSU22700" /db_xref="EnsemblGenomes-Tr:CAB14186" /db_xref="GOA:P31102" /db_xref="InterPro:IPR016037" /db_xref="InterPro:IPR030960" /db_xref="InterPro:IPR030963" /db_xref="SubtiList:BG10285" /db_xref="UniProtKB/Swiss-Prot:P31102" /translation="MKTLHVQTASSSYPVFIGQGIRKKACELLTSLNRPLTRIMFVTD EEVDRLYGDEMLHLLQEKWPVKKVTVPSGEQAKSMDMYTKLQSEAIRFHMDRSSCIIA FGGGVVGDLAGFVAATFMRGIDFIQMPTTLLAHDSAVGGKVAVNHPLGKNLIGAFYQP KAVLYDTDFLRSLPEKELRSGMAEVIKHAFIYDRAFLEELLNIHSLRDITNDQLNDMI FKGISIKASVVQQDEKEEGIRAYLNFGHTLGHAVEAEYGYGQITHGDAVALGMQFALY ISEKTVGCEMDRKRLVSWLKSLGYPSQIRKETETSVLLNRMMNDKKTRGGKIQFIVLN ELGKVADHTFSRNELESWLNKWRLEETS*" /label="aroB CDS" gene complement(1976942..1978030) /gene="aroB" /locus_tag="BSU_22700" /old_locus_tag="BSU22700" /label="aroB gene" promotor_-10 complement(1977071..1977086) /Source="Nicolas_upshift_promotors" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-10" upshifts complement(1977084) /Source="Nicolas_upshifts" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="upshifts" promotor_-35 complement(1977099..1977107) /Source="Nicolas_upshift_promotors" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-35" CDS complement(1978030..1979202) /gene="aroF" /locus_tag="BSU_22710" /old_locus_tag="BSU22710" /EC_number="4.2.3.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:97285, 97286, 6795181, 10518299, 24628944" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 97285, 97286, 6795181, 10518299, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chorismate synthase" /protein_id="NP_390152.3" /db_xref="EnsemblGenomes-Gn:BSU22710" /db_xref="EnsemblGenomes-Tr:CAB14187" /db_xref="GOA:P31104" /db_xref="InterPro:IPR000453" /db_xref="InterPro:IPR020541" /db_xref="InterPro:IPR035904" /db_xref="SubtiList:BG10284" /db_xref="UniProtKB/Swiss-Prot:P31104" /translation="MRYLTAGESHGPQLTTIIEGVPAGLYITEEDINFELARRQKGHG RGRRMQIEKDQAKIMSGVRHARTLGSPIALVVENNDWKHWTKIMGAAPITEDEEKEMK RQISRPRPGHADLNGAIKYNHRDMRNVLERSSARETTVRVAAGAVAKKILSELGIKVA GHVLQIGAVKAEKTEYTSIEDLQRVTEESPVRCYDEEAGKKMMAAIDEAKANGDSIGG IVEVIVEGMPVGVGSYVHYDRKLDSKLAAAVLSINAFKGVEFGIGFEAAGRNGSEVHD EIIWDEEKGYTRATNRLGGLEGGMTTGMPIVVRGVMKPIPTLYKPLKSVDIETKEPFS ASIERSDSCAVPAASVVAEAAVAWEIANAVVEQFGLDQIDRIRENVENMRKLSREF*" /label="aroF CDS" gene complement(1978030..1979202) /gene="aroF" /locus_tag="BSU_22710" /old_locus_tag="BSU22710" /label="aroF gene" promotor_-10 complement(1979237..1979256) /Source="Nicolas_upshift_promotors" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1979254) /Source="Nicolas_upshifts" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(1979269..1979276) /Source="Nicolas_upshift_promotors" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(1979277..1980047) /gene="cheR" /locus_tag="BSU_22720" /old_locus_tag="BSU22720" /EC_number="2.1.1.80" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7635819, 7893679, 8244966, 10196193, 15544802, 25799883, 27544050" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7635819, 7893679, 8244966, 10196193, 15544802, 25799883, 27544050; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis proteins (MCPs) methyltransferase" /protein_id="NP_390153.2" /db_xref="EnsemblGenomes-Gn:BSU22720" /db_xref="EnsemblGenomes-Tr:CAB14188" /db_xref="GOA:P31105" /db_xref="InterPro:IPR000780" /db_xref="InterPro:IPR022641" /db_xref="InterPro:IPR022642" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036804" /db_xref="PDB:5FTW" /db_xref="SubtiList:BG10283" /db_xref="UniProtKB/Swiss-Prot:P31105" /translation="MDTYSVFTTKWKQLTGVDLTLYKEAQMKRRLTSLYEKKGFQSFK DFAAALEKDQALLNETLDRMTINVSEFYRNYKRWEVLETAILPLIKTSRPLKIWSAAC STGEEPYTLAMLLDQQKGLPGYQILATDIDEKALEKAKKGVYQERSLQEVPLSVKDRY FTQNANRSYEVKTEIKKNITFKKHNLLADRYEQDFDLIVCRNVFIYFTESAKEELYLK MAHSLKKNGVLFVGSTEQIFNPEKFGLVPADTFFYQKR*" /label="cheR CDS" gene complement(1979277..1980047) /gene="cheR" /locus_tag="BSU_22720" /old_locus_tag="BSU22720" /label="cheR gene" promotor_-10 complement(1980073..1980092) /Source="Nicolas_upshift_promotors" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1980090) /Source="Nicolas_upshifts" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(1980104..1980110) /Source="Nicolas_upshift_promotors" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" S_feature complement(1980122..1980283) /Source="Nicolas_S_feature" /locus_tag="new_2381192_2381353_c" /HighExp="M0t90, Lbstat, S0, Mt0, M0t45, M40t90, Lbtran, Mal, G/S, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.996, 0.999, 1, 0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S858" downshifts complement(1980165) /Source="Nicolas_upshifts" /id="D1185" /incds=0 /nref=26 /ntot=128 /MaxReadThrough="4.04342" /MaxDrop="4.7493" /score="29.2259705" /energy="-8.6" /TU="U1777,U1778,U1779,U1780" /idTUdmin="U1778" /TUdmin="-880" /isTUend="FALSE" /label="downshifts" CDS complement(1980284..1980733) /gene="ndk" /locus_tag="BSU_22730" /old_locus_tag="BSU22730" /EC_number="2.7.4.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9179491, 11734624, 22720735, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nucleoside diphosphate kinase" /protein_id="NP_390154.1" /db_xref="EnsemblGenomes-Gn:BSU22730" /db_xref="EnsemblGenomes-Tr:CAB14189" /db_xref="GOA:P31103" /db_xref="InterPro:IPR001564" /db_xref="InterPro:IPR023005" /db_xref="InterPro:IPR034907" /db_xref="InterPro:IPR036850" /db_xref="SubtiList:BG10282" /db_xref="UniProtKB/Swiss-Prot:P31103" /translation="MMEKTFIMVKPDGVQRQLIGDILSRFERKGLQLAGAKLMRVTEQ MAEKHYAEHQGKPFFGELVEFITSGPVFAMVWEGENVIEVTRQLIGKTNPKEALPGTI RGDYGMFVGKNIIHGSDSLESAEREINIFFKNEELVSYQQLMAGWIY*" /label="ndk CDS" gene complement(1980284..1980733) /gene="ndk" /locus_tag="BSU_22730" /old_locus_tag="BSU22730" /label="ndk gene" promotor_-10 complement(1980776..1980795) /Source="Nicolas_upshift_promotors" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-10" upshifts complement(1980783) /Source="Nicolas_upshifts" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="upshifts" promotor_-35 complement(1980808..1980815) /Source="Nicolas_upshift_promotors" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-35" CDS complement(1980849..1981895) /gene="hepT" /locus_tag="BSU_22740" /old_locus_tag="BSU22740" /EC_number="2.5.1.30" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6768722, 9139683, 9720033, 9756625, 10545188, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6768722, 9139683, 9720033, 9756625, 10545188, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heptaprenyl diphosphate synthase component II" /protein_id="NP_390155.1" /db_xref="EnsemblGenomes-Gn:BSU22740" /db_xref="EnsemblGenomes-Tr:CAB14190" /db_xref="GOA:P31114" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR014119" /db_xref="InterPro:IPR033749" /db_xref="SubtiList:BG10281" /db_xref="UniProtKB/Swiss-Prot:P31114" /translation="MLNIIRLLAESLPRISDGNENTDVWVNDMKFKMAYSFLNDDIDV IERELEQTVRSDYPLLSEAGLHLLQAGGKRIRPVFVLLSGMFGDYDINKIKYVAVTLE MIHMASLVHDDVIDDAELRRGKPTIKAKWDNRIAMYTGDYMLAGSLEMMTRINEPKAH RILSQTIVEVCLGEIEQIKDKYNMEQNLRTYLRRIKRKTALLIAVSCQLGAIASGADE KIHKALYWFGYYVGMSYQIIDDILDFTSTEEELGKPVGGDLLQGNVTLPVLYALKNPA LKNQLKLINSETTQEQLEPIIEEIKKTDAIEASMAVSEMYLQKAFQKLNTLPRGRARS SLAAIAKYIGKRKF*" /label="hepT CDS" gene complement(1980849..1981895) /gene="hepT" /locus_tag="BSU_22740" /old_locus_tag="BSU22740" /label="hepT gene" CDS complement(1981837..1982538) /gene="menG" /locus_tag="BSU_22750" /old_locus_tag="BSU22750" /EC_number="2.1.1.163" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16279806, 9045837, 9139683, 21513522, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16279806, 9045837, 9139683, 21513522, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="demethylmenaquinone methyltransferase" /protein_id="NP_390156.1" /db_xref="EnsemblGenomes-Gn:BSU22750" /db_xref="EnsemblGenomes-Tr:CAB14191" /db_xref="GOA:P31113" /db_xref="InterPro:IPR004033" /db_xref="InterPro:IPR014122" /db_xref="InterPro:IPR023576" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10280" /db_xref="UniProtKB/Swiss-Prot:P31113" /translation="MQDSKEQRVHGVFEKIYKNYDQMNSVISFQQHKKWRDKTMRIMN VKEGAKALDVCCGTADWTIALAKAAGKSGEIKGLDFSENMLSVGEQKVKDGGFSQIEL LHGNAMELPFDDDTFDYVTIGFGLRNVPDYLTVLKEMRRVVKPGGQVVCLETSQPEMF GFRQAYFMYFKYIMPFFGKLFAKSYKEYSWLQESARDFPGMKELAGLFEEAGLKNVKY HSFTGGVAATHIGWK*" /label="menG CDS" gene complement(1981837..1982538) /gene="menG" /locus_tag="BSU_22750" /old_locus_tag="BSU22750" /label="menG gene" CDS complement(1982545..1983300) /gene="hepS" /locus_tag="BSU_22760" /old_locus_tag="BSU22760" /EC_number="2.5.1.30" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6768722, 9139683, 9720033, 9756625, 10545188, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6768722, 9139683, 9720033, 9756625, 10545188, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heptaprenyl diphosphate synthase component I" /protein_id="NP_390157.1" /db_xref="EnsemblGenomes-Gn:BSU22760" /db_xref="EnsemblGenomes-Tr:CAB14192" /db_xref="GOA:P31112" /db_xref="InterPro:IPR009920" /db_xref="SubtiList:BG10279" /db_xref="UniProtKB/Swiss-Prot:P31112" /translation="MQDIYGTLANLNTKLKQKLSHPYLAKHISAPKIDEDKLLLFHAL FEEADIKNNDRENYIVTAMLVQSALDTHDEVTTARVIKRDENKNRQLTVLAGDYFSGL YYSLLSEMKDIYMIRTLATAIKEINEHKIRLYDRSFKDENDFFESVGIVESALFHRVA EHFNLPRWKKLSSDFFVFKRLMNGNDAFLDVIGSFIQLGKTKEEILEDCFKKAKNSIE SLLPLNSPIQNILINRLKTISQDQTYHQKVEEG*" /label="hepS CDS" gene complement(1982545..1983300) /gene="hepS" /locus_tag="BSU_22760" /old_locus_tag="BSU22760" /label="hepS gene" S_feature complement(1983301..1983386) /Source="Nicolas_S_feature" /locus_tag="new_2384371_2384456_c" /HighExp="H2O2, G150, G180, Paraq, Oxctl, G135, T-4.40H, Lbexp, T-3.40H, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 1, 0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S859" promotor_-10 complement(1983375..1983394) /Source="Nicolas_upshift_promotors" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1983386) /Source="Nicolas_upshifts" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(1983405..1983412) /Source="Nicolas_upshift_promotors" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(1983464..1983691) /gene="mtrB" /locus_tag="BSU_22770" /old_locus_tag="BSU22770" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15099736, 15588817, 16285852, 16306262, 17114058, 28069823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15099736, 15588817, 16285852, 16306262, 17114058, 28069823; Product type r : regulator" /codon_start=1 /transl_table=11 /product="tryptophan operon RNA-binding attenuation protein (TRAP)" /protein_id="NP_390158.1" /db_xref="EnsemblGenomes-Gn:BSU22770" /db_xref="EnsemblGenomes-Tr:CAB14193" /db_xref="GOA:P19466" /db_xref="InterPro:IPR000824" /db_xref="InterPro:IPR016031" /db_xref="InterPro:IPR023558" /db_xref="PDB:1WAP" /db_xref="PDB:3ZZQ" /db_xref="PDB:4B27" /db_xref="SubtiList:BG10278" /db_xref="UniProtKB/Swiss-Prot:P19466" /translation="MNQKHSSDFVVIKAVEDGVNVIGLTRGTDTKFHHSEKLDKGEVI IAQFTEHTSAIKVRGEALIQTAYGEMKSEKK*" /label="mtrB CDS" gene complement(1983464..1983691) /gene="mtrB" /locus_tag="BSU_22770" /old_locus_tag="BSU22770" /label="mtrB gene" downshifts complement(1983485) /Source="Nicolas_upshifts" /id="D1186" /incds=0 /nref=22 /ntot=162 /MaxReadThrough="6.02348" /MaxDrop="4.385" /score="8.50521108" /energy="-10.5" /TU="U1779,U1780" /idTUdmin="U1781" /TUdmin=1499 /isTUend="FALSE" /label="downshifts" CDS complement(1983713..1984285) /gene="folEA" /locus_tag="BSU_22780" /old_locus_tag="BSU22780" /EC_number="3.5.4.16" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1551827, 12559918, 14717702, 17032654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1551827, 12559918, 14717702, 17032654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP cyclohydrolase I" /protein_id="NP_390159.1" /db_xref="EnsemblGenomes-Gn:BSU22780" /db_xref="EnsemblGenomes-Tr:CAB14194" /db_xref="GOA:P19465" /db_xref="InterPro:IPR001474" /db_xref="InterPro:IPR018234" /db_xref="InterPro:IPR020602" /db_xref="SubtiList:BG10277" /db_xref="UniProtKB/Swiss-Prot:P19465" /translation="MKEVNKEQIEQAVRQILEAIGEDPNREGLLDTPKRVAKMYAEVF SGLNEDPKEHFQTIFGENHEELVLVKDIAFHSMCEHHLVPFYGKAHVAYIPRGGKVTG LSKLARAVEAVAKRPQLQERITSTIAESIVETLDPHGVMVVVEAEHMCMTMRGVRKPG AKTVTSAVRGVFKDDAAARAEVLEHIKRQD*" /label="folEA CDS" gene complement(1983713..1984285) /gene="folEA" /locus_tag="BSU_22780" /old_locus_tag="BSU22780" /label="folEA gene" promotor_-10 complement(1984314..1984333) /Source="Nicolas_upshift_promotors" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1984324) /Source="Nicolas_upshifts" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" S_feature complement(1984326..1984409) /Source="Nicolas_S_feature" /locus_tag="new_2385396_2385479_c" /HighExp="Oxctl, G150, G180, G135, LBGexp, Paraq, LPh, H2O2, aero, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S860" promotor_-35 complement(1984346..1984352) /Source="Nicolas_upshift_promotors" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" downshifts complement(1984454) /Source="Nicolas_upshifts" /id="D1187" /incds=0 /nref=33 /ntot=254 /MaxReadThrough="6.68474" /MaxDrop="5.1938" /score="8.50521108" /energy="-10.5" /TU="U1780" /idTUdmin="U1781" /TUdmin=530 /isTUend="FALSE" /label="downshifts" CDS complement(1984473..1984751) /gene="hbs" /locus_tag="BSU_22790" /old_locus_tag="BSU22790" /function="16.1: Circulate" /function="16.3: Control" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:1382620, 9106208, 10224127, 10231583, 10715001, 11931565, 19210617" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1382620, 9106208, 10224127, 10231583, 10715001, 11931565, 19210617; Product type f: factor" /codon_start=1 /transl_table=11 /product="non-specific DNA-binding protein HBsu" /protein_id="NP_390160.1" /db_xref="EnsemblGenomes-Gn:BSU22790" /db_xref="EnsemblGenomes-Tr:CAB14195" /db_xref="GOA:P08821" /db_xref="InterPro:IPR000119" /db_xref="InterPro:IPR010992" /db_xref="InterPro:IPR020816" /db_xref="SubtiList:BG10276" /db_xref="UniProtKB/Swiss-Prot:P08821" /translation="MNKTELINAVAEASELSKKDATKAVDSVFDTILDALKNGDKIQL IGFGNFEVRERSARKGRNPQTGEEIEIPASKVPAFKPGKALKDAVAGK*" /label="hbs CDS" gene complement(1984473..1984751) /gene="hbs" /locus_tag="BSU_22790" /old_locus_tag="BSU22790" /label="hbs gene" S_feature complement(1984752..1984977) /Source="Nicolas_S_feature" /locus_tag="new_2385822_2386047_c" /HighExp="dia5, C90, T-0.40H, G/S, S1, Salt, Lbexp, dia15, T-1.40H, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S861" promotor_-10 complement(1984959..1984978) /Source="Nicolas_upshift_promotors" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1984977) /Source="Nicolas_upshifts" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(1984995..1985000) /Source="Nicolas_upshift_promotors" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(1985125..1986603) /gene="spoIVA" /locus_tag="BSU_22800" /old_locus_tag="BSU22800" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11160095, 17114257, 17427285, 24810258, 26387458, 28408070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160095, 17114257, 17427285, 24810258, 26387458, 28408070; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="morphogenetic stage IV sporulation protein" /protein_id="NP_390161.1" /db_xref="EnsemblGenomes-Gn:BSU22800" /db_xref="EnsemblGenomes-Tr:CAB14196" /db_xref="GOA:P35149" /db_xref="InterPro:IPR014201" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10275" /db_xref="UniProtKB/Swiss-Prot:P35149" /translation="MEKVDIFKDIAERTGGDIYLGVVGAVRTGKSTFIKKFMELVVLP NISNEADRARAQDELPQSAAGKTIMTTEPKFVPNQAMSVHVSDGLDVNIRLVDCVGYT VPGAKGYEDENGPRMINTPWYEEPIPFHEAAEIGTRKVIQEHSTIGVVITTDGTIGDI ARSDYIEAEERVIEELKEVGKPFIMVINSVRPYHPETEAMRQDLSEKYDIPVLAMSVE SMRESDVLSVLREALYEFPVLEVNVNLPSWVMVLKENHWLRESYQESVKETVKDIKRL RDVDRVVGQFSEFEFIESAGLAGIELGQGVAEIDLYAPDHLYDQILKEVVGVEIRGRD HLLELMQDFAHAKTEYDQVSDALKMVKQTGYGIAAPALADMSLDEPEIIRQGSRFGVR LKAVAPSIHMIKVDVESEFAPIIGTEKQSEELVRYLMQDFEDDPLSIWNSDIFGRSLS SIVREGIQAKLSLMPENARYKLKETLERIINEGSGGLIAIIL*" /label="spoIVA CDS" gene complement(1985125..1986603) /gene="spoIVA" /locus_tag="BSU_22800" /old_locus_tag="BSU22800" /label="spoIVA gene" downshifts complement(1985138) /Source="Nicolas_upshifts" /id="D1188" /incds=0 /nref=59 /ntot=76 /MaxReadThrough="3.43222" /MaxDrop="7.13908" /score="13.6316529" /energy="-9.2" /TU="U1781" /idTUdmin="U1782" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1986604..1986765) /Source="Nicolas_S_feature" /locus_tag="new_2387674_2387835_c" /HighExp="S3, S4, S5, S6, LoTm, S7, B36, BT, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S862" promotor_-10 complement(1986752..1986770) /Source="Nicolas_upshift_promotors" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="promotor_-10" upshifts complement(1986777) /Source="Nicolas_upshifts" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="upshifts" CDS complement(1986784..1987518) /gene="yphF" /locus_tag="BSU_22810" /old_locus_tag="BSU22810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein of unknown function" /protein_id="NP_390162.1" /db_xref="EnsemblGenomes-Gn:BSU22810" /db_xref="EnsemblGenomes-Tr:CAB14197" /db_xref="SubtiList:BG10274" /db_xref="UniProtKB/Swiss-Prot:P39911" /translation="MGKLKCAIIFAAVVFLSGCLYPNERKSSVHAIPYQDQLKQVQSA VDEFQKANGGLLPIQTKDMSTPLYQKYPIDFNRLAPRYIAEPPSTAFESGGDYQYVLV DVENDPTVKLIDLKMAEKIRDVKLRIQMYRQEHQYPPYKDVLSRDLFTLDEKKLGDGS SLTVTSPISGNSLPLMIDGDGEIYADYRTELASCLKKSKKTFKPGTEIQDMIWHETPF VPAFSVKYTVNDKQEPVFLENDMKKE*" /label="yphF CDS" gene complement(1986784..1987518) /gene="yphF" /locus_tag="BSU_22810" /old_locus_tag="BSU22810" /label="yphF gene" promotor_-35 complement(1986785..1986790) /Source="Nicolas_upshift_promotors" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="promotor_-35" downshifts complement(1986810) /Source="Nicolas_upshifts" /id="D1189" /incds=0 /nref=6 /ntot=78 /MaxReadThrough="6.50932" /MaxDrop="4.759" /score="15.8109079" /energy="-12.7" /TU="U1782" /idTUdmin="U1783" /TUdmin=1100 /isTUend="FALSE" /label="downshifts" CDS complement(1987540..1987743) /gene="yphE" /locus_tag="BSU_22820" /old_locus_tag="BSU22820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390163.1" /db_xref="EnsemblGenomes-Gn:BSU22820" /db_xref="EnsemblGenomes-Tr:CAB14198" /db_xref="GOA:P50744" /db_xref="InterPro:IPR020076" /db_xref="SubtiList:BG11444" /db_xref="UniProtKB/Swiss-Prot:P50744" /translation="MNLALMKMWFALGSMGLMFLAVASIYLSRFKCQNRFLKIAISSF AYMCMLISGIIVFVVVFSGPVNE*" /label="yphE CDS" gene complement(1987540..1987743) /gene="yphE" /locus_tag="BSU_22820" /old_locus_tag="BSU22820" /label="yphE gene" promotor_-10 complement(1987779..1987798) /Source="Nicolas_upshift_promotors" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1987800) /Source="Nicolas_upshifts" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1987812..1987819) /Source="Nicolas_upshift_promotors" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1987865..1988064) /Source="Nicolas_S_feature" /locus_tag="new_2388935_2389134_c" /HighExp="S7, S8, S6, C30, BT, G135, G180, Oxctl, Cold, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, Sig-" /TUshortPSig="1, 1, 0.481" /TUlongSig="NA" /TUlongPSig="NA" /label="S863" downshifts complement(1987908) /Source="Nicolas_upshifts" /id="D1190" /incds=0 /nref=264 /ntot=295 /MaxReadThrough="2.22999" /MaxDrop="8.05743" /score="26.216597" /energy="-14.1" /TU="NA" /idTUdmin="U1783" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1988039..1988058) /Source="Nicolas_upshift_promotors" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1988064) /Source="Nicolas_upshifts" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1988072..1988081) /Source="Nicolas_upshift_promotors" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1988081..1989118) /gene="gpsA" /locus_tag="BSU_22830" /old_locus_tag="BSU22830" /EC_number="1.1.1.94" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592341, 12682299, 15557260" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592341, 12682299, 15557260; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent glycerol-3-phosphate dehydrogenase" /protein_id="NP_390164.1" /db_xref="EnsemblGenomes-Gn:BSU22830" /db_xref="EnsemblGenomes-Tr:CAB14199" /db_xref="GOA:P46919" /db_xref="InterPro:IPR006109" /db_xref="InterPro:IPR006168" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR011128" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11366" /db_xref="UniProtKB/Swiss-Prot:P46919" /translation="MKKVTMLGAGSWGTALALVLTDNGNEVCVWAHRADLIHQINELH ENKDYLPNVKLSTSIKGTTDMKEAVSDADVIIVAVPTKAIREVLRQAVPFITKKAVFV HVSKGIEPDSLLRISEIMEIELPSDVRKDIVVLSGPSHAEEVGLRHPTTVTASSKSMR AAEEVQDLFINHNFRVYTNPDIIGVEIGGALKNIIALAAGITDGLGYGDNAKAALITR GLAEIARLGTKMGGNPLTFSGLTGVGDLIVTCTSVHSRNWRAGNLLGKGYKLEDVLEE MGMVVEGVRTTKAAYQLSKKYDVKMPITEALHQVLFNGQKVETAVESLMARGKTHEME DLVNTFENQVK*" /label="gpsA CDS" gene complement(1988081..1989118) /gene="gpsA" /locus_tag="BSU_22830" /old_locus_tag="BSU22830" /label="gpsA gene" CDS complement(1989136..1990446) /gene="der" /locus_tag="BSU_22840" /old_locus_tag="BSU22840" /EC_number="3.6.5.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16682769, 16894162, 16997968, 19246542, 23056455, 24822275, 27484475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16682769, 16894162, 16997968, 19246542, 23056455, 24822275, 27484475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase essential for ribosome 50S subunit assembly (maturation of the 50S subunit central protoberance)" /protein_id="NP_390165.1" /db_xref="EnsemblGenomes-Gn:BSU22840" /db_xref="EnsemblGenomes-Tr:CAB14200" /db_xref="GOA:P50743" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR016484" /db_xref="InterPro:IPR027368" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031166" /db_xref="InterPro:IPR032859" /db_xref="PDB:2HJG" /db_xref="PDB:4DCS" /db_xref="PDB:4DCT" /db_xref="PDB:4DCU" /db_xref="PDB:4DCV" /db_xref="PDB:4KYU" /db_xref="PDB:5X4B" /db_xref="SubtiList:BG11443" /db_xref="UniProtKB/Swiss-Prot:P50743" /translation="MGKPVVAIVGRPNVGKSTIFNRIAGERISIVEDTPGVTRDRIYS SAEWLNYDFNLIDTGGIDIGDEPFLAQIRQQAEIAMDEADVIIFMVNGREGVTAADEE VAKILYRTKKPVVLAVNKLDNTEMRANIYDFYSLGFGEPYPISGTHGLGLGDLLDAVA EHFKNIPETKYNEEVIQFCLIGRPNVGKSSLVNAMLGEERVIVSNVAGTTRDAVDTSF TYNQQEFVIVDTAGMRKKGKVYETTEKYSVLRALKAIDRSEVVAVVLDGEEGIIEQDK RIAGYAHEAGKAVVIVVNKWDAVDKDESTMKEFEENIRDHFQFLDYAPILFMSALTKK RIHTLMPAIIKASENHSLRVQTNVLNDVIMDAVAMNPTPTHNGSRLKIYYATQVSVKP PSFVVFVNDPELMHFSYERFLENRIRDAFGFEGTPIKIFARARK*" /label="der CDS" gene complement(1989136..1990446) /gene="der" /locus_tag="BSU_22840" /old_locus_tag="BSU22840" /label="der gene" S_feature complement(1990447..1990571) /Source="Nicolas_S_feature" /locus_tag="new_2391517_2391641_c" /HighExp="Cold, G180, G150, Oxctl, G135, C30, LBGexp, Paraq, dia0, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.481" /TUlongSig="NA" /TUlongPSig="NA" /label="S864" promotor_-10 complement(1990557..1990576) /Source="Nicolas_upshift_promotors" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1990571) /Source="Nicolas_upshifts" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1990591..1990594) /Source="Nicolas_upshift_promotors" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1990600..1990794) /gene="ypzH" /locus_tag="BSU_22849" /old_locus_tag="BSU22849" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097755.1" /db_xref="EnsemblGenomes-Gn:BSU22849" /db_xref="EnsemblGenomes-Tr:CAX52654" /db_xref="UniProtKB/Swiss-Prot:C0H445" /translation="MSESLTKVILSVITTNRNRVAGGAPVFFCNDQKEMELFAKNLEA ILDGIAHRIGDDVYLIVKHF*" /label="ypzH CDS" gene complement(1990600..1990794) /gene="ypzH" /locus_tag="BSU_22849" /old_locus_tag="BSU22849" /label="ypzH gene" CDS complement(1990791..1991684) /gene="yphB" /locus_tag="BSU_22850" /old_locus_tag="BSU22850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390166.1" /db_xref="EnsemblGenomes-Gn:BSU22850" /db_xref="EnsemblGenomes-Tr:CAB14201" /db_xref="GOA:P50742" /db_xref="InterPro:IPR025918" /db_xref="SubtiList:BG11442" /db_xref="UniProtKB/Swiss-Prot:P50742" /translation="MSDYIYPIIAGVIAGIATRLYMLKTDYRQYPTYVHGKVIHIALG LIAAGLGAIIMPALLQEEFTAITFLTLAATQFRDVRNMERNTLTQMDSYELVSRGSTY IEGIAIAFESRNYIVIFTALLTTSAYVFLSIWAAVIAAVVCFLLAMKFMSGSVLKDIV DIEYIKPRFDGPGLFVDNIYMMNIGLPEKQELILKHGMGFILTPKNFNSAATIANLGQ RQAILFDVSNVLGVYRDSGEPSLTPIAKRDLNDGRVAVFVLPQIHHPETAVQIISNVP TLENAIRMPTEFIKNQDKVIG*" /label="yphB CDS" gene complement(1990791..1991684) /gene="yphB" /locus_tag="BSU_22850" /old_locus_tag="BSU22850" /label="yphB gene" CDS complement(1991681..1992280) /gene="yphA" /locus_tag="BSU_22860" /old_locus_tag="BSU22860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390167.1" /db_xref="EnsemblGenomes-Gn:BSU22860" /db_xref="EnsemblGenomes-Tr:CAB14202" /db_xref="GOA:P50741" /db_xref="InterPro:IPR014617" /db_xref="SubtiList:BG11441" /db_xref="UniProtKB/Swiss-Prot:P50741" /translation="MEQFYYYWSMWFLWVLTTFIFEKTKRRIAVSVFILTNIILSIHD IALYFSLNAAYLMFFVCGCVYAGYLGMYRFRYIMVYLTLVAAYAFVYLFALYDPVWFI IKPEWAAVILIVLLTASVERNFEKQLVLFVLGMCQGELVYSFVIQKLAGAMAVGGFQW LNACSAGMILLFGISKYEHLASQIGQKSKRSNKGATKMS*" /label="yphA CDS" gene complement(1991681..1992280) /gene="yphA" /locus_tag="BSU_22860" /old_locus_tag="BSU22860" /label="yphA gene" promotor_-35 1992153..1992159 /Source="Nicolas_upshift_promotors" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1992168..1992351 /Source="Nicolas_S_feature" /locus_tag="new_2393238_2393421" /HighExp="S5, S8, S6, S7, BT, S4, ferm, nit, Pyr, G/S" /AntisenseName="yphA" /AntisenseCor="0.73324773408178501" /AntisenseRegPval="-45.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.6" /TUlongSig="NA" /TUlongPSig="NA" /label="S865" upshifts 1992170 /Source="Nicolas_upshifts" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1992173..1992184 /Source="Nicolas_upshift_promotors" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1992291..1992309) /Source="Nicolas_upshift_promotors" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1992310) /Source="Nicolas_upshifts" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1992325..1992330) /Source="Nicolas_upshift_promotors" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1992358..1992489 /gene="ypzI" /locus_tag="BSU_22869" /old_locus_tag="BSU22869" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein" /protein_id="YP_003097756.2" /db_xref="EnsemblGenomes-Gn:BSU22869" /db_xref="EnsemblGenomes-Tr:CAX52655" /db_xref="InterPro:IPR025414" /db_xref="UniProtKB/Swiss-Prot:C0H446" /translation="MGKDRQEKKLKASGRVESDRDQSIHYDGATSLEQNGRFKKRKS* " /label="ypzI CDS" gene 1992358..1992489 /gene="ypzI" /locus_tag="BSU_22869" /old_locus_tag="BSU22869" /label="ypzI gene" downshifts 1992477 /Source="Nicolas_upshifts" /id="D1191" /incds=0 /nref=37 /ntot=122 /MaxReadThrough="0.20384" /MaxDrop="6.94664" /score="3.33160455" /energy="-13.2" /TU="NA" /idTUdmin="U1785" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1992532..1993581) /gene="fni" /locus_tag="BSU_22870" /old_locus_tag="BSU22870" /EC_number="5.3.3.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12798687, 14745175, 15206931" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12798687, 14745175, 15206931; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isopentenyl diphosphate isomerase (typeII)" /protein_id="NP_390168.3" /db_xref="EnsemblGenomes-Gn:BSU22870" /db_xref="EnsemblGenomes-Tr:CAB14203" /db_xref="GOA:P50740" /db_xref="InterPro:IPR000262" /db_xref="InterPro:IPR011179" /db_xref="InterPro:IPR013785" /db_xref="PDB:1P0K" /db_xref="PDB:1P0N" /db_xref="SubtiList:BG11440" /db_xref="UniProtKB/Swiss-Prot:P50740" /translation="MTRAERKRQHINHALSIGQKRETGLDDITFVHVSLPDLALEQVD ISTKIGELSSSSPIFINAMTGGGGKLTYEINKSLARAASQAGIPLAVGSQMSALKDPS ERLSYEIVRKENPNGLIFANLGSEATAAQAKEAVEMIGANALQIHLNVIQEIVMPEGD RSFSGALKRIEQICSRVSVPVIVKEVGFGMSKASAGKLYEAGAAAVDIGGYGGTNFSK IENLRRQRQISFFNSWGISTAASLAEIRSEFPASTMIASGGLQDALDVAKAIALGASC TGMAGHFLKALTDSGEEGLLEEIQLILEELKLIMTVLGARTIADLQKAPLVIKGETHH WLTERGVNTSSYSVR*" /label="fni CDS" gene complement(1992532..1993581) /gene="fni" /locus_tag="BSU_22870" /old_locus_tag="BSU22870" /label="fni gene" downshifts complement(1992552) /Source="Nicolas_upshifts" /id="D1192" /incds=0 /nref=209 /ntot=250 /MaxReadThrough="1.39069" /MaxDrop="4.82362" /score="15.2467448" /energy="-13.2" /TU="NA" /idTUdmin="U1788" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1993456) /Source="Nicolas_upshifts" /id="D1193" /incds=1 /nref=45 /ntot=237 /MaxReadThrough="6.15611" /MaxDrop="4.91722" /score="13.2731686" /energy="-15.7" /TU="U1788,U1789,U1790" /idTUdmin="U1788" /TUdmin="-904" /isTUend="FALSE" /label="downshifts" CDS complement(1993594..1994742) /gene="rpfA" /locus_tag="BSU_22880" /old_locus_tag="BSU22880" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9179491, 9862121, 14586115; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA degradation presenting factor (ribosomal protein S1 homolog)" /protein_id="NP_390169.1" /db_xref="EnsemblGenomes-Gn:BSU22880" /db_xref="EnsemblGenomes-Tr:CAB14204" /db_xref="GOA:P38494" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG11005" /db_xref="UniProtKB/Swiss-Prot:P38494" /translation="MTEEMNQIDVQVPEVGDVVKGIVTKVEDKHVDVEIINVKQSGII PISELSSLHVEKASDVVKVDDELDLKVTKVEDDALILSKRAVDADRAWEDLEKKFETK EVFEAEVKDVVKGGLVVDIGVRGFIPASLVEAHFVEDFTDYKGKTLSLLVVELDRDKN RVILSHRAVVESEQANKKQELLQSLEVGSVLDGKVQRLTDFGAFVDIGGIDGLVHISQ LSHSHVEKPSDVVEEGQEVKVKVLSVDRDNERISLSIKDTLPGPWNQIGEKVKPGDVL EGTVQRLVSFGAFVEILPGVEGLVHISQISNKHIGTPHEVLEEGQTVKVKVLDVNENE ERISLSMRELEETPKADQEDYRQYQAKEETSTGFQLGDLIGDKLNKLK*" /label="rpfA CDS" gene complement(1993594..1994742) /gene="rpfA" /locus_tag="BSU_22880" /old_locus_tag="BSU22880" /label="rpfA gene" misc_feature 1993923..1993926 /Source="Nicolas_upshift_promotors" /id="U1787" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.677322677322677" /psig="0.023976023976024" /xcortree=89 /SigmaFactorBS="ttacaagacgctgtacagttccttcaagcacatCGCCaggct tcactttttcgccgatttggttccaaggtccaggcagtgtatctttgatcgataaaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1993950 /Source="Nicolas_upshifts" /id="U1787" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.677322677322677" /psig="0.023976023976024" /xcortree=89 /SigmaFactorBS="ttacaagacgctgtacagttccttcaagcacatCGCCaggct tcactttttcgccgatttggttccaaggtccaggcagtgtatctttgatcgataaaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1994016 /Source="Nicolas_upshifts" /id="D1194" /incds=1 /nref=1 /ntot=124 /MaxReadThrough="1.88188" /MaxDrop="2.8624" /score="-3.97389972" /energy="-11.8" /TU="NA" /idTUdmin="U1787" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1994720 /Source="Nicolas_upshifts" /id="D1195" /incds=0 /nref=3 /ntot=200 /MaxReadThrough="1.33117" /MaxDrop="3.08345" /score="-3.97389972" /energy="-11.8" /TU="NA" /idTUdmin="U1787" /TUdmin=704 /isTUend="FALSE" /label="downshifts" S_feature complement(1994743..1994882) /Source="Nicolas_S_feature" /locus_tag="new_2395813_2395952_c" /HighExp="C90, Salt, Etha, Lbtran, HiOs, M40t90, S1, LBGtran, LoTm, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigA" /TUshortPSig="0.999, 0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S866" promotor_-10 complement(1994881..1994900) /Source="Nicolas_upshift_promotors" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1994882) /Source="Nicolas_upshifts" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1994884..1994974) /Source="Nicolas_S_feature" /locus_tag="new_2395954_2396044_c" /HighExp="G135, G180, LBGexp, C30, Cold, Oxctl, dia0, G150, Paraq, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40511799999999998" /TUshortSig="SigEF, SigA" /TUshortPSig="0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S867" promotor_-35 complement(1994915..1994922) /Source="Nicolas_upshift_promotors" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1994975..1995649) /gene="cmk" /locus_tag="BSU_22890" /old_locus_tag="BSU22890" /EC_number="2.7.4.25" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8576266, 9179491, 9862121, 11827479, 12682299, 16880539" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8576266, 9179491, 9862121, 11827479, 12682299, 16880539; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytidylate kinase" /protein_id="NP_390170.1" /db_xref="EnsemblGenomes-Gn:BSU22890" /db_xref="EnsemblGenomes-Tr:CAB14205" /db_xref="GOA:P38493" /db_xref="InterPro:IPR003136" /db_xref="InterPro:IPR011994" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11004" /db_xref="UniProtKB/Swiss-Prot:P38493" /translation="MEKKLSIAIDGPAAAGKSTVAKIVAEKKSYIYIDTGAMYRAITY AALQENVDLTDEEKLAELLKRTDIELITTKDGQKVFVNGTDVTEAIRTDEISNQVSIA AKHRSVREEMVKRQQQLGEKGGVVMDGRDIGTHVLPNAEVKIFLLASVEERAKRRYEE NVKKGFDVNYETLIEEIARRDKLDSEREVSPLRKAEDALEIDTTSLSIQEVADKILEA VEQKSR*" /label="cmk CDS" gene complement(1994975..1995649) /gene="cmk" /locus_tag="BSU_22890" /old_locus_tag="BSU22890" /label="cmk gene" S_feature complement(1995650..1995727) /Source="Nicolas_S_feature" /locus_tag="new_2396720_2396797_c" /HighExp="S4, S5, S7, S8, S6, dia15, S3, Diami, dia5, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S868" CDS complement(1995728..1995904) /gene="ypfB" /locus_tag="BSU_22900" /old_locus_tag="BSU22900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390171.1" /db_xref="EnsemblGenomes-Gn:BSU22900" /db_xref="EnsemblGenomes-Tr:CAB14206" /db_xref="InterPro:IPR035281" /db_xref="SubtiList:BG11003" /db_xref="UniProtKB/Swiss-Prot:P38492" /translation="MKTFERLLIKLLFIQAIILLGVQFLFHYQHIEPYVSKVIQYEGV DKMEENNRIETFKH*" /label="ypfB CDS" gene complement(1995728..1995904) /gene="ypfB" /locus_tag="BSU_22900" /old_locus_tag="BSU22900" /label="ypfB gene" promotor_-10 complement(1995916..1995934) /Source="Nicolas_upshift_promotors" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1995933) /Source="Nicolas_upshifts" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1995949..1995955) /Source="Nicolas_upshift_promotors" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1995949..1996602) /gene="dgrA" /locus_tag="BSU_22910" /old_locus_tag="BSU22910" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16249258, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16249258, 23893111, 28536559; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="cyclic di-GMP receptor" /protein_id="NP_390172.1" /db_xref="EnsemblGenomes-Gn:BSU22910" /db_xref="EnsemblGenomes-Tr:CAB14207" /db_xref="GOA:P38491" /db_xref="InterPro:IPR009875" /db_xref="InterPro:IPR009926" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG11002" /db_xref="UniProtKB/Swiss-Prot:P38491" /translation="MIEIGENVLLEYIEENELKKAKSKAVSIENNELLIAYPVDVVTG RTVILHNDMEVTVEFVGKDEVPYRFISRIKGKVKDKLQMICLEMPPREKMKRIQRRQY VRTDAVLDVQIQPGNEEEIRTLSYNISAGGIAVVLADGLSFQSGESLRLIIRLPEEEH TRQIETEAVVRRIFNDPKSEKRKMTLEYSEIAAGDQQALLQYCIRRQLNKRRKARME* " /label="dgrA CDS" gene complement(1995949..1996602) /gene="dgrA" /locus_tag="BSU_22910" /old_locus_tag="BSU22910" /label="dgrA gene" promotor_-10 complement(1996632..1996651) /Source="Nicolas_upshift_promotors" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1996645) /Source="Nicolas_upshifts" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1996667..1996671) /Source="Nicolas_upshift_promotors" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1996695..1998047) /gene="sleC" /locus_tag="BSU_22920" /old_locus_tag="BSU22920" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10658652, 12177332, 22720735, 23543708, 24752279, 25022853, 25384476, 26187959" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658652, 12177332, 22720735, 23543708, 24752279, 25022853, 25384476, 26187959; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination membrane component" /protein_id="NP_390173.1" /db_xref="EnsemblGenomes-Gn:BSU22920" /db_xref="EnsemblGenomes-Tr:CAB14208" /db_xref="GOA:P38490" /db_xref="InterPro:IPR014239" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG11001" /db_xref="UniProtKB/Swiss-Prot:P38490" /translation="MIRGILIAVLGIAIVGTGYWGYKEHQEKDAVLLHAENNYQRAFH ELTYQVDQLHDKIGTTLAMNSQKSLSPALIDVWRITSEAHNSVSQLPLTLMPFNKTEE LLSKIGDFSYKTSVRDLDQKPLDKNEYTSLNKLYQQSEDIQNELRHVQHLVMSKNLRW MDVEMALASDEKQSDNTIINSFKTVEKNVGAFSTGTDLGPSFTSTKKEEKGFSHLKGK QISEQEAKQIAERFAPDDNYSIKVVKSGKKTNRDVYSISMKDPDHKAVIYMDITKKGG HPVYLIQNREVKDQKISLNDGSNRALAFLKKNGFETDDLEIDESAQYDKIGVFSYVPV ENKVRMYPEAIRMKVALDDGEVVGFSARDFLTSHRKRTIPKPAITEAEAKSKLNKNVQ VRETRLALITNELGQEVLCYEMLGTIENDTFRMYINAKDGSEEKVEKLKNAEPIYKDL *" /label="sleC CDS" gene complement(1996695..1998047) /gene="sleC" /locus_tag="BSU_22920" /old_locus_tag="BSU22920" /label="sleC gene" downshifts complement(1996710) /Source="Nicolas_upshifts" /id="D1196" /incds=0 /nref=21 /ntot=44 /MaxReadThrough="0.647060000000002" /MaxDrop="5.74199" /score="16.6521528" /energy="-10.1" /TU="NA" /idTUdmin="U1791" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1998082..1998999) /gene="sleB" /locus_tag="BSU_22930" /old_locus_tag="BSU22930" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10658652, 12177332, 16905870, 16907803, 25963559, 26187959, 28333204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658652, 12177332, 16905870, 16907803, 25963559, 26187959, 28333204; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination cortex-lytic enzyme" /protein_id="NP_390174.1" /db_xref="EnsemblGenomes-Gn:BSU22930" /db_xref="EnsemblGenomes-Tr:CAB14209" /db_xref="GOA:P50739" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR011105" /db_xref="InterPro:IPR014224" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG11439" /db_xref="UniProtKB/Swiss-Prot:P50739" /translation="MKSKGSIMACLILFSFTITTFINTETISAFSNQVIQRGATGDDV VELQARLQYNGYYNGKIDGVYGWGTYWAVRNFQDQFGLKEVDGLVGAKTKQTLICKSK YYREYVMEQLNKGNTFTHYGKIPLKYQTKPSKAATQKARQQAEARQKQPAEKTTQKPK ANANKQQNNTPAKARKQDAVAANMPGGFSNNDIRLLAQAVYGEARGEPYEGQVAIAAV ILNRLNSPLFPNSVAGVIFEPLAFTAVADGQIYMQPNETAREAVLDAINGWDPSEEAL YYFNPDTATSPWIWGRPQIKRIGKHIFCE*" /label="sleB CDS" gene complement(1998082..1998999) /gene="sleB" /locus_tag="BSU_22930" /old_locus_tag="BSU22930" /label="sleB gene" downshifts complement(1998470) /Source="Nicolas_upshifts" /id="D1197" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="6.35344" /MaxDrop="4.29326" /score="-3.16364421" /energy="-21.7" /TU="U1791,U1792" /idTUdmin="U1793" /TUdmin=682 /isTUend="FALSE" /label="downshifts" misc_feature complement(1998621..1998628) /Source="Nicolas_upshift_promotors" /id="U1791" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.245754245754246" /psig="0.374625374625375" /xcortree=1472 /SigmaFactorBS="gaatatgtcatggaacagctcaataaagggaatacattcacg cattacggaaaaatTCCGCTAAagtatcagacgaaaccatcaaaagcagcaacacaaa a" /listShort="ypeB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1998624) /Source="Nicolas_upshifts" /id="U1791" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.245754245754246" /psig="0.374625374625375" /xcortree=1472 /SigmaFactorBS="gaatatgtcatggaacagctcaataaagggaatacattcacg cattacggaaaaatTCCGCTAAagtatcagacgaaaccatcaaaagcagcaacacaaa a" /listShort="ypeB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1999037..1999048) /Source="Nicolas_upshift_promotors" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1999046) /Source="Nicolas_upshifts" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1999062..1999068) /Source="Nicolas_upshift_promotors" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1999138..1999794) /gene="prsW" /locus_tag="BSU_22940" /old_locus_tag="BSU22940" /EC_number="3.4.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15849754, 16816000, 16850406, 17020587, 19889088, 23155385, 28674070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16816000, 16850406, 17020587, 19889088, 23155385, 28674070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protease required for RsiW anti-sigma(W) degradation" /protein_id="NP_390175.1" /db_xref="EnsemblGenomes-Gn:BSU22940" /db_xref="EnsemblGenomes-Tr:CAB14210" /db_xref="GOA:P50738" /db_xref="InterPro:IPR023596" /db_xref="InterPro:IPR026898" /db_xref="SubtiList:BG11438" /db_xref="UniProtKB/Swiss-Prot:P50738" /translation="MFAIISAGIAPGIALLSYFYLKDQYDNEPVHMVLRSFFLGVVLV FPIMFIQYVLEKENVGGGSFFVSFLSSGFLEESLKWFILMISVYPHAHFDEHYDGIVY GASVSLGFATLENILYLIGHGVEHAFVRALLPVSCHALIGVIMGFYLGKARFSADKAR VKWLTLSLVVPSLLHGSYDFILTALSNWIYYMLPFMVFLWWFGLRKAKKARSVNMMQV *" /label="prsW CDS" gene complement(1999138..1999794) /gene="prsW" /locus_tag="BSU_22940" /old_locus_tag="BSU22940" /label="prsW gene" downshifts complement(1999152) /Source="Nicolas_upshifts" /id="D1198" /incds=0 /nref=239 /ntot=262 /MaxReadThrough="0.9181" /MaxDrop="6.61797" /score="-3.16364421" /energy="-21.7" /TU="NA" /idTUdmin="U1793" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1999819..1999838) /Source="Nicolas_upshift_promotors" /id="U1793" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=3121 /SigmaFactorBS="cattcgtatgctctttttgtttttttaagtgcagacagatgt aaaattttaaacaaCATGGTAGGATAGATGTAGGaatataaaggaaagaggttgcctg a" /listShort="prsW" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1999834) /Source="Nicolas_upshifts" /id="U1793" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=3121 /SigmaFactorBS="cattcgtatgctctttttgtttttttaagtgcagacagatgt aaaattttaaacaaCATGGTAGGATAGATGTAGGaatataaaggaaagaggttgcctg a" /listShort="prsW" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1999914..2000888) /gene="ypdA" /locus_tag="BSU_22950" /old_locus_tag="BSU22950" /EC_number="1.8.-.-" /function="16.6: Maintain" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20308541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bacillithiol biosynthesis thiol disulfide oxidoreductase" /protein_id="NP_390176.2" /db_xref="EnsemblGenomes-Gn:BSU22950" /db_xref="EnsemblGenomes-Tr:CAB14211" /db_xref="GOA:P50736" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR023856" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11436" /db_xref="UniProtKB/Swiss-Prot:P50736" /translation="MIQEKAIIIGGGPCGLSAAIHLKQIGIDALVIEKGNVVNSIYNY PTHQTFFSSSEKLEIGDVAFITENRKPVRIQALSYYREVVKRKNIRVNAFEMVRKVTK TQNNTFVIETSKETYTTPYCIIATGYYDHPNYMGVPGEDLPKVFHYFKEGHPYFDKDV VVIGGKNSSVDAALELVKSGARVTVLYRGNEYSPSIKPWILPEFEALVRNGTIRMEFG ACVEKITENEVVFRSGEKELITIKNDFVFAMTGYHPDHQFLEKIGVEIDKETGRPFFN EETMETNVEGVFIAGVIAAGNNANEIFIENGRFHGGHIAAEIAKRENH*" /label="ypdA CDS" gene complement(1999914..2000888) /gene="ypdA" /locus_tag="BSU_22950" /old_locus_tag="BSU22950" /label="ypdA gene" downshifts complement(1999922) /Source="Nicolas_upshifts" /id="D1199" /incds=0 /nref=239 /ntot=263 /MaxReadThrough="3.524" /MaxDrop="6.45954" /score="27.4058676" /energy="-12.2" /TU="U1796" /idTUdmin="U1796" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" promotor_-35 2000742..2000747 /Source="Nicolas_upshift_promotors" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2000763..2000781 /Source="Nicolas_upshift_promotors" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2000773..2000966 /Source="Nicolas_S_feature" /locus_tag="new_2401843_2402036" /HighExp="S8, S6, S7, S4, S5, C30, S3, BT, B36, C90" /AntisenseName="ypdA" /AntisenseCor="-0.487730736536516" /AntisenseRegPval="-16.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.958" /TUlongSig="NA" /TUlongPSig="NA" /label="S869" upshifts 2000773 /Source="Nicolas_upshifts" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="upshifts" downshifts 2000924 /Source="Nicolas_upshifts" /id="D1200" /incds=0 /nref=13 /ntot=27 /MaxReadThrough="1.93985" /MaxDrop="5.69954" /score="23.7306175" /energy="-9.3" /TU="NA" /idTUdmin="U1794" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2000997..2002280) /gene="gudB" /locus_tag="BSU_22960" /old_locus_tag="BSU22960" /EC_number="1.4.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9829940, 18326565, 22178969, 22720735, 25610436" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829940, 18326565, 22178969, 22720735, 25610436; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cryptic glutamate dehydrogenase (active after removal of a 9 bp insert)" /protein_id="NP_390177.2" /db_xref="EnsemblGenomes-Gn:BSU22960" /db_xref="EnsemblGenomes-Tr:CAB14212" /db_xref="GOA:P50735" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR014362" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR033922" /db_xref="InterPro:IPR036291" /db_xref="PDB:3K8Z" /db_xref="SubtiList:BG11435" /db_xref="UniProtKB/Swiss-Prot:P50735" /translation="MAADRNTGHTEEDKLDVLKSTQTVIHKALEKLGYPEEVYELLKE PMRLLTVKIPVRMDDGSVKIFTGYRAQHNDSVGPTKGGIRFHPNVTEKEVKAVKALSI WMSLKCGIIDLPYGGGKGGIVCDPRDMSFRELERLSRGYVRAISQIVGPTKDVPAPDV FTNSQIMAWMMDEYSRIDEFNSPGFITGKPLVLGGSHGRESATAKGVTICIKEAAKKR GIDIKGARVVVQGFGNAGSYLAKFMHDAGAKVVGISDAYGGLYDPEGLDIDYLLDRRD SFGTVTKLFNDTITNQELLELDCDILVPAAIENQITEENAHNIRAKIVVEAANGPTTL EGTKILSDRDILLVPDVLASAGGVTVSYFEWVQNNQGFYWSEEEVEEKLEKMMVKSFN NIYEMANNRRIDMRLAAYMVGVRKMAEASRFRGWI*" /label="gudB CDS" gene complement(2000997..2002280) /gene="gudB" /locus_tag="BSU_22960" /old_locus_tag="BSU22960" /label="gudB gene" downshifts complement(2001000) /Source="Nicolas_upshifts" /id="D1201" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="7.92262" /MaxDrop="4.04542" /score="18.1400723" /energy="-9.3" /TU="U1796" /idTUdmin="U1797" /TUdmin=1345 /isTUend="FALSE" /label="downshifts" promotor_-35 2001038..2001044 /Source="Nicolas_upshift_promotors" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2001056..2001060 /Source="Nicolas_upshift_promotors" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2001056 /Source="Nicolas_upshifts" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2002323..2002342) /Source="Nicolas_upshift_promotors" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2002344) /Source="Nicolas_upshifts" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2002357..2002364) /Source="Nicolas_upshift_promotors" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2002436..2003020) /gene="mecB" /locus_tag="BSU_22970" /old_locus_tag="BSU22970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11914365, 19801546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914365, 19801546; Product type f: factor" /codon_start=1 /transl_table=11 /product="adaptor to ClpC; regulator of competence and sporulation" /protein_id="NP_390178.1" /db_xref="EnsemblGenomes-Gn:BSU22970" /db_xref="EnsemblGenomes-Tr:CAB14213" /db_xref="GOA:P50734" /db_xref="InterPro:IPR008681" /db_xref="PDB:3JTN" /db_xref="PDB:3JTO" /db_xref="SubtiList:BG11434" /db_xref="UniProtKB/Swiss-Prot:P50734" /translation="MRLERLNYNKIKIFLTLDDLTDRGLTKEDLWKDSFKVHQLFKDM MNEANTELGFEANGPIAVEVYSLQAQGMVVIVTKNQDADSEDDEYDDDYIEMQVKLDE SADIIYQFHSFEDIIQLSESLQRIGITGGTVYHYDGQYFLSLEDLGSHTAEGVVAVLA EYGNPTTLTIYRLQEYGKLIMDGNAVETIQTHFS*" /label="mecB CDS" gene complement(2002436..2003020) /gene="mecB" /locus_tag="BSU_22970" /old_locus_tag="BSU22970" /label="mecB gene" downshifts complement(2002438) /Source="Nicolas_upshifts" /id="D1202" /incds=0 /nref=258 /ntot=274 /MaxReadThrough="3.02006" /MaxDrop="7.92719" /score="23.8885529" /energy="-7.1" /TU="U1797" /idTUdmin="U1797" /TUdmin="-93" /isTUend="FALSE" /label="downshifts" S_feature complement(2003021..2003102) /Source="Nicolas_S_feature" /locus_tag="new_2404091_2404172_c" /HighExp="dia5, Diami, Etha, dia15, C90, Salt, LPhT, Heat, MG-0.2, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S870" promotor_-10 complement(2003095..2003114) /Source="Nicolas_upshift_promotors" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="promotor_-10" upshifts complement(2003102) /Source="Nicolas_upshifts" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="upshifts" promotor_-35 complement(2003128..2003135) /Source="Nicolas_upshift_promotors" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="promotor_-35" CDS complement(2003179..2003958) /gene="ypbG" /locus_tag="BSU_22980" /old_locus_tag="BSU22980" /EC_number="3.1.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15838020, 17434969; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoesterase" /protein_id="NP_390179.1" /db_xref="EnsemblGenomes-Gn:BSU22980" /db_xref="EnsemblGenomes-Tr:CAB14214" /db_xref="GOA:P50733" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11433" /db_xref="UniProtKB/Swiss-Prot:P50733" /translation="MKLSVKIAGVLTVAAAAMTAKMYATAKGNHLKTHTFPLSKMKGK PPLTIFFISDIHKRLIDQDLLEKARSHAPHLVIIGGDLAEGGVPSARIEENIKRLVHF GVPIVFVWGNNDYEVRQHKLYSIFKAHGVITLRNESVPFSYNGHTIAIAGVDDIRMEM DHYEEAIKELDESQLNILVCHNPEIHEQINEDDGIDVILSGHTHGGQIRFGKFGPYEL GKTGIVKNAAYLISNGYGTTKVPLRLGAEPETHIVTLCGPE*" /label="ypbG CDS" gene complement(2003179..2003958) /gene="ypbG" /locus_tag="BSU_22980" /old_locus_tag="BSU22980" /label="ypbG gene" promotor_-10 complement(2003984..2003999) /Source="Nicolas_upshift_promotors" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="promotor_-10" upshifts complement(2003995) /Source="Nicolas_upshifts" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="upshifts" promotor_-35 complement(2004011..2004020) /Source="Nicolas_upshift_promotors" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="promotor_-35" CDS complement(2004044..2004487) /gene="ypbF" /locus_tag="BSU_22990" /old_locus_tag="BSU22990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390180.1" /db_xref="EnsemblGenomes-Gn:BSU22990" /db_xref="EnsemblGenomes-Tr:CAB14215" /db_xref="GOA:P50732" /db_xref="InterPro:IPR020210" /db_xref="SubtiList:BG11432" /db_xref="UniProtKB/Swiss-Prot:P50732" /translation="MESLWNQLDQFTDAPTKQMLQALVKRKQKFENYAAQCRRWRWAS LICLGLLCVMIMIKSPEPQLILQEILSHTFYLFWMLATAFAYCTSYYFKKKEEKSETD FHKLRCEIIQKSTDLWPQPDKWKARESVFHMMKHKYDINLYFESK*" /label="ypbF CDS" gene complement(2004044..2004487) /gene="ypbF" /locus_tag="BSU_22990" /old_locus_tag="BSU22990" /label="ypbF gene" downshifts complement(2004061) /Source="Nicolas_upshifts" /id="D1203" /incds=0 /nref=4 /ntot=112 /MaxReadThrough="4.67294" /MaxDrop="3.33254" /score="6.86206051" /energy="-7.5" /TU="U1801" /idTUdmin="U1799" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(2004550..2005272) /gene="ypbE" /locus_tag="BSU_23000" /old_locus_tag="BSU23000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16855244, 22950025; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme possibly involved in cell wall turnover" /protein_id="NP_390181.1" /db_xref="EnsemblGenomes-Gn:BSU23000" /db_xref="EnsemblGenomes-Tr:CAB14216" /db_xref="GOA:P50731" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11431" /db_xref="UniProtKB/Swiss-Prot:P50731" /translation="MTNMSRVERRKAQNLYEDQNAALADDYVDDGESLPTRQSVKNQR EQKKKQGKTKTPLFTVLAVIFVFVPVIVLVTLFYLKSHPDNHDDYEDVFIDSSQSKYE VVPKSEDKNDTADTKETALQKESKKEPEDSKPKEQTAADKKQTAVAEKEDSPNKEEAT AAAASSSQSTVQQQEQPAEPVQNVPNRVVKHTVQKKETLYRISMKYYKSRTGEEKIRA YNHLNGNDVYTGQVLDIPLMDE*" /label="ypbE CDS" gene complement(2004550..2005272) /gene="ypbE" /locus_tag="BSU_23000" /old_locus_tag="BSU23000" /label="ypbE gene" downshifts complement(2004831) /Source="Nicolas_upshifts" /id="D1204" /incds=1 /nref=4 /ntot=93 /MaxReadThrough="4.30678" /MaxDrop="3.33147" /score="6.86206051" /energy="-7.5" /TU="U1799,U1801" /idTUdmin="U1799" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" CDS complement(2005223..2005792) /gene="ypbD" /locus_tag="BSU_23010" /old_locus_tag="BSU23010" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390182.1" /db_xref="EnsemblGenomes-Gn:BSU23010" /db_xref="EnsemblGenomes-Tr:CAB14217" /db_xref="GOA:P50730" /db_xref="InterPro:IPR003675" /db_xref="SubtiList:BG11430" /db_xref="UniProtKB/Swiss-Prot:P50730" /translation="MTQLLIIFAAAAAGLFFFEDVRDVLKLWDIRDMRIIWYGVSIAV IVILADMAVMKWFPSHLYDDGGINKKIFSKRSIPHIIFLTLLIAFAEEMLFRGVLQTH IGLWTASLIFAALHFRYLSKWLLFIMVTAISFLLGLMYEWTGNLFVPMTAHFIIDAVF ACQIRFEHVRRDKHDEHVESREKKSPESL*" /label="ypbD CDS" gene complement(2005223..2005792) /gene="ypbD" /locus_tag="BSU_23010" /old_locus_tag="BSU23010" /label="ypbD gene" promotor_-10 complement(2005541..2005559) /Source="Nicolas_upshift_promotors" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2005557) /Source="Nicolas_upshifts" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2005574..2005580) /Source="Nicolas_upshift_promotors" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2005811..2006557 /Source="Nicolas_S_feature" /locus_tag="new_2406881_2407627" /HighExp="S6, S8, S7, C30, BT, S5, C90, Pyr, BC, Sw" /AntisenseName="recQ" /AntisenseCor="-0.47918253719211501" /AntisenseRegPval="-16.100000000000001" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S871" CDS complement(2005852..2007342) /gene="recS" /locus_tag="BSU_23020" /old_locus_tag="BSU23020" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16385024, 25246477, 26001966, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385024, 25246477, 26001966, 28527403; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA helicase" /protein_id="NP_390183.1" /db_xref="EnsemblGenomes-Gn:BSU23020" /db_xref="EnsemblGenomes-Tr:CAB14218" /db_xref="GOA:P50729" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR002464" /db_xref="InterPro:IPR004589" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11407" /db_xref="UniProtKB/Swiss-Prot:P50729" /translation="MTKLQQTLYQFFGFTSFKKGQQDIIESILSGKDTIAMLPTGGGK SLCYQLPGYMLDGMVLIVSPLLSLMEDQVQQLKARGEKRAAALNSMLNRQERQFVLEH IHRYKFLYLSPEALQSPYVLEKLKSVPISLFVIDEAHCISEWGHDFRPDYSKLGQLRK KLGHPPVLALTATATKETLQDVMNLLELQHAVRHLNSVNRPNIALRVENAADTAEKID RVIQLVENLQGPGIVYCPTRKWAKELAGEIKSKTSSRADFYHGGLESGDRILIQQQFI HNQLDVICCTNAFGMGVDKPDIRYVIHFHLPQTAEAFMQEIGRAGRDGKPSVSILLRA PGDFELQEQIIQMESVTAEEIADVIRVLEKTEERDERRLRDVLLQYGVGETQARMMIH LFMQGKTSVELMKKEISYRMELKLEKMHRVSFLLQRDGCLRQALLTYFDESYEPDDGN LPCCSHCGFDLSLYEQKGERSKMAPLDSWSSELHRIFSLQTVGELN*" /label="recS CDS" gene complement(2005852..2007342) /gene="recS" /locus_tag="BSU_23020" /old_locus_tag="BSU23020" /label="recS gene" CDS complement(2007335..2008393) /gene="gmmB" /locus_tag="BSU_23030" /old_locus_tag="BSU23030" /experiment="publication(s) with functional evidences, PMID:21170359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21170359; Product type f: factor" /codon_start=1 /transl_table=11 /product="subunit of the platform for genome maintenance machinery" /protein_id="NP_390184.1" /db_xref="EnsemblGenomes-Gn:BSU23030" /db_xref="EnsemblGenomes-Tr:CAB14219" /db_xref="InterPro:IPR008308" /db_xref="InterPro:IPR029491" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11429" /db_xref="UniProtKB/Swiss-Prot:P50728" /translation="MSLNYFDIMVLDCLCKINGERSGSAVFHLFKGKRSSQTIQDAGL FQTAKYFGMAAKCSRSDISASLDKLEKHSYLAPMSESDTYKVTASGAAVLRHALSERP WPVHCHGAHYQQAAGVLWKRLSLLVQVLSHKQQGSRQYIPVTKDHKTLHWVKKYLSRH TDHIEMAKSLFAMLEAHLKKIENKAAQIFVYSLTSHHRIGYTSRQLADTLKEDEWYVY IMFWASVHYFIHSLPECEDALLKDLLSDVHLDNALTESTRKTWQMVKQGFPIQRIAEI RKLKTATIEDHIVEISLHEPAFMINDYVSAEDQLQIAEFAKRMRTNKIKQIRDGLEQR FSYFQIRLALTKQVQQYD*" /label="gmmB CDS" gene complement(2007335..2008393) /gene="gmmB" /locus_tag="BSU_23030" /old_locus_tag="BSU23030" /label="gmmB gene" promotor_-35 2007683..2007692 /Source="Nicolas_upshift_promotors" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2007703..2008493 /Source="Nicolas_S_feature" /locus_tag="new_2408773_2409563" /HighExp="S8, S6, S7, S5, BT, B36, Pyr, G/S, B60, nit" /AntisenseName="ypbB" /AntisenseCor="-0.76734368116597995" /AntisenseRegPval="-52.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S872" upshifts 2007703 /Source="Nicolas_upshifts" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2007705..2007724 /Source="Nicolas_upshift_promotors" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2008434..2008453) /Source="Nicolas_upshift_promotors" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2008457) /Source="Nicolas_upshifts" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2008465..2008472) /Source="Nicolas_upshift_promotors" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2008471..2008477 /Source="Nicolas_upshift_promotors" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="promotor_-35" promotor_-10 2008491..2008510 /Source="Nicolas_upshift_promotors" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="promotor_-10" S_feature 2008495..2008564 /Source="Nicolas_S_feature" /locus_tag="new_2409565_2409634" /HighExp="S6, S8, S7, S5, BT, B36, C30, Pyr, B60, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK" /TUshortPSig="0.991, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S873" upshifts 2008495 /Source="Nicolas_upshifts" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="upshifts" promotor_-35 2008544..2008551 /Source="Nicolas_upshift_promotors" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2008566..2008658 /Source="Nicolas_S_feature" /locus_tag="new_2409636_2409728" /HighExp="LPhT, LBGstat, HPh, C90, LBGtran, C30, Lbtran, Cold, LPh, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 0.996" /TUlongSig="SigB" /TUlongPSig="0.991" /label="S874" promotor_-10 2008566..2008585 /Source="Nicolas_upshift_promotors" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2008566 /Source="Nicolas_upshifts" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="upshifts" CDS 2008659..2008907 /gene="fer" /locus_tag="BSU_23040" /old_locus_tag="BSU23040" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12538057, 21665975" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12538057, 21665975; Product type c: carrier" /codon_start=1 /transl_table=11 /product="ferredoxin" /protein_id="NP_390185.1" /db_xref="EnsemblGenomes-Gn:BSU23040" /db_xref="EnsemblGenomes-Tr:CAB14220" /db_xref="GOA:P50727" /db_xref="InterPro:IPR001080" /db_xref="InterPro:IPR017896" /db_xref="SubtiList:BG11388" /db_xref="UniProtKB/Swiss-Prot:P50727" /translation="MAKYTIVDKDTCIACGACGAAAPDIYDYDDEGIAFVTLDENKGV VEVPEVLEEDMIDAFEGCPTDSIKVADEPFEGDPLKFE*" /label="fer CDS" gene 2008659..2008907 /gene="fer" /locus_tag="BSU_23040" /old_locus_tag="BSU23040" /label="fer gene" downshifts 2008891 /Source="Nicolas_upshifts" /id="D1205" /incds=0 /nref=221 /ntot=291 /MaxReadThrough="3.16016" /MaxDrop="8.38074" /score="34.9672707" /energy="-9.9" /TU="U1803" /idTUdmin="U1800" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2008947..2009519) /gene="fmnP" /locus_tag="BSU_23050" /old_locus_tag="BSU23050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12456892, 15849754, 16850406, 17693491, 25438558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15849754, 16850406, 17693491, 25438558; Product type t : transporter" /codon_start=1 /transl_table=11 /product="FMN permease" /protein_id="NP_390186.1" /db_xref="EnsemblGenomes-Gn:BSU23050" /db_xref="EnsemblGenomes-Tr:CAB14237" /db_xref="GOA:P50726" /db_xref="InterPro:IPR024529" /db_xref="InterPro:IPR025720" /db_xref="SubtiList:BG11428" /db_xref="UniProtKB/Swiss-Prot:P50726" /translation="MKVKKLVVVSMLSSIAFVLMLLNFPFPGLPDYLKIDFSDVPAII AILIYGPLAGIAVEAIKNVLQYIIQGSMAGVPVGQVANFIAGTLFILPTAFLFKKLNS AKGLAVSLLLGTAAMTILMSILNYVLILPAYTWFLHSPALSDSALKTAVVAGILPFNM IKGIVITVVFSLIFIKLKPWIEQQRSAHIH*" /label="fmnP CDS" gene complement(2008947..2009519) /gene="fmnP" /locus_tag="BSU_23050" /old_locus_tag="BSU23050" /label="fmnP gene" downshifts complement(2008967) /Source="Nicolas_upshifts" /id="D1206" /incds=0 /nref=103 /ntot=231 /MaxReadThrough="2.60651" /MaxDrop="4.95518" /score="35.0684207" /energy="-9.9" /TU="NA" /idTUdmin="U1804" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA complement(2009511..2009818) /gene="fswB" /locus_tag="BSU_misc_RNA_78" /product="flavin mononucleotide riboswitch" /experiment="publication(s) with functional evidences, PMID:12456892, 15808508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15808508; Product type n: RNA" /label="fswB RNA" gene complement(2009511..2009818) /gene="fswB" /locus_tag="BSU_misc_RNA_78" /label="fswB gene" S_feature complement(2009520..2009624) /Source="Nicolas_S_feature" /locus_tag="new_2410590_2410694_c" /HighExp="S1, LPhT, M9-stat, B60, Heat, T0.30H, Gly, S5, BC, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S875" promotor_-10 complement(2009817..2009836) /Source="Nicolas_upshift_promotors" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2009833) /Source="Nicolas_upshifts" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2009850..2009856) /Source="Nicolas_upshift_promotors" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2009945..2009952 /Source="Nicolas_upshift_promotors" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2009963 /Source="Nicolas_upshifts" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2009967..2009986 /Source="Nicolas_upshift_promotors" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2010016..2011593 /gene="serA" /locus_tag="BSU_23070" /old_locus_tag="BSU23070" /EC_number="1.1.1.95" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:168067, 11390694, 17611193, 4337849, 21749987, 22938038, 28827360" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 168067, 11390694, 17611193, 4337849, 21749987, 22938038, 28827360; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-phosphoglycerate dehydrogenase" /protein_id="NP_390188.2" /db_xref="EnsemblGenomes-Gn:BSU23070" /db_xref="EnsemblGenomes-Tr:CAB14239" /db_xref="GOA:P35136" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR006236" /db_xref="InterPro:IPR029009" /db_xref="InterPro:IPR029752" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10509" /db_xref="UniProtKB/Swiss-Prot:P35136" /translation="MFRVLVSDKMSNDGLQPLIESDFIEIVQKNVADAEDELHTFDAL LVRSATKVTEDLFNKMTSLKIVGRAGVGVDNIDIDEATKHGVIVINAPNGNTISTAEH TFAMISSLMRHIPQANISVKSREWNRTAYVGSELYGKTLGIVGLGRIGSEIAQRARAF GMTVHVFDPFLTEERAKKIGVNSRTFEEVLESADIITVHTPLTKETKGLLNKETIAKT KKGVRLINCARGGIIDEAALLEALENGHVAGAALDVFEVEPPVDNKLVDHPLVIATPH LGASTKEAQLNVAAQVSEEVLQFAKGLPVMSAINLPAMTKDEFAKIKPYHQIAGKIGS LVSQCMKEPVQDVAIQYEGTIAKLETSFITKALLSGFLKPRVDSTVNEVNAGGVAKER GISFSEKISSSESGYDNCISVKVTGDRSTFTVTATYIPHFGERIVEINGFNIDFYPTG HLVYIQHQDTTGVIGRVGRILGDNDINIATMQVGRKEKGGEAIMMLSFDRHLEDKIVK ELTNVPDIVSVKLIDLP*" /label="serA CDS" gene 2010016..2011593 /gene="serA" /locus_tag="BSU_23070" /old_locus_tag="BSU23070" /label="serA gene" downshifts 2011575 /Source="Nicolas_upshifts" /id="D1207" /incds=0 /nref=246 /ntot=311 /MaxReadThrough="3.23011" /MaxDrop="8.29454" /score="32.0086708" /energy="-10.2" /TU="U1805" /idTUdmin="U1805" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" CDS complement(2011636..2012403) /gene="aroC" /locus_tag="BSU_23080" /old_locus_tag="BSU23080" /EC_number="4.2.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6442253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6442253; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate dehydratase" /protein_id="NP_390189.1" /db_xref="EnsemblGenomes-Gn:BSU23080" /db_xref="EnsemblGenomes-Tr:CAB14240" /db_xref="GOA:P35146" /db_xref="InterPro:IPR001381" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018508" /db_xref="SubtiList:BG10538" /db_xref="UniProtKB/Swiss-Prot:P35146" /translation="MNVLTIKGVSIGEGMPKIIIPLMGKTEKQILNEAEAVKLLNPDI VEWRVDVFEKANDREAVTKLISKLRKSLEDKLFLFTFRTHKEGGSMEMDESSYLALLE SAIQTKDIDLIDIELFSGDANVKALVSLAEENNVYVVMSNHDFEKTPVKDEIISRLRK MQDLGAHIPKMAVMPNDTGDLLTLLDATYTMKTIYADRPIITMSMAATGLISRLSGEV FGSACTFGAGEEASAPGQIPVSELRSVLDILHKNTRG*" /label="aroC CDS" gene complement(2011636..2012403) /gene="aroC" /locus_tag="BSU_23080" /old_locus_tag="BSU23080" /label="aroC gene" downshifts complement(2011651) /Source="Nicolas_upshifts" /id="D1208" /incds=0 /nref=152 /ntot=231 /MaxReadThrough="2.53428" /MaxDrop="5.12103" /score="24.3727755" /energy="-10.2" /TU="NA" /idTUdmin="U1806" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 2011905..2012517 /Source="Nicolas_S_feature" /locus_tag="new_2412975_2413587" /HighExp="B36, C30, LoTm, B60, C90, HiOs, BI, Sw, T1.0H, BT" /AntisenseName="aroC" /AntisenseCor="4.7354591214804703E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S876" promotor_-10 complement(2012430..2012449) /Source="Nicolas_upshift_promotors" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2012443) /Source="Nicolas_upshifts" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2012464..2012467) /Source="Nicolas_upshift_promotors" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2012477 /Source="Nicolas_upshifts" /id="D1209" /incds=0 /nref=10 /ntot=52 /MaxReadThrough="2.02363" /MaxDrop="5.64228" /score="10.7892325" /energy="-8.5" /TU="NA" /idTUdmin="U1805" /TUdmin=704 /isTUend="FALSE" /label="downshifts" CDS complement(2012515..2013621) /gene="rsiX" /locus_tag="BSU_23090" /old_locus_tag="BSU23090" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9139908, 9393439, 10712692, 14762009, 16306698" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9139908, 9393439, 10712692, 14762009, 16306698; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of sigma(X) activity" /protein_id="NP_390190.2" /db_xref="EnsemblGenomes-Gn:BSU23090" /db_xref="EnsemblGenomes-Tr:CAB14241" /db_xref="GOA:P35166" /db_xref="InterPro:IPR019606" /db_xref="SubtiList:BG10537" /db_xref="UniProtKB/Swiss-Prot:P35166" /translation="MMKSEWNEEQIKELLSQLPAVKDHRSPQDIYKRLTMAKRKNKPA VRWIGPACAAAIAVYIAFIISPHFFDQAQPQQKEASQENAVTKTETEDSPKAASSLDQ TSFVVPEKEQDNYITVAVADADTSAIIPVSIQKTNADQTIQDMLFESSELGILDHAIT IPTFIDEVEIKEKPKQKELSIRVHQPATAFSIKDDTLLKKLLKESLKWSPYEKVKFLS DQNETGVRIGSYGTFTEISIPKQSKRSYYLYQNKQGQDFLVPSNHSFDTVKEAIKEME SSSQEDTTPLIQAGAVQSVTKKQKHLYIRFSKESEVDDSIAGILMIEGLLLTAKEFGF TEVTFTETRTKKIGKYDISDAIPVPAAPNPISLN*" /label="rsiX CDS" gene complement(2012515..2013621) /gene="rsiX" /locus_tag="BSU_23090" /old_locus_tag="BSU23090" /label="rsiX gene" downshifts complement(2012532) /Source="Nicolas_upshifts" /id="D1210" /incds=0 /nref=155 /ntot=242 /MaxReadThrough="3.84557" /MaxDrop="5.30684" /score="7.9467954" /energy="-6.7" /TU="U1809" /idTUdmin="U1806" /TUdmin="-881" /isTUend="FALSE" /label="downshifts" CDS complement(2013557..2014141) /gene="sigX" /locus_tag="BSU_23100" /old_locus_tag="BSU23100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9636707, 11222589, 12399481, 14762009, 19767430, 27965645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9636707, 11222589, 12399481, 14762009, 19767430, 27965645; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor sigma(X)" /protein_id="NP_390191.2" /db_xref="EnsemblGenomes-Gn:BSU23100" /db_xref="EnsemblGenomes-Tr:CAB14242" /db_xref="GOA:P35165" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10536" /db_xref="UniProtKB/Swiss-Prot:P35165" /translation="MEETFQLLYDTYHQDLYQFLFYMVKDKNQTEDLLQEVYIRVLNS YHTFEGRSSEKTWLLSIARHVAIDWFRKQQTIRQRILGTFDWDTQDVRDQQLLPDELA VQHENVREIYAALDQCTIDQRAVIILRFIQGYSIQETAKALRFSESKVKTTQHRGLKV LRKHMELLREELMDDEVRMERRTDKGVVKSTSGS*" /label="sigX CDS" gene complement(2013557..2014141) /gene="sigX" /locus_tag="BSU_23100" /old_locus_tag="BSU23100" /label="sigX gene" promotor_-35 2013935..2013940 /Source="Nicolas_upshift_promotors" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2013951 /Source="Nicolas_upshifts" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2013955..2013959 /Source="Nicolas_upshift_promotors" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2014092..2014097 /Source="Nicolas_upshift_promotors" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2014109 /Source="Nicolas_upshifts" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2014113..2014131 /Source="Nicolas_upshift_promotors" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 2014149 /Source="Nicolas_upshifts" /id="D1211" /incds=0 /nref=8 /ntot=81 /MaxReadThrough="5.89234" /MaxDrop="4.38483" /score="6.57298987" /energy="-13.5" /TU="U1808" /idTUdmin="U1807" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2014190..2014209) /Source="Nicolas_upshift_promotors" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2014194..2014301 /Source="Nicolas_S_feature" /locus_tag="new_2415264_2415371" /HighExp="S4, S8, S6, S7, C30, S3, LoTm, B60, BT, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S877" upshifts complement(2014198) /Source="Nicolas_upshifts" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2014222..2014229) /Source="Nicolas_upshift_promotors" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2014257 /Source="Nicolas_upshifts" /id="D1212" /incds=0 /nref=12 /ntot=64 /MaxReadThrough="2.08559" /MaxDrop="4.36303" /score="6.57298987" /energy="-13.5" /TU="NA" /idTUdmin="U1808" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(2014286..2014344) /Source="Nicolas_S_feature" /locus_tag="new_2415356_2415414_c" /HighExp="Lbstat, BI, nit, S0, M40t90, Lbtran, M0t90, G135, Sw, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S878" downshifts complement(2014317) /Source="Nicolas_upshifts" /id="D1213" /incds=0 /nref=156 /ntot=252 /MaxReadThrough="2.62215" /MaxDrop="6.99198" /score="33.3049318" /energy="-13.5" /TU="NA" /idTUdmin="U1810" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(2014345..2016114) /gene="resE" /locus_tag="BSU_23110" /old_locus_tag="BSU23110" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11222591, 14996800, 16825793, 16885456, 17189364, 17322317, 17628154" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11222591, 14996800, 16825793, 16885456, 17189364, 17322317, 17628154; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase (ResD / ResE)" /protein_id="NP_390192.1" /db_xref="EnsemblGenomes-Gn:BSU23110" /db_xref="EnsemblGenomes-Tr:CAB14243" /db_xref="GOA:P35164" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:4ZR7" /db_xref="SubtiList:BG10535" /db_xref="UniProtKB/Swiss-Prot:P35164" /translation="MKFWKSVVGKLWFTILSLVLIVLFILTVLLLEFIENYHVEEAEN DLTQLANKVAVILENHEDQALARSITWELADNLTSIAIIQDEKNHWYSPNDKNRLSSI TVEQIQHDKDLNKALKDHKKVSKRTGLSDTDTDNERLIVGVPYEKDGKKGMVFLSQSL LAVKDTTKHTTRYIFLAAGIAIVLTTFFAFFLSSRVTYPLRKMREGAQDLAKGKFDTK IPILTQDEIGELATAFNQMGRQLNFHINALNQEKEQLSNILSSMADGVITINIDGTIL VTNPPAERFLQAWYYEQNMNIKEGDNLPPEAKELFQNAVSTEKEQMIEMTLQGRSWVL LMSPLYAESHVRGAVAVLRDMTEERRLDKLREDFIANVSHELRTPISMLQGYSEAIVD DIASSEEDRKEIAQIIYDESLRMGRLVNDLLDLARMESGHTGLHYEKINVNEFLEKII RKFSGVAKEKNIALDHDISLTEEEFMFDEDKMEQVFTNLIDNALRHTSAGGSVSISVH SVKDGLKIDIKDSGSGIPEEDLPFIFERFYKADKARTRGRAGTGLGLAIVKNIVEAHN GSITVHSRIDKGTTFSFYIPTKR*" /label="resE CDS" gene complement(2014345..2016114) /gene="resE" /locus_tag="BSU_23110" /old_locus_tag="BSU23110" /label="resE gene" downshifts complement(2014401) /Source="Nicolas_upshifts" /id="D1214" /incds=0 /nref=5 /ntot=13 /MaxReadThrough="7.56028" /MaxDrop="3.58685" /score="33.3049318" /energy="-13.5" /TU="U1810,U1811,U1812" /idTUdmin="U1810" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" CDS complement(2016111..2016833) /gene="resD" /locus_tag="BSU_23120" /old_locus_tag="BSU23120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 15375128, 16825793, 16885456, 17322317, 17628154" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 15375128, 16825793, 16885456, 17322317, 17628154; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator (ResD / ResE)" /protein_id="NP_390193.2" /db_xref="EnsemblGenomes-Gn:BSU23120" /db_xref="EnsemblGenomes-Tr:CAB14244" /db_xref="GOA:P35163" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10534" /db_xref="UniProtKB/Swiss-Prot:P35163" /translation="MDQTNETKILVVDDEARIRRLLRMYLERENYAIDEAENGDEAIA KGLEANYDLILLDLMMPGTDGIEVCRQIREKKATPIIMLTAKGEEANRVQGFEAGTDD YIVKPFSPREVVLRVKALLRRASQTSYFNANTPTKNVLVFSHLSIDHDAHRVTADGTE VSLTPKEYELLYFLAKTPDKVYDREKLLKEVWQYEFFGDLRTVDTHVKRLREKLNKVS PEAAKKIVTVWGVGYKFEVGAE*" /label="resD CDS" gene complement(2016111..2016833) /gene="resD" /locus_tag="BSU_23120" /old_locus_tag="BSU23120" /label="resD gene" S_feature complement(2016834..2016913) /Source="Nicolas_S_feature" /locus_tag="new_2417904_2417983_c" /HighExp="Lbstat, M0t90, ferm, M40t90, S2, S0, nit, M40t45, BI, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.998, 0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S879" CDS complement(2016914..2018089) /gene="resC" /locus_tag="BSU_23130" /old_locus_tag="BSU23130" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10844653, 12682299, 15849754, 16850406, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10844653, 12682299, 15849754, 16850406, 19682263; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for cytochrome c synthesis" /protein_id="NP_390194.2" /db_xref="EnsemblGenomes-Gn:BSU23130" /db_xref="EnsemblGenomes-Tr:CAB14245" /db_xref="GOA:P35162" /db_xref="InterPro:IPR002541" /db_xref="InterPro:IPR017562" /db_xref="SubtiList:BG10533" /db_xref="UniProtKB/Swiss-Prot:P35162" /translation="MAELSGNFLYAAFLVYLIAVPIFGGAIRGNKDKKGRPNRWANIG ITLSIVGFFCHLGYFITRWAASGHAPVSNMFEFTTAFGMMLVLAFIILYFLYRLPSLG LFTLSIALLLIAYASMFPTDISPLIPSLQSNWLYIHVTTAALGQAILAISFVAGVIFL LKHVDQTKPSKKTFWLEAIMFILVTTVAFIAITSAFRLAGYEAEFNWVDKSKEKSVMV YEMPALVGPHQGELLTEGRMEPLVDLPALFSGRKVNTVIWSFGAGLVLYGALRLIIRK RISALLHPLVKNVNLDLVDEVGYRAVSIGFPIFTLGALIFAMIWAQLAWTRFWGWDPK EVWALITFLFYAAYLHLRLSRGWHGEKSAWLAVIGFAIIMFNLIFVNLVLAGLHSYA* " /label="resC CDS" gene complement(2016914..2018089) /gene="resC" /locus_tag="BSU_23130" /old_locus_tag="BSU23130" /label="resC gene" CDS complement(2018109..2019737) /gene="resB" /locus_tag="BSU_23140" /old_locus_tag="BSU23140" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9395519, 10844653, 12682299, 16825793, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9395519, 10844653, 12682299, 16825793, 19682263; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for cytochrome c synthesis" /protein_id="NP_390195.1" /db_xref="EnsemblGenomes-Gn:BSU23140" /db_xref="EnsemblGenomes-Tr:CAB14246" /db_xref="GOA:P35161" /db_xref="InterPro:IPR007816" /db_xref="SubtiList:BG10532" /db_xref="UniProtKB/Swiss-Prot:P35161" /translation="MKQVKCECGHINPVGTVLCESCGRALQETQPPLADMRYDGSARR SQTYNKTIIDKIWNFFSSVKVGIWLIVITLAASAFGTIFPQEAYLPPGAQADTYYKEQ YGTFGQLYYLLGFHHLYGSWWYLLLIASIGISLVICSLDRVIPLYRALKNQGVRRSPA FLRRQRLFSETVTVLNGESKEKIVTLLKKKHYRIREKEGSILAEKGRFSRWGPYVNHI GLIIFLIGAMLRFVPGMYVDETLWVREGETAAIPGTDGKYYLKNNQFSVETYNSKTEK KVFADAIDRVGDGRVAKNFQTDAVLYKREGKIVYGEKPKLEKVTEEDIRVNQPLRFDS FSVYQVDYKENQLDQMVFQLIDKKTKKSFGSLKINLLDPDSVYDLGNGYKVEIASYLP DFYFNQDGEPSTKTKIPNNPAFVFNIITPDKPKGEKSFVAIQETIEGSGNNKYKLKFD HVETKNITGLTVRKDLTLWVLAVGGAIFMIGVIQGMYWQHRRIWLHSQDGAVMVAGHT NKNWFGLKKDLAFILADSGLTEPVDQKELIKTQK*" /label="resB CDS" gene complement(2018109..2019737) /gene="resB" /locus_tag="BSU_23140" /old_locus_tag="BSU23140" /label="resB gene" CDS complement(2019734..2020273) /gene="resA" /locus_tag="BSU_23150" /old_locus_tag="BSU23150" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12637552, 12682299, 15667290, 16537372, 16825793, 16971393, 17189364, 18456809, 19682263, 22720735, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12637552, 12682299, 15667290, 16537372, 16825793, 16971393, 17189364, 18456809, 19682263, 22720735, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="extracytoplasmic thioredoxin involved in cytochrome c maturation (lipoprotein)" /protein_id="NP_390196.2" /db_xref="EnsemblGenomes-Gn:BSU23150" /db_xref="EnsemblGenomes-Tr:CAB14247" /db_xref="GOA:P35160" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR023555" /db_xref="InterPro:IPR036249" /db_xref="PDB:1ST9" /db_xref="PDB:1SU9" /db_xref="PDB:2F9S" /db_xref="PDB:2H19" /db_xref="PDB:2H1A" /db_xref="PDB:2H1B" /db_xref="PDB:2H1D" /db_xref="PDB:2H1G" /db_xref="PDB:3C71" /db_xref="PDB:3C73" /db_xref="SubtiList:BG10531" /db_xref="UniProtKB/Swiss-Prot:P35160" /translation="MKKKRRLFIRTGILLVLICALGYTIYNAVFAGKESISEGSDAPN FVLEDTNGKRIELSDLKGKGVFLNFWGTWCEPCKKEFPYMANQYKHFKSQGVEIVAVN VGESKIAVHNFMKSYGVNFPVVLDTDRQVLDAYDVSPLPTTFLINPEGKVVKVVTGTM TESMIHDYMNLIKPGETSG*" /label="resA CDS" gene complement(2019734..2020273) /gene="resA" /locus_tag="BSU_23150" /old_locus_tag="BSU23150" /label="resA gene" S_feature complement(2020274..2020367) /Source="Nicolas_S_feature" /locus_tag="new_2421344_2421437_c" /HighExp="LBGtran, LBGstat, G180, Oxctl, H2O2, G150, M0t90, G135, Paraq, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.998, 0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S880" CDS complement(2020368..2021102) /gene="rluB" /locus_tag="BSU_23160" /old_locus_tag="BSU23160" /EC_number="4.2.1.70" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9888802, 24214967" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9888802, 24214967; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA pseudouridine 2633 (=2605 standard) pseudouridine synthase" /protein_id="NP_390197.2" /db_xref="EnsemblGenomes-Gn:BSU23160" /db_xref="EnsemblGenomes-Tr:CAB14248" /db_xref="GOA:P35159" /db_xref="InterPro:IPR000748" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR018496" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10530" /db_xref="UniProtKB/Swiss-Prot:P35159" /translation="MERLQKVIAHAGVASRRKAEELIKEGKVKVNGKVVTELGVKVTG SDQIEVNGLKVEREEPVYFLLYKPRGVISAAQDDKGRKVVTDFFKNIPQRIYPIGRLD YDTSGLLLLTNDGEFANKLMHPKYEIDKTYVAKVKGIPPKELLRKLERGIRLEEGKTA PAKAKLLSLDKKKQTSIIQLTIHEGRNRQVRRMFEAIGHEVIKLKREEYAFLNLRGLH TGDARELTPHEVKRLRALADHGKNAF*" /label="rluB CDS" gene complement(2020368..2021102) /gene="rluB" /locus_tag="BSU_23160" /old_locus_tag="BSU23160" /label="rluB gene" promotor_-10 complement(2021111..2021130) /Source="Nicolas_upshift_promotors" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2021134) /Source="Nicolas_upshifts" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2021145..2021149) /Source="Nicolas_upshift_promotors" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2021194..2021730) /gene="spmB" /locus_tag="BSU_23170" /old_locus_tag="BSU23170" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 15849754, 16850406, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 15849754, 16850406, 19189487; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore maturation protein" /protein_id="NP_390198.2" /db_xref="EnsemblGenomes-Gn:BSU23170" /db_xref="EnsemblGenomes-Tr:CAB14249" /db_xref="GOA:P35158" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG10529" /db_xref="UniProtKB/Swiss-Prot:P35158" /translation="MEIINWLSLAMIPIIIAGILLYGTIKKVPTYESFVEGGKEGIEI AFSIIPYLVGMLVAITVFRSSGALDFIMDLLKPAFSAIGIPAEVVPLALIRPISGTAA LGMTTDLIAVYGPDSFIGRLASVMQGSTDTTLYVLTVYFGAVGIKKMGDALKVGLLAD LIGVVASIIIVTLLFGSA*" /label="spmB CDS" gene complement(2021194..2021730) /gene="spmB" /locus_tag="BSU_23170" /old_locus_tag="BSU23170" /label="spmB gene" promotor_-10 complement(2021199..2021218) /Source="Nicolas_upshift_promotors" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2021203) /Source="Nicolas_upshifts" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2021233..2021240) /Source="Nicolas_upshift_promotors" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2021735..2022325) /gene="spmA" /locus_tag="BSU_23180" /old_locus_tag="BSU23180" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 15849754, 16850406, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 15849754, 16850406, 19189487; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore maturation protein" /protein_id="NP_390199.1" /db_xref="EnsemblGenomes-Gn:BSU23180" /db_xref="EnsemblGenomes-Tr:CAB14250" /db_xref="GOA:P35157" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG10528" /db_xref="UniProtKB/Swiss-Prot:P35157" /translation="MVNIIWVSLTVIGLVFAMCNGTLQDVNEAVFKGAKEAITISFGL MSVLVFWLGLMKIAEQSGLLDIFSRMCRPFISKLFPDIPPDHPAMGYILSNLMANFFG LGNAATPLGIKAMEQMKKLNGNRSEASRSMITFLAVNTSCITLIPTTVIAVRMAYSSK TPTDIVGPSILATLISGIGAIIIDRYFYYRRKKKGR*" /label="spmA CDS" gene complement(2021735..2022325) /gene="spmA" /locus_tag="BSU_23180" /old_locus_tag="BSU23180" /label="spmA gene" CDS complement(2022313..2023461) /gene="dacB" /locus_tag="BSU_23190" /old_locus_tag="BSU23190" /EC_number="3.4.16.4" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 8892816, 9864321, 10498740, 18266856, 19542328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 8892816, 9864321, 10498740, 18266856, 19542328; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5*) (required for spore cortex)" /protein_id="NP_390200.1" /db_xref="EnsemblGenomes-Gn:BSU23190" /db_xref="EnsemblGenomes-Tr:CAB14251" /db_xref="GOA:P35150" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR018044" /db_xref="PDB:3MFD" /db_xref="SubtiList:BG10527" /db_xref="UniProtKB/Swiss-Prot:P35150" /translation="MRIFKKAVFVIMISFLIATVNVNTAHAAIDVSAKSAIIIDGASG RVLYAKDEHQKRRIASITKIMTAVLAIESGKMDQTVTVSANAVRTEGSAIYLTEGQKV KLKDLVYGLMLRSGNDAAVAIAEHVGGSLDGFVYMMNQKAEQLGMKNTRFQNPHGLDD HENHYSTAYDMAILTKYAMKLKDYQKISGTKIYKAETMESVWKNKNKLLTMLYPYSTG GKTGYTKLAKRTLVSTASKDGIDLIAVTINDPNDWDDHMKMFNYVFEHYQTYLIAKKG DIPKLKGTFYESKAFIKRDITYLLTEEEKENVKINTTLLKPKKAWEKDASKIPDIVGH MEIMFNDATIAKVPIYYENERHQKPKKQFFETFKSIFLNAAGGAKWSI*" /label="dacB CDS" gene complement(2022313..2023461) /gene="dacB" /locus_tag="BSU_23190" /old_locus_tag="BSU23190" /label="dacB gene" promotor_-10 complement(2023483..2023501) /Source="Nicolas_upshift_promotors" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2023490) /Source="Nicolas_upshifts" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2023516..2023521) /Source="Nicolas_upshift_promotors" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2023584..2024123) /gene="ypuI" /locus_tag="BSU_23200" /old_locus_tag="BSU23200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12065423" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390201.1" /db_xref="EnsemblGenomes-Gn:BSU23200" /db_xref="EnsemblGenomes-Tr:CAB14252" /db_xref="InterPro:IPR025013" /db_xref="SubtiList:BG10526" /db_xref="UniProtKB/Swiss-Prot:P35156" /translation="MKEAKCERQIHEGKIPNEMGHSIVRAQTQKTGEFLSMVVNTVND YLNQTTLESLQAELPIEKGYCCDVLSTLRRMAVFCEGGAEACRRLLMQEPFQEARAEK TLYNVYHQCIEEFFMPKKDTWCENSRASYTGVSAIEFYHAVPASLEQLLLPLSAAFLK MREELAHYEASGSSMAPIR*" /label="ypuI CDS" gene complement(2023584..2024123) /gene="ypuI" /locus_tag="BSU_23200" /old_locus_tag="BSU23200" /label="ypuI gene" downshifts complement(2023597) /Source="Nicolas_upshifts" /id="D1215" /incds=0 /nref=219 /ntot=260 /MaxReadThrough="1.63638" /MaxDrop="8.00748" /score="36.7302977" /energy="-12.2" /TU="NA" /idTUdmin="U1813" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2024132..2024149) /Source="Nicolas_upshift_promotors" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2024147) /Source="Nicolas_upshifts" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2024164..2024169) /Source="Nicolas_upshift_promotors" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2024178..2024771) /gene="spcB" /locus_tag="BSU_23210" /old_locus_tag="BSU23210" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 27435445, 28286005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 27435445, 28286005; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosome condensation and segregation factor" /protein_id="NP_390202.1" /db_xref="EnsemblGenomes-Gn:BSU23210" /db_xref="EnsemblGenomes-Tr:CAB14253" /db_xref="GOA:P35155" /db_xref="InterPro:IPR005234" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10525" /db_xref="UniProtKB/Swiss-Prot:P35155" /translation="MGLDIVNWKAIVEALLYAAGDEGLTKKQLLTVLEIEEPELNTIM ADVADEYRGDTRGIELIEYADTYMLSTKKDFAPYLKKLIEVPSKGLSQASLEVLAIVS YKQPITRAEIEEIRGVKSERILHSLVAKALLCEVGRADGPGRAILYGTTPTFLEQFGL KTLDELPPLPENAEEDVLQEEADLFFENFNQTFEDIK*" /label="spcB CDS" gene complement(2024178..2024771) /gene="spcB" /locus_tag="BSU_23210" /old_locus_tag="BSU23210" /label="spcB gene" CDS complement(2024761..2025516) /gene="scpA" /locus_tag="BSU_23220" /old_locus_tag="BSU23220" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 28286005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 28286005; Product type f: factor" /codon_start=1 /transl_table=11 /product="chromosome condensation and partitioning factor" /protein_id="NP_390203.1" /db_xref="EnsemblGenomes-Gn:BSU23220" /db_xref="EnsemblGenomes-Tr:CAB14254" /db_xref="GOA:P35154" /db_xref="InterPro:IPR003768" /db_xref="PDB:3ZGX" /db_xref="PDB:5H66" /db_xref="PDB:5H67" /db_xref="PDB:5XG3" /db_xref="SubtiList:BG10524" /db_xref="UniProtKB/Swiss-Prot:P35154" /translation="MEEYQVKIDTFEGPLDLLLHLINRLEIDIYDIPVAKITEQYLLY VHTMRVLELDIASEYLVMAATLLSIKSRMLLPKQEEELFEDELLEEEDPREELIEKLI EYRKYKDAAKDLKEREEERQKSFTKPPSDLSEYAKEVKQSEQKLSVTVYDMIGAFQKV LKRKKINRPMETTITRQDIPIEARMNEIVHSLKSRGTRINFMDLFPYEQKEHLVVTFL AVLELMKNQLVLIEQEHNFSDIYITGSESIHGA*" /label="scpA CDS" gene complement(2024761..2025516) /gene="scpA" /locus_tag="BSU_23220" /old_locus_tag="BSU23220" /label="scpA gene" promotor_-35 2025360..2025369 /Source="Nicolas_upshift_promotors" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2025382..2025401 /Source="Nicolas_upshift_promotors" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2025391 /Source="Nicolas_upshifts" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2025562..2025581) /Source="Nicolas_upshift_promotors" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2025577) /Source="Nicolas_upshifts" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2025595..2025602) /Source="Nicolas_upshift_promotors" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2025742..2025749 /Source="Nicolas_upshift_promotors" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2025760..2025779 /Source="Nicolas_upshift_promotors" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2025765 /Source="Nicolas_upshifts" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="upshifts" CDS 2025797..2026321 /gene="ypuF" /locus_tag="BSU_23230" /old_locus_tag="BSU23230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390204.1" /db_xref="EnsemblGenomes-Gn:BSU23230" /db_xref="EnsemblGenomes-Tr:CAB14255" /db_xref="InterPro:IPR005500" /db_xref="InterPro:IPR023203" /db_xref="SubtiList:BG10523" /db_xref="UniProtKB/Swiss-Prot:P17617" /translation="MYPKAYIDYLVEFHATRDYFECHEILEEYWKEDPPKKRKRYWVG FIQLAVALYHHRRQNTAGAKRLMANSIRILQAEHRAVEDLGLDHGRLLELMQSVYEQI ETVSAYKSIILPIKDEKLEEACRIECRKKKYTWGQPSALSNIFLIDKHRLRDRTDVIR EREKEIERRKKSRD*" /label="ypuF CDS" gene 2025797..2026321 /gene="ypuF" /locus_tag="BSU_23230" /old_locus_tag="BSU23230" /label="ypuF gene" CDS complement(2026335..2026709) /gene="ypzK" /locus_tag="BSU_23240" /old_locus_tag="BSU23240" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15466513, 25349719; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative riboflavin synthesis-related N-acetyltransferase" /protein_id="NP_390205.1" /db_xref="EnsemblGenomes-Gn:BSU23240" /db_xref="EnsemblGenomes-Tr:CAB14256" /db_xref="GOA:P17622" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10522" /db_xref="UniProtKB/Swiss-Prot:P17622" /translation="MLIRYKKSFEKIAMGLLSFMPNEKDLKQLQQTIKDYETDTDRQL FLWKEDEDIVGAIGVEKKDSEVEIRHISVNPSHRHQGIGKQMMDALKHLFKTQVLVPN ELTQSFFERCQGQQDQDISYNN*" /label="ypzK CDS" gene complement(2026335..2026709) /gene="ypzK" /locus_tag="BSU_23240" /old_locus_tag="BSU23240" /label="ypzK gene" downshifts complement(2026351) /Source="Nicolas_upshifts" /id="D1216" /incds=0 /nref=264 /ntot=275 /MaxReadThrough="1.34496" /MaxDrop="8.09525" /score="39.5464967" /energy="-14.3" /TU="NA" /idTUdmin="U1817" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2026771..2026790) /Source="Nicolas_upshift_promotors" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2026783) /Source="Nicolas_upshifts" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2026802..2026809) /Source="Nicolas_upshift_promotors" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2026822..2027286) /gene="ribH" /locus_tag="BSU_23250" /old_locus_tag="BSU23250" /EC_number="2.5.1.78" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3100522, 7473709, 10881048, 12456892, 24442413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3100522, 7473709, 10881048, 12456892, 24442413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6,7-dimethyl-8-ribityllumazine synthase, beta subunit" /protein_id="NP_390206.1" /db_xref="EnsemblGenomes-Gn:BSU23250" /db_xref="EnsemblGenomes-Tr:CAB14257" /db_xref="GOA:P11998" /db_xref="InterPro:IPR002180" /db_xref="InterPro:IPR034964" /db_xref="InterPro:IPR036467" /db_xref="PDB:1RVV" /db_xref="PDB:1ZIS" /db_xref="SubtiList:BG10521" /db_xref="UniProtKB/Swiss-Prot:P11998" /translation="MNIIQGNLVGTGLKIGIVVGRFNDFITSKLLSGAEDALLRHGVD TNDIDVAWVPGAFEIPFAAKKMAETKKYDAIITLGTVIRGATTHYDYVCNEAAKGIAQ AANTTGVPVIFGIVTTENIEQAIERAGTKAGNKGVDCAVSAIEMANLNRSFE*" /label="ribH CDS" gene complement(2026822..2027286) /gene="ribH" /locus_tag="BSU_23250" /old_locus_tag="BSU23250" /label="ribH gene" promotor_-35 2027157..2027161 /Source="Nicolas_upshift_promotors" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2027175..2027179 /Source="Nicolas_upshift_promotors" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2027178 /Source="Nicolas_upshifts" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2027319..2028515) /gene="ribBA" /locus_tag="BSU_23260" /old_locus_tag="BSU23260" /EC_number="3.5.4.25" /EC_number="4.1.99.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9297088, 9515916, 12456892, 19583770, 24442413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9297088, 9515916, 12456892, 19583770, 24442413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused 3,4-dihydroxy-2-butanone 4-phosphate synthase and GTP cyclohydrolase II" /protein_id="NP_390207.1" /db_xref="EnsemblGenomes-Gn:BSU23260" /db_xref="EnsemblGenomes-Tr:CAB14258" /db_xref="GOA:P17620" /db_xref="InterPro:IPR000422" /db_xref="InterPro:IPR000926" /db_xref="InterPro:IPR016299" /db_xref="InterPro:IPR017945" /db_xref="InterPro:IPR032677" /db_xref="InterPro:IPR036144" /db_xref="SubtiList:BG10520" /db_xref="UniProtKB/Swiss-Prot:P17620" /translation="MFHPIEEALDALKKGEVIIVVDDEDRENEGDFVALAEHATPEVI NFMATHGRGLICTPLSEEIADRLDLHPMVEHNTDSHHTAFTVSIDHRETKTGISAQER SFTVQALLDSKSVPSDFQRPGHIFPLIAKKGGVLKRAGHTEAAVDLAEACGSPGAGVI CEIMNEDGTMARVPELIEIAKKHQLKMITIKDLIQYRYNLTTLVEREVDITLPTDFGT FKVYGYTNEVDGKEHVAFVMGDVPFGEEPVLVRVHSECLTGDVFGSHRCDCGPQLHAA LNQIAAEGRGVLLYLRQEGRGIGLINKLKAYKLQEQGYDTVEANEALGFLPDLRNYGI GAQILRDLGVRNMKLLTNNPRKIAGLEGYGLSISERVPLQMEAKEHNKKYLQTKMNKL GHLLHF*" /label="ribBA CDS" gene complement(2027319..2028515) /gene="ribBA" /locus_tag="BSU_23260" /old_locus_tag="BSU23260" /label="ribBA gene" CDS complement(2028530..2029177) /gene="ribE" /locus_tag="BSU_23270" /old_locus_tag="BSU23270" /EC_number="2.5.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2106516, 12456892" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2106516, 12456892; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="riboflavin synthase (alpha subunit)" /protein_id="NP_390208.1" /db_xref="EnsemblGenomes-Gn:BSU23270" /db_xref="EnsemblGenomes-Tr:CAB14259" /db_xref="GOA:P16440" /db_xref="InterPro:IPR001783" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR023366" /db_xref="InterPro:IPR026017" /db_xref="SubtiList:BG10519" /db_xref="UniProtKB/Swiss-Prot:P16440" /translation="MFTGIIEETGTIESMKKAGHAMALTIKCSKILEDVHLGDSIAVN GICLTVTDFTKNQFTVDVMPETVKATSLNDLTKGSKVNLERAMAANGRFGGHFVSGHV DGTAEITRIEEKSNAVYYDLKMDPSLTKTLVLKGSITVDGVSLTIFGLTEDTVTISLI PHTISETIFSEKTIGSKVNIECDMIGKYMYRFLHKANENKTQQTITKAFLSENGF*" /label="ribE CDS" gene complement(2028530..2029177) /gene="ribE" /locus_tag="BSU_23270" /old_locus_tag="BSU23270" /label="ribE gene" CDS complement(2029188..2030273) /gene="ribD" /locus_tag="BSU_23280" /old_locus_tag="BSU23280" /EC_number="1.1.1.193" /EC_number="3.5.4.26" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9068650, 12456892, 17765262, 18986985, 23385458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9068650, 12456892, 17765262, 18986985, 23385458; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused diaminohydroxyphosphoribosylaminopyrimidine deaminase; 5-amino-6-(5-phosphoribosylamino) uracil reductase" /protein_id="NP_390209.1" /db_xref="EnsemblGenomes-Gn:BSU23280" /db_xref="EnsemblGenomes-Tr:CAB14260" /db_xref="GOA:P17618" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR002734" /db_xref="InterPro:IPR004794" /db_xref="InterPro:IPR011549" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR024072" /db_xref="PDB:2B3Z" /db_xref="PDB:2D5N" /db_xref="PDB:3EX8" /db_xref="PDB:4G3M" /db_xref="SubtiList:BG10518" /db_xref="UniProtKB/Swiss-Prot:P17618" /translation="MEEYYMKLALDLAKQGEGQTESNPLVGAVVVKDGQIVGMGAHLK YGEAHAEVHAIHMAGAHAEGADIYVTLEPCSHYGKTPPCAELIINSGIKRVFVAMRDP NPLVAGRGISMMKEAGIEVREGILADQAERLNEKFLHFMRTGLPYVTLKAAASLDGKI ATSTGDSKWITSEAARQDAQQYRKTHQSILVGVGTVKADNPSLTCRLPNVTKQPVRVI LDTVLSIPEDAKVICDQIAPTWIFTTARADEEKKKRLSAFGVNIFTLETERIQIPDVL KILAEEGIMSVYVEGGSAVHGSFVKEGCFQEIIFYFAPKLIGGTHAPSLISGEGFQSM KDVPLLQFTDITQIGRDIKLTAKPTKE*" /label="ribD CDS" gene complement(2029188..2030273) /gene="ribD" /locus_tag="BSU_23280" /old_locus_tag="BSU23280" /label="ribD gene" S_feature complement(2030274..2030402) /Source="Nicolas_S_feature" /locus_tag="new_2431344_2431472_c" /HighExp="T0.30H, B60, T1.30H, T2.0H, MG-0.2, T1.0H, S1, T0.0H, LPhT, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S881" misc_RNA complement(2030403..2030547) /gene="fswA" /locus_tag="BSU_misc_RNA_36" /product="flavin riboswitch" /experiment="publication(s) with functional evidences, PMID:12456892, 15808508, 17693491, 17997835" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15808508, 17693491, 17997835; Product type n: RNA" /label="fswA RNA" gene complement(2030403..2030547) /gene="fswA" /locus_tag="BSU_misc_RNA_36" /label="fswA gene" promotor_-10 complement(2030564..2030583) /Source="Nicolas_upshift_promotors" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2030574) /Source="Nicolas_upshifts" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2030598..2030605) /Source="Nicolas_upshift_promotors" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2030667..2031011) /gene="ypuD" /locus_tag="BSU_23300" /old_locus_tag="BSU23300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390211.1" /db_xref="EnsemblGenomes-Gn:BSU23300" /db_xref="EnsemblGenomes-Tr:CAB14262" /db_xref="SubtiList:BG10516" /db_xref="UniProtKB/Swiss-Prot:P17616" /translation="MGRIKTKITILLVLLLLLAGGYMYINDIELKDVPTAIGQTLSSE EEEYTIQEYKVTKIDGSEYHGVAENGTKIIFNGKKLNQDLSDIKEGDKIKAYFSKSKR IDGLIKVAKVND*" /label="ypuD CDS" gene complement(2030667..2031011) /gene="ypuD" /locus_tag="BSU_23300" /old_locus_tag="BSU23300" /label="ypuD gene" downshifts complement(2030682) /Source="Nicolas_upshifts" /id="D1217" /incds=0 /nref=78 /ntot=221 /MaxReadThrough="1.58771" /MaxDrop="5.14851" /score="20.5522057" /energy="-14.7" /TU="NA" /idTUdmin="U1820" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2031043..2031061) /Source="Nicolas_upshift_promotors" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2031056) /Source="Nicolas_upshifts" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2031070..2031075 /Source="Nicolas_upshift_promotors" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2031076..2031082) /Source="Nicolas_upshift_promotors" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2031090..2032012 /Source="Nicolas_S_feature" /locus_tag="new_2432160_2433082" /HighExp="S5, S4, S6, S8, S7, C30, S3, C90, BT, BC" /AntisenseName="sipS" /AntisenseCor="-0.46666993867379197" /AntisenseRegPval="-15.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S882" upshifts 2031090 /Source="Nicolas_upshifts" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2031091..2031109 /Source="Nicolas_upshift_promotors" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2031097..2031112) /Source="Nicolas_upshift_promotors" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2031100) /Source="Nicolas_upshifts" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2031102..2031168) /Source="Nicolas_S_feature" /locus_tag="new_2432172_2432238_c" /HighExp="Etha, T1.30H, M9-stat, T0.30H, M40t90, T2.30H, MG-0.2, MG 15, HiTm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI, SigA" /TUshortPSig="1, 0.994" /TUlongSig="SigA" /TUlongPSig="0.97" /label="S883" promotor_-35 complement(2031125..2031134) /Source="Nicolas_upshift_promotors" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2031163..2031171) /Source="Nicolas_upshift_promotors" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2031168) /Source="Nicolas_upshifts" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2031185..2031193) /Source="Nicolas_upshift_promotors" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2031246..2031800) /gene="sipS" /locus_tag="BSU_23310" /old_locus_tag="BSU23310" /EC_number="3.4.21.89" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8282190, 9325333, 9694797, 9823656, 10198007, 10336490, 10982814, 11004175, 11309398, 15502345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8282190, 9325333, 9694797, 9823656, 10198007, 10336490, 10982814, 11004175, 11309398, 15502345; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_390212.1" /db_xref="EnsemblGenomes-Gn:BSU23310" /db_xref="EnsemblGenomes-Tr:CAB14263" /db_xref="GOA:P28628" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG10515" /db_xref="UniProtKB/Swiss-Prot:P28628" /translation="MKSENVSKKKSILEWAKAIVIAVVLALLIRNFIFAPYVVDGDSM YPTLHNRERVFVNMTVKYIGEFDRGDIVVLNGDDVHYVKRIIGLPGDTVEMKNDQLYI NGKKVDEPYLAANKKRAKQDGFDHLTDDFGPVKVPDNKYFVMGDNRRNSMDSRNGLGL FTKKQIAGTSKFVFYPFNEMRKTN*" /label="sipS CDS" gene complement(2031246..2031800) /gene="sipS" /locus_tag="BSU_23310" /old_locus_tag="BSU23310" /label="sipS gene" downshifts complement(2031256) /Source="Nicolas_upshifts" /id="D1218" /incds=0 /nref=195 /ntot=252 /MaxReadThrough="3.6233" /MaxDrop="7.24702" /score="30.4586783" /energy="-10.9" /TU="U1824" /idTUdmin="U1825" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2031826..2031845) /Source="Nicolas_upshift_promotors" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2031844) /Source="Nicolas_upshifts" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2031846..2032245) /Source="Nicolas_S_feature" /locus_tag="new_2432916_2433315_c" /HighExp="T4.0H, T2.30H, T5.0H, T3.0H, T2.0H, T3.30H, M9-stat, C90, BC, T1.30H" /AntisenseName="ypzC" /AntisenseCor="-0.215992681600812" /AntisenseRegPval="-3.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S884" promotor_-35 complement(2031857..2031863) /Source="Nicolas_upshift_promotors" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2032067..2032303 /gene="ypzC" /locus_tag="BSU_23320" /old_locus_tag="BSU23320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390213.1" /db_xref="EnsemblGenomes-Gn:BSU23320" /db_xref="EnsemblGenomes-Tr:CAB14264" /db_xref="SubtiList:BG13765" /db_xref="UniProtKB/Swiss-Prot:O32012" /translation="MFIYCIPLISQSMIPMALDKTINVMKVTGMFAATYFTGDNRTPF FAFIICLKSFKLENMDQPPKNKSNIFPAVEDSLL*" /label="ypzC CDS" gene 2032067..2032303 /gene="ypzC" /locus_tag="BSU_23320" /old_locus_tag="BSU23320" /label="ypzC gene" CDS complement(2032246..2032452) /gene="ypzJ" /locus_tag="BSU_23328" /old_locus_tag="BSU23328" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097757.1" /db_xref="EnsemblGenomes-Gn:BSU23328" /db_xref="EnsemblGenomes-Tr:CAX52656" /db_xref="InterPro:IPR018652" /db_xref="UniProtKB/Swiss-Prot:C0H447" /translation="MNNKGCIKCGSTEAGQKEIATTGTGLSKLFDVQHNRFLVVYCKN CGYSEFYNKESSTAGNILDLFFGG*" /label="ypzJ CDS" gene complement(2032246..2032452) /gene="ypzJ" /locus_tag="BSU_23328" /old_locus_tag="BSU23328" /label="ypzJ gene" misc_feature complement(2032485..2032504) /Source="Nicolas_upshift_promotors" /id="U1825" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig="0.97002997002997" /xcortree=2780 /SigmaFactorBS="caattagtatgtaatcaaaattaagtaaactttaaagtagta cgggtcattgggattgatattTTGTAGTAAAATAAATCAAAcaaacgtgatgtaatga a" /listShort="ypzJ, S884, sipS" /listLong="S883, ypuD" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2032507) /Source="Nicolas_upshifts" /id="U1825" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig="0.97002997002997" /xcortree=2780 /SigmaFactorBS="caattagtatgtaatcaaaattaagtaaactttaaagtagta cgggtcattgggattgatattTTGTAGTAAAATAAATCAAAcaaacgtgatgtaatga a" /listShort="ypzJ, S884, sipS" /listLong="S883, ypuD" /label="upshifts" CDS complement(2032561..2032815) /gene="ypuC" /locus_tag="BSU_23329" /old_locus_tag="BSU23329" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="fragment of hypothetical protein" /db_xref="PSEUDO:CAX52657.1" /translation="MSFLVFVLIFLFVILTRRVCKLLHFFVYYRFIPHRAEPCVLYEQ YPSDVAAGYAFGGVWLSLNVLVMELFRFSRRFTKLRNEPN*" /label="ypuC CDS" gene complement(2032561..2032815) /gene="ypuC" /locus_tag="BSU_23329" /old_locus_tag="BSU23329" /pseudo /label="ypuC gene" promotor_-35 2032695..2032704 /Source="Nicolas_upshift_promotors" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2032706..2033095) /gene="ypuC" /locus_tag="BSU_23330" /old_locus_tag="BSU23330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 15849754, 16850406" /pseudo /codon_start=1 /transl_table=11 /product="fragment of hypothetical protein" /db_xref="SubtiList:BG10514" /translation="MSYWIGYRLGPAAIQKAFASRGVLLAVIVLTFFWTVFRGQDRKI ELSFLFFLVIGGELYEEGIRRLFHSLHPVHAPLESHVLYPFPSEQTLTAFVIFGFCAY LFVRHSHKTRLQTVAFFCLLSFYSSSG*" /label="ypuC CDS" gene complement(2032706..2033095) /gene="ypuC" /locus_tag="BSU_23330" /old_locus_tag="BSU23330" /pseudo /label="ypuC gene" S_feature 2032718..2033789 /Source="Nicolas_S_feature" /locus_tag="new_2433788_2434859" /HighExp="S6, S8, S7, BT, S5, B36, S4, Pyr, G/S, C30" /AntisenseName="ypuC" /AntisenseCor="0.37168085148262697" /AntisenseRegPval="-9.5" /CDS_PredictionProba="0.69113899999999995" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S885" promotor_-10 2032718..2032737 /Source="Nicolas_upshift_promotors" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2032718 /Source="Nicolas_upshifts" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2033073..2033276) /gene="ypuB" /locus_tag="BSU_23340" /old_locus_tag="BSU23340" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390215.1" /db_xref="EnsemblGenomes-Gn:BSU23340" /db_xref="EnsemblGenomes-Tr:CAB14266" /db_xref="SubtiList:BG10513" /db_xref="UniProtKB/Swiss-Prot:P35151" /translation="MQVLTGLLEQYGYAVLFIVLMLELLALLGPGEFAGVLVFQEKLN WVLSMLAAGLGSCGSEHVVLDRV*" /label="ypuB CDS" gene complement(2033073..2033276) /gene="ypuB" /locus_tag="BSU_23340" /old_locus_tag="BSU23340" /label="ypuB gene" CDS 2033685..2033801 /locus_tag="BSU_23349" /old_locus_tag="BSU23349" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:SOX90572.1" /translation="MYMHFESAQDDPITFARKAAAAFRVVKRIDRYLGFRKL*" /label="hypothetical protein CDS" gene 2033685..2033801 /locus_tag="BSU_23349" /old_locus_tag="BSU23349" /pseudo /label="gene" downshifts 2033752 /Source="Nicolas_upshifts" /id="D1219" /incds=0 /nref=3 /ntot=18 /MaxReadThrough="-0.179729999999999" /MaxDrop="3.76747" /score="-7.5033349" /energy="-9.1" /TU="NA" /idTUdmin="U1826" /TUdmin=198 /isTUend="FALSE" /label="downshifts" promotor_-35 2033878..2033887 /Source="Nicolas_upshift_promotors" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2033900..2033919 /Source="Nicolas_upshift_promotors" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2033900 /Source="Nicolas_upshifts" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="upshifts" CDS 2033942..2034154 /gene="ypzD" /locus_tag="BSU_23350" /old_locus_tag="BSU23350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative germination protein" /protein_id="NP_390216.1" /db_xref="EnsemblGenomes-Gn:BSU23350" /db_xref="EnsemblGenomes-Tr:CAB14267" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13766" /db_xref="UniProtKB/Swiss-Prot:O32013" /translation="MIDYPININNVSGNSVINVGGAFMIRPLTLSKSVFGSGGLNTGI VFENNFVSKAKMINHQFTDQNVTKTF*" /label="ypzD CDS" gene 2033942..2034154 /gene="ypzD" /locus_tag="BSU_23350" /old_locus_tag="BSU23350" /label="ypzD gene" downshifts 2034148 /Source="Nicolas_upshifts" /id="D1220" /incds=0 /nref=4 /ntot=32 /MaxReadThrough="4.9048" /MaxDrop="3.6863" /score="3.56038753" /energy="-6.9" /TU="U1827" /idTUdmin="U1827" /TUdmin="-264" /isTUend="FALSE" /label="downshifts" downshifts complement(2034290) /Source="Nicolas_upshifts" /id="D1221" /incds=0 /nref=254 /ntot=263 /MaxReadThrough="2.52018" /MaxDrop="8.47213" /score="34.3429406" /energy="-12.4" /TU="NA" /idTUdmin="U1828" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2034290..2034721) /gene="ppiB" /locus_tag="BSU_23360" /old_locus_tag="BSU23360" /EC_number="5.2.1.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8639516, 9063446, 9748346, 25184565" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8639516, 9063446, 9748346, 25184565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidyl-prolyl isomerase" /protein_id="NP_390217.1" /db_xref="EnsemblGenomes-Gn:BSU23360" /db_xref="EnsemblGenomes-Tr:CAB14268" /db_xref="GOA:P35137" /db_xref="InterPro:IPR002130" /db_xref="InterPro:IPR020892" /db_xref="InterPro:IPR024936" /db_xref="InterPro:IPR029000" /db_xref="SubtiList:BG10512" /db_xref="UniProtKB/Swiss-Prot:P35137" /translation="MKTGYFLLEDGNKIEFELYPEAAPGTVANFEKLANEGFYDGLTF HRVIPGFVSQGGCPHGTGTGGPGYTIKCETEGNPHTHEAGALSMAHAGKDTGGSQFFI VHEPQPHLNGVHTVFGKVTSGLEFAKNMSNGDVMKEVRVEG*" /label="ppiB CDS" gene complement(2034290..2034721) /gene="ppiB" /locus_tag="BSU_23360" /old_locus_tag="BSU23360" /label="ppiB gene" S_feature complement(2034722..2034808) /Source="Nicolas_S_feature" /locus_tag="new_2435792_2435878_c" /HighExp="dia5, dia15, dia0, Lbexp, LBGtran, C90, Lbtran, HPh, G180, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S886" promotor_-10 complement(2034791..2034810) /Source="Nicolas_upshift_promotors" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2034808) /Source="Nicolas_upshifts" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2034824..2034829) /Source="Nicolas_upshift_promotors" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2034858..2034867 /Source="Nicolas_upshift_promotors" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2034877..2034974 /Source="Nicolas_S_feature" /locus_tag="new_2435947_2436044" /HighExp="Heat, Etha, Salt, dia0, HiTm, T0.30H, B60, Lbexp, T1.0H, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S887" upshifts 2034877 /Source="Nicolas_upshifts" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2034880..2034895 /Source="Nicolas_upshift_promotors" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2034975..2035847 /gene="ypuA" /locus_tag="BSU_23370" /old_locus_tag="BSU23370" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17434969, 18179421, 24706874; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_390218.1" /db_xref="EnsemblGenomes-Gn:BSU23370" /db_xref="EnsemblGenomes-Tr:CAB14269" /db_xref="InterPro:IPR009343" /db_xref="SubtiList:BG10511" /db_xref="UniProtKB/Swiss-Prot:P31847" /translation="MKKIWIGMLAAAVLLLMVPKVSLADAAVGDVIVTLGADLSESDK QKVLDEMNVPDNATTVTVTNKEEHEYLGKYISNAQIGSRAISSSSITIAKKGSGLNVE THNISGITDEMYLNALMTAGVKDAKVYVTAPFEVSGTAALTGLIKAYEVSSDEAISED VKQVANQELVTTSELGDKIGNENAAALIAKIKEEFAKNGVPDNKADIEKQVDDAASDL NVTLTDSQKNQLVSLFNKMKNADIDWGQVSDQLDKAKDKITKFIESDEGKNFIQKVID FFVSIWNAIVSIFK*" /label="ypuA CDS" gene 2034975..2035847 /gene="ypuA" /locus_tag="BSU_23370" /old_locus_tag="BSU23370" /label="ypuA gene" downshifts 2035754 /Source="Nicolas_upshifts" /id="D1222" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="5.9994" /MaxDrop="4.15288" /score="27.7277161" /energy="-12.7" /TU="U1829" /idTUdmin="U1829" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 2035820 /Source="Nicolas_upshifts" /id="D1223" /incds=0 /nref=104 /ntot=219 /MaxReadThrough="1.98749" /MaxDrop="5.95835" /score="27.7277161" /energy="-12.7" /TU="NA" /idTUdmin="U1829" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2035877..2037196) /gene="lysA" /locus_tag="BSU_23380" /old_locus_tag="BSU23380" /EC_number="4.1.1.20" /experiment="publication(s) with functional evidences, PMID:9044297, 14627808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9044297, 14627808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="meso-2,6-diaminopimelate decarboxylase" /protein_id="NP_390219.1" /db_xref="EnsemblGenomes-Gn:BSU23380" /db_xref="EnsemblGenomes-Tr:CAB14270" /db_xref="GOA:P23630" /db_xref="InterPro:IPR000183" /db_xref="InterPro:IPR002986" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR022643" /db_xref="InterPro:IPR022644" /db_xref="InterPro:IPR022653" /db_xref="InterPro:IPR022657" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG10510" /db_xref="UniProtKB/Swiss-Prot:P23630" /translation="MFLHGTSRQNQHGHLEIGGVDALYLAEKYGTPLYVYDVALIRER AKSFKQAFISAGLKAQVAYASKAFSSVAMIQLAEEEGLSLDVVSGGELYTAVAAGFPA ERIHFHGNNKSREELRMALEHRIGCIVVDNFYEIALLEDLCKETGHSIDVLLRITPGV EAHTHDYITTGQEDSKFGFDLHNGQTERAIEQVLQSEHIQLLGVHCHIGSQIFDTAGF VLAAEKIFKKLDEWRDSYSFVSKVLNLGGGFGIRYTEDDEPLHATEYVEKIIEAVKEN ASRYGFDIPEIWIEPGRSLVGDAGTTLYTVGSQKEVPGVRQYVAVDGGMNDNIRPALY QAKYEAAAANRIGEAHDKTVSIAGKCCESGDMLIWDIDLPEVKEGDLLAVFCTGAYGY SMANNYNRIPRPAVVFVENGEAHLVVKRETYEDIVKLDLPFKTGVKQ*" /label="lysA CDS" gene complement(2035877..2037196) /gene="lysA" /locus_tag="BSU_23380" /old_locus_tag="BSU23380" /label="lysA gene" downshifts complement(2035897) /Source="Nicolas_upshifts" /id="D1224" /incds=0 /nref=192 /ntot=251 /MaxReadThrough="2.99445" /MaxDrop="5.13504" /score="28.6775009" /energy="-12.7" /TU="NA" /idTUdmin="U1830" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2037197..2037261) /Source="Nicolas_S_feature" /locus_tag="new_2438267_2438331_c" /HighExp="C90, HiOs, BMM, GM 120, GM 25, MG-0.2, GM 15, GM-0.2, MG t5, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.996, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S888" promotor_-10 complement(2037257..2037276) /Source="Nicolas_upshift_promotors" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2037261) /Source="Nicolas_upshifts" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2037291..2037298) /Source="Nicolas_upshift_promotors" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2037302..2038783) /gene="spoVAF" /locus_tag="BSU_23390" /old_locus_tag="BSU23390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16077113, 17573930, 24682327, 26604257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16077113, 17573930, 24682327, 26604257; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation protein AF" /protein_id="NP_390220.2" /db_xref="EnsemblGenomes-Gn:BSU23390" /db_xref="EnsemblGenomes-Tr:CAB14271" /db_xref="GOA:P31845" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG10508" /db_xref="UniProtKB/Swiss-Prot:P31845" /translation="MPDHKEEKIRVYRNPAKNEEYFKNRVGMGTSYDVGVRKLTILDK EIQLYYLNGLCDTAYIIHLMRELVAINNRKEDPDELVDIVENRLLNAQVEKVKTLDET TDQVLSGLVAVIVEGAGFAFIIDVRSYPGRNPEEPDTEKVVRGARDGFVENIVVNTAL LRRRIRDERLRVKMTKVGERSKTDLSICYIEDIADPDLVEIVEKEIASIDVDGLTMAD KTVEEFIVNQSYNPFPLVRYTERPDVAANHVLEGHVIIIVDTSPSVIITPTTLFHHVQ HAEEYRQAPSVGTFLRWVRFFGILASTLFLPIWFLFVLQPDLLPDNMKFIGLNKDTHI PIILQIFLADLGIEFLRMAAIHTPTALSTAMGLIAAVLIGQIAIEVGLFSPEVILYVS LAAIGTFTTPSYELSLANKMSRLVLMILVALFHIKGLVIGFTVLIIAMASIKSLQTPY LWPLIPFNGKALWQVLVRTAKPGAKVRPSIVHPKNRLRQPTNS*" /label="spoVAF CDS" gene complement(2037302..2038783) /gene="spoVAF" /locus_tag="BSU_23390" /old_locus_tag="BSU23390" /label="spoVAF gene" misc_feature complement(2038008..2038027) /Source="Nicolas_upshift_promotors" /id="U1831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95004995004995" /psig="0.998001998001998" /xcortree=2143 /SigmaFactorBS="tatacagaaagaccggatgtggccgcaaatcatgttctagaa ggcCATGTTATCATTATAGTGGAcacatcgccgagtgtgatcattaccccgacgactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2038012) /Source="Nicolas_upshifts" /id="U1831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95004995004995" /psig="0.998001998001998" /xcortree=2143 /SigmaFactorBS="tatacagaaagaccggatgtggccgcaaatcatgttctagaa ggcCATGTTATCATTATAGTGGAcacatcgccgagtgtgatcattaccccgacgactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2038734..2039345) /gene="spoVAEA" /locus_tag="BSU_23401" /old_locus_tag="BSU23401" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16077113, 17573930, 24682327, 26604257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16077113, 17573930, 24682327, 26604257; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation germinant protein" /protein_id="YP_003097758.1" /db_xref="EnsemblGenomes-Gn:BSU23401" /db_xref="EnsemblGenomes-Tr:CAX52658" /db_xref="GOA:P40870" /db_xref="InterPro:IPR025914" /db_xref="UniProtKB/Swiss-Prot:P40870" /translation="MTTKRKVILVTDGDVYAAKTIEYAASKVGGRCISQSKGNPSTRS GAELVKLIASAPYDPVFVMFDDSGLQGEGPGEAALTYVATHPSIEVLGVIAVASKTHQ AEWTRVDVSIDRNGEITEYGVDKVGEREFDDHRMSGDTVYCLDKLDLPLIVGIGDIGK MGRKDDISKGSPITMKAVEFILERSGYHAGPQGRENSGLSESS*" /label="spoVAEA CDS" gene complement(2038734..2039345) /gene="spoVAEA" /locus_tag="BSU_23401" /old_locus_tag="BSU23401" /label="spoVAEA gene" CDS complement(2039353..2039703) /gene="spoVAEB" /locus_tag="BSU_23402" /old_locus_tag="BSU23402" /experiment="publication(s) with functional evidences, PMID:17573930, 26604257, 27105070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17573930, 26604257, 27105070; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germinant protein" /protein_id="YP_003097759.1" /db_xref="EnsemblGenomes-Gn:BSU23402" /db_xref="EnsemblGenomes-Tr:CAX52659" /db_xref="GOA:C0H450" /db_xref="InterPro:IPR005562" /db_xref="InterPro:IPR014204" /db_xref="UniProtKB/Swiss-Prot:C0H450" /translation="MDYLLAFVCGGAICIVGQLLLDIFKLTPAHVMTSFVVIGAILDG FGIYDKFIEFAGGGATVPIVSFGHSLLHGAMHQAHIHGFIGIGMGIFELTSAGISAAI LFAFIVAVIFKPKG*" /label="spoVAEB CDS" gene complement(2039353..2039703) /gene="spoVAEB" /locus_tag="BSU_23402" /old_locus_tag="BSU23402" /label="spoVAEB gene" CDS complement(2039705..2040721) /gene="spoVAD" /locus_tag="BSU_23410" /old_locus_tag="BSU23410" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16077113, 22328679, 26604257, 27105070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16077113, 22328679, 26604257, 27105070; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation protein AD (uptake of pyridine-2,6-dicarboxylic acid)" /protein_id="NP_390222.1" /db_xref="EnsemblGenomes-Gn:BSU23410" /db_xref="EnsemblGenomes-Tr:CAB14273" /db_xref="GOA:P40869" /db_xref="InterPro:IPR010894" /db_xref="InterPro:IPR016039" /db_xref="PDB:3LM6" /db_xref="SubtiList:BG10895" /db_xref="UniProtKB/Swiss-Prot:P40869" /translation="MKLTGKQTWVFEHPIFVNSAGTAAGPKEKDGPLGSLFDKTYDEM HCNQKSWEMAERQLMEDAVNVALQKNNLTKDDIDLLLAGDLLNQNVTANYVARHLKIP FLCMFGACSTSMETVAVASALVDGGFAKRALAATSSHNATAERQFRYPTEYGGQKPDT ATSTVTGSGAVVISQTPGDIQITSATVGKVSDLGITDPFDMGSAMAPAAADTIKQHFK DLNRTADDYDLILTGDLSGVGSPIVKDILKEDGYPVGTKHDDCGLLIYTPDQQVFAGG SGCACSAVVTYSHIFKQLREGKLNRVFVVATGALLSPTMIQQKETIPTIAHGVVFERA GGAS*" /label="spoVAD CDS" gene complement(2039705..2040721) /gene="spoVAD" /locus_tag="BSU_23410" /old_locus_tag="BSU23410" /label="spoVAD gene" promotor_-35 2040201..2040208 /Source="Nicolas_upshift_promotors" /id="U1832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.987012987012987" /xcortree=627 /SigmaFactorBS="tatcacccggtgtctgaCTGATGACaactgcaccgcttCCGG TTACAGTGGAGGTAGCagtgtccggtttttggcctccgtattctgtcggatagcgaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2040222..2040241 /Source="Nicolas_upshift_promotors" /id="U1832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.987012987012987" /xcortree=627 /SigmaFactorBS="tatcacccggtgtctgaCTGATGACaactgcaccgcttCCGG TTACAGTGGAGGTAGCagtgtccggtttttggcctccgtattctgtcggatagcgaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2040244 /Source="Nicolas_upshifts" /id="U1832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.987012987012987" /xcortree=627 /SigmaFactorBS="tatcacccggtgtctgaCTGATGACaactgcaccgcttCCGG TTACAGTGGAGGTAGCagtgtccggtttttggcctccgtattctgtcggatagcgaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2040734..2041186) /gene="spoVAC" /locus_tag="BSU_23420" /old_locus_tag="BSU23420" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16077113, 16850406, 24666282, 26604257, 27105070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16077113, 16850406, 24666282, 26604257, 27105070; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="mechanosensitive channel; stage V sporulation protein AC" /protein_id="NP_390223.1" /db_xref="EnsemblGenomes-Gn:BSU23420" /db_xref="EnsemblGenomes-Tr:CAB14274" /db_xref="GOA:P40868" /db_xref="InterPro:IPR005562" /db_xref="InterPro:IPR014203" /db_xref="SubtiList:BG10894" /db_xref="UniProtKB/Swiss-Prot:P40868" /translation="MTNIKENYKSKVKTYQPKPPYVWNCVKAFLVGGLICAIGQGLQN FYIHFFDFNEKTAGNPTAATLILISALLTGFGIYDRIGQFAGAGSAVPVTGFANSMAS AALEYKSEGLVLGVATNMFKLAGNVIVFGVVAAYIVGMIRFAFEKLMS*" /label="spoVAC CDS" gene complement(2040734..2041186) /gene="spoVAC" /locus_tag="BSU_23420" /old_locus_tag="BSU23420" /label="spoVAC gene" CDS complement(2041199..2041624) /gene="spoVAB" /locus_tag="BSU_23430" /old_locus_tag="BSU23430" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16077113, 16850406, 26604257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16077113, 16850406, 26604257; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation protein AB" /protein_id="NP_390224.1" /db_xref="EnsemblGenomes-Gn:BSU23430" /db_xref="EnsemblGenomes-Tr:CAB14275" /db_xref="GOA:P40867" /db_xref="InterPro:IPR020144" /db_xref="SubtiList:BG10893" /db_xref="UniProtKB/Swiss-Prot:P40867" /translation="MIVSVLFIIFVGLGGGITVGAGFVAFLTVMGIIPRLMQLTKTMR FVQAYEAAVILGAVCGGWETLHMNHLYLTKWIAVPVGLLAGLFVGMLAAALTEVLNVL PILAKRIGLRSKIIILLMAIVIGKIAGSLFHWLYFIDHS*" /label="spoVAB CDS" gene complement(2041199..2041624) /gene="spoVAB" /locus_tag="BSU_23430" /old_locus_tag="BSU23430" /label="spoVAB gene" CDS complement(2041614..2042234) /gene="spoVAA" /locus_tag="BSU_23440" /old_locus_tag="BSU23440" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:3114420, 26604257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3114420, 26604257; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation protein AA" /protein_id="NP_390225.2" /db_xref="EnsemblGenomes-Gn:BSU23440" /db_xref="EnsemblGenomes-Tr:CAB14276" /db_xref="GOA:P40866" /db_xref="InterPro:IPR021997" /db_xref="SubtiList:BG10892" /db_xref="UniProtKB/Swiss-Prot:P40866" /translation="MERRIFIRLRHRVLAHPGDIITVGDAAQIEGQLQLKKKLSAMPL YQVSEKDKNIVILDIIQVLRAIHLQDPTIDVQTVGGAETIVEIQYRKRNLSTVLFIGV WLLLFIGSCLAIMNFHEDVSMRDVHIALYEIITGERNDYPYLLQIPYSIGLGLGMIVF FNHIFKKRLNEEPSPLEVEMFNYQLDLDQYVAMHENQETIKDLHDR*" /label="spoVAA CDS" gene complement(2041614..2042234) /gene="spoVAA" /locus_tag="BSU_23440" /old_locus_tag="BSU23440" /label="spoVAA gene" promotor_-10 complement(2042265..2042276) /Source="Nicolas_upshift_promotors" /id="U1833" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=924 /SigmaFactorBS="tgtgcaaaagcgtggtaatttatggtcttttcgagcggaTGA ATGAgaacaaaatcgaaCCACATACTACAtatataaccaccgaaagatggtgatcaat g" /listShort="spoVAA, spoVAB, spoVAC, spoVAD, spoVAEB, spoVAEA, spoVAF, S888, lysA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2042275) /Source="Nicolas_upshifts" /id="U1833" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=924 /SigmaFactorBS="tgtgcaaaagcgtggtaatttatggtcttttcgagcggaTGA ATGAgaacaaaatcgaaCCACATACTACAtatataaccaccgaaagatggtgatcaat g" /listShort="spoVAA, spoVAB, spoVAC, spoVAD, spoVAEB, spoVAEA, spoVAF, S888, lysA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2042290..2042296) /Source="Nicolas_upshift_promotors" /id="U1833" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=924 /SigmaFactorBS="tgtgcaaaagcgtggtaatttatggtcttttcgagcggaTGA ATGAgaacaaaatcgaaCCACATACTACAtatataaccaccgaaagatggtgatcaat g" /listShort="spoVAA, spoVAB, spoVAC, spoVAD, spoVAEB, spoVAEA, spoVAF, S888, lysA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2042359..2043126) /gene="sigF" /locus_tag="BSU_23450" /old_locus_tag="BSU23450" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9891799, 15187183, 15205417, 15819616, 16045607, 22115775, 23169620, 24067622, 26506528" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9891799, 15187183, 15205417, 15819616, 16045607, 22115775, 23169620, 24067622, 26506528; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="RNA polymerase sporulation-specific sigma factor(sigma-F)" /protein_id="NP_390226.1" /db_xref="EnsemblGenomes-Gn:BSU23450" /db_xref="EnsemblGenomes-Tr:CAB14277" /db_xref="GOA:P07860" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014236" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014322" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10298" /db_xref="UniProtKB/Swiss-Prot:P07860" /translation="MDVEVKKNGKNAQLKDHEVKELIKQSQNGDQQARDLLIEKNMRL VWSVVQRFLNRGYEPDDLFQIGCIGLLKSVDKFDLTYDVRFSTYAVPMIIGEIQRFIR DDGTVKVSRSLKELGNKIRRAKDELSKTLGRVPTVQEIADHLEIEAEDVVLAQEAVRA PSSIHETVYENDGDPITLLDQIADNSEEKWFDKIALKEAISDLEEREKLIVYLRYYKD QTQSEVAERLGISQVQVSRLEKKILKQIKVQMDHTDG*" /label="sigF CDS" gene complement(2042359..2043126) /gene="sigF" /locus_tag="BSU_23450" /old_locus_tag="BSU23450" /label="sigF gene" downshifts complement(2042389) /Source="Nicolas_upshifts" /id="D1225" /incds=0 /nref=89 /ntot=197 /MaxReadThrough="1.81932" /MaxDrop="7.16571" /score="21.6169221" /energy="-13.5" /TU="NA" /idTUdmin="U1834" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2043138..2043578) /gene="spoIIAB" /locus_tag="BSU_23460" /old_locus_tag="BSU23460" /EC_number="2.7.11.-" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15023063, 15187183, 15819616, 16166546, 16824103, 22115775" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15023063, 15187183, 15819616, 16166546, 16824103, 22115775; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="anti-sigma factor (antagonist of sigma(F)) and serine kinase" /protein_id="NP_390227.1" /db_xref="EnsemblGenomes-Gn:BSU23460" /db_xref="EnsemblGenomes-Tr:CAB14278" /db_xref="GOA:P10728" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR010194" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10297" /db_xref="UniProtKB/Swiss-Prot:P10728" /translation="MKNEMHLEFSALSQNESFARVTVASFIAQLDPTMDELTEIKTVV SEAVTNAIIHGYEENCEGKVYISVTLEDHVVYMTIRDEGLGITDLEEARQPLFTTKPE LERSGMGFTIMENFMDDVSIDSSPEMGTTIRLTKHLSKSKALCN*" /label="spoIIAB CDS" gene complement(2043138..2043578) /gene="spoIIAB" /locus_tag="BSU_23460" /old_locus_tag="BSU23460" /label="spoIIAB gene" CDS complement(2043575..2043928) /gene="spoIIAA" /locus_tag="BSU_23470" /old_locus_tag="BSU23470" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11173484, 15819616, 16824103, 22115775" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11173484, 15819616, 16824103, 22115775; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="anti-anti-sigma factor (antagonist of SpoIIAB)" /protein_id="NP_390228.1" /db_xref="EnsemblGenomes-Gn:BSU23470" /db_xref="EnsemblGenomes-Tr:CAB14279" /db_xref="GOA:P10727" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR003658" /db_xref="InterPro:IPR014237" /db_xref="InterPro:IPR036513" /db_xref="PDB:1AUZ" /db_xref="PDB:1BUZ" /db_xref="SubtiList:BG10296" /db_xref="UniProtKB/Swiss-Prot:P10727" /translation="MSLGIDMNVKESVLCIRLTGELDHHTAETLKQKVTQSLEKDDIR HIVLNLEDLSFMDSSGLGVILGRYKQIKQIGGEMVVCAISPAVKRLFDMSGLFKIIRF EQSEQQALLTLGVAS*" /label="spoIIAA CDS" gene complement(2043575..2043928) /gene="spoIIAA" /locus_tag="BSU_23470" /old_locus_tag="BSU23470" /label="spoIIAA gene" promotor_-10 complement(2043953..2043971) /Source="Nicolas_upshift_promotors" /id="U1834" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=445 /SigmaFactorBS="attatgccgaatgaccactagttttgtcacggtGAAGGAATT cattccgtcgaAATCGAAACACTCATTATCcgatcatatcaaggaggaatgagcatga g" /listShort="spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2043964) /Source="Nicolas_upshifts" /id="U1834" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=445 /SigmaFactorBS="attatgccgaatgaccactagttttgtcacggtGAAGGAATT cattccgtcgaAATCGAAACACTCATTATCcgatcatatcaaggaggaatgagcatga g" /listShort="spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2043966..2044023) /Source="Nicolas_S_feature" /locus_tag="new_2445036_2445093_c" /HighExp="S4, S3, S7, S5, S8, S6, T5.0H, BT, LoTm, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.859" /TUlongSig="NA" /TUlongPSig="NA" /label="S889" promotor_-35 complement(2043983..2043991) /Source="Nicolas_upshift_promotors" /id="U1834" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=445 /SigmaFactorBS="attatgccgaatgaccactagttttgtcacggtGAAGGAATT cattccgtcgaAATCGAAACACTCATTATCcgatcatatcaaggaggaatgagcatga g" /listShort="spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2044024..2045193) /gene="dacF" /locus_tag="BSU_23480" /old_locus_tag="BSU23480" /EC_number="3.4.16.4" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8021191, 8936302, 9864321, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021191, 8936302, 9864321, 19189487; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicilin binding protein)" /protein_id="NP_390229.1" /db_xref="EnsemblGenomes-Gn:BSU23480" /db_xref="EnsemblGenomes-Tr:CAB14280" /db_xref="GOA:P38422" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR015956" /db_xref="InterPro:IPR018044" /db_xref="InterPro:IPR037167" /db_xref="SubtiList:BG10295" /db_xref="UniProtKB/Swiss-Prot:P38422" /translation="MKRLLSTLLIGIMLLTFAPSAFAKQDGKRTSELAHEAKSAVLIE RDTGKVLYNKNSNERLAPASMTKIMTMLLIMEALDKGKIKMSDKVRTSEHAASMGGSQ IFLEPGEEMTVKEMLKGIAIASGNDASVAMAEFISGSEEEFVKKMNKKAKELGLKNTS FKNPTGLTEEGHYSSAYDMAIMAKELLKYESITKFTGTYEDYLRENTDKKFWLVNTNR LIKFYPGVDGVKTGYTGEAKYCLTASAKKGNMRAIAVVFGASTPKERNAQVTKMLDFA FSQYETHPLYKRNQTVAKVKVKKGKQKFIELTTSEPISILTKKGEDMNDVKKEIKMKD NISAPIQKGQELGTLVLKKDGEVLAESPVAAKEDMKKAGFITFLKRTMGDWTKFK*" /label="dacF CDS" gene complement(2044024..2045193) /gene="dacF" /locus_tag="BSU_23480" /old_locus_tag="BSU23480" /label="dacF gene" promotor_-10 complement(2045222..2045233) /Source="Nicolas_upshift_promotors" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2045237) /Source="Nicolas_upshifts" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2045247..2045253) /Source="Nicolas_upshift_promotors" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2045339) /Source="Nicolas_upshifts" /id="D1226" /incds=0 /nref=243 /ntot=267 /MaxReadThrough="0.87114" /MaxDrop="7.5376" /score="26.8559416" /energy="-16.7" /TU="NA" /idTUdmin="U1836" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2045348..2046163) /gene="pupG" /locus_tag="BSU_23490" /old_locus_tag="BSU23490" /EC_number="2.4.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10537218, 15530033, 21279421, 21543875" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10537218, 15530033, 21279421, 21543875; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="purine nucleoside phosphorylase" /protein_id="NP_390230.1" /db_xref="EnsemblGenomes-Gn:BSU23490" /db_xref="EnsemblGenomes-Tr:CAB14281" /db_xref="GOA:P46354" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR011268" /db_xref="InterPro:IPR011270" /db_xref="InterPro:IPR018099" /db_xref="InterPro:IPR035994" /db_xref="SubtiList:BG11330" /db_xref="UniProtKB/Swiss-Prot:P46354" /translation="MKDRIERAAAFIKQNLPESPKIGLILGSGLGILADEIENPVKLK YEDIPEFPVSTVEGHAGQLVLGTLEGVSVIAMQGRFHFYEGYSMEKVTFPVRVMKALG VEALIVTNAAGGVNTEFRAGDLMIITDHINFMGTNPLIGPNEADFGARFPDMSSAYDK DLSSLAEKIAKDLNIPIQKGVYTAVTGPSYETPAEVRFLRTMGSDAVGMSTVPEVIVA NHAGMRVLGISCISNAAAGILDQPLSHDEVMEVTEKVKAGFLKLVKAIVAQYE*" /label="pupG CDS" gene complement(2045348..2046163) /gene="pupG" /locus_tag="BSU_23490" /old_locus_tag="BSU23490" /label="pupG gene" CDS complement(2046176..2047360) /gene="deoB" /locus_tag="BSU_23500" /old_locus_tag="BSU23500" /EC_number="5.4.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10537218, 26211718" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10537218, 26211718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,5-phosphopentomutase" /protein_id="NP_390231.2" /db_xref="EnsemblGenomes-Gn:BSU23500" /db_xref="EnsemblGenomes-Tr:CAB14282" /db_xref="GOA:P46353" /db_xref="InterPro:IPR006124" /db_xref="InterPro:IPR010045" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR024052" /db_xref="SubtiList:BG11331" /db_xref="UniProtKB/Swiss-Prot:P46353" /translation="MPAYKYNRVFLIVMDSVGIGEAPDAADFNDEGAHTLGHIAEHMN GLHMPNMAKLGLGLIEDIKGVEKTEHPLAYYGKMQEASNGKDTMTGHWEIMGLYIDKP FKVFPEGFPDELLQELEKRSGRKIIGNKPASGTAILDELGQEHMETGALIVYTSADSV LQIAAHEEVVPLEELYRICETARELTLDPKYMVGRIIARPFVGEPGQFKRTPNRHDYA LKPFDRTVMNELKDCGLDVISIGKISDIYDGEGITSSRRTVSNMDGMDKVIDTLGEDF TGLSFANLVDFDALFGHRRDPEGYGRALEEFDARLPEVFEKMREDDLLIITADHGNDP IHHGTDHTREYVPILAYSKKHKKAQMLPLADTFADIGATIADNFQTNKPKYGKSFLSL LQ*" /label="deoB CDS" gene complement(2046176..2047360) /gene="deoB" /locus_tag="BSU_23500" /old_locus_tag="BSU23500" /label="deoB gene" promotor_-10 complement(2047409..2047428) /Source="Nicolas_upshift_promotors" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2047427) /Source="Nicolas_upshifts" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2047429..2047520) /Source="Nicolas_S_feature" /locus_tag="new_2448499_2448590_c" /HighExp="S3, S4, M0t90, G180, S7, S8, Glucon, G135, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigEF, SigA" /TUshortPSig="1, 1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S890" promotor_-35 complement(2047444..2047451) /Source="Nicolas_upshift_promotors" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2047521..2048411) /gene="ripX" /locus_tag="BSU_23510" /old_locus_tag="BSU23510" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10498718, 11134515, 11208805, 16553881, 16597952, 21239579, 23305333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498718, 11134515, 11208805, 16553881, 16597952, 21239579, 23305333; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="site-specific tyrosine recombinase for chromosome partitioning" /protein_id="NP_390232.2" /db_xref="EnsemblGenomes-Gn:BSU23510" /db_xref="EnsemblGenomes-Tr:CAB14283" /db_xref="GOA:P46352" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR004107" /db_xref="InterPro:IPR010998" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR011932" /db_xref="InterPro:IPR013762" /db_xref="InterPro:IPR023009" /db_xref="SubtiList:BG11332" /db_xref="UniProtKB/Swiss-Prot:P46352" /translation="MKDQIKDFIHYVMVERGLSQNTIVSYERDLKSYSLYLTETLHVT DWNHVTRIHIIQYLKHLKDSGKSGKTSARHLASIRSFHQFLLREKVTDKDPSVHIETQ KTERALPKVLALNEVERLLDTPKLTSPFGYRDKAMLELLYATGIRVSEMIELKTADVH LSMGFIRCFGKGRKERIVPIGEAAASAIEEYMTKARGKLLKNNVSDALFLNHHGKQIS RQGFWKNLKKIALEAGIKKELTPHTLRHSFATHLLENGADLRAVQEMLGHADISTTQI YTHVTKTRLKDVYKQFHPRA*" /label="ripX CDS" gene complement(2047521..2048411) /gene="ripX" /locus_tag="BSU_23510" /old_locus_tag="BSU23510" /label="ripX gene" CDS complement(2048419..2048646) /gene="yqzK" /locus_tag="BSU_23519" /old_locus_tag="BSU23519" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097760.1" /db_xref="EnsemblGenomes-Gn:BSU23519" /db_xref="EnsemblGenomes-Tr:CAX52660" /db_xref="GOA:C0H451" /db_xref="InterPro:IPR025321" /db_xref="UniProtKB/Swiss-Prot:C0H451" /translation="MGRFLKTAVDALKVFILFTGFTALFYYAMIWVNQEYENYHRYDK PEGSAVKVVEMDQDEKGGWFDRLIFFYQNGE*" /label="yqzK CDS" gene complement(2048419..2048646) /gene="yqzK" /locus_tag="BSU_23519" /old_locus_tag="BSU23519" /label="yqzK gene" promotor_-10 complement(2048549..2048568) /Source="Nicolas_upshift_promotors" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2048560) /Source="Nicolas_upshifts" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2048582..2048589) /Source="Nicolas_upshift_promotors" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2048639) /Source="Nicolas_upshifts" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2048648..2048666) /Source="Nicolas_upshift_promotors" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2048676..2048694) /Source="Nicolas_upshift_promotors" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2048682..2048688) /Source="Nicolas_upshift_promotors" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2048689) /Source="Nicolas_upshifts" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2048711..2048716) /Source="Nicolas_upshift_promotors" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2048771) /Source="Nicolas_upshifts" /id="D1227" /incds=0 /nref=159 /ntot=251 /MaxReadThrough="4.06128" /MaxDrop="5.73495" /score="5.40881961" /energy="-8.1" /TU="U1840" /idTUdmin="U1841" /TUdmin=506 /isTUend="FALSE" /label="downshifts" CDS complement(2048771..2049220) /gene="fur" /locus_tag="BSU_23520" /old_locus_tag="BSU23520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12029044, 12374814, 14563870, 15802251, 16672620, 25160631, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12374814, 14563870, 15802251, 16672620, 25160631, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for iron transport andmetabolism" /protein_id="NP_390233.2" /db_xref="EnsemblGenomes-Gn:BSU23520" /db_xref="EnsemblGenomes-Tr:CAB14284" /db_xref="GOA:P54574" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11766" /db_xref="UniProtKB/Swiss-Prot:P54574" /translation="MENRIDRIKKQLHSSSYKLTPQREATVRVLLENEEDHLSAEDVY LLVKEKSPEIGLATVYRTLELLTELKVVDKINFGDGVSRYDLRKEGAAHFHHHLVCME CGAVDEIEEDLLEDVEEIIERDWKFKIKDHRLTFHGICHRCNGKETE*" /label="fur CDS" gene complement(2048771..2049220) /gene="fur" /locus_tag="BSU_23520" /old_locus_tag="BSU23520" /label="fur gene" promotor_-10 complement(2049244..2049263) /Source="Nicolas_upshift_promotors" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="promotor_-10" upshifts complement(2049254) /Source="Nicolas_upshifts" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="upshifts" S_feature complement(2049256..2049332) /Source="Nicolas_S_feature" /locus_tag="new_2450326_2450402_c" /HighExp="S3, S4, S5, BT, LoTm, M9-stat, T5.0H, T3.30H, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S891" promotor_-35 complement(2049279..2049283) /Source="Nicolas_upshift_promotors" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="promotor_-35" CDS complement(2049333..2049977) /gene="spoIIM" /locus_tag="BSU_23530" /old_locus_tag="BSU23530" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17376078, 17824930, 20382772, 23859254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17376078, 17824930, 20382772, 23859254; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="autolysin component for dissolution of the septal cell wall (stage II sporulation)" /protein_id="NP_390234.1" /db_xref="EnsemblGenomes-Gn:BSU23530" /db_xref="EnsemblGenomes-Tr:CAB14285" /db_xref="GOA:P37873" /db_xref="InterPro:IPR002798" /db_xref="InterPro:IPR014196" /db_xref="SubtiList:BG10768" /db_xref="UniProtKB/Swiss-Prot:P37873" /translation="MRKISYKDMFLRHVKDHLSLYIFVSVLFFMGVIFGAIIVNSMTI SQKEDLYYYLSQFFGQLSDGKQASSADMFGQSIFHNAKYLGLMWILGISVIGMPIIFI MIFLKGIVVGFTVGFLVNQMGVSGFFLSFVSVLPQNVLLIPAYLIMGTCAIAFSLKLI RQLFVKRSLHDAPIQWFGRYAFVLLVILFLALISSLFEAYLSPVLMEKLTSRLF*" /label="spoIIM CDS" gene complement(2049333..2049977) /gene="spoIIM" /locus_tag="BSU_23530" /old_locus_tag="BSU23530" /label="spoIIM gene" promotor_-10 complement(2050008..2050026) /Source="Nicolas_upshift_promotors" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="promotor_-10" upshifts complement(2050025) /Source="Nicolas_upshifts" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="upshifts" promotor_-35 complement(2050041..2050046) /Source="Nicolas_upshift_promotors" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="promotor_-35" CDS complement(2050078..2050293) /gene="yqkK" /locus_tag="BSU_23540" /old_locus_tag="BSU23540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390235.1" /db_xref="EnsemblGenomes-Gn:BSU23540" /db_xref="EnsemblGenomes-Tr:CAB14286" /db_xref="SubtiList:BG11765" /db_xref="UniProtKB/Swiss-Prot:P54573" /translation="MAKSQAKKKRGHRLRNGGRDVLLSRGSTPSFSTHGRMTKSKKEI LNKRKHKNPYDHTAVDDKDFFVPQKAA*" /label="yqkK CDS" gene complement(2050078..2050293) /gene="yqkK" /locus_tag="BSU_23540" /old_locus_tag="BSU23540" /label="yqkK gene" downshifts complement(2050158) /Source="Nicolas_upshifts" /id="D1228" /incds=1 /nref=17 /ntot=130 /MaxReadThrough="0.857610000000001" /MaxDrop="3.7055" /score="1.77181315" /energy="-9.8" /TU="NA" /idTUdmin="U1842" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2050393..2051712) /gene="mleA" /locus_tag="BSU_23550" /old_locus_tag="BSU23550" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 23136871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 23136871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catabolic NAD-dependent malic enzyme (conversionof malate into pyruvate)" /protein_id="NP_390236.1" /db_xref="EnsemblGenomes-Gn:BSU23550" /db_xref="EnsemblGenomes-Tr:CAB14287" /db_xref="GOA:P54572" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG11764" /db_xref="UniProtKB/Swiss-Prot:P54572" /translation="MIAKHMIRTLMIETPSVPGNLGRVATAIGLLGGDIGEVETVKVG PNYTMRNITVQVENEEQLQEVIAAVQALGEGIRLHTVSDEVLSAHEGGKIQMKSKMPI RSLAELGRVYTPGVADVCRLIEKEPEKASIYTTISNSVAIVTDGTAILGLGNIGSVAG MPVMEGKAALFDQLAGISGIPILLDTSDPEEIIKTVKHISPGFSGILLEDIGSPHCFE IEDRLKEELNIPVMHDDQHGTAVVTLAAAISACRSAGVDLKEAKVGQIGLGAAGVAIC RMFMAYGVNAVYGTDKSESAMNRLEQYGGQAVSSIEELMETCDIVIATTGVPGLIKPA FVRSGQVILALSNPKPEIEPEAALQAGAAYAADGRSVNNVLGFPGIFRGALNAKSTEI NHDMLVAAAEAIAACTKQGDVVPQPLDSKVHHAVAAAVEHAALTAVK*" /label="mleA CDS" gene complement(2050393..2051712) /gene="mleA" /locus_tag="BSU_23550" /old_locus_tag="BSU23550" /label="mleA gene" downshifts complement(2050400) /Source="Nicolas_upshifts" /id="D1229" /incds=0 /nref=29 /ntot=84 /MaxReadThrough="3.50516" /MaxDrop="5.65279" /score="42.1653011" /energy="-15.2" /TU="U1842,U1843" /idTUdmin="U1842" /TUdmin="-243" /isTUend="FALSE" /label="downshifts" CDS complement(2051730..2053136) /gene="mleN" /locus_tag="BSU_23560" /old_locus_tag="BSU23560" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10903309, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10903309, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="malate-H+/Na+-lactate antiporter" /protein_id="NP_390237.1" /db_xref="EnsemblGenomes-Gn:BSU23560" /db_xref="EnsemblGenomes-Tr:CAB14288" /db_xref="GOA:P54571" /db_xref="InterPro:IPR004770" /db_xref="InterPro:IPR018461" /db_xref="SubtiList:BG11763" /db_xref="UniProtKB/Swiss-Prot:P54571" /translation="MKDVRLPTLFEIIIVLGVFLALVLSFTVFLDLPIQLALFVSWFI AMLLGIRLGYSYKDLQNAIVHGISNGLEAVLILVSVGALIGTWIAGGVVPTLIYYGLE FIHPSIFLLATLIICSIMSVATGTSWGTVGTAGIAMIAIGEGLGIPLPLVAGAILSGA YFGDKLSPLSDSTVLASSLSKVDVLAHVRAMLYLSIPAYVITAILFTVVGFMYGGKNI DLDKVEFLKSSLQNTFDIHIWMLIPAVLVIVLLAMKKPSMPVIVIGALLGAIWAVVFQ GMDIAHAIATAYNGFSIKTDVEFLNGLLNRGGIVGMLDSLVVIIFGLGFGGLLEKLGV LKVIVSTFEKKLTSAGNVTLSTLIVAFLANIFGCAMYVSLILTPKIMEDSYDRLHLDR RVLSRNSEVGGTLTSGMVPWSDNGIYMAGILGVSTFSYLPFMWLSFVAIGLAIIYGYT GKFIWYTKNNTVKAEKLG*" /label="mleN CDS" gene complement(2051730..2053136) /gene="mleN" /locus_tag="BSU_23560" /old_locus_tag="BSU23560" /label="mleN gene" promotor_-10 complement(2053184..2053203) /Source="Nicolas_upshift_promotors" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2053193) /Source="Nicolas_upshifts" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2053195..2053276) /Source="Nicolas_S_feature" /locus_tag="new_2454265_2454346_c" /HighExp="S0, dia0, dia5, Lbexp, G150, Oxctl, G135, Mt0, Paraq, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S892" promotor_-35 complement(2053218..2053225) /Source="Nicolas_upshift_promotors" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2053277..2054704) /gene="ansB" /locus_tag="BSU_23570" /old_locus_tag="BSU23570" /EC_number="4.3.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1711029" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1711029; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="L-aspartase (aspartate ammonia lyase)" /protein_id="NP_390238.2" /db_xref="EnsemblGenomes-Gn:BSU23570" /db_xref="EnsemblGenomes-Tr:CAB14289" /db_xref="GOA:P26899" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR004708" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR018951" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10301" /db_xref="UniProtKB/Swiss-Prot:P26899" /translation="MLNGQKEYRVEKDFLGEKQIEADVYYGIQTLRASENFPITGYKI HEEMINALAIVKKAAALANMDVKRLYEGIGQAIVQAADEILEGKWHDQFIVDPIQGGA GTSMNMNANEVIGNRALEIMGHKKGDYIHLSPNTHVNMSQSTNDVFPTAIHISTLKLL EKLLKTMEDMHSVFKQKAQEFDSVIKMGRTHLQDAVPIRLGQEFEAYSRVLERDIKRI KQSRQHLYEVNMGATAVGTGLNADPEYIKQVVKHLADISGLPLVGADHLVDATQNTDA YTEVSASLKVCMMNMSKIANDLRLMASGPRAGLAEISLPARQPGSSIMPGKVNPVMAE LINQIAFQVIGNDNTICLASEAGQLELNVMEPVLVFNLLQSISIMNNGFRSFTDNCLK GIEANEKRMKQYVEKSAGVITAVNPHLGYEAAARIAREAIMTGQSVRDLCLQHDVLTE EELDIILNPYEMTKPGIAGKELLEK*" /label="ansB CDS" gene complement(2053277..2054704) /gene="ansB" /locus_tag="BSU_23570" /old_locus_tag="BSU23570" /label="ansB gene" CDS complement(2054749..2055738) /gene="ansA" /locus_tag="BSU_23580" /old_locus_tag="BSU23580" /EC_number="3.5.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1711029, 11914346, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1711029, 11914346, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported L-asparaginase" /protein_id="NP_390239.1" /db_xref="EnsemblGenomes-Gn:BSU23580" /db_xref="EnsemblGenomes-Tr:CAB14290" /db_xref="GOA:P26900" /db_xref="InterPro:IPR006033" /db_xref="InterPro:IPR006034" /db_xref="InterPro:IPR020827" /db_xref="InterPro:IPR027473" /db_xref="InterPro:IPR027474" /db_xref="InterPro:IPR027475" /db_xref="InterPro:IPR036152" /db_xref="InterPro:IPR037152" /db_xref="SubtiList:BG10300" /db_xref="UniProtKB/Swiss-Prot:P26900" /translation="MKKLLMLTTGGTIASVEGENGLAPGVKADELLSYVSKLDNDYTM ETQSLMNIDSTNMQPEYWVEIAEAVKENYDAYDGFVITHGTDTMAYTSAALSYMLQHA KKPIVITGSQIPITFQKTDAKKNITDAIRFACEGVGGVYVVFDGRVIQGTRAIKLRTK SYDAFESINYPYIAFINEDGIEYNKQVTEPENDTFTVDTSLCTDVCLLKLHPGLKPEM FDALKSMYKGIVIESYGSGGVPFEGRDILSKVNELIESGIVVVITTQCLEEGEDMSIY EVGRRVNQDLIIRSRNMNTEAIVPKLMWALGQSSDLPVVKRIMETPIADDVVL*" /label="ansA CDS" gene complement(2054749..2055738) /gene="ansA" /locus_tag="BSU_23580" /old_locus_tag="BSU23580" /label="ansA gene" S_feature complement(2055739..2055818) /Source="Nicolas_S_feature" /locus_tag="new_2456809_2456888_c" /HighExp="dia0, Lbexp, G150, Oxctl, dia5, LBGexp, Paraq, C30, G180, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S893" promotor_-10 complement(2055800..2055819) /Source="Nicolas_upshift_promotors" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2055818) /Source="Nicolas_upshifts" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2055820..2056140) /Source="Nicolas_S_feature" /locus_tag="new_2456890_2457210_c" /HighExp="LBGstat, S5, G135, S8, S6, LBGtran, G180, G150, LoTm, LBGexp" /AntisenseName="ansR" /AntisenseCor="0.23077291929287899" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S894" promotor_-35 complement(2055834..2055841) /Source="Nicolas_upshift_promotors" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2055859..2055866 /Source="Nicolas_upshift_promotors" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2055879..2055898 /Source="Nicolas_upshift_promotors" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2055881 /Source="Nicolas_upshifts" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="upshifts" CDS 2055920..2056270 /gene="ansR" /locus_tag="BSU_23590" /old_locus_tag="BSU23590" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11914346" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914346; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of ansAB (Xre family)" /protein_id="NP_390240.1" /db_xref="EnsemblGenomes-Gn:BSU23590" /db_xref="EnsemblGenomes-Tr:CAB14291" /db_xref="GOA:Q07683" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR027910" /db_xref="SubtiList:BG10299" /db_xref="UniProtKB/Swiss-Prot:Q07683" /translation="MNLDRLTELRKKKNWSLQYTADLLGIAKSTYAGYESGYRRPSLE ALAMLADLFDTTCDELLGREKQKQTAPQAIELATWSSLDFTISVDGQPLSEDEIIQLI TFIRTKRKVQEELS*" /label="ansR CDS" gene 2055920..2056270 /gene="ansR" /locus_tag="BSU_23590" /old_locus_tag="BSU23590" /label="ansR gene" S_feature complement(2056142..2056278) /Source="Nicolas_S_feature" /locus_tag="new_2457212_2457348_c" /HighExp="LBGstat, S8, S6, S7, S5, ferm, nit, LBGtran, BT, LPhT" /AntisenseName="ansR" /AntisenseCor="-0.22421651781702501" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S895" downshifts complement(2056185) /Source="Nicolas_upshifts" /id="D1230" /incds=1 /nref=4 /ntot=116 /MaxReadThrough="3.90926" /MaxDrop="4.76642" /score="10.2434094" /energy="-23.6" /TU="U1847" /idTUdmin="U1845" /TUdmin=1451 /isTUend="FALSE" /label="downshifts" CDS complement(2056279..2057442) /gene="yqxK" /locus_tag="BSU_23600" /old_locus_tag="BSU23600" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleotide binding protein" /protein_id="NP_390241.2" /db_xref="EnsemblGenomes-Gn:BSU23600" /db_xref="EnsemblGenomes-Tr:CAB14292" /db_xref="GOA:P38423" /db_xref="InterPro:IPR005287" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR016195" /db_xref="SubtiList:BG11073" /db_xref="UniProtKB/Swiss-Prot:P38423" /translation="MKKIYADLHIHIGRTFTGRAVKITGAKTLTLDRILVEASEHKGI ELLGIIDCHSPEVILELEEGISSGKYRELDGGGIRYRSTTLLLGSELEIYDEACSGPI HVLVFMPTLADMKQFSNWLSARLKNIHLSSQRIYETGLNLQKKVQDMGGLFIPAHIFT PHKSLYGKGVKSSLTEVFDPSMIDAVELGLSCDTDMASHVSQLNPYPFLTNSDAHSLG KIGREYNELYVQSADFTEFALALKGQDDRKIIANYGLDPLLGKYYQTACEACGEPAVS GETACANCGKARFTKGVSDRLRELSDQLEVRVPRPRYVHQIPLQFVPGVGPKTLDKLK KAFGTEMAVLHEAAEEDLARVVPPKTAALIVKARSGKLELKAGGGGTYGKIKP*" /label="yqxK CDS" gene complement(2056279..2057442) /gene="yqxK" /locus_tag="BSU_23600" /old_locus_tag="BSU23600" /label="yqxK gene" CDS complement(2057439..2057996) /gene="nudF" /locus_tag="BSU_23610" /old_locus_tag="BSU23610" /EC_number="3.1.7.1" /EC_number="3.6.1.13" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10542272, 17693564, 21638333, 25212876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isopentenyl pyrophosphate and dimethylallyl pyrophosphate diphosphatase (moonlighting ADP-ribose pyrophosphatase)" /protein_id="NP_390242.1" /db_xref="EnsemblGenomes-Gn:BSU23610" /db_xref="EnsemblGenomes-Tr:CAB14293" /db_xref="GOA:P54570" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG11762" /db_xref="UniProtKB/Swiss-Prot:P54570" /translation="MKSLEEKTIAKEQIFSGKVIDLYVEDVELPNGKASKREIVKHPG AVAVLAVTDEGKIIMVKQFRKPLERTIVEIPAGKLEKGEEPEYTALRELEEETGYTAK KLTKITAFYTSPGFADEIVHVFLAEELSVLEEKRELDEDEFVEVMEVTLEDALKLVES REVYDAKTAYAIQYLQLKEALQAQK*" /label="nudF CDS" gene complement(2057439..2057996) /gene="nudF" /locus_tag="BSU_23610" /old_locus_tag="BSU23610" /label="nudF gene" promotor_no_box complement(2057926..2058026) /Source="Nicolas_upshift_promotors" /id="U1845" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.688311688311688" /psig="0.01998001998002" /xcortree=1733 /SigmaFactorBS="tcatatagagacagaacgggagatgaagaaatgaaatcatta gaagaaaaaacaattgccaaagaacagattttttcgggtaaagtcattgatctttatg t" /listShort="nudF" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2057966) /Source="Nicolas_upshifts" /id="U1845" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.688311688311688" /psig="0.01998001998002" /xcortree=1733 /SigmaFactorBS="tcatatagagacagaacgggagatgaagaaatgaaatcatta gaagaaaaaacaattgccaaagaacagattttttcgggtaaagtcattgatctttatg t" /listShort="nudF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2058010..2058015 /Source="Nicolas_upshift_promotors" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2058031..2058049 /Source="Nicolas_upshift_promotors" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2058033..2058047) /Source="Nicolas_upshift_promotors" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="promotor_-10" upshifts 2058037 /Source="Nicolas_upshifts" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="upshifts" S_feature 2058044..2058218 /Source="Nicolas_S_feature" /locus_tag="new_2459114_2459288" /HighExp="S4, S5, S3, S7, S6, LoTm, BT, T5.0H, G/S, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99962399999999996" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S896" promotor_-35 complement(2058049..2058052) /Source="Nicolas_upshift_promotors" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="promotor_-35" upshifts complement(2058052) /Source="Nicolas_upshifts" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="upshifts" CDS 2058071..2058193 /gene="mciZ" /locus_tag="BSU_23616" /old_locus_tag="BSU23616" /function="15.1: Cell division" /experiment="publication(s) with functional evidences, PMID:18284588, 23237472, 25848052, 27752253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18284588, 23237472, 25848052, 27752253; Product type f: factor" /codon_start=1 /transl_table=11 /product="cell division inhibitor" /protein_id="YP_009513976.1" /db_xref="EnsemblGenomes-Gn:BSU23616" /db_xref="EnsemblGenomes-Tr:CCQ48600" /db_xref="GOA:L8EBJ9" /db_xref="InterPro:IPR025177" /db_xref="PDB:2MRW" /db_xref="PDB:4U39" /db_xref="UniProtKB/TrEMBL:L8EBJ9" /translation="MKVHRMPKGVVLVGKAWEIRAKLKEYGRTFQYVKDWISKP*" /label="mciZ CDS" gene 2058071..2058193 /gene="mciZ" /locus_tag="BSU_23616" /old_locus_tag="BSU23616" /label="mciZ gene" promotor_-35 2058194..2058201 /Source="Nicolas_upshift_promotors" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2058215..2058234 /Source="Nicolas_upshift_promotors" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2058220 /Source="Nicolas_upshifts" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="upshifts" CDS 2058256..2059176 /gene="yqkF" /locus_tag="BSU_23620" /old_locus_tag="BSU23620" /EC_number="1.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 9643546, 15317791, 16242712, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent aldo-keto reductase (acts on 4-hydroxy-2,3-trans-nonenal)" /protein_id="NP_390243.1" /db_xref="EnsemblGenomes-Gn:BSU23620" /db_xref="EnsemblGenomes-Tr:CAB14294" /db_xref="GOA:P54569" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11761" /db_xref="UniProtKB/Swiss-Prot:P54569" /translation="MRKRKLGTSDLDISEVGLGCMSLGTEKNKALSILDEAIELGINY LDTADLYDRGRNEEIVGDAIQNRRHDIILATKAGNRWDDGSEGWYWDPSKAYIKEAVK KSLTRLKTDYIDLYQLHGGTIEDNIDETIEAFEELKQEGVIRYYGISSIRPNVIKEYV KKSNIVSIMMQFSLFDRRPEEWLPLLEEHQISVVARGPVAKGLLTEKPLDQASESMKQ NGYLSYSFEELTNARKAMEEVAPDLSMTEKSLQYLLAQPAVASVITGASKIEQLRENI QAANARRLTEEEIKALQSHTKQDIYKAHRS*" /label="yqkF CDS" gene 2058256..2059176 /gene="yqkF" /locus_tag="BSU_23620" /old_locus_tag="BSU23620" /label="yqkF gene" downshifts 2059165 /Source="Nicolas_upshifts" /id="D1231" /incds=0 /nref=186 /ntot=248 /MaxReadThrough="1.49159" /MaxDrop="5.81013" /score="18.6018806" /energy="-14.8" /TU="NA" /idTUdmin="U1846" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2059208..2059432) /gene="yqkE" /locus_tag="BSU_23630" /old_locus_tag="BSU23630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390244.1" /db_xref="EnsemblGenomes-Gn:BSU23630" /db_xref="EnsemblGenomes-Tr:CAB14295" /db_xref="InterPro:IPR024980" /db_xref="SubtiList:BG11760" /db_xref="UniProtKB/Swiss-Prot:P54568" /translation="MKKQKSIDKHQLKDGLQSDIKAKLMEMKSQLKEEDEKRQKREKA EQIRKKKEIEKNKSFEELLNESQMDWHQYK*" /label="yqkE CDS" gene complement(2059208..2059432) /gene="yqkE" /locus_tag="BSU_23630" /old_locus_tag="BSU23630" /label="yqkE gene" downshifts complement(2059265) /Source="Nicolas_upshifts" /id="D1232" /incds=0 /nref=19 /ntot=195 /MaxReadThrough="0.59953" /MaxDrop="5.9087" /score="15.8160537" /energy="-13" /TU="NA" /idTUdmin="U1849" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2059455..2059474) /Source="Nicolas_upshift_promotors" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2059462) /Source="Nicolas_upshifts" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2059489..2059496) /Source="Nicolas_upshift_promotors" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2059511..2059518 /Source="Nicolas_upshift_promotors" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2059533..2059552 /Source="Nicolas_upshift_promotors" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2059540 /Source="Nicolas_upshifts" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="upshifts" CDS 2059594..2060511 /gene="yqkD" /locus_tag="BSU_23640" /old_locus_tag="BSU23640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390245.1" /db_xref="EnsemblGenomes-Gn:BSU23640" /db_xref="EnsemblGenomes-Tr:CAB14296" /db_xref="GOA:P54567" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11759" /db_xref="UniProtKB/Swiss-Prot:P54567" /translation="MKKILLAIGALVTAVIAIGIVFSHMILFIKKKTDEDIIKRETDN GHDVFESFEQMEKTAFVIPSAYGYDIKGYHVAPHDTPNTIIICHGVTMNVLNSLKYMH LFLDLGWNVLIYDHRRHGQSGGKTTSYGFYEKDDLNKVVSLLKNKTNHRGLIGIHGES MGAVTALLYAGAHCSDGADFYIADCPFACFDEQLAYRLRAEYRLPSWPLLPIADFFLK LRGGYRAREVSPLAVIDKIEKPVLFIHSKDDDYIPVSSTERLYEKKRGPKALYIAENG EHAMSYTKNRHTYRKTVQEFLDNMNDSTE*" /label="yqkD CDS" gene 2059594..2060511 /gene="yqkD" /locus_tag="BSU_23640" /old_locus_tag="BSU23640" /label="yqkD gene" downshifts 2060486 /Source="Nicolas_upshifts" /id="D1233" /incds=0 /nref=27 /ntot=171 /MaxReadThrough="2.02201" /MaxDrop="3.99393" /score="14.106821" /energy="-11.8" /TU="NA" /idTUdmin="U1850" /TUdmin=594 /isTUend="FALSE" /label="downshifts" CDS complement(2060551..2060790) /gene="yqkC" /locus_tag="BSU_23650" /old_locus_tag="BSU23650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390246.1" /db_xref="EnsemblGenomes-Gn:BSU23650" /db_xref="EnsemblGenomes-Tr:CAB14297" /db_xref="InterPro:IPR020157" /db_xref="SubtiList:BG11758" /db_xref="UniProtKB/Swiss-Prot:P54566" /translation="MEQKLKAMKNTAQNKTWVSFLNQNHPYTLLHWSIGGAESIKKDV WLLQDEMTFETQEFTTIDLAIEWIRENMDGITDVL*" /label="yqkC CDS" gene complement(2060551..2060790) /gene="yqkC" /locus_tag="BSU_23650" /old_locus_tag="BSU23650" /label="yqkC gene" downshifts complement(2060562) /Source="Nicolas_upshifts" /id="D1234" /incds=0 /nref=215 /ntot=269 /MaxReadThrough="3.31829" /MaxDrop="6.35785" /score="16.3526162" /energy="-11.2" /TU="NA" /idTUdmin="U1851" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2060803..2061126) /gene="yqkB" /locus_tag="BSU_23660" /old_locus_tag="BSU23660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390247.1" /db_xref="EnsemblGenomes-Gn:BSU23660" /db_xref="EnsemblGenomes-Tr:CAB14298" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG11757" /db_xref="UniProtKB/Swiss-Prot:P54565" /translation="MNIHVTDAAKQALQQAFDANPGKKAQLRYDAEGCGCAVSGVPTI WLAEELTGQCEQLETNGIPLYIQSSQKVFFDDQMTIDYNEKAKTLALKSPAEMLSPRM SILVK*" /label="yqkB CDS" gene complement(2060803..2061126) /gene="yqkB" /locus_tag="BSU_23660" /old_locus_tag="BSU23660" /label="yqkB gene" promotor_-10 complement(2060869..2060888) /Source="Nicolas_upshift_promotors" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2060870) /Source="Nicolas_upshifts" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2060902..2060909) /Source="Nicolas_upshift_promotors" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2061123..2062154) /gene="yqkA" /locus_tag="BSU_23670" /old_locus_tag="BSU23670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390248.1" /db_xref="EnsemblGenomes-Gn:BSU23670" /db_xref="EnsemblGenomes-Tr:CAB14299" /db_xref="GOA:P54564" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR007344" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11756" /db_xref="UniProtKB/Swiss-Prot:P54564" /translation="MIEFLQHKEATIAREILAVQIPAYIKETEIIGFDGIPALQEKVK DIQASHERFAGYRKNGKLIGVISYEKNMHYLTICRLVVHPDGFRKGIGRALLQFVIDH NEDAEKIEVVTAENNTPAVSLYTQAGFQKAETVKAAQGLLLSVFHLYPKRKVEIILYN EKWAECFDEEKERLKLVFGPEIIAIHHIGSTSIPNMAAKPIIDMLIEVRSIEAVSQFD EQMKANGYTPKGENGIAGRRYFQKGGNKRTHHVHMYEQGNPAIERHLLFRDYLRAHPN IAKEYAVLKKQLAAQHPDSINQYIQGKDEWIKTAEENAKRWKKGRNNANGSIVCYNSE NDENGGFTL*" /label="yqkA CDS" gene complement(2061123..2062154) /gene="yqkA" /locus_tag="BSU_23670" /old_locus_tag="BSU23670" /label="yqkA gene" promotor_-10 complement(2061150..2061169) /Source="Nicolas_upshift_promotors" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2061157) /Source="Nicolas_upshifts" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2061180..2061187) /Source="Nicolas_upshift_promotors" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2062147..2062491) /gene="yqjZ" /locus_tag="BSU_23680" /old_locus_tag="BSU23680" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative degradation enzyme (oxygenase)" /protein_id="NP_390249.1" /db_xref="EnsemblGenomes-Gn:BSU23680" /db_xref="EnsemblGenomes-Tr:CAB14300" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:2GO8" /db_xref="SubtiList:BG11755" /db_xref="UniProtKB/Swiss-Prot:P54563" /translation="MMDFLSKTPEPPYYAVIFSSVKSENDTGYGETAERMVSLAADQP GFLGVESVREADGRGITVSYWDSMDAINHWRHHTEHQAAKEKGRSVWYESYAVRVAKV DRQRLFQENTND*" /label="yqjZ CDS" gene complement(2062147..2062491) /gene="yqjZ" /locus_tag="BSU_23680" /old_locus_tag="BSU23680" /label="yqjZ gene" CDS complement(2062501..2062971) /gene="yqjY" /locus_tag="BSU_23690" /old_locus_tag="BSU23690" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390250.1" /db_xref="EnsemblGenomes-Gn:BSU23690" /db_xref="EnsemblGenomes-Tr:CAB14301" /db_xref="GOA:P54562" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR017255" /db_xref="PDB:1MK4" /db_xref="SubtiList:BG11754" /db_xref="UniProtKB/Swiss-Prot:P54562" /translation="MDIRTITSSDYEMVTSVLNEWWGGRQLKEKLPRLFFEHFQDTSF ITSEHNSMTGFLIGFQSQSDPETAYIHFSGVHPDFRKMQIGKQLYDVFIETVKQRGCT RVKCVTSPVNKVSIAYHTKLGFDIEKGTKTVNGISVFANYDGPGQDRVLFVKNI*" /label="yqjY CDS" gene complement(2062501..2062971) /gene="yqjY" /locus_tag="BSU_23690" /old_locus_tag="BSU23690" /label="yqjY gene" S_feature complement(2062972..2063048) /Source="Nicolas_S_feature" /locus_tag="new_2464042_2464118_c" /HighExp="SMM, T-4.40H, MG 150, M9-tran, GM 90, T-3.40H, GM-0.2, M9-exp, GM 120, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigEF" /TUlongPSig="0.776" /label="S897" downshifts 2062972 /Source="Nicolas_upshifts" /id="D1235" /incds=0 /nref=8 /ntot=121 /MaxReadThrough="0.87367" /MaxDrop="3.61005" /score="-1.04904304" /energy="-6.5" /TU="NA" /idTUdmin="U1854" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2063023..2063042) /Source="Nicolas_upshift_promotors" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2063048) /Source="Nicolas_upshifts" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2063050..2063156) /Source="Nicolas_S_feature" /locus_tag="new_2464120_2464226_c" /HighExp="M40t90, S4, M40t45, S6, H2O2, S5, S3, S8, S7, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.776" /TUlongSig="NA" /TUlongPSig="NA" /label="S898" promotor_-35 complement(2063057..2063064) /Source="Nicolas_upshift_promotors" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2063157..2063495) /gene="yqjX" /locus_tag="BSU_23700" /old_locus_tag="BSU23700" /function="16.8: Protect" /function="16.5: Explore" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12137951, 16267290" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390251.1" /db_xref="EnsemblGenomes-Gn:BSU23700" /db_xref="EnsemblGenomes-Tr:CAB14302" /db_xref="GOA:P54561" /db_xref="InterPro:IPR014962" /db_xref="SubtiList:BG11753" /db_xref="UniProtKB/Swiss-Prot:P54561" /translation="MNDHLKRGNLLWEGSRMFLPEHKQSLLERKRLKQKLQKPILDPD KLEEMNQTLCAAMEFAQDITVSCFQDGEIVCCTGKICRYEEFEKAVWIKGDEDQLYKL KLDQVLDIVL*" /label="yqjX CDS" gene complement(2063157..2063495) /gene="yqjX" /locus_tag="BSU_23700" /old_locus_tag="BSU23700" /label="yqjX gene" CDS complement(2063492..2064730) /gene="polYB" /locus_tag="BSU_23710" /old_locus_tag="BSU23710" /EC_number="2.7.7.7" /function="16.5: Explore" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12137951, 12644484, 15469515, 16045613, 16267290, 19924481, 24118570" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12137951, 12644484, 15469515, 16045613, 16267290, 19924481, 24118570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Y family DNA polymerase V bypassing lesions during replication" /protein_id="NP_390252.1" /db_xref="EnsemblGenomes-Gn:BSU23710" /db_xref="EnsemblGenomes-Tr:CAB14303" /db_xref="GOA:P54560" /db_xref="InterPro:IPR001126" /db_xref="InterPro:IPR017961" /db_xref="InterPro:IPR022880" /db_xref="InterPro:IPR036775" /db_xref="SubtiList:BG11752" /db_xref="UniProtKB/Swiss-Prot:P54560" /translation="MMKEKVIFLVDMQSFYASVEKAENPHLKNRPVIVSGDPEKRGGV VLAACPLAKQKGVVNASRLWEAQEKCPEAVVLRPRMQRYIDVSLQITAILEEYTDLVE PYSIDEQFMDITGSQKLFGTPMEIAKSIQGRIMREIGVYARVGIGPNKALAKIACDNF AKKNKNGIFTLTKENMKTEMWPLPVGSMFGVGSRMKHHLNRMGISTIGGLAAFPLDLL KKKWGINGHVLWMTANGIDYSPVSTSSLDGQKAIGHGMTLPRDYEHFDKEIKVVLLEL SEEVCRRSRNAGVMGQTVSVSCRGADFDWPTGFNRQVKLAEPTNSTQDVYEAVRRLFL TFWDGKPVRRLGVNLSQLSSDDIWQLNLFQDYAKKMSLGYVMDGIKNRFGDTAIIRAA SLTAAGQAFERAAKIGGHYK*" /label="polYB CDS" gene complement(2063492..2064730) /gene="polYB" /locus_tag="BSU_23710" /old_locus_tag="BSU23710" /label="polYB gene" misc_feature 2063654..2063655 /Source="Nicolas_upshift_promotors" /id="U1854" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.005994005994006" /xcortree=20 /SigmaFactorBS="tcacatagcctaggctcattttctttgcataatcctgaaata aattgagCTgccatatgtcatcagatgagagctgagacagattgacaccgaggcggcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2063665 /Source="Nicolas_upshifts" /id="U1854" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.005994005994006" /xcortree=20 /SigmaFactorBS="tcacatagcctaggctcattttctttgcataatcctgaaata aattgagCTgccatatgtcatcagatgagagctgagacagattgacaccgaggcggcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2063720 /Source="Nicolas_upshifts" /id="D1236" /incds=1 /nref=2 /ntot=2 /MaxReadThrough="-0.14995" /MaxDrop="4.86715" /score="-1.04904304" /energy="-6.5" /TU="NA" /idTUdmin="U1854" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2064755..2064773) /Source="Nicolas_upshift_promotors" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="promotor_-10" upshifts complement(2064764) /Source="Nicolas_upshifts" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="upshifts" promotor_-35 complement(2064790..2064795) /Source="Nicolas_upshift_promotors" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="promotor_-35" promotor_-35 2064835..2064838 /Source="Nicolas_upshift_promotors" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2064853..2064872 /Source="Nicolas_upshift_promotors" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2064862 /Source="Nicolas_upshifts" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="upshifts" CDS 2064896..2065102 /gene="yqzH" /locus_tag="BSU_23720" /old_locus_tag="BSU23720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390253.1" /db_xref="EnsemblGenomes-Gn:BSU23720" /db_xref="EnsemblGenomes-Tr:CAB14304" /db_xref="InterPro:IPR025546" /db_xref="SubtiList:BG13774" /db_xref="UniProtKB/Swiss-Prot:O32014" /translation="MEKFVEKMLGQALRQYGRNVAIDPLSPYEKQSLKAALQERRNEE PDEDLHAHIEDIIYDYVTNQGLFS*" /label="yqzH CDS" gene 2064896..2065102 /gene="yqzH" /locus_tag="BSU_23720" /old_locus_tag="BSU23720" /label="yqzH gene" promotor_-35 2065585..2065588 /Source="Nicolas_upshift_promotors" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2065603..2065622 /Source="Nicolas_upshift_promotors" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2065619 /Source="Nicolas_upshifts" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="upshifts" CDS 2065651..2066883 /gene="yqjV" /locus_tag="BSU_23730" /old_locus_tag="BSU23730" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390254.2" /db_xref="EnsemblGenomes-Gn:BSU23730" /db_xref="EnsemblGenomes-Tr:CAB14305" /db_xref="GOA:P54559" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11751" /db_xref="UniProtKB/Swiss-Prot:P54559" /translation="MKKWKDIHPISWTIIIGTIFGRMATSMSIPFLAIYLTAVQGASA SYAGLVIAASSSVGILASFYGGYISDKFGRKNMMLVSIFGWMLVFAGFAAASNLWVFF VVNALNGLCKSLFEPASKALLSDMTEEKTRLLVFNLRYAAINIGVVFGPVLGLYFGSS QSTTPFLVPAVIYGLYGIVLALQFKKHPSLSAPAQSRNMSVREAFMVTQKDYLFTIAL VGITLCTFGYSQFSSTFPQYMAQNPLIGNGTKLYGLMLTLNAIVVLATQFPIVHFAKR FSPLCSLMLGNVMVSISMAIFTVSHGVPSIVMIVITFTIGEVLLFSMMDLYVDQIAKP GLKGTYFGAIGFSQLGNVIGPWVGGICIDLFGAGRPIYIFSVLSGITLLGLPFLAFAY RQMKMETTKHRSRLEKPL*" /label="yqjV CDS" gene 2065651..2066883 /gene="yqjV" /locus_tag="BSU_23730" /old_locus_tag="BSU23730" /label="yqjV gene" CDS 2066730..2067092 /gene="yqjU" /locus_tag="BSU_23740" /old_locus_tag="BSU23740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390255.2" /db_xref="EnsemblGenomes-Gn:BSU23740" /db_xref="EnsemblGenomes-Tr:CAB14306" /db_xref="GOA:P54558" /db_xref="SubtiList:BG11750" /db_xref="UniProtKB/Swiss-Prot:P54558" /translation="MYRPVWRWPADLYFFCPERHYPARPAIFSVRLSANENGDHKTPF PSGKAALNKKRKRMNLSRKHEVKNMNIGDVMFQLFVFIIFAAVVFAAVTGFKYAKNRK AQLDRIEKKLNSLSEDHD*" /label="yqjU CDS" gene 2066730..2067092 /gene="yqjU" /locus_tag="BSU_23740" /old_locus_tag="BSU23740" /label="yqjU gene" S_feature complement(2066909..2067088) /Source="Nicolas_S_feature" /locus_tag="new_2467979_2468158_c" /HighExp="Sw, BC, C90, C30, M0t90, BI, Lbtran, Lbstat, M40t45, G135" /AntisenseName="yqjU" /AntisenseCor="-0.38632421151235602" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S899" downshifts complement(2066942) /Source="Nicolas_upshifts" /id="D1237" /incds=0 /nref=59 /ntot=226 /MaxReadThrough="1.66997" /MaxDrop="4.81479" /score="21.7095422" /energy="-11.4" /TU="NA" /idTUdmin="U1858" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2067089..2067475) /gene="yqjT" /locus_tag="BSU_23750" /old_locus_tag="BSU23750" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase" /protein_id="NP_390256.1" /db_xref="EnsemblGenomes-Gn:BSU23750" /db_xref="EnsemblGenomes-Tr:CAB14307" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11749" /db_xref="UniProtKB/Swiss-Prot:P54557" /translation="MHHIELYVSDLEASRRFWGWFLKELGYKEYQKWSSGISWKKDRF YLVIVQAKEPFLEPEYHRCRVGLNHLAFHAESKLQVDQMTEKLTAKGYRVLYRDRHPF AGGDGHYAVFCEDPDRIKVELVAPSC*" /label="yqjT CDS" gene complement(2067089..2067475) /gene="yqjT" /locus_tag="BSU_23750" /old_locus_tag="BSU23750" /label="yqjT gene" CDS complement(2067479..2068438) /gene="coaA" /locus_tag="BSU_23760" /old_locus_tag="BSU23760" /EC_number="2.7.1.33" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1328157, 24784177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1328157, 24784177; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate kinase" /protein_id="NP_390257.2" /db_xref="EnsemblGenomes-Gn:BSU23760" /db_xref="EnsemblGenomes-Tr:CAB14308" /db_xref="GOA:P54556" /db_xref="InterPro:IPR004566" /db_xref="InterPro:IPR006083" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11748" /db_xref="UniProtKB/Swiss-Prot:P54556" /translation="MKNKELNLHTLYTQHNRESWSGFGGHLSIAVSEEEAKAVEGLND YLSVEEVETIYIPLVRLLHLHVKSAAERNKHVNVFLKHPHSAKIPFIIGIAGSVAVGK STTARILQKLLSRLPDRPKVSLITTDGFLFPTAELKKKNMMSRKGFPESYDVKALLEF LNDLKSGKDSVKAPVYSHLTYDREEGVFEVVEQADIVIIEGINVLQSPTLEDDRENPR IFVSDFFDFSIYVDAEESRIFTWYLERFRLLRETAFQNPDSYFHKFKDLSDQEADEMA ASIWESVNRPNLYENILPTKFRSDLILRKGDGHKVEEVLVRRV*" /label="coaA CDS" gene complement(2067479..2068438) /gene="coaA" /locus_tag="BSU_23760" /old_locus_tag="BSU23760" /label="coaA gene" S_feature complement(2068439..2068509) /Source="Nicolas_S_feature" /locus_tag="new_2469509_2469579_c" /HighExp="LBGtran, dia15, Diami, C90, H2O2, M0t45, G135, Lbtran, HiTm, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S900" CDS complement(2068510..2069856) /gene="dsdA" /locus_tag="BSU_23770" /old_locus_tag="BSU23770" /EC_number="4.3.1.18" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592420; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-serine ammonia-lyase" /protein_id="NP_390258.2" /db_xref="EnsemblGenomes-Gn:BSU23770" /db_xref="EnsemblGenomes-Tr:CAB14309" /db_xref="GOA:P54555" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR011780" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG11747" /db_xref="UniProtKB/Swiss-Prot:P54555" /translation="MSVHSEVLHALLKDPFIQKLIDAEPVFWANSGKKEGPLPRADEW ATEIAEAEKRMQRFAPYIAEVFPETKGAKGIIESPLFEVQHMKGKLEAAYQQPFPGRW LLKCDHELPISGSIKARGGIYEVLKYAENLALQEGMLQETDDYRILQEERFTGFFSRY SIAVGSTGNLGLSIGIIGAALGFRVTVHMSADAKQWKKDLLRQKGVTVMEYETDYSEA VNEGRRQAEQDPFCYFIDDEHSRQLFLGYAVAASRLKTQLDCMNIKPSLETPLFVYLP CGVGGGPGGVAFGLKLLYGDDVHVFFAEPTHSPCMLLGLYSGLHEKISVQDIGLDNQT AADGLAVGRPSGFVGKLIEPLLSGCYTVEDNTLYTLLHMLAVSEDKYLEPSALAGMFG PVQLFSTEEGRRYAQKYKMEHAVHVVWGTGGSMVPKDEMAAYNRIGADLLKKRNEK*" /label="dsdA CDS" gene complement(2068510..2069856) /gene="dsdA" /locus_tag="BSU_23770" /old_locus_tag="BSU23770" /label="dsdA gene" S_feature complement(2069857..2069931) /Source="Nicolas_S_feature" /locus_tag="new_2470927_2471001_c" /HighExp="C90, LBGtran, Diami, dia15, H2O2, dia5, G150, MG 15, GM-0.2, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S901" CDS complement(2069932..2070711) /gene="yqjQ" /locus_tag="BSU_23780" /old_locus_tag="BSU23780" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metabolite dehydrogenase, NAD-binding" /protein_id="NP_390259.1" /db_xref="EnsemblGenomes-Gn:BSU23780" /db_xref="EnsemblGenomes-Tr:CAB14310" /db_xref="GOA:P54554" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11746" /db_xref="UniProtKB/Swiss-Prot:P54554" /translation="MKHIAGKRIWITGASGGLGERIAYLCAAEGAHVLLSARREDRLI EIKRKITEEWSGQCEIFPLDVGRLEDIARVRDQIGSIDVLINNAGFGIFETVLDSTLD DMKAMFDVNVFGLIACTKAVLPQMLEQKKGHIINIASQAGKIATPKSSLYSATKHAVL GYSNALRMELSGTGIYVTTVNPGPIQTDFFSIADKGGDYAKNVGRWMLDPDDVAAQIT AAIFTKKREINLPRLMNAGTKLYQLFPALVEKLAGRALMKK*" /label="yqjQ CDS" gene complement(2069932..2070711) /gene="yqjQ" /locus_tag="BSU_23780" /old_locus_tag="BSU23780" /label="yqjQ gene" CDS complement(2070717..2071676) /gene="yqjP" /locus_tag="BSU_23790" /old_locus_tag="BSU23790" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_390260.1" /db_xref="EnsemblGenomes-Gn:BSU23790" /db_xref="EnsemblGenomes-Tr:CAB14311" /db_xref="GOA:P54553" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11745" /db_xref="UniProtKB/Swiss-Prot:P54553" /translation="MTTEDVIAIRVPTPFAVGDVIVYLVKGDALTLIDAGPNTKEAAR ALQEQLAAVNVKLSDIEQVVLTHHHADHAGLLDVFSDEIEVIGHTFNEPYISQNQAFM DWQKRFFQKLLPELGVPFDTGKAEKLIRSAYAFSCTRSLTKSIREGMGIDGLEGWSVL EMPGHAESHIVLFHEKSGRMLGGDLLLANSSSNPILEAPKAGDVRSKPLVDYQRSLRR LSQLDPTIVFPGHGEPITSVQALIEKRFDKQRNRTEDVRRMLDEKPMTAFQVCQQLFP AVYEKELFLTMSETAGHLDVLEAEEAITSYWEGNTVYFKTMKR*" /label="yqjP CDS" gene complement(2070717..2071676) /gene="yqjP" /locus_tag="BSU_23790" /old_locus_tag="BSU23790" /label="yqjP gene" promotor_-10 complement(2071698..2071717) /Source="Nicolas_upshift_promotors" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2071717) /Source="Nicolas_upshifts" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2071732..2071739) /Source="Nicolas_upshift_promotors" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2071773..2071780 /Source="Nicolas_upshift_promotors" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2071794..2072080 /Source="Nicolas_S_feature" /locus_tag="new_2472864_2473150" /HighExp="Diami, C90, BC, Paraq, G180, GM 15, Oxctl, S7, MG-0.2, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S902" upshifts 2071794 /Source="Nicolas_upshifts" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2071796..2071815 /Source="Nicolas_upshift_promotors" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 2071810..2072055 /gene="pswI" /locus_tag="BSU_misc_RNA_91" /product="proline T-box riboswitch" /experiment="publication(s) with functional evidences, PMID:21233158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21233158" /label="pswI RNA" gene 2071810..2072055 /gene="pswI" /locus_tag="BSU_misc_RNA_91" /label="pswI gene" CDS 2072081..2072917 /gene="proI" /locus_tag="BSU_23800" /old_locus_tag="BSU23800" /EC_number="1.5.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 21233158, 28752945, 28824574" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 21233158, 28752945, 28824574; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrroline-5-carboxylate reductase (NADP-dependent, weak activity)" /protein_id="NP_390261.1" /db_xref="EnsemblGenomes-Gn:BSU23800" /db_xref="EnsemblGenomes-Tr:CAB14312" /db_xref="GOA:P54552" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11744" /db_xref="UniProtKB/Swiss-Prot:P54552" /translation="MKKIGFVGAGSMAEAMINGILQSGITKPEHIYITNRSNDERLIE LKETYSVRPCRDKNEFFTHTDIIILAFKPKDAAESIDSIRPYIKDQLVISVLAGLTIE TIQHYFGRKLAVIRVMPNTSAAIRKSATGFSVSTEASKNDIIAAKALLETIGDATLVE ERHLDAVTAIAGSGPAYVYRYIEAMEKAAQKVGLDKETAKALILQTMAGATDMLLQSG KQPEKLRKEITSPGGTTEAGLRALQDSRFEEAIIHCIEETAKRSAEIKEQFAGAALER HS*" /label="proI CDS" gene 2072081..2072917 /gene="proI" /locus_tag="BSU_23800" /old_locus_tag="BSU23800" /label="proI gene" downshifts 2072915 /Source="Nicolas_upshifts" /id="D1238" /incds=0 /nref=29 /ntot=190 /MaxReadThrough="0.55696" /MaxDrop="3.78131" /score="36.2472665" /energy="-12" /TU="NA" /idTUdmin="U1859" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2072958..2074601) /gene="yqjN" /locus_tag="BSU_23810" /old_locus_tag="BSU23810" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-deacylase" /protein_id="NP_390262.2" /db_xref="EnsemblGenomes-Gn:BSU23810" /db_xref="EnsemblGenomes-Tr:CAB14313" /db_xref="GOA:P54551" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR012166" /db_xref="SubtiList:BG11743" /db_xref="UniProtKB/Swiss-Prot:P54551" /translation="MNWQTKDELLALLTSLVQYESITGSKGEVALAEYLYFILKDKPY FQKHPDDVTLHPMDDGRSFLTALVKKKNVKKTVLLLSHFDVVDIEDYGEFKHMACKPA ELLSSFLEKKELLPERVRRDAESGDWLFGRGTMDMKAGLCIQLSMLERAMNGHFEGNL LLITVPDEEVNSRGMIEAVPALKEMEKKHDITLTACLNAEPMFEKFPGDQQQYFYTGS IGKVLAGFFCKGIETHVGEPFSGLNANLMVSEINRLLELNADYCEKVDGEVTPPPVNL MQKDLKEAYSVQTPHTAVTLFNVLSMKRSASELHQMLLKTAEQAAEEIMSNVRKKTQD FQQFEPFQPIERDVTVLTFDELVSRAKKRAGISETERALNYAFANRGELGDRDFSTKI VSELASLCKEDAPLIVLFYSPPLYPAVSSKDDQLIRNTADQIKHYAAERYGIALREVQ YFPGLSDLSYLQLEKQEVDAYTSNMPLFNRGYSLPSGKNQALYVPVLNVGPAGKDPHK WTERLYMPYSFEVLPDLLSFTISALLKQSESAGQLLREK*" /label="yqjN CDS" gene complement(2072958..2074601) /gene="yqjN" /locus_tag="BSU_23810" /old_locus_tag="BSU23810" /label="yqjN gene" downshifts complement(2072970) /Source="Nicolas_upshifts" /id="D1239" /incds=0 /nref=1 /ntot=62 /MaxReadThrough="2.2598" /MaxDrop="2.55609" /score="14.9380989" /energy="-12" /TU="NA" /idTUdmin="U1861" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2074619..2074625 /Source="Nicolas_upshift_promotors" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2074632 /Source="Nicolas_upshifts" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2074639..2074650 /Source="Nicolas_upshift_promotors" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(2074657..2074676) /Source="Nicolas_upshift_promotors" /id="U1861" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=397 /SigmaFactorBS="ctttcccgtcatataaactgctcaaatgaaccgcttttgtca aacaTTTCTGTATAATAGACGAGAaatcagtttatttttcagtatagaagcattttta t" /listShort="yqjN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2074662) /Source="Nicolas_upshifts" /id="U1861" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=397 /SigmaFactorBS="ctttcccgtcatataaactgctcaaatgaaccgcttttgtca aacaTTTCTGTATAATAGACGAGAaatcagtttatttttcagtatagaagcattttta t" /listShort="yqjN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2074708..2074715 /Source="Nicolas_upshift_promotors" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2074729..2074748 /Source="Nicolas_upshift_promotors" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2074731 /Source="Nicolas_upshifts" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="upshifts" CDS 2074773..2075789 /gene="yqjM" /locus_tag="BSU_23820" /old_locus_tag="BSU23820" /EC_number="1.6.99.1" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12660247, 15249051, 15890652, 20011599, 20461254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12660247, 15249051, 15890652, 20011599, 20461254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent flavin oxidoreductase (acting oncinnamaldehyde-related compounds)" /protein_id="NP_390263.1" /db_xref="EnsemblGenomes-Gn:BSU23820" /db_xref="EnsemblGenomes-Tr:CAB14314" /db_xref="GOA:P54550" /db_xref="InterPro:IPR001155" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023663" /db_xref="PDB:1Z41" /db_xref="PDB:1Z42" /db_xref="PDB:1Z44" /db_xref="PDB:1Z48" /db_xref="SubtiList:BG11742" /db_xref="UniProtKB/Swiss-Prot:P54550" /translation="MARKLFTPITIKDMTLKNRIVMSPMCMYSSHEKDGKLTPFHMAH YISRAIGQVGLIIVEASAVNPQGRITDQDLGIWSDEHIEGFAKLTEQVKEQGSKIGIQ LAHAGRKAELEGDIFAPSAIAFDEQSATPVEMSAEKVKETVQEFKQAAARAKEAGFDV IEIHAAHGYLIHEFLSPLSNHRTDEYGGSPENRYRFLREIIDEVKQVWDGPLFVRVSA SDYTDKGLDIADHIGFAKWMKEQGVDLIDCSSGALVHADINVFPGYQVSFAEKIREQA DMATGAVGMITDGSMAEEILQNGRADLIFIGRELLRDPFFARTAAKQLNTEIPAPVQY ERGW*" /label="yqjM CDS" gene 2074773..2075789 /gene="yqjM" /locus_tag="BSU_23820" /old_locus_tag="BSU23820" /label="yqjM gene" downshifts 2075776 /Source="Nicolas_upshifts" /id="D1240" /incds=0 /nref=42 /ntot=157 /MaxReadThrough="2.79686" /MaxDrop="5.04803" /score="39.119339" /energy="-12.8" /TU="U1862" /idTUdmin="U1862" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-35 2075838..2075847 /Source="Nicolas_upshift_promotors" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2075860..2075875 /Source="Nicolas_upshift_promotors" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2075864 /Source="Nicolas_upshifts" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="upshifts" CDS 2075899..2076660 /gene="yqjL" /locus_tag="BSU_23830" /old_locus_tag="BSU23830" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15838020, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390264.1" /db_xref="EnsemblGenomes-Gn:BSU23830" /db_xref="EnsemblGenomes-Tr:CAB14315" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11741" /db_xref="UniProtKB/Swiss-Prot:P54549" /translation="MKSAWMEKTYTIDGCAFHTQHRKGSSGVTIVFEAGYGTSSETWK PLMADIDDEFGIFTYDRAGIGKSGQSRAKRTADQQVKELESLLKAADVKPPYLAVSHS YGAVITGLWACKNKHDIIGMVLLDPALGDCASFTFIPEEMHKSHTRKMMLEGTHAEFS KSLQELKKRQVHLGNMPLLVLSSGERTEKFAAEQEWQNLHSSILSLSNQSGWIQAKNS SHNIHHDEPHIVHLAIYDVWCAACQQAAPLYQAVN*" /label="yqjL CDS" gene 2075899..2076660 /gene="yqjL" /locus_tag="BSU_23830" /old_locus_tag="BSU23830" /label="yqjL gene" downshifts 2076568 /Source="Nicolas_upshifts" /id="D1241" /incds=1 /nref=21 /ntot=204 /MaxReadThrough="3.34804" /MaxDrop="3.21955" /score="0.451826768" /energy="-11.2" /TU="U1863" /idTUdmin="U1862" /TUdmin=22 /isTUend="TRUE" /label="downshifts" downshifts 2076656 /Source="Nicolas_upshifts" /id="D1242" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="1.34151" /MaxDrop="3.85711" /score="0.451826768" /energy="-11.2" /TU="NA" /idTUdmin="U1863" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2076688..2076888) /Source="Nicolas_S_feature" /locus_tag="new_2477758_2477958_c" /HighExp="B60, S5, Etha, S4, B36, BMM, Heat, S3, S2, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.21631400000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S903" CDS complement(2076704..2076829) /gene="rpmGCc" /locus_tag="BSU_23836" /old_locus_tag="BSU23836" /function="10.2: Ribosomal proteins: synthesis and modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 27561249; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="ribosomal protein L33* pseudogene" /translation="CTETGDRNYITTKNKRTNPDRLELKKYSPRLKKYTLHRETK*" /label="rpmGCc CDS" gene complement(2076704..2076829) /gene="rpmGCc" /locus_tag="BSU_23836" /old_locus_tag="BSU23836" /pseudo /label="rpmGCc gene" downshifts complement(2076731) /Source="Nicolas_upshifts" /id="D1243" /incds=0 /nref=187 /ntot=264 /MaxReadThrough="3.91531" /MaxDrop="7.65732" /score="5.23287853" /energy="-8.8" /TU="U1864" /idTUdmin="U1865" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2076822..2076854) /gene="rpmGCn" /locus_tag="BSU_23837" /old_locus_tag="BSU23837" /function="10.2: Ribosomal proteins: synthesis and modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 19648245, 27561249; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="ribosomal protein L33C pseudogene" /db_xref="PSEUDO:CCQ48601.1" /translation="MRVNVTLALH*" /label="rpmGCn CDS" gene complement(2076822..2076854) /gene="rpmGCn" /locus_tag="BSU_23837" /old_locus_tag="BSU23837" /pseudo /label="rpmGCn gene" promotor_-10 complement(2076882..2076901) /Source="Nicolas_upshift_promotors" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2076888) /Source="Nicolas_upshifts" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2076914..2076921) /Source="Nicolas_upshift_promotors" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2076936..2077859) /gene="rnz" /locus_tag="BSU_23840" /old_locus_tag="BSU23840" /EC_number="3.1.26.11" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 12941704, 16336119, 17005971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12941704, 16336119, 17005971; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease Z" /protein_id="NP_390265.1" /db_xref="EnsemblGenomes-Gn:BSU23840" /db_xref="EnsemblGenomes-Tr:CAB14316" /db_xref="GOA:P54548" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR013471" /db_xref="InterPro:IPR036866" /db_xref="PDB:1Y44" /db_xref="PDB:2FK6" /db_xref="PDB:4GCW" /db_xref="SubtiList:BG11740" /db_xref="UniProtKB/Swiss-Prot:P54548" /translation="MELLFLGTGAGIPAKARNVTSVALKLLEERRSVWLFDCGEATQH QILHTTIKPRKIEKIFITHMHGDHVYGLPGLLGSRSFQGGEDELTVYGPKGIKAFIET SLAVTKTHLTYPLAIQEIEEGIVFEDDQFIVTAVSVIHGVEAFGYRVQEKDVPGSLKA DVLKEMNIPPGPVYQKIKKGETVTLEDGRIINGNDFLEPPKKGRSVVFSGDTRVSDKL KELARDCDVLVHEATFAKEDRKLAYDYYHSTTEQAAVTAKEARAKQLILTHISARYQG DASLELQKEAVDVFPNSVAAYDFLEVNVPRG*" /label="rnz CDS" gene complement(2076936..2077859) /gene="rnz" /locus_tag="BSU_23840" /old_locus_tag="BSU23840" /label="rnz gene" promotor_-10 complement(2077885..2077904) /Source="Nicolas_upshift_promotors" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2077898) /Source="Nicolas_upshifts" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2077918..2077923) /Source="Nicolas_upshift_promotors" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2077997..2078004 /Source="Nicolas_upshift_promotors" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2078018..2078037 /Source="Nicolas_upshift_promotors" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2078020..2078085 /Source="Nicolas_S_feature" /locus_tag="new_2479090_2479155" /HighExp="dia5, C90, MG 5, Lbexp, MG t5, MG 45, M9-exp, GM 90, GM 120, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S904" upshifts 2078020 /Source="Nicolas_upshifts" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="upshifts" CDS 2078086..2079555 /gene="zwf" /locus_tag="BSU_23850" /old_locus_tag="BSU23850" /EC_number="1.1.1.49" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1704005, 19779711, 26129872" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1704005, 19779711, 26129872; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-6-phosphate 1-dehydrogenase (NADP-dependent)" /protein_id="NP_390266.2" /db_xref="EnsemblGenomes-Gn:BSU23850" /db_xref="EnsemblGenomes-Tr:CAB14317" /db_xref="GOA:P54547" /db_xref="InterPro:IPR001282" /db_xref="InterPro:IPR019796" /db_xref="InterPro:IPR022674" /db_xref="InterPro:IPR022675" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11739" /db_xref="UniProtKB/Swiss-Prot:P54547" /translation="MKTNQQPKAVIVIFGATGDLAKRKLYPSIHRLYQNGQIGEEFAV VGVGRRPWSNEDLRQTVKTSISSSADKHIDDFTSHFYYHPFDVTNPGSYQELNVLLNQ LEDTYQIPNNRMFYLAMAPEFFGTIAKTLKSEGVTATTGWSRLVIEKPFGHDLPSAQA LNKEIREAFTEDQIYRIDHYLGKQMVQNIEVIRFANAIFEPLWTNRYISNIQITSSES LGVEDRARYYEKSGALRDMVQNHIMQMVALLAMEPPIKLNTEEIRSEKVKVLRALRPI AKDEVDEYFVRGQYHAGEIDGVPVPAYTDEDNVAPDSNTETFVAGKLLIDNFRWAGVP FYIRTGKRMKEKSTKIVVQFKDIPMNLYYGNENNMNPNLLVIHIQPDEGITLYLNAKK LGGAAHAQPIKLDYCSNCNDELNTPEAYEKLIHDCLLGDATNFAHWDEVALSWSFVDS ISETWAANKTLSPNYESGSMGPKESDDLLVKDGLHWWNI*" /label="zwf CDS" gene 2078086..2079555 /gene="zwf" /locus_tag="BSU_23850" /old_locus_tag="BSU23850" /label="zwf gene" downshifts 2079538 /Source="Nicolas_upshifts" /id="D1244" /incds=0 /nref=206 /ntot=286 /MaxReadThrough="3.46838" /MaxDrop="7.76173" /score="1.1363172" /energy="-15.2" /TU="U1866" /idTUdmin="U1866" /TUdmin="-90" /isTUend="FALSE" /label="downshifts" terminator 2079563..2079602 /created_by="User" /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" /label="Delta6_zwf-T-gndA_Terminator" Polymorphism join(2079575,2079578) /Source="geneious" /ID="SNP_BsDelta6_2480646_2480647" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=2 /Amino_Acid_Change /CDS_Position /Change="TA -> AT" /Codon_Change /Coverage=115 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="TA" /Variant_Nucleotides="AT" /Variant_P_Value=0 /Variant_Raw_Frequency=113 /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" Polymorphism join(2079583,2079584) /Source="geneious" /ID="SNP_BsDelta6_2480654_2480654" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="-T" /Codon_Change /Coverage=115 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides /Variant_P_Value="2.1e-279" /Variant_Raw_Frequency=113 /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" Polymorphism join(2079595,2079596) /Source="geneious" /ID="SNP_BsDelta6_2480667_2480667" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="-T" /Codon_Change /Coverage=116 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides /Variant_P_Value="2.9e-244" /Variant_Raw_Frequency=110 /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" downshifts 2079604 /Source="Nicolas_upshifts" /id="D1245" /incds=0 /nref=1 /ntot=104 /MaxReadThrough="2.5392" /MaxDrop="4.74183" /score="1.1363172" /energy="-15.2" /TU="U1866" /idTUdmin="U1866" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2079678..2081087) /gene="gndA" /locus_tag="BSU_23860" /old_locus_tag="BSU23860" /EC_number="1.1.1.44" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15231785, 15755726" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231785, 15755726; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADP+-dependent 6-P-gluconate dehydrogenase" /protein_id="NP_390267.2" /db_xref="EnsemblGenomes-Gn:BSU23860" /db_xref="EnsemblGenomes-Tr:CAB14318" /db_xref="GOA:P80859" /db_xref="InterPro:IPR006113" /db_xref="InterPro:IPR006114" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR006183" /db_xref="InterPro:IPR006184" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11738" /db_xref="UniProtKB/Swiss-Prot:P80859" /translation="MSKQQIGVIGLAVMGKNLALNIESRGFSVSVYNRSSSKTEEFLQ EAKGKNVVGTYSIEEFVQSLETPRKILLMVKAGTATDATIQSLLPHLEKDDILIDGGN TYYKDTQRRNKELAESGIHFIGTGVSGGEEGALKGPSIMPGGQKEAHELVKPILEAIS AKVDGEPCTTYIGPDGAGHYVKMVHNGIEYGDMQLISESYFILKQVLGLSADELHEVF AEWNKGELDSYLIEITADIFTKKDEETGKPLVDVILDKAGQKGTGKWTSQSALDLGVP LPIITESVFARFISAMKEERVKASGLLSGPEVKPVTENKEELIEAVRKALFMSKICSY AQGFAQMKAASEEYNWDLKYGEIAMIFRGGCIIRAAFLQKIKEAYDREPELDNLLLDS YFKNIVESYQGALRQVISLAVAQGVPVPSFSSALAYYDSYRTAVLPANLIQAQRDYFG AHTYERTDKEGIFHTEWMK*" /label="gndA CDS" gene complement(2079678..2081087) /gene="gndA" /locus_tag="BSU_23860" /old_locus_tag="BSU23860" /label="gndA gene" downshifts complement(2079695) /Source="Nicolas_upshifts" /id="D1246" /incds=0 /nref=220 /ntot=361 /MaxReadThrough="1.88983" /MaxDrop="8.82894" /score="24.3727084" /energy="-18" /TU="NA" /idTUdmin="U1867" /TUdmin="-15" /isTUend="TRUE" /label="downshifts" downshifts complement(2079768) /Source="Nicolas_upshifts" /id="D1247" /incds=1 /nref=1 /ntot=36 /MaxReadThrough="8.40595" /MaxDrop="2.3555" /score="24.3727084" /energy="-18" /TU="U1867" /idTUdmin="U1867" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" misc_feature complement(2081151..2081169) /Source="Nicolas_upshift_promotors" /id="U1867" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.987012987012987" /xcortree=2358 /SigmaFactorBS="atgaaaagaaaagctgaatcgcttgaaaaaaagggtgaatgt atGGTAATTTCTTTATTATAAatatcattttattttaatttaaattttaaaatgatta a" /listShort="gndA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2081153) /Source="Nicolas_upshifts" /id="U1867" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.987012987012987" /xcortree=2358 /SigmaFactorBS="atgaaaagaaaagctgaatcgcttgaaaaaaagggtgaatgt atGGTAATTTCTTTATTATAAatatcattttattttaatttaaattttaaaatgatta a" /listShort="gndA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2081197..2082441) /gene="polYA" /locus_tag="BSU_23870" /old_locus_tag="BSU23870" /EC_number="2.7.7.7" /function="16.6: Maintain" /function="16.5: Explore" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12137951, 12644484, 15469515, 16045613, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12137951, 12644484, 15469515, 16045613, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-damage lesion bypass DNA polymerase" /protein_id="NP_390268.2" /db_xref="EnsemblGenomes-Gn:BSU23870" /db_xref="EnsemblGenomes-Tr:CAB14319" /db_xref="GOA:P54545" /db_xref="InterPro:IPR001126" /db_xref="InterPro:IPR017061" /db_xref="InterPro:IPR017961" /db_xref="InterPro:IPR022880" /db_xref="InterPro:IPR024728" /db_xref="InterPro:IPR036775" /db_xref="SubtiList:BG11737" /db_xref="UniProtKB/Swiss-Prot:P54545" /translation="MPGKSRIIFHIDMNSFYASVEMAYDPALRGKPVAVAGNVKERKG IVVTCSYEARARGVKTTMPVWQAKRHCPELIVLPPNFDRYRNSSRAMFTILREYTDLV EPVSIDEGYMDMTDTPYSSRALETAKEIQSRLQKELLLPSSIGIAPNKFLAKMASDMK KPLGITILRKRQVPDILWPLPVGEMHGVGKKTAEKLKGLGIHTIGELAAADEHSLKRL LGINGPRLKNKANGIHHAPVDPERIYEFKSVGNSSTLSHDSSDEEELLGVFRKLAASV SDRLQRKEVMASKLFIMIRYADWRTITRSTTLRNPIDQKNDILKEAEHLFFKHWNKNP VRLLGITGTDLVEKEQAYKQLDLFSFNEDAKDEPIQQMMEKLNKKYGTKLIRKGATLK KEESKTKGTSFNKDFFQDEKKS*" /label="polYA CDS" gene complement(2081197..2082441) /gene="polYA" /locus_tag="BSU_23870" /old_locus_tag="BSU23870" /label="polYA gene" S_feature complement(2082442..2082716) /Source="Nicolas_S_feature" /locus_tag="new_2483514_2483788_c" /HighExp="M40t90, Sw, M40t45, H2O2, C30, Cold, Etha, C90, Diami, BC" /AntisenseName="yqzJ" /AntisenseCor="0.48883700687558601" /AntisenseRegPval="-16.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S905" promotor_-35 2082462..2082469 /Source="Nicolas_upshift_promotors" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2082483..2082502 /Source="Nicolas_upshift_promotors" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2082483 /Source="Nicolas_upshifts" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="upshifts" CDS 2082514..2082801 /gene="mifM" /locus_tag="BSU_23880" /old_locus_tag="BSU23880" /experiment="publication(s) with functional evidences, PMID:19779460, 21383133, 22720735, 25313395, 25903689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19779460, 21383133, 22720735, 25313395, 25903689; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of OxaAB translation" /protein_id="YP_054586.1" /db_xref="EnsemblGenomes-Gn:BSU23880" /db_xref="EnsemblGenomes-Tr:CAE01460" /db_xref="GOA:Q7WY64" /db_xref="PDB:3J9W" /db_xref="SubtiList:BG14191" /db_xref="UniProtKB/Swiss-Prot:Q7WY64" /translation="MTMFVESINDVLFLVDFFTIILPALTAIGIAFLLRECRAGEQWK SKRTDEHQTVFHINRTDFLIIIYHRITTWIRKVFRMNSPVNDEEDAGSLLL*" /label="mifM CDS" gene 2082514..2082801 /gene="mifM" /locus_tag="BSU_23880" /old_locus_tag="BSU23880" /label="mifM gene" promotor_-10 complement(2082698..2082717) /Source="Nicolas_upshift_promotors" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="promotor_-10" upshifts complement(2082718) /Source="Nicolas_upshifts" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="upshifts" promotor_-35 complement(2082733..2082736) /Source="Nicolas_upshift_promotors" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="promotor_-35" CDS 2082832..2083659 /gene="oxaAB" /locus_tag="BSU_23890" /old_locus_tag="BSU23890" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11889108, 15654078, 15671040, 15849754, 16293689, 16850406, 21204254, 24443530, 24739968, 25903689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11889108, 15654078, 15671040, 15849754, 16293689, 16850406, 21204254, 24443530, 24739968, 25903689; Product type f: factor" /codon_start=1 /transl_table=11 /product="Sec-independent factor for membrane protein insertion (YidC/SpoIIIJ family)" /protein_id="NP_390269.1" /db_xref="EnsemblGenomes-Gn:BSU23890" /db_xref="EnsemblGenomes-Tr:CAB14320" /db_xref="GOA:P54544" /db_xref="InterPro:IPR001708" /db_xref="InterPro:IPR023060" /db_xref="InterPro:IPR028055" /db_xref="SubtiList:BG11736" /db_xref="UniProtKB/Swiss-Prot:P54544" /translation="MLKTYQKLLAMGIFLIVLCSGNAAFAATNQVGGLSNVGFFHDYL IEPFSALLKGVAGLFHGEYGLSIILVTIIVRIVVLPLFVNQFKKQRIFQEKMAVIKPQ VDSIQVKLKKTKDPEKQKELQMEMMKLYQEHNINPLAMGCLPMLIQSPIMIGLYYAIR STPEIASHSFLWFSLGQSDILMSLSAGIMYFVQAYIAQKLSAKYSAVPQNPAAQQSAK LMVFIFPVMMTIFSLNVPAALPLYWFTSGLFLTVQNIVLQMTHHKSKKTAALTESVK* " /label="oxaAB CDS" gene 2082832..2083659 /gene="oxaAB" /locus_tag="BSU_23890" /old_locus_tag="BSU23890" /label="oxaAB gene" downshifts 2083476 /Source="Nicolas_upshifts" /id="D1248" /incds=1 /nref=4 /ntot=125 /MaxReadThrough="5.05074" /MaxDrop="3.49092" /score="-5.67811369" /energy="-7.6" /TU="U1868" /idTUdmin="U1868" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts 2083652 /Source="Nicolas_upshifts" /id="D1249" /incds=0 /nref=71 /ntot=229 /MaxReadThrough="1.09826" /MaxDrop="6.56698" /score="-5.67811369" /energy="-7.6" /TU="NA" /idTUdmin="U1868" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2083664..2084584) /Source="Nicolas_S_feature" /locus_tag="new_2484736_2485656_c" /HighExp="LoTm, B36, M0t90, M40t90, Lbstat, M9-stat, T1.30H, B60, LBGtran, BT" /AntisenseName="yqjF" /AntisenseCor="0.18628881890353799" /AntisenseRegPval="-2.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S906" downshifts complement(2083707) /Source="Nicolas_upshifts" /id="D1250" /incds=0 /nref=170 /ntot=248 /MaxReadThrough="0.24428" /MaxDrop="6.31082" /score="18.1943524" /energy="-12.4" /TU="NA" /idTUdmin="U1871" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2083777..2083783 /Source="Nicolas_upshift_promotors" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2083797..2083815 /Source="Nicolas_upshift_promotors" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2083806 /Source="Nicolas_upshifts" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="upshifts" CDS 2083839..2084567 /gene="yqjF" /locus_tag="BSU_23900" /old_locus_tag="BSU23900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390270.3" /db_xref="EnsemblGenomes-Gn:BSU23900" /db_xref="EnsemblGenomes-Tr:CAB14321" /db_xref="InterPro:IPR018644" /db_xref="InterPro:IPR023375" /db_xref="SubtiList:BG11735" /db_xref="UniProtKB/Swiss-Prot:P54543" /translation="MTERFQQKNISVPDGIWIMRQTWNDVLFAHWPVDVSILRALVPS VLELDTYNGQAWISMLPFMLTNLRARYLPVIPGARAFPELNLRTYVTYKGKPGIYFFS LDADHRLAVLGARTFFHLPYFYADMKSEKNGDAIDYVSKRKNDKEAAFHAAYRPISAP FTAEKDSLDYWLTERYRLYTTYRNKLYYEDIHHHPWLLQNAEAEISVNTVTDAHGITL PESDPLLHYAKKQDVLFWPLRKWS*" /label="yqjF CDS" gene 2083839..2084567 /gene="yqjF" /locus_tag="BSU_23900" /old_locus_tag="BSU23900" /label="yqjF gene" CDS complement(2084608..2085723) /gene="yqjE" /locus_tag="BSU_23910" /old_locus_tag="BSU23910" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peptidase or deacylase" /protein_id="NP_390271.2" /db_xref="EnsemblGenomes-Gn:BSU23910" /db_xref="EnsemblGenomes-Tr:CAB14322" /db_xref="GOA:P54542" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR010162" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11734" /db_xref="UniProtKB/Swiss-Prot:P54542" /translation="MVNEKRLLEEFLELVQIDSETKHEAEICKVLKRKFSDLGVDVKE DDTMDITGHGAGNLICTLKGTKQTDTIYFTSHMDTVVPGNGVKPVVENGYVKTDGTTI LGADDKAGLAAMFEAIKVLKEENIEHGTIEFIITVGEESGLIGAKALDRSMITASYGY ALDSDGKVGNIIVAAPTQAKVRAAIFGKTAHAGVEPEKGISAITIASKAISKMPLGRI DEETTANIGRFEGGTQTNIVCDEVHILAEARSLVPEKMEAQVQKMKAAFEEAAADMGG RAEVEIEVMYPGFKYQDGDQVVEIAKKAAAKIGRPSELQTSGGGSDANVIAGHGIPTV NLAVGYEQIHTKNEKMPIEELVKTAEMVVAIIEEAAK*" /label="yqjE CDS" gene complement(2084608..2085723) /gene="yqjE" /locus_tag="BSU_23910" /old_locus_tag="BSU23910" /label="yqjE gene" downshifts complement(2084629) /Source="Nicolas_upshifts" /id="D1251" /incds=0 /nref=23 /ntot=203 /MaxReadThrough="3.90071" /MaxDrop="3.95711" /score="11.6635037" /energy="-10.6" /TU="U1871" /idTUdmin="U1871" /TUdmin="-923" /isTUend="FALSE" /label="downshifts" CDS complement(2085741..2087264) /gene="yqjD" /locus_tag="BSU_23920" /old_locus_tag="BSU23920" /EC_number="6.4.1.3" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative propionyl-CoA carboxylase beta chain" /protein_id="NP_390272.2" /db_xref="EnsemblGenomes-Gn:BSU23920" /db_xref="EnsemblGenomes-Tr:CAB14323" /db_xref="GOA:P54541" /db_xref="InterPro:IPR000438" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG11733" /db_xref="UniProtKB/Swiss-Prot:P54541" /translation="MNEHMDHFYTKRKQAEEGGGREKLAQQRQKGKLTARERIIFLLD QDSFIELHPFMESQVLTREQRMLGDGVVTGYGTIDGRSVYVFAQDFTVYGGALGETHA RKICALMDLAAKNKAPIIGLNDSGGARIQEGVLSLDGYGHIFYRNVLYSGVIPQISVI LGPCAGGAVYSPALTDFIFMAEQTGRMFITGPKVIEKVTGEQVDAESLGGAGIHNAVS GNAHFSGHTEKEVLTGVRKLLSYLPLNGRTTEPKPEKEASRPLLNRLVPADTTKPYDV RKVIRELADPQSFFEIQPFFAKNIVIGFARLGEKAIGIVASQPKHLAGSLTIDAADKA ARFIRFCDAFDIPLLTVEDVPGFLPGIQQEHNGIIRHGAKLLFAYAEATVPKVTLIIR KAYGGAYVAMNSKAIGADLVFAWPNAEIAVMGPEGAASILYEKEIKASADPQKTKREK TAEYKKQNAGPYKAAACGMVDDIILPEESRGRLIQAFHMLTHKTEERPKKKHGNIPL* " /label="yqjD CDS" gene complement(2085741..2087264) /gene="yqjD" /locus_tag="BSU_23920" /old_locus_tag="BSU23920" /label="yqjD gene" promotor_-10 complement(2086847..2086866) /Source="Nicolas_upshift_promotors" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2086869) /Source="Nicolas_upshifts" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2086881..2086885) /Source="Nicolas_upshift_promotors" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2087257..2087679) /gene="yqjC" /locus_tag="BSU_23930" /old_locus_tag="BSU23930" /EC_number="5.1.99.1" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methylmalonyl-CoA epimerase" /protein_id="NP_390273.2" /db_xref="EnsemblGenomes-Gn:BSU23930" /db_xref="EnsemblGenomes-Tr:CAB14324" /db_xref="GOA:P54540" /db_xref="InterPro:IPR017515" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11732" /db_xref="UniProtKB/Swiss-Prot:P54540" /translation="MNRLDHIGIAVFSIKDARSFYENVLGLAFLHQETVEEQKVNVAF FQAGSVKLELIEPLTADSPVHLFLEKKGQGLHHIAFLCNCLSEQLQALSDQHVQLIDR FPRQGANGKKIAFISPRETNGVLVELCEPKGDQHNEHE*" /label="yqjC CDS" gene complement(2087257..2087679) /gene="yqjC" /locus_tag="BSU_23930" /old_locus_tag="BSU23930" /label="yqjC gene" promotor_-35 2087708..2087715 /Source="Nicolas_upshift_promotors" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2087729..2087748 /Source="Nicolas_upshift_promotors" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2087743..2087896 /Source="Nicolas_S_feature" /locus_tag="new_2488815_2488968" /HighExp="LPhT, Etha, dia15, Salt, M9-stat, LBGstat, Heat, BC, T-0.40H, HiOs" /AntisenseName="yqjB" /AntisenseCor="-0.57221813594264503" /AntisenseRegPval="-24.1" /CDS_PredictionProba="0.99822200000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S907" upshifts 2087743 /Source="Nicolas_upshifts" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="upshifts" downshifts 2087853 /Source="Nicolas_upshifts" /id="D1252" /incds=0 /nref=1 /ntot=140 /MaxReadThrough="3.88708" /MaxDrop="3.25163" /score="3.10927996" /energy="-7" /TU="U1872" /idTUdmin="U1872" /TUdmin="-638" /isTUend="FALSE" /label="downshifts" CDS complement(2087881..2088411) /gene="yqjB" /locus_tag="BSU_23940" /old_locus_tag="BSU23940" /EC_number="2.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative L,D-transpeptidase" /protein_id="NP_390274.1" /db_xref="EnsemblGenomes-Gn:BSU23940" /db_xref="EnsemblGenomes-Tr:CAB14325" /db_xref="GOA:P54539" /db_xref="InterPro:IPR005490" /db_xref="SubtiList:BG11731" /db_xref="UniProtKB/Swiss-Prot:P54539" /translation="MRFFLCSIFMMISPIWPLGENPLPGDPYVIVNKRTNELAVILDN KVEGVYSVATGKTDDLTPEGEFSVTVKAENPYYRKKNIEGGSPDNPLGARWIGFDAKG TDGRIYGIHGTNREESVGKFVSNGCIRMHNDEVVHLFQTIPVGTRVLITDDNRSFEEI AIEHKALIKKQDIPIE*" /label="yqjB CDS" gene complement(2087881..2088411) /gene="yqjB" /locus_tag="BSU_23940" /old_locus_tag="BSU23940" /label="yqjB gene" S_feature 2087898..2088533 /Source="Nicolas_S_feature" /locus_tag="new_2488970_2489605" /HighExp="LPhT, H2O2, BC, Salt, dia15, M9-stat, Heat, LBGstat, T5.0H, Etha" /AntisenseName="yqjB" /AntisenseCor="-0.31126010332536502" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S908" promotor_-10 complement(2088428..2088439) /Source="Nicolas_upshift_promotors" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2088435) /Source="Nicolas_upshifts" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2088454..2088460) /Source="Nicolas_upshift_promotors" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2088463..2089431) /gene="yqjA" /locus_tag="BSU_23950" /old_locus_tag="BSU23950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390275.2" /db_xref="EnsemblGenomes-Gn:BSU23950" /db_xref="EnsemblGenomes-Tr:CAB14326" /db_xref="GOA:P54538" /db_xref="InterPro:IPR010343" /db_xref="InterPro:IPR021062" /db_xref="SubtiList:BG11730" /db_xref="UniProtKB/Swiss-Prot:P54538" /translation="MFKIGYRTIKTALGTALAIYISQLLHLQNFASAGIITILCIQIT QKRSLQASWARFSACCLAIAFSYLFFELIGYHPFVIGALLLIFIPITVLLKINEGIVT SSVIILHLYMSGGITPTFIWNEVQLITVGIGVALLMNLYMPSLDRKLIAYRKKIEDNF AVIFAEIERYLLTGEQDWSGKEIPETHQLITEAKNLAYRDVQNHILRYENLHYHYFKM REKQFEIIERLLPKVTSISITVDQGKMIAEFIHDLREAIHPGNTAYKFLKRLADMRKE FEEMPLPATREEFEARAALFHLLGEMEQYLVIKSYFKGIKAQKSLG*" /label="yqjA CDS" gene complement(2088463..2089431) /gene="yqjA" /locus_tag="BSU_23950" /old_locus_tag="BSU23950" /label="yqjA gene" downshifts complement(2088479) /Source="Nicolas_upshifts" /id="D1253" /incds=0 /nref=79 /ntot=223 /MaxReadThrough="2.22356" /MaxDrop="3.94894" /score="1.98299685" /energy="-14.1" /TU="NA" /idTUdmin="U1874" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2089502..2090224) /gene="artR" /locus_tag="BSU_23960" /old_locus_tag="BSU23960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter (ATP-binding protein)" /protein_id="NP_390276.1" /db_xref="EnsemblGenomes-Gn:BSU23960" /db_xref="EnsemblGenomes-Tr:CAB14327" /db_xref="GOA:P54537" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11729" /db_xref="UniProtKB/Swiss-Prot:P54537" /translation="MIKVEKLSKSFGKHEVLKNISTTIAEGEVVAVIGPSGSGKSTFL RCLNLLEKPNGGTITIKDTEITKPKTNTLKVRENIGMVFQHFHLFPHKTVLENIMYAP VNVKKESKQAAQEKAEDLLRKVGLFEKRNDYPNRLSGGQKQRVAIARALAMNPDIMLF DEPTSALDPEMVKEVLQVMKELVETGMTMVIVTHEMGFAKEVADRVLFMDQGMIVEDG NPKEFFMSPKSKRAQDFLEKIL*" /label="artR CDS" gene complement(2089502..2090224) /gene="artR" /locus_tag="BSU_23960" /old_locus_tag="BSU23960" /label="artR gene" downshifts complement(2089513) /Source="Nicolas_upshifts" /id="D1254" /incds=0 /nref=30 /ntot=152 /MaxReadThrough="4.81216" /MaxDrop="4.0342" /score="0.346345754" /energy="-7" /TU="U1874" /idTUdmin="U1874" /TUdmin="-1034" /isTUend="FALSE" /label="downshifts" CDS complement(2090217..2090876) /gene="artQ" /locus_tag="BSU_23970" /old_locus_tag="BSU23970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter (permease)" /protein_id="NP_390277.1" /db_xref="EnsemblGenomes-Gn:BSU23970" /db_xref="EnsemblGenomes-Tr:CAB14328" /db_xref="GOA:P54536" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11728" /db_xref="UniProtKB/Swiss-Prot:P54536" /translation="MNLDFSATIPQIPFILEGLAITLKIVVVSAIIGLILGIVLSLCK ISTFRPFIWIADFYTSVFRGTPLVLQLMIVYFGLPQLLGFQIDQFWAAVVALSLNSAA YVSEIIRAGINAIDKGQKEAAVALGVPYGKMMKDLLLPQAFKNISPAIVNELITLTKE SAIVTVIGLGDVMRRAYQAGAATYNYLEPLIIAGLIYYVLVLILTFIGKAVERKLKSN D*" /label="artQ CDS" gene complement(2090217..2090876) /gene="artQ" /locus_tag="BSU_23970" /old_locus_tag="BSU23970" /label="artQ gene" S_feature complement(2090877..2090956) /Source="Nicolas_S_feature" /locus_tag="new_2491949_2492028_c" /HighExp="S1, S2, ferm, MG 15, Fru, Glu, BMM, S3, UNK1, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S909" CDS complement(2090957..2091724) /gene="artP" /locus_tag="BSU_23980" /old_locus_tag="BSU23980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter binding lipoprotein" /protein_id="NP_390278.1" /db_xref="EnsemblGenomes-Gn:BSU23980" /db_xref="EnsemblGenomes-Tr:CAB14329" /db_xref="GOA:P54535" /db_xref="InterPro:IPR001320" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11727" /db_xref="UniProtKB/Swiss-Prot:P54535" /translation="MKKWLLLLVAACITFALTACGSSNSGSESGKKKLIMGTSADYKP FEYKEGDNIVGFDVELAKALAKKAGYEIEVQDMDFNSLITALKSKQVDLVLSGMTPTP ERKKQVDFSDVYYTANHMIVSKKDSGIQSLKDLKGKTVGVQLGSIQEEKGKELSPEYG FKTEDRNRISDLVQEIKSDRFDAAIIEDIVAEGYFKSNDDLQGFVIPDAKAEEAGSAI AFRKDSELTDKFNKALKEMEDNGELEKLKKKWFTGEK*" /label="artP CDS" gene complement(2090957..2091724) /gene="artP" /locus_tag="BSU_23980" /old_locus_tag="BSU23980" /label="artP gene" promotor_-10 complement(2091774..2091793) /Source="Nicolas_upshift_promotors" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2091789) /Source="Nicolas_upshifts" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2091808..2091815) /Source="Nicolas_upshift_promotors" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2091992..2092429) /gene="brxB" /locus_tag="BSU_23990" /old_locus_tag="BSU23990" /experiment="publication(s) with functional evidences, PMID:21749987, 24313874, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21749987, 24313874, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacilliredoxin B (de-bacillithiolation)" /protein_id="NP_390279.1" /db_xref="EnsemblGenomes-Gn:BSU23990" /db_xref="EnsemblGenomes-Tr:CAB14330" /db_xref="InterPro:IPR009474" /db_xref="SubtiList:BG11726" /db_xref="UniProtKB/Swiss-Prot:P54534" /translation="MNMDFNLFMNDIVRQARQEITAAGYTELKTAEEVDEALTKKGTT LVMVNSVCGCAGGIARPAAYHSVHYDKRPDQLVTVFAGQDKEATARARDYFEGYPPSS PSFAILKDGKIMKMVERHEIEGHEPMAVVAKLQEAFEEYCEEV*" /label="brxB CDS" gene complement(2091992..2092429) /gene="brxB" /locus_tag="BSU_23990" /old_locus_tag="BSU23990" /label="brxB gene" downshifts complement(2092001) /Source="Nicolas_upshifts" /id="D1255" /incds=0 /nref=252 /ntot=266 /MaxReadThrough="3.9242" /MaxDrop="7.06654" /score="21.489397" /energy="-11.8" /TU="U1875" /idTUdmin="U1875" /TUdmin="-200" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2092453..2092472) /Source="Nicolas_upshift_promotors" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="promotor_-10" upshifts complement(2092474) /Source="Nicolas_upshifts" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="upshifts" promotor_-35 complement(2092487..2092494) /Source="Nicolas_upshift_promotors" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="promotor_-35" promotor_-35 2092527..2092533 /Source="Nicolas_upshift_promotors" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2092546 /Source="Nicolas_upshifts" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2092548..2092566 /Source="Nicolas_upshift_promotors" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2092590..2093483 /gene="bmrU" /locus_tag="BSU_24000" /old_locus_tag="BSU24000" /EC_number="2.7.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7961792, 8098708, 10220166, 17114254, 17535816; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lipid kinase BmrU" /protein_id="NP_390280.2" /db_xref="EnsemblGenomes-Gn:BSU24000" /db_xref="EnsemblGenomes-Tr:CAB14331" /db_xref="GOA:P39074" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG10302" /db_xref="UniProtKB/Swiss-Prot:P39074" /translation="MSHRKALLIHNGNAGNKNIEKALGAVVPVLSHHLDEVIIKQTKK KDDAYHFCRSIDDSVDTVFILGGDGTIHQCINAISALERKPAVGILPGGTCNDFSRVL GIPQNLAKAAEALMAGKKTSVDVCQMNDRYFLNFWGIGLIAETSNQINETEKALLGKI SYFTSALRTVSSAASFPMTLKIDGEEIKEEAVMLLVMNGQYIGTNRIPLPDASIEDGL LDVLICRNTNLTALRELMSMEQGSIDRFTGELSYVQASRIEIETDTAKKADMDGEVYT HTPAVIQVLPQHIDMLVPANE*" /label="bmrU CDS" gene 2092590..2093483 /gene="bmrU" /locus_tag="BSU_24000" /old_locus_tag="BSU24000" /label="bmrU gene" promotor_-35 2093516..2093523 /Source="Nicolas_upshift_promotors" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2093539..2093558 /Source="Nicolas_upshift_promotors" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2093547 /Source="Nicolas_upshifts" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="upshifts" CDS 2093584..2094753 /gene="bmr" /locus_tag="BSU_24010" /old_locus_tag="BSU24010" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10200972, 10961951, 11321573, 15849754, 16850406, 25756668" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10200972, 10961951, 11321573, 15849754, 16850406, 25756668; Product type t : transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_390281.2" /db_xref="EnsemblGenomes-Gn:BSU24010" /db_xref="EnsemblGenomes-Tr:CAB14332" /db_xref="GOA:P33449" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10303" /db_xref="UniProtKB/Swiss-Prot:P33449" /translation="MEKKNITLTILLTNLFIAFLGIGLVIPVTPTIMNELHLSGTAVG YMVACFAITQLIVSPIAGRWVDRFGRKIMIVIGLLFFSVSEFLFGIGKTVEMLFISRM LGGISAAFIMPGVTAFIADITTIKTRPKALGYMSAAISTGFIIGPGIGGFLAEVHSRL PFFFAAAFALLAAILSILTLREPERNPENQEIKGQKTGFKRIFAPMYFIAFLIILISS FGLASFESLFALFVDHKFGFTASDIAIMITGGAIVGAITQVVLFDRFTRWFGEIHLIR YSLILSTSLVFLLTTVHSYVAILLVTVTVFVGFDLMRPAVTTYLSKIAGNEQGFAGGM NSMFTSIGNVFGPIIGGMLFDIDVNYPFYFATVTLAIGIALTIAWKAPAHLKAST*" /label="bmr CDS" gene 2093584..2094753 /gene="bmr" /locus_tag="BSU_24010" /old_locus_tag="BSU24010" /label="bmr gene" downshifts 2094736 /Source="Nicolas_upshifts" /id="D1256" /incds=0 /nref=6 /ntot=31 /MaxReadThrough="4.82186" /MaxDrop="5.02667" /score="-1.94257488" /energy="-18" /TU="U1876,U1877" /idTUdmin="U1876" /TUdmin="-924" /isTUend="FALSE" /label="downshifts" CDS 2094826..2095662 /gene="bmrR" /locus_tag="BSU_24020" /old_locus_tag="BSU24020" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11201751, 11839496, 12682015, 14985361, 18658145, 21690368" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11201751, 11839496, 12682015, 14985361, 18658145, 21690368; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MerR family)" /protein_id="NP_390282.2" /db_xref="EnsemblGenomes-Gn:BSU24020" /db_xref="EnsemblGenomes-Tr:CAB14333" /db_xref="GOA:P39075" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="PDB:1BOW" /db_xref="PDB:1EXI" /db_xref="PDB:1EXJ" /db_xref="PDB:1R8E" /db_xref="PDB:2BOW" /db_xref="PDB:3D6Y" /db_xref="PDB:3D6Z" /db_xref="PDB:3D70" /db_xref="PDB:3D71" /db_xref="PDB:3IAO" /db_xref="PDB:3Q1M" /db_xref="PDB:3Q2Y" /db_xref="PDB:3Q3D" /db_xref="PDB:3Q5P" /db_xref="PDB:3Q5R" /db_xref="PDB:3Q5S" /db_xref="SubtiList:BG10304" /db_xref="UniProtKB/Swiss-Prot:P39075" /translation="MKESYYSIGEVSKLANVSIKALRYYDKIDLFKPAYVDPDTSYRY YTDSQLIHLDLIKSLKYIGTPLEEMKKAQDLEMEELFAFYTEQERQIREKLDFLSALE QTISLVKKRMKRQMEYPALGEVFVLDEEEIRIIQTEAEGIGPENVLNASYSKLKKFIE SADGFTNNSYGATFSFQPYTSIDEMTYRHIFTPVLTNKQISSITPDMEITTIPKGRYA CIAYNFSPEHYFLNLQKLIKYIADRQLTVVSDVYELIIPIHYSPKKQEEYRVEMKIRI AE*" /label="bmrR CDS" gene 2094826..2095662 /gene="bmrR" /locus_tag="BSU_24020" /old_locus_tag="BSU24020" /label="bmrR gene" downshifts 2095660 /Source="Nicolas_upshifts" /id="D1257" /incds=0 /nref=5 /ntot=156 /MaxReadThrough="4.1979" /MaxDrop="4.72542" /score="5.00815505" /energy="-15.7" /TU="NA" /idTUdmin="U1876" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2095724) /Source="Nicolas_upshifts" /id="D1258" /incds=0 /nref=15 /ntot=247 /MaxReadThrough="3.01431" /MaxDrop="6.04069" /score="8.5296919" /energy="-16.8" /TU="U1879" /idTUdmin="U1878" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(2095724..2096998) /gene="bkdB" /locus_tag="BSU_24030" /old_locus_tag="BSU24030" /EC_number="2.3.1.168" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E2 subunit (lipoamide acyltransferase)" /protein_id="NP_390283.1" /db_xref="EnsemblGenomes-Gn:BSU24030" /db_xref="EnsemblGenomes-Tr:CAB14334" /db_xref="GOA:P37942" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10305" /db_xref="UniProtKB/Swiss-Prot:P37942" /translation="MAIEQMTMPQLGESVTEGTISKWLVAPGDKVNKYDPIAEVMTDK VNAEVPSSFTGTITELVGEEGQTLQVGEMICKIETEGANPAEQKQEQPAASEAAENPV AKSAGAADQPNKKRYSPAVLRLAGEHGIDLDQVTGTGAGGRITRKDIQRLIETGGVQE QNPEELKTAAPAPKSASKPEPKEETSYPASAAGDKEIPVTGVRKAIASNMKRSKTEIP HAWTMMEVDVTNMVAYRNSIKDSFKKTEGFNLTFFAFFVKAVAQALKEFPQMNSMWAG DKIIQKKDINISIAVATEDSLFVPVIKNADEKTIKGIAKDITGLAKKVRDGKLTADDM QGGTFTVNNTGSFGSVQSMGIINYPQAAILQVESIVKRPVVMDNGMIAVRDMVNLCLS LDHRVLDGLVCGRFLGRVKQILESIDEKTSVY*" /label="bkdB CDS" gene complement(2095724..2096998) /gene="bkdB" /locus_tag="BSU_24030" /old_locus_tag="BSU24030" /label="bkdB gene" CDS complement(2097021..2098004) /gene="bkdAB" /locus_tag="BSU_24040" /old_locus_tag="BSU24040" /EC_number="1.2.4.4" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E1 subunit" /protein_id="NP_390284.1" /db_xref="EnsemblGenomes-Gn:BSU24040" /db_xref="EnsemblGenomes-Tr:CAB14335" /db_xref="GOA:P37941" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG10306" /db_xref="UniProtKB/Swiss-Prot:P37941" /translation="MSVMSYIDAINLAMKEEMERDSRVFVLGEDVGRKGGVFKATAGL YEQFGEERVMDTPLAESAIAGVGIGAAMYGMRPIAEMQFADFIMPAVNQIISEAAKIR YRSNNDWSCPIVVRAPYGGGVHGALYHSQSVEAIFANQPGLKIVMPSTPYDAKGLLKA AVRDEDPVLFFEHKRAYRLIKGEVPADDYVLPIGKADVKREGDDITVITYGLCVHFAL QAAERLEKDGISAHVVDLRTVYPLDKEAIIEAASKTGKVLLVTEDTKEGSIMSEVAAI ISEHCLFDLDAPIKRLAGPDIPAMPYAPTMEKYFMVNPDKVEAAMRELAEF*" /label="bkdAB CDS" gene complement(2097021..2098004) /gene="bkdAB" /locus_tag="BSU_24040" /old_locus_tag="BSU24040" /label="bkdAB gene" CDS complement(2098018..2099010) /gene="bkdAA" /locus_tag="BSU_24050" /old_locus_tag="BSU24050" /EC_number="1.2.4.4" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E1 subunit" /protein_id="NP_390285.1" /db_xref="EnsemblGenomes-Gn:BSU24050" /db_xref="EnsemblGenomes-Tr:CAB14336" /db_xref="GOA:P37940" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR034616" /db_xref="SubtiList:BG10307" /db_xref="UniProtKB/Swiss-Prot:P37940" /translation="MSTNRHQALGLTDQEAVDMYRTMLLARKIDERMWLLNRSGKIPF VISCQGQEAAQVGAAFALDREMDYVLPYYRDMGVVLAFGMTAKDLMMSGFAKAADPNS GGRQMPGHFGQKKNRIVTGSSPVTTQVPHAVGIALAGRMEKKDIAAFVTFGEGSSNQG DFHEGANFAAVHKLPVIFMCENNKYAISVPYDKQVACENISDRAIGYGMPGVTVNGND PLEVYQAVKEARERARRGEGPTLIETISYRLTPHSSDDDDSSYRGREEVEEAKKSDPL LTYQAYLKETGLLSDEIEQTMLDEIMAIVNEATDEAENAPYAAPESALDYVYAK*" /label="bkdAA CDS" gene complement(2098018..2099010) /gene="bkdAA" /locus_tag="BSU_24050" /old_locus_tag="BSU24050" /label="bkdAA gene" CDS complement(2099032..2100456) /gene="lpdV" /locus_tag="BSU_24060" /old_locus_tag="BSU24060" /EC_number="1.8.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E3 subunit (dihydrolipoamide dehydrogenase)" /protein_id="NP_390286.2" /db_xref="EnsemblGenomes-Gn:BSU24060" /db_xref="EnsemblGenomes-Tr:CAB14337" /db_xref="GOA:P54533" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11725" /db_xref="UniProtKB/Swiss-Prot:P54533" /translation="MATEYDVVILGGGTGGYVAAIRAAQLGLKTAVVEKEKLGGTCLH KGCIPSKALLRSAEVYRTAREADQFGVETAGVSLNFEKVQQRKQAVVDKLAAGVNHLM KKGKIDVYTGYGRILGPSIFSPLPGTISVERGNGEENDMLIPKQVIIATGSRPRMLPG LEVDGKSVLTSDEALQMEELPQSIIIVGGGVIGIEWASMLHDFGVKVTVIEYADRILP TEDLEISKEMESLLKKKGIQFITGAKVLPDTMTKTSDDISIQAEKDGETVTYSAEKML VSIGRQANIEGIGLENTDIVTENGMISVNESCQTKESHIYAIGDVIGGLQLAHVASHE GIIAVEHFAGLNPHPLDPTLVPKCIYSSPEAASVGLTEDEAKANGHNVKIGKFPFMAI GKALVYGESDGFVKIVADRDTDDILGVHMIGPHVTDMISEAGLAKVLDATPWEVGQTI HPHPTLSEAIGEAALAADGKAIHF*" /label="lpdV CDS" gene complement(2099032..2100456) /gene="lpdV" /locus_tag="BSU_24060" /old_locus_tag="BSU24060" /label="lpdV gene" CDS complement(2100477..2101568) /gene="buk" /locus_tag="BSU_24070" /old_locus_tag="BSU24070" /EC_number="2.7.2.-" /EC_number="2.7.2.7" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain fatty-acid kinase" /protein_id="NP_390287.2" /db_xref="EnsemblGenomes-Gn:BSU24070" /db_xref="EnsemblGenomes-Tr:CAB14338" /db_xref="GOA:P54532" /db_xref="InterPro:IPR000890" /db_xref="InterPro:IPR011245" /db_xref="InterPro:IPR023865" /db_xref="SubtiList:BG11724" /db_xref="UniProtKB/Swiss-Prot:P54532" /translation="MKVLHDEKRILTINPGSTSTKIGVFHNERSIFEKTLRHNIEELQ RFDRIIDQYEFRKNHILETLHEQGINISKFDAVCARGGLLRPIEGGTYVVNDEMIEDL KSGYAGQHASNLGGIIAREIADGLNIPSYIVDPVVVDEMSVLAKVSGMPEIERKSIFH ALNQKAVARKAAASLGKRYENMKMIITHMGGGITIGVHDRGRVVDVNNGLHGEGPFSP ERAGTVPAGDLVDLCFSGEYTKEEIMKKLVGTGGLLGYLGTNDAVKVEQMIQGGDEKA RFIYDAMAYQVAKEIGAASAALKGEVEAIVLTGGLAYGKSFVSAIRSYIDWISDVLVY PGENELQSLAQGALRVLQGEEQSKQYRIE*" /label="buk CDS" gene complement(2100477..2101568) /gene="buk" /locus_tag="BSU_24070" /old_locus_tag="BSU24070" /label="buk gene" CDS complement(2101587..2102681) /gene="bcd" /locus_tag="BSU_24080" /old_locus_tag="BSU24080" /EC_number="1.4.1.8" /EC_number="1.4.1.-" /EC_number="1.4.1.9" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:4204435, 10094682, 12427936, 15241682, 20935095, 21856856, 22720735, 28165735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204435, 10094682, 12427936, 15241682, 20935095, 21856856, 22720735, 28165735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain amino acid dehydrogenase" /protein_id="NP_390288.1" /db_xref="EnsemblGenomes-Gn:BSU24080" /db_xref="EnsemblGenomes-Tr:CAB14339" /db_xref="GOA:P54531" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR016211" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11723" /db_xref="UniProtKB/Swiss-Prot:P54531" /translation="MELFKYMEKYDYEQLVFCQDEQSGLKAIIAIHDTTLGPALGGTR MWTYENEEAAIEDALRLARGMTYKNAAAGLNLGGGKTVIIGDPRKDKNEEMFRAFGRY IQGLNGRYITAEDVGTTVEDMDIIHDETDYVTGISPAFGSSGNPSPVTAYGVYRGMKA AAKAAFGTDSLEGKTIAVQGVGNVAYNLCRHLHEEGANLIVTDINKQSVQRAVEDFGA RAVDPDDIYSQDCDIYAPCALGATINDDTIKQLKAKVIAGAANNQLKETRHGDQIHEM GIVYAPDYVINAGGVINVADELYGYNAERALKKVEGIYGNIERVLEISQRDGIPAYLA ADRLAEERIERMRRSRSQFLQNGHSVLSRR*" /label="bcd CDS" gene complement(2101587..2102681) /gene="bcd" /locus_tag="BSU_24080" /old_locus_tag="BSU24080" /label="bcd gene" CDS complement(2102693..2103592) /gene="ptb" /locus_tag="BSU_24090" /old_locus_tag="BSU24090" /EC_number="2.3.1.19" /EC_number="2.3.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28165735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28165735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphate BCFA and butyryl coenzyme A transferase" /protein_id="NP_390289.2" /db_xref="EnsemblGenomes-Gn:BSU24090" /db_xref="EnsemblGenomes-Tr:CAB14340" /db_xref="GOA:P54530" /db_xref="InterPro:IPR002505" /db_xref="InterPro:IPR012147" /db_xref="InterPro:IPR014079" /db_xref="SubtiList:BG11722" /db_xref="UniProtKB/Swiss-Prot:P54530" /translation="MKLKDLIGKASIHKNKTIAVAHAEDEEVIRAVKLAAEHLSARFL LTGDSKKLNELTSSMQGHQVEIVHANTPEESAKLAVRAVHHKTADVLMKGNVPTSVLL KAVLNRQEGLRSASVLSHVAVFDIPDFDRLMFVTDSAMNIAPSLEELRQILQNAVHVA HAVGNNMPKAAALAAVETVNPKMEATVNAAALAQMYKRGQIKGCIVDGPLALDNAVSQ IAAAQKKISGDVAGNADILLVPTIEAGNILYKSLIYFAKASVAAVITGAKAPIALTSR ADSAENKLYSIALAICASEEYTH*" /label="ptb CDS" gene complement(2102693..2103592) /gene="ptb" /locus_tag="BSU_24090" /old_locus_tag="BSU24090" /label="ptb gene" misc_feature complement(2103628..2103647) /Source="Nicolas_upshift_promotors" /id="U1878" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.764235764235764" /psig="0.764235764235764" /xcortree=340 /SigmaFactorBS="tgcacgaatgtttcggtatacctggtatgacagcacccttaa gagcTGGCATGGAACTTGCATAATaaaaggcggagtcgaaacaagaaaggtggtaaca g" /listShort="ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2103633) /Source="Nicolas_upshifts" /id="U1878" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.764235764235764" /psig="0.764235764235764" /xcortree=340 /SigmaFactorBS="tgcacgaatgtttcggtatacctggtatgacagcacccttaa gagcTGGCATGGAACTTGCATAATaaaaggcggagtcgaaacaagaaaggtggtaaca g" /listShort="ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2103635..2103716) /Source="Nicolas_S_feature" /locus_tag="new_2504707_2504788_c" /HighExp="Cold, LBGtran, G180, Lbexp, G135, G150, LBGexp, Diami, Oxctl, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S910" CDS complement(2103717..2105795) /gene="bkdR" /locus_tag="BSU_24100" /old_locus_tag="BSU24100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 16585774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 16585774; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_390290.1" /db_xref="EnsemblGenomes-Gn:BSU24100" /db_xref="EnsemblGenomes-Tr:CAB14341" /db_xref="GOA:P54529" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR025662" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11721" /db_xref="UniProtKB/Swiss-Prot:P54529" /translation="MQKVLIVGAGKRGTALLHILIKTAIIDIIAVVDKDPEAPGLKEA EQYGIAVSSDWKPYIQQKPDIVIHTTGDQAVFDELLQRKHEDTIVMPGKMAYIVFQLM EEKQHLIQMLKEQTYKYDRIFNSTHDGMIFIDINEEIILFNHMAEKMVGKKREEVIGR PIKEVIPSTKMPRILKTRVPEYNQKQLLGDHLQIVTTRLPIIDEGGRLLGALCVFKDI TDAVELAEEVTNLKQVRTMLEAIIQSSDEAISVVDENGIGLLINKAYTKMTGLSEKEV IGKPANTDISEGESMHLKVLETRRPVRGVRMKVGPNEKEVIVNVAPVIVDGILKGSVG VIHDVSEIKMLTAELNRARQIIRTLEAKYTFDDIIGKSEQMLVALEQAKLGAKTPATI LLRGESGTGKELFAHAIHNESDRKYNKFIRVNCAALSENLLESELFGYEDGAFSGAKR GGKKGLFEEANNGSIFLDEIGELTQNMQAKLLRVLQEKEIVRVGGTKAIPVNVRVIAA TNVNIEKAMADGTFREDLYYRINRYPISIPPLRQRLEDIEALSVRLIQKINRDYGRNV KGLSQQALRALSAYHWPGNVRELENVLGRAMIFLNPHMEWIEKDHLPVFELEQKENDT DQGTGFDFPDIEGEKLSVAVEKFEAHLIQQTLEKHHFNRTKTAKALGVSIRNLYYKMD KYGLANEGMQ*" /label="bkdR CDS" gene complement(2103717..2105795) /gene="bkdR" /locus_tag="BSU_24100" /old_locus_tag="BSU24100" /label="bkdR gene" promotor_-10 complement(2105855..2105874) /Source="Nicolas_upshift_promotors" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2105872) /Source="Nicolas_upshifts" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2105882..2105889 /Source="Nicolas_upshift_promotors" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2105891..2105894) /Source="Nicolas_upshift_promotors" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2105903..2105922 /Source="Nicolas_upshift_promotors" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2105910 /Source="Nicolas_upshifts" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="upshifts" CDS 2105948..2106184 /gene="yqzF" /locus_tag="BSU_24110" /old_locus_tag="BSU24110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390291.1" /db_xref="EnsemblGenomes-Gn:BSU24110" /db_xref="EnsemblGenomes-Tr:CAB14342" /db_xref="GOA:O32015" /db_xref="InterPro:IPR020138" /db_xref="SubtiList:BG13772" /db_xref="UniProtKB/Swiss-Prot:O32015" /translation="MSRLLALLILVIPGAISALGIKLMRDTLFGHTIKPFSALWLQGL SGFIFFAIGLYVLAGFILYRDRKRNQVSPRFRKR*" /label="yqzF CDS" gene 2105948..2106184 /gene="yqzF" /locus_tag="BSU_24110" /old_locus_tag="BSU24110" /label="yqzF gene" downshifts 2106175 /Source="Nicolas_upshifts" /id="D1259" /incds=0 /nref=64 /ntot=230 /MaxReadThrough="2.80342" /MaxDrop="5.10794" /score="42.7247617" /energy="-11.9" /TU="NA" /idTUdmin="U1880" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2106226..2107131) /gene="mmgF" /locus_tag="BSU_24120" /old_locus_tag="BSU24120" /EC_number="4.1.3.30" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12706720, 17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12706720, 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-methylisocitrate lyase" /protein_id="NP_390292.1" /db_xref="EnsemblGenomes-Gn:BSU24120" /db_xref="EnsemblGenomes-Tr:CAB14343" /db_xref="GOA:P54528" /db_xref="InterPro:IPR012695" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018523" /db_xref="SubtiList:BG11720" /db_xref="UniProtKB/Swiss-Prot:P54528" /translation="MSWIVNKQSSQEELAGRFRKLMSAPDILQIPGAHDGMAALLAKE AGFSAIYLSGAAYTASRGLPDLGIITSAEIAERAKDLVRAADLPLLVDIDTGFGGVLN AARTAREMLEARVAAVQMEDQQLPKKCGHLNGKQLVPIKEMAQKIKAIKQAAPSLIVV ARTDARAQEGLDAAIKRSEAYIEAGADAIFPEALQAENEFRQFAERIPVPLLANMTEF GKTPYYRADEFEDMGFHMVIYPVTSLRAAAKACERMFGLMKEHGSQKEGLHDMQTRKE LYDTISYYDYEALDKTIAKTVLPDE*" /label="mmgF CDS" gene complement(2106226..2107131) /gene="mmgF" /locus_tag="BSU_24120" /old_locus_tag="BSU24120" /label="mmgF gene" downshifts complement(2106229) /Source="Nicolas_upshifts" /id="D1260" /incds=0 /nref=29 /ntot=69 /MaxReadThrough="2.12559" /MaxDrop="5.62" /score="33.814061" /energy="-11.9" /TU="NA" /idTUdmin="U1884" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2107149..2108567) /gene="mmgE" /locus_tag="BSU_24130" /old_locus_tag="BSU24130" /EC_number="4.2.1.79" /EC_number="4.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-methylcitrate dehydratase (promiscuous)" /protein_id="NP_390293.2" /db_xref="EnsemblGenomes-Gn:BSU24130" /db_xref="EnsemblGenomes-Tr:CAB14344" /db_xref="GOA:P45859" /db_xref="InterPro:IPR005656" /db_xref="InterPro:IPR012705" /db_xref="InterPro:IPR036148" /db_xref="SubtiList:BG11323" /db_xref="UniProtKB/Swiss-Prot:P45859" /translation="MPKTDRVIEEITDYVLEKEITSAEAYTTAGHVLLDTLGCGILAL RYPECTKLLGPIVPGTTVPNGSKVPGTSYVLDPVRAAFNIGCMIRWLDYNDTWLAAEW GHPSDNLGGILAAADYVSRVRLSEGKEPLTVRDVLEMMIKAHEIQGVLALENSLNRVG LDHVLFVKVATTAVAAKLLGGGREEIKNALSNAWIDNAALRTYRHSPNTGSRKSWAAG DATSRGVHLALMSLKGEMGYPTALSAPGWGFQDVLFNKKEIKLARPLDAYVMENVLFK VSYPAEFHAQTAAESAVILHPQVKNRIDEIDRVVIRTHESAIRIIDKKGPLHNPADRD HCLQYITAIGLLFGDITAQHYEAETANDPRIDKLRDKMEVTENKTYTEDYLKPDKRSI SNAVQVHFKDGTSTEMVECEFPLGHRFRREEAVPKLLEKFSDNLKTHFPDKQHKHIYE RCTSYETLQTMRVNEFVDMFCM*" /label="mmgE CDS" gene complement(2107149..2108567) /gene="mmgE" /locus_tag="BSU_24130" /old_locus_tag="BSU24130" /label="mmgE gene" misc_feature complement(2107444..2107463) /Source="Nicolas_upshift_promotors" /id="U1881" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.997002997002997" /xcortree=616 /SigmaFactorBS="tatcaccgcacagcattatgaagctgaaacagcgaatgatcc gagaatagataaacttCGTGATAAAATGGAAGTGACtgaaaataaaacatataccgag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2107461) /Source="Nicolas_upshifts" /id="U1881" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.997002997002997" /xcortree=616 /SigmaFactorBS="tatcaccgcacagcattatgaagctgaaacagcgaatgatcc gagaatagataaacttCGTGATAAAATGGAAGTGACtgaaaataaaacatataccgag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2108582..2109700) /gene="mmgD" /locus_tag="BSU_24140" /old_locus_tag="BSU24140" /EC_number="2.3.3.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8759838, 17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759838, 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional citrate synthase/2-methylcitrate synthase" /protein_id="NP_390294.1" /db_xref="EnsemblGenomes-Gn:BSU24140" /db_xref="EnsemblGenomes-Tr:CAB14345" /db_xref="GOA:P45858" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="SubtiList:BG11322" /db_xref="UniProtKB/Swiss-Prot:P45858" /translation="MEEKQHYSPGLDGVIAAETHISYLDTQSSQILIRGYDLIELSET KSYLELVHLLLEGRLPEESEMETLERKINSASSLPADHLRLLELLPEDTHPMDGLRTG LSALAGYDRQIDDRSPSANKERAYQLLGKMPALTAASYRIINKKEPILPLQTLSYSAN FLYMMTGKLPSSLEEQIFDRSLVLYSEHEMPNSTFAARVIASTHSDLYGALTGAVASL KGNLHGGANEAVMYLLLEAKTTSDFEQLLQTKLKRKEKIMGFGHRVYMKKMDPRALMM KEALQQLCDKAGDHRLYEMCEAGERLMEKEKGLYPNLDYYAAPVYWMLGIPIPLYTPI FFSARTSGLCAHVIEQHANNRLFRPRVSYMGPRYQTKS*" /label="mmgD CDS" gene complement(2108582..2109700) /gene="mmgD" /locus_tag="BSU_24140" /old_locus_tag="BSU24140" /label="mmgD gene" CDS complement(2109734..2110873) /gene="mmgC" /locus_tag="BSU_24150" /old_locus_tag="BSU24150" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="propionyl-CoA dehydrogenase subunit" /protein_id="NP_390295.2" /db_xref="EnsemblGenomes-Gn:BSU24150" /db_xref="EnsemblGenomes-Tr:CAB14346" /db_xref="GOA:P45857" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="PDB:5LNX" /db_xref="SubtiList:BG11321" /db_xref="UniProtKB/Swiss-Prot:P45857" /translation="MHVTQEQVMMRKMVRDFARKEIAPAAEIMEKTDEFPFQLIKKMG KHGLMGIPVPEQYGGAGADVVSYILAIHEISRISAAVGVILSVHTSVGTNPILYFGNE EQKMKYIPNLASGDHLGAFALTEPHSGSDAGSLRTTAIKKNGKYLLNGSKIFITNGGA ADIYITFALTAPDQGRHGISAFIVEKNTPGFTVGKKERKLGLYGSNTTELIFDNAEVP EANLLGKEGDGFHIAMANLNVGRIGIAAQALGIAEAALEHAVDYAKQRVQFGRPIAAN QGISFKLADMATRAEAARHLVYHAADLHNRGLNCGKEASMAKQFASDAAVKAALDAVQ IYGGYGYMKDYPVERLLRDAKVTQIYEGTNEIQRLIISKYLLGGT*" /label="mmgC CDS" gene complement(2109734..2110873) /gene="mmgC" /locus_tag="BSU_24150" /old_locus_tag="BSU24150" /label="mmgC gene" CDS complement(2110901..2111764) /gene="mmgB" /locus_tag="BSU_24160" /old_locus_tag="BSU24160" /EC_number="1.1.1.157" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8759838, 18461320, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759838, 18461320, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hydroxybutyryl-CoA dehydrogenase" /protein_id="NP_390296.2" /db_xref="EnsemblGenomes-Gn:BSU24160" /db_xref="EnsemblGenomes-Tr:CAB14347" /db_xref="GOA:P45856" /db_xref="InterPro:IPR006108" /db_xref="InterPro:IPR006176" /db_xref="InterPro:IPR006180" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR022694" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11320" /db_xref="UniProtKB/Swiss-Prot:P45856" /translation="MEIKQIMVAGAGQMGSGIAQTAADAGFYVRMYDVNPEAAEAGLK RLKKQLARDAEKGKRTETEVKSVINRISISQTLEEAEHADIVIEAIAENMAAKTEMFK TLDRICPPHTILASNTSSLPITEIAAVTNRPQRVIGMHFMNPVPVMKLVEVIRGLATS EETALDVMALAEKMGKTAVEVNDFPGFVSNRVLLPMINEAIYCVYEGVAKPEAIDEVM KLGMNHPMGPLALADFIGLDTCLSIMEVLHSGLGDSKYRPCPLLRKYVKAGWLGKKSG RGFYDYEEKTS*" /label="mmgB CDS" gene complement(2110901..2111764) /gene="mmgB" /locus_tag="BSU_24160" /old_locus_tag="BSU24160" /label="mmgB gene" CDS complement(2111789..2112970) /gene="mmgA" /locus_tag="BSU_24170" /old_locus_tag="BSU24170" /EC_number="2.3.1.9" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16352833, 18246303, 19016856, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352833, 18246303, 19016856, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="degradative acetoacetyl-CoA thiolase" /protein_id="NP_390297.1" /db_xref="EnsemblGenomes-Gn:BSU24170" /db_xref="EnsemblGenomes-Tr:CAB14348" /db_xref="GOA:P45855" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020610" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020615" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="PDB:5LP7" /db_xref="SubtiList:BG11319" /db_xref="UniProtKB/Swiss-Prot:P45855" /translation="MRKTVIVSAARTPFGKFGGVLKEVKAAELGGIVMKEALQQAGVS GDDVEGNVMGMVVQAGSGQIPSRQAARLAGMPWSVPSETLNKVCASGLRAVTLCDQMI RAQDADILVAGGMESMSNIPYAVPAGRWGARMGDGELRDLMVYDGLTCAFDEVHMAVH GNTAAKEYAISRREQDEWALRSHARAAKAADEGKFQDEIVPVNWIGRKGKPNVVDKDE AIRRDTSLDQLAKLAPIYASDGSITAGNAPGVNDGAGAFVLMSEEKAAELGKRPLATI LGFSTTGMPAHELAAAPGFAINKLLKKNGLTVQDIDLFEVNEAFASVVLTCEKIVGFD LEKVNVNGGAIALGHPIGASGARILMTLVYELKRRGGGLGVAAICSGAAQGDAVLVQV H*" /label="mmgA CDS" gene complement(2111789..2112970) /gene="mmgA" /locus_tag="BSU_24170" /old_locus_tag="BSU24170" /label="mmgA gene" downshifts complement(2112550) /Source="Nicolas_upshifts" /id="D1261" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.17207" /MaxDrop="2.33167" /score="-0.949614429" /energy="-7.8" /TU="U1884" /idTUdmin="U1885" /TUdmin=550 /isTUend="FALSE" /label="downshifts" misc_feature complement(2112657..2112663) /Source="Nicolas_upshift_promotors" /id="U1882" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.0869130869130869" /xcortree=1497 /SigmaFactorBS="tgaataaagtctgtgcttccggccttcgcgctgtcactttat gtgatcaaatgattcGGGCGCAggatgcggacatacttgttgcgggggggatggaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2112660) /Source="Nicolas_upshifts" /id="U1882" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.0869130869130869" /xcortree=1497 /SigmaFactorBS="tgaataaagtctgtgcttccggccttcgcgctgtcactttat gtgatcaaatgattcGGGCGCAggatgcggacatacttgttgcgggggggatggaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box complement(2112884..2112984) /Source="Nicolas_upshift_promotors" /id="U1883" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1483 /SigmaFactorBS="aatgaggtgaaaccatgaggaaaacagtcattgtaagtgctg caagaactccatttggcaaattcggcggagttttgaaagaggtgaaagctgctgagct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2112924) /Source="Nicolas_upshifts" /id="U1883" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1483 /SigmaFactorBS="aatgaggtgaaaccatgaggaaaacagtcattgtaagtgctg caagaactccatttggcaaattcggcggagttttgaaagaggtgaaagctgctgagct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2113017..2113035) /Source="Nicolas_upshift_promotors" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2113035) /Source="Nicolas_upshifts" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2113051..2113056) /Source="Nicolas_upshift_promotors" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2113097..2113828) /gene="glpQ" /locus_tag="BSU_24180" /old_locus_tag="BSU24180" /EC_number="3.1.4.46" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6319195, 14563871, 21966272, 22843846, 24373430, 27780866" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6319195, 14563871, 21966272, 22843846, 24373430, 27780866; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glycerophosphodiester phosphodiesterase (exolytic cleavage of individual teichoic acid monomer units)" /protein_id="NP_390298.2" /db_xref="EnsemblGenomes-Gn:BSU24180" /db_xref="EnsemblGenomes-Tr:CAB14349" /db_xref="GOA:P54527" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="SubtiList:BG11719" /db_xref="UniProtKB/Swiss-Prot:P54527" /translation="MTKIFAHRGASGQFPENTMLAFEKGIEAGADGIELDVQLTKDGR IVVIHDERLNRTTSLKGFVKDTAYDEVKTANAAAGHDQAYSDIKVPLLEDVLSWAVKK DFLINIELKNSVIRYEGMEEKVLEAVKRFNVEDRVILSTFNHDSLALCARLAPHIERA VLTSDVLYQADRYIASIPASGYHPKINSPGVTDEVLKKMRNGLIKVRPYTVNRPEDMK RLIEAGADGMFTDFPEKASALLKNE*" /label="glpQ CDS" gene complement(2113097..2113828) /gene="glpQ" /locus_tag="BSU_24180" /old_locus_tag="BSU24180" /label="glpQ gene" downshifts complement(2113104) /Source="Nicolas_upshifts" /id="D1262" /incds=0 /nref=31 /ntot=180 /MaxReadThrough="0.31166" /MaxDrop="4.10202" /score="-0.949614429" /energy="-7.8" /TU="NA" /idTUdmin="U1885" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2113851..2113870) /Source="Nicolas_upshift_promotors" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2113862) /Source="Nicolas_upshifts" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2113885..2113888) /Source="Nicolas_upshift_promotors" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2113907..2114527) /gene="yqiI" /locus_tag="BSU_24190" /old_locus_tag="BSU24190" /EC_number="3.5.1.28" /experiment="publication(s) with functional evidences, PMID:22843846" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22843846; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_390299.2" /db_xref="EnsemblGenomes-Gn:BSU24190" /db_xref="EnsemblGenomes-Tr:CAB14350" /db_xref="GOA:P54525" /db_xref="InterPro:IPR002508" /db_xref="SubtiList:BG11717" /db_xref="UniProtKB/Swiss-Prot:P54525" /translation="MRMLWRSLALCGLALTLAPCAQAAEPIEGKTVYIDAGHGGEDSG AVGNGLFEKDINLAVSEHVTDKLKEEGANPVASRSDDHFLTLEERVAKASANQADLFV SIHVNSGVASASGTETYFQSDYEGENSRRLASDIQSQLVSSLQTRDRGVKESDFYVIT YSQMPSVLAELGFITNSSDADKLGSEEYQQKAADAIVNGIDSYYDQ*" /label="yqiI CDS" gene complement(2113907..2114527) /gene="yqiI" /locus_tag="BSU_24190" /old_locus_tag="BSU24190" /label="yqiI gene" CDS complement(2114542..2114835) /gene="yqiH" /locus_tag="BSU_24200" /old_locus_tag="BSU24200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22843846; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390300.2" /db_xref="EnsemblGenomes-Gn:BSU24200" /db_xref="EnsemblGenomes-Tr:CAB14351" /db_xref="GOA:P40770" /db_xref="SubtiList:BG11030" /db_xref="UniProtKB/Swiss-Prot:P40770" /translation="MKQTVLLLFTALFLSGCSVASADDSVPRFTEEGKYIGSADPHTI AVSLNGEETMIQVPKDKRDECESLPDQTHVLVKYTKKDNGTLQLEDIQLRKNS*" /label="yqiH CDS" gene complement(2114542..2114835) /gene="yqiH" /locus_tag="BSU_24200" /old_locus_tag="BSU24200" /label="yqiH gene" promotor_-10 complement(2114855..2114874) /Source="Nicolas_upshift_promotors" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2114861) /Source="Nicolas_upshifts" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2114889..2114896) /Source="Nicolas_upshift_promotors" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2115091..2115098 /Source="Nicolas_upshift_promotors" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2115112..2115131 /Source="Nicolas_upshift_promotors" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2115129..2115334 /Source="Nicolas_S_feature" /locus_tag="new_2516201_2516406" /HighExp="Diami, dia15, dia5, H2O2, Paraq, LBGexp, G180, LBGstat, LBGtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99653599999999998" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S911" upshifts 2115129 /Source="Nicolas_upshifts" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="upshifts" CDS 2115143..2115295 /locus_tag="BSU_24205" /old_locus_tag="BSU24205" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513977.1" /translation="MKEVKAMKKFVLLLAAAVITCSIGHQISGGYKGPEKERPKHHSA LKIFSR*" /label="hypothetical protein CDS" gene 2115143..2115295 /locus_tag="BSU_24205" /old_locus_tag="BSU24205" /label="gene" promotor_-35 2115303..2115310 /Source="Nicolas_upshift_promotors" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2115325..2115344 /Source="Nicolas_upshift_promotors" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2115336 /Source="Nicolas_upshifts" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="upshifts" CDS 2115368..2116486 /gene="yqiG" /locus_tag="BSU_24210" /old_locus_tag="BSU24210" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH-dependent flavin oxidoreductase" /protein_id="NP_390301.1" /db_xref="EnsemblGenomes-Gn:BSU24210" /db_xref="EnsemblGenomes-Tr:CAB14352" /db_xref="GOA:P54524" /db_xref="InterPro:IPR001155" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG11716" /db_xref="UniProtKB/Swiss-Prot:P54524" /translation="MNPKYKPLFEPFTFKSGVTINNRIAVAPMTHYASNEDGTISEAE LDYIIPRSKEMGMVITACANVTPDGKAFPGQPAIHDDSNIPGLKKLAQAIQAQGAKAV VQIHHGGIECPSELVPQQDVVGPSDVFDNGKQIARALTEEEVENIVKAFGEATRRAIE AGFDGVEIHGANGYLIQQFYSPKTNQRTDRWGGSDEKRLAFPLAIVDEVKKAASEHAK GAFLVGYRLSPEEPETPGLTMTETYTLVDALGDKELDYLHISLMDVNSKARRGADPTR TRMDLLNERVGNKVPLIAVGSIHSADDALAVIENGIPLVAMGREILVDPNWTVKVKEG REKQIETVIKGTDKEKYHLPEPLWQAIVNTQGWVPYKD*" /label="yqiG CDS" gene 2115368..2116486 /gene="yqiG" /locus_tag="BSU_24210" /old_locus_tag="BSU24210" /label="yqiG gene" downshifts 2116471 /Source="Nicolas_upshifts" /id="D1263" /incds=0 /nref=23 /ntot=181 /MaxReadThrough="1.88324" /MaxDrop="6.67511" /score="30.8551972" /energy="-16.1" /TU="NA" /idTUdmin="U1887" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" S_feature complement(2116513..2116683) /Source="Nicolas_S_feature" /locus_tag="new_2517585_2517755_c" /HighExp="T0.30H, S6, S8, T1.30H, T1.0H, T-0.40H, S7, Salt, T0.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigK" /TUshortPSig="1, 0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S912" downshifts complement(2116556) /Source="Nicolas_upshifts" /id="D1264" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="3.46085" /MaxDrop="2.69939" /score="-5.47428449" /energy="-16.1" /TU="U1889" /idTUdmin="U1890" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2116667..2116682) /Source="Nicolas_upshift_promotors" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2116683) /Source="Nicolas_upshifts" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2116685..2116813) /Source="Nicolas_S_feature" /locus_tag="new_2517757_2517885_c" /HighExp="S6, S8, S7, S5, BT, M9-stat, B36, G180, G135, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S913" promotor_-35 complement(2116694..2116703) /Source="Nicolas_upshift_promotors" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2116812..2116831) /Source="Nicolas_upshift_promotors" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2116835) /Source="Nicolas_upshifts" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2116845..2116853) /Source="Nicolas_upshift_promotors" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2116945) /Source="Nicolas_upshifts" /id="D1265" /incds=0 /nref=199 /ntot=267 /MaxReadThrough="2.54843" /MaxDrop="4.82417" /score="-1.10791055" /energy="-15.5" /TU="NA" /idTUdmin="U1891" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2116951..2117754) /gene="spo0A" /locus_tag="BSU_24220" /old_locus_tag="BSU24220" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8504245, 12406209, 15556029, 15808745, 23569226, 26152584, 27148245, 27501195, 28723971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8504245, 12406209, 15556029, 15808745, 23569226, 26152584, 27148245, 27501195, 28723971; Product type r: regulator" /codon_start=1 /transl_table=11 /product="response regulator, phosphorylated in response to complex YlbF/YmcA/YaaT" /protein_id="NP_390302.1" /db_xref="EnsemblGenomes-Gn:BSU24220" /db_xref="EnsemblGenomes-Tr:CAB14353" /db_xref="GOA:P06534" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR012052" /db_xref="InterPro:IPR014879" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1LQ1" /db_xref="SubtiList:BG10765" /db_xref="UniProtKB/Swiss-Prot:P06534" /translation="MEKIKVCVADDNRELVSLLSEYIEGQEDMEVIGVAYNGQECLSL FKEKDPDVLVLDIIMPHLDGLAVLERLRESDLKKQPNVIMLTAFGQEDVTKKAVDLGA SYFILKPFDMENLVGHIRQVSGNASSVTHRAPSSQSSIIRSSQPEPKKKNLDASITSI IHEIGVPAHIKGYLYLREAISMVYNDIELLGSITKVLYPDIAKKFNTTASRVERAIRH AIEVAWSRGNIDSISSLFGYTVSMTKAKPTNSEFIAMVADKLRLEHKAS*" /label="spo0A CDS" gene complement(2116951..2117754) /gene="spo0A" /locus_tag="BSU_24220" /old_locus_tag="BSU24220" /label="spo0A gene" promotor_-10 complement(2117797..2117815) /Source="Nicolas_upshift_promotors" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2117803) /Source="Nicolas_upshifts" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2117805..2117957) /Source="Nicolas_S_feature" /locus_tag="new_2518877_2519029_c" /HighExp="T1.30H, T3.0H, T2.30H, T2.0H, HiTm, Lbtran, T1.0H, T-0.40H, T0.30H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S914" promotor_-35 complement(2117826..2117834) /Source="Nicolas_upshift_promotors" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2117953..2117972) /Source="Nicolas_upshift_promotors" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2117965) /Source="Nicolas_upshifts" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2117984..2117991) /Source="Nicolas_upshift_promotors" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2118030..2119310) /gene="spoIVB" /locus_tag="BSU_24230" /old_locus_tag="BSU24230" /EC_number="3.4.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12218026, 15292188, 16164552, 16238631, 16818230, 17493131, 17557826" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12218026, 15292188, 16164552, 16238631, 16818230, 17493131, 17557826; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="regulatory membrane-associated serine protease" /protein_id="NP_390303.2" /db_xref="EnsemblGenomes-Gn:BSU24230" /db_xref="EnsemblGenomes-Tr:CAB14354" /db_xref="GOA:P17896" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR008763" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR014219" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG10311" /db_xref="UniProtKB/Swiss-Prot:P17896" /translation="MPDNIRKAVGLILLVSLLSVGLCKPLKEYLLIPTQMRVFETQTQ AIETSLSVNAQTSESSEAFTVKKDPHEIKVTGKKSGESELVYDLAGFPIKKTKVHVLP DLKVIPGGQSIGVKLHSVGVLVVGFHQINTSEGKKSPGETAGIEAGDIIIEMNGQKIE KMNDVAPFIQKAGKTGESLDLLIKRDKQKIKTKLIPEKDEGEGKYRIGLYIRDSAAGI GTMTFYEPKTKKYGALGHVISDMDTKKPIVVENGEIVKSTVTSIEKGTGGNPGEKLAR FSSERKTIGDINRNSPFGIFGTLHQPIQNNISDQALPVAFSTEVKKGPAEILTVIDDD KVEKFDIEIVSTTPQKFPATKGMVLKITDPRLLKETGGIVQGMSGSPIIQNGKVIGAV THVFVNDPTSGYGVHIEWMLSEAGIDIYGKEKAS*" /label="spoIVB CDS" gene complement(2118030..2119310) /gene="spoIVB" /locus_tag="BSU_24230" /old_locus_tag="BSU24230" /label="spoIVB gene" downshifts complement(2118045) /Source="Nicolas_upshifts" /id="D1266" /incds=0 /nref=34 /ntot=51 /MaxReadThrough="1.04939" /MaxDrop="7.80695" /score="49.1812184" /energy="-12.5" /TU="NA" /idTUdmin="U1893" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2119371..2119382) /Source="Nicolas_upshift_promotors" /id="U1893" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=830 /SigmaFactorBS="cattcgttcatcagtatatccaatgtttttcttcatatgaca GTTATAAataagccgtcagaaGGCAAAATTAAAtgatgtagcagcaagtcataaagaa g" /listShort="spoIVB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2119385) /Source="Nicolas_upshifts" /id="U1893" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=830 /SigmaFactorBS="cattcgttcatcagtatatccaatgtttttcttcatatgaca GTTATAAataagccgtcagaaGGCAAAATTAAAtgatgtagcagcaagtcataaagaa g" /listShort="spoIVB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2119397..2119403) /Source="Nicolas_upshift_promotors" /id="U1893" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=830 /SigmaFactorBS="cattcgttcatcagtatatccaatgtttttcttcatatgaca GTTATAAataagccgtcagaaGGCAAAATTAAAtgatgtagcagcaagtcataaagaa g" /listShort="spoIVB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2119485..2121215) /gene="recN" /locus_tag="BSU_24240" /old_locus_tag="BSU24240" /function="16.8: Protect" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:15186413, 15849320, 15948952, 16009134, 16061691, 16385024, 17999999, 20360008, 21517913, 23380520, 24373815" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15186413, 15849320, 15948952, 16009134, 16061691, 16385024, 17999999, 20360008, 21517913, 23380520, 24373815; Product type f : factor" /codon_start=1 /transl_table=11 /product="factor for double strand breaks DNA repair and genetic recombination" /protein_id="NP_390304.2" /db_xref="EnsemblGenomes-Gn:BSU24240" /db_xref="EnsemblGenomes-Tr:CAB14355" /db_xref="GOA:P17894" /db_xref="InterPro:IPR004604" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10310" /db_xref="UniProtKB/Swiss-Prot:P17894" /translation="MLAELSIKNFAIIEELTVSFERGLTVLTGETGAGKSIIIDAISL LVGGRGSSEFVRYGEAKAELEGLFLLESGHPVLGVCAEQGIDVSDEMIVMRRDISTSG KSVCRVNGKLVTIASLREIGRLLLDIHGQHDNQLLMEDENHLQLLDKFAGAEVESALK TYQEGYQRYVKLLKKLKQLSESEQEMAHRLDLIQFQLEEIESAKLELNEDEQLQEERQ QISNFEKIYESLQNAYNALRSEQGGLDWVGMASAQLEDISDINEPLKKMSESVSNSYY LLEDATFQMRNMLDELEFDPERLNYIETRLNEIKQLKRKYGATVEDILEYASKIEEEI DQIENRDSHLQSLKKELDSVGKDVAVEAANVSQIRKTWAKKLADEIHRELKSLYMEKS TFDTEFKVRTASRNEEAPLVNGQPVQLTEQGIDLVKFLISTNTGEPLKSLSKVASGGE LSRVMLAIKSIFSSQQDVTSIIFDEVDTGVSGRVAQAIAEKIHKVSIGSQVLCITHLP QVAAMADTHLYIAKELKDGRTTTRVKPLSKQEKVAEIGRMIAGVEVTDLTKRHAKELL KQADQVKTTG*" /label="recN CDS" gene complement(2119485..2121215) /gene="recN" /locus_tag="BSU_24240" /old_locus_tag="BSU24240" /label="recN gene" downshifts complement(2119500) /Source="Nicolas_upshifts" /id="D1267" /incds=0 /nref=232 /ntot=260 /MaxReadThrough="1.73202" /MaxDrop="6.33427" /score="20.028822" /energy="-12.4" /TU="NA" /idTUdmin="U1895" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2121252..2121701) /gene="argR" /locus_tag="BSU_24250" /old_locus_tag="BSU24250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:180070, 9194709, 9383188, 11305941, 11856827, 17020585, 17576690, 18007040, 18455186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 180070, 9194709, 9383188, 11305941, 11856827, 17020585, 17576690, 18007040, 18455186; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AhrC(ArgR)-arginine)" /protein_id="NP_390305.1" /db_xref="EnsemblGenomes-Gn:BSU24250" /db_xref="EnsemblGenomes-Tr:CAB14356" /db_xref="GOA:P17893" /db_xref="InterPro:IPR001669" /db_xref="InterPro:IPR020899" /db_xref="InterPro:IPR020900" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR036251" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1F9N" /db_xref="PDB:2P5K" /db_xref="PDB:2P5L" /db_xref="PDB:2P5M" /db_xref="SubtiList:BG10309" /db_xref="UniProtKB/Swiss-Prot:P17893" /translation="MNKGQRHIKIREIITSNEIETQDELVDMLKQDGYKVTQATVSRD IKELHLVKVPTNNGSYKYSLPADQRFNPLSKLKRALMDAFVKIDSASHMIVLKTMPGN AQAIGALMDNLDWDEMMGTICGDDTILIICRTPEDTEGVKNRLLELL*" /label="argR CDS" gene complement(2121252..2121701) /gene="argR" /locus_tag="BSU_24250" /old_locus_tag="BSU24250" /label="argR gene" S_feature complement(2121702..2121787) /Source="Nicolas_S_feature" /locus_tag="new_2522774_2522859_c" /HighExp="H2O2, G180, G135, G150, Oxctl, Heat, Paraq, C30, dia15, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.742" /label="S915" CDS complement(2121799..2122644) /gene="yqxC" /locus_tag="BSU_24260" /old_locus_tag="BSU24260" /EC_number="2.1.1.-" /function="9.4: RNA processing" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 22333191, 24809820; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2'-O-ribose RNA methyltransferase" /protein_id="NP_390306.2" /db_xref="EnsemblGenomes-Gn:BSU24260" /db_xref="EnsemblGenomes-Tr:CAB14357" /db_xref="GOA:P19672" /db_xref="InterPro:IPR002877" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR004538" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10308" /db_xref="UniProtKB/Swiss-Prot:P19672" /translation="MTSKKERLDVLLVERGLAETREKAKRAIMAGIVYSNENRLDKPG EKIDRDLPLTVKGNPLRYVSRGGLKLEKALKEFPVSVKDKIMIDIGSSTGGFTDCALQ NGAKQSYAVDVGYNQLAWKLRQDERVVVMERTNFRYATPADFTKGMPEFATIDVSFIS LRLILPVLRTLLVPGSDCMALVKPQFEAGRESVGKKGIVRDPKVHADVLKRMISFSAA EGYICKGLSFSPITGGDGNIEFLLHLHWPGEGQEGQELPEEEIMRVVEEAHKTLKEKK ADVPE*" /label="yqxC CDS" gene complement(2121799..2122644) /gene="yqxC" /locus_tag="BSU_24260" /old_locus_tag="BSU24260" /label="yqxC gene" downshifts complement(2121832) /Source="Nicolas_upshifts" /id="D1268" /incds=0 /nref=1 /ntot=65 /MaxReadThrough="5.65358" /MaxDrop="2.6955" /score="4.97422627" /energy="-9.4" /TU="U1895,U1896,U1898" /idTUdmin="U1895" /TUdmin="-2332" /isTUend="FALSE" /label="downshifts" CDS complement(2122641..2124542) /gene="dxs" /locus_tag="BSU_24270" /old_locus_tag="BSU24270" /EC_number="2.2.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12882400, 15292217, 17458547, 23840410, 25212876; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="1-deoxyxylulose-5-phosphate synthase" /protein_id="NP_390307.1" /db_xref="EnsemblGenomes-Gn:BSU24270" /db_xref="EnsemblGenomes-Tr:CAB14358" /db_xref="GOA:P54523" /db_xref="InterPro:IPR005474" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR005477" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR020826" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG11715" /db_xref="UniProtKB/Swiss-Prot:P54523" /translation="MDLLSIQDPSFLKNMSIDELEKLSDEIRQFLITSLSASGGHIGP NLGVVELTVALHKEFNSPKDKFLWDVGHQSYVHKLLTGRGKEFATLRQYKGLCGFPKR SESEHDVWETGHSSTSLSGAMGMAAARDIKGTDEYIIPIIGDGALTGGMALEALNHIG DEKKDMIVILNDNEMSIAPNVGAIHSMLGRLRTAGKYQWVKDELEYLFKKIPAVGGKL AATAERVKDSLKYMLVSGMFFEELGFTYLGPVDGHSYHELIENLQYAKKTKGPVLLHV ITKKGKGYKPAETDTIGTWHGTGPYKINTGDFVKPKAAAPSWSGLVSGTVQRMAREDG RIVAITPAMPVGSKLEGFAKEFPDRMFDVGIAEQHAATMAAAMAMQGMKPFLAIYSTF LQRAYDQVVHDICRQNANVFIGIDRAGLVGADGETHQGVFDIAFMRHIPNMVLMMPKD ENEGQHMVHTALSYDEGPIAMRFPRGNGLGVKMDEQLKTIPIGTWEVLRPGNDAVILT FGTTIEMAIEAAEELQKEGLSVRVVNARFIKPIDEKMMKSILKEGLPILTIEEAVLEG GFGSSILEFAHDQGEYHTPIDRMGIPDRFIEHGSVTALLEEIGLTKQQVANRIRLLMP PKTHKGIGS*" /label="dxs CDS" gene complement(2122641..2124542) /gene="dxs" /locus_tag="BSU_24270" /old_locus_tag="BSU24270" /label="dxs gene" promotor_-35 2123750..2123756 /Source="Nicolas_upshift_promotors" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2123771..2123782 /Source="Nicolas_upshift_promotors" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2123779 /Source="Nicolas_upshifts" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2124543..2124671) /Source="Nicolas_S_feature" /locus_tag="new_2525615_2525743_c" /HighExp="Salt, Heat, dia15, H2O2, HiOs, Cold, T-5.40H, T3.30H, SMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.742" /label="S916" promotor_-10 complement(2124666..2124685) /Source="Nicolas_upshift_promotors" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2124671) /Source="Nicolas_upshifts" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2124700..2124706) /Source="Nicolas_upshift_promotors" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2124717..2125607) /gene="ispA" /locus_tag="BSU_24280" /old_locus_tag="BSU24280" /EC_number="2.5.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8755734, 12682299, 17147392, 23569278; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="farnesyl diphosphate synthase" /protein_id="NP_390308.2" /db_xref="EnsemblGenomes-Gn:BSU24280" /db_xref="EnsemblGenomes-Tr:CAB14359" /db_xref="GOA:P54383" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR033749" /db_xref="SubtiList:BG11714" /db_xref="UniProtKB/Swiss-Prot:P54383" /translation="MTNKLTSFLADRKKTIENQLSVYTEKLDMPDSLKKSMLYSLQAG GKRLRPLIVLAVLNAYGKSEKDGIPVGCAVEMIHTYSLIHDDLPCMDDDDLRRGKPTN HKVFGEATAVLAGDGLLTESFKLITSHVSDEVSAEKRLRLVNELISAAGTEGMVGGQV ADMEAENRQVTLEELESIHERKTAKLLGFCVIAGAILADAPEEDIETLRTFSSHIGIG FQIRDDILDLEGSEEKIGKRVGSDTTNDKSTYPSLLSLEGAKHKLDVHIKEAKRLIGG LSLQKDLLYELCDLIAARDH*" /label="ispA CDS" gene complement(2124717..2125607) /gene="ispA" /locus_tag="BSU_24280" /old_locus_tag="BSU24280" /label="ispA gene" CDS complement(2125597..2125851) /gene="xseB" /locus_tag="BSU_24290" /old_locus_tag="BSU24290" /EC_number="3.1.11.6" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11381137, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exodeoxyribonuclease VII (small subunit)" /protein_id="NP_390309.2" /db_xref="EnsemblGenomes-Gn:BSU24290" /db_xref="EnsemblGenomes-Tr:CAB14360" /db_xref="GOA:P54522" /db_xref="InterPro:IPR003761" /db_xref="InterPro:IPR037004" /db_xref="SubtiList:BG11713" /db_xref="UniProtKB/Swiss-Prot:P54522" /translation="MTDVKKNENMTFEEAMKGLESIVSKLEEGDVPLEQAINYFQEGM ALSKMCHEKLQKVEKQMDFILKEDGELAPFSVQEEDEGDK*" /label="xseB CDS" gene complement(2125597..2125851) /gene="xseB" /locus_tag="BSU_24290" /old_locus_tag="BSU24290" /label="xseB gene" CDS complement(2125848..2127194) /gene="xseA" /locus_tag="BSU_24300" /old_locus_tag="BSU24300" /EC_number="3.1.11.6" /function="16.9: Replicate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 17182742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exodeoxyribonuclease VII (large subunit)" /protein_id="NP_390310.2" /db_xref="EnsemblGenomes-Gn:BSU24300" /db_xref="EnsemblGenomes-Tr:CAB14361" /db_xref="GOA:P54521" /db_xref="InterPro:IPR003753" /db_xref="InterPro:IPR020579" /db_xref="InterPro:IPR025824" /db_xref="SubtiList:BG11712" /db_xref="UniProtKB/Swiss-Prot:P54521" /translation="MGEAAYVTVSALTKYIKRKFDVDPHLENIWIKGELSNVKIHTRG HIYFTLKDENARMQSVMFARQSERLPFKPENGMKVLVRGGISVYEPSGNYQLYAKEMQ PDGVGALYLAYEELKKKLAGEGLFDDRYKKQIPAFPATIGVVTSPTGAAVRDVITTLK RRYPLVKVIVLPALVQGENASRSIVTRIEEANEKEICDVLIVGRGGGSIEELWAFNEE IVARAIFASNIPIISAVGHETDFTISDFVADIRAATPTGAAEIAVPHTTDLIERTKTA EVRMTRAMQQHLGQKKERIQTLQSSYAFRFPKRLYAQKEQQFDLAYQQFQAQLTALLD RKSRQLERETYRLEALHPHEQLKQARTRYQEQTNQLRKNMNIQMKQLHSQFQTVLGKL NALSPLQVMERGYSLAYKEDKLIKSVSQIEEQDRLEIKLKDGVLTCEVLEKRGEEK*" /label="xseA CDS" gene complement(2125848..2127194) /gene="xseA" /locus_tag="BSU_24300" /old_locus_tag="BSU24300" /label="xseA gene" S_feature complement(2127195..2127331) /Source="Nicolas_S_feature" /locus_tag="new_2528267_2528403_c" /HighExp="H2O2, G180, G135, Cold, G150, Paraq, Oxctl, LBGstat, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigA" /TUshortPSig="0.993, 0.742, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S917" CDS complement(2127332..2128183) /gene="folD" /locus_tag="BSU_24310" /old_locus_tag="BSU24310" /EC_number="1.5.1.5" /EC_number="3.5.4.9" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7061514, 9454603, 12682299, 19171795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylenetetrahydrofolate dehydrogenase; methenyltetrahydrofolate cyclohydrolase" /protein_id="NP_390311.1" /db_xref="EnsemblGenomes-Gn:BSU24310" /db_xref="EnsemblGenomes-Tr:CAB14362" /db_xref="GOA:P54382" /db_xref="InterPro:IPR000672" /db_xref="InterPro:IPR020630" /db_xref="InterPro:IPR020631" /db_xref="InterPro:IPR020867" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11711" /db_xref="UniProtKB/Swiss-Prot:P54382" /translation="MTATIIDGKETAREKREQLAKEVEELKKQGVTPGLAVILIGDDP ASHSYVRGKKKAAETMGMNFKLDQFDSSLTEAELLSIIDQYNQDPEFHGILVQLPLPD HISEKAVIERISPDKDVDGFHPLNVGKMLLGEDTFLPCTPHGIVELLKKTNIDLSGKE VVVVGRSNIVGKPVGQLLLNENATVTYCHSRTENITEHTKKADILVVAVGRANFISAD QIKEGAVVIDVGVNRLENGKLCGDVEFEGAKEKASFITPVPGGVGPMTITMLAHNTVK SAKRTLS*" /label="folD CDS" gene complement(2127332..2128183) /gene="folD" /locus_tag="BSU_24310" /old_locus_tag="BSU24310" /label="folD gene" CDS complement(2128195..2128590) /gene="nusB" /locus_tag="BSU_24320" /old_locus_tag="BSU24320" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16707701, 16946247, 27964882; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription termination factor NusB" /protein_id="NP_390312.2" /db_xref="EnsemblGenomes-Gn:BSU24320" /db_xref="EnsemblGenomes-Tr:CAB14363" /db_xref="GOA:P54520" /db_xref="InterPro:IPR006027" /db_xref="InterPro:IPR011605" /db_xref="InterPro:IPR035926" /db_xref="SubtiList:BG11710" /db_xref="UniProtKB/Swiss-Prot:P54520" /translation="MKRRTAREKALQALFQIDVSDIAVNEAIEHALDEEKTDPFFEQL VHGVLEHQDQLDEMISKHLVNWKLDRIANVDRAILRLAAYEMAYAEDIPVNVSMNEAI ELAKRFGDDKATKFVNGVLSNIKSDIEQS*" /label="nusB CDS" gene complement(2128195..2128590) /gene="nusB" /locus_tag="BSU_24320" /old_locus_tag="BSU24320" /label="nusB gene" misc_feature complement(2128633..2128652) /Source="Nicolas_upshift_promotors" /id="U1896" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.416583416583417" /psig="0.993006993006993" /xcortree=2425 /SigmaFactorBS="tgaaaatattcggtaatagggtaaaaaaaccttgatttcaat atgcggatacgaaaaaaaTATGTTATGATCTCTTTGTGgcttaacgacaagcggataa a" /listShort="nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2128652) /Source="Nicolas_upshifts" /id="U1896" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.416583416583417" /psig="0.993006993006993" /xcortree=2425 /SigmaFactorBS="tgaaaatattcggtaatagggtaaaaaaaccttgatttcaat atgcggatacgaaaaaaaTATGTTATGATCTCTTTGTGgcttaacgacaagcggataa a" /listShort="nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2128654..2128816) /Source="Nicolas_S_feature" /locus_tag="new_2529726_2529888_c" /HighExp="G180, G150, Oxctl, Etha, G135, GM 120, dia0, HPh, MG 150, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.742, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S918" CDS complement(2128854..2129261) /gene="yqhY" /locus_tag="BSU_24330" /old_locus_tag="BSU24330" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 17114254, 22720735, 28579978" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 17114254, 22720735, 28579978; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="alkaline shock protein" /protein_id="NP_390313.2" /db_xref="EnsemblGenomes-Gn:BSU24330" /db_xref="EnsemblGenomes-Tr:CAB14364" /db_xref="InterPro:IPR005531" /db_xref="SubtiList:BG11709" /db_xref="UniProtKB/Swiss-Prot:P54519" /translation="MKDNSLLKMDHEDTHLGKVEIAPEVIEVIAGIAASEVDGVAEMR GNFATGVVERFGKVNHGKGVKVDLADDGITIDVYCVVTFGVSIPKVAASVQENIRQTL LNMTSLSINEINIHIVGIQFDTKAQEVQIDEEM*" /label="yqhY CDS" gene complement(2128854..2129261) /gene="yqhY" /locus_tag="BSU_24330" /old_locus_tag="BSU24330" /label="yqhY gene" downshifts complement(2128861) /Source="Nicolas_upshifts" /id="D1269" /incds=0 /nref=6 /ntot=76 /MaxReadThrough="6.4099" /MaxDrop="4.1473" /score="9.44795832" /energy="-9.5" /TU="U1897,U1898" /idTUdmin="U1899" /TUdmin=2409 /isTUend="FALSE" /label="downshifts" CDS complement(2129282..2130634) /gene="accC" /locus_tag="BSU_24340" /old_locus_tag="BSU24340" /EC_number="6.3.4.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592499, 12682299, 14594796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592499, 12682299, 14594796; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase subunit (biotin carboxylase subunit)" /protein_id="NP_390314.2" /db_xref="EnsemblGenomes-Gn:BSU24340" /db_xref="EnsemblGenomes-Tr:CAB14365" /db_xref="GOA:P49787" /db_xref="InterPro:IPR004549" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG11384" /db_xref="UniProtKB/Swiss-Prot:P49787" /translation="MIKKLLIANRGEIAVRIIRACRELGIETVAVYSEADKDALHVQM ADEAFCIGPKASKDSYLNVTNIVSVAKLTGTDAIHPGYGFLAENADFAELCEEVNVTF VGPSADAISKMGTKDVARETMKQAGVPIVPGSQGIIENVEEAVSLANEIGYPVIIKAT AGGGGKGIRVARTEEELINGIKITQQEAATAFGNPGVYIEKYIEDFRHVEIQVLADNY GNTIHLGERDCSIQRRLQKLLEESPSPALDSEIREQMGDAAVKAAKAVGYTGAGTVEF IYDYNEQRYYFMEMNTRIQVEHPVTEMVTGTDLIKEQIKVASGMELSLKQEDVEFEGW AIECRINAENPSKNFMPSPGEIKMYLPPGGLGVRVDSAAYPGYSIPPYYDSMIAKVIT YGKTRDEAIARMKRALSEFVIEGIETTIPFHLKLLEHETFVSGEFNTKFLETYDVMGS *" /label="accC CDS" gene complement(2129282..2130634) /gene="accC" /locus_tag="BSU_24340" /old_locus_tag="BSU24340" /label="accC gene" promotor_-10 complement(2130163..2130182) /Source="Nicolas_upshift_promotors" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="promotor_-10" upshifts complement(2130170) /Source="Nicolas_upshifts" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="upshifts" promotor_-35 complement(2130197..2130203) /Source="Nicolas_upshift_promotors" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="promotor_-35" CDS complement(2130646..2131125) /gene="accB" /locus_tag="BSU_24350" /old_locus_tag="BSU24350" /EC_number="6.4.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592499, 12682299, 14594796, 15518551" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592499, 12682299, 14594796, 15518551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase subunit (biotin carboxyl carrier subunit)" /protein_id="NP_390315.1" /db_xref="EnsemblGenomes-Gn:BSU24350" /db_xref="EnsemblGenomes-Tr:CAB14366" /db_xref="GOA:P49786" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001249" /db_xref="InterPro:IPR001882" /db_xref="InterPro:IPR011053" /db_xref="SubtiList:BG11383" /db_xref="UniProtKB/Swiss-Prot:P49786" /translation="MLNIKEIHELIKAIDESTIDEFVYENEGVSLKLKKHEAGTVQVM QQAPAAPVQAQAPQAVQPQAQQAAAPAQEAPKQDENLHKITSPMVGTFYASSSPEAGP YVTAGSKVNENTVVCIVEAMKLFNEIEAEVKGEIVEVLVENGQLVEYGQPLFLVKAE* " /label="accB CDS" gene complement(2130646..2131125) /gene="accB" /locus_tag="BSU_24350" /old_locus_tag="BSU24350" /label="accB gene" promotor_-10 complement(2131184..2131203) /Source="Nicolas_upshift_promotors" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2131195) /Source="Nicolas_upshifts" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2131217..2131224) /Source="Nicolas_upshift_promotors" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2131281..2131937) /gene="spoIIIAH" /locus_tag="BSU_24360" /old_locus_tag="BSU24360" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15028710, 15752199, 16959571, 1766372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15028710, 15752199, 16959571, 1766372; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation ratchet engulfment protein" /protein_id="NP_390316.2" /db_xref="EnsemblGenomes-Gn:BSU24360" /db_xref="EnsemblGenomes-Tr:CAB14367" /db_xref="GOA:P49785" /db_xref="InterPro:IPR024232" /db_xref="PDB:3TUF" /db_xref="PDB:3UZ0" /db_xref="SubtiList:BG11415" /db_xref="UniProtKB/Swiss-Prot:P49785" /translation="MLKKQTVWLLTMLSLVVVLSVYYIMSPESKNAVQMQSEKSASDS GEVATEKAPAKQDTKEKSGTETEKGKEDGTKGTKDSSADKETSAEASEKGTVVTETAD DDLFTTYRLDLEDARSKEREELNAIVSSDDATAKEKSEAYDKMTALSEVEGTEKQLET LIKTQGYEDALVNAEGDKINITVKSDKHSKSKATAIIDLVAKEIKTMKDVAVTFEPSK *" /label="spoIIIAH CDS" gene complement(2131281..2131937) /gene="spoIIIAH" /locus_tag="BSU_24360" /old_locus_tag="BSU24360" /label="spoIIIAH gene" downshifts complement(2131288) /Source="Nicolas_upshifts" /id="D1270" /incds=0 /nref=26 /ntot=57 /MaxReadThrough="0.0903599999999987" /MaxDrop="6.40434" /score="21.0450747" /energy="-13" /TU="NA" /idTUdmin="U1899" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" CDS complement(2131938..2132627) /gene="spoIIIAG" /locus_tag="BSU_24370" /old_locus_tag="BSU24370" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation engulfment assembly protein" /protein_id="NP_390317.2" /db_xref="EnsemblGenomes-Gn:BSU24370" /db_xref="EnsemblGenomes-Tr:CAB14368" /db_xref="GOA:P49784" /db_xref="InterPro:IPR014195" /db_xref="SubtiList:BG11414" /db_xref="UniProtKB/Swiss-Prot:P49784" /translation="MNKNGLWNVLKKQFLPGQTKDGEKPKLTKYHYFLFVFVLGVSFM LVSQLFSSPEKTENAKTITAVSSQHSADSKEKTAEVFKASKSDKPKDSIDDYEKEYEN QLKEILETIIGVDDVSVVVNVDATSLKVYEKNKSNKNTTTEETDKEGGKRSVTDQSSE EEIVMIKNGDKETPVVVQTKKPDIRGVLVVAQGVDNVQIKQTIIEAVTRVLDVPSHRV AVAPKKIKEDS*" /label="spoIIIAG CDS" gene complement(2131938..2132627) /gene="spoIIIAG" /locus_tag="BSU_24370" /old_locus_tag="BSU24370" /label="spoIIIAG gene" CDS complement(2132620..2133240) /gene="spoIIIAF" /locus_tag="BSU_24380" /old_locus_tag="BSU24380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390318.1" /db_xref="EnsemblGenomes-Gn:BSU24380" /db_xref="EnsemblGenomes-Tr:CAB14369" /db_xref="GOA:P49783" /db_xref="InterPro:IPR014245" /db_xref="SubtiList:BG11413" /db_xref="UniProtKB/Swiss-Prot:P49783" /translation="MSFLTEWLTTIVLFILFAIVIDMLLPSSSMQKYAKMVVSLLLIV VMLTPIFKLFKTDPEVIFEYLTKNGQSESADIKNQINSKKIEIQASQRAYILEEMAVQ LKKKAEERFSHDEYKVGRIKLTAGEKVDSEEDIKTISVYMAPSSEKTVQTVAPVHIDT DHAYVTKEAAEQKEAKQIQTQLADIWEIGSEKITVHMEGGESVGNE*" /label="spoIIIAF CDS" gene complement(2132620..2133240) /gene="spoIIIAF" /locus_tag="BSU_24380" /old_locus_tag="BSU24380" /label="spoIIIAF gene" promotor_-10 complement(2132946..2132964) /Source="Nicolas_upshift_promotors" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2132964) /Source="Nicolas_upshifts" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2132980..2132985) /Source="Nicolas_upshift_promotors" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2133254..2134453) /gene="spoIIIAE" /locus_tag="BSU_24390" /old_locus_tag="BSU24390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 15849754, 16850406, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 15849754, 16850406, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390319.2" /db_xref="EnsemblGenomes-Gn:BSU24390" /db_xref="EnsemblGenomes-Tr:CAB14370" /db_xref="GOA:P49782" /db_xref="InterPro:IPR014194" /db_xref="SubtiList:BG11412" /db_xref="UniProtKB/Swiss-Prot:P49782" /translation="MKRFQWVLLLAVLIIAGRAEIVQAAGNAEQTEDHAETAEQLAER TAASLETDKIGEFWNDIMTEYGGLLPESQKGSLMEFINGDKSFSPQEWLKALFSYLFH EVLANGKLLGTLILLTIFCVILQLLQNAFQQSTVSKVAYSIVYMVLIILALNSFHVAI NYATEAIQTMTSFILALIPLLLALLASSGGAVSAAFFHPVILFLMNTSGLLIQNIVMP LIFLSAILSIVSTMTEQYKVTQLANLLRNIAIGALAVFLTIFLGVISVQGASAAVTDG ITLRTAKFITGNFIPVLGRMFTDATDTVISASLLLKNTVGILGVAILICIAAFPAIKV LSLAFIYKLAAAILQPLGGGPVITCLDVISKSVIYIFAALAIVSLMFFLSLTVIITAG NLTMMMK*" /label="spoIIIAE CDS" gene complement(2133254..2134453) /gene="spoIIIAE" /locus_tag="BSU_24390" /old_locus_tag="BSU24390" /label="spoIIIAE gene" CDS complement(2134472..2134873) /gene="spoIIIAD" /locus_tag="BSU_24400" /old_locus_tag="BSU24400" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 15849754, 16850406, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 15849754, 16850406, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390320.1" /db_xref="EnsemblGenomes-Gn:BSU24400" /db_xref="EnsemblGenomes-Tr:CAB14371" /db_xref="GOA:P49781" /db_xref="InterPro:IPR014211" /db_xref="InterPro:IPR025664" /db_xref="SubtiList:BG11411" /db_xref="UniProtKB/Swiss-Prot:P49781" /translation="MQIDIVQIVGLGLIATFLSLIVKEQKPTFAFLIVVFAGCAIFLY LVDQIYDIIRMIEKIAINANVNMVYVETILKIIGIAYIAEFGAQLTKDAGQGAIASKI ELAGKILILVMAVPILTVIIETILGLIPSMS*" /label="spoIIIAD CDS" gene complement(2134472..2134873) /gene="spoIIIAD" /locus_tag="BSU_24400" /old_locus_tag="BSU24400" /label="spoIIIAD gene" CDS complement(2134880..2135086) /gene="spoIIIAC" /locus_tag="BSU_24410" /old_locus_tag="BSU24410" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390321.1" /db_xref="EnsemblGenomes-Gn:BSU24410" /db_xref="EnsemblGenomes-Tr:CAB14372" /db_xref="GOA:P49780" /db_xref="InterPro:IPR009570" /db_xref="InterPro:IPR025664" /db_xref="SubtiList:BG11410" /db_xref="UniProtKB/Swiss-Prot:P49780" /translation="MGVDVNVIFQIAGVGIVVAFLHTILDQMGKKEYAQWVTLLGFIY ILFMVATIVDDLFKKIKAVFLFQG*" /label="spoIIIAC CDS" gene complement(2134880..2135086) /gene="spoIIIAC" /locus_tag="BSU_24410" /old_locus_tag="BSU24410" /label="spoIIIAC gene" CDS complement(2135109..2135624) /gene="spoIIIAB" /locus_tag="BSU_24420" /old_locus_tag="BSU24420" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390322.1" /db_xref="EnsemblGenomes-Gn:BSU24420" /db_xref="EnsemblGenomes-Tr:CAB14373" /db_xref="GOA:Q01368" /db_xref="InterPro:IPR014198" /db_xref="SubtiList:BG10541" /db_xref="UniProtKB/Swiss-Prot:Q01368" /translation="MLKLLGAVFIVVATTWTGFEMAKIYTERPRQIRQLRAALQSLEA EIMYGHTPLHTASQQIAKQLAQPVSTLFSAFSDQLDKGSDSAKTAWEQSLKKVWDTLS LKKSEYEVLKQFGETLGIHDRISQQKHIKLALTHLEASEADAEQAQAKNEKMIKSLGF LAGLLLILLLM*" /label="spoIIIAB CDS" gene complement(2135109..2135624) /gene="spoIIIAB" /locus_tag="BSU_24420" /old_locus_tag="BSU24420" /label="spoIIIAB gene" CDS complement(2135618..2136541) /gene="spoIIIAA" /locus_tag="BSU_24430" /old_locus_tag="BSU24430" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="ATP-binding stage III sporulation protein" /protein_id="NP_390323.1" /db_xref="EnsemblGenomes-Gn:BSU24430" /db_xref="EnsemblGenomes-Tr:CAB14374" /db_xref="GOA:Q01367" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR014217" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10540" /db_xref="UniProtKB/Swiss-Prot:Q01367" /translation="MNEIAEVLPESMKNALSEIPEQQWLEIEEVRIRINRPVELIRRG QPVYLSYAGTAEDAHLILSRLSNYSMYTLEEELKKGYVTIRGGHRVGLAGRVITENGG VKGLRDIASFNIRIARQKLGIAEPLLPYLYQNSWLNTLIIGPPQTGKTTLLRDLARLS STGKKNMLPVKTGIVDERSEIAGCLRGIPQHQFGQRIDVLDACPKAEGLMMMIRSMSP EVMIVDEIGRMEDTDALLEALHAGVSVIVSAHGWSISDLMKRPSLKRLWEERAFDRYL ELSRAKGPGTVSQIYDKDGNVLSRTTGVKTC*" /label="spoIIIAA CDS" gene complement(2135618..2136541) /gene="spoIIIAA" /locus_tag="BSU_24430" /old_locus_tag="BSU24430" /label="spoIIIAA gene" S_feature complement(2136542..2136616) /Source="Nicolas_S_feature" /locus_tag="new_2537614_2537688_c" /HighExp="S3, LoTm, S4, T5.0H, M9-stat, S5, BT, S7, S6, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S919" CDS complement(2136617..2136898) /gene="yqhV" /locus_tag="BSU_24440" /old_locus_tag="BSU24440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390324.1" /db_xref="EnsemblGenomes-Gn:BSU24440" /db_xref="EnsemblGenomes-Tr:CAB14375" /db_xref="GOA:P49779" /db_xref="InterPro:IPR020390" /db_xref="SubtiList:BG11459" /db_xref="UniProtKB/Swiss-Prot:P49779" /translation="MKFLLGNINSTVLTMAGLRVLSSMIELTAAIVMLVTNDVRKAVV VNSILAIVGPLIFIITMTVGIYQIAGQLSYAKLILIFTGVVLILAGVHK*" /label="yqhV CDS" gene complement(2136617..2136898) /gene="yqhV" /locus_tag="BSU_24440" /old_locus_tag="BSU24440" /label="yqhV gene" promotor_-10 complement(2136918..2136936) /Source="Nicolas_upshift_promotors" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="promotor_-10" upshifts complement(2136941) /Source="Nicolas_upshifts" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="upshifts" promotor_-35 complement(2136952..2136957) /Source="Nicolas_upshift_promotors" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="promotor_-35" CDS complement(2137043..2137600) /gene="efp" /locus_tag="BSU_24450" /old_locus_tag="BSU24450" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1956781, 14586115, 15066026, 15210970, 16014871, 27002156, 28787546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1956781, 14586115, 15066026, 15210970, 16014871, 27002156, 28787546; Product type f: factor" /codon_start=1 /transl_table=11 /product="elongation factor P" /protein_id="NP_390325.2" /db_xref="EnsemblGenomes-Gn:BSU24450" /db_xref="EnsemblGenomes-Tr:CAB14376" /db_xref="GOA:P49778" /db_xref="InterPro:IPR001059" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR011768" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013185" /db_xref="InterPro:IPR013852" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR015365" /db_xref="InterPro:IPR020599" /db_xref="SubtiList:BG11460" /db_xref="UniProtKB/Swiss-Prot:P49778" /translation="MISVNDFRTGLTIEVDGGIWRVVDFQHVKPGKGAAFVRSKLRNL RTGAIQEKTFRAGEKVAKAQIETKTMQYLYANGDQHVFMDTSSYEQLELSATQIEEEL KYLLENMSVHIMMYQDETLGIELPNTVELKVVETEPGIKGDTASGGTKPAKTETGLVV NVPFFVNEGDTLVVNTSDGSYVSRA*" /label="efp CDS" gene complement(2137043..2137600) /gene="efp" /locus_tag="BSU_24450" /old_locus_tag="BSU24450" /label="efp gene" downshifts complement(2137055) /Source="Nicolas_upshifts" /id="D1271" /incds=0 /nref=256 /ntot=266 /MaxReadThrough="0.83852" /MaxDrop="7.73118" /score="27.4193827" /energy="-13.5" /TU="NA" /idTUdmin="U1901" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2137625..2138686) /gene="papA" /locus_tag="BSU_24460" /old_locus_tag="BSU24460" /EC_number="3.4.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:23144141, 26735940, 27002156" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23144141, 26735940, 27002156; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminopeptidase (Met-Xaa and Xaa-Pro, Xaa-Pro-Xaa)" /protein_id="NP_390326.1" /db_xref="EnsemblGenomes-Gn:BSU24460" /db_xref="EnsemblGenomes-Tr:CAB14377" /db_xref="GOA:P54518" /db_xref="InterPro:IPR000587" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001131" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR029149" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG11708" /db_xref="UniProtKB/Swiss-Prot:P54518" /translation="MKLEKLRNLFGQLGIDGMLITSNTNVRYMTGFTGSAGLAVISGD KAAFITDFRYTEQAKVQVKGFEIIEHGGSLIQTTADTVESFGIKRLGFEQNSMTYGTY ASYSAVISDAELVPVAESVEKLRLIKSSEEIKILEEAAKIADDAFRHILTFMKPGISE IAVANELEFYMRSQGADSSSFDMIVASGLRSSLPHGVASDKLIESGDLVTLDFGAYYK GYCSDITRTVAVGQPSDQLKEIYQVVFDAQALGVAHIKPGMTGKEADALTRDHIAAKG YGDYFGHSTGHGLGMEVHESPGLSVRSSAILEPGMVVTVEPGIYIPETGGVRIEDDIV ITENGNRTITHSPKELIIL*" /label="papA CDS" gene complement(2137625..2138686) /gene="papA" /locus_tag="BSU_24460" /old_locus_tag="BSU24460" /label="papA gene" CDS complement(2138683..2139129) /gene="yqhS" /locus_tag="BSU_24470" /old_locus_tag="BSU24470" /EC_number="4.2.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10870960, 19099550; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate dehydratase, type II" /protein_id="NP_390327.1" /db_xref="EnsemblGenomes-Gn:BSU24470" /db_xref="EnsemblGenomes-Tr:CAB14378" /db_xref="GOA:P54517" /db_xref="InterPro:IPR001874" /db_xref="InterPro:IPR018509" /db_xref="InterPro:IPR036441" /db_xref="PDB:1GQO" /db_xref="SubtiList:BG11707" /db_xref="UniProtKB/Swiss-Prot:P54517" /translation="MPHFLILNGPNVNRLGSREPEVFGRQTLTDIETDLFQFAEALHI QLTFFQSNHEGDLIDAIHEAEEQYSGIVLNPGALSHYSYAIRDAVSSISLPVVEVHLS NLYAREEFRHQSVIAPVAKGQIVGLGAEGYKLAVRYLLSQQGGESR*" /label="yqhS CDS" gene complement(2138683..2139129) /gene="yqhS" /locus_tag="BSU_24470" /old_locus_tag="BSU24470" /label="yqhS gene" promotor_-10 complement(2139178..2139197) /Source="Nicolas_upshift_promotors" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2139194) /Source="Nicolas_upshifts" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2139210..2139217) /Source="Nicolas_upshift_promotors" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2139216..2139752) /gene="yqhR" /locus_tag="BSU_24480" /old_locus_tag="BSU24480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390328.1" /db_xref="EnsemblGenomes-Gn:BSU24480" /db_xref="EnsemblGenomes-Tr:CAB14379" /db_xref="GOA:P54516" /db_xref="InterPro:IPR024563" /db_xref="SubtiList:BG11706" /db_xref="UniProtKB/Swiss-Prot:P54516" /translation="MMTSEKDTEQNEELNEKQKPPVSMAGRVAATGFCGGVLWSFVAY IAYLFHFSEISPNMILQPFVLGEWKKHGLGTVISIILIGVISIGAAFLYFLLLKRLKT MWPGILYGLVLWLLVFFVFNPIFPDVRTVTELTSDTIITTICIYLLYGLFVGYSISFE YNELNSEKLARALGMHRE*" /label="yqhR CDS" gene complement(2139216..2139752) /gene="yqhR" /locus_tag="BSU_24480" /old_locus_tag="BSU24480" /label="yqhR gene" promotor_-10 complement(2139765..2139776) /Source="Nicolas_upshift_promotors" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="promotor_-10" upshifts complement(2139774) /Source="Nicolas_upshifts" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="upshifts" promotor_-35 complement(2139790..2139796) /Source="Nicolas_upshift_promotors" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="promotor_-35" promotor_-35 2139822..2139828 /Source="Nicolas_upshift_promotors" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2139841 /Source="Nicolas_upshifts" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2139843..2139861 /Source="Nicolas_upshift_promotors" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2139898..2139901 /Source="Nicolas_upshift_promotors" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2139916..2139935 /Source="Nicolas_upshift_promotors" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2139927 /Source="Nicolas_upshifts" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="upshifts" CDS 2139979..2140935 /gene="yqhQ" /locus_tag="BSU_24490" /old_locus_tag="BSU24490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390329.2" /db_xref="EnsemblGenomes-Gn:BSU24490" /db_xref="EnsemblGenomes-Tr:CAB14380" /db_xref="GOA:P54515" /db_xref="InterPro:IPR010787" /db_xref="SubtiList:BG11705" /db_xref="UniProtKB/Swiss-Prot:P54515" /translation="MSKHKVPPAYGGQAVVEGVMFGGKHHYVTAIRRTDGSIDFFKLP RKHNPKLNIVKKIPFLRGIAAIIEASANGTKHLNFSSERYGLDPSEDETLEQEEKKSS GLSMYLSLAVIGVLSFLFSKFVFTLVPVFLAELTRPIFSLNTAQIAIESLFKLILLLG YIYFLSMTPLIKRVFQYHGAEHKVINCYEQNLPITVENVQNQSRLHYRCGSSFILFTI IVGMFVYLLVPTDPLWLRVIDRVALIPVVLGISFEVLQLTNKVRDIPGLKLLGYPGLW LQLLTTKEPKDEQVEVAIESFNELLRLEALSEQNQKPSHNVI*" /label="yqhQ CDS" gene 2139979..2140935 /gene="yqhQ" /locus_tag="BSU_24490" /old_locus_tag="BSU24490" /label="yqhQ gene" CDS 2140975..2141370 /gene="yqhP" /locus_tag="BSU_24500" /old_locus_tag="BSU24500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390330.1" /db_xref="EnsemblGenomes-Gn:BSU24500" /db_xref="EnsemblGenomes-Tr:CAB14381" /db_xref="GOA:P54514" /db_xref="SubtiList:BG11704" /db_xref="UniProtKB/Swiss-Prot:P54514" /translation="MNHRVQPIIAVLIALGAFGFLYVLVTNPGEMAKMAVTVIVAGII IYFIVKYVMNRNAGSEGAAFKKAAKQSRRRMKEQKAKHRAGHKGRVSHLRSVPSASKP KPMILKKKSQTQLTVIEGKKNKKKNRALF*" /label="yqhP CDS" gene 2140975..2141370 /gene="yqhP" /locus_tag="BSU_24500" /old_locus_tag="BSU24500" /label="yqhP gene" promotor_no_box 2141253..2141353 /Source="Nicolas_upshift_promotors" /id="U1905" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.578421578421578" /psig="0.007992007992008" /xcortree=275 /SigmaFactorBS="gcgaagcgttccgagcgccagcaagcctaagccgatgattct caagaaaaaaagccagactcagctgactgttatagaagggaaaaaaaataaaaagaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2141313 /Source="Nicolas_upshifts" /id="U1905" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.578421578421578" /psig="0.007992007992008" /xcortree=275 /SigmaFactorBS="gcgaagcgttccgagcgccagcaagcctaagccgatgattct caagaaaaaaagccagactcagctgactgttatagaagggaaaaaaaataaaaagaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2141356 /Source="Nicolas_upshifts" /id="D1272" /incds=0 /nref=116 /ntot=283 /MaxReadThrough="2.23161" /MaxDrop="5.94415" /score="29.0609078" /energy="-8" /TU="NA" /idTUdmin="U1903" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2141367..2142242) /gene="yqhO" /locus_tag="BSU_24510" /old_locus_tag="BSU24510" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lipase / acyl esterase" /protein_id="NP_390331.1" /db_xref="EnsemblGenomes-Gn:BSU24510" /db_xref="EnsemblGenomes-Tr:CAB14382" /db_xref="GOA:P54513" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG11703" /db_xref="UniProtKB/Swiss-Prot:P54513" /translation="MYIDGVFSGGGVKGIALAGAYEVLEEKGFRFKRVAGTSAGAIIA AFIASGYTSKEIHALIEEVDGEKLLDQRYSFLPLKMLQWVSIYWRLGLYKGDTIEKWI ADLLRAKGIRVFGDLQKGSLRLIASDLTNGTMIVLPDDLARYGLNPDMFPVARAVRMS CSIPYFFEPIKLKTDTGTATVVDGGVLSNFPIWLFSKERKRPVIGVTLAPRERERPKK NIRNAFELFGALFETMKDAHDARHIASRYEQNIIFLPVDDVMATDFHLTQQKKLALIE LGKRRTELFLKQWTY*" /label="yqhO CDS" gene complement(2141367..2142242) /gene="yqhO" /locus_tag="BSU_24510" /old_locus_tag="BSU24510" /label="yqhO gene" promotor_-10 complement(2142269..2142287) /Source="Nicolas_upshift_promotors" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2142286) /Source="Nicolas_upshifts" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2142303..2142308) /Source="Nicolas_upshift_promotors" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2142368..2142796) /gene="mntR" /locus_tag="BSU_24520" /old_locus_tag="BSU24520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12950915, 15948947, 16533030, 17118401, 17176058, 17342524, 27748968, 28223356" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12950915, 15948947, 16533030, 17118401, 17176058, 17342524, 27748968, 28223356; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (hydrogen peroxide sensing, allosterically regulated by Mn2+)" /protein_id="NP_390332.2" /db_xref="EnsemblGenomes-Gn:BSU24520" /db_xref="EnsemblGenomes-Tr:CAB14383" /db_xref="GOA:P54512" /db_xref="InterPro:IPR001367" /db_xref="InterPro:IPR022687" /db_xref="InterPro:IPR022689" /db_xref="InterPro:IPR022897" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036421" /db_xref="PDB:1ON1" /db_xref="PDB:1ON2" /db_xref="PDB:2EV0" /db_xref="PDB:2EV5" /db_xref="PDB:2EV6" /db_xref="PDB:2F5C" /db_xref="PDB:2F5D" /db_xref="PDB:2F5E" /db_xref="PDB:2F5F" /db_xref="PDB:2HYF" /db_xref="PDB:2HYG" /db_xref="PDB:3R60" /db_xref="PDB:3R61" /db_xref="PDB:4HV5" /db_xref="PDB:4HV6" /db_xref="PDB:4HX4" /db_xref="PDB:4HX7" /db_xref="PDB:4HX8" /db_xref="SubtiList:BG11702" /db_xref="UniProtKB/Swiss-Prot:P54512" /translation="MTTPSMEDYIEQIYMLIEEKGYARVSDIAEALAVHPSSVTKMVQ KLDKDEYLIYEKYRGLVLTSKGKKIGKRLVYRHELLEQFLRIIGVDEEKIYNDVEGIE HHLSWNSIDRIGDLVQYFEEDDARKKDLKSIQKKTEHHNQ*" /label="mntR CDS" gene complement(2142368..2142796) /gene="mntR" /locus_tag="BSU_24520" /old_locus_tag="BSU24520" /label="mntR gene" downshifts complement(2142395) /Source="Nicolas_upshifts" /id="D1273" /incds=0 /nref=322 /ntot=333 /MaxReadThrough="2.568" /MaxDrop="7.28707" /score="15.888362" /energy="-12" /TU="NA" /idTUdmin="U1908" /TUdmin=6 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2142831..2142850) /Source="Nicolas_upshift_promotors" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2142839) /Source="Nicolas_upshifts" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2142866..2142870) /Source="Nicolas_upshift_promotors" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2142896..2143732) /gene="lipM" /locus_tag="BSU_24530" /old_locus_tag="BSU24530" /EC_number="2.3.1.181" /function="3: Fatty acid and phospholipid metabolism" /experiment="publication(s) with functional evidences, PMID:20882995, 21338420, 21338421, 23960015" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20882995, 21338420, 21338421, 23960015; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein octanoyltransferase" /protein_id="NP_390333.1" /db_xref="EnsemblGenomes-Gn:BSU24530" /db_xref="EnsemblGenomes-Tr:CAB14384" /db_xref="GOA:P54511" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR024898" /db_xref="SubtiList:BG11701" /db_xref="UniProtKB/Swiss-Prot:P54511" /translation="MQKETWRFIDSGNASPAFNMALDEALLYWHSEKKIPPVIRFYGW NPATLSVGYFQNIKKEINFEAVHKYNLGFVRRPTGGRGVLHDQELTYSVIVSEEHPEM PATVTEAYRVISEGILQGFRNLGLDAYFAIPRTEKEKESLKNPRSSVCFDAPSWYELV VEGRKVAGSAQTRQKGVILQHGSILLDLDEDKLFDLFLYPSERVRERMQRNFKNKAVA INELIEKRVTMDEARKAFKEGFETGLNIHLEPYELSQEELDFVHHLAETKYASDEWNY KR*" /label="lipM CDS" gene complement(2142896..2143732) /gene="lipM" /locus_tag="BSU_24530" /old_locus_tag="BSU24530" /label="lipM gene" promotor_-10 complement(2143756..2143775) /Source="Nicolas_upshift_promotors" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2143767) /Source="Nicolas_upshifts" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2143769..2144313) /Source="Nicolas_S_feature" /locus_tag="new_2544841_2545385_c" /HighExp="Lbstat, LPhT, HiOs, M0t90, S1, M40t90, Sw, S0, B36, BC" /AntisenseName="yqhL" /AntisenseCor="-0.136624541005539" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S920" promotor_-35 complement(2143789..2143796) /Source="Nicolas_upshift_promotors" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2143813..2143818 /Source="Nicolas_upshift_promotors" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2143832..2143851 /Source="Nicolas_upshift_promotors" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2143832 /Source="Nicolas_upshifts" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="upshifts" S_feature 2143843..2143922 /Source="Nicolas_S_feature" /locus_tag="new_2544915_2544994" /HighExp="dia15, H2O2, dia5, Diami, MG-0.2, G180, UNK1, LBGexp, Heat, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S921" CDS 2143923..2144303 /gene="yqhL" /locus_tag="BSU_24540" /old_locus_tag="BSU24540" /function="5.5: Sulfur metabolism" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11092948; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur transferase" /protein_id="NP_390334.2" /db_xref="EnsemblGenomes-Gn:BSU24540" /db_xref="EnsemblGenomes-Tr:CAB14385" /db_xref="GOA:P54510" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG11700" /db_xref="UniProtKB/Swiss-Prot:P54510" /translation="MSNMIVLIIFAAFIIYMIASYVYQQRIMKTLTEEEFRAGYRKAQ LIDVREPNEFEGGHILGARNIPLSQLKQRKNEIRTDKPVYLYCQNSVRSGRAAQTLRK NGCTEIYNLKGGFKKWGGKIKAKK*" /label="yqhL CDS" gene 2143923..2144303 /gene="yqhL" /locus_tag="BSU_24540" /old_locus_tag="BSU24540" /label="yqhL gene" downshifts 2144239 /Source="Nicolas_upshifts" /id="D1274" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.17088" /MaxDrop="3.92673" /score="27.1863605" /energy="-12" /TU="U1909" /idTUdmin="U1909" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 2144283 /Source="Nicolas_upshifts" /id="D1275" /incds=0 /nref=213 /ntot=249 /MaxReadThrough="2.26861" /MaxDrop="6.03848" /score="27.1863605" /energy="-12" /TU="NA" /idTUdmin="U1909" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2144338..2145804) /gene="gcvPB" /locus_tag="BSU_24550" /old_locus_tag="BSU24550" /EC_number="1.4.4.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8181752, 20011599, 22720735, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8181752, 20011599, 22720735, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine decarboxylase (subunit 2) (glycine cleavage system protein P)" /protein_id="NP_390335.1" /db_xref="EnsemblGenomes-Gn:BSU24550" /db_xref="EnsemblGenomes-Tr:CAB14386" /db_xref="GOA:P54377" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020581" /db_xref="InterPro:IPR023012" /db_xref="SubtiList:BG11511" /db_xref="UniProtKB/Swiss-Prot:P54377" /translation="MSNQDQALIFELSREGRIGYSLPELDVPEIELGDLLSDTYIRDE DAALPEVSELDIMRHYTALSKRNHGVDSGFYPLGSCTMKYNPKINEKIARIPGFAAIH PLQDEDTVQGALELLYDLSKHLEEITGMDEVTLQPAAGAHGEWTGLMMIRAYHEARGD FKRTKVIVPDSAHGTNPASATVAGFETVTVKSNEKGLVDLEDLKRAVNEETAALMLTN PNTLGLFEEQITEMAEIVHQAGGKLYYDGANLNAVLSKARPGDMGFDVVHLNLHKTFT GPHGGGGPGSGPVGVKQDLIPYLPKPVLVKKEGRFTFDYDRPHAIGRVKPYYGNFGIN VRAYTYIRSMGPDGLKAVTENAVLNANYMMRKLAPYYDLPFDRHCKHEFVLSGKRQKK LGVRTLDIAKRLLDFGYHPPTIYFPLNVEECIMIEPTETESKETLDAFIDAMIQIAKE AEENPELVQEAPHTTIVKRMDETKAARHPVLRYEAEER*" /label="gcvPB CDS" gene complement(2144338..2145804) /gene="gcvPB" /locus_tag="BSU_24550" /old_locus_tag="BSU24550" /label="gcvPB gene" downshifts complement(2144358) /Source="Nicolas_upshifts" /id="D1276" /incds=0 /nref=31 /ntot=215 /MaxReadThrough="3.45831" /MaxDrop="4.3142" /score="0.884126414" /energy="-12" /TU="U1911" /idTUdmin="U1911" /TUdmin="-1517" /isTUend="FALSE" /label="downshifts" CDS complement(2145797..2147143) /gene="gcvPA" /locus_tag="BSU_24560" /old_locus_tag="BSU24560" /EC_number="1.4.4.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8181752, 20011599, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine decarboxylase (subunit 1) (glycine cleavage system protein P)" /protein_id="NP_390336.2" /db_xref="EnsemblGenomes-Gn:BSU24560" /db_xref="EnsemblGenomes-Tr:CAB14387" /db_xref="GOA:P54376" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020581" /db_xref="InterPro:IPR023010" /db_xref="SubtiList:BG11510" /db_xref="UniProtKB/Swiss-Prot:P54376" /translation="MKHRYLPATEKDKQEMLATIGVSSIDDLFADIPENVKYKKEHQI KKAKSETELTRELTKLASKNRDTVQYASFLGAGVYDHYQPVIVDHVISRSEFYTAYTP YQPEISQGELQAIFEFQTMICELTGMDIANSSMYDGGTALAEAAMLASGHTKKKKIVV SKTVHPESREVLKTYAKGQYIDVVEVPAADGVTDLDALRQTVCENTAAVIVQYPNFFG RIEPLKDIEPIAHQGKSMFIVSANPLALGLLTPPGKFQSDIVVGDAQPFGIPSAYGGP HCGFFAVTKKLMRKVPGRLVGQTEDENGKRGFVLTLQAREQHIRRDKATSNICSNQAL NALAASVAMTALGKNGVKDIARQNLLKANYAKQEAKKAGLTVMFDGPMFNEFVIKLDE PVRAVNKRLLAKGMIGGYDLGLTYPELDCHMLIAVTELRTKEEIDALIQELGDRHE*" /label="gcvPA CDS" gene complement(2145797..2147143) /gene="gcvPA" /locus_tag="BSU_24560" /old_locus_tag="BSU24560" /label="gcvPA gene" CDS complement(2147173..2148261) /gene="gcvT" /locus_tag="BSU_24570" /old_locus_tag="BSU24570" /EC_number="2.1.2.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8219277, 15472076, 22720735, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8219277, 15472076, 22720735, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminomethyltransferase (glycine cleavage system protein T)" /protein_id="NP_390337.2" /db_xref="EnsemblGenomes-Gn:BSU24570" /db_xref="EnsemblGenomes-Tr:CAB14388" /db_xref="GOA:P54378" /db_xref="InterPro:IPR006222" /db_xref="InterPro:IPR006223" /db_xref="InterPro:IPR013977" /db_xref="InterPro:IPR022903" /db_xref="InterPro:IPR028896" /db_xref="InterPro:IPR029043" /db_xref="PDB:1YX2" /db_xref="SubtiList:BG11509" /db_xref="UniProtKB/Swiss-Prot:P54378" /translation="MLKRTPLFDLYKEYGGKTIDFGGWELPVQFSSIKKEHEAVRTAA GLFDVSHMGEVEVSGNDSLSFLQRLMTNDVSALTPGRAQYTAMCYPDGGTVDDLLIYQ KGENRYLLVINASNIDKDLAWMKEHAAGDVQIDNQSDQIALLAVQGPKAEAILKNLTD ADVSALKPFAFIDEADISGRKALISRTGYTGEDGYEIYCRSDDAMHIWKKIIDAGDAY GLIPCGLGARDTLRFEAKLPLYGQELTRDITPIEAGIGFAVKHKKESDFFGKSVLSEQ KENGAKRKLVGLEMIEKGIPRHGYEVFQNGKSVGKVTTGTQSPTLGKNVGLALIDSET SEIGTVVDVEIRKKLVKAKVVKTPFYKR*" /label="gcvT CDS" gene complement(2147173..2148261) /gene="gcvT" /locus_tag="BSU_24570" /old_locus_tag="BSU24570" /label="gcvT gene" misc_RNA complement(2148335..2148534) /gene="swgA" /locus_tag="BSU_misc_RNA_37" /product="dual aptamer glycine riboswitch" /experiment="publication(s) with functional evidences, PMID:15472076, 21439473, 23249744, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15472076, 21439473, 23249744, 23721735, 29089431; Product type n: RNA" /label="swgA RNA" gene complement(2148335..2148534) /gene="swgA" /locus_tag="BSU_misc_RNA_37" /label="swgA gene" downshifts complement(2148385) /Source="Nicolas_upshifts" /id="D1277" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="6.79606" /MaxDrop="3.0322" /score="21.5485037" /energy="-20.2" /TU="U1911" /idTUdmin="U1915" /TUdmin=3630 /isTUend="FALSE" /label="downshifts" S_feature complement(2148535..2148605) /Source="Nicolas_S_feature" /locus_tag="new_2549607_2549677_c" /HighExp="B60, S8, S6, B36, S7, M9-stat, Sw, T3.0H, HiOs, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S922" promotor_-35 2148538..2148543 /Source="Nicolas_upshift_promotors" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2148559..2148577 /Source="Nicolas_upshift_promotors" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2148563 /Source="Nicolas_upshifts" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="upshifts" S_feature 2148573..2148702 /Source="Nicolas_S_feature" /locus_tag="new_2549645_2549774" /HighExp="S4, S8, S7, S3, S5, S6, LoTm, T5.0H, T4.0H, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.83" /TUlongSig="NA" /TUlongPSig="NA" /label="S923" promotor_-10 complement(2148591..2148610) /Source="Nicolas_upshift_promotors" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="promotor_-10" upshifts complement(2148605) /Source="Nicolas_upshifts" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="upshifts" promotor_-35 complement(2148624..2148631) /Source="Nicolas_upshift_promotors" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="promotor_-35" CDS 2148703..2150376 /gene="yqhH" /locus_tag="BSU_24580" /old_locus_tag="BSU24580" /EC_number="3.6.-.-" /function="16.3: Control" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA polymerase-associated helicase protein" /protein_id="NP_390338.1" /db_xref="EnsemblGenomes-Gn:BSU24580" /db_xref="EnsemblGenomes-Tr:CAB14389" /db_xref="GOA:P54509" /db_xref="InterPro:IPR000330" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11699" /db_xref="UniProtKB/Swiss-Prot:P54509" /translation="MNTEMIYDAKWPEEFAERLKNDGPWANWELYKLSAEIQKTLAIP EFEGLRAPLYLPSFTPLPHQLEVAQKVVEKMNGKAILADEVGLGKTVEAGLILKEYMI RGLAKKILILVPASLVSQWVKELQEKFLIPAVEQKKSYVWEQCDIVVSSIDTAKRSPH REIVLSIPYDLVIIDEAHKLKNSKTKNYEFVRNLVKKYCLLLTATPIQNRIEEIFNLV SLLKPGHLGSQNHFQEEFAKKKSSLEAHEHLKDLVNKVMIRNRRHDTGLNWKQRHVET VPIQFSPSEQALYDEISRLKDSINKPASMFSIMTLQRECCSSREAVYMTLKKMLDQKE KQAPAIDEDTISVLIDRINQVTQNSKALQVVDLIKKIDDKVIIFTEYRATQIYLQWFL QQNGISSVPFRGGFKRGKKDWMKDLFRGKIQVLIATEAGGEGINLQFCNHMINYDLPW NPMRLEQRIGRIHRLGQERDVHIYNMATKHTVEEHILKLLYEKIHLFEKVVGELDDIL TKIQVNNFEEHLHDILYHSATEEEMKIKMDNLTSFLSYKKQLPAEKRGS*" /label="yqhH CDS" gene 2148703..2150376 /gene="yqhH" /locus_tag="BSU_24580" /old_locus_tag="BSU24580" /label="yqhH gene" CDS 2150397..2151191 /gene="yqhG" /locus_tag="BSU_24590" /old_locus_tag="BSU24590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390339.1" /db_xref="EnsemblGenomes-Gn:BSU24590" /db_xref="EnsemblGenomes-Tr:CAB14390" /db_xref="InterPro:IPR024562" /db_xref="SubtiList:BG11698" /db_xref="UniProtKB/Swiss-Prot:P54508" /translation="MRQQEVHDFLLRFFQANSCQIVDQGLGYMTVQLTVEMDKQIMNR PFYWHWREKTGGDPNPMKITFITDKENAPKDLDGEFIYFGAPRLFQIFKAVKQNGRFT RMYEKIESAGAKVPLQPWLGINVTISYQSDMKKDKLLSLGLHLVSGTIIEDFQSKLTQ FSLTSQICDYCFTISPMIKPESGLKRMENYISKSAMQEPSDWAEQAVNRWKNDMTLLD KFYEHIEEKPEEYHLEKQALKTLYQPKISVEIENGGLFYLQNNISS*" /label="yqhG CDS" gene 2150397..2151191 /gene="yqhG" /locus_tag="BSU_24590" /old_locus_tag="BSU24590" /label="yqhG gene" misc_feature 2150727..2150728 /Source="Nicolas_upshift_promotors" /id="U1912" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.497502497502497" /psig="0.541458541458541" /xcortree=3205 /SigmaFactorBS="aaagctgttaaacaaaatgggagatttaccagaatgtatgag aaaattgaatcaGCcggagctaaagtcccacttcagccttggcttggtataaatgtca c" /GFF_Attribute="listShort" /listLong="S924, sinI, sinR" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2150733 /Source="Nicolas_upshifts" /id="U1912" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.497502497502497" /psig="0.541458541458541" /xcortree=3205 /SigmaFactorBS="aaagctgttaaacaaaatgggagatttaccagaatgtatgag aaaattgaatcaGCcggagctaaagtcccacttcagccttggcttggtataaatgtca c" /GFF_Attribute="listShort" /listLong="S924, sinI, sinR" /label="upshifts" promotor_-35 2151215..2151218 /Source="Nicolas_upshift_promotors" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2151234..2151253 /Source="Nicolas_upshift_promotors" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2151235..2151373 /Source="Nicolas_S_feature" /locus_tag="new_2552307_2552445" /HighExp="LoTm, S4, S5, T5.0H, M9-stat, S3, B60, S7, T4.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.843, 0.83" /TUlongSig="SigA" /TUlongPSig="0.541" /label="S924" upshifts 2151235 /Source="Nicolas_upshifts" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="upshifts" CDS 2151374..2151547 /gene="sinI" /locus_tag="BSU_24600" /old_locus_tag="BSU24600" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8549812, 10547280, 11751836, 15661000, 15805512, 23569226, 25326308, 26434553, 28430084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8549812, 10547280, 11751836, 15661000, 15805512, 23569226, 25326308, 26434553, 28430084; Product type r: regulator" /codon_start=1 /transl_table=11 /product="antagonist of SinR" /protein_id="NP_390340.1" /db_xref="EnsemblGenomes-Gn:BSU24600" /db_xref="EnsemblGenomes-Tr:CAB14391" /db_xref="GOA:P23308" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR036281" /db_xref="PDB:1B0N" /db_xref="SubtiList:BG10753" /db_xref="UniProtKB/Swiss-Prot:P23308" /translation="MKNAKQEHFELDQEWVELMVEAKEANISPEEIRKYLLLNKKSAH PGPAARSHTVNPF*" /label="sinI CDS" gene 2151374..2151547 /gene="sinI" /locus_tag="BSU_24600" /old_locus_tag="BSU24600" /label="sinI gene" promotor_-35 2151532..2151536 /Source="Nicolas_upshift_promotors" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2151549..2151568 /Source="Nicolas_upshift_promotors" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2151549 /Source="Nicolas_upshifts" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="upshifts" CDS 2151581..2151916 /gene="sinR" /locus_tag="BSU_24610" /old_locus_tag="BSU24610" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15805512, 16585769, 16740951, 16923912, 21708175, 25326308, 26434553, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15805512, 16585769, 16740951, 16923912, 21708175, 25326308, 26434553, 28546427; Product type r: regulator" /codon_start=1 /transl_table=11 /product="master regulator of biofilm formation" /protein_id="NP_390341.1" /db_xref="EnsemblGenomes-Gn:BSU24610" /db_xref="EnsemblGenomes-Tr:CAB14392" /db_xref="GOA:P06533" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR036281" /db_xref="PDB:1B0N" /db_xref="PDB:2YAL" /db_xref="PDB:3QQ6" /db_xref="PDB:3ZKC" /db_xref="SubtiList:BG10754" /db_xref="UniProtKB/Swiss-Prot:P06533" /translation="MIGQRIKQYRKEKGYSLSELAEKAGVAKSYLSSIERNLQTNPSI QFLEKVSAVLDVSVHTLLDEKHETEYDGQLDSEWEKLVRDAMTSGVSKKQFREFLDYQ KWRKSQKEE*" /label="sinR CDS" gene 2151581..2151916 /gene="sinR" /locus_tag="BSU_24610" /old_locus_tag="BSU24610" /label="sinR gene" downshifts 2151893 /Source="Nicolas_upshifts" /id="D1278" /incds=0 /nref=21 /ntot=181 /MaxReadThrough="4.7611" /MaxDrop="6.41889" /score="2.30357781" /energy="-20" /TU="U1913,U1914" /idTUdmin="U1910" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" downshifts 2151983 /Source="Nicolas_upshifts" /id="D1279" /incds=0 /nref=1 /ntot=85 /MaxReadThrough="2.4376" /MaxDrop="4.25363" /score="58.1462301" /energy="-26.8" /TU="NA" /idTUdmin="U1913" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(2152009..2152794) /gene="tasA" /locus_tag="BSU_24620" /old_locus_tag="BSU24620" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10464223, 10827084, 16430695, 16430696, 18047568, 23569226, 25326308, 27655338, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464223, 10827084, 16430695, 16430696, 18047568, 23569226, 25326308, 27655338, 28546427; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="major biofilm matrix component" /protein_id="NP_390342.1" /db_xref="EnsemblGenomes-Gn:BSU24620" /db_xref="EnsemblGenomes-Tr:CAB14393" /db_xref="GOA:P54507" /db_xref="InterPro:IPR022121" /db_xref="InterPro:IPR023833" /db_xref="SubtiList:BG11697" /db_xref="UniProtKB/Swiss-Prot:P54507" /translation="MGMKKKLSLGVASAALGLALVGGGTWAAFNDIKSKDATFASGTL DLSAKENSASVNLSNLKPGDKLTKDFQFENNGSLAIKEVLMALNYGDFKANGGSNTSP EDFLSQFEVTLLTVGKEGGNGYPKNIILDDANLKDLYLMSAKNDAAAAEKIKKQIDPK FLNASGKVNVATIDGKTAPEYDGVPKTPTDFDQVQMEIQFKDDKTKDEKGLMVQNKYQ GNSIKLQFSFEATQWNGLTIKKDHTDKDGYVKENEKAHSEDKN*" /label="tasA CDS" gene complement(2152009..2152794) /gene="tasA" /locus_tag="BSU_24620" /old_locus_tag="BSU24620" /label="tasA gene" downshifts complement(2152015) /Source="Nicolas_upshifts" /id="D1280" /incds=0 /nref=144 /ntot=227 /MaxReadThrough="4.33009" /MaxDrop="8.70948" /score="10.0483516" /energy="-20" /TU="NA" /idTUdmin="U1915" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(2152847..2152864) /Source="Nicolas_upshift_promotors" /id="U1915" /multdbtbs="-" /comp="M14" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.478521478521479" /xcortree=2768 /SigmaFactorBS="agaaagacaaaagccttggaaacagatacaaaggacagcacc atgtcTACTTAACTTCAGTTGTAaacctggcaacaggtttcgatataaaatcattcaa t" /listShort="tasA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2152851) /Source="Nicolas_upshifts" /id="U1915" /multdbtbs="-" /comp="M14" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.478521478521479" /xcortree=2768 /SigmaFactorBS="agaaagacaaaagccttggaaacagatacaaaggacagcacc atgtcTACTTAACTTCAGTTGTAaacctggcaacaggtttcgatataaaatcattcaa t" /listShort="tasA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2152858..2153430) /gene="sipW" /locus_tag="BSU_24630" /old_locus_tag="BSU24630" /EC_number="3.4.21.89" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10464223, 10559173, 10827084, 15101989, 16430695, 22328672, 26346121, 27655338" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464223, 10559173, 10827084, 15101989, 16430695, 22328672, 26346121, 27655338; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_390343.1" /db_xref="EnsemblGenomes-Gn:BSU24630" /db_xref="EnsemblGenomes-Tr:CAB14394" /db_xref="GOA:P54506" /db_xref="InterPro:IPR001733" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG11696" /db_xref="UniProtKB/Swiss-Prot:P54506" /translation="MKLISNILYVIIFTLIIVLTLVVISTRSSGGEPAVFGYTLKSVL SGSMEPEFNTGSLILVKEITDVKELQKGDVITFMQDANTAVTHRIVDITKQGDHLLFK TKGDNNAAADSAPVSDENVRAQYTGFQLPYAGYMLHFASQPIGTAVLLIVPGVMLLVY AFVTISSAIREIERKTKALETDTKDSTMST*" /label="sipW CDS" gene complement(2152858..2153430) /gene="sipW" /locus_tag="BSU_24630" /old_locus_tag="BSU24630" /label="sipW gene" CDS complement(2153414..2154175) /gene="tapA" /locus_tag="BSU_24640" /old_locus_tag="BSU24640" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10464223, 10559173, 14707086, 16430695, 17554552, 21477127, 24488317, 26441856, 26819068, 27655338" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464223, 10559173, 14707086, 16430695, 17554552, 21477127, 24488317, 26441856, 26819068, 27655338; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein for biofilm formation" /protein_id="NP_390344.1" /db_xref="EnsemblGenomes-Gn:BSU24640" /db_xref="EnsemblGenomes-Tr:CAB14395" /db_xref="GOA:P40949" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR023833" /db_xref="InterPro:IPR023848" /db_xref="SubtiList:BG11076" /db_xref="UniProtKB/Swiss-Prot:P40949" /translation="MFRLFHNQQKAKTKLKVLLIFQLSVIFSLTAAICLQFSDDTSAA FHDIETFDVSLQTCKDFQHTDKNCHYDKRWDQSDLHISDQTDTKGTVCSPFALFAVLE NTGEKLKKSKWKWELHKLENARKPLKDGNVIEKGFVSNQIGDSLYKIETKKKMKPGIY AFKVYKPAGYPANGSTFEWSEPMRLAKCDEKPTVPKKETKSDVKKENETTQKDIPEKT MKEETSQEAVTKEKETQSDQKESGEEDEKSNEADQ*" /label="tapA CDS" gene complement(2153414..2154175) /gene="tapA" /locus_tag="BSU_24640" /old_locus_tag="BSU24640" /label="tapA gene" promotor_-10 complement(2154235..2154254) /Source="Nicolas_upshift_promotors" /id="U1916" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.97002997002997" /xcortree=2769 /SigmaFactorBS="aaaacattcttttaaacgaacaaaatgagcgatttcggTGTT TTTAaatctataaatcgTTGATTATACTCTATTTGTGaagttctttaaagagaacgat t" /listShort="yqxM, sipW" /listLong="tasA" /label="promotor_-10" upshifts complement(2154253) /Source="Nicolas_upshifts" /id="U1916" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.97002997002997" /xcortree=2769 /SigmaFactorBS="aaaacattcttttaaacgaacaaaatgagcgatttcggTGTT TTTAaatctataaatcgTTGATTATACTCTATTTGTGaagttctttaaagagaacgat t" /listShort="yqxM, sipW" /listLong="tasA" /label="upshifts" promotor_-35 complement(2154268..2154275) /Source="Nicolas_upshift_promotors" /id="U1916" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.97002997002997" /xcortree=2769 /SigmaFactorBS="aaaacattcttttaaacgaacaaaatgagcgatttcggTGTT TTTAaatctataaatcgTTGATTATACTCTATTTGTGaagttctttaaagagaacgat t" /listShort="yqxM, sipW" /listLong="tasA" /label="promotor_-35" promotor_-35 2154397..2154403 /Source="Nicolas_upshift_promotors" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2154404 /Source="Nicolas_upshifts" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2154417..2154428 /Source="Nicolas_upshift_promotors" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2154447..2154773 /gene="yqzG" /locus_tag="BSU_24650" /old_locus_tag="BSU24650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_390345.1" /db_xref="EnsemblGenomes-Gn:BSU24650" /db_xref="EnsemblGenomes-Tr:CAB14396" /db_xref="InterPro:IPR024987" /db_xref="PDB:2LYX" /db_xref="SubtiList:BG13773" /db_xref="UniProtKB/Swiss-Prot:O32019" /translation="MMIKQCVICLSLLVFGTTAAHAEETPLVTARHMSKWEEIAVKEA KKRYPLAQVLFKQKVWDRKRKDEAVKQYHLTLREGSKEFGVFVTISFDPYSQKVNKIA ILEEYQ*" /label="yqzG CDS" gene 2154447..2154773 /gene="yqzG" /locus_tag="BSU_24650" /old_locus_tag="BSU24650" /label="yqzG gene" S_feature complement(2154590..2154814) /Source="Nicolas_S_feature" /locus_tag="new_2555662_2555886_c" /HighExp="GM 150, G/S, C30, T-4.40H, S8, T-3.40H, Pyr, S7, S2, C90" /AntisenseName="yqzG" /AntisenseCor="0.536702817178903" /AntisenseRegPval="-20.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.549, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S925" downshifts complement(2154633) /Source="Nicolas_upshifts" /id="D1281" /incds=1 /nref=92 /ntot=160 /MaxReadThrough="2.23218" /MaxDrop="5.56661" /score="31.27773" /energy="-10.2" /TU="NA" /idTUdmin="U1918" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 2154755 /Source="Nicolas_upshifts" /id="D1282" /incds=0 /nref=13 /ntot=41 /MaxReadThrough="2.14107" /MaxDrop="4.98052" /score="-9.62570043" /energy="-15.1" /TU="NA" /idTUdmin="U1917" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2154815..2154994) /gene="spoIIT" /locus_tag="BSU_24660" /old_locus_tag="BSU24660" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26735940; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="factor involved in sporulation" /protein_id="NP_390346.2" /db_xref="EnsemblGenomes-Gn:BSU24660" /db_xref="EnsemblGenomes-Tr:CAB14397" /db_xref="InterPro:IPR025622" /db_xref="SubtiList:BG13771" /db_xref="UniProtKB/Swiss-Prot:O32020" /translation="MKTNDYVKYMTQQFVKYIDTPRDERKERKEVRKETKTPVSQQWF GILPYGFRLWLKRKK*" /label="spoIIT CDS" gene complement(2154815..2154994) /gene="spoIIT" /locus_tag="BSU_24660" /old_locus_tag="BSU24660" /label="spoIIT gene" promotor_-10 complement(2155013..2155031) /Source="Nicolas_upshift_promotors" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2155028) /Source="Nicolas_upshifts" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2155046..2155052) /Source="Nicolas_upshift_promotors" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2155065..2155439) /gene="comGG" /locus_tag="BSU_24670" /old_locus_tag="BSU24670" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 16850406, 24164455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 16850406, 24164455; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390347.1" /db_xref="EnsemblGenomes-Gn:BSU24670" /db_xref="EnsemblGenomes-Tr:CAB14398" /db_xref="GOA:P25959" /db_xref="InterPro:IPR020372" /db_xref="SubtiList:BG10489" /db_xref="UniProtKB/Swiss-Prot:P25959" /translation="MYRTRGFIYPAVLFVSALVLLIVNFVAAQYISRCMFEKETKELY IGENLLQNGVLLSIRHVLEERKGQEGTQQFLYGRVSYYIHDTSIKEQKEINLRVSTDS GTERTAQIVFDQKQKKLLRWTE*" /label="comGG CDS" gene complement(2155065..2155439) /gene="comGG" /locus_tag="BSU_24670" /old_locus_tag="BSU24670" /label="comGG gene" CDS complement(2155440..2155823) /gene="comGF" /locus_tag="BSU_24680" /old_locus_tag="BSU24680" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 16850406; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390348.1" /db_xref="EnsemblGenomes-Gn:BSU24680" /db_xref="EnsemblGenomes-Tr:CAB14399" /db_xref="GOA:P25958" /db_xref="InterPro:IPR016977" /db_xref="SubtiList:BG10488" /db_xref="UniProtKB/Swiss-Prot:P25958" /translation="MLISGSLAAIIHLFLSRQQEHDGFTQQEWMISIEQMMNECKESQ AVKTAEHGSVLICTNLSGQDIRFDIYHSMIRKRVDGKGHVPILDHITAMKADIENGVV LLKIESEDQKVYQTAFPVYSYLGGG*" /label="comGF CDS" gene complement(2155440..2155823) /gene="comGF" /locus_tag="BSU_24680" /old_locus_tag="BSU24680" /label="comGF gene" CDS complement(2155849..2156196) /gene="comGE" /locus_tag="BSU_24690" /old_locus_tag="BSU24690" /function="16.11: Scavenge (Catabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7783624, 9224890, 9422590, 9723928, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783624, 9224890, 9422590, 9723928, 16751195; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390349.1" /db_xref="EnsemblGenomes-Gn:BSU24690" /db_xref="EnsemblGenomes-Tr:CAB14400" /db_xref="GOA:P25957" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR020488" /db_xref="SubtiList:BG10487" /db_xref="UniProtKB/Swiss-Prot:P25957" /translation="MWRENKGFSTIETMSALSLWLFVLLTVVPLWDKLMADEKMAESR EIGYQMMNESISKYVMSGEGAASKTITKNNHIYAMKWEEEGEYQNVCIKAAAYKEKSF CLSILQTEWLHAS*" /label="comGE CDS" gene complement(2155849..2156196) /gene="comGE" /locus_tag="BSU_24690" /old_locus_tag="BSU24690" /label="comGE gene" CDS complement(2156180..2156611) /gene="comGD" /locus_tag="BSU_24700" /old_locus_tag="BSU24700" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9224890, 9422590, 9723928, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9224890, 9422590, 9723928, 16751195; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="membrane component of the DNA transport pilin platform" /protein_id="NP_390350.1" /db_xref="EnsemblGenomes-Gn:BSU24700" /db_xref="EnsemblGenomes-Tr:CAB14401" /db_xref="GOA:P25956" /db_xref="InterPro:IPR002416" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR016785" /db_xref="SubtiList:BG10486" /db_xref="UniProtKB/Swiss-Prot:P25956" /translation="MNIKLNEEKGFTLLESLLVLSLASILLVAVFTTLPPAYDNTAVR QAASQLKNDIMLTQQTAISRQQRTKILFHKKEYQLVIGDTVIERPYATGLSIELLTLK DRLEFNEKGHPNAGGKIRVKGHAVYDITVYLGSGRVNVERK*" /label="comGD CDS" gene complement(2156180..2156611) /gene="comGD" /locus_tag="BSU_24700" /old_locus_tag="BSU24700" /label="comGD gene" CDS complement(2156601..2156897) /gene="comGC" /locus_tag="BSU_24710" /old_locus_tag="BSU24710" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7783624, 9723928, 11744713, 16751195, 22820325, 24164455, 28659339" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783624, 9723928, 11744713, 16751195, 22820325, 24164455, 28659339; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="pilin-like component of the DNA transport membrane pilin platform" /protein_id="NP_390351.1" /db_xref="EnsemblGenomes-Gn:BSU24710" /db_xref="EnsemblGenomes-Tr:CAB14402" /db_xref="GOA:P25955" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR016940" /db_xref="SubtiList:BG10485" /db_xref="UniProtKB/Swiss-Prot:P25955" /translation="MNEKGFTLVEMLIVLFIISILLLITIPNVTKHNQTIQKKGCEGL QNMVKAQMTAFELDHEGQTPSLADLQSEGYVKKDAVCPNGKRIIITGGEVKVEH*" /label="comGC CDS" gene complement(2156601..2156897) /gene="comGC" /locus_tag="BSU_24710" /old_locus_tag="BSU24710" /label="comGC gene" CDS complement(2156911..2157882) /gene="comGB" /locus_tag="BSU_24720" /old_locus_tag="BSU24720" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 15968048, 16850406, 24164455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 15968048, 16850406, 24164455; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="membrane pilin platform component of the DNA transport machinery" /protein_id="NP_390352.1" /db_xref="EnsemblGenomes-Gn:BSU24720" /db_xref="EnsemblGenomes-Tr:CAB14403" /db_xref="GOA:P25954" /db_xref="InterPro:IPR001992" /db_xref="InterPro:IPR018076" /db_xref="SubtiList:BG10484" /db_xref="UniProtKB/Swiss-Prot:P25954" /translation="MTAGGYTLLDGLRLMELQMNKRQAADLTDSVTCLREGAPFYQVL KSLSFHKEAVGICYFAETHGELPASMIQSGELLERKIAQADQLKRVLRYPLFLIFTVA VMFYMLQSIIIPQFSGIYQSMNMETSRSTDMLFAFFQHIDLVIILLVLFTAGIGIYYW LVFKKKSPARQMLICIRIPLVGKLVKLFNSYFFSLQLSSLLKSGLSIYDSLNAFKHQT FLPFYRCEAEQLIERLKAGESIESAICGSLFYETDLSKVISHGQLSGRLDRELFTYSQ FILQRLEHKAQKWTGILQPMIYGFVAAMILLVYLSMLVPMYQMMNQM*" /label="comGB CDS" gene complement(2156911..2157882) /gene="comGB" /locus_tag="BSU_24720" /old_locus_tag="BSU24720" /label="comGB gene" CDS complement(2157935..2159005) /gene="comGA" /locus_tag="BSU_24730" /old_locus_tag="BSU24730" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11298275, 15528548, 16009134, 9723928, 21564336, 21707789, 25899641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11298275, 15528548, 16009134, 9723928, 21564336, 21707789, 25899641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane associated ATPase of the pilin platformfor DNA competence" /protein_id="NP_390353.1" /db_xref="EnsemblGenomes-Gn:BSU24730" /db_xref="EnsemblGenomes-Tr:CAB14404" /db_xref="GOA:P25953" /db_xref="InterPro:IPR001482" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10483" /db_xref="UniProtKB/Swiss-Prot:P25953" /translation="MDSIEKVSKNLIEEAYLTKASDIHIVPRERDAIIHFRVDHALLK KRDMKKEECVRLISHFKFLSAMDIGERRKPQNGSLTLKLKEGNVHLRMSTLPTINEES LVIRVMPQYNIPSIDKLSLFPKTGATLLSFLKHSHGMLIFTGPTGSGKTTTLYSLVQY AKKHFNRNIVTLEDPVETRDEDVLQVQVNEKAGVTYSAGLKAILRHDPDMIILGEIRD AETAEIAVRAAMTGHLVLTSLHTRDAKGAIYRLLEFGINMNEIEQTVIAIAAQRLVDL ACPFCENGCSSVYCRQSRNTRRASVYELLYGKNLQQCIQEAKGNHANYQYQTLRQIIR KGIALGYLTTNNYDRWVYHEKD*" /label="comGA CDS" gene complement(2157935..2159005) /gene="comGA" /locus_tag="BSU_24730" /old_locus_tag="BSU24730" /label="comGA gene" promotor_-10 complement(2159023..2159042) /Source="Nicolas_upshift_promotors" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2159039) /Source="Nicolas_upshifts" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2159056..2159063) /Source="Nicolas_upshift_promotors" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2159188..2159416) /Source="Nicolas_S_feature" /locus_tag="new_2560260_2560488_c" /HighExp="Etha, Salt, Sw, Gly, LPhT, B36, Heat, B60, LoTm, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37350499999999998" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S926" downshifts complement(2159229) /Source="Nicolas_upshifts" /id="D1283" /incds=0 /nref=16 /ntot=42 /MaxReadThrough="0.95925" /MaxDrop="5.92871" /score="30.7083619" /energy="-13" /TU="NA" /idTUdmin="U1920" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2159417..2160370) /gene="yqxL" /locus_tag="BSU_24740" /old_locus_tag="BSU24740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15856219, 24415722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15856219, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="CorA-type divalent ion transporter" /protein_id="NP_390354.1" /db_xref="EnsemblGenomes-Gn:BSU24740" /db_xref="EnsemblGenomes-Tr:CAB14405" /db_xref="GOA:P40948" /db_xref="InterPro:IPR002523" /db_xref="SubtiList:BG11075" /db_xref="UniProtKB/Swiss-Prot:P40948" /translation="MKAHTGKDWFWYQMGPQERSKARDLIHFSHWPQCEKWFENNHHV NFLRVDTTETENEAVFGSIVYDQGLGEEKDHTVFHFYITRQYFFTINFDFSILREIKG KEVVRQMERADNAIEGFLILLGELMNAYLIGVDEFEVKLRKLRWQIKDDNSKSILNRV HLLRHELMIWKNLILSAKKIEMALKETFLPQNEGKKDYQRTQLKIDRGFTYISEFEGE LNNLLHSEEVITSHRGNEIVKALTIFTTLFTPITALGALWGMNFSVMPELNWKYGYLF SLLLIVTSTVLIYLYLRKKGWTGDMLQERKKKKKPRKRRTL*" /label="yqxL CDS" gene complement(2159417..2160370) /gene="yqxL" /locus_tag="BSU_24740" /old_locus_tag="BSU24740" /label="yqxL gene" promotor_-10 complement(2160394..2160413) /Source="Nicolas_upshift_promotors" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2160415) /Source="Nicolas_upshifts" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2160427..2160433) /Source="Nicolas_upshift_promotors" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2160453..2160459 /Source="Nicolas_upshift_promotors" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2160474..2160492 /Source="Nicolas_upshift_promotors" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2160492 /Source="Nicolas_upshifts" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="upshifts" CDS 2160513..2161841 /gene="yqhB" /locus_tag="BSU_24750" /old_locus_tag="BSU24750" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane associated enzyme" /protein_id="NP_390355.1" /db_xref="EnsemblGenomes-Gn:BSU24750" /db_xref="EnsemblGenomes-Tr:CAB14406" /db_xref="GOA:P54505" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG11695" /db_xref="UniProtKB/Swiss-Prot:P54505" /translation="MPSLEKAVVLEFINLLAVAILILLTGFFVAVEFSIVKVRRSKID QLVAKGKKGAKAAKHVITHLDEYLSACQLGITVAALGLGWLGEPTVQTLLRPLFHKAG LNESLTHLLSLVIAFLVVTYLNVVIGELAPKSFAIQKAESITLLFAKPLIWFYKIMFP FIWLLNHSARLITGVFGLKPASEHELAYTEEELRVLLAESYKSGEIRKSELKYMNNIF TFDKRMAKEIMVPRNEMVSLSLDEDSISNLQETVKQTKYTRYPVVREDKDNVIGVINM KEVLFSMLTKDFSIKKHQIEPFVQPVIHVIETIPIYKLLLKMQKERTHMAILIDEYGG TSGLVTVEDIIEEIVGEIRDEFDADEVPHIRELGKDHYLLNAKLLISDVNSLLGTDLS EAEVDTLGGWFLTQNIDAEPESAIEYDGYSFKVKDINSHHILFIEVKKAE*" /label="yqhB CDS" gene 2160513..2161841 /gene="yqhB" /locus_tag="BSU_24750" /old_locus_tag="BSU24750" /label="yqhB gene" S_feature 2161842..2162816 /Source="Nicolas_S_feature" /locus_tag="new_2562914_2563888" /HighExp="Sw, Salt, Etha, LPhT, M9-stat, S8, BC, S6, BT, Gly" /AntisenseName="rsbRD" /AntisenseCor="0.58358076577781004" /AntisenseRegPval="-25.2" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S927" CDS complement(2161894..2162730) /gene="rsbRD" /locus_tag="BSU_24760" /old_locus_tag="BSU24760" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11157946, 15312768, 15583165, 16963570, 17158665" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11157946, 15312768, 15583165, 16963570, 17158665; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome)" /protein_id="NP_390356.2" /db_xref="EnsemblGenomes-Gn:BSU24760" /db_xref="EnsemblGenomes-Tr:CAB14407" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR025751" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11694" /db_xref="UniProtKB/Swiss-Prot:P54504" /translation="MIALDQHLTEHKKDITQQWLEVCTSNGSWLYSAKDQQKLEQKLK DQHELLVTIVAKSLRKEDVEDELNRWSLQCARDRAVHEVTVTQSVGQFNTFRHIMFEW IHKFSEASSQDISIQEFYEWSRILNQNIDEIIEVFTEEYHQVTMIQLNAQKEMINELS APIMPITDGIGILPLVGEIDTHRARTILESVLEQCSALKLSYLFLDISGVPIVDTMVA YQIFKVIDSTKLLGIETIISGIRPEIAQTVVKLGLDFSNVKTEQSLAKALANKGFKIK EC*" /label="rsbRD CDS" gene complement(2161894..2162730) /gene="rsbRD" /locus_tag="BSU_24760" /old_locus_tag="BSU24760" /label="rsbRD gene" S_feature complement(2162731..2162915) /Source="Nicolas_S_feature" /locus_tag="new_2563803_2563987_c" /HighExp="Etha, LoTm, Salt, Heat, Gly, M9-stat, B60, S8, S0, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.147982" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S928" tRNA 2162817..2162887 /gene="trnSL-Gln1" /locus_tag="BSU_tRNA_73" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln (UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /label="trnSL-Gln1 tRNA" gene 2162817..2162887 /gene="trnSL-Gln1" /locus_tag="BSU_tRNA_73" /label="trnSL-Gln1 gene" CDS complement(2162954..2163334) /gene="mgsR" /locus_tag="BSU_24770" /old_locus_tag="BSU24770" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:18643936, 22812682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18643936, 22812682; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of stress" /protein_id="NP_390357.2" /db_xref="EnsemblGenomes-Gn:BSU24770" /db_xref="EnsemblGenomes-Tr:CAB14408" /db_xref="GOA:P54503" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11693" /db_xref="UniProtKB/Swiss-Prot:P54503" /translation="MEQQLTFYSYPSCTSCRKTKHWLKAHQIEFNERHLFRETPTREE LKYILSLTTEGIDEILATRSQTFKNLNLNIEEMTVNEVLELLIEKPKLLRRPILVDNK KLVIGYNPGELLKLSKKKTVHQSA*" /label="mgsR CDS" gene complement(2162954..2163334) /gene="mgsR" /locus_tag="BSU_24770" /old_locus_tag="BSU24770" /label="mgsR gene" downshifts complement(2162960) /Source="Nicolas_upshifts" /id="D1284" /incds=0 /nref=9 /ntot=174 /MaxReadThrough="6.12556" /MaxDrop="6.72616" /score="0.164931099" /energy="-19.7" /TU="U1922" /idTUdmin="U1925" /TUdmin=912 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2163363..2163381) /Source="Nicolas_upshift_promotors" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2163382) /Source="Nicolas_upshifts" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2163396..2163402) /Source="Nicolas_upshift_promotors" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2163421..2163426 /Source="Nicolas_upshift_promotors" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="promotor_-35" promotor_-10 2163442..2163460 /Source="Nicolas_upshift_promotors" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="promotor_-10" upshifts 2163451 /Source="Nicolas_upshifts" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="upshifts" promotor_-35 2163501..2163508 /Source="Nicolas_upshift_promotors" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="promotor_-35" upshifts 2163523 /Source="Nicolas_upshifts" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="upshifts" promotor_-10 2163524..2163543 /Source="Nicolas_upshift_promotors" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="promotor_-10" CDS 2163566..2163811 /gene="yqgY" /locus_tag="BSU_24780" /old_locus_tag="BSU24780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390358.1" /db_xref="EnsemblGenomes-Gn:BSU24780" /db_xref="EnsemblGenomes-Tr:CAB14409" /db_xref="GOA:P54502" /db_xref="InterPro:IPR020254" /db_xref="SubtiList:BG11692" /db_xref="UniProtKB/Swiss-Prot:P54502" /translation="MNRMFRVLGFWTGIFAVMFYLGDMKDASLLFFGQTILFVFLSYL NLTERMYIYIFGAYLTIFFAGFTYYSIFIMVPGGGGH*" /label="yqgY CDS" gene 2163566..2163811 /gene="yqgY" /locus_tag="BSU_24780" /old_locus_tag="BSU24780" /label="yqgY gene" downshifts 2163708 /Source="Nicolas_upshifts" /id="D1285" /incds=1 /nref=1 /ntot=86 /MaxReadThrough="6.68961" /MaxDrop="2.1025" /score="22.3415753" /energy="-13.7" /TU="U1924" /idTUdmin="U1923" /TUdmin=176 /isTUend="FALSE" /label="downshifts" downshifts 2163797 /Source="Nicolas_upshifts" /id="D1286" /incds=0 /nref=98 /ntot=234 /MaxReadThrough="4.03872" /MaxDrop="5.76938" /score="22.3415753" /energy="-13.7" /TU="U1924" /idTUdmin="U1923" /TUdmin=265 /isTUend="FALSE" /label="downshifts" S_feature 2163842..2164597 /Source="Nicolas_S_feature" /locus_tag="new_2564914_2565669" /HighExp="M9-stat, T0.30H, T1.30H, LoTm, T1.0H, B60, T2.0H, S5, S4, T2.30H" /AntisenseName="yqgX" /AntisenseCor="-0.68109878166952498" /AntisenseRegPval="-37.299999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S929" CDS complement(2163851..2164486) /gene="yqgX" /locus_tag="BSU_24790" /old_locus_tag="BSU24790" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20669241, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-binding hydrolase" /protein_id="NP_390359.1" /db_xref="EnsemblGenomes-Gn:BSU24790" /db_xref="EnsemblGenomes-Tr:CAB14410" /db_xref="GOA:P54501" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11691" /db_xref="UniProtKB/Swiss-Prot:P54501" /translation="MKWRRMPVGPIQANAYFLISDDQCLIFDPGGEGHKINQYIKEKG LTPLAILLTHAHFDHIGALDEVREKWDIPVYLHQNEKNWLADASLNGSGMLRGIEVTA KPADHLIEGDGELNIGPFHLETLFTPGHSPGSVSYYVKDADLVISGDVLFQGGIGRTD LIGGNQETLLTSIHEKLLTLPEHTLVLSGHGPETDVLTEQDQNPFLNGFSL*" /label="yqgX CDS" gene complement(2163851..2164486) /gene="yqgX" /locus_tag="BSU_24790" /old_locus_tag="BSU24790" /label="yqgX gene" downshifts complement(2163876) /Source="Nicolas_upshifts" /id="D1287" /incds=0 /nref=154 /ntot=239 /MaxReadThrough="1.42757" /MaxDrop="5.15622" /score="-8.36666809" /energy="-13.7" /TU="NA" /idTUdmin="U1925" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2164508..2164527) /Source="Nicolas_upshift_promotors" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2164525) /Source="Nicolas_upshifts" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2164541..2164548) /Source="Nicolas_upshift_promotors" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2164565..2164572 /Source="Nicolas_upshift_promotors" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2164587..2164606 /Source="Nicolas_upshift_promotors" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2164599 /Source="Nicolas_upshifts" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2164619) /Source="Nicolas_upshifts" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2164621..2164635) /Source="Nicolas_upshift_promotors" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2164643..2164647) /Source="Nicolas_upshift_promotors" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2164643..2164816 /gene="yqgW" /locus_tag="BSU_24800" /old_locus_tag="BSU24800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390360.1" /db_xref="EnsemblGenomes-Gn:BSU24800" /db_xref="EnsemblGenomes-Tr:CAB14411" /db_xref="GOA:P54500" /db_xref="InterPro:IPR024490" /db_xref="SubtiList:BG11690" /db_xref="UniProtKB/Swiss-Prot:P54500" /translation="MLLVVIFGLVALFALWGVLRSVRNKNILGFLLAGATLFVFGWFT VMTVINSGYPTAH*" /label="yqgW CDS" gene 2164643..2164816 /gene="yqgW" /locus_tag="BSU_24800" /old_locus_tag="BSU24800" /label="yqgW gene" downshifts 2164804 /Source="Nicolas_upshifts" /id="D1288" /incds=0 /nref=255 /ntot=278 /MaxReadThrough="3.92092" /MaxDrop="7.18555" /score="14.1643615" /energy="-12.4" /TU="U1926" /idTUdmin="U1924" /TUdmin=217 /isTUend="FALSE" /label="downshifts" CDS complement(2164848..2165162) /gene="yqgV" /locus_tag="BSU_24810" /old_locus_tag="BSU24810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390361.2" /db_xref="EnsemblGenomes-Gn:BSU24810" /db_xref="EnsemblGenomes-Tr:CAB14412" /db_xref="GOA:P54499" /db_xref="InterPro:IPR002767" /db_xref="InterPro:IPR029756" /db_xref="SubtiList:BG11689" /db_xref="UniProtKB/Swiss-Prot:P54499" /translation="MAIADVTIIPIGTETPSVSAYVADVQKILEGYQAEGKIKYQLTP MNTLIEGELSDLFAVIQAIHEAPFQKGLHRVATNIRIDDRRDKKTTLESKIESVNKHL QP*" /label="yqgV CDS" gene complement(2164848..2165162) /gene="yqgV" /locus_tag="BSU_24810" /old_locus_tag="BSU24810" /label="yqgV gene" S_feature 2164849..2165916 /Source="Nicolas_S_feature" /locus_tag="new_2565921_2566988" /HighExp="LoTm, M9-stat, C30, Cold, S8, S7, B60, Lbstat, G135, C90" /AntisenseName="yqgV" /AntisenseCor="-0.23995763414552801" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigEF" /TUlongPSig="1, 1" /label="S930" downshifts complement(2164862) /Source="Nicolas_upshifts" /id="D1289" /incds=0 /nref=247 /ntot=265 /MaxReadThrough="2.24429" /MaxDrop="6.85096" /score="0.185625845" /energy="-12.4" /TU="NA" /idTUdmin="U1928" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2165165..2166226) /gene="yqgU" /locus_tag="BSU_24820" /old_locus_tag="BSU24820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390362.2" /db_xref="EnsemblGenomes-Gn:BSU24820" /db_xref="EnsemblGenomes-Tr:CAB14413" /db_xref="GOA:P54498" /db_xref="SubtiList:BG11688" /db_xref="UniProtKB/Swiss-Prot:P54498" /translation="MLMRSVCFILLAVLLFSLSACEPSHQQQKQASAAKDEKKDIIPL SAEKADGAEGWLNNSTILYTASNPTKTELFAYRIFTGKAKKLYQTDGQIVDVQINARE QMILLQITHSQKTAVVLLNAEGETLYEKDYETYELEAAWNQYDPYQMMVTEFNENWDF HTYQVNAKKDESFLSPVQVPFIHWTSKNTFDYVKEGRDDKTGPLYTFDTASKTEQKLE DNVLFFDSFHQMSFTVKSASGGKGTYQFKTPQSTSPVTAKWPLQAKYTSLAPMEYDYD EAGGLFYTFKQSGDAYKLAAINVASGETKDLVSLREMEPIQISPNGKYALYGFHFEQI ILLKSHETKQLIIDQKEME*" /label="yqgU CDS" gene complement(2165165..2166226) /gene="yqgU" /locus_tag="BSU_24820" /old_locus_tag="BSU24820" /label="yqgU gene" CDS complement(2166288..2167418) /gene="yqgT" /locus_tag="BSU_24830" /old_locus_tag="BSU24830" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12765833, 24163346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative d,l-endopeptidase" /protein_id="NP_390363.1" /db_xref="EnsemblGenomes-Gn:BSU24830" /db_xref="EnsemblGenomes-Tr:CAB14414" /db_xref="GOA:P54497" /db_xref="InterPro:IPR000834" /db_xref="InterPro:IPR034274" /db_xref="SubtiList:BG11687" /db_xref="UniProtKB/Swiss-Prot:P54497" /translation="MMAFITVKPEIKNNLANVAKELKIDEELLKSANRSAQKHQLYCP GYVIEEHSGKELQTIQDIKRFLQPRQLKLSDSWIEQEKIYDDSAVEKEIKKIIDVFPF VSCREIGRSVLGRPIWELKAGGEHAVKKVHMNASFHANEWITTSVLLKWFKEYCMSLC CNSPFFGFSPIKLFNSTSLSLVPLVNPDGVDLVLNGSEVMGARRDELERLNEHRPNFN EWKANINGVDLNKQFPSLWEIEKYRKPTAPSYRDFPGISPLTEPESIAMYRLITENPP DRLLALHTQGEEIYWGYKGLEPEESAAVIKEFEELSGNIYKGVRDIDSYAGFRDWFIH HYFKEGYTVELGKGQNPLPFQQFSHIYNATSGILWRALFFHE*" /label="yqgT CDS" gene complement(2166288..2167418) /gene="yqgT" /locus_tag="BSU_24830" /old_locus_tag="BSU24830" /label="yqgT gene" promotor_-10 complement(2167426..2167444) /Source="Nicolas_upshift_promotors" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2167458) /Source="Nicolas_upshifts" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2167460..2167465) /Source="Nicolas_upshift_promotors" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2167501..2169417) /gene="ltaSC" /locus_tag="BSU_24840" /old_locus_tag="BSU24840" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15187182, 21255105, 23103977, 25288647, 25666134" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 21255105, 23103977, 25288647, 25666134; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme responsible for polyglycerolphosphate LTAsynthesis" /protein_id="NP_390364.2" /db_xref="EnsemblGenomes-Gn:BSU24840" /db_xref="EnsemblGenomes-Tr:CAB14415" /db_xref="GOA:P54496" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG11686" /db_xref="UniProtKB/Swiss-Prot:P54496" /translation="MRKTFFSKISFMLIAILLMWLKTYAVYKTSFHIKIDNLTQEFIL FINPLSFLLLIFGLSLFLKGKNRNRYIIAMSCLVTFVLLANMVFYRFYNDFLTIPVLF QTSNMGDLGSSIGTLLEPTDLLLAVDIAVLIWLHIRQKAFQSDIPSTKNERAAYFLFV ASVYFFNLGLSEAERPQLLTRSFDREMLVKNISLFNFHIYDGVLQSKQSAQRALADSN SLTEIENYVTANAKDANKRLFGAAKGRNVILVSLESTQSFVINEKLNGEEITPFLNDF IKQSYNFNNVYHQTGQGKTSDSEFIVDNSLYPLGRGAVFFTNAGNQYMAAPEILKNSG YYSAVLHANNKSFWNRDLMYDSFGYDSFFDINSYDVTDENSVGWGLKDKEFFEQSSEL MKNLPQPFYSRLITLTNHFPFDLDEEDQLIDEYDSNSQTLNKYFPTVRYQDEALKRFI EKLKEDGLYDNSVIVLYGDHYGISENHNEAMGQFLGKEITPFEEVQLQKVPLVIHIPG ITDKKPQTIETVGGQIDIRPTLMNLLGIDTKDQIQFGNDLLSDEKLDFTVLRDGSFIT DQVVYTDGACYDKETGKPLEETKQCEAFADKAKQELSLSDEIIYGDLLRFYDQKRLDN SSKRKEKQMLDQAS*" /label="ltaSC CDS" gene complement(2167501..2169417) /gene="ltaSC" /locus_tag="BSU_24840" /old_locus_tag="BSU24840" /label="ltaSC gene" downshifts complement(2167528) /Source="Nicolas_upshifts" /id="D1290" /incds=0 /nref=5 /ntot=142 /MaxReadThrough="4.5611" /MaxDrop="3.8416" /score="15.4764643" /energy="-14.5" /TU="U1930,U1931" /idTUdmin="U1928" /TUdmin="-2667" /isTUend="FALSE" /label="downshifts" promotor_-35 2168533..2168539 /Source="Nicolas_upshift_promotors" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2168552..2169581 /Source="Nicolas_S_feature" /locus_tag="new_2569624_2570653" /HighExp="Etha, Gly, M9-stat, Salt, S8, LPhT, S7, Sw, HiTm, B60" /AntisenseName="yqgS" /AntisenseCor="-0.36996929809172002" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S931" upshifts 2168552 /Source="Nicolas_upshifts" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2168555..2168573 /Source="Nicolas_upshift_promotors" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="promotor_-10" S_feature complement(2169418..2169484) /Source="Nicolas_S_feature" /locus_tag="new_2570490_2570556_c" /HighExp="T-3.40H, BC, Sw, S5, Lbstat, T-5.40H, S4, ferm, C30, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S932" promotor_-10 complement(2169478..2169497) /Source="Nicolas_upshift_promotors" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2169484) /Source="Nicolas_upshifts" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2169512..2169519) /Source="Nicolas_upshift_promotors" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2169534..2170499) /gene="glcK" /locus_tag="BSU_24850" /old_locus_tag="BSU24850" /EC_number="2.7.1.59" /EC_number="2.7.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9620975, 10737197, 15018644, 15050034, 20495944, 21108133, 27324299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9620975, 10737197, 15018644, 15050034, 20495944, 21108133, 27324299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose kinase" /protein_id="NP_390365.2" /db_xref="EnsemblGenomes-Gn:BSU24850" /db_xref="EnsemblGenomes-Tr:CAB14416" /db_xref="GOA:P54495" /db_xref="InterPro:IPR000600" /db_xref="InterPro:IPR004654" /db_xref="SubtiList:BG11685" /db_xref="UniProtKB/Swiss-Prot:P54495" /translation="MDEIWFAGIDLGGTTIKLAFINQYGEIQHKWEVPTDKTGDTITV TIAKTIDSKLDELQKPKHIIKYIGMGAPGPVDMAAGVVYETVNLGWKNYALKNHLETE TGIPAVIENDANIAALGEMWKGAGDGAKDVILVTLGTGVGGGIIANGEIVHGINGAGG EIGHICSIPEGGAPCNCGKTGCIETIASATGIVRIAKEKIANAKKTTRLKATEQLSAR DVFEAAGENDEIALEVVDYVAKHLGLVLGNLASSLNPSKIVLGGGVSRAGELLRSKVE KTFRKCAFPRAAQAADISIAALGNDAGVIGGAWIAKNEWLKHQNC*" /label="glcK CDS" gene complement(2169534..2170499) /gene="glcK" /locus_tag="BSU_24850" /old_locus_tag="BSU24850" /label="glcK gene" CDS complement(2170510..2170725) /gene="yqgQ" /locus_tag="BSU_24860" /old_locus_tag="BSU24860" /function="9.3: Transcription factors" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15050034, 20057058; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative single strand nucleic acid binding transcription factor" /protein_id="NP_390366.1" /db_xref="EnsemblGenomes-Gn:BSU24860" /db_xref="EnsemblGenomes-Tr:CAB14417" /db_xref="InterPro:IPR009256" /db_xref="InterPro:IPR023164" /db_xref="PDB:2NN4" /db_xref="SubtiList:BG11684" /db_xref="UniProtKB/Swiss-Prot:P54494" /translation="MNTFYDVQQLLKTFGHIVYFGDRELEIEFMLDELKELYMNHMIE KEQWARAAAVLRKELEQTKNGRDFYKG*" /label="yqgQ CDS" gene complement(2170510..2170725) /gene="yqgQ" /locus_tag="BSU_24860" /old_locus_tag="BSU24860" /label="yqgQ gene" S_feature complement(2170726..2170834) /Source="Nicolas_S_feature" /locus_tag="new_2571798_2571906_c" /HighExp="M0t90, Lbstat, M40t90, M40t45, Lbtran, Mt0, dia5, Diami, M0t45, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S933" CDS complement(2170835..2172358) /gene="glpG" /locus_tag="BSU_24870" /old_locus_tag="BSU24870" /EC_number="3.4.21.105" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15050034, 16355228, 23518036, 26858402; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane endopeptidase" /protein_id="NP_390367.2" /db_xref="EnsemblGenomes-Gn:BSU24870" /db_xref="EnsemblGenomes-Tr:CAB14418" /db_xref="GOA:P54493" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="InterPro:IPR022764" /db_xref="InterPro:IPR035952" /db_xref="SubtiList:BG11683" /db_xref="UniProtKB/Swiss-Prot:P54493" /translation="MFLLEYTYWKIAAHLVNSGYGVIQAGESDEIWLEAPDKSSHDLV RLYKHDLDFRQEMVRDIEEQAERVERVRHQLGRRRMKLLNVFFSTEAPVDDWEEIAKK TFEKGTVSVEPAIVRGTMLRDDLQAVFPSFRTEDCSEEHASFENAQMARERFLSLVLK QEEQRKTEAAVFQNGKPTFTYLFIALQILMFFLLEINGGSTNTETLVAFGAKENSLIA QGEWWRLLTPIVLHIGIAHLAFNTLALWSVGTAVERMYGSGRFLLIYLAAGITGSIAS FVFSPYPSAGASGAIFGCLGALLYVALSNRKMFLRTIGTNIIVIIIINLGFGFAVSNI DNSGHIGGLIGGFFAAAALGLPKAGAFGKRLLSAVLLIALAVGFLYYGLHSPSHQESA LIQQASELYQEGKYEEVTELLNGEAAQKDASADLLKILAVSDIQIGEYDQAVSLLERA VKKEPKDHASYYNLALLYAEKNELAQAEKAIQTAVKLKPKEQRYKELQRQIENNKES* " /label="glpG CDS" gene complement(2170835..2172358) /gene="glpG" /locus_tag="BSU_24870" /old_locus_tag="BSU24870" /label="glpG gene" promotor_-10 complement(2172376..2172395) /Source="Nicolas_upshift_promotors" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2172389) /Source="Nicolas_upshifts" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2172410..2172417) /Source="Nicolas_upshift_promotors" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2172448..2172621) /gene="yqgO" /locus_tag="BSU_24880" /old_locus_tag="BSU24880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390368.1" /db_xref="EnsemblGenomes-Gn:BSU24880" /db_xref="EnsemblGenomes-Tr:CAB14419" /db_xref="SubtiList:BG11682" /db_xref="UniProtKB/Swiss-Prot:P54492" /translation="MKKLLIYAIFAVSAVMFYQNRYRLMNTVLSQPGIRRSFIHLFLR IPFIRNKFIQQAF*" /label="yqgO CDS" gene complement(2172448..2172621) /gene="yqgO" /locus_tag="BSU_24880" /old_locus_tag="BSU24880" /label="yqgO gene" downshifts complement(2172475) /Source="Nicolas_upshifts" /id="D1291" /incds=0 /nref=121 /ntot=211 /MaxReadThrough="2.93694" /MaxDrop="5.6047" /score="19.2452946" /energy="-8.9" /TU="NA" /idTUdmin="U1932" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2172637..2172648) /Source="Nicolas_upshift_promotors" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2172649) /Source="Nicolas_upshifts" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2172662..2172668) /Source="Nicolas_upshift_promotors" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2172688..2173251) /gene="folN" /locus_tag="BSU_24890" /old_locus_tag="BSU24890" /EC_number="6.3.3.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17329806, 20952389, 22773193; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-formyltetrahydrofolate cyclo-ligase" /protein_id="NP_390369.1" /db_xref="EnsemblGenomes-Gn:BSU24890" /db_xref="EnsemblGenomes-Tr:CAB14420" /db_xref="GOA:P54491" /db_xref="InterPro:IPR002698" /db_xref="PDB:1YDM" /db_xref="SubtiList:BG11681" /db_xref="UniProtKB/Swiss-Prot:P54491" /translation="MKSQLRKKTLEALSALSNEDILQKTERMYKYLFSLPEWQNAGTI AVTISRGLEIPTRPVIEQAWEEGKQVCIPKCHPDTKKMQFRTYQTDDQLETVYAGLLE PVIEKTKEVNPSQIDLMIVPGVCFDVNGFRVGFGGGYYDRYLSEYEGKTVSLLLECQL FAHVPRLPHDIPVHKLITEDRIISCFS*" /label="folN CDS" gene complement(2172688..2173251) /gene="folN" /locus_tag="BSU_24890" /old_locus_tag="BSU24890" /label="folN gene" S_feature complement(2173252..2173335) /Source="Nicolas_S_feature" /locus_tag="new_2574324_2574407_c" /HighExp="Cold, G180, LBGexp, LBGtran, G135, HPh, LPh, dia0, Oxctl, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S934" CDS complement(2173336..2173485) /gene="rpmGA" /locus_tag="BSU_24900" /old_locus_tag="BSU24900" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12904577, 19648245, 22720735, 23002217, 27561249; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L33" /protein_id="NP_570908.2" /db_xref="EnsemblGenomes-Gn:BSU24900" /db_xref="EnsemblGenomes-Tr:CAE01461" /db_xref="GOA:P56849" /db_xref="InterPro:IPR001705" /db_xref="InterPro:IPR011332" /db_xref="InterPro:IPR018264" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG14180" /db_xref="UniProtKB/Swiss-Prot:P56849" /translation="MRVNITLACTECGERNYISKKNKRNNPDRVEFKKYCPRDKKSTL HRETK*" /label="rpmGA CDS" gene complement(2173336..2173485) /gene="rpmGA" /locus_tag="BSU_24900" /old_locus_tag="BSU24900" /label="rpmGA gene" downshifts complement(2173382) /Source="Nicolas_upshifts" /id="D1292" /incds=0 /nref=154 /ntot=253 /MaxReadThrough="5.3064" /MaxDrop="4.5881" /score="34.7393253" /energy="-15.3" /TU="U1933" /idTUdmin="U1932" /TUdmin="-907" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2173522..2173541) /Source="Nicolas_upshift_promotors" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2173532) /Source="Nicolas_upshifts" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2173557..2173560) /Source="Nicolas_upshift_promotors" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2173569..2174648) /gene="yqgM" /locus_tag="BSU_24910" /old_locus_tag="BSU24910" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_390370.2" /db_xref="EnsemblGenomes-Gn:BSU24910" /db_xref="EnsemblGenomes-Tr:CAB14421" /db_xref="GOA:P54490" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11680" /db_xref="UniProtKB/Swiss-Prot:P54490" /translation="MNILMLSPEHPDEPKSGLGVHLNRLISYLNPHINITVFTPSGQL FSYAKFEDYIADANFTMVRHVLSHNKRFDLIHAHDDTTAPAAQYLKQRLGLPLAATIH GLESERKKVCREAPHPYRLMTERLLIESADALIVLSTFMKRSLDKAAHKKITVIPSPA SMEEEKGKIPRSMNRRFLFSYGRFVPEKGLSQLLKVFAILKQRQPDLYLVLAGEGPSL SCYEKLAAAYNLKDRVMFLPFLNRKDIRTLLSHCEMAVFPSSYEPFGLAAQESMEQGV LTVVSQSGGFCDYAVHDKTAIIADFTLVQEAADLLDSFLKDREKARRIKEAGRQQVFK LHHPRLIMSSYLQLYERIFNNSAIH*" /label="yqgM CDS" gene complement(2173569..2174648) /gene="yqgM" /locus_tag="BSU_24910" /old_locus_tag="BSU24910" /label="yqgM gene" CDS complement(2174645..2175115) /gene="yqgL" /locus_tag="BSU_24920" /old_locus_tag="BSU24920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390371.1" /db_xref="EnsemblGenomes-Gn:BSU24920" /db_xref="EnsemblGenomes-Tr:CAB14422" /db_xref="SubtiList:BG11679" /db_xref="UniProtKB/Swiss-Prot:P54489" /translation="MDKHPFPYNIRHKLSFFRDTFDIIIQNAHTLTVSWEISEETMRL AEAVLFEKTQDMIKELRIVIKRKDIEAVRTKRTTYDKGEWTIRQAAGDAVYRAEYRIV NSMNVSLKLAGTDDIYLDENGIRHINSFQIEEAHTRWEAQFSAYTCYGRGEKER*" /label="yqgL CDS" gene complement(2174645..2175115) /gene="yqgL" /locus_tag="BSU_24920" /old_locus_tag="BSU24920" /label="yqgL gene" promotor_-35 2175060..2175068 /Source="Nicolas_upshift_promotors" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2175082..2175090 /Source="Nicolas_upshift_promotors" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2175083..2175256 /Source="Nicolas_S_feature" /locus_tag="new_2576155_2576328" /HighExp="M9-stat, T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, Lbstat, T3.30H, B60" /AntisenseName="yqgL" /AntisenseCor="0.210779859401483" /AntisenseRegPval="-3.3" /CDS_PredictionProba="NA" /TUshortSig="SigI" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S935" upshifts 2175084 /Source="Nicolas_upshifts" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2175151..2175170) /Source="Nicolas_upshift_promotors" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2175163) /Source="Nicolas_upshifts" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2175182..2175189) /Source="Nicolas_upshift_promotors" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2175228..2175232 /Source="Nicolas_upshift_promotors" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2175248..2175267 /Source="Nicolas_upshift_promotors" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2175258 /Source="Nicolas_upshifts" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="upshifts" CDS 2175295..2175648 /gene="yqzD" /locus_tag="BSU_24930" /old_locus_tag="BSU24930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390372.1" /db_xref="EnsemblGenomes-Gn:BSU24930" /db_xref="EnsemblGenomes-Tr:CAB14423" /db_xref="GOA:O32022" /db_xref="SubtiList:BG13770" /db_xref="UniProtKB/Swiss-Prot:O32022" /translation="MEIAIIALFIVSIALIAFSYSQRDPMKDVEQELETLQLSAMQEI YKLKKKMTVLEEELLETNLVIRKSKQNDINQKIAKQILSKYNNGMSAEAIAKAEHVSV EDVNTIIKDNEKVLV*" /label="yqzD CDS" gene 2175295..2175648 /gene="yqzD" /locus_tag="BSU_24930" /old_locus_tag="BSU24930" /label="yqzD gene" CDS 2175645..2176109 /gene="yqzC" /locus_tag="BSU_24940" /old_locus_tag="BSU24940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390373.2" /db_xref="EnsemblGenomes-Gn:BSU24940" /db_xref="EnsemblGenomes-Tr:CAB14424" /db_xref="InterPro:IPR003770" /db_xref="SubtiList:BG13769" /db_xref="UniProtKB/Swiss-Prot:O32023" /translation="MTKRGIQAFAGGIILATAVLAAVFYLTDEDQAAAVKDNKTVTEQ DVNNYLDSKKLVSVNRDEYQKLLDSKEKSLNNDSGSDTKSDKVKTYKLTIKDGMSTAD VSAILEKEGIISSAQDFNDYVIDAGYHKEIRAGEFKVKSDMSFKKIVKTLTR*" /label="yqzC CDS" gene 2175645..2176109 /gene="yqzC" /locus_tag="BSU_24940" /old_locus_tag="BSU24940" /label="yqzC gene" downshifts 2176095 /Source="Nicolas_upshifts" /id="D1293" /incds=0 /nref=216 /ntot=264 /MaxReadThrough="0.9847" /MaxDrop="6.07831" /score="21.2108939" /energy="-8.8" /TU="NA" /idTUdmin="U1934" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2176138..2176920) /gene="pstBB" /locus_tag="BSU_24950" /old_locus_tag="BSU24950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8760913, 9098050, 12897025, 15289558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8760913, 9098050, 12897025, 15289558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (ATP-binding protein)" /protein_id="NP_390374.1" /db_xref="EnsemblGenomes-Gn:BSU24950" /db_xref="EnsemblGenomes-Tr:CAB14425" /db_xref="GOA:P46342" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR015850" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11379" /db_xref="UniProtKB/Swiss-Prot:P46342" /translation="MSIATEAVMKQEVYQVNGMNLWYGQHHALKNINLSIYENEVTAI IGPSGCGKSTFIKTLNLMIQMTPNVKLAGELNYNGSNILKDKVDIVDLRKNIGMVFQK GNPFPQSIFDNVAYGPRVHGTKNKKKLQEIVEKSLKDVALWDEVKDRLHTSALSLSGG QQQRLCIARALATNPDILLMDEPTSALDPISTRKIEELILELKDKYTIVIVTHNMQQA ARVSDQTAFFYMGELVECDNTNKMFSNPKDQRTLDYISGKFG*" /label="pstBB CDS" gene complement(2176138..2176920) /gene="pstBB" /locus_tag="BSU_24950" /old_locus_tag="BSU24950" /label="pstBB gene" downshifts complement(2176149) /Source="Nicolas_upshifts" /id="D1294" /incds=0 /nref=20 /ntot=46 /MaxReadThrough="2.29658" /MaxDrop="6.53816" /score="26.1659198" /energy="-8.8" /TU="NA" /idTUdmin="U1937" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2176931..2177740) /gene="pstBA" /locus_tag="BSU_24960" /old_locus_tag="BSU24960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8760913, 9098050, 12897025, 15289558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8760913, 9098050, 12897025, 15289558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (ATP-binding protein)" /protein_id="NP_390375.1" /db_xref="EnsemblGenomes-Gn:BSU24960" /db_xref="EnsemblGenomes-Tr:CAB14426" /db_xref="GOA:P46341" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR015850" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11378" /db_xref="UniProtKB/Swiss-Prot:P46341" /translation="MSEQMVKEKPERAVIVPKQNHVLEVKDLSIYYGNKQAVHHVNMD IEKNAVTALIGPSGCGKSTFLRNINRMNDLIPSARAEGEILYEGLNILGGNINVVSLR REIGMVFQKPNPFPKSIYANITHALKYAGERNKAVLDEIVEESLTKAALWDEVKDRLH SSALSLSGGQQQRLCIARTLAMKPAVLLLDEPASALDPISNAKIEELITGLKREYSII IVTHNMQQALRVSDRTAFFLNGELVEYGQTEQIFTSPKKQKTEDYINGKFG*" /label="pstBA CDS" gene complement(2176931..2177740) /gene="pstBA" /locus_tag="BSU_24960" /old_locus_tag="BSU24960" /label="pstBA gene" CDS complement(2177761..2178645) /gene="pstA" /locus_tag="BSU_24970" /old_locus_tag="BSU24970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 12897025, 15289558, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 12897025, 15289558, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (permease)" /protein_id="NP_390376.2" /db_xref="EnsemblGenomes-Gn:BSU24970" /db_xref="EnsemblGenomes-Tr:CAB14427" /db_xref="GOA:P46340" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR005672" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11377" /db_xref="UniProtKB/Swiss-Prot:P46340" /translation="MNRKITDKLATGMFGLCAAIIAAILVGLFSYIIINGVSQLSFQF ITTKSSAIAAGGGIRDQLFNSFYILFITMLITIPLGVGGGVFMAEYAPNNKVTDFIRT CIEVLSSLPSIVIGMFGLLMFVNLTGWGYTIIGGALALTVFNLPVMVRVTEDAIRSVP KDLKEASLALGVSRWHTVKTVLIPSAIPSIITGAILASGRVFGEAAALLFTAGLTTPR LNFTEWNPFSETSPLNIFRPAETLAVHIWNVNTQGMIPDAEAIANGGSAVLVISVLVF NLAARWLGTMIYKKLTAN*" /label="pstA CDS" gene complement(2177761..2178645) /gene="pstA" /locus_tag="BSU_24970" /old_locus_tag="BSU24970" /label="pstA gene" CDS complement(2178645..2179574) /gene="pstC" /locus_tag="BSU_24980" /old_locus_tag="BSU24980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 12897025, 15289558, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 12897025, 15289558, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (permease)" /protein_id="NP_390377.2" /db_xref="EnsemblGenomes-Gn:BSU24980" /db_xref="EnsemblGenomes-Tr:CAB14428" /db_xref="GOA:P46339" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR011864" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11376" /db_xref="UniProtKB/Swiss-Prot:P46339" /translation="MINNRENMSVSERLISSRQNRQLDEVRGRMIVTACALIMIAASV AITIFLGVKGLQSFLVNGVSPIEFLTSLNWNPTDSDPKYGVLPFIFGSFAVTILSALI AAPLGIAGAIFMTEIAPNWGKKVLQPVIELLVGIPSVVYGFIGLTVLVPFIAQFKSSG TGHSLLAGTIVLSVMILPTITSISADAMASLPKSLREGSYALGATRWQTIRKVLVPAA FPTLMTAVVLGMARAFGEALAVQMVIGNTRVLPESPFDTAGTLTTIITLNMGHTTYGS VENNTLWSMGLVLLVMSFLFILLIRYLSSRRKV*" /label="pstC CDS" gene complement(2178645..2179574) /gene="pstC" /locus_tag="BSU_24980" /old_locus_tag="BSU24980" /label="pstC gene" CDS complement(2179643..2180545) /gene="pstS" /locus_tag="BSU_24990" /old_locus_tag="BSU24990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 9593301, 10913081, 15289558, 21461370, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 9593301, 10913081, 15289558, 21461370, 25355936; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (phosphate binding lipoprotein)" /protein_id="NP_390378.1" /db_xref="EnsemblGenomes-Gn:BSU24990" /db_xref="EnsemblGenomes-Tr:CAB14429" /db_xref="GOA:P46338" /db_xref="InterPro:IPR011862" /db_xref="InterPro:IPR024370" /db_xref="SubtiList:BG11375" /db_xref="UniProtKB/Swiss-Prot:P46338" /translation="MKKNKLVLMLLMAAFMMIAAACGNAGESKKSNSDSAKGEEKASG SLTISGSSAMQPLVLAAAEKFMEENPDADIQVQAGGSGTGLSQVSEGAVQIGNSDVFA EEKEGIDAKALVDHQVAVVGMAAAVNPDAGVKDISKDELKKIFTGKIKNWKELGGKDQ KITLVNRPDSSGTRATFVKYALDGAEPAEGITEDSSNTVKKIIADTPGAIGYLAFSYL TDDKVTALSIDGVKPEAKNVATGEYPIWAYQHSYTKGEATGLAKEFLDYLKSEDIQKS IVTDQGYIPVTDMKVTRDANGKQS*" /label="pstS CDS" gene complement(2179643..2180545) /gene="pstS" /locus_tag="BSU_24990" /old_locus_tag="BSU24990" /label="pstS gene" upshifts complement(2180600) /Source="Nicolas_upshifts" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2180608..2180624) /Source="Nicolas_upshift_promotors" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2180635..2180637) /Source="Nicolas_upshift_promotors" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="promotor_-35" Polymorphism join(2180654,2180656) /Source="geneious" /ID="SNP_BsDelta6_2581727_2581726" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(T)6 -> (T)7" /Codon_Change /Coverage=117 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=114 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" CDS complement(2180700..2182850) /gene="pbpA" /locus_tag="BSU_25000" /old_locus_tag="BSU25000" /EC_number="3.4.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9139922, 9851991, 12896990, 17307860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9139922, 9851991, 12896990, 17307860; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transpeptidase (penicillin-binding protein 2A)" /protein_id="NP_390379.1" /db_xref="EnsemblGenomes-Gn:BSU25000" /db_xref="EnsemblGenomes-Tr:CAB14430" /db_xref="GOA:P54488" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG11678" /db_xref="UniProtKB/Swiss-Prot:P54488" /translation="MRRNKPKKQNHKEKKKSLPIRLNILFLAAFVIFTWIIVELGIKQ IVQGDDYKNQANKQEQSEVSSAVPRGKIYDRNFNAIVTNKALNAITYTRSKSTTQEQR LKIAKKLSDMIKVDTKKVTERDKKDYWILTRPKEAKKLISSKERQQVEDKKISDDDLY QLQLKRITDKQLNELTDKDMQILAIKRQMDSGYALTPQYIKNEDVSAKEMAVVSEHLD ELPGVDVTSDWEREYPYKNLLRSVLGSVSSSNEGLPSNLLDHYLSLGYSRNDRVGKSY LEYQYESLLQGQKAKVENITDSKGNVTGTKTVSEGKAGKDLVLTIDIDLQKSVEKIIE KKLKAAKARPSTELLDRAFVVMMDPRNGEVLTMAGKQIKRENGAYKFDDYALGAMTSS YAMGSAVKGATVLTGLQTGAINLNTVFKDEPLYIGQDKRGKKSWQNLGPVGIQTALEK SSNVFMFKTAIAVGKGEYKPHQALPLDTSAFDTFRNYFSQFGLGVKTGIDLPNEMTGY KGTSRLSGFLLDFAIGQYDTYTPLELAQYVSTIANGGYRMKPQLVKEVRDSNAKKGIG AVVDSVQPEVLNKVDMKSSYIEEVQAGFRRVATKGTAAGQLASASYKPAAKTGTAQSF YDGPDKSKTGTDTYNTTLVAYAPADNPEIAISVVVPWTYIDYNQRYSITNEIGREVMD KYFELKSKQDKEGTQQKNKDKIEENAENTTSSDN*" /label="pbpA CDS" gene complement(2180700..2182850) /gene="pbpA" /locus_tag="BSU_25000" /old_locus_tag="BSU25000" /label="pbpA gene" downshifts complement(2180710) /Source="Nicolas_upshifts" /id="D1295" /incds=0 /nref=255 /ntot=278 /MaxReadThrough="1.22121" /MaxDrop="8.82988" /score="31.2726004" /energy="-10" /TU="U1940" /idTUdmin="U1938" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2181444..2181462) /Source="Nicolas_upshift_promotors" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2181452) /Source="Nicolas_upshifts" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2181478..2181484) /Source="Nicolas_upshift_promotors" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2182139..2182158) /Source="Nicolas_upshift_promotors" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2182156) /Source="Nicolas_upshifts" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2182172..2182181) /Source="Nicolas_upshift_promotors" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2182900..2182919) /Source="Nicolas_upshift_promotors" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2182905) /Source="Nicolas_upshifts" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2182935..2182939) /Source="Nicolas_upshift_promotors" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2182964..2184256) /gene="yqgE" /locus_tag="BSU_25010" /old_locus_tag="BSU25010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390380.2" /db_xref="EnsemblGenomes-Gn:BSU25010" /db_xref="EnsemblGenomes-Tr:CAB14431" /db_xref="GOA:P54487" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11677" /db_xref="UniProtKB/Swiss-Prot:P54487" /translation="MSKLKKVIGDVDVNKGLLFLLTIGGLYSLGIALSNTFVNVYLWK QSGKFIDLAIYNLSIVTMQPITFYLAGRLAKKIDRVFILRFGVIFLAAFYLSVLLAGE TAASRLVLIGAVLGVGYGFYWLAFNVLTFEITEPDTRDFFNGFMGILSSSAGMIGPIV AGFVISRLENNTGYTVIFSLSLSLFALAVVMSFFLKRRESKGRFMLSKVFGERHSNMN WRRITNAHFFQGLREGIFVFLISVFVFIETNSELALGTFGLVNSAVSFFAYYFASRLI KKKARKKSILLGGLILYGALFLILFHMSFSTLLTYGVFIAIGYPLLLVPYVSLTYDVI GRARHARKARIEYIVLREMFLNAGRIVSILCFLLIVALLKEDVGIPLSLAILGIGHPL IYYFVKDIRFKEKEGENETMEEDGQKRVTEPTLLKGER*" /label="yqgE CDS" gene complement(2182964..2184256) /gene="yqgE" /locus_tag="BSU_25010" /old_locus_tag="BSU25010" /label="yqgE gene" promotor_-10 complement(2184279..2184290) /Source="Nicolas_upshift_promotors" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2184290) /Source="Nicolas_upshifts" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2184304..2184310) /Source="Nicolas_upshift_promotors" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2184363..2184971) /gene="sodA" /locus_tag="BSU_25020" /old_locus_tag="BSU25020" /EC_number="1.15.1.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9393707, 9573176, 9658017, 10074093, 15897454, 18084079, 25445927" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9393707, 9573176, 9658017, 10074093, 15897454, 18084079, 25445927; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="superoxide dismutase (Mn[2+]-dependent)" /protein_id="NP_390381.3" /db_xref="EnsemblGenomes-Gn:BSU25020" /db_xref="EnsemblGenomes-Tr:CAB14432" /db_xref="GOA:P54375" /db_xref="InterPro:IPR001189" /db_xref="InterPro:IPR019831" /db_xref="InterPro:IPR019832" /db_xref="InterPro:IPR019833" /db_xref="InterPro:IPR036314" /db_xref="InterPro:IPR036324" /db_xref="PDB:2RCV" /db_xref="SubtiList:BG11676" /db_xref="UniProtKB/Swiss-Prot:P54375" /translation="MAYELPELPYAYDALEPHIDKETMTIHHTKHHNTYVTNLNKAVE GNTALANKSVEELVADLDSVPENIRTAVRNNGGGHANHKLFWTLLSPNGGGEPTGALA EEINSVFGSFDKFKEQFAAAAAGRFGSGWAWLVVNNGKLEITSTPNQDSPLSEGKTPI LGLDVWEHAYYLNYQNRRPDYISAFWNVVNWDEVARLYSEAK*" /label="sodA CDS" gene complement(2184363..2184971) /gene="sodA" /locus_tag="BSU_25020" /old_locus_tag="BSU25020" /label="sodA gene" downshifts complement(2184378) /Source="Nicolas_upshifts" /id="D1296" /incds=0 /nref=265 /ntot=268 /MaxReadThrough="4.329" /MaxDrop="9.16338" /score="3.26408916" /energy="-8.1" /TU="U1943" /idTUdmin="U1942" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2185023..2185042) /Source="Nicolas_upshift_promotors" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2185034) /Source="Nicolas_upshifts" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2185036..2185104) /Source="Nicolas_S_feature" /locus_tag="new_2586107_2586175_c" /HighExp="Etha, Salt, Heat, LPhT, Gly, Sw, S4, LoTm, M9-stat, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigB" /TUlongPSig="0.999" /label="S936" promotor_-35 complement(2185057..2185064) /Source="Nicolas_upshift_promotors" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2185095..2185113) /Source="Nicolas_upshift_promotors" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2185104) /Source="Nicolas_upshifts" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2185128..2185134) /Source="Nicolas_upshift_promotors" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2185150..2185632) /gene="yqgC" /locus_tag="BSU_25030" /old_locus_tag="BSU25030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral inner membrane protein of unknown function" /protein_id="NP_390382.1" /db_xref="EnsemblGenomes-Gn:BSU25030" /db_xref="EnsemblGenomes-Tr:CAB14433" /db_xref="GOA:P54486" /db_xref="InterPro:IPR007403" /db_xref="SubtiList:BG11675" /db_xref="UniProtKB/Swiss-Prot:P54486" /translation="MDMLYWLLIAAVFIIAFIGLVYPVIPSVVFIVAGFVLYGFLFSF SPYSYMFWLVEAVFAAVLFAADYVSNLLGVKRFGGSKAAIWGSTIGLLIGPFVIPVAG IILGPFIGAVCAELIVHQKDLKSAFKIGLGSLIGFLTGVIAKGIIQLLMIGYFLWTVL *" /label="yqgC CDS" gene complement(2185150..2185632) /gene="yqgC" /locus_tag="BSU_25030" /old_locus_tag="BSU25030" /label="yqgC gene" S_feature complement(2185633..2185925) /Source="Nicolas_S_feature" /locus_tag="new_2586704_2586996_c" /HighExp="Etha, Gly, Salt, aero, S0, LoTm, HiTm, LPh, nit, ferm" /AntisenseName="yqgB" /AntisenseCor="9.8584854910492598E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S937" promotor_-35 2185675..2185681 /Source="Nicolas_upshift_promotors" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2185696..2185715 /Source="Nicolas_upshift_promotors" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2185709 /Source="Nicolas_upshifts" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="upshifts" CDS 2185742..2186509 /gene="yqgB" /locus_tag="BSU_25040" /old_locus_tag="BSU25040" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15294815; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="factor involved in motility" /protein_id="NP_390383.2" /db_xref="EnsemblGenomes-Gn:BSU25040" /db_xref="EnsemblGenomes-Tr:CAB14434" /db_xref="GOA:P54485" /db_xref="InterPro:IPR009574" /db_xref="SubtiList:BG11674" /db_xref="UniProtKB/Swiss-Prot:P54485" /translation="MNVFQLFIKSTYSPRDIAKTRFQGIGKAILYVFLLSVLFAIPTA YYVSTGTVKSMNGFKTVLNKDFPDFTISNGKLQTDEKKATESQANGFVIVFDPTDSYG TEQIEAKQNAIGILQNKFVLAIDGQAQEMSYSMMPSELQKKDVIAGLNQNKAMIVTVL SALIFLVTAAGKFIEVSFLALIGLIIKNSQKKHLSYHQLWKLSAYSITLSTVFFTIMR ALEATVPSEFLLNWFVNFVILFLVLKEIPSKKVINKS*" /label="yqgB CDS" gene 2185742..2186509 /gene="yqgB" /locus_tag="BSU_25040" /old_locus_tag="BSU25040" /label="yqgB gene" promotor_-10 complement(2185923..2185941) /Source="Nicolas_upshift_promotors" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="promotor_-10" upshifts complement(2185925) /Source="Nicolas_upshifts" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="upshifts" S_feature complement(2185927..2186863) /Source="Nicolas_S_feature" /locus_tag="new_2586998_2587934_c" /HighExp="S0, S1, aero, M0t45, HPh, Lbtran, LPh, GM 120, nit, M/G" /AntisenseName="yqgB" /AntisenseCor="0.31978785018705103" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S938" promotor_-35 complement(2185955..2185961) /Source="Nicolas_upshift_promotors" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="promotor_-35" S_feature 2186510..2186940 /Source="Nicolas_S_feature" /locus_tag="new_2587581_2588011" /HighExp="C30, HiOs, UNK1, Gly, Fru, S8, Salt, MG 5, S7, MG 25" /AntisenseName="yqgA" /AntisenseCor="0.170248276038857" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.731" /TUlongSig="NA" /TUlongPSig="NA" /label="S939" downshifts 2186897 /Source="Nicolas_upshifts" /id="D1297" /incds=0 /nref=5 /ntot=131 /MaxReadThrough="3.89102" /MaxDrop="3.29021" /score="30.8580926" /energy="-13.8" /TU="U1944" /idTUdmin="U1944" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts complement(2186908) /Source="Nicolas_upshifts" /id="D1298" /incds=0 /nref=15 /ntot=207 /MaxReadThrough="6.7306" /MaxDrop="3.9194" /score="7.48192829" /energy="-14.3" /TU="U1947" /idTUdmin="U1945" /TUdmin="-1848" /isTUend="FALSE" /label="downshifts" CDS complement(2186925..2187353) /gene="yqgA" /locus_tag="BSU_25050" /old_locus_tag="BSU25050" /experiment="publication(s) with functional evidences, PMID:25130749, 27797724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25130749, 27797724; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="cell wall protein" /protein_id="NP_390384.2" /db_xref="EnsemblGenomes-Gn:BSU25050" /db_xref="EnsemblGenomes-Tr:CAB14435" /db_xref="GOA:P54484" /db_xref="SubtiList:BG11673" /db_xref="UniProtKB/Swiss-Prot:P54484" /translation="MKQGKFSVFLILLLMLTLVVAPKEKAEAASSGWQPVSGISGCKI RVITDAYTYTKSATSIDAYAETNGKCGKLNYKSFGVSIVEGGDIGPQYSGYFSSRTPT KKFYFSKLPKPTGTPWAVGLSVYKGKAKGAAFVYINPQKR*" /label="yqgA CDS" gene complement(2186925..2187353) /gene="yqgA" /locus_tag="BSU_25050" /old_locus_tag="BSU25050" /label="yqgA gene" promotor_-35 2187349..2187353 /Source="Nicolas_upshift_promotors" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="promotor_-35" promotor_-10 2187363..2187377 /Source="Nicolas_upshift_promotors" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="promotor_-10" upshifts 2187372 /Source="Nicolas_upshifts" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="upshifts" promotor_-10 complement(2187376..2187395) /Source="Nicolas_upshift_promotors" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="promotor_-10" upshifts complement(2187399) /Source="Nicolas_upshifts" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="upshifts" promotor_-35 complement(2187410..2187417) /Source="Nicolas_upshift_promotors" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="promotor_-35" promotor_-35 2187568..2187573 /Source="Nicolas_upshift_promotors" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2187589..2187607 /Source="Nicolas_upshift_promotors" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2187601 /Source="Nicolas_upshifts" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="upshifts" CDS 2187630..2187929 /gene="yqfZ" /locus_tag="BSU_25060" /old_locus_tag="BSU25060" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15294815; Product type ph : phenotype" /codon_start=1 /transl_table=11 /product="factor involved in motility" /protein_id="NP_390385.1" /db_xref="EnsemblGenomes-Gn:BSU25060" /db_xref="EnsemblGenomes-Tr:CAB14436" /db_xref="GOA:P54483" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR020506" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11672" /db_xref="UniProtKB/Swiss-Prot:P54483" /translation="MKRLTLVCSIVFILFILFYDLKIGTIPIQDLPVYEASAKTAVQE PAYKTVKVKPGDTVMSIVGSAGSPDDIVKDFEALNPNVKANAIQAGTAYKFPVYP*" /label="yqfZ CDS" gene 2187630..2187929 /gene="yqfZ" /locus_tag="BSU_25060" /old_locus_tag="BSU25060" /label="yqfZ gene" promotor_-35 2187942..2187949 /Source="Nicolas_upshift_promotors" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2187964..2187983 /Source="Nicolas_upshift_promotors" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2187975..2188051 /Source="Nicolas_S_feature" /locus_tag="new_2589046_2589122" /HighExp="Diami, dia5, dia15, H2O2, Etha, Salt, LBGexp, Oxctl, Paraq, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.999, 1" /TUlongSig="Sig-" /TUlongPSig=0 /label="S940" upshifts 2187975 /Source="Nicolas_upshifts" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="upshifts" CDS 2188052..2189185 /gene="ispG" /locus_tag="BSU_25070" /old_locus_tag="BSU25070" /EC_number="1.17.7.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12571359, 16268586, 25212876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase)" /protein_id="NP_390386.1" /db_xref="EnsemblGenomes-Gn:BSU25070" /db_xref="EnsemblGenomes-Tr:CAB14437" /db_xref="GOA:P54482" /db_xref="InterPro:IPR004588" /db_xref="InterPro:IPR011005" /db_xref="InterPro:IPR016425" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG11671" /db_xref="UniProtKB/Swiss-Prot:P54482" /translation="MQVSEITHRTKTRPVKVGPLTIGGNNEVVIQSMTTTKTHDVEAT VAEINRLAEAGCQIVRVACPDERAANAIADIKKRISIPLVVDIHFDYKLALKAIEGGA DKIRINPGNIGRREKVEAVVKAAKDKGIPIRIGVNAGSLEKRILEKYGYPTADGMVES ALHHIKILEDLDFHDIIVSMKASDVNLAIEAYEKAAKAFDYPLHLGITESGTLFAGTV KSAAGLGAILSKGIGNTMRISLSADPVEEVKVARELLKSFGLASNAATLISCPTCGRI EIDLISIANEVEEYISKIKAPIKVAVLGCAVNGPGEAREADIGIAGARGEGLLFRKGK IVRKVPEETMVEELKKEIDILAEEHYAKLEAEKAKLKEETQKA*" /label="ispG CDS" gene 2188052..2189185 /gene="ispG" /locus_tag="BSU_25070" /old_locus_tag="BSU25070" /label="ispG gene" downshifts 2189166 /Source="Nicolas_upshifts" /id="D1299" /incds=0 /nref=230 /ntot=267 /MaxReadThrough="2.62035" /MaxDrop="8.92434" /score="30.8580926" /energy="-13.8" /TU="NA" /idTUdmin="U1948" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(2189211..2189600) /gene="yqfX" /locus_tag="BSU_25080" /old_locus_tag="BSU25080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312, 22882546" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function expressed in germinating spores" /protein_id="NP_390387.1" /db_xref="EnsemblGenomes-Gn:BSU25080" /db_xref="EnsemblGenomes-Tr:CAB14438" /db_xref="GOA:P54481" /db_xref="SubtiList:BG11670" /db_xref="UniProtKB/Swiss-Prot:P54481" /translation="MKVANDYEKRDNNSYYVDHGSEGTNITRDNDGFFEETAAEIAEP YRAADRSNDQDNDRSGGNVNEGRGIGYIALALSIISLFVLPVLLGAAGIIVGYIARRR GAQGLGAWAMGIGVVSLVLGIFIIPFF*" /label="yqfX CDS" gene complement(2189211..2189600) /gene="yqfX" /locus_tag="BSU_25080" /old_locus_tag="BSU25080" /label="yqfX gene" downshifts complement(2189237) /Source="Nicolas_upshifts" /id="D1300" /incds=0 /nref=10 /ntot=62 /MaxReadThrough="1.85077" /MaxDrop="8.74353" /score="28.1764525" /energy="-13.8" /TU="NA" /idTUdmin="U1950" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2189631..2189642) /Source="Nicolas_upshift_promotors" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2189635) /Source="Nicolas_upshifts" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2189656..2189662) /Source="Nicolas_upshift_promotors" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2189675..2189682 /Source="Nicolas_upshift_promotors" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2189693..2189712 /Source="Nicolas_upshift_promotors" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2189694 /Source="Nicolas_upshifts" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="upshifts" CDS 2189733..2190314 /gene="yqfW" /locus_tag="BSU_25090" /old_locus_tag="BSU25090" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleotidase" /protein_id="NP_390388.1" /db_xref="EnsemblGenomes-Gn:BSU25090" /db_xref="EnsemblGenomes-Tr:CAB14439" /db_xref="GOA:P54480" /db_xref="InterPro:IPR009206" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11669" /db_xref="UniProtKB/Swiss-Prot:P54480" /translation="MLRLGIDIDGTITAQDTFVPYLNRSFNLSISLNDMTDYDLTKLL NITQEEFWDWMNQNEAIIYKEALLAQHAKQSLDLLKEEHKLIYITARRTHLTDITYEW FDRQNIHYDHIELVGGHHKVEAVKNHNIDLFFEDHHGNAMMIAKEAGIPVILFNSPYN QLPIDSNIIRVNNWLEAVQWMNNNKHHLIRVNN*" /label="yqfW CDS" gene 2189733..2190314 /gene="yqfW" /locus_tag="BSU_25090" /old_locus_tag="BSU25090" /label="yqfW gene" downshifts 2190312 /Source="Nicolas_upshifts" /id="D1301" /incds=0 /nref=34 /ntot=240 /MaxReadThrough="4.07255" /MaxDrop="4.44714" /score="-2.90660182" /energy="-8" /TU="U1951" /idTUdmin="U1951" /TUdmin="-611" /isTUend="FALSE" /label="downshifts" S_feature 2190357..2190965 /Source="Nicolas_S_feature" /locus_tag="new_2591428_2592036" /HighExp="LoTm, S8, Cold, S7, S5, Sw, BC, S6, HiOs, B60" /AntisenseName="zur" /AntisenseCor="-0.265512398914523" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S941" CDS complement(2190357..2190794) /gene="zur" /locus_tag="BSU_25100" /old_locus_tag="BSU25100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12180919, 12426338, 12904577, 17216355, 21821657, 25213752, 27561249, 28104400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12180919, 12426338, 12904577, 17216355, 21821657, 25213752, 27561249, 28104400; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Zn[2+]-binding Fur family)" /protein_id="NP_390389.2" /db_xref="EnsemblGenomes-Gn:BSU25100" /db_xref="EnsemblGenomes-Tr:CAB14440" /db_xref="GOA:P54479" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11668" /db_xref="UniProtKB/Swiss-Prot:P54479" /translation="MNVQEALNLLKENGYKYTNKREDMLQLFADSDRYLTAKNVLSAL NDDYPGLSFDTIYRNLSLYEELGILETTELSGEKLFRFKCSFTHHHHHFICLACGKTK EIESCPMDKLCDDLDGYQVSGHKFEIYGTCPDCTAENQENTTA*" /label="zur CDS" gene complement(2190357..2190794) /gene="zur" /locus_tag="BSU_25100" /old_locus_tag="BSU25100" /label="zur gene" downshifts complement(2190361) /Source="Nicolas_upshifts" /id="D1302" /incds=0 /nref=181 /ntot=243 /MaxReadThrough="2.37371" /MaxDrop="6.74703" /score="16.4418277" /energy="-11.9" /TU="U1956" /idTUdmin="U1952" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2190795..2190889) /Source="Nicolas_S_feature" /locus_tag="new_2591866_2591960_c" /HighExp="LPhT, G180, Cold, LBGstat, H2O2, Oxctl, G135, G150, HPh, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S942" promotor_-10 complement(2190885..2190904) /Source="Nicolas_upshift_promotors" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2190889) /Source="Nicolas_upshifts" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2190919..2190926) /Source="Nicolas_upshift_promotors" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2190932..2191813) /gene="yqfU" /locus_tag="BSU_25110" /old_locus_tag="BSU25110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390390.2" /db_xref="EnsemblGenomes-Gn:BSU25110" /db_xref="EnsemblGenomes-Tr:CAB14441" /db_xref="GOA:P54478" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG11667" /db_xref="UniProtKB/Swiss-Prot:P54478" /translation="MTPTKQHKKETFTHFIFRVFMILVGAASAAVSIELFLIPNDFID GGIIGVSLILDHLFMSNPFLNFAFFVVILNIPFMIFGYKYIGKTFLVSTFIGIVGLAV IESSLHHVEAITTQPILATVFGGLLLGFGVGLVIRNGGSMDGTEILGILLTKKLPFSV GEFVMFINVFIFIWAVFVFGPEQAMYSFMTYYIAMKTIDAVIQGLDETKAVIIVSEQY DEISDAILHRLGRGTTKLKGKGGYTDEEKDVIYAVVTRLEVTKLKSIVFEVDQNAFIT IMNTHETRGGKFKNAIH*" /label="yqfU CDS" gene complement(2190932..2191813) /gene="yqfU" /locus_tag="BSU_25110" /old_locus_tag="BSU25110" /label="yqfU gene" promotor_-35 2191809..2191814 /Source="Nicolas_upshift_promotors" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2191830..2191848 /Source="Nicolas_upshift_promotors" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2191846 /Source="Nicolas_upshifts" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2191851..2191870) /Source="Nicolas_upshift_promotors" /id="U1954" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2995 /SigmaFactorBS="cctccagacttaatgtatgggcaaatcagtaaaatgtgtcag tgtttAATGGTAAAATAGATTTATAatgtatttaaaatagttattgcaggaaaggaga t" /listShort="yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2191857) /Source="Nicolas_upshifts" /id="U1954" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2995 /SigmaFactorBS="cctccagacttaatgtatgggcaaatcagtaaaatgtgtcag tgtttAATGGTAAAATAGATTTATAatgtatttaaaatagttattgcaggaaaggaga t" /listShort="yqfU, S942, zur" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2191859..2192186) /Source="Nicolas_S_feature" /locus_tag="new_2592930_2593257_c" /HighExp="Cold, T-4.40H, T-5.40H, Salt, GM-0.1, BMM, UNK1, MG 25, GM-0.2, SMM" /AntisenseName="yqfT" /AntisenseCor="-0.62379514374156597" /AntisenseRegPval="-29.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S943" promotor_-35 2191875..2191884 /Source="Nicolas_upshift_promotors" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2191891 /Source="Nicolas_upshifts" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2191897..2191916 /Source="Nicolas_upshift_promotors" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2191929..2192183 /gene="yqfT" /locus_tag="BSU_25120" /old_locus_tag="BSU25120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390391.1" /db_xref="EnsemblGenomes-Gn:BSU25120" /db_xref="EnsemblGenomes-Tr:CAB14442" /db_xref="InterPro:IPR020277" /db_xref="SubtiList:BG11666" /db_xref="UniProtKB/Swiss-Prot:P54477" /translation="MILFQRIILQRLNQATADDLLKYSKQYGISLTRSQAVEVANLLY GKNVNIFNESERMRLLKQVETITSKETAQTVNELFKQFTS*" /label="yqfT CDS" gene 2191929..2192183 /gene="yqfT" /locus_tag="BSU_25120" /old_locus_tag="BSU25120" /label="yqfT gene" downshifts 2192170 /Source="Nicolas_upshifts" /id="D1303" /incds=0 /nref=12 /ntot=72 /MaxReadThrough="3.97414" /MaxDrop="7.03976" /score="24.5413663" /energy="-9.8" /TU="U1953" /idTUdmin="U1955" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2192210..2193103) /gene="nfo" /locus_tag="BSU_25130" /old_locus_tag="BSU25130" /EC_number="3.1.21.2" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12486072, 12949090, 16237020, 18203828, 19930460, 21441501, 24123749, 24244006, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486072, 12949090, 16237020, 18203828, 19930460, 21441501, 24123749, 24244006, 24914186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type IV apurinic/apyrimidinic endonuclease" /protein_id="NP_390392.1" /db_xref="EnsemblGenomes-Gn:BSU25130" /db_xref="EnsemblGenomes-Tr:CAB14443" /db_xref="GOA:P54476" /db_xref="InterPro:IPR001719" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR018246" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11665" /db_xref="UniProtKB/Swiss-Prot:P54476" /translation="MLRIGSHVSMSGKHMLLAASQEAVSYGANTFMIYTGAPQNTRRK KIEDLNIEAGRAHMQENGIDEIIVHAPYIINIGNTTNPSTFELGVDFLRSEIERTAAI GAKQIVLHPGAHVGAGAEAGIKKIIEGLNEVIDPNQNVQIALETMAGKGSECGRSFEE LAQIIEGVTHNEQLSVCFDTCHTHDAGYNIVEDFDGVLNEFDKIIGIDRIKVLHINDS KNVKGARKDRHENIGFGEIGFDALQYVVHHEQLKDIPKILETPYVGEDKKNKKPPYRF EIEMLKEKQFDDTLLEKILQQ*" /label="nfo CDS" gene complement(2192210..2193103) /gene="nfo" /locus_tag="BSU_25130" /old_locus_tag="BSU25130" /label="nfo gene" S_feature 2192215..2193016 /Source="Nicolas_S_feature" /locus_tag="new_2593286_2594087" /HighExp="S6, S7, C30, S8, S5, G135, C90, Gly, LoTm, Sw" /AntisenseName="nfo" /AntisenseCor="-0.36683479556464399" /AntisenseRegPval="-9.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S944" downshifts complement(2192231) /Source="Nicolas_upshifts" /id="D1304" /incds=0 /nref=46 /ntot=187 /MaxReadThrough="4.82641" /MaxDrop="6.05328" /score="16.7756411" /energy="-9.8" /TU="U1956" /idTUdmin="U1952" /TUdmin="-1870" /isTUend="FALSE" /label="downshifts" CDS complement(2193113..2194429) /gene="cshB" /locus_tag="BSU_25140" /old_locus_tag="BSU25140" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 16352840, 18203828, 20572937, 23175651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 16352840, 18203828, 20572937, 23175651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase; cold shock" /protein_id="NP_390393.1" /db_xref="EnsemblGenomes-Gn:BSU25140" /db_xref="EnsemblGenomes-Tr:CAB14444" /db_xref="GOA:P54475" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030881" /db_xref="SubtiList:BG11664" /db_xref="UniProtKB/Swiss-Prot:P54475" /translation="MKETKFELYELKPFIIDAVHRLGFYEPTDIQKRLIPAVLKKESV IGQSQTGTGKTHAYLLPLLNKIDPAKDVVQVVITAPTRELANQIYQEALKITQGEEGS QIRSKCFIGGTDKQKSIDKLKIQPHLVVGTPGRIADLIKEQALSVHKAESLVIDEADL MLDMGFLADVDYIGSRMPEDLQMLVFSATIPEKLKPFLKKYMENPKYAHVEPKQVTAA KIEHILIPSKHRDKDKLLFDIMSHLNPYLGIVFANTKNTADHIAQYLTGKGMKIGLLH GGLTPRERKKVMKQINDLEFTYIIATDLAARGIDIKGVSHVINYELPDDLDFYVHRVG RTARAGSSGQAMTIYELTDEDALVRLEKMGIEFEYLELEKGEWKKGDDRQRRKKRKKT PNEADEIAHRLVKKPKKVKPGYKKKMSYEMEKIKKKQRRNQSKKRK*" /label="cshB CDS" gene complement(2193113..2194429) /gene="cshB" /locus_tag="BSU_25140" /old_locus_tag="BSU25140" /label="cshB gene" promotor_-10 complement(2194465..2194484) /Source="Nicolas_upshift_promotors" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2194476) /Source="Nicolas_upshifts" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2194500..2194504) /Source="Nicolas_upshift_promotors" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2194533..2194542 /Source="Nicolas_upshift_promotors" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2194554 /Source="Nicolas_upshifts" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2194556..2194575 /Source="Nicolas_upshift_promotors" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2194598..2195341 /gene="yqfQ" /locus_tag="BSU_25150" /old_locus_tag="BSU25150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390394.1" /db_xref="EnsemblGenomes-Gn:BSU25150" /db_xref="EnsemblGenomes-Tr:CAB14445" /db_xref="InterPro:IPR025571" /db_xref="SubtiList:BG11663" /db_xref="UniProtKB/Swiss-Prot:P54474" /translation="MFSPQQPMRNYPQPGPPRPMPNQRMMGRRPPNMRGPSFGAQQQG FQQAGQFLPQANAGARNGAGAGGGLKGMLSRFLPGGGGAGSAGVPGIPGAGAAASGGA GLQGIQNIANPASLSSMLGNVQKVLGMAQQVTPMIQQYGPLVRNLPAMMKLYSQLSKS DDTETEANEESEKQSVSEESSEKEKETETKTSDGNKKSKPKSSSLPKKSKTTDNKEQE LKTSAPKKKEAASPAPKRTSGSSKPRLYI*" /label="yqfQ CDS" gene 2194598..2195341 /gene="yqfQ" /locus_tag="BSU_25150" /old_locus_tag="BSU25150" /label="yqfQ gene" downshifts 2195323 /Source="Nicolas_upshifts" /id="D1305" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="5.46594" /MaxDrop="3.2445" /score="4.32537428" /energy="-6.8" /TU="U1957" /idTUdmin="U1957" /TUdmin="-1056" /isTUend="FALSE" /label="downshifts" promotor_-35 2195345..2195352 /Source="Nicolas_upshift_promotors" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2195366..2195385 /Source="Nicolas_upshift_promotors" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2195368..2195463 /Source="Nicolas_S_feature" /locus_tag="new_2596439_2596534" /HighExp="S8, S7, S6, Cold, H2O2, Salt, dia15, G180, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S945" upshifts 2195368 /Source="Nicolas_upshifts" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="upshifts" CDS 2195464..2196408 /gene="ispH" /locus_tag="BSU_25160" /old_locus_tag="BSU25160" /EC_number="1.17.7.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12706830, 15381396, 15469281, 17458547, 27169371; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase" /protein_id="NP_390395.2" /db_xref="EnsemblGenomes-Gn:BSU25160" /db_xref="EnsemblGenomes-Tr:CAB14446" /db_xref="GOA:P54473" /db_xref="InterPro:IPR003451" /db_xref="SubtiList:BG11662" /db_xref="UniProtKB/Swiss-Prot:P54473" /translation="MDVIKISPRGYCYGVVDAMVIAKNASLDKSLPRPIYILGMIVHN KHVTDAFEEEGIFTLDGSNRLDILKQVDKGTVIFTAHGVSPEVRRIAEEKGLVAIDAT CPDVTKTHNLILEMKEKGYHVIYIGKKGHPEPEGAVGVAPEIVHLVETEEDVKNLDIQ SEKLIVTNQTTMSQWDVHDIMELVKEKYPHVEYHQEICLATQVRQEAVSEQAKKADLT IVVGDPKSNNSNRLAQVSEEIAGTKAYRIGDLSELKLEWLKGVNTVAVTAGASTPTPI TKEVIRFLEQFDHEDPSTWTTEHNIPLKKILPKVKAKN*" /label="ispH CDS" gene 2195464..2196408 /gene="ispH" /locus_tag="BSU_25160" /old_locus_tag="BSU25160" /label="ispH gene" downshifts 2196379 /Source="Nicolas_upshifts" /id="D1306" /incds=0 /nref=106 /ntot=243 /MaxReadThrough="4.04288" /MaxDrop="5.66904" /score="29.529951" /energy="-12.2" /TU="U1958" /idTUdmin="U1957" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2196431..2197552) /gene="yqfO" /locus_tag="BSU_25170" /old_locus_tag="BSU25170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17187687, 17586767; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative GTP cyclohydrolase" /protein_id="NP_390396.1" /db_xref="EnsemblGenomes-Gn:BSU25170" /db_xref="EnsemblGenomes-Tr:CAB14447" /db_xref="GOA:P54472" /db_xref="InterPro:IPR002678" /db_xref="InterPro:IPR015867" /db_xref="InterPro:IPR017221" /db_xref="InterPro:IPR036069" /db_xref="SubtiList:BG11661" /db_xref="UniProtKB/Swiss-Prot:P54472" /translation="MAKSVNGQQIIQLFEQFSPKAYAVEGDKIGLQIGTLNKPIKNVM VTLDVLESVIDEAIEKEVDLIIAHHPPIFRSLKHISTDQPAGRLIEKCLKHDIAVYAA HTNLDVADGGVNDLLAEALELSETEVLAPTYTDPLKKLAVYVPKEYEEQVRAALGNAG AGHIGEYSHCAFSSEGIGSFKPLDGAKPFIGEVGELELVHEVRLETVFPKSVEKAVIN AMIKSHPYEEVAYDIYPVEQTPAEKGLGRVGTLKNEMTLKEFALFVKDKLDVNGVRMV GDADSMVKKVAVLGGDGNKYIHHAKRKGADVYVTGDLYFHVAHDAMMLGLNVVDPGHY AEKIMKEGVTRKLTSMCNDKKFGVNIFVSETDTNPFTFL*" /label="yqfO CDS" gene complement(2196431..2197552) /gene="yqfO" /locus_tag="BSU_25170" /old_locus_tag="BSU25170" /label="yqfO gene" downshifts complement(2196456) /Source="Nicolas_upshifts" /id="D1307" /incds=0 /nref=63 /ntot=224 /MaxReadThrough="3.241" /MaxDrop="4.76436" /score="27.9821938" /energy="-12.2" /TU="NA" /idTUdmin="U1959" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2197545..2198195) /gene="trmK" /locus_tag="BSU_25180" /old_locus_tag="BSU25180" /EC_number="2.1.1.217" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:18420655, 27098549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18420655, 27098549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (adenine(22)-N(1))-methyltransferase" /protein_id="NP_390397.1" /db_xref="EnsemblGenomes-Gn:BSU25180" /db_xref="EnsemblGenomes-Tr:CAB14448" /db_xref="GOA:P54471" /db_xref="InterPro:IPR006901" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11660" /db_xref="UniProtKB/Swiss-Prot:P54471" /translation="MADIGSDHAYLPCYAVLNHKASGAIAGEITDGPFLSAKRQVEKS GLNSHISVRQGDGLEVIKKGEADAITIAGMGGALIAHILEAGKDKLTGKERLILQPNI HAVHIREWLYKERYALIDEVILEEDGKCYEVLVAEAGDRDAAYDGISLSAGMLVGPFL AKEKNAVFLKKWTQELQHTQSIYEQISQAADTEQNKQKLKELADRMELLKEVIDHG*" /label="trmK CDS" gene complement(2197545..2198195) /gene="trmK" /locus_tag="BSU_25180" /old_locus_tag="BSU25180" /label="trmK gene" S_feature complement(2198196..2198304) /Source="Nicolas_S_feature" /locus_tag="new_2599267_2599375_c" /HighExp="LBGexp, LBGtran, dia15, dia0, Lbexp, G150, G180, LBGstat, Oxctl, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.98, 0.998" /TUlongSig="SigH, SigEF, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="1, 0.974, 0.979, 1, 1, 0.999, 0.998" /label="S946" promotor_-10 complement(2198292..2198311) /Source="Nicolas_upshift_promotors" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2198304) /Source="Nicolas_upshifts" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2198306..2198419) /Source="Nicolas_S_feature" /locus_tag="new_2599377_2599490_c" /HighExp="Lbstat, M0t90, M9-stat, S2, T1.0H, T1.30H, T2.30H, T3.0H, S7, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.98, 0.998" /TUlongSig="SigH, SigEF, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="1, 0.974, 0.979, 1, 1, 0.999, 0.998" /label="S947" promotor_-35 complement(2198327..2198331) /Source="Nicolas_upshift_promotors" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2198452..2198814) /gene="cccA" /locus_tag="BSU_25190" /old_locus_tag="BSU25190" /function="16.7: Manage energy" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10024472, 10473570, 11361075, 15995641, 19222757" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10024472, 10473570, 11361075, 15995641, 19222757; Product type c: carrier" /codon_start=1 /transl_table=11 /product="cytochrome c550" /protein_id="NP_390398.1" /db_xref="EnsemblGenomes-Gn:BSU25190" /db_xref="EnsemblGenomes-Tr:CAB14449" /db_xref="GOA:P24469" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012218" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG10315" /db_xref="UniProtKB/Swiss-Prot:P24469" /translation="MKWNPLIPFLLIAVLGIGLTFFLSVKGLDDSREIASGGESKSAE KKDANASPEEIYKANCIACHGENYEGVSGPSLKGVGDKKDVAEIKTKIEKGGNGMPSG LVPADKLDDMAEWVSKIK*" /label="cccA CDS" gene complement(2198452..2198814) /gene="cccA" /locus_tag="BSU_25190" /old_locus_tag="BSU25190" /label="cccA gene" downshifts complement(2198464) /Source="Nicolas_upshifts" /id="D1308" /incds=0 /nref=3 /ntot=88 /MaxReadThrough="4.32389" /MaxDrop="3.4795" /score="-4.13120914" /energy="-7.6" /TU="U1961,U1962" /idTUdmin="U1968" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-35 2198810..2198814 /Source="Nicolas_upshift_promotors" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2198822..2198836 /Source="Nicolas_upshift_promotors" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2198843 /Source="Nicolas_upshifts" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2198851..2198870) /Source="Nicolas_upshift_promotors" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2198853) /Source="Nicolas_upshifts" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2198855..2198976) /Source="Nicolas_S_feature" /locus_tag="new_2599926_2600047_c" /HighExp="Lbstat, T3.0H, T1.30H, M9-stat, T2.30H, T1.0H, T2.0H, T3.30H, M0t90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="0.998, 1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S948" promotor_-35 complement(2198882..2198889) /Source="Nicolas_upshift_promotors" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2198965..2198984) /Source="Nicolas_upshift_promotors" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2198973..2198992 /Source="Nicolas_upshift_promotors" /id="U1963" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=360 /SigmaFactorBS="ctttatacaaaattgaatagaaacatgcctaaatctcTaata tcctttttattcTATTGTATAATGTATTGTATacgcttacaatagaaaatatggaatt a" /listShort="S950, S951" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2198976) /Source="Nicolas_upshifts" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2198978..2199117) /Source="Nicolas_S_feature" /locus_tag="new_2600049_2600188_c" /HighExp="Lbstat, S8, S1, S7, G/S, BT, Mal, Gly, S6, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S949" S_feature 2198979..2199083 /Source="Nicolas_S_feature" /locus_tag="new_2600050_2600154" /HighExp="T2.30H, M9-stat, T3.0H, T1.30H, T2.0H, T1.0H, T3.30H, T4.0H, M0t90, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S950" upshifts 2198979 /Source="Nicolas_upshifts" /id="U1963" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=360 /SigmaFactorBS="ctttatacaaaattgaatagaaacatgcctaaatctcTaata tcctttttattcTATTGTATAATGTATTGTATacgcttacaatagaaaatatggaatt a" /listShort="S950, S951" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2198998..2199004) /Source="Nicolas_upshift_promotors" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2199047..2199054 /Source="Nicolas_upshift_promotors" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2199068..2199087 /Source="Nicolas_upshift_promotors" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2199085..2201234 /Source="Nicolas_S_feature" /locus_tag="new_2600156_2602305" /HighExp="S2, T4.0H, T5.0H, Lbstat, M9-stat, T3.30H, S8, T3.0H, C30, T2.0H" /AntisenseName="sigA" /AntisenseCor="-0.16938350693676901" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S951" upshifts 2199085 /Source="Nicolas_upshifts" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2199143..2200258) /gene="sigA" /locus_tag="BSU_25200" /old_locus_tag="BSU25200" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12455702, 12682299, 14527287, 15060039, 15670950, 28648455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12455702, 12682299, 14527287, 15060039, 15670950, 28648455; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA polymerase major sigma-43 factor (sigma-A)" /protein_id="NP_390399.2" /db_xref="EnsemblGenomes-Gn:BSU25200" /db_xref="EnsemblGenomes-Tr:CAB14450" /db_xref="GOA:P06224" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007127" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR009042" /db_xref="InterPro:IPR012760" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR028630" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10314" /db_xref="UniProtKB/Swiss-Prot:P06224" /translation="MADKQTHETELTFDQVKEQLTESGKKRGVLTYEEIAERMSSFEI ESDQMDEYYEFLGEQGVELISENEETEDPNIQQLAKAEEEFDLNDLSVPPGVKINDPV RMYLKEIGRVNLLSAKEEIAYAQKIEEGDEESKRRLAEANLRLVVSIAKRYVGRGMLF LDLIQEGNMGLMKAVEKFDYRKGYKFSTYATWWIRQAITRAIADQARTIRIPVHMVET INKLIRVQRQLLQDLGREPTPEEIAEDMDLTPEKVREILKIAQEPVSLETPIGEEDDS HLGDFIEDQEATSPSDHAAYELLKEQLEDVLDTLTDREENVLRLRFGLDDGRTRTLEE VGKVFGVTRERIRQIEAKALRKLRHPSRSKRLKDFLE*" /label="sigA CDS" gene complement(2199143..2200258) /gene="sigA" /locus_tag="BSU_25200" /old_locus_tag="BSU25200" /label="sigA gene" downshifts complement(2199162) /Source="Nicolas_upshifts" /id="D1309" /incds=0 /nref=118 /ntot=198 /MaxReadThrough="4.93947" /MaxDrop="6.16048" /score="4.75833607" /energy="-11.7" /TU="U1966,U1968,U1969,U1970,U1972,U1973" /idTUdmin="U1970" /TUdmin="-287" /isTUend="FALSE" /label="downshifts" S_feature complement(2200259..2200456) /Source="Nicolas_S_feature" /locus_tag="new_2601330_2601527_c" /HighExp="BC, Cold, SMMPr, S1, BI, G135, C30, Lbstat, S5, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S952" CDS complement(2200457..2202268) /gene="dnaG" /locus_tag="BSU_25210" /old_locus_tag="BSU25210" /EC_number="2.7.7.-" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3100394, 9387153, 12682299, 16036556, 28386108; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA primase" /protein_id="NP_390400.2" /db_xref="EnsemblGenomes-Gn:BSU25210" /db_xref="EnsemblGenomes-Tr:CAB14451" /db_xref="GOA:P05096" /db_xref="InterPro:IPR002694" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR006295" /db_xref="InterPro:IPR013264" /db_xref="InterPro:IPR016136" /db_xref="InterPro:IPR019475" /db_xref="InterPro:IPR030846" /db_xref="InterPro:IPR034151" /db_xref="InterPro:IPR036185" /db_xref="InterPro:IPR036977" /db_xref="InterPro:IPR037068" /db_xref="PDB:5GUJ" /db_xref="SubtiList:BG10313" /db_xref="UniProtKB/Swiss-Prot:P05096" /translation="MGNRIPDEIVDQVQKSADIVEVIGDYVQLKKQGRNYFGLCPFHG ESTPSFSVSPDKQIFHCFGCGAGGNVFSFLRQMEGYSFAESVSHLADKYQIDFPDDIT VHSGARPESSGEQKMAEAHELLKKFYHHLLINTKEGQEALDYLLSRGFTKELINEFQI GYALDSWDFITKFLVKRGFSEAQMEKAGLLIRREDGSGYFDRFRNRVMFPIHDHHGAV VAFSGRALGSQQPKYMNSPETPLFHKSKLLYNFYKARLHIRKQERAVLFEGFADVISA VSSDVKESIATMGTSLTDDHVKILRRNVEEIILCYDSDKAGYEATLKASELLQKKGCK VRVAMIPDGLDPDDYIKKFGGEKFKNDIIDASVTVMAFKMQYFRKGKNLSDEGDRLAY IKDVLKEISTLSGSLEQEVYVKQLASEFSLSQESLTEQLSVFSKQNKPADNSGETKTR RAHLTTKARQKRLRPAYENAERLLLAHMLRDRSVIKKVIDRVGFQFNIDEHRALAAYL YAFYEEGAELTPQHLMARVTDDHISQLLSDILMLQVNQELSEAELSDYVKKVLNQRNW SMIKEKEAERAEAERQKDFLRAASLAQEIVTLNRSLK*" /label="dnaG CDS" gene complement(2200457..2202268) /gene="dnaG" /locus_tag="BSU_25210" /old_locus_tag="BSU25210" /label="dnaG gene" promotor_-35 2201863..2201869 /Source="Nicolas_upshift_promotors" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2201879 /Source="Nicolas_upshifts" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2201881..2201900 /Source="Nicolas_upshift_promotors" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2201908..2202204 /gene="antE" /locus_tag="BSU_25220" /old_locus_tag="BSU25220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 9864351" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_054587.1" /db_xref="EnsemblGenomes-Gn:BSU25220" /db_xref="EnsemblGenomes-Tr:CAE01462" /db_xref="GOA:Q7WY63" /db_xref="SubtiList:BG14178" /db_xref="UniProtKB/Swiss-Prot:Q7WY63" /translation="MPQPFFVLQKTLAGLRNGLLYHLENQFGICQQGEKPTRQKNSLP SALKKRKHCRPLRSQSNEKSVCRAIRKTKVCFLHEKDRVQSSFGLASLIEHNHL*" /label="antE CDS" gene 2201908..2202204 /gene="antE" /locus_tag="BSU_25220" /old_locus_tag="BSU25220" /label="antE gene" CDS complement(2202302..2202796) /gene="yqxD" /locus_tag="BSU_25230" /old_locus_tag="BSU25230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 9387153, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390401.2" /db_xref="EnsemblGenomes-Gn:BSU25230" /db_xref="EnsemblGenomes-Tr:CAB14452" /db_xref="InterPro:IPR003791" /db_xref="SubtiList:BG10312" /db_xref="UniProtKB/Swiss-Prot:P17868" /translation="MEGWRITLLNEQEKTIFVDADACPVKDEILQTASEYEVQVLFVA SFEHYQLSRSNEEKWKYVDPHKEAADLYIANHVKPGDIVVTQDIGLASLLLNRNVSVM SERGRLYKEDTIDFALEGRHFSGKQRRKGVYAKGPKKLNKEDRERFITLLQKILSNDE GILH*" /label="yqxD CDS" gene complement(2202302..2202796) /gene="yqxD" /locus_tag="BSU_25230" /old_locus_tag="BSU25230" /label="yqxD gene" promotor_-10 complement(2202769..2202787) /Source="Nicolas_upshift_promotors" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2202780) /Source="Nicolas_upshifts" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" S_feature complement(2202797..2202910) /Source="Nicolas_S_feature" /locus_tag="new_2603868_2603981_c" /HighExp="S5, S4, S6, S7, S8, S3, Etha, dia15, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S953" promotor_-35 complement(2202799..2202807) /Source="Nicolas_upshift_promotors" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-35 2202805..2202810 /Source="Nicolas_upshift_promotors" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2202826..2202844 /Source="Nicolas_upshift_promotors" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2202841 /Source="Nicolas_upshifts" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2202895..2202913) /Source="Nicolas_upshift_promotors" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2202910) /Source="Nicolas_upshifts" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" S_feature complement(2202912..2202989) /Source="Nicolas_S_feature" /locus_tag="new_2603983_2604060_c" /HighExp="Etha, G180, G135, G150, LBGtran, LBGexp, dia15, H2O2, Oxctl, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S954" promotor_-35 complement(2202929..2202934) /Source="Nicolas_upshift_promotors" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-10 complement(2202955..2202974) /Source="Nicolas_upshift_promotors" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2202989) /Source="Nicolas_upshifts" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2202990..2202993) /Source="Nicolas_upshift_promotors" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2203050..2203862) /gene="ppsR" /locus_tag="BSU_25240" /old_locus_tag="BSU25240" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15720552, 20044937" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15720552, 20044937; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional ADP-dependent kinase-Pi-dependent pyrophosphorylase / positive regulator of gluconeogenesis" /protein_id="NP_390402.1" /db_xref="EnsemblGenomes-Gn:BSU25240" /db_xref="EnsemblGenomes-Tr:CAB14453" /db_xref="GOA:P54470" /db_xref="InterPro:IPR005177" /db_xref="InterPro:IPR026565" /db_xref="SubtiList:BG11659" /db_xref="UniProtKB/Swiss-Prot:P54470" /translation="MNNRIIYVVSDSVGETAELVVKAALSQFNGSADDTHVRRIPYVE DIGTINEVISLAKADGGIICFTLVVPEIREYLIAEAEKANVLYYDIIGPLIDKMETAY GLTAKYEPGRVRQLDEDYFKKVEAIEFAVKYDDGRDPRGILKADIVLIGVSRTSKTPL SQYLAHKRLKVANVPIVPEVDPPEELFNVDPKKCIGLKISPDKLNHIRKERLKSLGLN DKAIYANINRIKEELEYFEKIVDRIGCQVVDVSNKAVEETANIIHHLKTKNI*" /label="ppsR CDS" gene complement(2203050..2203862) /gene="ppsR" /locus_tag="BSU_25240" /old_locus_tag="BSU25240" /label="ppsR gene" CDS complement(2203888..2204526) /gene="ccpN" /locus_tag="BSU_25250" /old_locus_tag="BSU25250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15720552, 17011578, 17962296, 18511073, 18586936, 19202299, 19726675, 28178965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15720552, 17011578, 17962296, 18511073, 18586936, 19202299, 19726675, 28178965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of gluconeogenesis" /protein_id="NP_390403.1" /db_xref="EnsemblGenomes-Gn:BSU25250" /db_xref="EnsemblGenomes-Tr:CAB14454" /db_xref="GOA:O34994" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016842" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3FV6" /db_xref="PDB:3FWR" /db_xref="PDB:3FWS" /db_xref="SubtiList:BG13768" /db_xref="UniProtKB/Swiss-Prot:O34994" /translation="MSTIELNKRQEHILQIVKENGPITGEHIAEKLNLTRATLRPDLA ILTMSGFLEARPRVGYFYTGKTGTQLLADKLKKLQVKDFQSIPVVIHENVSVYDAICT MFLEDVGTLFVVDRDAVLVGVLSRKDLLRASIGQQELTSVPVHIIMTRMPNITVCRRE DYVMDIAKHLIEKQIDALPVIKDTDKGFEVIGRVTKTNMTKILVSLSENEIL*" /label="ccpN CDS" gene complement(2203888..2204526) /gene="ccpN" /locus_tag="BSU_25250" /old_locus_tag="BSU25250" /label="ccpN gene" S_feature complement(2204527..2204658) /Source="Nicolas_S_feature" /locus_tag="new_2605598_2605729_c" /HighExp="G135, dia5, G180, G150, dia15, H2O2, LBGexp, Lbexp, Oxctl, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 1, 0.999, 0.998" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S955" promotor_-10 complement(2204652..2204671) /Source="Nicolas_upshift_promotors" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-10" CDS complement(2204659..2206698) /gene="glyS" /locus_tag="BSU_25260" /old_locus_tag="BSU25260" /EC_number="6.1.1.14" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15890195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycyl-tRNA synthetase (beta subunit)" /protein_id="NP_390404.2" /db_xref="EnsemblGenomes-Gn:BSU25260" /db_xref="EnsemblGenomes-Tr:CAB14455" /db_xref="GOA:P54381" /db_xref="InterPro:IPR006194" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR015944" /db_xref="SubtiList:BG11658" /db_xref="UniProtKB/Swiss-Prot:P54381" /translation="MSKQDLLLEIGLEEMPARFLNESMVQLGDKLTGWLKEKNITHGE VKLFNTPRRLAVFVKDVAEKQDDIKEEAKGPAKKIALDADGNWTKAAIGFSKGQGANV EDLYIKEVKGIEYVFVQKFQAGQETKSLLPELSGLITSLHFPKNMRWGNEDLRYIRPI KWIVALFGQDVIPFSITNVESGRTTQGHRFLGHEVSIESPSAYEEQLKGQHVIADPSV RKQMIQSQLETMAAENNWSIPVDEDLLDEVNHLVEYPTALYGSFESEFLSIPEEVLVT TMKEHQRYFPVKDKNGDLLPHFITVRNGNSHAIENVARGNEKVLRARLSDASFFYKED QKLNIDANVKKLENIVFHEELGSLADKVRRVTSIAEKLAVRLQADEDTLKHVKRAAEI SKFDLVTHMIYEFPELQGIMGEKYARMLGEDEAVAAAVNEHYMPRSAGGETPSTFTGA VVAMADKLDTIASFFSIGVIPTGSQDPYGLRRQASGIVAILLDRNWGISFEELLTFVQ TDKENELLDFFTQRLKYVLNAEQIRHDVIDAVLESSELEPYSALHKAQVLEQKLGAPG FKETAEALGRVISISKKGVRGDIQPDLFENEYEAKLFDAYQTAKQNLQENFSKKDYEA ALASLAALKEPIDAYFDHTMVIADNESLKANRLAQMVSLADEIKSFANMNALIVK*" /label="glyS CDS" gene complement(2204659..2206698) /gene="glyS" /locus_tag="BSU_25260" /old_locus_tag="BSU25260" /label="glyS gene" upshifts complement(2204661) /Source="Nicolas_upshifts" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2204686..2204693) /Source="Nicolas_upshift_promotors" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-35" downshifts complement(2204705) /Source="Nicolas_upshifts" /id="D1310" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="6.14024" /MaxDrop="3.62589" /score="-9.01330408" /energy="-8.2" /TU="U1972,U1973,U1975" /idTUdmin="U1975" /TUdmin="-1320" /isTUend="FALSE" /label="downshifts" downshifts complement(2204771) /Source="Nicolas_upshifts" /id="D1311" /incds=1 /nref=10 /ntot=162 /MaxReadThrough="6.17154" /MaxDrop="3.30313" /score="-9.01330408" /energy="-8.2" /TU="U1972,U1973,U1975" /idTUdmin="U1975" /TUdmin="-1386" /isTUend="FALSE" /label="downshifts" CDS complement(2206691..2207578) /gene="glyQ" /locus_tag="BSU_25270" /old_locus_tag="BSU25270" /EC_number="6.1.1.14" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15890195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycyl-tRNA synthetase (alpha subunit)" /protein_id="NP_390405.1" /db_xref="EnsemblGenomes-Gn:BSU25270" /db_xref="EnsemblGenomes-Tr:CAB14456" /db_xref="GOA:P54380" /db_xref="InterPro:IPR002310" /db_xref="InterPro:IPR006194" /db_xref="SubtiList:BG11657" /db_xref="UniProtKB/Swiss-Prot:P54380" /translation="MNIQDMILTLQKHWSSQGCVLMQAYDVEKGAGTMSPYTFLRSIG PEPWKVAYVEPSRRPADGRYGENPNRLYQHHQFQVIIKPSPDNIQELYLDSLRALGID PLEHDIRFVEDNWENPSLGCAGLGWEVWLDGMEITQFTYFQQVGGLECKPVSVEITYG IERLASYIQDKENVFDLEWTSGFTVKDLFMMAEYEHSVYTFETSDVDMLFQLFSTYEK EAIKQMDNGLVHPAYDYVLKCSHTFNLLDAKGAISVTERTGYIARVRNLARKVAKTYY EEREKLGFPMLKGEGSSHE*" /label="glyQ CDS" gene complement(2206691..2207578) /gene="glyQ" /locus_tag="BSU_25270" /old_locus_tag="BSU25270" /label="glyQ gene" misc_RNA complement(2207661..2207835) /gene="tboG" /locus_tag="BSU_misc_RNA_39" /product="T-box riboswitch controlling synthesis of glycine-tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201, 15890195, 26229106" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201, 15890195, 26229106; Product type n : RNA" /label="tboG RNA" gene complement(2207661..2207835) /gene="tboG" /locus_tag="BSU_misc_RNA_39" /label="tboG gene" downshifts complement(2207695) /Source="Nicolas_upshifts" /id="D1312" /incds=0 /nref=70 /ntot=220 /MaxReadThrough="6.60948" /MaxDrop="5.42847" /score="18.9025126" /energy="-23.3" /TU="U1972,U1973,U1975" /idTUdmin="U1976" /TUdmin=178 /isTUend="FALSE" /label="downshifts" promotor_-35 2207810..2207815 /Source="Nicolas_upshift_promotors" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2207831..2207849 /Source="Nicolas_upshift_promotors" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2207839..2207858) /Source="Nicolas_upshift_promotors" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" S_feature 2207841..2209253 /Source="Nicolas_S_feature" /locus_tag="new_2608912_2610324" /HighExp="C30, S8, Gly, BT, G135, Fru, S6, C90, Lbstat, Mal" /AntisenseName="recO" /AntisenseCor="0.22892689952134901" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.955" /TUlongSig="NA" /TUlongPSig="NA" /label="S956" upshifts 2207841 /Source="Nicolas_upshifts" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2207851) /Source="Nicolas_upshifts" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2207873..2207880) /Source="Nicolas_upshift_promotors" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2207875..2208642) /gene="recO" /locus_tag="BSU_25280" /old_locus_tag="BSU25280" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10323239, 15186413, 16061691, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10323239, 15186413, 16061691, 26001966; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA double strand break repair and homologous recombination factor" /protein_id="NP_390406.2" /db_xref="EnsemblGenomes-Gn:BSU25280" /db_xref="EnsemblGenomes-Tr:CAB14457" /db_xref="GOA:P42095" /db_xref="InterPro:IPR003717" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022572" /db_xref="SubtiList:BG11189" /db_xref="UniProtKB/Swiss-Prot:P42095" /translation="MLTKCEGIVLRTNDYGETNKIVTLLTREHGKIGVMARGAKKPNS RLSAVSQPFLYGSFLMQKTSGLGTLQQGEMILSMRGIREDLFLTAYAAYVAELVDRGT EEKKPNPYLFEFILESLKQLNEGTDPDVITFIVQMKMLGVMGLYPELNHCVHCKSQDG TFHFSVRDNGFICHRCFEKDPYRIPIKPQTARLLRLFYYFDLSRLGNVSLKEETKAEL KQVIDLYYEEYSGLYLKSKRFLDQMESMKHLMGENKS*" /label="recO CDS" gene complement(2207875..2208642) /gene="recO" /locus_tag="BSU_25280" /old_locus_tag="BSU25280" /label="recO gene" CDS complement(2208679..2208822) /gene="yqzL" /locus_tag="BSU_25289" /old_locus_tag="BSU25289" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097761.1" /db_xref="EnsemblGenomes-Gn:BSU25289" /db_xref="EnsemblGenomes-Tr:CAX52661" /db_xref="InterPro:IPR025617" /db_xref="UniProtKB/Swiss-Prot:C0H452" /translation="MLNFTWNVFSQTGNVDTYLLFKELEKENMERPEELEDELARFDY PIL*" /label="yqzL CDS" gene complement(2208679..2208822) /gene="yqzL" /locus_tag="BSU_25289" /old_locus_tag="BSU25289" /label="yqzL gene" S_feature complement(2208823..2208969) /Source="Nicolas_S_feature" /locus_tag="new_2609894_2610040_c" /HighExp="Lbstat, T1.30H, T2.0H, M9-stat, S2, T3.0H, S5, M0t90, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="0.999, 0.998, 1" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S957" CDS complement(2208970..2209875) /gene="era" /locus_tag="BSU_25290" /old_locus_tag="BSU25290" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12399511, 12427945, 12682299, 21646538, 22720735, 27834201, 28132488" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399511, 12427945, 12682299, 21646538, 22720735, 27834201, 28132488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maturation of 16S RNA and assembly of 30S ribosomal subunit GTPase" /protein_id="NP_390407.1" /db_xref="EnsemblGenomes-Gn:BSU25290" /db_xref="EnsemblGenomes-Tr:CAB14458" /db_xref="GOA:P42182" /db_xref="InterPro:IPR004044" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR005662" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030388" /db_xref="SubtiList:BG11188" /db_xref="UniProtKB/Swiss-Prot:P42182" /translation="MTNESFKSGFVSIIGRPNVGKSTFLNRVIGQKIAIMSDKPQTTR NKVQGVLTTGTSQTIFIDTPGIHKPKHKLGDFMMKVAQNTLKEVDLILFMINAEEGYG KGDEFIIEKLQTMSTPVFLIVNKIDKIHPDQLLLLIDEYRKRYPFKEIVPISALEGNN IETLLAQIEAYLPEGPQFYPSDQVTDHPERFIISELIREKVLHLTREEIPHSIAVAIE SIKGQDNGSVHVAATIVVERDSQKGIVIGKKGSLLKEVGKRARADIEALLGSRVYLEL WVKVQKDWRNKMSQLRDFGFKEDEY*" /label="era CDS" gene complement(2208970..2209875) /gene="era" /locus_tag="BSU_25290" /old_locus_tag="BSU25290" /label="era gene" CDS complement(2209856..2210266) /gene="cdd" /locus_tag="BSU_25300" /old_locus_tag="BSU25300" /EC_number="3.5.4.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2526291, 8157589, 10217788, 11851403, 22720735, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2526291, 8157589, 10217788, 11851403, 22720735, 25890046; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytidine/deoxycytidine deaminase" /protein_id="NP_390408.1" /db_xref="EnsemblGenomes-Gn:BSU25300" /db_xref="EnsemblGenomes-Tr:CAB14459" /db_xref="GOA:P19079" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR006262" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="PDB:1JTK" /db_xref="PDB:1UWZ" /db_xref="PDB:1UX0" /db_xref="PDB:1UX1" /db_xref="SubtiList:BG10477" /db_xref="UniProtKB/Swiss-Prot:P19079" /translation="MNRQELITEALKARDMAYAPYSKFQVGAALLTKDGKVYRGCNIE NAAYSMCNCAERTALFKAVSEGDTEFQMLAVAADTPGPVSPCGACRQVISELCTKDVI VVLTNLQGQIKEMTVEELLPGAFSSEDLHDERKL*" /label="cdd CDS" gene complement(2209856..2210266) /gene="cdd" /locus_tag="BSU_25300" /old_locus_tag="BSU25300" /label="cdd gene" promotor_-10 complement(2210304..2210323) /Source="Nicolas_upshift_promotors" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2210315) /Source="Nicolas_upshifts" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="upshifts" S_feature complement(2210317..2210384) /Source="Nicolas_S_feature" /locus_tag="new_2611388_2611455_c" /HighExp="Oxctl, H2O2, G180, G150, GM 120, S1, G135, Diami, LBGtran, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.998, 1" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S958" promotor_-35 complement(2210338..2210341) /Source="Nicolas_upshift_promotors" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2210385..2210756) /gene="unpK" /locus_tag="BSU_25310" /old_locus_tag="BSU25310" /EC_number="2.7.1.66" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12923107, 17535816, 19935659, 28872301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenol kinase" /protein_id="NP_390409.2" /db_xref="EnsemblGenomes-Gn:BSU25310" /db_xref="EnsemblGenomes-Tr:CAB14460" /db_xref="GOA:P19638" /db_xref="InterPro:IPR000829" /db_xref="InterPro:IPR033717" /db_xref="InterPro:IPR036945" /db_xref="SubtiList:BG11040" /db_xref="UniProtKB/Swiss-Prot:P19638" /translation="MDSKDHRNELNRFFKSFVHAGRGIWETARTERNFQFHAAAACAV LICGFLVELSIIEWMIIFLLIGGMFSLELLNTAIEHTVDLITDKHHPLAKAAKDAAAG AVCVFAVISCIIGLLIFLPKL*" /label="unpK CDS" gene complement(2210385..2210756) /gene="unpK" /locus_tag="BSU_25310" /old_locus_tag="BSU25310" /label="unpK gene" CDS complement(2210737..2211210) /gene="rnrY" /locus_tag="BSU_25320" /old_locus_tag="BSU25320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16511207, 16818608, 19181801, 20639334, 20807199, 23273979, 23638028, 24511998, 24901994, 28031281; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease involved in 70S ribosomes quality control" /protein_id="NP_390410.2" /db_xref="EnsemblGenomes-Gn:BSU25320" /db_xref="EnsemblGenomes-Tr:CAB14461" /db_xref="GOA:P46347" /db_xref="InterPro:IPR002036" /db_xref="InterPro:IPR020549" /db_xref="InterPro:IPR023091" /db_xref="SubtiList:BG11656" /db_xref="UniProtKB/Swiss-Prot:P46347" /translation="MSLLIDIVDETGSVSEEMLKEVENLLQFAAEREGVQDQAEVSVT IVSNDDIHQINKEYRGKDAPTDVISFALEEEGEGEIEIVGAEMPPVLGDIIISADRTR EQAEEYNHSFKRELGFLAVHGFLHLLGYDHMTKEEEEEMFTKQKELLDAYGLKRS*" /label="rnrY CDS" gene complement(2210737..2211210) /gene="rnrY" /locus_tag="BSU_25320" /old_locus_tag="BSU25320" /label="rnrY gene" CDS complement(2211211..2213346) /gene="pgpH" /locus_tag="BSU_25330" /old_locus_tag="BSU25330" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16751502, 26240071, 27378384" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751502, 26240071, 27378384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="c-di-AMP-degrading phosphodiesterases" /protein_id="NP_390411.1" /db_xref="EnsemblGenomes-Gn:BSU25330" /db_xref="EnsemblGenomes-Tr:CAB14462" /db_xref="GOA:P46344" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="InterPro:IPR011621" /db_xref="InterPro:IPR011624" /db_xref="SubtiList:BG11655" /db_xref="UniProtKB/Swiss-Prot:P46344" /translation="MLKKKAKTKSSSKKWSSFKNARSMHVLLYLLLAAIMFALLFVHV KPETLDLDLFSVSDKTIYAPATVEDQKATEEKKQAAEDAVEDQYTLKKEYTDNRIDLV SSIFDSISEVKKSSEEGSKSPSEKSMVKSVKDKLTSDVNDSISEDSIKTLLKADSEDF SFVRDTVITAVNTVMSSEIPSDKLSDAKDKVEKELKSNSIPSKYLGAATEIGRFAIIP NYVFDPKATEAKRQEASDNVQQVQIKQGQVLVEENDLIDREVYRKLELTGLLNNSNLF KPISGLLIMIGLFIATLVYYFEKQKQNLKFKNQSILLFSIITTLLLVIMEVVSLFQKM EYNNIGYLVPIAAGAILIKLLMNERIAILGSIILAICGSMMFNQGVTGTFNYVIGIYY LISGISGVLFLGKHNARSKILQTGLFVAFINMVVVLSLLLIQNTALSGLEIGTLMLMG VVSGFASSVLIIGLMPFFETGFGILSTMRLLELSNPNHPLLRKILTETPGTYHHSVMV ANLSEAACEAVGANGLLARVGAYYHDLGKTKRPQYFIENQMNIDNPHDKLSPQLSKNI IISHTTDGANMLRSYKFPKELVDIAEQHHGTSLLKFFYYKAKEKGDQITEEEFRYPGP KPQSKEAAIISVADSVEAAVRSMHNPNPERIEKLVRGIISDKLQDGQFSECDLTFKEL DTIAKTLCATLKGIFHSRIEYPEATKKVK*" /label="pgpH CDS" gene complement(2211211..2213346) /gene="pgpH" /locus_tag="BSU_25330" /old_locus_tag="BSU25330" /label="pgpH gene" promotor_-35 2213190..2213195 /Source="Nicolas_upshift_promotors" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2213210 /Source="Nicolas_upshifts" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2213211..2213229 /Source="Nicolas_upshift_promotors" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2213425..2214384) /gene="phoH" /locus_tag="BSU_25340" /old_locus_tag="BSU25340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12762842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12762842; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="phosphate starvation-induced protein" /protein_id="NP_390412.2" /db_xref="EnsemblGenomes-Gn:BSU25340" /db_xref="EnsemblGenomes-Tr:CAB14476" /db_xref="GOA:P46343" /db_xref="InterPro:IPR003714" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11337" /db_xref="UniProtKB/Swiss-Prot:P46343" /translation="MTEHLLAMNQKLKNPDEALSLFGNQDSFLKLMEKDLNLNIITRG ETIYVSGDDESFQIADRLLGSLLALIRKGIEISERDVIYAIKMAKKNELEYFESMYEE EITKNAKGKSIRVKTMGQREYVAAMKRNDLVFGIGPAGTGKTYLAVVKAVHALKNGHI KKIILTRPAVEAGESLGFLPGDLKEKVDPYLRPLYDALHDVLGADHTERLMERGIIEI APLAYMRGRTLDDAYVILDEAQNTTPAQMKMFLTRLGFGSKMIITGDVSQIDLPKGVK SGLAVAKEMLKGIDGISMIELDQTDVVRHPLVAKIIEAYDKQN*" /label="phoH CDS" gene complement(2213425..2214384) /gene="phoH" /locus_tag="BSU_25340" /old_locus_tag="BSU25340" /label="phoH gene" downshifts complement(2213440) /Source="Nicolas_upshifts" /id="D1313" /incds=0 /nref=1 /ntot=63 /MaxReadThrough="6.04676" /MaxDrop="4.50442" /score="9.12152318" /energy="-13.1" /TU="U1975,U1976,U1977" /idTUdmin="U1978" /TUdmin=1034 /isTUend="FALSE" /label="downshifts" CDS complement(2214381..2215577) /gene="yqfD" /locus_tag="BSU_25350" /old_locus_tag="BSU25350" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14523133, 26735940; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage IV sporulation protein; putative UDP-glucose-4-epimerase" /protein_id="NP_390413.2" /db_xref="EnsemblGenomes-Gn:BSU25350" /db_xref="EnsemblGenomes-Tr:CAB14477" /db_xref="GOA:P54469" /db_xref="InterPro:IPR010690" /db_xref="SubtiList:BG11654" /db_xref="UniProtKB/Swiss-Prot:P54469" /translation="MKNKWLSFFSGKVQLELTGRGIERLLNECTRQGIPVFHVKKKKE AVSLYIQLQDVHAFRRVRSKFKCKARFINRKGFPFLLLKSKLNIGFTIGFAIFFILLF LLSNMVWKIDVTGAKPETEHQMRQHLNEIGVKKGRLQFLMMSPEKIQKSLTNGIDNIT WVGVDLKGTTIHMKVVEKNEPEKEKYVSPRNIVAKKKATITRMFVQKGQPMAAIHDHV EKGQLLVSGLIGSEDHQQEVASKAEIYGETWYRSEVTVPLETLFNVYTGKVRTKHKLS FGSLAIPIWGMTFKKEELKHPKTEQEKHSLHFLGFKLPVSYVKEQTRESEEALRKYTK EEAVQEGIKLGKQDVEDKIGENGEVKSEKVLHQTVENGKVKLIILYQVIEDIVQTTPI VRETEE*" /label="yqfD CDS" gene complement(2214381..2215577) /gene="yqfD" /locus_tag="BSU_25350" /old_locus_tag="BSU25350" /label="yqfD gene" promotor_-10 complement(2214448..2214467) /Source="Nicolas_upshift_promotors" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2214453) /Source="Nicolas_upshifts" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2214481..2214488) /Source="Nicolas_upshift_promotors" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-10 complement(2214528..2214546) /Source="Nicolas_upshift_promotors" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="promotor_-10" upshifts complement(2214540) /Source="Nicolas_upshifts" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="upshifts" promotor_-35 complement(2214561..2214567) /Source="Nicolas_upshift_promotors" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="promotor_-35" upshifts complement(2214755) /Source="Nicolas_upshifts" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="upshifts" promotor_-10 complement(2214769..2214780) /Source="Nicolas_upshift_promotors" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="promotor_-10" promotor_-35 complement(2214795..2214801) /Source="Nicolas_upshift_promotors" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="promotor_-35" CDS complement(2215596..2215877) /gene="yqfC" /locus_tag="BSU_25360" /old_locus_tag="BSU25360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12662922" /codon_start=1 /transl_table=11 /product="conserved sporulation protein of unknown function" /protein_id="NP_390414.1" /db_xref="EnsemblGenomes-Gn:BSU25360" /db_xref="EnsemblGenomes-Tr:CAB14478" /db_xref="InterPro:IPR022476" /db_xref="InterPro:IPR022477" /db_xref="SubtiList:BG11653" /db_xref="UniProtKB/Swiss-Prot:P54468" /translation="MGQRKNRMKAWLTRALEIPPDVMMDLPRITMVGRLHIYIENHRG LLLFSENEVRLMLKQGQCIISGKNFVIKAILPEEILLEGTIDVVRYVES*" /label="yqfC CDS" gene complement(2215596..2215877) /gene="yqfC" /locus_tag="BSU_25360" /old_locus_tag="BSU25360" /label="yqfC gene" CDS complement(2215934..2216353) /gene="yqfB" /locus_tag="BSU_25370" /old_locus_tag="BSU25370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390415.2" /db_xref="EnsemblGenomes-Gn:BSU25370" /db_xref="EnsemblGenomes-Tr:CAB14479" /db_xref="GOA:P54467" /db_xref="InterPro:IPR016788" /db_xref="SubtiList:BG11652" /db_xref="UniProtKB/Swiss-Prot:P54467" /translation="MEDLLTNPLIIAAIIGIISAIFGKKSKEEKQNSQKRKKPQHVQS ASPQKKQSKEDAPAPIPNRMEQARREAEERRRETARNLKGLERDLAAAKQKTVYTKQK MLQVNKDTVVQGIVLGEVFGPPRAKKPHRTMRPARKN*" /label="yqfB CDS" gene complement(2215934..2216353) /gene="yqfB" /locus_tag="BSU_25370" /old_locus_tag="BSU25370" /label="yqfB gene" downshifts complement(2215948) /Source="Nicolas_upshifts" /id="D1314" /incds=0 /nref=232 /ntot=257 /MaxReadThrough="4.55662" /MaxDrop="7.47609" /score="-3.87904232" /energy="-16.8" /TU="U1978" /idTUdmin="U1980" /TUdmin=242 /isTUend="FALSE" /label="downshifts" CDS complement(2216378..2217373) /gene="floA" /locus_tag="BSU_25380" /old_locus_tag="BSU25380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12501411, 22753055" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12501411, 22753055; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="flotillin-like protein involved in membrane lipid rafts" /protein_id="NP_390416.1" /db_xref="EnsemblGenomes-Gn:BSU25380" /db_xref="EnsemblGenomes-Tr:CAB14480" /db_xref="GOA:P54466" /db_xref="InterPro:IPR022853" /db_xref="SubtiList:BG11651" /db_xref="UniProtKB/Swiss-Prot:P54466" /translation="MDPSTLMILAIVAVAIIVLAVFFTFVPVMLWISALAAGVKISIF TLVGMRLRRVIPNRVVNPLIKAHKAGLNVGTNQLESHYLAGGNVDRVVNALIAAQRAN IELTFERCAAIDLAGRDVLEAVQMSVNPKVIETPFIAGVAMDGIEVKAKARITVRANI ERLVGGAGEETIVARVGEGIVSTIGSSDNHKKVLENPDMISQTVLGKGLDSGTAFEIL SIDIADVDIGKNIGAILQTDQAEADKNIAQAKAEERRAMAVAQEQEMRARVEEMRAKV VEAEAEVPLAMAEALREGNIGVMDYMNIKNIDADTEMRDSFGKLTKDPSDEDRKS*" /label="floA CDS" gene complement(2216378..2217373) /gene="floA" /locus_tag="BSU_25380" /old_locus_tag="BSU25380" /label="floA gene" CDS complement(2217395..2218708) /gene="nfeDA" /locus_tag="BSU_25390" /old_locus_tag="BSU25390" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 22753055; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane bound peptidase of unkwnown function" /protein_id="NP_390417.1" /db_xref="EnsemblGenomes-Gn:BSU25390" /db_xref="EnsemblGenomes-Tr:CAB14481" /db_xref="GOA:P54465" /db_xref="InterPro:IPR002810" /db_xref="InterPro:IPR002825" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG11650" /db_xref="UniProtKB/Swiss-Prot:P54465" /translation="MLQIKGFRAALLGIFLLSLLGVQLNAKAEKQTVYVIPVEKNVEQ GLASFLSRSLQDAKDAHADHIILDINTPGGLVKSAIDMADLITESEIPVTAYVNKRAL SAGAYIALQADHIYMAPGGKMGAAAIVDGQGNAADQKAQSLWLAEMEDAAVKNNRDPK YALAMADPDIDAKEVGAPKGDLLTLNADKAIEVGYSEGTADNLSTLVKKLGFEKAQIS YAKESFAEKTARWLTNPVIVPILLTIAFLGLTVELFSPGVGLPGTAGLIALLLFFYGH LAAGLAGYETVLLFIAGVILILLEIFLPGGIIGLLGLGAIIASLFLAAGSFTVMAVSL LIASAVSITAFILLTRVLGKRMKFFKKLILNDSTNTESGYVSNQTRTDLMGKVGITFT PLRPSGTVIIDDERLDVVSEGSFTEKDKKVKVIKVEGSRIVVREI*" /label="nfeDA CDS" gene complement(2217395..2218708) /gene="nfeDA" /locus_tag="BSU_25390" /old_locus_tag="BSU25390" /label="nfeDA gene" promotor_-10 complement(2218744..2218759) /Source="Nicolas_upshift_promotors" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="promotor_-10" upshifts complement(2218761) /Source="Nicolas_upshifts" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="upshifts" promotor_-35 complement(2218772..2218781) /Source="Nicolas_upshift_promotors" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="promotor_-35" CDS complement(2218839..2219285) /gene="yqeY" /locus_tag="BSU_25400" /old_locus_tag="BSU25400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17284460, 22720735, 25149203" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function with tRNA aminoacid amidase domain" /protein_id="NP_390418.1" /db_xref="EnsemblGenomes-Gn:BSU25400" /db_xref="EnsemblGenomes-Tr:CAB14482" /db_xref="GOA:P54464" /db_xref="InterPro:IPR003789" /db_xref="InterPro:IPR019004" /db_xref="InterPro:IPR023168" /db_xref="PDB:1NG6" /db_xref="SubtiList:BG11649" /db_xref="UniProtKB/Swiss-Prot:P54464" /translation="MSLLERLNQDMKLYMKNREKDKLTVVRMVKASLQNEAIKLKKDS LTEDEELTVLSRELKQRKDSLQEFSNANRLDLVDKVQKELDILEVYLPEQLSEEELRT IVNETIAEVGASSKADMGKVMGAIMPKVKGKADGSLINKLVSSQLS*" /label="yqeY CDS" gene complement(2218839..2219285) /gene="yqeY" /locus_tag="BSU_25400" /old_locus_tag="BSU25400" /label="yqeY gene" downshifts complement(2218852) /Source="Nicolas_upshifts" /id="D1315" /incds=0 /nref=248 /ntot=267 /MaxReadThrough="5.1355" /MaxDrop="8.31948" /score="17.2548348" /energy="-10.3" /TU="U1980" /idTUdmin="U1983" /TUdmin=1760 /isTUend="FALSE" /label="downshifts" downshifts complement(2219050) /Source="Nicolas_upshifts" /id="D1316" /incds=1 /nref=1 /ntot=34 /MaxReadThrough="8.99916" /MaxDrop="1.9798" /score="17.2548348" /energy="-10.3" /TU="U1980" /idTUdmin="U1983" /TUdmin=1562 /isTUend="FALSE" /label="downshifts" CDS complement(2219300..2219473) /gene="rpsU" /locus_tag="BSU_25410" /old_locus_tag="BSU25410" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 22720735, 23002217, 25035996" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 22720735, 23002217, 25035996; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S21" /protein_id="NP_390419.1" /db_xref="EnsemblGenomes-Gn:BSU25410" /db_xref="EnsemblGenomes-Tr:CAB14483" /db_xref="GOA:P21478" /db_xref="InterPro:IPR001911" /db_xref="InterPro:IPR018278" /db_xref="SubtiList:BG11648" /db_xref="UniProtKB/Swiss-Prot:P21478" /translation="MSKTVVRKNESLEDALRRFKRSVSKTGTLQEARKREFYEKPSVK RKKKSEAARKRKF*" /label="rpsU CDS" gene complement(2219300..2219473) /gene="rpsU" /locus_tag="BSU_25410" /old_locus_tag="BSU25410" /label="rpsU gene" misc_feature 2219409..2219413 /Source="Nicolas_upshift_promotors" /id="U1979" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.877122877122877" /psig="0.113886113886114" /xcortree=55 /SigmaFactorBS="tttttcataaaattcacgctttcttgcttcttgcaaagtacc tgtctttgatacaCTGCGtttgaagcgacgaagagcatcttcaagcgattcgtttttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2219414 /Source="Nicolas_upshifts" /id="U1979" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.877122877122877" /psig="0.113886113886114" /xcortree=55 /SigmaFactorBS="tttttcataaaattcacgctttcttgcttcttgcaaagtacc tgtctttgatacaCTGCGtttgaagcgacgaagagcatcttcaagcgattcgtttttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2219534..2219553) /Source="Nicolas_upshift_promotors" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2219549) /Source="Nicolas_upshifts" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2219567..2219574) /Source="Nicolas_upshift_promotors" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2219592..2219597 /Source="Nicolas_upshift_promotors" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2219612 /Source="Nicolas_upshifts" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2219613..2219631 /Source="Nicolas_upshift_promotors" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2219646..2220569 /gene="yqeW" /locus_tag="BSU_25420" /old_locus_tag="BSU25420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/anion cotransporter" /protein_id="NP_390420.2" /db_xref="EnsemblGenomes-Gn:BSU25420" /db_xref="EnsemblGenomes-Tr:CAB14484" /db_xref="GOA:P54463" /db_xref="InterPro:IPR003841" /db_xref="InterPro:IPR004633" /db_xref="SubtiList:BG11647" /db_xref="UniProtKB/Swiss-Prot:P54463" /translation="MLILISFTALILFFLAGMNMLRKGLISMAYSKIEERLLLFTDHP LKAFLISIVFTGILQSSSAFMVIVIGFVSAGVLSFKRTIPMILGTNVGSTFTTEFIAI KMDIVIWVLLIGGLLFFLTGRYPLKQLGTSFLGLGIIFFCISGFSHLAGPLTKLKTGA DVLYHVNDSNWSALLIGMVLTAIIHSSSVCIGILMSFMNEGIIGLTQAMSVVLGSNIG TCITAVMAAVSGGYAAKQTAYAHVVFNVLGVALVLPFLTAATGFVEQLSPDPAQKIAH FSLLFNVVTALLFLPLTNLFYRLIHLLIPAK*" /label="yqeW CDS" gene 2219646..2220569 /gene="yqeW" /locus_tag="BSU_25420" /old_locus_tag="BSU25420" /label="yqeW gene" CDS complement(2220606..2221961) /gene="mtaB" /locus_tag="BSU_25430" /old_locus_tag="BSU25430" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6163767, 9023197, 10572129, 15339930, 18252828, 8844851, 20472640, 20584901, 27913733" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6163767, 9023197, 10572129, 15339930, 18252828, 8844851, 20472640, 20584901, 27913733; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA N(6)-threonylcarbamoyladenosine (t(6)A) methylthiotransferase" /protein_id="NP_390421.1" /db_xref="EnsemblGenomes-Gn:BSU25430" /db_xref="EnsemblGenomes-Tr:CAB14485" /db_xref="GOA:P54462" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR005839" /db_xref="InterPro:IPR006467" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013848" /db_xref="InterPro:IPR020612" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR034557" /db_xref="SubtiList:BG11646" /db_xref="UniProtKB/Swiss-Prot:P54462" /translation="MATVAFHTLGCKVNHYETEAIWQLFKEAGYERRDFEQTADVYVI NTCTVTNTGDKKSRQVIRRAIRQNPDGVICVTGCYAQTSPAEIMAIPGVDIVVGTQDR EKMLGYIDQYREERQPINGVSNIMKARVYEELDVPAFTDRTRASLKIQEGCNNFCTFC IIPWARGLLRSRDPEEVIKQAQQLVDAGYKEIVLTGIHTGGYGEDMKDYNFAKLLSEL DTRVEGVKRIRISSIEASQITDEVIEVLDRSDKIVNHLHIPIQSGSNTVLKRMRRKYT MEFFADRLNKLKKALPGLAVTSDVIVGFPGETEEEFMETYNFIKEHKFSELHVFPYSK RTGTPAARMEDQVDENVKNERVHRLIALSDQLAKEYASQYENEVLEIIPEEAFKETEE ENMFVGYTDNYMKVVFKGTEDMIGKIVKVKILKAGYPYNEGQFVRVVEDEITEHMRLS S*" /label="mtaB CDS" gene complement(2220606..2221961) /gene="mtaB" /locus_tag="BSU_25430" /old_locus_tag="BSU25430" /label="mtaB gene" downshifts complement(2220612) /Source="Nicolas_upshifts" /id="D1317" /incds=0 /nref=208 /ntot=260 /MaxReadThrough="1.95578" /MaxDrop="6.05381" /score="30.7201786" /energy="-11.3" /TU="NA" /idTUdmin="U1983" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2221961..2222731) /gene="rsmE" /locus_tag="BSU_25440" /old_locus_tag="BSU25440" /EC_number="2.1.1.193" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9023197, 10383760, 14517985, 16014871, 16431987, 22925577, 24598751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylase of U1498 in 16S rRNA" /protein_id="NP_390422.1" /db_xref="EnsemblGenomes-Gn:BSU25440" /db_xref="EnsemblGenomes-Tr:CAB14486" /db_xref="GOA:P54461" /db_xref="InterPro:IPR006700" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="PDB:1VHK" /db_xref="SubtiList:BG11645" /db_xref="UniProtKB/Swiss-Prot:P54461" /translation="MQRYFIELTKQQIEEAPTFSITGEEVHHIVNVMRMNEGDQIICC SQDGFEAKCELQSVSKDKVSCLVIEWTNENRELPIKVYIASGLPKGDKLEWIIQKGTE LGAHAFIPFQAARSVVKLDDKKAKKKRERWTKIAKEAAEQSYRNEVPRVMDVHSFQQL LQRMQDFDKCVVAYEESSKQGEISAFSAIVSSLPKGSSLLIVFGPEGGLTEAEVERLT EQDGVTCGLGPRILRTETAPLYALSAISYQTELLRGDQ*" /label="rsmE CDS" gene complement(2221961..2222731) /gene="rsmE" /locus_tag="BSU_25440" /old_locus_tag="BSU25440" /label="rsmE gene" CDS complement(2222754..2223689) /gene="prmA" /locus_tag="BSU_25450" /old_locus_tag="BSU25450" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17215866, 18611379; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein L11 methyltransferase" /protein_id="NP_390423.2" /db_xref="EnsemblGenomes-Gn:BSU25450" /db_xref="EnsemblGenomes-Tr:CAB14487" /db_xref="GOA:P54460" /db_xref="InterPro:IPR004498" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11644" /db_xref="UniProtKB/Swiss-Prot:P54460" /translation="MKWSELSIHTTHEAVEPISNILHEAGASGVVIEDPLDLIKEREN VYGEIYQLDPNDYPDEGVIVKAYLPVNSFLGETVDGIKETINNLLLYNIDLGRNHITI SEVNEEEWATAWKKYYHPVKISEKFTIVPTWEEYTPVHTDELIIEMDPGMAFGTGTHP TTVLCIQALERFVQKGDKVIDVGTGSGILSIAAAMLEAESVHAYDLDPVAVESARLNL KLNKVSDIAQVKQNNLLDGIEGEHDVIVANILAEVILRFTSQAYSLLKEGGHFITSGI IGHKKQEVKEALEQAGFTIVEILSMEDWVSIIAKK*" /label="prmA CDS" gene complement(2222754..2223689) /gene="prmA" /locus_tag="BSU_25450" /old_locus_tag="BSU25450" /label="prmA gene" CDS complement(2223714..2224841) /gene="dnaJ" /locus_tag="BSU_25460" /old_locus_tag="BSU25460" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10383760, 10658654, 16385044, 16952052" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10383760, 10658654, 16385044, 16952052; Product type f: factor" /codon_start=1 /transl_table=11 /product="co-factor of molecular chaperone" /protein_id="NP_390424.2" /db_xref="EnsemblGenomes-Gn:BSU25460" /db_xref="EnsemblGenomes-Tr:CAB14488" /db_xref="GOA:P17631" /db_xref="InterPro:IPR001305" /db_xref="InterPro:IPR001623" /db_xref="InterPro:IPR002939" /db_xref="InterPro:IPR008971" /db_xref="InterPro:IPR012724" /db_xref="InterPro:IPR018253" /db_xref="InterPro:IPR036410" /db_xref="InterPro:IPR036869" /db_xref="SubtiList:BG10665" /db_xref="UniProtKB/Swiss-Prot:P17631" /translation="MSKRDYYEVLGVSKSASKDEIKKAYRKLSKKYHPDINKEAGSDE KFKEVKEAYETLSDDQKRAHYDQFGHTDPNQGFGGGGFGGGDFGGFGFDDIFSSIFGG GTRRRDPNAPRQGADLQYTMTLSFEDAAFGKETTIEIPREETCETCKGSGAKPGTNPE TCSHCGGSGQLNVEQNTPFGKVVNRRVCHHCEGTGKIIKNKCADCGGKGKIKKRKKIN VTIPAGVDDGQQLRLSGQGEPGINGGPAGDLFVVFHVRAHEFFERDGDDIYCEMPLTF AQAALGDEVEVPTLHGKVKLKIPAGTQTGTKFRLRGKGVQNVRGYGQGDQHIVVRVVT PTNLTDKQKDIIREFAEVSGNLPDEQEMSFFDKVKRAFKGD*" /label="dnaJ CDS" gene complement(2223714..2224841) /gene="dnaJ" /locus_tag="BSU_25460" /old_locus_tag="BSU25460" /label="dnaJ gene" misc_feature 2224758..2224761 /Source="Nicolas_upshift_promotors" /id="U1982" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.014985014985015" /xcortree=39 /SigmaFactorBS="tttcatctgatccggcttctttgttaatatcaggatgatatt tttttgaCAGCttccgataagcttttttaatttcatcctttgaagcgctcttacttac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2224769 /Source="Nicolas_upshifts" /id="U1982" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.014985014985015" /xcortree=39 /SigmaFactorBS="tttcatctgatccggcttctttgttaatatcaggatgatatt tttttgaCAGCttccgataagcttttttaatttcatcctttgaagcgctcttacttac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2224842..2225019) /Source="Nicolas_S_feature" /locus_tag="new_2625913_2626090_c" /HighExp="Heat, dia15, H2O2, Diami, G135, G150, G180, LPhT, Etha, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.357489" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF" /TUlongPSig="0.978" /label="S959" misc_RNA 2224881..2224971 /gene="surC" /locus_tag="BSU_misc_RNA_79" /product="sporulation-related small untranslated RNA" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" /label="surC RNA" gene 2224881..2224971 /gene="surC" /locus_tag="BSU_misc_RNA_79" /label="surC gene" CDS complement(2225041..2226876) /gene="dnaK" /locus_tag="BSU_25470" /old_locus_tag="BSU25470" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10074100, 12224648, 12799007, 17407764, 22938038, 25355936, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10074100, 12224648, 12799007, 17407764, 22938038, 25355936, 27148221; Product type f: factor" /codon_start=1 /transl_table=11 /product="molecular chaperone, ATP-dependent" /protein_id="NP_390425.1" /db_xref="EnsemblGenomes-Gn:BSU25470" /db_xref="EnsemblGenomes-Tr:CAB14489" /db_xref="GOA:P17820" /db_xref="InterPro:IPR012725" /db_xref="InterPro:IPR013126" /db_xref="InterPro:IPR018181" /db_xref="InterPro:IPR029047" /db_xref="InterPro:IPR029048" /db_xref="PDB:2FZO" /db_xref="SubtiList:BG10664" /db_xref="UniProtKB/Swiss-Prot:P17820" /translation="MSKVIGIDLGTTNSCVAVLEGGEPKVIANAEGNRTTPSVVAFKN GERQVGEVAKRQSITNPNTIMSIKRHMGTDYKVEIEGKDYTPQEVSAIILQHLKSYAE SYLGETVSKAVITVPAYFNDAERQATKDAGKIAGLEVERIINEPTAAALAYGLDKTDE DQTILVYDLGGGTFDVSILELGDGVFEVRSTAGDNRLGGDDFDQVIIDHLVSEFKKEN GIDLSKDKMALQRLKDAAEKAKKDLSGVSSTQISLPFITAGEAGPLHLELTLTRAKFE ELSSHLVERTMGPVRQALQDAGLSASEIDKVILVGGSTRIPAVQEAIKKETGKEAHKG VNPDEVVALGAAIQGGVITGDVKDVVLLDVTPLSLGIETMGGVFTKLIDRNTTIPTSK SQVFSTAADNQTAVDIHVLQGERPMSADNKTLGRFQLTDIPPAPRGVPQIEVSFDIDK NGIVNVRAKDLGTGKEQNITIKSSSGLSDEEIERMVKEAEENADADAKKKEEIEVRNE ADQLVFQTEKTLKDLEGKVDEEQVKKANDAKDALKAAIEKNEFEEIKAKKDELQTIVQ ELSMKLYEEAAKAQQAQGGANAEGKADDNVVDAEYEEVNDDQNKK*" /label="dnaK CDS" gene complement(2225041..2226876) /gene="dnaK" /locus_tag="BSU_25470" /old_locus_tag="BSU25470" /label="dnaK gene" downshifts complement(2225064) /Source="Nicolas_upshifts" /id="D1318" /incds=0 /nref=130 /ntot=247 /MaxReadThrough="8.0737" /MaxDrop="4.023" /score="21.9400858" /energy="-13.4" /TU="U1983,U1985" /idTUdmin="U1984" /TUdmin=3565 /isTUend="FALSE" /label="downshifts" CDS complement(2226900..2227463) /gene="grpE" /locus_tag="BSU_25480" /old_locus_tag="BSU25480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9303302, 10383760, 12682299, 17289679, 21546913, 22720735, 22938038, 26913285" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9303302, 10383760, 12682299, 17289679, 21546913, 22720735, 22938038, 26913285; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nucleotide exchange factor for DnaK activity" /protein_id="NP_390426.1" /db_xref="EnsemblGenomes-Gn:BSU25480" /db_xref="EnsemblGenomes-Tr:CAB14490" /db_xref="GOA:P15874" /db_xref="InterPro:IPR000740" /db_xref="InterPro:IPR009012" /db_xref="InterPro:IPR013805" /db_xref="PDB:2G61" /db_xref="SubtiList:BG10663" /db_xref="UniProtKB/Swiss-Prot:P15874" /translation="MSEEKQTVEQNETEEQEIIEEQAAADEQQEETNESELLQNQINE LQGLLEEKENKLLRVQADFENYKRRSRLEMEASQKYRSQNIVTDLLPALDSFERALQV EADNEQTKSLLQGMEMVHRQLVEALKKEGVEAIEAVGQEFDPNLHQAVMQAEDENYGS NIVVEEMQKGYKLKDRVIRPSMVKVNQ*" /label="grpE CDS" gene complement(2226900..2227463) /gene="grpE" /locus_tag="BSU_25480" /old_locus_tag="BSU25480" /label="grpE gene" S_feature complement(2227464..2227534) /Source="Nicolas_S_feature" /locus_tag="new_2628535_2628605_c" /HighExp="LPhT, dia15, Heat, Etha, Diami, dia5, H2O2, T-0.40H, T0.30H, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF" /TUlongPSig="0.978" /label="S960" CDS complement(2227535..2228566) /gene="hrcA" /locus_tag="BSU_25490" /old_locus_tag="BSU25490" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10555317, 12082092, 15109714, 16872404, 16585746, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10555317, 12082092, 15109714, 16872404, 16585746, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of heat-shock genes" /protein_id="NP_390427.1" /db_xref="EnsemblGenomes-Gn:BSU25490" /db_xref="EnsemblGenomes-Tr:CAB14491" /db_xref="GOA:P25499" /db_xref="InterPro:IPR002571" /db_xref="InterPro:IPR021153" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10662" /db_xref="UniProtKB/Swiss-Prot:P25499" /translation="MLTNRQLLILQVIINDFIKSAQPVGSRTLSKKDEITFSSATIRN EMADLEELGFIEKTHSSSGRVPSEKGYRYYVDHLLSPVKLTKSDLDQIHSIFKEKIFE LEKTVQKSAQILSDLTNYTSIVLGPKLSENYLKQIQIIPIQPDMAVAILVTNTGHVEN KTINFPTKMDLSDIEKLVNILNDRLSGVPMDELNERIFKEVVMYLRQHIKNYDNILDA LRSTFHSTNHVEKLFFGGKINMLNQPEFHDITRVRSLLSLIEKEQDVLKLVQSPHTGI SIKIGKENDYEEMENCSLITASYSVDQKQIGSIAIIGPTRMNYSRVVSLLQHVTSDLS KALTSLYDE*" /label="hrcA CDS" gene complement(2227535..2228566) /gene="hrcA" /locus_tag="BSU_25490" /old_locus_tag="BSU25490" /label="hrcA gene" promotor_-10 complement(2228607..2228626) /Source="Nicolas_upshift_promotors" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2228620) /Source="Nicolas_upshifts" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2228641..2228648) /Source="Nicolas_upshift_promotors" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2228647..2229786) /gene="hemN" /locus_tag="BSU_25500" /old_locus_tag="BSU25500" /EC_number="1.3.98.3" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8757728, 9371469, 10498703, 12196143, 19944166" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8757728, 9371469, 10498703, 12196143, 19944166; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coproporphyrinogen III oxidase" /protein_id="NP_390428.2" /db_xref="EnsemblGenomes-Gn:BSU25500" /db_xref="EnsemblGenomes-Tr:CAB14492" /db_xref="GOA:P54304" /db_xref="InterPro:IPR004559" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010723" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR034505" /db_xref="SubtiList:BG11395" /db_xref="UniProtKB/Swiss-Prot:P54304" /translation="MKSAYIHIPFCEHICHYCDFNKYFIQSQPVDEYLNALEQEMINT IAKTGQPDLKTIFIGGGTPTSLSEEQLKKLMDMINRVLKPSSDLSEFAVEANPDDLSA EKLKILKEAGVNRLSFGVQTFEDDLLEKIGRVHKQKDVFTSFERAREIGFENISLDLM FGLPGQTLKHLEHSINTALSLDAEHYSVYSLIVEPKTVFYNLMQKGRLHLPPQEQEAE MYEIVMSKMEAHGIHQYEISNFAKAGMESKHNLTYWSNEQYFGFGAGAHGYIGGTRTV NVGPVKHYIDLIAEKGFPYRDTHEVTTEEQIEEEMFLGLRKTAGVSKKRFAEKYGRSL DGLFPSVLKDLAEKGLIHNSESAVYLTHQGKLLGNEVFGAFLGEL*" /label="hemN CDS" gene complement(2228647..2229786) /gene="hemN" /locus_tag="BSU_25500" /old_locus_tag="BSU25500" /label="hemN gene" promotor_-10 complement(2229659..2229670) /Source="Nicolas_upshift_promotors" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="promotor_-10" upshifts complement(2229663) /Source="Nicolas_upshifts" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="upshifts" promotor_-35 complement(2229684..2229690) /Source="Nicolas_upshift_promotors" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="promotor_-35" CDS complement(2229839..2231677) /gene="lepA" /locus_tag="BSU_25510" /old_locus_tag="BSU25510" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12511492, 17110332, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal elongation factor, GTPase" /protein_id="NP_390429.1" /db_xref="EnsemblGenomes-Gn:BSU25510" /db_xref="EnsemblGenomes-Tr:CAB14493" /db_xref="GOA:P37949" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006297" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR013842" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035654" /db_xref="SubtiList:BG10441" /db_xref="UniProtKB/Swiss-Prot:P37949" /translation="MTDKEKRLERQSRIRNFSIIAHIDHGKSTLADRILEKTSAITQR EMKEQLLDSMDLERERGITIKLNSVQLKYKAKDGEEYIFHLIDTPGHVDFTYEVSRSL AACEGAILVVDAAQGIEAQTLANVYLALDNDLEILPVINKIDLPSAEPERVRQEVEDV IGLDASEAVLASAKAGIGIEEILEQIVEKVPAPTGDPEAPLKALIFDSLYDAYRGVVA YIRVVEGTVKPGQKIKMMATGKEFEVTEVGVFTPKATPTNELTVGDVGFLTASIKNVG DTRVGDTITSAANPAEEALPGYRKLNPMVYCGLYPIDTAKYNDLREALEKLELNDSSL QYEAETSQALGFGFRCGFLGMLHMEIIQERIEREFNIDLITTAPSVIYDVYMTDGEKV VVDNPSNMPDPQKIERVEEPYVKATMMVPNDYVGAVMELCQGKRGNFIDMQYLDANRV SIIYDMPLAEIVYEFFDQLKSSTKGYASFDYELIGYKPSKLVKMDIMLNGEKIDALSF IVHRDYAYERGKVIVEKLKELIPRQQFEVPVQAAIGQKIVARSTIKAMRKNVLAKCYG GDISRKRKLLEKQKEGKRRMKQVGSVEVPQEAFMAVLKMDDSPKKQ*" /label="lepA CDS" gene complement(2229839..2231677) /gene="lepA" /locus_tag="BSU_25510" /old_locus_tag="BSU25510" /label="lepA gene" downshifts complement(2229861) /Source="Nicolas_upshifts" /id="D1319" /incds=0 /nref=15 /ntot=213 /MaxReadThrough="5.2925" /MaxDrop="3.979" /score="5.45344919" /energy="-14" /TU="U1985" /idTUdmin="U1984" /TUdmin="-1232" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2231712..2231731) /Source="Nicolas_upshift_promotors" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2231729) /Source="Nicolas_upshifts" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2231747..2231751) /Source="Nicolas_upshift_promotors" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2231811..2232149) /gene="yqxA" /locus_tag="BSU_25520" /old_locus_tag="BSU25520" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390430.1" /db_xref="EnsemblGenomes-Gn:BSU25520" /db_xref="EnsemblGenomes-Tr:CAB14494" /db_xref="InterPro:IPR020534" /db_xref="SubtiList:BG10440" /db_xref="UniProtKB/Swiss-Prot:P38425" /translation="MIAYFGKCLLLVTIMFLGVLFGMQQANHGMLSMKGYHDPSLKGA FTLTDGKDNEKEASILGETVTAKDLVEKQKELEKVETFNMFSKAGKALSDTVTNTAQS MYEWIRDMNQ*" /label="yqxA CDS" gene complement(2231811..2232149) /gene="yqxA" /locus_tag="BSU_25520" /old_locus_tag="BSU25520" /label="yqxA gene" downshifts complement(2231817) /Source="Nicolas_upshifts" /id="D1320" /incds=0 /nref=11 /ntot=43 /MaxReadThrough="2.553" /MaxDrop="3.8126" /score="5.45344919" /energy="-14" /TU="NA" /idTUdmin="U1986" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(2232166..2233371) /gene="spoIIP" /locus_tag="BSU_25530" /old_locus_tag="BSU25530" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17376078, 23834622" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17376078, 23834622; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore autolysin (stage II sporulation)" /protein_id="NP_390431.1" /db_xref="EnsemblGenomes-Gn:BSU25530" /db_xref="EnsemblGenomes-Tr:CAB14495" /db_xref="GOA:P37968" /db_xref="InterPro:IPR010897" /db_xref="SubtiList:BG10439" /db_xref="UniProtKB/Swiss-Prot:P37968" /translation="MRNKRRNRQIVVAVNGGKAVKAIFLFIVSLIVIFVLSGVLTSLR PELRPSSDSFYGIAEELPGDVFAHLLQMENHYFASDLSQTDSSFHLSRLSLKLATSIN LEDPRSFLGRELPGFAQFDTEILLAGQGTDYTNMPAESPPPSKVMEEEREANLAEIEK QQTQSDNAQKDPPKQTTGDKKVVFIYHTHNTESYLPLLKGETDPDMARHSKANVTLVG DMFGQALESQGIGATVNKTDIQSKLNKKGLNYARSYDESRPVVKDALASNKNLQYIID IHRDSRRKKDTTATIKGKSYARVAFVVGKKSKNFEENYKIASELHKLMEKKYPGLSTG VFSKGSPGDNGVYNQDLTDRALLLEFGGVDNNLEELQRAANAAADVFSEMYWDAEKVN AASGETKKQ*" /label="spoIIP CDS" gene complement(2232166..2233371) /gene="spoIIP" /locus_tag="BSU_25530" /old_locus_tag="BSU25530" /label="spoIIP gene" promotor_-10 complement(2233391..2233409) /Source="Nicolas_upshift_promotors" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2233403) /Source="Nicolas_upshifts" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2233425..2233430) /Source="Nicolas_upshift_promotors" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2233434..2234540) /gene="gpr" /locus_tag="BSU_25540" /old_locus_tag="BSU25540" /EC_number="3.4.24.78" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10666631, 10986255, 12807468, 23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10666631, 10986255, 12807468, 23927687; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protease" /protein_id="NP_390432.1" /db_xref="EnsemblGenomes-Gn:BSU25540" /db_xref="EnsemblGenomes-Tr:CAB14496" /db_xref="GOA:P22322" /db_xref="InterPro:IPR005080" /db_xref="InterPro:IPR023430" /db_xref="SubtiList:BG10438" /db_xref="UniProtKB/Swiss-Prot:P22322" /translation="MKKSELDVNQYLIRTDLAVETKEAMANQQAVPTKEIKGFIEKER DHGGIKIRTVDVTKEGAELSGKKEGRYLTLEAQGIRENDSEMQEKVSAVFAEEFSAFL ENLNISKDASCLIVGLGNWNVTPDALGPMAVENLLVTRHLFKLQPENVQEGYRPVSAF APGVMGITGIETSDIIKGVIEQSKPDFVIAIDALAARAVERVNTTIQISDTGIHPGSG VGNKRKDLSKDTLGVPVIAIGVPTVVDAVTIASDTVDYILKHFGREMKDNRPSRSLVP AGMTFGKKKVLTEDDLPDQKQRQSFLGIVGTLQEDEKRQLIHEVLSPLGHNLMVTPKE VDSFIDDMANVLANGLNTALHEKVSQENKGSYNH*" /label="gpr CDS" gene complement(2233434..2234540) /gene="gpr" /locus_tag="BSU_25540" /old_locus_tag="BSU25540" /label="gpr gene" promotor_-10 complement(2234568..2234579) /Source="Nicolas_upshift_promotors" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2234575) /Source="Nicolas_upshifts" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2234594..2234600) /Source="Nicolas_upshift_promotors" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2234639..2234642 /Source="Nicolas_upshift_promotors" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2234655 /Source="Nicolas_upshifts" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2234658..2234677 /Source="Nicolas_upshift_promotors" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2234669..2234743 /Source="Nicolas_S_feature" /locus_tag="new_2635740_2635814" /HighExp="HiTm, LPhT, UNK1, HiOs, dia5, aero, MG 15, SMM, Lbtran, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S961" CDS 2234744..2235010 /gene="rpsT" /locus_tag="BSU_25550" /old_locus_tag="BSU25550" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16629673, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16629673, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S20 (BS20)" /protein_id="NP_390433.2" /db_xref="EnsemblGenomes-Gn:BSU25550" /db_xref="EnsemblGenomes-Tr:CAB14497" /db_xref="GOA:P21477" /db_xref="InterPro:IPR002583" /db_xref="InterPro:IPR036510" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11643" /db_xref="UniProtKB/Swiss-Prot:P21477" /translation="MPNIKSAIKRTKTNNERRVHNATIKSAMRTAIKQVEASVANNEA DKAKTALTEAAKRIDKAVKTGLVHKNTAARYKSRLAKKVNGLSA*" /label="rpsT CDS" gene 2234744..2235010 /gene="rpsT" /locus_tag="BSU_25550" /old_locus_tag="BSU25550" /label="rpsT gene" downshifts 2234999 /Source="Nicolas_upshifts" /id="D1321" /incds=0 /nref=244 /ntot=274 /MaxReadThrough="2.22204" /MaxDrop="8.54705" /score="33.3621187" /energy="-12.3" /TU="NA" /idTUdmin="U1988" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2235025..2236068) /gene="holA" /locus_tag="BSU_25560" /old_locus_tag="BSU25560" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9434186, 11432857, 12060778, 12682299, 22333191, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9434186, 11432857, 12060778, 12682299, 22333191, 23525462; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase clamp loader delta subunit" /protein_id="NP_390434.1" /db_xref="EnsemblGenomes-Gn:BSU25560" /db_xref="EnsemblGenomes-Tr:CAB14498" /db_xref="GOA:P54459" /db_xref="InterPro:IPR005790" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR010372" /db_xref="InterPro:IPR027417" /db_xref="PDB:3ZH9" /db_xref="SubtiList:BG11642" /db_xref="UniProtKB/Swiss-Prot:P54459" /translation="MVFDVWKSLKKGEVHPVYCLYGKETYLLQETVSRIRQTVVDQET KDFNLSVFDLEEDPLDQAIADAETFPFMGERRLVIVKNPYFLTGEKKKEKIEHNVSAL ESYIQSPAPYTVFVLLAPYEKLDERKKLTKALKKHAFMMEAKELNAKETTDFTVNLAK TEQKTIGTEAAEHLVLLVNGHLSSIFQEIQKLCTFIGDREEITLDDVKMLVARSLEQN IFELINKIVNRKRTESLQIFYDLLKQNEEPIKIMALISNQFRLILQTKYFAEQGYGQK QIASNLKVHPFRVKLAMDQARLFSEEELRLIIEQLAVMDYEMKTGKKDKQLLLELFLL QLLKRNEKNDPHY*" /label="holA CDS" gene complement(2235025..2236068) /gene="holA" /locus_tag="BSU_25560" /old_locus_tag="BSU25560" /label="holA gene" downshifts complement(2235070) /Source="Nicolas_upshifts" /id="D1322" /incds=0 /nref=14 /ntot=198 /MaxReadThrough="1.76478" /MaxDrop="4.34213" /score="-1.12561483" /energy="-8.1" /TU="NA" /idTUdmin="U1989" /TUdmin=5 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2236097..2236116) /Source="Nicolas_upshift_promotors" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2236108..2236257) /locus_tag="BSU_25565" /old_locus_tag="BSU25565" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513978.1" /translation="MKNLEAKVTFSVLVIIAFLQAVPGACEQAFNINGEAAVRLPLYY FANSI*" /label="hypothetical protein CDS" gene complement(2236108..2236257) /locus_tag="BSU_25565" /old_locus_tag="BSU25565" /label="gene" upshifts complement(2236109) /Source="Nicolas_upshifts" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2236130..2236134) /Source="Nicolas_upshift_promotors" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2236132..2236471) /Source="Nicolas_S_feature" /locus_tag="new_2637203_2637542_c" /HighExp="S8, S6, S7, BT, S5, C30, Pyr, G/S, B36, GM 150" /AntisenseName="yqzM" /AntisenseCor="-2.0369593011890001E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S962" downshifts complement(2236175) /Source="Nicolas_upshifts" /id="D1323" /incds=0 /nref=4 /ntot=37 /MaxReadThrough="5.04584" /MaxDrop="3.298" /score="-1.12561483" /energy="-8.1" /TU="U1991,U1995" /idTUdmin="U1992" /TUdmin=748 /isTUend="FALSE" /label="downshifts" promotor_-35 2236244..2236250 /Source="Nicolas_upshift_promotors" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2236264..2236283 /Source="Nicolas_upshift_promotors" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2236265 /Source="Nicolas_upshifts" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="upshifts" CDS 2236298..2236432 /gene="yqzM" /locus_tag="BSU_25569" /old_locus_tag="BSU25569" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097762.1" /db_xref="EnsemblGenomes-Gn:BSU25569" /db_xref="EnsemblGenomes-Tr:CAX52662" /db_xref="GOA:C0H453" /db_xref="InterPro:IPR025416" /db_xref="UniProtKB/Swiss-Prot:C0H453" /translation="MNDFEKNVQSKRNDAVDSAVGFVVSFGFFAFLFVMATVIHLVGS *" /label="yqzM CDS" gene 2236298..2236432 /gene="yqzM" /locus_tag="BSU_25569" /old_locus_tag="BSU25569" /label="yqzM gene" downshifts 2236426 /Source="Nicolas_upshifts" /id="D1324" /incds=0 /nref=156 /ntot=250 /MaxReadThrough="3.51266" /MaxDrop="6.2258" /score="20.1810918" /energy="-12.1" /TU="U1990" /idTUdmin="U1990" /TUdmin="-465" /isTUend="FALSE" /label="downshifts" CDS complement(2236472..2238802) /gene="comEC" /locus_tag="BSU_25570" /old_locus_tag="BSU25570" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12123453, 15661011, 16751195, 17630974, 21397556, 27318187" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123453, 15661011, 16751195, 17630974, 21397556, 27318187; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="DNA channel for uptake in competent cells" /protein_id="NP_390435.1" /db_xref="EnsemblGenomes-Gn:BSU25570" /db_xref="EnsemblGenomes-Tr:CAB14499" /db_xref="GOA:P39695" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR004477" /db_xref="InterPro:IPR004797" /db_xref="InterPro:IPR025405" /db_xref="InterPro:IPR035681" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG10482" /db_xref="UniProtKB/Swiss-Prot:P39695" /translation="MRNSRLLLPMAAASATAGITAAAYFPAIFLFILFLLIILIKTRH AFLIIVCFFSFILFFVLYAVTDSQNVSSYRQGTYQFKAVIDTIPKIDGDRMSMMVETP DKEKWAAAYRIQSAGEKEQLLYIEPGMSCELTGTLEEPNHATVPGAFDYNEYLYRQHI HWNYSVTSIQNCSEPENFKYKVLSLRKHIISFTNSLLPPDSTGIVQALTVGDRFYVED EVLTAYQKLGVVHLLAISGLHVGILTAGLFYIMIRLGITREKASILLLLFLPLYVMLT GAAPSVLRAALMSGVYLAGSLVKWRVRSATAICLSYIVLLLFNPYHLFEAGFQLSFAV SFSLILSSSIFQQVKTSLGQLTIVSLIAQLGSLPILLYHFHQFSIISVPMNMLMVPFY TFCILPGAVAGVLLLSLSASFGRLFFSWFDLLISWINRLITNIADVDVFTIMIAHPAP VLLFLFTVTIILLLMAIEKRSLSQLMVTGGICCTVMFLLFIYPCLSSEGEVDMIDIGQ GDSMFVGAPHQRGRVLIDTGGTLSYSSEPWREKQHPFSLGEKVLIPFLTAKGIKQLDA LILTHADQDHIGEAEILLKHHKVKRLVIPKGFVSEPKDEKVLQAAREEGVAIEEVKRG DVLQIKDLQFHVLSPEAPDPASKNNSSLVLWMETGGMSWILTGDLEKEGEQEVMNVFP NIKADVLKVGHHGSKGSTGEEFIQQLQPKTAIISAGKNNRYHHPHQKVLQLLQRHSIR VLRTDQNGTIQYRYKNRVGTFSVYPPYDTSDITETN*" /label="comEC CDS" gene complement(2236472..2238802) /gene="comEC" /locus_tag="BSU_25570" /old_locus_tag="BSU25570" /label="comEC gene" promotor_-10 complement(2236489..2236508) /Source="Nicolas_upshift_promotors" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2236505) /Source="Nicolas_upshifts" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2236522..2236531) /Source="Nicolas_upshift_promotors" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2238806..2239375) /gene="comEB" /locus_tag="BSU_25580" /old_locus_tag="BSU25580" /EC_number="3.5.4.12" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 7768800, 26416910; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="dCMP deaminase associated to DNA transport (competence)" /protein_id="NP_390436.1" /db_xref="EnsemblGenomes-Gn:BSU25580" /db_xref="EnsemblGenomes-Tr:CAB14500" /db_xref="GOA:P32393" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR013404" /db_xref="InterPro:IPR015517" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR016473" /db_xref="InterPro:IPR035105" /db_xref="SubtiList:BG10481" /db_xref="UniProtKB/Swiss-Prot:P32393" /translation="MERISWNQYFMAQSHLLALRSTCPRLSVGATIVRDKRMIAGGYN GSIAGGVHCADEGCLMIDDHCARTIHAEMNAILQCSKFGVPTDGAEIYVTHYPCIQCC KSIIQAGIKTVYYAEDYKTHPYAQELFEQAGVTVEQVELDEMIVDLKNREKLSFVAGL IGKLADAGLAEEELKKIHEQANTLFTSYV*" /label="comEB CDS" gene complement(2238806..2239375) /gene="comEB" /locus_tag="BSU_25580" /old_locus_tag="BSU25580" /label="comEB gene" promotor_-10 complement(2239402..2239421) /Source="Nicolas_upshift_promotors" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2239412) /Source="Nicolas_upshifts" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2239436..2239443) /Source="Nicolas_upshift_promotors" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2239442..2240059) /gene="comEA" /locus_tag="BSU_25590" /old_locus_tag="BSU25590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16751195, 21278288, 22398145, 25727469" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751195, 21278288, 22398145, 25727469; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="membrane bound high-affinity DNA-binding receptor" /protein_id="NP_390437.1" /db_xref="EnsemblGenomes-Gn:BSU25590" /db_xref="EnsemblGenomes-Tr:CAB14501" /db_xref="GOA:P39694" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004509" /db_xref="InterPro:IPR004787" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR019554" /db_xref="SubtiList:BG10480" /db_xref="UniProtKB/Swiss-Prot:P39694" /translation="MNWLNQHKKAIILAASAAVFTAIMIFLATGKNKEPVKQAVPTET ENTVVKQEANNDESNETIVIDIKGAVQHPGVYEMRTGDRVSQAIEKAGGTSEQADEAQ VNLAEILQDGTVVYIPKKGEETAVQQGGGGSVQSDGGKGALVNINTATLEELQGISGV GPSKAEAIIAYREENGRFQTIEDITKVSGIGEKSFEKIKSSITVK*" /label="comEA CDS" gene complement(2239442..2240059) /gene="comEA" /locus_tag="BSU_25590" /old_locus_tag="BSU25590" /label="comEA gene" promotor_-35 2240080..2240085 /Source="Nicolas_upshift_promotors" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2240097 /Source="Nicolas_upshifts" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2240101..2240119 /Source="Nicolas_upshift_promotors" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2240120..2240134) /Source="Nicolas_upshift_promotors" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2240122) /Source="Nicolas_upshifts" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2240124..2240971) /Source="Nicolas_S_feature" /locus_tag="new_2641195_2642042_c" /HighExp="C30, T0.30H, T-2.40H, GM 150, T1.30H, T-0.40H, T-1.10H, T-1.40H, T1.0H, T0.0H" /AntisenseName="comER" /AntisenseCor="-8.2389039371154299E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S963" promotor_-35 complement(2240143..2240147) /Source="Nicolas_upshift_promotors" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2240143..2240964 /gene="comER" /locus_tag="BSU_25600" /old_locus_tag="BSU25600" /EC_number="1.5.1.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7968523, 11418582, 27446060, 28824574; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pyrroline-5'-carboxylate reductase" /protein_id="NP_390438.1" /db_xref="EnsemblGenomes-Gn:BSU25600" /db_xref="EnsemblGenomes-Tr:CAB14502" /db_xref="GOA:P39696" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10479" /db_xref="UniProtKB/Swiss-Prot:P39696" /translation="MKIGFIGTGNMGTILIESFIESKAADPSNMTITNRTIEKALHIK NRYNSINVTESLEKLVSENEMIFICVKPLDIYPLLARALPYLRKDHILISITSPVQTE QLEQYVPCQVARVIPSITNRALAGVSLVTFGTSCGESAKAKINELMQHISHPLQIESD ITRVASDIVSCGPAFMSYLIQRFIDAAVSETSVSKQDAILMCKEMLVGMGKLLETELY TLPALQEKVCVKGGVTGEGIKALESGVQDMFHRVFQNTHMKYEEDISAVKKQFHV*" /label="comER CDS" gene 2240143..2240964 /gene="comER" /locus_tag="BSU_25600" /old_locus_tag="BSU25600" /label="comER gene" promotor_-10 complement(2240959..2240978) /Source="Nicolas_upshift_promotors" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2240965..2241045 /Source="Nicolas_S_feature" /locus_tag="new_2642036_2642116" /HighExp="S4, S5, S3, S6, S7, B36, Pyr, G/S, S8, BT" /AntisenseName="yqeM" /AntisenseCor="-0.52267300854840604" /AntisenseRegPval="-19.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S964" upshifts complement(2240972) /Source="Nicolas_upshifts" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2240992..2240999) /Source="Nicolas_upshift_promotors" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2241005 /Source="Nicolas_upshifts" /id="D1325" /incds=0 /nref=45 /ntot=64 /MaxReadThrough="2.4803" /MaxDrop="5.1403" /score="7.09525061" /energy="-10.5" /TU="NA" /idTUdmin="U1993" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2241030..2241773) /gene="yqeM" /locus_tag="BSU_25610" /old_locus_tag="BSU25610" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_390439.1" /db_xref="EnsemblGenomes-Gn:BSU25610" /db_xref="EnsemblGenomes-Tr:CAB14503" /db_xref="GOA:P54458" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11641" /db_xref="UniProtKB/Swiss-Prot:P54458" /translation="MIYQGFASVYDELMSHAPYDQWTKWIEASLPEKGRILDLACGTG EISIRLAEKGFEVTGIDLSEEMLSFAQQKVSSSQPILFLQQDMREITGFDGQFDAVVI CCDSLNYLKTKNDVIETFKSVFRVLKPEGILLFDVHSSFKIAEVFPDSTFADQDEDIS YIWQSFAGSDELSVIHDMSFFVWNGEAYDRFDETHEQRTFPVEEYEEMLKNCGFQLHR VTADFTDTEPSAQSERLFFKAQKSKTIVS*" /label="yqeM CDS" gene complement(2241030..2241773) /gene="yqeM" /locus_tag="BSU_25610" /old_locus_tag="BSU25610" /label="yqeM gene" downshifts complement(2241060) /Source="Nicolas_upshifts" /id="D1326" /incds=0 /nref=144 /ntot=230 /MaxReadThrough="1.41467" /MaxDrop="5.51802" /score="7.9251293" /energy="-10.5" /TU="NA" /idTUdmin="U1996" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2241770..2242126) /gene="rsfS" /locus_tag="BSU_25620" /old_locus_tag="BSU25620" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15044829, 16980477, 22238375, 22238376, 22829778, 26299947; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal silencing factor" /protein_id="NP_390440.1" /db_xref="EnsemblGenomes-Gn:BSU25620" /db_xref="EnsemblGenomes-Tr:CAB14504" /db_xref="GOA:P54457" /db_xref="InterPro:IPR004394" /db_xref="SubtiList:BG11640" /db_xref="UniProtKB/Swiss-Prot:P54457" /translation="MNQKSILKIAAAACDDKRAEDILALDMEGISLVADYFLICHGNS DKQVQAIAREIKDQADENGIQVKKMEGFDEARWVLVDLGDVVVHVFHKDERSYYNLEK LWGDAPLADLDFGMNQ*" /label="rsfS CDS" gene complement(2241770..2242126) /gene="rsfS" /locus_tag="BSU_25620" /old_locus_tag="BSU25620" /label="rsfS gene" CDS complement(2242144..2242704) /gene="yqeK" /locus_tag="BSU_25630" /old_locus_tag="BSU25630" /function="16.2: Construct biomass (Anabolism)" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390441.1" /db_xref="EnsemblGenomes-Gn:BSU25630" /db_xref="EnsemblGenomes-Tr:CAB14505" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR005249" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG11639" /db_xref="UniProtKB/Swiss-Prot:P54456" /translation="MNREEALACVKQQLTEHRYIHTVGVMNTAIELAERFGADSKKAE IAAIFHDYAKFRPKEEMKQIIAREKMPAHLLDHNPELWHAPVGAYLVQREAGVQDEDI LDAIRYHTSGRPGMTLLEKVIYVADYIEPNRAFPGVDEVRKLAETDLNQALIQSIKNT MVFLMKKNQPVFPDTFLTYNWLVSGS*" /label="yqeK CDS" gene complement(2242144..2242704) /gene="yqeK" /locus_tag="BSU_25630" /old_locus_tag="BSU25630" /label="yqeK gene" CDS complement(2242694..2243263) /gene="nadD" /locus_tag="BSU_25640" /old_locus_tag="BSU25640" /EC_number="2.7.7.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11704676, 12682299, 19716475, 23204464, 25631047; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate-nucleotide adenylyltransferase" /protein_id="NP_390442.1" /db_xref="EnsemblGenomes-Gn:BSU25640" /db_xref="EnsemblGenomes-Tr:CAB14506" /db_xref="GOA:P54455" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR005248" /db_xref="InterPro:IPR014729" /db_xref="PDB:1KAM" /db_xref="PDB:1KAQ" /db_xref="SubtiList:BG11638" /db_xref="UniProtKB/Swiss-Prot:P54455" /translation="MKKIGIFGGTFDPPHNGHLLMANEVLYQAGLDEIWFMPNQIPPH KQNEDYTDSFHRVEMLKLAIQSNPSFKLELVEMEREGPSYTFDTVSLLKQRYPNDQLF FIIGADMIEYLPKWYKLDELLNLIQFIGVKRPGFHVETPYPLLFADVPEFEVSSTMIR ERFKSKKPTDYLIPDKVKKYVEENGLYES*" /label="nadD CDS" gene complement(2242694..2243263) /gene="nadD" /locus_tag="BSU_25640" /old_locus_tag="BSU25640" /label="nadD gene" CDS complement(2243275..2243565) /gene="yqeI" /locus_tag="BSU_25650" /old_locus_tag="BSU25650" /experiment="publication(s) with functional evidences, PMID:12682299, 16014871, 17005971, 17105995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16014871, 17005971, 17105995; Product type f: factor" /codon_start=1 /transl_table=11 /product="50S RNA-binding protein" /protein_id="NP_390443.1" /db_xref="EnsemblGenomes-Gn:BSU25650" /db_xref="EnsemblGenomes-Tr:CAB14507" /db_xref="GOA:P54454" /db_xref="InterPro:IPR001890" /db_xref="InterPro:IPR017924" /db_xref="InterPro:IPR035920" /db_xref="SubtiList:BG11637" /db_xref="UniProtKB/Swiss-Prot:P54454" /translation="MLTGKQKRFLRSKAHHLTPIFQVGKGGVNDNMIKQIAEALEARE LIKVSVLQNCEEDKNDVAEALVKGSRSQLVQTIGNTIVLYKESKENKQIELP*" /label="yqeI CDS" gene complement(2243275..2243565) /gene="yqeI" /locus_tag="BSU_25650" /old_locus_tag="BSU25650" /label="yqeI gene" CDS complement(2243559..2244401) /gene="aroE" /locus_tag="BSU_25660" /old_locus_tag="BSU25660" /EC_number="1.1.1.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2104604, 12906820, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="shikimate 5-dehydrogenase" /protein_id="NP_390444.2" /db_xref="EnsemblGenomes-Gn:BSU25660" /db_xref="EnsemblGenomes-Tr:CAB14508" /db_xref="GOA:P54374" /db_xref="InterPro:IPR006151" /db_xref="InterPro:IPR011342" /db_xref="InterPro:IPR013708" /db_xref="InterPro:IPR022893" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11522" /db_xref="UniProtKB/Swiss-Prot:P54374" /translation="MKKLYGVIGNPIGHSMSPDIHNASLKDLGLDGHYHAFKVEENDL EDAVKGIRALGVQGINVTVPHKVSIMDYLDHIDESAKVLGAVNTVRREGDKLVGYNTD GEGFVKSLMKVLDKPISELSFLMIGAGGAARAIFTTIVRNTPKKFDICNRTLEKAKRL TEATPSFHNKEVLSIKEAEERLEQYDVIIHTTSVGMYPNVDDVPLSLQRAASSAVVCD IVYNPIQTALLKEASQKGLKTLDGVGMFVEQAALSFQLWTGQEPNIEKMRSIVIGKLG GTEC*" /label="aroE CDS" gene complement(2243559..2244401) /gene="aroE" /locus_tag="BSU_25660" /old_locus_tag="BSU25660" /label="aroE gene" downshifts 2244393 /Source="Nicolas_upshifts" /id="D1327" /incds=0 /nref=2 /ntot=118 /MaxReadThrough="0.240279999999999" /MaxDrop="3.04009" /score="0.0642154872" /energy="-17" /TU="NA" /idTUdmin="U1993" /TUdmin=3388 /isTUend="FALSE" /label="downshifts" CDS complement(2244419..2245519) /gene="rgpH" /locus_tag="BSU_25670" /old_locus_tag="BSU25670" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12427945, 12682299, 17237168, 17895579, 18801747, 19540197, 20376346, 22750478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12427945, 12682299, 17237168, 17895579, 18801747, 19540197, 20376346, 22750478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="potassium-dependent GTPase involved in ribosome 30S assembly" /protein_id="NP_390445.1" /db_xref="EnsemblGenomes-Gn:BSU25670" /db_xref="EnsemblGenomes-Tr:CAB14509" /db_xref="GOA:P54453" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR019988" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="SubtiList:BG11636" /db_xref="UniProtKB/Swiss-Prot:P54453" /translation="MEKVVCIGCGVTIQTEDKTGLGYAPPASLTKENVICQRCFRLKN YNEIQDVSLTDDDFLNILHGIGETDSLVVKIVDIFDFNGSWINGLQRLVGGNPILLVG NKADILPKSLKRERLIQWMKREAKELGLKPVDVFLVSAGRGQGIREVIDAIEHYRNGK DVYVVGCTNVGKSTFINRIIKEVSGEEDIITTSQFPGTTLDAIEIPLDDGSSLYDTPG IINNHQMAHYVNKKDLKILSPKKELKPRTFQLNDQQTLYFGGLARFDYVSGERSPFIC YMPNELMIHRTKLENADALYEKHAGELLTPPGKDEMDEFPELVAHTFTIKDKKTDIVF SGLGWVTVHDADKKVTAYAPKGVHVFVRRSLI*" /label="rgpH CDS" gene complement(2244419..2245519) /gene="rgpH" /locus_tag="BSU_25670" /old_locus_tag="BSU25670" /label="rgpH gene" CDS complement(2245523..2246041) /gene="yqeG" /locus_tag="BSU_25680" /old_locus_tag="BSU25680" /EC_number="3.1.3.-" /experiment="publication(s) with functional evidences, PMID:27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatase (active on GMP and Glc-6-P)" /protein_id="NP_390446.1" /db_xref="EnsemblGenomes-Gn:BSU25680" /db_xref="EnsemblGenomes-Tr:CAB14510" /db_xref="GOA:P54452" /db_xref="InterPro:IPR006356" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR006549" /db_xref="InterPro:IPR010021" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11635" /db_xref="UniProtKB/Swiss-Prot:P54452" /translation="MLKKFFLPDEFVKNIFHITPEKLKERNVKGIITDLDNTLVEWDR PNATPRLIEWFEEMKEHGIKVTIVSNNNERRVKLFSEPLGIPFIYKARKPMGKAFNRA VRNMELKKEDCVVIGDQLLTDVLGGNRNGYHTILVVPVASSDGFITRFNRQVERRILS ALKRKGHIQWEE*" /label="yqeG CDS" gene complement(2245523..2246041) /gene="yqeG" /locus_tag="BSU_25680" /old_locus_tag="BSU25680" /label="yqeG gene" promotor_-10 complement(2245951..2245968) /Source="Nicolas_upshift_promotors" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2245965) /Source="Nicolas_upshifts" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2245984..2245987) /Source="Nicolas_upshift_promotors" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2246042..2246603) /Source="Nicolas_S_feature" /locus_tag="new_2647113_2647674_c" /HighExp="G135, G180, G150, Paraq, Oxctl, C30, Heat, HPh, BMM, LPh" /AntisenseName="sda" /AntisenseCor="-8.6107693225382295E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S965" downshifts complement(2246075) /Source="Nicolas_upshifts" /id="D1328" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="6.83118" /MaxDrop="5.26138" /score="9.20556883" /energy="-8.6" /TU="U1998" /idTUdmin="U1999" /TUdmin=616 /isTUend="FALSE" /label="downshifts" promotor_-35 2246266..2246273 /Source="Nicolas_upshift_promotors" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2246284..2246384 /Source="Nicolas_S_feature" /locus_tag="new_2647355_2647455" /HighExp="T3.0H, T-0.40H, MG 150, T5.0H, T-1.40H, T4.0H, T2.30H, T0.0H, T3.30H, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S966" promotor_-10 2246284..2246303 /Source="Nicolas_upshift_promotors" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2246284 /Source="Nicolas_upshifts" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="upshifts" misc_RNA complement(2246334..2246592) /gene="sdaM" /locus_tag="BSU_misc_RNA_80" /product="antisense RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="sdaM RNA" gene complement(2246334..2246592) /gene="sdaM" /locus_tag="BSU_misc_RNA_80" /label="sdaM gene" CDS 2246385..2246543 /gene="sda" /locus_tag="BSU_25690" /old_locus_tag="BSU25690" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15023339, 16796683, 19040634, 22720735, 28752667" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15023339, 16796683, 19040634, 22720735, 28752667; Product type f: factor" /codon_start=1 /transl_table=11 /product="check point factor coupling initiation of sporulation and replication initiation" /protein_id="YP_054588.1" /db_xref="EnsemblGenomes-Gn:BSU25690" /db_xref="EnsemblGenomes-Tr:CAE01463" /db_xref="GOA:Q7WY62" /db_xref="InterPro:IPR015064" /db_xref="InterPro:IPR036916" /db_xref="PDB:1PV0" /db_xref="PDB:3FYR" /db_xref="SubtiList:BG14183" /db_xref="UniProtKB/Swiss-Prot:Q7WY62" /translation="MNWVPSMRKLSDELLIESYFKATEMNLNRDFIELIENEIKRRSL GHIISVSS*" /label="sda CDS" gene 2246385..2246543 /gene="sda" /locus_tag="BSU_25690" /old_locus_tag="BSU25690" /label="sda gene" S_feature 2246544..2246790 /Source="Nicolas_S_feature" /locus_tag="new_2647615_2647861" /HighExp="Cold, T-0.40H, MG 150, T5.0H, T4.0H, C30, T2.30H, M9-tran, S2, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S967" promotor_-10 complement(2246591..2246610) /Source="Nicolas_upshift_promotors" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2246602) /Source="Nicolas_upshifts" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2246626..2246630) /Source="Nicolas_upshift_promotors" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2246654..2246801) /Source="Nicolas_S_feature" /locus_tag="new_2647725_2647872_c" /HighExp="S8, S7, S6, Etha, LBGstat, T0.30H, Salt, BT, LPhT, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99948400000000004" /TUshortSig="SigK, SigA, SigB" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S968" downshifts complement(2246691) /Source="Nicolas_upshifts" /id="D1329" /incds=0 /nref=12 /ntot=92 /MaxReadThrough="2.70676" /MaxDrop="4.386" /score="9.20556883" /energy="-8.6" /TU="NA" /idTUdmin="U1999" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 2246747 /Source="Nicolas_upshifts" /id="D1330" /incds=0 /nref=1 /ntot=126 /MaxReadThrough="5.36291" /MaxDrop="2.1106" /score="10.3636587" /energy="-6.2" /TU="U1997" /idTUdmin="U1997" /TUdmin="-1056" /isTUend="FALSE" /label="downshifts" S_feature 2246792..2247845 /Source="Nicolas_S_feature" /locus_tag="new_2647863_2648916" /HighExp="T-0.40H, Cold, M40t90, T0.0H, C30, Glucon, S2, T1.30H, T2.30H, T2.0H" /AntisenseName="yqeF" /AntisenseCor="-0.39616310996746001" /AntisenseRegPval="-10.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S969" promotor_-10 complement(2246796..2246815) /Source="Nicolas_upshift_promotors" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2246801) /Source="Nicolas_upshifts" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2246828..2246837) /Source="Nicolas_upshift_promotors" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2246849..2247580) /gene="yqeF" /locus_tag="BSU_25700" /old_locus_tag="BSU25700" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lipoprotein; putative esterase" /protein_id="NP_390447.1" /db_xref="EnsemblGenomes-Gn:BSU25700" /db_xref="EnsemblGenomes-Tr:CAB14511" /db_xref="GOA:P54451" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG11634" /db_xref="UniProtKB/Swiss-Prot:P54451" /translation="MKHFIILFLLLFVTAGCEGRGYEDVVAFGDSNTRGSNWDYRDYP KAQQWVNILKTAERGNLDILNAGIGGQTTEDARLRFQTDVLDQKPKYLFIMFGTNDAA ILTEGKPRVSKQRFRENLVYFIEESRKHGIKPILMTCIPIIEGNGKHHLFYYSRYQAA AFEPKGGARKWHNSYNDITRDVSKRLDVPLVDNWKHFIEADGGKATDEALIQSGLIDP SGNHMTPKGARIVYEGIQDGQILQR*" /label="yqeF CDS" gene complement(2246849..2247580) /gene="yqeF" /locus_tag="BSU_25700" /old_locus_tag="BSU25700" /label="yqeF gene" promotor_-10 complement(2247599..2247618) /Source="Nicolas_upshift_promotors" /id="U2000" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.380619380619381" /psig=1 /xcortree=2739 /SigmaFactorBS="taactataggaaaaaacagtgatagcgaaaaactcttCATTG AAcgaagagaaacagAGGTATAACATTAAAGTGAGgcttttgggggtgtaaagatgaa a" /listShort="yqeF, S968" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2247615) /Source="Nicolas_upshifts" /id="U2000" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.380619380619381" /psig=1 /xcortree=2739 /SigmaFactorBS="taactataggaaaaaacagtgatagcgaaaaactcttCATTG AAcgaagagaaacagAGGTATAACATTAAAGTGAGgcttttgggggtgtaaagatgaa a" /listShort="yqeF, S968" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2247617..2247725) /Source="Nicolas_S_feature" /locus_tag="new_2648688_2648796_c" /HighExp="Etha, Salt, Gly, S8, C30, S7, LPhT, Sw, Heat, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S970" promotor_-35 complement(2247632..2247638) /Source="Nicolas_upshift_promotors" /id="U2000" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.380619380619381" /psig=1 /xcortree=2739 /SigmaFactorBS="taactataggaaaaaacagtgatagcgaaaaactcttCATTG AAcgaagagaaacagAGGTATAACATTAAAGTGAGgcttttgggggtgtaaagatgaa a" /listShort="yqeF, S968" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2247726..2247744) /Source="Nicolas_upshift_promotors" /id="U2001" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=162 /SigmaFactorBS="tttccagtgcggattcaggttattttcttttctttggtttgt gTGTTTTtcagattggaaagaAGGGAATTTTAAAAAATCAtcagctgcgccgcaatga a" /listShort="S970, yqeF, S968" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2247747) /Source="Nicolas_upshifts" /id="U2001" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=162 /SigmaFactorBS="tttccagtgcggattcaggttattttcttttctttggtttgt gTGTTTTtcagattggaaagaAGGGAATTTTAAAAAATCAtcagctgcgccgcaatga a" /listShort="S970, yqeF, S968" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2247759..2247764) /Source="Nicolas_upshift_promotors" /id="U2001" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=162 /SigmaFactorBS="tttccagtgcggattcaggttattttcttttctttggtttgt gTGTTTTtcagattggaaagaAGGGAATTTTAAAAAATCAtcagctgcgccgcaatga a" /listShort="S970, yqeF, S968" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2247832..2248584) /gene="cwlH" /locus_tag="BSU_25710" /old_locus_tag="BSU25710" /EC_number="3.5.1.28" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10515909, 10974124, 15687192" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10515909, 10974124, 15687192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_390448.1" /db_xref="EnsemblGenomes-Gn:BSU25710" /db_xref="EnsemblGenomes-Tr:CAB14512" /db_xref="GOA:P54450" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR002502" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="InterPro:IPR036505" /db_xref="SubtiList:BG11633" /db_xref="UniProtKB/Swiss-Prot:P54450" /translation="MVTIKKDFIPVSNDNRPGYAMAPAYITVHNTANTAKGADAKMHA KFVKNPNTSESWHFTVDDSVIYQHLPIDENGWHAGDGTNGTGNRKSIGIEICENADGD FEKATSNAQWLIRKLMKENNIPLNRVVPHKKWSGKECPRKLLDHWNSFLNGISSSDTP PKETSPSYPLPSGVIKLTSPYRKGTNILQLQKALAVLHFYPDKGAKNNGIDGVYGPKT ANAVKRFQLMNGLTADGIYGPKTKAKLKSKLK*" /label="cwlH CDS" gene complement(2247832..2248584) /gene="cwlH" /locus_tag="BSU_25710" /old_locus_tag="BSU25710" /label="cwlH gene" downshifts complement(2247835) /Source="Nicolas_upshifts" /id="D1331" /incds=0 /nref=4 /ntot=10 /MaxReadThrough="1.29819" /MaxDrop="4.65121" /score="4.6304411" /energy="-10.7" /TU="NA" /idTUdmin="U2003" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2247963..2247969 /Source="Nicolas_upshift_promotors" /id="U2002" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=171 /SigmaFactorBS="ctgttttcggtccgtaaactccatctatgccatTGTTTTTgg ctcccttatcaGGGTAAAAGTGAAGTACAGctaaagccttttgcagctggagaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2247983..2248001 /Source="Nicolas_upshift_promotors" /id="U2002" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=171 /SigmaFactorBS="ctgttttcggtccgtaaactccatctatgccatTGTTTTTgg ctcccttatcaGGGTAAAAGTGAAGTACAGctaaagccttttgcagctggagaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2247990 /Source="Nicolas_upshifts" /id="U2002" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=171 /SigmaFactorBS="ctgttttcggtccgtaaactccatctatgccatTGTTTTTgg ctcccttatcaGGGTAAAAGTGAAGTACAGctaaagccttttgcagctggagaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2248594..2248613) /Source="Nicolas_upshift_promotors" /id="U2003" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.898101898101898" /psig="0.898101898101898" /xcortree=1426 /SigmaFactorBS="caggttaagaacacaattcttttttacctcataaaaaaGGCT GTCCAtctctctgttttcTGCATTCTTATTAATAGGGAgggatagaaatggtaaccat a" /listShort="cwlH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2248613) /Source="Nicolas_upshifts" /id="U2003" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.898101898101898" /psig="0.898101898101898" /xcortree=1426 /SigmaFactorBS="caggttaagaacacaattcttttttacctcataaaaaaGGCT GTCCAtctctctgttttcTGCATTCTTATTAATAGGGAgggatagaaatggtaaccat a" /listShort="cwlH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2248627..2248635) /Source="Nicolas_upshift_promotors" /id="U2003" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.898101898101898" /psig="0.898101898101898" /xcortree=1426 /SigmaFactorBS="caggttaagaacacaattcttttttacctcataaaaaaGGCT GTCCAtctctctgttttcTGCATTCTTATTAATAGGGAgggatagaaatggtaaccat a" /listShort="cwlH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2248679..2248686 /Source="Nicolas_upshift_promotors" /id="U2004" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1830 /SigmaFactorBS="aggtaaaaaagaattgtgttcttaacctggttttCAGTTGAA cagctgaaatggcaCCAGTTATACTAATTTAGATgacggaggttttgactcctgacat c" /listShort="S971, yqeD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2248701..2248720 /Source="Nicolas_upshift_promotors" /id="U2004" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1830 /SigmaFactorBS="aggtaaaaaagaattgtgttcttaacctggttttCAGTTGAA cagctgaaatggcaCCAGTTATACTAATTTAGATgacggaggttttgactcctgacat c" /listShort="S971, yqeD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2248705..2248770 /Source="Nicolas_S_feature" /locus_tag="new_2649776_2649841" /HighExp="dia15, H2O2, C30, G180, Heat, S8, Paraq, Oxctl, LBGexp, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S971" upshifts 2248705 /Source="Nicolas_upshifts" /id="U2004" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1830 /SigmaFactorBS="aggtaaaaaagaattgtgttcttaacctggttttCAGTTGAA cagctgaaatggcaCCAGTTATACTAATTTAGATgacggaggttttgactcctgacat c" /listShort="S971, yqeD" /GFF_Attribute="listLong" /label="upshifts" CDS 2248771..2249397 /gene="yqeD" /locus_tag="BSU_25720" /old_locus_tag="BSU25720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 15855514, 16850406" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390449.1" /db_xref="EnsemblGenomes-Gn:BSU25720" /db_xref="EnsemblGenomes-Tr:CAB14513" /db_xref="GOA:P54449" /db_xref="InterPro:IPR015414" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG11632" /db_xref="UniProtKB/Swiss-Prot:P54449" /translation="MLKKVIGILVIIAIISVGFFQKEAWLDAIKAGGMFSVLFSMLLI AADVFFPIVPFALIAALNGAVFGTANGIWITLTGSMLGTILLFFLARYSFRDWARKKV QAYPAIQSYEASFNKNAFTAVLLGRLIPVIPSLVMNVICGLSQVRWHVFFFASLIGKI PNIVVVTIAGANFTSNKLLSISIYGTYILIIMLVIYKKFPHLLKVPKK*" /label="yqeD CDS" gene 2248771..2249397 /gene="yqeD" /locus_tag="BSU_25720" /old_locus_tag="BSU25720" /label="yqeD gene" downshifts 2249365 /Source="Nicolas_upshifts" /id="D1332" /incds=0 /nref=2 /ntot=63 /MaxReadThrough="2.9326" /MaxDrop="2.91074" /score="15.7108141" /energy="-10.3" /TU="U2004" /idTUdmin="U2004" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2249416..2250309) /gene="yqeC" /locus_tag="BSU_25730" /old_locus_tag="BSU25730" /EC_number="1.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10658669, 15231785; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative catabolic 6-phospho-gluconate dehydrogenase (NAD[+]-dependent)" /protein_id="NP_390450.1" /db_xref="EnsemblGenomes-Gn:BSU25730" /db_xref="EnsemblGenomes-Tr:CAB14514" /db_xref="GOA:P54448" /db_xref="InterPro:IPR004849" /db_xref="InterPro:IPR006114" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR006183" /db_xref="InterPro:IPR006184" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11631" /db_xref="UniProtKB/Swiss-Prot:P54448" /translation="MKIGLIGLGKMGINIGKQFIDRNHQVVGYDVNQAAVDELKAYGA EGTTNLKEFISLLHPPRILWVMVPHGIVDAVLRDVSPLLSKGDMIIEAGNSHYKESIR RYNQMKEAGIHYLDAGTSGGMEGARHGACFMVGGDHEAWEIVEPLFRDTAVENGYLYA GEAGSGHFLKMIHNGIEYGMMAAIGEGFEVLENSQFDFDYEKVARVWNHGSVIRSWLM GLTERAFAKDAKLDQIKGIMHSSGEGKWTVETALDLQTATPVIAMSLMMRYRSLTDDT FTGKVVAALRNEFGGHATEKK*" /label="yqeC CDS" gene complement(2249416..2250309) /gene="yqeC" /locus_tag="BSU_25730" /old_locus_tag="BSU25730" /label="yqeC gene" downshifts complement(2249441) /Source="Nicolas_upshifts" /id="D1333" /incds=0 /nref=4 /ntot=12 /MaxReadThrough="1.46947" /MaxDrop="3.03963" /score="0.698755756" /energy="-8.4" /TU="NA" /idTUdmin="U2003" /TUdmin="-1606" /isTUend="FALSE" /label="downshifts" promotor_-35 2250492..2250498 /Source="Nicolas_upshift_promotors" /id="U2005" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.874125874125874" /psig="0.998001998001998" /xcortree=3104 /SigmaFactorBS="tctattactgaatctctttatatccataattatcgctttatc CTTGATTtaccatcagttTAAGTTAAAATATGGGAAGGaattcgattttttcagtaaa a" /listShort="yqeB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2250510..2250529 /Source="Nicolas_upshift_promotors" /id="U2005" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.874125874125874" /psig="0.998001998001998" /xcortree=3104 /SigmaFactorBS="tctattactgaatctctttatatccataattatcgctttatc CTTGATTtaccatcagttTAAGTTAAAATATGGGAAGGaattcgattttttcagtaaa a" /listShort="yqeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2250510 /Source="Nicolas_upshifts" /id="U2005" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.874125874125874" /psig="0.998001998001998" /xcortree=3104 /SigmaFactorBS="tctattactgaatctctttatatccataattatcgctttatc CTTGATTtaccatcagttTAAGTTAAAATATGGGAAGGaattcgattttttcagtaaa a" /listShort="yqeB" /GFF_Attribute="listLong" /label="upshifts" CDS 2250561..2251283 /gene="yqeB" /locus_tag="BSU_25740" /old_locus_tag="BSU25740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390451.2" /db_xref="EnsemblGenomes-Gn:BSU25740" /db_xref="EnsemblGenomes-Tr:CAB14515" /db_xref="GOA:P54447" /db_xref="SubtiList:BG11630" /db_xref="UniProtKB/Swiss-Prot:P54447" /translation="MLQNQSHTLIGVTKTAVFFLYAALAIIGFAIGYFIPQIAKWALS LPWIPLEGPLRLITSFQGSTASFITALLGMCAGIWFAHSVIAMLLSVKITDHTVEFIK GKKVQTIHSDDIALVFMDHKRLVLLGTAGYELVREEIDEKPVNVEKAFRQHHYEWATD GDPFKDQFRRWIPDAPDLSQGAHALLKARHKALQDEEKDDIEEFRLELAQLGIVVRDE GTRQYWRKAETYPPKIQLGEGL*" /label="yqeB CDS" gene 2250561..2251283 /gene="yqeB" /locus_tag="BSU_25740" /old_locus_tag="BSU25740" /label="yqeB gene" CDS complement(2251316..2251726) /gene="nucB" /locus_tag="BSU_25750" /old_locus_tag="BSU25750" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7746143, 17209033, 21179489" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7746143, 17209033, 21179489; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation-specific matrix degrading exported DNase" /protein_id="NP_390452.1" /db_xref="EnsemblGenomes-Gn:BSU25750" /db_xref="EnsemblGenomes-Tr:CAB14516" /db_xref="GOA:P42983" /db_xref="InterPro:IPR029476" /db_xref="SubtiList:BG11237" /db_xref="UniProtKB/Swiss-Prot:P42983" /translation="MKKWMAGLFLAAAVLLCLMVPQQIQGASSYDKVLYFPLSRYPET GSHIRDAIAEGHPDICTIDRDGADKRREESLKGIPTKPGYDRDEWPMAVCEEGGAGAD VRYVTPSDNRGAGSWVGNQMSSYPDGTRVLFIVQ*" /label="nucB CDS" gene complement(2251316..2251726) /gene="nucB" /locus_tag="BSU_25750" /old_locus_tag="BSU25750" /label="nucB gene" downshifts complement(2251341) /Source="Nicolas_upshifts" /id="D1334" /incds=0 /nref=2 /ntot=20 /MaxReadThrough="0.80212" /MaxDrop="3.40706" /score="-0.144589925" /energy="-9.3" /TU="NA" /idTUdmin="U2006" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2251746..2251764) /Source="Nicolas_upshift_promotors" /id="U2006" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1115 /SigmaFactorBS="cagcatactaacttcaaatgttaAAAATAttcttcatcaagc gcCCATACATTGAAATGAACAaaggtatggggggatggggatgaaaaaatggatggca g" /listShort="nucB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2251748) /Source="Nicolas_upshifts" /id="U2006" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1115 /SigmaFactorBS="cagcatactaacttcaaatgttaAAAATAttcttcatcaagc gcCCATACATTGAAATGAACAaaggtatggggggatggggatgaaaaaatggatggca g" /listShort="nucB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2251780..2251785) /Source="Nicolas_upshift_promotors" /id="U2006" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1115 /SigmaFactorBS="cagcatactaacttcaaatgttaAAAATAttcttcatcaagc gcCCATACATTGAAATGAACAaaggtatggggggatggggatgaaaaaatggatggca g" /listShort="nucB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2251849..2251857 /Source="Nicolas_upshift_promotors" /id="U2007" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1062 /SigmaFactorBS="ttaccaaagccggactcccccgcgagaaatttcccggtaCAG ACACAGacagcctcccggtCACATACATTTACATATAGGcttttgcctacatactttt g" /listShort="spoIVCB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2251870 /Source="Nicolas_upshifts" /id="U2007" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1062 /SigmaFactorBS="ttaccaaagccggactcccccgcgagaaatttcccggtaCAG ACACAGacagcctcccggtCACATACATTTACATATAGGcttttgcctacatactttt g" /listShort="spoIVCB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2251871..2251890 /Source="Nicolas_upshift_promotors" /id="U2007" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1062 /SigmaFactorBS="ttaccaaagccggactcccccgcgagaaatttcccggtaCAG ACACAGacagcctcccggtCACATACATTTACATATAGGcttttgcctacatactttt g" /listShort="spoIVCB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2251922..2252392 /gene="sigKn" /locus_tag="BSU_25760" /old_locus_tag="BSU25760" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8464402, 7704261, 2536191, 2163341, 10974124, 15187183, 20889742" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8464402, 7704261, 2536191, 2163341, 10974124, 15187183, 20889742; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="RNA polymerase sporulation-specific sigma-K factor precursor (Sigma-27) (N-terminal half)" /db_xref="GOA:P12254" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="PSEUDO:CAB14517.2" /db_xref="SubtiList:BG10459" /db_xref="UniProtKB/Swiss-Prot:P12254" /translation="MVTGVFAALGFVVKELVFLVSYVKNNAFPQPLSSSEEKKYLELM AKGDEHARNMLIEHNLRLVAHIVKKFENTGEDAEDLISIGTIGLIKGIESYSAGKGTK LATYAARCIENEIVITKGGCIHPSLIRFNIYGVRIHNGNFFHDKVNNCFFIFKS*" /label="sigKn CDS" gene 2251922..2252392 /gene="sigKn" /locus_tag="BSU_25760" /old_locus_tag="BSU25760" /pseudo /label="sigKn gene" downshifts 2252112 /Source="Nicolas_upshifts" /id="D1335" /incds=1 /nref=2 /ntot=5 /MaxReadThrough="7.53734" /MaxDrop="3.01863" /score="-7.46047649" /energy="-12.1" /TU="U2007" /idTUdmin="U2007" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts 2252244 /Source="Nicolas_upshifts" /id="D1336" /incds=1 /nref=44 /ntot=61 /MaxReadThrough="0.8049" /MaxDrop="7.21386" /score="-7.46047649" /energy="-12.1" /TU="NA" /idTUdmin="U2007" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2252300..2253802) /gene="spoIVCA" /locus_tag="BSU_25770" /old_locus_tag="BSU25770" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1631085, 2163341, 7704261, 8300549, 8969508, 8655528, 18673456" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1631085, 2163341, 7704261, 8300549, 8969508, 8655528, 18673456; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="site-specific DNA recombinase; skin element" /protein_id="NP_390454.2" /db_xref="EnsemblGenomes-Gn:BSU25770" /db_xref="EnsemblGenomes-Tr:CAB14518" /db_xref="GOA:P17867" /db_xref="InterPro:IPR006118" /db_xref="InterPro:IPR006119" /db_xref="InterPro:IPR011109" /db_xref="InterPro:IPR025827" /db_xref="InterPro:IPR036162" /db_xref="SubtiList:BG10458" /db_xref="UniProtKB/Swiss-Prot:P17867" /translation="MIAIYVRVSTEEQAIKGSSIDSQIEACIKKAGTKDVLKYADEGF SGELLERPALNRLREDASKGLISQVICYDPDRLSRKLMNQLIIDDELRKRNIPLIFVN GEYANSPEGQLFFAMRGAISEFEKAKIKERTSSGRLQKMKKGMIIKDSKLYGYKFVKE KRTLEILEEEAKIIRMIFNYFTDHKSPFFGRVNGIALHLTQMGVKTKKGAKVWHRQVV RQILMNSSYKGEHRQYKYDTEGSYVSKQAGNKSIIKIRPEEEQITVTIPAIVPAEQWD YAQELLGQSKRKHLSISPHNYLLSGLVRCGKCGNTMTGKKRKSHGKDYYVYTCRKNYS GAKDRGCGKEMSENKLNRHVWGEIFKFITNPQKYVSFKEAEQSNHLSDELELIEKEIE KTKKGRKRLLTLISLSDDDDLDIDEIKAQIIELQKKQNQLTEKCNEIQSKMKVLDDTS SSENALKRAIDYFQSIGADNLTLEDKKTIVNFIVKEVTIVDSDTIYIETY*" /label="spoIVCA CDS" gene complement(2252300..2253802) /gene="spoIVCA" /locus_tag="BSU_25770" /old_locus_tag="BSU25770" /label="spoIVCA gene" downshifts complement(2252316) /Source="Nicolas_upshifts" /id="D1337" /incds=1 /nref=21 /ntot=131 /MaxReadThrough="2.50085" /MaxDrop="6.35891" /score="-0.144589925" /energy="-9.3" /TU="NA" /idTUdmin="U2008" /TUdmin=4 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2253909..2253927) /Source="Nicolas_upshift_promotors" /id="U2008" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1098 /SigmaFactorBS="gaaacgtttaataacactatagtttaatttaaaatctcCTCA TTtggacaaacagctgttACATAGCATTACCCAAGGGgtgatgcattttatgaaagtg a" /listShort="spoIVCA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2253927) /Source="Nicolas_upshifts" /id="U2008" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1098 /SigmaFactorBS="gaaacgtttaataacactatagtttaatttaaaatctcCTCA TTtggacaaacagctgttACATAGCATTACCCAAGGGgtgatgcattttatgaaagtg a" /listShort="spoIVCA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2253929..2254230) /Source="Nicolas_S_feature" /locus_tag="new_2655000_2655301_c" /HighExp="dia5, Diami, S8, S7, dia15, C30, G135, S6, G180, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.974" /TUlongSig="NA" /TUlongPSig="NA" /label="S972" promotor_-35 complement(2253944..2253949) /Source="Nicolas_upshift_promotors" /id="U2008" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1098 /SigmaFactorBS="gaaacgtttaataacactatagtttaatttaaaatctcCTCA TTtggacaaacagctgttACATAGCATTACCCAAGGGgtgatgcattttatgaaagtg a" /listShort="spoIVCA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2254251..2254670) /gene="arsC" /locus_tag="BSU_25780" /old_locus_tag="BSU25780" /EC_number="1.20.4.4" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11698660, 16192272, 16905151, 8760915, 8969508, 9537360, 17303556, 21258851, 21904062, 23813734" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11698660, 16192272, 16905151, 8760915, 8969508, 9537360, 17303556, 21258851, 21904062, 23813734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thioredoxin-coupled arsenate reductase; skin element" /protein_id="NP_390455.1" /db_xref="EnsemblGenomes-Gn:BSU25780" /db_xref="EnsemblGenomes-Tr:CAB14519" /db_xref="GOA:P45947" /db_xref="InterPro:IPR014064" /db_xref="InterPro:IPR023485" /db_xref="InterPro:IPR036196" /db_xref="PDB:1JL3" /db_xref="PDB:1Z2D" /db_xref="PDB:1Z2E" /db_xref="PDB:2IPA" /db_xref="SubtiList:BG11304" /db_xref="UniProtKB/Swiss-Prot:P45947" /translation="MENKIIYFLCTGNSCRSQMAEGWAKQYLGDEWKVYSAGIEAHGL NPNAVKAMKEVGIDISNQTSDIIDSDILNNADLVVTLCGDAADKCPMTPPHVKREHWG FDDPARAQGTEEEKWAFFQRVRDEIGNRLKEFAETGK*" /label="arsC CDS" gene complement(2254251..2254670) /gene="arsC" /locus_tag="BSU_25780" /old_locus_tag="BSU25780" /label="arsC gene" downshifts complement(2254275) /Source="Nicolas_upshifts" /id="D1338" /incds=0 /nref=106 /ntot=239 /MaxReadThrough="3.85143" /MaxDrop="6.98965" /score="17.1730317" /energy="-8.6" /TU="U2009" /idTUdmin="U2009" /TUdmin="-1823" /isTUend="FALSE" /label="downshifts" CDS complement(2254682..>2254810) /gene="arsB" /locus_tag="Delta6_pseudo_BSU_25790" /old_locus_tag="BSU25790" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9537360, 15849754, 16850406, 16905151; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arsenite efflux transporter; skin element" /protein_id="NP_390456.2" /db_xref="EnsemblGenomes-Gn:BSU25790" /db_xref="EnsemblGenomes-Tr:CAB14520" /db_xref="GOA:P45946" /db_xref="InterPro:IPR002657" /db_xref="InterPro:IPR004706" /db_xref="SubtiList:BG11303" /db_xref="UniProtKB/Swiss-Prot:P45946" /NCBI_locus_tag="A8O17_RS20905" /modified_by="User" /translation="YRIHSGAAFAAVIGPLVEVPVMIALVKVALWFQRKYFGSHSM*" /label="Delta6_pseudo_BSU_25790" gene complement(2254682..>2254810) /gene="arsB" /locus_tag="Delta6_pseudo_BSU_25790" /old_locus_tag="BSU25790" /NCBI_locus_tag="A8O17_RS20905" /modified_by="User" /label="Delta6_pseudo_BSU_25790" SCAR join(2254806,2254813) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="TFC7A" N_region 2254807..2254812 /note="EcoRV side (GATATC)" /created_by="User" /modified_by="User" /label="TFC7A" CDS <2254808..2255194 /NCBI_locus_tag="A8O17_RS12485" /NCBI_old_locus_tag="A8O17_12485" /inference="COORDINATES: similar to AA sequence:RefSeq:NP_390515.1" /note="incomplete; partial in the middle of a contig; missing N-terminus; Derived by automated computational analysis using gene prediction method: Protein Homology." /pseudo /codon_start=1 /transl_table=11 /product="ImmA/IrrE family metallo-endopeptidase" /locus_tag="Delta6_pseudo_BSU_26380" /modified_by="User" /translation="ISSFALKHSGIYNICLDSRKSRTEQWYDFAHEFCHIYRHEGDKK TMPATWTDYLDWQSNYFTYHFCIPTCMLRNINLPYIQSHAIENVAWLFKVSPSFAKKR LSIYYRKLTQHLFSQTVTGNLCPPFL*" /label="Delta6_pseudo_BSU_26380" gene <2254808..2255194 /NCBI_locus_tag="A8O17_RS12485" /NCBI_old_locus_tag="A8O17_12485" /pseudo /locus_tag="Delta6_pseudo_BSU_26380" /modified_by="User" /label="Delta6_pseudo_BSU_26380" misc_feature complement(2255161..2255179) /Source="Nicolas_upshift_promotors" /id="U2034" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.888111888111888" /psig="0.888111888111888" /xcortree=1184 /SigmaFactorBS="acgtctttttttgtttttttcaatgcgcgcaaatgcatgagg atttcattattcattacaaaaaggggggGCATAAATTTCCCGTAACAgtttgactaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 2255176..2255592 /gene="sigKc" /locus_tag="BSU_26390" /old_locus_tag="BSU26390" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2163341, 7704261, 8969508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2163341, 7704261, 8969508; Product type f: factor" /pseudo /codon_start=1 /transl_table=11 /product="RNA polymerase sporulation-specific sigma-K factor precursor (Sigma-27) (C-terminal fragment)" /db_xref="GOA:P12254" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="PSEUDO:CAB14580.1" /db_xref="SubtiList:BG10919" /db_xref="UniProtKB/Swiss-Prot:P12254" /translation="MPPLFVMNNEILMHLRALKKTKKDVSLHDPIGQDKEGNEISLID VLKSENEDVIDTIQLNMELEKVKQYIDILDDREKEVIVGRFGLDLKKEKTQREIAKEL GISRSYVSRIEKRALMKMFHEFYRAEKEKRKKAKGK*" /label="sigKc CDS" gene 2255176..2255592 /gene="sigKc" /locus_tag="BSU_26390" /old_locus_tag="BSU26390" /pseudo /label="sigKc gene" misc_feature 2255181..2255195 /Source="Nicolas_upshift_promotors" /id="U2035" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.647352647352647" /psig="0.217782217782218" /xcortree=1060 /SigmaFactorBS="tcaacatttatttagtcaaactgttacgggaaatttatgccC CCCCTTTTTGTAATgaataatgaaatcctcatgcatttgcgcgcattgaaaaaaacaa a" /listShort="spoIIIC, S984" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2255189) /Source="Nicolas_upshifts" /id="U2034" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.888111888111888" /psig="0.888111888111888" /xcortree=1184 /SigmaFactorBS="acgtctttttttgtttttttcaatgcgcgcaaatgcatgagg atttcattattcattacaaaaaggggggGCATAAATTTCCCGTAACAgtttgactaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts 2255200 /Source="Nicolas_upshifts" /id="U2035" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.647352647352647" /psig="0.217782217782218" /xcortree=1060 /SigmaFactorBS="tcaacatttatttagtcaaactgttacgggaaatttatgccC CCCCTTTTTGTAATgaataatgaaatcctcatgcatttgcgcgcattgaaaaaaacaa a" /listShort="spoIIIC, S984" /GFF_Attribute="listLong" /label="upshifts" downshifts 2255576 /Source="Nicolas_upshifts" /id="D1357" /incds=0 /nref=50 /ntot=108 /MaxReadThrough="3.60274" /MaxDrop="5.60264" /score="-0.848064104" /energy="-4.5" /TU="U2035" /idTUdmin="U2033" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS 2255592..2255708 /locus_tag="BSU_26399" /old_locus_tag="BSU26399" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513982.1" /translation="MQKKPDLILRLSLFERVMKIIFFIADKLSEKDRQDRNK*" /label="hypothetical protein CDS" gene 2255592..2255708 /locus_tag="BSU_26399" /old_locus_tag="BSU26399" /label="gene" S_feature 2255621..2256955 /Source="Nicolas_S_feature" /locus_tag="new_2701783_2703117" /HighExp="S8, S6, S7, S5, S4, BT, B36, dia15, C30, H2O2" /AntisenseName="psiE" /AntisenseCor="0.376363934894826" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="0.117191" /TUshortSig="Sig-" /TUshortPSig="0.218" /TUlongSig="NA" /TUlongPSig="NA" /label="S984" downshifts complement(2255739) /Source="Nicolas_upshifts" /id="D1358" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="3.25265" /MaxDrop="3.18978" /score="3.17084908" /energy="-14.7" /TU="NA" /idTUdmin="U2036" /TUdmin=66 /isTUend="FALSE" /label="downshifts" CDS complement(2255817..2255981) /gene="yrkS" /locus_tag="BSU_26400" /old_locus_tag="BSU26400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390517.1" /db_xref="EnsemblGenomes-Gn:BSU26400" /db_xref="EnsemblGenomes-Tr:CAB14581" /db_xref="SubtiList:BG11785" /db_xref="UniProtKB/Swiss-Prot:P54446" /translation="MKVIIIEGLQTDKCMNDCYHYLIKLYRQEIQGDSNISWNKRSRD RASTARSRPV*" /label="yrkS CDS" gene complement(2255817..2255981) /gene="yrkS" /locus_tag="BSU_26400" /old_locus_tag="BSU26400" /label="yrkS gene" promotor_-10 complement(2255911..2255930) /Source="Nicolas_upshift_promotors" /id="U2036" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.824175824175824" /psig="0.975024975024975" /xcortree=1403 /SigmaFactorBS="aggggtgatgtattttatgaaggtaataatcatcgagggact gcaAACTGACAaatgcatgaacgatTGCTATCATTATTTAATAAAactttataggcag g" /listShort="yrkS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2255937) /Source="Nicolas_upshifts" /id="U2036" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.824175824175824" /psig="0.975024975024975" /xcortree=1403 /SigmaFactorBS="aggggtgatgtattttatgaaggtaataatcatcgagggact gcaAACTGACAaatgcatgaacgatTGCTATCATTATTTAATAAAactttataggcag g" /listShort="yrkS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2255945..2255952) /Source="Nicolas_upshift_promotors" /id="U2036" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.824175824175824" /psig="0.975024975024975" /xcortree=1403 /SigmaFactorBS="aggggtgatgtattttatgaaggtaataatcatcgagggact gcaAACTGACAaatgcatgaacgatTGCTATCATTATTTAATAAAactttataggcag g" /listShort="yrkS" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2256115) /Source="Nicolas_upshifts" /id="D1359" /incds=0 /nref=79 /ntot=219 /MaxReadThrough="1.20909" /MaxDrop="4.40328" /score="39.3560776" /energy="-10.6" /TU="NA" /idTUdmin="U2036" /TUdmin="-310" /isTUend="FALSE" /label="downshifts" CDS complement(2256526..2256942) /gene="psiE" /locus_tag="BSU_26410" /old_locus_tag="BSU26410" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12897016, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="phosphate starvation inducible protein" /protein_id="NP_390518.2" /db_xref="EnsemblGenomes-Gn:BSU26410" /db_xref="EnsemblGenomes-Tr:CAB14582" /db_xref="GOA:P54445" /db_xref="InterPro:IPR009315" /db_xref="InterPro:IPR020948" /db_xref="SubtiList:BG11784" /db_xref="UniProtKB/Swiss-Prot:P54445" /translation="MRFSNKFKKVPYLLQALLNVCLFFLALALSALLISETWYIVLFV YKSLFNKVDSYYEMLGELLIFFMYFEFIALIIKYFKSDFHFPLRYFIYIGITAVIRLI IIDHDQAISTFWWAMAILAMICGFFIANRRNSVVEH*" /label="psiE CDS" gene complement(2256526..2256942) /gene="psiE" /locus_tag="BSU_26410" /old_locus_tag="BSU26410" /label="psiE gene" CDS complement(2256988..2258286) /gene="yrkQ" /locus_tag="BSU_26420" /old_locus_tag="BSU26420" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YrkP]" /protein_id="NP_390519.1" /db_xref="EnsemblGenomes-Gn:BSU26420" /db_xref="EnsemblGenomes-Tr:CAB14583" /db_xref="GOA:P54444" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11783" /db_xref="UniProtKB/Swiss-Prot:P54444" /translation="MAHLKFTLTKKLALLIMVAAIVSGVIFLTLQKITDDLIEGYLSS EEYYHEESARYIQKFSKYVSENELSTSDRKAFGEWVKKENYINLTIFKDQELQYDSIY SESDYGKEKLTQYAQNHSHPVKFSDGEGRVIIDGFYSSRYYDLAFALDLLGATLIFLI IVLFGIRQSLRYLKTIHQEIHILEGGELDYEMTIKGHDELAMIAKSIEDLRKAFLDKL KAIEELQAESRSLVTEMSHDMRTPLTSLIMNLEFAKKEGGEAGASKDRYVANAYGKAL QLKSLSDNLFAYFLLNKEYEADLETVAVKEVIYDLISDQIAILHQEHFRVHISGELPE TYINVNLEELGRVFDNVMSNLLKYADPEEKISITFVSDQEIFEIHVSNTIKLADITPE SNGLGERSIARMMSRMQGQFHSIQKNSKYYIVLRFWNTKM*" /label="yrkQ CDS" gene complement(2256988..2258286) /gene="yrkQ" /locus_tag="BSU_26420" /old_locus_tag="BSU26420" /label="yrkQ gene" CDS complement(2258273..2258968) /gene="yrkP" /locus_tag="BSU_26430" /old_locus_tag="BSU26430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 18175906" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18175906; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YrkQ]" /protein_id="NP_390520.1" /db_xref="EnsemblGenomes-Gn:BSU26430" /db_xref="EnsemblGenomes-Tr:CAB14584" /db_xref="GOA:P54443" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11782" /db_xref="UniProtKB/Swiss-Prot:P54443" /translation="MAYRILVVEDDEDIGDLLEESLTRAGYEVLRAKDGKRALQLVND SLDLVILDIMMPGISGIETCQHIRKSSNVPILFLTARSSTLDKTEGLLAGGDDYMTKP FSEEELHARVIAQLRRYTIYQEKKEQEETFLIGGKLRVSEEFNEVWKEEKQIKLSDLE YRILKLLMNKRNKIFSAQNIYESVWGQPYFYCSNNTVMVHIRKLRSKIEDDPARPVYI KTEWGRGYRFGAS*" /label="yrkP CDS" gene complement(2258273..2258968) /gene="yrkP" /locus_tag="BSU_26430" /old_locus_tag="BSU26430" /label="yrkP gene" misc_feature complement(2259034..2259051) /Source="Nicolas_upshift_promotors" /id="U2037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.270729270729271" /psig="0.737262737262737" /xcortree=673 /SigmaFactorBS="acaaatttgtggcgagcatcagctttcataaattgttaagat ttacgtagtaTCTTATAACGTACTTATTactatgaacgatatatagtaaggacacacg a" /listShort="yrkP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2259043) /Source="Nicolas_upshifts" /id="U2037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.270729270729271" /psig="0.737262737262737" /xcortree=673 /SigmaFactorBS="acaaatttgtggcgagcatcagctttcataaattgttaagat ttacgtagtaTCTTATAACGTACTTATTactatgaacgatatatagtaaggacacacg a" /listShort="yrkP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2259129..2259135 /Source="Nicolas_upshift_promotors" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2259142..2259160 /Source="Nicolas_upshift_promotors" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2259157 /Source="Nicolas_upshifts" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2259236..2260453 /gene="yrkO" /locus_tag="BSU_26440" /old_locus_tag="BSU26440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21737930; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390521.1" /db_xref="EnsemblGenomes-Gn:BSU26440" /db_xref="EnsemblGenomes-Tr:CAB14585" /db_xref="GOA:P54442" /db_xref="InterPro:IPR007349" /db_xref="SubtiList:BG11781" /db_xref="UniProtKB/Swiss-Prot:P54442" /translation="MIVQKEGRGQPVSLRERVHFLDIVRGFALLGIIIVNYFLIVDSV KGFEMASDDVLHKLVSWFAEGKFVTLFSFLFGVGFMIFMDRAAQKVESPNKLFARRLS ILLGFGILHITFVWVGDILAFYAVSGFLLLAFYKRTAKTVLRWIIALIVFQFLTPVFT MLYNVINTAGSKNPNFSEFTLFSHSSLTYMESISTRWTDMVTMAAGSFSMIYSMFLMF LLGVYFVKMEFFKDMEAKKPIWKRIWIISTIAFLITQSSILLDMFNLSENMLWKDISS VLGQNGGLTGSMFYMSTFAMLFLYLPQLRGPMMIFTKVGRMSLTCYLLHSIIGTVLFL RYGFGLADHIQSAGTFMFSLAVYFVLMSFSTLWLKRFRYGPMELVWRKLTYGKVNGSP KATPLHSEKSIQK*" /label="yrkO CDS" gene 2259236..2260453 /gene="yrkO" /locus_tag="BSU_26440" /old_locus_tag="BSU26440" /label="yrkO gene" promotor_-35 2259695..2259702 /Source="Nicolas_upshift_promotors" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2259717..2259736 /Source="Nicolas_upshift_promotors" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2259733 /Source="Nicolas_upshifts" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2260372..2260620 /locus_tag="BSU_26449" /old_locus_tag="BSU26449" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513983.1" /translation="MAQADVRQSKRESQSNSAAFGKIYSEITPLHRLHDFKLVLLNEA GIKRTDLIYGLVIFISFRLLWANKSTRVYSMCIAHDRI*" /label="hypothetical protein CDS" gene 2260372..2260620 /locus_tag="BSU_26449" /old_locus_tag="BSU26449" /label="gene" S_feature complement(2260549..2261596) /Source="Nicolas_S_feature" /locus_tag="new_2706711_2707758_c" /HighExp="Diami, C30, dia15, dia5, Lbstat, S8, C90, G180, H2O2, G135" /AntisenseName="yrkN" /AntisenseCor="0.40539464433869998" /AntisenseRegPval="-11.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S985" CDS 2260965..2261522 /gene="yrkN" /locus_tag="BSU_26450" /old_locus_tag="BSU26450" /EC_number="2.3.-.-" /function="16.8: Protect" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18175906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390522.1" /db_xref="EnsemblGenomes-Gn:BSU26450" /db_xref="EnsemblGenomes-Tr:CAB14586" /db_xref="GOA:P54441" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11780" /db_xref="UniProtKB/Swiss-Prot:P54441" /translation="MKTKNEPKVILELAKESDLPEFQKKLQEAFAIAVIETFGDCEDG PIPSDNDVQESFNAPGAVVYHILQDGKNVGGAVVRINSQTNHNSLDLFYVSPEYHSQG IGLSAWKAIEAQYPDTVLWETVTPYFEKRNINFYVNKCGFHIVEFYNEHHSNPHMHRN GREDDKPLLNDDDFFRFVKIMKKKD*" /label="yrkN CDS" gene 2260965..2261522 /gene="yrkN" /locus_tag="BSU_26450" /old_locus_tag="BSU26450" /label="yrkN gene" S_feature 2261523..2261645 /Source="Nicolas_S_feature" /locus_tag="new_2707685_2707807" /HighExp="S8, Sw, C30, S7, BC, C90, Lbstat, Mal, LoTm, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S986" S_feature complement(2261598..2262012) /Source="Nicolas_S_feature" /locus_tag="new_2707760_2708174_c" /HighExp="M0t90, M40t90, Lbstat, dia5, LPhT, dia15, M9-stat, Lbtran, C90, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S987" downshifts complement(2261641) /Source="Nicolas_upshifts" /id="D1360" /incds=0 /nref=81 /ntot=255 /MaxReadThrough="5.45539" /MaxDrop="5.6563" /score="-3.35079978" /energy="-23.7" /TU="U2041,U2042,U2044,U2045" /idTUdmin="U2042" /TUdmin="-182" /isTUend="FALSE" /label="downshifts" CDS complement(2262013..2262537) /gene="yrkL" /locus_tag="BSU_26470" /old_locus_tag="BSU26470" /EC_number="1.6.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11053405; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)H oxidoreductase" /protein_id="NP_390524.2" /db_xref="EnsemblGenomes-Gn:BSU26470" /db_xref="EnsemblGenomes-Tr:CAB14588" /db_xref="GOA:P54439" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG11778" /db_xref="UniProtKB/Swiss-Prot:P54439" /translation="MKTLVIVIHPNLETSVVNKTWMNRLKQEKDITVHDLYGEYPNFI IDVEKEQQLLLDHERIVFQFPMYWYSSPALLKQWEDDVLTHGWAYGTGGTKLHGKELL LAISLGAQESDYQAGGEYNITISELIRPFQVTANYIGMRFLPAFTQYGTLHLSKEDVK NSAERLVDYLKAEH*" /label="yrkL CDS" gene complement(2262013..2262537) /gene="yrkL" /locus_tag="BSU_26470" /old_locus_tag="BSU26470" /label="yrkL gene" promotor_-35 2262385..2262392 /Source="Nicolas_upshift_promotors" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2262403..2262422 /Source="Nicolas_upshift_promotors" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2262417 /Source="Nicolas_upshifts" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2262538..2262625) /Source="Nicolas_S_feature" /locus_tag="new_2708700_2708787_c" /HighExp="dia5, Etha, dia15, M9-stat, M0t90, Lbtran, Diami, C90, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S988" promotor_-10 complement(2262620..2262639) /Source="Nicolas_upshift_promotors" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2262625) /Source="Nicolas_upshifts" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2262627..>2262763) /Source="Nicolas_S_feature" /locus_tag="new_2708789_2708942_c" /HighExp="M0t90, M9-stat, Lbstat, M40t90, T1.30H, C90, Lbtran, T0.30H, dia15, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S989" promotor_-35 complement(2262654..2262661) /Source="Nicolas_upshift_promotors" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-35" SCAR join(2262763,2262770) /created_by="User" /note="deletion occured in betwen marked nucleotides " /modified_by="User" /label="IIG_Bs12" N_region 2262764..2262769 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs12" CDS complement(2262822..2263352) /gene="sigZ" /locus_tag="BSU_26840" /old_locus_tag="BSU26840" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11700344, 15019740, 17675383" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11700344, 15019740, 17675383; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor (sigma-Z)" /protein_id="NP_390561.1" /db_xref="EnsemblGenomes-Gn:BSU26840" /db_xref="EnsemblGenomes-Tr:CAB14625" /db_xref="GOA:O05409" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014304" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11976" /db_xref="UniProtKB/Swiss-Prot:O05409" /translation="MNIEDLWDQFHQPLKTYISHRVNDQSIVDDLLQIVFMKIQVHLP NLIDEQKIDSWIYRITRNTIIDFYRTKKTSEILPDVLHFNDSAEEENFTKEATVCIRS TIKRLPEKYREALELTDFQGLSQKELSEKLGISYSGAKSRVQRGRGKLKQLLEGCCHI EADRYGNIVDFRILKE*" /label="sigZ CDS" gene complement(2262822..2263352) /gene="sigZ" /locus_tag="BSU_26840" /old_locus_tag="BSU26840" /label="sigZ gene" promotor_-10 complement(2263398..2263417) /Source="Nicolas_upshift_promotors" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2263421) /Source="Nicolas_upshifts" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2263431..2263438) /Source="Nicolas_upshift_promotors" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2263487..2264467 /gene="yrpG" /locus_tag="BSU_26850" /old_locus_tag="BSU26850" /EC_number="1.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23990306, 25326299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldo-keto reductase" /protein_id="NP_390562.2" /db_xref="EnsemblGenomes-Gn:BSU26850" /db_xref="EnsemblGenomes-Tr:CAB14626" /db_xref="GOA:O05408" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG12309" /db_xref="UniProtKB/Swiss-Prot:O05408" /translation="MEYTYLGRTGLRVSRLCLGTMNFGVDTDEKTAFRIMDEALDNGI QFFDTANIYGWGKNAGLTESIIGKWFAQGGQRREKVVLATKVYEPISDPNDGPNDMRG LSLYKIRRHLEGSLKRLQTDHIELYQMHHIDRRTPWDEIWEAFETQVRSGKVDYIGSS NFAGWHLVKAQAEAEKRRFMGLVTEQHKYSLLERTAEMEVLPAARDLGLGVVAWSPLA GGLLGGKALKSNAGTRTAKRADLIEKHRLQLEKFSDLCKELGEKEANVALAWVLANPV LTAPIIGPRTVEQLRDTIKAVEISLDKEILRMLNDIFPGPGGETPEAYAW*" /label="yrpG CDS" gene 2263487..2264467 /gene="yrpG" /locus_tag="BSU_26850" /old_locus_tag="BSU26850" /label="yrpG gene" CDS complement(2264741..2266057) /gene="yraO" /locus_tag="BSU_26860" /old_locus_tag="BSU26860" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11053381, 11566984, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative citrate transporter" /protein_id="NP_390563.1" /db_xref="EnsemblGenomes-Gn:BSU26860" /db_xref="EnsemblGenomes-Tr:CAB14627" /db_xref="GOA:O05407" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG12279" /db_xref="UniProtKB/Swiss-Prot:O05407" /translation="MLTILGFSMVTVFTILIMTKKVSPIVALTITPIVFALIGGFGKG IGDMILEGIQTVASSAALLLFAILFFGILIDAGLFDPLIEKILSIVKGDPVKIAIGSA VLAMLIALDGDGTTTYMITVSAMLPLYKRIGMNPMVMATLAMLSLSIVSGMTPWGGPA TRAISVLGLDPSDFFVPLLPTMLGGIACVIFLAFLMGRKERNRIGIVQLEPRHITKDS SQSYMAATLESEQLKRPRLIYLNLFLVISIMVFIVLGTKHPSVLFLIGFVLALTINYP NVKMQKERIAEHSGNAITVVLLVFSAGVFAGILSGTKMVDAIAGSLISIIPSSMGGFF PVIVALTSIPFTFVLSNDAYYFGMVPIFAEAASAYGIEPVEIARASIMGQPVHLMSPL VASTVLLVSMLKMDLGSFQRFAVKWAVITSLVITLLAIITGAITIL*" /label="yraO CDS" gene complement(2264741..2266057) /gene="yraO" /locus_tag="BSU_26860" /old_locus_tag="BSU26860" /label="yraO gene" S_feature complement(2266058..2266171) /Source="Nicolas_S_feature" /locus_tag="new_2745480_2745593_c" /HighExp="Lbtran, M40t90, Lbstat, HiTm, Mal, Gly, M0t90, S1, T1.0H, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1012" CDS complement(2266172..2267041) /gene="yraN" /locus_tag="BSU_26870" /old_locus_tag="BSU26870" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20011599; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (probes citrate or citrate-related metabolite)" /protein_id="NP_390564.1" /db_xref="EnsemblGenomes-Gn:BSU26870" /db_xref="EnsemblGenomes-Tr:CAB14628" /db_xref="GOA:O07906" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12278" /db_xref="UniProtKB/Swiss-Prot:O07906" /translation="MDEKDWILLKILHEEQSVTKTAERLFTSQPSITYRLKKIEEIFG IELFTKRHKGITFTAEGEHLVAYARRMLQELQDTKDHISNLSKEVQGHLRLGVSSNFA QYKLPKLLREFSTMYPNVQYSVQTGWSTDVMKLLDAGIVQVGILRGSHRWKGVEERLT REKLHIISKKPITIEQLPFLPFIKYKTDASLKTIIEDWMHTNLKQAPIIAMEVDRQET CKEMVKHGLGYSIAPEICLQESDHLYTMELYNAKGKPLMRDTWLMYDQKSLGIKLVKA FIDFLKGEQMVTI*" /label="yraN CDS" gene complement(2266172..2267041) /gene="yraN" /locus_tag="BSU_26870" /old_locus_tag="BSU26870" /label="yraN gene" promotor_-10 complement(2267064..2267083) /Source="Nicolas_upshift_promotors" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2267081) /Source="Nicolas_upshifts" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2267098..2267103) /Source="Nicolas_upshift_promotors" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2267148..2267149) /Source="Nicolas_upshift_promotors" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2267156) /Source="Nicolas_upshifts" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2267186..2267187) /Source="Nicolas_upshift_promotors" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2267186..2268289 /gene="prpF" /locus_tag="BSU_26880" /old_locus_tag="BSU26880" /EC_number="5.3.3.7" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11294638, 12473114, 14702315, 17567742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aconitate isomerase" /protein_id="NP_390565.2" /db_xref="EnsemblGenomes-Gn:BSU26880" /db_xref="EnsemblGenomes-Tr:CAB14629" /db_xref="GOA:O07931" /db_xref="InterPro:IPR007400" /db_xref="SubtiList:BG12277" /db_xref="UniProtKB/Swiss-Prot:O07931" /translation="MVKTNVTIMRGGTSKGVFFHESAMPNNKNEWEPFLLDVMGSPDK RQIDGLGGGNSLTSKVAIIKKAYTSDIDVHYTFGQVSISEEKVDFKGNCGNISAAVGP FAIEEGLVKAKEPMTAVRILNTNTNKMIIAEVEVEDGQVKYDGDVTISGVPGSGSPIY LNFHDAAGSVTGHLLPTGNSSEFLDTSQGQIEVSIIDYANPLVFVEASSIGLDGTELA EEFTDLQLAQFEELRSIAAEKCGFASRFSATKLSPAVPKLAIVAKPEKYKDSTGAWHS SVEMDLHIRMMSMQKPHQALAVTGAICTTRALSVEGAIPARIAKNHSTKVRLAHSSGI IETMVEPTGIKIVRTARRIMDGTVYTHGDYQMM*" /label="prpF CDS" gene 2267186..2268289 /gene="prpF" /locus_tag="BSU_26880" /old_locus_tag="BSU26880" /label="prpF gene" misc_feature 2268179..2268198 /Source="Nicolas_upshift_promotors" /id="U2070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.736263736263736" /psig="0.984015984015984" /xcortree=3092 /SigmaFactorBS="atccctgcaagaatagcaaaaaaccactctacaaaggttcgg ctagctcattctTCTGGTATTATTGAAACAATggtggagcccactggtataaagatcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2268185 /Source="Nicolas_upshifts" /id="U2070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.736263736263736" /psig="0.984015984015984" /xcortree=3092 /SigmaFactorBS="atccctgcaagaatagcaaaaaaccactctacaaaggttcgg ctagctcattctTCTGGTATTATTGAAACAATggtggagcccactggtataaagatcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2268536) /Source="Nicolas_upshifts" /id="D1374" /incds=0 /nref=123 /ntot=254 /MaxReadThrough="2.33762" /MaxDrop="7.47213" /score="6.31571576" /energy="-8.7" /TU="U2071" /idTUdmin="U2071" /TUdmin="-33" /isTUend="FALSE" /label="downshifts" CDS complement(2268562..2269395) /gene="csn" /locus_tag="BSU_26890" /old_locus_tag="BSU26890" /EC_number="3.2.1.132" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11065371, 11320136, 1664582, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11065371, 11320136, 1664582, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chitosanase" /protein_id="NP_390566.1" /db_xref="EnsemblGenomes-Gn:BSU26890" /db_xref="EnsemblGenomes-Tr:CAB14630" /db_xref="GOA:O07921" /db_xref="InterPro:IPR000400" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG11923" /db_xref="UniProtKB/Swiss-Prot:O07921" /translation="MKISMQKADFWKKAAISLLVFTMFFTLMMSETVFAAGLNKDQKR RAEQLTSIFENGTTEIQYGYVERLDDGRGYTCGRAGFTTATGDALEVVEVYTKAVPNN KLKKYLPELRRLAKEESDDTSNLKGFASAWKSLANDKEFRAAQDKVNDHLYYQPAMKR SDNAGLKTALARAVMYDTVIQHGDGDDPDSFYALIKRTNKKAGGSPKDGIDEKKWLNK FLDVRYDDLMNPANHDTRDEWRESVARVDVLRSIAKENNYNLNGPIHVRSNEYGNFVI K*" /label="csn CDS" gene complement(2268562..2269395) /gene="csn" /locus_tag="BSU_26890" /old_locus_tag="BSU26890" /label="csn gene" misc_feature complement(2269425..2269444) /Source="Nicolas_upshift_promotors" /id="U2071" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.84015984015984" /psig="0.992007992007992" /xcortree=504 /SigmaFactorBS="agattcaaaatattgacaaattgatgtattttcaacaatagg gcagtttcTTCATGTATACTGAGTCTGTatttacaatatttagaaaggggaagtgaaa t" /listShort="csn" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2269434) /Source="Nicolas_upshifts" /id="U2071" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.84015984015984" /psig="0.992007992007992" /xcortree=504 /SigmaFactorBS="agattcaaaatattgacaaattgatgtattttcaacaatagg gcagtttcTTCATGTATACTGAGTCTGTatttacaatatttagaaaggggaagtgaaa t" /listShort="csn" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2269600..2269604 /Source="Nicolas_upshift_promotors" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2269615..2269837 /Source="Nicolas_S_feature" /locus_tag="new_2749037_2749259" /HighExp="Lbstat, M9-stat, B60, M0t90, M40t90, T1.30H, T2.0H, T3.0H, T2.30H, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.97565800000000003" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1013" upshifts 2269615 /Source="Nicolas_upshifts" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2269619..2269638 /Source="Nicolas_upshift_promotors" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2269838..2270101 /gene="yraL" /locus_tag="BSU_26900" /old_locus_tag="BSU26900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390567.1" /db_xref="EnsemblGenomes-Gn:BSU26900" /db_xref="EnsemblGenomes-Tr:CAB14631" /db_xref="GOA:O07917" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG12276" /db_xref="UniProtKB/Swiss-Prot:O07917" /translation="MAYVKATAILPEKLISEIQKYVQGKTIYIPKPESSHQKWGACSG TRKLIDDRNASIKKAFKNGKTIHQLSDEYHLSIETIKKIVYSK*" /label="yraL CDS" gene 2269838..2270101 /gene="yraL" /locus_tag="BSU_26900" /old_locus_tag="BSU26900" /label="yraL gene" downshifts 2270089 /Source="Nicolas_upshifts" /id="D1375" /incds=0 /nref=71 /ntot=223 /MaxReadThrough="1.7419" /MaxDrop="4.94534" /score="-1.04752822" /energy="-9.9" /TU="NA" /idTUdmin="U2072" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS 2270238..2271053 /gene="yraK" /locus_tag="BSU_26910" /old_locus_tag="BSU26910" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390568.2" /db_xref="EnsemblGenomes-Gn:BSU26910" /db_xref="EnsemblGenomes-Tr:CAB14632" /db_xref="GOA:O07937" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12275" /db_xref="UniProtKB/Swiss-Prot:O07937" /translation="MTINNGTLQVPGANIHYQVRGSGPIILLVHGGGGDADKFHHVAN HLANWYTVVTYDRRGHSRSNLANQIEGYRVETHSDDAHRLLAKITNKPAYVFGSSSGA VIGLDLCIRHPEQVHVMIPHEPILLQLLHGNELKQAEQFMEDLKKNHRSEVIKLMSRL ETDEQSKAVLTKRLLGNSTYFTEYEIQGILSYTLDFEALKTVFTSSPMKILPAGGSAS RELFPYRCANALAEQLETEWVEFPGNHTGYTMYHKEFSERLHDMLEKEKKHTC*" /label="yraK CDS" gene 2270238..2271053 /gene="yraK" /locus_tag="BSU_26910" /old_locus_tag="BSU26910" /label="yraK gene" S_feature complement(2271388..2271460) /Source="Nicolas_S_feature" /locus_tag="new_2750810_2750882_c" /HighExp="BC, Lbstat, Sw, M40t90, M0t90, S2, BI, BT, S3, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1014" downshifts complement(2271431) /Source="Nicolas_upshifts" /id="D1376" /incds=0 /nref=44 /ntot=205 /MaxReadThrough="1.43644" /MaxDrop="4.78753" /score="-0.984762906" /energy="-12.6" /TU="NA" /idTUdmin="U2073" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2271461..2271817) /gene="yraJ" /locus_tag="BSU_26920" /old_locus_tag="BSU26920" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390569.2" /db_xref="EnsemblGenomes-Gn:BSU26920" /db_xref="EnsemblGenomes-Tr:CAB14633" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12274" /db_xref="UniProtKB/Swiss-Prot:O07934" /translation="MTKLKMLSMLTVMIASLFIFSSQALAVQYFTVSTSSGAPVNMRS GPGTNYPIMLSIPSGSRVPYYCYAYGTTVTGKYGTSNIWDQIQWKDSRGVVNIGYVSD TYVYTGSDGPVGYKCN*" /label="yraJ CDS" gene complement(2271461..2271817) /gene="yraJ" /locus_tag="BSU_26920" /old_locus_tag="BSU26920" /label="yraJ gene" CDS complement(2271870..2272229) /gene="yraI" /locus_tag="BSU_26930" /old_locus_tag="BSU26930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390570.2" /db_xref="EnsemblGenomes-Gn:BSU26930" /db_xref="EnsemblGenomes-Tr:CAB14634" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12273" /db_xref="UniProtKB/Swiss-Prot:O07909" /translation="MNKLKRLSMLTVMIASVFIFSSHALAAQYYTVSTSSGAPVNMRS GPGTSWGIVTTIPSGTRIPIYCYKTGTTVTGKYGTSNIWNYTERTLASGEIVPGFVSD TYMYTGSDGPVVPKCSW*" /label="yraI CDS" gene complement(2271870..2272229) /gene="yraI" /locus_tag="BSU_26930" /old_locus_tag="BSU26930" /label="yraI gene" misc_feature complement(2272322..2272341) /Source="Nicolas_upshift_promotors" /id="U2073" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.487512487512487" /psig="0.99100899100899" /xcortree=492 /SigmaFactorBS="tccttaattgtcgaaaacataggaataattccacttttgaaa gatctagttTATGGTACATTGATAAATATatgggaggggagggggcatggtatctgaa a" /listShort="yraI, yraJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2272332) /Source="Nicolas_upshifts" /id="U2073" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.487512487512487" /psig="0.99100899100899" /xcortree=492 /SigmaFactorBS="tccttaattgtcgaaaacataggaataattccacttttgaaa gatctagttTATGGTACATTGATAAATATatgggaggggagggggcatggtatctgaa a" /listShort="yraI, yraJ" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2272501..2272602) /locus_tag="BSU_26935" /old_locus_tag="BSU26935" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513987.1" /translation="MIGEKGGVSMNREEAWIQGSSTLIELIGGNEAA*" /label="hypothetical protein CDS" gene complement(2272501..2272602) /locus_tag="BSU_26935" /old_locus_tag="BSU26935" /label="gene" S_feature complement(2272642..2272744) /Source="Nicolas_S_feature" /locus_tag="new_2752064_2752166_c" /HighExp="M40t90, LBGstat, M40t45, M0t90, Lbstat, Lbtran, LBGtran, LPhT, ferm, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.575" /TUlongSig="NA" /TUlongPSig="NA" /label="S1015" downshifts complement(2272684) /Source="Nicolas_upshifts" /id="D1377" /incds=0 /nref=19 /ntot=188 /MaxReadThrough="2.12056" /MaxDrop="4.09264" /score="-0.984762906" /energy="-12.6" /TU="NA" /idTUdmin="U2074" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2272745..2273131) /gene="yraH" /locus_tag="BSU_26940" /old_locus_tag="BSU26940" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase" /protein_id="NP_390571.1" /db_xref="EnsemblGenomes-Gn:BSU26940" /db_xref="EnsemblGenomes-Tr:CAB14635" /db_xref="GOA:O07918" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12272" /db_xref="UniProtKB/Swiss-Prot:O07918" /translation="MKLLQIRLLVNDFKKSVEFYKDSLGLPISWLENEMEYALFDNGE TKIELLSRETMAEIVGEEKKSLEGEAQSKFLLQFKVEDVDKTYDDLHEKGVKCENKPH DRKEWSARVAHFRDPDHNLIEIYKML*" /label="yraH CDS" gene complement(2272745..2273131) /gene="yraH" /locus_tag="BSU_26940" /old_locus_tag="BSU26940" /label="yraH gene" misc_feature complement(2273173..2273189) /Source="Nicolas_upshift_promotors" /id="U2074" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.245754245754246" /psig="0.575424575424575" /xcortree=1510 /SigmaFactorBS="tgcacttaaatctgaaataagggtgaagtatggaaacttgac atagtgctgtcaggtttcTTTGGTATCATTAAATTggatgaccagtaaaagtatggtt t" /listShort="yraH, S1015" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2273189) /Source="Nicolas_upshifts" /id="U2074" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.245754245754246" /psig="0.575424575424575" /xcortree=1510 /SigmaFactorBS="tgcacttaaatctgaaataagggtgaagtatggaaacttgac atagtgctgtcaggtttcTTTGGTATCATTAAATTggatgaccagtaaaagtatggtt t" /listShort="yraH, S1015" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2273322..2273328 /Source="Nicolas_upshift_promotors" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2273343..2273354 /Source="Nicolas_upshift_promotors" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2273343 /Source="Nicolas_upshifts" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="upshifts" CDS 2273380..2273625 /gene="yraG" /locus_tag="BSU_26950" /old_locus_tag="BSU26950" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390572.1" /db_xref="EnsemblGenomes-Gn:BSU26950" /db_xref="EnsemblGenomes-Tr:CAB14636" /db_xref="GOA:O07919" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG12271" /db_xref="UniProtKB/Swiss-Prot:O07919" /translation="MDHQTLAAHEAVDLHEIVNFKTLCIAKSKLMQGLVFDQELKDLM EKDVQQSIQDLTELQAVYERASFQAPVPQSRPTPIIN*" /label="yraG CDS" gene 2273380..2273625 /gene="yraG" /locus_tag="BSU_26950" /old_locus_tag="BSU26950" /label="yraG gene" CDS 2273643..2274011 /gene="yraF" /locus_tag="BSU_26960" /old_locus_tag="BSU26960" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390573.1" /db_xref="EnsemblGenomes-Gn:BSU26960" /db_xref="EnsemblGenomes-Tr:CAB14637" /db_xref="GOA:O07949" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG12270" /db_xref="UniProtKB/Swiss-Prot:O07949" /translation="MNNDHLDPINSLNVPELADTTFAMDFLIRAKEGVRNTAVALTET ASPDVRALLRKQLMQGIAMHQEITELMISKKWFHPYELSEQYKLDQLSAKNTIMVGNM NLFPDETNRKGMFDRTPDEH*" /label="yraF CDS" gene 2273643..2274011 /gene="yraF" /locus_tag="BSU_26960" /old_locus_tag="BSU26960" /label="yraF gene" CDS 2274030..2275166 /gene="adhB" /locus_tag="BSU_26970" /old_locus_tag="BSU26970" /EC_number="1.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7926692, 17586670; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (involving bacillithiol)" /protein_id="NP_390574.2" /db_xref="EnsemblGenomes-Gn:BSU26970" /db_xref="EnsemblGenomes-Tr:CAB14638" /db_xref="GOA:O06012" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR027399" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11902" /db_xref="UniProtKB/Swiss-Prot:O06012" /translation="MKAVTYQGIKNVVVKDVPDPKIEKSDDMIIKVTSTAICGSDLHL IHGFIPNMQEDYVIGHEPMGIVEEVGSGVTKLKKGDRVIIPFNIACGECFFCKNQLES QCDQSNDNGEMGAYFGYSGQTGGYPGGQAEYLRVPFANFTHFKIPESCEEPDEKLSVI ADAMTTGFWSVDNAGVKKGDTVIVLGCGPVGLFAQKFCWLKGAKRVIAVDYVNYRLQH AKRTNKVEIVNFEDHENTGNYLKEITKGGADVVIDAVGMDGKMSDLEFLASGLKLHGG TMSALVIASQAVRKGGTIQITGVYGGRYNGFPLGDIMQRNVNIRSGQAPVIHYMPYMF ELVSTGKIDPGDVVSHVLPLSEAKHGYDIFDSKMDDCIKVVLKP*" /label="adhB CDS" gene 2274030..2275166 /gene="adhB" /locus_tag="BSU_26970" /old_locus_tag="BSU26970" /label="adhB gene" CDS 2275185..2275382 /gene="yraE" /locus_tag="BSU_26980" /old_locus_tag="BSU26980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390575.1" /db_xref="EnsemblGenomes-Gn:BSU26980" /db_xref="EnsemblGenomes-Tr:CAB14639" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG13780" /db_xref="UniProtKB/Swiss-Prot:O06011" /translation="MEYALHEVLEVQEMTAFKTLCLTKSKTMKALVSDPKLKEIMQQD VDITTRQLQEFASILSNAKQE*" /label="yraE CDS" gene 2275185..2275382 /gene="yraE" /locus_tag="BSU_26980" /old_locus_tag="BSU26980" /label="yraE gene" CDS 2275398..2275697 /gene="yraD" /locus_tag="BSU_26990" /old_locus_tag="BSU26990" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390576.1" /db_xref="EnsemblGenomes-Gn:BSU26990" /db_xref="EnsemblGenomes-Tr:CAB14640" /db_xref="GOA:O06010" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG13779" /db_xref="UniProtKB/Swiss-Prot:O06010" /translation="MNPIIEYLTGMNVLTDQIIAMDLLISAKNGVRNYAMAATEAGTP EVKEVLIRHLEEALDMHEQLSSYMMEKGWYHPWNPDEQVKLNLKNIDTAIQLPTL*" /label="yraD CDS" gene 2275398..2275697 /gene="yraD" /locus_tag="BSU_26990" /old_locus_tag="BSU26990" /label="yraD gene" downshifts 2275688 /Source="Nicolas_upshifts" /id="D1378" /incds=0 /nref=11 /ntot=39 /MaxReadThrough="1.62449" /MaxDrop="3.8153" /score="-8.57687054" /energy="-10.7" /TU="NA" /idTUdmin="U2075" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2275960..2276382) /gene="adhR" /locus_tag="BSU_27000" /old_locus_tag="BSU27000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075, 17962296, 19170879" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 17962296, 19170879; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator regulated by thiol-alkylation" /protein_id="NP_390578.2" /db_xref="EnsemblGenomes-Gn:BSU27000" /db_xref="EnsemblGenomes-Tr:CAB14642" /db_xref="GOA:O06008" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG13777" /db_xref="UniProtKB/Swiss-Prot:O06008" /translation="MNIAQVAKQFGLTAATLRYYERVGLIPPVKRKDSGIRDYDEEDI KWIEFIKCMRNAGLSIEALIEYTTLFTEGDRTVEARKNILADERQRLIEKRKEIDETI KRLDTKIKDYDGKLRENEAKLKSRPKTESLHGSVEQRR*" /label="adhR CDS" gene complement(2275960..2276382) /gene="adhR" /locus_tag="BSU_27000" /old_locus_tag="BSU27000" /label="adhR gene" promotor_-35 2276380..2276383 /Source="Nicolas_upshift_promotors" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="promotor_-35" promotor_-10 2276399..2276418 /Source="Nicolas_upshift_promotors" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="promotor_-10" S_feature 2276414..2276564 /Source="Nicolas_S_feature" /locus_tag="new_2755836_2755986" /HighExp="Diami, dia15, dia5, H2O2, S8, Paraq, S5, G180, S6, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S1016" upshifts 2276414 /Source="Nicolas_upshifts" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="upshifts" promotor_-10 complement(2276417..2276436) /Source="Nicolas_upshift_promotors" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2276424) /Source="Nicolas_upshifts" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2276450..2276457) /Source="Nicolas_upshift_promotors" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2276533..2276552) /Source="Nicolas_upshift_promotors" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="promotor_-10" upshifts complement(2276541) /Source="Nicolas_upshifts" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="upshifts" CDS 2276565..2276759 /gene="yrzP" /locus_tag="BSU_27009" /old_locus_tag="BSU27009" /EC_number="4.1.1.44" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17962296, 19170879; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxymuconolactone decarboxylase" /protein_id="YP_009513988.1" /db_xref="EnsemblGenomes-Gn:BSU27009" /db_xref="EnsemblGenomes-Tr:CAX52671" /db_xref="InterPro:IPR029032" /db_xref="UniProtKB/TrEMBL:C0H460" /translation="MANKHTAGREQLGEFAPKFAELHDDVLFGDIWAREEELSSRDRS MITVSALITDCFSAYKSGSF*" /label="yrzP CDS" gene 2276565..2276759 /gene="yrzP" /locus_tag="BSU_27009" /old_locus_tag="BSU27009" /label="yrzP gene" promotor_-35 complement(2276567..2276574) /Source="Nicolas_upshift_promotors" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="promotor_-35" promotor_-35 2276777..2276784 /Source="Nicolas_upshift_promotors" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="promotor_-35" promotor_-10 2276800..2276819 /Source="Nicolas_upshift_promotors" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="promotor_-10" upshifts 2276804 /Source="Nicolas_upshifts" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="upshifts" S_feature 2276805..2276889 /Source="Nicolas_S_feature" /locus_tag="new_2756227_2756311" /HighExp="LBGstat, dia15, Diami, LPhT, LBGtran, dia5, M40t90, Lbtran, H2O2, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.987, 0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S1017" CDS 2276890..2277939 /gene="adhA" /locus_tag="BSU_27010" /old_locus_tag="BSU27010" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19170879; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase; carbonyl stressresponse" /protein_id="NP_390579.2" /db_xref="EnsemblGenomes-Gn:BSU27010" /db_xref="EnsemblGenomes-Tr:CAB14643" /db_xref="GOA:C0SPA5" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12562" /db_xref="UniProtKB/Swiss-Prot:C0SPA5" /translation="MCNQHQTRVLSVSHAKAKFEQTTIERRGLRPHDVLIDIKFSGIC HSDIHSAFDEWGGGIFPMVPGHEIAGVVTAVGTKVTKLAVGDRVGVGCFVDSCGECEY CLNAEEQFCTKGVVQTYNSVDYDGNPTYGGYSQKIVVTDRFVVRIPDRLEMDVASPLL CAGITTYSPLKHWNVGPGKKVAIVGVGGLGHLAIQFAHAMGAEVTVLSRSMNKKEEAL ELGANHYFATSDPATFTALAGRFDVILNTVSANLDVDAYLSMLRIDGTLVSVGAPAKP DTYSVFSLIMGRRSIAGSLVGGIQETQEMLDFAAEHGIEPKIEVIGADQVDEAYERIL RSDVRYRFVIDISTL*" /label="adhA CDS" gene 2276890..2277939 /gene="adhA" /locus_tag="BSU_27010" /old_locus_tag="BSU27010" /label="adhA gene" promotor_-35 2278007..2278014 /Source="Nicolas_upshift_promotors" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2278029..2278048 /Source="Nicolas_upshift_promotors" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2278042 /Source="Nicolas_upshifts" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="upshifts" CDS 2278070..2278579 /gene="sufL" /locus_tag="BSU_27020" /old_locus_tag="BSU27020" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12775685, 17257049, 17933887, 24330391, 26774339; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deglycase; general stress protecting enzyme; protects against methylglyoxal toxicity" /protein_id="NP_390580.2" /db_xref="EnsemblGenomes-Gn:BSU27020" /db_xref="EnsemblGenomes-Tr:CAB14644" /db_xref="GOA:O06006" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR006286" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13776" /db_xref="UniProtKB/Swiss-Prot:O06006" /translation="MSKKIAVLVTDQFEDIEYTSPVKAYEEAGYSVVAIDLEAGKEVT GKHGEKVKIDKAISDVDASDFDALLIPGGFSPDLLRADDRPGEFAKAFVENKKPVFAI CHGPQVLIDTDLLKGKDITGYRSIRKDLINAGANYKDAEVVVSHNIVTSRTPDDLEAF NRESLNLLK*" /label="sufL CDS" gene 2278070..2278579 /gene="sufL" /locus_tag="BSU_27020" /old_locus_tag="BSU27020" /label="sufL gene" downshifts 2278548 /Source="Nicolas_upshifts" /id="D1379" /incds=0 /nref=178 /ntot=254 /MaxReadThrough="4.08169" /MaxDrop="5.1444" /score="24.8267602" /energy="-16.3" /TU="U2080" /idTUdmin="U2076" /TUdmin=528 /isTUend="FALSE" /label="downshifts" S_feature 2278593..2279698 /Source="Nicolas_S_feature" /locus_tag="new_2758015_2759120" /HighExp="Diami, dia5, Etha, dia15, LPhT, H2O2, Lbstat, Salt, Fru, Paraq" /AntisenseName="sacC" /AntisenseCor="0.18236909579254801" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.926" /label="S1018" CDS complement(2278621..2280654) /gene="sacC" /locus_tag="BSU_27030" /old_locus_tag="BSU27030" /EC_number="3.2.1.7" /EC_number="3.2.1.65" /EC_number="3.2.1.80" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7646030, 8057358, 10217495, 12224641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7646030, 8057358, 10217495, 12224641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="levanase" /protein_id="NP_390581.1" /db_xref="EnsemblGenomes-Gn:BSU27030" /db_xref="EnsemblGenomes-Tr:CAB14645" /db_xref="GOA:P05656" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018053" /db_xref="InterPro:IPR023296" /db_xref="PDB:4AZZ" /db_xref="PDB:4B1L" /db_xref="PDB:4B1M" /db_xref="SubtiList:BG10320" /db_xref="UniProtKB/Swiss-Prot:P05656" /translation="MKKRLIQVMIMFTLLLTMAFSADAADSSYYDEDYRPQYHFTPEA NWMNDPNGMVYYAGEYHLFYQYHPYGLQWGPMHWGHAVSKDLVTWEHLPVALYPDEKG TIFSGSAVVDKNNTSGFQTGKEKPLVAIYTQDREGHQVQSIAYSNDKGRTWTKYAGNP VIPNPGKKDFRDPKVFWYEKEKKWVMVLAAGDRILIYTSKNLKQWTYASEFGQDQGSH GGVWECPDLFELPVDGNPNQKKWVMQVSVGNGAVSGGSGMQYFVGDFDGTHFKNENPP NKVLWTDYGRDFYAAVSWSDIPSTDSRRLWLGWMSNWQYANDVPTSPWRSATSIPREL KLKAFTEGVRVVQTPVKELETIRGTSKKWKNLTISPASHNVLAGQSGDAYEINAEFKV SPGSAAEFGFKVRTGENQFTKVGYDRRNAKLFVDRSESGNDTFNPAFNTGKETAPLKP VNGKVKLRIFVDRSSVEVFGNDGKQVITDIILPDRSSKGLELYAANGGVKVKSLTIHP LKKVWGTTPFMSNMTGWTTVNGTWADTIEGKQGRSDGDSFILSSASGSDFTYESDITI KDGNGRGAGALMFRSDKDAKNGYLANVDAKHDLVKFFKFENGAASVIAEYKTPIDVNK KYHLKTEAEGDRFKIYLDDRLVIDAHDSVFSEGQFGLNVWDATAVFQNVTKES*" /label="sacC CDS" gene complement(2278621..2280654) /gene="sacC" /locus_tag="BSU_27030" /old_locus_tag="BSU27030" /label="sacC gene" downshifts complement(2278646) /Source="Nicolas_upshifts" /id="D1380" /incds=0 /nref=14 /ntot=60 /MaxReadThrough="0.56875" /MaxDrop="5.09923" /score="-2.07442916" /energy="-14.2" /TU="NA" /idTUdmin="U2081" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2280563..2280730) /locus_tag="BSU_27035" /old_locus_tag="BSU27035" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513989.1" /translation="MPETDQLAQQSLLKVFKHEERSEGTNEKETDSSHDHVHPAVDYG IFGRCSRFKLL*" /label="hypothetical protein CDS" gene complement(2280563..2280730) /locus_tag="BSU_27035" /old_locus_tag="BSU27035" /label="gene" S_feature complement(2280655..2280810) /Source="Nicolas_S_feature" /locus_tag="new_2760077_2760232_c" /HighExp="UNK1, Fru, B60, T0.30H, M40t90, M0t90, ferm, LPh, GM-0.2, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.886" /TUlongSig="NA" /TUlongPSig="NA" /label="S1019" CDS complement(2280811..2281638) /gene="levG" /locus_tag="BSU_27040" /old_locus_tag="BSU27040" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IID component" /protein_id="NP_390582.1" /db_xref="EnsemblGenomes-Gn:BSU27040" /db_xref="EnsemblGenomes-Tr:CAB14646" /db_xref="GOA:P26382" /db_xref="InterPro:IPR004704" /db_xref="SubtiList:BG10319" /db_xref="UniProtKB/Swiss-Prot:P26382" /translation="MEKEKRLTKKEIFSMFIRSNFLLGSFNFERVQAMGYCYVMIPAI KKLYGPGAKRNEALQRHLEWFNTHPWLTAPIFGVTAAMEEEMANNKGIDGKAISGMKI GLMGPIAGVGDPIFWGTIRPVLAALGASLALGGNIAGPLLFFFLLNAIRLSTKYYGLK YGYVKGMEILQDLAGNRIQKLTEGASILGLFVMGALVSKWTTINIPIVVSRIKDESGK VDVQTVQNVLDSIMPGALPLGLTLLVAWMLRKGVNPLLIICGIFVIGILGYWAGFLA* " /label="levG CDS" gene complement(2280811..2281638) /gene="levG" /locus_tag="BSU_27040" /old_locus_tag="BSU27040" /label="levG gene" CDS complement(2281659..2282468) /gene="levF" /locus_tag="BSU_27050" /old_locus_tag="BSU27050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIC component" /protein_id="NP_390583.1" /db_xref="EnsemblGenomes-Gn:BSU27050" /db_xref="EnsemblGenomes-Tr:CAB14647" /db_xref="GOA:P26381" /db_xref="InterPro:IPR004700" /db_xref="SubtiList:BG10318" /db_xref="UniProtKB/Swiss-Prot:P26381" /translation="MSSLQIILLLIIAAITGIASVLDEGQTHRPLVACTLVGLVLGDL KTGIILGGTLELMALGWMNVGLAMAPDTAIASVISTILVITADQGIGEGIAVAVALAA AGQALTIFVRTITVFFIHRADQYAKAGNIKGIEIMHITAMVFQALRVMIPTLIVALIS VSAVQAFLGNIPDVITKGLQIGGGIIVVVGYAMVINMMNIPYLKPFFYIGFLLAAFTD FNLVGFGALGLCLALLYQQVMQKQSAHGAVAAASDSGSVAVYDDDDDDLDA*" /label="levF CDS" gene complement(2281659..2282468) /gene="levF" /locus_tag="BSU_27050" /old_locus_tag="BSU27050" /label="levF gene" CDS complement(2282485..2282973) /gene="levE" /locus_tag="BSU_27060" /old_locus_tag="BSU27060" /EC_number="2.7.1.202" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 9622354, 10589728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 9622354, 10589728; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIB component" /protein_id="NP_390584.1" /db_xref="EnsemblGenomes-Gn:BSU27060" /db_xref="EnsemblGenomes-Tr:CAB14648" /db_xref="GOA:P26380" /db_xref="InterPro:IPR004720" /db_xref="InterPro:IPR018455" /db_xref="InterPro:IPR036667" /db_xref="PDB:1BLE" /db_xref="SubtiList:BG10317" /db_xref="UniProtKB/Swiss-Prot:P26380" /translation="MNIVLARIDDRFIHGQILTRWIKVHAADRIIVVSDDIAQDEMRK TLILSVAPSNVKASAVSVSKMAKAFHSPRYEGVTAMLLFENPSDIVSLIEAGVPIKTV NVGGMRFENHRRQITKSVSVTEQDIKAFETLSDKGVKLELRQLPSDASEDFVQILRNV TK*" /label="levE CDS" gene complement(2282485..2282973) /gene="levE" /locus_tag="BSU_27060" /old_locus_tag="BSU27060" /label="levE gene" CDS complement(2282973..2283413) /gene="levD" /locus_tag="BSU_27070" /old_locus_tag="BSU27070" /EC_number="2.7.1.202" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIA component" /protein_id="NP_390585.1" /db_xref="EnsemblGenomes-Gn:BSU27070" /db_xref="EnsemblGenomes-Tr:CAB14649" /db_xref="GOA:P26379" /db_xref="InterPro:IPR004701" /db_xref="InterPro:IPR013789" /db_xref="InterPro:IPR033887" /db_xref="InterPro:IPR036662" /db_xref="SubtiList:BG10316" /db_xref="UniProtKB/Swiss-Prot:P26379" /translation="MISVIISGHGDFPIALKESSGMIFGEENNLIAVPFFKGEGIQTL QEKYHQALKDIPEEHEVLFLVDIFGGTPYNAAASFIAEDQRMDMAAGVNLPILLEVLS LREHLALKDLLNNLKAMSQQSFQVCSEHLEKVKTANQDTREDEL*" /label="levD CDS" gene complement(2282973..2283413) /gene="levD" /locus_tag="BSU_27070" /old_locus_tag="BSU27070" /label="levD gene" downshifts 2283410 /Source="Nicolas_upshifts" /id="D1381" /incds=0 /nref=2 /ntot=5 /MaxReadThrough="0.496260000000001" /MaxDrop="4.58461" /score="24.8267602" /energy="-16.3" /TU="NA" /idTUdmin="U2080" /TUdmin=3740 /isTUend="FALSE" /label="downshifts" misc_feature complement(2283450..2283468) /Source="Nicolas_upshift_promotors" /id="U2081" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.886113886113886" /psig="0.886113886113886" /xcortree=1498 /SigmaFactorBS="ttgctattggctgaaataacaatgaaaacgcttaacacaact gtgtTGGCACGATCCTTGCATTAtatatggatgtacaaaacaggaaaggagcaataga t" /listShort="levD, levE, levF, levG, S1019, sacC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2283454) /Source="Nicolas_upshifts" /id="U2081" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.886113886113886" /psig="0.886113886113886" /xcortree=1498 /SigmaFactorBS="ttgctattggctgaaataacaatgaaaacgcttaacacaact gtgtTGGCACGATCCTTGCATTAtatatggatgtacaaaacaggaaaggagcaataga t" /listShort="levD, levE, levF, levG, S1019, sacC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2283603..2286410) /gene="levR" /locus_tag="BSU_27080" /old_locus_tag="BSU27080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1619665, 1900939, 7592487, 8057358, 9622354, 10589728, 19202299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1619665, 1900939, 7592487, 8057358, 9622354, 10589728, 19202299; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (NifA/NtrC family)" /protein_id="NP_390586.2" /db_xref="EnsemblGenomes-Gn:BSU27080" /db_xref="EnsemblGenomes-Tr:CAB14650" /db_xref="GOA:P23914" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004701" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033887" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036662" /db_xref="SubtiList:BG10677" /db_xref="UniProtKB/Swiss-Prot:P23914" /translation="MRRIDKIYHQLKHNFHDSTLDHLLKIQGNSAKEIAEQLKMERSN VSFELNNLVRSKKVIKIKTFPVRYIPVEIAEKLFNKKWDTEMMEVKDLQAFSGNSKQN HQHISTNPLELMIGAKGSLKKAISQAKAAVFYPPNGLHMLLLGPTGSGKSLFANRIYQ FAIYSDILKAGAPFITFNCADYYNNPQLLLSQLFGHKKGSFTGAAEDKAGLVEQANGG ILFMDEIHRLPPEGQEMLFYFIDSGSYNRLGESEHKRTSNVLFICATTENPSSALLKT FLRRIPMTIHIPSLEERSLNERVDLTTFLLGKEAERIKKNLSVHIDVYNALIHSAKFG NVGQLKSNVQLVCAHGFLHNLDRNEVIELTVRDLPDEIKQEWMSSSKNMQRSKAISEY VNITTIISPIVEDETTKIDEDLSFNLYHLIEEKVKTLMKEGLSKKDINQYILTDVHLH VRSFFHHQAFQKDNLLTFVEDDVIQMTKQLKEIAEHELDCTFDRKFIYFLSMHIDAFL KRGKQIDVLNTQETDEIRDTHVKEYRVAMIFKDKIQEYFKVAIPEIEVIYLTMLIHSI KSLKENKRVGIIVAAHGNSTASSMVEVATELLGSTPIAAVDMPLTVSPSDILECVAEK MKQVDEGEGVLMLVDMGSLAMLESRLEEKTGISIKTISNVTTSMVLDAVRKVNYLNLN LHAIYQSVTKDFIELWERQPAASGKKKALVSICTTGSGTAKKLEDILTTIVNKASDTP IHILTVSSIKLANSIKEIEKEYEILATVGTKDPKINAPHVSLEVLIEGEGEKLIQQAI TKGSISLSNGLNEANIIVRELCEDSLKKYLVFLNPHHVIDMLLEWLQTVQDELGVIFN NAVLIKVIMHTAFAFERVIKQNPIAFSEEEEINDQLKEMVYVTERTLAPYEEKLGLRI SDDEKLFIAAIFAEEVHGQLF*" /label="levR CDS" gene complement(2283603..2286410) /gene="levR" /locus_tag="BSU_27080" /old_locus_tag="BSU27080" /label="levR gene" misc_feature complement(2286626..2286645) /Source="Nicolas_upshift_promotors" /id="U2082" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.743256743256743" /psig="0.957042957042957" /xcortree=2981 /SigmaFactorBS="attcattttttgtcattgattattttgacatcattacattcc ccgagAATGATAAACTGTTTACTGAttattacttttgaaggggactggccctccagaa c" /listShort="levR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2286632) /Source="Nicolas_upshifts" /id="U2082" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.743256743256743" /psig="0.957042957042957" /xcortree=2981 /SigmaFactorBS="attcattttttgtcattgattattttgacatcattacattcc ccgagAATGATAAACTGTTTACTGAttattacttttgaaggggactggccctccagaa c" /listShort="levR" /GFF_Attribute="listLong" /label="upshifts" CDS 2286957..2287097 /locus_tag="BSU_27085" /old_locus_tag="BSU27085" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513990.1" /translation="MTFLFYSAIQVESRVKNRATRHVTALKIVLKFKNKSIYSFKCYN IR*" /label="hypothetical protein CDS" gene 2286957..2287097 /locus_tag="BSU_27085" /old_locus_tag="BSU27085" /label="gene" misc_feature 2287078..2287097 /Source="Nicolas_upshift_promotors" /id="U2083" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.929070929070929" /psig="0.997002997002997" /xcortree=1762 /SigmaFactorBS="agcacttaaaatagttttaaaatttaaaaataaaagtatcta ttcttttaAATGTTATAATATCCGATAAaactttactcatctttttattactggagga a" /listShort="aapA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2287088 /Source="Nicolas_upshifts" /id="U2083" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.929070929070929" /psig="0.997002997002997" /xcortree=1762 /SigmaFactorBS="agcacttaaaatagttttaaaatttaaaaataaaagtatcta ttcttttaAATGTTATAATATCCGATAAaactttactcatctttttattactggagga a" /listShort="aapA" /GFF_Attribute="listLong" /label="upshifts" CDS 2287136..2288524 /gene="aapA" /locus_tag="BSU_27090" /old_locus_tag="BSU27090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 17608695, 22084243; Product type t: transporter" /codon_start=1 /transl_table=11 /product="small amino acid permease" /protein_id="NP_390587.2" /db_xref="EnsemblGenomes-Gn:BSU27090" /db_xref="EnsemblGenomes-Tr:CAB14651" /db_xref="GOA:O06005" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12556" /db_xref="UniProtKB/Swiss-Prot:O06005" /translation="MIGNSSKDNFGQQQKLSRGLKNRHIQLMAIGGAIGTGLFLGSGK SIHFAGPSILFAYLITGVFCFFIMRSLGELLLSNAGYHSFVDFVRDYLGNMAAFITGW TYWFCWISLAMADLTAVGIYTQYWLPDVPQWLPGLLALIILLIMNLATVKLFGELEFW FALIKVIAILALIVTGILLIAKGFSAASGPASLNNLWSHGGMFPNGWHGFILSFQMVV FAFVGIELVGLTAGETENPQKVIPKAINQIPVRILLFYVGALFVIMCIYPWNVLNPNE SPFVQVFSAVGIVVAASLINFVVLTSAASAANSALFSTSRMVYSLAKDHHAPGLLKKL TSSNVPSNALFFSSIAILIGVSLNYLMPEQVFTLITSVSTICFIFIWGITVICHLKYR KTRQHEAKANKFKMPFYPLSNYLTLAFLAFILVILALANDTRIALFVTPVWFVLLIIL YKVQTRRGHKVK*" /label="aapA CDS" gene 2287136..2288524 /gene="aapA" /locus_tag="BSU_27090" /old_locus_tag="BSU27090" /label="aapA gene" downshifts 2288513 /Source="Nicolas_upshifts" /id="D1382" /incds=0 /nref=7 /ntot=120 /MaxReadThrough="0.96985" /MaxDrop="3.54068" /score="11.8049306" /energy="-13" /TU="NA" /idTUdmin="U2083" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" S_feature complement(2288546..2288619) /Source="Nicolas_S_feature" /locus_tag="new_2767968_2768041_c" /HighExp="MG 120, LBGstat, MG 150, MG 90, S0, HPh, HiOs, GM-0.1, aero, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1020" downshifts complement(2288588) /Source="Nicolas_upshifts" /id="D1383" /incds=0 /nref=11 /ntot=121 /MaxReadThrough="1.79954" /MaxDrop="4.59487" /score="37.881034" /energy="-13" /TU="NA" /idTUdmin="U2084" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2288620..2289252) /gene="yrhP" /locus_tag="BSU_27100" /old_locus_tag="BSU27100" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16098526, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid exporter" /protein_id="NP_390588.1" /db_xref="EnsemblGenomes-Gn:BSU27100" /db_xref="EnsemblGenomes-Tr:CAB14652" /db_xref="GOA:O05406" /db_xref="InterPro:IPR001123" /db_xref="InterPro:IPR004778" /db_xref="SubtiList:BG12304" /db_xref="UniProtKB/Swiss-Prot:O05406" /translation="MHSLLAYIPIAAMMVIIPGADTMLVMKNTLRYGPKAGRYNILGL ATGLSFWTVIAILGLSVVIAKSVILFTTIKYLGAAYLIYLGVKSFFAKSMFSLDDMQS QAKNMASSPKRYYKTSFMQGSLSNILNPKTVLVYVTIMPQFINLNGNINQQLIILASI LTLLAVLWFLFLVYIIDYAKKWMKNSKFQKVFQKITGIILVGFGIKTGLS*" /label="yrhP CDS" gene complement(2288620..2289252) /gene="yrhP" /locus_tag="BSU_27100" /old_locus_tag="BSU27100" /label="yrhP gene" downshifts complement(2288676) /Source="Nicolas_upshifts" /id="D1384" /incds=0 /nref=4 /ntot=132 /MaxReadThrough="4.46187" /MaxDrop="3.11632" /score="37.881034" /energy="-13" /TU="U2084" /idTUdmin="U2084" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2289306..2289325) /Source="Nicolas_upshift_promotors" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2289317) /Source="Nicolas_upshifts" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2289331..2289337 /Source="Nicolas_upshift_promotors" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2289340..2289347) /Source="Nicolas_upshift_promotors" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2289351..2289370 /Source="Nicolas_upshift_promotors" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2289356 /Source="Nicolas_upshifts" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="upshifts" CDS 2289405..2290232 /gene="yrhO" /locus_tag="BSU_27110" /old_locus_tag="BSU27110" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator controlling amino acid export" /protein_id="NP_390589.1" /db_xref="EnsemblGenomes-Gn:BSU27110" /db_xref="EnsemblGenomes-Tr:CAB14653" /db_xref="InterPro:IPR002831" /db_xref="InterPro:IPR021586" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12303" /db_xref="UniProtKB/Swiss-Prot:O05405" /translation="MKENMLDILKNLNFTEYESKAYLALLQESPLTGYAVAKKSGVPR SKIYEVLESLVIRGDVFVSHGNTPQYVPVPAKELIKNRRLKAEEHFDQAEKYFEKFEQ TANDRENIWNITGRSEILEKVKACILSAKKRILLEIWKEDFKEIEAELKQAAEQGVIV TIIAYGDIVSDFANVYLHDMSSEITEEYDGRWLVYSGDDSEVVAGIVSLGNDSRAAWT MHVGLVMPITEVIIHDLYLMEILKKHRELLEESFGKNLIQLRRKFSIHSDFKKHYLE* " /label="yrhO CDS" gene 2289405..2290232 /gene="yrhO" /locus_tag="BSU_27110" /old_locus_tag="BSU27110" /label="yrhO gene" downshifts 2290228 /Source="Nicolas_upshifts" /id="D1385" /incds=0 /nref=57 /ntot=233 /MaxReadThrough="0.74814" /MaxDrop="5.12635" /score="6.64108595" /energy="-9.5" /TU="NA" /idTUdmin="U2085" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2290345..2290354 /Source="Nicolas_upshift_promotors" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2290367..2290382 /Source="Nicolas_upshift_promotors" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2290372 /Source="Nicolas_upshifts" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="upshifts" CDS 2290428..2290928 /gene="sigV" /locus_tag="BSU_27120" /old_locus_tag="BSU27120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16274938, 21926231, 23687273, 26901131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16274938, 21926231, 23687273, 26901131; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor (sigma(V))" /protein_id="NP_390590.1" /db_xref="EnsemblGenomes-Gn:BSU27120" /db_xref="EnsemblGenomes-Tr:CAB14654" /db_xref="GOA:O05404" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11974" /db_xref="UniProtKB/Swiss-Prot:O05404" /translation="MKKKQTTKALLVTCITDHKQDFYRLAFSYVKNQDDALDIVQESI KKALSSVETVRNPETIKSWFYKILVRTAIDFLRKQKKIRVMDDETIEFLSKGKEDHYK DTDLHEALDELPYRYKTIIILRFFEDLKLEEIAEITGENTNTVKTRLYRALKLMRIQL TKEDLS*" /label="sigV CDS" gene 2290428..2290928 /gene="sigV" /locus_tag="BSU_27120" /old_locus_tag="BSU27120" /label="sigV gene" CDS 2290928..2291785 /gene="rsiV" /locus_tag="BSU_27130" /old_locus_tag="BSU27130" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16274938, 23687273, 26901131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16274938, 23687273, 26901131; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma(V) factor" /protein_id="NP_390591.1" /db_xref="EnsemblGenomes-Gn:BSU27130" /db_xref="EnsemblGenomes-Tr:CAB14655" /db_xref="GOA:O05403" /db_xref="InterPro:IPR021729" /db_xref="InterPro:IPR025303" /db_xref="InterPro:IPR037126" /db_xref="PDB:5JEN" /db_xref="SubtiList:BG12302" /db_xref="UniProtKB/Swiss-Prot:O05403" /translation="MDKRLQQLREEYKNVQIPKELDIIVEKALQQEPKKKRIVMWPTS AAIAAAILFTALVNINPDAAQAMSKIPVIGKIVKAITFIEIKEEKDQSSIDVKTPALS GLSNKELENSINEKYLKESQQLYKEFIQSTSKNKKGHLSIYSDYETVTDTPDLLSIRR NIETTQASSYTQSRYITIDKKNDILLTLKSLFKDERYIKVISQNIKEQMKQQMKEDPN KIYWLTDEDAEPFKTILPDQTFYITEDHKLVISFDEYEVAPGYMGVTEFTIPTGVISN LLVGERYIR*" /label="rsiV CDS" gene 2290928..2291785 /gene="rsiV" /locus_tag="BSU_27130" /old_locus_tag="BSU27130" /label="rsiV gene" promotor_-10 complement(2291803..2291814) /Source="Nicolas_upshift_promotors" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2291822) /Source="Nicolas_upshifts" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2291829..2291835) /Source="Nicolas_upshift_promotors" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2291896..2293800 /gene="oatA" /locus_tag="BSU_27140" /old_locus_tag="BSU27140" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1521192, 15661003, 21135105, 21586574, 21856855, 21926231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1521192, 15661003, 21135105, 21586574, 21856855, 21926231; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan O-acetyltransferase" /protein_id="NP_390592.1" /db_xref="EnsemblGenomes-Gn:BSU27140" /db_xref="EnsemblGenomes-Tr:CAB14656" /db_xref="GOA:O05402" /db_xref="InterPro:IPR002656" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12301" /db_xref="UniProtKB/Swiss-Prot:O05402" /translation="MYHKTQHHRYIPGLDGLRAFAVLSVITYHLNFNWANGGFIGVDI FFVLSGYLITSILLPAYGNDINLDFRDFWVRRIRRLLPAAYLMIFSTVVWVVLFDREL LHTVRGDAISSLFYMSNWWFIFHKLSYFDSFGSPSPLKNLWSLAIEEQFYIIWPMFLV VGMYIMKSRARLAAVISLLVLCSAVMMSVLYEPGGDPSRVYYGTDTRSFELLIGCALA LVWPMKRLSSNRLPSKLKHTLHATEFLAFCILVLCVYFTDEYEPFLYRGGMLFISVTA AILIACVCHPSSFLGNLLSWRPLRWLGTRSYGIYLWHYPVIVLSTPVQEIGNPVFWHI VLKVIVTCILAELSYHFIEKPIRTQGFRSFSRRVFIHRIKEWKTTSVISKMSIGFIIF AILIFAGGLSGLAGEQKHPTKWTYSSQETNADTSQASGDKKNAAADKKHNPEQKTTDS NQGQKENKDSGQETHKKKDTQSQQLKKPADTAKEVLAIGDSVMLDISSHLRQSFSNVT IDGKVGRQMSQALELAREYKSFNQPNKAVIIELGTNGYFTNSQIEQLLQSFSKAHIYL VNTRVPRQWESKVNESLQQQAHAHQNVTLVDWHTEALQHPEYFTPDGVHLVPKGAKTL TALIVQAMKS*" /label="oatA CDS" gene 2291896..2293800 /gene="oatA" /locus_tag="BSU_27140" /old_locus_tag="BSU27140" /label="oatA gene" promotor_-35 2293881..2293887 /Source="Nicolas_upshift_promotors" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2293903..2293921 /Source="Nicolas_upshift_promotors" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2293909 /Source="Nicolas_upshifts" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="upshifts" CDS 2293934..2294224 /gene="yrhK" /locus_tag="BSU_27150" /old_locus_tag="BSU27150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21926231" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390593.1" /db_xref="EnsemblGenomes-Gn:BSU27150" /db_xref="EnsemblGenomes-Tr:CAB14657" /db_xref="GOA:O05401" /db_xref="InterPro:IPR025424" /db_xref="SubtiList:BG12300" /db_xref="UniProtKB/Swiss-Prot:O05401" /translation="MKGNEEHDIQKELKRYELFFKKRYKVLYTVNDFIIGAMFLVGSF FFFYDRLMSAGIWLFAIGSLLLLIRPTIRLIHDFHYRKHVEQQFKHQSSTDD*" /label="yrhK CDS" gene 2293934..2294224 /gene="yrhK" /locus_tag="BSU_27150" /old_locus_tag="BSU27150" /label="yrhK gene" S_feature 2294225..2294340 /Source="Nicolas_S_feature" /locus_tag="new_2773647_2773762" /HighExp="Etha, Salt, LPhT, HiTm, G135, LBGstat, G180, G150, Heat, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1021" promotor_-35 2294322..2294329 /Source="Nicolas_upshift_promotors" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2294342..2294467 /Source="Nicolas_S_feature" /locus_tag="new_2773764_2773889" /HighExp="Gly, G/S, Lbstat, C90, Pyr, LPhT, LoTm, Etha, T0.30H, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB" /TUshortPSig="0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1022" upshifts 2294342 /Source="Nicolas_upshifts" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2294343..2294361 /Source="Nicolas_upshift_promotors" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 2294361..2294461 /gene="surF" /locus_tag="BSU_misc_RNA_82" /product="small untranslated RNA expressed under sporulation conditions (SurF-AbrB)" /experiment="publication(s) with functional evidences, PMID:20709900, 25790031" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20709900, 25790031; Product type n: RNA" /label="surF RNA" gene 2294361..2294461 /gene="surF" /locus_tag="BSU_misc_RNA_82" /label="surF gene" downshifts 2294424 /Source="Nicolas_upshifts" /id="D1386" /incds=0 /nref=7 /ntot=129 /MaxReadThrough="3.60641" /MaxDrop="5.24336" /score="25.0079309" /energy="-15.8" /TU="U2089" /idTUdmin="U2088" /TUdmin=16 /isTUend="TRUE" /label="downshifts" CDS complement(2294468..2297632) /gene="cypB" /locus_tag="BSU_27160" /old_locus_tag="BSU27160" /EC_number="1.14.14.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11574077, 12775685" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574077, 12775685; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 CYP102A3" /protein_id="NP_390594.1" /db_xref="EnsemblGenomes-Gn:BSU27160" /db_xref="EnsemblGenomes-Tr:CAB14658" /db_xref="GOA:O08336" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR023206" /db_xref="InterPro:IPR029039" /db_xref="InterPro:IPR036396" /db_xref="SubtiList:BG12299" /db_xref="UniProtKB/Swiss-Prot:O08336" /translation="MKQASAIPQPKTYGPLKNLPHLEKEQLSQSLWRIADELGPIFRF DFPGVSSVFVSGHNLVAEVCDEKRFDKNLGKGLQKVREFGGDGLFTSWTHEPNWQKAH RILLPSFSQKAMKGYHSMMLDIATQLIQKWSRLNPNEEIDVADDMTRLTLDTIGLCGF NYRFNSFYRDSQHPFITSMLRALKEAMNQSKRLGLQDKMMVKTKLQFQKDIEVMNSLV DRMIAERKANPDENIKDLLSLMLYAKDPVTGETLDDENIRYQIITFLIAGHETTSGLL SFAIYCLLTHPEKLKKAQEEADRVLTDDTPEYKQIQQLKYIRMVLNETLRLYPTAPAF SLYAKEDTVLGGEYPISKGQPVTVLIPKLHRDQNAWGPDAEDFRPERFEDPSSIPHHA YKPFGNGQRACIGMQFALQEATMVLGLVLKHFELINHTGYELKIKEALTIKPDDFKIT VKPRKTAAINVQRKEQADIKAETKPKETKPKHGTPLLVLFGSNLGTAEGIAGELAAQG RQMGFTAETAPLDDYIGKLPEEGAVVIVTASYNGAPPDNAAGFVEWLKELEEGQLKGV SYAVFGCGNRSWASTYQRIPRLIDDMMKAKGASRLTAIGEGDAADDFESHRESWENRF WKETMDAFDINEIAQKEDRPSLSITFLSEATETPVAKAYGAFEGIVLENRELQTAAST RSTRHIELEIPAGKTYKEGDHIGILPKNSRELVQRVLSRFGLQSNHVIKVSGSAHMAH LPMDRPIKVVDLLSSYVELQEPASRLQLRELASYTVCPPHQKELEQLVSDDGIYKEQV LAKRLTMLDFLEDYPACEMPFERFLALLPSLKPRYYSISSSPKVHANIVSMTVGVVKA SAWSGRGEYRGVASNYLAELNTGDAAACFIRTPQSGFQMPNDPETPMIMVGPGTGIAP FRGFIQARSVLKKEGSTLGEALLYFGCRRPDHDDLYREELDQAEQDGLVTIRRCYSRV ENEPKGYVQHLLKQDTQKLMTLIEKGAHIYVCGDGSQMAPDVERTLRLAYEAEKAASQ EESAVWLQKLQDQRRYVKDVWTGM*" /label="cypB CDS" gene complement(2294468..2297632) /gene="cypB" /locus_tag="BSU_27160" /old_locus_tag="BSU27160" /label="cypB gene" downshifts complement(2294484) /Source="Nicolas_upshifts" /id="D1387" /incds=0 /nref=25 /ntot=213 /MaxReadThrough="2.3596" /MaxDrop="4.0425" /score="-9.99429269" /energy="-17.6" /TU="NA" /idTUdmin="U2091" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2295618..2295627 /Source="Nicolas_upshift_promotors" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2295641..2295660 /Source="Nicolas_upshift_promotors" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2295662 /Source="Nicolas_upshifts" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2297648..2298232) /gene="bscR" /locus_tag="BSU_27170" /old_locus_tag="BSU27170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11574077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574077; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for cypB" /protein_id="NP_390595.1" /db_xref="EnsemblGenomes-Gn:BSU27170" /db_xref="EnsemblGenomes-Tr:CAB14659" /db_xref="GOA:O08335" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="InterPro:IPR032551" /db_xref="SubtiList:BG12298" /db_xref="UniProtKB/Swiss-Prot:O08335" /translation="MISASSSKYDMIMKASVSLFTERGFDATTIPMIAERAHVGTGTI YRYFDSKETLVNVLFQESIQRFTEKLKQDVSELPVREGFHHVFCCLVQFTKESDYALF FLETKKDAHYLNHTSKKMIENLTQMLDDYFNKGKAEGVIRSLPSNVLIAIVLGAFLKI YQLVQTGDIEMDTDLITELEQCCWDAIKLHSSQK*" /label="bscR CDS" gene complement(2297648..2298232) /gene="bscR" /locus_tag="BSU_27170" /old_locus_tag="BSU27170" /label="bscR gene" CDS complement(2298455..2298997) /gene="yrhH" /locus_tag="BSU_27180" /old_locus_tag="BSU27180" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15870467; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_390596.1" /db_xref="EnsemblGenomes-Gn:BSU27180" /db_xref="EnsemblGenomes-Tr:CAB14660" /db_xref="GOA:O05400" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12297" /db_xref="UniProtKB/Swiss-Prot:O05400" /translation="MLENRLYKRSDFWKLFSRKYKLTKTIEHMMIDSIDIQENDRILE IGIGNGTVFKSITKKLKKGSLKSIDPSKRKVRQISRANRKNMGNGEVFHGYPEDIPFD DRTFNKVFSLHTVQSCTDIRLALREIYRVLQIDGRFYISIDTNTGEKEKTYIQLLKDQ HFRDLSVIRRASCLCIVAVK*" /label="yrhH CDS" gene complement(2298455..2298997) /gene="yrhH" /locus_tag="BSU_27180" /old_locus_tag="BSU27180" /label="yrhH gene" S_feature complement(2298998..2299083) /Source="Nicolas_S_feature" /locus_tag="new_2778420_2778505_c" /HighExp="T-0.40H, Salt, T0.30H, Heat, T0.0H, Etha, T-1.10H, T-1.40H, T1.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1023" promotor_-10 complement(2299081..2299096) /Source="Nicolas_upshift_promotors" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2299083) /Source="Nicolas_upshifts" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2299109..2299118) /Source="Nicolas_upshift_promotors" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2299152..2299368) /Source="Nicolas_S_feature" /locus_tag="new_2778574_2778790_c" /HighExp="S7, S8, S6, LPhT, BT, LBGstat, S5, B36, G/S, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99909999999999999" /TUshortSig="SigK, SigA" /TUshortPSig="0.999, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1024" CDS complement(2299186..2299344) /locus_tag="BSU_27185" /old_locus_tag="BSU27185" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513991.1" /translation="MMNDYQKRLPSIGHGYASMPHSFKHGYGNPFRQQRLMAMQQQRL YVFPYHWH*" /label="hypothetical protein CDS" gene complement(2299186..2299344) /locus_tag="BSU_27185" /old_locus_tag="BSU27185" /label="gene" downshifts complement(2299195) /Source="Nicolas_upshifts" /id="D1388" /incds=0 /nref=34 /ntot=184 /MaxReadThrough="3.04168" /MaxDrop="7.65849" /score="23.6695072" /energy="-11.3" /TU="U2093" /idTUdmin="U2092" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2299366..2299385) /Source="Nicolas_upshift_promotors" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2299368) /Source="Nicolas_upshifts" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2299370..2299500) /Source="Nicolas_S_feature" /locus_tag="new_2778792_2778922_c" /HighExp="S7, S8, LPhT, S6, LBGstat, B36, BT, S5, Cold, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.893648" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1025" promotor_-35 complement(2299399..2299408) /Source="Nicolas_upshift_promotors" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2299501..2299650) /gene="yrzI" /locus_tag="BSU_27190" /old_locus_tag="BSU27190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390597.1" /db_xref="EnsemblGenomes-Gn:BSU27190" /db_xref="EnsemblGenomes-Tr:CAB14661" /db_xref="InterPro:IPR012655" /db_xref="SubtiList:BG13819" /db_xref="UniProtKB/Swiss-Prot:O32027" /translation="MTINLFFLTLTIKKRFKSLEEFEREQQIEQIYDEMKESQLKHLY LTNWR*" /label="yrzI CDS" gene complement(2299501..2299650) /gene="yrzI" /locus_tag="BSU_27190" /old_locus_tag="BSU27190" /label="yrzI gene" downshifts 2299644 /Source="Nicolas_upshifts" /id="D1389" /incds=0 /nref=4 /ntot=35 /MaxReadThrough="1.96539" /MaxDrop="3.70444" /score="-6.5827622" /energy="-7.8" /TU="NA" /idTUdmin="U2089" /TUdmin=4972 /isTUend="FALSE" /label="downshifts" S_feature complement(2299651..2299741) /Source="Nicolas_S_feature" /locus_tag="new_2779073_2779163_c" /HighExp="S7, LBGstat, Cold, S6, B36, LPhT, T-0.40H, LoTm, S8, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1026" S_feature complement(2299743..2299962) /Source="Nicolas_S_feature" /locus_tag="new_2779165_2779384_c" /HighExp="B60, B36, S7, BT, LBGstat, Cold, LoTm, LPhT, S6, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52109300000000003" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1027" downshifts complement(2299786) /Source="Nicolas_upshifts" /id="D1390" /incds=0 /nref=2 /ntot=37 /MaxReadThrough="7.23426" /MaxDrop="3.6023" /score="11.9275075" /energy="-19.6" /TU="U2093,U2094" /idTUdmin="U2094" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" downshifts 2299908 /Source="Nicolas_upshifts" /id="D1391" /incds=0 /nref=16 /ntot=94 /MaxReadThrough="0.94778" /MaxDrop="4.28987" /score="-6.5827622" /energy="-7.8" /TU="NA" /idTUdmin="U2089" /TUdmin=5236 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2299941..2299960) /Source="Nicolas_upshift_promotors" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2299962) /Source="Nicolas_upshifts" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2299964..2300039) /Source="Nicolas_S_feature" /locus_tag="new_2779386_2779461_c" /HighExp="Lbexp, dia0, dia5, G150, Cold, C30, Mt0, LBGexp, dia15, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.115567" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1028" promotor_-35 complement(2299975..2299982) /Source="Nicolas_upshift_promotors" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2300040..2300840) /gene="yrhG" /locus_tag="BSU_27200" /old_locus_tag="BSU27200" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 24887098; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative formate/nitrite transporter" /protein_id="NP_390598.1" /db_xref="EnsemblGenomes-Gn:BSU27200" /db_xref="EnsemblGenomes-Tr:CAB14662" /db_xref="GOA:O05399" /db_xref="InterPro:IPR000292" /db_xref="InterPro:IPR023271" /db_xref="InterPro:IPR024002" /db_xref="SubtiList:BG12296" /db_xref="UniProtKB/Swiss-Prot:O05399" /translation="MAFRKPDEIAEAAIEAGMKKIKLPLPSLLVLGFLGGAFIALGYL LDIRVIGDLPKEWGSLSSLIGAAVFPVGLILVVLAGAELITGNMMSVAMALFSRKISV KELAINWGIVTIMNLIGALFVAYFFGHLVGLTETGPYLEKTIAVAQGKLDMSFGKVLI SAIGCNWLVCLAVWLSFGAQDAAGKILGIWFPIMAFVAIGFQHVVANMFVIPAAIFAG SFTWGQFIGNIIPAFIGNVIGGAVFVGLIYFIAYHKKDRSRKEMKQVS*" /label="yrhG CDS" gene complement(2300040..2300840) /gene="yrhG" /locus_tag="BSU_27200" /old_locus_tag="BSU27200" /label="yrhG gene" S_feature complement(2300909..2301062) /Source="Nicolas_S_feature" /locus_tag="new_2780331_2780484_c" /HighExp="Lbexp, dia0, dia5, Cold, G150, Etha, HiOs, Salt, C90, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1029" downshifts complement(2300952) /Source="Nicolas_upshifts" /id="D1392" /incds=0 /nref=1 /ntot=70 /MaxReadThrough="6.01922" /MaxDrop="3.7673" /score="23.461824" /energy="-25" /TU="U2094,U2095" /idTUdmin="U2095" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2301053..2301072) /Source="Nicolas_upshift_promotors" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="promotor_-10" upshifts complement(2301062) /Source="Nicolas_upshifts" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="upshifts" promotor_-35 complement(2301087..2301093) /Source="Nicolas_upshift_promotors" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="promotor_-35" CDS complement(2301103..2301471) /gene="yrhF" /locus_tag="BSU_27210" /old_locus_tag="BSU27210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390599.1" /db_xref="EnsemblGenomes-Gn:BSU27210" /db_xref="EnsemblGenomes-Tr:CAB14663" /db_xref="InterPro:IPR018745" /db_xref="SubtiList:BG12295" /db_xref="UniProtKB/Swiss-Prot:O05398" /translation="MSKKIHEFNDIIRKLRKELFGKGPERIHTVFVENMAVSTLYGNL SASEQFIARTPEGREMVHAARTSLIQDLYSKQTPEGMEELMGAKLVHLFSDIKIEENI AVSVFVFDRKIDEQKEALQS*" /label="yrhF CDS" gene complement(2301103..2301471) /gene="yrhF" /locus_tag="BSU_27210" /old_locus_tag="BSU27210" /label="yrhF gene" S_feature complement(2301472..2301568) /Source="Nicolas_S_feature" /locus_tag="new_2780894_2780990_c" /HighExp="T0.30H, LBGstat, T1.0H, T1.30H, G150, Lbexp, dia0, G180, M9-stat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1030" promotor_-10 complement(2301554..2301573) /Source="Nicolas_upshift_promotors" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="promotor_-10" promotor_-35 2301558..2301561 /Source="Nicolas_upshift_promotors" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2301574) /Source="Nicolas_upshifts" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="upshifts" promotor_-10 2301577..2301596 /Source="Nicolas_upshift_promotors" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2301579 /Source="Nicolas_upshifts" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="upshifts" S_feature 2301580..2301786 /Source="Nicolas_S_feature" /locus_tag="new_2781002_2781208" /HighExp="G150, Lbexp, dia0, Cold, dia5, G135, LBGstat, LBGexp, G180, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1031" promotor_-35 complement(2301589..2301593) /Source="Nicolas_upshift_promotors" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="promotor_-35" CDS 2301787..2304729 /gene="yrhE" /locus_tag="BSU_27220" /old_locus_tag="BSU27220" /EC_number="1.17.1.9" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10913079, 19114526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative formate dehydrogenase" /protein_id="NP_390600.1" /db_xref="EnsemblGenomes-Gn:BSU27220" /db_xref="EnsemblGenomes-Tr:CAB14664" /db_xref="GOA:Q795Y4" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR006478" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR019574" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG12294" /db_xref="UniProtKB/Swiss-Prot:Q795Y4" /translation="MMDVKSISVRVDGTEIQARAGATILDILNENGIEYPQICHVPEV DPIQTCDTCIVEANGKLVRSCATVAENGMSIDLSGNRVKEAQTEAMDRLLENHLLYCT VCDNNNGNCTLHNTAEMMGIEHQKYPYTPKEDPSCAVDMSHPFYRYDPNQCIACGQCV EVCQNLQVNETLSIDWERERPRVIWDEGVPINESSCVSCGQCVTVCPCNALMEKSMLG QAGFMTGIKEDVMEPMIDLVKNVEPGYGSIFAISEVEAAMRETRTKKTKTVCTFCGVG CSFEVWTKGRDILKIQPVSDAPVNAISTCVKGKFGWDFVNSKERITKPLIRKNGAFVE SSWEEALDLVASRLGSIKEQYGKGSVGFISSSKITNEENYVIQKLARQVFETNNVDNC SRYCQSPATDGLFRTVGMGGDAGTIKDIAKAGLVIIVGANPAEGHPVLATRVKRAHKL HGQKLIVADLRKNEMAERSDLFISPKQGTDQVWLMAVTKYMIDQGWHDQAFIDENVNY FEDYKETLKTYTLDYAERITGLSKENIIQIAEMIRDADGTCVLWGMGVTQNTGGSDTS AAISNLLLATGNYRRPGAGAYPLRGHNNVQGACDMGTLPGWLPGYQHITDDKARAKFE EAYGVEIDGKPGLDNIQMLHAIEEGKMKAMYLVGEDMALVDSNANHVHDILSSLDFFV VQDIFLSRTAQYADVVLPATPSLEKDGTFTNTERRVQRLYQALPTLGDAKPDWWIIQE VANRLGANWNYSHPSDIFSEMASLSPLFAKASYEVLEGWNSFLWGSFTGESTPLLYED GFNFPDKKARFALSDWTEPAAFPEEYDLHINNGRMLEHFHEGNMTNKSKGIQAKVPNV FVEISPELAQERGVCDGSLVRLVSPFGAVKLNALITDRVRKNELYLPMNSTDKESAIN FLTGPAADKRTNTPAYKQTKVRMEVLGGCETAPLPKTNPRNKKRHPQNGVEAERKWNR PGYVHLTD*" /label="yrhE CDS" gene 2301787..2304729 /gene="yrhE" /locus_tag="BSU_27220" /old_locus_tag="BSU27220" /label="yrhE gene" CDS 2304748..2305230 /gene="yrhD" /locus_tag="BSU_27230" /old_locus_tag="BSU27230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10913079" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390601.1" /db_xref="EnsemblGenomes-Gn:BSU27230" /db_xref="EnsemblGenomes-Tr:CAB14665" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG12293" /db_xref="UniProtKB/Swiss-Prot:O05396" /translation="MATPITTIKKETKTAEQIKLEKIEELKELLAENEDAVSKTMTLM NELNDLGIFDAATSMLRAKEDIAKIALGQVSREPVTNLINTMMAAGGALTKADPEFTA KLLESVMAGTEQAQSFLKEDKKVGILDLLKAMNDPDINRAVGFGLQFLKGMGKELREQ *" /label="yrhD CDS" gene 2304748..2305230 /gene="yrhD" /locus_tag="BSU_27230" /old_locus_tag="BSU27230" /label="yrhD gene" downshifts 2305210 /Source="Nicolas_upshifts" /id="D1393" /incds=0 /nref=65 /ntot=196 /MaxReadThrough="1.1227" /MaxDrop="6.19465" /score="27.8496451" /energy="-11.2" /TU="NA" /idTUdmin="U2096" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2305266..2305496) /gene="yrhC" /locus_tag="BSU_27240" /old_locus_tag="BSU27240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17056751" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390602.1" /db_xref="EnsemblGenomes-Gn:BSU27240" /db_xref="EnsemblGenomes-Tr:CAB14666" /db_xref="GOA:O05395" /db_xref="InterPro:IPR025418" /db_xref="SubtiList:BG12292" /db_xref="UniProtKB/Swiss-Prot:O05395" /translation="MNKNRMKSLKEDYKHFAFTLLAVSTFLYIGAVLPDQGLTLGQKS TMFLADCVFLAGAFFCADRSLIYKKRLEEADE*" /label="yrhC CDS" gene complement(2305266..2305496) /gene="yrhC" /locus_tag="BSU_27240" /old_locus_tag="BSU27240" /label="yrhC gene" downshifts complement(2305286) /Source="Nicolas_upshifts" /id="D1394" /incds=0 /nref=60 /ntot=210 /MaxReadThrough="0.98344" /MaxDrop="5.84379" /score="15.2557797" /energy="-11.2" /TU="NA" /idTUdmin="U2097" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2305497..2305578) /Source="Nicolas_S_feature" /locus_tag="new_2784919_2785000_c" /HighExp="dia5, dia15, BT, Diami, B36, B60, nit, dia0, MG 10, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigA" /TUshortPSig="1, 0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1032" CDS complement(2305579..2306718) /gene="mccB" /locus_tag="BSU_27250" /old_locus_tag="BSU27250" /EC_number="4.4.1.2" /EC_number="4.4.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15760717, 17056751, 18812398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15760717, 17056751, 18812398; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine gamma-lyase and homocysteine gamma-lyase for reverse transsulfuration pathway" /protein_id="NP_390603.1" /db_xref="EnsemblGenomes-Gn:BSU27250" /db_xref="EnsemblGenomes-Tr:CAB14667" /db_xref="GOA:O05394" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12291" /db_xref="UniProtKB/Swiss-Prot:O05394" /translation="MKKKTLMIHGGITGDEKTGAVSVPIYQVSTYKQPKAGQHTGYEY SRTANPTRTALEALVTELESGEAGYAFSSGMAAITAVMMLFNSGDHVVLTDDVYGGTY RVMTKVLNRLGIESTFVDTSSREEVEKAIRPNTKAIYIETPTNPLLKITDLTLMADIA KKAGVLLIVDNTFNTPYFQQPLTLGADIVLHSATKYLGGHSDVVGGLVVTASKELGEE LHFVQNSTGGVLGPQDSWLLMRGIKTLGLRMEAIDQNARKIASFLENHPAVQTLYYPG SSNHPGHELAKTQGAGFGGMISFDIGSEERVDAFLGNLKLFTIAESLGAVESLISVPA RMTHASIPRERRLELGITDGLIRISVGIEDAEDLLEDIGQALENI*" /label="mccB CDS" gene complement(2305579..2306718) /gene="mccB" /locus_tag="BSU_27250" /old_locus_tag="BSU27250" /label="mccB gene" CDS complement(2306720..2307643) /gene="mccA" /locus_tag="BSU_27260" /old_locus_tag="BSU27260" /EC_number="2.5.1.47" /EC_number="4.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15760717, 17056751, 18812398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15760717, 17056751, 18812398; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine beta-synthase for the reverse transsulfuration pathway" /protein_id="NP_390604.1" /db_xref="EnsemblGenomes-Gn:BSU27260" /db_xref="EnsemblGenomes-Tr:CAB14668" /db_xref="GOA:O05393" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG12290" /db_xref="UniProtKB/Swiss-Prot:O05393" /translation="MTVITDITELIGNTPLLRLKNFDVPEGVAVYAKLEMMNPGGSIK DRLGDMLIRDALDSGKVKPGGVIIEATAGNTGIGLALSARKYGLKAIFCVPEHFSREK QQIMQALGASIIHTPRQDGMQGAIQKAIQLETEIENSYCVLQFKNRVNPSTYYKTLGP EMWEALDGNIHTFVAGAGSGGTFAGTASFLKEKNPAVKTVIVEPVGSILNGGEPHAHK TEGIGMEFIPDYMDKSHFDEIYTVTDENAFRLVKEAAEKEGLLIGSSSGAALYAALEE AKKASAGTNIVTVFPDSSDRYISKQIYEGGI*" /label="mccA CDS" gene complement(2306720..2307643) /gene="mccA" /locus_tag="BSU_27260" /old_locus_tag="BSU27260" /label="mccA gene" downshifts complement(2307636) /Source="Nicolas_upshifts" /id="D1395" /incds=0 /nref=16 /ntot=178 /MaxReadThrough="7.13056" /MaxDrop="3.40819" /score="0.994445584" /energy="-8.7" /TU="U2097,U2098,U2099" /idTUdmin="U2102" /TUdmin=1874 /isTUend="FALSE" /label="downshifts" S_feature complement(2307644..2307707) /Source="Nicolas_S_feature" /locus_tag="new_2787066_2787129_c" /HighExp="dia5, Diami, dia15, BT, B36, S6, LBGstat, S8, dia0, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigA" /TUshortPSig="1, 0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1033" CDS complement(2307708..2308403) /gene="mtnN" /locus_tag="BSU_27270" /old_locus_tag="BSU27270" /EC_number="3.2.2.9" /EC_number="3.2.2.16" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10574451, 10939241, 15102328, 17056751, 24509311, 25849497, 25849889" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10574451, 10939241, 15102328, 17056751, 24509311, 25849497, 25849889; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioadenosine / S-adenosylhomocysteine nucleosidase" /protein_id="NP_390605.1" /db_xref="EnsemblGenomes-Gn:BSU27270" /db_xref="EnsemblGenomes-Tr:CAB14669" /db_xref="GOA:O32028" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR010049" /db_xref="InterPro:IPR035994" /db_xref="SubtiList:BG13800" /db_xref="UniProtKB/Swiss-Prot:O32028" /translation="MRLAVIGAMEEEVTILRNKLENAKTETIAHCEFTTGEYEGTEVI LLKSGIGKVNAAISTTLLLDRYKPDYVINTGSAGGFHHTLNVGDVVISTDVRHHDVDV TAFDYEYGQVPGLPAAYAADEKLISITEEAVSELDGIQVAKGTIATGDSFMNDPKRVE EVRARFSDLYAVEMEAAAVAQVCHQFKTPFVVIRALSDIAGKESHVSFDQFLEQAAVH STELVLKVIKRIH*" /label="mtnN CDS" gene complement(2307708..2308403) /gene="mtnN" /locus_tag="BSU_27270" /old_locus_tag="BSU27270" /label="mtnN gene" promotor_-10 complement(2308143..2308162) /Source="Nicolas_upshift_promotors" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2308161) /Source="Nicolas_upshifts" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2308175..2308184) /Source="Nicolas_upshift_promotors" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2308424..2309065) /gene="yrrT" /locus_tag="BSU_27280" /old_locus_tag="BSU27280" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 17056751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative AdoMet-dependent methyltransferase" /protein_id="NP_390606.1" /db_xref="EnsemblGenomes-Gn:BSU27280" /db_xref="EnsemblGenomes-Tr:CAB14670" /db_xref="GOA:O32029" /db_xref="InterPro:IPR001737" /db_xref="InterPro:IPR020598" /db_xref="InterPro:IPR023553" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13799" /db_xref="UniProtKB/Swiss-Prot:O32029" /translation="MGREFIPLFEDWAATYDQTVQGLDIQYKEAFRGYDHILDAIVRK SGTHVLEFGPGTGNLTAKLLDAGKTVFGIEPSPAMRKLASDKLSGRTEIVDGDFLTFP EPPFQADTIVSSYAFHHLTDEEKRAAIKQYGKYLHLHDKIVFADTVFENAQAYQQAID KARSQGFYQLANDLETEHYPTLDALKEMFTAEGFAVRFTQQNDFVWIMEAIKR*" /label="yrrT CDS" gene complement(2308424..2309065) /gene="yrrT" /locus_tag="BSU_27280" /old_locus_tag="BSU27280" /label="yrrT gene" promotor_-10 complement(2308632..2308651) /Source="Nicolas_upshift_promotors" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2308651) /Source="Nicolas_upshifts" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2308668..2308671) /Source="Nicolas_upshift_promotors" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2309117..2309126 /Source="Nicolas_upshift_promotors" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2309123..2309142) /Source="Nicolas_upshift_promotors" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2309129) /Source="Nicolas_upshifts" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2309139..2309158 /Source="Nicolas_upshift_promotors" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2309148..2309212 /Source="Nicolas_S_feature" /locus_tag="new_2788570_2788634" /HighExp="BT, S6, S7, S8, S5, B36, G/S, Pyr, C30, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1034" upshifts 2309148 /Source="Nicolas_upshifts" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2309158..2309161) /Source="Nicolas_upshift_promotors" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2309193..2309200 /Source="Nicolas_upshift_promotors" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2309214 /Source="Nicolas_upshifts" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2309216..2309233 /Source="Nicolas_upshift_promotors" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2309258..2309461 /gene="yrzA" /locus_tag="BSU_27290" /old_locus_tag="BSU27290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390607.1" /db_xref="EnsemblGenomes-Gn:BSU27290" /db_xref="EnsemblGenomes-Tr:CAB14671" /db_xref="InterPro:IPR019686" /db_xref="SubtiList:BG13811" /db_xref="UniProtKB/Swiss-Prot:O32030" /translation="MNFQLDLIKDKVEFFEAASLQELEKKINTQIENNKAIMLRVKSV SHQTLVAEGRILYSAVVHFSAEA*" /label="yrzA CDS" gene 2309258..2309461 /gene="yrzA" /locus_tag="BSU_27290" /old_locus_tag="BSU27290" /label="yrzA gene" downshifts 2309468 /Source="Nicolas_upshifts" /id="D1396" /incds=0 /nref=205 /ntot=257 /MaxReadThrough="1.11529" /MaxDrop="5.39095" /score="26.0850303" /energy="-14.2" /TU="NA" /idTUdmin="U2101" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(2309498..2310199) /gene="yrrS" /locus_tag="BSU_27300" /old_locus_tag="BSU27300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14679248" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390608.1" /db_xref="EnsemblGenomes-Gn:BSU27300" /db_xref="EnsemblGenomes-Tr:CAB14672" /db_xref="GOA:O32031" /db_xref="InterPro:IPR009988" /db_xref="SubtiList:BG13798" /db_xref="UniProtKB/Swiss-Prot:O32031" /translation="MSNNQSRYENRDKRRKANLVLNILIAIVSILIVVVAANLFINSP SSKDVSKDSETAQKQESPASGKTEKKSDEDIKDSKKDTSDSEKDSEKSSDSDSKKDDS SSKKDDSDSDSSSDSAGDGLKDAKVTEGGSSSDVEKTYENPDWKAVGTEQTGEHAATY DSSSQDWAEMLKAISYATGVSTDNMTVLWLGNNGSPQDAKGKILDKATGNKYQVTITW VDEKGWKPTKVEKLK*" /label="yrrS CDS" gene complement(2309498..2310199) /gene="yrrS" /locus_tag="BSU_27300" /old_locus_tag="BSU27300" /label="yrrS gene" downshifts complement(2309510) /Source="Nicolas_upshifts" /id="D1397" /incds=0 /nref=237 /ntot=265 /MaxReadThrough="1.64695" /MaxDrop="6.48551" /score="22.1367505" /energy="-14.2" /TU="NA" /idTUdmin="U2102" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2310264..2312018) /gene="pbpI" /locus_tag="BSU_27310" /old_locus_tag="BSU27310" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14679248" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679248; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein PBP4B" /protein_id="NP_390609.1" /db_xref="EnsemblGenomes-Gn:BSU27310" /db_xref="EnsemblGenomes-Tr:CAB14673" /db_xref="GOA:O32032" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG13797" /db_xref="UniProtKB/Swiss-Prot:O32032" /translation="MKISKRMKLAVIAFLIVFFLLLLRLAEIQLFFTESFSKKKINLI QESVKQRTEEVLISDGRGSFLDRNGRALTGQSEPAVVLFPFLLTQDWPIKKVADILGM SEDDLRQTLGQAKKPVILQQKKIKTLSKQSITKINSLKYPGIYGVYMENEDKPSLASH TIGSTNQDPALLRKKYPDKESLPITTEIGTTGLERTFDEFLLPEQDTKLLYHVDGKGN PLFGMDVKYTAEANTFYPLQIKTTIDQSIQKAMEEVLDEQGLKKGGAVLLDIENSSVL GIVSKPDADVSRQNTLQNYMLTPIYPGSVFKTVIAAAAIENNMVKPSQTFNCNLNLYG EPGDDKGTLSFDESFAQSCNYTFTSLAEQLMKKDSSVIEDMSEKLALTDRAGWEGKLY HETDFRQLYNEKSGVIWGDEKDKSVKKAIAQTAIGQKNVKVTPLEVANMMATIARGGE KRQVKIAEQIEYKNGTTLVTFKDQKLKGETIDKYTSQQLQKILRRVVESPSGTGRRFQ DLPYTVAGKSGTAQTGKLSKEKETLYEKWFAGYFPADKPKYALVVLHMDTPGDKALTN SVFYDIVKKVHEIEINQK*" /label="pbpI CDS" gene complement(2310264..2312018) /gene="pbpI" /locus_tag="BSU_27310" /old_locus_tag="BSU27310" /label="pbpI gene" misc_feature complement(2310292..2310311) /Source="Nicolas_upshift_promotors" /id="U2102" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.938061938061938" /psig="0.998001998001998" /xcortree=2157 /SigmaFactorBS="gttttacacatggatacaccgggagataaggctctgacaaat tcggtgtttTATGATATTGTTAAAAAAGTacacgaaattgaaatcaatcagaaataga a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2310302) /Source="Nicolas_upshifts" /id="U2102" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.938061938061938" /psig="0.998001998001998" /xcortree=2157 /SigmaFactorBS="gttttacacatggatacaccgggagataaggctctgacaaat tcggtgtttTATGATATTGTTAAAAAAGTacacgaaattgaaatcaatcagaaataga a" /listShort="yrrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2311333..2311348) /Source="Nicolas_upshift_promotors" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2311336) /Source="Nicolas_upshifts" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2311361..2311370) /Source="Nicolas_upshift_promotors" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2311564..2311582) /Source="Nicolas_upshift_promotors" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2311578) /Source="Nicolas_upshifts" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2311597..2311604 /Source="Nicolas_upshift_promotors" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2311597..2311602) /Source="Nicolas_upshift_promotors" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2311619..2311638 /Source="Nicolas_upshift_promotors" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2311624 /Source="Nicolas_upshifts" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2312072..2312545) /gene="greA" /locus_tag="BSU_27320" /old_locus_tag="BSU27320" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10910724, 16014871, 16707701, 21515770, 28976965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10910724, 16014871, 16707701, 21515770, 28976965; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription elongation factor resolving backtracking / stalling" /protein_id="NP_390610.1" /db_xref="EnsemblGenomes-Gn:BSU27320" /db_xref="EnsemblGenomes-Tr:CAB14674" /db_xref="GOA:P80240" /db_xref="InterPro:IPR001437" /db_xref="InterPro:IPR006359" /db_xref="InterPro:IPR018151" /db_xref="InterPro:IPR022691" /db_xref="InterPro:IPR023459" /db_xref="InterPro:IPR028624" /db_xref="InterPro:IPR036805" /db_xref="InterPro:IPR036953" /db_xref="SubtiList:BG19019" /db_xref="UniProtKB/Swiss-Prot:P80240" /translation="MAQEKVFPMTAEGKQKLEQELEYLKTVKRKEVVERIKIARSFGD LSENSEYDSAKEEQAFVEGRVTTLENMIRNAKIIEDDGGSNVVGLGKTVTFVELPDGD EESYTIVGSAEADPFEGKISNDSPIAKSLLGKKVDEEVTVQTPGGEMLVKIVKIS*" /label="greA CDS" gene complement(2312072..2312545) /gene="greA" /locus_tag="BSU_27320" /old_locus_tag="BSU27320" /label="greA gene" downshifts complement(2312079) /Source="Nicolas_upshifts" /id="D1398" /incds=0 /nref=130 /ntot=229 /MaxReadThrough="5.30316" /MaxDrop="4.90519" /score="34.2316821" /energy="-17" /TU="U2107" /idTUdmin="U2106" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" S_feature complement(2312546..2312678) /Source="Nicolas_S_feature" /locus_tag="new_2791968_2792100_c" /HighExp="HPh, C90, dia5, dia15, Diami, H2O2, dia0, Etha, G180, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.998, 1, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1035" promotor_-10 complement(2312660..2312679) /Source="Nicolas_upshift_promotors" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2312678) /Source="Nicolas_upshifts" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2312680..2312788) /Source="Nicolas_S_feature" /locus_tag="new_2792102_2792210_c" /HighExp="HPh, G180, G135, LBGexp, dia0, Paraq, Oxctl, G150, LPh, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1036" promotor_-35 complement(2312693..2312700) /Source="Nicolas_upshift_promotors" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2312781..2312800) /Source="Nicolas_upshift_promotors" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2312788) /Source="Nicolas_upshifts" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2312796..2313431) /gene="udk" /locus_tag="BSU_27330" /old_locus_tag="BSU27330" /EC_number="2.7.1.48" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 6208029; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uridine kinase" /protein_id="NP_390611.1" /db_xref="EnsemblGenomes-Gn:BSU27330" /db_xref="EnsemblGenomes-Tr:CAB14675" /db_xref="GOA:O32033" /db_xref="InterPro:IPR000764" /db_xref="InterPro:IPR006083" /db_xref="InterPro:IPR026008" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12696" /db_xref="UniProtKB/Swiss-Prot:O32033" /translation="MGKNPVVIGIAGGSGSGKTSVTRSIYEQFKGHSILMIQQDLYYK DQSHLPFEERLNTNYDHPLAFDNDYLIEHIQDLLNYRPIEKPIYDYKLHTRSEETVHV EPKDVIILEGILVLEDKRLRDLMDIKLYVDTDADLRIIRRIMRDINERGRSIDSVIEQ YVSVVRPMHNQFVEPTKRYADIIIPEGGQNHVAIDLMVTKIQTILEQNAIL*" /label="udk CDS" gene complement(2312796..2313431) /gene="udk" /locus_tag="BSU_27330" /old_locus_tag="BSU27330" /label="udk gene" promotor_-35 complement(2312816..2312820) /Source="Nicolas_upshift_promotors" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2312926..2312931 /Source="Nicolas_upshift_promotors" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2312947..2312965 /Source="Nicolas_upshift_promotors" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2312954 /Source="Nicolas_upshifts" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2313438..2314706) /gene="yrrO" /locus_tag="BSU_27340" /old_locus_tag="BSU27340" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase large subunit" /protein_id="NP_390612.1" /db_xref="EnsemblGenomes-Gn:BSU27340" /db_xref="EnsemblGenomes-Tr:CAB14676" /db_xref="GOA:O32034" /db_xref="InterPro:IPR001539" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR032525" /db_xref="SubtiList:BG13796" /db_xref="UniProtKB/Swiss-Prot:O32034" /translation="MTAVNDKISTIVNGKRVITKKPELLAPAGNLEKLKIAVHYGADA VFIGGQEYGLRSNADNFTIEEIAEGVEFAKKYGAKIYVTTNIFAHNENMDGLEDYLKA LGDANVAGIIVADPLIIETCRRVAPNVEVHLSTQQSLSNWKAVQFWKEEGLDRVVLAR ETSALEIREMKEKVDIEIESFIHGAMCIAYSGRCVLSNHMTARDSNRGGCCQSCRWDY DLYQTDGANAVALYGEEDAPFAMSPKDLKLIESIPKMIEMGIDSLKIEGRMKSIHYVA TVVSVYRKVIDAYCADPENFVIQKEWLEELDKCANRDTATAFFEGTPGYEEQMFGEHA KKTTYDFVGLVLNYDEDTQMVTLQQRNFFKKGDEVEFFGPEIENFTHTIETIWDEDGN ELDAARHPLQIVKFKLDKKIYPSNMMRKGK*" /label="yrrO CDS" gene complement(2313438..2314706) /gene="yrrO" /locus_tag="BSU_27340" /old_locus_tag="BSU27340" /label="yrrO gene" CDS complement(2314725..2315654) /gene="yrrN" /locus_tag="BSU_27350" /old_locus_tag="BSU27350" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase small subunit" /protein_id="NP_390613.1" /db_xref="EnsemblGenomes-Gn:BSU27350" /db_xref="EnsemblGenomes-Tr:CAB14677" /db_xref="GOA:O32035" /db_xref="InterPro:IPR001539" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG13795" /db_xref="UniProtKB/Swiss-Prot:O32035" /translation="MKKPELLVTPTSTADILPLIQAGATAFLVGEQRYGLRLAGEFSR EDVTKAVEIAHKEGAKVYVAVNAIFHNDKVGELGEYLAFLAEAGVDAAVFGDPAVLMA ARESAPDLKLHWSTETTGTNYYTCNYWGRKGAARSVLARELNMDSIVEIKENAEVEIE IQVHGMTCMFQSKRSLIGNYFEYQGKVMDIERKKKESGMFLHDKERDNKYPIFEDENG THIMSPNDVCIIDELEELIDAGIDSFKIDGVLKMPEYLIEVTKMYREAIDLCVENRDE YEAKKEDWIERIESIQPVNRKIDTGFFFKETVY*" /label="yrrN CDS" gene complement(2314725..2315654) /gene="yrrN" /locus_tag="BSU_27350" /old_locus_tag="BSU27350" /label="yrrN gene" CDS complement(2315660..2316313) /gene="yrrM" /locus_tag="BSU_27360" /old_locus_tag="BSU27360" /EC_number="2.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA O-methyltransferase" /protein_id="NP_390614.1" /db_xref="EnsemblGenomes-Gn:BSU27360" /db_xref="EnsemblGenomes-Tr:CAB14678" /db_xref="GOA:O32036" /db_xref="InterPro:IPR002935" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13794" /db_xref="UniProtKB/Swiss-Prot:O32036" /translation="MTDRYEQINDYIEALLKPRPDNVKRLEAYAEEHHVPIMEKAGME VLLQILSVKQPKKILEIGTAIGYSAIRMALELPSAEIYTIERNEKRHEEAVNNIKEFQ LDDRIHVFYGDALELADAVHVTAPYDVIFIDAAKGQYQNFFHLYEPMLSPDGVIITDN VLFKGLVAEDYSKIEPKRRRRLVAKIDEYNHWLMNHPDYQTAIIPVGDGLAISKKKR* " /label="yrrM CDS" gene complement(2315660..2316313) /gene="yrrM" /locus_tag="BSU_27360" /old_locus_tag="BSU27360" /label="yrrM gene" S_feature complement(2316314..2316418) /Source="Nicolas_S_feature" /locus_tag="new_2795736_2795840_c" /HighExp="LBGexp, G180, H2O2, G150, Paraq, Oxctl, G135, dia15, C30, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1037" promotor_-10 complement(2316400..2316419) /Source="Nicolas_upshift_promotors" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2316418) /Source="Nicolas_upshifts" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2316435..2316439) /Source="Nicolas_upshift_promotors" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2316465..2317547) /gene="yrrL" /locus_tag="BSU_27370" /old_locus_tag="BSU27370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved membrane associated protein" /protein_id="NP_390615.1" /db_xref="EnsemblGenomes-Gn:BSU27370" /db_xref="EnsemblGenomes-Tr:CAB14679" /db_xref="GOA:O34758" /db_xref="InterPro:IPR003770" /db_xref="SubtiList:BG13793" /db_xref="UniProtKB/Swiss-Prot:O34758" /translation="MYINQQKKSFFNKKRIILSSIVVLFLIIGGAFLYGKSLLEPVEK DSKTTVNINIPSGSSVSAIASILKKNDVIKSEKAFQYYVKYKGASGFQAGFYHLNKGM DLDAIIQKLTSGATGYAFQITVTEGAQLTQIAAAIADETKYSKKQVIAKLDDETFINQ LKKEFPDTVTNDVFNKNIKHPLEGYLFPATYPFNDPDTSLEDIIKAMIKQTNSYVETY KSEMKKNKVSVHKLLTMASLIEEEATEKADRHKIASVFYNRLKKKMPLQTDPTVLYAA GKHKDRVLYKDLEIDSPYNTYKNTGLTPGPIANAGMSSWEAALHPDKTDYLYFLAKSN GEVVFTKTLKEHNKAKEKYISSKNEK*" /label="yrrL CDS" gene complement(2316465..2317547) /gene="yrrL" /locus_tag="BSU_27370" /old_locus_tag="BSU27370" /label="yrrL gene" downshifts complement(2316499) /Source="Nicolas_upshifts" /id="D1399" /incds=0 /nref=21 /ntot=144 /MaxReadThrough="3.5258" /MaxDrop="3.97301" /score="10.5327118" /energy="-11" /TU="U2110" /idTUdmin="U2111" /TUdmin=1173 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2317563..2317582) /Source="Nicolas_upshift_promotors" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2317583) /Source="Nicolas_upshifts" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2317597..2317600) /Source="Nicolas_upshift_promotors" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2317673) /Source="Nicolas_upshifts" /id="D1400" /incds=0 /nref=260 /ntot=268 /MaxReadThrough="2.55298" /MaxDrop="6.9121" /score="36.0941054" /energy="-15" /TU="NA" /idTUdmin="U2111" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2317678..2317959) /gene="yrzB" /locus_tag="BSU_27380" /old_locus_tag="BSU27380" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_390616.1" /db_xref="EnsemblGenomes-Gn:BSU27380" /db_xref="EnsemblGenomes-Tr:CAB14680" /db_xref="InterPro:IPR009711" /db_xref="SubtiList:BG13812" /db_xref="UniProtKB/Swiss-Prot:O34828" /translation="MEHGEKNITIVDDQGNEQLCEVLFTFENEEFGKSYVLYYPIESK DDEEVEILASSFTPNEDGENGELFPIETDEEWDMIEETLNTFLADEDEE*" /label="yrzB CDS" gene complement(2317678..2317959) /gene="yrzB" /locus_tag="BSU_27380" /old_locus_tag="BSU27380" /label="yrzB gene" downshifts complement(2317738) /Source="Nicolas_upshifts" /id="D1401" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.68915" /MaxDrop="5.19246" /score="36.0941054" /energy="-15" /TU="U2111,U2113,U2114,U2115" /idTUdmin="U2111" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2317977..2318393) /gene="rimF" /locus_tag="BSU_27390" /old_locus_tag="BSU27390" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15044829, 14512736, 16021622, 22720735, 23251031, 25545592; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pre-16S ribosomal RNA maturation enzyme" /protein_id="NP_390617.1" /db_xref="EnsemblGenomes-Gn:BSU27390" /db_xref="EnsemblGenomes-Tr:CAB14681" /db_xref="GOA:O34634" /db_xref="InterPro:IPR005227" /db_xref="InterPro:IPR006641" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR037027" /db_xref="PDB:1VHX" /db_xref="SubtiList:BG13792" /db_xref="UniProtKB/Swiss-Prot:O34634" /translation="MRILGLDLGTKTLGVALSDEMGWTAQGIETIKINEAEGDYGLSR LSELIKDYTIDKIVLGFPKNMNGTVGPRGEASQTFAKVLETTYNVPVVLWDERLTTMA AEKMLIAADVSRQKRKKVIDKMAAVMILQGYLDSLN*" /label="rimF CDS" gene complement(2317977..2318393) /gene="rimF" /locus_tag="BSU_27390" /old_locus_tag="BSU27390" /label="rimF gene" promotor_-10 complement(2318225..2318243) /Source="Nicolas_upshift_promotors" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2318244) /Source="Nicolas_upshifts" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2318259..2318264) /Source="Nicolas_upshift_promotors" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2318401..2318667) /gene="yrzL" /locus_tag="BSU_27400" /old_locus_tag="BSU27400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_054589.1" /db_xref="EnsemblGenomes-Gn:BSU27400" /db_xref="EnsemblGenomes-Tr:CAE01464" /db_xref="InterPro:IPR009309" /db_xref="SubtiList:BG14184" /db_xref="UniProtKB/Swiss-Prot:Q7WY61" /translation="MSSFDKTMKFNFSDDSAETNVNEVLITVYDALQEKGYNPINQIV GYLLSGDPAYIPRHRDARNLIRKLERDELIEELVKSYLEQHKEA*" /label="yrzL CDS" gene complement(2318401..2318667) /gene="yrzL" /locus_tag="BSU_27400" /old_locus_tag="BSU27400" /label="yrzL gene" promotor_-35 2318555..2318563 /Source="Nicolas_upshift_promotors" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2318578..2318597 /Source="Nicolas_upshift_promotors" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2318586..2319775 /Source="Nicolas_S_feature" /locus_tag="new_2798008_2799197" /HighExp="S6, C30, C90, S8, S7, Gly, G135, Fru, G180, M/G" /AntisenseName="alaS" /AntisenseCor="-0.27843994691040502" /AntisenseRegPval="-5.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S1038" upshifts 2318586 /Source="Nicolas_upshifts" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2318668..2318728) /Source="Nicolas_S_feature" /locus_tag="new_2798090_2798150_c" /HighExp="LBGtran, LBGexp, G135, C90, G150, G180, LBGstat, Oxctl, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigA" /TUshortPSig="0.994, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1039" promotor_-10 complement(2318722..2318741) /Source="Nicolas_upshift_promotors" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2318728) /Source="Nicolas_upshifts" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2318752..2321388) /gene="alaS" /locus_tag="BSU_27410" /old_locus_tag="BSU27410" /EC_number="6.1.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12554667, 12682299, 17329819, 22720735, 25918376; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alanyl-tRNA synthetase" /protein_id="NP_390618.1" /db_xref="EnsemblGenomes-Gn:BSU27410" /db_xref="EnsemblGenomes-Tr:CAB14682" /db_xref="GOA:O34526" /db_xref="InterPro:IPR002318" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018162" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR018164" /db_xref="InterPro:IPR018165" /db_xref="InterPro:IPR023033" /db_xref="SubtiList:BG12563" /db_xref="UniProtKB/Swiss-Prot:O34526" /translation="MKHLTSAEVRQMFLDFFKEKGHAVEPSASLVPHEDPSLLWINSG VATLKKYFDGRVVPENPRIVNAQKAIRTNDIENVGKTARHHTFFEMLGNFSIGDYFKE EAITWAWEFLTSDKWIGFDKELLSVTVHPEDEEAYEFWAKKIGIPEERIIRLEGNFWD IGEGPSGPNTEIFYDRGEAYGNDPEDPELYPGGENDRYLEVWNLVFSEFNHNPDGTYT PLPKKNIDTGMGLERMVSVIQNVPTNFDTDLFVPIIKATESISGETYGKDNVKDTAFK VIADHIRTVAFAVSDGALPSNEGRGYVLRRLLRRAVRYAKTINIHRPFMFDLVPVVAE IMADFYPEVKEKADFIAKVIKTEEERFHETLNEGLAILSEMIKKEKDKGSSVISGADV FKLYDTYGFPVELTEEYAEDENMTVDHEGFEEEMNQQRERARNARQDVGSMQVQGGAL RDVTVESTFVGYSQTKADANIIVLLQDGQLIEEAHEGESVQIILDETPFYAESGGQIG DKGYLRSEQAVVRIKDVQKAPNGQHVHEGVVESGTVQKGLHVTAEVEDHMRSGVIKNH TATHLLHQALKDVLGTHVNQAGSLVTENRLRFDFSHFGQVTKEELEQIERIVNEKIWA SIPVSIDLKPIAEAKEMGAMALFGEKYGDIVRVVQVGDYSLELCGGCHVRNTAEIGLF KIVSESGIGAGTRRIEAVTGQGAYVEMNSQISVLKQTADELKTNIKEVPKRVAALQAE LKDAQRENESLLAKLGNVEAGAILSKVKEVDGVNVLAAKVNAKDMNHLRTMVDELKAK LGSAVIVLGAVQNDKVNISAGVTKDLIEKGLHAGKLVKQAAEVCGGGGGGRPDMAQAG GKQPEKLEEALASVEDWVKSVL*" /label="alaS CDS" gene complement(2318752..2321388) /gene="alaS" /locus_tag="BSU_27410" /old_locus_tag="BSU27410" /label="alaS gene" promotor_-35 complement(2318755..2318762) /Source="Nicolas_upshift_promotors" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2321154..2321172) /Source="Nicolas_upshift_promotors" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2321170) /Source="Nicolas_upshifts" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2321186..2321193) /Source="Nicolas_upshift_promotors" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2321389..2321467) /Source="Nicolas_S_feature" /locus_tag="new_2800811_2800889_c" /HighExp="G150, LBGexp, G135, G180, Oxctl, LBGtran, Lbexp, Paraq, dia15, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1040" misc_RNA complement(2321468..2321675) /gene="tboA" /locus_tag="BSU_misc_RNA_40" /product="T-box riboswitch specific of alanine tRNA" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboA RNA" gene complement(2321468..2321675) /gene="tboA" /locus_tag="BSU_misc_RNA_40" /label="tboA gene" promotor_-10 complement(2321683..2321702) /Source="Nicolas_upshift_promotors" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2321698) /Source="Nicolas_upshifts" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2321717..2321724) /Source="Nicolas_upshift_promotors" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2321719..2322780) /gene="yrrI" /locus_tag="BSU_27420" /old_locus_tag="BSU27420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_390619.1" /db_xref="EnsemblGenomes-Gn:BSU27420" /db_xref="EnsemblGenomes-Tr:CAB14683" /db_xref="GOA:O34472" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13791" /db_xref="UniProtKB/Swiss-Prot:O34472" /translation="MLQKPVQLLLWVAICLLVLLTVYVFFMLDMLWSPFWLVIKTIFI PLIISIFISYLLLPVTEWLHGKGLPRTLSILVIYVLFFGGIGWALYKGVPVLIVQLTD LSENIPMFAETYNGLLLHVHNHTDDWPDGMHHRIDKMIRQTEAFFAGTIEGAISGIRN VLDYFLIAATIPFLVFYMVKDIELMKKTVWYLTPKSWRKRGSAFLRDVDDSLGDYIRG QLLVCLILGVIAGISFWVFGLPYPLILGLISGVTNVIPYFGPFIGAVPALLIAMTISV KAVLVVVITVFILQFMEGNILSPFIVGRSLKMHPVVIMLALLAGGELAGIVGMILAVP ATAVLKVMMIHFLRMRTEH*" /label="yrrI CDS" gene complement(2321719..2322780) /gene="yrrI" /locus_tag="BSU_27420" /old_locus_tag="BSU27420" /label="yrrI gene" promotor_-35 2322689..2322694 /Source="Nicolas_upshift_promotors" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2322700..2322935 /Source="Nicolas_S_feature" /locus_tag="new_2802122_2802357" /HighExp="S5, S6, S4, S8, S3, S7, LoTm, BT, M9-stat, T5.0H" /AntisenseName="yrrI" /AntisenseCor="0.71790030040923003" /AntisenseRegPval="-43.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1041" upshifts 2322701 /Source="Nicolas_upshifts" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2322710..2322728 /Source="Nicolas_upshift_promotors" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2322797..2322808) /Source="Nicolas_upshift_promotors" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2322798) /Source="Nicolas_upshifts" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2322822..2322828) /Source="Nicolas_upshift_promotors" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2322936..2323664 /gene="glnQ" /locus_tag="BSU_27430" /old_locus_tag="BSU27430" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (ATP-binding protein)" /protein_id="NP_390620.1" /db_xref="EnsemblGenomes-Gn:BSU27430" /db_xref="EnsemblGenomes-Tr:CAB14684" /db_xref="GOA:O34677" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11485" /db_xref="UniProtKB/Swiss-Prot:O34677" /translation="MITFQNVNKHYGDFHVLKQINLQIEKGEVVVIIGPSGSGKSTLL RCINRLESINEGVLTVNGTAINDRKTDINQVRQNIGMVFQHFHLYPHKTVLQNIMLAP VKVLRQSPEQAKETARYYLEKVGIPDKADAYPSQLSGGQQQRVAIARGLAMKPEVMLF DEPTSALDPEMIGEVLDVMKTLAKEGMTMVVVTHEMGFAKEVADRIVFIDEGKILEEA VPAEFYANPKEERARLFLSRILNH*" /label="glnQ CDS" gene 2322936..2323664 /gene="glnQ" /locus_tag="BSU_27430" /old_locus_tag="BSU27430" /label="glnQ gene" downshifts complement(2323392) /Source="Nicolas_upshifts" /id="D1402" /incds=1 /nref=1 /ntot=9 /MaxReadThrough="1.29649" /MaxDrop="3.29152" /score="-3.35464926" /energy="-5.4" /TU="NA" /idTUdmin="U2117" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" CDS 2323686..2324507 /gene="glnH" /locus_tag="BSU_27440" /old_locus_tag="BSU27440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (glutamine-binding lipoprotein)" /protein_id="NP_390621.1" /db_xref="EnsemblGenomes-Gn:BSU27440" /db_xref="EnsemblGenomes-Tr:CAB14685" /db_xref="GOA:O34563" /db_xref="InterPro:IPR001320" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11486" /db_xref="UniProtKB/Swiss-Prot:O34563" /translation="MKKIFSLALISLFAVILLAACGSKGSNGEASKESKKDTLAAIKD NDKIVFGVKTDTRLFGLKNPSSGEIEGFDIDIAKQIAKDILGDEKKAQFKEVTSKTRI PMLQNGDIDAIVATMTITEERKKEVDFSDVYFEAGQSLLVKKGSKIKSVENLGKGSKV LAVKGSTSSQNIREKAPEASVLEFENYAEAFTALKSGQGDALTTDNAILYGMADENKN YQLTGKPFTDEPYGIAVKKGQSALAKEINASLKKMKSDGRYDEIYKKWIKEDPAE*" /label="glnH CDS" gene 2323686..2324507 /gene="glnH" /locus_tag="BSU_27440" /old_locus_tag="BSU27440" /label="glnH gene" CDS 2324568..2325218 /gene="glnM" /locus_tag="BSU_27450" /old_locus_tag="BSU27450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (permease)" /protein_id="NP_390622.1" /db_xref="EnsemblGenomes-Gn:BSU27450" /db_xref="EnsemblGenomes-Tr:CAB14686" /db_xref="GOA:O34671" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11487" /db_xref="UniProtKB/Swiss-Prot:O34671" /translation="MNVSILFDNFSMYMDGFYHTLLASVIALAGSFVLGVAVAVMRIT VFKPLQWLGTAYVEFIRNIPLLLITFVFYFGLPNAGLRLDGFQAGTVALTIYTSAFIA EAIRAGIQSVSKGQMEAARSSGFTYSQAMLHIILPQAIKIVIPPLGNQFLNLVKNSSI LGVVAGLDLMYQADLVSSSTLVVFDVYIFVALFYLVLTIPLSIGVNYLEKRLEKSY*" /label="glnM CDS" gene 2324568..2325218 /gene="glnM" /locus_tag="BSU_27450" /old_locus_tag="BSU27450" /label="glnM gene" CDS 2325235..2325891 /gene="glnP" /locus_tag="BSU_27460" /old_locus_tag="BSU27460" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (permease)" /protein_id="NP_390623.1" /db_xref="EnsemblGenomes-Gn:BSU27460" /db_xref="EnsemblGenomes-Tr:CAB14687" /db_xref="GOA:O34606" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11488" /db_xref="UniProtKB/Swiss-Prot:O34606" /translation="MDFIGAYSQEHLAFLWDGFLVTLYVAFISIILSFFFGLIAGTLR YAKVPVLSQLIAVLVETIRNLPLLLIIFFTFFALPEIGIKLEITAAAITALTIFESAM LSEIIRSGLKSIDKGQIEAARSSGLSYTQTLFFIVMPQALRRMVPPIVSQFISLLKDT SLAVVIALPELIHNAQIINGQSADGSYFFPIFLLAALMYFAVNYSLSLAARRLEVRQT *" /label="glnP CDS" gene 2325235..2325891 /gene="glnP" /locus_tag="BSU_27460" /old_locus_tag="BSU27460" /label="glnP gene" downshifts 2325890 /Source="Nicolas_upshifts" /id="D1403" /incds=0 /nref=15 /ntot=32 /MaxReadThrough="2.21558" /MaxDrop="6.08472" /score="5.38937989" /energy="-11.7" /TU="NA" /idTUdmin="U2116" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2325926..2326057) /gene="yrzQ" /locus_tag="BSU_27468" /old_locus_tag="BSU27468" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097766.1" /db_xref="EnsemblGenomes-Gn:BSU27468" /db_xref="EnsemblGenomes-Tr:CAX52672" /db_xref="InterPro:IPR025029" /db_xref="UniProtKB/Swiss-Prot:C0H461" /translation="MNRTMTSLLAMGAGALVYRMATQSDMLNNRSMKRMRRRITKMF* " /label="yrzQ CDS" gene complement(2325926..2326057) /gene="yrzQ" /locus_tag="BSU_27468" /old_locus_tag="BSU27468" /label="yrzQ gene" downshifts complement(2325944) /Source="Nicolas_upshifts" /id="D1404" /incds=0 /nref=50 /ntot=77 /MaxReadThrough="1.58565" /MaxDrop="8.21989" /score="5.69801689" /energy="-11.7" /TU="NA" /idTUdmin="U2118" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2326079..2326270) /gene="yrzR" /locus_tag="BSU_27469" /old_locus_tag="BSU27469" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097767.1" /db_xref="EnsemblGenomes-Gn:BSU27469" /db_xref="EnsemblGenomes-Tr:CAX52673" /db_xref="UniProtKB/Swiss-Prot:C0H462" /translation="MLICPNCKSKDIGKIGVNQYYCWGCFIELTVAKGKIATHQVEED GTLSSLDDLFSEDERSINF*" /label="yrzR CDS" gene complement(2326079..2326270) /gene="yrzR" /locus_tag="BSU_27469" /old_locus_tag="BSU27469" /label="yrzR gene" CDS complement(2326282..2326806) /gene="yrrD" /locus_tag="BSU_27470" /old_locus_tag="BSU27470" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390624.1" /db_xref="EnsemblGenomes-Gn:BSU27470" /db_xref="EnsemblGenomes-Tr:CAB14688" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG13790" /db_xref="UniProtKB/Swiss-Prot:O34402" /translation="MSLRRKAKPKPVQQKVVDHTLRTCHEVEGFPVYSERTSSYLGTI SDICFSLKGDCLGFILAQKRFLHHHHALLRACDISSIFDDRILASVSSEQLLPLPKSC FTYEQMKMKLVKSQEGDILGMLEDVYFCLDRGIIVAYELSDGFFSDLAGSKRQIQRAD SLVEVRKDEIVLNG*" /label="yrrD CDS" gene complement(2326282..2326806) /gene="yrrD" /locus_tag="BSU_27470" /old_locus_tag="BSU27470" /label="yrrD gene" upshifts complement(2326393) /Source="Nicolas_upshifts" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2326397..2326408) /Source="Nicolas_upshift_promotors" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2326423..2326429) /Source="Nicolas_upshift_promotors" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2326777..2326788) /Source="Nicolas_upshift_promotors" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2326783) /Source="Nicolas_upshifts" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2326803..2326809) /Source="Nicolas_upshift_promotors" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2326864..2329260) /gene="recDB" /locus_tag="BSU_27480" /old_locus_tag="BSU27480" /EC_number="3.1.11.5" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3537961, 11557815, 21170359, 22720735, 24443534, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3537961, 11557815, 21170359, 22720735, 24443534, 28527403; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="5'-3' helicase associated to SSB; exonuclease V" /protein_id="NP_390625.1" /db_xref="EnsemblGenomes-Gn:BSU27480" /db_xref="EnsemblGenomes-Tr:CAB14689" /db_xref="GOA:O34481" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR006345" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027785" /db_xref="InterPro:IPR029493" /db_xref="SubtiList:BG13789" /db_xref="UniProtKB/Swiss-Prot:O34481" /translation="MQQHPDQLKLEEEPYLKGTVNTVIYHNDTNLYTVLKVKVTETSE AIEDKAVSVTGYFPALQEEETYTFYGKIVTHPKFGLQFQAEHFKKEIPTTKEGIIQYL SSDLFEGIGKKTAEEIVKKLGDSAINKILADASVLYDVPRLSKKKADTLAGALQRHQG LEQIMISLNQFGFGPQLSMKIYQAYESETLEKIQENPYQLVKDVEGIGFGKADELGSR MGLSGNHPERVKAAILYTLETTCLSEGHTYIETEQLIIDTQSLLNQSAREGQRITEMD AANAIIALGENKDIVIEDGRCYFPSLFYAEQNVAKRVKHIASQTEYENQFPESEFLLA LGELEERMDVQYAPSQKEAIQKALSSPMLLLTGGPGTGKTTVIRGIVELYGELHGVSL DPSAYKKDEAFPIVLAAPTGRAAKRMSESTGLPAVTIHRLLGWNGAEGFTHTEDQPIE GKLLIIDEASMLDIWLANHLFKAIPDHIQIIIVGDEDQLPSVGPGQVLRDLLASQVIP TVRLTDIYRQAEGSSIVELAHQMKNGLLPNNLTAPTKDRSFIRCGGSQIKEVVEKVVA NALKKGYTAKDIQVLAPMYRGKAGINELNVMLQDILNPPKEKRRELKFGDVVYRTGDK ILQLVNQPENNVFNGDIGEITSIFYAKENTEKEDMAVVSFDGNEMTFTKKDFNQFTHA YCCSIHKSQGSEFPIVVLPVVKGYYRMLRRNLLYTAITRAKKFLILCGEEEALEWGVK NNDATVRQTSLKNRLSVQVEEMDAELEALQKELPFSVHDANIGMEGITPFDFMKEEQQ *" /label="recDB CDS" gene complement(2326864..2329260) /gene="recDB" /locus_tag="BSU_27480" /old_locus_tag="BSU27480" /label="recDB gene" downshifts complement(2326890) /Source="Nicolas_upshifts" /id="D1405" /incds=0 /nref=32 /ntot=211 /MaxReadThrough="2.07603" /MaxDrop="3.57113" /score="41.0323102" /energy="-10.8" /TU="NA" /idTUdmin="U2121" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2327110..2327116 /Source="Nicolas_upshift_promotors" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2327124 /Source="Nicolas_upshifts" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2327131..2327142 /Source="Nicolas_upshift_promotors" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2327144..2327493 /Source="Nicolas_S_feature" /locus_tag="new_2806566_2806915" /HighExp="S8, S5, S6, S7, S4, C30, nit, ferm, G135, T5.0H" /AntisenseName="yrrC" /AntisenseCor="-0.46935785055870999" /AntisenseRegPval="-15.4" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1042" downshifts complement(2327245) /Source="Nicolas_upshifts" /id="D1406" /incds=1 /nref=16 /ntot=163 /MaxReadThrough="4.93428" /MaxDrop="2.86437" /score="41.0323102" /energy="-10.8" /TU="U2121,U2122" /idTUdmin="U2121" /TUdmin="-355" /isTUend="FALSE" /label="downshifts" CDS complement(2329285..2329905) /gene="yrrB" /locus_tag="BSU_27490" /old_locus_tag="BSU27490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11777911, 12594026, 18180259; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative tetratricopeptide repeat family protein" /protein_id="NP_390626.1" /db_xref="EnsemblGenomes-Gn:BSU27490" /db_xref="EnsemblGenomes-Tr:CAB14690" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR013105" /db_xref="InterPro:IPR019734" /db_xref="PDB:2Q7F" /db_xref="SubtiList:BG13788" /db_xref="UniProtKB/Swiss-Prot:O34452" /translation="MQEGDYEKAAEAFTKAIEENKEDAIPYINFANLLSSVNELERAL AFYDKALELDSSAATAYYGAGNVYVVKEMYKEAKDMFEKALRAGMENGDLFYMLGTVL VKLEQPKLALPYLQRAVELNENDTEARFQFGMCLANEGMLDEALSQFAAVTEQDPGHA DAFYNAGVTYAYKENREKALEMLDKAIDIQPDHMLALHAKKLIDPS*" /label="yrrB CDS" gene complement(2329285..2329905) /gene="yrrB" /locus_tag="BSU_27490" /old_locus_tag="BSU27490" /label="yrrB gene" CDS complement(2329991..2331106) /gene="mnmA" /locus_tag="BSU_27500" /old_locus_tag="BSU27500" /EC_number="2.8.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12549933, 12756333, 9811540, 15044829, 17580114, 22720735, 25825430" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12549933, 12756333, 9811540, 15044829, 17580114, 22720735, 25825430; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-specific 2-thiouridylase" /protein_id="NP_390627.3" /db_xref="EnsemblGenomes-Gn:BSU27500" /db_xref="EnsemblGenomes-Tr:CAB14691" /db_xref="GOA:O35020" /db_xref="InterPro:IPR004506" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR023382" /db_xref="SubtiList:BG13787" /db_xref="UniProtKB/Swiss-Prot:O35020" /translation="MEKRPEDTRVVVGMSGGVDSSVAALLLKEQGYDVIGIFMKNWDD TDENGFCTATEDYEDVIRVCNQIGIPYYAVNFEKQYYEKVFQYFLDEYKAGRTPNPDV LCNKEIKFKAFLEHALSLGADYLATGHYARVDRSGGKVRMLRGIDENKDQTYFLNQLT EDTLSKVMFPIGELQKSRVREIAKEAELATATKKDSTGICFIGERNFKTFLSQYLPAQ PGDMMTMDGEVKGRHDGLMYYTIGQRHGLGIGGSGEPWFAVGKDLEKNILYVDQGFHN PLLYSDKITATNISWVRSDIMKGEEISCTAKFRYRQEDHKVTVRMTGEGEAEVIFDEQ VRAVTPGQAVVFYDGEECLGGGTIDDVYKDGTKLWYV*" /label="mnmA CDS" gene complement(2329991..2331106) /gene="mnmA" /locus_tag="BSU_27500" /old_locus_tag="BSU27500" /label="mnmA gene" downshifts complement(2329992) /Source="Nicolas_upshifts" /id="D1407" /incds=0 /nref=2 /ntot=69 /MaxReadThrough="6.45399" /MaxDrop="4.31641" /score="2.49091848" /energy="-7.8" /TU="U2121,U2122" /idTUdmin="U2121" /TUdmin="-3102" /isTUend="FALSE" /label="downshifts" CDS complement(2331137..2332276) /gene="iscSA" /locus_tag="BSU_27510" /old_locus_tag="BSU27510" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7496536, 10930739, 12682299, 17064282, 25825430" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7496536, 10930739, 12682299, 17064282, 25825430; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase involved in U34 tRNA thiolation" /protein_id="NP_390629.2" /db_xref="EnsemblGenomes-Gn:BSU27510" /db_xref="EnsemblGenomes-Tr:CAB14693" /db_xref="GOA:O34599" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG13809" /db_xref="UniProtKB/Swiss-Prot:O34599" /translation="MERIYLDHAATSPMDERVLEQMIPHFSGSFGNPSSIHSFGRESR KWVDEARAQIAAEIGAAEQEIIFTSGGTEADNLAIMGTALARKDLGRHIITTKIEHHA VLHTCEKLEGDGFDITYLDVDQNGRVSAKQVKEALRDDTILVTVMYGNNEVGTVQPIE EIGELLKEHKAYFHTDAVQAFGLLPIDVKNSHIDLLSVSGHKLNGPKGTGFLYASKDV KLSPLLFGGEQERKRRAGTENVPGIVGLKEAIKLSSEERDEKNEKYQSFKAIFADTLR DAGVAFEVNGDKEHSLPHVLNLYFPGVSVEALLVNLDMAGVAVSSGSACTAGSVLPSH VLTAMFGEESDRLTSSIRISFGLGNTAEQVKTAAKHVADVVKRLT*" /label="iscSA CDS" gene complement(2331137..2332276) /gene="iscSA" /locus_tag="BSU_27510" /old_locus_tag="BSU27510" /label="iscSA gene" promotor_-10 complement(2331843..2331862) /Source="Nicolas_upshift_promotors" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2331855) /Source="Nicolas_upshifts" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2331876..2331883) /Source="Nicolas_upshift_promotors" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2332295..2332711) /gene="cymR" /locus_tag="BSU_27520" /old_locus_tag="BSU27520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15668000, 16109943, 16513748, 17056751, 18974048, 19508281, 21624051" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15668000, 16109943, 16513748, 17056751, 18974048, 19508281, 21624051; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of cysteine biosynthesis" /protein_id="NP_390630.2" /db_xref="EnsemblGenomes-Gn:BSU27520" /db_xref="EnsemblGenomes-Tr:CAB14694" /db_xref="GOA:O34527" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2Y75" /db_xref="SubtiList:BG13813" /db_xref="UniProtKB/Swiss-Prot:O34527" /translation="MKISTKGRYGLTIMIELAKKHGEGPTSLKSIAQTNNLSEHYLEQ LVSPLRNAGLVKSIRGAYGGYVLGSEPDAITAGDIIRVLEGPISPVEVLEDEEPAKRE LWIRIRDAVKEVLDSTTLEDLASYTDGEQEAYMFYI*" /label="cymR CDS" gene complement(2332295..2332711) /gene="cymR" /locus_tag="BSU_27520" /old_locus_tag="BSU27520" /label="cymR gene" S_feature complement(2332712..2332809) /Source="Nicolas_S_feature" /locus_tag="new_2812134_2812231_c" /HighExp="Cold, T3.0H, G135, LBGexp, G180, G150, Salt, Lbexp, H2O2, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1043" promotor_-10 complement(2332794..2332813) /Source="Nicolas_upshift_promotors" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2332809) /Source="Nicolas_upshifts" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2332829..2332832) /Source="Nicolas_upshift_promotors" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2332857..2332864 /Source="Nicolas_upshift_promotors" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2332878..2332897 /Source="Nicolas_upshift_promotors" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2332886 /Source="Nicolas_upshifts" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="upshifts" CDS 2332914..2334179 /gene="rarA" /locus_tag="BSU_27530" /old_locus_tag="BSU27530" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15743409, 17641684, 21170359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743409, 17641684, 21170359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-dependent ATPase active at replication forks" /protein_id="NP_390631.1" /db_xref="EnsemblGenomes-Gn:BSU27530" /db_xref="EnsemblGenomes-Tr:CAB14695" /db_xref="GOA:O34528" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008824" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR021886" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032423" /db_xref="SubtiList:BG13808" /db_xref="UniProtKB/Swiss-Prot:O34528" /translation="MKPLAYRMRPTKIEDIIGQQHLVAEDKIIGRMVQAKHLSSMILY GPPGIGKTSIATAIAGSTSIAFRKLNAVINNKKDMEIVAQEAKMSGQVILILDEVHRL DKGKQDFLLPYLENGMIILIGATTANPYHAINPAIRSRTQIFELEPLTPELIKQALER ALHDEHRGLGTYSVSIDDQAMEHFAHGCGGDVRSALNALELAVLSTKESADGEIHITL ETAEECLQKKSFSHDKDGDAHYDVLSAFQKSIRGSDANAALHYLARLIEAGDLESIAR RLLVIAYEDIGLASPQAGPRVLNAIQTAERVGFPEARIPLANAVIELCLSPKSNSAIL AIDEALADIRAGKIGDVPKHLKDAHYKGAQELGRGIDYKYPHNYDNGWVEQQYLPDPL KNKQYYKPKQTGKFESALKQVYDKLMKRK*" /label="rarA CDS" gene 2332914..2334179 /gene="rarA" /locus_tag="BSU_27530" /old_locus_tag="BSU27530" /label="rarA gene" downshifts 2334178 /Source="Nicolas_upshifts" /id="D1408" /incds=0 /nref=24 /ntot=228 /MaxReadThrough="1.09429" /MaxDrop="4.5261" /score="14.6665846" /energy="-12" /TU="NA" /idTUdmin="U2123" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2334221..2334985) /gene="tcdA" /locus_tag="BSU_27540" /old_locus_tag="BSU27540" /EC_number="6.1.-.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12177353, 20097860, 23242255, 27913733, 28671653; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA threonylcarbamoyladenosine dehydratase (t(6)A37 dehydratase)" /protein_id="NP_390632.3" /db_xref="EnsemblGenomes-Gn:BSU27540" /db_xref="EnsemblGenomes-Tr:CAB14713" /db_xref="GOA:O32037" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG13807" /db_xref="UniProtKB/Swiss-Prot:O32037" /translation="MLHQFSRNELAIGKEGLETLKNSTVAVLGVGGVGSFAAEALARS GVGRILLVDKDDVDITNVNRQLHALLSTVGQPKVDLMKARIADINPECEVIALKMFYT EETYEQFFDYGLDYVIDASDTICYKIHLMKECLKRDIPLISSMGAANKTDPTRFQIAD ISKTHTDPIAKVVRTKLRKEGIKKGVQVIFSDESPIVIREDVRKEVGNDEAKIRKAKM PPSSNAFVPSVAGLIMGGHVVMDLLKDIEIKRVKDK*" /label="tcdA CDS" gene complement(2334221..2334985) /gene="tcdA" /locus_tag="BSU_27540" /old_locus_tag="BSU27540" /label="tcdA gene" downshifts complement(2334239) /Source="Nicolas_upshifts" /id="D1409" /incds=0 /nref=246 /ntot=264 /MaxReadThrough="2.35294" /MaxDrop="7.20309" /score="44.7253801" /energy="-12" /TU="NA" /idTUdmin="U2125" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA complement(2335069..2335269) /gene="ssrSB" /locus_tag="BSU_misc_RNA_41" /product="6Sb RNA" /experiment="publication(s) with functional evidences, PMID:12177353, 15793584, 15811922, 25576829, 26873600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12177353, 15793584, 15811922, 25576829, 26873600; Product type n: RNA" /label="ssrSB RNA" gene complement(2335069..2335269) /gene="ssrSB" /locus_tag="BSU_misc_RNA_41" /label="ssrSB gene" downshifts complement(2335087) /Source="Nicolas_upshifts" /id="D1410" /incds=0 /nref=81 /ntot=303 /MaxReadThrough="7.44881" /MaxDrop="6.73892" /score="44.7253801" /energy="-12" /TU="U2125,U2127" /idTUdmin="U2125" /TUdmin="-848" /isTUend="FALSE" /label="downshifts" upshifts 2335256 /Source="Nicolas_upshifts" /id="U2124" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.425574425574426" /psig="0.143856143856144" /xcortree=714 /SigmaFactorBS="gcgggctcccaaatcaaaaaaatgttcggtcaaaactaggtg tacaactaacacatcaggaCTTTATTTAActtgtcaaaatcatatcacagacgatttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2335257..2335266 /Source="Nicolas_upshift_promotors" /id="U2124" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.425574425574426" /psig="0.143856143856144" /xcortree=714 /SigmaFactorBS="gcgggctcccaaatcaaaaaaatgttcggtcaaaactaggtg tacaactaacacatcaggaCTTTATTTAActtgtcaaaatcatatcacagacgatttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2335267..2335286) /Source="Nicolas_upshift_promotors" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2335278) /Source="Nicolas_upshifts" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2335299..2335306) /Source="Nicolas_upshift_promotors" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2335321..2337099) /gene="aspS" /locus_tag="BSU_27550" /old_locus_tag="BSU27550" /EC_number="6.1.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12177353, 26804570" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12177353, 26804570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartyl-tRNA synthetase, promiscuous (also recognizes tRNAasn)" /protein_id="NP_390633.1" /db_xref="EnsemblGenomes-Gn:BSU27550" /db_xref="EnsemblGenomes-Tr:CAB14714" /db_xref="GOA:O32038" /db_xref="InterPro:IPR002312" /db_xref="InterPro:IPR004115" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004524" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029351" /db_xref="SubtiList:BG12572" /db_xref="UniProtKB/Swiss-Prot:O32038" /translation="MFGRTYYCGDITEKAIGESVTLKGWVQKRRDLGGLIFIDLRDRT GIVQVVFNPDVSKEALAIAEGIRNEYVLDIQGKVVAREEGTVNPNLKTGAIEIHADGV NVLNAAKTPPFAISDQAEEVSEDVRLKHRYLDLRRPAMFQTMQLRHNVTKAVRSFLDE NGFLDIETPILTGSTPEGARDYLVPSRVHEGEFYALPQSPQLFKQLLMVSGIERYYQI ARCFRDEDLRADRQPEFTQIDIEMSFMSQEDIMSLAEEMMAKVMRETKGEELQLPLPR MTYDEAMNKYGSDKPDTRFDMLLTDVSDIVKDTEFKVFSSAVANGGVVKAINVKGGAG DYSRKDIDALGAFAANYGAKGLAWVKVEADGVKGPIAKFFDEEKQSKLIEALDAAEGD LLLFGADQFEVVAASLGALRLKLGKERGLIDEKLFNFLWVIDWPLLEHDPEEGRFYAA HHPFTMPVREDLELIETAPEDMKAQAYDLVLNGYELGGGSIRIFEKDIQEKMFALLGF SPEEAAEQFGFLLEAFEYGAPPHGGIALGLDRLVMLLAGRTNLRDTIAFPKTASASCL MTEAPGEVSDAQLDELHLSIKKKVKN*" /label="aspS CDS" gene complement(2335321..2337099) /gene="aspS" /locus_tag="BSU_27550" /old_locus_tag="BSU27550" /label="aspS gene" CDS complement(2337113..2338387) /gene="hisS" /locus_tag="BSU_27560" /old_locus_tag="BSU27560" /EC_number="6.1.1.21" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 28321488; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="histidyl-tRNA synthetase" /protein_id="NP_390634.1" /db_xref="EnsemblGenomes-Gn:BSU27560" /db_xref="EnsemblGenomes-Tr:CAB14715" /db_xref="GOA:O32039" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR004516" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR015807" /db_xref="InterPro:IPR033656" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG12605" /db_xref="UniProtKB/Swiss-Prot:O32039" /translation="MGYNIPRGTQDILPGESDRWQFVEQIMRDTCRTYQYKEIRTPIF EHTELFARGVGESTDIVQKEMYTFEDRKGRSLTLRPEGTAAAVRAFNENKLFANPVQP TKLYYVGPMFRYERPQTGRYRQFYQFGIEAIGSKDPAIDAEVMALAMSIYEKAGLENV KLVINSLGDQDSRKSYREALVKHFEPRIEEFCSDCQSRLHTNPLRILDCKKDRDHELM KSAPSILTYLNEESAAYFEKVKQYLNDLGISYEIDPNLVRGLDYYNHTAFEIMSNAEG FGAITTLAGGGRYDGLVEQIGGPEAPGIGFAMSIERLLAAIDAEKRELPVDKGIDCYI VTLGEKAKDYSVSLVYKLREAGISSEIDYENKKMKGQFKTADRLKARFIAILGEDELA QNKINVKDAQTGEQIEVALDEFIHVMKANQKG*" /label="hisS CDS" gene complement(2337113..2338387) /gene="hisS" /locus_tag="BSU_27560" /old_locus_tag="BSU27560" /label="hisS gene" misc_RNA complement(2338477..2338709) /gene="tboH" /locus_tag="BSU_misc_RNA_42" /product="T-box riboswitch controlling synthesis of histidine and aspartate tRNA ligases" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.3: Control" /label="tboH RNA" gene complement(2338477..2338709) /gene="tboH" /locus_tag="BSU_misc_RNA_42" /label="tboH gene" downshifts complement(2338507) /Source="Nicolas_upshifts" /id="D1411" /incds=0 /nref=71 /ntot=180 /MaxReadThrough="7.0761" /MaxDrop="5.61082" /score="40.6097692" /energy="-23.7" /TU="U2127" /idTUdmin="U2128" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2338719..2338722 /Source="Nicolas_upshift_promotors" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2338733..2338752) /Source="Nicolas_upshift_promotors" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2338737..2338756 /Source="Nicolas_upshift_promotors" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2338739..2339023 /Source="Nicolas_S_feature" /locus_tag="new_2818161_2818445" /HighExp="H2O2, G135, G180, C30, G150, Paraq, Oxctl, dia15, LBGstat, LBGexp" /AntisenseName="yrzK" /AntisenseCor="-0.27832941694878799" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1044" upshifts 2338739 /Source="Nicolas_upshifts" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2338752) /Source="Nicolas_upshifts" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2338767..2338774) /Source="Nicolas_upshift_promotors" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2338769..2338939) /gene="yrzK" /locus_tag="BSU_27570" /old_locus_tag="BSU27570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390635.1" /db_xref="EnsemblGenomes-Gn:BSU27570" /db_xref="EnsemblGenomes-Tr:CAB14716" /db_xref="InterPro:IPR035378" /db_xref="SubtiList:BG13820" /db_xref="UniProtKB/Swiss-Prot:O32040" /translation="MKYHPKMGRAFHDGEANLHYSDHADPDTTGYLTETASEFGLMSK EAALRKNNRNKA*" /label="yrzK CDS" gene complement(2338769..2338939) /gene="yrzK" /locus_tag="BSU_27570" /old_locus_tag="BSU27570" /label="yrzK gene" promotor_-10 complement(2338970..2338981) /Source="Nicolas_upshift_promotors" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="promotor_-10" upshifts complement(2338987) /Source="Nicolas_upshifts" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="upshifts" promotor_-35 complement(2338996..2339002) /Source="Nicolas_upshift_promotors" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="promotor_-35" promotor_-35 2338999..2339006 /Source="Nicolas_upshift_promotors" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2339020..2339038 /Source="Nicolas_upshift_promotors" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2339025 /Source="Nicolas_upshifts" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2339072..2340628 /gene="yrvJ" /locus_tag="BSU_27580" /old_locus_tag="BSU27580" /EC_number="3.5.1.28" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetylmuramoyl-L-alanine amidase, family 3" /protein_id="NP_390636.1" /db_xref="EnsemblGenomes-Gn:BSU27580" /db_xref="EnsemblGenomes-Tr:CAB14717" /db_xref="GOA:O32041" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR003646" /db_xref="InterPro:IPR017293" /db_xref="SubtiList:BG13806" /db_xref="UniProtKB/Swiss-Prot:O32041" /translation="MNKKYFVLIVCIIFTSALFPTFSSVTAAQGEAVIATDEMNVRSG PGLSYGITAEVKKGERYPILKEDGDWVQIQLGSGEKGWVVSWLITKEDQASTSSSGSS DTVTSTDPDLRMRSGPGTSYEVIGKFPQGSQASVIDKDSGWIKISYHSATGWVSSEYV TSGGSSSASDESDQTEDSGASTTGTVGVSSLNVRASASHDAAIITKLDRGTKLTVLNE KNGWAHIEVNGLKGWVASHYLLTSSVPADDSANAGSSSSAKKAYIMYGGTNLRSDAST SASIVERAAKGDSYTITGSKGSWYEIKLDNGQTAYVANWVVQTSKSAEEAGEPPVSDS PSGNGSLNNKTIIVDPGHGGKDSGTIGYSGKFEKNLTIKTAKLLASKLRSAGADVYVT RQDDTFVSLQSRVSTSHYRNADAFISIHYDSYADTSTRGSTAYYYSPAKDQELASDVH SEVVKRSSIPDRGVLFGDYYVLRENRQPAMLYELGYVSHPQEEAIVHSNSYQEKVTDG IESGLEKYFQ*" /label="yrvJ CDS" gene 2339072..2340628 /gene="yrvJ" /locus_tag="BSU_27580" /old_locus_tag="BSU27580" /label="yrvJ gene" downshifts 2340607 /Source="Nicolas_upshifts" /id="D1412" /incds=0 /nref=199 /ntot=249 /MaxReadThrough="2.10072" /MaxDrop="7.40599" /score="44.9570925" /energy="-9.9" /TU="U2126" /idTUdmin="U2129" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2340655..2341053) /gene="dtd" /locus_tag="BSU_27590" /old_locus_tag="BSU27590" /EC_number="3.1.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15292242, 15525705, 16844682, 18700836, 28362257; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gly-tRNA(Ala) deacylase / D-Tyr-tRNATyr deacylase" /protein_id="NP_390637.2" /db_xref="EnsemblGenomes-Gn:BSU27590" /db_xref="EnsemblGenomes-Tr:CAB14718" /db_xref="GOA:O32042" /db_xref="InterPro:IPR003732" /db_xref="InterPro:IPR023509" /db_xref="SubtiList:BG13805" /db_xref="UniProtKB/Swiss-Prot:O32042" /translation="MDEEVVGQIGQGLMVLVGITHDDTEDDAAYLADKVVNLRIFDDS EGKMNLSLVDIGGEILSVSQFTLYGDTKKGRRPNYMNAAKPDKALGLYEKWNDLLREK GIKVETGTFGAMMDVQLTNSGPVTLIMDSK*" /label="dtd CDS" gene complement(2340655..2341053) /gene="dtd" /locus_tag="BSU_27590" /old_locus_tag="BSU27590" /label="dtd gene" downshifts complement(2340663) /Source="Nicolas_upshifts" /id="D1413" /incds=0 /nref=152 /ntot=267 /MaxReadThrough="2.01735" /MaxDrop="9.47739" /score="37.3693259" /energy="-9.9" /TU="NA" /idTUdmin="U2130" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2341107..2343311) /gene="rsh" /locus_tag="BSU_27600" /old_locus_tag="BSU27600" /EC_number="2.7.6.5" /EC_number="3.1.7.2" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:6248722, 9383190, 11545276, 12081964, 12372825, 13129942, 15066282, 17183219, 18067544, 18996989, 26460002" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6248722, 9383190, 11545276, 12081964, 12372825, 13129942, 15066282, 17183219, 18067544, 18996989, 26460002; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="GTP pyrophosphokinase (RelA/SpoT)" /protein_id="NP_390638.2" /db_xref="EnsemblGenomes-Gn:BSU27600" /db_xref="EnsemblGenomes-Tr:CAB14719" /db_xref="GOA:O54408" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004811" /db_xref="InterPro:IPR007685" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR033655" /db_xref="SubtiList:BG12665" /db_xref="UniProtKB/Swiss-Prot:O54408" /translation="MANEQVLTAEQVIDKARSYLSDEHIAFVEKAYLYAEDAHREQYR KSGEPYIIHPIQVAGILVDLEMDPSTIAGGFLHDVVEDTDVTLDDLKEAFSEEVAMLV DGVTKLGKIKYKSQEEQQAENHRKMFVAMAQDIRVILIKLADRLHNMRTLKHLPQEKQ RRISNETLEIFAPLAHRLGISKIKWELEDTALRYLNPQQYYRIVNLMKKKRAERELYV DEVVNEVKKRVEEVNIKADFSGRPKHIYSIYRKMVLQNKQFNEIYDLLAVRILVNSIK DCYAVLGIIHTCWKPMPGRFKDYIAMPKPNMYQSLHTTVIGPKGDPLEVQIRTFEMHE IAEYGVAAHWAYKEGKAANEGATFEKKLSWFREILEFQNESTDAEEFMESLKIDLFSD MVYVFTPKGDVIELPSGSVPIDFSYRIHSEIGNKTIGAKVNGKMVTLDHKLRTGDIVE ILTSKHSYGPSQDWVKLAQTSQAKHKIRQFFKKQRREENVEKGRELVEKEIKNLDFEL KDVLTPENIQKVADKFNFSNEEDMYAAVGYNGITALQVANRLTEKERKQRDQEEQEKI VQEVTGEPKPYPQGRKREAGVRVKGIDNLLVRLSKCCNPVPGDDIVGFITKGRGVSVH REDCPNVKTNEAQERLIPVEWEHESQVQKRKEYNVEIEILGYDRRGLLNEVLQAVNET KTNISSVSGKSDRNKVATIHMAIFIQNINHLHKVVERIKQIRDIYSVRRVMN*" /label="rsh CDS" gene complement(2341107..2343311) /gene="rsh" /locus_tag="BSU_27600" /old_locus_tag="BSU27600" /label="rsh gene" promotor_-10 complement(2343340..2343359) /Source="Nicolas_upshift_promotors" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2343347) /Source="Nicolas_upshifts" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2343349..2343439) /Source="Nicolas_S_feature" /locus_tag="new_2822771_2822861_c" /HighExp="Cold, G135, G180, G150, H2O2, Paraq, Oxctl, C30, LBGexp, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigB" /TUshortPSig="0.951, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 1" /label="S1045" promotor_-35 complement(2343374..2343381) /Source="Nicolas_upshift_promotors" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2343403 /Source="Nicolas_upshifts" /id="D1414" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="1.75679" /MaxDrop="3.54336" /score="0.486890657" /energy="-12.7" /TU="NA" /idTUdmin="U2126" /TUdmin=2772 /isTUend="FALSE" /label="downshifts" CDS complement(2343479..2343991) /gene="apt" /locus_tag="BSU_27610" /old_locus_tag="BSU27610" /EC_number="2.4.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 9383190, 15629952" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 9383190, 15629952; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenine phosphoribosyltransferase" /protein_id="NP_390639.1" /db_xref="EnsemblGenomes-Gn:BSU27610" /db_xref="EnsemblGenomes-Tr:CAB14720" /db_xref="GOA:O34443" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005764" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG12568" /db_xref="UniProtKB/Swiss-Prot:O34443" /translation="MDLKQYVTIVPDYPKEGVQFKDITTLMDKGDVYRYATDQIVEYA KEKQIDLVVGPEARGFIIGCPVAYALGVGFAPVRKEGKLPREVIKVDYGLEYGKDVLT IHKDAIKPGQRVLITDDLLATGGTIEATIKLVEELGGVVAGIAFLIELSYLDGRNKLE DYDILTLMKY*" /label="apt CDS" gene complement(2343479..2343991) /gene="apt" /locus_tag="BSU_27610" /old_locus_tag="BSU27610" /label="apt gene" downshifts complement(2343484) /Source="Nicolas_upshifts" /id="D1415" /incds=0 /nref=39 /ntot=228 /MaxReadThrough="5.36411" /MaxDrop="4.05036" /score="2.83935873" /energy="-6.8" /TU="U2131,U2132,U2133" /idTUdmin="U2131" /TUdmin="-115" /isTUend="FALSE" /label="downshifts" CDS complement(2343997..2346357) /gene="recJ" /locus_tag="BSU_27620" /old_locus_tag="BSU27620" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:21087930, 21170359, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21087930, 21170359, 26001966; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="single-strand DNA-specific exonuclease" /protein_id="NP_390640.1" /db_xref="EnsemblGenomes-Gn:BSU27620" /db_xref="EnsemblGenomes-Tr:CAB14721" /db_xref="GOA:O32044" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR004610" /db_xref="InterPro:IPR018779" /db_xref="SubtiList:BG13804" /db_xref="UniProtKB/Swiss-Prot:O32044" /translation="MLASKMRWEIQRPDQDKVKSLTEQLHITPLVASLLVKRGFDTAE SARLFLHTKDADFYDPFEMKGMKEAADRIKQAISQQEKIMIYGDYDADGVTSTSVMLH TLQKLSAQVDFYIPDRFKEGYGPNEQAFRSIKERGFSLIITVDTGIAAVHEAKVAKEL GLDVIITDHHEPGPELPDVRAIVHPKQPGCTYPFKELAGVGVAFKLAHALLGELPDEL LDLAAIGTIADLVPLHDENRLIATLGLERLRRTNRLGLKELIKLSGGDIGEANEETVG FQLAPRLNAVGRIEQADPAVHLLMSEDSFEAEELAAEIDQLNKERQKMVSKMTDEAIE MVEQQGLDQTAIVVAKAGWNPGVVGIVASKLVDRFYRPAIVLGIDEEKGIAKGSARSI RGFNLFESLSECRDILPHFGGHPMAAGMTLKAEDVPDLRSRLNEIADNTLTEEDFIPV QEVDLVCGVEDITVESIAEMNMLSPFGMLNPKPHVLVENAVLEDVRKIGANKTHVKMT IRNESSQLDCVGFNKGELQEGIVPGSRISIVGEMSINEWNNRKKPQLMIKDAAVSEWQ LFDLRGKRTWEDTVSALPSAKRAIVSFKEDSTTLLQTEDLRREVHVISSKDQAKAFDL DGAYIVLLDPPPSLDMLARLLEGKAPERIYFIFLNHEDHFLSTFPARDHFKWYYAFLL KRGAFDVKKHGSELAKHKGWSVETINFMTKVFFDLGFVKIENGVLSVVSGAKKRDLTD SQTYQAKQQLMELDQKLNYSSAEELKEWLNKLMKQDSEAYESTRRT*" /label="recJ CDS" gene complement(2343997..2346357) /gene="recJ" /locus_tag="BSU_27620" /old_locus_tag="BSU27620" /label="recJ gene" promotor_-10 complement(2344461..2344480) /Source="Nicolas_upshift_promotors" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="promotor_-10" upshifts complement(2344469) /Source="Nicolas_upshifts" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="upshifts" promotor_-35 complement(2344494..2344503) /Source="Nicolas_upshift_promotors" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="promotor_-35" promotor_-10 complement(2346371..2346390) /Source="Nicolas_upshift_promotors" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2346382) /Source="Nicolas_upshifts" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2346405..2346411) /Source="Nicolas_upshift_promotors" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2346424..2346747) /gene="yrvD" /locus_tag="BSU_27630" /old_locus_tag="BSU27630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390641.1" /db_xref="EnsemblGenomes-Gn:BSU27630" /db_xref="EnsemblGenomes-Tr:CAB14722" /db_xref="GOA:O32045" /db_xref="InterPro:IPR010445" /db_xref="SubtiList:BG13803" /db_xref="UniProtKB/Swiss-Prot:O32045" /translation="MNKQWTIIFALIFTLIVAIFAVINVRSVEVDYLFGRSEWPLILV ILGSVLMGALIVFSVGIFQVMKLKREIKTLRKENRTAIHKQEDTHLADQTDTQDASAM IEKKD*" /label="yrvD CDS" gene complement(2346424..2346747) /gene="yrvD" /locus_tag="BSU_27630" /old_locus_tag="BSU27630" /label="yrvD gene" promotor_-10 complement(2346768..2346786) /Source="Nicolas_upshift_promotors" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="promotor_-10" upshifts complement(2346779) /Source="Nicolas_upshifts" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="upshifts" promotor_-35 complement(2346801..2346807) /Source="Nicolas_upshift_promotors" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="promotor_-35" CDS complement(2346823..2347320) /gene="yrvC" /locus_tag="BSU_27640" /old_locus_tag="BSU27640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative potassium transport accessory component" /protein_id="NP_390642.1" /db_xref="EnsemblGenomes-Gn:BSU27640" /db_xref="EnsemblGenomes-Tr:CAB14723" /db_xref="GOA:O32046" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR026278" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG13802" /db_xref="UniProtKB/Swiss-Prot:O32046" /translation="MRVRESELPGIGQKVEMITRNRDKISIIIHHDGRRELYYFDEND HEECVASVQFDDAEARQMSAILGGMAYKPKALEQVESALDDLIIEWCKAEAGAPAIHQ TIGDLNVGQEYHVTVIAIVKKNQDKQLNPSSETVIDEGDTLVISGEGTGLKRLIREKL TAKGA*" /label="yrvC CDS" gene complement(2346823..2347320) /gene="yrvC" /locus_tag="BSU_27640" /old_locus_tag="BSU27640" /label="yrvC gene" S_feature complement(2347321..2347396) /Source="Nicolas_S_feature" /locus_tag="new_2826743_2826818_c" /HighExp="Oxctl, HiOs, G180, LBGexp, Paraq, G150, G135, H2O2, MG-0.2, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1046" promotor_-10 complement(2347390..2347409) /Source="Nicolas_upshift_promotors" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="promotor_-10" upshifts complement(2347396) /Source="Nicolas_upshifts" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="upshifts" promotor_-35 complement(2347423..2347430) /Source="Nicolas_upshift_promotors" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="promotor_-35" CDS complement(2347478..2349691) /gene="secDF" /locus_tag="BSU_27650" /old_locus_tag="BSU27650" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9694879, 15941986, 15995216, 16517687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9694879, 15941986, 15995216, 16517687; Product type t: transporter" /codon_start=1 /transl_table=11 /product="protein-export membrane protein" /protein_id="NP_390643.1" /db_xref="EnsemblGenomes-Gn:BSU27650" /db_xref="EnsemblGenomes-Tr:CAB14724" /db_xref="GOA:O32047" /db_xref="InterPro:IPR005665" /db_xref="InterPro:IPR005791" /db_xref="InterPro:IPR022645" /db_xref="InterPro:IPR022646" /db_xref="InterPro:IPR022813" /db_xref="SubtiList:BG12672" /db_xref="UniProtKB/Swiss-Prot:O32047" /translation="MKKGRLIAFFLFVLLIGTGLGYFTKPAANNITLGLDLQGGFEVL YDVQPVKKGDKITKDVLVSTVEALNRRANVLGVSEPNIQIEGNNRIRVQLAGVTNQNR AREILATEAQLSFRDANDKELLNGADLVENGAKQTYDSTTNEPIVTIKLKDADKFGEV TKKVMKMAPNNQLVIWLDYDKGDSFKKEVQKEHPKFVSAPNVSQELNTTDVKIEGHFT AQEAKDLASILNAGALPVKLTEKYSTSVGAQFGQQALHDTVFAGIVGIAIIFLFMLFY YRLPGLIAVITLSVYIYITLQIFDWMNAVLTLPGIAALILGVGMAVDANIITYERIKE ELKLGKSVRSAFRSGNRRSFATIFDANITTIIAAVVLFIFGTSSVKGFATMLILSILT SFITAVFLSRFLLALLVESRWLDRKKGWFGVNKKHIMDIQDTDENTEPHTPFQKWDFT SKRKYFFIFSSAVTVAGIIILLVFRLNLGIDFASGARIEVQSDHKLTTEQVEKDFESL GMDPDTVVLSGEKSNIGVARFVGVPDKETIAKVKTYFKDKYGSDPNVSTVSPTVGKEL ARNALYAVAIASIGIIIYVSIRFEYKMAIAAIASLLYDAFFIVTFFSITRLEVDVTFI AAILTIIGYSINDTIVTFDRVREHMKKRKPKTFADLNHIVNLSLQQTFTRSINTVLTV VIVVVTLLIFGASSITNFSIALLVGLLTGVYSSLYIAAQIWLAWKGRELKKDSAQ*" /label="secDF CDS" gene complement(2347478..2349691) /gene="secDF" /locus_tag="BSU_27650" /old_locus_tag="BSU27650" /label="secDF gene" downshifts complement(2347483) /Source="Nicolas_upshifts" /id="D1416" /incds=0 /nref=174 /ntot=249 /MaxReadThrough="4.49738" /MaxDrop="5.0013" /score="29.1843057" /energy="-17.8" /TU="U2137" /idTUdmin="U2137" /TUdmin="-1100" /isTUend="FALSE" /label="downshifts" promotor_-35 2349250..2349255 /Source="Nicolas_upshift_promotors" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2349269..2349288 /Source="Nicolas_upshift_promotors" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2349277 /Source="Nicolas_upshifts" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2349730..2350026) /gene="comN" /locus_tag="BSU_27660" /old_locus_tag="BSU27660" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19028902, 27059541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19028902, 27059541; Product type r: regulator" /codon_start=1 /transl_table=11 /product="post-transcriptional regulator" /protein_id="NP_390644.1" /db_xref="EnsemblGenomes-Gn:BSU27660" /db_xref="EnsemblGenomes-Tr:CAB14726" /db_xref="GOA:O32049" /db_xref="InterPro:IPR025716" /db_xref="SubtiList:BG13814" /db_xref="UniProtKB/Swiss-Prot:O32049" /translation="MEKHPADLYKDHVRPFLYSKLEEFKILGYDDVELESLWSYLTDK KWKKKTELSIYELASDILSVKIGEFMNYATVESFKTSNWLGSEEGQEALEELLR*" /label="comN CDS" gene complement(2349730..2350026) /gene="comN" /locus_tag="BSU_27660" /old_locus_tag="BSU27660" /label="comN gene" downshifts 2349937 /Source="Nicolas_upshifts" /id="D1417" /incds=1 /nref=1 /ntot=66 /MaxReadThrough="1.36122" /MaxDrop="2.33158" /score="-9.07145122" /energy="-8.4" /TU="NA" /idTUdmin="U2136" /TUdmin="-2508" /isTUend="FALSE" /label="downshifts" S_feature complement(2350027..2350105) /Source="Nicolas_S_feature" /locus_tag="new_2829449_2829527_c" /HighExp="LBGtran, Lbtran, C90, M40t45, HiOs, Lbexp, Cold, M0t45, UNK1, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigH" /TUlongPSig=1 /label="S1047" promotor_-35 2350067..2350072 /Source="Nicolas_upshift_promotors" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="promotor_-35" promotor_-10 2350089..2350107 /Source="Nicolas_upshift_promotors" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="promotor_-10" promotor_-10 complement(2350091..2350110) /Source="Nicolas_upshift_promotors" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="promotor_-10" upshifts 2350091 /Source="Nicolas_upshifts" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="upshifts" upshifts complement(2350105) /Source="Nicolas_upshifts" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="upshifts" S_feature complement(2350107..2351025) /Source="Nicolas_S_feature" /locus_tag="new_2829529_2830447_c" /HighExp="S2, M9-stat, Lbstat, BC, T2.0H, T3.0H, T2.30H, T3.30H, Cold, M0t90" /AntisenseName="spoVB" /AntisenseCor="-8.5173616652496897E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1048" promotor_-35 complement(2350125..2350128) /Source="Nicolas_upshift_promotors" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="promotor_-35" CDS 2350142..2351698 /gene="spoVB" /locus_tag="BSU_27670" /old_locus_tag="BSU27670" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1744050, 15292147, 15849754, 16850406, 17714441, 19648239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1744050, 15292147, 15849754, 16850406, 17714441, 19648239; Product type t : transporter" /codon_start=1 /transl_table=11 /product="involved in spore cortex synthesis (stage V sporulation); translocase with flippase function for peptidoglycan synthesis" /protein_id="NP_390645.1" /db_xref="EnsemblGenomes-Gn:BSU27670" /db_xref="EnsemblGenomes-Tr:CAB14727" /db_xref="GOA:Q00758" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR014249" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG10778" /db_xref="UniProtKB/Swiss-Prot:Q00758" /translation="MAKQTFLKGTLILIAAGMVTRMLGFVNRVVIARFIGEEGVGLYM MAAPTFFLATTLTQFGLPVAISKLVAEASARGDHQKTKNILVMSLTITGVLSLIFTPL FLFFAPVMAETMLTDKRTLYPLLAITPVVPIIAISSVLRGYFQGKQNMNPLAMSQVLE QVVRISLVAVCTTIFLPYGIEYAAAGAMLSSVAGELASLLYLFVCFKYKKTIKIRKHF LQSIKNGKQTFTQLMSVSLPTTGSRFIGNLSWFFEPIVVAQSLAIAGVATVAATKQYG ELTGFAMTLLTLPSFITYSLSTALVPAISEGMEQKKLQVVEYRLEQAMRLCLLSGGIS VVILFVFADELMRVMYGSSGAAVFIKVMAPFFLLYYFQGPLQAVLQALNLAGAAMMNS LIGALVKTGLIFVLATRPSLGIMGAALAIVTGMVLVTLLHAATVSKVLPISIKIKEYA LSFAVIVICGFISSAIKQYISFGASEAVNLAGWIAASAAIYMILLLVFRLIKKDELRR IPIIGRLIIR*" /label="spoVB CDS" gene 2350142..2351698 /gene="spoVB" /locus_tag="BSU_27670" /old_locus_tag="BSU27670" /label="spoVB gene" promotor_-10 complement(2351011..2351029) /Source="Nicolas_upshift_promotors" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="promotor_-10" upshifts complement(2351025) /Source="Nicolas_upshifts" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="upshifts" promotor_-35 complement(2351041..2351049) /Source="Nicolas_upshift_promotors" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="promotor_-35" S_feature 2351699..2352463 /Source="Nicolas_S_feature" /locus_tag="new_2831121_2831885" /HighExp="S3, BT, S4, LoTm, S7, S8, T5.0H, T4.0H, M9-stat, T3.30H" /AntisenseName="yrbG" /AntisenseCor="0.65629957843767395" /AntisenseRegPval="-33.799999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1049" CDS complement(2351702..2352358) /gene="yrbG" /locus_tag="BSU_27680" /old_locus_tag="BSU27680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390646.1" /db_xref="EnsemblGenomes-Gn:BSU27680" /db_xref="EnsemblGenomes-Tr:CAB14728" /db_xref="GOA:O32050" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG13786" /db_xref="UniProtKB/Swiss-Prot:O32050" /translation="MEELLTIAFRTVVLYFVILVIFRFMGKREIGELSILDLVVFIMM AEIAVLAIENVDDHLFHTILPMLVLMIIQVTLAYFSLKNRKVRQLLDGKPTIIIKYGK IDEEAMKSQRYNFDDLMVQLRENSIDRVADVSFAILEPSGKLTIVKKENSGEHRQLEM PLIIDGFIQTENLSRISKDRKWLLESLQKHGYTNPSDISFCSFTDGEIYIDEKDGHRT *" /label="yrbG CDS" gene complement(2351702..2352358) /gene="yrbG" /locus_tag="BSU_27680" /old_locus_tag="BSU27680" /label="yrbG gene" promotor_-10 complement(2352377..2352388) /Source="Nicolas_upshift_promotors" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2352389) /Source="Nicolas_upshifts" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2352402..2352408) /Source="Nicolas_upshift_promotors" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2352441..2352446 /Source="Nicolas_upshift_promotors" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2352462..2352480 /Source="Nicolas_upshift_promotors" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2352465 /Source="Nicolas_upshifts" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="upshifts" CDS 2352493..2352945 /gene="yrzE" /locus_tag="BSU_27690" /old_locus_tag="BSU27690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390647.1" /db_xref="EnsemblGenomes-Gn:BSU27690" /db_xref="EnsemblGenomes-Tr:CAB14729" /db_xref="GOA:O32051" /db_xref="InterPro:IPR023804" /db_xref="SubtiList:BG13815" /db_xref="UniProtKB/Swiss-Prot:O32051" /translation="MSDGFEQKEQKPFNTGREETIMEETKQVGKGILYGLIAIFSAML LTSLAVSLLLTATSLEESSFNWLITAISFLSLFIGGFISGGKGKERGWMIGALTALSF SLIILLFQYLGFGKTFTAEQLIFHLGFLGVCMLGGIFGVNMRGNRSST*" /label="yrzE CDS" gene 2352493..2352945 /gene="yrzE" /locus_tag="BSU_27690" /old_locus_tag="BSU27690" /label="yrzE gene" downshifts 2352929 /Source="Nicolas_upshifts" /id="D1418" /incds=0 /nref=39 /ntot=61 /MaxReadThrough="1.45569" /MaxDrop="7.7199" /score="41.7975947" /energy="-15" /TU="NA" /idTUdmin="U2140" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2352984) /Source="Nicolas_upshifts" /id="D1419" /incds=0 /nref=188 /ntot=281 /MaxReadThrough="2.20451" /MaxDrop="7.91954" /score="33.5938356" /energy="-15" /TU="NA" /idTUdmin="U2141" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2353002..2353268) /gene="yrbF" /locus_tag="BSU_27700" /old_locus_tag="BSU27700" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10974125, 16166550, 21235483, 26790414; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the preprotein translocase" /protein_id="NP_390648.2" /db_xref="EnsemblGenomes-Gn:BSU27700" /db_xref="EnsemblGenomes-Tr:CAB14730" /db_xref="GOA:O32052" /db_xref="InterPro:IPR003849" /db_xref="SubtiList:BG13785" /db_xref="UniProtKB/Swiss-Prot:O32052" /translation="MTGTLGTLVPIILMFAVLYFLLIRPQQKQQKAVRQMQEELKKGD SVVTIGGLHGTVDSIDESKVVIKTGDNTRLTFDRRAIREVSAAE*" /label="yrbF CDS" gene complement(2353002..2353268) /gene="yrbF" /locus_tag="BSU_27700" /old_locus_tag="BSU27700" /label="yrbF gene" CDS complement(2353305..2354450) /gene="tgt" /locus_tag="BSU_27710" /old_locus_tag="BSU27710" /EC_number="2.4.2.29" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12123838, 14660578, 16199558, 16206323; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-guanine transglycosylase" /protein_id="NP_390649.1" /db_xref="EnsemblGenomes-Gn:BSU27710" /db_xref="EnsemblGenomes-Tr:CAB14731" /db_xref="GOA:O32053" /db_xref="InterPro:IPR002616" /db_xref="InterPro:IPR004803" /db_xref="InterPro:IPR036511" /db_xref="SubtiList:BG12686" /db_xref="UniProtKB/Swiss-Prot:O32053" /translation="MAEQPIRYEFIKECKQTGARLGKVHTPHGSFETPVFMPVGTLAT VKTMSPEELKAMDAGIILSNTYHLWLRPGQDIVKEAGGLHKFMNWDRAILTDSGGFQV FSLSKFRNIEEEGVHFRNHLNGDKLFLSPEKAMEIQNALGSDIMMAFDECPPYPAEYD YMKRSVERTSRWAERCLNAHNRQDEQGLFGIVQGGEYEDLRTQSAKDLISLDFPGYAI GGLSVGEPKDVMNRVLEFTTPLLPKDKPRYLMGVGSPDALIDGAIRGVDMFDCVLPTR IARNGTVFTAEGRLNMKNAKFERDFRPIDEECDCYTCKNYTRAYIRHLIRCNETFGLR LTTYHNLHFLLHLMEQVRQAIREDRLGDFREEFFERYGYNKPNAKSF*" /label="tgt CDS" gene complement(2353305..2354450) /gene="tgt" /locus_tag="BSU_27710" /old_locus_tag="BSU27710" /label="tgt gene" upshifts complement(2353357) /Source="Nicolas_upshifts" /id="U2141" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.432567432567433" /psig="0.164835164835165" /xcortree=2327 /SigmaFactorBS="tacacttaatggagcaggtaagacaggctattcgcgaggatc gtctgggtgatttcaGagaagagttctttgagcgttacggctataacaagccaaatgc g" /listShort="yrbF" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2353401) /Source="Nicolas_upshifts" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2353403..2353422) /Source="Nicolas_upshift_promotors" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2353437..2353442) /Source="Nicolas_upshift_promotors" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2354477..2355505) /gene="queA" /locus_tag="BSU_27720" /old_locus_tag="BSU27720" /EC_number="2.4.99.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15822125, 17083917, 10739928" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15822125, 17083917, 10739928; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine tRNA ribosyltransferase-isomerase" /protein_id="NP_390650.1" /db_xref="EnsemblGenomes-Gn:BSU27720" /db_xref="EnsemblGenomes-Tr:CAB14732" /db_xref="GOA:O32054" /db_xref="InterPro:IPR003699" /db_xref="InterPro:IPR036100" /db_xref="PDB:1YY3" /db_xref="SubtiList:BG12662" /db_xref="UniProtKB/Swiss-Prot:O32054" /translation="MKVDLFDFELPERLIAQVPLEQRDASRLMVLDKHTGELTDSSFK HIISFFNEGDCLVLNNTRVLPARLFGTKEDTGAKVELLLLKQETGDKWETLAKPAKRV KKGTVVTFGDGRLKAICTEELEHGGRKMEFQYDGIFYEVLESLGEMPLPPYIKEQLDD KERYQTVYSKEIGSAAAPTAGLHFTEEILQQLKDKGVQIEFITLHVGLGTFRPVSADE VEEHNMHAEFYQMSEETAAALNKVRENGGRIISVGTTSTRTLETIAGEHDGQFKASSG WTSIFIYPGYEFKAIDGMITNFHLPKSSLIMLVSALAGRENILRAYNHAVEEEYRFFS FGDAMLII*" /label="queA CDS" gene complement(2354477..2355505) /gene="queA" /locus_tag="BSU_27720" /old_locus_tag="BSU27720" /label="queA gene" CDS complement(2355535..2355735) /gene="yrzS" /locus_tag="BSU_27729" /old_locus_tag="BSU27729" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="YP_003097768.1" /db_xref="EnsemblGenomes-Gn:BSU27729" /db_xref="EnsemblGenomes-Tr:CAX52674" /db_xref="GOA:C0H463" /db_xref="InterPro:IPR021320" /db_xref="UniProtKB/Swiss-Prot:C0H463" /translation="MTEFPKIIMILGAVLLIIGAVLHFVGKMPGDIFVKKGNVTFFFP VVTCIIISVVLSILLNLFGRMK*" /label="yrzS CDS" gene complement(2355535..2355735) /gene="yrzS" /locus_tag="BSU_27729" /old_locus_tag="BSU27729" /label="yrzS gene" CDS complement(2355728..2356732) /gene="ruvB" /locus_tag="BSU_27730" /old_locus_tag="BSU27730" /EC_number="3.1.22.4" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14701911, 15317759, 16267290, 19422832, 21600217, 24770420; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction DNA helicase, ATP-dependent component" /protein_id="YP_054590.1" /db_xref="EnsemblGenomes-Gn:BSU27730" /db_xref="EnsemblGenomes-Tr:CAB14733" /db_xref="GOA:O32055" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004605" /db_xref="InterPro:IPR008823" /db_xref="InterPro:IPR008824" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12669" /db_xref="UniProtKB/Swiss-Prot:O32055" /translation="MDERLVSSEADNHESVIEQSLRPQNLAQYIGQHKVKENLRVFID AAKMRQETLDHVLLYGPPGLGKTTLASIVANEMGVELRTTSGPAIERPGDLAAILTAL EPGDVLFIDEIHRLHRSIEEVLYPAMEDFCLDIVIGKGPSARSVRLDLPPFTLVGATT RVGLLTAPLRDRFGVMSRLEYYTQEELADIVTRTADVFEVEIDKPSALEIARRSRGTP RVANRLLRRVRDFAQVLGDSRITEDISQNALERLQVDRLGLDHIDHKLLMGMIEKFNG GPVGLDTISATIGEESHTIEDVYEPYLLQIGFIQRTPRGRIVTPAVYHHFQMEAPRYD *" /label="ruvB CDS" gene complement(2355728..2356732) /gene="ruvB" /locus_tag="BSU_27730" /old_locus_tag="BSU27730" /label="ruvB gene" CDS complement(2356743..2357348) /gene="ruvA" /locus_tag="BSU_27740" /old_locus_tag="BSU27740" /EC_number="3.1.22.4" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14701911, 15317759, 16267290, 24770420" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14701911, 15317759, 16267290, 24770420; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction DNA helicase" /protein_id="NP_390652.1" /db_xref="EnsemblGenomes-Gn:BSU27740" /db_xref="EnsemblGenomes-Tr:CAB14734" /db_xref="GOA:O05392" /db_xref="InterPro:IPR000085" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR011114" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013849" /db_xref="InterPro:IPR036267" /db_xref="SubtiList:BG11973" /db_xref="UniProtKB/Swiss-Prot:O05392" /translation="MIEFVKGTIDYVSPQYIVIENGGIGYQIFTPNPFIYKERSQETI FTYHHIREDAFSLYGFSTREEKALFTKLLNVTGIGPKGALAILGSGDPGAVIQAIENE DEAFLVKFPGVGKKTARQIILDLKGKLADVVPEMIENLFNHEERLEKQTAETALEEAL EALRVLGYAEKEIKKVLPHLKEEIGLTTDQYVKKALQKLLK*" /label="ruvA CDS" gene complement(2356743..2357348) /gene="ruvA" /locus_tag="BSU_27740" /old_locus_tag="BSU27740" /label="ruvA gene" promotor_-10 complement(2357367..2357386) /Source="Nicolas_upshift_promotors" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2357383) /Source="Nicolas_upshifts" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2357385..2357486) /Source="Nicolas_S_feature" /locus_tag="new_2836807_2836908_c" /HighExp="Etha, Heat, S8, S7, S4, S3, S6, S5, Salt, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigB" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1050" promotor_-35 complement(2357397..2357403) /Source="Nicolas_upshift_promotors" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2357487..2357999) /gene="bofC" /locus_tag="BSU_27750" /old_locus_tag="BSU27750" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10931291, 16049010" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10931291, 16049010; Product type f: factor" /codon_start=1 /transl_table=11 /product="bypass of forespore C, intercompartmental signaling factor" /protein_id="NP_390653.1" /db_xref="EnsemblGenomes-Gn:BSU27750" /db_xref="EnsemblGenomes-Tr:CAB14735" /db_xref="GOA:O05391" /db_xref="InterPro:IPR015050" /db_xref="InterPro:IPR015071" /db_xref="PDB:2BW2" /db_xref="SubtiList:BG11917" /db_xref="UniProtKB/Swiss-Prot:O05391" /translation="MKRFSTAYLLLGILCSAAVFLIGAPSRALGAEVEHYEPLQVHVQ LEKVYLDGDVSIEHKHEKVFSMDDFWAAYAGWTLVEQKKGYVLFRKQMDDISPLSKVN GYIGVSDNGVISTFHGRPEPASEPIQSFFQIDLERLESHMQKNLLKGIPFRTKAEFED VIEHMKTYSG*" /label="bofC CDS" gene complement(2357487..2357999) /gene="bofC" /locus_tag="BSU_27750" /old_locus_tag="BSU27750" /label="bofC gene" promotor_-10 complement(2358028..2358039) /Source="Nicolas_upshift_promotors" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="promotor_-10" upshifts complement(2358043) /Source="Nicolas_upshifts" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="upshifts" CDS complement(2358047..2359354) /gene="csbX" /locus_tag="BSU_27760" /old_locus_tag="BSU27760" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9099855, 14638426, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative catecholate siderophose exporter" /protein_id="NP_390654.2" /db_xref="EnsemblGenomes-Gn:BSU27760" /db_xref="EnsemblGenomes-Tr:CAB14736" /db_xref="GOA:O05390" /db_xref="InterPro:IPR004748" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11922" /db_xref="UniProtKB/Swiss-Prot:O05390" /translation="MNTVHAKGNVLNKIGIPSHMVWGYIGVVIFMVGDGLEQGWLSPF LVDHGLSMQQSASLFTMYGIAVTISAWLSGTFVQTWGPRKTMTVGLLAFILGSAAFIG WAIPHMYYPALLGSYALRGLGYPLFAYSFLVWVSYSTSQNILGKAVGWFWFMFTCGLN VLGPFYSSYAVPAFGEINTLWSALLFVAAGGILALFFNKDKFTPIQKQDQPKWKELSK AFTIMFENPKVGIGGVVKTINAIGQFGFAIFLPTYLARYGYSVSEWLQIWGTLFFVNI VFNIIFGAVGDKLGWRNTVMWFGGVGCGIFTLALYYTPQLIGHQYWVLMIIACCYGAA LAGYVPLSALLPTLAPDNKGAAMSVLNLGSGLCAFIAPGIVSLFIGPLGAGGVIWIFA ALYFFSAFLTRFLTISEQSTDVYTEERFVRENVQTNFDKTVKQ*" /label="csbX CDS" gene complement(2358047..2359354) /gene="csbX" /locus_tag="BSU_27760" /old_locus_tag="BSU27760" /label="csbX gene" promotor_-35 complement(2358054..2358060) /Source="Nicolas_upshift_promotors" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="promotor_-35" downshifts complement(2359308) /Source="Nicolas_upshifts" /id="D1420" /incds=0 /nref=2 /ntot=80 /MaxReadThrough="7.18585" /MaxDrop="3.0235" /score="-6.29978124" /energy="-14.3" /TU="U2145,U2146" /idTUdmin="U2146" /TUdmin="-1793" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2359378..2359396) /Source="Nicolas_upshift_promotors" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="promotor_-10" upshifts complement(2359393) /Source="Nicolas_upshifts" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="upshifts" promotor_-35 complement(2359411..2359417) /Source="Nicolas_upshift_promotors" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="promotor_-35" CDS complement(2359425..2360450) /gene="yrbE" /locus_tag="BSU_27770" /old_locus_tag="BSU27770" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28043209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative inositol-related oxidoreductase" /protein_id="NP_390655.1" /db_xref="EnsemblGenomes-Gn:BSU27770" /db_xref="EnsemblGenomes-Tr:CAB14737" /db_xref="GOA:O05389" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR030827" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12280" /db_xref="UniProtKB/Swiss-Prot:O05389" /translation="MTKQIVTGIIGAGRIGKLHVQNISRIPHMKIKAISDIQASRIKS WADSHQIEYITSDYRDLLHDPDIDAIFICSPTAVHAQMIKEAAEAKKHIFCEKPVSFS LDETSEALAAVRKHGVTLQVGFNRRFDPHFKKIKTIVENGEIGTPHLLKITSRDPEPP NIDYVRTSGGLFMDMSIHDFDMARYIMGSEVTEVYAKGAALVNPSFAELGDIDTAVIT LTFENGAMAVIDNSRQAVYGYDQRVEVFGTKGSAAADNSRPTTVEVSTADFVMKDKPH FFFLERYKDSYEEEILRFAEAIGTNQETPCTGNDGLQAGRIARAAQQSLAFGMPVSIE HTEKIAF*" /label="yrbE CDS" gene complement(2359425..2360450) /gene="yrbE" /locus_tag="BSU_27770" /old_locus_tag="BSU27770" /label="yrbE gene" promotor_-10 complement(2360487..2360506) /Source="Nicolas_upshift_promotors" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="promotor_-10" upshifts complement(2360507) /Source="Nicolas_upshifts" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="upshifts" promotor_-35 complement(2360521..2360528) /Source="Nicolas_upshift_promotors" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="promotor_-35" promotor_-35 2360576..2360583 /Source="Nicolas_upshift_promotors" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2360597..2360616 /Source="Nicolas_upshift_promotors" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2360605 /Source="Nicolas_upshifts" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2360637..2360642 /Source="Nicolas_upshift_promotors" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2360651 /Source="Nicolas_upshifts" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2360658..2360676 /Source="Nicolas_upshift_promotors" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2360688..2361335 /gene="yrzF" /locus_tag="BSU_27785" /old_locus_tag="BSU27785" /EC_number="2.7.11.1" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative serine/threonine-protein kinase" /protein_id="NP_390656.2" /db_xref="EnsemblGenomes-Gn:BSU27785" /db_xref="EnsemblGenomes-Tr:CAB14738" /db_xref="GOA:O32057" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG13816" /db_xref="UniProtKB/Swiss-Prot:O32057" /translation="MLTKAEALAHTVIYRKNSRFDKVKEKSEELTLIGKGRSAYVFAL TEGGRKMALKVFFPEYQATAVKEAAIYEKLAGSAFYPDIYETGDSFILMEYIKGETFY NCLKKGIAISDDMIQQVEEALSDARAAGLNPSDIHLRNLILTETGAVRVIDVARFEQT KTCTQWDDLKSAYHALYKKPIFPKKIPGFWLEIIAFLYKKDWFQKHFAQRKRKYS*" /label="yrzF CDS" gene 2360688..2361335 /gene="yrzF" /locus_tag="BSU_27785" /old_locus_tag="BSU27785" /label="yrzF gene" S_feature complement(2361010..2361343) /Source="Nicolas_S_feature" /locus_tag="new_2840432_2840765_c" /HighExp="LPhT, S8, BI, S7, S6, C30, Sw, BC, Gly, C90" /AntisenseName="yrzF" /AntisenseCor="0.348831504804749" /AntisenseRegPval="-8.4" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1051" downshifts 2361314 /Source="Nicolas_upshifts" /id="D1421" /incds=0 /nref=29 /ntot=228 /MaxReadThrough="2.4121" /MaxDrop="5.05737" /score="20.8102477" /energy="-18.2" /TU="NA" /idTUdmin="U2147" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" S_feature complement(2361345..2361542) /Source="Nicolas_S_feature" /locus_tag="new_2840767_2840964_c" /HighExp="LPhT, BI, B60, S8, Gly, S7, S6, B36, S5, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99984200000000001" /TUshortSig="Sig-" /TUshortPSig="0.032" /TUlongSig="NA" /TUlongPSig="NA" /label="S1052" CDS complement(2361381..2361503) /locus_tag="BSU_27786" /old_locus_tag="BSU27786" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513992.1" /db_xref="EnsemblGenomes-Gn:BSU27786" /db_xref="EnsemblGenomes-Tr:CCQ48603" /db_xref="UniProtKB/TrEMBL:L8EAY3" /translation="MEKTYCHSGEKDPEAVYLTVRGYRIKLSPEQMKLISAVRK*" /label="hypothetical protein CDS" gene complement(2361381..2361503) /locus_tag="BSU_27786" /old_locus_tag="BSU27786" /label="gene" downshifts complement(2361388) /Source="Nicolas_upshifts" /id="D1422" /incds=0 /nref=3 /ntot=19 /MaxReadThrough="4.39913" /MaxDrop="4.52186" /score="39.5790138" /energy="-18.2" /TU="NA" /idTUdmin="U2149" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(2361551) /Source="Nicolas_upshifts" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2361552..2361569) /Source="Nicolas_upshift_promotors" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2361576..2361583) /Source="Nicolas_upshift_promotors" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2361588..2361878 /gene="yrzH" /locus_tag="BSU_27800" /old_locus_tag="BSU27800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390658.2" /db_xref="EnsemblGenomes-Gn:BSU27800" /db_xref="EnsemblGenomes-Tr:CAB14740" /db_xref="SubtiList:BG13818" /db_xref="UniProtKB/Swiss-Prot:O32059" /translation="MNPIYSKMREKKGESHIKTENTLSLDAARGELVNEKTLVKRTIY WNYPDSRPAVTWINHNTVKIGNQTLHLDTDETYDWRKDDHWIREEPPQASVR*" /label="yrzH CDS" gene 2361588..2361878 /gene="yrzH" /locus_tag="BSU_27800" /old_locus_tag="BSU27800" /label="yrzH gene" misc_feature 2361599..2361618 /Source="Nicolas_upshift_promotors" /id="U2150" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.462537462537463" /psig="0.903096903096903" /xcortree=657 /SigmaFactorBS="atcttatcattgctttattgaggtaattttaaagaaatgtaa agattatatgaatccgatATATAGTAAAATGAGAGAAAaaaagggagagagtcacatt a" /listShort="S1053, yrzH, yrzT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 2361599..2361746 /Source="Nicolas_S_feature" /locus_tag="new_2841021_2841168" /HighExp="T3.30H, T4.0H, T3.0H, T2.0H, T2.30H, T5.0H, M9-stat, S7, T1.30H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99999400000000005" /TUshortSig="SigA" /TUshortPSig="0.903" /TUlongSig="NA" /TUlongPSig="NA" /label="S1053" upshifts 2361599 /Source="Nicolas_upshifts" /id="U2150" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.462537462537463" /psig="0.903096903096903" /xcortree=657 /SigmaFactorBS="atcttatcattgctttattgaggtaattttaaagaaatgtaa agattatatgaatccgatATATAGTAAAATGAGAGAAAaaaagggagagagtcacatt a" /listShort="S1053, yrzH, yrzT" /GFF_Attribute="listLong" /label="upshifts" CDS 2361885..2362025 /gene="yrzT" /locus_tag="BSU_27809" /old_locus_tag="BSU27809" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097769.1" /db_xref="EnsemblGenomes-Gn:BSU27809" /db_xref="EnsemblGenomes-Tr:CAX52675" /db_xref="GOA:C0H464" /db_xref="UniProtKB/Swiss-Prot:C0H464" /translation="MNKMNGTNDEKHFNHFVIALSFIYGLTELGYLLLKDFITIAISL PL*" /label="yrzT CDS" gene 2361885..2362025 /gene="yrzT" /locus_tag="BSU_27809" /old_locus_tag="BSU27809" /label="yrzT gene" downshifts 2362014 /Source="Nicolas_upshifts" /id="D1423" /incds=0 /nref=139 /ntot=241 /MaxReadThrough="0.64189" /MaxDrop="4.74983" /score="23.2933855" /energy="-9.9" /TU="NA" /idTUdmin="U2150" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 2362074..2362080 /Source="Nicolas_upshift_promotors" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2362088..2362188 /Source="Nicolas_upshift_promotors" /id="U2152" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.383616383616384" /psig="0.376623376623377" /xcortree=317 /SigmaFactorBS="ttacaggtcatataatgtgacaaatcgattgtagaaatagtt cgattagaccaaaatcctttttatacatgtattcgaatttgaagtgagggggaagctt g" /listShort="yrbD" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 2362095..2362113 /Source="Nicolas_upshift_promotors" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2362096 /Source="Nicolas_upshifts" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="upshifts" upshifts 2362148 /Source="Nicolas_upshifts" /id="U2152" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.383616383616384" /psig="0.376623376623377" /xcortree=317 /SigmaFactorBS="ttacaggtcatataatgtgacaaatcgattgtagaaatagtt cgattagaccaaaatcctttttatacatgtattcgaatttgaagtgagggggaagctt g" /listShort="yrbD" /GFF_Attribute="listLong" /label="upshifts" CDS 2362189..2363643 /gene="alaP" /locus_tag="BSU_27810" /old_locus_tag="BSU27810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1400476, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium/proton-dependent alanine transporter" /protein_id="NP_390659.2" /db_xref="EnsemblGenomes-Gn:BSU27810" /db_xref="EnsemblGenomes-Tr:CAB14741" /db_xref="GOA:O32060" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG13784" /db_xref="UniProtKB/Swiss-Prot:O32060" /translation="MADFVASLNAVLWSTPVIYILLGIGFAFSIMTRFLQVRHLKEMI VQMFKGKSSEAGVSSFQALSIALSGRVGTGNIAGVATAIAFGGPGAVFWMWAIAFIGA ASAFVESTLAQIYKVKQDGQYRGGPAYYIEKGLGIKWFAVLFAAAALIAMAFLMPGVQ SNSIAAGIQNAFGISPFVTGCGLVLLLGFIIFGGVKRIANAAQMIVPFMAIGYILLSL IIIVMNVSELPAVISLIFKSAFALDSAFGGLIGMAISWGVKRGIYSNEAGQGTGPHPA AAAEVSHPVKQGLVQAFSVYIDTLFVCSATAFMILFTGMYNTQAADGSFIVHQLKGVE AGPGFTQAAIDSVLPGFGAGFVAIALFFFAFTTIMAYYYIAETNIAYLARGRESKWAM LGLKLIILAATFYGTVKTASLAWALGDAGLGIMVWLNVIAIVLLAKPALLALKDYERQ KKQGLDPIFDPKALGIKNADFWEKEYTHESERVS*" /label="alaP CDS" gene 2362189..2363643 /gene="alaP" /locus_tag="BSU_27810" /old_locus_tag="BSU27810" /label="alaP gene" downshifts 2363644 /Source="Nicolas_upshifts" /id="D1424" /incds=0 /nref=6 /ntot=43 /MaxReadThrough="5.01314" /MaxDrop="4.4617" /score="6.86850608" /energy="-10.8" /TU="U2151" /idTUdmin="U2152" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2363684..2364406) /gene="yrbC" /locus_tag="BSU_27820" /old_locus_tag="BSU27820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12060744, 18641136, 20647113; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor regulating gene expression" /protein_id="NP_390660.1" /db_xref="EnsemblGenomes-Gn:BSU27820" /db_xref="EnsemblGenomes-Tr:CAB14742" /db_xref="GOA:P94447" /db_xref="InterPro:IPR002876" /db_xref="InterPro:IPR017856" /db_xref="InterPro:IPR026564" /db_xref="InterPro:IPR029072" /db_xref="SubtiList:BG13783" /db_xref="UniProtKB/Swiss-Prot:P94447" /translation="MAGHSKWKNIQKRKNAQDAKRGKIFMKLAKEIYVAAKEGGADPE ANSALRLVIEKAKGANMPNENIDRAIKKAAGGQDGSSYEEITYEGYGPSGIAVMVECV TDNKNRTASNVRTAFNKNGGSLGESGCVAFLFERKGFITIDRTERQIEEDELMLDVLE AGGEELRIEEDLYEVFTEPEHFEEVKTALESKYLISSAEVTMLPNTYAEADDQAVEKL ETLIDVLEDDDDVQEVYTNYRS*" /label="yrbC CDS" gene complement(2363684..2364406) /gene="yrbC" /locus_tag="BSU_27820" /old_locus_tag="BSU27820" /label="yrbC gene" S_feature 2363689..2364110 /Source="Nicolas_S_feature" /locus_tag="new_2843111_2843532" /HighExp="S8, S6, S7, BT, C30, S5, S4, LoTm, C90, S3" /AntisenseName="yrbC" /AntisenseCor="-8.4330852334841305E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1054" downshifts complement(2363700) /Source="Nicolas_upshifts" /id="D1425" /incds=0 /nref=11 /ntot=164 /MaxReadThrough="3.2014" /MaxDrop="3.66865" /score="23.9031001" /energy="-16" /TU="U2153" /idTUdmin="U2153" /TUdmin="-574" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2364429..2364448) /Source="Nicolas_upshift_promotors" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2364446) /Source="Nicolas_upshifts" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2364462..2364469) /Source="Nicolas_upshift_promotors" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2364509..2365105) /gene="sgpA" /locus_tag="BSU_27830" /old_locus_tag="BSU27830" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9770294, 10438771, 12562816, 17322312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9770294, 10438771, 12562816, 17322312; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_390661.2" /db_xref="EnsemblGenomes-Gn:BSU27830" /db_xref="EnsemblGenomes-Tr:CAB14743" /db_xref="GOA:P94446" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG13782" /db_xref="UniProtKB/Swiss-Prot:P94446" /translation="MGKKMTIASLILMTAGLTACGANDNAMNDTRNNGNTRPIGYYTN ENDADRQGDGIDHDGPVSELMEDQNDGNRNTTNVNNRDRVTADDRVPLATDGTYNNTN NRNMNRNAANNGYDNQENRRLAAKIANRVKQVKNVNDTQVMVSDDRVVIAVKSHREFT KSDRDNVVKAARNYANGRDVQVSTDKGLFRKLHKMNNR*" /label="sgpA CDS" gene complement(2364509..2365105) /gene="sgpA" /locus_tag="BSU_27830" /old_locus_tag="BSU27830" /label="sgpA gene" downshifts complement(2364524) /Source="Nicolas_upshifts" /id="D1426" /incds=0 /nref=96 /ntot=172 /MaxReadThrough="2.47709" /MaxDrop="7.18444" /score="23.9031001" /energy="-16" /TU="NA" /idTUdmin="U2154" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2365148..2365159) /Source="Nicolas_upshift_promotors" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2365150) /Source="Nicolas_upshifts" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2365152..2365216) /Source="Nicolas_S_feature" /locus_tag="new_2844574_2844638_c" /HighExp="B36, LoTm, S8, S6, S5, BT, B60, S4, S7, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1055" promotor_-35 complement(2365174..2365180) /Source="Nicolas_upshift_promotors" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2365253..2366416) /gene="safA" /locus_tag="BSU_27840" /old_locus_tag="BSU27840" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10438771, 10714986, 10714992, 11040425, 15901704, 26953338" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438771, 10714986, 10714992, 11040425, 15901704, 26953338; Product type f : factor" /codon_start=1 /transl_table=11 /product="morphogenetic protein associated with SpoVID" /protein_id="NP_390662.1" /db_xref="EnsemblGenomes-Gn:BSU27840" /db_xref="EnsemblGenomes-Tr:CAB14744" /db_xref="GOA:O32062" /db_xref="InterPro:IPR014248" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13781" /db_xref="UniProtKB/Swiss-Prot:O32062" /translation="MKIHIVQKGDSLWKIAEKYGVDVEEVKKLNTQLSNPDLIMPGMK IKVPSEGVPVRKEPKAGKSPAAGSVKQEHPYAKEKPKSVVDVEDTKPKEKKSMPYVPP MPNLQENVYPEADVNDYYDMKQLFQPWSPPKPEEPKKHHDGNMDHMYHMQDQFPQQEA MSNMENANYPNMPNMPKAPEVGGIEEENVHHTVPNMPMPAVQPYYHYPAHFVPCPVPV SPILPGSGLCYPYYPAQAYPMHPMHGYQPGFVSPQYDPGYENQHHENSHHGHYGSYGA PQYASPAYGSPYGHMPYGPYYGTPQVMGAYQPAAAHGYMPYKDHDDCGCDGDHQPYFS APGHSGMGAYGSPNMPYGTANPNPNPYSAGVSMPMTNQPSVNQMFGRPEEENE*" /label="safA CDS" gene complement(2365253..2366416) /gene="safA" /locus_tag="BSU_27840" /old_locus_tag="BSU27840" /label="safA gene" downshifts complement(2365261) /Source="Nicolas_upshifts" /id="D1427" /incds=0 /nref=34 /ntot=189 /MaxReadThrough="5.61903" /MaxDrop="3.9565" /score="38.1347732" /energy="-11.1" /TU="U2155,U2156,U2159" /idTUdmin="U2154" /TUdmin="-749" /isTUend="FALSE" /label="downshifts" S_feature complement(2366417..2366492) /Source="Nicolas_S_feature" /locus_tag="new_2845839_2845914_c" /HighExp="S5, S4, B36, LoTm, S3, B60, S7, S6, Pyr, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1056" promotor_-10 complement(2366468..2366486) /Source="Nicolas_upshift_promotors" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2366492) /Source="Nicolas_upshifts" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2366502..2366507) /Source="Nicolas_upshift_promotors" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2366533..2367639) /gene="nadA" /locus_tag="BSU_27850" /old_locus_tag="BSU27850" /EC_number="2.5.1.72" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:15898769, 15937336, 15967443, 18959769, 26455817" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15898769, 15937336, 15967443, 18959769, 26455817; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="quinolinate synthetase" /protein_id="NP_390663.1" /db_xref="EnsemblGenomes-Gn:BSU27850" /db_xref="EnsemblGenomes-Tr:CAB14745" /db_xref="GOA:Q9KWZ1" /db_xref="InterPro:IPR003473" /db_xref="InterPro:IPR023515" /db_xref="InterPro:IPR036094" /db_xref="SubtiList:BG12629" /db_xref="UniProtKB/Swiss-Prot:Q9KWZ1" /translation="MSILDVIKQSNDMMPESYKELSRKDMETRVAAIKKKFGSRLFIP GHHYQKDEVIQFADQTGDSLQLAQVAEKNKEADYIVFCGVHFMAETADMLTSEQQTVV LPDMRAGCSMADMADMQQTNRAWKKLQHIFGDTIIPLTYVNSTAEIKAFVGKHGGATV TSSNAKKVLEWAFTQKKRILFLPDQHLGRNTAYDLGIALEDMAVWDPMKDELVAESGH TNVKVILWKGHCSVHEKFTTKNIHDMRERDPDIQIIVHPECSHEVVTLSDDNGSTKYI IDTINQAPAGSKWAIGTEMNLVQRIIHEHPDKQIESLNPDMCPCLTMNRIDLPHLLWS LEQIEKGEPSGVIKVPKAIQEDALLALNRMLSIT*" /label="nadA CDS" gene complement(2366533..2367639) /gene="nadA" /locus_tag="BSU_27850" /old_locus_tag="BSU27850" /label="nadA gene" promotor_-10 complement(2367215..2367233) /Source="Nicolas_upshift_promotors" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2367240) /Source="Nicolas_upshifts" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2367249..2367254) /Source="Nicolas_upshift_promotors" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2367551 /Source="Nicolas_upshifts" /id="U2157" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=25 /SigmaFactorBS="ttttgataatgatggcctggtataaagagcctgctgccgaac tttttcttaatggcggcaaCGCGcgtttccatatcctttctcgatagttctttataac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2367552..2367555 /Source="Nicolas_upshift_promotors" /id="U2157" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=25 /SigmaFactorBS="ttttgataatgatggcctggtataaagagcctgctgccgaac tttttcttaatggcggcaaCGCGcgtttccatatcctttctcgatagttctttataac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2367626..2368495) /gene="nadC" /locus_tag="BSU_27860" /old_locus_tag="BSU27860" /EC_number="2.4.2.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8419294, 28618168; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate-nucleotide pyrophosphorylase (quinolinate phosphoribosyltransferase)" /protein_id="NP_390664.1" /db_xref="EnsemblGenomes-Gn:BSU27860" /db_xref="EnsemblGenomes-Tr:CAB14746" /db_xref="GOA:P39666" /db_xref="InterPro:IPR002638" /db_xref="InterPro:IPR004393" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022412" /db_xref="InterPro:IPR027277" /db_xref="InterPro:IPR036068" /db_xref="InterPro:IPR037128" /db_xref="SubtiList:BG10868" /db_xref="UniProtKB/Swiss-Prot:P39666" /translation="MNHLQLKKLLNHFFLEDIGTGDLTSQSIFGEQSCEAEIVAKSEG IFAGAAIIKEGFSLLDENVQSILHKKDGDMLHKGEVIAELHGPAAALLSGERVVLNLI QRLSGIATMTREAVRCLDDEQIKICDTRKTTPGLRMLEKYAVRAGGGYNHRFGLYDGI MIKDNHIAACGSILEACKKARQAAGHMVNIEVEIETEEQLREAIAAGADVIMFDNCPP DTVRHFAKLTPANIKTEASGGITLESLPAFKGTGVNYISLGFLTHSVKSLDISMDVTL SNESVEECCYVNS*" /label="nadC CDS" gene complement(2367626..2368495) /gene="nadC" /locus_tag="BSU_27860" /old_locus_tag="BSU27860" /label="nadC gene" downshifts 2367720 /Source="Nicolas_upshifts" /id="D1428" /incds=1 /nref=4 /ntot=107 /MaxReadThrough="0.495279999999999" /MaxDrop="3.83418" /score="-8.75482157" /energy="-7.4" /TU="NA" /idTUdmin="U2157" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(2368449..2370044) /gene="nadB" /locus_tag="BSU_27870" /old_locus_tag="BSU27870" /EC_number="1.4.3.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8444804, 16199587, 18959769" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8444804, 16199587, 18959769; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-aspartate oxidase" /protein_id="NP_390665.1" /db_xref="EnsemblGenomes-Gn:BSU27870" /db_xref="EnsemblGenomes-Tr:CAB14747" /db_xref="GOA:P38032" /db_xref="InterPro:IPR003953" /db_xref="InterPro:IPR005288" /db_xref="InterPro:IPR015939" /db_xref="InterPro:IPR027477" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR037099" /db_xref="SubtiList:BG10867" /db_xref="UniProtKB/Swiss-Prot:P38032" /translation="MSKKTIAVIGSGAAALSLAAAFPPSYEVTVITKKSVKNSNSVYA QGGIAAAYAKDDSIEAHLEDTLYAGCGHNNLAIVADVLHDGKMMVQSLLERGFPFDRN ERGGVCLGREGAHSYNRIFHAGGDATGRLLIDYLLKRINSKIKLIENETAADLLIEDG RCIGVMTKDSKGRLKVRHADEVVLAAGGCGNLFLHHTNDLTVTGDGLSLAYRAGAELT DLEFTQFHPTLLVKNGVSYGLVSEAVRGEGGCLVDENGRRIMAERHPLGDLAPRDIVS RVIHEEMAKGNRVYIDFSAISDFETRFPTITAICEKAGIDIHSGKIPVAPGMHFLMGG VSVNRWGETTVPGLYAIGETACSGLHGANRLASNSLLEALVFGKRAAEHIIQKPVYNR QYQSGLETSVFYEVPDIEGHELQSKMTSHMSILREQSSLIELSIWLHTLPFQEVNVKD ITIRQMELSHLWQTAKLMTFSALLREESRGAHFRTDFPHAEVSWQGRQIVHTKKGTKI RKNEGIWNNESFTAEKITESLFS*" /label="nadB CDS" gene complement(2368449..2370044) /gene="nadB" /locus_tag="BSU_27870" /old_locus_tag="BSU27870" /label="nadB gene" promotor_-35 2370072..2370079 /Source="Nicolas_upshift_promotors" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2370072..2370091) /Source="Nicolas_upshift_promotors" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2370093 /Source="Nicolas_upshifts" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2370095..2370114 /Source="Nicolas_upshift_promotors" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2370096) /Source="Nicolas_upshifts" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2370106..2370113) /Source="Nicolas_upshift_promotors" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2370147..2371334 /gene="nifS" /locus_tag="BSU_27880" /old_locus_tag="BSU27880" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8444804, 14567704, 16199587, 25447671, 26443755, 28882201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8444804, 14567704, 16199587, 25447671, 26443755, 28882201; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="desulfurase involved in iron-sulfur clusters forNAD biosynthesis" /protein_id="NP_390666.1" /db_xref="EnsemblGenomes-Gn:BSU27880" /db_xref="EnsemblGenomes-Tr:CAB14748" /db_xref="GOA:P38033" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG10866" /db_xref="UniProtKB/Swiss-Prot:P38033" /translation="MIYLDYAATTPICEEALTVYQKLSMDMYGNASSLHDAGGKAKHI LEYCREKIANIIGGEASGIYFTSGGTESNFLAIQSLLNGLPKTKRHFITTAMEHQSIH NCAAFLEQQGYDVTVIEPNEYGLITEEILLTHIRPETGLVSIQHANSETGIIQPIQHL SSYLHNKGILLHCDAVQTFGKIPINTKNLGVDALSMSSHKIHGPKGVGAVYIRPDVPW KPVYPLTTHEYGFRAGTVNVPGIGAFTAAAELIVSEMEKQISRNEALRTYFLDQIRIR SLPVTLAADTSKAECLPHIIGCFFHSFEGQYVMLECNRSNICISTGSACSAGYHGPSE TMKALRKTEQEALQFIRISFGRHTTAEQLEQLLHTFTVLWEQKKGEFDIDRRIKANGR QQA*" /label="nifS CDS" gene 2370147..2371334 /gene="nifS" /locus_tag="BSU_27880" /old_locus_tag="BSU27880" /label="nifS gene" promotor_-10 complement(2370148..2370167) /Source="Nicolas_upshift_promotors" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2370166) /Source="Nicolas_upshifts" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2370182..2370191) /Source="Nicolas_upshift_promotors" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2371049..2371054 /Source="Nicolas_upshift_promotors" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2371063 /Source="Nicolas_upshifts" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2371065..2371084 /Source="Nicolas_upshift_promotors" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2371294..2371836 /gene="niaR" /locus_tag="BSU_27890" /old_locus_tag="BSU27890" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16199587, 18276644" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16199587, 18276644; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of de novo NAD biosynthesis" /protein_id="NP_390667.2" /db_xref="EnsemblGenomes-Gn:BSU27890" /db_xref="EnsemblGenomes-Tr:CAB14749" /db_xref="GOA:P39667" /db_xref="InterPro:IPR004173" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR026043" /db_xref="InterPro:IPR035922" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10865" /db_xref="UniProtKB/Swiss-Prot:P39667" /translation="MTEELKLMGANRRDQLLLWLKESKSPLTGGELAKKANVSRQVIV QDISLLKAKNVPIIATSQGYVYMDAAAQQHQQAERIIACLHGPERTEEELQLIVDEGV TVKDVKIEHPVYGDLTAAIQVGTRKEVSHFIKKINSTNAAYLSQLTDGVHLHTLTAPD EHRIDQACQALEEAGILIKD*" /label="niaR CDS" gene 2371294..2371836 /gene="niaR" /locus_tag="BSU_27890" /old_locus_tag="BSU27890" /label="niaR gene" downshifts 2371819 /Source="Nicolas_upshifts" /id="D1429" /incds=0 /nref=109 /ntot=246 /MaxReadThrough="3.55509" /MaxDrop="5.04771" /score="15.054047" /energy="-5.6" /TU="U2158" /idTUdmin="U2161" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(2371861..2372718) /gene="pheA" /locus_tag="BSU_27900" /old_locus_tag="BSU27900" /EC_number="4.2.1.51" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:104661, 114523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 104661, 114523; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prephenate dehydratase" /protein_id="NP_390668.1" /db_xref="EnsemblGenomes-Gn:BSU27900" /db_xref="EnsemblGenomes-Tr:CAB14750" /db_xref="GOA:P21203" /db_xref="InterPro:IPR001086" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR008242" /db_xref="InterPro:IPR018528" /db_xref="SubtiList:BG10914" /db_xref="UniProtKB/Swiss-Prot:P21203" /translation="MKVGYLGPAATFTHLAVSSCFQNGAEHVAYRTIPECIDAAVAGE VDFAFVPLENALEGSVNLTIDYLIHEQPLPIVGEMTLPIHQHLLVHPSRENAWKELDK IYSHSHAIAQCHKFLHRHFPSVPYEYANSTGAAAKFVSDHPELNIGVIANDMAASTYE LKIVKRDIQDYRDNHTRFVILSPDENISFEVNSKLSSRPKTTLMVMLPQDDQSGALHR VLSAFSWRNLNLSKIESRPTKTGLGHYFFIIDIEKAFDDVLIPGAMQELEALGCKVRL LGAYQSYQL*" /label="pheA CDS" gene complement(2371861..2372718) /gene="pheA" /locus_tag="BSU_27900" /old_locus_tag="BSU27900" /label="pheA gene" S_feature 2371864..2372573 /Source="Nicolas_S_feature" /locus_tag="new_2851286_2851995" /HighExp="S2, T-5.40H, T3.30H, T-4.40H, GM-0.2, GM-0.1, Pyr, T4.0H, T5.0H, GM 10" /AntisenseName="pheA" /AntisenseCor="-0.15664933741609299" /AntisenseRegPval="-2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1057" downshifts complement(2371881) /Source="Nicolas_upshifts" /id="D1430" /incds=0 /nref=173 /ntot=247 /MaxReadThrough="1.87872" /MaxDrop="5.15605" /score="13.965695" /energy="-5.6" /TU="NA" /idTUdmin="U2162" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2372735..2373178) /gene="thrR" /locus_tag="BSU_27910" /old_locus_tag="BSU27910" /experiment="publication(s) with functional evidences, PMID:2537815, 27260660" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2537815, 27260660; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of operons hom-thrCB and thrD" /protein_id="NP_390669.1" /db_xref="EnsemblGenomes-Gn:BSU27910" /db_xref="EnsemblGenomes-Tr:CAB14751" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR008310" /db_xref="SubtiList:BG10913" /db_xref="UniProtKB/Swiss-Prot:P21204" /translation="MKEETFYLVREDVLPDAMRKTLEVKKLLDRKKADSVADAVQKVD LSRSAFYKYRDAVFPFYTMVKEQIITLFFHLEDRSGALSQLLQAVADSGSNVLSIHQT IPLQGRANVTLSISTSAMEEDIHTLMNKLRKFDFVEKVEILGSGA*" /label="thrR CDS" gene complement(2372735..2373178) /gene="thrR" /locus_tag="BSU_27910" /old_locus_tag="BSU27910" /label="thrR gene" CDS complement(2373239..2374525) /gene="obgE" /locus_tag="BSU_27920" /old_locus_tag="BSU27920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10781545, 12682299, 15325267, 15827604, 18689482, 20830302, 24844575, 26951678, 28357361" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10781545, 12682299, 15325267, 15827604, 18689482, 20830302, 24844575, 26951678, 28357361; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ppGpp-binding GTPase involved in cell portioning, DNA repair and ribosome assembly" /protein_id="NP_390670.1" /db_xref="EnsemblGenomes-Gn:BSU27920" /db_xref="EnsemblGenomes-Tr:CAB14752" /db_xref="GOA:P20964" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR006074" /db_xref="InterPro:IPR006169" /db_xref="InterPro:IPR014100" /db_xref="InterPro:IPR015349" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031167" /db_xref="InterPro:IPR035101" /db_xref="InterPro:IPR036346" /db_xref="InterPro:IPR036726" /db_xref="PDB:1LNZ" /db_xref="SubtiList:BG10337" /db_xref="UniProtKB/Swiss-Prot:P20964" /translation="MFVDQVKVYVKGGDGGNGMVAFRREKYVPKGGPAGGDGGKGGDV VFEVDEGLRTLMDFRYKKHFKAIRGEHGMSKNQHGRNADDMVIKVPPGTVVTDDDTKQ VIADLTEHGQRAVIARGGRGGRGNSRFATPANPAPQLSENGEPGKERYIVLELKVLAD VGLVGFPSVGKSTLLSVVSSAKPKIADYHFTTLVPNLGMVETDDGRSFVMADLPGLIE GAHQGVGLGHQFLRHIERTRVIVHVIDMSGLEGRDPYDDYLTINQELSEYNLRLTERP QIIVANKMDMPEAAENLEAFKEKLTDDYPVFPISAVTREGLRELLFEVANQLENTPEF PLYDEEELTQNRVMYTMENEEVPFNITRDPDGVFVLSGDSLERLFKMTDFSRDESVKR FARQMRGMGVDEALRERGAKDGDIIRLLEFEFEFID*" /label="obgE CDS" gene complement(2373239..2374525) /gene="obgE" /locus_tag="BSU_27920" /old_locus_tag="BSU27920" /label="obgE gene" CDS complement(2374559..2375137) /gene="spo0B" /locus_tag="BSU_27930" /old_locus_tag="BSU27930" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9443976, 9477965, 9726997, 9809070, 10997904, 16788205, 27679485" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9443976, 9477965, 9726997, 9809070, 10997904, 16788205, 27679485; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation initiation phosphotransferase" /protein_id="NP_390671.1" /db_xref="EnsemblGenomes-Gn:BSU27930" /db_xref="EnsemblGenomes-Tr:CAB14753" /db_xref="GOA:P06535" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR016122" /db_xref="InterPro:IPR037100" /db_xref="PDB:1F51" /db_xref="PDB:1IXM" /db_xref="PDB:2FTK" /db_xref="SubtiList:BG10336" /db_xref="UniProtKB/Swiss-Prot:P06535" /translation="MKDVSKNQEENISDTALTNELIHLLGHSRHDWMNKLQLIKGNLS LQKYDRVFEMIEEMVIDAKHESKLSNLKTPHLAFDFLTFNWKTHYMTLEYEVLGEIKD LSAYDQKLAKLMRKLFHLFDQAVSRESENHLTVSLQTDHPDRQLILYLDFHGAFADPS AFDDIRQNGYEDVDIMRFEITSHECLIEIGLD*" /label="spo0B CDS" gene complement(2374559..2375137) /gene="spo0B" /locus_tag="BSU_27930" /old_locus_tag="BSU27930" /label="spo0B gene" S_feature complement(2375138..2375203) /Source="Nicolas_S_feature" /locus_tag="new_2854560_2854625_c" /HighExp="Cold, H2O2, G135, Paraq, G180, Oxctl, G150, C30, LPh, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigEF" /TUlongPSig=1 /label="S1058" promotor_-10 complement(2375188..2375207) /Source="Nicolas_upshift_promotors" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2375203) /Source="Nicolas_upshifts" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2375205..2375422) /Source="Nicolas_S_feature" /locus_tag="new_2854627_2854844_c" /HighExp="Cold, G135, H2O2, Paraq, G180, Oxctl, G150, C30, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S1059" CDS 2375215..2375337 /locus_tag="BSU_27935" /old_locus_tag="BSU27935" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513993.1" /translation="MLEKQLFFPEISCSFFLALVDLQPGRTFYVLLLGEHIQWV*" /label="hypothetical protein CDS" gene 2375215..2375337 /locus_tag="BSU_27935" /old_locus_tag="BSU27935" /label="gene" promotor_-35 complement(2375221..2375228) /Source="Nicolas_upshift_promotors" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2375458..2375742) /gene="rpmA" /locus_tag="BSU_27940" /old_locus_tag="BSU27940" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9000630, 9588797, 11399077, 12682299, 14586115, 17981968, 22720735, 24335279, 25388641, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9000630, 9588797, 11399077, 12682299, 14586115, 17981968, 22720735, 24335279, 25388641, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L27 (BL24)" /protein_id="NP_390672.1" /db_xref="EnsemblGenomes-Gn:BSU27940" /db_xref="EnsemblGenomes-Tr:CAB14754" /db_xref="GOA:P05657" /db_xref="InterPro:IPR001684" /db_xref="InterPro:IPR018261" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10335" /db_xref="UniProtKB/Swiss-Prot:P05657" /translation="MLRLDLQFFASKKGVGSTKNGRDSEAKRLGAKRADGQFVTGGSI LYRQRGTKIYPGENVGRGGDDTLFAKIDGTVKFERFGRDRKKVSVYPVAQ*" /label="rpmA CDS" gene complement(2375458..2375742) /gene="rpmA" /locus_tag="BSU_27940" /old_locus_tag="BSU27940" /label="rpmA gene" downshifts complement(2375467) /Source="Nicolas_upshifts" /id="D1431" /incds=0 /nref=212 /ntot=261 /MaxReadThrough="7.39131" /MaxDrop="7.26483" /score="32.4992871" /energy="-12.5" /TU="U2163" /idTUdmin="U2164" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" CDS complement(2375755..2376093) /gene="rppA" /locus_tag="BSU_27950" /old_locus_tag="BSU27950" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11567142, 22333191, 25388641, 27435445, 28187498; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein L27 specific N-terminal end cysteine protease" /protein_id="NP_390673.2" /db_xref="EnsemblGenomes-Gn:BSU27950" /db_xref="EnsemblGenomes-Tr:CAB14755" /db_xref="InterPro:IPR007422" /db_xref="InterPro:IPR036764" /db_xref="SubtiList:BG10334" /db_xref="UniProtKB/Swiss-Prot:P26942" /translation="MIQATIRRSHDKGILSFEMTGHANFAEHGQDLVCAGVTAVVFGA VNAVIVLAGFEPLLDIGEDGGYFYFEFPESLDPEARQKAQLLIEGMIVSLETIERDYK DNLRVTTNII*" /label="rppA CDS" gene complement(2375755..2376093) /gene="rppA" /locus_tag="BSU_27950" /old_locus_tag="BSU27950" /label="rppA gene" CDS complement(2376096..2376404) /gene="rplU" /locus_tag="BSU_27960" /old_locus_tag="BSU27960" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8223574, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8223574, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L21 (BL20)" /protein_id="NP_390674.1" /db_xref="EnsemblGenomes-Gn:BSU27960" /db_xref="EnsemblGenomes-Tr:CAB14756" /db_xref="GOA:P26908" /db_xref="InterPro:IPR001787" /db_xref="InterPro:IPR018258" /db_xref="InterPro:IPR028909" /db_xref="InterPro:IPR036164" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10333" /db_xref="UniProtKB/Swiss-Prot:P26908" /translation="MYAIIKTGGKQIKVEEGQTVYIEKLAAEAGETVTFEDVLFVGGD NVKVGNPTVEGATVTAKVEKQGRAKKITVFRYKPKKNVHKKQGHRQPYTKVTIEKINA *" /label="rplU CDS" gene complement(2376096..2376404) /gene="rplU" /locus_tag="BSU_27960" /old_locus_tag="BSU27960" /label="rplU gene" misc_RNA complement(2376418..2376493) /gene="ldlU" /locus_tag="BSU_misc_RNA_43" /product="ribosomal protein L21 leader mRNA sequence" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27381917" /label="ldlU RNA" gene complement(2376418..2376493) /gene="ldlU" /locus_tag="BSU_misc_RNA_43" /label="ldlU gene" promotor_-10 complement(2376505..2376524) /Source="Nicolas_upshift_promotors" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2376525) /Source="Nicolas_upshifts" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2376538..2376545) /Source="Nicolas_upshift_promotors" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2376551..2377417) /gene="spoIVFB" /locus_tag="BSU_27970" /old_locus_tag="BSU27970" /EC_number="3.4.24.-" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 26953342, 29180425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 26953342, 29180425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane metalloprotease [proteolysis of pro-sigma(K)]" /protein_id="NP_390675.1" /db_xref="EnsemblGenomes-Gn:BSU27970" /db_xref="EnsemblGenomes-Tr:CAB14757" /db_xref="GOA:P26937" /db_xref="InterPro:IPR008915" /db_xref="SubtiList:BG10332" /db_xref="UniProtKB/Swiss-Prot:P26937" /translation="MNKWLDLILKIHVHPFLWIIAALGLLTGHMKALLCLLLIVLIHE LGHAALAVFFSWRIKRVFLLPFGGTVEVEEHGNRPLKEEFAVIIAGPLQHIWLQFAAW MLAEVSVIHQHTFELFTFYNLSILFVNLLPIWPLDGGKLLFLLFSKQLPFQKAHRLNL KTSLCFCLLLGCWVLFVIPLQISAWVLFVFLAVSLFEEYRQRHYIHVRFLLERYYGKN RELEKLLPLTVKAEDKVYHVMAEFKRGCKHPIIIEKSGQKLSQLDENEVLHAYFADKR TNSSMEELLLPY*" /label="spoIVFB CDS" gene complement(2376551..2377417) /gene="spoIVFB" /locus_tag="BSU_27970" /old_locus_tag="BSU27970" /label="spoIVFB gene" CDS complement(2377410..2378204) /gene="spoIVFA" /locus_tag="BSU_27980" /old_locus_tag="BSU27980" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 17824930, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 17824930, 22882546; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of SpoIVFB (stage IV sporulation)" /protein_id="NP_390676.1" /db_xref="EnsemblGenomes-Gn:BSU27980" /db_xref="EnsemblGenomes-Tr:CAB14758" /db_xref="GOA:P26936" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="SubtiList:BG10331" /db_xref="UniProtKB/Swiss-Prot:P26936" /translation="MSHRADEIRKRLEKRRKQLSGSKRFSTQTVSEKQKPPSWVMVTD QEKHGTLPVYEDNMPTFNGKHPLVKTDSIILKCLLSACLVLVSAIAYKTNIGPVSQIK PAVAKTFETEFQFASASHWFETKFGNPLAFLAPEHKNKEQQIEVGKDLIAPASGKVQQ DFQDNGEGIKVETSSDKIDSVKEGYVVEVSKDSQTGLTVKVQHADNTYSIYGELKDVD VALYDFVDKGKKLGSIKLDDHNKGVYYFAMKDGDKFIDPIQVISFE*" /label="spoIVFA CDS" gene complement(2377410..2378204) /gene="spoIVFA" /locus_tag="BSU_27980" /old_locus_tag="BSU27980" /label="spoIVFA gene" downshifts 2378207 /Source="Nicolas_upshifts" /id="D1432" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="1.00279" /MaxDrop="2.6024" /score="-6.66807377" /energy="-6.9" /TU="NA" /idTUdmin="U2165" /TUdmin="-131" /isTUend="FALSE" /label="downshifts" promotor_no_box 2378213..2378313 /Source="Nicolas_upshift_promotors" /id="U2165" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.536463536463537" /psig="0.242757242757243" /xcortree=281 /SigmaFactorBS="tcctttgcattcgttgggtttgtacatcatatgtcttgtcca tggcaaatattcggtttagtcaagaacaaagcaggcaaaaacaaaaaaaacctgacac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(2378228..2378246) /Source="Nicolas_upshift_promotors" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="promotor_-10" upshifts complement(2378239) /Source="Nicolas_upshifts" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="upshifts" promotor_-35 complement(2378262..2378267) /Source="Nicolas_upshift_promotors" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="promotor_-35" upshifts 2378273 /Source="Nicolas_upshifts" /id="U2165" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.536463536463537" /psig="0.242757242757243" /xcortree=281 /SigmaFactorBS="tcctttgcattcgttgggtttgtacatcatatgtcttgtcca tggcaaatattcggtttagtcaagaacaaagcaggcaaaaacaaaaaaaacctgacac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2378316 /Source="Nicolas_upshifts" /id="D1433" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="1.68429" /MaxDrop="7.01891" /score="-6.66807377" /energy="-6.9" /TU="U2165" /idTUdmin="U2165" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts complement(2378351) /Source="Nicolas_upshifts" /id="D1434" /incds=0 /nref=236 /ntot=262 /MaxReadThrough="2.68001" /MaxDrop="5.80551" /score="40.3102023" /energy="-12.6" /TU="U2166" /idTUdmin="U2167" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(2378354..2379160) /gene="minD" /locus_tag="BSU_27990" /old_locus_tag="BSU27990" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11886553, 12426398, 12492852, 12492861, 16322744, 16885474, 17513368, 19019154, 28674273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886553, 12426398, 12492852, 12492861, 16322744, 16885474, 17513368, 19019154, 28674273; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="ATPase activator of MinC" /protein_id="NP_390677.1" /db_xref="EnsemblGenomes-Gn:BSU27990" /db_xref="EnsemblGenomes-Tr:CAB14759" /db_xref="GOA:Q01464" /db_xref="InterPro:IPR002586" /db_xref="InterPro:IPR010223" /db_xref="InterPro:IPR025501" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10330" /db_xref="UniProtKB/Swiss-Prot:Q01464" /translation="MGEAIVITSGKGGVGKTTTSANLGTALAILGKRVCLVDTDIGLR NLDVVMGLENRIIYDLVDVVEGRCKMHQALVKDKRFDDLLYLMPAAQTSDKTAVAPEQ IKNMVQELKQEFDYVIIDCPAGIEQGYKNAVSGADKAIVVTTPEISAVRDADRIIGLL EQEENIEPPRLVVNRIRNHLMKNGDTMDIDEIVQHLSIDLLGIVADDDEVIKASNHGE PIAMDPKNRASIAYRNIARRILGESVPLQVLEEQNKGMMAKIKSFFGVRS*" /label="minD CDS" gene complement(2378354..2379160) /gene="minD" /locus_tag="BSU_27990" /old_locus_tag="BSU27990" /label="minD gene" CDS complement(2379162..2379842) /gene="minC" /locus_tag="BSU_28000" /old_locus_tag="BSU28000" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10411726, 12426398, 12446561, 15317782, 16322744, 17326815, 19141479, 20352045, 22720735, 24366721" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411726, 12426398, 12446561, 15317782, 16322744, 17326815, 19141479, 20352045, 22720735, 24366721; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division regulator (septum placement)" /protein_id="NP_390678.1" /db_xref="EnsemblGenomes-Gn:BSU28000" /db_xref="EnsemblGenomes-Tr:CAB14760" /db_xref="GOA:Q01463" /db_xref="InterPro:IPR005526" /db_xref="InterPro:IPR013033" /db_xref="InterPro:IPR036145" /db_xref="PDB:2M4I" /db_xref="SubtiList:BG10329" /db_xref="UniProtKB/Swiss-Prot:Q01463" /translation="MKTKKQQYVTIKGTKNGLTLHLDDACSFDELLDGLQNMLSIEQY TDGKGQKISVHVKLGNRFLYKEQEEQLTELIASKKDLFVHSIDSEVITKKEAQQIREE AEIISVSKIVRSGQVLQVKGDLLLIGDVNPGGTVRAGGNIFVLGSLKGIAHAGFNGNN QAVIAASEMLPTQLRINHVLNRSPDHIQKGNEMECAYLDTDGNMVIERLQHLAHLRPD LTRLEGGM*" /label="minC CDS" gene complement(2379162..2379842) /gene="minC" /locus_tag="BSU_28000" /old_locus_tag="BSU28000" /label="minC gene" CDS complement(2379895..2380413) /gene="mreD" /locus_tag="BSU_28010" /old_locus_tag="BSU28010" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16101995, 16850406, 18156271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16101995, 16850406, 18156271; Product type s: structure" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390679.1" /db_xref="EnsemblGenomes-Gn:BSU28010" /db_xref="EnsemblGenomes-Tr:CAB14761" /db_xref="GOA:Q01467" /db_xref="InterPro:IPR007227" /db_xref="SubtiList:BG10328" /db_xref="UniProtKB/Swiss-Prot:Q01467" /translation="MKRFLLPFVMMLVFSAESIFTDLVHFPFVTDDQVLAPRFLMLVL IFMSAFINQKHAMIYGFIFGFLYDMNYTSLLGVYMFGFAGLCYLASKAFKVLHTNAFV VILIAVLAVCLLEFYVFGIQSLIHKDIMTFNGFVLDRFIPTILLNIAAALILVLPFRL FFMSLKKELRDE*" /label="mreD CDS" gene complement(2379895..2380413) /gene="mreD" /locus_tag="BSU_28010" /old_locus_tag="BSU28010" /label="mreD gene" CDS complement(2380410..2381282) /gene="mreC" /locus_tag="BSU_28020" /old_locus_tag="BSU28020" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16101995, 16850406, 17427287, 20623345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16101995, 16850406, 17427287, 20623345; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390680.2" /db_xref="EnsemblGenomes-Gn:BSU28020" /db_xref="EnsemblGenomes-Tr:CAB14762" /db_xref="GOA:Q01466" /db_xref="InterPro:IPR007221" /db_xref="SubtiList:BG10327" /db_xref="UniProtKB/Swiss-Prot:Q01466" /translation="MPNKRLMLLLLCIIILVAMIGFSLKGGRNTTWPEKVIGDTTGVF QNIFHTPAEFFAGIFENINDLKNTYKENERLREKLDGQTQYEAKLQELEEENKSLRDE LGHVKSIKDYKPILATVIARSPDNWAKQVTINKGTQQNVAKDMAVTNEKGALIGKIKS SGLNNFTSAVQLLSDTDRNNRVATKISGKKGSKGYGLIEGYDKEKKRLKMTIIERKDK QDVKKGDLIETSGTGGVFPEGLTIGEVTDIESDSYGLTKVAYVKPAADLTDLNNVIVV NRDVPTVDTEEEGS*" /label="mreC CDS" gene complement(2380410..2381282) /gene="mreC" /locus_tag="BSU_28020" /old_locus_tag="BSU28020" /label="mreC gene" CDS complement(2381313..2382326) /gene="mreB" /locus_tag="BSU_28030" /old_locus_tag="BSU28030" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14588250, 15745453, 15922599, 16322744, 16885474, 17064365, 17513368, 22166997, 24550515, 27376153, 28589952" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14588250, 15745453, 15922599, 16322744, 16885474, 17064365, 17513368, 22166997, 24550515, 27376153, 28589952; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390681.2" /db_xref="EnsemblGenomes-Gn:BSU28030" /db_xref="EnsemblGenomes-Tr:CAB14763" /db_xref="GOA:Q01465" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10326" /db_xref="UniProtKB/Swiss-Prot:Q01465" /translation="MFGIGARDLGIDLGTANTLVFVKGKGIVVREPSVVALQTDTKSI VAVGNDAKNMIGRTPGNVVALRPMKDGVIADYETTATMMKYYINQAIKNKGMFARKPY VMVCVPSGITAVEERAVIDATRQAGARDAYPIEEPFAAAIGANLPVWEPTGSMVVDIG GGTTEVAIISLGGIVTSQSIRVAGDEMDDAIINYIRKTYNLMIGDRTAEAIKMEIGSA EAPEESDNMEIRGRDLLTGLPKTIEITGKEISNALRDTVSTIVEAVKSTLEKTPPELA ADIMDRGIVLTGGGALLRNLDKVISEETKMPVLIAEDPLDCVAIGTGKALEHIHLFKG KTR*" /label="mreB CDS" gene complement(2381313..2382326) /gene="mreB" /locus_tag="BSU_28030" /old_locus_tag="BSU28030" /label="mreB gene" upshifts complement(2382367) /Source="Nicolas_upshifts" /id="U2166" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.380619380619381" /psig="0.897102897102897" /xcortree=2535 /SigmaFactorBS="atatttgtaacactttttttttcgtcgaatTAAGCTATAATA GAGTTTAtgagtttttccctttagggtatttttgctttaagaaaggaagatacataca t" /listShort="mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2382379..2382397) /Source="Nicolas_upshift_promotors" /id="U2166" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.380619380619381" /psig="0.897102897102897" /xcortree=2535 /SigmaFactorBS="atatttgtaacactttttttttcgtcgaatTAAGCTATAATA GAGTTTAtgagtttttccctttagggtatttttgctttaagaaaggaagatacataca t" /listShort="mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2382418..2383113) /gene="ysxA" /locus_tag="BSU_28040" /old_locus_tag="BSU28040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10652786, 17434969, 18556794; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved nucleotide-related metabolism protein" /protein_id="NP_390682.1" /db_xref="EnsemblGenomes-Gn:BSU28040" /db_xref="EnsemblGenomes-Tr:CAB14764" /db_xref="GOA:Q02170" /db_xref="InterPro:IPR000445" /db_xref="InterPro:IPR001405" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR020891" /db_xref="InterPro:IPR025657" /db_xref="SubtiList:BG10325" /db_xref="UniProtKB/Swiss-Prot:Q02170" /translation="MVIHDLPLKLKDFPMKEKPRERLLKVGAENLANHELLAILLRTG TKHESVLDLSNRLLRSFDGLRLLKEASVEELSSIPGIGMVKAIQILAAVELGSRIHKL ANEEHFVIRSPEDGANLVMEDMRFLTQEHFVCLYLNTKNQVIHKRTVFIGSLNSSIVH PREVFKEAFKRSAASFICVHNHPSGDPTPSREDIEVTRRLFECGNLIGIELLDHLVIG DKKFVSLKEKGYL*" /label="ysxA CDS" gene complement(2382418..2383113) /gene="ysxA" /locus_tag="BSU_28040" /old_locus_tag="BSU28040" /label="ysxA gene" CDS complement(2383150..2383719) /gene="maf" /locus_tag="BSU_28050" /old_locus_tag="BSU28050" /EC_number="3.6.1.9" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10841541, 16216582, 21564336, 24210219" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10841541, 16216582, 21564336, 24210219; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nucleoside triphosphate pyrophosphatase; septum formation DNA-binding protein (multicopy associated filamentation)" /protein_id="NP_390683.1" /db_xref="EnsemblGenomes-Gn:BSU28050" /db_xref="EnsemblGenomes-Tr:CAB14765" /db_xref="GOA:Q02169" /db_xref="InterPro:IPR003697" /db_xref="InterPro:IPR029001" /db_xref="PDB:1EX2" /db_xref="PDB:1EXC" /db_xref="PDB:4HEB" /db_xref="SubtiList:BG10324" /db_xref="UniProtKB/Swiss-Prot:Q02169" /translation="MTKPLILASQSPRRKELLDLLQLPYSIIVSEVEEKLNRNFSPEE NVQWLAKQKAKAVADLHPHAIVIGADTMVCLDGECLGKPQDQEEAASMLRRLSGRSHS VITAVSIQAENHSETFYDKTEVAFWSLSEEEIWTYIETKEPMDKAGAYGIQGRGALFV KKIDGDYYSVMGLPISKTMRALRHFDIRA*" /label="maf CDS" gene complement(2383150..2383719) /gene="maf" /locus_tag="BSU_28050" /old_locus_tag="BSU28050" /label="maf gene" promotor_-10 complement(2383571..2383586) /Source="Nicolas_upshift_promotors" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2383580) /Source="Nicolas_upshifts" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2383599..2383608) /Source="Nicolas_upshift_promotors" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2383758..2383777) /Source="Nicolas_upshift_promotors" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2383774) /Source="Nicolas_upshifts" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2383791..2383797) /Source="Nicolas_upshift_promotors" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2383870) /Source="Nicolas_upshifts" /id="D1435" /incds=0 /nref=41 /ntot=100 /MaxReadThrough="1.92542" /MaxDrop="5.77117" /score="8.94061802" /energy="-7.4" /TU="NA" /idTUdmin="U2169" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2383872..2384870) /gene="spoIIB" /locus_tag="BSU_28060" /old_locus_tag="BSU28060" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16959571, 17376078, 22720735, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16959571, 17376078, 22720735, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spatial and temporal regulator of the dissolution of septal peptidoglycan during engulfment (stage II sporulation)" /protein_id="NP_390684.1" /db_xref="EnsemblGenomes-Gn:BSU28060" /db_xref="EnsemblGenomes-Tr:CAB14766" /db_xref="GOA:P37575" /db_xref="InterPro:IPR007730" /db_xref="InterPro:IPR036680" /db_xref="SubtiList:BG10912" /db_xref="UniProtKB/Swiss-Prot:P37575" /translation="MKKRKNKKNSKAAEKALKVTINGKEETVYEQETPETEANKSMTF SNWEEKRQAEQEVAASQEHPDEDEFNWDSEEDKVFKEDPKVVPPFQKKKTKLYAKGKT GAAKPVKRVAATIAFAAVIGTGLGLFALNISGNKEASAPASLEDSLGSQTAKAGDTSA DKQTSGAEKQAAQTEGTYKTYAVQAGKFSNEKGAETLTEQLTEKGYSAVSLSKDDGYT YVIAGLASEKEVSQQLGQVLIDSDFEAWGGKELSLSIESDMTDSFKETAELAAKAILD EDITKASVEKIEKSLGETKASETGEKKAILQALKELEDPSAEAGWKAQQELLAVVK*" /label="spoIIB CDS" gene complement(2383872..2384870) /gene="spoIIB" /locus_tag="BSU_28060" /old_locus_tag="BSU28060" /label="spoIIB gene" promotor_-10 complement(2384917..2384936) /Source="Nicolas_upshift_promotors" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2384925) /Source="Nicolas_upshifts" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2384948..2384955) /Source="Nicolas_upshift_promotors" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2384993) /Source="Nicolas_upshifts" /id="D1436" /incds=0 /nref=1 /ntot=56 /MaxReadThrough="3.18314" /MaxDrop="2.89774" /score="11.209969" /energy="-7.6" /TU="U2170" /idTUdmin="U2170" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" CDS complement(2385004..2385750) /gene="comC" /locus_tag="BSU_28070" /old_locus_tag="BSU28070" /EC_number="3.4.23.43" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2553669, 9723928, 15849754, 16751195, 16850406, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2553669, 9723928, 15849754, 16751195, 16850406, 16751195; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="membrane prepilin peptidase" /protein_id="NP_390685.2" /db_xref="EnsemblGenomes-Gn:BSU28070" /db_xref="EnsemblGenomes-Tr:CAB14767" /db_xref="GOA:P15378" /db_xref="InterPro:IPR000045" /db_xref="InterPro:IPR010627" /db_xref="SubtiList:BG10323" /db_xref="UniProtKB/Swiss-Prot:P15378" /translation="MLSILFIFGLILGSFYYTAGCRIPLHLSIIAPRSSCPFCRRTLT PAELIPILSFLFQKGKCKSCGHRISFMYPAAELVTACLFAAAGIRFGISLELFPAVVF ISLLIIVAVTDIHFMLIPNRILIFFLPFLAAARLISPLDSWYAGLLGAAAGFLFLAVI AAITHGGVGGGDIKLFAVIGFVLGVKMLAAAFFFSVLIGALYGAAAVLTGRLAKRQPL PFAPAIAAGSILAYLYGDSIISFYIKMALG*" /label="comC CDS" gene complement(2385004..2385750) /gene="comC" /locus_tag="BSU_28070" /old_locus_tag="BSU28070" /label="comC gene" promotor_-10 complement(2385778..2385797) /Source="Nicolas_upshift_promotors" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2385785) /Source="Nicolas_upshifts" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2385812..2385819) /Source="Nicolas_upshift_promotors" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2385890..2387182) /gene="folC" /locus_tag="BSU_28080" /old_locus_tag="BSU28080" /EC_number="6.3.2.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2105929, 2985605, 3040739, 6994831, 9098041, 15705579, 22720735, 26443588; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="folyl-polyglutamate synthase" /protein_id="NP_390686.1" /db_xref="EnsemblGenomes-Gn:BSU28080" /db_xref="EnsemblGenomes-Tr:CAB14768" /db_xref="GOA:Q05865" /db_xref="InterPro:IPR001645" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR018109" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10322" /db_xref="UniProtKB/Swiss-Prot:Q05865" /translation="MFTAYQDARSWIHGRLKFGVKPGLGRMKQLMARLGHPEKKIRAF HVAGTNGKGSTVAFIRSMLQEAGYTVGTFTSPYIITFNERISVNGIPISDEEWTALVN QMKPHVEALDQTEYGQPTEFEIMTACAFLYFAEFHKVDFVIFETGLGGRFDSTNVVEP LLTVITSIGHDHMNILGNTIEEIAGEKAGIIKEGIPIVTAVTQPEALQVIRHEAERHA APFQSLHDACVIFNEEALPAGEQFSFKTEEKCYEDIRTSLIGTHQRQNAALSILAAEW LNKENIAHISDEALRSGLVKAAWPGRLELVQEHPPVYLDGAHNEEGVEKLAETMKQRF ANSRISVVFSALKDKPYQNMIKRLETIAHAIHFASFDFPRASLAKDLYDASEISNKSW SEDPDDVIKFIESKKGSNEIVLITGSLYFISDIRKRLK*" /label="folC CDS" gene complement(2385890..2387182) /gene="folC" /locus_tag="BSU_28080" /old_locus_tag="BSU28080" /label="folC gene" downshifts complement(2385895) /Source="Nicolas_upshifts" /id="D1437" /incds=0 /nref=1 /ntot=121 /MaxReadThrough="1.66565" /MaxDrop="3.18428" /score="24.7086033" /energy="-14.3" /TU="NA" /idTUdmin="U2171" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2387183..2387241) /Source="Nicolas_S_feature" /locus_tag="new_2866605_2866663_c" /HighExp="S0, LBGexp, G150, MG 45, G135, G180, Gly, Oxctl, M0t45, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S1060" CDS complement(2387242..2389884) /gene="valS" /locus_tag="BSU_28090" /old_locus_tag="BSU28090" /EC_number="6.1.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9098041, 11114335, 25310979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098041, 11114335, 25310979; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="valyl-tRNA synthetase" /protein_id="NP_390687.2" /db_xref="EnsemblGenomes-Gn:BSU28090" /db_xref="EnsemblGenomes-Tr:CAB14769" /db_xref="GOA:Q05873" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002303" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR019499" /db_xref="InterPro:IPR033705" /db_xref="InterPro:IPR037118" /db_xref="SubtiList:BG10321" /db_xref="UniProtKB/Swiss-Prot:Q05873" /translation="METNEQTMPTKYDPAAVEKDRYDFWLKGKFFEAGSDQTKEPYSV VIPPPNVTGRLHLGHAWDTTLQDIVTRMKRMQGYDVLWLPGMDHAGIATQAKVEAKLR EEGKSRYDLGREKFLEETWKWKEEYADFIRSQWAKLGLGLDYSRERFTLDEGLSKAVR EVFVKLYEKGLIYRGEYIINWDPATKTALSDIEVIYKDVQGAFYHMSYPLADGSGSIE IATTRPETMLGDTAVAVHPEDERYKHLIGKTVILPIVNREIPIVGDDYVDMEFGSGAV KITPAHDPNDFELGNRHNLERILVMNEDGTMNENALQYQGMDRFECRKKLVKDLQEAG VLFKIEDHMHSVGHSERSGAVVEPYLSTQWFVRMQPLADAAIELQKKEEKVNFVPDRF EKTYLHWMENIRDWCISRQLWWGHRIPAWYHKETGELYVGLEAPEDSENWEQDTDVLD TWFSSALWPFSTMGWPDVTAEDFKRYYPTDVLVTGYDIIFFWVSRMIFQGIEFTGERP FKDVLIHGLIRDEQGRKMSKSLGNGVDPMDVIDKYGADSLRYFLATGSSPGQDLRFSY EKVESTWNFANKIWNASRFALMNMDGMTYDELDLSGEKSVADKWILTRLNETIEHVTQ LADRYEFGEVGRHLYNFIWDDFCDWYIEMAKLPLYGEDEAAKKTTRSILAYVLDQTMR LLHPFMPFLTEEIWQHLPHQGESITVSQWPAVVPEHTDTEAAADMKLLVELIRSVRNI RSEVNTPMSKQVELYIKTSTDEIASRLEANRSYVERFTNPSVLKIGTDIEAVDKAMTA VVSGAEVILPLEGLINIDEEIARLQKEFDKLTKEVERVQKKLGNEGFMKKAPAHVIDE EREKEKDYVAKRDAVQKRMAELKG*" /label="valS CDS" gene complement(2387242..2389884) /gene="valS" /locus_tag="BSU_28090" /old_locus_tag="BSU28090" /label="valS gene" S_feature complement(2389885..2389943) /Source="Nicolas_S_feature" /locus_tag="new_2869307_2869365_c" /HighExp="G150, G180, LBGexp, Oxctl, G135, dia0, HPh, Lbexp, Paraq, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigEF" /TUshortPSig="1, 0.012, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1061" misc_RNA complement(2389944..2390166) /gene="tboV" /locus_tag="BSU_misc_RNA_44" /product="T-box riboswitch specific of valine tRNA" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboV RNA" gene complement(2389944..2390166) /gene="tboV" /locus_tag="BSU_misc_RNA_44" /label="tboV gene" downshifts complement(2389987) /Source="Nicolas_upshifts" /id="D1438" /incds=0 /nref=9 /ntot=27 /MaxReadThrough="6.76593" /MaxDrop="4.53149" /score="23.9897385" /energy="-20" /TU="U2171,U2173,U2176" /idTUdmin="U2176" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2390195..2390214) /Source="Nicolas_upshift_promotors" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2390207) /Source="Nicolas_upshifts" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2390209..2390317) /Source="Nicolas_S_feature" /locus_tag="new_2869631_2869739_c" /HighExp="S8, S6, S7, S5, B36, LoTm, S4, S3, BT, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigEF" /TUshortPSig="0.012, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1062" promotor_-35 complement(2390229..2390234) /Source="Nicolas_upshift_promotors" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2390271..2390280 /Source="Nicolas_upshift_promotors" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2390293..2390312 /Source="Nicolas_upshift_promotors" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2390294 /Source="Nicolas_upshifts" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2390310..2390324) /Source="Nicolas_upshift_promotors" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2390317) /Source="Nicolas_upshifts" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2390332..2390336) /Source="Nicolas_upshift_promotors" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2390332..2390523 /gene="yszA" /locus_tag="BSU_28099" /old_locus_tag="BSU28099" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097770.1" /db_xref="EnsemblGenomes-Gn:BSU28099" /db_xref="EnsemblGenomes-Tr:CAX52676" /db_xref="GOA:C0H465" /db_xref="UniProtKB/Swiss-Prot:C0H465" /translation="MKKRFSSYSLPPWVRQIRLVSAQVIIPITIFQGIRTIFFPTTFD VLLLAILIFLACALHLEWI*" /label="yszA CDS" gene 2390332..2390523 /gene="yszA" /locus_tag="BSU_28099" /old_locus_tag="BSU28099" /label="yszA gene" CDS complement(2390542..2391567) /gene="cotN" /locus_tag="BSU_28100" /old_locus_tag="BSU28100" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16371471, 16390444, 22091839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16371471, 16390444, 22091839; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390688.1" /db_xref="EnsemblGenomes-Gn:BSU28100" /db_xref="EnsemblGenomes-Tr:CAB14770" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014253" /db_xref="SubtiList:BG10347" /db_xref="UniProtKB/Swiss-Prot:P37964" /translation="MEDTQSVLQEYGLTAQFIEPVSPLVWKVYTDYGIFALKKLKEGR GKHFTDHMVAIEEKGFRSFVPVYRTNSGEFFSAGIQYGDIYYLMPWLQFDQEEERDQK HAYLFRETARLHERTAQELKVRRDEIERYYGQTKKKWEQDKIFYEQFVDRAEKEWYLS PFELQAITYFSETISAVNFALERLEDWYESAKEKDVSRVVMNHGSLSIHHFLYNDAGT GYFTNFERASVGPPQNDLLGFYTKMFRGFPKACPECVEWFYGYTKSFPLREAEVSLFL SYMAYPAAMYKVLNGYQTGKRQHEKEECTQLLKAYWQMKNIEPFVMKIHQIEQEKKFQ AENESTS*" /label="cotN CDS" gene complement(2390542..2391567) /gene="cotN" /locus_tag="BSU_28100" /old_locus_tag="BSU28100" /label="cotN gene" downshifts complement(2390572) /Source="Nicolas_upshifts" /id="D1439" /incds=0 /nref=23 /ntot=70 /MaxReadThrough="4.44965" /MaxDrop="6.68961" /score="-7.46388093" /energy="-12.1" /TU="U2176" /idTUdmin="U2176" /TUdmin="-1311" /isTUend="FALSE" /label="downshifts" CDS complement(2391600..2393327) /gene="spoVID" /locus_tag="BSU_28110" /old_locus_tag="BSU28110" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11325931, 16371471, 16950916, 22773792, 23178679" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11325931, 16371471, 16950916, 22773792, 23178679; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="morphogenetic spore protein (stage VI sporulation)" /protein_id="NP_390689.1" /db_xref="EnsemblGenomes-Gn:BSU28110" /db_xref="EnsemblGenomes-Tr:CAB14771" /db_xref="GOA:P37963" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG10346" /db_xref="UniProtKB/Swiss-Prot:P37963" /translation="MPQNHRLQFSVEESICFQKGQEVSELLSISLDPDIRVQEVNDYV SIIGSLELTGEYNIDQNKHTEEIYTDKRFVEQVRKREDGSAELTHCFPVDITIPKNKV SHLQDVFVFIDAFDYQLTDSRILTIQADLAIEGLLDDTQDKEPEIPLYEAPAAFREEE LSEPPAHSVVEEPGASSAEEAVLQHEPPAEPPELFISKAGLREELETEKAESEPPESV ASEPEAREDVKEEEESEELAVPETEVRAESETEESEPEPDPSEIEIQEIVKAKKETAE PAAAIADVREEADSPAETELREHVGAEESPALEAELHSETVIAKEKEETTVSPNHEYA LRQEAQNEEAAQSDQADPALCQEEAEPDEALESVSEAALSIEDSRETASAVYMENDNA DLHFHFNQKTSSEEASQEELPEPAYRTFLPEQEEEDSFYSAPKLLEEEEQEEESFEIE VRKTPSAEEPKEETPFQSFQLPESSETERKETDAVPRVAPAAETKEPQTKESDNSLYL TKLFTKEADEFSRMKICIVQQEDTIERLCERYEITSQQLIRMNSLALDDELKAGQILY IPQYKNSHA*" /label="spoVID CDS" gene complement(2391600..2393327) /gene="spoVID" /locus_tag="BSU_28110" /old_locus_tag="BSU28110" /label="spoVID gene" promotor_-35 2392929..2392932 /Source="Nicolas_upshift_promotors" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2392948..2392967 /Source="Nicolas_upshift_promotors" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2392954 /Source="Nicolas_upshifts" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2393323..2393327 /Source="Nicolas_upshift_promotors" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2393336..2393350 /Source="Nicolas_upshift_promotors" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2393350 /Source="Nicolas_upshifts" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2393365..2393383) /Source="Nicolas_upshift_promotors" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="promotor_-10" upshifts complement(2393381) /Source="Nicolas_upshifts" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="upshifts" promotor_-35 complement(2393399..2393404) /Source="Nicolas_upshift_promotors" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="promotor_-35" CDS complement(2393458..2394750) /gene="hemL" /locus_tag="BSU_28120" /old_locus_tag="BSU28120" /EC_number="5.4.3.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1672867, 12029044, 15802251, 16682782, 20946885, 27303897" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1672867, 12029044, 15802251, 16682782, 20946885, 27303897; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glutamate-1-semialdehyde 2,1-aminomutase" /protein_id="NP_390690.1" /db_xref="EnsemblGenomes-Gn:BSU28120" /db_xref="EnsemblGenomes-Tr:CAB14772" /db_xref="GOA:P30949" /db_xref="InterPro:IPR004639" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="PDB:3BS8" /db_xref="SubtiList:BG10345" /db_xref="UniProtKB/Swiss-Prot:P30949" /translation="MRSYEKSKTAFKEAQKLMPGGVNSPVRAFKSVDMDPIFMERGKG SKIFDIDGNEYIDYVLSWGPLILGHTNDRVVESLKKVAEYGTSFGAPTEVENELAKLV IDRVPSVEIVRMVSSGTEATMSALRLARGYTGRNKILKFEGCYHGHGDSLLIKAGSGV ATLGLPDSPGVPEGIAKNTITVPYNDLESVKLAFQQFGEDIAGVIVEPVAGNMGVVPP QEGFLQGLRDITEQYGSLLIFDEVMTGFRVDYNCAQGYFGVTPDLTCLGKVIGGGLPV GAYGGKAEIMEQIAPSGPIYQAGTLSGNPLAMTAGLETLKQLTPESYKNFIKKGDRLE EGISKTAGAHGIPHTFNRAGSMIGFFFTNEPVINYETAKSSDLKLFASYYKGMANEGV FLPPSQFEGLFLSTAHTDEDIENTIQAAEKVFAEISRR*" /label="hemL CDS" gene complement(2393458..2394750) /gene="hemL" /locus_tag="BSU_28120" /old_locus_tag="BSU28120" /label="hemL gene" downshifts complement(2393475) /Source="Nicolas_upshifts" /id="D1440" /incds=0 /nref=144 /ntot=397 /MaxReadThrough="3.40168" /MaxDrop="7.29251" /score="3.77738386" /energy="-10.6" /TU="NA" /idTUdmin="U2177" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" CDS complement(2394780..2395754) /gene="hemB" /locus_tag="BSU_28130" /old_locus_tag="BSU28130" /EC_number="4.2.1.24" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110138, 12029044, 15802251, 20823524, 24598743" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110138, 12029044, 15802251, 20823524, 24598743; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="delta-aminolevulinic acid dehydratase (porphobilinogen synthase)" /protein_id="NP_390691.1" /db_xref="EnsemblGenomes-Gn:BSU28130" /db_xref="EnsemblGenomes-Tr:CAB14773" /db_xref="GOA:P30950" /db_xref="InterPro:IPR001731" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR030656" /db_xref="SubtiList:BG10344" /db_xref="UniProtKB/Swiss-Prot:P30950" /translation="MSQSFNRHRRLRTSKAMREMVKETRLHPSDFIYPIFVVEGLEGK KAVPSMPDVHHVSLDLLKDEVAELVKLGIQSVIVFGIPEEKDDCGTQAYHDHGIVQKA ITEIKEHFPEMVVVADTCLCEYTDHGHCGLVKDGVILNDESLELLAQTAVSQAKAGAD IIAPSNMMDGFVTVIREALDKEGFVNIPIMSYAVKYSSEFYGPFRDAANSTPQFGDRK TYQMDPANRMEALREAQSDVEEGADFLIVKPSLSYMDIMRDVKNEFTLPLVAYNVSGE YSMVKAAAQNGWIKEKEIVLEILTSMKRAGADLIITYHAKDAAKWLAE*" /label="hemB CDS" gene complement(2394780..2395754) /gene="hemB" /locus_tag="BSU_28130" /old_locus_tag="BSU28130" /label="hemB gene" CDS complement(2395751..2396539) /gene="hemD" /locus_tag="BSU_28140" /old_locus_tag="BSU28140" /EC_number="4.2.1.75" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1672867, 2110138, 7628476, 12029044, 12196144, 15802251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1672867, 2110138, 7628476, 12029044, 12196144, 15802251; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III cosynthase" /protein_id="NP_390692.1" /db_xref="EnsemblGenomes-Gn:BSU28140" /db_xref="EnsemblGenomes-Tr:CAB14774" /db_xref="GOA:P21248" /db_xref="InterPro:IPR003754" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG10343" /db_xref="UniProtKB/Swiss-Prot:P21248" /translation="MENDFPLKGKTVLVTRNKAQAASFQQKVEALGGKAVLTSLITFR RALPNDVAEQVREDLAAPGWLVFTSVNGADFFFSYLKENQLILPAHKKIAAVGEKTAR RLKMHNVSVDVMPQEYIAEQLADALKQHAEPGETITVMKGNLSRDVIKQELVPLGFEV KEWVLYETIPDEEGIEALKDAAGQYSFDYVTFTSSSTVHTFMHVLGEELKKWKANGTA CISIGPLTNDALLTYGITSHTPDTFTIDGMLELMCSMSREEERI*" /label="hemD CDS" gene complement(2395751..2396539) /gene="hemD" /locus_tag="BSU_28140" /old_locus_tag="BSU28140" /label="hemD gene" CDS complement(2396529..2397473) /gene="hemC" /locus_tag="BSU_28150" /old_locus_tag="BSU28150" /EC_number="2.5.1.61" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110138, 9058548, 12029044, 15802251, 23908040, 24598743" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110138, 9058548, 12029044, 15802251, 23908040, 24598743; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="porphobilinogen deaminase (hydroxymethylbilane synthase)" /protein_id="NP_390693.1" /db_xref="EnsemblGenomes-Gn:BSU28150" /db_xref="EnsemblGenomes-Tr:CAB14775" /db_xref="GOA:P16616" /db_xref="InterPro:IPR000860" /db_xref="InterPro:IPR022417" /db_xref="InterPro:IPR022418" /db_xref="InterPro:IPR022419" /db_xref="InterPro:IPR036803" /db_xref="SubtiList:BG10342" /db_xref="UniProtKB/Swiss-Prot:P16616" /translation="MMRTIKVGSRRSKLAMTQTKWVIQKLKEINPSFAFEIKEIVTKG DRIVDVTLSKVGGKGLFVKEIEQALLNEEIDMAVHSMKDMPAVLPEGLVIGCIPERED PRDALISKNRVKLSEMKKGAVIGTSSLRRSAQLLIERPDLTIKWIRGNIDTRLQKLET EDYDAIILAAAGLSRMGWKQDVVTEFLEPERCLPAVGQGALAIECRESDEELLALFSQ FTDEYTKRTVLAERAFLNAMEGGCQVPIAGYSVLNGQDEIEMTGLVASPDGKIIFKET VTGNDPEEVGKRCAALMADKGAKDLIDRVKRELDEDGK*" /label="hemC CDS" gene complement(2396529..2397473) /gene="hemC" /locus_tag="BSU_28150" /old_locus_tag="BSU28150" /label="hemC gene" CDS complement(2397506..2398336) /gene="hemX" /locus_tag="BSU_28160" /old_locus_tag="BSU28160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8012594, 12029044, 15802251, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8012594, 12029044, 15802251, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="negative effector of the concentration of glutamyl-tRNA reductase HemA" /protein_id="NP_390694.2" /db_xref="EnsemblGenomes-Gn:BSU28160" /db_xref="EnsemblGenomes-Tr:CAB14776" /db_xref="GOA:P16645" /db_xref="InterPro:IPR002541" /db_xref="SubtiList:BG10341" /db_xref="UniProtKB/Swiss-Prot:P16645" /translation="MIDTAMARLNEGTIVIYALSVLFYFIDFLQHNRKAGKMAFWLLS IVWTLQTVYLAYFMWVTGRFPVLNVTEALYFYAWVLVTLSLVLTKLLRVDFIVFFTNV IGFSMIAIHTFSPTEQQSAAFSGQLVSELLVIHITMAILSYGAFSLSFVFSVLYMFQY HLLKKKKWGKWLLRIEDLSKLDYMAYVLNVIGVPMLLLSLILGVIWAYVSLETLYWFD AKVLGSFVVLLLYSYYLYIRLIKELQGKVAALWNTACFLVLMINYFLLGSLSQFHWFS *" /label="hemX CDS" gene complement(2397506..2398336) /gene="hemX" /locus_tag="BSU_28160" /old_locus_tag="BSU28160" /label="hemX gene" CDS complement(2398344..2399711) /gene="hemA" /locus_tag="BSU_28170" /old_locus_tag="BSU28170" /EC_number="1.2.1.70" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1536660, 15802251, 1672867, 2490162, 12029044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1536660, 15802251, 1672867, 2490162, 12029044; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA reductase" /protein_id="NP_390695.1" /db_xref="EnsemblGenomes-Gn:BSU28170" /db_xref="EnsemblGenomes-Tr:CAB14777" /db_xref="GOA:P16618" /db_xref="InterPro:IPR000343" /db_xref="InterPro:IPR006151" /db_xref="InterPro:IPR015895" /db_xref="InterPro:IPR015896" /db_xref="InterPro:IPR018214" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036343" /db_xref="InterPro:IPR036453" /db_xref="SubtiList:BG10340" /db_xref="UniProtKB/Swiss-Prot:P16618" /translation="MHILVVGVDYKSAPIEIREKVSFQPNELAEAMVQLKEEKSILEN IIVSTCNRTEIYAVVDQLHTGRYYIKKFLADWFQLSKEELSPFLTFYESDAAVEHLFR VACGLDSMVIGETQILGQVRDSFKTAQQEKTIGTIFNELFKQAVTVGKRTHAETDIGS NAVSVSYAAVELAKKIFGNLSSKHILILGAGKMGELAAENLHGQGIGKVTVINRTYLK AKELADRFSGEARSLNQLESALAEADILISSTGASEFVVSKEMMENANKLRKGRPLFM VDIAVPRDLDPALNDLEGVFLYDIDDLEGIVEANMKERRETAEKVELLIEETIVEFKQ WMNTLGVVPVISALREKALAIQSETMDSIERKLPHLSTREKKLLNKHTKSIINQMLRD PILKVKELAADADSEEKLALFMQIFDIEEAAGRQMMKTVESSQKVHSFKKAESKAGFS PLVSE*" /label="hemA CDS" gene complement(2398344..2399711) /gene="hemA" /locus_tag="BSU_28170" /old_locus_tag="BSU28170" /label="hemA gene" misc_feature complement(2399775..2399794) /Source="Nicolas_upshift_promotors" /id="U2177" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig="0.999000999001" /xcortree=1604 /SigmaFactorBS="atatagcataagaattttaaaatctgttcacattttgtgaaa gaaacTATGTTATAATTATTATAAAtaatgagttctatgttagaatgattataaatta a" /listShort="hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2399781) /Source="Nicolas_upshifts" /id="U2177" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig="0.999000999001" /xcortree=1604 /SigmaFactorBS="atatagcataagaattttaaaatctgttcacattttgtgaaa gaaacTATGTTATAATTATTATAAAtaatgagttctatgttagaatgattataaatta a" /listShort="hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2399783..2399872) /Source="Nicolas_S_feature" /locus_tag="new_2879205_2879294_c" /HighExp="dia15, Salt, dia5, Etha, Paraq, H2O2, Diami, Heat, LoTm, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigGF" /TUshortPSig="0.997, 1, 0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1063" misc_feature 2399832..2399851 /Source="Nicolas_upshift_promotors" /id="U2178" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2409 /SigmaFactorBS="aataattataacatagtttctttcacaaaatgtgaacagatt ttaaaattctTATGCTATATTAGAAAAAGCttcagggaaaagaagcattcctattgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2399840 /Source="Nicolas_upshifts" /id="U2178" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2409 /SigmaFactorBS="aataattataacatagtttctttcacaaaatgtgaacagatt ttaaaattctTATGCTATATTAGAAAAAGCttcagggaaaagaagcattcctattgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2399869..2399888) /Source="Nicolas_upshift_promotors" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2399872) /Source="Nicolas_upshifts" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2399874..2400290) /Source="Nicolas_S_feature" /locus_tag="new_2879296_2879712_c" /HighExp="Etha, S5, Gly, S7, S4, S8, S6, H2O2, dia15, G135" /AntisenseName="ysxD" /AntisenseCor="-1.16761021676615E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigGF" /TUshortPSig="1, 0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1064" promotor_-35 complement(2399899..2399907) /Source="Nicolas_upshift_promotors" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2399941..2400438 /gene="ysxD" /locus_tag="BSU_28180" /old_locus_tag="BSU28180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390696.2" /db_xref="EnsemblGenomes-Gn:BSU28180" /db_xref="EnsemblGenomes-Tr:CAB14778" /db_xref="GOA:P40736" /db_xref="SubtiList:BG11068" /db_xref="UniProtKB/Swiss-Prot:P40736" /translation="MKQKSILFPCLLLAASVYAWLESGQAELFSGQDQWPVLLMLLGA AFVYQGKKEAVTPHFFIGLLLFGIGLHFFAKPKWVWWPDDFEMLLFMIGFSLLVSTVQ KKEYVYEAVSMICFSLFLYFFKQIMAWLESAHIPTALLKEYWPFVFIGISLLLLLIKR KKSIR*" /label="ysxD CDS" gene 2399941..2400438 /gene="ysxD" /locus_tag="BSU_28180" /old_locus_tag="BSU28180" /label="ysxD gene" promotor_-10 complement(2400274..2400292) /Source="Nicolas_upshift_promotors" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2400290) /Source="Nicolas_upshifts" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2400292..2400422) /Source="Nicolas_S_feature" /locus_tag="new_2879714_2879844_c" /HighExp="S5, S4, S8, S6, H2O2, S7, Etha, dia15, Diami, G180" /AntisenseName="ysxD" /AntisenseCor="-1.18079537254433E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1065" promotor_-35 complement(2400308..2400314) /Source="Nicolas_upshift_promotors" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2400402..2400413) /Source="Nicolas_upshift_promotors" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="promotor_-10" upshifts complement(2400422) /Source="Nicolas_upshifts" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="upshifts" promotor_-35 complement(2400428..2400434) /Source="Nicolas_upshift_promotors" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="promotor_-35" CDS complement(2400460..2401047) /gene="engB" /locus_tag="BSU_28190" /old_locus_tag="BSU28190" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16997968, 17981968, 21360172, 21636901, 25771857, 26103561, 27484475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16997968, 17981968, 21360172, 21636901, 25771857, 26103561, 27484475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase involved in ribosome 50S subunit assembly(maturation of the central 50S protuberance)" /protein_id="NP_390697.1" /db_xref="EnsemblGenomes-Gn:BSU28190" /db_xref="EnsemblGenomes-Tr:CAB14779" /db_xref="GOA:P38424" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR019987" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030393" /db_xref="PDB:1SUL" /db_xref="PDB:1SVI" /db_xref="PDB:1SVW" /db_xref="SubtiList:BG10339" /db_xref="UniProtKB/Swiss-Prot:P38424" /translation="MKVTKSEIVISAVKPEQYPEGGLPEIALAGRSNVGKSSFINSLI NRKNLARTSSKPGKTQTLNFYIINDELHFVDVPGYGFAKVSKSEREAWGRMIETYITT REELKAVVQIVDLRHAPSNDDVQMYEFLKYYGIPVIVIATKADKIPKGKWDKHAKVVR QTLNIDPEDELILFSSETKKGKDEAWGAIKKMINR*" /label="engB CDS" gene complement(2400460..2401047) /gene="engB" /locus_tag="BSU_28190" /old_locus_tag="BSU28190" /label="engB gene" downshifts complement(2400488) /Source="Nicolas_upshifts" /id="D1441" /incds=0 /nref=78 /ntot=212 /MaxReadThrough="4.03888" /MaxDrop="6.16077" /score="19.8235959" /energy="-13.4" /TU="NA" /idTUdmin="U2182" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2401044..2403368) /gene="lonA" /locus_tag="BSU_28200" /old_locus_tag="BSU28200" /EC_number="3.4.21.53" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10411757, 11325926, 15987505, 18689473, 20600124, 21546913, 25538299, 26677871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411757, 11325926, 15987505, 18689473, 20600124, 21546913, 25538299, 26677871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="class III heat-shock ATP-dependent LonA protease" /protein_id="NP_390698.1" /db_xref="EnsemblGenomes-Gn:BSU28200" /db_xref="EnsemblGenomes-Tr:CAB14780" /db_xref="GOA:P37945" /db_xref="InterPro:IPR003111" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004815" /db_xref="InterPro:IPR008268" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027543" /db_xref="PDB:1X37" /db_xref="PDB:3M65" /db_xref="PDB:3M6A" /db_xref="SubtiList:BG10338" /db_xref="UniProtKB/Swiss-Prot:P37945" /translation="MAEELKRSIPLLPLRGLLVYPTMVLHLDVGRDKSVQALEQAMMH DHMIFLATQQDISIDEPGEDEIFTVGTYTKIKQMLKLPNGTIRVLVEGLKRAHIVKYN EHEDYTSVDIQLIHEDDSKDTEDEALMRTLLDHFDQYIKISKKISAETYAAVTDIEEP GRMADIVASHLPLKLKDKQDILETADVKDRLNKVIDFINNEKEVLEIEKKIGQRVKRS MERTQKEYYLREQMKAIQKELGDKEGKTGEVQTLTEKIEEAGMPDHVKETALKELNRY EKIPSSSAESSVIRNYIDWLVALPWTDETDDKLDLKEAGRLLDEEHHGLEKVKERILE YLAVQKLTKSLKGPILCLAGPPGVGKTSLAKSIAKSLGRKFVRISLGGVRDESEIRGH RRTYVGAMPGRIIQGMKKAGKLNPVFLLDEIDKMSSDFRGDPSSAMLEVLDPEQNSSF SDHYIEETFDLSKVLFIATANNLATIPGPLRDRMEIINIAGYTEIEKLEIVKDHLLPK QIKEHGLKKSNLQLRDQAILDIIRYYTREAGVRSLERQLAAICRKAAKAIVAEERKRI TVTEKNLQDFIGKRIFRYGQAETEDQVGVVTGLAYTTVGGDTLSIEVSLSPGKGKLIL TGKLGDVMRESAQAAFSYVRSKTEELGIEPDFHEKYDIHIHVPEGAVPKDGPSAGITM ATALVSALTGRAVSREVGMTGEITLRGRVLPIGGLKEKALGAHRAGLTTIIAPKDNEK DIEDIPESVREGLTFILASHLDEVLEHALVGEKK*" /label="lonA CDS" gene complement(2401044..2403368) /gene="lonA" /locus_tag="BSU_28200" /old_locus_tag="BSU28200" /label="lonA gene" S_feature complement(2403369..2403480) /Source="Nicolas_S_feature" /locus_tag="new_2882791_2882902_c" /HighExp="Etha, dia15, LBGtran, dia5, Diami, H2O2, LBGexp, Lbexp, LoTm, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.967" /TUlongSig="NA" /TUlongPSig="NA" /label="S1066" promotor_-10 complement(2403465..2403484) /Source="Nicolas_upshift_promotors" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2403480) /Source="Nicolas_upshifts" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2403498..2403505) /Source="Nicolas_upshift_promotors" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2403549..2405207) /gene="lonB" /locus_tag="BSU_28210" /old_locus_tag="BSU28210" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10411757, 11325926, 18689473, 26428922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411757, 11325926, 18689473, 26428922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore-specific ATP-dependent protease LonB" /protein_id="NP_390699.1" /db_xref="EnsemblGenomes-Gn:BSU28210" /db_xref="EnsemblGenomes-Tr:CAB14781" /db_xref="GOA:P42425" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR008268" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014251" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11077" /db_xref="UniProtKB/Swiss-Prot:P42425" /translation="MSWTGIALFIQLFFGIIIGLYFWNLLKNQRTQKVTIDKESKKEM EQLRKMRAISLSEPLSEKVRPKSFKDIVGQEDGIKALKAALCGPNPQHVIVYGPPGVG KTAAARLVLEEAKKHKQSPFKEQAVFVELDATTARFDERGIADPLIGSVHDPIYQGAG AMGQAGIPQPKQGAVTHAHGGVLFIDEIGELHPIQMNKMLKVLEDRKVFLDSAYYSEE NTQIPNHIHDIFQNGLPADFRLIGATTRMPNEIPPAIRSRCLEVFFRELEKDELKTVA KTAADKIEKNISEEGLDLLTSYTRNGREAVNMIQIAAGMAVTENRKDITIEDIEWVIH SSQLTPKHEQKIGVEPQVGIVNGLAVYGPNSGSLLEIEVSVTAAQDKGSINITGIAEE ESIGSQSKSIRRKSMAKGSVENVLTVLRTMGMKPSDYDIHINFPGGIPIDGPSAGIAM AAGIFSAIHKIPIDNTVAMTGEISLNGLVKPIGGVIPKIKAAKQSGAKKVIIPYENQQ AILKQIDGIEIIAVKTFQEVLDEILVNPPTEQKPFHIEINKESV*" /label="lonB CDS" gene complement(2403549..2405207) /gene="lonB" /locus_tag="BSU_28210" /old_locus_tag="BSU28210" /label="lonB gene" downshifts complement(2403568) /Source="Nicolas_upshifts" /id="D1442" /incds=0 /nref=24 /ntot=42 /MaxReadThrough="2.32825" /MaxDrop="4.82102" /score="7.30551887" /energy="-7.1" /TU="NA" /idTUdmin="U2183" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2405251..2405269) /Source="Nicolas_upshift_promotors" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2405262) /Source="Nicolas_upshifts" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2405285..2405290) /Source="Nicolas_upshift_promotors" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2405359..2406621) /gene="clpX" /locus_tag="BSU_28220" /old_locus_tag="BSU28220" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11395451, 11807061, 12354604, 12761164, 14679237, 15948963, 16899079, 17827297, 17981983, 18662407, 19136590, 25433860, 27014237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11395451, 11807061, 12354604, 12761164, 14679237, 15948963, 16899079, 17827297, 17981983, 18662407, 19136590, 25433860, 27014237; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein unfolding ATPase required for presentation of proteins to proteases; Maxwell's demon" /protein_id="NP_390700.2" /db_xref="EnsemblGenomes-Gn:BSU28220" /db_xref="EnsemblGenomes-Tr:CAB14782" /db_xref="GOA:P50866" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004487" /db_xref="InterPro:IPR010603" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11387" /db_xref="UniProtKB/Swiss-Prot:P50866" /translation="MFKFNEEKGQLKCSFCGKTQDQVRKLVAGPGVYICDECIELCTE IVEEELGTEEEVEFKDVPKPQEIREILNEYVIGQDQAKKSLAVAVYNHYKRINSNSKV DDVELSKSNISLIGPTGSGKTLLAQTLARILNVPFAIADATSLTEAGYVGEDVENILL KLIQAADYDVEKAEKGIIYIDEIDKVARKSENPSITRDVSGEGVQQALLKILEGTVAS VPPQGGRKHPHQEFIQIDTTNILFICGGAFDGIEQIIKRRLGQKVIGFGADNKAADLE KEDLLSKVLPEDLLRFGLIPEFIGRLPVIASLEKLDEEALVAILTKPKNALVKQFKKM LELDNVELEFEEEALSEIAKKAIERKTGARGLRSIIEGIMLDVMFELPSRDDIEKCVI TGATVTHGEPPRLLLKDGTEVSQDKTSA*" /label="clpX CDS" gene complement(2405359..2406621) /gene="clpX" /locus_tag="BSU_28220" /old_locus_tag="BSU28220" /label="clpX gene" downshifts complement(2405369) /Source="Nicolas_upshifts" /id="D1443" /incds=0 /nref=256 /ntot=333 /MaxReadThrough="2.8818" /MaxDrop="7.82186" /score="40.299167" /energy="-18.9" /TU="U2185" /idTUdmin="U2184" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" S_feature complement(2406622..2406711) /Source="Nicolas_S_feature" /locus_tag="new_2886044_2886133_c" /HighExp="dia15, dia5, Salt, Diami, C90, H2O2, Paraq, Oxctl, S1, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA, SigA, SigA" /TUlongPSig="1, 0.998, 0.896" /label="S1067" promotor_-10 complement(2406699..2406718) /Source="Nicolas_upshift_promotors" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2406711) /Source="Nicolas_upshifts" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2406713..2406844) /Source="Nicolas_S_feature" /locus_tag="new_2886135_2886266_c" /HighExp="H2O2, dia15, Paraq, Oxctl, G180, G135, HPh, G150, LPh, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.896" /label="S1068" promotor_-35 complement(2406730..2406737) /Source="Nicolas_upshift_promotors" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2406889) /Source="Nicolas_upshifts" /id="D1444" /incds=0 /nref=4 /ntot=16 /MaxReadThrough="8.26501" /MaxDrop="4.34985" /score="-0.284489083" /energy="-10.7" /TU="U2185,U2190" /idTUdmin="U2190" /TUdmin="-153" /isTUend="FALSE" /label="downshifts" CDS complement(2406893..2408167) /gene="tig" /locus_tag="BSU_28230" /old_locus_tag="BSU28230" /EC_number="5.2.1.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9748346, 12224648, 16156784, 17021213" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9748346, 12224648, 16156784, 17021213; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prolyl isomerase (trigger factor)" /protein_id="NP_390701.1" /db_xref="EnsemblGenomes-Gn:BSU28230" /db_xref="EnsemblGenomes-Tr:CAB14783" /db_xref="GOA:P80698" /db_xref="InterPro:IPR001179" /db_xref="InterPro:IPR005215" /db_xref="InterPro:IPR008880" /db_xref="InterPro:IPR008881" /db_xref="InterPro:IPR027304" /db_xref="InterPro:IPR036611" /db_xref="SubtiList:BG19023" /db_xref="UniProtKB/Swiss-Prot:P80698" /translation="MSVKWEKQEGNEGVLTVEVDAETFKTALDDAFKKVVKQVSIPGF RKGKIPRGLFEQRFGVEALYQDALDILLPVEYPKAVEEAGIEPVDRPEIDVEKIEKGE SLIFTAKVTVKPEVKLGEYKGLGIEKDDTTVTDEDVQNELKALQERQAELVVKEEGAV EEGNTVVLDFEGFVDGEAFEGGKAENYSLEVGSGSFIPGFEDQLVGLEAGAEKDVEVT FPEEYHAEDLAGKPAVFKVKIHEIKAKELPELDDEFAKDIDEEVETLAELTEKTKKRL EEAKENEADAKLREELVLKASENAEIDVPQAMVDTELDRMLKEFEQRLQMQGMNLELY TQFSGQDEAALKEQMKEDAEKRVKSNLTLEAIAKAENLEVSDEEVDAELTKMAEAYNM PVENIKQAIGSTDAMKEDLKVRKAIDFLVENR*" /label="tig CDS" gene complement(2406893..2408167) /gene="tig" /locus_tag="BSU_28230" /old_locus_tag="BSU28230" /label="tig gene" S_feature complement(2408168..2408357) /Source="Nicolas_S_feature" /locus_tag="new_2887590_2887779_c" /HighExp="H2O2, HPh, BMM, dia15, T-4.40H, G180, Paraq, Oxctl, LBGexp, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.896" /label="S1069" promotor_-10 complement(2408344..2408363) /Source="Nicolas_upshift_promotors" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2408357) /Source="Nicolas_upshifts" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2408378..2408382) /Source="Nicolas_upshift_promotors" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2408395..2409399) /gene="ysoA" /locus_tag="BSU_28240" /old_locus_tag="BSU28240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390702.2" /db_xref="EnsemblGenomes-Gn:BSU28240" /db_xref="EnsemblGenomes-Tr:CAB14784" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG12338" /db_xref="UniProtKB/Swiss-Prot:P94569" /translation="MTHDKKNAKIIPFPHLKDRLVEKGMSSLKEKKYQEALELFSEAM KYDDTESDLHLGMAICFLELGELEEAESVCEKMLKEGYGHYFTVLQVYMTILIQLKKY EEVKSTIEAVLEENQLPAESAEQFYKLLDFSRKMTDPDREDEAWAEEYEDTIDTEKVL ASPEEQMNLIHSLKDRNVAKYTGLLKTILQDPSAHPIIKTMIVMLLAEHEYSKPVHIS KFGESLTIEPSEIVPPDAAPILHRVLRVLDETLGNENPTLYAAVEELWRRHLYVLYPF QPKLLSADLWAAALHKVGYEMHGIEIESEELHMMYEFTDRELDEACTMLKDIEEISYL *" /label="ysoA CDS" gene complement(2408395..2409399) /gene="ysoA" /locus_tag="BSU_28240" /old_locus_tag="BSU28240" /label="ysoA gene" promotor_-10 complement(2409424..2409443) /Source="Nicolas_upshift_promotors" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-10" upshifts complement(2409442) /Source="Nicolas_upshifts" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="upshifts" promotor_-35 complement(2409455..2409462) /Source="Nicolas_upshift_promotors" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-35" CDS complement(2409518..2410117) /gene="leuD" /locus_tag="BSU_28250" /old_locus_tag="BSU28250" /EC_number="4.2.1.33" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydratase (small subunit)" /protein_id="NP_390703.1" /db_xref="EnsemblGenomes-Gn:BSU28250" /db_xref="EnsemblGenomes-Tr:CAB14785" /db_xref="GOA:P94568" /db_xref="InterPro:IPR000573" /db_xref="InterPro:IPR004431" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR033940" /db_xref="SubtiList:BG11950" /db_xref="UniProtKB/Swiss-Prot:P94568" /translation="MEPLKSHTGKAAVLNRINVDTDQIIPKQFLKRIERTGYGRFAFF DWRYDANGEPNPEFELNQPVYQGASILIAGENFGCGSSREHAPWALDDYGFKIIIAPS FADIFHQNCFKNGMLPIRMPYDNWKQLVGQYENQSLQMTVDLENQLIHDSEGNQISFE VDPHWKEMLINGYDEISLTLLLEDEIKQFESQRSSWLQA*" /label="leuD CDS" gene complement(2409518..2410117) /gene="leuD" /locus_tag="BSU_28250" /old_locus_tag="BSU28250" /label="leuD gene" downshifts complement(2409539) /Source="Nicolas_upshifts" /id="D1445" /incds=0 /nref=5 /ntot=111 /MaxReadThrough="6.76876" /MaxDrop="3.81278" /score="12.2084487" /energy="-9.9" /TU="U2190,U2191" /idTUdmin="U2186" /TUdmin="-1176" /isTUend="FALSE" /label="downshifts" CDS complement(2410130..2411548) /gene="leuC" /locus_tag="BSU_28260" /old_locus_tag="BSU28260" /EC_number="4.2.1.33" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydratase (large subunit)" /protein_id="NP_390704.1" /db_xref="EnsemblGenomes-Gn:BSU28260" /db_xref="EnsemblGenomes-Tr:CAB14786" /db_xref="GOA:P80858" /db_xref="InterPro:IPR001030" /db_xref="InterPro:IPR004430" /db_xref="InterPro:IPR015931" /db_xref="InterPro:IPR015932" /db_xref="InterPro:IPR018136" /db_xref="InterPro:IPR033941" /db_xref="InterPro:IPR036008" /db_xref="SubtiList:BG11949" /db_xref="UniProtKB/Swiss-Prot:P80858" /translation="MMPRTIIEKIWDQHIVKHGEGKPDLLYIDLHLIHEVTSPQAFEG LRQKGRKVRRPQNTFATMDHNIPTVNRFEIKDEVAKRQVTALERNCEEFGVRLADLHS VDQGIVHVVGPELGLTLPGKTIVCGDSHTSTHGAFGALAFGIGTSEVEHVLSTQTLWQ QRPKTLEVRVDGTLQKGVTAKDVILAVIGKYGVKFGTGYVIEYTGEVFRNMTMDERMT VCNMSIEAGARAGLIAPDEVTFEYCKNRKYTPKGEEFDKAVEEWKALRTDPGAVYDKS IVLDGNKISPMVTWGINPGMVLPVDSEVPAPESFSAEDDKKEAIRAYEYMGLTPHQKI EDIKVEHVFIGSCTNSRMTDLRQAADMIKGKKVADSVRAIVVPGSQSVKLQAEKEGLD QIFLEAGFEWRESGCSMCLSMNNDVVPEGERCASTSNRNFEGRQGKGARTHLVSPAMA AMAAIHGHFVDVRKFYQEKTVV*" /label="leuC CDS" gene complement(2410130..2411548) /gene="leuC" /locus_tag="BSU_28260" /old_locus_tag="BSU28260" /label="leuC gene" promotor_-35 2411437..2411441 /Source="Nicolas_upshift_promotors" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2411456..2411460 /Source="Nicolas_upshift_promotors" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2411456 /Source="Nicolas_upshifts" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2411598..2412695) /gene="leuB" /locus_tag="BSU_28270" /old_locus_tag="BSU28270" /EC_number="1.1.1.85" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10095787, 15228537, 15916605, 17389690" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10095787, 15228537, 15916605, 17389690; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydrogenase" /protein_id="NP_390705.2" /db_xref="EnsemblGenomes-Gn:BSU28270" /db_xref="EnsemblGenomes-Tr:CAB14787" /db_xref="GOA:P05645" /db_xref="InterPro:IPR004429" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="SubtiList:BG10675" /db_xref="UniProtKB/Swiss-Prot:P05645" /translation="MKKRIALLPGDGIGPEVLESATDVLKSVAERFNHEFEFEYGLIG GAAIDEHHNPLPEETVAACKNADAILLGAVGGPKWDQNPSELRPEKGLLSIRKQLDLF ANLRPVKVFESLSDASPLKKEYIDNVDFVIVRELTGGLYFGQPSKRYVNTEGEQEAVD TLFYKRTEIERVIREGFKMAAARKGKVTSVDKANVLESSRLWREVAEDVAQEFPDVKL EHMLVDNAAMQLIYAPNQFDVVVTENMFGDILSDEASMLTGSLGMLPSASLSSSGLHL FEPVHGSAPDIAGKGMANPFAAILSAAMLLRTSFGLEEEAKAVEDAVNKVLASGKRTR DLARSEEFSSTQAITEEVKAAIMSENTISNV*" /label="leuB CDS" gene complement(2411598..2412695) /gene="leuB" /locus_tag="BSU_28270" /old_locus_tag="BSU28270" /label="leuB gene" CDS complement(2412716..2414272) /gene="leuA" /locus_tag="BSU_28280" /old_locus_tag="BSU28280" /EC_number="2.3.3.13" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605, 16330546; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-isopropylmalate synthase" /protein_id="NP_390706.1" /db_xref="EnsemblGenomes-Gn:BSU28280" /db_xref="EnsemblGenomes-Tr:CAB14788" /db_xref="GOA:P94565" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR002034" /db_xref="InterPro:IPR005671" /db_xref="InterPro:IPR013709" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036230" /db_xref="SubtiList:BG11948" /db_xref="UniProtKB/Swiss-Prot:P94565" /translation="MRKINFFDTTLRDGEQSPGVNLNTQEKLAIAKQLERLGADIIEA GFPASSRGDFLAVQEIARTIKNCSVTGLARCVKGDIDAAWEALKDGAQPRIHVFIATS DIHLKHKLKMTREQVIERAVGMVKYAKERFPIVQWSAEDACRTELPFLAEIVEKVIDA GASVINLPDTVGYLAPAEYGNIFKYMKENVPNIHKAKLSAHCHDDLGMAVANSLAAIE NGADQIECAVNGIGERAGNAALEEIAVALHTRKDFYQVETGITLNEIKRTSDLVSKLT GMAVPRNKAVVGDNAFAHESGIHQDGFLKEKSTYEIISPELVGVTADALVLGKHSGRH AFKDRLTALGFQFDSEEINKFFTMFKELTEKKKEITDEDLVSLILEEKVTDRKIGYEF LSLQVHYGTSQVPTATLSLKNQENAQLIQEAATGAGSVEAIYNTLERCIDKDVELLDY RIQSNRKGEDAFAQVYVRVLVNGKESAGRGIAQDVLEASAKAYLNAVNRQLVFQSNMS GLKNHTAVGS*" /label="leuA CDS" gene complement(2412716..2414272) /gene="leuA" /locus_tag="BSU_28280" /old_locus_tag="BSU28280" /label="leuA gene" promotor_-35 2413112..2413115 /Source="Nicolas_upshift_promotors" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2413128..2415569 /Source="Nicolas_S_feature" /locus_tag="new_2892550_2894991" /HighExp="Lbstat, C30, T0.30H, M9-stat, T1.30H, H2O2, M0t90, T2.0H, Salt, BC" /AntisenseName="ilvC" /AntisenseCor="-0.51305153097242795" /AntisenseRegPval="-18.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1070" upshifts 2413128 /Source="Nicolas_upshifts" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2413130..2413149 /Source="Nicolas_upshift_promotors" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2414259..2415287) /gene="ilvC" /locus_tag="BSU_28290" /old_locus_tag="BSU28290" /EC_number="1.1.1.86" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605, 25393291, 25849365; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid isomeroreductase (NADP-dependent)" /protein_id="NP_390707.1" /db_xref="EnsemblGenomes-Gn:BSU28290" /db_xref="EnsemblGenomes-Tr:CAB14789" /db_xref="GOA:P37253" /db_xref="InterPro:IPR000506" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013023" /db_xref="InterPro:IPR013116" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR014359" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10672" /db_xref="UniProtKB/Swiss-Prot:P37253" /translation="MVKVYYNGDIKENVLAGKTVAVIGYGSQGHAHALNLKESGVDVI VGVRQGKSFTQAQEDGHKVFSVKEAAAQAEIIMVLLPDEQQQKVYEAEIKDELTAGKS LVFAHGFNVHFHQIVPPADVDVFLVAPKGPGHLVRRTYEQGAGVPALFAIYQDVTGEA RDKALAYAKGIGGARAGVLETTFKEETETDLFGEQAVLCGGLSALVKAGFETLTEAGY QPELAYFECLHELKLIVDLMYEEGLAGMRYSISDTAQWGDFVSGPRVVDAKVKESMKE VLKDIQNGTFAKEWIVENQVNRPRFNAINASENEHQIEVVGRKLREMMPFVKQGKKKE AVVSVAQN*" /label="ilvC CDS" gene complement(2414259..2415287) /gene="ilvC" /locus_tag="BSU_28290" /old_locus_tag="BSU28290" /label="ilvC gene" CDS complement(2415311..2415829) /gene="ilvH" /locus_tag="BSU_28300" /old_locus_tag="BSU28300" /EC_number="2.2.1.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10229948, 14702326, 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid synthase (small subunit)" /protein_id="NP_390708.2" /db_xref="EnsemblGenomes-Gn:BSU28300" /db_xref="EnsemblGenomes-Tr:CAB14790" /db_xref="GOA:P37252" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004789" /db_xref="InterPro:IPR019455" /db_xref="SubtiList:BG10671" /db_xref="UniProtKB/Swiss-Prot:P37252" /translation="MKRIITLTVVNRSGVLNRITGLFTKRHYNIESITVGHTETAGVS RITFVVHVEGENDVEQLTKQLNKQIDVLKVTDITNQSIVQRELALIKVVSAPSTRTEI NGIIEPFRASVVDVSRDSIVVQVTGESNKIEALIELLKPYGIKEIARTGTTAFARGTQ QKASSNKTISIV*" /label="ilvH CDS" gene complement(2415311..2415829) /gene="ilvH" /locus_tag="BSU_28300" /old_locus_tag="BSU28300" /label="ilvH gene" promotor_-35 2415550..2415553 /Source="Nicolas_upshift_promotors" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2415569..2415573 /Source="Nicolas_upshift_promotors" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2415571 /Source="Nicolas_upshifts" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2415826..2417550) /gene="ilvB" /locus_tag="BSU_28310" /old_locus_tag="BSU28310" /EC_number="2.2.1.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10229948, 14702326, 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid synthase (large subunit)" /protein_id="NP_390709.1" /db_xref="EnsemblGenomes-Gn:BSU28310" /db_xref="EnsemblGenomes-Tr:CAB14791" /db_xref="GOA:P37251" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR012846" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10670" /db_xref="UniProtKB/Swiss-Prot:P37251" /translation="MGTNVQVDSASAECTQTMSGALMLIESLKKEKVEMIFGYPGGAV LPIYDKLYNSGLVHILPRHEQGAIHAAEGYARVSGKPGVVIATSGPGATNLVTGLADA MIDSLPLVVFTGQVATSVIGSDAFQEADILGITMPVTKHSYQVRQPEDLPRIIKEAFH IATTGRPGPVLIDIPKDVATIEGEFSYDHEMNLPGYQPTTEPNYLQIRKLVEAVSSAK KPVILAGAGVLHGKASEELKNYAEQQQIPVAHTLLGLGGFPADHPLFLGMAGMHGTYT ANMALHECDLLISIGARFDDRVTGNLKHFARNAKIAHIDIDPAEIGKIMKTQIPVVGD SKIVLQELIKQDGKQSDSSEWKKQLAEWKEEYPLWYVDNEEEGFKPQKLIEYIHQFTK GEAIVATDVGQHQMWSAQFYPFQKADKWVTSGGLGTMGFGLPAAIGAQLAEKDATVVA VVGDGGFQMTLQELDVIRELNLPVKVVILNNACLGMVRQWQEIFYEERYSESKFASQP DFVKLSEAYGIKGIRISSEAEAKEKLEEALTSREPVVIDVRVASEEKVFPMVAPGKGL HEMVGVKP*" /label="ilvB CDS" gene complement(2415826..2417550) /gene="ilvB" /locus_tag="BSU_28310" /old_locus_tag="BSU28310" /label="ilvB gene" S_feature complement(2417551..2417671) /Source="Nicolas_S_feature" /locus_tag="new_2896973_2897093_c" /HighExp="T-5.40H, T-4.40H, S2, MG 120, Glucon, GM-0.2, T-2.40H, GM-0.1, HiOs, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1071" misc_RNA complement(2417672..2417918) /gene="tboILV" /locus_tag="BSU_misc_RNA_45" /product="T-box controlling synthesis of branched chain amino acids" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboILV RNA" gene complement(2417672..2417918) /gene="tboILV" /locus_tag="BSU_misc_RNA_45" /label="tboILV gene" downshifts complement(2417715) /Source="Nicolas_upshifts" /id="D1446" /incds=0 /nref=18 /ntot=78 /MaxReadThrough="7.67475" /MaxDrop="4.2339" /score="5.33237345" /energy="-13.8" /TU="U2190,U2191" /idTUdmin="U2195" /TUdmin=2682 /isTUend="FALSE" /label="downshifts" S_feature complement(2417919..2418045) /Source="Nicolas_S_feature" /locus_tag="new_2897341_2897467_c" /HighExp="LoTm, HiOs, T-3.40H, BC, B60, Pyr, GM 15, T-5.40H, UNK1, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1072" promotor_-10 complement(2418027..2418046) /Source="Nicolas_upshift_promotors" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="promotor_-10" upshifts complement(2418045) /Source="Nicolas_upshifts" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="upshifts" S_feature complement(2418047..2418177) /Source="Nicolas_S_feature" /locus_tag="new_2897469_2897599_c" /HighExp="Cold, S8, S0, S7, Mal, S6, G135, M9-stat, C30, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1073" promotor_-35 complement(2418061..2418068) /Source="Nicolas_upshift_promotors" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="promotor_-35" promotor_-10 complement(2418172..2418191) /Source="Nicolas_upshift_promotors" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-10" upshifts complement(2418181) /Source="Nicolas_upshifts" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="upshifts" promotor_-35 complement(2418205..2418208) /Source="Nicolas_upshift_promotors" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-35" promotor_-35 2418303..2418312 /Source="Nicolas_upshift_promotors" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2418326..2418345 /Source="Nicolas_upshift_promotors" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2418328 /Source="Nicolas_upshifts" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="upshifts" CDS 2418366..2418701 /gene="cotQ" /locus_tag="BSU_28320" /old_locus_tag="BSU28320" /experiment="publication(s) with functional evidences, PMID:19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_390710.1" /db_xref="EnsemblGenomes-Gn:BSU28320" /db_xref="EnsemblGenomes-Tr:CAB14792" /db_xref="SubtiList:BG12335" /db_xref="UniProtKB/Swiss-Prot:P94563" /translation="MNKSFADMQGFPAGFPSFPNFPQQYYPAVPPFYQQSQQPFGGYG YGQPFSQAYSPLTTPSGMYSSFPYASGFYGQQFSGAGFSGHGGSLSAPAIHAGGFSGA PGVHGGFRY*" /label="cotQ CDS" gene 2418366..2418701 /gene="cotQ" /locus_tag="BSU_28320" /old_locus_tag="BSU28320" /label="cotQ gene" downshifts 2418695 /Source="Nicolas_upshifts" /id="D1447" /incds=0 /nref=14 /ntot=36 /MaxReadThrough="3.79194" /MaxDrop="6.48183" /score="11.836855" /energy="-13" /TU="U2192" /idTUdmin="U2193" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" promotor_-35 2418782..2418789 /Source="Nicolas_upshift_promotors" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2418803..2418822 /Source="Nicolas_upshift_promotors" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2418805..2418869 /Source="Nicolas_S_feature" /locus_tag="new_2898227_2898291" /HighExp="S5, S6, S8, S7, B36, S4, S3, B60, BT, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.954, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1074" upshifts 2418805 /Source="Nicolas_upshifts" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="upshifts" CDS 2418870..2419325 /gene="ysnE" /locus_tag="BSU_28330" /old_locus_tag="BSU28330" /EC_number="2.3.1.-" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17555270, 26337367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative indole acetic acid N-acetyltransferase" /protein_id="NP_390711.1" /db_xref="EnsemblGenomes-Gn:BSU28330" /db_xref="EnsemblGenomes-Tr:CAB14793" /db_xref="GOA:P94562" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1YX0" /db_xref="SubtiList:BG12336" /db_xref="UniProtKB/Swiss-Prot:P94562" /translation="MHIKIDDLTGRQVVSLVNEHLHSMTLMSPPESIHALGLEKLRGP EITFWSAWEGDELAGCGALKELDTRHGEIKSMRTSASHLRKGVAKQVLQHIIEEAEKR GYERLSLETGSMASFEPARKLYESFGFQYCEPFADYGEDPNSVFMTKKL*" /label="ysnE CDS" gene 2418870..2419325 /gene="ysnE" /locus_tag="BSU_28330" /old_locus_tag="BSU28330" /label="ysnE gene" promotor_-35 2419433..2419439 /Source="Nicolas_upshift_promotors" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2419453..2419471 /Source="Nicolas_upshift_promotors" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2419460 /Source="Nicolas_upshifts" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="upshifts" CDS 2419509..2420330 /gene="ysnF" /locus_tag="BSU_28340" /old_locus_tag="BSU28340" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534, 27464829; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative stress response protein" /protein_id="NP_390712.3" /db_xref="EnsemblGenomes-Gn:BSU28340" /db_xref="EnsemblGenomes-Tr:CAB14794" /db_xref="InterPro:IPR019060" /db_xref="InterPro:IPR025889" /db_xref="SubtiList:BG12337" /db_xref="UniProtKB/Swiss-Prot:P94560" /translation="MKSIVGVYETPQETIAAIEGLLTKGYDSDDISVVTSRRDTDYLE SRTGTEVNQAIDAHQDESESFFDKLKDYFTMDDTATHSKALSDLDIKTDEIDKYQEDL DDGKLLVAVDTDADVIAPIDNGNALSGGFSSTNELDYTTKEEKTMPLREEQLKVDKED VQTGEVEIGKEVKTEKRDMDIPVRHDEIYVERRPVDENKTDAAPVNDSEEIRVPIVEE KLEVTKKPVVTDEVVVGKRTVEENEHISETVKKEEPRLNKEGKVDGLDDDPLNNK*" /label="ysnF CDS" gene 2419509..2420330 /gene="ysnF" /locus_tag="BSU_28340" /old_locus_tag="BSU28340" /label="ysnF gene" downshifts 2420323 /Source="Nicolas_upshifts" /id="D1448" /incds=0 /nref=8 /ntot=77 /MaxReadThrough="2.49244" /MaxDrop="8.12771" /score="22.7277041" /energy="-13.3" /TU="NA" /idTUdmin="U2194" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" downshifts 2420387 /Source="Nicolas_upshifts" /id="D1449" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="1.26489" /MaxDrop="4.30778" /score="22.7277041" /energy="-13.3" /TU="NA" /idTUdmin="U2194" /TUdmin=43 /isTUend="FALSE" /label="downshifts" tRNA complement(2420394..2420467) /gene="trnSL-Arg2" /locus_tag="BSU_tRNA_84" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Arg (UCU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Arg2 tRNA" gene complement(2420394..2420467) /gene="trnSL-Arg2" /locus_tag="BSU_tRNA_84" /label="trnSL-Arg2 gene" downshifts complement(2420428) /Source="Nicolas_upshifts" /id="D1450" /incds=0 /nref=34 /ntot=243 /MaxReadThrough="1.54905" /MaxDrop="4.72186" /score="24.0242272" /energy="-13.3" /TU="U2195,U2196" /idTUdmin="U2195" /TUdmin="-31" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2420504..2420523) /Source="Nicolas_upshift_promotors" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2420507) /Source="Nicolas_upshifts" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2420537..2420544) /Source="Nicolas_upshift_promotors" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2420598..2421107) /gene="ysnB" /locus_tag="BSU_28350" /old_locus_tag="BSU28350" /EC_number="3.1.4.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoesterase" /protein_id="NP_390713.2" /db_xref="EnsemblGenomes-Gn:BSU28350" /db_xref="EnsemblGenomes-Tr:CAB14795" /db_xref="GOA:P94559" /db_xref="InterPro:IPR000979" /db_xref="InterPro:IPR020935" /db_xref="InterPro:IPR024654" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12334" /db_xref="UniProtKB/Swiss-Prot:P94559" /translation="MNVLIISDSHGLEEELQTIAKRHEAEVDLMIHCGDSELETRHPA LEPYAVVKGNCDFAGDFKDELLLTAGSRKILVTHGHLHGIKQTLLNVYYRAEELGADV ICFGHSHIAGSEVLRGKLMINPGSIRLPRVRRTESYAILTLENDAATVRFYDQAGNEI EDLQNRVTL*" /label="ysnB CDS" gene complement(2420598..2421107) /gene="ysnB" /locus_tag="BSU_28350" /old_locus_tag="BSU28350" /label="ysnB gene" downshifts complement(2420615) /Source="Nicolas_upshifts" /id="D1451" /incds=0 /nref=87 /ntot=225 /MaxReadThrough="4.15666" /MaxDrop="5.59323" /score="24.0242272" /energy="-13.3" /TU="U2196,U2197" /idTUdmin="U2197" /TUdmin="-130" /isTUend="FALSE" /label="downshifts" CDS complement(2421123..2421719) /gene="rdgB" /locus_tag="BSU_28360" /old_locus_tag="BSU28360" /EC_number="3.6.1.66" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16322510, 17090528, 17976651, 18689515, 19943897; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyinosine/deoxyxanthosine triphosphate pyrophosphatase, promiscuous (subunit A)" /protein_id="NP_390714.1" /db_xref="EnsemblGenomes-Gn:BSU28360" /db_xref="EnsemblGenomes-Tr:CAB14796" /db_xref="GOA:P94558" /db_xref="InterPro:IPR002637" /db_xref="InterPro:IPR020922" /db_xref="InterPro:IPR029001" /db_xref="SubtiList:BG12333" /db_xref="UniProtKB/Swiss-Prot:P94558" /translation="MIIMKEAIIATHNPGKVKEFKEILEPRGYDVKSLAEIGFTEEIE ETGHTFEENAIMKAEAVAKAVNKMVIADDSGLSIDNLGGRPGVYSARYAGEQKDDQAN IEKVLSELKGIEKEQRTARFRCALAVSIPGEETKTVEGHVEGYIAEEPRGEYGFGYDP IFIVKDKDKTMAELTSDEKNKISHRADALKKLSKLLEA*" /label="rdgB CDS" gene complement(2421123..2421719) /gene="rdgB" /locus_tag="BSU_28360" /old_locus_tag="BSU28360" /label="rdgB gene" CDS complement(2421732..2422469) /gene="rph" /locus_tag="BSU_28370" /old_locus_tag="BSU28370" /EC_number="2.7.7.56" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1624460, 19153445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1624460, 19153445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease PH" /protein_id="NP_390715.1" /db_xref="EnsemblGenomes-Gn:BSU28370" /db_xref="EnsemblGenomes-Tr:CAB14797" /db_xref="GOA:P28619" /db_xref="InterPro:IPR001247" /db_xref="InterPro:IPR002381" /db_xref="InterPro:IPR015847" /db_xref="InterPro:IPR018336" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027408" /db_xref="InterPro:IPR036345" /db_xref="PDB:1OYP" /db_xref="PDB:1OYR" /db_xref="PDB:1OYS" /db_xref="SubtiList:BG10357" /db_xref="UniProtKB/Swiss-Prot:P28619" /translation="MRHDGRQHDELRPITFDLDFISHPEGSVLITAGNTKVICNASVE DRVPPFLRGGGKGWITAEYSMLPRATNQRTIRESSKGKISGRTMEIQRLIGRALRAVV DLEKLGERTIWIDCDVIQADGGTRTASITGAFLAMAIAIGKLIKAGTIKTNPITDFLA AISVGIDKEQGILLDLNYEEDSSAEVDMNVIMTGSGRFVELQGTGEEATFSREDLNGL LGLAEKGIQELIDKQKEVLGDSLPELK*" /label="rph CDS" gene complement(2421732..2422469) /gene="rph" /locus_tag="BSU_28370" /old_locus_tag="BSU28370" /label="rph gene" promotor_-10 complement(2422551..2422570) /Source="Nicolas_upshift_promotors" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2422567) /Source="Nicolas_upshifts" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2422580..2423680) /gene="gerM" /locus_tag="BSU_28380" /old_locus_tag="BSU28380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14662349, 27381174" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14662349, 27381174; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="germination (cortex hydrolysis) and sporulation (stage II, multiple polar septa) lytic enzyme" /protein_id="NP_390716.1" /db_xref="EnsemblGenomes-Gn:BSU28380" /db_xref="EnsemblGenomes-Tr:CAB14798" /db_xref="GOA:P39072" /db_xref="InterPro:IPR019606" /db_xref="SubtiList:BG10356" /db_xref="UniProtKB/Swiss-Prot:P39072" /translation="MLKKGPAVIGATCLTSALLLSGCGLFQSDKAAEEIDPPQDVTFV NDEAGANSNTTAAKKTESEKSDTAKADQASSTVMRELYLIDKNGYVVAQTLPLPKSES TAKQALEYLVQGGPVSEILPNGFRAVLPADTTVNVDIKKDGTAIADFSNEFKNYKKED EQKIVQSVTWTLTQFSSIDKVKLRINGHELKEMPVGGTPISDDLSRKDGINLETAGVN DLTATHPLTVYYLAENEDSEYYVPVTKRIDNSEKDDITAAINELAKGPSKVSGLLTDF SEDVKLVSKPKIKDGRVTLDFNQSIFGSADEKTKMISSEVLNSIVLTLTEQPDVKSVS VKVNGKSELVNEKGEKLTEPVSRPSQVNTGSF*" /label="gerM CDS" gene complement(2422580..2423680) /gene="gerM" /locus_tag="BSU_28380" /old_locus_tag="BSU28380" /label="gerM gene" promotor_-35 complement(2422585..2422590) /Source="Nicolas_upshift_promotors" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2422597) /Source="Nicolas_upshifts" /id="D1452" /incds=0 /nref=2 /ntot=16 /MaxReadThrough="5.80816" /MaxDrop="4.3535" /score="41.5916163" /energy="-13" /TU="U2197" /idTUdmin="U2198" /TUdmin=1209 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2423703..2423721) /Source="Nicolas_upshift_promotors" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2423719) /Source="Nicolas_upshifts" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2423736..2423741) /Source="Nicolas_upshift_promotors" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2423795..2424613) /gene="rcmE" /locus_tag="BSU_28390" /old_locus_tag="BSU28390" /EC_number="5.1.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15347750, 17610893, 17720142, 19309142; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate racemase" /protein_id="NP_390717.2" /db_xref="EnsemblGenomes-Gn:BSU28390" /db_xref="EnsemblGenomes-Tr:CAB14799" /db_xref="GOA:P94556" /db_xref="InterPro:IPR001920" /db_xref="InterPro:IPR004391" /db_xref="InterPro:IPR015942" /db_xref="InterPro:IPR018187" /db_xref="InterPro:IPR033134" /db_xref="PDB:1ZUW" /db_xref="SubtiList:BG11964" /db_xref="UniProtKB/Swiss-Prot:P94556" /translation="MLEQPIGVIDSGVGGLTVAKEIMRQLPKENIIYVGDTKRCPYGP RPEEEVLQYTWELTNYLLENHHIKMLVIACNTATAIALDDIQRSVGIPVVGVIQPGAR AAIKVTDNQHIGVIGTENTIKSNAYEEALLALNPDLKVENLACPLLVPFVESGKFLDK TADEIVKTSLYPLKDTSIDSLILGCTHYPILKEAIQRYMGEHVNIISSGDETAREVST ILSYKGLLNQSPIAPDHQFLTTGARDQFAKIADDWFGHEVGHVECISLQEPIKR*" /label="rcmE CDS" gene complement(2423795..2424613) /gene="rcmE" /locus_tag="BSU_28390" /old_locus_tag="BSU28390" /label="rcmE gene" downshifts complement(2423807) /Source="Nicolas_upshifts" /id="D1453" /incds=0 /nref=230 /ntot=265 /MaxReadThrough="0.9265" /MaxDrop="6.72492" /score="41.5916163" /energy="-13" /TU="NA" /idTUdmin="U2198" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2424621..2425061) /gene="ysmB" /locus_tag="BSU_28400" /old_locus_tag="BSU28400" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26577401; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (mother cell's gene expression during sporulation)" /protein_id="NP_390718.1" /db_xref="EnsemblGenomes-Gn:BSU28400" /db_xref="EnsemblGenomes-Tr:CAB14800" /db_xref="GOA:P97247" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12332" /db_xref="UniProtKB/Swiss-Prot:P97247" /translation="MTSKPLEHVADIEKSLRHIAAIIKQKGREILNQYAITPPQFVGL QWLYELGDMTIGELSGKMYLACSTTTDLIDRMQKNELVERVKDPADRRVVRIHLLPEG ERIIQEVITKRQEYLRDMFESFTDEEIAIFEKSLMKLQHEMKRK*" /label="ysmB CDS" gene complement(2424621..2425061) /gene="ysmB" /locus_tag="BSU_28400" /old_locus_tag="BSU28400" /label="ysmB gene" promotor_-10 complement(2425104..2425123) /Source="Nicolas_upshift_promotors" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2425113) /Source="Nicolas_upshifts" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2425115..2425257) /Source="Nicolas_S_feature" /locus_tag="new_2904537_2904679_c" /HighExp="BT, B36, S6, S8, S7, B60, Pyr, G/S, Lbtran, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.121047" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1075" promotor_-35 complement(2425139..2425143) /Source="Nicolas_upshift_promotors" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2425302) /Source="Nicolas_upshifts" /id="D1454" /incds=0 /nref=2 /ntot=16 /MaxReadThrough="6.16749" /MaxDrop="4.6532" /score="20.9204638" /energy="-10.8" /TU="U2200,U2202" /idTUdmin="U2202" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" CDS complement(2425305..2425529) /gene="gerE" /locus_tag="BSU_28410" /old_locus_tag="BSU28410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11243786, 11418558, 11741866, 14702409, 17172339, 20435725, 21670523, 26790838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11243786, 11418558, 11741866, 14702409, 17172339, 20435725, 21670523, 26790838; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="transcriptional regulator required for the expression of late spore coat genes" /protein_id="NP_390719.2" /db_xref="EnsemblGenomes-Gn:BSU28410" /db_xref="EnsemblGenomes-Tr:CAB14801" /db_xref="GOA:P11470" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1FSE" /db_xref="SubtiList:BG10355" /db_xref="UniProtKB/Swiss-Prot:P11470" /translation="MKEKEFQSKPLLTKREREVFELLVQDKTTKEIASELFISEKTVR NHISNAMQKLGVKGRSQAVVELLRMGELEL*" /label="gerE CDS" gene complement(2425305..2425529) /gene="gerE" /locus_tag="BSU_28410" /old_locus_tag="BSU28410" /label="gerE gene" upshifts 2425578 /Source="Nicolas_upshifts" /id="U2199" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.838161838161838" /xcortree=697 /SigmaFactorBS="tttctccttcaagtattgtaaccctccttgctaaggtgagag cgaatcagaaacgaatgggtTTTGATATAGTCGAGATATcatatgtaagaagggcgca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2425580..2425598 /Source="Nicolas_upshift_promotors" /id="U2199" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.838161838161838" /xcortree=697 /SigmaFactorBS="tttctccttcaagtattgtaaccctccttgctaaggtgagag cgaatcagaaacgaatgggtTTTGATATAGTCGAGATATcatatgtaagaagggcgca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2425587..2425606) /Source="Nicolas_upshift_promotors" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2425607) /Source="Nicolas_upshifts" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2425620..2425629) /Source="Nicolas_upshift_promotors" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2425645..2426088) /gene="ysmA" /locus_tag="BSU_28420" /old_locus_tag="BSU28420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390720.1" /db_xref="EnsemblGenomes-Gn:BSU28420" /db_xref="EnsemblGenomes-Tr:CAB14802" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG10354" /db_xref="UniProtKB/Swiss-Prot:P11469" /translation="MKLPAYIDMPFQEWKTSFSFFNKVSVRFSETDMFGHMNNVTPFI YFEEVRISYFKKLNMMSENKQTMTVVASQQCDYLRQVMPYEELRIYVKTSAVGSSSLT LHYLGENLEGEPCFTGAVVMVQVSKESGKAVSWTDEEKETLLHTR*" /label="ysmA CDS" gene complement(2425645..2426088) /gene="ysmA" /locus_tag="BSU_28420" /old_locus_tag="BSU28420" /label="ysmA gene" CDS complement(2426149..2426910) /gene="sdhB" /locus_tag="BSU_28430" /old_locus_tag="BSU28430" /EC_number="1.3.5.1" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11803018, 1707123, 22720735, 22389480, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 1707123, 22720735, 22389480, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (iron-sulfur protein)" /protein_id="NP_390721.1" /db_xref="EnsemblGenomes-Gn:BSU28430" /db_xref="EnsemblGenomes-Tr:CAB14803" /db_xref="GOA:P08066" /db_xref="InterPro:IPR004489" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR025192" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG10353" /db_xref="UniProtKB/Swiss-Prot:P08066" /translation="MSEQKTIRFIITRQDTADSTPYDEEFEIPYRPNLNVISALMEIR RNPVNVKGEKTTPVTWDMNCLEEVCGACSMVINGKPRQSCTALIDQLEQPIRLKPMKT FPVVRDLQVDRSRMFDSLKKVKAWIPIDGTYDLGPGPRMPEKRRQWAYELSKCMTCGV CLEACPNVNSKSKFMGPAPMSQVRLFNAHPTGAMNKSERLEALMDEGGLADCGNSQNC VQSCPKGIPLTTSIAALNRDTNLQAFRNFFGSDRV*" /label="sdhB CDS" gene complement(2426149..2426910) /gene="sdhB" /locus_tag="BSU_28430" /old_locus_tag="BSU28430" /label="sdhB gene" downshifts complement(2426157) /Source="Nicolas_upshifts" /id="D1455" /incds=0 /nref=61 /ntot=257 /MaxReadThrough="5.46426" /MaxDrop="4.6864" /score="20.9204638" /energy="-10.8" /TU="U2202" /idTUdmin="U2205" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2426913..2428673) /gene="sdhA" /locus_tag="BSU_28440" /old_locus_tag="BSU28440" /EC_number="1.3.5.1" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11803018, 1707123, 18535631, 22389480, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 1707123, 18535631, 22389480, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (flavoprotein subunit)" /protein_id="NP_390722.2" /db_xref="EnsemblGenomes-Gn:BSU28440" /db_xref="EnsemblGenomes-Tr:CAB14804" /db_xref="GOA:P08065" /db_xref="InterPro:IPR003952" /db_xref="InterPro:IPR003953" /db_xref="InterPro:IPR011280" /db_xref="InterPro:IPR015939" /db_xref="InterPro:IPR027477" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR037099" /db_xref="SubtiList:BG10352" /db_xref="UniProtKB/Swiss-Prot:P08065" /translation="MSQSSIIVVGGGLAGLMATIKAAESGMAVKLFSIVPVKRSHSVC AQGGINGAVNTKGEGDSPWEHFDDTVYGGDFLANQPPVKAMCEAAPSIIHLLDRMGVM FNRTPEGLLDFRRFGGTQHHRTAYAGATTGQQLLYALDEQVRRYEVAGLVTKYEGWEF LGAVLDDDRTCRGIVAQNLTNMQIESFRSDAVIMATGGPGIIFGKSTNSMINTGSAAS IVYQQGAYYANGEFIQIHPTAIPGDDKLRLMSESARGEGGRVWTYKDGKPWYFLEEKY PAYGNLVPRDIATREIFDVCVNQKLGINGENMVYLDLSHKDPKELDIKLGGIIEIYEK FMGDDPRKLPMKIFPAVHYSMGGLWVDYDQMTNIPGLFAAGECDYSMHGGNRLGANSL LSAIYGGMVAGPNAVKYVNGLESSAEDMSSSLFDAHVKKEEEKWADIMSMDGTENAYV LHKELGEWMTANVTVVRHNDKLLKTDDKIQELMERFKKININDTTKWSNQGAMFTRQF SNMLQLARVITLGAYNRNESRGAHYKPDYPERNDDEWLKTTMAKHVSPYEAPEFEYQD VDVSLITPRKRDYSKKKVAK*" /label="sdhA CDS" gene complement(2426913..2428673) /gene="sdhA" /locus_tag="BSU_28440" /old_locus_tag="BSU28440" /label="sdhA gene" CDS complement(2428707..2429315) /gene="sdhC" /locus_tag="BSU_28450" /old_locus_tag="BSU28450" /EC_number="1.3.5.1" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:11803018, 15849754, 16850406, 1707123, 18535631, 22389480, 22389480" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 15849754, 16850406, 1707123, 18535631, 22389480, 22389480; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (cytochrome b558 subunit)" /protein_id="NP_390723.1" /db_xref="EnsemblGenomes-Gn:BSU28450" /db_xref="EnsemblGenomes-Tr:CAB14805" /db_xref="GOA:P08064" /db_xref="InterPro:IPR000701" /db_xref="InterPro:IPR011138" /db_xref="InterPro:IPR016002" /db_xref="InterPro:IPR034804" /db_xref="SubtiList:BG10351" /db_xref="UniProtKB/Swiss-Prot:P08064" /translation="MSGNREFYFRRLHSLLGVIPVGIFLIQHLVVNQFAARGAEAFNS AAHFMDSLPFRYALEIFIIFLPLIYHAVYGVYIAFTAKNNAGQYSYMRNWLFVLQRVT GIITLIFVSWHVWETRIAAQMGAEVNFDMMANILSSPAMLGFYIVGVLSTIFHFSNGL WSFAVTWGITVTPRSQRISTYVTLIIFVALSYVGLKAIFAFV*" /label="sdhC CDS" gene complement(2428707..2429315) /gene="sdhC" /locus_tag="BSU_28450" /old_locus_tag="BSU28450" /label="sdhC gene" promotor_-35 2429085..2429092 /Source="Nicolas_upshift_promotors" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2429105..2429124 /Source="Nicolas_upshift_promotors" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2429107 /Source="Nicolas_upshifts" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2429316..2429411) /Source="Nicolas_S_feature" /locus_tag="new_2908738_2908833_c" /HighExp="Lbtran, dia5, Mt0, T0.30H, T1.0H, M0t90, M40t90, T0.0H, Glucon, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.78844099999999995" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1076" promotor_-10 complement(2429401..2429420) /Source="Nicolas_upshift_promotors" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="promotor_-10" upshifts complement(2429411) /Source="Nicolas_upshifts" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="upshifts" S_feature complement(2429413..2430034) /Source="Nicolas_S_feature" /locus_tag="new_2908835_2909456_c" /HighExp="MG 120, B36, UNK1, Fru, MG 150, BMM, Gly, Glucon, Glu, GM-0.1" /AntisenseName="yslB" /AntisenseCor="-0.44143968421748903" /AntisenseRegPval="-13.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1077" promotor_-35 complement(2429435..2429442) /Source="Nicolas_upshift_promotors" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="promotor_-35" promotor_-35 2429550..2429554 /Source="Nicolas_upshift_promotors" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2429564..2429664 /Source="Nicolas_upshift_promotors" /id="U2204" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.024975024975025" /xcortree=1731 /SigmaFactorBS="ccctgtttgagctataatatacgcaggagagaggggagacag atatgaagtctaaatttgaagcatctattgacaacctaaaagaaattgaaatgaacgc t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 2429571..2429590 /Source="Nicolas_upshift_promotors" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2429580 /Source="Nicolas_upshifts" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="upshifts" CDS 2429608..2430054 /gene="yslB" /locus_tag="BSU_28460" /old_locus_tag="BSU28460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390724.1" /db_xref="EnsemblGenomes-Gn:BSU28460" /db_xref="EnsemblGenomes-Tr:CAB14806" /db_xref="InterPro:IPR019642" /db_xref="InterPro:IPR024096" /db_xref="PDB:3NJC" /db_xref="SubtiList:BG11236" /db_xref="UniProtKB/Swiss-Prot:P42955" /translation="MKSKFEASIDNLKEIEMNAYAYELIREIVLPDMLGQDYSSMMYW AGKHLARKFPLESWEEFPAFFEEAGWGTLTNVSAKKQELEFELEGPIISNRLKHQKEP CFQLEAGFIAEQIQLMNDQIAESYEQVKKRADKVVLTVKWDMKDPV*" /label="yslB CDS" gene 2429608..2430054 /gene="yslB" /locus_tag="BSU_28460" /old_locus_tag="BSU28460" /label="yslB gene" upshifts 2429624 /Source="Nicolas_upshifts" /id="U2204" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.024975024975025" /xcortree=1731 /SigmaFactorBS="ccctgtttgagctataatatacgcaggagagaggggagacag atatgaagtctaaatttgaagcatctattgacaacctaaaagaaattgaaatgaacgc t" /listShort="yslB" /GFF_Attribute="listLong" /label="upshifts" downshifts 2430042 /Source="Nicolas_upshifts" /id="D1456" /incds=0 /nref=217 /ntot=255 /MaxReadThrough="2.21897" /MaxDrop="6.5759" /score="4.74486914" /energy="-10.8" /TU="NA" /idTUdmin="U2203" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2430080) /Source="Nicolas_upshifts" /id="D1457" /incds=0 /nref=8 /ntot=160 /MaxReadThrough="5.89867" /MaxDrop="4.19639" /score="2.38159916" /energy="-10.8" /TU="U2205" /idTUdmin="U2206" /TUdmin=1270 /isTUend="FALSE" /label="downshifts" CDS complement(2430098..2431324) /gene="lysCA" /locus_tag="BSU_28470" /old_locus_tag="BSU28470" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2981221, 2981222, 14597663, 1980002, 8757727, 9851048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2981221, 2981222, 14597663, 1980002, 8757727, 9851048; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase II alpha subunit (aa 1->408)" /protein_id="NP_390725.1" /db_xref="EnsemblGenomes-Gn:BSU28470" /db_xref="EnsemblGenomes-Tr:CAB14807" /db_xref="GOA:P08495" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001341" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005260" /db_xref="InterPro:IPR018042" /db_xref="InterPro:IPR027795" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10350" /db_xref="UniProtKB/Swiss-Prot:P08495" /translation="MGLIVQKFGGTSVGSVEKIQNAANRAIAEKQKGHQVVVVVSAMG KSTDELVSLAKAISDQPSKREMDMLLATGEQVTISLLSMALQEKGYDAVSYTGWQAGI RTEAIHGNARITDIDTSVLADQLEKGKIVIVAGFQGMTEDCEITTLGRGGSDTTAVAL AAALKADKCDIYTDVPGVFTTDPRYVKSARKLEGISYDEMLELANLGAGVLHPRAVEF AKNYQVPLEVRSSTETEAGTLIEEESSMEQNLIVRGIAFEDQITRVTIYGLTSGLTTL STIFTTLAKRNINVDIIIQTQAEDKTGISFSVKTEDADQTVAVLEEYKDALEFEKIET ESKLAKVSIVGSGMVSNPGVAAEMFAVLAQKNILIKMVSTSEIKVSTVVSENDMVKAV ESLHDAFELSKHPSAV*" /label="lysCA CDS" CDS complement(2430098..2430589) /gene="lysCB" /locus_tag="BSU_28475" /old_locus_tag="BSU28475" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1980002, 2981221, 2981222, 8757727, 9851048, 14597663" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1980002, 2981221, 2981222, 8757727, 9851048, 14597663; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase II beta subunit (aa 246->408)" /protein_id="YP_009513994.1" /translation="MEQNLIVRGIAFEDQITRVTIYGLTSGLTTLSTIFTTLAKRNIN VDIIIQTQAEDKTGISFSVKTEDADQTVAVLEEYKDALEFEKIETESKLAKVSIVGSG MVSNPGVAAEMFAVLAQKNILIKMVSTSEIKVSTVVSENDMVKAVESLHDAFELSKHP SAV*" /label="lysCB CDS" gene complement(2430098..2431324) /gene="lysCA" /locus_tag="BSU_28470" /old_locus_tag="BSU28470" /label="lysCA gene" gene complement(2430098..2430589) /gene="lysCB" /locus_tag="BSU_28475" /old_locus_tag="BSU28475" /label="lysCB gene" downshifts complement(2431438) /Source="Nicolas_upshifts" /id="D1458" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="7.23315" /MaxDrop="4.15833" /score="31.7469619" /energy="-13.5" /TU="U2205,U2206" /idTUdmin="U2207" /TUdmin=44 /isTUend="FALSE" /label="downshifts" misc_RNA complement(2431450..2431629) /gene="kswC" /locus_tag="BSU_misc_RNA_46" /product="lysine riboswitch" /experiment="publication(s) with functional evidences, PMID:14523230, 14597663, 14627808, 21169337, 22416067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523230, 14597663, 14627808, 21169337, 22416067; Product type n: RNA" /label="kswC RNA" gene complement(2431450..2431629) /gene="kswC" /locus_tag="BSU_misc_RNA_46" /label="kswC gene" downshifts complement(2431482) /Source="Nicolas_upshifts" /id="D1459" /incds=0 /nref=22 /ntot=132 /MaxReadThrough="7.09997" /MaxDrop="4.61976" /score="31.7469619" /energy="-13.5" /TU="U2205,U2206" /idTUdmin="U2207" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2431654..2431673) /Source="Nicolas_upshift_promotors" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="promotor_-10" upshifts complement(2431661) /Source="Nicolas_upshifts" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="upshifts" promotor_-35 complement(2431686..2431693) /Source="Nicolas_upshift_promotors" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="promotor_-35" CDS complement(2431694..2433466) /gene="uvrC" /locus_tag="BSU_28490" /old_locus_tag="BSU28490" /EC_number="4.1.99.3" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8655545, 16267290, 16426634, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8655545, 16267290, 16426634, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit C)" /protein_id="NP_390727.2" /db_xref="EnsemblGenomes-Gn:BSU28490" /db_xref="EnsemblGenomes-Tr:CAB14809" /db_xref="GOA:P14951" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR001162" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR004791" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR035901" /db_xref="InterPro:IPR036876" /db_xref="SubtiList:BG10349" /db_xref="UniProtKB/Swiss-Prot:P14951" /translation="MNKQLKEKLALLPDQPGCYLMKDRQQTVIYVGKAKVLKNRVRSY FTGSHDAKTQRLVTEIEDFEYIVTSSNLEALILEMNLIKKHDPKYNVMLKDDKTYPFI KLTHERHPRLIVTRNVKKDKGRYFGPYPNVQAARETKKLLDRLYPLRKCSKLPDRVCL YYHLGQCLAPCVKDISEETNRELVESITRFLRGGYNEVKKELEEKMHEAAENLEFERA KELRDQIAHIESTMEKQKMTMNDLVDRDVFAYAYDKGWMCVQVFFIRQGKLIERDVSM FPLYQEADEEFLTFIGQFYSKNNHFLPKEILVPDSIDQSMIEQLLETNVHQPKKGPKK ELLMLAHKNAKIALKEKFSLIERDEERSIGAVQKLGEALNIYTPHRIEAFDNSNIQGT NPVSAMIVFIDGKPYKKEYRKYKIKTVTGPDDYGSMREVVRRRYTRVLRENLPLPDLI IIDGGKGQINAARDVIENELGLDIPIAGLAKDEKHRTSNLLIGDPLEVAYLERNSQEF YLLQRIQDEVHRFAISFHRQIRGKSAFQSVLDDIPGIGEKRKKMLLKHFGSVKKMKEA SLEDIKKAGVPAAAAQLLYDKLQK*" /label="uvrC CDS" gene complement(2431694..2433466) /gene="uvrC" /locus_tag="BSU_28490" /old_locus_tag="BSU28490" /label="uvrC gene" promotor_-10 complement(2433493..2433512) /Source="Nicolas_upshift_promotors" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="promotor_-10" upshifts complement(2433507) /Source="Nicolas_upshifts" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="upshifts" promotor_-35 complement(2433526..2433533) /Source="Nicolas_upshift_promotors" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="promotor_-35" downshifts complement(2433596) /Source="Nicolas_upshifts" /id="D1460" /incds=0 /nref=237 /ntot=268 /MaxReadThrough="4.77689" /MaxDrop="6.41061" /score="23.4086154" /energy="-10.5" /TU="U2207,U2208" /idTUdmin="U2209" /TUdmin=373 /isTUend="FALSE" /label="downshifts" CDS complement(2433602..2433916) /gene="trxA" /locus_tag="BSU_28500" /old_locus_tag="BSU28500" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9537387, 12682299, 1459769, 15937154, 17303556, 18455736, 18601268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9537387, 12682299, 1459769, 15937154, 17303556, 18455736, 18601268; Product type c: carrier" /codon_start=1 /transl_table=11 /product="thioredoxin" /protein_id="NP_390728.1" /db_xref="EnsemblGenomes-Gn:BSU28500" /db_xref="EnsemblGenomes-Tr:CAB14810" /db_xref="GOA:P14949" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR036249" /db_xref="PDB:2GZY" /db_xref="PDB:2GZZ" /db_xref="PDB:2IPA" /db_xref="PDB:2VOC" /db_xref="SubtiList:BG10348" /db_xref="UniProtKB/Swiss-Prot:P14949" /translation="MAIVKATDQSFSAETSEGVVLADFWAPWCGPCKMIAPVLEELDQ EMGDKLKIVKIDVDENQETAGKYGVMSIPTLLVLKDGEVVETSVGFKPKEALQELVNK HL*" /label="trxA CDS" gene complement(2433602..2433916) /gene="trxA" /locus_tag="BSU_28500" /old_locus_tag="BSU28500" /label="trxA gene" promotor_-10 complement(2433942..2433961) /Source="Nicolas_upshift_promotors" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2433956) /Source="Nicolas_upshifts" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2433958..2434167) /Source="Nicolas_S_feature" /locus_tag="new_2913380_2913589_c" /HighExp="Etha, Salt, Gly, Sw, M9-stat, LPhT, BC, B60, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99984399999999996" /TUshortSig="SigB, SigA" /TUshortPSig="0.991, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1078" promotor_-35 complement(2433977..2433979) /Source="Nicolas_upshift_promotors" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2434061..2434171) /locus_tag="BSU_28509" /old_locus_tag="BSU28509" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="CDS C-terminal fragment" /db_xref="PSEUDO:SOX90589.1" /translation="MVKYMTVKRRCDLMLRTILMIIGAIVVIGAIIRFVF*" /label="CDS C-terminal fragment" gene complement(2434061..2434171) /locus_tag="BSU_28509" /old_locus_tag="BSU28509" /pseudo /label="gene" promotor_-10 complement(2434157..2434175) /Source="Nicolas_upshift_promotors" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="promotor_-10" upshifts complement(2434167) /Source="Nicolas_upshifts" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="upshifts" promotor_-35 complement(2434190..2434196) /Source="Nicolas_upshift_promotors" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="promotor_-35" CDS complement(2434239..2435726) /gene="abfB" /locus_tag="BSU_28510" /old_locus_tag="BSU28510" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 17827291, 18757805" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 17827291, 18757805; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exo-alpha-L-arabinofuranosidase" /protein_id="NP_390729.2" /db_xref="EnsemblGenomes-Gn:BSU28510" /db_xref="EnsemblGenomes-Tr:CAB14811" /db_xref="GOA:P94552" /db_xref="InterPro:IPR010720" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG11985" /db_xref="UniProtKB/Swiss-Prot:P94552" /translation="MSEHQAVIQTDIAKGTINKNIYGHFAEHLGRGIYEGIWVGTDSD IPNINGIRKDVLEALKQLHIPVLRWPGGCFADEYHWANGVGDRKTMLNTHWGGTIESN EFGTHEFMMLCELLECEPYICGNVGSGTVQEMSEWIEYMTFEEGTPMSDWRKQNGREE PWKLKYFGVGNENWGCGGNMHPEYYADLYRRFQTYVRNYSGNDIYKIAGGANVDDFNW TDVLMKKAAGLMDGLSLHYYTIPGDFWKGKGSATEFTEDEWFITMKKAKYIDELIQKH GTIMDRYDPEQRVGLIIDEWGTWFDPEPGTNPGFLYQQNTIRDALVAASHFHIFHQHC RRVQMANIAQTVNVLQAMILTEGERMLLTPTYHVFNMFKVHQDASLLATETMSADYEW NGETLPQISISASKQAEGDINITICNIDHQNKAEAEIELRGLHKAADHSGVILTAEKM NAHNTFDDPHHVKPESFRQYTLSKNKLKVKLPPMSVVLLTLRADS*" /label="abfB CDS" gene complement(2434239..2435726) /gene="abfB" /locus_tag="BSU_28510" /old_locus_tag="BSU28510" /label="abfB gene" S_feature complement(2435727..2435839) /Source="Nicolas_S_feature" /locus_tag="new_2915149_2915261_c" /HighExp="T0.30H, M40t90, M0t90, BC, M9-stat, T1.30H, T1.0H, T2.0H, T2.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1079" promotor_-10 complement(2435820..2435839) /Source="Nicolas_upshift_promotors" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="promotor_-10" upshifts complement(2435839) /Source="Nicolas_upshifts" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="upshifts" promotor_-35 complement(2435854..2435861) /Source="Nicolas_upshift_promotors" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="promotor_-35" CDS complement(2435943..2436920) /gene="etfA" /locus_tag="BSU_28520" /old_locus_tag="BSU28520" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 20059546, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 20059546, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="electron transfer flavoprotein (alpha subunit)" /protein_id="NP_390730.1" /db_xref="EnsemblGenomes-Gn:BSU28520" /db_xref="EnsemblGenomes-Tr:CAB14812" /db_xref="GOA:P94551" /db_xref="InterPro:IPR001308" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014730" /db_xref="InterPro:IPR014731" /db_xref="InterPro:IPR018206" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR033947" /db_xref="SubtiList:BG11934" /db_xref="UniProtKB/Swiss-Prot:P94551" /translation="MGKKVIVLGEIRDGELRNVTFEAIAAGRTISGDGEVIGVLIGEN VQSIAQELIHYGADKVLTAEDPKLKTYTADGYSQVMRGVIEQENPDSVIFGHTAMGKD LSPKLAARLQTGLISDAIDVSVTGGNVVFTRPIYSGKAFERVISTDPMIFATIRPNNI QASEKDTSRSGSIESIDVSLTDLRTVIQEVVKKTADGVDLSEAKIIVAGGRGVKSKEG FQPLQELAEVLGAAVGASRGACDADYCDYALQIGQTGKVVTPDLYIACGISGAIQHLA GMSNSKVIVAINKDPEADIFKIADYGIVGDLFEVVPLLTEEFKQLNIHS*" /label="etfA CDS" gene complement(2435943..2436920) /gene="etfA" /locus_tag="BSU_28520" /old_locus_tag="BSU28520" /label="etfA gene" downshifts complement(2435951) /Source="Nicolas_upshifts" /id="D1461" /incds=0 /nref=58 /ntot=179 /MaxReadThrough="2.43782" /MaxDrop="7.95053" /score="30.2462458" /energy="-13.5" /TU="NA" /idTUdmin="U2210" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2436956..2437729) /gene="etfB" /locus_tag="BSU_28530" /old_locus_tag="BSU28530" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10026281, 17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10026281, 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="electron transfer flavoprotein (beta subunit)" /protein_id="NP_390731.1" /db_xref="EnsemblGenomes-Gn:BSU28530" /db_xref="EnsemblGenomes-Tr:CAB14813" /db_xref="GOA:P94550" /db_xref="InterPro:IPR000049" /db_xref="InterPro:IPR012255" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014730" /db_xref="InterPro:IPR033948" /db_xref="SubtiList:BG11935" /db_xref="UniProtKB/Swiss-Prot:P94550" /translation="MNLFVLMKRTFDTEEKIVIETGKIQDDGAEWIINPYDEYAIEEA IQLKEKHGGTITAVTVGGEEAEKELRTALAMGCDQAVLINIEDDLDEPDQYSISQVLY HYMKDQEFDLILGGNVAIDGGSGQVAPRLAELLDIPCITTITKLEINGTDAEAERDVE GDVEKIKTTLPLLVTAQQGLNEPRYPSLPGIMKAKKKPLEELELDDLDLDEEDAEPKL KTIERFLPPKKEAGKLLQGEPAEQAKELVSLLRSEAKVI*" /label="etfB CDS" gene complement(2436956..2437729) /gene="etfB" /locus_tag="BSU_28530" /old_locus_tag="BSU28530" /label="etfB gene" CDS complement(2437744..2438520) /gene="fadB" /locus_tag="BSU_28540" /old_locus_tag="BSU28540" /EC_number="4.2.1.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-CoA hydratase" /protein_id="NP_390732.1" /db_xref="EnsemblGenomes-Gn:BSU28540" /db_xref="EnsemblGenomes-Tr:CAB14814" /db_xref="GOA:P94549" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12331" /db_xref="UniProtKB/Swiss-Prot:P94549" /translation="MNAISLAVDQFVAVLTIHNPPANALSSRILEELSSCLDQCETDA GVRSIIIHGEGRFFSAGADIKEFTSLKGNEDSSLLAERGQQLMERIESFPKPIIAAIH GAALGGGLELAMACHIRIAAEDAKLGLPELNLGIIPGFAGTQRLPRYVGTAKALELIG SGEPISGKEALDLGLVSIGAKDEAEVIEKAKALAAKFAEKSPQTLASLLELLYSNKVY SYEGSLKLEAKRFGEAFESEDAKEGIQAFLEKRKPQFKGE*" /label="fadB CDS" gene complement(2437744..2438520) /gene="fadB" /locus_tag="BSU_28540" /old_locus_tag="BSU28540" /label="fadB gene" downshifts 2437809 /Source="Nicolas_upshifts" /id="D1462" /incds=1 /nref=1 /ntot=21 /MaxReadThrough="0.92259" /MaxDrop="4.42725" /score="-8.29305955" /energy="-5.1" /TU="NA" /idTUdmin="U2203" /TUdmin=7767 /isTUend="FALSE" /label="downshifts" CDS complement(2438535..2439119) /gene="fadR" /locus_tag="BSU_28550" /old_locus_tag="BSU28550" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17189250, 18941141, 21398533, 24356978" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 18941141, 21398533, 24356978; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of fatty acids degradation [FadR-long-chain (C14-C20) acyl-CoAs]" /protein_id="NP_390733.1" /db_xref="EnsemblGenomes-Gn:BSU28550" /db_xref="EnsemblGenomes-Tr:CAB14815" /db_xref="GOA:P94548" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR013570" /db_xref="InterPro:IPR036271" /db_xref="PDB:1VI0" /db_xref="PDB:3WHB" /db_xref="PDB:3WHC" /db_xref="SubtiList:BG12330" /db_xref="UniProtKB/Swiss-Prot:P94548" /translation="MKQKRPKYMQIIDAAVEVIAENGYHQSQVSKIAKQAGVADGTIY LYFKNKEDILISLFKEKMGQFIERMEEDIKEKATAKEKLALVISKHFSLLAGDHNLAI VTQLELRQSNLELRQKINEILKGYLNILDGILTEGIQSGEIKEGLDVRLARQMIFGTI DETVTTWVMNDQKYDLVALSNSVLELLVSGIHNK*" /label="fadR CDS" gene complement(2438535..2439119) /gene="fadR" /locus_tag="BSU_28550" /old_locus_tag="BSU28550" /label="fadR gene" promotor_-10 complement(2439161..2439180) /Source="Nicolas_upshift_promotors" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2439161) /Source="Nicolas_upshifts" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2439193..2439200) /Source="Nicolas_upshift_promotors" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2439224..2440906) /gene="lcfA" /locus_tag="BSU_28560" /old_locus_tag="BSU28560" /EC_number="6.2.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17085570, 17189250, 21398533, 21673922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17085570, 17189250, 21398533, 21673922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="long chain acyl-CoA ligase (degradative)" /protein_id="NP_390734.1" /db_xref="EnsemblGenomes-Gn:BSU28560" /db_xref="EnsemblGenomes-Tr:CAB14816" /db_xref="GOA:P94547" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG11946" /db_xref="UniProtKB/Swiss-Prot:P94547" /translation="MQSQKPWLAEYPNDIPHELPLPNKTLQSILTDSAARFPDKTAIS FYGKKLTFHDILTDALKLAAFLQCNGLQKGDRVAVMLPNCPQTVISYYGVLFAGGIVV QTNPLYTEHELEYQLRDAQVSVIITLDLLFPKAIKMKTLSIVDQILITSVKDYLPFPK NILYPLTQKQKVHIDFDKTANIHTFASCMKQEKTELLTIPKIDPEHDIAVLQYTGGTT GAPKGVMLTHQNILANTEMCAAWMYDVKEGAEKVLGIVPFFHVYGLTAVMNYSIKLGF EMILLPKFDPLETLKIIDKHKPTLFPGAPTIYIGLLHHPELQHYDLSSIKSCLSGSAA LPVEVKQKFEKVTGGKLVEGYGLSEASPVTHANFIWGKNKPGSIGCPWPSTDAAIYSE ETGELAAPYEHGEIIVKGPQVMKGYWNKPEETAAVLRDGWLFTGDMGYMDEEGFFYIA DRKKDIIIAGGYNIYPREVEEALYEHEAIQEIVVAGVPDSYRGETVKAFVVLKKGAKA DTEELDAFARSRLAPYKVPKAYEFRKELPKTAVGKILRRRLLEEETENHHIK*" /label="lcfA CDS" gene complement(2439224..2440906) /gene="lcfA" /locus_tag="BSU_28560" /old_locus_tag="BSU28560" /label="lcfA gene" misc_feature complement(2440935..2440954) /Source="Nicolas_upshift_promotors" /id="U2211" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.411588411588412" /psig="0.985014985014985" /xcortree=352 /SigmaFactorBS="tatgagaaaaagaaagatttacctttctttttcttttttttg ccgtccaTCTGCTATAATGATAAGGTGgatctctaaaatcgaaaggggaggttttatg c" /listShort="lcfA, fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2440943) /Source="Nicolas_upshifts" /id="U2211" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.411588411588412" /psig="0.985014985014985" /xcortree=352 /SigmaFactorBS="tatgagaaaaagaaagatttacctttctttttcttttttttg ccgtccaTCTGCTATAATGATAAGGTGgatctctaaaatcgaaaggggaggttttatg c" /listShort="lcfA, fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2441031) /Source="Nicolas_upshifts" /id="D1463" /incds=0 /nref=8 /ntot=101 /MaxReadThrough="2.17789" /MaxDrop="3.3655" /score="10.932726" /energy="-9.8" /TU="U2212" /idTUdmin="U2212" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2441095..2441499) /gene="yshE" /locus_tag="BSU_28570" /old_locus_tag="BSU28570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390735.1" /db_xref="EnsemblGenomes-Gn:BSU28570" /db_xref="EnsemblGenomes-Tr:CAB14817" /db_xref="GOA:P94546" /db_xref="InterPro:IPR007140" /db_xref="SubtiList:BG12329" /db_xref="UniProtKB/Swiss-Prot:P94546" /translation="MSDFWENELVEIAAYYSVAVLCLVLFLTVFELVTAYKNWEEIQK GNLAVAMATGGKILGIANVFQHSISQHNSLLQMIGWGVYGFVMLLISYFIFEFLTPRF KIDQEIENDNRAVGFISFVISVGLSFVVAAGI*" /label="yshE CDS" gene complement(2441095..2441499) /gene="yshE" /locus_tag="BSU_28570" /old_locus_tag="BSU28570" /label="yshE gene" downshifts complement(2441097) /Source="Nicolas_upshifts" /id="D1464" /incds=0 /nref=1 /ntot=75 /MaxReadThrough="3.74343" /MaxDrop="2.92029" /score="10.932726" /energy="-9.8" /TU="U2212" /idTUdmin="U2212" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" CDS complement(2441514..2443871) /gene="mutSB" /locus_tag="BSU_28580" /old_locus_tag="BSU28580" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11254128, 12719520, 22333191, 27799325" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11254128, 12719520, 22333191, 27799325; Product type f: factor" /codon_start=1 /transl_table=11 /product="homologous recombination factor" /protein_id="NP_390736.1" /db_xref="EnsemblGenomes-Gn:BSU28580" /db_xref="EnsemblGenomes-Tr:CAB14818" /db_xref="GOA:P94545" /db_xref="InterPro:IPR000432" /db_xref="InterPro:IPR002625" /db_xref="InterPro:IPR005747" /db_xref="InterPro:IPR007696" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036063" /db_xref="InterPro:IPR036187" /db_xref="SubtiList:BG12328" /db_xref="UniProtKB/Swiss-Prot:P94545" /translation="MQQKVLSALEFHKVKEQVIGHAASSLGKEMLLELKPSASIDEIK KQLDEVDEASDIIRLRGQAPFGGLVDIRGALRRAEIGSVLSPSEFTEISGLLYAVKQM KHFITQMAEDGVDIPLIHQHAEQLITLSDLERDINSCIDDHGEVLDHASETLRGIRTQ LRTLESRVRDRLESMLRSSSASKMLSDTIVTIRNDRFVIPVKQEYRSSYGGIVHDTSS SGATLFIEPQAIVDMNNSLQQAKVKEKQEIERILRVLTEKTAEYTEELFLDLQVLQTL DFIFAKARYAKAVKATKPIMNDTGFIRLKKARHPLLPPDQVVANDIELGRDFSTIVIT GPNTGGKTVTLKTLGLLTLMAQSGLHIPADEGSEAAVFEHVFADIGDEQSIEQSLSTF SSHMVNIVGILEQVNENSLVLFDELGAGTDPQEGAALAMSILDDVHRTNARVLATTHY PELKAYGYNREGVMNASVEFDIETLSPTYKLLIGVPGRSNAFEISKRLGLPDHIIGQA KSEMTAEHNEVDTMIASLEQSKKRAEEELSETESIRKEAEKLHKELQQQIIELNSKKD KMLEEAEQQAAEKVKAAMKEAEDIIHELRTIKEEHKSFKDHELINAKKRLEGAMPAFE KSKKPEKPKTQKRDFKPGDEVKVLTFGQKGTLLEKTGGNEWNVQIGILKMKVKEKDLE FIKSAPEPKKEKMITAVKGKDYHVSLELDLRGERYENALSRVEKYLDDAVLAGYPRVS IIHGKGTGALRKGVQDLLKNHRSVKSSRFGEAGEGGSGVTVVELK*" /label="mutSB CDS" gene complement(2441514..2443871) /gene="mutSB" /locus_tag="BSU_28580" /old_locus_tag="BSU28580" /label="mutSB gene" CDS complement(2443892..2445604) /gene="polX" /locus_tag="BSU_28590" /old_locus_tag="BSU28590" /EC_number="2.7.7.7" /EC_number="3.1.11.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:18776221, 18938175, 28254425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18776221, 18938175, 28254425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase/3'-5' exonuclease X" /protein_id="NP_390737.1" /db_xref="EnsemblGenomes-Gn:BSU28590" /db_xref="EnsemblGenomes-Tr:CAB14819" /db_xref="GOA:P94544" /db_xref="InterPro:IPR002054" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR010996" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR022311" /db_xref="InterPro:IPR027421" /db_xref="InterPro:IPR029398" /db_xref="InterPro:IPR037160" /db_xref="SubtiList:BG12327" /db_xref="UniProtKB/Swiss-Prot:P94544" /translation="MHKKDIIRLLETIAVYMELKGDNPFKVSAFRKAAAALEQDDRSL SEMDDMMSLSGIGKGTYSVIKEYIDEGKSSTLESLQKEVPEGLVPLLKLPGLGGKKIA KLYKELGVHDAESLKEACEQQKVQGLAGFGKKSEEKILQALGEAGKQPERFPIGYALR IAREIEEHLSQFTHIIKFSRAGSLRRARETVKDLDYIIATDHPAEVREQLLELPNIKS VIASGDTKVSVILSFEYETSVDFRLVTEEQFPTTLHHFTGSKDHNIKMRQIAKERGER ISEYGVETVETGEIKTFPSEREFYAHFGLPLIPPEIRESGQEVETYSDSIELIELGQI KGDLHMHSTWSDGAFSIREMAEACIKKGYQYMAITDHSQYLKVANGLTAERLKQQAKE IDALNAEFENFRILKGVEMDILPDGTLDYDDDVLAEMDIVIASIHSSFNQPEHVIMKR LETALTNKHVDIIAHPTGRLIGRRAGYEIDIDQLIELARKTNTALELNANPARLDLRT EHLMKANEQGVTLVINTDAHNIEMLDDMKTGVTAARKGWTETKNVLNARSLKDVEAFL KRND*" /label="polX CDS" gene complement(2443892..2445604) /gene="polX" /locus_tag="BSU_28590" /old_locus_tag="BSU28590" /label="polX gene" S_feature complement(2445605..2445677) /Source="Nicolas_S_feature" /locus_tag="new_2925027_2925099_c" /HighExp="Cold, LPhT, LBGstat, H2O2, dia15, G180, G135, Sw, G150, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1080" CDS complement(2445678..2446211) /gene="yshB" /locus_tag="BSU_28600" /old_locus_tag="BSU28600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390738.1" /db_xref="EnsemblGenomes-Gn:BSU28600" /db_xref="EnsemblGenomes-Tr:CAB14820" /db_xref="GOA:P94543" /db_xref="InterPro:IPR003825" /db_xref="SubtiList:BG12326" /db_xref="UniProtKB/Swiss-Prot:P94543" /translation="MLDIIILILLLMGTLLGLKRGFILQFIRLTSFILSIAFAALFYK NVAPHLHWIPAPDFSAGQPALSFFTGNLEAAYYNAIAFIVLFIIAKILLRIIGSFLSI VAGIPVIKQINQMLGAVLGFLEVYLFTFVLLYVASVLPVDALQQMMGQSSLANVIINH TPYLSGLLQELWTQYGA*" /label="yshB CDS" gene complement(2445678..2446211) /gene="yshB" /locus_tag="BSU_28600" /old_locus_tag="BSU28600" /label="yshB gene" CDS complement(2446218..2446475) /gene="zapA" /locus_tag="BSU_28610" /old_locus_tag="BSU28610" /experiment="publication(s) with functional evidences, PMID:15317782, 16796675, 18588879, 20711458, 24097947, 26258635" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317782, 16796675, 18588879, 20711458, 24097947, 26258635; Product type r : regulator" /codon_start=1 /transl_table=11 /product="regulator of cell division" /protein_id="NP_390739.1" /db_xref="EnsemblGenomes-Gn:BSU28610" /db_xref="EnsemblGenomes-Tr:CAB14821" /db_xref="GOA:P94542" /db_xref="InterPro:IPR007838" /db_xref="InterPro:IPR023688" /db_xref="InterPro:IPR036192" /db_xref="SubtiList:BG12325" /db_xref="UniProtKB/Swiss-Prot:P94542" /translation="MSDGKKTKTTVDIYGQHFTIVGEESRAHMRYVAGIVDDKMREIN EKNPYLDINKLAVLTAVNVVHDYVKLQEKCEKLERQLKEKD*" /label="zapA CDS" gene complement(2446218..2446475) /gene="zapA" /locus_tag="BSU_28610" /old_locus_tag="BSU28610" /label="zapA gene" promotor_-10 complement(2446502..2446521) /Source="Nicolas_upshift_promotors" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2446518) /Source="Nicolas_upshifts" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2446533..2446540) /Source="Nicolas_upshift_promotors" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2446558..2446577 /Source="Nicolas_upshift_promotors" /id="U2213" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.999000999001" /xcortree=2131 /SigmaFactorBS="gttcttatcataacacgtttattaaatgaatggaaagacgag cctcccgctgtTATGATACACTGGTATATACagcgaaaagtgtaaaaaaaggagatta t" /listShort="rnhC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2446565 /Source="Nicolas_upshifts" /id="U2213" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.999000999001" /xcortree=2131 /SigmaFactorBS="gttcttatcataacacgtttattaaatgaatggaaagacgag cctcccgctgtTATGATACACTGGTATATACagcgaaaagtgtaaaaaaaggagatta t" /listShort="rnhC" /GFF_Attribute="listLong" /label="upshifts" CDS 2446609..2447550 /gene="rnhC" /locus_tag="BSU_28620" /old_locus_tag="BSU28620" /EC_number="3.1.26.4" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9888800, 10094689, 12794188, 23882084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9888800, 10094689, 12794188, 23882084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease HIII" /protein_id="NP_390740.1" /db_xref="EnsemblGenomes-Gn:BSU28620" /db_xref="EnsemblGenomes-Tr:CAB14822" /db_xref="GOA:P94541" /db_xref="InterPro:IPR001352" /db_xref="InterPro:IPR004641" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR024567" /db_xref="InterPro:IPR024568" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12324" /db_xref="UniProtKB/Swiss-Prot:P94541" /translation="MSHSVIKVSLSAIDQMKMTYSGSLTASVPQGAVFQAKPPGCTIT AYQSGKVLFQGKNAAAESARWGTAEPQEKKKTAKKPADPRYAPPADIAGMSVIGSDEV GTGDYFGPMTVVCAYVDKTMLPLMKELGVKDSKDLKDPQIIEIARNLIKTIPYSLLVL KNEKYNSMQEKGMSQGKMKALLHNQAITHLLRKLDGVKPEAILIDQFAEPGVYFNHLK GRDIVKERTYFSTKAEGIHLAVAAASIIARYSFLMEMDKLSRAAGMTLPKGAGPHVDE AAAKLILKKGASALRTFTKLHFANTQKAQRLADKKRS*" /label="rnhC CDS" gene 2446609..2447550 /gene="rnhC" /locus_tag="BSU_28620" /old_locus_tag="BSU28620" /label="rnhC gene" promotor_-10 complement(2447282..2447301) /Source="Nicolas_upshift_promotors" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2447297) /Source="Nicolas_upshifts" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2447315..2447322) /Source="Nicolas_upshift_promotors" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2447533 /Source="Nicolas_upshifts" /id="D1465" /incds=0 /nref=150 /ntot=232 /MaxReadThrough="1.71535" /MaxDrop="5.25365" /score="25.6336933" /energy="-13.7" /TU="NA" /idTUdmin="U2213" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2447565) /Source="Nicolas_upshifts" /id="D1466" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="2.4685" /MaxDrop="5.29665" /score="-4.45611985" /energy="-14.9" /TU="NA" /idTUdmin="U2216" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(2447586..2450000) /gene="pheT" /locus_tag="BSU_28630" /old_locus_tag="BSU28630" /EC_number="6.1.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:811647, 2127701, 2492510, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 811647, 2127701, 2492510, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenylalanyl-tRNA synthetase (beta subunit)" /protein_id="NP_390741.1" /db_xref="EnsemblGenomes-Gn:BSU28630" /db_xref="EnsemblGenomes-Tr:CAB14823" /db_xref="GOA:P17922" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR004532" /db_xref="InterPro:IPR005121" /db_xref="InterPro:IPR005146" /db_xref="InterPro:IPR005147" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR020825" /db_xref="InterPro:IPR033714" /db_xref="InterPro:IPR036690" /db_xref="SubtiList:BG10875" /db_xref="UniProtKB/Swiss-Prot:P17922" /translation="MFVSYKWLEDYVDLKGMDPAVLAEKITRAGIEVEGIEYKGEGIK GVVIGHVLEREQHPNADKLNKCLVDIGAEAPVQIICGAPNVDKGQKVAVATVGAVLPG NFKIKKAKLRGEESNGMICSLQELGIESKLVAKEYAEGIFVFPNDAETGSDALAALQL DDAILELGLTPNRADAMNMLGVAYEVAAILDTEVKLPQTDYPAASEQASDYISVKIED QEANPLYTAKIIKNVTIAPSPLWMQTKLMNAGIRPHNNVVDITNFVLLEYGQPLHAFD YDRFGSKEVVVRKAAENEMIVTLDDQERKLSADHLVITNGTKAQAVAGVMGGAESEVQ EDTKTILLEAAYFNGQKVRKASKDLGLRSESSVRFEKGIDPARVRLAAERAAQLIHLY AGGEVLAGTVEEDHLTIEANNIHVSADKVSSVLGLTISKEELISIYKRLGFTVGEADD LLVVTVPSRRGDITIEEDLIEEAARLYGYDNIPSTLPETAGTTGGLTPYQAKRRKVRR FLEGAGLSQAITYSLTNEKKATAFAIEKSLNTVLALPMSEERSILRHSLVPNLLDSVS YNLARQTDSVALYEVGSVFLTKEEDTKPVETERVAGAVTGLWRKQLWQGEKKPVDFFV VKGIVEGLLDKLNVLDSIEFVQSERKQLHPGRTANILLNGSLIGFIGQVHPSLEKELD IKETYVFELDLHALLAAETAPLVYTAIPKYPSVTRDIALVTDKTVTSGQLESVIKEAG GKLLKEVTVFDVYEGEHMEEGKKSVAFSLQYVNPEQTLTEEEVTKAHSKVLKALEDTY QAVLRG*" /label="pheT CDS" gene complement(2447586..2450000) /gene="pheT" /locus_tag="BSU_28630" /old_locus_tag="BSU28630" /label="pheT gene" downshifts complement(2447609) /Source="Nicolas_upshifts" /id="D1467" /incds=0 /nref=214 /ntot=255 /MaxReadThrough="3.98669" /MaxDrop="7.11892" /score="32.4736491" /energy="-14.7" /TU="NA" /idTUdmin="U2216" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2450016..2451050) /gene="pheS" /locus_tag="BSU_28640" /old_locus_tag="BSU28640" /EC_number="6.1.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:811647, 2127701, 2492510, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 811647, 2127701, 2492510, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenylalanyl-tRNA synthetase (alpha subunit)" /protein_id="NP_390742.1" /db_xref="EnsemblGenomes-Gn:BSU28640" /db_xref="EnsemblGenomes-Tr:CAB14824" /db_xref="GOA:P17921" /db_xref="InterPro:IPR002319" /db_xref="InterPro:IPR004188" /db_xref="InterPro:IPR004529" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR022911" /db_xref="SubtiList:BG10874" /db_xref="UniProtKB/Swiss-Prot:P17921" /translation="MEEKLKQLEQEALEQVEAASSLKVVNDIRVQYLGKKGPITEVLR GMGKLSAEERPKMGALANEVRERIANAIADKNEKLEEEEMKQKLAGQTIDVTLPGNPV AVGGRHPLTVVIEEIEDLFIGMGYTVEEGPEVETDYYNFESLNLPKEHPARDMQDSFY ITEETLMRTQTSPVQTRTMEKHEGKGPVKIICPGKVYRRDNDDATHSHQFMQIEGLVV DKNISMSDLKGTLELVAKKMFGQDREIRLRPSFFPFTEPSVEVDVTCFKCGGNGCSVC KGTGWIEILGAGMVHPNVLKMAGFDPKEYQGFAFGMGVERIAMLKYGIDDIRHFYTND VRFISQFKQA*" /label="pheS CDS" gene complement(2450016..2451050) /gene="pheS" /locus_tag="BSU_28640" /old_locus_tag="BSU28640" /label="pheS gene" S_feature complement(2451051..2451371) /Source="Nicolas_S_feature" /locus_tag="new_2930473_2930793_c" /HighExp="HPh, Cold, GM 15, GM 10, Sw, C30, G150, MG-0.2, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1081" CDS 2451132..2451338 /locus_tag="BSU_28645" /old_locus_tag="BSU28645" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513995.1" /translation="MWPRYHPYFRQTDAVVSFIDITESDSGSPLRAVYAVPATTQEVK PISGCVKNALSQRHFLPGKQLIRN*" /label="hypothetical protein CDS" gene 2451132..2451338 /locus_tag="BSU_28645" /old_locus_tag="BSU28645" /label="gene" S_feature 2451361..2451625 /Source="Nicolas_S_feature" /locus_tag="new_2930783_2931047" /HighExp="S8, S7, S6, BT, C30, B36, S5, Pyr, C90, Glucon" /AntisenseName="ysgA" /AntisenseCor="-0.23049778674462801" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.519" /TUlongSig="NA" /TUlongPSig="NA" /label="S1082" upshifts 2451361 /Source="Nicolas_upshifts" /id="U2215" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.411588411588412" /psig="0.519480519480519" /xcortree=1240 /SigmaFactorBS="ggcattttctccctggaaagcagttgatcagaaattgaggtc ctctgtcacggtttttgaaatattaTGTTCTATTATAGAGaaatccaacgcttggcgc a" /listShort="S1082" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2451366..2451385) /Source="Nicolas_upshift_promotors" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2451368..2451382 /Source="Nicolas_upshift_promotors" /id="U2215" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.411588411588412" /psig="0.519480519480519" /xcortree=1240 /SigmaFactorBS="ggcattttctccctggaaagcagttgatcagaaattgaggtc ctctgtcacggtttttgaaatattaTGTTCTATTATAGAGaaatccaacgcttggcgc a" /listShort="S1082" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2451371) /Source="Nicolas_upshifts" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2451400..2451403) /Source="Nicolas_upshift_promotors" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2451405..2452151) /gene="rlmBB" /locus_tag="BSU_28650" /old_locus_tag="BSU28650" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17114254, 24809820, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal RNA methylase" /protein_id="NP_390743.1" /db_xref="EnsemblGenomes-Gn:BSU28650" /db_xref="EnsemblGenomes-Tr:CAB14825" /db_xref="GOA:P94538" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR013123" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="InterPro:IPR029064" /db_xref="SubtiList:BG12323" /db_xref="UniProtKB/Swiss-Prot:P94538" /translation="MKQIESAKNQKVKDWKKLHTKKERTKTNTFLIEGEHLVEEALKS PGIVKEILVKDETRIPSDLETGIQCYMLSEDAFSAVTETETPQQIAAVCHMPEEKLAT ARKVLLIDAVQDPGNLGTMIRTADAAGLDAVVLGDGTADAFNGKTLRSAQGSHFHIPV VRRNLPSYVDELKAEGVKVYGTALQNGAPYQEIPQSESFALIVGNEGAGVDAALLEKT DLNLYVPLYGQAESLNVAVAAAILVYHLRG*" /label="rlmBB CDS" gene complement(2451405..2452151) /gene="rlmBB" /locus_tag="BSU_28650" /old_locus_tag="BSU28650" /label="rlmBB gene" promotor_-10 complement(2452178..2452197) /Source="Nicolas_upshift_promotors" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="promotor_-10" promotor_-35 2452184..2452190 /Source="Nicolas_upshift_promotors" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2452191) /Source="Nicolas_upshifts" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="upshifts" promotor_-10 2452204..2452215 /Source="Nicolas_upshift_promotors" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2452211..2452217) /Source="Nicolas_upshift_promotors" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="promotor_-35" upshifts 2452218 /Source="Nicolas_upshifts" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="upshifts" CDS 2452270..2452485 /gene="sspI" /locus_tag="BSU_28660" /old_locus_tag="BSU28660" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8171126, 10806362, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8171126, 10806362, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_390744.1" /db_xref="EnsemblGenomes-Gn:BSU28660" /db_xref="EnsemblGenomes-Tr:CAB14826" /db_xref="GOA:P94537" /db_xref="InterPro:IPR017525" /db_xref="SubtiList:BG12318" /db_xref="UniProtKB/Swiss-Prot:P94537" /translation="MDLNLRHAVIANVTGNNQEQLEHTIVDAIQSGEEKMLPGLGVLF EVIWQHASESEKNEMLKTLEGGLKPAE*" /label="sspI CDS" gene 2452270..2452485 /gene="sspI" /locus_tag="BSU_28660" /old_locus_tag="BSU28660" /label="sspI gene" S_feature complement(2452467..2453879) /Source="Nicolas_S_feature" /locus_tag="new_2931889_2933301_c" /HighExp="S6, S8, S7, BT, S5, C30, B36, S4, B60, C90" /AntisenseName="ysfB" /AntisenseCor="0.46970634471519201" /AntisenseRegPval="-15.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1083" promotor_-35 2452496..2452503 /Source="Nicolas_upshift_promotors" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2452519..2452538 /Source="Nicolas_upshift_promotors" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2452527 /Source="Nicolas_upshifts" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="upshifts" CDS 2452554..2453660 /gene="ysfB" /locus_tag="BSU_28670" /old_locus_tag="BSU28670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (glycolate degradation operon)" /protein_id="NP_390745.2" /db_xref="EnsemblGenomes-Gn:BSU28670" /db_xref="EnsemblGenomes-Tr:CAB14827" /db_xref="InterPro:IPR008599" /db_xref="InterPro:IPR025736" /db_xref="SubtiList:BG12319" /db_xref="UniProtKB/Swiss-Prot:P94536" /translation="MFLQPLLAKKIIAEVKKMYEREVIIVNTDGLIMAGTNDERVGQF HEGALICAKERRSVIITKEDETRLKGVKAGINLPVFFDHDVIAVFGLTGEPAEIQPFG ELLRKMTELFIKESRHLEQSQWRERMLESFMIDWLQLKEWSPSFLEKAQLLGVDLSSR RQMILIQGYEWSPHDIEQMARSWKSSYPADLFIRWGNERILINHEVPQHEQRDRLLRK ILHICSFANTASSQYTAAGAGRAVASSSLTDSYEQAEKALAVSLKRKTPIFEEDLKLD MCLTEISPGTRNEFPQRVLGKALEHQELMNTIRTFFHHDLSLKQTAEDMHIHINTLRY RLAKAEQLTGLRFDRTEDVVTMYVALYFLDQDTK*" /label="ysfB CDS" gene 2452554..2453660 /gene="ysfB" /locus_tag="BSU_28670" /old_locus_tag="BSU28670" /label="ysfB gene" promotor_-35 2453696..2453699 /Source="Nicolas_upshift_promotors" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2453715..2453734 /Source="Nicolas_upshift_promotors" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2453719 /Source="Nicolas_upshifts" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="upshifts" CDS 2453763..2455175 /gene="glcD" /locus_tag="BSU_28680" /old_locus_tag="BSU28680" /EC_number="1.1.99.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8606183, 25217009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycolate oxidase subunit" /protein_id="NP_390746.1" /db_xref="EnsemblGenomes-Gn:BSU28680" /db_xref="EnsemblGenomes-Tr:CAB14828" /db_xref="GOA:P94535" /db_xref="InterPro:IPR004113" /db_xref="InterPro:IPR004490" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR016164" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR016171" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12320" /db_xref="UniProtKB/Swiss-Prot:P94535" /translation="MITKDVKEQLIQVSGPENFDDSNAGRLVYSYDATPQYQSMPDAV IAPRNTDEISRILTICSEHRVPIVPRGSGTNLCGGTCPTEGGLVLLFKHMNQILEIDE ENLTATVQPGVITLDMIRAVESKGLFYPPDPSSMKISTIGGNINENSGGLRGLKYGVT RDYVIGLEVVLANGDIIRTGGKLAKDVAGYDLTRLFVGSEGTLGIVTEAIVKLVPKPE TKKTLLALYENIDAAAQTVSDIIAAKIIPATLEFLDQPTLLVIEDYAKIGLPTSAKAV LLIEQDGPFETVERDMEKIEAICKKGDAVSVQTAQTEEEAFALTEARRSALSALARLK PTTILEDATVPRSEIANMVKAINDIAAKYDISICTFGHAGDGNLHPTCTTDIRNKDEM ERVEQAFAEIFEKAIELGGTITGEHGVGEMKAPYLEMKLKKEGIDAMKALKAAFDPRN ILNPGKMFAKDARKRVVAER*" /label="glcD CDS" gene 2453763..2455175 /gene="glcD" /locus_tag="BSU_28680" /old_locus_tag="BSU28680" /label="glcD gene" promotor_-10 complement(2453865..2453884) /Source="Nicolas_upshift_promotors" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2453879) /Source="Nicolas_upshifts" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2453897..2453906) /Source="Nicolas_upshift_promotors" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2455172..2456506 /gene="glcF" /locus_tag="BSU_28690" /old_locus_tag="BSU28690" /EC_number="1.1.99.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8606183, 25217009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycolate oxidase (iron-sulfur subunit)" /protein_id="NP_390747.1" /db_xref="EnsemblGenomes-Gn:BSU28690" /db_xref="EnsemblGenomes-Tr:CAB14829" /db_xref="GOA:P94534" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012257" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="SubtiList:BG12321" /db_xref="UniProtKB/Swiss-Prot:P94534" /translation="MTTEKEMKQIQNEFKERMDEGELLNCMRCGFCLPSCPTYIESGF QETHSPRGRIALMKAVADGMIEPDEDVERSLSLCLGCRACEPVCPSGVKYGQLLEEAR DIIHQNKKHSLGERVMRKTAFHELFPHQNRMRSAVSLIGLYQRSGLQTAVRKSGMLRV LPEHLRTMEAVLPDVPKSKDMKHRPRFLPSIGPMKKRVAFFSGCLMDTMFLPTNNATL KLLQLAGCDIVIPPEQACCGALHGHSGEKNTGKELAKQNIAAFEALDVDAVITNAGGC GAFLTEYDHLLKDDPEWSERAAAFVQKLKDFSSVLVELDFHQMDLALETPQVVTYQDS CHLRNVMHTSLEPRQLLKSIKGAEFKEMEKADSCCGSAGIYNIVEVEMSMKILDSKMA AVKATEAILIVTANPGCLLQMKLGIEREGLSGKVRAVHLADLLLEAAGHKTS*" /label="glcF CDS" gene 2455172..2456506 /gene="glcF" /locus_tag="BSU_28690" /old_locus_tag="BSU28690" /label="glcF gene" Polymorphism join(2456205,2456207) /Source="geneious" /ID="SNP_BsDelta6_2935628_2935628" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position=1035 /Change="C -> T" /Codon_Change="CTC -> CTT" /Coverage=142 /locus_tag="BSU_28690" /Protein_Effect="None" /Reference_Frequency="1.4%" /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=140 /comment="silent" /modified_by="User" / /label="Polymorphism_Delta6" downshifts 2456504 /Source="Nicolas_upshifts" /id="D1468" /incds=0 /nref=48 /ntot=148 /MaxReadThrough="3.07756" /MaxDrop="5.25031" /score="4.55188138" /energy="-14.3" /TU="U2220" /idTUdmin="U2220" /TUdmin="-181" /isTUend="FALSE" /label="downshifts" downshifts complement(2456543) /Source="Nicolas_upshifts" /id="D1469" /incds=0 /nref=27 /ntot=221 /MaxReadThrough="1.51397" /MaxDrop="5.34865" /score="-5.71907967" /energy="-14.3" /TU="NA" /idTUdmin="U2222" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2456545..2456787) /gene="ysfE" /locus_tag="BSU_28700" /old_locus_tag="BSU28700" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390748.1" /db_xref="EnsemblGenomes-Gn:BSU28700" /db_xref="EnsemblGenomes-Tr:CAB14830" /db_xref="InterPro:IPR025870" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12322" /db_xref="UniProtKB/Swiss-Prot:P94533" /translation="MALNTRESARDITALDIPDTSASNTFEIGFVTENVEAVIKRMRE QGVSIIGEPKVKPWGQTVAYIADPDGHYIEICSPME*" /label="ysfE CDS" gene complement(2456545..2456787) /gene="ysfE" /locus_tag="BSU_28700" /old_locus_tag="BSU28700" /label="ysfE gene" S_feature complement(2456788..2456959) /Source="Nicolas_S_feature" /locus_tag="new_2936210_2936381_c" /HighExp="Sw, M0t90, M40t90, M9-stat, T2.0H, BC, T0.30H, Lbstat, T2.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1084" CDS complement(2456847..2457017) /locus_tag="BSU_28709" /old_locus_tag="BSU28709" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513996.1" /translation="MGADVERSELKDGSIYTGLEGLLKMLRGVGNESINEISYSIRIG QQAGYSFFTGIF*" /label="hypothetical protein CDS" gene complement(2456847..2457017) /locus_tag="BSU_28709" /old_locus_tag="BSU28709" /label="gene" CDS complement(2456960..2458756) /gene="cstA" /locus_tag="BSU_28710" /old_locus_tag="BSU28710" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 1848300, 17320232, 19682248" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 1848300, 17320232, 19682248; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="carbon starvation-induced membrane protein" /protein_id="NP_390749.2" /db_xref="EnsemblGenomes-Gn:BSU28710" /db_xref="EnsemblGenomes-Tr:CAB14831" /db_xref="GOA:P94532" /db_xref="InterPro:IPR003706" /db_xref="InterPro:IPR025299" /db_xref="SubtiList:BG11924" /db_xref="UniProtKB/Swiss-Prot:P94532" /translation="MNAVTIVIASMCILAIAYRLYGTFMMVKVLKVNDDKPTPAHALE DGKDYVPTNKWVSFGHHFAAIAAAGPLVGPILAAQFGYLPGLLWLLIGAVIGGAVHDI VVLFASMRKNGKSLSEVAKDELGPVAGFCTGLSMLFIITITMAGLSMVVLHALERNPW GTFAVGITIPIAMGVGLFYKKTGNLKLASTVGFLFLMAGVFIGPWVQTTALGDFLTLD TKTLAIALPVYAFFAAALPVWLLLAPRDYLSSFMKIGVFIALIVGVFVVNPSIPFPAF TEFVKGGGPVLAGPVWPFISITIACGAISGFHAFVGSGTTPKMLNKWSDMKPVAFGAM LVECLVGIMALIAATALQPADYFAINSTPEVFRTLGMNVVHLPELSGEIGLDLEGRTG GAVTLAVGMTYIFTGMPFFSHLASYFFQFVIMFEAVFILTAIDAGTRVARYLIQDFFG EVYKPLKKTDWIPGSVFASALACLMWGYLLYSGDIGSIWALFGVSNQLMASVGLIIGA TIVLKIADKRRYILTCLIPLAYLYVTVNYAGYWMVRNVYLNPEAAGYSVLNGVLSIIM LVLGFIIIVAAVKKWAQMWKDPSLRMEASIPG*" /label="cstA CDS" gene complement(2456960..2458756) /gene="cstA" /locus_tag="BSU_28710" /old_locus_tag="BSU28710" /label="cstA gene" promotor_-10 complement(2457062..2457080) /Source="Nicolas_upshift_promotors" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2457080) /Source="Nicolas_upshifts" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2457092..2457100) /Source="Nicolas_upshift_promotors" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2458753 /Source="Nicolas_upshifts" /id="D1470" /incds=0 /nref=4 /ntot=49 /MaxReadThrough="0.92122" /MaxDrop="3.18629" /score="12.2066828" /energy="-15.2" /TU="NA" /idTUdmin="U2220" /TUdmin=2068 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2458781..2458800) /Source="Nicolas_upshift_promotors" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2458791) /Source="Nicolas_upshifts" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2458815..2458821) /Source="Nicolas_upshift_promotors" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2458851..2458907) /Source="Nicolas_S_feature" /locus_tag="new_2938273_2938329_c" /HighExp="BC, Sw, M40t90, T1.30H, M0t90, T1.0H, T0.30H, Lbstat, T2.30H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1085" downshifts complement(2458875) /Source="Nicolas_upshifts" /id="D1471" /incds=0 /nref=12 /ntot=40 /MaxReadThrough="0.655710000000001" /MaxDrop="5.03461" /score="9.68754272" /energy="-10.5" /TU="NA" /idTUdmin="U2224" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2458908..2460410) /gene="abfA" /locus_tag="BSU_28720" /old_locus_tag="BSU28720" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 12777810, 14973026, 16233670, 18757805" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 12777810, 14973026, 16233670, 18757805; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-L-arabinofuranosidase" /protein_id="NP_390750.2" /db_xref="EnsemblGenomes-Gn:BSU28720" /db_xref="EnsemblGenomes-Tr:CAB14832" /db_xref="GOA:P94531" /db_xref="InterPro:IPR010720" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG11900" /db_xref="UniProtKB/Swiss-Prot:P94531" /translation="MKKARMIVDKEYKIGEVDKRIYGSFIEHMGRAVYEGIYEPDHPE ADEDGFRKDVQSLIKELQVPIIRYPGGNFLSGYNWEDGVGPVENRPRRLDLAWQTTET NEVGTNEFLSWAKKVNTEVNMAVNLGTRGIDAARNLVEYCNHPKGSYWSDLRRSHGYE QPYGIKTWCLGNEMDGPWQIGHKTADEYGRLAAETAKVMKWVDPSIELVACGSSNSGM PTFIDWEAKVLEHTYEHVDYISLHTYYGNRDNNLPNYLARSMDLDHFIKSVAATCDYV KAKTRSKKTINLSLDEWNVWYHSNEADKKVEPWITARPILEDIYNFEDALLVGSLLIT MLQHADRVKIACLAQLVNVIAPIMTEKGGEAWRQPIFYPYMHASVYGRGESLKPLISS PKYDCSDFTDVPYVDAAVVYSEEEETLTIFAVNKAEDQMETEISLRGFESYQIAEHIV LEHQDIKATNQHNRKNVVPHSNGSSSVSENGLTAHFTPLSWNVIRLKKQS*" /label="abfA CDS" gene complement(2458908..2460410) /gene="abfA" /locus_tag="BSU_28720" /old_locus_tag="BSU28720" /label="abfA gene" downshifts complement(2460281) /Source="Nicolas_upshifts" /id="D1472" /incds=1 /nref=7 /ntot=15 /MaxReadThrough="3.81491" /MaxDrop="6.33773" /score="2.73497974" /energy="-14.2" /TU="U2224,U2225" /idTUdmin="U2224" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" promotor_no_box complement(2460385..2460485) /Source="Nicolas_upshift_promotors" /id="U2224" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.017982017982018" /xcortree=1474 /SigmaFactorBS="ttgtttttccaaaagtactttatctccggcctgacggtaggg ggagtcaaaggttaatgaaggaggaaacgtgtgatgaaaaaagcgcgaatgattgtag a" /listShort="abfA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2460425) /Source="Nicolas_upshifts" /id="U2224" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.017982017982018" /xcortree=1474 /SigmaFactorBS="ttgtttttccaaaagtactttatctccggcctgacggtaggg ggagtcaaaggttaatgaaggaggaaacgtgtgatgaaaaaagcgcgaatgattgtag a" /listShort="abfA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2460429..2461274) /gene="araQ" /locus_tag="BSU_28730" /old_locus_tag="BSU28730" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arabinose/arabinan permease" /protein_id="NP_390751.2" /db_xref="EnsemblGenomes-Gn:BSU28730" /db_xref="EnsemblGenomes-Tr:CAB14833" /db_xref="GOA:P94530" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11912" /db_xref="UniProtKB/Swiss-Prot:P94530" /translation="MLRHSPQFSVYRIALTLFFMMLSLLYLFPIFCLLLGSLKPSSEL LRVGLNLDIDPKVMSFDNYTFLFNGGSIYFKWFFNSLVLGLFTTVLTLFFSSMIGYGL AVYDFKGRNIIFVLVLIIMMVPLEVMMLPLFKLTVGLHLIDSYTGVILPFIVSPVAVF FFRQYALGLPRDLLDSARMDGCTEFGIFFRIMAPLMKPAFGAMIILQSLNSWNNFLWP LIVLRSKEMFTLPIGLSSLLSPYGNNYDMLISGSVFAILPVIIIFLFFQKYFISGLTV GGVKG*" /label="araQ CDS" gene complement(2460429..2461274) /gene="araQ" /locus_tag="BSU_28730" /old_locus_tag="BSU28730" /label="araQ gene" CDS complement(2461275..2462216) /gene="araP" /locus_tag="BSU_28740" /old_locus_tag="BSU28740" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arabinose/arabinan permease" /protein_id="NP_390752.1" /db_xref="EnsemblGenomes-Gn:BSU28740" /db_xref="EnsemblGenomes-Tr:CAB14834" /db_xref="GOA:P94529" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11911" /db_xref="UniProtKB/Swiss-Prot:P94529" /translation="MKPVKTGTVHPVPSAAKQSGWRDLFYSKKAAPYLFTAPFVLSFL VFFLYPIISVFIMSFQRILPGEVSFVGLSNYTALNNPTFYTALWNTLEYTFWTLIVLI PVPLLLAIFLNSKLVKFRNIFKSALFIPALTSTIVAGIIFRLIFGEMETSLANSILLK LGFSPQNWMNNEHTGMFLMVLLASWRWMGINILYFLAGLQNVPKELYEAADIDGANTM KKFLHITLPFLKPVTVYVLTISIIGGFRMFEESYVLWQNNSPGNIGLTLVGYLYQQGL AYNEMGYGAAIGIVLLIVILVVSLISLKLSGSFKGEG*" /label="araP CDS" gene complement(2461275..2462216) /gene="araP" /locus_tag="BSU_28740" /old_locus_tag="BSU28740" /label="araP gene" CDS complement(2462252..2463553) /gene="araN" /locus_tag="BSU_28750" /old_locus_tag="BSU28750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="sugar-binding lipoprotein" /protein_id="NP_390753.2" /db_xref="EnsemblGenomes-Gn:BSU28750" /db_xref="EnsemblGenomes-Tr:CAB14835" /db_xref="GOA:P94528" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG11910" /db_xref="UniProtKB/Swiss-Prot:P94528" /translation="MKKMTVCFLVLMMLLTLVIAGCSAEKSSGKSGETELTFWTFNGL HEQFYVEMVKEWNKKYPDRKIKLNTVVYPYGQMHDNLSISLIAGEGVPDIADVELARF SNFLKGSDIPLADLTPLIEKDRDKFVEARLTLYSKNGKLYGLDTHVGTTVMFYNMDVM KKAGVNPDDIKTWDDYHKAGQKVRKVTGKPMGTVETNDSATFLSMISQQNSGYFDKNG KLILNNDTNVKTLQYLKDMINDKTMIPAPGGGHHSEEYYGFMNQGGAASVLMPIWYMG RFIDYMPDLKGKIAIRPLPAWKEGGDRSAGLGGTATVVPKQSKHVELAKEFLAFAKGS EEGNKKLWSVLGFDPLRWDVWSSKELKEKNKYTDYFQNGTGIFSVLLDIKDEINPIYL HEDFAKASDLVNRSVLFDALKSQQKTPKQALDRAAGELKQK*" /label="araN CDS" gene complement(2462252..2463553) /gene="araN" /locus_tag="BSU_28750" /old_locus_tag="BSU28750" /label="araN gene" CDS complement(2463584..2464768) /gene="egsA" /locus_tag="BSU_28760" /old_locus_tag="BSU28760" /EC_number="1.1.1.261" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9084180, 9973362, 10417639, 11418559, 14973026, 18558723, 22720735, 27774041" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9084180, 9973362, 10417639, 11418559, 14973026, 18558723, 22720735, 27774041; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sn-glycerol-1-phosphate dehydrogenase [NAD+] (catabolic)" /protein_id="NP_390754.1" /db_xref="EnsemblGenomes-Gn:BSU28760" /db_xref="EnsemblGenomes-Tr:CAB14836" /db_xref="GOA:P94527" /db_xref="InterPro:IPR023003" /db_xref="InterPro:IPR032837" /db_xref="SubtiList:BG11909" /db_xref="UniProtKB/Swiss-Prot:P94527" /translation="MNRIAADVQRAFENAGEKTLPIKVEEIVLGKQAADSLLDYVKRK NNQHIVLVCDANTHRIAGIDLENRLNQEGFQAECLIIPENEAGDVTADERSLIHVLIH TKQPTDVMIAVGSGTIHDIVRFAAFQRDLPFISYPTAPSVDGFTSAGAPIILYGTKTT IQTKAPSALFADLDLLKAAPQSMVAAGFGDMLGKITSLADWEISRHLAGEPYSPAGAK IVQEALAACIEHTEDIAMKTETGIRVLMESLLVSGLVMLALDHSRPASGGEHHISHWI EMELMEKKRPQILHGAKVGCAAVLLTDTYRKLAQDDGLNEFSPSRREAIQSAYQTLPR GEVLADWLRSAGGPAYFDEIGVGQDSVKNAFRHAHTLRDRCTGLRIINENKTLINHGL YE*" /label="egsA CDS" gene complement(2463584..2464768) /gene="egsA" /locus_tag="BSU_28760" /old_locus_tag="BSU28760" /label="egsA gene" CDS complement(2464765..2465583) /gene="araL" /locus_tag="BSU_28770" /old_locus_tag="BSU28770" /EC_number="3.1.3.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 14973026, 21575135, 22720735, 25848029" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 14973026, 21575135, 22720735, 25848029; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glycolytic and pentose phosphate intermediates phosphatase" /protein_id="NP_390755.1" /db_xref="EnsemblGenomes-Gn:BSU28770" /db_xref="EnsemblGenomes-Tr:CAB14837" /db_xref="GOA:P94526" /db_xref="InterPro:IPR006357" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11908" /db_xref="UniProtKB/Swiss-Prot:P94526" /translation="MRIMASHDTPVSPAGILIDLDGTVFRGNELIEGAREAIKTLRRM GKKIVFLSNRGNISRAMCRKKLLGAGIETDVNDIVLSSSVTAAFLKKHYRFSKVWVLG EQGLVDELRLAGVQNASEPKEADWLVISLHETLTYDDLNQAFQAAAGGARIIATNKDR SFPNEDGNAIDVAGMIGAIETSAQAKTELVVGKPSWLMAEAACTAMGLSAHECMIIGD SIESDIAMGKLYGMKSALVLTGSAKQGEQRLYTPDYVLDSIKDVTKLAEEGILI*" /label="araL CDS" gene complement(2464765..2465583) /gene="araL" /locus_tag="BSU_28770" /old_locus_tag="BSU28770" /label="araL gene" CDS complement(2465561..2466250) /gene="araD" /locus_tag="BSU_28780" /old_locus_tag="BSU28780" /EC_number="5.1.3.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10417639, 11418559, 11732895, 14973026, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-ribulose-5-phosphate 4-epimerase" /protein_id="NP_390756.1" /db_xref="EnsemblGenomes-Gn:BSU28780" /db_xref="EnsemblGenomes-Tr:CAB14838" /db_xref="GOA:P94525" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR004661" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG11906" /db_xref="UniProtKB/Swiss-Prot:P94525" /translation="MLETLKKEVLAANLKLQEHQLVTFTWGNVSGIDREKERIVIKPS GVEYSDLTADDLVVLNLDGEVVEGSLKPSSDTPTHVYLYKAFPNIGGIVHTHSQWATS WAQSGRDIPPLGTTHADYFDSAIPCTREMYDEEIIHDYELNTGKVIAETFQHHNYEQV PGVLVNNHGPFCWGTDALNAIHNAVVLETVAEMAYHSIMLNKDVTPINTVLHEKHFYR KHGANAYYGQS*" /label="araD CDS" gene complement(2465561..2466250) /gene="araD" /locus_tag="BSU_28780" /old_locus_tag="BSU28780" /label="araD gene" CDS complement(2466267..2467949) /gene="araB" /locus_tag="BSU_28790" /old_locus_tag="BSU28790" /EC_number="2.7.1.16" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 173711, 4910050, 10417639, 11418559, 14973026, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-ribulokinase" /protein_id="NP_390757.1" /db_xref="EnsemblGenomes-Gn:BSU28790" /db_xref="EnsemblGenomes-Tr:CAB14839" /db_xref="GOA:P94524" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR005929" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG11905" /db_xref="UniProtKB/Swiss-Prot:P94524" /translation="MAYTIGVDFGTLSGRAVLVHVQTGEELAAAVKEYRHAVIDTVLP KTGQKLPRDWALQHPADYLEVLETTIPSLLEQTGVDPKDIIGIGIDFTACTILPIDSS GQPLCMLPEYEEEPHSYVKLWKHHAAQKHADRLNQIAEEEGEAFLQRYGGKISSEWMI PKVMQIAEEAPHIYEAADRIIEAADWIVYQLCGSLKRSNCTAGYKAMWSEKAGYPSDD FFEKLNPSMKTITKDKLSGSIHSVGEKAGSLTEKMAKLTGLLPGTAVAVANVDAHVSV PAVGITEPGKMLMIMGTSTCHVLLGEEVHIVPGMCGVVDNGILPGYAGYEAGQSCVGD HFDWFVKTCVPPAYQEEAKEKNIGVHELLSEKANHQAPGESGLLALDWWNGNRSTLVD ADLTGMLLGMTLLTKPEEIYRALVEATAYGTRMIIETFKESGVPIEELFAAGGIAEKN PFVMQIYADVTNMDIKISGSPQAPALGSAIFGALAAGKEKGGYDDIKKAAANMGKLKD ITYTPNAENAAVYEKLYAEYKELVHYFGKENHVMKRLKTIKNLQFSSAAKKN*" /label="araB CDS" gene complement(2466267..2467949) /gene="araB" /locus_tag="BSU_28790" /old_locus_tag="BSU28790" /label="araB gene" CDS complement(2467963..2469453) /gene="araA" /locus_tag="BSU_28800" /old_locus_tag="BSU28800" /EC_number="5.3.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 10669396, 11418559, 14973026, 18263741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 10669396, 11418559, 14973026, 18263741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-arabinose isomerase" /protein_id="NP_390758.2" /db_xref="EnsemblGenomes-Gn:BSU28800" /db_xref="EnsemblGenomes-Tr:CAB14840" /db_xref="GOA:P94523" /db_xref="InterPro:IPR003762" /db_xref="InterPro:IPR004216" /db_xref="InterPro:IPR009015" /db_xref="InterPro:IPR024664" /db_xref="SubtiList:BG11904" /db_xref="UniProtKB/Swiss-Prot:P94523" /translation="MLQTKDYEFWFVTGSQHLYGEETLELVDQHAKSICEGLSGISSR YKITHKPVVTSPETIRELLREAEYSETCAGIITWMHTFSPAKMWIEGLSSYQKPLMHL HTQYNRDIPWGTIDMDFMNSNQSAHGDREYGYINSRMGLSRKVIAGYWDDEEVKKEMS QWMDTAAALNESRHIKVARFGDNMRHVAVTDGDKVGAHIQFGWQVDGYGIGDLVEVMD RITDDEVDTLYAEYDRLYVISEETKRDEAKVASIKEQAKIELGLTAFLEQGGYTAFTT SFEVLHGMKQLPGLAVQRLMEKGYGFAGEGDWKTAALVRMMKIMAKGKRTSFMEDYTY HFEPGNEMILGSHMLEVCPTVALDQPKIEVHSLSIGGKEDPARLVFNGISGSAIQASI VDIGGRFRLVLNEVNGQEIEKDMPNLPVARVLWKPEPSLKTAAEAWILAGGAHHTCLS YELTAEQMLDWAEMAGIESVLISRDTTIHKLKHELKWNEALYRLQK*" /label="araA CDS" gene complement(2467963..2469453) /gene="araA" /locus_tag="BSU_28800" /old_locus_tag="BSU28800" /label="araA gene" promotor_-10 complement(2469546..2469565) /Source="Nicolas_upshift_promotors" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2469553) /Source="Nicolas_upshifts" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2469555..2469630) /Source="Nicolas_S_feature" /locus_tag="new_2948977_2949052_c" /HighExp="M9-stat, T1.30H, T2.0H, T2.30H, T3.0H, T4.0H, T3.30H, T1.0H, BC, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1086" promotor_-35 complement(2469580..2469587) /Source="Nicolas_upshift_promotors" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2469631..2470602) /gene="abnA" /locus_tag="BSU_28810" /old_locus_tag="BSU28810" /EC_number="3.2.1.99" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 15556708, 17827291, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 15556708, 17827291, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinan-endo-1,5-alpha-L-arabinase" /protein_id="NP_390759.2" /db_xref="EnsemblGenomes-Gn:BSU28810" /db_xref="EnsemblGenomes-Tr:CAB14841" /db_xref="GOA:P94522" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR016840" /db_xref="InterPro:IPR023296" /db_xref="PDB:1UV4" /db_xref="SubtiList:BG11901" /db_xref="UniProtKB/Swiss-Prot:P94522" /translation="MKKKKTWKRFLHFSSAALAAGLIFTSAAPAEAAFWGASNELLHD PTMIKEGSSWYALGTGLTEERGLRVLKSSDAKNWTVQKSIFTTPLSWWSNYVPNYGQN QWAPDIQYYNGKYWLYYSVSSFGSNTSAIGLASSTSISSGGWKDEGLVIRSTSSNNYN AIDPELTFDKDGNPWLAFGSFWSGIKLTKLDKSTMKPTGSLYSIAARPNNGGALEAPT LTYQNGYYYLMVSFDKCCDGVNSTYKIAYGRSKSITGPYLDKSGKSMLEGGGTILDSG NDQWKGPGGQDIVNGNILVRHAYDANDNGIPKLLINDLNWSSGWPSY*" /label="abnA CDS" gene complement(2469631..2470602) /gene="abnA" /locus_tag="BSU_28810" /old_locus_tag="BSU28810" /label="abnA gene" S_feature complement(2470603..2470731) /Source="Nicolas_S_feature" /locus_tag="new_2950025_2950153_c" /HighExp="M9-stat, BC, T2.0H, T2.30H, T3.0H, S8, T1.30H, T3.30H, M0t90, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1087" promotor_-10 complement(2470716..2470735) /Source="Nicolas_upshift_promotors" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="promotor_-10" upshifts complement(2470731) /Source="Nicolas_upshifts" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="upshifts" promotor_-35 complement(2470750..2470753) /Source="Nicolas_upshift_promotors" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="promotor_-35" CDS complement(2470799..2471884) /gene="frvX" /locus_tag="BSU_28820" /old_locus_tag="BSU28820" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15375159, 16021622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative fructose-lysine aminopeptidase" /protein_id="NP_390760.1" /db_xref="EnsemblGenomes-Gn:BSU28820" /db_xref="EnsemblGenomes-Tr:CAB14842" /db_xref="GOA:P94521" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="PDB:1VHE" /db_xref="SubtiList:BG12317" /db_xref="UniProtKB/Swiss-Prot:P94521" /translation="MAKLDETLTMLKDLTDAKGIPGNEREVRQVMKSYIEPFADEVTT DRLGSLIAKKTGAENGPKIMIAGHLDEVGFMVTQITDKGFIRFQTVGGWWAQVMLAQR VTIVTKKGEITGVIGSKPPHILSPEARKKSVEIKDMFIDIGASSREEALEWGVLPGDM IVPHFEFTVMNNEKFLLAKAWDNRIGCAIAIDVLRNLQNTDHPNIVYGVGTVQEEVGL RGAKTAAHTIQPDIAFGVDVGIAGDTPGISEKEAQSKMGKGPQIIVYDASMVSHKGLR DAVVATAEEAGIPYQFDAIAGGGTDSGAIHLTANGVPALSITIATRYIHTHAAMLHRD DYENAVKLITEVIKKLDRKTVDEITYQ*" /label="frvX CDS" gene complement(2470799..2471884) /gene="frvX" /locus_tag="BSU_28820" /old_locus_tag="BSU28820" /label="frvX gene" downshifts complement(2470813) /Source="Nicolas_upshifts" /id="D1473" /incds=0 /nref=233 /ntot=262 /MaxReadThrough="3.55686" /MaxDrop="6.91328" /score="-0.475558157" /energy="-9.9" /TU="U2227" /idTUdmin="U2227" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2471910..2471929) /Source="Nicolas_upshift_promotors" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="promotor_-10" upshifts complement(2471933) /Source="Nicolas_upshifts" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="upshifts" promotor_-35 complement(2471944..2471951) /Source="Nicolas_upshift_promotors" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="promotor_-35" promotor_-35 2472002..2472011 /Source="Nicolas_upshift_promotors" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2472017 /Source="Nicolas_upshifts" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2472023..2472038 /Source="Nicolas_upshift_promotors" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2472068..2472460 /gene="ysdB" /locus_tag="BSU_28830" /old_locus_tag="BSU28830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10960106, 23155385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390761.1" /db_xref="EnsemblGenomes-Gn:BSU28830" /db_xref="EnsemblGenomes-Tr:CAB14843" /db_xref="GOA:P94520" /db_xref="SubtiList:BG12316" /db_xref="UniProtKB/Swiss-Prot:P94520" /translation="MFVMVLRIILLALFAYCIYAVVKYVANPKRRLKLAQSKEHFYII DEQNNTRKNFQLTYKGVLFEGEKHIPSKDHPLFIHTIFVWTESPEKLKHFSAKDFENI EEKVLERYPNCKIDWDQPIKLAKKAEER*" /label="ysdB CDS" gene 2472068..2472460 /gene="ysdB" /locus_tag="BSU_28830" /old_locus_tag="BSU28830" /label="ysdB gene" downshifts 2472431 /Source="Nicolas_upshifts" /id="D1474" /incds=0 /nref=86 /ntot=229 /MaxReadThrough="5.09744" /MaxDrop="4.57118" /score="13.4996084" /energy="-15.8" /TU="U2228" /idTUdmin="U2228" /TUdmin="-2112" /isTUend="FALSE" /label="downshifts" S_feature 2472476..2472782 /Source="Nicolas_S_feature" /locus_tag="new_2951898_2952204" /HighExp="Etha, M9-stat, T0.30H, T1.30H, T1.0H, T2.0H, T2.30H, S8, T3.30H, Salt" /AntisenseName="ysdA" /AntisenseCor="-0.31305612685159701" /AntisenseRegPval="-6.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1088" CDS complement(2472476..2472745) /gene="ysdA" /locus_tag="BSU_28840" /old_locus_tag="BSU28840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17289755; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane component" /protein_id="NP_390762.1" /db_xref="EnsemblGenomes-Gn:BSU28840" /db_xref="EnsemblGenomes-Tr:CAB14844" /db_xref="GOA:P94519" /db_xref="InterPro:IPR010718" /db_xref="SubtiList:BG12315" /db_xref="UniProtKB/Swiss-Prot:P94519" /translation="MIIAAYLVLINLCGFWVMGIDKRKAQQHKWRISEDRLWLIAIVF GALGVWLGMQTFRHKTKHASFKYGVPLLLVIEAILIAIYYSPFDL*" /label="ysdA CDS" gene complement(2472476..2472745) /gene="ysdA" /locus_tag="BSU_28840" /old_locus_tag="BSU28840" /label="ysdA gene" downshifts complement(2472492) /Source="Nicolas_upshifts" /id="D1475" /incds=0 /nref=6 /ntot=206 /MaxReadThrough="2.53274" /MaxDrop="3.80421" /score="20.1281719" /energy="-14" /TU="U2229" /idTUdmin="U2230" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" downshifts complement(2472661) /Source="Nicolas_upshifts" /id="D1476" /incds=1 /nref=1 /ntot=37 /MaxReadThrough="4.90568" /MaxDrop="2.19601" /score="25.5196116" /energy="-14.1" /TU="U2229,U2230" /idTUdmin="U2230" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts 2472739 /Source="Nicolas_upshifts" /id="D1477" /incds=0 /nref=8 /ntot=135 /MaxReadThrough="4.08794" /MaxDrop="3.37039" /score="13.4996084" /energy="-15.8" /TU="U2228" /idTUdmin="U2228" /TUdmin="-1804" /isTUend="FALSE" /label="downshifts" CDS complement(2472802..2473161) /gene="rplT" /locus_tag="BSU_28850" /old_locus_tag="BSU28850" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12682299, 17289755, 21843271, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17289755, 21843271, 23611891; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L20" /protein_id="NP_390763.1" /db_xref="EnsemblGenomes-Gn:BSU28850" /db_xref="EnsemblGenomes-Tr:CAB14845" /db_xref="GOA:P55873" /db_xref="InterPro:IPR005813" /db_xref="InterPro:IPR035566" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11971" /db_xref="UniProtKB/Swiss-Prot:P55873" /translation="MPRVKGGTVTRKRRKKVLKLAKGYFGSKHTLYKVANQQVMKSGN YAFRDRRQKKRDFRKLWITRINAAARMNGLSYSRLMHGLKLSGIEVNRKMLADLAVND LTAFNQLADAAKAQLNK*" /label="rplT CDS" gene complement(2472802..2473161) /gene="rplT" /locus_tag="BSU_28850" /old_locus_tag="BSU28850" /label="rplT gene" downshifts complement(2472815) /Source="Nicolas_upshifts" /id="D1478" /incds=0 /nref=260 /ntot=268 /MaxReadThrough="5.94351" /MaxDrop="6.27682" /score="25.5196116" /energy="-14.1" /TU="U2229,U2230" /idTUdmin="U2230" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" CDS complement(2473193..2473393) /gene="rpmI" /locus_tag="BSU_28860" /old_locus_tag="BSU28860" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 12682299, 17289755, 21843271, 23002217, 23611891, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 12682299, 17289755, 21843271, 23002217, 23611891, 24335279; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L35" /protein_id="NP_390764.1" /db_xref="EnsemblGenomes-Gn:BSU28860" /db_xref="EnsemblGenomes-Tr:CAB14846" /db_xref="GOA:P55874" /db_xref="InterPro:IPR001706" /db_xref="InterPro:IPR018265" /db_xref="InterPro:IPR021137" /db_xref="InterPro:IPR037229" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11972" /db_xref="UniProtKB/Swiss-Prot:P55874" /translation="MPKMKTHRGSAKRFKKTGSGKLKRSHAYTSHLFANKSQKQKRKL RKSAVVSAGDFKRIKQMLANIK*" /label="rpmI CDS" gene complement(2473193..2473393) /gene="rpmI" /locus_tag="BSU_28860" /old_locus_tag="BSU28860" /label="rpmI gene" CDS complement(2473406..2473927) /gene="infC" /locus_tag="BSU_28870" /old_locus_tag="BSU28870" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17289755, 21843271, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17289755, 21843271, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-3" /protein_id="NP_390765.1" /db_xref="EnsemblGenomes-Gn:BSU28870" /db_xref="EnsemblGenomes-Tr:CAB14847" /db_xref="GOA:P55872" /db_xref="InterPro:IPR001288" /db_xref="InterPro:IPR019813" /db_xref="InterPro:IPR019814" /db_xref="InterPro:IPR019815" /db_xref="InterPro:IPR036787" /db_xref="InterPro:IPR036788" /db_xref="SubtiList:BG11944" /db_xref="UniProtKB/Swiss-Prot:P55872" /translation="MISKDQLVNEGIRAREVRLIGQNGDQLGIKSRQEALEIAGRANL DLVLVAANAKPPVCRIMDYGKFRFEQQKKEKEARKNQKIINLKEVRLSPTIDEHDFNT KLRNAIKFLEKGDKVKASIRFKGRAITHKEIGQRVLDRFSEACAEVATVETKPKMDGR SMFLMLAPKNEKQ*" /label="infC CDS" gene complement(2473406..2473927) /gene="infC" /locus_tag="BSU_28870" /old_locus_tag="BSU28870" /label="infC gene" misc_RNA complement(2473989..2474128) /locus_tag="BSU_misc_RNA_47" /product="mRNA L20_leader attenuator sequence" /experiment="publication(s) with functional evidences, PMID:17289755, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17289755, 23611891" /label="mRNA L20 leader attenuator sequence" gene complement(2473989..2474128) /locus_tag="BSU_misc_RNA_47" /label="gene" promotor_-10 complement(2474125..2474144) /Source="Nicolas_upshift_promotors" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2474135) /Source="Nicolas_upshifts" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2474137..2474201) /Source="Nicolas_S_feature" /locus_tag="new_2953559_2953623_c" /HighExp="Paraq, G180, G150, G135, H2O2, LPh, C30, Oxctl, LBGexp, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1089" promotor_-35 complement(2474158..2474165) /Source="Nicolas_upshift_promotors" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2474183..2474202) /Source="Nicolas_upshift_promotors" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2474201) /Source="Nicolas_upshifts" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2474218..2474222) /Source="Nicolas_upshift_promotors" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2474320..2474327 /Source="Nicolas_upshift_promotors" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2474341..2474359 /Source="Nicolas_upshift_promotors" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2474341 /Source="Nicolas_upshifts" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="upshifts" CDS 2474373..2475038 /gene="yscB" /locus_tag="BSU_28890" /old_locus_tag="BSU28890" /function="14: Cell envelope" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390767.2" /db_xref="EnsemblGenomes-Gn:BSU28890" /db_xref="EnsemblGenomes-Tr:CAB14849" /db_xref="SubtiList:BG12314" /db_xref="UniProtKB/Swiss-Prot:P94517" /translation="MNKLIQLALFFTLMLTGCSNSSTSSESKVETTVKTTAAFPQKEL EKELKKLKPVSLDMKFESPLATELGKRKAKEEAEKQRQIAAEKKLEKEREAKRKKQQE EKAERQRLAEQQAAERQRLAEAERQAELERQRQAAIQKEQKANAEKKRQSQAQRQQTE APSSNSQDPPSSSSQTDKTIQQPASELPDDDGYGYEERKKWHDDQVEWGIKQGYIDPE DAP*" /label="yscB CDS" gene 2474373..2475038 /gene="yscB" /locus_tag="BSU_28890" /old_locus_tag="BSU28890" /label="yscB gene" downshifts 2475016 /Source="Nicolas_upshifts" /id="D1479" /incds=0 /nref=27 /ntot=178 /MaxReadThrough="2.51181" /MaxDrop="3.43861" /score="13.4996084" /energy="-15.8" /TU="NA" /idTUdmin="U2231" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2475070..2475765) /gene="pftB" /locus_tag="BSU_28900" /old_locus_tag="BSU28900" /function="16.5: Explore" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15126464, 15849754, 16850406, 17452642, 26060272, 26406329, 28974613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15126464, 15849754, 16850406, 17452642, 26060272, 26406329, 28974613; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pyruvate import system subunit B" /protein_id="NP_390768.1" /db_xref="EnsemblGenomes-Gn:BSU28900" /db_xref="EnsemblGenomes-Tr:CAB14850" /db_xref="GOA:P94516" /db_xref="InterPro:IPR007300" /db_xref="InterPro:IPR024891" /db_xref="SubtiList:BG12312" /db_xref="UniProtKB/Swiss-Prot:P94516" /translation="MESTMSPYFGIVVSLAAFGIGTFLFKKTKGFFLFTPLFVAMVLG IAFLKIGGFSYADYNNGGEIIKFFLEPATIAFAIPLYKQRDKLKKYWWQIMASIIAGS ICSVTIVYLLAKGIHLDSAVMKSMLPQAATTAIALPLSKGIGGISDITAFAVIFNAVI VYALGALFLKVFKVKNPISKGLALGTSGHALGVAVGIEMGEVEAAMASIAVVVVGVVT VLVIPVFVQLIGG*" /label="pftB CDS" gene complement(2475070..2475765) /gene="pftB" /locus_tag="BSU_28900" /old_locus_tag="BSU28900" /label="pftB gene" downshifts complement(2475092) /Source="Nicolas_upshifts" /id="D1480" /incds=0 /nref=19 /ntot=45 /MaxReadThrough="1.25312" /MaxDrop="6.13174" /score="49.3872074" /energy="-13.7" /TU="NA" /idTUdmin="U2232" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2475136) /Source="Nicolas_upshifts" /id="D1481" /incds=1 /nref=2 /ntot=36 /MaxReadThrough="6.79502" /MaxDrop="3.1016" /score="49.3872074" /energy="-13.7" /TU="U2232" /idTUdmin="U2232" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(2475787..2476227) /gene="pftA" /locus_tag="BSU_28910" /old_locus_tag="BSU28910" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15659658, 17452642, 26060272, 27422364, 28974613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15659658, 17452642, 26060272, 27422364, 28974613; Product type t : transporter" /codon_start=1 /transl_table=11 /product="pyruvate uptake system subunit A" /protein_id="NP_390769.1" /db_xref="EnsemblGenomes-Gn:BSU28910" /db_xref="EnsemblGenomes-Tr:CAB14851" /db_xref="GOA:P94515" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR023736" /db_xref="SubtiList:BG12311" /db_xref="UniProtKB/Swiss-Prot:P94515" /translation="MSAKKVYGFLTQAFIFAVIMLVSNMIAAIVPIPIPASVVGLVLL FLLLCLKVIKLEQVETLGTSLTSLIGFLFVPSGISVMNSLGVMQQYGLQIVLVILLAT IILLGATGLFSQLILSLSGKRKTEADMKTKTVQSPQNNNELVHH*" /label="pftA CDS" gene complement(2475787..2476227) /gene="pftA" /locus_tag="BSU_28910" /old_locus_tag="BSU28910" /label="pftA gene" promotor_-10 complement(2476249..2476268) /Source="Nicolas_upshift_promotors" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2476268) /Source="Nicolas_upshifts" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2476284..2476287) /Source="Nicolas_upshift_promotors" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2476361..2477086) /gene="lytT" /locus_tag="BSU_28920" /old_locus_tag="BSU28920" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [LytS]" /protein_id="NP_390770.1" /db_xref="EnsemblGenomes-Gn:BSU28920" /db_xref="EnsemblGenomes-Tr:CAB14852" /db_xref="GOA:P94514" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR007492" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11953" /db_xref="UniProtKB/Swiss-Prot:P94514" /translation="MLRVLIVDDEMLARDELAYLLKRTNDEMEINEAENIESAFDQMM DQKPDLLFLDVDLSGENGFDIAKRLKKMKHPPAIVFATAYDQYALKAFEVDALDYLTK PFDEERIQQTLKKYKKVNRDIVETEQNSHAGQHKLALSVGESIVIVDTKDIIYAGTED GHVNVKTFDHSYTVSDTLVVIEKKLPDSDFIRVHRSFVVNTEYIKEIQPWFNSTYNLI MKDGSKIPVSRTYAKELKKLLHI*" /label="lytT CDS" gene complement(2476361..2477086) /gene="lytT" /locus_tag="BSU_28920" /old_locus_tag="BSU28920" /label="lytT gene" downshifts complement(2476390) /Source="Nicolas_upshifts" /id="D1482" /incds=0 /nref=231 /ntot=256 /MaxReadThrough="-0.0173499999999995" /MaxDrop="6.64673" /score="-8.47161605" /energy="-8.9" /TU="NA" /idTUdmin="U2232" /TUdmin="-1298" /isTUend="FALSE" /label="downshifts" CDS complement(2477064..2478845) /gene="lytS" /locus_tag="BSU_28930" /old_locus_tag="BSU28930" /function="16.3: Control" /function="16.13: Shape" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LytT]" /protein_id="NP_390771.1" /db_xref="EnsemblGenomes-Gn:BSU28930" /db_xref="EnsemblGenomes-Tr:CAB14853" /db_xref="GOA:P94513" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR011620" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11952" /db_xref="UniProtKB/Swiss-Prot:P94513" /translation="MIHLMIMMLERVGIIVILGFILAHTKLFRQALQNQDGYKGKAIL ISIFSLFSIISNYTGIEIQRNMIVNNDWVFTIDPSGSIANTRILGVEIGGLLGGPFVG AGIGILAGLHRFSLGGSTALSCAVSSILAGVLAGLIGRYFTKRYRMPTPRIAALVGIG MESLQMIIILLMAKPFSDAWELVSMIGIPMILINGTGSFIFLSIIQAIIRKEEQARAL ETHRVLTIADQTLPFFRQGLNENSCKSVAAIIHKLTGTDAVSLTDKEKILAHVGAGMD HHIPSKSLITGLSKKVIKTGHIMKAISQEEIECTHAECPLHAAIVLPLTSNGNTIGTL KMYFKSPAGLSQVEEELAEGLAMLFSTQLELGEAELQSKLLKDAEIKALQAQVNPHFL FNAINTISALCRTDVEKTRKLLLQLSVYFRSNLQGARQLLIPLSKELNHLNAYLSLEQ ARFPGKYKIELNIDSRLEQIEIPPFVLQVLVENALRHAFPKKQDICKVTVCVLSDDAS VYMKVADNGRGIPPDVLPELGKKPFPSKEGTGTALYNLNQRLIGLFGQQAALHISSEV HKGTEVSFQVPMQQMKEGEEHAQGVNS*" /label="lytS CDS" gene complement(2477064..2478845) /gene="lytS" /locus_tag="BSU_28930" /old_locus_tag="BSU28930" /label="lytS gene" promotor_-35 2478929..2478932 /Source="Nicolas_upshift_promotors" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2478941..2478960) /Source="Nicolas_upshift_promotors" /id="U2233" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.999000999001" /xcortree=3026 /SigmaFactorBS="tctcctctgcttcagattcaaatctttctgccaaaaggctca tgttTTATTTTACAATAGATAAAAgccttgtgaaatatgttttcagacgattttaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2478946) /Source="Nicolas_upshifts" /id="U2233" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.999000999001" /xcortree=3026 /SigmaFactorBS="tctcctctgcttcagattcaaatctttctgccaaaaggctca tgttTTATTTTACAATAGATAAAAgccttgtgaaatatgttttcagacgattttaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2478947..2478966 /Source="Nicolas_upshift_promotors" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2478954 /Source="Nicolas_upshifts" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="upshifts" CDS 2479012..2479794 /gene="ysaA" /locus_tag="BSU_28940" /old_locus_tag="BSU28940" /EC_number="3.1.3.-" /experiment="publication(s) with functional evidences, PMID:15479782, 24123841, 25848029, 27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15479782, 24123841, 25848029, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphatase" /protein_id="NP_390772.2" /db_xref="EnsemblGenomes-Gn:BSU28940" /db_xref="EnsemblGenomes-Tr:CAB14854" /db_xref="GOA:P94512" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG12310" /db_xref="UniProtKB/Swiss-Prot:P94512" /translation="MKAVFFDLDDTLLWDEKSVRTTFAETCLQAEKKYGLAPEEFEAA VREAARELYMSYETYPYTVMIGINPFEGLWSNFSEPISEGFQKLNKIVPEYRRNAWTN GLKALGIDDPAYGEYLGEFFAAERRKRPFVYDETFAVLDQLKGKYELLLLTNGDPSLQ KEKLAGVPELAPYFNEIVISGAFGKGKPDVSIFEHCLKLMNIEKDDAIMVGDNLNTDI LGASRAGIKTVWINRTDKKNETDVKPDYIISSLHDLFPILEK*" /label="ysaA CDS" gene 2479012..2479794 /gene="ysaA" /locus_tag="BSU_28940" /old_locus_tag="BSU28940" /label="ysaA gene" downshifts 2479778 /Source="Nicolas_upshifts" /id="D1483" /incds=0 /nref=36 /ntot=265 /MaxReadThrough="1.0046" /MaxDrop="6.73727" /score="35.9560361" /energy="-13.8" /TU="NA" /idTUdmin="U2234" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" downshifts complement(2479828) /Source="Nicolas_upshifts" /id="D1484" /incds=0 /nref=89 /ntot=246 /MaxReadThrough="1.13716" /MaxDrop="6.01766" /score="35.534455" /energy="-13.8" /TU="NA" /idTUdmin="U2235" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(2479835..2481766) /gene="thrS" /locus_tag="BSU_28950" /old_locus_tag="BSU28950" /EC_number="6.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8692931, 9826762, 10632708, 15831787, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8692931, 9826762, 10632708, 15831787, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonyl-tRNA synthetase" /protein_id="NP_390773.1" /db_xref="EnsemblGenomes-Gn:BSU28950" /db_xref="EnsemblGenomes-Tr:CAB14855" /db_xref="GOA:P18255" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002320" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR033728" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG10362" /db_xref="UniProtKB/Swiss-Prot:P18255" /translation="MSDMVKITFPDGAVKEFAKGTTTEDIAASISPGLKKKSLAGKLN GKEIDLRTPINEDGTVEIITEGSEEGLQIMRHSAAHLLAQAIKRIYKDVKFGVGPVIE NGFYYDVEMDEAITPEDLPKIEKEMKKIVNANLPIVRKEVSREEAKARFAEIGDDLKL ELLDAIPEGETVSIYEQGEFFDLCRGVHVPSTGKIKEFKLLSLAGAYWRGDSKNQMLQ RVYGTAFFKKADLEEHLRMLEEAKERDHRKLGKELKLFANSQKVGQGLPLWLPKGATI RRVIERYIVDKEISLGYEHVYTPVLGSKELYETSGHWDHYQEGMFPPMEMDNETLVLR PMNCPHHMMIYKQDIHSYRELPIRIAELGTMHRYEMSGALSGLQRVRGMTLNDAHIFV RPDQIKDEFIRTVRLIQDVYEDFGLSDYTFRLSYRDPEDTEKYFDDDEMWNKAQSMLK EAMDEIGHDYYEAEGEAAFYGPKLDVQVKTAIGKEETLSTVQLDFLLPERFDLTYIGE DGKQHRPVVIHRGVVSTMERFVAFLIEEHKGALPTWLAPVQFQVIPVSPAVHLDYAKK VQERLQCEGLRVEVDSRDEKIGYKIREAQMQKIPYMLVVGDQEAENGAVNVRKYGEQN SETISLDEFVKKAVAEAKK*" /label="thrS CDS" gene complement(2479835..2481766) /gene="thrS" /locus_tag="BSU_28950" /old_locus_tag="BSU28950" /label="thrS gene" misc_RNA complement(2481810..2482057) /gene="tboT" /locus_tag="BSU_misc_RNA_48" /product="T-box riboswitch specific of threonine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:9098041, 9826762, 1317842, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098041, 9826762, 1317842, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboT RNA" gene complement(2481810..2482057) /gene="tboT" /locus_tag="BSU_misc_RNA_48" /label="tboT gene" promotor_-10 complement(2481813..2481822) /Source="Nicolas_upshift_promotors" /id="U2235" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.0969030969030969" /xcortree=1774 /SigmaFactorBS="gtgtattggctttgcggaaaaaagggtggaacCacgattccg tttattcaaCCTCGTCCCTttcatagggggcggggtttttatatgcaaaaaaaggagt g" /listShort="thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2481813) /Source="Nicolas_upshifts" /id="U2235" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.0969030969030969" /xcortree=1774 /SigmaFactorBS="gtgtattggctttgcggaaaaaagggtggaacCacgattccg tttattcaaCCTCGTCCCTttcatagggggcggggtttttatatgcaaaaaaaggagt g" /listShort="thrS" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2481868) /Source="Nicolas_upshifts" /id="D1485" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="6.71261" /MaxDrop="3.31801" /score="19.160794" /energy="-16.2" /TU="U2236,U2237,U2238,U2241" /idTUdmin="U2239" /TUdmin=221 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2482068..2482087) /Source="Nicolas_upshift_promotors" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2482081) /Source="Nicolas_upshifts" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2482083..2482163) /Source="Nicolas_S_feature" /locus_tag="new_2961505_2961585_c" /HighExp="S3, S4, LoTm, S5, G135, G180, LBGtran, T5.0H, G/S, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigA, SigA" /TUshortPSig="1, 1, 0.998, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1090" promotor_-35 complement(2482103..2482107) /Source="Nicolas_upshift_promotors" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2482164..2483009) /gene="ytxC" /locus_tag="BSU_28960" /old_locus_tag="BSU28960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22882546; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="sporulation protein" /protein_id="NP_390774.2" /db_xref="EnsemblGenomes-Gn:BSU28960" /db_xref="EnsemblGenomes-Tr:CAB14856" /db_xref="InterPro:IPR014199" /db_xref="SubtiList:BG10361" /db_xref="UniProtKB/Swiss-Prot:P06569" /translation="MLEIIFEDDHDAAAFLHLIQHSDDRNNIIVREGIRKIGIEKANP AFPIQRFMEPILVKFFLECKEDEHMLSLIEETYCFTDQDEQQQILQLAHSIIEGEADD LPFEPLKLSRKQSILDELQTICLEEGVFYIRSFQTFRLGSYYKQLRDITEAAIDEYKM EQEYQNFIQTLRDYVDAKQPRIKKVHIVHDGSFTLWELRYVPEREKMKYIDRRFVRDH PMYIDSHLLAPLISIAPDEVVLYTDQPEHMMARTIQNVFQERVEMLPLHAFTDAEIPV KHSEG*" /label="ytxC CDS" gene complement(2482164..2483009) /gene="ytxC" /locus_tag="BSU_28960" /old_locus_tag="BSU28960" /label="ytxC gene" promotor_-10 complement(2483029..2483047) /Source="Nicolas_upshift_promotors" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2483035) /Source="Nicolas_upshifts" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2483063..2483068) /Source="Nicolas_upshift_promotors" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2483088..2483729) /gene="ytxB" /locus_tag="BSU_28970" /old_locus_tag="BSU28970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25728272, 27190159; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative osomosensing transporter" /protein_id="NP_390775.1" /db_xref="EnsemblGenomes-Gn:BSU28970" /db_xref="EnsemblGenomes-Tr:CAB14857" /db_xref="GOA:P06568" /db_xref="InterPro:IPR015414" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG10360" /db_xref="UniProtKB/Swiss-Prot:P06568" /translation="MKRKTAVKWLAVLAGAGLLYWGNKTYLNVSPKEIRVWVLSFGVF APLMFIGISIVRPLVLFPVSVISIAGGLAFGPLLGTLYTLFGSMCASAVSFFAAGLFS AKKNGHYERLEAIQKQMEDNGFFYIFLLRILPINFDFVSYAAGLSNVKALPYFAATAV GIIPGTIALNVLGASFLAGNLPAFFMVLALYIVFISLPFIFRKKMQNLFQESN*" /label="ytxB CDS" gene complement(2483088..2483729) /gene="ytxB" /locus_tag="BSU_28970" /old_locus_tag="BSU28970" /label="ytxB gene" CDS complement(2483763..2484698) /gene="dnaI" /locus_tag="BSU_28980" /old_locus_tag="BSU28980" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 17003052, 17289076, 19255093, 19968790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17003052, 17289076, 19255093, 19968790; Product type f: factor" /codon_start=1 /transl_table=11 /product="helicase loader" /protein_id="NP_390776.1" /db_xref="EnsemblGenomes-Gn:BSU28980" /db_xref="EnsemblGenomes-Tr:CAB14858" /db_xref="GOA:P06567" /db_xref="InterPro:IPR002611" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009928" /db_xref="InterPro:IPR027417" /db_xref="PDB:2K7R" /db_xref="PDB:4M4W" /db_xref="SubtiList:BG10359" /db_xref="UniProtKB/Swiss-Prot:P06567" /translation="MEPIGRSLQGVTGRPDFQKRLEQMKEKVMKDQDVQAFLKENEEV IDQKMIEKSLNKLYEYIEQSKNCSYCSEDENCNNLLEGYHPKLVVNGRSIDIEYYECP VKRKLDQQKKQQSLMKSMYIQQDLLGATFQQVDISDPSRLAMFQHVTDFLKSYNETGK GKGLYLYGKFGVGKTFMLAAIANELAEKEYSSMIVYVPEFVRELKNSLQDQTLEEKLN MVKTTPVLMLDDIGAESMTSWVRDEVIGTVLQHRMSQQLPTFFSSNFSPDELKHHFTY SQRGEKEEVKAARLMERILYLAAPIRLDGENRRHP*" /label="dnaI CDS" gene complement(2483763..2484698) /gene="dnaI" /locus_tag="BSU_28980" /old_locus_tag="BSU28980" /label="dnaI gene" CDS complement(2484726..2486144) /gene="dnaB" /locus_tag="BSU_28990" /old_locus_tag="BSU28990" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 15186423, 16002087, 17289076, 20071750, 21097613, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15186423, 16002087, 17289076, 20071750, 21097613, 23525462; Product type f: factor" /codon_start=1 /transl_table=11 /product="helicase loading protein; replication initiationmembrane attachment protein" /protein_id="NP_390777.1" /db_xref="EnsemblGenomes-Gn:BSU28990" /db_xref="EnsemblGenomes-Tr:CAB14859" /db_xref="GOA:P07908" /db_xref="InterPro:IPR006343" /db_xref="InterPro:IPR034829" /db_xref="SubtiList:BG10358" /db_xref="UniProtKB/Swiss-Prot:P07908" /translation="MADYWKDVLPVDPYVVKSRSMLQDIDRQIITQLYQPLIGPVAFS LYMTLWGELEQNRLWGGESTHRQLMGMTQSNLKTIHQEQGKLEGIGLLKVYMKESERQ ERLFIYELLPPLRPNEFFEDGMLNVFLYNRVGKTKYQQLKQFFTHPAISEDAKDITRP FNHAFESLQPSEWKLTSDMEETVRLAEGSEYTSVGQSPSYTITEDVFDFDLFLAGLSE TMIPRKAMTQQVRDTIKKLSYLYGIDPLQMQNVVMSAIDERDVITTEALRKAASDWYQ IERNGQLPDLVEKTQPVHLREGEQPAEEDSLDGKLIALLEAISPKKLLQDIADGTEPS KADLKIIEEIMFEQKLEPGVTNVLIYYVMLKTDMKLSKNYIQKIASHWARKKVKTVRE AMKLAIEENRQYLEWAEGKTKSSKRNQKVIREEKLPDWMTEKETASDSESGQQKLHPQ DLEEQKKKMMEEMQKLKKYSAY*" /label="dnaB CDS" gene complement(2484726..2486144) /gene="dnaB" /locus_tag="BSU_28990" /old_locus_tag="BSU28990" /label="dnaB gene" promotor_-10 complement(2486173..2486192) /Source="Nicolas_upshift_promotors" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2486181) /Source="Nicolas_upshifts" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2486207..2486210) /Source="Nicolas_upshift_promotors" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2486259..2486717) /gene="nrdR" /locus_tag="BSU_29000" /old_locus_tag="BSU29000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16950922, 27920297, 28624879" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16950922, 27920297, 28624879; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of transcription of ribonucleotide reductase nrd genes and operons" /protein_id="NP_390778.1" /db_xref="EnsemblGenomes-Gn:BSU29000" /db_xref="EnsemblGenomes-Tr:CAB14860" /db_xref="GOA:Q45549" /db_xref="InterPro:IPR003796" /db_xref="InterPro:IPR005144" /db_xref="SubtiList:BG13833" /db_xref="UniProtKB/Swiss-Prot:Q45549" /translation="MKCPSCQHNGTRVLDSRPVDDGKSIRRRRECESCHYRFTTFEKV EETPLIVVKKEGVREEFSREKMLRGLIKACEKRPVSLKTLEDMCFDIEKELRNQGCSE VKSELVGEMVMDRLAKIDEVAYVRFASVYRQFKDINVFIDELKDLIKKER*" /label="nrdR CDS" gene complement(2486259..2486717) /gene="nrdR" /locus_tag="BSU_29000" /old_locus_tag="BSU29000" /label="nrdR gene" downshifts complement(2486278) /Source="Nicolas_upshifts" /id="D1486" /incds=0 /nref=14 /ntot=175 /MaxReadThrough="4.1553" /MaxDrop="3.90408" /score="12.4797073" /energy="-21.2" /TU="U2239,U2241" /idTUdmin="U2243" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" S_feature complement(2486718..2486865) /Source="Nicolas_S_feature" /locus_tag="new_2966140_2966287_c" /HighExp="dia5, dia15, Lbstat, Diami, Heat, M9-stat, M0t90, M40t90, LBGtran, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigGF, SigA" /TUshortPSig="0.998, 0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1091" promotor_-10 complement(2486856..2486875) /Source="Nicolas_upshift_promotors" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="promotor_-10" upshifts complement(2486865) /Source="Nicolas_upshifts" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="upshifts" S_feature complement(2486867..2486945) /Source="Nicolas_S_feature" /locus_tag="new_2966289_2966367_c" /HighExp="Lbstat, M40t90, Heat, M9-stat, M0t90, G180, S8, S5, T1.30H, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigA" /TUshortPSig="0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1092" promotor_-35 complement(2486890..2486893) /Source="Nicolas_upshift_promotors" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="promotor_-35" downshifts complement(2486990) /Source="Nicolas_upshifts" /id="D1487" /incds=0 /nref=204 /ntot=262 /MaxReadThrough="5.70146" /MaxDrop="5.85416" /score="12.4797073" /energy="-21.2" /TU="U2241,U2242,U2243" /idTUdmin="U2242" /TUdmin="-237" /isTUend="FALSE" /label="downshifts" CDS complement(2486991..2487371) /gene="speD" /locus_tag="BSU_29010" /old_locus_tag="BSU29010" /EC_number="4.1.1.50" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9723923, 10844697, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 10844697, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine decarboxylase" /protein_id="NP_390779.2" /db_xref="EnsemblGenomes-Gn:BSU29010" /db_xref="EnsemblGenomes-Tr:CAB14861" /db_xref="GOA:O34426" /db_xref="InterPro:IPR003826" /db_xref="InterPro:IPR016067" /db_xref="InterPro:IPR017716" /db_xref="SubtiList:BG13832" /db_xref="UniProtKB/Swiss-Prot:O34426" /translation="METMGRHVISELWGCDFDKLNDMDFIEKTFVNAALKSGAEVREV AFHKFAPQGVSGVVIISESHLTIHSFPEHGYASIDVYTCGDLDPNVAADYIAEALHAD TRENIEIPRGMGPVQIKQAQAKVL*" /label="speD CDS" gene complement(2486991..2487371) /gene="speD" /locus_tag="BSU_29010" /old_locus_tag="BSU29010" /label="speD gene" S_feature complement(2487372..2487526) /Source="Nicolas_S_feature" /locus_tag="new_2966794_2966948_c" /HighExp="Lbstat, M40t90, M9-stat, T2.0H, T3.0H, M0t90, T3.30H, Sw, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigA" /TUshortPSig="0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1093" promotor_-10 complement(2487506..2487525) /Source="Nicolas_upshift_promotors" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2487513 /Source="Nicolas_upshifts" /id="U2240" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.300699300699301" /psig="0.822177822177822" /xcortree=292 /SigmaFactorBS="ccggagaggtcctaaccctttaagtaattccgaaacagtctc aagcaagaagttcacgaaaAATAGTATACTGTGTTTAAGtctaatttgcaaggtgcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2487514..2487533 /Source="Nicolas_upshift_promotors" /id="U2240" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.300699300699301" /psig="0.822177822177822" /xcortree=292 /SigmaFactorBS="ccggagaggtcctaaccctttaagtaattccgaaacagtctc aagcaagaagttcacgaaaAATAGTATACTGTGTTTAAGtctaatttgcaaggtgcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2487526) /Source="Nicolas_upshifts" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2487540..2487546) /Source="Nicolas_upshift_promotors" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2487604..2487615) /Source="Nicolas_upshift_promotors" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2487610..2488632) /gene="gapB" /locus_tag="BSU_29020" /old_locus_tag="BSU29020" /EC_number="1.2.1.59" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10799476, 10844697, 15720552, 22720735, 26735940, 27449348, 28760849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10799476, 10844697, 15720552, 22720735, 26735940, 27449348, 28760849; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyceraldehyde-3-phosphate dehydrogenase (NADP-dependent, gluconeogenesis)" /protein_id="NP_390780.1" /db_xref="EnsemblGenomes-Gn:BSU29020" /db_xref="EnsemblGenomes-Tr:CAB14862" /db_xref="GOA:O34425" /db_xref="InterPro:IPR006424" /db_xref="InterPro:IPR020828" /db_xref="InterPro:IPR020829" /db_xref="InterPro:IPR020830" /db_xref="InterPro:IPR020831" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12592" /db_xref="UniProtKB/Swiss-Prot:O34425" /translation="MKVKVAINGFGRIGRMVFRKAMLDDQIQVVAINASYSAETLAHL IKYDTIHGRYDKEVVAGEDSLIVNGKKVLLLNSRDPKQLPWREYDIDIVVEATGKFNA KDKAMGHIEAGAKKVILTAPGKNEDVTIVMGVNEDQFDAERHVIISNASCTTNCLAPV VKVLDEEFGIESGLMTTVHAYTNDQKNIDNPHKDLRRARACGESIIPTTTGAAKALSL VLPHLKGKLHGLALRVPVPNVSLVDLVVDLKTDVTAEEVNEAFKRAAKTSMYGVLDYS DEPLVSTDYNTNPHSAVIDGLTTMVMEDRKVKVLAWYDNEWGYSCRVVDLIRHVAARM KHPSAV*" /label="gapB CDS" gene complement(2487610..2488632) /gene="gapB" /locus_tag="BSU_29020" /old_locus_tag="BSU29020" /label="gapB gene" upshifts complement(2487611) /Source="Nicolas_upshifts" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2487630..2487636) /Source="Nicolas_upshift_promotors" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2488676..2488695) /Source="Nicolas_upshift_promotors" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2488707) /Source="Nicolas_upshifts" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2488708..2488715) /Source="Nicolas_upshift_promotors" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2488838..2489218) /gene="ytcD" /locus_tag="BSU_29030" /old_locus_tag="BSU29030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (HxlR family)" /protein_id="NP_390781.1" /db_xref="EnsemblGenomes-Gn:BSU29030" /db_xref="EnsemblGenomes-Tr:CAB14863" /db_xref="GOA:O34533" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2HZT" /db_xref="SubtiList:BG13831" /db_xref="UniProtKB/Swiss-Prot:O34533" /translation="MEKKKYNISVEATLEVIGGKWKCVILCHLTHGKKRTSELKRLMP NITQKMLTQQLRELEADGVINRIVYNQVPPKVEYELSEYGRSLEGILDMLCAWGANHI NRVYGDTFSVLEESVLNDKLKQES*" /label="ytcD CDS" gene complement(2488838..2489218) /gene="ytcD" /locus_tag="BSU_29030" /old_locus_tag="BSU29030" /label="ytcD gene" downshifts complement(2488862) /Source="Nicolas_upshifts" /id="D1488" /incds=0 /nref=17 /ntot=164 /MaxReadThrough="1.55675" /MaxDrop="3.64816" /score="18.9828659" /energy="-15.3" /TU="NA" /idTUdmin="U2245" /TUdmin=3 /isTUend="TRUE" /label="downshifts" S_feature complement(2489219..2489349) /Source="Nicolas_S_feature" /locus_tag="new_2968641_2968771_c" /HighExp="dia15, Diami, dia5, LBGstat, G180, Etha, S5, LBGtran, H2O2, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.972" /TUlongSig="NA" /TUlongPSig="NA" /label="S1094" promotor_-35 2489274..2489278 /Source="Nicolas_upshift_promotors" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2489294..2489313 /Source="Nicolas_upshift_promotors" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2489295..2489401 /Source="Nicolas_S_feature" /locus_tag="new_2968717_2968823" /HighExp="Diami, G180, G135, LBGstat, G150, LBGexp, Paraq, Oxctl, dia5, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.972" /TUlongSig="NA" /TUlongPSig="NA" /label="S1095" upshifts 2489295 /Source="Nicolas_upshifts" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2489339..2489358) /Source="Nicolas_upshift_promotors" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2489349) /Source="Nicolas_upshifts" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2489373..2489380) /Source="Nicolas_upshift_promotors" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2489402..2490592 /gene="ytbD" /locus_tag="BSU_29040" /old_locus_tag="BSU29040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23504016; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390782.1" /db_xref="EnsemblGenomes-Gn:BSU29040" /db_xref="EnsemblGenomes-Tr:CAB14864" /db_xref="GOA:O34367" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13825" /db_xref="UniProtKB/Swiss-Prot:O34367" /translation="MTSANKSNIPALLALAVSAFAIGTTEFISVGLLPLIADDLDIPV TTAGLTVSLYALGVTFGAPILTSLTSSMSRKTLLLWIMFIFIAGNTMAATASSIGILL AARVISAFSHGVFMSIGSTIAADIVPEDKRASAISIMFTGLTVATVTGVPFGTFIGQQ FGWRFAFMVIIAVGIIAFITNGILVPSKLRKGTKTTMRDQLKLVTNSRLLLLFVITAL GYGGTFVVFTYLSPLLQEVTGFKAGTVAVILLGYGIAIAIGNMIGGKLSNRNPIAALF YMFIVQAIVLFVLTFTAPYQAAGLITILCMGLLAFMNVPGLQVYVVMLAERFVPSAVD VASAMNIAAFNAGIALGSYLGGVITDSIGLIHTAWIGGLMVVGAVILTGWSRLMEKRD RQEA*" /label="ytbD CDS" gene 2489402..2490592 /gene="ytbD" /locus_tag="BSU_29040" /old_locus_tag="BSU29040" /label="ytbD gene" promotor_-10 complement(2490224..2490242) /Source="Nicolas_upshift_promotors" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2490240) /Source="Nicolas_upshifts" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2490258..2490263) /Source="Nicolas_upshift_promotors" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2490616..2491458 /gene="ytbE" /locus_tag="BSU_29050" /old_locus_tag="BSU29050" /EC_number="1.1.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:19585557, 20981419, 28032445, 28130301" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19585557, 20981419, 28032445, 28130301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous aldo/keto reductase" /protein_id="NP_390783.1" /db_xref="EnsemblGenomes-Gn:BSU29050" /db_xref="EnsemblGenomes-Tr:CAB14865" /db_xref="GOA:O34678" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:3B3D" /db_xref="SubtiList:BG13826" /db_xref="UniProtKB/Swiss-Prot:O34678" /translation="MTTHLQAKATLHNGVEMPWFGLGVFQVEEGSELVNAVKTAIVHG YRSIDTAAIYGNEAGVGEGIREGIEEAGISREDLFITSKVWNADLGYEETLAAFETSL SKLGLDYLDLYLIHWPVEGKYKEAWRALETLYKEGRIKAIGVSNFQIHHLEDLMTAAE IKPMINQVEFHPRLTQKELIRYCQNQGIQMEAWSPLMQGQLLDHPVLADIAQTYNKSV AQIILRWDLQHGIITIPKSTKEHRIKENASVFDFELTQDDMNRIDALNENLRVGPDPD NFDF*" /label="ytbE CDS" gene 2490616..2491458 /gene="ytbE" /locus_tag="BSU_29050" /old_locus_tag="BSU29050" /label="ytbE gene" promotor_-35 2491231..2491236 /Source="Nicolas_upshift_promotors" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2491252..2491270 /Source="Nicolas_upshift_promotors" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2491253 /Source="Nicolas_upshifts" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2491451 /Source="Nicolas_upshifts" /id="D1489" /incds=0 /nref=13 /ntot=124 /MaxReadThrough="1.16017" /MaxDrop="5.72508" /score="24.0721062" /energy="-11.4" /TU="NA" /idTUdmin="U2244" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2491491) /Source="Nicolas_upshifts" /id="D1490" /incds=0 /nref=168 /ntot=263 /MaxReadThrough="3.38494" /MaxDrop="6.57333" /score="13.4291259" /energy="-11.4" /TU="NA" /idTUdmin="U2248" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(2491500..2492093) /gene="coaE" /locus_tag="BSU_29060" /old_locus_tag="BSU29060" /EC_number="2.7.1.24" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10939241, 11886213, 12538896, 12682299, 15044829, 15526298, 17603993; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dephosphocoenzyme A kinase" /protein_id="NP_390784.1" /db_xref="EnsemblGenomes-Gn:BSU29060" /db_xref="EnsemblGenomes-Tr:CAB14866" /db_xref="GOA:O34932" /db_xref="InterPro:IPR001977" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13824" /db_xref="UniProtKB/Swiss-Prot:O34932" /translation="MTLVIGLTGGIASGKSTVANMLIEKGITVIDADIIAKQAVEKGM PAYRQIIDEFGEDILLSNGDIDRKKLGALVFTNEQKRLALNAIVHPAVRQEMLNRRDE AVANREAFVVLDIPLLFESKLESLVDKIIVVSVTKELQLERLMKRNQLTEEEAVSRIR SQMPLEEKTARADQVIDNSGTLEETKRQLDEIMNSWA*" /label="coaE CDS" gene complement(2491500..2492093) /gene="coaE" /locus_tag="BSU_29060" /old_locus_tag="BSU29060" /label="coaE gene" CDS complement(2492109..2492741) /gene="spcF" /locus_tag="BSU_29070" /old_locus_tag="BSU29070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23396918; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="membrane calmodulin-like protein essential for stage III sporulation" /protein_id="NP_390785.2" /db_xref="EnsemblGenomes-Gn:BSU29070" /db_xref="EnsemblGenomes-Tr:CAB14867" /db_xref="GOA:C0SP79" /db_xref="InterPro:IPR003810" /db_xref="InterPro:IPR014205" /db_xref="SubtiList:BG13823" /db_xref="UniProtKB/Swiss-Prot:C0SP79" /translation="MQMVSILLLALAVSLDSFSVGFTYGLRKMKIPFKAILVIACCSG AVMFISMLIGSFLTKFFPVYVTEKLGGLILVGIGAWVLYQFFKPAKDKEYLLHEKTLL NLEVRSLGIVIHILRKPMSADIDKSGVINGIEAVLLGFALSIDAFGAGIGAAILGFSP IVMSIAVAIMSSLFVSIGINAGHFLSKWKWIDKMAFLPGLLLITIGLWKL*" /label="spcF CDS" gene complement(2492109..2492741) /gene="spcF" /locus_tag="BSU_29070" /old_locus_tag="BSU29070" /label="spcF gene" S_feature complement(2492742..2492906) /Source="Nicolas_S_feature" /locus_tag="new_2972164_2972328_c" /HighExp="LPhT, dia15, Sw, LBGtran, LBGstat, H2O2, Diami, G135, Lbstat, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1096" CDS complement(2492907..2493737) /gene="mutM" /locus_tag="BSU_29080" /old_locus_tag="BSU29080" /EC_number="3.2.2.23" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15109717, 25825434, 28517932; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formamidopyrimidine-DNA glycosylase; 5-hydroxymethyl-uracil DNA-glycosylase" /protein_id="NP_390786.2" /db_xref="EnsemblGenomes-Gn:BSU29080" /db_xref="EnsemblGenomes-Tr:CAB14868" /db_xref="GOA:O34403" /db_xref="InterPro:IPR000214" /db_xref="InterPro:IPR010663" /db_xref="InterPro:IPR010979" /db_xref="InterPro:IPR012319" /db_xref="InterPro:IPR015886" /db_xref="InterPro:IPR015887" /db_xref="InterPro:IPR020629" /db_xref="InterPro:IPR035937" /db_xref="SubtiList:BG12628" /db_xref="UniProtKB/Swiss-Prot:O34403" /translation="MPELPEVETVRRTLTGLVKGKTIKSVEIRWPNIIKRPAEPEEFA RKLAGETIQSIGRRGKFLLFHLDHYVMVSHLRMEGKYGLHQAEEPDDKHVHVIFTMTD GTQLRYRDVRKFGTMHLFKPGEEAGELPLSQLGPEPDAEEFTSAYLKDRLAKTNRAVK TALLDQKTVVGLGNIYVDEALFRAGVHPETKANQLSDKTIKTLHAEIKNTLQEAIDAG GSTVRSYINSQGEIGMFQLQHFVYGKKDEPCKNCGTMISKIVVGGRGTHFCAKCQTKK *" /label="mutM CDS" gene complement(2492907..2493737) /gene="mutM" /locus_tag="BSU_29080" /old_locus_tag="BSU29080" /label="mutM gene" CDS complement(2493760..2496402) /gene="polA" /locus_tag="BSU_29090" /old_locus_tag="BSU29090" /EC_number="2.7.7.7" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3125407, 6777244, 9231429, 12081953, 17905985, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3125407, 6777244, 9231429, 12081953, 17905985, 27399782; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase I" /protein_id="NP_390787.1" /db_xref="EnsemblGenomes-Gn:BSU29090" /db_xref="EnsemblGenomes-Tr:CAB14869" /db_xref="GOA:O34996" /db_xref="InterPro:IPR001098" /db_xref="InterPro:IPR002298" /db_xref="InterPro:IPR002421" /db_xref="InterPro:IPR002562" /db_xref="InterPro:IPR008918" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR018320" /db_xref="InterPro:IPR019760" /db_xref="InterPro:IPR020045" /db_xref="InterPro:IPR020046" /db_xref="InterPro:IPR029060" /db_xref="InterPro:IPR036279" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12656" /db_xref="UniProtKB/Swiss-Prot:O34996" /translation="MTERKKLVLVDGNSLAYRAFFALPLLSNDKGVHTNAVYGFAMIL MKMLEDEKPTHMLVAFDAGKTTFRHGTFKEYKGGRQKTPPELSEQMPFIRELLDAYQI SRYELEQYEADDIIGTLAKSAEKDGFEVKVFSGDKDLTQLATDKTTVAITRKGITDVE FYTPEHVKEKYGLTPEQIIDMKGLMGDSSDNIPGVPGVGEKTAIKLLKQFDSVEKLLE SIDEVSGKKLKEKLEEFKDQALMSKELATIMTDAPIEVSVSGLEYQGFNREQVIAIFK DLGFNTLLERLGEDSAEAEQDQSLEDINVKTVTDVTSDILVSPSAFVVEQIGDNYHEE PILGFSIVNETGAYFIPKDIAVESEVFKEWVENDEQKKWVFDSKRAVVALRWQGIELK GAEFDTLLAAYIINPGNSYDDVASVAKDYGLHIVSSDESVYGKGAKRAVPSEDVLSEH LGRKALAIQSLREKLVQELENNDQLELFEELEMPLALILGEMESTGVKVDVDRLKRMG EELGAKLKEYEEKIHEIAGEPFNINSPKQLGVILFEKIGLPVVKKTKTGYSTSADVLE KLADKHDIVDYILQYRQIGKLQSTYIEGLLKVTRPDSHKVHTRFNQALTQTGRLSSTD PNLQNIPIRLEEGRKIRQAFVPSEKDWLIFAADYSQIELRVLAHISKDENLIEAFTND MDIHTKTAMDVFHVAKDEVTSAMRRQAKAVNFGIVYGISDYGLSQNLGITRKEAGAFI DRYLESFQGVKAYMEDSVQEAKQKGYVTTLMHRRRYIPELTSRNFNIRSFAERTAMNT PIQGSAADIIKKAMIDMAAKLKEKQLKARLLLQVHDELIFEAPKEEIEILEKLVPEVM EHALALDVPLKVDFASGPSWYDAK*" /label="polA CDS" gene complement(2493760..2496402) /gene="polA" /locus_tag="BSU_29090" /old_locus_tag="BSU29090" /label="polA gene" promotor_-10 complement(2496457..2496476) /Source="Nicolas_upshift_promotors" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2496466) /Source="Nicolas_upshifts" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2496490..2496497) /Source="Nicolas_upshift_promotors" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2496526..2496645) /Source="Nicolas_S_feature" /locus_tag="new_2975948_2976067_c" /HighExp="M0t90, M40t90, M9-stat, Lbstat, Sw, T1.30H, T1.0H, S4, S3, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1097" downshifts complement(2496569) /Source="Nicolas_upshifts" /id="D1491" /incds=0 /nref=48 /ntot=175 /MaxReadThrough="5.58383" /MaxDrop="3.85702" /score="15.0073484" /energy="-12.2" /TU="U2249" /idTUdmin="U2254" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(2496646..2498385) /gene="phoR" /locus_tag="BSU_29100" /old_locus_tag="BSU29100" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10433720, 12486063, 14762014, 15205429, 16430694, 16452408, 17085571, 20487291, 23145827, 25315493, 25355628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10433720, 12486063, 14762014, 15205429, 16430694, 16452408, 17085571, 20487291, 23145827, 25315493, 25355628; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_390788.1" /db_xref="EnsemblGenomes-Gn:BSU29100" /db_xref="EnsemblGenomes-Tr:CAB14870" /db_xref="GOA:P23545" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR031967" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:3CWF" /db_xref="SubtiList:BG10364" /db_xref="UniProtKB/Swiss-Prot:P23545" /translation="MNKYRVRLFSVFVVCMILVFCVLGLFLQQLFETSDQRKAEEHIE KEAKYLASLLDAGNLNNQANEKIIKDAGGALDVSASVIDTDGKVLYGSNGRSADSQKV QALVSGHEGILSTTDNKLYYGLSLRSEGEKTGYVLLSASEKSDGLKGELWGMLTASLC TAFIVIVYFYSSMTSRYKRSIESATNVATELSKGNYDARTYGGYIRRSDKLGHAMNSL AIDLMEMTRTQEMQRDRLLTVIENIGSGLIMIDGRGFINLVNRSYAKQFHINPNHMLR RLYHDAFEHEEVIQLVEDIFMTETKKCKLLRLPIKIERRYFEVDGVPIMGPDDEWKGI VLVFHDMTETKKLEQMRKDFVANVSHELKTPITSIKGFTETLLDGAMEDKEALSEFLS IILKESERLQSLVQDLLDLSKIEQQNFTLSIETFEPAKMLGEIETLLKHKADEKGISL HLNVPKDPQYVSGDPYRLKQVFLNLVNNALTYTPEGGSVAINVKPREKDIQIEVADSG IGIQKEEIPRIFERFYRVDKDRSRNSGGTGLGLAIVKHLIEAHEGKIDVTSELGRGTV FTVTLKRAAEKSA*" /label="phoR CDS" gene complement(2496646..2498385) /gene="phoR" /locus_tag="BSU_29100" /old_locus_tag="BSU29100" /label="phoR gene" CDS complement(2498378..2499100) /gene="phoP" /locus_tag="BSU_29110" /old_locus_tag="BSU29110" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14762014, 14973033, 15205429, 16030210, 16452408, 16816204, 16980498, 17085571, 20487291, 22720735, 23145827, 25315493, 25355628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762014, 14973033, 15205429, 16030210, 16452408, 16816204, 16980498, 17085571, 20487291, 22720735, 23145827, 25315493, 25355628; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_390789.2" /db_xref="EnsemblGenomes-Gn:BSU29110" /db_xref="EnsemblGenomes-Tr:CAB14871" /db_xref="GOA:P13792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1MVO" /db_xref="SubtiList:BG10363" /db_xref="UniProtKB/Swiss-Prot:P13792" /translation="MNKKILVVDDEESIVTLLQYNLERSGYDVITASDGEEALKKAET EKPDLIVLDVMLPKLDGIEVCKQLRQQKLMFPILMLTAKDEEFDKVLGLELGADDYMT KPFSPREVNARVKAILRRSEIAAPSSEMKNDEMEGQIVIGDLKILPDHYEAYFKESQL ELTPKEFELLLYLGRHKGRVLTRDLLLSAVWNYDFAGDTRIVDVHISHLRDKIENNTK KPIYIKTIRGLGYKLEEPKMNE*" /label="phoP CDS" gene complement(2498378..2499100) /gene="phoP" /locus_tag="BSU_29110" /old_locus_tag="BSU29110" /label="phoP gene" promotor_-10 complement(2499168..2499187) /Source="Nicolas_upshift_promotors" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2499178) /Source="Nicolas_upshifts" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2499180..2499280) /Source="Nicolas_S_feature" /locus_tag="new_2978602_2978702_c" /HighExp="M40t90, T1.30H, T1.0H, M0t90, M9-stat, T2.0H, T2.30H, T3.0H, T0.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1098" promotor_-35 complement(2499201..2499207) /Source="Nicolas_upshift_promotors" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2499312..2500250) /gene="mdh" /locus_tag="BSU_29120" /old_locus_tag="BSU29120" /EC_number="1.1.1.37" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6319195, 8550482, 12034826, 16788182, 22720735, 23136871, 24325460, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6319195, 8550482, 12034826, 16788182, 22720735, 23136871, 24325460, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate dehydrogenase (NAD-dependent)" /protein_id="NP_390790.1" /db_xref="EnsemblGenomes-Gn:BSU29120" /db_xref="EnsemblGenomes-Tr:CAB14872" /db_xref="GOA:P49814" /db_xref="InterPro:IPR001236" /db_xref="InterPro:IPR001557" /db_xref="InterPro:IPR011275" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR022383" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11386" /db_xref="UniProtKB/Swiss-Prot:P49814" /translation="MGNTRKKVSVIGAGFTGATTAFLIAQKELADVVLVDIPQLENPT KGKALDMLEASPVQGFDAKITGTSNYEDTAGSDIVVITAGIARKPGMSRDDLVSTNEK IMRSVTQEIVKYSPDSIIVVLTNPVDAMTYAVYKESGFPKERVIGQSGVLDTARFRTF VAEELNLSVKDVTGFVLGGHGDDMVPLVRYSYAGGIPLETLIPKERIDAIVERTRKGG GEIVNLLGNGSAYYAPAASLTEMVEAILKDQRRVLPTIAYLEGEYGYEGIYLGVPTIV GGNGLEQIIELELTDYERAQLNKSVESVKNVMKVLS*" /label="mdh CDS" gene complement(2499312..2500250) /gene="mdh" /locus_tag="BSU_29120" /old_locus_tag="BSU29120" /label="mdh gene" downshifts complement(2499325) /Source="Nicolas_upshifts" /id="D1492" /incds=0 /nref=200 /ntot=242 /MaxReadThrough="8.27126" /MaxDrop="7.40884" /score="-0.758981483" /energy="-13.5" /TU="U2251,U2254" /idTUdmin="U2250" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(2500294..2501565) /gene="icd" /locus_tag="BSU_29130" /old_locus_tag="BSU29130" /EC_number="1.1.1.42" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8045898, 9244258, 11290745, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045898, 9244258, 11290745, 24325460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isocitrate dehydrogenase" /protein_id="NP_390791.1" /db_xref="EnsemblGenomes-Gn:BSU29130" /db_xref="EnsemblGenomes-Tr:CAB14873" /db_xref="GOA:P39126" /db_xref="InterPro:IPR004439" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="PDB:1HQS" /db_xref="SubtiList:BG10856" /db_xref="UniProtKB/Swiss-Prot:P39126" /translation="MAQGEKITVSNGVLNVPNNPIIPFIEGDGTGPDIWNAASKVLEA AVEKAYKGEKKITWKEVYAGEKAYNKTGEWLPAETLDVIREYFIAIKGPLTTPVGGGI RSLNVALRQELDLFVCLRPVRYFTGVPSPVKRPEDTDMVIFRENTEDIYAGIEYAKGS EEVQKLISFLQNELNVNKIRFPETSGIGIKPVSEEGTSRLVRAAIDYAIEHGRKSVTL VHKGNIMKFTEGAFKNWGYELAEKEYGDKVFTWAQYDRIAEEQGKDAANKAQSEAEAA GKIIIKDSIADIFLQQILTRPNEFDVVATMNLNGDYISDALAAQVGGIGIAPGANINY ETGHAIFEATHGTAPKYAGLDKVNPSSVILSGVLLLEHLGWNEAADLVIKSMEKTIAS KVVTYDFARLMDGATEVKCSEFGEELIKNMD*" /label="icd CDS" gene complement(2500294..2501565) /gene="icd" /locus_tag="BSU_29130" /old_locus_tag="BSU29130" /label="icd gene" misc_feature complement(2501350..2501369) /Source="Nicolas_upshift_promotors" /id="U2250" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.46953046953047" /psig="0.95004995004995" /xcortree=3208 /SigmaFactorBS="agcatacaaaggcgaaaagaaaattacatggaaagaagttta cgccggagaaaAGGCTTATAATAAAACAGGTgagtggctccctgctgaaacattagat g" /listShort="mdh" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2501362) /Source="Nicolas_upshifts" /id="U2250" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.46953046953047" /psig="0.95004995004995" /xcortree=3208 /SigmaFactorBS="agcatacaaaggcgaaaagaaaattacatggaaagaagttta cgccggagaaaAGGCTTATAATAAAACAGGTgagtggctccctgctgaaacattagat g" /listShort="mdh" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2501566..2501648) /Source="Nicolas_S_feature" /locus_tag="new_2980988_2981070_c" /HighExp="T2.30H, M40t90, T1.0H, T-3.40H, HiOs, T3.30H, T3.0H, T0.0H, Lbstat, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1099" upshifts complement(2501648) /Source="Nicolas_upshifts" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="upshifts" S_feature complement(2501650..2501728) /Source="Nicolas_S_feature" /locus_tag="new_2981072_2981150_c" /HighExp="T2.30H, T3.30H, T1.0H, M40t90, T3.0H, Lbstat, M0t90, T0.0H, HiOs, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1100" promotor_-10 complement(2501650..2501669) /Source="Nicolas_upshift_promotors" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="promotor_-10" promotor_-35 complement(2501685..2501689) /Source="Nicolas_upshift_promotors" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="promotor_-35" CDS complement(2501729..2502847) /gene="citZ" /locus_tag="BSU_29140" /old_locus_tag="BSU29140" /EC_number="2.3.3.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8655569, 10656796, 11985717, 12100558, 19202299, 22720735, 23139400, 23354745" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8655569, 10656796, 11985717, 12100558, 19202299, 22720735, 23139400, 23354745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="citrate synthase II" /protein_id="NP_390792.1" /db_xref="EnsemblGenomes-Gn:BSU29140" /db_xref="EnsemblGenomes-Tr:CAB14874" /db_xref="GOA:P39120" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR011278" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="SubtiList:BG10855" /db_xref="UniProtKB/Swiss-Prot:P39120" /translation="MTATRGLEGVVATTSSVSSIIDDTLTYVGYDIDDLTENASFEEI IYLLWHLRLPNKKELEELKQQLAKEAAVPQEIIEHFKSYSLENVHPMAALRTAISLLG LLDSEADTMNPEANYRKAIRLQAKVPGLVAAFSRIRKGLEPVEPREDYGIAENFLYTL NGEEPSPIEVEAFNKALILHADHELNASTFTARVCVATLSDIYSGITAAIGALKGPLH GGANEGVMKMLTEIGEVENAEPYIRAKLEKKEKIMGFGHRVYKHGDPRAKHLKEMSKR LTNLTGESKWYEMSIRIEDIVTSEKKLPPNVDFYSASVYHSLGIDHDLFTPIFAVSRM SGWLAHILEQYDNNRLIRPRADYTGPDKQKFVPIEERA*" /label="citZ CDS" gene complement(2501729..2502847) /gene="citZ" /locus_tag="BSU_29140" /old_locus_tag="BSU29140" /label="citZ gene" downshifts 2502342 /Source="Nicolas_upshifts" /id="D1493" /incds=1 /nref=2 /ntot=63 /MaxReadThrough="1.41638" /MaxDrop="3.70762" /score="40.6931963" /energy="-9.9" /TU="NA" /idTUdmin="U2252" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" misc_feature 2502689..2502692 /Source="Nicolas_upshift_promotors" /id="U2252" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.002997002997003" /xcortree=74 /SigmaFactorBS="cagcttcctttgcaagctgctgctttaactcttcaagctctt ttttgtttggCAGCcttagatgccaaagcaagtagatgatttcttcaaaacttgcatt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2502697 /Source="Nicolas_upshifts" /id="U2252" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.002997002997003" /xcortree=74 /SigmaFactorBS="cagcttcctttgcaagctgctgctttaactcttcaagctctt ttttgtttggCAGCcttagatgccaaagcaagtagatgatttcttcaaaacttgcatt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2502826 /Source="Nicolas_upshifts" /id="D1494" /incds=0 /nref=1 /ntot=126 /MaxReadThrough="2.98678" /MaxDrop="3.07929" /score="40.6931963" /energy="-9.9" /TU="U2252" /idTUdmin="U2252" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" S_feature complement(2502848..2503054) /Source="Nicolas_S_feature" /locus_tag="new_2982270_2982476_c" /HighExp="T3.0H, T3.30H, T2.30H, T4.0H, M0t90, T2.0H, T1.30H, T5.0H, BC, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1101" misc_feature 2503022..2503034 /Source="Nicolas_upshift_promotors" /id="U2253" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.464535464535465" /xcortree=721 /SigmaFactorBS="ctggaactaaaaccctttgcttttgaaagaacataacaaatt tttataaGCTTATTTAAGTTtaagcctattctcattataaacaataatcagacatttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2503033 /Source="Nicolas_upshifts" /id="U2253" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.464535464535465" /xcortree=721 /SigmaFactorBS="ctggaactaaaaccctttgcttttgaaagaacataacaaatt tttataaGCTTATTTAAGTTtaagcctattctcattataaacaataatcagacatttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2503040..2503059) /Source="Nicolas_upshift_promotors" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2503054) /Source="Nicolas_upshifts" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2503074..2503078) /Source="Nicolas_upshift_promotors" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2503174) /Source="Nicolas_upshifts" /id="D1495" /incds=0 /nref=116 /ntot=204 /MaxReadThrough="6.4946" /MaxDrop="5.00031" /score="29.3344463" /energy="-8.1" /TU="NA" /idTUdmin="U2255" /TUdmin=14 /isTUend="TRUE" /label="downshifts" CDS complement(2503181..2503645) /gene="ytwI" /locus_tag="BSU_29150" /old_locus_tag="BSU29150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390793.1" /db_xref="EnsemblGenomes-Gn:BSU29150" /db_xref="EnsemblGenomes-Tr:CAB14875" /db_xref="GOA:O34811" /db_xref="InterPro:IPR007382" /db_xref="SubtiList:BG13933" /db_xref="UniProtKB/Swiss-Prot:O34811" /translation="MFTQANLFLILLLAIALIAKNQSLLFAVSVLLIIKIVGLDQKLF PTIQSKGINWGVTIITIAVLVPIATGEIGFKQLGEAMRSSYAWIALGAGIAVALIAKN GLTLLENDPHITTALVIGTILAVALFGGVAVGPLIGAGIAYLAMQIVKLFTS*" /label="ytwI CDS" gene complement(2503181..2503645) /gene="ytwI" /locus_tag="BSU_29150" /old_locus_tag="BSU29150" /label="ytwI gene" promotor_-10 complement(2503658..2503677) /Source="Nicolas_upshift_promotors" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2503672) /Source="Nicolas_upshifts" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2503674..2504859) /Source="Nicolas_S_feature" /locus_tag="new_2983096_2984281_c" /HighExp="G135, G180, LBGstat, G150, LBGtran, S0, Paraq, Oxctl, H2O2, LBGexp" /AntisenseName="ytvI" /AntisenseCor="-0.73323145377324295" /AntisenseRegPval="-45.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1102" promotor_-35 2503674..2503679 /Source="Nicolas_upshift_promotors" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2503690..2503698) /Source="Nicolas_upshift_promotors" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2503694..2503712 /Source="Nicolas_upshift_promotors" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2503700 /Source="Nicolas_upshifts" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="upshifts" CDS 2503742..2504857 /gene="ytvI" /locus_tag="BSU_29160" /old_locus_tag="BSU29160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12662922, 15849754, 16850406, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sporulation-related permease" /protein_id="NP_390794.1" /db_xref="EnsemblGenomes-Gn:BSU29160" /db_xref="EnsemblGenomes-Tr:CAB14876" /db_xref="GOA:O34991" /db_xref="InterPro:IPR002549" /db_xref="InterPro:IPR014227" /db_xref="SubtiList:BG13930" /db_xref="UniProtKB/Swiss-Prot:O34991" /translation="MNQSYITIFFRTLFVISMTAGSIAAAYYSFPLTYPFLIALILSS VIHPVVDYLDKVTGFPRTINVLGVLAFFLLAAFGVLTILVAEIVTGTAYLAKTLPPHI STFISYCEKLFTTHIQPLYNELTLLFQELETNQQASIVTHIQTLGDSAAKNAGLLLSH ILEMIPRFFALLPNTAAVLIFSLLATFFMTKDWHKLKAMLVLILPDRVTANSKAISSE LKKAMTGFIKAQAVLVFITMVIVFIGLSLLKVEHAATIAFLIGLVDLLPYLGAGSVFV PWILYLSITGQLPQAIGIGILYLVVLIQRQLTEPKILSKSIGIDPLATLIALFAGFKL FGFLGLIAGPAVLVIIQAFITTGALKEIWSYITVQQK*" /label="ytvI CDS" gene 2503742..2504857 /gene="ytvI" /locus_tag="BSU_29160" /old_locus_tag="BSU29160" /label="ytvI gene" downshifts 2504828 /Source="Nicolas_upshifts" /id="D1496" /incds=0 /nref=2 /ntot=24 /MaxReadThrough="1.639" /MaxDrop="3.31897" /score="37.6858539" /energy="-16.7" /TU="NA" /idTUdmin="U2256" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2504890..2505273) /gene="ytzA" /locus_tag="BSU_29170" /old_locus_tag="BSU29170" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15302217, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390795.1" /db_xref="EnsemblGenomes-Gn:BSU29170" /db_xref="EnsemblGenomes-Tr:CAB14877" /db_xref="GOA:O32064" /db_xref="InterPro:IPR007313" /db_xref="SubtiList:BG13935" /db_xref="UniProtKB/Swiss-Prot:O32064" /translation="MRFLFLLFIVFPAIEIGIFLFLGNLIGILPTVLFMILTGIIGAA AAKKQGTEVYYKVQRDLQYGKMPGEAIADGLCIFIGGLLLMLPGFLSDLAGACLLIPF TRGWCKPILFKWLRGMSKNKRIIIK*" /label="ytzA CDS" gene complement(2504890..2505273) /gene="ytzA" /locus_tag="BSU_29170" /old_locus_tag="BSU29170" /label="ytzA gene" downshifts complement(2504904) /Source="Nicolas_upshifts" /id="D1497" /incds=0 /nref=181 /ntot=256 /MaxReadThrough="4.28884" /MaxDrop="5.74703" /score="18.319512" /energy="-13.8" /TU="NA" /idTUdmin="U2257" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2505274..2505365) /Source="Nicolas_S_feature" /locus_tag="new_2984696_2984787_c" /HighExp="G135, LBGtran, G150, LBGexp, M0t45, Lbexp, S0, G180, Oxctl, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1103" CDS complement(2505366..2507123) /gene="pyk" /locus_tag="BSU_29180" /old_locus_tag="BSU29180" /EC_number="2.7.1.40" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559165, 10932722, 10966427, 11489127, 17022686, 18586936, 22846916, 24825009" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559165, 10932722, 10966427, 11489127, 17022686, 18586936, 22846916, 24825009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate kinase" /protein_id="NP_390796.1" /db_xref="EnsemblGenomes-Gn:BSU29180" /db_xref="EnsemblGenomes-Tr:CAB14878" /db_xref="GOA:P80885" /db_xref="InterPro:IPR001697" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR011037" /db_xref="InterPro:IPR015793" /db_xref="InterPro:IPR015795" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018209" /db_xref="InterPro:IPR036918" /db_xref="SubtiList:BG12661" /db_xref="UniProtKB/Swiss-Prot:P80885" /translation="MRKTKIVCTIGPASESIEMLTKLMESGMNVARLNFSHGDFEEHG ARIKNIREASKKLGKNVGILLDTKGPEIRTHTMENGGIELETGKELIISMDEVVGTTD KISVTYEGLVHDVEQGSTILLDDGLIGLEVLDVDAAKREIKTKVLNNGTLKNKKGVNV PGVSVNLPGITEKDARDIVFGIEQGVDFIAPSFIRRSTDVLEIRELLEEHNAQDIQII PKIENQEGVDNIDAILEVSDGLMVARGDLGVEIPAEEVPLVQKELIKKCNALGKPVIT ATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAAGSYPVEAVQTMHNIASR SEEALNYKEILSKRRDQVGMTITDAIGQSVAHTAINLNAAAIVTPTESGHTARMIAKY RPQAPIVAVTVNDSISRKLALVSGVFAESGQNASSTDEMLEDAVQKSLNSGIVKHGDL IVITAGTVGESGTTNLMKVHTVGDIIAKGQGIGRKSAYGPVVVAQNAKEAEQKMTDGA VLVTKSTDRDMIASLEKASALITEEGGLTSHAAVVGLSLGIPVIVGLENATSILTDGQ DITVDASRGAVYQGRASVL*" /label="pyk CDS" gene complement(2505366..2507123) /gene="pyk" /locus_tag="BSU_29180" /old_locus_tag="BSU29180" /label="pyk gene" CDS complement(2507166..2508125) /gene="pfkA" /locus_tag="BSU_29190" /old_locus_tag="BSU29190" /EC_number="2.7.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12450869, 12622823, 12682299, 19193632, 20473954, 22198292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12450869, 12622823, 12682299, 19193632, 20473954, 22198292; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-phosphofructokinase" /protein_id="NP_390797.1" /db_xref="EnsemblGenomes-Gn:BSU29190" /db_xref="EnsemblGenomes-Tr:CAB14879" /db_xref="GOA:O34529" /db_xref="InterPro:IPR000023" /db_xref="InterPro:IPR012003" /db_xref="InterPro:IPR012828" /db_xref="InterPro:IPR015912" /db_xref="InterPro:IPR022953" /db_xref="InterPro:IPR035966" /db_xref="PDB:4A3S" /db_xref="SubtiList:BG12644" /db_xref="UniProtKB/Swiss-Prot:O34529" /translation="MKRIGVLTSGGDSPGMNAAVRAVVRKAIYHDVEVYGIYNGYAGL ISGKIEKLELGSVGDIIHRGGTKLYTARCPEFKTVEGREKGIANLKKLGIEGLVVIGG DGSYMGAKKLTEHGFPCVGVPGTIDNDIPGTDFTIGFDTALNTVIDAIDKIRDTATSH ERTYVIEVMGRHAGDIALWAGLAGGAESILIPEADYDMHEIIARLKRGHERGKKHSII IVAEGVGSGVEFGKRIEEETNLETRVSVLGHIQRGGSPSAADRVLASRLGAYAVELLL EGKGGRCVGIQNNKLVDHDIIEILETKHTVEQNMYQLSKELSI*" /label="pfkA CDS" gene complement(2507166..2508125) /gene="pfkA" /locus_tag="BSU_29190" /old_locus_tag="BSU29190" /label="pfkA gene" S_feature complement(2508126..2508227) /Source="Nicolas_S_feature" /locus_tag="new_2987548_2987649_c" /HighExp="G150, LBGtran, LBGexp, Lbexp, dia0, G180, G135, Oxctl, LBGstat, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1104" promotor_-10 complement(2508216..2508235) /Source="Nicolas_upshift_promotors" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2508227) /Source="Nicolas_upshifts" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2508251..2508255) /Source="Nicolas_upshift_promotors" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2508309..2509286) /gene="accA" /locus_tag="BSU_29200" /old_locus_tag="BSU29200" /EC_number="6.4.1.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11133475, 12682299, 15066985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase (carboxyltransferase alpha subunit)" /protein_id="NP_390798.1" /db_xref="EnsemblGenomes-Gn:BSU29200" /db_xref="EnsemblGenomes-Tr:CAB14880" /db_xref="GOA:O34847" /db_xref="InterPro:IPR001095" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12557" /db_xref="UniProtKB/Swiss-Prot:O34847" /translation="MAPRLEFEKPVIELQTKIAELKKFTQDSDMDLSAEIERLEDRLA KLQDDIYKNLKPWDRVQIARLADRPTTLDYIEHLFTDFFECHGDRAYGDDEAIVGGIA KFHGLPVTVIGHQRGKDTKENLVRNFGMPHPEGYRKALRLMKQADKFNRPIICFIDTK GAYPGRAAEERGQSEAIAKNLFEMAGLRVPVICIVIGEGGSGGALGLGVGNHLHMLEN STYSVISPEGAAALLWKDSSLAKKAAETMKITAPDLKELGIIDHMIKEVKGGAHHDVK LQASYMDETLKQSLKTLLKLSEEELVQQRYEKYKAIGKVSVEDQYIGVN*" /label="accA CDS" gene complement(2508309..2509286) /gene="accA" /locus_tag="BSU_29200" /old_locus_tag="BSU29200" /label="accA gene" downshifts complement(2508336) /Source="Nicolas_upshifts" /id="D1498" /incds=0 /nref=48 /ntot=176 /MaxReadThrough="5.40549" /MaxDrop="5.53933" /score="-3.96100458" /energy="-6.8" /TU="U2259,U2260,U2262,U2263" /idTUdmin="U2260" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" CDS complement(2509271..2510143) /gene="accD" /locus_tag="BSU_29210" /old_locus_tag="BSU29210" /EC_number="6.4.1.2" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11133475, 12682299, 14594796, 15066985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase (carboxyltransferase betasubunit)" /protein_id="NP_390799.2" /db_xref="EnsemblGenomes-Gn:BSU29210" /db_xref="EnsemblGenomes-Tr:CAB14881" /db_xref="GOA:C0SP93" /db_xref="InterPro:IPR000438" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG13926" /db_xref="UniProtKB/Swiss-Prot:C0SP93" /translation="MLKDIFTKKKKYASVPSDQAKHDVPEGIMTKCPKCKKIMLTKEL DKNMRVCMNCDYHFPMNAKQRIESLMDEQSFEEFNQGMLSENPLGFPGYLEKLEKDRE KTSLNEAVVTGKGTIGGHPAVVAVMDSSFRMGSMGSVVGEKITLAIEKAKADKVPFII FTASGGARMQEGVLSLMQMAKTSSALKLFSEEQGLIISVMTHPTTGGVSASFASLGDY NFAEPGALIGFAGRRIIEQTIGEKLPEDFQTAEFLLKHGQLDAVIHRDDMKKTLENLL DMHQTGGDIEWLQD*" /label="accD CDS" gene complement(2509271..2510143) /gene="accD" /locus_tag="BSU_29210" /old_locus_tag="BSU29210" /label="accD gene" promotor_-35 2510105..2510110 /Source="Nicolas_upshift_promotors" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2510126..2510144 /Source="Nicolas_upshift_promotors" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2510130..2511304 /Source="Nicolas_S_feature" /locus_tag="new_2989552_2990726" /HighExp="S5, S8, S6, S7, C30, S4, C90, S3, T5.0H, BC" /AntisenseName="ytsJ" /AntisenseCor="-0.46008986922877199" /AntisenseRegPval="-14.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1105" upshifts 2510130 /Source="Nicolas_upshifts" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2510144..2510227) /Source="Nicolas_S_feature" /locus_tag="new_2989566_2989649_c" /HighExp="LBGstat, T4.0H, LBGtran, T5.0H, C30, dia15, M9-stat, Oxctl, LBGexp, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1106" promotor_-10 complement(2510216..2510235) /Source="Nicolas_upshift_promotors" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2510227) /Source="Nicolas_upshifts" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2510229..2510381) /Source="Nicolas_S_feature" /locus_tag="new_2989651_2989803_c" /HighExp="Diami, BC, dia15, Sw, dia5, M40t90, H2O2, S2, G/S, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1107" promotor_-35 complement(2510251..2510255) /Source="Nicolas_upshift_promotors" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2510383..2510477) /Source="Nicolas_S_feature" /locus_tag="new_2989805_2989899_c" /HighExp="dia15, LBGtran, LBGstat, Diami, LoTm, C90, GM 120, MG 60, M/G, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1108" downshifts complement(2510426) /Source="Nicolas_upshifts" /id="D1499" /incds=0 /nref=52 /ntot=158 /MaxReadThrough="7.72399" /MaxDrop="4.5863" /score="-3.96100458" /energy="-6.8" /TU="U2260,U2262,U2263" /idTUdmin="U2260" /TUdmin="-2178" /isTUend="FALSE" /label="downshifts" CDS complement(2510478..2511710) /gene="maeB" /locus_tag="BSU_29220" /old_locus_tag="BSU29220" /EC_number="1.1.1.40" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 22740702, 23136871, 24325460, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 22740702, 23136871, 24325460, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADP-dependent malic enzyme (conversion of malate into pyruvate, anabolic)" /protein_id="NP_390800.1" /db_xref="EnsemblGenomes-Gn:BSU29220" /db_xref="EnsemblGenomes-Tr:CAB14882" /db_xref="GOA:O34962" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG13922" /db_xref="UniProtKB/Swiss-Prot:O34962" /translation="MSLREEALHLHKVNQGKLESKSKVEVRNAKDLSLAYSPGVAEPC KDIHEDINKVYDYTMKGNMVAVVTDGTAVLGLGNIGPEAALPVMEGKAVLFKSFAGVD AFPIALNTNDVDKIVETVKLLEPTFGGVNLEDIAAPNCFIIEERLKKETNIPVFHDDQ HGTAIVTVAGLVNALKLSGKSMSSIKVVANGAGAAGIAIIKLLHHYGVRDIVMCDSKG AIYEGRPNGMNDVKNEVAKFTNQDRKDGSLKDVIVDADVFIGVSVAGALTKEMVQSMA KDPIIFAMANPNPEIMPEDAREAGASVVGTGRSDFPNQVNNVLAFPGIFRGALDVRAT HINEEMKIAAVEAIASLVSEDELSADYVIPAPFDKRVAPAVAKAVAKAAMETGVARIT VDPEEVAEKTRKLTIIGE*" /label="maeB CDS" gene complement(2510478..2511710) /gene="maeB" /locus_tag="BSU_29220" /old_locus_tag="BSU29220" /label="maeB gene" S_feature complement(2511711..2511827) /Source="Nicolas_S_feature" /locus_tag="new_2991133_2991249_c" /HighExp="dia15, Diami, LBGstat, H2O2, LBGtran, dia5, M40t45, Lbtran, LPhT, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1109" promotor_-10 complement(2511815..2511834) /Source="Nicolas_upshift_promotors" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-10" upshifts complement(2511827) /Source="Nicolas_upshifts" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="upshifts" CDS complement(2511847..2515194) /gene="dnaEC" /locus_tag="BSU_29230" /old_locus_tag="BSU29230" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9799485, 9822387, 10354411, 14593098, 20122408, 22333191, 24106089, 29078353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9799485, 9822387, 10354411, 14593098, 20122408, 22333191, 24106089, 29078353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (alpha subunit), DnaE3" /protein_id="NP_390801.1" /db_xref="EnsemblGenomes-Gn:BSU29230" /db_xref="EnsemblGenomes-Tr:CAB14883" /db_xref="GOA:O34623" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004805" /db_xref="InterPro:IPR011708" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR029460" /db_xref="SubtiList:BG12583" /db_xref="UniProtKB/Swiss-Prot:O34623" /translation="MSFVHLQVHSGYSLLNSAAAVEELVSEADRLGYASLALTDDHVM YGAIQFYKACKARGINPIIGLTASVFTDDSELEAYPLVLLAKSNTGYQNLLKISSVLQ SKSKGGLKPKWLHSYREGIIAITPGEKGYIETLLEGGLFEQAAQASLEFQSIFGKGAF YFSYQPFKGNQVLSEQILKLSEETGIPVTATGDVHYIRKEDKAAYRCLKAIKAGEKLT DAPAEDLPDLDLKPLEEMQNIYREHPEALQASVEIAEQCRVDVSLGQTRLPSFPTPDG TSADDYLTDICMEGLRSRFGKPDERYLRRLQYELDVIKRMKFSDYFLIVWDFMKHAHE KGIVTGPGRGSAAGSLVAYVLYITDVDPIKHHLLFERFLNPERVSMPDIDIDFPDTRR DEVIQYVQQKYGAMHVAQIITFGTLAAKAALRDVGRVFGVSPKEADQLAKLIPSRPGM TLDEARQQSPQLDKRLRESSLLQQVYSIARKIEGLPRHASTHAAGVVLSEEPLTDVVP LQEGHEGIYLTQYAMDHLEDLGLLKMDFLGLRNLTLIESITSMIEKEENIKIDLSSIS YSDDKTFSLLSKGDTTGIFQLESAGMRSVLKRLKPSGLEDIVAVNALYRPGPMENIPL FIDRKHGRAPVHYPHEDLRSILEDTYGVIVYQEQIMMIASRMAGFSLGEADLLRRAVS KKKKEILDRERSHFVEGCLKKEYSVDTANEVYDLIVKFANYGFNRSHAVAYSMIGCQL AYLKAHYPLYFMCGLLTSVIGNEDKISQYLYEAKGSGIRILPPSVNKSSFPFTVENGS VRYSLRAIKSVGVSAVKDIYKARKEKPFEDLFDFCFRVPSKSVNRKMLEALIFSGAMD EFGQNRATLLASIDVALEHAELFAADDDQMGLFLDESFSIKPKYVETEELPLVDLLAF EKETLGIYFSNHPLSAFRKQLTAQGAVSILQAQRAVKRQLSLGVLLSKIKTIRTKTGQ NMAFLTLSDETGEMEAVVFPEQFRQLSPVLREGALLFTAGKCEVRQDKIQFIMSRAEL LEDMDAEKAPSVYIKIESSQHSQEILAKIKRILLEHKGETGVYLYYERQKQTIKLPES FHINADHQVLYRLKELLGQKNVVLKQW*" /label="dnaEC CDS" gene complement(2511847..2515194) /gene="dnaEC" /locus_tag="BSU_29230" /old_locus_tag="BSU29230" /label="dnaEC gene" promotor_-35 complement(2511848..2511855) /Source="Nicolas_upshift_promotors" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-35" promotor_-35 2512859..2512868 /Source="Nicolas_upshift_promotors" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2512880..2512895 /Source="Nicolas_upshift_promotors" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2512880 /Source="Nicolas_upshifts" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2513068..2513087) /Source="Nicolas_upshift_promotors" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2513087) /Source="Nicolas_upshifts" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2513101..2513108) /Source="Nicolas_upshift_promotors" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2515225..2515244) /Source="Nicolas_upshift_promotors" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-10" upshifts complement(2515243) /Source="Nicolas_upshifts" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="upshifts" promotor_-35 complement(2515258..2515265) /Source="Nicolas_upshift_promotors" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-35" promotor_-35 2515283..2515288 /Source="Nicolas_upshift_promotors" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="promotor_-35" upshifts 2515300 /Source="Nicolas_upshifts" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="upshifts" promotor_-10 2515304..2515322 /Source="Nicolas_upshift_promotors" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="promotor_-10" CDS 2515334..2515675 /gene="ytrH" /locus_tag="BSU_29239" /old_locus_tag="BSU29239" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 26735940; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="membrane protein involved in a sporulation process" /protein_id="YP_003097771.1" /db_xref="EnsemblGenomes-Gn:BSU29239" /db_xref="EnsemblGenomes-Tr:CAX52677" /db_xref="GOA:C0H3P8" /db_xref="InterPro:IPR025689" /db_xref="UniProtKB/Swiss-Prot:C0H3P8" /translation="MDQEAGFMVNFINSYFIALGVLIGGALIGGLGAYLAGEPPLTAI TKLANRLKIWALVAAIGGTFDAVYSFERGILEGNTRDIFKQLLLIISAMGGAQSGWLI ISWLTQEHLSS*" /label="ytrH CDS" gene 2515334..2515675 /gene="ytrH" /locus_tag="BSU_29239" /old_locus_tag="BSU29239" /label="ytrH gene" CDS 2515672..2516175 /gene="ytrI" /locus_tag="BSU_29240" /old_locus_tag="BSU29240" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 26735940; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="protein involved in sporulation" /protein_id="NP_390802.3" /db_xref="EnsemblGenomes-Gn:BSU29240" /db_xref="EnsemblGenomes-Tr:CAB14884" /db_xref="GOA:O34460" /db_xref="SubtiList:BG13917" /db_xref="UniProtKB/Swiss-Prot:O34460" /translation="MRVPQHYKKPGWQRFFAGMMCGAVISWFFFLFTYGTFQEEQVSL IEKQKEHVKDLNNQISIYQEDLHKLNEDNKRKLLIQSVSVKLLNGDKYKISQPDKTKF EEHVKDDISEVITKDIESVYQTKDLLKRTIENKVYMINEKKYEATVRELIIYTRLTVE LEISFAT*" /label="ytrI CDS" gene 2515672..2516175 /gene="ytrI" /locus_tag="BSU_29240" /old_locus_tag="BSU29240" /label="ytrI gene" promotor_-35 2516208..2516211 /Source="Nicolas_upshift_promotors" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2516226..2516245 /Source="Nicolas_upshift_promotors" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2516226 /Source="Nicolas_upshifts" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="upshifts" CDS 2516277..2516468 /gene="ytzJ" /locus_tag="BSU_29249" /old_locus_tag="BSU29249" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative sporulation-related conserved protein" /protein_id="YP_003097772.1" /db_xref="EnsemblGenomes-Gn:BSU29249" /db_xref="EnsemblGenomes-Tr:CAX52678" /db_xref="UniProtKB/Swiss-Prot:C0H3P9" /translation="MEVYSDRQLAKDQAARLRQGFSAYAETNSLASLIKKELQSHNLQ VYEDLTDFGCWFIPVTDEH*" /label="ytzJ CDS" gene 2516277..2516468 /gene="ytzJ" /locus_tag="BSU_29249" /old_locus_tag="BSU29249" /label="ytzJ gene" downshifts complement(2516278) /Source="Nicolas_upshifts" /id="D1500" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="2.45109" /MaxDrop="3.19151" /score="-1.37123732" /energy="-6.5" /TU="NA" /idTUdmin="U2268" /TUdmin=220 /isTUend="FALSE" /label="downshifts" downshifts 2516444 /Source="Nicolas_upshifts" /id="D1501" /incds=0 /nref=15 /ntot=107 /MaxReadThrough="6.88261" /MaxDrop="6.74738" /score="-8.58003897" /energy="-4" /TU="U2265" /idTUdmin="U2264" /TUdmin=242 /isTUend="FALSE" /label="downshifts" CDS complement(2516486..2517427) /gene="nrnA" /locus_tag="BSU_29250" /old_locus_tag="BSU29250" /EC_number="3.1.3.7" /EC_number="3.1.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17586819, 19553197, 22102036, 26735940, 28894100" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17586819, 19553197, 22102036, 26735940, 28894100; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nanoRNase (oligoribonuclease) (3'->5'short substrates, 5'->3' long substrates), 3',5'-bisphosphate nucleotidase" /protein_id="NP_390803.1" /db_xref="EnsemblGenomes-Gn:BSU29250" /db_xref="EnsemblGenomes-Tr:CAB14885" /db_xref="GOA:O34600" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="PDB:5IPP" /db_xref="PDB:5IUF" /db_xref="PDB:5IZO" /db_xref="PDB:5J21" /db_xref="SubtiList:BG13910" /db_xref="UniProtKB/Swiss-Prot:O34600" /translation="MKTELIRTISLYDTIILHRHVRPDPDAYGSQCGLTEILRETYPE KNIFAVGTPEPSLSFLYSLDEVDNETYEGALVIVCDTANQERIDDQRYPSGAKLMKID HHPNEDPYGDLLWVDTSASSVSEMIYELYLEGKEHGWKLNTKAAELIYAGIVGDTGRF LFPNTTEKTLKYAGELIQYPFSSSELFNQLYETKLNVVKLNGFIFQNVSLSENGAASV FIKKDTLEKFGTTASEASQLVGTLGNISGIRAWVFFVEEDDQIRVRFRSKGPVINGLA RKYNGGGHPLASGASIYSWDEADRILADLETLCKEHE*" /label="nrnA CDS" gene complement(2516486..2517427) /gene="nrnA" /locus_tag="BSU_29250" /old_locus_tag="BSU29250" /label="nrnA gene" S_feature 2516489..2516860 /Source="Nicolas_S_feature" /locus_tag="new_2995911_2996282" /HighExp="Lbstat, S2, M0t90, M40t90, nit, ferm, S3, BT, M9-stat, S0" /AntisenseName="nrnA" /AntisenseCor="-0.77648424268923499" /AntisenseRegPval="-54.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1110" downshifts complement(2516521) /Source="Nicolas_upshifts" /id="D1502" /incds=0 /nref=25 /ntot=163 /MaxReadThrough="3.12169" /MaxDrop="3.09205" /score="22.5196409" /energy="-7.9" /TU="U2268" /idTUdmin="U2269" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2516829..2516838 /Source="Nicolas_upshift_promotors" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2516852..2516871 /Source="Nicolas_upshift_promotors" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2516862..2517256 /Source="Nicolas_S_feature" /locus_tag="new_2996284_2996678" /HighExp="Lbstat, S2, S7, S8, S6, nit, ferm, M0t90, BT, M40t90" /AntisenseName="nrnA" /AntisenseCor="-0.85531073541330804" /AntisenseRegPval="-77.5" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1111" upshifts 2516862 /Source="Nicolas_upshifts" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2517218..2517224 /Source="Nicolas_upshift_promotors" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2517240..2517259 /Source="Nicolas_upshift_promotors" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2517258..2517557 /Source="Nicolas_S_feature" /locus_tag="new_2996680_2996979" /HighExp="Lbstat, S8, S7, S6, S2, Etha, nit, ferm, BT, M0t90" /AntisenseName="nrnA" /AntisenseCor="-0.84034645112995598" /AntisenseRegPval="-72.2" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK, SigA" /TUshortPSig="0.698, 1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1112" upshifts 2517258 /Source="Nicolas_upshifts" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2517446..2517465) /Source="Nicolas_upshift_promotors" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2517462) /Source="Nicolas_upshifts" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2517464..2517878) /Source="Nicolas_S_feature" /locus_tag="new_2996886_2997300_c" /HighExp="LBGtran, HiTm, G180, G135, G150, Lbtran, LBGexp, Mt0, Paraq, dia0" /AntisenseName="ytpI" /AntisenseCor="-0.70134306018551296" /AntisenseRegPval="-40.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1113" promotor_-35 complement(2517480..2517483) /Source="Nicolas_upshift_promotors" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2517558..2517860 /gene="ytpI" /locus_tag="BSU_29260" /old_locus_tag="BSU29260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390804.1" /db_xref="EnsemblGenomes-Gn:BSU29260" /db_xref="EnsemblGenomes-Tr:CAB14886" /db_xref="GOA:O34922" /db_xref="InterPro:IPR025618" /db_xref="SubtiList:BG13902" /db_xref="UniProtKB/Swiss-Prot:O34922" /translation="MLVLVFLIGLSACFYVYYKVKGVRAKPSLAKEICSAKSSMALGS LVLFYGLNQMILFHSVLTLVIGGIFIVIGAGSAWAGYKAFRHYNPLHAKEAERDHA*" /label="ytpI CDS" gene 2517558..2517860 /gene="ytpI" /locus_tag="BSU_29260" /old_locus_tag="BSU29260" /label="ytpI gene" S_feature 2517861..2519656 /Source="Nicolas_S_feature" /locus_tag="new_2997283_2999078" /HighExp="S8, S6, S7, Lbstat, B36, nit, ferm, T1.0H, C30, S5" /AntisenseName="ytoI" /AntisenseCor="-0.55304378374907204" /AntisenseRegPval="-22.2" /CDS_PredictionProba="0.89152299999999995" /TUshortSig="SigB, SigK, SigA" /TUshortPSig="0.698, 1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1114" CDS complement(2517879..2519198) /gene="ytoI" /locus_tag="BSU_29270" /old_locus_tag="BSU29270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 26296725" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390805.1" /db_xref="EnsemblGenomes-Gn:BSU29270" /db_xref="EnsemblGenomes-Tr:CAB14887" /db_xref="GOA:O34921" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR010766" /db_xref="InterPro:IPR028979" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13897" /db_xref="UniProtKB/Swiss-Prot:O34921" /translation="MATKHEQILTYIDSLPVGEKISVRRIAKEMKVSEGTAYRAIKEA ENKGFVSTIERVGTIRIEQKKKENIEKLTYAEVVNVIDGQVLGGRAGLHKTLNKFVIG AMELDAMMRYTAAGNLLIVGNRINAHRQALEAGAAVLVTGGFNTDDSIVQLADELELP ILSTSYDTFTVAAMINRAIYDQLIKKEIVLVEDILTPADRTVYLSPKDKLEKWYEKNF ETGHGRFPVVDDQMKIHGILTSKDIAGHDRNASIEKVMTKNPVTVIGKTSVASAAQMM VWEGIEVLPVTDGHQKLIGMISRQDVLKALQMIQKQPQVGEKLDDIVSRGFKDEGDDK EDQTVYEYEVTPQMTNQLGTISYGVFTTILTQAANRFLRSKKRGELVIESITIFFLKP VQMESVIEVKPRILEAGRKFGKMEVEVHSQGHIVSKAMLMVQLMERS*" /label="ytoI CDS" gene complement(2517879..2519198) /gene="ytoI" /locus_tag="BSU_29270" /old_locus_tag="BSU29270" /label="ytoI gene" promotor_-10 complement(2519224..2519243) /Source="Nicolas_upshift_promotors" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2519245) /Source="Nicolas_upshifts" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2519258..2519263) /Source="Nicolas_upshift_promotors" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2519374..2520276) /gene="ytnM" /locus_tag="BSU_29280" /old_locus_tag="BSU29280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390806.1" /db_xref="EnsemblGenomes-Gn:BSU29280" /db_xref="EnsemblGenomes-Tr:CAB14888" /db_xref="GOA:O34430" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13894" /db_xref="UniProtKB/Swiss-Prot:O34430" /translation="MKKLIVFAFIGLLSQLIDGSLGMAYGVTSTSLLLAFGITPAVAS ASVHLAEVVTTAASGVSHIKFGNVDKQTVYQLVIPGSIGAFLGAAFLSQLPGDVAKPY ISLFLLLLGGYVLIRFLFQYKPALEKKHVPLNRKQSIPLGVIAGFADATGGGGWGPVT TPILLSRKGLSPRKVVGTVDTSEFAIAVSATAGFLISLGWEDVNWLWVFSLMAGGIIA APIAAWLVQKFHPQLMGVLVGGFIILVNARTLINEWIANTAVHPLIYTAIGAIWLSAV LFVLSKIGNRNIVKTAVDVHLKEK*" /label="ytnM CDS" gene complement(2519374..2520276) /gene="ytnM" /locus_tag="BSU_29280" /old_locus_tag="BSU29280" /label="ytnM gene" CDS complement(2520295..2521545) /gene="sndA" /locus_tag="BSU_29290" /old_locus_tag="BSU29290" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10588044, 10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10588044, 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-alkyl-N-acetyl-metabolite deacetylase" /protein_id="NP_390807.1" /db_xref="EnsemblGenomes-Gn:BSU29290" /db_xref="EnsemblGenomes-Tr:CAB14889" /db_xref="GOA:O34980" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR033846" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12596" /db_xref="UniProtKB/Swiss-Prot:O34980" /translation="MSLDYWRNIEGSYPYQTTGNDILTLKEESNPVNLSTLEKQLIGI RRHLHQYPELSKEEFETTAFIKKCLKEKGIQIRPTALKTGVFADIAGESEGPAIALRA DIDALPIEEKTGLPYASKHKGIMHACGHDFHTAALLGAAFLLKENQDSLKGKIRLLFQ PAEEAGAGATKVIEDGQLDGIDAVIGLHNKPDIAVGTVGLKTGPLMAAVDRFKVEIEG KGAHAALPHNGFDPIIGASQLIVALQTIVSRNVNPLQSAILTVGKINGGSTWNVIPDT VVIEGTVRTFDSEVRNQVKQRFFAVTEQISAAFSLKANVKWHSGPPPLCNDEAITGLV RDAAHKAKLQVIDPAPSTAGEDFAYYLEHIPGSFAFFGTDGDHDWHHPAFTIDETAII KASYFLYESAKRLLDSNEESKISD*" /label="sndA CDS" gene complement(2520295..2521545) /gene="sndA" /locus_tag="BSU_29290" /old_locus_tag="BSU29290" /label="sndA gene" CDS complement(2521563..2522255) /gene="ribR" /locus_tag="BSU_29300" /old_locus_tag="BSU29300" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15668000, 16109943, 17590224, 23944997, 26494285" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15668000, 16109943, 17590224, 23944997, 26494285; Product type r: regulator" /codon_start=1 /transl_table=11 /product="FMN-riboswitch-binding activator of rib genes" /protein_id="NP_390808.1" /db_xref="EnsemblGenomes-Gn:BSU29300" /db_xref="EnsemblGenomes-Tr:CAB14890" /db_xref="GOA:P94465" /db_xref="InterPro:IPR015865" /db_xref="InterPro:IPR023465" /db_xref="InterPro:IPR023468" /db_xref="SubtiList:BG11969" /db_xref="UniProtKB/Swiss-Prot:P94465" /translation="MTIIAGTVVKGKQLGRKLGFPTANVDAKIHGLRNGVYGVLATVN HQFHLGVMNIGVKPTVGSNLEKTLEIFLFDFHRDIYGEKIECSILFKIREERRFDSLE SLTKQIKKDISCVAKRFELIGIMAPNKKESLLSHQELNLPDLCFYKKCNNLYGVNRGV YNVIDNWFFEYGITQVAYRRIYILSFLSFLKEDNPKVSSKYIRFGAGGLADKLNRFIS SYVEESEENILG*" /label="ribR CDS" gene complement(2521563..2522255) /gene="ribR" /locus_tag="BSU_29300" /old_locus_tag="BSU29300" /label="ribR gene" CDS complement(2522302..2523630) /gene="cmoJ" /locus_tag="BSU_29310" /old_locus_tag="BSU29310" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="monooxygenase (S-alkyl substrates)" /protein_id="NP_390809.1" /db_xref="EnsemblGenomes-Gn:BSU29310" /db_xref="EnsemblGenomes-Tr:CAB14891" /db_xref="GOA:O34974" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR016215" /db_xref="InterPro:IPR036661" /db_xref="PDB:1TVL" /db_xref="PDB:1YW1" /db_xref="SubtiList:BG13893" /db_xref="UniProtKB/Swiss-Prot:O34974" /translation="MTRADFIQFGAMIHGVGGTTDGWRHPDVDPSASTNIEFYMKKAQ TAEKGLFSFIFIADGLFISEKSIPHFLNRFEPITILSALASVTKNIGLVGTFSTSFTE PFTISRQLMSLDHISGGRAGWNLVTSPQEGAARNHSKSNLPEHTERYEIAQEHLDVVR GLWNSWEHDAFIHNKKTGQFFDQAKLHRLNHKGKYFQVEGPLNIGRSKQGEPVVFQAG SSETGRQFAAKNADAIFTHSNSLEETKAFYADVKSRAADEGRDPSSVRIFPGISPIVA DTEEEAEKKYREFAELIPIENAVTYLARFFDDYDLSVYPLDEPFPDIGDVGKNAFQST TDRIKREAKARNLTLREVAQEMAFPRTLFIGTPERVASLIETWFNAEAADGFIVGSDI PGTLDAFVEKVIPILQERGLYRQDYRGGTLRENLGLGIPQHQSVLHSSHH*" /label="cmoJ CDS" gene complement(2522302..2523630) /gene="cmoJ" /locus_tag="BSU_29310" /old_locus_tag="BSU29310" /label="cmoJ gene" CDS complement(2523627..2523908) /gene="cmoI" /locus_tag="BSU_29320" /old_locus_tag="BSU29320" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="redoxin" /protein_id="NP_390810.1" /db_xref="EnsemblGenomes-Gn:BSU29320" /db_xref="EnsemblGenomes-Tr:CAB14892" /db_xref="GOA:O34639" /db_xref="InterPro:IPR002109" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13892" /db_xref="UniProtKB/Swiss-Prot:O34639" /translation="MSDVVNIVVWSKKGCSYCEEVKNYLNEKGFPFQNIDVSEKEKLR DILQVKYGVRHVPVVEIGRGNQYQGITEIGIEHLDLALANHAQIKEAKR*" /label="cmoI CDS" gene complement(2523627..2523908) /gene="cmoI" /locus_tag="BSU_29320" /old_locus_tag="BSU29320" /label="cmoI gene" CDS complement(2523923..2524927) /gene="cmoO" /locus_tag="BSU_29330" /old_locus_tag="BSU29330" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9836433, 10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9836433, 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="monooxygenase (S-alkyl substrates)" /protein_id="NP_390811.1" /db_xref="EnsemblGenomes-Gn:BSU29330" /db_xref="EnsemblGenomes-Tr:CAB14893" /db_xref="GOA:O34846" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG13888" /db_xref="UniProtKB/Swiss-Prot:O34846" /translation="MIRLSILDQSLIGEGETAADTLQHTVKLAQMAEECGYHRFWVAE HHNNDEIAGSAPEVLLGYLAASTRKIRLASGGVMLQHYSSYKVAEQFHLLSALAPGRI DLGVGKAPGGFQLSTDALQAEYKKPVRQFDEKLEELTHFVRDDFPDTHRYAALRPRPQ VDRKPGIFLLGGSTESAISAAKLGISFVFAYFINGEEEVLKEARRAFDAHLPPGSEAE FHLAPAVFAAHTKEEAEKHIVSRESIKVVLKDGRKVNVGSREQAEAYLENVTEPYDII VQKTGIIAGTKEEVAEELTRLSGTYKINDFVIFTPIKNAVEKQLSYQLLSDAVLAAKR *" /label="cmoO CDS" gene complement(2523923..2524927) /gene="cmoO" /locus_tag="BSU_29330" /old_locus_tag="BSU29330" /label="cmoO gene" CDS complement(2524924..2525703) /gene="tcyN" /locus_tag="BSU_29340" /old_locus_tag="BSU29340" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino-acid ABC transporter (ATP-binding protein)" /protein_id="NP_390812.1" /db_xref="EnsemblGenomes-Gn:BSU29340" /db_xref="EnsemblGenomes-Tr:CAB14894" /db_xref="GOA:O34900" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG12604" /db_xref="UniProtKB/Swiss-Prot:O34900" /translation="MIEIKNIHKQFGIHHVLKGINLTVRKGEVVTIIGPSGSGKTTFL RCLNLLERPDEGIISIHDKVINCRFPSKKEVHWLRKQTAMVFQQYHLFAHKTVIENVM EGLTIARKMRKQDAYAVAENELRKVGLQDKLNAYPSQLSGGQKQRVGIARALAIHPDV LLFDEPTAALDPELVGEVLEVMLEIVKTGATMIVVTHEMEFARRVSDQVVFMDEGVIV EQGTPEEVFRHTKKDRTRQFLRRVSPEYLFEPKEHIKEPVI*" /label="tcyN CDS" gene complement(2524924..2525703) /gene="tcyN" /locus_tag="BSU_29340" /old_locus_tag="BSU29340" /label="tcyN gene" CDS complement(2525700..2526407) /gene="tcyM" /locus_tag="BSU_29350" /old_locus_tag="BSU29350" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 15849754, 16850406, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 15849754, 16850406, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter (permease)" /protein_id="NP_390813.1" /db_xref="EnsemblGenomes-Gn:BSU29350" /db_xref="EnsemblGenomes-Tr:CAB14895" /db_xref="GOA:O34931" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13887" /db_xref="UniProtKB/Swiss-Prot:O34931" /translation="MQFDFPFIVSAMKEMVKTIPLTLMMAVLPIVFGFLVALGNIIVR IFRIKGLVACSRFYVSFFRSTPAILHIMLIYLGIPPVADQVSSFFHLGWSANEIPVSM FVIMALSLTAGAYLTEIIRSGILAMDTGQVEAAYSIGLTYSQTFRRVILPQALKVSIP NFTNLGIGFLHTTSIAAIVAVPEITGTATIVASDNYAFLEAFIGAAIIYWVLTLILES ANGVLERKAARFQGGTL*" /label="tcyM CDS" gene complement(2525700..2526407) /gene="tcyM" /locus_tag="BSU_29350" /old_locus_tag="BSU29350" /label="tcyM gene" CDS complement(2526437..2527156) /gene="tcyL" /locus_tag="BSU_29360" /old_locus_tag="BSU29360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 15849754, 16850406, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 15849754, 16850406, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter (permease)" /protein_id="NP_390814.1" /db_xref="EnsemblGenomes-Gn:BSU29360" /db_xref="EnsemblGenomes-Tr:CAB14896" /db_xref="GOA:O34315" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13886" /db_xref="UniProtKB/Swiss-Prot:O34315" /translation="MEKAFDMNMIGDFVPTLTAYLPVTLYILTLSLLFGFVLGLFLAL PRIYNIPIVNQLAKVYISFFRGTPIMVQLFIVFYGIPALTGLIGIDTSKMDPFYAAVA TYALSNAAAAAEIIRAGVGSVDKGQTEAAYSIGLSGSQAFRRIVLPQALVQAFPNMGN MVISSLKDTSLAFSIGVMDMSGRGQTLITSSNHSLEVYIALSIVYYAVAVLFEWFFRV AEKRIKKNQTRIVTVFDMNIH*" /label="tcyL CDS" gene complement(2526437..2527156) /gene="tcyL" /locus_tag="BSU_29360" /old_locus_tag="BSU29360" /label="tcyL gene" promotor_-35 2526982..2526989 /Source="Nicolas_upshift_promotors" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2527004..2527023 /Source="Nicolas_upshift_promotors" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2527004 /Source="Nicolas_upshifts" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2527178..2527990) /gene="tcyK" /locus_tag="BSU_29370" /old_locus_tag="BSU29370" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 22720735, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 22720735, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter binding lipoprotein" /protein_id="NP_390815.1" /db_xref="EnsemblGenomes-Gn:BSU29370" /db_xref="EnsemblGenomes-Tr:CAB14897" /db_xref="GOA:O34852" /db_xref="InterPro:IPR001638" /db_xref="PDB:2O1M" /db_xref="SubtiList:BG13885" /db_xref="UniProtKB/Swiss-Prot:O34852" /translation="MKTKTAFMAILFSLITVLSACGAGSQTTGAGQKKVQTITVGTGT QFPNICFIDEKGDLTGYDVELIKELDKRLPHYKFTFKTMEFSNLLVSLGQHKVDIVAH QMEKSKEREKKFLFNKVAYNHFPLKITVLQNNDTIRGIEDLKGKRVITSATSNGALVL KKWNEDNGRPFEIAYEGQGANETANQLKSGRADATISTPFAVDFQNKTSTIKEKTVGN VLSNAKVYFMFNKNEQTLSDDIDKALQEIIDDGTLKRLSLKWLGDDYSKEQY*" /label="tcyK CDS" gene complement(2527178..2527990) /gene="tcyK" /locus_tag="BSU_29370" /old_locus_tag="BSU29370" /label="tcyK gene" CDS complement(2528004..2528813) /gene="tcyJ" /locus_tag="BSU_29380" /old_locus_tag="BSU29380" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sulfur containing amino acid ABC transporter binding lipoprotein" /protein_id="NP_390816.1" /db_xref="EnsemblGenomes-Gn:BSU29380" /db_xref="EnsemblGenomes-Tr:CAB14898" /db_xref="GOA:O34406" /db_xref="InterPro:IPR001638" /db_xref="SubtiList:BG13884" /db_xref="UniProtKB/Swiss-Prot:O34406" /translation="MNKRKGLVLLLSVFALLGGGCSQTNNKTDRQAQTVIVGTGTDFP NIAFLNEKGELTGYDIEVMKAIDKELPQYTFEFKTMDFSNLLTSLGNKKIDVIAHNMA KNKEREKRFLYHKVPYNYSPMYITVKEDNHKIHTLKDLHGKTVIVGATSNAADYITKY NKTHGSPIHLKYAGQGSNDTANQIETGRADATIATPFAVDFQNKTHAFRQKTVGDVLL DTEVYFMFNKGSQTLADDTDQAIKKLEKNGTLKKLSRKWLGADYSKSSFEK*" /label="tcyJ CDS" gene complement(2528004..2528813) /gene="tcyJ" /locus_tag="BSU_29380" /old_locus_tag="BSU29380" /label="tcyJ gene" CDS complement(2528827..2529363) /gene="snaA" /locus_tag="BSU_29390" /old_locus_tag="BSU29390" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyltransferase acting on sulfur compounds" /protein_id="NP_390817.1" /db_xref="EnsemblGenomes-Gn:BSU29390" /db_xref="EnsemblGenomes-Tr:CAB14899" /db_xref="GOA:O34350" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13883" /db_xref="UniProtKB/Swiss-Prot:O34350" /translation="MSDDIFRLATVEDASELLKLVNSAFQPIRQLDIDWPSTRADIQM VSENIEHHSAIVLERDGKLISTITIRFPWESETPPSKYPFVWWFATLPEYKGQGAGSK LLTYVEEKVLRDMLKAPALTLGTSARKHPWLADMYRRRGYEVYFEQEKDGDIGVMMHK VLIPERFNPTLLGAPSWA*" /label="snaA CDS" gene complement(2528827..2529363) /gene="snaA" /locus_tag="BSU_29390" /old_locus_tag="BSU29390" /label="snaA gene" promotor_-35 2529400..2529407 /Source="Nicolas_upshift_promotors" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2529418..2529437) /Source="Nicolas_upshift_promotors" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2529421..2529440 /Source="Nicolas_upshift_promotors" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2529424..2529515 /Source="Nicolas_S_feature" /locus_tag="new_3008846_3008937" /HighExp="dia5, MG 5, UNK1, MG t5, MG 10, B60, dia0, nit, Diami, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1115" upshifts 2529424 /Source="Nicolas_upshifts" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2529434) /Source="Nicolas_upshifts" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2529451..2529458) /Source="Nicolas_upshift_promotors" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2529516..2530442 /gene="ascR" /locus_tag="BSU_29400" /old_locus_tag="BSU29400" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11390694, 11423008, 15272571, 16109943, 16513748, 22212096, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11423008, 15272571, 16109943, 16513748, 22212096, 23944997; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of operon snaA-ytnM degrading cysteine-containing compounds (AscR-N-acetylcysteine)" /protein_id="NP_390818.1" /db_xref="EnsemblGenomes-Gn:BSU29400" /db_xref="EnsemblGenomes-Tr:CAB14900" /db_xref="GOA:O35038" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13877" /db_xref="UniProtKB/Swiss-Prot:O35038" /translation="MELRSIKTFHTIVKFGSFYKAAEILNYSQPTISMRMKQLEQDLG VLLFERGKSLQLTKAGKLFYERTGDLLMQYEALKHNLSDLKEEEAGIINIGVSEPTAS LIFPEILKDFLMDYPKITVNIKVDDANTCSQKLLDGTIDFAVCGEPELILENYYHPFF YDTLNVIVSDQHPLAEKKAVHLSDLAEERFIFTPANCPIRLQIEQHLHRELGNRYKKM ELTSSMSHEYYVRENIGISIFTSTAHSKPFNGTKVIPILNLDITPPIGLLTNQKEVHF DRATKDLIARITKRFQQRSKELEGTSDKTITG*" /label="ascR CDS" gene 2529516..2530442 /gene="ascR" /locus_tag="BSU_29400" /old_locus_tag="BSU29400" /label="ascR gene" S_feature complement(2529918..2530447) /Source="Nicolas_S_feature" /locus_tag="new_3009340_3009869_c" /HighExp="Etha, dia15, dia5, H2O2, M9-stat, M40t90, Sw, Gly, M0t90, Cold" /AntisenseName="ytlI" /AntisenseCor="-7.8012588423369304E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1116" downshifts complement(2530492) /Source="Nicolas_upshifts" /id="D1503" /incds=0 /nref=142 /ntot=251 /MaxReadThrough="4.32965" /MaxDrop="5.01142" /score="39.1547987" /energy="-16.5" /TU="U2273" /idTUdmin="U2274" /TUdmin=20 /isTUend="TRUE" /label="downshifts" CDS complement(2530493..2531176) /gene="ytkL" /locus_tag="BSU_29410" /old_locus_tag="BSU29410" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_390819.2" /db_xref="EnsemblGenomes-Gn:BSU29410" /db_xref="EnsemblGenomes-Tr:CAB14901" /db_xref="GOA:Q795U4" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR022877" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13871" /db_xref="UniProtKB/Swiss-Prot:Q795U4" /translation="MKVTYHGHSVITVETKDHHIIFDPFLTGNSLTDIKPEDVKADVI LLTHGHNDHVGDTEQIAKQNNALVIAPNELAVYLGWKGLNVHPMHIGGSRQFDFGKVK LTQAFHGSAITDEENKTITYTGMPAGILLTVEDKTIFHAGDTALFSDMKLIGELNHID LAFLPIGDNFTMGPEDAKLAAEWLRAKQVVPVHYNTFPVIEQDPEAFADSLPGGVGKV MSVGETIEL*" /label="ytkL CDS" gene complement(2530493..2531176) /gene="ytkL" /locus_tag="BSU_29410" /old_locus_tag="BSU29410" /label="ytkL gene" S_feature complement(2531177..2531238) /Source="Nicolas_S_feature" /locus_tag="new_3010599_3010660_c" /HighExp="dia15, Etha, dia5, Diami, H2O2, M0t90, M40t90, Salt, LBGtran, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1117" CDS complement(2531239..2532006) /gene="ytkK" /locus_tag="BSU_29420" /old_locus_tag="BSU29420" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 3-oxoacyl-acyl-carrier protein reductase" /protein_id="NP_390820.1" /db_xref="EnsemblGenomes-Gn:BSU29420" /db_xref="EnsemblGenomes-Tr:CAB14902" /db_xref="GOA:O34308" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13870" /db_xref="UniProtKB/Swiss-Prot:O34308" /translation="MRHALITAGSKGLGRKVTETLLAKGYSVTVNYRQDEEAVSRLKE ACPDCLDRLQFVKGDVTKKEDLLRIAEAALNRFGRIDFLINNAGPYIFERKKLADYTD DEWYGMLEGNLSAVFHLFKAVIPIMRKQQFGRIITYGFQGAAHAPGWLHRSAFGAAKV GLASLTKTIAIEEAEFGITANMVCPGDIVGDMKEASIEEARMRIGKEKTPIGRSGTGE DIARIIAFLCEENSDLVTGTVIEATGGLNVINKNQTT*" /label="ytkK CDS" gene complement(2531239..2532006) /gene="ytkK" /locus_tag="BSU_29420" /old_locus_tag="BSU29420" /label="ytkK gene" promotor_-10 complement(2532051..2532070) /Source="Nicolas_upshift_promotors" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2532073) /Source="Nicolas_upshifts" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2532086..2532088) /Source="Nicolas_upshift_promotors" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2532133..2532369) /gene="ytzD" /locus_tag="BSU_29430" /old_locus_tag="BSU29430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11423008" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390821.3" /db_xref="EnsemblGenomes-Gn:BSU29430" /db_xref="EnsemblGenomes-Tr:CAB14903" /db_xref="SubtiList:BG13938" /db_xref="UniProtKB/Swiss-Prot:O34503" /translation="MKKRKLAWQQEFVKISFIKSRHYSQPTSIMMGGRMMKKEPERYI YDEQESQETTRLISEAYQSGYVDMPDQESSSPAE*" /label="ytzD CDS" gene complement(2532133..2532369) /gene="ytzD" /locus_tag="BSU_29430" /old_locus_tag="BSU29430" /label="ytzD gene" downshifts 2532218 /Source="Nicolas_upshifts" /id="D1504" /incds=0 /nref=1 /ntot=12 /MaxReadThrough="0.55049" /MaxDrop="4.17437" /score="-5.88070891" /energy="-8.9" /TU="NA" /idTUdmin="U2271" /TUdmin=1782 /isTUend="FALSE" /label="downshifts" downshifts complement(2532238) /Source="Nicolas_upshifts" /id="D1505" /incds=0 /nref=199 /ntot=288 /MaxReadThrough="5.44889" /MaxDrop="6.29233" /score="21.2322542" /energy="-8.5" /TU="U2274" /idTUdmin="U2274" /TUdmin="-1726" /isTUend="FALSE" /label="downshifts" CDS complement(2532329..2533714) /gene="argH" /locus_tag="BSU_29440" /old_locus_tag="BSU29440" /EC_number="4.3.2.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2989674, 9890879, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2989674, 9890879, 11423008; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="argininosuccinate lyase" /protein_id="NP_390822.1" /db_xref="EnsemblGenomes-Gn:BSU29440" /db_xref="EnsemblGenomes-Tr:CAB14904" /db_xref="GOA:O34858" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR009049" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="InterPro:IPR029419" /db_xref="SubtiList:BG12571" /db_xref="UniProtKB/Swiss-Prot:O34858" /translation="MKKLWGGRFQKTPEKWVDEFGASISFDQNLVAEDITGSLAHAAM LKKCGILTAEEELKIREGLNTLLQKAEEGALEFSVDYEDIHLNIEKMLIDEIGPLGGK LHTGRSRNDQVATDMHLYLKNHVGHIIELIEAFQSALIEKAEANVETILPGYTHLQRA QPISFAHHLLAYFWMLERDKERFQDSMKRINKSPLGCGALAGTTFPIDRDYSAELLGF DAIYENSLDGVSDRDFILEFLSNSSMLMMHLSRFSEEIILWCSQEFKFIELDDTYATG SSMMPQKKNPDMAELIRGKTGRVYGDMMGLFTIMKGLPLAYNKDLQEDKEGMFDTVKT VEGSLQIFTGMIQTMTVNKDVMKQATKQDFSNATELADYLAKKGMPFREAHEVVGKLV YTCIERGIYLSDMPFGEFQQASTLFEEDIYTVLDPYYAVEKRMSAGGTGFKQVEQALE KAKACVAAGVC*" /label="argH CDS" gene complement(2532329..2533714) /gene="argH" /locus_tag="BSU_29440" /old_locus_tag="BSU29440" /label="argH gene" CDS complement(2533711..2534922) /gene="argG" /locus_tag="BSU_29450" /old_locus_tag="BSU29450" /EC_number="6.3.4.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2989674, 11423008, 12963366, 17611193" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2989674, 11423008, 12963366, 17611193; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="argininosuccinate synthase" /protein_id="NP_390823.1" /db_xref="EnsemblGenomes-Gn:BSU29450" /db_xref="EnsemblGenomes-Tr:CAB14905" /db_xref="GOA:O34347" /db_xref="InterPro:IPR001518" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR018223" /db_xref="InterPro:IPR023434" /db_xref="InterPro:IPR024074" /db_xref="SubtiList:BG12570" /db_xref="UniProtKB/Swiss-Prot:O34347" /translation="MSEQKKVVLAYSGGLDTSVAIKWLQEQGYNVIACCLDVGEGKDL AFVQQKALEVGATNSYVIDAKEEFAQDYALISLQAHTMYEGKYPLVSALSRPLIAKKL VEIAEKEDAQAIAHGCTGKGNDQVRFEVSIKSLNPDLEVIAPVREWQWSREEEIEYAA SRGIPIPINLDSPYSIDQNLWGRANECGILEDPWAAPPEGAYDLTAPLEKTPDTPEVI EIAFEQGVPVSIDGVSYSLSELILKLNEMAGAHGVGRIDHVENRLVGIKSREVYECPG AMTLIKAHKELEDLTLVKEVAHFKPIIEQKMSEIIYNGLWFSPLKDALHAFLKETQKH VTGIVRVKLFKGHAIVEGRKSEYSLYDEKLATYTKDDAFDHHAAIGFIELWGLPTKVN SIVKKKEQIKA*" /label="argG CDS" gene complement(2533711..2534922) /gene="argG" /locus_tag="BSU_29450" /old_locus_tag="BSU29450" /label="argG gene" S_feature complement(2534923..2535000) /Source="Nicolas_S_feature" /locus_tag="new_3014345_3014422_c" /HighExp="S1, MG 15, T3.0H, T3.30H, T4.0H, T5.0H, BMM, T2.30H, T-0.40H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1118" promotor_-10 complement(2534993..2535012) /Source="Nicolas_upshift_promotors" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2534999) /Source="Nicolas_upshifts" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2535027..2535034) /Source="Nicolas_upshift_promotors" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2535092..2535604) /gene="moaB" /locus_tag="BSU_29460" /old_locus_tag="BSU29460" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15269205, 20054111, 23680484; Product type f: factor" /codon_start=1 /transl_table=11 /product="molybdopterin GTP-binding precursor Z biosynthesis component" /protein_id="NP_390824.1" /db_xref="EnsemblGenomes-Gn:BSU29460" /db_xref="EnsemblGenomes-Tr:CAB14924" /db_xref="GOA:O34457" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR008284" /db_xref="InterPro:IPR012245" /db_xref="InterPro:IPR036425" /db_xref="SubtiList:BG12618" /db_xref="UniProtKB/Swiss-Prot:O34457" /translation="MSVQEHKQEAPDIVRCKVITVSDTRTDETDKSGKLMISFLEEAG HHIAAYEIVKDEKDALQRSVLAGCMDEQTDAVLLNGGTGIADRDVTIEAITPLFSKEL PGFGEIFRMLSYTEDIGSAAIMSRATAGVIQHTAVFSTPGSSGAVKLAMNKLIIPELA HVVREIRKDK*" /label="moaB CDS" gene complement(2535092..2535604) /gene="moaB" /locus_tag="BSU_29460" /old_locus_tag="BSU29460" /label="moaB gene" downshifts complement(2535110) /Source="Nicolas_upshifts" /id="D1506" /incds=0 /nref=122 /ntot=221 /MaxReadThrough="1.48097" /MaxDrop="4.78155" /score="25.7910606" /energy="-10.8" /TU="NA" /idTUdmin="U2275" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2535630..2535649) /Source="Nicolas_upshift_promotors" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2535638) /Source="Nicolas_upshifts" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2535663..2535670) /Source="Nicolas_upshift_promotors" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2535689..2536876) /gene="ackA" /locus_tag="BSU_29470" /old_locus_tag="BSU29470" /EC_number="2.7.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8226682, 9811655, 11244084, 16995897, 19019159, 26098117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8226682, 9811655, 11244084, 16995897, 19019159, 26098117; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="acetate kinase" /protein_id="NP_390825.1" /db_xref="EnsemblGenomes-Gn:BSU29470" /db_xref="EnsemblGenomes-Tr:CAB14925" /db_xref="GOA:P37877" /db_xref="InterPro:IPR000890" /db_xref="InterPro:IPR004372" /db_xref="InterPro:IPR023865" /db_xref="SubtiList:BG10813" /db_xref="UniProtKB/Swiss-Prot:P37877" /translation="MSKIIAINAGSSSLKFQLFEMPSETVLTKGLVERIGIADSVFTI SVNGEKNTEVTDIPDHAVAVKMLLNKLTEFGIIKDLNEIDGIGHRVVHGGEKFSDSVL LTDETIKEIEDISELAPLHNPANIVGIKAFKEVLPNVPAVAVFDTAFHQTMPEQSYLY SLPYEYYEKFGIRKYGFHGTSHKYVTERAAELLGRPLKDLRLISCHLGNGASIAAVEG GKSIDTSMGFTPLAGVAMGTRSGNIDPALIPYIMEKTGQTADEVLNTLNKKSGLLGIS GFSSDLRDIVEATKEGNERAETALEVFASRIHKYIGSYAARMSGVDAIIFTAGIGENS VEVRERVLRGLEFMGVYWDPALNNVRGEEAFISYPHSPVKVMIIPTDEEVMIARDVVR LAK*" /label="ackA CDS" gene complement(2535689..2536876) /gene="ackA" /locus_tag="BSU_29470" /old_locus_tag="BSU29470" /label="ackA gene" downshifts complement(2535704) /Source="Nicolas_upshifts" /id="D1507" /incds=0 /nref=13 /ntot=117 /MaxReadThrough="5.03131" /MaxDrop="3.1641" /score="19.2403206" /energy="-9.9" /TU="U2276" /idTUdmin="U2277" /TUdmin=242 /isTUend="FALSE" /label="downshifts" S_feature complement(2536877..2536981) /Source="Nicolas_S_feature" /locus_tag="new_3016299_3016403_c" /HighExp="dia0, Lbexp, LBGtran, Oxctl, LPh, M0t45, HPh, Paraq, H2O2, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1119" promotor_-10 complement(2536966..2536985) /Source="Nicolas_upshift_promotors" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2536981) /Source="Nicolas_upshifts" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2536983..2537112) /Source="Nicolas_S_feature" /locus_tag="new_3016405_3016534_c" /HighExp="S5, S6, S7, S8, S4, dia5, BT, H2O2, dia15, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1120" promotor_-35 complement(2537001..2537005) /Source="Nicolas_upshift_promotors" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2537049..2537252) /locus_tag="BSU_29479" /old_locus_tag="BSU29479" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513997.1" /translation="MMNGLKKKSKCFKSSLDSRMRSMPKLLLFMLLKTGLDELNPALK HKIQREKPQIVSVHQYKTYSECV*" /label="hypothetical protein CDS" gene complement(2537049..2537252) /locus_tag="BSU_29479" /old_locus_tag="BSU29479" /label="gene" promotor_-10 complement(2537110..2537121) /Source="Nicolas_upshift_promotors" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2537112) /Source="Nicolas_upshifts" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2537136..2537142) /Source="Nicolas_upshift_promotors" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2537224..2538213) /gene="ytxK" /locus_tag="BSU_29480" /old_locus_tag="BSU29480" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleic acid methyltransferase" /protein_id="NP_390826.1" /db_xref="EnsemblGenomes-Gn:BSU29480" /db_xref="EnsemblGenomes-Tr:CAB14926" /db_xref="GOA:P37876" /db_xref="InterPro:IPR003356" /db_xref="InterPro:IPR016843" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10812" /db_xref="UniProtKB/Swiss-Prot:P37876" /translation="MQKDHVGAVYELLNEAAIMIKNELQISYIEALAEAGEMYFLEKT DQLKLPADQKTKQLQALLEKAEFGTYEHEWVRKAFQLAVLKGMKDISHPNRQMTPDTI GLFISYLVNKFMADKKELTILDPALGTGNLLFTVLNQLSEKTANSFGIEIDDVLLKIA YAQANLLKKELELFHQDSLEPLFIDPVDTVICDLPVGYYPNDEGAEAFELKADEGHSF AHHLFIEQSVKHTKPGGYLFFMIPNHLFESSQSGKLKQFFKDKVHINALLQLPKSIFK DEAHAKSILVLQKQGENTKAPGQILLANLPSFSNQKAMLDMMAQFDEWFKKEK*" /label="ytxK CDS" gene complement(2537224..2538213) /gene="ytxK" /locus_tag="BSU_29480" /old_locus_tag="BSU29480" /label="ytxK gene" downshifts complement(2537242) /Source="Nicolas_upshifts" /id="D1508" /incds=0 /nref=158 /ntot=243 /MaxReadThrough="3.51469" /MaxDrop="5.25938" /score="-4.33730173" /energy="-13.3" /TU="NA" /idTUdmin="U2279" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" CDS complement(2538274..2538777) /gene="tpx" /locus_tag="BSU_29490" /old_locus_tag="BSU29490" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12486061, 18588855, 18588855, 23899494, 25355936, 25852656" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486061, 18588855, 18588855, 23899494, 25355936, 25852656; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiol peroxidase (lipid hydroperoxide reductase)" /protein_id="NP_390827.1" /db_xref="EnsemblGenomes-Gn:BSU29490" /db_xref="EnsemblGenomes-Tr:CAB14927" /db_xref="GOA:P80864" /db_xref="InterPro:IPR002065" /db_xref="InterPro:IPR013740" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR018219" /db_xref="InterPro:IPR036249" /db_xref="PDB:2JSY" /db_xref="PDB:2JSZ" /db_xref="SubtiList:BG13855" /db_xref="UniProtKB/Swiss-Prot:P80864" /translation="MAEITFKGGPVTLVGQEVKVGDQAPDFTVLTNSLEEKSLADMKG KVTIISVIPSIDTGVCDAQTRRFNEEAAKLGDVNVYTISADLPFAQARWCGANGIDKV ETLSDHRDMSFGEAFGVYIKELRLLARSVFVLDENGKVVYAEYVSEATNHPNYEKPIE AAKALVK*" /label="tpx CDS" gene complement(2538274..2538777) /gene="tpx" /locus_tag="BSU_29490" /old_locus_tag="BSU29490" /label="tpx gene" downshifts complement(2538280) /Source="Nicolas_upshifts" /id="D1509" /incds=0 /nref=53 /ntot=241 /MaxReadThrough="6.94509" /MaxDrop="4.3179" /score="9.29337297" /energy="-10.1" /TU="U2279" /idTUdmin="U2280" /TUdmin=548 /isTUend="FALSE" /label="downshifts" promotor_no_box 2538494..2538594 /Source="Nicolas_upshift_promotors" /id="U2278" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.924075924075924" /psig="0.001998001998002" /xcortree=44 /SigmaFactorBS="ccgcaccagcgcgcttgcgcgaatggaaggtctgcactgatt gtgtagacgttgacatctccaagctttgcagcttcttcgttaaaacggcgtgtttgtg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2538554 /Source="Nicolas_upshifts" /id="U2278" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.924075924075924" /psig="0.001998001998002" /xcortree=44 /SigmaFactorBS="ccgcaccagcgcgcttgcgcgaatggaaggtctgcactgatt gtgtagacgttgacatctccaagctttgcagcttcttcgttaaaacggcgtgtttgtg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2538773 /Source="Nicolas_upshifts" /id="D1510" /incds=0 /nref=86 /ntot=184 /MaxReadThrough="2.23568" /MaxDrop="5.49495" /score="20.1242958" /energy="-12.7" /TU="NA" /idTUdmin="U2278" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2538800..2538819) /Source="Nicolas_upshift_promotors" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2538816) /Source="Nicolas_upshifts" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2538833..2538840) /Source="Nicolas_upshift_promotors" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2538887..2539342) /gene="gerW" /locus_tag="BSU_29500" /old_locus_tag="BSU29500" /experiment="publication(s) with functional evidences, PMID:23921501, 25790435, 27881417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23921501, 25790435, 27881417; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="germination-associated protein" /protein_id="NP_390828.1" /db_xref="EnsemblGenomes-Gn:BSU29500" /db_xref="EnsemblGenomes-Tr:CAB14928" /db_xref="GOA:O34806" /db_xref="InterPro:IPR014229" /db_xref="SubtiList:BG13849" /db_xref="UniProtKB/Swiss-Prot:O34806" /translation="MADHPIQGLMKTAMENLKEMIDVNTIIGDPVETPDGSVILTVSK VGFGFAAGGSEFGGKPAEKKSEDDETREQKLPFGGGSGGGVSITPIAFLIVGSTGIRM LHLDENTHLIEKILDAAPQTLERIQQMFKKNNKNQSQGQNQNQMNNMNY*" /label="gerW CDS" gene complement(2538887..2539342) /gene="gerW" /locus_tag="BSU_29500" /old_locus_tag="BSU29500" /label="gerW gene" downshifts complement(2538915) /Source="Nicolas_upshifts" /id="D1511" /incds=0 /nref=38 /ntot=91 /MaxReadThrough="3.69502" /MaxDrop="5.65648" /score="26.1939476" /energy="-12.7" /TU="U2280" /idTUdmin="U2280" /TUdmin="-87" /isTUend="FALSE" /label="downshifts" CDS complement(2539356..2540036) /gene="ytfI" /locus_tag="BSU_29510" /old_locus_tag="BSU29510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="conserved sporulation-related protein" /protein_id="NP_390829.1" /db_xref="EnsemblGenomes-Gn:BSU29510" /db_xref="EnsemblGenomes-Tr:CAB14929" /db_xref="InterPro:IPR021338" /db_xref="SubtiList:BG13848" /db_xref="UniProtKB/Swiss-Prot:O34917" /translation="MVYVLTAILILIGIVLLLRMKIHVALEYLHADDNDKLTLKITAL FGLIRIKKTIPAIKVNKEDGTVDIKQKTESKMKKSSGKKKITQNDVQQSINKIEMLLH QVTRLRKISASFLAHLHITKLEWVTVIGIQDAAVTGVLTGAVWGVKGGIAAMLYDHLD FVNKPVYEVIPSFQVPVSKTHFQCIFFFRFGHAMLAAFKFVKYGRELSVLKKNPSARM TSKNDSSV*" /label="ytfI CDS" gene complement(2539356..2540036) /gene="ytfI" /locus_tag="BSU_29510" /old_locus_tag="BSU29510" /label="ytfI gene" upshifts complement(2539448) /Source="Nicolas_upshifts" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="upshifts" promotor_-10 complement(2539455..2539466) /Source="Nicolas_upshift_promotors" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="promotor_-10" promotor_-35 complement(2539481..2539487) /Source="Nicolas_upshift_promotors" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="promotor_-35" downshifts complement(2539774) /Source="Nicolas_upshifts" /id="D1512" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="4.64036" /MaxDrop="2.98792" /score="28.0381876" /energy="-11.8" /TU="U2281" /idTUdmin="U2281" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2540049..2540067) /Source="Nicolas_upshift_promotors" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="promotor_-10" upshifts complement(2540063) /Source="Nicolas_upshifts" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="upshifts" promotor_-35 complement(2540082..2540087) /Source="Nicolas_upshift_promotors" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="promotor_-35" CDS complement(2540111..2540605) /gene="yteJ" /locus_tag="BSU_29520" /old_locus_tag="BSU29520" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23155385; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390830.1" /db_xref="EnsemblGenomes-Gn:BSU29520" /db_xref="EnsemblGenomes-Tr:CAB14930" /db_xref="GOA:O34424" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG13840" /db_xref="UniProtKB/Swiss-Prot:O34424" /translation="MDATYEELERNDIKGPQEAELLTHAYAGFWVRFWAFLLDWLVIW GLNHLLVSPLFTVLDLPKTSGMFTFSAYSVTTLIVYLAYFALMTKYFRQTLGKMVFGL KVVSVKQDSKLTWSTVIFREVVGRYIDKIWILYIVVAFSPTKQGIHDYIADTTVVHEK LYRK*" /label="yteJ CDS" gene complement(2540111..2540605) /gene="yteJ" /locus_tag="BSU_29520" /old_locus_tag="BSU29520" /label="yteJ gene" downshifts complement(2540126) /Source="Nicolas_upshifts" /id="D1513" /incds=0 /nref=240 /ntot=258 /MaxReadThrough="1.43721" /MaxDrop="6.8315" /score="28.0381876" /energy="-11.8" /TU="NA" /idTUdmin="U2282" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2540618..2541625) /gene="sppA" /locus_tag="BSU_29530" /old_locus_tag="BSU29530" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9987136, 10455123, 16484219, 22472423, 23155385, 24228759" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 10455123, 16484219, 22472423, 23155385, 24228759; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="signal peptide peptidase" /protein_id="NP_390831.1" /db_xref="EnsemblGenomes-Gn:BSU29530" /db_xref="EnsemblGenomes-Tr:CAB14931" /db_xref="GOA:O34525" /db_xref="InterPro:IPR002142" /db_xref="InterPro:IPR004635" /db_xref="InterPro:IPR029045" /db_xref="PDB:3RST" /db_xref="PDB:4KWB" /db_xref="SubtiList:BG13839" /db_xref="UniProtKB/Swiss-Prot:O34525" /translation="MNAKRWIALVIALGIFGVSIIVSISMSFFESVKGAQTDLTSLTD ESQEKTLENGSPSSKIAVLEVSGTIQDNGDSSSLLGADGYNHRTFLKNLERAKDDKTV KGIVLKVNSPGGGVYESAEIHKKLEEIKKETKKPIYVSMGSMAASGGYYISTAADKIF ATPETLTGSLGVIMESVNYSKLADKLGISFETIKSGAHKDIMSPSREMTKEEKNIMQS MVDNSYEGFVDVISKGRGMPKAEVKKIADGRVYDGRQAKKLNLVDELGFYDDTITAMK KDHKDLKNASVISYEESFGLGSLFSMGANKMFKSEIDFLNMREILSQSGSPRMMYLYA K*" /label="sppA CDS" gene complement(2540618..2541625) /gene="sppA" /locus_tag="BSU_29530" /old_locus_tag="BSU29530" /label="sppA gene" promotor_-10 complement(2541649..2541664) /Source="Nicolas_upshift_promotors" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2541666) /Source="Nicolas_upshifts" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2541668..2541747) /Source="Nicolas_S_feature" /locus_tag="new_3021090_3021169_c" /HighExp="LBGexp, Oxctl, LBGtran, dia0, H2O2, dia15, G180, G150, Paraq, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1121" promotor_-35 complement(2541676..2541685) /Source="Nicolas_upshift_promotors" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2541725..2541744 /Source="Nicolas_upshift_promotors" /id="U2283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.783216783216783" /psig="0.982017982017982" /xcortree=384 /SigmaFactorBS="aaaatgtttcacttcatgagaaagctccggcttaacgggctg ccggcaaaCGTGGTACACTTATGGCCAAaggtattttatcacaaatactggatggcag a" /listShort="S1122, ppnKB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2541735 /Source="Nicolas_upshifts" /id="U2283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.783216783216783" /psig="0.982017982017982" /xcortree=384 /SigmaFactorBS="aaaatgtttcacttcatgagaaagctccggcttaacgggctg ccggcaaaCGTGGTACACTTATGGCCAAaggtattttatcacaaatactggatggcag a" /listShort="S1122, ppnKB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2541740..2541759) /Source="Nicolas_upshift_promotors" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2541744..2541810 /Source="Nicolas_S_feature" /locus_tag="new_3021166_3021232" /HighExp="M0t90, Sw, M9-stat, BC, M40t90, T4.0H, T2.30H, S1, T3.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1122" upshifts complement(2541747) /Source="Nicolas_upshifts" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2541775..2541779) /Source="Nicolas_upshift_promotors" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2541811..2542614 /gene="ppnKB" /locus_tag="BSU_29540" /old_locus_tag="BSU29540" /EC_number="2.7.1.23" /function="16.7: Manage energy" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12897004, 16233726, 16511117, 25643072; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inorganic polyphosphate/ATP-NAD kinase" /protein_id="NP_390832.1" /db_xref="EnsemblGenomes-Gn:BSU29540" /db_xref="EnsemblGenomes-Tr:CAB14932" /db_xref="GOA:O34934" /db_xref="InterPro:IPR002504" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017437" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13837" /db_xref="UniProtKB/Swiss-Prot:O34934" /translation="MTDQRRNVYFFHKQDQETNEQARSLTQLAEEHGFTVVNQHSDAN IIASIGGDGTFLQAVRKTNFRDDCLYVGITKKGKAHLYCDFHSDEREKMVDAMTFEQI EVRKYPLIEVTVDQASPFHCLNEVSIRSSIIKTFVMDVLIDDLHFETFRGDGMIISTP TGSTAYNKSVAGAVVDPLLPCMQVSELASLNNNTYRTLGSPFVLSSDRKLTLRVVQDG NEHPIIGLDNEALSTRNVKTIEIKLSNKKIKTVKLKDNSFWEKVKRTFL*" /label="ppnKB CDS" gene 2541811..2542614 /gene="ppnKB" /locus_tag="BSU_29540" /old_locus_tag="BSU29540" /label="ppnKB gene" downshifts 2542544 /Source="Nicolas_upshifts" /id="D1514" /incds=1 /nref=46 /ntot=222 /MaxReadThrough="5.39036" /MaxDrop="3.90238" /score="19.2746112" /energy="-13.8" /TU="U2283" /idTUdmin="U2283" /TUdmin="-124" /isTUend="FALSE" /label="downshifts" downshifts 2542602 /Source="Nicolas_upshifts" /id="D1515" /incds=0 /nref=6 /ntot=54 /MaxReadThrough="3.14676" /MaxDrop="4.64552" /score="19.2746112" /energy="-13.8" /TU="U2283" /idTUdmin="U2283" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2542646..2544235) /gene="ytcJ" /locus_tag="BSU_29550" /old_locus_tag="BSU29550" /EC_number="3.5.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19433221, 20386924, 24826896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-substituted formamide deformylase, dihydropyrimidinase or isoaspartyl peptidase" /protein_id="NP_390833.1" /db_xref="EnsemblGenomes-Gn:BSU29550" /db_xref="EnsemblGenomes-Tr:CAB14933" /db_xref="GOA:O34355" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR013108" /db_xref="InterPro:IPR032466" /db_xref="InterPro:IPR033932" /db_xref="SubtiList:BG13835" /db_xref="UniProtKB/Swiss-Prot:O34355" /translation="MKAIWHGGFIYTMLEEGDRTEAVYVEDGVIKGTGSYERLKEKYG SPETEEISLNGAVMFPGFVDSHLHLIGHGEKQLQLDLSALTSKDSILQAAKERERQLP KNDWLIGEGWNENQFETPDYLTKHDLDRLFPDRPVLLKRICRHAIAVNSAALQAAGIS RNTPDPDGGVIVKDANGEPTGLLFDKAQDLILKAVPPVSQHYVDEALTAAIKDCWTKG LTGGHSEDLSYYGDVSVPMKAYEKAAAGGKYPFRCHLLVHHEAVDRWEQLEKLSGPYV EFGAMKIFADGALGGRTALLKEPYQDDPSTNGVQVHDDETLGRLIRKAREKGMEVAVH AIGDLAFEKVLNAIEKHPPKNGRHDRLIHAQVLDNELIERAARMPIALDLQPHFVASD FPWVIDRLGKDRMKTAFAWKTLISKGILCAGGSDAPIEPVDPLLGIQSAVLRKSSHEQ NGPSYNESECLPVYEAIKLYTEGSAGIIYKEKSRGKIAEGYDADFTVLSGDPFAIDPA QLHLLEIKKTVINGQIVYEKS*" /label="ytcJ CDS" gene complement(2542646..2544235) /gene="ytcJ" /locus_tag="BSU_29550" /old_locus_tag="BSU29550" /label="ytcJ gene" downshifts complement(2542655) /Source="Nicolas_upshifts" /id="D1516" /incds=0 /nref=149 /ntot=255 /MaxReadThrough="2.61299" /MaxDrop="5.92403" /score="32.0110789" /energy="-13.8" /TU="NA" /idTUdmin="U2285" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2544255..2545844) /gene="ytcI" /locus_tag="BSU_29560" /old_locus_tag="BSU29560" /EC_number="6.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-coenzyme A synthetase" /protein_id="NP_390834.2" /db_xref="EnsemblGenomes-Gn:BSU29560" /db_xref="EnsemblGenomes-Tr:CAB14934" /db_xref="GOA:C0SPB0" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13834" /db_xref="UniProtKB/Swiss-Prot:C0SPB0" /translation="MLKREDLIAPVQYNLVNEMEKFSAAGQKTALLWEDESGKQESWS YEKLMEETNKIGAALADLGFKKGDKLIVMVPRVLEAYAVYLAILKSGMVVIPCSEMLR AKDLEYRIEHAEVKGAIVYSEFIGAFRDVSTADKLITLSIGENDAGWKNLLSIEADGS QFKTADTTRDDMAFLSYTSGTTGQPKGVVHTHGWAFAHLKTSAGAWLDISEKDIVWAT AAPGWQKWVWSPFLAVLGSGATGFVYHGRFKAEKYLELLNRYKINVFCCTPTEYRLMA KVEGLKRFDLSALHSAVSAGEPLNREVIDVFQKHFGIKVRDGYGQTESTLLVGVLKDT PIKPGSMGKPTPGNQVEIINEDGEICKPGEVGDIAVHLSTPALFKEYFKDPERMKTQI RGDYFLTGDRARKDEEGYFWFESRNDDIIISSGYTIGPFEVEDALVKHPEVKECAVVA SPDEIRGSIVKAYVVLQNHEKRSDELVKMLQNHVKTITAPYKYPREIEFVESLPKTAS AKIRRVELRKREEQLKANKKA*" /label="ytcI CDS" gene complement(2544255..2545844) /gene="ytcI" /locus_tag="BSU_29560" /old_locus_tag="BSU29560" /label="ytcI gene" promotor_-10 complement(2545890..2545907) /Source="Nicolas_upshift_promotors" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2545895) /Source="Nicolas_upshifts" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2545923..2545929) /Source="Nicolas_upshift_promotors" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2546022) /Source="Nicolas_upshifts" /id="D1517" /incds=0 /nref=242 /ntot=266 /MaxReadThrough="2.32229" /MaxDrop="9.17935" /score="30.5720337" /energy="-13.3" /TU="NA" /idTUdmin="U2287" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2546023..2546232) /gene="sspA" /locus_tag="BSU_29570" /old_locus_tag="BSU29570" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:2456528, 2468649, 3009398, 16707666" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2456528, 2468649, 3009398, 16707666; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha-type SASP)" /protein_id="NP_390835.1" /db_xref="EnsemblGenomes-Gn:BSU29570" /db_xref="EnsemblGenomes-Tr:CAB14935" /db_xref="GOA:P04831" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10786" /db_xref="UniProtKB/Swiss-Prot:P04831" /translation="MANNNSGNSNNLLVPGAAQAIDQMKLEIASEFGVNLGADTTSRA NGSVGGEITKRLVSFAQQNMGGGQF*" /label="sspA CDS" gene complement(2546023..2546232) /gene="sspA" /locus_tag="BSU_29570" /old_locus_tag="BSU29570" /label="sspA gene" promotor_-35 2546228..2546232 /Source="Nicolas_upshift_promotors" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2546232 /Source="Nicolas_upshifts" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2546241..2546255 /Source="Nicolas_upshift_promotors" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2546253..2546264) /Source="Nicolas_upshift_promotors" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2546264) /Source="Nicolas_upshifts" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2546279..2546285) /Source="Nicolas_upshift_promotors" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2546326..2547531) /gene="trmG" /locus_tag="BSU_29580" /old_locus_tag="BSU29580" /EC_number="2.8.1.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14757766, 16343540, 22773787, 24705700, 28287455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14757766, 16343540, 22773787, 24705700, 28287455; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="persulfide ATP pyrophosphatase involved in tRNA modification" /protein_id="NP_390836.2" /db_xref="EnsemblGenomes-Gn:BSU29580" /db_xref="EnsemblGenomes-Tr:CAB14936" /db_xref="GOA:O34595" /db_xref="InterPro:IPR003720" /db_xref="InterPro:IPR004114" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR020536" /db_xref="SubtiList:BG13827" /db_xref="UniProtKB/Swiss-Prot:O34595" /translation="MNYDHILIRFGEISTKGKNRKSFIERLKQNIRLVLKDYPNLKYF SNRDRMTITLNGEDPEALFPHLKQVFGIQSFSLAIKCDSRLDDIKATALKAIKDQYKP GDTFKVATKRAYKQFELDTNQMNAEIGGHILRNTEGLTVDVRNPDIPLRIEIREEATF LTIRDEKGAGGLPVGSAGKAMLMLSGGFDSPVAGFYAMKRGLSVEAVHFFSPPYTSER AKQKVMDLAKCLSRFGGSMTLHIVPFTKTQELIQKQIPENYTMTATRRLMLQIADRIR EKRNGLAIITGESLGQVASQTLESMYAINAVTSTPILRPLIAMDKTEIIEKSREIGTY ETSIQPFEDCCTIFTPPSPKTRPKKEKIEHFESFVDFEPYIQEAVDNIETMTLYSEQE ANDKFAELF*" /label="trmG CDS" gene complement(2546326..2547531) /gene="trmG" /locus_tag="BSU_29580" /old_locus_tag="BSU29580" /label="trmG gene" CDS complement(2547535..2548680) /gene="iscSB" /locus_tag="BSU_29590" /old_locus_tag="BSU29590" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11443125, 13129955, 14757766, 16388576, 17237162, 14567704, 22773787, 28882201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11443125, 13129955, 14757766, 16388576, 17237162, 14567704, 22773787, 28882201; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase" /protein_id="NP_390837.1" /db_xref="EnsemblGenomes-Gn:BSU29590" /db_xref="EnsemblGenomes-Tr:CAB14937" /db_xref="GOA:O34874" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="SubtiList:BG12632" /db_xref="UniProtKB/Swiss-Prot:O34874" /translation="MIYLDNSSTTKPYDEVLNVYEQTSSRYFGNPSSLHRYGAETEQL LQAAKNQIKRSLGLKKYDIVFTSGATEANNAALKGAALSKIKTGKHIIATSIEHPSVT ESLEQLKELFGFDITYLSVNEDGFVSIEDLKAAIRPDTVLVSMMHVNNEVGSVQPIEA AGEVLKEHSNILFHVDYVQGIYKVPLAIEKAGIDLCSISGHKFHGLKGTGALIVKEGT RLIPLITGGSQQKGIRAGTEHTAGAVSLAKAINLASADFDTRLDTMTAVKELFMNRLS EIEGVVINTPQMNSAPHIINFSVPGIKAEVLLHMLEEQDIFVSTTSACSAKEHKPSKV LLEMGKGEQIAGSSIRISLNYSQTSDVAEPFMNALRPGIKKLREMMR*" /label="iscSB CDS" gene complement(2547535..2548680) /gene="iscSB" /locus_tag="BSU_29590" /old_locus_tag="BSU29590" /label="iscSB gene" S_feature complement(2548681..2549824) /Source="Nicolas_S_feature" /locus_tag="new_3028103_3029246_c" /HighExp="Diami, dia15, dia5, H2O2, G135, G180, G150, C30, Paraq, LBGstat" /AntisenseName="braB" /AntisenseCor="0.41502288403214899" /AntisenseRegPval="-11.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1123" promotor_-35 2548767..2548774 /Source="Nicolas_upshift_promotors" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2548785..2548874 /Source="Nicolas_S_feature" /locus_tag="new_3028207_3028296" /HighExp="LPh, HPh, BMM, dia0, Heat, G180, Cold, LBGexp, C30, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1124" upshifts 2548785 /Source="Nicolas_upshifts" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2548787..2548806 /Source="Nicolas_upshift_promotors" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2548875..2550212 /gene="braB" /locus_tag="BSU_29600" /old_locus_tag="BSU29600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11528000, 15849754, 16850406, 26473603" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11528000, 15849754, 16850406, 26473603; Product type t: transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid-Na+ symporter" /protein_id="NP_390838.1" /db_xref="EnsemblGenomes-Gn:BSU29600" /db_xref="EnsemblGenomes-Tr:CAB14938" /db_xref="GOA:O34545" /db_xref="InterPro:IPR004685" /db_xref="SubtiList:BG12573" /db_xref="UniProtKB/Swiss-Prot:O34545" /translation="MKHSLPVKDTIIIGFMLFALFFGAGNMIYPPELGQAAGHNVWKA IGGFLLTGVGLPLLGIIAIALTGKDAKGLADKAHPVFGTIFTVVLYLSIGPLFAIPRT GTVSYEIGAVPFLTGVPERLSLLIFTLIFFGVTYYLALNPSKVVDRVGKILTPIKFTI ILIIVLKAIFTPMGGLGAVTEAYKGTPVFKGFLEGYKTMDALASIVFGVVVVNAVKSK GVTQSKALAAACIKAGVIAALGLTFIYVSLAYLGATSTNAIGPVGEGAKILSASSHYL FGSLGNIVLGAAITVACLTTSIGLVTSCGQYFSKLIPALSYKIVVTIVTLFSLIIANF GLAQIIAFSVPILSAIYPLAIVIIVLSFIDKIFKERREVYIACLIGTGLFSILDGIKA AGFSLGSLDVFLNANLPLYSLGIGWVLPGIVGAVIGYVLTLFIGPSKQLNEIS*" /label="braB CDS" gene 2548875..2550212 /gene="braB" /locus_tag="BSU_29600" /old_locus_tag="BSU29600" /label="braB gene" promotor_-10 complement(2549810..2549829) /Source="Nicolas_upshift_promotors" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2549824) /Source="Nicolas_upshifts" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2549844..2549851) /Source="Nicolas_upshift_promotors" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2550188 /Source="Nicolas_upshifts" /id="D1518" /incds=0 /nref=69 /ntot=174 /MaxReadThrough="1.86149" /MaxDrop="6.26921" /score="14.5905051" /energy="-15.2" /TU="U2288" /idTUdmin="U2288" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2550307..2551995) /gene="ezrA" /locus_tag="BSU_29610" /old_locus_tag="BSU29610" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10449747, 15101985, 15317798, 16549676, 17718511, 17873055, 18363795, 19429628, 21401734, 24218584, 25954268, 28357277" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10449747, 15101985, 15317798, 16549676, 17718511, 17873055, 18363795, 19429628, 21401734, 24218584, 25954268, 28357277; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of FtsZ ring formation" /protein_id="NP_390839.1" /db_xref="EnsemblGenomes-Gn:BSU29610" /db_xref="EnsemblGenomes-Tr:CAB14939" /db_xref="GOA:O34894" /db_xref="InterPro:IPR010379" /db_xref="PDB:4UXV" /db_xref="SubtiList:BG13934" /db_xref="UniProtKB/Swiss-Prot:O34894" /translation="MEFVIGLLIVLLALFAAGYFFRKKIYAEIDRLESWKIEILNRSI VEEMSKIKHLKMTGQTEEFFEKWREEWDEIVTAHMPKVEELLYDAEENADKYRFKKAN QVLVHIDDLLTAAESSIEKILREISDLVTSEEKSREEIEQVRERYSKSRKNLLAYSHL YGELYDSLEKDLDEIWSGIKQFEEETEGGNYITARKVLLEQDRNLERLQSYIDDVPKL LADCKQTVPGQIAKLKDGYGEMKEKGYKLEHIQLDKELENLSNQLKRAEHVLMTELDI DEASAILQLIDENIQSVYQQLEGEVEAGQSVLSKMPELIIAYDKLKEEKEHTKAETEL VKESYRLTAGELGKQQAFEKRLDEIGKLLSSVKDKLDAEHVAYSLLVEEVASIEKQIE EVKKEHAEYRENLQALRKEELQARETLSNLKKTISETARLLKTSNIPGIPSHIQEMLE NAHHHIQETVNQLNELPLNMEEAGAHLKQAEDIVNRASRESEELVEQVILIEKIIQFG NRFRSQNHILSEQLKEAERRFYAFDYDDSYEIAAAAVEKAAPGAVEKIKADISA*" /label="ezrA CDS" gene complement(2550307..2551995) /gene="ezrA" /locus_tag="BSU_29610" /old_locus_tag="BSU29610" /label="ezrA gene" downshifts complement(2550308) /Source="Nicolas_upshifts" /id="D1519" /incds=0 /nref=224 /ntot=257 /MaxReadThrough="3.34218" /MaxDrop="5.3305" /score="9.25784495" /energy="-8.6" /TU="U2290" /idTUdmin="U2290" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(2551996..2552101) /Source="Nicolas_S_feature" /locus_tag="new_3031418_3031523_c" /HighExp="C90, Lbtran, BMM, LBGtran, MG 150, S1, Lbexp, dia0, LBGexp, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1125" promotor_-35 2552078..2552086 /Source="Nicolas_upshift_promotors" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2552089..2552108) /Source="Nicolas_upshift_promotors" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2552097..2552116 /Source="Nicolas_upshift_promotors" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2552101) /Source="Nicolas_upshifts" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="upshifts" upshifts 2552101 /Source="Nicolas_upshifts" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" S_feature 2552102..2552191 /Source="Nicolas_S_feature" /locus_tag="new_3031524_3031613" /HighExp="HiOs, C90, dia5, T-5.40H, S1, T-3.40H, GM-0.1, GM 15, T3.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1126" S_feature complement(2552103..2552662) /Source="Nicolas_S_feature" /locus_tag="new_3031525_3032084_c" /HighExp="Etha, Salt, Cold, G135, Lbstat, G180, G150, H2O2, Heat, Paraq" /AntisenseName="hisJ" /AntisenseCor="0.37018688255337001" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1127" promotor_-35 complement(2552124..2552126) /Source="Nicolas_upshift_promotors" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2552192..2552998 /gene="hisK" /locus_tag="BSU_29620" /old_locus_tag="BSU29620" /EC_number="3.1.3.15" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10322033" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10322033; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol phosphate phosphatase" /protein_id="NP_390840.1" /db_xref="EnsemblGenomes-Gn:BSU29620" /db_xref="EnsemblGenomes-Tr:CAB14940" /db_xref="GOA:O34411" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR010140" /db_xref="InterPro:IPR016195" /db_xref="SubtiList:BG13931" /db_xref="UniProtKB/Swiss-Prot:O34411" /translation="MQKRDGHIHTPFCPHGSNDTLRQYAEEALKKGFESITFTEHAPL PPSFTDPTPLKDSAMAQASLERYIHEISGLKKEYRGQLSIRTGLEVDYIAEFEDEITL FLDTYGPYLDDSILSVHFLRTDSSYLCLDYDEHTFKELISACGSIEAVYEQYYRSIYS SIVASLGVYKPKRVGHITLVQKFIKLFPYSMSEHIRGLVSLCLNAIEENGMELDFNTS GLRKTYAGGIYIEDWMLNEAKQKKIPLVFGSDAHQAGDVGYAYEAFLERC*" /label="hisK CDS" gene 2552192..2552998 /gene="hisK" /locus_tag="BSU_29620" /old_locus_tag="BSU29620" /label="hisK gene" promotor_-10 complement(2552666..2552685) /Source="Nicolas_upshift_promotors" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2552679) /Source="Nicolas_upshifts" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2552697..2552704) /Source="Nicolas_upshift_promotors" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2552948..2552994) /Source="Nicolas_S_feature" /locus_tag="new_3032370_3032416_c" /HighExp="M9-stat, T5.0H, LoTm, T4.0H, S2, BC, T3.30H, S4, T3.0H, B60" /AntisenseName="hisJ" /AntisenseCor="-0.46006853678527698" /AntisenseRegPval="-14.8" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1128" downshifts complement(2552970) /Source="Nicolas_upshifts" /id="D1520" /incds=0 /nref=51 /ntot=97 /MaxReadThrough="1.55523" /MaxDrop="6.84653" /score="-4.34170655" /energy="-10.5" /TU="NA" /idTUdmin="U2296" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2552995..2553618) /gene="refZ" /locus_tag="BSU_29630" /old_locus_tag="BSU29630" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11988534, 22730127, 26360512" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11988534, 22730127, 26360512; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of FtsZ defining the chromosome regioncaptured in the forespore" /protein_id="NP_390841.1" /db_xref="EnsemblGenomes-Gn:BSU29630" /db_xref="EnsemblGenomes-Tr:CAB14941" /db_xref="GOA:O34970" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG13927" /db_xref="UniProtKB/Swiss-Prot:O34970" /translation="MKVSTKDKIIESAVMLFNQKGFSGTSVREIAKSADVNVAHISYY FKGKGGLMEHLVSEFYEGYSKTLETAASNISTQSTQEQLLQLVFDILSYQHNHRQLTR FVYREVTIDSTLIREIMSTYLMKEKYIFQLIIEEGEKQREYLTLPLPHFILQLKSLLM MPYLQPQYISEVLYMQPHEPYFYKMYFEEIKIWIRSVFRTGDVALTN*" /label="refZ CDS" gene complement(2552995..2553618) /gene="refZ" /locus_tag="BSU_29630" /old_locus_tag="BSU29630" /label="refZ gene" S_feature 2552999..2553341 /Source="Nicolas_S_feature" /locus_tag="new_3032421_3032763" /HighExp="C90, HiOs, Sw, dia5, GM-0.1, S1, MG 5, UNK1, MG 60, MG t5" /AntisenseName="yttP" /AntisenseCor="-0.79169109805002003" /AntisenseRegPval="-58.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1129" promotor_-35 2553319..2553326 /Source="Nicolas_upshift_promotors" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2553341..2553360 /Source="Nicolas_upshift_promotors" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2553343..2553486 /Source="Nicolas_S_feature" /locus_tag="new_3032765_3032908" /HighExp="Diami, dia15, dia5, H2O2, C90, Paraq, Salt, Etha, Oxctl, Sw" /AntisenseName="yttP" /AntisenseCor="-0.81457903975257295" /AntisenseRegPval="-64.400000000000006" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1130" upshifts 2553343 /Source="Nicolas_upshifts" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2553458..2553462 /Source="Nicolas_upshift_promotors" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2553478..2553497 /Source="Nicolas_upshift_promotors" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2553488..2553618 /Source="Nicolas_S_feature" /locus_tag="new_3032910_3033040" /HighExp="Diami, dia15, dia5, H2O2, Paraq, C90, HPh, LBGexp, Oxctl, Sw" /AntisenseName="yttP" /AntisenseCor="-0.82273476313537297" /AntisenseRegPval="-66.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.982, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1131" upshifts 2553488 /Source="Nicolas_upshifts" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" S_feature 2553620..2553744 /Source="Nicolas_S_feature" /locus_tag="new_3033042_3033166" /HighExp="Diami, dia5, dia15, H2O2, C90, BC, HiOs, Paraq, Sw, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.598, 0.982, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1132" upshifts 2553620 /Source="Nicolas_upshifts" /id="U2295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.582417582417582" /psig="0.598401598401598" /xcortree=570 /SigmaFactorBS="ttttggttaaaaagcatgacagcagattcaataattttgtct ttggtgcttactttcatacggctcactccttcctCTTGATACTATTCAAGCAGAaagc c" /listShort="S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2553634..2553652) /Source="Nicolas_upshift_promotors" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2553636..2553655 /Source="Nicolas_upshift_promotors" /id="U2295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.582417582417582" /psig="0.598401598401598" /xcortree=570 /SigmaFactorBS="ttttggttaaaaagcatgacagcagattcaataattttgtct ttggtgcttactttcatacggctcactccttcctCTTGATACTATTCAAGCAGAaagc c" /listShort="S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2553652) /Source="Nicolas_upshifts" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2553663..2553671) /Source="Nicolas_upshift_promotors" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2553745..2554236 /gene="msrC" /locus_tag="BSU_29640" /old_locus_tag="BSU29640" /EC_number="1.8.4.14" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17535911, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="free methionine-(R)-sulfoxide reductase" /protein_id="NP_390842.2" /db_xref="EnsemblGenomes-Gn:BSU29640" /db_xref="EnsemblGenomes-Tr:CAB14942" /db_xref="InterPro:IPR000614" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG13923" /db_xref="UniProtKB/Swiss-Prot:O34553" /translation="MFHVEKQSGDKEKDYQLLLKQLEAMTEDETDQIANYANASALLY HSLPEVNWAGFYFAKEEDGQLVLGPFQGLPACVRIPFGRGVCGTAYANGKVERIEDVN AFPGHIACDAASQSEIVLPIRVDGKIVGVLDIDSPVKNRFDEIDEKYLTQFAETLEKA LAQ*" /label="msrC CDS" gene 2553745..2554236 /gene="msrC" /locus_tag="BSU_29640" /old_locus_tag="BSU29640" /label="msrC gene" downshifts 2554215 /Source="Nicolas_upshifts" /id="D1521" /incds=0 /nref=72 /ntot=213 /MaxReadThrough="3.66093" /MaxDrop="6.50628" /score="34.0123402" /energy="-11.9" /TU="U2291,U2293,U2294" /idTUdmin="U2295" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2554274..2556013) /gene="dgcP" /locus_tag="BSU_29650" /old_locus_tag="BSU29650" /EC_number="2.7.7.65" /function="16.12: Sense" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23893111" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="NP_390843.1" /db_xref="EnsemblGenomes-Gn:BSU29650" /db_xref="EnsemblGenomes-Tr:CAB14943" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG13918" /db_xref="UniProtKB/Swiss-Prot:O34325" /translation="MVEQTKDQLSAFHYHMLDFLLTKSEKVTFTDSFIWLTSAIQTYF STLCVSLTPSPSDFVTKLADGEARFSASKINASCYLIEDGSGRRFHLACRQDEEIPEG LPDVVASFLNQSMKQERLYNKTIYQKKIYKMTELFHSLLDQTDVLKQLLESLTSTFSL FEFSLFISHDQDQCLGIPAKELYMEGEKSDSFALKVYLSGDILRKNESVAYIPIKGQQ GTYGVLKAEGTGDSFLTDACLDEMSLLANAAGKAFENAQLYEQSKASIANLELINETS RRLNQRLTLTDTMNDLAVRMAESFQAEEVGFFHIDHFENLTLLPGSTAFFKEAKPSDF YNELKEKLYEGEKGVFIGNGQSVFGKAGYGSLMAAPMIQNDRLLGFAVLLKQELYAFT FEMYKLFQALIHHATLAVTNSMLRDRLEHLVKTDQLTELYSRAYLDEKIQYSMKIHQK GVFILVDIDNFKNVNDTYGHQTGDEILIQVASVIKSNIRKHDVGARWGGEELAIYLPN VPVAVGKRITERLVYAVRKNTKPEVTISCGISCWTTETKKSLKELVHEADEALYSAKR SGKNRLMIHDSIK*" /label="dgcP CDS" gene complement(2554274..2556013) /gene="dgcP" /locus_tag="BSU_29650" /old_locus_tag="BSU29650" /label="dgcP gene" downshifts complement(2554292) /Source="Nicolas_upshifts" /id="D1522" /incds=0 /nref=23 /ntot=178 /MaxReadThrough="3.68958" /MaxDrop="4.52201" /score="-0.637788006" /energy="-11.9" /TU="U2298" /idTUdmin="U2298" /TUdmin="-45" /isTUend="FALSE" /label="downshifts" promotor_-35 2555487..2555494 /Source="Nicolas_upshift_promotors" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="promotor_-35" promotor_-10 2555508..2555526 /Source="Nicolas_upshift_promotors" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="promotor_-10" upshifts 2555511 /Source="Nicolas_upshifts" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="upshifts" S_feature 2555513..2556108 /Source="Nicolas_S_feature" /locus_tag="new_3034935_3035530" /HighExp="Cold, LBGstat, C30, Lbstat, GM 25, GM 10, GM 120, GM-0.1, GM 5, GM-0.2" /AntisenseName="ytrP" /AntisenseCor="-0.113221814489707" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1133" misc_feature complement(2556043..2556062) /Source="Nicolas_upshift_promotors" /id="U2298" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig="0.999000999001" /xcortree=428 /SigmaFactorBS="aatttatttgttttgaagtcaaccattcctccattattgctt caccgttTATGATATAATAAACAAAAAttagtggtaaacttttaggtgataaaaacat g" /listShort="ytrP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2556051) /Source="Nicolas_upshifts" /id="U2298" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig="0.999000999001" /xcortree=428 /SigmaFactorBS="aatttatttgttttgaagtcaaccattcctccattattgctt caccgttTATGATATAATAAACAAAAAttagtggtaaacttttaggtgataaaaacat g" /listShort="ytrP" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2556053..2556886) /Source="Nicolas_S_feature" /locus_tag="new_3035475_3036308_c" /HighExp="Etha, S7, Gly, S8, M9-stat, Sw, G135, S6, BC, C30" /AntisenseName="rpsD" /AntisenseCor="-0.48019282175486899" /AntisenseRegPval="-16.2" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S1134" promotor_-35 2556089..2556096 /Source="Nicolas_upshift_promotors" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2556110..2556307 /Source="Nicolas_S_feature" /locus_tag="new_3035532_3035729" /HighExp="UNK1, Cold, HPh, C30, aero, LPhT, MG 25, Oxctl, Heat, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.139124" /TUshortSig="SigA, SigD" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1135" promotor_-10 2556110..2556129 /Source="Nicolas_upshift_promotors" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2556110 /Source="Nicolas_upshifts" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 2556167..2556299 /gene="ldsD" /locus_tag="BSU_misc_RNA_93" /product="ribosomal protein S4 leader mRNA sequence" /experiment="publication(s) with functional evidences, PMID:23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23611891" /label="ldsD RNA" gene 2556167..2556299 /gene="ldsD" /locus_tag="BSU_misc_RNA_93" /label="ldsD gene" CDS 2556308..2556910 /gene="rpsD" /locus_tag="BSU_29660" /old_locus_tag="BSU29660" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1400226, 1699930, 1906866, 12682299, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1400226, 1699930, 1906866, 12682299, 23611891; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S4 (BS4)" /protein_id="NP_390844.1" /db_xref="EnsemblGenomes-Gn:BSU29660" /db_xref="EnsemblGenomes-Tr:CAB14944" /db_xref="GOA:P21466" /db_xref="InterPro:IPR001912" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR005709" /db_xref="InterPro:IPR018079" /db_xref="InterPro:IPR022801" /db_xref="InterPro:IPR036986" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10372" /db_xref="UniProtKB/Swiss-Prot:P21466" /translation="MARYTGPSWKLSRRLGISLSGTGKELEKRPYAPGPHGPGQRKKL SEYGLQLQEKQKLRHMYGVNERQFRTLFDKAGKLAGKHGENFMILLDSRLDNVVYKLG LARTRRQARQLVNHGHILVDGSRVDIPSYLVKPGQTIGVREKSRNLSIIKESVEVNNF VPEYLTFDAEKLEGTFTRLPERSELAPEINEALIVEFYSR*" /label="rpsD CDS" gene 2556308..2556910 /gene="rpsD" /locus_tag="BSU_29660" /old_locus_tag="BSU29660" /label="rpsD gene" downshifts 2556833 /Source="Nicolas_upshifts" /id="D1523" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="8.1141" /MaxDrop="2.9392" /score="31.6842" /energy="-13.6" /TU="U2297,U2299" /idTUdmin="U2297" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" S_feature complement(2556888..2557107) /Source="Nicolas_S_feature" /locus_tag="new_3036310_3036529_c" /HighExp="S5, Etha, S8, S6, S7, S4, BT, S3, M9-stat, B36" /AntisenseName="rpsD" /AntisenseCor="-0.59018291599064199" /AntisenseRegPval="-25.9" /CDS_PredictionProba="0.99997899999999995" /TUshortSig="SigB" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S1136" downshifts 2556896 /Source="Nicolas_upshifts" /id="D1524" /incds=0 /nref=135 /ntot=252 /MaxReadThrough="5.6866" /MaxDrop="6.10502" /score="31.6842" /energy="-13.6" /TU="U2299" /idTUdmin="U2297" /TUdmin=19 /isTUend="TRUE" /label="downshifts" downshifts complement(2556931) /Source="Nicolas_upshifts" /id="D1525" /incds=0 /nref=1 /ntot=23 /MaxReadThrough="4.84346" /MaxDrop="3.28594" /score="-4.07107651" /energy="-10.8" /TU="U2300" /idTUdmin="U2301" /TUdmin=264 /isTUend="FALSE" /label="downshifts" downshifts 2556943 /Source="Nicolas_upshifts" /id="D1526" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="5.7799" /MaxDrop="4.26349" /score="31.6842" /energy="-13.6" /TU="U2299" /idTUdmin="U2297" /TUdmin=66 /isTUend="FALSE" /label="downshifts" S_feature 2556988..2557161 /Source="Nicolas_S_feature" /locus_tag="new_3036410_3036583" /HighExp="LBGtran, LoTm, C30, Cold, LBGexp, B60, dia15, B36, H2O2, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD" /TUlongPSig=1 /label="S1137" promotor_-10 complement(2557103..2557121) /Source="Nicolas_upshift_promotors" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2557115) /Source="Nicolas_upshifts" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="upshifts" downshifts 2557119 /Source="Nicolas_upshifts" /id="D1527" /incds=0 /nref=7 /ntot=151 /MaxReadThrough="1.39547" /MaxDrop="6.12149" /score="26.4940291" /energy="-16.4" /TU="NA" /idTUdmin="U2299" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(2557136..2557142) /Source="Nicolas_upshift_promotors" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2557181..2558449) /gene="tyrS" /locus_tag="BSU_29670" /old_locus_tag="BSU29670" /EC_number="6.1.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12547201, 15879350, 1735721, 9098057" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12547201, 15879350, 1735721, 9098057; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tyrosyl-tRNA synthetase" /protein_id="NP_390845.1" /db_xref="EnsemblGenomes-Gn:BSU29670" /db_xref="EnsemblGenomes-Tr:CAB14945" /db_xref="GOA:P22326" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002307" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024088" /db_xref="InterPro:IPR024107" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10371" /db_xref="UniProtKB/Swiss-Prot:P22326" /translation="MTNLLEDLSFRGLIQQMTDEEGLNKQLNEEKIRLYSGFDPTADS LHIGHLLPILTLRRFQLAGHHPIALVGGATGLIGDPSGKKAERTLNTADIVSEWSQKI KNQLSRFLDFEAAENPAVIANNFDWIGKMNVIDFLRDVGKNFGINYMLAKDTVSSRIE SGISYTEFSYMILQSYDFLNLYRDKNCKLQIGGSDQWGNITAGLELIRKSEEEGAKAF GLTIPLVTKADGTKFGKTEGGAIWLDKEKTSPYEFYQFWINTDDRDVVKYLKYFTFLS KEEIEAYAEKTETAPEKREAQKRLAEEVTSLVHGREALEQAINISQALFSGNIKELSA QDVKVGFKDVPSMEVDSTQELSLVDVLVQSKLSPSKRQAREDIQNGAVYINGERQTEI NYTLSGEDRIENQFTVLRRGKKKYFLVTYK*" /label="tyrS CDS" gene complement(2557181..2558449) /gene="tyrS" /locus_tag="BSU_29670" /old_locus_tag="BSU29670" /label="tyrS gene" downshifts complement(2557207) /Source="Nicolas_upshifts" /id="D1528" /incds=0 /nref=110 /ntot=357 /MaxReadThrough="2.2673" /MaxDrop="6.847" /score="22.5238672" /energy="-16.4" /TU="NA" /idTUdmin="U2301" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" misc_RNA complement(2558473..2558746) /gene="tboY" /locus_tag="BSU_misc_RNA_83" /product="T-Box riboswitch specific of tyrosine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:8045882, 10943892, 1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 10943892, 1317842, 9098041, 12165569, 12547201; Product type n : RNA" /function="16.3: Control" /label="tboY RNA" gene complement(2558473..2558746) /gene="tboY" /locus_tag="BSU_misc_RNA_83" /label="tboY gene" S_feature complement(2558494..2558637) /Source="Nicolas_S_feature" /locus_tag="new_3037916_3038059_c" /HighExp="B60, Sw, B36, BC, M9-stat, T1.30H, S4, T4.0H, T2.30H, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40126600000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1138" downshifts complement(2558537) /Source="Nicolas_upshifts" /id="D1529" /incds=0 /nref=58 /ntot=127 /MaxReadThrough="6.75235" /MaxDrop="6.49727" /score="45.7279775" /energy="-17.7" /TU="U2301,U2303" /idTUdmin="U2301" /TUdmin="-1342" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2558744..2558763) /Source="Nicolas_upshift_promotors" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2558756) /Source="Nicolas_upshifts" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2558776..2558783) /Source="Nicolas_upshift_promotors" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2558791..2560509) /gene="acsA" /locus_tag="BSU_29680" /old_locus_tag="BSU29680" /EC_number="6.2.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7934817, 10986270, 11255012, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10986270, 11255012, 16855235, 18487328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA synthetase" /protein_id="NP_390846.1" /db_xref="EnsemblGenomes-Gn:BSU29680" /db_xref="EnsemblGenomes-Tr:CAB14946" /db_xref="GOA:P39062" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG10370" /db_xref="UniProtKB/Swiss-Prot:P39062" /translation="MNLKALPAIEGDHNLKNYEETYRHFDWAEAEKHFSWHETGKLNA AYEAIDRHAESFRKNKVALYYKDAKRDEKYTFKEMKEESNRAGNVLRRYGNVEKGDRV FIFMPRSPELYFIMLGAIKIGAIAGPLFEAFMEGAVKDRLENSEAKVVVTTPELLERI PVDKLPHLQHVFVVGGEAESGTNIINYDEAAKQESTRLDIEWMDKKDGFLLHYTSGST GTPKGVLHVHEAMIQQYQTGKWVLDLKEEDIYWCTADPGWVTGTVYGIFAPWLNGATN VIVGGRFSPESWYGTIEQLGVNVWYSAPTAFRMLMGAGDEMAAKYDLTSLRHVLSVGE PLNPEVIRWGHKVFNKRIHDTWWMTETGSQLICNYPCMDIKPGSMGKPIPGVEAAIVD NQGNELPPYRMGNLAIKKGWPSMMHTIWNNPEKYESYFMPGGWYVSGDSAYMDEEGYF WFQGRVDDVIMTSGERVGPFEVESKLVEHPAIAEAGVIGKPDPVRGEIIKAFIALREG FEPSDKLKEEIRLFVKQGLAAHAAPREIEFKDKLPKTRSGKIMRRVLKAWELNLPAGD LSTMED*" /label="acsA CDS" gene complement(2558791..2560509) /gene="acsA" /locus_tag="BSU_29680" /old_locus_tag="BSU29680" /label="acsA gene" promotor_-35 2560523..2560530 /Source="Nicolas_upshift_promotors" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2560537..2560556) /Source="Nicolas_upshift_promotors" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2560545..2560564 /Source="Nicolas_upshift_promotors" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2560551 /Source="Nicolas_upshifts" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2560560) /Source="Nicolas_upshifts" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2560570..2560576) /Source="Nicolas_upshift_promotors" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2560593..2560600 /Source="Nicolas_upshift_promotors" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2560614..2560633 /Source="Nicolas_upshift_promotors" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2560617 /Source="Nicolas_upshifts" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="upshifts" CDS 2560670..2561302 /gene="acuA" /locus_tag="BSU_29690" /old_locus_tag="BSU29690" /EC_number="2.3.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328, 19136592, 24957627" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328, 19136592, 24957627; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein acetyltransferase (acetylates AcsA)" /protein_id="NP_390847.1" /db_xref="EnsemblGenomes-Gn:BSU29690" /db_xref="EnsemblGenomes-Tr:CAB14947" /db_xref="GOA:P39065" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR024699" /db_xref="SubtiList:BG10369" /db_xref="UniProtKB/Swiss-Prot:P39065" /translation="MEHHKTYHSANIKTATGSLLIEGPVSPEDLAGYEFHKDLTAFRP PREQHEALVDIAGLPEGRIIIARDGRTIVGYVTYLYPDPLERWSEGNMEDLIELGAIE VAPDYRGCAVGKTLLTVSMMDEQMENYIVMTTEYYWHWDLKGMKKDVWEYRKIMEKMM NAGGLVWFATDEPEISSHPANCLMARIGKNVSQESIEQFDRLRFYHRYMY*" /label="acuA CDS" gene 2560670..2561302 /gene="acuA" /locus_tag="BSU_29690" /old_locus_tag="BSU29690" /label="acuA gene" promotor_-35 2560875..2560883 /Source="Nicolas_upshift_promotors" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2560897..2560916 /Source="Nicolas_upshift_promotors" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2560903 /Source="Nicolas_upshifts" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="upshifts" CDS 2561329..2561973 /gene="acuB" /locus_tag="BSU_29700" /old_locus_tag="BSU29700" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328; Product type f : factor" /codon_start=1 /transl_table=11 /product="component of the acetyl-coenzyme A synthetase regulation pathway" /protein_id="NP_390848.1" /db_xref="EnsemblGenomes-Gn:BSU29700" /db_xref="EnsemblGenomes-Tr:CAB14948" /db_xref="GOA:P39066" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG10368" /db_xref="UniProtKB/Swiss-Prot:P39066" /translation="MIVEQIMKRDVITLTKTDTLETAICKLKEFHIRHLPVVDEERHV IGMITDRDMKQASPSIFEENKRSLFLTRSVDSIMKKDVVCAHPLDFVEEISAVFYEHG IGCLPVVHHQKLIGILTKTDLLRTFVKLTGADQPGSQIEIKVNDITKSLAEISSLCQD LQVKILSVLVYPHDDPGVKVLVFRVKTMNPLPFLQALQRNGHHVVWPSEQRDLL*" /label="acuB CDS" gene 2561329..2561973 /gene="acuB" /locus_tag="BSU_29700" /old_locus_tag="BSU29700" /label="acuB gene" CDS 2561970..2563133 /gene="acuC" /locus_tag="BSU_29710" /old_locus_tag="BSU29710" /EC_number="3.5.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein deacetylase (regulates AcsA activity)" /protein_id="NP_390849.1" /db_xref="EnsemblGenomes-Gn:BSU29710" /db_xref="EnsemblGenomes-Tr:CAB14949" /db_xref="GOA:P39067" /db_xref="InterPro:IPR000286" /db_xref="InterPro:IPR003085" /db_xref="InterPro:IPR023696" /db_xref="InterPro:IPR023801" /db_xref="InterPro:IPR037138" /db_xref="SubtiList:BG10367" /db_xref="UniProtKB/Swiss-Prot:P39067" /translation="MRDSVFIYSPSYQTYMFHQEHPFNQQRVLLTYDLLKTINAFDDG DIVTPRLASEEELSLVHTDDYIQAVKLAGAGKLPAEEGESYGLGTEDTPVFAGMHEAA SLLVGGTLTAADWVMSGQALHAANLGGGLHHGFRGRASGFCIYNDSAVAIQYIQKKYS ARVLYIDTDAHHGDGVQFTFYDNPDVCTLSIHETGRYLFPGTGQIQEKGSGKGYGYSF NIPLDAFTEDDSFLEAYRTAASEVAAYFEPDVIISQNGADAHYYDPLTHLSATINIYE EIPRLAHTLAHQYCGGKWIAVGGGGYDIWRVVPRAWARIWLEMKGIDPGHEIPPEWIV KWQKQCPVALPSSWSDPADLYPPIPRKPEITEKNAQTVSKALYAIRSEQQRTK*" /label="acuC CDS" gene 2561970..2563133 /gene="acuC" /locus_tag="BSU_29710" /old_locus_tag="BSU29710" /label="acuC gene" downshifts 2563124 /Source="Nicolas_upshifts" /id="D1530" /incds=0 /nref=98 /ntot=231 /MaxReadThrough="0.530530000000001" /MaxDrop="6.5095" /score="10.9528437" /energy="-9.1" /TU="NA" /idTUdmin="U2304" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2563144..2563872) /gene="motS" /locus_tag="BSU_29720" /old_locus_tag="BSU29720" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium channel stator-force generator peptidoglycan binding subunit of flagellar rotation" /protein_id="NP_390850.1" /db_xref="EnsemblGenomes-Gn:BSU29720" /db_xref="EnsemblGenomes-Tr:CAB14950" /db_xref="GOA:P39064" /db_xref="InterPro:IPR006665" /db_xref="InterPro:IPR025713" /db_xref="InterPro:IPR036737" /db_xref="SubtiList:BG10366" /db_xref="UniProtKB/Swiss-Prot:P39064" /translation="MKLRRERFERRNGSGKNSQSSSSWMVTFTDLITLILVFFILLFS MSQIDLQKFKAAVDSIQKEGNGLQPDQTSIEKKNTSPSDTKKQEDQQDQLLKKVNTYI KDNHLKAQMTAKRDERGVVLVLQEAVLFDTGEAKVLKNAETLLHQIAVLLQTIPNDIQ VEGHTDSRNISTYRYPSNWELSAARASGVIQYFTSKEKLPSKRFIAVGYADTKPVKDN KTNEHMKENRRVEIVIKKSKTTSS*" /label="motS CDS" gene complement(2563144..2563872) /gene="motS" /locus_tag="BSU_29720" /old_locus_tag="BSU29720" /label="motS gene" downshifts complement(2563180) /Source="Nicolas_upshifts" /id="D1531" /incds=0 /nref=37 /ntot=149 /MaxReadThrough="1.3853" /MaxDrop="3.98206" /score="4.77211813" /energy="-6.9" /TU="NA" /idTUdmin="U2307" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2563862..2564680) /gene="motP" /locus_tag="BSU_29730" /old_locus_tag="BSU29730" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium channel stator-force generator subunit offlagellar rotation" /protein_id="NP_390851.1" /db_xref="EnsemblGenomes-Gn:BSU29730" /db_xref="EnsemblGenomes-Tr:CAB14951" /db_xref="GOA:P39063" /db_xref="InterPro:IPR000540" /db_xref="InterPro:IPR002898" /db_xref="SubtiList:BG10365" /db_xref="UniProtKB/Swiss-Prot:P39063" /translation="MKRFDYLTPVGFVLGTIIIVIGIISGSGVSGFRSFLDLTSFFIV TGGLCAAVFISFPPSELKKAPSVLKQAFIRQEDNVKDLVKTFVSLSDHARKHGLLSLD DQAREIKDPFLKKGLLLAIDGWDEETIRLVMDSEIAAMEERHRKGRRVFEKAGEFAPA WGMIGTLVGLVLMLKNLNDPHMLGPNMAIALLTTLYGSLLANMVFNPIAAKLEEKTES EIFIKQVMVEGIIGVQSGKNPRNLESQLVVFSSREEWQKQPKQVKTKKGSVHEA*" /label="motP CDS" gene complement(2563862..2564680) /gene="motP" /locus_tag="BSU_29730" /old_locus_tag="BSU29730" /label="motP gene" CDS complement(2564743..2565747) /gene="ccpA" /locus_tag="BSU_29740" /old_locus_tag="BSU29740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11931564, 14665673, 16316990, 17085448, 17827291, 18757537, 19202299, 22001508, 22512862, 23123903, 25157083, 26712933, 28617843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11931564, 14665673, 16316990, 17085448, 17827291, 18757537, 19202299, 22001508, 22512862, 23123903, 25157083, 26712933, 28617843; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of catabolite repression (Lacl family)" /protein_id="NP_390852.1" /db_xref="EnsemblGenomes-Gn:BSU29740" /db_xref="EnsemblGenomes-Tr:CAB14952" /db_xref="GOA:P25144" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR006377" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="PDB:1ZVV" /db_xref="PDB:2FEP" /db_xref="PDB:3OQM" /db_xref="PDB:3OQN" /db_xref="PDB:3OQO" /db_xref="SubtiList:BG10376" /db_xref="UniProtKB/Swiss-Prot:P25144" /translation="MSNITIYDVAREANVSMATVSRVVNGNPNVKPTTRKKVLEAIER LGYRPNAVARGLASKKTTTVGVIIPDISSIFYSELARGIEDIATMYKYNIILSNSDQN MEKELHLLNTMLGKQVDGIVFMGGNITDEHVAEFKRSPVPIVLAASVEEQEETPSVAI DYEQAIYDAVKLLVDKGHTDIAFVSGPMAEPINRSKKLQGYKRALEEANLPFNEQFVA EGDYTYDSGLEALQHLMSLDKKPTAILSATDEMALGIIHAAQDQGLSIPEDLDIIGFD NTRLSLMVRPQLSTVVQPTYDIGAVAMRLLTKLMNKEPVEEHIVELPHRIELRKSTKS *" /label="ccpA CDS" gene complement(2564743..2565747) /gene="ccpA" /locus_tag="BSU_29740" /old_locus_tag="BSU29740" /label="ccpA gene" downshifts complement(2564760) /Source="Nicolas_upshifts" /id="D1532" /incds=0 /nref=62 /ntot=239 /MaxReadThrough="4.60553" /MaxDrop="4.6531" /score="5.3377823" /energy="-13.2" /TU="U2307,U2308,U2309" /idTUdmin="U2306" /TUdmin=3 /isTUend="TRUE" /label="downshifts" misc_feature complement(2565782..2565801) /Source="Nicolas_upshift_promotors" /id="U2306" /multdbtbs="-" /comp="M5" /sig="SigA" /pcomp="0.366633366633367" /psig="0.577422577422577" /xcortree=1443 /SigmaFactorBS="cgcttacaaatcataaacgacataaattcggacattatgaca tttctctacataaaGTGTTTATGCTATAGATAAGgataagtgtatccagtaaaaggag t" /listShort="ccpA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2565797) /Source="Nicolas_upshifts" /id="U2306" /multdbtbs="-" /comp="M5" /sig="SigA" /pcomp="0.366633366633367" /psig="0.577422577422577" /xcortree=1443 /SigmaFactorBS="cgcttacaaatcataaacgacataaattcggacattatgaca tttctctacataaaGTGTTTATGCTATAGATAAGgataagtgtatccagtaaaaggag t" /listShort="ccpA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2565799..2565907) /Source="Nicolas_S_feature" /locus_tag="new_3045221_3045329_c" /HighExp="Oxctl, H2O2, Paraq, MG-0.1, MG-0.2, G150, GM 15, Diami, LBGexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigB" /TUshortPSig="0.988, 1, 0.974, 1" /TUlongSig="SigH" /TUlongPSig=1 /label="S1139" promotor_-10 complement(2565907..2565926) /Source="Nicolas_upshift_promotors" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2565907) /Source="Nicolas_upshifts" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2565909..2565974) /Source="Nicolas_S_feature" /locus_tag="new_3045331_3045396_c" /HighExp="BMM, GM 120, Diami, GM 90, M/G, GM 25, M9-exp, HiTm, G180, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="1, 0.974, 1" /TUlongSig="SigH" /TUlongPSig=1 /label="S1140" promotor_-35 complement(2565940..2565946) /Source="Nicolas_upshift_promotors" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2566020) /Source="Nicolas_upshifts" /id="D1533" /incds=0 /nref=66 /ntot=188 /MaxReadThrough="6.10221" /MaxDrop="6.29667" /score="46.0872381" /energy="-11.3" /TU="U2308,U2309,U2310" /idTUdmin="U2311" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2566023..2567099) /gene="aroX" /locus_tag="BSU_29750" /old_locus_tag="BSU29750" /EC_number="2.5.1.54" /EC_number="5.4.99.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4200844, 7496534, 11444986, 16339761, 28743924" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4200844, 7496534, 11444986, 16339761, 28743924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional chorismate mutase type II-isozyme 3(regulatory domain); 3-deoxy-D-arabino-heptulosonate7-phosphate synthase" /protein_id="NP_390853.1" /db_xref="EnsemblGenomes-Gn:BSU29750" /db_xref="EnsemblGenomes-Tr:CAB14953" /db_xref="GOA:P39912" /db_xref="InterPro:IPR002701" /db_xref="InterPro:IPR006218" /db_xref="InterPro:IPR006268" /db_xref="InterPro:IPR010954" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036979" /db_xref="PDB:5GMU" /db_xref="PDB:5GO2" /db_xref="SubtiList:BG10375" /db_xref="UniProtKB/Swiss-Prot:P39912" /translation="MSNTELELLRQKADELNLQILKLINERGNVVKEIGKAKEAQGVN RFDPVRERTMLNNIIENNDGPFENSTIQHIFKEIFKAGLELQEEDHSKALLVSRKKKP EDTIVDIKGEKIGDGQQRFIVGPCAVESYEQVAEVAAAAKKQGIKILRGGAFKPRTSP YDFQGLGVEGLQILKRVADEFDLAVISEIVTPAHIEEALDYIDVIQIGARNMQNFELL KAAGAVKKPVLLKRGLAATISEFINAAEYIMSQGNDQIILCERGIRTYETATRNTLDI SAVPILKQETHLPVFVDVTHSTGRRDLLLPTAKAALAIGADGVMAEVHPDPSVALSDS AQQMAIPEFEKWLNELKPMVKVNA*" /label="aroX CDS" gene complement(2566023..2567099) /gene="aroX" /locus_tag="BSU_29750" /old_locus_tag="BSU29750" /label="aroX gene" promotor_-10 complement(2567140..2567159) /Source="Nicolas_upshift_promotors" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="promotor_-10" upshifts complement(2567160) /Source="Nicolas_upshifts" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="upshifts" S_feature complement(2567162..2567262) /Source="Nicolas_S_feature" /locus_tag="new_3046584_3046684_c" /HighExp="Lbtran, BMM, dia5, GM 25, GM 90, M9-exp, MG 150, Diami, MG-0.2, SMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigH" /TUshortPSig="0.974, 1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1141" promotor_-35 complement(2567174..2567181) /Source="Nicolas_upshift_promotors" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="promotor_-35" downshifts 2567196 /Source="Nicolas_upshifts" /id="D1534" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="2.07872" /MaxDrop="3.23284" /score="1.10447256" /energy="-7.6" /TU="NA" /idTUdmin="U2304" /TUdmin=4071 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2567250..2567269) /Source="Nicolas_upshift_promotors" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2567262) /Source="Nicolas_upshifts" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2567283..2567289) /Source="Nicolas_upshift_promotors" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2567335..2567661) /gene="brxJ" /locus_tag="BSU_29760" /old_locus_tag="BSU29760" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8733232, 22938038, 25852656" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8733232, 22938038, 25852656; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacilliredoxin involved in debacillithiolation" /protein_id="NP_390854.1" /db_xref="EnsemblGenomes-Gn:BSU29760" /db_xref="EnsemblGenomes-Tr:CAB14954" /db_xref="InterPro:IPR022551" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10373" /db_xref="UniProtKB/Swiss-Prot:P39914" /translation="MAKQLIQSEEEFKRIAEQEGVFVFLKHSTTCPISQAAFHEFDAF ANQHEDVPAYYLQVQEARPLSNFIAETYGVKHESPQIFIIQNGEVKWHTSHSQITEAA IEQHLS*" /label="brxJ CDS" gene complement(2567335..2567661) /gene="brxJ" /locus_tag="BSU_29760" /old_locus_tag="BSU29760" /label="brxJ gene" downshifts complement(2567344) /Source="Nicolas_upshifts" /id="D1535" /incds=0 /nref=144 /ntot=286 /MaxReadThrough="7.09736" /MaxDrop="5.96753" /score="13.8032115" /energy="-7.6" /TU="U2310,U2311" /idTUdmin="U2313" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(2567685..2568140) /gene="ytxH" /locus_tag="BSU_29770" /old_locus_tag="BSU29770" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 8733232, 16291680" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390855.2" /db_xref="EnsemblGenomes-Gn:BSU29770" /db_xref="EnsemblGenomes-Tr:CAB14955" /db_xref="InterPro:IPR024623" /db_xref="SubtiList:BG10975" /db_xref="UniProtKB/Swiss-Prot:P40780" /translation="MSKDGINSKDFLIGTLIGGIIGATTALFLAPKSGKELRDDLGSQ AVALRDKTDKMTADAKEKGTQYVSIAKDKTSNITQLVADQSGQIMNKVKDLRDRSKSD KTDSSTAMQDMREEAMQAADETKDQVLQTKEDVKDELKDAQKQAEQLNR*" /label="ytxH CDS" gene complement(2567685..2568140) /gene="ytxH" /locus_tag="BSU_29770" /old_locus_tag="BSU29770" /label="ytxH gene" CDS complement(2568171..2568593) /gene="ytxG" /locus_tag="BSU_29780" /old_locus_tag="BSU29780" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8733232, 22720735, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8733232, 22720735, 26735940; Product type f: factor" /codon_start=1 /transl_table=11 /product="general stress protein" /protein_id="NP_390856.2" /db_xref="EnsemblGenomes-Gn:BSU29780" /db_xref="EnsemblGenomes-Tr:CAB14956" /db_xref="GOA:P40779" /db_xref="InterPro:IPR009293" /db_xref="SubtiList:BG10974" /db_xref="UniProtKB/Swiss-Prot:P40779" /translation="MIIILYLSVALIAVAFLVLVIYLSKTLKSLQLTLKNVASTLEGL EGQMKGITTETAELLHKTNRLAEDIQEKSEKLNTVVHAVQGVGASVQQFNTSMKQAAG SVSASVRENQDKINQVVTWSQAAMEIWEKWKQKKKSAL*" /label="ytxG CDS" gene complement(2568171..2568593) /gene="ytxG" /locus_tag="BSU_29780" /old_locus_tag="BSU29780" /label="ytxG gene" promotor_-10 complement(2568614..2568632) /Source="Nicolas_upshift_promotors" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2568627) /Source="Nicolas_upshifts" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2568646..2568652) /Source="Nicolas_upshift_promotors" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2568666..2568684) /Source="Nicolas_upshift_promotors" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="promotor_-10" upshifts complement(2568675) /Source="Nicolas_upshifts" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="upshifts" promotor_-35 complement(2568695..2568703) /Source="Nicolas_upshift_promotors" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="promotor_-35" CDS complement(2568755..2570053) /gene="murC" /locus_tag="BSU_29790" /old_locus_tag="BSU29790" /EC_number="6.3.2.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10565540, 12682299, 12781748; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetyl muramate-alanine ligase" /protein_id="NP_390857.1" /db_xref="EnsemblGenomes-Gn:BSU29790" /db_xref="EnsemblGenomes-Tr:CAB14957" /db_xref="GOA:P40778" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005758" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10973" /db_xref="UniProtKB/Swiss-Prot:P40778" /translation="MTVYHFVGIKGTGMSPLAQILHDNGYTVQGSDIEKFIFTQTALE KRNITILPFSAENIKPGMTVIAGNAFPDTHPEIEKAMSEGIPVIRYHKFLGDYMKKFT SVAVTGAHGKTSTTGLLAHVIQNAKPTSFLIGDGTGQGNENSEYFVFEACEYRRHFLS YQPDYAIMTNIDFDHPDYFSSIDDVFDAFQEMALQVNKGIIACGDDEHLPKIHANVPV VYYGTGEENDFQARNIVKSTEGTTFDVFVRNTFYDTFYIPAYGHHNVLNSLAVIALCH YEEIDSSIIKHALKSFGGVKRRFNEKQLGDQVLIDDYAHHPTEIKVTIEAARQKYPDR EIVAVFQPHTFTRTQQFLDEFAESLSGADCVYLCDIFGSARENAGKLTIGDLQGKIHN AKLIEEDDTSVLKAHDKAVLIFMGAGDIQKYMRAYENVMA*" /label="murC CDS" gene complement(2568755..2570053) /gene="murC" /locus_tag="BSU_29790" /old_locus_tag="BSU29790" /label="murC gene" downshifts complement(2568764) /Source="Nicolas_upshifts" /id="D1536" /incds=0 /nref=29 /ntot=180 /MaxReadThrough="5.23049" /MaxDrop="5.42617" /score="15.3729968" /energy="-7.5" /TU="U2313,U2314" /idTUdmin="U2312" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2570078..2570097) /Source="Nicolas_upshift_promotors" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2570079) /Source="Nicolas_upshifts" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2570081..2570277) /Source="Nicolas_S_feature" /locus_tag="new_3049503_3049699_c" /HighExp="Cold, G150, G135, dia15, G180, H2O2, C30, Oxctl, Paraq, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.938" /label="S1142" promotor_-35 complement(2570110..2570119) /Source="Nicolas_upshift_promotors" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2570260..2570279) /Source="Nicolas_upshift_promotors" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2570277) /Source="Nicolas_upshifts" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2570291..2570297) /Source="Nicolas_upshift_promotors" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2570303..2573161) /gene="sftA" /locus_tag="BSU_29805" /old_locus_tag="BSU29805" /function="8.1: DNA replication, recombination, and repair" /experiment="publication(s) with functional evidences, PMID:3129532, 11134515, 11208805, 19788545, 28110333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3129532, 11134515, 11208805, 19788545, 28110333; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="DNA translocase" /protein_id="NP_390859.2" /db_xref="EnsemblGenomes-Gn:BSU29805" /db_xref="EnsemblGenomes-Tr:CAB14959" /db_xref="GOA:C0SP86" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR018541" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13906" /db_xref="UniProtKB/Swiss-Prot:C0SP86" /translation="MSWLHKFFDLFLGESEEDAERETKPAQIPQQQEVHHPEGQLKRL EDPKIYYEYPKGKFRFPVVPDGYKNHDLRRRRTPSDEPKSAPRPSAAPYRERPRNEEE QHTYQAAEPAKKPFKPTNIPSPVYGFNQKPSVKKDVPKKPSETLNEPDKSVKEKVTLL SEEIERERGYPASDTQAHSKIESPFFPDTQFEKQPSGVLNRKDTEHDEALAKRPAEPS GNKVPFESGVQQPEKEEPFFPAEQAEEQTPPEMLTDTAAEGLSDSEVGREEPATAEEE QREQQPEKFEEPVFSAELDEEQTAPESQTEAVSEDEKAKEPSDSPVYNHHENAAEGAE SPFVQEEQMDIRQEEPLFTDHEYSSEALAQAETVAKESEEPSESIINNHYDTLGEAQE TKIDVQPDSHTELEKTEHMEQGSKSSTATLENRQEIRADKPREASEEPKKRPGVQEKR TEQSASSQKGPSVPFNVMMLKRDTHKQQKAEERRGSYVFPNVALLDVPPAQVQDDTAW IEEQRQLLDLTLKNFNVRANVVHVTQGPSVTRFEVHPEPGVKVNKITNLSDDIKLSLS AKDIRIEAPIPGKNTIGIEVPNRTSKVVDLRQMIRSSAFRTSKSPLTAALGLDISGNP VVIDLKKMPHGLIAGATGSGKSVCINTILVSLLYKADPSEVKVLLIDPKMVELAPYNK IPHLVSPVITDAKAATAALKWVVEEMERRYELFAHSGVRDIDRFNQLTAEHQMGEKLP YLVVIIDELADLMMVAPNDVEESIARIAQKARACGIHLLVATQRPSVDVITGLIKANI PTRIAFSVSSQVDSRTIIDIAGAEKLLGKGDMLFLENGSGKPVRLQGNFVSDREIDRV VSHVRSQMPPTYLFEQEELVRQGSALKEEDELFYEACEFVVEQNSASTSSLQRRFRIG YNRAARLIDMMEAEGMISEAKGSKPREVLITASDLINE*" /label="sftA CDS" gene complement(2570303..2573161) /gene="sftA" /locus_tag="BSU_29805" /old_locus_tag="BSU29805" /label="sftA gene" promotor_-10 complement(2573195..2573214) /Source="Nicolas_upshift_promotors" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="promotor_-10" upshifts complement(2573205) /Source="Nicolas_upshifts" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="upshifts" promotor_-35 complement(2573230..2573234) /Source="Nicolas_upshift_promotors" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="promotor_-35" downshifts complement(2573304) /Source="Nicolas_upshifts" /id="D1537" /incds=0 /nref=186 /ntot=249 /MaxReadThrough="4.47299" /MaxDrop="6.35097" /score="9.62039509" /energy="-14.5" /TU="U2315" /idTUdmin="U2315" /TUdmin="-1553" /isTUend="FALSE" /label="downshifts" CDS complement(2573321..2573926) /gene="ytpR" /locus_tag="BSU_29820" /old_locus_tag="BSU29820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21949854, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA binding enzyme" /protein_id="NP_390860.1" /db_xref="EnsemblGenomes-Gn:BSU29820" /db_xref="EnsemblGenomes-Tr:CAB14960" /db_xref="GOA:O34943" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027855" /db_xref="InterPro:IPR033714" /db_xref="InterPro:IPR037154" /db_xref="SubtiList:BG13905" /db_xref="UniProtKB/Swiss-Prot:O34943" /translation="MNAFYNKEGVGDTLLISLQDVTREQLGYEKHGDVVKIFNNETKE TTGFNIFNASSYLTIDENGPVALSETFVQDVNEILNRNGVEETLVVDLSPKFVVGYVE SKEKHPNADKLSVCKVNVGEETLQIVCGAPNVDQGQKVVVAKVGAVMPSGLVIKDAEL RGVPSSGMICSAKELDLPDAPAEKGILVLEGDYEAGDAFQF*" /label="ytpR CDS" gene complement(2573321..2573926) /gene="ytpR" /locus_tag="BSU_29820" /old_locus_tag="BSU29820" /label="ytpR gene" CDS complement(2573942..2574751) /gene="ytpQ" /locus_tag="BSU_29830" /old_locus_tag="BSU29830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12719520, 21949854" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (iron homeostasis)" /protein_id="NP_390861.1" /db_xref="EnsemblGenomes-Gn:BSU29830" /db_xref="EnsemblGenomes-Tr:CAB14961" /db_xref="InterPro:IPR010838" /db_xref="SubtiList:BG13904" /db_xref="UniProtKB/Swiss-Prot:O34496" /translation="MKMTSRKLSDILKQRLQHENRSFLFDREKDTLRVEDQTTKKGIT LDLPPIIAKWELKKDEAIDEIVYYVSEAMTAMEGKAQEMTGKETRIYPVIRSTSFPDK SSEDIPLIYDDHTAETRIYYALDLGKTYRLIDQRMLEKENWTKERIRETAAFNLRSLP TVVKEDTVAGNYFYFFRANDGYDASRILNEAILNEYKQHAEGELAISVPHQDVLILAD IRNESGYDILGQMSMSFFAGGTVPITALSFLYNEGKLEPVFILAKSRPKKD*" /label="ytpQ CDS" gene complement(2573942..2574751) /gene="ytpQ" /locus_tag="BSU_29830" /old_locus_tag="BSU29830" /label="ytpQ gene" CDS complement(2574766..2575089) /gene="ytpP" /locus_tag="BSU_29840" /old_locus_tag="BSU29840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12719520, 15937154, 21949854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase with thioredoxin domain" /protein_id="NP_390862.1" /db_xref="EnsemblGenomes-Gn:BSU29840" /db_xref="EnsemblGenomes-Tr:CAB14962" /db_xref="GOA:O34357" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13903" /db_xref="UniProtKB/Swiss-Prot:O34357" /translation="MKKIESTQELEKAVKDDWSVFMFSADWCPDCRFVEPFLPELEAN FPEFTYYYVDRDKFIDTCAEWEIYGIPSFVVFNEGKEVNRFVSKDRKTKEEIEQFLTD SLAKA*" /label="ytpP CDS" gene complement(2574766..2575089) /gene="ytpP" /locus_tag="BSU_29840" /old_locus_tag="BSU29840" /label="ytpP gene" S_feature complement(2575090..2575228) /Source="Nicolas_S_feature" /locus_tag="new_3054512_3054650_c" /HighExp="G180, G150, Paraq, Oxctl, H2O2, Diami, C90, dia15, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.32150299999999998" /TUshortSig="SigA" /TUshortPSig="0.938" /TUlongSig="NA" /TUlongPSig="NA" /label="S1143" CDS complement(2575128..2575244) /locus_tag="BSU_29845" /old_locus_tag="BSU29845" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513998.1" /translation="MQIKYDNDNGKANLTYSFVAYKWFCLKQFGMIQMDEYR*" /label="hypothetical protein CDS" gene complement(2575128..2575244) /locus_tag="BSU_29845" /old_locus_tag="BSU29845" /label="gene" promotor_-10 complement(2575215..2575234) /Source="Nicolas_upshift_promotors" /id="U2315" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.515484515484515" /psig="0.938061938061938" /xcortree=2564 /SigmaFactorBS="atttcaccctcatgtacacgatgttaaacgaaacgagcTtga taatgcaaataaAATATGATAATGATAATGGGaaagccaatcttacatattcattcgt t" /listShort="S1143, ytpP, ytpQ, ytpR, ytpS" /listLong="S1142, murC, ytxG, ytxH, ytxJ" /label="promotor_-10" upshifts complement(2575228) /Source="Nicolas_upshifts" /id="U2315" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.515484515484515" /psig="0.938061938061938" /xcortree=2564 /SigmaFactorBS="atttcaccctcatgtacacgatgttaaacgaaacgagcTtga taatgcaaataaAATATGATAATGATAATGGGaaagccaatcttacatattcattcgt t" /listShort="S1143, ytpP, ytpQ, ytpR, ytpS" /listLong="S1142, murC, ytxG, ytxH, ytxJ" /label="upshifts" promotor_-35 2575236..2575243 /Source="Nicolas_upshift_promotors" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2575258..2575277 /Source="Nicolas_upshift_promotors" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2575263 /Source="Nicolas_upshifts" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="upshifts" CDS 2575324..2575770 /gene="ytoQ" /locus_tag="BSU_29850" /old_locus_tag="BSU29850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme with sugar binding fold" /protein_id="NP_390863.1" /db_xref="EnsemblGenomes-Gn:BSU29850" /db_xref="EnsemblGenomes-Tr:CAB14963" /db_xref="InterPro:IPR019884" /db_xref="SubtiList:BG13899" /db_xref="UniProtKB/Swiss-Prot:O34305" /translation="MEFIVYLAGEIHSNWREEIKEKTKSLKLPITFVGPMENHDRSDN IGEEIMGVQPNAVLKDDKASDINNFRTAVLMNKADFVIALFGEKYKQWNTAMDASYAI AKGKPLIIIRPESLHHPLKELSNKANITVETVNQAIKALSYLFETE*" /label="ytoQ CDS" gene 2575324..2575770 /gene="ytoQ" /locus_tag="BSU_29850" /old_locus_tag="BSU29850" /label="ytoQ gene" S_feature 2575771..2576499 /Source="Nicolas_S_feature" /locus_tag="new_3055193_3055921" /HighExp="H2O2, dia15, C30, C90, Diami, S1, M0t45, Salt, Paraq, Lbexp" /AntisenseName="ytoP" /AntisenseCor="0.35418735783791" /AntisenseRegPval="-8.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.981" /TUlongSig="NA" /TUlongPSig="NA" /label="S1144" CDS complement(2575825..2576898) /gene="ytoP" /locus_tag="BSU_29860" /old_locus_tag="BSU29860" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8535515; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative modified amino acid aminopeptidase" /protein_id="NP_390864.1" /db_xref="EnsemblGenomes-Gn:BSU29860" /db_xref="EnsemblGenomes-Tr:CAB14964" /db_xref="GOA:O34924" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="SubtiList:BG13898" /db_xref="UniProtKB/Swiss-Prot:O34924" /translation="MNQETKALFQTLTQLPGAPGNEHQVRAFMKQELAKYADDIVQDR LGSVFGVRRGAEDAPRIMVAGHMDEVGFMVTSITDNGLLRFQTLGGWWSQVLLAQRVE IQTDNGPVPGVISSIPPHLLTDAQRNRPMDIKNMMIDIGADDKEDAIKIGIRPGQQIV PVCPFTTMANEKKILSKAWDNRYGCGLSIELLKELHGKELPNTLYAGATVQEEVGLRG AQTASHMIKPDLFFALDASPANDMSGDKNEFGQLGKGFLLRILDRTTVMHRGMREFVL DMAETHDIPYQYFVSGGGTDAGKVHISNSGVPSAVIGICSRYIHTNATIIHIDDYAAA KEMLIKLVTACDKQTVDAIKENM*" /label="ytoP CDS" gene complement(2575825..2576898) /gene="ytoP" /locus_tag="BSU_29860" /old_locus_tag="BSU29860" /label="ytoP gene" downshifts complement(2575844) /Source="Nicolas_upshifts" /id="D1538" /incds=0 /nref=140 /ntot=248 /MaxReadThrough="1.89952" /MaxDrop="4.55096" /score="14.9571314" /energy="-14.4" /TU="NA" /idTUdmin="U2317" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2576920..2576939) /Source="Nicolas_upshift_promotors" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2576924) /Source="Nicolas_upshifts" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2576953..2576960) /Source="Nicolas_upshift_promotors" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2576995..2576998 /Source="Nicolas_upshift_promotors" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2577013..2577032 /Source="Nicolas_upshift_promotors" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2577018 /Source="Nicolas_upshifts" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="upshifts" CDS 2577057..2577374 /gene="ytzB" /locus_tag="BSU_29870" /old_locus_tag="BSU29870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390865.1" /db_xref="EnsemblGenomes-Gn:BSU29870" /db_xref="EnsemblGenomes-Tr:CAB14965" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13936" /db_xref="UniProtKB/Swiss-Prot:O32065" /translation="MKLRHLLLGAGLGICTAVVVRQYVMKPYISSEKALRIVKSAFKQ RGPIDGSWIYTQPEPYNINGETVQVYKTGITRSAFGELEQYEVMVDAKTGEIVDVIDT IAS*" /label="ytzB CDS" gene 2577057..2577374 /gene="ytzB" /locus_tag="BSU_29870" /old_locus_tag="BSU29870" /label="ytzB gene" downshifts 2577374 /Source="Nicolas_upshifts" /id="D1539" /incds=0 /nref=250 /ntot=259 /MaxReadThrough="1.29231" /MaxDrop="7.83082" /score="44.9062865" /energy="-17" /TU="NA" /idTUdmin="U2318" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2577427..2579127) /gene="maeC" /locus_tag="BSU_29880" /old_locus_tag="BSU29880" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 20933603, 22740702, 23136871, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 20933603, 22740702, 23136871, 24325460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD-dependent malic enzyme (conversion of malateinto pyruvate)" /protein_id="NP_390866.1" /db_xref="EnsemblGenomes-Gn:BSU29880" /db_xref="EnsemblGenomes-Tr:CAB14966" /db_xref="GOA:O34389" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG12614" /db_xref="UniProtKB/Swiss-Prot:O34389" /translation="MKQFRVTNEGDIQTTLRGLEVLSVPFLNKGVAFTEEERKELGLK GFLPPKVLTIDDQAKRAYEQYSAQPDDLSKNVYLTALHDRNETLFYRLLNDHLGEMLP IVYTPTVGTAIQRYSHEYRKPRGLYLSIDDPDGMKEAFKQYKDQSDTIDLIVATDAEG ILGIGDWGVGGIAISIGKLAVYTAAAGIDPSRVLAVVLDAGTNQESLLNDPLYVGNQH SRVRGERYDQFIDDYVALARETFPNALLHWEDFGAKNARSILKRYKDKVCTFNDDIQG TGAVSLAAVLSCAKASKVPLRDHRVVIFGAGTAGIGIAEQLREALVREGLSEEESYKR FWCIDRNGLLTDDMDQLLDFQKPYARSADEVKDYQRNGDGGGIDLLEVVRQAKPTILI GTSTVSGAFTEEIVKEMASHVKRPAILPMSNPTTLSEAKPEDLIEWTEGRALITTGSP FPPVEYNGVTYHIGQANNALVFPGLGLGTIVTKSKLITDGMFEACARAIAGMVNVGVP GAPMLPKVEDLRTVSATVAVEVAKTAMKEGVATEEPEDIIQAVQDAMWYPVYKPIRAI *" /label="maeC CDS" gene complement(2577427..2579127) /gene="maeC" /locus_tag="BSU_29880" /old_locus_tag="BSU29880" /label="maeC gene" downshifts complement(2577446) /Source="Nicolas_upshifts" /id="D1540" /incds=0 /nref=77 /ntot=255 /MaxReadThrough="2.4872" /MaxDrop="4.99085" /score="17.675308" /energy="-15.3" /TU="NA" /idTUdmin="U2319" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2579159..2579177) /Source="Nicolas_upshift_promotors" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2579166) /Source="Nicolas_upshifts" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2579192..2579198) /Source="Nicolas_upshift_promotors" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2579209..2579979) /gene="ytnP" /locus_tag="BSU_29890" /old_locus_tag="BSU29890" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22101040, 24268182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative quorum-quenching lactonase" /protein_id="NP_390867.1" /db_xref="EnsemblGenomes-Gn:BSU29890" /db_xref="EnsemblGenomes-Tr:CAB14967" /db_xref="GOA:O34760" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13895" /db_xref="UniProtKB/Swiss-Prot:O34760" /translation="MFGVVPKPLWSKKYPVNEKNQIELRTDPILIQKDGLNIIIDAGI GYGKLTDKQKRNYGVTQESNVKPSLAALGLTVADIDVIAMTHLHFDHACGLTEYEGER LVSVFPNAVIYTSAVEWDEMRHPNIRSKNTYWKENWEAVAGQVKTFEDTLTITEGITM HHTGGHSDGHSVLICEDAGETAVHMADLMPTHAHRNPLWVLAYDDYPMTSIPQKQKWQ AFAAEKDAWFIFYHDAEYRALQWEEDGSIKKSVKRMKR*" /label="ytnP CDS" gene complement(2579209..2579979) /gene="ytnP" /locus_tag="BSU_29890" /old_locus_tag="BSU29890" /label="ytnP gene" S_feature complement(2579980..2580068) /Source="Nicolas_S_feature" /locus_tag="new_3059402_3059490_c" /HighExp="HiOs, M40t90, T0.30H, T1.30H, T3.0H, T1.0H, Sw, T2.30H, T3.30H, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1145" promotor_-10 complement(2580066..2580085) /Source="Nicolas_upshift_promotors" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2580068) /Source="Nicolas_upshifts" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2580101..2580105) /Source="Nicolas_upshift_promotors" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2580125..2580766) /gene="trmB" /locus_tag="BSU_29900" /old_locus_tag="BSU29900" /EC_number="2.1.1.33" /function="16.6: Maintain" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15789416, 16600901, 17150909, 19934251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15789416, 16600901, 17150909, 19934251; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (guanine-N(7)-)-methyltransferase" /protein_id="NP_390868.1" /db_xref="EnsemblGenomes-Gn:BSU29900" /db_xref="EnsemblGenomes-Tr:CAB14968" /db_xref="GOA:O34522" /db_xref="InterPro:IPR003358" /db_xref="InterPro:IPR029063" /db_xref="PDB:2FCA" /db_xref="SubtiList:BG13890" /db_xref="UniProtKB/Swiss-Prot:O34522" /translation="MRMRHKPWADDFLAENADIAISNPADYKGKWNTVFGNDNPIHIE VGTGKGQFISGMAKQNPDINYIGIELFKSVIVTAVQKVKDSEAQNVKLLNIDADTLTD VFEPGEVKRVYLNFSDPWPKKRHEKRRLTYSHFLKKYEEVMGKGGSIHFKTDNRGLFE YSLKSFSEYGLLLTYVSLDLHNSNLEGNIMTEYEEKFSALGQPIYRAEVEWRT*" /label="trmB CDS" gene complement(2580125..2580766) /gene="trmB" /locus_tag="BSU_29900" /old_locus_tag="BSU29900" /label="trmB gene" downshifts complement(2580135) /Source="Nicolas_upshifts" /id="D1541" /incds=0 /nref=46 /ntot=131 /MaxReadThrough="3.31031" /MaxDrop="5.64644" /score="29.2137061" /energy="-10.1" /TU="NA" /idTUdmin="U2321" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts complement(2580200) /Source="Nicolas_upshifts" /id="D1542" /incds=1 /nref=39 /ntot=202 /MaxReadThrough="6.31908" /MaxDrop="3.64275" /score="29.2137061" /energy="-10.1" /TU="U2321,U2323" /idTUdmin="U2323" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2580792..2580811) /Source="Nicolas_upshift_promotors" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2580801) /Source="Nicolas_upshifts" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2580803..2581251) /Source="Nicolas_S_feature" /locus_tag="new_3060225_3060673_c" /HighExp="C30, Cold, G135, G180, B60, Paraq, G150, Oxctl, H2O2, LBGstat" /AntisenseName="ytzH" /AntisenseCor="-0.51149457663808795" /AntisenseRegPval="-18.600000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.992" /label="S1146" promotor_-35 complement(2580827..2580831) /Source="Nicolas_upshift_promotors" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2580910..2580916 /Source="Nicolas_upshift_promotors" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2580931..2580942 /Source="Nicolas_upshift_promotors" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2580938 /Source="Nicolas_upshifts" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="upshifts" CDS 2580973..2581251 /gene="ytzH" /locus_tag="BSU_29910" /old_locus_tag="BSU29910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390869.1" /db_xref="EnsemblGenomes-Gn:BSU29910" /db_xref="EnsemblGenomes-Tr:CAB14969" /db_xref="InterPro:IPR025547" /db_xref="SubtiList:BG13942" /db_xref="UniProtKB/Swiss-Prot:O32066" /translation="MGLHYEHQVHLLKDILTDHQLDCCGTVAEYEQLERVIKSLMANT ELDSNFKNVLEDVYRYSQSGISSKSIDSHIQEHQNSLSQWVEQMDSYS*" /label="ytzH CDS" gene 2580973..2581251 /gene="ytzH" /locus_tag="BSU_29910" /old_locus_tag="BSU29910" /label="ytzH gene" S_feature 2581252..2581422 /Source="Nicolas_S_feature" /locus_tag="new_3060674_3060844" /HighExp="S5, S7, S8, S6, S4, BT, C30, nit, ferm, G/S" /AntisenseName="ytmP" /AntisenseCor="-0.32108027439793901" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1147" CDS complement(2581252..2581866) /gene="ytmP" /locus_tag="BSU_29920" /old_locus_tag="BSU29920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9026440, 11545674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative kinase/phosphotransferase" /protein_id="NP_390870.2" /db_xref="EnsemblGenomes-Gn:BSU29920" /db_xref="EnsemblGenomes-Tr:CAB14970" /db_xref="GOA:C0SPC1" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG13889" /db_xref="UniProtKB/Swiss-Prot:C0SPC1" /translation="MENGDVITAQHWMTGRELKPKDMSGRPVAELLRKIHTSKALLDM LKRLGKEPLNPGALLSQLKQAVFAVQQSSPLIQEGIKYLEEHLHEVHFGEKVVCHCDV NHNNWLLSEDNQLYLIDWDGAMIADPAMDLGPLLYHYVEKPAWESWLSMYGIELTESL RLRMAWYVLSETITFIAWHKAKGNDKEFHDAMEELHILMKRIVD*" /label="ytmP CDS" gene complement(2581252..2581866) /gene="ytmP" /locus_tag="BSU_29920" /old_locus_tag="BSU29920" /label="ytmP gene" downshifts 2581400 /Source="Nicolas_upshifts" /id="D1543" /incds=1 /nref=4 /ntot=35 /MaxReadThrough="2.54837" /MaxDrop="3.82368" /score="-4.89809956" /energy="-11.3" /TU="NA" /idTUdmin="U2322" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2581867..2582202) /Source="Nicolas_S_feature" /locus_tag="new_3061289_3061624_c" /HighExp="T1.30H, M9-stat, T2.30H, T3.0H, UNK1, B60, T2.0H, T3.30H, T1.0H, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.992" /label="S1148" promotor_-10 complement(2582194..2582213) /Source="Nicolas_upshift_promotors" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2582202) /Source="Nicolas_upshifts" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2582228..2582235) /Source="Nicolas_upshift_promotors" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2582229..2584385) /gene="amyX" /locus_tag="BSU_29930" /old_locus_tag="BSU29930" /EC_number="3.2.1.41" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9453151, 16582490, 19465663, 23973973" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9453151, 16582490, 19465663, 23973973; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pullulanase" /protein_id="NP_390871.2" /db_xref="EnsemblGenomes-Gn:BSU29930" /db_xref="EnsemblGenomes-Tr:CAB14971" /db_xref="GOA:C0SPA0" /db_xref="InterPro:IPR004193" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR011840" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR017853" /db_xref="PDB:2E8Y" /db_xref="PDB:2E8Z" /db_xref="PDB:2E9B" /db_xref="SubtiList:BG12566" /db_xref="UniProtKB/Swiss-Prot:C0SPA0" /translation="MVSIRRSFEAYVDDMNIITVLIPAEQKEIMTPPFRLETEITDFP LAVREEYSLEAKYKYVCVSDHPVTFGKIHCVRASSGHKTDLQIGAVIRTAAFDDEFYY DGELGAVYTADHTVFKVWAPAATSAAVKLSHPNKSGRTFQMTRLEKGVYAVTVTGDLH GYEYLFCICNNSEWMETVDQYAKAVTVNGEKGVVLRPDQMKWTAPLKPFSHPVDAVIY ETHLRDFSIHENSGMINKGKYLALTETDTQTANGSSSGLAYVKELGVTHVELLPVNDF AGVDEEKPLDAYNWGYNPLHFFAPEGSYASNPHDPQTRKTELKQMINTLHQHGLRVIL DVVFNHVYKRENSPFEKTVPGYFFRHDECGMPSNGTGVGNDIASERRMARKFIADCVV YWLEEYNVDGFRFDLLGILDIDTVLYMKEKATKAKPGILLFGEGWDLATPLPHEQKAA LANAPRMPGIGFFNDMFRDAVKGNTFHLKATGFALGNGESAQAVMHGIAGSSGWKALA PIVPEPSQSINYVESHDNHTFWDKMSFALPQENDSRKRSRQRLAAAIILLAQGVPFIH SGQEFFRTKQGVENSYQSSDSINQLDWDRRETFKEDVHYIRRLISLRKAHPAFRLRSA ADIQRHLECLTLKEHLIAYRLYDLDEVDEWKDIIVIHHASPDSVEWRLPNDIPYRLLC DPSGFQEDPTEIKKTVAVNGIGTVILYLASDLKSFA*" /label="amyX CDS" gene complement(2582229..2584385) /gene="amyX" /locus_tag="BSU_29930" /old_locus_tag="BSU29930" /label="amyX gene" Polymorphism join(2583926,2583928) /Source="geneious" /ID="SNP_BsDelta6_3063349_3063349" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position=459 /Change="A -> G" /Codon_Change="GTT -> GTC" /Coverage=168 /locus_tag="BSU_29930" /Protein_Effect="None" /Reference_Frequency="1.2%" /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value=0 /Variant_Raw_Frequency=165 /comment="silent" /modified_by="User" / /label="Polymorphism_Delta6" CDS complement(2584411..2585340) /gene="ytlR" /locus_tag="BSU_29940" /old_locus_tag="BSU29940" /EC_number="2.7.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phospholipid kinase" /protein_id="NP_390872.1" /db_xref="EnsemblGenomes-Gn:BSU29940" /db_xref="EnsemblGenomes-Tr:CAB14972" /db_xref="GOA:O34799" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13880" /db_xref="UniProtKB/Swiss-Prot:O34799" /translation="MSHWFFIINPTAGHRNGLRVWKSIQKELIKRKVEHRSFLTEHPG HAEVLARQISTIQEYKLKRLIVIGGDGTMHEVVNGLKDVDDIELSFVPAGAYNDFSRG FSIKKIDLIQEIKKVKRPLTRTFHLGSVNFLQDKSQILYFMNHIGIGFDAYVNKKAME FPLRRVFLFLRLRFLVYPLSHLHASATFKPFTLACTTEDETREFHDVWFAVVSNHPFY GGGMKAAPLANPREKTFDIVIVENQPFLKKYWLLCLMAFGKHTKMDGVTMFKAKDITF YTKDKIPFHADGEIMGTTPFRLASSPSPLRIKT*" /label="ytlR CDS" gene complement(2584411..2585340) /gene="ytlR" /locus_tag="BSU_29940" /old_locus_tag="BSU29940" /label="ytlR gene" CDS complement(2585389..2586303) /gene="ytlQ" /locus_tag="BSU_29950" /old_locus_tag="BSU29950" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390873.1" /db_xref="EnsemblGenomes-Gn:BSU29950" /db_xref="EnsemblGenomes-Tr:CAB14973" /db_xref="InterPro:IPR012397" /db_xref="SubtiList:BG13879" /db_xref="UniProtKB/Swiss-Prot:O34471" /translation="MAQIIKIHDYISRYELDPYHYINQFVRLKKERWLSLVEAAERQH EERQASAEEPEPVQKRKKFSLKRRKEEIKADIQEERHQWFEDEEDIHVRLPKSRVALA SFYKRHLYDFQLKWASSTLSEISQLSNQVKQDRILRYLTQQLPDSYFIMYKPVLKIQQ AAVELSIVIISPLEIYCVSFLEAEEDSVYIGSKNRFWDKKTASQTASVLNPGLSLFRT DSVVSKIVKEKQAEIPVRKLLLSRTSYIDYPEPPYGLEIADKRSAEEWIERQKKNTAP IKHHQVKAAKALLSYCMSDSYRRQEWLE*" /label="ytlQ CDS" gene complement(2585389..2586303) /gene="ytlQ" /locus_tag="BSU_29950" /old_locus_tag="BSU29950" /label="ytlQ gene" promotor_-10 complement(2586066..2586084) /Source="Nicolas_upshift_promotors" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-10" upshifts complement(2586074) /Source="Nicolas_upshifts" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="upshifts" promotor_-35 complement(2586098..2586104) /Source="Nicolas_upshift_promotors" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-35" CDS complement(2586329..2586880) /gene="ytlP" /locus_tag="BSU_29960" /old_locus_tag="BSU29960" /EC_number="3.1.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17012785; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA 2',3'-cyclic phosphodiesterase" /protein_id="NP_390874.1" /db_xref="EnsemblGenomes-Gn:BSU29960" /db_xref="EnsemblGenomes-Tr:CAB14974" /db_xref="GOA:O34570" /db_xref="InterPro:IPR004175" /db_xref="InterPro:IPR009097" /db_xref="SubtiList:BG13878" /db_xref="UniProtKB/Swiss-Prot:O34570" /translation="MPDIRPHYFIGVPIPEGIANPIYQAAKNEPILTFQKWVHPLDYH ITLIFLGAADETQIKKLEGSLAEIASEIDPFSIKFGKIDVFGDRRKPRVLHLEPKKNK TLDRLREHTKQAVLQAGFQVEKRPYHPHMTLARKWTGEDGFPAHVPFESGEVSMMAER FSLFQIHLNQSPKYEEIFKFQLS*" /label="ytlP CDS" gene complement(2586329..2586880) /gene="ytlP" /locus_tag="BSU_29960" /old_locus_tag="BSU29960" /label="ytlP gene" misc_feature 2586743..2586762 /Source="Nicolas_upshift_promotors" /id="U2325" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.962037962037962" /psig="0.996003996003996" /xcortree=2127 /SigmaFactorBS="tagcgaaccttcaagcttctttatttgtgtctcatccgccgc tccgagaaaaattaaCGTGATATGATAGTCAAGCGggtgcacccatttttgaaacgtc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2586746 /Source="Nicolas_upshifts" /id="U2325" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.962037962037962" /psig="0.996003996003996" /xcortree=2127 /SigmaFactorBS="tagcgaaccttcaagcttctttatttgtgtctcatccgccgc tccgagaaaaattaaCGTGATATGATAGTCAAGCGggtgcacccatttttgaaacgtc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2586903..2586922) /Source="Nicolas_upshift_promotors" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-10" upshifts complement(2586915) /Source="Nicolas_upshifts" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="upshifts" promotor_-35 complement(2586938..2586941) /Source="Nicolas_upshift_promotors" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-35" promotor_-35 2586963..2586970 /Source="Nicolas_upshift_promotors" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2586981..2587000 /Source="Nicolas_upshift_promotors" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2586984..2586995) /Source="Nicolas_upshift_promotors" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2586988 /Source="Nicolas_upshifts" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2586998) /Source="Nicolas_upshifts" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2587009..2587015) /Source="Nicolas_upshift_promotors" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2587029..2587964 /gene="ytkP" /locus_tag="BSU_29970" /old_locus_tag="BSU29970" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16267287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cysteine synthase-like enzyme" /protein_id="NP_390875.1" /db_xref="EnsemblGenomes-Gn:BSU29970" /db_xref="EnsemblGenomes-Tr:CAB14975" /db_xref="GOA:O34476" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR005856" /db_xref="InterPro:IPR005859" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG13872" /db_xref="UniProtKB/Swiss-Prot:O34476" /translation="MLKIVANTADLIGDTPLVRLNRLQPENAAQVYLKLEFFNPSGSV KDRAAYQMIIEAEQNGLLKPGSVIIEPTSGNTGIGLAMNAAARGYKAILVMPDTMTKE RINLLKAYGAEVVLTPGEERMPGSIKKAKELAEQIPNSYIPMQFDNTANPDAHRKTTA PEIARAIEEIGKPLGAFVASSGTGGTITGTGEALKELFPDITVHVVEPAGSPVLSGGK PGAHKLVGTSPGFIPPILNEDVYDEIIKISDEDAYTTTRRLAAEEGILVGPSSGAACF AAIETAKRLSPDKVVVCMTADTGERYLSTDLWSFI*" /label="ytkP CDS" gene 2587029..2587964 /gene="ytkP" /locus_tag="BSU_29970" /old_locus_tag="BSU29970" /label="ytkP gene" downshifts 2587940 /Source="Nicolas_upshifts" /id="D1544" /incds=0 /nref=74 /ntot=225 /MaxReadThrough="2.5873" /MaxDrop="4.59197" /score="29.2734118" /energy="-18.2" /TU="NA" /idTUdmin="U2327" /TUdmin="-16" /isTUend="TRUE" /label="downshifts" CDS complement(2587998..2589389) /gene="ytjP" /locus_tag="BSU_29980" /old_locus_tag="BSU29980" /EC_number="3.5.-.-" /EC_number="3.4.13.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7528082, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative promiscuous peptidase/deacylase" /protein_id="NP_390876.1" /db_xref="EnsemblGenomes-Gn:BSU29980" /db_xref="EnsemblGenomes-Tr:CAB14976" /db_xref="GOA:O34944" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010964" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13867" /db_xref="UniProtKB/Swiss-Prot:O34944" /translation="MNWEVEVIRKKEDLIRDTQEFLRINSVMDETTAGPGKPFGEGVN ASLTSLLELGEKEGFTTKNLDGFAGHIEWGEGDDIIGVLCHVDVVPPGDGWTSDPFSA EIRNGRIYARGAIDDKGPTMAAFYALKIVKDMNLPLSKRVRMIIGTDEESDWRCVEHY FKHEEMPTMGFAPDADFPIINAEKGIIDASLLIPHRPNQAEPKAVLVSFQSGLRLNMV PDAAEAVIEGPKNEEILSSFKDMLRTTDQKGEAAIENGQLILRMYGLSCHAMEPNNGI NAGILLCEFLQQTELDDAGKRFVQVVTDKFSGDTRGKKLDIDCEDEISGELTLNVGTL RYKEGQGGELGINIRYPVTAESKVIRDTFESASEFELGEFKDSKPHHVSADHPLVKTL QKVYEGQLGKKADLISIGGGTYARSLKAGVAFGPLFPGRPDSAHQKDEYIEIDDLLRS TALYAQAIYELAK*" /label="ytjP CDS" gene complement(2587998..2589389) /gene="ytjP" /locus_tag="BSU_29980" /old_locus_tag="BSU29980" /label="ytjP gene" downshifts complement(2588010) /Source="Nicolas_upshifts" /id="D1545" /incds=0 /nref=63 /ntot=240 /MaxReadThrough="3.38616" /MaxDrop="3.73023" /score="23.9099234" /energy="-14.4" /TU="U2330" /idTUdmin="U2330" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" S_feature complement(2589390..2589830) /Source="Nicolas_S_feature" /locus_tag="new_3068812_3069252_c" /HighExp="Etha, Salt, M40t90, Lbtran, T1.30H, M0t90, Lbstat, T1.0H, T0.30H, LBGstat" /AntisenseName="pbuO" /AntisenseCor="-0.324692399913451" /AntisenseRegPval="-7.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1149" promotor_-35 2589416..2589421 /Source="Nicolas_upshift_promotors" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2589435..2589454 /Source="Nicolas_upshift_promotors" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2589448 /Source="Nicolas_upshifts" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="upshifts" CDS 2589486..2590784 /gene="pbuO" /locus_tag="BSU_29990" /old_locus_tag="BSU29990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11591660, 12923093, 15849754, 16850406, 19446032, 28583948" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591660, 12923093, 15849754, 16850406, 19446032, 28583948; Product type t : transporter" /codon_start=1 /transl_table=11 /product="hypoxanthine/guanine permease" /protein_id="NP_390877.1" /db_xref="EnsemblGenomes-Gn:BSU29990" /db_xref="EnsemblGenomes-Tr:CAB14977" /db_xref="GOA:O34978" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR026033" /db_xref="SubtiList:BG13864" /db_xref="UniProtKB/Swiss-Prot:O34978" /translation="MFHLKEQQTSIKQEIIAGLTTFFTMVYIVVVNPVILANAGVPFD QVFTATIIASIVGTLWMALAANYPIAIAPGMGLNAYLAFHVVSASDGGITYATAFSAV FTAGVLFIILSLTPLRKQLIEAIPNNLKYGITTGIGLFIAFIGLRQAGIVAADESNLV TLGNLHSPGVILTLVGLLISVVLMVLNVSGALFIGMAATALIAFFTGQLHFSKGFMSL PHLPEGLMISNPFTAFGDVIHHGLYAVVFSFLLVTIFDTTGTMIGVAEQAGLMKNNKL PNVRKALLADSTATTVGAVFGTSPTTAFIESSAGVAAGGRTGLTALTVAVMFAASMFF SPLVSALSGIAAITSPALIIVGSLMMGSVSNMNWKEMDEAFPAFLVILAMPLTSSIST GIALGFISYPIVKAARGKWREIHPLVIVFAILFFIQLFIL*" /label="pbuO CDS" gene 2589486..2590784 /gene="pbuO" /locus_tag="BSU_29990" /old_locus_tag="BSU29990" /label="pbuO gene" promotor_-10 complement(2589807..2589826) /Source="Nicolas_upshift_promotors" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2589830) /Source="Nicolas_upshifts" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2589841..2589847) /Source="Nicolas_upshift_promotors" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2590771 /Source="Nicolas_upshifts" /id="D1546" /incds=0 /nref=43 /ntot=178 /MaxReadThrough="2.37859" /MaxDrop="5.35341" /score="16.9979166" /energy="-10.2" /TU="NA" /idTUdmin="U2329" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2590824..2591981) /gene="ythQ" /locus_tag="BSU_30000" /old_locus_tag="BSU30000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_390878.1" /db_xref="EnsemblGenomes-Gn:BSU30000" /db_xref="EnsemblGenomes-Tr:CAB14978" /db_xref="GOA:O35029" /db_xref="InterPro:IPR010288" /db_xref="SubtiList:BG13861" /db_xref="UniProtKB/Swiss-Prot:O35029" /translation="MNGRTLFFRRLFDYYKYQFKVLHAVIDWTVALYIVLPAIAFVIY QYIDLMNGRGLLYEWSEVAEWRWLYAVCVLIMFTGSIRTFLMEADKVFLLQKKEIIYQ LKRYALLYSFLATLAKWLLLFFIVLPLISHSVLITFAESTALLCYLFGLHIFFLSLKQ DRIRKPRSISRWIGDTLVRAILFAGSAILIVFTERHLLALFGILFLFFSVIRSLKKTA SFTAFEAEVTEEKKSRLALAGLVMMMSQEAGMPKVKDRMRRKPLLYRNSKRIFKRRTI CTGYKELFFKVMLRNGEYARQMYMLLSAFTVLIFVSPIWLKVIALLVYTGVCRYILTL IFDKVMDAPFLIGTDKESDEYYRARKSCINILHYAFAACCFLAAAVSLLFT*" /label="ythQ CDS" gene complement(2590824..2591981) /gene="ythQ" /locus_tag="BSU_30000" /old_locus_tag="BSU30000" /label="ythQ gene" downshifts complement(2590849) /Source="Nicolas_upshifts" /id="D1547" /incds=0 /nref=1 /ntot=153 /MaxReadThrough="3.07175" /MaxDrop="3.89104" /score="19.8243425" /energy="-11.2" /TU="NA" /idTUdmin="U2332" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2591097..2591102 /Source="Nicolas_upshift_promotors" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2591117..2591135 /Source="Nicolas_upshift_promotors" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2591125 /Source="Nicolas_upshifts" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2591978..2592688) /gene="ythP" /locus_tag="BSU_30010" /old_locus_tag="BSU30010" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_390879.1" /db_xref="EnsemblGenomes-Gn:BSU30010" /db_xref="EnsemblGenomes-Tr:CAB14979" /db_xref="GOA:O34977" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13860" /db_xref="UniProtKB/Swiss-Prot:O34977" /translation="MTNLLEASIEQAGYTSRKKVLTDVFLEVRKGELVGLIGANGAGK STAIKAILGLSEDFKGHIAWNDCSFAYIPEHPSFYEELTLWEHLDLISTLHGIEESEF AHRAQSLLQTFSLDHVKHELPVTFSKGMQQKLMLIQAFLSKPDMYVIDEPFIGLDPIS TKRFVDMLKAEKERGAGILMCTHVLDTAEKICDRFYMIEKGSLFLQGTLKDVQDKTGL EGQSLLDCFYKAVQGDRL*" /label="ythP CDS" gene complement(2591978..2592688) /gene="ythP" /locus_tag="BSU_30010" /old_locus_tag="BSU30010" /label="ythP gene" promotor_-10 complement(2592702..2592717) /Source="Nicolas_upshift_promotors" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2592719) /Source="Nicolas_upshifts" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2592729..2592738) /Source="Nicolas_upshift_promotors" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2592745..2592746 /Source="Nicolas_upshift_promotors" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2592758..2592863 /Source="Nicolas_S_feature" /locus_tag="new_3072180_3072285" /HighExp="S5, S4, S3, S8, S7, S6, G/S, Pyr, T5.0H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.583" /TUlongSig="NA" /TUlongPSig="NA" /label="S1150" upshifts 2592758 /Source="Nicolas_upshifts" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2592766..2592776 /Source="Nicolas_upshift_promotors" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2592829..2592835 /Source="Nicolas_upshift_promotors" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2592850..2592869 /Source="Nicolas_upshift_promotors" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2592865..2592978 /Source="Nicolas_S_feature" /locus_tag="new_3072287_3072400" /HighExp="S4, S5, M0t90, S3, Etha, M9-stat, M40t90, LPhT, Heat, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.583" /TUlongSig="NA" /TUlongPSig="NA" /label="S1151" upshifts 2592865 /Source="Nicolas_upshifts" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="upshifts" CDS 2592979..2593200 /gene="ytzE" /locus_tag="BSU_30020" /old_locus_tag="BSU30020" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12618461; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (DeoR family)" /protein_id="NP_390880.1" /db_xref="EnsemblGenomes-Gn:BSU30020" /db_xref="EnsemblGenomes-Tr:CAB14980" /db_xref="GOA:O32067" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13939" /db_xref="UniProtKB/Swiss-Prot:O32067" /translation="MKPSTNRMLTRIKSVYMFIQEKGLVTTQELVDEFGITPRTIQRD LNVLAYNDLVHSPSRGKWETTRKKVKITS*" /label="ytzE CDS" gene 2592979..2593200 /gene="ytzE" /locus_tag="BSU_30020" /old_locus_tag="BSU30020" /label="ytzE gene" downshifts 2593183 /Source="Nicolas_upshifts" /id="D1548" /incds=0 /nref=166 /ntot=259 /MaxReadThrough="4.38243" /MaxDrop="4.90218" /score="20.9755494" /energy="-13.5" /TU="U2333,U2334" /idTUdmin="U2333" /TUdmin="-54" /isTUend="FALSE" /label="downshifts" downshifts 2593252 /Source="Nicolas_upshifts" /id="D1549" /incds=0 /nref=44 /ntot=172 /MaxReadThrough="-0.189589999999999" /MaxDrop="6.00369" /score="20.9755494" /energy="-13.5" /TU="NA" /idTUdmin="U2334" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2593321..2594040) /gene="rsuA" /locus_tag="BSU_30035" /old_locus_tag="BSU30035" /EC_number="4.2.1.70" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11953756, 16511038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA pseudouridylate 516 synthase" /protein_id="NP_390882.2" /db_xref="EnsemblGenomes-Gn:BSU30035" /db_xref="EnsemblGenomes-Tr:CAB14982" /db_xref="GOA:O32068" /db_xref="InterPro:IPR000748" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR018496" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG13941" /db_xref="UniProtKB/Swiss-Prot:O32068" /translation="MRLDKLLANSGYGSRKEVKAVVKAGAVMIDGKPAKDVKEHVDPD TQEVTVYGEPVDYREFIYLMMNKPQGVLSATEDSRQQTVVDLLTPEEMRFEPFPAGRL DKDTEGFLLLTNDGQLAHRLLSPKKHVPKTYEVHLKSQISREDISDLETGVYIEGGYK TKPAKAEIKTNDSGNTVIYLTITEGKYHQVKQMAKAVGNEVVYLKRLSMGRVSLDPAL APGEYRELTEEELHLLNEPQA*" /label="rsuA CDS" gene complement(2593321..2594040) /gene="rsuA" /locus_tag="BSU_30035" /old_locus_tag="BSU30035" /label="rsuA gene" downshifts complement(2593335) /Source="Nicolas_upshifts" /id="D1550" /incds=0 /nref=1 /ntot=49 /MaxReadThrough="0.79865" /MaxDrop="2.6873" /score="21.6808891" /energy="-13.5" /TU="NA" /idTUdmin="U2335" /TUdmin=154 /isTUend="FALSE" /label="downshifts" downshifts complement(2594106) /Source="Nicolas_upshifts" /id="D1551" /incds=0 /nref=1 /ntot=76 /MaxReadThrough="4.50848" /MaxDrop="2.99899" /score="8.79816042" /energy="-9.5" /TU="U2335" /idTUdmin="U2335" /TUdmin="-617" /isTUend="FALSE" /label="downshifts" CDS complement(2594109..2595743) /gene="murJ" /locus_tag="BSU_30050" /old_locus_tag="BSU30050" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11254558, 15044829, 15849754, 16850406, 19648239, 25918422, 27537185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11254558, 15044829, 15849754, 16850406, 19648239, 25918422, 27537185; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipid II flippase" /protein_id="NP_390883.1" /db_xref="EnsemblGenomes-Gn:BSU30050" /db_xref="EnsemblGenomes-Tr:CAB14983" /db_xref="GOA:O34674" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG13856" /db_xref="UniProtKB/Swiss-Prot:O34674" /translation="MSSKLLRGTFVLTLGTYISRILGMVYLIPFSIMVGATGGALFQY GYNQYTLFLNIATMGFPAAVSKFVSKYNSKGDYETSRKMLKAGMSVMLVTGMIAFFIL YLSAPMFAEISLGGKDNNGLTIDHVVYVIRMVSLALLVVPIMSLVRGFFQGHQMMGPT AVSQVVEQIVRIIFLLSATFLILKVFNGGLVIAVGYATFAALIGAFGGLVVLYIYWNK RKGSLLAMMPNTGPTANLSYKKMFFELFSYAAPYVFVGLAIPLYNYIDTNTFNKAMIE AGHQAISQDMLAILTLYVQKLVMIPVSLATAFGLTLIPTITESFTSGNYKLLNQQINQ TMQTILFLIIPAVVGISLLSGPTYTFFYGSESLHPELGANILLWYSPVAILFSLFTVN AAILQGINKQKFAVVSLVIGVVIKLVLNVPLIKLMQADGAILATALGYIASLLYGFIM IKRHAGYSYKILVKRTVLMLVLSAIMGIAVKIVQWVLGFFISYQDGQMQAAIVVVIAA AVGGAVYLYCGYRLGFLQKILGRRLPGFFRKGRHAG*" /label="murJ CDS" gene complement(2594109..2595743) /gene="murJ" /locus_tag="BSU_30050" /old_locus_tag="BSU30050" /label="murJ gene" misc_feature complement(2595775..2595794) /Source="Nicolas_upshift_promotors" /id="U2335" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=2597 /SigmaFactorBS="gcggacatgaatgttcacaggattgcttttgtatttattacc gtctaaatgcccagtTGTGGTAAAATAGAAAAGTTgaatcttcgtagaaaatggtgat g" /listShort="ytgP, ytzG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2595791) /Source="Nicolas_upshifts" /id="U2335" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=2597 /SigmaFactorBS="gcggacatgaatgttcacaggattgcttttgtatttattacc gtctaaatgcccagtTGTGGTAAAATAGAAAAGTTgaatcttcgtagaaaatggtgat g" /listShort="ytgP, ytzG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2595861..2595865 /Source="Nicolas_upshift_promotors" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2595881..2595900 /Source="Nicolas_upshift_promotors" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2595899 /Source="Nicolas_upshifts" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="upshifts" CDS 2595945..2597207 /gene="ytfP" /locus_tag="BSU_30060" /old_locus_tag="BSU30060" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(FAD)-utilizing dehydrogenase" /protein_id="NP_390884.2" /db_xref="EnsemblGenomes-Gn:BSU30060" /db_xref="EnsemblGenomes-Tr:CAB14984" /db_xref="InterPro:IPR004792" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13850" /db_xref="UniProtKB/Swiss-Prot:Q795R8" /translation="MKQYDVIVIGGGPSGLMAAIAAGEQGAGVLLIDKGNKLGRKLAI SGGGRCNVTNRLPVEEIIKHIPGNGRFLYSAFSEFNNEDIIKFFENLGIQLKEEDHGR MFPVTDKAQSVVDALLNRLKQLRVTIRTNEKIKSVLYEDGQAAGIVTNNGEMIHSQAV IIAVGGKSVPHTGSTGDGYEWAEAAGHTITELFPTEVPVTSGEPFIKQKTLQGLSLRD VAVSVLNKKGKPIITHKMDMLFTHFGLSGPAILRCSQFVVKELKKQPQVPIRIDLYPD INEETLFQKMYKELKEAPKKTIKNVLKPWMQERYLLFLLEKNGISPNVSFSELPKDPF RQFVRDCKQFTVLANGTLSLDKAFVTGGGVSVKEIDPKKMASKKMEGLYFCGEILDIH GYTGGYNITSALVTGRLAGLNAGQYARS*" /label="ytfP CDS" gene 2595945..2597207 /gene="ytfP" /locus_tag="BSU_30060" /old_locus_tag="BSU30060" /label="ytfP gene" S_feature 2597208..2597306 /Source="Nicolas_S_feature" /locus_tag="new_3076630_3076728" /HighExp="LBGstat, Lbstat, M0t90, T2.30H, T1.0H, T0.30H, BC, T2.0H, T1.30H, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1152" promotor_-35 2597280..2597286 /Source="Nicolas_upshift_promotors" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2597302..2597320 /Source="Nicolas_upshift_promotors" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2597308..2597395 /Source="Nicolas_S_feature" /locus_tag="new_3076730_3076817" /HighExp="Etha, LBGstat, Salt, M9-stat, Lbstat, LBGtran, Sw, C30, Gly, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.996, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1153" upshifts 2597308 /Source="Nicolas_upshifts" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="upshifts" CDS 2597396..2598934 /gene="opuD" /locus_tag="BSU_30070" /old_locus_tag="BSU30070" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14996799, 15849754, 16850406, 8752321, 9925583" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14996799, 15849754, 16850406, 8752321, 9925583; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycine betaine transporter" /protein_id="NP_390885.1" /db_xref="EnsemblGenomes-Gn:BSU30070" /db_xref="EnsemblGenomes-Tr:CAB14985" /db_xref="GOA:P54417" /db_xref="InterPro:IPR000060" /db_xref="InterPro:IPR018093" /db_xref="SubtiList:BG11958" /db_xref="UniProtKB/Swiss-Prot:P54417" /translation="MLKHISSVFWIVIAITAAAVLWGVISPDSLQNVSQSAQAFITDS FGWYYLLVVSLFVGFCLFLIFSPIGKIKLGKPDEKPEFGLLSWFAMLFSAGMGIGLVF YGAAEPISHYAISSPSGETETPQAFRDALRYTFFHWGLHAWAIYAIVALCIAYFQFRK GAPGLISSTLSPILGDKVNGPIGKAIDCIAVFATVVGVSTSLGLGATQINGGLNYLFG IPNAFIVQLVLIIIVTVLFLLSAWSGLGKGIKYLSNTNMVLAGLLMLFMLVVGPTVLI MNSFTDSIGQYIQNIVQMSFRLTPNDPEKREWINSWTIFYWAWWISWSPFVGIFIARV SRGRTIREFLIGVLVTPCILTFLWFSIFGVSAMDLQQKGAFNVAKLSTETMLFGTLDH YPLTMVTSILALILIAVFFITSADSATFVLGMQTSYGSLNPANSVKLSWGIIQSAMAA VLLYSGGLAALQNTAILAALPFSIVILLMIASLYQSLSKERREIKKAEKLDKPRSPRV KKAY*" /label="opuD CDS" gene 2597396..2598934 /gene="opuD" /locus_tag="BSU_30070" /old_locus_tag="BSU30070" /label="opuD gene" downshifts 2598914 /Source="Nicolas_upshifts" /id="D1552" /incds=0 /nref=231 /ntot=263 /MaxReadThrough="2.0688" /MaxDrop="6.06429" /score="27.1497809" /energy="-16.3" /TU="NA" /idTUdmin="U2336" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2598971..2599153) /gene="yteV" /locus_tag="BSU_30080" /old_locus_tag="BSU30080" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 8990290" /codon_start=1 /transl_table=11 /product="conserved sporulation-related protein" /protein_id="NP_390886.1" /db_xref="EnsemblGenomes-Gn:BSU30080" /db_xref="EnsemblGenomes-Tr:CAB14986" /db_xref="GOA:P94496" /db_xref="InterPro:IPR020296" /db_xref="SubtiList:BG12339" /db_xref="UniProtKB/Swiss-Prot:P94496" /translation="MLKVAVFDEEHEKDLQTEINSFLKGISEEQLIDIKYTVSAACDP DGEQLYCFSALILYRK*" /label="yteV CDS" gene complement(2598971..2599153) /gene="yteV" /locus_tag="BSU_30080" /old_locus_tag="BSU30080" /label="yteV gene" downshifts complement(2598990) /Source="Nicolas_upshifts" /id="D1553" /incds=0 /nref=10 /ntot=61 /MaxReadThrough="0.597819999999999" /MaxDrop="4.78152" /score="32.507978" /energy="-16.3" /TU="NA" /idTUdmin="U2338" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2599168..2599186) /Source="Nicolas_upshift_promotors" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2599188) /Source="Nicolas_upshifts" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2599202..2599207) /Source="Nicolas_upshift_promotors" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2599221..2599889) /gene="rmgU" /locus_tag="BSU_30090" /old_locus_tag="BSU30090" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17449691, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane enzyme for rhamnogalaturonan degradation" /protein_id="NP_390887.1" /db_xref="EnsemblGenomes-Gn:BSU30090" /db_xref="EnsemblGenomes-Tr:CAB14987" /db_xref="GOA:O34378" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG13846" /db_xref="UniProtKB/Swiss-Prot:O34378" /translation="MEHDGSLGRMLRFCEWIMRFAYTNLLWLFFTLLGLGVFGIMPAT AALFAVMRKWIQGQDNVPVLKTFWQEYKGEFFRSNLLGAVLALIGVIIYIDLALIYPS HFLLHILRFAIMIFGFLFVSMLFYVFPLLVHFDWKKRLYVKFSLLLSVAYLQYTLTML ALTVALFFLLAYLPGIVPFFSVSLISYCHMRIVYAVLLKVEQHGGEPQRKSHIRKAFY PETR*" /label="rmgU CDS" gene complement(2599221..2599889) /gene="rmgU" /locus_tag="BSU_30090" /old_locus_tag="BSU30090" /label="rmgU gene" CDS complement(2599911..2601197) /gene="rmgT" /locus_tag="BSU_30100" /old_locus_tag="BSU30100" /EC_number="1.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17449691, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase of rhamnogalaturonan degradation" /protein_id="NP_390888.1" /db_xref="EnsemblGenomes-Gn:BSU30100" /db_xref="EnsemblGenomes-Tr:CAB14988" /db_xref="GOA:O34371" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13845" /db_xref="UniProtKB/Swiss-Prot:O34371" /translation="MKNIVFCGLSSRAFSMFIKPLMERFSTHYEITGLLDADPKRFAV CKKKFPELAHVPEFSEDAFDEMMRVSKPDIVIVAGRDDTHVAYIVKSLQWNTDVITEK PMVTTVQDANRVLEAEAKSEGKVTVAFNYRYSPFHRKIKEMILDGKIGRVTSVDLNWY IDTYHGASYFKRWNRSRQFSGGLSVHKSTHHFDLVNWWLGQNPEEVFAYGALNYYGPD SEWNPLPEEDGRFCGTCRVKEKCHYYSRWHPRSSKASIKDDHLEAGDQSSLYTAYRPD ACIFDEEIDIEDTYVAAVKYDGGALLSYSIIFSAPYEGYRLTINGTKGRIESNEFHEP SRIPFAFPEQTIEYYPLFESKQTIQVVKNEGGHGGGDPLLLEDLFLGKDPLRRYDILA GAEAGAYSIAVGEGMWRSVAEKKPIGMKELFQMQNV*" /label="rmgT CDS" gene complement(2599911..2601197) /gene="rmgT" /locus_tag="BSU_30100" /old_locus_tag="BSU30100" /label="rmgT gene" CDS complement(2601209..2601712) /gene="rmgS" /locus_tag="BSU_30110" /old_locus_tag="BSU30110" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17449691, 23504016; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein required for rhamnogalaturonan transport and degradation" /protein_id="NP_390889.2" /db_xref="EnsemblGenomes-Gn:BSU30110" /db_xref="EnsemblGenomes-Tr:CAB14989" /db_xref="GOA:C0SP80" /db_xref="SubtiList:BG13844" /db_xref="UniProtKB/Swiss-Prot:C0SP80" /translation="MTKRIRTALCVIVSVLFLASCSSRPDGMHVILFSDMQAGVQEKI KKAAEQNAGKVDIFPAFQEKLLTEITAHEGDVFIVPEDMFQAYDDPENFQPLNGLPPE KTSPYTTVNKKTGEKTIYAVQIEKGKKQLNGYSFQLNRDMAAFIPVYAEKTEEALQLI SQLTEAR*" /label="rmgS CDS" gene complement(2601209..2601712) /gene="rmgS" /locus_tag="BSU_30110" /old_locus_tag="BSU30110" /label="rmgS gene" CDS complement(2601709..2602830) /gene="rmgQ" /locus_tag="BSU_30120" /old_locus_tag="BSU30120" /EC_number="3.2.1.172" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15148314, 15906318, 16781735, 16870154, 17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15148314, 15906318, 16781735, 16870154, 17449691, 23504016; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="unsaturated rhamnogalacturonyl hydrolase" /protein_id="NP_390890.3" /db_xref="EnsemblGenomes-Gn:BSU30120" /db_xref="EnsemblGenomes-Tr:CAB14990" /db_xref="GOA:O34559" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR010905" /db_xref="PDB:1NC5" /db_xref="PDB:2D8L" /db_xref="PDB:2GH4" /db_xref="SubtiList:BG13843" /db_xref="UniProtKB/Swiss-Prot:O34559" /translation="MGSMDQSIAVKSPLTYAEALANTIMNTYTVEELPPANRWHYHQG VFLCGVLRLWEATGEKRYFEYAKAYADLLIDDNGNLLFRRDELDAIQAGLILFPLYEQ TKDERYVKAAKRLRSLYGTLNRTSEGGFWHKDGYPYQMWLDGLYMGGPFALKYANLKQ ETELFDQVVLQESLMRKHTKDAKTGLFYHAWDEAKKMPWANEETGCSPEFWARSIGWY VMSLADMIEELPKKHPNRHVWKNTLQDMIKSICRYQDKETGLWYQIVDKGDRSDNWLE SSGSCLYMYAIAKGINKGYLDRAYETTLLKAYQGLIQHKTETSEDGAFLVKDICVGTS AGFYDYYVSRERSTNDLHGAGAFILAMTELEPLFRSAGK*" /label="rmgQ CDS" gene complement(2601709..2602830) /gene="rmgQ" /locus_tag="BSU_30120" /old_locus_tag="BSU30120" /label="rmgQ gene" CDS complement(2602838..2603803) /gene="rmgP" /locus_tag="BSU_30135" /old_locus_tag="BSU30135" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691, 23504016; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease for unsaturated rhamnogalacturonan" /protein_id="NP_390892.2" /db_xref="EnsemblGenomes-Gn:BSU30135" /db_xref="EnsemblGenomes-Tr:CAB14992" /db_xref="GOA:C0SPB3" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13841" /db_xref="UniProtKB/Swiss-Prot:C0SPB3" /translation="MKTAEAQAPAVDAVIFKKEKRKRLLIKLIQQKYLYLMILPGCIY FLLFKYVPMWGIVIAFQDYQPFLGILGSEWVGLKHFIRLFTEPTFFLLLKNTLVLFAL NLAIFFPVPILLALLLNEVRIALFKKFVQTLIYIPHFMSWVIVVSLSFVLLTVDGGLI NELIVFFGGEKINFLLNEEWFRPLYILQVIWREAGWSTIIYLAAITAVDPQLYEAAKM DGAGRLRQMWHITLPAIKSVIVVLLILKIGDTLELGFEHVYLLLNATNREVAEIFDTY VYTAGLKQGQFSYSTAVGVFKAAVGLILVMLANRLAKKFGEEGIY*" /label="rmgP CDS" gene complement(2602838..2603803) /gene="rmgP" /locus_tag="BSU_30135" /old_locus_tag="BSU30135" /label="rmgP gene" upshifts complement(2603829) /Source="Nicolas_upshifts" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2603830..2603849) /Source="Nicolas_upshift_promotors" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2603864..2603871) /Source="Nicolas_upshift_promotors" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2603959..2603966 /Source="Nicolas_upshift_promotors" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2603979 /Source="Nicolas_upshifts" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2603982..2604001 /Source="Nicolas_upshift_promotors" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2604019..2606337 /gene="rmgR" /locus_tag="BSU_30150" /old_locus_tag="BSU30150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="membrane bound transcriptional regulator (controlling rhamnogalacturonan degradation)" /protein_id="NP_390893.1" /db_xref="EnsemblGenomes-Gn:BSU30150" /db_xref="EnsemblGenomes-Tr:CAB14993" /db_xref="GOA:O32071" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG13838" /db_xref="UniProtKB/Swiss-Prot:O32071" /translation="MGGFMKRSQYKFYYKLITFFCLLSTIPVILVGLFSYEHSQKTAI SNVSEEKFDTLQQTQQSIEHILKTVDHSLTHYVSSPPLLRTLSEPLHSDQFQIYNQVN QELNYLQSFDTDLSNMTLVSYTKKWYMNNSGLYRLNTDTLHEAASAYTKQKASRSYWT LEENNHLISTKEGTAENCRYNINLIKQLPLNSTNTKGLAAASIPSCSLVKNMPGYSNA NNLFIIDEKGLIILHNNMSDVGESLHNDGFVQKVLAQTANSGQFETVIDRIHYKVTYQ KSDYNAWTYFSLVSLPELKKEAKSIGWITFAVCLILLTLSLLFSWLGSRHFYKPIRVL YESFARHGAIQEKQQPPQNEFELIEQSFKQLKDRNDDLEETMKQQATHLQQYFMVRLM LGKLTDEEVDNRFESLGLKQNWRHLALLVLQIDTLNHTPYEKKDMDLLLFAVNSLIER NIPTDKHLAPAVVDKQQATILINQSGTKEEFMAELNETARMIQEKAEAELQLSVSIGI SQPFDVLTKAKTAYAEGSEALKYRLKAENKSIIFYEDLDQKKTFKTHFPKQLQHELFD AVKAGDKEKADKCLHAILQAIFTQNTNPYQFQIAIARFLNHVIELMHVLGIELFELEE NKMLYDQIFELKTFEDTENWLKNEFIDPMTDKVNARADAQYKNISDNIIHIIHHEFES ELTLDEIARRLHYNPNYLSSIFKKEMGISFSEYVSSYRHHMAKSWLAETDMAVKDIAE KLKYKNSQNFIRSFKKLEGITPGNYRQQKRSM*" /label="rmgR CDS" gene 2604019..2606337 /gene="rmgR" /locus_tag="BSU_30150" /old_locus_tag="BSU30150" /label="rmgR gene" downshifts 2606327 /Source="Nicolas_upshifts" /id="D1554" /incds=0 /nref=8 /ntot=42 /MaxReadThrough="1.43431" /MaxDrop="3.6268" /score="-7.37324741" /energy="-10.2" /TU="NA" /idTUdmin="U2340" /TUdmin=1870 /isTUend="FALSE" /label="downshifts" CDS complement(2606378..2607874) /gene="ytcQ" /locus_tag="BSU_30160" /old_locus_tag="BSU30160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative ABC transporter (binding lipoprotein)" /protein_id="NP_390894.3" /db_xref="EnsemblGenomes-Gn:BSU30160" /db_xref="EnsemblGenomes-Tr:CAB14994" /db_xref="GOA:Q795R2" /db_xref="SubtiList:BG13836" /db_xref="UniProtKB/Swiss-Prot:Q795R2" /translation="MGNKWRVLLIVLVLALGGVLAGCKGTDQSSAEGKAGPDSKVKLS WMAILYHQQPPKDRAIKEIEKLTNTELDITWVPDAVKEDRLNAALAAGNLPQIVTIQD IKNSSVMNAFRSGMFWEIGDYIKDYPNLNKMNKLINKNVTIDGKLYGIYRERPLSRQG IVIRKDWLDNLNLKTPKTLDELYEVAKAFTEDDPDKDGKDDTFGLADRNDLIYGAFKT IGSYEGMPTDWKESGGKFTPDFMTQEYKDTMNYMKKLRDNGYMNKDFPVTSKTQQQEL FSQGKAGIYIGNMVDAVNLRDHASDKSMKLEIINRIKGPDGKERVWASGGHNGVFAFP KTSVKTEAELKRILAFFDRIAEEDVYSLMTYGIDGVHYNKGEDKTFTRKESQVKDWQT DIQPLSALIAIDKAYLKNTGDPLRTAYEELTEDNEKIIVSNPAESLYSASESERGDEL KKIIDDATYKYMIGDITESQFDKEVEKWESSGGKQIIQEYEEAFKQAK*" /label="ytcQ CDS" gene complement(2606378..2607874) /gene="ytcQ" /locus_tag="BSU_30160" /old_locus_tag="BSU30160" /label="ytcQ gene" downshifts complement(2606380) /Source="Nicolas_upshifts" /id="D1555" /incds=0 /nref=26 /ntot=160 /MaxReadThrough="-0.0485899999999999" /MaxDrop="5.21039" /score="6.31011081" /energy="-11.2" /TU="NA" /idTUdmin="U2341" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2607899..2608759) /gene="ytcP" /locus_tag="BSU_30170" /old_locus_tag="BSU30170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_390895.1" /db_xref="EnsemblGenomes-Gn:BSU30170" /db_xref="EnsemblGenomes-Tr:CAB14995" /db_xref="GOA:P53561" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11788" /db_xref="UniProtKB/Swiss-Prot:P53561" /translation="MKNRLFDMLIYGFLLMFALICVLPFIHVIAASFATVEEVVSKKF ILIPTTFSLDAYRYIFSTDIIYKSLLVSVFVTVIGTAVSMFLSSLMAYGLSRRDLIGR QPLMFLVVFTMLFSGGMIPTFLVVKSLGLLDSYWALILPTAINAFNLIILKNFFQNIP SSLEESAKIDGCNDLGIFFKIVLPLSLPAIATISLFYAVTYWNTYMTAILYLNDSAKW PIQVLLRQIVIVSSGMQGDMSEMGSGSPPPEQTIKMAVIVVATIPVLLVYPFIQKHFA KGALLGSVKG*" /label="ytcP CDS" gene complement(2607899..2608759) /gene="ytcP" /locus_tag="BSU_30170" /old_locus_tag="BSU30170" /label="ytcP gene" promotor_-10 complement(2608835..2608854) /Source="Nicolas_upshift_promotors" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2608844) /Source="Nicolas_upshifts" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2608870..2608877) /Source="Nicolas_upshift_promotors" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2608966..2609727) /gene="ytbQ" /locus_tag="BSU_30180" /old_locus_tag="BSU30180" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-dependent nucleoside-diphosphate-sugar epimerase" /protein_id="NP_390896.2" /db_xref="EnsemblGenomes-Gn:BSU30180" /db_xref="EnsemblGenomes-Tr:CAB14996" /db_xref="GOA:P53560" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11787" /db_xref="UniProtKB/Swiss-Prot:P53560" /translation="MKKVLIAGGNGVIGRLLAEGLISDYEVTVLDKDHFDGKASSIQA DAANYEELLKKIPKDTDAILNLLAVKIKYDIMDIAEFEKMTDVFYRASYYLCRAAAEL GIQKLVFASSNHVTDVYEKDGRSLLGREITTSDYPLSKNLYGVLKLTSEQIGHLFYLE NKLSVINLRIGTVVTDEMDTLHEKERTKKTLLSHPDLLSIFKAAIETNIRYGTYYAVS DNPGRPWSIESAVNELGFSPQINTAELLNEEENGA*" /label="ytbQ CDS" gene complement(2608966..2609727) /gene="ytbQ" /locus_tag="BSU_30180" /old_locus_tag="BSU30180" /label="ytbQ gene" downshifts complement(2608995) /Source="Nicolas_upshifts" /id="D1556" /incds=0 /nref=153 /ntot=196 /MaxReadThrough="1.18543" /MaxDrop="5.85654" /score="12.3836957" /energy="-11.1" /TU="NA" /idTUdmin="U2344" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" S_feature complement(2609728..2609803) /Source="Nicolas_S_feature" /locus_tag="new_3089150_3089225_c" /HighExp="LPh, HPh, aero, Gly, HiOs, BMM, GM-0.1, GM 10, GM 15, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1154" CDS complement(2609804..2610991) /gene="bioI" /locus_tag="BSU_30190" /old_locus_tag="BSU30190" /EC_number="1.14.14.46" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11368323, 11472016, 12943422, 20658980, 21435937, 21437340, 28196402" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11368323, 11472016, 12943422, 20658980, 21435937, 21437340, 28196402; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 for pimelic acid formation for biotin biosynthesis" /protein_id="NP_390897.1" /db_xref="EnsemblGenomes-Gn:BSU30190" /db_xref="EnsemblGenomes-Tr:CAB14997" /db_xref="GOA:P53554" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="PDB:3EJB" /db_xref="PDB:3EJD" /db_xref="PDB:3EJE" /db_xref="SubtiList:BG11528" /db_xref="UniProtKB/Swiss-Prot:P53554" /translation="MTIASSTASSEFLKNPYSFYDTLRAVHPIYKGSFLKYPGWYVTG YEETAAILKDARFKVRTPLPESSTKYQDLSHVQNQMMLFQNQPDHRRLRTLASGAFTP RTTESYQPYIIETVHHLLDQVQGKKKMEVISDFAFPLASFVIANIIGVPEEDREQLKE WAASLIQTIDFTRSRKALTEGNIMAVQAMAYFKELIQKRKRHPQQDMISMLLKGREKD KLTEEEAASTCILLAIAGHETTVNLISNSVLCLLQHPEQLLKLRENPDLIGTAVEECL RYESPTQMTARVASEDIDICGVTIRQGEQVYLLLGAANRDPSIFTNPDVFDITRSPNP HLSFGHGHHVCLGSSLARLEAQIAINTLLQRMPSLNLADFEWRYRPLFGFRALEELPV TFE*" /label="bioI CDS" gene complement(2609804..2610991) /gene="bioI" /locus_tag="BSU_30190" /old_locus_tag="BSU30190" /label="bioI gene" CDS complement(2611060..2612067) /gene="bioB" /locus_tag="BSU_30200" /old_locus_tag="BSU30200" /EC_number="2.8.1.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110099, 8763940, 11717296, 12368242" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110099, 8763940, 11717296, 12368242; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin synthase" /protein_id="NP_390898.1" /db_xref="EnsemblGenomes-Gn:BSU30200" /db_xref="EnsemblGenomes-Tr:CAB14998" /db_xref="GOA:P53557" /db_xref="InterPro:IPR002684" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010722" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024177" /db_xref="SubtiList:BG11525" /db_xref="UniProtKB/Swiss-Prot:P53557" /translation="MNQWMELADRVLAGAEVTDEEALSILHCPDEDILLLMHGAFHIR KHFYGKKVKLNMIMNAKSGLCPENCGYCSQSAISKAPIESYRMVNKETLLEGAKRAHD LNIGTYCIVASGRGPSNREVDQVVDAVQEIKETYGLKICACLGLLKPEQAKRLKDAGV DRYNHNLNTSQRNHSNITTSHTYDDRVNTVEIAKESGLSPCSGAIIGMKETKQDVIDI AKSLKALDADSIPVNFLHAIDGTPLEGVNELNPLYCLKVLALFRFINPSKEIRISGGR EVNLRTLQPLGLYAANSIFVGDYLTTAGQEETEDHKMLSDLGFEVESVEEMKASLSAK S*" /label="bioB CDS" gene complement(2611060..2612067) /gene="bioB" /locus_tag="BSU_30200" /old_locus_tag="BSU30200" /label="bioB gene" CDS complement(2612070..2612765) /gene="bioD" /locus_tag="BSU_30210" /old_locus_tag="BSU30210" /EC_number="6.3.3.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110099, 8763940, 11717296, 12368242, 20565114" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110099, 8763940, 11717296, 12368242, 20565114; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dethiobiotin synthetase" /protein_id="NP_390899.1" /db_xref="EnsemblGenomes-Gn:BSU30210" /db_xref="EnsemblGenomes-Tr:CAB14999" /db_xref="GOA:P53558" /db_xref="InterPro:IPR004472" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11526" /db_xref="UniProtKB/Swiss-Prot:P53558" /translation="MRGFFVTGTDTEVGKTVISSGLAALLKDNNRHVGVYKPFLSGIS RHHPDSDTSLLKDMSQTSLSHEDITPFAFKAPLAPYVAGKLEGKTVTMEEVLSHWGRI REKHECFIVEGAGGISVPLGEDYLVSHVIKALQLPMIIVARPRLGTINHTFLTVKYAE SMGLPIAGIIINGISDSPDEDEKTNPEMIERLCGVPILGVTPKLANVTKETVLHMVKD HINLSLLMNQVGV*" /label="bioD CDS" gene complement(2612070..2612765) /gene="bioD" /locus_tag="BSU_30210" /old_locus_tag="BSU30210" /label="bioD gene" CDS complement(2612762..2613931) /gene="bioFC" /locus_tag="BSU_30220" /old_locus_tag="BSU30220" /EC_number="2.3.1.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8763940, 11322938, 11717296, 12368242, 15056910, 16557306" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763940, 11322938, 11717296, 12368242, 15056910, 16557306; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="8-amino-7-oxononanoate synthase (pimeloyl-CoA-dependent)" /protein_id="NP_390900.1" /db_xref="EnsemblGenomes-Gn:BSU30220" /db_xref="EnsemblGenomes-Tr:CAB15000" /db_xref="GOA:P53556" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004723" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11527" /db_xref="UniProtKB/Swiss-Prot:P53556" /translation="MKIDSWLNERLDRMKEAGVHRNLRSMDGAPVPERNIDGENQTVW SSNNYLGLASDRRLIDAAQTALQQFGTGSSGSRLTTGNSVWHEKLEKKIASFKLTEAA LLFSSGYLANVGVLSSLPEKEDVILSDQLNHASMIDGCRLSKADTVVYRHIDMNDLEN KLNETQRYQRRFIVTDGVFSMDGTIAPLDQIISLAKRYHAFVVVDDAHATGVLGDSGQ GTSEYFGVCPDIVIGTLSKAVGAEGGFAAGSAVFIDFLLNHARTFIFQTAIPPASCAA AHEAFNIIEASREKRQLLFSYISMIRTSLKNMGYVVKGDHTPIIPVVIGDAHKTVLFA EKLQGKGIYAPAIRPPTVAPGESRIRITITSDHSMGDIDHLLQTFHSIGKELHII*" /label="bioFC CDS" gene complement(2612762..2613931) /gene="bioFC" /locus_tag="BSU_30220" /old_locus_tag="BSU30220" /label="bioFC gene" promotor_-35 2612798..2612805 /Source="Nicolas_upshift_promotors" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2612820..2612839 /Source="Nicolas_upshift_promotors" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2612838 /Source="Nicolas_upshifts" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2613921..2615267) /gene="bioK" /locus_tag="BSU_30230" /old_locus_tag="BSU30230" /EC_number="2.6.1.105" /function="4.1: Biotin" /experiment="publication(s) with functional evidences, PMID:15880481, 20565114, 21437340" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15880481, 20565114, 21437340; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-lysine-8-amino-7-oxononanoate aminotransferase" /protein_id="NP_390901.1" /db_xref="EnsemblGenomes-Gn:BSU30230" /db_xref="EnsemblGenomes-Tr:CAB15001" /db_xref="GOA:P53555" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR005815" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="PDB:3DOD" /db_xref="PDB:3DRD" /db_xref="PDB:3DU4" /db_xref="SubtiList:BG11524" /db_xref="UniProtKB/Swiss-Prot:P53555" /translation="MTHDLIEKSKKHLWLPFTQMKDYDENPLIIESGTGIKVKDINGK EYYDGFSSVWLNVHGHRKKELDDAIKKQLGKIAHSTLLGMTNVPATQLAETLIDISPK KLTRVFYSDSGAEAMEIALKMAFQYWKNIGKPEKQKFIAMKNGYHGDTIGAVSVGSIE LFHHVYGPLMFESYKAPIPYVYRSESGDPDECRDQCLRELAQLLEEHHEEIAALSIES MVQGASGMIVMPEGYLAGVRELCTTYDVLMIVDEVATGFGRTGKMFACEHENVQPDLM AAGKGITGGYLPIAVTFATEDIYKAFYDDYENLKTFFHGHSYTGNQLGCAVALENLAL FESENIVEQVAEKSKKLHFLLQDLHALPHVGDIRQLGFMCGAELVRSKETKEPYPADR RIGYKVSLKMRELGMLTRPLGDVIAFLPPLASTAEELSEMVAIMKQAIHEVTSLED*" /label="bioK CDS" gene complement(2613921..2615267) /gene="bioK" /locus_tag="BSU_30230" /old_locus_tag="BSU30230" /label="bioK gene" promotor_-35 2614337..2614341 /Source="Nicolas_upshift_promotors" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2614356 /Source="Nicolas_upshifts" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2614357..2614375 /Source="Nicolas_upshift_promotors" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2615257..2616033) /gene="bioW" /locus_tag="BSU_30240" /old_locus_tag="BSU30240" /EC_number="6.2.1.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8763940, 11368323, 11717296, 21437340, 28196402, 29054876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763940, 11368323, 11717296, 21437340, 28196402, 29054876; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-carboxyhexanoate-CoA ligase (pimeloyl-CoA synthase)" /protein_id="NP_390902.3" /db_xref="EnsemblGenomes-Gn:BSU30240" /db_xref="EnsemblGenomes-Tr:CAB15002" /db_xref="GOA:P53559" /db_xref="InterPro:IPR005499" /db_xref="PDB:5FLG" /db_xref="PDB:5FLL" /db_xref="PDB:5FM0" /db_xref="PDB:5G1F" /db_xref="SubtiList:BG11529" /db_xref="UniProtKB/Swiss-Prot:P53559" /translation="MQEETFYSVRMRASMNGSHEDGGKHISGGERLIPFHEMKHTVNA LLEKGLSHSRGKPDFMQIQFEEVHESIKTIQPLPVHTNEVSCPEEGQKLARLLLEKEG VSRDVIEKAYEQIPEWSDVRGAVLFDIHTGKRMDQTKEKGVRVSRMDWPDANFEKWAL HSHVPAHSRIKEALALASKVSRHPAVVAELCWSDDPDYITGYVAGKKMGYQRITAMKE YGTEEGCRVFFIDGSNDVNTYIHDLEKQPILIEWEEDHDS*" /label="bioW CDS" gene complement(2615257..2616033) /gene="bioW" /locus_tag="BSU_30240" /old_locus_tag="BSU30240" /label="bioW gene" S_feature complement(2616034..2616126) /Source="Nicolas_S_feature" /locus_tag="new_3095456_3095548_c" /HighExp="T-5.40H, GM 60, LPh, GM 25, HPh, MG 120, M9-exp, BMM, GM 5, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1155" promotor_-10 complement(2616112..2616131) /Source="Nicolas_upshift_promotors" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2616126) /Source="Nicolas_upshifts" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2616146..2616153) /Source="Nicolas_upshift_promotors" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2616243..2617142) /gene="ytaP" /locus_tag="BSU_30250" /old_locus_tag="BSU30250" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390903.1" /db_xref="EnsemblGenomes-Gn:BSU30250" /db_xref="EnsemblGenomes-Tr:CAB15003" /db_xref="GOA:O34973" /db_xref="InterPro:IPR002471" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11786" /db_xref="UniProtKB/Swiss-Prot:O34973" /translation="MRAERRKQLFRLLGDLPDRRPISVETLRIEEREENIVETLLLDL NGHEKAPAYFVKPKKTEGPCPAVLFQHSHGGQYDRGKSELIEGADYLKTPSFSDELTS LGYGVLAIDHWGFGDRRGKAESEIFKEMLLTGKVMWGMMIYDSLSALDYMQSRSDVQP DRIGTIGMSMGGLMAWWTAALDDRIKVCVDLCSQVDHHVLIKTQNLDRHGFYYYVPSL AKHFSASEIQSLIAPRPHLSLVGVHDRLTPAEGVDKIEKELTAVYAGQGAADCYRVVR SASGHFETAVIRHEAVRFLQKWL*" /label="ytaP CDS" gene complement(2616243..2617142) /gene="ytaP" /locus_tag="BSU_30250" /old_locus_tag="BSU30250" /label="ytaP gene" promotor_-10 complement(2617165..2617183) /Source="Nicolas_upshift_promotors" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2617182) /Source="Nicolas_upshifts" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2617194..2617202) /Source="Nicolas_upshift_promotors" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2617272..2617279 /Source="Nicolas_upshift_promotors" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2617295..2617314 /Source="Nicolas_upshift_promotors" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2617301 /Source="Nicolas_upshifts" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="upshifts" CDS 2617360..2618394 /gene="msmR" /locus_tag="BSU_30260" /old_locus_tag="BSU30260" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12847288; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LacI family)" /protein_id="NP_390904.1" /db_xref="EnsemblGenomes-Gn:BSU30260" /db_xref="EnsemblGenomes-Tr:CAB15004" /db_xref="GOA:O34829" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12626" /db_xref="UniProtKB/Swiss-Prot:O34829" /translation="MVRIKDIALKAKVSSATVSRILNEDESLSVAGETRQRVINIAEE LGYQTVAKRRKSRGQKQRAQPLIGVLSCLSPDQERQDPYFSSIRKGIEKECFEQEIFI TNSIHLGSFQEHIFRELDGVIVIGRVHDEAVKHISGRLEHAVFINHSPDPQAYDSIGI DFESASRQAIDHLFDLGYKRLGYIGGQEKEHTLKDGQSIRRTIEDKRLTAFLESAAPQ PEHVLIGEYSMREGYRLMKKAIDQGHLPEAFFIASDSMAIGALKALQEAGLQVPRDTA IVSFNGIEEAEFASTPLTTVKVYTEEMGRTGVKLLLDRLNGRTLPQHVTLPTTLIVRQ SCGCTAKEVT*" /label="msmR CDS" gene 2617360..2618394 /gene="msmR" /locus_tag="BSU_30260" /old_locus_tag="BSU30260" /label="msmR gene" promotor_-35 2618343..2618350 /Source="Nicolas_upshift_promotors" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2618365..2618373 /Source="Nicolas_upshift_promotors" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2618382 /Source="Nicolas_upshifts" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="upshifts" CDS 2618428..2619708 /gene="msmE" /locus_tag="BSU_30270" /old_locus_tag="BSU30270" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8449892, 12847288, 16707683, 18954360, 28036052; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="multiple sugar-binding lipoprotein" /protein_id="NP_390905.1" /db_xref="EnsemblGenomes-Gn:BSU30270" /db_xref="EnsemblGenomes-Tr:CAB15005" /db_xref="GOA:O34335" /db_xref="InterPro:IPR006059" /db_xref="PDB:4R6H" /db_xref="SubtiList:BG12625" /db_xref="UniProtKB/Swiss-Prot:O34335" /translation="MKHTFVLFLSLILLVLPGCSAEKSSADTAKKTLTIYSTMSTDSE RDTFRKLAAAFEKEHSDIHVSLHFPGNDYENMMRVRMAANDLPDLFDTHGWGKIRYGE YTADLRDMKWTQDLDPNLNSILKNKSGKVYAYPINQAKDGLAYNRNILDRYGIAPPET MDDFIKALRTIKEKSKGSIVPFWFAGYDKSSFAQYYDQFATPLLITDPAHNEKKQLIN GTFQWSKFTYLSEILKQMQKEKLINIDAVTAKKSQLIELMAQNKIAFTMQGGTLGQDV AQINPNVKVGIIPTPAIHPGDDPIWIGGERYTLAAWKDSPQLKEAKDFIAFMARPANA KQMAEATSLPSGLTNVKADIFYANDYEYYQDVKVEPYFDRLYLPNGMWDVLGTVGQEL AADILAPQDISQKLGREYKRLREQSETQGAENNE*" /label="msmE CDS" gene 2618428..2619708 /gene="msmE" /locus_tag="BSU_30270" /old_locus_tag="BSU30270" /label="msmE gene" CDS 2619701..2620612 /gene="msmF" /locus_tag="BSU_30280" /old_locus_tag="BSU30280" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1537846, 12847288, 15849754, 16707683, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="carbohydrate ABC transporter (permease)" /protein_id="NP_390906.1" /db_xref="EnsemblGenomes-Gn:BSU30280" /db_xref="EnsemblGenomes-Tr:CAB15006" /db_xref="GOA:O34706" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12565" /db_xref="UniProtKB/Swiss-Prot:O34706" /translation="MSEIARDVHVKQVKPKKQSSLWWMYIPALLSVLVFMIYPFVKGT LITFTNWNGFSQVYQWVGFAQYERLFSDPDTWHILKNTLHYGLGSTFFQNVVGLLYAL LLNQSIKTKAVTRTIVYLPVMISPLIMGYIWYFFFSYDGGALNDLLGVFGISPINALA SPSLNPWIIVMINTYQYVGIAMVVYLAGLQSIPKDYYEAAQMDGAKQGQQFFTITLPL LMPSITINIVINIIGGLKLFDVIIALTAGGPGNASQSMSTFMYDLYFKRQDAGYAATQ GIFMAFVILIISFCALAYFKRKETEMS*" /label="msmF CDS" gene 2619701..2620612 /gene="msmF" /locus_tag="BSU_30280" /old_locus_tag="BSU30280" /label="msmF gene" CDS 2620609..2621439 /gene="msmG" /locus_tag="BSU_30290" /old_locus_tag="BSU30290" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1537846, 15849754, 16707683, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="maltose and multiple sugars ABC transporter (permease)" /protein_id="NP_390907.1" /db_xref="EnsemblGenomes-Gn:BSU30290" /db_xref="EnsemblGenomes-Tr:CAB15007" /db_xref="GOA:O34518" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12564" /db_xref="UniProtKB/Swiss-Prot:O34518" /translation="MRAARTKSMRIITLLAAIVACAHFIPFYILLTTSLKAKGDYSSK WIFPADISFHNFSEAWERASLGNSFINTMIITGFSALLLIIFGSLAAYPLARRETKLN KAVFALLISIMIIPPLTSMVPLYRMVVDAGMVNTHAIAIFINTAAYMPLTVFLYSGFI RSTIPKELVEAARIDGAGMLKIFFTIVFPLLKPITATICIISCVFIWNDYQFAIFFLQ DQKVQTLTVAMAGFFGENANNLHLVAAAALMAMLPMVVLFLALQKYFIAGLSSGAVKG *" /label="msmG CDS" gene 2620609..2621439 /gene="msmG" /locus_tag="BSU_30290" /old_locus_tag="BSU30290" /label="msmG gene" promotor_-35 2621412..2621416 /Source="Nicolas_upshift_promotors" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2621432..2621451 /Source="Nicolas_upshift_promotors" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2621440 /Source="Nicolas_upshifts" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2621459..2622757 /gene="melA" /locus_tag="BSU_30300" /old_locus_tag="BSU30300" /EC_number="3.2.1.22" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12847288; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-D-galactoside galactohydrolase" /protein_id="NP_390908.1" /db_xref="EnsemblGenomes-Gn:BSU30300" /db_xref="EnsemblGenomes-Tr:CAB15008" /db_xref="GOA:O34645" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12615" /db_xref="UniProtKB/Swiss-Prot:O34645" /translation="MKKITFIGAGSTIFAKNVLGDCLLTEALNGFEFALYDIDPKRLQ ESQLMLENLRDRYNPSVAINSYDDRKLALQNAGYVINAIQVGGYKPSTVIDFEIPKRY GLRQTIADTVGIGGIFRSLRTIPVLFDIAKDMEEMCPDAWFLNYTNPMATLTGAMLRY TNIKTIGLCHSVQVCTKDLFKALGMEHDGIEERIAGINHMAWLLEVKKDGTDLYPEIK RRAKEKQKTKHHDMVRFELMDKFGYYVTESSEHNAEYHPYFIKRNYPELISELQIPLD EYPRRCVKQIENWEKMRDDIVNNKNLTHERSKEYGSRIIEAMETNEPFTFGGNVLNTG LITNLPSKAVVEVTCVADRKKITPCFAGELPEQLAALNRTNINTQLMTIEAAVTRKKE AVYQAAMLDPHTSAELSMKDIISMCDDLFAAHGDWLPEYK*" /label="melA CDS" gene 2621459..2622757 /gene="melA" /locus_tag="BSU_30300" /old_locus_tag="BSU30300" /label="melA gene" downshifts 2622738 /Source="Nicolas_upshifts" /id="D1557" /incds=0 /nref=12 /ntot=55 /MaxReadThrough="3.99614" /MaxDrop="3.96455" /score="26.0469828" /energy="-11.9" /TU="NA" /idTUdmin="U2346" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2622779..2623090) /gene="ytwF" /locus_tag="BSU_30310" /old_locus_tag="BSU30310" /EC_number="2.8.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 22730127; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur transferase" /protein_id="NP_390909.2" /db_xref="EnsemblGenomes-Gn:BSU30310" /db_xref="EnsemblGenomes-Tr:CAB15009" /db_xref="GOA:O32072" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG13932" /db_xref="UniProtKB/Swiss-Prot:O32072" /translation="MEIKEISTAALKEKIEADEELYLIDVREDEEVAEGMIPQAVHIR MGDIPEKMETLDKDKEYVFICRSGMRSMNVCKYLDEQGFKTVNVEGGMMAWEGETKPK N*" /label="ytwF CDS" gene complement(2622779..2623090) /gene="ytwF" /locus_tag="BSU_30310" /old_locus_tag="BSU30310" /label="ytwF gene" downshifts complement(2622790) /Source="Nicolas_upshifts" /id="D1558" /incds=0 /nref=84 /ntot=254 /MaxReadThrough="2.71726" /MaxDrop="5.77228" /score="23.1306393" /energy="-11.9" /TU="NA" /idTUdmin="U2349" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2623114..2623133) /Source="Nicolas_upshift_promotors" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2623122) /Source="Nicolas_upshifts" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2623148..2623155) /Source="Nicolas_upshift_promotors" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2623156 /Source="Nicolas_upshifts" /id="D1559" /incds=0 /nref=3 /ntot=17 /MaxReadThrough="0.749090000000001" /MaxDrop="4.59307" /score="20.1681452" /energy="-11.2" /TU="NA" /idTUdmin="U2346" /TUdmin=418 /isTUend="FALSE" /label="downshifts" CDS complement(2623207..2625621) /gene="leuS" /locus_tag="BSU_30320" /old_locus_tag="BSU30320" /EC_number="6.1.1.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1317842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="leucyl-tRNA synthetase" /protein_id="NP_390910.1" /db_xref="EnsemblGenomes-Gn:BSU30320" /db_xref="EnsemblGenomes-Tr:CAB15010" /db_xref="GOA:P36430" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002302" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015413" /db_xref="InterPro:IPR025709" /db_xref="SubtiList:BG10676" /db_xref="UniProtKB/Swiss-Prot:P36430" /translation="MSFQHKEIEKKWQTYWLENKTFATLDNNEKQKFYALDMFPYPSG AGLHVGHPEGYTATDILSRMKRMQGYDVLHPMGWDAFGLPAEQYALDTGNDPAVFTKQ NIDNFRRQIQALGFSYDWDREINTTDPEYYKWTQWIFLKLYEKGLAYVDEVPVNWCPA LGTVLANEEVIDGKSERGGHPVERRPMKQWMLKITAYADRLLEDLEELDWPESIKDMQ RNWIGRSEGAHVHFAIDGHDDSFTVFTTRPDTLFGATYTVLAPEHALVENITTAEQKE AVEAYIKEIQSKSDLERTDLAKTKTGVFTGAYAINPVNGEKLPIWIADYVLASYGTGA VMAVPGHDERDFEFAKTFGLPVKEVVKGGNVEEAAYTGDGEHVNSDFLNGLHKQEAIE KVIAWLEETKNGEKKVTYRLRDWLFSRQRYWGEPIPVIHWEDGTSTAVPEEELPLILP KTDEIKPSGTGESPLANIKEWVEVTDPETGKKGRRETNTMPQWAGSCWYFLRYIDPHN PDQLASPEKLEKWLPVDMYIGGAEHAVLHLLYARFWHKFLYDIGVVPTKEPFQKLYNQ GMILGENNEKMSKSKGNVVNPDEIVASHGADTLRLYEMFMGPLDASIAWSESGLDGAR RFLDRVWRLFIEDSGELNGKIVEGAGETLERVYHETVMKVTDHYEGLRFNTGISQLMV FINEAYKATELPKEYMEGFVKLLSPVAPHLAEELWEKLGHSGTIAYEAWPVYDETKLV DDEVEIVVQLNGKVKAKLQVPADATKEQLEQLAQADEKVKEQLEGKTIRKIIAVPGKL VNIVAN*" /label="leuS CDS" gene complement(2623207..2625621) /gene="leuS" /locus_tag="BSU_30320" /old_locus_tag="BSU30320" /label="leuS gene" downshifts complement(2623211) /Source="Nicolas_upshifts" /id="D1560" /incds=0 /nref=115 /ntot=224 /MaxReadThrough="3.2803" /MaxDrop="4.46738" /score="33.3300042" /energy="-11.2" /TU="U2350" /idTUdmin="U2350" /TUdmin="-67" /isTUend="FALSE" /label="downshifts" S_feature complement(2625622..2625717) /Source="Nicolas_S_feature" /locus_tag="new_3105044_3105139_c" /HighExp="G150, G180, G135, LBGexp, HPh, LBGtran, Paraq, Lbexp, H2O2, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.989" /label="S1156" misc_RNA complement(2625731..2625945) /gene="tboL" /locus_tag="BSU_misc_RNA_49" /product="T-box riboswitch specific of leucine tRNA ligase" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201, 27169680; Product type n: RNA" /function="16.3: Control" /label="tboL RNA" gene complement(2625731..2625945) /gene="tboL" /locus_tag="BSU_misc_RNA_49" /label="tboL gene" downshifts complement(2625762) /Source="Nicolas_upshifts" /id="D1561" /incds=0 /nref=8 /ntot=38 /MaxReadThrough="6.86098" /MaxDrop="4.90189" /score="40.6873438" /energy="-16.7" /TU="U2350" /idTUdmin="U2352" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2625957..2625976) /Source="Nicolas_upshift_promotors" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2625978) /Source="Nicolas_upshifts" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2625982..2625987 /Source="Nicolas_upshift_promotors" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2625991..2625996) /Source="Nicolas_upshift_promotors" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2626003..2626021 /Source="Nicolas_upshift_promotors" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2626016..2626456 /Source="Nicolas_S_feature" /locus_tag="new_3105438_3105878" /HighExp="S4, S5, S3, S8, S7, S6, T5.0H, LoTm, C30, M9-stat" /AntisenseName="ytvB" /AntisenseCor="0.57398798861917499" /AntisenseRegPval="-24.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1157" upshifts 2626016 /Source="Nicolas_upshifts" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2626048..2626383) /gene="ytvB" /locus_tag="BSU_30330" /old_locus_tag="BSU30330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16923906; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative conserved membrane protein" /protein_id="NP_390911.3" /db_xref="EnsemblGenomes-Gn:BSU30330" /db_xref="EnsemblGenomes-Tr:CAB15011" /db_xref="GOA:O34881" /db_xref="InterPro:IPR025353" /db_xref="SubtiList:BG13929" /db_xref="UniProtKB/Swiss-Prot:O34881" /translation="MKMLHQVLIACVIGGIMGILGHVKKRGRLEKPRMTKRFIYLGFL EDWFIGMTASILLVLSADPDSGIQLVILSIISGYGGEAVLRSFDFVRELNSGGEPAES KRQTKTPPE*" /label="ytvB CDS" gene complement(2626048..2626383) /gene="ytvB" /locus_tag="BSU_30330" /old_locus_tag="BSU30330" /label="ytvB gene" S_feature complement(2626378..2626642) /Source="Nicolas_S_feature" /locus_tag="new_3105800_3106064_c" /HighExp="S6, S8, S7, Etha, S5, M9-stat, B60, BT, B36, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1158" promotor_-10 complement(2626627..2626646) /Source="Nicolas_upshift_promotors" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="promotor_-10" upshifts complement(2626642) /Source="Nicolas_upshifts" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="upshifts" promotor_-35 complement(2626661..2626668) /Source="Nicolas_upshift_promotors" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="promotor_-35" promotor_-35 2626681..2626688 /Source="Nicolas_upshift_promotors" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2626702..2626721 /Source="Nicolas_upshift_promotors" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2626718 /Source="Nicolas_upshifts" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="upshifts" S_feature 2626720..2626787 /Source="Nicolas_S_feature" /locus_tag="new_3106142_3106209" /HighExp="M40t90, Etha, dia5, HiOs, dia15, H2O2, BC, Diami, M0t90, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1159" CDS 2626788..2627573 /gene="blrA" /locus_tag="BSU_30340" /old_locus_tag="BSU30340" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11964249, 16923906, 16923909, 17200735, 17443319, 17575448, 19948797, 21259411, 21851109, 23416074, 24171435, 25211155, 27203230, 28502782, 28632317" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11964249, 16923906, 16923909, 17200735, 17443319, 17575448, 19948797, 21259411, 21851109, 23416074, 24171435, 25211155, 27203230, 28502782, 28632317; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="blue light GTP-binding receptor" /protein_id="NP_390912.1" /db_xref="EnsemblGenomes-Gn:BSU30340" /db_xref="EnsemblGenomes-Tr:CAB15012" /db_xref="GOA:O34627" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036513" /db_xref="PDB:1IUM" /db_xref="PDB:2MWG" /db_xref="PDB:2PR5" /db_xref="PDB:2PR6" /db_xref="PDB:4GCZ" /db_xref="SubtiList:BG13928" /db_xref="UniProtKB/Swiss-Prot:O34627" /translation="MASFQSFGIPGQLEVIKKALDHVRVGVVITDPALEDNPIVYVNQ GFVQMTGYETEEILGKNCRFLQGKHTDPAEVDNIRTALQNKEPVTVQIQNYKKDGTMF WNELNIDPMEIEDKTYFVGIQNDITKQKEYEKLLEDSLTEITALSTPIVPIRNGISAL PLVGNLTEERFNSIVCTLTNILSTSKDDYLIIDLSGLAQVNEQTADQIFKLSHLLKLT GTELIITGIKPELAMKMNKLDANFSSLKTYSNVKDAVKVLPIM*" /label="blrA CDS" gene 2626788..2627573 /gene="blrA" /locus_tag="BSU_30340" /old_locus_tag="BSU30340" /label="blrA gene" S_feature 2627574..2627630 /Source="Nicolas_S_feature" /locus_tag="new_3106996_3107052" /HighExp="Sw, M40t90, BC, Etha, dia5, dia15, H2O2, Mt0, M0t90, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1160" CDS complement(2627810..2629003) /gene="yttB" /locus_tag="BSU_30350" /old_locus_tag="BSU30350" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534, 15849754, 16850406, 28472044; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390913.1" /db_xref="EnsemblGenomes-Gn:BSU30350" /db_xref="EnsemblGenomes-Tr:CAB15013" /db_xref="GOA:O34546" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13925" /db_xref="UniProtKB/Swiss-Prot:O34546" /translation="MPRALKILVIGMFINVTGASFLWPLNTIYIHNHLGKSLTVAGLV LMLNSGASVAGNLCGGFLFDKIGGFKSIMLGIAITLASLMGLVFFHDWPAYIVLLTIV GFGSGVVFPASYAMAGSVWPEGGRKAFNAIYVAQNAGVAVGSALGGVVASFSFSYVFL ANAVLYLIFFFIVYFGFRNIQTGDASQTSVLDYDAVNSKAKFAALIILSGGYVLGWLA YSQWSTTIASYTQSIGISLSLYSVLWTVNGILIVLGQPLVSFVVKKWAESLKAQMVIG FIIFIVSFSMLLTAKQFPMFLAAMVILTIGEMLVWPAVPTIANQLAPKGKEGFYQGFV NSAATGGRMIGPLFGGVLVDHYGIRALVLSLLVLLLISIATTLLYDKRIKSAKETNKQ ASISS*" /label="yttB CDS" gene complement(2627810..2629003) /gene="yttB" /locus_tag="BSU_30350" /old_locus_tag="BSU30350" /label="yttB gene" downshifts complement(2627830) /Source="Nicolas_upshifts" /id="D1562" /incds=0 /nref=5 /ntot=47 /MaxReadThrough="2.03991" /MaxDrop="3.41948" /score="-7.70376219" /energy="-9.4" /TU="NA" /idTUdmin="U2354" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2629004..2629102) /Source="Nicolas_S_feature" /locus_tag="new_3108426_3108524_c" /HighExp="dia15, LBGstat, H2O2, G180, LPhT, Paraq, Oxctl, G150, G135, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1161" promotor_-10 complement(2629083..2629102) /Source="Nicolas_upshift_promotors" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2629102) /Source="Nicolas_upshifts" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2629116..2629123) /Source="Nicolas_upshift_promotors" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2629140..2629143 /Source="Nicolas_upshift_promotors" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2629158..2629177 /Source="Nicolas_upshift_promotors" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2629162 /Source="Nicolas_upshifts" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="upshifts" CDS 2629192..2629938 /gene="yttA" /locus_tag="BSU_30360" /old_locus_tag="BSU30360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12823818" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390914.2" /db_xref="EnsemblGenomes-Gn:BSU30360" /db_xref="EnsemblGenomes-Tr:CAB15014" /db_xref="GOA:Q795Q5" /db_xref="InterPro:IPR006876" /db_xref="InterPro:IPR035451" /db_xref="SubtiList:BG13924" /db_xref="UniProtKB/Swiss-Prot:Q795Q5" /translation="MEMVLAFLGFLACLIALGYGLYHLVRYVLKKEKRFSKRLFWPLF IGGLVLLFTGAALAEPDTAAANAEKKYSALNAEYKNLTKEHEELEKEYKSVSSEAKKL KDNKEDQDKLEKLKNENSDLKKTQKSLKAEIKELQENQKQLKEDAKTAKAENETLRQD KTKLENQLKETESQTASSHEDTGSSSNNTSKSDETKTADKAEGCNIKGSRNGIYHTPG STYYDRTTDPAEMFCSVEEAEAAGYRAPKR*" /label="yttA CDS" gene 2629192..2629938 /gene="yttA" /locus_tag="BSU_30360" /old_locus_tag="BSU30360" /label="yttA gene" downshifts 2629833 /Source="Nicolas_upshifts" /id="D1563" /incds=1 /nref=2 /ntot=94 /MaxReadThrough="4.11368" /MaxDrop="3.01036" /score="23.2955589" /energy="-11.6" /TU="U2355" /idTUdmin="U2355" /TUdmin="-99" /isTUend="FALSE" /label="downshifts" downshifts 2629932 /Source="Nicolas_upshifts" /id="D1564" /incds=0 /nref=31 /ntot=169 /MaxReadThrough="1.73994" /MaxDrop="4.19129" /score="23.2955589" /energy="-11.6" /TU="NA" /idTUdmin="U2355" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2629975..2631915) /gene="bceB" /locus_tag="BSU_30370" /old_locus_tag="BSU30370" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14612242, 15849754, 16850406, 17905982, 25118291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612242, 15849754, 16850406, 17905982, 25118291; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease)" /protein_id="NP_390915.1" /db_xref="EnsemblGenomes-Gn:BSU30370" /db_xref="EnsemblGenomes-Tr:CAB15015" /db_xref="GOA:O34741" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR027022" /db_xref="SubtiList:BG13921" /db_xref="UniProtKB/Swiss-Prot:O34741" /translation="MNINQLILRNLKKNLRNYYLYVFALIFSVALYFAFVTLQYDPAI NEVKASIKGAAAIKTASILLVAVVAIFILYANTIFIKRRSKEIGLFQLIGMTKHKIFR ILSAENVMLYFGSLAIGVAAGFSISKLVLMILFKIVDVKADAKLHFSEQALVQTVIVF CGIYLLIMIMNYTFIKKQSILSLFKVTSSTEDKVKKISFFQMLIGALGIVLILTGYYV SSELFGGKFKTINELFVAMSFILGSVIIGTFLFYKGSVTFISNIIRKSKGGYLNISEV LSLSSIMFRMKSNALLLTIITTVSALAIGLLSLAYISYYSSEKTAEQNVAADFSFMNE KDAKLFENKLRESNISFVKKATPVLQANVDIANIMDGTPKEMQGDPGNMQLAVVSDKD VKGVDVAAGEAVFSGYTDLLQKIMVFKDSGVIKVKSKHETQPLKYKGLREEFLVSYTF TSGGMPAVIVDDSLFKQLDKDKDPRIQLAQSTFIGVNVKHDDQMEKANELFQQVNKKN EHLSRLDTSAAQKSLFGMVMFIVGFLGLTFLITSGCILYFKQMGESEDEKPSYTILRK LGFTQGDLIKGIRIKQMYNFGIPLVVGLFHSYFAVQSGWFLFGSEVWAPMIMVMVLYT ALYSIFGFLSVLYYKKVIKSSL*" /label="bceB CDS" gene complement(2629975..2631915) /gene="bceB" /locus_tag="BSU_30370" /old_locus_tag="BSU30370" /label="bceB gene" downshifts complement(2629986) /Source="Nicolas_upshifts" /id="D1565" /incds=0 /nref=13 /ntot=89 /MaxReadThrough="1.56566" /MaxDrop="4.45006" /score="29.4802229" /energy="-11.6" /TU="NA" /idTUdmin="U2356" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2631905..2632666) /gene="bceA" /locus_tag="BSU_30380" /old_locus_tag="BSU30380" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14612242, 17905982, 25118291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612242, 17905982, 25118291; Product type t: transporter" /codon_start=1 /transl_table=11 /product="bacitracin ABC efflux transporter (ATP-binding protein)" /protein_id="NP_390916.1" /db_xref="EnsemblGenomes-Gn:BSU30380" /db_xref="EnsemblGenomes-Tr:CAB15016" /db_xref="GOA:O34697" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13920" /db_xref="UniProtKB/Swiss-Prot:O34697" /translation="MVILEANKIRKSYGNKLNKQEVLKGIDIHIEKGEFVSIMGASGS GKTTLLNVLSSIDQVSHGTIHINGNDMTAMKEKQLAEFRKQHLGFIFQDYNLLDTLTV KENILLPLSITKLSKKEANRKFEEVAKELGIYELRDKYPNEISGGQKQRTSAGRAFIH DPSIIFADEPTGALDSKSASDLLNKLSQLNQKRNATIIMVTHDPVAASYCGRVIFIKD GQMYTQLNKGGQDRQTFFQDIMKTQGVLGGVQHEH*" /label="bceA CDS" gene complement(2631905..2632666) /gene="bceA" /locus_tag="BSU_30380" /old_locus_tag="BSU30380" /label="bceA gene" misc_feature complement(2632690..2632708) /Source="Nicolas_upshift_promotors" /id="U2356" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.383616383616384" /psig="0.83016983016983" /xcortree=3191 /SigmaFactorBS="gacgaaaatgtcacatgcttttcttttttgttcgccgtatcg aaggaaaagcccggcattcCTTTTTATAATGAGATTATccaatataaaggagactgcg t" /listShort="bceA, bceB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2632709) /Source="Nicolas_upshifts" /id="U2356" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.383616383616384" /psig="0.83016983016983" /xcortree=3191 /SigmaFactorBS="gacgaaaatgtcacatgcttttcttttttgttcgccgtatcg aaggaaaagcccggcattcCTTTTTATAATGAGATTATccaatataaaggagactgcg t" /listShort="bceA, bceB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2632768..2633772) /gene="bceS" /locus_tag="BSU_30390" /old_locus_tag="BSU30390" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17905982, 25118291, 25685323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17905982, 25118291, 25685323; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase controlling resistance to antibiotics affecting the envelope [YtsA]" /protein_id="NP_390917.1" /db_xref="EnsemblGenomes-Gn:BSU30390" /db_xref="EnsemblGenomes-Tr:CAB15017" /db_xref="GOA:O35044" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13919" /db_xref="UniProtKB/Swiss-Prot:O35044" /translation="MIKAFLIERRSWIAAFLFQQALMLFIAFVDPSISFGNVLYMVYL CILFFIIFLWFRYRKETAFYKSLKTWENNLDVTAINEPETPFEAMVERSIAGQTEHLK QTAARHRLALENEKDELMAWIHEVKTPLTAMHLIIDRMEEKALKSQLSYEWLRIHLLL DQQLHQKRISFIENDLSVEFIQLQPLIFKEIKDLQSWCIQKGIGFDIQLEAKEVLSDA KWLAFIIRQLLTNAVKYSEASEIEIKSFQKGEQTQLQVKDCGRGIDPKDVPRIFDKGF TSTTDHHDQASTGMGLYLAKKAAAPLLIHIDVESEFGAGTVFTLTFPIRNQFEHVISV *" /label="bceS CDS" gene complement(2632768..2633772) /gene="bceS" /locus_tag="BSU_30390" /old_locus_tag="BSU30390" /label="bceS gene" downshifts complement(2632807) /Source="Nicolas_upshifts" /id="D1566" /incds=0 /nref=25 /ntot=187 /MaxReadThrough="2.40611" /MaxDrop="4.6482" /score="29.3236847" /energy="-13.9" /TU="NA" /idTUdmin="U2357" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" CDS complement(2633765..2634460) /gene="bceR" /locus_tag="BSU_30400" /old_locus_tag="BSU30400" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17905982, 25118291, 25685323, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17905982, 25118291, 25685323, 27997719; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator controlling resistance to antibiotics affecting the envelope [YtsB]" /protein_id="NP_390918.1" /db_xref="EnsemblGenomes-Gn:BSU30400" /db_xref="EnsemblGenomes-Tr:CAB15018" /db_xref="GOA:O34951" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12340" /db_xref="UniProtKB/Swiss-Prot:O34951" /translation="MFKLLLIEDDESLFHEIKDRLTGWSYDVYGIQDFSQVLQEFAAV NPDCVIIDVQLPKFDGFHWCRLIRSRSNVPILFLSSRDHPADMVMSMQLGADDFIQKP FHFDVLIAKIQAMFRRVHHYNTEPSTIKTWCGAAVDAEQNLVSNDKGSVELTKNEMFI LKQLIEQKNKIVSREELIRSLWNDERFVSDNTLTVNVNRLRKKLDALQLGAYIETKVG QGYIAKEEDKFYD*" /label="bceR CDS" gene complement(2633765..2634460) /gene="bceR" /locus_tag="BSU_30400" /old_locus_tag="BSU30400" /label="bceR gene" promotor_-10 complement(2634484..2634502) /Source="Nicolas_upshift_promotors" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2634496) /Source="Nicolas_upshifts" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2634518..2634521) /Source="Nicolas_upshift_promotors" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2634557..2635867) /gene="ytrF" /locus_tag="BSU_30410" /old_locus_tag="BSU30410" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="metabolite permease involved in resistance to cell wall inhibitors" /protein_id="NP_390919.1" /db_xref="EnsemblGenomes-Gn:BSU30410" /db_xref="EnsemblGenomes-Tr:CAB15019" /db_xref="GOA:O35005" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG13916" /db_xref="UniProtKB/Swiss-Prot:O35005" /translation="MRFKDQVHFIRRNMKKNRLRVFMTILATTMACAFLVVLSSVGFG IQKTITDMTMSQQIVTKVSVMGKEGDKPIKKADLEKYDHVRSVVERTQVYEPNKATLG NRTNESSNLIFTNMNDELKANMELEKGRVAKSENEIVVGYDFAKRLLTKKESEEYNKK IEEAKGNPEDIKEPKGYTKDILNKTIELSVSKTDSKTGDVTKTKTYDFKIVGITKKPS QDWMEDSNIFISDQFKKDFSEFLDFKGGNVETNIGVFADKFENVEQLTNDLTDDGYYV TSVTTELEGANTFFMVFKIGLIFVGCIAVIISAIGIFNTMTMAVTERTQEIGIMKAIG ASPSIIRRMFLMESAYIGILGCVIGIIISYGVSYLVNLAVPMILAATSGGDAGDLNYT FSYIPASLVIIAVVICGGVAVISGMNPARKATKTNVLTALRREL*" /label="ytrF CDS" gene complement(2634557..2635867) /gene="ytrF" /locus_tag="BSU_30410" /old_locus_tag="BSU30410" /label="ytrF gene" downshifts complement(2634579) /Source="Nicolas_upshifts" /id="D1567" /incds=0 /nref=9 /ntot=170 /MaxReadThrough="4.26891" /MaxDrop="3.83905" /score="28.2472037" /energy="-13.6" /TU="U2359" /idTUdmin="U2359" /TUdmin="-1755" /isTUend="FALSE" /label="downshifts" CDS complement(2635857..2636552) /gene="ytrE" /locus_tag="BSU_30420" /old_locus_tag="BSU30420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 22720735, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 22720735, 22926563; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) involved in resistance to cell wall inhibitors" /protein_id="NP_390920.1" /db_xref="EnsemblGenomes-Gn:BSU30420" /db_xref="EnsemblGenomes-Tr:CAB15020" /db_xref="GOA:O34392" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13915" /db_xref="UniProtKB/Swiss-Prot:O34392" /translation="MIDVQHIDHSFTIGKKGRENEVPVLKDVSLSVAKGEIACIVGRS GSGKSTLLNLISGYISPTKGRIVINGTDVTGFNEKEWAQFRLDHFGFIFQSFQLIPGL TTYENVEMPLALKGIKPSERKQKVQDMLKRVGLENHAAHYPNELSGGQQQRVSIARAL ILNPSIILADEPTGSLDSETEHEVLELIQQLNRERGITFVIITHDDEVASIGHSKFQL HDGVLKGGITVEV*" /label="ytrE CDS" gene complement(2635857..2636552) /gene="ytrE" /locus_tag="BSU_30420" /old_locus_tag="BSU30420" /label="ytrE gene" CDS complement(2636567..2637544) /gene="ytrD" /locus_tag="BSU_30430" /old_locus_tag="BSU30430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter, permease component involved in resistance to cell wall inhibitors" /protein_id="NP_390921.1" /db_xref="EnsemblGenomes-Gn:BSU30430" /db_xref="EnsemblGenomes-Tr:CAB15021" /db_xref="GOA:O34953" /db_xref="InterPro:IPR023264" /db_xref="SubtiList:BG13914" /db_xref="UniProtKB/Swiss-Prot:O34953" /translation="MPDSGLLYKEWRQNKVALVITILVFILGNPLSILNMYLIYQGCV TGKENWVGPCVFSVDYLNSSFISLFWIWGVVLAVSQLGIERSKSFFDFTLSLPYTRGQ IFHAKFLTGGMVIVVPQLIGYVLSVLLIMLLKPDQAVYFHNYSLGMIIVSMLAYSLVM AGGALTGNSFAQLLVSFTVAISPFLLISLPVINLEILFGGSIDFIHGPVPKWVQYFIP IIYVDSKWAENSPYYLVIPAIMTIIFYIIGYISFVKMSNERNGYFFLWKPLNRPVQII VIIIGIMGFGYFGFTASESFAGYLIGMGTGAVIGFLISYFAIYKKMKLL*" /label="ytrD CDS" gene complement(2636567..2637544) /gene="ytrD" /locus_tag="BSU_30430" /old_locus_tag="BSU30430" /label="ytrD gene" CDS complement(2637574..2638560) /gene="ytrC" /locus_tag="BSU_30440" /old_locus_tag="BSU30440" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter, permease component involved in resistance to cell wall inhibitors" /protein_id="NP_390922.1" /db_xref="EnsemblGenomes-Gn:BSU30440" /db_xref="EnsemblGenomes-Tr:CAB15022" /db_xref="GOA:O34898" /db_xref="InterPro:IPR023264" /db_xref="SubtiList:BG13913" /db_xref="UniProtKB/Swiss-Prot:O34898" /translation="MVDRGLLYREWKQNQVVILLSIAFLVLANPLSIVNTYLSYQGCL DRQDPQYCDFIVNYSISNLIDINWVPGVILAVCFLGMERSKGTMDFILSLPYNRSQIF QTKFWLGGFVIVLSQLIGFLLAWLLILVYNPEHVYFFEHSSIGVIVISFMAFSLVMAA GALTGNAFAQLLTAFSAAILPYLIIALPVGNLEVVFGANIWEIFPSPESYFSLASNLS NLVPISYVVNEWLINSKYLLLIPAVMSMLFYLIGFISFKKLPSERNGHFFLWNRLDRP VQILVMAFGILGFGLFGYYTGHSIIGYILGMIIGAVAGFFVSYFSIYKKTKV*" /label="ytrC CDS" gene complement(2637574..2638560) /gene="ytrC" /locus_tag="BSU_30440" /old_locus_tag="BSU30440" /label="ytrC gene" promotor_-35 2638430..2638439 /Source="Nicolas_upshift_promotors" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2638446 /Source="Nicolas_upshifts" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2638452..2638467 /Source="Nicolas_upshift_promotors" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2638554..2639432) /gene="ytrB" /locus_tag="BSU_30450" /old_locus_tag="BSU30450" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 22926563; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) involved in resistance to cell wall inhibitors" /protein_id="NP_390923.1" /db_xref="EnsemblGenomes-Gn:BSU30450" /db_xref="EnsemblGenomes-Tr:CAB15023" /db_xref="GOA:O34641" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13912" /db_xref="UniProtKB/Swiss-Prot:O34641" /translation="MIELRQLSKAIDGNQVLKDVSLTIEKGEIFGLLGRNGSGKTTML RLIQQIIFADSGTILFDGVEIKKHPKVKQNIIYMPVQNPFYDKYTYKQLVDILRRIYP KFDVTYANELMNRYEIPETKKYRELSTGLKKQLSLVLSFAARPALILLDEPTDGIDAV TRHDVLQLMVDEVAERDTSILITSHRLEDIERMCNRIGFLEDNSLTNVMDLDELKEEY IKIQMAFDTDVNLAIREQNIPMLDQAGVFYTVLIPKSDEEKKSFLRELKPKVWNELPV NLEEVFIAKFGGKRRW*" /label="ytrB CDS" gene complement(2638554..2639432) /gene="ytrB" /locus_tag="BSU_30450" /old_locus_tag="BSU30450" /label="ytrB gene" CDS complement(2639425..2639817) /gene="ytrA" /locus_tag="BSU_30460" /old_locus_tag="BSU30460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10986249, 11756427, 17194626, 21856850, 28357385" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 11756427, 17194626, 21856850, 28357385; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family, cell wall antibiotics)" /protein_id="NP_390924.1" /db_xref="EnsemblGenomes-Gn:BSU30460" /db_xref="EnsemblGenomes-Tr:CAB15024" /db_xref="GOA:O34712" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13911" /db_xref="UniProtKB/Swiss-Prot:O34712" /translation="MIQIDPRSSTPIYEQIIQQMKELCLKGIMKPGDKLPSVRELATI IIANPNTVSKAYKELEREGIIETLRGRGTYISENAKTTLVEGKMTMIKEQLKQLIIDA HYAGVELEKLHEWIKEISADVKGGKKND*" /label="ytrA CDS" gene complement(2639425..2639817) /gene="ytrA" /locus_tag="BSU_30460" /old_locus_tag="BSU30460" /label="ytrA gene" S_feature complement(2639818..2640062) /Source="Nicolas_S_feature" /locus_tag="new_3119240_3119484_c" /HighExp="Cold, Salt, SMMPr, MG 15, M9-tran, G180, M9-exp, M/G, MG 25, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.71885600000000005" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1162" CDS complement(2639851..2639988) /locus_tag="BSU_30466" /old_locus_tag="BSU30466" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28357385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513999.1" /db_xref="EnsemblGenomes-Gn:BSU30466" /db_xref="EnsemblGenomes-Tr:CCQ48604" /db_xref="GOA:L8ECR1" /db_xref="UniProtKB/TrEMBL:L8ECR1" /translation="MKHKKRNKRNVPMLIAASVIACSFFLVLVMIGFEWQKSIIDHFY L*" /label="conserved protein of unknown function CDS" gene complement(2639851..2639988) /locus_tag="BSU_30466" /old_locus_tag="BSU30466" /label="gene" downshifts 2639986 /Source="Nicolas_upshifts" /id="D1568" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="2.62989" /MaxDrop="3.1332" /score="6.69010243" /energy="-14.4" /TU="NA" /idTUdmin="U2361" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2640057..2640076) /Source="Nicolas_upshift_promotors" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2640062) /Source="Nicolas_upshifts" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2640090..2640097) /Source="Nicolas_upshift_promotors" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2640143..2640415) /gene="ytzC" /locus_tag="BSU_30470" /old_locus_tag="BSU30470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390925.1" /db_xref="EnsemblGenomes-Gn:BSU30470" /db_xref="EnsemblGenomes-Tr:CAB15025" /db_xref="InterPro:IPR019668" /db_xref="SubtiList:BG13937" /db_xref="UniProtKB/Swiss-Prot:O32073" /translation="MATRQSVDEHLQQCMQAYDYAEEQLKIASKQEHYNDQEYSDAQM QLEDAVNALNKLWLSSNDQQREQLYRMRLQLQSLQNNMILQHPLDV*" /label="ytzC CDS" gene complement(2640143..2640415) /gene="ytzC" /locus_tag="BSU_30470" /old_locus_tag="BSU30470" /label="ytzC gene" downshifts complement(2640150) /Source="Nicolas_upshifts" /id="D1569" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="2.96566" /MaxDrop="8.4811" /score="36.3100501" /energy="-14.4" /TU="NA" /idTUdmin="U2360" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2640455..2640466) /Source="Nicolas_upshift_promotors" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2640459..2640467 /Source="Nicolas_upshift_promotors" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2640459) /Source="Nicolas_upshifts" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="upshifts" upshifts 2640470 /Source="Nicolas_upshifts" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2640481..2640487) /Source="Nicolas_upshift_promotors" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2640481..2640499 /Source="Nicolas_upshift_promotors" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2640510..2640515 /Source="Nicolas_upshift_promotors" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2640529..2640548 /Source="Nicolas_upshift_promotors" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2640536 /Source="Nicolas_upshifts" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="upshifts" CDS 2640577..2641545 /gene="ytqA" /locus_tag="BSU_30480" /old_locus_tag="BSU30480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10413665; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_390926.1" /db_xref="EnsemblGenomes-Gn:BSU30480" /db_xref="EnsemblGenomes-Tr:CAB15026" /db_xref="GOA:O35008" /db_xref="InterPro:IPR005911" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR032432" /db_xref="SubtiList:BG13908" /db_xref="UniProtKB/Swiss-Prot:O35008" /translation="MMQNNPFPYSNTEKRYHTLNYHLREHFGHKVFKVALDGGFDCPN RDGTVAHGGCTFCSAAGSGDFAGNRTDDLITQFHDIKNRMHEKWKDGKYIAYFQAFTN THAPVEVLREKFESVLALDDVVGISIATRPDCLPDDVVDYLAELNERTYLWVELGLQT VHERTALLINRAHDFNCYVEGVNKLRKHGIRVCSHIINGLPLEDRDMMMETAKAVADL DVQGIKIHLLHLLKGTPMVKQYEKGKLEFLSQDDYVQLVCDQLEIIPPEMIVHRITGD GPIELMIGPMWSVNKWEVLGAINKELENRGSYQGKFFQRLEEESAL*" /label="ytqA CDS" gene 2640577..2641545 /gene="ytqA" /locus_tag="BSU_30480" /old_locus_tag="BSU30480" /label="ytqA gene" CDS 2641542..2642126 /gene="ytqB" /locus_tag="BSU_30490" /old_locus_tag="BSU30490" /EC_number="2.1.1.-" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 22333191, 24699744; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA methylase" /protein_id="NP_390927.1" /db_xref="EnsemblGenomes-Gn:BSU30490" /db_xref="EnsemblGenomes-Tr:CAB15027" /db_xref="GOA:O34614" /db_xref="InterPro:IPR010719" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13909" /db_xref="UniProtKB/Swiss-Prot:O34614" /translation="MILKKILPYSKELLKMAAGEGDIVVDATMGNGHDTQFLAELVGE NGHVYAFDIQESAVANTKERLGDMYQARTTLFHKSHDKIAESLPPETHGKVAAAVFNL GYLPGGDKSITTNGSSTIKAIEQLLSIMKDEGLIVLVVYHGHPEGKAEKNDVLEFCRD LDQQTARVLTYGFINQQNDPPFIVAIEKKAQISK*" /label="ytqB CDS" gene 2641542..2642126 /gene="ytqB" /locus_tag="BSU_30490" /old_locus_tag="BSU30490" /label="ytqB gene" downshifts 2642090 /Source="Nicolas_upshifts" /id="D1570" /incds=0 /nref=58 /ntot=249 /MaxReadThrough="2.35311" /MaxDrop="4.47418" /score="22.0352465" /energy="-11.9" /TU="NA" /idTUdmin="U2362" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(2642116..>2642247) /gene="tbcS" /locus_tag="IIG_Bs13_pseudo_BSU_30500" /old_locus_tag="BSU_30500" /EC_number="4.2.3.130" /experiment="publication(s) with functional evidences, PMID:21627333, 24806199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21627333, 24806199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tetraprenyl-beta-curcumene synthase" /protein_id="NP_390928.1" /db_xref="EnsemblGenomes-Gn:BSU30500" /db_xref="EnsemblGenomes-Tr:CAB15028" /db_xref="GOA:O34707" /db_xref="InterPro:IPR019712" /db_xref="SubtiList:BG13901" /db_xref="UniProtKB/Swiss-Prot:O34707" /modified_by="User" /translation="LAKKLIKASGKTSLFFYINGRAYRKFQKMSWMKNSKKKAQIIC* " /label="IIG_Bs13_pseudo_BSU_30500" gene complement(2642116..>2642247) /gene="tbcS" /locus_tag="IIG_Bs13_pseudo_BSU_30500" /old_locus_tag="BSU_30500" /modified_by="User" /label="IIG_Bs13_pseudo_BSU_30500" downshifts complement(2642157) /Source="Nicolas_upshifts" /id="D1571" /incds=0 /nref=35 /ntot=240 /MaxReadThrough="3.47268" /MaxDrop="4.45295" /score="16.7564664" /energy="-10.1" /TU="U2364" /idTUdmin="U2365" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" SCAR 2642250..2642251 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs13" S_feature complement(<2642251..2642266) /Source="Nicolas_S_feature" /locus_tag="new_3123442_3124021_c" /HighExp="dia15, H2O2, Diami, Salt, dia5, M0t90, Lbstat, Etha, Paraq, Lbtran" /AntisenseName="ytoA" /AntisenseCor="-0.44861767737485803" /AntisenseRegPval="-14" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1163" promotor_-10 complement(2642257..2642276) /Source="Nicolas_upshift_promotors" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2642266) /Source="Nicolas_upshifts" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2642268..2642402) /Source="Nicolas_S_feature" /locus_tag="new_3124023_3124157_c" /HighExp="LoTm, Cold, dia5, dia15, Diami, H2O2, S7, G135, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1164" promotor_-35 complement(2642288..2642295) /Source="Nicolas_upshift_promotors" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2642377..2642396) /Source="Nicolas_upshift_promotors" /id="U2365" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.968031968031968" /psig="0.998001998001998" /xcortree=1850 /SigmaFactorBS="gtgctcatagaaaatagagaacaggaaagaataggtatgtgt ttttgcagaggctgtttatagtttTGTGATAAGATAAAAGTCATacgtttcatgctat a" /listShort="S1164, S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2642402) /Source="Nicolas_upshifts" /id="U2365" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.968031968031968" /psig="0.998001998001998" /xcortree=1850 /SigmaFactorBS="gtgctcatagaaaatagagaacaggaaagaataggtatgtgt ttttgcagaggctgtttatagtttTGTGATAAGATAAAAGTCATacgtttcatgctat a" /listShort="S1164, S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2642495..2643886) /gene="ytnA" /locus_tag="BSU_30530" /old_locus_tag="BSU30530" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_390931.1" /db_xref="EnsemblGenomes-Gn:BSU30530" /db_xref="EnsemblGenomes-Tr:CAB15031" /db_xref="GOA:O34618" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG13891" /db_xref="UniProtKB/Swiss-Prot:O34618" /translation="MQKQKQELHRGLEERHISLMSLGAAIGVGLFLGSASAIQLAGPG ILVAYAASGLVMFFIMRALGEMAIQKPVAGSFSRYARDYLGPLAGYLTGWNYWFLWVV TCMAEITAVGIYMGFWFPDVPNWIWALSALVIMTGVNFLAVKAYGELEFWFALIKIVA ILSMIAVGLLMIIAGVGNGGIATGISNLWNNGGFFPHGLKGVLLSLQMVMFAYLGIEM IGVTAGEVKNPQKSLAKAIDTVFWRILIFYVGALFVIMSIYPWQEIGSQGSPFVLTFQ KVGIPSAAGIINFVVLTAALSSCNSGIFSTGRMLFNLAEQKEAPQAYGQLTKGGIPGK AVLASAGALLVGVLLNYVVPAKVFTWVTSIATFGAIWTWAIILLSQIKYRKSLKPEEK KQLKYKMPLFPFTSYVSLAFLAFVVILMAYSPDTRVAVIIGPIWFLILLAVYYGKGFH KKNAAAASERNIS*" /label="ytnA CDS" gene complement(2642495..2643886) /gene="ytnA" /locus_tag="BSU_30530" /old_locus_tag="BSU30530" /label="ytnA gene" downshifts complement(2642503) /Source="Nicolas_upshifts" /id="D1572" /incds=0 /nref=133 /ntot=225 /MaxReadThrough="3.05784" /MaxDrop="5.43778" /score="3.82664462" /energy="-7.5" /TU="U2368" /idTUdmin="U2368" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" S_feature complement(2643887..2644021) /Source="Nicolas_S_feature" /locus_tag="new_3125642_3125776_c" /HighExp="Oxctl, Paraq, Heat, Lbexp, G150, S0, dia0, H2O2, G180, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1165" CDS complement(2644022..2645920) /gene="asnB" /locus_tag="BSU_30540" /old_locus_tag="BSU30540" /EC_number="2.4.-.-" /EC_number="6.3.5.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 21949063, 28317238" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 21949063, 28317238; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="meso-diaminopimelic acid amidotransferase (asparagine synthetase)" /protein_id="NP_390932.1" /db_xref="EnsemblGenomes-Gn:BSU30540" /db_xref="EnsemblGenomes-Tr:CAB15032" /db_xref="GOA:P54420" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG11831" /db_xref="UniProtKB/Swiss-Prot:P54420" /translation="MCGFVGVFNKHPLAQTADQEELIKQMNQMIVHRGPDSDGYFHDE HVGFGFRRLSIIDVENGGQPLSYEDETYWIIFNGEIYNYIELREELEAKGYTFNTDSD TEVLLATYRHYKEEAASKLRGMFAFLIWNKNDHVLYGARDPFGIKPLYYTTINDQVYF ASERKSLMVAQNDIEIDKEALQQYMSFQFVPEPSTLDAHVKKVEPGSQFTIRPDGDIT FKTYFKANFKPVQTEEDKLVKEVRDAIYDSVNVHMRSDVPVGSFLSGGIDSSFIVSVA KEFHPSLKTFSVGFEQQGFSEVDVAKETAAALGIENISKVISPEEYMNELPKIVWHFD DPLADPAAIPLYFVAKEAKKHVTVALSGEGADELFGGYNIYREPLSLKPFERIPSGLK KMLLHVAAVMPEGMRGKSLLERGCTPLQDRYIGNAKIFEESVKKQLLKHYNPNLSYRD VTKTYFTESSSYSDINKMQYVDIHTWMRGDILLKADKMTMANSLELRVPFLDKVVFDV ASKIPDELKTKNGTTKYLLRKAAEGIVPEHVLNRKKLGFPVPIRHWLKNEMNEWVRNI IQESQTDAYIHKDYVLQLLEDHCADKADNSRKIWTVLIFMIWHSINIEKRYMPEELSH QPKEVIFV*" /label="asnB CDS" gene complement(2644022..2645920) /gene="asnB" /locus_tag="BSU_30540" /old_locus_tag="BSU30540" /label="asnB gene" promotor_-35 2645078..2645084 /Source="Nicolas_upshift_promotors" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2645099..2645110 /Source="Nicolas_upshift_promotors" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2645111 /Source="Nicolas_upshifts" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2645921..2646044) /Source="Nicolas_S_feature" /locus_tag="new_3127676_3127799_c" /HighExp="Paraq, G135, G180, G150, Oxctl, LBGexp, BMM, dia0, Heat, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.632, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1166" CDS complement(2646070..2647272) /gene="metK" /locus_tag="BSU_30550" /old_locus_tag="BSU30550" /EC_number="2.5.1.6" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8755891, 10094622, 12910260, 16672621, 18634909" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755891, 10094622, 12910260, 16672621, 18634909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine synthetase" /protein_id="NP_390933.1" /db_xref="EnsemblGenomes-Gn:BSU30550" /db_xref="EnsemblGenomes-Tr:CAB15033" /db_xref="GOA:P54419" /db_xref="InterPro:IPR002133" /db_xref="InterPro:IPR022628" /db_xref="InterPro:IPR022629" /db_xref="InterPro:IPR022630" /db_xref="InterPro:IPR022631" /db_xref="InterPro:IPR022636" /db_xref="SubtiList:BG11840" /db_xref="UniProtKB/Swiss-Prot:P54419" /translation="MSKNRRLFTSESVTEGHPDKICDQISDSILDEILKKDPNARVAC ETSVTTGLVLVSGEITTSTYVDIPKTVRQTIKEIGYTRAKYGFDAETCAVLTSIDEQS ADIAMGVDQALEAREGTMSDEEIEAIGAGDQGLMFGYACNETKELMPLPISLAHKLAR RLSEVRKEDILPYLRPDGKTQVTVEYDENNKPVRIDAIVISTQHHPEITLEQIQRNIK EHVINPVVPEELIDEETKYFINPTGRFVIGGPQGDAGLTGRKIIVDTYGGYARHGGGA FSGKDATKVDRSAAYAARYVAKNIVAAELADSCEVQLAYAIGVAQPVSISINTFGSGK ASEEKLIEVVRNNFDLRPAGIIKMLDLRRPIYKQTAAYGHFGRHDVDLPWERTDKAEQ LRKEALGE*" /label="metK CDS" gene complement(2646070..2647272) /gene="metK" /locus_tag="BSU_30550" /old_locus_tag="BSU30550" /label="metK gene" downshifts complement(2646089) /Source="Nicolas_upshifts" /id="D1573" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="7.14538" /MaxDrop="3.78097" /score="-4.044113" /energy="-12.1" /TU="U2367,U2368" /idTUdmin="U2367" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2647315..2647326) /Source="Nicolas_upshift_promotors" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2647321) /Source="Nicolas_upshifts" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2647323..2647439) /Source="Nicolas_S_feature" /locus_tag="new_3129078_3129194_c" /HighExp="G180, Paraq, G150, Oxctl, G135, BMM, LBGexp, HPh, MG-0.2, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1167" promotor_-35 complement(2647340..2647346) /Source="Nicolas_upshift_promotors" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA complement(2647440..2647578) /gene="mswG" /locus_tag="BSU_misc_RNA_50" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswG RNA" gene complement(2647440..2647578) /gene="mswG" /locus_tag="BSU_misc_RNA_50" /label="mswG gene" downshifts 2647538 /Source="Nicolas_upshifts" /id="D1574" /incds=0 /nref=3 /ntot=20 /MaxReadThrough="1.15866" /MaxDrop="4.97875" /score="11.8729615" /energy="-16.6" /TU="NA" /idTUdmin="U2369" /TUdmin="-1841" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2647587..2647606) /Source="Nicolas_upshift_promotors" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="promotor_-10" upshifts complement(2647602) /Source="Nicolas_upshifts" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="upshifts" promotor_-35 complement(2647623..2647627) /Source="Nicolas_upshift_promotors" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="promotor_-35" promotor_-35 2647699..2647706 /Source="Nicolas_upshift_promotors" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2647718 /Source="Nicolas_upshifts" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2647720..2647739 /Source="Nicolas_upshift_promotors" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2647775..2649358 /gene="pckA" /locus_tag="BSU_30560" /old_locus_tag="BSU30560" /EC_number="4.1.1.49" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400158, 4146915, 15491857, 15720552, 18586936, 20933603, 23136871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoenolpyruvate carboxykinase" /protein_id="NP_390934.2" /db_xref="EnsemblGenomes-Gn:BSU30560" /db_xref="EnsemblGenomes-Tr:CAB15034" /db_xref="GOA:P54418" /db_xref="InterPro:IPR001272" /db_xref="InterPro:IPR008210" /db_xref="InterPro:IPR013035" /db_xref="InterPro:IPR015994" /db_xref="SubtiList:BG11841" /db_xref="UniProtKB/Swiss-Prot:P54418" /translation="MNSVDLTADLQALLTCPNVRHNLSAAQLTEKVLSRNEGILTSTG AVRATTGAYTGRSPKDKFIVEEESTKNKIDWGPVNQPISEEAFERLYTKVVSYLKERD ELFVFEGFAGADEKYRLPITVVNEFAWHNLFARQLFIRPEGNDKKTVEQPFTILSAPH FKADPKTDGTHSETFIIVSFEKRTILIGGTEYAGEMKKSIFSIMNFLLPERDILSMHC SANVGEKGDVALFFGLSGTGKTTLSADADRKLIGDDEHGWSDTGVFNIEGGCYAKCIH LSEEKEPQIFNAIRFGSVLENVVVDEDTREANYDDSFYTENTRAAYPIHMINNIVTPS MAGHPSAIVFLTADAFGVLPPISKLTKEQAMYHFLSGYTSKLAGTERGVTSPETTFST CFGSPFLPLPAHVYAEMLGKKIDEHGADVFLVNTGWTGGGYGTGERMKLSYTRAMVKA AIEGKLEDAEMITDDIFGLHIPAHVPGVPDHILQPENTWTNKEEYKEKAVYLANEFKE NFKKFAHTDAIAQAGGPLV*" /label="pckA CDS" gene 2647775..2649358 /gene="pckA" /locus_tag="BSU_30560" /old_locus_tag="BSU30560" /label="pckA gene" downshifts 2649347 /Source="Nicolas_upshifts" /id="D1575" /incds=0 /nref=106 /ntot=269 /MaxReadThrough="2.55056" /MaxDrop="8.3695" /score="11.8729615" /energy="-16.6" /TU="U2369" /idTUdmin="U2369" /TUdmin="-32" /isTUend="FALSE" /label="downshifts" CDS complement(2649397..2649639) /gene="ytmB" /locus_tag="BSU_30570" /old_locus_tag="BSU30570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390935.1" /db_xref="EnsemblGenomes-Gn:BSU30570" /db_xref="EnsemblGenomes-Tr:CAB15035" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019699" /db_xref="PDB:2NWA" /db_xref="SubtiList:BG13882" /db_xref="UniProtKB/Swiss-Prot:O34365" /translation="MGMPVEFNTLIVTKGKEVRIDENIFTLEKDGYRVYPMEIPMDVR KTKFGEKSGTAEVQKLQWEEGRTIITYKLTSLHSVN*" /label="ytmB CDS" gene complement(2649397..2649639) /gene="ytmB" /locus_tag="BSU_30570" /old_locus_tag="BSU30570" /label="ytmB gene" downshifts complement(2649411) /Source="Nicolas_upshifts" /id="D1576" /incds=0 /nref=170 /ntot=242 /MaxReadThrough="1.2088" /MaxDrop="5.1365" /score="38.3436505" /energy="-16.6" /TU="NA" /idTUdmin="U2371" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2649691..2650464) /gene="ytmA" /locus_tag="BSU_30580" /old_locus_tag="BSU30580" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27899916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative esterase" /protein_id="NP_390936.1" /db_xref="EnsemblGenomes-Gn:BSU30580" /db_xref="EnsemblGenomes-Tr:CAB15036" /db_xref="GOA:O34493" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR002471" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13881" /db_xref="UniProtKB/Swiss-Prot:O34493" /translation="MIVEKRRFPSPSQHVRLYTICYLSNGLRVKGLLAEPAEPGQYDG FLYLRGGIKSVGMVRPGRIIQFASQGFVVFAPFYRGNQGGEGNEDFAGEDREDAFSAF RLLQQHPNVKKDRIHIFGFSRGGIMGMLTAIEMGGQAASFVSWGGVSDMILTYEERQD LRRMMKRVIGGTPKKVPEEYQWRTPFDQVNKIQAPVLLIHGEKDQNVSIQHSYLLEEK LKQLHKPVETWYYSTFTHYFPPKENRRIVRQLTQWMKNR*" /label="ytmA CDS" gene complement(2649691..2650464) /gene="ytmA" /locus_tag="BSU_30580" /old_locus_tag="BSU30580" /label="ytmA gene" S_feature complement(2650465..2650555) /Source="Nicolas_S_feature" /locus_tag="new_3132220_3132310_c" /HighExp="S8, dia15, Diami, Etha, S7, dia5, H2O2, G180, Heat, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1168" promotor_-35 2650531..2650540 /Source="Nicolas_upshift_promotors" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2650544..2650563) /Source="Nicolas_upshift_promotors" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2650552 /Source="Nicolas_upshifts" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2650553..2650572 /Source="Nicolas_upshift_promotors" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2650557) /Source="Nicolas_upshifts" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2650578..2650585) /Source="Nicolas_upshift_promotors" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2650615..2651619 /gene="ytlA" /locus_tag="BSU_30595" /old_locus_tag="BSU30595" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC anion transporter component" /protein_id="NP_390937.2" /db_xref="EnsemblGenomes-Gn:BSU30595" /db_xref="EnsemblGenomes-Tr:CAB15037" /db_xref="GOA:C0SP84" /db_xref="SubtiList:BG13873" /db_xref="UniProtKB/Swiss-Prot:C0SP84" /translation="MNRWLRLGFACVGSIFLMFALAACKQEETLTKVKVAEVTHSIFY APLYVAESKGFFKEEGLDVDVNTTWGGDKTMTSLLSNGSDIALVGSETSIYVEAQGAK DPVINFAQLTQTDGTFLVAREDVEHFDWDQLKGKTFLGQRKGGMPQMVGEYVLNKHKI DPHKDIDLIQNIDFANIANAFASGTGEYVQLFEPQASLFEKKGIGHIVASFGEESGEV PYTTFMAKQSYLKKNEDTAVKFTKAIYKAQQWVENHSAKDITDAIKDEFDDTDPDVIE TSIERYKKQHSYSPDPLLNEKEWELLQTIMDKSGELPKHIPYNQLVNKEIAEKVTSEK *" /label="ytlA CDS" gene 2650615..2651619 /gene="ytlA" /locus_tag="BSU_30595" /old_locus_tag="BSU30595" /label="ytlA gene" CDS 2651632..2652414 /gene="ytlC" /locus_tag="BSU_30610" /old_locus_tag="BSU30610" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC anion transporter component, ATP-binding" /protein_id="NP_390939.1" /db_xref="EnsemblGenomes-Gn:BSU30610" /db_xref="EnsemblGenomes-Tr:CAB15039" /db_xref="GOA:O34314" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13875" /db_xref="UniProtKB/Swiss-Prot:O34314" /translation="MSFLHVDHVTHTYFSIKEKTTAVRDIHFDAEKGDFISFLGPSGC GKTTLLSIIAGLIEPSEGRVLIEGREPNQKEHNIGYMLQQDYLFPWKSIEENVLLGLK IADTLTEESKAAALGLLPEFGLIDVEKKYPKELSGGMRQRAALARTLAPNPSLLLLDE PFSALDFQTKLSLENLVFRTLKEYQKTAVLVTHDIGEAIAMSDTIFLFSNQPGTIHQI FTIPKELAAMLPFDARQEPSFQTLFQTIWKELNSLEKQQRNH*" /label="ytlC CDS" gene 2651632..2652414 /gene="ytlC" /locus_tag="BSU_30610" /old_locus_tag="BSU30610" /label="ytlC gene" S_feature complement(2651636..2653184) /Source="Nicolas_S_feature" /locus_tag="new_3133391_3134939_c" /HighExp="Cold, S8, G180, H2O2, G135, Paraq, G150, S7, Oxctl, LPh" /AntisenseName="ytlC" /AntisenseCor="0.110169300738282" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1169" CDS 2652389..2653201 /gene="ytlD" /locus_tag="BSU_30620" /old_locus_tag="BSU30620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease of ABC anion transporter" /protein_id="NP_390940.1" /db_xref="EnsemblGenomes-Gn:BSU30620" /db_xref="EnsemblGenomes-Tr:CAB15040" /db_xref="GOA:O34649" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13876" /db_xref="UniProtKB/Swiss-Prot:O34649" /translation="MRNSKETIDLLHEQYQFKQKKEKWKVHSFQLAIFILFFSGWEIS SRQGWIDPLIFSSPSAVWRLLLEKLGDGSLLSHIGVTLFETVLGFLLGTFMGTCLAAL LWWSNRLARILDPYLVILNAMPKVALGPILIVALGPSFISIIAMGAIISVIITTIVVY TAFQEVDENYTKVMKTFGAKKWVIFKEVILPASSPAIISTLKVNVGLSWVGVIVGEFL VSKVGLGYMIIYGFQVFNFTLVFLSLLIIAIFATLMYQGVELLEKKWTKGRT*" /label="ytlD CDS" gene 2652389..2653201 /gene="ytlD" /locus_tag="BSU_30620" /old_locus_tag="BSU30620" /label="ytlD gene" downshifts 2653186 /Source="Nicolas_upshifts" /id="D1577" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="3.58734" /MaxDrop="4.596" /score="38.1379668" /energy="-12.6" /TU="U2370" /idTUdmin="U2370" /TUdmin="-242" /isTUend="FALSE" /label="downshifts" CDS complement(2653228..2653704) /gene="rppG" /locus_tag="BSU_30630" /old_locus_tag="BSU30630" /EC_number="3.6.1.15" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576788, 16513759, 21925382, 23610407, 23610425, 27936487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576788, 16513759, 21925382, 23610407, 23610425, 27936487; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="nucleoside and RNA triphosphate phosphohydrolase" /protein_id="NP_390941.1" /db_xref="EnsemblGenomes-Gn:BSU30630" /db_xref="EnsemblGenomes-Tr:CAB15041" /db_xref="GOA:O35013" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR014078" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="PDB:4JZS" /db_xref="PDB:4JZT" /db_xref="PDB:4JZU" /db_xref="PDB:4JZV" /db_xref="SubtiList:BG13869" /db_xref="UniProtKB/Swiss-Prot:O35013" /translation="MYEFKDYYQNTVQLSFDDQPFSDSPKHVWVICRFGGKWLLTEHE DRGYEFPGGKVEPMECAEEAALREVKEETGARVKSLKYLGQYKVLGKEKVIVKNIYFA DIEKLEKQADYFETKGPVLFHELPENLSRNKKFSFIMKDSVLPISLKKLKESGWIE*" /label="rppG CDS" gene complement(2653228..2653704) /gene="rppG" /locus_tag="BSU_30630" /old_locus_tag="BSU30630" /label="rppG gene" downshifts complement(2653229) /Source="Nicolas_upshifts" /id="D1578" /incds=0 /nref=171 /ntot=265 /MaxReadThrough="4.52721" /MaxDrop="6.99686" /score="36.2618206" /energy="-12.6" /TU="U2372" /idTUdmin="U2373" /TUdmin=11 /isTUend="TRUE" /label="downshifts" misc_feature complement(2653734..2653753) /Source="Nicolas_upshift_promotors" /id="U2372" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.935064935064935" /psig=1 /xcortree=2134 /SigmaFactorBS="cggcgtgctgggtttcccttattttttgataaaaggcttccg aagaaacgtaacTGTGGTATGATGTATGGAAGatagctaggaacggatttgagggata a" /listShort="ytkD, S1169" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2653747) /Source="Nicolas_upshifts" /id="U2372" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.935064935064935" /psig=1 /xcortree=2134 /SigmaFactorBS="cggcgtgctgggtttcccttattttttgataaaaggcttccg aagaaacgtaacTGTGGTATGATGTATGGAAGatagctaggaacggatttgagggata a" /listShort="ytkD, S1169" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2653749..2653883) /Source="Nicolas_S_feature" /locus_tag="new_3135504_3135638_c" /HighExp="BT, B36, S8, S5, S7, Etha, S6, S4, B60, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigK, SigB" /TUshortPSig="0.909, 1, 0.994" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.994" /label="S1170" upshifts complement(2653883) /Source="Nicolas_upshifts" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2653885..2653896) /Source="Nicolas_upshift_promotors" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2653911..2653917) /Source="Nicolas_upshift_promotors" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2653913..2654317) /gene="ytkC" /locus_tag="BSU_30640" /old_locus_tag="BSU30640" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative autolytic amidase" /protein_id="NP_390942.1" /db_xref="EnsemblGenomes-Gn:BSU30640" /db_xref="EnsemblGenomes-Tr:CAB15042" /db_xref="GOA:O34883" /db_xref="InterPro:IPR006480" /db_xref="SubtiList:BG13868" /db_xref="UniProtKB/Swiss-Prot:O34883" /translation="MDRDFGIFSFLAVSVSAAGFFFGGFQYSFLILLSLMAIEFISTT LKETIIHKLSFKKVFARLVKKLVTLALISVCHFFDQLLNTQGSIRDLAIMFYILYESV QIVVTASSLGIPVPQMLVDLLETLKNKFKRKP*" /label="ytkC CDS" gene complement(2653913..2654317) /gene="ytkC" /locus_tag="BSU_30640" /old_locus_tag="BSU30640" /label="ytkC gene" promotor_-10 complement(2654345..2654364) /Source="Nicolas_upshift_promotors" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2654362) /Source="Nicolas_upshifts" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2654364..2654450) /Source="Nicolas_S_feature" /locus_tag="new_3136119_3136205_c" /HighExp="Etha, B36, S8, B60, S7, LoTm, Salt, Sw, Gly, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.994" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.994" /label="S1171" promotor_-35 complement(2654377..2654386) /Source="Nicolas_upshift_promotors" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2654483..2654920) /gene="dps" /locus_tag="BSU_30650" /old_locus_tag="BSU30650" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12767829, 16091047, 16861227, 16935006; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-protecting protein, mini-ferritin" /protein_id="NP_390943.1" /db_xref="EnsemblGenomes-Gn:BSU30650" /db_xref="EnsemblGenomes-Tr:CAB15043" /db_xref="GOA:P80879" /db_xref="InterPro:IPR002177" /db_xref="InterPro:IPR008331" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR023188" /db_xref="SubtiList:BG12584" /db_xref="UniProtKB/Swiss-Prot:P80879" /translation="MSEQLIQAVNKQVANWTVMYVKLHNYHWYVKGKDFFTLHEKFEE LYNETATYIDDLAERLLALNGKPIATMKESLETASVKEAAGNETAEQMVQSVYDDFTV IAEELKNGMDLADEVGDETTGDMLLAIHQNIEKHNWMLKAYLG*" /label="dps CDS" gene complement(2654483..2654920) /gene="dps" /locus_tag="BSU_30650" /old_locus_tag="BSU30650" /label="dps gene" downshifts complement(2654495) /Source="Nicolas_upshifts" /id="D1579" /incds=0 /nref=188 /ntot=382 /MaxReadThrough="3.87056" /MaxDrop="7.83664" /score="36.0931083" /energy="-19.2" /TU="U2375" /idTUdmin="U2377" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2654937..2654955) /Source="Nicolas_upshift_promotors" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2654955) /Source="Nicolas_upshifts" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2654957..2655182) /Source="Nicolas_S_feature" /locus_tag="new_3136712_3136937_c" /HighExp="M0t90, Lbstat, M40t90, ferm, S2, nit, M40t45, S0, Lbtran, BT" /AntisenseName="ytzI" /AntisenseCor="-0.30531150128448598" /AntisenseRegPval="-6.5" /CDS_PredictionProba="0.38276900000000003" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.999, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S1172" promotor_-35 complement(2654970..2654976) /Source="Nicolas_upshift_promotors" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2655012..2655031 /Source="Nicolas_upshift_promotors" /id="U2376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig="0.999000999001" /xcortree=436 /SigmaFactorBS="ccttaatatcgtacgctaaaacctcttttttacccttatctg tcacgatttcttctatTATGCTACAATTGTTAAAAAacgggaggtggaatgtcatgac g" /listShort="ytzI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 2655013..2655189 /gene="ytzI" /locus_tag="BSU_30659" /old_locus_tag="BSU30659" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097774.1" /db_xref="EnsemblGenomes-Gn:BSU30659" /db_xref="EnsemblGenomes-Tr:CAX52680" /db_xref="GOA:C0H3Q1" /db_xref="InterPro:IPR022248" /db_xref="UniProtKB/Swiss-Prot:C0H3Q1" /translation="MLQLLKNGRWNVMTLLITISILIVLAVLLVTIWTTVKAYNVKHT IDPPQENHSDSHNQ*" /label="ytzI CDS" gene 2655013..2655189 /gene="ytzI" /locus_tag="BSU_30659" /old_locus_tag="BSU30659" /label="ytzI gene" upshifts 2655014 /Source="Nicolas_upshifts" /id="U2376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig="0.999000999001" /xcortree=436 /SigmaFactorBS="ccttaatatcgtacgctaaaacctcttttttacccttatctg tcacgatttcttctatTATGCTACAATTGTTAAAAAacgggaggtggaatgtcatgac g" /listShort="ytzI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2655183..2655620) /gene="ytkA" /locus_tag="BSU_30660" /old_locus_tag="BSU30660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390944.1" /db_xref="EnsemblGenomes-Gn:BSU30660" /db_xref="EnsemblGenomes-Tr:CAB15044" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR032693" /db_xref="SubtiList:BG11027" /db_xref="UniProtKB/Swiss-Prot:P40768" /translation="MKKMLVVLLFSALLLNGCGSGESKANTAETPEVLDVKLTGPEKV NPGESAAYEAAVSYGDEAVTDADEVEFEVWKEGEKDASQMFKVKQEKGVYRLETTFKE DGVYTVQSHVTAKKQHSMPTLKVQVGDADAASNQSEEEHSHHH*" /label="ytkA CDS" gene complement(2655183..2655620) /gene="ytkA" /locus_tag="BSU_30660" /old_locus_tag="BSU30660" /label="ytkA gene" downshifts 2655209 /Source="Nicolas_upshifts" /id="D1580" /incds=0 /nref=37 /ntot=155 /MaxReadThrough="2.0116" /MaxDrop="3.95427" /score="13.1411485" /energy="-20.5" /TU="NA" /idTUdmin="U2376" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2655639..2655658) /Source="Nicolas_upshift_promotors" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="promotor_-10" upshifts complement(2655660) /Source="Nicolas_upshifts" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="upshifts" promotor_-35 complement(2655669..2655677) /Source="Nicolas_upshift_promotors" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="promotor_-35" CDS complement(2655740..2656213) /gene="luxS" /locus_tag="BSU_30670" /old_locus_tag="BSU30670" /EC_number="4.4.1.21" /function="16.5: Explore" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11601850, 15287744, 15751951, 16740951, 17056751, 22720735, 22938038, 26779171, 28342077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11601850, 15287744, 15751951, 16740951, 17056751, 22720735, 22938038, 26779171, 28342077; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-ribosylhomocysteine lyase" /protein_id="NP_390945.1" /db_xref="EnsemblGenomes-Gn:BSU30670" /db_xref="EnsemblGenomes-Tr:CAB15045" /db_xref="GOA:O34667" /db_xref="InterPro:IPR003815" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR037005" /db_xref="PDB:1IE0" /db_xref="PDB:1J98" /db_xref="PDB:1JQW" /db_xref="PDB:1JVI" /db_xref="PDB:1YCL" /db_xref="PDB:2FQO" /db_xref="PDB:2FQT" /db_xref="SubtiList:BG13866" /db_xref="UniProtKB/Swiss-Prot:O34667" /translation="MPSVESFELDHNAVVAPYVRHCGVHKVGTDGVVNKFDIRFCQPN KQAMKPDTIHTLEHLLAFTIRSHAEKYDHFDIIDISPMGCQTGYYLVVSGEPTSAEIV DLLEDTMKEAVEITEIPAANEKQCGQAKLHDLEGAKRLMRFWLSQDKEELLKVFG*" /label="luxS CDS" gene complement(2655740..2656213) /gene="luxS" /locus_tag="BSU_30670" /old_locus_tag="BSU30670" /label="luxS gene" downshifts complement(2655749) /Source="Nicolas_upshifts" /id="D1581" /incds=0 /nref=72 /ntot=201 /MaxReadThrough="4.53626" /MaxDrop="4.63695" /score="14.8438415" /energy="-14.2" /TU="U2379,U2380" /idTUdmin="U2380" /TUdmin="-793" /isTUend="FALSE" /label="downshifts" downshifts complement(2655836) /Source="Nicolas_upshifts" /id="D1582" /incds=1 /nref=1 /ntot=96 /MaxReadThrough="5.57623" /MaxDrop="2.4806" /score="14.8438415" /energy="-14.2" /TU="U2379,U2380" /idTUdmin="U2380" /TUdmin="-880" /isTUend="FALSE" /label="downshifts" S_feature complement(2656214..2656565) /Source="Nicolas_S_feature" /locus_tag="new_3137969_3138320_c" /HighExp="Etha, B36, B60, BMM, S2, Heat, S1, LoTm, Lbtran, S5" /AntisenseName="ytjA" /AntisenseCor="-0.45038987072908898" /AntisenseRegPval="-14.1" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S1173" promotor_-35 2656285..2656292 /Source="Nicolas_upshift_promotors" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2656305..2656324 /Source="Nicolas_upshift_promotors" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2656310 /Source="Nicolas_upshifts" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2656342..2656569 /gene="ytjA" /locus_tag="BSU_30680" /old_locus_tag="BSU30680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 19306042, 21803992; Product type f: factor" /codon_start=1 /transl_table=11 /product="membrane protein insertion efficiency factor" /protein_id="NP_390946.1" /db_xref="EnsemblGenomes-Gn:BSU30680" /db_xref="EnsemblGenomes-Tr:CAB15046" /db_xref="GOA:O34601" /db_xref="InterPro:IPR002696" /db_xref="SubtiList:BG13865" /db_xref="UniProtKB/Swiss-Prot:O34601" /translation="MKTLFIALIRGYQKFISPLTPPTCRFYPTCSQYGIEAIKTHGAL KGGWLTIKRILKCHPFHPGGVDPVPEKKQKH*" /label="ytjA CDS" gene 2656342..2656569 /gene="ytjA" /locus_tag="BSU_30680" /old_locus_tag="BSU30680" /label="ytjA gene" CDS complement(2656566..2657129) /gene="ytiB" /locus_tag="BSU_30690" /old_locus_tag="BSU30690" /EC_number="4.2.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12193617, 21266987; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carbonic anhydrase" /protein_id="NP_390947.1" /db_xref="EnsemblGenomes-Gn:BSU30690" /db_xref="EnsemblGenomes-Tr:CAB15047" /db_xref="GOA:O34872" /db_xref="InterPro:IPR001765" /db_xref="InterPro:IPR036874" /db_xref="SubtiList:BG13863" /db_xref="UniProtKB/Swiss-Prot:O34872" /translation="MSLLNDILEFNKTFTEQREYEKYQTSKFPDKKMAILSCMDTRLV ELLPHAMNLRNGDVKIIKSAGALVTHPFGSIMRSILVAVYELNADEVCVIGHHDCGMS KISSKSMLEKIKARGIPEERIETIKYSGVDFDQWFKSFDSVEASVKDSVDVIKHHPLF PENVPVHGLVIDPKTGKLDLIVNGYNN*" /label="ytiB CDS" gene complement(2656566..2657129) /gene="ytiB" /locus_tag="BSU_30690" /old_locus_tag="BSU30690" /label="ytiB gene" misc_feature complement(2657154..2657173) /Source="Nicolas_upshift_promotors" /id="U2379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2374 /SigmaFactorBS="gaaataaggcaggcctgagggtttgtctttttttattatgac gaataaacaagggtTGTGATATATTGAAGAGTAAaaagaatagaaagggacaacgaac a" /listShort="ytiB, S1173, luxS, ytkA, S1172, dps" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2657169) /Source="Nicolas_upshifts" /id="U2379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2374 /SigmaFactorBS="gaaataaggcaggcctgagggtttgtctttttttattatgac gaataaacaagggtTGTGATATATTGAAGAGTAAaaagaatagaaagggacaacgaac a" /listShort="ytiB, S1173, luxS, ytkA, S1172, dps" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2657223..2657471) /gene="rpmEB" /locus_tag="BSU_30700" /old_locus_tag="BSU30700" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15049826, 16014871, 16547061, 19648245, 20208344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15049826, 16014871, 16547061, 19648245, 20208344; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L31" /protein_id="NP_390948.1" /db_xref="EnsemblGenomes-Gn:BSU30700" /db_xref="EnsemblGenomes-Tr:CAB15048" /db_xref="GOA:O34967" /db_xref="InterPro:IPR002150" /db_xref="InterPro:IPR027493" /db_xref="InterPro:IPR034704" /db_xref="SubtiList:BG13862" /db_xref="UniProtKB/Swiss-Prot:O34967" /translation="MKEGIHPKNHKVIFQDVNSGYRFLSTSTKTSNETAEWEDGNTYP VIKVEVSSDTHPFYTGRQKFNEKGGRVEQFKKRYNMGK*" /label="rpmEB CDS" gene complement(2657223..2657471) /gene="rpmEB" /locus_tag="BSU_30700" /old_locus_tag="BSU30700" /label="rpmEB gene" downshifts complement(2657244) /Source="Nicolas_upshifts" /id="D1583" /incds=0 /nref=96 /ntot=217 /MaxReadThrough="7.96356" /MaxDrop="4.50701" /score="15.8096104" /energy="-7.5" /TU="U2380" /idTUdmin="U2380" /TUdmin="-2288" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2657499..2657518) /Source="Nicolas_upshift_promotors" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="promotor_-10" promotor_-35 complement(2657532..2657539) /Source="Nicolas_upshift_promotors" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="promotor_-35" upshifts complement(2657536) /Source="Nicolas_upshifts" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="upshifts" promotor_-35 2657598..2657604 /Source="Nicolas_upshift_promotors" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="promotor_-35" promotor_-10 2657618..2657629 /Source="Nicolas_upshift_promotors" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="promotor_-10" upshifts 2657630 /Source="Nicolas_upshifts" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="upshifts" CDS 2657676..2659007 /gene="ythA" /locus_tag="BSU_30710" /old_locus_tag="BSU30710" /EC_number="1.10.3.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9852001, 10551842, 15849754, 16850406, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cytochrome bd menaquinol oxidase subunit I" /protein_id="NP_390949.2" /db_xref="EnsemblGenomes-Gn:BSU30710" /db_xref="EnsemblGenomes-Tr:CAB15049" /db_xref="GOA:C0SP90" /db_xref="InterPro:IPR002585" /db_xref="SubtiList:BG13857" /db_xref="UniProtKB/Swiss-Prot:C0SP90" /translation="MDDLVLARSLFGTTMGFHIIFATLGVGLPLMILVAELIYQKTKD DHYAIMAKRWTKAQAVLLGVAIPTGTIAGTQLALLWPGFMEVIGRVMSLPFQIEIYAF FVEALFMSIYVYAADRLSPAMRIVAVFFVLVGAAASAVLITNVHAFEGTPAGFKILNG KITDVDPWAAFFNPSFFITAGHVVLSAFMTGAFIVASVAAYKMIRTRKKERVYRFHRK ALLLALTIGGIFSLLTALNGHESAQMLYEYQPEKLAGAEGLFETRSHAPLAIGGFTDP NEEKVKWAIEIPWALSFLAANRFDTVVKGLNAFPRDEWPPLFIHTLFNAMVGVGMLLI LYSIIGVVWRKVLKKDRFPTWLLIIFMTAGPFSLIGIEFGWIFACTGRQPWVIYHLLK TSDVVTTTGSIGVLFLFFTFVYAVLGAAVVYVLLYYFRKHPVDEDLNTAES*" /label="ythA CDS" gene 2657676..2659007 /gene="ythA" /locus_tag="BSU_30710" /old_locus_tag="BSU30710" /label="ythA gene" CDS 2659051..2660091 /gene="ythB" /locus_tag="BSU_30720" /old_locus_tag="BSU30720" /EC_number="1.10.3.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11073895, 15576792, 15849754, 16850406, 10551842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cytochrome bd menaquinol oxidase subunit II" /protein_id="NP_390950.1" /db_xref="EnsemblGenomes-Gn:BSU30720" /db_xref="EnsemblGenomes-Tr:CAB15050" /db_xref="GOA:O34505" /db_xref="InterPro:IPR003317" /db_xref="SubtiList:BG13858" /db_xref="UniProtKB/Swiss-Prot:O34505" /translation="MEISTDALIAISIIWGFVFIYAVMATMDFGAGFWSMIYLNKEHM KATDIANRFLSPTWEVTNVFIVAIVVALFSFFPGATFVLGTVLLIPGSMILLLLAIRS GFLVFSNTAKERKTLRYISGISGFIIPAILILVLPVTHGGFIEKTDGIYNLNMSKIFS SPNAYSFIGFAILSTLFLSSLLLADFSNVAEEQDAYRAYRKSALITGPISLLFAVCIM VTMRNEANWLYSGMMNDFSWIIASFITFVIAGIALFLPNKSFGQNIGKPRLALVAIGI QYFLASYAYGRAHLPYMIYPDVTVMSGFTEPATFRALFATYIVAFIILFPGFFFFWKM FMRDKRYIRQEE*" /label="ythB CDS" gene 2659051..2660091 /gene="ythB" /locus_tag="BSU_30720" /old_locus_tag="BSU30720" /label="ythB gene" promotor_-35 2660085..2660091 /Source="Nicolas_upshift_promotors" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2660106..2660117 /Source="Nicolas_upshift_promotors" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2660116 /Source="Nicolas_upshifts" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="upshifts" CDS 2660145..2660303 /gene="ytzL" /locus_tag="BSU_30739" /old_locus_tag="BSU30739" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097775.1" /db_xref="EnsemblGenomes-Gn:BSU30739" /db_xref="EnsemblGenomes-Tr:CAX52681" /db_xref="InterPro:IPR011437" /db_xref="UniProtKB/Swiss-Prot:C0H3Q2" /translation="MEQKILCEVNNCSYWGKGNKCTADAIYVVSHTGETAENSRETDC KTFKPHDL*" /label="ytzL CDS" gene 2660145..2660303 /gene="ytzL" /locus_tag="BSU_30739" /old_locus_tag="BSU30739" /label="ytzL gene" downshifts 2660292 /Source="Nicolas_upshifts" /id="D1584" /incds=0 /nref=55 /ntot=88 /MaxReadThrough="1.7679" /MaxDrop="7.01398" /score="-5.86934022" /energy="-7" /TU="NA" /idTUdmin="U2382" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2660322..2661209) /gene="mntD" /locus_tag="BSU_30740" /old_locus_tag="BSU30740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:49350, 15849754, 15948947, 16566604, 16704341, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 49350, 15849754, 15948947, 16566604, 16704341, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (permease)" /protein_id="NP_390952.1" /db_xref="EnsemblGenomes-Gn:BSU30740" /db_xref="EnsemblGenomes-Tr:CAB15052" /db_xref="GOA:O34500" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG13854" /db_xref="UniProtKB/Swiss-Prot:O34500" /translation="MSFEAWIIATGVLVGVSCGLIGTFLVLRSMAMLADAISHTVLLG IVGAFLVTGSLDGIYMFIGAAATGLLTAFLVQLLHSKGVQSDAAIGVVFTSLFAIGVI LLSVYGANVHLDIEHSLMGEIAFVPWNTVTVFGVDIGPKAFWMLASVLVLNVVLISVC YKEFKIASFDPQMALALGIPVLLIHYVQMGMLSLTTVASFDSVGAVLVVAMLIVPPAA AHLLTDRLLYMLILSALIGGLSAVMGYFFATWLNVSISGAMAAMTGVCYASAFLFSPA NGVITKKLRTLNMQKERAG*" /label="mntD CDS" gene complement(2660322..2661209) /gene="mntD" /locus_tag="BSU_30740" /old_locus_tag="BSU30740" /label="mntD gene" downshifts complement(2660345) /Source="Nicolas_upshifts" /id="D1585" /incds=0 /nref=121 /ntot=218 /MaxReadThrough="3.39755" /MaxDrop="6.80546" /score="-8.37820006" /energy="-7" /TU="U2385" /idTUdmin="U2385" /TUdmin="-637" /isTUend="FALSE" /label="downshifts" CDS complement(2661199..2662506) /gene="mntC" /locus_tag="BSU_30750" /old_locus_tag="BSU30750" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:49350, 15849754, 15948947, 16566604, 16704341, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 49350, 15849754, 15948947, 16566604, 16704341, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (permease)" /protein_id="NP_390953.1" /db_xref="EnsemblGenomes-Gn:BSU30750" /db_xref="EnsemblGenomes-Tr:CAB15053" /db_xref="GOA:O35024" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13853" /db_xref="UniProtKB/Swiss-Prot:O35024" /translation="MFESLWLQLQHPNTQWVLAGTLLLGTASGVLGSFVLLRKQSLIG DAMAHSALPGVCLAFLFTGQKSLPFFLLGAALAGLLGTFCIQLIPRLSKTKEDSAIGI VLSVFFGVGIILLTYIQQQGAGSQSGLDSFLFGQAASLVRQDIILIAGISAVLLLLCI VFFKEFTLITFDLAFAKGLGIPVRFLNGLLACLIVCAVVIGLQTVGVILMAAMLITPA ITARYWTERLTGMIIIAGITGGVSGVAGTLLSTTMKGMATGPLMILSATLLFLFSMIC APKRGLAAKAIRLMRLRRRTSREQVLLAIYEQYEKNNLCVTVESVRKKRRLSPSLCLK ALNDLEQERCIERIENGIWQITSKGIEKGYHTALKQRMYEVYLMHEMELANIESDQDY FDPDRLPRETRERLYSLLKLYGRMPERRKASHDAEKGQIANEF*" /label="mntC CDS" gene complement(2661199..2662506) /gene="mntC" /locus_tag="BSU_30750" /old_locus_tag="BSU30750" /label="mntC gene" CDS complement(2662512..2663264) /gene="mntB" /locus_tag="BSU_30760" /old_locus_tag="BSU30760" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10760146, 15948947, 16566604, 16704341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10760146, 15948947, 16566604, 16704341; Product type t: transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (ATP-binding protein)" /protein_id="NP_390954.1" /db_xref="EnsemblGenomes-Gn:BSU30760" /db_xref="EnsemblGenomes-Tr:CAB15054" /db_xref="GOA:O34338" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13852" /db_xref="UniProtKB/Swiss-Prot:O34338" /translation="MFPVELDNVTVAYHKKPVLQDISLQVPEGKLIGIIGPNGAGKST LIKTILGLVPRASGDISIYGKDYKDQRTRIGYVPQRGSVDWDFPTSPLDVVLMGRYGR IGLLKRPKKADVEMAKAALTKVGMHDYAKRQISQLSGGQQQRVFLARALCQNADIYFM DEPFAGVDAATERAIMTLLAELKEKGKTVLVVHHDLQTAEDYFDWILLLHLRKIAFGP TENVFTIENLQKTYGGRLTFLKDKVLAEGHKE*" /label="mntB CDS" gene complement(2662512..2663264) /gene="mntB" /locus_tag="BSU_30760" /old_locus_tag="BSU30760" /label="mntB gene" CDS complement(2663283..2664203) /gene="mntA" /locus_tag="BSU_30770" /old_locus_tag="BSU30770" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10760146, 15948947, 16566604, 16704341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10760146, 15948947, 16566604, 16704341; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (manganese binding lipoprotein)" /protein_id="NP_390955.1" /db_xref="EnsemblGenomes-Gn:BSU30770" /db_xref="EnsemblGenomes-Tr:CAB15055" /db_xref="GOA:O34385" /db_xref="InterPro:IPR006127" /db_xref="InterPro:IPR006128" /db_xref="InterPro:IPR006129" /db_xref="SubtiList:BG13851" /db_xref="UniProtKB/Swiss-Prot:O34385" /translation="MRQGLMAAVLFATFALTGCGTDSAGKSADQQLQVTATTSQIADA AENIGGKHVKVTSLMGPGVDPHLYKASQGDTKKLMSADVVLYSGLHLEGKMEDVLQKI GEQKQSAAVAEAIPKNKLIPAGEGKTFDPHVWFSIPLWIYAVDEIEAQFSKAMPQHAD AFRKNAKEYKEDLQYLDKWSRKEIAHIPEKSRVLVTAHDAFAYFGNEYGFKVKGLQGL STDSDYGLRDVQELVDLLTEKQIKAVFVESSVSEKSINAVVEGAKEKGHTVTIGGQLY SDAMGEKGTKEGTYEGMFRHNINTITKALK*" /label="mntA CDS" gene complement(2663283..2664203) /gene="mntA" /locus_tag="BSU_30770" /old_locus_tag="BSU30770" /label="mntA gene" promotor_-10 complement(2664239..2664250) /Source="Nicolas_upshift_promotors" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2664240) /Source="Nicolas_upshifts" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2664242..2664333) /Source="Nicolas_S_feature" /locus_tag="new_3145997_3146088_c" /HighExp="T-0.40H, Sw, T-1.40H, BC, C90, C30, BI, T0.0H, T-3.40H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.985, 0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1174" promotor_-35 complement(2664264..2664270) /Source="Nicolas_upshift_promotors" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2664318 /Source="Nicolas_upshifts" /id="U2384" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.649350649350649" /psig="0.0549450549450549" /xcortree=296 /SigmaFactorBS="tcttagacatgtgacattaaattagccaaaagcatgttttat ttacacaggacaaaaagtttcCCTCATGCAAAATtatcgcgtttggccatttttgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2664319..2664338) /Source="Nicolas_upshift_promotors" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2664321..2664333 /Source="Nicolas_upshift_promotors" /id="U2384" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.649350649350649" /psig="0.0549450549450549" /xcortree=296 /SigmaFactorBS="tcttagacatgtgacattaaattagccaaaagcatgttttat ttacacaggacaaaaagtttcCCTCATGCAAAATtatcgcgtttggccatttttgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2664333) /Source="Nicolas_upshifts" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2664335..2664416) /Source="Nicolas_S_feature" /locus_tag="new_3146090_3146171_c" /HighExp="T1.30H, T1.0H, C30, T0.30H, T2.0H, T2.30H, T-0.40H, T-1.40H, T-2.40H, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1175" promotor_-35 complement(2664353..2664360) /Source="Nicolas_upshift_promotors" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2664416) /Source="Nicolas_upshifts" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="upshifts" promotor_-10 complement(2664425..2664444) /Source="Nicolas_upshift_promotors" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="promotor_-10" promotor_-35 complement(2664458..2664465) /Source="Nicolas_upshift_promotors" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="promotor_-35" CDS complement(2664483..2665598) /gene="menC" /locus_tag="BSU_30780" /old_locus_tag="BSU30780" /EC_number="4.2.1.113" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 8566759, 9139683, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8566759, 9139683, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="O-succinylbenzoate-CoA synthase" /protein_id="NP_390956.1" /db_xref="EnsemblGenomes-Gn:BSU30780" /db_xref="EnsemblGenomes-Tr:CAB15056" /db_xref="GOA:O34514" /db_xref="InterPro:IPR010197" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG13847" /db_xref="UniProtKB/Swiss-Prot:O34514" /translation="MIEIEKITLYHLSMNLKKPFKNSIETLQERKFLIVEAIDTSGVT GWGEVSAFSSPWYTEETIGTCLHMLKDFFIPNVVGREFNHPSEVPDSLARYKGNRMAK AGLESAVWDIYAKKKGVSLAEALGGTRDKVPAGVVVGLAPLDDMLKEIESYQKEGYQR IKIKIQPGQDVELVKAIRSRFPTIPLMADANSSYELKDISRLKELDDYHLMMIEQPLQ ADDIVDHRHLQKHLKTAICLDESICSVDDARRAIELGSCKIINIKPSRVGGLTEALKI HDLCKEHHMQVWCGGMLETGISRAQNVALASLPQFTIPGDISSSSRYWDEDIVTPDIR IDNGFISVSKQPGLGVEVNQDIMRKYVTKMDVFTQHG*" /label="menC CDS" gene complement(2664483..2665598) /gene="menC" /locus_tag="BSU_30780" /old_locus_tag="BSU30780" /label="menC gene" downshifts complement(2664526) /Source="Nicolas_upshifts" /id="D1586" /incds=0 /nref=12 /ntot=179 /MaxReadThrough="3.8638" /MaxDrop="2.96378" /score="29.7201414" /energy="-11.1" /TU="U2387,U2388" /idTUdmin="U2388" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2665595..2667055) /gene="menE" /locus_tag="BSU_30790" /old_locus_tag="BSU30790" /EC_number="6.2.1.26" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6780514, 6780515, 8566759, 9139683, 12682299, 28559280" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 6780515, 8566759, 9139683, 12682299, 28559280; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="O-succinylbenzoic acid-CoA ligase" /protein_id="NP_390957.1" /db_xref="EnsemblGenomes-Gn:BSU30790" /db_xref="EnsemblGenomes-Tr:CAB15057" /db_xref="GOA:P23971" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR010192" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:5BUQ" /db_xref="PDB:5BUR" /db_xref="PDB:5BUS" /db_xref="PDB:5GTD" /db_xref="PDB:5X8F" /db_xref="PDB:5X8G" /db_xref="SubtiList:BG10687" /db_xref="UniProtKB/Swiss-Prot:P23971" /translation="MLTEQPNWLMQRAQLTPERIALIYEDQTVTFAELFAASKRMAEQ LAAHSVRKGDTAAILLQNRAEMVYAVHACFLLGVKAVLLNTKLSTHERLFQLEDSGSG FLLTDSSFEKKEYEHIVQTIDVDELMKEAAEEIEIEAYMQMDATATLMYTSGTTGKPK GVQQTFGNHYFSAVSSALNLGITEQDRWLIALPLFHISGLSALFKSVIYGMTVVLHQR FSVSDVLHSINRHEVTMISAVQTMLASLLEETNRCPESIRCILLGGGPAPLPLLEECR EKGFPVFQSYGMTETCSQIVTLSPEFSMEKLGSAGKPLFSCEIKIERDGQVCEPYEHG EIMVKGPNVMKSYFNRESANEASFQNGWLKTGDLGYLDNEGFLYVLDRRSDLIISGGE NIYPAEVESVLLSHPAVAEAGVSGAEDKKWGKVPHAYLVLHKPVSAGELTDYCKERLA KYKIPAKFFVLDRLPRNASNKLLRNQLKDARKGELL*" /label="menE CDS" gene complement(2665595..2667055) /gene="menE" /locus_tag="BSU_30790" /old_locus_tag="BSU30790" /label="menE gene" promotor_-10 complement(2666498..2666516) /Source="Nicolas_upshift_promotors" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2666502) /Source="Nicolas_upshifts" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2666531..2666537) /Source="Nicolas_upshift_promotors" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2667144) /Source="Nicolas_upshifts" /id="D1587" /incds=0 /nref=1 /ntot=97 /MaxReadThrough="4.92536" /MaxDrop="2.4145" /score="1.01127104" /energy="-10.8" /TU="U2388" /idTUdmin="U2389" /TUdmin=682 /isTUend="FALSE" /label="downshifts" CDS complement(2667146..2667961) /gene="menB" /locus_tag="BSU_30800" /old_locus_tag="BSU30800" /EC_number="4.1.3.36" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 6780515, 8566759, 9139683, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 6780515, 8566759, 9139683, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroxynapthoic acid synthetase" /protein_id="NP_390958.1" /db_xref="EnsemblGenomes-Gn:BSU30800" /db_xref="EnsemblGenomes-Tr:CAB15058" /db_xref="GOA:P23966" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR010198" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG10686" /db_xref="UniProtKB/Swiss-Prot:P23966" /translation="MAEWKTKRTYDEILYETYNGIAKITINRPEVHNAFTPKTVAEMI DAFADARDDQNVGVIVLAGAGDKAFCSGGDQKVRGHGGYVGDDQIPRLNVLDLQRLIR VIPKPVVAMVSGYAIGGGHVLHIVCDLTIAADNAIFGQTGPKVGSFDAGYGSGYLARI VGHKKAREIWYLCRQYNAQEALDMGLVNTVVPLEQLEEETIKWCEEMLEKSPTALRFL KAAFNADTDGLAGIQQFAGDATLLYYTTDEAKEGRDSFKEKRKPDFGQFPRFP*" /label="menB CDS" gene complement(2667146..2667961) /gene="menB" /locus_tag="BSU_30800" /old_locus_tag="BSU30800" /label="menB gene" CDS complement(2667996..2668820) /gene="menH" /locus_tag="BSU_30810" /old_locus_tag="BSU30810" /EC_number="4.2.99.20" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12454479, 23637813; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase" /protein_id="NP_390959.1" /db_xref="EnsemblGenomes-Gn:BSU30810" /db_xref="EnsemblGenomes-Tr:CAB15059" /db_xref="GOA:P23974" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR022485" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG10685" /db_xref="UniProtKB/Swiss-Prot:P23974" /translation="MGTVNITVSDGVRYAVADEGPNASEAVVCLHGFTGSKQSWTFLD EMLPDSRLIKIDCLGHGETDAPLNGKRYSTTRQVSDLAEIFDQLKLHKVKLIGYSMGG RLAYSFAMTYPERVSALVLESTTPGLKTLGERRERIMRDRKLADFILRDGLEAFVAYW ENIPLFSSQQRLAEDIRYRIRSGRLRNNKIGLANSLTGMGTGSQPSLWSRVEEIDVPV LLICGEWDEKFCAINQEVHKMLPSSRIEIVPKAGHTVHVEQPRLFGKIVSEFLTSI*" /label="menH CDS" gene complement(2667996..2668820) /gene="menH" /locus_tag="BSU_30810" /old_locus_tag="BSU30810" /label="menH gene" promotor_-10 complement(2668078..2668097) /Source="Nicolas_upshift_promotors" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2668078) /Source="Nicolas_upshifts" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2668113..2668116) /Source="Nicolas_upshift_promotors" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2668244) /Source="Nicolas_upshifts" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2668254..2668265) /Source="Nicolas_upshift_promotors" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2668280..2668286) /Source="Nicolas_upshift_promotors" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2668808..2670550) /gene="menD" /locus_tag="BSU_30820" /old_locus_tag="BSU30820" /EC_number="2.2.1.9" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 8169214, 8566759, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8169214, 8566759, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate decarboxylase and 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase" /protein_id="NP_390960.1" /db_xref="EnsemblGenomes-Gn:BSU30820" /db_xref="EnsemblGenomes-Tr:CAB15060" /db_xref="GOA:P23970" /db_xref="InterPro:IPR004433" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR032264" /db_xref="PDB:2X7J" /db_xref="SubtiList:BG10683" /db_xref="UniProtKB/Swiss-Prot:P23970" /translation="MTVNPITHYIGSFIDEFALSGITDAVVCPGSRSTPLAVLCAAHP DISVHVQIDERSAGFFALGLAKAKQRPVLLICTSGTAAANFYPAVVEAHYSRVPIIVL TADRPHELREVGAPQAINQHFLFGNFVKFFTDSALPEESPQMLRYIRTLASRAAGEAQ KRPMGPVHVNVPLREPLMPDLSDEPFGRMRTGRHVSVKTGTQSVDRESLSDVAEMLAE AEKGMIVCGELHSDADKENIIALSKALQYPILADPLSNLRNGVHDKSTVIDAYDSFLK DDELKRKLRPDVVIRFGPMPVSKPVFLWLKDDPTIQQIVIDEDGGWRDPTQASAHMIH CNASVFAEEIMAGLTAATRSSEWLEKWQFVNGRFREHLQTISSEDVSFEGNLYRILQH LVPENSSLFVGNSMPIRDVDTFFEKQDRPFRIYSNRGANGIDGVVSSAMGVCEGTKAP VTLVIGDLSFYHDLNGLLAAKKLGIPLTVILVNNDGGGIFSFLPQASEKTHFEDLFGT PTGLDFKHAAALYGGTYSCPASWDEFKTAYAPQADKPGLHLIEIKTDRQSRVQLHRDM LNEAVREVKKQWEL*" /label="menD CDS" gene complement(2668808..2670550) /gene="menD" /locus_tag="BSU_30820" /old_locus_tag="BSU30820" /label="menD gene" CDS complement(2670547..2671962) /gene="menF" /locus_tag="BSU_30830" /old_locus_tag="BSU30830" /EC_number="5.4.4.2" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6780514, 8169214, 8566759" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8169214, 8566759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="menaquinone-specific isochorismate synthase" /protein_id="NP_390961.1" /db_xref="EnsemblGenomes-Gn:BSU30830" /db_xref="EnsemblGenomes-Tr:CAB15061" /db_xref="GOA:P23973" /db_xref="InterPro:IPR004561" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR034681" /db_xref="SubtiList:BG10682" /db_xref="UniProtKB/Swiss-Prot:P23973" /translation="MVTTVQRTFRKEVLHALHKAKEVNHAVLISYSRQIESLDPLSFF NYGAKKYTGNRFFWSDPESELTIVGLGKEAVFQTNQKNSERYREVFEQWERFKKTAFH IYEEEKLQHSAVGPVLFGGFSFDPCEERGSQWDHFSEGDFFVPALMLTMTAEGPFLTV NRWVSGGEDAEAVLEGLKAFAAEFMVPDFKQEDQAVIAAAEELDKDDWLKAIETATSQ IKEKQYDKVVLARELLLTFDGPIQIEPVLKTLLDDQQTSYVFAIEQEGKTFVGASPER LIKRDGGTVMSSCLAGSIKRGVNEEDDRRIGLELLNDEKNLLEHDIVVGMIHNAFVSS CSEVEKPDGPVLYKTKSVQHLFTPIVGQLRESASIFDLIEKLHPTPALGGSPQEKAVD VIREIEPMSRGWYAAPIGWIDSQDNGEFAVAIRSGLIEGSTARLFAGCGIVEDSEPIS EYEETQIKLKPMISALGGERR*" /label="menF CDS" gene complement(2670547..2671962) /gene="menF" /locus_tag="BSU_30830" /old_locus_tag="BSU30830" /label="menF gene" S_feature complement(2671963..2672075) /Source="Nicolas_S_feature" /locus_tag="new_3153718_3153830_c" /HighExp="dia5, LBGstat, Diami, LBGtran, dia15, H2O2, G180, G150, LPhT, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1176" promotor_-10 complement(2672055..2672074) /Source="Nicolas_upshift_promotors" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="promotor_-10" upshifts complement(2672075) /Source="Nicolas_upshifts" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="upshifts" S_feature complement(2672077..2672227) /Source="Nicolas_S_feature" /locus_tag="new_3153832_3153982_c" /HighExp="S8, S7, S6, S5, BT, S4, Pyr, B36, G/S, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1177" promotor_-35 complement(2672090..2672093) /Source="Nicolas_upshift_promotors" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="promotor_-35" promotor_-35 2672188..2672194 /Source="Nicolas_upshift_promotors" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2672208..2672227) /Source="Nicolas_upshift_promotors" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2672208..2672219 /Source="Nicolas_upshift_promotors" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2672216 /Source="Nicolas_upshifts" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2672227) /Source="Nicolas_upshifts" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2672241..2672250) /Source="Nicolas_upshift_promotors" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2672252..2672971 /gene="yteA" /locus_tag="BSU_30840" /old_locus_tag="BSU30840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15496987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative regulatory protein" /protein_id="NP_390962.2" /db_xref="EnsemblGenomes-Gn:BSU30840" /db_xref="EnsemblGenomes-Tr:CAB15062" /db_xref="GOA:P42408" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR014240" /db_xref="InterPro:IPR037187" /db_xref="SubtiList:BG11200" /db_xref="UniProtKB/Swiss-Prot:P42408" /translation="MLTKEQLQHLKNELEQTKKDILNRFKDNDHFQLNSAFPYDSWGE LSAYDNHPGDQATELYEREKDIALDLHEREHLRDIEHSLKAIENGTYGICEVSGKEIP FERLEALPTATTLAEYSSQDVVSKDRPIEEETPFGQFEFDDDEEIRAPYDSEDSYQDV EKYGNSQTPQDMENPPLSYDDMTMNAEENIGNTESYENFIATDITGKEITVYQSRAHE RYEEELDEEGIMTTFGDLHAD*" /label="yteA CDS" gene 2672252..2672971 /gene="yteA" /locus_tag="BSU_30840" /old_locus_tag="BSU30840" /label="yteA gene" S_feature complement(2672322..2672979) /Source="Nicolas_S_feature" /locus_tag="new_3154077_3154734_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, G/S, Pyr, S3" /AntisenseName="yteA" /AntisenseCor="0.85796245341056299" /AntisenseRegPval="-78.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1178" downshifts 2672960 /Source="Nicolas_upshifts" /id="D1588" /incds=0 /nref=23 /ntot=40 /MaxReadThrough="0.72949" /MaxDrop="5.85132" /score="2.75726503" /energy="-10.1" /TU="NA" /idTUdmin="U2391" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" CDS complement(2672980..2673798) /gene="ytdA" /locus_tag="BSU_30850" /old_locus_tag="BSU30850" /EC_number="2.7.7.9" /function="16.8: Protect" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_390963.1" /db_xref="EnsemblGenomes-Gn:BSU30850" /db_xref="EnsemblGenomes-Tr:CAB15063" /db_xref="GOA:P42407" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11199" /db_xref="UniProtKB/Swiss-Prot:P42407" /translation="MIKKAIIPAGGFGTRNLPVTKVIPKEMFPVGSKPVIHYLVEELK ESGIEDILMVVSSHKNLIVDYFDSSLALEAFLASKNKLHLLREHPIPDIRIHYVRQPY AKGLGDAISFGKQFAGGEPFAVVLPDDLIFSANQPALGQLIEAYTKYQSSVIGLKETK TEDLHHYGVIKGEPVEKGLYRIQDIVEKPKQNPPSHFAAAGRYIFTPDIFNELEALEA DSGGEVQVTDAIKASLGACTVYGKLLEGERYDIGLQKDYLKLIYDMLKTEKNPQ*" /label="ytdA CDS" gene complement(2672980..2673798) /gene="ytdA" /locus_tag="BSU_30850" /old_locus_tag="BSU30850" /label="ytdA gene" promotor_-10 complement(2673819..2673838) /Source="Nicolas_upshift_promotors" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2673833) /Source="Nicolas_upshifts" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2673853..2673861) /Source="Nicolas_upshift_promotors" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2673899..2673907 /Source="Nicolas_upshift_promotors" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2673920..2673939 /Source="Nicolas_upshift_promotors" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2673921 /Source="Nicolas_upshifts" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="upshifts" CDS 2673970..2675256 /gene="ytcA" /locus_tag="BSU_30860" /old_locus_tag="BSU30860" /EC_number="1.1.1.22" /function="16.14: Store" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UDP-glucose dehydrogenase" /protein_id="NP_390964.1" /db_xref="EnsemblGenomes-Gn:BSU30860" /db_xref="EnsemblGenomes-Tr:CAB15064" /db_xref="GOA:O34862" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13828" /db_xref="UniProtKB/Swiss-Prot:O34862" /translation="MKICVVGAGYVGLTLSAALASIGHDMICTDKDVKKIGQLKKGVI PFYEPGLSDAILRCGNLSFSSEVKSSMEECPVIFIAVGTPPRSDGSADTKALQSVIGD LSEAIRSYKTIITKSTVPPGTNENIAKQLIASGVSKNLFNIVSNPEFLREGNALYDML HPDKTVIGVQEEDHVSAAIVKSIYKHIDTPFIVTSLAGAELIKYANNFFLAAKISFIN EMARICEAYQSDISDISRAIGLDPRIGKHFLQAGIGYGGSCFPKDLQALQFAAQEKNT ETFLLRAVQHINDTQLGLYIKKIQSFFETLQGKKAAVLGISFKPNTDDIRNSQAVRLM ERLAELGCDVHAYDPEAVLPEHLRQHVTQHSQAFDAIEESDFLFLATEWSEFLAFDWK KAADIMKGRLVIDGRNVLKKELIEACGLICTGVGRP*" /label="ytcA CDS" gene 2673970..2675256 /gene="ytcA" /locus_tag="BSU_30860" /old_locus_tag="BSU30860" /label="ytcA gene" CDS 2675253..2676203 /gene="ytcB" /locus_tag="BSU_30870" /old_locus_tag="BSU30870" /EC_number="5.1.3.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UDP-glucose epimerase" /protein_id="NP_390965.1" /db_xref="EnsemblGenomes-Gn:BSU30870" /db_xref="EnsemblGenomes-Tr:CAB15065" /db_xref="GOA:O34886" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13829" /db_xref="UniProtKB/Swiss-Prot:O34886" /translation="MKILVTGAAGFIGSHLCEELLKDKKHNVIGIDDFIGPTPFSLKL KNLKNLLPEKRFTFIKENLLTADLASLLEGVDVIFHLAAIPGVRSSWGNHFHPYAAHN IQALQRLLEACREHSIQTFVFASTSSVYGEKQGKVSENTSLSPLSPYGVTKLTGEKLC HVYKQSFGIPIVILRFFTVYGPRQRPDMAFHRLIKQHLQQKPLTIFGDGQQSRDFTYI SDCVKGITAVLGKPHLIGETVNIGGAERASVLKVVSLIEDISGRKATLHFSDKIAGEP SNTWADISKAKQLLHYDPATSLKDGLTNEIAYLSSLYQGE*" /label="ytcB CDS" gene 2675253..2676203 /gene="ytcB" /locus_tag="BSU_30870" /old_locus_tag="BSU30870" /label="ytcB gene" CDS 2676206..2677429 /gene="ytcC" /locus_tag="BSU_30880" /old_locus_tag="BSU30880" /EC_number="2.4.1.-" /function="16.14: Store" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glucosyltransferase" /protein_id="NP_390966.1" /db_xref="EnsemblGenomes-Gn:BSU30880" /db_xref="EnsemblGenomes-Tr:CAB15066" /db_xref="GOA:O34413" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG13830" /db_xref="UniProtKB/Swiss-Prot:O34413" /translation="MKLAFICTEKLPAPAVRGGAIQMMIDGVTPYFSSRYDLTIFSIE DPSLPKRETKDGVHYIHLPKEHYREAVAEELRASSFDLIHVFNRPLNVSLYKKASPNS KIVLSLHNEMFSEKKMTFAQGKEVLDNVSMITTVSEFIKQTVIERFPEAEDITKVVYS GVDLNSYPPVWTMKGSAVRKTYRKKYGIEDKKVILFAGRLSPTKGPHLLIHSMRRILQ QHPDAVLVIAGGKWFSDDSENQYVTYLRTLALPYRDHIIFTKFIPADDIPNLFLMADV FVCSSQWNEPLARVNYEAMAAGTPLITTNRGGNGEVVKHEVTGLVIDSYNKPSSFAKA IDRAFTDQELMNKMTKNARKHVEALFTFTHAAKRLNTVYQSVLTPKNKQFPPPFLTQN FDLSSINQLFVKAKT*" /label="ytcC CDS" gene 2676206..2677429 /gene="ytcC" /locus_tag="BSU_30880" /old_locus_tag="BSU30880" /label="ytcC gene" downshifts complement(2677353) /Source="Nicolas_upshifts" /id="D1589" /incds=1 /nref=1 /ntot=10 /MaxReadThrough="1.32025" /MaxDrop="3.47267" /score="-3.65321449" /energy="-3.1" /TU="NA" /idTUdmin="U2395" /TUdmin=66 /isTUend="FALSE" /label="downshifts" S_feature 2677430..2677997 /Source="Nicolas_S_feature" /locus_tag="new_3159185_3159752" /HighExp="S8, S7, BT, S6, C30, Pyr, S5, G/S, C90, Glucon" /AntisenseName="ytxO" /AntisenseCor="0.86121563743373297" /AntisenseRegPval="-79.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S1179" CDS complement(2677503..2677934) /gene="cotOO" /locus_tag="BSU_30890" /old_locus_tag="BSU30890" /experiment="publication(s) with functional evidences, PMID:19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19933362; Product type s: structure" /codon_start=1 /transl_table=11 /product="outer spore coat protein" /protein_id="NP_390967.1" /db_xref="EnsemblGenomes-Gn:BSU30890" /db_xref="EnsemblGenomes-Tr:CAB15067" /db_xref="SubtiList:BG11382" /db_xref="UniProtKB/Swiss-Prot:P46916" /translation="MRSSRQKASISKLDLDQFVFTPPGPMGWQAHDSISAEKEEEEKH LDVGSIRELPHINAPKEYQKETKEKETDRKIVDDEEETKFETTLEPEEERDSKRSAPP YEEEDEDEEPDLAEEAKVEIIILPSESKPAPWFSQTVKRKA*" /label="cotOO CDS" gene complement(2677503..2677934) /gene="cotOO" /locus_tag="BSU_30890" /old_locus_tag="BSU30890" /label="cotOO gene" downshifts complement(2677529) /Source="Nicolas_upshifts" /id="D1590" /incds=0 /nref=11 /ntot=36 /MaxReadThrough="3.07378" /MaxDrop="4.8822" /score="9.30990044" /energy="-8.3" /TU="U2395" /idTUdmin="U2395" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" CDS complement(2677936..2678991) /gene="cotS" /locus_tag="BSU_30900" /old_locus_tag="BSU30900" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7545510, 9603889, 10234840, 11737650, 14702409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7545510, 9603889, 10234840, 11737650, 14702409; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390968.1" /db_xref="EnsemblGenomes-Gn:BSU30900" /db_xref="EnsemblGenomes-Tr:CAB15068" /db_xref="GOA:P46914" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014255" /db_xref="SubtiList:BG11380" /db_xref="UniProtKB/Swiss-Prot:P46914" /translation="MYQKEHEEQIVSEILSYYPFHIDHVALKSNKSGRKIWEVETDHG PKLLKEAQMKPERMLFITQAHAHLQEKGLPIAPIHQTKNGGSCLGTDQVSYSLYDKVT GKEMIYYDAEQMKKVMSFAGHFHHASKGYVCTDESKKRSRLGKWHKLYRWKLQELEGN MQIAASYPDDVFSQTFLKHADKMLARGKEALRALDDSEYETWTKETLEHGGFCFQDFT LARLTEIEGEPFLKELHSITYDLPSRDLRILLNKVMVKLSVWDTDFMVALLAAYDAVY PLTEKQYEVLWIDLAFPHLFCAIGHKYYLKQKKTWSDEKYNWALQNMISVEESKDSFL DKLPELYKKIKAYREAN*" /label="cotS CDS" gene complement(2677936..2678991) /gene="cotS" /locus_tag="BSU_30900" /old_locus_tag="BSU30900" /label="cotS gene" CDS complement(2679006..2680139) /gene="cotSA" /locus_tag="BSU_30910" /old_locus_tag="BSU30910" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9603889, 10234840, 11737650" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9603889, 10234840, 11737650; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390969.1" /db_xref="EnsemblGenomes-Gn:BSU30910" /db_xref="EnsemblGenomes-Tr:CAB15069" /db_xref="GOA:P46915" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11381" /db_xref="UniProtKB/Swiss-Prot:P46915" /translation="MKIALIATEKLPVPSVRGGAIQIYLEAVAPLIAKKHEVTVFSIK DPNLADREKVDGVHYVHLDEDRYEEAVGAELKKSRFDLVHVCNRPSWVPKLKKQAPDA VFILSVHNEMFAYDKISQAEGEICIDSVAQIVTVSDYIGQTITSRFPSARSKTKTVYS GVDLKTYHPRWTNEGQRAREEMRSELGLHGKKIVLFVGRLSKVKGPHILLQALPDIIE EHPDVMMVFIGSKWFGDNELNNYVKHLHTLGAMQKDHVTFIQFVKPKDIPRLYTMSDV FVCSSQWQEPLARVHYEAMAAGLPIITSNRGGNPEVIEEGKNGYIIHDFENPKQYAER INDLLSSSEKRERLGKYSRREAESNFGWQRVAENLLSVYEKNR*" /label="cotSA CDS" gene complement(2679006..2680139) /gene="cotSA" /locus_tag="BSU_30910" /old_locus_tag="BSU30910" /label="cotSA gene" promotor_-10 complement(2680172..2680191) /Source="Nicolas_upshift_promotors" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2680191) /Source="Nicolas_upshifts" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2680204..2680213) /Source="Nicolas_upshift_promotors" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2680277..2680286 /Source="Nicolas_upshift_promotors" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2680300..2680319 /Source="Nicolas_upshift_promotors" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2680302 /Source="Nicolas_upshifts" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="upshifts" CDS 2680329..2681402 /gene="cotI" /locus_tag="BSU_30920" /old_locus_tag="BSU30920" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12562816, 20077512" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 20077512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat kinase" /protein_id="NP_390970.1" /db_xref="EnsemblGenomes-Gn:BSU30920" /db_xref="EnsemblGenomes-Tr:CAB15070" /db_xref="GOA:O34656" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014255" /db_xref="PDB:2Q83" /db_xref="SubtiList:BG13821" /db_xref="UniProtKB/Swiss-Prot:O34656" /translation="MCPLMAENHEVIEEGNSSELPLSAEDAKKLTELAENVLQGWDVQ AEKIDVIQGNQMALVWKVHTDSGAVCLKRIHRPEKKALFSIFAQDYLAKKGMNVPGIL PNKKGSLYSKHGSFLFVVYDWIEGRPFELTVKQDLEFIMKGLADFHTASVGYQPPNGV PIFTKLGRWPNHYTKRCKQMETWKLMAEAEKEDPFSQLYLQEIDGFIEDGLRIKDRLL QSTYVPWTEQLKKSPNLCHQDYGTGNTLLGENEQIWVIDLDTVSFDLPIRDLRKMIIP LLDTTGVWDDETFNVMLNAYESRAPLTEEQKQVMFIDMLFPYELYDVIREKYVRKSAL PKEELESAFEYERIKANALRQLI*" /label="cotI CDS" gene 2680329..2681402 /gene="cotI" /locus_tag="BSU_30920" /old_locus_tag="BSU30920" /label="cotI gene" promotor_-35 2680626..2680632 /Source="Nicolas_upshift_promotors" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2680643 /Source="Nicolas_upshifts" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2680646..2680657 /Source="Nicolas_upshift_promotors" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 2681391 /Source="Nicolas_upshifts" /id="D1591" /incds=0 /nref=16 /ntot=35 /MaxReadThrough="3.14769" /MaxDrop="5.1897" /score="-2.47616606" /energy="-10.3" /TU="U2396,U2397" /idTUdmin="U2396" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-35 2681429..2681435 /Source="Nicolas_upshift_promotors" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2681450 /Source="Nicolas_upshifts" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2681451..2681469 /Source="Nicolas_upshift_promotors" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2681482..2681949 /gene="ytaB" /locus_tag="BSU_30930" /old_locus_tag="BSU30930" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717291, 15849754, 16850406; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative receptor" /protein_id="NP_390971.1" /db_xref="EnsemblGenomes-Gn:BSU30930" /db_xref="EnsemblGenomes-Tr:CAB15071" /db_xref="GOA:O34694" /db_xref="InterPro:IPR004307" /db_xref="SubtiList:BG13822" /db_xref="UniProtKB/Swiss-Prot:O34694" /translation="MKKIVGALAVFVITYALFSAAGYLFPVDQEWYNSLKKPDWTPSG TAIGIIWAILFALISLSAAIVYAAFSFKGAKSFWFTLLINYVLNQAFSYFQFTQKNLL AASLDCLLVAITAIVLLIIAKKYSRAASYLLLPYFLWSAFATFLSFTINSMNL*" /label="ytaB CDS" gene 2681482..2681949 /gene="ytaB" /locus_tag="BSU_30930" /old_locus_tag="BSU30930" /label="ytaB gene" downshifts 2681921 /Source="Nicolas_upshifts" /id="D1592" /incds=0 /nref=43 /ntot=123 /MaxReadThrough="2.47485" /MaxDrop="5.7907" /score="9.10214462" /energy="-10.1" /TU="NA" /idTUdmin="U2396" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(2681980..2684376) /gene="glgP" /locus_tag="BSU_30940" /old_locus_tag="BSU30940" /EC_number="2.4.1.1" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8145641, 9244254, 15272305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycogen phosphorylase" /protein_id="NP_390972.1" /db_xref="EnsemblGenomes-Gn:BSU30940" /db_xref="EnsemblGenomes-Tr:CAB15072" /db_xref="GOA:P39123" /db_xref="InterPro:IPR000811" /db_xref="InterPro:IPR011833" /db_xref="InterPro:IPR035090" /db_xref="SubtiList:BG10911" /db_xref="UniProtKB/Swiss-Prot:P39123" /translation="MFSSKERFADLFLKRLEMTCGKSFKDSAKLDQYKTLGNMVREYI SADWIETNEKSRSNSGKQTYYLSIEFLLGQLLEQNLMNLGVRDVVEAGLKEIGINLEE ILQIENDAGLGNGGLGRLAACFLDSLASLNLPGHGMGIRYKHGLFEQKIVDGHQVELP EQWLKNGNVWEVRNADQAVDVPFWGEVHMTEKSGRLHFRHEQATIVTAVPYDIPIIGY ETGTVNTLRLWNAEPYAHYHGGNILSYKRETEAVSEFLYPDDTHDEGKILRLKQQYFL VCASLKSIVNNYRKTHKSLSGLHKKVSIHINDTHPALAVPELMRILLDEENMSWEEAW HITVHTISYTNHTTLSEALEKWPIHLFKPLLPRMYMIIEEINERFCRAVWEKYPGDWK RIENMAITAHGVVKMAHLAIVGSYSVNGVAKIHSDILKEREMRDFHLLFPNRFNNKTN GIAHRRWLLKANPGLSAIITEAIGDEWVKQPESLIRLEPYATDPAFIEQFQNNKSKKK QELADLIFCTAGVVVNPESIFDVQVKRLHAYKRQLLNVLHIMYLYNRLKEDSGFSIYP QTFIFGAKASPSYYYAKKIIKLIHSVAEKVNYDPAVKQLIKVVFLENYRVSMAERIFP ASDVSEQISTASKEASGTGNMKFMMNGALTIGTHDGANIEILERVGPDCIYTFGLKAD EVLSYQENGGYRSREYYQHDRRIRQVADQLINGFFEGEADEFESIFDSLLPHNDEYFV LKDFSSYADAQERIQADYRERRKWSEHSIVNIAHSGYFSSDRTIREYAKDIWGIKPMM *" /label="glgP CDS" gene complement(2681980..2684376) /gene="glgP" /locus_tag="BSU_30940" /old_locus_tag="BSU30940" /label="glgP gene" downshifts complement(2681995) /Source="Nicolas_upshifts" /id="D1593" /incds=0 /nref=6 /ntot=43 /MaxReadThrough="2.31076" /MaxDrop="4.39135" /score="34.694666" /energy="-10.1" /TU="NA" /idTUdmin="U2399" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2684363..2685817) /gene="glgA" /locus_tag="BSU_30950" /old_locus_tag="BSU30950" /EC_number="2.4.1.21" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:8145641, 15272305" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8145641, 15272305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycogen (starch) synthase" /protein_id="NP_390973.1" /db_xref="EnsemblGenomes-Gn:BSU30950" /db_xref="EnsemblGenomes-Tr:CAB15073" /db_xref="GOA:P39125" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR011835" /db_xref="InterPro:IPR013534" /db_xref="SubtiList:BG10910" /db_xref="UniProtKB/Swiss-Prot:P39125" /translation="MKILFAVSECTPFVKSGGLADVAGALPKALARLGNEVAVMLPKY SQIPEPWKKRMKKQAECTVAVGWRQQYCGIEHMAENDVNYYFIDNEYYFNRDSLYGHY DDGERFAFFSRAVLEAAKVVNVQADIVHTHDWHTAMVNYLLKEEYRKHPFYERMKSVL TIHNLQFQGIFPPDVTHDLLGLEMDHFHYERLECNGFVNFMKAGIIAADHVTTVSPTY RNEIMTPYYGEQLEQVLQYREDDVTGILNGIDDTFYQPKSDPYIEAQYDSGDLACKLE NKTKLQQRMGLPEKNDIPLISMVTRLTKQKGLDLVRRIMHELLEEQDIQLVVLGTGER EFEDYFRYAEFAFHEKCRAYIGFDEPLAHQIYAGSDMFLMPSKFEPCGLGQLIALQYG AIPIVRETGGLYDTVRAYQEEEGTGNGFTFSAFNAHDLKFTIERALSFYCQQDVWKSI VKTAMNADYSWGKSAKEYQRIFEQVTRSGRDVLE*" /label="glgA CDS" gene complement(2684363..2685817) /gene="glgA" /locus_tag="BSU_30950" /old_locus_tag="BSU30950" /label="glgA gene" CDS complement(2685814..2686845) /gene="glgD" /locus_tag="BSU_30960" /old_locus_tag="BSU30960" /EC_number="2.7.7.27" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8145641, 9244254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate adenylyltransferase (ADP-glucose pyrophosphorylase) beta subunit" /protein_id="NP_390974.1" /db_xref="EnsemblGenomes-Gn:BSU30960" /db_xref="EnsemblGenomes-Tr:CAB15074" /db_xref="GOA:P39124" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR011832" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10909" /db_xref="UniProtKB/Swiss-Prot:P39124" /translation="MFNNQMLGVIDETTYKHSLQDLTAQRSLGAIPFAGRYRLIDFML SNMVNADIRSVAIFPKYRYRSLMDHLGAGKEWDLHRKKDGLFFFPSPHLHHEYDEFGS FRQFSDHLDYFHRSTQQYAVISNSHTVCNIQFQYVLKRHQEVGCDVTEVFQDGQSLQI YIMSTTLLKDLIYGHSEKGYKTIQEAVEKESSALTICPYEYSGYAAVIDSVEKYYTHS MELIQPRFWQQVFLPQQPIYTKVKDEPPTKYGKHSTVKNSLVANGCVLEGEVENCILF RAVHVGKGTKLKNCIIMQKTQIGEDCLLEQVISDKDVKIGKATEAAGTAEQPLVLRKG LVQGELMNS*" /label="glgD CDS" gene complement(2685814..2686845) /gene="glgD" /locus_tag="BSU_30960" /old_locus_tag="BSU30960" /label="glgD gene" CDS complement(2686869..2688011) /gene="glgC" /locus_tag="BSU_30970" /old_locus_tag="BSU30970" /EC_number="2.7.7.27" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8145641, 9244254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate adenylyltransferase (ADP-glucose pyrophosphorylase) subunit alpha" /protein_id="NP_390975.1" /db_xref="EnsemblGenomes-Gn:BSU30970" /db_xref="EnsemblGenomes-Tr:CAB15075" /db_xref="GOA:P39122" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005836" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR011831" /db_xref="InterPro:IPR023049" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10908" /db_xref="UniProtKB/Swiss-Prot:P39122" /translation="MKKQCVAMLLAGGKGSRLSGLTKNMAKPAVSFGGKYRIIDFTLS NCSNSGIDTVGILTQYQPLELNSYIGIGSAWDLDRYNGGVTVLPPYAESSEVKWYKGT ASSIYENLNYLNQYDPEYVLILSGDHIYKMDYGKMLDYHIEKKADVTISVIEVGWEEA SRFGIMKANPDGTITHFDEKPKFPKSNLASMGIYIFNWPLLKQYLEMDDQNPYSSHDF GKDIIPLLLEEKKKLSAYPFKGYWKDVGTVQSLWEANMDLLKEDSELKLFERKWKIYS VNPNQPPQFISSDAQVQDSLVNEGCVVYGNVSHSVLFQGVTVGKHTTVTSSVIMPDVT IGEHVVIENAIVPNGMVLPDGAVIRSEKDIEEVLLVSEEFVEKELI*" /label="glgC CDS" gene complement(2686869..2688011) /gene="glgC" /locus_tag="BSU_30970" /old_locus_tag="BSU30970" /label="glgC gene" CDS complement(2688008..2689891) /gene="glgB" /locus_tag="BSU_30980" /old_locus_tag="BSU30980" /EC_number="2.4.1.18" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1296817, 15272305, 8145641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,4-alpha-glucan branching enzyme" /protein_id="NP_390976.1" /db_xref="EnsemblGenomes-Gn:BSU30980" /db_xref="EnsemblGenomes-Tr:CAB15076" /db_xref="GOA:P39118" /db_xref="InterPro:IPR004193" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR006048" /db_xref="InterPro:IPR006407" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG10907" /db_xref="UniProtKB/Swiss-Prot:P39118" /translation="MAAASPTAHDVYLFHEGSLFKSYQLFGSHYRELNGKSGYEFCVW APHASEVRVAGDFNSWSGEEHVMHRVNDNGIWTLFIPGIGEKERYKYEIVTNNGEIRL KADPYAIYSEVRPNTASLTYDLEGYSWQDQKWQKKQKAKTLYEKPVFIYELHLGSWKK HSDGRHYSYKELSQTLIPYIKKHGFTHIELLPVYEHPYDRSWGYQGTGYYSPTSRFGP PHDLMKFVDECHQQNIGVILDWVPGHFCKDAHGLYMFDGEPLYEYKEERDRENWLWGT ANFDLGKPEVHSFLISNALYWAEFYHIDGFRVDAVANILYWPNQDERHTNPYAVDFLK KLNQTMREAYPHVMMIAEDSTEWPQVTGAVEEGGLGFHYKWNMGWMNDVLKYMETPPE ERRHCHQLISFSLLYAFSEHFVLPFSHDEVVYGKKSLLNKMPGDYWQKFAQYRLLLGY MTVHPGKKLIFMGSEFAQFDEWKDTEQLDWFLDSFPMHQKASVFTQDLLRFYQKSKIL YEHDHRAQSFEWIDVHNDEQSIFSFIRYGQKHGEALVIICNFTPVVYHQYDVGVPFFT QYIEVLNSDSETYGGSGQINKKPLSAKKGALHHKPCYITMTIPPYGISILRAVKKRGE IKR*" /label="glgB CDS" gene complement(2688008..2689891) /gene="glgB" /locus_tag="BSU_30980" /old_locus_tag="BSU30980" /label="glgB gene" S_feature 2688717..2690136 /Source="Nicolas_S_feature" /locus_tag="new_3170472_3171891" /HighExp="S8, S7, S6, C30, BT, Pyr, G/S, S2, C90, BC" /AntisenseName="glgB" /AntisenseCor="0.59299722159013002" /AntisenseRegPval="-26.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1180" promotor_-10 complement(2689923..2689938) /Source="Nicolas_upshift_promotors" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2689936) /Source="Nicolas_upshifts" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2689953..2689958) /Source="Nicolas_upshift_promotors" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2690003) /Source="Nicolas_upshifts" /id="D1594" /incds=0 /nref=2 /ntot=46 /MaxReadThrough="1.66182" /MaxDrop="3.12741" /score="36.0363304" /energy="-9.2" /TU="NA" /idTUdmin="U2401" /TUdmin=198 /isTUend="FALSE" /label="downshifts" tRNA complement(2690124..2690195) /gene="trnB-Glu" /locus_tag="BSU_tRNA_72" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Glu tRNA" gene complement(2690124..2690195) /gene="trnB-Glu" /locus_tag="BSU_tRNA_72" /label="trnB-Glu gene" tRNA complement(2690221..2690311) /gene="trnB-Ser2" /locus_tag="BSU_tRNA_71" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ser2 tRNA" gene complement(2690221..2690311) /gene="trnB-Ser2" /locus_tag="BSU_tRNA_71" /label="trnB-Ser2 gene" tRNA complement(2690315..2690389) /gene="trnB-Asn" /locus_tag="BSU_tRNA_70" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Asn tRNA" gene complement(2690315..2690389) /gene="trnB-Asn" /locus_tag="BSU_tRNA_70" /label="trnB-Asn gene" tRNA complement(2690400..2690476) /gene="trnB-Ile2" /locus_tag="BSU_tRNA_69" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ile2 tRNA" gene complement(2690400..2690476) /gene="trnB-Ile2" /locus_tag="BSU_tRNA_69" /label="trnB-Ile2 gene" tRNA complement(2690492..2690565) /gene="trnB-Gly2" /locus_tag="BSU_tRNA_68" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Gly2 tRNA" gene complement(2690492..2690565) /gene="trnB-Gly2" /locus_tag="BSU_tRNA_68" /label="trnB-Gly2 gene" tRNA complement(2690576..2690651) /gene="trnB-His" /locus_tag="BSU_tRNA_67" /product="tRNA-His" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-His tRNA" gene complement(2690576..2690651) /gene="trnB-His" /locus_tag="BSU_tRNA_67" /label="trnB-His gene" tRNA complement(2690669..2690744) /gene="trnB-Phe" /locus_tag="BSU_tRNA_66" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Phe tRNA" gene complement(2690669..2690744) /gene="trnB-Phe" /locus_tag="BSU_tRNA_66" /label="trnB-Phe gene" tRNA complement(2690757..2690833) /gene="trnB-Asp" /locus_tag="BSU_tRNA_65" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Asp tRNA" gene complement(2690757..2690833) /gene="trnB-Asp" /locus_tag="BSU_tRNA_65" /label="trnB-Asp gene" tRNA complement(2690845..2690921) /gene="trnB-Met2" /locus_tag="BSU_tRNA_64" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Met2 tRNA" gene complement(2690845..2690921) /gene="trnB-Met2" /locus_tag="BSU_tRNA_64" /label="trnB-Met2 gene" tRNA complement(2690939..2691031) /gene="trnB-Ser1" /locus_tag="BSU_tRNA_63" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ser1 tRNA" gene complement(2690939..2691031) /gene="trnB-Ser1" /locus_tag="BSU_tRNA_63" /label="trnB-Ser1 gene" tRNA complement(2691038..2691114) /gene="trnB-Met3" /locus_tag="BSU_tRNA_62" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Met3 tRNA" gene complement(2691038..2691114) /gene="trnB-Met3" /locus_tag="BSU_tRNA_62" /label="trnB-Met3 gene" tRNA complement(2691117..2691193) /gene="trnB-Met1" /locus_tag="BSU_tRNA_61" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Met1 tRNA" gene complement(2691117..2691193) /gene="trnB-Met1" /locus_tag="BSU_tRNA_61" /label="trnB-Met1 gene" tRNA complement(2691213..2691285) /gene="trnB-Ala" /locus_tag="BSU_tRNA_60" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ala tRNA" gene complement(2691213..2691285) /gene="trnB-Ala" /locus_tag="BSU_tRNA_60" /label="trnB-Ala gene" tRNA complement(2691291..2691367) /gene="trnB-Pro" /locus_tag="BSU_tRNA_59" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Pro tRNA" gene complement(2691291..2691367) /gene="trnB-Pro" /locus_tag="BSU_tRNA_59" /label="trnB-Pro gene" tRNA complement(2691383..2691459) /gene="trnB-Arg" /locus_tag="BSU_tRNA_58" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Arg tRNA" gene complement(2691383..2691459) /gene="trnB-Arg" /locus_tag="BSU_tRNA_58" /label="trnB-Arg gene" tRNA complement(2691469..2691554) /gene="trnB-Leu2" /locus_tag="BSU_tRNA_57" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Leu2 tRNA" gene complement(2691469..2691554) /gene="trnB-Leu2" /locus_tag="BSU_tRNA_57" /label="trnB-Leu2 gene" tRNA complement(2691569..2691643) /gene="trnB-Gly1" /locus_tag="BSU_tRNA_56" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Gly1 tRNA" gene complement(2691569..2691643) /gene="trnB-Gly1" /locus_tag="BSU_tRNA_56" /label="trnB-Gly1 gene" tRNA complement(2691649..2691735) /gene="trnB-Leu1" /locus_tag="BSU_tRNA_55" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Leu1 tRNA" gene complement(2691649..2691735) /gene="trnB-Leu1" /locus_tag="BSU_tRNA_55" /label="trnB-Leu1 gene" tRNA complement(2691746..2691821) /gene="trnB-Lys" /locus_tag="BSU_tRNA_54" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Lys tRNA" gene complement(2691746..2691821) /gene="trnB-Lys" /locus_tag="BSU_tRNA_54" /label="trnB-Lys gene" tRNA complement(2691859..2691934) /gene="trnB-Thr" /locus_tag="BSU_tRNA_53" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Thr tRNA" gene complement(2691859..2691934) /gene="trnB-Thr" /locus_tag="BSU_tRNA_53" /label="trnB-Thr gene" tRNA complement(2691967..2692042) /gene="trnB-Val" /locus_tag="BSU_tRNA_52" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Val tRNA" gene complement(2691967..2692042) /gene="trnB-Val" /locus_tag="BSU_tRNA_52" /label="trnB-Val gene" rRNA complement(2692063..2692180) /gene="rrnB-5S" /locus_tag="BSU_rRNA_21" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnB-5S rRNA" gene complement(2692063..2692180) /gene="rrnB-5S" /locus_tag="BSU_rRNA_21" /label="rrnB-5S gene" rRNA complement(2692236..2695163) /gene="rrnB-23S" /locus_tag="BSU_rRNA_20" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnB-23S rRNA" gene complement(2692236..2695163) /gene="rrnB-23S" /locus_tag="BSU_rRNA_20" /label="rrnB-23S gene" rRNA complement(2695331..2696885) /gene="rrnB-16S" /locus_tag="BSU_rRNA_19" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnB-16S rRNA" gene complement(2695331..2696885) /gene="rrnB-16S" /locus_tag="BSU_rRNA_19" /label="rrnB-16S gene" Polymorphism join(2696687,2696689) /Source="geneious" /ID="SNP_BsDelta6_3178443_3178443" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="T -> C" /Codon_Change /Coverage=95 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="3.5e-102" /Variant_Raw_Frequency=94 /comment="rrnB-16S rRNA" /modified_by="User" / /label="Polymorphism_Delta6" S_feature complement(2696886..2697177) /Source="Nicolas_S_feature" /locus_tag="new_3178641_3178932_c" /HighExp="Diami, LPhT, C30, LBGstat, HPh, GM 120, Oxctl, Paraq, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40784100000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S1181" misc_feature 2697013..2697021 /Source="Nicolas_upshift_promotors" /id="U2400" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.413586413586414" /psig="0.320679320679321" /xcortree=710 /SigmaFactorBS="tgactacgcacatcgcagtgcgatttttaaaaactgaattaa caggtacgttttGTCTTGTTTagttttcaaagatcatttcgttacttctcaatgaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2697019 /Source="Nicolas_upshifts" /id="U2400" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.413586413586414" /psig="0.320679320679321" /xcortree=710 /SigmaFactorBS="tgactacgcacatcgcagtgcgatttttaaaaactgaattaa caggtacgttttGTCTTGTTTagttttcaaagatcatttcgttacttctcaatgaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2697129 /Source="Nicolas_upshifts" /id="D1595" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="2.91899" /MaxDrop="4.63941" /score="-0.368124787" /energy="-10.2" /TU="U2400" /idTUdmin="U2400" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2697150..2697169) /Source="Nicolas_upshift_promotors" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2697177) /Source="Nicolas_upshifts" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2697179..2698145) /Source="Nicolas_S_feature" /locus_tag="new_3178934_3179900_c" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, T0.0H, T3.0H, T-0.40H, S8, T3.30H" /AntisenseName="thiT" /AntisenseCor="-0.219467435413819" /AntisenseRegPval="-3.5" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1182" promotor_-35 complement(2697183..2697190) /Source="Nicolas_upshift_promotors" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2697302..2697305 /Source="Nicolas_upshift_promotors" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2697317 /Source="Nicolas_upshifts" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2697320..2697339 /Source="Nicolas_upshift_promotors" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 2697350..2697451 /gene="tswC" /locus_tag="BSU_misc_RNA_51" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswC RNA" gene 2697350..2697451 /gene="tswC" /locus_tag="BSU_misc_RNA_51" /label="tswC gene" downshifts 2697450 /Source="Nicolas_upshifts" /id="D1596" /incds=0 /nref=47 /ntot=135 /MaxReadThrough="5.85975" /MaxDrop="7.03111" /score="-0.368124787" /energy="-10.2" /TU="U2402" /idTUdmin="U2400" /TUdmin=299 /isTUend="FALSE" /label="downshifts" CDS 2697551..2698129 /gene="thiT" /locus_tag="BSU_30990" /old_locus_tag="BSU30990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 19181806" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 19181806; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamin permease" /protein_id="NP_390977.1" /db_xref="EnsemblGenomes-Gn:BSU30990" /db_xref="EnsemblGenomes-Tr:CAB15077" /db_xref="GOA:O32074" /db_xref="InterPro:IPR012651" /db_xref="SubtiList:BG13949" /db_xref="UniProtKB/Swiss-Prot:O32074" /translation="MNQSKQLVRLIEIAIMTAAAVILDIVSGMFLSMPQGGSVSIMMI PIFLISFRWGVKAGLTTGLLTGLVQIAIGNLFAQHPVQLLLDYIVAFAAIGISGCFAS SVRKAAVSKTKGKLIVSVVSAVFIGSLLRYAAHVISGAVFFGSFAPKGTPVWIYSLTY NATYMVPSFIICAIVLCLLFMTAPRLLKSDKA*" /label="thiT CDS" gene 2697551..2698129 /gene="thiT" /locus_tag="BSU_30990" /old_locus_tag="BSU30990" /label="thiT gene" downshifts 2698119 /Source="Nicolas_upshifts" /id="D1597" /incds=0 /nref=129 /ntot=206 /MaxReadThrough="1.91553" /MaxDrop="5.49387" /score="35.5376279" /energy="-19.5" /TU="NA" /idTUdmin="U2402" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2698171..2698692) /gene="yuaI" /locus_tag="BSU_31000" /old_locus_tag="BSU31000" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390978.1" /db_xref="EnsemblGenomes-Gn:BSU31000" /db_xref="EnsemblGenomes-Tr:CAB15078" /db_xref="GOA:O32075" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13948" /db_xref="UniProtKB/Swiss-Prot:O32075" /translation="MVTVREAKLEDIKDIAKVHVDSWRTTYHEIIPIDYLNSLNYKEF EDKWKSRSLKGVFVAQDEKGSVFGFASFGPIRSEQEGYDGELYAIYLLEERQRQGAGR ALLAKGAEFLLQHGFSSMFVWVIEQNPSIIFYQAYSPERVAEDNFEIAGVRLKEVGLG WPDLSALKTLLNR*" /label="yuaI CDS" gene complement(2698171..2698692) /gene="yuaI" /locus_tag="BSU_31000" /old_locus_tag="BSU31000" /label="yuaI gene" downshifts complement(2698189) /Source="Nicolas_upshifts" /id="D1598" /incds=0 /nref=8 /ntot=143 /MaxReadThrough="6.18352" /MaxDrop="5.43101" /score="13.1646679" /energy="-19.6" /TU="U2403" /idTUdmin="U2405" /TUdmin=6 /isTUend="TRUE" /label="downshifts" downshifts complement(2698261) /Source="Nicolas_upshifts" /id="D1599" /incds=1 /nref=8 /ntot=208 /MaxReadThrough="8.2849" /MaxDrop="3.3545" /score="13.1646679" /energy="-19.6" /TU="U2403,U2405" /idTUdmin="U2405" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2698710..2700239) /gene="floT" /locus_tag="BSU_31010" /old_locus_tag="BSU31010" /experiment="publication(s) with functional evidences, PMID:9153235, 9987136, 12533473, 17482313, 19383680, 25635948, 26297017, 28681845" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9153235, 9987136, 12533473, 17482313, 19383680, 25635948, 26297017, 28681845; Product type s: structure" /codon_start=1 /transl_table=11 /product="flotillin lipid rafts scaffold protein" /protein_id="NP_390979.1" /db_xref="EnsemblGenomes-Gn:BSU31010" /db_xref="EnsemblGenomes-Tr:CAB15079" /db_xref="GOA:O32076" /db_xref="InterPro:IPR001107" /db_xref="InterPro:IPR027705" /db_xref="InterPro:IPR031905" /db_xref="InterPro:IPR036013" /db_xref="SubtiList:BG13947" /db_xref="UniProtKB/Swiss-Prot:O32076" /translation="MTMPIIMIIGVVFFLLIALIAVFITKYRTAGPDEALIVTGSYLG NKNVHVDEGGNRIKIVRGGGTFVLPVFQQAEPLSLLSSKLDVSTPEVYTEQGVPVMAD GTAIIKIGGSIGEIATAAEQFLGKSKDDREQEAREVLEGHLRSILGSMTVEEIYKNRE KFSQEVQRVASQDLAKMGLVIVSFTIKDVRDKNGYLESLGKPRIAQVKRDADIATAEA DKETRIKRAEADKDAKKSELERATEIAEAEKINQLKMAEFRREQDTAKANADQAYDLE TARARQQVTEQEMQVKIIERQKQIELEEKEILRRERQYDSEVKKKADADRYSVEQSAA AEKAKQLAEADAKKYSIEAMAKAEAEKVRIDGLAKAEAEKAKGETEAEVIRLKGLAEA EAKEKIAAAFEQYGQAAIFDMIVKMLPEYAKQAAAPLSNIDKITVVDTGGSGESSGAN KVTSYATNLMSSLQESLKASSGIDVKEMLENFSGKGNVKQSINELTNEIKEAKTIQKS E*" /label="floT CDS" gene complement(2698710..2700239) /gene="floT" /locus_tag="BSU_31010" /old_locus_tag="BSU31010" /label="floT gene" CDS complement(2700260..2700784) /gene="nfeDB" /locus_tag="BSU_31020" /old_locus_tag="BSU31020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12533473, 15849754, 16850406, 18696230, 22753055; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane integrity integral membrane protein" /protein_id="NP_390980.1" /db_xref="EnsemblGenomes-Gn:BSU31020" /db_xref="EnsemblGenomes-Tr:CAB15080" /db_xref="GOA:O32077" /db_xref="PDB:2K14" /db_xref="SubtiList:BG13946" /db_xref="UniProtKB/Swiss-Prot:O32077" /translation="MELFGVPIQTMYLYTLIIAGSLTLLFLFFGDVFSGLSEGIPFLN PTLVLSFFTCFSAGGYIGELVLPLSSLLIALLSCILSIMLVVLLHIFVLVPLSSAEES LAYREDDLRGRLGKVITAVPVDGFGEVVIEGIGGTISKSAVSFDNQQISYGTTVLVVD INNGVLSVTPHEPI*" /label="nfeDB CDS" gene complement(2700260..2700784) /gene="nfeDB" /locus_tag="BSU_31020" /old_locus_tag="BSU31020" /label="nfeDB gene" promotor_-10 complement(2700828..2700843) /Source="Nicolas_upshift_promotors" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="promotor_-10" upshifts complement(2700834) /Source="Nicolas_upshifts" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="upshifts" S_feature complement(2700836..2700923) /Source="Nicolas_S_feature" /locus_tag="new_3182591_3182678_c" /HighExp="S4, S8, S6, S7, S5, S3, B36, LoTm, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S1183" promotor_-35 complement(2700855..2700864) /Source="Nicolas_upshift_promotors" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="promotor_-35" promotor_-10 complement(2700908..2700926) /Source="Nicolas_upshift_promotors" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2700918 /Source="Nicolas_upshifts" /id="U2404" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.442557442557443" /psig="0.962037962037962" /xcortree=633 /SigmaFactorBS="agtttcaaaattttaagacaaataacccatttgaagtgcttt ataaatgataattgcttatataTATGGTAATGTCATTTTAGGaggagatatgatgagt a" /listShort="yuaE, S1184" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2700922..2700941 /Source="Nicolas_upshift_promotors" /id="U2404" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.442557442557443" /psig="0.962037962037962" /xcortree=633 /SigmaFactorBS="agtttcaaaattttaagacaaataacccatttgaagtgcttt ataaatgataattgcttatataTATGGTAATGTCATTTTAGGaggagatatgatgagt a" /listShort="yuaE, S1184" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2700923) /Source="Nicolas_upshifts" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2700941..2700946) /Source="Nicolas_upshift_promotors" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2700952..2701440 /gene="yuaE" /locus_tag="BSU_31030" /old_locus_tag="BSU31030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390981.1" /db_xref="EnsemblGenomes-Gn:BSU31030" /db_xref="EnsemblGenomes-Tr:CAB15081" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG13945" /db_xref="UniProtKB/Swiss-Prot:O32078" /translation="MSIFNEARLETWNELKGLSDEKLNQKPSAEEWSIREVLDHLKKI DMTAQKMLKERVKDAPIKEIEEKPLEVAQDRNNKRKAPSHLEPAHDFISGSQMKRELD VVREQLTAAIASLKEEDFERVLPHPVFQELTVRQWIDFIGHHEKRHLSQMKEIKEKIE RA*" /label="yuaE CDS" gene 2700952..2701440 /gene="yuaE" /locus_tag="BSU_31030" /old_locus_tag="BSU31030" /label="yuaE gene" downshifts 2701417 /Source="Nicolas_upshifts" /id="D1600" /incds=0 /nref=205 /ntot=267 /MaxReadThrough="4.05856" /MaxDrop="6.05192" /score="-4.20632485" /energy="-15" /TU="U2404" /idTUdmin="U2404" /TUdmin="-354" /isTUend="FALSE" /label="downshifts" CDS complement(2701446..2702024) /gene="yuaD" /locus_tag="BSU_31040" /old_locus_tag="BSU31040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11886751" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390982.1" /db_xref="EnsemblGenomes-Gn:BSU31040" /db_xref="EnsemblGenomes-Tr:CAB15082" /db_xref="GOA:O32079" /db_xref="InterPro:IPR005302" /db_xref="InterPro:IPR011037" /db_xref="PDB:1ORU" /db_xref="SubtiList:BG13944" /db_xref="UniProtKB/Swiss-Prot:O32079" /translation="MWKRMTAKAEGLYIADTKSFVTKQMDKLDFDYGGIPGDLHFGLT KKAGAREPMFSRGTEIFNRRQISIVSIEECNEIALKMGVPRILPEWLGANVAVSGMPD LTSLKEGSRIIFPSGAALLCEGENDPCIQPGEVIQSYYPDQPKLASAFVRHALGIRGI VCIVERPGAVYTGDEIEVHSYQRKVKRKAERV*" /label="yuaD CDS" gene complement(2701446..2702024) /gene="yuaD" /locus_tag="BSU_31040" /old_locus_tag="BSU31040" /label="yuaD gene" S_feature 2701462..2701853 /Source="Nicolas_S_feature" /locus_tag="new_3183217_3183608" /HighExp="Etha, S8, LPhT, S6, Salt, LoTm, S5, H2O2, S7, dia5" /AntisenseName="yuaD" /AntisenseCor="-0.48344313728748101" /AntisenseRegPval="-16.399999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.962" /TUlongSig="NA" /TUlongPSig="NA" /label="S1184" downshifts complement(2701473) /Source="Nicolas_upshifts" /id="D1601" /incds=0 /nref=87 /ntot=222 /MaxReadThrough="0.58189" /MaxDrop="3.9885" /score="0.718873117" /energy="-11.5" /TU="NA" /idTUdmin="U2406" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2702058..2702077) /Source="Nicolas_upshift_promotors" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2702067) /Source="Nicolas_upshifts" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2702091..2702098) /Source="Nicolas_upshift_promotors" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2702112..2703320) /gene="gbsB" /locus_tag="BSU_31050" /old_locus_tag="BSU31050" /EC_number="1.1.99.1" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752328, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 22408163; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="choline dehydrogenase" /protein_id="NP_390983.2" /db_xref="EnsemblGenomes-Gn:BSU31050" /db_xref="EnsemblGenomes-Tr:CAB15083" /db_xref="GOA:P71017" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG11941" /db_xref="UniProtKB/Swiss-Prot:P71017" /translation="MTLNMKVESMQKFHTFEIPTVIKHGIGAIKHTGEEVAALGVSKA LLVTDPGIYKAGVADPVIESLKEAGIEVVLFNKVEPNPPVRLVNEGSELYKKENCNGL VAVGGGSSMDTAKAIGVEATHEGSVLDYEAADGKKPLENRIPPLTTIPTTAGTGSEVT QWAVITDEEREFKFNTGGPLIAAHLTIIDPELHVSMPPHVTAMTGIDALAHAIECYTM KFAQPITDAVALMAIEYAAHYIKRAFADGEDLEARYGMAQAAMLAGLSYGSESAGAAH AMSQTLGGIIPVAHGQCVAAMMGPVMEYNWKGYPEKFARIAKAFGIDTSKMTTEEAAK ASVNWMYDLVEDLEVPTLEEQGVSPDMIERLSKEAMKDPQTFGNPRDLNEKAYNWIYK RCFNLTPKTV*" /label="gbsB CDS" gene complement(2702112..2703320) /gene="gbsB" /locus_tag="BSU_31050" /old_locus_tag="BSU31050" /label="gbsB gene" downshifts complement(2702133) /Source="Nicolas_upshifts" /id="D1602" /incds=0 /nref=2 /ntot=70 /MaxReadThrough="2.9443" /MaxDrop="3.26923" /score="18.315772" /energy="-13.6" /TU="NA" /idTUdmin="U2406" /TUdmin="-660" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2703089..2703108) /Source="Nicolas_upshift_promotors" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2703101) /Source="Nicolas_upshifts" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2703123..2703130) /Source="Nicolas_upshift_promotors" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2703337..2704809) /gene="gbsA" /locus_tag="BSU_31060" /old_locus_tag="BSU31060" /EC_number="1.2.1.8" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752328, 9297465, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 9297465, 22408163; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine betaine aldehyde dehydrogenase, NAD+-dependent" /protein_id="NP_390984.1" /db_xref="EnsemblGenomes-Gn:BSU31060" /db_xref="EnsemblGenomes-Tr:CAB15084" /db_xref="GOA:P71016" /db_xref="InterPro:IPR011264" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11940" /db_xref="UniProtKB/Swiss-Prot:P71016" /translation="MSQTLFIDGEWISAEKEQIRSIINPFNQEEIATVSEGGREDAIK AIAAARRAFDKGEWSSLSGLERGKIVLKIAELIRRDLEELAELESLDTGKTLEESKAD MDDIANVFQYYAGLADKDGGEIISSPIPDSESKIIREPIGVCGQITPWNYPLLQASWK IAPALAAGNTIVMKPSEITPLTTIKVFKLMEEAGVPKGVANLVLGPGATVGDELAVNK DVDLISFTGGIETGKKIMRAASGNVKKIALELGGKNPNIVFKDADLEVAVDQALNAVF FHAGQVCSAGSRLLVEDAIHDQFLAELVKRAKRIKLGNGFHAETESGPLISAEHRAKV EKYVEIGIEEGAKLETGGKRPEDPELQNGFFYEPTIFSNCNSDMRIVQEEVFGPVLTV ETFSSEEEVIELANDTIYGLAGAVWSKDIEKCERVAARLRMGTVWINDFHPYFAQAPW GGYKQSGFGRELGKIGLEEYTEVKHVYRNTKPAAVNWFNS*" /label="gbsA CDS" gene complement(2703337..2704809) /gene="gbsA" /locus_tag="BSU_31060" /old_locus_tag="BSU31060" /label="gbsA gene" promotor_-10 complement(2704860..2704879) /Source="Nicolas_upshift_promotors" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2704861) /Source="Nicolas_upshifts" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2704894..2704901) /Source="Nicolas_upshift_promotors" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2704921..2704927 /Source="Nicolas_upshift_promotors" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2704941..2704960 /Source="Nicolas_upshift_promotors" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2704956 /Source="Nicolas_upshifts" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="upshifts" CDS 2705008..2705550 /gene="gbsR" /locus_tag="BSU_31070" /old_locus_tag="BSU31070" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8752328, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 22408163; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor for gbsAB" /protein_id="NP_390985.1" /db_xref="EnsemblGenomes-Gn:BSU31070" /db_xref="EnsemblGenomes-Tr:CAB15085" /db_xref="GOA:P71015" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12342" /db_xref="UniProtKB/Swiss-Prot:P71015" /translation="MDENPEFAAIEQARDLVIDSIAETMDLYGITRSVGILYGTMYMR DEMTLDEMREELQMSKPSMSTGVKKLQDLNVVKKTFHRGIRKHTFVAEKDFFKFFTNF FPPKWEREVQVNVTAIEEAQADLQKVLCKEDLDEDIKNEALQLYDQLESSKAYYDWLK RLAESVQTGEIFKFIPVETK*" /label="gbsR CDS" gene 2705008..2705550 /gene="gbsR" /locus_tag="BSU_31070" /old_locus_tag="BSU31070" /label="gbsR gene" downshifts 2705533 /Source="Nicolas_upshifts" /id="D1603" /incds=0 /nref=74 /ntot=220 /MaxReadThrough="1.70461" /MaxDrop="3.5918" /score="26.1509691" /energy="-9.9" /TU="NA" /idTUdmin="U2409" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2705627..2705634 /Source="Nicolas_upshift_promotors" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2705647..2705747 /Source="Nicolas_S_feature" /locus_tag="new_3187402_3187502" /HighExp="BT, S0, BI, T-1.10H, T-1.40H, T1.0H, T-0.40H, T0.0H, S2, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1185" upshifts 2705647 /Source="Nicolas_upshifts" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2705649..2705668 /Source="Nicolas_upshift_promotors" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2705748..2706293 /gene="bslA" /locus_tag="BSU_31080" /old_locus_tag="BSU31080" /function="15.3: Cell adhesion" /experiment="publication(s) with functional evidences, PMID:21097620, 21742882, 22571672, 23904481, 28698374, 28701036, 28751732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21097620, 21742882, 22571672, 23904481, 28698374, 28701036, 28751732; Product type s: structure" /codon_start=1 /transl_table=11 /product="biofilm hydrophobic layer component" /protein_id="NP_390986.1" /db_xref="EnsemblGenomes-Gn:BSU31080" /db_xref="EnsemblGenomes-Tr:CAB15086" /db_xref="GOA:P71014" /db_xref="InterPro:IPR034650" /db_xref="PDB:4BHU" /db_xref="SubtiList:BG12341" /db_xref="UniProtKB/Swiss-Prot:P71014" /translation="MKRKLLSSLAISALSLGLLVSAPTASFAAESTSTKAHTESTMRT QSTASLFATITGASKTEWSFSDIELTYRPNTLLSLGVMEFTLPSGFTANTKDTLNGNA LRTTQILNNGKTVRVPLALDLLGAGEFKLKLNNKTLPAAGTYTFRAENKSLSIGNKFY AEASIDVAKRSTPPTQPCGCN*" /label="bslA CDS" gene 2705748..2706293 /gene="bslA" /locus_tag="BSU_31080" /old_locus_tag="BSU31080" /label="bslA gene" downshifts 2706280 /Source="Nicolas_upshifts" /id="D1604" /incds=0 /nref=109 /ntot=219 /MaxReadThrough="0.85027" /MaxDrop="6.00835" /score="20.8976757" /energy="-10.2" /TU="NA" /idTUdmin="U2410" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2706385..2706392 /Source="Nicolas_upshift_promotors" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2706406..2706425 /Source="Nicolas_upshift_promotors" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2706413 /Source="Nicolas_upshifts" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 2706418..2706586 /gene="swdA" /locus_tag="BSU_misc_RNA_52" /product="cyclic-di-AMP-sensing riboswitch" /experiment="publication(s) with functional evidences, PMID:20511502, 23086297, 24141192, 25086507, 25086509, 26789423, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20511502, 23086297, 24141192, 25086507, 25086509, 26789423, 28420751; Product type n: RNA" /label="swdA RNA" gene 2706418..2706586 /gene="swdA" /locus_tag="BSU_misc_RNA_52" /label="swdA gene" downshifts 2706567 /Source="Nicolas_upshifts" /id="D1605" /incds=0 /nref=16 /ntot=104 /MaxReadThrough="6.04086" /MaxDrop="4.75274" /score="3.29445061" /energy="-6.1" /TU="U2411" /idTUdmin="U2410" /TUdmin=286 /isTUend="FALSE" /label="downshifts" CDS 2706659..2707327 /gene="ktrA" /locus_tag="BSU_31090" /old_locus_tag="BSU31090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 23598340, 23671116, 25957408, 26771197" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 23598340, 23671116, 25957408, 26771197; Product type t : transporter" /codon_start=1 /transl_table=11 /product="potassium uptake protein" /protein_id="NP_390987.1" /db_xref="EnsemblGenomes-Gn:BSU31090" /db_xref="EnsemblGenomes-Tr:CAB15087" /db_xref="GOA:O32080" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="PDB:1LSU" /db_xref="PDB:2HMS" /db_xref="PDB:2HMT" /db_xref="PDB:2HMU" /db_xref="PDB:2HMV" /db_xref="PDB:2HMW" /db_xref="PDB:4J7C" /db_xref="PDB:4J90" /db_xref="PDB:4J91" /db_xref="PDB:5BUT" /db_xref="SubtiList:BG13943" /db_xref="UniProtKB/Swiss-Prot:O32080" /translation="MGRIKNKQFAVIGLGRFGGSICKELHRMGHEVLAVDINEEKVNA YASYATHAVIANATEENELLSLGIRNFEYVIVAIGANIQASTLTTLLLKELDIPNIWV KAQNYYHHKVLEKIGADRIIHPEKDMGVKIAQSLSDENVLNYIDLSDEYSIVELLATR KLDSKSIIDLNVRAKYGCTILAIKHHGDICLSPAPEDIIREQDCLVIMGHKKDIKRFE NEGM*" /label="ktrA CDS" gene 2706659..2707327 /gene="ktrA" /locus_tag="BSU_31090" /old_locus_tag="BSU31090" /label="ktrA gene" CDS 2707334..2708671 /gene="ktrB" /locus_tag="BSU_31100" /old_locus_tag="BSU31100" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 15849754, 16850406, 17932047, 23598340, 26771197, 28783096, 28825218" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 15849754, 16850406, 17932047, 23598340, 26771197, 28783096, 28825218; Product type t: transporter" /codon_start=1 /transl_table=11 /product="potassium transporter ATPase" /protein_id="NP_390988.1" /db_xref="EnsemblGenomes-Gn:BSU31100" /db_xref="EnsemblGenomes-Tr:CAB15088" /db_xref="GOA:O32081" /db_xref="InterPro:IPR003445" /db_xref="InterPro:IPR004772" /db_xref="PDB:4J7C" /db_xref="PDB:5BUT" /db_xref="SubtiList:BG13956" /db_xref="UniProtKB/Swiss-Prot:O32081" /translation="MTLQKDKVIKWVRFTPPQVLAIGFFLTIIIGAVLLMLPISTTKP LSWIDALFTAASATTVTGLAVVDTGTQFTVFGQTVIMGLIQIGGLGFMTFAVLIVMIL GKKIGLKERMLVQEALNQPTIGGVIGLVKVLFLFSISIELIAALILSIRLVPQYGWSS GLFASLFHAISAFNNAGFSLWPDNLMSYVGDPTVNLVITFLFITGGIGFTVLFDVMKN RRFKTFSLHTKLMLTGTLMLNAIAMLTVFILEYSNPGTLGHLHIVDKLWASYFQAVTP RTAGFNSLDFGSMREGTIVFTLLLMFIGAGSASTASGIKLTTFIVILTSVIAYLRGKK ETVIFRRSIKYPIIIKALAVSVTSLFIVFLGIFALTITEQAPFLQIVFETFSAFGTVG LTMGLTPELTTAGKCIIIVIMFIGRIGPLTFVFSFAKTEQSNIRYPDGEVFTG*" /label="ktrB CDS" gene 2707334..2708671 /gene="ktrB" /locus_tag="BSU_31100" /old_locus_tag="BSU31100" /label="ktrB gene" downshifts 2708657 /Source="Nicolas_upshifts" /id="D1606" /incds=0 /nref=9 /ntot=98 /MaxReadThrough="0.86883" /MaxDrop="3.37604" /score="25.8974852" /energy="-11.9" /TU="NA" /idTUdmin="U2411" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2708707..2708970) /gene="yubF" /locus_tag="BSU_31110" /old_locus_tag="BSU31110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390989.1" /db_xref="EnsemblGenomes-Gn:BSU31110" /db_xref="EnsemblGenomes-Tr:CAB15089" /db_xref="GOA:O32082" /db_xref="InterPro:IPR008024" /db_xref="SubtiList:BG13955" /db_xref="UniProtKB/Swiss-Prot:O32082" /translation="MQKYRRRNTVAFTVLAYFTFFAGVFLFSIGLYNADNLELNEKGY YIAVMILVAVGAILTQKVTRDNAEDNEIIAEQEKRQNQSHIES*" /label="yubF CDS" gene complement(2708707..2708970) /gene="yubF" /locus_tag="BSU_31110" /old_locus_tag="BSU31110" /label="yubF gene" downshifts complement(2708725) /Source="Nicolas_upshifts" /id="D1607" /incds=0 /nref=237 /ntot=309 /MaxReadThrough="2.4577" /MaxDrop="7.13564" /score="30.2020977" /energy="-11.9" /TU="NA" /idTUdmin="U2412" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2709010..2709029) /Source="Nicolas_upshift_promotors" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2709012) /Source="Nicolas_upshifts" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2709042..2709049) /Source="Nicolas_upshift_promotors" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2709079..2709927) /gene="lytG" /locus_tag="BSU_31120" /old_locus_tag="BSU31120" /EC_number="3.2.1.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12525152, 16855244, 28448118, 28811162" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12525152, 16855244, 28448118, 28811162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exoglucosaminidase" /protein_id="NP_390990.1" /db_xref="EnsemblGenomes-Gn:BSU31120" /db_xref="EnsemblGenomes-Tr:CAB15090" /db_xref="GOA:O32083" /db_xref="InterPro:IPR002901" /db_xref="InterPro:IPR025987" /db_xref="SubtiList:BG13954" /db_xref="UniProtKB/Swiss-Prot:O32083" /translation="MARKKLKKRKLLISLFFLVSIPLALFVLATTLSKPIEISKETEE IDEQQVFIDSLSGHAQILYEKYHVLPSITIAQAILESDWGNSELAAKANNLFGVKGNY KGHHVTMETDEVEKGKRKTIRAKFRKYSTFFESMDDHAQLFVRGTSWNKKKYKPVLEA GNYKEAATALQTSGYATDPDYADKISAIVEKYDLDEYDEVNPSLKSVDLNASIKDSAV QDVWSKPSTDDRSIRLTSAQSYVGKDIKVVSKKQKGQSVWYQFQINDKLIGWIDDSAV EIKEAT*" /label="lytG CDS" gene complement(2709079..2709927) /gene="lytG" /locus_tag="BSU_31120" /old_locus_tag="BSU31120" /label="lytG gene" promotor_-10 complement(2709972..2709991) /Source="Nicolas_upshift_promotors" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2709982) /Source="Nicolas_upshifts" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2710006..2710013) /Source="Nicolas_upshift_promotors" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2710088..2711623) /gene="yubD" /locus_tag="BSU_31130" /old_locus_tag="BSU31130" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 28248504; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390991.1" /db_xref="EnsemblGenomes-Gn:BSU31130" /db_xref="EnsemblGenomes-Tr:CAB15091" /db_xref="GOA:O32084" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13953" /db_xref="UniProtKB/Swiss-Prot:O32084" /translation="MKTKHYWVISLLAVLAVGPGLMSNTALSSVQGLVQKTVGTSVFT SVNPILIGNMAFALLVPAGPLLRKKFGARPVYLASLPVFILGSLLIACSGDIALMAAG RFLQGAATGVMLMIMIPMLVLSFPIERRNYALLVLIGGFYGSVIIGTILGTIATSCGH WRWLFFIFGTLSLIGVAVSYFFLHDEHHGAADQEQPLDRAGILLSVFLAAASAVSFIF LQKWGLSSGYVWIGFGVTLCLLIGLLIVEYKVKNPFISIKLMLLPKPVLGLLIIAAGT ITVAVSLSAFQGLLRQMYDISQEHLILLSLTLLIGVAIAAILSALLYDKVGPGMLGII GGLILVFVNFQWLHIQDRSSLYMFAALFIMLAAGTGLTVAAGLMGAAMGGPLPDLVKR MTAVQFLRLFVYMGVPILIGFFTKKDAARQSGSVQDSMMTAYHDLFFISFILSVLLVC LSFCMNATGMGHKLAHKPHDKAKTAPEKPAVSAQGLSKATVKSYKVINDTEYRNALRN LQK*" /label="yubD CDS" gene complement(2710088..2711623) /gene="yubD" /locus_tag="BSU_31130" /old_locus_tag="BSU31130" /label="yubD gene" downshifts complement(2710097) /Source="Nicolas_upshifts" /id="D1608" /incds=0 /nref=45 /ntot=159 /MaxReadThrough="1.39941" /MaxDrop="4.26166" /score="-3.3162201" /energy="-5.7" /TU="NA" /idTUdmin="U2415" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box 2711281..2711381 /Source="Nicolas_upshift_promotors" /id="U2414" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.407592407592408" /psig="0.127872127872128" /xcortree=1469 /SigmaFactorBS="tcagcatgacgcctgttgccgccccttgtaaaaagcgccctg ccgccatcaatgcaatatcgcctgaacatgcgatgagcagtgagcctagtataaagac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2711341 /Source="Nicolas_upshifts" /id="U2414" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.407592407592408" /psig="0.127872127872128" /xcortree=1469 /SigmaFactorBS="tcagcatgacgcctgttgccgccccttgtaaaaagcgccctg ccgccatcaatgcaatatcgcctgaacatgcgatgagcagtgagcctagtataaagac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2711407 /Source="Nicolas_upshifts" /id="D1609" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="0.0870599999999992" /MaxDrop="3.19459" /score="-1.6836786" /energy="-10.4" /TU="NA" /idTUdmin="U2416" /TUdmin="-1496" /isTUend="FALSE" /label="downshifts" S_feature complement(2711624..2711791) /Source="Nicolas_S_feature" /locus_tag="new_3193379_3193546_c" /HighExp="Cold, S8, G180, UNK1, C30, G135, S7, Lbexp, MG 25, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.34877900000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1186" promotor_-10 complement(2711780..2711799) /Source="Nicolas_upshift_promotors" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2711791) /Source="Nicolas_upshifts" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2711793..2712670) /Source="Nicolas_S_feature" /locus_tag="new_3193548_3194425_c" /HighExp="G180, Cold, C30, G135, Paraq, Oxctl, S8, G150, H2O2, Heat" /AntisenseName="cdoA" /AntisenseCor="-2.3104546834536201E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1187" promotor_-35 complement(2711814..2711821) /Source="Nicolas_upshift_promotors" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2712033..2712042 /Source="Nicolas_upshift_promotors" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2712056..2712075 /Source="Nicolas_upshift_promotors" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2712056 /Source="Nicolas_upshifts" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="upshifts" CDS 2712108..2712593 /gene="cdoA" /locus_tag="BSU_31140" /old_locus_tag="BSU31140" /EC_number="1.13.11.20" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10939241, 15699190, 16855246, 25307852, 26590284" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15699190, 16855246, 25307852, 26590284; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine dioxygenase" /protein_id="NP_390992.1" /db_xref="EnsemblGenomes-Gn:BSU31140" /db_xref="EnsemblGenomes-Tr:CAB15092" /db_xref="GOA:O32085" /db_xref="InterPro:IPR010300" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="PDB:3EQE" /db_xref="PDB:4QM8" /db_xref="PDB:4QM9" /db_xref="SubtiList:BG13952" /db_xref="UniProtKB/Swiss-Prot:O32085" /translation="MELYECIQDIFGGLKNPSVKDLATSLKQIPNAAKLSQPYIKEPD QYAYGRNAIYRNNELEIIVINIPPNKETTVHDHGQSIGCAMVLEGKLLNSIYRSTGEH AELSNSYFVHEGECLISTKGLIHKMSNPTSERMVSLHVYSPPLEDMTVFEEQKEVLEN S*" /label="cdoA CDS" gene 2712108..2712593 /gene="cdoA" /locus_tag="BSU_31140" /old_locus_tag="BSU31140" /label="cdoA gene" S_feature 2712594..2712880 /Source="Nicolas_S_feature" /locus_tag="new_3194349_3194635" /HighExp="S6, S8, S7, BT, S5, G/S, C30, Pyr, C90, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.53171800000000002" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1188" tRNA complement(2712700..2712772) /gene="trnSL-Ala1" /locus_tag="BSU_tRNA_86" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala (GGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /label="trnSL-Ala1 tRNA" gene complement(2712700..2712772) /gene="trnSL-Ala1" /locus_tag="BSU_tRNA_86" /label="trnSL-Ala1 gene" downshifts complement(2712715) /Source="Nicolas_upshifts" /id="D1610" /incds=0 /nref=37 /ntot=180 /MaxReadThrough="3.88031" /MaxDrop="4.38957" /score="19.7542652" /energy="-6.2" /TU="U2417" /idTUdmin="U2419" /TUdmin=154 /isTUend="FALSE" /label="downshifts" downshifts complement(2712759) /Source="Nicolas_upshifts" /id="D1611" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="5.34085" /MaxDrop="4.19639" /score="19.7542652" /energy="-6.2" /TU="U2417" /idTUdmin="U2419" /TUdmin=110 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2712783..2712802) /Source="Nicolas_upshift_promotors" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2712803) /Source="Nicolas_upshifts" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2712817..2712820) /Source="Nicolas_upshift_promotors" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2712837 /Source="Nicolas_upshifts" /id="D1612" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="3.04964" /MaxDrop="3.22361" /score="-1.6836786" /energy="-10.4" /TU="U2416" /idTUdmin="U2416" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2712880..2713710) /gene="uppP" /locus_tag="BSU_31150" /old_locus_tag="BSU31150" /EC_number="3.6.1.27" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15138271, 15849754, 16850406, 27528508, 27578312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15138271, 15849754, 16850406, 27528508, 27578312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl-pyrophosphate phosphatase" /protein_id="NP_390993.1" /db_xref="EnsemblGenomes-Gn:BSU31150" /db_xref="EnsemblGenomes-Tr:CAB15093" /db_xref="GOA:P94507" /db_xref="InterPro:IPR003824" /db_xref="SubtiList:BG13951" /db_xref="UniProtKB/Swiss-Prot:P94507" /translation="MTLWELFVAAILGIVEGLTEYAPVSSTGHMIIVDDIWLKSSNLM SEEAANSFKVVIQLGSILAVAIVFKDRILNLLGLKKNITSDQEQGHKLSIAQIAVGLV PAAVLGFLFEDYIDEYLFSVKTVAIGLIAGAILMLFADWVNKRKTATDTLDRISYKQA IAVGLFQCLSLWPGFSRSGSTISGGVILGLNHRAAADFTFIMAMPIMMGASFLSLVKH WDSLSSDLMPFFIVGFICAFVVALFVVRFFLRLINKIKLVPFAIYRIILGVILLLIMM *" /label="uppP CDS" gene complement(2712880..2713710) /gene="uppP" /locus_tag="BSU_31150" /old_locus_tag="BSU31150" /label="uppP gene" downshifts complement(2712891) /Source="Nicolas_upshifts" /id="D1613" /incds=0 /nref=60 /ntot=208 /MaxReadThrough="3.0552" /MaxDrop="5.61932" /score="-4.25033697" /energy="-6.7" /TU="U2419" /idTUdmin="U2419" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" S_feature complement(2713711..2713802) /Source="Nicolas_S_feature" /locus_tag="new_3195466_3195557_c" /HighExp="dia15, H2O2, Salt, Etha, dia5, LBGtran, M0t90, Lbstat, Mt0, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1189" CDS complement(2713803..2714969) /gene="yubA" /locus_tag="BSU_31160" /old_locus_tag="BSU31160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16385049, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390994.1" /db_xref="EnsemblGenomes-Gn:BSU31160" /db_xref="EnsemblGenomes-Tr:CAB15094" /db_xref="GOA:O32086" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13950" /db_xref="UniProtKB/Swiss-Prot:O32086" /translation="METLQTWSGRFKRFFLDNKFVLFLLVLLLIGLNILVFTKTSFIF TPIIVLLKTISLPIILTGIVFYLLNPVVDFLERRRIRRIYSILLLYLLVIGLITITIV SIIPFLKEQIMSLIDNIPRYVDVVENQTKQLIGSNFVNQAQQTMNINISDLATKVSDQ AATIVNSTFTGVGNFIGALTEIIISIVTVPFILFYLLKDGRKLPVYILKFVPTRLKEQ TYTVLSEMNHRLSSYIRGQIIVSFCIGFLLFIGYLIIGLDYASLLAVIAACTSIVPYL GPTIAITPAIIIAIVTSPLMLLKLVIVWTIVQLIEGKLISPQIMGKNLHIHPITIIFL LLTAGKLFGVVGIILAIPGYAVAKVITTHLFDWFKMQSHLYDEEKNENTPGHKV*" /label="yubA CDS" gene complement(2713803..2714969) /gene="yubA" /locus_tag="BSU_31160" /old_locus_tag="BSU31160" /label="yubA gene" promotor_-35 2714965..2714969 /Source="Nicolas_upshift_promotors" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2714977..2714991 /Source="Nicolas_upshift_promotors" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2714993..2715012) /Source="Nicolas_upshift_promotors" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2714993 /Source="Nicolas_upshifts" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2715012) /Source="Nicolas_upshifts" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2715026..2715033) /Source="Nicolas_upshift_promotors" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2715091..2715098 /Source="Nicolas_upshift_promotors" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2715104 /Source="Nicolas_upshifts" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2715109..2715128 /Source="Nicolas_upshift_promotors" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2715151..2716137 /gene="iolU" /locus_tag="BSU_31170" /old_locus_tag="BSU31170" /EC_number="1.1.1.371" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12450853, 28043209" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12450853, 28043209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol dehydrogenase (NADP+-dependent);biofilm formation" /protein_id="NP_390995.1" /db_xref="EnsemblGenomes-Gn:BSU31170" /db_xref="EnsemblGenomes-Tr:CAB15095" /db_xref="GOA:O05265" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12388" /db_xref="UniProtKB/Swiss-Prot:O05265" /translation="MIRFAIIGTNWITDRFLESAADIEDFQLTAVYSRSAERAGEFAA KHNAAHAFSDLQEMAASDCFDAVYIASPNALHKEQAVLFMNHGKHVLCEKPFASNTKE TEEMISAAKANGVVLMEAMKTTFLPNFKELKKHLHKIGTVRRFTASYCQYSSRYDAFR SGTVLNAFQPELSNGSLMDIGVYCIYPAVVLFGAPKDVKANGYALSSGVDGEGTVILS YDGFEAVLMHSKISTSYAPAEIQGEDGTIVIDTIHRPERVEIRYRDGRLENIAIPDPK PAMFYEAEEFVTLIKENKLESEENTFERSLTTAKIMEEARKQMGIVYPADQA*" /label="iolU CDS" gene 2715151..2716137 /gene="iolU" /locus_tag="BSU_31170" /old_locus_tag="BSU31170" /label="iolU gene" downshifts 2716108 /Source="Nicolas_upshifts" /id="D1614" /incds=0 /nref=30 /ntot=279 /MaxReadThrough="1.83109" /MaxDrop="4.96985" /score="21.8997198" /energy="-15.1" /TU="NA" /idTUdmin="U2420" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2716178..2717452) /gene="rhaA" /locus_tag="BSU_31180" /old_locus_tag="BSU31180" /EC_number="5.3.1.14" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10960106, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10960106, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-rhamnose isomerase" /protein_id="NP_390996.1" /db_xref="EnsemblGenomes-Gn:BSU31180" /db_xref="EnsemblGenomes-Tr:CAB15096" /db_xref="GOA:O05264" /db_xref="InterPro:IPR009308" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG12387" /db_xref="UniProtKB/Swiss-Prot:O05264" /translation="MTIKANYDSAKQAYEKWGIDVEEALRQLEQVPISIHCWQGDDIE GFEVNKGELSGGIDVTGNYPGKAQTPEELRRDLEKALSLIPGKHRVNLHAIYAETNRE AVERDELKPQHFENWVKWAKNLGLGLDFNPTLFSHEKAADGLTLSHPDPDIREFWIRH CIACRRIGEYFGKELGTPCLTNIWIPDGYKDIPSDRLTPRKRLKESLDRIFSEEISEQ HNLDSIESKLFGLGSESYVVGSHEFYLAYALTNHKLCLLDTGHFHPTETVSNKISSML LYTDKLALHVSRPVRWDSDHVVVLDDELREIALEIVRNHALEKVAIGLDFFDASINRV AAWTIGTRNMIKALLYALLLPNGYLKQLQEEGRYTERLALMEEFKTYPFGAIWDSYCE QMGVPVKEAWLYDIKEYEQQVLLKRKASSPIV*" /label="rhaA CDS" gene complement(2716178..2717452) /gene="rhaA" /locus_tag="BSU_31180" /old_locus_tag="BSU31180" /label="rhaA gene" downshifts complement(2716191) /Source="Nicolas_upshifts" /id="D1615" /incds=0 /nref=3 /ntot=29 /MaxReadThrough="0.802" /MaxDrop="4.45322" /score="14.0829844" /energy="-12.6" /TU="NA" /idTUdmin="U2421" /TUdmin=242 /isTUend="FALSE" /label="downshifts" CDS complement(2717478..2717792) /gene="rhaM" /locus_tag="BSU_31190" /old_locus_tag="BSU31190" /EC_number="5.1.3.32" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15576793, 15876375, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576793, 15876375, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-rhamnose mutarotase" /protein_id="NP_390997.1" /db_xref="EnsemblGenomes-Gn:BSU31190" /db_xref="EnsemblGenomes-Tr:CAB15097" /db_xref="GOA:O05263" /db_xref="InterPro:IPR008000" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR013448" /db_xref="SubtiList:BG12386" /db_xref="UniProtKB/Swiss-Prot:O05263" /translation="MKRKASIMFVHQDKYEEYKQRHDDIWPEMAEALKAHGAHHYSIF LDEETGRLFAYLEIEDEEKWRKMADTEVCQRWWKSMAPLMKTNSDFSPVAIDLKEVFY LD*" /label="rhaM CDS" gene complement(2717478..2717792) /gene="rhaM" /locus_tag="BSU_31190" /old_locus_tag="BSU31190" /label="rhaM gene" CDS complement(2717810..2719267) /gene="rhaB" /locus_tag="BSU_31200" /old_locus_tag="BSU31200" /EC_number="2.7.1.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16674975, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16674975, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnulokinase" /protein_id="NP_390998.1" /db_xref="EnsemblGenomes-Gn:BSU31200" /db_xref="EnsemblGenomes-Tr:CAB15098" /db_xref="GOA:O05262" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR013449" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG12385" /db_xref="UniProtKB/Swiss-Prot:O05262" /translation="MIYTAIDVGASSGRIMVGELNEGKLDIQEIHRFANGFSQRDGHC LWDIDHLLKQILQGLQKVKTLGYEHCTVGIDTWAVDYVLLDEKGDRLREAISYRDRRT DHTIDKLEHTLSKAAIYQKTGIQFQPFNTIYQLFEEDRELLKKTDKIMMIPDYLGYCL TGKAVTEITNVSTTQLLNVSTGNLDPELLEAVSVLEQQFAPLTEPGCELGKLRNEWFP DYDLPACKVMTVATHDTASAVIAAPGVNDGWAYISSGTWSLIGVENKTPIITDLALEN NYTNERGANNTIRFLKNIIGMWVIQEVKQQLQADYSFQQLAEEAKKTEPFQQFINLND KRFLNPENMIKEIQHYCRQTRQKIPRTAGELACCIYSNLAIIYAIAIKELETITEKPI EQFHIIGGGARNDFLNQLTADMSGKAVYAGPIEATATGNLLMQMIAAKEVKDIKEARQ VVRNSFPIKVFTPKDIDRSTIIQSFQQTVLKALSK*" /label="rhaB CDS" gene complement(2717810..2719267) /gene="rhaB" /locus_tag="BSU_31200" /old_locus_tag="BSU31200" /label="rhaB gene" CDS complement(2719272..2720048) /gene="rhaR" /locus_tag="BSU_31210" /old_locus_tag="BSU31210" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11496004, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11496004, 26712933; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the rhamnose operon(RhaR / l-rhamnulose-1-phosphate)" /protein_id="NP_390999.1" /db_xref="EnsemblGenomes-Gn:BSU31210" /db_xref="EnsemblGenomes-Tr:CAB15099" /db_xref="GOA:O05261" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12384" /db_xref="UniProtKB/Swiss-Prot:O05261" /translation="MLVAERQQKIVEIVNMRSSIRVSELSDIFSVTEETIRRDLEKLE KEHKLSRSHGGAVSIQQKESEIHFSEREITNVIEKKAIAHEAAKYVKSGDRIILDAST TAWYMAKILPDIELTVITNSMKAAIELSNKENISVISTGGILLEKSLSFAGPLAERSL ETYHVNKTFLSCKGFDVHNGMSDSNEWQALLKKRMIERSDQTILMADSSKWGNREFSH IASLQDVSRLITDSGLDPASVKALEDKKVKVTAVPLSKRG*" /label="rhaR CDS" gene complement(2719272..2720048) /gene="rhaR" /locus_tag="BSU_31210" /old_locus_tag="BSU31210" /label="rhaR gene" misc_feature complement(2720082..2720101) /Source="Nicolas_upshift_promotors" /id="U2421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3189 /SigmaFactorBS="acgggctgcatgatcacggtagacggcggcgtccctgctgct tttacgcgttagataTATGCTATGATAAAAATATAagacggactacgatatgaggaag g" /listShort="yulB, yulC, yulD, yulE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2720098) /Source="Nicolas_upshifts" /id="U2421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3189 /SigmaFactorBS="acgggctgcatgatcacggtagacggcggcgtccctgctgct tttacgcgttagataTATGCTATGATAAAAATATAagacggactacgatatgaggaag g" /listShort="yulB, yulC, yulD, yulE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2720105..2722174) /gene="rhaE" /locus_tag="BSU_31220" /old_locus_tag="BSU31220" /EC_number="1.1.1.-" /EC_number="4.1.2.19" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:24391637, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24391637, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional rhamnulose-1-phosphate aldolase/alcohol dehydrogenase" /protein_id="NP_391000.1" /db_xref="EnsemblGenomes-Gn:BSU31220" /db_xref="EnsemblGenomes-Tr:CAB15100" /db_xref="GOA:P40747" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR013454" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG10947" /db_xref="UniProtKB/Swiss-Prot:P40747" /translation="MVKHIWDSERAAQLPKGVEELVYRSNLIGSDRTVCNWGGGNTSM KTTEKDFRGREIEVMWVKGSGSDLATMKAHNFSGLKLDDIRPLIKRDQMPDEEMVDYL SHCMIDSKHPRPSIETLLHAFLPYKHVDHTHPDAIISICCADNGKQIAEDIYGNRFVW VPYVRPGFTLSKMIAEGVANNPHAELVLMEKHGLVTWGETSETCYQKTISIIQEAEQY INDRINQHEVFGGKRYQPLPEDKRKQILAGIMPVIRGAVSEEKKMILSYDDHDDVLEF VNSVQAPALSQIGAACPDHLVHTKRVPLYIDWNPETQDVHKLADLIKSGVETFTSEYQ AYFTRNQQDGDQIFESAPRVILIPGIGMVNTGKSYAMSKVSGALYRRAIAVMKGATAL GQFVSLHENESYHVEYWPLELYKLTLAPPEAEFSRKVALITGGAGGIGSAACRRFAAE GGHVIVADLNIEGAQKIAGEINDAYGKGRAMAVKMDVTKEEDVQSAFERAALAYGGID IVVNNAGLATSSPFDETSLKEWNLNMNVLGTGYFLVAREAFKQMKHQNRGGSMVFVGS KNSVYAGKNASAYSSVKALETHLARCIAAEGGEFGIRVNSVLPDAVLQGSAIWGSSWR EERAAAYGIEPDQLEEHYRKRTALLVNIYPEDIAEAIAFFASSKAEKTTGCMITVDGG VPAAFTR*" /label="rhaE CDS" gene complement(2720105..2722174) /gene="rhaE" /locus_tag="BSU_31220" /old_locus_tag="BSU31220" /label="rhaE gene" promotor_-10 complement(2722207..2722226) /Source="Nicolas_upshift_promotors" /id="U2422" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=1572 /SigmaFactorBS="tttttttgttaaaaagcaaaaataaacaaaaacGATTCAAaa acaaacagaaaTCATATATAATGAAAACGGAtacaaataaaagggtatggaggaatat c" /listShort="yuxG, yulB, yulC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2722219) /Source="Nicolas_upshifts" /id="U2422" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=1572 /SigmaFactorBS="tttttttgttaaaaagcaaaaataaacaaaaacGATTCAAaa acaaacagaaaTCATATATAATGAAAACGGAtacaaataaaagggtatggaggaatat c" /listShort="yuxG, yulB, yulC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2722240..2722246) /Source="Nicolas_upshift_promotors" /id="U2422" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=1572 /SigmaFactorBS="tttttttgttaaaaagcaaaaataaacaaaaacGATTCAAaa acaaacagaaaTCATATATAATGAAAACGGAtacaaataaaagggtatggaggaatat c" /listShort="yuxG, yulB, yulC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2722312..2724300) /gene="tlpB" /locus_tag="BSU_31230" /old_locus_tag="BSU31230" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:8188684, 10825179, 14563871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8188684, 10825179, 14563871; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_391001.1" /db_xref="EnsemblGenomes-Gn:BSU31230" /db_xref="EnsemblGenomes-Tr:CAB15101" /db_xref="GOA:P39217" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10862" /db_xref="UniProtKB/Swiss-Prot:P39217" /translation="MGKFIQWIKQPSISKPLIAAFLAVLILPVGVLAYFSYQSAWNAL DRELISSAKGNVEELNSTLQNKLEDKVKAIDYYSETVDKDILLGKNKTLLKEKFKQYT TLNDDVGAIYAASEDKKLYKYPDSGVPKGFDPTGRDWYKQAVAEKGQAVFSEPYTDEA TGDIVVTISKQLKDGSGVIALDLNLDEVLTASKRIKIGKEGFAFITTGNKKYIAHPTI KPGTTGSGDWTNQVYSKKEGSFEYTFEGKEKKMAFTTNKLTGWKIAGTYFVSELQDAS SPVLNTAVIILCVSIVIGGILILYIIRAITKPLRKLVSTSAKISSGDLTEVIDIHSKN EFGQLGESFNEMSASLRSVIGVIQTSVENVASSSEELTASAAQTSKATEHITLAIEQF SDGNEAQSEKLETSSNHLSQMNEGISKVAQASSTITKSSIQSSEAAGSGEKLVEHTVG QMKTIDQSVQKAEAVVKGLETKSQDITSILNVINGIADQTNLLALNAAIEAARAGEYG RGFSVVAEEVRKLAVQSADSAKEIEGLIQEIVREISTSLSMFQSVNHEVKEGLQITDQ TAESFKQIYEMTTQISGELQNLNATVEQLSAGSQEVSSAVEDISAVAKESSAGIQDIA ASAEEQLASMEEISSSAETLANMAEELQDITKKFKIES*" /label="tlpB CDS" gene complement(2722312..2724300) /gene="tlpB" /locus_tag="BSU_31230" /old_locus_tag="BSU31230" /label="tlpB gene" downshifts complement(2722331) /Source="Nicolas_upshifts" /id="D1616" /incds=0 /nref=108 /ntot=174 /MaxReadThrough="3.32915" /MaxDrop="6.75141" /score="18.7221191" /energy="-8.3" /TU="NA" /idTUdmin="U2423" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 2724304..2724311 /Source="Nicolas_upshift_promotors" /id="U2424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.426573426573427" /psig="0.735264735264735" /xcortree=662 /SigmaFactorBS="ttgtatgaattttcccattctCGTTGACTcctcctttaagat aaATCTAATATCGTCAAACTAGgataaaaggtttaataaaaaaactaaaaaaaacacc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2724321..2724339) /Source="Nicolas_upshift_promotors" /id="U2423" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2793 /SigmaFactorBS="ttgttgcgcttgggtgttttttttagtttttttaTTAAACCT tttatcctagtttGACGATATTAGATTTATCTtaaaggaggagtcaacgagaatggga a" /listShort="tlpB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2724327..2724346 /Source="Nicolas_upshift_promotors" /id="U2424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.426573426573427" /psig="0.735264735264735" /xcortree=662 /SigmaFactorBS="ttgtatgaattttcccattctCGTTGACTcctcctttaagat aaATCTAATATCGTCAAACTAGgataaaaggtttaataaaaaaactaaaaaaaacacc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2724334) /Source="Nicolas_upshifts" /id="U2423" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2793 /SigmaFactorBS="ttgttgcgcttgggtgttttttttagtttttttaTTAAACCT tttatcctagtttGACGATATTAGATTTATCTtaaaggaggagtcaacgagaatggga a" /listShort="tlpB" /GFF_Attribute="listLong" /label="upshifts" upshifts 2724343 /Source="Nicolas_upshifts" /id="U2424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.426573426573427" /psig="0.735264735264735" /xcortree=662 /SigmaFactorBS="ttgtatgaattttcccattctCGTTGACTcctcctttaagat aaATCTAATATCGTCAAACTAGgataaaaggtttaataaaaaaactaaaaaaaacacc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2724353..2724360) /Source="Nicolas_upshift_promotors" /id="U2423" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2793 /SigmaFactorBS="ttgttgcgcttgggtgttttttttagtttttttaTTAAACCT tttatcctagtttGACGATATTAGATTTATCTtaaaggaggagtcaacgagaatggga a" /listShort="tlpB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2724409 /Source="Nicolas_upshifts" /id="D1617" /incds=0 /nref=4 /ntot=11 /MaxReadThrough="1.04089" /MaxDrop="4.2056" /score="13.4355481" /energy="-10.7" /TU="NA" /idTUdmin="U2424" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(2724414..2726399) /gene="mcpA" /locus_tag="BSU_31240" /old_locus_tag="BSU31240" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:8188684, 9721285, 12011078" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8188684, 9721285, 12011078; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_391002.2" /db_xref="EnsemblGenomes-Gn:BSU31240" /db_xref="EnsemblGenomes-Tr:CAB15102" /db_xref="GOA:P39214" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10861" /db_xref="UniProtKB/Swiss-Prot:P39214" /translation="MKKILQLIKQRSITRKLLVSFLSILIIPVVILAIFAYQSASSSL DRQMMGSALENVQQLNEIINTSIGEKENSADYFSEWLTKEKYNAKSNASIAEKFSQYI SINKDVESIYTSDTKGHFTRYPDLPMPSGYNPVERDWYKKAVANKGKVVITDPYKTAS TNTMVVTIAQQTKDGSGVIAINMTIENLLKTTKKVNIGTQGYAFIMTKDKKVVAHPNE QSGTELKGDWLDKMLSADKGDFQYTMDGDKKKMAFDTNKLTGWKIGGTMYLDEIHEAA QPVLHLALIVLAAAIIIGIIVMTLIIRSITTPLKQLVGSSKRISEGDLTETIDIRSKD ELGELGKSFNNMASSLRSLIHAIQDSVDNVAASSEELTASAAQTSKATEHITLAIEQF SNGNEKQNENIETAAEHIYQMNDGLTNMAQASEVITDSSVQSTEIASEGGKLVHQTVG QMNVIDKSVKEAEQVVRGLETKSKDITNILRVINGIADQTNLLALNAAIEAARAGEYG RGFSVVAEEVRKLAVQSADSAKEIEGLIIEIVKEINTSLGMFQSVNQEVQTGLDITDK TEMSFKRISEMTNQIAGELQNMSATVQQLSASSEEVSGASEHIASISKESSAHIQDIA ASAEEQLASMEEISSSAETLSSMAEELRDMTKRFKIE*" /label="mcpA CDS" gene complement(2724414..2726399) /gene="mcpA" /locus_tag="BSU_31240" /old_locus_tag="BSU31240" /label="mcpA gene" downshifts complement(2724419) /Source="Nicolas_upshifts" /id="D1618" /incds=0 /nref=196 /ntot=232 /MaxReadThrough="3.11319" /MaxDrop="7.54297" /score="40.6270404" /energy="-13.6" /TU="U2425" /idTUdmin="U2425" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2726420..2726438) /Source="Nicolas_upshift_promotors" /id="U2425" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2798 /SigmaFactorBS="aattagttacttttgttaaatttcttcttttttgctGTATAT ATttacccatttccaGCCGATATGAAGGGTAGCAtaaaaaaggagaaatgaatgatga a" /listShort="mcpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2726435) /Source="Nicolas_upshifts" /id="U2425" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2798 /SigmaFactorBS="aattagttacttttgttaaatttcttcttttttgctGTATAT ATttacccatttccaGCCGATATGAAGGGTAGCAtaaaaaaggagaaatgaatgatga a" /listShort="mcpA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2726437..2726524) /Source="Nicolas_S_feature" /locus_tag="new_3208192_3208279_c" /HighExp="GM 150, T0.0H, T-1.40H, T-0.40H, MG 150, T-5.40H, T-3.40H, T-1.10H, T-2.40H, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1190" promotor_-35 complement(2726452..2726459) /Source="Nicolas_upshift_promotors" /id="U2425" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2798 /SigmaFactorBS="aattagttacttttgttaaatttcttcttttttgctGTATAT ATttacccatttccaGCCGATATGAAGGGTAGCAtaaaaaaggagaaatgaatgatga a" /listShort="mcpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2726525..2728513) /gene="tlpA" /locus_tag="BSU_31250" /old_locus_tag="BSU31250" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:8188684, 10825179, 14563871, 26522943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8188684, 10825179, 14563871, 26522943; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein (membrane curvature dependent localisation)" /protein_id="NP_391003.1" /db_xref="EnsemblGenomes-Gn:BSU31250" /db_xref="EnsemblGenomes-Tr:CAB15103" /db_xref="GOA:P39216" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10860" /db_xref="UniProtKB/Swiss-Prot:P39216" /translation="MKKTLTTIRRSSIARRLIISFLLILIVPITALSVSAYQSAVASL DVQMTQSAKENVQILDHIIDDKISTTEKSLAYFSDWATAEKFQDKKKTELKQEFKQFI QMNDNVAAVFSSGKDGDFTRYPYADMPSDFNALERDWYKEAMANKGKTIVTEPYESIS SGKMVVTIARQTVDGSGVVAIDMKIDDLVTTAKGINIGKEGYAFILSQNKKVIAYSGE KAGTELKGDWVDKLYKDKSGDFEYTYKGKKKKMAFATSQTTGWKISGTMYANEIHDAA SRVLIMASIVLAIAIGAGMTAIYFVIRSITKPLRRIVASAEKISEGDLTETIEINSKD ELGVLSESFNHMAHSLRSLIHGIKDSVEHVASSSEELTASADQTSRATEHITMAIEQF SNGSESQSEKIETTTEQINEMNDGLAELARAAAVITETSADSTEVSSKGETLVQKTAG QMNTIDHSVKAAEQVVKGLEIKSKDITNILRVINGIADQTNLLALNAAIEAARAGEYG RGFSVVAEEVRKLAVQSADSAKEIESLISEIVKEIHTSLNVLQSVNKEVETGLVMTDE TKQSFKHISQMTNQIASELQNMNATVEELSAGAQEISAASNDITAISKESSDGIQDIA ASAEEQLASMEEISSSALTLERMSEELRDLTKQFKVDK*" /label="tlpA CDS" gene complement(2726525..2728513) /gene="tlpA" /locus_tag="BSU_31250" /old_locus_tag="BSU31250" /label="tlpA gene" promotor_-10 complement(2728538..2728556) /Source="Nicolas_upshift_promotors" /id="U2426" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2835 /SigmaFactorBS="atttagaactatttttcattttttcctccattttcaATGTAA TTtaaaggaagatccGCCGATATAATTTGTAAATtattgaaagaaggttcaaaaggaa a" /listShort="tlpA, S1190" /listLong="mcpA" /label="promotor_-10" upshifts complement(2728553) /Source="Nicolas_upshifts" /id="U2426" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2835 /SigmaFactorBS="atttagaactatttttcattttttcctccattttcaATGTAA TTtaaaggaagatccGCCGATATAATTTGTAAATtattgaaagaaggttcaaaaggaa a" /listShort="tlpA, S1190" /listLong="mcpA" /label="upshifts" promotor_-35 complement(2728570..2728577) /Source="Nicolas_upshift_promotors" /id="U2426" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2835 /SigmaFactorBS="atttagaactatttttcattttttcctccattttcaATGTAA TTtaaaggaagatccGCCGATATAATTTGTAAATtattgaaagaaggttcaaaaggaa a" /listShort="tlpA, S1190" /listLong="mcpA" /label="promotor_-35" CDS complement(2728690..2730678) /gene="mcpB" /locus_tag="BSU_31260" /old_locus_tag="BSU31260" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:12011078, 14731274, 15317802, 15544802, 19901023, 20864474, 22931217, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12011078, 14731274, 15317802, 15544802, 19901023, 20864474, 22931217, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_391004.2" /db_xref="EnsemblGenomes-Gn:BSU31260" /db_xref="EnsemblGenomes-Tr:CAB15104" /db_xref="GOA:P39215" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10859" /db_xref="UniProtKB/Swiss-Prot:P39215" /translation="MKTFINWLKKPSISKKLIVSFIAILIIPILILEFSSYRSASGKL DQEIMGNAKNSVDTFNTTVTNDLGEKAKAVTFFSESLKRSAFKGKSNQEEIKAKFSQY VSINQGVARIYGGADNGTYVQAPKEKLPEGYDPRQRPWYQDAMKAGGEIVVTDPYVAA SDGSMVITIAQELKDGSGVVAMDITIDKLLEQMKQIKVGKEGYAFIATKNKTYVAHKN HKAGEKLSGDWVAKMYANDSGELQYTLNNEDKKMTYTTNELTGWKIAGTMYMDEIKDA SKSVLTTGMIVLIASIVAGGILILFIVRSITKPLKRLVQSSKTISRGDLTETIEIHSK DELGELGESFNEMGQSLRSLISAIQDSVNNVAASSEQLTASAGQTSKATEHITMAIEQ FSNGNEEQSEKVESSSHQLNLMNEGLQQVSQTSSDITKASIQSTEIAGTGEKFVQQTV GQMNSINQSVQQAEAVVKGLEGKSKDITSILRVINGIADQTNLLALNAAIEAARAGES GRGFSVVAEEVRKLAVQSADSAKEIEKLIQEIVAEIDTSLHMFKEVNQEVQSGLVVTD NTKESFQSIFSMTNEIAGKLQTMNSTVEQLSDRSQHVSAAVSGIADVSKESSASIQDI AASAEEQLASMEEISSSATTLAQMAEELRDLTKQFKIE*" /label="mcpB CDS" gene complement(2728690..2730678) /gene="mcpB" /locus_tag="BSU_31260" /old_locus_tag="BSU31260" /label="mcpB gene" downshifts complement(2728709) /Source="Nicolas_upshifts" /id="D1619" /incds=0 /nref=136 /ntot=224 /MaxReadThrough="3.76161" /MaxDrop="7.09773" /score="30.8363643" /energy="-10.7" /TU="U2427" /idTUdmin="U2427" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2730699..2730717) /Source="Nicolas_upshift_promotors" /id="U2427" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2799 /SigmaFactorBS="aaaaaggcagaagacagccaaaaagaacttcttccatttttt aTTTTAAAActtttttaagcaGCCGATATATACTGTATCAaacctgaaggagcaagtg a" /listShort="mcpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2730720) /Source="Nicolas_upshifts" /id="U2427" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2799 /SigmaFactorBS="aaaaaggcagaagacagccaaaaagaacttcttccatttttt aTTTTAAAActtttttaagcaGCCGATATATACTGTATCAaacctgaaggagcaagtg a" /listShort="mcpB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2730730..2730737) /Source="Nicolas_upshift_promotors" /id="U2427" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2799 /SigmaFactorBS="aaaaaggcagaagacagccaaaaagaacttcttccatttttt aTTTTAAAActtttttaagcaGCCGATATATACTGTATCAaacctgaaggagcaagtg a" /listShort="mcpB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2730780..2730789 /Source="Nicolas_upshift_promotors" /id="U2428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1304 /SigmaFactorBS="ggaagaagttctttttggctgtcttctgccttttTAACTTTC ATtgcccaagctcttTGCATATCTTATAAAAAACAaggggggctaaacatgattattg t" /listShort="tgl, S1191" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2730803..2730822 /Source="Nicolas_upshift_promotors" /id="U2428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1304 /SigmaFactorBS="ggaagaagttctttttggctgtcttctgccttttTAACTTTC ATtgcccaagctcttTGCATATCTTATAAAAAACAaggggggctaaacatgattattg t" /listShort="tgl, S1191" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2730806 /Source="Nicolas_upshifts" /id="U2428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1304 /SigmaFactorBS="ggaagaagttctttttggctgtcttctgccttttTAACTTTC ATtgcccaagctcttTGCATATCTTATAAAAAACAaggggggctaaacatgattattg t" /listShort="tgl, S1191" /GFF_Attribute="listLong" /label="upshifts" CDS 2730836..2731573 /gene="tgl" /locus_tag="BSU_31270" /old_locus_tag="BSU31270" /EC_number="2.3.2.13" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9692191, 16267299, 16751597, 16936016, 18249137, 26322858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9692191, 16267299, 16751597, 16936016, 18249137, 26322858; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein-glutamine gamma-glutamyltransferase (transglutaminase)" /protein_id="NP_391005.1" /db_xref="EnsemblGenomes-Gn:BSU31270" /db_xref="EnsemblGenomes-Tr:CAB15105" /db_xref="GOA:P40746" /db_xref="InterPro:IPR020916" /db_xref="PDB:4P8I" /db_xref="PDB:4PA5" /db_xref="SubtiList:BG10946" /db_xref="UniProtKB/Swiss-Prot:P40746" /translation="MIIVSGQLLRPQDIENWQIDQDLNPLLKEMIETPVQFDYHSIAE LMFELKLRMNIVAAAKTLHKSGAKFATFLKTYGNTTYWRVSPEGALELKYRMPPSKAI RDIAENGPFYAFECATAIVIIYYLALIDTIGEDKFNASFDRIILYDWHYEKLPIYTET GHHFFLGDCLYFKNPEFDPQKAQWRGENVILLGEDKYFAHGLGILNGKQIIDKLNSFR KKGALQSAYLLSQATRLDVPSLFRIVR*" /label="tgl CDS" gene 2730836..2731573 /gene="tgl" /locus_tag="BSU_31270" /old_locus_tag="BSU31270" /label="tgl gene" promotor_-10 complement(2730861..2730880) /Source="Nicolas_upshift_promotors" /id="U2429" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1815 /SigmaFactorBS="caatcatctcttttaagagcggattcagaTCTTGatcaatct gccaattTTCAATATCCTGGGGACGGAgcaattgtcctgatacaataatcatgtttag c" /GFF_Attribute="listShort" /listLong="mcpB" /label="promotor_-10" upshifts complement(2730869) /Source="Nicolas_upshifts" /id="U2429" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1815 /SigmaFactorBS="caatcatctcttttaagagcggattcagaTCTTGatcaatct gccaattTTCAATATCCTGGGGACGGAgcaattgtcctgatacaataatcatgtttag c" /GFF_Attribute="listShort" /listLong="mcpB" /label="upshifts" promotor_-35 complement(2730896..2730900) /Source="Nicolas_upshift_promotors" /id="U2429" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1815 /SigmaFactorBS="caatcatctcttttaagagcggattcagaTCTTGatcaatct gccaattTTCAATATCCTGGGGACGGAgcaattgtcctgatacaataatcatgtttag c" /GFF_Attribute="listShort" /listLong="mcpB" /label="promotor_-35" S_feature 2731574..2734394 /Source="Nicolas_S_feature" /locus_tag="new_3213329_3216149" /HighExp="S6, S8, S7, BT, S5, C30, B36, Pyr, BC, C90" /AntisenseName="yugT" /AntisenseCor="0.63350809138227804" /AntisenseRegPval="-30.9" /CDS_PredictionProba="0.61985900000000005" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1191" CDS complement(2731587..2731841) /gene="yuzH" /locus_tag="BSU_31279" /old_locus_tag="BSU31279" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097776.1" /db_xref="EnsemblGenomes-Gn:BSU31279" /db_xref="EnsemblGenomes-Tr:CAX52682" /db_xref="UniProtKB/Swiss-Prot:C0H3Q3" /translation="MNILQYSYKKRGKIEFVFEGWPHSKVTMVPIKGYYFVRFIKWSS QDPIVTRNDLEKMEWAANQYFGTAPFYRKRKAFETPSSGK*" /label="yuzH CDS" gene complement(2731587..2731841) /gene="yuzH" /locus_tag="BSU_31279" /old_locus_tag="BSU31279" /label="yuzH gene" downshifts complement(2731613) /Source="Nicolas_upshifts" /id="D1620" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="2.39206" /MaxDrop="2.92958" /score="-2.51333596" /energy="-14.7" /TU="NA" /idTUdmin="U2430" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2731842..2732098) /Source="Nicolas_S_feature" /locus_tag="new_3213597_3213853_c" /HighExp="Etha, Sw, Salt, Gly, BC, M9-stat, Lbstat, Heat, LPhT, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37980700000000001" /TUshortSig="SigB" /TUshortPSig="0.969" /TUlongSig="NA" /TUlongPSig="NA" /label="S1192" CDS complement(2732099..2732497) /gene="yugU" /locus_tag="BSU_31280" /old_locus_tag="BSU31280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391006.2" /db_xref="EnsemblGenomes-Gn:BSU31280" /db_xref="EnsemblGenomes-Tr:CAB15106" /db_xref="InterPro:IPR001602" /db_xref="InterPro:IPR035917" /db_xref="SubtiList:BG12373" /db_xref="UniProtKB/Swiss-Prot:O05243" /translation="MLKTLQIKTTKRDEMIDITREVEAFLQETGITSGAALIYCPHTT AGITINENADPDVKKDMLRRFDEVYPWEHELDRHMEGNTAAHMKSSTVGASQHVIVEN GRLILGTWQGIYFCEFDGPRTRTCYIKMMG*" /label="yugU CDS" gene complement(2732099..2732497) /gene="yugU" /locus_tag="BSU_31280" /old_locus_tag="BSU31280" /label="yugU gene" CDS complement(2732457..2732591) /locus_tag="BSU_31289" /old_locus_tag="BSU31289" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514000.1" /translation="MFYRVYESGLTGKKRTQNELSDESGQTKGETNAENTANQNNQTR *" /label="hypothetical protein CDS" gene complement(2732457..2732591) /locus_tag="BSU_31289" /old_locus_tag="BSU31289" /label="gene" promotor_-10 complement(2732540..2732559) /Source="Nicolas_upshift_promotors" /id="U2430" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=145 /SigmaFactorBS="ttagactggagtttttttgttttatcgGGTTTATgagagcgg tttaacAGGAAAAAAAAGAACACAGAacgaattaagcgatgagagcggacaaacgaaa g" /listShort="yugU, S1192, yuzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2732547) /Source="Nicolas_upshifts" /id="U2430" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=145 /SigmaFactorBS="ttagactggagtttttttgttttatcgGGTTTATgagagcgg tttaacAGGAAAAAAAAGAACACAGAacgaattaagcgatgagagcggacaaacgaaa g" /listShort="yugU, S1192, yuzH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2732574..2732580) /Source="Nicolas_upshift_promotors" /id="U2430" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=145 /SigmaFactorBS="ttagactggagtttttttgttttatcgGGTTTATgagagcgg tttaacAGGAAAAAAAAGAACACAGAacgaattaagcgatgagagcggacaaacgaaa g" /listShort="yugU, S1192, yuzH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2732617..2734281) /gene="yugT" /locus_tag="BSU_31290" /old_locus_tag="BSU31290" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1761534; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oligo-1,6-glucosidase" /protein_id="NP_391007.2" /db_xref="EnsemblGenomes-Gn:BSU31290" /db_xref="EnsemblGenomes-Tr:CAB15118" /db_xref="GOA:O05242" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="SubtiList:BG12372" /db_xref="UniProtKB/Swiss-Prot:O05242" /translation="MKKAWWKEAVVYQIYPRSFKDSNGDGIGDIQGIRTKLSYIKELG ADVIWICPLYDSPNADNGYDIRDYQNILSEFGTMEDFDELLGDIHDLDMKLIMDLVVN HTSDEHPWFIESRSSIHSEKRDWYIWKDGKNGKTPNNWESIFGGPAWEYDQKTSQYYL HLFDKKQPDLNWENEKVRNAVYDMINWWLDKGIDGFRVDAITHIKKKEGFPDMPNPKG LDYVPSFPYHMNADGIMDLLTELKENTFSRYPIMTVGEANGVAAKEAADWAGEKNGIF SMIFQFEHLGLWDVEINESIDIVAFKRILTDWQDSLEGIGWNALFMENHDQPRSVSVW GDDGVYLKESAKALSAVYFLMKGTPFIYQGQELGMTNVAFPSIEDYDDVALKRLYETK TAKGTSHEDVMKIVWKKGRDNSRTPMQWNAGPYAGFSEAKPWIGINENYKWLNAEAQK NDKTSVYHFYKSLIKLRQTYDVFINGTYELILPEDQQIFAYLRKNESHTALIAANLTG TPALFRHSGLPLSSDALVLSNIETEPHKHMTSVLLKPYEARIYLWC*" /label="yugT CDS" gene complement(2732617..2734281) /gene="yugT" /locus_tag="BSU_31290" /old_locus_tag="BSU31290" /label="yugT gene" downshifts complement(2732633) /Source="Nicolas_upshifts" /id="D1621" /incds=0 /nref=13 /ntot=38 /MaxReadThrough="1.79723" /MaxDrop="4.64379" /score="19.4176812" /energy="-6.5" /TU="NA" /idTUdmin="U2432" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2733589..2733608) /Source="Nicolas_upshift_promotors" /id="U2431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.993006993006993" /xcortree=2467 /SigmaFactorBS="tttcctgacatgccgaatccaaaggGACTGGACtatgtccct tcctTTCCTTATCATATGAATGCTgacggcattatggatttgttaacagagctgaagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2733594) /Source="Nicolas_upshifts" /id="U2431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.993006993006993" /xcortree=2467 /SigmaFactorBS="tttcctgacatgccgaatccaaaggGACTGGACtatgtccct tcctTTCCTTATCATATGAATGCTgacggcattatggatttgttaacagagctgaagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2733622..2733629) /Source="Nicolas_upshift_promotors" /id="U2431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.993006993006993" /xcortree=2467 /SigmaFactorBS="tttcctgacatgccgaatccaaaggGACTGGACtatgtccct tcctTTCCTTATCATATGAATGCTgacggcattatggatttgttaacagagctgaagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2734306..2734324) /Source="Nicolas_upshift_promotors" /id="U2432" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1123 /SigmaFactorBS="gctgttttttgtgtcatcaagtcatttcttaaaaagcaATGC TGtaaagacctttttctACATAGGATATATAAGAACggtacactgggaaggagtggct g" /listShort="yugT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2734323) /Source="Nicolas_upshifts" /id="U2432" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1123 /SigmaFactorBS="gctgttttttgtgtcatcaagtcatttcttaaaaagcaATGC TGtaaagacctttttctACATAGGATATATAAGAACggtacactgggaaggagtggct g" /listShort="yugT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2734340..2734345) /Source="Nicolas_upshift_promotors" /id="U2432" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1123 /SigmaFactorBS="gctgttttttgtgtcatcaagtcatttcttaaaaagcaATGC TGtaaagacctttttctACATAGGATATATAAGAACggtacactgggaaggagtggct g" /listShort="yugT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2734408..2735697) /gene="yugS" /locus_tag="BSU_31300" /old_locus_tag="BSU31300" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_391008.2" /db_xref="EnsemblGenomes-Gn:BSU31300" /db_xref="EnsemblGenomes-Tr:CAB15119" /db_xref="GOA:O05241" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12371" /db_xref="UniProtKB/Swiss-Prot:O05241" /translation="MLILQLIAIFVLIGITAVFVAAEFAIVKIRGSKINQLIESGDSR ALAAHKIISNLDEYLSACQLGITITALGLGWLGEPTFERFLHPLFTMTGIPEPFNHIV TFVVAFIIVTFLHVVMGELAPKTVSIQKAEAVSLWIAKPLIWFYKITYPFIKALNGSA SFLVKLFGFHSVKEHQVVISEEELRLILSESYEKGEINQSEFRYVNKIFEFDNRVARE IMIPRTEIAVISLEQSLEEAIHHIINERYTRYPVIKDDKDHILGIINSKDMFKAYFLG QPIKLNQIMRPVIRVIESIPVQQLLIRMQKERIHMAILVDEYGGTAGLVTVEDIIEEI VGEIRDEYDQDETPHILKKGEHHYVMDGKALIDEVNDLLDIAIENEEIDTIAGWLLTQ KMELKAGDVIHAEGCEFKILDAEDHHIRFVEIKKTDF*" /label="yugS CDS" gene complement(2734408..2735697) /gene="yugS" /locus_tag="BSU_31300" /old_locus_tag="BSU31300" /label="yugS gene" downshifts complement(2734417) /Source="Nicolas_upshifts" /id="D1622" /incds=0 /nref=5 /ntot=28 /MaxReadThrough="0.89237" /MaxDrop="3.67001" /score="3.60520478" /energy="-7.6" /TU="NA" /idTUdmin="U2434" /TUdmin=13 /isTUend="TRUE" /label="downshifts" promotor_-35 2735226..2735232 /Source="Nicolas_upshift_promotors" /id="U2433" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=254 /SigmaFactorBS="aagccaaacaatttcacaagaaaacttgcagagcCGTTTAAt gctttaataaacGGGTACGTGATTTTATAAAaccagatcagcggctttgcaatccata a" /listShort="S1193" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2735246..2735264 /Source="Nicolas_upshift_promotors" /id="U2433" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=254 /SigmaFactorBS="aagccaaacaatttcacaagaaaacttgcagagcCGTTTAAt gctttaataaacGGGTACGTGATTTTATAAAaccagatcagcggctttgcaatccata a" /listShort="S1193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2735252 /Source="Nicolas_upshifts" /id="U2433" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=254 /SigmaFactorBS="aagccaaacaatttcacaagaaaacttgcagagcCGTTTAAt gctttaataaacGGGTACGTGATTTTATAAAaccagatcagcggctttgcaatccata a" /listShort="S1193" /GFF_Attribute="listLong" /label="upshifts" S_feature 2735256..2735908 /Source="Nicolas_S_feature" /locus_tag="new_3217011_3217663" /HighExp="Etha, Sw, Gly, Salt, BC, B60, Heat, S8, B36, HiTm" /AntisenseName="yugS" /AntisenseCor="0.12310225183111501" /AntisenseRegPval="-1.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1193" CDS complement(2735741..2736418) /gene="yugP" /locus_tag="BSU_31310" /old_locus_tag="BSU31310" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16704729, 16850406, 24383880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent protease/peptidase" /protein_id="NP_391009.1" /db_xref="EnsemblGenomes-Gn:BSU31310" /db_xref="EnsemblGenomes-Tr:CAB15120" /db_xref="GOA:O05248" /db_xref="InterPro:IPR007395" /db_xref="SubtiList:BG12370" /db_xref="UniProtKB/Swiss-Prot:O05248" /translation="MLFIFLTIAALGLSFWAQFKVKSNFEKYSKVEASSGRTGAETAR RILDINGLYDVPVEPVRGTLTDHYDPTRRVVRLSEPVYYGRSISAISVASHEVGHALQ HQESYGALVLRHKIFPVVNFASGVAPLLFLGGMLLGSLNLIGLGIILFSAAVFFQLIT LPVEFNASSRAKQIIVSEGFIRNNEENGVNKVLSAAALTYVAAALVSLFELLRFVMIF LNGRDEN*" /label="yugP CDS" gene complement(2735741..2736418) /gene="yugP" /locus_tag="BSU_31310" /old_locus_tag="BSU31310" /label="yugP gene" downshifts complement(2735751) /Source="Nicolas_upshifts" /id="D1623" /incds=0 /nref=153 /ntot=249 /MaxReadThrough="3.51629" /MaxDrop="4.854" /score="33.0420688" /energy="-13" /TU="U2434,U2435" /idTUdmin="U2435" /TUdmin="-243" /isTUend="FALSE" /label="downshifts" S_feature 2736093..2736769 /Source="Nicolas_S_feature" /locus_tag="new_3217848_3218524" /HighExp="Sw, S8, Salt, BC, S7, Etha, Gly, B36, B60, LPhT" /AntisenseName="yuzI" /AntisenseCor="0.20035821815170399" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1194" promotor_-10 complement(2736453..2736472) /Source="Nicolas_upshift_promotors" /id="U2434" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=2033 /SigmaFactorBS="ctgattggattgtgtgctccaagccggaagaaaaagcgcatT TCTGTACacgagaaagaaaaCTCATTAAAATAATCGTAATagagaaatgatcatgaac a" /listShort="yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2736460..2736723) /gene="yuzI" /locus_tag="BSU_31319" /old_locus_tag="BSU31319" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16704729; Product type f : factor" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097777.1" /db_xref="EnsemblGenomes-Gn:BSU31319" /db_xref="EnsemblGenomes-Tr:CAX52683" /db_xref="GOA:C0H3Q4" /db_xref="UniProtKB/Swiss-Prot:C0H3Q4" /translation="MTIFQRTIVVLIGTQLAASAVILFIFDLNSYNHFSGSFSWLHFL KELAGSFAFYLFSAGLFFLLIGLCAPSRKKKRISVHEKENSLK*" /label="yuzI CDS" gene complement(2736460..2736723) /gene="yuzI" /locus_tag="BSU_31319" /old_locus_tag="BSU31319" /label="yuzI gene" upshifts complement(2736474) /Source="Nicolas_upshifts" /id="U2434" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=2033 /SigmaFactorBS="ctgattggattgtgtgctccaagccggaagaaaaagcgcatT TCTGTACacgagaaagaaaaCTCATTAAAATAATCGTAATagagaaatgatcatgaac a" /listShort="yugP, yugS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2736486..2736493) /Source="Nicolas_upshift_promotors" /id="U2434" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=2033 /SigmaFactorBS="ctgattggattgtgtgctccaagccggaagaaaaagcgcatT TCTGTACacgagaaagaaaaCTCATTAAAATAATCGTAATagagaaatgatcatgaac a" /listShort="yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2736735..2736753) /Source="Nicolas_upshift_promotors" /id="U2435" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1079 /SigmaFactorBS="cccacttccggtgatgtttttcaaaaaatgtacaaAACATAt aaaaccggatttctCCATAAACTAAAACAAAAAggatgaaaaagatgacgatctttca a" /listShort="yuzI, yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2736749) /Source="Nicolas_upshifts" /id="U2435" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1079 /SigmaFactorBS="cccacttccggtgatgtttttcaaaaaatgtacaaAACATAt aaaaccggatttctCCATAAACTAAAACAAAAAggatgaaaaagatgacgatctttca a" /listShort="yuzI, yugP, yugS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2736769..2736774) /Source="Nicolas_upshift_promotors" /id="U2435" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1079 /SigmaFactorBS="cccacttccggtgatgtttttcaaaaaatgtacaaAACATAt aaaaccggatttctCCATAAACTAAAACAAAAAggatgaaaaagatgacgatctttca a" /listShort="yuzI, yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2736770..2737102 /gene="mstX" /locus_tag="BSU_31321" /old_locus_tag="BSU31321" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15731457, 23737939, 25297828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15731457, 23737939, 25297828; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="atypical membrane-integrating regulator of biofilm formation (Mistic protein)" /protein_id="YP_003097778.1" /db_xref="EnsemblGenomes-Gn:BSU31321" /db_xref="EnsemblGenomes-Tr:CAX52684" /db_xref="GOA:Q5BU39" /db_xref="InterPro:IPR021078" /db_xref="PDB:1YGM" /db_xref="UniProtKB/Swiss-Prot:Q5BU39" /translation="MFCTFFEKHHRKWDILLEKSTGVMEAMKVTSEEKEQLSTAIDRM NEGLDAFIQLYNESEIDEPLIQLDDDTAELMKQARDMYGQEKLNEKLNTIIKQILSIS VSEEGEKE*" /label="mstX CDS" gene 2736770..2737102 /gene="mstX" /locus_tag="BSU_31321" /old_locus_tag="BSU31321" /label="mstX gene" promotor_-35 2736787..2736793 /Source="Nicolas_upshift_promotors" /id="U2436" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=1012 /SigmaFactorBS="tccggttttatatgttttgtacatttttTGAAAAAcatcacc ggaagtgGGACATACTGTTAGAAAAaagcacgggtgtgatggaagctatgaaagtgac g" /listShort="mstX, yugO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2736808..2736825 /Source="Nicolas_upshift_promotors" /id="U2436" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=1012 /SigmaFactorBS="tccggttttatatgttttgtacatttttTGAAAAAcatcacc ggaagtgGGACATACTGTTAGAAAAaagcacgggtgtgatggaagctatgaaagtgac g" /listShort="mstX, yugO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2736819 /Source="Nicolas_upshifts" /id="U2436" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=1012 /SigmaFactorBS="tccggttttatatgttttgtacatttttTGAAAAAcatcacc ggaagtgGGACATACTGTTAGAAAAaagcacgggtgtgatggaagctatgaaagtgac g" /listShort="mstX, yugO" /GFF_Attribute="listLong" /label="upshifts" CDS 2737099..2738085 /gene="kbfO" /locus_tag="BSU_31322" /old_locus_tag="BSU31322" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16704729, 23737939, 25297828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16704729, 23737939, 25297828; Product type t: transporter" /codon_start=1 /transl_table=11 /product="potassium channel protein involved in biofilm formation" /protein_id="NP_391010.3" /db_xref="EnsemblGenomes-Gn:BSU31322" /db_xref="EnsemblGenomes-Tr:CAB15121" /db_xref="GOA:Q795M8" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR013099" /db_xref="InterPro:IPR028325" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12369" /db_xref="UniProtKB/Swiss-Prot:Q795M8" /translation="MKSNRIFISWLRWPLFIRIGVIILCLILLFGQIIYILEPKQFTS VFEGIWWAVVTVSTVGYGDYVPHTPLGQAAGILLILSGASFVTAYFATLSAAAFSRQH RYIEGKVAYKGRDHIILIGWNEKTNRLLKDLQLAAPSKTVVLIDESLTEGPLIENVHF IRGHAADDGTLKRANITEAESVMITADQYKSETDADMLSVLTLLSVKGLNPLAYCIVE ILTDRFVTNAERAGANQIIGTSEFISRAMLQHYQVKLRPSKQQNGIKLTLDQHVELLA VPDELKGAAYKTCVLYFLDHNTTIIGIQKKEGPMLSPPLTYKVLETDQFLAI*" /label="kbfO CDS" gene 2737099..2738085 /gene="kbfO" /locus_tag="BSU_31322" /old_locus_tag="BSU31322" /label="kbfO gene" downshifts complement(2738060) /Source="Nicolas_upshifts" /id="D1624" /incds=0 /nref=44 /ntot=128 /MaxReadThrough="0.617940000000001" /MaxDrop="4.76695" /score="21.5904825" /energy="-11.3" /TU="NA" /idTUdmin="U2437" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2738082..2738486) /gene="yugN" /locus_tag="BSU_31330" /old_locus_tag="BSU31330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391011.1" /db_xref="EnsemblGenomes-Gn:BSU31330" /db_xref="EnsemblGenomes-Tr:CAB15122" /db_xref="InterPro:IPR014967" /db_xref="InterPro:IPR036491" /db_xref="SubtiList:BG12368" /db_xref="UniProtKB/Swiss-Prot:O05246" /translation="MIPIPSAIDGQSFLLQELEQVMKPLGYVINGGWEYDHGYFDYKI DDRDGYLFLRIPVNAVQGSLDERGAAVRIGTPFMLRQVFQADVDDHAEGGPFQSLFNQ FSEPERRDAEIDPAFLDIGASLVKELEDVLLH*" /label="yugN CDS" gene complement(2738082..2738486) /gene="yugN" /locus_tag="BSU_31330" /old_locus_tag="BSU31330" /label="yugN gene" S_feature complement(2738487..2738545) /Source="Nicolas_S_feature" /locus_tag="new_3220242_3220300_c" /HighExp="M0t90, M40t90, S6, S8, S7, T0.30H, Lbstat, M9-stat, T1.30H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, Sig-, SigA" /TUshortPSig="0.686, 0.141, 0.984" /TUlongSig="SigA" /TUlongPSig="0.988" /label="S1195" CDS complement(2738546..2738917) /gene="yugM" /locus_tag="BSU_31340" /old_locus_tag="BSU31340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391012.1" /db_xref="EnsemblGenomes-Gn:BSU31340" /db_xref="EnsemblGenomes-Tr:CAB15123" /db_xref="GOA:O05245" /db_xref="SubtiList:BG12367" /db_xref="UniProtKB/Swiss-Prot:O05245" /translation="MFMKQLVKHLIIAGFSAAILSFLISFDAVYTGFSSSFGGTLSHF FIHSFLLIGLPLALFTDAVHRILHLKRTHTLFTKLGLYATVVYVSWDSAVWLAAAMAV YFLIECAFFPVGRAKETTISM*" /label="yugM CDS" gene complement(2738546..2738917) /gene="yugM" /locus_tag="BSU_31340" /old_locus_tag="BSU31340" /label="yugM gene" CDS complement(2738976..2740328) /gene="pgi" /locus_tag="BSU_31350" /old_locus_tag="BSU31350" /EC_number="5.3.1.9" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 4214896, 4275311, 11489127, 19052382, 21453533, 22720735, 24705866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-6-phosphate isomerase" /protein_id="NP_391013.2" /db_xref="EnsemblGenomes-Gn:BSU31350" /db_xref="EnsemblGenomes-Tr:CAB15124" /db_xref="GOA:P80860" /db_xref="InterPro:IPR001672" /db_xref="InterPro:IPR018189" /db_xref="InterPro:IPR035476" /db_xref="InterPro:IPR035482" /db_xref="SubtiList:BG12366" /db_xref="UniProtKB/Swiss-Prot:P80860" /translation="MTHVRFDYSKALTFFNEHELTYLRDFVKTAHHNIHEKTGAGSDF LGWVDLPEHYDKEEFARIKKSAEKIKSDSDVLLVVGIGGSYLGARAAIEALNHAFYNT LPKAKRGNPQVIFIGNNISSSYMRDVMDLLEDVDFSINVISKSGTTTEPAIAFRIFRK LLEEKYGKEEAKARIYATTDKERGALKTLSNEEGFESFVIPDDVGGRYSVLTAVGLLP IAVSGVNIDDMMKGALDASKDFATSELEDNPAYQYAVVRNVLYNKGKTIEMLINYEPA LQYFAEWWKQLFGESEGKDEKGIYPSSANYSTDLHSLGQYVQEGRRDLFETVLNVEKP KHELTIEEADNDLDGLNYLAGKTVDFVNKKAFQGTMLAHTDGNVPNLIVNIPELNAYT FGYLVYFFEKACAMSGYLLGVNPFDQPGVEAYKVNMFALLGKPGFEEKKAELEKRLED *" /label="pgi CDS" gene complement(2738976..2740328) /gene="pgi" /locus_tag="BSU_31350" /old_locus_tag="BSU31350" /label="pgi gene" downshifts complement(2738987) /Source="Nicolas_upshifts" /id="D1625" /incds=0 /nref=90 /ntot=198 /MaxReadThrough="6.86736" /MaxDrop="4.4585" /score="24.139293" /energy="-16.8" /TU="U2437,U2438,U2439" /idTUdmin="U2441" /TUdmin=19 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2739143..2739161) /Source="Nicolas_upshift_promotors" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2739160) /Source="Nicolas_upshifts" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2739177..2739182) /Source="Nicolas_upshift_promotors" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2740301) /Source="Nicolas_upshifts" /id="U2438" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.325674325674326" /psig="0.140859140859141" /xcortree=1777 /SigmaFactorBS="tgaaaacattataccgttatggagggacaagcaatgacgcat gtacGCTTTGACTACTcaaaagcgttgactttcttcaacgaacatgaacttacatacc t" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2740304..2740315) /Source="Nicolas_upshift_promotors" /id="U2438" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.325674325674326" /psig="0.140859140859141" /xcortree=1777 /SigmaFactorBS="tgaaaacattataccgttatggagggacaagcaatgacgcat gtacGCTTTGACTACTcaaaagcgttgactttcttcaacgaacatgaacttacatacc t" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2740360..2740379) /Source="Nicolas_upshift_promotors" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2740366) /Source="Nicolas_upshifts" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2740368..2740439) /Source="Nicolas_S_feature" /locus_tag="new_3222123_3222194_c" /HighExp="Etha, H2O2, Paraq, Oxctl, G180, G150, dia5, dia15, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.988" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1196" promotor_-35 complement(2740394..2740397) /Source="Nicolas_upshift_promotors" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2740440..2741612) /gene="bdhK" /locus_tag="BSU_31360" /old_locus_tag="BSU31360" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1385386, 1809209, 2673038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH-dependent butanol dehydrogenase subunit" /protein_id="NP_391014.1" /db_xref="EnsemblGenomes-Gn:BSU31360" /db_xref="EnsemblGenomes-Tr:CAB15125" /db_xref="GOA:O05240" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG12365" /db_xref="UniProtKB/Swiss-Prot:O05240" /translation="MENFTYYNPTKLIFGKGQLEQLRKEFKRYGKNVLLVYGGGSIKR NGLYDQVTGILKEEGAVVHELSGVEPNPRLATVEKGIGLCREHDIDFLLAVGGGSVID CTKAIAAGVKYDGDAWDIFSKKVTAEDALPFGTVLTLAATGSEMNPDSVITNWETNEK FVWGSNVTHPRFSILDPENTFTVPENQTVYGMVDMMSHVFEQYFHNVENTPLQDRMCF AVLQTVIETAPKLLEDLENYELRETILYAGTIALNGTLQMGYFGDWASHTMEHAVSAV YDIPHAGGLAILFPNWMRYTLDTNVGRFKNLMLNMFDIDTEGKTDKEIALEGIDKLSA FWTSLGAPSRLADYNIGEEKLELIADIAAKEMEHGGFGNFQKLNKDDVLAILRASL*" /label="bdhK CDS" gene complement(2740440..2741612) /gene="bdhK" /locus_tag="BSU_31360" /old_locus_tag="BSU31360" /label="bdhK gene" S_feature 2740775..2741696 /Source="Nicolas_S_feature" /locus_tag="new_3222530_3223451" /HighExp="S6, S7, S8, BT, S5, C30, LBGstat, B36, G135, G150" /AntisenseName="yugK" /AntisenseCor="4.31382473780575E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1197" promotor_-10 complement(2741645..2741664) /Source="Nicolas_upshift_promotors" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="promotor_-10" upshifts complement(2741658) /Source="Nicolas_upshifts" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="upshifts" promotor_-35 complement(2741681..2741684) /Source="Nicolas_upshift_promotors" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="promotor_-35" CDS complement(2741716..2742879) /gene="bdhJ" /locus_tag="BSU_31370" /old_locus_tag="BSU31370" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1385386, 2673038, 9643546, 11466286, 15317791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH-dependent butanol dehydrogenase" /protein_id="NP_391015.1" /db_xref="EnsemblGenomes-Gn:BSU31370" /db_xref="EnsemblGenomes-Tr:CAB15126" /db_xref="GOA:O05239" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG12364" /db_xref="UniProtKB/Swiss-Prot:O05239" /translation="MQNFTYWNPTKLIFGRGEVERLPEELKPYGKNVLLVYGGGSIKR SGLYDQVIEQLNKAGATVHELAGVEPNPRVSTVNKGVAICKEQNIDFLLAVGGGSVID CTKAIAAGAKYDGDAWDIVTKKHQPKDALPFGTVLTLAATGSEMNSGSVITNWETKEK YGWGSPLVFPKFSILDPVNTFTVPKNHTIYGMVDMMSHVFEQYFHHVSNTPYQDRMCE SLLRTVIETAPKLINDLENYELRETILYTGTIALNGMLSMGARGDWATHNIEHAVSAV YDIPHAGGLAILFPNWMRHTLSENPARMKQLAVRVFDVEEAGKTDEEIALEGIDKLSA FWTSLGAPNRLADYDINDEQLDTIADKAMANGTFGQFKSLNKEDVLSILKASL*" /label="bdhJ CDS" gene complement(2741716..2742879) /gene="bdhJ" /locus_tag="BSU_31370" /old_locus_tag="BSU31370" /label="bdhJ gene" downshifts complement(2741731) /Source="Nicolas_upshifts" /id="D1626" /incds=0 /nref=167 /ntot=237 /MaxReadThrough="6.69366" /MaxDrop="4.74696" /score="28.8200012" /energy="-13.4" /TU="U2441" /idTUdmin="U2444" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2742894..2742913) /Source="Nicolas_upshift_promotors" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="promotor_-10" upshifts complement(2742912) /Source="Nicolas_upshifts" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="upshifts" S_feature complement(2742914..2743069) /Source="Nicolas_S_feature" /locus_tag="new_3224669_3224824_c" /HighExp="S8, S7, S4, S5, S6, LoTm, Cold, LBGtran, G180, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25658199999999998" /TUshortSig="SigGF, SigA" /TUshortPSig="0.679, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1198" promotor_-35 complement(2742928..2742935) /Source="Nicolas_upshift_promotors" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="promotor_-35" promotor_-35 2742965..2742971 /Source="Nicolas_upshift_promotors" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2742986..2743004 /Source="Nicolas_upshift_promotors" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2742996 /Source="Nicolas_upshifts" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="upshifts" S_feature 2742997..2743055 /Source="Nicolas_S_feature" /locus_tag="new_3224752_3224810" /HighExp="Etha, Salt, Heat, M9-stat, LPhT, Sw, Gly, BC, HiTm, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1199" promotor_-35 2743042..2743048 /Source="Nicolas_upshift_promotors" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2743044..2743055) /Source="Nicolas_upshift_promotors" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2743057 /Source="Nicolas_upshifts" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2743062..2743073 /Source="Nicolas_upshift_promotors" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2743069..2743075) /Source="Nicolas_upshift_promotors" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2743069) /Source="Nicolas_upshifts" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2743071..2743382) /Source="Nicolas_S_feature" /locus_tag="new_3224826_3225137_c" /HighExp="Cold, LBGtran, LoTm, G180, LBGexp, dia15, G135, H2O2, Paraq, Oxctl" /AntisenseName="yuzA" /AntisenseCor="-0.50065532030853999" /AntisenseRegPval="-17.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1200" CDS 2743109..2743345 /gene="yuzA" /locus_tag="BSU_31380" /old_locus_tag="BSU31380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391016.1" /db_xref="EnsemblGenomes-Gn:BSU31380" /db_xref="EnsemblGenomes-Tr:CAB15127" /db_xref="GOA:O32087" /db_xref="InterPro:IPR007211" /db_xref="SubtiList:BG14050" /db_xref="UniProtKB/Swiss-Prot:O32087" /translation="MSTIQRICLVLTIIGAINWGLIGFFQFDLVAAIFGGQGSALSRI IYGLVGIAGLINLGLLFKPNEERSREEAANPEMR*" /label="yuzA CDS" gene 2743109..2743345 /gene="yuzA" /locus_tag="BSU_31380" /old_locus_tag="BSU31380" /label="yuzA gene" downshifts 2743305 /Source="Nicolas_upshifts" /id="D1627" /incds=0 /nref=3 /ntot=45 /MaxReadThrough="7.39676" /MaxDrop="2.87922" /score="13.9936296" /energy="-12" /TU="U2442,U2443" /idTUdmin="U2442" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 2743371 /Source="Nicolas_upshifts" /id="D1628" /incds=0 /nref=25 /ntot=56 /MaxReadThrough="1.29261" /MaxDrop="7.50276" /score="13.9936296" /energy="-12" /TU="NA" /idTUdmin="U2442" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2743423..2743815) /gene="yugI" /locus_tag="BSU_31390" /old_locus_tag="BSU31390" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9862121, 16014871, 19152054, 19636895; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA degradation protein; putative phosphorylase or nucleotidyl transferase; general stress protein" /protein_id="NP_391017.1" /db_xref="EnsemblGenomes-Gn:BSU31390" /db_xref="EnsemblGenomes-Tr:CAB15128" /db_xref="GOA:P80870" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="PDB:2K4K" /db_xref="SubtiList:BG12363" /db_xref="UniProtKB/Swiss-Prot:P80870" /translation="MAAKFEVGSVYTGKVTGLQAYGAFVALDEETQGLVHISEVTHGF VKDINEHLSVGDEVQVKVLAVDEEKGKISLSIRATQAAPEKKESKPRKPKAAQVSEEA STPQGFNTLKDKLEEWIEMSNRKDLIKK*" /label="yugI CDS" gene complement(2743423..2743815) /gene="yugI" /locus_tag="BSU_31390" /old_locus_tag="BSU31390" /label="yugI gene" downshifts complement(2743427) /Source="Nicolas_upshifts" /id="D1629" /incds=0 /nref=232 /ntot=268 /MaxReadThrough="5.9665" /MaxDrop="6.0195" /score="13.5952751" /energy="-15.6" /TU="U2445" /idTUdmin="U2448" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2743857..2743876) /Source="Nicolas_upshift_promotors" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="promotor_-10" upshifts complement(2743864) /Source="Nicolas_upshifts" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="upshifts" S_feature complement(2743866..2744016) /Source="Nicolas_S_feature" /locus_tag="new_3225621_3225771_c" /HighExp="G180, C30, G135, LBGexp, G150, Oxctl, HPh, Cold, BMM, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1201" promotor_-35 complement(2743892..2743896) /Source="Nicolas_upshift_promotors" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="promotor_-35" promotor_-35 2743919..2743925 /Source="Nicolas_upshift_promotors" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2743932..2744916 /Source="Nicolas_S_feature" /locus_tag="new_3225687_3226671" /HighExp="LoTm, C30, Salt, S7, S5, S8, Sw, S3, C90, S6" /AntisenseName="yugH" /AntisenseCor="-0.45629591209076698" /AntisenseRegPval="-14.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.662" /TUlongSig="NA" /TUlongPSig="NA" /label="S1202" upshifts 2743932 /Source="Nicolas_upshifts" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2743940..2743958 /Source="Nicolas_upshift_promotors" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2744017..2745177) /gene="yugH" /locus_tag="BSU_31400" /old_locus_tag="BSU31400" /EC_number="2.6.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12670965; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aspartate aminotransferase" /protein_id="NP_391018.2" /db_xref="EnsemblGenomes-Gn:BSU31400" /db_xref="EnsemblGenomes-Tr:CAB15129" /db_xref="GOA:Q795M6" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12362" /db_xref="UniProtKB/Swiss-Prot:Q795M6" /translation="MTSYLSDYVQQIKPSGIRKFFDLAATMEGVISLGVGEPDFVTAW NVREASILSLEQGYTSYTANAGLYSLREEISRYLSNRFDLSYSPDNELIVTVGASQAL DIAIRAIVNPGEEVIIPEPCFVAYDALVSLAGGIPVHVHTTADKGFKATAADFEAAVT EKTKAILICSPSNPTGSVYSKEELNEIAEFAKKHDVIVLADEIYAELTYDEEFTSIAA LPGMKERTVVISGFSKAFAMTGWRLGFAAAPSLLRDAMLKIHQYAMMCAPAMAQFAAL EGLKNGMEDVEKMKKSYRRRRNLFVESLNEIGLSCHHPGGAFYAFPSIKSMGMSSEQF AEELLTQEKVAVVPGSVFGPSGEGYIRCSYATSIEQLQEALVRMKRFLHKTT*" /label="yugH CDS" gene complement(2744017..2745177) /gene="yugH" /locus_tag="BSU_31400" /old_locus_tag="BSU31400" /label="yugH gene" promotor_-35 2745069..2745075 /Source="Nicolas_upshift_promotors" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2745087 /Source="Nicolas_upshifts" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2745089..2745093 /Source="Nicolas_upshift_promotors" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2745178..2745678) /gene="yugG" /locus_tag="BSU_31410" /old_locus_tag="BSU31410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_391019.1" /db_xref="EnsemblGenomes-Gn:BSU31410" /db_xref="EnsemblGenomes-Tr:CAB15130" /db_xref="GOA:O05236" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12361" /db_xref="UniProtKB/Swiss-Prot:O05236" /translation="MKLTEKETEILEILDENSRADLETIAKMAGIPVNEVKTIIDKLE KEKVIIDYSAMIDWRKVDGHEGVTAMIDVKVTPKRGVGFDEVAERIYRFQEVESVYLM SGVYDLSVVIRGNSMSDVARFVSDKLSTLDSVVSTTTHFILKKYKHDGKVFETGDDDK RIVVSP*" /label="yugG CDS" gene complement(2745178..2745678) /gene="yugG" /locus_tag="BSU_31410" /old_locus_tag="BSU31410" /label="yugG gene" promotor_-10 complement(2745708..2745727) /Source="Nicolas_upshift_promotors" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="promotor_-10" promotor_-35 2745714..2745720 /Source="Nicolas_upshift_promotors" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2745729) /Source="Nicolas_upshifts" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="upshifts" promotor_-10 2745735..2745746 /Source="Nicolas_upshift_promotors" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2745735 /Source="Nicolas_upshifts" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2745738..2745745) /Source="Nicolas_upshift_promotors" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="promotor_-35" S_feature 2745747..2745825 /Source="Nicolas_S_feature" /locus_tag="new_3227502_3227580" /HighExp="S8, S5, S6, S7, S4, C30, Glucon, Pyr, nit, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1203" CDS 2745826..2746647 /gene="yugF" /locus_tag="BSU_31420" /old_locus_tag="BSU31420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391020.1" /db_xref="EnsemblGenomes-Gn:BSU31420" /db_xref="EnsemblGenomes-Tr:CAB15131" /db_xref="GOA:O05235" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR013595" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12360" /db_xref="UniProtKB/Swiss-Prot:O05235" /translation="MEAVSPIRRFTVDGVNVYYEHYQNPGRQTLVCVHGFLSSAFSFR KVIPLLRDKYDIIALDLPPFGQSEKSRTFIYTYQNLAKLVIGILEHLQVKQAVLVGHS MGGQISLSAALQKPELFSKVVLLCSSGYLKRSHPTIIFGTHIPYFHLYIKRWLSKEGV MKNLLNVVHDKSLIDEEMIDGYGRPFQDEQIFKAMTRFIRHREGDLEPEQLKKMNKPA LLIWGEEDRIVPMEIGKRLHADLPNSVLYSLGQTGHLVPEERPELISEHIADFIK*" /label="yugF CDS" gene 2745826..2746647 /gene="yugF" /locus_tag="BSU_31420" /old_locus_tag="BSU31420" /label="yugF gene" downshifts 2746627 /Source="Nicolas_upshifts" /id="D1630" /incds=0 /nref=1 /ntot=12 /MaxReadThrough="1.0929" /MaxDrop="3.08755" /score="11.2614618" /energy="-6.6" /TU="NA" /idTUdmin="U2449" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2746674) /Source="Nicolas_upshifts" /id="D1631" /incds=0 /nref=20 /ntot=156 /MaxReadThrough="2.22671" /MaxDrop="4.10906" /score="25.9859375" /energy="-6.6" /TU="NA" /idTUdmin="U2451" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(2746676..2746936) /gene="yugE" /locus_tag="BSU_31430" /old_locus_tag="BSU31430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391021.2" /db_xref="EnsemblGenomes-Gn:BSU31430" /db_xref="EnsemblGenomes-Tr:CAB15132" /db_xref="InterPro:IPR015053" /db_xref="InterPro:IPR023162" /db_xref="SubtiList:BG12359" /db_xref="UniProtKB/Swiss-Prot:O05234" /translation="MEESHAVREMIKIIAKWDPFKYGEEFYETEAVDVVQAVYDENDP DLLAKSIQQIFETSFEQTLPIASCREVAGQLLFIKNSSSCTP*" /label="yugE CDS" gene complement(2746676..2746936) /gene="yugE" /locus_tag="BSU_31430" /old_locus_tag="BSU31430" /label="yugE gene" promotor_-35 2746926..2746929 /Source="Nicolas_upshift_promotors" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="promotor_-35" promotor_-10 2746944..2746963 /Source="Nicolas_upshift_promotors" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="promotor_-10" upshifts 2746956 /Source="Nicolas_upshifts" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="upshifts" S_feature 2746957..2747022 /Source="Nicolas_S_feature" /locus_tag="new_3228712_3228777" /HighExp="dia15, dia5, Lbexp, dia0, LBGtran, G180, Diami, H2O2, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1204" promotor_-10 complement(2746962..2746981) /Source="Nicolas_upshift_promotors" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2746967) /Source="Nicolas_upshifts" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2746993..2746999) /Source="Nicolas_upshift_promotors" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2747023..2748186 /gene="patB" /locus_tag="BSU_31440" /old_locus_tag="BSU31440" /EC_number="4.4.1.1" /EC_number="4.4.1.13" /EC_number="4.4.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15760717, 26337367, 28895253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15760717, 26337367, 28895253; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous cystathionine / cystine beta-lyase /cysteine desulfhydrase" /protein_id="NP_391022.1" /db_xref="EnsemblGenomes-Gn:BSU31440" /db_xref="EnsemblGenomes-Tr:CAB15133" /db_xref="GOA:Q08432" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR027619" /db_xref="SubtiList:BG10744" /db_xref="UniProtKB/Swiss-Prot:Q08432" /translation="MNFDKREERLGTQSVKWDKTGELFGVTDALPMWVADMDFRAPEA ITEALKERLDHGIFGYTTPDQKTKDAVCGWMQNRHGWKVNPESITFSPGVVTALSMAV QAFTEPGDQVVVQPPVYTPFYHMVEKNGRHILHNPLLEKDGAYAIDFEDLETKLSDPS VTLFILCNPHNPSGRSWSREDLLKLGELCLEHGVTVVSDEIHSDLMLYGHKHTPFASL SDDFADISVTCAAPSKTFNIAGLQASAIIIPDRLKRAKFSASLQRNGLGGLNAFAVTA IEAAYSKGGPWLDELITYIEKNMNEAEAFLSTELPKVKMMKPDASYLIWLDFSAYGLS DAELQQRMLKKGKVILEPGTKYGPGGEGFMRLNAGCSLATLQDGLRRIKAALS*" /label="patB CDS" gene 2747023..2748186 /gene="patB" /locus_tag="BSU_31440" /old_locus_tag="BSU31440" /label="patB gene" promotor_-35 2748249..2748255 /Source="Nicolas_upshift_promotors" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2748267..2748286 /Source="Nicolas_upshift_promotors" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2748277 /Source="Nicolas_upshifts" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="upshifts" CDS 2748312..2749598 /gene="kinB" /locus_tag="BSU_31450" /old_locus_tag="BSU31450" /EC_number="2.7.13.3" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:9426145, 11069677, 15849754, 16850406, 26152584, 28583948" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9426145, 11069677, 15849754, 16850406, 26152584, 28583948; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="two-component sensor potassium-binding histidinekinase" /protein_id="NP_391023.2" /db_xref="EnsemblGenomes-Gn:BSU31450" /db_xref="EnsemblGenomes-Tr:CAB15134" /db_xref="GOA:Q08430" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10745" /db_xref="UniProtKB/Swiss-Prot:Q08430" /translation="MEILKDYLLHICFILFPILLYQVFWLGKPAILVPKINSGLVTLF ACGASVLCIIFPIHEMDYIQYGLQMIPVIICLFYISTASGLTVAASVLCFELLFYEPS AMFVFTLLPFLIIIPILFQKKWPFMSKAKKLLLSLLISCVEIFLFFASSWILSALNIL NFQKSGIFVYEAAVSGLFRSSVLLLSIYIIESIAENIALRSQLIHSEKMTIVSELAAS VAHEVRNPLTVVRGFVQLLFNDETLQNKSSADYKKLVLSELDRAQGIITNYLDMAKQQ LYEKEVFDLSALIKETSSLMVSYANYKSVTVEAETEPDLLIYGDATKLKQAVINLMKN SIEAVPHGKGMIHISAKRNGHTIMINITDNGVGMTDHQMQKLGEPYYSLKTNGTGLGL TVTFSIIEHHHGTISFNSSFQKGTTVTIKLPADLPH*" /label="kinB CDS" gene 2748312..2749598 /gene="kinB" /locus_tag="BSU_31450" /old_locus_tag="BSU31450" /label="kinB gene" S_feature complement(2749314..2750056) /Source="Nicolas_S_feature" /locus_tag="new_3231069_3231811_c" /HighExp="BT, S8, B36, S6, S7, S5, S3, S4, Cold, Pyr" /AntisenseName="kapB" /AntisenseCor="-0.71681066342113797" /AntisenseRegPval="-43" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigK" /TUshortPSig="0.709, 0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1205" promotor_-35 2749593..2749600 /Source="Nicolas_upshift_promotors" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2749614..2749633 /Source="Nicolas_upshift_promotors" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2749615 /Source="Nicolas_upshifts" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="upshifts" CDS 2749644..2750030 /gene="kapB" /locus_tag="BSU_31460" /old_locus_tag="BSU31460" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9426145, 23335417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9426145, 23335417; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for KinB signal transduction andactivation of the phosphorelay to sporulation" /protein_id="NP_391024.1" /db_xref="EnsemblGenomes-Gn:BSU31460" /db_xref="EnsemblGenomes-Tr:CAB15135" /db_xref="GOA:Q08429" /db_xref="InterPro:IPR014916" /db_xref="SubtiList:BG10746" /db_xref="UniProtKB/Swiss-Prot:Q08429" /translation="MSTFETGSIVKGFYKTGVYIGEITACRPQHYLVKVKAVLTHPAQ GDLHHPKQADVPFFHERKALAYGEQTNIPHHMVKPYDGEVPDYTESLREATAQMRAKL NEDGSEWAKRSLHNLDILEKEYFNRP*" /label="kapB CDS" gene 2749644..2750030 /gene="kapB" /locus_tag="BSU_31460" /old_locus_tag="BSU31460" /label="kapB gene" downshifts 2750012 /Source="Nicolas_upshifts" /id="D1632" /incds=0 /nref=209 /ntot=249 /MaxReadThrough="1.62013" /MaxDrop="5.57132" /score="1.97959632" /energy="-9.2" /TU="NA" /idTUdmin="U2452" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2750057..2750674) /gene="kapD" /locus_tag="BSU_31470" /old_locus_tag="BSU31470" /EC_number="3.1.-.-" /function="16.3: Control" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27188294; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exoribonuclease (3'-5')" /protein_id="NP_391025.1" /db_xref="EnsemblGenomes-Gn:BSU31470" /db_xref="EnsemblGenomes-Tr:CAB15136" /db_xref="GOA:O05231" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12358" /db_xref="UniProtKB/Swiss-Prot:O05231" /translation="MTTNSLLIIDFEFTMPDGKYSPQNFFPEIIEAGIVKSIDDEVVE TFSSYVRPKKFPKLTKRCKSFLKITQKQVDEGMRFEDFIRKLNELDPEKNSTIITWGN MDMKVLKQNCMFNHIPFPFKGEMRDLSLEYKNFFGDRTLTGLWKAAEEYGDSGTGTHH KALDDALTAYKLFKLVEQDKQYLEKPKPPTIGERIDLTELLKRAT*" /label="kapD CDS" gene complement(2750057..2750674) /gene="kapD" /locus_tag="BSU_31470" /old_locus_tag="BSU31470" /label="kapD gene" promotor_-10 complement(2750709..2750727) /Source="Nicolas_upshift_promotors" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2750726) /Source="Nicolas_upshifts" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2750728..2752816) /Source="Nicolas_S_feature" /locus_tag="new_3232483_3234571_c" /HighExp="S8, BT, B36, S7, S6, Pyr, C30, B60, S5, G135" /AntisenseName="yuxJ" /AntisenseCor="-0.168930816447634" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1206" promotor_-35 complement(2750742..2750747) /Source="Nicolas_upshift_promotors" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2750790..2750793 /Source="Nicolas_upshift_promotors" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="promotor_-35" promotor_-10 2750808..2750827 /Source="Nicolas_upshift_promotors" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="promotor_-10" upshifts 2750819 /Source="Nicolas_upshifts" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="upshifts" CDS 2750885..2752063 /gene="yuxJ" /locus_tag="BSU_31480" /old_locus_tag="BSU31480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter induced in acid stress" /protein_id="NP_391026.2" /db_xref="EnsemblGenomes-Gn:BSU31480" /db_xref="EnsemblGenomes-Tr:CAB15137" /db_xref="GOA:P40760" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10976" /db_xref="UniProtKB/Swiss-Prot:P40760" /translation="MWLANFFVSASTTMIVPFLSLYIETLSSFSNGFVQRWSGYVFGI TFLMAFLVSPFWGRFGDKRGYKKILMATGTGIALSIFFMGFVTSVYQLFFLRMAMGLV TGFIPTSLAMISAQTPKSSAGKTLGTLQMGQVSGSLFGPLLGGMLADRFGFTYTFFIT SFVIFSSVLLVLFGVKEKHLAEKTAKRTSYSRKEVLSYIFHHPALWVMMLLTMLIQTG NFSIQPLLALYVNELHGPVNLAFFSGMAFSATGLGSLLLARKWGDLGDRYGHRRILIG LLLAASFFFIPQALASSLSVLLVFRFLFGMAMGGLLPCITAAIRVQAPGSIQGEVLGY NVSFRFLGNVLGPLLGGIISSHFTISATFYVTAFLFFAGACMLWIMQKLRKDSYAKAS *" /label="yuxJ CDS" gene 2750885..2752063 /gene="yuxJ" /locus_tag="BSU_31480" /old_locus_tag="BSU31480" /label="yuxJ gene" promotor_-35 2752101..2752107 /Source="Nicolas_upshift_promotors" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2752119..2752138 /Source="Nicolas_upshift_promotors" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2752124 /Source="Nicolas_upshifts" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="upshifts" CDS 2752156..2754030 /gene="pbpD" /locus_tag="BSU_31490" /old_locus_tag="BSU31490" /EC_number="2.-.-.-" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7961491, 9274030; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 4" /protein_id="NP_391027.2" /db_xref="EnsemblGenomes-Gn:BSU31490" /db_xref="EnsemblGenomes-Tr:CAB15138" /db_xref="GOA:P40750" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10977" /db_xref="UniProtKB/Swiss-Prot:P40750" /translation="MTMLRKIIGWILLLCIIPLFAFTVIASGKEVKQMKSLDQVLDKN IDLKDISLVQNSYMYDRDGSLVSEIVSDHENRVLVPFNKIPEEVKQIFLTSEDRHFYE HKGFDFMGMVRATASNVKDKKIDQGASTITQQLSRNLYLSHERSFSRKLTELAYSYQL EKKYTKNEILEAYLNTIYFNNGVYGVGSAAQFYFSKPLKSLTVGEMAFICAIPNNPTL YDPLKHFDYTKSRQERLLKGLKDAGVITDKELKKAVKQKIKLDVEKREDKYPDYVSYV NDEFTQLVSESEGFDKRLQKASGKQKEKIENELSARVSTLMKDGVKIYTALDPYMQNQ VVAQMNSKLPYADVQGGAAVINHQTHQIIALSGGKNYQKYDFNRAYQAYRQPGSSIKP LLDYGPYIEQTGATTSSTIDASKFCSKDYCPQNYNNRTYGTVTLDTAFKNSYNTPAIR MLDRVGIQKAFSYIEPYHFAKLVDSDYLLPAALGGFTNGMTPLEMTKAYTTFGNSGSY TPSHAITKVTDLKGKTLYKWNDKATQIFSVRTNMQLKKLMSSVVKSGTGKKAYFNAPY IGGKTGTSNDYHDMWFVGLTDTYTMGVWVGKDTPTSVEYLHSISPQLSIWKGTLQAAY *" /label="pbpD CDS" gene 2752156..2754030 /gene="pbpD" /locus_tag="BSU_31490" /old_locus_tag="BSU31490" /label="pbpD gene" promotor_-10 complement(2752796..2752815) /Source="Nicolas_upshift_promotors" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2752816) /Source="Nicolas_upshifts" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2752829..2752838) /Source="Nicolas_upshift_promotors" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2754051..2754464 /gene="yuxK" /locus_tag="BSU_31500" /old_locus_tag="BSU31500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26335199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase" /protein_id="NP_391028.1" /db_xref="EnsemblGenomes-Gn:BSU31500" /db_xref="EnsemblGenomes-Tr:CAB15139" /db_xref="InterPro:IPR007263" /db_xref="SubtiList:BG10978" /db_xref="UniProtKB/Swiss-Prot:P40761" /translation="MTSEQIPNRVLLFDGVCNLCNGAVQFIIKRDPDGLISFTSLQSE TGQSLLKKSGLPTDRFDSFVFIEDGQVYTKSTAAIKVFRHLRGPWRLFVLFFAVPKPV RDMVYSFIAKNRYKWFGKKNECMLPSPSIKKRFLP*" /label="yuxK CDS" gene 2754051..2754464 /gene="yuxK" /locus_tag="BSU_31500" /old_locus_tag="BSU31500" /label="yuxK gene" downshifts 2754456 /Source="Nicolas_upshifts" /id="D1633" /incds=0 /nref=1 /ntot=254 /MaxReadThrough="5.05064" /MaxDrop="3.14634" /score="-3.58105315" /energy="-11.5" /TU="U2456" /idTUdmin="U2456" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2754667..2755224) /gene="yufK" /locus_tag="BSU_31510" /old_locus_tag="BSU31510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391029.2" /db_xref="EnsemblGenomes-Gn:BSU31510" /db_xref="EnsemblGenomes-Tr:CAB15140" /db_xref="GOA:O05249" /db_xref="InterPro:IPR035289" /db_xref="SubtiList:BG12346" /db_xref="UniProtKB/Swiss-Prot:O05249" /translation="MKNTYLTGYFPLIAILLFSSSLSISTSLYALKMLSSFGMYDGML DYFSEKGIRLALFAAFALLYFMVLSALKLIANTVTELSLLFFANDPEGNNLKKLRMGS MIYLGGGILSFVLLQNVIWIVIWFAVVTLAYFVFTVYRIYSTLSLMSLVGFILLELLF WFTFVIGILFIFIKLYNSIMASLPV*" /label="yufK CDS" gene complement(2754667..2755224) /gene="yufK" /locus_tag="BSU_31510" /old_locus_tag="BSU31510" /label="yufK gene" misc_feature 2754688..2754707 /Source="Nicolas_upshift_promotors" /id="U2458" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.845154845154845" /psig="0.878121878121878" /xcortree=2785 /SigmaFactorBS="tctgaccaccaaacgctgaaatggctagcttacacaggtaag ctagccatTATGCTATTATAAAGCTTGAtaaatatgaacagaataccgataacaaagg t" /listShort="S1207" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2754698 /Source="Nicolas_upshifts" /id="U2458" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.845154845154845" /psig="0.878121878121878" /xcortree=2785 /SigmaFactorBS="tctgaccaccaaacgctgaaatggctagcttacacaggtaag ctagccatTATGCTATTATAAAGCTTGAtaaatatgaacagaataccgataacaaagg t" /listShort="S1207" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2754708) /Source="Nicolas_upshifts" /id="D1634" /incds=0 /nref=10 /ntot=201 /MaxReadThrough="3.90201" /MaxDrop="3.94501" /score="-6.00543052" /energy="-18.5" /TU="U2459" /idTUdmin="U2459" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" S_feature 2754720..2755401 /Source="Nicolas_S_feature" /locus_tag="new_3236475_3237156" /HighExp="Diami, Cold, LBGstat, H2O2, Lbtran, Gly, M0t90, GM 10, GM-0.2, dia15" /AntisenseName="yufK" /AntisenseCor="0.32488342936044701" /AntisenseRegPval="-7.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.878" /TUlongSig="NA" /TUlongPSig="NA" /label="S1207" promotor_-10 complement(2755250..2755269) /Source="Nicolas_upshift_promotors" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2755258) /Source="Nicolas_upshifts" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2755285..2755289) /Source="Nicolas_upshift_promotors" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2755402..2757003 /gene="maeL" /locus_tag="BSU_31520" /old_locus_tag="BSU31520" /EC_number="2.7.13.3" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12949159, 12949160, 22001508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12949159, 12949160, 22001508; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [MaeM]" /protein_id="NP_391030.1" /db_xref="EnsemblGenomes-Gn:BSU31520" /db_xref="EnsemblGenomes-Tr:CAB15141" /db_xref="GOA:O05250" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12347" /db_xref="UniProtKB/Swiss-Prot:O05250" /translation="MKKTLKLQTRLTIFVCIVVLIALLITFFTVGAQTTKRIRDQEKA TALQTAEMVAEAPMTAAALESGKKQKELQSYTKRVQKITGTEFVVVMDMNGIRKTHPD PSKIGKKFRGGDESEVLKGHVHISTASGTLGKSQRAFVPVYAENGKQVGAVAVGITVN EIDEVISHSLRPLYFIICVSIFVGVIGAVIVARTVKNIMYGLEPYEIATLLEERSAML ESTKEGILAVDEHGKIKLANAEAKRLFVKMGINTNPIDQDVDDILPKSRLKKVIETKK PLQDRDVRINGLELVFNEVPIQLKGQTVGAIATFRDKTEVKHLAEQLSGVKMYANALR AQSHEFMNKLHVILGLVQLKEYDDLGDYIKDIAIQQKSETSEIINDVKSSVLAGFLLG KQSFIREQGANLDIECNGVIPNAADPSVIHELITIIGNLINNGLDAVADMPKKQITMS MRFHNSILDIEITDTGAGMSEEDQAKVFEQGYSTKGKNRGFGLYFTQQSIENLKGQMI LTSEKNEGTTFSIRIPYEPKEENHD*" /label="maeL CDS" gene 2755402..2757003 /gene="maeL" /locus_tag="BSU_31520" /old_locus_tag="BSU31520" /label="maeL gene" CDS 2756996..2757703 /gene="maeM" /locus_tag="BSU_31530" /old_locus_tag="BSU31530" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12949159, 12949160, 22001508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12949159, 12949160, 22001508; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator for malate metabolism [MaeL]" /protein_id="NP_391031.1" /db_xref="EnsemblGenomes-Gn:BSU31530" /db_xref="EnsemblGenomes-Tr:CAB15142" /db_xref="GOA:O05251" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12348" /db_xref="UniProtKB/Swiss-Prot:O05251" /translation="MINVLIVEDDPMVGELNKRYLSQIDGFQLKGIASSFQSALHILG EHHIDLILLDIYMPGKNGLELLTELRAQNEAVDVIVISAASELDVIKKTLRYGAVDYL IKPFEFERFQTALSDYRRKQKVYSTHRNMSQKELDAELFQKKEATEKVQLPKGLTKST LKLIWSSIQSFENESFTTEDLAKHTEISQVSIRKYLKFLEDIQVLNVEMAYGTIGRPV FQYNVNNSNINGIKQYL*" /label="maeM CDS" gene 2756996..2757703 /gene="maeM" /locus_tag="BSU_31530" /old_locus_tag="BSU31530" /label="maeM gene" downshifts 2757688 /Source="Nicolas_upshifts" /id="D1635" /incds=0 /nref=173 /ntot=245 /MaxReadThrough="1.97489" /MaxDrop="5.86018" /score="19.9464971" /energy="-15.3" /TU="NA" /idTUdmin="U2458" /TUdmin=2660 /isTUend="FALSE" /label="downshifts" promotor_-35 2757867..2757874 /Source="Nicolas_upshift_promotors" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2757885..2758174 /Source="Nicolas_S_feature" /locus_tag="new_3239640_3239929" /HighExp="T1.30H, T1.0H, T2.30H, T2.0H, M9-stat, S1, T3.0H, T3.30H, T0.30H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1208" upshifts 2757885 /Source="Nicolas_upshifts" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2757889..2757908 /Source="Nicolas_upshift_promotors" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2758175..2759254 /gene="nupN" /locus_tag="BSU_31540" /old_locus_tag="BSU31540" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:21926227, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21926227, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein involved in guanosine transport" /protein_id="NP_391032.2" /db_xref="EnsemblGenomes-Gn:BSU31540" /db_xref="EnsemblGenomes-Tr:CAB15143" /db_xref="GOA:O05252" /db_xref="InterPro:IPR003760" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12349" /db_xref="UniProtKB/Swiss-Prot:O05252" /translation="MNKRKIGLAMSLVIAAGTILGACGNSEKSSGSGEGKNKFSVAMV TDVGGVDDKSFNQSAWEGIQAFGKENGLKKGKNGYDYLQSKSDADYTTNLNKLARENF DLIYGVGYLMEDSISEIADQRKNTNFAIIDAVVDKDNVASITFKEQEGSFLVGVAAAL SSKSGKIGFVGGMESELIKKFEVGFRAGVQAVNPKAVVEVKYAGGFDKADVGKATAES MYKSGVDVIYHSAGATGTGVFTEAKNLKKEDPKRDVWVIGVDKDQYAEGQVEGTDDNV TLTSMVKKVDTVVEDVTKKASDGKFPGGETLTYGLDQDGVGISPSKQNLSDDVIKAVD KWKKKIIDGLEIPATEKELKTFKAE*" /label="nupN CDS" gene 2758175..2759254 /gene="nupN" /locus_tag="BSU_31540" /old_locus_tag="BSU31540" /label="nupN gene" CDS 2759330..2760862 /gene="nupO" /locus_tag="BSU_31550" /old_locus_tag="BSU31550" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:21926227, 25875741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21926227, 25875741; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanosine ABC transporter (ATP-binding protein)" /protein_id="NP_391033.1" /db_xref="EnsemblGenomes-Gn:BSU31550" /db_xref="EnsemblGenomes-Tr:CAB15144" /db_xref="GOA:O05253" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12350" /db_xref="UniProtKB/Swiss-Prot:O05253" /translation="MEYVIEMLNIRKAFPGIVANDNINLQVKKGEIHALLGENGAGKS TLMNVLFGLYQPERGEIRVRGEKVHINSPNKANDLGIGMVHQHFMLVDTFTVAENIIL GKEPKKFGRIDRKRAGQEVQDISDRYGLQIHPEAKAADISVGMQQRAEILKTLYRGAD ILIFDEPTAVLTPHEIKELMQIMKNLVKEGKSIILITHKLKEIMEICDRVTVIRKGKG IKTLDVRDTNQDELASLMVGREVSFKTEKRAAQPGAEVLAIDGITVKDTRGIETVRDL SLSVKAGEIVGIAGVDGNGQSELIEAVTGLRKTDSGTITLNGKQIQNLTPRKITESGI GHIPQDRHKHGLVLDFPIGENILLQSYYKKPYSALGVLHKGEMYKKARSLITEYDVRT PDEYTHARALSGGNQQKAIIGREIDRNPDLLIAAQPTRGLDVGAIEFVHKKLIEQRDA GKAVLLLSFELEEIMNLSDRIAVIFEGRIIASVNPQETTEQELGLLMAGSTQKEAGKA NG*" /label="nupO CDS" gene 2759330..2760862 /gene="nupO" /locus_tag="BSU_31550" /old_locus_tag="BSU31550" /label="nupO gene" CDS 2760855..2761901 /gene="nupP" /locus_tag="BSU_31560" /old_locus_tag="BSU31560" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21926227" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21926227; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease of ABC guanosine transporter" /protein_id="NP_391034.1" /db_xref="EnsemblGenomes-Gn:BSU31560" /db_xref="EnsemblGenomes-Tr:CAB15145" /db_xref="GOA:O05254" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR002229" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12351" /db_xref="UniProtKB/Swiss-Prot:O05254" /translation="MVKRLSHLLVPLIAIILGLAAGALIMLVSGYSVASGYSALWNGI FGEIYYVGETIRQITPYILSGLAVAFAFRTGLFNIGVEGQLLVGWTAAVWVGTAFDGP AYIHLPLALITAAAAGGLWGFIPGILKARFYVHEVIVTIMMNYIALHMTNYIISNVLT DHQDKTGKIHESASLRSPFLEQITDYSRLHLGIIVALLAAVIMWFIINKSTKGFELRA VGFNQHASQYAGMSVRKNIMTSMLISGAFAGLAGAMEGLGTFEYAAVKGAFTGVGFDG IAVALLGGNTAVGVVLAACLLGGLKIGALNMPIESGVPSEVVDIVIAIIILFVASSYA IRFVMGKLKKKGAN*" /label="nupP CDS" gene 2760855..2761901 /gene="nupP" /locus_tag="BSU_31560" /old_locus_tag="BSU31560" /label="nupP gene" CDS 2761902..2762861 /gene="nupQ" /locus_tag="BSU_31570" /old_locus_tag="BSU31570" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21926227" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21926227; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease of ABC guanosine transporter" /protein_id="NP_391035.1" /db_xref="EnsemblGenomes-Gn:BSU31570" /db_xref="EnsemblGenomes-Tr:CAB15146" /db_xref="GOA:O05255" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12352" /db_xref="UniProtKB/Swiss-Prot:O05255" /translation="MDIVQILSIIVPATLVYAAPLILTALGGVFSERSGVVNIGLEGL MIIGAFTSVLFNLFFGQELGAAAPWLSLLAAMAAGALFSLIHAAAAISFRADQTVSGV AINMLALGATLFIVKLIYGKAQTDKIPEPFYKTKIPGLGDIPVLGKIFFSDVYYTSIL AIALAFISWFILFKTPFGLRIRSVGEHPMAADTMGINVYKMRYIGVMISGLFGGLGGG VYASTIALDFTHSTISGQGFIALAALVFGKWHPIGALGAALFFGFAQSLSIIGSLLPL FKDIPNVYMLMAPYILTILALTGFIGRADAPKANGVPYIKGKR*" /label="nupQ CDS" gene 2761902..2762861 /gene="nupQ" /locus_tag="BSU_31570" /old_locus_tag="BSU31570" /label="nupQ gene" S_feature 2762862..2762983 /Source="Nicolas_S_feature" /locus_tag="new_3244617_3244738" /HighExp="S1, BT, M9-stat, T1.30H, S2, LoTm, T1.0H, T2.30H, T2.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1209" promotor_-35 2762956..2762959 /Source="Nicolas_upshift_promotors" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2762974..2762993 /Source="Nicolas_upshift_promotors" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2762985 /Source="Nicolas_upshifts" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="upshifts" CDS 2763015..2764361 /gene="maeN" /locus_tag="BSU_31580" /old_locus_tag="BSU31580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 12949159, 15849754, 16850406, 17183219, 19087206, 19114526, 20011599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 12949159, 15849754, 16850406, 17183219, 19087206, 19114526, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/malate symporter" /protein_id="NP_391036.1" /db_xref="EnsemblGenomes-Gn:BSU31580" /db_xref="EnsemblGenomes-Tr:CAB15147" /db_xref="GOA:O05256" /db_xref="InterPro:IPR004679" /db_xref="InterPro:IPR018025" /db_xref="SubtiList:BG12353" /db_xref="UniProtKB/Swiss-Prot:O05256" /translation="MGAIPKTGTISPEQKDSQEKNLFQKIWSWEIGVIPLPLYTVLAV IIILAAYYNELPANMLGGFAIIMILGVFLGDIGQRIPILKDIGGPAILSLFVPSFLVF YNVLNSTSLDAVTNLMKTSNFLYFYIACLVVGSILGMNRIVLIQGFIRMFVPLVAGTI AAVAAGILVGFIFGYSAYDSFFFVVVPIIAGGIGEGILPLSIAYSQILGSSADVFVSQ LVPAAIIGNVFAIICAALMKKLGDKRPDLNGNGRLVKSKKANEIFNQKEAEAKIDFKL MGAGVLLACTFFIFGGLLEKFIFIPGAILMIISAAAVKYANILPKKMEEGAYQLYKFI SSSFTWPLMVGLGILFIPLDDVASVISIPFVIICISVVIAMIGSGYFVGKLMNMYPVE SAIVTCCHSGLGGTGDVAILSASGRMGLMPFAQISTRLGGAGTVICATVLLRFFTS*" /label="maeN CDS" gene 2763015..2764361 /gene="maeN" /locus_tag="BSU_31580" /old_locus_tag="BSU31580" /label="maeN gene" downshifts 2764344 /Source="Nicolas_upshifts" /id="D1636" /incds=0 /nref=68 /ntot=109 /MaxReadThrough="0.286069999999999" /MaxDrop="6.51197" /score="36.240717" /energy="-12.2" /TU="NA" /idTUdmin="U2461" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" CDS complement(2764397..2764612) /gene="yufS" /locus_tag="BSU_31590" /old_locus_tag="BSU31590" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative bacteriocin" /protein_id="NP_391037.1" /db_xref="EnsemblGenomes-Gn:BSU31590" /db_xref="EnsemblGenomes-Tr:CAB15148" /db_xref="GOA:O05257" /db_xref="SubtiList:BG12354" /db_xref="UniProtKB/Swiss-Prot:O05257" /translation="MKTKVVMCSGLFCSVFAGAFMLNQYDGRSGVAACDEWELYLLEH HLSARMSETESKDLPFGPREYIRIVNK*" /label="yufS CDS" gene complement(2764397..2764612) /gene="yufS" /locus_tag="BSU_31590" /old_locus_tag="BSU31590" /label="yufS gene" promotor_-35 2764552..2764558 /Source="Nicolas_upshift_promotors" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2764572..2764583 /Source="Nicolas_upshift_promotors" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2764576 /Source="Nicolas_upshifts" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2764623..2764641) /Source="Nicolas_upshift_promotors" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2764630) /Source="Nicolas_upshifts" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2764655..2764662 /Source="Nicolas_upshift_promotors" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2764657..2764662) /Source="Nicolas_upshift_promotors" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2764677..2764772 /Source="Nicolas_S_feature" /locus_tag="new_3246432_3246527" /HighExp="G180, Diami, G150, Oxctl, G135, H2O2, Paraq, MG 60, MG 15, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1210" promotor_-10 2764677..2764696 /Source="Nicolas_upshift_promotors" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2764677 /Source="Nicolas_upshifts" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2764735..2764739 /Source="Nicolas_upshift_promotors" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2764755..2764774 /Source="Nicolas_upshift_promotors" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2764774..2764923 /Source="Nicolas_S_feature" /locus_tag="new_3246529_3246678" /HighExp="G135, G180, Diami, G150, H2O2, Oxctl, LBGexp, Paraq, Salt, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1211" upshifts 2764774 /Source="Nicolas_upshifts" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="upshifts" CDS 2764843..2767248 /gene="mrpA" /locus_tag="BSU_31600" /old_locus_tag="BSU31600" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 21236240, 24095649, 24139955, 27391676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 21236240, 24095649, 24139955, 27391676; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sodium transporter component of a Na+/H+ antiporter" /protein_id="NP_391038.2" /db_xref="EnsemblGenomes-Gn:BSU31600" /db_xref="EnsemblGenomes-Tr:CAB15149" /db_xref="GOA:Q9K2S2" /db_xref="InterPro:IPR001516" /db_xref="InterPro:IPR001750" /db_xref="InterPro:IPR005663" /db_xref="InterPro:IPR018393" /db_xref="InterPro:IPR025383" /db_xref="SubtiList:BG12355" /db_xref="UniProtKB/Swiss-Prot:Q9K2S2" /translation="MQLLHLAILSPFLFAFIIPFLAKYAKRVHTGWFVLILPVLLFIY FLPMIRMTQSGETLRSVLEWIPSLGINFTVYIDGLGLLFALLITGIGSLVTLYSIFYL SKEKEQLGPFYVYLLMFMGAMLGVVLVDNVMVLYMFWELTSLSSFLLIGYWYKREKSR YGAAKSLLITVSGGLCMLGGFILLYLITDSFSIREMVHQVQLIAGHELFIPAMILILL GAFTKSAQFPFYIWLPDAMEAPTPVSAYLHSATMVKAGIYVIARFSPIFAFSAQWFWI VSLVGLFTMVWGSFHAVKQTDLKSILAFSTVSQLGMIISMLGVSAAALHYGHTEYYTV AAMAAIFHLINHATFKGSLFMAVGIIDHETGTRDIRKLGGLMAIMPITFTISLIGTFS MAGLPPFNGFLSKEMFFTSMLRVTHFDLFNVQTWGVLFPLFAWIGSVFTFIYSMKLLF KTFRGNYQPEQLEKQAHEAPVGMLVPPVILVALAVSLFFFPNILSYSLIEPAMNSIYP TLLDGHEKFHVHISQWHGVTTELLMTAGIVVIGTIGYLSLNKWKGIYKLFPSKLTLNR LYDKLLTMMEKGSYRVTKQYMTGFLRDYLLYIFAGFIILIGGAFAIKGGFSFKTEGMA KIGVYEIILTLVMISATVATVFARSRLTAIIALGVVGYTLALFFVIFRAPDLALTQLV IETISVALFLLCFYHLPKLRLKTKTRTFRMTNFIISLGVGVIVTLLGIASSSQRTKDS IASFFVKHSHDLGGGDNVVNVILVDFRGFDTMFEITVLTIAALGIYSMIKTKVKEEGK SGE*" /label="mrpA CDS" gene 2764843..2767248 /gene="mrpA" /locus_tag="BSU_31600" /old_locus_tag="BSU31600" /label="mrpA gene" CDS 2767241..2767672 /gene="mrpB" /locus_tag="BSU_31610" /old_locus_tag="BSU31610" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 19389778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 19389778; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter complex" /protein_id="NP_391039.1" /db_xref="EnsemblGenomes-Gn:BSU31610" /db_xref="EnsemblGenomes-Tr:CAB15150" /db_xref="GOA:O05259" /db_xref="InterPro:IPR005281" /db_xref="InterPro:IPR007182" /db_xref="SubtiList:BG12356" /db_xref="UniProtKB/Swiss-Prot:O05259" /translation="MNEQKTNDLILQTATKLVSFIILLFSFYLFLSGHNAPGGGFVGG LITSSSIVLLLLAYDLKTVRSLLPVNFIYVAGAGLLLAVLTGVGSFVFGAPFLTHTFG YFQLPILGKTELATATIFDLGVYLVVVGITMTIIQTIGEEE*" /label="mrpB CDS" gene 2767241..2767672 /gene="mrpB" /locus_tag="BSU_31610" /old_locus_tag="BSU31610" /label="mrpB gene" CDS 2767672..2768013 /gene="mrpC" /locus_tag="BSU_31620" /old_locus_tag="BSU31620" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 24021651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 24021651; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of Na+/H+ antiporter" /protein_id="NP_391040.2" /db_xref="EnsemblGenomes-Gn:BSU31620" /db_xref="EnsemblGenomes-Tr:CAB15151" /db_xref="GOA:O05260" /db_xref="SubtiList:BG12357" /db_xref="UniProtKB/Swiss-Prot:O05260" /translation="MEILMAVLAGIIFMAATYLLLSKSLLRVIIGTALLSHGVHLMLL TMGGLKKGAAPILSEHAKSFVDPLPQALILTAIVISFGVTSFILVMAFRAYQELKSDD MDQMRGNDQHE*" /label="mrpC CDS" gene 2767672..2768013 /gene="mrpC" /locus_tag="BSU_31620" /old_locus_tag="BSU31620" /label="mrpC gene" promotor_no_box 2767904..2768004 /Source="Nicolas_upshift_promotors" /id="U2466" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.387612387612388" /psig="0.387612387612388" /xcortree=1779 /SigmaFactorBS="tcatttcttttggcgttacgtcattcatcctcgtcatggcct ttcgcgcttatcaggaattgaaatcggacgatatggatcaaatgaggggaaatgatca a" /listShort="mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2767964 /Source="Nicolas_upshifts" /id="U2466" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.387612387612388" /psig="0.387612387612388" /xcortree=1779 /SigmaFactorBS="tcatttcttttggcgttacgtcattcatcctcgtcatggcct ttcgcgcttatcaggaattgaaatcggacgatatggatcaaatgaggggaaatgatca a" /listShort="mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="upshifts" CDS 2768006..2769487 /gene="mrpD" /locus_tag="BSU_31630" /old_locus_tag="BSU31630" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 21236240, 24095649, 27391676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 21236240, 24095649, 27391676; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton transporter component of Na+/H+ antiporter" /protein_id="NP_391041.3" /db_xref="EnsemblGenomes-Gn:BSU31630" /db_xref="EnsemblGenomes-Tr:CAB15152" /db_xref="GOA:O05229" /db_xref="InterPro:IPR001750" /db_xref="InterPro:IPR003918" /db_xref="InterPro:IPR004775" /db_xref="SubtiList:BG12345" /db_xref="UniProtKB/Swiss-Prot:O05229" /translation="MNNFVILPILIPLLSAILLIFMTKNLMLMRIFSTAASAIGIVIS GILVQTVFTKGIQTLSLGGWKAPYGIVLAADQFASLLVLTTAIIGLLVGLYSFRSVGE KRERSFYYSGVQFLLAGVSGAFLTGDLFNMYVFFELLLIASYMLIVLGGTKIQLRESL KYIVFNIVSSALFVIGVGFLYAVTGTLNMADLSVKISESGQTGLITVIGVLLLLVFGM KGGIFPLYFWLPGSYYAPPAAISALFGALLTKVGLYAITRVFTLIFIHDTAFTHQLMI WLAALTVIFGVIGSLAYSNVMKIVIYNIITAVGVILFGVAVHTPASIQGAIYYLIHDM LIKGALFMLAGTLIALTGTASLHKMGGLIKRYPVLGWMFFISAISLAGIPPLSGFVGK FKIAEGGFAEGEFTISMLILLSSLLVLYSVLRIFIHAFWGEEKETPKPNHRTAKGLLY PAAIFLLLSLLFGLGTEWVSPYVDQAAETLLNPEKYIEAVLKE*" /label="mrpD CDS" gene 2768006..2769487 /gene="mrpD" /locus_tag="BSU_31630" /old_locus_tag="BSU31630" /label="mrpD gene" S_feature complement(2768739..2770607) /Source="Nicolas_S_feature" /locus_tag="new_3250494_3252362_c" /HighExp="S2, Lbstat, T5.0H, T3.30H, S3, T4.0H, T3.0H, T2.30H, S1, T2.0H" /AntisenseName="mrpD" /AntisenseCor="-0.59706140653928796" /AntisenseRegPval="-26.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1212" CDS 2769493..2769969 /gene="mrpE" /locus_tag="BSU_31640" /old_locus_tag="BSU31640" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10198001, 11004162, 15849754, 16233411, 16850406, 24142251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10198001, 11004162, 15849754, 16233411, 16850406, 24142251; Product type t : transporter" /codon_start=1 /transl_table=11 /product="non essential component of Na+/H+ antiporter" /protein_id="YP_054591.2" /db_xref="EnsemblGenomes-Gn:BSU31640" /db_xref="EnsemblGenomes-Tr:CAE01465" /db_xref="GOA:Q7WY60" /db_xref="InterPro:IPR002758" /db_xref="SubtiList:BG14181" /db_xref="UniProtKB/Swiss-Prot:Q7WY60" /translation="MAFQILLNVFLAFCWMFLSNSPSAAGFITGYILGMLSLFFFRRF FTRQFYLWKLISIIKLCFIFIKELYLANVSVMKSVLSPKLNIRPGIFAFKTELTKDWE ITMLSLLITLTPGTLVMDISDDRTILYIHAMDIEDAEKAIFDIRESFEKAIQEVSR*" /label="mrpE CDS" gene 2769493..2769969 /gene="mrpE" /locus_tag="BSU_31640" /old_locus_tag="BSU31640" /label="mrpE gene" CDS 2769969..2770253 /gene="mrpF" /locus_tag="BSU_31650" /old_locus_tag="BSU31650" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10198001, 11004162, 11356194, 12682299, 15019740, 24142251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10198001, 11004162, 11356194, 12682299, 15019740, 24142251; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux transporter for Na+ and cholate" /protein_id="NP_391043.2" /db_xref="EnsemblGenomes-Gn:BSU31650" /db_xref="EnsemblGenomes-Tr:CAB15153" /db_xref="GOA:O05228" /db_xref="InterPro:IPR007208" /db_xref="SubtiList:BG12344" /db_xref="UniProtKB/Swiss-Prot:O05228" /translation="MFTLILQIALGIMAVSTFLYVIRVIKGPTVPDRVVALDAIGINL IAITALVSILLKTSAFLDIILLLGILSFIGTIAFSKFLEKGEIIENDRNR*" /label="mrpF CDS" gene 2769969..2770253 /gene="mrpF" /locus_tag="BSU_31650" /old_locus_tag="BSU31650" /label="mrpF gene" CDS 2770237..2770611 /gene="mrpG" /locus_tag="BSU_31660" /old_locus_tag="BSU31660" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 15019740, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 15019740, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="non essential component of Na+/H+ antiporter" /protein_id="NP_391044.1" /db_xref="EnsemblGenomes-Gn:BSU31660" /db_xref="EnsemblGenomes-Tr:CAB15154" /db_xref="GOA:O05227" /db_xref="InterPro:IPR005133" /db_xref="SubtiList:BG12343" /db_xref="UniProtKB/Swiss-Prot:O05227" /translation="MIETAKVVVAVFILLGALICLIASFGVLRLPDVFTRAHAASKGS TLGVNMILLGVFFYLWFVTGELSAKILLGILFIFITSPIGGHLICRAAYNSGVKLDER SVQDDYNGIRNFVIKRKEDSYL*" /label="mrpG CDS" gene 2770237..2770611 /gene="mrpG" /locus_tag="BSU_31660" /old_locus_tag="BSU31660" /label="mrpG gene" downshifts 2770582 /Source="Nicolas_upshifts" /id="D1637" /incds=0 /nref=86 /ntot=185 /MaxReadThrough="1.46493" /MaxDrop="6.023" /score="32.1865197" /energy="-12.7" /TU="NA" /idTUdmin="U2464" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2770650..2771030) /gene="yuxO" /locus_tag="BSU_31670" /old_locus_tag="BSU31670" /EC_number="3.1.-.-" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25010423; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative proofreading thioesterase in bacillibactin biosynthesis" /protein_id="NP_391045.2" /db_xref="EnsemblGenomes-Gn:BSU31670" /db_xref="EnsemblGenomes-Tr:CAB15155" /db_xref="GOA:P14205" /db_xref="InterPro:IPR003736" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG10382" /db_xref="UniProtKB/Swiss-Prot:P14205" /translation="MDMKHTLLEALGIEIVENTAERCVAVMPVDHRTVQPFGYLHGGA SVALAETAASAGAQNLIDHTTQACVGLEINANHLKSVKEGTVKAIAEPVHIGRTTIVY HIHIYDEQERLICISRCTLAVIKK*" /label="yuxO CDS" gene complement(2770650..2771030) /gene="yuxO" /locus_tag="BSU_31670" /old_locus_tag="BSU31670" /label="yuxO gene" downshifts complement(2770652) /Source="Nicolas_upshifts" /id="D1638" /incds=0 /nref=41 /ntot=206 /MaxReadThrough="4.53972" /MaxDrop="3.98532" /score="-4.4938943" /energy="-12.7" /TU="U2469" /idTUdmin="U2469" /TUdmin="-1050" /isTUend="FALSE" /label="downshifts" CDS complement(2771049..2771693) /gene="comA" /locus_tag="BSU_31680" /old_locus_tag="BSU31680" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972833, 11179649, 11717295, 12950917, 16816200, 17827323, 26582911" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972833, 11179649, 11717295, 12950917, 16816200, 17827323, 26582911; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response quorum-sensing regulator" /protein_id="NP_391046.1" /db_xref="EnsemblGenomes-Gn:BSU31680" /db_xref="EnsemblGenomes-Tr:CAB15156" /db_xref="GOA:P14204" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:2KRF" /db_xref="PDB:3ULQ" /db_xref="SubtiList:BG10381" /db_xref="UniProtKB/Swiss-Prot:P14204" /translation="MKKILVIDDHPAVMEGTKTILETDSNLSVDCLSPEPSEQFIKQH DFSSYDLILMDLNLGGEVNGMELSKQILQENPHCKIIVYTGYEVEDYFEEAIRAGLHG AISKTESKEKITQYIYHVLNGEILVDFAYFKQLMTQQKTKPAPSSQKEQDVLTPRECL ILQEVEKGFTNQEIADALHLSKRSIEYSLTSIFNKLNVGSRTEAVLIAKSDGVL*" /label="comA CDS" gene complement(2771049..2771693) /gene="comA" /locus_tag="BSU_31680" /old_locus_tag="BSU31680" /label="comA gene" S_feature complement(2771694..2771773) /Source="Nicolas_S_feature" /locus_tag="new_3253449_3253528_c" /HighExp="S2, Lbstat, M0t90, M40t90, MG 5, S1, ferm, T1.30H, nit, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1213" CDS complement(2771774..2774083) /gene="comP" /locus_tag="BSU_31690" /old_locus_tag="BSU31690" /EC_number="2.7.-.-" /function="16.12: Sense" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 7698645, 7855425, 10419951, 14679219, 15066026, 16091050, 16787201, 20208433, 24130811; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_391047.2" /db_xref="EnsemblGenomes-Gn:BSU31690" /db_xref="EnsemblGenomes-Tr:CAB15157" /db_xref="GOA:Q99027" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10380" /db_xref="UniProtKB/Swiss-Prot:Q99027" /translation="MKNLIKKFTIAVIVLSILYISYTTYISMNGIIIGTKIHKNDKSQ FMIEEISESSYGQFVGLRQGDIILKINKEKPSDKHLKWGYLSHINSLDILRSGKKIHL KDFDLVTLNRPYSFFLFVLPLFFYFLSIICIFYILKVNKKRRSFAAYILILLLLDISI AYISAGGPFRGHIINRYINLFTFISSPILYLQFIQRYLGEIGKTFLNRISFLYIIPIF NLGIEFFQDYLQVDIDFLATLNLVSFATLTLFSFSAIYLHLNKYKYAEHSFILKLLIL TNTLSFAPFLIFFVLPIIFTGNYIFPALASASLLVLIPFGLVYQFVANKMFDIEFILG RMRYYALLAMIPTLLIVGALVLFDVMDIQMNPVRQTVFFFVVMFAVFYFKEVMDFKFR LKRFSEKFNYQDSIFKYTQLMRGVTSLQQVFKELKNTILDVLLVSKAYTFEVTPDHKV IFLDKHEVGPDWNFYQEEFENVTSEIGKIIEVNQGFLMKVGERGGSSYVLLCLSNINT PRLTRDEISWLKTLSFYTSVSMENVLHIEELMEHLKDLKQEGTNPIWLKKLMFAIEEK QRSGLARDLHDSVLQDLISLKRQCELFLGDFKKDDNPCREEVQDKLVQMNEQMSDVIS MTRETCHELRPQLLYDLGLVKALSKLVAQQQERVPFHIRLNTGRFTASLDLDSQLNLY RIIQEFLSNAVKHSQATDVLIMLISIQNKIVLHYEDDGVGFDQEKNTEHSMSMGLSGI KERVRALDGRLRIETSEGKGFKADIEIEL*" /label="comP CDS" gene complement(2771774..2774083) /gene="comP" /locus_tag="BSU_31690" /old_locus_tag="BSU31690" /label="comP gene" promotor_-35 2772768..2772775 /Source="Nicolas_upshift_promotors" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2772789..2772808 /Source="Nicolas_upshift_promotors" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2772804 /Source="Nicolas_upshifts" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 2773677..2774648 /Source="Nicolas_S_feature" /locus_tag="new_3255432_3256404" /HighExp="S8, C30, S7, Gly, Lbstat, Fru, C90, Pyr, G135, M/G" /AntisenseName="comX" /AntisenseCor="-2.6572990440080099E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.606" /TUlongSig="NA" /TUlongPSig="NA" /label="S1214" upshifts 2773677 /Source="Nicolas_upshifts" /id="U2468" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.281718281718282" /psig="0.606393606393606" /xcortree=660 /SigmaFactorBS="aataacaatagaataagaatataggcagcaaatgatctcctt tttttatttactttaagtatataaaaaataCATATTATGCTTAAAAAataaaaaaaca a" /listShort="S1214" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2773689..2773705 /Source="Nicolas_upshift_promotors" /id="U2468" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.281718281718282" /psig="0.606393606393606" /xcortree=660 /SigmaFactorBS="aataacaatagaataagaatataggcagcaaatgatctcctt tttttatttactttaagtatataaaaaataCATATTATGCTTAAAAAataaaaaaaca a" /listShort="S1214" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2774098..2774265) /gene="comX" /locus_tag="BSU_31700" /old_locus_tag="BSU31700" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11751817, 12067344, 14679219, 16407988, 17240141, 18323630, 21636272, 21821957, 28326143, 28391484" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751817, 12067344, 14679219, 16407988, 17240141, 18323630, 21636272, 21821957, 28326143, 28391484; Product type f: factor" /codon_start=1 /transl_table=11 /product="competence pheromone precursor (pheromone peptide aa 46->55, geranyl-modified)" /protein_id="NP_391048.1" /db_xref="EnsemblGenomes-Gn:BSU31700" /db_xref="EnsemblGenomes-Tr:CAB15158" /db_xref="GOA:P45453" /db_xref="InterPro:IPR009233" /db_xref="SubtiList:BG11324" /db_xref="UniProtKB/Swiss-Prot:P45453" /translation="MQDLINYFLNYPEALKKLKNKEACLIGFDVQETETIIKAYNDYY LADPITRQWGD*" /label="comX CDS" gene complement(2774098..2774265) /gene="comX" /locus_tag="BSU_31700" /old_locus_tag="BSU31700" /label="comX gene" CDS complement(2774253..2775151) /gene="comQ" /locus_tag="BSU_31710" /old_locus_tag="BSU31710" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751817, 12067344, 14679219, 16407988, 16452308, 17240141, 22878193, 24425772, 25036949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751817, 12067344, 14679219, 16407988, 16452308, 17240141, 22878193, 24425772, 25036949; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoprenyl transferase (pre-ComX modification)" /protein_id="NP_391049.2" /db_xref="EnsemblGenomes-Gn:BSU31710" /db_xref="EnsemblGenomes-Tr:CAB15159" /db_xref="GOA:P33690" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR033965" /db_xref="SubtiList:BG10379" /db_xref="UniProtKB/Swiss-Prot:P33690" /translation="MKEIVEQNIFNEDLSQLLYSFIDSKETFSFAESTILHYVVFGGE NLDVATRLGAGIEILILSSDIMDDLEDEDNHHALWMKINRSESLNAALSLYTVGLTSI YSLNNNPLIFKYVLKYVNEAMQGQHDDITNKSKTEDESLEVIRLKCGSLIALANVAGV LLATGEYNETVERYSYYKGIIAQISGDYYVLLSGNRSDIEKNKHTLIYLYLKRLFNDA SEDLLYLISHKDLYYKSLLDKEKFQEKLIKAGVTQYISVLLEIYKQKCISAIEQLNLD KEKKS**RNAY*VIQRGIQDARP" /label="comQ CDS" gene complement(2774253..2775151) /gene="comQ" /locus_tag="BSU_31710" /old_locus_tag="BSU31710" /label="comQ gene" S_feature complement(2775152..2775265) /Source="Nicolas_S_feature" /locus_tag="new_3256908_3257021_c" /HighExp="M9-stat, T1.30H, T0.30H, T1.0H, S4, T2.30H, M0t90, S5, M40t90, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1215" promotor_-10 complement(2775259..2775278) /Source="Nicolas_upshift_promotors" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2775265) /Source="Nicolas_upshifts" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2775292..2775298) /Source="Nicolas_upshift_promotors" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2775336..2775476) /gene="degQ" /locus_tag="BSU_31720" /old_locus_tag="BSU31720" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1901055, 16251307, 16942812, 17827323, 21965392, 26302846, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901055, 16251307, 16942812, 17827323, 21965392, 26302846, 27920766; Product type r: regulator" /codon_start=1 /transl_table=11 /product="pleiotropic regulator" /protein_id="NP_391050.1" /db_xref="EnsemblGenomes-Gn:BSU31720" /db_xref="EnsemblGenomes-Tr:CAB15160" /db_xref="GOA:Q99039" /db_xref="InterPro:IPR012554" /db_xref="SubtiList:BG10378" /db_xref="UniProtKB/Swiss-Prot:Q99039" /translation="MEKKLEEVKQLLFRLELDIKETTDSLRNINKSIDQLDKYNYAMK IS*" /label="degQ CDS" gene complement(2775336..2775476) /gene="degQ" /locus_tag="BSU_31720" /old_locus_tag="BSU31720" /label="degQ gene" downshifts complement(2775365) /Source="Nicolas_upshifts" /id="D1639" /incds=0 /nref=2 /ntot=28 /MaxReadThrough="2.48672" /MaxDrop="4.10905" /score="21.4973657" /energy="-6.5" /TU="NA" /idTUdmin="U2470" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2775477..2775563) /Source="Nicolas_S_feature" /locus_tag="new_3257233_3257319_c" /HighExp="S2, S4, BC, M9-stat, S5, S3, S6, BT, S8, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.843" /TUlongSig="NA" /TUlongPSig="NA" /label="S1216" promotor_-10 complement(2775547..2775566) /Source="Nicolas_upshift_promotors" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2775563) /Source="Nicolas_upshifts" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2775580..2775586) /Source="Nicolas_upshift_promotors" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2775663..2775681) /Source="Nicolas_upshift_promotors" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2775673) /Source="Nicolas_upshifts" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2775696..2775702) /Source="Nicolas_upshift_promotors" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2775698..2775823 /locus_tag="BSU_31725" /old_locus_tag="BSU31725" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514001.1" /translation="MLKLRKILNLLDFNGFRIFTKQDYSPSYRIFKIEYAILGVS*" /label="hypothetical protein CDS" gene 2775698..2775823 /locus_tag="BSU_31725" /old_locus_tag="BSU31725" /label="gene" S_feature complement(2775851..2776280) /Source="Nicolas_S_feature" /locus_tag="new_3257607_3258036_c" /HighExp="LBGtran, G135, C90, Lbtran, Mt0, Lbexp, G150, G180, M40t45, C30" /AntisenseName="yuzC" /AntisenseCor="-0.77553193168722701" /AntisenseRegPval="-54.5" /CDS_PredictionProba="0.143959" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1217" promotor_-35 2775876..2775881 /Source="Nicolas_upshift_promotors" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2775893) /Source="Nicolas_upshifts" /id="D1640" /incds=0 /nref=23 /ntot=170 /MaxReadThrough="2.53578" /MaxDrop="3.52021" /score="21.4973657" /energy="-6.5" /TU="NA" /idTUdmin="U2473" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 2775896..2775914 /Source="Nicolas_upshift_promotors" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2775898 /Source="Nicolas_upshifts" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="upshifts" CDS 2775937..2776305 /gene="cotIC" /locus_tag="BSU_31730" /old_locus_tag="BSU31730" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16321932" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16321932; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391051.2" /db_xref="EnsemblGenomes-Gn:BSU31730" /db_xref="EnsemblGenomes-Tr:CAB15161" /db_xref="InterPro:IPR016559" /db_xref="SubtiList:BG14052" /db_xref="UniProtKB/Swiss-Prot:O32089" /translation="MRYRYPWFYVYPYEVRRPPAPANNIDTFIRSAKQAAGIFADAQL VLSRIAGSRELSRRILTAAEQSDKQTIRRLIKQMGVRHEVDTVFNPDGIYISLIGTQS RMILALRWSEDRNHFASIRL*" /label="cotIC CDS" gene 2775937..2776305 /gene="cotIC" /locus_tag="BSU_31730" /old_locus_tag="BSU31730" /label="cotIC gene" CDS complement(2776281..2777510) /gene="pdeH" /locus_tag="BSU_31740" /old_locus_tag="BSU31740" /EC_number="3.1.4.52" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17153922, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17153922, 23893111, 28536559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclic di-GMP phosphodiesterase" /protein_id="NP_391052.1" /db_xref="EnsemblGenomes-Gn:BSU31740" /db_xref="EnsemblGenomes-Tr:CAB15162" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR013976" /db_xref="InterPro:IPR014408" /db_xref="InterPro:IPR035919" /db_xref="SubtiList:BG10377" /db_xref="UniProtKB/Swiss-Prot:P14203" /translation="MRVFVARQPIFNRKEQVVAYELLYRESEENVYSAKDGDQATTDL VINSFLNIGIEKLTEGKRCFVNFTESLMFSNLPTSFNPKQLVIEILEDIPITPALISR CKELKKMGYMLALDDFYAINPQDEDLLEKLMSYIDILKIDFLKTTRMERRTILQTYGC RGLIFLAEKVETRKEYKQAVQDGFQLFQGYFFSEPRIISGHDLSTHFYSYYELLNELS KEQPNIKRVTEYIERDLSLSYQILKFLNSSHSRLSQKIESIQQAIMLLGFNEIKRWIY ILSFKDLSRKGHSSKHEIIKISLIRAKLCELLARKTSRPQPASYMLIGMFSLIDTLLH REIEEIVQELPLKDEVGQALLGHQNDYYQMLELVKLIESNNWDTCSELGNQLDKEEAY ECYLEALEWCHNLMDAK*" /label="pdeH CDS" gene complement(2776281..2777510) /gene="pdeH" /locus_tag="BSU_31740" /old_locus_tag="BSU31740" /label="pdeH gene" S_feature 2776306..2777619 /Source="Nicolas_S_feature" /locus_tag="new_3258062_3259375" /HighExp="S4, S5, S3, S6, LoTm, S8, S7, T5.0H, B36, Pyr" /AntisenseName="yuxH" /AntisenseCor="-0.78363066752642896" /AntisenseRegPval="-56.4" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1218" promotor_-10 complement(2777545..2777564) /Source="Nicolas_upshift_promotors" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2777564) /Source="Nicolas_upshifts" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="upshifts" downshifts 2777577 /Source="Nicolas_upshifts" /id="D1641" /incds=0 /nref=6 /ntot=30 /MaxReadThrough="1.76106" /MaxDrop="4.58543" /score="22.3133759" /energy="-13.3" /TU="NA" /idTUdmin="U2472" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(2777579..2777586) /Source="Nicolas_upshift_promotors" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2777647..2779119) /gene="pncB" /locus_tag="BSU_31750" /old_locus_tag="BSU31750" /EC_number="6.3.4.21" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 4296374, 12682299, 16199587, 24564896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate phosphoribosyltransferase" /protein_id="NP_391053.1" /db_xref="EnsemblGenomes-Gn:BSU31750" /db_xref="EnsemblGenomes-Tr:CAB15163" /db_xref="GOA:O32090" /db_xref="InterPro:IPR006405" /db_xref="InterPro:IPR007229" /db_xref="InterPro:IPR036068" /db_xref="SubtiList:BG13966" /db_xref="UniProtKB/Swiss-Prot:O32090" /translation="MLEYGFKDDSLSLHTDLYQINMAETYWRDGIHEKKAIFELFFRR LPFENGYAVFAGLEKAIEYLENFKFTDSDLSYLQDELGYHEDFIEYLRGLSFTGSLYS MKEGELVFNNEPIMRVEAPLVEAQLIETALLNIVNYQTLIATKAARIKGVIGDEVALE FGTRRAHEMDAAMWGARAALIGGFSATSNVRAGKRFNIPVSGTHAHALVQAYRDEYTA FKKYAETHKDCVFLVDTYDTLRSGMPNAIRVAKEFGDRINFIGIRLDSGDLAYLSKKA RKMLDEAGFTDAKVIASSDLDEHTIMNLKAQGARIDVWGVGTKLITAYDQPALGAVYK LVAIEEDGKMVDTIKISSNPEKVTTPGRKKVYRIINQSNHHSEGDYIALYDEQVNDQK RLRMFHPVHTFISKFVTNFYAKDLHELIFEKGILCYQNPEISDIQQYVQDNLSLLWEE YKRISKPEEYPVDLSEDCWSNKMQRIHEVKSRIEEELEEE*" /label="pncB CDS" gene complement(2777647..2779119) /gene="pncB" /locus_tag="BSU_31750" /old_locus_tag="BSU31750" /label="pncB gene" downshifts complement(2777657) /Source="Nicolas_upshifts" /id="D1642" /incds=0 /nref=200 /ntot=267 /MaxReadThrough="4.08676" /MaxDrop="6.72747" /score="16.2382739" /energy="-14.5" /TU="NA" /idTUdmin="U2475" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" misc_feature 2779000..2779004 /Source="Nicolas_upshift_promotors" /id="U2474" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.992007992007992" /psig="0.000999000999001" /xcortree=45 /SigmaFactorBS="tccaagcccgcaaatacggcatagccattttcaaacggaagc cttctgaaaaaCAGCTcaaaaatcgctttcttttcatgaatgccgtctctccagtacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2779007 /Source="Nicolas_upshifts" /id="U2474" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.992007992007992" /psig="0.000999000999001" /xcortree=45 /SigmaFactorBS="tccaagcccgcaaatacggcatagccattttcaaacggaagc cttctgaaaaaCAGCTcaaaaatcgctttcttttcatgaatgccgtctctccagtacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2779117 /Source="Nicolas_upshifts" /id="D1643" /incds=0 /nref=1 /ntot=123 /MaxReadThrough="1.2059" /MaxDrop="3.08208" /score="22.3133759" /energy="-13.3" /TU="NA" /idTUdmin="U2472" /TUdmin=1540 /isTUend="FALSE" /label="downshifts" CDS complement(2779135..2779686) /gene="pncA" /locus_tag="BSU_31760" /old_locus_tag="BSU31760" /EC_number="3.5.1.19" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15135535, 17382284, 18616465, 24340054, 24512664; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinamidase; NAD salvage pathway" /protein_id="NP_391054.1" /db_xref="EnsemblGenomes-Gn:BSU31760" /db_xref="EnsemblGenomes-Tr:CAB15164" /db_xref="GOA:O32091" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG13965" /db_xref="UniProtKB/Swiss-Prot:O32091" /translation="MKKALICIDYTNDFVASDGKLTCGEPGRMIEEAIVNLTKEFITN GDYVVLAVDSHDEGDQYHPETRLFPPHNIKGTEGKDLYGKLLPLYQKHEHEPNVYYME KTRYSAFAGTDLELKLRERQIGELHLAGVCTDICVLHTAVDAYNKGFRIVVHKQAVAS FNQEGHAWALSHFANSIGAQVAE*" /label="pncA CDS" gene complement(2779135..2779686) /gene="pncA" /locus_tag="BSU_31760" /old_locus_tag="BSU31760" /label="pncA gene" promotor_-10 complement(2779708..2779727) /Source="Nicolas_upshift_promotors" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2779721) /Source="Nicolas_upshifts" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2779740..2779747) /Source="Nicolas_upshift_promotors" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2779783..2780181) /gene="yueI" /locus_tag="BSU_31770" /old_locus_tag="BSU31770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391055.1" /db_xref="EnsemblGenomes-Gn:BSU31770" /db_xref="EnsemblGenomes-Tr:CAB15165" /db_xref="InterPro:IPR012543" /db_xref="InterPro:IPR029064" /db_xref="PDB:2OHW" /db_xref="SubtiList:BG13964" /db_xref="UniProtKB/Swiss-Prot:O32092" /translation="MSEDKMDLYLQQGMYGPLETKPDERHLFLGSLRERVVLALTKGQ VLRSKPYKEAEHELKNSHNVTLLINGELQYQSYSSYIQMASRYGVPFKIVSDLQFHTP LGIVIAADIAVNRELIYIQDDIYNRSVLKS*" /label="yueI CDS" gene complement(2779783..2780181) /gene="yueI" /locus_tag="BSU_31770" /old_locus_tag="BSU31770" /label="yueI gene" S_feature complement(2780182..2780252) /Source="Nicolas_S_feature" /locus_tag="new_3261938_3262008_c" /HighExp="Etha, dia5, Diami, dia15, H2O2, LBGtran, LPhT, G135, G180, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.998" /label="S1219" CDS complement(2780253..2780501) /gene="yueH" /locus_tag="BSU_31780" /old_locus_tag="BSU31780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391056.1" /db_xref="EnsemblGenomes-Gn:BSU31780" /db_xref="EnsemblGenomes-Tr:CAB15166" /db_xref="InterPro:IPR020260" /db_xref="SubtiList:BG13963" /db_xref="UniProtKB/Swiss-Prot:O32093" /translation="MKIRKANINTQTGMITDVYLHENRKELRTLVAVPQLEWSTIISY EEDKATLPERLEASLRRHTEETPAGELAKKIIHWVTEM*" /label="yueH CDS" gene complement(2780253..2780501) /gene="yueH" /locus_tag="BSU_31780" /old_locus_tag="BSU31780" /label="yueH gene" promotor_-10 complement(2780524..2780543) /Source="Nicolas_upshift_promotors" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2780535) /Source="Nicolas_upshifts" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2780559..2780562) /Source="Nicolas_upshift_promotors" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2780574..2780795) /gene="yueG" /locus_tag="BSU_31790" /old_locus_tag="BSU31790" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_391057.1" /db_xref="EnsemblGenomes-Gn:BSU31790" /db_xref="EnsemblGenomes-Tr:CAB15167" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13962" /db_xref="UniProtKB/Swiss-Prot:O32094" /translation="MPAIVGPIYIMSVTDNAAASFGDVFAISPKSVAHSGAGSGTFQL GDFVKINNQTSKTLFKDADITDETVSFNG*" /label="yueG CDS" gene complement(2780574..2780795) /gene="yueG" /locus_tag="BSU_31790" /old_locus_tag="BSU31790" /label="yueG gene" downshifts complement(2780601) /Source="Nicolas_upshifts" /id="D1644" /incds=0 /nref=11 /ntot=31 /MaxReadThrough="3.65047" /MaxDrop="4.3681" /score="19.032155" /energy="-12.6" /TU="U2477,U2479,U2482" /idTUdmin="U2482" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 2780789 /Source="Nicolas_upshifts" /id="D1645" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="1.17049" /MaxDrop="3.0193" /score="-7.47675224" /energy="-6.7" /TU="NA" /idTUdmin="U2480" /TUdmin="-1320" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2780813..2780832) /Source="Nicolas_upshift_promotors" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2780819) /Source="Nicolas_upshifts" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2780845..2780854) /Source="Nicolas_upshift_promotors" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2780855..2781964) /gene="yueF" /locus_tag="BSU_31800" /old_locus_tag="BSU31800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391058.1" /db_xref="EnsemblGenomes-Gn:BSU31800" /db_xref="EnsemblGenomes-Tr:CAB15168" /db_xref="GOA:O32095" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13961" /db_xref="UniProtKB/Swiss-Prot:O32095" /translation="MLKSKVHFWTLQILFVLLIIFVATKVSFVFQPFIVFISTLFFPM LIAGILYFIFNPVVRLLEKKIPRTLSILLIYLLFIGLLAFISASVGPIITAQVTGLFN NLPDYIKQIQALTKDLSHSQWFTWMMNQDYVSISKIEQSLTSFLQNLPQNITSSLSAV FGVVTNITLVIITVPFILFYMLKDGHRFPHLAVKILPASYRTEGLKIFKDLSDTLAAY FQGQLLICLFVGTACFIGYLIAGLPYALILGIVMAITNIIPYVGPFLGAAPAVIVGFM DSPAKALFAIIVVVIVQQLDGNLLSPLVIGKRLNTHPLTIILLLIGAGSFGGILGMIL AVPVYAVVKAFFLNIVRLIKLRQRSRLEENAKPAE*" /label="yueF CDS" gene complement(2780855..2781964) /gene="yueF" /locus_tag="BSU_31800" /old_locus_tag="BSU31800" /label="yueF gene" promotor_-35 2781616..2781623 /Source="Nicolas_upshift_promotors" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2781638..2781657 /Source="Nicolas_upshift_promotors" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2781647..2782041 /Source="Nicolas_S_feature" /locus_tag="new_3263403_3263797" /HighExp="dia15, S8, H2O2, dia5, LBGstat, Paraq, C30, S7, Diami, G180" /AntisenseName="yueF" /AntisenseCor="0.28555063485711402" /AntisenseRegPval="-5.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1220" upshifts 2781647 /Source="Nicolas_upshifts" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2782012..2782031) /Source="Nicolas_upshift_promotors" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="promotor_-10" upshifts complement(2782028) /Source="Nicolas_upshifts" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="upshifts" S_feature complement(2782030..2782470) /Source="Nicolas_S_feature" /locus_tag="new_3263786_3264226_c" /HighExp="Diami, S8, H2O2, S7, C90, Paraq, Salt, S1, dia15, dia5" /AntisenseName="yuzE" /AntisenseCor="0.47136608606324898" /AntisenseRegPval="-15.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1221" promotor_-35 2782033..2782035 /Source="Nicolas_upshift_promotors" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2782043 /Source="Nicolas_upshifts" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2782045..2782050) /Source="Nicolas_upshift_promotors" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="promotor_-35" promotor_-10 2782051..2782070 /Source="Nicolas_upshift_promotors" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2782079..2782468 /gene="yuzE" /locus_tag="BSU_31810" /old_locus_tag="BSU31810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391059.1" /db_xref="EnsemblGenomes-Gn:BSU31810" /db_xref="EnsemblGenomes-Tr:CAB15169" /db_xref="InterPro:IPR016789" /db_xref="InterPro:IPR019270" /db_xref="SubtiList:BG14054" /db_xref="UniProtKB/Swiss-Prot:O32096" /translation="MKAVTYDTDSELAYIYVLPPKKNRNVRTEELRVNDCLLLDISQD GKIAGFECFGEAAHLCAPFAGKSRLYVKDSDGYHFRVCQHASVRSCYTVYRVTFCFSD GDYQEFAGFDLDGTMYHSAFLQRLTEK*" /label="yuzE CDS" gene 2782079..2782468 /gene="yuzE" /locus_tag="BSU_31810" /old_locus_tag="BSU31810" /label="yuzE gene" CDS complement(2782509..2782745) /gene="yuzF" /locus_tag="BSU_31820" /old_locus_tag="BSU31820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391060.1" /db_xref="EnsemblGenomes-Gn:BSU31820" /db_xref="EnsemblGenomes-Tr:CAB15170" /db_xref="InterPro:IPR020139" /db_xref="SubtiList:BG14055" /db_xref="UniProtKB/Swiss-Prot:O32097" /translation="MVNQGSPQLVSLVDPYVYQTIKKLIGSRFVIQTVRDTVRGRLID VKPDHITIEGARNSVCLIRIQHMISVTPDYSERV*" /label="yuzF CDS" gene complement(2782509..2782745) /gene="yuzF" /locus_tag="BSU_31820" /old_locus_tag="BSU31820" /label="yuzF gene" downshifts complement(2782515) /Source="Nicolas_upshifts" /id="D1646" /incds=0 /nref=12 /ntot=37 /MaxReadThrough="5.19136" /MaxDrop="5.1675" /score="30.7642328" /energy="-9.9" /TU="U2482" /idTUdmin="U2481" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2782765..2782784) /Source="Nicolas_upshift_promotors" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2782779) /Source="Nicolas_upshifts" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2782781..2782921) /Source="Nicolas_S_feature" /locus_tag="new_3264537_3264677_c" /HighExp="BT, Diami, S8, Etha, Sw, C90, Salt, B36, LPhT, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.998, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1222" promotor_-35 complement(2782798..2782807) /Source="Nicolas_upshift_promotors" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2782922..2783452) /gene="yueE" /locus_tag="BSU_31830" /old_locus_tag="BSU31830" /EC_number="3.-.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent phosphohydrolase" /protein_id="NP_391061.1" /db_xref="EnsemblGenomes-Gn:BSU31830" /db_xref="EnsemblGenomes-Tr:CAB15171" /db_xref="GOA:O32098" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="SubtiList:BG13960" /db_xref="UniProtKB/Swiss-Prot:O32098" /translation="MRKVTLMDVFTHPIAQKYLQRSGVAHAIACAYHAYRLSVKADIN PDLAAKAALLHDIGHYEWYTDGKWDYEKYKRNDIHAIKGAERAHKLLIRLGEEPKAAK EIALAILLHTDSYLPEGELDKNTLQQIVKKADELDEEPGGHHHYRQIDPSTARKKIEK LDQLIDQAQASVIKPV*" /label="yueE CDS" gene complement(2782922..2783452) /gene="yueE" /locus_tag="BSU_31830" /old_locus_tag="BSU31830" /label="yueE gene" promotor_-10 complement(2783472..2783491) /Source="Nicolas_upshift_promotors" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="promotor_-10" upshifts complement(2783483) /Source="Nicolas_upshifts" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="upshifts" S_feature complement(2783485..2783571) /Source="Nicolas_S_feature" /locus_tag="new_3265241_3265327_c" /HighExp="BT, S8, S6, S7, B36, Etha, S5, S4, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1223" promotor_-35 complement(2783503..2783511) /Source="Nicolas_upshift_promotors" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="promotor_-35" promotor_-10 complement(2783566..2783585) /Source="Nicolas_upshift_promotors" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2783573) /Source="Nicolas_upshifts" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2783599..2783608) /Source="Nicolas_upshift_promotors" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2783650..2784381) /gene="bznD" /locus_tag="BSU_31840" /old_locus_tag="BSU31840" /EC_number="1.1.1.320" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11745140, 21670841; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="benzil reductase (benzoin forming)" /protein_id="NP_391062.1" /db_xref="EnsemblGenomes-Gn:BSU31840" /db_xref="EnsemblGenomes-Tr:CAB15172" /db_xref="GOA:O32099" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13959" /db_xref="UniProtKB/Swiss-Prot:O32099" /translation="MELYIITGASKGLGQAIALQALEKGHEVHALSRTKTDVSHKKLT QHQIDLINLEEAEQQFETLLSSIDSDRYSGITLINNAGMVTPIKRAGEASLDELQRHY QLNLTAPVLLSQLFTKRFASYSGKKTVVNITSGAAKNPYKGWSAYCSSKAGLDMFTRT FGFEQEDEELPVNMISFSPGVMDTEMQAVIRSSSKKDFHHIERFRKLNETGSLRSPDF IAGTLLSLLEKGTENGRIYDIKEFL*" /label="bznD CDS" gene complement(2783650..2784381) /gene="bznD" /locus_tag="BSU_31840" /old_locus_tag="BSU31840" /label="bznD gene" downshifts complement(2783680) /Source="Nicolas_upshifts" /id="D1647" /incds=0 /nref=183 /ntot=253 /MaxReadThrough="2.76356" /MaxDrop="5.18507" /score="30.7642328" /energy="-9.9" /TU="NA" /idTUdmin="U2484" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2784396..2784415) /Source="Nicolas_upshift_promotors" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2784407) /Source="Nicolas_upshifts" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2784430..2784437) /Source="Nicolas_upshift_promotors" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2784444..2784899) /gene="yueC" /locus_tag="BSU_31850" /old_locus_tag="BSU31850" /function="11.1: Protein and peptide secretion and trafficking" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YueC protein" /protein_id="NP_391063.1" /db_xref="EnsemblGenomes-Gn:BSU31850" /db_xref="EnsemblGenomes-Tr:CAB15173" /db_xref="GOA:O32100" /db_xref="InterPro:IPR018920" /db_xref="InterPro:IPR020212" /db_xref="SubtiList:BG13958" /db_xref="UniProtKB/Swiss-Prot:O32100" /translation="MLSFSLFIPSAAAAQTEENTDVAPNQYEKKDIEIDTNYLHEDTY YEEKTELPEEQKDITFDKPKDKDAELIKDLFTSTNAEDSNTIAAQSKQLGITFAEKPM TKTSSTETEDEQETSSLLLPMIYVVLILLGIAGIVFLIPKVTAQENKKA*" /label="yueC CDS" gene complement(2784444..2784899) /gene="yueC" /locus_tag="BSU_31850" /old_locus_tag="BSU31850" /label="yueC gene" promotor_-35 2784852..2784858 /Source="Nicolas_upshift_promotors" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2784873..2784891 /Source="Nicolas_upshift_promotors" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2784881..2787248 /Source="Nicolas_S_feature" /locus_tag="new_3266637_3269004" /HighExp="Etha, Gly, Sw, Salt, LoTm, C30, BT, HiTm, Mal, G135" /AntisenseName="yueB" /AntisenseCor="-9.3455707286730305E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1224" upshifts 2784881 /Source="Nicolas_upshifts" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2784931..2788161) /gene="yueB" /locus_tag="BSU_31860" /old_locus_tag="BSU31860" /function="11.1: Protein and peptide secretion and trafficking" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022, 27179995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022, 27179995; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system; calcium-dependent phage SPP1 attachment site" /protein_id="NP_391064.1" /db_xref="EnsemblGenomes-Gn:BSU31860" /db_xref="EnsemblGenomes-Tr:CAB15174" /db_xref="GOA:O32101" /db_xref="InterPro:IPR023838" /db_xref="SubtiList:BG13957" /db_xref="UniProtKB/Swiss-Prot:O32101" /translation="MTEQRKSLIKLISAVIIILLLPVLFFRFIGDDPTKKAVNSTRQI AVVNEDTGVLSDEVKSDEEDKSAQFGKEVAAVLGERPDYSWTVVNRSAAETGLASKKY DAIVYIPSDFSKNILSYDKDHPQKATLEFSIQDNLNAVNKEKVQRELEDAQKTMNKKM SALYWNFVSQKVDNIRGEFDKIVNKESEFQNVMYNFYKPSSNDLAGEIKQQKDLIDEL KKSMNEAQGTTKEKASTAEEAKNTLKEFIDTVERYKEYQENQKKLLLAAQDSTQQQIR TGLDAIQAQQKANQFSERMSGLATGIGQAKTQIGLTNLALNNAEKLRQNQVPLQEMGM KKIENDMFNAFLSRYKSQYEAIKYQNLNQLQENIGKNRLSLLKPKESDEKEDGEDTSD NKDDTDKEDIEDIKLDLEKQRDELKNVATEIKDISEGLKEPEQEKPTTPDAEEPSTDD SPNTEEPSNDIPTSDDQPTNEDTGSSEEGTQDNGSQNDVQTNIETGQKHQESSKNVPE QDTNTENTGTSKTDFSLIELADENDGSNQSDGLQGDGADGETDISGAKKRLNEAAIKL EEIENALQEKQEEHNNKLEKHIDELNQEIKELNKTVSKLNDQIGDLTKKLVDFDNNVN DAYRLIYNLEDEIIQTLQSRGYIDQKEKLSSIFSSRIETDNISNLMKYYNSLNLYKST LNDNLDLGSLTIIKGEVIQEQDGNVQSVLALTPEESASWEALKNNTMQTDEDINSFID GMTKFADDYSGYIRDSQAGVLDELTKISESAAKASEQLVTGATQESATFSNDGLSGTM ALSVQDTVGQEVLQMSDMMGSLSDRQSGIIDYTTNMQQSVNDVQAKADTLNNNWGKNV ASTKLVRNDVYGILGNTLVDGQNNGYVYDYLANPLKISGEVPEEKIQTVPPVVILVIV LISSLLIGYFSSYYQNAPLLVKGALFGILNILVGLMISLFGLNIYSLPDDQTIKWSVF TILLLVASSAFIRTAFRFGSIPGWVASAAMILFYVAPLIDLIMPNFTFEDPVSKVYID IQYGTGHLFTMGITVLLIITVIAVALPLIIRLMAEHTAESDETYEA*" /label="yueB CDS" gene complement(2784931..2788161) /gene="yueB" /locus_tag="BSU_31860" /old_locus_tag="BSU31860" /label="yueB gene" CDS complement(2788158..2792645) /gene="yukAB" /locus_tag="BSU_31875" /old_locus_tag="BSU31875" /function="11.1: Protein and peptide secretion and trafficking" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system FtsK/SpoIIIE family ATPase" /protein_id="NP_391066.2" /db_xref="EnsemblGenomes-Gn:BSU31875" /db_xref="EnsemblGenomes-Tr:CAB15176" /db_xref="GOA:C0SPA7" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR022206" /db_xref="InterPro:IPR023839" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12375" /db_xref="UniProtKB/Swiss-Prot:C0SPA7" /translation="MSLLWVFYQNNVQKLNLSNLPSSHPVTIGPDVKDSVTISTIPFN SGVISLKRKESGGQYEVFLGNDCLGTIETDISFTLQTDQQDIRLILTGSEPEKSVYFT GNRDEIVCSSEKTNADIYLNPQDFAFAEQSTFSLLRAGGSWSVRPESGTIFLNGEKIN ANTPLKPGDEIFWNFTQMRVTEQDLLEIVHYAQFETALTETVKPSTEMQKKYPQYRRT PRMVYDLPDDRVSFSFPSQESDQTNRGLWLVILPPLVMLIVMGVVAIIQPRGIFILVS LAMFMMTLITSTVQYFRDKNQRKKREEKRERVYKLYLDNKRKELQALAEKQKQVLEFH FPSFEQMKYLTSEISDRIWEKSLESKDYLQLRLGTGTVPSSYEINMSGGDLANRDIDD LMEKSQHMQRVYKDIRNAPVTVDLAEGPMGLVGKSQIVKNEIHQLIGQLSFFNSYHDL RFVFIFHEEEYKDWEWMKWLPQFQMPHIYAKGFIYNEQTRDQLLSSLYELIRERDLED DKEKLQFKPHFVFVITNQQLISEHVILEYLEGQHEHLGISTIVAAETKESLSENITTL VRYINEHEGDILIQKKKAVRIPFRLDHHQREDNERFSRTLRTLNHQVGITNSIPETVS FLELFHAKEVKEIGIQQRWLTSESSKSLSVPIGYKGKDDIVYLNLHEKAHGPHGLLAG TTGSGKSEFLQTYILSLAVHFHPHEAAFLLIDYKGGGMAQPFRNIPHLLGTITNIEGS KNFSMRALASIKSELKKRQRLFDQYQVNHINDYTKLYKQGKAEVAMPHLFLISDEFAE LKSEEPDFIRELVSAARIGRSLGVHLILATQKPGGIIDDQIWSNSRFKVALKVQDATD SKEILKNSDAANITVTGRGYLQVGNNEVYELFQSAWSGAPYLEEVYGTEDEIAIVTDT GLIPLSEVDTEDNAKKDVQTEIEAVVDEIERIQDEMGIEKLPSPWLPPLAERIPRTLF PSNEKDHFHFAYVDEPDLQRQAPIAYKMMEDGNIGIFGSSGYGKSIAAATFLMSFADV YTPEELHVYIFDFGNGTLLPLAKLPHTADYFLMDQSRKIEKFMIRIKEEIDRRKRLFR EKEISHIKMYNALSEEELPFIFITIDNFDIVKDEMHELESEFVQLSRDGQSLGIYFML TATRVNAVRQSLLNNLKTKIVHYLMDQSEGYSIYGRPKFNLEPIPGRVIIQKEELYFA QMFLPVDADDDIGMFNELKSDVQKLQGRFASMEQPAPIPMLPESLSTRELSIRFKLER KPLSVPIGLHEETVSPVYFDLGKHKHCLILGQTQRGKTNVLKVMLEHLIDDETEMIGL FDSIDRGLSHYAKESDVSYLETKEDIEQWIETAEDIFKTREAMYVEAVRQGDAQNLRF SQVVLMIDGITRFQQTIDTRIQDRLANFMKSYAHLGFSFIPGGNHSEFSKGYDSLTTE MKQIRHAILLMKKSEQNVIPLPYQRQEPEIQPGFGYVVENGKEQKVQIPLCSAERESA R*" /label="yukAB CDS" gene complement(2788158..2792645) /gene="yukAB" /locus_tag="BSU_31875" /old_locus_tag="BSU31875" /label="yukAB gene" promotor_-35 2791920..2791926 /Source="Nicolas_upshift_promotors" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2791941..2791959 /Source="Nicolas_upshift_promotors" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2791947..2792909 /Source="Nicolas_S_feature" /locus_tag="new_3273703_3274665" /HighExp="Etha, Sw, Gly, Salt, B60, M9-stat, LoTm, T0.30H, BT, LPhT" /AntisenseName="yukB" /AntisenseCor="-0.26212584196591598" /AntisenseRegPval="-4.9000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1225" upshifts 2791947 /Source="Nicolas_upshifts" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2792706..2794061) /gene="yukC" /locus_tag="BSU_31890" /old_locus_tag="BSU31890" /function="11.1: Protein and peptide secretion and trafficking" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576783, 16845009, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 16845009, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YukC protein" /protein_id="NP_391067.1" /db_xref="EnsemblGenomes-Gn:BSU31890" /db_xref="EnsemblGenomes-Tr:CAB15177" /db_xref="GOA:P71070" /db_xref="InterPro:IPR018778" /db_xref="SubtiList:BG12376" /db_xref="UniProtKB/Swiss-Prot:P71070" /translation="MSGEQKSYLENQLEAVAEKTDAGYTFTFQREKIKLLDGLEANVI KDINPFFHKEIDVTDDEVIITIQPPSSYKAFRFMKAKDKKSKWQFAYQLVQAVQQHNL SRLNLIVAPENIVFDKGLTPYFLHYGVKESIPPYERDEERVWQELKAAAALAVDGAFA FEDYLKFNETLTFSAEAKAILDAESYDDLLELIQTHIDELEAKAKTYIHIPRKKWNIQ RYIGLGLIVLLVPALIYSMYALFFAQPKHQAIVDSNRAFLNKQYSEVISTLSKYDAES LPESVQYQLATSYVEVENLGSAKTKNIENNLVTLQSDPQHFLYWIDYGRGEYKEAISI GRKLEYNDYIYFALAKYKQQLLSEDTNDEDIQKELDSVNSELEKAQKERQENKQSNSE TSLVDTSEEQTQTDEEKQAEEKAAEEKAAAEEKAKKEEQKEKEDEKKETEKKDEKKDD K*" /label="yukC CDS" gene complement(2792706..2794061) /gene="yukC" /locus_tag="BSU_31890" /old_locus_tag="BSU31890" /label="yukC gene" downshifts complement(2792727) /Source="Nicolas_upshifts" /id="D1648" /incds=0 /nref=5 /ntot=116 /MaxReadThrough="6.33518" /MaxDrop="3.1562" /score="14.9475399" /energy="-16" /TU="U2488" /idTUdmin="U2496" /TUdmin=5823 /isTUend="FALSE" /label="downshifts" CDS complement(2794076..2794315) /gene="yukD" /locus_tag="BSU_31900" /old_locus_tag="BSU31900" /function="11.1: Protein and peptide secretion and trafficking" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576783, 16845009, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 16845009, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YukD protein" /protein_id="NP_391068.1" /db_xref="EnsemblGenomes-Gn:BSU31900" /db_xref="EnsemblGenomes-Tr:CAB15178" /db_xref="InterPro:IPR014921" /db_xref="InterPro:IPR024962" /db_xref="InterPro:IPR029071" /db_xref="PDB:2BPS" /db_xref="SubtiList:BG12377" /db_xref="UniProtKB/Swiss-Prot:P71071" /translation="MYIDITIDLKHYNGSVFDLRLSDYHPVKKVIDIAWQAQSVSMPP REGHWIRVVNKDKVFSGECKLSDCGITNGDRLEIL*" /label="yukD CDS" gene complement(2794076..2794315) /gene="yukD" /locus_tag="BSU_31900" /old_locus_tag="BSU31900" /label="yukD gene" CDS complement(2794385..2794678) /gene="yukE" /locus_tag="BSU_31910" /old_locus_tag="BSU31910" /function="11.1: Protein and peptide secretion and trafficking" /experiment="publication(s) with functional evidences, PMID:11973144, 15576783, 22720735, 24798022, 24828531" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11973144, 15576783, 22720735, 24798022, 24828531; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small WGX100 secreted protein (ESX-dependent secretion)" /protein_id="NP_391069.2" /db_xref="EnsemblGenomes-Gn:BSU31910" /db_xref="EnsemblGenomes-Tr:CAB15179" /db_xref="GOA:C0SP85" /db_xref="InterPro:IPR010310" /db_xref="InterPro:IPR036689" /db_xref="SubtiList:BG12378" /db_xref="UniProtKB/Swiss-Prot:C0SP85" /translation="MAGLIRVTPEELRAMAKQYGVESQEVLNQVDRLNRMISDLKSMW EGASSEAFADQYEQLKPSFIKMSDLLQDVNQQLDQTANTLESTDQDIANQIRG*" /label="yukE CDS" gene complement(2794385..2794678) /gene="yukE" /locus_tag="BSU_31910" /old_locus_tag="BSU31910" /label="yukE gene" downshifts complement(2794395) /Source="Nicolas_upshifts" /id="D1649" /incds=0 /nref=248 /ntot=268 /MaxReadThrough="6.21938" /MaxDrop="7.50121" /score="14.9475399" /energy="-16" /TU="U2488" /idTUdmin="U2496" /TUdmin=4155 /isTUend="FALSE" /label="downshifts" downshifts 2794672 /Source="Nicolas_upshifts" /id="D1650" /incds=0 /nref=1 /ntot=26 /MaxReadThrough="2.85718" /MaxDrop="3.33739" /score="43.0917981" /energy="-17.1" /TU="NA" /idTUdmin="U2487" /TUdmin="-242" /isTUend="FALSE" /label="downshifts" S_feature complement(2794679..2794757) /Source="Nicolas_S_feature" /locus_tag="new_3276435_3276513_c" /HighExp="T-1.10H, T1.0H, T-0.40H, T1.30H, BI, T2.30H, T3.0H, T-2.40H, T2.0H, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1226" promotor_-35 2794720..2794727 /Source="Nicolas_upshift_promotors" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2794737..2794756) /Source="Nicolas_upshift_promotors" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2794738 /Source="Nicolas_upshifts" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2794742..2794759 /Source="Nicolas_upshift_promotors" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2794757) /Source="Nicolas_upshifts" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2794771..2794778) /Source="Nicolas_upshift_promotors" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2794816..2794821 /Source="Nicolas_upshift_promotors" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2794836..2794855 /Source="Nicolas_upshift_promotors" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2794848..2794954 /Source="Nicolas_S_feature" /locus_tag="new_3276604_3276710" /HighExp="S8, C30, S7, S6, Pyr, Glucon, B60, LoTm, C90, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="0.523, 0.76" /TUlongSig="NA" /TUlongPSig="NA" /label="S1227" upshifts 2794848 /Source="Nicolas_upshifts" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2795023..2795029 /Source="Nicolas_upshift_promotors" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2795043..2795062 /Source="Nicolas_upshift_promotors" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2795046 /Source="Nicolas_upshifts" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2795151..2795154 /Source="Nicolas_upshift_promotors" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="promotor_-35" upshifts 2795163 /Source="Nicolas_upshifts" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="upshifts" promotor_-10 complement(2795166..2795185) /Source="Nicolas_upshift_promotors" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2795170..2795189 /Source="Nicolas_upshift_promotors" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="promotor_-10" upshifts complement(2795188) /Source="Nicolas_upshifts" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2795199..2796467 /gene="adeR" /locus_tag="BSU_31920" /old_locus_tag="BSU31920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22797752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22797752; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator (AdeR-alanine)" /protein_id="NP_391070.2" /db_xref="EnsemblGenomes-Gn:BSU31920" /db_xref="EnsemblGenomes-Tr:CAB15180" /db_xref="GOA:P71073" /db_xref="InterPro:IPR010312" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG12379" /db_xref="UniProtKB/Swiss-Prot:P71073" /translation="MSKRNQARKVGRFMTMPNDPFKYSFDRLEDVADHISDVLRCPIT IEDVNHKLLAYSTHSDCTDPARTSTIIGRRVPEKVINKLWKDGTIPALLKTDQPIRVK QIDEVGLSNRVAISIWKNKQVLGFIWALEIQKTLSDEDLLTLQMAAKAVKNKLLKLQI RKTKNEERSQEFFWKMLTGHIHQEDDMADGFHKLGMAAPSEFSVMIIRINGELTEKIE QQLQYLQETTQQVYVLLATVDSNELIILTSPKTDHPFQDLKQFALSTQKQLKERYKIE DVSIAFGGIYNSISFVSRSYQEALSVLKTKERFAEETKHLFSFSELGIYQYLDVLNEK RKQAGHYNYSLSKLEQYDRDHQSNMVETLERFIEADSNVNTASKLLNIHVNTLNYRLK RISQIAEIDLKNVNQKFTIYLDIKLRHMDL*" /label="adeR CDS" gene 2795199..2796467 /gene="adeR" /locus_tag="BSU_31920" /old_locus_tag="BSU31920" /label="adeR gene" promotor_-35 complement(2795200..2795207) /Source="Nicolas_upshift_promotors" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2796527..2796546 /Source="Nicolas_upshift_promotors" /id="U2493" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.696303696303696" /psig="0.996003996003996" /xcortree=1594 /SigmaFactorBS="tcacaaatccatgtttttttattttcttaatcaaacaaagaa ttttccaaaatatCAAGCTACACTAAAAATATCacatatacaggaggagacagatatg a" /listShort="ald, yukJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2796532 /Source="Nicolas_upshifts" /id="U2493" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.696303696303696" /psig="0.996003996003996" /xcortree=1594 /SigmaFactorBS="tcacaaatccatgtttttttattttcttaatcaaacaaagaa ttttccaaaatatCAAGCTACACTAAAAATATCacatatacaggaggagacagatatg a" /listShort="ald, yukJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2796569..2797705 /gene="ald" /locus_tag="BSU_31930" /old_locus_tag="BSU31930" /EC_number="1.4.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:488097, 8226620, 22720735, 22797752, 26202482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 488097, 8226620, 22720735, 22797752, 26202482; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-alanine dehydrogenase (NAD-dependent)" /protein_id="NP_391071.1" /db_xref="EnsemblGenomes-Gn:BSU31930" /db_xref="EnsemblGenomes-Tr:CAB15181" /db_xref="GOA:Q08352" /db_xref="InterPro:IPR007698" /db_xref="InterPro:IPR007886" /db_xref="InterPro:IPR008141" /db_xref="InterPro:IPR008142" /db_xref="InterPro:IPR008143" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10468" /db_xref="UniProtKB/Swiss-Prot:Q08352" /translation="MIIGVPKEIKNNENRVALTPGGVSQLISNGHRVLVETGAGLGSG FENEAYESAGAEIIADPKQVWDAEMVMKVKEPLPEEYVYFRKGLVLFTYLHLAAEPEL AQALKDKGVTAIAYETVSEGRTLPLLTPMSEVAGRMAAQIGAQFLEKPKGGKGILLAG VPGVSRGKVTIIGGGVVGTNAAKMAVGLGADVTIIDLNADRLRQLDDIFGHQIKTLIS NPVNIADAVAEADLLICAVLIPGAKAPTLVTEEMVKQMKPGSVIVDVAIDQGGIVETV DHITTHDQPTYEKHGVVHYAVANMPGAVPRTSTIALTNVTVPYALQIANKGAVKALAD NTALRAGLNTANGHVTYEAVARDLGYEYVPAEKALQDESSVAGA*" /label="ald CDS" gene 2796569..2797705 /gene="ald" /locus_tag="BSU_31930" /old_locus_tag="BSU31930" /label="ald gene" downshifts 2797705 /Source="Nicolas_upshifts" /id="D1651" /incds=0 /nref=42 /ntot=190 /MaxReadThrough="5.86626" /MaxDrop="4.4689" /score="41.2794059" /energy="-14.2" /TU="U2493" /idTUdmin="U2493" /TUdmin="-769" /isTUend="FALSE" /label="downshifts" promotor_-35 2797754..2797762 /Source="Nicolas_upshift_promotors" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2797772 /Source="Nicolas_upshifts" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2797774..2797792 /Source="Nicolas_upshift_promotors" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2797817..2798494 /gene="yukJ" /locus_tag="BSU_31945" /old_locus_tag="BSU31945" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391073.2" /db_xref="EnsemblGenomes-Gn:BSU31945" /db_xref="EnsemblGenomes-Tr:CAB15183" /db_xref="InterPro:IPR019268" /db_xref="SubtiList:BG12380" /db_xref="UniProtKB/Swiss-Prot:C0SPB1" /translation="MAVQQYGVLKGIVLDMKRETDDDSPHFQVKMLGEENTYYRCAIN VMSSSEESEVLYLADDQFDSGSITILPNMPYGYTRINEANREVALDYVRGNLFDPREM KPLPHEITGPDNDLNDFIETYMKKAQDEKTPVYIFGSKFGPEQAADKIFGFTPTNGMH NIHMNQGNAMDTRWKKDNGSWHDGGILIQFADQWAAVFLAFLSQSWCTDENGNPVRDC DHTQTSA*" /label="yukJ CDS" gene 2797817..2798494 /gene="yukJ" /locus_tag="BSU_31945" /old_locus_tag="BSU31945" /label="yukJ gene" downshifts 2798478 /Source="Nicolas_upshifts" /id="D1652" /incds=0 /nref=37 /ntot=185 /MaxReadThrough="3.39608" /MaxDrop="5.40829" /score="9.49891506" /energy="-12" /TU="U2494" /idTUdmin="U2493" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(2798538..2798747) /gene="mbtH" /locus_tag="BSU_31959" /old_locus_tag="BSU31959" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11112781, 20845982, 21890635, 24975514, 28880538; Product type r: regulator" /codon_start=1 /transl_table=11 /product="stimulator of DhbF tyrosine adenylation activity" /protein_id="YP_003097779.1" /db_xref="EnsemblGenomes-Gn:BSU31959" /db_xref="EnsemblGenomes-Tr:CAX52685" /db_xref="InterPro:IPR005153" /db_xref="UniProtKB/Swiss-Prot:C0H3Q6" /translation="MANPFENADGTYLVLVNEEGQYSLWPGFIDVPSGWTVVHEQKGR EACLDYIQSHWSDMRPNSLKTVENV*" /label="mbtH CDS" gene complement(2798538..2798747) /gene="mbtH" /locus_tag="BSU_31959" /old_locus_tag="BSU31959" /label="mbtH gene" downshifts complement(2798550) /Source="Nicolas_upshifts" /id="D1653" /incds=0 /nref=106 /ntot=174 /MaxReadThrough="1.39981" /MaxDrop="6.23998" /score="17.380299" /energy="-12" /TU="NA" /idTUdmin="U2496" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2798763..2805899) /gene="dhbF" /locus_tag="BSU_31960" /old_locus_tag="BSU31960" /EC_number="2.7.7.-" /EC_number="5.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11112781, 12354229, 16672620, 18957859, 26284661, 27731335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11112781, 12354229, 16672620, 18957859, 26284661, 27731335; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="siderophore 2,3-dihydroxybenzoate-glycine-threonine trimeric ester bacillibactin synthetase" /protein_id="NP_391076.3" /db_xref="EnsemblGenomes-Gn:BSU31960" /db_xref="EnsemblGenomes-Tr:CAB15186" /db_xref="GOA:P45745" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020802" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11243" /db_xref="UniProtKB/Swiss-Prot:P45745" /translation="MPDTKDLQYSLTGAQTGIWFAQQLDPDNPIYNTAEYIEINGPVN IALFEEALRHVIKEAESLHVRFGENMDGPWQMINPSPDVQLHVIDVSSEPDPEKTALN WMKADLAKPVDLGYAPLFNEALFIAGPDRFFWYQRIHHIAIDGFGFSLIAQRVASTYT ALIKGQTAKSRSFGSLQAILEEDTDYRGSEQYEKDRQFWLDRFADAPEVVSLADRAPR TSNSFLRHTAYLPPSDVNALKEAARYFSGSWHEVMIAVSAVYVHRMTGSEDVVLGLPM MGRIGSASLNVPAMVMNLLPLRLTVSSSMSFSELIQQISREIRSIRRHHKYRHEELRR DLKLIGENHRLFGPQINLMPFDYGLDFAGVRGTTHNLSAGPVDDLSINVYDRTDGSGL RIDVDANPEVYSESDIKLHQQRILQLLQTASAGEDMLIGQMELLLPEEKEKVISKWNE TAKSEKLVSLQDMFEKQAVLTPERIALMCDDIQVNYRKLNEEANRLARLLIEKGIGPE QFVALALPRSPEMVASMLGVLKTGAAYLPLDPEFPADRISYMLEDAKPSCIITTEEIA ASLPDDLAVPELVLDQAVTQEIIKRYSPENQDVSVSLDHPAYIIYTSGSTGRPKGVVV TQKSLSNFLLSMQEAFSLGEEDRLLAVTTVAFDISALELYLPLISGAQIVIAKKETIR EPQALAQMIENFDINIMQATPTLWHALVTSEPEKLRGLRVLVGGEALPSGLLQELQDL HCSVTNLYGPTETTIWSAAAFLEEGLKGVPPIGKPIWNTQVYVLDNGLQPVPPGVVGE LYIAGTGLARGYFHRPDLTAERFVADPYGPPGTRMYRTGDQARWRADGSLDYIGRADH QIKIRGFRIELGEIDAVLANHPHIEQAAVVVREDQPGDKRLAAYVVADAAIDTAELRR YMGASLPDYMVPSAFVEMDELPLTPNGKLDRKALPAPDFSTSVSDRAPRTPQEEILCD LFAEVLGLARVGIDDSFFELGGHSLLAARLMSRIREVMGAELGIAKLFDEPTVAGLAA HLDLAQSACPALQRAERPEKIPLSFAQRRLWFLHCLEGPSPTYNIPVAVRLSGELDQG LLKAALYDLVCRHESLRTIFPESQGTSYQHILDADRACPELHVTEIAEKELSDRLAEA VRYSFDLAAEPAFRAELFVIGPDEYVLLLLVHHIVGDGWSLTPLTRDLGTAYAARCHG RSPEWAPLAVQYADYALWQQELLGNEDDPNSLIAGQLAFWKETLKNLPDQLELPTDYS RPAEPSHDGDTIHFRIEPEFHKRLQELARANRVSLFMVLQSGLAALLTRLGAGTDIPI GSPIAGRNDDALGDLVGLFINTLVLRTDTSGDPSFRELLDRVREVNLAAYDNQDLPFE RLVEVLNPARSRATHPLFQIMLAFQNTPDAELHLPDMESSLRINSVGSAKFDLTLEIS EDRLADGTPNGMEGLLEYSTDLFKRETAQALADRLMRLLEAAESDPDEQIGNLDILAP EEHSSMVTDWQSVSEKIPHACLPEQFEKQAALRPDAIAVVYENQELSYAELNERANRL ARMMISEGVGPEQFVALALPRSLEMAVGLLAVLKAGAAYLPLDPDYPADRIAFMLKDA QPAFIMTNTKAANHIPPVENVPKIVLDDPELAEKLNTYPAGNPKNKDRTQPLSPLNTA YVIYTSGSTGVPKGVMIPHQNVTRLFAATEHWFRFSSGDIWTMFHSYAFDFSVWEIWG PLLHGGRLVIVPHHVSRSPEAFLRLLVKEGVTVLNQTPSAFYQFMQAEREQPDLGQAL SLRYVIFGGEALELSRLEDWYNRHPENRPQLINMYGITETTVHVSYIELDRSMAALRA NSLIGCGIPDLGVYVLDERLQPVPPGVAGELYVSGAGLARGYLGRPGLTSERFIADPF GPPGTRMYRTGDVARLRADGSLDYVGRADHQVKIRGFRIELGEIEAALVQHPQLEDAA VIVREDQPGDKRLAAYVIPSEETFDTAELRRYAAERLPDYMVPAAFVTMKELPLTPNG KLDRKALPAPDFAAAVTGRGPRTPQEEILCDLFMEVLHLPRVGIDDRFFDLGGHSLLA VQLMSRIREALGVELSIGNLFEAPTVAGLAERLEMGSSQSALDVLLPLRTSGDKPPLF CVHPAGGLSWCYAGLMTNIGTDYPIYGLQARGIGQREELPKTLDDMAADYIKQIRTVQ PKGPYHLLGWSLGGNVVQAMATQLQNQGEEVSLLVMLDAYPNHFLPIKEAPDDEEALI ALLALGGYDPDSLGEKPLDFEAAIEILRRDGSALASLDETVILNLKNTYVNSVGILGS YKPKTFRGNVLFFRSTIIPEWFDPIEPDSWKPYINGQIEQIDIDCRHKDLCQPEPLAQ IGKVLAVKLEELNK*" /label="dhbF CDS" gene complement(2798763..2805899) /gene="dhbF" /locus_tag="BSU_31960" /old_locus_tag="BSU31960" /label="dhbF gene" CDS complement(2805919..2806857) /gene="dhbB" /locus_tag="BSU_31970" /old_locus_tag="BSU31970" /EC_number="3.3.2.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8921902, 9214294, 11112781, 11790741, 12354229, 16672620, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isochorismatase (siderophore specific)" /protein_id="NP_391077.1" /db_xref="EnsemblGenomes-Gn:BSU31970" /db_xref="EnsemblGenomes-Tr:CAB15187" /db_xref="GOA:P45743" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR016291" /db_xref="InterPro:IPR036380" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11241" /db_xref="UniProtKB/Swiss-Prot:P45743" /translation="MAIPAIQPYQMPTASDMPQNKVSWVPDPNRAVLLIHDMQNYFVD AFTAGASPVTELSANIRKLKNQCVQLGIPVVYTAQPGSQNPDDRALLTDFWGPGLNSG PYEEKIITELAPEDDDLVLTKWRYSAFKRTNLLEMMRKEGRDQLIITGIYAHIGCLVT ACEAFMEDIKAFFVGDAVADFSLEKHQMALEYAAGRCAFTVMTDSLLDQLQNAPADVQ KTSANTGKKNVFTCENIRKQIAELLQETPEDITDQEDLLDRGLDSVRIMTLVEQWRRE GAEVTFVELAERPTIEEWQKLLTTRSQQVLPNADYL*" /label="dhbB CDS" gene complement(2805919..2806857) /gene="dhbB" /locus_tag="BSU_31970" /old_locus_tag="BSU31970" /label="dhbB gene" CDS complement(2806885..2808504) /gene="dhbE" /locus_tag="BSU_31980" /old_locus_tag="BSU31980" /EC_number="2.7.7.58" /EC_number="6.3.2.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8921902, 9214294, 11112781, 11790741, 12354229, 12221282, 16672620, 16403027, 23352143, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8921902, 9214294, 11112781, 11790741, 12354229, 12221282, 16672620, 16403027, 23352143, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,3-dihydroxybenzoate-AMP ligase" /protein_id="NP_391078.1" /db_xref="EnsemblGenomes-Gn:BSU31980" /db_xref="EnsemblGenomes-Tr:CAB15188" /db_xref="GOA:P40871" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR011963" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:1MD9" /db_xref="PDB:1MDB" /db_xref="PDB:1MDF" /db_xref="SubtiList:BG11020" /db_xref="UniProtKB/Swiss-Prot:P40871" /translation="MLKGFTPWPDELAETYRKNGCWAGETFGDLLRDRAAKYGDRIAI TCGNTHWSYRELDTRADRLAAGFQKLGIQQMDRVVVQLPNIKEFFEVIFALFRLGALP VFALPSHRSSEITYFCEFAEAAAYIIPDAYSGFDYRSLARQVQSKLPTLKNIIVAGEA EEFLPLEDLHAEPVKLPEVKSSDVAFLQLSGGSTGLSKLIPRTHDDYIYSLKRSVEVC WLDHSTVYLAALPMAHNYPLSSPGVLGVLYAGGRVVLSPSPSPDDAFPLIEREKVTIT ALVPPLAMVWMDAASSRRDDLSSLQVLQVGGAKFSAEAARRVKAVFGCTLQQVFGMAE GLVNYTRLDDPEEIIVNTQGKPMSPYDEMRVWDDHDRDVKPGETGHLLTRGPYTIRGY YKAEEHNAASFTEDGFYRTGDIVRLTRDGYIVVEGRAKDQINRGGEKVAAEEVENHLL AHPAVHDAAMVSMPDQFLGERSCVFIIPRDEAPKAAELKAFLRERGLAAYKIPDRVEF VESFPQTGVGKVSKKALREAISEKLLAGFKK*" /label="dhbE CDS" gene complement(2806885..2808504) /gene="dhbE" /locus_tag="BSU_31980" /old_locus_tag="BSU31980" /label="dhbE gene" CDS complement(2808533..2809729) /gene="dhbC" /locus_tag="BSU_31990" /old_locus_tag="BSU31990" /EC_number="5.4.4.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 12354229, 16672620, 19777807, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isochorismate synthase (siderophore-specific)" /protein_id="NP_391079.2" /db_xref="EnsemblGenomes-Gn:BSU31990" /db_xref="EnsemblGenomes-Tr:CAB15189" /db_xref="GOA:P45744" /db_xref="InterPro:IPR004561" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR015890" /db_xref="SubtiList:BG11242" /db_xref="UniProtKB/Swiss-Prot:P45744" /translation="MLDQNVITETKAEHLLHEYQPGAFFLASPHRVLLAKGICEIVPE ADGQNQMETLSGRIAEALRQAKQSGQSRPLVVGAVPFDQVKAARLVVPEEVRWSGPLQ FDHEEKEQQAGHTYHIKPVPEPEDYKNGVEQGLARIADGTLSKIVLSRSLHLTSPEPI QTDELLRHLAQHNSHGYTFAADVSSQEETSPRRTLLGASPELLVSRMGTQVVSNPLAG SRPRSNDPVEDQRRAAELLSSAKDLHEHAVVADAVAAALRPFCRTLEVPEKPSLIKTE TMWHLSSVIKGELSDPSVTALELAAALHPTPAVCGTPTDLAREAILSIEPFDRGFFTG MVGWCDDAGDGEWIVTIRCAEAEERSLRLYAGAGVVAGSKPEDELQETSAKFRTMLRA MGVDHI*" /label="dhbC CDS" gene complement(2808533..2809729) /gene="dhbC" /locus_tag="BSU_31990" /old_locus_tag="BSU31990" /label="dhbC gene" promotor_-35 2809577..2809584 /Source="Nicolas_upshift_promotors" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2809599..2809618 /Source="Nicolas_upshift_promotors" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2809606 /Source="Nicolas_upshifts" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2809755..2810540) /gene="dhbA" /locus_tag="BSU_32000" /old_locus_tag="BSU32000" /EC_number="1.3.1.28" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12354229, 16672620, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16672620, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase" /protein_id="NP_391080.2" /db_xref="EnsemblGenomes-Gn:BSU32000" /db_xref="EnsemblGenomes-Tr:CAB15190" /db_xref="GOA:P39071" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR003560" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11019" /db_xref="UniProtKB/Swiss-Prot:P39071" /translation="MNAKGIEGKIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEK LEKVVSSLKAEGRHAEAFPADVRDSAAIDEITARIEREMGPIDILVNVAGVLRPGLIH SLSDEEWEATFSVNSTGVFNASRSVSKYMMDRRSGSIVTVGSNAAGVPRTSMAAYASS KAAAVMFTKCLGLELAEYNIRCNIVSPGSTETDMQWSLWADENGAEQVIKGSLETFKT GIPLKKLAKPSDIADAVLFLVSGQAGHITMHNLCVDGGATLGV*" /label="dhbA CDS" gene complement(2809755..2810540) /gene="dhbA" /locus_tag="BSU_32000" /old_locus_tag="BSU32000" /label="dhbA gene" S_feature complement(2810541..2810650) /Source="Nicolas_S_feature" /locus_tag="new_3292297_3292406_c" /HighExp="HiOs, GM 15, B60, nit, GM 10, GM 25, B36, GM 60, dia0, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1228" promotor_-10 complement(2810645..2810664) /Source="Nicolas_upshift_promotors" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2810650) /Source="Nicolas_upshifts" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2810652..2810733) /Source="Nicolas_S_feature" /locus_tag="new_3292408_3292489_c" /HighExp="HiOs, B60, nit, B36, GM 45, GM 10, BI, GM 15, GM 25, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1229" promotor_-35 complement(2810678..2810685) /Source="Nicolas_upshift_promotors" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2810734..2811603) /gene="besA" /locus_tag="BSU_32010" /old_locus_tag="BSU32010" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16889643, 19673474, 26284661, 28283524; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillibactin trilactone hydrolase" /protein_id="NP_391081.2" /db_xref="EnsemblGenomes-Gn:BSU32010" /db_xref="EnsemblGenomes-Tr:CAB15191" /db_xref="GOA:O32102" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13974" /db_xref="UniProtKB/Swiss-Prot:O32102" /translation="MKEQTTDRTNGGTSNAFTIPGTEVRMMSSRNENRTYHIFISKPS TPPPPAGYPVIYLLDANSVFGTMTEAVRIQGRRPEKTGVIPAVIVGIGYETAEPFSSA RHRDFTMPTAQSKLPERPDGREWPEHGGAEGFFRFIEEDLKPEIERDYQIDKKRQTIF GHSLGGLFVLQVLLTKPDAFQTYIAGSPSIHWNKPFILKKTDHFVSLTKKNNQPINIL LAAGELEQHHKSRMNDNARELYERLAVLSEQGIRAEFCEFSGEGHISVLPVLVSRALR FALHPDGPHLSMG*" /label="besA CDS" gene complement(2810734..2811603) /gene="besA" /locus_tag="BSU_32010" /old_locus_tag="BSU32010" /label="besA gene" S_feature complement(2811604..2811684) /Source="Nicolas_S_feature" /locus_tag="new_3293360_3293440_c" /HighExp="HiOs, B60, nit, GM 15, BI, B36, LoTm, T-5.40H, Lbexp, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1230" promotor_-10 complement(2811668..2811687) /Source="Nicolas_upshift_promotors" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2811684) /Source="Nicolas_upshifts" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2811701..2811708) /Source="Nicolas_upshift_promotors" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2811817..2812413) /gene="yuiH" /locus_tag="BSU_32020" /old_locus_tag="BSU32020" /EC_number="1.7.3.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11598126, 16341843, 21190336; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdopterin containing enzyme subunit" /protein_id="NP_391082.1" /db_xref="EnsemblGenomes-Gn:BSU32020" /db_xref="EnsemblGenomes-Tr:CAB15192" /db_xref="GOA:O32103" /db_xref="InterPro:IPR000572" /db_xref="InterPro:IPR036374" /db_xref="SubtiList:BG13973" /db_xref="UniProtKB/Swiss-Prot:O32103" /translation="MYFGKTRQSDQSGRVPPNQNVTTSFPVLHTGDVPYYEDMTKWNL QVYGLVDHPMLLSFEDVKAFPRYESKNDIHCVTGWSRLDNVWQGVRACDIAEKAGVKE EAGYVILHAEEGWTTNLPLDDFLAETSLLAYAHNGEPLTPEHGFPLRGVFPHLYFWKS AKWLRGIQFTKENHPGFWERNGYHMRGDPWQNQRFTWD*" /label="yuiH CDS" gene complement(2811817..2812413) /gene="yuiH" /locus_tag="BSU_32020" /old_locus_tag="BSU32020" /label="yuiH gene" S_feature complement(2812414..2812498) /Source="Nicolas_S_feature" /locus_tag="new_3294170_3294254_c" /HighExp="H2O2, Paraq, Cold, dia15, G135, B36, G180, B60, LoTm, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.204" /TUlongSig="NA" /TUlongPSig="NA" /label="S1231" promotor_-35 2812449..2812456 /Source="Nicolas_upshift_promotors" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2812466 /Source="Nicolas_upshifts" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2812471..2812490 /Source="Nicolas_upshift_promotors" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2812492..2812506) /Source="Nicolas_upshift_promotors" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2812498) /Source="Nicolas_upshifts" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2812514..2812518) /Source="Nicolas_upshift_promotors" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2812514..2813116 /gene="bioYB" /locus_tag="BSU_32030" /old_locus_tag="BSU32030" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717296, 15849754, 16850406, 24816803; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative biotin transporter" /protein_id="NP_391083.1" /db_xref="EnsemblGenomes-Gn:BSU32030" /db_xref="EnsemblGenomes-Tr:CAB15193" /db_xref="GOA:O32104" /db_xref="InterPro:IPR003784" /db_xref="SubtiList:BG13972" /db_xref="UniProtKB/Swiss-Prot:O32104" /translation="MKQRKLRAGDMALIGMFAALMAVGANITSVAPFLQVAGIPLSMQ PFFCLLAALLLGSKRAAIAMIVYALVGLAGAPVFAQFSAGFAPFAGKSGGFIISYIPA AFAAGWFLERNIQPSKIRFLIASLIGTAIMYLIGTTYMYLALKLWIHTPVSYGTAWGF MIWFMVKDTALAVILSFIAPAIYRSIHKATGFNRNHISST*" /label="bioYB CDS" gene 2812514..2813116 /gene="bioYB" /locus_tag="BSU_32030" /old_locus_tag="BSU32030" /label="bioYB gene" downshifts 2813102 /Source="Nicolas_upshifts" /id="D1654" /incds=0 /nref=145 /ntot=206 /MaxReadThrough="3.24182" /MaxDrop="6.72885" /score="12.6395055" /energy="-6.3" /TU="U2498" /idTUdmin="U2498" /TUdmin="-24" /isTUend="FALSE" /label="downshifts" CDS complement(2813186..2814514) /gene="hisP" /locus_tag="BSU_32040" /old_locus_tag="BSU32040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15135544, 15849754, 16850406, 23504016; Product type t : transporter" /codon_start=1 /transl_table=11 /product="histidine / basic amino acid transporter" /protein_id="NP_391084.1" /db_xref="EnsemblGenomes-Gn:BSU32040" /db_xref="EnsemblGenomes-Tr:CAB15194" /db_xref="GOA:O32105" /db_xref="InterPro:IPR018461" /db_xref="InterPro:IPR032813" /db_xref="SubtiList:BG13971" /db_xref="UniProtKB/Swiss-Prot:O32105" /translation="MNAVVIAVLLMLVLSLLRVNIVIALIIGALAGGLTGGLGLGETV KAFTDGLGGNATVAVSYAMLGAFAAALTKTGLPDAMVEASVKLIGNKEDSRKKALSKV LIVLIILIVSCFSQNVVPVHIAFIPVLIPPLLKIFNELEMDRRLIACVITFGLTAPYI LLPVGFGQIFQGMLKDNMADAGLNVPLADIPYALIIPVAGMVVGLILSVIVYRKPKQY ETKDISGAEASPYTRKSIGIAVLAIVVSLGVQLYLSQTLGVEGMIMGALAGLIVLFVS GVMKRDEADSLITDGMVLMAFIGFVMLVAAGFSNVLTKTGDVESLVKTSAGFIGHSQS LGALLMLIVGLLITMGIGSSFATIPVITTIFVPLCMQLGFSPMATIAIIGAAAALGDA GSPASDSTLGPTSGLSADGQHHHIWDTCVPTFIFYNIPLVIFGWIAALVL*" /label="hisP CDS" gene complement(2813186..2814514) /gene="hisP" /locus_tag="BSU_32040" /old_locus_tag="BSU32040" /label="hisP gene" downshifts complement(2813202) /Source="Nicolas_upshifts" /id="D1655" /incds=0 /nref=14 /ntot=114 /MaxReadThrough="4.26298" /MaxDrop="4.37949" /score="18.6861113" /energy="-15.4" /TU="U2500" /idTUdmin="U2500" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2814568..2814587) /Source="Nicolas_upshift_promotors" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2814571) /Source="Nicolas_upshifts" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2814602..2814609) /Source="Nicolas_upshift_promotors" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2814661..2816163) /gene="pepA" /locus_tag="BSU_32050" /old_locus_tag="BSU32050" /EC_number="3.4.11.1" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8057849, 9864319, 10449417, 26936797; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytosol aminopeptidase" /protein_id="NP_391085.1" /db_xref="EnsemblGenomes-Gn:BSU32050" /db_xref="EnsemblGenomes-Tr:CAB15195" /db_xref="GOA:O32106" /db_xref="InterPro:IPR000819" /db_xref="InterPro:IPR008283" /db_xref="InterPro:IPR011356" /db_xref="InterPro:IPR023042" /db_xref="SubtiList:BG13970" /db_xref="UniProtKB/Swiss-Prot:O32106" /translation="MFYAVQQSEHTETLVVGLFQKSQLTGKALEIDEMLEGHLTQLLK EGDVSAKPNQVSKVFPPSSAGMKRIYFVGLGREANYSFEQAKERFAHVFQAIHKDRKQ ETAVLLDTFISEDVPPADAAHALAESCLLASYEVQDYKHKSNEPDKQIEAVYVVTDED TQEVQAGLRVGQAYGQGTNSARTLVNMPGNMLTATDLASYAEELAAKYDFECEILEKS EMEELGMGGILAVNQGSTEPPKMIVLKYQGKKEWEDVVGLVGKGITFDTGGYSIKTKS GIVGMKSDMGGAAAVLGAMETIGELRPEQNVLCVIPSTDNMISGGAMKPDDVIVSLSG KTIEILNTDAEGRLVLADGITYAKQHGASVLVDVATLTGGVVVALGTETTGAMTNDQS FYQQVADAAQECGEAIWQLPITEKDKKRVKSSQMADLSNSPGREGHAIMAGTFLGEFA ESTPWVHLDIAGTATANKATCFGPAGATGVMARTLATLAERFTLEEDKNE*" /label="pepA CDS" gene complement(2814661..2816163) /gene="pepA" /locus_tag="BSU_32050" /old_locus_tag="BSU32050" /label="pepA gene" downshifts complement(2814676) /Source="Nicolas_upshifts" /id="D1656" /incds=0 /nref=149 /ntot=220 /MaxReadThrough="4.44151" /MaxDrop="5.59726" /score="31.6277104" /energy="-16" /TU="NA" /idTUdmin="U2503" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 2815728..2815742 /Source="Nicolas_upshift_promotors" /id="U2501" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.345654345654346" /psig="0.420579420579421" /xcortree=308 /SigmaFactorBS="atcttcatctgttacaacatacacggcttcaatttgtttgtc agGCTCATTTGATTTATgcttataatcctgcacctcataggaagcaagcaggcagctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2815744 /Source="Nicolas_upshifts" /id="U2501" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.345654345654346" /psig="0.420579420579421" /xcortree=308 /SigmaFactorBS="atcttcatctgttacaacatacacggcttcaatttgtttgtc agGCTCATTTGATTTATgcttataatcctgcacctcataggaagcaagcaggcagctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2816164..2816238) /Source="Nicolas_S_feature" /locus_tag="new_3297920_3297994_c" /HighExp="M40t90, Lbtran, LBGtran, Lbstat, C90, M0t90, T1.0H, LoTm, M40t45, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1232" promotor_-35 2816186..2816193 /Source="Nicolas_upshift_promotors" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2816204..2816223 /Source="Nicolas_upshift_promotors" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2816206..2816320 /Source="Nicolas_S_feature" /locus_tag="new_3297962_3298076" /HighExp="Etha, Cold, Gly, Sw, LoTm, BC, B60, C90, dia5, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1233" upshifts 2816206 /Source="Nicolas_upshifts" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2816233..2816252) /Source="Nicolas_upshift_promotors" /id="U2503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.601398601398601" /psig="0.999000999001" /xcortree=3139 /SigmaFactorBS="tttgaaaaatccttcgtgtttcaaaagaaaaaagcaagtctt agactgttgTTTGTTAAAATAAGTATAGTggaaagaatgtttttcctattataccatt g" /listShort="S1232, pepA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2816243) /Source="Nicolas_upshifts" /id="U2503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.601398601398601" /psig="0.999000999001" /xcortree=3139 /SigmaFactorBS="tttgaaaaatccttcgtgtttcaaaagaaaaaagcaagtctt agactgttgTTTGTTAAAATAAGTATAGTggaaagaatgtttttcctattataccatt g" /listShort="S1232, pepA" /GFF_Attribute="listLong" /label="upshifts" CDS 2816321..2816797 /gene="yuiD" /locus_tag="BSU_32060" /old_locus_tag="BSU32060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391086.1" /db_xref="EnsemblGenomes-Gn:BSU32060" /db_xref="EnsemblGenomes-Tr:CAB15196" /db_xref="GOA:O32107" /db_xref="InterPro:IPR003832" /db_xref="SubtiList:BG13969" /db_xref="UniProtKB/Swiss-Prot:O32107" /translation="MELLTNFPLLSSLAAIIFAQVIKVPIQFIVSRKLDWSLVTSTGG MPSSHSAAVTALSTGVALEHGLDSSLFAVSAIFAVITMFDATGVRRHAGEQATVINKL VIDFNRFVNEAKDFPKAAEKEKQKKLKELLGHQPIEVFFGGLTGILLTLVLAYFFM*" /label="yuiD CDS" gene 2816321..2816797 /gene="yuiD" /locus_tag="BSU_32060" /old_locus_tag="BSU32060" /label="yuiD gene" downshifts 2816746 /Source="Nicolas_upshifts" /id="D1657" /incds=0 /nref=18 /ntot=174 /MaxReadThrough="3.22946" /MaxDrop="3.90704" /score="10.9647804" /energy="-11.6" /TU="U2502" /idTUdmin="U2502" /TUdmin="-208" /isTUend="FALSE" /label="downshifts" CDS complement(2816828..2817484) /gene="spsC" /locus_tag="BSU_32070" /old_locus_tag="BSU32070" /experiment="publication(s) with functional evidences, PMID:26163297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26163297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="stationary phase survival protein" /protein_id="NP_391087.1" /db_xref="EnsemblGenomes-Gn:BSU32070" /db_xref="EnsemblGenomes-Tr:CAB15197" /db_xref="GOA:O32108" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR036908" /db_xref="PDB:4WJT" /db_xref="PDB:4WLI" /db_xref="PDB:4WLK" /db_xref="SubtiList:BG13968" /db_xref="UniProtKB/Swiss-Prot:O32108" /translation="MMLNMIRRLLMTCLFLLAFGTTFLSVSGIEAKDLSKWVQEHQEK HLKHAGLRLKALQQKQTQTTSAAEDKTKPLEEAFDWDEYPVQRVTATGYTAGAESTGK NPGDPLYGLTYSGVKVKRDLYSTVAADPSVFPIGTILFIPNYGLGVVADTGSAIKGNR LDLYFETVKDVYNEWGKKTLDVYVIKKGTGKITEDELEKLNETKSLQVFRNQYKTVKE *" /label="spsC CDS" gene complement(2816828..2817484) /gene="spsC" /locus_tag="BSU_32070" /old_locus_tag="BSU32070" /label="spsC gene" downshifts complement(2816856) /Source="Nicolas_upshifts" /id="D1658" /incds=0 /nref=178 /ntot=253 /MaxReadThrough="0.714039999999999" /MaxDrop="6.31907" /score="33.0538307" /energy="-12.6" /TU="NA" /idTUdmin="U2505" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 2817132..2817141 /Source="Nicolas_upshift_promotors" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2817155..2817174 /Source="Nicolas_upshift_promotors" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2817172 /Source="Nicolas_upshifts" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="upshifts" S_feature 2817174..2817620 /Source="Nicolas_S_feature" /locus_tag="new_3298930_3299376" /HighExp="S6, S8, S7, BT, B36, G/S, S5, Pyr, Cold, B60" /AntisenseName="yuiC" /AntisenseCor="0.52395204592174105" /AntisenseRegPval="-19.600000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1234" upshifts complement(2817498) /Source="Nicolas_upshifts" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2817500..2817511) /Source="Nicolas_upshift_promotors" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2817526..2817532) /Source="Nicolas_upshift_promotors" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2817577 /Source="Nicolas_upshifts" /id="D1659" /incds=0 /nref=3 /ntot=11 /MaxReadThrough="7.61734" /MaxDrop="4.9382" /score="4.8726481" /energy="-7.9" /TU="U2504" /idTUdmin="U2506" /TUdmin="-323" /isTUend="FALSE" /label="downshifts" CDS complement(2817588..2817908) /gene="yuiB" /locus_tag="BSU_32080" /old_locus_tag="BSU32080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391088.1" /db_xref="EnsemblGenomes-Gn:BSU32080" /db_xref="EnsemblGenomes-Tr:CAB15198" /db_xref="GOA:O32109" /db_xref="InterPro:IPR025917" /db_xref="SubtiList:BG13967" /db_xref="UniProtKB/Swiss-Prot:O32109" /translation="MISLPVVIISIVLFFVLFFGIGFLLNMLLRMSWIMAVIYPIVCL FIISKEKLISYVQSPGESFASLFHRVLSLAAADVLILVSGLAGAIVSGIAINMLRKRG YQMF*" /label="yuiB CDS" gene complement(2817588..2817908) /gene="yuiB" /locus_tag="BSU_32080" /old_locus_tag="BSU32080" /label="yuiB gene" downshifts complement(2817602) /Source="Nicolas_upshifts" /id="D1660" /incds=0 /nref=151 /ntot=218 /MaxReadThrough="4.24535" /MaxDrop="5.6597" /score="13.4559443" /energy="-7.6" /TU="U2507,U2508" /idTUdmin="U2510" /TUdmin=660 /isTUend="FALSE" /label="downshifts" S_feature 2817622..2817832 /Source="Nicolas_S_feature" /locus_tag="new_3299378_3299588" /HighExp="S8, S6, S7, BT, Cold, Gly, H2O2, G/S, C30, G180" /AntisenseName="yuiB" /AntisenseCor="-0.11290507783715401" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1235" promotor_no_box 2817774..2817874 /Source="Nicolas_upshift_promotors" /id="U2506" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.641358641358641" /psig="0.02997002997003" /xcortree=280 /SigmaFactorBS="gaaaaggcatacaattggataaatcacagccataatccaaga cattctcagcagcatgtttaataagaaaccgattccaaaaaacaagacaaaaaacaaa a" /listShort="S1236" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 2817834..2817943 /Source="Nicolas_S_feature" /locus_tag="new_3299590_3299699" /HighExp="S8, S6, BT, S7, Sw, Gly, G180, BC, Diami, H2O2" /AntisenseName="yuiB" /AntisenseCor="-7.7565560595235006E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.03, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1236" upshifts 2817834 /Source="Nicolas_upshifts" /id="U2506" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.641358641358641" /psig="0.02997002997003" /xcortree=280 /SigmaFactorBS="gaaaaggcatacaattggataaatcacagccataatccaaga cattctcagcagcatgtttaataagaaaccgattccaaaaaacaagacaaaaaacaaa a" /listShort="S1236" /GFF_Attribute="listLong" /label="upshifts" downshifts 2817900 /Source="Nicolas_upshifts" /id="D1661" /incds=0 /nref=10 /ntot=28 /MaxReadThrough="3.79664" /MaxDrop="6.06021" /score="4.8726481" /energy="-7.9" /TU="U2504" /idTUdmin="U2506" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2817927..2817946) /Source="Nicolas_upshift_promotors" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2817932) /Source="Nicolas_upshifts" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="upshifts" S_feature 2817945..2818496 /Source="Nicolas_S_feature" /locus_tag="new_3299701_3300252" /HighExp="S6, S8, S7, Cold, H2O2, BC, Sw, Pyr, BT, C30" /AntisenseName="yuiA" /AntisenseCor="5.87811391089679E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1237" promotor_-35 complement(2817961..2817968) /Source="Nicolas_upshift_promotors" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2817962..2818105) /gene="yuiA" /locus_tag="BSU_32090" /old_locus_tag="BSU32090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391089.1" /db_xref="EnsemblGenomes-Gn:BSU32090" /db_xref="EnsemblGenomes-Tr:CAB15199" /db_xref="InterPro:IPR035272" /db_xref="InterPro:IPR036410" /db_xref="SubtiList:BG12389" /db_xref="UniProtKB/Swiss-Prot:O32110" /translation="MKTATTTASHACPFCSGKGYFQLILGGSETCPSCQGTGKDSHSF SSR*" /label="yuiA CDS" gene complement(2817962..2818105) /gene="yuiA" /locus_tag="BSU_32090" /old_locus_tag="BSU32090" /label="yuiA gene" promotor_-10 complement(2818129..2818148) /Source="Nicolas_upshift_promotors" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2818150) /Source="Nicolas_upshifts" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2818164..2818167) /Source="Nicolas_upshift_promotors" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2818278..2819498) /gene="yumB" /locus_tag="BSU_32100" /old_locus_tag="BSU32100" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154, 17015645, 26098117; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-disulfide oxidoreductase" /protein_id="NP_391090.1" /db_xref="EnsemblGenomes-Gn:BSU32100" /db_xref="EnsemblGenomes-Tr:CAB15200" /db_xref="GOA:O05267" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12390" /db_xref="UniProtKB/Swiss-Prot:O05267" /translation="MALNKPKIVILGAGYGGLMTVTRLTKYVGPNDADITLVNKHNYH YETTWMHEASAGTLHHDRCRYQIKDVINQSRVNFVQDTVKAIKIDEKKVVLANGELQY DYLVIGLGAVPETFGIKGLKEYAFPIANINTSRLLREHIELQFATYNTEAEKRPDRLT IVVGGAGFTGIEFLGELAARVPELCKEYDVDRSLVRIICVEAAPTVLPGFDPELVDYA VHYLEENGVEFKIGTAVQECTPEGVRVGKKDEEPEQIKSQTVVWAAGVRGHPIVEEAG FENMRGRVKVNPDLRAPGHDNVFILGDSSLFMNEDTERPYPPTAQIAMQQGITVAKNL GRLIKGGELEEFKPDIKGTVASLGEHNAVGVVYGRKLKGTPASFMKKVIDNRSLFMIG GLGLTLKKGKFKFF*" /label="yumB CDS" gene complement(2818278..2819498) /gene="yumB" /locus_tag="BSU_32100" /old_locus_tag="BSU32100" /label="yumB gene" downshifts complement(2818306) /Source="Nicolas_upshifts" /id="D1662" /incds=0 /nref=15 /ntot=123 /MaxReadThrough="3.19525" /MaxDrop="3.6794" /score="23.523765" /energy="-8.9" /TU="U2510" /idTUdmin="U2509" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2819499..2819626) /Source="Nicolas_S_feature" /locus_tag="new_3301255_3301382_c" /HighExp="Salt, S4, Etha, S5, S3, S7, S6, LoTm, B36, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.752, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1238" upshifts complement(2819626) /Source="Nicolas_upshifts" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2819628..2819692) /Source="Nicolas_S_feature" /locus_tag="new_3301384_3301448_c" /HighExp="Salt, Etha, Heat, BMM, BC, H2O2, Paraq, C30, Sw, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1239" promotor_-10 complement(2819628..2819646) /Source="Nicolas_upshift_promotors" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2819662..2819667) /Source="Nicolas_upshift_promotors" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2819683..2819702) /Source="Nicolas_upshift_promotors" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2819691) /Source="Nicolas_upshifts" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2819717..2819724) /Source="Nicolas_upshift_promotors" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2819766..2819773 /Source="Nicolas_upshift_promotors" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2819785..2819804 /Source="Nicolas_upshift_promotors" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2819785 /Source="Nicolas_upshifts" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="upshifts" CDS 2819830..2820828 /gene="trxBB" /locus_tag="BSU_32110" /old_locus_tag="BSU32110" /EC_number="1.18.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:15252706, 22938038, 26507228, 26965753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15252706, 22938038, 26507228, 26965753; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ferredoxin-NADP+ reductase (flavodoxin)" /protein_id="NP_391091.2" /db_xref="EnsemblGenomes-Gn:BSU32110" /db_xref="EnsemblGenomes-Tr:CAB15201" /db_xref="GOA:O05268" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR022890" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="PDB:3LZW" /db_xref="PDB:3LZX" /db_xref="SubtiList:BG12391" /db_xref="UniProtKB/Swiss-Prot:O05268" /translation="MREDTKVYDITIIGGGPVGLFTAFYGGMRQASVKIIESLPQLGG QLSALYPEKYIYDVAGFPKIRAQELINNLKEQMAKFDQTICLEQAVESVEKQADGVFK LVTNEETHYSKTVIITAGNGAFKPRKLELENAEQYEGKNLHYFVDDLQKFAGRRVAIL GGGDSAVDWALMLEPIAKEVSIIHRRDKFRAHEHSVENLHASKVNVLTPFVPAELIGE DKIEQLVLEEVKGDRKEILEIDDLIVNYGFVSSLGPIKNWGLDIEKNSIVVKSTMETN IEGFFAAGDICTYEGKVNLIASGFGEAPTAVNNAKAYMDPKARVQPLHSTSLFENK*" /label="trxBB CDS" gene 2819830..2820828 /gene="trxBB" /locus_tag="BSU_32110" /old_locus_tag="BSU32110" /label="trxBB gene" promotor_-10 complement(2819853..2819871) /Source="Nicolas_upshift_promotors" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2819868) /Source="Nicolas_upshifts" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2819888..2819893) /Source="Nicolas_upshift_promotors" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2820804 /Source="Nicolas_upshifts" /id="D1663" /incds=0 /nref=162 /ntot=262 /MaxReadThrough="0.70088" /MaxDrop="7.47867" /score="21.6819221" /energy="-12.8" /TU="U2511" /idTUdmin="U2511" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2820867..2821007) /gene="yuzG" /locus_tag="BSU_32120" /old_locus_tag="BSU32120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein or unknown function" /protein_id="NP_391092.1" /db_xref="EnsemblGenomes-Gn:BSU32120" /db_xref="EnsemblGenomes-Tr:CAB15202" /db_xref="GOA:O32111" /db_xref="SubtiList:BG14056" /db_xref="UniProtKB/Swiss-Prot:O32111" /translation="MAQNEEKTPKSQKIQDRIIMAMIWVVAALVIALVVGTALNYINI FK*" /label="yuzG CDS" gene complement(2820867..2821007) /gene="yuzG" /locus_tag="BSU_32120" /old_locus_tag="BSU32120" /label="yuzG gene" downshifts complement(2820879) /Source="Nicolas_upshifts" /id="D1664" /incds=0 /nref=61 /ntot=234 /MaxReadThrough="1.27572" /MaxDrop="5.65243" /score="32.0354025" /energy="-12.8" /TU="NA" /idTUdmin="U2515" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(2821008..2821137) /Source="Nicolas_S_feature" /locus_tag="new_3302764_3302893_c" /HighExp="dia15, Salt, Cold, Diami, H2O2, Etha, GM 15, dia5, MG-0.2, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.36371900000000001" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1240" promotor_-10 complement(2821118..2821137) /Source="Nicolas_upshift_promotors" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2821137) /Source="Nicolas_upshifts" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2821139..2821386) /Source="Nicolas_S_feature" /locus_tag="new_3302895_3303142_c" /HighExp="S8, S5, S6, S7, S4, ferm, nit, C30, Pyr, T5.0H" /AntisenseName="guaC" /AntisenseCor="-0.291283195124732" /AntisenseRegPval="-5.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1241" promotor_-35 complement(2821151..2821157) /Source="Nicolas_upshift_promotors" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2821194..2821201 /Source="Nicolas_upshift_promotors" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2821215..2821234 /Source="Nicolas_upshift_promotors" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2821223 /Source="Nicolas_upshifts" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="upshifts" CDS 2821286..2822266 /gene="guaC" /locus_tag="BSU_32130" /old_locus_tag="BSU32130" /EC_number="1.7.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 11591660, 6408059" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 11591660, 6408059; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GMP reductase (NADP-dependent)" /protein_id="NP_391093.2" /db_xref="EnsemblGenomes-Gn:BSU32130" /db_xref="EnsemblGenomes-Tr:CAB15203" /db_xref="GOA:O05269" /db_xref="InterPro:IPR001093" /db_xref="InterPro:IPR005994" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR015875" /db_xref="SubtiList:BG12392" /db_xref="UniProtKB/Swiss-Prot:O05269" /translation="MENVFDYEDIQLIPAKCIVNSRSECDTSVRLGGHTFKLPVVPAN MQTIIDEKLAISLAENGYFYVMHRFEPETRIDFIKDMNARGLFSSISVGVKDEEYEFV RQLAEENLTPEYVTIDIAHGHSNAVIEMIQHLKKHLPDSFVIAGNVGTPEAVRELENA GADATKVGIGPGKVCITKIKTGFGTGGWQLAALRWCAKAASKPIIADGGIRTHGDIAK SIRFGATMVMIGSLFAGHEESPGQTIEKDGKLYKEYFGSASEFQKGEKKNVEGKKMHV AHKGSIKDTLIEMEQDLQSSISYAGGTKLNAIRNVDYVIVKNSIFNGDKY*" /label="guaC CDS" gene 2821286..2822266 /gene="guaC" /locus_tag="BSU_32130" /old_locus_tag="BSU32130" /label="guaC gene" upshifts complement(2821387) /Source="Nicolas_upshifts" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2821391..2821402) /Source="Nicolas_upshift_promotors" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2821416..2821422) /Source="Nicolas_upshift_promotors" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2822234 /Source="Nicolas_upshifts" /id="D1665" /incds=0 /nref=91 /ntot=186 /MaxReadThrough="1.24882" /MaxDrop="7.43286" /score="-2.82053244" /energy="-16.2" /TU="NA" /idTUdmin="U2514" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2822339) /Source="Nicolas_upshifts" /id="D1666" /incds=0 /nref=24 /ntot=212 /MaxReadThrough="1.15696" /MaxDrop="6.12198" /score="23.834956" /energy="-16.2" /TU="NA" /idTUdmin="U2517" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2822340..2822963) /gene="paiB" /locus_tag="BSU_32140" /old_locus_tag="BSU32140" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16210326, 21633969; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transcriptional regulator (regulates paiA expression)" /protein_id="NP_391094.2" /db_xref="EnsemblGenomes-Gn:BSU32140" /db_xref="EnsemblGenomes-Tr:CAB15204" /db_xref="GOA:P21341" /db_xref="InterPro:IPR007396" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG10696" /db_xref="UniProtKB/Swiss-Prot:P21341" /translation="MYIPKYFKVTNAEEIWNFVQENSFGTVVTTEQGKPIATHLPLGF NKKDDHYYITGHFAYGNPQWRTFEACEDVLVMFQGPHAYISSSWYSRENVPTWNYQAV HMYGKASMLEKDELAEELTIMLEKYEKHRDNPVLWDKLSPKLLESELKGIVGFKIKVE DIQAAYKLSQNRNETDYMNVIEQLQNEENPNAKQMAELMEDKLKKQI*" /label="paiB CDS" gene complement(2822340..2822963) /gene="paiB" /locus_tag="BSU_32140" /old_locus_tag="BSU32140" /label="paiB gene" CDS complement(2822987..2823505) /gene="paiA" /locus_tag="BSU_32150" /old_locus_tag="BSU32150" /EC_number="2.3.1.57" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16210326, 17588214, 21633970, 26818562, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16210326, 17588214, 21633970, 26818562, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polyamine N-acetyltransferase" /protein_id="NP_391095.1" /db_xref="EnsemblGenomes-Gn:BSU32150" /db_xref="EnsemblGenomes-Tr:CAB15205" /db_xref="GOA:P21340" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1TIQ" /db_xref="SubtiList:BG10695" /db_xref="UniProtKB/Swiss-Prot:P21340" /translation="MSVKMKKCSREDLQTLQQLSIETFNDTFKEQNSPENMKAYLESA FNTEQLEKELSNMSSQFFFIYFDHEIAGYVKVNIDDAQSEEMGAESLEIERIYIKNSF QKHGLGKHLLNKAIEIALERNKKNIWLGVWEKNENAIAFYKKMGFVQTGAHSFYMGDE EQTDLIMAKTLI*" /label="paiA CDS" gene complement(2822987..2823505) /gene="paiA" /locus_tag="BSU_32150" /old_locus_tag="BSU32150" /label="paiA gene" misc_feature complement(2823552..2823571) /Source="Nicolas_upshift_promotors" /id="U2516" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.719280719280719" /psig="0.937062937062937" /xcortree=2765 /SigmaFactorBS="ggagttggtgatgaagaagatttttggaatggtaacaaggtc agtatgtgttcCGTGTTTAAATATATAAAAGggacacaagacaattgaattttaaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2823564) /Source="Nicolas_upshifts" /id="U2516" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.719280719280719" /psig="0.937062937062937" /xcortree=2765 /SigmaFactorBS="ggagttggtgatgaagaagatttttggaatggtaacaaggtc agtatgtgttcCGTGTTTAAATATATAAAAGggacacaagacaattgaattttaaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2823566..2823674) /Source="Nicolas_S_feature" /locus_tag="new_3305322_3305430_c" /HighExp="LoTm, HiTm, G135, Salt, G180, Cold, LBGstat, T0.0H, B36, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1242" promotor_-10 complement(2823661..2823678) /Source="Nicolas_upshift_promotors" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2823672) /Source="Nicolas_upshifts" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2823693..2823700) /Source="Nicolas_upshift_promotors" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2823828) /Source="Nicolas_upshifts" /id="D1667" /incds=0 /nref=267 /ntot=269 /MaxReadThrough="1.56881" /MaxDrop="8.24828" /score="12.6937405" /energy="-18.7" /TU="NA" /idTUdmin="U2518" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2823843..2824205) /gene="sufA" /locus_tag="BSU_32160" /old_locus_tag="BSU32160" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17698959, 19478995, 20097860, 25447545; Product type c: carrier" /codon_start=1 /transl_table=11 /product="sulfur carrier chaperone involved in Fe-S cluster assembly" /protein_id="NP_391096.1" /db_xref="EnsemblGenomes-Gn:BSU32160" /db_xref="EnsemblGenomes-Tr:CAB15206" /db_xref="GOA:O32113" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR016092" /db_xref="InterPro:IPR017870" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG14049" /db_xref="UniProtKB/Swiss-Prot:O32113" /translation="MSNPVTITEAAALHIKDMMKEHEEENAFLRVGVKGGGCSGLSYG MGFEHEKSESDSVFDQHGITVLVDKESLDIMNGTVIDYKQSMLGGGFTIDNPNAIASC GCGSSFRTATNAGKPEEC*" /label="sufA CDS" gene complement(2823843..2824205) /gene="sufA" /locus_tag="BSU_32160" /old_locus_tag="BSU32160" /label="sufA gene" promotor_-10 complement(2824236..2824255) /Source="Nicolas_upshift_promotors" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2824246) /Source="Nicolas_upshifts" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2824269..2824276) /Source="Nicolas_upshift_promotors" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2824284..2825138) /gene="dapF" /locus_tag="BSU_32170" /old_locus_tag="BSU32170" /EC_number="5.1.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 14627808, 16723397, 19307721, 28873470; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diaminopimelate epimerase" /protein_id="NP_391097.1" /db_xref="EnsemblGenomes-Gn:BSU32170" /db_xref="EnsemblGenomes-Tr:CAB15207" /db_xref="GOA:O32114" /db_xref="InterPro:IPR001653" /db_xref="InterPro:IPR018510" /db_xref="SubtiList:BG14048" /db_xref="UniProtKB/Swiss-Prot:O32114" /translation="MNSFRFTKMHGLGNSYIYVNQFEEQLPEEKLSEIAIQVSSVYTG IGSDGMILICPSDQAPVKMRIFNNDGSEGKNCGNGLRCVAKYAYEHKLVEETSFLIET LSGLVKAEVQVENGKVNVVTVDMGEPRLTKSELPMLDGGEEHTINETMAFGEVELTGT AVSMGNPHIVFPIADIEQAPLTTLGPVIEKDPRFPEGINVEFVETVNEQELHFRVWER GSGITQACGTGACAAAVASVLNGVSKRNQDITVHLAGGDLVINWKDNGHVMMTGPAET VCEGVYFL*" /label="dapF CDS" gene complement(2824284..2825138) /gene="dapF" /locus_tag="BSU_32170" /old_locus_tag="BSU32170" /label="dapF gene" promotor_-10 complement(2824854..2824873) /Source="Nicolas_upshift_promotors" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2824862) /Source="Nicolas_upshifts" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2824886..2824895) /Source="Nicolas_upshift_promotors" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2825160..2825179) /Source="Nicolas_upshift_promotors" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2825174) /Source="Nicolas_upshifts" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2825194..2825197) /Source="Nicolas_upshift_promotors" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2825261..2826475) /gene="yutK" /locus_tag="BSU_32180" /old_locus_tag="BSU32180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+(H+)/nucleoside cotransporter" /protein_id="NP_391098.1" /db_xref="EnsemblGenomes-Gn:BSU32180" /db_xref="EnsemblGenomes-Tr:CAB15208" /db_xref="GOA:O32115" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG14047" /db_xref="UniProtKB/Swiss-Prot:O32115" /translation="MNVLWGLLGAVAIIAIAFLFSEKKSNIKIRTVIVGLCTQVAFGY IVLKWEAGRAVFLWFSSRVQLLIDYANEGISFIFGPLLKVGDSPAFALSVLPVIIFFS ALIAVLYHLKIMQLVFRVIGGGLSKLLGTSKTESLAAAANIFVGQSESPLVIKPLIAG LTRSELFTIMTSGLSAVAGSTLFGYALLGIPIEYLLAASFMAAPAGLVFGKLIIPETE KTQTVKSDFKMDEGEGAANVIDAAAKGASTGLQIALNVGAMLLAFVALIAVVNGILGG AFGLFGLKGVTLESILGYVFSPIAFLIGVPWHEALQAGSYIGQKLVLNEFVAYSNFGS HIGEFSKKTATIISFALCGFANFSSIAIMLGTLGGLAPSRRSDIARLGLKAVLAGTLA NLLSAAIAGMFI*" /label="yutK CDS" gene complement(2825261..2826475) /gene="yutK" /locus_tag="BSU_32180" /old_locus_tag="BSU32180" /label="yutK gene" promotor_-35 2825810..2825816 /Source="Nicolas_upshift_promotors" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="promotor_-35" promotor_-10 2825831..2825849 /Source="Nicolas_upshift_promotors" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="promotor_-10" upshifts 2825838 /Source="Nicolas_upshifts" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="upshifts" S_feature 2825842..2826611 /Source="Nicolas_S_feature" /locus_tag="new_3307598_3308367" /HighExp="Etha, Salt, Gly, M9-stat, Sw, LoTm, B60, BC, Heat, S0" /AntisenseName="yutK" /AntisenseCor="-0.36240965013078302" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1243" promotor_-10 complement(2826512..2826531) /Source="Nicolas_upshift_promotors" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="promotor_-10" upshifts complement(2826517) /Source="Nicolas_upshifts" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="upshifts" promotor_-35 complement(2826546..2826553) /Source="Nicolas_upshift_promotors" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="promotor_-35" downshifts 2826568 /Source="Nicolas_upshifts" /id="D1668" /incds=0 /nref=3 /ntot=58 /MaxReadThrough="4.13852" /MaxDrop="3.94079" /score="20.5760616" /energy="-10.5" /TU="U2521" /idTUdmin="U2521" /TUdmin="-1913" /isTUend="FALSE" /label="downshifts" CDS complement(2826612..2826848) /gene="yuzB" /locus_tag="BSU_32190" /old_locus_tag="BSU32190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391099.1" /db_xref="EnsemblGenomes-Gn:BSU32190" /db_xref="EnsemblGenomes-Tr:CAB15209" /db_xref="InterPro:IPR009910" /db_xref="InterPro:IPR022916" /db_xref="SubtiList:BG14051" /db_xref="UniProtKB/Swiss-Prot:O32116" /translation="MNPMIEFCVSNLAHGSQEARAILEKDPNLDVLEYGCLSYCGTCM ESLFALVNGEVVMGETPAELVENIYTFIEENPMF*" /label="yuzB CDS" gene complement(2826612..2826848) /gene="yuzB" /locus_tag="BSU_32190" /old_locus_tag="BSU32190" /label="yuzB gene" S_feature 2826613..2827029 /Source="Nicolas_S_feature" /locus_tag="new_3308369_3308785" /HighExp="Salt, LoTm, Gly, Etha, Sw, Heat, S0, C30, M9-stat, Mal" /AntisenseName="yuzB" /AntisenseCor="-5.6824456709843603E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1244" downshifts complement(2826630) /Source="Nicolas_upshifts" /id="D1669" /incds=0 /nref=175 /ntot=239 /MaxReadThrough="1.28789" /MaxDrop="7.32368" /score="41.4640292" /energy="-10.5" /TU="NA" /idTUdmin="U2523" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2826813..2826814) /Source="Nicolas_upshift_promotors" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2826818..2826822) /Source="Nicolas_upshift_promotors" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2826820) /Source="Nicolas_upshifts" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2826863..2826882) /Source="Nicolas_upshift_promotors" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2826864) /Source="Nicolas_upshifts" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2826896..2826903) /Source="Nicolas_upshift_promotors" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2827006..2827011 /Source="Nicolas_upshift_promotors" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="promotor_-35" promotor_-10 2827025..2827044 /Source="Nicolas_upshift_promotors" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="promotor_-10" upshifts 2827031 /Source="Nicolas_upshifts" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="upshifts" CDS 2827111..2828178 /gene="yutJ" /locus_tag="BSU_32200" /old_locus_tag="BSU32200" /EC_number="1.6.-.-" /function="16.10: Respire" /function="16.7: Manage energy" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17015645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH dehydrogenase" /protein_id="NP_391100.2" /db_xref="EnsemblGenomes-Gn:BSU32200" /db_xref="EnsemblGenomes-Tr:CAB15210" /db_xref="GOA:O32117" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG14046" /db_xref="UniProtKB/Swiss-Prot:O32117" /translation="MKKLVLIGGGYGNMRVLHRLLPNQLPDDVSITLIDRNPYHCLKT EYYALAAGTISDHHIRVSFPEHPRLDVQYGDITSIDIVQKQVLFQDREPISYDDAIIG LGCEDKYHNVPGAPEFTYSIQTIDQSRETYQKLNNLSANATVAIVGAGLSGVELASEL RESRDDLNIILFDRGNLILSSFPERLSKYVQKWFEEHGVRIINRANITKVEEGVVYNH DDPISADAIVWTAGIQPNKVVRDLDVEKDAQGRIVLTPHHNLPGDEHLYVVGDCASLP HAPSAQLAEAQAEQIVQILQKRWNGEALPESMPQFKLKGVLGSLGKKAGFGLVADRPL IGRVPRMLKSGLLWMYKHHNG*" /label="yutJ CDS" gene 2827111..2828178 /gene="yutJ" /locus_tag="BSU_32200" /old_locus_tag="BSU32200" /label="yutJ gene" downshifts 2828162 /Source="Nicolas_upshifts" /id="D1670" /incds=0 /nref=4 /ntot=110 /MaxReadThrough="3.51945" /MaxDrop="3.02708" /score="6.15657679" /energy="-10.8" /TU="U2521,U2525" /idTUdmin="U2521" /TUdmin="-319" /isTUend="FALSE" /label="downshifts" CDS complement(2828204..2828530) /gene="yuzD" /locus_tag="BSU_32210" /old_locus_tag="BSU32210" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11551182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur oxido-reduction management enzyme" /protein_id="NP_391101.1" /db_xref="EnsemblGenomes-Gn:BSU32210" /db_xref="EnsemblGenomes-Tr:CAB15211" /db_xref="InterPro:IPR009190" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14053" /db_xref="UniProtKB/Swiss-Prot:O32118" /translation="MMKPVMLSVYGAENVCASCVNMPTAKDTYEWLEAALKRKYPNQP FEMQYIDIHEPPDNEHAKELAEKIRNDEYFYPLVLVEDKIVGEGNPKLKDVYEEMEKH GYTENR*" /label="yuzD CDS" gene complement(2828204..2828530) /gene="yuzD" /locus_tag="BSU_32210" /old_locus_tag="BSU32210" /label="yuzD gene" downshifts complement(2828227) /Source="Nicolas_upshifts" /id="D1671" /incds=0 /nref=4 /ntot=180 /MaxReadThrough="1.63835" /MaxDrop="3.17377" /score="-8.05690984" /energy="-10.8" /TU="NA" /idTUdmin="U2526" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2828562..2828581) /Source="Nicolas_upshift_promotors" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2828579) /Source="Nicolas_upshifts" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2828594..2828601) /Source="Nicolas_upshift_promotors" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2828614..2828618 /Source="Nicolas_upshift_promotors" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2828630..2828965 /gene="yutI" /locus_tag="BSU_32220" /old_locus_tag="BSU32220" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17237162, 21749987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative iron-sulfur scaffold protein" /protein_id="NP_391102.1" /db_xref="EnsemblGenomes-Gn:BSU32220" /db_xref="EnsemblGenomes-Tr:CAB15212" /db_xref="GOA:O32119" /db_xref="InterPro:IPR001075" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG14045" /db_xref="UniProtKB/Swiss-Prot:O32119" /translation="MCYNRESNFANQTIDFYCYTEYNGFMTTKGANVMTEVEMKEQVQ EVLDKLRPFLLRDGGDCELVDVDEGIVKLRLLGACGSCPSSTITLKAGIERALLEEVP GVVEVEQVF*" /label="yutI CDS" gene 2828630..2828965 /gene="yutI" /locus_tag="BSU_32220" /old_locus_tag="BSU32220" /label="yutI gene" promotor_-10 2828631..2828650 /Source="Nicolas_upshift_promotors" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2828636 /Source="Nicolas_upshifts" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2828755) /Source="Nicolas_upshifts" /id="D1672" /incds=1 /nref=1 /ntot=5 /MaxReadThrough="1.28655" /MaxDrop="3.45909" /score="7.3681553" /energy="-21.2" /TU="NA" /idTUdmin="U2528" /TUdmin=264 /isTUend="FALSE" /label="downshifts" downshifts 2828943 /Source="Nicolas_upshifts" /id="D1673" /incds=0 /nref=258 /ntot=281 /MaxReadThrough="3.6035" /MaxDrop="7.98922" /score="39.7008566" /energy="-19.5" /TU="U2527" /idTUdmin="U2527" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(2829007..2830980) /gene="yuxL" /locus_tag="BSU_32230" /old_locus_tag="BSU32230" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8576092, 11406580; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acylaminoacyl-peptidase" /protein_id="NP_391103.2" /db_xref="EnsemblGenomes-Gn:BSU32230" /db_xref="EnsemblGenomes-Tr:CAB15213" /db_xref="GOA:P39839" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR011659" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG10463" /db_xref="UniProtKB/Swiss-Prot:P39839" /translation="MKKLITADDITAIVSVTDPQYAPDGTRAAYVKSQVNQEKDSYTS NIWIYETKTGGSVPWTHGEKRSTDPRWSPDGRTLAFISDREGDAAQLYIMSTEGGEAR KLTDIPYGVSKPLWSPDGESILVTVSLGEGESIDDREKTEQDSYEPVEVQGLSYKRDG KGLTRGAYAQLVLVSVKSGEMKELTSHKADHGDPAFSPDGKWLVFSANLTETDDASKP HDVYIMSLESGDLKQVTPHRGSFGSSSFSPDGRYLALLGNEKEYKNATLSKAWLYDIE QGRLTCLTEMLDVHLADALIGDSLIGGAEQRPIWTKDSQGFYVIGTDQGSTGIYYISI EGLVYPIRLEKEYINSFSLSPDEQHFIASVTKPDRPSELYSIPLGQEEKQLTGANDKF VREHTISIPEEIQYATEDGVMVNGWLMRPAQMEGETTYPLILNIHGGPHMMYGHTYFH EFQVLAAKGYAVVYINPRGSHGYGQEFVNAVRGDYGGKDYDDVMQAVDEAIKRDPHID PKRLGVTGGSYGGFMTNWIVGQTNRFKAAVTQRSISNWISFHGVSDIGYFFTDWQLEH DMFEDTEKLWDRSPLKYAANVETPLLILHGERDDRCPIEQAEQLFIALKKMGKETKLV RFPNASHNLSRTGHPRQRIKRLNYISSWFDQHL*" /label="yuxL CDS" gene complement(2829007..2830980) /gene="yuxL" /locus_tag="BSU_32230" /old_locus_tag="BSU32230" /label="yuxL gene" downshifts complement(2829019) /Source="Nicolas_upshifts" /id="D1674" /incds=0 /nref=19 /ntot=114 /MaxReadThrough="1.79797" /MaxDrop="3.85507" /score="7.3681553" /energy="-21.2" /TU="NA" /idTUdmin="U2528" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2830995..2831013) /Source="Nicolas_upshift_promotors" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2831018) /Source="Nicolas_upshifts" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2831025..2831033) /Source="Nicolas_upshift_promotors" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2831088..2832017) /gene="thrB" /locus_tag="BSU_32240" /old_locus_tag="BSU32240" /EC_number="2.7.1.39" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3098560, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3098560, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homoserine kinase" /protein_id="NP_391104.1" /db_xref="EnsemblGenomes-Gn:BSU32240" /db_xref="EnsemblGenomes-Tr:CAB15214" /db_xref="GOA:P04948" /db_xref="InterPro:IPR000870" /db_xref="InterPro:IPR006203" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10462" /db_xref="UniProtKB/Swiss-Prot:P04948" /translation="MNEADMLFSVTVPGSTANLGPGFDSVGMALSRYLKLTVFESDKW SFEAETETVAGIPAGTDNLIYQVAKRTADLYGKEMPPVHVKVWSDIPLARGLGSSAAA IVAAIELADELCGLKLSEADKLHLASLEEGHPDNAGASLVGGLVIGLHEDDETQMIRV PNADIDVVVVIPFYEVLTRDARDVLPKEFPYADAVKASAVSNILIAAIMSKDWPLVGK IMKKDMFHQPYRAMLVPELSKVEHVAEMKGAYGTALSGAGPTILVMTEKGKGEELKEQ LALHFPHCEVDALTVPKEGSIIERNPLYQVKSV*" /label="thrB CDS" gene complement(2831088..2832017) /gene="thrB" /locus_tag="BSU_32240" /old_locus_tag="BSU32240" /label="thrB gene" downshifts complement(2831101) /Source="Nicolas_upshifts" /id="D1675" /incds=0 /nref=222 /ntot=261 /MaxReadThrough="2.39521" /MaxDrop="7.03759" /score="15.5945196" /energy="-10.3" /TU="NA" /idTUdmin="U2530" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(2832014..2833072) /gene="thrC" /locus_tag="BSU_32250" /old_locus_tag="BSU32250" /EC_number="4.2.3.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3098560, 3139660, 8768250" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3098560, 3139660, 8768250; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine synthase" /protein_id="NP_391105.1" /db_xref="EnsemblGenomes-Gn:BSU32250" /db_xref="EnsemblGenomes-Tr:CAB15215" /db_xref="GOA:P04990" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR004450" /db_xref="InterPro:IPR026260" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10461" /db_xref="UniProtKB/Swiss-Prot:P04990" /translation="MWKGLIHQYKEFLPVTDQTPALTLHEGNTPLIHLPKLSEQLGIE LHVKTEGVNPTGSFKDRGMVMAVAKAKEEGNDTIMCASTGNTSAAAAAYAARANMKCI VIIPNGKIAFGKLAQAVMYGAEIIAIDGNFDDALKIVRSICEKSPIALVNSVNPYRIE GQKTAAFEVCEQLGEAPDVLAIPVGNAGNITAYWKGFKEYHEKNGTGLPKMRGFEAEG AAAIVRNEVIENPETIATAIRIGNPASWDKAVKAAEESNGKIDEVTDDEILHAYQLIA RVEGVFAEPGSCASIAGVLKQVKSGEIPKGSKVVAVLTGNGLKDPNTAVDISEIKPVT LPTDEDSILEYVKGAARV*" /label="thrC CDS" gene complement(2832014..2833072) /gene="thrC" /locus_tag="BSU_32250" /old_locus_tag="BSU32250" /label="thrC gene" CDS complement(2833072..2834373) /gene="hom" /locus_tag="BSU_32260" /old_locus_tag="BSU32260" /EC_number="1.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3139660, 27299409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3139660, 27299409; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homoserine dehydrogenase" /protein_id="NP_391106.1" /db_xref="EnsemblGenomes-Gn:BSU32260" /db_xref="EnsemblGenomes-Tr:CAB15216" /db_xref="GOA:P19582" /db_xref="InterPro:IPR001342" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005106" /db_xref="InterPro:IPR016204" /db_xref="InterPro:IPR019811" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10460" /db_xref="UniProtKB/Swiss-Prot:P19582" /translation="MKAIRVGLLGLGTVGSGVVKIIQDHQDKLMHQVGCPVTIKKVLV KDLEKKREVDLPKEVLTTEVYDVIDDPDVDVVIEVIGGVEQTKQYLVDALRSKKHVVT ANKDLMAVYGSELLAEAKENGCDIYFEASVAGGIPILRTLEEGLSSDRITKMMGIVNG TTNFILTKMIKEKSPYEEVLKEAQDLGFAEADPTSDVEGLDAARKMAILARLGFSMNV DLEDVKVKGISQITDEDISFSKRLGYTMKLIGIAQRDGSKIEVSVQPTLLPDHHPLSA VHNEFNAVYVYGEAVGETMFYGPGAGSMPTATSVVSDLVAVMKNMRLGVTGNSFVGPQ YEKNMKSPSDIYAQQFLRIHVKDEVGSFSKITSVFSERGVSFEKILQLPIKGHDELAE IVIVTHHTSEADFSDILQNLNDLEVVQEVKSTYRVEGNGWS*" /label="hom CDS" gene complement(2833072..2834373) /gene="hom" /locus_tag="BSU_32260" /old_locus_tag="BSU32260" /label="hom gene" promotor_-35 2834258..2834267 /Source="Nicolas_upshift_promotors" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2834282..2834301 /Source="Nicolas_upshift_promotors" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2834289 /Source="Nicolas_upshifts" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2834374..2834455) /Source="Nicolas_S_feature" /locus_tag="new_3316130_3316211_c" /HighExp="T3.0H, T2.30H, T3.30H, S2, C90, T4.0H, BMM, SMM, MG 120, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1245" promotor_-10 complement(2834440..2834459) /Source="Nicolas_upshift_promotors" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2834455) /Source="Nicolas_upshifts" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2834457..2834573) /Source="Nicolas_S_feature" /locus_tag="new_3316213_3316329_c" /HighExp="S5, S3, S4, S7, S6, S8, BT, B36, LoTm, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1246" promotor_-35 complement(2834474..2834481) /Source="Nicolas_upshift_promotors" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2834574..2835593) /gene="cotNH" /locus_tag="BSU_32270" /old_locus_tag="BSU32270" /function="16.3: Control" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15231775, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231775, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat-associated protein" /protein_id="NP_391107.1" /db_xref="EnsemblGenomes-Gn:BSU32270" /db_xref="EnsemblGenomes-Tr:CAB15217" /db_xref="GOA:O32123" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014254" /db_xref="SubtiList:BG14044" /db_xref="UniProtKB/Swiss-Prot:O32123" /translation="MVKGTIKEKYGIHIRQLSMYQHTYQCFQTPNSYFLIVPVSQFSE TELAELYYMSQYLQEQSDPYVSVFIFTKEGELTFEHEGKTYALLKAAPPYSNRAFSIG AELAEFHRKGRGYPYEVKAAGRIGQWKDLWGKRIDQLEAFWQRKVQTPPHEPFDKKMI ESFPYYLGLSENAIQYLVDTELDDKPQAADSGTICHQRMERHTWSPESLIRIPADWVF DHASRDLAEYMRHTFLHHRQDFNQQGFLFLQEYEQVTPLSSFSKRLLYSRLLFPLHYF EIVESYYMSSESEKHYFEEQLDFILNDCGRYEQFLNTAQEFMNMRAQKLFVPRVSWLG KGSSR*" /label="cotNH CDS" gene complement(2834574..2835593) /gene="cotNH" /locus_tag="BSU_32270" /old_locus_tag="BSU32270" /label="cotNH gene" promotor_-35 2835401..2835406 /Source="Nicolas_upshift_promotors" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2835422..2835440 /Source="Nicolas_upshift_promotors" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2835426 /Source="Nicolas_upshifts" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2835616..2835634) /Source="Nicolas_upshift_promotors" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2835623) /Source="Nicolas_upshifts" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2835632..2835637 /Source="Nicolas_upshift_promotors" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2835650..2835655) /Source="Nicolas_upshift_promotors" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2835653..2835717 /Source="Nicolas_S_feature" /locus_tag="new_3317409_3317473" /HighExp="S4, S5, S3, S6, S7, B36, S8, LoTm, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1247" promotor_-10 2835653..2835671 /Source="Nicolas_upshift_promotors" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2835653 /Source="Nicolas_upshifts" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2835690..2835699 /Source="Nicolas_upshift_promotors" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2835712..2835731 /Source="Nicolas_upshift_promotors" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2835719 /Source="Nicolas_upshifts" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="upshifts" CDS 2835746..2836246 /gene="yutG" /locus_tag="BSU_32280" /old_locus_tag="BSU32280" /function="16.8: Protect" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatidylglycerophosphatase" /protein_id="NP_391108.1" /db_xref="EnsemblGenomes-Gn:BSU32280" /db_xref="EnsemblGenomes-Tr:CAB15218" /db_xref="GOA:O32124" /db_xref="InterPro:IPR007686" /db_xref="InterPro:IPR026038" /db_xref="InterPro:IPR036681" /db_xref="SubtiList:BG14043" /db_xref="UniProtKB/Swiss-Prot:O32124" /translation="MSENEQFSQMEAKARARMKERGVEVSDIAELVFFLQKKYHPDLT IDECTLNVNRVLAKREVQNAILTGIELDVLAEQKKLSEPLQTMLEIDESLYGVDEVLA FSIVNIYGSIGFTNYGYIDKEKPGILKRLNDKSTGECHTFLDDIVGAISAAASSRLAH RARHTE*" /label="yutG CDS" gene 2835746..2836246 /gene="yutG" /locus_tag="BSU_32280" /old_locus_tag="BSU32280" /label="yutG gene" CDS complement(2836273..2837043) /gene="nucF" /locus_tag="BSU_32290" /old_locus_tag="BSU32290" /EC_number="3.1.3.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15664928, 16766528, 27907199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15664928, 16766528, 27907199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5' nucleotidase, promiscuous" /protein_id="NP_391109.1" /db_xref="EnsemblGenomes-Gn:BSU32290" /db_xref="EnsemblGenomes-Tr:CAB15219" /db_xref="GOA:O32125" /db_xref="InterPro:IPR006354" /db_xref="InterPro:IPR006357" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3PDW" /db_xref="SubtiList:BG14042" /db_xref="UniProtKB/Swiss-Prot:O32125" /translation="MKTYKGYLIDLDGTMYNGTEKIEEACEFVRTLKDRGVPYLFVTN NSSRTPKQVADKLVSFDIPATEEQVFTTSMATAQHIAQQKKDASVYVIGEEGIRQAIE ENGLTFGGENADFVVVGIDRSITYEKFAVGCLAIRNGARFISTNGDIAIPTERGLLPG NGSLTSVLTVSTGVQPVFIGKPESIIMEQAMRVLGTDVSETLMVGDNYATDIMAGINA GMDTLLVHTGVTKREHMTDDMEKPTHAIDSLTEWIPYI*" /label="nucF CDS" gene complement(2836273..2837043) /gene="nucF" /locus_tag="BSU_32290" /old_locus_tag="BSU32290" /label="nucF gene" downshifts complement(2836301) /Source="Nicolas_upshifts" /id="D1676" /incds=0 /nref=137 /ntot=243 /MaxReadThrough="2.15034" /MaxDrop="4.82801" /score="8.09889752" /energy="-15.6" /TU="NA" /idTUdmin="U2535" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2837072..2837506) /gene="yutE" /locus_tag="BSU_32300" /old_locus_tag="BSU32300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27907199" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391110.1" /db_xref="EnsemblGenomes-Gn:BSU32300" /db_xref="EnsemblGenomes-Tr:CAB15220" /db_xref="InterPro:IPR008201" /db_xref="PDB:1YLM" /db_xref="SubtiList:BG14041" /db_xref="UniProtKB/Swiss-Prot:O32126" /translation="MYFVDRSKIEKTLGFFEHQLALFDSQTDWQSEIGELALQRIGHL LIECILDTGNDMIDGFIMRDPGSYDDIMDILVDEKVVTEKEGDELKKLIAYRKTLVQQ YLLADSGELYRLIKAHQTALQDFPKRIRSYLETELGPVSAFK*" /label="yutE CDS" gene complement(2837072..2837506) /gene="yutE" /locus_tag="BSU_32300" /old_locus_tag="BSU32300" /label="yutE gene" CDS complement(2837530..2837805) /gene="yutD" /locus_tag="BSU_32310" /old_locus_tag="BSU32310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12770717, 27907199" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391111.2" /db_xref="EnsemblGenomes-Gn:BSU32310" /db_xref="EnsemblGenomes-Tr:CAB15221" /db_xref="InterPro:IPR009370" /db_xref="PDB:2KL5" /db_xref="SubtiList:BG14040" /db_xref="UniProtKB/Swiss-Prot:O32127" /translation="MILIQNAEFELVHNFKDGFNEEAFKARYSDILNKYDYIVGDWGY GQLRLKGFFDDQNQKATFETKISTLDEYIYEYCNFGCAYFVLKRIRK*" /label="yutD CDS" gene complement(2837530..2837805) /gene="yutD" /locus_tag="BSU_32310" /old_locus_tag="BSU32310" /label="yutD gene" promotor_-10 complement(2837825..2837844) /Source="Nicolas_upshift_promotors" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2837850) /Source="Nicolas_upshifts" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2837852..2838544) /Source="Nicolas_S_feature" /locus_tag="new_3319608_3320300_c" /HighExp="G135, G150, G180, H2O2, LBGtran, LBGexp, Paraq, dia15, C90, HiOs" /AntisenseName="yutC" /AntisenseCor="-0.57886192731570996" /AntisenseRegPval="-24.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1248" promotor_-35 complement(2837858..2837865) /Source="Nicolas_upshift_promotors" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2837868..2837874 /Source="Nicolas_upshift_promotors" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2837889..2837900 /Source="Nicolas_upshift_promotors" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2837897 /Source="Nicolas_upshifts" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="upshifts" CDS 2837920..2838552 /gene="yutC" /locus_tag="BSU_32320" /old_locus_tag="BSU32320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative sporulation-related lipoprotein" /protein_id="NP_391112.1" /db_xref="EnsemblGenomes-Gn:BSU32320" /db_xref="EnsemblGenomes-Tr:CAB15222" /db_xref="GOA:O32128" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG14039" /db_xref="UniProtKB/Swiss-Prot:O32128" /translation="MKRTAVSLCLLTGLLSGCGGAGLDNAQNVRNQTQNQTKPIHVSD RNEAFNRHNENEQFGYVRYQKEQFDGEQQKTPVMNREETAHMISSLTVQLPHIQDAAT LVTDREALVVYKTDSKNRELTADQVKKTAASVIPRYYHVYISDNPNHMQSVENYSNLG SGSRDIREIMSGTIQEMKTSPQGSPVSENENANGETRQDMKIDRNDKNAR*" /label="yutC CDS" gene 2837920..2838552 /gene="yutC" /locus_tag="BSU_32320" /old_locus_tag="BSU32320" /label="yutC gene" downshifts 2838513 /Source="Nicolas_upshifts" /id="D1677" /incds=0 /nref=9 /ntot=30 /MaxReadThrough="1.84979" /MaxDrop="3.55825" /score="-2.38634221" /energy="-9.6" /TU="NA" /idTUdmin="U2536" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2838568..2839464) /gene="lipA" /locus_tag="BSU_32330" /old_locus_tag="BSU32330" /EC_number="2.8.1.8" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15362861, 16835858, 19028902, 19820084, 25341020; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lipoyl synthase (lipoic acid synthetase)" /protein_id="NP_391113.2" /db_xref="EnsemblGenomes-Gn:BSU32330" /db_xref="EnsemblGenomes-Tr:CAB15223" /db_xref="GOA:O32129" /db_xref="InterPro:IPR003698" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR031691" /db_xref="SubtiList:BG14038" /db_xref="UniProtKB/Swiss-Prot:O32129" /translation="MAKKDEHLRKPEWLKIKLNTNENYTGLKKLMRENNLHTVCEEAK CPNIHECWAVRRTATFMILGSVCTRACRFCAVKTGLPTELDLQEPERVADSVALMNLK HAVITAVARDDQKDGGAGIFAETVRAIRRKSPFTTIEVLPSDMGGNYDNLKTLMDTRP DILNHNIETVRRLTPRVRARATYDRSLEFLRRAKEMQPDIPTKSSIMIGLGETKEEII EVMDDLLANNVDIMAIGQYLQPTKKHLKVQKYYHPDEFAELKEIAMQKGFSHCEAGPL VRSSYHADEQVNEASKKRQAQA*" /label="lipA CDS" gene complement(2838568..2839464) /gene="lipA" /locus_tag="BSU_32330" /old_locus_tag="BSU32330" /label="lipA gene" downshifts complement(2838589) /Source="Nicolas_upshifts" /id="D1678" /incds=0 /nref=186 /ntot=261 /MaxReadThrough="3.83236" /MaxDrop="5.33309" /score="14.803008" /energy="-9.6" /TU="U2537" /idTUdmin="U2537" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" S_feature complement(2839465..2839599) /Source="Nicolas_S_feature" /locus_tag="new_3321221_3321355_c" /HighExp="HiOs, LBGtran, dia15, dia5, C90, Diami, dia0, LBGexp, Heat, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1249" promotor_-10 complement(2839586..2839605) /Source="Nicolas_upshift_promotors" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="promotor_-10" upshifts complement(2839599) /Source="Nicolas_upshifts" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="upshifts" promotor_-35 complement(2839621..2839625) /Source="Nicolas_upshift_promotors" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="promotor_-35" promotor_-35 2839639..2839645 /Source="Nicolas_upshift_promotors" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2839659..2839670 /Source="Nicolas_upshift_promotors" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2839671 /Source="Nicolas_upshifts" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="upshifts" CDS 2839699..2840679 /gene="lytH" /locus_tag="BSU_32340" /old_locus_tag="BSU32340" /EC_number="3.4.-.-" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12813075; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific L-Ala-D-Glu endopeptidase" /protein_id="NP_391114.2" /db_xref="EnsemblGenomes-Gn:BSU32340" /db_xref="EnsemblGenomes-Tr:CAB15224" /db_xref="GOA:O32130" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="SubtiList:BG13975" /db_xref="UniProtKB/Swiss-Prot:O32130" /translation="MKVLLSALLLLLFAFEPSASGKKLSDPVLSKRMELYHKIEAVTQ IPWYALAAVDQYEENVRSNRKDLPEKAGIISIYIPDDIWSGPENPNPKDDAPLSIKVF DGIGMDGDGDGKAEVSNDEDILYTFSQYLLSYGTDEDNIRIGLWNYYRRDQTVGIISE FMKLFKAYGHIDLGEHAFPLPIRTDYSYRSTWGDARGFGGRRIHEGTDIFAHYGLPVK STCYGVVEMKGWNRFGGWRIGIRDINNTYHYFAHLNGFAKGIKTGQIVEPGQVIGSVG SSGYGPPGTAGKFPPHLHYGMYKDNGRTEWSFDPYPHLRAWERYEYQKKK*" /label="lytH CDS" gene 2839699..2840679 /gene="lytH" /locus_tag="BSU_32340" /old_locus_tag="BSU32340" /label="lytH gene" upshifts complement(2839777) /Source="Nicolas_upshifts" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2839791..2839810) /Source="Nicolas_upshift_promotors" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2839827..2839830) /Source="Nicolas_upshift_promotors" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2840671 /Source="Nicolas_upshifts" /id="D1679" /incds=0 /nref=35 /ntot=74 /MaxReadThrough="0.613989999999999" /MaxDrop="8.59238" /score="-3.31011906" /energy="-20" /TU="NA" /idTUdmin="U2538" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(2840707..2841471) /gene="fisB" /locus_tag="BSU_32350" /old_locus_tag="BSU32350" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12662922, 23388828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 23388828; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein required for membrane fission during spore formation" /protein_id="NP_391115.1" /db_xref="EnsemblGenomes-Gn:BSU32350" /db_xref="EnsemblGenomes-Tr:CAB15225" /db_xref="GOA:O32131" /db_xref="InterPro:IPR014197" /db_xref="SubtiList:BG13976" /db_xref="UniProtKB/Swiss-Prot:O32131" /translation="MPRYRGPFRKRGPLPFRYVMLLSVVFFILSTTVSLWMINGSIKP VLMDIGEMETKRIATEVIQDSIEDYMSDSENMKDMFQMNSDENGNLTTIDFNTQVVNS VKTKVTKQLQAHLKEMETHTGHSGASENIMINIPLGQVTGNSLLGNLGPKIPVRFNLI GDAFTDVKTKIKPYGINNALIDISIFVEIKVKVIIPFASKTAVVTNNVPVSIKAVQGE VPQFYNGSGGSGVTPSVQLPSSKENGADSKKEKSSK*" /label="fisB CDS" gene complement(2840707..2841471) /gene="fisB" /locus_tag="BSU_32350" /old_locus_tag="BSU32350" /label="fisB gene" downshifts complement(2840723) /Source="Nicolas_upshifts" /id="D1680" /incds=0 /nref=74 /ntot=226 /MaxReadThrough="3.15258" /MaxDrop="6.53891" /score="23.5286262" /energy="-12.4" /TU="NA" /idTUdmin="U2540" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2841485..2841503) /Source="Nicolas_upshift_promotors" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2841493) /Source="Nicolas_upshifts" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2841519..2841524) /Source="Nicolas_upshift_promotors" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2841544..2841849) /gene="yunC" /locus_tag="BSU_32360" /old_locus_tag="BSU32360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391116.1" /db_xref="EnsemblGenomes-Gn:BSU32360" /db_xref="EnsemblGenomes-Tr:CAB15226" /db_xref="InterPro:IPR014931" /db_xref="InterPro:IPR036493" /db_xref="SubtiList:BG13977" /db_xref="UniProtKB/Swiss-Prot:O32132" /translation="MVNLTPIMIEGQPFTAVTVKLPKTNFMAVANDHGYIMCGALDVA LLNEKLKERGIVAGRAVGVRTIDQLLDAPLESVTYAAEDLGIKVGMSGREALLKMMK* " /label="yunC CDS" gene complement(2841544..2841849) /gene="yunC" /locus_tag="BSU_32360" /old_locus_tag="BSU32360" /label="yunC gene" downshifts complement(2841552) /Source="Nicolas_upshifts" /id="D1681" /incds=0 /nref=3 /ntot=128 /MaxReadThrough="5.18714" /MaxDrop="3.9347" /score="-2.65376612" /energy="-18.9" /TU="U2541,U2543,U2544" /idTUdmin="U2540" /TUdmin="-829" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2841863..2841882) /Source="Nicolas_upshift_promotors" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2841886) /Source="Nicolas_upshifts" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2841896..2841904) /Source="Nicolas_upshift_promotors" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2841914..2843302) /gene="yunD" /locus_tag="BSU_32370" /old_locus_tag="BSU32370" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nuclease/nucleotidase/phosphoesterase" /protein_id="NP_391117.1" /db_xref="EnsemblGenomes-Gn:BSU32370" /db_xref="EnsemblGenomes-Tr:CAB15227" /db_xref="GOA:O32133" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR011240" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036907" /db_xref="SubtiList:BG13978" /db_xref="UniProtKB/Swiss-Prot:O32133" /translation="MKEKLRLYHTNDLHSHFENWPKIVDYIEQKRKEHQSDGEETLVF DIGDHLDRFQFVTEATFGKANVDLLNRLHIDGAAIGNNEGITLPHEELAALYDHAEFP VIVSNLFDKNGNRPSWAVPYHIKSLKNGMSIAFLGVTVPYYPVYDKLGWTVTDALESI KETILEVKGQADIIVLLSHLGILDDQAVAEAVPEIDVILESHTHHLLEDGQVVNGVLL ASAEKYGHYVGCVEITVDSVQRSINSKTASVQNMAEWTGESAETKAFLNEKEREAEEK LSDAVAELAQDAEVKWFEESELPLLLAYALKEWCETDISMVNSGVILGPLKAGPVTKL DLHRICPHPINPVAVRLTGEELKETIVHAASEQMEQLRIKGLGFRGEVMGKMVYAGVE VETKRLDDGITHVTRITLNGEDIEKHKQYSVAVLDMFTLGKLFPLIRDAAEKEYFMPE FLRDLLAWKLAQ*" /label="yunD CDS" gene complement(2841914..2843302) /gene="yunD" /locus_tag="BSU_32370" /old_locus_tag="BSU32370" /label="yunD gene" CDS complement(2843322..2844143) /gene="yunE" /locus_tag="BSU_32380" /old_locus_tag="BSU32380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391118.1" /db_xref="EnsemblGenomes-Gn:BSU32380" /db_xref="EnsemblGenomes-Tr:CAB15228" /db_xref="GOA:O32134" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13979" /db_xref="UniProtKB/Swiss-Prot:O32134" /translation="MSFVILVVLGLIAGTVGSLIGLGGGIVIVPSLMFLSTVTQLFQD VTPQVAIGTSLLVIIFTGLSSTLAYIKYKTVDYKSGLIFFIGSGPGSMIGAYVSKLFN SNSFSVWFGIFMILISLSLMLKAKARPINKAHKGIIRTFQDDAGEPYTYSYQASVGIA IAFVVGFLGGLFGIGGGSLMVPAMMLLFLFPPKVAVATSMFIIFLSSMTGSVSHMISG HVNWLYALALVPGAWFGGKLGAAINRKMQTKTIVMIMRIVLILIGCQLIYEGIFS*" /label="yunE CDS" gene complement(2843322..2844143) /gene="yunE" /locus_tag="BSU_32380" /old_locus_tag="BSU32380" /label="yunE gene" CDS complement(2844161..2845009) /gene="yunF" /locus_tag="BSU_32390" /old_locus_tag="BSU32390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391119.2" /db_xref="EnsemblGenomes-Gn:BSU32390" /db_xref="EnsemblGenomes-Tr:CAB15229" /db_xref="InterPro:IPR002763" /db_xref="InterPro:IPR036520" /db_xref="SubtiList:BG13980" /db_xref="UniProtKB/Swiss-Prot:O32135" /translation="MIYIGLTGWGDHDSIYPPKTASQKKLQAYSSHFPIVELDASFYA IQPARNNEKWVKETPETFQFIVKAYQGMTGHQRGEIPFDSKEEMFDAFKVSLTPYLHS NKLAMVLFQFPPWFDCKKENVAYLRWCKHQMGDIPCALEFRNRSWFSPPFYEQTLSFM KAEGWIHSVCDEPQIGEGSVPTVLRATDENKTLVRFHGRNKQGWMKPDGGKNWREVRY LYRYNQQELEDWKKHLNELQQQCKDVFVLFNNNSGGDAADNGKQMLELLDIEYSGLAP RQLDLF*" /label="yunF CDS" gene complement(2844161..2845009) /gene="yunF" /locus_tag="BSU_32390" /old_locus_tag="BSU32390" /label="yunF gene" promotor_-35 2844528..2844533 /Source="Nicolas_upshift_promotors" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2844549..2844567 /Source="Nicolas_upshift_promotors" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2844563 /Source="Nicolas_upshifts" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2845020..2845039) /Source="Nicolas_upshift_promotors" /id="U2543" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1989 /SigmaFactorBS="gcgtgaggcattttcccgccatatgaacagcatttccgagga aacctgaaaacacgTGTGATAAACTGGAAGAGAGgtgaatgagtgtgatttatatcgg a" /listShort="yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2845035) /Source="Nicolas_upshifts" /id="U2543" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1989 /SigmaFactorBS="gcgtgaggcattttcccgccatatgaacagcatttccgagga aacctgaaaacacgTGTGATAAACTGGAAGAGAGgtgaatgagtgtgatttatatcgg a" /listShort="yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2845047..2845394) /gene="yunG" /locus_tag="BSU_32400" /old_locus_tag="BSU32400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391120.1" /db_xref="EnsemblGenomes-Gn:BSU32400" /db_xref="EnsemblGenomes-Tr:CAB15230" /db_xref="SubtiList:BG13981" /db_xref="UniProtKB/Swiss-Prot:O32136" /translation="MEHVKYILKQSWSRHSSSKWTEECPSCGQCGVTALVIQDHFGGT IFKTRVDESWHFYNSINGVVYDFTSEQFQAPIEYQHIPSSREEAFLDTNEEQYQHLRE AFSRHMNSISEET*" /label="yunG CDS" gene complement(2845047..2845394) /gene="yunG" /locus_tag="BSU_32400" /old_locus_tag="BSU32400" /label="yunG gene" promotor_-10 complement(2845407..2845426) /Source="Nicolas_upshift_promotors" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2845426) /Source="Nicolas_upshifts" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2845440..2845446) /Source="Nicolas_upshift_promotors" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2845491..2846831) /gene="pucH" /locus_tag="BSU_32410" /old_locus_tag="BSU32410" /EC_number="3.5.2.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="allantoinase" /protein_id="NP_391121.1" /db_xref="EnsemblGenomes-Gn:BSU32410" /db_xref="EnsemblGenomes-Tr:CAB15231" /db_xref="GOA:O32137" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR017593" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG13982" /db_xref="UniProtKB/Swiss-Prot:O32137" /translation="MAYDMVIKGAKAVTPDGVIEADIVVQNGVIAEIGSDIEASGTEI IQADGKYVFPGVIDCHVHFNEPGREDWEGFETGSQMMAAGGCTTYFDMPLNCIPSTVT AEHLLAKAELGRQKSAVDFALWGGLVPGHIEDIRPMAEAGAIGFKAFLSKSGTDEFRS VDERTLLKGMAEIAAAGKILALHAESDAITSYLQMVLANKGKVDADAYAASRPEEAEV EAVYRTIQYAKVTGCPVHFVHISTAKAVRLIREAKQEGLDVSVETCPHYVLFSHDDLR QRGSVAKCAPPLRSRQSKETLIETLIAGDIDMVSSDHSPCRPSLKREDNMFLSWGGIS GGQFTLLGMLELALEHQIPFETIAEWTAAAPAKRFGLQKKGRLEAGCDADFVLVSMEP YTVTRESMFAKHKKSIYEGHTFPCSISATYSKGRCVYNDGEKVTEIDGALVVPS*" /label="pucH CDS" gene complement(2845491..2846831) /gene="pucH" /locus_tag="BSU_32410" /old_locus_tag="BSU32410" /label="pucH gene" downshifts complement(2845519) /Source="Nicolas_upshifts" /id="D1682" /incds=0 /nref=5 /ntot=28 /MaxReadThrough="0.88847" /MaxDrop="3.89144" /score="36.6188375" /energy="-15.4" /TU="NA" /idTUdmin="U2540" /TUdmin="-4796" /isTUend="FALSE" /label="downshifts" downshifts complement(2846575) /Source="Nicolas_upshifts" /id="D1683" /incds=1 /nref=1 /ntot=7 /MaxReadThrough="3.38784" /MaxDrop="3.36547" /score="36.6188375" /energy="-15.4" /TU="NA" /idTUdmin="U2540" /TUdmin="-5852" /isTUend="FALSE" /label="downshifts" promotor_-35 2846888..2846894 /Source="Nicolas_upshift_promotors" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2846908..2846927 /Source="Nicolas_upshift_promotors" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2846910..2846928) /Source="Nicolas_upshift_promotors" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2846916 /Source="Nicolas_upshifts" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="upshifts" S_feature 2846917..2847005 /Source="Nicolas_S_feature" /locus_tag="new_3328673_3328761" /HighExp="BT, Cold, S0, LBGexp, S1, Lbtran, G150, T-1.40H, G180, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.961" /TUlongSig="NA" /TUlongPSig="NA" /label="S1250" upshifts complement(2846927) /Source="Nicolas_upshifts" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2846944..2846949) /Source="Nicolas_upshift_promotors" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2847006..2848601 /gene="pucR" /locus_tag="BSU_32420" /old_locus_tag="BSU32420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039, 12374841" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039, 12374841; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the purine degradation operon" /protein_id="NP_391122.1" /db_xref="EnsemblGenomes-Gn:BSU32420" /db_xref="EnsemblGenomes-Tr:CAB15232" /db_xref="GOA:O32138" /db_xref="InterPro:IPR012914" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR028979" /db_xref="SubtiList:BG13983" /db_xref="UniProtKB/Swiss-Prot:O32138" /translation="MNILDVMKIPAFENANLIAGKAGGEREVQHVNMMDAPDIVDFLH KNELLVTTAYHLKDHPHQLSELIRQMAKRGCAGLGIKTKRYLEDIPKEIIELADSYAF PIIELPEHIRLGDIVNATLSHILDMRSNELQQAIYAHKKFTNHIMSGKGLQSLLKKVS DILQLPVLLLDQHAKMLSASHQISVETEKLKGTLNTVSGPFFTCFSTISDQKTYSVLP IYNHEKNCGYLLIPDMVQAGDKGLILTIEQAANVISFELLKENALKQFSRRARNEFFN NFIERTFSSDDEIKNRAKEFKLRWDQKYMCIAGKLDRNDESISFTENQLASDSVFEFL EGELSAFPFPPHFFMKGNVGIILIEATDSWSEMHASVISFLEQFQTQVSAQFKRTVSF GISNICQKLIDVPDAFTEASDALQSGHLSRSTAFIQVYHAKDVPELLRLLPVEDLKKF YNSTLQSLAEKQQEDQSLLHTLSVYLETHCQISETAKRLYVHRNTVIYRLEKCEELLG KSLKDPETTMRLRLALRMQRLIS*" /label="pucR CDS" gene 2847006..2848601 /gene="pucR" /locus_tag="BSU_32420" /old_locus_tag="BSU32420" /label="pucR gene" CDS 2848746..2850095 /gene="pucJ" /locus_tag="BSU_32430" /old_locus_tag="BSU32430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uric acid permease" /protein_id="NP_391123.1" /db_xref="EnsemblGenomes-Gn:BSU32430" /db_xref="EnsemblGenomes-Tr:CAB15233" /db_xref="GOA:O32139" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG13984" /db_xref="UniProtKB/Swiss-Prot:O32139" /translation="MKKRSFKVFTLSLQHVLAMYAGAILVPLLVGRALNVTTEQLSYL LAIDLLTCGVATLLQTLRGTYIGIGLPVMLGSSFVAVTPMIAIGSNYGIHAIYGSIIA AGVFIFLFARFFGKLTVLFPPVVTGTVVTLIGLSLVPTGVKNMAGGEKINGSANPEYG SLENLLLSVGVLVLILVLNRFLKGFARTLSVLIGIAAGTAAAAIMGKVSFSSVTEAPF FQIPKPFYFGAPAFEIGPILTMLIVGIVIIVESTGVFYAIGKICGRPLTDKDLVKGYR AEGIAILIGGLFNAFPYNTFAQNAGLLQLTKVKTRNIVVTAGCILVCLGLIPKIAALA SAVPAAVLGGATVVMFGMVIASGVKMLSTADLKNQYHLLTIACSIALGIGASTAPGIF AEFPAPIRILVSDGTITGSLTAIFLNLFFSLRDKKELTAQQTELPVLEHTLALEKEV* " /label="pucJ CDS" gene 2848746..2850095 /gene="pucJ" /locus_tag="BSU_32430" /old_locus_tag="BSU32430" /label="pucJ gene" CDS 2850101..2851393 /gene="pucK" /locus_tag="BSU_32440" /old_locus_tag="BSU32440" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uric acid permease subunit" /protein_id="NP_391124.1" /db_xref="EnsemblGenomes-Gn:BSU32440" /db_xref="EnsemblGenomes-Tr:CAB15234" /db_xref="GOA:O32140" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG13985" /db_xref="UniProtKB/Swiss-Prot:O32140" /translation="MKEQHNALQLMMLGLQHMLAMYAGAILVPLIVGAAIGLNAGQLT YLIAIDLFMCGAATLLQLWRNRYFGIGLPVVLGCTFTAVGPMISIGSTYGVPAIYGAI IAAGLIVVLAAGFFGKLVRFFPPVVTGSVVMIIGISLIPTAMNNLAGGEGSKEFGSLD NVLLGFGVTAFILLLFYFFKGFIRSIAILLGLIAGTAAAYFMGKVDFSEVLEASWLHV PSLFYFGPPTFELPAVVTMLLVAIVSLVESTGVYFALADITNRRLSEKDLEKGYRAEG LAILLGGLFNAFPYTAFSQNVGIVQLSKMKSVNVIAITGIILVAIGLVPKAAALTTVI PTPVLGGAMIVMFGMVISYGIKMLSSVDLDSQGNLLIIASSVSLGLGATTVPALFSSL SGAASVLAGSGIVIGSLTAIALHAFFQTKQPNSADIKT*" /label="pucK CDS" gene 2850101..2851393 /gene="pucK" /locus_tag="BSU_32440" /old_locus_tag="BSU32440" /label="pucK gene" CDS 2851406..2852890 /gene="pucL" /locus_tag="BSU_32450" /old_locus_tag="BSU32450" /EC_number="1.7.3.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 12823818, 17567580, 20168977, 23760935, 28531234" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12823818, 17567580, 20168977, 23760935, 28531234; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="urate oxidase with peroxide reductase N-terminaldomain" /protein_id="NP_391125.1" /db_xref="EnsemblGenomes-Gn:BSU32450" /db_xref="EnsemblGenomes-Tr:CAB15235" /db_xref="GOA:O32141" /db_xref="InterPro:IPR002042" /db_xref="InterPro:IPR017580" /db_xref="InterPro:IPR018020" /db_xref="InterPro:IPR019842" /db_xref="InterPro:IPR036778" /db_xref="SubtiList:BG13986" /db_xref="UniProtKB/Swiss-Prot:O32141" /translation="MFTMDDLNQMDTQTLTDTLGSIFEHSSWIAERSAALRPFSSLSD LHRKMTGIVKAADRETQLDLIKKHPRLGTKKTMSDDSVREQQNAGLGKLEQQEYEEFL MLNEHYYDRFGFPFILAVKGKTKQDIHQALLARLESERETEFQQALIEIYRIARFRLA DIITEKGETQMKRTMSYGKGNVFAYRTYLKPLTGVKQIPESSFAGRDNTVVGVDVTCE IGGEAFLPSFTDGDNTLVVATDSMKNFIQRHLASYEGTTTEGFLHYVAHRFLDTYSHM DTITLTGEDIPFEAMPAYEEKELSTSRLVFRRSRNERSRSVLKAERSGNTITITEQYS EIMDLQLVKVSGNSFVGFIRDEYTTLPEDGNRPLFVYLNISWQYENTNDSYASDPARY VAAEQVRDLASTVFHELETPSIQNLIYHIGCRILARFPQLTDVSFQSQNHTWDTVVEE IPGSKGKVYTEPRPPYGFQHFTVTREDAEKEKQKAAEKCRSLKA*" /label="pucL CDS" gene 2851406..2852890 /gene="pucL" /locus_tag="BSU_32450" /old_locus_tag="BSU32450" /label="pucL gene" CDS 2852890..2853234 /gene="pucM" /locus_tag="BSU_32460" /old_locus_tag="BSU32460" /EC_number="3.5.2.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 16098976, 16782815, 21795808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 16098976, 16782815, 21795808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-hydroxyisourate hydrolase; also uricase subunit" /protein_id="NP_391126.2" /db_xref="EnsemblGenomes-Gn:BSU32460" /db_xref="EnsemblGenomes-Tr:CAB15236" /db_xref="GOA:O32142" /db_xref="InterPro:IPR000895" /db_xref="InterPro:IPR014306" /db_xref="InterPro:IPR023416" /db_xref="InterPro:IPR023418" /db_xref="InterPro:IPR023419" /db_xref="InterPro:IPR036817" /db_xref="PDB:2H0E" /db_xref="PDB:2H0F" /db_xref="PDB:2H0J" /db_xref="SubtiList:BG13987" /db_xref="UniProtKB/Swiss-Prot:O32142" /translation="MGKLTTHILDLTCGKPAANVKIGLKRLGESIMKEVYTNNDGRVD VPLLAGEELMSGEYVMEFHAGDYFASKNMNAADQPFLTIVTVRFQLADPDAHYHIPLL LSPFGYQVYRGS*" /label="pucM CDS" gene 2852890..2853234 /gene="pucM" /locus_tag="BSU_32460" /old_locus_tag="BSU32460" /label="pucM gene" promotor_-35 2852956..2852959 /Source="Nicolas_upshift_promotors" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2852977..2852996 /Source="Nicolas_upshift_promotors" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2852989 /Source="Nicolas_upshifts" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2853209 /Source="Nicolas_upshifts" /id="D1684" /incds=0 /nref=3 /ntot=90 /MaxReadThrough="1.80149" /MaxDrop="3.57243" /score="20.0549891" /energy="-14.2" /TU="NA" /idTUdmin="U2547" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2853250..2853637) /Source="Nicolas_S_feature" /locus_tag="new_3335006_3335393_c" /HighExp="BT, S8, T2.0H, LBGstat, Cold, Etha, Sw, T1.0H, T1.30H, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1251" promotor_-35 2853597..2853606 /Source="Nicolas_upshift_promotors" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2853619..2853638 /Source="Nicolas_upshift_promotors" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2853622 /Source="Nicolas_upshifts" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="upshifts" ncRNA complement(2853658..2853789) /ncRNA_class="antisense_RNA" /gene="auzJ" /locus_tag="BSU_ncRNA_2" /product="putative antisense RNA for type I YuzJ toxin" /note="Evidence 3: Putative function from multiple computational evidences" /label="auzJ ncRNA" CDS 2853658..2853789 /gene="yuzJ" /locus_tag="BSU_32469" /old_locus_tag="BSU32469" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 20525796, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative type I toxin" /protein_id="YP_003097780.1" /db_xref="EnsemblGenomes-Gn:BSU32469" /db_xref="EnsemblGenomes-Tr:CAX52686" /db_xref="GOA:C0H3Q7" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3Q7" /translation="MGFYNSGGYSGNSGYSNGFGSSFALIVVLFILLIIVGAAIFNY* " /label="yuzJ CDS" gene 2853658..2853789 /gene="yuzJ" /locus_tag="BSU_32469" /old_locus_tag="BSU32469" /label="yuzJ gene" gene complement(2853658..2853789) /gene="auzJ" /locus_tag="BSU_ncRNA_2" /label="auzJ gene" S_feature 2853790..2853858 /Source="Nicolas_S_feature" /locus_tag="new_3335546_3335614" /HighExp="BT, B36, S8, G/S, B60, Pyr, Glucon, C30, S7, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1252" downshifts 2853825 /Source="Nicolas_upshifts" /id="D1685" /incds=0 /nref=10 /ntot=25 /MaxReadThrough="0.61379" /MaxDrop="6.43101" /score="20.0549891" /energy="-14.2" /TU="NA" /idTUdmin="U2548" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2853995..2854516) /gene="pucE" /locus_tag="BSU_32470" /old_locus_tag="BSU32470" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, iron-sulfur subunit" /protein_id="NP_391127.1" /db_xref="EnsemblGenomes-Gn:BSU32470" /db_xref="EnsemblGenomes-Tr:CAB15237" /db_xref="GOA:O32143" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR002888" /db_xref="InterPro:IPR006058" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017611" /db_xref="InterPro:IPR036010" /db_xref="InterPro:IPR036884" /db_xref="SubtiList:BG13988" /db_xref="UniProtKB/Swiss-Prot:O32143" /translation="MDIKEAGPFPVKKEQFRMTVNGQAWEVAAVPTTHLSDLLRKEFQ LTGTKVSCGIGRCGACSILIDGKLANACMTMAYQADGHSITTIEGLQKEELDMCQTAF LEEGGFQCGYCTPGMIIALKALFRETPQPSDKDIEEGLAGNLCRCTGYGGIMRSACRI RRELNGGRRESGF*" /label="pucE CDS" gene complement(2853995..2854516) /gene="pucE" /locus_tag="BSU_32470" /old_locus_tag="BSU32470" /label="pucE gene" CDS complement(2854507..2856744) /gene="pucD" /locus_tag="BSU_32480" /old_locus_tag="BSU32480" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, substrate and molybdenumcofactor subunit" /protein_id="NP_391128.1" /db_xref="EnsemblGenomes-Gn:BSU32480" /db_xref="EnsemblGenomes-Tr:CAB15238" /db_xref="GOA:O32144" /db_xref="InterPro:IPR000674" /db_xref="InterPro:IPR008274" /db_xref="InterPro:IPR017609" /db_xref="InterPro:IPR036856" /db_xref="InterPro:IPR037165" /db_xref="SubtiList:BG13989" /db_xref="UniProtKB/Swiss-Prot:O32144" /translation="MIINKPSRVRPDGRGKVTGELKYMTDLSFPGMLYGKVLRSAYPH AEIVSVCTIKAEKMEGVQAVVTHKDVPGLNRFGIVIPDQPVLCEDRVRYVGDAIAAVA AETEEIAEAALELIQVEYKELEVMDSPEKALRPNAQRLHEDGNILHRAFFSNGDVEEG FQASDTVFEETYELPRQMHTYMETEGGVAVPEDDGGFTMYAGTQHGYKDRFQLARIFD IPEEKIRIVSSPMGGSFGGKDELNIQPYAALLALKSGRPVKIHQTRKESVRSGIKRHP MKITIKTGADHSGNLLAHDVKIVADTGAYATLGPAVLDFSVEHAAGPYRIPNIRTEGI SVFTNNGVAGEFRGFGGNQITFALETHLDRLSGMLGIDPLELRRKNIRKPHDLGPLEH RIAPTDGAAQVLNAISKSPILKKTSRNCGYLQRGTGAAITMHGGGLGFGRMDAAGGRL SLSSEGKITASFGFEECGQGILAAIEQIVMEELGCAAEDISIVIGDTAKVPKSGSSTA SRGTSMVWHAIQRLKKPFLAQLKKRAAEWSGCSAENLIPGAAGLRDKNTKALVVTYKE LAEKGPLAEETAFDFPTTPDPVVGGHFLYSFGAAAVEVEVDLLTGDVKLIDCEHAIAA GPVVSPQGYRGQIEGGAAMALGYTLMEEAKMTDGRYAAENLDHYLIPGIKDVPDMKLI AIEDLMKGDVYGPRGVGEIGTIAITPAIVKAVHDAVGCWINKLPISREELLEAIDRKG LKQWT*" /label="pucD CDS" gene complement(2854507..2856744) /gene="pucD" /locus_tag="BSU_32480" /old_locus_tag="BSU32480" /label="pucD gene" CDS complement(2856745..2857578) /gene="pucC" /locus_tag="BSU_32490" /old_locus_tag="BSU32490" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, FAD-binding subunit" /protein_id="NP_391129.1" /db_xref="EnsemblGenomes-Gn:BSU32490" /db_xref="EnsemblGenomes-Tr:CAB15239" /db_xref="GOA:O32145" /db_xref="InterPro:IPR002346" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR017612" /db_xref="InterPro:IPR036318" /db_xref="InterPro:IPR036683" /db_xref="SubtiList:BG13990" /db_xref="UniProtKB/Swiss-Prot:O32145" /translation="MNGQVTKARMNIQLWRPAALDEAYSLLEKLAPDVCAASGSTLLQ LQWDKGTLPKQHLVSLEGIDEMRGISTSDTHVSIGGLTSLNECRKNPLIKRALSCFSD AASAVAAPGIRSRATIGGNIASKIGDFIPLLLVLGAELIVYQKELIRLPLGAWLSEED FRTAIVTRVIIPRAEGERVFYHKLGRRQAFTGAAAVAAGRFLKDGSIRLAAGHADITP RRLLDSEAKWMAPGWDPHELYKTLIHELPFSSDVFMSAAYRKKAAANVIMAELMAEGG E*" /label="pucC CDS" gene complement(2856745..2857578) /gene="pucC" /locus_tag="BSU_32490" /old_locus_tag="BSU32490" /label="pucC gene" CDS complement(2857575..2858192) /gene="pucB" /locus_tag="BSU_32500" /old_locus_tag="BSU32500" /EC_number="2.7.7.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11344136, 21528011; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdopterin cofactor synthesis cytidylyl transferase" /protein_id="NP_391130.2" /db_xref="EnsemblGenomes-Gn:BSU32500" /db_xref="EnsemblGenomes-Tr:CAB15240" /db_xref="GOA:O32146" /db_xref="InterPro:IPR017615" /db_xref="InterPro:IPR025877" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13991" /db_xref="UniProtKB/Swiss-Prot:O32146" /translation="MRSPYLIGVFLAAGKSRRMGQNKLALPLKGENIGSLSLKTALSS RLDHVLVVERTEHASLEWIGAPYHAPPFQKRWSLHVCQDAEKGQGHSVSSGVRKAESM GADGIVILLADQPQLSVDHLNALVALAPESFAVSSFLGAFTPPIYFSSTCFPYVKGLK GDEGARRLLKSGQLGAGAVLEAKDSGELDDIDTPEEYDMVRRAMS*" /label="pucB CDS" gene complement(2857575..2858192) /gene="pucB" /locus_tag="BSU_32500" /old_locus_tag="BSU32500" /label="pucB gene" downshifts complement(2857684) /Source="Nicolas_upshifts" /id="D1686" /incds=1 /nref=3 /ntot=13 /MaxReadThrough="5.34639" /MaxDrop="3.22355" /score="-4.87239629" /energy="-9.9" /TU="U2549" /idTUdmin="U2549" /TUdmin="-3827" /isTUend="FALSE" /label="downshifts" CDS complement(2858189..2859181) /gene="pucA" /locus_tag="BSU_32510" /old_locus_tag="BSU32510" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10217763, 11344136, 12029039" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217763, 11344136, 12029039; Product type f: factor" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase molybdopterin recruitmentfactor" /protein_id="NP_391131.1" /db_xref="EnsemblGenomes-Gn:BSU32510" /db_xref="EnsemblGenomes-Tr:CAB15241" /db_xref="GOA:O32147" /db_xref="InterPro:IPR003777" /db_xref="InterPro:IPR027051" /db_xref="SubtiList:BG13992" /db_xref="UniProtKB/Swiss-Prot:O32147" /translation="MGNFHTMLDALLEDQEEAVLATIVQVEGSAYRKAGASMLFKKKG RRIGLLSGGCVEEDVFQRISALGDQLTSTLIPYDMRSEDDLSWGMGAGCNGIIHVHAE RITQEKRRHYEKVRDCLHSGKAVTSVIKIESSHYLFLTENGHFGNWPDAPLQDIQRTV STLHLPHFDQTTNMFIQRIEPKPRLILFGAGPDNVPLANLAADTGFSVIVTDWRPAYC TSSLFPKADQLITAFPEQMLSEFQFFPHDAAVVATHHYQHDQTIINFLFSQNLHYIGL LGSANRTKRLLSGKHPPSHFYSPVGLKIGAEGPEEIAVSVVAEIIQTRKRVAVV*" /label="pucA CDS" gene complement(2858189..2859181) /gene="pucA" /locus_tag="BSU_32510" /old_locus_tag="BSU32510" /label="pucA gene" S_feature complement(2859182..2859268) /Source="Nicolas_S_feature" /locus_tag="new_3340938_3341024_c" /HighExp="BT, Cold, Sw, T-1.10H, S1, C30, S0, T-0.40H, T-3.40H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.607" /TUlongSig="NA" /TUlongPSig="NA" /label="S1253" promotor_-10 complement(2859246..2859265) /Source="Nicolas_upshift_promotors" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2859268) /Source="Nicolas_upshifts" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2859279..2859284) /Source="Nicolas_upshift_promotors" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2859410..2860660) /gene="pucG" /locus_tag="BSU_32520" /old_locus_tag="BSU32520" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 20852637, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 20852637, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(S)-ureidoglycine-glyoxylate aminotransferase (PLP-dependent)" /protein_id="NP_391132.1" /db_xref="EnsemblGenomes-Gn:BSU32520" /db_xref="EnsemblGenomes-Tr:CAB15242" /db_xref="GOA:O32148" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="InterPro:IPR024169" /db_xref="PDB:3ISL" /db_xref="SubtiList:BG13993" /db_xref="UniProtKB/Swiss-Prot:O32148" /translation="MSGRRELCTPLRTIMTPGPVEVDPRVLRVMSTPVVGQFDPAFTG IMNETMEMLRELFQTKNRWAYPIDGTSRAGIEAVLASVIEPEDDVLIPIYGRFGYLLT EIAERYGANVHMLECEWGTVFDPEDIIREIKKVKPKIVAMVHGETSTGRIHPLKAIGE ACRTEDALFIVDAVATIGGCEVKVDEWKIDAAIGGTQKCLSVPSGMAPITYNERVADV IAARKKVERGIATQADRAALSGNRPITSNYFDLSQLEDYWSERRLNHHTEATTMLYAL REGVRLVLEEGLETRFERHRHHEAALAAGIKAMGLRLFGDDSCKMPVVTCVEIPGGID GESVRDMLLAQFGIEIASSFGPLAGKIWRIGTMGYSCRKENVLFVLAGLEAVLLRHNA GIEAGKALQAALDVYENAGRQAAV*" /label="pucG CDS" gene complement(2859410..2860660) /gene="pucG" /locus_tag="BSU_32520" /old_locus_tag="BSU32520" /label="pucG gene" CDS complement(2860677..2861915) /gene="pucF" /locus_tag="BSU_32530" /old_locus_tag="BSU32530" /EC_number="3.5.3.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11344136, 17362992, 25020232; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="allantoate amidohydrolase" /protein_id="NP_391133.1" /db_xref="EnsemblGenomes-Gn:BSU32530" /db_xref="EnsemblGenomes-Tr:CAB15243" /db_xref="GOA:O32149" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010158" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13994" /db_xref="UniProtKB/Swiss-Prot:O32149" /translation="MEKQKLSVKNSITDYIEWLAQYGASADGGVTRLLYTKEWMDAQL AVKTEMSSFGLETRFDDVGNVFGRLSGTQSPDEVIVTGSHIDTVINGGKYDGAYGVLA AMLALKQLKETYGAPKKTLEAVSLCEEEGSRFPMTYWGSGNMTGVFSEQDAKEPRDES GVSLQTAMHESGFGKGVFQSAYRTDISAFVELHIEQGKTLEMSGRDLGIVTSIAGQRR YLVTLEGECNHAGTTSMKWRKDPLAASSRIIHELLLRSDELPDELRLTCGKITAEPNV ANVIPGRVQFSIDIRHQHQHVLEQFHQDMVALINGICLQKGIRAVIDEYMRIEPVPMD ERLKAAAFETALENGFSCEEMVSGAGHDAQMIGRRYPACMLFVPSRGGVSHSPKEYTS ARQLEIGVRALTDLLYKLAY*" /label="pucF CDS" gene complement(2860677..2861915) /gene="pucF" /locus_tag="BSU_32530" /old_locus_tag="BSU32530" /label="pucF gene" CDS 2862138..2862275 /locus_tag="BSU_32539" /old_locus_tag="BSU32539" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514002.1" /translation="MNKLSWRGDVRGTDENRNAGSPQKQDLKIWKQEISASSKGTNLQ F*" /label="hypothetical protein CDS" gene 2862138..2862275 /locus_tag="BSU_32539" /old_locus_tag="BSU32539" /label="gene" promotor_-35 2862297..2862300 /Source="Nicolas_upshift_promotors" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2862315..2862334 /Source="Nicolas_upshift_promotors" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2862316 /Source="Nicolas_upshifts" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="upshifts" CDS 2862357..2863223 /gene="bsnA" /locus_tag="BSU_32540" /old_locus_tag="BSU32540" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1396690, 12490701, 12883447, 16291680, 25844442" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1396690, 12490701, 12883447, 16291680, 25844442; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular ribonuclease" /protein_id="NP_391134.1" /db_xref="EnsemblGenomes-Gn:BSU32540" /db_xref="EnsemblGenomes-Tr:CAB15244" /db_xref="GOA:O32150" /db_xref="InterPro:IPR007346" /db_xref="SubtiList:BG13995" /db_xref="UniProtKB/Swiss-Prot:O32150" /translation="MTKKAWFLPLVCVLLISGWLAPAASASAQTTLSLNDRLASSPSG TGSLLSLAAPAAPYADTDTYYEGAEGKTGDSLKSTLHRIISGHTMLSYSEVWNALKET DEDPRNPNNVILLYTNESRSKNLNGGNVGDWNREHVWAKSHGDFGTSKGPGTDIHHLR PADVQVNSARGNMDFDNGGTEYAKAPGNYYDGDSWEPRDDVKGDVARMLFYMAVRYEG DDGYPDLELNDKTGNGSAPYHGKQSVLLEWNKQDPVDDRERKRNEIIYEKYQHNRNPF IDHPEWADEIWP*" /label="bsnA CDS" gene 2862357..2863223 /gene="bsnA" /locus_tag="BSU_32540" /old_locus_tag="BSU32540" /label="bsnA gene" downshifts 2863226 /Source="Nicolas_upshifts" /id="D1687" /incds=0 /nref=48 /ntot=190 /MaxReadThrough="0.45317" /MaxDrop="6.90997" /score="25.7790712" /energy="-15.5" /TU="NA" /idTUdmin="U2550" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(2863257..2864360) /gene="frlP" /locus_tag="BSU_32550" /old_locus_tag="BSU32550" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23175651, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23175651, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid ABC transporter (ATP-bindingsubunit)" /protein_id="NP_391135.1" /db_xref="EnsemblGenomes-Gn:BSU32550" /db_xref="EnsemblGenomes-Tr:CAB15245" /db_xref="GOA:O32151" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008995" /db_xref="InterPro:IPR013611" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13996" /db_xref="UniProtKB/Swiss-Prot:O32151" /translation="MASLTFEHVKKSYHSQLTVKDFDLDVKDKELLVLVGPSGCGKST TLRMVAGLESISEGNLLIDGERVNDLPPKERDIAMVFQNYALYPHMTVFDNMAFGLKL RKMAKQEIAERVHAAARILEIEHLLKRKPKALSGGQRQRVALGRSIVREPKVFLMDEP LSNLDAKLRVTMRTEISKLHQRLEATIIYVTHDQTEAMTMGDRIVVMNEGEIQQVAKP HDIYHYPANLFVAGFIGSPGMNFLKGIIEQQHGELFFTNSSIRLHIPEEKAKRLKEKG YAGEQMIAGVRPEHITQMTGNDQLFDSVFQANVEVNENLGSELIVHVMAGDERLKVRL DGNTRIDAGDSIQLSVKMDHVVFFDAETEEAVY*" /label="frlP CDS" gene complement(2863257..2864360) /gene="frlP" /locus_tag="BSU_32550" /old_locus_tag="BSU32550" /label="frlP gene" downshifts complement(2863272) /Source="Nicolas_upshifts" /id="D1688" /incds=0 /nref=57 /ntot=215 /MaxReadThrough="3.04361" /MaxDrop="6.06171" /score="29.1144499" /energy="-15.5" /TU="NA" /idTUdmin="U2553" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2864361..2865294) /Source="Nicolas_S_feature" /locus_tag="new_3346117_3347050_c" /HighExp="HiOs, T-5.40H, T5.0H, GM-0.1, S2, GM-0.2, GM 5, T-4.40H, T4.0H, SMM" /AntisenseName="frlR" /AntisenseCor="0.22682293682100099" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.971, 0.456, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1254" promotor_-35 2864398..2864405 /Source="Nicolas_upshift_promotors" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2864419..2864438 /Source="Nicolas_upshift_promotors" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2864429 /Source="Nicolas_upshifts" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2864480..2864486 /Source="Nicolas_upshift_promotors" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2864497 /Source="Nicolas_upshifts" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2864501..2864520 /Source="Nicolas_upshift_promotors" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2864542..2865270 /gene="frlR" /locus_tag="BSU_32560" /old_locus_tag="BSU32560" /experiment="publication(s) with functional evidences, PMID:21347729, 21398478, 24673833" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21347729, 21398478, 24673833; Product type r: regulator" /codon_start=1 /transl_table=11 /product="FrlR transcriptional regulator (GntR family)" /protein_id="NP_391136.3" /db_xref="EnsemblGenomes-Gn:BSU32560" /db_xref="EnsemblGenomes-Tr:CAB15246" /db_xref="GOA:O32152" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2IKK" /db_xref="SubtiList:BG13997" /db_xref="UniProtKB/Swiss-Prot:O32152" /translation="MLNNGSSTPLYIQLKQIITDDIKKGVYSPTAKLPTENELCTKYN VSRITVRKAILDLVEEGYLIRQQGKGTFVKSPKLKRELIAVNGYSEFMESTGKKPKHH VLSHDIIPASKPIAEKLQIQPESPVVELKRILYNDDQPLTFEVTHYPLDLFPGIDTFI ADGVSMHDILKQQYKVVPTHNTKLLNVVYAQQEESKYLDCDIGDALFEIDKTAFTSND QPIYCSLFLMHTNRVTFTINSPYT*" /label="frlR CDS" gene 2864542..2865270 /gene="frlR" /locus_tag="BSU_32560" /old_locus_tag="BSU32560" /label="frlR gene" CDS complement(2865295..2866149) /gene="frlD" /locus_tag="BSU_32570" /old_locus_tag="BSU32570" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 14641112, 15556630, 16153181, 21347729, 21398478, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="fructoselysine kinase" /protein_id="NP_391137.1" /db_xref="EnsemblGenomes-Gn:BSU32570" /db_xref="EnsemblGenomes-Tr:CAB15247" /db_xref="GOA:O32153" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG13998" /db_xref="UniProtKB/Swiss-Prot:O32153" /translation="MKLIAVGDNVVDYYQDQETFYPGGNALNVAVLAKRLGHESSYIG IVGNDEAAAHLLNVLKLEQVNADYIRQAHGENGMAIVTLDEQGDRIFVRSNKGGIQSR LRLAFQEKDVSFISGHDLLHTSVYSRLENDLPQLCGLVPVSFDFSTNREDDYLRRVCP YVTYAFFSGSDLSESECGELAKTAHGYGAKMVCMTRGGQGAILSAGDRVYHQPIVEAD IIDTLGAGDSFIAGFLTAFCVKQDITYALRQAAETAAKTCGVYGAFGYGYPYRLEDGG SSEKTRIL*" /label="frlD CDS" gene complement(2865295..2866149) /gene="frlD" /locus_tag="BSU_32570" /old_locus_tag="BSU32570" /label="frlD gene" misc_feature complement(2865482..2865501) /Source="Nicolas_upshift_promotors" /id="U2553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.77022977022977" /psig="0.971028971028971" /xcortree=571 /SigmaFactorBS="aaggagcaatcctgtctgcgggtgatcgagtctatcatcagc cgattgtggaaGCTGATATAATAGATACACTtggagcgggagattcttttatagcagg c" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2865494) /Source="Nicolas_upshifts" /id="U2553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.77022977022977" /psig="0.971028971028971" /xcortree=571 /SigmaFactorBS="aaggagcaatcctgtctgcgggtgatcgagtctatcatcagc cgattgtggaaGCTGATATAATAGATACACTtggagcgggagattcttttatagcagg c" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box complement(2865652..2865752) /Source="Nicolas_upshift_promotors" /id="U2554" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.320679320679321" /psig="0.455544455544456" /xcortree=1631 /SigmaFactorBS="ttccgcagctgtgcgggctggtcccggtctcatttgattttt caaccaatcgggaggatgattatttgaggagggtctgtccttatgtgacgtatgcgtt t" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2865692) /Source="Nicolas_upshifts" /id="U2554" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.320679320679321" /psig="0.455544455544456" /xcortree=1631 /SigmaFactorBS="ttccgcagctgtgcgggctggtcccggtctcatttgattttt caaccaatcgggaggatgattatttgaggagggtctgtccttatgtgacgtatgcgtt t" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2866163..2867065) /gene="frlM" /locus_tag="BSU_32580" /old_locus_tag="BSU32580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 15849754, 16850406, 15556630, 21347729; Product type t : transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid permease" /protein_id="NP_391138.1" /db_xref="EnsemblGenomes-Gn:BSU32580" /db_xref="EnsemblGenomes-Tr:CAB15248" /db_xref="GOA:O32154" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13999" /db_xref="UniProtKB/Swiss-Prot:O32154" /translation="MLPQKKTDSFRLEPVPDQHIEVKDKPRRKWYIGETSVWVFLFLY LIAIAYPLLWMVMSAFKNSDDIFEHSWSLPSSWHPENFVSAWNQGISSYFMNSVIVTA LTCVITVFISAWAAYGLSRFEFKGKGFFLVLCLGGLMLTPQVSLVPLYSIIQSLGLYN TYWALILPYAAYRIPFTIILIRSYFLSISKELEEAAYLDGCTSFGVFFRIFLPMSVPI LVTSGILTAYHTWNEFMFAIIFIDDENLRTIPAGLMQFRDALQTDWGVLLAGLTISAA PIIILFLLMQKYFVRGIASGSVKG*" /label="frlM CDS" gene complement(2866163..2867065) /gene="frlM" /locus_tag="BSU_32580" /old_locus_tag="BSU32580" /label="frlM gene" CDS complement(2867069..2867947) /gene="frlN" /locus_tag="BSU_32590" /old_locus_tag="BSU32590" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 15849754, 16850406, 15556630, 21347729; Product type t : transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid permease" /protein_id="NP_391139.1" /db_xref="EnsemblGenomes-Gn:BSU32590" /db_xref="EnsemblGenomes-Tr:CAB15249" /db_xref="GOA:O32155" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14000" /db_xref="UniProtKB/Swiss-Prot:O32155" /translation="MVNQNKIIPYLFLVPALVFLLFVYIPIFENVFLSLFQWSSFSPE KTFIGLKNYVELFHDPVFYQALTNNVLYAVISIVCQVFGGLILAAVLEDKLVRKWSPF FRTVFFLPVVISMTVIALLFDFIYNPETGLLNQLLQAIGLDQLTRAWLGDDSTAMLSV IFVSQWQSVGYIAMLYIVSIQKIPDELYEAARLDGAGKIQQFFHITVPQTKEMSFVAV VMTLTGAFTVFNEPYILTGGGPGKASEVLSTFLYKSAFTKDMMGYASAIATVVLIITL ALSLMQMKFFKTGKEE*" /label="frlN CDS" gene complement(2867069..2867947) /gene="frlN" /locus_tag="BSU_32590" /old_locus_tag="BSU32590" /label="frlN gene" CDS complement(2868005..2869273) /gene="frlO" /locus_tag="BSU_32600" /old_locus_tag="BSU32600" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 21347729; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fructose amino acid-binding lipoprotein" /protein_id="NP_391140.1" /db_xref="EnsemblGenomes-Gn:BSU32600" /db_xref="EnsemblGenomes-Tr:CAB15250" /db_xref="GOA:O32156" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG14001" /db_xref="UniProtKB/Swiss-Prot:O32156" /translation="MKKMLLFLIIAAVSMLTIAGCSSQSSSADGKVTLKFFHRWPKEP EKSYFEEVVKEFEKDHPDIDIQIEAVLNDSYKDKIKVMLGTTSPPDIYFSWSDEFAFK FIRGNKALDLSSYYKNDTDWSSQLVQSQITPFTYENKQYGVPWQMDAKSFFYNKDIFQ KLNLDPPKTWDELIDVSKKLKEHGYTPISFGTKATWTISHYIGTLNQRMVDEKTREKD YNAKTGEFTDEGYVKALEKLQELMPYFNKHVNSVDHEYVRQQFKSGKSAMIYAETAEI KLVEPVNLGMFPFPEISGQKGSSEALTGAPEGFMISSRTKHPKEAMEFLQFLTSKRMG EKLVKDVGKYSAVQGTATEENATAIQREAVQHIVDAKSMVPWFDMDVDVEVADAYLTG VQQMLGGDMTPQQVMKAVQKAAKQVRASAE*" /label="frlO CDS" gene complement(2868005..2869273) /gene="frlO" /locus_tag="BSU_32600" /old_locus_tag="BSU32600" /label="frlO gene" promotor_no_box 2869164..2869264 /Source="Nicolas_upshift_promotors" /id="U2555" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.000999000999001" /xcortree=21 /SigmaFactorBS="aaaaatttcaatgtcacctttccgtccgctgaactgctttgg ctcgaacagcctgcgatggtgagcatactgacagctgcaatgatcaagaacaacaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2869224 /Source="Nicolas_upshifts" /id="U2555" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.000999000999001" /xcortree=21 /SigmaFactorBS="aaaaatttcaatgtcacctttccgtccgctgaactgctttgg ctcgaacagcctgcgatggtgagcatactgacagctgcaatgatcaagaacaacaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2869344) /Source="Nicolas_upshifts" /id="D1689" /incds=0 /nref=21 /ntot=141 /MaxReadThrough="7.96763" /MaxDrop="4.994" /score="3.53212058" /energy="-13.8" /TU="U2557" /idTUdmin="U2558" /TUdmin=1210 /isTUend="FALSE" /label="downshifts" CDS complement(2869354..2870340) /gene="frlB" /locus_tag="BSU_32610" /old_locus_tag="BSU32610" /EC_number="3.5.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 12618455, 15556630, 16153181, 18083814, 21347729, 21398478, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructosamine-6-P deglycase" /protein_id="NP_391141.1" /db_xref="EnsemblGenomes-Gn:BSU32610" /db_xref="EnsemblGenomes-Tr:CAB15251" /db_xref="GOA:O32157" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR024713" /db_xref="InterPro:IPR035488" /db_xref="InterPro:IPR035490" /db_xref="PDB:3EUA" /db_xref="SubtiList:BG14002" /db_xref="UniProtKB/Swiss-Prot:O32157" /translation="MSQATAKVNREVQAFLQDLKGKTIDHVFFVACGGSSAIMYPSKY VFDRESKSINSDLYSANEFIQRNPVQLGEKSLVILCSHSGNTPETVKAAAFARGKGAL TIAMTFKPESPLAQEAQYVAQYDWGDEALAINTNYGVLYQIVFGTLQVLENNTKFEQA IEGLDQLQAVYEKALKQEADNAKQFAKAHEKESIIYTMASGANYGVAYSYSICILMEM QWIHSHAIHAGEYFHGPFEIIDESVPFIILLGLDETRPLEERALTFSKKYGKKLTVLD AASYDFTAIDDSVKGYLAPLVLNRVLRSYADELAEERNHPLSHRRYMWKVEY*" /label="frlB CDS" gene complement(2869354..2870340) /gene="frlB" /locus_tag="BSU_32610" /old_locus_tag="BSU32610" /label="frlB gene" upshifts 2870287 /Source="Nicolas_upshifts" /id="U2556" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.002997002997003" /xcortree=22 /SigmaFactorBS="aatggcagaagaccctccgcatgcgacaaagaatacatgatc aatggttttccctttcaaatcCTGCAagaaagcttgaacctcacgatttacttttgct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2870290..2870294 /Source="Nicolas_upshift_promotors" /id="U2556" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.002997002997003" /xcortree=22 /SigmaFactorBS="aatggcagaagaccctccgcatgcgacaaagaatacatgatc aatggttttccctttcaaatcCTGCAagaaagcttgaacctcacgatttacttttgct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2870383..2870402) /Source="Nicolas_upshift_promotors" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2870396) /Source="Nicolas_upshifts" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2870417..2870424) /Source="Nicolas_upshift_promotors" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2870554) /Source="Nicolas_upshifts" /id="D1690" /incds=0 /nref=116 /ntot=274 /MaxReadThrough="0.87627" /MaxDrop="5.35981" /score="3.53212058" /energy="-13.8" /TU="NA" /idTUdmin="U2558" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2870556..2870930) /gene="yurQ" /locus_tag="BSU_32620" /old_locus_tag="BSU32620" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative excinuclease" /protein_id="NP_391142.1" /db_xref="EnsemblGenomes-Gn:BSU32620" /db_xref="EnsemblGenomes-Tr:CAB15252" /db_xref="GOA:O32158" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR014527" /db_xref="InterPro:IPR035901" /db_xref="SubtiList:BG14003" /db_xref="UniProtKB/Swiss-Prot:O32158" /translation="MIKIDIPAPNVTITERQQSANDNEPKIKPIHGFIDFHQIPRDKG GIFMFYNIHDELLFVGKARKLRQRIKKHFEDTVSPIKHHRDEVYKIEVCVVDDPMERE IYETYIINTQHSKYNIDKVFFK*" /label="yurQ CDS" gene complement(2870556..2870930) /gene="yurQ" /locus_tag="BSU_32620" /old_locus_tag="BSU32620" /label="yurQ gene" upshifts complement(2870994) /Source="Nicolas_upshifts" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2871001..2871012) /Source="Nicolas_upshift_promotors" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2871026..2871032) /Source="Nicolas_upshift_promotors" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2871033..2872151) /gene="dadA" /locus_tag="BSU_32630" /old_locus_tag="BSU32630" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 13914427, 16245349, 22271930, 24826896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-amino acid oxidase" /protein_id="NP_391143.1" /db_xref="EnsemblGenomes-Gn:BSU32630" /db_xref="EnsemblGenomes-Tr:CAB15253" /db_xref="GOA:O32159" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG14004" /db_xref="UniProtKB/Swiss-Prot:O32159" /translation="MKSYIIVGAGILGASTAYHLAKTGARVTVIDRKEPGQATDAAAG IVCPWLSQRRNQDWYQLAKGGARYYKDLIHQLEKDGESDTGYKRVGAISIHTDASKLD KMEERAYKRREDAPEIGDITRLSASETKKLFPILADGYESVHISGAARVNGRALCRSL LSAAEKRGATVIKGNASLLFENGTVTGVQTDTKQFAADAVIVTAGAWANEILKPLGIH FQVSFQKAQIMHFEMTDADTGSWPVVMPPSDQYILSFDNGRIVAGATHENDAGLDDLR VTAGGQHEVLSKALAVAPGLADAAAVETRVGFRPFTPGFLPVVGAVPNVQGLYAANGL GASGLTMGPFLGAELAKLVLGKQTELDLSPYDPAGALA*" /label="dadA CDS" gene complement(2871033..2872151) /gene="dadA" /locus_tag="BSU_32630" /old_locus_tag="BSU32630" /label="dadA gene" promotor_-10 complement(2872176..2872195) /Source="Nicolas_upshift_promotors" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2872182) /Source="Nicolas_upshifts" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2872184..2872794) /Source="Nicolas_S_feature" /locus_tag="new_3353940_3354550_c" /HighExp="G135, H2O2, G180, Paraq, G150, Oxctl, LBGexp, Salt, dia15, Diami" /AntisenseName="yurS" /AntisenseCor="-0.14245591415946501" /AntisenseRegPval="-1.7" /CDS_PredictionProba="0.95340499999999995" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1255" promotor_-35 complement(2872209..2872215) /Source="Nicolas_upshift_promotors" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2872248..2872257 /Source="Nicolas_upshift_promotors" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2872271..2872290 /Source="Nicolas_upshift_promotors" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2872275 /Source="Nicolas_upshifts" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2872288..2872303) /Source="Nicolas_upshift_promotors" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2872292) /Source="Nicolas_upshifts" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2872310..2872314) /Source="Nicolas_upshift_promotors" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2872310..2872456 /gene="sspG" /locus_tag="BSU_32640" /old_locus_tag="BSU32640" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018; Product type f : factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054592.1" /db_xref="EnsemblGenomes-Gn:BSU32640" /db_xref="EnsemblGenomes-Tr:CAE01466" /db_xref="GOA:Q7WY59" /db_xref="SubtiList:BG14173" /db_xref="UniProtKB/Swiss-Prot:Q7WY59" /translation="MSENRHENEENRRDAAVAKVQNSGNAKVVVSVNTDQDQAQAQSQ DGED*" /label="sspG CDS" gene 2872310..2872456 /gene="sspG" /locus_tag="BSU_32640" /old_locus_tag="BSU32640" /label="sspG gene" CDS 2872456..2872731 /gene="yurS" /locus_tag="BSU_32650" /old_locus_tag="BSU32650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 9852018" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391144.1" /db_xref="EnsemblGenomes-Gn:BSU32650" /db_xref="EnsemblGenomes-Tr:CAB15254" /db_xref="SubtiList:BG14005" /db_xref="UniProtKB/Swiss-Prot:O32160" /translation="MNENIIPLNRHTQEIPTTESVIKNSGNSEVHIDIHIDTMPIAFA ILCSALAAKQMTKEEFDMAYTQLREMNRENNSRSSVKQIINQETEEE*" /label="yurS CDS" gene 2872456..2872731 /gene="yurS" /locus_tag="BSU_32650" /old_locus_tag="BSU32650" /label="yurS gene" upshifts complement(2872600) /Source="Nicolas_upshifts" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2872616..2872630) /Source="Nicolas_upshift_promotors" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2872639..2872643) /Source="Nicolas_upshift_promotors" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2872711 /Source="Nicolas_upshifts" /id="D1691" /incds=0 /nref=36 /ntot=86 /MaxReadThrough="1.84089" /MaxDrop="7.4989" /score="15.0184762" /energy="-11" /TU="NA" /idTUdmin="U2560" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(2872795..2873178) /gene="glxB" /locus_tag="BSU_32660" /old_locus_tag="BSU32660" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10882093, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10882093, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglyoxalase; lactoylbacillithiol lyase" /protein_id="NP_391145.1" /db_xref="EnsemblGenomes-Gn:BSU32660" /db_xref="EnsemblGenomes-Tr:CAB15255" /db_xref="GOA:O32161" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG14006" /db_xref="UniProtKB/Swiss-Prot:O32161" /translation="MKIVVTSIFVQDQDMALEFYTEKLGFIKKEDVPMGKFRWITLVS PDDQDGTELLLEPNEHPAAKEYQKKIFSEGLPATMFGVADIQKEYNRLKEKGVTFTTE PTKMGEVTIAVFDDTCGNLIQIVQK*" /label="glxB CDS" gene complement(2872795..2873178) /gene="glxB" /locus_tag="BSU_32660" /old_locus_tag="BSU32660" /label="glxB gene" S_feature complement(2873179..2873288) /Source="Nicolas_S_feature" /locus_tag="new_3354935_3355044_c" /HighExp="Salt, G180, H2O2, Paraq, G135, G150, LBGexp, LBGstat, dia15, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1256" CDS complement(2873289..2873567) /gene="yuzN" /locus_tag="BSU_32669" /old_locus_tag="BSU32669" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="YP_003097781.1" /db_xref="EnsemblGenomes-Gn:BSU32669" /db_xref="EnsemblGenomes-Tr:CAX52687" /db_xref="GOA:C0H3Q8" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3Q8" /translation="MNGNKDAIFKALGDSTRRLILDELSERNELTLYELTIRLITKYD LSITRQAIAKHLSVLEDAGLVTSKRKGKYRVLIFNNEPLKNLLKGWIE*" /label="yuzN CDS" gene complement(2873289..2873567) /gene="yuzN" /locus_tag="BSU_32669" /old_locus_tag="BSU32669" /label="yuzN gene" promotor_-10 complement(2873565..2873584) /Source="Nicolas_upshift_promotors" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2873589) /Source="Nicolas_upshifts" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2873599..2873606) /Source="Nicolas_upshift_promotors" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2873730..2873836) /Source="Nicolas_S_feature" /locus_tag="new_3355486_3355592_c" /HighExp="Sw, BI, LPhT, C90, BC, M0t45, Gly, Cold, H2O2, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.994" /TUlongSig="SigGF" /TUlongPSig="0.999" /label="S1257" downshifts complement(2873773) /Source="Nicolas_upshifts" /id="D1692" /incds=0 /nref=189 /ntot=303 /MaxReadThrough="3.22318" /MaxDrop="7.82118" /score="0.760415296" /energy="-10.1" /TU="U2564" /idTUdmin="U2565" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2873837..2875234) /gene="sufB" /locus_tag="BSU_32670" /old_locus_tag="BSU32670" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16109955, 16431905, 16621837, 20097860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16109955, 16431905, 16621837, 20097860; Product type f: factor" /codon_start=1 /transl_table=11 /product="FeS cluster formation scaffold protein" /protein_id="NP_391146.1" /db_xref="EnsemblGenomes-Gn:BSU32670" /db_xref="EnsemblGenomes-Tr:CAB15256" /db_xref="GOA:O32162" /db_xref="InterPro:IPR000825" /db_xref="InterPro:IPR010231" /db_xref="SubtiList:BG14007" /db_xref="UniProtKB/Swiss-Prot:O32162" /translation="MAKKMPDIGEYKYGFHDKDVSIFRSERGLTKEIVEEISRMKEEP QWMLDFRLKSLEHFYNMPMPQWGGDLNSLNFDEITYYVKPSERSERSWDEVPEEIKQT FDKLGIPEAEQKYLAGVSAQYESEVVYHNMKEDLEAQGIVFKDTDSALKENEDIFREH WAKVIPPTDNKFAALNSAVWSGGSFIYVPKGVKVETPLQAYFRINSENMGQFERTLII VDEEASVHYVEGCTAPVYTTNSLHSAVVEIIVKKGGYCRYTTIQNWANNVYNLVTKRT VCEENATMEWIDGNIGSKLTMKYPACILKGEGARGMTLSIALAGKGQHQDAGAKMIHL APNTSSTIVSKSISKQGGKVTYRGIVHFGRKAEGARSNIECDTLIMDNKSTSDTIPYN EILNDNISLEHEAKVSKVSEEQLFYLMSRGISEEEATEMIVMGFIEPFTKELPMEYAV EMNRLIKFEMEGSIG*" /label="sufB CDS" gene complement(2873837..2875234) /gene="sufB" /locus_tag="BSU_32670" /old_locus_tag="BSU32670" /label="sufB gene" downshifts 2875032 /Source="Nicolas_upshifts" /id="D1693" /incds=1 /nref=1 /ntot=150 /MaxReadThrough="2.66718" /MaxDrop="3.75483" /score="-4.89805724" /energy="-5" /TU="NA" /idTUdmin="U2560" /TUdmin=2310 /isTUend="FALSE" /label="downshifts" CDS complement(2875255..2875698) /gene="sufU" /locus_tag="BSU_32680" /old_locus_tag="BSU32680" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16877383, 20097860, 21236255, 24321018, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16877383, 20097860, 21236255, 24321018, 22720735; Product type f : factor" /codon_start=1 /transl_table=11 /product="iron-sulfur cluster assembly sulfur-transfer protein (Zn(2+)-dependent)" /protein_id="NP_391147.1" /db_xref="EnsemblGenomes-Gn:BSU32680" /db_xref="EnsemblGenomes-Tr:CAB15257" /db_xref="GOA:O32163" /db_xref="InterPro:IPR002871" /db_xref="PDB:1XJS" /db_xref="PDB:2AZH" /db_xref="SubtiList:BG14008" /db_xref="UniProtKB/Swiss-Prot:O32163" /translation="MSFNANLDTLYRQVIMDHYKNPRNKGVLNDSIVVDMNNPTCGDR IRLTMKLDGDIVEDAKFEGEGCSISMASASMMTQAIKGKDIETALSMSKIFSDMMQGK EYDDSIDLGDIEALQGVSKFPARIKCATLSWKALEKGVAKEEGGN*" /label="sufU CDS" gene complement(2875255..2875698) /gene="sufU" /locus_tag="BSU_32680" /old_locus_tag="BSU32680" /label="sufU gene" CDS complement(2875688..2876908) /gene="sufS" /locus_tag="BSU_32690" /old_locus_tag="BSU32690" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 12876288, 14644425, 15901727, 20822158, 21236255, 27382962" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12876288, 14644425, 15901727, 20822158, 21236255, 27382962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase" /protein_id="NP_391148.1" /db_xref="EnsemblGenomes-Gn:BSU32690" /db_xref="EnsemblGenomes-Tr:CAB15258" /db_xref="GOA:O32164" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR010970" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="PDB:5J8Q" /db_xref="SubtiList:BG14009" /db_xref="UniProtKB/Swiss-Prot:O32164" /translation="MNITDIREQFPILHQQVNGHDLVYLDSAATSQKPRAVIETLDKY YNQYNSNVHRGVHTLGTRATDGYEGAREKVRKFINAKSMAEIIFTKGTTTSLNMVALS YARANLKPGDEVVITYMEHHANIIPWQQAVKATGATLKYIPLQEDGTISLEDVRETVT SNTKIVAVSHVSNVLGTVNPIKEMAKIAHDNGAVIVVDGAQSTPHMKIDVQDLDCDFF ALSSHKMCGPTGVGVLYGKKALLENMEPAEFGGEMIDFVGLYESTWKELPWKFEAGTP IIAGAIGLGAAIDFLEEIGLDEISRHEHKLAAYALERFRQLDGVTVYGPEERAGLVTF NLDDVHPHDVATVLDAEGIAVRAGHHCAQPLMKWLDVTATARASFYLYNTEEEIDKLV EALQKTKEYFTNVF*" /label="sufS CDS" gene complement(2875688..2876908) /gene="sufS" /locus_tag="BSU_32690" /old_locus_tag="BSU32690" /label="sufS gene" CDS complement(2876908..2878221) /gene="sufD" /locus_tag="BSU_32700" /old_locus_tag="BSU32700" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16109955, 16431905, 16621837, 19187533, 20097860, 28839209; Product type f: factor" /codon_start=1 /transl_table=11 /product="Fe-S cluster assembly protein SufD" /protein_id="NP_391149.1" /db_xref="EnsemblGenomes-Gn:BSU32700" /db_xref="EnsemblGenomes-Tr:CAB15259" /db_xref="GOA:O32165" /db_xref="InterPro:IPR000825" /db_xref="InterPro:IPR011542" /db_xref="SubtiList:BG14010" /db_xref="UniProtKB/Swiss-Prot:O32165" /translation="MTLGTKLSVDQEYLKSFSEKHQEPAWLKNLRLQALEQAEDLPMP KPDKTKITNWNFTNFAKHTVDNEPLSSLEDLTDEVKALIDIENEDKTLYVQRDQTPAH LSLSQELKDKGVIFTDILTAAREHSDLVEKYFMKDGVKVDEHKLTALHAALVNGGAFL YVPKNVQVETPVQAVYVHESNDTALFNHVLIVAEDHSSVTYVENYISTVNPKDAVFNI ISEVITGDNASVTYGAVDNLSSGVTTYVNRRGAARGRDSKIEWALGLMNDGDTISENT TNLYGDGTYGDTKTVVVGRGEQTENFTTQIIHFGKASEGYILKHGVMKDSASSIFNGI GKIEHGASKANAEQESRVLMLSEKARGDANPILLIDEDDVTAGHAASVGRVDPIQLYY LMSRGIPKEEAERLVIYGFLAPVVNELPIEGVKKQLVSVIERKVK*" /label="sufD CDS" gene complement(2876908..2878221) /gene="sufD" /locus_tag="BSU_32700" /old_locus_tag="BSU32700" /label="sufD gene" CDS complement(2878239..2879024) /gene="sufC" /locus_tag="BSU_32710" /old_locus_tag="BSU32710" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16431905, 20097860, 28839209" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16431905, 20097860, 28839209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sulfur mobilizing ABC protein, ATPase" /protein_id="NP_391150.1" /db_xref="EnsemblGenomes-Gn:BSU32710" /db_xref="EnsemblGenomes-Tr:CAB15260" /db_xref="GOA:P80866" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR010230" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14011" /db_xref="UniProtKB/Swiss-Prot:P80866" /translation="MAASTLTIKDLHVEIEGKEILKGVNLEIKGGEFHAVMGPNGTGK STLSAAIMGHPKYEVTKGSITLDGKDVLEMEVDERAQAGLFLAMQYPSEISGVTNADF LRSAINARREEGDEISLMKFIRKMDENMEFLEMDPEMAQRYLNEGFSGGEKKRNEILQ LMMIEPKIAILDEIDSGLDIDALKVVSKGINKMRSENFGCLMITHYQRLLNYITPDVV HVMMQGRVVKSGGAELAQRLEAEGYDWIKQELGIEDETVGQEA*" /label="sufC CDS" gene complement(2878239..2879024) /gene="sufC" /locus_tag="BSU_32710" /old_locus_tag="BSU32710" /label="sufC gene" promotor_-10 complement(2879068..2879087) /Source="Nicolas_upshift_promotors" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-10" upshifts complement(2879069) /Source="Nicolas_upshifts" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="upshifts" promotor_-35 complement(2879101..2879108) /Source="Nicolas_upshift_promotors" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-35" promotor_-10 complement(2879125..2879144) /Source="Nicolas_upshift_promotors" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-10" upshifts complement(2879134) /Source="Nicolas_upshifts" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="upshifts" S_feature complement(2879136..2879217) /Source="Nicolas_S_feature" /locus_tag="new_3360892_3360973_c" /HighExp="Salt, HiOs, B60, LoTm, T1.0H, Gly, T2.0H, C30, Etha, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.994, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1258" promotor_-35 complement(2879160..2879164) /Source="Nicolas_upshift_promotors" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-35" misc_RNA complement(2879181..2879428) /gene="bsrI" /locus_tag="BSU_misc_RNA_84" /product="small regulatory RNA or messenger RNA" /experiment="publication(s) with functional evidences, PMID:18948176" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176; Product type n: RNA" /label="bsrI RNA" gene complement(2879181..2879428) /gene="bsrI" /locus_tag="BSU_misc_RNA_84" /label="bsrI gene" CDS complement(2879218..2879355) /gene="yuzK" /locus_tag="BSU_32719" /old_locus_tag="BSU32719" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a toxin antitoxin system" /protein_id="YP_003097782.1" /db_xref="EnsemblGenomes-Gn:BSU32719" /db_xref="EnsemblGenomes-Tr:CAX52688" /db_xref="UniProtKB/Swiss-Prot:C0H3Q9" /translation="MEKAMQLSHGIGYEEYGRRLETRMKVERQRELDYEKSKRISAGA Y*" /label="yuzK CDS" gene complement(2879218..2879355) /gene="yuzK" /locus_tag="BSU_32719" /old_locus_tag="BSU32719" /label="yuzK gene" S_feature complement(2879356..2879440) /Source="Nicolas_S_feature" /locus_tag="new_3361112_3361196_c" /HighExp="HiOs, Salt, B60, S5, T1.0H, S8, HiTm, S7, T1.30H, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.63415999999999995" /TUshortSig="SigA, SigGF" /TUshortPSig="0.994, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1259" promotor_-10 complement(2879424..2879443) /Source="Nicolas_upshift_promotors" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2879440) /Source="Nicolas_upshifts" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2879442..2879548) /Source="Nicolas_S_feature" /locus_tag="new_3361198_3361304_c" /HighExp="S8, S5, S7, S6, S4, BT, ferm, nit, S3, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1260" promotor_-35 complement(2879459..2879462) /Source="Nicolas_upshift_promotors" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2879549..2879926) /gene="yurZ" /locus_tag="BSU_32720" /old_locus_tag="BSU32720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391151.1" /db_xref="EnsemblGenomes-Gn:BSU32720" /db_xref="EnsemblGenomes-Tr:CAB15261" /db_xref="GOA:O32166" /db_xref="InterPro:IPR003779" /db_xref="InterPro:IPR029032" /db_xref="SubtiList:BG14012" /db_xref="UniProtKB/Swiss-Prot:O32166" /translation="MEGFSLNQDRGSMQDALKQYKHGLGTFEQKMPLMGRKFNEFTEQ CFAGNSLTEREKQLIALGIAINAQDEYCMIYHTKGCLDQGASEENILEAVSVAAAFGG GAAFSQGVTVVQQCIEEFGNTTH*" /label="yurZ CDS" gene complement(2879549..2879926) /gene="yurZ" /locus_tag="BSU_32720" /old_locus_tag="BSU32720" /label="yurZ gene" promotor_-10 complement(2879943..2879954) /Source="Nicolas_upshift_promotors" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="promotor_-10" upshifts complement(2879949) /Source="Nicolas_upshifts" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="upshifts" promotor_-35 complement(2879968..2879974) /Source="Nicolas_upshift_promotors" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="promotor_-35" CDS complement(2880011..2880835) /gene="metQ" /locus_tag="BSU_32730" /old_locus_tag="BSU32730" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 16109943, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 16109943, 17038623; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter, substrate binding lipoprotein" /protein_id="NP_391152.1" /db_xref="EnsemblGenomes-Gn:BSU32730" /db_xref="EnsemblGenomes-Tr:CAB15262" /db_xref="GOA:O32167" /db_xref="InterPro:IPR004872" /db_xref="PDB:4GOT" /db_xref="SubtiList:BG14013" /db_xref="UniProtKB/Swiss-Prot:O32167" /translation="MKKLFLGALLLVFAGVMAACGSNNGAESGKKEIVVAATKTPHAE ILKEAEPLLKEKGYTLKVKVLSDYKMYNKALADKEVDANYFQHIPYLEQEMKENTDYK LVNAGAVHLEPFGIYSKTYKSLKDLPDGATIILTNNVAEQGRMLAMLENAGLITLDSK VETVDATLKDIKKNPKNLEFKKVAPELTAKAYENKEGDAVFINVNYAIQNKLNPKKDA IEVESTKNNPYANIIAVRKGEEDSAKIKALMEVLHSKKIKDFIEKKYDGAVLPVSE*" /label="metQ CDS" gene complement(2880011..2880835) /gene="metQ" /locus_tag="BSU_32730" /old_locus_tag="BSU32730" /label="metQ gene" downshifts complement(2880019) /Source="Nicolas_upshifts" /id="D1694" /incds=0 /nref=167 /ntot=246 /MaxReadThrough="2.13581" /MaxDrop="6.33517" /score="28.8468637" /energy="-12.6" /TU="NA" /idTUdmin="U2569" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" downshifts complement(2880168) /Source="Nicolas_upshifts" /id="D1695" /incds=1 /nref=2 /ntot=171 /MaxReadThrough="6.93658" /MaxDrop="2.3341" /score="28.8468637" /energy="-12.6" /TU="U2569" /idTUdmin="U2569" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-35 2880195..2880200 /Source="Nicolas_upshift_promotors" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2880216..2880234 /Source="Nicolas_upshift_promotors" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2880218 /Source="Nicolas_upshifts" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2880849..2881517) /gene="metP" /locus_tag="BSU_32740" /old_locus_tag="BSU32740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 15849754, 16850406, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 15849754, 16850406, 17038623; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter, permease component" /protein_id="NP_391153.1" /db_xref="EnsemblGenomes-Gn:BSU32740" /db_xref="EnsemblGenomes-Tr:CAB15263" /db_xref="GOA:O32168" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14014" /db_xref="UniProtKB/Swiss-Prot:O32168" /translation="MFEKYFPNVDLTELWNATYETLYMTLISLLFAFVIGVILGLLLF LTSKGSLWQNKAVNSVIAAVVNIFRSIPFLILIILLLGFTKFLVGTILGPNAALPALV IGSAPFYARLVEIALREVDKGVIEAAKSMGAKTSTIIFKVLIPESMPALISGITVTAI ALIGSTAIAGAIGSGGLGNLAYVEGYQSNNADVTFVATVFILIIVFIIQIIGDLITNI IDKR*" /label="metP CDS" gene complement(2880849..2881517) /gene="metP" /locus_tag="BSU_32740" /old_locus_tag="BSU32740" /label="metP gene" CDS complement(2881510..2882535) /gene="metN" /locus_tag="BSU_32750" /old_locus_tag="BSU32750" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 17038623; Product type t: transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter (ATP-binding protein)" /protein_id="NP_391154.1" /db_xref="EnsemblGenomes-Gn:BSU32750" /db_xref="EnsemblGenomes-Tr:CAB15264" /db_xref="GOA:O32169" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR017908" /db_xref="InterPro:IPR018449" /db_xref="InterPro:IPR026253" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14015" /db_xref="UniProtKB/Swiss-Prot:O32169" /translation="MINLQDVSKVYKSKHGDVNAVQNVSLSIKKGEIFGIIGYSGAGK SSLIRLLNGLEKPTSGTVEVAGTKINEVNGRGLRKARHEISMIFQHFNLLWSRTVRDN IMFPLEIAGVKKSERIKRANELIKLVGLEGKEKSYPSQLSGGQKQRVGIARALANNPK VLLCDEATSALDPQTTDSILDLLSDINERLGLTIVLITHEMHVIRKICNRVAVMENGK VVEEGEVLDVFKNPKEQMTKRFVQQVTEPEETKETLQHLLDDTASGKMVQLTFVGESA EQPLITEMIRNFNVSVNILQGKISQTKDGAYGSLFIHIDGDEEEVQNVIRFINDKQVK AEVITNV*" /label="metN CDS" gene complement(2881510..2882535) /gene="metN" /locus_tag="BSU_32750" /old_locus_tag="BSU32750" /label="metN gene" S_feature complement(2882536..2882640) /Source="Nicolas_S_feature" /locus_tag="new_3364292_3364396_c" /HighExp="MG 5, MG t5, MG 10, BMM, MG-0.2, GM 25, MG-0.1, MG 15, M9-exp, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1261" misc_RNA complement(2882641..2882747) /gene="mswH" /locus_tag="BSU_misc_RNA_53" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswH RNA" gene complement(2882641..2882747) /gene="mswH" /locus_tag="BSU_misc_RNA_53" /label="mswH gene" downshifts 2882710 /Source="Nicolas_upshifts" /id="D1696" /incds=0 /nref=2 /ntot=37 /MaxReadThrough="1.54417" /MaxDrop="5.51028" /score="-1.70178746" /energy="-11.2" /TU="NA" /idTUdmin="U2568" /TUdmin=2420 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2882774..2882793) /Source="Nicolas_upshift_promotors" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2882786) /Source="Nicolas_upshifts" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2882788..2882861) /Source="Nicolas_S_feature" /locus_tag="new_3364544_3364617_c" /HighExp="M9-stat, S2, LoTm, T5.0H, HiOs, B60, S3, T3.30H, LPhT, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.996, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1262" promotor_-35 complement(2882809..2882816) /Source="Nicolas_upshift_promotors" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2882862..2883206) /gene="yusD" /locus_tag="BSU_32760" /old_locus_tag="BSU32760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391155.1" /db_xref="EnsemblGenomes-Gn:BSU32760" /db_xref="EnsemblGenomes-Tr:CAB15265" /db_xref="InterPro:IPR003033" /db_xref="InterPro:IPR036527" /db_xref="SubtiList:BG14016" /db_xref="UniProtKB/Swiss-Prot:O32170" /translation="MEKAEVLEDEYQHLFLKPLLNASTLLITFQGEAEALTVSINEQG EMKKVSPPQTSNLTFYGNQTEIIDLLHGDISLQHLIQSGSLKVKGSFRALLKLEAILW LTNGFFQRILKN*" /label="yusD CDS" gene complement(2882862..2883206) /gene="yusD" /locus_tag="BSU_32760" /old_locus_tag="BSU32760" /label="yusD gene" S_feature complement(2883207..2883312) /Source="Nicolas_S_feature" /locus_tag="new_3364963_3365068_c" /HighExp="LPhT, HiOs, M9-stat, dia5, T2.0H, Diami, T1.30H, T0.30H, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA, SigA" /TUshortPSig="1, 0.996, 0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S1263" CDS complement(2883313..2883633) /gene="yusE" /locus_tag="BSU_32770" /old_locus_tag="BSU32770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154, 25875741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase with thioredoxin domain" /protein_id="NP_391156.1" /db_xref="EnsemblGenomes-Gn:BSU32770" /db_xref="EnsemblGenomes-Tr:CAB15266" /db_xref="GOA:O32171" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14017" /db_xref="UniProtKB/Swiss-Prot:O32171" /translation="MKELQEHELDHIEDDVYLLYLYTPFCGTCQLASKMLTVVKEMLP DVAFYQNNVNYSPTFAKAYQIESVPCFLLFKGGKMVERGYAFHSVSYLYELIKQKSSS ASHL*" /label="yusE CDS" gene complement(2883313..2883633) /gene="yusE" /locus_tag="BSU_32770" /old_locus_tag="BSU32770" /label="yusE gene" CDS complement(2883635..2884075) /gene="yusF" /locus_tag="BSU_32780" /old_locus_tag="BSU32780" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12794188; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease" /protein_id="NP_391157.1" /db_xref="EnsemblGenomes-Gn:BSU32780" /db_xref="EnsemblGenomes-Tr:CAB15267" /db_xref="GOA:O32172" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR034141" /db_xref="SubtiList:BG14018" /db_xref="UniProtKB/Swiss-Prot:O32172" /translation="MLAVNFTAFFYNLNISNLTRQVNKMKMDELEKVMIVEGKSDKEK IESVLNEPMRIICTNGTISQLRLEELADELYDKDVYILVDADESGEKLRKQLKREFNE ACHLHVDRAYKEVAAAPRHHIASVLLRANLNVHTIFLERKSRGV*" /label="yusF CDS" gene complement(2883635..2884075) /gene="yusF" /locus_tag="BSU_32780" /old_locus_tag="BSU32780" /label="yusF gene" CDS complement(2884075..2884311) /gene="yusG" /locus_tag="BSU_32790" /old_locus_tag="BSU32790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391158.1" /db_xref="EnsemblGenomes-Gn:BSU32790" /db_xref="EnsemblGenomes-Tr:CAB15268" /db_xref="InterPro:IPR020140" /db_xref="SubtiList:BG14019" /db_xref="UniProtKB/Swiss-Prot:O32173" /translation="MAFDKQKLDVTNDVTGRFQNGRLSLYHDNEMIGQMTSMNEYELK SGYSFENEKFYKTADVVSGDDAKYVDCDYENGWC*" /label="yusG CDS" gene complement(2884075..2884311) /gene="yusG" /locus_tag="BSU_32790" /old_locus_tag="BSU32790" /label="yusG gene" downshifts complement(2884087) /Source="Nicolas_upshifts" /id="D1697" /incds=0 /nref=35 /ntot=245 /MaxReadThrough="6.00162" /MaxDrop="3.9147" /score="-1.53913693" /energy="-11" /TU="U2570,U2571,U2572" /idTUdmin="U2574" /TUdmin=723 /isTUend="FALSE" /label="downshifts" upshifts complement(2884326) /Source="Nicolas_upshifts" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2884331..2884342) /Source="Nicolas_upshift_promotors" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2884357..2884363) /Source="Nicolas_upshift_promotors" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2884367..2884750) /gene="gcvH" /locus_tag="BSU_32800" /old_locus_tag="BSU32800" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 20882995, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine cleavage system protein H (lipoyl acceptor protein)" /protein_id="NP_391159.1" /db_xref="EnsemblGenomes-Gn:BSU32800" /db_xref="EnsemblGenomes-Tr:CAB15269" /db_xref="GOA:O32174" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR002930" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR017453" /db_xref="InterPro:IPR033753" /db_xref="SubtiList:BG14020" /db_xref="UniProtKB/Swiss-Prot:O32174" /translation="MSIPKDLRYSGEHEWVKVEGEKARIGITHFAQSELGDIVFVELP EVGAEIKADEPFGSVESVKTVSELYAPINGTVVEVNEDLDDSPEFVNESPYEKAWMIV VEPSDASEIEKLMTAEQYEEMTQED*" /label="gcvH CDS" gene complement(2884367..2884750) /gene="gcvH" /locus_tag="BSU_32800" /old_locus_tag="BSU32800" /label="gcvH gene" promotor_-10 complement(2884777..2884796) /Source="Nicolas_upshift_promotors" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="promotor_-10" upshifts complement(2884788) /Source="Nicolas_upshifts" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="upshifts" promotor_-35 complement(2884809..2884816) /Source="Nicolas_upshift_promotors" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="promotor_-35" CDS complement(2884817..2885173) /gene="yusI" /locus_tag="BSU_32810" /old_locus_tag="BSU32810" /EC_number="1.20.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase with thioredoxin domain and regulator domain" /protein_id="NP_391160.1" /db_xref="EnsemblGenomes-Gn:BSU32810" /db_xref="EnsemblGenomes-Tr:CAB15270" /db_xref="GOA:O32175" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14021" /db_xref="UniProtKB/Swiss-Prot:O32175" /translation="MSLTFYWYPKCGTCRKAKKWLEEHGKEINEIHIAEQPPSKEELK ALYEKSGLDLKKFFNTSGMKYRELNLKEKLYHMSEDEQLELLASDGMLIKRPLTTDGE KVTVGFKEDQFEENWA*" /label="yusI CDS" gene complement(2884817..2885173) /gene="yusI" /locus_tag="BSU_32810" /old_locus_tag="BSU32810" /label="yusI gene" promotor_-10 complement(2885196..2885215) /Source="Nicolas_upshift_promotors" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="promotor_-10" upshifts complement(2885206) /Source="Nicolas_upshifts" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="upshifts" promotor_-35 complement(2885229..2885234) /Source="Nicolas_upshift_promotors" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="promotor_-35" CDS complement(2885284..2887068) /gene="fadE" /locus_tag="BSU_32820" /old_locus_tag="BSU32820" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA dehydrogenase (FAD dependent)" /protein_id="NP_391161.1" /db_xref="EnsemblGenomes-Gn:BSU32820" /db_xref="EnsemblGenomes-Tr:CAB15271" /db_xref="GOA:O32176" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG14022" /db_xref="UniProtKB/Swiss-Prot:O32176" /translation="MAKKAADVQKGGGFLIEDVTYDQMYTPEDFTDEHKMIAKTTEDY IEQDVLPHIDDIENHQFEHSVRLLKKAGELGLLGADVPEEYGGLGLDKISSALITEKF SRAGSFSLSYGAHVGIGSLPIVFFGSEEQKKKYLPGLASGEKIAAYALTEPGSGSDAL GAKTTAVLNEAGTHYVLTGEKQWITNSAFADVFVVYAKVDGDKFSAFIVEKEFPGVST GPEEKKMGIKGSSTRTLILDQAEVPKENLLGEIGKGHVIAFNILNIGRYKLAVGTIGA SKRVIELSAAYANQRRQFKTPIAGFSLTQEKIGTMASRLYAMESSVYRTVGLFEDNMS QFTAEDLKDGRQIAKSIAEYAIECSLNKVFGSETLDYIVDEGVQIHGGYGFMQEYEVE RAYRDSRINRIFEGTNEINRLIVPSTFLKKALKGELPLFEKAQSLQEELMMLMPEEPG SGVLEQEKYIVKQAKKIALFAAGLAAQKYGKAIDREQEILVNVADIVSNVYAMESAVL RTEKAIAAQGAEKAAQKVLYTEIFVQEAFNEIEAHAKESLIAMEEGDSLRMMLSALRK LTRVTPKNVIQKKREAAAGIFEAEKYTV*" /label="fadE CDS" gene complement(2885284..2887068) /gene="fadE" /locus_tag="BSU_32820" /old_locus_tag="BSU32820" /label="fadE gene" downshifts complement(2885294) /Source="Nicolas_upshifts" /id="D1698" /incds=0 /nref=24 /ntot=46 /MaxReadThrough="4.78872" /MaxDrop="6.88218" /score="31.8022607" /energy="-16.4" /TU="U2574" /idTUdmin="U2576" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2887083..2888258) /gene="fadA" /locus_tag="BSU_32830" /old_locus_tag="BSU32830" /EC_number="2.3.1.16" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA C-acyltransferase" /protein_id="NP_391162.1" /db_xref="EnsemblGenomes-Gn:BSU32830" /db_xref="EnsemblGenomes-Tr:CAB15272" /db_xref="GOA:O32177" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020610" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020615" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="SubtiList:BG14023" /db_xref="UniProtKB/Swiss-Prot:O32177" /translation="MKEAVIVSGARTPVGKAKKGSLATVRPDDLGAICVKETLKRAGG YEGNIDDLIIGCATPEAEQGLNMARNIGALAGLPYTVPAITVNRYCSSGLQSIAYAAE KIMLGAYDTAIAGGAESMSQVPMMGHVTRPNLALAEKAPEYYMSMGHTAEQVAKKYGV SREDQDAFAVRSHQNAAKALAEGKFKDEIVPVEVTVTEIGEDHKPMEKQFVFSQDEGV RPQTTADILSTLRPAFSVDGTVTAGNSSQTSDGAAAVMLMDREKADALGLAPLVKFRS FAVGGVPPEVMGIGPVEAIPRALKLAGLQLQDIGLFELNEAFASQAIQVIRELGIDEE KVNVNGGAIALGHPLGCTGTKLTLSLIHEMKRRNEQFGVVTMCIGGGMGAAGVFELC* " /label="fadA CDS" gene complement(2887083..2888258) /gene="fadA" /locus_tag="BSU_32830" /old_locus_tag="BSU32830" /label="fadA gene" CDS complement(2888269..2890638) /gene="fadN" /locus_tag="BSU_32840" /old_locus_tag="BSU32840" /EC_number="1.1.1.35" /EC_number="4.2.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17189250, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase" /protein_id="NP_391163.2" /db_xref="EnsemblGenomes-Gn:BSU32840" /db_xref="EnsemblGenomes-Tr:CAB15273" /db_xref="GOA:O32178" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR006108" /db_xref="InterPro:IPR006176" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14024" /db_xref="UniProtKB/Swiss-Prot:O32178" /translation="MHKHIRKAAVLGSGVMGSGIAAHLANIGIPVLLLDIVPNDLTKE EEKKGLTKDSSEVRSRLSRQAMKKLLKQKPAPLTSAKNTSYITPGNLEDDAEKLKEAD WIIEVVVENLEVKKKIFALVDEHRKTGSIVSSNTSGISVQEMAEGRSDDFKAHFLGTH FFNPARYLKLLEIIPIKETDPDILKFMTAFGENVLGKGVVTAKDTPNFIANRIGTYGL LVTVQEMLKGGYQVGEVDSITGPLIGRPKSATFRTLDVVGLDTFAHVARNVYDKADGD EKEVFRIPSFMNDMLEKGWIGSKAGQGFYKKEGKTIYELDPVTLTYGERTKMKSPALE AAKQAKGTKAKMKALIYSDDRAGRLLWNITSQTLLYSAELLGEIADDIHAIDQAMKWG FGWELGPFEMWDAIGLKQSAEKLEQLGADMPGWIKEMLDKGNETFYIKENGTVFYYDR GEYRAVKENKKRIHLQALKETKGVIAKNSGASLIDLGDDVALLEFHSKSNAIGLDIIQ MIHKGLEETERNYKGLVIGNQGKNFCVGANLAMILMEVQDDNFLEVDFVIRRFQETMM KIKYSAKPVVAAPFGMTLGGGTEACLPAARIQAASEAYMGLVESGVGLIPGGGGNKEL YINHLRRGHDPMNAAMKTFETIAMAKVSASAQEAREMNILKETDQISVNQDHLLYDAK QLAASLYDTGWRPPVKEKVKVPGETGYAALLLGAEQMKLSGYISEHDFKIAKKLAYVI AGGKVPFGTEVDEEYLLEIEREAFLSLSGEAKSQARMQHMLVKGKPLRN*" /label="fadN CDS" gene complement(2888269..2890638) /gene="fadN" /locus_tag="BSU_32840" /old_locus_tag="BSU32840" /label="fadN gene" promotor_-35 2890057..2890062 /Source="Nicolas_upshift_promotors" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2890077..2890095 /Source="Nicolas_upshift_promotors" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2890080 /Source="Nicolas_upshifts" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2890706..2890725) /Source="Nicolas_upshift_promotors" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="promotor_-10" upshifts complement(2890709) /Source="Nicolas_upshifts" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="upshifts" S_feature complement(2890717..2890983) /Source="Nicolas_S_feature" /locus_tag="new_3372473_3372739_c" /HighExp="S8, S6, S7, BT, B36, G/S, B60, S5, Pyr, S3" /AntisenseName="yuzL" /AntisenseCor="0.77564732124057401" /AntisenseRegPval="-54.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1264" promotor_-35 complement(2890739..2890746) /Source="Nicolas_upshift_promotors" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="promotor_-35" promotor_-35 2890764..2890770 /Source="Nicolas_upshift_promotors" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2890785..2890796 /Source="Nicolas_upshift_promotors" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2890807 /Source="Nicolas_upshifts" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="upshifts" CDS 2890813..2890959 /gene="yuzL" /locus_tag="BSU_32849" /old_locus_tag="BSU32849" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17189250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097783.1" /db_xref="EnsemblGenomes-Gn:BSU32849" /db_xref="EnsemblGenomes-Tr:CAX52689" /db_xref="InterPro:IPR025625" /db_xref="UniProtKB/Swiss-Prot:C0H3R0" /translation="MVREKKNPSSAAVSAASVKGDAGPTQHYGGGKRTSQNQQYKKHN MGQS*" /label="yuzL CDS" gene 2890813..2890959 /gene="yuzL" /locus_tag="BSU_32849" /old_locus_tag="BSU32849" /label="yuzL gene" S_feature 2890960..2891986 /Source="Nicolas_S_feature" /locus_tag="new_3372716_3373742" /HighExp="S8, S5, S7, S4, S6, nit, ferm, T5.0H, S3, LoTm" /AntisenseName="fadM" /AntisenseCor="0.80952501049450498" /AntisenseRegPval="-63" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1265" CDS complement(2890984..2891892) /gene="putM" /locus_tag="BSU_32850" /old_locus_tag="BSU32850" /EC_number="1.5.5.2" /function="3.2: Degradation" /experiment="publication(s) with functional evidences, PMID:17189250, 17536821, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 17536821, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="proline dehydrogenase 1" /protein_id="NP_391164.1" /db_xref="EnsemblGenomes-Gn:BSU32850" /db_xref="EnsemblGenomes-Tr:CAB15274" /db_xref="GOA:O32179" /db_xref="InterPro:IPR002872" /db_xref="InterPro:IPR008219" /db_xref="InterPro:IPR015659" /db_xref="InterPro:IPR029041" /db_xref="SubtiList:BG14025" /db_xref="UniProtKB/Swiss-Prot:O32179" /translation="MLRHVFLFLSQNKTLTKFAKAYGTRLGARRFVAGDTIESAVKTV KRLNRSGLCATIDYLGEYAASEKEANQVAEECKKAIQAIAEHQLNSELSLKLTSIGLD LSEELALTHLRAILSVAKQYDVAVTIDMEDYSHYEQTLSIYRQCKQEFEKLGTVIQAY LYRAAEDIRKMRDLKPNLRLVKGAYKESAAVAFPDKRGTDLHFQSLIKLQLLSGNYTA VATHDDDIIAFTKQLVAEHQIPASQFEFQMLYGIRPERQKELAKEGYRMRVYVPYGTD WFSYFMRRIAERPANAAFVLKGILKK*" /label="putM CDS" gene complement(2890984..2891892) /gene="putM" /locus_tag="BSU_32850" /old_locus_tag="BSU32850" /label="putM gene" S_feature complement(2891893..2892415) /Source="Nicolas_S_feature" /locus_tag="new_3373649_3374171_c" /HighExp="S8, S6, S7, BT, B36, B60, G/S, Pyr, S5, SMMPr" /AntisenseName="yuzM" /AntisenseCor="0.77827902986544495" /AntisenseRegPval="-55.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1266" CDS 2891987..2892232 /gene="yuzM" /locus_tag="BSU_32859" /old_locus_tag="BSU32859" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097784.1" /db_xref="EnsemblGenomes-Gn:BSU32859" /db_xref="EnsemblGenomes-Tr:CAX52690" /db_xref="InterPro:IPR012347" /db_xref="UniProtKB/Swiss-Prot:C0H3R1" /translation="MDNQQQSQMPPSVISTKDHLYLNDMLNWNLLAMKKAHFMAQQCQ DQTLKQELDRVGHMHHDHYQRILKHLQPGQQQSGYIQ*" /label="yuzM CDS" gene 2891987..2892232 /gene="yuzM" /locus_tag="BSU_32859" /old_locus_tag="BSU32859" /label="yuzM gene" CDS 2892245..2892577 /gene="yusN" /locus_tag="BSU_32860" /old_locus_tag="BSU32860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat-like protein" /protein_id="NP_391165.1" /db_xref="EnsemblGenomes-Gn:BSU32860" /db_xref="EnsemblGenomes-Tr:CAB15275" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG14026" /db_xref="UniProtKB/Swiss-Prot:O32180" /translation="MNQQNQKISNPQTPVPTTSEMNDRDFVNELLTTEKYMTTAYCTA LHEFSHESLYQDIQSIFDESQKAQRKLYDLMFQYGWYSVEAEDSQKLQQSYQKFQQTI QQQSPYQQ*" /label="yusN CDS" gene 2892245..2892577 /gene="yusN" /locus_tag="BSU_32860" /old_locus_tag="BSU32860" /label="yusN gene" promotor_-10 complement(2892398..2892417) /Source="Nicolas_upshift_promotors" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2892415) /Source="Nicolas_upshifts" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2892431..2892440) /Source="Nicolas_upshift_promotors" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2892566 /Source="Nicolas_upshifts" /id="D1699" /incds=0 /nref=24 /ntot=46 /MaxReadThrough="2.684" /MaxDrop="5.38418" /score="9.88876972" /energy="-10.2" /TU="NA" /idTUdmin="U2575" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2892638..2892645 /Source="Nicolas_upshift_promotors" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2892659..2892678 /Source="Nicolas_upshift_promotors" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2892670 /Source="Nicolas_upshifts" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="upshifts" CDS 2892736..2893203 /gene="mdtR" /locus_tag="BSU_32870" /old_locus_tag="BSU32870" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12923086, 19286808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12923086, 19286808; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MarR family, low level antibiotic resistance)" /protein_id="NP_391166.1" /db_xref="EnsemblGenomes-Gn:BSU32870" /db_xref="EnsemblGenomes-Tr:CAB15276" /db_xref="GOA:O32181" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1S3J" /db_xref="SubtiList:BG14027" /db_xref="UniProtKB/Swiss-Prot:O32181" /translation="MKSADQLMSDIQLSLQALFQKIQPEMLESMEKQGVTPAQLFVLA SLKKHGSLKVSEIAERMEVKPSAVTLMADRLEQKNLIARTHNTKDRRVIDLSLTDEGD IKFEEVLAGRKAIMARYLSFLTEEEMLQAAHITAKLAQAAETDEKQNMKRGNG*" /label="mdtR CDS" gene 2892736..2893203 /gene="mdtR" /locus_tag="BSU_32870" /old_locus_tag="BSU32870" /label="mdtR gene" CDS 2893200..2894825 /gene="mdtP" /locus_tag="BSU_32880" /old_locus_tag="BSU32880" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19286808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19286808; Product type t: transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_391167.1" /db_xref="EnsemblGenomes-Gn:BSU32880" /db_xref="EnsemblGenomes-Tr:CAB15277" /db_xref="GOA:O32182" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14028" /db_xref="UniProtKB/Swiss-Prot:O32182" /translation="MKMSKEGKQSKRTLLITGLIIAMFFSALDGTIVGTAMPKIVGDL GGLSMMTWLTTAYLLTSTTIVPIAGKLADLLGRRIVYVSGLIIFMAASALCGMANNMT ELIIFRGLQGIGGGIMMPMAMIVIGDLFTGKQRAKFQGVFGAIYGLASVIGPQIGGWI VDSLNWKWVFYINLPVGIIAVIFIARGLQGRQQTGPINFDIAGIFTMIVGVVSLLLAL SFGGKDYAWDSWQILGLFALALIGIVSFIIVESKAKEPILPMYLFKNRTFTFLNLIGF FMSIGMFGAITFVPFFMQGIVGVSASESGTIMTPMMISMIITSIIGGQLVYKIGIKPQ IITGMLVMAGGFLLLTTLDLDTSKLVATSFMAIIGLGMGLVMPILTLALQESFSKEEL GVVTSSSQFFRSIGGTFGITMLGAVMNARSGNLLTDKLVPYLDSLPAQASSFAAQLKG MIDTNPQGLLQSLFSPDAVKQIPAAFSSHIVPILKTSLMDSLHSVFYTGLIFIAVGAV FTLFLKPIKLSNKKAEDQQEKEKAAKAVESPSH*" /label="mdtP CDS" gene 2893200..2894825 /gene="mdtP" /locus_tag="BSU_32880" /old_locus_tag="BSU32880" /label="mdtP gene" downshifts 2894810 /Source="Nicolas_upshifts" /id="D1700" /incds=0 /nref=217 /ntot=257 /MaxReadThrough="0.3188" /MaxDrop="5.64223" /score="42.0555168" /energy="-17.7" /TU="NA" /idTUdmin="U2577" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2894861..2895244) /gene="yusQ" /locus_tag="BSU_32890" /old_locus_tag="BSU32890" /EC_number="5.3.2.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 25219626; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydratase of unidentified specificity (tautomerase superfamily)" /protein_id="NP_391168.1" /db_xref="EnsemblGenomes-Gn:BSU32890" /db_xref="EnsemblGenomes-Tr:CAB15278" /db_xref="GOA:O32183" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="SubtiList:BG14029" /db_xref="UniProtKB/Swiss-Prot:O32183" /translation="MPFVQIHLRSGRSEVWLQKLSRTIHQSMIEEINVPEDDYFQVIR QYEKSEFFYDPFYLQVERTDELIYIHFTLKQSRTTEQKKALYRSIASRIHSELGVRKE DVFIMLAGNQDEDWSFGNGRAQMIE*" /label="yusQ CDS" gene complement(2894861..2895244) /gene="yusQ" /locus_tag="BSU_32890" /old_locus_tag="BSU32890" /label="yusQ gene" CDS complement(2895263..2895652) /gene="yusR" /locus_tag="BSU_32900" /old_locus_tag="BSU32900" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15294834; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 3-oxoacyl-acyl-carrier protein reductase" /protein_id="NP_391169.1" /db_xref="EnsemblGenomes-Gn:BSU32900" /db_xref="EnsemblGenomes-Tr:CAB15279" /db_xref="GOA:O32184" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14030" /db_xref="UniProtKB/Swiss-Prot:O32184" /translation="MKGMFFCARAVVPFMKKSKDGAIVNVGSIAGITGAGSSMPYAVS KSAVHGLTKSLAHALAPEIRVSGVAPGAVATRWWAGREEKMKSMIGSLLLQCIAEPDD VAKLICSLIEQESLTGQIITIDSGQTL*" /label="yusR CDS" gene complement(2895263..2895652) /gene="yusR" /locus_tag="BSU_32900" /old_locus_tag="BSU32900" /label="yusR gene" CDS complement(2895674..2896003) /gene="yusS" /locus_tag="BSU_32910" /old_locus_tag="BSU32910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved enzyme of unknown function" /protein_id="NP_391170.1" /db_xref="EnsemblGenomes-Gn:BSU32910" /db_xref="EnsemblGenomes-Tr:CAB15280" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14031" /db_xref="UniProtKB/Swiss-Prot:O32185" /translation="MNVLNKIALVTGGGTGIGKAASMELAKRGAIVAVNYSRSQSEAE ETVEMIQKAGGQAFAIQADVSKNSDVQDMIQAIVNTHGTVDILVNNASITRHIPMDDL EAATEDV*" /label="yusS CDS" gene complement(2895674..2896003) /gene="yusS" /locus_tag="BSU_32910" /old_locus_tag="BSU32910" /label="yusS gene" promotor_-10 complement(2896038..2896057) /Source="Nicolas_upshift_promotors" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2896045..2896052 /Source="Nicolas_upshift_promotors" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2896052) /Source="Nicolas_upshifts" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2896067..2896086 /Source="Nicolas_upshift_promotors" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2896071..2896078) /Source="Nicolas_upshift_promotors" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2896077 /Source="Nicolas_upshifts" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="upshifts" CDS 2896137..2897024 /gene="yusT" /locus_tag="BSU_32920" /old_locus_tag="BSU32920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169591, 17526699, 27965289" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169591, 17526699, 27965289; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of unknown specificity(LysR family)" /protein_id="NP_391171.1" /db_xref="EnsemblGenomes-Gn:BSU32920" /db_xref="EnsemblGenomes-Tr:CAB15281" /db_xref="GOA:O32186" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14032" /db_xref="UniProtKB/Swiss-Prot:O32186" /translation="MESGDLRVFQMVAREGTITKAALQLGYVQSNVTARIQQLEAELG TTLFLRHNRGMTLSASGKLLLDYANKIIGLLDEASKALSSSAEPSGPLMIGCTQTTAA VRLPKLLASYYEEHPNVQLSLTTGHTQFLLDKVLRYELDGAFIGCECHHPELESYPAF EEEPVVVSAASVPDVEEAITKPILVYSTGCSYRETLEKWLRSVGVTQPVIMEFGTLEA IIGGVTAGLGISLLPRTVVQKHEAEGSIRLYPLPEALSQMKTEFIVRKDSFISSALRT FMDSFTPVKTAESQKSSLL*" /label="yusT CDS" gene 2896137..2897024 /gene="yusT" /locus_tag="BSU_32920" /old_locus_tag="BSU32920" /label="yusT gene" CDS complement(2897044..2897331) /gene="yusU" /locus_tag="BSU_32930" /old_locus_tag="BSU32930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22078549" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391172.1" /db_xref="EnsemblGenomes-Gn:BSU32930" /db_xref="EnsemblGenomes-Tr:CAB15282" /db_xref="InterPro:IPR020393" /db_xref="SubtiList:BG14033" /db_xref="UniProtKB/Swiss-Prot:O32187" /translation="MRKLLAVFSKGRWKMEQKLQEQLDGLLEKYTELLLGETNDELKE EVKQWILYTHIAKSMPPLAKHWNATYPDAKQGIKEIIQHIKELNEAHRNKQ*" /label="yusU CDS" gene complement(2897044..2897331) /gene="yusU" /locus_tag="BSU_32930" /old_locus_tag="BSU32930" /label="yusU gene" downshifts complement(2897056) /Source="Nicolas_upshifts" /id="D1701" /incds=0 /nref=113 /ntot=280 /MaxReadThrough="1.05563" /MaxDrop="5.97768" /score="17.1690128" /energy="-13.2" /TU="NA" /idTUdmin="U2580" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(2897356..2898183) /gene="feuV" /locus_tag="BSU_32940" /old_locus_tag="BSU32940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 16672620, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16672620, 24847778, 25288929; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron(III)-siderophore transporter (ATP binding component)" /protein_id="NP_391173.1" /db_xref="EnsemblGenomes-Gn:BSU32940" /db_xref="EnsemblGenomes-Tr:CAB15283" /db_xref="GOA:O32188" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14034" /db_xref="UniProtKB/Swiss-Prot:O32188" /translation="MGMSAISTETLSLGYGDAVIIDELNLTIPKGEITVFIGSNGCGK STLLRSLARLMKPRGGSVLLEGRAIAKLPTKEVAKELAILPQGPSAPEGLTVHQLVKQ GRYPYQNWLKQWSKEDEEAVERALKATKLEDMADRAVDSLSGGQRQRAWIAMTLAQET DIILLDEPTTYLDMTHQIEILDLLFELNEKEDRTIVMVLHDLNLACRYAHHLVAIKDK RIYAEGRPEEVITCDLVQNVFSMNCQVTQDPLFGTPLCIPHGRGRCIVQEAAFTSHG* " /label="feuV CDS" gene complement(2897356..2898183) /gene="feuV" /locus_tag="BSU_32940" /old_locus_tag="BSU32940" /label="feuV gene" downshifts complement(2897372) /Source="Nicolas_upshifts" /id="D1702" /incds=0 /nref=2 /ntot=77 /MaxReadThrough="5.36684" /MaxDrop="3.19022" /score="11.3999731" /energy="-19.8" /TU="U2580" /idTUdmin="U2581" /TUdmin=220 /isTUend="FALSE" /label="downshifts" S_feature complement(2898184..2898321) /Source="Nicolas_S_feature" /locus_tag="new_3379940_3380077_c" /HighExp="T-5.40H, Paraq, H2O2, GM-0.2, HiOs, GM 5, dia15, GM 25, T-3.40H, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1267" promotor_-10 complement(2898306..2898325) /Source="Nicolas_upshift_promotors" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2898321) /Source="Nicolas_upshifts" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2898341..2898344) /Source="Nicolas_upshift_promotors" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2898401..2898838) /gene="cotNW" /locus_tag="BSU_32950" /old_locus_tag="BSU32950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 26497467; Product type m : membrane component" /codon_start=1 /transl_table=11 /product="spore lipoprotein" /protein_id="NP_391174.1" /db_xref="EnsemblGenomes-Gn:BSU32950" /db_xref="EnsemblGenomes-Tr:CAB15284" /db_xref="InterPro:IPR025623" /db_xref="SubtiList:BG14035" /db_xref="UniProtKB/Swiss-Prot:O32189" /translation="MHLIRAAGAVCLAVVLIAGCRFNEDQHQAEGENTAVTQLKSVPY SNFSLRVSYGDGEHNRYEGIYTKNGTQEKAEIQDKLSGVNQEGEEALDEMKMILSELS VTDQMAETEVIHSVLAAFNLDSHYDHIDLKLKLKDGSIREIKK*" /label="cotNW CDS" gene complement(2898401..2898838) /gene="cotNW" /locus_tag="BSU_32950" /old_locus_tag="BSU32950" /label="cotNW gene" promotor_-10 complement(2898862..2898880) /Source="Nicolas_upshift_promotors" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="promotor_-10" upshifts complement(2898868) /Source="Nicolas_upshifts" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="upshifts" promotor_-35 complement(2898896..2898901) /Source="Nicolas_upshift_promotors" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="promotor_-35" CDS complement(2898948..2900456) /gene="yusYc" /locus_tag="BSU_32960" /old_locus_tag="BSU32960" /EC_number="3.4.24.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11741842; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="oligoendopeptidase; C-terminal part of YusY" /db_xref="SubtiList:BG14037" /translation="GLMNRLSADFQSSLVTLDHKLVDINQDVWNELLTKPGLRDVSYI LNERRQRVAEKLSPGKEKLIGNLAVDGYHAWSDLYNMVVGKMTIPYEENGENKQLSVG QAENMMDHQDRTVRKTVYERFRQAWESKQDIFSSTLNHLAGFRLETYKARGWENVLKE PLQINRMKKETLDTMWQVITENKKPFVQFLNRKASMLGLEKLSWYDVEAPIGSDGKVY SYDEAANIITSQFSTFGKKLSSFTEKAFRDGWIEAEDRSGKRVGGFCTSFPDSGESRI FMTFSGSASNVSTLAHELGHAFHQEAMLNVRPLNRSYAMNVAETASTFAEMIVADATV QQAETREEKLVLLEDKVQRSVAFFMNIHARFLFETRFYEERKRGVVPASRLNELMEEA QREAYCNALEEYHPLFWASKLHFHITRVPFYNFPYTFGYLFSLGIYALALEEKDTFEE KYMALLRDTASMTVEDLAMKHLGADITKRDFWENAIKLAVRDAETFLQMTES*" /label="yusYc CDS" gene complement(2898948..2900456) /gene="yusYc" /locus_tag="BSU_32960" /old_locus_tag="BSU32960" /pseudo /label="yusYc gene" downshifts complement(2898969) /Source="Nicolas_upshifts" /id="D1703" /incds=0 /nref=125 /ntot=240 /MaxReadThrough="2.57385" /MaxDrop="6.5698" /score="6.83314975" /energy="-12" /TU="NA" /idTUdmin="U2582" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" CDS complement(2900447..2900743) /gene="yusYn" /locus_tag="BSU_32970" /old_locus_tag="BSU32970" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11741842; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="oligoendopeptidase; N-terminal part of YusY" /translation="MALQGVGQRWDLDSFFKGGSQSEEFKGYIEKLSQSLRAFQDRTD AFQVPESPEEAEGLTALLDLFEQTSVKLQQAGAFVACLQAQNINDQKAIEHQAS*" /label="yusYn CDS" gene complement(2900447..2900743) /gene="yusYn" /locus_tag="BSU_32970" /old_locus_tag="BSU32970" /pseudo /label="yusYn gene" promotor_-10 complement(2900766..2900785) /Source="Nicolas_upshift_promotors" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2900782) /Source="Nicolas_upshifts" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2900800..2900803) /Source="Nicolas_upshift_promotors" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2900820..2900825 /Source="Nicolas_upshift_promotors" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2900837..2900856 /Source="Nicolas_upshift_promotors" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2900837 /Source="Nicolas_upshifts" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="upshifts" CDS 2900877..2901719 /gene="yusZ" /locus_tag="BSU_32980" /old_locus_tag="BSU32980" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative short-chain acyl dehydrogenase" /protein_id="NP_391177.1" /db_xref="EnsemblGenomes-Gn:BSU32980" /db_xref="EnsemblGenomes-Tr:CAB15287" /db_xref="GOA:P37959" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10863" /db_xref="UniProtKB/Swiss-Prot:P37959" /translation="MNKKIAIVTGASSGFGLLAAVKLARSFFVIATSRQPEKAEQLRE LAAAHNVSDSIHITALDVTDEQSIVSFGKAVSAYAPIDLLVNNAGTAYGGFIEDVPME HFRQQFETNVFGVIHVTKTVLPYIRKHGGAKIINVSSISGLTGFPALSPYVSSKHALE GFSESLRIELLPFGIETALIEPGSYKTSIWSTSLSNFMSVPADDSAYHQYYKKILSYV QKNGEESGDPQEVADLIYQLATKQHIKNLRYPIGKGIKLTLLFRSLFPWSAWESILKK KLFS*" /label="yusZ CDS" gene 2900877..2901719 /gene="yusZ" /locus_tag="BSU_32980" /old_locus_tag="BSU32980" /label="yusZ gene" promotor_-35 2901249..2901255 /Source="Nicolas_upshift_promotors" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="promotor_-35" promotor_-10 2901270..2901281 /Source="Nicolas_upshift_promotors" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="promotor_-10" upshifts 2901278 /Source="Nicolas_upshifts" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="upshifts" promotor_-35 2901746..2901753 /Source="Nicolas_upshift_promotors" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2901762 /Source="Nicolas_upshifts" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2901765..2901784 /Source="Nicolas_upshift_promotors" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2901809..2902270 /gene="mrgA" /locus_tag="BSU_32990" /old_locus_tag="BSU32990" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12029044, 8709848, 21057011, 22194458, 24123749, 28434086" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 8709848, 21057011, 22194458, 24123749, 28434086; Product type f : factor" /codon_start=1 /transl_table=11 /product="metalloregulation DNA-binding stress protein" /protein_id="NP_391178.1" /db_xref="EnsemblGenomes-Gn:BSU32990" /db_xref="EnsemblGenomes-Tr:CAB15288" /db_xref="GOA:P37960" /db_xref="InterPro:IPR002177" /db_xref="InterPro:IPR008331" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR023188" /db_xref="PDB:2CHP" /db_xref="SubtiList:BG10864" /db_xref="UniProtKB/Swiss-Prot:P37960" /translation="MKTENAKTNQTLVENSLNTQLSNWFLLYSKLHRFHWYVKGPHFF TLHEKFEELYDHAAETVDTIAERLLAIGGQPVATVKEYTEHASITDGGNETSASEMVQ ALVNDYKQISSESKFVIGLAEENQDNATADLFVGLIEEVEKQVWMLSSYLG*" /label="mrgA CDS" gene 2901809..2902270 /gene="mrgA" /locus_tag="BSU_32990" /old_locus_tag="BSU32990" /label="mrgA gene" downshifts 2902246 /Source="Nicolas_upshifts" /id="D1704" /incds=0 /nref=234 /ntot=274 /MaxReadThrough="1.7919" /MaxDrop="8.26581" /score="36.5549876" /energy="-13.3" /TU="NA" /idTUdmin="U2583" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2902314..2903690) /gene="htrB" /locus_tag="BSU_33000" /old_locus_tag="BSU33000" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11133960, 11717295, 16033468, 16911528, 22307758, 23937099, 24362423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11133960, 11717295, 16033468, 16911528, 22307758, 23937099, 24362423; Product type f: factor" /codon_start=1 /transl_table=11 /product="protease-associated chaperone for the extracytoplasmic folding and quality control of exported proteins" /protein_id="NP_391180.2" /db_xref="EnsemblGenomes-Gn:BSU33000" /db_xref="EnsemblGenomes-Tr:CAB15290" /db_xref="GOA:Q9R9I1" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG14155" /db_xref="UniProtKB/Swiss-Prot:Q9R9I1" /translation="MDYRRDGQNDQHQTEPSHTEQQNTENQKLIGHSEQELLDAPVSY EAGRQETASALEMEKQETAVKKEKKRRAAWLSPILGGIIGGGLMLGIAPYLPSDQNQA TETASANKQVQSDNFTTAPITNASNIADMVEDLEPTIVGISNIQTSQNNTFGTGGGSS SESESGTGSGVIFKKDSDKAYIITNNHVVEGANKLTVTLYNGETETAKLVGSDTITDL AVLEISGKNVKKVASFGDSSQLRTGEKVIAIGNPLGQQFSGTVTQGIISGLNRTIDVD TTQGTVEMNVLQTDAAINPGNSGGPLINASGQVIGINSLKVSESGVESLGFAIPSNDV EPIVDQLLQNGKVDRPFLGVQMIDMSQVPETYQENTLGLFGDQLGKGVYVKEVQANSP AEKAGIKSEDVIVKLNGKDVESSADIRQILYKDLKVGDKTTIQVLRKGKTKTLNATLT KQTESSSS*" /label="htrB CDS" gene complement(2902314..2903690) /gene="htrB" /locus_tag="BSU_33000" /old_locus_tag="BSU33000" /label="htrB gene" downshifts complement(2902322) /Source="Nicolas_upshifts" /id="D1705" /incds=0 /nref=206 /ntot=257 /MaxReadThrough="1.84997" /MaxDrop="6.39104" /score="17.1953741" /energy="-11.2" /TU="U2586" /idTUdmin="U2586" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" S_feature complement(2903691..2903862) /Source="Nicolas_S_feature" /locus_tag="new_3385447_3385618_c" /HighExp="SMMPr, T-0.40H, T-1.10H, M9-tran, T-1.40H, T1.0H, T0.30H, T1.30H, Etha, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.67259999999999998" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1268" promotor_-10 complement(2903843..2903862) /Source="Nicolas_upshift_promotors" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2903862) /Source="Nicolas_upshifts" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2903873..2903880) /Source="Nicolas_upshift_promotors" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2903923..2903942) /Source="Nicolas_upshift_promotors" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="promotor_-10" misc_feature 2903933..2903952 /Source="Nicolas_upshift_promotors" /id="U2587" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.994005994005994" /xcortree=2013 /SigmaFactorBS="gggataaaaatgaaaagaatatgtgaaattatgaaaattgcc tgccgtatgttaaaacTAGTTTATAATGACGTTGAAaggatgtgaagagccttgtcat a" /listShort="cssR, cssS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2903935 /Source="Nicolas_upshifts" /id="U2587" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.994005994005994" /xcortree=2013 /SigmaFactorBS="gggataaaaatgaaaagaatatgtgaaattatgaaaattgcc tgccgtatgttaaaacTAGTTTATAATGACGTTGAAaggatgtgaagagccttgtcat a" /listShort="cssR, cssS" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2903941) /Source="Nicolas_upshifts" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="upshifts" S_feature complement(2903943..2905006) /Source="Nicolas_S_feature" /locus_tag="new_3385699_3386762_c" /HighExp="T1.0H, T0.30H, T1.30H, C30, T2.0H, G135, G180, T2.30H, ferm, G150" /AntisenseName="cssR" /AntisenseCor="0.115381389160342" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1269" promotor_-35 complement(2903957..2903964) /Source="Nicolas_upshift_promotors" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="promotor_-35" CDS 2903968..2904645 /gene="cssR" /locus_tag="BSU_33010" /old_locus_tag="BSU33010" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185; Product type r: regulator" /codon_start=1 /transl_table=11 /product="folding stress-sensitive two-component response regulator" /protein_id="NP_391181.1" /db_xref="EnsemblGenomes-Gn:BSU33010" /db_xref="EnsemblGenomes-Tr:CAB15291" /db_xref="GOA:O32192" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14131" /db_xref="UniProtKB/Swiss-Prot:O32192" /translation="MSYTIYLVEDEDNLNELLTKYLENEGWNITSFTKGEDARKKMTP SPHLWILDIMLPDTDGYTLIKEIKAKDPDVPVIFISARDADIDRVLGLELGSNDYISK PFLPRELIIRVQKLLQLVYKEAPPVQKNEIAVSSYRVAEDAREVYDENGNIINLTSKE FDLLLLFIHHKGHPYSREDILLKVWGHDYFGTDRVVDDLVRRLRRKMPELKVETIYGF GYRMMSS*" /label="cssR CDS" gene 2903968..2904645 /gene="cssR" /locus_tag="BSU_33010" /old_locus_tag="BSU33010" /label="cssR gene" CDS 2904642..2905997 /gene="cssS" /locus_tag="BSU_33020" /old_locus_tag="BSU33020" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="folding stress-sensitive two-component sensor histidine kinase" /protein_id="NP_391182.2" /db_xref="EnsemblGenomes-Gn:BSU33020" /db_xref="EnsemblGenomes-Tr:CAB15292" /db_xref="GOA:O32193" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14132" /db_xref="UniProtKB/Swiss-Prot:O32193" /translation="MKNKPLAFQIWVVISGILLAISILLLVLFSNTLRDFFTNETYTT IENEQHVLTEYRLPGSIERRYYSEEATAPTTVRSVQHVLLPENEEASSDKDLSILSSS FIHKVYKLADKQEAKKKRYSADVNGEKVFFVIKKGLSVNGQSAMMLSYALDSYRDDLA YTLFKQLLFIIAVVILLSWIPAIWLAKYLSRPLVSFEKHVKRISEQDWDDPVKVDRKD EIGKLGHTIEEMRQKLVQKDETERTLLQNISHDLKTPVMVIRGYTQSIKDGIFPKGDL ENTVDVIECEALKLEKKIKDLLYLTKLDYLAKQKVQHDMFSIVEVTEEVIERLKWARK ELSWEIDVEEDILMPGDPEQWNKLLENILENQIRYAETKIEISMKQDDRNIVITIKND GPHIEDEMLSSLYEPFNKGKKGEFGIGLSIVKRILTLHKASISIENDKTGVTYRIAVP K*" /label="cssS CDS" gene 2904642..2905997 /gene="cssS" /locus_tag="BSU_33020" /old_locus_tag="BSU33020" /label="cssS gene" S_feature complement(2905096..2906024) /Source="Nicolas_S_feature" /locus_tag="new_3386852_3387780_c" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, ferm, C30, LPhT, T-1.10H, Lbstat" /AntisenseName="cssS" /AntisenseCor="0.27217686232372901" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigD, SigH, SigA" /TUshortPSig="1, 0.869, 1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1270" downshifts 2905965 /Source="Nicolas_upshifts" /id="D1706" /incds=0 /nref=61 /ntot=203 /MaxReadThrough="0.95076" /MaxDrop="4.47937" /score="13.0972324" /energy="-9.7" /TU="NA" /idTUdmin="U2587" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2906025..2906189) /gene="spxO" /locus_tag="BSU_33029" /old_locus_tag="BSU33029" /experiment="publication(s) with functional evidences, PMID:21378193" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21378193; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of SpxA degradation" /protein_id="YP_003097785.1" /db_xref="EnsemblGenomes-Gn:BSU33029" /db_xref="EnsemblGenomes-Tr:CAX52691" /db_xref="GOA:O32302" /db_xref="UniProtKB/Swiss-Prot:O32302" /translation="MRELDEMISRLRNRGIKVEKVKYPKQTLSEKKWVHQCKQPLKTN YRDFNGYSFT*" /label="spxO CDS" gene complement(2906025..2906189) /gene="spxO" /locus_tag="BSU_33029" /old_locus_tag="BSU33029" /label="spxO gene" promotor_-35 2906213..2906220 /Source="Nicolas_upshift_promotors" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2906234..2906253 /Source="Nicolas_upshift_promotors" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2906238..2906257) /Source="Nicolas_upshift_promotors" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2906244..2906356 /Source="Nicolas_S_feature" /locus_tag="new_3388000_3388112" /HighExp="dia5, Diami, T0.30H, T-0.40H, T0.0H, dia15, Salt, ferm, G135, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1271" upshifts 2906244 /Source="Nicolas_upshifts" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2906251) /Source="Nicolas_upshifts" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2906253..2906531) /Source="Nicolas_S_feature" /locus_tag="new_3388009_3388287_c" /HighExp="Etha, Gly, S2, Glucon, Pyr, G/S, S1, Lbstat, Cold, HiTm" /AntisenseName="yuxN" /AntisenseCor="-0.128326996122899" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigH, SigA" /TUshortPSig="0.869, 1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1272" promotor_-35 complement(2906271..2906278) /Source="Nicolas_upshift_promotors" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2906357..2907232 /gene="yuxN" /locus_tag="BSU_33030" /old_locus_tag="BSU33030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391183.1" /db_xref="EnsemblGenomes-Gn:BSU33030" /db_xref="EnsemblGenomes-Tr:CAB15293" /db_xref="GOA:P40950" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG11072" /db_xref="UniProtKB/Swiss-Prot:P40950" /translation="MKEKEKLIIETALKLFAQKGYNSTSVQEIAKECKISKGAFYIYF PSKEALLLSMLNYYYDKTFTRILNIKTKGDSPRTAYRKQLTVLYENILEHKDFISMQL KEGSLPYTEEVEQCAKKIRQSSLQFHIDSLLNIYGKKAEPYTAELCFLIEGISQIYLE CMILLGYTVKPSQLADIIMNRIDDMVKGMSERNDKPFITLEEASSLFGPLTHGRPDPL TESIVKSLRDKINSLNTNSSLELSESLDILEAEMKKKTPKLAIIKGMIHNLTESEALA KDAEQLKYLLKQQHI*" /label="yuxN CDS" gene 2906357..2907232 /gene="yuxN" /locus_tag="BSU_33030" /old_locus_tag="BSU33030" /label="yuxN gene" promotor_-10 complement(2906521..2906540) /Source="Nicolas_upshift_promotors" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2906531) /Source="Nicolas_upshifts" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2906533..2907074) /Source="Nicolas_S_feature" /locus_tag="new_3388289_3388830_c" /HighExp="LBGstat, Cold, S2, Glucon, S1, Pyr, G/S, C30, GM 10, GM-0.1" /AntisenseName="yuxN" /AntisenseCor="-0.341746670828522" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigH, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1273" promotor_-35 complement(2906554..2906561) /Source="Nicolas_upshift_promotors" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2907066..2907084) /Source="Nicolas_upshift_promotors" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2907074) /Source="Nicolas_upshifts" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2907076..2907205) /Source="Nicolas_S_feature" /locus_tag="new_3388832_3388961_c" /HighExp="S2, S1, G/S, Glucon, Pyr, T3.30H, M9-stat, BT, Cold, T4.0H" /AntisenseName="yuxN" /AntisenseCor="-0.30886083736579201" /AntisenseRegPval="-6.6" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1274" promotor_-35 complement(2907097..2907104) /Source="Nicolas_upshift_promotors" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2907207 /Source="Nicolas_upshifts" /id="D1707" /incds=0 /nref=30 /ntot=182 /MaxReadThrough="3.14099" /MaxDrop="3.7614" /score="-3.47814442" /energy="-13.6" /TU="NA" /idTUdmin="U2589" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" downshifts complement(2907250) /Source="Nicolas_upshifts" /id="D1708" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="5.30537" /MaxDrop="3.29426" /score="-2.73895091" /energy="-13.6" /TU="U2593,U2594" /idTUdmin="U2591" /TUdmin="-1584" /isTUend="FALSE" /label="downshifts" CDS complement(2907268..2908656) /gene="fumC" /locus_tag="BSU_33040" /old_locus_tag="BSU33040" /EC_number="4.2.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:2509422, 3130545, 3923430, 9647666, 22914898, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2509422, 3130545, 3923430, 9647666, 22914898, 28032445; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="fumarate hydratase" /protein_id="NP_391184.1" /db_xref="EnsemblGenomes-Gn:BSU33040" /db_xref="EnsemblGenomes-Tr:CAB15294" /db_xref="GOA:P07343" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR005677" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR018951" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10384" /db_xref="UniProtKB/Swiss-Prot:P07343" /translation="MEYRIERDTMGEVKVPADKFWGAQTQRSKENFKIGSEKMPMRVV KAFAILKRSTALANKRLGNLDAEKAEAIAAVCDDVLKGKYDDNFPLVVWQTGSGTQSN MNMNEVVANRATALLKEKNSDQTIHPNDDVNRSQSSNDTFPTAMHVAAVLAVYEQLVP ALDQLRNTLDEKAKAYNDIVKIGRTHLQDATPLTLGQEISGWVHMLDRSKEMILEATD KMRALAIGGTAVGTGINAHPEFGELVSEEITKLTGQTFSSSPNKFHALTSHDEITYAH GALKALAADLMKIANDVRWLASGPRCGIGEIVIPENEPGSSIMPGKVNPTQSEALTMI AAQIMGNDATIGFAASQGNFELNVFKPVIIYNFLQSVQLLSDGMNSFHDKCAVGIEPN KETIQENLSNSLMLVTALNPHIGYENAAKIAKLAHKEGLTLKEAALKLELLTEEQFNE MVKPEDMVKPKA*" /label="fumC CDS" gene complement(2907268..2908656) /gene="fumC" /locus_tag="BSU_33040" /old_locus_tag="BSU33040" /label="fumC gene" upshifts complement(2908680) /Source="Nicolas_upshifts" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2908685..2908703) /Source="Nicolas_upshift_promotors" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2908714..2908722) /Source="Nicolas_upshift_promotors" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2908723..2908908) /gene="yvzF" /locus_tag="BSU_33049" /old_locus_tag="BSU33049" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097786.1" /db_xref="EnsemblGenomes-Gn:BSU33049" /db_xref="EnsemblGenomes-Tr:CAX52692" /db_xref="InterPro:IPR025088" /db_xref="UniProtKB/Swiss-Prot:C0H3R3" /translation="MAQVRLAGKQEEIEQLIRSFEQHYDVSYTSKEYGRTNPKYKYSK DSRVYLELKLKSAKIEK*" /label="yvzF CDS" gene complement(2908723..2908908) /gene="yvzF" /locus_tag="BSU_33049" /old_locus_tag="BSU33049" /label="yvzF gene" downshifts 2908912 /Source="Nicolas_upshifts" /id="D1709" /incds=0 /nref=4 /ntot=100 /MaxReadThrough="1.13377" /MaxDrop="4.4478" /score="-3.47814442" /energy="-13.6" /TU="NA" /idTUdmin="U2595" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2908952..2908971) /Source="Nicolas_upshift_promotors" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2908961..2908967 /Source="Nicolas_upshift_promotors" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2908966) /Source="Nicolas_upshifts" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2908981..2908992 /Source="Nicolas_upshift_promotors" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2908984 /Source="Nicolas_upshifts" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2908987..2908990) /Source="Nicolas_upshift_promotors" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2909026..2910474 /gene="gerAA" /locus_tag="BSU_33050" /old_locus_tag="BSU33050" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11418573, 15774895, 16740944, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418573, 15774895, 16740944, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the GerA germination receptor" /protein_id="NP_391185.2" /db_xref="EnsemblGenomes-Gn:BSU33050" /db_xref="EnsemblGenomes-Tr:CAB15295" /db_xref="GOA:P07868" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG10385" /db_xref="UniProtKB/Swiss-Prot:P07868" /translation="MEQTEFKEYIHDNLALVLPKLKENDDLVKNKKMLANGLVFYYLY FSEMTDENKVSEAIKTLIKDEETLTLDQVKKRLDQLDARPVETAKKTIESILNGNCAV FINGLDKAYILTTGKKKTRSLTEPTTEKVVRGPKVAFVEDIDTNLALIRQRTSHPKLI TKKIMIGENKLKPAAIMYIEGKAKKSVIKEVKARLKNIQLEDIQDSGTLEELIEDNKY SPFPQIQNTERPDKVSSALFNGRVAILVDSSPFVLLVPVSLGILMQSPDDYYERWISA SLIRSLRFASIFITLFLSSIYITLVSFHQGLLPTALAVTISANRENVPFPPIFEALLM EVTIELLREAGLRLPNPLGQTIGLVGGVVIGQAAVEANLVSSILVIVVSVIALASFTV PQYGMGLSFRVLRFISMFSAAILGLYGIILFMLVVYTHLTRQTSFGSPYFSPNGFFSL KNTDDSIIRLPIKNKPKEVNNPNEPKTDSTET*" /label="gerAA CDS" gene 2909026..2910474 /gene="gerAA" /locus_tag="BSU_33050" /old_locus_tag="BSU33050" /label="gerAA gene" S_feature complement(2910022..2912665) /Source="Nicolas_S_feature" /locus_tag="new_3391778_3394421_c" /HighExp="Cold, H2O2, G135, G180, Paraq, G150, Oxctl, T-5.40H, LBGstat, T-4.40H" /AntisenseName="gerAC" /AntisenseCor="-9.7163861003102397E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1275" CDS 2910443..2911540 /gene="gerAB" /locus_tag="BSU_33060" /old_locus_tag="BSU33060" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15774895, 15849754, 16740944, 16850406, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15774895, 15849754, 16740944, 16850406, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the germination receptor GerA; putative transporter" /protein_id="NP_391186.1" /db_xref="EnsemblGenomes-Gn:BSU33060" /db_xref="EnsemblGenomes-Tr:CAB15296" /db_xref="GOA:P07869" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG10386" /db_xref="UniProtKB/Swiss-Prot:P07869" /translation="MSQKQTPLKLNTFQGISIVANTMLGAGLLTLPRALTTKANTPDG WITLILEGFIFIFFIYLNTLIQKKHQYPSLFEYLKEGLGKWIGSIIGLLICGYFLGVA SFETRAMAEMVKFFLLERTPIQVIILTFICCGIYLMVGGLSDVSRLFPFYLTVTIIIL LIVFGISFKIFDINNLRPVLGEGLGPIANSLTVVSISFLGMEVMLFLPEHMKKKKYTF RYASLGFLIPIILYILTYIIVVGALTAPEVKTLIWPTISLFQSFELKGIFIERFESFL LVVWIIQFFTTFVIYGYFAANGLKKTFGLSTKTSMVIIGITVFYFSLWPDDANQVMMY SDYLGYIFVSLFLLPFILFFIVALKRRITTK*" /label="gerAB CDS" gene 2910443..2911540 /gene="gerAB" /locus_tag="BSU_33060" /old_locus_tag="BSU33060" /label="gerAB gene" CDS 2911537..2912658 /gene="gerAC" /locus_tag="BSU_33070" /old_locus_tag="BSU33070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11418573, 15774895, 16740944, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418573, 15774895, 16740944, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the germination receptor GerA" /protein_id="NP_391187.1" /db_xref="EnsemblGenomes-Gn:BSU33070" /db_xref="EnsemblGenomes-Tr:CAB15297" /db_xref="GOA:P07870" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG10387" /db_xref="UniProtKB/Swiss-Prot:P07870" /translation="MKIRILCMFICTLLLSGCWDSENIEELSLVIGIGLDKPDDENLE LTQQILVPKIISAKEGSSSDPTQLSITKGKTVHQMMRTSALKHKPTFSQHLRLILLSK SVIADQIGMDAIINQFVRDNGTRRSSYVFITNGRTKDIFNMNDEGEPASNVIYDLTEN NKVTIRTMEPVTLGEISEHLTSDDSFLIPHVGKENGKLAINGASIIKNKLWHRDLTPI EVQNISLFSGTVEGGVIDLKRDGHLFSYEVYSSNRKIKTAYKDGKFKFTVTRNIEGRL SEDWNPNEDSFKDSYIKSIEKTVEKRVHETVTSFITEKLQKEIKADVTGLGNEVRIHY PQKWKKISRKWDDDYFSNAEIDYRVNVIVRDFGTKGANK*" /label="gerAC CDS" gene 2911537..2912658 /gene="gerAC" /locus_tag="BSU_33070" /old_locus_tag="BSU33070" /label="gerAC gene" CDS complement(2912666..2913301) /gene="liaR" /locus_tag="BSU_33080" /old_locus_tag="BSU33080" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YvqE] responding to cell wall stress" /protein_id="NP_391188.1" /db_xref="EnsemblGenomes-Gn:BSU33080" /db_xref="EnsemblGenomes-Tr:CAB15298" /db_xref="GOA:O32197" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14133" /db_xref="UniProtKB/Swiss-Prot:O32197" /translation="MIRVLLIDDHEMVRMGLAAFLEAQPDIEVIGEASDGSEGVRLAV ELSPDVILMDLVMEGMDGIEATKQICRELSDPKIIVLTSFIDDDKVYPVIEAGALSYL LKTSKAAEIADAIRAASKGEPKLESKVAGKVLSRLRHSGENALPHESLTKRELEILCL IAEGKTNKEIGEELFITIKTVKTHITNILSKLDVSDRTQAAVYAHRNHLVN*" /label="liaR CDS" gene complement(2912666..2913301) /gene="liaR" /locus_tag="BSU_33080" /old_locus_tag="BSU33080" /label="liaR gene" CDS complement(2913279..2914361) /gene="liaS" /locus_tag="BSU_33090" /old_locus_tag="BSU33090" /function="16.12: Sense" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LiaR(YvqC)] sensing cell wall stress" /protein_id="NP_391189.1" /db_xref="EnsemblGenomes-Gn:BSU33090" /db_xref="EnsemblGenomes-Tr:CAB15299" /db_xref="GOA:O32198" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR017202" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14134" /db_xref="UniProtKB/Swiss-Prot:O32198" /translation="MRKKMLASLQWRAIRMTTGISLLLFVCLISFMMFYYRLDPLVLL SSSWFGIPFILILLLISVTVGFASGYMYGNRLKTRIDTLIESILTFENGNFAYRIPPL GDDEIGLAADQLNEMAKRVELQVASLQKLSNERAEWQAQMKKSVISEERQRLARDLHD AVSQQLFAISMMTSAVLEHVKDADDKTVKRIRMVEHMAGEAQNEMRALLLHLRPVTLE GKGLKEGLTELLDEFRKKQPIDIEWDIQDTAISKGVEDHLFRIVQEALSNVFRHSKAS KVTVILGIKNSQLRLKVIDNGKGFKMDQVKASSYGLNSMKERASEIGGVAEVISVEGK GTQIEVKVPIFPEEKGENERDSSIID*" /label="liaS CDS" gene complement(2913279..2914361) /gene="liaS" /locus_tag="BSU_33090" /old_locus_tag="BSU33090" /label="liaS gene" CDS complement(2914358..2915083) /gene="liaF" /locus_tag="BSU_33100" /old_locus_tag="BSU33100" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15273097, 15849754, 16816187, 16850406, 17660417, 17921301, 23279150, 23326432" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 15849754, 16816187, 16850406, 17660417, 17921301, 23279150, 23326432; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="membrane component associated to the LiaRS two-component system" /protein_id="NP_391190.1" /db_xref="EnsemblGenomes-Gn:BSU33100" /db_xref="EnsemblGenomes-Tr:CAB15300" /db_xref="GOA:O32199" /db_xref="InterPro:IPR016975" /db_xref="InterPro:IPR024425" /db_xref="SubtiList:BG14135" /db_xref="UniProtKB/Swiss-Prot:O32199" /translation="MTKKQLLGLIIALFGISMFLQIIGIGDLLFWPLFFLIAGYFLKK YSRDWLGSVMYIFAAFLFLKNLFSITFNLFGYAFAAFLIYAGYRLIKGKPIFEPNEKQ VNLNKKEHHEPPKDVKHPDMRSFFIGELQMMKQPFDLNDLNVSGFIGDIKIDLSKAMI PEGESTIVISGVIGNVDIYVPSDLEVAVSSAVFIGDINLIGSKKSGLSTKVYAASTDF SESKRRVKVSVSLFIGDVDVKYV*" /label="liaF CDS" gene complement(2914358..2915083) /gene="liaF" /locus_tag="BSU_33100" /old_locus_tag="BSU33100" /label="liaF gene" CDS complement(2915117..2915989) /gene="liaG" /locus_tag="BSU_33110" /old_locus_tag="BSU33110" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15273097, 16816187, 23326432" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 16816187, 23326432; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="sensor of antibiotic stress on the cell wall" /protein_id="NP_391191.2" /db_xref="EnsemblGenomes-Gn:BSU33110" /db_xref="EnsemblGenomes-Tr:CAB15301" /db_xref="InterPro:IPR025164" /db_xref="SubtiList:BG14136" /db_xref="UniProtKB/Swiss-Prot:O32200" /translation="MKKMLGKLLITAGILVFFAVVVKDVFAAGLGFINGTEADSASAS PRDIDSMVIESDSKDVRIIAEERSDISAGISGDSGKLFVTENKRKLELTVKEKEFQFL NGFNRSTLIVRLPYDYKGDLAVRTSSGDVSVAGNDHLALSGLNAVSASGNTSVTDVRI QDLKVKASSGDVSISNTVSKTAGIDLASGDANLVHVSGSLDVKMTSGDFNAVLKKVTG PVSVTLTSGDANVSLPQNGSFAVNALSASGDVSSPYSFADKGHKEQHHITGTQGSGRH PIDIKTDSGDLAIR*" /label="liaG CDS" gene complement(2915117..2915989) /gene="liaG" /locus_tag="BSU_33110" /old_locus_tag="BSU33110" /label="liaG gene" promotor_-10 complement(2916008..2916027) /Source="Nicolas_upshift_promotors" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2916028) /Source="Nicolas_upshifts" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2916042..2916045) /Source="Nicolas_upshift_promotors" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2916090..2916767) /gene="liaH" /locus_tag="BSU_33120" /old_locus_tag="BSU33120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15273097, 16816187, 23874669, 24666271, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 16816187, 23874669, 24666271, 28546427; Product type f: factor" /codon_start=1 /transl_table=11 /product="modulator of liaIHGFSR (yvqIHGFEC) operon expression" /protein_id="NP_391192.1" /db_xref="EnsemblGenomes-Gn:BSU33120" /db_xref="EnsemblGenomes-Tr:CAB15302" /db_xref="GOA:O32201" /db_xref="InterPro:IPR007157" /db_xref="SubtiList:BG14137" /db_xref="UniProtKB/Swiss-Prot:O32201" /translation="MVLKRIRDMFVASVHEGLDKMENPKVMLNQYVRDMESDIAKAKQ TIVKQHTIAYQFKKKYEEAAEVAGKRKNQAQLAFDAGEEELAKKALTEMKYLEGKAAE HKASYEQANSQLADLKEQLAALETKLQDVKDKKQALIARANAAKAKEHMNTTFDKIDS ESAYREFLRIENRIEEMEIRANYSKSAEAGTELTRKEFADDVEAEIEKMRTLSLQKSD QTKAANE*" /label="liaH CDS" gene complement(2916090..2916767) /gene="liaH" /locus_tag="BSU_33120" /old_locus_tag="BSU33120" /label="liaH gene" downshifts complement(2916106) /Source="Nicolas_upshifts" /id="D1710" /incds=0 /nref=2 /ntot=28 /MaxReadThrough="3.84852" /MaxDrop="3.1352" /score="-8.3477012" /energy="-4.5" /TU="U2597" /idTUdmin="U2598" /TUdmin=1243 /isTUend="FALSE" /label="downshifts" CDS complement(2916794..2917174) /gene="liaI" /locus_tag="BSU_33130" /old_locus_tag="BSU33130" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15273097, 15849754, 16816187, 16850406, 22720735, 24666271, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 15849754, 16816187, 16850406, 22720735, 24666271, 28546427; Product type s: structure" /codon_start=1 /transl_table=11 /product="membrane anchor for the phage-shock protein A homolog LiaH" /protein_id="NP_391193.1" /db_xref="EnsemblGenomes-Gn:BSU33130" /db_xref="EnsemblGenomes-Tr:CAB15303" /db_xref="GOA:O32202" /db_xref="SubtiList:BG14138" /db_xref="UniProtKB/Swiss-Prot:O32202" /translation="MKINKKTIGGFLLIVFGISVFFGGGSFGFIIPLAIGSLMTYAGI KRFAAGKTITGIIVGGIGAIMLICSLPFVVGIALAAAMVYYGWKLMKNGSADNGVSSF DPEPASAAYQSHFDDEWEEFLKKK*" /label="liaI CDS" gene complement(2916794..2917174) /gene="liaI" /locus_tag="BSU_33130" /old_locus_tag="BSU33130" /label="liaI gene" promotor_-10 complement(2917197..2917216) /Source="Nicolas_upshift_promotors" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2917217) /Source="Nicolas_upshifts" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2917231..2917234) /Source="Nicolas_upshift_promotors" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2917336..2918604) /gene="yvqJ" /locus_tag="BSU_33140" /old_locus_tag="BSU33140" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15273097, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux protein" /protein_id="NP_391194.1" /db_xref="EnsemblGenomes-Gn:BSU33140" /db_xref="EnsemblGenomes-Tr:CAB15304" /db_xref="GOA:O32203" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14139" /db_xref="UniProtKB/Swiss-Prot:O32203" /translation="MVNLIESDSIWKRNFNYLFFSRIVKISGDMFAFNSILWFLIYDG KGAIGTALLIAVTFLPEAVLAPVTGPFMKQTTLKFWMYFSDLTRAAIVLIIPLCHFAG FSPLWFVMTLMIVHSATGAAYNPASIALIPQIVNEQGIQKANAVLQSSAQIVRLGAVT LCGAFLTFISPSYTMLIALVLYLVSGFLVLFIKYTAVESQSESAVVTQRGTYIGRLKR GFRLVRKHQILYPLAIYCIFMNFAAAPWEALSAVYVAEDLNGQPIVYSLLKATTAAGA FLLGFVLAKVKVNRYGLLFVTAGIIEGFAFFITGMNTFLPLVFFAAFTFGAAVSAVNV PEYTIIQTSVDSEDQPQVYAVIHMISNISIPAGAVICGYAANAFGSGKVIAVGGIVEI IAGIGILLFTKLAKAERSDLIKEREASVHL*" /label="yvqJ CDS" gene complement(2917336..2918604) /gene="yvqJ" /locus_tag="BSU_33140" /old_locus_tag="BSU33140" /label="yvqJ gene" downshifts complement(2917349) /Source="Nicolas_upshifts" /id="D1711" /incds=0 /nref=78 /ntot=164 /MaxReadThrough="0.70612" /MaxDrop="4.80625" /score="32.7496145" /energy="-12.9" /TU="NA" /idTUdmin="U2598" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2918638..2918657) /Source="Nicolas_upshift_promotors" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2918649) /Source="Nicolas_upshifts" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2918672..2918679) /Source="Nicolas_upshift_promotors" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2918775) /Source="Nicolas_upshifts" /id="D1712" /incds=0 /nref=33 /ntot=211 /MaxReadThrough="1.54601" /MaxDrop="4.92923" /score="51.1311697" /energy="-17.1" /TU="NA" /idTUdmin="U2599" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(2918781..2919362) /gene="yvqK" /locus_tag="BSU_33150" /old_locus_tag="BSU33150" /EC_number="2.5.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12869542, 14704351, 17588214, 19933577, 21514283; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP:cob(I)alamin adenosyltransferase" /protein_id="NP_391195.2" /db_xref="EnsemblGenomes-Gn:BSU33150" /db_xref="EnsemblGenomes-Tr:CAB15305" /db_xref="GOA:O34899" /db_xref="InterPro:IPR016030" /db_xref="InterPro:IPR029499" /db_xref="InterPro:IPR036451" /db_xref="PDB:1RTY" /db_xref="SubtiList:BG14140" /db_xref="UniProtKB/Swiss-Prot:O34899" /translation="MKLYTKTGDKGQTGLVGGRTDKDSLRVESYGTIDELNSFIGLAL AELSGQPGFEDLTAELLTIQHELFDCGGDLAIVTERKDYKLTEESVSFLETRIDAYTA EAPELKKFILPGGSKCASLLHIARTITRRAERRVVALMKSEEIHETVLRYLNRLSDYF FAAARVVNARSGIGDVEYERSAIVFRDRNSSES*" /label="yvqK CDS" gene complement(2918781..2919362) /gene="yvqK" /locus_tag="BSU_33150" /old_locus_tag="BSU33150" /label="yvqK gene" CDS complement(2919385..2920713) /gene="yvrA" /locus_tag="BSU_33160" /old_locus_tag="BSU33160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative vitamin B12 transport system, ATPase component" /protein_id="NP_391196.1" /db_xref="EnsemblGenomes-Gn:BSU33160" /db_xref="EnsemblGenomes-Tr:CAB15306" /db_xref="GOA:O34631" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14141" /db_xref="UniProtKB/Swiss-Prot:O34631" /translation="MKAEGLSGGYGDSRLINNVSLTVEKGEFLGILGPNGSGKTTLLH LLTGTLPAKKGRVYLAGKLLADYKPKELAQIMAVLPQKMDQAFTFTVEETVAFGRYPF QTGLFRQQTEKGEAIVQEAMEQTGVADFAQKPIRELSGGEQQRVYLAQALAQQPRILF LDEPTNFLDLAYQKDLLDLIKRLTRESGLAAVSVFHDLNTASLYCDGLMFMKNGTAGP KQKPEYAVTEQSIKAVYDTDVTALVHQSSPKPMIVIQPEKDSVKRQSIPFEALLQAGR DDILLQTEIPLRTLSSTPIGAGFSWSRTLIHKRLPDQPDPIEGLTACLSESGFQLQET CAMASSERLDRFVYRTYEDGELSVFICVQTGFSIWILINGYAADQFFIKALMAAEAER TKVLGDGGGTGDILIAATQTQQSENIEQRLNQLIKKGTAECIKEAAELFE*" /label="yvrA CDS" gene complement(2919385..2920713) /gene="yvrA" /locus_tag="BSU_33160" /old_locus_tag="BSU33160" /label="yvrA gene" CDS complement(2920713..2921774) /gene="yvrB" /locus_tag="BSU_33170" /old_locus_tag="BSU33170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 15849754, 16850406, 25917914; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative vitamin B12 permease" /protein_id="NP_391197.1" /db_xref="EnsemblGenomes-Gn:BSU33170" /db_xref="EnsemblGenomes-Tr:CAB15307" /db_xref="GOA:O34451" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG14142" /db_xref="UniProtKB/Swiss-Prot:O34451" /translation="MRKAFTRIRLRNNRYAAYIIGFSFLAVSIILGISCGSLHIPIPA VFRVFWHQGFGGSIGSDDPMYTNIMMNIRLPRVVLAALVGAALSIAGAAFQGLLKNPL ADPYTLGVSSGASVGAVVTLFLGLHLPVIGGFTLPVLSVAAALATMAAVLFFSRLVHA SMSVSTLILTGVITNSFLGAFISLIIALTGDNLLPIVHWLLGSVSMRGWSYVILFLPF FLLGTILLIINGRELNVMTYGEDKAKLLGVSVQQRKMMILIAGSLLTGSAVAVSGTIG FVGLVIPHITRLLWGTDHRHLLPLSALLGAGFLVLADLLSRTIIEPIELPIGIITSLA GAPVFALILIRQHRGGRSL*" /label="yvrB CDS" gene complement(2920713..2921774) /gene="yvrB" /locus_tag="BSU_33170" /old_locus_tag="BSU33170" /label="yvrB gene" CDS complement(2921737..2922681) /gene="yvrC" /locus_tag="BSU_33180" /old_locus_tag="BSU33180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 25917914; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative lipoprotein binding vitamin B12" /protein_id="NP_391198.1" /db_xref="EnsemblGenomes-Gn:BSU33180" /db_xref="EnsemblGenomes-Tr:CAB15308" /db_xref="GOA:O34805" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG14143" /db_xref="UniProtKB/Swiss-Prot:O34805" /translation="MKKRAGIWAALLLAAVMLAGCGNPADQKDSKAKQKTEVFPVTID DASNQDVTIKKEPKKIVSLMPSNTEITYALGLGDKVVGVTTNDTYPKEVKKVEKVGDM NVNVEKVISLKPDLVLAHESSMSASADAIKQLKDAGITVLTVNDAQSFSEVYKSIEMI GEAGGAEKKADQLVKSMKSDLKDIQEKAKTISKDEEKSVFIEVSPDPDIYTTGKDTFM NEMLNVIHAKNAAADQTGWVQMTDEAIVKLNPDAIVTTDGVKAKAVEKRDGWSEINAV KHHRVYDVDPDLVTRSGPRLIEGVEELAESIYPDTFKE*" /label="yvrC CDS" gene complement(2921737..2922681) /gene="yvrC" /locus_tag="BSU_33180" /old_locus_tag="BSU33180" /label="yvrC gene" S_feature complement(2922682..2922951) /Source="Nicolas_S_feature" /locus_tag="new_3404438_3404707_c" /HighExp="LBGtran, LBGexp, Etha, LPh, S3, Lbexp, G180, dia0, HPh, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.956, 1" /TUlongSig="SigA" /TUlongPSig="0.925" /label="S1276" misc_RNA complement(2922790..2922920) /gene="srbL" /locus_tag="BSU_misc_RNA_85" /product="putative coenzyme B12 (AdoCbl) riboswitch" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 17038623, 21140903, 25917914; Product type n: RNA" /function="16.3: Control" /label="srbL RNA" gene complement(2922790..2922920) /gene="srbL" /locus_tag="BSU_misc_RNA_85" /label="srbL gene" promotor_-10 complement(2922928..2922947) /Source="Nicolas_upshift_promotors" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2922951) /Source="Nicolas_upshifts" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2922953..2923880) /Source="Nicolas_S_feature" /locus_tag="new_3404709_3405636_c" /HighExp="Etha, B60, Sw, M9-stat, B36, C30, C90, Salt, G135, Gly" /AntisenseName="yvrD" /AntisenseCor="1.5286196477289399E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.925" /label="S1277" promotor_-35 complement(2922963..2922970) /Source="Nicolas_upshift_promotors" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2923013..2923020 /Source="Nicolas_upshift_promotors" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2923035..2923054 /Source="Nicolas_upshift_promotors" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2923039 /Source="Nicolas_upshifts" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="upshifts" CDS 2923079..2923870 /gene="yvrD" /locus_tag="BSU_33190" /old_locus_tag="BSU33190" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9922248; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391199.1" /db_xref="EnsemblGenomes-Gn:BSU33190" /db_xref="EnsemblGenomes-Tr:CAB15309" /db_xref="GOA:O34782" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14144" /db_xref="UniProtKB/Swiss-Prot:O34782" /translation="MDLQLKEKLVLITGSTSGIGKAAAKSFLQEGAAVIVNGRKQETV DRTIEELSGYGTVHGAAADLSKTDEAAAFIEKVNEIGDIDILVNNLGFFEVKDFADVT DEEWNQYFEVNVMSAVRTSRHFLPKMLAKNSGRILNIASEAGVKPLPTMIPYSMTKTA LISLSRGMAEMTKGTNVTVNSVLPGPTWTEGVASYMEGAAQAAGQDTDTFIKDYFKVN EPTSLIQRYATAEEVANTIVFLASDAASAINGTAQRVEGGIIRSL*" /label="yvrD CDS" gene 2923079..2923870 /gene="yvrD" /locus_tag="BSU_33190" /old_locus_tag="BSU33190" /label="yvrD gene" downshifts 2923741 /Source="Nicolas_upshifts" /id="D1713" /incds=1 /nref=2 /ntot=89 /MaxReadThrough="6.202" /MaxDrop="3.35017" /score="36.8938178" /energy="-12" /TU="U2600" /idTUdmin="U2600" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 2923851 /Source="Nicolas_upshifts" /id="D1714" /incds=0 /nref=105 /ntot=218 /MaxReadThrough="2.44739" /MaxDrop="6.33457" /score="36.8938178" /energy="-12" /TU="NA" /idTUdmin="U2600" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2923908..2924786) /gene="yvrE" /locus_tag="BSU_33200" /old_locus_tag="BSU33200" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar lactone lactonase" /protein_id="NP_391200.1" /db_xref="EnsemblGenomes-Gn:BSU33200" /db_xref="EnsemblGenomes-Tr:CAB15310" /db_xref="GOA:O34940" /db_xref="InterPro:IPR005511" /db_xref="InterPro:IPR011042" /db_xref="InterPro:IPR013658" /db_xref="SubtiList:BG14145" /db_xref="UniProtKB/Swiss-Prot:O34940" /translation="MDAVLEADTRAVIGEGPLWDEENGRLYWVDILGSELHIFDPEEK INRSIKFKSFVTALAKYSKDELIMTMKDGFYLYHLRDDSLEKIKQPKDMHESLRFNDA KCDPYGRLWAGTTSMEGEQKQASLYRLNLDGSLVKIKDQVSTSNGLDWDRERNLMYYI DTPTQEIVRYSYDPQSGDVSNPEPVYRFDQSDGLPDGMTIDQNGMLWVALFGGSRVVH IDPFQKKEINSISVPAKYVTCCAFGGRDLKTLYITTATEQMTEKERYEQPHAGGLFSA QLETGGYQPVPFAGDV*" /label="yvrE CDS" gene complement(2923908..2924786) /gene="yvrE" /locus_tag="BSU_33200" /old_locus_tag="BSU33200" /label="yvrE gene" downshifts complement(2923925) /Source="Nicolas_upshifts" /id="D1715" /incds=0 /nref=31 /ntot=260 /MaxReadThrough="7.17016" /MaxDrop="5.74101" /score="29.8014794" /energy="-12" /TU="U2601" /idTUdmin="U2602" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2924810..2924828) /Source="Nicolas_upshift_promotors" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2924829) /Source="Nicolas_upshifts" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2924842..2924848) /Source="Nicolas_upshift_promotors" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2924858..2926600) /gene="yvrG" /locus_tag="BSU_33210" /old_locus_tag="BSU33210" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 16306698, 25879813" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16306698, 25879813; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase YvrG [cellwall processes and sublancin production and immunity(YvrH)]" /protein_id="NP_391201.2" /db_xref="EnsemblGenomes-Gn:BSU33210" /db_xref="EnsemblGenomes-Tr:CAB15311" /db_xref="GOA:O34989" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14146" /db_xref="UniProtKB/Swiss-Prot:O34989" /translation="MRLRWKFLFHFFGQMLIVILLLTVMLVASFFYLDARFSDAESNS GLTKATTDTLEAYLDVNEDGTWEVDNFLKKSVDKQHGWMQIIDSEGNTDYSYGVPKDV PGTYTKKELLSIYKTKKLHNYKLNYWAINIEDKSYLLLSGWKSKSEQLLTSVEKREQK IDSLAHYKSSTIDYIKRKKGAIYLLDSNGKILDSINSTKSERKTMNQLELLKYSSKPW NYKREISVKILNKDRWMVATVPNPVYVTDQEFNKSFLKVVLKAMFLVMAVLFMYIIWM TVWYMFRFGLPIFHTIRWLVNLSKGKLEEPRNREGRPVSKNKKGKIKQPYRFFGEIFE SMDQLTETLRRDKRNREKIQATREEWIAGLSHDLKTPLSSIYGYSMMLESKQYDWSPE EVKEMGQVVREKSEYMSKLIEDLNLTYRLKNDALPIERKLTSLIPFFKNVIEDFKKNP FSEGYDISFVSKEEHIEFALDEAWFRRILENLLGNAVKHNGKGTEIQVILEQTKNHIS LKVKDNGKGMDEETITHLFNRYYRGTNTKDSTAGTGLGLAIAKELVHLHNGTIHVNSR TNIGTVITILFKKQ*" /label="yvrG CDS" gene complement(2924858..2926600) /gene="yvrG" /locus_tag="BSU_33210" /old_locus_tag="BSU33210" /label="yvrG gene" CDS complement(2926597..2927310) /gene="yvrH" /locus_tag="BSU_33221" /old_locus_tag="BSU33221" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 16306698, 25879813" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16306698, 25879813; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase YvrG [cellwall processes and sublancin production and immunity(YvrG)]" /protein_id="NP_391202.2" /db_xref="EnsemblGenomes-Gn:BSU33221" /db_xref="EnsemblGenomes-Tr:CAB15312" /db_xref="GOA:P94504" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12452" /db_xref="UniProtKB/Swiss-Prot:P94504" /translation="MENASILIVDDEKAIVDMIKRVLEKEGYRNILDAASAEEAIPVV KANKVDLIVLDVMMGGMSGFEACTLIREYSDAPIFFLTARSSDADKLSGFAVGADDYI TKPFNPLELAARIRAHLKRTYQSKETSSNQTYTYDYFTFSPQNAELIVGGEAVACSAQ LLQLLQYFCEHPNVVLSKDQIYEKVWGYPSYGDNNTVMVHIRKLREKIERDPSNPEYI VTVRGLGYRFIPNPEGKRS*" /label="yvrH CDS" gene complement(2926597..2927310) /gene="yvrH" /locus_tag="BSU_33221" /old_locus_tag="BSU33221" /label="yvrH gene" misc_feature complement(2927341..2927360) /Source="Nicolas_upshift_promotors" /id="U2602" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.629370629370629" /psig="0.925074925074925" /xcortree=2348 /SigmaFactorBS="ccttttttgctgttttgatttgccaaggctccaatgtattca aaaatgtaccataaataAACGATATAATGATAAGATGaaaaaaacagtgacagaaagg a" /listShort="yvrH, yvrG, yvrE" /listLong="S1277, S1276, yvrC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2927359) /Source="Nicolas_upshifts" /id="U2602" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.629370629370629" /psig="0.925074925074925" /xcortree=2348 /SigmaFactorBS="ccttttttgctgttttgatttgccaaggctccaatgtattca aaaatgtaccataaataAACGATATAATGATAAGATGaaaaaaacagtgacagaaagg a" /listShort="yvrH, yvrG, yvrE" /listLong="S1277, S1276, yvrC" /label="upshifts" CDS complement(2927463..2927702) /gene="rsoA" /locus_tag="BSU_33222" /old_locus_tag="BSU33222" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18573182, 19047353, 27558998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18573182, 19047353, 27558998; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of sigma-O" /protein_id="YP_003097787.1" /db_xref="EnsemblGenomes-Gn:BSU33222" /db_xref="EnsemblGenomes-Tr:CAX52693" /db_xref="GOA:C0H3R4" /db_xref="UniProtKB/Swiss-Prot:C0H3R4" /translation="MDGQFEQKKKQKDETYDIEHLIACFSPMIRKKLSNTSYQEREDL EQELKIKMFEKADMLLCQDVPGFWEFILYMVDENS*" /label="rsoA CDS" gene complement(2927463..2927702) /gene="rsoA" /locus_tag="BSU_33222" /old_locus_tag="BSU33222" /label="rsoA gene" downshifts complement(2927470) /Source="Nicolas_upshifts" /id="D1716" /incds=0 /nref=4 /ntot=30 /MaxReadThrough="2.45068" /MaxDrop="3.82244" /score="12.6471586" /energy="-8.2" /TU="NA" /idTUdmin="U2605" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2927698..2927716) /Source="Nicolas_upshift_promotors" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2927706..2928236) /gene="sigO" /locus_tag="BSU_33230" /old_locus_tag="BSU33230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16306698, 18573182, 19047353, 27558998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16306698, 18573182, 19047353, 27558998; Product type r: regulator" /codon_start=1 /transl_table=11 /product="alternative sigma factor" /protein_id="NP_391203.2" /db_xref="EnsemblGenomes-Gn:BSU33230" /db_xref="EnsemblGenomes-Tr:CAB15313" /db_xref="GOA:O34843" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14147" /db_xref="UniProtKB/Swiss-Prot:O34843" /translation="MKHPIVKHFLSNPQHYRLFKNVMESPNEKDARSLDELFKQFYKE IRIVKYMNSMIRIFSIDFDKRVRKNQKRYPLTVDHPEAGDRLSSETGSDAFEEFLDRQ DDLSQHVQDYQLYQAIQKLTDKQKSVLTKVYLHGATMQEIADSLGESRQNISNIHKKG LENIRKQLAAQKKGEK*" /label="sigO CDS" gene complement(2927706..2928236) /gene="sigO" /locus_tag="BSU_33230" /old_locus_tag="BSU33230" /label="sigO gene" upshifts complement(2927707) /Source="Nicolas_upshifts" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2927731..2927737) /Source="Nicolas_upshift_promotors" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2928239..2928258) /Source="Nicolas_upshift_promotors" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2928246) /Source="Nicolas_upshifts" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="upshifts" CDS 2928251..2928589 /gene="yvrJ" /locus_tag="BSU_33239" /old_locus_tag="BSU33239" /experiment="publication(s) with functional evidences, PMID:18573182, 19047353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18573182, 19047353; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in oxalate decarboxylase expression" /protein_id="YP_003097788.1" /db_xref="EnsemblGenomes-Gn:BSU33239" /db_xref="EnsemblGenomes-Tr:CAX52694" /db_xref="InterPro:IPR024419" /db_xref="UniProtKB/Swiss-Prot:C0H3R5" /translation="MTVKDFDSPSNRLPTKLNEGKQKKVNYYFPPSVFQNTLQQFTFY RFSSLTYMTAEKEGRYFPMDQVFIEEVVKQIGNLGFPALIAMYLLTRFEKKFDQLIEL MTELKDHAKK*" /label="yvrJ CDS" gene 2928251..2928589 /gene="yvrJ" /locus_tag="BSU_33239" /old_locus_tag="BSU33239" /label="yvrJ gene" promotor_-35 complement(2928273..2928280) /Source="Nicolas_upshift_promotors" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2928289..2928308) /Source="Nicolas_upshift_promotors" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2928301) /Source="Nicolas_upshifts" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2928323..2928329) /Source="Nicolas_upshift_promotors" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2928335..2928435 /Source="Nicolas_upshift_promotors" /id="U2606" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.277722277722278" /xcortree=389 /SigmaFactorBS="tttccgcctagtgtcttccaaaatactttgcagcagtttacg ttttatcggttttcctcacttacatacatgactgcagaaaaagaagggaggtattttc c" /GFF_Attribute="listShort" /listLong="S1278, oxdC, yvrL" /label="promotor_no_box" upshifts 2928395 /Source="Nicolas_upshifts" /id="U2606" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.277722277722278" /xcortree=389 /SigmaFactorBS="tttccgcctagtgtcttccaaaatactttgcagcagtttacg ttttatcggttttcctcacttacatacatgactgcagaaaaagaagggaggtattttc c" /GFF_Attribute="listShort" /listLong="S1278, oxdC, yvrL" /label="upshifts" promotor_no_box 2928563..2928663 /Source="Nicolas_upshift_promotors" /id="U2607" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.316683316683317" /xcortree=387 /SigmaFactorBS="gaactgaaagatcatgcaaaaaaataatttttcaatcgaagt tgacttttcactggtttttttcacttaacaaaacagaagggaaaacgaaaggcctttc a" /listShort="S1278, oxdC, yvrL" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 2928623..2928709 /Source="Nicolas_S_feature" /locus_tag="new_3410379_3410465" /HighExp="T5.0H, T4.0H, T3.30H, Lbstat, T3.0H, nit, T2.0H, T2.30H, LPhT, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.317" /TUlongSig="Sig-" /TUlongPSig="0.278" /label="S1278" upshifts 2928623 /Source="Nicolas_upshifts" /id="U2607" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.316683316683317" /xcortree=387 /SigmaFactorBS="gaactgaaagatcatgcaaaaaaataatttttcaatcgaagt tgacttttcactggtttttttcacttaacaaaacagaagggaaaacgaaaggcctttc a" /listShort="S1278, oxdC, yvrL" /GFF_Attribute="listLong" /label="upshifts" CDS 2928710..2929867 /gene="oxdC" /locus_tag="BSU_33240" /old_locus_tag="BSU33240" /EC_number="4.1.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10960116, 14697267, 14871895, 17459326, 18573182, 19047353, 21255608, 21264418, 21782782, 26744902, 27797181" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10960116, 14697267, 14871895, 17459326, 18573182, 19047353, 21255608, 21264418, 21782782, 26744902, 27797181; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="oxalate decarboxylase" /protein_id="NP_391204.1" /db_xref="EnsemblGenomes-Gn:BSU33240" /db_xref="EnsemblGenomes-Tr:CAB15314" /db_xref="GOA:O34714" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR017774" /db_xref="PDB:1J58" /db_xref="PDB:1L3J" /db_xref="PDB:1UW8" /db_xref="PDB:2UY8" /db_xref="PDB:2UY9" /db_xref="PDB:2UYA" /db_xref="PDB:2UYB" /db_xref="PDB:2V09" /db_xref="PDB:3S0M" /db_xref="PDB:4MET" /db_xref="PDB:5HI0" /db_xref="SubtiList:BG14148" /db_xref="UniProtKB/Swiss-Prot:O34714" /translation="MKKQNDIPQPIRGDKGATVKIPRNIERDRQNPDMLVPPETDHGT VSNMKFSFSDTHNRLEKGGYAREVTVRELPISENLASVNMRLKPGAIRELHWHKEAEW AYMIYGSARVTIVDEKGRSFIDDVGEGDLWYFPSGLPHSIQALEEGAEFLLVFDDGSF SENSTFQLTDWLAHTPKEVIAANFGVTKEEISNLPGKEKYIFENQLPGSLKDDIVEGP NGEVPYPFTYRLLEQEPIESEGGKVYIADSTNFKVSKTIASALVTVEPGAMRELHWHP NTHEWQYYISGKARMTVFASDGHARTFNYQAGDVGYVPFAMGHYVENIGDEPLVFLEI FKDDHYADVSLNQWLAMLPETFVQAHLDLGKDFTDVLSKEKHPVVKKKCSK*" /label="oxdC CDS" gene 2928710..2929867 /gene="oxdC" /locus_tag="BSU_33240" /old_locus_tag="BSU33240" /label="oxdC gene" downshifts 2929853 /Source="Nicolas_upshifts" /id="D1717" /incds=0 /nref=11 /ntot=87 /MaxReadThrough="4.83038" /MaxDrop="4.39135" /score="2.61432951" /energy="-9.4" /TU="U2607" /idTUdmin="U2607" /TUdmin="-484" /isTUend="FALSE" /label="downshifts" CDS 2929928..2930338 /gene="rsiO" /locus_tag="BSU_33250" /old_locus_tag="BSU33250" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18573182, 19047353, 26651345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18573182, 19047353, 26651345; Product type f: factor" /codon_start=1 /transl_table=11 /product="acid stress-sensitive anti sigma factor" /protein_id="NP_391205.1" /db_xref="EnsemblGenomes-Gn:BSU33250" /db_xref="EnsemblGenomes-Tr:CAB15315" /db_xref="GOA:O34686" /db_xref="InterPro:IPR025912" /db_xref="SubtiList:BG14149" /db_xref="UniProtKB/Swiss-Prot:O34686" /translation="MKHQNPSKRLLRLSIKYLLAAAAVVLTYFAVIYILFSLAGTSYR SAAHVLLFAVVFLVLGLCFEPFERLMIHSFTFFKTGKRLFILLAGIVQLLFLWMTAHT TDQLISDIWLSTTEEMIVAAVFLILDKCNSALPS*" /label="rsiO CDS" gene 2929928..2930338 /gene="rsiO" /locus_tag="BSU_33250" /old_locus_tag="BSU33250" /label="rsiO gene" downshifts 2930337 /Source="Nicolas_upshifts" /id="D1718" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="0.57216" /MaxDrop="3.72691" /score="-9.50136752" /energy="-7.4" /TU="NA" /idTUdmin="U2607" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2930372..2931601) /gene="yvrN" /locus_tag="BSU_33260" /old_locus_tag="BSU33260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_391207.3" /db_xref="EnsemblGenomes-Gn:BSU33260" /db_xref="EnsemblGenomes-Tr:CAB15317" /db_xref="GOA:P46324" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG11368" /db_xref="UniProtKB/Swiss-Prot:P46324" /translation="MLEHIRISFQSIFSHKLRSILTMLGVIIGIAAIIAIVSMLKGQS EQLKQSMIGMGNNAINVVYQPSGGEEESGGPQVSYASAPPVAEETVKAIKSDPMVKGL SLYYLSEGASVFHLTNVSYPQVYGVDDDYFDMFPIRITEGRKLTENDLNSTHQVVMIN EAVRDELFPDGEALHKSIEMNGVPFKVVGVFKEKNQQESMFEGDYANPVLYVPKKVWP LIEGFDAPTQIAVQADSSEHIQEAGVMAADLLNQGLSEAELEKAEYSVMDLQEIAQEV ESFNQSFALLLGGIASISLLVGGIGVMNIMLVSVTERTREIGIKKALGAKRRVILFQF LTEAVVLTSIGGILGVLAGFGIAKLLTVIFPMPFIVSIPAVVGALIFSMAVGIIFGLL PSIKASKLQPVDALRYE*" /label="yvrN CDS" gene complement(2930372..2931601) /gene="yvrN" /locus_tag="BSU_33260" /old_locus_tag="BSU33260" /label="yvrN gene" downshifts complement(2930389) /Source="Nicolas_upshifts" /id="D1719" /incds=0 /nref=10 /ntot=218 /MaxReadThrough="2.36812" /MaxDrop="4.29282" /score="13.74435" /energy="-11.3" /TU="NA" /idTUdmin="U2608" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" CDS complement(2931594..2932283) /gene="yvrO" /locus_tag="BSU_33270" /old_locus_tag="BSU33270" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544226, 22517742; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_391208.2" /db_xref="EnsemblGenomes-Gn:BSU33270" /db_xref="EnsemblGenomes-Tr:CAB15318" /db_xref="GOA:O34979" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14151" /db_xref="UniProtKB/Swiss-Prot:O34979" /translation="MLTLNNISKSYKLGKEEVPILKHINLTVQAGEFLAIMGPSGSGK STLMNIIGCLDRPTSGTYTLDQIDILKGKDGALAEIRNESIGFVFQTFHLLPRLTALQ NVELPMIYNKVKKKERRQRAYEALEKVGLKDRVSYKPPKLSGGQKQRVAIARALVNQP RFILADEPTGALDTKSSEQILALFSELHREGKTIIMITHDPDVAKKADRTVFIRDGEL VLDERGDISHA*" /label="yvrO CDS" gene complement(2931594..2932283) /gene="yvrO" /locus_tag="BSU_33270" /old_locus_tag="BSU33270" /label="yvrO gene" CDS complement(2932267..2933460) /gene="yvrP" /locus_tag="BSU_33280" /old_locus_tag="BSU33280" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter membrane fusion component" /protein_id="NP_391209.1" /db_xref="EnsemblGenomes-Gn:BSU33280" /db_xref="EnsemblGenomes-Tr:CAB15319" /db_xref="GOA:O35007" /db_xref="InterPro:IPR032317" /db_xref="SubtiList:BG14152" /db_xref="UniProtKB/Swiss-Prot:O35007" /translation="MSKKKKWLIGGAICAGVLVLAGIGAGGFYFFTHMNQVAVSSEPY AESVAVYMGGDSESGQTFSGKVEPEKQQKVYIDSEKGSIKKTYVKEGDQVKKGDKLFE YEGEDHSDEVEQANLQIEMTNLQINRLQKSITETEKKLKVAGKEEKNQLQDELDQTNF DLKTSQLELKQHQKELAGLTKNKGSNVITSKHDGIVQSVNQDIADGATGDQAAGPYIQ IVSTGKYLVKSQINELLMDTIKKGSKVRVTLKTGGEGEWKGKVTSIGKLPAGAGEGEE SESFADEEMNPQSSNYPFTILLDSHKGLEVGYHVNIEVMSDNADADTIKLPSDMVIQD DGEPYVWKADENHKAVKQPVEIGETDENDMVEIKSGLTPEDYVIYPDPAVKEGKQVTV NADTE*" /label="yvrP CDS" gene complement(2932267..2933460) /gene="yvrP" /locus_tag="BSU_33280" /old_locus_tag="BSU33280" /label="yvrP gene" promotor_-10 complement(2933504..2933523) /Source="Nicolas_upshift_promotors" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2933517) /Source="Nicolas_upshifts" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2933538..2933545) /Source="Nicolas_upshift_promotors" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2933631..2934440) /gene="fhuC" /locus_tag="BSU_33290" /old_locus_tag="BSU33290" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 8596459, 10913070, 15802251; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (ATP-binding protein)" /protein_id="NP_391210.1" /db_xref="EnsemblGenomes-Gn:BSU33290" /db_xref="EnsemblGenomes-Tr:CAB15335" /db_xref="GOA:P49938" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11390" /db_xref="UniProtKB/Swiss-Prot:P49938" /translation="MNSLSTEQLGIGYGDRVIVEDLNISIPKGKITTLIGPNGCGKST ILKTMSRIMRSHAGAVYLNGKAIHKMSTKDIAKDMAILPQTPEAPSGLTVHELVSYGR FPHQSGFGRLNDEDRRIIKWALEETGMAEYAERPIEALSGGQRQRVWIAMALAQGTEL LLLDEPTTYLDLAHQLEILQLLDRLNKEQGRTILMVIHDLNHAARFSHYMIALKKGTV IKEGTALEVMTPDILKQVFQIDAEIVTDPRTNKPVCLTYDLIKNEKELVTV*" /label="fhuC CDS" gene complement(2933631..2934440) /gene="fhuC" /locus_tag="BSU_33290" /old_locus_tag="BSU33290" /label="fhuC gene" downshifts complement(2933648) /Source="Nicolas_upshifts" /id="D1720" /incds=0 /nref=190 /ntot=245 /MaxReadThrough="1.31294" /MaxDrop="6.48454" /score="40.5986253" /energy="-11" /TU="NA" /idTUdmin="U2610" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2933787..2933796 /Source="Nicolas_upshift_promotors" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2933809..2933828 /Source="Nicolas_upshift_promotors" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2933813 /Source="Nicolas_upshifts" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2934456..2935466) /gene="fhuG" /locus_tag="BSU_33300" /old_locus_tag="BSU33300" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 8596459, 10913070, 15802251, 15849754, 16850406, 24362930; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (permease)" /protein_id="NP_391211.1" /db_xref="EnsemblGenomes-Gn:BSU33300" /db_xref="EnsemblGenomes-Tr:CAB15336" /db_xref="GOA:P49937" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG11391" /db_xref="UniProtKB/Swiss-Prot:P49937" /translation="MKTKTNKPLIVMAVTFLLIVVVFFISLNLGVIKIAPLKTLQVFF GQGTARDELVLFEFRLPRIILSLLVGAGISVAGAILQSVSQNELAEPGILGINAGGSL AVVLFIYFFQGSASDLSFFGTFMLPFSALAGAILAAFLIYILAWKKGVTPIRLILVGI GVNAGFNALLLIFQLKMDPHDFMQAAVWISGSIWGANWNMIWAILPWIVILLLFTLYK ARYLNIMQLGDQLATGLGTAVEKERRILLLAAVTLAASCVAAAGGIAFLGLIAPHVAR RLTGPRHQTLIPVSAFIGSFLFLLADTLARNVLAPSEIPVGLVISVLGAPYFIYLLMK AN*" /label="fhuG CDS" gene complement(2934456..2935466) /gene="fhuG" /locus_tag="BSU_33300" /old_locus_tag="BSU33300" /label="fhuG gene" CDS complement(2935466..2936620) /gene="fhuB" /locus_tag="BSU_33310" /old_locus_tag="BSU33310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 12354229, 15849754, 16850406, 24362930; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (permease)" /protein_id="NP_391212.1" /db_xref="EnsemblGenomes-Gn:BSU33310" /db_xref="EnsemblGenomes-Tr:CAB15337" /db_xref="GOA:P49936" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG11389" /db_xref="UniProtKB/Swiss-Prot:P49936" /translation="MHFHFCSKHSIKSAEKSDILKQQLIIIISNRKEVRQLSQHKNIR TASEEIQWTSRTYGAVIVLIAGLCLLCLGAFLSISLGAADIHLRTVWEAIFHYQPTKT SHQIIHDLRLPRTAAAALVGALLAVSGAIMQGMTRNPLAEPSIMGVTSGSAFAVSIAF AFFPGLSAMGLVLWSFAGAGLGASTVMGIGMFSRGGLTPVKLALAGTAVTYFFTGIST AIAIRFDVAQDISFWYAGGVAGVKWSGVQLLLIAGAVGLTLAFFIARSVTVLSLGDDL AKGLGQYTSAVKLVGMLIVVILTGAAVSIAGTIAFIGLIIPHITRFLVGVDYRWIIPC SAVLGAVLLVFADIAARLVNAPFETPVGALTSLIGVPFFFYLARRERRGL*" /label="fhuB CDS" gene complement(2935466..2936620) /gene="fhuB" /locus_tag="BSU_33310" /old_locus_tag="BSU33310" /label="fhuB gene" promotor_-10 complement(2936553..2936572) /Source="Nicolas_upshift_promotors" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2936570) /Source="Nicolas_upshifts" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2936584..2936591) /Source="Nicolas_upshift_promotors" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2936632..2936639 /Source="Nicolas_upshift_promotors" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2936654..2936673 /Source="Nicolas_upshift_promotors" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2936663 /Source="Nicolas_upshifts" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="upshifts" CDS 2936718..2937665 /gene="fhuD" /locus_tag="BSU_33320" /old_locus_tag="BSU33320" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 12354229, 26919525; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (ferrichrome-bindinglipoprotein)" /protein_id="NP_391213.1" /db_xref="EnsemblGenomes-Gn:BSU33320" /db_xref="EnsemblGenomes-Tr:CAB15338" /db_xref="GOA:P37580" /db_xref="InterPro:IPR002491" /db_xref="PDB:3G9Q" /db_xref="PDB:3HXP" /db_xref="SubtiList:BG10828" /db_xref="UniProtKB/Swiss-Prot:P37580" /translation="MTHIYKKLGAAFFALLLIAALAACGNNSESKGSASDSKGAETFT YKAENGNVKIPKHPKRVVVMADGYYGYFKTLGINVVGAPENVFKNPYYKGKTNGVENI GDGTSVEKVIDLNPDLIIVWTTQGADIKKLEKIAPTVAVKYDKLDNIEQLKEFAKMTG TEDKAEKWLAKWDKKVAAAKTKIKKAVGDKTISIMQTNGKDIYVFGKDFGRGGSIIYK DLGLQATKLTKEKAIDQGPGYTSISLEKLPDFAGDYIFAGPWQSGGDDGGVFESSIWK NLNAVKNGHVYKMDPIGFYFTDPISLEGQLEFITESLTK*" /label="fhuD CDS" gene 2936718..2937665 /gene="fhuD" /locus_tag="BSU_33320" /old_locus_tag="BSU33320" /label="fhuD gene" downshifts 2937641 /Source="Nicolas_upshifts" /id="D1721" /incds=0 /nref=168 /ntot=245 /MaxReadThrough="3.82329" /MaxDrop="5.73183" /score="11.0136807" /energy="-12.1" /TU="U2611" /idTUdmin="U2611" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts 2937685 /Source="Nicolas_upshifts" /id="D1722" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="3.01143" /MaxDrop="4.08479" /score="11.0136807" /energy="-12.1" /TU="NA" /idTUdmin="U2611" /TUdmin=22 /isTUend="TRUE" /label="downshifts" downshifts 2937839 /Source="Nicolas_upshifts" /id="D1723" /incds=0 /nref=8 /ntot=87 /MaxReadThrough="0.219110000000001" /MaxDrop="3.67928" /score="7.53231618" /energy="-13.7" /TU="NA" /idTUdmin="U2611" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS complement(2937900..2939309) /gene="lysP" /locus_tag="BSU_33330" /old_locus_tag="BSU33330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14627808, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lysine permease" /protein_id="NP_391214.1" /db_xref="EnsemblGenomes-Gn:BSU33330" /db_xref="EnsemblGenomes-Tr:CAB15339" /db_xref="GOA:O32204" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG14154" /db_xref="UniProtKB/Swiss-Prot:O32204" /translation="MEQTKKWGFWLLTAFVVGNMVGSGIFSLPSSLASIASPFGATSA WLLTGAGVLMIALVFGHLSIRKPELTAGPQSYARALFSDPKKGNAAGFTMVWGYWVAS WISNVAIITSLAGYLTSFFPILVDKREMFSIGGQEVTLGQLLTFAVCTILLWGTHAIL VASINGASKLNFVTTLSKVLGFVFFIVAGLFVFQTSLFGHFYFPVQGENGTSIGIGGQ VHNAAISTLWAFVGIESAVILSGRARSQRDVKRATITGLLIALSIYIIVTLITMGVLP HDKLVGSEKPFVDVLYAIVGNAGSVIMALLAILCLFGTMLGWILLGSEVPYQAAKAGD FPAFFAKTNKKGSPVIALIITNVMSQVFIFSVISRTISDAFTFLTTAATLAYLIPYLV SAIYSLKVVIKGETYDQLKGSRVRDGLIAILACAYSVFVIVTGTADLTTFILGIGLFF VGLIVYPFVSNKFQKEKQA*" /label="lysP CDS" gene complement(2937900..2939309) /gene="lysP" /locus_tag="BSU_33330" /old_locus_tag="BSU33330" /label="lysP gene" downshifts complement(2937915) /Source="Nicolas_upshifts" /id="D1724" /incds=0 /nref=168 /ntot=213 /MaxReadThrough="0.441040000000001" /MaxDrop="6.03347" /score="23.064706" /energy="-13.7" /TU="NA" /idTUdmin="U2613" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2938727..2938731 /Source="Nicolas_upshift_promotors" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2938749..2938765 /Source="Nicolas_upshift_promotors" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2938756 /Source="Nicolas_upshifts" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="upshifts" S_feature 2938763..2939730 /Source="Nicolas_S_feature" /locus_tag="new_3420519_3421486" /HighExp="S3, S4, S7, S5, S8, S6, Etha, M9-stat, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="7.6401427420847101E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.4" /TUlongSig="NA" /TUlongPSig="NA" /label="S1279" downshifts complement(2939411) /Source="Nicolas_upshifts" /id="D1725" /incds=0 /nref=1 /ntot=43 /MaxReadThrough="5.98281" /MaxDrop="3.61093" /score="-2.14086757" /energy="-5" /TU="U2613,U2614" /idTUdmin="U2614" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" misc_RNA complement(2939413..2939592) /gene="kswB" /locus_tag="BSU_misc_RNA_54" /product="lysine riboswitch" /experiment="publication(s) with functional evidences, PMID:22416067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22416067; Product type n: RNA" /label="kswB RNA" gene complement(2939413..2939592) /gene="kswB" /locus_tag="BSU_misc_RNA_54" /label="kswB gene" promotor_-10 complement(2939622..2939639) /Source="Nicolas_upshift_promotors" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2939633) /Source="Nicolas_upshifts" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2939654..2939661) /Source="Nicolas_upshift_promotors" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2939687 /Source="Nicolas_upshifts" /id="D1726" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.6441" /MaxDrop="3.53891" /score="-0.527038766" /energy="-4.8" /TU="U2612" /idTUdmin="U2612" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS complement(2939709..2939849) /gene="sspJ" /locus_tag="BSU_33340" /old_locus_tag="BSU33340" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054593.1" /db_xref="EnsemblGenomes-Gn:BSU33340" /db_xref="EnsemblGenomes-Tr:CAE01467" /db_xref="GOA:Q7WY58" /db_xref="InterPro:IPR014220" /db_xref="SubtiList:BG14174" /db_xref="UniProtKB/Swiss-Prot:Q7WY58" /translation="MGFFNKDKGKRSEKEKNVIQGALEDAGSALKDDPLQEAVQKKKN NR*" /label="sspJ CDS" gene complement(2939709..2939849) /gene="sspJ" /locus_tag="BSU_33340" /old_locus_tag="BSU33340" /label="sspJ gene" downshifts complement(2939719) /Source="Nicolas_upshifts" /id="D1727" /incds=0 /nref=40 /ntot=87 /MaxReadThrough="4.06523" /MaxDrop="5.5784" /score="-1.94521013" /energy="-14.5" /TU="U2614" /idTUdmin="U2614" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" upshifts complement(2939877) /Source="Nicolas_upshifts" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="upshifts" S_feature complement(2939879..2940467) /Source="Nicolas_S_feature" /locus_tag="new_3421635_3422223_c" /HighExp="S6, S8, S7, S5, BT, G135, Diami, G180, LBGstat, S4" /AntisenseName="yvsG" /AntisenseCor="0.46604658967097301" /AntisenseRegPval="-15.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1280" promotor_-10 complement(2939882..2939893) /Source="Nicolas_upshift_promotors" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="promotor_-10" promotor_-35 complement(2939907..2939913) /Source="Nicolas_upshift_promotors" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="promotor_-35" promotor_-35 2939939..2939946 /Source="Nicolas_upshift_promotors" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2939960 /Source="Nicolas_upshifts" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2939962..2939981 /Source="Nicolas_upshift_promotors" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2940016..2940498 /gene="yvsG" /locus_tag="BSU_33350" /old_locus_tag="BSU33350" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16267290, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_391215.1" /db_xref="EnsemblGenomes-Gn:BSU33350" /db_xref="EnsemblGenomes-Tr:CAB15340" /db_xref="GOA:O32205" /db_xref="InterPro:IPR007404" /db_xref="InterPro:IPR016956" /db_xref="SubtiList:BG14153" /db_xref="UniProtKB/Swiss-Prot:O32205" /translation="MTGKTHIMGGIASCTAAAYYYGFDPVLMAASGAVGALIPDICHT QSKIGRKFPILSKVVSSVFGHRTFTHSLLFMLIMFFITSTYIPDKNISAGLMIGMASH LILDAWTVNGIKLLFPSTIRVRLPLYMKTGSFSEQLVLAGLTLASCYYFYMLFHGRMF *" /label="yvsG CDS" gene 2940016..2940498 /gene="yvsG" /locus_tag="BSU_33350" /old_locus_tag="BSU33350" /label="yvsG gene" promotor_-35 2940512..2940519 /Source="Nicolas_upshift_promotors" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2940533..2940552 /Source="Nicolas_upshift_promotors" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2940545 /Source="Nicolas_upshifts" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2940598..2942451 /gene="ltaSP" /locus_tag="BSU_33360" /old_locus_tag="BSU33360" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15187182, 21255105, 23103977, 25288647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 21255105, 23103977, 25288647; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="primase of polyglycerolphosphate lipoteichoic acid (LTA) synthesis" /protein_id="NP_391216.1" /db_xref="EnsemblGenomes-Gn:BSU33360" /db_xref="EnsemblGenomes-Tr:CAB15341" /db_xref="GOA:O32206" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG14092" /db_xref="UniProtKB/Swiss-Prot:O32206" /translation="MKGTFFHNQRFLCFSILFMWIKTYVIYKLGFDLQIDTLLEELML LVNPLSFILPLFGIGLFLKENKQRAFLLIANLVLTVILISNTIFYGFYIDFITIPVLF QASNMSDMGSSVKELFHPLFIALFVDLVFLLLFARKTKHPQTKAAPHTIKRYYAASCG MLLCTLALAEVQQPKLLAHSFDREMLVKSIGLFQFHIYDTISQTVNISAKAFADEDSI TAIKNYTEADYSKPDQSKFGLAKGRNVIFVTLESTQSFVLNEKVNGKEITPFMNDLIK KSYSFDHFYQQTEQGKTSDSEFIVANSLYPSLSGAVFFTKSDHQFHTMYKSLKQHDYY SAVFHANHKTFWNRDVMYDTFGIDRFFDVDDFHVTPGTSTSWGLKDKEFLEQSAKKLK SLPQPFYSSFITLTNHFPFEIDEKDQLIDEFDSSSDLLNRYVTTVRYEDEALKHFIKK LKDEGLYENSMIVFMGDHYGISEAHNEAMAEFLGKDEITPYDNVQLQRVPFIIHIPGI TDQQPETIPDAGGQVDVRPTLMHLLGVETKGDIQFGNDLLSGDRTPFAVLRNGSFITN DYVYTKNTCYSQKTGEVLEDQDACLPYKEKANEELSLSDKILNGDLLRFSE*" /label="ltaSP CDS" gene 2940598..2942451 /gene="ltaSP" /locus_tag="BSU_33360" /old_locus_tag="BSU33360" /label="ltaSP gene" downshifts 2942437 /Source="Nicolas_upshifts" /id="D1728" /incds=0 /nref=30 /ntot=171 /MaxReadThrough="1.18268" /MaxDrop="3.6959" /score="21.1397957" /energy="-10.5" /TU="NA" /idTUdmin="U2615" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2942479..2943405) /gene="yvgK" /locus_tag="BSU_33370" /old_locus_tag="BSU33370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative molybdate binding regulator" /protein_id="NP_391217.1" /db_xref="EnsemblGenomes-Gn:BSU33370" /db_xref="EnsemblGenomes-Tr:CAB15342" /db_xref="GOA:O32207" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR010093" /db_xref="InterPro:IPR024370" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14093" /db_xref="UniProtKB/Swiss-Prot:O32207" /translation="MNETSSYTIEEVAGLLKVSKLTVYDLIKKGVLPAYRVGRQMRVD EEDLKQYKTNMRMSQPIAAKEAPKQVQEAEPDGRPNVMISGQDISMDILSKHLENAIQ ETPLRKYKGSLNSLIDMYQGKCDIVSLHLYDAETGQYNAPYVKRILTGEPFCLINVVL RKAGLYVQKGNPKNIQGWKDLKRADIRIINREKGSGARVLLDEQLGLLGVNPADVVGY GDIVTDHYAAASQVSSGQADAGIGAQHAAHMGSVDFIPLIDEQYDIVVLKKNEQLLKA VKEILNSEDYKANLSHLNGYETKLTGKVILET*" /label="yvgK CDS" gene complement(2942479..2943405) /gene="yvgK" /locus_tag="BSU_33370" /old_locus_tag="BSU33370" /label="yvgK gene" downshifts complement(2942491) /Source="Nicolas_upshifts" /id="D1729" /incds=0 /nref=232 /ntot=260 /MaxReadThrough="0.15268" /MaxDrop="6.72558" /score="21.9965704" /energy="-10.5" /TU="NA" /idTUdmin="U2617" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2943417..2943436) /Source="Nicolas_upshift_promotors" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2943438) /Source="Nicolas_upshifts" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2943452..2943455) /Source="Nicolas_upshift_promotors" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2943474..2943493 /Source="Nicolas_upshift_promotors" /id="U2618" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.95104895104895" /xcortree=2395 /SigmaFactorBS="tttattataccttttcgccgaatgtaaaaaaacccacataaa ccaaacataATCAGTTATAATTAGTTATAtctaatgataaggggtgcaatcatgttta a" /listShort="yvgL, yvgM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2943483 /Source="Nicolas_upshifts" /id="U2618" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.95104895104895" /xcortree=2395 /SigmaFactorBS="tttattataccttttcgccgaatgtaaaaaaacccacataaa ccaaacataATCAGTTATAATTAGTTATAtctaatgataaggggtgcaatcatgttta a" /listShort="yvgL, yvgM" /GFF_Attribute="listLong" /label="upshifts" CDS 2943516..2944298 /gene="modA" /locus_tag="BSU_33380" /old_locus_tag="BSU33380" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9302996; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="molybdate-binding lipoprotein" /protein_id="NP_391218.1" /db_xref="EnsemblGenomes-Gn:BSU33380" /db_xref="EnsemblGenomes-Tr:CAB15343" /db_xref="GOA:O32208" /db_xref="InterPro:IPR005950" /db_xref="SubtiList:BG14094" /db_xref="UniProtKB/Swiss-Prot:O32208" /translation="MFKKYSIFIAALTAFLLVAGCSSNQSSTDSEKKVTLTISAAASA QDALEEIQKNYEKDHQHITIQDNYGSSGALQKQISQGAGADLFFSAAEDKFKKLVDDG DIAKKDSTELVGNEIVLVVPKNGDSPVTSFSNLAESEKIALGTPESVPAGAYGKESLT KLSLWDKVKDKIVYGKDVRQVLSYVETGNVDAGVVYKTDALVSKKVNIVDEAKADTHS PIVYPLGIVKDTKHRKEAKEFYEYLQSDEAMKVFEKYGFTAE*" /label="modA CDS" gene 2943516..2944298 /gene="modA" /locus_tag="BSU_33380" /old_locus_tag="BSU33380" /label="modA gene" CDS 2944270..2944962 /gene="modB" /locus_tag="BSU_33390" /old_locus_tag="BSU33390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="molybdenum transport permease" /protein_id="NP_391219.3" /db_xref="EnsemblGenomes-Gn:BSU33390" /db_xref="EnsemblGenomes-Tr:CAB15344" /db_xref="GOA:O32209" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR011867" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14095" /db_xref="UniProtKB/Swiss-Prot:O32209" /translation="MRNMALLPSSISASEFFTPVVLSFQVAAVAGIVVIILGTLAGAW MSRASFFGKTALETCFMLPLVLPPTVVGFILIVIFGKHSFIGQAIEWIFQQPVIFTWW AAVIASAVVAFPLMYQSAKTGFADIDPDIQGAAMVDGASRWKVFIHISVPLAYPSLLT GSILSLARALGEFGATLMFAGNIPGVTQTLPTAIYVALDSGNNTLAWAWVVCIVVISF LMLFFIQQKKTH*" /label="modB CDS" gene 2944270..2944962 /gene="modB" /locus_tag="BSU_33390" /old_locus_tag="BSU33390" /label="modB gene" downshifts 2944954 /Source="Nicolas_upshifts" /id="D1730" /incds=0 /nref=40 /ntot=195 /MaxReadThrough="0.43895" /MaxDrop="4.92503" /score="19.0609965" /energy="-9.4" /TU="NA" /idTUdmin="U2618" /TUdmin=9 /isTUend="TRUE" /label="downshifts" CDS complement(2944993..2945823) /gene="pgoN" /locus_tag="BSU_33400" /old_locus_tag="BSU33400" /EC_number="1.1.1.283" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11544192, 16232966, 17114254, 19585557" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544192, 16232966, 17114254, 19585557; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous glyoxal/methylglyoxal reductase" /protein_id="NP_391220.1" /db_xref="EnsemblGenomes-Gn:BSU33400" /db_xref="EnsemblGenomes-Tr:CAB15345" /db_xref="GOA:O32210" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:3D3F" /db_xref="PDB:3F7J" /db_xref="SubtiList:BG14096" /db_xref="UniProtKB/Swiss-Prot:O32210" /translation="MPTSLKDTVKLHNGVEMPWFGLGVFKVENGNEATESVKAAIKNG YRSIDTAAIYKNEEGVGIGIKESGVAREELFITSKVWNEDQGYETTLAAFEKSLERLQ LDYLDLYLIHWPGKDKYKDTWRALEKLYKDGKIRAIGVSNFQVHHLEELLKDAEIKPM VNQVEFHPRLTQKELRDYCKGQGIQLEAWSPLMQGQLLDNEVLTQIAEKHNKSVAQVI LRWDLQHGVVTIPKSIKEHRIIENADIFDFELSQEDMDKIDALNKDERVGPNPDELLF *" /label="pgoN CDS" gene complement(2944993..2945823) /gene="pgoN" /locus_tag="BSU_33400" /old_locus_tag="BSU33400" /label="pgoN gene" downshifts complement(2944999) /Source="Nicolas_upshifts" /id="D1731" /incds=0 /nref=190 /ntot=269 /MaxReadThrough="4.7445" /MaxDrop="7.9269" /score="27.8070829" /energy="-9.7" /TU="U2620" /idTUdmin="U2620" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-35 2945686..2945690 /Source="Nicolas_upshift_promotors" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2945706..2945710 /Source="Nicolas_upshift_promotors" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2945715 /Source="Nicolas_upshifts" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2945825 /Source="Nicolas_upshifts" /id="D1732" /incds=0 /nref=2 /ntot=122 /MaxReadThrough="0.95687" /MaxDrop="4.12116" /score="31.5807071" /energy="-11.6" /TU="NA" /idTUdmin="U2618" /TUdmin=880 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2945853..2945872) /Source="Nicolas_upshift_promotors" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2945871) /Source="Nicolas_upshifts" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2945887..2945894) /Source="Nicolas_upshift_promotors" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2945979..2945985 /Source="Nicolas_upshift_promotors" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2945999 /Source="Nicolas_upshifts" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2946000..2946018 /Source="Nicolas_upshift_promotors" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2946046..2946531 /gene="yvgO" /locus_tag="BSU_33410" /old_locus_tag="BSU33410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11988534, 22307285, 25217289; Product type f: factor" /codon_start=1 /transl_table=11 /product="exported stress induced factor" /protein_id="NP_391221.1" /db_xref="EnsemblGenomes-Gn:BSU33410" /db_xref="EnsemblGenomes-Tr:CAB15346" /db_xref="SubtiList:BG14097" /db_xref="UniProtKB/Swiss-Prot:O32211" /translation="MKRIRIPMTLALGAALTIAPLSFASAEENPAPKMSQTTTAGTTA ADVGLNVNLDVLGIANQIADAIKSAQNRDGFVKNLMESSFYASGQKYNVMVFNLSQEY EDHLNGVQFYGSAVYDGITYGIWVFEDGTFTNKGDGGWINWAFRGWFDRDGSTVAFHR P*" /label="yvgO CDS" gene 2946046..2946531 /gene="yvgO" /locus_tag="BSU_33410" /old_locus_tag="BSU33410" /label="yvgO gene" downshifts 2946530 /Source="Nicolas_upshifts" /id="D1733" /incds=0 /nref=18 /ntot=93 /MaxReadThrough="3.44281" /MaxDrop="6.83046" /score="31.5807071" /energy="-11.6" /TU="U2621" /idTUdmin="U2621" /TUdmin="-571" /isTUend="FALSE" /label="downshifts" CDS complement(2946575..2948587) /gene="nhaK" /locus_tag="BSU_33420" /old_locus_tag="BSU33420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16021482, 16850406, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16021482, 16850406, 28420751; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter" /protein_id="NP_391222.1" /db_xref="EnsemblGenomes-Gn:BSU33420" /db_xref="EnsemblGenomes-Tr:CAB15347" /db_xref="GOA:O32212" /db_xref="InterPro:IPR004705" /db_xref="InterPro:IPR006153" /db_xref="InterPro:IPR018422" /db_xref="SubtiList:BG14098" /db_xref="UniProtKB/Swiss-Prot:O32212" /translation="MDIFLVVLVLLTIIAISNIVNRFIPFIPVPLIQVALGILAASFP QGLHFELNTELFFVLFIAPLLFNDGKRTPRAELWNLRAPILLLALGLVFATVIVGGYT IHWMIPAIPLAAAFGLAAILSPTDVVAVSALSGRVKMPKGILRLLEGEGLMNDASGLV AFKFAIAAAVTGAFSLAQAAVSFVFISLGGLLCGVVISFLIIRFRLFLRRLGMQDVTM HMLIQILTPFVIYLAAEEIGVSGILAVVAGGITHAVEQDRLESTMIKLQIVSSSTWNI ILFILNGLVFVILGTQIPDVISVIFNDTAISNMKVIGYILVITFTLMLLRFLWVLFFW NGKWFFNKDQNIYKPGLRSTLLISISGVRGAVTLAGSFSIPYFLEDGTPFPERNLILF LAAGVILCTLVIATVVLPILTEKEEEDEERNKKLLTARRKLIKTALQTIKEDMNETNK TASLAVIAEYNEKMKNLRFQQYTSSNRIKKHERKVRAQGVKAEQEALMKMLERGDIPE ETANVLQERFNELEILYANPFKVGLSKTRLKRLMYWIFFGEHKKPEMSILNEAGLIRA TRVKTAKAAIEYLEKHKTDEHKEVFLSVITFYKQLIFRLEHSHHELKSSAHFENQKLE VKLKAVQAIRNEIQTLFEEREISRDISHELRQYINDVEAAMLEGGE*" /label="nhaK CDS" gene complement(2946575..2948587) /gene="nhaK" /locus_tag="BSU_33420" /old_locus_tag="BSU33420" /label="nhaK gene" downshifts complement(2946583) /Source="Nicolas_upshifts" /id="D1734" /incds=0 /nref=118 /ntot=238 /MaxReadThrough="2.66359" /MaxDrop="5.82216" /score="41.6492295" /energy="-13.2" /TU="NA" /idTUdmin="U2622" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(2948253..2948257) /Source="Nicolas_upshift_promotors" /id="U2622" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.403596403596404" /psig="0.04995004995005" /xcortree=1527 /SigmaFactorBS="tgtatttgcgactgtgattgtaggcggctacacgattcactg gatgattcctgctattCCGCTggcagcggcctttggacttgcggccattctttcaccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2948255) /Source="Nicolas_upshifts" /id="U2622" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.403596403596404" /psig="0.04995004995005" /xcortree=1527 /SigmaFactorBS="tgtatttgcgactgtgattgtaggcggctacacgattcactg gatgattcctgctattCCGCTggcagcggcctttggacttgcggccattctttcaccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2948588..2948739) /Source="Nicolas_S_feature" /locus_tag="new_3430344_3430495_c" /HighExp="dia5, T0.30H, T-0.40H, Salt, Diami, T1.0H, T0.0H, T1.30H, dia15, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.746, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1281" misc_feature complement(2948716..2948734) /Source="Nicolas_upshift_promotors" /id="U2623" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.341658341658342" /psig="0.746253746253746" /xcortree=1528 /SigmaFactorBS="ttctataatttgctcttctgcaaaaaagttcactgtgagcat atcatgagaaaaaataccctaaaAAGGGTACTATAAAAGAAGacaagtgtggagagaa c" /listShort="S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2948739) /Source="Nicolas_upshifts" /id="U2623" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.341658341658342" /psig="0.746253746253746" /xcortree=1528 /SigmaFactorBS="ttctataatttgctcttctgcaaaaaagttcactgtgagcat atcatgagaaaaaataccctaaaAAGGGTACTATAAAAGAAGacaagtgtggagagaa c" /listShort="S1281, nhaK" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2948842..2950557) /gene="cysI" /locus_tag="BSU_33430" /old_locus_tag="BSU33430" /EC_number="1.8.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445163, 12169591, 16267287" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445163, 12169591, 16267287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory sulfite reductase (hemoprotein beta-subunit)" /protein_id="NP_391223.1" /db_xref="EnsemblGenomes-Gn:BSU33430" /db_xref="EnsemblGenomes-Tr:CAB15348" /db_xref="GOA:O32213" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR006066" /db_xref="InterPro:IPR006067" /db_xref="InterPro:IPR011786" /db_xref="InterPro:IPR036136" /db_xref="SubtiList:BG14099" /db_xref="UniProtKB/Swiss-Prot:O32213" /translation="MVTKILKAPDGSPSDVERIKKESDYLRGTLKEVMLDRISAGIPD DDNRLMKHHGSYLQDDRDLRNERQKQKLEPAYQFMLRVRMPGGVSTPEQWLVMDDLSQ KYGNGTLKLTTRETFQMHGILKWNMKKTIQTIHSALLDTIAACGDVNRNVMCASNPYQ SEIHSEVYEWSKKLSDDLLPRTRAYHEIWLDEERVAGTPEEEVEPMYGPLYLPRKFKI GIAVPPSNDIDVFSQDLGFIAIVEDGKLIGFNVAIGGGMGMTHGDTATYPQLAKVIGF CRPEQMYDVAEKTITIQRDYGNRSVRKNARFKYTVDRLGLENVKEELENRLGWSLEEA KPYHFDHNGDRYGWVEGIEDKWHFTLFVEGGRITDYDDYKLMTGLREIAKVHTGEFRL TANQNLMIANVSSDKKEEISALIEQYGLTDGKHYSALRRSSMACVALPTCGLAMAEAE RYLPTLLDKIEEIIDENGLRDQEITIRMTGCPNGCARHALGEIGFIGKAPGKYNMYLG AAFDGSRLSKMYRENIGEADILSELRILLSRYAKEREEGEHFGDFVIRAGIIKATTDG TNFHD*" /label="cysI CDS" gene complement(2948842..2950557) /gene="cysI" /locus_tag="BSU_33430" /old_locus_tag="BSU33430" /label="cysI gene" downshifts complement(2948849) /Source="Nicolas_upshifts" /id="D1735" /incds=0 /nref=211 /ntot=254 /MaxReadThrough="3.28258" /MaxDrop="6.31358" /score="23.5256972" /energy="-13.8" /TU="U2624" /idTUdmin="U2624" /TUdmin="-572" /isTUend="FALSE" /label="downshifts" CDS complement(2950583..2952400) /gene="cysJ" /locus_tag="BSU_33440" /old_locus_tag="BSU33440" /EC_number="1.8.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445163, 12169591, 16267287, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445163, 12169591, 16267287, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory sulfite reductase (flavoprotein alpha-subunit)" /protein_id="NP_391224.1" /db_xref="EnsemblGenomes-Gn:BSU33440" /db_xref="EnsemblGenomes-Tr:CAB15349" /db_xref="GOA:O32214" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010199" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG14100" /db_xref="UniProtKB/Swiss-Prot:O32214" /translation="MQLQVMNSPFNQEQAELLNRLLPTLTESQKIWLSGYLSAQSVSA QEAAGTPAAAVSAEAPAPAVSKEVTVLYGSQTGNAQGLAENAGKQLEQSGFQVTVSSM SDFKPNQLKKVTNLLIVVSTHGEGEPPDNALSFHEFLHGRRAPKLEDLRFSVLALGDS SYEFFCQTGKEFDQRLEELGGKRISPRVDCDLDYDEPAAEWLEGVLKGLNEAGGGSAA PAPAAASQTGESSYSRTNPFRAEVLENLNLNGRGSNKETRHVELSLEGSGLTYEPGDS LGVYPENDPELVELLLKEMNWDPEEIVTLNKQGDVRPLKEALISHYEITVLTKPLLEQ AAQLTGNDELRELLAPGNEENVKAYIEGRDLLDLVRDYGPFSVSAQEFVSILRKMPAR LYSIASSLSANPDEVHLTIGAVRYDAHGRERKGVCSILCAERLQPGDTLPVYVQHNQN FKLPKDPETPIIMVGPGTGVAPFRSFMQEREETGAEGKAWMFFGDQHFVTDFLYQTEW QNWLKDGVLTKMDVAFSRDTEEKVYVQHRMLEHSAELFEWLQEGAAVYICGDEKHMAH DVHNTLLEIIEKEGNMSREEAEAYLADMQQQKRYQRDVY*" /label="cysJ CDS" gene complement(2950583..2952400) /gene="cysJ" /locus_tag="BSU_33440" /old_locus_tag="BSU33440" /label="cysJ gene" promotor_-10 complement(2952442..2952461) /Source="Nicolas_upshift_promotors" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2952451..2952458 /Source="Nicolas_upshift_promotors" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2952461) /Source="Nicolas_upshifts" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="upshifts" upshifts 2952464 /Source="Nicolas_upshifts" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2952471..2952490 /Source="Nicolas_upshift_promotors" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2952474..2952481) /Source="Nicolas_upshift_promotors" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2952571..2954895) /gene="helD" /locus_tag="BSU_33450" /old_locus_tag="BSU33450" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11544244, 24520113" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544244, 24520113; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription factor" /protein_id="NP_391225.1" /db_xref="EnsemblGenomes-Gn:BSU33450" /db_xref="EnsemblGenomes-Tr:CAB15350" /db_xref="GOA:O32215" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027785" /db_xref="SubtiList:BG14101" /db_xref="UniProtKB/Swiss-Prot:O32215" /translation="MNQQDKEWKEEQSRIDEVLKELEKKERFLETSAGGLKHDIIGLR KSFWEDVKVNFDDAHEAIETMASIKQQAELLSDREHNHRRMDQQLKRIHQLKKSPYFG RIDFIENGEEQAERIYIGLASCLDEKEEHFLIYDWRAPISSLYYNYSPGKAEYEVPGE TIEGEMVLKRQFMIKNGTLKAMFNTDMTIGDEMLQEVLSHHSDTQMKNIVSTIQKEQN QIIRNEKSKILIVQGAAGSGKTSAALQRVAYLLYRHRGVIDAGQIVLFSPNFLFNSYV SSVLPELGEENMEQATFQEYIEHRLGRKFKCESPFDQLEYCLTETKGGDFPTRLAGIT WKAGLSFQQFINEYVTRLSSEGMIFKNIIFRGQKLITKEQIQSYFYSLDQNHSIPNRM EQTAKWLLSELNKLEKKERRKDWVVHEAELLDKEDYLDVYKKLQERKRFSESTFNDYQ REQQLLAAIIVKKAFKPLKQAVRLLAFLDVTQLYLQLFSGWGGKFQHEKMDAIGELTR SAFTDNKLLYEDAAPFLYMQDLIEGRKKNTKIKHLFIDEAQDYSPFQMAYMRSIFPAA SMTVLGDINQSIYAHTINGDQRMDACFEDEPAEYVRLKRTYRSTRQIVEFTKAMLQDG ADIEPFNRSGEMPLVVKTEGHESLCQKLAQEIGRLKKKGHETIAVICKTAHQCIQAHA HMSEYTDVRLIHKENQPFQKGVCVIPVYLAKGIEFDAVLVYDASEEHYHTEHDRRLLY TACTRAMHMLAVFYTGEASPFVTAVPPHLYQIAE*" /label="helD CDS" gene complement(2952571..2954895) /gene="helD" /locus_tag="BSU_33450" /old_locus_tag="BSU33450" /label="helD gene" downshifts complement(2952589) /Source="Nicolas_upshifts" /id="D1736" /incds=0 /nref=26 /ntot=168 /MaxReadThrough="1.20405" /MaxDrop="4.59044" /score="18.6044234" /energy="-8.5" /TU="NA" /idTUdmin="U2628" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2954915..2954922 /Source="Nicolas_upshift_promotors" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2954937..2954956 /Source="Nicolas_upshift_promotors" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(2954938..2954953) /Source="Nicolas_upshift_promotors" /id="U2627" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.398601398601399" /xcortree=685 /SigmaFactorBS="attataaattgtatttgccagtttgcatcatatatttaatat atgtatccAATTATATTTTACAGTatttcatctatgtttgtcaactattttctggagg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2954941 /Source="Nicolas_upshifts" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2954943) /Source="Nicolas_upshifts" /id="U2627" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.398601398601399" /xcortree=685 /SigmaFactorBS="attataaattgtatttgccagtttgcatcatatatttaatat atgtatccAATTATATTTTACAGTatttcatctatgtttgtcaactattttctggagg t" /listShort="helD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2954988..2955007) /Source="Nicolas_upshift_promotors" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2954997) /Source="Nicolas_upshifts" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2955023..2955029) /Source="Nicolas_upshift_promotors" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2955033..2955052) /Source="Nicolas_upshift_promotors" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2955053) /Source="Nicolas_upshifts" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2955066..2955074) /Source="Nicolas_upshift_promotors" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2955080) /Source="Nicolas_upshifts" /id="D1737" /incds=0 /nref=19 /ntot=158 /MaxReadThrough="2.30604" /MaxDrop="4.26839" /score="16.6103553" /energy="-9.2" /TU="NA" /idTUdmin="U2630" /TUdmin=17 /isTUend="TRUE" /label="downshifts" CDS complement(2955093..2955701) /gene="yvgT" /locus_tag="BSU_33460" /old_locus_tag="BSU33460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391226.1" /db_xref="EnsemblGenomes-Gn:BSU33460" /db_xref="EnsemblGenomes-Tr:CAB15351" /db_xref="GOA:O32216" /db_xref="InterPro:IPR005115" /db_xref="SubtiList:BG14102" /db_xref="UniProtKB/Swiss-Prot:O32216" /translation="MAWELLSVIGIIAFAVSGAIVAMEEEYDILGVYILGIVTAFGGG AIRNLLIGVPVSALWEQGAYFQIALLSITIVFLFPKLLLKHWNKWGNLSDAIGLAAFA IQGALYAVKMGHPLSAVIVAAVLTGSGGGIIRDLLAGRKPLVLKAEIYAVWAALGGLI VGLGWLGNSFGLYVLFFVLVVCRVCSYMFNWKLPNRSFRLDN*" /label="yvgT CDS" gene complement(2955093..2955701) /gene="yvgT" /locus_tag="BSU_33460" /old_locus_tag="BSU33460" /label="yvgT gene" promotor_-10 complement(2955740..2955759) /Source="Nicolas_upshift_promotors" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2955757) /Source="Nicolas_upshifts" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2955775..2955779) /Source="Nicolas_upshift_promotors" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2955888..2956304) /gene="bdbC" /locus_tag="BSU_33470" /old_locus_tag="BSU33470" /function="16.6: Maintain" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10455116, 11872755, 15661011, 15849754, 16751195, 16850406, 17088376" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10455116, 11872755, 15661011, 15849754, 16751195, 16850406, 17088376; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_391227.1" /db_xref="EnsemblGenomes-Gn:BSU33470" /db_xref="EnsemblGenomes-Tr:CAB15352" /db_xref="GOA:O32217" /db_xref="InterPro:IPR003752" /db_xref="InterPro:IPR012187" /db_xref="InterPro:IPR023380" /db_xref="SubtiList:BG14103" /db_xref="UniProtKB/Swiss-Prot:O32217" /translation="MKNRIVFLYASWVVALIAMLGSLYFSEIRKFIPCELCWYQRILM YPLVLILGIATFQGDTRVKKYVLPMAIIGAFISIMHYLEQKVPGFSGIKPCVSGVPCS GQYINWFGFITIPFLALIAFILIIIFMCLLKGEKSE*" /label="bdbC CDS" gene complement(2955888..2956304) /gene="bdbC" /locus_tag="BSU_33470" /old_locus_tag="BSU33470" /label="bdbC gene" downshifts complement(2955898) /Source="Nicolas_upshifts" /id="D1738" /incds=0 /nref=120 /ntot=264 /MaxReadThrough="1.31968" /MaxDrop="6.21723" /score="26.5991603" /energy="-12.7" /TU="NA" /idTUdmin="U2631" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(2956309..2956977) /gene="bdbD" /locus_tag="BSU_33480" /old_locus_tag="BSU33480" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11744713, 11872755, 12637552, 15661011, 17501922, 19535335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11744713, 11872755, 12637552, 15661011, 17501922, 19535335; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_391228.1" /db_xref="EnsemblGenomes-Gn:BSU33480" /db_xref="EnsemblGenomes-Tr:CAB15353" /db_xref="GOA:O32218" /db_xref="InterPro:IPR012336" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:3EU3" /db_xref="PDB:3EU4" /db_xref="PDB:3GH9" /db_xref="PDB:3GHA" /db_xref="SubtiList:BG14104" /db_xref="UniProtKB/Swiss-Prot:O32218" /translation="MKKKQQSSAKFAVILTVVVVVLLAAIVIINNKTEQGNDAVSGQP SIKGQPVLGKDDAPVTVVEFGDYKCPSCKVFNSDIFPKIQKDFIDKGDVKFSFVNVMF HGKGSRLAALASEEVWKEDPDSFWDFHEKLFEKQPDTEQEWVTPGLLGDLAKSTTKIK PETLKENLDKETFASQVEKDSDLNQKMNIQATPTIYVNDKVIKNFADYDEIKETIEKE LKGK*" /label="bdbD CDS" gene complement(2956309..2956977) /gene="bdbD" /locus_tag="BSU_33480" /old_locus_tag="BSU33480" /label="bdbD gene" promotor_-10 complement(2957029..2957048) /Source="Nicolas_upshift_promotors" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2957044) /Source="Nicolas_upshifts" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2957055) /Source="Nicolas_upshifts" /id="D1739" /incds=0 /nref=3 /ntot=9 /MaxReadThrough="7.34296" /MaxDrop="3.6233" /score="12.4442247" /energy="-11.3" /TU="U2632" /idTUdmin="U2633" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(2957062..2957067) /Source="Nicolas_upshift_promotors" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2957097..2959205) /gene="cadA" /locus_tag="BSU_33490" /old_locus_tag="BSU33490" /EC_number="3.6.3.3" /EC_number="3.6.3.5" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7721839, 8037745, 11934502, 11922674, 12644235, 12779235, 14663075, 16901659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7721839, 8037745, 11934502, 11922674, 12644235, 12779235, 14663075, 16901659; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Cd(II), Zn(II) and Co(II) exporter (ATPase)" /protein_id="NP_391229.3" /db_xref="EnsemblGenomes-Gn:BSU33490" /db_xref="EnsemblGenomes-Tr:CAB15354" /db_xref="GOA:O32219" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036163" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG14105" /db_xref="UniProtKB/Swiss-Prot:O32219" /translation="MRLVKQEYVLDGLDCSNCARKIENGVKGIKGINGCAVNFAASTL TVSADGKEEQWVTNKVEKKVKSIDPHVTVRQKHIKKSADDGYRNRMVNMLIRMAAAVI LGAAAYLVQSGTIEFFLFLGAYLIIGGDIIIRAVKNIIRGQVFDEHFLMALATIGAFL IQQYPEGVAVMLFYQIGELFQGAAVSRSRKSISALMDIRPDYANLKTKNGIEQVSSED VQTGDIIVVNPGESIPLDGKVVQGSAMVDTSALTGESVPRKAAEGQDVMSGFINQNGV LHIEVTKGYQESAVSKILDLVQNASSRKARTENFITKFAKYYTPAVVIIAVLLAFVPP LVLSGAALSDWVYRALIFLVISCPCALVVSIPLGFFGGIGAASKAGVLVKGSNYLEAL NQVKYAVFDKTGTLTKGSFEVTEIKPAEGFTKDRLLEAAAYAELHSQHPIAESVRKAY GKMLSSDEIESYEEISGHGIFAKVNGTEILAGNKKLMEREQIEDVPDENAGTIVHVAV DQRYAGAIIIADEIKEDAAQAVADLKSLGIKQTAMLTGDSKQTGEAVGKQLGIGEVYA ELLPQDKVAQVEALEAKLLPSEKLIFVGDGINDTPVLARADIGVAMGGLGSDAAVEAA DIVLMTDQPSKIAEAIRIAKRTRRIVWQNIGFALGVKAIFLILGAFGIATMWEAVFSD VGVTLLAVANAMRVMRLKNK*" /label="cadA CDS" gene complement(2957097..2959205) /gene="cadA" /locus_tag="BSU_33490" /old_locus_tag="BSU33490" /label="cadA gene" S_feature complement(2959197..2959298) /Source="Nicolas_S_feature" /locus_tag="new_3440953_3441054_c" /HighExp="dia5, LBGtran, LBGstat, Diami, LBGexp, Gly, Lbtran, T0.30H, M40t45, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.982, 0.999" /TUlongSig="SigB" /TUlongPSig="0.587" /label="S1282" promotor_-10 complement(2959292..2959311) /Source="Nicolas_upshift_promotors" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2959298) /Source="Nicolas_upshifts" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2959327..2959334) /Source="Nicolas_upshift_promotors" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2959365..2961773) /gene="copA" /locus_tag="BSU_33500" /old_locus_tag="BSU33500" /EC_number="3.6.3.54" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11922674, 11934502, 12644235, 14663075, 18215122, 19378562, 19751213, 20233928, 22077885, 22531974" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11922674, 11934502, 12644235, 14663075, 18215122, 19378562, 19751213, 20233928, 22077885, 22531974; Product type t : transporter" /codon_start=1 /transl_table=11 /product="copper transporter ATPase" /protein_id="NP_391230.2" /db_xref="EnsemblGenomes-Gn:BSU33500" /db_xref="EnsemblGenomes-Tr:CAB15355" /db_xref="GOA:O32220" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR006122" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036163" /db_xref="InterPro:IPR036412" /db_xref="PDB:1JWW" /db_xref="PDB:1KQK" /db_xref="PDB:1OPZ" /db_xref="PDB:1OQ3" /db_xref="PDB:1OQ6" /db_xref="PDB:1P6T" /db_xref="PDB:2RML" /db_xref="PDB:2VOY" /db_xref="SubtiList:BG14106" /db_xref="UniProtKB/Swiss-Prot:O32220" /translation="MSEQKEIAMQVSGMTCAACAARIEKGLKRMPGVTDANVNLATET SNVIYDPAETGTAAIQEKIEKLGYHVVTEKAEFDIEGMTCAACANRIEKRLNKIEGVA NAPVNFALETVTVEYNPKEASVSDLKEAVDKLGYKLKLKGEQDSEAAAKKKEERKQTA RLIFSAVLSFPLLWAMVSHFTFTSFIWVPDIFLNPWMQFALATPVQFLIGWPFYVGAY KALRNKSANMDVLVALGTTAAYAYSLYLTFQSIGSHGHTDGLYYETSAILLTLILLGK LFETKAKGRSSDAIKKLMKLQAKTATVVRDGQEQIIPIDEVLVNDIVYVKPGERIPVD GEVVEGRSAVDESMITGESLPVDKNPGDSVTGSTVNANGFLKIKAVNVGKDTALSHII KIVEEAQGSKAPIQRLADQISGIFVPIVLGIAVLTFLIWYLWAAPGDFAEAISKFIAV LVIACPCALGLATPTSIMAGSGRAAEFGILFKGGEHLEKTHRLDTIVLDKTGTVTNGK PRLTDAIPFGRFEEKDLLQFAAAAETGSEHPLGEAIIAGVKDKGLEIPKLTRFEAKVG AGILAEAGGKSILVGTRKLMESEQVEHGALLAQMEELEAEGKTVMLVSIDGEAAGLVA VADTIKDTSRKAVARLKELGLDVIMMTGDNRRTAEAIAKEAGIANIIAEVLPEQKAAE IARLQKEGRQTAMVGDGINDAPALATADIGMAIGTGTDIAMETADITLIRGDLNSIAD AIRMSRLTMKNIKQNLFWALGYNSLGIPIAALGFLAPWIAGAAMAFSSVSVVLNALRL QKVK*" /label="copA CDS" gene complement(2959365..2961773) /gene="copA" /locus_tag="BSU_33500" /old_locus_tag="BSU33500" /label="copA gene" downshifts complement(2959387) /Source="Nicolas_upshifts" /id="D1740" /incds=0 /nref=15 /ntot=68 /MaxReadThrough="5.02116" /MaxDrop="3.63756" /score="26.9828242" /energy="-7.9" /TU="U2633" /idTUdmin="U2635" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2959453) /Source="Nicolas_upshifts" /id="D1741" /incds=1 /nref=52 /ntot=227 /MaxReadThrough="5.93949" /MaxDrop="4.28993" /score="26.9828242" /energy="-7.9" /TU="U2633,U2635" /idTUdmin="U2635" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(2961774..2961856) /Source="Nicolas_S_feature" /locus_tag="new_3443530_3443612_c" /HighExp="Diami, dia5, dia15, Gly, T0.30H, Heat, T1.0H, T1.30H, T0.0H, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.999, 0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S1283" CDS complement(2961857..2962066) /gene="copZ" /locus_tag="BSU_33510" /old_locus_tag="BSU33510" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11934502, 12238948, 12590580, 14621987, 14663075, 15212800, 18419582, 27197762, 28078344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11934502, 12238948, 12590580, 14621987, 14663075, 15212800, 18419582, 27197762, 28078344; Product type f: factor" /codon_start=1 /transl_table=11 /product="copper insertion chaperone and transporter component" /protein_id="NP_391231.1" /db_xref="EnsemblGenomes-Gn:BSU33510" /db_xref="EnsemblGenomes-Tr:CAB15356" /db_xref="GOA:O32221" /db_xref="InterPro:IPR000428" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR006122" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR036163" /db_xref="PDB:1K0V" /db_xref="PDB:1P8G" /db_xref="PDB:2QIF" /db_xref="PDB:3I9Z" /db_xref="SubtiList:BG14107" /db_xref="UniProtKB/Swiss-Prot:O32221" /translation="MEQKTLQVEGMSCQHCVKAVETSVGELDGVSAVHVNLEAGKVDV SFDADKVSVKDIADAIEDQGYDVAK*" /label="copZ CDS" gene complement(2961857..2962066) /gene="copZ" /locus_tag="BSU_33510" /old_locus_tag="BSU33510" /label="copZ gene" promotor_-10 complement(2962090..2962109) /Source="Nicolas_upshift_promotors" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="promotor_-10" upshifts complement(2962111) /Source="Nicolas_upshifts" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="upshifts" promotor_-35 complement(2962122..2962128) /Source="Nicolas_upshift_promotors" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="promotor_-35" CDS complement(2962140..2962445) /gene="csoR" /locus_tag="BSU_33520" /old_locus_tag="BSU33520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17143269, 18048925, 22904286, 24831014, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17143269, 18048925, 22904286, 24831014, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="repressor of copper utilisation proteins-Cu(I)" /protein_id="NP_391232.1" /db_xref="EnsemblGenomes-Gn:BSU33520" /db_xref="EnsemblGenomes-Tr:CAB15357" /db_xref="GOA:O32222" /db_xref="InterPro:IPR003735" /db_xref="SubtiList:BG14108" /db_xref="UniProtKB/Swiss-Prot:O32222" /translation="MEKHNEHKTLNHKSSKEKDQITNRLKRIEGQVRGIQNMVENDRY CVDILVQISAVQAAMKNVALHLLEDHAHHCVADAIKSGDGEQAISELLDVFKKFTKS* " /label="csoR CDS" gene complement(2962140..2962445) /gene="csoR" /locus_tag="BSU_33520" /old_locus_tag="BSU33520" /label="csoR gene" misc_feature 2962409..2962428 /Source="Nicolas_upshift_promotors" /id="U2634" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig="0.986013986013986" /xcortree=2475 /SigmaFactorBS="tcaatccgcttaagccggtttgtaatctgatccttttctttc gagctttTATGGTTTAATGTTTTATGTtcgttatgcttttccatgcgtacacctctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2962420 /Source="Nicolas_upshifts" /id="U2634" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig="0.986013986013986" /xcortree=2475 /SigmaFactorBS="tcaatccgcttaagccggtttgtaatctgatccttttctttc gagctttTATGGTTTAATGTTTTATGTtcgttatgcttttccatgcgtacacctctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2962459..2962478) /Source="Nicolas_upshift_promotors" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="promotor_-10" upshifts complement(2962485) /Source="Nicolas_upshifts" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="upshifts" promotor_-35 complement(2962492..2962498) /Source="Nicolas_upshift_promotors" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="promotor_-35" promotor_-35 2962537..2962543 /Source="Nicolas_upshift_promotors" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2962558..2962576 /Source="Nicolas_upshift_promotors" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2962566 /Source="Nicolas_upshifts" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="upshifts" CDS 2962573..2963649 /gene="iolW" /locus_tag="BSU_33530" /old_locus_tag="BSU33530" /EC_number="1.1.1.371" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15937154, 20133360, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15937154, 20133360, 28693424; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol 2-dehydrogenase (NADP(+)-dependent)" /protein_id="NP_391233.1" /db_xref="EnsemblGenomes-Gn:BSU33530" /db_xref="EnsemblGenomes-Tr:CAB15358" /db_xref="GOA:O32223" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="PDB:3GDO" /db_xref="PDB:3GFG" /db_xref="SubtiList:BG14057" /db_xref="UniProtKB/Swiss-Prot:O32223" /translation="MITLLKGRRKVDTIKVGILGYGLSGSVFHGPLLDVLDEYQISKI MTSRTEEVKRDFPDAEVVHELEEITNDPAIELVIVTTPSGLHYEHTMACIQAGKHVVM EKPMTATAEEGETLKRAADEKGVLLSVYHNRRWDNDFLTIKKLISEGSLEDINTYQVS YNRYRPEVQARWREKEGTATGTLYDLGSHIIDQTLHLFGMPKAVTANVMAQRENAETV DYFHLTLDYGKLQAILYGGSIVPANGPRYQIHGKDSSFIKYGIDGQEDALRAGRKPED DSWGADVPEFYGKLTTIRGSDKKTETIPSVNGSYLTYYRKIAESIREGAALPVTAEEG INVIRIIEAAMESSKEKRTIMLEH*" /label="iolW CDS" gene 2962573..2963649 /gene="iolW" /locus_tag="BSU_33530" /old_locus_tag="BSU33530" /label="iolW gene" downshifts 2963636 /Source="Nicolas_upshifts" /id="D1742" /incds=0 /nref=155 /ntot=248 /MaxReadThrough="2.17322" /MaxDrop="6.48885" /score="-5.36701412" /energy="-19.4" /TU="NA" /idTUdmin="U2636" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(2963686..2964321) /gene="azoRB" /locus_tag="BSU_33540" /old_locus_tag="BSU33540" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17284825, 17725564, 18208493" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17284825, 17725564, 18208493; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH:dichloroindophenol oxidoreductase (2-methylhydroquinone resistance)" /protein_id="NP_391234.1" /db_xref="EnsemblGenomes-Gn:BSU33540" /db_xref="EnsemblGenomes-Tr:CAB15359" /db_xref="GOA:O32224" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR023048" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG14058" /db_xref="UniProtKB/Swiss-Prot:O32224" /translation="MAKVLYITAHPHDEATSYSMATGKAFIESYKEANPNDEVVHIDL YKENIPHIDADVFSGWGKLQSGTGFEELSESEKAKVGRLGELSDQFASADKYVFVTPL WNFSFPPVMKAYLDSVAVAGKSFKYTEQGPVGLLTDKKAIHIQARGGYYSEGPAAEME MGHRYIGIMMNFFGVPSFDGIFVEGHNAEPDKAQQIKEDAIARAKEAGKTF*" /label="azoRB CDS" gene complement(2963686..2964321) /gene="azoRB" /locus_tag="BSU_33540" /old_locus_tag="BSU33540" /label="azoRB gene" downshifts complement(2963699) /Source="Nicolas_upshifts" /id="D1743" /incds=0 /nref=211 /ntot=263 /MaxReadThrough="1.58189" /MaxDrop="6.89477" /score="31.0885268" /energy="-15.4" /TU="NA" /idTUdmin="U2637" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2964322..2964419) /Source="Nicolas_S_feature" /locus_tag="new_3446078_3446175_c" /HighExp="Heat, UNK1, G/S, Salt, HiTm, GM-0.1, MG 25, SMM, Etha, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1284" promotor_-10 complement(2964399..2964418) /Source="Nicolas_upshift_promotors" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2964419) /Source="Nicolas_upshifts" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2964432..2964438) /Source="Nicolas_upshift_promotors" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2964481..2966376) /gene="yvaC" /locus_tag="BSU_33550" /old_locus_tag="BSU33550" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12107147, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391235.1" /db_xref="EnsemblGenomes-Gn:BSU33550" /db_xref="EnsemblGenomes-Tr:CAB15360" /db_xref="GOA:O32225" /db_xref="SubtiList:BG14059" /db_xref="UniProtKB/Swiss-Prot:O32225" /translation="MNKTAANNQRIMPIVKDAFRIHANPFPWKKAIGSGFASGFPVLV GALAGHTDYGLIASIGGFVYLYAGGESYKKRALKLLLVSIGIALSFGLGTLLSGMLWM MAAVLGLIGAAAMFIFSALGIQGPAPMFFVLAFLVSSGLPADPSQALFRAGLTFLGGI FAMGIALIGWLWNKHGPEGAVLQKTYHQLAACLSAVGTPGFHNAQHQTVLMLRTARQT VLGKGNRRKKSRHDERFFRLLEKADDIFIAIIHFSAETPDRETAQIEKALRQTGDMLA NARVFNTFQINENESEPRRKLFEEINEVLYIASGRFDKQLDGEPSRLPSSFYFLRNAF DWKSPVLIRALKYGIVLFAADMFALAFGFARSYWIPLSAAAVMLGTTVVFTLHRAIQR SAGTVIGVILAGAILFFKPGGVYIAFCIAALQCLLEMLIVRNYALAVPFLTANALVIT ESMHGGAGAGYFMIARLTDVAVGSVIGLLGTMLLWRRFSTKRLPELVRNVIRLEGQFM EKLLTGQIADEHKLRVSLVRLRDAYDKALGEFPHANADALWPAISGAQHLGYYLLSAQ AHRRPSAPFSDEEINQLRAFFEQAEQSFIMKRMPADIQVPHVPHYPRISKELSALYSG LRTAFEK*" /label="yvaC CDS" gene complement(2964481..2966376) /gene="yvaC" /locus_tag="BSU_33550" /old_locus_tag="BSU33550" /label="yvaC gene" promotor_-10 complement(2966427..2966438) /Source="Nicolas_upshift_promotors" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2966427) /Source="Nicolas_upshifts" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2966453..2966459) /Source="Nicolas_upshift_promotors" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2966526) /Source="Nicolas_upshifts" /id="D1744" /incds=0 /nref=20 /ntot=155 /MaxReadThrough="2.49984" /MaxDrop="4.21522" /score="11.4033831" /energy="-8" /TU="NA" /idTUdmin="U2639" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(2966539..2966940) /gene="yvaD" /locus_tag="BSU_33560" /old_locus_tag="BSU33560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391236.1" /db_xref="EnsemblGenomes-Gn:BSU33560" /db_xref="EnsemblGenomes-Tr:CAB15361" /db_xref="GOA:O32226" /db_xref="InterPro:IPR020348" /db_xref="SubtiList:BG14060" /db_xref="UniProtKB/Swiss-Prot:O32226" /translation="MRYMKLFFLVTDIGFILYWLSAGFSLIPESWAFKHHDHPFMIAW NWSFFPLDILISVTGLYSLYLQRVNRADWKLMALISLVLTCCSGLQALSFWTFSSDFD LVWWLFNGYLLIYPLFFIHLLLKEGRRTKQS*" /label="yvaD CDS" gene complement(2966539..2966940) /gene="yvaD" /locus_tag="BSU_33560" /old_locus_tag="BSU33560" /label="yvaD gene" CDS complement(2966937..2967296) /gene="yvaE" /locus_tag="BSU_33570" /old_locus_tag="BSU33570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11948170, 15849754, 16850406, 19549332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite-efflux transporter" /protein_id="NP_391237.1" /db_xref="EnsemblGenomes-Gn:BSU33570" /db_xref="EnsemblGenomes-Tr:CAB15362" /db_xref="GOA:O32227" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG14061" /db_xref="UniProtKB/Swiss-Prot:O32227" /translation="MNWVFLCLAILFEVAGTVSMKLSSGFTKLIPSLLLIFFYGGSLF FLTLTLKSIDVSVAYAVWSGMGIVLITVVGFLFFQEHVSVMKVISIGLIIAGVVSLNL IEHVAVSEPVHKSGQYK*" /label="yvaE CDS" gene complement(2966937..2967296) /gene="yvaE" /locus_tag="BSU_33570" /old_locus_tag="BSU33570" /label="yvaE gene" CDS complement(2967293..2967865) /gene="yvaF" /locus_tag="BSU_33580" /old_locus_tag="BSU33580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391238.1" /db_xref="EnsemblGenomes-Gn:BSU33580" /db_xref="EnsemblGenomes-Tr:CAB15363" /db_xref="GOA:O32228" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG14062" /db_xref="UniProtKB/Swiss-Prot:O32228" /translation="MDKRILAETFRLIKQKGFSFTMNDLAAALGTSKRTLYAYYSSKD QLVEAVVEQFIAEMKQIERDIYENESLNVLEKVKQMLISLPQGMELLNMGLLNELKKY HYDAWLTLDAFIKEEWAIVLALLNECKQQKRIRNINPDLFVHMYIGSINQVYDPEYPL KHQFTTGEVLESIVDVLFNGITADEEADAT*" /label="yvaF CDS" gene complement(2967293..2967865) /gene="yvaF" /locus_tag="BSU_33580" /old_locus_tag="BSU33580" /label="yvaF gene" promotor_-10 complement(2967903..2967922) /Source="Nicolas_upshift_promotors" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2967908) /Source="Nicolas_upshifts" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2967936..2967943) /Source="Nicolas_upshift_promotors" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2967976..2968770) /gene="yvaG" /locus_tag="BSU_33590" /old_locus_tag="BSU33590" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391239.1" /db_xref="EnsemblGenomes-Gn:BSU33590" /db_xref="EnsemblGenomes-Tr:CAB15364" /db_xref="GOA:O32229" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14063" /db_xref="UniProtKB/Swiss-Prot:O32229" /translation="MKLNLQGKTALVTGSTSGIGKAIASSLAEEGAAVIINGRREEKV NQTIDELKTQHAEAVLYPAAFDLGTEEGCNELFQAYPEVDILVNNLGIFEPAEYFDIP DDEWFRFFEVNIMSGVRLTRRYLHNMIEKKEGRVIFIASEAAIMPSQEMAHYSATKTM QLSISRSLAELATGTNVTVNTVMPGSTLTEGVETMLNSLYPGENLTVQEAEARFMKEN RPTSIIQRLIRPEEIAHFVTFLSSPLSSAINGAALRADGGLVRSVF*" /label="yvaG CDS" gene complement(2967976..2968770) /gene="yvaG" /locus_tag="BSU_33590" /old_locus_tag="BSU33590" /label="yvaG gene" promotor_-10 complement(2968791..2968809) /Source="Nicolas_upshift_promotors" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2968803) /Source="Nicolas_upshifts" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2968824..2968830) /Source="Nicolas_upshift_promotors" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2968836..2968855) /Source="Nicolas_upshift_promotors" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2968847) /Source="Nicolas_upshifts" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2968849..2968914) /Source="Nicolas_S_feature" /locus_tag="new_3450605_3450670_c" /HighExp="H2O2, Heat, Diami, G180, Paraq, dia15, Oxctl, BMM, G135, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.47, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="0.996, 1" /label="S1285" promotor_-35 complement(2968869..2968876) /Source="Nicolas_upshift_promotors" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA complement(2968956..2969315) /gene="ssrA" /locus_tag="BSU_misc_RNA_55" /product="transfer-messenger RNA (tmRNA, 10Sa RNA)" /experiment="publication(s) with functional evidences, PMID:11395451, 11918677, 14766921, 17369301, 18673456" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11395451, 11918677, 14766921, 17369301, 18673456" /label="ssrA RNA" gene complement(2968956..2969315) /gene="ssrA" /locus_tag="BSU_misc_RNA_55" /label="ssrA gene" downshifts complement(2968959) /Source="Nicolas_upshifts" /id="D1745" /incds=0 /nref=260 /ntot=272 /MaxReadThrough="4.32959" /MaxDrop="9.81359" /score="26.7868133" /energy="-15.8" /TU="U2642,U2644" /idTUdmin="U2643" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2969299..2969307) /Source="Nicolas_upshift_promotors" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2969309) /Source="Nicolas_upshifts" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2969322..2969327) /Source="Nicolas_upshift_promotors" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2969367..2969386) /Source="Nicolas_upshift_promotors" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2969375) /Source="Nicolas_upshifts" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2969377..2969441) /Source="Nicolas_S_feature" /locus_tag="new_3451133_3451197_c" /HighExp="Etha, C90, dia5, dia15, Diami, T0.0H, T-0.40H, T-1.40H, LPhT, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.997, 0.996, 1" /TUlongSig="SigB, SigA" /TUlongPSig="0.999, 0.753" /label="S1286" promotor_-35 complement(2969399..2969403) /Source="Nicolas_upshift_promotors" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2969441) /Source="Nicolas_upshifts" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="upshifts" promotor_-10 complement(2969442..2969461) /Source="Nicolas_upshift_promotors" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="promotor_-10" promotor_-35 complement(2969476..2969483) /Source="Nicolas_upshift_promotors" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="promotor_-35" CDS complement(2969492..2969962) /gene="smpB" /locus_tag="BSU_33600" /old_locus_tag="BSU33600" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10947848, 11395451, 11918677, 12682299, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10947848, 11395451, 11918677, 12682299, 26735940; Product type f: factor" /codon_start=1 /transl_table=11 /product="tmRNA-binding protein" /protein_id="NP_391240.1" /db_xref="EnsemblGenomes-Gn:BSU33600" /db_xref="EnsemblGenomes-Tr:CAB15365" /db_xref="GOA:O32230" /db_xref="InterPro:IPR000037" /db_xref="InterPro:IPR020081" /db_xref="InterPro:IPR023620" /db_xref="SubtiList:BG14064" /db_xref="UniProtKB/Swiss-Prot:O32230" /translation="MPKGSGKVLSQNKKANHDYFIEETYETGIVLQGTEIKSIRAGRV NLKDSFAKIERGEVFLHNMHVSPYEQGNRYNHDPLRTRKLLMHRKEINKLIGLTKEKG YSLVPLKLYLKNGFAKVLLGLGKGKKNYDKREDLKRKDAKREIERAFRDSQKGF*" /label="smpB CDS" gene complement(2969492..2969962) /gene="smpB" /locus_tag="BSU_33600" /old_locus_tag="BSU33600" /label="smpB gene" promotor_no_box 2969789..2969889 /Source="Nicolas_upshift_promotors" /id="U2645" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.94005994005994" /psig="0.018981018981019" /xcortree=38 /SigmaFactorBS="cacttctccccgttcgattttggcgaaggaatccttaaggtt tacgcggccggcgcgaatcgatttgatttcggttccttgcagaacgatgcctgtttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2969849 /Source="Nicolas_upshifts" /id="U2645" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.94005994005994" /psig="0.018981018981019" /xcortree=38 /SigmaFactorBS="cacttctccccgttcgattttggcgaaggaatccttaaggtt tacgcggccggcgcgaatcgatttgatttcggttccttgcagaacgatgcctgtttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2969959 /Source="Nicolas_upshifts" /id="D1746" /incds=0 /nref=2 /ntot=105 /MaxReadThrough="0.62459" /MaxDrop="3.18501" /score="-9.3042809" /energy="-3.3" /TU="NA" /idTUdmin="U2647" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2970007..2970026) /Source="Nicolas_upshift_promotors" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-10" upshifts complement(2970013) /Source="Nicolas_upshifts" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="upshifts" S_feature complement(2970015..2970106) /Source="Nicolas_S_feature" /locus_tag="new_3451771_3451862_c" /HighExp="Etha, S8, Cold, S7, G135, G180, G150, H2O2, M9-stat, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA" /TUlongPSig="0.753" /label="S1287" promotor_-35 complement(2970042..2970045) /Source="Nicolas_upshift_promotors" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-35" CDS complement(2970107..2972446) /gene="rnr" /locus_tag="BSU_33610" /old_locus_tag="BSU33610" /EC_number="3.1.13.1" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12399495, 15805522, 15983136, 19215769, 22333191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399495, 15805522, 15983136, 19215769, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease R" /protein_id="NP_391241.1" /db_xref="EnsemblGenomes-Gn:BSU33610" /db_xref="EnsemblGenomes-Tr:CAB15366" /db_xref="GOA:O32231" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004476" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR011805" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013223" /db_xref="InterPro:IPR022966" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14065" /db_xref="UniProtKB/Swiss-Prot:O32231" /translation="MEKEAFMEKLLSFMKEEAYKPLTVQELEEMLNITEAEEFKELVK ALVALEEKGLIVRTRSDRYGIPEKMNLIKGKISAHAKGFAFLLPEDTSLSDVFIPPNE LNTAMNGDIVMVRLNSQSSGSRQEGTVIRILERAIQRVVGTYTETRNFGFVIPDDKKI TSDIFIPKNGKNGAAEGHKVVVKLTSYPEGRMNAEGEVETILGHKNDPGIDILSVIHK HGLPGEFPADAMEQASSTPDTIDEKDLKDRRDLRDQVIVTIDGADAKDLDDAVTVTKL DDGSYKLGVHIADVSHYVTENSPIDKEALERGTSVYLVDRVIPMIPHRLSNGICSLNP KVDRLTLSCEMTINSQGQVTEHEIFQSVIKTTERMTYSDVNKILVDDDEELKQKYEPL VPMFKDMERLAQILRDKRMDRGAVDFDFKEAKVLVDDEGAVKDVVIRERSVAEKLIEE FMLVANETVAEHFHWMNVPFIYRIHEEPNAEKLQKFLEFVTTFGYVVKGTAGNIHPRA LQSILDAVRDRPEETVISTVMLRSMKQAKYDPQSLGHFGLSTEFYTHFTSPIRRYPDL IVHRLIRTYLINGKVDEATQEKWAERLPDIAEHTSSMERRAVDAERETDDLKKAEYML DKIGEEFDGMISSVTNFGMFVELPNTIEGLVHVSFMTDDYYRFDEQHFAMIGERTGNV FRIGDEITVKVVDVNKDERNIDFEIVGMKGTPRRPRELDSSRSRKRGKPARKRVQSTN TPVSPAPSEEKGEWFTKPKKKKKKRGFQNAPKQKRKKKK*" /label="rnr CDS" gene complement(2970107..2972446) /gene="rnr" /locus_tag="BSU_33610" /old_locus_tag="BSU33610" /label="rnr gene" promotor_-35 2971207..2971210 /Source="Nicolas_upshift_promotors" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2971226..2971229 /Source="Nicolas_upshift_promotors" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2971235 /Source="Nicolas_upshifts" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2972465..2973205) /gene="estA" /locus_tag="BSU_33620" /old_locus_tag="BSU33620" /EC_number="3.1.1.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1369099, 17369301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxylesterase" /protein_id="NP_391242.2" /db_xref="EnsemblGenomes-Gn:BSU33620" /db_xref="EnsemblGenomes-Tr:CAB15367" /db_xref="GOA:O32232" /db_xref="InterPro:IPR012354" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG14066" /db_xref="UniProtKB/Swiss-Prot:O32232" /translation="MKVVTPKPFTFKGGDKAVLLLHGFTGNTADVRMLGRYLNERGYT CHAPQYEGHGVPPEELVHTGPEDWWKNVMDGYEYLKSEGYESIAACGLSLGGVFSLKL GYTVPIKGIVPMCAPMHIKSEEVMYQGVLSYARNYKKFEGKSPEQIEEEMKEFEKTPM NTLKALQDLIADVRNNVDMIYSPTFVVQARHDHMINTESANIIYNEVETDDKQLKWYE ESGHVITLDKERDLVHQDVYEFLEKLDW*" /label="estA CDS" gene complement(2972465..2973205) /gene="estA" /locus_tag="BSU_33620" /old_locus_tag="BSU33620" /label="estA gene" promotor_-10 complement(2972861..2972879) /Source="Nicolas_upshift_promotors" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="promotor_-10" upshifts complement(2972873) /Source="Nicolas_upshifts" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="upshifts" promotor_-35 complement(2972894..2972900) /Source="Nicolas_upshift_promotors" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="promotor_-35" misc_feature complement(2973233..2973251) /Source="Nicolas_upshift_promotors" /id="U2649" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.376623376623377" /psig="0.753246753246753" /xcortree=634 /SigmaFactorBS="gtcaggcctttttcacgtttctggatgatattcaaaacgttt ttttctgattaaacTGTGGAAAACTAAAATGATcgtgcagatagaaagggagacatga g" /listShort="yvaK, rnr" /listLong="S1287, smpB, S1286, ssrA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2973247) /Source="Nicolas_upshifts" /id="U2649" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.376623376623377" /psig="0.753246753246753" /xcortree=634 /SigmaFactorBS="gtcaggcctttttcacgtttctggatgatattcaaaacgttt ttttctgattaaacTGTGGAAAACTAAAATGATcgtgcagatagaaagggagacatga g" /listShort="yvaK, rnr" /listLong="S1287, smpB, S1286, ssrA" /label="upshifts" downshifts complement(2973335) /Source="Nicolas_upshifts" /id="D1747" /incds=0 /nref=30 /ntot=212 /MaxReadThrough="6.16751" /MaxDrop="5.2246" /score="-4.14736839" /energy="-9.1" /TU="U2650" /idTUdmin="U2649" /TUdmin="-3234" /isTUend="FALSE" /label="downshifts" CDS complement(2973337..2973567) /gene="secG" /locus_tag="BSU_33630" /old_locus_tag="BSU33630" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10074070, 10644701, 16243836" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10074070, 10644701, 16243836; Product type f: factor" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_391243.1" /db_xref="EnsemblGenomes-Gn:BSU33630" /db_xref="EnsemblGenomes-Tr:CAB15368" /db_xref="GOA:O32233" /db_xref="InterPro:IPR004692" /db_xref="SubtiList:BG14067" /db_xref="UniProtKB/Swiss-Prot:O32233" /translation="MHAVLITLLVIVSIALIIVVLLQSSKSAGLSGAISGGAEQLFGK QKARGLDLILHRITVVLAVLFFVLTIALAYIL*" /label="secG CDS" gene complement(2973337..2973567) /gene="secG" /locus_tag="BSU_33630" /old_locus_tag="BSU33630" /label="secG gene" promotor_-10 complement(2973597..2973616) /Source="Nicolas_upshift_promotors" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-10" upshifts complement(2973618) /Source="Nicolas_upshifts" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="upshifts" promotor_-35 complement(2973631..2973634) /Source="Nicolas_upshift_promotors" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-35" promotor_-35 2973656..2973662 /Source="Nicolas_upshift_promotors" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2973676..2973687 /Source="Nicolas_upshift_promotors" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2973677 /Source="Nicolas_upshifts" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="upshifts" CDS 2973716..2974486 /gene="yvaM" /locus_tag="BSU_33640" /old_locus_tag="BSU33640" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391244.1" /db_xref="EnsemblGenomes-Gn:BSU33640" /db_xref="EnsemblGenomes-Tr:CAB15369" /db_xref="GOA:O32234" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG14068" /db_xref="UniProtKB/Swiss-Prot:O32234" /translation="MPLISIDSRKHLFYEEYGQGIPIIFIHPPGMGRKVFYYQRLLSK HFRVIFPDLSGHGDSDHIDQPASISYYANEIAQFMDALHIDKAVLFGYSAGGLIAQHI GFTRPDKVSHLILSGAYPAVHNVIGQKLHKLGMYLLEKNPGLLMKILAGSHTKDRQLR SILTDHMKKADQAHWHQYYLDSLGYNCIEQLPRLEMPMLFMYGGLRDWTFTNAGYYRR SCRHAEFFRLEYQGHQLPTKQWKTCNELVTGFVLTHHS*" /label="yvaM CDS" gene 2973716..2974486 /gene="yvaM" /locus_tag="BSU_33640" /old_locus_tag="BSU33640" /label="yvaM gene" promotor_-35 2973738..2973746 /Source="Nicolas_upshift_promotors" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2973757..2973775 /Source="Nicolas_upshift_promotors" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2973787 /Source="Nicolas_upshifts" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2974526..2974759) /gene="yvzC" /locus_tag="BSU_33650" /old_locus_tag="BSU33650" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative phage-like transcriptional regulator" /protein_id="NP_391245.1" /db_xref="EnsemblGenomes-Gn:BSU33650" /db_xref="EnsemblGenomes-Tr:CAB15370" /db_xref="GOA:O32235" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG14159" /db_xref="UniProtKB/Swiss-Prot:O32235" /translation="MPVEKIQIRRDYVLQYMVNNDYSLNQLALEIGVSPATLSRVLNG ERRPGQLVIGKMLHYFNLKFEDLFYYDFVDKSQ*" /label="yvzC CDS" gene complement(2974526..2974759) /gene="yvzC" /locus_tag="BSU_33650" /old_locus_tag="BSU33650" /label="yvzC gene" promotor_-35 2974850..2974857 /Source="Nicolas_upshift_promotors" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="promotor_-35" upshifts 2974865 /Source="Nicolas_upshifts" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="upshifts" promotor_-10 2974869..2974888 /Source="Nicolas_upshift_promotors" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="promotor_-10" CDS 2974911..2975318 /gene="rghRA" /locus_tag="BSU_33660" /old_locus_tag="BSU33660" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16553878, 17227471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor" /protein_id="NP_391246.1" /db_xref="EnsemblGenomes-Gn:BSU33660" /db_xref="EnsemblGenomes-Tr:CAB15371" /db_xref="GOA:O32236" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR016759" /db_xref="SubtiList:BG14069" /db_xref="UniProtKB/Swiss-Prot:O32236" /translation="MESFGEQLRALREERKLTVNQLATYSGVSAAGISRIENGKRGVP KPATIKKLAEALKIPYEGLMYKAGYIEEVHEARAPYETKCKLLEKAEAYDLKNLALLE NEKWQYLNKEDLLMLDHYFSFISDEAKKRSADD*" /label="rghRA CDS" gene 2974911..2975318 /gene="rghRA" /locus_tag="BSU_33660" /old_locus_tag="BSU33660" /label="rghRA gene" CDS 2975348..2975767 /gene="rghRB" /locus_tag="BSU_33670" /old_locus_tag="BSU33670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative phage-like transcriptional repressor" /protein_id="NP_391247.1" /db_xref="EnsemblGenomes-Gn:BSU33670" /db_xref="EnsemblGenomes-Tr:CAB15372" /db_xref="GOA:O32237" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR016759" /db_xref="SubtiList:BG14070" /db_xref="UniProtKB/Swiss-Prot:O32237" /translation="MSPFGQQLRELRRARKLTVNQLAVYSGISSATISKIENGKRGTP KPATIKKLAAVLKVPYENLMAAAGHIQAFPEEIREASEGYQSVYEIYQTAVTRGAEHL PIFNSQKWEHLSKQDIENLSKYFDFLSSEAKKRASSS*" /label="rghRB CDS" gene 2975348..2975767 /gene="rghRB" /locus_tag="BSU_33670" /old_locus_tag="BSU33670" /label="rghRB gene" promotor_-35 2975805..2975812 /Source="Nicolas_upshift_promotors" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2975826..2975845 /Source="Nicolas_upshift_promotors" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2975833 /Source="Nicolas_upshifts" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="upshifts" CDS 2975859..2976185 /gene="catR" /locus_tag="BSU_33680" /old_locus_tag="BSU33680" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:20639328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20639328; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of catechol dioxygenase" /protein_id="NP_391248.2" /db_xref="EnsemblGenomes-Gn:BSU33680" /db_xref="EnsemblGenomes-Tr:CAB15373" /db_xref="GOA:O32238" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14071" /db_xref="UniProtKB/Swiss-Prot:O32238" /translation="MNQSEMCPRFEKAVDILSKRWVALIVFQLLNGSQRFSEIEAALP NLSGRVLSERLKELELEGVVKRDVIPETPVRIEYSLTDKGKALAPILGEISKWATEWI DPSFLD*" /label="catR CDS" gene 2975859..2976185 /gene="catR" /locus_tag="BSU_33680" /old_locus_tag="BSU33680" /label="catR gene" S_feature 2976186..2976270 /Source="Nicolas_S_feature" /locus_tag="new_3457942_3458026" /HighExp="Cold, H2O2, Diami, LBGstat, LPhT, dia15, G180, Paraq, Etha, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.985" /label="S1288" promotor_-35 2976241..2976248 /Source="Nicolas_upshift_promotors" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2976261..2976279 /Source="Nicolas_upshift_promotors" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2976272 /Source="Nicolas_upshifts" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="upshifts" CDS 2976310..2978010 /gene="yvaQ" /locus_tag="BSU_33690" /old_locus_tag="BSU33690" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8188684, 11872722, 27899502; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative methyl-accepting transducer" /protein_id="NP_391249.1" /db_xref="EnsemblGenomes-Gn:BSU33690" /db_xref="EnsemblGenomes-Tr:CAB15374" /db_xref="GOA:O32239" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR024478" /db_xref="InterPro:IPR035440" /db_xref="SubtiList:BG14072" /db_xref="UniProtKB/Swiss-Prot:O32239" /translation="MRLTISRKFSLVFLTLILINLLVGGIGVLNMQHIIQKTDEINTK WIDGIKGITSINYVTEHLSSKEKDFLIYTDKSKMDTLDQEMNQIMEDINQKLDNYEKT ISTDKEQKLFEQLQTKVNTYMDIHAQIIESGRTNDMDKARGLLVQTEASFEDMKKTIT QLVDLNQEGSNTAVKETKAVYHKGLIYTALLVAASILISIFIWLYITRNIVKPIIRMK ESANHIAEGDLSNDMEALNSKDELGDLNEALQKMVGNLRDIVGYSKDISSRVLSSSQV LATATNETRSGSKHITETMNEMAEGSEQQAQDAVTIAESMNEFTESIDKAYNHGITIS DTSQNVLELAVSGNENMATSLQQMKTIHHIVEEAVHKVRSLEQHSQDINKLVQVINGI AEQTNLLSLNAAIEAARAGESGKGFAVVAEEVRKLADGVSDSVQDITRIVNGTQQEIH TVITYLESSFTEVEKGTENLTDTGQAMQHIKQSVTHVADSIKEVTDGLKQLTNQSITI NQSIENIASVSEESAAGIEETFSITEQSAHSMDQVLLNAEELEQLANELNEKMGQFTI *" /label="yvaQ CDS" gene 2976310..2978010 /gene="yvaQ" /locus_tag="BSU_33690" /old_locus_tag="BSU33690" /label="yvaQ gene" S_feature complement(2977026..2978019) /Source="Nicolas_S_feature" /locus_tag="new_3458782_3459775_c" /HighExp="S6, S5, S7, C30, S8, S4, S3, LoTm, BT, B36" /AntisenseName="yvaQ" /AntisenseCor="-0.38660715434937498" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1289" downshifts 2977988 /Source="Nicolas_upshifts" /id="D1748" /incds=0 /nref=30 /ntot=152 /MaxReadThrough="1.43789" /MaxDrop="3.86744" /score="26.1532813" /energy="-12.2" /TU="NA" /idTUdmin="U2655" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2978050..2978730) /gene="opuBD" /locus_tag="BSU_33700" /old_locus_tag="BSU33700" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (permease)" /protein_id="NP_391250.1" /db_xref="EnsemblGenomes-Gn:BSU33700" /db_xref="EnsemblGenomes-Tr:CAB15375" /db_xref="GOA:P39775" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12636" /db_xref="UniProtKB/Swiss-Prot:P39775" /translation="MNVLEQLMTYYAQNGSYVMDEFGRHFLMSAYGVLFAAVVGVPAG ILIAHFRRLSAWVFAVTNVIQTIPALAMLAVLMLVMGLGANTVILSLFLYSLLPIIRN TYTGIISIEHAYLESGKAMGMTKFQVLRMVELPLALSVIMAGLRTALVIAIGITAIGT FVGAGGLGDMIVRGSNATNGTAIILAGAIPTAVMAVGADLLMAWLERALSPVKKKRTG AKHVQSAA*" /label="opuBD CDS" gene complement(2978050..2978730) /gene="opuBD" /locus_tag="BSU_33700" /old_locus_tag="BSU33700" /label="opuBD gene" downshifts complement(2978064) /Source="Nicolas_upshifts" /id="D1749" /incds=0 /nref=119 /ntot=171 /MaxReadThrough="3.12805" /MaxDrop="5.39624" /score="35.0134287" /energy="-12.2" /TU="NA" /idTUdmin="U2657" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2978424..2978430 /Source="Nicolas_upshift_promotors" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2978445..2978463 /Source="Nicolas_upshift_promotors" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2978450..2981201 /Source="Nicolas_S_feature" /locus_tag="new_3460206_3462957" /HighExp="Sw, M9-stat, B60, Salt, LoTm, T0.30H, BC, Gly, B36, T1.0H" /AntisenseName="opuBC" /AntisenseCor="-0.13125567572652899" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1290" upshifts 2978450 /Source="Nicolas_upshifts" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2978747..2979667) /gene="opuBC" /locus_tag="BSU_33710" /old_locus_tag="BSU33710" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (choline-binding lipoprotein)" /protein_id="NP_391251.1" /db_xref="EnsemblGenomes-Gn:BSU33710" /db_xref="EnsemblGenomes-Tr:CAB15376" /db_xref="GOA:Q45462" /db_xref="InterPro:IPR007210" /db_xref="PDB:3R6U" /db_xref="SubtiList:BG12635" /db_xref="UniProtKB/Swiss-Prot:Q45462" /translation="MKRKYLKLMIGLALAATLTLSGCSLPGLSAAADQTIKIGAQSMS ESEIIASMLGQLIEHHTDLKTTTIKNLGSNAVQQQALMNGEIDIAATRYTGDALTGTL RMEPEKDPDKALALTQREFKKRYDLKWYDSYGFDNTYAFTVSKELADQYHLETVSDVK KWAPQLKLGVDNYWMKLKGNGYQDFTKTYGMTFGGTYPMQIGLVYDAVKSGKMDIVLA YSTDGRIKSYGLKMLKDDKQFFPPYDCSPVVPEKVLKEHPELEGIIKKMLGKIDTATM QELNYEVDGNLKEPSVVAKEYLEKHRYFES*" /label="opuBC CDS" gene complement(2978747..2979667) /gene="opuBC" /locus_tag="BSU_33710" /old_locus_tag="BSU33710" /label="opuBC gene" CDS complement(2979679..2980332) /gene="opuBB" /locus_tag="BSU_33720" /old_locus_tag="BSU33720" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (permease)" /protein_id="NP_391252.1" /db_xref="EnsemblGenomes-Gn:BSU33720" /db_xref="EnsemblGenomes-Tr:CAB15377" /db_xref="GOA:Q45461" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12634" /db_xref="UniProtKB/Swiss-Prot:Q45461" /translation="MHHIVQFLQTNGGELLYKTYEHITISLIAVILGVLVAVPLGVVL TRMKKGAGTIIGIVNIIQTLPSLAILAFFIPLLGVGKVPAIVALFFYSVLPILRNTYT GIRGVNKNLLESGKGIGMTPAEQVRLVELPLAAPVIMAGIRTSTIYLIGWATLASFIG GGGLGDYIFIGLNLYQPEYIIGGAVPVTILAIVIDYVLAVAERKLTPAGMQRLKELS* " /label="opuBB CDS" gene complement(2979679..2980332) /gene="opuBB" /locus_tag="BSU_33720" /old_locus_tag="BSU33720" /label="opuBB gene" CDS complement(2980349..2981494) /gene="opuBA" /locus_tag="BSU_33730" /old_locus_tag="BSU33730" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 18321243, 21658392" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 18321243, 21658392; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (ATP-binding protein)" /protein_id="NP_391253.1" /db_xref="EnsemblGenomes-Gn:BSU33730" /db_xref="EnsemblGenomes-Tr:CAB15378" /db_xref="GOA:Q45460" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12633" /db_xref="UniProtKB/Swiss-Prot:Q45460" /translation="MLTLENVSKTYKGGKKAVNNVNLKIAKGEFICFIGPSGCGKTTT MKMINRLIEPSAGKIFIDGENIMDQDPVELRRKIGYVIQQIGLFPHMTIQQNISLVPK LLKWPEQQRKERARELLKLVDMGPEYVDRYPHELSGGQQQRIGVLRALAAEPPLILMD EPFGALDPITRDSLQEEFKKLQKTLHKTIVFVTHDMDEAIKLADRIVILKAGEIVQVG TPDDILRNPADEFVEEFIGKERLIQSSSPDVERVDQIMNTQPVTITADKTLSEAIQLM RQERVDSLLVVNDERVLQGYVDVEIIDQCRKKANLVSEVLHEDIYTVLGGTLLRDTVR KILKRGVKYVPVVDEDRRLIGIVTRASLVDIVYDSLWGEEKQLAALS*" /label="opuBA CDS" gene complement(2980349..2981494) /gene="opuBA" /locus_tag="BSU_33730" /old_locus_tag="BSU33730" /label="opuBA gene" S_feature complement(2981495..2981562) /Source="Nicolas_S_feature" /locus_tag="new_3463251_3463318_c" /HighExp="T5.0H, T3.30H, T3.0H, T-5.40H, T4.0H, T-0.40H, T-1.40H, T2.30H, T-3.40H, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1291" upshifts complement(2981562) /Source="Nicolas_upshifts" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2981563..2981582) /Source="Nicolas_upshift_promotors" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2981593..2981597 /Source="Nicolas_upshift_promotors" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2981597..2981600) /Source="Nicolas_upshift_promotors" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2981613..2981631 /Source="Nicolas_upshift_promotors" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2981618 /Source="Nicolas_upshifts" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2981713..2981717 /Source="Nicolas_upshift_promotors" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2981733..2981752 /Source="Nicolas_upshift_promotors" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2981736 /Source="Nicolas_upshifts" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="upshifts" CDS 2981778..2982311 /gene="yvaV" /locus_tag="BSU_33740" /old_locus_tag="BSU33740" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (controlling choline uptake)" /protein_id="NP_391254.2" /db_xref="EnsemblGenomes-Gn:BSU33740" /db_xref="EnsemblGenomes-Tr:CAB15379" /db_xref="GOA:C0SPB8" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14073" /db_xref="UniProtKB/Swiss-Prot:C0SPB8" /translation="MEKDPLTIIEQAEDHFIERIAENMHAFGMPSTVGRVLGIIYMNR KPMTLTELSEATGMSKTRMSQVVREMLDANIAEKVFEKGVRKDLYEVEQDYYQTFITL FSATWSKVVSKNKMMHKKLNRELLSVLDEELTPEAEEKVNELLKELKEWLDYYNWLSR LIEFFESEDIFKYVPKP*" /label="yvaV CDS" gene 2981778..2982311 /gene="yvaV" /locus_tag="BSU_33740" /old_locus_tag="BSU33740" /label="yvaV gene" S_feature complement(2981978..>2982377) /Source="Nicolas_S_feature" /locus_tag="new_3463734_3464253_c" /HighExp="S8, Cold, C30, GM 25, GM 60, BC, T-4.40H, M/G, GM-0.1, MG 120" /AntisenseName="yvaV" /AntisenseCor="-7.6123637680436104E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.503, 1, 0.758" /TUlongSig="NA" /TUlongPSig="NA" /label="S1292" downshifts 2982300 /Source="Nicolas_upshifts" /id="D1750" /incds=0 /nref=51 /ntot=161 /MaxReadThrough="2.68472" /MaxDrop="4.69377" /score="-3.5823381" /energy="-8.6" /TU="NA" /idTUdmin="U2659" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR join(2982377,2982384) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs14" N_region 2982378..2982383 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs14" S_feature <2982384..2982459 /Source="Nicolas_S_feature" /locus_tag="new_3466412_3467550" /HighExp="Pyr, S8, nit, C30, GM 150, M9-stat, S7, S2, G/S, S1" /AntisenseName="sdpI" /AntisenseCor="-7.9710115369408502E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.636, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1297" S_feature complement(<2982384..2982450) /Source="Nicolas_S_feature" /locus_tag="new_3467393_3467541_c" /HighExp="Salt, B36, Gly, B60, LoTm, S8, GM 5, MG 25, Cold, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1298" CDS complement(2982455..2983144) /gene="opuCD" /locus_tag="BSU_33800" /old_locus_tag="BSU33800" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406, 28256787; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (promiscuous permease)" /protein_id="NP_391260.1" /db_xref="EnsemblGenomes-Gn:BSU33800" /db_xref="EnsemblGenomes-Tr:CAB15385" /db_xref="GOA:O34742" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12640" /db_xref="UniProtKB/Swiss-Prot:O34742" /translation="MEVLQQLGTYYSQNGGYVLQEFYRHFLMSVYGVLFAAIVGIPLG ILIARYRRLSGWVFAVTNVIQTIPALAMLAVLMLVMGLGANTVILSLFLYSLLPIIRN TYTGIISIEHAYLESGKAMGMTKFQVLRMVELPLALSVIMAGLRTALVIAIGITAIGT FVGAGGLGDIIVRGSNATNGTAIILAGAIPTALMAVIADLVMGWLERALSPIKKKKGN FIIADRKTTSI*" /label="opuCD CDS" gene complement(2982455..2983144) /gene="opuCD" /locus_tag="BSU_33800" /old_locus_tag="BSU33800" /label="opuCD gene" downshifts complement(2982495) /Source="Nicolas_upshifts" /id="D1757" /incds=0 /nref=95 /ntot=199 /MaxReadThrough="5.55394" /MaxDrop="6.7177" /score="8.72167152" /energy="-11.6" /TU="U2667" /idTUdmin="U2667" /TUdmin="-1166" /isTUend="FALSE" /label="downshifts" promotor_-35 2983087..2983095 /Source="Nicolas_upshift_promotors" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2983109..2983128 /Source="Nicolas_upshift_promotors" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2983123 /Source="Nicolas_upshifts" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2983162..2984073) /gene="opuCC" /locus_tag="BSU_33810" /old_locus_tag="BSU33810" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 28256787; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (osmoprotectant-binding lipoprotein)" /protein_id="NP_391261.1" /db_xref="EnsemblGenomes-Gn:BSU33810" /db_xref="EnsemblGenomes-Tr:CAB15386" /db_xref="GOA:O32243" /db_xref="InterPro:IPR007210" /db_xref="PDB:3PPN" /db_xref="PDB:3PPO" /db_xref="PDB:3PPP" /db_xref="PDB:3PPQ" /db_xref="PDB:3PPR" /db_xref="SubtiList:BG12639" /db_xref="UniProtKB/Swiss-Prot:O32243" /translation="MTKIKWLGAFALVFVMLLGGCSLPGLGGASDDTIKIGAQSMTES EIVANMIAQLIEHDTDLNTALVKNLGSNYVQHQAMLGGDIDISATRYSGTDLTSTLGK EAEKDPKKALNIVQNEFQKRFSYKWFDSYGFDNTYAFTVTKKFAEKEHINTVSDLKKN ASQYKLGVDNAWLKRKGDGYKGFVSTYGFEFGTTYPMQIGLVYDAVKNGKMDAVLAYS TDGRIKAYDLKILKDDKRFFPPYDCSPVIPEKVLKEHPELEGVINKLIGQIDTETMQE LNYEVDGKLKEPSVVAKEFLEKHHYFD*" /label="opuCC CDS" gene complement(2983162..2984073) /gene="opuCC" /locus_tag="BSU_33810" /old_locus_tag="BSU33810" /label="opuCC gene" CDS complement(2984093..2984746) /gene="opuCB" /locus_tag="BSU_33820" /old_locus_tag="BSU33820" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406, 28256787; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (promiscuous permease)" /protein_id="NP_391262.1" /db_xref="EnsemblGenomes-Gn:BSU33820" /db_xref="EnsemblGenomes-Tr:CAB15387" /db_xref="GOA:O34878" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12638" /db_xref="UniProtKB/Swiss-Prot:O34878" /translation="MNQMMTFLQTNGGELLYKTGEHLYISLIAVVLGIIVAVPLGVAL TRMKKGAGAVIGFVNIVQTLPSLAILAFFIPLLGVGKVPAIVALFFYSVLPILRNTYT GIKGVNKNLLESGKGIGMTGWEQIRLVEIPLAIPIIMAGIRTSTIYLIGWATLASFIG GGGLGDYIFIGLNLYQPEYIIGGAVPVTILAIIIDYVLAVTERKVTPKGLQGMKEVS* " /label="opuCB CDS" gene complement(2984093..2984746) /gene="opuCB" /locus_tag="BSU_33820" /old_locus_tag="BSU33820" /label="opuCB gene" CDS complement(2984769..2985911) /gene="opuCA" /locus_tag="BSU_33830" /old_locus_tag="BSU33830" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10216873, 9925583, 21658392, 27378384, 27683249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216873, 9925583, 21658392, 27378384, 27683249; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (ATP-binding protein)" /protein_id="NP_391263.1" /db_xref="EnsemblGenomes-Gn:BSU33830" /db_xref="EnsemblGenomes-Tr:CAB15388" /db_xref="GOA:O34992" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12637" /db_xref="UniProtKB/Swiss-Prot:O34992" /translation="MLKLEQVSKVYKGGKKAVNSIDLDIAKGEFICFIGPSGCGKTTT MKMINRLIEPSSGRIFIDGENIMEQDPVELRRKIGYVIQQIGLFPHMTIQQNISLVPK LLKWPEEKRKERARELLKLVDMGPEYLDRYPHELSGGQQQRIGVLRALAAEPPLILMD EPFGALDPITRDSLQEEFKKLQRTLNKTIVFVTHDMDEAIKLADRIVILKAGEIVQVG TPDEILRNPANEFVEEFIGKERLIQSRPDIERVEQMMNRTPVTVSADKTLSQAIQLMR EKRVDSLLVVDRQNVLKGYVDVEMIDQNRKKASIVGDVYRSDIYTVQKGALLRDTVRK ILKQGIKYVPVVDEQNHLAGIVTRASLVDIVYDSIWGDEENQLMTI*" /label="opuCA CDS" gene complement(2984769..2985911) /gene="opuCA" /locus_tag="BSU_33830" /old_locus_tag="BSU33830" /label="opuCA gene" promotor_-10 complement(2985955..2985974) /Source="Nicolas_upshift_promotors" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="promotor_-10" upshifts complement(2985970) /Source="Nicolas_upshifts" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="upshifts" promotor_-35 complement(2985989..2985992) /Source="Nicolas_upshift_promotors" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="promotor_-35" promotor_-35 2986108..2986115 /Source="Nicolas_upshift_promotors" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2986128..2986147 /Source="Nicolas_upshift_promotors" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2986139 /Source="Nicolas_upshifts" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="upshifts" CDS 2986175..2986732 /gene="opcR" /locus_tag="BSU_33840" /old_locus_tag="BSU33840" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23960087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23960087; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative transcriptional regulator of choline uptake systems" /protein_id="NP_391264.1" /db_xref="EnsemblGenomes-Gn:BSU33840" /db_xref="EnsemblGenomes-Tr:CAB15389" /db_xref="GOA:O34709" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14079" /db_xref="UniProtKB/Swiss-Prot:O34709" /translation="MKKTALDIIEHAEEHLIEKIAENMHTFGMPSTVGRVLGIIYMNR KPMTLSELSEATGMSKTRMSQVVREMIDANIAEKVFEKGVRKDLYDVEQDYYQTFISL FAANWTKVVSKNKVLYKKLNRELSDLLQRDGLTPEAEEKVNQLLNELKEWLHYYDWLS RLIEFFESEEVFRYVPKTKECSSLK*" /label="opcR CDS" gene 2986175..2986732 /gene="opcR" /locus_tag="BSU_33840" /old_locus_tag="BSU33840" /label="opcR gene" S_feature 2986733..2987497 /Source="Nicolas_S_feature" /locus_tag="new_3471824_3472588" /HighExp="HiOs, GM 5, GM 10, Salt, MG 15, MG 10, MG 25, T0.0H, T-2.40H, GM 45" /AntisenseName="yvbG" /AntisenseCor="-0.14921239095219299" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1299" CDS complement(2986750..2987385) /gene="yvbG" /locus_tag="BSU_33850" /old_locus_tag="BSU33850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391265.1" /db_xref="EnsemblGenomes-Gn:BSU33850" /db_xref="EnsemblGenomes-Tr:CAB15390" /db_xref="GOA:O32244" /db_xref="InterPro:IPR002771" /db_xref="SubtiList:BG14080" /db_xref="UniProtKB/Swiss-Prot:O32244" /translation="MMFSFIVHVFISLFAVSNPIGNVPIFLTLTEGYTAAERKAIARK AAILSFFILAAFLVFGHLIFKLFDINIHALRVAGGIFIFGIAYNLLNAKESHVQSLHH DEHKESKEKADISVTPLSIPIIAGPGTIATVMSLSAGHSGIGHYAAVMIGIAAVIALT FLFFHYSAFISSKLGKTEMNVITRLMGLILAVVAVGMIGAGLKGMFPVLTS*" /label="yvbG CDS" gene complement(2986750..2987385) /gene="yvbG" /locus_tag="BSU_33850" /old_locus_tag="BSU33850" /label="yvbG gene" downshifts complement(2986763) /Source="Nicolas_upshifts" /id="D1758" /incds=0 /nref=21 /ntot=50 /MaxReadThrough="2.02169" /MaxDrop="4.45088" /score="10.9231366" /energy="-16.4" /TU="NA" /idTUdmin="U2669" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2987426..2987444) /Source="Nicolas_upshift_promotors" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2987432) /Source="Nicolas_upshifts" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2987460..2987466) /Source="Nicolas_upshift_promotors" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2987471..2987478 /Source="Nicolas_upshift_promotors" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2987490..2987509 /Source="Nicolas_upshift_promotors" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2987499 /Source="Nicolas_upshifts" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="upshifts" CDS 2987535..2988149 /gene="yvbH" /locus_tag="BSU_33860" /old_locus_tag="BSU33860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391266.1" /db_xref="EnsemblGenomes-Gn:BSU33860" /db_xref="EnsemblGenomes-Tr:CAB15391" /db_xref="InterPro:IPR011993" /db_xref="InterPro:IPR012544" /db_xref="InterPro:IPR021722" /db_xref="InterPro:IPR037063" /db_xref="SubtiList:BG14081" /db_xref="UniProtKB/Swiss-Prot:O32245" /translation="MFKKIAADALGLSDIGKIIEPQDYDKTDADDYVMHEDNEKIYFL IKTKADEYCFTNLALIHVDGERATSSKRTLKRYPYSQYKISDVFLETAGKVDLDVEIK FKLGGEQFDIDVHKDQIEKLKDLYKALLRIAETTYENDILINQAEQSLDKAVTILHHT RPEHVNIETQYKELTEFGFTWLTSVRSQYHIKDFGDVFEKYINN*" /label="yvbH CDS" gene 2987535..2988149 /gene="yvbH" /locus_tag="BSU_33860" /old_locus_tag="BSU33860" /label="yvbH gene" downshifts 2988135 /Source="Nicolas_upshifts" /id="D1759" /incds=0 /nref=110 /ntot=197 /MaxReadThrough="2.66824" /MaxDrop="5.86088" /score="-4.16829989" /energy="-7.9" /TU="U2670" /idTUdmin="U2668" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-35 2988203..2988206 /Source="Nicolas_upshift_promotors" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2988221..2988240 /Source="Nicolas_upshift_promotors" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2988229 /Source="Nicolas_upshifts" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="upshifts" CDS 2988281..2988979 /gene="yvbI" /locus_tag="BSU_33870" /old_locus_tag="BSU33870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391267.1" /db_xref="EnsemblGenomes-Gn:BSU33870" /db_xref="EnsemblGenomes-Tr:CAB15392" /db_xref="GOA:O32246" /db_xref="InterPro:IPR029038" /db_xref="SubtiList:BG14082" /db_xref="UniProtKB/Swiss-Prot:O32246" /translation="MYCPQCGHQTDGGNFCEKCGSPLPGQSGHQHAAQTGAAAKQAAK QFGSFVLSVLKRPYQECKATGGEQLISAIITMVLFSLLTPLMFYILFSDGPGSVSFTA IFLEPTIYFILFLFGLHACIFFALKIAGNQVSFKDSFSRFGAFLIPFTAILILALFFF LLHTDICFTILAVGLIGAFFAIPPAMLSSYQHSYKGKVDFIYSTIVIYLIICVTFQLI IEHYVKEIFRYMLF*" /label="yvbI CDS" gene 2988281..2988979 /gene="yvbI" /locus_tag="BSU_33870" /old_locus_tag="BSU33870" /label="yvbI gene" downshifts 2988952 /Source="Nicolas_upshifts" /id="D1760" /incds=0 /nref=72 /ntot=203 /MaxReadThrough="1.50622" /MaxDrop="4.71846" /score="17.2112529" /energy="-17.2" /TU="U2671" /idTUdmin="U2671" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(2989015..2990832) /gene="yvbJ" /locus_tag="BSU_33880" /old_locus_tag="BSU33880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15155184" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391268.1" /db_xref="EnsemblGenomes-Gn:BSU33880" /db_xref="EnsemblGenomes-Tr:CAB15393" /db_xref="GOA:O32247" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR026870" /db_xref="SubtiList:BG14083" /db_xref="UniProtKB/Swiss-Prot:O32247" /translation="MLFCKNCGSQNNEGAKFCKQCGTPIGGGSKQANQETASTAETRQ APRKPIPKKTIILWSSIAAACVILFAAYKTGAYFTSKDRLVDKFEQAVNDGDQDQIAT LLTPVNDNLKLTKNNVKPFLTYLKDHPDKKDELFASLRDETAQKDIVYAEKDGKSLLV FDHYDLKVAPVYFEVSSNYKNTDLYVNKEEAGSVKKADQAQTLGPYIPGEYTVSAKLK NDVVDLVKKEDIQAIGDSSFRVDLSLEADDVTFSLANDIKSGKGDLLINGKSIHKDPF KSVTYGPLLTDGSMTASVEAEFPWGKTKTAGVPIDDKEMELTLIPDQDTQEQIMNTIV KTTKQYSKALSDGNTAQMTEASANWKAETKDTVDSMKSADSYLKDRYLETDFDLDTFA LSQKNDGTWQVSVTGKELHQSSSYNDYTKSEMTDDSPSYEYLLSYDKKQKKWIFEDAE STFESAGTNIKKIKNDKPETYTSAWAGSKNKGSESSASGDVTDEQVTLFMGSYLQSQA DAVNQNNFSLMEDSLEKGSSLYSDQQHLVSKLNKEGTTEDFNNYEVKSWSQNGSAITI KTYEEFYITKSGGSPKLRTYNWTYTGVVKNGRIYLTSIQ*" /label="yvbJ CDS" gene complement(2989015..2990832) /gene="yvbJ" /locus_tag="BSU_33880" /old_locus_tag="BSU33880" /label="yvbJ gene" downshifts complement(2989034) /Source="Nicolas_upshifts" /id="D1761" /incds=0 /nref=31 /ntot=189 /MaxReadThrough="2.6958" /MaxDrop="3.67366" /score="15.9345511" /energy="-17.2" /TU="NA" /idTUdmin="U2673" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" downshifts complement(2989205) /Source="Nicolas_upshifts" /id="D1762" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="4.6758" /MaxDrop="2.2812" /score="15.9345511" /energy="-17.2" /TU="U2673" /idTUdmin="U2673" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" misc_feature complement(2990874..2990893) /Source="Nicolas_upshift_promotors" /id="U2673" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.546453546453546" /psig="0.995004995004995" /xcortree=2319 /SigmaFactorBS="cctttttagtctgatagacatttaattttttcattcgttccc aatttcattctgTTTTATTATAAAATATGAAAagcagtaaatgttatcaaattagtag a" /listShort="yvbJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" misc_feature 2990878..2990897 /Source="Nicolas_upshift_promotors" /id="U2672" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.679320679320679" /psig="0.994005994005994" /xcortree=3040 /SigmaFactorBS="aaaataacatgactttcctcctattctactaatttgataaca tttactgcttttcATATTTTATAATAAAACAGAatgaaattgggaacgaatgaaaaaa t" /listShort="yvbK" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2990883 /Source="Nicolas_upshifts" /id="U2672" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.679320679320679" /psig="0.994005994005994" /xcortree=3040 /SigmaFactorBS="aaaataacatgactttcctcctattctactaatttgataaca tttactgcttttcATATTTTATAATAAAACAGAatgaaattgggaacgaatgaaaaaa t" /listShort="yvbK" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2990887) /Source="Nicolas_upshifts" /id="U2673" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.546453546453546" /psig="0.995004995004995" /xcortree=2319 /SigmaFactorBS="cctttttagtctgatagacatttaattttttcattcgttccc aatttcattctgTTTTATTATAAAATATGAAAagcagtaaatgttatcaaattagtag a" /listShort="yvbJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2990952..2991419 /gene="yvbK" /locus_tag="BSU_33890" /old_locus_tag="BSU33890" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acyltransferase" /protein_id="NP_391269.1" /db_xref="EnsemblGenomes-Gn:BSU33890" /db_xref="EnsemblGenomes-Tr:CAB15394" /db_xref="GOA:O32248" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1YVK" /db_xref="SubtiList:BG14084" /db_xref="UniProtKB/Swiss-Prot:O32248" /translation="MNMQKLRIELGEETNDELYDLLLLADPSKDIVDEYLERGECYTA WAGDELAGVYVLLKTRPQTVEIVNIAVKESLQKKGFGKQLVLDAIEKAKKLGADTIEI GTGNSSIHQLSLYQKCGFRIQAIDHDFFLRHYDEDIFENGIQCRDMVRLYLDL*" /label="yvbK CDS" gene 2990952..2991419 /gene="yvbK" /locus_tag="BSU_33890" /old_locus_tag="BSU33890" /label="yvbK gene" downshifts 2991416 /Source="Nicolas_upshifts" /id="D1763" /incds=0 /nref=199 /ntot=250 /MaxReadThrough="1.84358" /MaxDrop="5.3321" /score="15.9040274" /energy="-13.3" /TU="U2672" /idTUdmin="U2672" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(2991464..2992756) /gene="eno" /locus_tag="BSU_33900" /old_locus_tag="BSU33900" /EC_number="4.2.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8021172, 9588797, 12682299, 15301535, 19193632, 19215769, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021172, 9588797, 12682299, 15301535, 19193632, 19215769, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enolase" /protein_id="NP_391270.1" /db_xref="EnsemblGenomes-Gn:BSU33900" /db_xref="EnsemblGenomes-Tr:CAB15395" /db_xref="GOA:P37869" /db_xref="InterPro:IPR000941" /db_xref="InterPro:IPR020809" /db_xref="InterPro:IPR020810" /db_xref="InterPro:IPR020811" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="PDB:4A3R" /db_xref="SubtiList:BG10899" /db_xref="UniProtKB/Swiss-Prot:P37869" /translation="MPYIVDVYAREVLDSRGNPTVEVEVYTETGAFGRALVPSGASTG EYEAVELRDGDKDRYLGKGVLTAVNNVNEIIAPELLGFDVTEQNAIDQLLIELDGTEN KGKLGANAILGVSMACARAAADFLQIPLYQYLGGFNSKTLPVPMMNIVNGGEHADNNV DIQEFMIMPVGAPNFREALRMGAQIFHSLKSVLSAKGLNTAVGDEGGFAPNLGSNEEA LQTIVEAIEKAGFKPGEEVKLAMDAASSEFYNKEDGKYHLSGEGVVKTSAEMVDWYEE LVSKYPIISIEDGLDENDWEGHKLLTERLGKKVQLVGDDLFVTNTKKLSEGIKNGVGN SILIKVNQIGTLTETFDAIEMAKRAGYTAVISHRSGETEDSTIADIAVATNAGQIKTG APSRTDRVAKYNQLLRIEDQLAETAQYHGINSFYNLNK*" /label="eno CDS" gene complement(2991464..2992756) /gene="eno" /locus_tag="BSU_33900" /old_locus_tag="BSU33900" /label="eno gene" downshifts complement(2991474) /Source="Nicolas_upshifts" /id="D1764" /incds=0 /nref=254 /ntot=269 /MaxReadThrough="2.21852" /MaxDrop="9.34136" /score="29.8674712" /energy="-15" /TU="NA" /idTUdmin="U2674" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(2992786..2994321) /gene="pgm" /locus_tag="BSU_33910" /old_locus_tag="BSU33910" /EC_number="5.4.2.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9830105, 10869096, 12682299, 19193632, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9830105, 10869096, 12682299, 19193632, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoglycerate mutase" /protein_id="NP_391271.1" /db_xref="EnsemblGenomes-Gn:BSU33910" /db_xref="EnsemblGenomes-Tr:CAB15396" /db_xref="GOA:P39773" /db_xref="InterPro:IPR005995" /db_xref="InterPro:IPR006124" /db_xref="InterPro:IPR011258" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR036646" /db_xref="SubtiList:BG10898" /db_xref="UniProtKB/Swiss-Prot:P39773" /translation="MSKKPAALIILDGFGLRNETVGNAVALAKKPNFDRYWNQYPHQT LTASGEAVGLPEGQMGNSEVGHLNIGAGRIVYQSLTRVNVAIREGEFERNQTFLDAIS NAKENNKALHLFGLLSDGGVHSHINHLFALLKLAKKEGLTKVYIHGFLDGRDVGPQTA KTYINQLNDQIKEIGVGEIASISGRYYSMDRDKRWDRVEKAYRAMAYGEGPSYRSALD VVDDSYANGIYDEFVIPSVITKENGEPVAKIQDGDSVIFYNFRPDRAIQISNTFTNKD FRDFDRGENYPKNLYFVCLTHFSETVDGYVAFKPINLDNTVGEVLSQHGLKQLRIAET EKYPHVTFFMSGGREAEFPGEERILINSPKVATYDLKPEMSAYEVKDALVKEIEADKH DAIILNFANPDMVGHSGMVEPTIKAIEAVDECLGEVVDAILAKGGHAIITADHGNADI LITESGEPHTAHTTNPVPVIVTKEGITLREGGILGDLAPTLLDLLGVEKPKEMTGTSL IQK*" /label="pgm CDS" gene complement(2992786..2994321) /gene="pgm" /locus_tag="BSU_33910" /old_locus_tag="BSU33910" /label="pgm gene" CDS complement(2994314..2995075) /gene="tpiA" /locus_tag="BSU_33920" /old_locus_tag="BSU33920" /EC_number="5.3.1.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8021172, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="triose phosphate isomerase" /protein_id="NP_391272.1" /db_xref="EnsemblGenomes-Gn:BSU33920" /db_xref="EnsemblGenomes-Tr:CAB15397" /db_xref="GOA:P27876" /db_xref="InterPro:IPR000652" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR020861" /db_xref="InterPro:IPR022896" /db_xref="InterPro:IPR035990" /db_xref="SubtiList:BG10897" /db_xref="UniProtKB/Swiss-Prot:P27876" /translation="MRKPIIAGNWKMNKTLGEAVSFVEEVKSSIPAADKAEAVVCAPA LFLEKLASAVKGTDLKVGAQNMHFEESGAFTGEISPVALKDLGVDYCVIGHSERREMF AETDETVNKKAHAAFKHGIVPIICVGETLEEREAGKTNDLVADQVKKGLAGLSEEQVA ASVIAYEPIWAIGTGKSSTAKDANDVCAHIRKTVAESFSQEAADKLRIQYGGSVKPAN IKEYMAESDIDGALVGGASLEPQSFVQLLEEGQYE*" /label="tpiA CDS" gene complement(2994314..2995075) /gene="tpiA" /locus_tag="BSU_33920" /old_locus_tag="BSU33920" /label="tpiA gene" CDS complement(2995106..2996290) /gene="pgk" /locus_tag="BSU_33930" /old_locus_tag="BSU33930" /EC_number="2.7.2.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559176, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559176, 12682299, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoglycerate kinase" /protein_id="NP_391273.1" /db_xref="EnsemblGenomes-Gn:BSU33930" /db_xref="EnsemblGenomes-Tr:CAB15398" /db_xref="GOA:P40924" /db_xref="InterPro:IPR001576" /db_xref="InterPro:IPR015824" /db_xref="InterPro:IPR015911" /db_xref="InterPro:IPR036043" /db_xref="SubtiList:BG11062" /db_xref="UniProtKB/Swiss-Prot:P40924" /translation="MNKKTLKDIDVKGKVVFCRVDFNVPMKDGEVTDDTRIRAALPTI KHLADQGAKVLLASHLGRPKGEVVEELRLTPVAARLGELLGKEVKKADEAYGDAVKAQ ISEMKDGDVLVLENVRFYPGEEKNDPELAKAFAELADVYVNDAFGAAHRAHASTAGIA EHLPAVAGFLMEKELDVLGKAVSNPDRPFTAIIGGAKVKDKIGVIESLLDKVDNLIIG GGLAYTFVKALGYEVGKSLLEEDKIELAKSFMDRAKEKGVNFYMPEDVLVADDFSNDA NVKIVPISEIPSDLEAIDIGTKTRETYADVIKNSKLVVWNGPMGVFEIDLFAQGTKAV AEALAEAKDTYSVIGGGDSAAAVEKFGLADKMSHISTGGGASLEFMEGKELPGVAALN DK*" /label="pgk CDS" gene complement(2995106..2996290) /gene="pgk" /locus_tag="BSU_33930" /old_locus_tag="BSU33930" /label="pgk gene" S_feature complement(2996291..2996531) /Source="Nicolas_S_feature" /locus_tag="new_3481382_3481622_c" /HighExp="Lbstat, Lbtran, C90, LBGtran, LBGexp, G150, M40t45, LPhT, M0t45, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA, SigK" /TUshortPSig="0.979, 0.136, 0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1300" upshifts complement(2996531) /Source="Nicolas_upshifts" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2996533..2996606) /Source="Nicolas_S_feature" /locus_tag="new_3481624_3481697_c" /HighExp="C90, LBGtran, Lbstat, LBGexp, Lbtran, G150, M40t45, Etha, ferm, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigK" /TUshortPSig="0.136, 0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1301" promotor_-10 complement(2996545..2996564) /Source="Nicolas_upshift_promotors" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2996580..2996584) /Source="Nicolas_upshift_promotors" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2996607..2997614) /gene="gapA" /locus_tag="BSU_33940" /old_locus_tag="BSU33940" /EC_number="1.2.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9588797, 10799476, 12123463, 12634343, 17142398, 27449348, 28760849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9588797, 10799476, 12123463, 12634343, 17142398, 27449348, 28760849; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyceraldehyde-3-phosphate dehydrogenase (NAD-dependent, glycolytic)" /protein_id="NP_391274.1" /db_xref="EnsemblGenomes-Gn:BSU33940" /db_xref="EnsemblGenomes-Tr:CAB15399" /db_xref="GOA:P09124" /db_xref="InterPro:IPR006424" /db_xref="InterPro:IPR020828" /db_xref="InterPro:IPR020829" /db_xref="InterPro:IPR020830" /db_xref="InterPro:IPR020831" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10827" /db_xref="UniProtKB/Swiss-Prot:P09124" /translation="MAVKVGINGFGRIGRNVFRAALNNPEVEVVAVNDLTDANMLAHL LQYDSVHGKLDAEVSVDGNNLVVNGKTIEVSAERDPAKLSWGKQGVEIVVESTGFFTK RADAAKHLEAGAKKVIISAPANEEDITIVMGVNEDKYDAANHDVISNASCTTNCLAPF AKVLNDKFGIKRGMMTTVHSYTNDQQILDLPHKDYRRARAAAENIIPTSTGAAKAVSL VLPELKGKLNGGAMRVPTPNVSLVDLVAELNQEVTAEEVNAALKEAAEGDLKGILGYS EEPLVSGDYNGNKNSSTIDALSTMVMEGSMVKVISWYDNESGYSNRVVDLAAYIAKKG L*" /label="gapA CDS" gene complement(2996607..2997614) /gene="gapA" /locus_tag="BSU_33940" /old_locus_tag="BSU33940" /label="gapA gene" promotor_-35 2997533..2997536 /Source="Nicolas_upshift_promotors" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2997553..2997555 /Source="Nicolas_upshift_promotors" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2997555 /Source="Nicolas_upshifts" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2997661..2998683) /gene="cggR" /locus_tag="BSU_33950" /old_locus_tag="BSU33950" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11489127, 12622823, 17142398, 17293407, 18052209, 18554327" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489127, 12622823, 17142398, 17293407, 18052209, 18554327; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of gapA" /protein_id="NP_391275.1" /db_xref="EnsemblGenomes-Gn:BSU33950" /db_xref="EnsemblGenomes-Tr:CAB15400" /db_xref="GOA:O32253" /db_xref="InterPro:IPR007324" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2OKG" /db_xref="PDB:3BXE" /db_xref="PDB:3BXF" /db_xref="PDB:3BXG" /db_xref="PDB:3BXH" /db_xref="SubtiList:BG14085" /db_xref="UniProtKB/Swiss-Prot:O32253" /translation="MNQLIQAQKKLLPDLLLVMQKRFEILQYIRLTEPIGRRSLSASL GISERVLRGEVQFLKEQNLVDIKTNGMTLTEEGYELLSVLEDTMKDVLGLTLLEKTLK ERLNLKDAIIVSGDSDQSPWVKKEMGRAAVACMKKRFSGKNIVAVTGGTTIEAVAEMM TPDSKNRELLFVPARGGLGEDVKNQANTICAHMAEKASGTYRLLFVPGQLSQGAYSSI IEEPSVKEVLNTIKSASMLVHGIGEAKTMAQRRNTPLEDLKKIDDNDAVTEAFGYYFN ADGEVVHKVHSVGMQLDDIDAIPDIIAVAGGSSKAEAIEAYFKKPRNTVLVTDEGAAK KLLRDE*" /label="cggR CDS" gene complement(2997661..2998683) /gene="cggR" /locus_tag="BSU_33950" /old_locus_tag="BSU33950" /label="cggR gene" upshifts complement(2997677) /Source="Nicolas_upshifts" /id="U2676" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.313686313686314" /psig="0.135864135864136" /xcortree=2684 /SigmaFactorBS="cttactttaaaaagccacgcaacacggttctCGtcacagacg aaggagccgcAaagaagttattaagggatgaataatccctcaatataaatatctctca c" /listShort="gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2997705..2997706) /Source="Nicolas_upshift_promotors" /id="U2676" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.313686313686314" /psig="0.135864135864136" /xcortree=2684 /SigmaFactorBS="cttactttaaaaagccacgcaacacggttctCGtcacagacg aaggagccgcAaagaagttattaagggatgaataatccctcaatataaatatctctca c" /listShort="gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2998684..2998795) /Source="Nicolas_S_feature" /locus_tag="new_3483775_3483886_c" /HighExp="LPhT, C90, LBGtran, Heat, BI, LBGexp, Lbstat, Sw, Lbexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1302" downshifts 2998721 /Source="Nicolas_upshifts" /id="D1765" /incds=0 /nref=3 /ntot=50 /MaxReadThrough="4.48989" /MaxDrop="5.24842" /score="-9.71393179" /energy="-11.8" /TU="NA" /idTUdmin="U2675" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2998776..2998795) /Source="Nicolas_upshift_promotors" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2998795) /Source="Nicolas_upshifts" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2998797..2998907) /Source="Nicolas_S_feature" /locus_tag="new_3483888_3483998_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, S3, B60, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1303" promotor_-35 complement(2998809..2998816) /Source="Nicolas_upshift_promotors" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2998890..2998909) /Source="Nicolas_upshift_promotors" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="promotor_-10" upshifts complement(2998905) /Source="Nicolas_upshifts" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="upshifts" promotor_-35 complement(2998922..2998931) /Source="Nicolas_upshift_promotors" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="promotor_-35" CDS complement(2998981..3000375) /gene="araE" /locus_tag="BSU_33960" /old_locus_tag="BSU33960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9620981, 10417639, 15849754, 16850406, 20693325" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9620981, 10417639, 15849754, 16850406, 20693325; Product type t : transporter" /codon_start=1 /transl_table=11 /product="arabinose-related compounds permease" /protein_id="NP_391276.1" /db_xref="EnsemblGenomes-Gn:BSU33960" /db_xref="EnsemblGenomes-Tr:CAB15401" /db_xref="GOA:P96710" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11907" /db_xref="UniProtKB/Swiss-Prot:P96710" /translation="MKNTPTQLEPNVPVTRSHSMGFVILISCAAGLGGLLYGYDTAVI SGAIGFLKDLYSLSPFMEGLVISSIMIGGVVGVGISGFLSDRFGRRKILMTAALLFAI SAIVSALSQDVSTLIIARIIGGLGIGMGSSLSVTYITEAAPPAIRGSLSSLYQLFTIL GISATYFINLAVQRSGTYEWGVHTGWRWMLAYGMVPSVIFFLVLLVVPESPRWLAKAG KTNEALKILTRINGETVAKEELKNIENSLKIEQMGSLSQLFKPGLRKALVIGILLALF NQVIGMNAITYYGPEIFKMMGFGQNAGFVTTCIVGVVEVIFTVIAVLLIDKVGRKKLM SIGSAFMAIFMILIGTSFYFELTSGIMMIVLILGFVAAFCVSVGPITWIMISEIFPNH LRARAAGIATIFLWGANWAIGQFVPMMIDSFGLAYTFWIFAVINILCFLFVVTICPET KNKSLEEIEKLWIK*" /label="araE CDS" gene complement(2998981..3000375) /gene="araE" /locus_tag="BSU_33960" /old_locus_tag="BSU33960" /label="araE gene" downshifts complement(2998995) /Source="Nicolas_upshifts" /id="D1766" /incds=0 /nref=1 /ntot=23 /MaxReadThrough="1.15614" /MaxDrop="3.28809" /score="1.06999853" /energy="-14.6" /TU="NA" /idTUdmin="U2679" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3000474..3000493) /Source="Nicolas_upshift_promotors" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3000488) /Source="Nicolas_upshifts" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3000508..3000515) /Source="Nicolas_upshift_promotors" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3000515..3000522 /Source="Nicolas_upshift_promotors" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3000536..3000555 /Source="Nicolas_upshift_promotors" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3000542 /Source="Nicolas_upshifts" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="upshifts" CDS 3000579..3001667 /gene="araR" /locus_tag="BSU_33970" /old_locus_tag="BSU33970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 12949161, 14973026, 16585763, 17617643, 22281747, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 12949161, 14973026, 16585763, 17617643, 22281747, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the ara regulon (LacI family)" /protein_id="NP_391277.2" /db_xref="EnsemblGenomes-Gn:BSU33970" /db_xref="EnsemblGenomes-Tr:CAB15402" /db_xref="GOA:P96711" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR028082" /db_xref="InterPro:IPR033532" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3TB6" /db_xref="PDB:4EGY" /db_xref="PDB:4EGZ" /db_xref="PDB:4H0E" /db_xref="PDB:5D4R" /db_xref="PDB:5D4S" /db_xref="SubtiList:BG11913" /db_xref="UniProtKB/Swiss-Prot:P96711" /translation="MLPKYAQVKEEISSWINQGKILPDQKIPTENELMQQFGVSRHTI RKAIGDLVSQGLLYSVQGGGTFVASRSAKSALHSNKTIGVLTTYISDYIFPSIIRGIE SYLSEQGYSMLLTSTNNNPDNERRGLENLLSQHIDGLIVEPTKSALQTPNIGYYLNLE KNGIPFAMINASYAELAAPSFTLDDVKGGMMAAEHLLSLGHTHMMGIFKADDTQGVKR MNGFIQAHRERELFPSPDMIVTFTTEEKESKLLEKVKATLEKNSKHMPTAILCYNDEI ALKVIDMLREMDLKVPEDMSIVGYDDSHFAQISEVKLTSVKHPKSVLGKAAAKYVIDC LEHKKPKQEDVIFEPELIIRQSARKLNE*" /label="araR CDS" gene 3000579..3001667 /gene="araR" /locus_tag="BSU_33970" /old_locus_tag="BSU33970" /label="araR gene" downshifts 3001647 /Source="Nicolas_upshifts" /id="D1767" /incds=0 /nref=202 /ntot=247 /MaxReadThrough="1.17419" /MaxDrop="4.76041" /score="20.2322165" /energy="-13.6" /TU="NA" /idTUdmin="U2680" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3001716..3002726) /gene="yvbT" /locus_tag="BSU_33980" /old_locus_tag="BSU33980" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9836433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alkanal monooxygenase" /protein_id="NP_391278.1" /db_xref="EnsemblGenomes-Gn:BSU33980" /db_xref="EnsemblGenomes-Tr:CAB15403" /db_xref="GOA:O32254" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG14086" /db_xref="UniProtKB/Swiss-Prot:O32254" /translation="MSNNQRKDTLLSVLNLSPVVQGGTIAESFRNSMDLARRAEEWGY HRYWLAEHHNIEGVASSATAVLIGHIAGGTKKIRVGSGGIMLPNHSSLVIAEQFGTLE TLYPGRIDLGLGRAPGTDQLTARALRRNINSGEDFPEQLEELRNYFKPSGNVRNQVRA IPGEGIDVPIWLLGSSGFSARLAGELGLPFAFAAHFSPANTVPALELYRNSFTPSDVL DEPYAMVGVTIIAADTNEKAQHLATSHYQRFLDLVRGTPNQLKPPVEDMDQIWSPYEK AMVNEQLSSTIVGGPEEVKAKLEDFVKTTQADEIMVNSETFEHADRMRSFEIIADVWK NR*" /label="yvbT CDS" gene complement(3001716..3002726) /gene="yvbT" /locus_tag="BSU_33980" /old_locus_tag="BSU33980" /label="yvbT gene" downshifts complement(3001723) /Source="Nicolas_upshifts" /id="D1768" /incds=0 /nref=200 /ntot=252 /MaxReadThrough="1.53983" /MaxDrop="7.63266" /score="27.2032847" /energy="-14.2" /TU="NA" /idTUdmin="U2681" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3002727..3002804) /Source="Nicolas_S_feature" /locus_tag="new_3487818_3487895_c" /HighExp="dia5, dia15, Diami, H2O2, Salt, Paraq, G180, Etha, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1304" promotor_-10 complement(3002794..3002813) /Source="Nicolas_upshift_promotors" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3002804) /Source="Nicolas_upshifts" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3002827..3002834) /Source="Nicolas_upshift_promotors" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3002883..3003761) /gene="yvbU" /locus_tag="BSU_33990" /old_locus_tag="BSU33990" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391279.1" /db_xref="EnsemblGenomes-Gn:BSU33990" /db_xref="EnsemblGenomes-Tr:CAB15404" /db_xref="GOA:O32255" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14087" /db_xref="UniProtKB/Swiss-Prot:O32255" /translation="MTITQLKVFVKIAETGSFTKAGQALNMTQPAVSHAISAIEAELD VKLIIRDRRNGLMLTDTGKQILVHIREVLKGIEKVEQVAAAEKGLELGTIHIGTFSTA SAYFMPKLISEFKQKYPKLELVLHEGTVNEVKEWLHTRMIDVGILLYPTEEMEYIHLK KDKMAVVLRDDHPLASHSAITLKDLDHEPMIVCDGGYESPFIDMFRQAGATLHPAFTV YNINTSISMIREGLGLAILSEMSMSGMPLPEHVVTRELDPQVYRDVQLAVPSLKEASL AAKLFIEMAKELFGAE*" /label="yvbU CDS" gene complement(3002883..3003761) /gene="yvbU" /locus_tag="BSU_33990" /old_locus_tag="BSU33990" /label="yvbU gene" promotor_-35 3003419..3003425 /Source="Nicolas_upshift_promotors" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3003440..3003451 /Source="Nicolas_upshift_promotors" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3003451 /Source="Nicolas_upshifts" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3003795..3003802 /Source="Nicolas_upshift_promotors" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3003808..3003827) /Source="Nicolas_upshift_promotors" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="promotor_-10" upshifts complement(3003813) /Source="Nicolas_upshifts" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="upshifts" promotor_-10 3003816..3003835 /Source="Nicolas_upshift_promotors" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3003818 /Source="Nicolas_upshifts" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3003841..3003845) /Source="Nicolas_upshift_promotors" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="promotor_-35" CDS 3003861..3004778 /gene="cyeB" /locus_tag="BSU_34000" /old_locus_tag="BSU34000" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10844694, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cysteine and O-acetylserine efflux permease" /protein_id="NP_391280.1" /db_xref="EnsemblGenomes-Gn:BSU34000" /db_xref="EnsemblGenomes-Tr:CAB15405" /db_xref="GOA:O32256" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG14088" /db_xref="UniProtKB/Swiss-Prot:O32256" /translation="MKQLPKTRTALLLAFLVIMWGVNWPLSKAALAYSPPLLFAGIRT LIGGLLLVIVALPRIHKLRLKETWPIYLVSALLNITLFYGLQTIGLNYLPAGLFSAIV FFQPVLMGVFSWLWLGESMFVMKVIGLILGFAGVAVISAAGFGGHISVIGVLLALGSA VSWALGTVYMKKTGSRVDSIWMVALQLTIGSVFLLISGFWTESFSAIQWTAPFITSLL FISVFVIALGWLVFFTLVGSGEASKVASYTFLIPLISIVASSIFLHEPLTLSLLAGLL LIVTSICLVNTKSKAQKAAAIGINEKAAQ*" /label="cyeB CDS" gene 3003861..3004778 /gene="cyeB" /locus_tag="BSU_34000" /old_locus_tag="BSU34000" /label="cyeB gene" downshifts 3004767 /Source="Nicolas_upshifts" /id="D1769" /incds=0 /nref=6 /ntot=15 /MaxReadThrough="2.97475" /MaxDrop="3.548" /score="22.9557936" /energy="-19.2" /TU="NA" /idTUdmin="U2684" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(3004819..3006162) /gene="yvbW" /locus_tag="BSU_34010" /old_locus_tag="BSU34010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19258532, 25645558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative leucine permease" /protein_id="NP_391281.1" /db_xref="EnsemblGenomes-Gn:BSU34010" /db_xref="EnsemblGenomes-Tr:CAB15406" /db_xref="GOA:O32257" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG14089" /db_xref="UniProtKB/Swiss-Prot:O32257" /translation="MKNDNQTLKRTMTSRHIMMMALGGAIGAGLFKGSSSAIDVAGPS VIIAYLLGGIILLFIMQGLAEMAVRNRNARTFRDLVQQVLGNYAAYFLDWIYWKMWVL NIAAEAVVAAIFIQYWLPGCPIWVLALGISLIVTIVNLLSVKIFAETEYWLAMIKITV IIIFIILGLLLLFVSFGDHTASGFSNLTDHGGFFPHGGTGLITAMLVVIYSYGGTEII GVTLAETKNPEKVVPKAVRSTLTRIVAFYLLPFFIIVSLIPWNQVNSVPESPFVMVFK MVGIPGADHIMNAVILLAIISSMNSGLYGSSRILYTQASDGRLPKVFSKLSSKNVPMF AILMCTSSLYIGVLISLFAGSQTFNYLMGSLGYTVLFIWLIIGFAHLKSRKQQTETPA YYVKWFPYTTWFAIVALLAILIGVIMTTSIVITGITAAIYLLITVAYLVKGRKHQ*" /label="yvbW CDS" gene complement(3004819..3006162) /gene="yvbW" /locus_tag="BSU_34010" /old_locus_tag="BSU34010" /label="yvbW gene" misc_RNA complement(3006231..3006466) /gene="tboX" /locus_tag="BSU_misc_RNA_56" /product="T-box riboswitch controlling synthesis of an amino acid transporter" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 18625071, 19258532; Product type n: RNA" /function="16.3: Control" /label="tboX RNA" gene complement(3006231..3006466) /gene="tboX" /locus_tag="BSU_misc_RNA_56" /label="tboX gene" downshifts complement(3006365) /Source="Nicolas_upshifts" /id="D1770" /incds=1 /nref=1 /ntot=104 /MaxReadThrough="5.18182" /MaxDrop="2.29735" /score="33.4262209" /energy="-24.4" /TU="U2685,U2689" /idTUdmin="U2689" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(3006467..3006563) /Source="Nicolas_S_feature" /locus_tag="new_3491558_3491654_c" /HighExp="Cold, GM 120, C30, GM 90, C90, GM 15, GM 10, GM 25, HPh, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 0.994" /TUlongSig="SigA" /TUlongPSig=1 /label="S1305" CDS complement(3006564..3007598) /gene="yvbX" /locus_tag="BSU_34020" /old_locus_tag="BSU34020" /function="16.5: Explore" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12177332; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative epimerase modification of peptidoglycan" /protein_id="NP_391282.1" /db_xref="EnsemblGenomes-Gn:BSU34020" /db_xref="EnsemblGenomes-Tr:CAB15407" /db_xref="GOA:O32258" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG14090" /db_xref="UniProtKB/Swiss-Prot:O32258" /translation="MKKWLIIAVSLAIAIVLFMYTKGEAKAAGMTVGYTTGDTASYNS LTKYHTYMNAIATDTFAFEKNGQIIGDAPTKQLTYAKKKKIKTWAVISNYNDAIYDFD GDLASRVMSNKTAKKRFTDQLITLAKKHSYYGINIDFEAVNPEDRAAYSNFIQYVSQA LNKKHIKTMVSVPAKSADDKNDDWSWPYDYAKIGKYADFVQVMTYDEHGIWGEPGSVA STNWIKSSLQFSVKKIKANKVIMGIPAYGYDWDVKDGSTSTIREWNELKSLIKKQKAK PAFNKKSGSMTFSYVDKKKHKHVVWYENEKTVQTKSHLAKQYKIAGVSVYALGNESES FWKAIRKGTK*" /label="yvbX CDS" gene complement(3006564..3007598) /gene="yvbX" /locus_tag="BSU_34020" /old_locus_tag="BSU34020" /label="yvbX gene" promotor_-10 complement(3007620..3007638) /Source="Nicolas_upshift_promotors" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3007626) /Source="Nicolas_upshifts" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3007651..3007658) /Source="Nicolas_upshift_promotors" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3007706..3008428) /gene="lutC" /locus_tag="BSU_34030" /old_locus_tag="BSU34030" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:22427629, 24196425, 24274019" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22427629, 24196425, 24274019; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="component of an iron-sulfur oxidase for L-lactate utilization" /protein_id="NP_391283.1" /db_xref="EnsemblGenomes-Gn:BSU34030" /db_xref="EnsemblGenomes-Tr:CAB15408" /db_xref="InterPro:IPR003741" /db_xref="InterPro:IPR022823" /db_xref="SubtiList:BG14091" /db_xref="UniProtKB/Swiss-Prot:O32259" /translation="MTKGTIQNQESFLNRIASSLGRERRTGGVAVPEWAHQPQYKTLE GYSADDLVTVLKNHCVKIHTELIETDSTGLYDALREQVSRFSGGPVIIPKDPRFEEYG LKSLLTKDWPSEGTPVWEWDADKGEENIKKAEQANVGITFSEITLAESGTVVLFSSKD IGRSVSLLPTTYIAIVPKSSIVPRMTQASDIIRQNIANGVTVPSCINYITGPSNSADI EMDLVVGVHGPVKAAYILVSDR*" /label="lutC CDS" gene complement(3007706..3008428) /gene="lutC" /locus_tag="BSU_34030" /old_locus_tag="BSU34030" /label="lutC gene" downshifts complement(3007722) /Source="Nicolas_upshifts" /id="D1771" /incds=0 /nref=194 /ntot=266 /MaxReadThrough="4.5919" /MaxDrop="7.41457" /score="25.5917046" /energy="-15.7" /TU="U2689" /idTUdmin="U2689" /TUdmin="-1423" /isTUend="FALSE" /label="downshifts" CDS complement(3008428..3009867) /gene="lutB" /locus_tag="BSU_34040" /old_locus_tag="BSU34040" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="component of an iron-sulfur oxidase linked to L-lactate utilization" /protein_id="NP_391284.1" /db_xref="EnsemblGenomes-Gn:BSU34040" /db_xref="EnsemblGenomes-Tr:CAB15409" /db_xref="GOA:O07021" /db_xref="InterPro:IPR003741" /db_xref="InterPro:IPR004452" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR022825" /db_xref="InterPro:IPR024569" /db_xref="SubtiList:BG12448" /db_xref="UniProtKB/Swiss-Prot:O07021" /translation="MAMKIGTDAFKERVSQGIDNEFMRGAVSGAQERLRTRRLEAAEE LGNWEEWRSLSEEIRQHVLENLDFYLGQLAENVAKRGGHVYFAKTAEEASSYIRDVIQ KKNGKKIVKSKSMVTEEINLNEVLEKEGCEVVETDLGEYILQIDDHDPPSHIVAPALH KNKEQIRDVFKERLDYQHTEKPEELVMHARAILRKKFLEADIGITGCNFAIADTGSVS LVTNEGNGRLVSTLPKTQITVMGMERIVPSFSEFEVLVSMLTRSAVGQRLTSYITALT GPKLEGEVDGPEEFHLVIVDNGRSNILGTEFQSVLQCIRCAACINVCPVYRHVGGHSY GSIYSGPIGAVLSPLLGGYDDYKELPYASSLCAACSEACPVKIPLHELLLKHRQNIVE KEGRAPISEKLAMKAFGLGASSLSLYKMGSKWAPAAMTPFTEDEKISKGPGPLKNWTQ IRDFPAPHKSRFRDWFADRETSERTKEEQ*" /label="lutB CDS" gene complement(3008428..3009867) /gene="lutB" /locus_tag="BSU_34040" /old_locus_tag="BSU34040" /label="lutB gene" promotor_-35 3009415..3009418 /Source="Nicolas_upshift_promotors" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3009435 /Source="Nicolas_upshifts" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3009436..3009440 /Source="Nicolas_upshift_promotors" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 3009589 /Source="Nicolas_upshifts" /id="D1772" /incds=1 /nref=1 /ntot=175 /MaxReadThrough="1.77859" /MaxDrop="3.31917" /score="-7.50175872" /energy="-11.7" /TU="NA" /idTUdmin="U2686" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts 3009743 /Source="Nicolas_upshifts" /id="U2687" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.932067932067932" /psig="0.000999000999001" /xcortree=69 /SigmaFactorBS="acatgctgcctgatttcctctgataatgagcgccactcctcc cagtttcccagttcttctgCTgcctctaggcgccgcgtccgcagacgctcctgtgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3009744..3009745 /Source="Nicolas_upshift_promotors" /id="U2687" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.932067932067932" /psig="0.000999000999001" /xcortree=69 /SigmaFactorBS="acatgctgcctgatttcctctgataatgagcgccactcctcc cagtttcccagttcttctgCTgcctctaggcgccgcgtccgcagacgctcctgtgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3009894..3010610) /gene="lutA" /locus_tag="BSU_34050" /old_locus_tag="BSU34050" /EC_number="1.8.98.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-sulfur oxidase subunit used in L-lactate utilization" /protein_id="NP_391285.1" /db_xref="EnsemblGenomes-Gn:BSU34050" /db_xref="EnsemblGenomes-Tr:CAB15410" /db_xref="GOA:O07020" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR022822" /db_xref="SubtiList:BG12447" /db_xref="UniProtKB/Swiss-Prot:O07020" /translation="MKVSLFVTCLVDMFQTNVGKATVELLERLGCEVDFPEGQICCGQ PAYNSGYVHDAKKAMKRMIETFQDSEYVVSPSGSCTTMFREYPHLFQDDPKWADKAKK LADKTYELTDFIVNVLGVEDVGATLHTKATLHTSCHMTRLLGVRKEPMKLLSHVKGLQ FTELPGKHNCCGFGGTFSVKMAQISEQMVDEKVECVEETGAEVLIGADCGCLMNIGGR LGRKDKNVKVMHIAEVLNSR*" /label="lutA CDS" gene complement(3009894..3010610) /gene="lutA" /locus_tag="BSU_34050" /old_locus_tag="BSU34050" /label="lutA gene" promotor_-35 3010514..3010521 /Source="Nicolas_upshift_promotors" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3010535..3010537 /Source="Nicolas_upshift_promotors" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3010535 /Source="Nicolas_upshifts" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3010608 /Source="Nicolas_upshifts" /id="D1773" /incds=0 /nref=15 /ntot=169 /MaxReadThrough="1.96527" /MaxDrop="4.662" /score="-7.50175872" /energy="-11.7" /TU="NA" /idTUdmin="U2688" /TUdmin="-15" /isTUend="TRUE" /label="downshifts" S_feature complement(3010611..3010677) /Source="Nicolas_S_feature" /locus_tag="new_3495702_3495768_c" /HighExp="C90, M40t90, T3.0H, T4.0H, HiOs, T1.0H, T3.30H, T2.30H, Lbstat, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="SigA" /TUlongPSig=1 /label="S1306" promotor_-10 complement(3010674..3010693) /Source="Nicolas_upshift_promotors" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="promotor_-10" upshifts complement(3010677) /Source="Nicolas_upshifts" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="upshifts" promotor_-35 complement(3010708..3010715) /Source="Nicolas_upshift_promotors" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="promotor_-35" CDS complement(3010785..3011387) /gene="yvfU" /locus_tag="BSU_34060" /old_locus_tag="BSU34060" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 18925929, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18925929, 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YvfT]" /protein_id="NP_391286.1" /db_xref="EnsemblGenomes-Gn:BSU34060" /db_xref="EnsemblGenomes-Tr:CAB15411" /db_xref="GOA:O07019" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12446" /db_xref="UniProtKB/Swiss-Prot:O07019" /translation="MIRLFIAEDQRMLLGALGSLLDLEEDMTVIGQALNGEEALHAIL KLEPDVCIMDIEMPVRSGLNVAEELMKKGCVSKVIILTTFARPGYFERAVKAGAHGYL LKDGEIDDLADAIRKCVKGKRVFSPELTFNMMRDENPLTVREQEILRLAALGKTTKDI TLELYLSQGTVRNYISEIIQKLNAKNRTEAASIAEEKGWI*" /label="yvfU CDS" gene complement(3010785..3011387) /gene="yvfU" /locus_tag="BSU_34060" /old_locus_tag="BSU34060" /label="yvfU gene" CDS complement(3011404..3012519) /gene="yvfT" /locus_tag="BSU_34070" /old_locus_tag="BSU34070" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 18925929, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18925929, 23504016; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YvfU]" /protein_id="NP_391287.2" /db_xref="EnsemblGenomes-Gn:BSU34070" /db_xref="EnsemblGenomes-Tr:CAB15412" /db_xref="GOA:Q795K2" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12445" /db_xref="UniProtKB/Swiss-Prot:Q795K2" /translation="MKKAISIFPKEFGFFPYIFLVYTIMPFLSLLKESGVKQGIGYGM LLLFVAAYRQLFCSVGKASFTYWLIVQMAVILMYSVFYNITYIYLGFFPANFVGYYKE KTNFNRAFCALIFILLFPCLYQFIANSVSLRELFSVLPFLVIMLISPFGIRSMFRRIE LEAKLAQANEQIKELSKREERVRIARDLHDTLGHTLSLLTLKSQLIQRLAASDPERTK LEAKEMETSSRSALKQVRELVSDMRTVTITEELVNIQHILRAGNITFQYEGADDFSVI SPVTQNIISMCMREAVTNIIKHSKATHCAITISQFADKMRIVIRDDGKGAPKEKMFGN GLWGMEERLMLIEGGLTVSDHNGTVVALTIPLIKKAE*" /label="yvfT CDS" gene complement(3011404..3012519) /gene="yvfT" /locus_tag="BSU_34070" /old_locus_tag="BSU34070" /label="yvfT gene" CDS complement(3012523..3013260) /gene="yvfS" /locus_tag="BSU_34080" /old_locus_tag="BSU34080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_391288.1" /db_xref="EnsemblGenomes-Gn:BSU34080" /db_xref="EnsemblGenomes-Tr:CAB15413" /db_xref="GOA:O07017" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12444" /db_xref="UniProtKB/Swiss-Prot:O07017" /translation="MNVLQKQSIAEMKRVLRNKYFVLWSLIMPIAFYYFFTNVVNTNV PDQRAWEAHYLMSMTVFSVMGSSIMTLGIRMVQERSQGWAAFIRLTPLPDHIYLSAQM IGQSVIHVLSITVIFLFGAIINDIALSPFEWMMSGLWILFGALPFLALGTLIGLMRKV ETAAGISNVLYMLLALGGGMWMPFEVMPDMMQSIGQWLPSYHFGSGAWELVRGGSPTW KNILILIAYMMLFMLLSKYIRRKQEAV*" /label="yvfS CDS" gene complement(3012523..3013260) /gene="yvfS" /locus_tag="BSU_34080" /old_locus_tag="BSU34080" /label="yvfS gene" promotor_-10 complement(3012549..3012568) /Source="Nicolas_upshift_promotors" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="promotor_-10" upshifts complement(3012563) /Source="Nicolas_upshifts" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="upshifts" promotor_-35 complement(3012580..3012587) /Source="Nicolas_upshift_promotors" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="promotor_-35" CDS complement(3013261..3014166) /gene="yvfR" /locus_tag="BSU_34090" /old_locus_tag="BSU34090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC efflux transporter (ATP-binding protein)" /protein_id="NP_391289.1" /db_xref="EnsemblGenomes-Gn:BSU34090" /db_xref="EnsemblGenomes-Tr:CAB15414" /db_xref="GOA:O07016" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12443" /db_xref="UniProtKB/Swiss-Prot:O07016" /translation="MMKEAVTVSNVTKHFQRKTAVNNISFSIEKGEIAAILGPNGAGK TTVVSMILGLLKPSEGEIKLFNRVPDDQQVREKIGVMLQEVSVMPGLKVDEILELFRS YYPNPLSMKELVSLTALTKEDLKTRAEKLSGGQKRRLSFALALAGNPELLILDEPTVG MDTSSRHRFWQTIHGLSDQGKTIIFSTHYLQEADDAAQRILFFTEGQLVADGSPMQIR SRIQKQSVSFTLHSSESLERLSCHPEVERVIHEHERTIIQTSNTDKVLALIFQENIHA RDIRIEQATLDEAFRQLADGNREAM*" /label="yvfR CDS" gene complement(3013261..3014166) /gene="yvfR" /locus_tag="BSU_34090" /old_locus_tag="BSU34090" /label="yvfR gene" promotor_-10 complement(3014186..3014204) /Source="Nicolas_upshift_promotors" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3014197) /Source="Nicolas_upshifts" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3014220..3014223) /Source="Nicolas_upshift_promotors" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3014375..3014382 /Source="Nicolas_upshift_promotors" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3014393..3014412 /Source="Nicolas_upshift_promotors" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3014400 /Source="Nicolas_upshifts" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="upshifts" CDS 3014450..3015259 /gene="rsbQ" /locus_tag="BSU_34100" /old_locus_tag="BSU34100" /function="16.3: Control" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11591687, 12620626, 15632289, 21980452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591687, 12620626, 15632289, 21980452; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of RsbP phosphatase" /protein_id="NP_391290.1" /db_xref="EnsemblGenomes-Gn:BSU34100" /db_xref="EnsemblGenomes-Tr:CAB15415" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR031143" /db_xref="PDB:1WOM" /db_xref="PDB:1WPR" /db_xref="SubtiList:BG12442" /db_xref="UniProtKB/Swiss-Prot:O07015" /translation="MNEAILSRNHVKVKGSGKASIMFAPGFGCDQSVWNAVAPAFEED HRVILFDYVGSGHSDLRAYDLNRYQTLDGYAQDVLDVCEALDLKETVFVGHSVGALIG MLASIRRPELFSHLVMVGPSPCYLNDPPEYYGGFEEEQLLGLLEMMEKNYIGWATVFA ATVLNQPDRPEIKEELESRFCSTDPVIARQFAKAAFFSDHREDLSKVTVPSLILQCAD DIIAPATVGKYMHQHLPYSSLKQMEARGHCPHMSHPDETIQLIGDYLKAHV*" /label="rsbQ CDS" gene 3014450..3015259 /gene="rsbQ" /locus_tag="BSU_34100" /old_locus_tag="BSU34100" /label="rsbQ gene" CDS 3015295..3016506 /gene="rsbP" /locus_tag="BSU_34110" /old_locus_tag="BSU34110" /EC_number="3.1.3.3" /function="16.8: Protect" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10632888, 11591687, 15342585, 15632289, 16267279, 19948797, 21980452, 23524614" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10632888, 11591687, 15342585, 15632289, 16267279, 19948797, 21980452, 23524614; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoserine protein-phosphatase" /protein_id="NP_391291.1" /db_xref="EnsemblGenomes-Gn:BSU34110" /db_xref="EnsemblGenomes-Tr:CAB15416" /db_xref="GOA:O07014" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036457" /db_xref="SubtiList:BG12441" /db_xref="UniProtKB/Swiss-Prot:O07014" /translation="MDKQLNDAPCGFLALSEEGSIIAANRTLIKILDYEPEQVIGQHM NMMLTIPAQLFCQLYFFPLLKLEHHIEEIYISLKARDGEEIPVLINAIARHDSGASVF DCVLIPMRKRNEYENELLIARNEAQEALLAKQKANAELEIALETLKAKQEELLEINKQ NQQFKLNTKRELELARKIQKNSLTEPIVNDQVQIDSYYNASSELSGDLYGYYQIDEHR YGIIILDVMGHGISSALITMSLHPLFQRQITQGLSPVKVMKELDRHLHSLFQNDEEAR HYCTAIYLEIDIARQRIDYVNAGHPPALWQDDSGTQHLLHATSPPIGMFEDLEFQSSS LSYTEDGRLLLYTDGVMDPTASCYLFDLLKDHPDSPIADLKEKILTSLQHQKEAHHKS DDECFILVDVK*" /label="rsbP CDS" gene 3015295..3016506 /gene="rsbP" /locus_tag="BSU_34110" /old_locus_tag="BSU34110" /label="rsbP gene" downshifts 3016493 /Source="Nicolas_upshifts" /id="D1774" /incds=0 /nref=181 /ntot=246 /MaxReadThrough="0.90827" /MaxDrop="5.41923" /score="26.3528321" /energy="-17.8" /TU="NA" /idTUdmin="U2692" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(3016560..3017849) /gene="ganB" /locus_tag="BSU_34120" /old_locus_tag="BSU34120" /EC_number="3.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11682178, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11682178, 17056685, 27501980; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-beta-1,4-galactanase" /protein_id="NP_391292.2" /db_xref="EnsemblGenomes-Gn:BSU34120" /db_xref="EnsemblGenomes-Tr:CAB15417" /db_xref="GOA:O07013" /db_xref="InterPro:IPR011683" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12440" /db_xref="UniProtKB/Swiss-Prot:O07013" /translation="MKSKVKMFFAAAIVWSACSSTGYAAAIEKEKHVSELRAEDLFVK KVEGMNKDFIKGADVSSVIALENSGVTFYNTNGKRQDIFTTLKQAGVNYVRVRIWNHP YDSNGNGYGGGNNDVQKAIEIGKRATANGMKVLADFHYSDFWADPAKQKVPKAWANLS FEAKKAKLYEYTKQSLQKMIKEGVDIGMVQVGNETTGGFAGETDWTKMCQLFNEGSRA VRETNSNILVALHFTNPETAGRYSFIAETLSKNKVDYDVFASSYYPFWHGTLQNLTSV LKAVANTYGKKVMVAETSYTYTAEDGDGHGNTAPKSGQTLPYPISVQGQATAVRDVME AVANTGKAGLGVFYWEPAWIPVGPKTQIEKNKVLWETYGSGWASSYAAEYDPEDAGKW YGGSAVDNQALFDFNGHPLPSLQVFQYAESGHIPKKR*" /label="ganB CDS" gene complement(3016560..3017849) /gene="ganB" /locus_tag="BSU_34120" /old_locus_tag="BSU34120" /label="ganB gene" CDS complement(3017929..3019992) /gene="ganA" /locus_tag="BSU_34130" /old_locus_tag="BSU34130" /EC_number="3.2.1.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9287030, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9287030, 17056685, 27501980; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="short chain beta-1,4-galacto-oligosaccharides beta-galactosidase (beta-galacto-pyranoside hydrolase)" /protein_id="NP_391293.1" /db_xref="EnsemblGenomes-Gn:BSU34130" /db_xref="EnsemblGenomes-Tr:CAB15418" /db_xref="GOA:O07012" /db_xref="InterPro:IPR003476" /db_xref="InterPro:IPR013529" /db_xref="InterPro:IPR013738" /db_xref="InterPro:IPR013739" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12439" /db_xref="UniProtKB/Swiss-Prot:O07012" /translation="MMSKLEKTHVTKAKFMLHGGDYNPDQWLDRPDILADDIKLMKLS HTNTFSVGIFAWSALEPEEGVYQFEWLDDIFERIHSIGGRVILATPSGARPAWLSQTY PEVLRVNASRVKQLHGGRHNHCLTSKVYREKTRHINRLLAERYGHHPALLMWHISNEY GGDCHCDLCQHAFREWLKSKYDNSLKTLNHAWWTPFWSHTFNDWSQIESPSPIGENGL HGLNLDWRRFVTDQTISFYENEIIPLKELTPDIPITTNFMADTPDLIPYQGLDYSKFA KHVDAISWDAYPVWHNDWESTADLAMKVGFINDLYRSLKQQPFLLMECTPSAVNWHNV NKAKRPGMNLLSSMQMIAHGSDSVLYFQYRKSRGSSEKLHGAVVDHDNSPKNRVFQEV AKVGETLERLSEVVGTKRPAQTAILYDWENHWALEDAQGFAKATKRYPQTLQQHYRTF WEHDIPVDVITKEQDFSPYKLLIVPMLYLISEDTVSRLKAFTADGGTLVMTYISGVVN EHDLTYTGGWHPDLQAIFGVEPLETDTLYPKDRNAVSYRSQIYEMKDYATVIDVKTAS VEAVYQEDFYARTPAVTSHEYQQGKAYFIGARLEDQFQRDFYEGLITDLSLSPVFPVR HGKGVSVQARQDQDNDYIFVMNFTEEKQLVTFDQSVKDIMTGDILSGDLTMEKYEVRI VVNTH*" /label="ganA CDS" gene complement(3017929..3019992) /gene="ganA" /locus_tag="BSU_34130" /old_locus_tag="BSU34130" /label="ganA gene" CDS complement(3020011..3020862) /gene="ganQ" /locus_tag="BSU_34140" /old_locus_tag="BSU34140" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17056685, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="galacto-oligosaccharides (galactan) oligomer permease" /protein_id="NP_391294.1" /db_xref="EnsemblGenomes-Gn:BSU34140" /db_xref="EnsemblGenomes-Tr:CAB15419" /db_xref="GOA:O07011" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12438" /db_xref="UniProtKB/Swiss-Prot:O07011" /translation="MLADMKVRRYIRLLFSYLLLAFMAVIIVYPLLWTAGASFNPGNS LISTSIIPKHPTFDHYKELFAGKESLQYVQWYVNSMKISLFTMAGSLLCVTFTAYAFS RFRFKGRKYALTLFLLLQMIPQFSALIALFVLAQILGMINSHWLLILLYIGGLIPMNT YLMKGYMDSIPMDLDESAKIDGASSTRIFFQIILPLSKPMAAVVAMNGFTGPLGDFVL SSTILRTPESYTLPVGLFNLVNDVMGASYTTFAAGALLISIPVAVIFIMLQKNFVSGL TAGGTKG*" /label="ganQ CDS" gene complement(3020011..3020862) /gene="ganQ" /locus_tag="BSU_34140" /old_locus_tag="BSU34140" /label="ganQ gene" CDS complement(3020866..3022122) /gene="ganP" /locus_tag="BSU_34150" /old_locus_tag="BSU34150" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11160890, 15849754, 16850406, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160890, 15849754, 16850406, 17056685, 27501980; Product type t : transporter" /codon_start=1 /transl_table=11 /product="galacto-oligosaccharides (galactan) oligomer permease" /protein_id="NP_391295.1" /db_xref="EnsemblGenomes-Gn:BSU34150" /db_xref="EnsemblGenomes-Tr:CAB15420" /db_xref="GOA:O32261" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12437" /db_xref="UniProtKB/Swiss-Prot:O32261" /translation="MQHRQVALLLSIIPGLGQFYNKQWIKGIVFLFLGASFFAVFGDL LNMGFWGIFTLGTEVPRDNSVFLLAEGIIAVIVTCFGLAVYYVNLRDAFQSGKQRDEN KPLSSLKEQYQHIISEGYPYVVSGPSLFILIFAVIFPILFSFALAFTNYDLYHSPPAK LIDWVGFQTFANIFTVDIWRSTFFDVLAWTVVWTLAASTLQVTLGIFLAIIVNQKDLR FKRFFRTILILPWAVPGFVTILIFAGLFNDSFGAMNHDILAFFGIDPLPWMTDANWSR LALILMQGWLGFPYIFLVSTGVLQSIPDDLYEAATIDGASVFSKLRYITLPMVFIAMA PIIITQFTFNFNNFNIIYLFNGGGPAVTGSTAGGTDILVSWIYKLTMQSSQYSLAAAL TILLSVFVISIALWQFRQTKSFKEEA*" /label="ganP CDS" gene complement(3020866..3022122) /gene="ganP" /locus_tag="BSU_34150" /old_locus_tag="BSU34150" /label="ganP gene" CDS complement(3022162..3023427) /gene="ganS" /locus_tag="BSU_34160" /old_locus_tag="BSU34160" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11682178, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11682178, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="polygalactose / cyclodextrin-binding lipoprotein" /protein_id="NP_391296.1" /db_xref="EnsemblGenomes-Gn:BSU34160" /db_xref="EnsemblGenomes-Tr:CAB15421" /db_xref="GOA:O07009" /db_xref="InterPro:IPR006060" /db_xref="SubtiList:BG12436" /db_xref="UniProtKB/Swiss-Prot:O07009" /translation="MKMAKKCSVFMLCAAVSLSLAACGPKESSSAKSSSKGSELVVWE DKEKSNGIKDAVAAFEKEHDVKVKVVEKPYAKQIEDLRMDGPAGTGPDVLTMPGDQIG TAVTEGLLKELHVKKDVQSLYTDASIQSQMVDQKLYGLPKAVETTVLFYNKDLITEKE LPKTLEEWYDYSKKTADGSKFGFLALFDQIYYAESVMSGYGGYIFGKAKDGSYNPSDI GINNEGAVKGAALIQKFYKDGLFPAGIIGEQGINVLESLFTEGKAAAIISGPWNVEAF SNAGINYGITKLPKLENGKNMSSFIGVKSYNVSAFSKNEELAQELAVFLANEKNSKTR YEETKEVPAVKSLANDPAIMKSEAARAVTEQSRFSEPTPNIPEMNEIWTPADSALQTV ATGKADPKQALDQAAETAKGQIKAKHSGK*" /label="ganS CDS" gene complement(3022162..3023427) /gene="ganS" /locus_tag="BSU_34160" /old_locus_tag="BSU34160" /label="ganS gene" promotor_-10 complement(3023459..3023478) /Source="Nicolas_upshift_promotors" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3023481) /Source="Nicolas_upshifts" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3023493..3023500) /Source="Nicolas_upshift_promotors" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3023568..3024560) /gene="ganR" /locus_tag="BSU_34170" /old_locus_tag="BSU34170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2104611, 9287030, 10486575, 17056685, 27501980, 28617843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9287030, 10486575, 17056685, 27501980, 28617843; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the galactan degradation operon (GanR / beta-1,4-galactobiose)" /protein_id="NP_391297.1" /db_xref="EnsemblGenomes-Gn:BSU34170" /db_xref="EnsemblGenomes-Tr:CAB15422" /db_xref="GOA:O07008" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12435" /db_xref="UniProtKB/Swiss-Prot:O07008" /translation="MATIKDIAQEAGFSISTVSRVLNNDESLSVPDETREKIYEAAEK LNYRKKTVRPLVKHIAFLYWLTDKEELEDVYFKTMRLEVEKLAKAFNVDMTTYKIADG IESIPEHTEGFIAVGTFSDEELAFLRNLTENGVFIDSTPDPDHFDSVRPDLAQMTRKT VNILTEKGHKSIGFIGGTYKNPNTNQDEMDIREQTFRSYMREKAMLDERYIFCHRGFS VENGYRLMSAAIDTLGDQLPTAFMIAADPIAVGCLQALNEKGIAIPNRVSIVSINNIS FAKYVSPPLTTFHIDIHELCKNAVQLLLEQVQDKRRTVKTLYVGAELIVRKSMN*" /label="ganR CDS" gene complement(3023568..3024560) /gene="ganR" /locus_tag="BSU_34170" /old_locus_tag="BSU34170" /label="ganR gene" downshifts complement(3023602) /Source="Nicolas_upshifts" /id="D1775" /incds=0 /nref=2 /ntot=55 /MaxReadThrough="1.40325" /MaxDrop="2.80992" /score="14.7399792" /energy="-8.3" /TU="NA" /idTUdmin="U2694" /TUdmin=1111 /isTUend="FALSE" /label="downshifts" S_feature complement(3024690..3024739) /Source="Nicolas_S_feature" /locus_tag="new_3509781_3509830_c" /HighExp="Sw, BC, M0t90, M40t90, B60, Lbstat, Lbtran, S2, B36, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29208099999999998" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1307" downshifts complement(3024713) /Source="Nicolas_upshifts" /id="D1776" /incds=0 /nref=88 /ntot=240 /MaxReadThrough="1.88481" /MaxDrop="5.0699" /score="7.28170345" /energy="-13.7" /TU="NA" /idTUdmin="U2694" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3024740..3025399) /gene="lutR" /locus_tag="BSU_34180" /old_locus_tag="BSU34180" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18604637, 24196425, 25031425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18604637, 24196425, 25031425; Product type r: regulator" /codon_start=1 /transl_table=11 /product="L-lactate utilization global transcriptional regulator (GntR family)" /protein_id="NP_391298.2" /db_xref="EnsemblGenomes-Gn:BSU34180" /db_xref="EnsemblGenomes-Tr:CAB15423" /db_xref="GOA:O07007" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12434" /db_xref="UniProtKB/Swiss-Prot:O07007" /translation="MIKNGELKPGDKLDSVQALAESFQVSRSAVREALSALKAMGLVE MKQGEGTYLKEFELNQISQPLSAALLMKKEDVKQLLEVRKLLEIGVASLAAEKRTEAD LERIQDALKEMGSIEADGELGEKADFAFHLALADASQNELLKHLMNHVSSLLLETMRE TRKIWLFSKKTSVQRLYEEHERIYNAVAAGNGAQAEAAMLAHLTNVEDVLSGYFEENV Q*" /label="lutR CDS" gene complement(3024740..3025399) /gene="lutR" /locus_tag="BSU_34180" /old_locus_tag="BSU34180" /label="lutR gene" S_feature complement(3025400..3025505) /Source="Nicolas_S_feature" /locus_tag="new_3510491_3510596_c" /HighExp="M0t90, Lbstat, BC, M40t90, Lbtran, Sw, S2, B60, ferm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.69672000000000001" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1308" promotor_-10 complement(3025497..3025516) /Source="Nicolas_upshift_promotors" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3025506) /Source="Nicolas_upshifts" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3025531..3025534) /Source="Nicolas_upshift_promotors" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3025558..3025565 /Source="Nicolas_upshift_promotors" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3025580..3025599 /Source="Nicolas_upshift_promotors" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3025580 /Source="Nicolas_upshifts" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="upshifts" S_feature 3025583..3025688 /Source="Nicolas_S_feature" /locus_tag="new_3510674_3510779" /HighExp="T1.30H, S1, T1.0H, M40t90, T2.0H, M0t90, T3.0H, T2.30H, T0.30H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1309" promotor_-10 complement(3025589..3025606) /Source="Nicolas_upshift_promotors" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3025593) /Source="Nicolas_upshifts" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3025614..3025620) /Source="Nicolas_upshift_promotors" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3025689..3027380 /gene="lutP" /locus_tag="BSU_34190" /old_locus_tag="BSU34190" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 25031425; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-lactate permease" /protein_id="NP_391299.1" /db_xref="EnsemblGenomes-Gn:BSU34190" /db_xref="EnsemblGenomes-Tr:CAB15424" /db_xref="GOA:P71067" /db_xref="InterPro:IPR003804" /db_xref="SubtiList:BG11875" /db_xref="UniProtKB/Swiss-Prot:P71067" /translation="MQWTQAYTPIGGNLLLSALAALVPIIFFFWALAIKRMKGYTAGL ATLGIALIIAVLVYRMPAEKALMSATQGAVYGLLPIGWIIVTSVFLYKITVKTGQFDI IRSSVLSITDDRRLQALLIAFSFGAFLEGAAGFGAPVAISAALLVGLGFNPLYAAGIC LIANTAPVAFGAIGIPITAVEGPTGIPAMEISQMVGRQLPFLSVFIPLYLIIIMSGFR KALEIWPAILVSGVSFAVVQYLSSNFLGPELPDVLSALVSMAALAVFLKWWKPKTTFR FAGEQESAASIETARTNPAAPAYRGGQIFKAWSPFLLLTAMISVWGIPSVKSALTGHY EGSAVFLKWLNAVGEKLTFSPGVPFLNNQIVNADGTPIEAVYKLEVLGSAGTAILIAA VLSKFITAISWKDWGTVFKETVQELKLPILTIASVVGFAYVTNSSGMSTTLGMTLALT GSMFTFFSPVLGWLGVFITGSDTSANLLFGNLQKVTALSVGMDPVLSVAANSSGGVTG KMISPQSIAVACAAVGLAGKESDLFRFTIKHSLFLLLLVCIITFLQHHVFSWMIP*" /label="lutP CDS" gene 3025689..3027380 /gene="lutP" /locus_tag="BSU_34190" /old_locus_tag="BSU34190" /label="lutP gene" downshifts 3027365 /Source="Nicolas_upshifts" /id="D1777" /incds=0 /nref=153 /ntot=245 /MaxReadThrough="4.82757" /MaxDrop="5.44233" /score="20.8815301" /energy="-11.7" /TU="NA" /idTUdmin="U2695" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3027407..3028717) /gene="sigL" /locus_tag="BSU_34200" /old_locus_tag="BSU34200" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11274109, 12533460, 12634342, 16166551, 16585774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 12533460, 12634342, 16166551, 16585774; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-54 factor (sigma-L)" /protein_id="NP_391300.1" /db_xref="EnsemblGenomes-Gn:BSU34200" /db_xref="EnsemblGenomes-Tr:CAB15425" /db_xref="GOA:P24219" /db_xref="InterPro:IPR000394" /db_xref="InterPro:IPR007046" /db_xref="InterPro:IPR007634" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10748" /db_xref="UniProtKB/Swiss-Prot:P24219" /translation="MDMKLQQVQVLKPQLTQELRQAITLLGYHSAELAEYIDELSLEN PLIERKETDTPPLSYHKTNKNRMNAQEAGLQLSNPQKTLQDALKQQSLDMNLTNTEKK IFNYLIHSLDSNGYLEEDIEEAARRLSVSAKEAEAVLAKLQSLEPAGIGARSLQECIL LQLQRLPNRNEQAEMLVSAHFDAFAQKKWKTLSVETGIPLHTIQDISDDIAALHPRPG LLFARPEQDVYIEPDIFITVKNGHIAAELNTRSFPEIDLHPQYRTLLSSGSCQDTVSY LSAKYQEWRWLSRALRQRKQTITRIINELITRQKDFFLKGRSAMKPLTLREVADCLSL HESTVSRAIKGKTIQTPYGLFEMKLFFSAKAEASGDGDASNYAVKTHLENLINQEDKT KPLSDQKLVDLLYEQHGIQISRRTVAKYRDQMNIPSSAARKRYK*" /label="sigL CDS" gene complement(3027407..3028717) /gene="sigL" /locus_tag="BSU_34200" /old_locus_tag="BSU34200" /label="sigL gene" S_feature 3027410..3028480 /Source="Nicolas_S_feature" /locus_tag="new_3512501_3513571" /HighExp="M9-stat, T1.30H, S1, Sw, T1.0H, T2.0H, T0.30H, G/S, T3.30H, T2.30H" /AntisenseName="sigL" /AntisenseCor="0.63927172079726402" /AntisenseRegPval="-31.6" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1310" downshifts complement(3027419) /Source="Nicolas_upshifts" /id="D1778" /incds=0 /nref=62 /ntot=219 /MaxReadThrough="2.33779" /MaxDrop="5.56948" /score="28.2409666" /energy="-11.7" /TU="NA" /idTUdmin="U2698" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 3028537..3028556 /Source="Nicolas_upshift_promotors" /id="U2697" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2629 /SigmaFactorBS="tttgcggattacttaattgaaggcccgcttcctgtgcattca tcctgtttttgtttgtttTATGGTAAGATAGTGGCGGTgtgtctgtttcctttcgttc a" /listShort="S1311, yvfG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 3028537..3028795 /Source="Nicolas_S_feature" /locus_tag="new_3513628_3513886" /HighExp="LBGstat, LBGexp, G180, Paraq, H2O2, LBGtran, Oxctl, Lbexp, dia0, HPh" /AntisenseName="sigL" /AntisenseCor="-0.50245218771496702" /AntisenseRegPval="-17.899999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1311" upshifts 3028537 /Source="Nicolas_upshifts" /id="U2697" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2629 /SigmaFactorBS="tttgcggattacttaattgaaggcccgcttcctgtgcattca tcctgtttttgtttgtttTATGGTAAGATAGTGGCGGTgtgtctgtttcctttcgttc a" /listShort="S1311, yvfG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3028731..3028750) /Source="Nicolas_upshift_promotors" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3028746) /Source="Nicolas_upshifts" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3028765..3028768) /Source="Nicolas_upshift_promotors" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3028796..3029014 /gene="yvfG" /locus_tag="BSU_34210" /old_locus_tag="BSU34210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391301.1" /db_xref="EnsemblGenomes-Gn:BSU34210" /db_xref="EnsemblGenomes-Tr:CAB15426" /db_xref="InterPro:IPR018590" /db_xref="PDB:2GSV" /db_xref="PDB:2JS1" /db_xref="SubtiList:BG11876" /db_xref="UniProtKB/Swiss-Prot:P71066" /translation="MSELFSVPYFIENLKQHIEMNQSEDKIHAMNSYYRSVVSTLVQD QLTKNAVVLKRIQHLDEAYNKVKRGESK*" /label="yvfG CDS" gene 3028796..3029014 /gene="yvfG" /locus_tag="BSU_34210" /old_locus_tag="BSU34210" /label="yvfG gene" downshifts 3028993 /Source="Nicolas_upshifts" /id="D1779" /incds=0 /nref=53 /ntot=250 /MaxReadThrough="3.27525" /MaxDrop="4.21929" /score="-0.306638574" /energy="-13.4" /TU="U2697" /idTUdmin="U2697" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" CDS complement(3029024..3029992) /gene="epsO" /locus_tag="BSU_34220" /old_locus_tag="BSU34220" /EC_number="2.-.-.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1097084, 115661000, 20720312, 23378512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvyl transferase for matrix biofilm formation" /protein_id="NP_391302.1" /db_xref="EnsemblGenomes-Gn:BSU34220" /db_xref="EnsemblGenomes-Tr:CAB15427" /db_xref="GOA:P71065" /db_xref="InterPro:IPR007345" /db_xref="SubtiList:BG11874" /db_xref="UniProtKB/Swiss-Prot:P71065" /translation="MDSKHSMISLKQKLSGLLDVIPKQSEIIYADYPLYGNVGDLFIM KGTEAFFKEHGIRVRKRWNPDNFPIGRKLDPNLIIVCQGGGNFGDLYPYYQGFREKIV QTYPNHKIVILPQSIYFQNKDNLKRTAEIFSKHANLHIMTREKASYATAQAYFTTNHI QLLPDMAHQLFPVIPTQQPSNQKLRFIRTDHEANQALQEHAEAESYDWRTVLSASDRR TIAFLQTLNVLNKKAGNPLPIAYIWEKYSDYIVQKAIRFFSRYESVETSRLHGHILSS LLQKENTVIDNSYGKNANYFHTWMEGVPSTRLIQHASKKENLPAHM*" /label="epsO CDS" gene complement(3029024..3029992) /gene="epsO" /locus_tag="BSU_34220" /old_locus_tag="BSU34220" /label="epsO gene" CDS complement(3029971..3031137) /gene="epsN" /locus_tag="BSU_34230" /old_locus_tag="BSU34230" /EC_number="2.6.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15661000, 20720312, 23378512, 27084765, 27897378; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminotransferase involved in biofilm matrix formation" /protein_id="NP_391303.2" /db_xref="EnsemblGenomes-Gn:BSU34230" /db_xref="EnsemblGenomes-Tr:CAB15428" /db_xref="GOA:Q795J3" /db_xref="InterPro:IPR000653" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11873" /db_xref="UniProtKB/Swiss-Prot:Q795J3" /translation="MHKKIYLSPPHMSGREQHYISEAFRSNWIAPLGPLVNSFEEQLA ERVGVKAAAAVGSGTAAIHLALRLLEVKEGDSVFCQSFTFVATANPILYEKAVPVFID SEPDTWNMSPTALERALEEAKRNGTLPKAVIAVNLYGQSAKMDEIVSLCDAYGVPVIE DAAESLGTVYKGKQSGTFGRFGIFSFNGNKIITTSGGGMLVSNDEAAIEKARFLASQA REPAVHYQHSEIGHNYRLSNILAGVGIAQLEVLDERVEKRRTIFTRYKNALGHLDGVR FMPEYAAGVSNRWLTTLTLDNGLSPYDIVQRLAEENIEARPLWKPLHTQPLFDPALFY SHEDTGSVCEDLFKRGICLPSGSNMTEDEQGRVIEVLLHLFHTVEVKKWTASIR*" /label="epsN CDS" gene complement(3029971..3031137) /gene="epsN" /locus_tag="BSU_34230" /old_locus_tag="BSU34230" /label="epsN gene" CDS complement(3031142..3031792) /gene="epsM" /locus_tag="BSU_34240" /old_locus_tag="BSU34240" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15661000, 27897378; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative O-acetyltransferase involved in biofilmmatrix formation" /protein_id="NP_391304.1" /db_xref="EnsemblGenomes-Gn:BSU34240" /db_xref="EnsemblGenomes-Tr:CAB15429" /db_xref="GOA:P71063" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR020019" /db_xref="SubtiList:BG11872" /db_xref="UniProtKB/Swiss-Prot:P71063" /translation="MKNVAIVGDGGHGKVIRELINARSDTRLAAVLDDKFKTFEGGKE WYTGPPKAVTELRRLIPDVLFLIAVGNNSVRKQLAERLGLGKDDFITLIHPSAIVSKS AVIGEGTVIMAGAIIQADARIGAHCIINTGAVAEHDNQISDYVHLSPRATLSGAVSVQ EGAHVGTGASVIPQIIIGAWSIVGAGSAVIRSIPDRVTAAGAPARIISSIQTSNKG*" /label="epsM CDS" gene complement(3031142..3031792) /gene="epsM" /locus_tag="BSU_34240" /old_locus_tag="BSU34240" /label="epsM gene" CDS complement(3031789..3032397) /gene="epsL" /locus_tag="BSU_34250" /old_locus_tag="BSU34250" /EC_number="2.7.-.-" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 15661000, 23378512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase involved in extracellular matrix synthesis" /protein_id="NP_391305.1" /db_xref="EnsemblGenomes-Gn:BSU34250" /db_xref="EnsemblGenomes-Tr:CAB15430" /db_xref="GOA:P71062" /db_xref="InterPro:IPR003362" /db_xref="SubtiList:BG11871" /db_xref="UniProtKB/Swiss-Prot:P71062" /translation="MILKRLFDLTAAIFLLCCTSVIILFTIAVVRLKIGSPVFFKQVR PGLHGKPFTLYKFRTMTDERDSKGNLLPDEVRLTKTGRLIRKLSIDELPQLLNVLKGD LSLVGPRPLLMDYLPLYTEKQARRHEVKPGITGWAQINGRNAISWEKKFELDVWYVDN WSFFLDLKILCLTVRKVLVSEGIQQTNHVTAERFTGSGDVSS*" /label="epsL CDS" gene complement(3031789..3032397) /gene="epsL" /locus_tag="BSU_34250" /old_locus_tag="BSU34250" /label="epsL gene" CDS complement(3032394..3033911) /gene="epsK" /locus_tag="BSU_34265" /old_locus_tag="BSU34265" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 15661000, 15849754, 16850406, 26078454, 27897378; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative extracellular matrix component exporter; putative cyclic di-GMP receptor" /protein_id="YP_003097789.1" /db_xref="EnsemblGenomes-Gn:BSU34265" /db_xref="EnsemblGenomes-Tr:CAX52695" /db_xref="GOA:P71060" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR029303" /db_xref="UniProtKB/Swiss-Prot:P71060" /translation="MKFTINFSANLTAFLLSVFLSVWMTPFIVKTLGVEAFGFVHLTQ NVINYFSVITVALSSVVVRFFSVAAHRGEREKANAYISNYLAASVLISLLLLLPLAGS AFFIDRVMNVPQALLADVRLSILIGSVLFILTFLMAGFGAAPFYANRLYITSSIQAVQ MLIRVLSVLLLFACFAPKIWQIQLAALAGAVIASVLSFYFFKKLIPWFSFRMKDLSFR TSKELFQAGAWSSVNQIGVLLFLQIDLLTANLMLGASASGKYAAIIQFPLLLRSLAGT VASLFAPIMTSYYSKGDMEGLMNYANKAVRLNGLLLALPAALLGGLAGPFLTIWLGPS FSTIAPLLFIHAGYLVVSLAFMPLFYIWTAFNQQKTPAIVTLLLGAVNVVLAVTLSGP AHLGLYGITLAGAISLILKNAIFTPLYVSRITGYKKHVFLKGIIGPLSAAVFAWTVCK AIQFIVKIDSWPSLIATGVTVSFCYAVFAFMLVCTKEERQLVLKRFRKTKGAVNL*" /label="epsK CDS" gene complement(3032394..3033911) /gene="epsK" /locus_tag="BSU_34265" /old_locus_tag="BSU34265" /label="epsK gene" CDS complement(3033908..3034942) /gene="epsJ" /locus_tag="BSU_34280" /old_locus_tag="BSU34280" /EC_number="2.4.-.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15661000, 20720312, 26078454, 27897378; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyl transferase involved in biofilm matrix formation" /protein_id="NP_391308.1" /db_xref="EnsemblGenomes-Gn:BSU34280" /db_xref="EnsemblGenomes-Tr:CAB15433" /db_xref="GOA:P71059" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11868" /db_xref="UniProtKB/Swiss-Prot:P71059" /translation="MIPLVSIIVPMYNVEPFIEECIDSLLRQTLSDIEIILVNDGTPD RSGEIAEDYAKRDARIRVIHQANGGLSSARNTGIKAARGTYIGFVDGDDYVSSAMFQR LTEEAEQNQLDIVGCGFYKQSSDRRTYVPPQLEANRVLTKPEMTEQLKHAHETRFIWY VWRYLYRRELFERANLLFDEDIRFAEDSPFNLSAFREAERVKMLDEGLYIYRENPNSL TEIPYKPAMDEHLQKQYQAKIAFYNHYGLAGACKEDLNVYICRHQLPMLLANACASPN SPKDIKKKIRQILSYDMVRQAVRHTPFQHEKLLRGERLVLALCKWRLTFLIKLFFEQR GTMKGSAKQA*" /label="epsJ CDS" gene complement(3033908..3034942) /gene="epsJ" /locus_tag="BSU_34280" /old_locus_tag="BSU34280" /label="epsJ gene" CDS complement(3034939..3036015) /gene="epsI" /locus_tag="BSU_34290" /old_locus_tag="BSU34290" /EC_number="2.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15173185, 15661000, 20720312, 26078454; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative polysaccharide pyruvyl transferase involved in biofilm matrix formation" /protein_id="NP_391309.1" /db_xref="EnsemblGenomes-Gn:BSU34290" /db_xref="EnsemblGenomes-Tr:CAB15434" /db_xref="GOA:P71058" /db_xref="InterPro:IPR007345" /db_xref="SubtiList:BG11867" /db_xref="UniProtKB/Swiss-Prot:P71058" /translation="MSLQSLKINFAEWLLLKVKYPSQYWLGAADQPVKAAAHQKKIIL TLLPSHDNLGDHAIAYASKAFLEQEYPDFDIVEVDMKDIYKSAKSLIRSRHPEDMVFI IGGGNMGDLYRYEEWTRRFIIKTFHDYRVVQLPATAHFSDTKKGRKELKRAQKIYNAH PGLLLMARDETTYQFMKQHFQEKTILKQPDMVLYLDRSKAPAEREGVYMCLREDQESV LQEEQRNRVKAALCEEFGEIKSFTTTIGRRVSRDTREHELEALWSKLQSAEAVVTDRL HGMIFCALTGTPCVVIRSFDHKVMEGYQWLKDIPFMKLIEHPEPERVTAAVNELLTKE TSRAGFPRDVYFKGLRDKISGEAQ*" /label="epsI CDS" gene complement(3034939..3036015) /gene="epsI" /locus_tag="BSU_34290" /old_locus_tag="BSU34290" /label="epsI gene" CDS complement(3036020..3037054) /gene="epsH" /locus_tag="BSU_34300" /old_locus_tag="BSU34300" /EC_number="2.-.-.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15083514, 15661000; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase involved in biofilmformation" /protein_id="NP_391310.1" /db_xref="EnsemblGenomes-Gn:BSU34300" /db_xref="EnsemblGenomes-Tr:CAB15435" /db_xref="GOA:P71057" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11866" /db_xref="UniProtKB/Swiss-Prot:P71057" /translation="METPAVSLLVAVYNTETYIRTCLESLRNQTMDNIEIIIVNDGSA DASPDIAEEYAKMDNRFKVIHQENQGLGAVRNKGIEAARGEFIAFIDSDDWIEPDYCE QMLRTAGDETDLVICNYAAEFEDTGKTMDSDIAQTYQDQPKEHYIKALFEGKVRGFSW NKLYRRSMIEAHRLSFPLRGELEHVEDQFFSFRAHFFARSVSYVKTPLYHYRIHLSSI VQRYQKKLFESGLALYETNAAFLQENNKLEEYRKELDTFIVLHSSICMLNEWKTSGSR RLFEKLRNVGVICADPVFQESLSKTGTAPFDAKRSCLLLMAKYRMIPFVAMASAVYQR VIEYKMRNRG*" /label="epsH CDS" gene complement(3036020..3037054) /gene="epsH" /locus_tag="BSU_34300" /old_locus_tag="BSU34300" /label="epsH gene" CDS complement(3037079..3038182) /gene="epsG" /locus_tag="BSU_34310" /old_locus_tag="BSU34310" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15175311, 15661000, 15849754, 16850406, 22451411" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15175311, 15661000, 15849754, 16850406, 22451411; Product type f: factor" /codon_start=1 /transl_table=11 /product="biofilm extracellular matrix formation chain-length determining factor" /protein_id="NP_391311.1" /db_xref="EnsemblGenomes-Gn:BSU34310" /db_xref="EnsemblGenomes-Tr:CAB15436" /db_xref="GOA:P71056" /db_xref="SubtiList:BG11865" /db_xref="UniProtKB/Swiss-Prot:P71056" /translation="MIVYAVNMGIVFIWSWFAKMCGGRDDSLATGYRPNKLLIWIPLA SLVLVSGLRYRVGTDFQTYTLLYELAGDYQNVWQIFGFGTAKTATDPGFTALLWLMNF ITEDPQIMYFTVAVVTYSFIMKTLADYGRPFELSVFLFLGTFHYYASFNGIRQYMVAA VLFWAIRYIISGNWKRYFLIVLVSSLFHSSALIMIPVYFIVRRKAWSPAIFGLSALFL GMTFLYQKFISVFVVVLENSSYSHYEKWLMTNTNGMNVIKIAVLVLPLFLAFCYKERL RSLWPQIDIVVNLCLLGFLFGLLATKDVIFARFNIYFGLYQMILVPYFVRIFDEKSNA LIYIAIVVCYFLYSYLLMPVDSSVLPYRTIFSR*" /label="epsG CDS" gene complement(3037079..3038182) /gene="epsG" /locus_tag="BSU_34310" /old_locus_tag="BSU34310" /label="epsG gene" CDS complement(3038179..3039333) /gene="epsF" /locus_tag="BSU_34320" /old_locus_tag="BSU34320" /EC_number="2.-.-.-" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 15661000, 22451411; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase involved in matrix formation (chain-length determination)" /protein_id="NP_391312.1" /db_xref="EnsemblGenomes-Gn:BSU34320" /db_xref="EnsemblGenomes-Tr:CAB15437" /db_xref="GOA:P71055" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11864" /db_xref="UniProtKB/Swiss-Prot:P71055" /translation="MNSSQKRVLHVLSGMNRGGAETMVMNLYRKMDKSKVQFDFLTYR NDPCAYDEEILSLGGRLFYVPSIGQSNPLTFVRNVRNAIKENGPFSAVHAHTDFQTGF IALAARLAGVPVRVCHSHNTSWKTGFNWKDRLQLLVFRRLILANATALCACGEDAGRF LFGQSNMERERVHLLPNGIDLELFAPNGQAADEEKAARGIAADRLIIGHVARFHEVKN HAFLLKLAAHLKERGIRFQLVLAGDGPLCGEIEEEARQQNLLSDVLFLGTEERIHELM RTFDVFVMPSLYEGLPVVLVEAQASGLPCIISDSITEKVDAGLGLVTRLSLSEPISVW AETIARAAAAGRPKREFIKETLAQLGYDAQQNVGALLNVYNISTEKDHNR*" /label="epsF CDS" gene complement(3038179..3039333) /gene="epsF" /locus_tag="BSU_34320" /old_locus_tag="BSU34320" /label="epsF gene" CDS complement(3039326..3040162) /gene="epsE" /locus_tag="BSU_34330" /old_locus_tag="BSU34330" /EC_number="2.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15175311, 15661000, 21170308, 22720735, 23480406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15175311, 15661000, 21170308, 22720735, 23480406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional flagellar clutch and glycosyltransferase acting during biofilm formation" /protein_id="NP_391313.2" /db_xref="EnsemblGenomes-Gn:BSU34330" /db_xref="EnsemblGenomes-Tr:CAB15438" /db_xref="GOA:P71054" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11863" /db_xref="UniProtKB/Swiss-Prot:P71054" /translation="MNSGPKVSVIMGIYNCERTLAESIESILSQSYKNWELILCDDAS TDGTLRIAKQYAAHYSDRIKLIQNKTNKRLAASLNHCLSHATGDYIARQDGDDLSFPR RLEKQVAFLEKHRHYQVVGTGMLVFDEFGVRGARILPSVPEPGIMAKGTPFCHGTIMM RASAYRTLKGYRSVRRTRRMEDIDLWLRFFEEGFRGYNLQEALYKVREDSDAFKRRSF TYSIDNAILVYQACRRLKLPLSDYIYIAKPLIRAFMPAAVMNRYHKKRVMNQKEGLVK HE*" /label="epsE CDS" gene complement(3039326..3040162) /gene="epsE" /locus_tag="BSU_34330" /old_locus_tag="BSU34330" /label="epsE gene" CDS complement(3040159..3041304) /gene="epsD" /locus_tag="BSU_34340" /old_locus_tag="BSU34340" /EC_number="2.4.-.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 15661000, 23378512, 26299781; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative extracellular matrix glycosyltransferase" /protein_id="NP_391314.1" /db_xref="EnsemblGenomes-Gn:BSU34340" /db_xref="EnsemblGenomes-Tr:CAB15439" /db_xref="GOA:P71053" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11862" /db_xref="UniProtKB/Swiss-Prot:P71053" /translation="MTKKILFCATVDYHFKAFHLPYFKWFKQMGWEVHVAANGQTKLP YVDEKFSIPIRRSPFDPQNLAVYRQLKKVIDTYEYDIVHCHTPVGGVLARLAARQARR HGTKVLYTAHGFHFCKGAPMKNWLLYYPVEKWLSAYTDCLITINEEDYIRAKGLQRPG GRTQKIHGIGVNTERFRPVSPIEQQRLREKHGFREDDFILVYPAELNLNKNQKQLIEA AALLKEKIPSLRLVFAGEGAMEHTYQTLAEKLGASAHVCFYGFCSDIHELIQLADVSV ASSIREGLGMNVLEGMAAEQPAIATDNRGHREIIRDGENGFLIKIGDSAAFARRIEQL YHKPELCRKLGQEGRKTALRFSEARTVEEMADIYSAYMDMDTKEKSV*" /label="epsD CDS" gene complement(3040159..3041304) /gene="epsD" /locus_tag="BSU_34340" /old_locus_tag="BSU34340" /label="epsD gene" CDS complement(3041316..3043112) /gene="epsC" /locus_tag="BSU_34350" /old_locus_tag="BSU34350" /EC_number="5.1.3.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15661000, 23378512, 27655338; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UDP-sugar epimerase involved in biofilmmatrix formation" /protein_id="NP_391315.1" /db_xref="EnsemblGenomes-Gn:BSU34350" /db_xref="EnsemblGenomes-Tr:CAB15440" /db_xref="GOA:P71052" /db_xref="InterPro:IPR003869" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11861" /db_xref="UniProtKB/Swiss-Prot:P71052" /translation="MIIALDTYLVLNSVIAGYQFLKDSYQFYDSGALLLTAVSLLLSY HVCAFLFNQYKQVWTYTGLGELIVLLKGITLSAAVTGVIQYAVYHTMFFRLLTACWVL QLLSIGGTRILSRVLNESIRKKRCASSRALIIGAGSGGTLMVRQLLSKDEPDIIPVAF IDDDQTKHKLEIMGLPVIGGKESIMPAVQKLKINYIIIAIPSLRTHELQVLYKECVRT GVSIKIMPHFDEMLLGTRTAGQIRDVKAEDLLGRKPVTLDTSEISNRIKGKTVLVTGA GGSIGSEICRQISAFQPKEIILLGHGENSIHSIYTELNGRFGKHIVFHTEIADVQDRD KMFTLMKKYEPHVVYHAAAHKHVPLMEHNPEEAVKNNIIGTKNVAEAADMSGTETFVL ISSDKAVNPANVMGATKRFAEMIIMNLGKVSRTKFVAVRFGNVLGSRGSVIPIFKKQI EKGGPVTVTHPAMTRYFMTIPEASRLVIQAGALAKGRQIFVLDMGEPVKIVDLAKNLI HLSGYTTEQVPIEFTGIRPGEKMYEELLNKNEVHAEQIFPKIHIGKAVDGDWPVLMRF IEDFHELPEADLRARLFAAINTSEEMTAASVH*" /label="epsC CDS" gene complement(3041316..3043112) /gene="epsC" /locus_tag="BSU_34350" /old_locus_tag="BSU34350" /label="epsC gene" S_feature complement(3043113..3043172) /Source="Nicolas_S_feature" /locus_tag="new_3528204_3528263_c" /HighExp="LoTm, G/S, M9-tran, BMM, MG 150, S3, S2, S4, aero, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.79" /TUlongSig="NA" /TUlongPSig="NA" /label="S1312" promotor_-10 complement(3043146..3043164) /Source="Nicolas_upshift_promotors" /id="U2699" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.79020979020979" /psig="0.79020979020979" /xcortree=2767 /SigmaFactorBS="atacataggacgtattgtcggtttagctgctgccgatttttt ggagagACGAAAAccgccgcagctaaACCGATAAAAGAATTAGGGgggaaaaggttga g" /listShort="S1312, epsC, epsD, epsE, epsF, epsG, epsH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3043172) /Source="Nicolas_upshifts" /id="U2699" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.79020979020979" /psig="0.79020979020979" /xcortree=2767 /SigmaFactorBS="atacataggacgtattgtcggtttagctgctgccgatttttt ggagagACGAAAAccgccgcagctaaACCGATAAAAGAATTAGGGgggaaaaggttga g" /listShort="S1312, epsC, epsD, epsE, epsF, epsG, epsH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3043178..3043184) /Source="Nicolas_upshift_promotors" /id="U2699" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.79020979020979" /psig="0.79020979020979" /xcortree=2767 /SigmaFactorBS="atacataggacgtattgtcggtttagctgctgccgatttttt ggagagACGAAAAccgccgcagctaaACCGATAAAAGAATTAGGGgggaaaaggttga g" /listShort="S1312, epsC, epsD, epsE, epsF, epsG, epsH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3043371..3044054) /gene="epsB" /locus_tag="BSU_34360" /old_locus_tag="BSU34360" /EC_number="2.7.10.2" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15661000, 15741737, 24493247, 26283769, 28950882" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15661000, 15741737, 24493247, 26283769, 28950882; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein tyrosine kinase involved in biofilm matrix formation" /protein_id="NP_391316.1" /db_xref="EnsemblGenomes-Gn:BSU34360" /db_xref="EnsemblGenomes-Tr:CAB15441" /db_xref="GOA:P71051" /db_xref="InterPro:IPR005702" /db_xref="InterPro:IPR025669" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11860" /db_xref="UniProtKB/Swiss-Prot:P71051" /translation="MIFRKKKARRGLAQISVLHNKSVVAEQYRTIRTNIEFSSVQTNL RSILVTSSVPGEGKSFSAANLAAVFAQQQEKKVLLVDADLRKPTINQTFQVDNVTGLT NVLVGNASLSETVQKTPIDNLYVLTSGPTPPNPAELLSSKAMGDLISEIYEQFSLVIF DSPPLLAVADAQILANQTDGSVLVVLSGKTKTDTVLKAKDALEQSNAKLLGALLNKKK MKKSEHYSY*" /label="epsB CDS" gene complement(3043371..3044054) /gene="epsB" /locus_tag="BSU_34360" /old_locus_tag="BSU34360" /label="epsB gene" CDS complement(3044060..3044764) /gene="epsA" /locus_tag="BSU_34370" /old_locus_tag="BSU34370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12970183, 15661000, 23378512, 26283769, 28950882; Product type r : regulator" /codon_start=1 /transl_table=11 /product="modulator of protein tyrosine kinase EpsB involved in biofilm matrix formation" /protein_id="NP_391317.1" /db_xref="EnsemblGenomes-Gn:BSU34370" /db_xref="EnsemblGenomes-Tr:CAB15442" /db_xref="GOA:P71050" /db_xref="InterPro:IPR003856" /db_xref="SubtiList:BG11859" /db_xref="UniProtKB/Swiss-Prot:P71050" /translation="MNENMSFKELYAIVRHRFVLILLITIGVTLIMGFVQFKVISPTY QASTQVLVHESDGEENSNLSDIQRNLQYSSTFQSIMKSTALMEEVKAELHLSESASSL KGKVVTSSENESEIINVAVQDHDPAKAAEIANTLVNKFEKEVDERMNVQGVHILSEAK ASESPMIKPARLRNMVMAFGAAVMGGITLAFFLHFLDDTCKSARQLSERTGLPCLGSV PDVHKGRNRGIKHFGE*" /label="epsA CDS" gene complement(3044060..3044764) /gene="epsA" /locus_tag="BSU_34370" /old_locus_tag="BSU34370" /label="epsA gene" upshifts 3044746 /Source="Nicolas_upshifts" /id="U2700" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1024 /SigmaFactorBS="cgattgtgatgagcagaatcagcacgaatctgtgtctgacaa tCgcatataattctttgaaacTCATATTCTCATTCATGTAttcatagccttcagcctt c" /listShort="slrR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3044749..3044767 /Source="Nicolas_upshift_promotors" /id="U2700" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1024 /SigmaFactorBS="cgattgtgatgagcagaatcagcacgaatctgtgtctgacaa tCgcatataattctttgaaacTCATATTCTCATTCATGTAttcatagccttcagcctt c" /listShort="slrR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature complement(3044765..3044822) /Source="Nicolas_S_feature" /locus_tag="new_3529856_3529913_c" /HighExp="LoTm, BT, S3, G/S, BMM, M9-tran, S4, aero, T1.0H, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.952" /TUlongSig="NA" /TUlongPSig="NA" /label="S1313" promotor_-10 complement(3044818..3044837) /Source="Nicolas_upshift_promotors" /id="U2701" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.441558441558442" /psig="0.952047952047952" /xcortree=2770 /SigmaFactorBS="aagagaacttattggcttattttgcAATTTTTAaataataac gtttTCTTTTATAATCCAATCATTaacagaaaggggcgcgggaagccagccgcgggaa g" /listShort="S1313, epsA, epsB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3044823) /Source="Nicolas_upshifts" /id="U2701" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.441558441558442" /psig="0.952047952047952" /xcortree=2770 /SigmaFactorBS="aagagaacttattggcttattttgcAATTTTTAaataataac gtttTCTTTTATAATCCAATCATTaacagaaaggggcgcgggaagccagccgcgggaa g" /listShort="S1313, epsA, epsB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3044851..3044858) /Source="Nicolas_upshift_promotors" /id="U2701" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.441558441558442" /psig="0.952047952047952" /xcortree=2770 /SigmaFactorBS="aagagaacttattggcttattttgcAATTTTTAaataataac gtttTCTTTTATAATCCAATCATTaacagaaaggggcgcgggaagccagccgcgggaa g" /listShort="S1313, epsA, epsB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3044940..3044945 /Source="Nicolas_upshift_promotors" /id="U2702" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.464535464535465" /psig="0.995004995004995" /xcortree=2771 /SigmaFactorBS="cctctaatttactgcacttcccttattattttaaATTTTAta aagaacgaaaaaTTCCTTATAATGAACGAAATaacgacaggaatagaggagaatttca t" /listShort="slrR" /listLong="pnbA" /label="promotor_-35" promotor_-10 3044960..3044979 /Source="Nicolas_upshift_promotors" /id="U2702" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.464535464535465" /psig="0.995004995004995" /xcortree=2771 /SigmaFactorBS="cctctaatttactgcacttcccttattattttaaATTTTAta aagaacgaaaaaTTCCTTATAATGAACGAAATaacgacaggaatagaggagaatttca t" /listShort="slrR" /listLong="pnbA" /label="promotor_-10" upshifts 3044966 /Source="Nicolas_upshifts" /id="U2702" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.464535464535465" /psig="0.995004995004995" /xcortree=2771 /SigmaFactorBS="cctctaatttactgcacttcccttattattttaaATTTTAta aagaacgaaaaaTTCCTTATAATGAACGAAATaacgacaggaatagaggagaatttca t" /listShort="slrR" /listLong="pnbA" /label="upshifts" CDS 3045010..3045468 /gene="slrR" /locus_tag="BSU_34380" /old_locus_tag="BSU34380" /function="16.5: Explore" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18430133, 18647168, 20923420, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18430133, 18647168, 20923420, 28546427; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of autolysin genes (biofilm formation)" /protein_id="NP_391318.1" /db_xref="EnsemblGenomes-Gn:BSU34380" /db_xref="EnsemblGenomes-Tr:CAB15443" /db_xref="GOA:P71049" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR036281" /db_xref="SubtiList:BG11858" /db_xref="UniProtKB/Swiss-Prot:P71049" /translation="MIGRIIRLYRKRKGYSINQLAVESGVSKSYLSKIERGVHTNPSV QFLKKVSATLEVELTELFDAETMMYEKISGGEEEWRVHLVQAVQAGMEKEELFTFTNR LKKEQPETASYRNRKLTESNIEEWKALMAEAREIGLSVHEVKSFLKTKGR*" /label="slrR CDS" gene 3045010..3045468 /gene="slrR" /locus_tag="BSU_34380" /old_locus_tag="BSU34380" /label="slrR gene" promotor_-35 3045490..3045493 /Source="Nicolas_upshift_promotors" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3045499 /Source="Nicolas_upshifts" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3045510..3045528 /Source="Nicolas_upshift_promotors" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3045544..3047013 /gene="pnbA" /locus_tag="BSU_34390" /old_locus_tag="BSU34390" /EC_number="3.1.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7828905, 15138843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7828905, 15138843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="para-nitrobenzyl esterase (intracellular esterase B)" /protein_id="NP_391319.1" /db_xref="EnsemblGenomes-Gn:BSU34390" /db_xref="EnsemblGenomes-Tr:CAB15444" /db_xref="GOA:P37967" /db_xref="InterPro:IPR000997" /db_xref="InterPro:IPR002018" /db_xref="InterPro:IPR019819" /db_xref="InterPro:IPR019826" /db_xref="InterPro:IPR029058" /db_xref="PDB:1C7I" /db_xref="PDB:1C7J" /db_xref="PDB:1QE3" /db_xref="SubtiList:BG11844" /db_xref="UniProtKB/Swiss-Prot:P37967" /translation="MTHQIVTTQYGKVKGTTENGVHKWKGIPYAKPPVGQWRFKAPEP PEVWEDVLDATAYGSICPQPSDLLSLSYTELPRQSEDCLYVNVFAPDTPSKNLPVMVW IHGGAFYLGAGSEPLYDGSKLAAQGEVIVVTLNYRLGPFGFLHLSSFNEAYSDNLGLL DQAAALKWVRENISAFGGDPDNVTVFGESAGGMSIAALLAMPAAKGLFQKAIMESGAS RTMTKEQAASTSAAFLQVLGINEGQLDKLHTVSAEDLLKAADQLRIAEKENIFQLFFQ PALDPKTLPEEPEKAIAEGAASGIPLLIGTTRDEGYLFFTPDSDVHSQETLDAALEYL LGKPLAEKVADLYPRSLESQIHMMTDLLFWRPAVAYASAQSHYAPVWMYRFDWHPKKP PYNKAFHALELPFVFGNLDGLERMAKAEITDEVKQLSHTIQSAWITFAKTGNPSTEAV NWPAYHEETRETLILDSEITIENDPESEKRQKLFPSKGE*" /label="pnbA CDS" gene 3045544..3047013 /gene="pnbA" /locus_tag="BSU_34390" /old_locus_tag="BSU34390" /label="pnbA gene" downshifts 3046990 /Source="Nicolas_upshifts" /id="D1780" /incds=0 /nref=4 /ntot=150 /MaxReadThrough="3.66738" /MaxDrop="2.70933" /score="-9.70074934" /energy="-12.2" /TU="U2703" /idTUdmin="U2703" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" CDS 3047016..3047207 /locus_tag="BSU_34399" /old_locus_tag="BSU34399" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514003.1" /translation="MGKTGYIGAAIVVAACIIILSAVVCLRDTVYYQPMRWTGIILFF AGIVMVPAYSAKRKPGKEK*" /label="hypothetical protein CDS" gene 3047016..3047207 /locus_tag="BSU_34399" /old_locus_tag="BSU34399" /label="gene" downshifts 3047186 /Source="Nicolas_upshifts" /id="D1781" /incds=0 /nref=24 /ntot=181 /MaxReadThrough="-0.096" /MaxDrop="4.20686" /score="34.8993337" /energy="-22.3" /TU="NA" /idTUdmin="U2703" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(3047234..3047719) /gene="padC" /locus_tag="BSU_34400" /old_locus_tag="BSU34400" /EC_number="4.1.1.102" /EC_number="4.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9546183, 12903944, 17295427, 18326577, 21685295, 26658822" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9546183, 12903944, 17295427, 18326577, 21685295, 26658822; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase" /protein_id="NP_391320.1" /db_xref="EnsemblGenomes-Gn:BSU34400" /db_xref="EnsemblGenomes-Tr:CAB15445" /db_xref="GOA:O07006" /db_xref="InterPro:IPR008729" /db_xref="InterPro:IPR012674" /db_xref="PDB:2P8G" /db_xref="PDB:4ALB" /db_xref="SubtiList:BG12433" /db_xref="UniProtKB/Swiss-Prot:O07006" /translation="MENFIGSHMIYTYENGWEYEIYIKNDHTIDYRIHSGMVAGRWVR DQEVNIVKLTEGVYKVSWTEPTGTDVSLNFMPNEKRMHGIIFFPKWVHEHPEITVCYQ NDHIDLMKESREKYETYPKYVVPEFAEITFLKNEGVDNEEVISKAPYEGMTDDIRAGR L*" /label="padC CDS" gene complement(3047234..3047719) /gene="padC" /locus_tag="BSU_34400" /old_locus_tag="BSU34400" /label="padC gene" CDS complement(3047742..3048053) /gene="yveG" /locus_tag="BSU_34410" /old_locus_tag="BSU34410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /db_xref="EnsemblGenomes-Gn:BSU34410" /db_xref="EnsemblGenomes-Tr:CAB15446" /db_xref="GOA:O07005" /db_xref="InterPro:IPR011250" /db_xref="InterPro:IPR020915" /db_xref="PSEUDO:CAB15446.2" /db_xref="SubtiList:BG12432" /db_xref="UniProtKB/Swiss-Prot:O07005" /translation="MPGGADSQMIRANGRTDLSARYVIETADHELIYIENNGIRQVSK PFRKQAAAGEIIEPEHVYFRTVPTFETGSEVYQWLHDRLFIGSAERTPDYVLLDIYEV Q*" /label="yveG CDS" gene complement(3047742..3048053) /gene="yveG" /locus_tag="BSU_34410" /old_locus_tag="BSU34410" /pseudo /label="yveG gene" CDS complement(3048105..3048197) /gene="yveF" /locus_tag="BSU_34420" /old_locus_tag="BSU34420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="EnsemblGenomes-Gn:BSU34420" /db_xref="EnsemblGenomes-Tr:CAB15447" /db_xref="PSEUDO:CAB15447.1" /db_xref="SubtiList:BG12431" /db_xref="UniProtKB/Swiss-Prot:O07004" /translation="MKKPVLKPFASLEIKVDPPITIGETSLGLR*" /label="yveF CDS" gene complement(3048105..3048197) /gene="yveF" /locus_tag="BSU_34420" /old_locus_tag="BSU34420" /pseudo /label="yveF gene" promotor_-10 complement(3048237..3048256) /Source="Nicolas_upshift_promotors" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3048254) /Source="Nicolas_upshifts" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3048270..3048277) /Source="Nicolas_upshift_promotors" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3048328..3049011) /gene="racX" /locus_tag="BSU_34430" /old_locus_tag="BSU34430" /EC_number="5.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9987136, 19063962, 2054383, 28894939" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 19063962, 2054383, 28894939; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous aminoacid racemase (prefers arginine, lysine and ornithine)" /protein_id="NP_391323.1" /db_xref="EnsemblGenomes-Gn:BSU34430" /db_xref="EnsemblGenomes-Tr:CAB15448" /db_xref="GOA:P32960" /db_xref="InterPro:IPR001920" /db_xref="InterPro:IPR004380" /db_xref="InterPro:IPR015942" /db_xref="InterPro:IPR018187" /db_xref="InterPro:IPR033134" /db_xref="SubtiList:BG10391" /db_xref="UniProtKB/Swiss-Prot:P32960" /translation="MIGILAGMGPKSTSPFIDKVIDYCQKLYGASNDIDYPHMMIYSC PTPFYADRPIDHDEMKKAIIDGAVKLEKTGVDFIALPCNTAHVYYEEIQQALSVPMLH IVEETIKEIPHPAKKAVVLGTEPTIQSAIYQKVLKGNGQEVIHKDHWQQAVNQLIAAI KQPNHMQHTQALWQTLYEEISQHADIIISACTDLNAVLDHIQSEIPIIDSSACLAKST VSTYLAYQS*" /label="racX CDS" gene complement(3048328..3049011) /gene="racX" /locus_tag="BSU_34430" /old_locus_tag="BSU34430" /label="racX gene" downshifts complement(3048346) /Source="Nicolas_upshifts" /id="D1782" /incds=0 /nref=122 /ntot=223 /MaxReadThrough="3.49026" /MaxDrop="5.32077" /score="5.15607483" /energy="-9.3" /TU="U2705" /idTUdmin="U2704" /TUdmin="-708" /isTUend="FALSE" /label="downshifts" CDS complement(3049027..3050382) /gene="pbpE" /locus_tag="BSU_34440" /old_locus_tag="BSU34440" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7592498, 9987136, 12533473, 14679248, 19063962" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592498, 9987136, 12533473, 14679248, 19063962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 4*" /protein_id="NP_391324.1" /db_xref="EnsemblGenomes-Gn:BSU34440" /db_xref="EnsemblGenomes-Tr:CAB15449" /db_xref="GOA:P32959" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR021860" /db_xref="SubtiList:BG10390" /db_xref="UniProtKB/Swiss-Prot:P32959" /translation="MKQNKRKHLQTLFETLGEKHQFNGTVLAAEGGDILYHHSFGYAE MTEKRPLKTNSLFELASLSKPFTALGIILLEEKGILGYEDKVDRWLPGFPYQGVTIRH LLNHTSGLPDYMGWFFANWDSHKIAVNQDIVDMLMNEGLSGYFEPNEGWMYSNTGYVL LAVIIEKASGMSYADFIKTSIFLPAGMNETRVYNRRLSPERIDHYAYGYVYDVHSETY VLPDELEETNYVVYLDGIQGDGTVNSVTSDLFRFDQALYQDDFISKASKESAFSPVRL NNGETIDYGFGWVLQNSPEKGRIVSHSGGWPGYSTMMIRYIDHRKTLIYLSNKEEDTE YEQAILKAAEHILFGQPYDVPERPADKKKKAIDTAIYSRYVGSYLLQDGTAAQVTTEN ERLYLEIAGQLRLELFPSSETRFFLRALSVEVEFTLGEDAAKSFILYEDGSEEEAVRT K*" /label="pbpE CDS" gene complement(3049027..3050382) /gene="pbpE" /locus_tag="BSU_34440" /old_locus_tag="BSU34440" /label="pbpE gene" promotor_-10 complement(3050394..3050409) /Source="Nicolas_upshift_promotors" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3050410) /Source="Nicolas_upshifts" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3050421..3050430) /Source="Nicolas_upshift_promotors" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3050684..3050691 /Source="Nicolas_upshift_promotors" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3050705..3050724 /Source="Nicolas_upshift_promotors" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3050708 /Source="Nicolas_upshifts" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="upshifts" S_feature 3050730..3050920 /Source="Nicolas_S_feature" /locus_tag="new_3535821_3536011" /HighExp="G150, G180, G135, LBGexp, Mt0, Lbexp, LBGtran, dia0, GM 150, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.219024" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1314" CDS 3050921..3052342 /gene="sacB" /locus_tag="BSU_34450" /old_locus_tag="BSU34450" /EC_number="2.4.1.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1400159, 11200435, 11320136, 11739774, 17704766, 15528654, 26600431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1400159, 11200435, 11320136, 11739774, 17704766, 15528654, 26600431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="levansucrase; levanase (moonlighting)" /protein_id="NP_391325.1" /db_xref="EnsemblGenomes-Gn:BSU34450" /db_xref="EnsemblGenomes-Tr:CAB15450" /db_xref="GOA:P05655" /db_xref="InterPro:IPR003469" /db_xref="InterPro:IPR023296" /db_xref="PDB:1OYG" /db_xref="PDB:1PT2" /db_xref="PDB:2VDT" /db_xref="PDB:3BYJ" /db_xref="PDB:3BYK" /db_xref="PDB:3BYL" /db_xref="PDB:3BYN" /db_xref="SubtiList:BG10388" /db_xref="UniProtKB/Swiss-Prot:P05655" /translation="MNIKKFAKQATVLTFTTALLAGGATQAFAKETNQKPYKETYGIS HITRHDMLQIPEQQKNEKYQVPEFDSSTIKNISSAKGLDVWDSWPLQNADGTVANYHG YHIVFALAGDPKNADDTSIYMFYQKVGETSIDSWKNAGRVFKDSDKFDANDSILKDQT QEWSGSATFTSDGKIRLFYTDFSGKHYGKQTLTTAQVNVSASDSSLNINGVEDYKSIF DGDGKTYQNVQQFIDEGNYSSGDNHTLRDPHYVEDKGHKYLVFEANTGTEDGYQGEES LFNKAYYGKSTSFFRQESQKLLQSDKKRTAELANGALGMIELNDDYTLKKVMKPLIAS NTVTDEIERANVFKMNGKWYLFTDSRGSKMTIDGITSNDIYMLGYVSNSLTGPYKPLN KTGLVLKMDLDPNDVTFTYSHFAVPQAKGNNVVITSYMTNRGFYADKQSTFAPSFLLN IKGKKTSVVKDSILEQGQLTVNK*" /label="sacB CDS" gene 3050921..3052342 /gene="sacB" /locus_tag="BSU_34450" /old_locus_tag="BSU34450" /label="sacB gene" downshifts 3052336 /Source="Nicolas_upshifts" /id="D1783" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="2.33324" /MaxDrop="3.39023" /score="9.57663013" /energy="-7.7" /TU="NA" /idTUdmin="U2706" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3052416..3053966 /gene="levB" /locus_tag="BSU_34460" /old_locus_tag="BSU34460" /EC_number="3.2.1.64" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11739774, 15528654, 26773563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11739774, 15528654, 26773563; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endolevanase, selectively cleaves the (beta-2,6)fructosyl bonds" /protein_id="NP_391326.1" /db_xref="EnsemblGenomes-Gn:BSU34460" /db_xref="EnsemblGenomes-Tr:CAB15451" /db_xref="GOA:O07003" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR023296" /db_xref="SubtiList:BG12430" /db_xref="UniProtKB/Swiss-Prot:O07003" /translation="MNYIKAGKWLTVFLTFLGILLFIDLFPKEEHDQKTKSKQKPDYR AAYHFTTPDKWKNDPQKPIYFDGKYHYFYLYNRDYPKGNGTEWRHAVSEDLVHWTDEG VAIPKYTNPDGDIWTGSVVVDKENTAGFGKNALVAIVTQPSAKDKKQEQYLWYSTDKG KSFKFYSGNPVMPNPGTDDFRDPKVIWDDQDNKWVMVMAEGSKIGFYESDNLKDWHYT SGFFPEQAGMVECPDLYMMRASDGTNKWVLGASANGKPWGKPNTYAYWTGSFDGKEFK ADQTEAQWLDYGFDWYGGVTFEDSKSTDPLEKRYALAWMNNWDYANNTPTMKNGFNGT DSVIRELRLKEQDGTYSLVSQPIEALEQLTVSTDEIEDQDVNGSKTLSITGDTYQLDT DLSWSELKNAGVRLRESEDQKRHIDVGIFAEGGYAYVNRAATNQPDKSNTYVESKAPY DVNKRKVHLKILVDKTTIEVFVGDGKTVFSNEVFPKPEDKGITLYSDGGTASFKNITV KHFDSIHE*" /label="levB CDS" gene 3052416..3053966 /gene="levB" /locus_tag="BSU_34460" /old_locus_tag="BSU34460" /label="levB gene" promotor_-35 3054010..3054016 /Source="Nicolas_upshift_promotors" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3054030..3054041 /Source="Nicolas_upshift_promotors" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3054030 /Source="Nicolas_upshifts" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="upshifts" CDS 3054074..3055636 /gene="aspP" /locus_tag="BSU_34470" /old_locus_tag="BSU34470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12730183, 15528654, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12730183, 15528654, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-aspartate/L-glutamate / proton permease" /protein_id="NP_391327.1" /db_xref="EnsemblGenomes-Gn:BSU34470" /db_xref="EnsemblGenomes-Tr:CAB15452" /db_xref="GOA:O07002" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12429" /db_xref="UniProtKB/Swiss-Prot:O07002" /translation="MSKQGNFQKSMSLFDLILIGMGAIFGSAWLFAVSNVASKAGPSG AFSWILGGAIILLIGLVYAELGAALPRTGGIIRYPVYSHGHLVGYLISFVTIVAYTSL ISIEVTAVRQYVAYWFPGLTIKGSDSPTISGWILQFALLCLFFLLNYWSVKTFAKANF IISIFKYIVPITIIIVLIFHFQPENLSVQGFAPFGFTGIQAAISTGGVMFAYLGLHPI VSVAGEVQNPKRNIPIALIICIIVSTIIYTVLQVTFIGAIPTETLKHGWPAIGREFSL PFKDIAVMLGLGWLATLVILDAILSPGGNGNIFMNTTSRLVYAWARNGTLFGIFSKVN KDTGTPRASLWLSFALSIFWTLPFPSWNALVNVCSVALILSYAIAPISSAALRVNAKD LNRPFYLKGMSIIGPLSFIFTAFIVYWSGWKTVSWLLGSQLVMFLIYLCFSKYTPKED VSLAQQLKSAWWLIGFYIMMLIFSYIGSFGHGLGIISNPVDLILVAIGSLAIYYWAKY TGLPKAAIDYDK*" /label="aspP CDS" gene 3054074..3055636 /gene="aspP" /locus_tag="BSU_34470" /old_locus_tag="BSU34470" /label="aspP gene" downshifts 3055614 /Source="Nicolas_upshifts" /id="D1784" /incds=0 /nref=12 /ntot=29 /MaxReadThrough="1.71122" /MaxDrop="3.47798" /score="-0.444529447" /energy="-11.7" /TU="NA" /idTUdmin="U2707" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3055626..3056315 /gene="yvdT" /locus_tag="BSU_34480" /old_locus_tag="BSU34480" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_391328.2" /db_xref="EnsemblGenomes-Gn:BSU34480" /db_xref="EnsemblGenomes-Tr:CAB15453" /db_xref="GOA:O07001" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:2F07" /db_xref="SubtiList:BG12428" /db_xref="UniProtKB/Swiss-Prot:O07001" /translation="MINKEARGFLASLFFTNKHTRDKMNESQSLLEVFLMPKQTSGKY EKILQAAIEVISEKGLDKASISDIVKKAGTAQGTFYLYFSSKNALIPAIAENLLTHTL DQIKGRLHGDEDFWTVLDILIDETFLITERHKDIIVLCYSGLAIDHSMEKWETIYQPY YSWLEKIINKAIANHEVTEGINSKWTARTIINLVENTAERFYIGFEQDENVEVYKKEI FTFLKRSLGTA*" /label="yvdT CDS" gene 3055626..3056315 /gene="yvdT" /locus_tag="BSU_34480" /old_locus_tag="BSU34480" /label="yvdT gene" promotor_-35 3055665..3055672 /Source="Nicolas_upshift_promotors" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3055686..3055705 /Source="Nicolas_upshift_promotors" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3055695 /Source="Nicolas_upshifts" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="upshifts" downshifts 3056296 /Source="Nicolas_upshifts" /id="D1785" /incds=0 /nref=189 /ntot=242 /MaxReadThrough="4.85194" /MaxDrop="4.84113" /score="-0.444529447" /energy="-11.7" /TU="U2708" /idTUdmin="U2707" /TUdmin=682 /isTUend="FALSE" /label="downshifts" downshifts complement(3056394) /Source="Nicolas_upshifts" /id="D1786" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="0.8852" /MaxDrop="3.45447" /score="0.398849185" /energy="-11.7" /TU="NA" /idTUdmin="U2709" /TUdmin=704 /isTUend="FALSE" /label="downshifts" CDS 3056397..3056732 /gene="psmA" /locus_tag="BSU_34490" /old_locus_tag="BSU34490" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22978536; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sodium / proton antiporter subunit A" /protein_id="NP_391329.1" /db_xref="EnsemblGenomes-Gn:BSU34490" /db_xref="EnsemblGenomes-Tr:CAB15454" /db_xref="GOA:O32262" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12427" /db_xref="UniProtKB/Swiss-Prot:O32262" /translation="MNWVLVFIAGLLEVVWASSLKHADSLLDWIIIFILIAVSFILLI RSYQKIPMAAAYTVFVGIGTVGTYLTGIVLGESFSAAQMFFLALLLAGILGMKLFTKE SKSQPGGEK*" /label="psmA CDS" gene 3056397..3056732 /gene="psmA" /locus_tag="BSU_34490" /old_locus_tag="BSU34490" /label="psmA gene" CDS 3056732..3057052 /gene="psmB" /locus_tag="BSU_34500" /old_locus_tag="BSU34500" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11160890, 22978536; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium-proton two component antiporter subunit" /protein_id="NP_391330.1" /db_xref="EnsemblGenomes-Gn:BSU34500" /db_xref="EnsemblGenomes-Tr:CAB15455" /db_xref="GOA:O06999" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12426" /db_xref="UniProtKB/Swiss-Prot:O06999" /translation="MAWFLLVIAGIEEIIAAIAMKYIDGTRKKWPIIVMTVGFGLSFY CLSQAMIVLPAGVAYAVWTGIGSIGVSAVGLIWFKERFQLSQVISLCLILAGVIGLRL TSSS*" /label="psmB CDS" gene 3056732..3057052 /gene="psmB" /locus_tag="BSU_34500" /old_locus_tag="BSU34500" /label="psmB gene" S_feature 3057053..3057243 /Source="Nicolas_S_feature" /locus_tag="new_3542144_3542334" /HighExp="Sw, BC, BI, Lbstat, M0t90, Lbtran, M40t90, H2O2, S8, Paraq" /AntisenseName="yvdQ" /AntisenseCor="3.5547360410813897E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1315" CDS complement(3057088..3057600) /gene="yvdQ" /locus_tag="BSU_34510" /old_locus_tag="BSU34510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391331.1" /db_xref="EnsemblGenomes-Gn:BSU34510" /db_xref="EnsemblGenomes-Tr:CAB15456" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR021617" /db_xref="SubtiList:BG12425" /db_xref="UniProtKB/Swiss-Prot:O06998" /translation="MGILSGNPQDEPMHYGEVFGLWSYVMAGNKMVGNYQMLLNHVGD DDLKKLLRESIEKCQDEIKQVSTILKENGVALPPASPEPPTADLNDIPPGARFLDPDV AASAAAENAAGLVTCSKMMGQSIREDIAMMFGQFHMSKAATGAKYLRLLKNKGWLIPP PLHLQKHHEA*" /label="yvdQ CDS" gene complement(3057088..3057600) /gene="yvdQ" /locus_tag="BSU_34510" /old_locus_tag="BSU34510" /label="yvdQ gene" downshifts 3057220 /Source="Nicolas_upshifts" /id="D1787" /incds=1 /nref=6 /ntot=39 /MaxReadThrough="1.61612" /MaxDrop="4.65362" /score="0.608596632" /energy="-14.2" /TU="NA" /idTUdmin="U2708" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3057636..3057647) /Source="Nicolas_upshift_promotors" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3057642) /Source="Nicolas_upshifts" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3057662..3057668) /Source="Nicolas_upshift_promotors" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3057715..3057851) /Source="Nicolas_S_feature" /locus_tag="new_3542806_3542942_c" /HighExp="BT, S7, S8, S6, B36, G/S, S5, Pyr, G135, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1316" downshifts complement(3057758) /Source="Nicolas_upshifts" /id="D1788" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="3.38169" /MaxDrop="2.9968" /score="15.2862513" /energy="-10.3" /TU="U2710" /idTUdmin="U2709" /TUdmin="-660" /isTUend="FALSE" /label="downshifts" CDS complement(3057852..3059195) /gene="cotNP" /locus_tag="BSU_34520" /old_locus_tag="BSU34520" /EC_number="1.-.-.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12562816" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat protein; putative oxidoreductase" /protein_id="NP_391332.1" /db_xref="EnsemblGenomes-Gn:BSU34520" /db_xref="EnsemblGenomes-Tr:CAB15457" /db_xref="GOA:O06997" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR012951" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12424" /db_xref="UniProtKB/Swiss-Prot:O06997" /translation="MGSTQLTGRVIFKGDPGYTEAIKNWNPYVDVYPLVFVFAQNSYD VSNAIKWARENKVPLRVRSGRHALDKNLSVVSGGIVIDVSDMNKVFLDEENAIATVQT GIPVGPLVKGLARDGFMAPFGDSPTVGIGGITMGGGFGVLSRSIGLISDNLLALKTVD AKGRIIHADQSHNEDLLWASRGGGGGNFGYNTQYTFKVHRAPKTATVFNIIWPWEQLE TVFKAWQKWAPFVDERLGCYLEIYSKINGLCHAEGIFLGSKTELIRLLKPLLHAGTPT EADIKTLYYPDAIDFLDPDEPIPGRNDQSVKFSSAWGHDFWSDEPISIMRKFLEDATG TEANFFFINWGGAISRVPKDETAFFWRHPLFYTEWTASWKNKSQEDSNLASVERVRQL MQPYVAGSYVNVPDQNIENFGKEYYGANFARLREIKAKYDPENVFRFPQSIPPSR*" /label="cotNP CDS" gene complement(3057852..3059195) /gene="cotNP" /locus_tag="BSU_34520" /old_locus_tag="BSU34520" /label="cotNP gene" promotor_-10 complement(3059224..3059243) /Source="Nicolas_upshift_promotors" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3059232) /Source="Nicolas_upshifts" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3059256..3059265) /Source="Nicolas_upshift_promotors" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3059257..3059262 /Source="Nicolas_upshift_promotors" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3059278..3059296 /Source="Nicolas_upshift_promotors" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3059281 /Source="Nicolas_upshifts" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3059490..3059499 /Source="Nicolas_upshift_promotors" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3059508 /Source="Nicolas_upshifts" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3059513..3059532 /Source="Nicolas_upshift_promotors" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3059551..3060513 /gene="cotR" /locus_tag="BSU_34530" /old_locus_tag="BSU34530" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 20378985" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 20378985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat lipolytic enzyme" /protein_id="NP_391333.1" /db_xref="EnsemblGenomes-Gn:BSU34530" /db_xref="EnsemblGenomes-Tr:CAB15458" /db_xref="GOA:O06996" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG12423" /db_xref="UniProtKB/Swiss-Prot:O06996" /translation="MAKYRIMTFDGGGTLGALSLQLLNRLARQNPKLISRTHVFSGNS IGSFTALALASGRSPRETLQYFEDEILPAFSISRPGGPVFNQQLPYSGFIKAVRNFFP ADLQLIDLRKRIVVPSFKLYSQKLDRWTPVLFHNFPGSPYLNEKVSDVILRSSGAPAT QRAYQNYVDGYVVATNPSTASIAFAVGKANVPLDQIAVLSIGTGEAPTRLRRDTRGWG MVSADNIRPENLKNLPPNWGVLLDRSPNEPLLPFLQMIAGGNGYYESMVSANLLGDRF FRLDPRIPNFSKTDPAVVPAVIEIANKTNLQPANQFIEKNWGSK*" /label="cotR CDS" gene 3059551..3060513 /gene="cotR" /locus_tag="BSU_34530" /old_locus_tag="BSU34530" /label="cotR gene" S_feature 3060514..3060767 /Source="Nicolas_S_feature" /locus_tag="new_3545605_3545858" /HighExp="BT, S8, S7, B36, S6, Pyr, G/S, S3, C30, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1317" downshifts complement(3060794) /Source="Nicolas_upshifts" /id="D1789" /incds=0 /nref=190 /ntot=241 /MaxReadThrough="3.19421" /MaxDrop="5.60739" /score="16.7489574" /energy="-13.2" /TU="U2713" /idTUdmin="U2713" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" tRNA complement(3060798..3060873) /gene="trnQ-Arg" /locus_tag="BSU_tRNA_81" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="arginine transfer RNA (CCG); Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27749819; Product type n : RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnQ-Arg tRNA" gene complement(3060798..3060873) /gene="trnQ-Arg" /locus_tag="BSU_tRNA_81" /label="trnQ-Arg gene" promotor_-10 complement(3060900..3060919) /Source="Nicolas_upshift_promotors" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3060921) /Source="Nicolas_upshifts" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3060935..3060938) /Source="Nicolas_upshift_promotors" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3061004..3061010 /Source="Nicolas_upshift_promotors" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3061020..3061095 /Source="Nicolas_S_feature" /locus_tag="new_3546111_3546186" /HighExp="Salt, S3, S4, Etha, S5, LoTm, Gly, M9-stat, BT, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1318" upshifts 3061020 /Source="Nicolas_upshifts" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3061025..3061044 /Source="Nicolas_upshift_promotors" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3061072..3061079 /Source="Nicolas_upshift_promotors" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3061093..3061112 /Source="Nicolas_upshift_promotors" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3061097 /Source="Nicolas_upshifts" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="upshifts" CDS 3061143..3061736 /gene="clpP" /locus_tag="BSU_34540" /old_locus_tag="BSU34540" /EC_number="3.4.21.92" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11722737, 11807061, 15317791, 16163393, 21546913, 21969594, 22226636, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11722737, 11807061, 15317791, 16163393, 21546913, 21969594, 22226636, 27749819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent Clp protease proteolytic subunit; Maxwell's demon" /protein_id="NP_391334.1" /db_xref="EnsemblGenomes-Gn:BSU34540" /db_xref="EnsemblGenomes-Tr:CAB15459" /db_xref="GOA:P80244" /db_xref="InterPro:IPR001907" /db_xref="InterPro:IPR018215" /db_xref="InterPro:IPR023562" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR033135" /db_xref="PDB:3KTG" /db_xref="PDB:3KTH" /db_xref="PDB:3KTI" /db_xref="PDB:3KTJ" /db_xref="PDB:3KTK" /db_xref="PDB:3TT6" /db_xref="PDB:3TT7" /db_xref="SubtiList:BG19016" /db_xref="UniProtKB/Swiss-Prot:P80244" /translation="MNLIPTVIEQTNRGERAYDIYSRLLKDRIIMLGSAIDDNVANSI VSQLLFLAAEDPEKEISLYINSPGGSITAGMAIYDTMQFIKPKVSTICIGMAASMGAF LLAAGEKGKRYALPNSEVMIHQPLGGAQGQATEIEIAAKRILLLRDKLNKVLAERTGQ PLEVIERDTDRDNFKSAEEALEYGLIDKILTHTEDKK*" /label="clpP CDS" gene 3061143..3061736 /gene="clpP" /locus_tag="BSU_34540" /old_locus_tag="BSU34540" /label="clpP gene" downshifts 3061725 /Source="Nicolas_upshifts" /id="D1790" /incds=0 /nref=292 /ntot=300 /MaxReadThrough="4.45406" /MaxDrop="8.24306" /score="30.2626808" /energy="-14.6" /TU="U2714" /idTUdmin="U2715" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" S_feature 3061770..3062168 /Source="Nicolas_S_feature" /locus_tag="new_3546861_3547259" /HighExp="Etha, dia15, Heat, LoTm, M9-stat, Gly, dia5, Diami, S8, H2O2" /AntisenseName="pgcM" /AntisenseCor="0.13310786898312499" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1319" CDS complement(3061782..3062462) /gene="mdxM" /locus_tag="BSU_34550" /old_locus_tag="BSU34550" /EC_number="2.7.1.41" /EC_number="5.4.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:4275311, 11081794, 15996095" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4275311, 11081794, 15996095; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional beta-phosphoglucomutase / glucose-1-phosphate phosphodismutase" /protein_id="NP_391335.1" /db_xref="EnsemblGenomes-Gn:BSU34550" /db_xref="EnsemblGenomes-Tr:CAB15460" /db_xref="GOA:O06995" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR010972" /db_xref="InterPro:IPR010976" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3NAS" /db_xref="SubtiList:BG12422" /db_xref="UniProtKB/Swiss-Prot:O06995" /translation="MKAVIFDLDGVITDTAEYHFLAWKHIAEQIDIPFDRDMNERLKG ISREESLESILIFGGAETKYTNAEKQELMHRKNRDYQMLISKLTPEDLLPGIGRLLCQ LKNENIKIGLASSSRNAPKILRRLAIIDDFHAIVDPTTLAKGKPDPDIFLTAAAMLDV SPADCAAIEDAEAGISAIKSAGMFAVGVGQGQPMLGADLVVRQTSDLTLELLHEEWEQ YRIRESIP*" /label="mdxM CDS" gene complement(3061782..3062462) /gene="mdxM" /locus_tag="BSU_34550" /old_locus_tag="BSU34550" /label="mdxM gene" downshifts complement(3061806) /Source="Nicolas_upshifts" /id="D1791" /incds=0 /nref=2 /ntot=36 /MaxReadThrough="3.4944" /MaxDrop="3.50516" /score="-9.43329271" /energy="-14.6" /TU="U2718" /idTUdmin="U2718" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" CDS complement(3062459..3064144) /gene="mdxL" /locus_tag="BSU_34560" /old_locus_tag="BSU34560" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9573215, 10229946, 1670768" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9573215, 10229946, 1670768; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligo-1,4-1,6-alpha-glucosidase (sucrase-maltase-isomaltase)" /protein_id="NP_391336.1" /db_xref="EnsemblGenomes-Gn:BSU34560" /db_xref="EnsemblGenomes-Tr:CAB15461" /db_xref="GOA:O06994" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="PDB:4M56" /db_xref="PDB:4M8U" /db_xref="PDB:4MAZ" /db_xref="PDB:4MB1" /db_xref="SubtiList:BG12421" /db_xref="UniProtKB/Swiss-Prot:O06994" /translation="MSEWWKEAVVYQIYPRSFYDANGDGFGDLQGVIQKLDYIKNLGA DVIWLSPVFDSPQDDNGYDISDYKNMYEKFGTNEDMFQLIDEVHKRGMKIVMDLVVNH TSDEHAWFAESRKSKDNPYRDYYLWKDPKPDGSEPNNWGSIFSGSAWTYDEGTGQYYL HYFSKKQPDLNWENEAVRREVYDVMRFWMDRGVDGWRMDVIGSISKYTDFPDYETDHS RSYIVGRYHSNGPRLHEFIQEMNREVLSHYDCMTVGEANGSDIEEAKKYTDASRQELN MIFTFEHMDIDKEQNSPNGKWQIKPFDLIALKKTMTRWQTGLMNVGWNTLYFENHDQP RVISRWGNDRKLRKECAKAFATVLHGMKGTPFIYQGEEIGMVNSDMPLEMYDDLEIKN AYRELVVENKTMSEKEFVKAVMIKGRDHARTPMQWDAGKHAGFTAGDPWIPVNSRYQD INVKESLEDQDSIFFYYQKLIQLRKQYKIMIYGDYQLLQENDPQVFSYLREYRGEKLL VVVNLSEEKALFEAPPELIHERWKVLISNYPQERADLKSISLKPYEAVMGISI*" /label="mdxL CDS" gene complement(3062459..3064144) /gene="mdxL" /locus_tag="BSU_34560" /old_locus_tag="BSU34560" /label="mdxL gene" CDS complement(3064137..3066410) /gene="mdxK" /locus_tag="BSU_34570" /old_locus_tag="BSU34570" /EC_number="2.4.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16707683, 28527120" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683, 28527120; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maltose phosphorylase" /protein_id="NP_391337.1" /db_xref="EnsemblGenomes-Gn:BSU34570" /db_xref="EnsemblGenomes-Tr:CAB15462" /db_xref="GOA:O06993" /db_xref="InterPro:IPR005194" /db_xref="InterPro:IPR005195" /db_xref="InterPro:IPR005196" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR011013" /db_xref="InterPro:IPR017045" /db_xref="SubtiList:BG12420" /db_xref="UniProtKB/Swiss-Prot:O06993" /translation="MINQRLFEIDEWKIKTNTFNKEHTRLLESLTSLANGYMGVRGNF EEGYSGDSHQGTYIAGVWFPDKTRVGWWKNGYPEYFGKVINAMNFMGIGLYVDGEKID LHQNPIELFEVELNMKEGILRRSAVVRIQDKTVRIRSERFLSLAVKELCAIHYEAECL TGDAVITLVPYLDGNVANEDSNYQEQFWQEEAKGADSHSGHLAAKTIENPFGTPRFTV LAAMANETEGFVHESFKTTEMYVENRYSYQTKASLKKFVIVTTSRDFREEELLSKAKE LLADVVENGYEDAKRRHTDRWKERWAKADIEIKGDEELQQGIRYNIFQLFSTYYGGDA RLNIGPKGFTGEKYGGAAYWDTEAYAVPMYLATAEPEVTKNLLLYRYHQLEAAKRNAA KLGMKGALYPMVTFTGDECHNEWEITFEEIHRNGAICYAIYNYINYTGDRNYMEEYGI DVLVAVSRFWADRVHFSKRKNKYMIHGVTGPNEYENNVNNNWYTNVIAAWTLEYTLQS LESISAEKRRHLDVQEVELEVWREIIQHMYYPFSEELQIFVQHDTFLDKDLQTVDELD PAERPLYQNWSWDKILRSNFIKQADVLQGIYLFNDRFTMEEKRRNFEFYEPMTVHESS LSPSVHAILAAELKLEKKALELYKRTARLDLDNYNHDTEEGLHITSMTGSWLAIVHGF AGMRTANETLSFAPFLPKEWDEYSFNINYRNRLINVTVDEKRVIFELVKGEPLHMNVY EEPVVLQGRCERRTPNE*" /label="mdxK CDS" gene complement(3064137..3066410) /gene="mdxK" /locus_tag="BSU_34570" /old_locus_tag="BSU34570" /label="mdxK gene" CDS complement(3066388..3067272) /gene="mdxJ" /locus_tag="BSU_34580" /old_locus_tag="BSU34580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16707683, 16850406, 20436965; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative component of maltodextrin transporter" /protein_id="NP_391338.1" /db_xref="EnsemblGenomes-Gn:BSU34580" /db_xref="EnsemblGenomes-Tr:CAB15463" /db_xref="GOA:O06992" /db_xref="InterPro:IPR009574" /db_xref="SubtiList:BG12419" /db_xref="UniProtKB/Swiss-Prot:O06992" /translation="MKNLENKSFIIRCLKAAASPSGVCRYGNTFSWLQLSFLFLFLTA CLMAPLAVSFVKMDRFSVSSFMPSAIQGVNDQFADQLQGFQIRNGKLTGGKSSERIED GQNVMAVDMKHEYETSGENGRLKVTGFENAIIFQPDQLVITDQNETGFSVGYAKMDVK LEKPNVHDVEVLIDTLWLAQYKPMIMMLAYTVVSMIQLLLTFVLAGGLWITKISNMVS IASFKEAASIAICASALPAFAAAAIGMVHFDLITVLMIHSCGVTLMISFAFRYLTKTR RDNGNLHSGGNDDKSAVI*" /label="mdxJ CDS" gene complement(3066388..3067272) /gene="mdxJ" /locus_tag="BSU_34580" /old_locus_tag="BSU34580" /label="mdxJ gene" CDS complement(3067278..3068114) /gene="mdxG" /locus_tag="BSU_34590" /old_locus_tag="BSU34590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="maltodextrin ABC transporter (permease)" /protein_id="NP_391339.1" /db_xref="EnsemblGenomes-Gn:BSU34590" /db_xref="EnsemblGenomes-Tr:CAB15464" /db_xref="GOA:O06991" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12418" /db_xref="UniProtKB/Swiss-Prot:O06991" /translation="MNASTARMLNKICTYLFLTLLSIVIIYPLLITASSAFRVGNSAA FQLDFSGSWTLDHFKRLFDETLYLNWYSNTLVIALSVMVLQVTIVTLAGYSYSRYRFA GRKKSLIFFLIIQMVPTMAALTAFYVLAMLIGALDQYWFLTAIYIGGGIPMNTWLMKG YFDTVPREIDEAARIDGAGHLRIFASIVLPLVKPMLAVQALWAFMAPFGDYLLTKFLL RSPERLTIAVGLQSFISNPQQQKVALFAAGAILAALPICVLFFFLQKNFVSGLTAGGT KG*" /label="mdxG CDS" gene complement(3067278..3068114) /gene="mdxG" /locus_tag="BSU_34590" /old_locus_tag="BSU34590" /label="mdxG gene" CDS complement(3068115..3069422) /gene="mdxF" /locus_tag="BSU_34600" /old_locus_tag="BSU34600" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="maltodextrin ABC transport system (permease)" /protein_id="NP_391340.1" /db_xref="EnsemblGenomes-Gn:BSU34600" /db_xref="EnsemblGenomes-Tr:CAB15465" /db_xref="GOA:O06990" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12417" /db_xref="UniProtKB/Swiss-Prot:O06990" /translation="MNKHHTLTKQKRKAGLLSIIPGLGQIANQQLSKGLLFLAITGLF AFELCVFGIQALTGLMTLGSVPGEDHSLFMLIEGTLQLIVTMIFLMFYIFNIHDSRKT AAMKAAGLEVNTTAKDMICHAGDKGFPYLFTLPAYIMMVFVIIFPVLVTLFVALTNYD FYHIPPNRLIDWVGFKNFLNIFFLGSYRETFVNVLGWTVIWTICATTLQIILGIVTAL FVNQDFIKGKRIFRMIFLFPWAVPAFITIMSFSNMFNDSIGAVNAQVIPLFNHLPFVE LPAIAWKTDPFWTKTALIMIQTWLGFPYIYVMVTGVLQAIPGELYEAAKIDGATFIQR FRHITFPMILFATAPVMITQYTFNFNNFSIIYLFNEGGPGSAGAGAGSTDILISWIYK LTTGTSPQYSVAAAVTLLISFIVIGISLIAFKKSNAFGNEEVM*" /label="mdxF CDS" gene complement(3068115..3069422) /gene="mdxF" /locus_tag="BSU_34600" /old_locus_tag="BSU34600" /label="mdxF gene" promotor_-35 3068480..3068489 /Source="Nicolas_upshift_promotors" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3068502..3068521 /Source="Nicolas_upshift_promotors" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3068506 /Source="Nicolas_upshifts" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3069462..3070715) /gene="mdxE" /locus_tag="BSU_34610" /old_locus_tag="BSU34610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16707683" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="maltose/maltodextrin-binding lipoprotein" /protein_id="NP_391341.1" /db_xref="EnsemblGenomes-Gn:BSU34610" /db_xref="EnsemblGenomes-Tr:CAB15466" /db_xref="GOA:O06989" /db_xref="InterPro:IPR006060" /db_xref="SubtiList:BG12416" /db_xref="UniProtKB/Swiss-Prot:O06989" /translation="MVLLKKGFAILAASFLAIGLAACSSSKNPASSDGKKVLTVSVEE TYKEYIESIKTKFEKENDVTVKIVEKQMFEQLEALPLDGPAGNAPDVMLAAYDRIGGL GQQGHLLDIKPSNTKSFGDKEMQQVTVDGKVYGMPLVIETLILYYNKDLLKTAPKTFK DLEKLTEDPRFAFASEKGKSTGFLAKWTDFYMSYGLLAGYGGYVFGKNGTDSGDIGLN NKGAVEAVKYAEKWFETYWPKGMQDNSSADDFIQQMFLEGKAAAIIGGPWSAANYKEA KLNYGAAPIPTLPNGEEYAPFAGGKGWVASKYTKEPELAEKWLEYAANDANAYAFYED TNEVPANTAARKKADEQKNELTSAVIKQYETATPTPNIPEMAEVWTGAESLIFDAASG KKSTQTSANDAVNVIKENIKEKYVK*" /label="mdxE CDS" gene complement(3069462..3070715) /gene="mdxE" /locus_tag="BSU_34610" /old_locus_tag="BSU34610" /label="mdxE gene" S_feature complement(3070716..3070810) /Source="Nicolas_S_feature" /locus_tag="new_3555807_3555901_c" /HighExp="T1.0H, T0.30H, BC, T1.30H, M40t90, M0t90, BI, B60, S8, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.804" /TUlongSig="NA" /TUlongPSig="NA" /label="S1320" CDS complement(3070811..3072580) /gene="mdxD" /locus_tag="BSU_34620" /old_locus_tag="BSU34620" /EC_number="3.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10825545, 15650689, 16707683, 19465663, 27871383, 27871383" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10825545, 15650689, 16707683, 19465663, 27871383, 27871383; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="maltogenic alpha-amylase" /protein_id="NP_391342.1" /db_xref="EnsemblGenomes-Gn:BSU34620" /db_xref="EnsemblGenomes-Tr:CAB15467" /db_xref="GOA:O06988" /db_xref="InterPro:IPR004185" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR013777" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12415" /db_xref="UniProtKB/Swiss-Prot:O06988" /translation="MMEYAAIHHQPFSTDAYSYDGRTVHIKIRTKKGDADHIRFIWGD PYEYNDGKWSANEQPMRKIAATEMHDYWFAEVVPPFRRLQYAFVVTDDHEDIFFGSSG VCPYNEKTLETIHYYFKFPFVHEADTFQAPEWVKSTVWYQIFPERFANGREDLSPKNA LPWGSKDPDVNDFFGGDLQGIVDKLDYLEDLGVNGIYLTPIFSAPSNHKYDTLDYFSI DPHFGDPELFRTLVSQLHQRGMRIMLDAVFNHIGSASPQWQDVVKNGDQSRYKDWFHI HSFPVTDDNYDRFAFTADMPKLNTANPEVQKYLLDIALYWIREFDIDGWRLDVANEVD HVFWKTFRQAVSTEKPDVYILGEIWHSAEPWLRGDEFHAAMNYPFTEPMIEYFADQTI SASRMAHRVNAHLMNGMKQANEVMFNLLDSHDTKRLLTRCRNDEKKARALLAFMFAQT GSPCIYYGTEIGLNGENDPLCRKCMVWEKEKQNQDMLQFMKRLIALRKQENTLLTEGH LEWNLLDDKNDFISFSRTLDEKILIYFFNQGNVVQHVSLRELNIDRNKKICDAWTEQP LQHHDVIAVQPGEFLILSAAAPV*" /label="mdxD CDS" gene complement(3070811..3072580) /gene="mdxD" /locus_tag="BSU_34620" /old_locus_tag="BSU34620" /label="mdxD gene" promotor_-35 3072501..3072506 /Source="Nicolas_upshift_promotors" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3072522..3072540 /Source="Nicolas_upshift_promotors" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3072532 /Source="Nicolas_upshifts" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3072618..3072637) /Source="Nicolas_upshift_promotors" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3072631) /Source="Nicolas_upshifts" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3072650..3072657) /Source="Nicolas_upshift_promotors" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3072693..3073643) /gene="mdxR" /locus_tag="BSU_34630" /old_locus_tag="BSU34630" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16707683, 23951303" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683, 23951303; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the maltodextrin operon (LacI family)" /protein_id="NP_391343.1" /db_xref="EnsemblGenomes-Gn:BSU34630" /db_xref="EnsemblGenomes-Tr:CAB15468" /db_xref="GOA:O06987" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12414" /db_xref="UniProtKB/Swiss-Prot:O06987" /translation="MATLSDVAKKANVSKMTVSRVINHPETVTDELKKLVHSAMKELN YIPNYAARALVQNRTQVVKLLILEEMDTTEPYYMNLLTGISRELDRNHYALQLVTRNS LNIGQCDGIIATGLRKNDFEGVIKAFEKPLVVFGQNEMGYDFIDVNNEKGTFMATRHV MGLGEREVVFFGIDLDEPFERAREQGYIRAMNKSFKKSNMFRIDNSSKKSECLARELL KSMDNQAAFVCASDRIALGVIRAAQSLGKRIPEDVAVTGNDGVFLDRISSPRLTTVRQ PVVEMGEACAKMLLKKMNEDGAAQGSLFFEPELIVRESTL*" /label="mdxR CDS" gene complement(3072693..3073643) /gene="mdxR" /locus_tag="BSU_34630" /old_locus_tag="BSU34630" /label="mdxR gene" promotor_-10 complement(3073658..3073676) /Source="Nicolas_upshift_promotors" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3073671) /Source="Nicolas_upshifts" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3073688..3073696) /Source="Nicolas_upshift_promotors" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3073777) /Source="Nicolas_upshifts" /id="D1792" /incds=0 /nref=134 /ntot=243 /MaxReadThrough="0.22626" /MaxDrop="5.17193" /score="21.4455132" /energy="-10" /TU="NA" /idTUdmin="U2720" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(3073849..3074424) /gene="yvdD" /locus_tag="BSU_34640" /old_locus_tag="BSU34640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_391344.1" /db_xref="EnsemblGenomes-Gn:BSU34640" /db_xref="EnsemblGenomes-Tr:CAB15469" /db_xref="InterPro:IPR005269" /db_xref="InterPro:IPR031100" /db_xref="PDB:1T35" /db_xref="SubtiList:BG12413" /db_xref="UniProtKB/Swiss-Prot:O06986" /translation="MKTICVFAGSNPGGNEAYKRKAAELGVYMAEQGIGLVYGGSRVG LMGTIADAIMENGGTAIGVMPSGLFSGEVVHQNLTELIEVNGMHERKAKMSELADGFI SMPGGFGTYEELFEVLCWAQIGIHQKPIGLYNVNGYFEPMMKMVKYSIQEGFSNESHL KLIHSSSRPDELIEQMQNYSYPILEKKWTEI*" /label="yvdD CDS" gene complement(3073849..3074424) /gene="yvdD" /locus_tag="BSU_34640" /old_locus_tag="BSU34640" /label="yvdD gene" downshifts complement(3073861) /Source="Nicolas_upshifts" /id="D1793" /incds=0 /nref=30 /ntot=209 /MaxReadThrough="4.23893" /MaxDrop="3.6086" /score="21.4455132" /energy="-10" /TU="U2720" /idTUdmin="U2720" /TUdmin="-87" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3074467..3074486) /Source="Nicolas_upshift_promotors" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3074473..3074480 /Source="Nicolas_upshift_promotors" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3074483) /Source="Nicolas_upshifts" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="upshifts" upshifts 3074490 /Source="Nicolas_upshifts" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3074493..3074512 /Source="Nicolas_upshift_promotors" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3074501..3074508) /Source="Nicolas_upshift_promotors" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3074541..3074861 /gene="yvdC" /locus_tag="BSU_34650" /old_locus_tag="BSU34650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16120674, 19684115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pyrophosphohydrolase" /protein_id="NP_391345.1" /db_xref="EnsemblGenomes-Gn:BSU34650" /db_xref="EnsemblGenomes-Tr:CAB15470" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR011411" /db_xref="SubtiList:BG12412" /db_xref="UniProtKB/Swiss-Prot:O32263" /translation="MQLADAEKWMKEFYEKRGWTEYGPFIRVGFLMEEAGELARAVRA YEIGRDRPDEKESSRAEQKQELIEEMGDVIGNIAILADMYGVSLEDVMKAHQEKLTKR FEHA*" /label="yvdC CDS" gene 3074541..3074861 /gene="yvdC" /locus_tag="BSU_34650" /old_locus_tag="BSU34650" /label="yvdC gene" downshifts 3074842 /Source="Nicolas_upshifts" /id="D1794" /incds=0 /nref=134 /ntot=247 /MaxReadThrough="2.19085" /MaxDrop="5.46819" /score="35.8658106" /energy="-11.6" /TU="NA" /idTUdmin="U2721" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3074888) /Source="Nicolas_upshifts" /id="D1795" /incds=0 /nref=13 /ntot=56 /MaxReadThrough="0.462300000000001" /MaxDrop="6.90114" /score="30.4681035" /energy="-11.3" /TU="NA" /idTUdmin="U2722" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(3074888..3076480) /gene="yvdB" /locus_tag="BSU_34660" /old_locus_tag="BSU34660" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative anion transporter" /protein_id="NP_391346.1" /db_xref="EnsemblGenomes-Gn:BSU34660" /db_xref="EnsemblGenomes-Tr:CAB15471" /db_xref="GOA:O06984" /db_xref="InterPro:IPR001902" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR011547" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG12411" /db_xref="UniProtKB/Swiss-Prot:O06984" /translation="MRFSGRFKGYNLQKFQKDLIAGIVVGVVAIPLGMAFAIASGVEP EYGLYTVVIAGICISLFGGSKYQIGGPTGAFVPILFGIIMQYGLENLLIAGFMAGVML VLFGLFKLGKIMKFVPKPVIVGFTAGIAVLIFTEQIANFLGLRNVEKHENFHHNMFEI VQQLGTFNVYAILTAVIGLVILLVSAKVMPKVPGALLALLISTVVAVVFFPDRMATIG STYGEIPRHLPEFQFPELTLDKMVMLFPAALVIALLGGLESILSAMVADNMKGSKHDS NKELVGQGIANMAAPLFGGIPATGAIARTATNIKNGAVSPVSGVVHGVVVLLVLLVFA PYASHVPLASMAPILMVVAWNMSERKEVANMLRLKNADSFILAATFALTVLFDLIIGV ATGLLLAFVFFIRRMSEATRIHNQETHPVLAKREDPSVSMYAIEGPLFFGSIDSLESS LLEHVQKKPKTLILLMNKVHYMDTSAEAVLGNIMNRIKRHNGKLMIVGLQSQPKELLH KTGLFHKIGKQHFFDHHDEITG*" /label="yvdB CDS" gene complement(3074888..3076480) /gene="yvdB" /locus_tag="BSU_34660" /old_locus_tag="BSU34660" /label="yvdB gene" CDS complement(3076499..3077092) /gene="yvdA" /locus_tag="BSU_34670" /old_locus_tag="BSU34670" /EC_number="4.2.1.1" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10611359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carbonic anhydrase" /protein_id="NP_391347.1" /db_xref="EnsemblGenomes-Gn:BSU34670" /db_xref="EnsemblGenomes-Tr:CAB15472" /db_xref="GOA:O06983" /db_xref="InterPro:IPR001765" /db_xref="InterPro:IPR036874" /db_xref="SubtiList:BG12410" /db_xref="UniProtKB/Swiss-Prot:O06983" /translation="MNQMVSLTSILEHNQRFVSEKKYEPYKTTKFPSKKLVIVTCMDT RLTELLPQAMGLKNGDAKIVKNAGAIVSHPFGSVMRSILVAIYELQAEEVCIVGHHEC GMSGLNASSILEKAKERGVEDSCLNLLTSAGLDLKTWLTGFHSVEESVSHSVNMIKNH PLLPKKVPVHGLVIHPETGKLDVVINGYETELINNHS*" /label="yvdA CDS" gene complement(3076499..3077092) /gene="yvdA" /locus_tag="BSU_34670" /old_locus_tag="BSU34670" /label="yvdA gene" promotor_-10 complement(3077134..3077153) /Source="Nicolas_upshift_promotors" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3077147) /Source="Nicolas_upshifts" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3077168..3077172) /Source="Nicolas_upshift_promotors" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3077218..3077223 /Source="Nicolas_upshift_promotors" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3077239..3077257 /Source="Nicolas_upshift_promotors" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3077240 /Source="Nicolas_upshifts" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3077413..3077420 /Source="Nicolas_upshift_promotors" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3077434..3077453 /Source="Nicolas_upshift_promotors" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3077438 /Source="Nicolas_upshifts" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="upshifts" CDS 3077475..3078452 /gene="yvcT" /locus_tag="BSU_34680" /old_locus_tag="BSU34680" /EC_number="1.1.1.215" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9811658, 25769838; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2-ketogluconate reductase; hydroxypyruvate / glyoxylate reductase" /protein_id="NP_391348.1" /db_xref="EnsemblGenomes-Gn:BSU34680" /db_xref="EnsemblGenomes-Tr:CAB15473" /db_xref="GOA:O32264" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR029752" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12409" /db_xref="UniProtKB/Swiss-Prot:O32264" /translation="MLKPFVFITKPIPEEIEAFIGEHCRYEVWQEDTLPSDVLFEKLK EAEGLLTSGTSGPSINRELLEHAPKLKVVSNQSVGYDNFDIEAMKERGVVGTHTPYTL DDTVADLAFSLILSSARRVAELDRFVRAGKWGTVEEEALFGIDVHHQTLGIIGMGRIG EQAARRAKFGFDMEVLYHNRHRKQETEDSIGVKYAELDTLLEQSDFILLITPLTDETY HMIGEREFKLMKNSAIFVNISRGKTVDEKALIRALQEGWIRGAGLDVYEKEPVTQDNP LLQLDNVTLLPHIGSATAKVRFNMCKQAAENMLAAIQGQTPKNLTREFQ*" /label="yvcT CDS" gene 3077475..3078452 /gene="yvcT" /locus_tag="BSU_34680" /old_locus_tag="BSU34680" /label="yvcT gene" downshifts 3078424 /Source="Nicolas_upshifts" /id="D1796" /incds=0 /nref=223 /ntot=269 /MaxReadThrough="2.44036" /MaxDrop="5.93476" /score="1.05732532" /energy="-14.7" /TU="NA" /idTUdmin="U2724" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(3078490..3080430) /gene="psdB" /locus_tag="BSU_34690" /old_locus_tag="BSU34690" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21078927, 27997719; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lantibiotic ABC transporter (permease)" /protein_id="NP_391349.1" /db_xref="EnsemblGenomes-Gn:BSU34690" /db_xref="EnsemblGenomes-Tr:CAB15474" /db_xref="GOA:O06981" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR027022" /db_xref="SubtiList:BG12408" /db_xref="UniProtKB/Swiss-Prot:O06981" /translation="MNLRTIARKNILGNLQRYVAYFLSCVFAVSVFFVFTSFIFHPDV NEDNIYGGSLVKTCLSAALVVIIVFCIFFITYSNSAFLQARKKEFGLLTLFGTSKQQL RKMIYYEQSLISLAAIAAGIGAGLLFSKLFFMIMTWMLSVKVPISFAIVPKAFVMTIA GFLILFQTLLILSLGRIRKLEIIELIKSAKKPKSLPVYSKWLTVLSLLCLGSGYYLSA TANAIDMMFRVFPILILVLIGTYFFFTQSSVAFFRMLYRKKHSFYKGTNIIVRSNMIF RLKDHARMLFLTSVITAVILTATGVIYMFYSDLQRQEEQSIPQSVSWVEKDASRFQVM KPETAENTLKKAHAVITYKVDATGIPVTFQSDLPYGNKKMEAEALLISEKVYNQVAKE KGFPVIHLQENEAFINVSFQMMVKDTFGEGETAAFHMKSGKTLSYVMKKQQNKGILMS VDGVSRLLVVSEKSFDSLSQDVPLKEQMRMVGYELEHWQETVDVSEKLENMVPKEHTS DFQTRAPSYQIVKQGVALMLFIGLFVSVLFFIVQGSMLYLRMFTEIEDTGVQVLALKR IGVTDKEIHSILGKQIGFLFFIPFIAGTIHAGFAYAALSNMLNSNLFLEAVIVIFIYF VFQALYYIVTRHIYKRAVLQRM*" /label="psdB CDS" gene complement(3078490..3080430) /gene="psdB" /locus_tag="BSU_34690" /old_locus_tag="BSU34690" /label="psdB gene" downshifts complement(3078514) /Source="Nicolas_upshifts" /id="D1797" /incds=0 /nref=11 /ntot=187 /MaxReadThrough="0.26118" /MaxDrop="4.59213" /score="26.9028733" /energy="-14.7" /TU="NA" /idTUdmin="U2725" /TUdmin=34 /isTUend="FALSE" /label="downshifts" CDS complement(3080405..3081184) /gene="psdA" /locus_tag="BSU_34700" /old_locus_tag="BSU34700" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12432961, 14651641, 21078927, 27997719; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lantibiotic ABC transporter (ATP-binding protein)" /protein_id="NP_391350.1" /db_xref="EnsemblGenomes-Gn:BSU34700" /db_xref="EnsemblGenomes-Tr:CAB15475" /db_xref="GOA:O06980" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12407" /db_xref="UniProtKB/Swiss-Prot:O06980" /translation="MNVLQTTNLSKTYYSNKGTISYQALSAFDLSVSKGEFVGIMGPS GSGKTTLLNLLATIDKPTQGEMMINGIQPKTLKDQELALFRRRELGFVFQDFNLLDTL TIRENILLPLALDKVKLREMEARLDELADTLQIKHILDHRTYEVSGGQQQRAACARAI IHNPALILADEPTGNLDSKSAKQVMNTLAQLNEEKEATILLVTHDATAASFCKRIVFI KDGRFFSEIHRGTNRQVFYQSILDTLSVLGGDFHEFENYRP*" /label="psdA CDS" gene complement(3080405..3081184) /gene="psdA" /locus_tag="BSU_34700" /old_locus_tag="BSU34700" /label="psdA gene" S_feature complement(3081185..3081266) /Source="Nicolas_S_feature" /locus_tag="new_3566276_3566357_c" /HighExp="LBGtran, M0t45, H2O2, C30, Lbexp, Lbstat, LBGstat, dia0, Paraq, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.999" /label="S1321" CDS complement(3081267..3082337) /gene="psdS" /locus_tag="BSU_34710" /old_locus_tag="BSU34710" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12432961, 14651641, 21078927, 27997719; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [PsdR] response to lantibiotics (nisin and gallidermin)" /protein_id="NP_391351.1" /db_xref="EnsemblGenomes-Gn:BSU34710" /db_xref="EnsemblGenomes-Tr:CAB15476" /db_xref="GOA:O06979" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12406" /db_xref="UniProtKB/Swiss-Prot:O06979" /translation="MLKTYLIDRLAIILFSLLGIGSAMLIAYLSIVESGAEPSKENMM YIWILPGTLLAAGFAADYVRQFSFLTYVKKLAEQASSSNDIGQSLKARKPRTGEQALW TKMINALGQQYESRLSQYINQQKQHYTFTNQWVHHMKTPVSVISLMIQEGKNGTSSSF PTFLEELEDENERFRHGLDMMLQTARLEEFAFDVKPQTFDLAEMVRSLINQEKRQFIK RRLFPTLHVPPNAVQISSDQKWLSFVVEQILFNALKYSKQGVGDPITIRIETQGHETR LSVADEGIGIPPQDLPRIFDAFFTGENGRTMKEATGMGLYLAKQVCSRLGHKLYAESK EGAGTVMTIVFSSDTLVNVTAL*" /label="psdS CDS" gene complement(3081267..3082337) /gene="psdS" /locus_tag="BSU_34710" /old_locus_tag="BSU34710" /label="psdS gene" CDS complement(3082331..3083044) /gene="psdR" /locus_tag="BSU_34720" /old_locus_tag="BSU34720" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12432961, 14651641, 21078927, 27997719; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [PsdS] responding to lipid II-binding lantibiotics (nisin and gallidermin)" /protein_id="NP_391352.1" /db_xref="EnsemblGenomes-Gn:BSU34720" /db_xref="EnsemblGenomes-Tr:CAB15477" /db_xref="GOA:O06978" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12405" /db_xref="UniProtKB/Swiss-Prot:O06978" /translation="MYRILLVEDDERIASLLGGHLQKYGYEVKIAEQLNDIKLEFAEM KPDLVLLDINLPFFDGFYWCRQIRTISNAPIIFISARTDELNQVMAIENGGDDYITKP FHLEVVMAKIKSVLRRTYGEYSPSLPQESRIVELGGLTIYPDQNEAEWNSVRILFSQK EFQLLSIFVREHKKIVSRDELLEALWDDVDFVDDNTLTVNVNRLRRKLENAGLTDCIS TIRGQGYQFQVNRKDEAEC*" /label="psdR CDS" gene complement(3082331..3083044) /gene="psdR" /locus_tag="BSU_34720" /old_locus_tag="BSU34720" /label="psdR gene" promotor_-10 complement(3083090..3083109) /Source="Nicolas_upshift_promotors" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3083102) /Source="Nicolas_upshifts" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3083104..3083365) /Source="Nicolas_S_feature" /locus_tag="new_3568195_3568456_c" /HighExp="H2O2, G135, G180, Cold, Paraq, G150, dia15, Oxctl, LBGexp, C30" /AntisenseName="yvzJ" /AntisenseCor="0.56014644713727801" /AntisenseRegPval="-22.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.999" /label="S1322" promotor_-35 complement(3083122..3083125) /Source="Nicolas_upshift_promotors" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3083125..3083132 /Source="Nicolas_upshift_promotors" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3083143..3083162 /Source="Nicolas_upshift_promotors" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3083148 /Source="Nicolas_upshifts" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="upshifts" CDS 3083191..3083400 /gene="yvzJ" /locus_tag="BSU_34729" /old_locus_tag="BSU34729" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="YP_003097790.1" /db_xref="EnsemblGenomes-Gn:BSU34729" /db_xref="EnsemblGenomes-Tr:CAX52696" /db_xref="GOA:C0H3R7" /db_xref="UniProtKB/Swiss-Prot:C0H3R7" /translation="MKKIMLFLAMTSILSACQPNYTGKYIEIGDTLTDYTKECFKENE IPYKYEKGKLYIPEDAFDTAIYTCS*" /label="yvzJ CDS" gene 3083191..3083400 /gene="yvzJ" /locus_tag="BSU_34729" /old_locus_tag="BSU34729" /label="yvzJ gene" downshifts 3083378 /Source="Nicolas_upshifts" /id="D1798" /incds=0 /nref=7 /ntot=138 /MaxReadThrough="1.16039" /MaxDrop="3.61604" /score="-5.58790836" /energy="-11.4" /TU="NA" /idTUdmin="U2726" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3083410) /Source="Nicolas_upshifts" /id="D1799" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="3.16808" /MaxDrop="2.84175" /score="16.7711538" /energy="-11.5" /TU="U2727,U2729" /idTUdmin="U2728" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(3083436..3084200) /gene="yvcN" /locus_tag="BSU_34730" /old_locus_tag="BSU34730" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10876241; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative arylamine N-acetyltransferase" /protein_id="NP_391353.1" /db_xref="EnsemblGenomes-Gn:BSU34730" /db_xref="EnsemblGenomes-Tr:CAB15478" /db_xref="GOA:O06977" /db_xref="InterPro:IPR001447" /db_xref="SubtiList:BG12404" /db_xref="UniProtKB/Swiss-Prot:O06977" /translation="MIKMSDFLKDCFQKIGWEKDHVSFGDLPLFLKAMAYRFPFENRA VLAKENYKITKEELWRRLLKDQHGGLCYDLNGFLYFVLREAGFHVKLIRGTVYAGDQE GWALEGTHAAVWLSAENGDYLVDIGFGINLALQPIPLSGETVQSPVGSFRIKKEETEK GSYVLLMDKGEGWQIGYAFTLEESDLGDLDNMKDIIHSHEKSPFNKSLLASKLTPSGR MVMSERHFTIYENGGNIQKSDIGPSGFEEKLNTHFL*" /label="yvcN CDS" gene complement(3083436..3084200) /gene="yvcN" /locus_tag="BSU_34730" /old_locus_tag="BSU34730" /label="yvcN gene" downshifts complement(3083458) /Source="Nicolas_upshifts" /id="D1800" /incds=0 /nref=143 /ntot=253 /MaxReadThrough="3.19848" /MaxDrop="6.45069" /score="16.7711538" /energy="-11.5" /TU="U2727,U2729" /idTUdmin="U2728" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(3084201..3084458) /gene="crh" /locus_tag="BSU_34740" /old_locus_tag="BSU34740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10559153, 10589728, 1136107, 12972249, 15126459, 16411239, 17142398, 21992469, 22092971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559153, 10589728, 1136107, 12972249, 15126459, 16411239, 17142398, 21992469, 22092971; Product type r: regulator" /codon_start=1 /transl_table=11 /product="catabolite repression HPr-like protein" /protein_id="NP_391354.1" /db_xref="EnsemblGenomes-Gn:BSU34740" /db_xref="EnsemblGenomes-Tr:CAB15479" /db_xref="InterPro:IPR000032" /db_xref="InterPro:IPR002114" /db_xref="InterPro:IPR035895" /db_xref="PDB:1K1C" /db_xref="PDB:1MO1" /db_xref="PDB:1MU4" /db_xref="PDB:1ZVV" /db_xref="PDB:2AK7" /db_xref="PDB:2RLZ" /db_xref="SubtiList:BG12403" /db_xref="UniProtKB/Swiss-Prot:O06976" /translation="MVQQKVEVRLKTGLQARPAALFVQEANRFTSDVFLEKDGKKVNA KSIMGLMSLAVSTGTEVTLIAQGEDEQEALEKLAAYVQEEV*" /label="crh CDS" gene complement(3084201..3084458) /gene="crh" /locus_tag="BSU_34740" /old_locus_tag="BSU34740" /label="crh gene" CDS complement(3084482..3085432) /gene="whiA" /locus_tag="BSU_34750" /old_locus_tag="BSU34750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10986251, 17603302, 19836336, 24097947; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative morphogen" /protein_id="NP_391355.1" /db_xref="EnsemblGenomes-Gn:BSU34750" /db_xref="EnsemblGenomes-Tr:CAB15480" /db_xref="GOA:O06975" /db_xref="InterPro:IPR003802" /db_xref="InterPro:IPR018478" /db_xref="InterPro:IPR023054" /db_xref="InterPro:IPR027434" /db_xref="InterPro:IPR033981" /db_xref="SubtiList:BG12402" /db_xref="UniProtKB/Swiss-Prot:O06975" /translation="MSFASETKKELTNLEVKDCCINAELSALIRMNGALSFTNRHLVL DVQTENAAIARRIYTLLKKQYDVSVELLVRKKMRLKKNNVYIVRFSENAKAILEDLKI LGENFVFERSISKELVKKRCCKRSYMRGAFLAGGSVNNPETSSYHLEIFSLYKEHNDS LCDLLNEFQLNSKTLERKKGYITYLKEAEKITEFLNVIGAHNSLLRFEDVRIVRDMRN SVNRLVNCETANLNKTIGASLRQVENIKYIDERIGLEALPEKLREIAQLRIDYQEVTL KELGEMVASGKISKSGINHRLRKLDEIAEQLRTGQTVTLK*" /label="whiA CDS" gene complement(3084482..3085432) /gene="whiA" /locus_tag="BSU_34750" /old_locus_tag="BSU34750" /label="whiA gene" CDS complement(3085455..3086408) /gene="mgfK" /locus_tag="BSU_34760" /old_locus_tag="BSU34760" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11888293, 16272399, 21320184, 21371139, 25012659, 27806131, 28646159" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11888293, 16272399, 21320184, 21371139, 25012659, 27806131, 28646159; Product type f: factor" /codon_start=1 /transl_table=11 /product="gluconeogenesis morphogenetic factor (UDP-sugar binding)" /protein_id="NP_391356.2" /db_xref="EnsemblGenomes-Gn:BSU34760" /db_xref="EnsemblGenomes-Tr:CAB15481" /db_xref="GOA:O06974" /db_xref="InterPro:IPR002882" /db_xref="InterPro:IPR010119" /db_xref="SubtiList:BG12401" /db_xref="UniProtKB/Swiss-Prot:O06974" /translation="MGQKPKIAIFGGGTGLSVLLRGLKHKPVDITAIVTVADDGGSSG RLRNELKIPPPGDIRNVLAALSDVEPLVEDLFQHRFNKGNDLTGHSLGNLILAAMTNI TGDFFHAVTEMSKVLNVRGKVLPAANASVVLHAEMEDGRVVSGESTIPEYGQRIKRVF LTPEQIDPLPETIDVIREADLIIIGPGSLYTSILPNLLVPKIGEEVIKAPAKKVYICN VMTQPGETLHYTAADHVKALNQHMGCGFIDTILVNSEDIPDEIKRKYEMESARPVDFD IEELKAMGLEVIRDQIVTYKNDVIRHDTHKVASLLVDLLKE*" /label="mgfK CDS" gene complement(3085455..3086408) /gene="mgfK" /locus_tag="BSU_34760" /old_locus_tag="BSU34760" /label="mgfK gene" CDS complement(3086410..3087297) /gene="yvcJ" /locus_tag="BSU_34770" /old_locus_tag="BSU34770" /function="15.6: DNA transformation" /experiment="publication(s) with functional evidences, PMID:18334534, 19074378, 21179021, 21709426" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18334534, 19074378, 21179021, 21709426; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase possibly involved in regulator sRNA degradation" /protein_id="NP_391357.1" /db_xref="EnsemblGenomes-Gn:BSU34770" /db_xref="EnsemblGenomes-Tr:CAB15482" /db_xref="GOA:O06973" /db_xref="InterPro:IPR005337" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12400" /db_xref="UniProtKB/Swiss-Prot:O06973" /translation="MSVSESHDIQLVIITGMSGAGKTVAIQSFEDLGYFCVDNLPPSL LPKFLELMKESNSKMSKVALVMDLRGREFFDRLIEALDEMAENPWITPRILFLDAKDS ILVTRYKETRRSHPLAATGLPLEGIALERELLEELKGRSQIIYDTSDMKPRDLREKIV KHFATNQGETFTVNVMSFGFKYGIPIDADLVFDVRFLPNPYYIESMRPLTGKDKEVSS YVMKWNETQKFNEKLIDLLSFMLPSYKREGKSQVVIAIGCTGGQHRSVTLAENLADYF KKDYYTHVTHRDIEKRSRK*" /label="yvcJ CDS" gene complement(3086410..3087297) /gene="yvcJ" /locus_tag="BSU_34770" /old_locus_tag="BSU34770" /label="yvcJ gene" CDS complement(3087322..3087798) /gene="yvcI" /locus_tag="BSU_34780" /old_locus_tag="BSU34780" /EC_number="3.6.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative triphosphate pyrophosphate hydrolase" /protein_id="NP_391358.1" /db_xref="EnsemblGenomes-Gn:BSU34780" /db_xref="EnsemblGenomes-Tr:CAB15483" /db_xref="GOA:O06972" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG12399" /db_xref="UniProtKB/Swiss-Prot:O06972" /translation="MTYLQRVTNCVLQTDDKVLLLQKPRRGWWVAPGGKMESGESVRD SVIREYREETGIYIINPQLKGVFTFIIKDGDHIVSEWMMFTFVADSYTGQNVSESEEG KLQWHDVNDIQNLPMAPGDGHILDFMMKGQGLLHGTFTYTPEFELLSYRLDPQHIK*" /label="yvcI CDS" gene complement(3087322..3087798) /gene="yvcI" /locus_tag="BSU_34780" /old_locus_tag="BSU34780" /label="yvcI gene" promotor_-10 complement(3087818..3087837) /Source="Nicolas_upshift_promotors" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3087832) /Source="Nicolas_upshifts" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3087853..3087857) /Source="Nicolas_upshift_promotors" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3087876..3087895) /Source="Nicolas_upshift_promotors" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3087889) /Source="Nicolas_upshifts" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3087910..3087913) /Source="Nicolas_upshift_promotors" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3087965..3088115) /Source="Nicolas_S_feature" /locus_tag="new_3573056_3573206_c" /HighExp="dia15, Diami, dia5, H2O2, Etha, LPhT, Cold, Paraq, C30, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1323" downshifts complement(3088008) /Source="Nicolas_upshifts" /id="D1801" /incds=0 /nref=9 /ntot=78 /MaxReadThrough="6.94979" /MaxDrop="3.73811" /score="11.9453839" /energy="-11" /TU="U2729,U2733" /idTUdmin="U2734" /TUdmin=2904 /isTUend="FALSE" /label="downshifts" CDS complement(3088116..3089066) /gene="trxB" /locus_tag="BSU_34790" /old_locus_tag="BSU34790" /EC_number="1.8.1.9" /function="16.6: Maintain" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14597697, 15659166, 23813734, 24401092" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14597697, 15659166, 23813734, 24401092; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thioredoxin reductase" /protein_id="NP_391359.1" /db_xref="EnsemblGenomes-Gn:BSU34790" /db_xref="EnsemblGenomes-Tr:CAB15484" /db_xref="GOA:P80880" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR005982" /db_xref="InterPro:IPR008255" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12398" /db_xref="UniProtKB/Swiss-Prot:P80880" /translation="MSEEKIYDVIIIGAGPAGMTAAVYTSRANLSTLMIERGIPGGQM ANTEDVENYPGFESILGPELSNKMFEHAKKFGAEYAYGDIKEVIDGKEYKVVKAGSKE YKARAVIIAAGAEYKKIGVPGEKELGGRGVSYCAVCDGAFFKGKELVVVGGGDSAVEE GVYLTRFASKVTIVHRRDKLRAQSILQARAFDNEKVDFLWNKTVKEIHEENGKVGNVT LVDTVTGEESEFKTDGVFIYIGMLPLSKPFENLGITNEEGYIETNDRMETKVEGIFAA GDIREKSLRQIVTATGDGSIAAQSVQHYVEELQETLKTLK*" /label="trxB CDS" gene complement(3088116..3089066) /gene="trxB" /locus_tag="BSU_34790" /old_locus_tag="BSU34790" /label="trxB gene" S_feature complement(3089067..3089154) /Source="Nicolas_S_feature" /locus_tag="new_3574158_3574245_c" /HighExp="dia5, Diami, dia15, H2O2, Etha, Salt, Cold, Paraq, LPhT, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1324" promotor_-10 complement(3089143..3089162) /Source="Nicolas_upshift_promotors" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3089154) /Source="Nicolas_upshifts" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3089156..3089247) /Source="Nicolas_S_feature" /locus_tag="new_3574247_3574338_c" /HighExp="Cold, Oxctl, G180, G135, Paraq, C30, LBGexp, G150, S1, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1325" promotor_-35 complement(3089177..3089180) /Source="Nicolas_upshift_promotors" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3089195..3089201 /Source="Nicolas_upshift_promotors" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3089215..3089233 /Source="Nicolas_upshift_promotors" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3089229 /Source="Nicolas_upshifts" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="upshifts" S_feature 3089230..3092616 /Source="Nicolas_S_feature" /locus_tag="new_3574321_3577707" /HighExp="Sw, M9-stat, B60, T0.30H, Gly, BC, B36, T1.0H, Salt, C30" /AntisenseName="yvcD" /AntisenseCor="-0.261780844003138" /AntisenseRegPval="-4.9000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1326" CDS complement(3089272..3090693) /gene="cwlO" /locus_tag="BSU_34800" /old_locus_tag="BSU34800" /EC_number="3.4.-.-" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15187182, 16233686, 21478646, 22139507, 23855774, 24163346, 24769902" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 16233686, 21478646, 22139507, 23855774, 24163346, 24769902; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted cell wall DL-endopeptidase" /protein_id="NP_391360.1" /db_xref="EnsemblGenomes-Gn:BSU34800" /db_xref="EnsemblGenomes-Tr:CAB15485" /db_xref="GOA:P40767" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG11023" /db_xref="UniProtKB/Swiss-Prot:P40767" /translation="MRKSLITLGLASVIGTSSFLIPFTSKTASAETLDEKKQKIESKQ SEVASSIEAKEKELTELQENQSKIEKELKDINDKALDTSNKIEDKKEENDKTKEEIKK LKKEIKETEARIEKRNEILKKRVRSLQESGGSQGYIDVLLGSTSFGDFISRATAVSSI VDADKDLIKQQEQDKAKLEDSEADLNDKLKEVQAALAKLETMQKDLDKQLNEKDKLFD EAKASQKKTAKAISELKSEASELANQKANTEAEQARIKKEQEAAAALIKKQEEAQKAS DETQTDDSQTATTESSKASSSDDSSDNSSDNSSNGSSNSSSNGSSSKKSSGSNSNSGG TVISNSGGIEGAISVGSSIVGQSPYKFGGGRTQSDINNRIFDCSSFVRWAYASAGVNL GPVGGTTTDTLVGRGQAVSASEMKRGDLVFFDTYKTNGHVGIYLGNGTFLNDNTSHGV SVDSMSNPYWKAAFKGVVRRVVQ*" /label="cwlO CDS" gene complement(3089272..3090693) /gene="cwlO" /locus_tag="BSU_34800" /old_locus_tag="BSU34800" /label="cwlO gene" downshifts complement(3089292) /Source="Nicolas_upshifts" /id="D1802" /incds=0 /nref=8 /ntot=106 /MaxReadThrough="6.31311" /MaxDrop="3.4602" /score="1.76249731" /energy="-12.1" /TU="U2733" /idTUdmin="U2734" /TUdmin=1620 /isTUend="FALSE" /label="downshifts" downshifts complement(3089416) /Source="Nicolas_upshifts" /id="D1803" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="7.07718" /MaxDrop="2.13349" /score="1.76249731" /energy="-12.1" /TU="U2733" /idTUdmin="U2734" /TUdmin=1496 /isTUend="FALSE" /label="downshifts" misc_feature 3090320..3090324 /Source="Nicolas_upshift_promotors" /id="U2731" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.963036963036963" /psig="0.002997002997003" /xcortree=52 /SigmaFactorBS="aaagaacatctatgtatccttgagatccgccgctttcctgta aagaacgaACGCGttttttcaggatttcattgcgtttttcgatgcgtgcttcagtttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3090330 /Source="Nicolas_upshifts" /id="U2731" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.963036963036963" /psig="0.002997002997003" /xcortree=52 /SigmaFactorBS="aaagaacatctatgtatccttgagatccgccgctttcctgta aagaacgaACGCGttttttcaggatttcattgcgtttttcgatgcgtgcttcagtttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3090609..3090613 /Source="Nicolas_upshift_promotors" /id="U2732" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.84015984015984" /psig="0.130869130869131" /xcortree=42 /SigmaFactorBS="ctcagattgcttgctttcgattttttgtttcttttcatctaa tgtttccgccgATGCAgttttacttgtaaatgggatcaaaaaactgcttgtcccgatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3090616 /Source="Nicolas_upshifts" /id="U2732" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.84015984015984" /psig="0.130869130869131" /xcortree=42 /SigmaFactorBS="ctcagattgcttgctttcgattttttgtttcttttcatctaa tgtttccgccgATGCAgttttacttgtaaatgggatcaaaaaactgcttgtcccgatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3090694..3090891) /Source="Nicolas_S_feature" /locus_tag="new_3575785_3575982_c" /HighExp="S1, Cold, T-3.40H, M9-exp, MG t5, MG 5, MG 15, T-5.40H, GM-0.2, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1327" downshifts 3090814 /Source="Nicolas_upshifts" /id="D1804" /incds=0 /nref=2 /ntot=119 /MaxReadThrough="6.41604" /MaxDrop="3.8522" /score="6.14322693" /energy="-7.6" /TU="U2730,U2731" /idTUdmin="U2731" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3090879..3090898) /Source="Nicolas_upshift_promotors" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_-10" upshifts complement(3090891) /Source="Nicolas_upshifts" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="upshifts" promotor_-35 complement(3090910..3090917) /Source="Nicolas_upshift_promotors" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_-35" CDS complement(3091074..3092528) /gene="yvcD" /locus_tag="BSU_34810" /old_locus_tag="BSU34810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391361.1" /db_xref="EnsemblGenomes-Gn:BSU34810" /db_xref="EnsemblGenomes-Tr:CAB15486" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG12396" /db_xref="UniProtKB/Swiss-Prot:O06968" /translation="MGKHTSEHKNHAQIVQLLQDGQYFFHKGLKAYKERNLKRASKLI QRAVHLEPEDSEMLSQLAVIYSEMGQYQESNDLLDYIMANLEAEMPECHYFKANNFAH LGLFQEAYKEAAAYSDADPDGEFAEENDSLLDLLDLGDDGIEDSLYDQDELLVKQDRA KSLLESGQLAEAVAALEEITTEYPELWSAYNNLALAYFYSGNVVKAKQTAYEVLSHNE GNLHALCNLLVFYYYEREDEKVAELSDQLSNVYPMLLEQRYKLGATLALVGRYEIGYK WLKSLYKTGFEGDDTFFYWLSCSAYFTGHTDFAETIWRKVESQYPGEDRPAPWIERRE ALPSSVEQRLAAYYISSTKGETEHLEAVIRSKRITAPFETHFVKLLLNGDSAAADVSE DALFAYQTVKLLEQAEKEEMKTEVMSCWVFHVIQQIRAAAPLKNEKGWAAAICYIWKE AHGKQDTKKDTAARFGISPATLTKYMKYIDDILE*" /label="yvcD CDS" gene complement(3091074..3092528) /gene="yvcD" /locus_tag="BSU_34810" /old_locus_tag="BSU34810" /label="yvcD gene" downshifts complement(3091094) /Source="Nicolas_upshifts" /id="D1805" /incds=0 /nref=11 /ntot=190 /MaxReadThrough="3.36188" /MaxDrop="3.98985" /score="16.3455178" /energy="-9.1" /TU="U2734" /idTUdmin="U2734" /TUdmin="-182" /isTUend="FALSE" /label="downshifts" S_feature complement(3092529..3092653) /Source="Nicolas_S_feature" /locus_tag="new_3577620_3577744_c" /HighExp="LBGstat, Sw, Cold, BC, BI, Lbexp, dia0, G150, LBGtran, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1328" downshifts 3092574 /Source="Nicolas_upshifts" /id="D1806" /incds=0 /nref=4 /ntot=36 /MaxReadThrough="1.81602" /MaxDrop="3.41181" /score="7.59889121" /energy="-9.9" /TU="NA" /idTUdmin="U2730" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3092654..3094423) /gene="bmrA" /locus_tag="BSU_34820" /old_locus_tag="BSU34820" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16405427, 18215075, 21077936, 22711831, 24630999" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16405427, 18215075, 21077936, 22711831, 24630999; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux transporter (ATP-binding and permease protein)" /protein_id="NP_391362.1" /db_xref="EnsemblGenomes-Gn:BSU34820" /db_xref="EnsemblGenomes-Tr:CAB15487" /db_xref="GOA:O06967" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG12395" /db_xref="UniProtKB/Swiss-Prot:O06967" /translation="MPTKKQKSKSKLKPFFALVRRTNPSYGKLAFALALSVVTTLVSL LIPLLTKQLVDGFSMSNLSGTQIGLIALVFFVQAGLSAYATYALNYNGQKIISGLREL LWKKLIKLPVSYFDTNASGETVSRVTNDTMVVKELITTHISGFITGIISVIGSLTILF IMNWKLTLLVLVVVPLAALILVPIGRKMFSISRETQDETARFTGLLNQILPEIRLVKA SNAEDVEYGRGKMGISSLFKLGVREAKVQSLVGPLISLVLMAALVAVIGYGGMQVSSG ELTAGALVAFILYLFQIIMPMGQITTFFTQLQKSIGATERMIEILAEEEEDTVTGKQI ENAHLPIQLDRVSFGYKPDQLILKEVSAVIEAGKVTAIVGPSGGGKTTLFKLLERFYS PTAGTIRLGDEPVDTYSLESWREHIGYVSQESPLMSGTIRENICYGLERDVTDAEIEK AAEMAYALNFIKELPNQFDTEVGERGIMLSGGQRQRIAIARALLRNPSILMLDEATSS LDSQSEKSVQQALEVLMEGRTTIVIAHRLSTVVDADQLLFVEKGEITGRGTHHELMAS HGLYRDFAEQQLKMNADLENKAG*" /label="bmrA CDS" gene complement(3092654..3094423) /gene="bmrA" /locus_tag="BSU_34820" /old_locus_tag="BSU34820" /label="bmrA gene" S_feature complement(3094424..3094498) /Source="Nicolas_S_feature" /locus_tag="new_3579515_3579589_c" /HighExp="LBGstat, Cold, Lbexp, G150, Oxctl, dia0, T1.30H, T0.30H, BC, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1329" misc_feature complement(3094487..3094506) /Source="Nicolas_upshift_promotors" /id="U2734" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig="0.999000999001" /xcortree=2142 /SigmaFactorBS="gggagatttttattttgatcacggcaaaaatatactgaaaaa gtctttctccATTGATATGATTGAGAAAGAgtaaaaatcatccttttgctatgacttt t" /listShort="S1329, bmrA, S1328, yvcD" /listLong="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3094498) /Source="Nicolas_upshifts" /id="U2734" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig="0.999000999001" /xcortree=2142 /SigmaFactorBS="gggagatttttattttgatcacggcaaaaatatactgaaaaa gtctttctccATTGATATGATTGAGAAAGAgtaaaaatcatccttttgctatgacttt t" /listShort="S1329, bmrA, S1328, yvcD" /listLong="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="upshifts" CDS complement(3094588..3094947) /gene="yvzA" /locus_tag="BSU_34830" /old_locus_tag="BSU34830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391363.1" /db_xref="EnsemblGenomes-Gn:BSU34830" /db_xref="EnsemblGenomes-Tr:CAB15488" /db_xref="SubtiList:BG14157" /db_xref="UniProtKB/Swiss-Prot:O32265" /translation="MTSLFSESETEIVSTTYMFLTQDEMKGKAGTLNQPINDFLSLTK KFESSLKEEIKGQKGLIVKKIKKELESNSEKRKAALQMIKEEHTAKVDRYKMIIEDLR QQDVTLTYRKKKPVKDV*" /label="yvzA CDS" gene complement(3094588..3094947) /gene="yvzA" /locus_tag="BSU_34830" /old_locus_tag="BSU34830" /label="yvzA gene" downshifts complement(3094608) /Source="Nicolas_upshifts" /id="D1807" /incds=0 /nref=146 /ntot=246 /MaxReadThrough="2.52417" /MaxDrop="4.81771" /score="18.5636016" /energy="-13.2" /TU="NA" /idTUdmin="U2735" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3094962..3096872) /gene="yvcB" /locus_tag="BSU_34840" /old_locus_tag="BSU34840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391364.1" /db_xref="EnsemblGenomes-Gn:BSU34840" /db_xref="EnsemblGenomes-Tr:CAB15489" /db_xref="SubtiList:BG12394" /db_xref="UniProtKB/Swiss-Prot:O06966" /translation="MGNKNVFENENVKLRLIDLEYDYKQKFASTIASEVKKAKKDFEA DIRRIYKEETHHDLPENMKIEIYTSNELVNQNTSIQSSTRESGYDGTAIHIIDEKKHI DQLQIISEGSADNKDWSYNFFGLFLGIDHSQYEATKEFTNKAKKAAGNSEDLKTFALG HSLANNNQVMVQLIDGEYDEVYGVNGAQVNIDQLLETDESLYRYVIRKFSYKYEDIDS IPPEKLKKEIQKYYEDKGVTTNITQRISKDDPLYGVSGKADFITFGDVKMADTNTSVK GIRNIMDGVPDEDVRSIQKFLQKYKDDYEKDGLNGFIKAASGIDIDLIEKVKNTDGAL KKVSVLYEHFDDVKQMYGRIKEELPSFLGFLHTLLRNSGPVVDQLAENGYIDETQKKV IKKELTNINASMRGIESRYEHFIDHLKHGQFMQALKDVGEIVDYVKSILSSLKTLDTE TKDALKLIVDGHSIVQMLNALSKEKGFSYKGSDIYFTGKSGSGETIQVNLSSAVRIYQ NGMKIVEDMEDAISKYQKVYSQEIDEDFIDKKQAIITAIHHMEENPSHYAFDLQFRLA AGFSHTFDKLEKISVHESFHTGALPANDGIVAELKKQTTEKRDFIKNIRESIEKLFEK EEMISQLFDFQS*" /label="yvcB CDS" gene complement(3094962..3096872) /gene="yvcB" /locus_tag="BSU_34840" /old_locus_tag="BSU34840" /label="yvcB gene" CDS complement(3096874..3097599) /gene="yvcA" /locus_tag="BSU_34850" /old_locus_tag="BSU34850" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17590234; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391365.1" /db_xref="EnsemblGenomes-Gn:BSU34850" /db_xref="EnsemblGenomes-Tr:CAB15490" /db_xref="GOA:O06965" /db_xref="SubtiList:BG12393" /db_xref="UniProtKB/Swiss-Prot:O06965" /translation="MKKIIFICFSLLLALTGGCSMNDNDKNSTNDNKTEAVKPKDMDP KDLPQVPAFQDEKTREYMVSTKEEEPGYYLLESKLKGFRMLFPEDGKYLSRRSSLTGK NKESIGFNSYDKDTNVMFDGHVTYYKEESFANEPKTMLDIVSGKNDYKGEYKKSSKKK TDIYTAKKKDIFDDIDRKYNYSYSYFGYVKSTEEDNLGVEYAFTLGCKNENQPCSLDE EKAKNKVEKLINSITFLIDKKEK*" /label="yvcA CDS" gene complement(3096874..3097599) /gene="yvcA" /locus_tag="BSU_34850" /old_locus_tag="BSU34850" /label="yvcA gene" S_feature complement(3097600..3097688) /Source="Nicolas_S_feature" /locus_tag="new_3582691_3582779_c" /HighExp="T1.30H, T0.30H, T1.0H, T2.0H, T2.30H, T3.0H, T-1.40H, T-1.10H, MG 150, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.982, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1330" promotor_-10 complement(3097688..3097707) /Source="Nicolas_upshift_promotors" /id="U2735" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.982017982017982" /xcortree=2982 /SigmaFactorBS="tcaaaaccgagtctcatttcctATTTatccaaattccgccaT GATGTAACATGAAAAAGGAtgaaataatcatctcttaaccaggtcaatagaattattt t" /listShort="S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3097688) /Source="Nicolas_upshifts" /id="U2735" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.982017982017982" /xcortree=2982 /SigmaFactorBS="tcaaaaccgagtctcatttcctATTTatccaaattccgccaT GATGTAACATGAAAAAGGAtgaaataatcatctcttaaccaggtcaatagaattattt t" /listShort="S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3097690..3097819) /Source="Nicolas_S_feature" /locus_tag="new_3582781_3582910_c" /HighExp="Etha, Diami, HiTm, T1.0H, Cold, MG 15, T0.30H, BMM, T1.30H, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1331" promotor_-35 complement(3097723..3097726) /Source="Nicolas_upshift_promotors" /id="U2735" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.982017982017982" /xcortree=2982 /SigmaFactorBS="tcaaaaccgagtctcatttcctATTTatccaaattccgccaT GATGTAACATGAAAAAGGAtgaaataatcatctcttaaccaggtcaatagaattattt t" /listShort="S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3097845..3098474) /gene="hisIE" /locus_tag="BSU_34860" /old_locus_tag="BSU34860" /EC_number="3.5.4.19" /EC_number="3.6.1.31" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15871048, 17767732; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase" /protein_id="NP_391366.1" /db_xref="EnsemblGenomes-Gn:BSU34860" /db_xref="EnsemblGenomes-Tr:CAB15491" /db_xref="GOA:O34912" /db_xref="InterPro:IPR002496" /db_xref="InterPro:IPR008179" /db_xref="InterPro:IPR021130" /db_xref="InterPro:IPR023019" /db_xref="InterPro:IPR026660" /db_xref="SubtiList:BG12603" /db_xref="UniProtKB/Swiss-Prot:O34912" /translation="MKQADELRFNEDGLIPAIVQDAASKEVLTLAYMNKESYEKTLET KETWFYSRSRQALWHKGETSGNTQAVKGIRYDCDQDALLVLVEPSGPACHTGSYSCFT KEQTEEQAADRFGIMNELERVIAERQAEMPEGAYTTYLFREGVDKILKKVGEEASEVI IAAKNRDHEELKWEAADLLYHLLVLLREQSLPLDDVLDVLKKRHSEIEE*" /label="hisIE CDS" gene complement(3097845..3098474) /gene="hisIE" /locus_tag="BSU_34860" /old_locus_tag="BSU34860" /label="hisIE gene" downshifts complement(3097864) /Source="Nicolas_upshifts" /id="D1808" /incds=0 /nref=104 /ntot=178 /MaxReadThrough="4.37156" /MaxDrop="4.76747" /score="14.9565762" /energy="-8.4" /TU="U2738" /idTUdmin="U2735" /TUdmin="-3256" /isTUend="FALSE" /label="downshifts" CDS complement(3098471..3099229) /gene="hisF" /locus_tag="BSU_34870" /old_locus_tag="BSU34870" /EC_number="4.3.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 17767732, 19636909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazole glycerol phosphate synthase subunit" /protein_id="NP_391367.1" /db_xref="EnsemblGenomes-Gn:BSU34870" /db_xref="EnsemblGenomes-Tr:CAB15492" /db_xref="GOA:O34727" /db_xref="InterPro:IPR004651" /db_xref="InterPro:IPR006062" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG12600" /db_xref="UniProtKB/Swiss-Prot:O34727" /translation="MITKRIIPCLDVKEGRVVKGIQFLELKDAGDPVELAEVYDREGA DELVFLDISASHEGRKTMVDVVEQVAAKLAIPFTVGGGINQLSDMKTILRAGADKVSV NTAAVLRPELITEGAEFFGSQCIVLAIDAKYDKESDTYKVYTHGGRKKTDWEVTAWAK EGVKRGAGEILLTSMDSDGEKKGFDHTLTKLVSEAVPVPVIASGGAGNAQHMLEAFTK GEADAALAASIFHYKETSIKEVKSYLKEYGVNVR*" /label="hisF CDS" gene complement(3098471..3099229) /gene="hisF" /locus_tag="BSU_34870" /old_locus_tag="BSU34870" /label="hisF gene" CDS complement(3099226..3099963) /gene="hisA" /locus_tag="BSU_34880" /old_locus_tag="BSU34880" /EC_number="5.3.1.16" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 26294764; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase" /protein_id="NP_391368.1" /db_xref="EnsemblGenomes-Gn:BSU34880" /db_xref="EnsemblGenomes-Tr:CAB15493" /db_xref="GOA:O35006" /db_xref="InterPro:IPR006062" /db_xref="InterPro:IPR006063" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023016" /db_xref="SubtiList:BG12597" /db_xref="UniProtKB/Swiss-Prot:O35006" /translation="MSAFTLYPAIDMRNGKCVRLVQGDYNKETIYGDSPYDMAELFEK EGAEWIHLVDLDGAKEGKRVNDRHVIEIAQKLNLKVEIGGGIRSENDVYEYLSAGVER VILGSSAVSNPPFVKKMLKQYGEKIAIGLDARNGFVSTEGWLETSTLKATELGKELAN EGAEVFIFTDIATDGMLSGPNVKSTVELAKETGKSVIASGGVSSVADLEALARNEADG VSGAIIGKALYTNQFTLSEALERVKRK*" /label="hisA CDS" gene complement(3099226..3099963) /gene="hisA" /locus_tag="BSU_34880" /old_locus_tag="BSU34880" /label="hisA gene" CDS complement(3099960..3100598) /gene="hisH" /locus_tag="BSU_34890" /old_locus_tag="BSU34890" /EC_number="2.4.2.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14585832, 15301532" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14585832, 15301532; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazole glycerol phosphate synthase, glutamineamidotransferase subunit" /protein_id="NP_391369.1" /db_xref="EnsemblGenomes-Gn:BSU34890" /db_xref="EnsemblGenomes-Tr:CAB15494" /db_xref="GOA:O34565" /db_xref="InterPro:IPR010139" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12602" /db_xref="UniProtKB/Swiss-Prot:O34565" /translation="MIGVIDYGMGNLYSVSKALERVGVPYFVSEKPEELKEADAFILP GVGSFGDAMDNLGYTKLDQLIHDMVSEGRLLLGICLGMQLLFEESEENGTASGLGLLK GKAVRLKAEDEKGNKLKVPHMGWNRLSFHNESPLLTKTEQGYAYFVHSYYIDGMEENA LLASADYGVRVPAVVGKRNVFGAQFHPEKSSTVGMSILTQFTKMAAEQKVKK*" /label="hisH CDS" gene complement(3099960..3100598) /gene="hisH" /locus_tag="BSU_34890" /old_locus_tag="BSU34890" /label="hisH gene" promotor_no_box 3100456..3100556 /Source="Nicolas_upshift_promotors" /id="U2736" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.973026973026973" /psig="0.000999000999001" /xcortree=24 /SigmaFactorBS="gaaccgactcccggcaaaatgaaagcatcagcttctttcagc tcctccggcttttcagaaacaaaatacggcacgccgacacgttcaagcgcctttgaga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3100516 /Source="Nicolas_upshifts" /id="U2736" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.973026973026973" /psig="0.000999000999001" /xcortree=24 /SigmaFactorBS="gaaccgactcccggcaaaatgaaagcatcagcttctttcagc tcctccggcttttcagaaacaaaatacggcacgccgacacgttcaagcgcctttgaga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3100599..3101183) /gene="hisB" /locus_tag="BSU_34900" /old_locus_tag="BSU34900" /EC_number="4.2.1.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 24311587; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazoleglycerol-phosphate dehydratase [Mn(II)-dependent]" /protein_id="NP_391370.1" /db_xref="EnsemblGenomes-Gn:BSU34900" /db_xref="EnsemblGenomes-Tr:CAB15495" /db_xref="GOA:O34683" /db_xref="InterPro:IPR000807" /db_xref="InterPro:IPR020565" /db_xref="InterPro:IPR020568" /db_xref="SubtiList:BG12598" /db_xref="UniProtKB/Swiss-Prot:O34683" /translation="MRKAERVRKTNETDIELAFTIDGGGQADIKTDVPFMTHMLDLFT KHGQFDLSINAKGDVDIDDHHTTEDIGICLGQALLEALGDKKGIKRYGSAFVPMDEAL AQVVIDLSNRPHLEMRADFPAAKVGTFDTELVHEFLWKLALEARMNLHVIVHYGTNTH HMIEAVFKALGRALDEATTIDPRVKGIPSTKGML*" /label="hisB CDS" gene complement(3100599..3101183) /gene="hisB" /locus_tag="BSU_34900" /old_locus_tag="BSU34900" /label="hisB gene" CDS complement(3101180..3102463) /gene="hisD" /locus_tag="BSU_34910" /old_locus_tag="BSU34910" /EC_number="1.1.1.23" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10353847, 10353848, 21672513, 24140957; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol dehydrogenase" /protein_id="NP_391371.1" /db_xref="EnsemblGenomes-Gn:BSU34910" /db_xref="EnsemblGenomes-Tr:CAB15496" /db_xref="GOA:O34651" /db_xref="InterPro:IPR001692" /db_xref="InterPro:IPR012131" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR022695" /db_xref="SubtiList:BG12599" /db_xref="UniProtKB/Swiss-Prot:O34651" /translation="MKIKTISGAERLSLKRSIDAGTEEQRKTVRSIIEDVKANGDQAV RSYTAKFDCIEIDSPLVTKEEFEEAYTSLDSRLLQVIRQAIENIREYHERQLQSSWFY HRKDGTMLGQKVTALDSAGVYVPGGTAAYPSSVLMNVIPALVAGVERIVLVTPPGKDG LLSPGVLVAAAELGIKDIYKMGGAQAIAALAYGTETIEPVDKITGPGNIYVALAKREV FGDVDIDMIAGPSEIVVLADETAIPSEIAADLLSQAEHDKLSSCVFVTDSMALAETVS AEVNKQLETLPRREIAEASVRDYGCIYVAETMVEAIETVNTLAPEHLEIITQSPEALL GSIKHAGAIFLGRYSPEPVGDYFAGPNHVLPTNGTARFSSPLNVTDFQKKSSIISYSQ SAFEEHAESIAAFARLEGLEAHARSIEARERRISK*" /label="hisD CDS" gene complement(3101180..3102463) /gene="hisD" /locus_tag="BSU_34910" /old_locus_tag="BSU34910" /label="hisD gene" CDS complement(3102460..3103101) /gene="hisG" /locus_tag="BSU_34920" /old_locus_tag="BSU34920" /EC_number="2.4.2.17" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10430882, 12269828, 12511575, 14741209, 15660995, 17154531, 21774583, 22989207, 28092443, 28872824; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP phosphoribosyltransferase" /protein_id="NP_391372.1" /db_xref="EnsemblGenomes-Gn:BSU34920" /db_xref="EnsemblGenomes-Tr:CAB15497" /db_xref="GOA:O34520" /db_xref="InterPro:IPR001348" /db_xref="InterPro:IPR013820" /db_xref="InterPro:IPR018198" /db_xref="InterPro:IPR024893" /db_xref="PDB:2VD2" /db_xref="SubtiList:BG12601" /db_xref="UniProtKB/Swiss-Prot:O34520" /translation="MGKLLTMAMPKGRIFEEAAGLLRQAGYRLPEEFEDSRKLIIDVP EENLRFILAKPMDVTTYVEHGVADVGIAGKDVMLEEERDVYEVLDLNISKCHLAVAGL PNTDWSGVAPRIATKYPNVASSYFREQGEQVEIIKLNGSIELAPLIGLADRIVDIVST GQTLKENGLVETEHICDITSRFIVNPVSYRMKDDVIDEMASRLSLVVEGETAK*" /label="hisG CDS" gene complement(3102460..3103101) /gene="hisG" /locus_tag="BSU_34920" /old_locus_tag="BSU34920" /label="hisG gene" CDS complement(3103094..3104269) /gene="hisZ" /locus_tag="BSU_34930" /old_locus_tag="BSU34930" /EC_number="2.4.2.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10430882, 12269828, 12511575, 15660995; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidyl-tRNA synthetase-like subunit of ATP phophoribosyltransferase" /protein_id="NP_391373.1" /db_xref="EnsemblGenomes-Gn:BSU34930" /db_xref="EnsemblGenomes-Tr:CAB15498" /db_xref="GOA:O34459" /db_xref="InterPro:IPR004516" /db_xref="InterPro:IPR004517" /db_xref="InterPro:IPR006195" /db_xref="SubtiList:BG12606" /db_xref="UniProtKB/Swiss-Prot:O34459" /translation="MFMFEKPHGMRDTLPGLYETKKKVRRSLTDLIDKWGYQFMETPT LEFYDTVGVQSAIEEQQLFKLLDQDGKTLVLRPDMTGPIARVAASKLLKHGHPLRVGY AANVFRAQEREGGRPAEFEQVGVELIGDGTTSADAEVIALVVGALKNAGLASFKIAIG HAGIADALFVEVLGNVERADVLRRFLYEKNYVGYREHVKSLPLSSIDKSRLLELLELR GGIEVCGRAEEIVDSAQGKSVVDELKALWDILEDYGCTENVRLDLNMVSHMSYYTGIL FEVYAENVGFVIGSGGRYNKLLGHFDSPAPATGFGLRIDRLIEALHMKDEPCEIDAVI FSKEQRAQAIAYANEERMKGNKVVLQDLSGIENIDQMTKSFANVTYFIGARKEEQNG* " /label="hisZ CDS" gene complement(3103094..3104269) /gene="hisZ" /locus_tag="BSU_34930" /old_locus_tag="BSU34930" /label="hisZ gene" S_feature complement(3104270..3104347) /Source="Nicolas_S_feature" /locus_tag="new_3589361_3589438_c" /HighExp="Diami, M/G, Etha, BMM, MG 15, MG 10, T-1.10H, T-0.40H, T-1.40H, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1332" promotor_-35 3104313..3104319 /Source="Nicolas_upshift_promotors" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3104331..3104350 /Source="Nicolas_upshift_promotors" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3104331..3104350) /Source="Nicolas_upshift_promotors" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3104344 /Source="Nicolas_upshifts" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3104347) /Source="Nicolas_upshifts" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3104363..3104370) /Source="Nicolas_upshift_promotors" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3104479..3104498 /Source="Nicolas_upshift_promotors" /id="U2739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2160 /SigmaFactorBS="aatcatgaataatgtattaaaggtacgtaatatctcaaattc tttatgtttggCATGCTATAATACAAATCAAatagagaacaaggagataaagatgaaa a" /listShort="yvpB, S1333, pelC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3104486 /Source="Nicolas_upshifts" /id="U2739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2160 /SigmaFactorBS="aatcatgaataatgtattaaaggtacgtaatatctcaaattc tttatgtttggCATGCTATAATACAAATCAAatagagaacaaggagataaagatgaaa a" /listShort="yvpB, S1333, pelC" /GFF_Attribute="listLong" /label="upshifts" CDS 3104520..3105272 /gene="yvpB" /locus_tag="BSU_34940" /old_locus_tag="BSU34940" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydratase" /protein_id="NP_391374.1" /db_xref="EnsemblGenomes-Gn:BSU34940" /db_xref="EnsemblGenomes-Tr:CAB15499" /db_xref="InterPro:IPR016997" /db_xref="SubtiList:BG14130" /db_xref="UniProtKB/Swiss-Prot:O34735" /translation="MKTLRTLCVLMILSGVIFFGLKIDAKDIDIPFLNSLKKVVSDSD TDSAANSKKELKGSAKPLDVILYNQMDAPRLYNGCEVTSLAMVLNYAGYDVTKNTLAN QVATVPLTYSSGLKGDPNDGFVGDMANGPGLGVYHRPIYQLAKTYAGDKVSDLTGKSI SAVYQQLEKGNPVWVITTANFTPVDNMQTWKTPNGTIEITYSEHSVAVTGYDDKYVYL NDPYGYKNRKTDRTSFEKAWKQMGSQAVVIQK*" /label="yvpB CDS" gene 3104520..3105272 /gene="yvpB" /locus_tag="BSU_34940" /old_locus_tag="BSU34940" /label="yvpB gene" S_feature 3105273..3105511 /Source="Nicolas_S_feature" /locus_tag="new_3590364_3590602" /HighExp="LBGstat, LPhT, Cold, Sw, M/G, G180, G135, LBGtran, G150, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1333" promotor_-10 complement(3105294..3105305) /Source="Nicolas_upshift_promotors" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3105300) /Source="Nicolas_upshifts" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3105320..3105326) /Source="Nicolas_upshift_promotors" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3105512..3106177 /gene="pelC" /locus_tag="BSU_34950" /old_locus_tag="BSU34950" /EC_number="4.2.2.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10658655, 15187182, 16514142, 20000851, 24236123" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658655, 15187182, 16514142, 20000851, 24236123; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted pectate (polygalacturonate) lyase" /protein_id="NP_391375.1" /db_xref="EnsemblGenomes-Gn:BSU34950" /db_xref="EnsemblGenomes-Tr:CAB15500" /db_xref="GOA:O34310" /db_xref="InterPro:IPR004898" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG14129" /db_xref="UniProtKB/Swiss-Prot:O34310" /translation="MKKIVSILFMFGLVMGFSQFQPSTVFAADKVVHETIIVPKNTTY DGKGQRFVAGKELGDGSQSENQDPVFRVEDGATLKNVVLGAPAADGVHTYGNVNIQNV KWEDVGEDALTVKKEGKVTIDGGSAQKASDKIFQINKASTFTVKNFTADNGGKFIRQL GGSTFHVDVIIDKCTITNMKEAIFRTDSKTSTVRMTNTRYSNVGQKWIGVQHIYENNN TQF*" /label="pelC CDS" gene 3105512..3106177 /gene="pelC" /locus_tag="BSU_34950" /old_locus_tag="BSU34950" /label="pelC gene" downshifts 3106148 /Source="Nicolas_upshifts" /id="D1809" /incds=0 /nref=85 /ntot=213 /MaxReadThrough="1.40389" /MaxDrop="4.93342" /score="16.0973385" /energy="-14.9" /TU="NA" /idTUdmin="U2739" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS complement(3106197..3106715) /gene="hprF" /locus_tag="BSU_34960" /old_locus_tag="BSU34960" /EC_number="2.3.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:21761520, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21761520, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dephosphorylated heptaprenylglyceryl phosphate O-acetyltransferase" /protein_id="NP_391376.1" /db_xref="EnsemblGenomes-Gn:BSU34960" /db_xref="EnsemblGenomes-Tr:CAB15501" /db_xref="GOA:O34993" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="SubtiList:BG14128" /db_xref="UniProtKB/Swiss-Prot:O34993" /translation="MRKTDRHPVSGANSLWHVYQTVPFLKVVKNFIVIQIARYTPFIG MKNWLYRTFLRMKVGKQTSFALMVMPDIMFPEKISVGTNTIIGYNTTILAHEYLIHEY RIGKVLIGDEVMIGANTTILPGVKIGDGAVVSAGTLVHKDVPDGAFVGGNPMRIIYTK EEMQERLKKSAE*" /label="hprF CDS" gene complement(3106197..3106715) /gene="hprF" /locus_tag="BSU_34960" /old_locus_tag="BSU34960" /label="hprF gene" downshifts complement(3106231) /Source="Nicolas_upshifts" /id="D1810" /incds=0 /nref=245 /ntot=283 /MaxReadThrough="1.27998" /MaxDrop="6.44997" /score="38.2106579" /energy="-14.9" /TU="NA" /idTUdmin="U2741" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(3106719..3107369) /gene="ppaX" /locus_tag="BSU_34970" /old_locus_tag="BSU34970" /EC_number="3.6.1.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9465101, 12359880, 12411438, 16182622, 22353596" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9465101, 12359880, 12411438, 16182622, 22353596; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Hpr-associated pyrophosphatase" /protein_id="NP_391377.1" /db_xref="EnsemblGenomes-Gn:BSU34970" /db_xref="EnsemblGenomes-Tr:CAB15502" /db_xref="GOA:Q9JMQ2" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023733" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG14127" /db_xref="UniProtKB/Swiss-Prot:Q9JMQ2" /translation="MSDKQVTTILFDLDGTLINTNELIIASFLHTLEHYYPSKYKRED VLAFIGPSLFDTFSSMDPDKCEDMIAMYRAYNHDMHDSLVTEYETVYETLDALKKAGF TLGIVTTKLRDTVNMGLKLTGIGEFFETVVTLDDVTNAKPDPEPVLLALKQLGSEPAE AIMVGDNYHDVLAGKNAGTKTAGVAWTIKGPEMLAKHEPDFMLEKMSDLLQIVGVK*" /label="ppaX CDS" gene complement(3106719..3107369) /gene="ppaX" /locus_tag="BSU_34970" /old_locus_tag="BSU34970" /label="ppaX gene" CDS complement(3107366..3108304) /gene="yvoD" /locus_tag="BSU_34980" /old_locus_tag="BSU34980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 27226549; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein with nucleotide binding domain" /protein_id="NP_391378.1" /db_xref="EnsemblGenomes-Gn:BSU34980" /db_xref="EnsemblGenomes-Tr:CAB15503" /db_xref="GOA:O34382" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG14126" /db_xref="UniProtKB/Swiss-Prot:O34382" /translation="MKKIFLAGLAAGFQTTWTLGKVIFPVTLLVTLLQHTPVMDWLVR LITPVMGLFGLSGEAAIPLVLGNMLNLYAGIAGILTLDLSVKEVFILAVMLSFCHNLI IESTVAAKVGIRIGVILAVRIGLAAVSAIVINLIWHGGKETAQYGFIAAKSAAPDSWL GMLAEALTKAGLGVLQLAAIVIPLMIIIQFLRDLGWLYRFSRWLSPFTQLLGMNKNTS MTMVTGLTIGLAYGAGVMIKAVEDDGVSKRDMTLAFIFLVACHAVVEDTLVFIPLGIP VWPLLLIRVTTAVLLTMAIAHTWKKWKPSAVGKEAI*" /label="yvoD CDS" gene complement(3107366..3108304) /gene="yvoD" /locus_tag="BSU_34980" /old_locus_tag="BSU34980" /label="yvoD gene" CDS complement(3108328..3109137) /gene="lgt" /locus_tag="BSU_34990" /old_locus_tag="BSU34990" /EC_number="2.4.99.-" /function="16.5: Explore" /function="16.13: Shape" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10096076, 11425480, 15126458, 15849754, 16850406, 18556788, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10096076, 11425480, 15126458, 15849754, 16850406, 18556788, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prelipoprotein diacylglycerol transferase" /protein_id="NP_391379.1" /db_xref="EnsemblGenomes-Gn:BSU34990" /db_xref="EnsemblGenomes-Tr:CAB15504" /db_xref="GOA:O34752" /db_xref="InterPro:IPR001640" /db_xref="SubtiList:BG12611" /db_xref="UniProtKB/Swiss-Prot:O34752" /translation="MNEAIEPLNPIAFQLGPLAVHWYGIIIGLGALLGLWIAMRESEK RGLQKDTFIDLVLFAIPIAIICARIYYVAFEWDYYAAHPGEIIKIWKGGIAIHGGLIG AILTGYVFSRVKNLSFWKLADIAAPSILLGQAIGRWGNFMNQEAHGEAVSRAFLENLH LPEFIINQMYINGQYYHPTFLYESLWSFVGVIVLLLLRRANLRRGEMFLIYIIWYSIG RYFIEGMRTDSLMLTDSLRIAQVISIVLIVLAVAAIIFRRVKGYSKERYAE*" /label="lgt CDS" gene complement(3108328..3109137) /gene="lgt" /locus_tag="BSU_34990" /old_locus_tag="BSU34990" /label="lgt gene" CDS complement(3109151..3110083) /gene="hprK" /locus_tag="BSU_35000" /old_locus_tag="BSU35000" /EC_number="2.7.4.-" /EC_number="2.7.11.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10636874, 12009882, 12359875, 12411438, 12779331, 15023355, 16267306, 17878158, 20487301, 21992469, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10636874, 12009882, 12359875, 12411438, 12779331, 15023355, 16267306, 17878158, 20487301, 21992469, 27226549; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="serine/threonine protein kinase/phosphorylase (pyrophosphate-producing)" /protein_id="NP_391380.1" /db_xref="EnsemblGenomes-Gn:BSU35000" /db_xref="EnsemblGenomes-Tr:CAB15505" /db_xref="GOA:O34483" /db_xref="InterPro:IPR003755" /db_xref="InterPro:IPR011104" /db_xref="InterPro:IPR011126" /db_xref="InterPro:IPR028979" /db_xref="SubtiList:BG14125" /db_xref="UniProtKB/Swiss-Prot:O34483" /translation="MAKVRTKDVMEQFNLELISGEEGINRPITMSDLSRPGIEIAGYF TYYPRERVQLLGKTELSFFEQLPEEEKKQRMDSLCTDVTPAIILSRDMPIPQELIDAS EKNGVPVLRSPLKTTRLSSRLTNFLESRLAPTTAIHGVLVDIYGVGVLITGKSGVGKS ETALELVKRGHRLVADDCVEIRQEDQDTLVGNAPELIEHLLEIRGLGIINVMTLFGAG AVRSNKRITIVMNLELWEQGKQYDRLGLEEETMKIIDTEITKLTIPVRPGRNLAVIIE VAAMNFRLKRMGLNAAEQFTNKLADVIEDGEQEE*" /label="hprK CDS" gene complement(3109151..3110083) /gene="hprK" /locus_tag="BSU_35000" /old_locus_tag="BSU35000" /label="hprK gene" promotor_-10 complement(3110125..3110144) /Source="Nicolas_upshift_promotors" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3110131) /Source="Nicolas_upshifts" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3110160..3110165) /Source="Nicolas_upshift_promotors" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3110200..3110207 /Source="Nicolas_upshift_promotors" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3110219 /Source="Nicolas_upshifts" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3110222..3110239 /Source="Nicolas_upshift_promotors" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3110265..3111455 /gene="nagA" /locus_tag="BSU_35010" /old_locus_tag="BSU35010" /EC_number="3.5.1.25" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6774970, 14557261, 21602348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6774970, 14557261, 21602348; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglucosamine-6-phosphate deacetylase" /protein_id="NP_391381.1" /db_xref="EnsemblGenomes-Gn:BSU35010" /db_xref="EnsemblGenomes-Tr:CAB15506" /db_xref="GOA:O34450" /db_xref="InterPro:IPR003764" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="PDB:2VHL" /db_xref="SubtiList:BG12630" /db_xref="UniProtKB/Swiss-Prot:O34450" /translation="MAESLLIKDIAIVTENEVIKNGYVGINDGKISTVSTERPKEPYS KEIQAPADSVLLPGMIDIHIHGGYGADTMDASFSTLDIMSSRLPEEGTTSFLATTITQ EHGNISQALVNAREWKAAEESSLLGAELLGIHLEGPFVSPKRAGAQPKEWIRPSDVEL FKKWQQEAGGLIKIVTLAPEEDQHFELIRHLKDESIIASMGHTDADSALLSDAAKAGA SHMTHLYNAMSPFHHREPGVIGTALAHDGFVTELIADGIHSHPLAAKLAFLAKGSSKL ILITDSMRAKGLKDGVYEFGGQSVTVRGRTALLSDGTLAGSILKMNEGARHMREFTNC SWTDIANITSENAAKQLGIFDRKGSVTVGKDADLVIVSSDCEVILTICRGNIAFISKE ADQI*" /label="nagA CDS" gene 3110265..3111455 /gene="nagA" /locus_tag="BSU_35010" /old_locus_tag="BSU35010" /label="nagA gene" promotor_-35 3111253..3111259 /Source="Nicolas_upshift_promotors" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3111274 /Source="Nicolas_upshifts" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3111275..3111293 /Source="Nicolas_upshift_promotors" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3111452..3112180 /gene="nagBA" /locus_tag="BSU_35020" /old_locus_tag="BSU35020" /EC_number="3.5.99.6" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15755726, 18436239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15755726, 18436239; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucosamine-6-phosphate isomerase" /protein_id="NP_391382.1" /db_xref="EnsemblGenomes-Gn:BSU35020" /db_xref="EnsemblGenomes-Tr:CAB15507" /db_xref="GOA:O35000" /db_xref="InterPro:IPR004547" /db_xref="InterPro:IPR006148" /db_xref="InterPro:IPR018321" /db_xref="PDB:2BKV" /db_xref="PDB:2BKX" /db_xref="SubtiList:BG12631" /db_xref="UniProtKB/Swiss-Prot:O35000" /translation="MKVMECQTYEELSQIAARITADTIKEKPDAVLGLATGGTPEGTY RQLIRLHQTENLSFQNITTVNLDEYAGLSSDDPNSYHFYMNDRFFQHIDSKPSRHFIP NGNADDLEAECRRYEQLVDSLGDTDIQLLGIGRNGHIGFNEPGTSFKSRTHVVTLNEQ TRQANARYFPSIDSVPKKALTMGIQTILSSKRILLLISGKSKAEAVRKLLEGNISEDF PASALHLHSDVTVLIDREAASLRP*" /label="nagBA CDS" gene 3111452..3112180 /gene="nagBA" /locus_tag="BSU_35020" /old_locus_tag="BSU35020" /label="nagBA gene" CDS 3112198..3112929 /gene="nagR" /locus_tag="BSU_35030" /old_locus_tag="BSU35030" /experiment="publication(s) with functional evidences, PMID:16207374, 20047956, 21602348, 23667565, 24673833, 26162881" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374, 20047956, 21602348, 23667565, 24673833, 26162881; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family)" /protein_id="NP_391383.1" /db_xref="EnsemblGenomes-Gn:BSU35030" /db_xref="EnsemblGenomes-Tr:CAB15508" /db_xref="GOA:O34817" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2WV0" /db_xref="PDB:4U0V" /db_xref="PDB:4U0W" /db_xref="PDB:4U0Y" /db_xref="PDB:4WWC" /db_xref="SubtiList:BG14124" /db_xref="UniProtKB/Swiss-Prot:O34817" /translation="MNINKQSPIPIYYQIMEQLKTQIKNGELQPDMPLPSEREYAEQF GISRMTVRQALSNLVNEGLLYRLKGRGTFVSKPKMEQALQGLTSFTEDMKSRGMTPGS RLIDYQLIDSTEELAAILGCGHPSSIHKITRVRLANDIPMAIESSHIPFELAGELNES HFQSSIYDHIERYNSIPISRAKQELEPSAATTEEANILGIQKGAPVLLIKRTTYLQNG TAFEHAKSVYRGDRYTFVHYMDRLS*" /label="nagR CDS" gene 3112198..3112929 /gene="nagR" /locus_tag="BSU_35030" /old_locus_tag="BSU35030" /label="nagR gene" CDS complement(3112949..3116818) /gene="yvnB" /locus_tag="BSU_35040" /old_locus_tag="BSU35040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported hydrolase" /protein_id="NP_391384.1" /db_xref="EnsemblGenomes-Gn:BSU35040" /db_xref="EnsemblGenomes-Tr:CAB15509" /db_xref="GOA:O34986" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR011401" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036415" /db_xref="SubtiList:BG14123" /db_xref="UniProtKB/Swiss-Prot:O34986" /translation="MRKYTVIASILLSFLSVLSGGHHESKAFPVVQQELFQTPHYIPL LENPPQIDVKAEMRSNLMIEAQVRDNSYQAFSAFLFYKQSNELGYKMVPMDPTPGAVR KFLAQIPKRLIWNSELEYYIVMSNGKQRVESETKKLKLEGYQADLAHIPELLITELAV DTKNIGRADGYEFIEIFNTTDRTIDFKDYHIRYRYPKEGPDSDLIWRPDERILIPSGE TFVVWLKPAGHPELTSADFNRYYQTQLKEGKNLAVIDETEGMANTRPRAVVISTNTGK DISVAHYRKHALRRLSSVLYKYPLNGTAELLNISIGEKNPSPGTVLQAQVPDQKRKIK LDKEKPVIEDLTDRKPVRPAESIELRADIRDRSLVKTVAFYYRTDENKPFKRILAEKD RNDNLFHYIVYSPELIGKDQLEYYVAAGDGINEARTPVKMIDIKQTSKAHGLRMNIEN RDTLSGTQFLKATTEGRADSIKLWIDGKKQVTEPAMEKEVYFAFDTRKTNLYFKNAVT MEGKVLKVFDDTTNKYRTYSVPLPETLLRKGKQLQRITIRSGSKVSPFDTAENRDDFL VKNARLVLSDGTVIRDQRVSPEKELFIGDNQRSNKSWQFQFNLPDGLFTSQLLEWDTS KLSEGAHHIQASDGKENVSLVVRVDNSGPHIEPNITEGQTYKGNLILQADMYDKWSRI EEAEASLDGESITLPYHTSSSDLLPGKHSLKVTATDLAGNKTVIERIFKTEREHPDQP EVIDSEADTHKAKLSVRVKDPTNDAMDVGFYRGFQYTARNHVKIFKHASLTEPPKSFV PERETPFTNKELERVSAADGKTVSTENKELFPYHRFEVTVDPSIDENDLAESVWKGSS LPGRKVTMYAWNYRTNEWQPVDSFVAKDDKPFTLKASVIAADFVRESKMNVIVQDEIP PAKDMYTFVWMSDTQYYAESYPHIFDKQTEWIKDNQKQLNIKYVFHTGDIVDDSADIR QWKNADRSMSVLDKSGIPYGVLAGNHDVGHKDGSYRAFGKYFGSDRFDKKFHYGGSYK NNRGHYDLISSNGNDYIMLYMGWGITDEDIAWMNQVLKKHPDRMAILAFHEYLLVSGN RSPIGEKIFKEIVKPNPNVVMVLSGHYHSAMRKTDELDDDGDGKPDRLVHQMLADYQG GPEGGQGYLRLLQFDQANDMVHVSTYSPYVKDKNYYDTDTYGNKDEFSLSLDLKPRIK KVETDYFECNVYTNEELGKREQVKSGDTAEFRWDHLEPQSVYYWYIIVEDSFNGKTKS PIWKFKTKKETYRPAPDQFDFRHVSNP*" /label="yvnB CDS" gene complement(3112949..3116818) /gene="yvnB" /locus_tag="BSU_35040" /old_locus_tag="BSU35040" /label="yvnB gene" downshifts complement(3113071) /Source="Nicolas_upshifts" /id="D1811" /incds=1 /nref=19 /ntot=109 /MaxReadThrough="1.28942" /MaxDrop="4.39575" /score="28.0438848" /energy="-16.5" /TU="NA" /idTUdmin="U2744" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3116838..3116849) /Source="Nicolas_upshift_promotors" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3116845) /Source="Nicolas_upshifts" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3116864..3116870) /Source="Nicolas_upshift_promotors" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3116908..3116914 /Source="Nicolas_upshift_promotors" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3116928..3116947 /Source="Nicolas_upshift_promotors" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3116933 /Source="Nicolas_upshifts" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="upshifts" CDS 3116983..3117456 /gene="yvnA" /locus_tag="BSU_35050" /old_locus_tag="BSU35050" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391385.1" /db_xref="EnsemblGenomes-Gn:BSU35050" /db_xref="EnsemblGenomes-Tr:CAB15510" /db_xref="GOA:O34692" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14122" /db_xref="UniProtKB/Swiss-Prot:O34692" /translation="MDNSIHDELFQAIQQFALKRDKRVWQKVQIPSIGISSQHHDHLK KDWTLTQLHIVSCIHTSQNVNNSFLASRLHISKAAVSKAVHALLKHNIITVTKKPGNK KEIFYTLTDSGRKLAALHEQLHEKAKEQYKQLFNEFSIDDLKTVTAFFNLWIKYM*" /label="yvnA CDS" gene 3116983..3117456 /gene="yvnA" /locus_tag="BSU_35050" /old_locus_tag="BSU35050" /label="yvnA gene" S_feature 3117457..3117564 /Source="Nicolas_S_feature" /locus_tag="new_3602548_3602655" /HighExp="T5.0H, T4.0H, T3.30H, T3.0H, T2.30H, M9-stat, T2.0H, T1.30H, T1.0H, BC" /AntisenseName="cypX" /AntisenseCor="-1.1473096183385199E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1334" CDS complement(3117497..3118714) /gene="cypX" /locus_tag="BSU_35060" /old_locus_tag="BSU35060" /EC_number="1.14.-.-" /function="16.5: Explore" /function="16.14: Store" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:4204912, 20690619, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204912, 20690619, 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclo-L-leucyl-L-leucyl dipeptide oxidase, pulcheriminic synthase" /protein_id="NP_391386.1" /db_xref="EnsemblGenomes-Gn:BSU35060" /db_xref="EnsemblGenomes-Tr:CAB15511" /db_xref="GOA:O34926" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR030904" /db_xref="InterPro:IPR036396" /db_xref="PDB:3NC3" /db_xref="PDB:3NC5" /db_xref="PDB:3NC6" /db_xref="PDB:3NC7" /db_xref="SubtiList:BG12580" /db_xref="UniProtKB/Swiss-Prot:O34926" /translation="MSQSIKLFSVLSDQFQNNPYAYFSQLREEDPVHYEESIDSYFIS RYHDVRYILQHPDIFTTKSLVERAEPVMRGPVLAQMHGKEHSAKRRIVVRSFIGDALD HLSPLIKQNAENLLAPYLERGKSDLVNDFGKTFAVCVTMDMLGLDKRDHEKISEWHSG VADFITSISQSPEARAHSLWCSEQLSQYLMPVIKERRVNPGSDLISILCTSEYEGMAL SDKDILALILNVLLAATEPADKTLALMIYHLLNNPEQMNDVLADRSLVPRAIAETLRY KPPVQLIPRQLSQDTVVGGMEIKKDTIVFCMIGAANRDPEAFEQPDVFNIHREDLGIK SAFSGAARHLAFGSGIHNCVGAAFAKNEIEIVANIVLDKMRNIRLEEDFCYAESGLYT RGPVSLLVAFDGA*" /label="cypX CDS" gene complement(3117497..3118714) /gene="cypX" /locus_tag="BSU_35060" /old_locus_tag="BSU35060" /label="cypX gene" downshifts complement(3117510) /Source="Nicolas_upshifts" /id="D1812" /incds=0 /nref=11 /ntot=50 /MaxReadThrough="2.27112" /MaxDrop="6.67384" /score="-0.264310319" /energy="-11.6" /TU="NA" /idTUdmin="U2747" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3117536..3117541 /Source="Nicolas_upshift_promotors" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3117556..3117567 /Source="Nicolas_upshift_promotors" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3117566..3117851 /Source="Nicolas_S_feature" /locus_tag="new_3602657_3602942" /HighExp="BC, Sw, Lbstat, T5.0H, M9-stat, T4.0H, T3.30H, B60, T1.30H, T0.30H" /AntisenseName="cypX" /AntisenseCor="-4.04991056466339E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.438, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1335" upshifts 3117566 /Source="Nicolas_upshifts" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="upshifts" downshifts 3117808 /Source="Nicolas_upshifts" /id="D1813" /incds=1 /nref=9 /ntot=165 /MaxReadThrough="3.27492" /MaxDrop="3.99509" /score="54.0406126" /energy="-11.4" /TU="U2745,U2746" /idTUdmin="U2746" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(3118730..3119476) /gene="pchC" /locus_tag="BSU_35070" /old_locus_tag="BSU35070" /EC_number="6.-.-.-" /function="16.14: Store" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:4204912, 19430487, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204912, 19430487, 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclodipeptide synthase (tRNA-dependent), pulcherimminic acid precursor" /protein_id="NP_391387.1" /db_xref="EnsemblGenomes-Gn:BSU35070" /db_xref="EnsemblGenomes-Tr:CAB15512" /db_xref="GOA:O34351" /db_xref="InterPro:IPR030903" /db_xref="SubtiList:BG14121" /db_xref="UniProtKB/Swiss-Prot:O34351" /translation="MTGMVTERRSVHFIAEALTENCREIFERRRHVLVGISPFNSRFS EDYIYRLIGWAKAQFKSVSVLLAGHEAANLLEALGTPRGKAERKVRKEVSRNRRFAER ALVAHGGDPKAIHTFSDFIDNKAYQLLRQEVEHAFFEQPHFRHACLDMSREAIIGRAR GVSLMMEEVSEDMLNLAVEYVIAELPFFIGAPDILEVEETLLAYHRPWKLGEKISNHE FSICMRPNQGYLIVQEMAQMLSEKRITSEG*" /label="pchC CDS" gene complement(3118730..3119476) /gene="pchC" /locus_tag="BSU_35070" /old_locus_tag="BSU35070" /label="pchC gene" S_feature complement(3119477..3119663) /Source="Nicolas_S_feature" /locus_tag="new_3604568_3604754_c" /HighExp="LBGstat, T1.30H, T2.0H, T2.30H, T3.0H, T1.0H, B36, BT, T3.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1336" promotor_-10 complement(3119649..3119668) /Source="Nicolas_upshift_promotors" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3119663) /Source="Nicolas_upshifts" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3119682..3119689) /Source="Nicolas_upshift_promotors" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3119797..3119804 /Source="Nicolas_upshift_promotors" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3119819..3119838 /Source="Nicolas_upshift_promotors" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3119831 /Source="Nicolas_upshifts" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="upshifts" S_feature 3119832..3119901 /Source="Nicolas_S_feature" /locus_tag="new_3604923_3604992" /HighExp="LBGstat, T1.30H, T2.0H, T2.30H, T1.0H, T0.30H, B36, T3.0H, BT, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1337" CDS 3119902..3120411 /gene="pchR" /locus_tag="BSU_35080" /old_locus_tag="BSU35080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27542896; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for pulcherriminic acid synthesis" /protein_id="NP_391388.1" /db_xref="EnsemblGenomes-Gn:BSU35080" /db_xref="EnsemblGenomes-Tr:CAB15513" /db_xref="GOA:P40762" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11018" /db_xref="UniProtKB/Swiss-Prot:P40762" /translation="MSDLTKQMIYDIYVRLLHLNEQKANTSLQQFFKEAAEEDVAEIP KNMTSIHVIDCIGQHEPINNAGIARKMNLSKANVTKISTKLIKEEFINSYQLTDNKKE VYFKLTRKGRRIFDLHEKLHKKKELAFYQFLDSFSQEEQKAVLKFLEQLTSTLEAEQT DGTPDKPVK*" /label="pchR CDS" gene 3119902..3120411 /gene="pchR" /locus_tag="BSU_35080" /old_locus_tag="BSU35080" /label="pchR gene" S_feature complement(3120307..3121645) /Source="Nicolas_S_feature" /locus_tag="new_3605398_3606736_c" /HighExp="T0.30H, T1.0H, T1.30H, T-0.40H, T0.0H, T2.0H, G135, T2.30H, T-1.10H, G180" /AntisenseName="yvmA" /AntisenseCor="0.2423954904641" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1338" downshifts complement(3120348) /Source="Nicolas_upshifts" /id="D1814" /incds=1 /nref=1 /ntot=66 /MaxReadThrough="1.42525" /MaxDrop="2.72496" /score="14.1278884" /energy="-7.8" /TU="NA" /idTUdmin="U2749" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3120432..3121643 /gene="pchE" /locus_tag="BSU_35090" /old_locus_tag="BSU35090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 27542896; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pulcherriminic acid efflux transporter" /protein_id="NP_391389.1" /db_xref="EnsemblGenomes-Gn:BSU35090" /db_xref="EnsemblGenomes-Tr:CAB15514" /db_xref="GOA:O34307" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14120" /db_xref="UniProtKB/Swiss-Prot:O34307" /translation="MAHTKSKAVLILYTVCFSAFFASLSQNIYSPILPIIKESFHVST AMVNLSVSVFMIVTAIMQIILGAIIDFKGARIVLITGILATAAASIGCAVTTDFTLFL IFRMIQAAGSAALPLIAATTIGQLFTGNERGSAMGTYQMLLSVAPAIAPVLGGFIGGA AGYEGIFWILAAISIVLLVTNSITFPKDSPTESMQQAKGNVFAHYKSIFTNRTGNVIL TLSFVLFFIYFAVIVYLPILLTEHYHIDVGIAGLLYLPLALSTIAGTFLFKRIQAKIG LHTLFIGSNVIAACSIILFAVTHSVSLVLMALTLALFGISMGVIPPLYSTMITNEFEH NRGSAIGMFNFIRYTGMAAGPMVSAYLLTMMPSAMSFSLLGLGFAALSFCLLPPMFSP QKRTKQKKHHM*" /label="pchE CDS" gene 3120432..3121643 /gene="pchE" /locus_tag="BSU_35090" /old_locus_tag="BSU35090" /label="pchE gene" downshifts 3121641 /Source="Nicolas_upshifts" /id="D1815" /incds=0 /nref=33 /ntot=196 /MaxReadThrough="5.27186" /MaxDrop="4.73361" /score="54.0406126" /energy="-11.4" /TU="U2748" /idTUdmin="U2748" /TUdmin="-721" /isTUend="FALSE" /label="downshifts" CDS complement(3121671..3122030) /gene="yvlD" /locus_tag="BSU_35100" /old_locus_tag="BSU35100" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26296725; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral phage holin-like membrane protein" /protein_id="NP_391390.1" /db_xref="EnsemblGenomes-Gn:BSU35100" /db_xref="EnsemblGenomes-Tr:CAB15515" /db_xref="GOA:O34648" /db_xref="InterPro:IPR007165" /db_xref="SubtiList:BG14119" /db_xref="UniProtKB/Swiss-Prot:O34648" /translation="MVKWAVSILVNALLLIVIDGYIDSIHISSIGAAIIASLILSILN VLIKPLLIIFTLPVTMVTLGLFLFVINAITLMMTASIMGDSFQIDGFGTAIWASVILS VFHLLIQKGILEPLRKK*" /label="yvlD CDS" gene complement(3121671..3122030) /gene="yvlD" /locus_tag="BSU_35100" /old_locus_tag="BSU35100" /label="yvlD gene" S_feature 3121686..3122402 /Source="Nicolas_S_feature" /locus_tag="new_3606777_3607493" /HighExp="LBGstat, S8, Gly, C30, G135, S7, C90, Sw, Fru, S6" /AntisenseName="yvlC" /AntisenseCor="0.178445666283919" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1339" downshifts complement(3121690) /Source="Nicolas_upshifts" /id="D1816" /incds=0 /nref=129 /ntot=265 /MaxReadThrough="4.63835" /MaxDrop="5.15146" /score="14.4434545" /energy="-9.6" /TU="U2749" /idTUdmin="U2751" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3122032..3122229) /gene="yvlC" /locus_tag="BSU_35110" /old_locus_tag="BSU35110" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 23980836; Product type r : regulator" /codon_start=1 /transl_table=11 /product="membrane associated phage-like stress regulator,nisin resistance" /protein_id="NP_391391.1" /db_xref="EnsemblGenomes-Gn:BSU35110" /db_xref="EnsemblGenomes-Tr:CAB15516" /db_xref="GOA:O34719" /db_xref="InterPro:IPR007168" /db_xref="SubtiList:BG14118" /db_xref="UniProtKB/Swiss-Prot:O34719" /translation="MNKLYRSEKNKKIAGVIGGLAEYFNWDASLLRVITVILAIMTSV LPVLLIYIIWIFIVPSERDMK*" /label="yvlC CDS" gene complement(3122032..3122229) /gene="yvlC" /locus_tag="BSU_35110" /old_locus_tag="BSU35110" /label="yvlC gene" CDS complement(3122234..3123331) /gene="yvlB" /locus_tag="BSU_35120" /old_locus_tag="BSU35120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23980836" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function, stress-related" /protein_id="NP_391392.1" /db_xref="EnsemblGenomes-Gn:BSU35120" /db_xref="EnsemblGenomes-Tr:CAB15517" /db_xref="InterPro:IPR016599" /db_xref="InterPro:IPR025164" /db_xref="SubtiList:BG14117" /db_xref="UniProtKB/Swiss-Prot:O34628" /translation="MKQEKERILKLVEEGKLTAQEALTLIEKLDSDYKEKEEKITALS VHVHDEEEPFTTAKKESGKPSLGAKLFDWIDSAVKKVKEVDLDLNFGHAYDVQHIFQF KDTDFSSVELQIANGSVNIVPWEDDDIRAECQAKVYRADSQDAARHAFLQHIECEIKG NKFFIRTEKKTMKTNVTLYIPQKEYDKIRVKLFNGPVRGEHLHVKEFSAKTTNGVLSF SYLTAEKAIAETANGQIKLASHSCGTIEAETINGLIDLRGKSESIDVQSFNGNIAINV TESDCRSIYAKTTTGNVELAIPDDLAVKAELKSNLGTLSHELMDVEMLKEKNDTIQKE MMFTSNQAHDQNITVFSESLTGAIKLKYSQR*" /label="yvlB CDS" gene complement(3122234..3123331) /gene="yvlB" /locus_tag="BSU_35120" /old_locus_tag="BSU35120" /label="yvlB gene" CDS complement(3123356..3123682) /gene="yvlA" /locus_tag="BSU_35130" /old_locus_tag="BSU35130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23980836" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391393.1" /db_xref="EnsemblGenomes-Gn:BSU35130" /db_xref="EnsemblGenomes-Tr:CAB15518" /db_xref="GOA:O34322" /db_xref="SubtiList:BG14116" /db_xref="UniProtKB/Swiss-Prot:O34322" /translation="MNRNQAIIASLCYFSVFIAPIIVPIVAYFVVNEKETKRHAIRSL ISHIVPFVGWLFLFIALLGGAVAIDGDSLLPVFVIIGGAVIYFLVVIGIIIWNVIQGI KVLRAA*" /label="yvlA CDS" gene complement(3123356..3123682) /gene="yvlA" /locus_tag="BSU_35130" /old_locus_tag="BSU35130" /label="yvlA gene" promotor_-10 complement(3123735..3123750) /Source="Nicolas_upshift_promotors" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3123750) /Source="Nicolas_upshifts" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3123752..3124242) /Source="Nicolas_S_feature" /locus_tag="new_3608843_3609333_c" /HighExp="H2O2, G180, Paraq, G150, G135, dia15, Oxctl, Diami, Lbexp, LBGexp" /AntisenseName="yvkN" /AntisenseCor="0.37678416921083902" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1340" promotor_-35 complement(3123762..3123771) /Source="Nicolas_upshift_promotors" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3123830..3123833 /Source="Nicolas_upshift_promotors" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3123848..3123867 /Source="Nicolas_upshift_promotors" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3123858 /Source="Nicolas_upshifts" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="upshifts" CDS 3123900..3124130 /gene="yvkN" /locus_tag="BSU_35140" /old_locus_tag="BSU35140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391394.1" /db_xref="EnsemblGenomes-Gn:BSU35140" /db_xref="EnsemblGenomes-Tr:CAB15519" /db_xref="SubtiList:BG14115" /db_xref="UniProtKB/Swiss-Prot:O34604" /translation="MEKDPSDYTVTQESVLKLIQEQKRMNREMITELEQIHGPFPISH DIQYIKVLLDSSNTHIVQDLMSVSKQLYKKTL*" /label="yvkN CDS" gene 3123900..3124130 /gene="yvkN" /locus_tag="BSU_35140" /old_locus_tag="BSU35140" /label="yvkN gene" promotor_-10 complement(3124233..3124252) /Source="Nicolas_upshift_promotors" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="promotor_-10" upshifts complement(3124243) /Source="Nicolas_upshifts" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="upshifts" promotor_-35 complement(3124268..3124272) /Source="Nicolas_upshift_promotors" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="promotor_-35" CDS complement(3124329..3124811) /gene="yvzB" /locus_tag="BSU_35150" /old_locus_tag="BSU35150" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16936039; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="putative flagellin" /db_xref="EnsemblGenomes-Gn:BSU35150" /db_xref="EnsemblGenomes-Tr:CAB15520" /db_xref="GOA:O34366" /db_xref="InterPro:IPR001029" /db_xref="PSEUDO:CAB15520.1" /db_xref="SubtiList:BG14158" /db_xref="UniProtKB/Swiss-Prot:O34366" /translation="MDALIEEVDGISNRTEFNGKKLLDGTETDGFTFQIGANAGQQLT VNIDSMSSTALGVNALNVTDFANTPFDTQLESIDTAINNVSNQRAKLGAVQNRLEHTI NNLGASSENLTAAESRIRDVDMAKEMSEFTKNNIPSQASQAMLAQANQQPQNVLQLLR *" /label="yvzB CDS" gene complement(3124329..3124811) /gene="yvzB" /locus_tag="BSU_35150" /old_locus_tag="BSU35150" /pseudo /label="yvzB gene" downshifts 3124337 /Source="Nicolas_upshifts" /id="D1817" /incds=0 /nref=13 /ntot=113 /MaxReadThrough="0.9814" /MaxDrop="4.76969" /score="2.6592903" /energy="-5.7" /TU="NA" /idTUdmin="U2750" /TUdmin=17 /isTUend="TRUE" /label="downshifts" downshifts complement(3124352) /Source="Nicolas_upshifts" /id="D1818" /incds=0 /nref=118 /ntot=206 /MaxReadThrough="2.62918" /MaxDrop="8.97968" /score="25.6132739" /energy="-19.8" /TU="NA" /idTUdmin="U2752" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(3124484) /Source="Nicolas_upshifts" /id="U2752" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96003996003996" /psig="0.011988011988012" /xcortree=15 /SigmaFactorBS="aaacttggtgcggtacaaaaccgtctagagcacacaatcaac aaccttgGTGCttcttctgaaaacctgacagctgctgagtcccgtatccgtgacgttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3124492..3124495) /Source="Nicolas_upshift_promotors" /id="U2752" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96003996003996" /psig="0.011988011988012" /xcortree=15 /SigmaFactorBS="aaacttggtgcggtacaaaaccgtctagagcacacaatcaac aaccttgGTGCttcttctgaaaacctgacagctgctgagtcccgtatccgtgacgttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3124572..3124576) /Source="Nicolas_upshift_promotors" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3124572) /Source="Nicolas_upshifts" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3124592..3124595) /Source="Nicolas_upshift_promotors" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3124812..3124945) /Source="Nicolas_S_feature" /locus_tag="new_3609903_3610036_c" /HighExp="H2O2, Sw, M40t45, M40t90, Diami, Salt, dia15, BC, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1341" CDS complement(3124973..3127846) /gene="uvrA" /locus_tag="BSU_35160" /old_locus_tag="BSU35160" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751826, 16267290, 16426634, 25713353, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751826, 16267290, 16426634, 25713353, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit A)" /protein_id="NP_391396.1" /db_xref="EnsemblGenomes-Gn:BSU35160" /db_xref="EnsemblGenomes-Tr:CAB15533" /db_xref="GOA:O34863" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004602" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12697" /db_xref="UniProtKB/Swiss-Prot:O34863" /translation="MAMDRIEVKGARAHNLKNIDVTIPRDQLVVVTGLSGSGKSSLAF DTIYAEGQRRYVESLSAYARQFLGQMDKPDVDAIEGLSPAISIDQKTTSRNPRSTVGT VTEIYDYLRLLYARVGKPHCPEHGIEITSQTIEQMVDRILEYPERTKLQVLAPIVSGR KGAHVKVLEQIRKQGYVRVRIDGEMAELSDDIELEKNKKHSIEVVIDRIVVKEGVAAR LSDSLETALRLGEGRVMIDVIGEEELMFSEHHACPHCGFSIGELEPRLFSFNSPFGAC PTCDGLGMKLEVDADLVIPNQDLSLKENAVAPWTPISSQYYPQLLEAVCTHYGIDMDV PVKDLPKHQLDKVLYGSGDDLIYFRYENDFGQIREGEIQFEGVLRNIERRYKETGSDF IREQMEQYMSQKSCPTCKGYRLKKEALAVLIDGRHIGKITELSVADALAFFKDLTLSE KDMQIANLILREIVERLSFLDKVGLDYLTLSRAAGTLSGGEAQRIRLATQIGSRLSGV LYILDEPSIGLHQRDNDRLISALKNMRDLGNTLIVVEHDEDTMMAADYLIDIGPGAGI HGGQVISAGTPEEVMEDPNSLTGSYLSGKKFIPLPPERRKPDGRYIEIKGASENNLKK VNAKFPLGTFTAVTGVSGSGKSTLVNEILHKALAQKLHKAKAKPGSHKEIKGLDHLDK VIDIDQAPIGRTPRSNPATYTGVFDDIRDVFAQTNEAKVRGYKKGRFSFNVKGGRCEA CRGDGIIKIEMHFLPDVYVPCEVCHGKRYNRETLEVTYKGKSISDVLDMTVEDALSFF ENIPKIKRKLQTLYDVGLGYITLGQPATTLSGGEAQRVKLASELHKRSTGRTLYILDE PTTGLHVDDIARLLVVLQRLVDNGDTVLVIEHNLDIIKTADYIVDLGPEGGAGGGTIV ASGTPEEITEVEESYTGRYLKPVIERDKTRMKSLLKAKETATS*" /label="uvrA CDS" gene complement(3124973..3127846) /gene="uvrA" /locus_tag="BSU_35160" /old_locus_tag="BSU35160" /label="uvrA gene" downshifts complement(3124990) /Source="Nicolas_upshifts" /id="D1819" /incds=0 /nref=240 /ntot=268 /MaxReadThrough="4.46283" /MaxDrop="5.3695" /score="12.0157254" /energy="-18.6" /TU="U2754,U2756" /idTUdmin="U2755" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3127854..3129839) /gene="uvrB" /locus_tag="BSU_35170" /old_locus_tag="BSU35170" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751826, 16267290, 16426634, 25713353, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751826, 16267290, 16426634, 25713353, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit B)" /protein_id="NP_391397.1" /db_xref="EnsemblGenomes-Gn:BSU35170" /db_xref="EnsemblGenomes-Tr:CAB15534" /db_xref="GOA:P37954" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR004807" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR024759" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036876" /db_xref="PDB:2D7D" /db_xref="PDB:2NMV" /db_xref="PDB:3V4R" /db_xref="SubtiList:BG10502" /db_xref="UniProtKB/Swiss-Prot:P37954" /translation="MKDRFELVSKYQPQGDQPKAIEKLVKGIQEGKKHQTLLGATGTG KTFTVSNLIKEVNKPTLVIAHNKTLAGQLYSEFKEFFPNNAVEYFVSYYDYYQPEAYV PQTDTFIEKDASINDEIDKLRHSATSALFERRDVIIIASVSCIYGLGSPEEYREMVVS LRTEMEIERNELLRKLVDIQYARNDIDFQRGTFRVRGDVVEIFPASRDEHCVRVEFFG DEIERIREVDALTGEILGDRDHVAIFPASHFVTRAEKMEKAIQNIEKELEEQLKVMHE NGKLLEAQRLEQRTRYDLEMMREMGFCSGIENYSRHLTLRPPGSTPYTLLDYFPDDFM IVVDESHVTIPQVRGMFNGDQARKQVLVDHGFRLPSALDNRPLRFEEFEKHMHNIVYV SATPGPYEIEHTDEMVEQIIRPTGLLDPLIDVRPIEGQIDDLIGEIQARIERNERVLV TTLTKKMSEDLTDYLKEIGIKVNYLHSEIKTLERIEIIRDLRLGKYDVLVGINLLREG LDIPEVSLVAILDADKEGFLRSERSLIQTIGRAARNAEGRVIMYADKITKSMEIAINE TKRRREQQERFNEEHGITPKTINKEIRDVIRATVAAEDKAEYKTKAAPKLSKMTKKER QKVVEQMEHEMKEAAKALDFERAAELRDLLLELKAEG*" /label="uvrB CDS" gene complement(3127854..3129839) /gene="uvrB" /locus_tag="BSU_35170" /old_locus_tag="BSU35170" /label="uvrB gene" promotor_-10 complement(3129873..3129892) /Source="Nicolas_upshift_promotors" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3129885) /Source="Nicolas_upshifts" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3129887..3129972) /Source="Nicolas_S_feature" /locus_tag="new_3614978_3615063_c" /HighExp="Gly, Sw, B60, BT, LoTm, Salt, Etha, M9-stat, B36, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1342" promotor_-35 complement(3129904..3129911) /Source="Nicolas_upshift_promotors" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3130017) /Source="Nicolas_upshifts" /id="D1820" /incds=0 /nref=4 /ntot=60 /MaxReadThrough="5.68784" /MaxDrop="3.17938" /score="11.285993" /energy="-12" /TU="U2755,U2756" /idTUdmin="U2755" /TUdmin="-5027" /isTUend="FALSE" /label="downshifts" CDS complement(3130025..3130255) /gene="csbA" /locus_tag="BSU_35180" /old_locus_tag="BSU35180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 1592822, 1744042; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_391398.1" /db_xref="EnsemblGenomes-Gn:BSU35180" /db_xref="EnsemblGenomes-Tr:CAB15535" /db_xref="GOA:P37953" /db_xref="InterPro:IPR019242" /db_xref="SubtiList:BG10501" /db_xref="UniProtKB/Swiss-Prot:P37953" /translation="MITKAVFALFFPFMLVVLFTRVTFNHYVAIALTAALLFASYLKG YTETYFIVGLDVVSLVAGGLYMAKKAAEKKEE*" /label="csbA CDS" gene complement(3130025..3130255) /gene="csbA" /locus_tag="BSU_35180" /old_locus_tag="BSU35180" /label="csbA gene" promotor_-10 complement(3130282..3130301) /Source="Nicolas_upshift_promotors" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="promotor_-10" upshifts complement(3130292) /Source="Nicolas_upshifts" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="upshifts" S_feature complement(3130294..3130358) /Source="Nicolas_S_feature" /locus_tag="new_3615385_3615449_c" /HighExp="Gly, M9-stat, B60, Sw, Etha, LoTm, BT, B36, T1.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1343" promotor_-35 complement(3130315..3130322) /Source="Nicolas_upshift_promotors" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="promotor_-35" promotor_-10 complement(3130335..3130353) /Source="Nicolas_upshift_promotors" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3130356) /Source="Nicolas_upshifts" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3130368..3130374) /Source="Nicolas_upshift_promotors" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3130424) /Source="Nicolas_upshifts" /id="D1821" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.9693" /MaxDrop="4.37808" /score="-1.92287727" /energy="-4.2" /TU="NA" /idTUdmin="U2761" /TUdmin=4752 /isTUend="FALSE" /label="downshifts" promotor_no_box complement(3130450..3130550) /Source="Nicolas_upshift_promotors" /id="U2757" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.378621378621379" /xcortree=1470 /SigmaFactorBS="aatagttaagttggttatattatcctgaaaaatgcggccgta ctggtactgtatgcctattttcttttattctcggaatctggcggcggacttgatgatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3130490) /Source="Nicolas_upshifts" /id="U2757" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.378621378621379" /xcortree=1470 /SigmaFactorBS="aatagttaagttggttatattatcctgaaaaatgcggccgta ctggtactgtatgcctattttcttttattctcggaatctggcggcggacttgatgatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3130572..3130579 /Source="Nicolas_upshift_promotors" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3130593..3130612 /Source="Nicolas_upshift_promotors" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3130610 /Source="Nicolas_upshifts" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 3130702..3133197 /gene="yvkC" /locus_tag="BSU_35190" /old_locus_tag="BSU35190" /EC_number="2.7.-.-" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25012659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase" /protein_id="NP_391399.1" /db_xref="EnsemblGenomes-Gn:BSU35190" /db_xref="EnsemblGenomes-Tr:CAB15536" /db_xref="GOA:O34796" /db_xref="InterPro:IPR002192" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR013815" /db_xref="SubtiList:BG14114" /db_xref="UniProtKB/Swiss-Prot:O34796" /translation="MYSVLFRQAEESSQLAGAKGMNLIKLTKHGLPVPDGFIIQTNAL ARFMEDNQLQETSENVEGGIISGTFSDELKDELTSSFYKLRESYRSVAVRSSSASEDL EGASFAGQYETYLNIKTEEEFLAKVKECWASFFSGRVSSYKKKMNNQIAEPLMGIVVQ GLIDSEMSGVIFSRNPVTHDDRELLISASYGLGEAVVSGNVTPDTFIVNKSSFEIQKE IGAKEIYMESAAEGIAEKETSEDMRSRFCLTDEQVIELAEITKKTEDLYGYPVDIEFG IADHQIYLLQARPITTIDQDKKAAEEKRSFMITDTDMNDFWLNMESNIEGPVSPLFSS FIVPALEYGLKKSMQKFPIGVVVDEVKLYRGHIYSKNQGGQQPPSEDCGKELFPILSE HMYDIINHTYLPFYRTLDQLAQTEHTAESALEAFQKLKAFYLTAYEEHFNIVFPQILL TNKLQAMYQDIQGESENAHFYEMLTGKMNKSLETDRCLWLFSVEVQENPNLLAIFENN KPEQLQEKLEQTDEGRHFLKNVHEFLQEYGWRSVKSHDLIEQIWVENPYFALANIQNY VRNGYHFDNEFQKTKEKREKLYNEFLESIEDPGLRTEFDRYYQWTLNSANIKDDHHFY IDAMLDAKARIFLLKIGELLAENGVIQDREDLWFLYDDEVEQALLHPVSLQEKAEKRR QIFHEYELAQAPAYLGTPTKEQLKAAEEIVGAVIEDEKNTENHIFGIAASSGIATGPV KIIRDANEFSQFAPGDVLVCKMTTPLWTSLFQDAKAIITDTGGILSHAAIIAREYGIP AVLGTRTATERLRDGDIITVDGSSGKITVVSRS*" /label="yvkC CDS" gene 3130702..3133197 /gene="yvkC" /locus_tag="BSU_35190" /old_locus_tag="BSU35190" /label="yvkC gene" misc_feature 3133212..3133216 /Source="Nicolas_upshift_promotors" /id="U2759" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.358641358641359" /psig="0.448551448551449" /xcortree=2520 /SigmaFactorBS="caaaatcacagttgtcagccggtcctgatgcgtccccctctt TCTTAtacaagcggggcgggtgtatacttgtcctgccagtatattcgtgaggtgaaac g" /listShort="yvkB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3133230 /Source="Nicolas_upshifts" /id="U2759" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.358641358641359" /psig="0.448551448551449" /xcortree=2520 /SigmaFactorBS="caaaatcacagttgtcagccggtcctgatgcgtccccctctt TCTTAtacaagcggggcgggtgtatacttgtcctgccagtatattcgtgaggtgaaac g" /listShort="yvkB" /GFF_Attribute="listLong" /label="upshifts" CDS 3133273..3133842 /gene="yvkB" /locus_tag="BSU_35200" /old_locus_tag="BSU35200" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_391400.1" /db_xref="EnsemblGenomes-Gn:BSU35200" /db_xref="EnsemblGenomes-Tr:CAB15537" /db_xref="GOA:O34643" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG14113" /db_xref="UniProtKB/Swiss-Prot:O34643" /translation="MRPTNKRILDAAMQLLVKKGYRATTTKEIAEKANVSEATIFRNF KNKQGLVEALLSQHSSNRGSILEQTEGDLYKDLLHIGTCLLEELEHRKDIIKISFREP AMFQDVINHVTEYPQSMKQLLVDYLKTMGEKGVIQTGNEAEHADVFMSIIFGYFIHRL HLGDRVISMPQEKMLEHSTALFVKGISAD*" /label="yvkB CDS" gene 3133273..3133842 /gene="yvkB" /locus_tag="BSU_35200" /old_locus_tag="BSU35200" /label="yvkB gene" CDS 3133873..3135207 /gene="yvkA" /locus_tag="BSU_35210" /old_locus_tag="BSU35210" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391401.1" /db_xref="EnsemblGenomes-Gn:BSU35210" /db_xref="EnsemblGenomes-Tr:CAB15538" /db_xref="GOA:O34502" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14112" /db_xref="UniProtKB/Swiss-Prot:O34502" /translation="MSSRKEWALIVSLLLGAILVPINSTMIAVALSSISHTYNESIAS ITWVVTVYLIVMAVTQPIAGKLGDMYGNKTMYLWGVGLFLIASLGCALSPSLLLLIVF RALQAVGGALLTPNSIAIIRHVVSEKRLPKVFGFFGLGAGLGAALGPFIGSILIDSFS WHSIFWVNIPFLAIALFTALTMFPQYKENKSDAPLDIIGSLLLAGSIVSIILLTKNEA PWGYTVYSVLILLFVPLFFRREKRTQHPIIDFALFKSSTFTNANLSVLLSNLMMYAVL LIMPLFMTNQFGLNTSNSGMALSVFSIFMSASNWVGAQLHHKWGAKKIIFLSFAMMAG ANLLFLLLSSSHSVLFLMLSLILGGLASGVGLTSMQVSSLATVDPGMSGVASGIFSTF RYFGSIISSALIGLISGYHTLFMILFAVSIIGVFVSLGIKSDETARIEKNSA*" /label="yvkA CDS" gene 3133873..3135207 /gene="yvkA" /locus_tag="BSU_35210" /old_locus_tag="BSU35210" /label="yvkA gene" downshifts 3135188 /Source="Nicolas_upshifts" /id="D1822" /incds=0 /nref=4 /ntot=118 /MaxReadThrough="0.94661" /MaxDrop="3.57731" /score="21.0606505" /energy="-28.8" /TU="NA" /idTUdmin="U2759" /TUdmin=1276 /isTUend="FALSE" /label="downshifts" CDS complement(3135255..3136448) /gene="minJ" /locus_tag="BSU_35220" /old_locus_tag="BSU35220" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16030230, 16850406, 18976281, 19019154, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16030230, 16850406, 18976281, 19019154, 26735940; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="topological determinant of cell division" /protein_id="NP_391402.1" /db_xref="EnsemblGenomes-Gn:BSU35220" /db_xref="EnsemblGenomes-Tr:CAB15539" /db_xref="GOA:O34375" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG14111" /db_xref="UniProtKB/Swiss-Prot:O34375" /translation="MSVQWGIELLKSAGLFFLHPLFWFFIIITLAFGYVRIKRERKTF HTRIADIYDDLKFTYTKGLIPGLLLSVILGGLGISIPLGLLAIIAVITAAAAFTLRAN WMSAAYIVSVSMLIGFGLQIYQAEPFLERFPQGFAVVWPAVAVFLGLLIITEGAVAYR SAHVRTSPALVVSSRGLPIGQQLANRVWLLPLFLLVPGNGLESHLSWWPVFTVPGGSF HFLWIPYFVGFGQRVQGSLPETSIRITAKRVCILGLAVAVLGAASLLWTPLAGAAVCT ALLGRIFLSIKQRVNDNAAPFYFSKRDQGLMVLGIIPNTPAEDLELKIGEIITKVNGI PVKNVSDFYEALQHNRAYVKLEIIGLNGEIRFDQRASYEGEHHELGILFVKDDREDEA VASGS*" /label="minJ CDS" gene complement(3135255..3136448) /gene="minJ" /locus_tag="BSU_35220" /old_locus_tag="BSU35220" /label="minJ gene" downshifts complement(3135264) /Source="Nicolas_upshifts" /id="D1823" /incds=0 /nref=3 /ntot=85 /MaxReadThrough="3.18641" /MaxDrop="3.13207" /score="21.4231982" /energy="-25.6" /TU="U2761" /idTUdmin="U2760" /TUdmin=66 /isTUend="FALSE" /label="downshifts" downshifts complement(3135329) /Source="Nicolas_upshifts" /id="D1824" /incds=1 /nref=94 /ntot=239 /MaxReadThrough="4.11808" /MaxDrop="4.31508" /score="21.4231982" /energy="-25.6" /TU="U2761" /idTUdmin="U2760" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(3136449..3136526) /Source="Nicolas_S_feature" /locus_tag="new_3621540_3621617_c" /HighExp="LBGstat, Lbstat, M0t90, Cold, M/G, GM 10, GM 25, GM 15, GM 60, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigGF" /TUshortPSig="0.945, 0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1344" downshifts complement(3136452) /Source="Nicolas_upshifts" /id="D1825" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="6.36185" /MaxDrop="3.35962" /score="-9.46264764" /energy="-7.1" /TU="U2760,U2761,U2762" /idTUdmin="U2762" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(3136527..3136865) /gene="swrAAc" /locus_tag="BSU_35230" /old_locus_tag="BSU35230" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15066026, 16030230" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16030230; Product type cp: cell process" /pseudo /codon_start=1 /transl_table=11 /product="swarming motility protein fragment; C-terminal part of swrAA" /db_xref="GOA:O32266" /db_xref="InterPro:IPR035388" /db_xref="PSEUDO:CAB15540.1" /db_xref="SubtiList:BG14160" /db_xref="UniProtKB/Swiss-Prot:O32266" /translation="MCVKKKYYELVEQLKDRTQDVTFSATKALSLLMLFSRYLVNYTN VESVNDINEECAKHYFNYLMKNHKRLGINLTDIKRSMHLISGLLDVDVNHYLKDFSLS NVTLWMTQER*" /label="swrAAc CDS" gene complement(3136527..3136865) /gene="swrAAc" /locus_tag="BSU_35230" /old_locus_tag="BSU35230" /pseudo /label="swrAAc gene" CDS complement(3136840..3136956) /gene="swrAAn" /locus_tag="BSU_35239" /old_locus_tag="BSU35239" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type cp: cell process" /pseudo /codon_start=1 /transl_table=11 /product="swarming motility protein; N-terminal part of swrAA" /db_xref="PSEUDO:CAX52697.1" /translation="MLVSTPVLLLILARAYLYKENGGSQLKRASIVREKKIL*" /label="swrAAn CDS" gene complement(3136840..3136956) /gene="swrAAn" /locus_tag="BSU_35239" /old_locus_tag="BSU35239" /pseudo /label="swrAAn gene" S_feature complement(3136957..3137046) /Source="Nicolas_S_feature" /locus_tag="new_3622048_3622137_c" /HighExp="LBGstat, M0t90, Cold, Lbstat, GM 25, Gly, nit, GM 15, GM 10, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigGF" /TUshortPSig="0.945, 0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1345" promotor_-10 complement(3137028..3137046) /Source="Nicolas_upshift_promotors" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3137046) /Source="Nicolas_upshifts" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3137048..3137128) /Source="Nicolas_S_feature" /locus_tag="new_3622139_3622219_c" /HighExp="LBGstat, Lbstat, Cold, M0t90, GM 25, nit, Gly, M/G, MG 150, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigGF" /TUshortPSig="0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1346" promotor_-35 complement(3137060..3137065) /Source="Nicolas_upshift_promotors" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3137114..3137132) /Source="Nicolas_upshift_promotors" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3137128) /Source="Nicolas_upshifts" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3137146..3137153) /Source="Nicolas_upshift_promotors" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3137265..3138707) /gene="ctpB" /locus_tag="BSU_35240" /old_locus_tag="BSU35240" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14526016, 17557826, 27342562" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14526016, 17557826, 27342562; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="PDZ-containing carboxyl-terminal protease processing protease [Zn(II)]" /protein_id="NP_391404.1" /db_xref="EnsemblGenomes-Gn:BSU35240" /db_xref="EnsemblGenomes-Tr:CAB15541" /db_xref="GOA:O35002" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR004447" /db_xref="InterPro:IPR005151" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036034" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="PDB:4C2C" /db_xref="PDB:4C2D" /db_xref="PDB:4C2E" /db_xref="PDB:4C2F" /db_xref="PDB:4C2G" /db_xref="PDB:4C2H" /db_xref="SubtiList:BG14110" /db_xref="UniProtKB/Swiss-Prot:O35002" /translation="MNQKIMAVIAAGSMLFGGAGVYAGINLLEMDKPQTAAVPATAQA DSERDKAMDKIEKAYELISNEYVEKVDREKLLEGAIQGMLSTLNDPYSVYMDKQTAKQ FSDSLDSSFEGIGAEVGMEDGKIIIVSPFKKSPAEKAGLKPNDEIISINGESMAGKDL NHAVLKIRGKKGSSVSMKIQRPGTKKQLSFRIKRAEIPLETVFASEKKVQGHSVGYIA ISTFSEHTAEDFAKALRELEKKEIEGLVIDVRGNPGGYLQSVEEILKHFVTKDQPYIQ IAERNGDKKRYFSTLTHKKAYPVNVITDKGSASASEILAGALKEAGHYDVVGDTSFGK GTVQQAVPMGDGSNIKLTLYKWLTPNGNWIHKKGIEPTIAIKQPDYFSAGPLQLKEPL KVDMNNEDVKHAQVLLKGLSFDPGREDGYFSKDMKKAVMAFQDQNKLNKTGVIDTRTA ETLNQQIEKKKSDEKNDLQLQTALKSLFVN*" /label="ctpB CDS" gene complement(3137265..3138707) /gene="ctpB" /locus_tag="BSU_35240" /old_locus_tag="BSU35240" /label="ctpB gene" downshifts complement(3137354) /Source="Nicolas_upshifts" /id="D1826" /incds=1 /nref=1 /ntot=30 /MaxReadThrough="3.56833" /MaxDrop="3.1636" /score="0.562448109" /energy="-11.6" /TU="U2762" /idTUdmin="U2762" /TUdmin="-1122" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3138753..3138764) /Source="Nicolas_upshift_promotors" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3138764) /Source="Nicolas_upshifts" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3138779..3138785) /Source="Nicolas_upshift_promotors" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3138847..3139737) /gene="ftsX" /locus_tag="BSU_35250" /old_locus_tag="BSU35250" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16352817, 17071757, 17307852, 18573177, 23855774, 23869552" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352817, 17071757, 17307852, 18573177, 23855774, 23869552; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell-division ABC transporter" /protein_id="NP_391405.1" /db_xref="EnsemblGenomes-Gn:BSU35250" /db_xref="EnsemblGenomes-Tr:CAB15542" /db_xref="GOA:O34876" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR004513" /db_xref="SubtiList:BG12591" /db_xref="UniProtKB/Swiss-Prot:O34876" /translation="MIKILGRHLRESFKSLGRNTWMTFASISAVTVTLILVGVFLVIM LNLNNMATNAEKQVEIKVLIDLTADQKAQDKLQNDIKELKGIQSVTFSSKEKELDQLV DSFGDSGKSLTMKDQENPLNDAFVVKTTDPHDTPNVAKKIEKMDHVYKVTYGKEEVSR LFKVVGVSRNIGIALIIGLVFTAMFLISNTIKITIFARRKEIEIMKLVGATNWFIRWP FFLEGLLLGVFGSVIPIALVLSTYQYVIGWVVPKVQGSFVSLLPYNPFVFQVSLVLIA IGAVIGVWGSLTSIRKFLRV*" /label="ftsX CDS" gene complement(3138847..3139737) /gene="ftsX" /locus_tag="BSU_35250" /old_locus_tag="BSU35250" /label="ftsX gene" downshifts complement(3138864) /Source="Nicolas_upshifts" /id="D1827" /incds=0 /nref=144 /ntot=253 /MaxReadThrough="3.3693" /MaxDrop="6.15417" /score="15.3496791" /energy="-14.6" /TU="U2763" /idTUdmin="U2763" /TUdmin="-102" /isTUend="FALSE" /label="downshifts" CDS complement(3139730..3140416) /gene="ftsE" /locus_tag="BSU_35260" /old_locus_tag="BSU35260" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16352817, 17071757, 17307852, 18573177, 22006326, 23855774, 27167971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352817, 17071757, 17307852, 18573177, 22006326, 23855774, 27167971; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division signal transducer (ATP-binding protein)" /protein_id="NP_391406.1" /db_xref="EnsemblGenomes-Gn:BSU35260" /db_xref="EnsemblGenomes-Tr:CAB15543" /db_xref="GOA:O34814" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005286" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12590" /db_xref="UniProtKB/Swiss-Prot:O34814" /translation="MIEMKEVYKAYPNGVKALNGISVTIHPGEFVYVVGPSGAGKSTF IKMIYREEKPTKGQILINHKDLATIKEKEIPFVRRKIGVVFQDFKLLPKLTVFENVAF ALEVIGEQPSVIKKRVLEVLDLVQLKHKARQFPDQLSGGEQQRVSIARSIVNNPDVVI ADEPTGNLDPDTSWEVMKTLEEINNRGTTVVMATHNKEIVNTMKKRVIAIEDGIIVRD ESRGEYGSYD*" /label="ftsE CDS" gene complement(3139730..3140416) /gene="ftsE" /locus_tag="BSU_35260" /old_locus_tag="BSU35260" /label="ftsE gene" S_feature complement(3140417..3140549) /Source="Nicolas_S_feature" /locus_tag="new_3625508_3625640_c" /HighExp="Cold, UNK1, MG-0.2, MG 15, MG-0.1, C30, MG 25, MG 10, M9-exp, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.998" /label="S1347" promotor_-10 complement(3140539..3140558) /Source="Nicolas_upshift_promotors" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3140549) /Source="Nicolas_upshifts" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3140573..3140576) /Source="Nicolas_upshift_promotors" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3140650..3140988) /gene="cccB" /locus_tag="BSU_35270" /old_locus_tag="BSU35270" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10473570, 19222757" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10473570, 19222757; Product type f: factor" /codon_start=1 /transl_table=11 /product="cytochrome c551" /protein_id="NP_391407.1" /db_xref="EnsemblGenomes-Gn:BSU35270" /db_xref="EnsemblGenomes-Tr:CAB15544" /db_xref="GOA:O34594" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012218" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG12574" /db_xref="UniProtKB/Swiss-Prot:O34594" /translation="MKSKLSILMIGFALSVLLAACGSNDAKEEKTDTGSKTEATASEG EELYQQSCVGCHGKDLEGVSGPNLQEVGGKYDEHKIESIIKNGRGNMPKGLVDDNEAA VIAKWLSEKK*" /label="cccB CDS" gene complement(3140650..3140988) /gene="cccB" /locus_tag="BSU_35270" /old_locus_tag="BSU35270" /label="cccB gene" downshifts complement(3140651) /Source="Nicolas_upshifts" /id="D1828" /incds=0 /nref=192 /ntot=265 /MaxReadThrough="3.58546" /MaxDrop="6.88513" /score="18.0901387" /energy="-16.8" /TU="U2764" /idTUdmin="U2765" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3141015..3141034) /Source="Nicolas_upshift_promotors" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-10" upshifts complement(3141028) /Source="Nicolas_upshifts" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="upshifts" CDS complement(3141037..3141921) /gene="yvjA" /locus_tag="BSU_35280" /old_locus_tag="BSU35280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10473570, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391408.2" /db_xref="EnsemblGenomes-Gn:BSU35280" /db_xref="EnsemblGenomes-Tr:CAB15545" /db_xref="GOA:O34792" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG14109" /db_xref="UniProtKB/Swiss-Prot:O34792" /translation="MLSESIGRNGGYMMDVRNKTLWILRDYVYILIGAAITAVSFNVF LLPNKIAAGGVSGISTILQSYGFEAAYVQWIINIPLFIAGVILLGGKFGLKTLAGSVF LPLVVFLTRDIQPATHHELLAAIFGGVGIGIGIGIVYLGKGSTGGTALAAQIIHKYSG LSLGKCLAIIDGMIVVTAMIVFNIEQGLYAMLGVYVSSKTIDVVQVGFNRSKMALIIT KQEQAVKEAVLQKIDRGVTKISAVGGYTDDDRPILMCVVGQTEFTKLKQIVKQIDESA FVIVADASEVLGEGFKRA*" /label="yvjA CDS" gene complement(3141037..3141921) /gene="yvjA" /locus_tag="BSU_35280" /old_locus_tag="BSU35280" /label="yvjA gene" promotor_-35 complement(3141048..3141055) /Source="Nicolas_upshift_promotors" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-35" promotor_-10 complement(3141909..3141928) /Source="Nicolas_upshift_promotors" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-10" upshifts complement(3141930) /Source="Nicolas_upshifts" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="upshifts" promotor_-35 complement(3141943..3141950) /Source="Nicolas_upshift_promotors" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-35" CDS join(complement(3143078..3143149), complement(3142048..3143076)) /gene="prfB" /locus_tag="BSU_35290" /old_locus_tag="BSU35290" /experiment="publication(s) with functional evidences, PMID:1408743, 9696765, 9882663" /ribosomal_slippage /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1408743, 9696765, 9882663; Product type f: factor" /codon_start=1 /transl_table=11 /product="peptide chain release factor 2" /protein_id="NP_391409.1" /db_xref="EnsemblGenomes-Gn:BSU35290" /db_xref="EnsemblGenomes-Tr:CAB15546" /db_xref="GOA:P28367" /db_xref="InterPro:IPR000352" /db_xref="InterPro:IPR004374" /db_xref="InterPro:IPR005139" /db_xref="InterPro:IPR020853" /db_xref="SubtiList:BG10742" /db_xref="UniProtKB/Swiss-Prot:P28367" /translation="MELSEIRAELENMASRLADFRGSLDLESKEARIAELDEQMADPE FWNDQQKAQTVINEANGLKDYVNSYKKLNESHEELQMTHDLLKEEPDTDLQLELEKEL KSLTKEFNEFELQLLLSEPYDKNNAILELHPGAGGTESQDWGSMLLRMYTRWGERRGF KVETLDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHRLVRISPFDSSGRRHTSFVS CEVMPEFNDEIDIDIRTEDIKVDTYRASGAGGQHVNTTDSAVRITHLPTNVVVTCQTE RSQIKNRERAMKMLKAKLYQRRIEEQQAELDEIRGEQKEIGWGSQIRSYVFHPYSMVK DHRTNTEMGNVQAVMDGDIDTFIDAYLRSKLS*" /label="prfB CDS" gene complement(3142048..3143149) /gene="prfB" /locus_tag="BSU_35290" /old_locus_tag="BSU35290" /label="prfB gene" downshifts complement(3142064) /Source="Nicolas_upshifts" /id="D1829" /incds=0 /nref=193 /ntot=257 /MaxReadThrough="2.78016" /MaxDrop="6.41678" /score="27.1588259" /energy="-9.8" /TU="NA" /idTUdmin="U2766" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(3143150..3143218) /Source="Nicolas_S_feature" /locus_tag="new_3628241_3628309_c" /HighExp="Etha, Sw, Cold, BC, G150, BI, dia15, Mt0, LBGtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigD" /TUshortPSig="0.994, 0.997, 1, 1" /TUlongSig="SigA, SigD" /TUlongPSig="0.999, 1" /label="S1348" CDS complement(3143219..3145744) /gene="secA" /locus_tag="BSU_35300" /old_locus_tag="BSU35300" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9880811, 10074074, 10481054, 10559168, 10713435, 11021932, 12682299, 14621992, 16243836, 18923516, 23167435, 24592260, 26607006, 27336478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9880811, 10074074, 10481054, 10559168, 10713435, 11021932, 12682299, 14621992, 16243836, 18923516, 23167435, 24592260, 26607006, 27336478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="translocase binding subunit (ATPase)" /protein_id="NP_391410.1" /db_xref="EnsemblGenomes-Gn:BSU35300" /db_xref="EnsemblGenomes-Tr:CAB15547" /db_xref="GOA:P28366" /db_xref="InterPro:IPR000185" /db_xref="InterPro:IPR004027" /db_xref="InterPro:IPR011115" /db_xref="InterPro:IPR011116" /db_xref="InterPro:IPR011130" /db_xref="InterPro:IPR014018" /db_xref="InterPro:IPR020937" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036266" /db_xref="InterPro:IPR036670" /db_xref="PDB:1M6N" /db_xref="PDB:1M74" /db_xref="PDB:1TF2" /db_xref="PDB:1TF5" /db_xref="PDB:2IBM" /db_xref="PDB:3DL8" /db_xref="PDB:3IQM" /db_xref="PDB:3IQY" /db_xref="PDB:3JV2" /db_xref="PDB:5EUL" /db_xref="SubtiList:BG10741" /db_xref="UniProtKB/Swiss-Prot:P28366" /translation="MLGILNKMFDPTKRTLNRYEKIANDIDAIRGDYENLSDDALKHK TIEFKERLEKGATTDDLLVEAFAVVREASRRVTGMFPFKVQLMGGVALHDGNIAEMKT GEGKTLTSTLPVYLNALTGKGVHVVTVNEYLASRDAEQMGKIFEFLGLTVGLNLNSMS KDEKREAYAADITYSTNNELGFDYLRDNMVLYKEQMVQRPLHFAVIDEVDSILIDEAR TPLIISGQAAKSTKLYVQANAFVRTLKAEKDYTYDIKTKAVQLTEEGMTKAEKAFGID NLFDVKHVALNHHINQALKAHVAMQKDVDYVVEDGQVVIVDSFTGRLMKGRRYSEGLH QAIEAKEGLEIQNESMTLATITFQNYFRMYEKLAGMTGTAKTEEEEFRNIYNMQVVTI PTNRPVVRDDRPDLIYRTMEGKFKAVAEDVAQRYMTGQPVLVGTVAVETSELISKLLK NKGIPHQVLNAKNHEREAQIIEEAGQKGAVTIATNMAGRGTDIKLGEGVKELGGLAVV GTERHESRRIDNQLRGRSGRQGDPGITQFYLSMEDELMRRFGAERTMAMLDRFGMDDS TPIQSKMVSRAVESSQKRVEGNNFDSRKQLLQYDDVLRQQREVIYKQRFEVIDSENLR EIVENMIKSSLERAIAAYTPREELPEEWKLDGLVDLINTTYLDEGALEKSDIFGKEPD EMLELIMDRIITKYNEKEEQFGKEQMREFEKVIVLRAVDSKWMDHIDAMDQLRQGIHL RAYAQTNPLREYQMEGFAMFEHMIESIEDEVAKFVMKAEIENNLEREEVVQGQTTAHQ PQEGDDNKKAKKAPVRKVVDIGRNAPCHCGSGKKYKNCCGRTE*" /label="secA CDS" gene complement(3143219..3145744) /gene="secA" /locus_tag="BSU_35300" /old_locus_tag="BSU35300" /label="secA gene" S_feature complement(3145745..3145825) /Source="Nicolas_S_feature" /locus_tag="new_3630836_3630916_c" /HighExp="Etha, M9-stat, T0.30H, B60, dia5, Cold, dia15, Lbexp, Salt, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigD" /TUshortPSig="0.994, 0.997, 1, 1" /TUlongSig="SigA, SigD" /TUlongPSig="0.999, 1" /label="S1349" misc_feature complement(3145815..3145834) /Source="Nicolas_upshift_promotors" /id="U2766" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.69030969030969" /psig="0.994005994005994" /xcortree=106 /SigmaFactorBS="cggaaggtttttgtttttcttatttgcaaattctttggaaat aacaaaaggTATGATATGATAATGAGAGGtatacatggactagtaaattatttataca t" /listShort="S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3145825) /Source="Nicolas_upshifts" /id="U2766" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.69030969030969" /psig="0.994005994005994" /xcortree=106 /SigmaFactorBS="cggaaggtttttgtttttcttatttgcaaattctttggaaat aacaaaaggTATGATATGATAATGAGAGGtatacatggactagtaaattatttataca t" /listShort="S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3145912..3146481) /gene="hpf" /locus_tag="BSU_35310" /old_locus_tag="BSU35310" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11948165, 16324148, 17274076, 17277072, 19747895, 22720735, 22950019, 28468753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11948165, 16324148, 17274076, 17277072, 19747895, 22720735, 22950019, 28468753; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome-associated sigma 54 modulation protein;ribosome dimerisation factor" /protein_id="NP_391411.1" /db_xref="EnsemblGenomes-Gn:BSU35310" /db_xref="EnsemblGenomes-Tr:CAB15548" /db_xref="GOA:P28368" /db_xref="InterPro:IPR003489" /db_xref="InterPro:IPR032528" /db_xref="InterPro:IPR034694" /db_xref="InterPro:IPR036567" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10740" /db_xref="UniProtKB/Swiss-Prot:P28368" /translation="MNYNIRGENIEVTPALKDHVERKIGKLERYFDHSVDADVNVNLK FYNDKESKVEVTIPMTDLALRSEVHNEDMYNAIDLATNKLERQIRKHKTKVNRKFREQ GSPKYLLANGLGSDTDIAVQDDIEEEESLDIVRQKRFNLKPMDSEEAILQMNMLGHNF FVFTNAETNLTNVVYRRNDGKYGLIEPTE*" /label="hpf CDS" gene complement(3145912..3146481) /gene="hpf" /locus_tag="BSU_35310" /old_locus_tag="BSU35310" /label="hpf gene" downshifts complement(3145920) /Source="Nicolas_upshifts" /id="D1830" /incds=0 /nref=78 /ntot=209 /MaxReadThrough="8.66806" /MaxDrop="4.7023" /score="29.9030506" /energy="-12.2" /TU="U2768,U2769,U2770,U2773" /idTUdmin="U2773" /TUdmin="-74" /isTUend="FALSE" /label="downshifts" promotor_-35 3146448..3146454 /Source="Nicolas_upshift_promotors" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3146467..3146486 /Source="Nicolas_upshift_promotors" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3146474 /Source="Nicolas_upshifts" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3146508..3146526) /Source="Nicolas_upshift_promotors" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3146516) /Source="Nicolas_upshifts" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3146518..3146638) /Source="Nicolas_S_feature" /locus_tag="new_3631609_3631729_c" /HighExp="C30, M0t90, S4, Lbstat, S5, M40t90, Glucon, Gly, C90, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigD, SigD" /TUshortPSig="1, 1, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1350" promotor_-35 complement(3146538..3146546) /Source="Nicolas_upshift_promotors" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3146622..3146640) /Source="Nicolas_upshift_promotors" /id="U2769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1221 /SigmaFactorBS="tgtatggaaccctttttaatcaattaggcgtgtgtgaGGTAT TtgtttcgttcaatcaGCATATACATATACCTCCGaaccgccaataacagagcaaata c" /listShort="S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3146638) /Source="Nicolas_upshifts" /id="U2769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1221 /SigmaFactorBS="tgtatggaaccctttttaatcaattaggcgtgtgtgaGGTAT TtgtttcgttcaatcaGCATATACATATACCTCCGaaccgccaataacagagcaaata c" /listShort="S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3146656..3146661) /Source="Nicolas_upshift_promotors" /id="U2769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1221 /SigmaFactorBS="tgtatggaaccctttttaatcaattaggcgtgtgtgaGGTAT TtgtttcgttcaatcaGCATATACATATACCTCCGaaccgccaataacagagcaaata c" /listShort="S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3146672..3147049) /gene="yvzG" /locus_tag="BSU_35319" /old_locus_tag="BSU35319" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097791.1" /db_xref="EnsemblGenomes-Gn:BSU35319" /db_xref="EnsemblGenomes-Tr:CAX52698" /db_xref="UniProtKB/Swiss-Prot:C0H3R9" /translation="MKSIEDYTLLSAYYHLLFTIEEGLCYLIEAEENLSKTEGDRIYQ DLIQAFFYLDSTHSTLLFIMDSRCAEICVKAFDQIFAEFDQLVSFSFPSHEFCEYLKE HFLIHYRKWMLSIHQCMEPFLIN*" /label="yvzG CDS" gene complement(3146672..3147049) /gene="yvzG" /locus_tag="BSU_35319" /old_locus_tag="BSU35319" /label="yvzG gene" CDS complement(3147059..3147400) /gene="fliT" /locus_tag="BSU_35320" /old_locus_tag="BSU35320" /function="16.3: Control" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16952964; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar assembly protein FliT involved in control of flagella expression" /protein_id="NP_391412.1" /db_xref="EnsemblGenomes-Gn:BSU35320" /db_xref="EnsemblGenomes-Tr:CAB15549" /db_xref="GOA:P39740" /db_xref="SubtiList:BG10923" /db_xref="UniProtKB/Swiss-Prot:P39740" /translation="MNNIDQLYTETKSMLSHIQNTPESDELLKQIEDFVATRSELIQE ISLPLSEEERKQMKLILTWDQLIVKEMERLKQSIATELQQMKRKRVMHTTYLNPYNNI TIDGTYYDKRK*" /label="fliT CDS" gene complement(3147059..3147400) /gene="fliT" /locus_tag="BSU_35320" /old_locus_tag="BSU35320" /label="fliT gene" CDS complement(3147397..3147798) /gene="fliS" /locus_tag="BSU_35330" /old_locus_tag="BSU35330" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16806204, 16936039, 20534509, 23144244, 23874669; Product type s : structure" /codon_start=1 /transl_table=11 /product="flagellar assembly protein FliS" /protein_id="NP_391413.1" /db_xref="EnsemblGenomes-Gn:BSU35330" /db_xref="EnsemblGenomes-Tr:CAB15550" /db_xref="GOA:P39739" /db_xref="InterPro:IPR003713" /db_xref="InterPro:IPR036584" /db_xref="PDB:1VH6" /db_xref="SubtiList:BG10922" /db_xref="UniProtKB/Swiss-Prot:P39739" /translation="MAIQNPYTAYQQNSVNTATPGELTLMLYNGCLKFIRLAAQAIEN DDMERKNENLIKAQNIIQELNFTLNRNIELSASMGAMYDYMYRRLVQANIKNDTGMLA EVEGYVTDFRDAWKQAIQSERKDRHGSGGIA*" /label="fliS CDS" gene complement(3147397..3147798) /gene="fliS" /locus_tag="BSU_35330" /old_locus_tag="BSU35330" /label="fliS gene" CDS complement(3147820..3149316) /gene="fliD" /locus_tag="BSU_35340" /old_locus_tag="BSU35340" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9648743, 12354229, 24296669, 25355936; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar hook-associated capping protein 2 (HAP2)" /protein_id="NP_391414.1" /db_xref="EnsemblGenomes-Gn:BSU35340" /db_xref="EnsemblGenomes-Tr:CAB15551" /db_xref="GOA:P39738" /db_xref="InterPro:IPR003481" /db_xref="InterPro:IPR010809" /db_xref="InterPro:IPR010810" /db_xref="SubtiList:BG10921" /db_xref="UniProtKB/Swiss-Prot:P39738" /translation="MVTRITGLASGMDIDDIVSKLMQTERAPLDKLTQKKQTLEWQRD SYREVNSKIKELQDYMSKNTLTYPSTYQSKTVTSSNESVLTATGSVSAPNSSSTVEVA SLATAATYKANNYTGYTQGDYNLAFNVVAPGETTAKTVNISVTSADTIDNVISKLNSS DLGVSAFKDKIWNGTEYVETIAFSSKATGAGGSIQAADSATADFMSGQLGFSLDADNK LTAYKEGTNAKVTINGFEMEKLTNNFTVNGVTYSIKNTTAATGPVTTSVSTDVDGIYN QIKEFVDKYNELVDSLNEKLKEEKYRDYTPLTSEQKEAMSDKEVELWEEKAKSGLLRN DSSISTGTNQMRTDFYTQVNADGKTYQLTEFGITTSSAYQLRGHLEINEEKLKAKIAE DPQGVANLFTSGTNDSNYSDKGIMKRITNTLRSTVKSIEAKAGNSTMGASSYSIGKNL NSISTEITDMQDRLNTIENRYYSKFSAMDSAIQKMNEQASYLSQLLVQ*" /label="fliD CDS" gene complement(3147820..3149316) /gene="fliD" /locus_tag="BSU_35340" /old_locus_tag="BSU35340" /label="fliD gene" CDS complement(3149334..3149663) /gene="yvyC" /locus_tag="BSU_35350" /old_locus_tag="BSU35350" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12354229, 19455708; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative flagellar protein of unknown function" /protein_id="NP_391415.1" /db_xref="EnsemblGenomes-Gn:BSU35350" /db_xref="EnsemblGenomes-Tr:CAB15552" /db_xref="InterPro:IPR005186" /db_xref="InterPro:IPR035924" /db_xref="PDB:2HC5" /db_xref="SubtiList:BG10920" /db_xref="UniProtKB/Swiss-Prot:P39737" /translation="MNIERLTTLQPVWDRYDTQIHNQKDNDNEVPVHQVSYTNLAEMV GEMNKLLEPSQVHLKFELHDKLNEYYVKVIEDSTNEVIREIPPKRWLDFYAAMTEFLG LFVDEKK*" /label="yvyC CDS" gene complement(3149334..3149663) /gene="yvyC" /locus_tag="BSU_35350" /old_locus_tag="BSU35350" /label="yvyC gene" downshifts 3149660 /Source="Nicolas_upshifts" /id="D1831" /incds=0 /nref=33 /ntot=140 /MaxReadThrough="2.74277" /MaxDrop="4.24086" /score="8.30527041" /energy="-10.1" /TU="NA" /idTUdmin="U2774" /TUdmin="-3062" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3149685..3149703) /Source="Nicolas_upshift_promotors" /id="U2770" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2807 /SigmaFactorBS="agaaatctaaaacagaagatttttttccaaaaatatGTGTAA TCttatctcgacttaGTCGATATAAACGATAGATtggggcataggggatgatcaattg a" /listShort="yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3149700) /Source="Nicolas_upshifts" /id="U2770" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2807 /SigmaFactorBS="agaaatctaaaacagaagatttttttccaaaaatatGTGTAA TCttatctcgacttaGTCGATATAAACGATAGATtggggcataggggatgatcaattg a" /listShort="yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3149702..3149806) /Source="Nicolas_S_feature" /locus_tag="new_3634793_3634897_c" /HighExp="Lbstat, Cold, Gly, S0, Glu, Pyr, M/G, M0t90, C30, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1351" promotor_-35 complement(3149717..3149724) /Source="Nicolas_upshift_promotors" /id="U2770" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2807 /SigmaFactorBS="agaaatctaaaacagaagatttttttccaaaaatatGTGTAA TCttatctcgacttaGTCGATATAAACGATAGATtggggcataggggatgatcaattg a" /listShort="yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3149795..3149814) /Source="Nicolas_upshift_promotors" /id="U2771" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2693 /SigmaFactorBS="tcttttaatttaaatttctatctcctaatcattcctcatcct gtcactaactCATGATATAATAACCGGATTctccactaactttttataaatgtatttc c" /listShort="S1351, yvyC, fliD, fliS, fliT, yvzG" /listLong="S1350, yvyD, S1349, secA, S1348, prfB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3149806) /Source="Nicolas_upshifts" /id="U2771" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2693 /SigmaFactorBS="tcttttaatttaaatttctatctcctaatcattcctcatcct gtcactaactCATGATATAATAACCGGATTctccactaactttttataaatgtatttc c" /listShort="S1351, yvyC, fliD, fliS, fliT, yvzG" /listLong="S1350, yvyD, S1349, secA, S1348, prfB" /label="upshifts" CDS complement(3149896..3150810) /gene="hag" /locus_tag="BSU_35360" /old_locus_tag="BSU35360" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8045886, 9648743, 12730172, 14762011, 15342569, 22720735, 25355936, 28800172, 29124898" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045886, 9648743, 12730172, 14762011, 15342569, 22720735, 25355936, 28800172, 29124898; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellin protein" /protein_id="NP_391416.1" /db_xref="EnsemblGenomes-Gn:BSU35360" /db_xref="EnsemblGenomes-Tr:CAB15553" /db_xref="GOA:P02968" /db_xref="InterPro:IPR001029" /db_xref="InterPro:IPR001492" /db_xref="SubtiList:BG10655" /db_xref="UniProtKB/Swiss-Prot:P02968" /translation="MRINHNIAALNTLNRLSSNNSASQKNMEKLSSGLRINRAGDDAA GLAISEKMRGQIRGLEMASKNSQDGISLIQTAEGALTETHAILQRVRELVVQAGNTGT QDKATDLQSIQDEISALTDEIDGISNRTEFNGKKLLDGTYKVDTATPANQKNLVFQIG ANATQQISVNIEDMGADALGIKEADGSIAALHSVNDLDVTKFADNAADTADIGFDAQL KVVDEAINQVSSQRAKLGAVQNRLEHTINNLSASGENLTAAESRIRDVDMAKEMSEFT KNNILSQASQAMLAQANQQPQNVLQLLR*" /label="hag CDS" gene complement(3149896..3150810) /gene="hag" /locus_tag="BSU_35360" /old_locus_tag="BSU35360" /label="hag gene" downshifts complement(3149916) /Source="Nicolas_upshifts" /id="D1832" /incds=0 /nref=165 /ntot=233 /MaxReadThrough="5.58531" /MaxDrop="7.10921" /score="11.6997504" /energy="-13.1" /TU="U2773" /idTUdmin="U2775" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" S_feature complement(3150811..3150919) /Source="Nicolas_S_feature" /locus_tag="new_3635902_3636010_c" /HighExp="T2.0H, Glucon, M0t90, T2.30H, GM 15, T-0.40H, GM 10, T1.0H, T-1.10H, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1352" promotor_-35 3150877..3150878 /Source="Nicolas_upshift_promotors" /id="U2772" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=717 /SigmaFactorBS="gttaaggcacgtccttgtgcccttattttgtaactggctgaG TcttttgcgCCTCCTCCCGGCTACatcattaatatcggattgtctctgattttgttaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3150887..3150901 /Source="Nicolas_upshift_promotors" /id="U2772" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=717 /SigmaFactorBS="gttaaggcacgtccttgtgcccttattttgtaactggctgaG TcttttgcgCCTCCTCCCGGCTACatcattaatatcggattgtctctgattttgttaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3150896 /Source="Nicolas_upshifts" /id="U2772" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=717 /SigmaFactorBS="gttaaggcacgtccttgtgcccttattttgtaactggctgaG TcttttgcgCCTCCTCCCGGCTACatcattaatatcggattgtctctgattttgttaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3150898..3150916) /Source="Nicolas_upshift_promotors" /id="U2773" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2833 /SigmaFactorBS="cgcattatcctcacaaaaaaagtgaggatttttttatttttg tATTAACAAaatcagagacaaTCCGATATTAATGATGTAGccgggaggaggcgcaaaa g" /listShort="S1352, hag, S1351, yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD" /listLong="S1349, secA, S1348, prfB" /label="promotor_-10" upshifts complement(3150919) /Source="Nicolas_upshifts" /id="U2773" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2833 /SigmaFactorBS="cgcattatcctcacaaaaaaagtgaggatttttttatttttg tATTAACAAaatcagagacaaTCCGATATTAATGATGTAGccgggaggaggcgcaaaa g" /listShort="S1352, hag, S1351, yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD" /listLong="S1349, secA, S1348, prfB" /label="upshifts" promotor_-35 complement(3150929..3150936) /Source="Nicolas_upshift_promotors" /id="U2773" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2833 /SigmaFactorBS="cgcattatcctcacaaaaaaagtgaggatttttttatttttg tATTAACAAaatcagagacaaTCCGATATTAATGATGTAGccgggaggaggcgcaaaa g" /listShort="S1352, hag, S1351, yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD" /listLong="S1349, secA, S1348, prfB" /label="promotor_-35" CDS complement(3150955..3151179) /gene="csrA" /locus_tag="BSU_35370" /old_locus_tag="BSU35370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8982093, 17555441, 21895793, 23144244, 27516547" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8982093, 17555441, 21895793, 23144244, 27516547; Product type r: regulator" /codon_start=1 /transl_table=11 /product="carbon storage regulator" /protein_id="NP_391417.1" /db_xref="EnsemblGenomes-Gn:BSU35370" /db_xref="EnsemblGenomes-Tr:CAB15554" /db_xref="GOA:P33911" /db_xref="InterPro:IPR003751" /db_xref="InterPro:IPR036107" /db_xref="PDB:1T3O" /db_xref="SubtiList:BG10654" /db_xref="UniProtKB/Swiss-Prot:P33911" /translation="MLVLSRKINEAIQIGADIEVKVIAVEGDQVKLGIDAPKHIDIHR KEIYLTIQEENNRAAALSSDVISALSSQKK*" /label="csrA CDS" gene complement(3150955..3151179) /gene="csrA" /locus_tag="BSU_35370" /old_locus_tag="BSU35370" /label="csrA gene" downshifts complement(3150994) /Source="Nicolas_upshifts" /id="D1833" /incds=0 /nref=22 /ntot=171 /MaxReadThrough="2.28652" /MaxDrop="3.46262" /score="31.5820557" /energy="-9.2" /TU="NA" /idTUdmin="U2775" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3151173..3151604) /gene="fliW" /locus_tag="BSU_35380" /old_locus_tag="BSU35380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15033535, 16936039, 21895793, 27516547" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15033535, 16936039, 21895793, 27516547; Product type f: factor" /codon_start=1 /transl_table=11 /product="assembly factor of the flagellum" /protein_id="NP_391418.1" /db_xref="EnsemblGenomes-Gn:BSU35380" /db_xref="EnsemblGenomes-Tr:CAB15555" /db_xref="GOA:P96503" /db_xref="InterPro:IPR003775" /db_xref="InterPro:IPR024046" /db_xref="SubtiList:BG12451" /db_xref="UniProtKB/Swiss-Prot:P96503" /translation="MIIHTKYHGQMNIKEEQIILFESGIPGFLEEKQFVILPLSEDSP FVALQSVTSENLAFIVVSPFIFFKNYEFDLDESTAELLDIDNIQDVEVMTILTMAEPF EKSTANLLAPIIVNRKNMMAKQVVLHDSSYTTKHPIGGESC*" /label="fliW CDS" gene complement(3151173..3151604) /gene="fliW" /locus_tag="BSU_35380" /old_locus_tag="BSU35380" /label="fliW gene" CDS complement(3151625..3152200) /gene="yviE" /locus_tag="BSU_35390" /old_locus_tag="BSU35390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391419.1" /db_xref="EnsemblGenomes-Gn:BSU35390" /db_xref="EnsemblGenomes-Tr:CAB15556" /db_xref="SubtiList:BG12450" /db_xref="UniProtKB/Swiss-Prot:P96502" /translation="MQIPRLIMHSVQGKIGLTTTPASLKMEQPQADLEIEQPSAEMEI SVTPGKLTIDQTQAWEELDRKHVFKRIEEAAQQGHEDVMEGIARTAEEGDELMKIENK GNPIASQARRNSEMHQIQLGENYAPSLSRVKIQYTPSQLDVQITPRKPVIQAEPHKPI VEYTPGNVKVDMLQYPDLNIDVEYPKESPEK*" /label="yviE CDS" gene complement(3151625..3152200) /gene="yviE" /locus_tag="BSU_35390" /old_locus_tag="BSU35390" /label="yviE gene" CDS complement(3152247..3153143) /gene="flgL" /locus_tag="BSU_35400" /old_locus_tag="BSU35400" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2407720, 15033535, 17438286, 23874669, 24296669, 24706744; Product type s : structure" /codon_start=1 /transl_table=11 /product="flagellar hook-filament junction protein" /protein_id="NP_391420.1" /db_xref="EnsemblGenomes-Gn:BSU35400" /db_xref="EnsemblGenomes-Tr:CAB15557" /db_xref="GOA:P96501" /db_xref="InterPro:IPR001029" /db_xref="InterPro:IPR013384" /db_xref="SubtiList:BG11936" /db_xref="UniProtKB/Swiss-Prot:P96501" /translation="MRVTQGMIQQNSLRYIGSSYSKLDKLQSQISSGKKISKASDDPV VAMKSLKYNTQLSQVQQYKSNASQAFTWLENTETNITEGIDILSKVRELAVEAQNDTN GEPERQAIGVEVKQLKEQLLNIANTQVNGRYIFNGTNSDKPPVTDNGDGTYTISDTAD VVVNISNNMSLKVNSDPKSAFGGTSESGQNVFEMLDSFEKALNSGSLDGMDSVLNDID HFSDGMSAERSDLGARYNRLELVNTRLSAQEETATKVLSDNEDVELEEVITEFIAQQS VHRATLAVNAQIVQPTLIDFLK*" /label="flgL CDS" gene complement(3152247..3153143) /gene="flgL" /locus_tag="BSU_35400" /old_locus_tag="BSU35400" /label="flgL gene" downshifts complement(3152270) /Source="Nicolas_upshifts" /id="D1834" /incds=0 /nref=112 /ntot=251 /MaxReadThrough="5.50861" /MaxDrop="3.8234" /score="0.376587888" /energy="-4.8" /TU="U2775,U2776,U2777" /idTUdmin="U2777" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" misc_feature 3152559..3152562 /Source="Nicolas_upshift_promotors" /id="U2774" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.97902097902098" /psig="0.000999000999001" /xcortree=54 /SigmaFactorBS="actgtccatgccatctagcgaaccagaatttagtgctttctc aaaagaatcAAGCatttcaaatacattctgcccgctttcagaagtgcctccaaaagct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3152568 /Source="Nicolas_upshifts" /id="U2774" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.97902097902098" /psig="0.000999000999001" /xcortree=54 /SigmaFactorBS="actgtccatgccatctagcgaaccagaatttagtgctttctc aaaagaatcAAGCatttcaaatacattctgcccgctttcagaagtgcctccaaaagct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3153154..3154677) /gene="flgK" /locus_tag="BSU_35410" /old_locus_tag="BSU35410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2407720, 15033535, 17438286, 23874669, 24296669, 24706744; Product type s : structure" /codon_start=1 /transl_table=11 /product="flagellar hook-filament junction" /protein_id="NP_391421.1" /db_xref="EnsemblGenomes-Gn:BSU35410" /db_xref="EnsemblGenomes-Tr:CAB15558" /db_xref="GOA:P39810" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR002371" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10401" /db_xref="UniProtKB/Swiss-Prot:P39810" /translation="MTSTFMGLETARRALSAQQAALSTTANNVANANTDGYTRQRVSL EATDYFPAVSKNAEKTAGQMGTGVQGKSVERIRDIFLDYQYRLQNNSAGYYDTKAKAL SQMEGVLNETDDSGLNSVLNSFWNSLQELSNNTNEESARSVVARKGQAVAETFNYISE SLTNVQSNLKAELNTTVLDVNSLLSQLNSLNKQIAQVEPVGLLPNGLYDQRDLLIDKL SSMVDIKVSYNKSGGNALASAEGTVSIEILDKNKQSLGTVLDGKNYEVSELAANYDNE TGLVSSISIGDTAVQAESFSSKGSLLGFIESYGYITADGQEKGVYPEMLSDLDNMALE FAKAFNEVHRNGVTKSGEQGGDFFDFTGGETEPAKGAAGKIKVADSIIDSKGANIAFS LTGAANDNANATKLANVLTGKITINGKETSVLDYYAGLIGELGIEAQEANRLASNTET QLNDADINRQQMSAVSLDEEMTNMIQFQHAYNAAARMVTLQDELLDKVINGMGVGGR* " /label="flgK CDS" gene complement(3153154..3154677) /gene="flgK" /locus_tag="BSU_35410" /old_locus_tag="BSU35410" /label="flgK gene" CDS complement(3154696..3155178) /gene="flgN" /locus_tag="BSU_35420" /old_locus_tag="BSU35420" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:24706744" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24706744; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for flagellar based motility" /protein_id="NP_391422.1" /db_xref="EnsemblGenomes-Gn:BSU35420" /db_xref="EnsemblGenomes-Tr:CAB15559" /db_xref="GOA:P39808" /db_xref="InterPro:IPR007809" /db_xref="InterPro:IPR036679" /db_xref="SubtiList:BG10400" /db_xref="UniProtKB/Swiss-Prot:P39808" /translation="MSAKAIIEQLKRLCVLHEHLLTLSEEKTEALKAGKTKELSNILT KEQKYIQAITQTEDDRIKTTSAFLGYSENNTISACIAKTSGSEKEELEQLYESLSQVL GRLKKVNEMNRQLTRDALQFISISYDMLVPKENNFNYSKSIKAELPKSSKMKLFDSKA *" /label="flgN CDS" gene complement(3154696..3155178) /gene="flgN" /locus_tag="BSU_35420" /old_locus_tag="BSU35420" /label="flgN gene" CDS complement(3155194..3155460) /gene="flgM" /locus_tag="BSU_35430" /old_locus_tag="BSU35430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10207036, 10322161, 14762011, 16673084, 21736639, 22720735, 25313396" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10207036, 10322161, 14762011, 16673084, 21736639, 22720735, 25313396; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma factor repressor of sigma(D)-dependent transcription" /protein_id="NP_391423.1" /db_xref="EnsemblGenomes-Gn:BSU35430" /db_xref="EnsemblGenomes-Tr:CAB15560" /db_xref="GOA:P39809" /db_xref="InterPro:IPR007412" /db_xref="InterPro:IPR031316" /db_xref="InterPro:IPR035890" /db_xref="SubtiList:BG10399" /db_xref="UniProtKB/Swiss-Prot:P39809" /translation="MKINQFGTQSVNPYQKNYDKQAVQKTVAQPQDKIEISSQAKEMQ HASDAVTGSRQEKIAQLKAQIENGSYKVDANHIAKNMINFYKKQ*" /label="flgM CDS" gene complement(3155194..3155460) /gene="flgM" /locus_tag="BSU_35430" /old_locus_tag="BSU35430" /label="flgM gene" S_feature complement(3155461..3155540) /Source="Nicolas_S_feature" /locus_tag="new_3640552_3640631_c" /HighExp="T0.30H, Cold, C90, T-5.40H, T-4.40H, GM 150, T-2.40H, GM 45, S2, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigA" /TUshortPSig="1, 1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1353" CDS complement(3155541..3155960) /gene="yvyF" /locus_tag="BSU_35440" /old_locus_tag="BSU35440" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9696775; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator of flagella formation" /protein_id="NP_391424.1" /db_xref="EnsemblGenomes-Gn:BSU35440" /db_xref="EnsemblGenomes-Tr:CAB15561" /db_xref="GOA:P39807" /db_xref="InterPro:IPR022258" /db_xref="SubtiList:BG10398" /db_xref="UniProtKB/Swiss-Prot:P39807" /translation="MGELANCPKCNALFLKTKLQTVCQACIKEEEKSFETVYKFLRKQ ENRQSTLSRITEETGVEEELILKFIRQKRIQITHLPNLAYPCERCGTSIREGKFCKAC QSDIKDQMDHLNHEDALKIEKENSKKDTYYAYNTKNS*" /label="yvyF CDS" gene complement(3155541..3155960) /gene="yvyF" /locus_tag="BSU_35440" /old_locus_tag="BSU35440" /label="yvyF gene" promotor_-10 complement(3155999..3156017) /Source="Nicolas_upshift_promotors" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3156010) /Source="Nicolas_upshifts" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3156031..3156038) /Source="Nicolas_upshift_promotors" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3156034..3156756) /gene="comFC" /locus_tag="BSU_35450" /old_locus_tag="BSU35450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045879, 8412657, 16009133, 28618091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045879, 8412657, 16009133, 28618091; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the DNA transport apparatus" /protein_id="NP_391425.2" /db_xref="EnsemblGenomes-Gn:BSU35450" /db_xref="EnsemblGenomes-Tr:CAB15562" /db_xref="GOA:P39147" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005222" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10397" /db_xref="UniProtKB/Swiss-Prot:P39147" /translation="MSNEAGGGIHKLICLLCDSQFSQDVTWRALFLLKPDEKVCYSCR SKLKKITGHICPLCGRPQSVHAVCRDCEVWRTRIRDSLLLRQNRSVYTYNDMMKETLS RFKFRGDAEIINAFKSDFSSTFSKVYPDKHFVLVPIPLSKEREEERGFNQAHLLAECL DRPSHHPLIRLNNEKQSKKKKTERLLSECIFDTKNNSAEGMNIILIDDLYTTGATLHF AARCLLEKGKAASVSSFTLIRS*" /label="comFC CDS" gene complement(3156034..3156756) /gene="comFC" /locus_tag="BSU_35450" /old_locus_tag="BSU35450" /label="comFC gene" CDS complement(3156720..3157016) /gene="comFB" /locus_tag="BSU_35460" /old_locus_tag="BSU35460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045879, 8412657, 16009133, 25423369" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045879, 8412657, 16009133, 25423369; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of competence, pole located" /protein_id="NP_391426.1" /db_xref="EnsemblGenomes-Gn:BSU35460" /db_xref="EnsemblGenomes-Tr:CAB15563" /db_xref="GOA:P39146" /db_xref="InterPro:IPR019657" /db_xref="PDB:4WAI" /db_xref="SubtiList:BG10396" /db_xref="UniProtKB/Swiss-Prot:P39146" /translation="MLVNSKEIVMKELLDRYMDQLHMACTCQVCQNDVLALSLNKVSP SYVTDFKKIAYTKAELVDKQKNTAMLVILAESAAVVSESPSDLCQTKQEEAFIN*" /label="comFB CDS" gene complement(3156720..3157016) /gene="comFB" /locus_tag="BSU_35460" /old_locus_tag="BSU35460" /label="comFB gene" promotor_-10 complement(3157042..3157061) /Source="Nicolas_upshift_promotors" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3157055) /Source="Nicolas_upshifts" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3157072..3157079) /Source="Nicolas_upshift_promotors" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3157076..3158467) /gene="comFA" /locus_tag="BSU_35470" /old_locus_tag="BSU35470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045895, 11359569, 12123453, 16009133, 21397556, 28559293" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045895, 11359569, 12123453, 16009133, 21397556, 28559293; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent helicase competence protein" /protein_id="NP_391427.1" /db_xref="EnsemblGenomes-Gn:BSU35470" /db_xref="EnsemblGenomes-Tr:CAB15564" /db_xref="GOA:P39145" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10395" /db_xref="UniProtKB/Swiss-Prot:P39145" /translation="MNVPVEKNSSFSKELQQTLRSRHLLRTELSFSDEMIEWHIKNGY ITAENSISINKRRYRCNRCGQTDQRYFSFYHSSGKNKLYCRSCVMMGRVSEEVPLYSW KEENESNWKSIKLTWDGKLSSGQQKAANVLIEAISKKEELLIWAVCGAGKTEMLFPGI ESALNQGLRVCIATPRTDVVLELAPRLKAAFQGADISALYGGSDDKGRLSPLMISTTH QLLRYKDAIDVMIIDEVDAFPYSADQTLQFAVQKARKKNSTLVYLSATPPKELKRKAL NGQLHSVRIPARHHRKPLPEPRFVWCGNWKKKLNRNKIPPAVKRWIEFHVKEGRPVFL FVPSVSILEKAAACFKGVHCRTASVHAEDKHRKEKVQQFRDGQLDLLITTTILERGVT VPKVQTGVLGAESSIFTESALVQIAGRTGRHKEYADGDVIYFHFGKTKSMLDARKHIK EMNELAAKVECTD*" /label="comFA CDS" gene complement(3157076..3158467) /gene="comFA" /locus_tag="BSU_35470" /old_locus_tag="BSU35470" /label="comFA gene" promotor_-10 complement(3158481..3158500) /Source="Nicolas_upshift_promotors" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3158496) /Source="Nicolas_upshifts" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3158514..3158521) /Source="Nicolas_upshift_promotors" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3158573..3159418) /gene="fakBA" /locus_tag="BSU_35480" /old_locus_tag="BSU35480" /EC_number="2.7.2.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3926750, 17114254, 19390149, 22720735, 25002480, 26774272, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3926750, 17114254, 19390149, 22720735, 25002480, 26774272, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid kinase fatty acid binding subunit A" /protein_id="NP_391428.1" /db_xref="EnsemblGenomes-Gn:BSU35480" /db_xref="EnsemblGenomes-Tr:CAB15565" /db_xref="GOA:P32436" /db_xref="InterPro:IPR003797" /db_xref="PDB:3FYS" /db_xref="SubtiList:BG10394" /db_xref="UniProtKB/Swiss-Prot:P32436" /translation="MNIAVVTDSTAYIPKEMREQHQIHMIPLQVVFREETYREEIELD WKSFYEEVKKHNELPTTSQPPIGELVALYEELGKSYDAVISIHLSSGISGTFSSAAAA DSMVDNIDVYPFDSEISCLAQGFYALKAAELIKNGASSPEDIIKELEEMKKTVRAYFM VDDLAHLQRGGRLSSAQAFIGSLLKVKPILHFDNKVIVPFEKIRTRKKAISRIYELLD EDASKGLPMRAAVIHANREEEAAKIIEELSAKYPHVEFYNSYFGAVIGTHLGEGALGI CWCFK*" /label="fakBA CDS" gene complement(3158573..3159418) /gene="fakBA" /locus_tag="BSU_35480" /old_locus_tag="BSU35480" /label="fakBA gene" downshifts complement(3158584) /Source="Nicolas_upshifts" /id="D1835" /incds=0 /nref=207 /ntot=249 /MaxReadThrough="2.43976" /MaxDrop="5.65998" /score="25.7738948" /energy="-9.9" /TU="NA" /idTUdmin="U2779" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3158835..3158842 /Source="Nicolas_upshift_promotors" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3158856..3158875 /Source="Nicolas_upshift_promotors" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3158866..3160598 /Source="Nicolas_S_feature" /locus_tag="new_3643957_3645689" /HighExp="C30, S2, C90, Pyr, T0.30H, GM 150, G/S, T-4.40H, T-3.40H, T1.30H" /AntisenseName="degU" /AntisenseCor="1.0564647169900101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1354" upshifts 3158866 /Source="Nicolas_upshifts" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3159445..3159464) /Source="Nicolas_upshift_promotors" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3159464) /Source="Nicolas_upshifts" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3159479..3159482) /Source="Nicolas_upshift_promotors" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3159516..3160205) /gene="degU" /locus_tag="BSU_35490" /old_locus_tag="BSU35490" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766; Product type r : regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_391429.1" /db_xref="EnsemblGenomes-Gn:BSU35490" /db_xref="EnsemblGenomes-Tr:CAB15566" /db_xref="GOA:P13800" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10393" /db_xref="UniProtKB/Swiss-Prot:P13800" /translation="MTKVNIVIIDDHQLFREGVKRILDFEPTFEVVAEGDDGDEAARI VEHYHPDVVIMDINMPNVNGVEATKQLVELYPESKVIILSIHDDENYVTHALKTGARG YLLKEMDADTLIEAVKVVAEGGSYLHPKVTHNLVNEFRRLATSGVSAHPQHEVYPEIR RPLHILTRRECEVLQMLADGKSNRGIGESLFISEKTVKNHVSNILQKMNVNDRTQAVV VAIKNGWVEMR*" /label="degU CDS" gene complement(3159516..3160205) /gene="degU" /locus_tag="BSU_35490" /old_locus_tag="BSU35490" /label="degU gene" downshifts complement(3159530) /Source="Nicolas_upshifts" /id="D1836" /incds=0 /nref=178 /ntot=235 /MaxReadThrough="5.12878" /MaxDrop="6.38336" /score="20.9249268" /energy="-12.8" /TU="U2781" /idTUdmin="U2779" /TUdmin="-946" /isTUend="FALSE" /label="downshifts" S_feature complement(3160206..3160287) /Source="Nicolas_S_feature" /locus_tag="new_3645297_3645378_c" /HighExp="M40t90, Lbtran, M0t90, LBGtran, G180, T3.0H, M40t45, C90, T3.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1355" CDS complement(3160288..3161445) /gene="degS" /locus_tag="BSU_35500" /old_locus_tag="BSU35500" /EC_number="2.7.3.-" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [DegU]" /protein_id="NP_391430.1" /db_xref="EnsemblGenomes-Gn:BSU35500" /db_xref="EnsemblGenomes-Tr:CAB15567" /db_xref="GOA:P13799" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR008595" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR016381" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10392" /db_xref="UniProtKB/Swiss-Prot:P13799" /translation="MNKTKMDSKVLDSILMKMLKTVDGSKDEVFQIGEQSRQQYEQLV EELKQIKQQVYEVIELGDKLEVQTRHARNRLSEVSRNFHRFSEEEIRNAYEKAHKLQV ELTMIQQREKQLRERRDDLERRLLGLQEIIERSESLVSQITVVLNYLNQDLREVGLLL ADAQAKQDFGLRIIEAQEEERKRVSREIHDGPAQMLANVMMRSELIERIFRDRGAEDG FQEIKNLRQNVRNALYEVRRIIYDLRPMALDDLGLIPTLRKYLYTTEEYNGKVKIHFQ CIGETEDQRLAPQFEVALFRLAQEAVSNALKHSESEEITVKVEITKDFVILMIKDNGK GFDLKEAKEKKNKSFGLLGMKERVDLLEGTMTIDSKIGLGTFIMIKVPLSL*" /label="degS CDS" gene complement(3160288..3161445) /gene="degS" /locus_tag="BSU_35500" /old_locus_tag="BSU35500" /label="degS gene" S_feature complement(3161446..3161573) /Source="Nicolas_S_feature" /locus_tag="new_3646537_3646664_c" /HighExp="T0.30H, Lbtran, M9-stat, T3.0H, T1.0H, HiOs, T1.30H, T2.30H, T3.30H, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1356" promotor_-35 3161493..3161496 /Source="Nicolas_upshift_promotors" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3161511..3161530 /Source="Nicolas_upshift_promotors" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3161522..3161608 /Source="Nicolas_S_feature" /locus_tag="new_3646613_3646699" /HighExp="UNK1, Cold, C30, Lbexp, MG 15, G135, G180, G150, Paraq, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1357" upshifts 3161522 /Source="Nicolas_upshifts" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3161567..3161586) /Source="Nicolas_upshift_promotors" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3161573) /Source="Nicolas_upshifts" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3161590..3161598 /Source="Nicolas_upshift_promotors" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3161597..3161604) /Source="Nicolas_upshift_promotors" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3161610 /Source="Nicolas_upshifts" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3161612..3161620 /Source="Nicolas_upshift_promotors" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3161662..3162315 /gene="yvyE" /locus_tag="BSU_35510" /old_locus_tag="BSU35510" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11116084, 15103642, 21239490, 22404850; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative translation regulator" /protein_id="NP_391431.1" /db_xref="EnsemblGenomes-Gn:BSU35510" /db_xref="EnsemblGenomes-Tr:CAB15568" /db_xref="InterPro:IPR001498" /db_xref="InterPro:IPR015269" /db_xref="InterPro:IPR015796" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020569" /db_xref="InterPro:IPR023582" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR036956" /db_xref="SubtiList:BG11052" /db_xref="UniProtKB/Swiss-Prot:P32437" /translation="MLHSYFTVKEAGEHEIVIEKSRFICHLSRVSTEQEAQEFIQKIK KQHWNATHNCSAYVIGENDHIQKANDDGEPSGTAGVPMLEVLKKRRLKDTCAVVTRYF GGIKLGAGGLIRAYGKSVSEGLNHIGVVERKLMRIMHTSADYTWLGKIENELRESQFL LKEIHYSENVEFETYVEEKETNAFSEWMTELTNGKSDIKEGELTYLEKAVNHIKETE* " /label="yvyE CDS" gene 3161662..3162315 /gene="yvyE" /locus_tag="BSU_35510" /old_locus_tag="BSU35510" /label="yvyE gene" S_feature complement(3162018..3162610) /Source="Nicolas_S_feature" /locus_tag="new_3647109_3647701_c" /HighExp="Etha, M9-stat, Gly, C30, B60, Salt, T0.30H, Sw, LoTm, S8" /AntisenseName="yvyE" /AntisenseCor="-0.139956338862644" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1358" CDS 3162315..3163490 /gene="tagV" /locus_tag="BSU_35520" /old_locus_tag="BSU35520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19099556, 29107701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19099556, 29107701; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid-peptidoglycan tethering enzyme (LCP component) with transcription regulator domain" /protein_id="NP_391432.1" /db_xref="EnsemblGenomes-Gn:BSU35520" /db_xref="EnsemblGenomes-Tr:CAB15569" /db_xref="GOA:P96499" /db_xref="InterPro:IPR004474" /db_xref="PDB:3NXH" /db_xref="SubtiList:BG12449" /db_xref="UniProtKB/Swiss-Prot:P96499" /translation="MAERVRVRVRKKKKSKRRKILKRIMLLFALALLVVVGLGGYKLY KTINAADESYDALSRGNKSNLRNEVVDMKKKPFSILFMGIEDYATKGQKGRSDSLIVV TLDPKNKTMKMLSIPRDTRVQLAGDTTGSKTKINAAYSKGGKDETVETVENFLQIPID KYVTVDFDGFKDVINEVGGIDVDVPFDFDEKSDVDESKRIYFKKGEMHLNGEEALAYA RMRKQDKRGDFGRNDRQKQILNALIDRMSSASNIAKIDKIAEKASENVETNIRITEGL ALQQIYSGFTSKKIDTLSITGSDLYLGPNNTYYFEPDATNLEKVRKTLQEHLDYTPDT STGTSGTEDGTDSSSSSGSTGSTGTTTDGTTNGSSYSNDSSTSSNNSTTNSTTDSSY* " /label="tagV CDS" gene 3162315..3163490 /gene="tagV" /locus_tag="BSU_35520" /old_locus_tag="BSU35520" /label="tagV gene" promotor_-10 complement(3162606..3162624) /Source="Nicolas_upshift_promotors" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3162615) /Source="Nicolas_upshifts" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3162638..3162644) /Source="Nicolas_upshift_promotors" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3163462 /Source="Nicolas_upshifts" /id="D1837" /incds=0 /nref=199 /ntot=276 /MaxReadThrough="2.38202" /MaxDrop="7.1642" /score="16.6000843" /energy="-18.6" /TU="NA" /idTUdmin="U2782" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(3163563..3164639) /gene="tagO" /locus_tag="BSU_35530" /old_locus_tag="BSU35530" /EC_number="2.7.8.33" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12101296, 12682299, 15849754, 16850406, 17012386, 18156271, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12101296, 12682299, 15849754, 16850406, 17012386, 18156271, 27312048; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine:undecaprenyl-P N-acetylglucosaminyl-1-P transferase" /protein_id="NP_391433.1" /db_xref="EnsemblGenomes-Gn:BSU35530" /db_xref="EnsemblGenomes-Tr:CAB15570" /db_xref="GOA:O34753" /db_xref="InterPro:IPR000715" /db_xref="InterPro:IPR018480" /db_xref="SubtiList:BG12684" /db_xref="UniProtKB/Swiss-Prot:O34753" /translation="MLDERMIRIVVAFIVSLLTVLIITPIVKRIAIKIGAVDQPSNRK VHDKIMPRMGGLAIFIGVVAGVLASGIYTETRMTAITVGAFIIIVLGILDDKYQLSAK VKFLIQLGVAIMIVSTGLKMDFFSVPFLTERFELGWMAYPLTVLWIVGITNAINLIDG LDGLAAGLSVIGLSTIAVMALSGGKVLILSLSLVVIASTLGFLFYNFHPAKIFMGDTG SLFLGYSISILSLLGLYKSVTLFSIVIPIIILGVPIFDTTFAIIRRILNKQPISAPDK SHIHHRLMAFGLSHRMSVLVIYLIGFIFSISAIVLKSATIWLSLFIIFILIIFMQIIA EVTGLVNEKFKPFTKFYKRLVKRN*" /label="tagO CDS" gene complement(3163563..3164639) /gene="tagO" /locus_tag="BSU_35530" /old_locus_tag="BSU35530" /label="tagO gene" downshifts complement(3163579) /Source="Nicolas_upshifts" /id="D1838" /incds=0 /nref=221 /ntot=280 /MaxReadThrough="1.7614" /MaxDrop="8.41647" /score="29.109706" /energy="-11.6" /TU="NA" /idTUdmin="U2785" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 3163625..3163634 /Source="Nicolas_upshift_promotors" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3163648..3163667 /Source="Nicolas_upshift_promotors" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3163656..3164889 /Source="Nicolas_S_feature" /locus_tag="new_3648747_3649980" /HighExp="S8, S6, S7, S5, BT, S4, B36, Pyr, S3, G/S" /AntisenseName="tagO" /AntisenseCor="-0.60515751332040901" /AntisenseRegPval="-27.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1359" upshifts 3163656 /Source="Nicolas_upshifts" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3164640..3164722) /Source="Nicolas_S_feature" /locus_tag="new_3649731_3649813_c" /HighExp="LPhT, Cold, LoTm, T0.30H, T3.0H, LBGstat, T1.30H, T1.0H, T2.30H, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.67123699999999997" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.018" /TUlongSig="NA" /TUlongPSig="NA" /label="S1360" promotor_-10 complement(3164710..3164729) /Source="Nicolas_upshift_promotors" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3164722) /Source="Nicolas_upshifts" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3164741..3164747) /Source="Nicolas_upshift_promotors" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3164784..3165977) /gene="tuaH" /locus_tag="BSU_35540" /old_locus_tag="BSU35540" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391434.1" /db_xref="EnsemblGenomes-Gn:BSU35540" /db_xref="EnsemblGenomes-Tr:CAB15571" /db_xref="GOA:O32267" /db_xref="SubtiList:BG12695" /db_xref="UniProtKB/Swiss-Prot:O32267" /translation="METKEAIIHVIVATAEWGKDQLRYRRHRLAEFLAAQEETKEVIW VCPAPRAQGKEFQEVHSGIRQFAVKDLLQKKMFRFGRYTDVFYRHKLSPLLDELTPAS ANGERCCLWYTFPGFPLLSSLYSWDQVIYDCSDLWAAPISGRSNLLSEFRRKVIKSAE LRIIQRADSITCSSDYLHKEVDKKLTAGREKVHTVENGVEYELFSANKQAPDRSILQG REGIVLGFIGGIKPKLDFKMIKEAALQKPDWTFLWVGPDATNGDVSFQELLRLPNVIW TGPADPKEVPHYMELIDIGIMPYKQSPYNQAVFPLKLFEFLAAGKPVVGTNLPSTSKM QKPYVYEYVEGDHPIDFIAACEKVLGQNGDETYKEMRRNIARTQDWNCLFRQIMKYTG IQKHA*" /label="tuaH CDS" gene complement(3164784..3165977) /gene="tuaH" /locus_tag="BSU_35540" /old_locus_tag="BSU35540" /label="tuaH gene" downshifts complement(3164814) /Source="Nicolas_upshifts" /id="D1839" /incds=0 /nref=23 /ntot=141 /MaxReadThrough="7.20583" /MaxDrop="4.88676" /score="4.72365619" /energy="-10.8" /TU="U2786" /idTUdmin="U2785" /TUdmin="-1236" /isTUend="FALSE" /label="downshifts" CDS complement(3166006..3166764) /gene="tuaG" /locus_tag="BSU_35550" /old_locus_tag="BSU35550" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391435.1" /db_xref="EnsemblGenomes-Gn:BSU35550" /db_xref="EnsemblGenomes-Tr:CAB15572" /db_xref="GOA:O32268" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12694" /db_xref="UniProtKB/Swiss-Prot:O32268" /translation="MTNWKPLVSVITPSYNARDYIEDTVHSVLDQSHPHWEMIIVDDC STDGTRDILQQYEKIDERIHVVYLEENSGAAVARNKALERAQGRYVAFLDSDDKWKKD KLEKQLEFMMERSCAFSFTGYSLMAQDGTPLDKFIHAPESLTYDDALKNTIIGCLTVM IDREQTGQIQMPNIRTRQDLATWLSLLKKGFTAYGMNECLAEYRLVNNSISSNKWKAA KKTWFVYREIERLHFMKATWCFVQYAKNAVKKRL*" /label="tuaG CDS" gene complement(3166006..3166764) /gene="tuaG" /locus_tag="BSU_35550" /old_locus_tag="BSU35550" /label="tuaG gene" CDS complement(3166788..3167468) /gene="tuaF" /locus_tag="BSU_35560" /old_locus_tag="BSU35560" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase involved in teichuronic acid synthesis" /protein_id="NP_391436.1" /db_xref="EnsemblGenomes-Gn:BSU35560" /db_xref="EnsemblGenomes-Tr:CAB15573" /db_xref="GOA:O32269" /db_xref="InterPro:IPR003856" /db_xref="SubtiList:BG12693" /db_xref="UniProtKB/Swiss-Prot:O32269" /translation="MNDILIRIARRIKKNIIWIIAVPIILGAAGYILPSQIADQKSYT AEDTLAVGSYDHPVYNSTEEIPLLLKSDSFLKEALPDEKDEDVAEIKEKLTINTESKS LLTLSYSDEDKDRTESVLNAISSTFLKNDQKLYAEREAVIRSSIDALEGESVSEDSKV DKERFLYELKNTQLNLKAASVTDSETVSETAGGGMSPKKKAVLGVMIGLTIAFMFVVI PEFFRESF*" /label="tuaF CDS" gene complement(3166788..3167468) /gene="tuaF" /locus_tag="BSU_35560" /old_locus_tag="BSU35560" /label="tuaF gene" CDS complement(3167497..3168963) /gene="tuaE" /locus_tag="BSU_35570" /old_locus_tag="BSU35570" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 15849754, 16850406, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative polymerase of teichuronic acid repeating units" /protein_id="NP_391437.1" /db_xref="EnsemblGenomes-Gn:BSU35570" /db_xref="EnsemblGenomes-Tr:CAB15574" /db_xref="GOA:O32270" /db_xref="InterPro:IPR007016" /db_xref="SubtiList:BG12692" /db_xref="UniProtKB/Swiss-Prot:O32270" /translation="MSIKRSAVHTLALLAAAIFGVVLLLGAIHKDIGFMQMAAVLAVL AIGLFLLTLATAFTTKERLFMAVIYILIACTFLNNAFFAIHLGFFSLFLYRLLLIAAG CLHIFGMVRNRTHIERWHGLQVKGILLFFAFWFIYGLVSLLWAKSVTVGLKYLALLAM GIFFIYLIVMYVQKMERLMIVYAIWLVMTVFLMIIGFYNHITHHHLASSTLYSGPEYK QHYPTSVFFNQNDFATFLSISFFFYITMMKNIKNGYIKAIGLVLSLCALYLIFATGSR ASLLGIFAGIAVYIFIVLPPVLKRMAIWLSAAGIALFAVLFASKIYSKFWELFLAPQT LHSFHDRLPSNVARANLLKNAWHFFLDSYGFGVGAGNVSYYLEHYAVYDTDNVAEVHN WLVEILANFGLFIMLGYLSVYAYLIWVLYKFYERKLENQSKLITEGLITAMVSFLVSS ISPSSVSNLFFHWVFMALVIAAVNVLRRSRQMPEPMYR*" /label="tuaE CDS" gene complement(3167497..3168963) /gene="tuaE" /locus_tag="BSU_35570" /old_locus_tag="BSU35570" /label="tuaE gene" S_feature complement(3168964..3169047) /Source="Nicolas_S_feature" /locus_tag="new_3654055_3654138_c" /HighExp="LPhT, S3, B60, S7, S4, S6, LBGstat, BI, S8, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.018" /TUlongSig="NA" /TUlongPSig="NA" /label="S1361" CDS complement(3169048..3170433) /gene="tuaD" /locus_tag="BSU_35580" /old_locus_tag="BSU35580" /EC_number="1.1.1.22" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10376820, 10913081, 12970183, 16000785, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10376820, 10913081, 12970183, 16000785, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose 6-dehydrogenase (teichuronic acid)" /protein_id="NP_391438.1" /db_xref="EnsemblGenomes-Gn:BSU35580" /db_xref="EnsemblGenomes-Tr:CAB15575" /db_xref="GOA:O32271" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR021157" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12691" /db_xref="UniProtKB/Swiss-Prot:O32271" /translation="MKKIAVIGTGYVGLVSGTCFAEIGNKVVCCDIDESKIRSLKNGV IPIYEPGLADLVEKNVLDQRLTFTNDIPSAIRASDIIYIAVGTPMSKTGEADLTYVKA AAKTIGEHLNGYKVIVNKSTVPVGTGKLVQSIVQKASKGRYSFDVVSNPEFLREGSAI HDTMNMERAVIGSTSHKAAAIIEELHQPFHAPVIKTNLESAEMIKYAANAFLATKISF INDIANICERVGADVSKVADGVGLDSRIGRKFLKAGIGFGGSCFPKDTTALLQIAKSA GYPFKLIEAVIETNEKQRVHIVDKLLTVMGSVKGRTISVLGLAFKPNTNDVRSAPALD IIPMLQQLGAHVKAYDPIAIPEASAILGEQVEYYTDVYAAMEDTDACLILTDWPEVKE MELVKVKTLLKQPVIIDGRNLFSLEEMQAAGYIYHSIGRPAVRGTEPSDKYFPGLPLE ELAKDLGSVNL*" /label="tuaD CDS" gene complement(3169048..3170433) /gene="tuaD" /locus_tag="BSU_35580" /old_locus_tag="BSU35580" /label="tuaD gene" CDS complement(3170495..3171664) /gene="tuaC" /locus_tag="BSU_35590" /old_locus_tag="BSU35590" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391439.1" /db_xref="EnsemblGenomes-Gn:BSU35590" /db_xref="EnsemblGenomes-Tr:CAB15576" /db_xref="GOA:O32272" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG12690" /db_xref="UniProtKB/Swiss-Prot:O32272" /translation="MKILWITSVYPSSMKPGEGVFHETQVQELQKLGLDITVICPRPF HSAPVRMLKKTYRKKDVRPEYEIRKGIPVYRPFYRAVPGQLKWAQPHRRIASAVLKTM KQRDLYPDLIHAHFAMPSGGAAAVVSESAQIPYVLTLHGSDVNVYPHYSKGAFKAFKR AVGSASVVLAVSHKLQEEAKKLSGFDSSVLPIGIQLSRFQGNEETKEEIRKRLGLPLD QRLAVYVGRLVREKGIFELSEAIESLQDSPKAVFVGDGPAKSTLTQKGHIVTGQVPNH QVRDYLLAADLFVLPSYSEGMPTVVIEALALRVPVICTDVGGVSSLFGKHQHLLIKPK SAQALAEAITRYEHEQIWKPEVADDLYETVQAQFDAGKNAKALHHQYQTVTKTSV*" /label="tuaC CDS" gene complement(3170495..3171664) /gene="tuaC" /locus_tag="BSU_35590" /old_locus_tag="BSU35590" /label="tuaC gene" CDS complement(3171661..3173112) /gene="tuaB" /locus_tag="BSU_35600" /old_locus_tag="BSU35600" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10048024, 11994144, 15849754, 16850406, 22720735, 26284661; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative exporter involved in biosynthesis of teichuronic acid" /protein_id="NP_391440.1" /db_xref="EnsemblGenomes-Gn:BSU35600" /db_xref="EnsemblGenomes-Tr:CAB15577" /db_xref="GOA:O32273" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG12689" /db_xref="UniProtKB/Swiss-Prot:O32273" /translation="MPSITKQIMSGAKWTSISTMCITIIQIVQFALLGNMMTLTEFGL VGMITTVTVFAQIVLDMGFGAALIQRDDATERQLSTLYWLNIMTGVLLFVLLYVSSPV IAGFYQREELVFLVRILAIMFLIAPIGQQYQYMLQKQLHFNTLSKIEIFSNVLSFGYL AIAVFMMDAILAYVISQVLLQSSKGILYWAVYRKKWHPAFVFDLRGMKDFFSFGAFQL SSRLVNRLGANIDMILIGRFIGAEALGIYNLAYQIVTIPVLKINPIVTRVAFPIFAKN KYENSVIREGFLNMTKMLALVSFPLLIGLVSVSDAFITAVFGEKWLAAVPILNVLAIV GILRVLMNPNGSVLLAKGRADLAFYWDSGVLLLYGLSLFAAVQTGSLLTVAWVYAIIS VVNFLIGRWLLAYVIKLNLSAYFQSIMKPFLITAAMGIIAFGVSLSTEHFSMQAEMRL AISVAAGALCYLFLLVKAYPQTKSKLLRKGRLS*" /label="tuaB CDS" gene complement(3171661..3173112) /gene="tuaB" /locus_tag="BSU_35600" /old_locus_tag="BSU35600" /label="tuaB gene" CDS complement(3173168..3173317) /gene="tuaAc" /locus_tag="BSU_35609" /old_locus_tag="BSU35609" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262, 26284661; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative undecaprenyl-phosphate N-acetylgalactosaminyl-1-phosphate transferase; C-terminal part of TuaA" /db_xref="SubtiList:BG12688" /translation="WAQVNGGYDMTPKEKLIFDLYYIRNLTFTLELKIMLKTCKVVWT GDGAR*" /label="tuaAc CDS" gene complement(3173168..3173317) /gene="tuaAc" /locus_tag="BSU_35609" /old_locus_tag="BSU35609" /pseudo /label="tuaAc gene" CDS complement(3173262..3173801) /gene="tuaAn" /locus_tag="BSU_35610" /old_locus_tag="BSU35610" /EC_number="2.7.8.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 10048024, 11994144, 26284661; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative undecaprenyl-phosphate N-acetylgalactosaminyl-1-phosphate transferase; N-terminal part of TuaA" /translation="MSAEKSMNVSREFSVQQIHSFTLSEKTARYLAIKRVMDIWFALI GLAIALPMIAVFSILICLETPGPAIYTQERVGKGGKPFKLYKLRSMKIDAEKSGAVWA QKQDPRVTRIGAFIRRTRIDELPQLFNVLKGDMSMIGPRPERPVFTEKFQNEIPGFTQ RLGSGERRLRYDAEGKADI*" /label="tuaAn CDS" gene complement(3173262..3173801) /gene="tuaAn" /locus_tag="BSU_35610" /old_locus_tag="BSU35610" /pseudo /label="tuaAn gene" misc_feature complement(3173857..3173874) /Source="Nicolas_upshift_promotors" /id="U2786" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.017982017982018" /xcortree=12 /SigmaFactorBS="cagaaaaaacacgtaattcacacttcttaacataccatttac atccaATTAACATCCGTCTGCTAaactgactggcataggtcatcataacatcccaaac a" /listShort="tuaA, tuaA, tuaB, tuaC, tuaD, S1361, tuaE, tuaF, tuaG, tuaH, S1360, tagO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3173861) /Source="Nicolas_upshifts" /id="U2786" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.017982017982018" /xcortree=12 /SigmaFactorBS="cagaaaaaacacgtaattcacacttcttaacataccatttac atccaATTAACATCCGTCTGCTAaactgactggcataggtcatcataacatcccaaac a" /listShort="tuaA, tuaA, tuaB, tuaC, tuaD, S1361, tuaE, tuaF, tuaG, tuaH, S1360, tagO" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3174028..3175518) /gene="lytC" /locus_tag="BSU_35620" /old_locus_tag="BSU35620" /EC_number="3.5.1.28" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1357079, 9537764, 14594841, 17298895, 19542270, 22469514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 9537764, 14594841, 17298895, 19542270, 22469514; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase (major autolysin)" /protein_id="NP_391442.1" /db_xref="EnsemblGenomes-Gn:BSU35620" /db_xref="EnsemblGenomes-Tr:CAB15579" /db_xref="GOA:Q02114" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR007253" /db_xref="SubtiList:BG10407" /db_xref="UniProtKB/Swiss-Prot:Q02114" /translation="MRSYIKVLTMCFLGLILFVPTALADNSVKRVGGSNRYGTAVQIS KQMYSTASTAVIVGGSSYADAISAAPLAYQKNAPLLYTNSDKLSYETKTRLKEMQTKN VIIVGGTPAVSSNTANQIKSLGISIKRIAGSNRYDTAARVAKAMGATSKAVILNGFLY ADAPAVIPYAAKNGYPILFTNKTSINSATTSVIKDKGISSTVVVGGTGSISNTVYNKL PSPTRISGSNRYELAANIVQKLNLSTSTVYVSNGFSYPDSIAGATLAAKKKQSLILTN GENLSTGARKIIGSKNMSNFMIIGNTPAVSTKVANQLKNPVVGETIFIDPGHGDQDSG AIGNGLLEKEVNLDIAKRVNTKLNASGALPVLSRSNDTFYSLQERVNKAASAQADLFL SIHANANDSSSPNGSETYYDTTYQAANSKRLAEQIQPKLAANLGTRDRGVKTAAFYVI KYSKMPSVLVETAFITNASDASKLKQAVYKDKAAQAIHDGTVSYYR*" /label="lytC CDS" gene complement(3174028..3175518) /gene="lytC" /locus_tag="BSU_35620" /old_locus_tag="BSU35620" /label="lytC gene" downshifts complement(3174050) /Source="Nicolas_upshifts" /id="D1840" /incds=0 /nref=145 /ntot=213 /MaxReadThrough="3.26689" /MaxDrop="6.50948" /score="13.9455176" /energy="-13.3" /TU="NA" /idTUdmin="U2788" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3175557..3177674) /gene="lytB" /locus_tag="BSU_35630" /old_locus_tag="BSU35630" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1357079, 16306698, 17269748" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 16306698, 17269748; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modifier of major autolysin amidase LytC" /protein_id="NP_391443.1" /db_xref="EnsemblGenomes-Gn:BSU35630" /db_xref="EnsemblGenomes-Tr:CAB15580" /db_xref="GOA:Q02113" /db_xref="InterPro:IPR007253" /db_xref="InterPro:IPR013486" /db_xref="InterPro:IPR013693" /db_xref="SubtiList:BG10406" /db_xref="UniProtKB/Swiss-Prot:Q02113" /translation="MKSCKQLIVCSLAAILLLIPSVSFAADSNISVKLLNYIGNKSSI SLSPTGFYKVTGDNVAVTDRFAGASRYETATLASNSQWKNPNTVILVNRDIFIDALPV IPLAKKLNAPVLFTQPDTLTKTTERQIAKFNPDNILIIGGARSISKDVENKLKSYGAV KRISGKNRYVLSENIAKQMGSYDKAIVVTGRVFQDALAIAPYAAAHGYPILLTEKDKL PDYDLPKQVIIIGSSFSVSDSVENQIKKTSTVQRIPGSTRYELTANIIKQLKLKADKV VMTNGTKYADVLIGASLASKKNSQILFVKQDSVPAAAKSITKDKATYAYDFIGSTSSI SAEVENSLADEFYLADGGTYNLKINSGKLNLENIKTYGNSLRIKPENYSTSNRISLDG KQYLGTVNFSIESTKYIRPVNENIPFEDYLKGVIPNEMPASWSLEALKAQTVAARTYS ITKTGTTVPDTTAFQVYGGYSWNSNTNKAVEQTKGKVLKYNGSLITAAYSSSNGGYTE ASNEVWSSSVPYLIAKKDTKDPQIGWTLTLSKQQLDTKSLDLTKPSSWWSSATETDSA RLSGVKNWILKNKETSADSVKIASIDDLSFSGTTQGQRAKTASMKVKYFVKSSTGSYN LSKITTISVPTSELRTMIGATVFKSTYVTVKKDTSKYTISGKGYGHGIGMSQYGAKAR AEAGDSYSSILKFYYPGTTLTSY*" /label="lytB CDS" gene complement(3175557..3177674) /gene="lytB" /locus_tag="BSU_35630" /old_locus_tag="BSU35630" /label="lytB gene" CDS complement(3177698..3178006) /gene="lytA" /locus_tag="BSU_35640" /old_locus_tag="BSU35640" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1357079, 10974124, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 10974124, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="membrane bound lipoprotein" /protein_id="NP_391444.1" /db_xref="EnsemblGenomes-Gn:BSU35640" /db_xref="EnsemblGenomes-Tr:CAB15581" /db_xref="GOA:Q02112" /db_xref="SubtiList:BG10405" /db_xref="UniProtKB/Swiss-Prot:Q02112" /translation="MKKFIALLFFILLLSGCGVNSQKSQGEDVSPDSNIETKEGTYVG LADTHTIEVTVDNEPVSLDITEESTSDLDKFNSGDKVTITYEKNDEGQLLLKDIERAN *" /label="lytA CDS" gene complement(3177698..3178006) /gene="lytA" /locus_tag="BSU_35640" /old_locus_tag="BSU35640" /label="lytA gene" downshifts 3177912 /Source="Nicolas_upshifts" /id="D1841" /incds=1 /nref=1 /ntot=45 /MaxReadThrough="1.03108" /MaxDrop="2.46089" /score="-4.93783022" /energy="-8" /TU="NA" /idTUdmin="U2787" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" promotor_-35 3178002..3178006 /Source="Nicolas_upshift_promotors" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3178015..3178029 /Source="Nicolas_upshift_promotors" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3178016..3178034) /Source="Nicolas_upshift_promotors" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3178022 /Source="Nicolas_upshifts" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3178048..3178055) /Source="Nicolas_upshift_promotors" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3178051) /Source="Nicolas_upshifts" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3178072..3178080 /Source="Nicolas_upshift_promotors" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3178094..3178107 /Source="Nicolas_upshift_promotors" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3178112 /Source="Nicolas_upshifts" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="upshifts" CDS 3178190..3179110 /gene="tagU" /locus_tag="BSU_35650" /old_locus_tag="BSU35650" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1357079, 9636707, 12034833, 19099556, 28197687, 29107701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 9636707, 12034833, 19099556, 28197687, 29107701; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid-peptidoglycan tethering enzyme (LCP component) with transcription regulator domain of major autolysin expression" /protein_id="NP_391445.1" /db_xref="EnsemblGenomes-Gn:BSU35650" /db_xref="EnsemblGenomes-Tr:CAB15582" /db_xref="GOA:Q02115" /db_xref="InterPro:IPR004474" /db_xref="InterPro:IPR023734" /db_xref="SubtiList:BG10404" /db_xref="UniProtKB/Swiss-Prot:Q02115" /translation="MRNERRKKKKTLLLTILTIIGLLVLGTGGYAYYLWHKAASTVAS IHESIDKSKKRDKEVSINKKDPFSVLIMGVDERDGDKGRADTLIYMTVNPKTNTTDMV SIPRDTYTKIIGKGTMDKINHSYAFGGTQMTVDTVENFLDVPVDYFVKVNMESFRDVV DTLGGITVNSTFAFSYDGYSFGKGEITLNGKEALAYTRMRKEDPRGDFGRQDRQRQVI QGIINKGANISSITKFGDMFKVVENNVKTNLTFDNMWDIQSDYKGARKHIKQHELKGT GTKINGIYYYQADESALSDITKELKESLEK*" /label="tagU CDS" gene 3178190..3179110 /gene="tagU" /locus_tag="BSU_35650" /old_locus_tag="BSU35650" /label="tagU gene" downshifts 3179100 /Source="Nicolas_upshifts" /id="D1842" /incds=0 /nref=224 /ntot=261 /MaxReadThrough="0.434639999999999" /MaxDrop="6.11301" /score="-4.93783022" /energy="-8" /TU="NA" /idTUdmin="U2789" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3179150..3180292) /gene="mnaA" /locus_tag="BSU_35660" /old_locus_tag="BSU35660" /EC_number="5.1.3.14" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12107153, 16952950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12107153, 16952950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmannosamine 2-epimerase" /protein_id="NP_391446.1" /db_xref="EnsemblGenomes-Gn:BSU35660" /db_xref="EnsemblGenomes-Tr:CAB15583" /db_xref="GOA:P39131" /db_xref="InterPro:IPR003331" /db_xref="InterPro:IPR029767" /db_xref="PDB:1O6C" /db_xref="PDB:4FKZ" /db_xref="SubtiList:BG10403" /db_xref="UniProtKB/Swiss-Prot:P39131" /translation="MKKLKVMTVFGTRPEAIKMAPLVLELKKYPEIDSYVTVTAQHRQ MLDQVLDAFHIKPDFDLNIMKERQTLAEITSNALVRLDELFKDIKPDIVLVHGDTTTT FAGSLAAFYHQIAVGHVEAGLRTGNKYSPFPEELNRQMTGAIADLHFAPTGQAKDNLL KENKKADSIFVTGNTAIDALNTTVRDGYSHPVLDQVGEDKMILLTAHRRENLGEPMEN MFKAIRRIVGEFEDVQVVYPVHLNPVVREAAHKHFGDSDRVHLIEPLEVIDFHNFAAK SHFILTDSGGVQEEAPSLGKPVLVLRDTTERPEGVEAGTLKLAGTDEENIYQLAKQLL TDPDEYKKMSQASNPYGDGEASRRIVEELLFHYGYRKEQPDSFTGK*" /label="mnaA CDS" gene complement(3179150..3180292) /gene="mnaA" /locus_tag="BSU_35660" /old_locus_tag="BSU35660" /label="mnaA gene" downshifts complement(3179174) /Source="Nicolas_upshifts" /id="D1843" /incds=0 /nref=126 /ntot=236 /MaxReadThrough="0.41249" /MaxDrop="5.56107" /score="7.64930656" /energy="-11" /TU="NA" /idTUdmin="U2790" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3180331..3180350) /Source="Nicolas_upshift_promotors" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3180345) /Source="Nicolas_upshifts" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3180365..3180368) /Source="Nicolas_upshift_promotors" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3180421..3180425 /Source="Nicolas_upshift_promotors" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3180441..3180460 /Source="Nicolas_upshift_promotors" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3180442..3180537 /Source="Nicolas_S_feature" /locus_tag="new_3665533_3665628" /HighExp="C90, dia5, Salt, Lbexp, T1.0H, MG 5, GM 90, MG 45, LoTm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1362" upshifts 3180443 /Source="Nicolas_upshifts" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="upshifts" CDS 3180538..3181416 /gene="gtaB" /locus_tag="BSU_35670" /old_locus_tag="BSU35670" /EC_number="2.7.7.9" /function="16.8: Protect" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2846750, 8126437, 8320212, 9658024, 17662947, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2846750, 8126437, 8320212, 9658024, 17662947, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_391447.1" /db_xref="EnsemblGenomes-Gn:BSU35670" /db_xref="EnsemblGenomes-Tr:CAB15584" /db_xref="GOA:Q05852" /db_xref="InterPro:IPR005771" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10402" /db_xref="UniProtKB/Swiss-Prot:Q05852" /translation="MKKVRKAIIPAAGLGTRFLPATKAMPKEMLPIVDKPTIQYIIEE AVEAGIEDIIIVTGKSKRAIEDHFDYSPELERNLEEKGKTELLEKVKKASNLADIHYI RQKEPKGLGHAVWCARNFIGDEPFAVLLGDDIVQAETPGLRQLMDEYEKTLSSIIGVQ QVPEEETHRYGIIDPLTSEGRRYQVKNFVEKPPKGTAPSNLAILGRYVFTPEIFMYLE EQQVGAGGEIQLTDAIQKLNEIQRVFAYDFEGKRYDVGEKLGFITTTLEFAMQDKELR DQLVPFMEGLLNKEEI*" /label="gtaB CDS" gene 3180538..3181416 /gene="gtaB" /locus_tag="BSU_35670" /old_locus_tag="BSU35670" /label="gtaB gene" S_feature 3181417..3182508 /Source="Nicolas_S_feature" /locus_tag="new_3666508_3667599" /HighExp="Etha, Gly, C30, M9-stat, B60, T1.30H, B36, T1.0H, M40t90, T0.30H" /AntisenseName="yvzH" /AntisenseCor="-0.24043295548020899" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1363" S_feature complement(3181486..3181841) /Source="Nicolas_S_feature" /locus_tag="new_3666577_3666932_c" /HighExp="C30, LPh, HPh, Gly, G135, HiOs, aero, GM 25, MG 25, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.74940200000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD" /TUlongPSig="0.996" /label="S1364" CDS 3181750..3181968 /locus_tag="BSU_35678" /old_locus_tag="BSU35678" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514004.1" /translation="MATILIPLTTLLDLSRIVGLIENHGIKPASIQTIKGTSPIPVMT SLLLRIPNTNQYAIIRIRGFKTCHNTPK*" /label="hypothetical protein CDS" gene 3181750..3181968 /locus_tag="BSU_35678" /old_locus_tag="BSU35678" /label="gene" CDS complement(3181842..3181925) /gene="yvzH" /locus_tag="BSU_35679" /old_locus_tag="BSU35679" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative teichoic acid translocation permease protein tagG (fragment)" /db_xref="PSEUDO:CAX52700.1" /translation="MMAYWFVFGMRNSKLVITGIGEVPFIV*" /label="yvzH CDS" gene complement(3181842..3181925) /gene="yvzH" /locus_tag="BSU_35679" /old_locus_tag="BSU35679" /pseudo /label="yvzH gene" S_feature complement(3181926..3182117) /Source="Nicolas_S_feature" /locus_tag="new_3667017_3667208_c" /HighExp="HPh, LPh, C30, Gly, S0, HiOs, aero, G135, Mal, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1365" CDS complement(3182118..3184820) /gene="ggaB" /locus_tag="BSU_35680" /old_locus_tag="BSU35680" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16735734" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16735734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="poly(glucosyl N-acetylgalactosamine 1-phosphate)glucosyltransferase" /protein_id="NP_391448.1" /db_xref="EnsemblGenomes-Gn:BSU35680" /db_xref="EnsemblGenomes-Tr:CAB15585" /db_xref="GOA:P46918" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR007554" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11192" /db_xref="UniProtKB/Swiss-Prot:P46918" /translation="MNEKSFNYDFSVIMPIYNVELYLTEAIESIINQTIGFENIQLIL VNDDSPDKSEIICKEYAQKYPNNIVYAKKQNGGVSSARNYGLKYAEGRYIQFLDPDDL VSEGTFENVLNFFDEHKNEIDIVAIPIFFAEGRTGEHNLNNKFSSTRILDVEKEPHHI LTHCCSTFIKKDALKNIRFDENCKIGEDAKLVNLIISQKKKYGLVKEAKYHYRVREDG SSAMQTAKANKNWFNHSLITFSKNLIDIIKNHEQKIPLFLQYMVMHDLKWKLLIKDIS ETPLDENEYSEFLTLIREVLSYIDDDVIIETKSVSHFYLYHALKIKHGENYSRYVYER ETEQDYYLYREGKIVSKLSDQTLTIEILEENEDSIHIEGFWSSLFNSKGFKFYAKIGE TKIKAKNIKRQHNDYISLGEVIKKYPGFSIDIPKGHLADNHHIEFFITKGKKRKLTKL RFFKYSGLSNDLYNTYVAKKDYIFYYNYKKLMFKKNNFKNRFIKEFRFLKSLHKSGEK SKKRKSAIKKALMARMVHHVFTIFNRKPVWLFIDRQDKADDNAEHLFKYAINKNDGVK KYFIIKKDSKDYDRIKKYGKVIPYRSFRHKILTLSSSKVISTHADIWVVNPFFNMEIY FRDLFNFEFIFLQHGITMADHSEWLNKYNKNIKLLVTSAKPEYRSIVKGNYNYKKENI LLGGFPRYDNLKKSEGEKQLLIMPTWRKDIVLPKDQAKGVRPYNPKFKDSEYFSRYNA LINDERLIEFAKKNNYKITFFPHPDIQQQIVDFEKHDYVEFADYNSSYQMLFNSSNIM ITDFSSVAFDFAYEKKPVIYYQYEKSYHFKLDYYDYKKMGFGDVLENHNSLVDKVIYY MKNNSRMEDKYRKRVDNFFAYTDKNNRNRIYNAILELDNNKVAK*" /label="ggaB CDS" gene complement(3182118..3184820) /gene="ggaB" /locus_tag="BSU_35680" /old_locus_tag="BSU35680" /label="ggaB gene" S_feature complement(3184821..3184943) /Source="Nicolas_S_feature" /locus_tag="new_3669912_3670034_c" /HighExp="BMM, HiOs, MG 15, C30, SMM, GM 90, HPh, MG 150, MG 25, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1366" promotor_-35 3184842..3184848 /Source="Nicolas_upshift_promotors" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3184863..3184881 /Source="Nicolas_upshift_promotors" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3184868..3187700 /Source="Nicolas_S_feature" /locus_tag="new_3669959_3672791" /HighExp="Sw, LoTm, M9-stat, Salt, B60, T0.30H, Gly, T1.0H, B36, BI" /AntisenseName="ggaA" /AntisenseCor="-0.503651102561819" /AntisenseRegPval="-18" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1367" upshifts 3184868 /Source="Nicolas_upshifts" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3184944..3186284) /gene="ggaA" /locus_tag="BSU_35690" /old_locus_tag="BSU35690" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16735734, 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="poly(glucosyl N-acetylgalactosamine 1-phosphate)glucosyltransferase (missing signal peptide)" /db_xref="EnsemblGenomes-Gn:BSU35690" /db_xref="EnsemblGenomes-Tr:CAB15586" /db_xref="GOA:P46917" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="PSEUDO:CAB15586.1" /db_xref="SubtiList:BG11367" /db_xref="UniProtKB/Swiss-Prot:P46917" /translation="MFSIIIPIYNSENYLRYSIESVLNQSIGFKENIELILIDDGSVD SSPQICESFKNLYPNNIKIMKIENSGPSAARNCGLSNVSERSKFIGFLDSDDAFSQNA LQSVYDFFCDSEHVNIAVLPVYYTGEKEGGHKLNNRFEKGTRVINILNDYKAIHFYIG GTFYRRHTLTSTVLFDESIKFWEDAIFFNQLLLKEKRYGAVAEGKYFYRKRKEQDSLV DRSWFNKKRYTYLLNECYMTLLMDSFNKYDIVLPYLQFLIVYHIKLFLYPNYRDVYKS VLDQQEQRVFVDDFIKVLKFIDPQFIKEQDMPMYYKEFMFHLLKENTEALENIKKERV LHSSCTVTSAKIKGLRLELTGHFINQYYEMKENDRIYIKYFKRLKKCKRKELKKTIEV WGYKLRDFRYAGFVVEIPIWAFAFDFVLKTPNDSLELNHVNIFKSLLTRVFKKR*" /label="ggaA CDS" gene complement(3184944..3186284) /gene="ggaA" /locus_tag="BSU_35690" /old_locus_tag="BSU35690" /pseudo /label="ggaA gene" CDS complement(3186325..3186531) /gene="yvzI" /locus_tag="BSU_35698" /old_locus_tag="BSU35698" /EC_number="2.7.8.12" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase (fragment)" /db_xref="PSEUDO:CAX52701.1" /translation="MYDLPAYRDCIRGFYFNFQQKTPGNLLQTSEELIDTVKELLHNP YIDHNYEDFYNKFCNLEEARLLKE*" /label="yvzI CDS" gene complement(3186325..3186531) /gene="yvzI" /locus_tag="BSU_35698" /old_locus_tag="BSU35698" /pseudo /label="yvzI gene" S_feature complement(3186532..3187405) /Source="Nicolas_S_feature" /locus_tag="new_3671623_3672496_c" /HighExp="HiOs, Heat, BMM, MG 15, GM 90, MG 25, MG 150, C30, GM 25, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99943499999999996" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1368" promotor_-10 complement(3187399..3187418) /Source="Nicolas_upshift_promotors" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3187405) /Source="Nicolas_upshifts" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3187407..3187646) /Source="Nicolas_S_feature" /locus_tag="new_3672498_3672737_c" /HighExp="Cold, LBGstat, C30, GM 25, GM 15, GM 45, GM 60, GM 10, GM-0.2, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1369" promotor_-35 complement(3187431..3187437) /Source="Nicolas_upshift_promotors" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3187628..3187646) /Source="Nicolas_upshift_promotors" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="promotor_-10" upshifts complement(3187646) /Source="Nicolas_upshifts" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="upshifts" promotor_-35 complement(3187660..3187667) /Source="Nicolas_upshift_promotors" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="promotor_-35" promotor_-35 3187669..3187676 /Source="Nicolas_upshift_promotors" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3187688..3187707 /Source="Nicolas_upshift_promotors" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3187702..3187832 /Source="Nicolas_S_feature" /locus_tag="new_3672793_3672923" /HighExp="Sw, T0.30H, LoTm, B60, T1.0H, Lbtran, C30, LBGtran, dia5, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1370" upshifts 3187702 /Source="Nicolas_upshifts" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box 3187774..3187874 /Source="Nicolas_upshift_promotors" /id="U2796" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.711288711288711" /psig="0.104895104895105" /xcortree=14 /SigmaFactorBS="agggttgatatgatataaacgaaaatcaattagataaaggaa aaactgaacacttctgaaaaaagtgataagtttctttcactatatcctccaaaaagaa c" /listShort="yvzE" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3187834 /Source="Nicolas_upshifts" /id="U2796" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.711288711288711" /psig="0.104895104895105" /xcortree=14 /SigmaFactorBS="agggttgatatgatataaacgaaaatcaattagataaaggaa aaactgaacacttctgaaaaaagtgataagtttctttcactatatcctccaaaaagaa c" /listShort="yvzE" /GFF_Attribute="listLong" /label="upshifts" CDS 3187838..3188434 /gene="yvzE" /locus_tag="BSU_35699" /old_locus_tag="BSU35699" /EC_number="2.7.7.9" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase (UDP-glucose pyrophosphorylase) (UDPGP) (fragment)" /db_xref="PSEUDO:CAX52702.1" /translation="MISFFHYILQKEPKGLGHAVWFAPNFIGDEPFAFLLGDDIVQAD TPGLRQLTDEYERTLSSIIGVQQVPEDETHCYGIIAPLTSEGRRYQVKNFIEKPPKDT APSNLAILGRYVFTPEIFMYLEEQQVGAGGEIQLTDAIQKLNEIQRVFAYDFEGKRYD VGEKLGFITTTLEFAMQDKELRDQLVPFMEGLLNKEEI*" /label="yvzE CDS" gene 3187838..3188434 /gene="yvzE" /locus_tag="BSU_35699" /old_locus_tag="BSU35699" /pseudo /label="yvzE gene" downshifts 3188032 /Source="Nicolas_upshifts" /id="D1844" /incds=1 /nref=94 /ntot=183 /MaxReadThrough="4.62614" /MaxDrop="5.15039" /score="34.2325445" /energy="-14.3" /TU="U2792,U2795" /idTUdmin="U2796" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3188473..3190056) /gene="tagH" /locus_tag="BSU_35700" /old_locus_tag="BSU35700" /EC_number="3.6.3.40" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7565096, 12682299, 17012386, 18156271; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP-binding teichoic acid precursor transporter component" /protein_id="NP_391451.1" /db_xref="EnsemblGenomes-Gn:BSU35700" /db_xref="EnsemblGenomes-Tr:CAB15587" /db_xref="GOA:P42954" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015860" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030284" /db_xref="SubtiList:BG11191" /db_xref="UniProtKB/Swiss-Prot:P42954" /translation="MKLKVSFRNVSKQYHLYKKQSDKIKGLFFPAKDNGFFAVRNVSF DVYEGETIGFVGINGSGKSTMSNLLAKIIPPTSGEIEMNGQPSLIAIAAGLNNQLTGR DNVRLKCLMMGLTNKEIDDMYDSIVEFAEIGDFINQPVKNYSSGMKSRLGFAISVHID PDILIIDEALSVGDQTFYQKCVDRINEFKKQGKTIFFVSHSIGQIEKMCDRVAWMHYG ELRMFDETKTVVKEYKAFIDWFNKLSKKEKETYKKEQTEERKKEDPEAFARFRKKKKK PKSLANAIQIAILSILTVFMAGTMFFNAPLRTIASFGAIPQNEVKNHHGDAKGKSEER LTAINKQGFIANEKAAAYKDQGLKQKADVTLPFGTKVTVAAKGKQAAKIKFDGHSYYV KQSAVATNMKHAELHATAFTSYVSQNAASSYEYFLKFLGDSSTSIQSKLNGYTEGNKA DGRKTLNFDYEKISYVLENDKATELIFHNISPINPASLSLSDSDVLYDSSKKRFLVNT DDQVFAVDNEEHTLTLMLK*" /label="tagH CDS" gene complement(3188473..3190056) /gene="tagH" /locus_tag="BSU_35700" /old_locus_tag="BSU35700" /label="tagH gene" downshifts 3188516 /Source="Nicolas_upshifts" /id="D1845" /incds=0 /nref=2 /ntot=19 /MaxReadThrough="1.20059" /MaxDrop="5.25978" /score="34.2325445" /energy="-14.3" /TU="NA" /idTUdmin="U2792" /TUdmin=440 /isTUend="FALSE" /label="downshifts" CDS complement(3190076..3190903) /gene="tagG" /locus_tag="BSU_35710" /old_locus_tag="BSU35710" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7565096, 12682299, 15849754, 16850406, 17012386, 18156271, 27213893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="teichoic acid precursors permease" /protein_id="NP_391452.1" /db_xref="EnsemblGenomes-Gn:BSU35710" /db_xref="EnsemblGenomes-Tr:CAB15588" /db_xref="GOA:P42953" /db_xref="InterPro:IPR000412" /db_xref="InterPro:IPR013525" /db_xref="SubtiList:BG11205" /db_xref="UniProtKB/Swiss-Prot:P42953" /translation="MNDLLRILREQITSFPLILRLAAYETKSKYQMNYLGVLWQFLNP LIQMLAYWFVFGMGIRKGGPVTTGAGEVPFIIWMLAGLIPWFFISPTILDGSNSVFKR INMVAKMNFPISSLPSVAIASNLFSYMIMMVIYIIVLLVNGVFPSVHWLQYIYYFICM IAFMFSFSLFNSTISVLIRDYQFLLQAVTRLLFFLLPIFWDVNAKLGQSHPELVPVLK LNPLFYIIEGFRNSFLDGAWFFHDMKYTLYFWLFTFLLLLVGSILHMKFRDKFVDFL* " /label="tagG CDS" gene complement(3190076..3190903) /gene="tagG" /locus_tag="BSU_35710" /old_locus_tag="BSU35710" /label="tagG gene" S_feature complement(3190904..3190968) /Source="Nicolas_S_feature" /locus_tag="new_3675995_3676059_c" /HighExp="H2O2, LBGstat, dia15, Oxctl, LBGexp, G150, Paraq, G180, G135, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1371" promotor_-10 complement(3190964..3190983) /Source="Nicolas_upshift_promotors" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3190968) /Source="Nicolas_upshifts" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3190970..3191067) /Source="Nicolas_S_feature" /locus_tag="new_3676061_3676158_c" /HighExp="G180, G135, Cold, G150, LPh, S0, Oxctl, Paraq, HPh, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1372" promotor_-35 complement(3190999..3191002) /Source="Nicolas_upshift_promotors" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3191068..3193308) /gene="tagF" /locus_tag="BSU_35720" /old_locus_tag="BSU35720" /EC_number="2.7.8.12" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16689786, 17012386, 18723614, 19520862, 20400947" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16689786, 17012386, 18723614, 19520862, 20400947; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="CDP-glycerol:polyglycerol phosphate glycero-phosphotransferase (poly(glycerol phosphate) polymerase)" /protein_id="NP_391453.1" /db_xref="EnsemblGenomes-Gn:BSU35720" /db_xref="EnsemblGenomes-Tr:CAB15589" /db_xref="GOA:P13485" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10725" /db_xref="UniProtKB/Swiss-Prot:P13485" /translation="MSLVVDTNKRKQKGKSFYTEEQKKVMIENTVIKCILKSLKNNLG SLELLISIDSEHQFLEDYQLFLKLKERRSGTESEFPLQNTGSLEYKTEINAHVLPMPV EMGQTYDFYVEFRKKYEDAEQEPLLKRLSAEVNSIERAFHVDQTTELLILPYTTDKGN FSIKVKREAKIIRFDQIEISSEEISITGYAGYLSSENQYRIKNLNLILKKGGETPIEE KFPIKLERKTHGLENMRADGFVPELYDFEVKVPLKEIPFSNEKRYVYRLFMEYICNDD EGTDIQFNSTALVLGDRKNKLKGLVSIIKTNNAPVRYEVFKKKKKQTLGIRVNDYSLK TRMKYFIKGKKKRLVSKIKKITKMRNKLITKTYKSLFMMASRMPVKRKTVIFESFNGK QYSCNPRAIYEYMRENHPEYKMYWSVNKQYSAPFDEKGIPYINRLSLKWLFAMARAEY WVVNSRLPLWIPKPSHTTYLQTWHGTPLKRLAMDMEEVHMPGTNTKKYKRNFIKEASN WDYLISPNGYSTEIFTRAFQFNKTMIESGYPRNDFLHNDNNEETISLIKSRLNIPRDK KVILYAPTWRDDQFYAKGRYKFDLDLDLHQLRQELGNEYIVILRMHYLVAENFDLGPF EGFAYDFSAYEDIRELYMVSDLLITDYSSVFFDFANLKRPMLFFVPDIETYRDKLRGF YFDFEKEAPGPLVKTTEETIEAIKQISSPDYKLPVSFGPFYDKFCYLESGRSSEKVVN TVFKAE*" /label="tagF CDS" gene complement(3191068..3193308) /gene="tagF" /locus_tag="BSU_35720" /old_locus_tag="BSU35720" /label="tagF gene" CDS complement(3193308..3195329) /gene="tagE" /locus_tag="BSU_35730" /old_locus_tag="BSU35730" /EC_number="2.4.1.52" /function="16.8: Protect" /function="16.5: Explore" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2507871, 9457886, 12682299, 16141206, 16689786, 17012386, 21558268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2507871, 9457886, 12682299, 16141206, 16689786, 17012386, 21558268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose:polyglycerol phosphate alpha-glucosyltransferase" /protein_id="NP_391454.1" /db_xref="EnsemblGenomes-Gn:BSU35730" /db_xref="EnsemblGenomes-Tr:CAB15590" /db_xref="GOA:P13484" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR015397" /db_xref="SubtiList:BG10724" /db_xref="UniProtKB/Swiss-Prot:P13484" /translation="MSLHAVSESNIKQIPDMDYYFISGGLPSNYGGLTKSLLLRSKLF GEECNQNTFFLTFRFDLELSSKIDELYSNGKIDKKFTSVINLFDDFLSVRTNGKRSYE ERIGLDQIKKQVGMGKFAKTLLRLFGKKNNEMSVVYYGDGETIRYVDYWNDKNQLIKR EEYTKNGNLVLVTHYDVQLNKMYLQEYINDQNQVYLDKLYVWNNEEKDVQLSHIIWYS LEGEIKVKDESELRQYWIEYLQKQNDKPKLFLVDSRPQDKHVFKVKKSPSSYYGAIIH NKHYGSNKYQIKGRYKEVFSQMYNLDAVFFITEEQLEDFKLISGEQETFFFTPHTIDK PLDPAVLNVPSEKYKAVIISRLASMKNLIHAVKAFSLVVKEIPEAKLDIFGSGEDFEK IKKEIEDTKLQNNVFLKGYTDNPDSEFQKAWLTISTSHFEGFGLSNMEALSNGCPVVT YDYDYGARSLVTDGANGYVIEQYNIEKLGQAIISLMKDESTHQKFSEQAFKMAEKYSR PNYIENWAFALNQMIEVRIEREKFSKKVGKKDPSISSYTEDFDKTKIEIDIENFDHND IKKIRLVGLDRKNKAEIISTNLQNDQLFVIDLEKDVNIEKIAANKTQVIDFYIVFNAN GHIKTMRRLSSEETKLSGNSIDTNNGYRVEPYTTVKGNFSWRVTEIKES*" /label="tagE CDS" gene complement(3193308..3195329) /gene="tagE" /locus_tag="BSU_35730" /old_locus_tag="BSU35730" /label="tagE gene" promotor_-35 3194071..3194080 /Source="Nicolas_upshift_promotors" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3194093..3194108 /Source="Nicolas_upshift_promotors" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3194104 /Source="Nicolas_upshifts" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3195330..3195489) /Source="Nicolas_S_feature" /locus_tag="new_3680421_3680580_c" /HighExp="G180, G135, Cold, G150, Oxctl, LBGexp, Paraq, Lbexp, LPhT, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1373" CDS complement(3195490..3195879) /gene="tagD" /locus_tag="BSU_35740" /old_locus_tag="BSU35740" /EC_number="2.7.7.39" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11673441, 12637027, 12637499, 12682299, 16141206, 16689786, 17012386, 21558268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11673441, 12637027, 12637499, 12682299, 16141206, 16689786, 17012386, 21558268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycerol-3-phosphate cytidylyltransferase" /protein_id="NP_391455.1" /db_xref="EnsemblGenomes-Gn:BSU35740" /db_xref="EnsemblGenomes-Tr:CAB15591" /db_xref="GOA:P27623" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR006409" /db_xref="InterPro:IPR014729" /db_xref="PDB:1COZ" /db_xref="PDB:1N1D" /db_xref="SubtiList:BG10449" /db_xref="UniProtKB/Swiss-Prot:P27623" /translation="MKKVITYGTFDLLHWGHIKLLERAKQLGDYLVVAISTDEFNLQK QKKAYHSYEHRKLILETIRYVDEVIPEKNWEQKKQDIIDHNIDVFVMGDDWEGKFDFL KDQCEVVYLPRTEGISTTKIKEEIAGL*" /label="tagD CDS" gene complement(3195490..3195879) /gene="tagD" /locus_tag="BSU_35740" /old_locus_tag="BSU35740" /label="tagD gene" S_feature complement(3195880..3196014) /Source="Nicolas_S_feature" /locus_tag="new_3680971_3681105_c" /HighExp="BC, Cold, T3.0H, HiOs, MG-0.2, T1.30H, T3.30H, LPhT, MG 15, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1374" promotor_-10 complement(3195998..3196017) /Source="Nicolas_upshift_promotors" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3196014) /Source="Nicolas_upshifts" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3196028..3196035) /Source="Nicolas_upshift_promotors" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3196169..3196175 /Source="Nicolas_upshift_promotors" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3196186..3196278 /Source="Nicolas_S_feature" /locus_tag="new_3681277_3681369" /HighExp="B60, LoTm, Cold, T3.30H, T3.0H, Salt, T5.0H, T4.0H, Lbexp, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1375" upshifts 3196186 /Source="Nicolas_upshifts" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3196187..3196206 /Source="Nicolas_upshift_promotors" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3196279..3197049 /gene="tagA" /locus_tag="BSU_35750" /old_locus_tag="BSU35750" /EC_number="2.4.1.187" /function="16.5: Explore" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16689786, 16953575, 17012386, 18156271, 19376878" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16689786, 16953575, 17012386, 18156271, 19376878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmannosamine (ManNAc) C4 hydroxyl of a membrane-anchored N-acetylglucosaminyl diphospholipid (GlcNAc-pp-undecaprenyl, lipid I) glycosyltransferase" /protein_id="NP_391456.1" /db_xref="EnsemblGenomes-Gn:BSU35750" /db_xref="EnsemblGenomes-Tr:CAB15592" /db_xref="GOA:P27620" /db_xref="InterPro:IPR004629" /db_xref="InterPro:IPR034714" /db_xref="SubtiList:BG10450" /db_xref="UniProtKB/Swiss-Prot:P27620" /translation="MQTETIHNIPYVNSNLTSFIDYLEKHYIDQKIGAVISTVNPEIA FAAIKDRDYFDVLSSSNFILPDGIGVVMMSRLTNNRLQSRIAGYDVFKELLGVANKKK KRIFLYGAKKDVIKGVVSKISSEYPNIKIAGYSDGYVQDRTLVAKQIARANPDMVFVA LGYPHQEKFIHNYRHLFPKAVSIGLGGSFDVFSGNVKRAPSWMIRLNLEWFYRLILNP WRWKRMLSIPKYALTVLKEEKNKKTFYPKPEKDHTKQI*" /label="tagA CDS" gene 3196279..3197049 /gene="tagA" /locus_tag="BSU_35750" /old_locus_tag="BSU35750" /label="tagA gene" S_feature complement(3196406..3196754) /Source="Nicolas_S_feature" /locus_tag="new_3681497_3681845_c" /HighExp="S8, S6, S7, S5, S4, G135, S3, C30, G180, ferm" /AntisenseName="tagA" /AntisenseCor="-0.35014495927301897" /AntisenseRegPval="-8.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1376" promotor_-10 complement(3196758..3196769) /Source="Nicolas_upshift_promotors" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3196762) /Source="Nicolas_upshifts" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3196784..3196790) /Source="Nicolas_upshift_promotors" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3197074 /Source="Nicolas_upshifts" /id="D1846" /incds=0 /nref=2 /ntot=103 /MaxReadThrough="6.64821" /MaxDrop="3.225" /score="-6.01444425" /energy="-10.9" /TU="U2800" /idTUdmin="U2800" /TUdmin="-2310" /isTUend="FALSE" /label="downshifts" CDS 3197082..3198227 /gene="tagB" /locus_tag="BSU_35760" /old_locus_tag="BSU35760" /EC_number="2.7.8.44" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16150696, 16689786, 17012386, 17660278, 18156271, 18761696" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16150696, 16689786, 17012386, 17660278, 18156271, 18761696; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid primase, CDP-glycerol:N-acetyl-beta-d-mannosaminyl-1, 4-N-acetyl-d-glucosaminyldiphosphoundecaprenyl glycerophosphotransferase" /protein_id="NP_391457.1" /db_xref="EnsemblGenomes-Gn:BSU35760" /db_xref="EnsemblGenomes-Tr:CAB15593" /db_xref="GOA:P27621" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10451" /db_xref="UniProtKB/Swiss-Prot:P27621" /translation="MKIRSLLANCYLYFLSAIAFFLQWVKPESKVTLLISFEANAKAI LEEYEQGQYSYKLNILYTQQASAIAESFPNVDAYLLQEKNPIHLIKAVYLMFNSKVII TDNYFLLTSVLNKRKQTKCIQVWHANGSLKKFGLEDITNMQRTKTDIKRFQKVYSSYD YLTVGSEEMANIFKKSFGIKDNQLLKIGVPLTDPYYRENKKKISDTLNIQRKKIILYA PTFRDYNMQSIQLPFTEEQLIHQLKEEYVLFVKLHPAIQNNIDIKYSSDYIKDVSNYA LFDLLMAADILITDYSSVPFEFSILNKPILFYTYDLKLYQQKRGLVDNYLSIIPGRAC YDSESLINEIQTPFNYSKIKVFSDRWNKYSDGNSSQNLLNFIENLIS*" /label="tagB CDS" gene 3197082..3198227 /gene="tagB" /locus_tag="BSU_35760" /old_locus_tag="BSU35760" /label="tagB gene" downshifts 3198215 /Source="Nicolas_upshifts" /id="D1847" /incds=0 /nref=101 /ntot=235 /MaxReadThrough="3.54908" /MaxDrop="5.95551" /score="-3.22062454" /energy="-10" /TU="U2800" /idTUdmin="U2800" /TUdmin="-1169" /isTUend="FALSE" /label="downshifts" promotor_-35 3198269..3198276 /Source="Nicolas_upshift_promotors" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3198291..3198310 /Source="Nicolas_upshift_promotors" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3198301 /Source="Nicolas_upshifts" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="upshifts" CDS 3198347..3199675 /gene="tagC" /locus_tag="BSU_35770" /old_locus_tag="BSU35770" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7952180, 16269821; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative polyglycerol phosphate assembly and export protein (teichoic acid biosynthesis)" /protein_id="NP_391458.1" /db_xref="EnsemblGenomes-Gn:BSU35770" /db_xref="EnsemblGenomes-Tr:CAB15594" /db_xref="GOA:P27622" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG10453" /db_xref="UniProtKB/Swiss-Prot:P27622" /translation="MRKKELFDFTNITPKLFTELRVADKTVLQSFNFDEKNHQIYTTQ VASGLGKDNTQSYRITRLSLEGLQLDSMLLKHGGHGTNIGIENRNGTIYIWSLYDKPN ETDKSELVCFPYKAGATLDENSKELQRFSNMPFDHRVTPALDMKNRQLAIRQYDTKNN NNKQWVTIFNLDDAIANKNNPLYTINIPDELHYLQGFFLDDGYLYWYTGDTNSKSYPN LITVFDSDNKIVLQKEITVGKDLSTRYENNFREPEGICMYTNPETGAKSLMVGITSGK EGNRISRIYAYHSYENFMNHVPMLRSPLLKTVGHQDTPPERFQPFIQTFILEYNAQNK KWMVPTSGYLPSYTSNLVRNITINADGNLQVTLNERYISLLHQSIEGDFRLKQKDIRM GSWYFAGGEKSNVLEIGFMKGSTKIRPDDAAISNASRMSIFMIVADKIEV*" /label="tagC CDS" gene 3198347..3199675 /gene="tagC" /locus_tag="BSU_35770" /old_locus_tag="BSU35770" /label="tagC gene" downshifts 3199670 /Source="Nicolas_upshifts" /id="D1848" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="2.77356" /MaxDrop="4.002" /score="-7.52215775" /energy="-19.3" /TU="NA" /idTUdmin="U2802" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3199731) /Source="Nicolas_upshifts" /id="D1849" /incds=0 /nref=141 /ntot=248 /MaxReadThrough="0.94732" /MaxDrop="5.40128" /score="-0.11635468" /energy="-19.3" /TU="NA" /idTUdmin="U2803" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(3199735..3202377) /gene="lytD" /locus_tag="BSU_35780" /old_locus_tag="BSU35780" /EC_number="3.2.1.96" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9537764, 10206711, 17298895, 19542270, 22469514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9537764, 10206711, 17298895, 19542270, 22469514; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported N-acetylglucosaminidase (major autolysin) (CWBP90)" /protein_id="NP_391459.1" /db_xref="EnsemblGenomes-Gn:BSU35780" /db_xref="EnsemblGenomes-Tr:CAB15595" /db_xref="GOA:P39848" /db_xref="InterPro:IPR002901" /db_xref="InterPro:IPR003646" /db_xref="InterPro:IPR007730" /db_xref="InterPro:IPR036680" /db_xref="SubtiList:BG10455" /db_xref="UniProtKB/Swiss-Prot:P39848" /translation="MKKRLIAPMLLSAASLAFFAMSGSAQAAAYTDYSLYKVEPSNTF STESQASQAVAKLEKDTGWDASYQASGTTTTYQISASGIHSESEAKAILSGLAKQTSI TGTSSPVGSKQPYVTISSGAISGEKQANTILAKLKQETGVAGAVKAYGAAQPYMNVMT SDIADETKVKALIQSLAKQTGIKSSYQPITHTVSVTTIQSGTIVGDSRAAQIKNAFQK ESGLQASLKETVKGQAYYTFTTAAISGEANAKTLLQQLKQSTGITGSYKSINQKTTVE SYNVQSAYFKGLSTVKDAISQIKKNTGVSGSYQQVGKSTSYTVNMKGITKQQLQKIDT FFKKKKWHYTSSSVKKTTTSAAYQITTAKILGEQQANKAAAFFAQKKVKAAKTAAGST AENQYQLISEETSDQAKVTKGLNILKKNQLSASAKSVKKQIADTFKITTESLLDQTKV NQALTFFKSNHISVASQKTGQTAASSYQITTEAIISQEEIDRVLTFFKQNHIAVTTSK TGQTAYTQYKIVTTQLSSKTALNNGLTYLKSKSVTPSYTTKSNTLYKISVNEQFTGND TAAAASTKLKQLYGWTSSIVKIKNGPQIMKTNYNLSLRDMVQKQMTVSPQTDGAAYVS LTYINTATSTVTADVLNIRSTPEVSPTNVIGQFKKGDKVKVIGQINGWAKINLGWRNA SSDEVVQYVDPNNFSRDSKYYFQFLKLSQTAGLSVTEVNQKVLAGKGILTGRAKAFID AANQYSINELYLISHALLETGNGTSALANGLTYNGKTVYNMYGIGAYDSNPNYYGAKY AYEQGWFTPEAAIIGGAKFIGSSYIHNTAYNQDTLYKMRWSATATHQYATDIGWAYKQ VNRMYSLYSLLDGYTLYFDVPEYR*" /label="lytD CDS" gene complement(3199735..3202377) /gene="lytD" /locus_tag="BSU_35780" /old_locus_tag="BSU35780" /label="lytD gene" promotor_-10 complement(3200980..3200999) /Source="Nicolas_upshift_promotors" /id="U2803" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1231 /SigmaFactorBS="gatcaaacgaaagtcaatcagGCACTCACGTttttcaaatcg aATCATATATCAGTAGCAAGCcagaaaaccggtcagacagctgcgagcagctatcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3200982) /Source="Nicolas_upshifts" /id="U2803" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1231 /SigmaFactorBS="gatcaaacgaaagtcaatcagGCACTCACGTttttcaaatcg aATCATATATCAGTAGCAAGCcagaaaaccggtcagacagctgcgagcagctatcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3201012..3201021) /Source="Nicolas_upshift_promotors" /id="U2803" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1231 /SigmaFactorBS="gatcaaacgaaagtcaatcagGCACTCACGTttttcaaatcg aATCATATATCAGTAGCAAGCcagaaaaccggtcagacagctgcgagcagctatcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3202412..3202430) /Source="Nicolas_upshift_promotors" /id="U2804" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2808 /SigmaFactorBS="tttattagaaaatggaagtgattcacCTATAAATgaagcatg cgcgtGCCGATAAATAAACTAGTTttatatactcatagaataagaaagaggagaagga a" /listShort="lytD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3202417) /Source="Nicolas_upshifts" /id="U2804" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2808 /SigmaFactorBS="tttattagaaaatggaagtgattcacCTATAAATgaagcatg cgcgtGCCGATAAATAAACTAGTTttatatactcatagaataagaaagaggagaagga a" /listShort="lytD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3202444..3202451) /Source="Nicolas_upshift_promotors" /id="U2804" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2808 /SigmaFactorBS="tttattagaaaatggaagtgattcacCTATAAATgaagcatg cgcgtGCCGATAAATAAACTAGTTttatatactcatagaataagaaagaggagaagga a" /listShort="lytD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3202506..3203456) /gene="pmiA" /locus_tag="BSU_35790" /old_locus_tag="BSU35790" /EC_number="5.3.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7581999, 10704478, 19447949, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7581999, 10704478, 19447949, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="mannose-6-phosphate isomerase (active on aldose substrates with hydroxyl groups oriented in the same direction at the C-2 and C-3 positions as in mannose)" /protein_id="NP_391460.1" /db_xref="EnsemblGenomes-Gn:BSU35790" /db_xref="EnsemblGenomes-Tr:CAB15596" /db_xref="GOA:P39841" /db_xref="InterPro:IPR001250" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014628" /db_xref="InterPro:IPR014710" /db_xref="PDB:1QWR" /db_xref="SubtiList:BG10454" /db_xref="UniProtKB/Swiss-Prot:P39841" /translation="MTQSPIFLTPVFKEKIWGGTALRDRFGYSIPSESTGECWAISAH PKGPSTVANGPYKGKTLIELWEEHREVFGGVEGDRFPLLTKLLDVKEDTSIKVHPDDY YAGENEEGELGKTECWYIIDCKENAEIIYGHTARSKTELVTMINSGDWEGLLRRIKIK PGDFYYVPSGTLHALCKGALVLETQQNSDATYRVYDYDRLDSNGSPRELHFAKAVNAA TVPHVDGYIDESTESRKGITIKTFVQGEYFSVYKWDINGEAEMAQDESFLICSVIEGS GLLKYEDKTCPLKKGDHFILPAQMPDFTIKGTCTLIVSHI*" /label="pmiA CDS" gene complement(3202506..3203456) /gene="pmiA" /locus_tag="BSU_35790" /old_locus_tag="BSU35790" /label="pmiA gene" downshifts complement(3202518) /Source="Nicolas_upshifts" /id="D1850" /incds=0 /nref=29 /ntot=177 /MaxReadThrough="4.74566" /MaxDrop="3.72936" /score="9.64549533" /energy="-7.7" /TU="U2805" /idTUdmin="U2806" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3203481..3203499) /Source="Nicolas_upshift_promotors" /id="U2805" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=167 /SigmaFactorBS="cataggaaaaaggcagcttatacgggCGTTTGTaagaggggc gcaccGGGAAAATGATGATCAGTTatttacaggggaggggtacggatcatgacgcaat c" /listShort="yvyI, lytD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3203486) /Source="Nicolas_upshifts" /id="U2805" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=167 /SigmaFactorBS="cataggaaaaaggcagcttatacgggCGTTTGTaagaggggc gcaccGGGAAAATGATGATCAGTTatttacaggggaggggtacggatcatgacgcaat c" /listShort="yvyI, lytD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3203488..3203624) /Source="Nicolas_S_feature" /locus_tag="new_3688579_3688715_c" /HighExp="Lbtran, S0, M40t90, T1.0H, dia0, Mt0, Lbstat, M0t90, Lbexp, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.17043900000000001" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S1377" promotor_-35 complement(3203514..3203520) /Source="Nicolas_upshift_promotors" /id="U2805" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=167 /SigmaFactorBS="cataggaaaaaggcagcttatacgggCGTTTGTaagaggggc gcaccGGGAAAATGATGATCAGTTatttacaggggaggggtacggatcatgacgcaat c" /listShort="yvyI, lytD" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3203598..3203617) /Source="Nicolas_upshift_promotors" /id="U2806" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.664335664335664" /psig="0.994005994005994" /xcortree=1553 /SigmaFactorBS="tattaatttgtatcaaaaaaggagaattattcttatcgagga aaaggctgaaacaaagcttcttttcgaCGTGATATAATAGATAGGAAgcgttttcttt g" /listShort="S1377, yvyI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3203626) /Source="Nicolas_upshifts" /id="U2806" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.664335664335664" /psig="0.994005994005994" /xcortree=1553 /SigmaFactorBS="tattaatttgtatcaaaaaaggagaattattcttatcgagga aaaggctgaaacaaagcttcttttcgaCGTGATATAATAGATAGGAAgcgttttcttt g" /listShort="S1377, yvyI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3203654..3203660 /Source="Nicolas_upshift_promotors" /id="U2807" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=900 /SigmaFactorBS="cacgtcgaaaagaagctttgtttcagccttttcctcgataAG AATAAttctccttttttgATACAAATTAATaaaaaccgtcaatatgtttaagaaggag a" /listShort="gerBA, gerBB, gerBC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3203674..3203685 /Source="Nicolas_upshift_promotors" /id="U2807" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=900 /SigmaFactorBS="cacgtcgaaaagaagctttgtttcagccttttcctcgataAG AATAAttctccttttttgATACAAATTAATaaaaaccgtcaatatgtttaagaaggag a" /listShort="gerBA, gerBB, gerBC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3203674 /Source="Nicolas_upshifts" /id="U2807" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=900 /SigmaFactorBS="cacgtcgaaaagaagctttgtttcagccttttcctcgataAG AATAAttctccttttttgATACAAATTAATaaaaaccgtcaatatgtttaagaaggag a" /listShort="gerBA, gerBB, gerBC" /GFF_Attribute="listLong" /label="upshifts" CDS 3203721..3205172 /gene="gerBA" /locus_tag="BSU_35800" /old_locus_tag="BSU35800" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:3110007, 8012571, 10411756, 15774895, 22493018, 23749970, 25681191, 25790435" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3110007, 8012571, 10411756, 15774895, 22493018, 23749970, 25681191, 25790435; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="component of germinant receptor B" /protein_id="NP_391461.2" /db_xref="EnsemblGenomes-Gn:BSU35800" /db_xref="EnsemblGenomes-Tr:CAB15597" /db_xref="GOA:P39569" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG10640" /db_xref="UniProtKB/Swiss-Prot:P39569" /translation="MQIDSDLQNNLDTLKKTLGQNDDMMFYTFAFGDSRQKACLLYID GLTENKMLAQYVISPLQKEALAHKECSIEDLSAFFFGFHHSVVSTMKEIEQLVFSGQA ILLADGYRGGLAFDTKSVATRSLDEPSSEVVERGPKIGFIEKLRTNTALLRERTSDPN LVIKEMTLGKRTKKKIAVAYIQDIAPDYVVKEVFKRLKSVNIDNLPESGTLEQLIEDE PFSIFPTILSTERPDRVESSLLEGRVSILVDGTPFALIVPATVDEFIHSPDDYSQRWI PMSLVRLLRYSSILITIYLPGLYISLVSFHTGLLPTRMAISIAGSRLNVPFPPFVEAF IMIFTIELIREAGLRLPKPIGQTIGLIGGVVIGQAAVQAQIVSALMVIVVSVTALASF TVPSYAYNFPLRIIRIGVMISATALGMYGVIMVYLFVIGHLMRLKSFGQDYIIPIMAQ PGQDLKDTVIRIPTMFLKRRPTRNDPEDNIRQR*" /label="gerBA CDS" gene 3203721..3205172 /gene="gerBA" /locus_tag="BSU_35800" /old_locus_tag="BSU35800" /label="gerBA gene" CDS 3205178..3206284 /gene="gerBB" /locus_tag="BSU_35810" /old_locus_tag="BSU35810" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:15774895, 15849754, 16352818, 16850406, 22493018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15774895, 15849754, 16352818, 16850406, 22493018; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="component of germinant receptor B" /protein_id="NP_391462.2" /db_xref="EnsemblGenomes-Gn:BSU35810" /db_xref="EnsemblGenomes-Tr:CAB15598" /db_xref="GOA:P39570" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG10641" /db_xref="UniProtKB/Swiss-Prot:P39570" /translation="MRKSEHKLTFMQTLIMISSTLIGAGVLTLPRSAAETGSPSGWLM ILLQGVIFIIIVLLFLPFLQKNSGKTLFKLNSIVAGKFIGFLLNLYICLYFIGIVCFQ ARILGEVVGFFLLKNTPMAVVVFIFLAVAIYHVGGGVYSIAKVYAYIFPITLIIFMML LMFSFRLFQLDFIRPVFEGGYQSFFSLFPKTLLYFSGFEIIFYLVPFMRDPKQVKKAV ALGIATSTLFYSITLLIVIGCMTVAEAKTVTWPTISLIHALEVPGIFIERFDLFLQLT WTAQQFACMLGSFKGAHIGLTEIFHLKNKNNAWLLTAMLAATFFITMYPKDLNDVFYY GTLLGYAFLIVITIPFFVWFLSWIQKKIGRGQLQ*" /label="gerBB CDS" gene 3205178..3206284 /gene="gerBB" /locus_tag="BSU_35810" /old_locus_tag="BSU35810" /label="gerBB gene" CDS 3206281..3207405 /gene="gerBC" /locus_tag="BSU_35820" /old_locus_tag="BSU35820" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:15774895, 15849754, 16352818, 16850406, 20654628, 21685283, 22493018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15774895, 15849754, 16352818, 16850406, 20654628, 21685283, 22493018; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein component of the germination receptor B" /protein_id="NP_391463.1" /db_xref="EnsemblGenomes-Gn:BSU35820" /db_xref="EnsemblGenomes-Tr:CAB15599" /db_xref="GOA:P39571" /db_xref="InterPro:IPR008844" /db_xref="PDB:3N54" /db_xref="SubtiList:BG10642" /db_xref="UniProtKB/Swiss-Prot:P39571" /translation="MKTASKFSVMFFMLLALCGCWDVKDIEQLSFARGLAIDETNDHQ YKLTYQNLLPQSEDSQASGKPEFVNVTSHGKTILEAVSDVSIKDPPVYSDHLKVILLG EKLMRNQNVDQVLNHFIRDDELRRSSYLMAARGNAADVFTKGNPNQQQPMPSEKLIDL TTHSGYNGKIMIPLRIGRASVYSQNGYSYLIQAVKNEKGKAKYDGAGIIKRGSNKLVG FLSADETQTLSWVMGTIQGGVMPTTDKGHPITFEIKKSKTKIKPVIENGKPVFHISVK TKGILTEDQNPNENSFSKSYLHRLENIFEKKLERDVKQVMDKLQHEYKTDPVFLSDHI RIQHPDYWNKVKGHWDEIFSETDFKYDISFKIINFGTVGK*" /label="gerBC CDS" gene 3206281..3207405 /gene="gerBC" /locus_tag="BSU_35820" /old_locus_tag="BSU35820" /label="gerBC gene" S_feature complement(3206508..3207402) /Source="Nicolas_S_feature" /locus_tag="new_3691599_3692493_c" /HighExp="Etha, Sw, Salt, Heat, S8, B36, Gly, S7, LPhT, S6" /AntisenseName="gerBC" /AntisenseCor="0.12062795031199899" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1378" downshifts 3207395 /Source="Nicolas_upshifts" /id="D1851" /incds=0 /nref=18 /ntot=72 /MaxReadThrough="0.37711" /MaxDrop="4.85405" /score="35.6875936" /energy="-14.9" /TU="NA" /idTUdmin="U2807" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3207442..3208815) /gene="ywtG" /locus_tag="BSU_35830" /old_locus_tag="BSU35830" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative carbohydrate/proton transporter" /protein_id="NP_391464.2" /db_xref="EnsemblGenomes-Gn:BSU35830" /db_xref="EnsemblGenomes-Tr:CAB15600" /db_xref="GOA:C0SPB2" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12538" /db_xref="UniProtKB/Swiss-Prot:C0SPB2" /translation="MKKQSNIWLYFFGALGGALYGYDTGVISGAILFMKKELGLNAFT EGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLF RIILGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFADAEA WRWMLGLAAVPSLLLLIGILFMPESPRWLFTNGEESKAKKILEKLRGTKDIDQEIHDI KEAEKQDEGGLKELFDPWVRPALIAGLGLAFLQQFIGTNTIIYYAPKTFTNVGFGNSA SILGTVGIGTVNVLMTLVAIKIIDKIGRKPLLLFGNAGMVISLIVLALVNLFFDNTPA ASWTTVICLGVFIVVFAVSWGPVVWVMLPELFPLHVRGIGTGVSTLMLHVGTLIVSLT YPILMEAIGISYLFLIYAAIGIMAFLFVRFKVTETKGRSLEEIEQDLRDKNGQGGAAG KQQTVGT*" /label="ywtG CDS" gene complement(3207442..3208815) /gene="ywtG" /locus_tag="BSU_35830" /old_locus_tag="BSU35830" /label="ywtG gene" downshifts complement(3207447) /Source="Nicolas_upshifts" /id="D1852" /incds=0 /nref=13 /ntot=90 /MaxReadThrough="6.08746" /MaxDrop="3.99424" /score="22.7548183" /energy="-16.7" /TU="U2808" /idTUdmin="U2808" /TUdmin="-900" /isTUend="FALSE" /label="downshifts" S_feature complement(3208816..3208879) /Source="Nicolas_S_feature" /locus_tag="new_3693907_3693970_c" /HighExp="Etha, Salt, Gly, Heat, Sw, LPhT, HiTm, Diami, B60, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1379" promotor_-10 complement(3208867..3208885) /Source="Nicolas_upshift_promotors" /id="U2808" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=188 /SigmaFactorBS="atgattggaaaacttatgatcagaaaaataaaaaGGTTTAAt ggccggaaaaagaGGCTAAAAGATTTCTAAAAaaatcccacagacaatgtcattgcag c" /listShort="S1379, ywtG, S1378" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3208880) /Source="Nicolas_upshifts" /id="U2808" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=188 /SigmaFactorBS="atgattggaaaacttatgatcagaaaaataaaaaGGTTTAAt ggccggaaaaagaGGCTAAAAGATTTCTAAAAaaatcccacagacaatgtcattgcag c" /listShort="S1379, ywtG, S1378" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3208900..3208906) /Source="Nicolas_upshift_promotors" /id="U2808" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=188 /SigmaFactorBS="atgattggaaaacttatgatcagaaaaataaaaaGGTTTAAt ggccggaaaaagaGGCTAAAAGATTTCTAAAAaaatcccacagacaatgtcattgcag c" /listShort="S1379, ywtG, S1378" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3208966..3208975 /Source="Nicolas_upshift_promotors" /id="U2809" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1659 /SigmaFactorBS="ttttccaatcatttacttgtatttttttcaatgtcgcCGAAA CATTTtacctgctgcgGCGTCCAATATAAGGTgattcagtacattatcgttatcaatt t" /listShort="S1380, ywtF, S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3208987..3209002 /Source="Nicolas_upshift_promotors" /id="U2809" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1659 /SigmaFactorBS="ttttccaatcatttacttgtatttttttcaatgtcgcCGAAA CATTTtacctgctgcgGCGTCCAATATAAGGTgattcagtacattatcgttatcaatt t" /listShort="S1380, ywtF, S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3208989..3209109 /Source="Nicolas_S_feature" /locus_tag="new_3694080_3694200" /HighExp="T-0.40H, LBGstat, T-1.10H, T0.30H, Heat, T-1.40H, T1.30H, T1.0H, T0.0H, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1380" upshifts 3208989 /Source="Nicolas_upshifts" /id="U2809" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1659 /SigmaFactorBS="ttttccaatcatttacttgtatttttttcaatgtcgcCGAAA CATTTtacctgctgcgGCGTCCAATATAAGGTgattcagtacattatcgttatcaatt t" /listShort="S1380, ywtF, S1381, ywtE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3209084..3209091 /Source="Nicolas_upshift_promotors" /id="U2810" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58041958041958" /psig="0.997002997002997" /xcortree=2249 /SigmaFactorBS="tataggaatatttatcgaaaaatgtctttcgagTAGTTGCCc catggcaaatagAATGGTACGCTTCAAATATTaaagaaacgtgaggtattgatatatg g" /listShort="ywtF, S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3209105..3209124 /Source="Nicolas_upshift_promotors" /id="U2810" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58041958041958" /psig="0.997002997002997" /xcortree=2249 /SigmaFactorBS="tataggaatatttatcgaaaaatgtctttcgagTAGTTGCCc catggcaaatagAATGGTACGCTTCAAATATTaaagaaacgtgaggtattgatatatg g" /listShort="ywtF, S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3209111 /Source="Nicolas_upshifts" /id="U2810" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58041958041958" /psig="0.997002997002997" /xcortree=2249 /SigmaFactorBS="tataggaatatttatcgaaaaatgtctttcgagTAGTTGCCc catggcaaatagAATGGTACGCTTCAAATATTaaagaaacgtgaggtattgatatatg g" /listShort="ywtF, S1381, ywtE" /GFF_Attribute="listLong" /label="upshifts" CDS 3209148..3210116 /gene="tagT" /locus_tag="BSU_35840" /old_locus_tag="BSU35840" /function="12: Regulatory functions" /experiment="publication(s) with functional evidences, PMID:19099556, 22432711, 29107701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19099556, 22432711, 29107701; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid-peptidoglycan tethering enzyme (LCP component) with transcription regulator domain of capsule synthesis" /protein_id="NP_391465.2" /db_xref="EnsemblGenomes-Gn:BSU35840" /db_xref="EnsemblGenomes-Tr:CAB15601" /db_xref="GOA:Q7WY78" /db_xref="InterPro:IPR004474" /db_xref="PDB:3MEJ" /db_xref="PDB:4DE9" /db_xref="SubtiList:BG12537" /db_xref="UniProtKB/Swiss-Prot:Q7WY78" /translation="MEERSQRRKKKRKLKKWVKVVAGLMAFLVIAAGSVGAYAFVKLN NASKEAHVSLARGEQSVKRIKEFDPGKDSFSVLLLGIDAREKNGETVDQARSDANVLV TFNRKEKTAKMLSIPRDAYVNIPGHGYDKFTHAHAYGGVDLTVKTVEEMLDIPVDYVV ESNFTAFEDVVNELNGVKVTVKSDKVIQQIKKDTKGKVVLQKGTHTLDGEEALAYVRT RKADSDLLRGQRQMEVLSAIIDKSKSLSSIPAYDDIVDTMGQNLKMNLSLKDAIGLFP FITSLKSVESIQLTGYDYEPAGVYYFKLNQQKLQEVKKELQNDLGV*" /label="tagT CDS" gene 3209148..3210116 /gene="tagT" /locus_tag="BSU_35840" /old_locus_tag="BSU35840" /label="tagT gene" downshifts 3210101 /Source="Nicolas_upshifts" /id="D1853" /incds=0 /nref=27 /ntot=139 /MaxReadThrough="6.07699" /MaxDrop="4.78541" /score="17.3040761" /energy="-17.8" /TU="U2809,U2810" /idTUdmin="U2809" /TUdmin="-1012" /isTUend="FALSE" /label="downshifts" promotor_-35 3210160..3210167 /Source="Nicolas_upshift_promotors" /id="U2811" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.982017982017982" /xcortree=1778 /SigmaFactorBS="cgattacgccatcccgttttacatatttcctTGTTGAAAatt atcaaagtaacGTTTAGCCTTAATTTATATGgattatgtttcacaggcaagctgaaca t" /listShort="S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3210182..3210201 /Source="Nicolas_upshift_promotors" /id="U2811" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.982017982017982" /xcortree=1778 /SigmaFactorBS="cgattacgccatcccgttttacatatttcctTGTTGAAAatt atcaaagtaacGTTTAGCCTTAATTTATATGgattatgtttcacaggcaagctgaaca t" /listShort="S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3210189..3210271 /Source="Nicolas_S_feature" /locus_tag="new_3695280_3695362" /HighExp="Etha, dia5, Lbtran, dia15, LBGexp, LBGtran, G150, Mt0, G180, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigWXY" /TUshortPSig="0.982, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1381" upshifts 3210189 /Source="Nicolas_upshifts" /id="U2811" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.982017982017982" /xcortree=1778 /SigmaFactorBS="cgattacgccatcccgttttacatatttcctTGTTGAAAatt atcaaagtaacGTTTAGCCTTAATTTATATGgattatgtttcacaggcaagctgaaca t" /listShort="S1381, ywtE" /GFF_Attribute="listLong" /label="upshifts" CDS 3210272..3211132 /gene="ribZB" /locus_tag="BSU_35850" /old_locus_tag="BSU35850" /EC_number="3.1.3.-" /function="4.9: Riboflavin, FMN, and FAD" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 26316208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-amino-6-ribitylamino-2,4(1H, 3H)-pyrimidinedione 5'-phosphate phosphatase (promiscuous activity)" /protein_id="NP_391466.1" /db_xref="EnsemblGenomes-Gn:BSU35850" /db_xref="EnsemblGenomes-Tr:CAB15602" /db_xref="GOA:P96741" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG12536" /db_xref="UniProtKB/Swiss-Prot:P96741" /translation="MKCIAIDLDGTLLNKESVISAENREAIKRAVDAGILVTICTGRA TFDVKALLDDLDIPIIAANGGTIHDTGYRLISRTLMDQEAGKAIADYLLSKNIYFEVY TDDHLLSPFDGEAKLHAELDILKSANPNEQTDDLWQGAMTQFKQFGIKPIPHIESVFD GGENIYKLLCFSFDMDKLKQAKEELKHHKKLAQTSSGKHIIEILPASSGKGRALTKLA DIYGIETQDIYAIGDSPNDLSMFEVAGHRIAMENAIDELKEKSTFVTKSNDENGVAYF IDQLLSGQYA*" /label="ribZB CDS" gene 3210272..3211132 /gene="ribZB" /locus_tag="BSU_35850" /old_locus_tag="BSU35850" /label="ribZB gene" downshifts 3211113 /Source="Nicolas_upshifts" /id="D1854" /incds=0 /nref=163 /ntot=235 /MaxReadThrough="3.35965" /MaxDrop="5.65658" /score="24.125299" /energy="-9.8" /TU="NA" /idTUdmin="U2809" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3211166..3212407) /gene="pgdS" /locus_tag="BSU_35860" /old_locus_tag="BSU35860" /EC_number="3.4.19.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12073126, 12644511, 16689787, 16952838, 26158264, 28664519" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12073126, 12644511, 16689787, 16952838, 26158264, 28664519; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="gamma-DD-glutamyl hydrolase (PGA depolymerase)" /protein_id="NP_391467.1" /db_xref="EnsemblGenomes-Gn:BSU35860" /db_xref="EnsemblGenomes-Tr:CAB15603" /db_xref="GOA:P96740" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG12535" /db_xref="UniProtKB/Swiss-Prot:P96740" /translation="MNTLANWKKFLLVAVIICFLVPIMTKAEIAEADTSSELIVSEAK NLLGYQYKYGGETPKEGFDPSGLIQYVFSKADIHLPRSVNDQYKIGTAVKPENLKPGD ILFFKKEGSTGTVPTHDALYIGDGQMVHSTQSKGVIITNYKKSSYWSGTYIGARRIAA DPATADVPVVQEAEKYIGVPYVFGGSTPSEGFDCSGLVQYVFQQALGIYLPRSAEQQW AVGEKVAPQNIKPGDVVYFSNTYKTGISHAGIYAGAGRFIQASRSEKVTISYLSEDYW KSKMTGIRRFDNLTIPKENPIVSEATLYVGEVPYKQGGVTPETGFDTAGFVQYVYQKA AGISLPRYATSQYNAGTKIEKADLKPGDIVFFQSTSLNPSIYIGNGQVVHVTLSNGVT ITNMNTSTYWKDKYAGSIRVQ*" /label="pgdS CDS" gene complement(3211166..3212407) /gene="pgdS" /locus_tag="BSU_35860" /old_locus_tag="BSU35860" /label="pgdS gene" downshifts complement(3211185) /Source="Nicolas_upshifts" /id="D1855" /incds=0 /nref=228 /ntot=317 /MaxReadThrough="2.27329" /MaxDrop="7.15996" /score="10.2499259" /energy="-9.8" /TU="NA" /idTUdmin="U2812" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3212429..3212447) /Source="Nicolas_upshift_promotors" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3212451) /Source="Nicolas_upshifts" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3212460..3212467) /Source="Nicolas_upshift_promotors" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3212548..3212715) /gene="edmS" /locus_tag="BSU_35870" /old_locus_tag="BSU35870" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16267300, 16689787, 20812257, 21357437, 23583563, 25843804" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16267300, 16689787, 20812257, 21357437, 23583563, 25843804; Product type f : factor" /codon_start=1 /transl_table=11 /product="factor required extrachromosomal elements maintenance" /protein_id="NP_391468.1" /db_xref="EnsemblGenomes-Gn:BSU35870" /db_xref="EnsemblGenomes-Tr:CAB15604" /db_xref="SubtiList:BG12534" /db_xref="UniProtKB/Swiss-Prot:P96739" /translation="MKFVKAIWPFVAVAIVFMFMSAFKFNDQLTDQEKQKIDMEMNKI QQQEEPVNANK*" /label="edmS CDS" gene complement(3212548..3212715) /gene="edmS" /locus_tag="BSU_35870" /old_locus_tag="BSU35870" /label="edmS gene" downshifts complement(3212575) /Source="Nicolas_upshifts" /id="D1856" /incds=0 /nref=1 /ntot=47 /MaxReadThrough="0.6752" /MaxDrop="2.78178" /score="24.9141523" /energy="-14.7" /TU="NA" /idTUdmin="U2812" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" CDS complement(3212730..3213872) /gene="capA" /locus_tag="BSU_35880" /old_locus_tag="BSU35880" /EC_number="6.3.2.-" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11606194, 11751809, 12644511, 16689787, 19745567, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11606194, 11751809, 12644511, 16689787, 19745567, 27818647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate synthetase (acid resistance)" /protein_id="NP_391469.1" /db_xref="EnsemblGenomes-Gn:BSU35880" /db_xref="EnsemblGenomes-Tr:CAB15605" /db_xref="InterPro:IPR019079" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12533" /db_xref="UniProtKB/Swiss-Prot:P96738" /translation="MKKELSFHEKLLKLTKQQKKKTNKHVFIAIPIVFVLMFAFMWAG KAETPKVKTYSDDVLSASFVGDIMMGRYVEKVTEQKGADSIFQYVEPIFRASDYVAGN FENPVTYQKNYKQADKEIHLQTNKESVKVLKDMNFTVLNSANNHAMDYGVQGMKDTLG EFAKQNLDIVGAGYSLSDAKKKISYQKVNGVTIATLGFTDVSGKGFAAKKNTPGVLPA DPEIFIPMISEAKKHADIVVVQSHWGQEYDNDPNDRQRQLARAMSDAGADIIVGHHPH VLEPIEVYNGTVIFYSLGNFVFDQGWTRTRDSALVQYHLKKNGTGRFEVTPIDIHEAT PAPVKKDSLKQKTIIRELTKDSNFAWKVEDGKLTFDIDHSDKLKSK*" /label="capA CDS" gene complement(3212730..3213872) /gene="capA" /locus_tag="BSU_35880" /old_locus_tag="BSU35880" /label="capA gene" CDS complement(3213891..3214340) /gene="capC" /locus_tag="BSU_35890" /old_locus_tag="BSU35890" /EC_number="6.3.2.-" /function="16.13: Shape" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11606194, 11751809, 15849754, 16689787, 16850406, 19734658" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11606194, 11751809, 15849754, 16689787, 16850406, 19734658; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate amide ligase/translocase subunit" /protein_id="NP_391470.1" /db_xref="EnsemblGenomes-Gn:BSU35890" /db_xref="EnsemblGenomes-Tr:CAB15606" /db_xref="GOA:P96737" /db_xref="InterPro:IPR008338" /db_xref="SubtiList:BG12532" /db_xref="UniProtKB/Swiss-Prot:P96737" /translation="MFGSDLYIALILGVLLSLIFAEKTGIVPAGLVVPGYLGLVFNQP VFILLVLLVSLLTYVIVKYGLSKFMILYGRRKFAAMLITGIVLKIAFDFLYPIVPFEI AEFRGIGIIVPGLIANTIQKQGLTITFGSTLLLSGATFAIMFVYYLI*" /label="capC CDS" gene complement(3213891..3214340) /gene="capC" /locus_tag="BSU_35890" /old_locus_tag="BSU35890" /label="capC gene" promotor_-35 3214034..3214040 /Source="Nicolas_upshift_promotors" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="promotor_-35" upshifts 3214048 /Source="Nicolas_upshifts" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="upshifts" promotor_-10 3214054..3214072 /Source="Nicolas_upshift_promotors" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="promotor_-10" S_feature 3214061..3216270 /Source="Nicolas_S_feature" /locus_tag="new_3699152_3701361" /HighExp="Sw, Salt, dia5, BC, B60, Diami, Lbstat, H2O2, dia15, Gly" /AntisenseName="pgsB" /AntisenseCor="7.6745622610153399E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="0.40410200000000002" /TUshortSig="SigB" /TUshortPSig="0.853" /TUlongSig="NA" /TUlongPSig="NA" /label="S1382" CDS complement(3214355..3215536) /gene="capB" /locus_tag="BSU_35900" /old_locus_tag="BSU35900" /EC_number="6.3.2.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11606194, 11751809, 12644511, 16689787, 19420703, 19734658, 27446033; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate synthetase (ATP-dependentamide ligase)" /protein_id="NP_391471.2" /db_xref="EnsemblGenomes-Gn:BSU35900" /db_xref="EnsemblGenomes-Tr:CAB15607" /db_xref="GOA:P96736" /db_xref="InterPro:IPR008337" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="SubtiList:BG12531" /db_xref="UniProtKB/Swiss-Prot:P96736" /translation="MWLLIIACAVILVIGILEKRRHQKNIDALPVRVNINGIRGKSTV TRLTTGILIEAGYKTVGKTTGTDARMIYWDTPEEKPIKRKPQGPNIGEQKEVMRETVE RGANAIVSECMAVNPDYQIIFQEELLQANIGVIVNVLEDHMDVMGPTLDEIAEAFTAT IPYNGHLVITDSEYTEFFKQKAKERNTKVIIADNSKITDEYLRKFEYMVFPDNASLAL GVAQALGIDEETAFKGMLNAPPDPGAMRILPLISPSEPGHFVNGFAANDASSTLNIWK RVKEIGYPTDDPIIIMNCRADRVDRTQQFANDVLPYIEASELILIGETTEPIVKAYEE GKIPADKLHDLEYKSTDEIMELLKKRMHNRVIYGVGNIHGAAEPLIEKIHEYKVKQLV S*" /label="capB CDS" gene complement(3214355..3215536) /gene="capB" /locus_tag="BSU_35900" /old_locus_tag="BSU35900" /label="capB gene" promotor_-35 3216250..3216257 /Source="Nicolas_upshift_promotors" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3216272 /Source="Nicolas_upshifts" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3216273..3216292 /Source="Nicolas_upshift_promotors" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3216293) /Source="Nicolas_upshifts" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3216298..3216312) /Source="Nicolas_upshift_promotors" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3216320..3216324) /Source="Nicolas_upshift_promotors" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3216320..3217300 /gene="rbsR" /locus_tag="BSU_35910" /old_locus_tag="BSU35910" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11750820, 16519689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11750820, 16519689; Product type r: regulator" /codon_start=1 /transl_table=11 /product="ribose operon repressor (LacI family, D-ribose)" /protein_id="NP_391472.1" /db_xref="EnsemblGenomes-Gn:BSU35910" /db_xref="EnsemblGenomes-Tr:CAB15608" /db_xref="GOA:P36944" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10876" /db_xref="UniProtKB/Swiss-Prot:P36944" /translation="MATIKDVAGAAGVSVATVSRNLNDNGYVHEETRTRVIAAMAKLN YYPNEVARSLYKRESRLIGLLLPDITNPFFPQLARGAEDELNREGYRLIFGNSDEELK KELEYLQTFKQNHVAGIIAATNYPDLEEYSGMNYPVVFLDRTLEGAPSVSSDGYTGVK LAAQAIIHGKSQRITLLRGPAHLPTAQDRFNGALEILKQAEVDFQVIETASFSIKDAQ SMAKELFASYPATDGVIASNDIQAAAVLHEALRRGKNVPEDIQIIGYDDIPQSGLLFP PLSTIKQPAYDMGKEAAKLLLGIIKKQPLAETAIQMPVTYIGRKTTRKED*" /label="rbsR CDS" gene 3216320..3217300 /gene="rbsR" /locus_tag="BSU_35910" /old_locus_tag="BSU35910" /label="rbsR gene" promotor_-35 3217149..3217156 /Source="Nicolas_upshift_promotors" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3217170..3217189 /Source="Nicolas_upshift_promotors" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3217185 /Source="Nicolas_upshifts" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="upshifts" CDS 3217302..3218183 /gene="rbsK" /locus_tag="BSU_35920" /old_locus_tag="BSU35920" /EC_number="2.7.1.15" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7921236, 16978644; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribokinase" /protein_id="NP_391473.1" /db_xref="EnsemblGenomes-Gn:BSU35920" /db_xref="EnsemblGenomes-Tr:CAB15609" /db_xref="GOA:P36945" /db_xref="InterPro:IPR002139" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR011877" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG10877" /db_xref="UniProtKB/Swiss-Prot:P36945" /translation="MRNICVIGSCSMDLVVTSDKRPKAGETVLGTSFQTVPGGKGANQ AVAAARLGAQVFMVGKVGDDHYGTAILNNLKANGVRTDYMEPVTHTESGTAHIVLAEG DNSIVVVKGANDDITPAYALNALEQIEKVDMVLIQQEIPEETVDEVCKYCHSHDIPII LNPAPARPLKQETIDHATYLTPNEHEASILFPELTISEALALYPAKLFITEGKQGVRY SAGSKEVLIPSFPVEPVDTTGAGDTFNAAFAVALAEGKDIEAALRFANRAASLSVCSF GAQGGMPTRNEVEELLS*" /label="rbsK CDS" gene 3217302..3218183 /gene="rbsK" /locus_tag="BSU_35920" /old_locus_tag="BSU35920" /label="rbsK gene" CDS 3218180..3218575 /gene="rbsD" /locus_tag="BSU_35930" /old_locus_tag="BSU35930" /EC_number="5.4.99.62" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7921236, 12738765, 21276853; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-ribose pyranase" /protein_id="NP_391474.1" /db_xref="EnsemblGenomes-Gn:BSU35930" /db_xref="EnsemblGenomes-Tr:CAB15610" /db_xref="GOA:P36946" /db_xref="InterPro:IPR007721" /db_xref="InterPro:IPR023064" /db_xref="InterPro:IPR023750" /db_xref="PDB:1OGC" /db_xref="PDB:1OGD" /db_xref="PDB:1OGE" /db_xref="PDB:1OGF" /db_xref="SubtiList:BG10878" /db_xref="UniProtKB/Swiss-Prot:P36946" /translation="MKKHGILNSHLAKILADLGHTDKIVIADAGLPVPDGVLKIDLSL KPGLPAFQDTAAVLAEEMAVEKVIAAAEIKASNQENAKFLENLFSEQEIEYLSHEEFK LLTKDAKAVIRTGEFTPYANCILQAGVLF*" /label="rbsD CDS" gene 3218180..3218575 /gene="rbsD" /locus_tag="BSU_35930" /old_locus_tag="BSU35930" /label="rbsD gene" CDS 3218591..3220072 /gene="rbsA" /locus_tag="BSU_35940" /old_locus_tag="BSU35940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (ATP-binding protein)" /protein_id="NP_391475.1" /db_xref="EnsemblGenomes-Gn:BSU35940" /db_xref="EnsemblGenomes-Tr:CAB15611" /db_xref="GOA:P36947" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015861" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10879" /db_xref="UniProtKB/Swiss-Prot:P36947" /translation="MQIEMKDIHKTFGKNQVLSGVSFQLMPGEVHALMGENGAGKSTL MNILTGLHKADKGQISINGNETYFSNPKEAEQHGIAFIHQELNIWPEMTVLENLFIGK EISSKLGVLQTRKMKALAKEQFDKLSVSLSLDQEAGECSVGQQQMIEIAKALMTNAEV IIMDEPTAALTEREISKLFEVITALKKNGVSIVYISHRMEEIFAICDRITIMRDGKTV DTTNISETDFDEVVKKMVGRELTERYPKRTPSLGDKVFEVKNASVKGSFEDVSFYVRS GEIVGVSGLMGAGRTEMMRALFGVDRLDTGEIWIAGKKTAIKNPQEAVKKGLGFITEN RKDEGLLLDTSIRENIALPNLSSFSPKGLIDHKREAEFVDLLIKRLTIKTASPETHAR HLSGGNQQKVVIAKWIGIGPKVLILDEPTRGVDVGAKREIYTLMNELTERGVAIIMVS SELPEILGMSDRIIVVHEGRISGEIHAREATQERIMTLATGGR*" /label="rbsA CDS" gene 3218591..3220072 /gene="rbsA" /locus_tag="BSU_35940" /old_locus_tag="BSU35940" /label="rbsA gene" CDS 3220074..3221042 /gene="rbsC" /locus_tag="BSU_35950" /old_locus_tag="BSU35950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (permease)" /protein_id="NP_391476.1" /db_xref="EnsemblGenomes-Gn:BSU35950" /db_xref="EnsemblGenomes-Tr:CAB15612" /db_xref="GOA:P36948" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10880" /db_xref="UniProtKB/Swiss-Prot:P36948" /translation="MKTEQLQTEQKRIHFDGVMQKLGPFLGLFILVIIVSILNPSFLE PLNILNLLRQVAINGLIAFGMTFVILTGGIDLSVGAILALSSALVAGMIVSGVDPVLA IILGCIIGAVLGMINGLLITKGKMAPFIATLATMTVFRGLTLVYTDGNPITGLGTNYG FQMFGRGYFLGIPVPAITMVLAFVILWVLLHKTPFGRRTYAIGGNEKAALISGIKVTR VKVMIYSLAGLLSALAGAILTSRLHSAQPTAGESYELDAIAAVVLGGTSLSGGRGRIV GTLIGVLIIGTLNNGLNLLGVSSFYQLVVKGIVILIAVLLDRKKSA*" /label="rbsC CDS" gene 3220074..3221042 /gene="rbsC" /locus_tag="BSU_35950" /old_locus_tag="BSU35950" /label="rbsC gene" CDS 3221054..3221971 /gene="rbsB" /locus_tag="BSU_35960" /old_locus_tag="BSU35960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (ribose-binding lipoprotein)" /protein_id="NP_391477.1" /db_xref="EnsemblGenomes-Gn:BSU35960" /db_xref="EnsemblGenomes-Tr:CAB15613" /db_xref="GOA:P36949" /db_xref="InterPro:IPR025997" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10881" /db_xref="UniProtKB/Swiss-Prot:P36949" /translation="MKKAVSVILTLSLFLLTACSLEPPQWAKPSNSGNKKEFTIGLSV STLNNPFFVSLKKGIEKEAKKRGMKVIIVDAQNDSSKQTSDVEDLIQQGVDALLINPT DSSAISTAVESANAVGVPVVTIDRSAEQGKVETLVASDNVKGGEMAAAFIADKLGKGA KVAELEGVPGASATRERGSGFHNIADQKLQVVTKQSADFDRTKGLTVMENLLQGHPDI QAVFAHNDEMALGALEAINSSGKDILVIGFDGNKDALASIKDRKLSATVAQQPELIGK LATEAADDILHGKKVQKTISAPLKLETQK*" /label="rbsB CDS" gene 3221054..3221971 /gene="rbsB" /locus_tag="BSU_35960" /old_locus_tag="BSU35960" /label="rbsB gene" promotor_-35 3221980..3221986 /Source="Nicolas_upshift_promotors" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3222001..3222019 /Source="Nicolas_upshift_promotors" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3222003 /Source="Nicolas_upshifts" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="upshifts" CDS 3222053..3222589 /gene="ywsB" /locus_tag="BSU_35970" /old_locus_tag="BSU35970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cell wall binding enzyme" /protein_id="NP_391478.1" /db_xref="EnsemblGenomes-Gn:BSU35970" /db_xref="EnsemblGenomes-Tr:CAB15614" /db_xref="GOA:P96729" /db_xref="InterPro:IPR003646" /db_xref="InterPro:IPR036028" /db_xref="SubtiList:BG12530" /db_xref="UniProtKB/Swiss-Prot:P96729" /translation="MNKPTKLFSTLALAAGMTAAAAGGAGTIHAQQPETTVSIDDLYS YPIDSYLVSAEALNVRTKPSASSQKADTLHLGDSLKLISFSNADWAKVKYKNGKTGFV STHYIVKAATTVKTKTKTKVYTSADGKSIKTLPADTSVSFLGWSKTNKGGFDFDWVFV DYGGTTGYMKTKDLHMTK*" /label="ywsB CDS" gene 3222053..3222589 /gene="ywsB" /locus_tag="BSU_35970" /old_locus_tag="BSU35970" /label="ywsB gene" downshifts 3222572 /Source="Nicolas_upshifts" /id="D1857" /incds=0 /nref=187 /ntot=255 /MaxReadThrough="5.87246" /MaxDrop="7.38203" /score="26.4284327" /energy="-19" /TU="U2817" /idTUdmin="U2814" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" S_feature 3222617..3222727 /Source="Nicolas_S_feature" /locus_tag="new_3707708_3707818" /HighExp="Etha, M9-stat, Sw, M40t90, G150, B60, T0.30H, M0t90, T1.30H, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1383" promotor_-35 3222696..3222702 /Source="Nicolas_upshift_promotors" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3222717..3222728 /Source="Nicolas_upshift_promotors" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3222729 /Source="Nicolas_upshifts" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="upshifts" CDS 3222745..3223041 /gene="ywsA" /locus_tag="BSU_35980" /old_locus_tag="BSU35980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11782522" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391479.1" /db_xref="EnsemblGenomes-Gn:BSU35980" /db_xref="EnsemblGenomes-Tr:CAB15615" /db_xref="InterPro:IPR024997" /db_xref="SubtiList:BG12529" /db_xref="UniProtKB/Swiss-Prot:P96728" /translation="MDQFEAAYESYKARQTTADQENVPSGKEEIIAVRRNEEDNIIAV KTNTGRELDYPTALSEAKSGKLAHVDVFHKYGRDILRSEPDGIKENNLSELPDF*" /label="ywsA CDS" gene 3222745..3223041 /gene="ywsA" /locus_tag="BSU_35980" /old_locus_tag="BSU35980" /label="ywsA gene" S_feature 3223042..3223694 /Source="Nicolas_S_feature" /locus_tag="new_3708133_3708785" /HighExp="Etha, M9-stat, S5, S7, S6, Sw, S8, B60, G150, S4" /AntisenseName="ywrO" /AntisenseCor="-0.23279201478213099" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1384" CDS complement(3223081..3223608) /gene="ywrO" /locus_tag="BSU_35990" /old_locus_tag="BSU35990" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11782522, 14697229, 17768344; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitroreductase (unknown substrate)" /protein_id="NP_391480.1" /db_xref="EnsemblGenomes-Gn:BSU35990" /db_xref="EnsemblGenomes-Tr:CAB15616" /db_xref="GOA:P80871" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG12528" /db_xref="UniProtKB/Swiss-Prot:P80871" /translation="MKILVLAVHPHMETSVVNKAWAEELSKHDNITVRDLYKEYPDEA IDVAKEQQLCEEYDRIVFQFPLYWYSSPPLLKKWQDLVLTYGWAFGSEGNALHGKELM LAVSTGSEAEKYQAGGANHYSISELLKPFQATSNLIGMKYLPPYVFYGVNYAAAEDIS HSAKRLAEYIQQPFV*" /label="ywrO CDS" gene complement(3223081..3223608) /gene="ywrO" /locus_tag="BSU_35990" /old_locus_tag="BSU35990" /label="ywrO gene" downshifts complement(3223091) /Source="Nicolas_upshifts" /id="D1858" /incds=0 /nref=48 /ntot=208 /MaxReadThrough="3.48831" /MaxDrop="4.56453" /score="1.41593376" /energy="-17.4" /TU="U2819" /idTUdmin="U2821" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3223628..3223647) /Source="Nicolas_upshift_promotors" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3223641) /Source="Nicolas_upshifts" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="upshifts" downshifts 3223652 /Source="Nicolas_upshifts" /id="D1859" /incds=0 /nref=26 /ntot=56 /MaxReadThrough="0.805200000000001" /MaxDrop="4.7199" /score="10.409416" /energy="-6.8" /TU="NA" /idTUdmin="U2817" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 complement(3223661..3223668) /Source="Nicolas_upshift_promotors" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3223707) /Source="Nicolas_upshifts" /id="D1860" /incds=0 /nref=20 /ntot=149 /MaxReadThrough="4.85403" /MaxDrop="6.46739" /score="-8.02974492" /energy="-5" /TU="U2821" /idTUdmin="U2821" /TUdmin="-616" /isTUend="FALSE" /label="downshifts" CDS complement(3223708..3224475) /gene="alsD" /locus_tag="BSU_36000" /old_locus_tag="BSU36000" /EC_number="4.1.1.5" /function="16.8: Protect" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7685336, 10972805, 12363365, 17183216, 21531833, 26454865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7685336, 10972805, 12363365, 17183216, 21531833, 26454865; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-acetolactate decarboxylase" /protein_id="NP_391481.1" /db_xref="EnsemblGenomes-Gn:BSU36000" /db_xref="EnsemblGenomes-Tr:CAB15617" /db_xref="GOA:Q04777" /db_xref="InterPro:IPR005128" /db_xref="SubtiList:BG10472" /db_xref="UniProtKB/Swiss-Prot:Q04777" /translation="MKRESNIQVLSRGQKDQPVSQIYQVSTMTSLLDGVYDGDFELSE IPKYGDFGIGTFNKLDGELIGFDGEFYRLRSDGTATPVQNGDRSPFCSFTFFTPDMTH KIDAKMTREDFEKEINSMLPSRNLFYAIRIDGLFKKVQTRTVELQEKPYVPMVEAVKT QPIFNFDNVRGTIVGFLTPAYANGIAVSGYHLHFIDEGRNSGGHVFDYVLEDCTVTIS QKMNMNLRLPNTADFFNANLDNPDFAKDIETTEGSPE*" /label="alsD CDS" gene complement(3223708..3224475) /gene="alsD" /locus_tag="BSU_36000" /old_locus_tag="BSU36000" /label="alsD gene" CDS complement(3224537..3226249) /gene="alsS" /locus_tag="BSU_36010" /old_locus_tag="BSU36010" /EC_number="2.2.1.6" /function="16.8: Protect" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10972805, 12363365, 17183216, 7685336, 25393087, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972805, 12363365, 17183216, 7685336, 25393087, 25355936; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-acetolactate synthase" /protein_id="NP_391482.2" /db_xref="EnsemblGenomes-Gn:BSU36010" /db_xref="EnsemblGenomes-Tr:CAB15618" /db_xref="GOA:Q04789" /db_xref="InterPro:IPR000399" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR012782" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10471" /db_xref="UniProtKB/Swiss-Prot:Q04789" /translation="MTKATKEQKSLVKNRGAELVVDCLVEQGVTHVFGIPGAKIDAVF DALQDKGPEIIVARHEQNAAFMAQAVGRLTGKPGVVLVTSGPGASNLATGLLTANTEG DPVVALAGNVIRADRLKRTHQSLDNAALFQPITKYSVEVQDVKNIPEAVTNAFRIASA GQAGAAFVSFPQDVVNEVTNTKNVRAVAAPKLGPAADDAISAAIAKIQTAKLPVVLVG MKGGRPEAIKAVRKLLKKVQLPFVETYQAAGTLSRDLEDQYFGRIGLFRNQPGDLLLE QADVVLTIGYDPIEYDPKFWNINGDRTIIHLDEIIADIDHAYQPDLELIGDIPSTINH IEHDAVKVEFAEREQKILSDLKQYMHEGEQVPADWKSDRAHPLEIVKELRNAVDDHVT VTCDIGSHAIWMSRYFRSYEPLTLMISNGMQTLGVALPWAIGASLVKPGEKVVSVSGD GGFLFSAMELETAVRLKAPIVHIVWNDSTYDMVAFQQLKKYNRTSAVDFGNIDIVKYA ESFGATGLRVESPDQLADVLRQGMNAEGPVIIDVPVDYSDNINLASDKLPKEFGELMK TKAL*" /label="alsS CDS" gene complement(3224537..3226249) /gene="alsS" /locus_tag="BSU_36010" /old_locus_tag="BSU36010" /label="alsS gene" promotor_-35 3225148..3225157 /Source="Nicolas_upshift_promotors" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3225171..3225190 /Source="Nicolas_upshift_promotors" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3225171 /Source="Nicolas_upshifts" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3226303..3226322) /Source="Nicolas_upshift_promotors" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3226308) /Source="Nicolas_upshifts" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3226328..3226335 /Source="Nicolas_upshift_promotors" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3226337..3226341) /Source="Nicolas_upshift_promotors" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3226349..3226368 /Source="Nicolas_upshift_promotors" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3226359 /Source="Nicolas_upshifts" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="upshifts" CDS 3226407..3227315 /gene="alsR" /locus_tag="BSU_36020" /old_locus_tag="BSU36020" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10809684, 10972805, 12363365, 15978075, 17183216, 7685336, 22178965, 23576037, 23695583, 23836140" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 10972805, 12363365, 15978075, 17183216, 7685336, 22178965, 23576037, 23695583, 23836140; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator controlling alsSD, ictEP expression (LysR family)" /protein_id="NP_391483.1" /db_xref="EnsemblGenomes-Gn:BSU36020" /db_xref="EnsemblGenomes-Tr:CAB15619" /db_xref="GOA:Q04778" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10470" /db_xref="UniProtKB/Swiss-Prot:Q04778" /translation="MELRHLQYFIAVAEELHFGKAARRLNMTQPPLSQQIKQLEEEVG VTLLKRTKRFVELTAAGEIFLNHCRMALMQIGQGIELAQRTARGEQGLLVIGFVGSAT YEFLPPIVREYRKKFPSVKIELREISSSRQQEELLKGNIDIGILHPPLQHTALHIETA QSSPCVLALPKQHPLTSKESITIEDLRDEPIITVAKEAWPTLYMDFIQFCEQAGFRPN IVQEATEYQMVIGLVSAGIGMTFVPSSAKKLFNLDVTYRKMDQIQLNAEWVIAYRKDN HNPLIKHFIHISNCQQTRTKESDAGT*" /label="alsR CDS" gene 3226407..3227315 /gene="alsR" /locus_tag="BSU_36020" /old_locus_tag="BSU36020" /label="alsR gene" promotor_-35 3227383..3227391 /Source="Nicolas_upshift_promotors" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3227393..3227525 /Source="Nicolas_S_feature" /locus_tag="new_3712484_3712616" /HighExp="BT, S8, B36, S7, G/S, S6, Pyr, B60, Etha, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.14666000000000001" /TUshortSig="SigK, SigA" /TUshortPSig="0.896, 0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1385" upshifts 3227393 /Source="Nicolas_upshifts" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3227405..3227424 /Source="Nicolas_upshift_promotors" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3227526..3228854 /gene="ywrK" /locus_tag="BSU_36030" /old_locus_tag="BSU36030" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/H+ antiporter" /protein_id="NP_391484.1" /db_xref="EnsemblGenomes-Gn:BSU36030" /db_xref="EnsemblGenomes-Tr:CAB15620" /db_xref="GOA:O05224" /db_xref="InterPro:IPR000802" /db_xref="SubtiList:BG12527" /db_xref="UniProtKB/Swiss-Prot:O05224" /translation="MLAFFVTMIFIFWRPKGLNEAIPATFGALMVLLCGSVSLADLGE IGTKVTGASVTILATMIMAIALESFGFFYWVAAKLLQQSKGSGIKLFWLTNLLCFLMT IFLNNDGSILITTPILLLVLKYLGLKKHQKAPYLLSGVLIATASSAPIGVSNIVNLIS LKIIGMDLYLHTAMMFVPSMMGLIFMTCLLFMFFYKRLPKSLPDIPGHFQSLRHRRYH PLHSPSAPLPERNQTKIMLFVLAFVFLVRMSLFAASYTGISVPLVAVIGSFILLSWRW IYFKTSPRDLLYKSPWHIFIFAFTMYVLIYGLHNIGFTELLVSYFEPVVSGSLAHATF ASGISTSVFSNLFNNHPALMISTFTLTEMTLNPSTTKIIYLANIIGSDIGSLLLPMGT LATLIWMHILKQHDESISWGEYIKTTIIIIPLTVLFTLTCLYFWISWLFL*" /label="ywrK CDS" gene 3227526..3228854 /gene="ywrK" /locus_tag="BSU_36030" /old_locus_tag="BSU36030" /label="ywrK gene" downshifts 3228845 /Source="Nicolas_upshifts" /id="D1861" /incds=0 /nref=16 /ntot=32 /MaxReadThrough="1.63489" /MaxDrop="6.12455" /score="-6.14091334" /energy="-11.9" /TU="NA" /idTUdmin="U2823" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3228911..3229588) /gene="ywrJ" /locus_tag="BSU_36040" /old_locus_tag="BSU36040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14762006, 22882546" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391485.1" /db_xref="EnsemblGenomes-Gn:BSU36040" /db_xref="EnsemblGenomes-Tr:CAB15621" /db_xref="InterPro:IPR020139" /db_xref="InterPro:IPR020173" /db_xref="SubtiList:BG12526" /db_xref="UniProtKB/Swiss-Prot:O05223" /translation="MKGLNQFLNTDVEVVISGDTRFVGTLIDIGQDIFVIFDGCNYLY IPLLHLHQINKAKIVTSTEKPFLINPEDPMIEAETQAFSYRNTLNKVKGQFIEVYVTG GRSIHGYVTNVLNDYIVFFSPVFKILFISMHHLKWFTPYSTEQTPYTLDNSQLPVVPS KVPLVRNFEEQIKKNIGELVIFDMGEVPEKVGLLKGVSNNIIELINASGEPVIWKLNH LKTMHLP*" /label="ywrJ CDS" gene complement(3228911..3229588) /gene="ywrJ" /locus_tag="BSU_36040" /old_locus_tag="BSU36040" /label="ywrJ gene" downshifts complement(3228921) /Source="Nicolas_upshifts" /id="D1862" /incds=0 /nref=14 /ntot=28 /MaxReadThrough="1.74629" /MaxDrop="5.1172" /score="-4.02447737" /energy="-9.5" /TU="NA" /idTUdmin="U2824" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3229648..3230790) /gene="cotB" /locus_tag="BSU_36050" /old_locus_tag="BSU36050" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8755863, 10559171, 11737650, 14762006, 19933362, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755863, 10559171, 11737650, 14762006, 19933362, 27185916; Product type s : structure" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_391486.1" /db_xref="EnsemblGenomes-Gn:BSU36050" /db_xref="EnsemblGenomes-Tr:CAB15622" /db_xref="GOA:P07789" /db_xref="SubtiList:BG10491" /db_xref="UniProtKB/Swiss-Prot:P07789" /translation="MSKRRMKYHSNNEISYYNFLHSMKDKIVTVYRGGPESKKGKLTA VKSDYIALQAEKKIIYYQLEHVKSITEDTNNSTTTIETEEMLDADDFHSLIGHLINQS VQFNQGGPESKKGRLVWLGDDYAALNTNEDGVVYFNIHHIKSISKHEPDLKIEEQTPV GVLEADDLSEVFKSLTHKWVSINRGGPEAIEGILVDNADGHYTIVKNQEVLRIYPFHI KSISLGPKGSYKKEDQKNEQNQEDNNDKDSNSFISSKSYSSSKSSKRSLKSSDDQSSK SGRSSRSKSSSKSSKRSLKSSDYQSSKSGRSSRSKSSSKSSKRSLKSSDYQSSKSSKR SPRSSDYQSSRSPGYSSSIKSSGKQKEDYSYETIVRTIDYHWKRKF*" /label="cotB CDS" gene complement(3229648..3230790) /gene="cotB" /locus_tag="BSU_36050" /old_locus_tag="BSU36050" /label="cotB gene" promotor_-10 complement(3230827..3230846) /Source="Nicolas_upshift_promotors" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3230835) /Source="Nicolas_upshifts" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3230837..3230917) /Source="Nicolas_S_feature" /locus_tag="new_3715928_3716008_c" /HighExp="S6, S7, S8, S5, BT, B36, S4, G/S, Pyr, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.142, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1386" promotor_-35 complement(3230860..3230868) /Source="Nicolas_upshift_promotors" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3230918..3232006) /gene="cotH" /locus_tag="BSU_36060" /old_locus_tag="BSU36060" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14762006, 25115591, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762006, 25115591, 27185916; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein kinase" /protein_id="NP_391487.1" /db_xref="EnsemblGenomes-Gn:BSU36060" /db_xref="EnsemblGenomes-Tr:CAB15623" /db_xref="GOA:Q45535" /db_xref="InterPro:IPR014867" /db_xref="SubtiList:BG11791" /db_xref="UniProtKB/Swiss-Prot:Q45535" /translation="MKNQSNLPLYQLFVHPKDLRELKKDIWDDDPVPAVMKVNQKRLD IDIAYRGSHIRDFKKKSYHISFYQPKTFRGAREIHLNAEYKDPSLMRNKLSLDFFSEL GTLSPKAEFAFVKMNGKNEGVYLELESVDEYYLAKRKLADGAIFYAVDDDANFSLMSD LERETKTSLELGYEKKTGTEEDDFYLQDMIFKINTVPKAQFKSEVTKHVDVDKYLRWL AGIVFTSNYDGFVHNYALYRSGETGLFEVIPWDYDATWGRDIHGERMAADYVRIQGFN TLTARILDESEFRKSYKRLLEKTLQSLFTIEYMEPKIMAMYERIRPFVLMDPYKKNDI ERFDREPDVICEYIKNRSQYLKDHLSIL*" /label="cotH CDS" gene complement(3230918..3232006) /gene="cotH" /locus_tag="BSU_36060" /old_locus_tag="BSU36060" /label="cotH gene" S_feature complement(3232007..3232120) /Source="Nicolas_S_feature" /locus_tag="new_3717098_3717211_c" /HighExp="S6, S8, S7, S5, BT, B36, Pyr, G/S, S4, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.142, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1387" promotor_-35 3232062..3232071 /Source="Nicolas_upshift_promotors" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3232084..3232103 /Source="Nicolas_upshift_promotors" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3232097 /Source="Nicolas_upshifts" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3232120) /Source="Nicolas_upshifts" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3232124..3232138) /Source="Nicolas_upshift_promotors" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3232147..3232151) /Source="Nicolas_upshift_promotors" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3232147..3232734 /gene="cotG" /locus_tag="BSU_36070" /old_locus_tag="BSU36070" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 14762006, 15621419, 22720735, 25115591, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 14762006, 15621419, 22720735, 25115591, 27185916; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="spore morphogenetic protein" /protein_id="NP_391488.1" /db_xref="EnsemblGenomes-Gn:BSU36070" /db_xref="EnsemblGenomes-Tr:CAB15624" /db_xref="GOA:P39801" /db_xref="SubtiList:BG11017" /db_xref="UniProtKB/Swiss-Prot:P39801" /translation="MGHYSHSDIEEAVKSAKKEGLKDYLYQEPHGKKRSHKKSHRTHK KSRSHKKSYCSHKKSRSHKKSFCSHKKSRSHKKSYCSHKKSRSHKKSYRSHKKSRSYK KSYRSYKKSRSYKKSCRSYKKSRSYKKSYCSHKKKSRSYKKSCRTHKKSYRSHKKYYK KPHHHCDDYKRHDDYDSKKEYWKDGNCWVVKKKYK*" /label="cotG CDS" gene 3232147..3232734 /gene="cotG" /locus_tag="BSU_36070" /old_locus_tag="BSU36070" /label="cotG gene" CDS 3232235..3232714 /locus_tag="BSU_36079" /old_locus_tag="BSU36079" /function="14.1: Surface structures" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="doubtful CDS (putative in frame frameshift)" /protein_id="YP_009514005.1" /translation="MEKNAVIKSRTALTKNLAAIKNHTALTKNLAVTKNHSVLTKNLA ATKNHTALTRNLAATKNRTVLTKNLAAIKNLTVLTKNLVAIKNLAVLTKNLAATKSLT VLTRKNLAAIRSHAAHTKNLIVPIRNTTKNRTTTATTTKDTMIMTAKKNTGKTAIAG* " /label="doubtful CDS (putative in frame frameshift)" gene 3232235..3232714 /locus_tag="BSU_36079" /old_locus_tag="BSU36079" /label="gene" S_feature complement(3232618..3232815) /Source="Nicolas_S_feature" /locus_tag="new_3717709_3717906_c" /HighExp="S5, S6, S4, B60, S3, nit, G/S, SMMPr, S8, ferm" /AntisenseName="cotG" /AntisenseCor="0.60092819988141299" /AntisenseRegPval="-27.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1388" downshifts 3232651 /Source="Nicolas_upshifts" /id="D1863" /incds=1 /nref=1 /ntot=54 /MaxReadThrough="7.80801" /MaxDrop="2.7794" /score="17.1895651" /energy="-10.7" /TU="U2825" /idTUdmin="U2825" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" downshifts complement(3232661) /Source="Nicolas_upshifts" /id="D1864" /incds=1 /nref=3 /ntot=23 /MaxReadThrough="4.99409" /MaxDrop="6.67733" /score="-1.37249416" /energy="-5.2" /TU="U2827" /idTUdmin="U2824" /TUdmin="-3740" /isTUend="FALSE" /label="downshifts" downshifts 3232720 /Source="Nicolas_upshifts" /id="D1865" /incds=0 /nref=41 /ntot=80 /MaxReadThrough="4.68169" /MaxDrop="5.35584" /score="17.1895651" /energy="-10.7" /TU="U2825" /idTUdmin="U2825" /TUdmin="-85" /isTUend="FALSE" /label="downshifts" downshifts 3232799 /Source="Nicolas_upshifts" /id="D1866" /incds=0 /nref=4 /ntot=17 /MaxReadThrough="2.30708" /MaxDrop="3.92552" /score="17.1895651" /energy="-10.7" /TU="NA" /idTUdmin="U2825" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3232814..3232833) /Source="Nicolas_upshift_promotors" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3232820) /Source="Nicolas_upshifts" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3232842..3232849 /Source="Nicolas_upshift_promotors" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3232846..3232855) /Source="Nicolas_upshift_promotors" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3232864..3232883 /Source="Nicolas_upshift_promotors" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3232870 /Source="Nicolas_upshifts" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="upshifts" CDS 3232908..3233525 /gene="ywrF" /locus_tag="BSU_36080" /old_locus_tag="BSU36080" /EC_number="1.14.13.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavin-binding monooxygenase" /protein_id="NP_391489.1" /db_xref="EnsemblGenomes-Gn:BSU36080" /db_xref="EnsemblGenomes-Tr:CAB15625" /db_xref="GOA:O05220" /db_xref="InterPro:IPR002563" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12525" /db_xref="UniProtKB/Swiss-Prot:O05220" /translation="MYIFQADQLSAKDTYKLLSGTVIPRPIAFVTTLSSGGAVNAAPF SFYNVVSSDPPLLSISVNRTEGRQKDTARNAVENGEFVVHVSDEAIIEDINETAASLR PDESELTRTSLHPVESKAVSVPGIKEARVRFECKLERHITFDNDQGITTADLLIGRVV CFHLDEKVYDAEKGYILTDELKPASRLAGNHYAKLGEEFTLIRPS*" /label="ywrF CDS" gene 3232908..3233525 /gene="ywrF" /locus_tag="BSU_36080" /old_locus_tag="BSU36080" /label="ywrF gene" S_feature 3233526..3233626 /Source="Nicolas_S_feature" /locus_tag="new_3718617_3718717" /HighExp="Etha, dia5, Diami, dia15, Lbtran, LBGtran, LPhT, M40t45, M40t90, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1389" downshifts 3233583 /Source="Nicolas_upshifts" /id="D1867" /incds=0 /nref=11 /ntot=56 /MaxReadThrough="4.52989" /MaxDrop="4.48979" /score="-1.9002322" /energy="-14.9" /TU="U2828" /idTUdmin="U2828" /TUdmin="-454" /isTUend="FALSE" /label="downshifts" promotor_-35 3233652..3233661 /Source="Nicolas_upshift_promotors" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3233673..3233688 /Source="Nicolas_upshift_promotors" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3233674 /Source="Nicolas_upshifts" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="upshifts" CDS 3233703..3234038 /gene="ywrE" /locus_tag="BSU_36090" /old_locus_tag="BSU36090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391490.1" /db_xref="EnsemblGenomes-Gn:BSU36090" /db_xref="EnsemblGenomes-Tr:CAB15626" /db_xref="GOA:O05219" /db_xref="InterPro:IPR025441" /db_xref="SubtiList:BG12524" /db_xref="UniProtKB/Swiss-Prot:O05219" /translation="MTNFWILMLIAITISLASQFFIKKKYGIDKSGWRYKHVSNTHKW IEITLLILFVFSLSFFPVEYLLLLFFIVIDSIRIFMEWHYRPEDKQYMYHIVEVSLMF MLLIYVCTL*" /label="ywrE CDS" gene 3233703..3234038 /gene="ywrE" /locus_tag="BSU_36090" /old_locus_tag="BSU36090" /label="ywrE gene" promotor_-10 complement(3233994..3234012) /Source="Nicolas_upshift_promotors" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3234003) /Source="Nicolas_upshifts" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3234027..3234032) /Source="Nicolas_upshift_promotors" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3234037 /Source="Nicolas_upshifts" /id="D1868" /incds=0 /nref=5 /ntot=153 /MaxReadThrough="5.64855" /MaxDrop="3.64569" /score="-1.9002322" /energy="-14.9" /TU="U2829" /idTUdmin="U2828" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3234043..3235620) /gene="hpxW" /locus_tag="BSU_36100" /old_locus_tag="BSU36100" /EC_number="3.5.1.126" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12823818, 14762019, 19935659, 27303801, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxamate amidohydrolase" /protein_id="NP_391491.1" /db_xref="EnsemblGenomes-Gn:BSU36100" /db_xref="EnsemblGenomes-Tr:CAB15627" /db_xref="GOA:O05218" /db_xref="InterPro:IPR000101" /db_xref="InterPro:IPR029055" /db_xref="SubtiList:BG12523" /db_xref="UniProtKB/Swiss-Prot:O05218" /translation="MNKSVIGTKQMVVSPHYLASQAGNRILDKGGNAFDAAVAVSACL AVVYPHMTGLGGDSFWLTFHQETKAVKVYNGSGRSGKNVTRDVYKGKSAIPLRGIDSA ITVPGMVDSWDAVLKEYGRLSLADVLEPARDYAQNGFPVSADQCRHTEKNIELLASTP YTADIFTRRGKAPVPGERFVQKELADSLNLIAEKGRSAFYEGDLAQRIVSHLQNNGSY MTIDDFKAHRGEWAAPVSSDYRGYSVYQAPPNSQGFTGLLTLNILENYDFTQIEHGSF EYYHVLVEALKKSFLDRDAVLTDPAFADIPLERLLDKRYAKQLAEEIGYLAIPAESRP VGSDTAYAAVIDADGNAVSFIQSLYFEFGSAVTAGDTGILLQNRGSFFSLDENHVNTL EPRKRTFHTLMPAMVCKGGKPKILYGTQGGEGQPQTQTAIITRMLDYGMHPQQAISEP RWVWGRTWGEEYEGLRVEGRFTDKTIQKLKDSGHLVEVVGDYDPLMGQAAAIKVDEEG FLQGGADPRGDGAAVGI*" /label="hpxW CDS" gene complement(3234043..3235620) /gene="hpxW" /locus_tag="BSU_36100" /old_locus_tag="BSU36100" /label="hpxW gene" S_feature 3234082..3235793 /Source="Nicolas_S_feature" /locus_tag="new_3719173_3720884" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, T3.30H, T3.0H, T-0.40H, T0.0H, Salt" /AntisenseName="ywrD" /AntisenseCor="0.153519829066777" /AntisenseRegPval="-1.9" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1390" promotor_-35 3235771..3235778 /Source="Nicolas_upshift_promotors" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3235789..3235808 /Source="Nicolas_upshift_promotors" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3235795 /Source="Nicolas_upshifts" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="upshifts" CDS 3235834..3236310 /gene="chrS" /locus_tag="BSU_36110" /old_locus_tag="BSU36110" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23989926; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional negative regulator of chromate transport (Lrp/AsnC family)" /protein_id="NP_391492.1" /db_xref="EnsemblGenomes-Gn:BSU36110" /db_xref="EnsemblGenomes-Tr:CAB15628" /db_xref="GOA:O05217" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12522" /db_xref="UniProtKB/Swiss-Prot:O05217" /translation="MSHEYQIPNLVLDETDKQILTILHEEGRISYTDLGKRVDLSRVA VQARINQLIEAGVIEKFTAVINPAKIGIHVSVFFNVEVEPQFLEEVALKLEEEPAVTS LYHMTGPSKLHMHGIFTNDQEMEEFLTKRLYPLRGVVSVDCQMLIKRYKSRMGMKL*" /label="chrS CDS" gene 3235834..3236310 /gene="chrS" /locus_tag="BSU_36110" /old_locus_tag="BSU36110" /label="chrS gene" CDS 3236324..3236917 /gene="chrB" /locus_tag="BSU_36120" /old_locus_tag="BSU36120" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23989926; Product type t: transporter" /codon_start=1 /transl_table=11 /product="chromate transporter subunit N" /protein_id="NP_391493.1" /db_xref="EnsemblGenomes-Gn:BSU36120" /db_xref="EnsemblGenomes-Tr:CAB15629" /db_xref="GOA:O05216" /db_xref="InterPro:IPR003370" /db_xref="SubtiList:BG12521" /db_xref="UniProtKB/Swiss-Prot:O05216" /translation="MKNHPYRDMTAAMVRTGILGFGGGPSVIPLIRHEAVNKYKWIDD DEFGEILAIANALPGPIATKMAAYLGFKLKGTLGAIVAILAHILPTCLAMVGLFAAVN VLSHSAIVAGMIGAVTPVIAVMLGIMAYEFGQKALKGFGWVTGILFFIIAFIGLQTLQ INPGLVIIIFLAYGAFHFKLKDKITNKHSKDKGMSAS*" /label="chrB CDS" gene 3236324..3236917 /gene="chrB" /locus_tag="BSU_36120" /old_locus_tag="BSU36120" /label="chrB gene" CDS 3236914..3237450 /gene="chrA" /locus_tag="BSU_36130" /old_locus_tag="BSU36130" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23989926; Product type t: transporter" /codon_start=1 /transl_table=11 /product="chromate transporter subunit C" /protein_id="NP_391494.1" /db_xref="EnsemblGenomes-Gn:BSU36130" /db_xref="EnsemblGenomes-Tr:CAB15630" /db_xref="GOA:O05215" /db_xref="InterPro:IPR003370" /db_xref="SubtiList:BG12520" /db_xref="UniProtKB/Swiss-Prot:O05215" /translation="MISIYLFMAFFIANLLGYGGGPASIPLMFEEVVNRYSWLSNDQF SNMLALANALPGPIATKIAAYVGYSAGGWPGFLIALIATVVPSALALIVLLRIIQRFR QSPVIKGMTLSVQPVIAVMMLILTWQIGADGIKAIGWVQSIVITGISLLAMTKFKMHP AFLIIAAFLYGGLVIPYL*" /label="chrA CDS" gene 3236914..3237450 /gene="chrA" /locus_tag="BSU_36130" /old_locus_tag="BSU36130" /label="chrA gene" downshifts 3237431 /Source="Nicolas_upshifts" /id="D1869" /incds=0 /nref=4 /ntot=90 /MaxReadThrough="0.0513700000000004" /MaxDrop="3.46649" /score="29.5508265" /energy="-8.6" /TU="NA" /idTUdmin="U2829" /TUdmin=28 /isTUend="FALSE" /label="downshifts" CDS complement(3237477..3237698) /gene="ywqO" /locus_tag="BSU_36140" /old_locus_tag="BSU36140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391495.1" /db_xref="EnsemblGenomes-Gn:BSU36140" /db_xref="EnsemblGenomes-Tr:CAB15631" /db_xref="SubtiList:BG12519" /db_xref="UniProtKB/Swiss-Prot:P96727" /translation="MKFLLSVIAGLLILALYLFWKVQPPVWIQVETNSSQLKQSVRMA GTTLQVKHMIKSDAGEETAVISNGISGLK*" /label="ywqO CDS" gene complement(3237477..3237698) /gene="ywqO" /locus_tag="BSU_36140" /old_locus_tag="BSU36140" /label="ywqO gene" upshifts 3237645 /Source="Nicolas_upshifts" /id="U2832" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.297702297702298" /psig="0.447552447552448" /xcortree=1475 /SigmaFactorBS="cttcaactgggacgaattggtttcaacttgtatccaaacagg aggctggaccttccaaaataaatagAGtgcaagaatcagcaagccagcaatgaccgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3237652..3237653 /Source="Nicolas_upshift_promotors" /id="U2832" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.297702297702298" /psig="0.447552447552448" /xcortree=1475 /SigmaFactorBS="cttcaactgggacgaattggtttcaacttgtatccaaacagg aggctggaccttccaaaataaatagAGtgcaagaatcagcaagccagcaatgaccgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3237695..3238240) /gene="ywqN" /locus_tag="BSU_36150" /old_locus_tag="BSU36150" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391496.1" /db_xref="EnsemblGenomes-Gn:BSU36150" /db_xref="EnsemblGenomes-Tr:CAB15632" /db_xref="GOA:P96726" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR029039" /db_xref="PDB:1RLI" /db_xref="SubtiList:BG12518" /db_xref="UniProtKB/Swiss-Prot:P96726" /translation="MKIAVINGGTRSGGNTDVLAEKAVQGFDAEHIYLQKYPIQPIED LRHAQGGFRPVQDDYDSIIERILQCHILIFATPIYWFGMSGTLKLFIDRWSQTLRDPR FPDFKQQMSVKQAYVIAVGGDNPKIKGLPLIQQFEHIFHFMGMSFKGYVLGEGNRPGD ILRDHQALSAASRLLKRSDAI*" /label="ywqN CDS" gene complement(3237695..3238240) /gene="ywqN" /locus_tag="BSU_36150" /old_locus_tag="BSU36150" /label="ywqN gene" promotor_-35 3238257..3238264 /Source="Nicolas_upshift_promotors" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3238279..3238298 /Source="Nicolas_upshift_promotors" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3238283 /Source="Nicolas_upshifts" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="upshifts" CDS 3238363..3239244 /gene="ywqM" /locus_tag="BSU_36160" /old_locus_tag="BSU36160" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391497.1" /db_xref="EnsemblGenomes-Gn:BSU36160" /db_xref="EnsemblGenomes-Tr:CAB15633" /db_xref="GOA:P96725" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12517" /db_xref="UniProtKB/Swiss-Prot:P96725" /translation="MELKQLITFITAAEHVNFTLTAKMLNYAQSSVTSQIKSLEEEIG TPLFERLGKRLILTEAGKTFKSYAQKIIALTEEAKMATNQVRETTGTLKIGATESQCT YRLPPIIKEFKQAFPQVKLIFKPYISNEQAKEQLLQGQLDITFILDVNRMEDALHVES LIQDEIKMVAANDHPFPADLPVTLKDLQNETLLLTEDGCSYRTLFENNLHDSGIYPNK LEFVSIEAIKQCVMAGLGIGILPEMTVKDDIAAGRMKELNWQSDCPVFTQLAWHKDKW MSAPLKAFIDLTRKTFK*" /label="ywqM CDS" gene 3238363..3239244 /gene="ywqM" /locus_tag="BSU_36160" /old_locus_tag="BSU36160" /label="ywqM gene" CDS complement(3239329..3240045) /gene="nfi" /locus_tag="BSU_36170" /old_locus_tag="BSU36170" /EC_number="3.1.21.7" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1692969, 22056936, 27530626" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1692969, 22056936, 27530626; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease V" /protein_id="NP_391498.2" /db_xref="EnsemblGenomes-Gn:BSU36170" /db_xref="EnsemblGenomes-Tr:CAB15634" /db_xref="GOA:P96724" /db_xref="InterPro:IPR007581" /db_xref="PDB:3GA2" /db_xref="SubtiList:BG12516" /db_xref="UniProtKB/Swiss-Prot:P96724" /translation="MKVFDVHKFDMKKEQDFLQVQFNLKNRINLSPTIHPDSINTCAG VDLAYWEQDGEPYGVCCIIVIDADTKEVIEKVHSMGRISVPYVSGFLAFRELPLIIEA AKKLETEPDVFLFDGNGYLHYNHMGVATHAAFFLGKPTIGIAKTYLKIKGCDFVTPEI EVGAYTDIIIDGEVYGRALRTRRDVKPIFLSCGNYIDLDSSYQITMSLINQESRLPIP VRLADLETHVLRTFYQKNHV*" /label="nfi CDS" gene complement(3239329..3240045) /gene="nfi" /locus_tag="BSU_36170" /old_locus_tag="BSU36170" /label="nfi gene" downshifts complement(3239349) /Source="Nicolas_upshifts" /id="D1870" /incds=0 /nref=44 /ntot=216 /MaxReadThrough="1.91774" /MaxDrop="3.62442" /score="12.1019223" /energy="-7.4" /TU="NA" /idTUdmin="U2834" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3240055..3240519) /gene="rttO" /locus_tag="BSU_36180" /old_locus_tag="BSU36180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease antitoxin" /protein_id="NP_391499.1" /db_xref="EnsemblGenomes-Gn:BSU36180" /db_xref="EnsemblGenomes-Tr:CAB15635" /db_xref="InterPro:IPR011652" /db_xref="SubtiList:BG12515" /db_xref="UniProtKB/Swiss-Prot:P96723" /translation="MENEYDMKSIKEKGVDFEDLWFSSVSDEILDNPEDENGQPFTGL AYELYPNGQIIYFTKYKNGLAHGLTCEFYENGNKKSEKEYRYGQLHGISIIWFENGRK KSEQQYEHSILISEKNWDEEGNLLNKYEIDTDSPHFEILESRRETHINLGRE*" /label="rttO CDS" gene complement(3240055..3240519) /gene="rttO" /locus_tag="BSU_36180" /old_locus_tag="BSU36180" /label="rttO gene" CDS complement(3240509..3242317) /gene="rttN" /locus_tag="BSU_36190" /old_locus_tag="BSU36190" /EC_number="3.1.-.-" /function="15.8: Toxin production and resistance" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease toxin" /protein_id="NP_391500.1" /db_xref="EnsemblGenomes-Gn:BSU36190" /db_xref="EnsemblGenomes-Tr:CAB15636" /db_xref="GOA:P96722" /db_xref="InterPro:IPR006829" /db_xref="InterPro:IPR025968" /db_xref="InterPro:IPR027797" /db_xref="SubtiList:BG12514" /db_xref="UniProtKB/Swiss-Prot:P96722" /translation="MSKVFESKSLIEEAKSRKKQYETLEEQLNTLKKAFQGVADLGDN FKGNGADNIKDFFQGQAEIVDSWLTLVSAQIAFLNGISGDIKDQELNDSYVETSFLDH ELPNGDLKASEIVSAHKEEIDSILSGISDIIDLDMYTLDDYADKMGDAQKIRRDTITA VDKLDESLTTEYQNLESLDNAVLTKYSVLMQATSNGKSASPMYYDKKAFHSNEVYKSV IEVENQGTTYIDAKTQQAEARRLQEKAEEEANKPWYEKTWDGVCNFTGEVTGYYDYKR ATEGVDPVTGEKLSTAERVTAGAMAAAGFIPVVGWAGRAFKGGKAIYKTGKAAIAAEH ALDAYKTGKSLDILKMTEMGAYGLVASNGFSEAVTGRDMFGNKVSEEKRKQGALEAIT IIGGAGLAHYFDRLYQKNAPYVNKVSNESLISNIAKTTEEKQTRLQYLRNKHGVLSKE DLHHRINLRAEVLNELSRIKSSGLTKKQRGPAVAGVLDKKTGNYYFGINNIDGKPPKV LHPLIHDRIVNMPTELKEGYIKTSGAGSHAEVNALNEALLQRPDADLKDLMVYVVSAR KINKKMPEGVPMPRCPHCEYITQNTNYIPEALKYGK*" /label="rttN CDS" gene complement(3240509..3242317) /gene="rttN" /locus_tag="BSU_36190" /old_locus_tag="BSU36190" /label="rttN gene" CDS complement(3242336..3242596) /gene="ywqI" /locus_tag="BSU_36200" /old_locus_tag="BSU36200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391501.1" /db_xref="EnsemblGenomes-Gn:BSU36200" /db_xref="EnsemblGenomes-Tr:CAB15637" /db_xref="InterPro:IPR020299" /db_xref="SubtiList:BG12513" /db_xref="UniProtKB/Swiss-Prot:P96721" /translation="MSEIKLKYDTVIKTLDSVKDALADVSIGAAGSNGKNSLDYTKKY HEREENIKTMLGDYKKAVQKNIEDTKDNVDSLKEQDEAIAVK*" /label="ywqI CDS" gene complement(3242336..3242596) /gene="ywqI" /locus_tag="BSU_36200" /old_locus_tag="BSU36200" /label="ywqI gene" CDS complement(3242606..3243028) /gene="ywqH" /locus_tag="BSU_36210" /old_locus_tag="BSU36210" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15101989" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391502.1" /db_xref="EnsemblGenomes-Gn:BSU36210" /db_xref="EnsemblGenomes-Tr:CAB15638" /db_xref="InterPro:IPR020326" /db_xref="InterPro:IPR031681" /db_xref="SubtiList:BG12512" /db_xref="UniProtKB/Swiss-Prot:P96720" /translation="MGYESMLADIKSSLNGKISDVEDKIEKLKKAKKDIDTLQEEAIT EIKEIVKPELGKHWTGTKADDFDKGREEAKSEASKIVNDKYNEYMASINGKIFDLEWD KAKYASELFIANGAADLLKKGEEFAEEVGNTISKLKWW*" /label="ywqH CDS" gene complement(3242606..3243028) /gene="ywqH" /locus_tag="BSU_36210" /old_locus_tag="BSU36210" /label="ywqH gene" S_feature complement(3243029..3243111) /Source="Nicolas_S_feature" /locus_tag="new_3728120_3728202_c" /HighExp="T2.30H, T4.0H, T5.0H, T3.0H, T3.30H, T1.30H, T2.0H, S4, T-0.40H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1391" promotor_-10 complement(3243103..3243122) /Source="Nicolas_upshift_promotors" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3243111) /Source="Nicolas_upshifts" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3243135..3243142) /Source="Nicolas_upshift_promotors" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3243245..3243370) /locus_tag="BSU_36215" /old_locus_tag="BSU36215" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514006.1" /translation="MTKSDMADQMKNINMNNKLSAERGRSTTSASFKCLYNYDIR*" /label="hypothetical protein CDS" gene complement(3243245..3243370) /locus_tag="BSU_36215" /old_locus_tag="BSU36215" /label="gene" S_feature complement(3243288..3243419) /Source="Nicolas_S_feature" /locus_tag="new_3728379_3728510_c" /HighExp="HiOs, BI, M9-tran, T-2.40H, MG 150, Sw, M9-exp, S1, T-3.40H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.19133600000000001" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1392" downshifts complement(3243331) /Source="Nicolas_upshifts" /id="D1871" /incds=0 /nref=29 /ntot=208 /MaxReadThrough="3.03928" /MaxDrop="3.47153" /score="16.9931891" /energy="-8.4" /TU="NA" /idTUdmin="U2835" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3243420..3244205) /gene="ywqG" /locus_tag="BSU_36220" /old_locus_tag="BSU36220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391503.1" /db_xref="EnsemblGenomes-Gn:BSU36220" /db_xref="EnsemblGenomes-Tr:CAB15639" /db_xref="InterPro:IPR015315" /db_xref="InterPro:IPR035948" /db_xref="PDB:1PV5" /db_xref="SubtiList:BG12511" /db_xref="UniProtKB/Swiss-Prot:P96719" /translation="MNHLPEKMRPYRDLLEKSAKEYVKLNVRKGKTGRYDSKIAGDPY FPKHETYPTDENGQPMKLLAQINFSHIPQLDGYPSSGILQFYISVHDDVYGLNFDDRC EQKNFRVIYFENIVENDDELVSDFSFIGTGECDFPILSEAAVEPVKSSEWVLPTDFQF EQYTGMETMEFFGQFGEDEEDIYNELAENGFGHKIGGYASFTQHDPREYAYKEHTIML LQIDSDDDIDSMWGDVGIANFFITPEDLRKKDFSNVLYNWDCS*" /label="ywqG CDS" gene complement(3243420..3244205) /gene="ywqG" /locus_tag="BSU_36220" /old_locus_tag="BSU36220" /label="ywqG gene" S_feature complement(3244206..3244321) /Source="Nicolas_S_feature" /locus_tag="new_3729297_3729412_c" /HighExp="HiOs, T-1.40H, T-2.40H, T-3.40H, M9-tran, MG 150, SMM, GM 150, T0.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1393" promotor_-10 complement(3244314..3244333) /Source="Nicolas_upshift_promotors" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3244321) /Source="Nicolas_upshifts" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3244347..3244354) /Source="Nicolas_upshift_promotors" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3244397..3245719) /gene="uglF" /locus_tag="BSU_36230" /old_locus_tag="BSU36230" /EC_number="1.1.1.22" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12970183, 15741737, 15866923, 16415592" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 15741737, 15866923, 16415592; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose dehydrogenase" /protein_id="NP_391504.1" /db_xref="EnsemblGenomes-Gn:BSU36230" /db_xref="EnsemblGenomes-Tr:CAB15640" /db_xref="GOA:P96718" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR021157" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12510" /db_xref="UniProtKB/Swiss-Prot:P96718" /translation="MNITVIGTGYVGLVTGVSLSEIGHHVTCIDIDAHKIDEMRKGIS PIFEPGLEELMRKNTADGRLNFETSYEKGLAQADIIFIAVGTPQKSDGHANLEQITDA AKRIAKHVKRDTVVVTKSTVPVGTNDLINGLITEHLAEPVSISVASNPEFLREGSAIY DTFHGDRIVIGTADEKTANTLEELFRPFQIPIYQTDIRSAEMIKYASNAFLATKISFI NEISNICEKVGADIEAVAYGMGQDKRIGSQFLKAGIGYGGSCFPKDTNALVQIAGNVE HDFELLKSVIKVNNNQQAMLVDKALNRLGGVTGKTIALLGLSFKPNTDDMREAPSIVI ADRLAALDARIRAYDPIAVSHAKHVLPQAVEYKETIEEAVKGSDAVMILTDWADIKQF PLAAYQDLMETPLIFDGRNCYTLDEALAAGVEYYSVGRKAVVPSGAIQ*" /label="uglF CDS" gene complement(3244397..3245719) /gene="uglF" /locus_tag="BSU_36230" /old_locus_tag="BSU36230" /label="uglF gene" downshifts complement(3244409) /Source="Nicolas_upshifts" /id="D1872" /incds=0 /nref=137 /ntot=221 /MaxReadThrough="3.29767" /MaxDrop="6.20721" /score="16.9931891" /energy="-8.4" /TU="NA" /idTUdmin="U2836" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(3245753) /Source="Nicolas_upshifts" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3245755..3245880) /Source="Nicolas_S_feature" /locus_tag="new_3730846_3730971_c" /HighExp="dia15, H2O2, Diami, dia5, LBGstat, Paraq, LBGexp, G180, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.13453899999999999" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1394" promotor_-10 complement(3245755..3245773) /Source="Nicolas_upshift_promotors" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3245789..3245794) /Source="Nicolas_upshift_promotors" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3245860..3245879) /Source="Nicolas_upshift_promotors" /id="U2837" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.817182817182817" /psig="0.993006993006993" /xcortree=1828 /SigmaFactorBS="agaagaaaattgtttggttttttttaacagccgattctcatt tcaccactttctttttgagAGCGATATAATAGTGTATTGtatggttgaatcacatttc a" /listShort="S1394, ywqF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3245880) /Source="Nicolas_upshifts" /id="U2837" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.817182817182817" /psig="0.993006993006993" /xcortree=1828 /SigmaFactorBS="agaagaaaattgtttggttttttttaacagccgattctcatt tcaccactttctttttgagAGCGATATAATAGTGTATTGtatggttgaatcacatttc a" /listShort="S1394, ywqF" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3245914..3246678) /gene="ptpZ" /locus_tag="BSU_36240" /old_locus_tag="BSU36240" /EC_number="3.1.3.48" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15866923, 16415592, 16549871, 21605684, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15866923, 16415592, 16549871, 21605684, 27148221; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein tyrosine-phosphatase" /protein_id="NP_391505.1" /db_xref="EnsemblGenomes-Gn:BSU36240" /db_xref="EnsemblGenomes-Tr:CAB15641" /db_xref="GOA:P96717" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR016667" /db_xref="PDB:3QY6" /db_xref="PDB:3QY7" /db_xref="SubtiList:BG12509" /db_xref="UniProtKB/Swiss-Prot:P96717" /translation="MIDIHCHILPAMDDGAGDSADSIEMARAAVRQGIRTIIATPHHN NGVYKNEPAAVREAADQLNKRLIKEDIPLHVLPGQEIRIYGEVEQDLAKRQLLSLNDT KYILIEFPFDHVPRYAEQLFYDLQLKGYIPVIAHPERNREIRENPSLLYHLVEKGAAS QITSGSLAGIFGKQLKAFSLRLVEANLIHFVASDAHNVKTRNFHTQEALYVLEKEFGS ELPYMLTENAELLLRNQTIFRQPPQPVKRRKLFGFF*" /label="ptpZ CDS" gene complement(3245914..3246678) /gene="ptpZ" /locus_tag="BSU_36240" /old_locus_tag="BSU36240" /label="ptpZ gene" downshifts complement(3246697) /Source="Nicolas_upshifts" /id="D1873" /incds=0 /nref=4 /ntot=152 /MaxReadThrough="3.17433" /MaxDrop="3.31415" /score="15.8630799" /energy="-9.3" /TU="U2838" /idTUdmin="U2838" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" CDS complement(3246731..3247444) /gene="ptkA" /locus_tag="BSU_36250" /old_locus_tag="BSU36250" /EC_number="2.7.10.2" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12970183, 15741737, 16415592, 16549871, 17367396, 20497499, 20815827, 23939619, 24493247, 26283769, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 15741737, 16415592, 16549871, 17367396, 20497499, 20815827, 23939619, 24493247, 26283769, 27148221; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="maintenance protein tyrosine kinase involved in biofilm formation" /protein_id="NP_391506.1" /db_xref="EnsemblGenomes-Gn:BSU36250" /db_xref="EnsemblGenomes-Tr:CAB15642" /db_xref="GOA:P96716" /db_xref="InterPro:IPR005702" /db_xref="InterPro:IPR025669" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12508" /db_xref="UniProtKB/Swiss-Prot:P96716" /translation="MALRKNRGSRMQRNVIAMTEPKSLNSEQYRTIRTNIEFASVDRQ MKSVMITSACPGEGKSTTAANLAVVFAQQGKKVLLIDADLRKPTVHTAFFLENTVGLT SVLLKKSSMEQAVQASNEKHLDVLTSGPIPPNPAELLSSKWMKELAYEACAAYDMVIF DTPPILAVADAQILGNVADGSVLVISSGKTEKEQAAKAKEALATCKSKLLGAIMNGKK LSKHSEYGYYGTKDNFMQK*" /label="ptkA CDS" gene complement(3246731..3247444) /gene="ptkA" /locus_tag="BSU_36250" /old_locus_tag="BSU36250" /label="ptkA gene" downshifts complement(3246748) /Source="Nicolas_upshifts" /id="D1874" /incds=0 /nref=10 /ntot=157 /MaxReadThrough="4.4352" /MaxDrop="4.08842" /score="15.8630799" /energy="-9.3" /TU="U2838" /idTUdmin="U2838" /TUdmin="-381" /isTUend="FALSE" /label="downshifts" CDS complement(3247434..3248180) /gene="tkmA" /locus_tag="BSU_36260" /old_locus_tag="BSU36260" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12970183, 23939619, 24493247, 26283769" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 23939619, 24493247, 26283769; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modulator of PtkA protein tyrosine kinase activity; modulation of biofilm formation" /protein_id="NP_391507.1" /db_xref="EnsemblGenomes-Gn:BSU36260" /db_xref="EnsemblGenomes-Tr:CAB15643" /db_xref="GOA:P96715" /db_xref="InterPro:IPR003856" /db_xref="InterPro:IPR032807" /db_xref="SubtiList:BG12507" /db_xref="UniProtKB/Swiss-Prot:P96715" /translation="MGESTSLKEILSTLTKRILLIMIVTAAATAAGGLISFFALTPIY ENSTQILVNQSKNERKEVQFNDVQTNLQLINTYNVIIKSPAILDEVIKEMGLSMTSQE LNDKITVSSEQDSQVVNISVRDENAETAAHIANTIASVFQDKITSIMNVDNVSILSKA EVSEHPSPVSPKPLLNIAIAFAAGLAGSIGLAFLLEHLDNTIKSEEQLESLLDIPVLG TVSTIANEQKTAKTLQGFQSEKTGSGHFGA*" /label="tkmA CDS" gene complement(3247434..3248180) /gene="tkmA" /locus_tag="BSU_36260" /old_locus_tag="BSU36260" /label="tkmA gene" promotor_-10 complement(3248212..3248231) /Source="Nicolas_upshift_promotors" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3248224) /Source="Nicolas_upshifts" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3248248..3248251) /Source="Nicolas_upshift_promotors" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3248414..3248557) /gene="ywzD" /locus_tag="BSU_36269" /old_locus_tag="BSU36269" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097792.1" /db_xref="EnsemblGenomes-Gn:BSU36269" /db_xref="EnsemblGenomes-Tr:CAX52703" /db_xref="UniProtKB/Swiss-Prot:C0H3S3" /translation="MSEKKLNQEEFLKILMHAHEIGEQSSEMTTKEMLENLISHIKNG YAT*" /label="ywzD CDS" gene complement(3248414..3248557) /gene="ywzD" /locus_tag="BSU_36269" /old_locus_tag="BSU36269" /label="ywzD gene" downshifts complement(3248435) /Source="Nicolas_upshifts" /id="D1875" /incds=0 /nref=221 /ntot=264 /MaxReadThrough="2.76798" /MaxDrop="8.13076" /score="15.8630799" /energy="-9.3" /TU="U2839" /idTUdmin="U2841" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3248558..3248643) /Source="Nicolas_S_feature" /locus_tag="new_3733649_3733734_c" /HighExp="S6, S8, S7, MG-0.2, S5, M9-stat, MG-0.1, MG 25, T0.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigD, SigK" /TUshortPSig="0.275, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1395" misc_feature complement(3248633..3248644) /Source="Nicolas_upshift_promotors" /id="U2839" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.290709290709291" /psig="0.274725274725275" /xcortree=1473 /SigmaFactorBS="caacacatcggccttaaaaagtttttcctaaaaaaggacata aaaaataggatgtgtcgAATGATGTATTAgagattgcaaattgataaccagcatcata t" /listShort="S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3248643) /Source="Nicolas_upshifts" /id="U2839" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.290709290709291" /psig="0.274725274725275" /xcortree=1473 /SigmaFactorBS="caacacatcggccttaaaaagtttttcctaaaaaaggacata aaaaataggatgtgtcgAATGATGTATTAgagattgcaaattgataaccagcatcata t" /listShort="S1395, ywzD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3248645..3248875) /Source="Nicolas_S_feature" /locus_tag="new_3733736_3733966_c" /HighExp="S6, S8, S7, S5, BT, Cold, LBGstat, LPhT, Pyr, C30" /AntisenseName="ywqB" /AntisenseCor="3.4267833233812203E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigK" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1396" promotor_-35 3248682..3248686 /Source="Nicolas_upshift_promotors" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3248702..3248721 /Source="Nicolas_upshift_promotors" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3248711 /Source="Nicolas_upshifts" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="upshifts" CDS 3248761..3250371 /gene="ywqB" /locus_tag="BSU_36270" /old_locus_tag="BSU36270" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative replication initiation protein" /protein_id="NP_391508.2" /db_xref="EnsemblGenomes-Gn:BSU36270" /db_xref="EnsemblGenomes-Tr:CAB15644" /db_xref="GOA:P96714" /db_xref="InterPro:IPR007527" /db_xref="SubtiList:BG12506" /db_xref="UniProtKB/Swiss-Prot:P96714" /translation="MLQNMISKDDVLASAEQLKELLPYNEENVQLIKKALILYRQDSV YRLQAVSPTEVTAYVQDVVPVRVTLNLFVIVKSGCSCPSGRICRHMLAVFLYVYAMFE RVGTFTEYWLEREKLEESKELVRRQFQEKVLPNEESLSSWLAFFDSEFSLWQARTPEG SQNMQGLYYGYLSALKKHAPNKPELKSLYQIHSAIAVWLRMFTLIEAGKLNPEQDFYS LNPYVEQLMDTIYSSIDKLKTYALSFALDPFLDKTPDVIRHLLLKEEIFQYERIRVFG EIWSALLSRPKWVAREQEILKKEAGRRFSPELQFGRLHLEFLQKNDDVIFEEADQFPP EALPYTFQWLSEMTAKKDWKRLKTWYQQIEPIAMGYTKLDKPFKEIRDVIGELFLLLN AYVQQTNDQALFERFAAGCLPYTFTEYSHHLYEKKRYAEWIEIHSLVGFSINEMDKMM LKEIAASDPEALIPAYHREVAFFIDQKNRSSYKEAARYLKKLRTLYKKAKKQKVWERY IQLLSSHYKRLRALQEELQKGKLIDGES*" /label="ywqB CDS" gene 3248761..3250371 /gene="ywqB" /locus_tag="BSU_36270" /old_locus_tag="BSU36270" /label="ywqB gene" promotor_-10 complement(3248863..3248881) /Source="Nicolas_upshift_promotors" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3248875) /Source="Nicolas_upshifts" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3248877..3249051) /Source="Nicolas_S_feature" /locus_tag="new_3733968_3734142_c" /HighExp="S6, S8, S7, S5, BT, B36, G/S, Pyr, B60, C30" /AntisenseName="ywqB" /AntisenseCor="-0.10880748846525" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1397" promotor_-35 complement(3248895..3248902) /Source="Nicolas_upshift_promotors" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3249038..3249057) /Source="Nicolas_upshift_promotors" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3249051) /Source="Nicolas_upshifts" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3249071..3249079) /Source="Nicolas_upshift_promotors" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3250358..3253126 /gene="hepA" /locus_tag="BSU_36280" /old_locus_tag="BSU36280" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9507009, 9614128, 11751638, 17913745, 19282450; Product type f: factor" /codon_start=1 /transl_table=11 /product="ATPase involved in RNA remodelling DNA recombination and repair" /protein_id="NP_391509.1" /db_xref="EnsemblGenomes-Gn:BSU36280" /db_xref="EnsemblGenomes-Tr:CAB15645" /db_xref="GOA:P94593" /db_xref="InterPro:IPR000330" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR022138" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12505" /db_xref="UniProtKB/Swiss-Prot:P94593" /translation="MASLKEILIHVEQMEDGSFTLSAFDENEQPLPYSHMKKHLFQWH ESSFYGTFLEDVSFIGTTAVLLSPWMTVELLGKNSFNSFSSVQLTEETEPLIEAASTI YEFIADGDFMPDYDAWTNGVFRWKDRDNILEGFTAEWFSAAVQDYIQYDDDLREKWEH IKEKSPAVTTFRGHFLDEEDFLEGIGWIDDQSPFTVGLRLNEPDFDGDEWKIEMFLRD KKSGAVEFFDGLKSLKKSWQAYSDKIAREQDRFHRTVPWLSFDSGTTLISEEEAWIFL SEASETLVDMGVEILLPSWWQIVRDSNMMLKAKVSSSPRGESFVGMNALLDFNWRFAT NGIELTEAEFNELVASNRRLVNIRGQWVKIDPQFIKQMKRLMEKAESEGLHMSDILAR ELMDQQDGGLEDSDLIDTSAFAGIQFDLSKQLRSLIRKLTAAENLPEHKVSPSFKGTL RPYQKYGMNWLLFLRESGFGACLADDMGLGKTIQMIAYFLHVKESGRQKTPHLIIAPT SVLGNWQRELQTFAPDLSVALHYGPRRPKGDDFAAHYENADVVLTSYGLSHADTEELS SVTWNTICLDEAQNIKNAHTKQSRAIRKLKGLHHIALSGTPMENRLTELWSIFDFMNK GYLGSLTGFHKRYVLPIEKDRDEKRIGQLQQLIRPFLLRRTKRDEEVALNLPEKLEEK EFIPLSAEQASLYEQLVKDTFDHMTSLTGMQRKALILSMLGRLKQICDHPALYLKEEQ TELLAGRSVKLEKLLELMTAIRAQNESCLIFTQYIQMGNMMKRLLEKTFGEPVQFLNG SLSKQERDTLVEKFQRKEYPTLILSLKAGGTGLNLTAANHVIHYDRWWNPAVENQATD RAYRIGQERFVHVHKMITTGTIEEKIDVMLESKQTLNDQIIQSENWITELSTQELEEL FTLSATAQ*" /label="hepA CDS" gene 3250358..3253126 /gene="hepA" /locus_tag="BSU_36280" /old_locus_tag="BSU36280" /label="hepA gene" downshifts complement(3253175) /Source="Nicolas_upshifts" /id="D1876" /incds=0 /nref=9 /ntot=202 /MaxReadThrough="1.80101" /MaxDrop="4.14573" /score="30.708119" /energy="-14.4" /TU="U2843" /idTUdmin="U2844" /TUdmin=12 /isTUend="TRUE" /label="downshifts" CDS complement(3253252..3254109) /gene="ywpJ" /locus_tag="BSU_36290" /old_locus_tag="BSU36290" /EC_number="3.1.3.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 25848029; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatase of unidentified specificity (possibly promiscuous)" /protein_id="NP_391510.1" /db_xref="EnsemblGenomes-Gn:BSU36290" /db_xref="EnsemblGenomes-Tr:CAB15646" /db_xref="GOA:P94592" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:1NRW" /db_xref="SubtiList:BG12504" /db_xref="UniProtKB/Swiss-Prot:P94592" /translation="MKLIAIDLDGTLLNSKHQVSLENENALRQAQRDGIEVVVSTGRA HFDVMSIFEPLGIKTWVISANGAVIHDPEGRLYHHETIDKKRAYDILSWLESENYYYE VFTGSAIYTPQNGRELLDVELDRFRSANPEADLSVLKQAAEVQYSQSGFAYINSFQEL FEADEPIDFYNILGFSFFKEKLEAGWKRYEHAEDLTLVSSAEHNFELSSRKASKGQAL KRLAKQLNIPLEETAAVGDSLNDKSMLEAAGKGVAMGNAREDIKSIADAVTLTNDEHG VAHMMKHLL*" /label="ywpJ CDS" gene complement(3253252..3254109) /gene="ywpJ" /locus_tag="BSU_36290" /old_locus_tag="BSU36290" /label="ywpJ gene" CDS complement(3254115..3254891) /gene="glcR" /locus_tag="BSU_36300" /old_locus_tag="BSU36300" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11491085" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11491085; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (glucose repression ofcatabolic operons)" /protein_id="NP_391511.1" /db_xref="EnsemblGenomes-Gn:BSU36300" /db_xref="EnsemblGenomes-Tr:CAB15647" /db_xref="GOA:P94591" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12503" /db_xref="UniProtKB/Swiss-Prot:P94591" /translation="MYQEERLVAILDFLKQHNRITTEQICTLLQVSRDTARRDLVKLE EQNAIIRTRGGAILPTVHQKIQSYSGRLKTVSEEKNKIGRLAASLIHDGDRVILDAST TVQACAKHLNAVDCTVITNSINLADVLSDKEGIEIYLLGGKLEKEHRFLYGSSVIEKL SSYHVDKALIGVVGISEHGITIAHEEDGMVKRKMIQQAKQVIALADHSKLGSTSFYQY AELNEIDLLITDRLPNQAFCDLLDRNGVELLVTEQDEGKD*" /label="glcR CDS" gene complement(3254115..3254891) /gene="glcR" /locus_tag="BSU_36300" /old_locus_tag="BSU36300" /label="glcR gene" promotor_-10 complement(3254917..3254936) /Source="Nicolas_upshift_promotors" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3254939) /Source="Nicolas_upshifts" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3254941..3255013) /Source="Nicolas_S_feature" /locus_tag="new_3740032_3740104_c" /HighExp="C30, GM 150, T-4.40H, G/S, C90, S2, T-5.40H, T-3.40H, T-2.40H, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1398" promotor_-35 complement(3254951..3254958) /Source="Nicolas_upshift_promotors" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3255015..3255114) /Source="Nicolas_S_feature" /locus_tag="new_3740106_3740205_c" /HighExp="HiOs, S2, T-3.40H, T0.30H, C90, G/S, T1.0H, T0.0H, Pyr, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1399" downshifts complement(3255058) /Source="Nicolas_upshifts" /id="D1877" /incds=0 /nref=221 /ntot=258 /MaxReadThrough="3.81096" /MaxDrop="7.17295" /score="-7.00620083" /energy="-7.5" /TU="U2844" /idTUdmin="U2846" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(3255115..3255456) /gene="ssbB" /locus_tag="BSU_36310" /old_locus_tag="BSU36310" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14762004, 16009133, 16549871, 17630974, 25138221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762004, 16009133, 16549871, 17630974, 25138221; Product type f: factor" /codon_start=1 /transl_table=11 /product="single-strand DNA-binding protein" /protein_id="NP_391512.2" /db_xref="EnsemblGenomes-Gn:BSU36310" /db_xref="EnsemblGenomes-Tr:CAB15648" /db_xref="GOA:C0SPB6" /db_xref="InterPro:IPR000424" /db_xref="InterPro:IPR011344" /db_xref="InterPro:IPR012340" /db_xref="PDB:3VDY" /db_xref="SubtiList:BG12502" /db_xref="UniProtKB/Swiss-Prot:C0SPB6" /translation="MFNQVMLVGRLTKDPDLRYTSAGAAVAHVTLAVNRSFKNASGEI EADYVNCTLWRKTAENTALYCQKGSLVGVSGRIQTRSYENEEGVNVYVTEVLADTVRF MDPKPREKAAD*" /label="ssbB CDS" gene complement(3255115..3255456) /gene="ssbB" /locus_tag="BSU_36310" /old_locus_tag="BSU36310" /label="ssbB gene" promotor_-10 complement(3255478..3255497) /Source="Nicolas_upshift_promotors" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3255497) /Source="Nicolas_upshifts" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3255511..3255518) /Source="Nicolas_upshift_promotors" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3255533..3255916) /gene="ywpG" /locus_tag="BSU_36320" /old_locus_tag="BSU36320" /experiment="publication(s) with functional evidences, PMID:23060960" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23060960; Product type f: factor" /codon_start=1 /transl_table=11 /product="interaction partner of DynA" /protein_id="NP_391513.1" /db_xref="EnsemblGenomes-Gn:BSU36320" /db_xref="EnsemblGenomes-Tr:CAB15649" /db_xref="SubtiList:BG12501" /db_xref="UniProtKB/Swiss-Prot:P94589" /translation="MNQFRLKEIYIDGVPSESHLIQKEVTYMLSRKEVFEVHLNKKGR ISFLYETQDGMEQYKIKLSMPEKKLSFQWFAWDGSSYVRMNTQNWLTKQIFFRFLKST YFFKGKKQKMFLAEGKMKTKDKNRG*" /label="ywpG CDS" gene complement(3255533..3255916) /gene="ywpG" /locus_tag="BSU_36320" /old_locus_tag="BSU36320" /label="ywpG gene" promotor_-10 complement(3255938..3255957) /Source="Nicolas_upshift_promotors" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="promotor_-10" misc_feature 3255945..3255964 /Source="Nicolas_upshift_promotors" /id="U2845" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.502497502497502" /psig="0.973026973026973" /xcortree=3123 /SigmaFactorBS="aaatttcttttaaacgaaattgattcataccacatctctccg taatccatagtcagTTACAGTATAATGAAAAAATagaaattattaaatgtttcgctca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3255949 /Source="Nicolas_upshifts" /id="U2845" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.502497502497502" /psig="0.973026973026973" /xcortree=3123 /SigmaFactorBS="aaatttcttttaaacgaaattgattcataccacatctctccg taatccatagtcagTTACAGTATAATGAAAAAATagaaattattaaatgtttcgctca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3255958) /Source="Nicolas_upshifts" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="upshifts" promotor_-35 complement(3255972..3255979) /Source="Nicolas_upshift_promotors" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="promotor_-35" misc_feature 3256039..3256058 /Source="Nicolas_upshift_promotors" /id="U2847" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.818181818181818" /psig=1 /xcortree=1915 /SigmaFactorBS="tcgctcatacaaaattctttagccccaacattgcaggatttt ttcctcgaaaacgttTATGTTATAATGGAAGGCAAgaaaactttggaagtaatcgggg t" /listShort="ywpF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3256042 /Source="Nicolas_upshifts" /id="U2847" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.818181818181818" /psig=1 /xcortree=1915 /SigmaFactorBS="tcgctcatacaaaattctttagccccaacattgcaggatttt ttcctcgaaaacgttTATGTTATAATGGAAGGCAAgaaaactttggaagtaatcgggg t" /listShort="ywpF" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(3256091) /Source="Nicolas_upshifts" /id="D1878" /incds=0 /nref=2 /ntot=169 /MaxReadThrough="0.85282" /MaxDrop="4.02798" /score="27.231517" /energy="-14" /TU="NA" /idTUdmin="U2846" /TUdmin="-1034" /isTUend="FALSE" /label="downshifts" CDS 3256091..3256501 /gene="ywpF" /locus_tag="BSU_36330" /old_locus_tag="BSU36330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25663006" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391514.1" /db_xref="EnsemblGenomes-Gn:BSU36330" /db_xref="EnsemblGenomes-Tr:CAB15650" /db_xref="InterPro:IPR025573" /db_xref="SubtiList:BG12500" /db_xref="UniProtKB/Swiss-Prot:P94588" /translation="MKTFKLVDLNVERVDKEEQSIEQFPLIDGLIINKEDGENHWLIE ALVQKEHLSFFEQLQNSQSEAKVFVTITKKSNRPAQLTAAVKNIVKLEESIQVLLYGQ MVTRKQQGTETILESLVKEGYTGTKLIEAFKQKL*" /label="ywpF CDS" gene 3256091..3256501 /gene="ywpF" /locus_tag="BSU_36330" /old_locus_tag="BSU36330" /label="ywpF gene" S_feature 3256502..3256585 /Source="Nicolas_S_feature" /locus_tag="new_3741593_3741676" /HighExp="BC, LBGtran, T3.30H, Etha, T2.0H, Lbtran, M9-stat, T3.0H, dia5, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1400" downshifts 3256543 /Source="Nicolas_upshifts" /id="D1879" /incds=0 /nref=214 /ntot=260 /MaxReadThrough="1.83981" /MaxDrop="6.19197" /score="18.4023831" /energy="-14" /TU="NA" /idTUdmin="U2847" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3256641..3256949) /gene="ywpE" /locus_tag="BSU_36340" /old_locus_tag="BSU36340" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182, 21800427, 21906378; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sortase" /protein_id="NP_391515.1" /db_xref="EnsemblGenomes-Gn:BSU36340" /db_xref="EnsemblGenomes-Tr:CAB15651" /db_xref="GOA:P94587" /db_xref="InterPro:IPR005754" /db_xref="InterPro:IPR023365" /db_xref="SubtiList:BG12499" /db_xref="UniProtKB/Swiss-Prot:P94587" /translation="MRRDQKMGEGNYPLAGHHLKQKNLLFGPLENIKTGAQIVITDFK KDYIYSVTSKDIISEMDADVVEETNKKEITLITCDKAVKTEGRLVVKGELVDSFGHTN *" /label="ywpE CDS" gene complement(3256641..3256949) /gene="ywpE" /locus_tag="BSU_36340" /old_locus_tag="BSU36340" /label="ywpE gene" downshifts complement(3256642) /Source="Nicolas_upshifts" /id="D1880" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="0.11027" /MaxDrop="2.8132" /score="27.231517" /energy="-14" /TU="NA" /idTUdmin="U2849" /TUdmin=1540 /isTUend="FALSE" /label="downshifts" CDS 3257293..3258129 /gene="ywpD" /locus_tag="BSU_36350" /old_locus_tag="BSU36350" /function="16.12: Sense" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16740923; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative two-component sensor histidine kinase" /protein_id="NP_391516.1" /db_xref="EnsemblGenomes-Gn:BSU36350" /db_xref="EnsemblGenomes-Tr:CAB15652" /db_xref="GOA:P94586" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12498" /db_xref="UniProtKB/Swiss-Prot:P94586" /translation="MKIRERFSMVDLPVLIITAAIIGHDKYKAFHAGANDILQKPYHY SEFMARIQNLIMMKHTANQATRMEMAFLQSQIKPHFLYNVLNTIISLTHLDIEKAREV TEEFTNYLRMSFDFQNTSAISSFRHELSIINSYLSIEKTRFSNRLEVLFDIDEDIDFI LPPLMIQPLVENAVLHGVSKKRGGGWIKLTAKKQSKNEYHIKVEDNGPGITPEKQIDL LSTDFDRSVGLKNINQRLKHFCGSELMISSTPDAGTSVSMLIHLAETTGSPKELKDTE RT*" /label="ywpD CDS" gene 3257293..3258129 /gene="ywpD" /locus_tag="BSU_36350" /old_locus_tag="BSU36350" /label="ywpD gene" promotor_-35 3257509..3257516 /Source="Nicolas_upshift_promotors" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3257531..3257550 /Source="Nicolas_upshift_promotors" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3257534 /Source="Nicolas_upshifts" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3258128 /Source="Nicolas_upshifts" /id="D1881" /incds=0 /nref=13 /ntot=132 /MaxReadThrough="0.11837" /MaxDrop="3.37937" /score="9.16906941" /energy="-8.6" /TU="NA" /idTUdmin="U2848" /TUdmin=154 /isTUend="FALSE" /label="downshifts" CDS complement(3258176..3258568) /gene="mscL" /locus_tag="BSU_36360" /old_locus_tag="BSU36360" /function="16.1: Circulate" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12948773, 15063854, 15165739, 16897034, 22685134, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12948773, 15063854, 15165739, 16897034, 22685134, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="large conductance mechanosensitive channel protein" /protein_id="NP_391517.1" /db_xref="EnsemblGenomes-Gn:BSU36360" /db_xref="EnsemblGenomes-Tr:CAB15653" /db_xref="GOA:P94585" /db_xref="InterPro:IPR001185" /db_xref="InterPro:IPR019823" /db_xref="InterPro:IPR036019" /db_xref="SubtiList:BG12497" /db_xref="UniProtKB/Swiss-Prot:P94585" /translation="MWNEFKAFAMRGNIVDLAIGVVIGGAFGKIVTSLVNDIIMPLVG LLLGGLDFSGLSFTFGDAVVKYGSFIQTIVNFLIISFSIFIVIRTLNGLRRKKEAEEE AAEEAVDAQEELLKEIRDLLKQQAKSPE*" /label="mscL CDS" gene complement(3258176..3258568) /gene="mscL" /locus_tag="BSU_36360" /old_locus_tag="BSU36360" /label="mscL gene" downshifts complement(3258182) /Source="Nicolas_upshifts" /id="D1882" /incds=0 /nref=216 /ntot=255 /MaxReadThrough="2.23487" /MaxDrop="6.5103" /score="28.9904077" /energy="-11.4" /TU="NA" /idTUdmin="U2849" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3258641..3259066) /gene="fabZ" /locus_tag="BSU_36370" /old_locus_tag="BSU36370" /EC_number="4.2.1.59" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8910376, 12682299, 15194690, 15371447, 18093984, 22580319, 23322253, 27874013; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-hydroxyacyl-[acyl carrier protein] dehydratase" /protein_id="NP_391518.2" /db_xref="EnsemblGenomes-Gn:BSU36370" /db_xref="EnsemblGenomes-Tr:CAB15654" /db_xref="GOA:P94584" /db_xref="InterPro:IPR010084" /db_xref="InterPro:IPR013114" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG12496" /db_xref="UniProtKB/Swiss-Prot:P94584" /translation="MLDTQQIKEIIPHRYPFLLVDRITEVEEGKRAKGYKNVTANEEF FNGHFPQYPVMPGVLIVEALAQVGAVAMLIKEENRGRLAFFAGIDNCRFKKQVKPGDQ LHLEVEIIRARGTIGRGKGVATVDGEVVCEVELTFALGE*" /label="fabZ CDS" gene complement(3258641..3259066) /gene="fabZ" /locus_tag="BSU_36370" /old_locus_tag="BSU36370" /label="fabZ gene" promotor_-10 complement(3259127..3259146) /Source="Nicolas_upshift_promotors" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3259143) /Source="Nicolas_upshifts" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3259145..3259229) /Source="Nicolas_S_feature" /locus_tag="new_3744236_3744320_c" /HighExp="Diami, dia5, Cold, dia15, H2O2, C30, Etha, Oxctl, Paraq, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigD, SigA" /TUlongPSig="0.999, 0.837" /label="S1401" promotor_-35 complement(3259161..3259168) /Source="Nicolas_upshift_promotors" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3259208 /Source="Nicolas_upshifts" /id="U2850" /multdbtbs="SigA,SigX" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.988011988011988" /xcortree=3190 /SigmaFactorBS="gaattaatctctttttcaaccgcgctaaaatgtaaccaactg tcaatgagagccgtcaaaagtTATGATATGATAATTATAGAttttaccaatagcaaag a" /listShort="rapD, S1403" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3259211..3259230 /Source="Nicolas_upshift_promotors" /id="U2850" /multdbtbs="SigA,SigX" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.988011988011988" /xcortree=3190 /SigmaFactorBS="gaattaatctctttttcaaccgcgctaaaatgtaaccaactg tcaatgagagccgtcaaaagtTATGATATGATAATTATAGAttttaccaatagcaaag a" /listShort="rapD, S1403" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3259221..3259240) /Source="Nicolas_upshift_promotors" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="promotor_-10" upshifts complement(3259229) /Source="Nicolas_upshifts" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="upshifts" S_feature complement(3259231..3260315) /Source="Nicolas_S_feature" /locus_tag="new_3744322_3745406_c" /HighExp="Cold, C30, Lbstat, Glucon, Glu, Paraq, Pyr, H2O2, Fru, C90" /AntisenseName="rapD" /AntisenseCor="5.8390464430913601E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.837" /label="S1402" promotor_-35 complement(3259254..3259259) /Source="Nicolas_upshift_promotors" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="promotor_-35" CDS 3259258..3260322 /gene="rapD" /locus_tag="BSU_36380" /old_locus_tag="BSU36380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17227471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391519.1" /db_xref="EnsemblGenomes-Gn:BSU36380" /db_xref="EnsemblGenomes-Tr:CAB15655" /db_xref="GOA:P94583" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11967" /db_xref="UniProtKB/Swiss-Prot:P94583" /translation="MISKFIEKRMLNMLDEWYSAMSKRKMNHVCTLKEKIDQHLPKIK KNTKLWMRYQLFQARHQLLFENQNGLDSLFDGLYGLEDKMDDELKYYLYFFSGLYEMV KTAPKHAVHHFKKAEQYLAAIHNTFEAADLYYQTAGAYYLMKSPPLSVQYVKKALHIY LHQFGYIKKVITCKLLLAVNYIDQERYEKAEQLFKEIIKKTQQLHDENLLCHAYYNLG FLKATEKKDQEALLYFRKVLKNQEFEMNSPVSYLHCVYESVRALFKTGNITEAKAVLQ KGKELSEKVDIQTIYLKLKTLEALYTSAEDPYEQLLEYVLELEKIEAWVDLEVLLEDI TEYYKKKDDFEKAAFFIMRG*" /label="rapD CDS" gene 3259258..3260322 /gene="rapD" /locus_tag="BSU_36380" /old_locus_tag="BSU36380" /label="rapD gene" S_feature 3260323..3261207 /Source="Nicolas_S_feature" /locus_tag="new_3745414_3746298" /HighExp="M9-stat, T4.0H, T2.0H, T3.30H, T2.30H, T3.0H, T1.30H, T5.0H, T1.0H, T0.30H" /AntisenseName="flhP" /AntisenseCor="-0.32116112580252298" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1403" CDS complement(3260345..3261154) /gene="flhP" /locus_tag="BSU_36390" /old_locus_tag="BSU36390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:22730131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22730131; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar hook-basal body accessory protein" /protein_id="NP_391520.2" /db_xref="EnsemblGenomes-Gn:BSU36390" /db_xref="EnsemblGenomes-Tr:CAB15656" /db_xref="GOA:P39753" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="InterPro:IPR020013" /db_xref="SubtiList:BG10918" /db_xref="UniProtKB/Swiss-Prot:P39753" /translation="MLRSMLTASTTLNQLQQQIDTISSNLSNSNTTGYKAKDTNFSEL VRQQFDQVDEKNEEVAKARKTPPGLRLGVGAMMSSRLVSDQGSIQKTDRDLDIAFTSP YQYLQVNVNGNRQYTRDGALYVTPSAANANQLQLVTGNGYPVLDENGNTVNIDSSMKN ITINKNGTLTASDGNAVQRFNLGVVQVNNPQELKSEGNNLFSIDNAAAFEELNGANRQ NIGMQQGSLEMSNVDISEQMTDLITSQRSYQLNSRTITMGDQMLGLINSVR*" /label="flhP CDS" gene complement(3260345..3261154) /gene="flhP" /locus_tag="BSU_36390" /old_locus_tag="BSU36390" /label="flhP gene" downshifts complement(3260360) /Source="Nicolas_upshifts" /id="D1883" /incds=0 /nref=174 /ntot=256 /MaxReadThrough="4.65461" /MaxDrop="5.56507" /score="8.59904552" /energy="-7.4" /TU="U2853" /idTUdmin="U2854" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(3261188..3262000) /gene="flhO" /locus_tag="BSU_36400" /old_locus_tag="BSU36400" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1905667, 16621824, 22730131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1905667, 16621824, 22730131; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar basal-body accessory rod protein" /protein_id="NP_391521.1" /db_xref="EnsemblGenomes-Gn:BSU36400" /db_xref="EnsemblGenomes-Tr:CAB15657" /db_xref="GOA:P39752" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10917" /db_xref="UniProtKB/Swiss-Prot:P39752" /translation="MLKGLYTATSAMIAQQRRTEMLSNNIANANTSGYKADQGSMRAF PEMLLSRIESKSPAGTSRTEIGSVNTGVYMQELKPLFTQGSLKSTDQPTDIALIENQV PMSAETNEKAALFYPVQTADGIRYSKSSTFSLNENNQLTINGRPILSTDRQPITVDNE NFTVSENGTVTTNGRTAGQIDVRMAEDVRNLKRDGNDLYSTADGNDLPSAAGNNQVAY SLKQGVSELSNVDVTSAYTEMTEAYRSFEANQKVIQAYDKSMDKAANEIGKI*" /label="flhO CDS" gene complement(3261188..3262000) /gene="flhO" /locus_tag="BSU_36400" /old_locus_tag="BSU36400" /label="flhO gene" S_feature complement(3262001..3262080) /Source="Nicolas_S_feature" /locus_tag="new_3747092_3747171_c" /HighExp="C90, Lbtran, Cold, GM-0.2, GM 15, GM 10, C30, GM 90, GM-0.1, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="0.999, 0.837" /TUlongSig="NA" /TUlongPSig="NA" /label="S1404" promotor_-35 3262031..3262038 /Source="Nicolas_upshift_promotors" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3262052..3262071 /Source="Nicolas_upshift_promotors" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3262061 /Source="Nicolas_upshifts" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3262074..3262092) /Source="Nicolas_upshift_promotors" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="promotor_-10" upshifts complement(3262080) /Source="Nicolas_upshifts" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="upshifts" promotor_-35 complement(3262106..3262113) /Source="Nicolas_upshift_promotors" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="promotor_-35" CDS complement(3262163..3263164) /gene="mbl" /locus_tag="BSU_36410" /old_locus_tag="BSU36410" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11290328, 12530960, 14588250, 15745453, 17064365, 19659933, 21091501, 23879732, 27215790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11290328, 12530960, 14588250, 15745453, 17064365, 19659933, 21091501, 23879732, 27215790; Product type f: factor" /codon_start=1 /transl_table=11 /product="MreB-like morphogen" /protein_id="NP_391522.2" /db_xref="EnsemblGenomes-Gn:BSU36410" /db_xref="EnsemblGenomes-Tr:CAB15658" /db_xref="GOA:P39751" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10916" /db_xref="UniProtKB/Swiss-Prot:P39751" /translation="MFARDIGIDLGTANVLIHVKGKGIVLNEPSVVALDKNSGKVLAV GEEARRMVGRTPGNIVAIRPLKDGVIADFEVTEAMLKHFINKLNVKGLFSKPRMLICC PTNITSVEQKAIKEAAEKSGGKHVYLEEEPKVAAIGAGMEIFQPSGNMVVDIGGGTTD IAVISMGDIVTSSSIKMAGDKFDMEILNYIKREYKLLIGERTAEDIKIKVATVFPDAR HEEISIRGRDMVSGLPRTITVNSKEVEEALRESVAVIVQAAKQVLERTPPELSADIID RGVIITGGGALLNGLDQLLAEELKVPVLVAENPMDCVAIGTGVMLDNMDKLPKRKLS* " /label="mbl CDS" gene complement(3262163..3263164) /gene="mbl" /locus_tag="BSU_36410" /old_locus_tag="BSU36410" /label="mbl gene" downshifts complement(3262169) /Source="Nicolas_upshifts" /id="D1884" /incds=0 /nref=108 /ntot=240 /MaxReadThrough="5.6154" /MaxDrop="4.18076" /score="20.122637" /energy="-11.2" /TU="U2854" /idTUdmin="U2855" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" misc_feature complement(3263219..3263238) /Source="Nicolas_upshift_promotors" /id="U2854" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.837162837162837" /xcortree=799 /SigmaFactorBS="gttcataaaacatccgcaaaaatttgtaaagaacttattgtg cttccaactttttttctatatttTATGATAATATATATAATTAgggcacaatgtggat a" /listShort="mbl, S1404, flhO, flhP" /listLong="S1402, S1401, fabZ, mscL" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3263243) /Source="Nicolas_upshifts" /id="U2854" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.837162837162837" /xcortree=799 /SigmaFactorBS="gttcataaaacatccgcaaaaatttgtaaagaacttattgtg cttccaactttttttctatatttTATGATAATATATATAATTAgggcacaatgtggat a" /listShort="mbl, S1404, flhO, flhP" /listLong="S1402, S1401, fabZ, mscL" /label="upshifts" S_feature complement(3263245..3263329) /Source="Nicolas_S_feature" /locus_tag="new_3748336_3748420_c" /HighExp="S5, S6, S4, S7, S8, S3, B36, T5.0H, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1405" CDS complement(3263330..3263611) /gene="spoIIID" /locus_tag="BSU_36420" /old_locus_tag="BSU36420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9023218, 9324264, 15598884, 22720735, 24584501" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023218, 9324264, 15598884, 22720735, 24584501; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (stage III sporulation)" /protein_id="NP_391523.1" /db_xref="EnsemblGenomes-Gn:BSU36420" /db_xref="EnsemblGenomes-Tr:CAB15659" /db_xref="GOA:P15281" /db_xref="InterPro:IPR014208" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="PDB:2L0K" /db_xref="SubtiList:BG10408" /db_xref="UniProtKB/Swiss-Prot:P15281" /translation="MHDYIKERTIKIGKYIVETKKTVRVIAKEFGVSKSTVHKDLTER LPEINPDLANEVKEILDYHKSIRHLRGGEATKLKYKKDEILEGEPVQQS*" /label="spoIIID CDS" gene complement(3263330..3263611) /gene="spoIIID" /locus_tag="BSU_36420" /old_locus_tag="BSU36420" /label="spoIIID gene" CDS complement(3263626..3263736) /gene="usd" /locus_tag="BSU_36430" /old_locus_tag="BSU36430" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9023218; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative factor required for translation of spoIIID" /protein_id="NP_391524.1" /db_xref="EnsemblGenomes-Gn:BSU36430" /db_xref="EnsemblGenomes-Tr:CAB15660" /db_xref="SubtiList:BG11984" /db_xref="UniProtKB/Swiss-Prot:O32276" /translation="MGIFHKLTFKTIQRRSGIMNDSLQNTDLISHFSHPF*" /label="usd CDS" gene complement(3263626..3263736) /gene="usd" /locus_tag="BSU_36430" /old_locus_tag="BSU36430" /label="usd gene" promotor_-10 complement(3263767..3263785) /Source="Nicolas_upshift_promotors" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3263789) /Source="Nicolas_upshifts" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3263801..3263806) /Source="Nicolas_upshift_promotors" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3263882..3263888 /Source="Nicolas_upshift_promotors" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3263902..3263921 /Source="Nicolas_upshift_promotors" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3263918 /Source="Nicolas_upshifts" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="upshifts" CDS 3263961..3264374 /gene="ywoH" /locus_tag="BSU_36440" /old_locus_tag="BSU36440" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391525.1" /db_xref="EnsemblGenomes-Gn:BSU36440" /db_xref="EnsemblGenomes-Tr:CAB15661" /db_xref="GOA:P94578" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12495" /db_xref="UniProtKB/Swiss-Prot:P94578" /translation="MSYVNRHLIHQINQSARLIAKKANEQLEPFGLYSSQWSVLYCLR TIGPMTQKEIWSYLNVEAPTVTRTIKRLEENGWVQRRQGEDKREKLVVLTKEAEKKYE EINVKMLKFEEELLADFRDEDKEAFSHLFRMFLQQ*" /label="ywoH CDS" gene 3263961..3264374 /gene="ywoH" /locus_tag="BSU_36440" /old_locus_tag="BSU36440" /label="ywoH gene" CDS 3264396..3265586 /gene="ywoG" /locus_tag="BSU_36450" /old_locus_tag="BSU36450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391526.1" /db_xref="EnsemblGenomes-Gn:BSU36450" /db_xref="EnsemblGenomes-Tr:CAB15662" /db_xref="GOA:P94577" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12494" /db_xref="UniProtKB/Swiss-Prot:P94577" /translation="MKKADAIWTKDFIMVLLVNLFVFVFFYTFLTVLPIYTLQELGGT ESQGGLLISLFLLSAIITRPFSGAIVERFGKKRMAIVSMALFALSSFLYMPIHNFSLL LGLRFFQGIWFSILTTVTGAIAADIIPAKRRGEGLGYFAMSMNLAMAIGPFLGLNLMR VVSFPVFFTAFALFMVAGLLVSFLIKVPQSKDSGTTVFRFAFSDMFEKGALKIATVGL FISFCYSTVTSYLSVFAKSVDLSDISGYFFVCFAVTMMIARPFTGKLFDKVGPGIVIY PSILIFSVGLCMLSFTHSGLMLLLSGAVIGLGYGSIVPCMQTLAIQKSPAHRSGFATA TFFTFFDSGIAVGSYVFGLFVASAGFSAIYLTAGLFVLIALLLYTWSQKKPAEAEGKV SIAE*" /label="ywoG CDS" gene 3264396..3265586 /gene="ywoG" /locus_tag="BSU_36450" /old_locus_tag="BSU36450" /label="ywoG gene" CDS complement(3265677..3267083) /gene="ywoF" /locus_tag="BSU_36460" /old_locus_tag="BSU36460" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15266115, 16607952, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pectin lyase" /protein_id="NP_391527.1" /db_xref="EnsemblGenomes-Gn:BSU36460" /db_xref="EnsemblGenomes-Tr:CAB15663" /db_xref="GOA:P94576" /db_xref="InterPro:IPR006626" /db_xref="InterPro:IPR006633" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG12493" /db_xref="UniProtKB/Swiss-Prot:P94576" /translation="MRKWYFILLAGVLTSVILAFVYDKTKANEEGSGDYLYVSPNGSD QNEGTKEKPFRTLAHASEKAAAGTTVMIREGTYHETLDVKHSGTDGKPITFRNYENEN VVISGESVANAEYETPLIRIHDKHDIAISGLTIQDLSVSSEEATAIGIYVSGSSSHIA IKDNHIRGIKTTADEGNAHGIAVYGTGSMKDIRIEDNTVEKLTLGASEAVVLNGNIDG FTVAGNVVRNNNNIGIDLIGYEGTADKNDYVRNGVVENNTVYQNSTYGNPAYGDEYSA GGIYVDGGHDIEIKNNTVYDNDIGIEATSEHKGKYANAIQITDNKVYNNAYTGISIGG YDKKRGGTSNSLIARNIMYRNDTKGLYGGQLLLQYDTKNNTIEKNILTAGDSRLFIGN DFTENEGNTVNHNVYHKEADQDGIWMWKKKEYDSFSSYRKATKNDQQSIYADPMFRDE ASYDFSLDPDSPARPVIE*" /label="ywoF CDS" gene complement(3265677..3267083) /gene="ywoF" /locus_tag="BSU_36460" /old_locus_tag="BSU36460" /label="ywoF gene" downshifts complement(3265974) /Source="Nicolas_upshifts" /id="D1885" /incds=1 /nref=1 /ntot=78 /MaxReadThrough="5.28695" /MaxDrop="2.1962" /score="4.73902293" /energy="-22.3" /TU="U2857" /idTUdmin="U2857" /TUdmin="-924" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3267116..3267135) /Source="Nicolas_upshift_promotors" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3267134) /Source="Nicolas_upshifts" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3267150..3267153) /Source="Nicolas_upshift_promotors" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3267189..3268661) /gene="pucI" /locus_tag="BSU_36470" /old_locus_tag="BSU36470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039, 15849754, 16850406, 26967546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039, 15849754, 16850406, 26967546; Product type t : transporter" /codon_start=1 /transl_table=11 /product="allantoin permease" /protein_id="NP_391528.1" /db_xref="EnsemblGenomes-Gn:BSU36470" /db_xref="EnsemblGenomes-Tr:CAB15664" /db_xref="GOA:P94575" /db_xref="InterPro:IPR001248" /db_xref="InterPro:IPR012681" /db_xref="SubtiList:BG12492" /db_xref="UniProtKB/Swiss-Prot:P94575" /translation="MKLKESQQQSNRLSNEDLVPLGQEKRTWKAMNFASIWMGCIHNI PTYATVGGLIAIGLSPWQVLAIIITASLILFGALALNGHAGTKYGLPFPVIIRASYGI YGANIPALLRAFTAIMWLGIQTFAGSTALNILLLNMWPGWGEIGGEWNILGIHLSGLL SFVFFWAIHLLVLHHGMESIKRFEVWAGPLVYLVFGGMVWWAVDIAGGLGPIYSQPGK FHTFSETFWPFAAGVTGIIGIWATLILNIPDFTRFAETQKEQIKGQFYGLPGTFALFA FASITVTSGSQVAFGEPIWDVVDILARFDNPYVIVLSVITLCIATISVNVAANIVSPA YDIANALPKYINFKRGSFITALLALFTVPWKLMESATSVYAFLGLIGGMLGPVAGVMM ADYFIIRKRELSVDDLYSETGRYVYWKGYNYRAFAATMLGALISLIGMYVPVLKSLYD ISWFVGVLISFLFYIVLMRVHPPASLAIETVEHAQVRQAE*" /label="pucI CDS" gene complement(3267189..3268661) /gene="pucI" /locus_tag="BSU_36470" /old_locus_tag="BSU36470" /label="pucI gene" CDS complement(3268842..3270200) /gene="ywoD" /locus_tag="BSU_36480" /old_locus_tag="BSU36480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391529.1" /db_xref="EnsemblGenomes-Gn:BSU36480" /db_xref="EnsemblGenomes-Tr:CAB15665" /db_xref="GOA:P94574" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12491" /db_xref="UniProtKB/Swiss-Prot:P94574" /translation="MLSKKSRAVFLTAVASGTMLNPLNSSMISLALHSIQHEFHLSFT TVSWLISSFYLASAVAQPVTGKLGDLIGRKRLFLFGLILVAVSAIGAPFAPTFMTLLV MRLFQSVGSSAIYPSGVGLIRNHIHERQASALAVLSIFASAMTALGPTAGGFLIVWGG WPAIFIVNLPFIILSFLLGLYMFPKDQKKGAGIKTIIRQLDILGIVLFAGGIIFLLSF LLSFSTSPHAVEGVLGLLLLCAFVWRELKTDKPFIDVRLFKTQRNLSAVYVQFILLNV FFYCLFFGLPSYFQDEMHLSVQTSGLFMLFMSGMSIVVSPLTGKWIDRSGVVKPIFAG ALLMTAGAVLLTIFFINVQTIGKGLILSLLGIGYGLGNVALQAAMLETSPSNMVGTTS GLFQTCRYLGSILSSVILGILFGKEITAAHFDMMGIIMIIAGGASLLMAVRFAALMKT AS*" /label="ywoD CDS" gene complement(3268842..3270200) /gene="ywoD" /locus_tag="BSU_36480" /old_locus_tag="BSU36480" /label="ywoD gene" downshifts complement(3268856) /Source="Nicolas_upshifts" /id="D1886" /incds=0 /nref=58 /ntot=198 /MaxReadThrough="1.44148" /MaxDrop="4.13092" /score="20.2036192" /energy="-12.8" /TU="NA" /idTUdmin="U2858" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3270200..3270769) /gene="ywoC" /locus_tag="BSU_36490" /old_locus_tag="BSU36490" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme of isochorismatase family" /protein_id="NP_391530.2" /db_xref="EnsemblGenomes-Gn:BSU36490" /db_xref="EnsemblGenomes-Tr:CAB15666" /db_xref="GOA:P94573" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR016291" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG12490" /db_xref="UniProtKB/Swiss-Prot:P94573" /translation="MMNTLNIDFQKTALVIIDLQKGIVPIDQSGQVVPNAKKLVDEFR KHNGFISFVNVAFHDGADALKPQTDEPAQGGSGEMPADWAEFVPEIGVQDGDYTVTKR QWGAFFGTDLDLQLRRRGIDTIVLCGIATNIGVESTAREAFQLGYQQIFITDAMSTFS DEEHEATLRFIFPRIGKSRTTEEFLEQVK*" /label="ywoC CDS" gene complement(3270200..3270769) /gene="ywoC" /locus_tag="BSU_36490" /old_locus_tag="BSU36490" /label="ywoC gene" promotor_-10 complement(3270788..3270799) /Source="Nicolas_upshift_promotors" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3270806) /Source="Nicolas_upshifts" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3270813..3270819) /Source="Nicolas_upshift_promotors" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3270876..3271043) /locus_tag="BSU_36499" /old_locus_tag="BSU36499" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CCQ48605.1" /translation="MSYPALDGPPQIHGHFQAGTDRQQAGDEAMTPFMITVLAGLFVC TTCYYYIKEKS*" /label="hypothetical protein CDS" gene complement(3270876..3271043) /locus_tag="BSU_36499" /old_locus_tag="BSU36499" /pseudo /label="gene" CDS complement(3270953..3271417) /gene="ywoB" /locus_tag="BSU_36500" /old_locus_tag="BSU36500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21856850; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391531.1" /db_xref="EnsemblGenomes-Gn:BSU36500" /db_xref="EnsemblGenomes-Tr:CAB15667" /db_xref="GOA:P94572" /db_xref="InterPro:IPR020218" /db_xref="SubtiList:BG12489" /db_xref="UniProtKB/Swiss-Prot:P94572" /translation="MMNKGGRLRKAVRKSIPATFRLFLAFNFFVYGLAKVVIGQFGEV TPEIEAAAGKGFTIAWTFFGYSHVYELFIGFGEILAAVLLLIPRTAALGAVIFMPIIV NIVLINYCFDIGVQDLSTILMVMCLILLWMDRRKFMGIFRQEPIDSRQVMKR*" /label="ywoB CDS" gene complement(3270953..3271417) /gene="ywoB" /locus_tag="BSU_36500" /old_locus_tag="BSU36500" /label="ywoB gene" promotor_-10 complement(3271447..3271466) /Source="Nicolas_upshift_promotors" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3271452) /Source="Nicolas_upshifts" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3271480..3271487) /Source="Nicolas_upshift_promotors" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3271618..3271621 /Source="Nicolas_upshift_promotors" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3271636..3271655 /Source="Nicolas_upshift_promotors" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3271640 /Source="Nicolas_upshifts" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="upshifts" CDS 3271699..3272913 /gene="amtB" /locus_tag="BSU_36510" /old_locus_tag="BSU36510" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14600241, 15849754, 16850406, 17001076, 21435182" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14600241, 15849754, 16850406, 17001076, 21435182; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ammonium transporter" /protein_id="NP_391532.1" /db_xref="EnsemblGenomes-Gn:BSU36510" /db_xref="EnsemblGenomes-Tr:CAB15668" /db_xref="GOA:Q07429" /db_xref="InterPro:IPR001905" /db_xref="InterPro:IPR018047" /db_xref="InterPro:IPR024041" /db_xref="InterPro:IPR029020" /db_xref="SubtiList:BG10869" /db_xref="UniProtKB/Swiss-Prot:Q07429" /translation="MQMGDTVFMFFCALLVWLMTPGLALFYGGMVKSKNVLSTAMHSF SSIAIVSIVWVLFGYTLAFAPGNSIIGGLEWAGLKGVGFDPGDYSDTIPHSLFMMFQM TFAVLTTAIISGAFAERMRFGAFLLFSVLWASLVYTPVAHWVWGGGWIGQLGALDFAG GNVVHISSGVAGLVLAIVLGKRKDGTASSPHNLIYTFLGGALIWFGWFGFNVGSALTL DGVAMYAFINTNTAAAAGIAGWILVEWIINKKPTMLGAVSGAIAGLVAITPAAGFVTP FASIIIGIIGGAVCFWGVFSLKKKFGYDDALDAFGLHGIGGTWGGIATGLFATTSVNS AGADGLFYGDASLIWKQIVAIAATYVFVFIVTFVIIKIVSLFLPLRATEEEESLGLDL TMHGEKAYQDSM*" /label="amtB CDS" gene 3271699..3272913 /gene="amtB" /locus_tag="BSU_36510" /old_locus_tag="BSU36510" /label="amtB gene" promotor_-10 complement(3272529..3272547) /Source="Nicolas_upshift_promotors" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3272530) /Source="Nicolas_upshifts" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3272561..3272568) /Source="Nicolas_upshift_promotors" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3272779..3272785 /Source="Nicolas_upshift_promotors" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3272799..3272818 /Source="Nicolas_upshift_promotors" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3272801 /Source="Nicolas_upshifts" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="upshifts" CDS 3272925..3273275 /gene="glnK" /locus_tag="BSU_36520" /old_locus_tag="BSU36520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14600241, 17001076, 21435182, 23461034, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14600241, 17001076, 21435182, 23461034, 25691471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nitrogen-regulated PII-like regulator protein" /protein_id="NP_391533.1" /db_xref="EnsemblGenomes-Gn:BSU36520" /db_xref="EnsemblGenomes-Tr:CAB15669" /db_xref="GOA:Q07428" /db_xref="InterPro:IPR002187" /db_xref="InterPro:IPR011322" /db_xref="InterPro:IPR015867" /db_xref="InterPro:IPR017918" /db_xref="PDB:4R25" /db_xref="PDB:4RX6" /db_xref="SubtiList:BG10870" /db_xref="UniProtKB/Swiss-Prot:Q07428" /translation="MSGQMFKVEIVTRPANFEKLKQELGKIGVTSLTFSNVHGCGLQK AHTELYRGVKIESNVYERLKIEIVVSKVPVDQVTETAKRVLKTGSPGDGKIFVYEISN TINIRTGEEGPEAL*" /label="glnK CDS" gene 3272925..3273275 /gene="glnK" /locus_tag="BSU_36520" /old_locus_tag="BSU36520" /label="glnK gene" downshifts 3273268 /Source="Nicolas_upshifts" /id="D1887" /incds=0 /nref=179 /ntot=251 /MaxReadThrough="2.13701" /MaxDrop="8.63831" /score="25.582072" /energy="-12.5" /TU="NA" /idTUdmin="U2860" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3273327..3273335 /Source="Nicolas_upshift_promotors" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3273349..3273357 /Source="Nicolas_upshift_promotors" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3273356 /Source="Nicolas_upshifts" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3273398..3273407 /Source="Nicolas_upshift_promotors" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3273420..3273435 /Source="Nicolas_upshift_promotors" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3273424 /Source="Nicolas_upshifts" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="upshifts" CDS 3273456..3274037 /gene="bcrC" /locus_tag="BSU_36530" /old_locus_tag="BSU36530" /EC_number="3.6.1.27" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12486040, 14612242, 15838020, 15849754, 15946938, 16850406, 27528508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486040, 14612242, 15838020, 15849754, 15946938, 16850406, 27528508; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl pyrophosphate phosphatase (bacitracin resistance)" /protein_id="NP_391534.1" /db_xref="EnsemblGenomes-Gn:BSU36530" /db_xref="EnsemblGenomes-Tr:CAB15670" /db_xref="GOA:P94571" /db_xref="InterPro:IPR000326" /db_xref="InterPro:IPR033879" /db_xref="InterPro:IPR036938" /db_xref="SubtiList:BG12488" /db_xref="UniProtKB/Swiss-Prot:P94571" /translation="MNYEIFKAIHGLSHHNSVLDSIMVFITEYAIVAYALILLAIWLF GNTQSRKHVLYAGITGIAGLVINYLITLVYFEPRPFVAHTVHTLIPHAADASFPSDHT TGALAISIAMLFRNRKIGWPLVIFGLLTGFSRIWVGHHYPVDVLGSLVVAIIIGFLFF RFSDLLRPFVDLVVRIYEAIINKLTKKPTDQNF*" /label="bcrC CDS" gene 3273456..3274037 /gene="bcrC" /locus_tag="BSU_36530" /old_locus_tag="BSU36530" /label="bcrC gene" promotor_-10 complement(3273554..3273573) /Source="Nicolas_upshift_promotors" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3273564) /Source="Nicolas_upshifts" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3273587..3273595) /Source="Nicolas_upshift_promotors" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3274018 /Source="Nicolas_upshifts" /id="D1888" /incds=0 /nref=192 /ntot=251 /MaxReadThrough="2.1929" /MaxDrop="6.53316" /score="25.582072" /energy="-12.5" /TU="NA" /idTUdmin="U2863" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(3274078..3274500) /gene="ywnJ" /locus_tag="BSU_36540" /old_locus_tag="BSU36540" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14762009, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391535.1" /db_xref="EnsemblGenomes-Gn:BSU36540" /db_xref="EnsemblGenomes-Tr:CAB15671" /db_xref="GOA:P71045" /db_xref="InterPro:IPR006976" /db_xref="SubtiList:BG12487" /db_xref="UniProtKB/Swiss-Prot:P71045" /translation="MNRLLLAGWIFFILLSVCTESFSGMVVSQTVAFHFQPHPDLSQF LVMDFTELTVPEAFIQKIGHAFSFFVLTYLLWKQRGSIRSAAAGSFAFAFFTEVLQLF FSRNGCIRDVLIDAVGIGLFYGLYVLAKRRKQEMYEKY*" /label="ywnJ CDS" gene complement(3274078..3274500) /gene="ywnJ" /locus_tag="BSU_36540" /old_locus_tag="BSU36540" /label="ywnJ gene" downshifts complement(3274097) /Source="Nicolas_upshifts" /id="D1889" /incds=0 /nref=9 /ntot=75 /MaxReadThrough="0.80227" /MaxDrop="3.65224" /score="4.98901321" /energy="-13.6" /TU="NA" /idTUdmin="U2869" /TUdmin=215 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3274535..3274550) /Source="Nicolas_upshift_promotors" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3274554) /Source="Nicolas_upshifts" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3274563..3274572) /Source="Nicolas_upshift_promotors" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3274611..3275462) /gene="spoIIQ" /locus_tag="BSU_36550" /old_locus_tag="BSU36550" /function="16.8: Protect" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16164552, 16959571, 17121846, 18077456, 21097616, 23859254, 26929302, 27381174, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164552, 16959571, 17121846, 18077456, 21097616, 23859254, 26929302, 27381174, 28784753; Product type f: factor" /codon_start=1 /transl_table=11 /product="forespore protein required for alternative engulfment" /protein_id="NP_391536.1" /db_xref="EnsemblGenomes-Gn:BSU36550" /db_xref="EnsemblGenomes-Tr:CAB15672" /db_xref="GOA:P71044" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="PDB:3TUF" /db_xref="PDB:3UZ0" /db_xref="SubtiList:BG11978" /db_xref="UniProtKB/Swiss-Prot:P71044" /translation="MREEEKKTSQVKKLQQFFRKRWVFPAIYLVSAAVILTAVLWYQS VSNDEVKDQLADNGGNSAYDNNDDAVEVGKSMENVAMPVVDSENVSVVKKFYETDAAK EEKEAALVTYNNTYSLSKGIDLAEKDGKDFDVSASLSGTVVKAEKDPVLGYVVEVEHA DGLSTVYQSLSEVSVEQGDKVKQNQVIGKSGKNLYSEDSGNHVHFEIRKDGVAMNPLN FMDKPVSSIEKAATQETEESIQQSSEKKDGSTEKGTEEKSGEKKDDSTDKSGSKESST TEDTEQS*" /label="spoIIQ CDS" gene complement(3274611..3275462) /gene="spoIIQ" /locus_tag="BSU_36550" /old_locus_tag="BSU36550" /label="spoIIQ gene" downshifts complement(3274620) /Source="Nicolas_upshifts" /id="D1890" /incds=0 /nref=19 /ntot=51 /MaxReadThrough="3.592" /MaxDrop="5.16472" /score="11.9597238" /energy="-7.1" /TU="U2869" /idTUdmin="U2866" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts complement(3274862) /Source="Nicolas_upshifts" /id="D1891" /incds=1 /nref=4 /ntot=59 /MaxReadThrough="6.6416" /MaxDrop="3.0034" /score="11.9597238" /energy="-7.1" /TU="U2869" /idTUdmin="U2866" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" promotor_-35 3275099..3275101 /Source="Nicolas_upshift_promotors" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3275118..3275137 /Source="Nicolas_upshift_promotors" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3275119..3275465 /Source="Nicolas_S_feature" /locus_tag="new_3760210_3760556" /HighExp="LBGstat, LBGtran, Cold, Sw, dia15, C30, G180, Lbexp, LBGexp, UNK1" /AntisenseName="spoIIQ" /AntisenseCor="-0.81767802234568998" /AntisenseRegPval="-65.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1406" upshifts 3275119 /Source="Nicolas_upshifts" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3275457..3275460 /Source="Nicolas_upshift_promotors" /id="U2868" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.27972027972028" /psig="0.121878121878122" /xcortree=579 /SigmaFactorBS="cgaaaaaactgctgaagttttttgacttgagaagttttcttt tcttcctcTCTCattgtttcatcacctcagcaacattctgaacacttttctgaaaata t" /listShort="S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 3275467..3275602 /Source="Nicolas_S_feature" /locus_tag="new_3760558_3760693" /HighExp="LBGstat, S8, LBGtran, Sw, LoTm, BC, Cold, S7, C30, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.122, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1407" upshifts 3275467 /Source="Nicolas_upshifts" /id="U2868" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.27972027972028" /psig="0.121878121878122" /xcortree=579 /SigmaFactorBS="cgaaaaaactgctgaagttttttgacttgagaagttttcttt tcttcctcTCTCattgtttcatcacctcagcaacattctgaacacttttctgaaaata t" /listShort="S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3275496) /Source="Nicolas_upshifts" /id="U2869" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=974 /SigmaFactorBS="tcagtctgtgcaaactacatctaaaaaagtttttttggatag gttGTATATATTTtcagaaaagtgttcagaatgttgctgaggtgatgaaacaatgaga g" /listShort="spoIIQ, ywnJ" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3275502..3275511) /Source="Nicolas_upshift_promotors" /id="U2869" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=974 /SigmaFactorBS="tcagtctgtgcaaactacatctaaaaaagtttttttggatag gttGTATATATTTtcagaaaagtgttcagaatgttgctgaggtgatgaaacaatgaga g" /listShort="spoIIQ, ywnJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3275603..3276094 /gene="ywnH" /locus_tag="BSU_36560" /old_locus_tag="BSU36560" /EC_number="2.3.1.183" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 16021622, 27694229; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminoacid analogs (phosphinothricin) N-acetyltransferase" /protein_id="NP_391537.1" /db_xref="EnsemblGenomes-Gn:BSU36560" /db_xref="EnsemblGenomes-Tr:CAB15673" /db_xref="GOA:P71043" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1VHS" /db_xref="SubtiList:BG12486" /db_xref="UniProtKB/Swiss-Prot:P71043" /translation="MTLRLAEHRDLEAVVAIYNSTIASRMVTADTEPVTPEDRMEWFS GHTESRPLYVAEDENGNVAAWISFETFYGRPAYNKTAEVSIYIDEACRGKGVGSYLLQ EALRIAPNLGIRSLMAFIFGHNKPSLKLFEKHGFAEWGLFPGIAEMDGKRYDLKILGR ELS*" /label="ywnH CDS" gene 3275603..3276094 /gene="ywnH" /locus_tag="BSU_36560" /old_locus_tag="BSU36560" /label="ywnH gene" promotor_-35 3275832..3275837 /Source="Nicolas_upshift_promotors" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3275853..3275871 /Source="Nicolas_upshift_promotors" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3275864 /Source="Nicolas_upshifts" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3275955..3276863) /Source="Nicolas_S_feature" /locus_tag="new_3761046_3761954_c" /HighExp="H2O2, dia15, Diami, dia5, S8, Paraq, G180, G135, C30, G150" /AntisenseName="ywnG" /AntisenseCor="0.27407310266030799" /AntisenseRegPval="-5.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S1408" CDS 3276091..3276609 /gene="ywnG" /locus_tag="BSU_36570" /old_locus_tag="BSU36570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391538.1" /db_xref="EnsemblGenomes-Gn:BSU36570" /db_xref="EnsemblGenomes-Tr:CAB15674" /db_xref="GOA:P71042" /db_xref="InterPro:IPR035287" /db_xref="SubtiList:BG12485" /db_xref="UniProtKB/Swiss-Prot:P71042" /translation="MISLDKDENEIEHHNEENSLVEQETAPVGQESRQLSASAVKSLS DIAKWGKISGILLIIMGSLVTLSVLMTVIGAIPGVLLIISGVFLMRSAKAAAEAEGNL TGSAGESMLENYGTFIKMQLFYAASSIVTVLIGIIVAIFVLVVIGIAAFENTPSYDDP DSYYYEDDPVFE*" /label="ywnG CDS" gene 3276091..3276609 /gene="ywnG" /locus_tag="BSU_36570" /old_locus_tag="BSU36570" /label="ywnG gene" downshifts 3276414 /Source="Nicolas_upshifts" /id="D1892" /incds=1 /nref=1 /ntot=29 /MaxReadThrough="4.194" /MaxDrop="1.82458" /score="-3.39058903" /energy="-13.3" /TU="U2867,U2868,U2870" /idTUdmin="U2868" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 3276612 /Source="Nicolas_upshifts" /id="D1893" /incds=0 /nref=3 /ntot=133 /MaxReadThrough="2.87136" /MaxDrop="2.9486" /score="-3.39058903" /energy="-13.3" /TU="U2867" /idTUdmin="U2870" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3276768..3276899 /locus_tag="BSU_36575" /old_locus_tag="BSU36575" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514007.1" /translation="MNIKKTDEVGINPKPHFLFRVSACKKTHPDRLENLNNPGADLL* " /label="hypothetical protein CDS" gene 3276768..3276899 /locus_tag="BSU_36575" /old_locus_tag="BSU36575" /label="gene" CDS complement(3276896..3277330) /gene="ywnF" /locus_tag="BSU_36580" /old_locus_tag="BSU36580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391539.1" /db_xref="EnsemblGenomes-Gn:BSU36580" /db_xref="EnsemblGenomes-Tr:CAB15675" /db_xref="GOA:P71041" /db_xref="InterPro:IPR020205" /db_xref="SubtiList:BG12484" /db_xref="UniProtKB/Swiss-Prot:P71041" /translation="MNFYRVEQMPGFIKTEMQKIQKAVQPFMKKTVIYRFLAIPLAAF SLFNLAAFLFHASADRESLISAGIFALLAALGLAFFKEAGYQHKQIQKTVHIYMLNRI KKSEILSEERKSSYARQIKEEPFAMRSFVEFLTEEDRRKKMY*" /label="ywnF CDS" gene complement(3276896..3277330) /gene="ywnF" /locus_tag="BSU_36580" /old_locus_tag="BSU36580" /label="ywnF gene" downshifts complement(3276908) /Source="Nicolas_upshifts" /id="D1894" /incds=0 /nref=174 /ntot=254 /MaxReadThrough="4.22489" /MaxDrop="5.35802" /score="21.5198482" /energy="-21.3" /TU="U2871" /idTUdmin="U2873" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3277379..3277398) /Source="Nicolas_upshift_promotors" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3277386) /Source="Nicolas_upshifts" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3277388..3277685) /Source="Nicolas_S_feature" /locus_tag="new_3762479_3762776_c" /HighExp="Etha, S6, S3, S4, S8, S5, S7, M9-stat, Sw, Salt" /AntisenseName="clsA" /AntisenseCor="-0.16109419145114601" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigEF" /TUshortPSig="0.99, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1409" promotor_-35 complement(3277413..3277420) /Source="Nicolas_upshift_promotors" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3277459..3277463 /Source="Nicolas_upshift_promotors" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3277480..3277499 /Source="Nicolas_upshift_promotors" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3277492..3277572 /Source="Nicolas_S_feature" /locus_tag="new_3762583_3762663" /HighExp="LBGstat, Diami, dia15, G180, Oxctl, H2O2, T0.30H, S8, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1410" upshifts 3277493 /Source="Nicolas_upshifts" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="upshifts" CDS 3277573..3279021 /gene="clsA" /locus_tag="BSU_36590" /old_locus_tag="BSU36590" /EC_number="2.7.8.-" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14973018, 16755131, 18820022, 26708983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973018, 16755131, 18820022, 26708983; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cardiolipin synthase (major)" /protein_id="NP_391540.1" /db_xref="EnsemblGenomes-Gn:BSU36590" /db_xref="EnsemblGenomes-Tr:CAB15676" /db_xref="GOA:P71040" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="InterPro:IPR027379" /db_xref="InterPro:IPR030874" /db_xref="SubtiList:BG12483" /db_xref="UniProtKB/Swiss-Prot:P71040" /translation="MSISSILLSLFFILNILLAIIVIFKERRDASASWAWLLVLFFIP VLGFILYLLFGHNLRRKHLFQWEDRKKIGIERLLKHQLEDLETKQFQFNNRATFDNKD LIYMLIMNNHAVFTEDNSVDVITDGRDKFQRLLSDISKAKDHIHLQYYIYKGDELGKK LRDALIQKAKEGVQVRVLYDELGSRTLRKKFFKELREAGGHVEVFFPSKLRPINLRLN YRNHRKLVIIDGMTGYVGGFNVGDEYLGLNPKFGYWRDTHIRLQGTAVHAIQTRFILD WNQASHHHTLTYIPNHFPDYGPKGNVGMQIVTSGPDSEWEQIKNGYIKMISNAKRSIL IQTPYFIPDASLLDALRIACLSGIDVNIMIPNKPDHAFVYWATLSYIGDLLKAGATVY IYDNGFIHAKTIVVDDEIASVGTANIDVRSFRLNFEVNAFIYDITIAKKLVSTFKEDL LVSRKFTYEEYLQRPLWIRIKESVSRLLSPIL*" /label="clsA CDS" gene 3277573..3279021 /gene="clsA" /locus_tag="BSU_36590" /old_locus_tag="BSU36590" /label="clsA gene" upshifts complement(3277685) /Source="Nicolas_upshifts" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3277686..3277704) /Source="Nicolas_upshift_promotors" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature complement(3277687..3278030) /Source="Nicolas_S_feature" /locus_tag="new_3762778_3763121_c" /HighExp="S6, S8, S4, S5, S7, S3, T5.0H, M9-stat, C30, T4.0H" /AntisenseName="clsA" /AntisenseCor="3.3648966966722899E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1411" promotor_-35 complement(3277720..3277726) /Source="Nicolas_upshift_promotors" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3278008..3278026) /Source="Nicolas_upshift_promotors" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3278030) /Source="Nicolas_upshifts" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3278042..3278047) /Source="Nicolas_upshift_promotors" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3279010 /Source="Nicolas_upshifts" /id="D1895" /incds=0 /nref=6 /ntot=214 /MaxReadThrough="0.7051" /MaxDrop="4.44298" /score="26.7449315" /energy="-19.5" /TU="NA" /idTUdmin="U2872" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3279042..3279815) /gene="mta" /locus_tag="BSU_36600" /old_locus_tag="BSU36600" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10200972, 11581256, 18502870" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10200972, 11581256, 18502870; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator regulating efflux transporters synthesis (Fur-independent bacillibactin export)" /protein_id="NP_391541.1" /db_xref="EnsemblGenomes-Gn:BSU36600" /db_xref="EnsemblGenomes-Tr:CAB15677" /db_xref="GOA:P71039" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR012925" /db_xref="InterPro:IPR036244" /db_xref="PDB:1JBG" /db_xref="PDB:1R8D" /db_xref="SubtiList:BG12482" /db_xref="UniProtKB/Swiss-Prot:P71039" /translation="MKYQVKQVAEISGVSIRTLHHYDNIELLNPSALTDAGYRLYSDA DLERLQQILFFKEIGFRLDEIKEMLDHPNFDRKAALQSQKEILMKKKQRMDEMIQTID RTLLSVDGGETMNKRDLFAGLSMKDIEEHQQTYADEVRKLYGKEIAEETEKRTSAYSA DDWRTIMAEFDSIYRRIAARMKHGPDDAEIQAAVGAFRDHICQYHYDCTLDIFRGLGE VYITDERFTDSINQYGEGLAAFLREAIIIYCDHQENPRP*" /label="mta CDS" gene complement(3279042..3279815) /gene="mta" /locus_tag="BSU_36600" /old_locus_tag="BSU36600" /label="mta gene" downshifts complement(3279064) /Source="Nicolas_upshifts" /id="D1896" /incds=0 /nref=1 /ntot=54 /MaxReadThrough="0.46006" /MaxDrop="2.97389" /score="11.4339746" /energy="-19.5" /TU="NA" /idTUdmin="U2876" /TUdmin=1342 /isTUend="FALSE" /label="downshifts" promotor_-35 3279890..3279893 /Source="Nicolas_upshift_promotors" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3279909..3279928 /Source="Nicolas_upshift_promotors" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3279913 /Source="Nicolas_upshifts" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="upshifts" CDS 3279960..3280343 /gene="ywnC" /locus_tag="BSU_36610" /old_locus_tag="BSU36610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391542.1" /db_xref="EnsemblGenomes-Gn:BSU36610" /db_xref="EnsemblGenomes-Tr:CAB15678" /db_xref="GOA:P71038" /db_xref="InterPro:IPR035287" /db_xref="SubtiList:BG12481" /db_xref="UniProtKB/Swiss-Prot:P71038" /translation="MNPETMNKTLISISKWGKATGILFIIMGAITALSGAFFFLIGAV PGVLQIISGIFLMRSAREAGQMAEHNSGQSEDLMLENYAKFVKMQGIYLIVSIAVSIL AIIAFFIFLMLGIADGLFSDTYSTY*" /label="ywnC CDS" gene 3279960..3280343 /gene="ywnC" /locus_tag="BSU_36610" /old_locus_tag="BSU36610" /label="ywnC gene" downshifts 3280330 /Source="Nicolas_upshifts" /id="D1897" /incds=0 /nref=60 /ntot=180 /MaxReadThrough="1.0319" /MaxDrop="4.45212" /score="35.5991488" /energy="-11.4" /TU="NA" /idTUdmin="U2875" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3280378..3281019) /gene="ywnB" /locus_tag="BSU_36620" /old_locus_tag="BSU36620" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391543.1" /db_xref="EnsemblGenomes-Gn:BSU36620" /db_xref="EnsemblGenomes-Tr:CAB15679" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12480" /db_xref="UniProtKB/Swiss-Prot:P71037" /translation="MKIGIIGASGKAGNEILKEAKKRGHEVTAIVRNASKVQEQDVAI LEKDVFELTAEDIKPFDAVVNAFGAAPGQEHLHVEAGRALISILKDAKHTRLLVVGGA GSLFVDEAKTTRLMDTPEFPKEYLPTASNQGENLKDLQQTDSISWTFLSPAAFFDPAG KRTGSYQKGKDNVIVNAKGDSYISYADYAIAVLDELEHPEHKNERFTVVSEAE*" /label="ywnB CDS" gene complement(3280378..3281019) /gene="ywnB" /locus_tag="BSU_36620" /old_locus_tag="BSU36620" /label="ywnB gene" downshifts complement(3280428) /Source="Nicolas_upshifts" /id="D1898" /incds=0 /nref=20 /ntot=170 /MaxReadThrough="3.62026" /MaxDrop="4.98934" /score="21.1363072" /energy="-11.4" /TU="U2876" /idTUdmin="U2876" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(3281087..3281488) /gene="ywnA" /locus_tag="BSU_36630" /old_locus_tag="BSU36630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391544.1" /db_xref="EnsemblGenomes-Gn:BSU36630" /db_xref="EnsemblGenomes-Tr:CAB15680" /db_xref="GOA:P71036" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1XD7" /db_xref="SubtiList:BG12479" /db_xref="UniProtKB/Swiss-Prot:P71036" /translation="MINSRLAVAIHILSLISMDEKTSSEIIADSVNTNPVVVRRMISL LKKADILTSRAGVPGASLKKDPADISLLEVYRAVQKQEELFAVHENPNPKCPVGKKIQ NALDETFESVQRAMENELASKSLKDVMNHLF*" /label="ywnA CDS" gene complement(3281087..3281488) /gene="ywnA" /locus_tag="BSU_36630" /old_locus_tag="BSU36630" /label="ywnA gene" promotor_-10 complement(3281537..3281556) /Source="Nicolas_upshift_promotors" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3281547) /Source="Nicolas_upshifts" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3281549..3281622) /Source="Nicolas_S_feature" /locus_tag="new_3766640_3766713_c" /HighExp="BT, Etha, S1, B60, LoTm, B36, S2, Glucon, Sw, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.18507799999999999" /TUshortSig="Sig-" /TUshortPSig="0.106" /TUlongSig="SigH, SigA, SigB, SigB" /TUlongPSig="1, 0.993, 1, 0.995" /label="S1412" promotor_-35 complement(3281571..3281576) /Source="Nicolas_upshift_promotors" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3281623..3283332) /gene="ureC" /locus_tag="BSU_36640" /old_locus_tag="BSU36640" /EC_number="3.5.1.5" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (alpha subunit)" /protein_id="NP_391545.1" /db_xref="EnsemblGenomes-Gn:BSU36640" /db_xref="EnsemblGenomes-Tr:CAB15681" /db_xref="GOA:P77837" /db_xref="InterPro:IPR005848" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR011612" /db_xref="InterPro:IPR017950" /db_xref="InterPro:IPR017951" /db_xref="InterPro:IPR029754" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG11983" /db_xref="UniProtKB/Swiss-Prot:P77837" /translation="MKMSREEYAELFGPTTGDKIRLGDTDLWIEVEKDFTVYGEEMIF GGGKTIRDGMGQNGRITGKDGALDLVITNVVLLDYTGIVKADVGVKDGRIVGVGKSGN PDIMDGVDPHMVIGAGTEVISGEGKILTAGGVDTHIHFICPQQMEVALSSGVTTLLGG GTGPATGSKATTCTSGAWYMARMLEAAEEFPINVGFLGKGNASDKAPLIEQVEAGAIG LKLHEDWGTTPSAIKTCMEVVDEADIQVAIHTDTINEAGFLENTLDAIGDRVIHTYHI EGAGGGHAPDIMKLASYANILPSSTTPTIPYTVNTMDEHLDMMMVCHHLDAKVPEDVA FSHSRIRAATIAAEDILHDIGAISMTSSDSQAMGRVGEVIIRTWQVADKMKKQRGALA GENGNDNVRAKRYIAKYTINPAITHGLSHEVGSVEKGKLADLVLWDPVFFGVKPELVL KGGMIARAQMGDPNASIPTPEPVFMRQMYASYGKANRSTSITFMSQASIERGVAESLG LEKRISPVKNIRKLSKLDMKLNSALPKIEIDPKTYQVFADGEELSCQPVDYVPLGQRY FLF*" /label="ureC CDS" gene complement(3281623..3283332) /gene="ureC" /locus_tag="BSU_36640" /old_locus_tag="BSU36640" /label="ureC gene" CDS complement(3283329..3283703) /gene="ureB" /locus_tag="BSU_36650" /old_locus_tag="BSU36650" /EC_number="3.5.1.5" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (beta subunit)" /protein_id="NP_391546.1" /db_xref="EnsemblGenomes-Gn:BSU36650" /db_xref="EnsemblGenomes-Tr:CAB15682" /db_xref="GOA:P71035" /db_xref="InterPro:IPR002019" /db_xref="InterPro:IPR036461" /db_xref="SubtiList:BG11982" /db_xref="UniProtKB/Swiss-Prot:P71035" /translation="MKPGAFQIAEGTITINEGREIREVTVKNTGSRSIQVGSHFHFAE ANGALLFDRELAIGMRLDVPSGTSVRFEPGEQKTVSLVEIRGRKTIRGLNGMADTFID ERGKEKTLANLKQAGWMEGVIR*" /label="ureB CDS" gene complement(3283329..3283703) /gene="ureB" /locus_tag="BSU_36650" /old_locus_tag="BSU36650" /label="ureB gene" CDS complement(3283700..3284017) /gene="ureA" /locus_tag="BSU_36660" /old_locus_tag="BSU36660" /EC_number="3.5.1.5" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (gamma subunit)" /protein_id="NP_391547.1" /db_xref="EnsemblGenomes-Gn:BSU36660" /db_xref="EnsemblGenomes-Tr:CAB15683" /db_xref="GOA:P75030" /db_xref="InterPro:IPR002026" /db_xref="InterPro:IPR012010" /db_xref="InterPro:IPR036463" /db_xref="SubtiList:BG11981" /db_xref="UniProtKB/Swiss-Prot:P75030" /translation="MKLTPVEQEKLLIFAAGELAKQRKARGVLLNYPEAAAYITCFIM EGARDGKGVAELMEAGRHVLTEKDVMEGVPEMLDSIQVEATFPDGVKLVTVHQPISAE VKS*" /label="ureA CDS" gene complement(3283700..3284017) /gene="ureA" /locus_tag="BSU_36660" /old_locus_tag="BSU36660" /label="ureA gene" S_feature complement(3284018..3284102) /Source="Nicolas_S_feature" /locus_tag="new_3769109_3769193_c" /HighExp="BT, B60, B36, S1, Etha, LoTm, M9-stat, S2, T0.30H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigH, SigB" /TUshortPSig="0.106, 1, 1" /TUlongSig="SigA, SigB" /TUlongPSig="0.993, 0.995" /label="S1413" upshifts complement(3284102) /Source="Nicolas_upshifts" /id="U2877" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.525474525474525" /psig="0.105894105894106" /xcortree=402 /SigmaFactorBS="gatgaagaaacggcatgccgctttgaaaggcatcttaccgta tgaCCCCCATTCTCGAAgaaagggaggtgatgtcccgcctgactgttccgcaaattcg t" /listShort="S1413, ureA, ureB, ureC, S1412, ywnA" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3284104..3284117) /Source="Nicolas_upshift_promotors" /id="U2877" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.525474525474525" /psig="0.105894105894106" /xcortree=402 /SigmaFactorBS="gatgaagaaacggcatgccgctttgaaaggcatcttaccgta tgaCCCCCATTCTCGAAgaaagggaggtgatgtcccgcctgactgttccgcaaattcg t" /listShort="S1413, ureA, ureB, ureC, S1412, ywnA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature complement(3284104..3284197) /Source="Nicolas_S_feature" /locus_tag="new_3769195_3769288_c" /HighExp="BT, Etha, B60, S1, B36, BC, S2, LoTm, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.30781199999999997" /TUshortSig="SigH, SigB" /TUshortPSig="1, 1" /TUlongSig="SigA, SigB" /TUlongPSig="0.993, 0.995" /label="S1414" CDS complement(3284198..3284362) /gene="ywzE" /locus_tag="BSU_36668" /old_locus_tag="BSU36668" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (putative phage interference protein)" /protein_id="YP_009514008.1" /translation="MVNLKNILLNKQLEGIQILIVELVRQVIIEISRKKDICYLSRAQ SGKRVNLIFP*" /label="ywzE CDS" gene complement(3284198..3284362) /gene="ywzE" /locus_tag="BSU_36668" /old_locus_tag="BSU36668" /label="ywzE gene" promotor_-10 complement(3284285..3284303) /Source="Nicolas_upshift_promotors" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="promotor_-10" upshifts complement(3284297) /Source="Nicolas_upshifts" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="upshifts" promotor_-35 complement(3284315..3284323) /Source="Nicolas_upshift_promotors" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="promotor_-35" S_feature complement(3284363..3284534) /Source="Nicolas_S_feature" /locus_tag="new_3769454_3769625_c" /HighExp="Etha, BT, S1, GM-0.2, GM-0.1, Salt, GM 5, T-5.40H, MG 60, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1415" CDS complement(3284535..3284717) /gene="ywzF" /locus_tag="BSU_36669" /old_locus_tag="BSU36669" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /db_xref="PSEUDO:CAX52705.1" /translation="MKAGILHSLRGTVAISEVTVHDAELMAIVGFSVSWRSAPQTGLH AMLPVAEQNNGLPSGM*" /label="ywzF CDS" gene complement(3284535..3284717) /gene="ywzF" /locus_tag="BSU_36669" /old_locus_tag="BSU36669" /pseudo /label="ywzF gene" S_feature complement(3284718..3284864) /Source="Nicolas_S_feature" /locus_tag="new_3769809_3769955_c" /HighExp="Etha, BT, S1, Salt, GM-0.2, GM-0.1, M9-stat, GM 5, GM 45, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15897800000000001" /TUshortSig="SigA, SigB" /TUshortPSig="0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1416" promotor_-10 complement(3284852..3284871) /Source="Nicolas_upshift_promotors" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3284864) /Source="Nicolas_upshifts" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="upshifts" S_feature complement(3284866..3284980) /Source="Nicolas_S_feature" /locus_tag="new_3769957_3770070_c" /HighExp="Etha, Salt, M9-stat, S8, B60, B36, Sw, Gly, LoTm, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1417" promotor_-35 complement(3284886..3284893) /Source="Nicolas_upshift_promotors" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-35" Polymorphism join(3284967,3284969) /Source="geneious" /ID="SNP_BsDelta6_3770059_3770058" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(A)8 -> (A)9" /Codon_Change /Coverage=64 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="A" /Variant_P_Value="2.1e-197" /Variant_Raw_Frequency=61 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" upshifts 3284994 /Source="Nicolas_upshifts" /id="U2880" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.702297702297702" /psig="0.010989010989011" /xcortree=123 /SigmaFactorBS="tttttttgttatatttattcacatcagaaaaagcgaaaaaaa agacaagaaacatttcgtttcCTGCCtcttccgtacgattaatctttatctgaaaatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3284997..3285001 /Source="Nicolas_upshift_promotors" /id="U2880" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.702297702297702" /psig="0.010989010989011" /xcortree=123 /SigmaFactorBS="tttttttgttatatttattcacatcagaaaaagcgaaaaaaa agacaagaaacatttcgtttcCTGCCtcttccgtacgattaatctttatctgaaaatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3285014..3285202) /gene="csbD" /locus_tag="BSU_36670" /old_locus_tag="BSU36670" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10376822, 11988534" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10376822, 11988534; Product type f: factor" /codon_start=1 /transl_table=11 /product="stress response protein" /protein_id="NP_391548.1" /db_xref="EnsemblGenomes-Gn:BSU36670" /db_xref="EnsemblGenomes-Tr:CAB15684" /db_xref="InterPro:IPR008462" /db_xref="InterPro:IPR036629" /db_xref="SubtiList:BG12478" /db_xref="UniProtKB/Swiss-Prot:P70964" /translation="MGNDSVKDKMKGGFNKAKGEVKDKVGDMADRTDMQAEGKKDKAK GEIQKDIGKAKDKFSDKD*" /label="csbD CDS" gene complement(3285014..3285202) /gene="csbD" /locus_tag="BSU_36670" /old_locus_tag="BSU36670" /label="csbD gene" downshifts complement(3285025) /Source="Nicolas_upshifts" /id="D1899" /incds=0 /nref=69 /ntot=139 /MaxReadThrough="6.39376" /MaxDrop="6.75256" /score="21.8463823" /energy="-10.2" /TU="U2881" /idTUdmin="U2882" /TUdmin=221 /isTUend="FALSE" /label="downshifts" downshifts 3285192 /Source="Nicolas_upshifts" /id="D1900" /incds=0 /nref=15 /ntot=36 /MaxReadThrough="0.59322" /MaxDrop="5.27268" /score="-5.47050177" /energy="-8.1" /TU="NA" /idTUdmin="U2880" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3285228..3285246) /Source="Nicolas_upshift_promotors" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3285239) /Source="Nicolas_upshifts" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="upshifts" promotor_-35 complement(3285260..3285266) /Source="Nicolas_upshift_promotors" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="promotor_-35" CDS complement(3285275..3285775) /gene="ywmF" /locus_tag="BSU_36680" /old_locus_tag="BSU36680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391549.2" /db_xref="EnsemblGenomes-Gn:BSU36680" /db_xref="EnsemblGenomes-Tr:CAB15685" /db_xref="GOA:P70963" /db_xref="SubtiList:BG12477" /db_xref="UniProtKB/Swiss-Prot:P70963" /translation="MHVRGNSMFGFNDMVKFLWSFLIVLPLVQIIHVSGHSFMAFIFG GKGSLDIGMGKTLLKIGPIRFRTIYFIDSFCRYGELKIDNRFSNALVYAGGCLFNLIT IFAINLLIIHSVLKPNVFFYQFVYFSTYYVFFALLPVRYSEKKSSDGLAIYKVLRYGE RYEIDK*" /label="ywmF CDS" gene complement(3285275..3285775) /gene="ywmF" /locus_tag="BSU_36680" /old_locus_tag="BSU36680" /label="ywmF gene" promotor_-10 complement(3285811..3285830) /Source="Nicolas_upshift_promotors" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3285818) /Source="Nicolas_upshifts" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="upshifts" promotor_-35 complement(3285844..3285850) /Source="Nicolas_upshift_promotors" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-35" CDS complement(3285910..3287043) /gene="rapB" /locus_tag="BSU_36690" /old_locus_tag="BSU36690" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9843420, 10629174, 12875849, 19332814, 19684115" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9843420, 10629174, 12875849, 19332814, 19684115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391550.1" /db_xref="EnsemblGenomes-Gn:BSU36690" /db_xref="EnsemblGenomes-Tr:CAB15686" /db_xref="GOA:P70962" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11965" /db_xref="UniProtKB/Swiss-Prot:P70962" /translation="MAAYEIPSSQVGVKINKWYKHILAFQVADAVKLKEEIDLDIEQM EEDQLLLLYYQLISYRHQIMLDYVKPDLHEESQLQYRELIKTLESNQDSISGLSEYYF HLFRGMYEFEQNNYISAISFYRKAEKMLAFVEDEIERAEFHFKVAEVFYIMKQTHFSM NHAVQALETYKAHDFYRVRRIQCHFVISGNYIDYRNYEKALEHLDDAYRLALLEGQPR LIGSALYNIGNCYDDKGELDQAAEYFEKALPVFEDYQLEQLPKALFSLTRVLFKKQDS EAAIRYYEKGIAIAQKRNDFFSLAKYKFLQALYVESVNLNMIQEVFDYMEEKGLYVYI EEFALDAASYFSHREQYKEAVYFYEKAVSMREMIQRNDCLYEV*" /label="rapB CDS" gene complement(3285910..3287043) /gene="rapB" /locus_tag="BSU_36690" /old_locus_tag="BSU36690" /label="rapB gene" downshifts complement(3285928) /Source="Nicolas_upshifts" /id="D1901" /incds=0 /nref=244 /ntot=265 /MaxReadThrough="2.8683" /MaxDrop="6.81344" /score="30.5146793" /energy="-8.1" /TU="NA" /idTUdmin="U2883" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(3287070..3287089) /Source="Nicolas_upshift_promotors" /id="U2883" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2953 /SigmaFactorBS="cataaagaaggaatcattgtaagaaaatttaattccaaagcc atacatTATGATAAAATATAACCAATtagaaaatagaaagggttggaggggcatggcc g" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3287077) /Source="Nicolas_upshifts" /id="U2883" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2953 /SigmaFactorBS="cataaagaaggaatcattgtaagaaaatttaattccaaagcc atacatTATGATAAAATATAACCAATtagaaaatagaaagggttggaggggcatggcc g" /listShort="rapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3287140..3287158) /Source="Nicolas_upshift_promotors" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3287156) /Source="Nicolas_upshifts" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3287172..3287179) /Source="Nicolas_upshift_promotors" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3287235..3288260) /gene="moaA" /locus_tag="BSU_36700" /old_locus_tag="BSU36700" /EC_number="4.1.99.22" /function="16.10: Respire" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2170340, 7860592, 16632608, 19566093, 23286307, 25896388, 25941396, 26575208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP 3',8-cyclase" /protein_id="NP_391551.1" /db_xref="EnsemblGenomes-Gn:BSU36700" /db_xref="EnsemblGenomes-Tr:CAB15687" /db_xref="GOA:P39757" /db_xref="InterPro:IPR000385" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010505" /db_xref="InterPro:IPR013483" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR034395" /db_xref="InterPro:IPR034481" /db_xref="SubtiList:BG10980" /db_xref="UniProtKB/Swiss-Prot:P39757" /translation="MITESRQMLDKRNRPLRDLRISVTDRCNFRCTYCMPAELFGPDY PFLKKEELLSFEELERLATLFVTRFGVEKIRLTGGEPLMRKDMPELIKKLARIPGIRD IAMTTNGSLLPVYAKRLKEAGLKRVTISLDSLEDERFKKINGRGVSVSKVLEGIEAAK QAGLGVKINMVVQKGVNEKDILPMARYFKEKGHILRFIEFMDVGNTNQWEKKDVMTKA EIIDLINKHMPVEPIAPNYIGEVASRFRYLDGSGEIGVISSVSDAFCGSCNRARLSAR GELFTCLFASSGFDLRAPVRQELSDDELSEMIGTVWKNRIDQYSVDRTLSKASGKKKV EMSYIGG*" /label="moaA CDS" gene complement(3287235..3288260) /gene="moaA" /locus_tag="BSU_36700" /old_locus_tag="BSU36700" /label="moaA gene" downshifts complement(3287248) /Source="Nicolas_upshifts" /id="D1902" /incds=0 /nref=23 /ntot=147 /MaxReadThrough="3.05546" /MaxDrop="3.66108" /score="13.625744" /energy="-10.8" /TU="NA" /idTUdmin="U2885" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3288276..3289064) /gene="fdhD" /locus_tag="BSU_36710" /old_locus_tag="BSU36710" /function="16.11: Scavenge (Catabolism)" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2170340, 7860592, 19114526, 20011599, 22194618; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein sulfur transferase involved in molybdenum cofactor synthesis" /protein_id="NP_391552.1" /db_xref="EnsemblGenomes-Gn:BSU36710" /db_xref="EnsemblGenomes-Tr:CAB15688" /db_xref="GOA:P39756" /db_xref="InterPro:IPR003786" /db_xref="InterPro:IPR016193" /db_xref="SubtiList:BG10979" /db_xref="UniProtKB/Swiss-Prot:P39756" /translation="MNDKVTAVRDVWRYEQGEISKVEDRMVTEFPLTVILNGSEFVTL VCTPEHIEELVIGFLASEGVIRFQKEIKRFTIDESLGFVYVDLVHPETLDQKDYTKRV IGSCCGKGRHFYFQQDVKTAKTAVSQIKISPEACLALMKDMQQGSGTFQDTGGVHNAA LCDTEKLLLMRTDIGRHNALDKLYGHCLLNGMSVRDKLIVFSGRISSEVLLKAAKIGV SIVISKSAPTELAIQMAEELNITAIGFVRNGSFNVYTHPERIRE*" /label="fdhD CDS" gene complement(3288276..3289064) /gene="fdhD" /locus_tag="BSU_36710" /old_locus_tag="BSU36710" /label="fdhD gene" promotor_-10 complement(3289090..3289109) /Source="Nicolas_upshift_promotors" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3289096) /Source="Nicolas_upshifts" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3289098..3289309) /Source="Nicolas_S_feature" /locus_tag="new_3774188_3774399_c" /HighExp="Etha, Sw, Salt, Heat, S8, Gly, S6, S7, BC, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.16930300000000001" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1418" promotor_-35 complement(3289123..3289130) /Source="Nicolas_upshift_promotors" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3289310..3289471) /gene="ywmE" /locus_tag="BSU_36720" /old_locus_tag="BSU36720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391553.1" /db_xref="EnsemblGenomes-Gn:BSU36720" /db_xref="EnsemblGenomes-Tr:CAB15689" /db_xref="GOA:P70966" /db_xref="SubtiList:BG12476" /db_xref="UniProtKB/Swiss-Prot:P70966" /translation="MKLFGMIFLIATVAFILLGVLLKLAAFFFVSILTLIAAIVLFTV LKKNQHNQT*" /label="ywmE CDS" gene complement(3289310..3289471) /gene="ywmE" /locus_tag="BSU_36720" /old_locus_tag="BSU36720" /label="ywmE gene" promotor_-10 complement(3289484..3289502) /Source="Nicolas_upshift_promotors" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="promotor_-10" upshifts complement(3289504) /Source="Nicolas_upshifts" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="upshifts" promotor_-35 complement(3289516..3289522) /Source="Nicolas_upshift_promotors" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="promotor_-35" CDS complement(3289565..3290239) /gene="ywmD" /locus_tag="BSU_36730" /old_locus_tag="BSU36730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_391554.1" /db_xref="EnsemblGenomes-Gn:BSU36730" /db_xref="EnsemblGenomes-Tr:CAB15690" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12475" /db_xref="UniProtKB/Swiss-Prot:P70961" /translation="MKKLLAAGIIGLLTVSIASPSFAAEKQADTNVAVLFDGSGSMVQ KTGGERKIDIAKKSVKSFAELLPKDTNLMLRVFGHAGNNKLSGKALSCSTTETIYGLH PYEGSLFDNSLSELKPTGWTPIAKALADTRKEFEAFDADGKNVVYLITDGEETCGGDP AAEIEKLRASNVDTIVNIIGFNFDVKGNEEMKQAAVAGGGEYISANSADEFEQAWEKE AQKFTE*" /label="ywmD CDS" gene complement(3289565..3290239) /gene="ywmD" /locus_tag="BSU_36730" /old_locus_tag="BSU36730" /label="ywmD gene" downshifts complement(3289580) /Source="Nicolas_upshifts" /id="D1903" /incds=0 /nref=16 /ntot=88 /MaxReadThrough="0.76221" /MaxDrop="4.19611" /score="25.2461653" /energy="-9.6" /TU="NA" /idTUdmin="U2886" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS complement(3290292..3290432) /locus_tag="BSU_36739" /old_locus_tag="BSU36739" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514009.1" /translation="MITQAVYAFWAEMAKNERHFKRFWTDRESSTKGSMSYIFLHFRI LA*" /label="hypothetical protein CDS" gene complement(3290292..3290432) /locus_tag="BSU_36739" /old_locus_tag="BSU36739" /label="gene" CDS complement(3290563..3291246) /gene="ywmC" /locus_tag="BSU_36740" /old_locus_tag="BSU36740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_391555.1" /db_xref="EnsemblGenomes-Gn:BSU36740" /db_xref="EnsemblGenomes-Tr:CAB15691" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12474" /db_xref="UniProtKB/Swiss-Prot:P70960" /translation="MKKRFSLIMMTGLLFGLTSPAFAAEKTETEAKAPANVAVLLDAS GSMAKRIDGVSKFNSAKKEISKFASSLPEGTQVKMSVFGSEGNNKNSGKVQSCEAIRN VYGFQSFNEQSFLNSLNTIGPTGWTPIAKALNEAKSSFDQLDAKGEKVVYLLTDGEET CGGNPIKTAKELQKDNITVNVIGFDYKEGYKGQLNAIAKVGGGEYFPAYTQKDVEKIF TQQSLMLSK*" /label="ywmC CDS" gene complement(3290563..3291246) /gene="ywmC" /locus_tag="BSU_36740" /old_locus_tag="BSU36740" /label="ywmC gene" promotor_-35 3291623..3291627 /Source="Nicolas_upshift_promotors" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3291632..3292663) /gene="spoIID" /locus_tag="BSU_36750" /old_locus_tag="BSU36750" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15752199, 16959571, 17376078, 27226615" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15752199, 16959571, 17376078, 27226615; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="lytic transglycosylase; autolysin required for complete dissolution of the asymmetric septum (stage II sporulation)" /protein_id="NP_391556.1" /db_xref="EnsemblGenomes-Gn:BSU36750" /db_xref="EnsemblGenomes-Tr:CAB15692" /db_xref="GOA:P07372" /db_xref="InterPro:IPR013486" /db_xref="InterPro:IPR013693" /db_xref="InterPro:IPR014225" /db_xref="SubtiList:BG10766" /db_xref="UniProtKB/Swiss-Prot:P07372" /translation="MKQFAITLSVLCALILLVPTLLVIPFQHNKEAGASVESEKTAVS TKPASKGAETLKASPVSIPVYRTANQSVENIPLEEYVIGVVASEMPATFKPEALKAQA LAARTFIVRLMVSNSAVEAPKGSLVDDTQMFQVYKSKAELKKQWGTSYETKLKKITDA VASTQGKILTYNNQPIEASFFSTSNGYTENAEAYWTSAIPYLKSVKSPWDKKSPKYKA TKTFTAAEFQQKLGVKLDGSSAVGKITGETPGHQVATAVINGKTLKGRDIREKLGLNS ADFEWKRNGDTITVTTRGFGHGVGMSQYGANFMAKEGKTVDDIVKYYYQGTQISEADA FLNKYMAKK*" /label="spoIID CDS" gene complement(3291632..3292663) /gene="spoIID" /locus_tag="BSU_36750" /old_locus_tag="BSU36750" /label="spoIID gene" promotor_-10 3291642..3291661 /Source="Nicolas_upshift_promotors" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(3291648) /Source="Nicolas_upshifts" /id="D1904" /incds=0 /nref=56 /ntot=156 /MaxReadThrough="0.87893" /MaxDrop="6.31542" /score="12.1351765" /energy="-8.7" /TU="NA" /idTUdmin="U2888" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts 3291660 /Source="Nicolas_upshifts" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3292691..3292709) /Source="Nicolas_upshift_promotors" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3292704) /Source="Nicolas_upshifts" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3292706..3292823) /Source="Nicolas_S_feature" /locus_tag="new_3777796_3777913_c" /HighExp="S8, M40t90, M9-stat, B36, LBGtran, G180, H2O2, M0t90, BT, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigI, SigWXY, SigA" /TUshortPSig="0.947, 0.999, 1, 0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1419" promotor_-35 complement(3292725..3292730) /Source="Nicolas_upshift_promotors" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3292765..3292770 /Source="Nicolas_upshift_promotors" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3292782..3295442 /Source="Nicolas_S_feature" /locus_tag="new_3777872_3780532" /HighExp="S8, S6, S7, S4, S3, C30, S5, T5.0H, T3.30H, BT" /AntisenseName="murAA" /AntisenseCor="5.8371061376981899E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.971" /TUlongSig="NA" /TUlongPSig="NA" /label="S1420" upshifts 3292782 /Source="Nicolas_upshifts" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3292786..3292804 /Source="Nicolas_upshift_promotors" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3292859..3294169) /gene="murAA" /locus_tag="BSU_36760" /old_locus_tag="BSU36760" /EC_number="2.5.1.7" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 14763982, 17714441" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14763982, 17714441; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine 1-carboxyvinyltransferase" /protein_id="NP_391557.1" /db_xref="EnsemblGenomes-Gn:BSU36760" /db_xref="EnsemblGenomes-Tr:CAB15693" /db_xref="GOA:P70965" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR005750" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG11955" /db_xref="UniProtKB/Swiss-Prot:P70965" /translation="MEKIIVRGGQKLNGTVKVEGAKNAVLPVIAASLLASEEKSVICD VPTLSDVYTINEVLRHLGADVHFENNEVTVNASYALQTEAPFEYVRKMRASVLVMGPL LARTGHARVALPGGCAIGSRPIDQHLKGFEAMGAEIKVGNGFIEAEVKGRLQGAKIYL DFPSVGATENLIMAAALAEGTTTLENVAKEPEIVDLANYINGMGGKIRGAGTGTIKIE GVEKLHGVKHHIIPDRIEAGTFMVAAAITEGNVLVKGAVPEHLTSLIAKMEEMGVTIK DEGEGLRVIGPKELKPIDIKTMPHPGFPTDMQSQMMALLLRASGTSMITETVFENRFM HAEEFRRMNGDIKIEGRSVIINGPVQLQGAEVAATDLRAGAALILAGLVAEGHTRVTE LKHLDRGYVDFHQKLAALGADIERVNDESASEQENKEVVSDLNA*" /label="murAA CDS" gene complement(3292859..3294169) /gene="murAA" /locus_tag="BSU_36760" /old_locus_tag="BSU36760" /label="murAA gene" downshifts complement(3292868) /Source="Nicolas_upshifts" /id="D1905" /incds=0 /nref=171 /ntot=256 /MaxReadThrough="5.3301" /MaxDrop="5.5423" /score="31.3825723" /energy="-11.8" /TU="U2890,U2891,U2892,U2894" /idTUdmin="U2890" /TUdmin="-98" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3294193..3294212) /Source="Nicolas_upshift_promotors" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3294200) /Source="Nicolas_upshifts" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3294203..3294943) /gene="ywmB" /locus_tag="BSU_36770" /old_locus_tag="BSU36770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391558.1" /db_xref="EnsemblGenomes-Gn:BSU36770" /db_xref="EnsemblGenomes-Tr:CAB15694" /db_xref="InterPro:IPR014794" /db_xref="InterPro:IPR036209" /db_xref="PDB:2FPN" /db_xref="SubtiList:BG12473" /db_xref="UniProtKB/Swiss-Prot:O32277" /translation="MKKKQVSHAIIISVMLSFVIAVFHTIHASELTPLAQMAEGMERQ DVSIDKWTLHAKQNLSLTEKEFYQKVQRLKQEYRQYDWVIAREDKMIKAIGTYTDKKN RTSFRLQLVTTLKKHNPTSYLLYEQMSLETPDSWNDTYEQFERETLGIFQEKVVIFTC LNGHLDDNMNIVLQKKANQLLNEFQARSVEHVVEPNFVSISAFTDEWEEYIMTSKHKM NLQIALRSAGMGGKHTVTVGTPIVTTEY*" /label="ywmB CDS" gene complement(3294203..3294943) /gene="ywmB" /locus_tag="BSU_36770" /old_locus_tag="BSU36770" /label="ywmB gene" promotor_-35 complement(3294226..3294235) /Source="Nicolas_upshift_promotors" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3294574) /Source="Nicolas_upshifts" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3294576..3294584) /Source="Nicolas_upshift_promotors" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3294598..3294606) /Source="Nicolas_upshift_promotors" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3294698..3294713) /Source="Nicolas_upshift_promotors" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3294706) /Source="Nicolas_upshifts" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3294726..3294735) /Source="Nicolas_upshift_promotors" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3294944..3295071) /Source="Nicolas_S_feature" /locus_tag="new_3780034_3780161_c" /HighExp="UNK1, S2, Lbexp, MG 60, MG 15, M9-tran, M/G, G135, MG 5, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1421" CDS complement(3295072..3295302) /gene="ywzB" /locus_tag="BSU_36780" /old_locus_tag="BSU36780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391559.1" /db_xref="EnsemblGenomes-Gn:BSU36780" /db_xref="EnsemblGenomes-Tr:CAB15695" /db_xref="GOA:O32278" /db_xref="InterPro:IPR009526" /db_xref="SubtiList:BG14163" /db_xref="UniProtKB/Swiss-Prot:O32278" /translation="MSVLGQQAAIGIVVHLIFIAVTWWALQAVNIDPLIKKGKVVQAR LLMILLTIAIGTAVANFFLDYLNYSQQLPYLF*" /label="ywzB CDS" gene complement(3295072..3295302) /gene="ywzB" /locus_tag="BSU_36780" /old_locus_tag="BSU36780" /label="ywzB gene" S_feature complement(3295303..3295565) /Source="Nicolas_S_feature" /locus_tag="new_3780393_3780655_c" /HighExp="UNK1, S2, Lbexp, MG 5, M9-tran, M/G, MG 15, MG 60, GM 15, MG t5" /AntisenseName="ywmA" /AntisenseCor="-0.24099136307237601" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1422" misc_feature 3295438..3295457 /Source="Nicolas_upshift_promotors" /id="U2893" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=411 /SigmaFactorBS="cggaataatcagccaaatctagggctaatccccgcttaaagt gcgattcttttaCATGGTATACTTTATTGGAAaggagctggcaaatgtgaatcattct t" /listShort="ywmA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3295444 /Source="Nicolas_upshifts" /id="U2893" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=411 /SigmaFactorBS="cggaataatcagccaaatctagggctaatccccgcttaaagt gcgattcttttaCATGGTATACTTTATTGGAAaggagctggcaaatgtgaatcattct t" /listShort="ywmA" /GFF_Attribute="listLong" /label="upshifts" CDS 3295472..3295945 /gene="ywmA" /locus_tag="BSU_36790" /old_locus_tag="BSU36790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391560.1" /db_xref="EnsemblGenomes-Gn:BSU36790" /db_xref="EnsemblGenomes-Tr:CAB15696" /db_xref="SubtiList:BG12472" /db_xref="UniProtKB/Swiss-Prot:P70958" /translation="MNHSFFQPEKQYGEDLPIFDQEWEAIAFYYDYRQSQIEELNELC QFFNISLTYTRESLEELENLYFQSIQELLLADWNLPIEEFEKMISVYLIDCVIARHED AEWVVKPYPYKDGAYTLGFRRHRKSWHTMNACDGLYLRPKEDRPLLSLFDSLVRS*" /label="ywmA CDS" gene 3295472..3295945 /gene="ywmA" /locus_tag="BSU_36790" /old_locus_tag="BSU36790" /label="ywmA gene" promotor_-10 complement(3295549..3295568) /Source="Nicolas_upshift_promotors" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="promotor_-10" upshifts complement(3295565) /Source="Nicolas_upshifts" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="upshifts" S_feature complement(3295567..3295950) /Source="Nicolas_S_feature" /locus_tag="new_3780657_3781040_c" /HighExp="G135, G180, G150, H2O2, Oxctl, Paraq, Cold, M9-stat, C30, S0" /AntisenseName="ywmA" /AntisenseCor="-1.9581968147303098E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1423" promotor_-35 complement(3295583..3295586) /Source="Nicolas_upshift_promotors" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="promotor_-35" CDS complement(3295979..3296377) /gene="atpC" /locus_tag="BSU_36800" /old_locus_tag="BSU36800" /EC_number="3.6.3.14" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:8021203, 12837747, 15347741, 22720735, 23967352" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 12837747, 15347741, 22720735, 23967352; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit epsilon, F1 subunit)" /protein_id="NP_391561.1" /db_xref="EnsemblGenomes-Gn:BSU36800" /db_xref="EnsemblGenomes-Tr:CAB15697" /db_xref="GOA:P37812" /db_xref="InterPro:IPR001469" /db_xref="InterPro:IPR020546" /db_xref="InterPro:IPR020547" /db_xref="InterPro:IPR036771" /db_xref="InterPro:IPR036794" /db_xref="SubtiList:BG10822" /db_xref="UniProtKB/Swiss-Prot:P37812" /translation="MKTVKVNIVTPDGPVYDADIEMVSVRAESGDLGILPGHIPTVAP LKIGAVRLKKDGQTEMVAVSGGFVEVRPDHVTILAQAAETAEGIDKERAEAARQRAQE RLNSQSDDTDIRRAELALQRALNRLDVAGK*" /label="atpC CDS" gene complement(3295979..3296377) /gene="atpC" /locus_tag="BSU_36800" /old_locus_tag="BSU36800" /label="atpC gene" downshifts complement(3295995) /Source="Nicolas_upshifts" /id="D1906" /incds=0 /nref=283 /ntot=320 /MaxReadThrough="4.15968" /MaxDrop="7.84101" /score="22.7623678" /energy="-10.8" /TU="U2897,U2899" /idTUdmin="U2895" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3296369..3296387) /Source="Nicolas_upshift_promotors" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3296378) /Source="Nicolas_upshifts" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3296401..3296407) /Source="Nicolas_upshift_promotors" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3296401..3297822) /gene="atpD" /locus_tag="BSU_36810" /old_locus_tag="BSU36810" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 18174126, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 18174126, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit beta, component F1)" /protein_id="NP_391562.1" /db_xref="EnsemblGenomes-Gn:BSU36810" /db_xref="EnsemblGenomes-Tr:CAB15698" /db_xref="GOA:P37809" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004100" /db_xref="InterPro:IPR005722" /db_xref="InterPro:IPR020003" /db_xref="InterPro:IPR024034" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036121" /db_xref="SubtiList:BG10821" /db_xref="UniProtKB/Swiss-Prot:P37809" /translation="MKKGRVSQVLGPVVDVRFEDGHLPEIYNAIKISQPAASENEVGI DLTLEVALHLGDDTVRTIAMASTDGVQRGMEAVDTGAPISVPVGDVTLGRVFNVLGEN IDLNEPVPADAKKDPIHRQAPSFDQLSTEVEILETGIKVVDLLAPYIKGGKIGLFGGA GVGKTVLIQELINNIAQEHGGISVFAGVGERTREGNDLFYEMSDSGVINKTAMVFGQM NEPPGARMRVALTGLTMAEHFRDVQGQDVLFFIDNIFRFTQAGSEVSALLGRMPSAVG YQPTLATEMGQLQERITSTNVGSVTSIQAIYVPADDYTDPAPATTFAHLDATTNLERK LTEMGIYPAVDPLASTSRALAPEIVGEEHYAVAREVQSTLQRYKELQDIIAILGMDEL GEEDKLVVHRARRIQFFLSQNFHVAEQFTGQKGSYVPVKETVQGFKEILAGKYDHLPE DAFRLVGRIEEVVEKAKEMGVEV*" /label="atpD CDS" gene complement(3296401..3297822) /gene="atpD" /locus_tag="BSU_36810" /old_locus_tag="BSU36810" /label="atpD gene" CDS complement(3297848..3298711) /gene="atpG" /locus_tag="BSU_36820" /old_locus_tag="BSU36820" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 18174126, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 18174126, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit gamma, component F1)" /protein_id="NP_391563.1" /db_xref="EnsemblGenomes-Gn:BSU36820" /db_xref="EnsemblGenomes-Tr:CAB15699" /db_xref="GOA:P37810" /db_xref="InterPro:IPR000131" /db_xref="InterPro:IPR023632" /db_xref="InterPro:IPR035968" /db_xref="SubtiList:BG10820" /db_xref="UniProtKB/Swiss-Prot:P37810" /translation="MASLRDIKSRITSTKKTSQITKAMQMVSAAKLNRAENNAKSFVP YMDKIQEVVSNVGRVSGNVKHPMLLSREVKKTAYLVITSDRGLAGAFNSSVLRSAYQA MQERHQSKDEYAVIAIGRVGRDFFKKREIPIISELTGLGDEVTFTEIKDLARQTIQMF IDGAFDELHLVYNHFVSAITQEVTEKKLLPLSDLGSGGGKRTASYEFEPSEEEVLEVL LPQYAESLIFGALLDSKASEHAARMTAMKNATDNAKELIDSLSLSYNRARQAAITQEI TEIVGGAAALE*" /label="atpG CDS" gene complement(3297848..3298711) /gene="atpG" /locus_tag="BSU_36820" /old_locus_tag="BSU36820" /label="atpG gene" S_feature complement(3298712..3298787) /Source="Nicolas_S_feature" /locus_tag="new_3783802_3783877_c" /HighExp="S0, S2, MG-0.2, MG-0.1, Mal, G150, BI, M0t45, G180, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1424" CDS complement(3298788..3300296) /gene="atpA" /locus_tag="BSU_36830" /old_locus_tag="BSU36830" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 1655755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 1655755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit alpha, component F1)" /protein_id="NP_391564.1" /db_xref="EnsemblGenomes-Gn:BSU36830" /db_xref="EnsemblGenomes-Tr:CAB15700" /db_xref="GOA:P37808" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR000793" /db_xref="InterPro:IPR004100" /db_xref="InterPro:IPR005294" /db_xref="InterPro:IPR020003" /db_xref="InterPro:IPR023366" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033732" /db_xref="InterPro:IPR036121" /db_xref="SubtiList:BG10819" /db_xref="UniProtKB/Swiss-Prot:P37808" /translation="MSIKAEEISTLIKQQIQNYQSDIEVQDVGTVIQVGDGIARVHGL DNCMAGELVEFSNGVLGMAQNLEESNVGIVILGPFSEIREGDEVKRTGRIMEVPVGEE LIGRIVNPLGQPVDGLGPILTSKTRPIESPAPGVMDRKSVHEPLQTGIKAIDALIPIG RGQRELIIGDRQTGKTSVAIDAILNQKDQDMICVYVAIGQKESTVRGVVETLRKHGAL DYTIVVTASASQPAPLLYLAPYAGVTMAEEFMYNGKHVLVVYDDLSKQAAAYRELSLL LRRPPGREAFPGDVFYLHSRLLERAAKLSDAKGAGSITALPFVETQAGDISAYIPTNV ISITDGQIFLQSDLFFSGVRPAINAGLSVSRVGGSAQIKAMKKVSGTLRLDLASYREL EAFAQFGSDLDQATQAKLNRGARTVEVLKQDLNKPLPVEKQVAILYALTKGYLDDIPV ADIRRFEEEYYMYLDQNHKDLLDGIAKTGNLPADEDFKAAIEGFKRTFAPSN*" /label="atpA CDS" gene complement(3298788..3300296) /gene="atpA" /locus_tag="BSU_36830" /old_locus_tag="BSU36830" /label="atpA gene" CDS complement(3300313..3300858) /gene="atpH" /locus_tag="BSU_36840" /old_locus_tag="BSU36840" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 1655755, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 1655755, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit delta, component F1)" /protein_id="NP_391565.1" /db_xref="EnsemblGenomes-Gn:BSU36840" /db_xref="EnsemblGenomes-Tr:CAB15701" /db_xref="GOA:P37811" /db_xref="InterPro:IPR000711" /db_xref="InterPro:IPR020781" /db_xref="InterPro:IPR026015" /db_xref="SubtiList:BG10818" /db_xref="UniProtKB/Swiss-Prot:P37811" /translation="MSGSAVSKRYASALFDIANESAQLNQVEEELIVVKQVFQNEKAL NDVLNHPKVPAAKKKELIQNAFGSLSQSVLNTIFLLIDRHRAAIVPELTDEFIKLANV ARQTEDAIVYSVKPLTDAEMLPLSQVFAKKAGVASLRIRNEVQTDLIGGIKVRIGNRI YDGSVSGKLQRIERQLAGENR*" /label="atpH CDS" gene complement(3300313..3300858) /gene="atpH" /locus_tag="BSU_36840" /old_locus_tag="BSU36840" /label="atpH gene" CDS complement(3300855..3301367) /gene="atpF" /locus_tag="BSU_36850" /old_locus_tag="BSU36850" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit b, component F0)" /protein_id="NP_391566.1" /db_xref="EnsemblGenomes-Gn:BSU36850" /db_xref="EnsemblGenomes-Tr:CAB15702" /db_xref="GOA:P37814" /db_xref="InterPro:IPR002146" /db_xref="InterPro:IPR005864" /db_xref="InterPro:IPR028987" /db_xref="SubtiList:BG10817" /db_xref="UniProtKB/Swiss-Prot:P37814" /translation="MSQLPLELGLSFNGGDILFQLLAMLILLALLKKYALGPLLNIMK QREDHIAGEITSAEEKNKEAQQLIEEQRVLLKEARQESQTLIENAKKLGEKQKEEIIQ AARAESERLKEAARTEIVKEKEQAVSALREQVASLSVMIASKVIEKELDEQAQEKLIQ DYLKEVGESR*" /label="atpF CDS" gene complement(3300855..3301367) /gene="atpF" /locus_tag="BSU_36850" /old_locus_tag="BSU36850" /label="atpF gene" S_feature complement(3301368..3301529) /Source="Nicolas_S_feature" /locus_tag="new_3786458_3786619_c" /HighExp="S2, Lbstat, Mal, M40t90, M0t90, G150, MG-0.1, G135, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1425" CDS complement(3301530..3301742) /gene="atpE" /locus_tag="BSU_36860" /old_locus_tag="BSU36860" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit c, component F0)" /protein_id="NP_391567.1" /db_xref="EnsemblGenomes-Gn:BSU36860" /db_xref="EnsemblGenomes-Tr:CAB15703" /db_xref="GOA:P37815" /db_xref="InterPro:IPR000454" /db_xref="InterPro:IPR002379" /db_xref="InterPro:IPR005953" /db_xref="InterPro:IPR020537" /db_xref="InterPro:IPR035921" /db_xref="SubtiList:BG10816" /db_xref="UniProtKB/Swiss-Prot:P37815" /translation="MNLIAAAIAIGLGALGAGIGNGLIVSRTVEGIARQPEAGKELRT LMFMGIALVEALPIIAVVIAFLAFFG*" /label="atpE CDS" gene complement(3301530..3301742) /gene="atpE" /locus_tag="BSU_36860" /old_locus_tag="BSU36860" /label="atpE gene" CDS complement(3301788..3302522) /gene="atpB" /locus_tag="BSU_36870" /old_locus_tag="BSU36870" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit a, component F0)" /protein_id="NP_391568.1" /db_xref="EnsemblGenomes-Gn:BSU36870" /db_xref="EnsemblGenomes-Tr:CAB15704" /db_xref="GOA:P37813" /db_xref="InterPro:IPR000568" /db_xref="InterPro:IPR023011" /db_xref="InterPro:IPR035908" /db_xref="SubtiList:BG10815" /db_xref="UniProtKB/Swiss-Prot:P37813" /translation="MNHGYRTIEFLGLTFNLTNILMITVASVIVLLIAILTTRTLSIR PGKAQNFMEWIVDFVRNIIGSTMDLKTGANFLALGVTLLMYIFVSNMLGLPFSITIGH ELWWKSPTADPAITLTLAVMVVALTHYYGVKMKGLKEYSKDYLRPVPFMLPMKIIEEF ANTLTLGLRLYGNIFAGEILLGLLAGLATSHYSQSVALGLVGTIGAILPMLAWQAFSL FIGAIQAFIFTMLTMVYMSHKISHDH*" /label="atpB CDS" gene complement(3301788..3302522) /gene="atpB" /locus_tag="BSU_36870" /old_locus_tag="BSU36870" /label="atpB gene" promotor_no_box 3302336..3302436 /Source="Nicolas_upshift_promotors" /id="U2896" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.002997002997003" /xcortree=76 /SigmaFactorBS="taatattgcggacgaaatcaacaatccattccataaagttct gggcttttccgggacggatcgaaagcgttcttgtcgtcaatatagcaatcaataaaac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3302396 /Source="Nicolas_upshifts" /id="U2896" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.002997002997003" /xcortree=76 /SigmaFactorBS="taatattgcggacgaaatcaacaatccattccataaagttct gggcttttccgggacggatcgaaagcgttcttgtcgtcaatatagcaatcaataaaac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3302530..3302913) /gene="atpI" /locus_tag="BSU_36880" /old_locus_tag="BSU36880" /function="16.1: Circulate" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12917488, 15849754, 16850406, 23123906" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12917488, 15849754, 16850406, 23123906; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit i)" /protein_id="NP_391569.1" /db_xref="EnsemblGenomes-Gn:BSU36880" /db_xref="EnsemblGenomes-Tr:CAB15705" /db_xref="GOA:P37816" /db_xref="InterPro:IPR005598" /db_xref="SubtiList:BG10814" /db_xref="UniProtKB/Swiss-Prot:P37816" /translation="MDDPKLTFSRQRKYLLFILAVYVLGYGLTAYKTVFLGLILGTVF SLFNFLLLVRRMNAFDRAVEKGKSIRSLGSAARWCNAILAVAVAYKNPEYFHMASTVI GLMTIYPVIMIDSFIQLKRSSMEER*" /label="atpI CDS" gene complement(3302530..3302913) /gene="atpI" /locus_tag="BSU_36880" /old_locus_tag="BSU36880" /label="atpI gene" misc_feature complement(3302602..3302620) /Source="Nicolas_upshift_promotors" /id="U2897" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=2708 /SigmaFactorBS="gctgtggctgttgcctataaaaatcccgaatactttcatatg gcAAGTACAGTTATTGGATTAatgacaatataccctgtcattatgatagattccttta t" /listShort="atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3302604) /Source="Nicolas_upshifts" /id="U2897" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=2708 /SigmaFactorBS="gctgtggctgttgcctataaaaatcccgaatactttcatatg gcAAGTACAGTTATTGGATTAatgacaatataccctgtcattatgatagattccttta t" /listShort="atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="upshifts" S_feature complement(3302914..3303184) /Source="Nicolas_S_feature" /locus_tag="new_3788004_3788274_c" /HighExp="M9-stat, T1.30H, T0.30H, T1.0H, UNK1, B60, G135, G180, G150, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.999" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.96" /label="S1426" promotor_-35 3303146..3303155 /Source="Nicolas_upshift_promotors" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3303155 /Source="Nicolas_upshifts" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3303160..3303179) /Source="Nicolas_upshift_promotors" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-10" promotor_-10 3303169..3303188 /Source="Nicolas_upshift_promotors" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3303184) /Source="Nicolas_upshifts" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="upshifts" S_feature complement(3303186..3303307) /Source="Nicolas_S_feature" /locus_tag="new_3788276_3788397_c" /HighExp="Etha, G180, H2O2, G135, Oxctl, G150, LBGexp, dia15, B36, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.96" /label="S1427" promotor_-35 complement(3303192..3303199) /Source="Nicolas_upshift_promotors" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-35" CDS complement(3303336..3303965) /gene="upp" /locus_tag="BSU_36890" /old_locus_tag="BSU36890" /EC_number="2.4.2.9" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7798145, 15689504, 15716449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7798145, 15689504, 15716449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uracil phosphoribosyltransferase" /protein_id="NP_391570.1" /db_xref="EnsemblGenomes-Gn:BSU36890" /db_xref="EnsemblGenomes-Tr:CAB15706" /db_xref="GOA:P39149" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005765" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR034332" /db_xref="SubtiList:BG10945" /db_xref="UniProtKB/Swiss-Prot:P39149" /translation="MGKVYVFDHPLIQHKLTYIRNENTGTKDFRELVDEVATLMAFEI TRDLPLEEVDINTPVQAAKSKVISGKKLGVVPILRAGLGMVDGILKLIPAAKVGHVGL YRDPETLKPVEYYVKLPSDVEEREFIVVDPMLATGGSAVEAIHSLKKRGAKNIRFMCL VAAPEGVEELQKHHSDVDIYIAALDEKLNEKGYIVPGLGDAGDRMFGTK*" /label="upp CDS" gene complement(3303336..3303965) /gene="upp" /locus_tag="BSU_36890" /old_locus_tag="BSU36890" /label="upp gene" downshifts complement(3303352) /Source="Nicolas_upshifts" /id="D1907" /incds=0 /nref=180 /ntot=252 /MaxReadThrough="5.83241" /MaxDrop="5.91252" /score="1.39547358" /energy="-7.3" /TU="U2900,U2901" /idTUdmin="U2900" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3304009..3304028) /Source="Nicolas_upshift_promotors" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-10" upshifts complement(3304032) /Source="Nicolas_upshifts" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="upshifts" promotor_-35 complement(3304043..3304050) /Source="Nicolas_upshift_promotors" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-35" CDS complement(3304100..3305347) /gene="glyA" /locus_tag="BSU_36900" /old_locus_tag="BSU36900" /EC_number="2.1.2.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 11902725, 12682299, 12686103, 12923093, 15865438, 18483062" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11902725, 12682299, 12686103, 12923093, 15865438, 18483062; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine hydroxymethyltransferase" /protein_id="NP_391571.1" /db_xref="EnsemblGenomes-Gn:BSU36900" /db_xref="EnsemblGenomes-Tr:CAB15707" /db_xref="GOA:P39148" /db_xref="InterPro:IPR001085" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR019798" /db_xref="SubtiList:BG10944" /db_xref="UniProtKB/Swiss-Prot:P39148" /translation="MKHLPAQDEQVFNAIKNERERQQTKIELIASENFVSEAVMEAQG SVLTNKYAEGYPGKRYYGGCEHVDVVEDIARDRAKEIFGAEHVNVQPHSGAQANMAVY FTILEQGDTVLGMNLSHGGHLTHGSPVNFSGVQYNFVEYGVDKETQYIDYDDVREKAL AHKPKLIVAGASAYPRTIDFKKFREIADEVGAYFMVDMAHIAGLVAAGLHPNPVPYAD FVTTTTHKTLRGPRGGMILCREEFGKKIDKSIFPGIQGGPLMHVIAAKAVSFGEVLQD DFKTYAQNVISNAKRLAEALTKEGIQLVSGGTDNHLILVDLRSLGLTGKVAEHVLDEI GITSNKNAIPYDPEKPFVTSGIRLGTAAVTSRGFDGDALEEVGAIIALALKNHEDEGK LEEARQRVAALTDKFPLYKELDY*" /label="glyA CDS" gene complement(3304100..3305347) /gene="glyA" /locus_tag="BSU_36900" /old_locus_tag="BSU36900" /label="glyA gene" downshifts complement(3304123) /Source="Nicolas_upshifts" /id="D1908" /incds=0 /nref=183 /ntot=229 /MaxReadThrough="5.99283" /MaxDrop="6.62881" /score="22.1245386" /energy="-15.8" /TU="U2901" /idTUdmin="U2902" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3305389..3305408) /Source="Nicolas_upshift_promotors" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3305406) /Source="Nicolas_upshifts" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3305408..3305492) /Source="Nicolas_S_feature" /locus_tag="new_3790498_3790582_c" /HighExp="dia5, C90, dia15, Diami, Lbtran, LPhT, M40t45, H2O2, BI, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.96, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S1428" promotor_-35 complement(3305423..3305428) /Source="Nicolas_upshift_promotors" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3305537) /Source="Nicolas_upshifts" /id="D1909" /incds=0 /nref=3 /ntot=12 /MaxReadThrough="7.23859" /MaxDrop="5.0386" /score="-3.86767322" /energy="-4.3" /TU="U2902,U2903" /idTUdmin="U2904" /TUdmin=1137 /isTUend="FALSE" /label="downshifts" CDS complement(3305554..3306096) /gene="ywlG" /locus_tag="BSU_36910" /old_locus_tag="BSU36910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15995210, 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391572.1" /db_xref="EnsemblGenomes-Gn:BSU36910" /db_xref="EnsemblGenomes-Tr:CAB15708" /db_xref="InterPro:IPR006340" /db_xref="InterPro:IPR028345" /db_xref="SubtiList:BG10943" /db_xref="UniProtKB/Swiss-Prot:P39157" /translation="MNELKQTWKTMLSEFQDQAELKQDQLFVLGCSTSEVAGSRIGTS GSVDIAESIYSGLAELREKTGIHLAFQCCEHLNRALVVEAETAKLFRLPTVSAVPVPK AGGAMASYAFKQMKSPVLVETIQADAGIDIGDTFIGMHLKPVAVPVRVSQNSLGSAHV TLARTRPKLIGGVRAVYECE*" /label="ywlG CDS" gene complement(3305554..3306096) /gene="ywlG" /locus_tag="BSU_36910" /old_locus_tag="BSU36910" /label="ywlG gene" CDS complement(3306109..3306558) /gene="rpiB" /locus_tag="BSU_36920" /old_locus_tag="BSU36920" /EC_number="5.3.1.6" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15755726, 15995210, 18640127, 19446032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15755726, 15995210, 18640127, 19446032; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-ribose 5-phosphate epimerase (promiscuous)" /protein_id="NP_391573.1" /db_xref="EnsemblGenomes-Gn:BSU36920" /db_xref="EnsemblGenomes-Tr:CAB15709" /db_xref="GOA:P39156" /db_xref="InterPro:IPR003500" /db_xref="InterPro:IPR004785" /db_xref="InterPro:IPR036569" /db_xref="SubtiList:BG10942" /db_xref="UniProtKB/Swiss-Prot:P39156" /translation="MKVAIASDHGGVHIRNEIKELMDELQIEYIDMGCDCGSGSVDYP DYAFPVAEKVVSGEVDRGILICGTGIGMSISANKVKGIRCALAHDTFSAKATREHNDT NILAMGERVIGPGLAREIAKIWLTTEFTGGRHQTRIGKISDYEEKNL*" /label="rpiB CDS" gene complement(3306109..3306558) /gene="rpiB" /locus_tag="BSU_36920" /old_locus_tag="BSU36920" /label="rpiB gene" S_feature complement(3306559..3306658) /Source="Nicolas_S_feature" /locus_tag="new_3791649_3791748_c" /HighExp="Diami, dia5, C90, dia15, LPhT, M40t45, LBGtran, Lbtran, T-0.40H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.68276199999999998" /TUshortSig="SigA, SigA" /TUshortPSig="0.96, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S1429" promotor_-10 complement(3306650..3306669) /Source="Nicolas_upshift_promotors" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="promotor_-10" upshifts complement(3306658) /Source="Nicolas_upshifts" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="upshifts" promotor_-35 complement(3306683..3306690) /Source="Nicolas_upshift_promotors" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="promotor_-35" CDS complement(3306715..3307167) /gene="prpB" /locus_tag="BSU_36930" /old_locus_tag="BSU36930" /EC_number="3.9.1.2" /EC_number="3.1.3.48" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15995210, 22517742, 24825175, 25610436, 27524296" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995210, 22517742, 24825175, 25610436, 27524296; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein-arginine(tyrosine moonlighting) phosphatase (oxidative stress)" /protein_id="NP_391574.1" /db_xref="EnsemblGenomes-Gn:BSU36930" /db_xref="EnsemblGenomes-Tr:CAB15710" /db_xref="GOA:P39155" /db_xref="InterPro:IPR017867" /db_xref="InterPro:IPR023485" /db_xref="InterPro:IPR036196" /db_xref="PDB:1ZGG" /db_xref="PDB:4ETI" /db_xref="PDB:4ETN" /db_xref="PDB:4KK3" /db_xref="PDB:4KK4" /db_xref="SubtiList:BG10941" /db_xref="UniProtKB/Swiss-Prot:P39155" /translation="MDIIFVCTGNTCRSPMAEALFKSIAEREGLNVNVRSAGVFASPN GKATPHAVEALFEKHIALNHVSSPLTEELMESADLVLAMTHQHKQIIASQFGRYRDKV FTLKEYVTGSHGDVLDPFGGSIDIYKQTRDELEELLRQLAKQLKKDRR*" /label="prpB CDS" gene complement(3306715..3307167) /gene="prpB" /locus_tag="BSU_36930" /old_locus_tag="BSU36930" /label="prpB gene" promotor_-10 complement(3307184..3307203) /Source="Nicolas_upshift_promotors" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="promotor_-10" upshifts complement(3307202) /Source="Nicolas_upshifts" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="upshifts" promotor_-35 complement(3307218..3307221) /Source="Nicolas_upshift_promotors" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="promotor_-35" CDS complement(3307243..3307800) /gene="mntP" /locus_tag="BSU_36940" /old_locus_tag="BSU36940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 25774656, 25794618, 26076491; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="manganese efflux pump" /protein_id="NP_391575.1" /db_xref="EnsemblGenomes-Gn:BSU36940" /db_xref="EnsemblGenomes-Tr:CAB15711" /db_xref="GOA:P39154" /db_xref="InterPro:IPR003810" /db_xref="InterPro:IPR022929" /db_xref="SubtiList:BG10940" /db_xref="UniProtKB/Swiss-Prot:P39154" /translation="MSDLFIGELITLSIMAFALGMDAFSVGLGMGMVKLRKKQIFYIG FIIGLFHVIMPLAGMAAGNMLSGLLGVLAVYIGGALLFVLGVQMLMASFKQSEERFMS PAGPGLLLFAIGVSLDSFSVGLSLGIYGSHPLLTITLFGLFSMMLTWLGLLVGKQVQS WLGTYSEALGGIILIVFGLKLLLPI*" /label="mntP CDS" gene complement(3307243..3307800) /gene="mntP" /locus_tag="BSU_36940" /old_locus_tag="BSU36940" /label="mntP gene" promotor_-10 complement(3307827..3307845) /Source="Nicolas_upshift_promotors" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="promotor_-10" upshifts complement(3307840) /Source="Nicolas_upshifts" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="upshifts" promotor_-35 complement(3307861..3307866) /Source="Nicolas_upshift_promotors" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="promotor_-35" CDS complement(3307879..3308919) /gene="tsaC" /locus_tag="BSU_36950" /old_locus_tag="BSU36950" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 16014871, 16890019, 17005971, 19884342, 20606270, 21775474, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323, 27913733" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16014871, 16890019, 17005971, 19884342, 20606270, 21775474, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323, 27913733; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; threonine-dependent ADP-forming ATPase" /protein_id="NP_391576.1" /db_xref="EnsemblGenomes-Gn:BSU36950" /db_xref="EnsemblGenomes-Tr:CAB15712" /db_xref="GOA:P39153" /db_xref="InterPro:IPR005145" /db_xref="InterPro:IPR006070" /db_xref="InterPro:IPR010923" /db_xref="InterPro:IPR017945" /db_xref="SubtiList:BG10939" /db_xref="UniProtKB/Swiss-Prot:P39153" /translation="MKTKRWFVDVTDELSTNDPQIAQAAALLRENEVVAFPTETVYGL GANAKNTDAVKKIYEAKGRPSDNPLIVHIADISQLEDLTGPAPEKAKTLMKRFWPGAL TLILPCKPDALSPRVTAGLETVAIRMPDHPLALALIRESGLPIAAPSANLSGKPSPTK AEHVAHDLDGRIAGIVDGGPTGIGVESTVLSCADDIPVLLRPGGITKEQIEAVIGPIH VDKGLSDQNEKPISPGMKYTHYAPTAPLAICEGSPERIQHLIQEYQQGGRRVGVLTTE EKAGVYSADYVKSCGRRAQLETVAAGLYDALRSFDENKVDFIIAESFPDTGVGLAIMN RLMKAAGGRVIR*" /label="tsaC CDS" gene complement(3307879..3308919) /gene="tsaC" /locus_tag="BSU_36950" /old_locus_tag="BSU36950" /label="tsaC gene" downshifts complement(3307884) /Source="Nicolas_upshifts" /id="D1910" /incds=0 /nref=4 /ntot=166 /MaxReadThrough="2.08557" /MaxDrop="2.98653" /score="-6.24994287" /energy="-9.8" /TU="NA" /idTUdmin="U2905" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3308920..3308984) /Source="Nicolas_S_feature" /locus_tag="new_3794010_3794074_c" /HighExp="dia15, Diami, C90, LBGstat, Heat, LBGtran, dia5, LBGexp, Lbexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.999, 0.444" /TUlongSig="NA" /TUlongPSig="NA" /label="S1430" promotor_-10 complement(3308974..3308993) /Source="Nicolas_upshift_promotors" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3308984) /Source="Nicolas_upshifts" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3308986..3309075) /Source="Nicolas_S_feature" /locus_tag="new_3794076_3794165_c" /HighExp="S3, M9-stat, Etha, LoTm, T5.0H, S7, S8, S4, BT, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.444" /TUlongSig="NA" /TUlongPSig="NA" /label="S1431" promotor_-35 complement(3309009..3309013) /Source="Nicolas_upshift_promotors" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3309076..3309519) /gene="ywlB" /locus_tag="BSU_36960" /old_locus_tag="BSU36960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391577.1" /db_xref="EnsemblGenomes-Gn:BSU36960" /db_xref="EnsemblGenomes-Tr:CAB15713" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10938" /db_xref="UniProtKB/Swiss-Prot:P39152" /translation="MFYQLRVAREKDGDVLEAFLKQAKTSYEGVKEGFTQFLMLEDSE KNIAGCLGIEKISCDQGLLRSLVISDKLHQGHIVTLFQSMEVLCEKHQIKTVYLVANQ HSSADFLTAMGFERAESVPEELFSSDHFCESRQTEGAVLMKKASG*" /label="ywlB CDS" gene complement(3309076..3309519) /gene="ywlB" /locus_tag="BSU_36960" /old_locus_tag="BSU36960" /label="ywlB gene" CDS complement(3309586..3310260) /gene="spoIIR" /locus_tag="BSU_36970" /old_locus_tag="BSU36970" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15044948, 16824103, 18378688, 20802044, 22111992" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15044948, 16824103, 18378688, 20802044, 22111992; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator signal of pro-sigma(E) spoIIGA endopeptidase (stage II sporulation)" /protein_id="NP_391578.1" /db_xref="EnsemblGenomes-Gn:BSU36970" /db_xref="EnsemblGenomes-Tr:CAB15714" /db_xref="GOA:P39151" /db_xref="InterPro:IPR014202" /db_xref="SubtiList:BG10937" /db_xref="UniProtKB/Swiss-Prot:P39151" /translation="MKKTVIICIYIFLLLSGALVGLAKEETAQKSENQPVVIPDQAIR LRILANSDSDQDQQLKRHIRDAVNKEITTWVKDITSIEEARRVIRSKLPEIKAIAKET MEKEGANQSISVDFDKISFPTKLYGNMVYPAGEYEAILITLGNGDGANWWCVLFPPLC FLDFSNGEAVKEQEDKEASKKQTEKVLEDVTAKAEKAKKEENEEKEDGTEVKFFLVEW ISDLFS*" /label="spoIIR CDS" gene complement(3309586..3310260) /gene="spoIIR" /locus_tag="BSU_36970" /old_locus_tag="BSU36970" /label="spoIIR gene" promotor_-10 complement(3310022..3310040) /Source="Nicolas_upshift_promotors" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3310029) /Source="Nicolas_upshifts" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3310055..3310061) /Source="Nicolas_upshift_promotors" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3310292..3310309) /Source="Nicolas_upshift_promotors" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3310293) /Source="Nicolas_upshifts" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3310325..3310330) /Source="Nicolas_upshift_promotors" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3310366 /Source="Nicolas_upshifts" /id="U2908" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2167 /SigmaFactorBS="ggacaaggagagcctgggataaacgtgcagggtgaaaaaaat ctagcaagctgttaatcttattTATGGTACGATAGTGTTTTAggaggtttaagatgaa a" /listShort="ywlA" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3310370..3310389 /Source="Nicolas_upshift_promotors" /id="U2908" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2167 /SigmaFactorBS="ggacaaggagagcctgggataaacgtgcagggtgaaaaaaat ctagcaagctgttaatcttattTATGGTACGATAGTGTTTTAggaggtttaagatgaa a" /listShort="ywlA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3310401..3310763 /gene="ywlA" /locus_tag="BSU_36980" /old_locus_tag="BSU36980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391579.1" /db_xref="EnsemblGenomes-Gn:BSU36980" /db_xref="EnsemblGenomes-Tr:CAB15715" /db_xref="GOA:P39150" /db_xref="InterPro:IPR031374" /db_xref="SubtiList:BG10936" /db_xref="UniProtKB/Swiss-Prot:P39150" /translation="MKYNYTVLLSAFTMSVLYSVIYIHSFIIAALITMAFYFLFPYLI FALPLQIMMNKKPKRFSPLYLLYYLAAAFIANAIIFGMLQPSGQSLFQNTAFYLFAVL TALIYWIWDSVLLQKKEA*" /label="ywlA CDS" gene 3310401..3310763 /gene="ywlA" /locus_tag="BSU_36980" /old_locus_tag="BSU36980" /label="ywlA gene" downshifts complement(3310776) /Source="Nicolas_upshifts" /id="D1911" /incds=0 /nref=27 /ntot=242 /MaxReadThrough="2.64328" /MaxDrop="5.72616" /score="26.8558862" /energy="-11.3" /TU="U2910" /idTUdmin="U2909" /TUdmin=12 /isTUend="TRUE" /label="downshifts" CDS complement(3310780..3311067) /gene="ywkF" /locus_tag="BSU_36990" /old_locus_tag="BSU36990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391580.1" /db_xref="EnsemblGenomes-Gn:BSU36990" /db_xref="EnsemblGenomes-Tr:CAB15716" /db_xref="GOA:P45874" /db_xref="InterPro:IPR035167" /db_xref="SubtiList:BG11317" /db_xref="UniProtKB/Swiss-Prot:P45874" /translation="MKKALTAGILLIAIESMIGTIFPQALSYEAIFGVASLVLVGLAI ITSGLAVSGSDQRANYHSETKEGRTSRMKMAAAFFVAAIPSILCYLLTILF*" /label="ywkF CDS" gene complement(3310780..3311067) /gene="ywkF" /locus_tag="BSU_36990" /old_locus_tag="BSU36990" /label="ywkF gene" S_feature complement(3311068..3311126) /Source="Nicolas_S_feature" /locus_tag="new_3796158_3796216_c" /HighExp="S6, S8, S7, BT, G135, G180, Paraq, H2O2, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1432" promotor_-10 complement(3311124..3311143) /Source="Nicolas_upshift_promotors" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3311127..3311993) /gene="prmC" /locus_tag="BSU_37000" /old_locus_tag="BSU37000" /EC_number="2.1.1.297" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 16364916, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine methylase of release factor 1 (and perhaps others) at a GGQ site" /protein_id="NP_391581.1" /db_xref="EnsemblGenomes-Gn:BSU37000" /db_xref="EnsemblGenomes-Tr:CAB15717" /db_xref="GOA:P45873" /db_xref="InterPro:IPR002052" /db_xref="InterPro:IPR004556" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR019874" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11316" /db_xref="UniProtKB/Swiss-Prot:P45873" /translation="MKTIFEALKWASSYLTEAGREENAAELLLLYDTGMERSKLLASL QEPIGEDELYRFKRHVEMHKEGVPVQYIIGKEFFYGREFMVNDDVLIPRPETEEVVFH LLEKYRSVFSEDGKLEVVDVGTGSGAIAVTLALENQSFSVSAVDISKEALQVASANAE KLGANVRFYQGDLLEPFIKAGKKADIIVSNPPYISEEEMADLSEIVRFHEPLHALTDG GDGLKFYKRFMEDIPLVMKDKVFVVFEIGWKQGAAVKDLILKAFKGAEVEVLKDINGK DRTICALIHKNK*" /label="prmC CDS" gene complement(3311127..3311993) /gene="prmC" /locus_tag="BSU_37000" /old_locus_tag="BSU37000" /label="prmC gene" upshifts complement(3311140) /Source="Nicolas_upshifts" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3311156..3311165) /Source="Nicolas_upshift_promotors" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3311995..3313065) /gene="prfA" /locus_tag="BSU_37010" /old_locus_tag="BSU37010" /experiment="publication(s) with functional evidences, PMID:2186375, 1408743, 10446248, 12237459, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2186375, 1408743, 10446248, 12237459, 12682299; Product type f: factor" /codon_start=1 /transl_table=11 /product="peptide chain release factor 1" /protein_id="NP_391582.1" /db_xref="EnsemblGenomes-Gn:BSU37010" /db_xref="EnsemblGenomes-Tr:CAB15718" /db_xref="GOA:P45872" /db_xref="InterPro:IPR000352" /db_xref="InterPro:IPR004373" /db_xref="InterPro:IPR005139" /db_xref="SubtiList:BG11244" /db_xref="UniProtKB/Swiss-Prot:P45872" /translation="MLDRLKSIEERYEKLNELLSDPEVVNDPKKLREYSKEQSDIQET VDVYRQYRDASEQLADAKAMLEEKLDAEMRDMVKEEISELQKETETLSERLKVLLIPK DPNDDKNVIMEIRGAAGGEEAALFAGNLYRMYSRYAELQGWKTEVMEANVTGTGGYKE IIFMITGSGAYSKLKYENGAHRVQRVPETESGGRIHTSTATVACLPEAEEVEVDIHEK DIRVDTFASSGPGGQSVNTTMSAVRLTHLPTGVVVSCQDEKSQIKNKEKAMKVLRARI YDKFQQEAQAEYDQTRKSAVGSGDRSERIRTYNFPQNRVTDHRIGLTIQKLDQILEGK LDEVVEALIVEDQASKLQQSEG*" /label="prfA CDS" gene complement(3311995..3313065) /gene="prfA" /locus_tag="BSU_37010" /old_locus_tag="BSU37010" /label="prfA gene" downshifts complement(3311998) /Source="Nicolas_upshifts" /id="D1912" /incds=0 /nref=23 /ntot=212 /MaxReadThrough="5.17118" /MaxDrop="3.44681" /score="-9.55295942" /energy="-10.5" /TU="U2910" /idTUdmin="U2912" /TUdmin=1122 /isTUend="FALSE" /label="downshifts" downshifts 3313066 /Source="Nicolas_upshifts" /id="D1913" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="1.13519" /MaxDrop="4.28706" /score="36.3991981" /energy="-10.4" /TU="NA" /idTUdmin="U2911" /TUdmin="-990" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3313093..3313112) /Source="Nicolas_upshift_promotors" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3313117) /Source="Nicolas_upshifts" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3313119..3313230) /Source="Nicolas_S_feature" /locus_tag="new_3798209_3798320_c" /HighExp="S6, S8, S7, BT, S5, Etha, B36, C30, S4, GM 25" /AntisenseName="ywkD" /AntisenseCor="-0.43140174721346802" /AntisenseRegPval="-12.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.927" /TUlongSig="NA" /TUlongPSig="NA" /label="S1433" promotor_-35 complement(3313126..3313132) /Source="Nicolas_upshift_promotors" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3313162..3313181 /Source="Nicolas_upshift_promotors" /id="U2911" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.99100899100899" /xcortree=2343 /SigmaFactorBS="attaaccccagtcaaaagcatttcaatcccagctggaaaagc tcccTCTGCTATACTGGAATTCGAggagggatgatgttgctgaaatccatacatcata t" /listShort="ywkD, racA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3313176 /Source="Nicolas_upshifts" /id="U2911" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.99100899100899" /xcortree=2343 /SigmaFactorBS="attaaccccagtcaaaagcatttcaatcccagctggaaaagc tcccTCTGCTATACTGGAATTCGAggagggatgatgttgctgaaatccatacatcata t" /listShort="ywkD, racA" /GFF_Attribute="listLong" /label="upshifts" CDS 3313191..3313577 /gene="ywkD" /locus_tag="BSU_37020" /old_locus_tag="BSU37020" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_391583.1" /db_xref="EnsemblGenomes-Gn:BSU37020" /db_xref="EnsemblGenomes-Tr:CAB15719" /db_xref="GOA:P45871" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11315" /db_xref="UniProtKB/Swiss-Prot:P45871" /translation="MLLKSIHHIAIICSDYEKSKAFYVHKLGFQVIQETYREERGSYK LDLSLNGSYVIELFSFPDPPERQTRPEAAGLRHLAFTVGSLDKAVQELHEKGIETEPI RTDPLTGKRFTFFFDPDQLPLELYEQ*" /label="ywkD CDS" gene 3313191..3313577 /gene="ywkD" /locus_tag="BSU_37020" /old_locus_tag="BSU37020" /label="ywkD gene" promotor_-10 complement(3313212..3313230) /Source="Nicolas_upshift_promotors" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="promotor_-10" upshifts complement(3313230) /Source="Nicolas_upshifts" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="upshifts" promotor_-35 complement(3313244..3313251) /Source="Nicolas_upshift_promotors" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="promotor_-35" promotor_-35 3313645..3313653 /Source="Nicolas_upshift_promotors" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3313664..3313682 /Source="Nicolas_upshift_promotors" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3313665 /Source="Nicolas_upshifts" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="upshifts" CDS 3313699..3314253 /gene="racA" /locus_tag="BSU_37030" /old_locus_tag="BSU37030" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15780934, 17139259, 19478798, 22720735, 27059541, 27085804" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15780934, 17139259, 19478798, 22720735, 27059541, 27085804; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosome-pole-anchoring protein RacA" /protein_id="NP_391584.1" /db_xref="EnsemblGenomes-Gn:BSU37030" /db_xref="EnsemblGenomes-Tr:CAB15720" /db_xref="GOA:P45870" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR023522" /db_xref="PDB:5I41" /db_xref="PDB:5I44" /db_xref="SubtiList:BG11314" /db_xref="UniProtKB/Swiss-Prot:P45870" /translation="MNTNMVASELGVSAKTVQRWVKQLNLPAERNELGHYSFTAEDVK VLKSVQKQISEGTAIQDIHLPKSAKKRTGFLVQKTSSDTERRIEQLEQKLDTLLQQRQ DESELMARMSELERQLKQKADEGVSYQLLQHRREIDDILADLQSLTSQMKEFTAHSIP ETAAASEKTKTRKKPLLSLFKFQT*" /label="racA CDS" gene 3313699..3314253 /gene="racA" /locus_tag="BSU_37030" /old_locus_tag="BSU37030" /label="racA gene" misc_feature 3314183..3314187 /Source="Nicolas_upshift_promotors" /id="U2914" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.747252747252747" /psig="0.015984015984016" /xcortree=450 /SigmaFactorBS="ctgcaatcactgacctcacaaatgaaagaattcaccgctcat tcgatccccgagaCTGCTgctgcttctgaaaaaaccaaaacaagaaaaaaaccgctgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3314188 /Source="Nicolas_upshifts" /id="U2914" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.747252747252747" /psig="0.015984015984016" /xcortree=450 /SigmaFactorBS="ctgcaatcactgacctcacaaatgaaagaattcaccgctcat tcgatccccgagaCTGCTgctgcttctgaaaaaaccaaaacaagaaaaaaaccgctgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3314232 /Source="Nicolas_upshifts" /id="D1914" /incds=0 /nref=213 /ntot=274 /MaxReadThrough="0.82868" /MaxDrop="8.28021" /score="36.3991981" /energy="-10.4" /TU="U2913" /idTUdmin="U2914" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3314287..3315246) /gene="ywkB" /locus_tag="BSU_37040" /old_locus_tag="BSU37040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12949160, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite transporter" /protein_id="NP_391585.1" /db_xref="EnsemblGenomes-Gn:BSU37040" /db_xref="EnsemblGenomes-Tr:CAB15721" /db_xref="GOA:P45869" /db_xref="InterPro:IPR004776" /db_xref="InterPro:IPR014024" /db_xref="SubtiList:BG11313" /db_xref="UniProtKB/Swiss-Prot:P45869" /translation="MSILDILILLAPIFFVIVLGWFAGHFGSYDAKSAKGVSTLVTKY ALPAHFIAGILTTSRSEFLSQVPLMISLIIGIVGFYIIILLVCRFIFKYDLTNSSVFS LNSAQPTFAFMGIPVLGSLFGANEVAIPIAVTGIVVNAILDPLAIIIATVGESSKKNE ESGDSFWKMTGKSILHGLCEPLAAAPLISMILVLVFNFTLPELGVKMLDQLGSTTSGV ALFAVGVTVGIRKIKLSMPAIGIALLKVAVQPALMFLIALAIGLPADQTTKAILLVAF PGSAVAAMIATRFEKQEEETATAFVVSAILSLISLPIIIALTA*" /label="ywkB CDS" gene complement(3314287..3315246) /gene="ywkB" /locus_tag="BSU_37040" /old_locus_tag="BSU37040" /label="ywkB gene" downshifts complement(3314309) /Source="Nicolas_upshifts" /id="D1915" /incds=0 /nref=36 /ntot=74 /MaxReadThrough="2.86006" /MaxDrop="4.78642" /score="20.048754" /energy="-10.4" /TU="U2916" /idTUdmin="U2917" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3315284..3315302) /Source="Nicolas_upshift_promotors" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3315298) /Source="Nicolas_upshifts" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3315317..3315323) /Source="Nicolas_upshift_promotors" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3315328..3317076) /gene="maeA" /locus_tag="BSU_37050" /old_locus_tag="BSU37050" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12949160, 16788182, 20933603, 22740702, 23136871, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12949160, 16788182, 20933603, 22740702, 23136871, 24325460; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="NAD-dependent malic enzyme (conversion of malateinto pyruvate)" /protein_id="NP_391586.1" /db_xref="EnsemblGenomes-Gn:BSU37050" /db_xref="EnsemblGenomes-Tr:CAB15722" /db_xref="GOA:P45868" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG11312" /db_xref="UniProtKB/Swiss-Prot:P45868" /translation="MGYYLTWLTISRKKEICLNNIKKTKEGHLETTLRGKEVLSIPTL NKGVAFSLEERQELGLEGLLPPTVLSLDQQAQRAYEQFQAQPDRLRQNVYLSDLANRN EVLFYKLLKNHLREMLPVVYTPTVGEAIQEYSHEYRRPQGIYLSIDNIDGIEKAFENL HATAGDIDLIVATDSESILGIGDWGVGGINIAIGKLAVYTAAAGIDPSRVIPVVLDVG TNNEKLLNDPLYIGNKHERVQGERYEAFIDAYVKAALKFFPKALLHWEDLGNKNARNI MKKYNHEILTFNDDIQGTGAITLAGVLAAMKKTGASIKDQRVVIFGAGSAGIGIADQI RDTMVLAGLSEEEANKRFYTLDYRGLLTEDIEGILDFQKPYLRNADEVKDWKRDEKGQ IPFDEVVRQAKPTILIGTSGVSGAFTEEIVKEMASHVDRPVIMPMSNPTHLAEAVPED LFKWTDGKVLIATGSPFDNVEYNGVSYEIGQSNNAFAFPGLGLGSIVAEARIITPAMF AATADAIAEMVDLETPGAGLLPSIDKLQEVSIQVAIAVAEAAIKDGVANRQPEDVKQA VLDAMWTPEYKKVIAK*" /label="maeA CDS" gene complement(3315328..3317076) /gene="maeA" /locus_tag="BSU_37050" /old_locus_tag="BSU37050" /label="maeA gene" promotor_-10 complement(3315802..3315820) /Source="Nicolas_upshift_promotors" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3315810) /Source="Nicolas_upshifts" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3315835..3315841) /Source="Nicolas_upshift_promotors" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3317077..3317167) /Source="Nicolas_S_feature" /locus_tag="new_3802167_3802257_c" /HighExp="GM 25, GM 15, GM 60, GM 90, GM 120, MG-0.2, MG 15, GM 45, MG-0.1, GM 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1434" promotor_-10 complement(3317151..3317170) /Source="Nicolas_upshift_promotors" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3317167) /Source="Nicolas_upshifts" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3317184..3317191) /Source="Nicolas_upshift_promotors" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3317310) /Source="Nicolas_upshifts" /id="D1916" /incds=0 /nref=11 /ntot=126 /MaxReadThrough="2.81368" /MaxDrop="3.39095" /score="20.3711149" /energy="-7.5" /TU="NA" /idTUdmin="U2918" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(3317315..3317902) /gene="tdk" /locus_tag="BSU_37060" /old_locus_tag="BSU37060" /EC_number="2.7.1.21" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2423635, 17132103; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidine kinase" /protein_id="NP_391587.1" /db_xref="EnsemblGenomes-Gn:BSU37060" /db_xref="EnsemblGenomes-Tr:CAB15723" /db_xref="GOA:Q03221" /db_xref="InterPro:IPR001267" /db_xref="InterPro:IPR020633" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10419" /db_xref="UniProtKB/Swiss-Prot:Q03221" /translation="MYIMKQSGWLELICGSMFSGKSEELIRRVKRATYAKQEVRVFKP VIDNRYSEAAVVSHNGTSMTSYAISSAADIWDHISESTDVVAVDEVQFFDQEIVEVLS SLADKGYRVIAAGLDMDFRGEPFGVVPNIMAIAESVTKLQAVCSVCGSPASRTQRLID GKPASYDDPVILVGAAESYEARCRHHHEVPGKSKK*" /label="tdk CDS" gene complement(3317315..3317902) /gene="tdk" /locus_tag="BSU_37060" /old_locus_tag="BSU37060" /label="tdk gene" CDS complement(3317991..3318191) /gene="rpmEA" /locus_tag="BSU_37070" /old_locus_tag="BSU37070" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15049826, 16014871, 16547061, 17163968, 17310068, 19648245, 20208344, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15049826, 16014871, 16547061, 17163968, 17310068, 19648245, 20208344, 27561249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L31" /protein_id="NP_391588.1" /db_xref="EnsemblGenomes-Gn:BSU37070" /db_xref="EnsemblGenomes-Tr:CAB15724" /db_xref="GOA:Q03223" /db_xref="InterPro:IPR002150" /db_xref="InterPro:IPR027491" /db_xref="InterPro:IPR034704" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10417" /db_xref="UniProtKB/Swiss-Prot:Q03223" /translation="MKAGIHPNFKKATVKCACGNEFETGSVKEEVRVEICSECHPFYT GRQKFASADGRVDRFNKKYGLK*" /label="rpmEA CDS" gene complement(3317991..3318191) /gene="rpmEA" /locus_tag="BSU_37070" /old_locus_tag="BSU37070" /label="rpmEA gene" downshifts complement(3318004) /Source="Nicolas_upshifts" /id="D1917" /incds=0 /nref=268 /ntot=279 /MaxReadThrough="5.35148" /MaxDrop="6.82076" /score="15.63162" /energy="-10.3" /TU="U2918,U2919" /idTUdmin="U2921" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3318192..3318269) /Source="Nicolas_S_feature" /locus_tag="new_3803282_3803359_c" /HighExp="HPh, LPh, LPhT, GM 45, Paraq, MG 45, MG 60, aero, LBGexp, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.811, 1" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.997" /label="S1435" promotor_-10 complement(3318265..3318284) /Source="Nicolas_upshift_promotors" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3318269) /Source="Nicolas_upshifts" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3318298..3318305) /Source="Nicolas_upshift_promotors" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3318310..3319593) /gene="rho" /locus_tag="BSU_37080" /old_locus_tag="BSU37080" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10027981, 16014871, 18852477, 28520932, 28723971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10027981, 16014871, 18852477, 28520932, 28723971; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcriptional terminator Rho" /protein_id="NP_391589.2" /db_xref="EnsemblGenomes-Gn:BSU37080" /db_xref="EnsemblGenomes-Tr:CAB15725" /db_xref="GOA:Q03222" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004665" /db_xref="InterPro:IPR011112" /db_xref="InterPro:IPR011113" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036269" /db_xref="SubtiList:BG10416" /db_xref="UniProtKB/Swiss-Prot:Q03222" /translation="MKDVSISSLENMKLKELYELARHYKISYYSKLTKKELIFAILKA NAEQEDLLFMEGVLEIIQSEGFGFLRPINYSPSSEDIYISASQIRRFDLRNGDKVSGK VRPPKENERYYGLLHVEAVNGDDPESAKERVHFPALTPLYPDRQMVLETKPNFLSTRI MDMMAPVGFGQRGLIVAPPKAGKTMLLKEIANSITANQPEAELIVLLIDERPEEVTDI ERSVAGDVVSSTFDEVPENHIKVAELVLERAMRLVEHKKDVIILMDSITRLARAYNLV IPPSGRTLSGGIDPAAFHRPKRFFGAARNIEEGGSLTILATALVDTGSRMDDVIYEEF KGTGNMELHLDRSLAERRIFPAIDIRRSGTRKEELLVPKEHLDRLWSIRKTMSDSPDF AEKFMRKMKKTKTNQEFFDILNQEWKQANLSSARR*" /label="rho CDS" gene complement(3318310..3319593) /gene="rho" /locus_tag="BSU_37080" /old_locus_tag="BSU37080" /label="rho gene" S_feature complement(3319594..3319896) /Source="Nicolas_S_feature" /locus_tag="new_3804684_3804986_c" /HighExp="H2O2, Cold, G135, HPh, G180, G150, LBGstat, Oxctl, Paraq, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.811, 1" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.997" /label="S1436" CDS complement(3319624..3319785) /locus_tag="BSU_37089" /old_locus_tag="BSU37089" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 20525796" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514010.1" /db_xref="EnsemblGenomes-Gn:BSU37089" /db_xref="EnsemblGenomes-Tr:CCQ48606" /db_xref="UniProtKB/TrEMBL:L8EA05" /translation="MFLSSLPSKLIKTILLTKAPIMGGSVTDRSSFMLKKECALADVV QKQQMTCSE*" /label="hypothetical protein CDS" gene complement(3319624..3319785) /locus_tag="BSU_37089" /old_locus_tag="BSU37089" /label="gene" promotor_-10 complement(3319876..3319895) /Source="Nicolas_upshift_promotors" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3319896) /Source="Nicolas_upshifts" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3319911..3319915) /Source="Nicolas_upshift_promotors" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3320000..3320965) /gene="glpX" /locus_tag="BSU_37090" /old_locus_tag="BSU37090" /EC_number="3.1.3.11" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose 1,6-bisphosphatase class II" /protein_id="NP_391590.1" /db_xref="EnsemblGenomes-Gn:BSU37090" /db_xref="EnsemblGenomes-Tr:CAB15726" /db_xref="GOA:Q03224" /db_xref="InterPro:IPR004464" /db_xref="SubtiList:BG10415" /db_xref="UniProtKB/Swiss-Prot:Q03224" /translation="MERSLSMELVRVTEAAALASARWMGRGKKDEADEAATSAMRDVF DTVPMKGTVVIGEGEMDEAPMLYIGEKLGNGYGPRVDVAVDPLEGTNILASGGWNALT VIAVADHGTLLNAPDMYMQKIAVGPEAVGCIDIEAPVIDNLKAVAKAKNKDVEDVVAT ILNRERHAKIISELREAGARIKLINDGDVAGAINTAFDHTGVDILFGSGGAPEGVLSA VALKALGGEIIGKLLPQSEEEITRCHKMGLDLSKVLRMEDLVKGDDAIFAATGVTDGE LLKGVQFKGSVGTTESLVIRAKSGTVRFVDGRHSLKKKPNLVIRP*" /label="glpX CDS" gene complement(3320000..3320965) /gene="glpX" /locus_tag="BSU_37090" /old_locus_tag="BSU37090" /label="glpX gene" downshifts complement(3320006) /Source="Nicolas_upshifts" /id="D1918" /incds=0 /nref=56 /ntot=196 /MaxReadThrough="5.42698" /MaxDrop="5.21817" /score="-2.15106481" /energy="-10.2" /TU="U2921,U2922" /idTUdmin="U2922" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-35 3320582..3320591 /Source="Nicolas_upshift_promotors" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3320604..3320623 /Source="Nicolas_upshift_promotors" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3320612 /Source="Nicolas_upshifts" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3320996..3322285) /gene="murAB" /locus_tag="BSU_37100" /old_locus_tag="BSU37100" /EC_number="2.5.1.7" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14763982, 19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14763982, 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine 1-carboxyvinyltransferase" /protein_id="NP_391591.2" /db_xref="EnsemblGenomes-Gn:BSU37100" /db_xref="EnsemblGenomes-Tr:CAB15727" /db_xref="GOA:P19670" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR005750" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG10414" /db_xref="UniProtKB/Swiss-Prot:P19670" /translation="MEKLNIAGGDSLNGTVHISGAKNSAVALIPATILANSEVTIEGL PEISDIETLRDLLKEIGGNVHFENGEMVVDPTSMISMPLPNGKVKKLRASYYLMGAML GRFKQAVIGLPGGCHLGPRPIDQHIKGFEALGAEVTNEQGAIYLRAERLRGARIYLDV VSVGATINIMLAAVLAEGKTIIENAAKEPEIIDVATLLTSMGAKIKGAGTNVIRIDGV KELHGCKHTIIPDRIEAGTFMIAGAAMGKEVIIDNVIPTHLESLTAKLREMGYHIETS DDQLLIVGGQKNLKPVDVKTLVYPGFPTDLQQPMTALLTRAKGTSVVTDTIYSARFKH IDELRRMGANMKVEGRSAIITGPVELQGAKVKASDLRAGACLVVAGLMADGVTEITGL EHIDRGYSSLEKKLEGLGATIWRERMTDEEIEQLQNS*" /label="murAB CDS" gene complement(3320996..3322285) /gene="murAB" /locus_tag="BSU_37100" /old_locus_tag="BSU37100" /label="murAB gene" S_feature complement(3322286..3322645) /Source="Nicolas_S_feature" /locus_tag="new_3807376_3807735_c" /HighExp="dia5, Fru, UNK1, Glucon, HiOs, T-5.40H, nit, SMM, MG 120, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.16076699999999999" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1437" CDS complement(3322664..3323302) /gene="tal" /locus_tag="BSU_37110" /old_locus_tag="BSU37110" /EC_number="2.2.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4275311, 12469342, 22212631, 23468065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4275311, 12469342, 22212631, 23468065; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transaldolase" /protein_id="NP_391592.3" /db_xref="EnsemblGenomes-Gn:BSU37110" /db_xref="EnsemblGenomes-Tr:CAB15728" /db_xref="GOA:P19669" /db_xref="InterPro:IPR001585" /db_xref="InterPro:IPR004731" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018225" /db_xref="InterPro:IPR022999" /db_xref="InterPro:IPR033919" /db_xref="PDB:3R8R" /db_xref="SubtiList:BG10413" /db_xref="UniProtKB/Swiss-Prot:P19669" /translation="MLFFVDTANIDEIREANELGILAGVTTNPSLVAKEANVSFHDRL REITDVVKGSVSAEVISLKAEEMIEEGKELAKIAPNITVKIPMTSDGLKAVRALTDLG IKTNVTLIFNANQALLAARAGATYVSPFLGRLDDIGHNGLDLISEVKQIFDIHGLDTQ IIAASIRHPQHVTEAALRGAHIGTMPLKVIHALTKHPLTDKGIEQFLADWNK*" /label="tal CDS" gene complement(3322664..3323302) /gene="tal" /locus_tag="BSU_37110" /old_locus_tag="BSU37110" /label="tal gene" downshifts complement(3322690) /Source="Nicolas_upshifts" /id="D1919" /incds=0 /nref=6 /ntot=65 /MaxReadThrough="6.97243" /MaxDrop="4.038" /score="-6.93331064" /energy="-18.4" /TU="U2921,U2922" /idTUdmin="U2926" /TUdmin=1716 /isTUend="FALSE" /label="downshifts" S_feature complement(3323303..3323421) /Source="Nicolas_S_feature" /locus_tag="new_3808393_3808511_c" /HighExp="dia5, LBGtran, M40t45, Lbtran, Mt0, M40t90, M0t45, Lbstat, Lbexp, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1438" CDS complement(3323422..3324279) /gene="fbaA" /locus_tag="BSU_37120" /old_locus_tag="BSU37120" /EC_number="4.1.2.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559165, 10658656, 12682299, 14526031, 17420574, 18310071, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559165, 10658656, 12682299, 14526031, 17420574, 18310071, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1,6-bisphosphate aldolase" /protein_id="NP_391593.1" /db_xref="EnsemblGenomes-Gn:BSU37120" /db_xref="EnsemblGenomes-Tr:CAB15729" /db_xref="GOA:P13243" /db_xref="InterPro:IPR000771" /db_xref="InterPro:IPR011289" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG10412" /db_xref="UniProtKB/Swiss-Prot:P13243" /translation="MPLVSMTEMLNTAKEKGYAVGQFNLNNLEFTQAILQAAEEEKSP VILGVSEGAGRYMGGFKTVVAMVKALMEEYKVTVPVAIHLDHGSSFESCAKAIHAGFT SVMIDASHHPFEENVATTAKVVELAHFHGVSVEAELGTVGGQEDDVIAEGVIYADPKE CQELVERTGIDCLAPALGSVHGPYKGEPNLGFKEMEEIGKSTGLPLVLHGGTGIPTAD IKKSISLGTAKINVNTENQISSAKAVRETLAAKPDEYDPRKYLGPAREAIKETVIGKM REFGSSNQA*" /label="fbaA CDS" gene complement(3323422..3324279) /gene="fbaA" /locus_tag="BSU_37120" /old_locus_tag="BSU37120" /label="fbaA gene" S_feature complement(3324280..3324406) /Source="Nicolas_S_feature" /locus_tag="new_3809370_3809496_c" /HighExp="C90, Lbtran, LBGtran, dia5, LBGexp, aero, M0t90, Glu, Lbexp, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1439" promotor_-10 complement(3324388..3324407) /Source="Nicolas_upshift_promotors" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="promotor_-10" upshifts complement(3324406) /Source="Nicolas_upshifts" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="upshifts" promotor_-35 complement(3324421..3324428) /Source="Nicolas_upshift_promotors" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="promotor_-35" CDS complement(3324460..3324834) /gene="spo0F" /locus_tag="BSU_37130" /old_locus_tag="BSU37130" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8257105, 11934609, 16788205, 17350627, 19004019, 19040634, 20413551, 22267516, 25256619, 26055117, 27543719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8257105, 11934609, 16788205, 17350627, 19004019, 19040634, 20413551, 22267516, 25256619, 26055117, 27543719; Product type r : regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator of sporulation initiation" /protein_id="NP_391594.1" /db_xref="EnsemblGenomes-Gn:BSU37130" /db_xref="EnsemblGenomes-Tr:CAB15730" /db_xref="GOA:P06628" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="PDB:1F51" /db_xref="PDB:1FSP" /db_xref="PDB:1NAT" /db_xref="PDB:1PEY" /db_xref="PDB:1PUX" /db_xref="PDB:1SRR" /db_xref="PDB:2FSP" /db_xref="PDB:2FTK" /db_xref="PDB:2JVI" /db_xref="PDB:2JVJ" /db_xref="PDB:2JVK" /db_xref="PDB:3Q15" /db_xref="SubtiList:BG10411" /db_xref="UniProtKB/Swiss-Prot:P06628" /translation="MMNEKILIVDDQYGIRILLNEVFNKEGYQTFQAANGLQALDIVT KERPDLVLLDMKIPGMDGIEILKRMKVIDENIRVIIMTAYGELDMIQESKELGALTHF AKPFDIDEIRDAVKKYLPLKSN*" /label="spo0F CDS" gene complement(3324460..3324834) /gene="spo0F" /locus_tag="BSU_37130" /old_locus_tag="BSU37130" /label="spo0F gene" promotor_-10 complement(3324874..3324892) /Source="Nicolas_upshift_promotors" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="promotor_-10" upshifts complement(3324888) /Source="Nicolas_upshifts" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="upshifts" S_feature complement(3324890..3325529) /Source="Nicolas_S_feature" /locus_tag="new_3809980_3810619_c" /HighExp="dia15, Diami, dia5, G135, Etha, G150, G180, Salt, H2O2, Paraq" /AntisenseName="ywjG" /AntisenseCor="0.58536525532649697" /AntisenseRegPval="-25.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1440" promotor_-35 3324891..3324894 /Source="Nicolas_upshift_promotors" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3324903..3324911) /Source="Nicolas_upshift_promotors" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="promotor_-35" promotor_-10 3324910..3324929 /Source="Nicolas_upshift_promotors" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3324923 /Source="Nicolas_upshifts" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3324937..3324942 /Source="Nicolas_upshift_promotors" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3324958..3324977 /Source="Nicolas_upshift_promotors" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3324968 /Source="Nicolas_upshifts" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="upshifts" CDS 3325000..3325521 /gene="ywjG" /locus_tag="BSU_37140" /old_locus_tag="BSU37140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391595.1" /db_xref="EnsemblGenomes-Gn:BSU37140" /db_xref="EnsemblGenomes-Tr:CAB15731" /db_xref="InterPro:IPR019676" /db_xref="SubtiList:BG11053" /db_xref="UniProtKB/Swiss-Prot:P06629" /translation="MLKIFTTQLTGIFSRIQDKESDAIEDGARLLAQAVISGHSIYLY GANELQGVFYEATESKEPFPSVKAFPENAEEVTESDRVLMFCSGTGTAEEQELAKELY EKGAGVVCVSPAAKDSAGIEQYCDVHIDSKLKMPLVPDEDGTRYGFPSLMTALYVYHA LSFTLKEILQEYA*" /label="ywjG CDS" gene 3325000..3325521 /gene="ywjG" /locus_tag="BSU_37140" /old_locus_tag="BSU37140" /label="ywjG gene" promotor_-35 3325464..3325467 /Source="Nicolas_upshift_promotors" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3325482..3325501 /Source="Nicolas_upshift_promotors" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3325496 /Source="Nicolas_upshifts" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3325519..3325538) /Source="Nicolas_upshift_promotors" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="promotor_-10" upshifts complement(3325529) /Source="Nicolas_upshifts" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="upshifts" downshifts 3325540 /Source="Nicolas_upshifts" /id="D1920" /incds=0 /nref=191 /ntot=242 /MaxReadThrough="1.98527" /MaxDrop="5.8354" /score="11.5531593" /energy="-11.9" /TU="NA" /idTUdmin="U2923" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(3325553..3325560) /Source="Nicolas_upshift_promotors" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="promotor_-35" CDS complement(3325603..3327210) /gene="pyrG" /locus_tag="BSU_37150" /old_locus_tag="BSU37150" /EC_number="6.3.4.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11544212, 15252202, 17158658, 17302819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544212, 15252202, 17158658, 17302819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="CTP synthetase" /protein_id="NP_391596.1" /db_xref="EnsemblGenomes-Gn:BSU37150" /db_xref="EnsemblGenomes-Tr:CAB15743" /db_xref="GOA:P13242" /db_xref="InterPro:IPR004468" /db_xref="InterPro:IPR017456" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR033828" /db_xref="SubtiList:BG10410" /db_xref="UniProtKB/Swiss-Prot:P13242" /translation="MTKYIFVTGGVVSSLGKGIVAASLGRLLKNRGLNVTIQKFDPYI NVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFIDINLNKFSNVTTGKIYSTVLKKE RRGDYLGGTVQVIPHITNELKDRVYRAGKETNADVVITEIGGTVGDIESLPFLEAIRQ MKSDIGRENVMYIHCTLVPYIKAAGELKTKPTQHSVKELRSLGIQPNIIVVRTEMPIS QDMKDKIALFCDIDTKAVIECEDADNLYSIPLELQKQGLDKLVCEHMKLACKEAEMSE WKELVNKVSNLSQTITIGLVGKYVELPDAYISVVESLRHAGYAFDTDVKVKWINAEEV TENNIAELTSGTDGIIVPGGFGDRGVEGKIVATKYARENNIPFLGICLGMQVASIEYA RNVLGLKGAHSAEIDPSTQYPIIDLLPEQKDVEDLGGTLRLGLYPCKLEEGTKAFEVY QDEVVYERHRHRYEFNNEFRQQMEEQGFVFSGTSPDGRLVEIIELKDHPWFVASQFHP EFKSRPTRPQPLFKGFIGASVEAANQK*" /label="pyrG CDS" gene complement(3325603..3327210) /gene="pyrG" /locus_tag="BSU_37150" /old_locus_tag="BSU37150" /label="pyrG gene" downshifts complement(3325616) /Source="Nicolas_upshifts" /id="D1921" /incds=0 /nref=222 /ntot=259 /MaxReadThrough="2.2929" /MaxDrop="8.17874" /score="18.9699606" /energy="-12.1" /TU="NA" /idTUdmin="U2927" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3327211..3327398) /Source="Nicolas_S_feature" /locus_tag="new_3812301_3812488_c" /HighExp="LBGexp, Lbexp, dia0, G150, G135, G180, Paraq, Oxctl, dia15, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1441" promotor_-10 complement(3327386..3327405) /Source="Nicolas_upshift_promotors" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3327398) /Source="Nicolas_upshifts" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3327420..3327427) /Source="Nicolas_upshift_promotors" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3327452..3327973) /gene="rpoE" /locus_tag="BSU_37160" /old_locus_tag="BSU37160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:189250, 9795209, 10336502, 10438769, 10672039, 10910724, 11029421, 23543716, 26546673, 27679485" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 189250, 9795209, 10336502, 10438769, 10672039, 10910724, 11029421, 23543716, 26546673, 27679485; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase (delta subunit) and transcriptional repressor" /protein_id="NP_391597.1" /db_xref="EnsemblGenomes-Gn:BSU37160" /db_xref="EnsemblGenomes-Tr:CAB15744" /db_xref="GOA:P12464" /db_xref="InterPro:IPR007759" /db_xref="InterPro:IPR029757" /db_xref="PDB:2KRC" /db_xref="PDB:2M4K" /db_xref="PDB:4NC7" /db_xref="PDB:4NC8" /db_xref="SubtiList:BG10409" /db_xref="UniProtKB/Swiss-Prot:P12464" /translation="MGIKQYSQEELKEMALVEIAHELFEEHKKPVPFQELLNEIASLL GVKKEELGDRIAQFYTDLNIDGRFLALSDQTWGLRSWYPYDQLDEETQPTVKAKKKKA KKAVEEDLDLDEFEEIDEDDLDLDEVEEELDLEADDFDEEDLDEDDDDLEIEEDIIDE DDEDYDDEEEEIK*" /label="rpoE CDS" gene complement(3327452..3327973) /gene="rpoE" /locus_tag="BSU_37160" /old_locus_tag="BSU37160" /label="rpoE gene" downshifts complement(3327508) /Source="Nicolas_upshifts" /id="D1922" /incds=0 /nref=7 /ntot=182 /MaxReadThrough="6.49215" /MaxDrop="3.2129" /score="19.8764263" /energy="-19.4" /TU="U2928,U2929" /idTUdmin="U2927" /TUdmin="-1892" /isTUend="FALSE" /label="downshifts" S_feature complement(3327974..3328076) /Source="Nicolas_S_feature" /locus_tag="new_3813064_3813166_c" /HighExp="H2O2, Paraq, Oxctl, LBGexp, G180, dia15, dia0, Lbexp, BMM, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1442" promotor_-10 complement(3328057..3328076) /Source="Nicolas_upshift_promotors" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3328076) /Source="Nicolas_upshifts" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3328078..3328155) /Source="Nicolas_S_feature" /locus_tag="new_3813168_3813245_c" /HighExp="T0.30H, S8, S7, S6, S4, S3, S5, Sw, BC, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1443" promotor_-35 complement(3328092..3328095) /Source="Nicolas_upshift_promotors" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3328156..3329295) /gene="acdA" /locus_tag="BSU_37170" /old_locus_tag="BSU37170" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA dehydrogenase" /protein_id="NP_391598.1" /db_xref="EnsemblGenomes-Gn:BSU37170" /db_xref="EnsemblGenomes-Tr:CAB15745" /db_xref="GOA:P45867" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG11239" /db_xref="UniProtKB/Swiss-Prot:P45867" /translation="MNFSLSEEHEMIRKLVRDFAKHEVAPTAAERDEQERFDRELFRE MANLGLTGIPWPEDYGGIGSDYLAYVIAVEELSKVCASTGVTLSAHISLCSWPLFAFG TEEQKTEYLTQLALGEKIGAFALTEAGSGSDAGSMKTTAERIGDDYVLNGSKVFITNG GVADIYIVFAVTDPEKKKKGVTAFIVEKDFEGFFTGKKEKKLGIRSSPTTEIMFEDCV VPASKRLGEEGEGFKIAMKTLDGGRNGIAAQAVGIAQGALDAALQYAKERKQFGKSIA EQQGIAFKLADMATMIEASRLLTYQAAWLESSGLPYGKASAMSKLMAGDTAMKVTTEA VQIFGGYGYTKDYPVERYMRDAKITQIYEGTQEIQRLVISRMLAD*" /label="acdA CDS" gene complement(3328156..3329295) /gene="acdA" /locus_tag="BSU_37170" /old_locus_tag="BSU37170" /label="acdA gene" CDS complement(3329292..3331409) /gene="fadF" /locus_tag="BSU_37180" /old_locus_tag="BSU37180" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative iron-sulphur-binding reductase" /protein_id="NP_391599.1" /db_xref="EnsemblGenomes-Gn:BSU37180" /db_xref="EnsemblGenomes-Tr:CAB15746" /db_xref="GOA:P45866" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR036197" /db_xref="SubtiList:BG11311" /db_xref="UniProtKB/Swiss-Prot:P45866" /translation="MSGFLIANALLFLIVTAYAVYLFVYLVKTRLAYIKLGQKEQFDQ RFKERLHAIWVNVFGQKKLLKDKKSGIIHVMFFYGFILVQFGAIDFIIKGLAPGRNLS LGPVYPAFTFFQEIVTFLILIAVGWAFYRRYIEKLVRLKRGFKAGLVLIFIGGLMLTV LLGNGMNLIWHEHGLSWSEPIASGIAFMLSGVGKTGAAVIFYIAWWIHLLFLLSFLVY VPQSKHAHLIAGPANVFFNRMESAGKLEKIDFTDETKESYGAGKIEDFRQSQLLDLYA CVECGRCTNMCPATGTGKMLSPMDLILRLRDHLTEKGAAVTSRSPWVPAAAFRHTRGN QLAAASAGSGSQEAAAALDYNPSLIGDVITEEEIWACTTCRNCEDQCPVMNEHVDKII DLRRYLVLTEGKMDSDAQRAMTSIERQGNPWGLNRKERENWRDEAPDAEIPTVKEMKK EGKEFEYLFWVGSMGSYDNRSQKIAISFAKLLNHAGVSFAILGNKEKNSGDTPRRLGN EFLFQELAEKNISEFEKNDVKKIVTIDPHAYNLFKNEYPDFGFEGEVYHHTEVLAELV KNGKLRPQHPLHETITFHDSCYLGRYNEVYDPPREILKAIPGVQLVEMERSRETGMCC GAGGGLMWMEEETGNRINVARTEQALAVNPSVISSGCPYCLTMLGDGTKAKEAEDQVK TYDVVELLAQSVLGADLKMGEKQ*" /label="fadF CDS" gene complement(3329292..3331409) /gene="fadF" /locus_tag="BSU_37180" /old_locus_tag="BSU37180" /label="fadF gene" S_feature complement(3331410..3331468) /Source="Nicolas_S_feature" /locus_tag="new_3816500_3816558_c" /HighExp="T0.30H, S6, BC, S8, S7, Sw, S5, S4, Lbstat, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1444" promotor_-10 complement(3331469..3331488) /Source="Nicolas_upshift_promotors" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3331482) /Source="Nicolas_upshifts" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3331502..3331509) /Source="Nicolas_upshift_promotors" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3331508..3331514 /Source="Nicolas_upshift_promotors" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3331528..3331539 /Source="Nicolas_upshift_promotors" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3331533 /Source="Nicolas_upshifts" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="upshifts" CDS 3331564..3332760 /gene="clsB" /locus_tag="BSU_37190" /old_locus_tag="BSU37190" /EC_number="2.7.8.-" /function="16.8: Protect" /function="16.13: Shape" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14973018, 16514141, 18820022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973018, 16514141, 18820022; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor cardiolipin synthetase (phospholipase D family)" /protein_id="NP_391600.1" /db_xref="EnsemblGenomes-Gn:BSU37190" /db_xref="EnsemblGenomes-Tr:CAB15747" /db_xref="GOA:P45865" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="SubtiList:BG11310" /db_xref="UniProtKB/Swiss-Prot:P45865" /translation="MKVFIVIMIIVVIFFALILLDIFMGRAGYRKKAYEPVFSKKKSD IELIHCGADLVERMMNDIRQAASSVHMMFFIMKNDEVSHNMYTLLKTKAQAGVSVYLL LDWAGCRAIKKTALQTMKNAGVHVHVMNRPRFPFFFFHMQKRNHRKITVIDGKIGYIG GFNIAEEYLGKKAKFGNWEDYHLRMIGEGVHDLQTLFASDLKRNTGIELGSDVWPKLQ QGTISHKIYATDGYSLENIYLANIAQAKNRLTVCTPYYIPSKPLQEALINARKNGVSV RIIVPMKSDHPLVREAAFTYYSELLDAGCLIYRYYQGFYHVKALIIDDHLSIIGTANF DKRSLFLNEEVNVEIDDEAFTSEVYATIEEDMKKSELLTMEDFSKRTFRQRPAEWLGR ALSYFL*" /label="clsB CDS" gene 3331564..3332760 /gene="clsB" /locus_tag="BSU_37190" /old_locus_tag="BSU37190" /label="clsB gene" S_feature complement(3331756..3332634) /Source="Nicolas_S_feature" /locus_tag="new_3816846_3817724_c" /HighExp="S4, S5, S3, S6, S7, S8, BT, B36, LoTm, B60" /AntisenseName="clsB" /AntisenseCor="0.84883232203587" /AntisenseRegPval="-75.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1445" promotor_-10 complement(3332624..3332642) /Source="Nicolas_upshift_promotors" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3332635) /Source="Nicolas_upshifts" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3332658..3332663) /Source="Nicolas_upshift_promotors" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3332773..3333735 /gene="uvsE" /locus_tag="BSU_37200" /old_locus_tag="BSU37200" /EC_number="3.-.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8614629, 22961846" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8614629, 22961846; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UV DNA damage repair endonuclease" /protein_id="NP_391601.1" /db_xref="EnsemblGenomes-Gn:BSU37200" /db_xref="EnsemblGenomes-Tr:CAB15748" /db_xref="GOA:P45864" /db_xref="InterPro:IPR004601" /db_xref="InterPro:IPR023520" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11309" /db_xref="UniProtKB/Swiss-Prot:P45864" /translation="MIFRFGFVSNAMSLWDASPAKTLTFARYSKLSKTERKEALLTVT KANLRNTMRTLHYIIGHGIPLYRFSSSIVPLATHPDVMWDFVTPFQKEFREIGELVKT HQLRTSFHPNQFTLFTSPKESVTKNAVTDMAYHYRMLEAMGIADRSVINIHIGGAYGN KDTATAQFHQNIKQLPQEIKERMTLENDDKTYTTEETLQVCEQEDVPFVFDFHHFYAN PDDHADLNVALPRMIKTWERIGLQPKVHLSSPKSEQAIRSHADYVDANFLLPLLERFR QWGTNIDFMIEAKQKDKALLRLMDELSSIRGVKRIGGGALQWKS*" /label="uvsE CDS" gene 3332773..3333735 /gene="uvsE" /locus_tag="BSU_37200" /old_locus_tag="BSU37200" /label="uvsE gene" promotor_-35 3333749..3333755 /Source="Nicolas_upshift_promotors" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3333770..3333788 /Source="Nicolas_upshift_promotors" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3333770 /Source="Nicolas_upshifts" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="upshifts" CDS 3333816..3334088 /gene="ywjC" /locus_tag="BSU_37210" /old_locus_tag="BSU37210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391602.1" /db_xref="EnsemblGenomes-Gn:BSU37210" /db_xref="EnsemblGenomes-Tr:CAB15749" /db_xref="InterPro:IPR035895" /db_xref="SubtiList:BG11308" /db_xref="UniProtKB/Swiss-Prot:P45863" /translation="MKNIKSLKVAAQAFTLRNLIHLYKMCHSGSHEVYIYSKKTMCKI KSLIELETFRMAHNEKEYLIVVEGTKASQLIEKFQNLIEPAEREAL*" /label="ywjC CDS" gene 3333816..3334088 /gene="ywjC" /locus_tag="BSU_37210" /old_locus_tag="BSU37210" /label="ywjC gene" downshifts complement(3333822) /Source="Nicolas_upshifts" /id="D1923" /incds=0 /nref=4 /ntot=17 /MaxReadThrough="1.03516" /MaxDrop="5.08765" /score="17.8471239" /energy="-10" /TU="NA" /idTUdmin="U2933" /TUdmin=330 /isTUend="FALSE" /label="downshifts" downshifts 3334078 /Source="Nicolas_upshifts" /id="D1924" /incds=0 /nref=54 /ntot=128 /MaxReadThrough="4.49396" /MaxDrop="7.49636" /score="14.0189582" /energy="-10" /TU="U2932" /idTUdmin="U2930" /TUdmin=178 /isTUend="FALSE" /label="downshifts" S_feature 3334123..3334529 /Source="Nicolas_S_feature" /locus_tag="new_3819213_3819619" /HighExp="Etha, C30, Sw, Gly, C90, M/G, BC, Salt, Fru, G135" /AntisenseName="ywjB" /AntisenseCor="0.2646821361217" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1446" CDS complement(3334130..3334654) /gene="ywjB" /locus_tag="BSU_37220" /old_locus_tag="BSU37220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12354229, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391603.1" /db_xref="EnsemblGenomes-Gn:BSU37220" /db_xref="EnsemblGenomes-Tr:CAB15750" /db_xref="GOA:P45862" /db_xref="InterPro:IPR002734" /db_xref="InterPro:IPR024072" /db_xref="SubtiList:BG11307" /db_xref="UniProtKB/Swiss-Prot:P45862" /translation="MERKTVLYIAVSLDGMIAKEDGSIDWLDEFEGEGDNGYSDFYQT VDTVILGRSTYEHVKVLTPVFPYQDKTCYVFTGSPDSYQDEHVTFINEGARAFTARLK QEKGSNIWIAGGAELVNDFMKEDAIDEFIITVIPVVLGSGIPLFHELTNETKLRLKGT KQFGQAVQLHYVRA*" /label="ywjB CDS" gene complement(3334130..3334654) /gene="ywjB" /locus_tag="BSU_37220" /old_locus_tag="BSU37220" /label="ywjB gene" downshifts complement(3334152) /Source="Nicolas_upshifts" /id="D1925" /incds=0 /nref=194 /ntot=239 /MaxReadThrough="1.38978" /MaxDrop="6.19859" /score="17.8471239" /energy="-10" /TU="NA" /idTUdmin="U2933" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3334664..3336391) /gene="ywjA" /locus_tag="BSU_37230" /old_locus_tag="BSU37230" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12119303, 12354229, 25652542; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC lipid transporter (ATP-binding protein)" /protein_id="NP_391604.1" /db_xref="EnsemblGenomes-Gn:BSU37230" /db_xref="EnsemblGenomes-Tr:CAB15751" /db_xref="GOA:P45861" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11306" /db_xref="UniProtKB/Swiss-Prot:P45861" /translation="MLRQFFSYYKPYKTLFFLDFFSAIAGGLMELSFPLIVNYFIDTL LPGRDWGLIIATSIGLFAVYALSSALQYIVTYWGHMLGINIETDMRKSLFDHLQKLSF KFYDNNKTGTLMSKLTNDLMYIGEVAHHGPEDLFIAVMTILGAFGVMLFINWQLALLT FIIMPIVIWLALYFNKKMTKAFTTLNKDIGDFSARVENNIGGIRLVQAFGNEAFEKER FAVNNQRFRVTKLSSYKIMAKNGSISYMLTRFVTLFVLLCGTWFVIRGSLSYGEFVAF VLLTNVLFRPIDKINAIIEMYPRGIAGFKSYMELMETEPDIQDSPDSKDVSGLKGNIR YKHVSFGYDDHHNVLNDINLSIQAGETVAFVGPSGAGKSTLCSLLPRFYEASEGDITI DGISIKDMTLSSLRGQIGVVQQDVFLFSGTLRENIAYGRLGASEEDIWQAVKQAHLEE LVHNMPDGLDTMIGERGVKLSGGQKQRLSIARMFLKNPSILILDEATSALDTETEAAI QKALQELSEGRTTLVIAHRLATIKDADRIVVVTNNGIEEQGRHQDLIEAGGLYSRLHQ AQFGQMVHR*" /label="ywjA CDS" gene complement(3334664..3336391) /gene="ywjA" /locus_tag="BSU_37230" /old_locus_tag="BSU37230" /label="ywjA gene" promotor_-10 complement(3336425..3336444) /Source="Nicolas_upshift_promotors" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3336439) /Source="Nicolas_upshifts" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3336458..3336464) /Source="Nicolas_upshift_promotors" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3336480..3337982) /gene="clsC" /locus_tag="BSU_37240" /old_locus_tag="BSU37240" /EC_number="2.7.8.-" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14973018, 15743965, 16514141, 26025016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor cardiolipin synthetase" /protein_id="NP_391605.1" /db_xref="EnsemblGenomes-Gn:BSU37240" /db_xref="EnsemblGenomes-Tr:CAB15752" /db_xref="GOA:P45860" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="InterPro:IPR027379" /db_xref="InterPro:IPR030874" /db_xref="SubtiList:BG11305" /db_xref="UniProtKB/Swiss-Prot:P45860" /translation="MLKRRLEFFFLYMMLIGAYVIWFFPVSRLEFYGGLLCYISIILF SIYSLILENRTSQHTLLWIHILVFFPIVGYVFYLFSGQLYVKGKLFKTKRMYNREKLR KLFDKEETPEVTGLKDNQERFFTYSIRAAHMNINTKSNIKVLKNGEETFPDIFKAMRK AESYIHIEYYMFKSDMLGRGMMDIMMEKARQGVEVRFLYDAAGSMKLARRDIMRMKQA GVDIVPFSPLKYGFFNQKLNFRNHRKIVIIDGKTGFVGGLNVGKEYISRDPYIGFWRD THLRLEGEIVQTLHAIFMLDWEYVSNEVLIDQEEYNTPVPVEGGGIYQIVATGPDMKE SMSDLYYEMISSAQKSIWIATPYFVPNESIRTALKAAATKGVEVRVMVPEKNDSFLTQ YASRSYFPELLLEGIEVYSYQKGFMHQKVMIIDGDLASVGTANMDMRSFQLNFEVNVF FTDAEAIRTLEAHFEEDMQESEKLSPVGFYKRGVADRTKESFARLFSGVL*" /label="clsC CDS" gene complement(3336480..3337982) /gene="clsC" /locus_tag="BSU_37240" /old_locus_tag="BSU37240" /label="clsC gene" promotor_-10 complement(3338006..3338024) /Source="Nicolas_upshift_promotors" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3338024) /Source="Nicolas_upshifts" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3338039..3338045) /Source="Nicolas_upshift_promotors" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3338069..3338441) /Source="Nicolas_S_feature" /locus_tag="new_3823159_3823531_c" /HighExp="Lbtran, M40t45, nit, LBGtran, LBGstat, S0, ferm, M0t45, Lbstat, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.30294500000000002" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S1447" downshifts complement(3338112) /Source="Nicolas_upshifts" /id="D1926" /incds=0 /nref=4 /ntot=19 /MaxReadThrough="2.94229" /MaxDrop="4.09744" /score="13.5274489" /energy="-11.4" /TU="NA" /idTUdmin="U2935" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3338468..3339139) /gene="narI" /locus_tag="BSU_37250" /old_locus_tag="BSU37250" /EC_number="1.7.99.4" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (gamma subunit)" /protein_id="NP_391606.1" /db_xref="EnsemblGenomes-Gn:BSU37250" /db_xref="EnsemblGenomes-Tr:CAB15753" /db_xref="GOA:P42177" /db_xref="InterPro:IPR003816" /db_xref="InterPro:IPR023234" /db_xref="InterPro:IPR036197" /db_xref="SubtiList:BG11084" /db_xref="UniProtKB/Swiss-Prot:P42177" /translation="MSGQILWGIMPYIVLTIFIGGHIYRYQHDQFGWTAKSSELLEKK KLAAGSTLFHWGLLCVVGGHVMGILIPEGVYASLGISEHMYHKMAIGAGLPAGIAACT GLVILTYRRLFDKRIRKTSSPSDILTLLLLLFMMLSGVAATFLNIDSKGFDYRTTVGP WFREIVLFRPDASLMESVPLWFKFHIVIGYVVFILWPFTRLVHVFSLPLKYLTRSYVV YRKRS*" /label="narI CDS" gene complement(3338468..3339139) /gene="narI" /locus_tag="BSU_37250" /old_locus_tag="BSU37250" /label="narI gene" downshifts complement(3338486) /Source="Nicolas_upshifts" /id="D1927" /incds=0 /nref=4 /ntot=13 /MaxReadThrough="6.70789" /MaxDrop="4.50566" /score="27.8375931" /energy="-11.7" /TU="U2935" /idTUdmin="U2935" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS complement(3339136..3339690) /gene="narJ" /locus_tag="BSU_37260" /old_locus_tag="BSU37260" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase molybdenum cofactor assembly chaperone NarJ" /protein_id="NP_391607.1" /db_xref="EnsemblGenomes-Gn:BSU37260" /db_xref="EnsemblGenomes-Tr:CAB15754" /db_xref="GOA:P42178" /db_xref="InterPro:IPR003765" /db_xref="InterPro:IPR020945" /db_xref="InterPro:IPR036411" /db_xref="SubtiList:BG11083" /db_xref="UniProtKB/Swiss-Prot:P42178" /translation="MNTTDRQITFSALSCLLSYPDEEWRAELPDWKALIQEIGNRQIR EKLLHFFETSASYSPEALIEHYVYTFDFGKKTNMYVTYFNSGEQRERGIELLHLKNTY EQSGFLPTEKELPDYLPLMLEFAAAAEIEAARSVFEKYLSNVRELASRLEKNDSIYAE LLHVLLAALENIGVRESVEGAVQA*" /label="narJ CDS" gene complement(3339136..3339690) /gene="narJ" /locus_tag="BSU_37260" /old_locus_tag="BSU37260" /label="narJ gene" CDS complement(3339716..3341179) /gene="narH" /locus_tag="BSU_37270" /old_locus_tag="BSU37270" /EC_number="1.7.99.4" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (beta subunit)" /protein_id="NP_391608.1" /db_xref="EnsemblGenomes-Gn:BSU37270" /db_xref="EnsemblGenomes-Tr:CAB15755" /db_xref="GOA:P42176" /db_xref="InterPro:IPR006547" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR029263" /db_xref="SubtiList:BG11082" /db_xref="UniProtKB/Swiss-Prot:P42176" /translation="MKIKAQIGMVMNLDKCIGCHTCSVTCKNTWTNRSGAEYMYFNNV ETKPGIGYPKQWEDQDKYKGGWTLKKGKLELKSGSKTNRLAGLFYNPNQPSIDDYYEP WNYDYETLTNSPQKKHQPVARPKSSLTGDFMNIEWGPNWEDDLAGGHITGLEDPNVQK MEESIKTEFDDVFMMYLPRICEHCINPACVSSCPSGAMYKREEDGIVLVDQNACRSWR YCVSSCPYKKVYFNWQTNKAEKCTLCFPRLEAGLPTICSETCVGRIRYLGVMLYDADK VEEAASVENEKDLYHSQLDVFLDPNDPEVAKLAKEQGIPAEWIEAAQQSPIYKMIIDW KIALPLHPEYRTLPMVWYIPPLSPIMNLFEGKGSRQTAEDIFPAIDQMRIPIDYLAQL LTAGDTDHIRSTLKKMSVMRQYMRAVQTNKSIDPELISSVGLTEQQIEDMYRLLAIAK YDDRFVIPSSHREEVSDLYAEQGSCGLSFSGGPGSCF*" /label="narH CDS" gene complement(3339716..3341179) /gene="narH" /locus_tag="BSU_37270" /old_locus_tag="BSU37270" /label="narH gene" CDS complement(3341169..3344855) /gene="narG" /locus_tag="BSU_37280" /old_locus_tag="BSU37280" /EC_number="1.7.5.1" /EC_number="1.7.99.4" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11289299, 7557333, 7860592, 8846791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (alpha subunit)" /protein_id="NP_391609.2" /db_xref="EnsemblGenomes-Gn:BSU37280" /db_xref="EnsemblGenomes-Tr:CAB15756" /db_xref="GOA:P42175" /db_xref="InterPro:IPR006468" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR027467" /db_xref="InterPro:IPR028189" /db_xref="SubtiList:BG11081" /db_xref="UniProtKB/Swiss-Prot:P42175" /translation="MKKKKRSPLFRRLNYFSPIEHHSNKHSQTTREDRDWENVYRNRW QYDKVVRSTHGVNCTGSCSWNIYVKNGIVTWEGQNLNYPSTGPDMPDFEPRGCPRGAS FSWYIYSPLRVKYPYVRGVLINLWREALQTHQNPLEAWKSIVENPEKAKSYKQARGKG GFVRAEWPEVLKLISASLLYTVMKYGPDRNVGFSPIPAMSMISHASGSRFMSLIGGPM LSFYDWYADLPPASPQIWGDQTDVPESSDWYNSGYIITWGSNVPLTRTPDAHFLAEAR YKGAKVISISPDFAESSKFADDWLSIRQGTDGALAMAMGHVILQEFYVNQETERFIEY AKQYTDFPFLVTLSKENGVYTAGRFLHAKDIGRKTKHDQWKPAVWDEQTSSFAIPQGT MGSRWDGQQKWNLHMIDEETGEPIEPRLSVLGIEDEIGTVRIPYFSNDGNKVLERDLP IKKMNLNGEETYITTVFDLILANYGVNRGIGERSAVSYDDPEPFTPAWQEQMTGIKKE AVVKIAREFAQNAIDTDGRSMIIVGAGINHWFNSDTIYRAVLNLVLLVGAQGVNGGGW AHYVGQEKLRPAEGWQTIATAKDWEGVPKLQNGTSFFYFATDQWRYEDQPISDLASPI AASSRYKHHADYNVLAARLGWLPSYPTFNQNGIDLYKEAEKAGAATPEDVGAYVASQL QEKKLKFAIEDPDNEVNFPRNLFVWRANLISSSGKGHEYFLKHLLGTTNGLMNDDSDS IRPEEIKWREQAPEGKLDLLINLDFRMAGTALYSDIVLPAATWYEKHDLSSTDMHPFI HPFAPAISAPWESKSDWDIFKALSKAVSDLAEEVDMEPVKEVVATPLLHDTMQELAQP FGKINDWSKGECEAIPGKTMPNIQVVERDYKHIFHKMTALGPNVALKPSGTKGMSWSI ADEYESLKQRLGEITSDSVAKGCPNISEAKQAAEAILTLSSTSNGKVAVKAWESLENI TNLKLKDLAEEREEECFTFEQITAQPKTVITSPAFTGSEKGGRRYSPFTTNVEKLIPW RTLTGRQSYYVDHELMMEFGETMATFKPILQHRPFLSKRPDQEGKEIVLNYLTPHNKW SVHSMYFDSLPMLTLFRGGPTVWMNKDDAEDTDIKDNDWIECFNRNGVVVARAVLSHR IPKGMAFMHHAQDRHINVPGTKLTNNRGGTHNSPTRIHVKPTQMIGGYAQLSYGFNYY GPTGNQRDLNVVIRKLKEVDWLED*" /label="narG CDS" gene complement(3341169..3344855) /gene="narG" /locus_tag="BSU_37280" /old_locus_tag="BSU37280" /label="narG gene" misc_feature complement(3344886..3344905) /Source="Nicolas_upshift_promotors" /id="U2935" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig="0.993006993006993" /xcortree=1614 /SigmaFactorBS="ctttgtgtgaacattttgtgaaaaaagcagagtgtgtgacat agttcacaaggaaacacgctgtcTCTGTTTATAGTGAACTTAGcatcacctgactcgg a" /listShort="narG, narH, narJ, narI, S1447" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3344910) /Source="Nicolas_upshifts" /id="U2935" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig="0.993006993006993" /xcortree=1614 /SigmaFactorBS="ctttgtgtgaacattttgtgaaaaaagcagagtgtgtgacat agttcacaaggaaacacgctgtcTCTGTTTATAGTGAACTTAGcatcacctgactcgg a" /listShort="narG, narH, narJ, narI, S1447" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3344912..3345041) /Source="Nicolas_S_feature" /locus_tag="new_3830002_3830131_c" /HighExp="Lbtran, M40t45, LBGtran, ferm, M0t45, nit, S0, Lbstat, LBGstat, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1448" CDS complement(3345051..3345527) /gene="arfM" /locus_tag="BSU_37290" /old_locus_tag="BSU37290" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10809684, 11698370, 16428414, 22178965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 11698370, 16428414, 22178965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_391610.1" /db_xref="EnsemblGenomes-Gn:BSU37290" /db_xref="EnsemblGenomes-Tr:CAB15757" /db_xref="GOA:P46910" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018490" /db_xref="SubtiList:BG11345" /db_xref="UniProtKB/Swiss-Prot:P46910" /translation="MNQCDYLLFLKQLPMFNEVPLSIVETLLKNGTFIRGSCDQSPSF LHSQSVYIVLKGSVRFMDTRLPEGSKTVALWEKGDVFPIDEKGGLYLSPFISVNATSD ILILNIPYYIFKKMMSYHPQLQMNFLAMLQQNVFCSYQLFLRYLHTSQDENAEPGS*" /label="arfM CDS" gene complement(3345051..3345527) /gene="arfM" /locus_tag="BSU_37290" /old_locus_tag="BSU37290" /label="arfM gene" downshifts complement(3345086) /Source="Nicolas_upshifts" /id="D1928" /incds=0 /nref=10 /ntot=39 /MaxReadThrough="5.03469" /MaxDrop="3.83412" /score="30.7487171" /energy="-10.5" /TU="U2936" /idTUdmin="U2936" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3345550..3345569) /Source="Nicolas_upshift_promotors" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="promotor_-10" upshifts complement(3345562) /Source="Nicolas_upshifts" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="upshifts" promotor_-35 complement(3345584..3345587) /Source="Nicolas_upshift_promotors" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="promotor_-35" upshifts 3345634 /Source="Nicolas_upshifts" /id="U2937" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=1612 /SigmaFactorBS="gcctgtacagcagtgatgtatttcacagcctgtatgatgaat gtcacttatcaggagggtgaaTGCATTTATAATGAAAGAAAaaaggaggatttcgatg a" /listShort="ywiC" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3345637..3345656 /Source="Nicolas_upshift_promotors" /id="U2937" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=1612 /SigmaFactorBS="gcctgtacagcagtgatgtatttcacagcctgtatgatgaat gtcacttatcaggagggtgaaTGCATTTATAATGAAAGAAAaaaggaggatttcgatg a" /listShort="ywiC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3345671..3346390 /gene="ywiC" /locus_tag="BSU_37300" /old_locus_tag="BSU37300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16428414, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391611.1" /db_xref="EnsemblGenomes-Gn:BSU37300" /db_xref="EnsemblGenomes-Tr:CAB15758" /db_xref="GOA:P46909" /db_xref="InterPro:IPR025576" /db_xref="SubtiList:BG11344" /db_xref="UniProtKB/Swiss-Prot:P46909" /translation="MKALIPKQHGAWAMLLIPFLLGMVKGGPVIWHIPLFLGWLFLYL AVYPVTLALKKKQSKPYQKWMCYYGFPTCCFLMISVFHKPPLIWVGVSLLPLFLIHMY FARRKNERALLNDVAGVLFFCSGGFASCWLGMGTLDGWAWFIFLQSALFFIGSSFYVK SVIRERKNRAFAYWSWGYHLLLPFLSALFGAGWAFLAFIPSSLRAWFFHGRDWPVKTI GILEIVNACFFLAVMCLFITR*" /label="ywiC CDS" gene 3345671..3346390 /gene="ywiC" /locus_tag="BSU_37300" /old_locus_tag="BSU37300" /label="ywiC gene" downshifts 3346374 /Source="Nicolas_upshifts" /id="D1929" /incds=0 /nref=14 /ntot=34 /MaxReadThrough="2.00369" /MaxDrop="5.63285" /score="-3.54009378" /energy="-5.8" /TU="NA" /idTUdmin="U2937" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3346422..3347138) /gene="fnr" /locus_tag="BSU_37310" /old_locus_tag="BSU37310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8682783, 8846791, 16796679, 21068385, 23046954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8682783, 8846791, 16796679, 21068385, 23046954; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of anaerobic metabolism (FNR/CAP family)" /protein_id="NP_391612.1" /db_xref="EnsemblGenomes-Gn:BSU37310" /db_xref="EnsemblGenomes-Tr:CAB15759" /db_xref="GOA:P46908" /db_xref="InterPro:IPR000595" /db_xref="InterPro:IPR012318" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018335" /db_xref="InterPro:IPR018490" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11343" /db_xref="UniProtKB/Swiss-Prot:P46908" /translation="MNFLSVRPSDSDLISSDLYELLESISTKRKMEKHTYLFREGMDA EELYLIQSGLIEIGKLTSDGKDLTLRICQKHDIVGELTLFTEEPRYMLSAKVLEDGEV LVINKNKLEKELIQNGALTFEFMKWMSTHLRKIQSKIRDLLLHGKKGALYSTLIRLSN SYGVERSDGILINIVLTNQDLAKFCAAARESVNRMLGDLRKKGVISIDESGKIILHKR DYLRCEIECENCPLEICNID*" /label="fnr CDS" gene complement(3346422..3347138) /gene="fnr" /locus_tag="BSU_37310" /old_locus_tag="BSU37310" /label="fnr gene" downshifts complement(3346424) /Source="Nicolas_upshifts" /id="D1930" /incds=0 /nref=116 /ntot=238 /MaxReadThrough="3.06242" /MaxDrop="8.21489" /score="-2.80152808" /energy="-5.8" /TU="U2938,U2939" /idTUdmin="U2939" /TUdmin="-84" /isTUend="FALSE" /label="downshifts" downshifts complement(3346494) /Source="Nicolas_upshifts" /id="D1931" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="8.51297" /MaxDrop="3.71248" /score="-2.80152808" /energy="-5.8" /TU="U2938,U2939" /idTUdmin="U2939" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" misc_feature complement(3347164..3347183) /Source="Nicolas_upshift_promotors" /id="U2938" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=1623 /SigmaFactorBS="cactggggcattcacaagattgttagttttttctcgatgggt acaaatcaattCACGTTACAATAAACACACAacgtgactttcttcgaggtgagctcat g" /listShort="fnr" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3347176) /Source="Nicolas_upshifts" /id="U2938" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=1623 /SigmaFactorBS="cactggggcattcacaagattgttagttttttctcgatgggt acaaatcaattCACGTTACAATAAACACACAacgtgactttcttcgaggtgagctcat g" /listShort="fnr" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3347237..3348424) /gene="narK" /locus_tag="BSU_37320" /old_locus_tag="BSU37320" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8682783, 8846791, 15849754, 16796679, 16850406, 26786044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8682783, 8846791, 15849754, 16796679, 16850406, 26786044; Product type t : transporter" /codon_start=1 /transl_table=11 /product="nitrite extrusion permease" /protein_id="NP_391613.2" /db_xref="EnsemblGenomes-Gn:BSU37320" /db_xref="EnsemblGenomes-Tr:CAB15760" /db_xref="GOA:P46907" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11342" /db_xref="UniProtKB/Swiss-Prot:P46907" /translation="MINRQHIQLSLQSLSLVAGFMVWVLISSLISQITLDIHLSKGEI SLVTAIPVILGSLLRIPLGYLTNRFGARLMFMVSFILLLFPVFWISIADSLFDLIAGG FFLGIGGAVFSIGVTSLPKYYPKEKHGVVNGIYGAGNIGTAVTTFAAPVIAQAVGWKS TVQMYLILLAVFALLHVLFGDRHEKKVKVSVKTQIKAVYRNHVLWFLSLFYFITFGAF VAFTIYLPNFLVEHFGLNPADAGLRTAGFIAVSTLLRPAGGFLADKMSPLRILMFVFA GLTLSGIILSFSPTIGLYTFGSLTVAVCSGIGNGTVFKLVPFYFSKQAGIANGIVSAM GGLGGFFPPLILASVFQATGQYAIGFMALSEVALASFVLVIWMYWQERMKTHTERNSQ SIN*" /label="narK CDS" gene complement(3347237..3348424) /gene="narK" /locus_tag="BSU_37320" /old_locus_tag="BSU37320" /label="narK gene" misc_feature complement(3348454..3348473) /Source="Nicolas_upshift_promotors" /id="U2939" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.982017982017982" /psig="0.998001998001998" /xcortree=1615 /SigmaFactorBS="gctttgtcctttttttatgagaaaaacgtgtgatgtaattca caatcctgtttggctagTTTTTGTATGATAAGACTGAttattgaatcattgaaagggg c" /listShort="narK, fnr" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3348472) /Source="Nicolas_upshifts" /id="U2939" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.982017982017982" /psig="0.998001998001998" /xcortree=1615 /SigmaFactorBS="gctttgtcctttttttatgagaaaaacgtgtgatgtaattca caatcctgtttggctagTTTTTGTATGATAAGACTGAttattgaatcattgaaagggg c" /listShort="narK, fnr" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3348560..3350230) /gene="argS" /locus_tag="BSU_37330" /old_locus_tag="BSU37330" /EC_number="6.1.1.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8289305, 9862121" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8289305, 9862121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginyl-tRNA synthetase" /protein_id="NP_391614.1" /db_xref="EnsemblGenomes-Gn:BSU37330" /db_xref="EnsemblGenomes-Tr:CAB15761" /db_xref="GOA:P46906" /db_xref="InterPro:IPR001278" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR005148" /db_xref="InterPro:IPR008909" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR035684" /db_xref="InterPro:IPR036695" /db_xref="SubtiList:BG11341" /db_xref="UniProtKB/Swiss-Prot:P46906" /translation="MNIAEQMKDVLKEEIKAAVLKAGLAEESQIPNVVLETPKDKTHG DYSTNMAMQLARVAKKAPRQIAEEIVAHFDKGKASIEKLDIAGPGFINFYMNNQYLTK LIPSVLEAGEAYGETNIGNGERVQVEFVSANPTGDLHLGHARGAAVGDSLCNVLSKAG YDVSREYYINDAGNQINNLALSVEVRYFEALGLEKPMPEDGYRGEDIIAIGKRLAEEY GDRFVNEEESERLAFFREYGLKYELEKLRKDLENFRVPFDVWYSETSLYQNGKIDKAL EALREKGHVYEEDGATWFRSTTFGDDKDRVLIKKDGTYTYLLPDIAYHKDKLDRGFDK LINVWGADHHGYIPRMKAAIEALGYEKGTLEVEIIQLVHLYKNGEKMKMSKRTGKAVT MRDLIEEVGLDAVRYFFAMRSADTHMDFDLDLAVSTSNENPVYYAQYAHARICSMLRQ GEEQGLKPAADLDFSHIQSEKEYDLLKTIGGFPEAVAEAAEKRIPHRVTNYIYDLASA LHSFYNAEKVIDPENEEKSRARLALMKATQITLNNALQLIGVSAPEKM*" /label="argS CDS" gene complement(3348560..3350230) /gene="argS" /locus_tag="BSU_37330" /old_locus_tag="BSU37330" /label="argS gene" downshifts complement(3348562) /Source="Nicolas_upshifts" /id="D1932" /incds=0 /nref=252 /ntot=266 /MaxReadThrough="1.71727" /MaxDrop="6.56513" /score="23.3947976" /energy="-12.5" /TU="NA" /idTUdmin="U2941" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3350227..3350655) /gene="ywiB" /locus_tag="BSU_37340" /old_locus_tag="BSU37340" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative RNA binding protein" /protein_id="NP_391615.1" /db_xref="EnsemblGenomes-Gn:BSU37340" /db_xref="EnsemblGenomes-Tr:CAB15762" /db_xref="InterPro:IPR012674" /db_xref="InterPro:IPR015231" /db_xref="PDB:1R0U" /db_xref="SubtiList:BG14161" /db_xref="UniProtKB/Swiss-Prot:O07624" /translation="MKQETPITLHVKSVIEDDGNQEVIEFRTTGFYYVKQNKVYLSYY EEHDLGKVKTIVKVSEGEVLVMRSGAVKMNQRFVTGASTIAKYKMSFGELELKTSTKS IQSDLDEEKGRISIAYDMHVGDEQEHLHNMTITYEGGTHA*" /label="ywiB CDS" gene complement(3350227..3350655) /gene="ywiB" /locus_tag="BSU_37340" /old_locus_tag="BSU37340" /label="ywiB gene" misc_feature 3350723..3350737 /Source="Nicolas_upshift_promotors" /id="U2940" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.911088911088911" /psig="0.056943056943057" /xcortree=297 /SigmaFactorBS="ttcatcattccactttgacttgaatagtataatcattcggtt tgtaaacttcaACTGCTTCTATCTTAccatcattgctcatcagatttgaagataaacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3350723..3350742) /Source="Nicolas_upshift_promotors" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3350730 /Source="Nicolas_upshifts" /id="U2940" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.911088911088911" /psig="0.056943056943057" /xcortree=297 /SigmaFactorBS="ttcatcattccactttgacttgaatagtataatcattcggtt tgtaaacttcaACTGCTTCTATCTTAccatcattgctcatcagatttgaagataaacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3350739) /Source="Nicolas_upshifts" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3350759..3350762) /Source="Nicolas_upshift_promotors" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3350794..3350813) /Source="Nicolas_upshift_promotors" /id="U2942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.802197802197802" /psig="0.932067932067932" /xcortree=1621 /SigmaFactorBS="gtgaaaaggaaatgatagatttcggaaaaatgtaacatttcc taaaggtaattAGTGATATGATTTTCTCTTCtatataaggaaatgctttttatgaggt t" /GFF_Attribute="listShort" /listLong="ywiB, argS" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3350806) /Source="Nicolas_upshifts" /id="U2942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.802197802197802" /psig="0.932067932067932" /xcortree=1621 /SigmaFactorBS="gtgaaaaggaaatgatagatttcggaaaaatgtaacatttcc taaaggtaattAGTGATATGATTTTCTCTTCtatataaggaaatgctttttatgaggt t" /GFF_Attribute="listShort" /listLong="ywiB, argS" /label="upshifts" SCAR join(3350835,3350842) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs09" N_region 3350836..3350841 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs09" S_feature <3350842..3353320 /Source="Nicolas_S_feature" /locus_tag="new_3842996_3845478" /HighExp="Lbstat, nit, ferm, BI, M0t90, S2, M40t90, BT, M0t45, GM 150" /AntisenseName="ywhL" /AntisenseCor="7.7827453562424306E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.99, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1450" CDS complement(3350843..3352219) /gene="ywhL" /locus_tag="BSU_37440" /old_locus_tag="BSU37440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12073041" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391624.1" /db_xref="EnsemblGenomes-Gn:BSU37440" /db_xref="EnsemblGenomes-Tr:CAB15771" /db_xref="InterPro:IPR011045" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12464" /db_xref="UniProtKB/Swiss-Prot:P71004" /translation="MKKNDLSALQENCFCFCDEEISREAPFQVPIDFPEGFKVDTAEA SAAVTWSTDNLSCISEPCLIQTGPEPEDIGVRYAVRVQGTITLLVSVSPVRNQYGQGD GAVSVIHTEEIDQVVYYAAQSGRCPDFSQITVEDLLIVPPFYGSPLTVAGTLVLPPSP DPQSYVFTANTGDSTVSVIDADLNTVVKTIPFSDVPTNLGVTFDKAFTYVLHGNTNLV SVIDNKTLTIINTITVGGGPRKIEFDPTDEFAYVMAAGSIYVINTASQSVIDVIPIPG ALDFALDPNGQYVYTANGSSWSVDKYDVNTGQLVESIIDTFEFPSLITTPYAGNFAYV LNGELWPKGVTEISLSPLSRGGDFSRLFETLRTIVFSLDSTRAYFLEPYSEPFLINNL YVVNTARQRIIANVSLPGAFDLAVTPDKQYIYAAQPNDNAVTVYRTSDYTAVTVIPVG AGPSAIAM*" /label="ywhL CDS" gene complement(3350843..3352219) /gene="ywhL" /locus_tag="BSU_37440" /old_locus_tag="BSU37440" /label="ywhL gene" CDS complement(3352258..3353613) /gene="ywhK" /locus_tag="BSU_37450" /old_locus_tag="BSU37450" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12073041" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12073041; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor interacting with DNA helicase PcrA" /protein_id="NP_391625.1" /db_xref="EnsemblGenomes-Gn:BSU37450" /db_xref="EnsemblGenomes-Tr:CAB15772" /db_xref="InterPro:IPR011045" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12463" /db_xref="UniProtKB/Swiss-Prot:P71003" /translation="MRKNKLSFKEKAGAEQEECLCFCEGEASREAMFQAPIELPEGFV VDPAEAVANVTWNADSLSCVSDRCLIQTGPEPDEVGVQFAVRLQGTVTLLVSVSPVRN QYGQGDGAVSVIHNAEIDQVVYYSDESDDCPDISDITIENLVVVPPFYGSPLSVTGTI VLVPEPEPVYAFTANPNDQSVSVIDTNTDTVVTTIALPYNPAGIEITPDKSAVFVLHP NNNVISVIDYDTLTVTATILLDQPPRLIRFIPNHEFAYVFTGTAVYVIGIDTLTVDRS IPVEGYDVAIDPNGLFAYVLNFGIVQKVDLTTGEVTGTIERELIVSTIETNWPERYAY VLEQEFFFNYLTVIDLNTFTISSTQELEYEGEYRMFTSGAEVYLYDGFTGNLYSVSPN GAGVIGNVPQSATDYAFTPNGDFLYATRFIEQSIIVYNTDDYSEETVISLGVSPGAIT I*" /label="ywhK CDS" gene complement(3352258..3353613) /gene="ywhK" /locus_tag="BSU_37450" /old_locus_tag="BSU37450" /label="ywhK gene" promotor_-10 complement(3353649..3353668) /Source="Nicolas_upshift_promotors" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3353667) /Source="Nicolas_upshifts" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3353681..3353690) /Source="Nicolas_upshift_promotors" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3353793..3353812 /Source="Nicolas_upshift_promotors" /id="U2946" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.899100899100899" /psig="0.921078921078921" /xcortree=683 /SigmaFactorBS="aacatgcggtgtaacgaaagaaaaaattgcggtttttttgcg cttctcacaagaatgttGATGATAAAATATGACATATatagaattatgaagggaggga t" /listShort="rapF, phrF, S1451, ywhH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3353794 /Source="Nicolas_upshifts" /id="U2946" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.899100899100899" /psig="0.921078921078921" /xcortree=683 /SigmaFactorBS="aacatgcggtgtaacgaaagaaaaaattgcggtttttttgcg cttctcacaagaatgttGATGATAAAATATGACATATatagaattatgaagggaggga t" /listShort="rapF, phrF, S1451, ywhH" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(3353839) /Source="Nicolas_upshifts" /id="D1937" /incds=0 /nref=7 /ntot=59 /MaxReadThrough="2.35357" /MaxDrop="4.85842" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=1867 /isTUend="FALSE" /label="downshifts" CDS 3353843..3354988 /gene="rapF" /locus_tag="BSU_37460" /old_locus_tag="BSU37460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15968044, 16816200, 23526880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15968044, 16816200, 23526880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase anti-activator of ComA" /protein_id="NP_391626.1" /db_xref="EnsemblGenomes-Gn:BSU37460" /db_xref="EnsemblGenomes-Tr:CAB15773" /db_xref="GOA:P71002" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:3ULQ" /db_xref="PDB:4I9C" /db_xref="PDB:4I9E" /db_xref="SubtiList:BG11968" /db_xref="UniProtKB/Swiss-Prot:P71002" /translation="MTGVISSSSIGEKINEWYMYIRRFSIPDAEYLRREIKQELDQME EDQDLHLYYSLMEFRHNLMLEYLEPLEKMRIEEQPRLSDLLLEIDKKQARLTGLLEYY FNFFRGMYELDQREYLSAIKFFKKAESKLIFVKDRIEKAEFFFKMSESYYYMKQTYFS MDYARQAYEIYKEHEAYNIRLLQCHSLFATNFLDLKQYEDAISHFQKAYSMAEAEKQP QLMGRTLYNIGLCKNSQSQYEDAIPYFKRAIAVFEESNILPSLPQAYFLITQIHYKLG KIDKAHEYHSKGMAYSQKAGDVIYLSEFEFLKSLYLSGPDEEAIQGFFDFLESKMLYA DLEDFAIDVAKYYHERKNFQKASAYFLKVEQVRQLIQGGVSLYEIEV*" /label="rapF CDS" gene 3353843..3354988 /gene="rapF" /locus_tag="BSU_37460" /old_locus_tag="BSU37460" /label="rapF gene" promotor_-35 3354847..3354851 /Source="Nicolas_upshift_promotors" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3354868..3354887 /Source="Nicolas_upshift_promotors" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3354875 /Source="Nicolas_upshifts" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(3354958) /Source="Nicolas_upshifts" /id="D1938" /incds=0 /nref=1 /ntot=59 /MaxReadThrough="1.70728" /MaxDrop="2.74755" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=748 /isTUend="FALSE" /label="downshifts" CDS 3354972..3355091 /gene="phrF" /locus_tag="BSU_37470" /old_locus_tag="BSU37470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15968044, 16816200, 23526880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15968044, 16816200, 23526880; Product type f: factor" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapF" /protein_id="NP_391627.1" /db_xref="EnsemblGenomes-Gn:BSU37470" /db_xref="EnsemblGenomes-Tr:CAB15774" /db_xref="GOA:P71001" /db_xref="InterPro:IPR025899" /db_xref="SubtiList:BG11960" /db_xref="UniProtKB/Swiss-Prot:P71001" /translation="MKLKSKLLLSCLALSTVFVATTIANAPTHQIEVAQRGMI*" /label="phrF CDS" gene 3354972..3355091 /gene="phrF" /locus_tag="BSU_37470" /old_locus_tag="BSU37470" /label="phrF gene" downshifts 3355076 /Source="Nicolas_upshifts" /id="D1939" /incds=0 /nref=240 /ntot=268 /MaxReadThrough="5.48985" /MaxDrop="6.14096" /score="19.6493244" /energy="-9.9" /TU="U2946" /idTUdmin="U2947" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" S_feature 3355121..3355189 /Source="Nicolas_S_feature" /locus_tag="new_3847279_3847347" /HighExp="S2, S3, S4, S5, S6, S1, BT, S7, S8, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.921" /TUlongSig="NA" /TUlongPSig="NA" /label="S1451" CDS 3355190..3355663 /gene="ywhH" /locus_tag="BSU_37480" /old_locus_tag="BSU37480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA editing enzyme" /protein_id="NP_391628.1" /db_xref="EnsemblGenomes-Gn:BSU37480" /db_xref="EnsemblGenomes-Tr:CAB15775" /db_xref="GOA:P71000" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG12462" /db_xref="UniProtKB/Swiss-Prot:P71000" /translation="MSLKSVRTHFTQWNRENDVTEFETSSATVEQAAETIGVSLSRIA KSLSFRGEGDQVILIVAAGDAKIDNKKSRQTFGFKARMLSPNEVLEQTGHEIGGVCPF GLAHDPEVYLDVSLKRFQTVFPACGSRNSAIELTPKELSEFSFSKVWIDVCKDWE*" /label="ywhH CDS" gene 3355190..3355663 /gene="ywhH" /locus_tag="BSU_37480" /old_locus_tag="BSU37480" /label="ywhH gene" downshifts 3355652 /Source="Nicolas_upshifts" /id="D1940" /incds=0 /nref=30 /ntot=156 /MaxReadThrough="2.85314" /MaxDrop="4.40065" /score="-6.80415499" /energy="-11.3" /TU="NA" /idTUdmin="U2946" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3355695..3356567) /gene="speB" /locus_tag="BSU_37490" /old_locus_tag="BSU37490" /EC_number="3.5.3.11" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9723923, 10931887, 24678831, 28807600, 28291380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 10931887, 24678831, 28807600, 28291380; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="agmatinase" /protein_id="NP_391629.1" /db_xref="EnsemblGenomes-Gn:BSU37490" /db_xref="EnsemblGenomes-Tr:CAB15776" /db_xref="GOA:P70999" /db_xref="InterPro:IPR005925" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="SubtiList:BG12461" /db_xref="UniProtKB/Swiss-Prot:P70999" /translation="MRFDEAYSGKVFIASRPEWEEADAILYGMPMDWTVSYRPGSRFG PSRIREVSIGLEEYSPYLDRDLADLNFFDAGDIPLPFGNPQRSLDMIEEYVDSILEKG KFPMGMGGEHLVSWPVIKAMYKKYPDLAIIHFDAHTDLRVDYEGEPLSHSTPIRKAAE LIGPHNVYSFGIRSGMKEEFEWAKENGMHISKFEVLEPLKEVLPKLAGRPVYVTIDID VLDPAHAPGTGTVDAGGITSKELLASVHEIARSEVNVKGADLVEVAPVYDHSEQTANT ASKIIREMLLGFVK*" /label="speB CDS" gene complement(3355695..3356567) /gene="speB" /locus_tag="BSU_37490" /old_locus_tag="BSU37490" /label="speB gene" downshifts complement(3355706) /Source="Nicolas_upshifts" /id="D1941" /incds=0 /nref=49 /ntot=171 /MaxReadThrough="2.5482" /MaxDrop="5.46925" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3355772) /Source="Nicolas_upshifts" /id="D1942" /incds=1 /nref=8 /ntot=50 /MaxReadThrough="5.83631" /MaxDrop="3.87062" /score="29.5788849" /energy="-11.3" /TU="U2948" /idTUdmin="U2948" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(3356628..3357458) /gene="speE" /locus_tag="BSU_37500" /old_locus_tag="BSU37500" /EC_number="2.5.1.16" /function="16.3: Control" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9723923, 26735940, 28546427, 28807600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 26735940, 28546427, 28807600; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spermidine synthase; polyamine metabolism" /protein_id="NP_391630.1" /db_xref="EnsemblGenomes-Gn:BSU37500" /db_xref="EnsemblGenomes-Tr:CAB15777" /db_xref="GOA:P70998" /db_xref="InterPro:IPR001045" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030373" /db_xref="InterPro:IPR030374" /db_xref="InterPro:IPR035246" /db_xref="InterPro:IPR037163" /db_xref="PDB:1IY9" /db_xref="SubtiList:BG12460" /db_xref="UniProtKB/Swiss-Prot:P70998" /translation="MSELWYTEKQTKNFGITMKVNKTLHTEQTEFQHLEMVETEEFGN MLFLDGMVMTSEKDEFVYHEMVAHVPLFTHPNPEHVLVVGGGDGGVIREILKHPSVKK ATLVDIDGKVIEYSKKFLPSIAGKLDDPRVDVQVDDGFMHIAKSENQYDVIMVDSTEP VGPAVNLFTKGFYAGIAKALKEDGIFVAQTDNPWFTPELITNVQRDVKEIFPITKLYT ANIPTYPSGLWTFTIGSKKYDPLAVEDSRFFDIETKYYTKDIHKAAFVLPKFVSDLIK *" /label="speE CDS" gene complement(3356628..3357458) /gene="speE" /locus_tag="BSU_37500" /old_locus_tag="BSU37500" /label="speE gene" S_feature complement(3357459..3357554) /Source="Nicolas_S_feature" /locus_tag="new_3849617_3849712_c" /HighExp="Paraq, G180, Oxctl, H2O2, LBGexp, G150, G135, C30, dia15, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1452" promotor_-10 complement(3357542..3357561) /Source="Nicolas_upshift_promotors" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3357553) /Source="Nicolas_upshifts" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3357574..3357581) /Source="Nicolas_upshift_promotors" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3357599..3357604 /Source="Nicolas_upshift_promotors" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3357620..3357638 /Source="Nicolas_upshift_promotors" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3357622 /Source="Nicolas_upshifts" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="upshifts" CDS 3357660..3359735 /gene="pbpG" /locus_tag="BSU_37510" /old_locus_tag="BSU37510" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10767540, 11567005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10767540, 11567005; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation specific penicillin-binding protein 2D" /protein_id="NP_391631.2" /db_xref="EnsemblGenomes-Gn:BSU37510" /db_xref="EnsemblGenomes-Tr:CAB15778" /db_xref="GOA:P70997" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG12459" /db_xref="UniProtKB/Swiss-Prot:P70997" /translation="MDAMTNKRLRLTLKTVRAFIFLGAFAALAAAAVFMTVILIAKYQ GAPSVQVPQSTILYASDGSKLGETNYGEKRYWVPLKDMNPTIVKATVAIEDQNFYDHH GFDYKRMAGAALADLKAFAKVQGASTITQQYARNLYLEHDKTWKRKWNEAFYTIRLEQ NYSKDEILEGYLNTIYYGHGAYGIEAASRLYFGKHAKNLTDAEAALLAGIPKGPSGYS PYVNETKAKERQKTIVRMMEKQQMISQKKADELIKEPLSYQPLNKQVSKRKAPYFYDN AMRELEKKLGMTREQIETSGLNVYTTVDKRMQRIAEETITETVNAGSDIQVGFSAIDP RTGNVLALVGGRDYQKSPFDRTTQAKRQPASTIKPLLYYKAIQSGFTPVTLMKSEETE FQIDAKGETYSPSNYNGYYANKPITLLQALALSDNIYAVKTHLFLGTNKLVKTAKEFG ITAHLQALPSLALGTEPVRPIEMVNAYAMLANGGKKIEPTFISRVTDAAGHVLYENPN QHKQVLDEKAAFVTASMMTGMFDIDLNGYTSVTGRTIANRLTRTYAGKSGTTSADSWM IGFNPKLAAGVWTGYDKNSTIDSVEEKSYAKTIWADFMEDALKGEPETAFKPPKGVTG VYIDPETGYSSGPGCAAKHYTYFVKGTEPANVCYGAEPAKQTKDRLPSKEKPASEKKW WDKWLGRHH*" /label="pbpG CDS" gene 3357660..3359735 /gene="pbpG" /locus_tag="BSU_37510" /old_locus_tag="BSU37510" /label="pbpG gene" downshifts complement(3359788) /Source="Nicolas_upshifts" /id="D1943" /incds=0 /nref=2 /ntot=122 /MaxReadThrough="1.43573" /MaxDrop="3.61075" /score="-7.59753556" /energy="-10.7" /TU="NA" /idTUdmin="U2951" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" S_feature complement(3359912..3360027) /Source="Nicolas_S_feature" /locus_tag="new_3852070_3852185_c" /HighExp="Sw, C90, BI, dia5, dia15, Diami, LBGexp, M0t45, Lbexp, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1453" downshifts complement(3359955) /Source="Nicolas_upshifts" /id="D1944" /incds=0 /nref=198 /ntot=248 /MaxReadThrough="3.25498" /MaxDrop="6.4287" /score="-7.59753556" /energy="-10.7" /TU="U2951,U2952" /idTUdmin="U2952" /TUdmin="-156" /isTUend="FALSE" /label="downshifts" CDS complement(3360028..3360546) /gene="ywhD" /locus_tag="BSU_37520" /old_locus_tag="BSU37520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391632.1" /db_xref="EnsemblGenomes-Gn:BSU37520" /db_xref="EnsemblGenomes-Tr:CAB15779" /db_xref="InterPro:IPR014852" /db_xref="SubtiList:BG12458" /db_xref="UniProtKB/Swiss-Prot:P70996" /translation="MEEKKKKSIGFNIIKSDPTDGHGGFGVGALSLDNISPVFVDVEE KEAFVDIGAMHARSTVEKGIKFLPNKEEVPNGKPYWLVWVTIDRKEEGPYYAGVTACE MTVDRSIRRGYKSLPEHVNLMDKSMKRKIIVDKMDDSSKRVLGEFLKKHDQGLWDRSS DELKTSLLPENN*" /label="ywhD CDS" gene complement(3360028..3360546) /gene="ywhD" /locus_tag="BSU_37520" /old_locus_tag="BSU37520" /label="ywhD gene" CDS complement(3360560..3361219) /gene="ywhC" /locus_tag="BSU_37530" /old_locus_tag="BSU37530" /EC_number="3.4.24.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25649915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase; integral membrane protein" /protein_id="NP_391633.1" /db_xref="EnsemblGenomes-Gn:BSU37530" /db_xref="EnsemblGenomes-Tr:CAB15780" /db_xref="GOA:P70995" /db_xref="InterPro:IPR008915" /db_xref="SubtiList:BG12457" /db_xref="UniProtKB/Swiss-Prot:P70995" /translation="MDRFLYYPLSLMPYLVITLIVSFTMHELAHAYVAYKFGDDTAKK QGRLTLNPIKHLDPFGTILILVAGFGWARPIPVNRRFFKKPRLAGVLVSIAGPVSNLI LAFIGFFLLVLMHAYGMEMLAAFSTGLDQFFSIWIQLNLVLFLFNLLPLPPLDGYRII EDLVPPGVRAKMTQAESYGFIVFLVLFVTPLGSYVLWPMLNAGRDSILKLFSAIFQPL L*" /label="ywhC CDS" gene complement(3360560..3361219) /gene="ywhC" /locus_tag="BSU_37530" /old_locus_tag="BSU37530" /label="ywhC gene" promotor_-35 3361242..3361245 /Source="Nicolas_upshift_promotors" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3361255..3361274) /Source="Nicolas_upshift_promotors" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 3361260..3361279 /Source="Nicolas_upshift_promotors" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3361263 /Source="Nicolas_upshifts" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3361273) /Source="Nicolas_upshifts" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3361275..3361558) /Source="Nicolas_S_feature" /locus_tag="new_3853433_3853716_c" /HighExp="Diami, dia5, dia15, C90, Etha, Sw, H2O2, G135, M40t45, Lbtran" /AntisenseName="ywhB" /AntisenseCor="0.10541372702249199" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1454" promotor_-35 complement(3361289..3361296) /Source="Nicolas_upshift_promotors" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3361328..3361516 /gene="hmtB" /locus_tag="BSU_37540" /old_locus_tag="BSU37540" /EC_number="5.3.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12051677, 14624569, 14730980, 15301547, 17902707" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12051677, 14624569, 14730980, 15301547, 17902707; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-hydroxymuconate tautomerase (promiscuous)" /protein_id="NP_391634.1" /db_xref="EnsemblGenomes-Gn:BSU37540" /db_xref="EnsemblGenomes-Tr:CAB15781" /db_xref="GOA:P70994" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="InterPro:IPR018191" /db_xref="PDB:2OP8" /db_xref="PDB:2OPA" /db_xref="SubtiList:BG12456" /db_xref="UniProtKB/Swiss-Prot:P70994" /translation="MPYVTVKMLEGRTDEQKRNLVEKVTEAVKETTGASEEKIVVFIE EMRKDHYAVAGKRLSDME*" /label="hmtB CDS" gene 3361328..3361516 /gene="hmtB" /locus_tag="BSU_37540" /old_locus_tag="BSU37540" /label="hmtB gene" downshifts 3361505 /Source="Nicolas_upshifts" /id="D1945" /incds=0 /nref=72 /ntot=213 /MaxReadThrough="1.74275" /MaxDrop="4.93207" /score="4.21502693" /energy="-10.5" /TU="NA" /idTUdmin="U2950" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3361559..3361978) /gene="ywhA" /locus_tag="BSU_37550" /old_locus_tag="BSU37550" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391635.1" /db_xref="EnsemblGenomes-Gn:BSU37550" /db_xref="EnsemblGenomes-Tr:CAB15782" /db_xref="GOA:P70993" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12455" /db_xref="UniProtKB/Swiss-Prot:P70993" /translation="MDHDKLEANLLDHALTKYLKSTKQLDEATVPKHVNNVRGFILRI IYRHGSCTIKDILKEVTLSPSATTTALNHLEQEGFIERSRNNNDRRTVWITLSESGRG AAEQMIENRQQLIDGMFERLTAEEKKTFLAIIAKLAQ*" /label="ywhA CDS" gene complement(3361559..3361978) /gene="ywhA" /locus_tag="BSU_37550" /old_locus_tag="BSU37550" /label="ywhA gene" promotor_-10 complement(3362028..3362047) /Source="Nicolas_upshift_promotors" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3362039) /Source="Nicolas_upshifts" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3362062..3362069) /Source="Nicolas_upshift_promotors" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3362098..3364014) /gene="thrZ" /locus_tag="BSU_37560" /old_locus_tag="BSU37560" /EC_number="6.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9353933, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9353933, 15831787; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonyl-tRNA synthetase" /protein_id="NP_391636.2" /db_xref="EnsemblGenomes-Gn:BSU37560" /db_xref="EnsemblGenomes-Tr:CAB15783" /db_xref="GOA:P18256" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002320" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR033728" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG10421" /db_xref="UniProtKB/Swiss-Prot:P18256" /translation="MSKHVHIQLPDGQIQEYPKGITIKEAAGSISSSLQKKAAAGQVN GKLVDLSFKLEEDAELSIVTLDSQEGLQVLRHTTAHVLAQAVKRLYGEVSLGVGPVIL DGFYYDMKLGKSLASGDLEAIEKEMKNIINENLEIKRIEVSYEEAEELFAQKDERLKL EILKDIPRGEDITLYQQGEFVDLCRGPHLPSTGMIKAFKLTRVSGAYWRGDSKNEVLQ RVYGVAFQKKKDLDAHLHMLEEAAKRDHRKLGKQLGLFMFSEEAPGMPFYLPKGQIVR NELERFSRELQTNAGYDEVRTPFMMNQRLWEQSGHWDHYRDNMYFSEVDDTRFAMKPM NCPGHMLIFKNSLYSYRDLPIRMAEFGQVHRHEYSGALNGMLRVRTFCQDDAHIFVRE DQIESEIKEAIRLIDEVYRTFGFEYSVELSTRPEDSLGDDSLWEASERALARVLEELG LSYEINEGDGAFYGPKIDFHIKDALKRSHQCATIQLDFQMPEKFDLTYINELNEKVRP VVIHRAVFGSIDRFFGILIEHYGGAFPVWLAPIQVQIIPVSHVHLDYCRKVQAELKQA GIRAGIDERNEKLGYKIRESQVQKIPYVLVLGDHEEQENAVNVRRFGHQQNEHVPFQT FKDKLVKQVENRGM*" /label="thrZ CDS" gene complement(3362098..3364014) /gene="thrZ" /locus_tag="BSU_37560" /old_locus_tag="BSU37560" /label="thrZ gene" promotor_-10 complement(3363292..3363310) /Source="Nicolas_upshift_promotors" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3363297) /Source="Nicolas_upshifts" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3363327..3363331) /Source="Nicolas_upshift_promotors" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3364045) /Source="Nicolas_upshifts" /id="D1946" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="4.2774" /MaxDrop="3.56231" /score="36.3785359" /energy="-19.5" /TU="U2955" /idTUdmin="U2953" /TUdmin="-968" /isTUend="FALSE" /label="downshifts" misc_RNA complement(3364068..3364289) /gene="tboTB" /locus_tag="BSU_misc_RNA_57" /product="T-box" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787; Product type n: RNA" /function="16.3: Control" /label="tboTB RNA" gene complement(3364068..3364289) /gene="tboTB" /locus_tag="BSU_misc_RNA_57" /label="tboTB gene" misc_RNA complement(3364321..3364542) /gene="tboTA" /locus_tag="BSU_misc_RNA_58" /product="T-box riboswitch specific of threonine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787; Product type n: RNA" /function="16.3: Control" /label="tboTA RNA" gene complement(3364321..3364542) /gene="tboTA" /locus_tag="BSU_misc_RNA_58" /label="tboTA gene" S_feature complement(3364574..3364836) /Source="Nicolas_S_feature" /locus_tag="new_3856732_3856994_c" /HighExp="S8, S7, S6, S5, BT, Sw, B36, B60, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.61719100000000005" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1455" downshifts 3364585 /Source="Nicolas_upshifts" /id="D1947" /incds=0 /nref=1 /ntot=17 /MaxReadThrough="0.92811" /MaxDrop="3.85666" /score="1.17237511" /energy="-8.3" /TU="NA" /idTUdmin="U2950" /TUdmin=3080 /isTUend="FALSE" /label="downshifts" downshifts complement(3364617) /Source="Nicolas_upshifts" /id="D1948" /incds=0 /nref=52 /ntot=200 /MaxReadThrough="6.68945" /MaxDrop="6.6969" /score="36.414771" /energy="-17.3" /TU="U2955" /idTUdmin="U2953" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" CDS complement(3364624..3364779) /locus_tag="BSU_37569" /old_locus_tag="BSU37569" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514011.1" /translation="MLFTVSREGRTAEIFLTQGKQLTAFEPYQGKQVSDTVMLRYSIF KPIIMCN*" /label="hypothetical protein CDS" gene complement(3364624..3364779) /locus_tag="BSU_37569" /old_locus_tag="BSU37569" /label="gene" promotor_-35 3364786..3364789 /Source="Nicolas_upshift_promotors" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3364798..3364811 /Source="Nicolas_upshift_promotors" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3364805 /Source="Nicolas_upshifts" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3364813..3364832) /Source="Nicolas_upshift_promotors" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3364836) /Source="Nicolas_upshifts" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3364846..3364852) /Source="Nicolas_upshift_promotors" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3364859..3366259) /gene="mmr" /locus_tag="BSU_37570" /old_locus_tag="BSU37570" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11104814, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11104814, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="toxic compound efflux transporter (may export homoserine)" /protein_id="NP_391637.1" /db_xref="EnsemblGenomes-Gn:BSU37570" /db_xref="EnsemblGenomes-Tr:CAB15784" /db_xref="GOA:Q00538" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10420" /db_xref="UniProtKB/Swiss-Prot:Q00538" /translation="MKNSGSIQESTSSTGISVLIVLALGFLMATLDVTVVNVAMADMK NTLSMSLSGVTWVVDGYILTFASLLLAGGALADRFGSKTIYILGLAVFVMASCLCAAS INGQMLIAGRLIQGIGAALFMPSSLSLLAASYLDERARARMFGLWAALVSAASALGPF IGGVLVQLAGWQSIFLINVPIGAAALISAYRILSRVPGKSSRVNIIGHLLGMMALGFL SYALIQGPSAGWRSPVILVAFTAAVLAFVLFLLREISAKTPILPASLYKNGRFSAAQF IGFLLNFALFGGMFMLSLFLQEAGGASSFMAGVELLPMMAVFVIGNLLFARLANRFEA GQLMFVSMAVSCIIALLLFVLISPDFPYWQLAVLMSVMNLCTGITVPAMTTVIMQAAG QRHTNIAGAALNANRQIGALVGVAITGVIIHLSATWYAGAGFAFLMMGAAYSLAALLV WLFLAAHNGTAASEKM*" /label="mmr CDS" gene complement(3364859..3366259) /gene="mmr" /locus_tag="BSU_37570" /old_locus_tag="BSU37570" /label="mmr gene" CDS complement(3366259..3366729) /gene="ywgB" /locus_tag="BSU_37580" /old_locus_tag="BSU37580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16885456; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391638.1" /db_xref="EnsemblGenomes-Gn:BSU37580" /db_xref="EnsemblGenomes-Tr:CAB15785" /db_xref="GOA:P71047" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12454" /db_xref="UniProtKB/Swiss-Prot:P71047" /translation="MKMKSGMEQAVSVLLLLSRLPVQASLTSEAISQRLRVSPSYLKK LMRTLVQAGLAESLPGTKGGFTLTKPLADITLYDVYQAVEGRGSMYQGKGLLQSVFEG ESHCVLETVMAEIEDKWSNLMREESLQHVMDRVGELYDLEKIDDWVIKQVKGQL*" /label="ywgB CDS" gene complement(3366259..3366729) /gene="ywgB" /locus_tag="BSU_37580" /old_locus_tag="BSU37580" /label="ywgB gene" downshifts complement(3366685) /Source="Nicolas_upshifts" /id="D1949" /incds=0 /nref=11 /ntot=145 /MaxReadThrough="2.78131" /MaxDrop="4.29115" /score="17.3758052" /energy="-11.2" /TU="NA" /idTUdmin="U2956" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3366841..3367341) /gene="ywgA" /locus_tag="BSU_37590" /old_locus_tag="BSU37590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16855250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391639.1" /db_xref="EnsemblGenomes-Gn:BSU37590" /db_xref="EnsemblGenomes-Tr:CAB15786" /db_xref="SubtiList:BG12453" /db_xref="UniProtKB/Swiss-Prot:P71046" /translation="MLKEHAKLMKVFSDSGEIIGRKKLQKMIYIAKKMQFPFYEKYDF HFYGPYSEELTLQIEELCNLGFLHEVKEKKGGYFQYRYSLTETGSAFLDHADLDMPDM KGYIDSVNSRSSRFLELVSTILYFDGLEDEEKKEKVFTIKSKQKYTNEEYDEALQYIE ELKQIC*" /label="ywgA CDS" gene complement(3366841..3367341) /gene="ywgA" /locus_tag="BSU_37590" /old_locus_tag="BSU37590" /label="ywgA gene" downshifts complement(3366844) /Source="Nicolas_upshifts" /id="D1950" /incds=0 /nref=9 /ntot=105 /MaxReadThrough="4.00805" /MaxDrop="6.12059" /score="17.3758052" /energy="-11.2" /TU="U2956,U2957" /idTUdmin="U2957" /TUdmin="-137" /isTUend="FALSE" /label="downshifts" CDS complement(3367377..3368678) /gene="ywfO" /locus_tag="BSU_37600" /old_locus_tag="BSU37600" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16855250; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent nucleotide (pyro)phosphohydrolase" /protein_id="NP_391640.1" /db_xref="EnsemblGenomes-Gn:BSU37600" /db_xref="EnsemblGenomes-Tr:CAB15787" /db_xref="GOA:P39651" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG10639" /db_xref="UniProtKB/Swiss-Prot:P39651" /translation="MAYPNGKLSEEKVFKDPVHRYVHVRDKLIWDLIGTREFQRLRRI KQLGTTYLTFHGAEHSRFNHSLGVYEIVRRMVDDVFKGRPEWDDSERELCLAAALLHD LGHGPFSHSFEKVFHLDHEDFTRGIILGDTEVNQVLRKVSPGFPQDVAEVIAKTYKNK QVVSLISSQIDADRMDYLQRDAYYTGVSYGHFDMERILRVMRPREDQIVIKESGMHAV EDYIMSRYQMYWQVYFHPVTRSAEVILTKILHRAKQLHDEGYVFTHAPVHFYSIFEGK LTLEDYVKLDESIILYYFQAWEDEEDAILSDLCRRFINRQLFQYVEFNPNEEMSAYFE LTSLFKEAGIDPSYYLVVDSSSDLPYDFYRPGEEEERLPIHLLTQNGQIKELSRQSAI VESISGKRRTDHKLYYPKDLICDGTKHPEAKMKIRQLLGLT*" /label="ywfO CDS" gene complement(3367377..3368678) /gene="ywfO" /locus_tag="BSU_37600" /old_locus_tag="BSU37600" /label="ywfO gene" promotor_-10 complement(3368702..3368721) /Source="Nicolas_upshift_promotors" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3368716) /Source="Nicolas_upshifts" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3368718..3368839) /Source="Nicolas_S_feature" /locus_tag="new_3860876_3860997_c" /HighExp="G180, Paraq, Oxctl, G135, H2O2, G150, C30, LBGstat, LBGexp, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1456" promotor_-35 complement(3368737..3368739) /Source="Nicolas_upshift_promotors" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3368840..3369064) /gene="ywzC" /locus_tag="BSU_37610" /old_locus_tag="BSU37610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16855250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391641.1" /db_xref="EnsemblGenomes-Gn:BSU37610" /db_xref="EnsemblGenomes-Tr:CAB15788" /db_xref="InterPro:IPR009910" /db_xref="InterPro:IPR020880" /db_xref="SubtiList:BG14164" /db_xref="UniProtKB/Swiss-Prot:O32280" /translation="MANEFRVCDDCQATNIKTLLPRLKEVDPDAKVEVGCQSYCGPGR KKSFAFVNNRPLSAPTEDELIDKVKKKIKK*" /label="ywzC CDS" gene complement(3368840..3369064) /gene="ywzC" /locus_tag="BSU_37610" /old_locus_tag="BSU37610" /label="ywzC gene" S_feature complement(3369065..3369149) /Source="Nicolas_S_feature" /locus_tag="new_3861223_3861307_c" /HighExp="G180, Paraq, H2O2, G135, LBGexp, dia15, G150, Lbexp, Heat, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1457" promotor_-10 complement(3369138..3369157) /Source="Nicolas_upshift_promotors" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3369148) /Source="Nicolas_upshifts" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3369172..3369175) /Source="Nicolas_upshift_promotors" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3369215..3369221 /Source="Nicolas_upshift_promotors" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3369236..3369247 /Source="Nicolas_upshift_promotors" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3369237 /Source="Nicolas_upshifts" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="upshifts" CDS 3369279..3370055 /gene="psrF" /locus_tag="BSU_37620" /old_locus_tag="BSU37620" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10629188, 16497325, 22829778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629188, 16497325, 22829778; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="prespore-specific transcription regulatory gene" /protein_id="NP_391642.1" /db_xref="EnsemblGenomes-Gn:BSU37620" /db_xref="EnsemblGenomes-Tr:CAB15789" /db_xref="GOA:P39650" /db_xref="InterPro:IPR014243" /db_xref="InterPro:IPR017877" /db_xref="SubtiList:BG10638" /db_xref="UniProtKB/Swiss-Prot:P39650" /translation="MTKQRQDAWSEENDLLLAETVLRHVREGSTQLNAFEEVGDKLNR TSAACGFRWNAVVRHQYEKALQLAKKQRKQRMRALGNGQPAKKRLLYQPPAVDPEIIQ ETAAEEPVKTETPSVENEQPLMSGEHMPFVDESFKEELASLSHLLSPQTPAAAPEMTM NDVIRFLQNYEGNHEQSSALKMENERLKKENQELQNKTEQLEAEVQKLEKDQKTIQED YETLVKIMNRARKLVLFEEDEHASPSFKMDRNGNLEKLAE*" /label="psrF CDS" gene 3369279..3370055 /gene="psrF" /locus_tag="BSU_37620" /old_locus_tag="BSU37620" /label="psrF gene" downshifts 3370041 /Source="Nicolas_upshifts" /id="D1951" /incds=0 /nref=14 /ntot=78 /MaxReadThrough="4.08166" /MaxDrop="4.36214" /score="-5.88286948" /energy="-14.4" /TU="U2958" /idTUdmin="U2958" /TUdmin="-3036" /isTUend="FALSE" /label="downshifts" promotor_-35 3370143..3370150 /Source="Nicolas_upshift_promotors" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3370165..3370184 /Source="Nicolas_upshift_promotors" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3370169..3374395 /Source="Nicolas_S_feature" /locus_tag="new_3862327_3866553" /HighExp="T1.30H, T2.0H, T1.0H, T2.30H, T0.30H, T3.0H, T3.30H, T4.0H, T5.0H, T0.0H" /AntisenseName="pta" /AntisenseCor="-0.61235087907102503" /AntisenseRegPval="-28.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.836" /TUlongSig="NA" /TUlongPSig="NA" /label="S1458" upshifts 3370169 /Source="Nicolas_upshifts" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3370199..3371089) /gene="ywfM" /locus_tag="BSU_37630" /old_locus_tag="BSU37630" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative toxic excess metabolite exporter" /protein_id="NP_391643.1" /db_xref="EnsemblGenomes-Gn:BSU37630" /db_xref="EnsemblGenomes-Tr:CAB15790" /db_xref="GOA:P39649" /db_xref="InterPro:IPR000620" /db_xref="InterPro:IPR004779" /db_xref="SubtiList:BG10637" /db_xref="UniProtKB/Swiss-Prot:P39649" /translation="MKGNIYSLFVLIAAFFWGTTGTVQALAPESATPLAFGAFRLLIG GSAMLLAVWISRELHVKNWAWPLVFLAAVCMACYQPLFFTAVKETGIAVGTVIAIGSA PIIAGTLEWAVLKKRPRNSWWIATVLALAGCWLLFSDSSNVRIDVAGVLMALGAGASF AGYTLISKAMMKTQPPRATSAVVFMISAILLTPLLWQLDISWILTPRGLGTSLYIGLI ATCAAYFLFAKGLTGVPASAAVTLSLAEPLTASLLGVFFIGEMLSPSSWLGIALMMLG LLVISAAPRKQKTAEAAHMS*" /label="ywfM CDS" gene complement(3370199..3371089) /gene="ywfM" /locus_tag="BSU_37630" /old_locus_tag="BSU37630" /label="ywfM gene" promotor_no_box complement(3371089..3371189) /Source="Nicolas_upshift_promotors" /id="U2960" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.568431568431568" /psig="0.136863136863137" /xcortree=1729 /SigmaFactorBS="taatcttattttcagataagtccttcttacatacagataacc acgacaaaaagaaaaacgataaaatgacatcagcatccatattaaaggggagaggcag a" /listShort="ywfM" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3371129) /Source="Nicolas_upshifts" /id="U2960" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.568431568431568" /psig="0.136863136863137" /xcortree=1729 /SigmaFactorBS="taatcttattttcagataagtccttcttacatacagataacc acgacaaaaagaaaaacgataaaatgacatcagcatccatattaaaggggagaggcag a" /listShort="ywfM" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3371257..3372102) /gene="lipL" /locus_tag="BSU_37640" /old_locus_tag="BSU37640" /function="4: Biosynthesis of cofactors, prosthetic groups, and carriers" /experiment="publication(s) with functional evidences, PMID:21338420, 21338421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21338420, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="amidotransferase of the octanoyl moiety from octanoyl-GcvH to the E2 subunit of pyruvate dehydrogenase" /protein_id="NP_391644.1" /db_xref="EnsemblGenomes-Gn:BSU37640" /db_xref="EnsemblGenomes-Tr:CAB15791" /db_xref="GOA:P39648" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR024897" /db_xref="SubtiList:BG10636" /db_xref="UniProtKB/Swiss-Prot:P39648" /translation="MANQPIDLLMQPKWRVIDQSSLGPLFDAKQSFAMDDTLCMSVGK GVSPATARSWVHHDTIVLGIQDTRLPFLQDGISLLESEGYRVIVRNSGGLAVVLDDGV LNISLIFEDEKKGIDIDKGYEAMVELMRRMLRPYNAKIEAYEIEGSYCPGSYDLSING KKFAGISQRRVRGGVAVQIYLCADKSGSERADLIRRFYQAALKDKQNDKKGVYPEIRP ETMASLSELLQKDISVQDLMFALLTELKALSTHLYSAGLSIDEEMEFEKNLVRMAERN AKVFG*" /label="lipL CDS" gene complement(3371257..3372102) /gene="lipL" /locus_tag="BSU_37640" /old_locus_tag="BSU37640" /label="lipL gene" downshifts complement(3371420) /Source="Nicolas_upshifts" /id="D1952" /incds=1 /nref=4 /ntot=180 /MaxReadThrough="3.21908" /MaxDrop="3.30122" /score="31.9003746" /energy="-18.6" /TU="U2961" /idTUdmin="U2961" /TUdmin="-27" /isTUend="FALSE" /label="downshifts" CDS complement(3372151..3373050) /gene="cysL" /locus_tag="BSU_37650" /old_locus_tag="BSU37650" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169591" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169591; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of sulfur assimilation CysL, activatescysJI expression" /protein_id="NP_391645.1" /db_xref="EnsemblGenomes-Gn:BSU37650" /db_xref="EnsemblGenomes-Tr:CAB15792" /db_xref="GOA:P39647" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10635" /db_xref="UniProtKB/Swiss-Prot:P39647" /translation="MYYDVLKTFIAVVEEKNFTKAAEKLMISQPSVSLHIKNLEKEFQ TALLNRSPKHFTTTPTGDILYQRAKQMVFLYEQAKAEIYAHHHYVKGELKIAASFTIG EYILPPLLAQLQKLYPELNLDVMIGNTEEVSERVRMLQADIGLIEGHTNENELEIEPF MEDEMCIAAPNQHPLAGRKEISISDLQNEAWVTREKGSGTREYLDHVLSSNGLRPKSM FTISSNQGVKEAVINGMGLSVLSRSVLRKDLIHREISILHINNFSLKRKLSYIHSPLM ENTKNKEIFITMLKSNYQSQLLK*" /label="cysL CDS" gene complement(3372151..3373050) /gene="cysL" /locus_tag="BSU_37650" /old_locus_tag="BSU37650" /label="cysL gene" promotor_-10 complement(3373093..3373112) /Source="Nicolas_upshift_promotors" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3373096) /Source="Nicolas_upshifts" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3373126..3373133) /Source="Nicolas_upshift_promotors" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3373197) /Source="Nicolas_upshifts" /id="D1953" /incds=0 /nref=222 /ntot=251 /MaxReadThrough="1.96406" /MaxDrop="7.24606" /score="32.3178773" /energy="-17.3" /TU="NA" /idTUdmin="U2962" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3373197..3374168) /gene="pta" /locus_tag="BSU_37660" /old_locus_tag="BSU37660" /EC_number="2.3.1.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4201530, 10559153, 10809684, 16283428, 17183215, 17233734, 21453533, 23468065, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4201530, 10559153, 10809684, 16283428, 17183215, 17233734, 21453533, 23468065, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphotransacetylase" /protein_id="NP_391646.1" /db_xref="EnsemblGenomes-Gn:BSU37660" /db_xref="EnsemblGenomes-Tr:CAB15793" /db_xref="GOA:P39646" /db_xref="InterPro:IPR002505" /db_xref="InterPro:IPR004614" /db_xref="InterPro:IPR012147" /db_xref="PDB:1TD9" /db_xref="PDB:1XCO" /db_xref="SubtiList:BG10634" /db_xref="UniProtKB/Swiss-Prot:P39646" /translation="MADLFSTVQEKVAGKDVKIVFPEGLDERILEAVSKLAGNKVLNP IVIGNENEIQAKAKELNLTLGGVKIYDPHTYEGMEDLVQAFVERRKGKATEEQARKAL LDENYFGTMLVYKGLADGLVSGAAHSTADTVRPALQIIKTKEGVKKTSGVFIMARGEE QYVFADCAINIAPDSQDLAEIAIESANTAKMFDIEPRVAMLSFSTKGSAKSDETEKVA DAVKIAKEKAPELTLDGEFQFDAAFVPSVAEKKAPDSEIKGDANVFVFPSLEAGNIGY KIAQRLGNFEAVGPILQGLNMPVNDLSRGCNAEDVYNLALITAAQAL*" /label="pta CDS" gene complement(3373197..3374168) /gene="pta" /locus_tag="BSU_37660" /old_locus_tag="BSU37660" /label="pta gene" promotor_-10 complement(3374203..3374222) /Source="Nicolas_upshift_promotors" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3374228) /Source="Nicolas_upshifts" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3374238..3374242) /Source="Nicolas_upshift_promotors" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3374316..3374327) /Source="Nicolas_upshift_promotors" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3374319) /Source="Nicolas_upshifts" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3374341..3374347) /Source="Nicolas_upshift_promotors" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3374390..3374409 /Source="Nicolas_upshift_promotors" /id="U2964" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=1605 /SigmaFactorBS="ggagttatacggaagggatgttcaaggtttctccacagtaga atcggataaacTATGGTATAGTGAAGGCAATcatgaaaagataatgggagtgaagata a" /listShort="ywfI, ywfH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3374397 /Source="Nicolas_upshifts" /id="U2964" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=1605 /SigmaFactorBS="ggagttatacggaagggatgttcaaggtttctccacagtaga atcggataaacTATGGTATAGTGAAGGCAATcatgaaaagataatgggagtgaagata a" /listShort="ywfI, ywfH" /GFF_Attribute="listLong" /label="upshifts" CDS 3374438..3375202 /gene="hemQ" /locus_tag="BSU_37670" /old_locus_tag="BSU37670" /EC_number="4.1.-.-" /function="4.3: Heme, porphyrin, and cobalamin" /experiment="publication(s) with functional evidences, PMID:15317589, 16403788, 20543190, 25711532, 26083961, 27599156, 27758026, 27597779, 27936663, 27982566" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317589, 16403788, 20543190, 25711532, 26083961, 27599156, 27758026, 27597779, 27936663, 27982566; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-coproporphyrin (coproheme) decarboxylase" /protein_id="NP_391647.3" /db_xref="EnsemblGenomes-Gn:BSU37670" /db_xref="EnsemblGenomes-Tr:CAB15794" /db_xref="GOA:P39645" /db_xref="InterPro:IPR010644" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR031332" /db_xref="SubtiList:BG10633" /db_xref="UniProtKB/Swiss-Prot:P39645" /translation="MSEQQMTNEAAKTLDGWYALHDFRTMDWASWKLLSSDERQSIIH EFTGLLEKWGVAQKEGKGSQTLYSIVGQKADFMLMILRPTMEELNQIELEFNKSRLAE FTIPAYSYVSVVELSNYLASGDGDPYENPHVRARLYPELPESKYVCFYPMDKRRSGND NWYMLSMEERRNLMRSHGLIGRSYAGKVKQIITGSVGFDDYEWGVTLFSDDVLQFKKL VYEMRFDEVSARYGEFGSFFVGNHLSLDTLPQFLYV*" /label="hemQ CDS" gene 3374438..3375202 /gene="hemQ" /locus_tag="BSU_37670" /old_locus_tag="BSU37670" /label="hemQ gene" downshifts 3375189 /Source="Nicolas_upshifts" /id="D1954" /incds=0 /nref=155 /ntot=246 /MaxReadThrough="5.49286" /MaxDrop="6.26609" /score="19.319449" /energy="-14.5" /TU="U2964" /idTUdmin="U2959" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR join(3375209,3375216) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs11" N_region 3375210..3375215 /note="SacI site (GAGCTC)" /created_by="User" /label="IIG_Bs11" S_feature <3375216..3375268 /Source="Nicolas_S_feature" /locus_tag="new_3873771_3874382" /HighExp="Etha, Salt, Gly, Heat, C30, LPhT, HiTm, C90, S8, M/G" /AntisenseName="bacA" /AntisenseCor="9.8443047207874598E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1459" CDS complement(3375218..3376456) /gene="ywfA" /locus_tag="BSU_37750" /old_locus_tag="BSU37750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15609023, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391655.1" /db_xref="EnsemblGenomes-Gn:BSU37750" /db_xref="EnsemblGenomes-Tr:CAB15802" /db_xref="GOA:P39637" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10625" /db_xref="UniProtKB/Swiss-Prot:P39637" /translation="MNSNQNNDIKTKHHFPLLLALALTMGVFAAGSEELVISPLLPDL AKAFSSDVSVLALSISIYGVMIFIGAPLLVPLGDKYSRELSLLAGLMIFIIGTVICAL AQNIFFFFLGRALSGLAAGAFVPTAYAVVGDRVPYTYRGKVMGLIVSSWSLALIFGVP LGSFIGGVLHWRWTFWIFALMGVLVVLLILLEMRRHAQHKNSGKEEIEEPAGTFRDAL KVPRVPVYITITFCNMIGFYGMYSFLGTYLQDVFTGGNTAAGLFIMIYGIGFSMSVIT GKIADRIGKMRSLLIALGVISVLLACLPYAPASMFLLIASLFIWGLMQSLTVTLLSTI LSDCSERHRGKVMVFYSLASNLAVTLGSALMGPVYVAYGYAAVGLICAAITVLGFVLS VFAYKKYGKLEQKADQSLSQ*" /label="ywfA CDS" gene complement(3375218..3376456) /gene="ywfA" /locus_tag="BSU_37750" /old_locus_tag="BSU37750" /label="ywfA gene" promotor_-10 complement(3376498..3376517) /Source="Nicolas_upshift_promotors" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3376510) /Source="Nicolas_upshifts" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3376529..3376536) /Source="Nicolas_upshift_promotors" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3376666..3378078) /gene="rocC" /locus_tag="BSU_37760" /old_locus_tag="BSU37760" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7540694, 8113162, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="basic aminoacid permease" /protein_id="NP_391656.1" /db_xref="EnsemblGenomes-Gn:BSU37760" /db_xref="EnsemblGenomes-Tr:CAB15803" /db_xref="GOA:P39636" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG10624" /db_xref="UniProtKB/Swiss-Prot:P39636" /translation="MQNHKNELQRSMKSRHLFMIALGGVIGTGLFLGSGFTISQAGPL GAIAAYIIGGFLMYLVMLCLGELAVAMPVAGSFQAYATKFLGQSTGFMIGWLYWFSWA NTVGLELTSAGILMQRWLPSVPIWIWCLVFGIVIFLINALSVRSFAEMEFWFSSIKVA AIILFIVIGGAAVFGLIDFKGGQETPFLSNFMTDRGLFPNGVLAVMFTLVMVNFSFQG TELVGIAAGESESPEKTLPKSIRNVIWRTLFFFVLAMFVLVAILPYKTAGVIESPFVA VLDQIGIPFSADIMNFVILTAILSVANSGLYAASRMMWSLSSNQMGPSFLTRLTKKGV PMNALLITLGISGCSLLTSVMAAETVYLWCISISGMVTVVAWMSICASQFFFRRRFLA EGGNVNDLEFRTPLYPLVPILGFCLYGCVLISLIFIPDQRIGLYCGVPIIIFCYAYYH LSIKKRINHETIEKKQTEAQ*" /label="rocC CDS" gene complement(3376666..3378078) /gene="rocC" /locus_tag="BSU_37760" /old_locus_tag="BSU37760" /label="rocC gene" downshifts complement(3376673) /Source="Nicolas_upshifts" /id="D1957" /incds=0 /nref=16 /ntot=112 /MaxReadThrough="1.06691" /MaxDrop="5.69562" /score="41.626335" /energy="-15.9" /TU="NA" /idTUdmin="U2971" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(3378078..3379778) /gene="rocB" /locus_tag="BSU_37770" /old_locus_tag="BSU37770" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8113162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-deacylase involved in arginine and ornithine utilization" /protein_id="NP_391657.1" /db_xref="EnsemblGenomes-Gn:BSU37770" /db_xref="EnsemblGenomes-Tr:CAB15804" /db_xref="GOA:P39635" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR012166" /db_xref="SubtiList:BG10623" /db_xref="UniProtKB/Swiss-Prot:P39635" /translation="MQYTKISHMNPAERVEALTASLVSLSSVNGTVGEGTKADFIKEV ITSYPYFQENPSHVWEQAIPNDPYKRKNIFAFIKGHGESRNTVIYHAHLDTVGIEDFG PLKDIAFDCEKLAEYFSRYEFDQDVQRDAKSGEWMFGRGSVDMQSGIAVHLANLLHFS ENLETLPGNVLFMANPDEESQHSGILASISELNRLKKEKQLHYLAAINTDFITPLYDG DQTRYIYTGAAGKLLPCFYIYGREVHVGDTLAGIDPNFISSEITSRLHNNIHLAEKVE GELVLPPSCLYQRDNKESYNVQTAVSTSLYFNCFIYERTAKEMMDLLIEVTEEACRET EQKLSDYYEEYVKRANLPKKHLSWGIQVYSLEQYLEKLRNRGIDPEQCIEQTFKANEH LELRMRCFQAIEELQKLDPDQGAKVILFYAPPYLPHNYLKEDSARDQLLQHVIKEAAD KTAESTGETFVFKKFFPYLADGSFLSLHETDGEIDSFIRNFPGWNMIGTIPFKDIRKL NIPSINMGVYGKDGHKWTERVYKPYTFHVLPLLIQQTTVHLLQSYRMTITAKEPKGEG *" /label="rocB CDS" gene complement(3378078..3379778) /gene="rocB" /locus_tag="BSU_37770" /old_locus_tag="BSU37770" /label="rocB gene" misc_feature complement(3378747..3378763) /Source="Nicolas_upshift_promotors" /id="U2970" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.238761238761239" /psig="0.613386613386613" /xcortree=2859 /SigmaFactorBS="ggatttgcttattgaagtcactgaggaagcatgccgggagac agaacaaaaattatCAGATTATTACGAAGAAtatgtaaaaagagccaacctgccaaag a" /listShort="rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3378759) /Source="Nicolas_upshifts" /id="U2970" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.238761238761239" /psig="0.613386613386613" /xcortree=2859 /SigmaFactorBS="ggatttgcttattgaagtcactgaggaagcatgccgggagac agaacaaaaattatCAGATTATTACGAAGAAtatgtaaaaagagccaacctgccaaag a" /listShort="rocC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3379852..3381399) /gene="rocA" /locus_tag="BSU_37780" /old_locus_tag="BSU37780" /EC_number="1.2.1.88" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11418582, 12634342, 8113162, 9383188, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="delta-1-pyrroline-5 carboxylate dehydrogenase" /protein_id="NP_391658.1" /db_xref="EnsemblGenomes-Gn:BSU37780" /db_xref="EnsemblGenomes-Tr:CAB15805" /db_xref="GOA:P39634" /db_xref="InterPro:IPR005932" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG10622" /db_xref="UniProtKB/Swiss-Prot:P39634" /translation="MTVTYAHEPFTDFTEAKNKTAFGESLAFVNTQLGKHYPLVINGE KIETDRKIISINPANKEEIIGYASTADQELAEKAMQAALQAFDSWKKQRPEHRANILF KAAAILRRRKHEFSSYLVKEAGKPWKEADADTAEAIDFLEFYARQMLKLKEGAPVKSR AGEVNQYHYEALGVGIVISPFNFPLAIMAGTAVAAIVTGNTILLKPADAAPVVAAKFV EVMEEAGLPNGVLNYIPGDGAEIGDFLVEHPKTRFVSFTGSRAVGCRIYERAAKVQPG QKWLKRVIAEMGGKDTVLVDKDADLDLAASSIVYSAFGYSGQKCSAGSRAVIHQDVYD EVVEKAVALTKTLTVGNPEDPDTYMGPVIHEASYNKVMKYIEIGKSEGKLLAGGEGDD SKGYFIQPTIFADVDENARLMQEEIFGPVVAICKARDFDHMLEIANNTEYGLTGALLT KNRAHIERAREDFHVGNLYFNRGCTGAIVGYQPFGGFNMSGTDSKAGGPDYLILHMQA KTTSEAF*" /label="rocA CDS" gene complement(3379852..3381399) /gene="rocA" /locus_tag="BSU_37780" /old_locus_tag="BSU37780" /label="rocA gene" downshifts complement(3379859) /Source="Nicolas_upshifts" /id="D1958" /incds=0 /nref=4 /ntot=50 /MaxReadThrough="5.60027" /MaxDrop="3.5628" /score="41.626335" /energy="-15.9" /TU="U2971,U2972" /idTUdmin="U2973" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(3381443) /Source="Nicolas_upshifts" /id="U2971" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=2703 /SigmaFactorBS="gttcgattcaacaagttttttcagcaaaagacaagaaaaTGG CATGATTCTTGCATTTttattcatatgcgaagatatatttcataacacgagggggact a" /listShort="rocA, rocB, rocC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3381445..3381625) /Source="Nicolas_S_feature" /locus_tag="new_3880559_3880739_c" /HighExp="S0, Lbstat, T1.30H, T2.0H, T1.0H, BI, T2.30H, M0t90, M40t90, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.864, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1460" misc_feature complement(3381446..3381464) /Source="Nicolas_upshift_promotors" /id="U2971" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=2703 /SigmaFactorBS="gttcgattcaacaagttttttcagcaaaagacaagaaaaTGG CATGATTCTTGCATTTttattcatatgcgaagatatatttcataacacgagggggact a" /listShort="rocA, rocB, rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3381626..3382900) /gene="rocG" /locus_tag="BSU_37790" /old_locus_tag="BSU37790" /EC_number="1.4.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9829940, 10468601, 12634342, 15150224, 17183217, 17608797, 18326565, 20630473, 22178969, 22625175, 25711804, 28193334" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829940, 10468601, 12634342, 15150224, 17183217, 17608797, 18326565, 20630473, 22178969, 22625175, 25711804, 28193334; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate dehydrogenase" /protein_id="NP_391659.2" /db_xref="EnsemblGenomes-Gn:BSU37790" /db_xref="EnsemblGenomes-Tr:CAB15806" /db_xref="GOA:P39633" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR014362" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR033922" /db_xref="InterPro:IPR036291" /db_xref="PDB:3K92" /db_xref="SubtiList:BG10621" /db_xref="UniProtKB/Swiss-Prot:P39633" /translation="MSAKQVSKDEEKEALNLFLSTQTIIKEALRKLGYPGDMYELMKE PQRMLTVRIPVKMDNGSVKVFTGYRSQHNDAVGPTKGGVRFHPEVNEEEVKALSIWMT LKCGIANLPYGGGKGGIICDPRTMSFGELERLSRGYVRAISQIVGPTKDIPAPDVYTN SQIMAWMMDEYSRLREFDSPGFITGKPLVLGGSQGRETATAQGVTICIEEAVKKKGIK LQNARIIIQGFGNAGSFLAKFMHDAGAKVIGISDANGGLYNPDGLDIPYLLDKRDSFG MVTNLFTDVITNEELLEKDCDILVPAAISNQITAKNAHNIQASIVVEAANGPTTIDAT KILNERGVLLVPDILASAGGVTVSYFEWVQNNQGYYWSEEEVAEKLRSVMVSSFETIY QTAATHKVDMRLAAYMTGIRKSAEASRFRGWV*" /label="rocG CDS" gene complement(3381626..3382900) /gene="rocG" /locus_tag="BSU_37790" /old_locus_tag="BSU37790" /label="rocG gene" S_feature complement(3382901..3382983) /Source="Nicolas_S_feature" /locus_tag="new_3882015_3882097_c" /HighExp="S0, Lbstat, T1.30H, T2.0H, T1.0H, BI, T2.30H, M0t90, M40t90, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.83780600000000005" /TUshortSig="SigL, SigA" /TUshortPSig="0.864, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1461" upshifts complement(3382983) /Source="Nicolas_upshifts" /id="U2972" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.864135864135864" /psig="0.864135864135864" /xcortree=393 /SigmaFactorBS="tcagtctctttttttgtggattcaaaagcTGGTACGGATCTT GCATGAtgataagggtgaatccaatgaagaaaggaattggcgggctgattttttaaag c" /listShort="S1461, rocG, S1460, rocA, rocB, rocC" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3382996..3383014) /Source="Nicolas_upshift_promotors" /id="U2972" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.864135864135864" /psig="0.864135864135864" /xcortree=393 /SigmaFactorBS="tcagtctctttttttgtggattcaaaagcTGGTACGGATCTT GCATGAtgataagggtgaatccaatgaagaaaggaattggcgggctgattttttaaag c" /listShort="S1461, rocG, S1460, rocA, rocB, rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(3383076) /Source="Nicolas_upshifts" /id="D1959" /incds=0 /nref=9 /ntot=144 /MaxReadThrough="4.82066" /MaxDrop="4.13762" /score="22.6949864" /energy="-11.4" /TU="U2973" /idTUdmin="U2977" /TUdmin=369 /isTUend="FALSE" /label="downshifts" CDS complement(3383077..3383541) /gene="bslB" /locus_tag="BSU_37800" /old_locus_tag="BSU37800" /experiment="publication(s) with functional evidences, PMID:15187182, 28751732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 28751732; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="biofilm protein, member of the processed secretome contributing to biofilm hydrophobicity" /protein_id="NP_391660.1" /db_xref="EnsemblGenomes-Gn:BSU37800" /db_xref="EnsemblGenomes-Tr:CAB15807" /db_xref="GOA:P39632" /db_xref="InterPro:IPR034650" /db_xref="PDB:5MKD" /db_xref="SubtiList:BG10620" /db_xref="UniProtKB/Swiss-Prot:P39632" /translation="MLKRTSFVSSLFISSAVLLSILLPSGQAHAQSASIEAKTVNSTK EWTISDIEVTYKPNAVLSLGAVEFQFPDGFHATTRDSVNGRTLKETQILNDGKTVRLP LTLDLLGASEFDLVMVRKTLPRAGTYTIKGDVVNGLGIGSFYAETQLVIDPR*" /label="bslB CDS" gene complement(3383077..3383541) /gene="bslB" /locus_tag="BSU_37800" /old_locus_tag="BSU37800" /label="bslB gene" S_feature complement(3383542..3383652) /Source="Nicolas_S_feature" /locus_tag="new_3882656_3882766_c" /HighExp="C90, S1, S0, MG 150, M9-tran, LPhT, BI, GM 150, Lbtran, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1462" promotor_-10 complement(3383634..3383653) /Source="Nicolas_upshift_promotors" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="promotor_-10" upshifts complement(3383652) /Source="Nicolas_upshifts" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="upshifts" promotor_-35 complement(3383668..3383675) /Source="Nicolas_upshift_promotors" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="promotor_-35" downshifts complement(3383863) /Source="Nicolas_upshifts" /id="D1960" /incds=0 /nref=32 /ntot=80 /MaxReadThrough="3.01999" /MaxDrop="4.92444" /score="6.35246869" /energy="-8.4" /TU="U2977" /idTUdmin="U2977" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" CDS complement(3383865..3384320) /gene="spsL" /locus_tag="BSU_37810" /old_locus_tag="BSU37810" /EC_number="5.1.3.13" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25239894; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP-4-deoxyrhamnose-3,5-epimerase (cell surface and spore coat)" /protein_id="YP_054595.1" /db_xref="EnsemblGenomes-Gn:BSU37810" /db_xref="EnsemblGenomes-Tr:CAE01469" /db_xref="GOA:Q7WY56" /db_xref="InterPro:IPR000888" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG14195" /db_xref="UniProtKB/Swiss-Prot:Q7WY56" /translation="MIDGVKVKKLMKHSDDRGFFAELVRDDENLLEHFGQASWSKSYP GVIKAFHYHEKQDDLWFFPTGHAQVVLYDLREDSKTKGETDVYYMGEDNPMLLLIPKG VAHGYRVLGETPLTIIYFTTMSYNPDQPDEKRIPWDDETIGFNWNTEFR*" /label="spsL CDS" gene complement(3383865..3384320) /gene="spsL" /locus_tag="BSU_37810" /old_locus_tag="BSU37810" /label="spsL gene" misc_feature 3383955..3383974 /Source="Nicolas_upshift_promotors" /id="U2974" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2855 /SigmaFactorBS="catcatcccacggaattcttttttcatcaggctgatccgggt tatacgacatGGTGGTAAAATAGATAATTGtcagcggcgtctctcccagcactctata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3383963 /Source="Nicolas_upshifts" /id="U2974" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2855 /SigmaFactorBS="catcatcccacggaattcttttttcatcaggctgatccgggt tatacgacatGGTGGTAAAATAGATAATTGtcagcggcgtctctcccagcactctata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3384313..3385164) /gene="spsK" /locus_tag="BSU_37820" /old_locus_tag="BSU37820" /EC_number="1.1.1.133" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP-4-dehydrorhamnose reductase" /protein_id="NP_391661.3" /db_xref="EnsemblGenomes-Gn:BSU37820" /db_xref="EnsemblGenomes-Tr:CAB15808" /db_xref="GOA:P39631" /db_xref="InterPro:IPR005913" /db_xref="InterPro:IPR029903" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10619" /db_xref="UniProtKB/Swiss-Prot:P39631" /translation="MTKVLVTGAGGQLGLELCRQLKQAGYEVIALTKKMMNIADQRSV RHSFGHYQPDIVVNSAAFTSVDQCEKELDKAYLINGIGAYYTALESTRIGAQYVHIST DYVFNGKGTQPYREDDPLDPKTIYGKSKRLGEELIRLTTKDSTIIRTSWVYGHGGSNF VETMLKLAETKQELRVVSDQIGSPTYTKDLAEAVIKLFSHPPGIYHVSNSGICSWYEF ATAIMEESGLETAILSVTTEEYGNKTPRPAYSVLSHRAIEEAGIRPRHWREALREYLQ ERSSACD*" /label="spsK CDS" gene complement(3384313..3385164) /gene="spsK" /locus_tag="BSU_37820" /old_locus_tag="BSU37820" /label="spsK gene" CDS complement(3385178..3386125) /gene="spsJ" /locus_tag="BSU_37830" /old_locus_tag="BSU37830" /EC_number="4.2.1.46" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:22960854" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dTDP-glucose 4,6-dehydratase" /protein_id="NP_391662.1" /db_xref="EnsemblGenomes-Gn:BSU37830" /db_xref="EnsemblGenomes-Tr:CAB15809" /db_xref="GOA:P39630" /db_xref="InterPro:IPR005888" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10618" /db_xref="UniProtKB/Swiss-Prot:P39630" /translation="MAKSYLITGGAGFIGLTFTKLMLRETDARITVLDKLTYASHPEE MEKLKQNSRFRFVKGDISVQEDIDRAFDETYDGVIHFAAESHVDRSISQAEPFITTNV MGTYRLAEAVLKGKAKKLIHISTDEVYGDLKADDPAFTETTPLSPNNPYSASKASSDL LVLSYVKTHKLPAIITRCSNNYGPYQHSEKMIPTIIRHAKQGLPVPLYGDGLQIRDWL FAEDHCRAIKLILEKGTDGEVYNIGGGNERTNKELASVILKHLGCEELFAHVEDRKGH DRRYAINASKLKNELGWRQEVTFEEGIARTIQWYTDNDR*" /label="spsJ CDS" gene complement(3385178..3386125) /gene="spsJ" /locus_tag="BSU_37830" /old_locus_tag="BSU37830" /label="spsJ gene" CDS complement(3386125..3386865) /gene="spsI" /locus_tag="BSU_37840" /old_locus_tag="BSU37840" /EC_number="2.7.7.24" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:22960854" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate thymidylyltransferase" /protein_id="NP_391663.1" /db_xref="EnsemblGenomes-Gn:BSU37840" /db_xref="EnsemblGenomes-Tr:CAB15810" /db_xref="GOA:P39629" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005907" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10617" /db_xref="UniProtKB/Swiss-Prot:P39629" /translation="MKGVILAGGNGSRLMPLTKAVNKHLLPVGPYPMIYWSIMKLQEA GIKDILLISQKEHMPQFYKLLGNGEELGVTITYQVQPAASGISDGLSYAKRFTKKESF ILLLGDNIFEDSLKPYTERFEQQGKGAKVLLKEVDDPERFGIAEIDEKNKRIRSIIEK PEQPPTNLCVTGIYMYDAEVFSYIEQISPSKRGELEITDVNNLYIENSQLTYDVLSGW WVDAGTHESLYLASQLVHQALRKGQDEK*" /label="spsI CDS" gene complement(3386125..3386865) /gene="spsI" /locus_tag="BSU_37840" /old_locus_tag="BSU37840" /label="spsI gene" promotor_-35 3386883..3386888 /Source="Nicolas_upshift_promotors" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3386889 /Source="Nicolas_upshifts" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3386890..3387909) /gene="spsG" /locus_tag="BSU_37850" /old_locus_tag="BSU37850" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391664.1" /db_xref="EnsemblGenomes-Gn:BSU37850" /db_xref="EnsemblGenomes-Tr:CAB15811" /db_xref="GOA:P39627" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG10615" /db_xref="UniProtKB/Swiss-Prot:P39627" /translation="MHVGIFADGGYEKGMGHVVRMKRLAEGLKQRCLITFYTNQDSEA FLHEEHWQVIVKPELQQHEFILREIKSKKLDLLLFDILGAPAELLKKIKTETDAKIVL FEEKNGKSIQYSDAVINGIYGDIRSRVYVQGNTRIYEGPDYLILHPAFQAAREDYTLK KDCRNILVALGGSDPKQLIFKVLAAADQVPDIKDKNMMFVMGSASPHQEAVRRRIEKK PQYKMIEQTNDMAGLMKQADAAIVAGGISLYEAICIGVPCLVLSQVEHQTATAKTFAD QGAALDLGLGELVPDETLIYQMSRIMSSYPLRLSLHKGGRPLVDGKGIIRVTAILQDL YEQEI*" /label="spsG CDS" gene complement(3386890..3387909) /gene="spsG" /locus_tag="BSU_37850" /old_locus_tag="BSU37850" /label="spsG gene" promotor_-10 3386903..3386921 /Source="Nicolas_upshift_promotors" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3387773..3387782 /Source="Nicolas_upshift_promotors" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3387795..3387810 /Source="Nicolas_upshift_promotors" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3387806 /Source="Nicolas_upshifts" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3387912..3388634) /gene="spsF" /locus_tag="BSU_37860" /old_locus_tag="BSU37860" /EC_number="2.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391665.2" /db_xref="EnsemblGenomes-Gn:BSU37860" /db_xref="EnsemblGenomes-Tr:CAB15812" /db_xref="InterPro:IPR003329" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10614" /db_xref="UniProtKB/Swiss-Prot:P39626" /translation="MNDILFIIQARMGSTRLPGKVLRPLGSNRLLDILVHRVRQSAFY QKDRDNLVIATSDKETDDILEAHCIKQGFRVFRGSEERVLDRFVKVIEAVKPSVIIRL TGDNPFVDPELLDVMIQAHFDQGSDYTYILNAPLGICGEVVNANLLIDISRIQALEDQ YQEHVTLYIRNHPALYRVQFLEAPERFRAPQYRLTIDTKEDYESIKALYQKAGERPDV SASELITLLNRNPDAATEREAD*" /label="spsF CDS" gene complement(3387912..3388634) /gene="spsF" /locus_tag="BSU_37860" /old_locus_tag="BSU37860" /label="spsF gene" CDS complement(3388627..3389748) /gene="spsE" /locus_tag="BSU_37870" /old_locus_tag="BSU37870" /EC_number="2.5.-.-" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12597896, 15774001; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoenolpyruvate-sugar pyruvyltransferase" /protein_id="NP_391666.1" /db_xref="EnsemblGenomes-Gn:BSU37870" /db_xref="EnsemblGenomes-Tr:CAB15813" /db_xref="GOA:P39625" /db_xref="InterPro:IPR006190" /db_xref="InterPro:IPR013132" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR013974" /db_xref="InterPro:IPR036732" /db_xref="PDB:1VLI" /db_xref="SubtiList:BG10613" /db_xref="UniProtKB/Swiss-Prot:P39625" /translation="MAAFQIANKTVGKDAPVFIIAEAGINHDGKLDQAFALIDAAAEA GADAVKFQMFQADRMYQKDPGLYKTAAGKDVSIFSLVQSMEMPAEWILPLLDYCREKQ VIFLSTVCDEGSADLLQSTSPSAFKIASYEINHLPLLKYVARLNRPMIFSTAGAEISD VHEAWRTIRAEGNNQIAIMHCVAKYPAPPEYSNLSVIPMLAAAFPEAVIGFSDHSEHP TEAPCAAVRLGAKLIEKHFTIDKNLPGADHSFALNPDELKEMVDGIRKTEAELKQGIT KPVSEKLLGSSYKTTTAIEGEIRNFAYRGIFTTAPIQKGEAFSEDNIAVLRPGQKPQG LHPRFFELLTSGVRAVRDIPADTGIVWDDILLKDSPFHE*" /label="spsE CDS" gene complement(3388627..3389748) /gene="spsE" /locus_tag="BSU_37870" /old_locus_tag="BSU37870" /label="spsE gene" CDS complement(3389748..3390617) /gene="spsD" /locus_tag="BSU_37880" /old_locus_tag="BSU37880" /EC_number="2.3.1.-" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative TDP-glycosamine N-acetyltransferase" /protein_id="NP_391667.1" /db_xref="EnsemblGenomes-Gn:BSU37880" /db_xref="EnsemblGenomes-Tr:CAB15814" /db_xref="GOA:P39624" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10612" /db_xref="UniProtKB/Swiss-Prot:P39624" /translation="MYTVKENVSKEAIEEFLQSRKLTLDVPYQFSLGLFENSRLQGVL LYEDSLWESKVLQKKVMNVKLLAANSTGQLKRLFEAFYTVRQMDETDFIFVRVPAEDI GAAHVIQQQPSSYFVGSLLKLAMPPSFYDKTPPFFELGPPEPGDTEAICELARDSFTK SRYFQDPHLSRDAANEIFQEWTRNNLNGRAAVNIVAKHNGEVIGYLQGLSRDDECILD LMAVKPGFEGKRIAFHLLANLIEQPETQKHRTVTAGTQLHNVRAIRLYERMGFTAEQS YYYYHIWPGKEAK*" /label="spsD CDS" gene complement(3389748..3390617) /gene="spsD" /locus_tag="BSU_37880" /old_locus_tag="BSU37880" /label="spsD gene" CDS complement(3390618..3391787) /gene="spsC" /locus_tag="BSU_37890" /old_locus_tag="BSU37890" /EC_number="2.6.1.-" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14602648; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glutamine-dependent sugar transaminase" /protein_id="NP_391668.1" /db_xref="EnsemblGenomes-Gn:BSU37890" /db_xref="EnsemblGenomes-Tr:CAB15815" /db_xref="GOA:P39623" /db_xref="InterPro:IPR000653" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10611" /db_xref="UniProtKB/Swiss-Prot:P39623" /translation="MVQKRNHFLPYSLPLIGKEEIQEVTETLESGWLSKGPKVQQFEK EFAAFVGAKHAVAVNSCTAALFLALKAKGIGPGDEVITSPLTFSSTANTIIHTGATPV FADIDENTLNIDPVKLEAAVTPRTKAVVPVHFGGQSCDMDAILAVAQNHGLFVLEDAA HAVYTTYKQRMIGSIGDATAFSFYATKNLATGEGGMLTTDDEELADKIRVLSLHGMSK AAWNRYSSNGSWYYEVESPGYKMNMFDLQAALGLHQLKRLDDMQKRREEIAGRYQTAF QQIPGLITPFVHDDGRHAWHLYVLQVDEKKAGVTRSEMITALKDEYNIGTSVHFIPVH IHPYYQKQFGYKEADFPNAMNYYKRTLSLPLYPSMSDDDVDDVIEAVRDIVKGAD*" /label="spsC CDS" gene complement(3390618..3391787) /gene="spsC" /locus_tag="BSU_37890" /old_locus_tag="BSU37890" /label="spsC gene" CDS complement(3391808..3393232) /gene="spsB" /locus_tag="BSU_37900" /old_locus_tag="BSU37900" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22611084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP glycosyl/glycerophosphate transferase or transport" /protein_id="NP_391669.2" /db_xref="EnsemblGenomes-Gn:BSU37900" /db_xref="EnsemblGenomes-Tr:CAB15816" /db_xref="GOA:P39622" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10610" /db_xref="UniProtKB/Swiss-Prot:P39622" /translation="MSAYLSNYWVLYRKYVELFDKLRYKGIPLGLISNFYQYISPELR VMMEEEPELFGSVDQHIDEGQIQPFFEERIQNIVKTNDEPVKGKVILHFDYLRFSNEN YYQFDPEKTAVLARWSLPHYCDLPVISKREIADSCQKGDSKQYLETACSLLAPYDDHP AFGDQAFRDRLFKDIPLFIEAIDTVDALFEQEKISAVIVGTAEDIYSRVLALMCQRKG AVSICLQHGALMGDEAFIPVFTTYQAVFGAYEAEWFIRKGCKPEQILVTGHPRFDQIF NRTPMDMSIFYRKLAFQPTKKIVLIATQPFSEDFYSGVLQGLSDQKQLQIIIKPHPWE IGKNKLDLYHEAAKKHQACRVIKKELELYDLLPYVDAAVTQTSTVGLEAMLFQKPVLI GKSSGNRSYPYYESLGDFMFDQPDELAHTLVEVLRSPDVHQKAEEARLAFIAANYPVA ESTNALFAELKAKTGVDYRREDTE*" /label="spsB CDS" gene complement(3391808..3393232) /gene="spsB" /locus_tag="BSU_37900" /old_locus_tag="BSU37900" /label="spsB gene" CDS complement(3393237..3394007) /gene="spsA" /locus_tag="BSU_37910" /old_locus_tag="BSU37910" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10350455, 11042447, 11733986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10350455, 11042447, 11733986; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat dTDP-glycosyltransferase" /protein_id="NP_391670.1" /db_xref="EnsemblGenomes-Gn:BSU37910" /db_xref="EnsemblGenomes-Tr:CAB15817" /db_xref="GOA:P39621" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="PDB:1H7L" /db_xref="PDB:1H7Q" /db_xref="PDB:1QG8" /db_xref="PDB:1QGQ" /db_xref="PDB:1QGS" /db_xref="SubtiList:BG10609" /db_xref="UniProtKB/Swiss-Prot:P39621" /translation="MPKVSVIMTSYNKSDYVAKSISSILSQTFSDFELFIMDDNSNEE TLNVIRPFLNDNRVRFYQSDISGVKERTEKTRYAALINQAIEMAEGEYITYATDDNIY MPDRLLKMVRELDTHPEKAVIYSASKTYHLNENRDIVKETVRPAAQVTWNAPCAIDHC SVMHRYSVLEKVKEKFGSYWDESPAFYRIGDARFFWRVNHFYPFYPLDEELDLNYITD QSIHFQLFELEKNEFVRNLPPQRNCRELRESLKKLGMG*" /label="spsA CDS" gene complement(3393237..3394007) /gene="spsA" /locus_tag="BSU_37910" /old_locus_tag="BSU37910" /label="spsA gene" promotor_-10 complement(3394042..3394061) /Source="Nicolas_upshift_promotors" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3394056) /Source="Nicolas_upshifts" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3394075..3394084) /Source="Nicolas_upshift_promotors" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3394175..3394180 /Source="Nicolas_upshift_promotors" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3394196..3394214 /Source="Nicolas_upshift_promotors" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3394198..3394326 /Source="Nicolas_S_feature" /locus_tag="new_3893312_3893440" /HighExp="S5, S4, S3, S7, B36, S8, S6, B60, T5.0H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1463" upshifts 3394198 /Source="Nicolas_upshifts" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="upshifts" CDS 3394327..3394872 /gene="gerQ" /locus_tag="BSU_37920" /old_locus_tag="BSU37920" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12644503, 15317760, 16936016, 16936016, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12644503, 15317760, 16936016, 16936016, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391671.1" /db_xref="EnsemblGenomes-Gn:BSU37920" /db_xref="EnsemblGenomes-Tr:CAB15818" /db_xref="GOA:P39620" /db_xref="InterPro:IPR014099" /db_xref="SubtiList:BG10608" /db_xref="UniProtKB/Swiss-Prot:P39620" /translation="MKPKKNQYQQMQAFDNMQGYQPQFGANPYPQQGQGSQMQTMGMQ PMMPMQQGQQGQQGQQGFGFPGQQQGGGFQIPSGPTPSGPGQSVPGMLPVEESYIENI LRLNRGKTATIYMTFENSKEWGSKIFRGVIEAAGRDHIIISDPKSGTRYLLLTIYLDY ITFDEEIAYTYPYSMASYSPR*" /label="gerQ CDS" gene 3394327..3394872 /gene="gerQ" /locus_tag="BSU_37920" /old_locus_tag="BSU37920" /label="gerQ gene" downshifts 3394858 /Source="Nicolas_upshifts" /id="D1961" /incds=0 /nref=60 /ntot=77 /MaxReadThrough="1.98659" /MaxDrop="7.96105" /score="16.9179802" /energy="-11.7" /TU="NA" /idTUdmin="U2978" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3394916..3395287) /gene="ywdK" /locus_tag="BSU_37930" /old_locus_tag="BSU37930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15919996, 21810204; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_391672.2" /db_xref="EnsemblGenomes-Gn:BSU37930" /db_xref="EnsemblGenomes-Tr:CAB15819" /db_xref="GOA:P39619" /db_xref="InterPro:IPR006696" /db_xref="SubtiList:BG10607" /db_xref="UniProtKB/Swiss-Prot:P39619" /translation="MKVFIILGAINALLAVGLGAFGAHGLEGKIPDKYLQVWHTGVQY HMYHALGLFVVAFLADKLSGIGSVTTAGWLMFAGIVLFSGSLYILSVTQISILGAITP LGGVAFIISWIMIVVAAVKYL*" /label="ywdK CDS" gene complement(3394916..3395287) /gene="ywdK" /locus_tag="BSU_37930" /old_locus_tag="BSU37930" /label="ywdK gene" downshifts complement(3394934) /Source="Nicolas_upshifts" /id="D1962" /incds=0 /nref=134 /ntot=227 /MaxReadThrough="3.65585" /MaxDrop="4.84049" /score="15.105437" /energy="-11.7" /TU="NA" /idTUdmin="U2979" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3395349..3396671) /gene="ywdJ" /locus_tag="BSU_37940" /old_locus_tag="BSU37940" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative purine/pyrimidine permease" /protein_id="NP_391673.2" /db_xref="EnsemblGenomes-Gn:BSU37940" /db_xref="EnsemblGenomes-Tr:CAB15820" /db_xref="GOA:P39618" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="SubtiList:BG10606" /db_xref="UniProtKB/Swiss-Prot:P39618" /translation="MKLVLGALQWTAFIIAAAIVVPVAVAQSFHLDHSDSARLIQSTF FVLGIAAVIQCLKGHRLPINESPAGLWWGVYTIYAGLTGTVFATYGDTLRGLQGALLV SAVCFFLLSVFKVIDRLAKLFTPVVTGVYLLLLVMQLSQPIIKGILGIGYRQDGVDGL VFGLALVVIAAAFIMTNSNIMFFKQYSILLALFGGWVLFAAAGAAKPIEMPDRLFQLP SLFPFGTPLFNSGLIITSIFITILLIVNMLASMKVVDIAMKKFSKQPDGKHHERHAGF AASFSHLLSGLTGAIAPVPISGAAGFIETTKMPSKKPFMLGSILVIVISVIPFFMNTF ASLPSPVGFAVNFVVFSAMGGLAFAEFDSYEKEESKRVRSIIGISLLTGVGIMFVPET ALKGLHPVFISLLSNGLVLGTLAAIAADQFQLWRRRKSDNLVSTENKH*" /label="ywdJ CDS" gene complement(3395349..3396671) /gene="ywdJ" /locus_tag="BSU_37940" /old_locus_tag="BSU37940" /label="ywdJ gene" CDS complement(3396691..3397008) /gene="ywdI" /locus_tag="BSU_37950" /old_locus_tag="BSU37950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391674.3" /db_xref="EnsemblGenomes-Gn:BSU37950" /db_xref="EnsemblGenomes-Tr:CAB15821" /db_xref="InterPro:IPR035218" /db_xref="SubtiList:BG10605" /db_xref="UniProtKB/Swiss-Prot:P39617" /translation="MNIHISALIQKMEEELKKAKTAERDEELKRYVAVVRSLCDVVLD QPENASAPRIQPSVTPSPAAPPSTDQLMMEKMMGSAGLNKYRKQEKEKQEEDGNGESL FDF*" /label="ywdI CDS" gene complement(3396691..3397008) /gene="ywdI" /locus_tag="BSU_37950" /old_locus_tag="BSU37950" /label="ywdI gene" promotor_-10 complement(3397037..3397056) /Source="Nicolas_upshift_promotors" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3397048) /Source="Nicolas_upshifts" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3397070..3397076) /Source="Nicolas_upshift_promotors" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3397111..3397118 /Source="Nicolas_upshift_promotors" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3397134..3397153 /Source="Nicolas_upshift_promotors" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3397137 /Source="Nicolas_upshifts" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="upshifts" CDS 3397176..3398546 /gene="ywdH" /locus_tag="BSU_37960" /old_locus_tag="BSU37960" /EC_number="1.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391675.2" /db_xref="EnsemblGenomes-Gn:BSU37960" /db_xref="EnsemblGenomes-Tr:CAB15822" /db_xref="GOA:P39616" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG10604" /db_xref="UniProtKB/Swiss-Prot:P39616" /translation="MNSIPSIISKHKAYFAAGHTRPLESRLNILRKLKQAVRTHEADL IAALYQDLHKSEQEAYSTEIGIVLEEISFVMKRLRKWSKPKRVKTPLTHLGSKSIIIP EPYGTVLVIAPWNYPLQLALSPLIGAIAAGNTVVLKPSEYTPAVSAILSKLISSVFPT DYVAMAEGGPDVSTALLQQPFDYIFFTGSVAVGKIVMEAAAKQLIPVTLELGGKSPCI VHKDADIQLAAKRIVFGKFTNAGQTCIAPDYLFVHEDIKTKLTEEMKRAIREFYGPQP ERNPQYGKIVSERHYQRLLSFLNDGIPLTGGQSDPNHHKIAPTILEQVRDDSPVMQEE IFGPILPLFTYRNIGEVIEKVQSRPKPLALYLFTTNKEIERAVLGNLSFGGGCVNDTL MHVATPYLPFGGVGESGIGSYHGFDSFNTFTHKKSVVKQTNRFDFAFRYPSSKNGLRM IRKILK*" /label="ywdH CDS" gene 3397176..3398546 /gene="ywdH" /locus_tag="BSU_37960" /old_locus_tag="BSU37960" /label="ywdH gene" CDS complement(3398571..3399248) /gene="ung" /locus_tag="BSU_37970" /old_locus_tag="BSU37970" /EC_number="3.2.2.27" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1902430, 9776748, 10080896, 21542855, 22056936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1902430, 9776748, 10080896, 21542855, 22056936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uracil-DNA glycosylase" /protein_id="NP_391676.1" /db_xref="EnsemblGenomes-Gn:BSU37970" /db_xref="EnsemblGenomes-Tr:CAB15823" /db_xref="GOA:P39615" /db_xref="InterPro:IPR002043" /db_xref="InterPro:IPR005122" /db_xref="InterPro:IPR018085" /db_xref="InterPro:IPR036895" /db_xref="PDB:3ZOQ" /db_xref="PDB:3ZOR" /db_xref="SubtiList:BG10603" /db_xref="UniProtKB/Swiss-Prot:P39615" /translation="MKQLLQDSWWNQLKEEFEKPYYQELREMLKREYAEQTIYPDSRD IFNALHYTSYDDVKVVILGQDPYHGPGQAQGLSFSVKPGVKQPPSLKNIFLELQQDIG CSIPNHGSLVSWAKQGVLLLNTVLTVRRGQANSHKGKGWERLTDRIIDVLSERERPVI FILWGRHAQMKKERIDTSKHFIIESTHPSPFSARNGFFGSRPFSRANAYLEKMGEAPI DWCIKDL*" /label="ung CDS" gene complement(3398571..3399248) /gene="ung" /locus_tag="BSU_37970" /old_locus_tag="BSU37970" /label="ung gene" downshifts complement(3398585) /Source="Nicolas_upshifts" /id="D1963" /incds=0 /nref=66 /ntot=224 /MaxReadThrough="2.25259" /MaxDrop="4.72154" /score="26.8023311" /energy="-9.1" /TU="NA" /idTUdmin="U2982" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3399075..3399094) /Source="Nicolas_upshift_promotors" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3399091) /Source="Nicolas_upshifts" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3399110..3399115) /Source="Nicolas_upshift_promotors" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3399262..3400068) /gene="ywdF" /locus_tag="BSU_37980" /old_locus_tag="BSU37980" /EC_number="2.4.-.-" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9334165; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391677.1" /db_xref="EnsemblGenomes-Gn:BSU37980" /db_xref="EnsemblGenomes-Tr:CAB15824" /db_xref="GOA:P39614" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10602" /db_xref="UniProtKB/Swiss-Prot:P39614" /translation="MKISIVIVTYNRIPALCELLESISRQTLMPYEIIIVNDAGESVV PVKALYPELPIAVINLEKNSGHVAARNAGVKEASGDCIMLCDDDDFFTPGHIEKMAKE IETADFVHSDAEIVSFEEKNGTRYPVSRKLFAYTADYEDMRVFSTYVPSGSMYRRFLH DEIGYFDADVHNYWDWDFYLRAAKDYRVKRVPCASVIYAFSDAGDNQSADLGAKRKQY LDRLSEKHGLGELPTKNFAVLLEEPEMKRREAKSEMVWDGEPVYSRLHRS*" /label="ywdF CDS" gene complement(3399262..3400068) /gene="ywdF" /locus_tag="BSU_37980" /old_locus_tag="BSU37980" /label="ywdF gene" promotor_-10 complement(3399561..3399579) /Source="Nicolas_upshift_promotors" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3399575) /Source="Nicolas_upshifts" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3399594..3399600) /Source="Nicolas_upshift_promotors" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3400097..3400116) /Source="Nicolas_upshift_promotors" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3400103) /Source="Nicolas_upshifts" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3400132..3400139) /Source="Nicolas_upshift_promotors" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3400158..3400691) /gene="ywdE" /locus_tag="BSU_37990" /old_locus_tag="BSU37990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391678.1" /db_xref="EnsemblGenomes-Gn:BSU37990" /db_xref="EnsemblGenomes-Tr:CAB15825" /db_xref="GOA:P39613" /db_xref="SubtiList:BG10601" /db_xref="UniProtKB/Swiss-Prot:P39613" /translation="MRISSCLYGFVAHGAVFLFTGGCMLLAMAASLPFVFLLDRLPDV VFTAGAILTLLCSYAYVWFWAVRFAYNQKMRLFEVQLGSFVLLALMISLFLLDGSSMK DIMMNWDDAGCAFVPPAFTFLCLSYALVLLPVYQSKLWRLILPNGVRMKDIFHVFGDL MLIMVLLIGATLLFLSL*" /label="ywdE CDS" gene complement(3400158..3400691) /gene="ywdE" /locus_tag="BSU_37990" /old_locus_tag="BSU37990" /label="ywdE gene" CDS complement(3400739..3401374) /gene="ywdD" /locus_tag="BSU_38000" /old_locus_tag="BSU38000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391679.2" /db_xref="EnsemblGenomes-Gn:BSU38000" /db_xref="EnsemblGenomes-Tr:CAB15826" /db_xref="GOA:P39612" /db_xref="SubtiList:BG10600" /db_xref="UniProtKB/Swiss-Prot:P39612" /translation="MDKETYVSEIKSGLKGLPEGEAMIEEIESHIEHHLFRSFQEGKS EEEAMQTLLQAFGTPTDIVSSFKKIQPVTFRAFLMFHLFCNSALFAVGIAITIMHVWL ESPFVQAVWKGISVSVWLILAAYMIYWVLIGYQGVKEFGKRGEKLVLHTILISMVPNV IFMLVFLFNVIPAALFQSLLTPWFVGTCAFATLLFPLFGRMGCYIGRRQLV*" /label="ywdD CDS" gene complement(3400739..3401374) /gene="ywdD" /locus_tag="BSU_38000" /old_locus_tag="BSU38000" /label="ywdD gene" CDS complement(3401367..3401705) /gene="ywzG" /locus_tag="BSU_38018" /old_locus_tag="BSU38018" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator, PadR family" /protein_id="YP_003097793.1" /db_xref="EnsemblGenomes-Gn:BSU38018" /db_xref="EnsemblGenomes-Tr:CAX52706" /db_xref="GOA:C0H3S6" /db_xref="InterPro:IPR005149" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3S6" /translation="MLNRELVKGSTVILVLTLLNERPMYGYELVKEMGSRSGNELQMK EGTLYPSLHKLERQGYISSYWEKQEKGPDRKYYRITDEGKEVLAERTKEWSVFSAMMD RILKWSGQNG*" /label="ywzG CDS" gene complement(3401367..3401705) /gene="ywzG" /locus_tag="BSU_38018" /old_locus_tag="BSU38018" /label="ywzG gene" promotor_-10 complement(3401727..3401746) /Source="Nicolas_upshift_promotors" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3401738) /Source="Nicolas_upshifts" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3401761..3401768) /Source="Nicolas_upshift_promotors" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3401789..3401792 /Source="Nicolas_upshift_promotors" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3401807..3401826 /Source="Nicolas_upshift_promotors" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3401807 /Source="Nicolas_upshifts" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="upshifts" CDS 3401849..3402664 /gene="pdxK" /locus_tag="BSU_38020" /old_locus_tag="BSU38020" /EC_number="2.7.1.35" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14973012, 17012797" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14973012, 17012797; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyridoxine, pyridoxal, and pyridoxamine kinase" /protein_id="NP_391681.1" /db_xref="EnsemblGenomes-Gn:BSU38020" /db_xref="EnsemblGenomes-Tr:CAB15828" /db_xref="GOA:P39610" /db_xref="InterPro:IPR004399" /db_xref="InterPro:IPR013749" /db_xref="InterPro:IPR029056" /db_xref="PDB:2I5B" /db_xref="SubtiList:BG10598" /db_xref="UniProtKB/Swiss-Prot:P39610" /translation="MSMHKALTIAGSDSSGGAGIQADLKTFQEKNVYGMTALTVIVAM DPNNSWNHQVFPIDTDTIRAQLATITDGIGVDAMKTGMLPTVDIIELAAKTIKEKQLK NVVIDPVMVCKGANEVLYPEHAQALREQLAPLATVITPNLFEASQLSGMDELKTVDDM IEAAKKIHALGAQYVVITGGGKLKHEKAVDVLYDGETAEVLESEMIDTPYTHGAGCTF SAAVTAELAKGAEVKEAIYAAKEFITAAIKESFPLNQYVGPTKHSALRLNQQS*" /label="pdxK CDS" gene 3401849..3402664 /gene="pdxK" /locus_tag="BSU_38020" /old_locus_tag="BSU38020" /label="pdxK gene" downshifts 3402643 /Source="Nicolas_upshifts" /id="D1964" /incds=0 /nref=185 /ntot=251 /MaxReadThrough="2.56759" /MaxDrop="5.39956" /score="22.0760698" /energy="-18.1" /TU="NA" /idTUdmin="U2985" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3402719) /Source="Nicolas_upshifts" /id="D1965" /incds=0 /nref=20 /ntot=111 /MaxReadThrough="0.56945" /MaxDrop="6.81686" /score="39.7901804" /energy="-16.8" /TU="NA" /idTUdmin="U2987" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3402754..3403002) /gene="ywdA" /locus_tag="BSU_38030" /old_locus_tag="BSU38030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391682.1" /db_xref="EnsemblGenomes-Gn:BSU38030" /db_xref="EnsemblGenomes-Tr:CAB15829" /db_xref="SubtiList:BG10597" /db_xref="UniProtKB/Swiss-Prot:P39609" /translation="MNIHEQKITPECLEKAANQVEDKREEYKDVLLQLKKMLGGTTPH SETAEILTRAYEQMKEYALFVQSIETFLRKSANNLKIK*" /label="ywdA CDS" gene complement(3402754..3403002) /gene="ywdA" /locus_tag="BSU_38030" /old_locus_tag="BSU38030" /label="ywdA gene" downshifts complement(3402774) /Source="Nicolas_upshifts" /id="D1966" /incds=0 /nref=6 /ntot=123 /MaxReadThrough="6.75845" /MaxDrop="3.89221" /score="22.6408081" /energy="-10.8" /TU="U2987,U2988" /idTUdmin="U2986" /TUdmin=11 /isTUend="TRUE" /label="downshifts" upshifts complement(3403020) /Source="Nicolas_upshifts" /id="U2986" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.211788211788212" /psig="0.230769230769231" /xcortree=577 /SigmaFactorBS="tcttatgtgaaatctgagccatctgtgctattcttcaacgat aaCCTACTAtttttttctgtaaaaggagttgttttcttgaatatacatgaacagaaga t" /listShort="ywdA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3403022..3403095) /Source="Nicolas_S_feature" /locus_tag="new_3902136_3902209_c" /HighExp="G150, Mt0, Diami, Lbexp, dia0, dia5, T0.30H, Oxctl, Etha, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.536, 0.743, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1464" misc_feature complement(3403030..3403036) /Source="Nicolas_upshift_promotors" /id="U2986" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.211788211788212" /psig="0.230769230769231" /xcortree=577 /SigmaFactorBS="tcttatgtgaaatctgagccatctgtgctattcttcaacgat aaCCTACTAtttttttctgtaaaaggagttgttttcttgaatatacatgaacagaaga t" /listShort="ywdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3403096..3404535) /gene="sacA" /locus_tag="BSU_38040" /old_locus_tag="BSU38040" /EC_number="3.2.1.26" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 3100393; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sucrose-6-phosphate hydrolase" /protein_id="NP_391683.2" /db_xref="EnsemblGenomes-Gn:BSU38040" /db_xref="EnsemblGenomes-Tr:CAB15830" /db_xref="GOA:P07819" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR006232" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018053" /db_xref="InterPro:IPR023296" /db_xref="SubtiList:BG10596" /db_xref="UniProtKB/Swiss-Prot:P07819" /translation="MTAHDQELRRRAYEEVEKKEPIANSDPHRQHFHIMPPVGLLNDP NGVIYWKGSYHVFFQWQPFQTGHGAKFWGHYTTQDVVNWKREEIALAPSDWFDKNGCY SGSAVTKDDRLYLFYTGNVRDQDGNRETYQCLAVSDDGLSFEKKGVVARLPEGYTAHF RDPKVWEHEGTWYMVIGAQTENLKGQAVLFASDNLTEWRFLGPITGAGFNGLDDFGYM WECPDLFSLQGSDVLIVSPQGLEADGFRYQNVYQSGYFVGRLDYNKPELKHGEFTELD QGFDFYAPQTLEDDQGRRILFAWMAVPDQDEGSHPTIDCHWIHCMTLPRQLTLSGQKL IQQPLPELKAMRRNEKKIHINMHGSSGALPVEKPERTEILLEDIHTESGFSISIRGTA TFSFHKDEGIVTLERKSFDGKRTEARHCRIKDLHTVHMFLDASSVEIFINNGEEVLSA RYFPFPGNHEVTASATGKSEMNVGIWTLM*" /label="sacA CDS" gene complement(3403096..3404535) /gene="sacA" /locus_tag="BSU_38040" /old_locus_tag="BSU38040" /label="sacA gene" CDS complement(3404532..3405917) /gene="sacP" /locus_tag="BSU_38050" /old_locus_tag="BSU38050" /EC_number="2.7.1.211" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1577686, 3122206, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1577686, 3122206, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) sucrose-specificenzyme IIBC component" /protein_id="NP_391684.3" /db_xref="EnsemblGenomes-Gn:BSU38050" /db_xref="EnsemblGenomes-Tr:CAB15831" /db_xref="GOA:P05306" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR010973" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10595" /db_xref="UniProtKB/Swiss-Prot:P05306" /translation="MDYKETAKRLIELLGGKENIISAAHCATRLRLVMKDESKIDQAQ VEELDGVKGAFSSSGQYQIIFGTGLVNKVFDAFSKEADIEREEHVNHQDAAKEKLNPA ARFAKTLSNIFVPIIPAIVASGLLMGLLGMINAFHWMSKDSALLQLLDMFSSAAFIFL PILIGVSASKEFGSNPYLGAVIGGIMIHPNLLNPWGLAEATPDYMHLFGFDIALLGYQ GTVIPVLLAVYVMSKVEKWTRKVVPHAVDLLVTPFVTVIVTGFVAFIAIGPLGRALGS GITVALTYVYDHAGFVAGLIFGGTYSLIVLTGVHHSFHAIEAGLIADIGKNYLLPIWS MANVAQGGAGLAVFFMAKKAKTKEIALPAAFSAFLGITEPVIFGVNLRYRKPFIAAMI GGALGGAYVVFTHVAANAYGLTGIPMIAIAAPFGFSNLIHYLIGMAIAAVSAFIAAFV MKINEDEERKK*" /label="sacP CDS" gene complement(3404532..3405917) /gene="sacP" /locus_tag="BSU_38050" /old_locus_tag="BSU38050" /label="sacP gene" misc_feature complement(3405936..3405945) /Source="Nicolas_upshift_promotors" /id="U2987" /multdbtbs="-" /comp="M21" /sig="SigA" /pcomp="0.258741258741259" /psig="0.536463536463537" /xcortree=1560 /SigmaFactorBS="ctaaaatttgcgtaaatgaaaaaggatcgctgtgtcctttat tcgttggcgaattttaggtctttTTTGTTTAAAtaaaagggggagaaatagatggatt a" /listShort="sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3405950) /Source="Nicolas_upshifts" /id="U2987" /multdbtbs="-" /comp="M21" /sig="SigA" /pcomp="0.258741258741259" /psig="0.536463536463537" /xcortree=1560 /SigmaFactorBS="ctaaaatttgcgtaaatgaaaaaggatcgctgtgtcctttat tcgttggcgaattttaggtctttTTTGTTTAAAtaaaagggggagaaatagatggatt a" /listShort="sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3405952..3406016) /Source="Nicolas_S_feature" /locus_tag="new_3905066_3905130_c" /HighExp="Diami, G150, dia5, Mt0, M9-stat, Lbtran, Gly, dia0, Oxctl, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.743, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1465" promotor_-10 complement(3405995..3406012) /Source="Nicolas_upshift_promotors" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3406016) /Source="Nicolas_upshifts" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3406028..3406035) /Source="Nicolas_upshift_promotors" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3406058..3406077) /Source="Nicolas_upshift_promotors" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3406076) /Source="Nicolas_upshifts" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3406091..3406098) /Source="Nicolas_upshift_promotors" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3406157..3406160 /Source="Nicolas_upshift_promotors" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3406167 /Source="Nicolas_upshifts" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3406175..3406194 /Source="Nicolas_upshift_promotors" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3406219..3406989 /gene="nirC" /locus_tag="BSU_38060" /old_locus_tag="BSU38060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16207915, 16428414, 16850406, 18691156; Product type t : transporter" /codon_start=1 /transl_table=11 /product="nitrite transporter" /protein_id="NP_391685.1" /db_xref="EnsemblGenomes-Gn:BSU38060" /db_xref="EnsemblGenomes-Tr:CAB15832" /db_xref="GOA:P39608" /db_xref="InterPro:IPR000292" /db_xref="InterPro:IPR023271" /db_xref="InterPro:IPR024002" /db_xref="SubtiList:BG10594" /db_xref="UniProtKB/Swiss-Prot:P39608" /translation="METQALQKVEQYALKKQNIFASSKIRYVLRSILASIFIGFGITA ASKTGSYFFMADSPFAFPAAAVTFGAAILMIAYGGGDLFTGNTFYFTYTALRKKISWR DTLYLWMSSYAGNLIGAILFAILISATGLFEEPSVHSFLIHLAEHKMEPPASELFFRG MLCNWLVCLAFFIPMSLKGEGAKLFTMMLFVFCFFISGFEHSIANMCTFAISLLIEHP DTVTLMGAVRNLIPVTLGNLTAGIVMMGWMYYTLNPDQ*" /label="nirC CDS" gene 3406219..3406989 /gene="nirC" /locus_tag="BSU_38060" /old_locus_tag="BSU38060" /label="nirC gene" S_feature 3406990..3408057 /Source="Nicolas_S_feature" /locus_tag="new_3906104_3907171" /HighExp="S0, ferm, M0t45, Lbexp, Mal, dia0, M/G, UNK1, M40t45, BI" /AntisenseName="sacT" /AntisenseCor="-0.34218080984654098" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1466" CDS complement(3407028..3407858) /gene="sacT" /locus_tag="BSU_38070" /old_locus_tag="BSU38070" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1577686, 2163394, 8535520, 8702561, 19202299, 21278164" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1577686, 2163394, 8535520, 8702561, 19202299, 21278164; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator of sacAP expression" /protein_id="NP_391686.1" /db_xref="EnsemblGenomes-Gn:BSU38070" /db_xref="EnsemblGenomes-Tr:CAB15833" /db_xref="GOA:P26212" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="SubtiList:BG10593" /db_xref="UniProtKB/Swiss-Prot:P26212" /translation="MKIYKVLNNNAALIKEDDQEKIVMGPGIAFQKKKNDLIPMNKVE KIFVVRDENEKFKQILQTLPEEHIEIAEDIISYAEGELAAPLSDHIHIALSDHLSFAI ERIQNGLLVQNKLLHEIKALYKKEYEIGLWAIGHVKETLGVSLPEDEAGYIALHIHTA KMDAESMYSALKHTTMIKEMIEKIKQYFNRKVDENSISYQRLVTHLRYAVSRLESNEA LHRMDEEMLYFIQKKYSFAYQCALELAEFLKNEYQLHLPESEAGYITLHVQRLQDLSE *" /label="sacT CDS" gene complement(3407028..3407858) /gene="sacT" /locus_tag="BSU_38070" /old_locus_tag="BSU38070" /label="sacT gene" downshifts complement(3407029) /Source="Nicolas_upshifts" /id="D1967" /incds=0 /nref=49 /ntot=139 /MaxReadThrough="3.34691" /MaxDrop="4.9787" /score="11.2756812" /energy="-8.1" /TU="U2992" /idTUdmin="U2991" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3407884..3407903) /Source="Nicolas_upshift_promotors" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3407890) /Source="Nicolas_upshifts" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3407898..3408200) /gene="ywcI" /locus_tag="BSU_38080" /old_locus_tag="BSU38080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391687.2" /db_xref="EnsemblGenomes-Gn:BSU38080" /db_xref="EnsemblGenomes-Tr:CAB15834" /db_xref="SubtiList:BG10592" /db_xref="UniProtKB/Swiss-Prot:P39607" /translation="MKRLLVSLRVWMVFLMNWVTPDRKTAAAAVYSAQRTYQRKAAVQ AAGLVSFYEWRMAVNEEEKQKAKAAALYKRRCLQAFKESPKQERAGPHLYMAVKRR*" /label="ywcI CDS" gene complement(3407898..3408200) /gene="ywcI" /locus_tag="BSU_38080" /old_locus_tag="BSU38080" /label="ywcI gene" promotor_-35 complement(3407918..3407925) /Source="Nicolas_upshift_promotors" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3408201..3408339) /Source="Nicolas_S_feature" /locus_tag="new_3907315_3907453_c" /HighExp="T5.0H, M9-stat, S2, S4, T4.0H, S3, T3.30H, LoTm, B36, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.823" /TUlongSig="NA" /TUlongPSig="NA" /label="S1467" misc_feature complement(3408324..3408343) /Source="Nicolas_upshift_promotors" /id="U2992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.388611388611389" /psig="0.823176823176823" /xcortree=968 /SigmaFactorBS="cttctaaaaactagttggttttttcactcatattgtgacaaa gaattctctttccaCGGTCTATCATAGAGTCATGagttttgctagagccgctagtttg c" /listShort="S1467, ywcI, sacT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3408339) /Source="Nicolas_upshifts" /id="U2992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.388611388611389" /psig="0.823176823176823" /xcortree=968 /SigmaFactorBS="cttctaaaaactagttggttttttcactcatattgtgacaaa gaattctctttccaCGGTCTATCATAGAGTCATGagttttgctagagccgctagtttg c" /listShort="S1467, ywcI, sacT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3408654..3408662 /Source="Nicolas_upshift_promotors" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3408673..3408691 /Source="Nicolas_upshift_promotors" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3408674 /Source="Nicolas_upshifts" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="upshifts" CDS 3408730..3411150 /gene="vpr" /locus_tag="BSU_38090" /old_locus_tag="BSU38090" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15205417, 15596354, 16946274, 17666034, 18689487, 25666135" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15205417, 15596354, 16946274, 17666034, 18689487, 25666135; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="extracellular serine protease" /protein_id="NP_391688.1" /db_xref="EnsemblGenomes-Gn:BSU38090" /db_xref="EnsemblGenomes-Tr:CAB15835" /db_xref="GOA:P29141" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR003137" /db_xref="InterPro:IPR010259" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR025965" /db_xref="InterPro:IPR034213" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="SubtiList:BG10591" /db_xref="UniProtKB/Swiss-Prot:P29141" /translation="MKKGIIRFLLVSFVLFFALSTGITGVQAAPASSKTSADLEKAEV FGDIDMTTSKKTTVIVELKEKSLAEAKEAGESQSKSKLKTARTKAKNKAIKAVKNGKV NREYEQVFSGFSMKLPANEIPKLLAVKDVKAVYPNVTYKTDNMKDKDVTISEDAVSPQ MDDSAPYIGANDAWDLGYTGKGIKVAIIDTGVEYNHPDLKKNFGQYKGYDFVDNDYDP KETPTGDPRGEATDHGTHVAGTVAANGTIKGVAPDATLLAYRVLGPGGSGTTENVIAG VERAVQDGADVMNLSLGNSLNNPDWATSTALDWAMSEGVVAVTSNGNSGPNGWTVGSP GTSREAISVGATQLPLNEYAVTFGSYSSAKVMGYNKEDDVKALNNKEVELVEAGIGEA KDFEGKDLTGKVAVVKRGSIAFVDKADNAKKAGAIGMVVYNNLSGEIEANVPGMSVPT IKLSLEDGEKLVSALKAGETKTTFKLTVSKALGEQVADFSSRGPVMDTWMIKPDISAP GVNIVSTIPTHDPDHPYGYGSKQGTSMASPHIAGAVAVIKQAKPKWSVEQIKAAIMNT AVTLKDSDGEVYPHNAQGAGSARIMNAIKADSLVSPGSYSYGTFLKENGNETKNETFT IENQSSIRKSYTLEYSFNGSGISTSGTSRVVIPAHQTGKATAKVKVNTKKTKAGTYEG TVIVREGGKTVAKVPTLLIVKEPDYPRVTSVSVSEGSVQGTYQIETYLPAGAEELAFL VYDSNLDFAGQAGIYKNQDKGYQYFDWDGTINGGTKLPAGEYYLLAYAANKGKSSQVL TEEPFTVE*" /label="vpr CDS" gene 3408730..3411150 /gene="vpr" /locus_tag="BSU_38090" /old_locus_tag="BSU38090" /label="vpr gene" upshifts 3408888 /Source="Nicolas_upshifts" /id="U2994" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.677322677322677" /psig="0.986013986013986" /xcortree=625 /SigmaFactorBS="aaaaacgtcggctgatctggaaaaagccgaggtattcggtga tatcgatatgacgacaagcaaaaaaacAACCGTTATAGTGGAATTAAaagaaaaatcc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3408897..3408916 /Source="Nicolas_upshift_promotors" /id="U2994" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.677322677322677" /psig="0.986013986013986" /xcortree=625 /SigmaFactorBS="aaaaacgtcggctgatctggaaaaagccgaggtattcggtga tatcgatatgacgacaagcaaaaaaacAACCGTTATAGTGGAATTAAaagaaaaatcc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts 3411138 /Source="Nicolas_upshifts" /id="D1968" /incds=0 /nref=7 /ntot=104 /MaxReadThrough="0.60305" /MaxDrop="5.33856" /score="26.8487936" /energy="-16.5" /TU="NA" /idTUdmin="U2993" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(3411188..3412189) /gene="ywcH" /locus_tag="BSU_38100" /old_locus_tag="BSU38100" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10913069, 15774866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative monooxygenase" /protein_id="NP_391689.1" /db_xref="EnsemblGenomes-Gn:BSU38100" /db_xref="EnsemblGenomes-Tr:CAB15836" /db_xref="GOA:P39606" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG10590" /db_xref="UniProtKB/Swiss-Prot:P39606" /translation="MVSLSILDQSPVSEGSNAETALQQTVALAQAAEDLGYKRFWVSE HHFSKRLAGSSPEVLISHIAAKTKRIRVGSGGVMLPHYSAYKVAENFRVLEGLTPGRI DLGLGRAPGGMPIASWALNDGGKRNADQYPQQIKELTMYLHDLADDKHRFPNLTAAPH ISTAPDVWLLGSSGESALLAAESGAGYMFAHFINGEGGEGTVRQYKRRFKPSVLGDTP RAAVAVFVLCADTEEKAEELGAVLDFTLLAGEQGIPLEGVPSYEAVRKNTYSPYEQRR IADNRNRMIVGTKEQVKERLLALSNAYETEEIMVVTITHHFEDKLRSYRLLQEAFAD* " /label="ywcH CDS" gene complement(3411188..3412189) /gene="ywcH" /locus_tag="BSU_38100" /old_locus_tag="BSU38100" /label="ywcH gene" S_feature complement(3412190..3412351) /Source="Nicolas_S_feature" /locus_tag="new_3911304_3911465_c" /HighExp="Etha, Diami, dia15, LPhT, dia5, H2O2, B60, LBGstat, M9-stat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S1468" CDS complement(3412363..3413112) /gene="nfrAA" /locus_tag="BSU_38110" /old_locus_tag="BSU38110" /EC_number="1.5.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9535080, 9836433, 10913069, 15774866, 20727352, 20862523, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9535080, 9836433, 10913069, 15774866, 20727352, 20862523, 24847778, 25288929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMN-containing NADPH-linked nitro/flavin reductase" /protein_id="NP_391690.1" /db_xref="EnsemblGenomes-Gn:BSU38110" /db_xref="EnsemblGenomes-Tr:CAB15837" /db_xref="GOA:P39605" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR016446" /db_xref="InterPro:IPR029479" /db_xref="PDB:3N2S" /db_xref="SubtiList:BG10589" /db_xref="UniProtKB/Swiss-Prot:P39605" /translation="MNNTIETILNHRSIRSFTDQLLTAEEIDTLVKSAQAASTSSYVQ AYSIIGVSDPEKKRELSVLAGNQPYVEKNGHFFVFCADLYRHQQLAEEKGEHISELLE NTEMFMVSLIDAALAAQNMSIAAESMGLGICYIGGIRNELDKVTEVLQTPDHVLPLFG LAVGHPANLSGKKPRLPKQAVYHENTYNVNTDDFRHTMNTYDKTISDYYRERTNGKRE ETWSDQILNFMKQKPRTYLNDYVKEKGFNKN*" /label="nfrAA CDS" gene complement(3412363..3413112) /gene="nfrAA" /locus_tag="BSU_38110" /old_locus_tag="BSU38110" /label="nfrAA gene" downshifts complement(3412396) /Source="Nicolas_upshifts" /id="D1969" /incds=0 /nref=11 /ntot=191 /MaxReadThrough="5.92216" /MaxDrop="3.39651" /score="17.7447455" /energy="-9.9" /TU="U2995" /idTUdmin="U2996" /TUdmin=770 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3413130..3413149) /Source="Nicolas_upshift_promotors" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3413147) /Source="Nicolas_upshifts" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3413164..3413167) /Source="Nicolas_upshift_promotors" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3413218..3414399) /gene="rodA" /locus_tag="BSU_38120" /old_locus_tag="BSU38120" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9622350, 15612918, 15849754, 16850406, 28085152" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 15612918, 15849754, 16850406, 28085152; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycosyltransferase involved in extension of thelateral walls of the cell" /protein_id="NP_391691.1" /db_xref="EnsemblGenomes-Gn:BSU38120" /db_xref="EnsemblGenomes-Tr:CAB15838" /db_xref="GOA:P39604" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG10588" /db_xref="UniProtKB/Swiss-Prot:P39604" /translation="MSRYKKQQSPFYQGDLIFIFGVFFIISVVSIYAAGQFGQYGNTD WIQQIVFYLLGAVAITVLLYFDLEQLEKLSLYIFIIGILSLIILKISPESIAPVIKGA KSWFRIGRITIQPSEFMKVGLIMMLASVIGKANPKGVRTLRDDIHLLLKIAGVAVIPV GLILMQDAGTAGICMFIVLVMVFMSGINWKLIAIIAGSGILLISLILLVMINFPDVAK SVGIQDYQIKRVTSWVSASNETQEDSNDSWQVDQAIMAIGSGGILGNGISNLKVYVPE STTDFIFSIIGESFGFIGCAIVVIMFFFLIYRLVVLIDKIHPFNRFASFFCVGYTALI VIHTFQNIGMNIGIMPVTGIPLLFVSYGGSSTLSTLIGFGIVYNASVQLTKYRSYLFN S*" /label="rodA CDS" gene complement(3413218..3414399) /gene="rodA" /locus_tag="BSU_38120" /old_locus_tag="BSU38120" /label="rodA gene" downshifts complement(3413232) /Source="Nicolas_upshifts" /id="D1970" /incds=0 /nref=20 /ntot=124 /MaxReadThrough="3.38052" /MaxDrop="5.67563" /score="31.4805549" /energy="-13.3" /TU="U2996" /idTUdmin="U2996" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(3414400..3414531) /Source="Nicolas_S_feature" /locus_tag="new_3913514_3913645_c" /HighExp="Heat, T0.30H, H2O2, T1.0H, Salt, Paraq, T1.30H, LBGstat, Oxctl, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1469" promotor_-10 complement(3414525..3414540) /Source="Nicolas_upshift_promotors" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="promotor_-10" upshifts complement(3414531) /Source="Nicolas_upshifts" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="upshifts" promotor_-35 complement(3414552..3414561) /Source="Nicolas_upshift_promotors" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="promotor_-35" promotor_-35 3414766..3414773 /Source="Nicolas_upshift_promotors" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3414784..3414894 /Source="Nicolas_S_feature" /locus_tag="new_3913898_3914008" /HighExp="M9-stat, T0.30H, T1.30H, T1.0H, T4.0H, T2.30H, T3.30H, T3.0H, T5.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1470" promotor_-10 3414784..3414803 /Source="Nicolas_upshift_promotors" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3414784 /Source="Nicolas_upshifts" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="upshifts" CDS 3414895..3415158 /gene="ywcE" /locus_tag="BSU_38130" /old_locus_tag="BSU38130" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16159778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16159778; Product type f: factor" /codon_start=1 /transl_table=11 /product="holin-like protein required for proper spore morphogenesis and germination" /protein_id="NP_391692.1" /db_xref="EnsemblGenomes-Gn:BSU38130" /db_xref="EnsemblGenomes-Tr:CAB15839" /db_xref="GOA:P39603" /db_xref="InterPro:IPR020185" /db_xref="SubtiList:BG10587" /db_xref="UniProtKB/Swiss-Prot:P39603" /translation="MMDMFFAYLLVASATPLFIWLDNKKVALSAIPPIILMWVFFFFY ATESLSPLGHTLMIILFAVNVIVAHIAAFIIYGLPYLRRKRSS*" /label="ywcE CDS" gene 3414895..3415158 /gene="ywcE" /locus_tag="BSU_38130" /old_locus_tag="BSU38130" /label="ywcE gene" downshifts 3415048 /Source="Nicolas_upshifts" /id="D1971" /incds=1 /nref=1 /ntot=99 /MaxReadThrough="6.85004" /MaxDrop="2.5697" /score="27.9247684" /energy="-11.4" /TU="U2997" /idTUdmin="U2997" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 3415164 /Source="Nicolas_upshifts" /id="D1972" /incds=0 /nref=7 /ntot=90 /MaxReadThrough="2.04756" /MaxDrop="6.52141" /score="27.9247684" /energy="-11.4" /TU="NA" /idTUdmin="U2997" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(3415201..3415575) /gene="qoxD" /locus_tag="BSU_38140" /old_locus_tag="BSU38140" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit IV)" /protein_id="NP_391693.1" /db_xref="EnsemblGenomes-Gn:BSU38140" /db_xref="EnsemblGenomes-Tr:CAB15840" /db_xref="GOA:P34959" /db_xref="InterPro:IPR005171" /db_xref="InterPro:IPR014250" /db_xref="SubtiList:BG10586" /db_xref="UniProtKB/Swiss-Prot:P34959" /translation="MANKSAEHSHFPWKHIVGFILSIVLTLLALWVAVYTDLSSSAKL WIIFGFAFIQAALQLLMFMHMTESENGTIQVGNTLFGFFGAIVIVLGSIWIFAAHYHH GDHMDGNPPGGAEHSEHSGHNE*" /label="qoxD CDS" gene complement(3415201..3415575) /gene="qoxD" /locus_tag="BSU_38140" /old_locus_tag="BSU38140" /label="qoxD gene" downshifts complement(3415212) /Source="Nicolas_upshifts" /id="D1973" /incds=0 /nref=222 /ntot=267 /MaxReadThrough="2.42368" /MaxDrop="9.0593" /score="21.3154492" /energy="-11.4" /TU="NA" /idTUdmin="U3000" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3415577..3416191) /gene="qoxC" /locus_tag="BSU_38150" /old_locus_tag="BSU38150" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit III)" /protein_id="NP_391694.1" /db_xref="EnsemblGenomes-Gn:BSU38150" /db_xref="EnsemblGenomes-Tr:CAB15841" /db_xref="GOA:P34958" /db_xref="InterPro:IPR000298" /db_xref="InterPro:IPR013833" /db_xref="InterPro:IPR014246" /db_xref="InterPro:IPR024791" /db_xref="InterPro:IPR033946" /db_xref="InterPro:IPR035973" /db_xref="SubtiList:BG10585" /db_xref="UniProtKB/Swiss-Prot:P34958" /translation="MEHAEHGNSNAPMEYQSETGRLNILGFWIFLGAEIVLFSTLFAT FFVLKNRTAGGVLPDELFEVNLVMIMTFLLLISSFTCGIAVHEMRRGSLKGVVIWTII TLLLGAGFVGCEINEFVHYVHEGAALSTSAFWSGFFVLLGTHGTHVTIGIFWITGILI QLKKRGLTPQTSSKIFISSLYWHFLDVVWIFIFTGVYLMGLGGL*" /label="qoxC CDS" gene complement(3415577..3416191) /gene="qoxC" /locus_tag="BSU_38150" /old_locus_tag="BSU38150" /label="qoxC gene" CDS complement(3416205..3418154) /gene="qoxB" /locus_tag="BSU_38160" /old_locus_tag="BSU38160" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 22720735, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 22720735, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit I)" /protein_id="NP_391695.1" /db_xref="EnsemblGenomes-Gn:BSU38160" /db_xref="EnsemblGenomes-Tr:CAB15842" /db_xref="GOA:P34956" /db_xref="InterPro:IPR000883" /db_xref="InterPro:IPR014233" /db_xref="InterPro:IPR023615" /db_xref="InterPro:IPR023616" /db_xref="InterPro:IPR036927" /db_xref="SubtiList:BG10584" /db_xref="UniProtKB/Swiss-Prot:P34956" /translation="MKFKWDEFFVTGDPLILGAQVSIALSTIAIIFVLTYFKKWKWLW SEWITTVDHKKLGIMYIISAVIMLFRGGVDGLMMRAQLALPNNSFLDSNHYNEIFTTH GTIMIIFMAMPFLIGLINVVVPLQIGARDVAFPYLNNLSFWTFFVGAMLFNISFVIGG SPNAGWTSYMPLASNDMSPGPGENYYLLGLQIAGIGTLMTGINFMVTILKMRTKGMTL MRMPMFTWTTLITMVIIVFAFPVLTVALALLSFDRLFGAHFFTLEAGGMPMLWANLFW IWGHPEVYIVILPAFGIFSEIISSFARKQLFGYKAMVGSIIAISVLSFLVWTHHFFTM GNSASVNSFFSITTMAISIPTGVKIFNWLFTMYKGRISFTTPMLWALAFIPNFVIGGV TGVMLAMAAADYQYHNTYFLVSHFHYVLIAGTVFACFAGFIFWYPKMFGHKLNERIGK WFFWIFMIGFNICFFPQYFLGLQGMPRRIYTYGPNDGWTTLNFISTVGAFMMGVGFLI LCYNIYYSFRYSTREISGDSWGVGRTLDWATSSAIPPHYNFAVLPEVKSQDAFLHMKE EKTELYPESKFKKIHMPSNSGRPFFMSVAFGLAGFGLVFEWYWMGVVGLIGVLLCMVL RSFEYDNGYYISVDEIKETERKISE*" /label="qoxB CDS" gene complement(3416205..3418154) /gene="qoxB" /locus_tag="BSU_38160" /old_locus_tag="BSU38160" /label="qoxB gene" misc_feature 3417418..3417437 /Source="Nicolas_upshift_promotors" /id="U2998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.869130869130869" /psig="0.894105894105894" /xcortree=62 /SigmaFactorBS="gcttccaatgtgaaaaagtgagcgccgaacaaacgatcaaat gataaaagtgctAATGCTACTGTAAGTACAGGgaacgcaaacacgataataaccattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3417424 /Source="Nicolas_upshifts" /id="U2998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.869130869130869" /psig="0.894105894105894" /xcortree=62 /SigmaFactorBS="gcttccaatgtgaaaaagtgagcgccgaacaaacgatcaaat gataaaagtgctAATGCTACTGTAAGTACAGGgaacgcaaacacgataataaccattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box 3417848..3417948 /Source="Nicolas_upshift_promotors" /id="U2999" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.002997002997003" /xcortree=78 /SigmaFactorBS="cgtgagttgtaaaaatttcattatagtggtttgagtctaaaa aactgttattcggaagcgctagctgggcacgcatcatcagaccgtcgacaccgccacg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3417908 /Source="Nicolas_upshifts" /id="U2999" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.002997002997003" /xcortree=78 /SigmaFactorBS="cgtgagttgtaaaaatttcattatagtggtttgagtctaaaa aactgttattcggaagcgctagctgggcacgcatcatcagaccgtcgacaccgccacg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3418018 /Source="Nicolas_upshifts" /id="D1974" /incds=1 /nref=1 /ntot=73 /MaxReadThrough="3.07388" /MaxDrop="3.44223" /score="-7.14620582" /energy="-8.1" /TU="U2999" /idTUdmin="U2999" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" CDS complement(3418182..3419147) /gene="qoxA" /locus_tag="BSU_38170" /old_locus_tag="BSU38170" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 22720735, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 22720735, 26196462; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit II)" /protein_id="NP_391696.2" /db_xref="EnsemblGenomes-Gn:BSU38170" /db_xref="EnsemblGenomes-Tr:CAB15843" /db_xref="GOA:P34957" /db_xref="InterPro:IPR002429" /db_xref="InterPro:IPR006332" /db_xref="InterPro:IPR006333" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR011759" /db_xref="InterPro:IPR034227" /db_xref="InterPro:IPR036257" /db_xref="SubtiList:BG10583" /db_xref="UniProtKB/Swiss-Prot:P34957" /translation="MIFLFRALKPLLVLALLTVVFVLGGCSNASVLDPKGPVAEQQSD LILLSIGFMLFIVGVVFVLFTIILVKYRDRKGKDNGSYNPEIHGNTFLEVVWTVIPIL IVIALSVPTVQTIYSLEKAPEATKDKEPLVVYATSVDWKWVFSYPEQDIETVNYLNIP VDRPILFKISSADSMASLWIPQLGGQKYAMAGMLMDQYLQADKVGTYEGRNANFTGEH FADQEFDVNAVTEKDFNSWVKKTQNEAPKLTKEKYDELMLPENVDELTFSSTHLKYVD HGQDAEYAMEARKRLGYQAVSPHSKTDPFENVKKNEFKKSDDTEE*" /label="qoxA CDS" gene complement(3418182..3419147) /gene="qoxA" /locus_tag="BSU_38170" /old_locus_tag="BSU38170" /label="qoxA gene" S_feature complement(3419148..3419216) /Source="Nicolas_S_feature" /locus_tag="new_3918262_3918330_c" /HighExp="M0t90, M40t90, Lbtran, Lbstat, M40t45, S2, nit, ferm, LBGstat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigEF" /TUshortPSig="0.626, 1, 1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1471" promotor_-10 complement(3419203..3419222) /Source="Nicolas_upshift_promotors" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3419216) /Source="Nicolas_upshifts" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3419218..3419403) /Source="Nicolas_S_feature" /locus_tag="new_3918332_3918517_c" /HighExp="LBGstat, Heat, G150, G135, LBGtran, G180, BMM, Salt, LBGexp, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="1, 1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1472" promotor_-35 complement(3419235..3419239) /Source="Nicolas_upshift_promotors" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3419334..3419339 /Source="Nicolas_upshift_promotors" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3419355..3419373 /Source="Nicolas_upshift_promotors" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3419360 /Source="Nicolas_upshifts" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3419394..3419413) /Source="Nicolas_upshift_promotors" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3419403) /Source="Nicolas_upshifts" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3419405..3419514) /Source="Nicolas_S_feature" /locus_tag="new_3918519_3918628_c" /HighExp="Heat, Salt, LBGstat, BMM, Oxctl, H2O2, MG 15, UNK1, MG-0.1, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1473" promotor_-35 complement(3419428..3419432) /Source="Nicolas_upshift_promotors" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3419470 /Source="Nicolas_upshifts" /id="D1975" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="2.69533" /MaxDrop="4.01393" /score="13.5410442" /energy="-16.4" /TU="U3001" /idTUdmin="U3001" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3419499..3419518) /Source="Nicolas_upshift_promotors" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3419514) /Source="Nicolas_upshifts" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3419534..3419538) /Source="Nicolas_upshift_promotors" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3419592..3419610) /Source="Nicolas_upshift_promotors" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3419597..3419603 /Source="Nicolas_upshift_promotors" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3419609) /Source="Nicolas_upshifts" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3419618..3419636 /Source="Nicolas_upshift_promotors" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3419621 /Source="Nicolas_upshifts" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3419626..3419631) /Source="Nicolas_upshift_promotors" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3419663..3419908 /gene="ywzA" /locus_tag="BSU_38180" /old_locus_tag="BSU38180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391697.2" /db_xref="EnsemblGenomes-Gn:BSU38180" /db_xref="EnsemblGenomes-Tr:CAB15844" /db_xref="GOA:O32282" /db_xref="InterPro:IPR007341" /db_xref="SubtiList:BG14162" /db_xref="UniProtKB/Swiss-Prot:O32282" /translation="MSFLISLIVAIIIGWLGSLFVKGDMPGGIIGSMIAGLIGAWIGH GLLGTWGPHLAGFAIIPAVIGAAIVVFLVSLLTRKRG*" /label="ywzA CDS" gene 3419663..3419908 /gene="ywzA" /locus_tag="BSU_38180" /old_locus_tag="BSU38180" /label="ywzA gene" downshifts 3419890 /Source="Nicolas_upshifts" /id="D1976" /incds=0 /nref=125 /ntot=189 /MaxReadThrough="2.63086" /MaxDrop="7.72876" /score="13.5410442" /energy="-16.4" /TU="NA" /idTUdmin="U3005" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(3419979..3421520) /gene="galT" /locus_tag="BSU_38190" /old_locus_tag="BSU38190" /EC_number="2.7.7.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9555917, 11790749" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9555917, 11790749; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galactose-1-phosphate uridyltransferase" /protein_id="NP_391698.2" /db_xref="EnsemblGenomes-Gn:BSU38190" /db_xref="EnsemblGenomes-Tr:CAB15845" /db_xref="GOA:P39575" /db_xref="InterPro:IPR000766" /db_xref="InterPro:IPR005849" /db_xref="InterPro:IPR005850" /db_xref="InterPro:IPR023425" /db_xref="SubtiList:BG10582" /db_xref="UniProtKB/Swiss-Prot:P39575" /translation="MSIIEHLEQLLEYGLERKLISIWDREYTRNRLYEALGITHPEPN SSTSIKQSQSLPDLLAPIYKWAAETGRMEADTDTYRDLLSAKLMGCFVPAPSEVIRKF EETKALYGPKQATKEFYQYSEDVYYIRTDRIAKNVHWTVPTEYGELEMTINLSKPEKD PKAIAAAKEQEQTNYPMCLLCKENVGFEGSVNHPARQNHRIIPVILEDEQWFLQFSPY VYYPEHCIVLKGEHEPMEISKKTFERLLSFLGQYPHYFIGSNADLPIVGGSILSHDHF QGGAHDFPMARAEAEDVYELNDYPGVSLGLVKWPMSVLRLQGDEPGHVAEAADHIFRT WQTYSDEKAGIAAYTGDTPHNTVTPIARRRGDLYELDIVLRNNRTDEEHPLGIFHPHQ EVHHIKKENIGLIEVMGLAILPGRLQEEMKETAAALCSADPKTALEQNPLTAKHSEWA LRTMEKRTITKENVDLVIKEELGHVFARILEHAGVFKQTAEGKQAFRRFIDQLGAKPV KSLNR*" /label="galT CDS" gene complement(3419979..3421520) /gene="galT" /locus_tag="BSU_38190" /old_locus_tag="BSU38190" /label="galT gene" downshifts complement(3420008) /Source="Nicolas_upshifts" /id="D1977" /incds=0 /nref=190 /ntot=254 /MaxReadThrough="0.3431" /MaxDrop="6.63153" /score="21.0691542" /energy="-14.7" /TU="NA" /idTUdmin="U3006" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3421524..3422696) /gene="galK" /locus_tag="BSU_38200" /old_locus_tag="BSU38200" /EC_number="2.7.1.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9555917" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9555917; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galactokinase" /protein_id="NP_391699.1" /db_xref="EnsemblGenomes-Gn:BSU38200" /db_xref="EnsemblGenomes-Tr:CAB15846" /db_xref="GOA:P39574" /db_xref="InterPro:IPR000705" /db_xref="InterPro:IPR006203" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR006206" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR019539" /db_xref="InterPro:IPR019741" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR022963" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10581" /db_xref="UniProtKB/Swiss-Prot:P39574" /translation="MREELKGIFASVFGEKEGLRFFFAPGRVNLIGEHTDYNGGHVFP CALTMGTYAAVAERNDGLVRMYSDNFRNAGIKECSLDDIRYQKEDDWANYPKGVIYEF QQRGYAVPHGFDIVFSGNIPNGAGLSSSASIELLMGVVLQSYFHPEVDALELVKMAQH AENHFIGVNCGIMDQFAIGMGKKHHAMLLNCDTLDYEYSKLNVSGLALVIANTNKKRT LADSSYNTRRQECNDALLDLKKGLDIAALGDIKPSDFDAHSSLIQNETNRRRAKHAVY ENHRAIKTAHMFKENNIDEIGQLMKESHLSLKDDYEVTCPELDELVFAAWDHEGVIGS RMTGAGFGGCTISIVKDEFVDDFIQKVGDRYQEKTGLRADFYVADIGEGARELKGE*" /label="galK CDS" gene complement(3421524..3422696) /gene="galK" /locus_tag="BSU_38200" /old_locus_tag="BSU38200" /label="galK gene" promotor_-10 complement(3422714..3422732) /Source="Nicolas_upshift_promotors" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3422736) /Source="Nicolas_upshifts" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3422747..3422753) /Source="Nicolas_upshift_promotors" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3422777..3423160) /gene="ywcD" /locus_tag="BSU_38210" /old_locus_tag="BSU38210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9882654, 15849754, 16850406, 18192405; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative cell wall glycosylation protein" /protein_id="NP_391700.1" /db_xref="EnsemblGenomes-Gn:BSU38210" /db_xref="EnsemblGenomes-Tr:CAB15847" /db_xref="GOA:P39602" /db_xref="InterPro:IPR007267" /db_xref="SubtiList:BG10580" /db_xref="UniProtKB/Swiss-Prot:P39602" /translation="MYIIMGVFTTIVNIASFYILVEIMNVDYKAATVAAWILSVLFAY ITNKLYVFQQKTHDLQSLLKELTAFFSVRVLSLGIDLGMMIILVGQFNTNETLAKILD NAVIVVVNYVASKWLVFKKTKEEGV*" /label="ywcD CDS" gene complement(3422777..3423160) /gene="ywcD" /locus_tag="BSU_38210" /old_locus_tag="BSU38210" /label="ywcD gene" CDS complement(3423178..3423849) /gene="slrC" /locus_tag="BSU_38220" /old_locus_tag="BSU38220" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18647168" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18647168; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of slrA (biofilm formation)" /protein_id="NP_391701.2" /db_xref="EnsemblGenomes-Gn:BSU38220" /db_xref="EnsemblGenomes-Tr:CAB15848" /db_xref="GOA:P39601" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG10579" /db_xref="UniProtKB/Swiss-Prot:P39601" /translation="MKKNKFQIKREATFESFIDAGVNLLIDRAYDPVSVEDISRAAGY SKGAFYVHFVSKDDFLLYLLEKRQMKKKIIIGYLDQMERESVKSLTLDEAAKHAAELL YSYYINKPSWDITSFAMNMPTYKVLKKCKAYVRLYELWVEENVLYIKWLKERKLIDAC IDPEYTAKIICAVLDGIIKQSYVLGQPATFRSFLDALSVFFTLDREHERPRILKSFSE SEEHQ*" /label="slrC CDS" gene complement(3423178..3423849) /gene="slrC" /locus_tag="BSU_38220" /old_locus_tag="BSU38220" /label="slrC gene" promotor_-10 complement(3423871..3423890) /Source="Nicolas_upshift_promotors" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3423880) /Source="Nicolas_upshifts" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3423906..3423909) /Source="Nicolas_upshift_promotors" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3423990..3423993 /Source="Nicolas_upshift_promotors" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3424008..3424027 /Source="Nicolas_upshift_promotors" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3424017..3424204 /Source="Nicolas_S_feature" /locus_tag="new_3923131_3923318" /HighExp="T0.30H, T1.0H, Cold, T1.30H, HiOs, T-0.40H, T2.0H, T2.30H, T4.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1474" upshifts 3424017 /Source="Nicolas_upshifts" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="upshifts" CDS 3424205..3424363 /gene="slrA" /locus_tag="BSU_38229" /old_locus_tag="BSU38229" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18647168, 26857544" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18647168, 26857544; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-repressor of SlrR" /protein_id="YP_003097794.1" /db_xref="EnsemblGenomes-Gn:BSU38229" /db_xref="EnsemblGenomes-Tr:CAX52707" /db_xref="GOA:P0C8M5" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR036281" /db_xref="UniProtKB/Swiss-Prot:P0C8M5" /translation="MKTHVKKDLDKGWHMLIQEARSIGLGIHDVRQFLESETASRKKN HKKTVRQD*" /label="slrA CDS" gene 3424205..3424363 /gene="slrA" /locus_tag="BSU_38229" /old_locus_tag="BSU38229" /label="slrA gene" S_feature 3424364..3424748 /Source="Nicolas_S_feature" /locus_tag="new_3923478_3923862" /HighExp="T0.30H, Cold, T1.30H, T2.0H, T1.0H, HiOs, T2.30H, T3.0H, LBGstat, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1475" promotor_-35 3424729..3424734 /Source="Nicolas_upshift_promotors" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3424750..3424768 /Source="Nicolas_upshift_promotors" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3424750 /Source="Nicolas_upshifts" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="upshifts" CDS 3424806..3425114 /gene="vbfB" /locus_tag="BSU_38230" /old_locus_tag="BSU38230" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:26060272, 28357266" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26060272, 28357266; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of acetate transporter as a volatile signal for biofilm formation" /protein_id="NP_391702.1" /db_xref="EnsemblGenomes-Gn:BSU38230" /db_xref="EnsemblGenomes-Tr:CAB15849" /db_xref="GOA:P39600" /db_xref="InterPro:IPR007436" /db_xref="SubtiList:BG10578" /db_xref="UniProtKB/Swiss-Prot:P39600" /translation="MYKADYKQIAATPSFQAFLKQKRAFIVPSAIFFFVFYFSLPVLT SYFTFLNAPAIGAVSWAWLFAIAQFAMTWILSTVYSRRAAHFDKYVSALKEDLKGEQT *" /label="vbfB CDS" gene 3424806..3425114 /gene="vbfB" /locus_tag="BSU_38230" /old_locus_tag="BSU38230" /label="vbfB gene" downshifts complement(3424892) /Source="Nicolas_upshifts" /id="D1978" /incds=1 /nref=3 /ntot=15 /MaxReadThrough="0.42282" /MaxDrop="5.4957" /score="10.1452497" /energy="-8.3" /TU="NA" /idTUdmin="U3010" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(3424896..3424996) /Source="Nicolas_upshift_promotors" /id="U3010" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.731268731268731" /psig="0.017982017982018" /xcortree=279 /SigmaFactorBS="aacagccaagcccatgaaacagctccaatggccggtgcattc aaaaaggtgaaataagatgtcaaaacagggagtgaaaaataaaaaacaaaaaagaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3424936) /Source="Nicolas_upshifts" /id="U3010" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.731268731268731" /psig="0.017982017982018" /xcortree=279 /SigmaFactorBS="aacagccaagcccatgaaacagctccaatggccggtgcattc aaaaaggtgaaataagatgtcaaaacagggagtgaaaaataaaaaacaaaaaagaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 3425111..3426652 /gene="vbfA" /locus_tag="BSU_38240" /old_locus_tag="BSU38240" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 26060272, 28357266" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 26060272, 28357266; Product type t: transporter" /codon_start=1 /transl_table=11 /product="acetate Na+-dependent symporter subunit involvedin volatile signal for biofilm formation" /protein_id="NP_391703.2" /db_xref="EnsemblGenomes-Gn:BSU38240" /db_xref="EnsemblGenomes-Tr:CAB15850" /db_xref="GOA:P39599" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG10577" /db_xref="UniProtKB/Swiss-Prot:P39599" /translation="MNMTAFLLFLAIVGLTLIITYFAAKRTKTTSEFYTAGGGLTGVQ NGLAIAGDYMSAASFLGIAGMIALYGFDGFFYSIGFLVAYLVVLYIVAEPLRNLGKYT MADMIAARFKEKKIRGVAALNTIAISTFYMIAQLVGAGALIKLLLGLDYTAAVLIVGV LMTIYVVFGGMIATSWVQIIKAVLLMAGTLVISIIVFSKFGFSLNTMFEQMKTATPLG ADFLNPGNKYKVPLETLSLNLALVLGTAGLPHILIRFYTVKDAKTARTSVVSATWIIG VFYIMTVFLGFGAAAFVGFDAITAADQAGNMAAPLLAKALGGDFLFAFVSAIAFATIL AVVTGLVLSAASAFAHDIYSQIIRKGEATEKEQMKAARWASVAVSVLSILLAIFAQSL NVAFLVALAFAVAASANLPLIVFTVFWKRFNASGALWGSLTGLISALVLVSMSPSVWD PAGGAIFTGDPLIPLSNPGIISIPLGFLGAWLGTVLSSDKTIDEDTFAEIQVKAHTGV HMEQE*" /label="vbfA CDS" gene 3425111..3426652 /gene="vbfA" /locus_tag="BSU_38240" /old_locus_tag="BSU38240" /label="vbfA gene" downshifts 3426643 /Source="Nicolas_upshifts" /id="D1979" /incds=0 /nref=4 /ntot=35 /MaxReadThrough="2.40129" /MaxDrop="4.15104" /score="2.66606932" /energy="-7.8" /TU="NA" /idTUdmin="U3009" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3426683..3427285) /gene="ywbO" /locus_tag="BSU_38250" /old_locus_tag="BSU38250" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur oxido-reductase" /protein_id="NP_391704.1" /db_xref="EnsemblGenomes-Gn:BSU38250" /db_xref="EnsemblGenomes-Tr:CAB15851" /db_xref="GOA:P39598" /db_xref="InterPro:IPR001853" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10576" /db_xref="UniProtKB/Swiss-Prot:P39598" /translation="MTVHIKVYSDYVCPFCFVGKAAFEEAIKGKDVEVEWMPFELRPS PSPQLDPVNDPSKQYMWQTSIQPMAEKLGVEINFPNVSPHPYTDLAFEGFHFAKEYNK GHEYNTRVFQAFFQEDQNIGDIDILTKLAEEVGLDGASFKSALETRTYQDVQRQALKH AYEEADITAVPTFIIGDTVIPGAAGKDVFEKAISDEQKKK*" /label="ywbO CDS" gene complement(3426683..3427285) /gene="ywbO" /locus_tag="BSU_38250" /old_locus_tag="BSU38250" /label="ywbO gene" downshifts complement(3426697) /Source="Nicolas_upshifts" /id="D1980" /incds=0 /nref=12 /ntot=123 /MaxReadThrough="1.89374" /MaxDrop="3.51247" /score="21.9354981" /energy="-7.8" /TU="NA" /idTUdmin="U3011" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3427286..3427567) /Source="Nicolas_S_feature" /locus_tag="new_3926400_3926681_c" /HighExp="T1.0H, G135, G150, T1.30H, Lbexp, G180, Lbstat, dia5, LBGexp, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.984, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1476" CDS complement(3427568..3428818) /gene="efeB" /locus_tag="BSU_38260" /old_locus_tag="BSU38260" /EC_number="1.11.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15554971, 16672620, 16987175, 18931290, 19383693, 21479178, 23764491, 24620988, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15554971, 16672620, 16987175, 18931290, 19383693, 21479178, 23764491, 24620988, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxidase converting ferric iron into ferrous iron" /protein_id="NP_391705.1" /db_xref="EnsemblGenomes-Gn:BSU38260" /db_xref="EnsemblGenomes-Tr:CAB15852" /db_xref="GOA:P39597" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR006313" /db_xref="InterPro:IPR006314" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019546" /db_xref="SubtiList:BG10575" /db_xref="UniProtKB/Swiss-Prot:P39597" /translation="MSDEQKKPEQIHRRDILKWGAMAGAAVAIGASGLGGLAPLVQTA AKPSKKDEKEEEQIVPFYGKHQAGITTAHQTYVYFAALDVTAKDKSDIITLFRNWTSL TQMLTSGKKMSAEQRNQYLPPQDTGESADLSPSNLTVTFGFGPGFFEKDGKDRFGLKS KKPKHLAALPAMPNDNLDEKQGGGDICIQVCADDEQVAFHALRNLLNQAVGTCEVRFV NKGFLSGGKNGETPRNLFGFKDGTGNQSTKDDTLMNSIVWIQSGEPDWMTGGTYMAFR KIKMFLEVWDRSSLKDQEDTFGRRKSSGAPFGQKKETDPVKLNQIPSNSHVSLAKSTG KQILRRAFSYTEGLDPKTGYMDAGLLFISFQKNPDNQFIPMLKALSAKDALNEYTQTI GSALYACPGGCKKGEYIAQRLLES*" /label="efeB CDS" gene complement(3427568..3428818) /gene="efeB" /locus_tag="BSU_38260" /old_locus_tag="BSU38260" /label="efeB gene" downshifts complement(3427664) /Source="Nicolas_upshifts" /id="D1981" /incds=1 /nref=67 /ntot=232 /MaxReadThrough="5.0552" /MaxDrop="3.65898" /score="21.9354981" /energy="-7.8" /TU="U3011,U3012" /idTUdmin="U3011" /TUdmin="-967" /isTUend="FALSE" /label="downshifts" CDS complement(3428837..3429994) /gene="efeM" /locus_tag="BSU_38270" /old_locus_tag="BSU38270" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipoprotein binding ferrous or ferric iron for transport" /protein_id="NP_391706.1" /db_xref="EnsemblGenomes-Gn:BSU38270" /db_xref="EnsemblGenomes-Tr:CAB15853" /db_xref="GOA:P39596" /db_xref="InterPro:IPR018976" /db_xref="InterPro:IPR034981" /db_xref="SubtiList:BG10574" /db_xref="UniProtKB/Swiss-Prot:P39596" /translation="MNFTKIAVSAGCILALCAGCGANDTSSTKEKASSEKSGVTKEIT ASVNKMETIISKLNDSVEKGDQKEIEKKGKELNSYWLSFENDIRSDYPFEYTEIEKHL QPIYTEAQKDKPDAGKIKTESESLKASLEDLTEAKKSGKKASDQLAKAADEYKGYVKE QSDQLVKATEAFTGAVKSGDIEKSKTLYAKARVYYERIEPIAESLGDLDPKIDAREND VEEGDKWTGFHKLEKAIWKDQDISGEKATADQLLKDVKELDGSIQSLKLTPEQIVAGA MELLNEAGISKITGEEERYSRIDLVDLMANVEGSEAVYQTVKSALVKDHSDLTEKLDT EFSEFEVLMAKYKTNDQSYTSYDKLSEKQIRELSTKLTTLSETMSKIANVL*" /label="efeM CDS" gene complement(3428837..3429994) /gene="efeM" /locus_tag="BSU_38270" /old_locus_tag="BSU38270" /label="efeM gene" misc_feature complement(3428910..3428929) /Source="Nicolas_upshift_promotors" /id="U3011" /multdbtbs="SigW,SigX" /comp="M4" /sig="SigA" /pcomp="0.917082917082917" /psig="0.984015984015984" /xcortree=3235 /SigmaFactorBS="atacggagttcagcgaatttgaagttttaatggcaaaataca aaacaaatgatcagtcctatacgtctTATGATAAATTAAGTGAAAAgcaaatcagaga g" /listShort="efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3428937) /Source="Nicolas_upshifts" /id="U3011" /multdbtbs="SigW,SigX" /comp="M4" /sig="SigA" /pcomp="0.917082917082917" /psig="0.984015984015984" /xcortree=3235 /SigmaFactorBS="atacggagttcagcgaatttgaagttttaatggcaaaataca aaacaaatgatcagtcctatacgtctTATGATAAATTAAGTGAAAAgcaaatcagaga g" /listShort="efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3429991..3431436) /gene="efeU" /locus_tag="BSU_38280" /old_locus_tag="BSU38280" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrous ion permease" /protein_id="NP_391707.2" /db_xref="EnsemblGenomes-Gn:BSU38280" /db_xref="EnsemblGenomes-Tr:CAB15854" /db_xref="GOA:P39595" /db_xref="InterPro:IPR004923" /db_xref="SubtiList:BG10573" /db_xref="UniProtKB/Swiss-Prot:P39595" /translation="MARGLALILFSLLMVFGSAAHAEDDPIAALIQLNKQMIKSVKDG DMDSAQQTFDTFKAKWKKEEPSIKKENLSSHSEMDANIAMISLSFINQDARKLKTQLE ELASHLETYQQAVVLKKTSSGQSRASLTAYIQSLKDTKQFIEKKQLDEASSAIDNLVT SWLAVEGDVVSQSKEAYTTSEENLALMKAEIGSHPEKVSKQIDEMIQLLEPIASSSYS WWDAALIPVREGMEALLVIGALLTMTKKARVTRSSTWIWGGASAGMAVSLAAGIGVTV LFSSSVFGENNFLLGGVTGVLSAVMLLYVGVWLHRNASMDKWREKINIQKSQALKKRS LLSFALIAFLAVVREGLETVIFFIGLVGKLPLTELIGGTAAGLIVLVIVGVLMIKLGM RIPLKPFFLLSMAVVLYMCVKFLGTGVHSLQLAGILPSDAESWLPSVSVLGIYPSVYS TIPQMLILLFLLIALVSEAAKHFTNGKELTK*" /label="efeU CDS" gene complement(3429991..3431436) /gene="efeU" /locus_tag="BSU_38280" /old_locus_tag="BSU38280" /label="efeU gene" promotor_-10 complement(3431470..3431489) /Source="Nicolas_upshift_promotors" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3431480) /Source="Nicolas_upshifts" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3431503..3431510) /Source="Nicolas_upshift_promotors" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3431593..3432261) /gene="thiE" /locus_tag="BSU_38290" /old_locus_tag="BSU38290" /EC_number="2.5.1.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10382260, 16291685, 19888457, 22616866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine-phosphate pyrophosphorylase (thiamine phosphate synthase)" /protein_id="NP_391708.1" /db_xref="EnsemblGenomes-Gn:BSU38290" /db_xref="EnsemblGenomes-Tr:CAB15855" /db_xref="GOA:P39594" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022998" /db_xref="InterPro:IPR034291" /db_xref="InterPro:IPR036206" /db_xref="PDB:1G4E" /db_xref="PDB:1G4P" /db_xref="PDB:1G4S" /db_xref="PDB:1G4T" /db_xref="PDB:1G67" /db_xref="PDB:1G69" /db_xref="PDB:1G6C" /db_xref="PDB:2TPS" /db_xref="PDB:3O15" /db_xref="PDB:3O16" /db_xref="SubtiList:BG10572" /db_xref="UniProtKB/Swiss-Prot:P39594" /translation="MTRISREMMKELLSVYFIMGSNNTKADPVTVVQKALKGGATLYQ FREKGGDALTGEARIKFAEKAQAACREAGVPFIVNDDVELALNLKADGIHIGQEDANA KEVRAAIGDMILGVSAHTMSEVKQAEEDGADYVGLGPIYPTETKKDTRAVQGVSLIEA VRRQGISIPIVGIGGITIDNAAPVIQAGADGVSMISAISQAEDPESAARKFREEIQTY KTGR*" /label="thiE CDS" gene complement(3431593..3432261) /gene="thiE" /locus_tag="BSU_38290" /old_locus_tag="BSU38290" /label="thiE gene" downshifts complement(3431602) /Source="Nicolas_upshifts" /id="D1982" /incds=0 /nref=44 /ntot=194 /MaxReadThrough="1.62789" /MaxDrop="4.13196" /score="10.8502035" /energy="-10" /TU="NA" /idTUdmin="U3013" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3432258..3433076) /gene="thiM" /locus_tag="BSU_38300" /old_locus_tag="BSU38300" /EC_number="2.7.1.50" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10382260, 16291685, 22938038, 28729425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10382260, 16291685, 22938038, 28729425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-(2-hydroxyethyl)-4-methylthiazole kinase" /protein_id="NP_391709.1" /db_xref="EnsemblGenomes-Gn:BSU38300" /db_xref="EnsemblGenomes-Tr:CAB15856" /db_xref="GOA:P39593" /db_xref="InterPro:IPR000417" /db_xref="InterPro:IPR029056" /db_xref="PDB:1C3Q" /db_xref="PDB:1EKK" /db_xref="PDB:1EKQ" /db_xref="PDB:1ESJ" /db_xref="PDB:1ESQ" /db_xref="SubtiList:BG10571" /db_xref="UniProtKB/Swiss-Prot:P39593" /translation="MDAQSAAKCLTAVRRHSPLVHSITNNVVTNFTANGLLALGASPV MAYAKEEVADMAKIAGALVLNIGTLSKESVEAMIIAGKSANEHGVPVILDPVGAGATP FRTESARDIIREVRLAAIRGNAAEIAHTVGVTDWLIKGVDAGEGGGDIIRLAQQAAQK LNTVIAITGEVDVIADTSHVYTLHNGHKLLTKVTGAGCLLTSVVGAFCAVEENPLFAA IAAISSYGVAAQLAAQQTADKGPGSFQIELLNKLSTVTEQDVQEWATIERVTVS*" /label="thiM CDS" gene complement(3432258..3433076) /gene="thiM" /locus_tag="BSU_38300" /old_locus_tag="BSU38300" /label="thiM gene" CDS complement(3433084..3433989) /gene="cidR" /locus_tag="BSU_38310" /old_locus_tag="BSU38310" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 23504016; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family, cidAB expression)" /protein_id="NP_391710.1" /db_xref="EnsemblGenomes-Gn:BSU38310" /db_xref="EnsemblGenomes-Tr:CAB15857" /db_xref="GOA:P39592" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10570" /db_xref="UniProtKB/Swiss-Prot:P39592" /translation="MDIRHLTYFLEVARLKSFTKASQSLYVSQPTISKMIKNLEEELG IELFYRNGRQVELTDAGHSMYVQAQEIIKSFQNLTSELNDIMEVKKGHVRIGLPPMIG SGFFPRVLGDFRENYPNVTFQLVEDGSIKVQEGVGDGSLDIGVVVLPANEDIFHSFTI VKETLMLVVHPSHRLADEKECQLRELKDEPFIFFREDFVLHNRIMTECIKAGFRPHII YETSQWDFISEMVSANLGIGLLPERICRGLDPEKVKVIPLVDPVIPWHLAIIWRKDRY LSFAARAWLEHTKSYLWDPKKDSKG*" /label="cidR CDS" gene complement(3433084..3433989) /gene="cidR" /locus_tag="BSU_38310" /old_locus_tag="BSU38310" /label="cidR gene" misc_feature complement(3433724..3433743) /Source="Nicolas_upshift_promotors" /id="U3013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.857142857142857" /psig="0.992007992007992" /xcortree=2665 /SigmaFactorBS="tgtgcaggcgcaggaaatcattaaatcatttcaaaacctgac gtcagaattaAATGATATTATGGAAGTCAAgaaagggcacgtacggattggactgccg c" /listShort="thiM, thiE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3433735) /Source="Nicolas_upshifts" /id="U3013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.857142857142857" /psig="0.992007992007992" /xcortree=2665 /SigmaFactorBS="tgtgcaggcgcaggaaatcattaaatcatttcaaaacctgac gtcagaattaAATGATATTATGGAAGTCAAgaaagggcacgtacggattggactgccg c" /listShort="thiM, thiE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3434030..3434049) /Source="Nicolas_upshift_promotors" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3434040..3434047 /Source="Nicolas_upshift_promotors" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3434051) /Source="Nicolas_upshifts" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="upshifts" upshifts 3434059 /Source="Nicolas_upshifts" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3434061..3434080 /Source="Nicolas_upshift_promotors" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3434065..3434072) /Source="Nicolas_upshift_promotors" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3434095..3434481 /gene="cidA" /locus_tag="BSU_38320" /old_locus_tag="BSU38320" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15659658, 15849754, 16850406, 22383849, 26060272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="metabolic regulator of murein hydrolases" /protein_id="NP_391711.1" /db_xref="EnsemblGenomes-Gn:BSU38320" /db_xref="EnsemblGenomes-Tr:CAB15858" /db_xref="GOA:P39591" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR023760" /db_xref="SubtiList:BG10569" /db_xref="UniProtKB/Swiss-Prot:P39591" /translation="MKKLLLTVIQIALLFIFARLINWVTALLHINIPGSIIGIVILFT LLHFNIIKLEWIELGAAWLLGELLLFFIPSAVGVIEYGDIMSKFGVSILLVVIISTFV VMVSTGTLTQLIAKRKEKKHTCSSEL*" /label="cidA CDS" gene 3434095..3434481 /gene="cidA" /locus_tag="BSU_38320" /old_locus_tag="BSU38320" /label="cidA gene" CDS 3434463..3435140 /gene="cidB" /locus_tag="BSU_38330" /old_locus_tag="BSU38330" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15659658, 15849754, 16850406, 26060272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="metabolic regulator controlling activity of murein hydrolases" /protein_id="NP_391712.2" /db_xref="EnsemblGenomes-Gn:BSU38330" /db_xref="EnsemblGenomes-Tr:CAB15859" /db_xref="GOA:P39590" /db_xref="InterPro:IPR005261" /db_xref="InterPro:IPR007300" /db_xref="SubtiList:BG10568" /db_xref="UniProtKB/Swiss-Prot:P39590" /translation="MFIGIVSLFLTVLVYLGAKKVYQRFPRVYTSPLLVTPAVLVGLL LLVNVPYESYNLGGGLLTDMLQPATVAFAIPLYKYFPVLKKYAVEIILNVAVGSCIAI ISTALIAKWLHLGTGLIDSLVPRSVTTPIAMNVSEMIGGMPAVTAVFVILTALLGTVI GPMVIRYFRIDNEIARGVLLGTSAHGAGTSKAFELSSVSGTISSVSMILAAIMTLCAA PFLLSFM*" /label="cidB CDS" gene 3434463..3435140 /gene="cidB" /locus_tag="BSU_38330" /old_locus_tag="BSU38330" /label="cidB gene" downshifts 3435112 /Source="Nicolas_upshifts" /id="D1983" /incds=0 /nref=13 /ntot=88 /MaxReadThrough="2.20109" /MaxDrop="4.23919" /score="27.0474383" /energy="-8" /TU="NA" /idTUdmin="U3015" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3435184..3435191 /Source="Nicolas_upshift_promotors" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3435202 /Source="Nicolas_upshifts" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3435205..3435224 /Source="Nicolas_upshift_promotors" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3435244..3436443 /gene="ywbF" /locus_tag="BSU_38340" /old_locus_tag="BSU38340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar permease" /protein_id="NP_391713.1" /db_xref="EnsemblGenomes-Gn:BSU38340" /db_xref="EnsemblGenomes-Tr:CAB15860" /db_xref="GOA:P39589" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR024989" /db_xref="InterPro:IPR026032" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10567" /db_xref="UniProtKB/Swiss-Prot:P39589" /translation="MHNLQVRRHYAALKGFYLFAFLGTGSIIPLLSMYLTKEQHLSGS QVGLIMSLGPIVMIFFQPFWGMLSDYTQKTKGLLAVCTSITGIIGLAYIAFDSFPLFI LIAACFAAFQSTIIPLSDSISLRYTQETNGNYGGIRLFGSLGFGVAVFAMGQVTNQLY PIHVIFIFGCAFLCIAAILASQVPGQQKTTKVNIRKGFRELISNKTFLIFMIITFTTF APNLANNTYFSLFLDKSGASLSAIGILFFIGVISEIPFMRFAQTFIDKMGLLNVIMLS GGVSLFRWALYFTAPSLWIIYATVFLQGVAIGLFIPAALQYVKKITPRHVEATALTMY AAIGNGFGNWFCTFAGGYIFDYVSIFAVYLLFGILSIAGFGLTLYLMKAEKNKHTLHQ PAVTFKP*" /label="ywbF CDS" gene 3435244..3436443 /gene="ywbF" /locus_tag="BSU_38340" /old_locus_tag="BSU38340" /label="ywbF gene" CDS 3436477..3436674 /gene="ywbE" /locus_tag="BSU_38350" /old_locus_tag="BSU38350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391714.1" /db_xref="EnsemblGenomes-Gn:BSU38350" /db_xref="EnsemblGenomes-Tr:CAB15861" /db_xref="InterPro:IPR019240" /db_xref="SubtiList:BG10566" /db_xref="UniProtKB/Swiss-Prot:P39588" /translation="MNGQERNSISKGLQVDIVLKADQKTGKLTRGTVKDILTKSNFHP HGIKVRLEDGRIGRDQQIVST*" /label="ywbE CDS" gene 3436477..3436674 /gene="ywbE" /locus_tag="BSU_38350" /old_locus_tag="BSU38350" /label="ywbE gene" downshifts 3436653 /Source="Nicolas_upshifts" /id="D1984" /incds=0 /nref=15 /ntot=205 /MaxReadThrough="1.90583" /MaxDrop="4.20528" /score="21.8132292" /energy="-12.2" /TU="NA" /idTUdmin="U3016" /TUdmin=88 /isTUend="FALSE" /label="downshifts" CDS complement(3436709..3437899) /gene="rlmI" /locus_tag="BSU_38360" /old_locus_tag="BSU38360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 18786544, 18789337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="large subunit ribosomal RNA m5C1962 methyltransferase" /protein_id="NP_391715.1" /db_xref="EnsemblGenomes-Gn:BSU38360" /db_xref="EnsemblGenomes-Tr:CAB15862" /db_xref="GOA:P39587" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019614" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG10565" /db_xref="UniProtKB/Swiss-Prot:P39587" /translation="MKLLTLKKAHAAKIKKGYPLIEKEALAGSAGHMKEGDLVDIVSE SGGEFLARGYYGLQNKGVGWTLTRNKHEQIDQAFFLSKLTKAAQARAKLFEAQDTTAF RLFNGEGDGVGGVTIDYYDGYLLIQWYSKGIYTFKDMLISALDEMDLDYKAIYEKKRF DTAGQYVEDDDFVKGRRGEFPIIIQENGIQYAVDLNEGAMTGIFLDQRHVRKAIRDRY AKGKTVLNTFSYTGAFSVAAALGGAEKTTSVDVANRSLAKTIEQFSVNKLDYEAHDIK VMDVFNYFSYAAKKDLRFDLIILDPPSFARTKKRTFSAAKDYKNLLKETIAITADKGV IVASTNSSAFGMKKFKGFIDAAFKETNERYTIIEEFTLPEDFKTISAFPEGNYLKVVL LQKK*" /label="rlmI CDS" gene complement(3436709..3437899) /gene="rlmI" /locus_tag="BSU_38360" /old_locus_tag="BSU38360" /label="rlmI gene" downshifts complement(3436724) /Source="Nicolas_upshifts" /id="D1985" /incds=0 /nref=5 /ntot=127 /MaxReadThrough="0.0525399999999996" /MaxDrop="4.51664" /score="48.4884619" /energy="-14.3" /TU="NA" /idTUdmin="U3017" /TUdmin=71 /isTUend="FALSE" /label="downshifts" downshifts complement(3436808) /Source="Nicolas_upshifts" /id="D1986" /incds=1 /nref=42 /ntot=233 /MaxReadThrough="2.99734" /MaxDrop="3.89369" /score="48.4884619" /energy="-14.3" /TU="NA" /idTUdmin="U3017" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" misc_feature complement(3437923..3437942) /Source="Nicolas_upshift_promotors" /id="U3017" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig=1 /xcortree=1883 /SigmaFactorBS="tttttgtctatcgtagaaaaacctttcctttctgtcaatgca gacatcttggcgtttTGTGGTACCATAAGAGAAAGcaaacggaaagaggacgacatat a" /listShort="ywbD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3437939) /Source="Nicolas_upshifts" /id="U3017" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig=1 /xcortree=1883 /SigmaFactorBS="tttttgtctatcgtagaaaaacctttcctttctgtcaatgca gacatcttggcgtttTGTGGTACCATAAGAGAAAGcaaacggaaagaggacgacatat a" /listShort="ywbD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3437959..3437966 /Source="Nicolas_upshift_promotors" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3437975 /Source="Nicolas_upshifts" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3437980..3437999 /Source="Nicolas_upshift_promotors" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3438020..3438400 /gene="glxA" /locus_tag="BSU_38370" /old_locus_tag="BSU38370" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:24330391, 25283443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24330391, 25283443; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyoxalase I; hemithioacetal-bacillithiol lactoyl-bacillithiol formation" /protein_id="NP_391716.1" /db_xref="EnsemblGenomes-Gn:BSU38370" /db_xref="EnsemblGenomes-Tr:CAB15863" /db_xref="GOA:P39586" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG10564" /db_xref="UniProtKB/Swiss-Prot:P39586" /translation="MAKRIDHTGIMVRDINASITFYEEVLGMKLKDRITHTNGVIELA FLGFEDGPETEIELIQGYSSELPAEGKVHHIALLTDDIAAEYTKAEKMNAKFIDEEIT TLPNGYRYFYIEGPDGEWIEFFQR*" /label="glxA CDS" gene 3438020..3438400 /gene="glxA" /locus_tag="BSU_38370" /old_locus_tag="BSU38370" /label="glxA gene" downshifts 3438298 /Source="Nicolas_upshifts" /id="D1987" /incds=1 /nref=14 /ntot=215 /MaxReadThrough="3.76076" /MaxDrop="3.68951" /score="-8.22053631" /energy="-7.4" /TU="U3018" /idTUdmin="U3018" /TUdmin="-357" /isTUend="FALSE" /label="downshifts" downshifts 3438369 /Source="Nicolas_upshifts" /id="D1988" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="3.05249" /MaxDrop="3.56101" /score="-8.22053631" /energy="-7.4" /TU="U3018" /idTUdmin="U3018" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" CDS complement(3438438..3439115) /gene="ywbB" /locus_tag="BSU_38380" /old_locus_tag="BSU38380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391717.1" /db_xref="EnsemblGenomes-Gn:BSU38380" /db_xref="EnsemblGenomes-Tr:CAB15864" /db_xref="InterPro:IPR024250" /db_xref="SubtiList:BG10563" /db_xref="UniProtKB/Swiss-Prot:P39585" /translation="MLDYIWLDDESPILQQVPVEYSSAALIFSPFIQMPEGWENAKRK NDYEHIYPNDNEIRGIGKAVSWKKVMSSCGFQTHAELALALMTSIGALRDEFAREDLA EVLHENINGDLYYPSEDHISNFHIPSLVKVLGANGSNRFYYAEPIVENRGVLDITEAN LRTVLDEAATELVLTDEKMDFVFMSVYDSFINVFLAKDKNIHELVERMGWEAMICDES TYISWYR*" /label="ywbB CDS" gene complement(3438438..3439115) /gene="ywbB" /locus_tag="BSU_38380" /old_locus_tag="BSU38380" /label="ywbB gene" downshifts complement(3438445) /Source="Nicolas_upshifts" /id="D1989" /incds=0 /nref=6 /ntot=156 /MaxReadThrough="0.15283" /MaxDrop="5.41362" /score="0.491291944" /energy="-11.7" /TU="NA" /idTUdmin="U3020" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3439124..3439143) /Source="Nicolas_upshift_promotors" /id="U3019" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig="0.997002997002997" /xcortree=2178 /SigmaFactorBS="gataaaaatgtgatgtgatagatgatcagcctgtcatagggc tgatcaTCTCTTTcaaacgaaaggAATGTTAGAATATGTAAAGGaggtgcgcatgcta g" /listShort="ywbB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3439149) /Source="Nicolas_upshifts" /id="U3019" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig="0.997002997002997" /xcortree=2178 /SigmaFactorBS="gataaaaatgtgatgtgatagatgatcagcctgtcatagggc tgatcaTCTCTTTcaaacgaaaggAATGTTAGAATATGTAAAGGaggtgcgcatgcta g" /listShort="ywbB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3439155..3439161) /Source="Nicolas_upshift_promotors" /id="U3019" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig="0.997002997002997" /xcortree=2178 /SigmaFactorBS="gataaaaatgtgatgtgatagatgatcagcctgtcatagggc tgatcaTCTCTTTcaaacgaaaggAATGTTAGAATATGTAAAGGaggtgcgcatgcta g" /listShort="ywbB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3439192..3440526) /gene="ywbA" /locus_tag="BSU_38390" /old_locus_tag="BSU38390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8990303, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cellobiose phosphotransferase system enzyme IIC permease component" /protein_id="NP_391718.1" /db_xref="EnsemblGenomes-Gn:BSU38390" /db_xref="EnsemblGenomes-Tr:CAB15865" /db_xref="GOA:P39584" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004501" /db_xref="InterPro:IPR004796" /db_xref="SubtiList:BG10562" /db_xref="UniProtKB/Swiss-Prot:P39584" /translation="MSTFTRVMEEKIMPVAGKIAGQRHLSALRDGIILTMPLIIIGSV FLILTSLPIPGYADFMASVFGNEWADKLGYPVNASFDIMAMIAAFGIAYRLAESYGVD ALSAGAISIAAFLLATPFEVPFTPHGSTESIMVGGGIPITLLGSKGLFVAMLIALFST EIYRYIIQKNIVFKMPDGVPPAVSKSFVALIPGFIIVLLVWLARLLIEMTPFQSLHNV VGDLLGTPLSILGGSLGGSLIAEFVQMLLWSCGIHGASIIGGIMAPIWYGAMDANRLA FQAGEALPSIFTTQFFQIWINVGGSGATLALVLTMLVRSRSKQMKQLGRLGIGPALFN INEPIIFGMPIVMNPLLIVPFIIAPLLTITATYIGMSTGLVARPAGIAVPWTMPPLIS GYLATGGKVSGAVMQLVNLLITCAIYYPFFRIWDHQKWREESAVESGDKNVM*" /label="ywbA CDS" gene complement(3439192..3440526) /gene="ywbA" /locus_tag="BSU_38390" /old_locus_tag="BSU38390" /label="ywbA gene" misc_feature complement(3440574..3440592) /Source="Nicolas_upshift_promotors" /id="U3020" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.596403596403596" /psig="0.596403596403596" /xcortree=1254 /SigmaFactorBS="tttagcaaaatgcagattttttccgcatgaagaggaaatttt ccaaatgaatttgtaagcgttttCAAAATAAGATAAAGAAAAcattgcggaggttgtt c" /listShort="ywbA, ywbB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3440597) /Source="Nicolas_upshifts" /id="U3020" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.596403596403596" /psig="0.596403596403596" /xcortree=1254 /SigmaFactorBS="tttagcaaaatgcagattttttccgcatgaagaggaaatttt ccaaatgaatttgtaagcgttttCAAAATAAGATAAAGAAAAcattgcggaggttgtt c" /listShort="ywbA, ywbB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3440691..3440698 /Source="Nicolas_upshift_promotors" /id="U3021" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=2809 /SigmaFactorBS="ctgcattttgctaaacaaccctgcccatgaaaaattttttcc ttcttaCTATTAATctctctttttttcTCCGATATATATATCAAACatcatagaaaaa g" /listShort="epr" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3440703 /Source="Nicolas_upshifts" /id="U3021" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=2809 /SigmaFactorBS="ctgcattttgctaaacaaccctgcccatgaaaaattttttcc ttcttaCTATTAATctctctttttttcTCCGATATATATATCAAACatcatagaaaaa g" /listShort="epr" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3440712..3440730 /Source="Nicolas_upshift_promotors" /id="U3021" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=2809 /SigmaFactorBS="ctgcattttgctaaacaaccctgcccatgaaaaattttttcc ttcttaCTATTAATctctctttttttcTCCGATATATATATCAAACatcatagaaaaa g" /listShort="epr" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3440754..3442691 /gene="epr" /locus_tag="BSU_38400" /old_locus_tag="BSU38400" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1938892, 2116590, 16553828, 17666034, 19416356, 23660663, 25966269" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1938892, 2116590, 16553828, 17666034, 19416356, 23660663, 25966269; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular serine protease" /protein_id="NP_391719.1" /db_xref="EnsemblGenomes-Gn:BSU38400" /db_xref="EnsemblGenomes-Tr:CAB15866" /db_xref="GOA:P16396" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR009020" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034202" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="SubtiList:BG10561" /db_xref="UniProtKB/Swiss-Prot:P16396" /translation="MKNMSCKLVVSVTLFFSFLTIGPLAHAQNSSEKEVIVVYKNKAG KETILDSDADVEQQYKHLPAVAVTADQETVKELKQDPDILYVENNVSFTAADSTDFKV LSDGTDTSDNFEQWNLEPIQVKQAWKAGLTGKNIKIAVIDSGISPHDDLSIAGGYSAV SYTSSYKDDNGHGTHVAGIIGAKHNGYGIDGIAPEAQIYAVKALDQNGSGDLQSLLQG IDWSIANRMDIVNMSLGTTSDSKILHDAVNKAYEQGVLLVAASGNDGNGKPVNYPAAY SSVVAVSATNEKNQLASFSTTGDEVEFSAPGTNITSTYLNQYYATGSGTSQATPHAAA MFALLKQRDPAETNVQLREEMRKNIVDLGTAGRDQQFGYGLIQYKAQATDSAYAAAEQ AVKKAEQTKAQIDINKARELISQLPNSDAKTALHKRLDKVQSYRNVKDAKDKVAKAEK YKTQQTVDTAQTAINKLPNGTDKKNLQKRLDQVKRYIASKQAKDKVAKAEKSKKKTDV DSAQSAIGKLPASSEKTSLQKRLNKVKSTNLKTAQQSVSAAEKKSTDANAAKAQSAVN QLQAGKDKTALQKRLDKVKKKVAAAEAKKVETAKAKVKKAEKDKTKKSKTSAQSAVNQ LKASNEKTKLQKRLNAVKPKK*" /label="epr CDS" gene 3440754..3442691 /gene="epr" /locus_tag="BSU_38400" /old_locus_tag="BSU38400" /label="epr gene" promotor_-10 complement(3441898..3441917) /Source="Nicolas_upshift_promotors" /id="U3022" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.81018981018981" /psig="0.81018981018981" /xcortree=1236 /SigmaFactorBS="tgcttttgtttgttccgcttTTTTCACCGcttgctctgctgc CGCGTACGCTGAATCTGTTGcctgtgctttatactggattaagccgtagccaaattgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3441899) /Source="Nicolas_upshifts" /id="U3022" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.81018981018981" /psig="0.81018981018981" /xcortree=1236 /SigmaFactorBS="tgcttttgtttgttccgcttTTTTCACCGcttgctctgctgc CGCGTACGCTGAATCTGTTGcctgtgctttatactggattaagccgtagccaaattgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3441931..3441939) /Source="Nicolas_upshift_promotors" /id="U3022" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.81018981018981" /psig="0.81018981018981" /xcortree=1236 /SigmaFactorBS="tgcttttgtttgttccgcttTTTTCACCGcttgctctgctgc CGCGTACGCTGAATCTGTTGcctgtgctttatactggattaagccgtagccaaattgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3442681 /Source="Nicolas_upshifts" /id="D1990" /incds=0 /nref=175 /ntot=224 /MaxReadThrough="1.26567" /MaxDrop="6.00181" /score="15.6173594" /energy="-13" /TU="NA" /idTUdmin="U3021" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3442794..3442801 /Source="Nicolas_upshift_promotors" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3442816..3442835 /Source="Nicolas_upshift_promotors" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3442835 /Source="Nicolas_upshifts" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3443047..3443054 /Source="Nicolas_upshift_promotors" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3443067..3443086 /Source="Nicolas_upshift_promotors" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3443067 /Source="Nicolas_upshifts" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="upshifts" CDS 3443119..3444498 /gene="sacX" /locus_tag="BSU_38410" /old_locus_tag="BSU38410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11580842, 1400159, 8535520, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11580842, 1400159, 8535520, 15849754, 16850406; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of SacY" /protein_id="NP_391720.1" /db_xref="EnsemblGenomes-Gn:BSU38410" /db_xref="EnsemblGenomes-Tr:CAB15867" /db_xref="GOA:P15400" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR010973" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10560" /db_xref="UniProtKB/Swiss-Prot:P15400" /translation="MHKEIAKELLLLAGGKNNIISISHCTTRLRFDVKDETKIDIHAI ENLQGVQGTFFRYGLFQIIFGAGVVNKIYKEVVHVWETAPSEEPVHQKKASRKLNPAA AFAKTLSDIFVPIIPAITASGLLMGLIGMIKVFHWFAAGSPWIKMLDLVSSTAFILLP ILVGFSAARQFGSNPYLGAVIAGLLTHPDLLDPSMLGSKTPSSLDIWGLHIPMMGYQG SMIPILLSVFVMSKIEKLLKSIVPKSLDVVIIPFITVMVTGCLALIVMNPAASIIGQI MTQSIVYIYDHAGIAAGALFGGIYSTIVLSGLHHSFYAIEATLLANPHVGVNFLVPIW SMANVAQGGAGLAVFLKTKQSSLKKIALPASLTAFLGIVEPIVFGVNLKLIRPFIGAA IGGAIGGAYVVAVQVVANSYGLTGIPMISIVLPFGAANFVHYMIGFLIAAVSAFIATL FLGFKEETE*" /label="sacX CDS" gene 3443119..3444498 /gene="sacX" /locus_tag="BSU_38410" /old_locus_tag="BSU38410" /label="sacX gene" S_feature complement(3444207..3445410) /Source="Nicolas_S_feature" /locus_tag="new_3943322_3944525_c" /HighExp="Etha, B36, B60, M9-stat, Salt, Sw, LoTm, C30, Gly, Heat" /AntisenseName="sacY" /AntisenseCor="-0.177403958488455" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1477" CDS 3444552..3445394 /gene="sacY" /locus_tag="BSU_38420" /old_locus_tag="BSU38420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9305644, 9457872, 11580842, 12079345, 15528654, 21278164" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9305644, 9457872, 11580842, 12079345, 15528654, 21278164; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator" /protein_id="NP_391721.1" /db_xref="EnsemblGenomes-Gn:BSU38420" /db_xref="EnsemblGenomes-Tr:CAB15868" /db_xref="GOA:P15401" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:1AUU" /db_xref="SubtiList:BG10559" /db_xref="UniProtKB/Swiss-Prot:P15401" /translation="MKIKRILNHNAIVVKDQNEEKILLGAGIAFNKKKNDIVDPSKIE KTFIRKDTPDYKQFEEILETLPEDHIQISEQIISHAEKELNIKINERIHVAFSDHLSF AIERLSNGMVIKNPLLNEIKVLYPKEFQIGLWARALIKDKLGIHIPDDEIGNIAMHIH TARNNAGDMTQTLDITTMIRDIIEIIEIQLSINIVEDTISYERLVTHLRFAIQHIKAG ESIYELDAEMIDIIKEKFKDAFLCALSIGTFVKKEYGFEFPEKELCYIAMHIQRFYQR SVAR*" /label="sacY CDS" gene 3444552..3445394 /gene="sacY" /locus_tag="BSU_38420" /old_locus_tag="BSU38420" /label="sacY gene" CDS complement(3445445..3446305) /gene="gspA" /locus_tag="BSU_38430" /old_locus_tag="BSU38430" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11377871, 19659723; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyl transferase (general stress protein)" /protein_id="NP_391722.1" /db_xref="EnsemblGenomes-Gn:BSU38430" /db_xref="EnsemblGenomes-Tr:CAB15869" /db_xref="GOA:P25148" /db_xref="InterPro:IPR002495" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10558" /db_xref="UniProtKB/Swiss-Prot:P25148" /translation="MRKDEIMHIVSCADDNYARHLGGMFVSLLTNMDQEREVKLYVID GGIKPDNKKRLEETTLKFGVPIEFLEVDTNMYEHAVESSHITKAAYYRISIPDLIKDE SIKRMIYIDCDALVLEDISKLWDLDIAPYTVAAVEDAGQHERLKEMNVTDTGKYFNSG IMIIDFESWRKQNITEKVINFINEHPDEDFLVLHDQDALNAILYDQWYELHPRWNAQT YIMLKLKTPSTLLGRKQYNETRENPAIVHFCGGEKPWNSNTKHPYRDEYFHYMSYTKW NTIGNPAINQ*" /label="gspA CDS" gene complement(3445445..3446305) /gene="gspA" /locus_tag="BSU_38430" /old_locus_tag="BSU38430" /label="gspA gene" downshifts complement(3445455) /Source="Nicolas_upshifts" /id="D1991" /incds=0 /nref=73 /ntot=227 /MaxReadThrough="5.61926" /MaxDrop="7.47527" /score="21.8603429" /energy="-10.6" /TU="U3025" /idTUdmin="U3025" /TUdmin="-1224" /isTUend="FALSE" /label="downshifts" downshifts 3446289 /Source="Nicolas_upshifts" /id="D1992" /incds=0 /nref=8 /ntot=30 /MaxReadThrough="1.49599" /MaxDrop="5.33818" /score="10.6843241" /energy="-4.5" /TU="NA" /idTUdmin="U3026" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3446327..3446345) /Source="Nicolas_upshift_promotors" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3446345) /Source="Nicolas_upshifts" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3446360..3446366) /Source="Nicolas_upshift_promotors" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3446415..3447128) /gene="ywaF" /locus_tag="BSU_38440" /old_locus_tag="BSU38440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391723.1" /db_xref="EnsemblGenomes-Gn:BSU38440" /db_xref="EnsemblGenomes-Tr:CAB15870" /db_xref="GOA:P25149" /db_xref="InterPro:IPR011737" /db_xref="SubtiList:BG10557" /db_xref="UniProtKB/Swiss-Prot:P25149" /translation="MQKYVQSDYKHDPFHLFSTEHVVTLAIISLLAILLFLFQDEVKQ PRASRFLRSLFVFLLLGSQIGYQIWMVATDRWSVRTSLPLQLSDLSVYLSAIMLVTKS RKLFVFLFFVGIGSSIQALATPDLGMFSFPHIRYILFFISHGSVFLSCLLMAVIGTYR MGQRSLWVTVLLVNVYGVCIFLIDRWLGANYMYLTKKPGGSSLLDVLGPWPWYIVSAE AITIASFFILYWLYRIFKK*" /label="ywaF CDS" gene complement(3446415..3447128) /gene="ywaF" /locus_tag="BSU_38440" /old_locus_tag="BSU38440" /label="ywaF gene" promotor_-35 3446530..3446531 /Source="Nicolas_upshift_promotors" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3446551..3446568 /Source="Nicolas_upshift_promotors" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3446553 /Source="Nicolas_upshifts" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3447156..3447167) /Source="Nicolas_upshift_promotors" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3447157) /Source="Nicolas_upshifts" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3447182..3447188) /Source="Nicolas_upshift_promotors" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3447203..3447209 /Source="Nicolas_upshift_promotors" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3447224..3447243 /Source="Nicolas_upshift_promotors" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3447234 /Source="Nicolas_upshifts" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="upshifts" CDS 3447279..3447794 /gene="tyrZR" /locus_tag="BSU_38450" /old_locus_tag="BSU38450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:25733610" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25733610; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator controlling expressionof tyrZ" /protein_id="NP_391724.1" /db_xref="EnsemblGenomes-Gn:BSU38450" /db_xref="EnsemblGenomes-Tr:CAB15871" /db_xref="GOA:P25150" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10556" /db_xref="UniProtKB/Swiss-Prot:P25150" /translation="MERSHQHQQLRKEEHDTLSKLKQMPVESLNLEAISIATNLYRSA QRLRVKMETEVLSTYNLSWTAFSILYDLWVWGALETRKIAELSGISTATASNVIKTLE KKSFCRKSIDTRDRRLVFVSITDSGKQAIEELYPEFHKGETELIAGMTKDEQKILTGL LRKVADNLHTT*" /label="tyrZR CDS" gene 3447279..3447794 /gene="tyrZR" /locus_tag="BSU_38450" /old_locus_tag="BSU38450" /label="tyrZR gene" misc_RNA 3447795..3448001 /gene="tboYB" /locus_tag="BSU_misc_RNA_59" /product="T-box riboswitch specific of tyrosine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:8045882, 9098041, 10943892, 11842119, 12165569, 12547201, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 9098041, 10943892, 11842119, 12165569, 12547201, 1317842; Product type n: RNA" /function="16.3: Control" /label="tboYB RNA" gene 3447795..3448001 /gene="tboYB" /locus_tag="BSU_misc_RNA_59" /label="tboYB gene" downshifts 3447961 /Source="Nicolas_upshifts" /id="D1993" /incds=0 /nref=15 /ntot=112 /MaxReadThrough="1.84575" /MaxDrop="4.56656" /score="23.8000948" /energy="-14.5" /TU="NA" /idTUdmin="U3028" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3448043..3449284 /gene="tyrZ" /locus_tag="BSU_38460" /old_locus_tag="BSU38460" /EC_number="6.1.1.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1735721, 1806041, 25733610" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1735721, 1806041, 25733610; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tyrosyl-tRNA synthetase" /protein_id="NP_391725.1" /db_xref="EnsemblGenomes-Gn:BSU38460" /db_xref="EnsemblGenomes-Tr:CAB15872" /db_xref="GOA:P25151" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002307" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024088" /db_xref="InterPro:IPR024108" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10555" /db_xref="UniProtKB/Swiss-Prot:P25151" /translation="MMRTFEQLTASQQKEVERQLQLYMTGAHEVIPPEELKAKLVKSI STGTPLKIKLGLDPSAPDVHLGHTVVLNKLRQFQENGHIVQLLIGDFTGKIGDPTGKS AARKQLTDEEVQHNAKTYFEQFGKVLDPEKVELHYNSKWLKTLNLEDVIELAGKITVA RLMERDDFEERIAMQKPISLHEFFYPLMQGYDSVVLESDIELGGTDQHFNVLMGRHFQ ERYNKEKQVVILMPLLEGLDGVEKMSKSKHNYIGINEHPNDMYGKTMSLPDSLMKKYI HLATDLELEEKKQLVKDLETGAVHPRDAKMLLARTIVRMYHGEKAAEAAEHSFKTVFQ ENSLPEDIPAVNWKGEKTIAMIDLLVKLKLLSSKSEARRMIQNGGVRIDGEKVTDVHA KAEIRENMIIQVGKRKFLKLQ*" /label="tyrZ CDS" gene 3448043..3449284 /gene="tyrZ" /locus_tag="BSU_38460" /old_locus_tag="BSU38460" /label="tyrZ gene" promotor_-35 3449375..3449383 /Source="Nicolas_upshift_promotors" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3449394..3449412 /Source="Nicolas_upshift_promotors" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3449405 /Source="Nicolas_upshifts" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="upshifts" CDS 3449440..3450807 /gene="eapD" /locus_tag="BSU_38470" /old_locus_tag="BSU38470" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15668014, 23426795, 26898926, 28257579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15668014, 23426795, 26898926, 28257579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported double-zinc aminopeptidase" /protein_id="NP_391726.1" /db_xref="EnsemblGenomes-Gn:BSU38470" /db_xref="EnsemblGenomes-Tr:CAB15873" /db_xref="GOA:P25152" /db_xref="InterPro:IPR003137" /db_xref="InterPro:IPR007484" /db_xref="SubtiList:BG10554" /db_xref="UniProtKB/Swiss-Prot:P25152" /translation="MKKLLTVMTMAVLTAGTLLLPAQSVTPAAHAVQISNSERELPFK AKHAYSTISQLSEAIGPRIAGTAAEKKSALLIASSMRKLKLDVKVQRFNIPDRLEGTL SSAGRDILLQAASGSAPTEEQGLTAPLYNAGLGYQKDFTADAKGKIALISRGDLTYYE KAKNAEAAGAKAVIIYNNKESLVPMTPNLSGNKVGIPVVGIKKEDGEALTQQKEATLK LKAFTNQTSQNIIGIKKPKNIKHPDIVYVTAHYDSVPFSPGANDNGSGTSVMLEMARV LKSVPSDKEIRFIAFGAEELGLLGSSHYVDHLSEKELKRSEVNFNLDMVGTSWEKASE LYVNTLDGQSNYVWESSRTAAEKIGFDSLSLTQGGSSDHVPFHEAGIDSANFIWGDPE TEEVEPWYHTPEDSIEHISKERLQQAGDLVTAAVYEAVKKEKKPKTIKKQMKAKASDI FEDIK*" /label="eapD CDS" gene 3449440..3450807 /gene="eapD" /locus_tag="BSU_38470" /old_locus_tag="BSU38470" /label="eapD gene" downshifts 3450784 /Source="Nicolas_upshifts" /id="D1994" /incds=0 /nref=3 /ntot=37 /MaxReadThrough="1.38814" /MaxDrop="6.05871" /score="27.7635079" /energy="-13.3" /TU="NA" /idTUdmin="U3029" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(3450837..3451469) /gene="relQ" /locus_tag="BSU_38480" /old_locus_tag="BSU38480" /EC_number="2.7.6.5" /function="16.7: Manage energy" /function="16.3: Control" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:17714452, 18067544, 19447912, 22333191, 22950019, 24163341, 25331430, 26211718" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17714452, 18067544, 19447912, 22333191, 22950019, 24163341, 25331430, 26211718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(p)ppGpp synthetase" /protein_id="NP_391727.1" /db_xref="EnsemblGenomes-Gn:BSU38480" /db_xref="EnsemblGenomes-Tr:CAB15874" /db_xref="GOA:P39583" /db_xref="InterPro:IPR007685" /db_xref="SubtiList:BG10553" /db_xref="UniProtKB/Swiss-Prot:P39583" /translation="MDLSVTHMDDLKTVMEDWKNELLVYKFALDALDTKFSIISQEYN LIHGHNPIEHTKSRVKSFESIVNKLMRKGCEITTKEMKEHIHDIAGVRIICSFISDIY NVVNVLKQHEDLRIVKVKDYIQTPKPNGYRSLHLIIEMPVNLTNRVEYVKAEIQIRTI AMDFWASLEHKIYYKLNNDVPKQLTDELKEAAEIAHYLDEKMLGIKKEVD*" /label="relQ CDS" gene complement(3450837..3451469) /gene="relQ" /locus_tag="BSU_38480" /old_locus_tag="BSU38480" /label="relQ gene" downshifts complement(3450855) /Source="Nicolas_upshifts" /id="D1995" /incds=0 /nref=200 /ntot=257 /MaxReadThrough="2.49976" /MaxDrop="5.49802" /score="47.236042" /energy="-13.3" /TU="NA" /idTUdmin="U3030" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3451505..3451520) /Source="Nicolas_upshift_promotors" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3451513) /Source="Nicolas_upshifts" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3451533..3451541) /Source="Nicolas_upshift_promotors" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3451611..3452546) /gene="menA" /locus_tag="BSU_38490" /old_locus_tag="BSU38490" /EC_number="2.5.1.74" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6780514, 9573170, 12682299, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,4-dihydroxy-2-naphthoate octaprenyltransferase" /protein_id="NP_391728.1" /db_xref="EnsemblGenomes-Gn:BSU38490" /db_xref="EnsemblGenomes-Tr:CAB15875" /db_xref="GOA:P39582" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR004657" /db_xref="InterPro:IPR026046" /db_xref="SubtiList:BG10552" /db_xref="UniProtKB/Swiss-Prot:P39582" /translation="MNQTNKGEGQTAPQKESMGQILWQLTRPHTLTASFVPVLLGTVL AMFYVKVDLLLFLAMLFSCLWIQIATNLFNEYYDFKRGLDTAESVGIGGAIVRHGMKP KTILQLALASYGIAILLGVYICASSSWWLALIGLVGMAIGYLYTGGPLPIAYTPFGEL FSGICMGSVFVLISFFIQTDKINMQSILISIPIAILVGAINLSNNIRDIEEDKKGGRK TLAILMGHKGAVTLLAASFAVAYIWVVGLVITGAASPWLFVVFLSVPKPVQAVKGFVQ NEMPMNMIVAMKSTAQTNTFFGFLLSIGLLISYFR*" /label="menA CDS" gene complement(3451611..3452546) /gene="menA" /locus_tag="BSU_38490" /old_locus_tag="BSU38490" /label="menA gene" downshifts complement(3451623) /Source="Nicolas_upshifts" /id="D1996" /incds=0 /nref=10 /ntot=113 /MaxReadThrough="3.08081" /MaxDrop="4.6874" /score="16.8971767" /energy="-8.5" /TU="NA" /idTUdmin="U3032" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3452290..3452299 /Source="Nicolas_upshift_promotors" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3452313..3452332 /Source="Nicolas_upshift_promotors" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3452317 /Source="Nicolas_upshifts" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3452547..3452634) /Source="Nicolas_S_feature" /locus_tag="new_3951662_3951749_c" /HighExp="LBGstat, Paraq, G180, LBGexp, G135, Oxctl, C30, Cold, Diami, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.81271400000000005" /TUshortSig="SigA, Sig-" /TUshortPSig="0.999, 0.498" /TUlongSig="NA" /TUlongPSig="NA" /label="S1478" promotor_-10 complement(3452617..3452636) /Source="Nicolas_upshift_promotors" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3452634) /Source="Nicolas_upshifts" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3452652..3452656) /Source="Nicolas_upshift_promotors" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3452679..3452691) /Source="Nicolas_upshift_promotors" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3452679) /Source="Nicolas_upshifts" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3452706..3452712) /Source="Nicolas_upshift_promotors" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3452709..3452843) /locus_tag="BSU_38495" /old_locus_tag="BSU38495" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514012.1" /translation="MECFELIHNKGKDTWSQKIFLTFKKCNVLKKIFLYLFVQVKAET *" /label="hypothetical protein CDS" gene complement(3452709..3452843) /locus_tag="BSU_38495" /old_locus_tag="BSU38495" /label="gene" promotor_-35 3452790..3452797 /Source="Nicolas_upshift_promotors" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="promotor_-35" promotor_-10 3452811..3452830 /Source="Nicolas_upshift_promotors" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="promotor_-10" upshifts 3452820 /Source="Nicolas_upshifts" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="upshifts" S_feature 3452823..3452927 /Source="Nicolas_S_feature" /locus_tag="new_3951938_3952042" /HighExp="H2O2, Paraq, Oxctl, G180, G150, C30, G135, LBGstat, dia15, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1479" promotor_-35 3452922..3452931 /Source="Nicolas_upshift_promotors" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3452929 /Source="Nicolas_upshifts" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3452943..3452958 /Source="Nicolas_upshift_promotors" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3452965) /Source="Nicolas_upshifts" /id="U3036" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.976023976023976" /psig="0.001998001998002" /xcortree=298 /SigmaFactorBS="tttttcatacagctgtttcattaattgcagcatatcaaaaat tcCCTTCCCGTTTTTTCgacaatcacatgattatttgacgatcagatgctcaaaaagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3452967..3452981) /Source="Nicolas_upshift_promotors" /id="U3036" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.976023976023976" /psig="0.001998001998002" /xcortree=298 /SigmaFactorBS="tttttcatacagctgtttcattaattgcagcatatcaaaaat tcCCTTCCCGTTTTTTCgacaatcacatgattatttgacgatcagatgctcaaaaagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3452993..3453142 /gene="ywzH" /locus_tag="BSU_38499" /old_locus_tag="BSU38499" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical membrane protein" /protein_id="YP_003097795.1" /db_xref="EnsemblGenomes-Gn:BSU38499" /db_xref="EnsemblGenomes-Tr:CAX52708" /db_xref="GOA:C0H3T3" /db_xref="InterPro:IPR021008" /db_xref="UniProtKB/Swiss-Prot:C0H3T3" /translation="MLQLMKQLYEKPAVKWTCHTGFYLMILLVLFFMYGFHTANTGSY IYNDF*" /label="ywzH CDS" gene 3452993..3453142 /gene="ywzH" /locus_tag="BSU_38499" /old_locus_tag="BSU38499" /label="ywzH gene" CDS 3453160..3454671 /gene="dltA" /locus_tag="BSU_38500" /old_locus_tag="BSU38500" /EC_number="6.1.1.13" /function="16.8: Protect" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7797557, 11222605, 14665680, 15955059, 18847223, 19324056, 23858088" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7797557, 11222605, 14665680, 15955059, 18847223, 19324056, 23858088; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine:D-alanyl-carrier protein ligase subunit" /protein_id="NP_391729.1" /db_xref="EnsemblGenomes-Gn:BSU38500" /db_xref="EnsemblGenomes-Tr:CAB15876" /db_xref="GOA:P39581" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR010072" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:3E7W" /db_xref="PDB:3E7X" /db_xref="SubtiList:BG10551" /db_xref="UniProtKB/Swiss-Prot:P39581" /translation="MKLLHAIQTHAETYPQTDAFRSQGQSLTYQELWEQSDRAAAAIQ KRISGEKKSPILVYGHMEPHMIVSFLGSVKAGHPYIPVDLSIPSERIAKIIESSGAEL LIHAAGLSIDAVGQQIQTVSAEELLENEGGSVSQDQWVKEHETFYIIYTSGSTGNPKG VQISAANLQSFTDWICADFPVSGGKIFLNQAPFSFDLSVMDLYPCLQSGGTLHCVTKD AVNKPKVLFEELKKSGLNVWTSTPSFVQMCLMDPGFSQDLLPHADTFMFCGEVLPVSV AKALLERFPKAKIFNTYGPTEATVAVTSVEITNDVISRSESLPVGFAKPDMNIFIMDE EGQPLPEGEKGEIVIAGPSVSRGYLGEPELTEKAFFSHEGQWAYRTGDAGFIQDGQIF CQGRLDFQIKLHGYRMELEEIEFHVRQSQYVRSAVVIPYQPNGTVEYLIAAIVPEEHE FEKEFQLTSAIKKELAASLPAYMIPRKFIYQDHIQMTANGKIDRKRIGEEVLV*" /label="dltA CDS" gene 3453160..3454671 /gene="dltA" /locus_tag="BSU_38500" /old_locus_tag="BSU38500" /label="dltA gene" CDS 3454668..3455855 /gene="dltB" /locus_tag="BSU_38510" /old_locus_tag="BSU38510" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222605, 12028417, 14665680, 15849754, 16850406, 17263852; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative D-alanine transferase from DCP to undecaprenylphosphate for lipoteichoic acid and wall teichoic acid" /protein_id="NP_391730.1" /db_xref="EnsemblGenomes-Gn:BSU38510" /db_xref="EnsemblGenomes-Tr:CAB15877" /db_xref="GOA:P39580" /db_xref="InterPro:IPR004299" /db_xref="InterPro:IPR024024" /db_xref="InterPro:IPR024194" /db_xref="SubtiList:BG10550" /db_xref="UniProtKB/Swiss-Prot:P39580" /translation="MTPYSSFLFFILLGILLLPTIILGLNGKRFQAYNMFISIIILAL IFSHDLHGVIALCLFTIWQVLLISGYLAYRQKANSGFVFCGAVIASILPLFLSKIWPF LSHPQPHHPPHNLISFLGISYLTFKGVQLIMEARDGLLKEQLPLHRLLYFILFFPTIS SGPIDRYRRFVKDEQKAWTKEEYADLLYTGIHKIFIGFLYKFIIGYAINTYFIMNLPA ITHNKILGNLLYMYGYSMYLFFDFAGYTMFAVGVSYIMGIKSPENFNKPFISKNIKDF WNRWHMSLSFWFRDYVFMRFVFWMTKKKWIKNRMAVSNIGYFLLFMLMGVWHGLAPQY IIYGLYHAVLMTCYNFFEKWNKKYKWLPSNRWTTILAIVITFHFVCFGFYIFSGKPFH HHH*" /label="dltB CDS" gene 3454668..3455855 /gene="dltB" /locus_tag="BSU_38510" /old_locus_tag="BSU38510" /label="dltB gene" CDS 3455872..3456108 /gene="dltC" /locus_tag="BSU_38520" /old_locus_tag="BSU38520" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7797557, 11222605, 14665680, 15955059, 26193422" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7797557, 11222605, 14665680, 15955059, 26193422; Product type c: carrier" /codon_start=1 /transl_table=11 /product="D-alanyl carrier protein" /protein_id="NP_391731.1" /db_xref="EnsemblGenomes-Gn:BSU38520" /db_xref="EnsemblGenomes-Tr:CAB15878" /db_xref="GOA:P39579" /db_xref="InterPro:IPR003230" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR036736" /db_xref="PDB:4BPF" /db_xref="PDB:4BPG" /db_xref="PDB:4BPH" /db_xref="SubtiList:BG10549" /db_xref="UniProtKB/Swiss-Prot:P39579" /translation="MDFKQEVLDVLAEVCQDDIVKENPDIEIFEEGLLDSFGTVELLL AIENRFDILVPITEFDRDVWNTPNNIVNQLSELK*" /label="dltC CDS" gene 3455872..3456108 /gene="dltC" /locus_tag="BSU_38520" /old_locus_tag="BSU38520" /label="dltC gene" CDS 3456108..3457286 /gene="dltD" /locus_tag="BSU_38530" /old_locus_tag="BSU38530" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222605, 12028417, 14665680, 17263852, 17600057, 23858088; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative D-alanine from undecaprenylphosphate tothe polyglycerolphosphate chain for lipoteichoic acid andwall teichoic acid synthesis" /protein_id="NP_391732.1" /db_xref="EnsemblGenomes-Gn:BSU38530" /db_xref="EnsemblGenomes-Tr:CAB15879" /db_xref="GOA:P39578" /db_xref="InterPro:IPR006998" /db_xref="InterPro:IPR023896" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG10548" /db_xref="UniProtKB/Swiss-Prot:P39578" /translation="MKKRFFGPIILAFILFAGAIAIPSSWLTGFITDKRVKESATALN PSMFQGLYLQDQMLKDPTYLPIYGSSELSRLDEFHPSNYFQVNNEGFTPYLVGKGGSQ SLIHSLNFAAHMDQLKGKKIVFIVSPQWFIKRGSDEQHFAPNYSALQGLDLAFNDQID PEIKKKMMKRMLRFKAVQNDAILSELYKAMVNGQTWKVNALKPAAKVYYSMLEKKDLY YSTTESSGPKRYISQSVKDKSWSELNKLADQSGKRHSGSNDFHIDNPVYKKLKPKVPK LKGKNKGRSYAVSPEYGDFEMMLDILKDAGAEPMFVTIPVNGKWYDYTGFPKKGRTDY YKKVNKQIRAKGFQVADFSGHEYDPYFMKDTIHIGWKGWVYVDKAIDEFYKTGKVTSS *" /label="dltD CDS" gene 3456108..3457286 /gene="dltD" /locus_tag="BSU_38530" /old_locus_tag="BSU38530" /label="dltD gene" S_feature 3457287..3457376 /Source="Nicolas_S_feature" /locus_tag="new_3956402_3956491" /HighExp="Paraq, H2O2, Oxctl, LBGexp, Lbexp, dia0, C30, Cold, G150, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.998" /label="S1480" CDS 3457377..3458135 /gene="dltE" /locus_tag="BSU_38540" /old_locus_tag="BSU38540" /EC_number="1.-.-.-" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7797557, 14665680; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391733.2" /db_xref="EnsemblGenomes-Gn:BSU38540" /db_xref="EnsemblGenomes-Tr:CAB15880" /db_xref="GOA:P39577" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10547" /db_xref="UniProtKB/Swiss-Prot:P39577" /translation="MKMTNNTVLITGGSAGIGLELAKRLLELGNEVIICGRSEARLAE AKQQLPNIHTKQCDVADRSQREALYEWALKEYPNLNVLVNNAGIQKEIDFKKGTEELF VDGDEIELNFQAPVHLSALFTPHLMKQPEAAIVQVTSGLAFNPLAVYPVYCATKAALH SFSLTLRHQLRDTSVEVIEMAPPMVDTGLNQKSRDKQGLTYRGISSEEYVQYFLDGLK EGKQEITNERVEGLRDATRADYDRLFEQMNTQEN*" /label="dltE CDS" gene 3457377..3458135 /gene="dltE" /locus_tag="BSU_38540" /old_locus_tag="BSU38540" /label="dltE gene" downshifts 3458103 /Source="Nicolas_upshifts" /id="D1997" /incds=0 /nref=48 /ntot=172 /MaxReadThrough="5.94016" /MaxDrop="4.72547" /score="22.6844301" /energy="-13.7" /TU="U3035" /idTUdmin="U3035" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" S_feature complement(3458137..3459364) /Source="Nicolas_S_feature" /locus_tag="new_3957252_3958479_c" /HighExp="T0.30H, T1.0H, T1.30H, C30, B60, T2.0H, C90, Gly, T2.30H, S8" /AntisenseName="ilvK" /AntisenseCor="-0.12928749136401099" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1481" promotor_-35 3458183..3458190 /Source="Nicolas_upshift_promotors" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3458204..3458223 /Source="Nicolas_upshift_promotors" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3458217 /Source="Nicolas_upshifts" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="upshifts" CDS 3458276..3459367 /gene="ilvK" /locus_tag="BSU_38550" /old_locus_tag="BSU38550" /EC_number="2.6.1.42" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 17611193, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 17611193, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain amino acid aminotransferase" /protein_id="NP_391734.2" /db_xref="EnsemblGenomes-Gn:BSU38550" /db_xref="EnsemblGenomes-Tr:CAB15881" /db_xref="GOA:P39576" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005786" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR033939" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG10546" /db_xref="UniProtKB/Swiss-Prot:P39576" /translation="MTKQTIRVELTSTKKPKPDPNQLSFGRVFTDHMFVMDYAADKGW YDPRIIPYQPLSMDPAAMVYHYGQTVFEGLKAYVSEDDHVLLFRPEKNMERLNQSNDR LCIPQIDEEQVLEGLKQLVAIDKDWIPNAEGTSLYIRPFIIATEPFLGVAASHTYKLL IILSPVGSYYKEGIKPVKIAVESEFVRAVKGGTGNAKTAGNYASSLKAQQVAEEKGFS QVLWLDGIEKKYIEEVGSMNIFFKINGEIVTPMLNGSILEGITRNSVIALLKHWGLQV SERKIAIDEVIQAHKDGILEEAFGTGTAAVISPVGELIWQDETLSINNGETGEIAKKL YDTITGIQKGAVADEFGWTTEVAALTESK*" /label="ilvK CDS" gene 3458276..3459367 /gene="ilvK" /locus_tag="BSU_38550" /old_locus_tag="BSU38550" /label="ilvK gene" downshifts 3459269 /Source="Nicolas_upshifts" /id="D1998" /incds=1 /nref=10 /ntot=90 /MaxReadThrough="6.0829" /MaxDrop="3.1965" /score="32.8755878" /energy="-13.6" /TU="U3035,U3037" /idTUdmin="U3035" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts 3459357 /Source="Nicolas_upshifts" /id="D1999" /incds=0 /nref=157 /ntot=264 /MaxReadThrough="2.21106" /MaxDrop="6.83094" /score="32.8755878" /energy="-13.6" /TU="NA" /idTUdmin="U3035" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3459401..3460729) /gene="licH" /locus_tag="BSU_38560" /old_locus_tag="BSU38560" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8990303, 10438772, 22720735, 23874669, 24673833; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-beta-glucosidase" /protein_id="NP_391735.1" /db_xref="EnsemblGenomes-Gn:BSU38560" /db_xref="EnsemblGenomes-Tr:CAB15882" /db_xref="GOA:P46320" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11350" /db_xref="UniProtKB/Swiss-Prot:P46320" /translation="MTKGLKIVTIGGGSSYTPELVEGFIKRYDELPVRELWLVDIPEG EEKLNIVGTLAKRMVEKAGVPIDIHLTLDRRKALKDADFVTTQFRVGLLQARAKDERI PLKYGVIGQETNGPGGLFKGLRTIPVILEIAKDIEELCPNAWLVNFTNPAGMVTEALL RYSNLKKVVGLCNVPIGIKMGVAKALDVDVDRVEVQFAGLNHMVFGLDVFLDGVSVKE QVIEAMGDPKNAMTMKNISGAEWEPDFLKALNVIPCGYHRYYFKTKEMLEHELEASQT EGTRAEVVQKVEKELFELYKDPNLAIKPPQLEKRGGAYYSDAACNLISSIYNDKHDIQ PVNTINNGAIASIPDDSAVEVNCVMTKTGPKPIAVGDLPVSVRGLVQQIKSFERVAAE AAVTGDYQTALLAMTINPLVPSDTVAKQILDEMLEAHKAYLPQFFNKIEA*" /label="licH CDS" gene complement(3459401..3460729) /gene="licH" /locus_tag="BSU_38560" /old_locus_tag="BSU38560" /label="licH gene" downshifts complement(3459409) /Source="Nicolas_upshifts" /id="D2000" /incds=0 /nref=12 /ntot=98 /MaxReadThrough="4.92442" /MaxDrop="6.75565" /score="45.1562234" /energy="-15.7" /TU="U3038" /idTUdmin="U3038" /TUdmin="-152" /isTUend="FALSE" /label="downshifts" CDS complement(3460726..3461058) /gene="licA" /locus_tag="BSU_38570" /old_locus_tag="BSU38570" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIA component" /protein_id="NP_391736.1" /db_xref="EnsemblGenomes-Gn:BSU38570" /db_xref="EnsemblGenomes-Tr:CAB15883" /db_xref="GOA:P46319" /db_xref="InterPro:IPR003188" /db_xref="InterPro:IPR036542" /db_xref="SubtiList:BG11349" /db_xref="UniProtKB/Swiss-Prot:P46319" /translation="MNEEMEQIIFQIILHGGNGRSSAMEAIAAAKSGDAEEARKKLQD AAEELSKAHHYQTELIQNEAGGEKTEMTLLMVHAQDHLMNAMTVKDMAAEIIELYEKI TEQRGASI*" /label="licA CDS" gene complement(3460726..3461058) /gene="licA" /locus_tag="BSU_38570" /old_locus_tag="BSU38570" /label="licA gene" CDS complement(3461077..3462435) /gene="licC" /locus_tag="BSU_38580" /old_locus_tag="BSU38580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIC component" /protein_id="NP_391737.1" /db_xref="EnsemblGenomes-Gn:BSU38580" /db_xref="EnsemblGenomes-Tr:CAB15884" /db_xref="GOA:P46317" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004501" /db_xref="InterPro:IPR004796" /db_xref="SubtiList:BG11348" /db_xref="UniProtKB/Swiss-Prot:P46317" /translation="MNKVNQILEEKVMPIAGRIAGQRHLQALRDGIILTMPLIIIGSF FLIIGNLPIPGYAEFMAKTFGSSWSEKLAYPVDATFEIMGLVAAFGIAYRLAEKYGVD ALSAGAISLAAFLLATPYQVPFMPDGATKEIMVGGGIPLSLMGSKGLFVAMIIAMVST EIYRLIIQRNLVFKMPDGVPPAVSKSFVALIPGFAVIFLIWAARLIVEATPFESLHNI VSVLLGTPLSILGGSLGGSLVAEAVKMLLWACGLHGANIVGGVMAPIWYGAMDANRIA FQAGEELPKIFTQQFFDIWVNIGGSGATLALVVTMFLRARSKQMKQLGKLAVGPAIFN INEPIIFGMPIVMNPMLLLPFIITPLVTVTLTYIGMSTGLVAKPAGIAVPWTMPPIFS GYLATGGKVSGAVMQAINIAVSFVVYYPFFRMWDKQKLKEENDLELVQTPAATDDKEA AL*" /label="licC CDS" gene complement(3461077..3462435) /gene="licC" /locus_tag="BSU_38580" /old_locus_tag="BSU38580" /label="licC gene" CDS complement(3462451..3462759) /gene="licB" /locus_tag="BSU_38590" /old_locus_tag="BSU38590" /EC_number="2.7.1.-" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 23874669" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 23874669; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIB component" /protein_id="NP_391738.1" /db_xref="EnsemblGenomes-Gn:BSU38590" /db_xref="EnsemblGenomes-Tr:CAB15885" /db_xref="GOA:P46318" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR013012" /db_xref="InterPro:IPR036095" /db_xref="SubtiList:BG11347" /db_xref="UniProtKB/Swiss-Prot:P46318" /translation="MNILLVCAAGMSTSLLVSKMEKSAQEQGKDYTIWAVSGDSVQNH IDKADVLLLGPQVRYMLPQLKKLGESKGVPVDVINTVHYGTCNGAEVLKSAEQLGHVS *" /label="licB CDS" gene complement(3462451..3462759) /gene="licB" /locus_tag="BSU_38590" /old_locus_tag="BSU38590" /label="licB gene" promotor_-10 complement(3462804..3462823) /Source="Nicolas_upshift_promotors" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3462820) /Source="Nicolas_upshifts" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3462837..3462843) /Source="Nicolas_upshift_promotors" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3462888) /Source="Nicolas_upshifts" /id="D2001" /incds=0 /nref=3 /ntot=74 /MaxReadThrough="3.19679" /MaxDrop="2.70222" /score="27.6067633" /energy="-11.1" /TU="U3040" /idTUdmin="U3040" /TUdmin="-45" /isTUend="FALSE" /label="downshifts" CDS complement(3462888..3464813) /gene="licR" /locus_tag="BSU_38600" /old_locus_tag="BSU38600" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8990303, 9353933, 10438772" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 9353933, 10438772; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the lichenan operon" /protein_id="NP_391739.1" /db_xref="EnsemblGenomes-Gn:BSU38600" /db_xref="EnsemblGenomes-Tr:CAB15886" /db_xref="GOA:P46321" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG11346" /db_xref="UniProtKB/Swiss-Prot:P46321" /translation="MLHGRLRDILRLLMAAEAPVTSSFFAAQLNVTTRTVRNDIKELQ GVLSGHGAFVQSVRGSGYKLRIDDEQVFRTLLQDEFQQKKGLPVLPEERMAYLMKRLL LADHYLKLDELAEELFISKSTLQTDLKEVKKRLLPYRIVMETRPNYGFKLRGDEVQMR YCMAEYIVDERETEIDVLNEKADILPKEEIEIIRSAILKKMKNDRIPLSNMGLNNLII HIAIACKRIRTENYVSLFPKDMDHILHQKEYQAAEAIVKELESKLSVTFPKDETAYIT MHLLGTKRMTQSQCGEDTFSIEEETDQLTLAMIKAVDRELKLGILHDKELKIGLALHM KPAISRNRYGMNLRNPMLAAIKEHYPLAFEAGIIAGIVIKEQTGIEIHENEIGYLALH FGAAIERKKTESPPKRCIIVCASGAGSAQLLREKLRSHFGKRLDILGTAEYYSLDQMS YESIDFVISTIPIKKELPVPVLKVNTILGGTDFTKIESILSDEKEKANRYLKKELVFF QEDLRSKEEVIQFLGQKVVECGFADEEIIDSIFEREDMSPTCFGNLVAIPHPLVPQTK TTFWAVCTLKKPIDWESQRVQFVCLLCVEKENKADLQSMYKLLGSILDDPAAMNQLIK CRSYQELSDVFDQKMLS*" /label="licR CDS" gene complement(3462888..3464813) /gene="licR" /locus_tag="BSU_38600" /old_locus_tag="BSU38600" /label="licR gene" promotor_-35 3463551..3463560 /Source="Nicolas_upshift_promotors" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3463574..3463593 /Source="Nicolas_upshift_promotors" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3463582 /Source="Nicolas_upshifts" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3464886..3464903) /Source="Nicolas_upshift_promotors" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="promotor_-10" upshifts complement(3464910) /Source="Nicolas_upshifts" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="upshifts" promotor_-35 complement(3464918..3464925) /Source="Nicolas_upshift_promotors" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="promotor_-35" CDS complement(3464976..3465134) /gene="yxzF" /locus_tag="BSU_38610" /old_locus_tag="BSU38610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391740.1" /db_xref="EnsemblGenomes-Gn:BSU38610" /db_xref="EnsemblGenomes-Tr:CAB15887" /db_xref="SubtiList:BG14169" /db_xref="UniProtKB/Swiss-Prot:O32283" /translation="MVEKKEGRIGALKKMIKTVIKWAPVIYPIVRKIMKDRKASKQKN MSASRTAG*" /label="yxzF CDS" gene complement(3464976..3465134) /gene="yxzF" /locus_tag="BSU_38610" /old_locus_tag="BSU38610" /label="yxzF gene" downshifts complement(3465003) /Source="Nicolas_upshifts" /id="D2002" /incds=0 /nref=75 /ntot=208 /MaxReadThrough="0.739420000000001" /MaxDrop="6.4099" /score="27.6067633" /energy="-11.1" /TU="NA" /idTUdmin="U3041" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(3465163..3465753) /gene="aag" /locus_tag="BSU_38620" /old_locus_tag="BSU38620" /EC_number="3.2.2.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14729667, 27698084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14729667, 27698084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-alkylated purines and hypoxanthine DNA glycosidase" /protein_id="NP_391741.1" /db_xref="EnsemblGenomes-Gn:BSU38620" /db_xref="EnsemblGenomes-Tr:CAB15888" /db_xref="GOA:P94378" /db_xref="InterPro:IPR003180" /db_xref="InterPro:IPR011034" /db_xref="InterPro:IPR036995" /db_xref="SubtiList:BG12555" /db_xref="UniProtKB/Swiss-Prot:P94378" /translation="MTREKNPLPITFYQKTALELAPSLLGCLLVKETDEGTASGYIVE TEAYMGAGDRAAHSFNNRRTKRTEIMFAEAGRVYTYVMHTHTLLNVVAAEEDVPQAVL IRAIEPHEGQLLMEERRPGRSPREWTNGPGKLTKALGVTMNDYGRWITEQPLYIESGY TPEAISTGPRIGIDNSGEARDYPWRFWVTGNRYVSR*" /label="aag CDS" gene complement(3465163..3465753) /gene="aag" /locus_tag="BSU_38620" /old_locus_tag="BSU38620" /label="aag gene" promotor_-10 complement(3465781..3465799) /Source="Nicolas_upshift_promotors" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3465792) /Source="Nicolas_upshifts" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3465813..3465819) /Source="Nicolas_upshift_promotors" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3465822..3465828 /Source="Nicolas_upshift_promotors" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3465844..3465862 /Source="Nicolas_upshift_promotors" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3465847 /Source="Nicolas_upshifts" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="upshifts" CDS 3465882..3467525 /gene="katX" /locus_tag="BSU_38630" /old_locus_tag="BSU38630" /EC_number="1.11.1.6" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9393707, 9555886, 10503549, 24123749" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9393707, 9555886, 10503549, 24123749; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="major catalase in spores" /protein_id="NP_391742.1" /db_xref="EnsemblGenomes-Gn:BSU38630" /db_xref="EnsemblGenomes-Tr:CAB15889" /db_xref="GOA:P94377" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024711" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG11945" /db_xref="UniProtKB/Swiss-Prot:P94377" /translation="MKDDHQNKQHQSNAQGSEEAFSHKTSGKNESEDTLTNRQGHPVT DNQNVRTVGNRGPTTLENYDFLEKISHFDRERIPERVVHARGAGAHGYFEAYGSFGDE PISTYTRAKLFQEKGKKTPAFVRFSTVNHGKHSPETLRDPRGFAVKLYTEDGNWDLVG NNLKIFFIRDPLKFPDLVHAFQPDPVTNIQDGERIFDFISQSPEATHMITFLFSPWGI PANYRQMQGSGVHAYKWVNEEGKAVLVKYHFEPKQGIRNLTQKEAEEIQGKNFNHATQ DLYDAIENGDYPEWEVYAQIMSDDEHPELDFDPLDPTKLWYKDDFPWKPIGKLVLNKN PENYHAEVEQASFGTGVLVDGLDFSDDKLLQGRTFAYSDTQRYRVGANYLQLPINSPK KHVATNQEGGQMQYRVDRAEGQNPHVNYEPSIMGGLKEAKQDGKDHTPHVEGDVKREA IDRTNNFGQAGETYRRFTEFERNELITNLVNTLSTCRKEIQDQMIENFTKADPDYGKR VAEGLKKVSENNSNGPIGTTETEQAAKQAEQESHPSDPY*" /label="katX CDS" gene 3465882..3467525 /gene="katX" /locus_tag="BSU_38630" /old_locus_tag="BSU38630" /label="katX gene" S_feature complement(3466019..3467568) /Source="Nicolas_S_feature" /locus_tag="new_3965134_3966683_c" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T2.30H, T3.0H, S8, T3.30H, S6, T0.0H" /AntisenseName="katX" /AntisenseCor="0.28909015498211399" /AntisenseRegPval="-5.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1482" downshifts 3467520 /Source="Nicolas_upshifts" /id="D2003" /incds=0 /nref=28 /ntot=49 /MaxReadThrough="0.942820000000001" /MaxDrop="5.69337" /score="45.0252072" /energy="-12.7" /TU="NA" /idTUdmin="U3042" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3467570..3467661) /Source="Nicolas_S_feature" /locus_tag="new_3966685_3966776_c" /HighExp="T0.30H, T1.30H, T1.0H, T2.0H, T2.30H, T3.30H, T4.0H, T3.0H, T0.0H, T5.0H" /AntisenseName="yxlH" /AntisenseCor="-4.8005444617814199E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1483" promotor_-35 3467572..3467578 /Source="Nicolas_upshift_promotors" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3467586 /Source="Nicolas_upshifts" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3467593..3467612 /Source="Nicolas_upshift_promotors" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(3467613) /Source="Nicolas_upshifts" /id="D2004" /incds=0 /nref=8 /ntot=42 /MaxReadThrough="3.81662" /MaxDrop="3.1285" /score="-7.60062702" /energy="-7.5" /TU="U3045" /idTUdmin="U3045" /TUdmin="-1557" /isTUend="FALSE" /label="downshifts" CDS 3467630..3468832 /gene="yxlH" /locus_tag="BSU_38640" /old_locus_tag="BSU38640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14769884, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391743.1" /db_xref="EnsemblGenomes-Gn:BSU38640" /db_xref="EnsemblGenomes-Tr:CAB15890" /db_xref="GOA:P94376" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12554" /db_xref="UniProtKB/Swiss-Prot:P94376" /translation="MELQQDLIPQKKTIGALDHAVFLCMVFCFWFSGYIYVPVFSLYL EDLHFSYGAIGIILGSYGVTQILLRFPLGLLSDILFSLRKQLLIAGFGFSVLSSLLFL MFDSFFFVLAARLFAGITASTWVMATILYAHYFNNGNASKAMGIMQFFTVMPQFASIV FCGLAAAHLGRQVPFWMALAASAAGLVICCFIQDPSAPPANRGTIRVNQYIKDTLRLP KLKLFTILSMTAHAVLFITVFGFTPLYMNQLGMGDAELLWVMSAFFLPHAAATLSFVF LRFTSRIAYSVMLISFAVTGVCLLYVPFLAALFTVCITHACIGLALGFVFPLLLSHVV EISSARLKMSVMGFYQSFYALGIFLGPLLAGKIAQLIGLAGVFYGAGSLAFAAFFVML AQKRNMIN*" /label="yxlH CDS" gene 3467630..3468832 /gene="yxlH" /locus_tag="BSU_38640" /old_locus_tag="BSU38640" /label="yxlH gene" S_feature complement(3467663..3468828) /Source="Nicolas_S_feature" /locus_tag="new_3966778_3967943_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T0.0H, T3.0H, T3.30H, T-0.40H, T4.0H" /AntisenseName="yxlH" /AntisenseCor="-4.5703316381945601E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1484" downshifts complement(3467706) /Source="Nicolas_upshifts" /id="D2005" /incds=1 /nref=3 /ntot=61 /MaxReadThrough="6.44992" /MaxDrop="2.92619" /score="-7.60062702" /energy="-7.5" /TU="U3045" /idTUdmin="U3045" /TUdmin="-1650" /isTUend="FALSE" /label="downshifts" CDS complement(3468829..3469605) /gene="yxlG" /locus_tag="BSU_38650" /old_locus_tag="BSU38650" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14769884, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC-transporter (permease)" /protein_id="NP_391744.2" /db_xref="EnsemblGenomes-Gn:BSU38650" /db_xref="EnsemblGenomes-Tr:CAB15891" /db_xref="GOA:P94375" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG12553" /db_xref="UniProtKB/Swiss-Prot:P94375" /translation="MKVMMALLQKEWLEGWKSGKLIWLPIAMMIVGLTQPLTIYYMPE IIAHGGNLPDGMKISFTMPSGSEVMVSTLSQFNTLGMALVIFSVMGSVANERNQGVTA LIMSRPVTAAHYIVSKWLIQSVIGIMSFAAGYGLAYYYVRLLFEDASFSRFAASLGLY ALWVIFIVTAGLAGSTIFRSVGAAAACGIGLTAAVSFAVSLFPDGAKWLPAEICKQAE HILLHGERADFFGWSLTFSILCIMLLAVFSVWRFRRYESY*" /label="yxlG CDS" gene complement(3468829..3469605) /gene="yxlG" /locus_tag="BSU_38650" /old_locus_tag="BSU38650" /label="yxlG gene" CDS complement(3469602..3470489) /gene="yxlF" /locus_tag="BSU_38660" /old_locus_tag="BSU38660" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12897008, 14769884, 14993308; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter component (ATP-binding protein)" /protein_id="NP_391745.1" /db_xref="EnsemblGenomes-Gn:BSU38660" /db_xref="EnsemblGenomes-Tr:CAB15892" /db_xref="GOA:P94374" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR025302" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12552" /db_xref="UniProtKB/Swiss-Prot:P94374" /translation="MLSIESLCKSYRHHEAVKNVSFHVNENECVALLGPNGAGKTTTL QMLAGLLSPTSGTIKLLGEKKLDRRLIGYLPQYPAFYSWMTANEFLTFAGRLSGLSKR KCQEKIGEMLEFVGLHEAAHKRIGGYSGGMKQRLGLAQALLHKPKFLILDEPVSALDP TGRFEVLDMMRELKKHMAVLFSTHVLHDAEQVCDQVVIMKNGEISWKGELQELKQQQQ TNVFTLSVKEKLEGWLEEKPYVSAIVYKNPSQAVFELPDIHAGRSLLSDCIRKGLTVT RFEQKTESLEDVYLKVVHA*" /label="yxlF CDS" gene complement(3469602..3470489) /gene="yxlF" /locus_tag="BSU_38660" /old_locus_tag="BSU38660" /label="yxlF gene" CDS complement(3470496..3470684) /gene="yxlE" /locus_tag="BSU_38670" /old_locus_tag="BSU38670" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of sigma-Y activity" /protein_id="NP_391746.1" /db_xref="EnsemblGenomes-Gn:BSU38670" /db_xref="EnsemblGenomes-Tr:CAB15893" /db_xref="GOA:P94373" /db_xref="InterPro:IPR027379" /db_xref="SubtiList:BG12551" /db_xref="UniProtKB/Swiss-Prot:P94373" /translation="MNISWEMILPLIVLQLALAVFALISCIKEERTNGPKWMWAAIIV CINIIGPILFFTVGRKQR*" /label="yxlE CDS" gene complement(3470496..3470684) /gene="yxlE" /locus_tag="BSU_38670" /old_locus_tag="BSU38670" /label="yxlE gene" CDS complement(3470681..3470887) /gene="yxlD" /locus_tag="BSU_38680" /old_locus_tag="BSU38680" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative sigma-Y antisigma factor component" /protein_id="NP_391747.1" /db_xref="EnsemblGenomes-Gn:BSU38680" /db_xref="EnsemblGenomes-Tr:CAB15894" /db_xref="GOA:P94372" /db_xref="SubtiList:BG12550" /db_xref="UniProtKB/Swiss-Prot:P94372" /translation="MTQTEIIITVAACLIVLAQGIFLFIDAKKRNHMAWVWGIVGLIQ APMPLICYYFFVIRPDRKKRGIKQ*" /label="yxlD CDS" gene complement(3470681..3470887) /gene="yxlD" /locus_tag="BSU_38680" /old_locus_tag="BSU38680" /label="yxlD gene" CDS complement(3470884..3471204) /gene="yxlC" /locus_tag="BSU_38690" /old_locus_tag="BSU38690" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="sigma-Y antisigma factor" /protein_id="NP_391748.1" /db_xref="EnsemblGenomes-Gn:BSU38690" /db_xref="EnsemblGenomes-Tr:CAB15895" /db_xref="GOA:P94371" /db_xref="InterPro:IPR035238" /db_xref="SubtiList:BG12549" /db_xref="UniProtKB/Swiss-Prot:P94371" /translation="MNKEKLSDHLKSEWKKIDQTANPSIPNQKELLHQLSQMKAEYRK KLLQEIILFVFCALMVVSAAILAFTQAPAVFIVLQVCVLAVLPILIAAEKKRHLGECE VKRG*" /label="yxlC CDS" gene complement(3470884..3471204) /gene="yxlC" /locus_tag="BSU_38690" /old_locus_tag="BSU38690" /label="yxlC gene" promotor_-35 3471017..3471026 /Source="Nicolas_upshift_promotors" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3471039..3471058 /Source="Nicolas_upshift_promotors" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3471041 /Source="Nicolas_upshifts" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3471197..3471733) /gene="sigY" /locus_tag="BSU_38700" /old_locus_tag="BSU38700" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF (extracytoplasmic function)-type sigma factor (sigma-Y)" /protein_id="NP_391749.1" /db_xref="EnsemblGenomes-Gn:BSU38700" /db_xref="EnsemblGenomes-Tr:CAB15896" /db_xref="GOA:P94370" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11975" /db_xref="UniProtKB/Swiss-Prot:P94370" /translation="MDTQEEQRLIQQAKEGNDEAFTALFHYHYSFLYKYLLKLSLHPD LSEELVQETFLKGYIHLRSFQGRSKFSTWLISIASRLYLDHQKKRKREWKRNQTVTEE TIRKIKWDVSAKGAEWSETLDLFSKLDPKLRTPVLLRHYYGYTYAEIGVMLQIKEGTV KSRVHKGLQQIRKEWDDE*" /label="sigY CDS" gene complement(3471197..3471733) /gene="sigY" /locus_tag="BSU_38700" /old_locus_tag="BSU38700" /label="sigY gene" upshifts complement(3471761) /Source="Nicolas_upshifts" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3471762..3471777) /Source="Nicolas_upshift_promotors" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3471789..3471798) /Source="Nicolas_upshift_promotors" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3471864..3471871 /Source="Nicolas_upshift_promotors" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3471885..3471904 /Source="Nicolas_upshift_promotors" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3471894 /Source="Nicolas_upshifts" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="upshifts" CDS 3471945..3473318 /gene="yxlA" /locus_tag="BSU_38710" /old_locus_tag="BSU38710" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2191181, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative purine-cytosine (pyridoxine) permease" /protein_id="NP_391750.1" /db_xref="EnsemblGenomes-Gn:BSU38710" /db_xref="EnsemblGenomes-Tr:CAB15897" /db_xref="GOA:P94369" /db_xref="InterPro:IPR001248" /db_xref="InterPro:IPR026030" /db_xref="SubtiList:BG12548" /db_xref="UniProtKB/Swiss-Prot:P94369" /translation="MKVERRTIEYIPNEERHGKAKDLFPVWFGANMHITTLVTGTIPV AMGLNLFWSVAAIICGTLIGAIFMASHSAQGPQLGIPQMIQSRAQFGVIGAILPLFLV MFIYLGFFASSTILAAGTLSSFVPIPGSWSIIGLSAVCFLLTIFGHDLIHKMQKILSW TSFAVFFAATILIFQLPIPAGSWIPGAIDLPIFLVAVSAVATWQLAYAPYVADYSRYL PVKTPASKTFWYSYAGTSVSSIWMMLLGALLTTSLPDFTANSGSQIVQLFGPFSFIML IIVLFGQMAINVFNLYGAFMSTTTTLEPFLKLKVTPKVRIIMILGVTLVGTVLSLLGQ SNFMELFLNFIFFISYFLIPWTAINLVDYYFVRHGKYQVKAMFDVNGPYGKVNWITTI AFVLSILLEIPFINTSFYIGPLAKMFGGGDIAWIIGLAVPSVLYYVLMKPRLKKRAGY QEKLSSL*" /label="yxlA CDS" gene 3471945..3473318 /gene="yxlA" /locus_tag="BSU_38710" /old_locus_tag="BSU38710" /label="yxlA gene" S_feature complement(3472225..3472767) /Source="Nicolas_S_feature" /locus_tag="new_3971340_3971882_c" /HighExp="Etha, LBGstat, T1.0H, T0.30H, Diami, T1.30H, dia15, G150, G135, G180" /AntisenseName="yxlA" /AntisenseCor="-8.6586358833710395E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1485" promotor_-10 complement(3472755..3472774) /Source="Nicolas_upshift_promotors" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3472767) /Source="Nicolas_upshifts" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3472789..3472796) /Source="Nicolas_upshift_promotors" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3473153 /Source="Nicolas_upshifts" /id="D2006" /incds=1 /nref=30 /ntot=136 /MaxReadThrough="1.87017" /MaxDrop="3.59478" /score="22.3054019" /energy="-12.9" /TU="NA" /idTUdmin="U3046" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3473333..3474163) /gene="nnrA" /locus_tag="BSU_38720" /old_locus_tag="BSU38720" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12457846, 21994945, 22940582, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12457846, 21994945, 22940582, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD(P)H dehydratase" /protein_id="NP_391751.1" /db_xref="EnsemblGenomes-Gn:BSU38720" /db_xref="EnsemblGenomes-Tr:CAB15898" /db_xref="GOA:P94368" /db_xref="InterPro:IPR000631" /db_xref="InterPro:IPR017953" /db_xref="InterPro:IPR029056" /db_xref="PDB:1KYH" /db_xref="PDB:3RPH" /db_xref="PDB:3RPZ" /db_xref="PDB:3RQ2" /db_xref="PDB:3RQ5" /db_xref="PDB:3RQ6" /db_xref="PDB:3RQ8" /db_xref="PDB:3RQH" /db_xref="PDB:3RQQ" /db_xref="PDB:3RQX" /db_xref="SubtiList:BG12547" /db_xref="UniProtKB/Swiss-Prot:P94368" /translation="MNVPFWTEEHVRATLPERDAESHKGTYGTALLLAGSDDMPGAAL LAGLGAMRSGLGKLVIGTSENVIPLIVPVLPEATYWRDGWKKAADAQLEETYRAIAIG PGLPQTESVQQAVDHVLTADCPVILDAGALAKRTYPKREGPVILTPHPGEFFRMTGVP VNELQKKRAEYAKEWAAQLQTVIVLKGNQTVIAFPDGDCWLNPTGNGALAKGGTGDTL TGMILGMLCCHEDPKHAVLNAVYLHGACAELWTDEHSAHTLLAHELSDILPRVWKRFE *" /label="nnrA CDS" gene complement(3473333..3474163) /gene="nnrA" /locus_tag="BSU_38720" /old_locus_tag="BSU38720" /label="nnrA gene" downshifts complement(3473339) /Source="Nicolas_upshifts" /id="D2007" /incds=0 /nref=3 /ntot=52 /MaxReadThrough="3.50755" /MaxDrop="3.84264" /score="7.61210868" /energy="-12.9" /TU="U3048" /idTUdmin="U3051" /TUdmin=792 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3474182..3474200) /Source="Nicolas_upshift_promotors" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3474197) /Source="Nicolas_upshifts" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3474215..3474221) /Source="Nicolas_upshift_promotors" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3474241) /Source="Nicolas_upshifts" /id="U3049" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.973026973026973" /psig="0.98101898101898" /xcortree=2119 /SigmaFactorBS="cggcaaacgaacgatatcgccgcctgtatcaccttgatgTTC CTGTAAAATAAAAGACAgccctaaaaggctgtcttttttgtttgaaaaagaaaaggga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3474243..3474262) /Source="Nicolas_upshift_promotors" /id="U3049" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.973026973026973" /psig="0.98101898101898" /xcortree=2119 /SigmaFactorBS="cggcaaacgaacgatatcgccgcctgtatcaccttgatgTTC CTGTAAAATAAAAGACAgccctaaaaggctgtcttttttgtttgaaaaagaaaaggga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3474249..3475976) /gene="cydD" /locus_tag="BSU_38730" /old_locus_tag="BSU38730" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9852001, 10551842, 15231791, 16040611, 26517902, 26699904; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC membrane transporter (ATP-binding protein) required for cytochrome bb' function (reductant efflux pump)" /protein_id="NP_391752.1" /db_xref="EnsemblGenomes-Gn:BSU38730" /db_xref="EnsemblGenomes-Tr:CAB15899" /db_xref="GOA:P94367" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR014223" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11928" /db_xref="UniProtKB/Swiss-Prot:P94367" /translation="MKKEEWILPYIKQNARLFVLVIFLGAVTIFSAAFLMFTSGFLIS KAATRPENILLIYVPIVAVRTFGIARSVSRYVERLVGHHIILKIVSDMRVRLYNMLEP GALMLRSRFRTGDMLGILSEDIEHLQDAFLKTIFPAISALLLYAVSVIALGFFSWPFA ILLALYLFVLVVLFPVVSLLVTRAKNAKLKSGRNVLYSRLTDAVMGVSDWMFSGRRHA FIDAYEKEERDWFELERKKQRFTRWRDFAAQCLVAGLILLMLFWTAGQQADGELAKTM IAAFVLVVFPLTEAFLPLSDALGEVPGYQDSIRRMNNVAPQPEASQTESGDQILDLQD VTLAFRDVTFSYDNSSQVLHNFSFTLRQGEKMALLGRSGSGKSTSLALIEGALKPDSG SVTLNGVETALLKDQIADAVAVLNQKPHLFDTSILNNIRLGNGEASDEDVRRAAKQVK LHDYIESLPDGYHTSVQETGIRFSGGERQRIALARILLQDTPIIILDEPTVGLDPITE RELMETVFEVLKGKTILWITHHLAGVEAADKIVFLENGKTEMEGTHEELLAANERYRR LYHLDVPVK*" /label="cydD CDS" gene complement(3474249..3475976) /gene="cydD" /locus_tag="BSU_38730" /old_locus_tag="BSU38730" /label="cydD gene" downshifts complement(3474348) /Source="Nicolas_upshifts" /id="D2008" /incds=1 /nref=7 /ntot=46 /MaxReadThrough="5.39758" /MaxDrop="3.66431" /score="25.0271963" /energy="-10.6" /TU="U3051" /idTUdmin="U3051" /TUdmin="-217" /isTUend="FALSE" /label="downshifts" CDS complement(3475973..3477676) /gene="cydC" /locus_tag="BSU_38740" /old_locus_tag="BSU38740" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9852001, 10551842, 15231791, 16040611, 26517902, 26699904; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC membrane transporter (ATP-binding protein) required for cytochrome bb' function (reductant efflux pump)" /protein_id="NP_391753.1" /db_xref="EnsemblGenomes-Gn:BSU38740" /db_xref="EnsemblGenomes-Tr:CAB15900" /db_xref="GOA:P94366" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR014216" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11927" /db_xref="UniProtKB/Swiss-Prot:P94366" /translation="MGKDLFRYKGMKRILTLITCLTLIQTAAIIMQAEWLSEAVTGLF NGKGITSLLPVIGFFLIAFIARHGMTVARQKIVYQYAARTGADLRKSFLDQLFRLGPR FAKKEGTGQMVTLAMEGISQFRRYLELFLPKMVSMAIVPAAVVIYVFFQDRTSAIILV AAMPILIIFMILLGLVAQRKADRQWKSYQRLSNHFVDSLRGLETLRFLGLSKSHSKNI FYVSERYRKATMSTLRVAFLSSFALDFFTMLSVATVAVFLGLRLIDGDILLGPALTAL ILAPEYFLPVREVGNDYHATLNGQEAGKTIQEILSQPGFKEETPLQLEAWSDQDELKL SGVSVGRSVSDIHLSFKGKKKIGIIGASGAGKSTLIDILGGFLEPDGGMIEVNGTSRS HLQDGSWQKNLLYIPQHPYIFDDTLGNNIRFYHPSASAEDTTRAAASAGLTELVNNLP DGLEGRIGEGGRALSGGQAQRVALARAFLGNRPILLLDEPTAHLDIETEYEIKETMLD LFEDKLVFLATHRLHWMLDMDEIIVLDGGRVAEIGTHNELLEKNGVYTKLVKAQLGER A*" /label="cydC CDS" gene complement(3475973..3477676) /gene="cydC" /locus_tag="BSU_38740" /old_locus_tag="BSU38740" /label="cydC gene" CDS complement(3477676..3478692) /gene="cydB" /locus_tag="BSU_38750" /old_locus_tag="BSU38750" /EC_number="1.10.3.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9852001, 10551842, 15231791, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852001, 10551842, 15231791, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome bb' ubiquinol oxidase (subunit II)" /protein_id="NP_391754.1" /db_xref="EnsemblGenomes-Gn:BSU38750" /db_xref="EnsemblGenomes-Tr:CAB15901" /db_xref="GOA:P94365" /db_xref="InterPro:IPR003317" /db_xref="SubtiList:BG11926" /db_xref="UniProtKB/Swiss-Prot:P94365" /translation="MASLHDLWFILVAVLFVGFFFLEGFDFGVGMATRFLGHNELERR VLINTIGPFWDANEVWLLTGAGAIFAAFPNWYATMLSGYYIPFVIVLLALMGRGVAFE FRGKVDHLKWVKVWDWVVFFGSLIPPFVLGVLFTTLFRGMPIDADMNIHAHVSDYINV YSILGGVTVTLLCFQHGLMFITLRTIGDLQNRARKMAQKIMGVVFVAVLAFAALSAYQ TDMFTRRGEITIPLAVLIVICFMLAAVFIRKKKDGWTFGMTGAGLALTVGMIFISLFP RVMVSSLHSAYDLTVANASSGDYSLKVMSIAALTLLPFVIGSQIWSYYVFRKRVSHKE PMTY*" /label="cydB CDS" gene complement(3477676..3478692) /gene="cydB" /locus_tag="BSU_38750" /old_locus_tag="BSU38750" /label="cydB gene" promotor_-10 complement(3478566..3478584) /Source="Nicolas_upshift_promotors" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3478575) /Source="Nicolas_upshifts" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3478600..3478605) /Source="Nicolas_upshift_promotors" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3478676..3480082) /gene="cydA" /locus_tag="BSU_38760" /old_locus_tag="BSU38760" /EC_number="1.10.3.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9852001, 10551842, 15231791, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852001, 10551842, 15231791, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome bb' ubiquinol oxidase (subunit I)" /protein_id="NP_391755.1" /db_xref="EnsemblGenomes-Gn:BSU38760" /db_xref="EnsemblGenomes-Tr:CAB15902" /db_xref="GOA:P94364" /db_xref="InterPro:IPR002585" /db_xref="SubtiList:BG11925" /db_xref="UniProtKB/Swiss-Prot:P94364" /translation="MSELVLARIQFASTTLFHFLFVPMSIGLVFMVALMETLYLVKKN ELYLKMAKFWGHLFLINFAVGVVTGILQEFQFGLNWSDYSRFVGDVFGAPLAIEALLA FFMESIFIGLWIFGWDRLPKKIHALCIWLVSFGTIMSSFWILTANSFMQEPVGFTIKN GRAEMNDFGALITNPQLWVEFPHVIFGALATGAFFIAGVSAFKLLKKKEVPFFKQSFK LAMIVGLCAGLGVGLSGHMQAEHLMESQPMKMAASEGLWEDSGDPAAWTAFATIDTKN EKSSNEIKVPYALSYLAYQKFSGSVKGMKTLQAEYEKIYGKGDYIPPVKTTFWSFRIM VGAGVVMILAALGGLWLNRRKKLENSKWYLRIMIALISFPFLANSAGWIMTEIGRQPW TVMGLMTTAQSVSPNVTAGSLLFSIIAFGVMYMILGALLVFLFIREIKKGAEHDNHHD VPVSTDPFSQEVYHGISS*" /label="cydA CDS" gene complement(3478676..3480082) /gene="cydA" /locus_tag="BSU_38760" /old_locus_tag="BSU38760" /label="cydA gene" S_feature complement(3480083..3480291) /Source="Nicolas_S_feature" /locus_tag="new_3979198_3979406_c" /HighExp="M0t45, ferm, UNK1, Gly, Lbexp, Lbstat, dia0, nit, M/G, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1486" promotor_-10 complement(3480274..3480293) /Source="Nicolas_upshift_promotors" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3480291) /Source="Nicolas_upshifts" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3480293..3480401) /Source="Nicolas_S_feature" /locus_tag="new_3979408_3979516_c" /HighExp="LPhT, LBGtran, ferm, LBGstat, M0t45, dia0, Etha, dia5, Lbexp, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1487" promotor_-35 complement(3480307..3480312) /Source="Nicolas_upshift_promotors" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3480398..3480417) /Source="Nicolas_upshift_promotors" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="promotor_-10" upshifts complement(3480413) /Source="Nicolas_upshifts" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="upshifts" promotor_-35 complement(3480431..3480438) /Source="Nicolas_upshift_promotors" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="promotor_-35" promotor_-35 3480559..3480566 /Source="Nicolas_upshift_promotors" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3480576 /Source="Nicolas_upshifts" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3480581..3480599 /Source="Nicolas_upshift_promotors" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3480638..3481990 /gene="cimH" /locus_tag="BSU_38770" /old_locus_tag="BSU38770" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11566984, 12525174, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11566984, 12525174, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="citrate/malate/H+ symporter" /protein_id="NP_391756.1" /db_xref="EnsemblGenomes-Gn:BSU38770" /db_xref="EnsemblGenomes-Tr:CAB15903" /db_xref="GOA:P94363" /db_xref="InterPro:IPR004679" /db_xref="InterPro:IPR018025" /db_xref="SubtiList:BG12546" /db_xref="UniProtKB/Swiss-Prot:P94363" /translation="MGELQTHMQLQTDTIHEGVRKENWFAKAMNIKVGIIPLPVYALL FILITVFVMHHDVKSDILTSIAVMAFFGFTFAQIGKSIPIVRSIGGPAILATFIPSAV VYYHLLPNDIVKSTTEFTENSNFLYLFIAGIVVGSILGMKRETLVKAFMKIFIPLIVG SVTAAIVGLAVGTLLGLGFQHTLLYIVIPIMAGGVGEGAIPLSIGYSDIMPISQGEAF ALVLPSIMLGSLCAIILAGLLNRIGKKKPEWTGNGKVDRSEEESPALEESQSGQQMFN LSLFASGGILAVSLYLVGMLAHDFFGFPAPVAMLLLAVLIKLFRLVPASIENGAFGVS RFFSTAVTYPLLFAIGVSMTPWDKLVAAFNLSNIITILSVVVTMMAVGFFTGKWLNMY PIETAIINACHSGQGGTGDVAILSAAERLELMPFAQVSTRIGGAITVSLTLLLLHQFY *" /label="cimH CDS" gene 3480638..3481990 /gene="cimH" /locus_tag="BSU_38770" /old_locus_tag="BSU38770" /label="cimH gene" S_feature complement(3481589..3484071) /Source="Nicolas_S_feature" /locus_tag="new_3980704_3983186_c" /HighExp="Cold, C30, LBGstat, Paraq, GM 120, GM 90, H2O2, Oxctl, GM 25, GM 45" /AntisenseName="yxkI" /AntisenseCor="0.564471040461903" /AntisenseRegPval="-23.3" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1488" downshifts 3481975 /Source="Nicolas_upshifts" /id="D2009" /incds=0 /nref=63 /ntot=147 /MaxReadThrough="2.93791" /MaxDrop="3.97692" /score="3.68725156" /energy="-12.7" /TU="U3053" /idTUdmin="U3053" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" misc_feature 3482066..3482085 /Source="Nicolas_upshift_promotors" /id="U3054" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=2291 /SigmaFactorBS="tcaaacgaaagagcttgcttttttgcatgtccatgtttttgc aagttcccatccCATGCTATAGTAATAGTTGGaaatactagatagaaaggaatctggc a" /listShort="yxkI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3482072 /Source="Nicolas_upshifts" /id="U3054" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=2291 /SigmaFactorBS="tcaaacgaaagagcttgcttttttgcatgtccatgtttttgc aagttcccatccCATGCTATAGTAATAGTTGGaaatactagatagaaaggaatctggc a" /listShort="yxkI" /GFF_Attribute="listLong" /label="upshifts" CDS 3482112..3483800 /gene="yxkI" /locus_tag="BSU_38780" /old_locus_tag="BSU38780" /EC_number="3.4.24.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane protease" /protein_id="NP_391757.1" /db_xref="EnsemblGenomes-Gn:BSU38780" /db_xref="EnsemblGenomes-Tr:CAB15904" /db_xref="GOA:P94362" /db_xref="InterPro:IPR001915" /db_xref="SubtiList:BG12545" /db_xref="UniProtKB/Swiss-Prot:P94362" /translation="MPMGTHLFLFMLLGLGFYLISALAAKLIPAIDFWIDIVLWVGAA AYIFSHLSFMDGIVSLATMFYCYWTAMDLIVSERVEKPSGDWQEIELAKNKTRLLSDI TLTAIVFAGAVIFFIYGPDTSPLKYVILLGMISGGGALVKRILNVFSVKVFYSAALEK LHISSHYETRTYPLSDLKNIQLESTADLLKLHPLLTMYSSRLDLTTSFQQVIKLSLPG ETLFLTVKEPQKWKTILQEYTDAENNVDNVISVLPFYHRKNVKRLLGKLYFAASVKGV SAYALLVLALYALHASPWVMAVAVILYWVFNMYMSDRVLRAAMDAKSCHHPHVQAAAD KIFRSAGISHVRIYETESDDYNGMAVGMNVGRSMVILTSATLTLPQRVIEGILAHEAI HIKKRDVLSSQLLRFLYLGAVVGIFLLFEQHITHPEAHKIALWAFIMAIIILFQLYQS FCSQWMEVRADNLGASLLDGGYKQMAEALRILAVRQDEDIQKQSAYSSEAGEDELQID SLTRDKSWFFRLIDFQFAPHPPMYWRVGTLLSNKGHGVLKRWLRDRLKESITLK*" /label="yxkI CDS" gene 3482112..3483800 /gene="yxkI" /locus_tag="BSU_38780" /old_locus_tag="BSU38780" /label="yxkI gene" promotor_-35 3483798..3483807 /Source="Nicolas_upshift_promotors" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3483819..3483834 /Source="Nicolas_upshift_promotors" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3483823 /Source="Nicolas_upshifts" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="upshifts" CDS 3483858..3484058 /gene="yxzE" /locus_tag="BSU_38790" /old_locus_tag="BSU38790" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative bacteriocin" /protein_id="NP_391758.1" /db_xref="EnsemblGenomes-Gn:BSU38790" /db_xref="EnsemblGenomes-Tr:CAB15905" /db_xref="SubtiList:BG14168" /db_xref="UniProtKB/Swiss-Prot:O32284" /translation="MIVIILLFISIIVFLSVIQPQPSKNKSRQQADSGYFGYSDHSSH HDGCSSDGGFSDSGCGGGGGGD*" /label="yxzE CDS" gene 3483858..3484058 /gene="yxzE" /locus_tag="BSU_38790" /old_locus_tag="BSU38790" /label="yxzE gene" S_feature 3484059..3485003 /Source="Nicolas_S_feature" /locus_tag="new_3983174_3984118" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T2.30H, T0.0H, T-0.40H, Salt, T3.30H, T3.0H" /AntisenseName="yxkH" /AntisenseCor="0.147753218660366" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1489" CDS complement(3484072..3484911) /gene="yxkH" /locus_tag="BSU_38800" /old_locus_tag="BSU38800" /EC_number="3.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22277649; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported polysaccharide deacetylase, lipoprotein" /protein_id="NP_391759.1" /db_xref="EnsemblGenomes-Gn:BSU38800" /db_xref="EnsemblGenomes-Tr:CAB15906" /db_xref="GOA:P94361" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG12544" /db_xref="UniProtKB/Swiss-Prot:P94361" /translation="MKRLFLSIFLLGSCLALAACADQEANAEQPMPKAEQKKPEKKAV QVQKKEDDTSAWIKTEKPAKLPILMYHSISSGNSLRVPKKEFEAHMKWLHDNGYQTLT PKEASLMLTQDKKPSEKCVLITFDDGYTDNYQDAYPVLKKYGMKATIFMIGKSIGHKH HLTEEQMKEMAQHGISIESHTIDHLELNGLTPQQQQSEMADSKKLFDNMFHQQTTIIS YPVGRYNEETLKAAEKTGYQMGVTTEPGAASRDQGMYALHRVRVSPGMSGSAFGAYIE SMK*" /label="yxkH CDS" gene complement(3484072..3484911) /gene="yxkH" /locus_tag="BSU_38800" /old_locus_tag="BSU38800" /label="yxkH gene" promotor_-10 complement(3484937..3484955) /Source="Nicolas_upshift_promotors" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3484955) /Source="Nicolas_upshifts" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3484968..3484975) /Source="Nicolas_upshift_promotors" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3484970 /Source="Nicolas_upshifts" /id="D2010" /incds=0 /nref=27 /ntot=142 /MaxReadThrough="0.40982" /MaxDrop="6.50242" /score="33.6694147" /energy="-13.4" /TU="NA" /idTUdmin="U3055" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(3485018..3486115) /gene="msmX" /locus_tag="BSU_38810" /old_locus_tag="BSU38810" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16707683" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683; Product type t: transporter" /codon_start=1 /transl_table=11 /product="multiple sugar (maltodextrins) transporter ATP-binding protein" /protein_id="NP_391760.1" /db_xref="EnsemblGenomes-Gn:BSU38810" /db_xref="EnsemblGenomes-Tr:CAB15907" /db_xref="GOA:P94360" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005116" /db_xref="InterPro:IPR008995" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11954" /db_xref="UniProtKB/Swiss-Prot:P94360" /translation="MAELRMEHIYKFYDQKEPAVDDFNLHIADKEFIVFVGPSGCGKS TTLRMVAGLEEISKGDFYIEGKRVNDVAPKDRDIAMVFQNYALYPHMTVYDNIAFGLK LRKMPKPEIKKRVEEAAKILGLEEYLHRKPKALSGGQRQRVALGRAIVRDAKVFLMDE PLSNLDAKLRVQMRAEIIKLHQRLQTTTIYVTHDQTEALTMATRIVVMKDGKIQQIGT PKDVYEFPENVFVGGFIGSPAMNFFKGKLTDGLIKIGSAALTVPEGKMKVLREKGYIG KEVIFGIRPEDIHDELIVVESYKNSSIKAKINVAELLGSEIMIYSQIDNQDFIARIDA RLDIQSGDELTVAFDMNKGHFFDSETEVRIR*" /label="msmX CDS" gene complement(3485018..3486115) /gene="msmX" /locus_tag="BSU_38810" /old_locus_tag="BSU38810" /label="msmX gene" downshifts complement(3485019) /Source="Nicolas_upshifts" /id="D2011" /incds=0 /nref=81 /ntot=171 /MaxReadThrough="3.31232" /MaxDrop="7.04855" /score="29.2689404" /energy="-14.4" /TU="U3057" /idTUdmin="U3058" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3486148..3486167) /Source="Nicolas_upshift_promotors" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3486165) /Source="Nicolas_upshifts" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3486167..3486235) /Source="Nicolas_S_feature" /locus_tag="new_3985282_3985350_c" /HighExp="M0t90, M40t90, Lbstat, Lbtran, T2.0H, dia5, T2.30H, M9-stat, S2, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1490" promotor_-35 complement(3486180..3486187) /Source="Nicolas_upshift_promotors" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3486236..3487129) /gene="yxkF" /locus_tag="BSU_38820" /old_locus_tag="BSU38820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10746760" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10746760; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (regulates yxkF-msmX expression)" /protein_id="NP_391761.1" /db_xref="EnsemblGenomes-Gn:BSU38820" /db_xref="EnsemblGenomes-Tr:CAB15908" /db_xref="InterPro:IPR025736" /db_xref="SubtiList:BG12543" /db_xref="UniProtKB/Swiss-Prot:P94359" /translation="MKSLLAIYPGSIVSEELCIREGCLCFFDESNQRYISIPKTEISE KEVLVLQSFLTPADEGNQLSMKSPEENKWFSFLFSRGELPAYIKKRTRFVHFHLFGKI ERTSFTEAVRHFWPVSFVIVWIHEDRGVIVEQESEAAAEKDELESLAKVLESDFYFSV RFYAGRFYEPDECLRKHYAREQAYFLFAEKRLPQVQSVTFEMIFPFLLLETEKEKLET LLSEEAELLFGSESELRKTIKLFIENNSNVTLTAKKLHLHRNSLQYRIDKFIERSGID IKSYKGALLAYFICLQNESSE*" /label="yxkF CDS" gene complement(3486236..3487129) /gene="yxkF" /locus_tag="BSU_38820" /old_locus_tag="BSU38820" /label="yxkF gene" promotor_-10 complement(3487156..3487175) /Source="Nicolas_upshift_promotors" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3487175) /Source="Nicolas_upshifts" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3487189..3487196) /Source="Nicolas_upshift_promotors" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3487203..3487208 /Source="Nicolas_upshift_promotors" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3487224..3487242 /Source="Nicolas_upshift_promotors" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3487233 /Source="Nicolas_upshifts" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3487250..3487256 /Source="Nicolas_upshift_promotors" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3487271..3487289 /Source="Nicolas_upshift_promotors" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3487277 /Source="Nicolas_upshifts" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="upshifts" CDS 3487313..3488770 /gene="aldY" /locus_tag="BSU_38830" /old_locus_tag="BSU38830" /EC_number="1.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391762.1" /db_xref="EnsemblGenomes-Gn:BSU38830" /db_xref="EnsemblGenomes-Tr:CAB15909" /db_xref="GOA:P94358" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="PDB:4DNG" /db_xref="SubtiList:BG11903" /db_xref="UniProtKB/Swiss-Prot:P94358" /translation="MSFETLNKSFINGKWTGGESGRTEDILNPYDQSVITTASLATGK QLEDAFDIAQKAQKEWAKSTTEDRKAVLQKARGYLHENRDDIIMMIARETGGTIIKST IELEQTIAILDEAMTYTGELGGVKEVPSDIEGKTNKIYRLPLGVISSISPFNFPMNLS MRSIAPAIALGNSVVHKPDIQTAISGGTIIAKAFEHAGLPAGVLNVMLTDVKEIGDGM LTNPIPRLISFTGSTAVGRHIGEIAGRAFKRMALELGGNNPFAVLSDADVDRAVDAAI FGKFIHQGQICMIINRIIVHQDVYDEFVEKFTARVKQLPYGDQTDPKTVVGPLINERQ IEKALEIIEQAKTDGIELAVEGKRVGNVLTPYVFVGADNNSKIAQTELFAPIATIIKA GSDQEAIDMANDTEYGLSSAVFTSDLEKGEKFALQIDSGMTHVNDQSVNDSPNIAFGG NKASGVGRFGNPWVVEEFTVTKWISIQKQYRKYPF*" /label="aldY CDS" gene 3487313..3488770 /gene="aldY" /locus_tag="BSU_38830" /old_locus_tag="BSU38830" /label="aldY gene" promotor_-10 complement(3488196..3488214) /Source="Nicolas_upshift_promotors" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3488211) /Source="Nicolas_upshifts" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3488229..3488234) /Source="Nicolas_upshift_promotors" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3488751 /Source="Nicolas_upshifts" /id="D2012" /incds=0 /nref=14 /ntot=39 /MaxReadThrough="1.43471" /MaxDrop="4.03346" /score="25.9343422" /energy="-13.8" /TU="NA" /idTUdmin="U3060" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 3488795 /Source="Nicolas_upshifts" /id="D2013" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="1.40793" /MaxDrop="3.07407" /score="25.9343422" /energy="-13.8" /TU="NA" /idTUdmin="U3060" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(3488812..3489648) /gene="gdnE" /locus_tag="BSU_38840" /old_locus_tag="BSU38840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10735877, 10931887, 15096624, 15849754, 16850406, 21317561; Product type t : transporter" /codon_start=1 /transl_table=11 /product="guanidinium exporter" /protein_id="NP_391763.1" /db_xref="EnsemblGenomes-Gn:BSU38840" /db_xref="EnsemblGenomes-Tr:CAB15910" /db_xref="GOA:P94357" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG12542" /db_xref="UniProtKB/Swiss-Prot:P94357" /translation="MKKRMLDVLMLVIGAFFFALAVNLFAIPNDLGEGGVTGITLILY YLFQWSPGVTNFILNAFLLLIGYKFLDGKTTVYTIIAVAANSLFLHLTHGWSIPSDEL IINTIFAGVFAGVGIGMIIRVGGTTAGSAILARIANKYLDWNISYALLFFDLIVVFSS YFIIGAEKMMFTIVMLYIGTKVMDFIIEGLNTKKAITVISENKSEIAEQVNTLMDRGV TILSGKGNYTGQSKEILYIVINKQELSMLKKIIRSCDKKAFVIVHDVRDVFGEGFVDI SK*" /label="gdnE CDS" gene complement(3488812..3489648) /gene="gdnE" /locus_tag="BSU_38840" /old_locus_tag="BSU38840" /label="gdnE gene" downshifts complement(3488830) /Source="Nicolas_upshifts" /id="D2014" /incds=0 /nref=19 /ntot=137 /MaxReadThrough="1.00689" /MaxDrop="4.07213" /score="21.5028874" /energy="-13.8" /TU="NA" /idTUdmin="U3062" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" misc_RNA complement(3489725..3489827) /gene="gdwB" /locus_tag="BSU_misc_RNA_60" /product="guanidine riboswitch (type I)" /experiment="publication(s) with functional evidences, PMID:21317561, 27989440, 28096518" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21317561, 27989440, 28096518" /label="gdwB RNA" gene complement(3489725..3489827) /gene="gdwB" /locus_tag="BSU_misc_RNA_60" /label="gdwB gene" downshifts complement(3489751) /Source="Nicolas_upshifts" /id="D2015" /incds=0 /nref=194 /ntot=247 /MaxReadThrough="3.21415" /MaxDrop="5.58394" /score="-0.190335837" /energy="-10.7" /TU="U3062" /idTUdmin="U3065" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3489853..3489872) /Source="Nicolas_upshift_promotors" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3489864) /Source="Nicolas_upshifts" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3489866..3490607) /Source="Nicolas_S_feature" /locus_tag="new_3988981_3989722_c" /HighExp="S6, S8, S7, C30, S5, Gly, C90, Fru, BT, Pyr" /AntisenseName="yxkC" /AntisenseCor="-0.38162570069976298" /AntisenseRegPval="-10" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1491" promotor_-35 complement(3489886..3489892) /Source="Nicolas_upshift_promotors" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3489944..3489951 /Source="Nicolas_upshift_promotors" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3489964..3489982 /Source="Nicolas_upshift_promotors" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3489973 /Source="Nicolas_upshifts" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="upshifts" S_feature 3489983..3490068 /Source="Nicolas_S_feature" /locus_tag="new_3989098_3989183" /HighExp="Cold, SMM, MG 150, GM 90, Glu, C30, GM 150, GM-0.2, GM 15, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1492" promotor_-35 3490044..3490051 /Source="Nicolas_upshift_promotors" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3490065..3490084 /Source="Nicolas_upshift_promotors" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3490070 /Source="Nicolas_upshifts" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="upshifts" CDS 3490216..3490758 /gene="yxkC" /locus_tag="BSU_38850" /old_locus_tag="BSU38850" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12823818, 15033535" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391764.2" /db_xref="EnsemblGenomes-Gn:BSU38850" /db_xref="EnsemblGenomes-Tr:CAB15911" /db_xref="GOA:P94356" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="SubtiList:BG12541" /db_xref="UniProtKB/Swiss-Prot:P94356" /translation="MRHKIITFILAVVVIIIIGNMIGGGGGSEATSKTSSSSKAETEK TYNIGDTVKTEKTEVTVTKVEDRDTVGTQYVEKKASEGGTIVAVQYTIKNVSKKPISS FSIPTVKLVDADGTSYDSDIDASVNYATETKVDNSKILSDLNPNIKVTGVKAFEVDKE AYAKGTWKLKFSNDVIVKIK*" /label="yxkC CDS" gene 3490216..3490758 /gene="yxkC" /locus_tag="BSU_38850" /old_locus_tag="BSU38850" /label="yxkC gene" promotor_-10 complement(3490583..3490602) /Source="Nicolas_upshift_promotors" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3490607) /Source="Nicolas_upshifts" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3490616..3490625) /Source="Nicolas_upshift_promotors" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3490748 /Source="Nicolas_upshifts" /id="D2016" /incds=0 /nref=78 /ntot=276 /MaxReadThrough="4.33141" /MaxDrop="6.78221" /score="9.28209494" /energy="-14.4" /TU="U3063,U3064" /idTUdmin="U3064" /TUdmin="-181" /isTUend="FALSE" /label="downshifts" S_feature 3490793..3491115 /Source="Nicolas_S_feature" /locus_tag="new_3989908_3990230" /HighExp="Cold, C30, Heat, Fru, Glu, C90, BMM, Glucon, M/G, Mal" /AntisenseName="galE" /AntisenseCor="0.165797390333391" /AntisenseRegPval="-2.2000000000000002" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1493" CDS complement(3490833..3491852) /gene="galE" /locus_tag="BSU_38860" /old_locus_tag="BSU38860" /EC_number="5.1.3.7" /EC_number="5.1.3.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1906927, 9555917, 14597172" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1906927, 9555917, 14597172; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose 4-epimerase" /protein_id="NP_391765.1" /db_xref="EnsemblGenomes-Gn:BSU38860" /db_xref="EnsemblGenomes-Tr:CAB15912" /db_xref="GOA:P55180" /db_xref="InterPro:IPR005886" /db_xref="InterPro:IPR008089" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11837" /db_xref="UniProtKB/Swiss-Prot:P55180" /translation="MAILVTGGAGYIGSHTCVELLNSGYEIVVLDNLSNSSAEALNRV KEITGKDLTFYEADLLDREAVDSVFAENEIEAVIHFAGLKAVGESVAIPLKYYHNNLT GTFILCEAMEKYGVKKIVFSSSATVYGVPETSPITEDFPLGATNPYGQTKLMLEQILR DLHTADNEWSVALLRYFNPFGAHPSGRIGEDPNGIPNNLMPYVAQVAVGKLEQLSVFG NDYPTKDGTGVRDYIHVVDLAEGHVKALEKVLNSTGADAYNLGTGTGYSVLEMVKAFE KVSGKEVPYRFADRRPGDIATCFADPAKAKRELGWEAKRGLEEMCADSWRWQSSNVNG YKSAE*" /label="galE CDS" gene complement(3490833..3491852) /gene="galE" /locus_tag="BSU_38860" /old_locus_tag="BSU38860" /label="galE gene" downshifts complement(3490851) /Source="Nicolas_upshifts" /id="D2017" /incds=0 /nref=235 /ntot=261 /MaxReadThrough="1.7919" /MaxDrop="7.32805" /score="24.6899971" /energy="-14.8" /TU="NA" /idTUdmin="U3066" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3491878..3491897) /Source="Nicolas_upshift_promotors" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3491892) /Source="Nicolas_upshifts" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3491912..3491915) /Source="Nicolas_upshift_promotors" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3491967..3492473) /gene="yxkA" /locus_tag="BSU_38870" /old_locus_tag="BSU38870" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative phospholipid binding protein" /protein_id="NP_391766.1" /db_xref="EnsemblGenomes-Gn:BSU38870" /db_xref="EnsemblGenomes-Tr:CAB15913" /db_xref="InterPro:IPR005247" /db_xref="InterPro:IPR008914" /db_xref="InterPro:IPR036610" /db_xref="SubtiList:BG11899" /db_xref="UniProtKB/Swiss-Prot:P55185" /translation="MNIYVEANPYLHDKYSKYADEKYKREGNPFVSFPIHFDDIPSGA KTLALTFIDHDAIPVCGFSWIHWTAANIPAYIGELPEHASEERQDLMIQGQNSFASPL AGSNDPKVIHQYCGPTPPDKDHAYTLTVYALDAELNLQPGFYLNELYQEMKEHILAET SIELLARV*" /label="yxkA CDS" gene complement(3491967..3492473) /gene="yxkA" /locus_tag="BSU_38870" /old_locus_tag="BSU38870" /label="yxkA gene" promotor_-10 complement(3492479..3492498) /Source="Nicolas_upshift_promotors" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3492501) /Source="Nicolas_upshifts" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3492503..3492506 /Source="Nicolas_upshift_promotors" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3492512..3492518) /Source="Nicolas_upshift_promotors" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3492521..3492540 /Source="Nicolas_upshift_promotors" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3492524 /Source="Nicolas_upshifts" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="upshifts" CDS 3492603..3493478 /gene="yxjO" /locus_tag="BSU_38880" /old_locus_tag="BSU38880" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12169591; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391767.1" /db_xref="EnsemblGenomes-Gn:BSU38880" /db_xref="EnsemblGenomes-Tr:CAB15914" /db_xref="GOA:P55181" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11898" /db_xref="UniProtKB/Swiss-Prot:P55181" /translation="MDLKWLQTFIAAAESESFREAAEHLYLTQPAVSQHMRKLEDELD MRLFLHSGRRVVLTDEGRLFLPYAKEMIHVYQAGKQKVSQWKQGYSRSLTLAVHPYIA SYILPRFLPAYIQKHPHVELSTHVAGSDAIKQAVEHNEADIGLSRKDPNTNTLYYQHI CEGTLCLAAPFQESRPDAASVLTRYRLLTHDHPSYGDAFLDNIRSHYPYLQMMAVGQT DTAVHMMKAGMGASFLPTYIIKQEEAEKKLMAVSTPAHLELPASQTFMMWKRNSEDIQ HFHAMLHDFMQREQV*" /label="yxjO CDS" gene 3492603..3493478 /gene="yxjO" /locus_tag="BSU_38880" /old_locus_tag="BSU38880" /label="yxjO gene" S_feature complement(3492853..3492941) /Source="Nicolas_S_feature" /locus_tag="new_3991968_3992056_c" /HighExp="GM 60, MG-0.1, MG 10, GM 5, S8, T0.30H, BC, S6, GM 15, GM 150" /AntisenseName="yxjO" /AntisenseCor="0.14032494397598999" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0669" /TUlongSig="NA" /TUlongPSig="NA" /label="S1494" downshifts complement(3492875) /Source="Nicolas_upshifts" /id="D2018" /incds=1 /nref=22 /ntot=45 /MaxReadThrough="0.10815" /MaxDrop="6.05884" /score="5.06408541" /energy="-5.6" /TU="NA" /idTUdmin="U3069" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(3492901..3493001) /Source="Nicolas_upshift_promotors" /id="U3069" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.507492507492508" /psig="0.066933066933067" /xcortree=1478 /SigmaFactorBS="tttaatagcgtcagatccagccacatgagttgaaagctcgac atgcggatgtttttggatataggctggcagaaagcgaggcaagatataggacgcaatg t" /listShort="S1494" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3492941) /Source="Nicolas_upshifts" /id="U3069" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.507492507492508" /psig="0.066933066933067" /xcortree=1478 /SigmaFactorBS="tttaatagcgtcagatccagccacatgagttgaaagctcgac atgcggatgtttttggatataggctggcagaaagcgaggcaagatataggacgcaatg t" /listShort="S1494" /GFF_Attribute="listLong" /label="upshifts" CDS 3493556..3494029 /gene="yxjN" /locus_tag="BSU_38890" /old_locus_tag="BSU38890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391768.1" /db_xref="EnsemblGenomes-Gn:BSU38890" /db_xref="EnsemblGenomes-Tr:CAB15915" /db_xref="GOA:P55182" /db_xref="InterPro:IPR009916" /db_xref="InterPro:IPR020223" /db_xref="SubtiList:BG11897" /db_xref="UniProtKB/Swiss-Prot:P55182" /translation="MAMSPYIFIVLILIILSMYRERTVKPGKLLIIPLLLLWGVSASF QPAYFHSVLHVAISGILLLIGLACGFGIGKMVNVRIHPETGKVTSRGSLGSVILILVI LSLRMAARTWLPESNEMFIAIIHSMFFVPLGTITARNIMLYKAYRRLTAGKVSIQ*" /label="yxjN CDS" gene 3493556..3494029 /gene="yxjN" /locus_tag="BSU_38890" /old_locus_tag="BSU38890" /label="yxjN gene" CDS 3494047..3495267 /gene="yxjM" /locus_tag="BSU_38900" /old_locus_tag="BSU38900" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YxjL]" /protein_id="NP_391769.1" /db_xref="EnsemblGenomes-Gn:BSU38900" /db_xref="EnsemblGenomes-Tr:CAB15916" /db_xref="GOA:P55183" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11896" /db_xref="UniProtKB/Swiss-Prot:P55183" /translation="MNGQTPARHYYKKLVPSLILILNCIQFLSHPTKADPILLAFVFA VYLAFIWIIPYVASTAVSLSIFIGLWLLTDFFWAVSGQEQGAAYFLIVFLMIYAAFRL PSRLSLIFTACLIGGNILLLSSQGGSLNTIISNISIMLGLYVLFSSMRFRREARREAE RNHAELAKMHVQLEHAHKELQKAHAELQEASVLSLRYAVLEERTRIARDIHDSIGHEL TSVIVQLQSLPYILKSSKEDSEKVIQNVLSVARECLQEVRSVVHQMGRSESMVGLTAL RGLIHQVEERSGLHVSLDTAGLSEESWPPNVSETIYRILQEALTNIIRHADASHAAAV ISNDKSHLYVTITDDGQFTGSLTYGFGLTGMKERAEKAGGSLTFSAVQPSGLKIELSL PLMTTNKEQKDEQR*" /label="yxjM CDS" gene 3494047..3495267 /gene="yxjM" /locus_tag="BSU_38900" /old_locus_tag="BSU38900" /label="yxjM gene" CDS 3495254..3495910 /gene="yxjL" /locus_tag="BSU_38910" /old_locus_tag="BSU38910" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YxjM]" /protein_id="NP_391770.1" /db_xref="EnsemblGenomes-Gn:BSU38910" /db_xref="EnsemblGenomes-Tr:CAB15917" /db_xref="GOA:P55184" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11895" /db_xref="UniProtKB/Swiss-Prot:P55184" /translation="MNKDKIRVALADDQPLVREGFRYVINAQTDMTVSGEAGDGHDII ALAKQTKPDVILMDVQMPRCSGIEAAKDIMSALPNTKIVILTTFDTEEYVFEGIRAGA VGYLLKDTLPEELIDAIRAAARGEAIFRTVTAAKIISETFRAKQQTHAEELAEPFTKR ELEVLQQMAYGLRNEDIAEKLFVSESTVKTHVHRILQKCNAQDRTQAVVFAIRNGIVQ *" /label="yxjL CDS" gene 3495254..3495910 /gene="yxjL" /locus_tag="BSU_38910" /old_locus_tag="BSU38910" /label="yxjL gene" promotor_-35 3495908..3495913 /Source="Nicolas_upshift_promotors" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3495927..3495946 /Source="Nicolas_upshift_promotors" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3495930 /Source="Nicolas_upshifts" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="upshifts" CDS 3495960..3497192 /gene="pepT" /locus_tag="BSU_38920" /old_locus_tag="BSU38920" /EC_number="3.4.11.4" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8978088, 10987140" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8978088, 10987140; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidase T (tripeptidase)" /protein_id="NP_391771.1" /db_xref="EnsemblGenomes-Gn:BSU38920" /db_xref="EnsemblGenomes-Tr:CAB15918" /db_xref="GOA:P55179" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010161" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11842" /db_xref="UniProtKB/Swiss-Prot:P55179" /translation="MKEEIIERFTTYVKVDTQSDESVDTCPSTPGQLTLGNMLVDELK SIGMQDAAIDENGYVMATLPSNTEKDVPTIGFLAHVDTATDFTGKNVNPQIIESYDGK DIVLNEQLQVTLSPDQFPELSGYKGHTLITTDGTTLLGADNKAGIAEIMTAMDYLIKH PEIKHGTIRVAFTPDEEIGRGPHKFDVKRFNASFAYTVDGGPLGELEYESFNAAAAKI TIKGNNVHPGTAKGKMINSAKIAMKLNSLLPADEAPEYTEGYEGFYHLLSIQGDVEET KLHYIIRDFDKENFQNRKETMKRAVEELQNEYGQDRILLDMNDQYYNMREKIEPVIEI VNIAKQAMENLGIEPKISPIRGGTDGSQLSYMGLPTPNIFTGGENFHGKFEYISVDNM VKAVNVIVEIAKQFEAQA*" /label="pepT CDS" gene 3495960..3497192 /gene="pepT" /locus_tag="BSU_38920" /old_locus_tag="BSU38920" /label="pepT gene" downshifts complement(3495977) /Source="Nicolas_upshifts" /id="D2019" /incds=0 /nref=4 /ntot=116 /MaxReadThrough="0.86167" /MaxDrop="3.19485" /score="-2.15704435" /energy="-9.1" /TU="NA" /idTUdmin="U3069" /TUdmin="-3102" /isTUend="FALSE" /label="downshifts" downshifts 3497177 /Source="Nicolas_upshifts" /id="D2020" /incds=0 /nref=203 /ntot=244 /MaxReadThrough="3.3949" /MaxDrop="6.35116" /score="27.2051031" /energy="-13.5" /TU="U3070" /idTUdmin="U3070" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 3497238..3497247 /Source="Nicolas_upshift_promotors" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3497260..3497275 /Source="Nicolas_upshift_promotors" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" S_feature 3497262..3497484 /Source="Nicolas_S_feature" /locus_tag="new_3996377_3996599" /HighExp="T-0.40H, T0.30H, T0.0H, T-1.40H, T1.0H, T-1.10H, T3.30H, T2.0H, T1.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.80396299999999998" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1495" upshifts 3497262 /Source="Nicolas_upshifts" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="upshifts" downshifts 3497441 /Source="Nicolas_upshifts" /id="D2021" /incds=0 /nref=162 /ntot=247 /MaxReadThrough="4.83682" /MaxDrop="4.66302" /score="-1.57383757" /energy="-6.2" /TU="U3071" /idTUdmin="U3070" /TUdmin=242 /isTUend="FALSE" /label="downshifts" promotor_-35 3497495..3497501 /Source="Nicolas_upshift_promotors" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="promotor_-35" S_feature 3497514..3497614 /Source="Nicolas_S_feature" /locus_tag="new_3996629_3996729" /HighExp="Etha, Gly, Sw, Salt, B60, T0.30H, LoTm, M9-stat, T1.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1496" upshifts 3497514 /Source="Nicolas_upshifts" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="upshifts" promotor_-10 3497516..3497534 /Source="Nicolas_upshift_promotors" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="promotor_-10" promotor_-35 3497593..3497600 /Source="Nicolas_upshift_promotors" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3497614..3497632 /Source="Nicolas_upshift_promotors" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" S_feature 3497616..3497713 /Source="Nicolas_S_feature" /locus_tag="new_3996731_3996828" /HighExp="Etha, T0.30H, Gly, T1.0H, Sw, Salt, T1.30H, GM 15, B60, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB, SigWXY" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1497" upshifts 3497616 /Source="Nicolas_upshifts" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="upshifts" CDS 3497714..3497977 /gene="yxjJ" /locus_tag="BSU_38930" /old_locus_tag="BSU38930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391772.1" /db_xref="EnsemblGenomes-Gn:BSU38930" /db_xref="EnsemblGenomes-Tr:CAB15919" /db_xref="GOA:P94353" /db_xref="SubtiList:BG12540" /db_xref="UniProtKB/Swiss-Prot:P94353" /translation="MLFIDLEFFEYFLAFYPYNREYQNFFWEVCNMILFIIIALCGYL LFSFSKDNRRKPQKTSPLPAAAPHHNNLIDLDAIRQKRRMHLS*" /label="yxjJ CDS" gene 3497714..3497977 /gene="yxjJ" /locus_tag="BSU_38930" /old_locus_tag="BSU38930" /label="yxjJ gene" promotor_-35 3497741..3497744 /Source="Nicolas_upshift_promotors" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3497759..3497778 /Source="Nicolas_upshift_promotors" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" upshifts 3497771 /Source="Nicolas_upshifts" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="upshifts" downshifts 3497925 /Source="Nicolas_upshifts" /id="D2022" /incds=0 /nref=4 /ntot=92 /MaxReadThrough="7.33654" /MaxDrop="3.1638" /score="-1.57383757" /energy="-6.2" /TU="U3072,U3073,U3074" /idTUdmin="U3073" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 3497969 /Source="Nicolas_upshifts" /id="D2023" /incds=0 /nref=44 /ntot=188 /MaxReadThrough="5.58502" /MaxDrop="4.5161" /score="-1.57383757" /energy="-6.2" /TU="U3072,U3073,U3074" /idTUdmin="U3073" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-35 3498044..3498053 /Source="Nicolas_upshift_promotors" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3498059 /Source="Nicolas_upshifts" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3498065..3498080 /Source="Nicolas_upshift_promotors" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3498106..3498594 /gene="yxjI" /locus_tag="BSU_38940" /old_locus_tag="BSU38940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391773.1" /db_xref="EnsemblGenomes-Gn:BSU38940" /db_xref="EnsemblGenomes-Tr:CAB15920" /db_xref="InterPro:IPR007612" /db_xref="InterPro:IPR025659" /db_xref="SubtiList:BG12539" /db_xref="UniProtKB/Swiss-Prot:P94352" /translation="MIELFMKQKMFSFKDAFHIYDRDEQETFKVEGRFFSLGDSLQMT DSSGKTLVSIEQKLMSLLPRYEISIGGKTVCEVTKKVTFSKPKFVISGLNWEIDGDLW RDEFQLTDGENVRMSVSKKWLSWGDSYHLQIAYEEDVLICTAIAIVLDMVLYNDEDES IF*" /label="yxjI CDS" gene 3498106..3498594 /gene="yxjI" /locus_tag="BSU_38940" /old_locus_tag="BSU38940" /label="yxjI gene" promotor_-35 3498599..3498606 /Source="Nicolas_upshift_promotors" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3498620..3498639 /Source="Nicolas_upshift_promotors" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3498630 /Source="Nicolas_upshifts" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 3498660..3498766 /gene="mswI" /locus_tag="BSU_misc_RNA_61" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswI RNA" gene 3498660..3498766 /gene="mswI" /locus_tag="BSU_misc_RNA_61" /label="mswI gene" downshifts 3498761 /Source="Nicolas_upshifts" /id="D2024" /incds=0 /nref=22 /ntot=102 /MaxReadThrough="7.18775" /MaxDrop="3.7896" /score="9.64734237" /energy="-14.5" /TU="U3075,U3076" /idTUdmin="U3072" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3498849..3499982 /gene="yxjH" /locus_tag="BSU_38950" /old_locus_tag="BSU38950" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12456320, 14563871, 17098890, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyl-tetrahydrofolate methyltransferase (biofilm formation)" /protein_id="NP_391774.2" /db_xref="EnsemblGenomes-Gn:BSU38950" /db_xref="EnsemblGenomes-Tr:CAB15921" /db_xref="GOA:P42319" /db_xref="InterPro:IPR002629" /db_xref="SubtiList:BG11157" /db_xref="UniProtKB/Swiss-Prot:P42319" /translation="MAQQTNVAGQKTEKQRKAPFRADHVGSLLRSVPVKEARQKKAAG EMTAEQLRDIENQEITRIVEKQKEIGLDVVTDGEFRRSWWHYDFLEGLDGVEPFIPAE GIQFHNTKTKARSIKVTGKLDFTSHPALGDYQFLHEIAGNATPKLTIPSPNMLFFGEK ADKGIYDDQEEYFHDMAQAYKKAIKAFYDAGCRYLQLDDTSWSLFFEDKGREVVRALG GDPETLPAIFAKTINDAVADRPDDLTITMHICRGNFRSTWAASGGYDAVAETILDGLN LDGLFLEYDDDRSGNFDPLRFVKRKDLQIVLGLITSKYGELENPEDVKRRINEAARFV SLDQLCLSPQCGFASTEEGNLLTEEQQWAKLRHVIDIANDVWR*" /label="yxjH CDS" gene 3498849..3499982 /gene="yxjH" /locus_tag="BSU_38950" /old_locus_tag="BSU38950" /label="yxjH gene" S_feature complement(3499122..3499365) /Source="Nicolas_S_feature" /locus_tag="new_3998237_3998480_c" /HighExp="dia15, Diami, H2O2, dia5, C90, Paraq, Sw, BC, LBGstat, Lbtran" /AntisenseName="yxjH" /AntisenseCor="-0.34694665046491102" /AntisenseRegPval="-8.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1498" promotor_-10 complement(3499360..3499379) /Source="Nicolas_upshift_promotors" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3499369) /Source="Nicolas_upshifts" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3499394..3499401) /Source="Nicolas_upshift_promotors" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3499988..3499995 /Source="Nicolas_upshift_promotors" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3500010..3500029 /Source="Nicolas_upshift_promotors" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3500016 /Source="Nicolas_upshifts" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 3500051..3500157 /gene="mswJ" /locus_tag="BSU_misc_RNA_62" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswJ RNA" gene 3500051..3500157 /gene="mswJ" /locus_tag="BSU_misc_RNA_62" /label="mswJ gene" downshifts 3500104 /Source="Nicolas_upshifts" /id="D2025" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="8.35488" /MaxDrop="3.50346" /score="29.0146782" /energy="-14.5" /TU="U3075,U3076,U3078" /idTUdmin="U3075" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" S_feature 3500158..3500234 /Source="Nicolas_S_feature" /locus_tag="new_3999273_3999349" /HighExp="MG 5, MG t5, T1.0H, MG 10, T1.30H, BMM, T0.30H, T-0.40H, T0.0H, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigWXY" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigD, SigB, SigWXY" /TUlongPSig="0.554, 1, 1, 1" /label="S1499" CDS 3500235..3501371 /gene="yxjG" /locus_tag="BSU_38960" /old_locus_tag="BSU38960" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12456320, 14563871, 17098890, 17114254, 21749987; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltetrahydrofolate methyltransferase (biofilm formation)" /protein_id="NP_391775.3" /db_xref="EnsemblGenomes-Gn:BSU38960" /db_xref="EnsemblGenomes-Tr:CAB15922" /db_xref="GOA:P42318" /db_xref="InterPro:IPR002629" /db_xref="SubtiList:BG11156" /db_xref="UniProtKB/Swiss-Prot:P42318" /translation="MSQQTTPAEQKSLQRKKPPFRADQVGSLLRSEPVKKARLQKAAG EMTAEQLRQIENDEIIRIVEKQKETGLNVVTDGEFRRAWWHFDFLENLDGVEPFTPEQ GIQFHNVQTKARGIKVTGDIDFSTHPMLEDYSFLHSIAGDATPKMTIPSPNMLFFRGK LEKDEYKNDYQLFQHDVSKAYKKAIQAFYDRGCRYLQLDDTAWAVFLSEKGLKQIEAF GTTPDELRQLFAKSINDAIADRPDDLTVTMHICRGNFQSTWTAEGGYDAAAETIFDGL NLDGLFLEYDDSRSGGFEPLRYVKRSDLQLVLGLVTSKFGELENPDDVKRRIEEASRY VSLDQLCLSPQCGFASTEEGNKLTEEQQWAKLRHVVEIANDVWK*" /label="yxjG CDS" gene 3500235..3501371 /gene="yxjG" /locus_tag="BSU_38960" /old_locus_tag="BSU38960" /label="yxjG gene" downshifts 3501358 /Source="Nicolas_upshifts" /id="D2026" /incds=0 /nref=81 /ntot=187 /MaxReadThrough="4.24668" /MaxDrop="5.8124" /score="11.1243305" /energy="-12.8" /TU="U3076,U3078" /idTUdmin="U3075" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3501424..3502197) /gene="yxjF" /locus_tag="BSU_38970" /old_locus_tag="BSU38970" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydroxyacid dehydrogenase" /protein_id="NP_391776.2" /db_xref="EnsemblGenomes-Gn:BSU38970" /db_xref="EnsemblGenomes-Tr:CAB15923" /db_xref="GOA:P42317" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011294" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11155" /db_xref="UniProtKB/Swiss-Prot:P42317" /translation="MRKQVALVTGAAGGIGFEIAREFAREGASVIVSDLRPEACEKAA SKLAEEGFDAAAIPYDVTKEAQVADTVNVIQKQYGRLDILVNNAGIQHVAPIEEFPTD TFEQLIKVMLTAPFIAMKHVFPIMKKQQFGRIINIASVNGLVGFAGKSAYNSAKHGVI GLTKVGALEGAPHGITVNALCPGYVDTQLVRNQLSDLSKTRNVPYDSVLEQVIFPLVP QKRLLSVKEIADYAVFLASEKAKGVTGQAVVLDGGYTAQ*" /label="yxjF CDS" gene complement(3501424..3502197) /gene="yxjF" /locus_tag="BSU_38970" /old_locus_tag="BSU38970" /label="yxjF gene" downshifts complement(3501434) /Source="Nicolas_upshifts" /id="D2027" /incds=0 /nref=23 /ntot=63 /MaxReadThrough="0.65" /MaxDrop="6.97604" /score="24.6585594" /energy="-12.8" /TU="NA" /idTUdmin="U3079" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3502214..3502864) /gene="scoB" /locus_tag="BSU_38980" /old_locus_tag="BSU38980" /EC_number="2.8.3.5" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17363272, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl CoA-transferase (subunit B)" /protein_id="NP_391777.1" /db_xref="EnsemblGenomes-Gn:BSU38980" /db_xref="EnsemblGenomes-Tr:CAB15924" /db_xref="GOA:P42316" /db_xref="InterPro:IPR004164" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012791" /db_xref="PDB:3CDK" /db_xref="SubtiList:BG11154" /db_xref="UniProtKB/Swiss-Prot:P42316" /translation="MKEARKRMVKRAVQEIKDGMNVNLGIGMPTLVANEIPDGVHVML QSENGLLGIGPYPLEGTEDADLINAGKETITEVTGASYFDSAESFAMIRGGHIDLAIL GGMEVSEQGDLANWMIPGKMVKGMGGAMDLVNGAKRIVVIMEHVNKHGESKVKKTCSL PLTGQKVVHRLITDLAVFDFVNGRMTLTELQDGVTIEEVYEKTEADFAVSQSVLNS*" /label="scoB CDS" gene complement(3502214..3502864) /gene="scoB" /locus_tag="BSU_38980" /old_locus_tag="BSU38980" /label="scoB gene" CDS complement(3502861..3503577) /gene="scoA" /locus_tag="BSU_38990" /old_locus_tag="BSU38990" /EC_number="2.8.3.5" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17363272; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl CoA-transferase (subunit A)" /protein_id="NP_391778.1" /db_xref="EnsemblGenomes-Gn:BSU38990" /db_xref="EnsemblGenomes-Tr:CAB15925" /db_xref="GOA:P42315" /db_xref="InterPro:IPR004163" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012792" /db_xref="PDB:3CDK" /db_xref="SubtiList:BG11153" /db_xref="UniProtKB/Swiss-Prot:P42315" /translation="MGKVLSSSKEAAKLIHDGDTLIAGGFGLCGIPEQLILSIRDQGV KDLTVVSNNCGVDDWGLGLLLANKQIKKMIASYVGENKIFERQFLSGELEVELVPQGT LAERIRAGGAGIPGFYTATGVGTSIAEGKEHKTFGGRTYVLERGITGDVAIVKAWKAD TMGNLIFRKTARNFNPIAAMAGKITIAEAEEIVEAGELDPDHIHTPGIYVQHVVLGAS QEKRIEKRTVQQASGKGEAK*" /label="scoA CDS" gene complement(3502861..3503577) /gene="scoA" /locus_tag="BSU_38990" /old_locus_tag="BSU38990" /label="scoA gene" CDS complement(3503601..3505019) /gene="yxjC" /locus_tag="BSU_39000" /old_locus_tag="BSU39000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative acid metabolite permease" /protein_id="NP_391779.3" /db_xref="EnsemblGenomes-Gn:BSU39000" /db_xref="EnsemblGenomes-Tr:CAB15926" /db_xref="GOA:P42314" /db_xref="SubtiList:BG11152" /db_xref="UniProtKB/Swiss-Prot:P42314" /translation="MELIIILLALGLLMFTAYRGFSVILFAPICALFAVLLTDPSHVL PFFSSIFMEKMAGFIKLYFPVFLLGAIFGKVVEMAGLAASIAKTIVRLVGAKRAILAI VLMGAVLTYSGVSLFVVVFAVYPFAKNMFQEANIPKRLIPGTIALGAFTFTMDALPGT PQIQNVIPTSFFKTDIYAAPWLGLMGAVIVLAAGMLYLESRRKKAQASGEGYGGFDSQ NAPAPESIESAAEPDKSPIRHALAFVPLILVGAVNKYFTIYLPKWYPNGFDFSSIGLK EFGRLDISSAAAIWSVEIALVIGIITTILFDWRSVFAQLKEGLNEGIGGALLASMNTG AEYGFGGIIAALPGFHKLSSGISHTFTDPLVNGAVTTTALAGITGSASGGMGIALSAM SEQYLQAIQAYNIPPEVMHRVISMASGGMDTLPHNGAVITLLAVTGLTHRQSYRDIFA ITLIKTAAVFAVIAIYSLTGLV*" /label="yxjC CDS" gene complement(3503601..3505019) /gene="yxjC" /locus_tag="BSU_39000" /old_locus_tag="BSU39000" /label="yxjC gene" promotor_-10 complement(3504187..3504205) /Source="Nicolas_upshift_promotors" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3504206) /Source="Nicolas_upshifts" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3504221..3504226) /Source="Nicolas_upshift_promotors" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3505020..3505104) /Source="Nicolas_S_feature" /locus_tag="new_4004135_4004219_c" /HighExp="S5, S4, S6, S3, S7, M9-stat, B60, S8, T4.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1500" promotor_-10 complement(3505088..3505106) /Source="Nicolas_upshift_promotors" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3505104) /Source="Nicolas_upshifts" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3505122..3505127) /Source="Nicolas_upshift_promotors" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3505173..3506021) /gene="rlmA" /locus_tag="BSU_39010" /old_locus_tag="BSU39010" /EC_number="2.1.1.188" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11967079, 14999102, 18406425, 23716046; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m(1)G748 methyltransferase (class II)" /protein_id="NP_391780.1" /db_xref="EnsemblGenomes-Gn:BSU39010" /db_xref="EnsemblGenomes-Tr:CAB15927" /db_xref="GOA:P42313" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR016718" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11151" /db_xref="UniProtKB/Swiss-Prot:P42313" /translation="MKRTVDFSMFRCPLCDSSMDAASGKSLICTERGHTFDLSRHGYV NFLTKPVKTSYGAELFEARSRLIGECGFFDPLHDAIAELISHPKSGHEAFTILDSGCG EGSHLNALCGFDYAGKAAIGTGIDLSKDGILKASKAFKDLMWAVADVARAPFHDRQFD VVLSIFSPSNYAEFHRLLKNDGMLIKVVPRSDYLIELRQFLYTDSPRRTYSNTAAVER FTANAAHSRPVRLRYVKTLDQQAIHWLLKMTPLAWSAPKDRVSLLKEMKSADITVDVD ILIGMK*" /label="rlmA CDS" gene complement(3505173..3506021) /gene="rlmA" /locus_tag="BSU_39010" /old_locus_tag="BSU39010" /label="rlmA gene" downshifts complement(3505183) /Source="Nicolas_upshifts" /id="D2028" /incds=0 /nref=54 /ntot=218 /MaxReadThrough="1.618" /MaxDrop="4.63737" /score="17.0758624" /energy="-15.1" /TU="NA" /idTUdmin="U3081" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" S_feature complement(3506022..3506207) /Source="Nicolas_S_feature" /locus_tag="new_4005137_4005322_c" /HighExp="B60, LBGstat, LPhT, M9-stat, C30, T0.30H, HPh, Oxctl, Heat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1501" promotor_-10 complement(3506196..3506215) /Source="Nicolas_upshift_promotors" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3506207) /Source="Nicolas_upshifts" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3506209..3506934) /Source="Nicolas_S_feature" /locus_tag="new_4005324_4006049_c" /HighExp="LBGstat, C30, GM 25, Heat, GM 10, GM 45, GM 60, GM 90, T0.30H, GM 120" /AntisenseName="NA" /AntisenseCor="0.20859849915331599" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1502" promotor_-35 complement(3506231..3506235) /Source="Nicolas_upshift_promotors" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3506369..3506376 /Source="Nicolas_upshift_promotors" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3506389..3506408 /Source="Nicolas_upshift_promotors" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3506398 /Source="Nicolas_upshifts" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 3506408..3506510 /gene="gswB" /locus_tag="BSU_misc_RNA_63" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477; Product type n: RNA" /label="gswB RNA" gene 3506408..3506510 /gene="gswB" /locus_tag="BSU_misc_RNA_63" /label="gswB gene" S_feature 3506511..3506614 /Source="Nicolas_S_feature" /locus_tag="new_4005626_4005729" /HighExp="C90, G180, M40t45, dia15, LBGexp, Lbexp, Lbtran, G135, Mt0, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1503" promotor_-35 3506586..3506592 /Source="Nicolas_upshift_promotors" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3506606..3506617 /Source="Nicolas_upshift_promotors" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3506616 /Source="Nicolas_upshifts" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="upshifts" CDS 3506637..3507830 /gene="nupG" /locus_tag="BSU_39020" /old_locus_tag="BSU39020" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12787499, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="purine nucleoside transporter" /protein_id="NP_391781.2" /db_xref="EnsemblGenomes-Gn:BSU39020" /db_xref="EnsemblGenomes-Tr:CAB15928" /db_xref="GOA:P42312" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG11150" /db_xref="UniProtKB/Swiss-Prot:P42312" /translation="MYFLLNLVGLIVIMAVVFLCSPQKKKIKWRPIITLIVLELLITW FMLGTKVGSWAIGKIGDFFTWLIACASDGIAFAFPSVMANETVDFFFSALLPIIFIVT FFDILTYFGILPWLIDKIGWVISKASRLPKLESFFSIQMMFLGNTEALAVIRQQLTVL SNNRLLTFGLMSMSSISGSIIGSYLSMVPATYVFTAIPLNCLNALIIANLLNPVHVPE DEDIIYTPPKEEKKDFFSTISNSMLVGMNMVIVILAMVIGYVALTSAVNGILGVFVHG LTIQTIFAYLFSPFAFLLGLPVHDAMYVAQLMGMKLATNEFVAMLDLKNNLKSLPPHT VAVATTFLTSFANFSTVGMIYGTYNSILDGEKSTVIGRNVWKLLVSGIAVSLLSAAIV GLFVW*" /label="nupG CDS" gene 3506637..3507830 /gene="nupG" /locus_tag="BSU_39020" /old_locus_tag="BSU39020" /label="nupG gene" promotor_-10 complement(3506921..3506939) /Source="Nicolas_upshift_promotors" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3506937) /Source="Nicolas_upshifts" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3506952..3506959) /Source="Nicolas_upshift_promotors" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3507606 /Source="Nicolas_upshifts" /id="D2029" /incds=1 /nref=1 /ntot=58 /MaxReadThrough="5.88279" /MaxDrop="2.4159" /score="8.04757856" /energy="-16.6" /TU="U3082,U3083" /idTUdmin="U3082" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" downshifts 3507826 /Source="Nicolas_upshifts" /id="D2030" /incds=0 /nref=71 /ntot=204 /MaxReadThrough="2.7474" /MaxDrop="4.05925" /score="8.04757856" /energy="-16.6" /TU="NA" /idTUdmin="U3082" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3507872..3508300) /gene="yxiTc" /locus_tag="BSU_39029" /old_locus_tag="BSU39029" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (C-terminus)" /translation="KTKKQANSRALKREYQTSFSVKYNAAGKLSIQTLNYIYSGGAHG LTSVQSFNYDLKAQKRVTLDQILNTKTKVSKTRDYLYSYIKKHDVLFFSDVKKEDITL NRDTMFYFTANGIAIVFGQYDLGPYAAGIRDVQVPASIYQ*" /label="yxiTc CDS" gene complement(3507872..3508300) /gene="yxiTc" /locus_tag="BSU_39029" /old_locus_tag="BSU39029" /pseudo /label="yxiTc gene" CDS complement(3508301..3508543) /gene="yxiTn" /locus_tag="BSU_39030" /old_locus_tag="BSU39030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (N-terminus)" /db_xref="PSEUDO:CAB15929.2" /db_xref="SubtiList:BG11149" /db_xref="UniProtKB/Swiss-Prot:P42311" /translation="MKWNNMLKAAGIAVLLFSVFAYAAPSLKAVQAKTPTVSTHTYKK IKELTYPQVHHVGNAAFEKKINQELKAYMNNRIRNT*" /label="yxiTn CDS" gene complement(3508301..3508543) /gene="yxiTn" /locus_tag="BSU_39030" /old_locus_tag="BSU39030" /pseudo /label="yxiTn gene" S_feature complement(3508544..3508607) /Source="Nicolas_S_feature" /locus_tag="new_4007659_4007722_c" /HighExp="T2.30H, S6, Etha, T3.30H, S5, BT, T3.0H, T4.0H, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.942" /TUlongSig="NA" /TUlongPSig="NA" /label="S1504" promotor_-10 complement(3508596..3508611) /Source="Nicolas_upshift_promotors" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3508607) /Source="Nicolas_upshifts" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3508623..3508632) /Source="Nicolas_upshift_promotors" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3508640 /Source="Nicolas_upshifts" /id="D2031" /incds=0 /nref=10 /ntot=69 /MaxReadThrough="0.814549999999999" /MaxDrop="3.89525" /score="14.5338714" /energy="-6.9" /TU="NA" /idTUdmin="U3082" /TUdmin=814 /isTUend="FALSE" /label="downshifts" CDS complement(3508688..3508978) /gene="yxiS" /locus_tag="BSU_39040" /old_locus_tag="BSU39040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391783.2" /db_xref="EnsemblGenomes-Gn:BSU39040" /db_xref="EnsemblGenomes-Tr:CAB15930" /db_xref="SubtiList:BG11148" /db_xref="UniProtKB/Swiss-Prot:P42310" /translation="MNEKQLTEAYERDENMMILVFAQWCVNHDLDPMELYAKAYPQQK LNESLKKTMDDLVVPKHEAEHIPDQTVIAVLEMFGNTDLAQALHEAISGRKQ*" /label="yxiS CDS" gene complement(3508688..3508978) /gene="yxiS" /locus_tag="BSU_39040" /old_locus_tag="BSU39040" /label="yxiS gene" downshifts complement(3508694) /Source="Nicolas_upshifts" /id="D2032" /incds=0 /nref=168 /ntot=241 /MaxReadThrough="3.10756" /MaxDrop="6.10709" /score="16.5130207" /energy="-6.9" /TU="NA" /idTUdmin="U3086" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3509003..3509022) /Source="Nicolas_upshift_promotors" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3509020) /Source="Nicolas_upshifts" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3509028..3511088) /gene="katE" /locus_tag="BSU_39050" /old_locus_tag="BSU39050" /EC_number="1.11.1.6" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7559348, 8931328, 16151211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7559348, 8931328, 16151211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catalase 2" /protein_id="NP_391784.2" /db_xref="EnsemblGenomes-Gn:BSU39050" /db_xref="EnsemblGenomes-Tr:CAB15931" /db_xref="GOA:P42234" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024712" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG11102" /db_xref="UniProtKB/Swiss-Prot:P42234" /translation="MSDDQNKRVNEHSKDEQLEQYRTDNSGKKMTTNQGLRVSEDEHS LKAGVRGPTLMEDFHFREKMTHFDHERIPERVVHARGFGVHGFFQVYEPMTEYTRAKF LQDPSVKTPVFVRFSTVAGSKGSADTVRDARGFATKFYTEEGNYDLVGNNIPVFFIQD AIKFPDLVHAFKPEPHNEMPQAATAHDTFWDFVANNPESAHMVMWTMSDRGIPRSYRM MEGFGVHTFRFVNEQGKARFVKFHWKPVLGVHSLVWDEAQKIAGKDPDFHRRDLWETI ENGGKVEYELGVQMIDEEDEFKFDFDILDPTKLWPEELVPVKIIGKMTLNRNQDNVFA ETEQVAFHPGNVVPGIDFTNDPLLQGRLFSYTDTQLIRLGGPNFHEIPINRPVCPFHN NQYDGYHRMTINKGPVAYHKNSLQNNDPSPATAEEGGYVHYQEKVEGKKIRQRSDSFN DYYSQAKLFWNSMSPVEKQHIISAFCFEVGKVKSKDVQRQVVDVFSNVDADLAEEIAK GVGVAAPAKRKASKEILTSPALSQARTVKTASTRKVAVLAGNGFHEKELQTVLEALKQ EGITVDIISQNLGYMTSGSGQQLEASGTFLTVDSVLYDAVYAAGGLELKDNKQAMAFI REAYNHYKAIGAANEGIDLLQSSVGTTEGLGIVTAKDEPDYTAFSKAFIDAVAAHRHW DRRI*" /label="katE CDS" gene complement(3509028..3511088) /gene="katE" /locus_tag="BSU_39050" /old_locus_tag="BSU39050" /label="katE gene" promotor_-35 complement(3509036..3509043) /Source="Nicolas_upshift_promotors" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3511117..3511135) /Source="Nicolas_upshift_promotors" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3511121) /Source="Nicolas_upshifts" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3511150..3511156) /Source="Nicolas_upshift_promotors" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3511181..3511186 /Source="Nicolas_upshift_promotors" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3511200 /Source="Nicolas_upshifts" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3511202..3511220 /Source="Nicolas_upshift_promotors" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3511214..3511288 /Source="Nicolas_S_feature" /locus_tag="new_4010329_4010403" /HighExp="S6, S5, S4, S8, S7, S3, M9-stat, LoTm, BT, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1505" CDS 3511289..3512569 /gene="citH" /locus_tag="BSU_39060" /old_locus_tag="BSU39060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8892821, 11053381, 15849754, 16850406, 18556792" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8892821, 11053381, 15849754, 16850406, 18556792; Product type t : transporter" /codon_start=1 /transl_table=11 /product="secondary transporter of divalent metal ions/citrate complexes" /protein_id="NP_391785.2" /db_xref="EnsemblGenomes-Gn:BSU39060" /db_xref="EnsemblGenomes-Tr:CAB15932" /db_xref="GOA:P42308" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG11146" /db_xref="UniProtKB/Swiss-Prot:P42308" /translation="MLAILGFVMMIVFMYLIMSNRLSALIALIVVPIVFALISGFGKD LGEMMIQGVTDLAPTGIMLLFAILYFGIMIDSGLFDPLIAKILSFVKGDPLKIAVGTA VLTMTISLDGDGTTTYMITIAAMLPLYKRLGMNRLVLAGIAMLGSGVMNIIPWGGPTA RVLASLKLDTSEVFTPLIPAMIAGILWVIAVAYILGKKERKRLGVISIDHAPSSDPEA APLKRPALQWFNLLLTVALMAALITSLLPLPVLFMTAFAVALMVNYPNVKEQQKRISA HAGNALNVVSMVFAAGIFTGILSGTKMVDAMAHSLVSLIPDAMGPHLPLITAIVSMPF TFFMSNDAFYFGVLPIIAEAASAYGIDAAEIGRASLLGQPVHLLSPLVPSTYLLVGMA GVSFGDHQKFTIKWAVGTTIVMTIAALLIGIISF*" /label="citH CDS" gene 3511289..3512569 /gene="citH" /locus_tag="BSU_39060" /old_locus_tag="BSU39060" /label="citH gene" S_feature 3512570..3512709 /Source="Nicolas_S_feature" /locus_tag="new_4011685_4011824" /HighExp="S6, S5, S4, S8, S7, S3, M9-stat, BT, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.382965" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1506" downshifts 3512666 /Source="Nicolas_upshifts" /id="D2033" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="2.69139" /MaxDrop="3.50434" /score="10.8797157" /energy="-9" /TU="NA" /idTUdmin="U3088" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3512727..3513455) /gene="bglS" /locus_tag="BSU_39070" /old_locus_tag="BSU39070" /EC_number="3.2.1.73" /EC_number="3.2.1.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1369198, 3106158, 7704256, 20600285, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1369198, 3106158, 7704256, 20600285, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-beta-1,3-1,4 glucanase" /protein_id="NP_391786.1" /db_xref="EnsemblGenomes-Gn:BSU39070" /db_xref="EnsemblGenomes-Tr:CAB15943" /db_xref="GOA:P04957" /db_xref="InterPro:IPR000757" /db_xref="InterPro:IPR008263" /db_xref="InterPro:IPR008264" /db_xref="InterPro:IPR013320" /db_xref="PDB:3O5S" /db_xref="SubtiList:BG10476" /db_xref="UniProtKB/Swiss-Prot:P04957" /translation="MPYLKRVLLLLVTGLFMSLFAVTATASAQTGGSFFDPFNGYNSG FWQKADGYSNGNMFNCTWRANNVSMTSLGEMRLALTSPAYNKFDCGENRSVQTYGYGL YEVRMKPAKNTGIVSSFFTYTGPTDGTPWDEIDIEFLGKDTTKVQFNYYTNGAGNHEK IVDLGFDAANAYHTYAFDWQPNSIKWYVDGQLKHTATNQIPTTPGKIMMNLWNGTGVD EWLGSYNGVNPLYAHYDWVRYTKK*" /label="bglS CDS" gene complement(3512727..3513455) /gene="bglS" /locus_tag="BSU_39070" /old_locus_tag="BSU39070" /label="bglS gene" downshifts complement(3512744) /Source="Nicolas_upshifts" /id="D2034" /incds=0 /nref=64 /ntot=139 /MaxReadThrough="1.52649" /MaxDrop="6.38109" /score="-8.35070051" /energy="-16.3" /TU="NA" /idTUdmin="U3089" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3513486..3513505) /Source="Nicolas_upshift_promotors" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3513497) /Source="Nicolas_upshifts" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3513519..3513526) /Source="Nicolas_upshift_promotors" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3513643..3513750) /Source="Nicolas_S_feature" /locus_tag="new_4012758_4012865_c" /HighExp="Sw, LPhT, T0.30H, M0t90, M9-stat, M40t90, Lbtran, Lbstat, S2, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1507" downshifts complement(3513686) /Source="Nicolas_upshifts" /id="D2035" /incds=0 /nref=21 /ntot=184 /MaxReadThrough="3.35114" /MaxDrop="4.38508" /score="-8.35070051" /energy="-16.3" /TU="U3090,U3091" /idTUdmin="U3091" /TUdmin="-174" /isTUend="FALSE" /label="downshifts" CDS complement(3513751..3514584) /gene="licT" /locus_tag="BSU_39080" /old_locus_tag="BSU39080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11447120, 11580842, 11733988, 12169607, 15699035, 21278164, 23475962, 28235843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11447120, 11580842, 11733988, 12169607, 15699035, 21278164, 23475962, 28235843; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator (BglG family)" /protein_id="NP_391787.2" /db_xref="EnsemblGenomes-Gn:BSU39080" /db_xref="EnsemblGenomes-Tr:CAB15944" /db_xref="GOA:P39805" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:1H99" /db_xref="PDB:1L1C" /db_xref="PDB:1TLV" /db_xref="SubtiList:BG10474" /db_xref="UniProtKB/Swiss-Prot:P39805" /translation="MKIAKVINNNVISVVNEQGKELVVMGRGLAFQKKSGDDVDEARI EKVFTLDNKDVSEKFKTLLYDIPIECMEVSEEIISYAKLQLGKKLNDSIYVSLTDHIN FAIQRNQKGLDIKNALLWETKRLYKDEFAIGKEALVMVKNKTGVSLPEDEAGFIALHI VNAELNEEMPNIINITKVMQEILSIVKYHFKIEFNEESLHYYRFVTHLKFFAQRLFNG THMESQDDFLLDTVKEKYHRAYECTKKIQTYIEREYEHKLTSDELLYLTIHIERVVKQ A*" /label="licT CDS" gene complement(3513751..3514584) /gene="licT" /locus_tag="BSU_39080" /old_locus_tag="BSU39080" /label="licT gene" promotor_-10 complement(3514615..3514634) /Source="Nicolas_upshift_promotors" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3514634) /Source="Nicolas_upshifts" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3514648..3514655) /Source="Nicolas_upshift_promotors" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3514680..3515360) /gene="yxiP" /locus_tag="BSU_39090" /old_locus_tag="BSU39090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391788.1" /db_xref="EnsemblGenomes-Gn:BSU39090" /db_xref="EnsemblGenomes-Tr:CAB15945" /db_xref="SubtiList:BG11145" /db_xref="UniProtKB/Swiss-Prot:P42307" /translation="MRRIGLCISLLVTVLVMSACESEGEAQMFADCDQKTVKQTAAKP MSSKKKQDFQALASDRQLAIVFSSMIQVSEAFDYGIGNPEYFVRISMTEEEADIAKEN LESIKLENKSLKKQNSEAVALLQKTRNQDMSRIEIQQLTENRAGFFETADSMIKLINQ VTPKNAKKTRQQLDQLKKQYTQYSAESIKIMNSIVKKQKADKASFERHLEALLQKQPG QQVRSELY*" /label="yxiP CDS" gene complement(3514680..3515360) /gene="yxiP" /locus_tag="BSU_39090" /old_locus_tag="BSU39090" /label="yxiP gene" promotor_-10 complement(3515407..3515426) /Source="Nicolas_upshift_promotors" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="promotor_-10" upshifts complement(3515416) /Source="Nicolas_upshifts" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="upshifts" promotor_-35 complement(3515440..3515447) /Source="Nicolas_upshift_promotors" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="promotor_-35" promotor_-35 3515508..3515511 /Source="Nicolas_upshift_promotors" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3515526..3515545 /Source="Nicolas_upshift_promotors" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3515526 /Source="Nicolas_upshifts" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="upshifts" CDS 3515567..3516853 /gene="yxiO" /locus_tag="BSU_39100" /old_locus_tag="BSU39100" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12583894, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391789.1" /db_xref="EnsemblGenomes-Gn:BSU39100" /db_xref="EnsemblGenomes-Tr:CAB15946" /db_xref="GOA:P42306" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR024671" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11144" /db_xref="UniProtKB/Swiss-Prot:P42306" /translation="MMKRFTKQENSWVLYDWANSAYSIVVTTAVFPLFYKSAAAESGV SAAQSTAYLGYTIAISTFILAMLGPILGTIADYEGCKKKFFGFFVSAGVASTAMLAFI PSEHWLLLLLFYTVSAIGFSGANVFYDAFLVDVTPEKRMNLVSARGFGLGYIGSTIPF IISIAVILLAQAETIPVSVSAASQLSFFITAAWWGLFTIPMIKHVHQRYYIKKEPHIV INSFKRLGQTMKRIRQYRALFLFLLAYFFYIDGVGTIITMSTSYGSDLGIGSSSLLII LFVTQVVAAPFSIIYGKLAERFTGKTMLYVGIVIYMIVCVYAYFMETTLDFWILAMLV ATSQGGIQALSRSYFAKLVPKRHANEFFGFYNIFGKFASIMGPLLIAVTAQLTGKSST AVFSLIILFVIGIVILAFVPEETSTDVSQQQNDLPL*" /label="yxiO CDS" gene 3515567..3516853 /gene="yxiO" /locus_tag="BSU_39100" /old_locus_tag="BSU39100" /label="yxiO gene" promotor_-10 complement(3516298..3516316) /Source="Nicolas_upshift_promotors" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3516306) /Source="Nicolas_upshifts" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3516330..3516337) /Source="Nicolas_upshift_promotors" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3516824 /Source="Nicolas_upshifts" /id="D2036" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="2.50578" /MaxDrop="3.06646" /score="-7.45683354" /energy="-16.7" /TU="NA" /idTUdmin="U3092" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3516872..3518311) /gene="deaD" /locus_tag="BSU_39110" /old_locus_tag="BSU39110" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10481020, 16118224, 16611943, 17142894, 17229151, 17951299, 19839642, 20691700, 26755693" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10481020, 16118224, 16611943, 17142894, 17229151, 17951299, 19839642, 20691700, 26755693; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase for 23S ribosomal RNAmaturation" /protein_id="NP_391790.2" /db_xref="EnsemblGenomes-Gn:BSU39110" /db_xref="EnsemblGenomes-Tr:CAB15947" /db_xref="GOA:P42305" /db_xref="InterPro:IPR000629" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR005580" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028619" /db_xref="PDB:2G0C" /db_xref="PDB:2HJV" /db_xref="PDB:3MOJ" /db_xref="SubtiList:BG11143" /db_xref="UniProtKB/Swiss-Prot:P42305" /translation="MSHFKNYQISHDILRALEGLGYTEPTKVQQSVIPAALERKDLVV KSQTGSGKTASFGIPLCELANWDENKPQALILTPTRELAVQVKEDITNIGRFKRIKAT AVFGKSSFDKQKAELKQKSHIVVGTPGRVLDHIEKGTLPLDRLSYLVIDEADEMLNMG FIEQVEAIIKHLPTERTTMLFSATLPQDIEKLSRQYMQNPEHIEVKAAGLTTRNIEHA VIQVREENKFSLLKDVLMTENPDSCIIFCRTKEHVNQLTDELDDLGYPCDKIHGGMIQ EDRFDVMNEFKRGEYRYLVATDVAARGIDIENISLVINYDLPLEKESYVHRTGRTGRA GNKGKAISFVTAFEKRFLADIEEYIGFEIQKIEAPSQEEVARKKPEFLAKLNDRPESK KDKSEELNKDIMKLYFNGGKKKKIRAVDFVGTIAKIDGVSADDIGIITIMDNASYVEI LNGKGPHVLKVMKNTTVKGKQLKVNKANK*" /label="deaD CDS" gene complement(3516872..3518311) /gene="deaD" /locus_tag="BSU_39110" /old_locus_tag="BSU39110" /label="deaD gene" downshifts complement(3516895) /Source="Nicolas_upshifts" /id="D2037" /incds=0 /nref=200 /ntot=269 /MaxReadThrough="1.50578" /MaxDrop="5.83238" /score="3.28924902" /energy="-18.2" /TU="NA" /idTUdmin="U3095" /TUdmin=5 /isTUend="TRUE" /label="downshifts" misc_feature complement(3518335..3518354) /Source="Nicolas_upshift_promotors" /id="U3094" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.496503496503497" /psig="0.56943056943057" /xcortree=1449 /SigmaFactorBS="agggaatcgctggcttttaatacatcatttttcgacaaaaca catatgccttggtcaaTTAGAGTATAATGAGAACATctgcaagagacaggagtttata c" /listShort="deaD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3518352) /Source="Nicolas_upshifts" /id="U3094" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.496503496503497" /psig="0.56943056943057" /xcortree=1449 /SigmaFactorBS="agggaatcgctggcttttaatacatcatttttcgacaaaaca catatgccttggtcaaTTAGAGTATAATGAGAACATctgcaagagacaggagtttata c" /listShort="deaD" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3518393..3519541) /gene="yxiM" /locus_tag="BSU_39120" /old_locus_tag="BSU39120" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10746760, 25394512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="esterase (lipoprotein)" /protein_id="NP_391791.2" /db_xref="EnsemblGenomes-Gn:BSU39120" /db_xref="EnsemblGenomes-Tr:CAB15948" /db_xref="GOA:P42304" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="PDB:2O14" /db_xref="SubtiList:BG11142" /db_xref="UniProtKB/Swiss-Prot:P42304" /translation="MKKWMAAVFVMMLMLCFGGIENVKAAEPKVYQFDFGSGSMEPGY IGVRASDRYDRSKGYGFQTPENMRDVAASGAGVKSDAVQFLAYGTKSNNTFNVDLPNG LYEVKVTLGNTARASVAAEGVFQVINMTGDGAEDTFQIPVTDGQLNLLVTEGKAGTAF TLSALKIKKLSDQPVTNRTIYVGGDSTVCNYYPLNSSKQAGWGQMLPHYIDKHTFQVR NMASGGQIARGFRNDGQLEAILKYIKPGDYFMLQLGINDTNPKHKESEAEFKEVMRDM IRQVKAKGADVILSTPQGRATDFTSEGIHSSVNRWYRASILALAEEEKTYLIDLNVLS SAYFTSIGPERTLGLYMDGDTLHPNRAGADALARLAVQELKRQGIAGF*" /label="yxiM CDS" gene complement(3518393..3519541) /gene="yxiM" /locus_tag="BSU_39120" /old_locus_tag="BSU39120" /label="yxiM gene" promotor_-10 complement(3519568..3519584) /Source="Nicolas_upshift_promotors" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3519584) /Source="Nicolas_upshifts" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3519586..3519670) /Source="Nicolas_S_feature" /locus_tag="new_4018701_4018785_c" /HighExp="T3.30H, T4.0H, T2.30H, T3.0H, T2.0H, T-3.40H, T5.0H, T-2.40H, Lbexp, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1508" promotor_-35 complement(3519599..3519604) /Source="Nicolas_upshift_promotors" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3519671..3519859) /gene="yxzI" /locus_tag="BSU_39129" /old_locus_tag="BSU39129" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52710.1" /translation="MRFENISASKLDDLESIDSVALEIVPTDDQWERLRYYVYDEENQ ISFYCGGWDVIKCDKKSH*" /label="yxzI CDS" gene complement(3519671..3519859) /gene="yxzI" /locus_tag="BSU_39129" /old_locus_tag="BSU39129" /pseudo /label="yxzI gene" CDS complement(3519890..3520021) /gene="yxzJ" /locus_tag="BSU_39139" /old_locus_tag="BSU39139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097796.1" /db_xref="EnsemblGenomes-Gn:BSU39139" /db_xref="EnsemblGenomes-Tr:CAX52711" /db_xref="UniProtKB/Swiss-Prot:C0H3T5" /translation="MNITQYEKLKQHLSDEDTGPFTLNEFSFYMKEDDRYIHIPVFE* " /label="yxzJ CDS" gene complement(3519890..3520021) /gene="yxzJ" /locus_tag="BSU_39139" /old_locus_tag="BSU39139" /label="yxzJ gene" CDS complement(3520033..3520494) /gene="yxiK" /locus_tag="BSU_39140" /old_locus_tag="BSU39140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type f: factor" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391793.1" /db_xref="EnsemblGenomes-Gn:BSU39140" /db_xref="EnsemblGenomes-Tr:CAB15950" /db_xref="SubtiList:BG11140" /db_xref="UniProtKB/Swiss-Prot:P42302" /translation="MEITSISSIGNLDMIELKPDQTVMACELEDAESFYRFWAGLAYD RIMIQVITTGSFIEDLSEYFEGHAYKVTKLAKREFHFQSILQEADRDIADFLFLLASI NDDVFLITDPQPDKSYFSEGKLQCLTDSGERIIWFEYDAVDIYMIGGESYK*" /label="yxiK CDS" gene complement(3520033..3520494) /gene="yxiK" /locus_tag="BSU_39140" /old_locus_tag="BSU39140" /label="yxiK gene" CDS complement(3520510..3520806) /gene="yxiJ" /locus_tag="BSU_39150" /old_locus_tag="BSU39150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391794.1" /db_xref="EnsemblGenomes-Gn:BSU39150" /db_xref="EnsemblGenomes-Tr:CAB15951" /db_xref="InterPro:IPR025551" /db_xref="SubtiList:BG11139" /db_xref="UniProtKB/Swiss-Prot:P42320" /translation="MLQKLRKRQRELEEKQYPDELYGFEAEIYEFFMLVAGSLDYVLA NKRIPRHQRRSLEKSFFELYPDILPDMIKNDKDLYHHILLYEQVRQEICVALSN*" /label="yxiJ CDS" gene complement(3520510..3520806) /gene="yxiJ" /locus_tag="BSU_39150" /old_locus_tag="BSU39150" /label="yxiJ gene" CDS complement(3520834..3521322) /gene="yxiI" /locus_tag="BSU_39160" /old_locus_tag="BSU39160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391795.1" /db_xref="EnsemblGenomes-Gn:BSU39160" /db_xref="EnsemblGenomes-Tr:CAB15952" /db_xref="InterPro:IPR020323" /db_xref="SubtiList:BG11138" /db_xref="UniProtKB/Swiss-Prot:P42301" /translation="MMNWRALSQTKQDRIWSEVNKIIKWKPGSRCHHIIPPDPYRVFD ISSAMSSKAGHNDVSGVLSDLETSILKAFQLGTGKNDVMYALDWQHDGYTFSPHQAMP KDEFGEWPVPVFPNGDYYFFFHQDFSWGLLGDPWKCAITVFGEELLEAIDNDPPILFR NK*" /label="yxiI CDS" gene complement(3520834..3521322) /gene="yxiI" /locus_tag="BSU_39160" /old_locus_tag="BSU39160" /label="yxiI gene" CDS complement(3521340..3521792) /gene="yxzG" /locus_tag="BSU_39170" /old_locus_tag="BSU39170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_391796.1" /db_xref="EnsemblGenomes-Gn:BSU39170" /db_xref="EnsemblGenomes-Tr:CAB15953" /db_xref="SubtiList:BG14170" /db_xref="UniProtKB/Swiss-Prot:O32285" /translation="MWCFTLDGQQKEIHIDRKLEEMDAPAVDDCYGLAEKNGLIYMLY YGDAVIAAFDETVVRRVWILSDKEPDSEAFDQLAISEEGFLVGTFNCYSADLKSSLYL ISADVSQEMEEITCCDSNGEGLDVQQLKLTSYAVYAVASSGVYKQDIQ*" /label="yxzG CDS" gene complement(3521340..3521792) /gene="yxzG" /locus_tag="BSU_39170" /old_locus_tag="BSU39170" /label="yxzG gene" S_feature complement(3521793..3521861) /Source="Nicolas_S_feature" /locus_tag="new_4020908_4020976_c" /HighExp="T4.0H, T3.30H, T3.0H, T2.30H, T2.0H, T-3.40H, T5.0H, T-2.40H, T-4.40H, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.19384199999999999" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1509" CDS complement(3521862..3522191) /gene="yxiH" /locus_tag="BSU_39180" /old_locus_tag="BSU39180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391797.1" /db_xref="EnsemblGenomes-Gn:BSU39180" /db_xref="EnsemblGenomes-Tr:CAB15954" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG11137" /db_xref="UniProtKB/Swiss-Prot:P42300" /translation="MKKLKLNKIINENTQDCFFHADPQGRVYIGKGLKGGITITIYDP SGDVRDFRVKEQISYSDILLFQQCADGYVFVYYESYEPKVKVFSEEGRVKSVFHLPSG VSCCLLD*" /label="yxiH CDS" gene complement(3521862..3522191) /gene="yxiH" /locus_tag="BSU_39180" /old_locus_tag="BSU39180" /label="yxiH gene" S_feature complement(3522192..3522313) /Source="Nicolas_S_feature" /locus_tag="new_4021307_4021428_c" /HighExp="T3.30H, T4.0H, T3.0H, T2.30H, T-4.40H, T-3.40H, LBGexp, T-2.40H, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1510" CDS complement(3522314..3522730) /gene="yxiG" /locus_tag="BSU_39190" /old_locus_tag="BSU39190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391798.1" /db_xref="EnsemblGenomes-Gn:BSU39190" /db_xref="EnsemblGenomes-Tr:CAB15955" /db_xref="SubtiList:BG11136" /db_xref="UniProtKB/Swiss-Prot:P42299" /translation="MTMYQTINEWVDYIDKGCSVLHLDFNVFKKELSLDIKVFEDEGE YTHKISFQNVASAYYSADVGDMRLEKIDPEEYNWQVFEMSYHPEGIGNLSNSIIPEYQ SNANFLIDMNRMLIAIEAETVRFDDQSFYAYQLNTK*" /label="yxiG CDS" gene complement(3522314..3522730) /gene="yxiG" /locus_tag="BSU_39190" /old_locus_tag="BSU39190" /label="yxiG gene" CDS complement(3522781..3523149) /gene="yxzC" /locus_tag="BSU_39200" /old_locus_tag="BSU39200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_391799.1" /db_xref="EnsemblGenomes-Gn:BSU39200" /db_xref="EnsemblGenomes-Tr:CAB15956" /db_xref="SubtiList:BG14167" /db_xref="UniProtKB/Swiss-Prot:O32286" /translation="MVDWKPFGTYLLRKKLQYLNISTVLCILIKNHLVLEYVVIKLSE TNLIECINKIKSVLNGQTTREEVSDWAGTYVYADDPEVEDDRVWDMLILLSGIDLKDS SETYLHSTDDLNDWIKQYTE*" /label="yxzC CDS" gene complement(3522781..3523149) /gene="yxzC" /locus_tag="BSU_39200" /old_locus_tag="BSU39200" /label="yxzC gene" CDS complement(3523143..3523613) /gene="yxiF" /locus_tag="BSU_39210" /old_locus_tag="BSU39210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391800.1" /db_xref="EnsemblGenomes-Gn:BSU39210" /db_xref="EnsemblGenomes-Tr:CAB15957" /db_xref="SubtiList:BG11135" /db_xref="UniProtKB/Swiss-Prot:P42298" /translation="MQKRLIEKLAENKRRLLMSEIKEKLVPCAERGFTYRFADLAQSR QLLELVLSNSIPANTREVDALEKTEAKQLIWKISQSYVAYDDRDVLLFHQYSSEIGAL VCSFGKCLEHLDCLLECIEFDEGILNHSFILVEPKCQFGLCILHTEYGCELVYW*" /label="yxiF CDS" gene complement(3523143..3523613) /gene="yxiF" /locus_tag="BSU_39210" /old_locus_tag="BSU39210" /label="yxiF gene" S_feature complement(3523614..3523938) /Source="Nicolas_S_feature" /locus_tag="new_4022729_4023053_c" /HighExp="T3.30H, T-2.40H, T2.30H, T3.0H, T4.0H, SMMPr, MG 120, C90, T2.0H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1511" CDS complement(3523939..3524367) /gene="wapI" /locus_tag="BSU_39220" /old_locus_tag="BSU39220" /experiment="publication(s) with functional evidences, PMID:1529529, 16306698, 19763274, 23572593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1529529, 16306698, 19763274, 23572593; Product type f: factor" /codon_start=1 /transl_table=11 /product="antitoxin of WapA tRNase" /protein_id="NP_391801.1" /db_xref="EnsemblGenomes-Gn:BSU39220" /db_xref="EnsemblGenomes-Tr:CAB15958" /db_xref="SubtiList:BG10798" /db_xref="UniProtKB/Swiss-Prot:Q07836" /translation="MAKIKDDCIELELTPRRYQELDDDPFILSVFELLENKKAVVRDF SAVLLESEYKVLISGIETMIKGNQDSISLETIEPFLFLSIDQENGNYRIKIKIIFDDY KESKSNSNLFEINCNEEKLESFVTALKLNLENTKNPSKLP*" /label="wapI CDS" gene complement(3523939..3524367) /gene="wapI" /locus_tag="BSU_39220" /old_locus_tag="BSU39220" /label="wapI gene" CDS complement(3524429..3531433) /gene="wapA" /locus_tag="BSU_39230" /old_locus_tag="BSU39230" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8316082, 9537385, 16306698, 16849803, 21636651, 23199363, 23572593, 23944997, 25666134, 28827522" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8316082, 9537385, 16306698, 16849803, 21636651, 23199363, 23572593, 23944997, 25666134, 28827522; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cell wall-associated tRNA nuclease precursor; intercellular growth inhibitor" /protein_id="NP_391802.2" /db_xref="EnsemblGenomes-Gn:BSU39230" /db_xref="EnsemblGenomes-Tr:CAB15959" /db_xref="GOA:Q07833" /db_xref="InterPro:IPR006530" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR022385" /db_xref="InterPro:IPR031325" /db_xref="SubtiList:BG10797" /db_xref="UniProtKB/Swiss-Prot:Q07833" /translation="MKKRKRRNFKRFIAAFLVLALMISLVPADVLAKSTEEENGNRIA ADDPEETLQKEQTEEAVPFDPKDINKEGEITSERTENTKLYYEGDGVYKQEVYLDPIH TKETPDADWEDISPELKESTSKQVETENAILNSDFQKQMKNGLYATFEHNDHKVTYSL AEAKGPNKTSLTPKDTSADYKTDSNEIVYPDVFPNIDLQTFTFNENIKEDLVLHQYNG YNTFTFQLKTDLQAKEQEDGSIDFSDEKGKVVFSVPKPFMTDSKLDELSGEVERSDKV SYKLEKNEEGYLLHLTADENWLKDPERVYPVSIDPSTSLSVSSDTFVMSAYPTTNYSA SSQKWDANLKAYVLKTGYYDKTTGTNYAFMKFNNLKPIQNMTVTKATLKTYVAHSYYG TKATGLWLDTVNSNYDNAKVTWNTKPASKNIGKADVHKGQWASYDVTAAVKSWNSGGA NYGFKLHTNGNGKEYWKKLISSANSANKPYIEVTYTIPKGNTPTIKAYHNGDSTGYFD ISWKKVEGAKGYKVWIYNGKEYQAISAGNVTSWSTKGKKIWPTSAEIASKRYKLHLDG KDGAELALDPSPVYKNSGGSYATSKNYWIGVSAIFDQGEGAMSAPAKPVIPNVGKAQA PSAKGYNNGNATGYFDLSWKAVSGATGYKVQVFNGKGFETLDLGNQTSWTTKGKKIWP TSAEIKAGKYALHLKDGSGAELPINPGPTYKNAGGDGAKRNYSFKIIAYNKDGEAIAS PAATPALPDIARPKNVTGYLYTNTKSSQTGYVNLIWEKVQNAKGYKVNIYNGKEYQSF DVGDADHWTTQNKNIWPTSEEIKAGSYKLHTDGKGGELALDPSPVYNNANGNYKGKKN YSFTLVAYDANGETIPTAPFNPTFHEGAEFLGTEEYWSIIDIPSGQLNGATGNVIVNE EDLSIDGRGPGLGLSRTYNSLDSSDHLFGQGWYADAETSVISTDGGAMYIDEDATTHR FTKKADGTYQPPTGVYLELTETADQFILKTKDQTNAYFNKKGGKLQKVVDGHNNATVY TYNDKNQLTAITDASGRKLTFTYDENGHVTSITGPKNKKVTYSYENDLLKKVTDTDGT VTSYDYDSEGRLVKQYSANSTEAKPVFTEYQYSGHRLEKAINAKKETYVYSYDADKKT LLMTQPNGRKVQYGYNEAGNPIQVIDDAEGLKITTNTKYEGNNVVEDVDPNDVGTGKA TESYQYDKDGNVTSVKDAYGTETYEYNKNNDVTKMKDTEGNVTDIAYDGLDAVSETDQ SGKSSSAAVYDKYGNQIQSSKDLSASTNILKDGSFEAQKSGWNLTASKDSGKISVIAD KSGVLSGSKALEVLSQSTSAGTDHGYSSATQTVELEPNTTYTLSGKIKTDLAKSRAYF NIDLRDKDQKRIQWIHNEYSALAGKNDWTKRQITFTTPANAGKAVVYMEVDHKDKDGK GKAWFDEVQLEKGEVSSSYNPVQNSSFTSATENWNVSGASVDSEEGFNDDVSLKAART SASQAGSVTKQTVVLGQSANDKPVYLTLTGMSKASSVKFTDEKDYSLQANVTYADGST GIYNAKFPSGTQEWNRAAVVIPKTKPINKVDISILFQKSATGTVWFDDIRLIEGSLLT KSTYDSNGNYVTKEEDELGYATSTDYDETGKKTSETDAKGEKTTYTYDQADQLTNMTL SNGTSILHSYDKEGNEVSKTIRAGADQTYKFEYDVMGKLVKTTDPLGNVLASEYDANS NLTKTISPNGNEVSLSYDGTDRVKSKSYNGTEKYIFTYDKNGNETSVVNKEQNTTKKR TFDNKNRLTELTDRGGSQTWTYPSDSDKLKTFSWIHGDQKGTNQFTYNKLDQMIEMKD STSSYSFDYDENGNVQTFITGNGGGTSFSYDERNLVSSLHIGDKNGGDILTESYEYDA NGNRTTINSSASGKVQYEYGKLNQLVKETHEDGTVIEYTYDGFGNRKTVTTIKDGSSK TVNASFNIMNQLTKVNDESISYDKNGNRTSDGKFTYTWDAEDNLTAVTKKGEDKPFAT YKYDEKGNRIQKTVNGKVTNYFYDGDSLNVLYETDADNNVTKSYTYGDSGQLLSYTEN GKKYFYHYNAHGDIIAISDSTGKTVAKYQYDAWGNPTKTEASDEVKDNRYRYAGYQYD EETGLYYLMARYYEPRNGVFLSLDPDPGSDGDSLDQNGYAYGNNNPVMNVDPDGHWVW LVVNAGFAAYDGYKAYKSGKGWKGAAWAAASNFGPGKIFKGASRAYKFTKKAVKITGH TRHGLNQSIGRNGGRGVNLRAKLNAVRSPKKVIKQPNGATKYVGKKATVVLNKRGKVI TAYGSSRAKGSKHVFHTHGKGNKSKRRR*" /label="wapA CDS" gene complement(3524429..3531433) /gene="wapA" /locus_tag="BSU_39230" /old_locus_tag="BSU39230" /label="wapA gene" misc_feature 3531440..3531454 /Source="Nicolas_upshift_promotors" /id="U3096" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.896103896103896" /psig="0.0919080919080919" /xcortree=301 /SigmaFactorBS="caatgaaccttttaaagtttcgcctctttctttttttcattt cctcTCTCCTTTTGTAATAaaagtaatatttactcaataatcttaactagactgaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3531454 /Source="Nicolas_upshifts" /id="U3096" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.896103896103896" /psig="0.0919080919080919" /xcortree=301 /SigmaFactorBS="caatgaaccttttaaagtttcgcctctttctttttttcattt cctcTCTCCTTTTGTAATAaaagtaatatttactcaataatcttaactagactgaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3531464..3531483) /Source="Nicolas_upshift_promotors" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3531479) /Source="Nicolas_upshifts" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3531498..3531505) /Source="Nicolas_upshift_promotors" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3531595..3532530) /gene="yxxF" /locus_tag="BSU_39240" /old_locus_tag="BSU39240" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391803.1" /db_xref="EnsemblGenomes-Gn:BSU39240" /db_xref="EnsemblGenomes-Tr:CAB15960" /db_xref="GOA:Q07835" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG10796" /db_xref="UniProtKB/Swiss-Prot:Q07835" /translation="MQQDPSISSKQKSTAVIKMVISMVIFGSIGFFSEHTNLPSFELV FVRCLCATLFLGFCWLASGQYKTEKWSKRDVLQTLACGFFLVFNWVFLFKSFEETSVT IAISVYHLAPVLVLLLGSFFYREKLNVISVSSIIICFLGTALISGINGSTSLTQLMGS GIIWAVLAALFYAFTTLLGKGIHNLSPYTTTFLQTGLGVIILIPFIHFGAFADLSQGN WIMVVSTGIIHTGIVYLLFFDSLRFLSTKFISIIVFLDPAVAIVLDTVFTGFRPDLYQ TLGIVMIFAGMALTLVRRQGKANVTAEGTDIEQIQ*" /label="yxxF CDS" gene complement(3531595..3532530) /gene="yxxF" /locus_tag="BSU_39240" /old_locus_tag="BSU39240" /label="yxxF gene" downshifts complement(3531816) /Source="Nicolas_upshifts" /id="D2038" /incds=1 /nref=1 /ntot=153 /MaxReadThrough="1.33481" /MaxDrop="2.42407" /score="29.0290332" /energy="-5.9" /TU="NA" /idTUdmin="U3098" /TUdmin=22 /isTUend="TRUE" /label="downshifts" S_feature complement(3532531..3532651) /Source="Nicolas_S_feature" /locus_tag="new_4031646_4031766_c" /HighExp="T3.0H, T1.0H, T3.30H, LBGstat, T1.30H, T0.30H, T4.0H, M9-stat, T2.30H, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="Sig-" /TUlongPSig="0.196" /label="S1512" CDS complement(3532682..3533128) /gene="yxiE" /locus_tag="BSU_39250" /old_locus_tag="BSU39250" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10913081, 12644671, 17210127" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 12644671, 17210127; Product type f: factor" /codon_start=1 /transl_table=11 /product="phosphate starvation protein (universal stress protein A family)" /protein_id="NP_391804.1" /db_xref="EnsemblGenomes-Gn:BSU39250" /db_xref="EnsemblGenomes-Tr:CAB15961" /db_xref="GOA:P42297" /db_xref="InterPro:IPR006015" /db_xref="InterPro:IPR006016" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11134" /db_xref="UniProtKB/Swiss-Prot:P42297" /translation="MFNKMLVAIDGSDMSAKALDAAVHLAKEQQAELSILHVGREAVV TTSSLTGIVYVPEHFIDEIRNEVKKEGLKILENAKEKAAEKGVQAETIYANGEPAHEI LNHAKEKGVSLIVVGSRGISGLKEMMLGSVSHKVSQLSTCPVLIVR*" /label="yxiE CDS" gene complement(3532682..3533128) /gene="yxiE" /locus_tag="BSU_39250" /old_locus_tag="BSU39250" /label="yxiE gene" downshifts complement(3532696) /Source="Nicolas_upshifts" /id="D2039" /incds=0 /nref=22 /ntot=144 /MaxReadThrough="4.33955" /MaxDrop="6.75522" /score="45.6082379" /energy="-8.4" /TU="U3098" /idTUdmin="U3099" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3533165..3533184) /Source="Nicolas_upshift_promotors" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3533172) /Source="Nicolas_upshifts" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3533198..3533205) /Source="Nicolas_upshift_promotors" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3533231..3534640) /gene="bglH" /locus_tag="BSU_39260" /old_locus_tag="BSU39260" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14652714, 15139916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652714, 15139916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-phospho-beta-d-glucosidase" /protein_id="NP_391805.2" /db_xref="EnsemblGenomes-Gn:BSU39260" /db_xref="EnsemblGenomes-Tr:CAB15962" /db_xref="GOA:P40740" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG10935" /db_xref="UniProtKB/Swiss-Prot:P40740" /translation="MSSNEKRFPEGFLWGGAVAANQVEGAYNEGGKGLSTADVSPNGI MSPFDESMTSLNLYHNGIDFYHRYKEDIALFAEMGFKAFRTSIAWTRIFPNGDEEEPN EEGLRFYDDLFDELLKHHIEPVVTISHYEMPLGLVKNYGGWKNRKVIEFYERYAKTVF KRYQHKVKYWMTFNEINVVLHAPFTGGGLVFEEGENKLNAMYQAAHHQFVASALAVKA GHDIIPDSKIGCMIAATTTYPMTSKPEDVFAAMENERKTLFFSDVQARGAYPGYMKRY LAENNIEIEMAEGDEELLKEHTVDYIGFSYYMSMAASTDPEELAKSGGNLLGGVKNPY LKSSEWGWQIDPKGLRITLNTLYDRYQKPLFIVENGLGAVDKVEEDGTIQDDYRINYL RDHLIEAREAIADGVELIGYTSWGPIDLVSASTAEMKKRYGFIYVDRDNEGNGTFNRI KKKSFNWYQQVIATNGESL*" /label="bglH CDS" gene complement(3533231..3534640) /gene="bglH" /locus_tag="BSU_39260" /old_locus_tag="BSU39260" /label="bglH gene" CDS complement(3534663..3536492) /gene="bglP" /locus_tag="BSU_39270" /old_locus_tag="BSU39270" /EC_number="2.7.1.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17074746, 8626332" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17074746, 8626332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) beta-glucoside-specific enzyme IIBCA component" /protein_id="NP_391806.2" /db_xref="EnsemblGenomes-Gn:BSU39270" /db_xref="EnsemblGenomes-Tr:CAB15963" /db_xref="GOA:P40739" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011297" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10934" /db_xref="UniProtKB/Swiss-Prot:P40739" /translation="MDYDKLSKDILQLVGGEENVQRVIHCMTRLRFNLHDNAKADRSQ LEQLPGVMGTNISGEQFQIIIGNDVPKVYQAIVRHSNLSDEKSAGSSSQKKNVLSAVF DVISGVFTPILPAIAGAGMIKGLVALAVTFGWMAEKSQVHVILTAVGDGAFYFLPLLL AMSAARKFGSNPYVAAAIAAAILHPDLTALLGAGKPISFIGLPVTAATYSSTVIPILL SIWIASYVEKWIDRFTHASLKLIVVPTFTLLIVVPLTLITVGPLGAILGEYLSSGVNY LFDHAGLVAMILLAGTFSLIIMTGMHYAFVPIMINNIAQNGHDYLLPAMFLANMGQAG ASFAVFLRSRNKKFKSLALTTSITALMGITEPAMYGVNMRLKKPFAAALIGGAAGGAF YGMTGVASYIVGGNAGLPSIPVFIGPTFIYAMIGLVIAFAAGTAAAYLLGFEDVPSDG SQQPAVHEGSREIIHSPIKGEVKALSEVKDGVFSAGVMGKGFAIEPEEGEVVSPVRGS VTTIFKTKHAIGITSDQGAEILIHIGLDTVKLEGQWFTAHIKEGDKVAPGDPLVSFDL EQIKAAGYDVITPVIVTNTDQYSFSPVKEIGKVQPKEALLALS*" /label="bglP CDS" gene complement(3534663..3536492) /gene="bglP" /locus_tag="BSU_39270" /old_locus_tag="BSU39270" /label="bglP gene" promotor_no_box complement(3536484..3536584) /Source="Nicolas_upshift_promotors" /id="U3099" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.195804195804196" /xcortree=1562 /SigmaFactorBS="ttaggaggtgatgcagcatttgatacaaaaaaagctggtgaa aggcggccacctttcatccagcagtccccccataaaaaggaggtatacacatggatta t" /listShort="bglP, bglH, yxiE" /listLong="S1512, yxxF" /label="promotor_no_box" upshifts complement(3536524) /Source="Nicolas_upshifts" /id="U3099" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.195804195804196" /xcortree=1562 /SigmaFactorBS="ttaggaggtgatgcagcatttgatacaaaaaaagctggtgaa aggcggccacctttcatccagcagtccccccataaaaaggaggtatacacatggatta t" /listShort="bglP, bglH, yxiE" /listLong="S1512, yxxF" /label="upshifts" S_feature complement(3536526..3536718) /Source="Nicolas_S_feature" /locus_tag="new_4035641_4035833_c" /HighExp="Diami, T0.30H, B60, T0.0H, G150, M9-stat, T1.0H, T1.30H, Gly, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29980099999999998" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.998, 0.994, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1513" promotor_-10 complement(3536699..3536718) /Source="Nicolas_upshift_promotors" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3536718) /Source="Nicolas_upshifts" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3536720..3536853) /Source="Nicolas_S_feature" /locus_tag="new_4035835_4035968_c" /HighExp="S2, HiTm, Sw, S8, M9-stat, Lbstat, S0, T2.0H, Mal, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.994, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1514" promotor_-35 complement(3536731..3536738) /Source="Nicolas_upshift_promotors" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3536875..3537183) /gene="yxxE" /locus_tag="BSU_39280" /old_locus_tag="BSU39280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391807.1" /db_xref="EnsemblGenomes-Gn:BSU39280" /db_xref="EnsemblGenomes-Tr:CAB15964" /db_xref="SubtiList:BG11071" /db_xref="UniProtKB/Swiss-Prot:P40738" /translation="MLLINKQKDPVFQFLAGTFHQDIETPDDAIQELLIEESKEYLED AIVFLTDFIESEHSDNKKNDYIQSCADGVYLPAFNLEPIDWLKNVIVQIKKSLKKFKR *" /label="yxxE CDS" gene complement(3536875..3537183) /gene="yxxE" /locus_tag="BSU_39280" /old_locus_tag="BSU39280" /label="yxxE gene" downshifts complement(3536898) /Source="Nicolas_upshifts" /id="D2040" /incds=0 /nref=137 /ntot=221 /MaxReadThrough="3.99098" /MaxDrop="5.76651" /score="24.0715465" /energy="-21.3" /TU="U3101,U3102" /idTUdmin="U3101" /TUdmin="-3718" /isTUend="FALSE" /label="downshifts" CDS complement(3537229..3537672) /gene="rtbE" /locus_tag="BSU_39290" /old_locus_tag="BSU39290" /function="17: Mobile and extrachromosomal element functions" /experiment="publication(s) with functional evidences, PMID:22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22200572; Product type f: factor" /codon_start=1 /transl_table=11 /product="antitoxin factor of the RttD-RttE toxin-antitoxin system" /protein_id="NP_391808.1" /db_xref="EnsemblGenomes-Gn:BSU39290" /db_xref="EnsemblGenomes-Tr:CAB15965" /db_xref="InterPro:IPR018958" /db_xref="SubtiList:BG11070" /db_xref="UniProtKB/Swiss-Prot:P40737" /translation="MSYNFIKSNKENDFYPVNQSEIEEVEKNLNLKLPSELVNFYLEV GYGFIKGSEFNTNRILDPYSVRDFRLRINDFEFYPDIEIYDEFENDKLIFFEGSESAL MSIELNDNNKNPIYYYDIQIATSLTEFLRKIEENDQYYLDLLDDE*" /label="rtbE CDS" gene complement(3537229..3537672) /gene="rtbE" /locus_tag="BSU_39290" /old_locus_tag="BSU39290" /label="rtbE gene" CDS complement(3537669..3539378) /gene="rtbD" /locus_tag="BSU_39300" /old_locus_tag="BSU39300" /function="17: Mobile and extrachromosomal element functions" /experiment="publication(s) with functional evidences, PMID:22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease toxin of the RtbD-RtbE toxin-antitoxin system" /protein_id="NP_391809.2" /db_xref="EnsemblGenomes-Gn:BSU39300" /db_xref="EnsemblGenomes-Tr:CAB15966" /db_xref="GOA:P42296" /db_xref="InterPro:IPR003615" /db_xref="InterPro:IPR006829" /db_xref="InterPro:IPR027797" /db_xref="SubtiList:BG11133" /db_xref="UniProtKB/Swiss-Prot:P42296" /translation="MKTLDVHALHEGIQHTIEKLDKQKQQLEKLEKSVEHLAGMKDAL KGKGGDAIRTFYEECHKPFLLFFGIFIDEYKKVLKQTQHAISSVESNSHGMIAEAFLS HDARHGVKHAREVTEQLTDAVNRQTSAIDHIVSLPTVNDSFFRMETEQAERLISDTLN KLFQFDGQQTQALEAAKSDFQTMKKYIDQLETMYTGPKIEITGYKSGSILKSQEEENI NQIFGAINPQMKQADDSPMEMMLKKLAENEKSKVDSVVKTGDSKKVSKNIIVINGKVY NTSEHREHIKTDFSNAEVKQVVYNDTLYNVYISGNDMKLEPVVSLSDIKVDENGYVKI LETAVELTGVYDLFKAATGRDPVSGEKVTGKDRVVASINSVPFAKIAKLEKLIDINKL INNGKKAKKASEVKNVAKDKGKIANDVSGSANKINSDLIKKYARDIEQRTGRELPKNQ IDKLKEALRNKEYKKMSPIETAKHRTKFDKVKNKVIKEWEENTGQKWPVYKENVVSEK TGKIIRKKGDKYDAHHIIENTFGGEHEWWNMHPAKFPNEHQAGIHGTGSPANELFKGG KKK*" /label="rtbD CDS" gene complement(3537669..3539378) /gene="rtbD" /locus_tag="BSU_39300" /old_locus_tag="BSU39300" /label="rtbD gene" misc_feature complement(3538540..3538559) /Source="Nicolas_upshift_promotors" /id="U3101" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.551448551448551" /psig="0.994005994005994" /xcortree=1873 /SigmaFactorBS="aacgggtgattctaaaaaggtaagtaaaaatatcatcgttat caatggtAAAGTGTATAATACGAGTGAacatagagaacatataaaaactgatttctca a" /listShort="yxxD, yxxE, S1514, S1513, bglP, bglH" /listLong="yxiE" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3538548) /Source="Nicolas_upshifts" /id="U3101" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.551448551448551" /psig="0.994005994005994" /xcortree=1873 /SigmaFactorBS="aacgggtgattctaaaaaggtaagtaaaaatatcatcgttat caatggtAAAGTGTATAATACGAGTGAacatagagaacatataaaaactgatttctca a" /listShort="yxxD, yxxE, S1514, S1513, bglP, bglH" /listLong="yxiE" /label="upshifts" CDS complement(3539398..3539667) /gene="yxiC" /locus_tag="BSU_39310" /old_locus_tag="BSU39310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391810.1" /db_xref="EnsemblGenomes-Gn:BSU39310" /db_xref="EnsemblGenomes-Tr:CAB15967" /db_xref="InterPro:IPR020315" /db_xref="SubtiList:BG11132" /db_xref="UniProtKB/Swiss-Prot:P42295" /translation="MAQEIKMVYDTVKQGLSQLKNSAELKSSLPGHLSGRNHLNVVKS IEQLNKDIKELTEAYASVLAKHIAQTESAVNAMKETDENISSSMK*" /label="yxiC CDS" gene complement(3539398..3539667) /gene="yxiC" /locus_tag="BSU_39310" /old_locus_tag="BSU39310" /label="yxiC gene" CDS complement(3539679..3540044) /gene="yxiB" /locus_tag="BSU_39320" /old_locus_tag="BSU39320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391811.1" /db_xref="EnsemblGenomes-Gn:BSU39320" /db_xref="EnsemblGenomes-Tr:CAB15968" /db_xref="InterPro:IPR031681" /db_xref="SubtiList:BG11131" /db_xref="UniProtKB/Swiss-Prot:P42294" /translation="MHSEMLLHSVKADLHEKQEQIHQLKRVLHEIRQIKHDFSEAQHL IHRPHLNREAWRGTHAERFEDIREGMNKAYQQIKSDQVSGIIESIEGKIHSLEGDVYS IRRQITRIEHEIEKEKHKK*" /label="yxiB CDS" gene complement(3539679..3540044) /gene="yxiB" /locus_tag="BSU_39320" /old_locus_tag="BSU39320" /label="yxiB gene" S_feature complement(3540045..3540110) /Source="Nicolas_S_feature" /locus_tag="new_4039160_4039225_c" /HighExp="T-1.40H, T-3.40H, T2.30H, T-2.40H, T-0.40H, T1.0H, T-1.10H, T-5.40H, T3.30H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1515" promotor_-10 complement(3540097..3540116) /Source="Nicolas_upshift_promotors" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3540110) /Source="Nicolas_upshifts" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3540131..3540134) /Source="Nicolas_upshift_promotors" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3540351..3541760) /gene="abnB" /locus_tag="BSU_39330" /old_locus_tag="BSU39330" /EC_number="3.2.1.99" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 18408032, 18607095, 20883454" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 18408032, 18607095, 20883454; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinan endo-1,5-alpha-L-arabinosidase ([Ca(2+)-dependent]" /protein_id="NP_391812.2" /db_xref="EnsemblGenomes-Gn:BSU39330" /db_xref="EnsemblGenomes-Tr:CAB15969" /db_xref="GOA:P42293" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR023296" /db_xref="InterPro:IPR032291" /db_xref="PDB:2X8F" /db_xref="PDB:2X8S" /db_xref="PDB:2X8T" /db_xref="PDB:4COT" /db_xref="SubtiList:BG11130" /db_xref="UniProtKB/Swiss-Prot:P42293" /translation="MFNRLFRVCFLAALIMAFTLPNSVYAQKPIFKEVSVHDPSIIET NGTFYVFGSHLASAKSNDLMQWQQLTTSVSNDNPLIPNVYEELKETFEWAQSDTLWAA DVTQLADGKYYMYYNACRGDSPRSAMGVAVADNIEGPYKNKGIFLKSGMEGTSSDGTP YDATKHPNVVDPHTFFDKDGKLWMVYGSYSGGIFILEMNPKTGFPLPGQGYGKKLLGG NHSRIEGPYVLYNPDTQYYYLYLSYGGLDATGGYNIRVARSKKPDGPYYDAEGNPMLD VRGKGGTFFDDRSIEPYGVKLMGSYTFETENEKGTGYVSPGHNSAYYDEKTGRSYLIF HTRFPGRGEEHEVRVHQLFMNKDGWPVAAPYRYAGETLKEVKQKDITGTYKLIQHGKD ISADIKQTINIQLNKNHTISGEMTGTWRKTGKNTADITLAGKKYNGVFLRQWDSVREK NVMTFSVLNTSGEAVWGSK*" /label="abnB CDS" gene complement(3540351..3541760) /gene="abnB" /locus_tag="BSU_39330" /old_locus_tag="BSU39330" /label="abnB gene" downshifts complement(3540374) /Source="Nicolas_upshifts" /id="D2041" /incds=0 /nref=2 /ntot=38 /MaxReadThrough="0.825980000000001" /MaxDrop="3.49689" /score="16.962389" /energy="-7.9" /TU="NA" /idTUdmin="U3101" /TUdmin="-7194" /isTUend="FALSE" /label="downshifts" S_feature complement(3541761..3541870) /Source="Nicolas_S_feature" /locus_tag="new_4040876_4040985_c" /HighExp="S2, T2.30H, BC, T2.0H, M9-stat, T3.0H, T3.30H, T4.0H, S1, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1516" CDS complement(3541894..3542058) /gene="yxzL" /locus_tag="BSU_39339" /old_locus_tag="BSU39339" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097797.1" /db_xref="EnsemblGenomes-Gn:BSU39339" /db_xref="EnsemblGenomes-Tr:CAX52712" /db_xref="UniProtKB/Swiss-Prot:C0H3T6" /translation="MAVSQLMQNLTKQLLHVRERKTDVMQEGETAKELNYEGEDMQAT SSAQNRQTSV*" /label="yxzL CDS" gene complement(3541894..3542058) /gene="yxzL" /locus_tag="BSU_39339" /old_locus_tag="BSU39339" /label="yxzL gene" promotor_-10 complement(3541943..3541961) /Source="Nicolas_upshift_promotors" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3541958) /Source="Nicolas_upshifts" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3541972..3541980) /Source="Nicolas_upshift_promotors" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3542250..3542269) /Source="Nicolas_upshift_promotors" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3542266) /Source="Nicolas_upshifts" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3542282..3542289) /Source="Nicolas_upshift_promotors" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3542298..3542305 /Source="Nicolas_upshift_promotors" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3542320..3542339 /Source="Nicolas_upshift_promotors" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3542323 /Source="Nicolas_upshifts" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="upshifts" CDS 3542377..3542823 /gene="hutP" /locus_tag="BSU_39340" /old_locus_tag="BSU39340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15758992, 16192572, 16427271, 17395359, 18445631, 23748184, 24650662" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15758992, 16192572, 16427271, 17395359, 18445631, 23748184, 24650662; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator" /protein_id="NP_391813.2" /db_xref="EnsemblGenomes-Gn:BSU39340" /db_xref="EnsemblGenomes-Tr:CAB15970" /db_xref="GOA:P10943" /db_xref="InterPro:IPR015111" /db_xref="InterPro:IPR023552" /db_xref="InterPro:IPR036482" /db_xref="PDB:1VEA" /db_xref="PDB:1WMQ" /db_xref="PDB:1WPS" /db_xref="PDB:1WPT" /db_xref="PDB:1WPU" /db_xref="PDB:1WPV" /db_xref="PDB:1WRN" /db_xref="PDB:1WRO" /db_xref="PDB:1WRQ" /db_xref="PDB:3BOY" /db_xref="PDB:4H4L" /db_xref="SubtiList:BG10666" /db_xref="UniProtKB/Swiss-Prot:P10943" /translation="MTLHKERRIGRLSVLLLLNEAEESTQVEELERDGWKVCLGKVGS MDAHKVVAAIETASKKSGVIQSEGYRESHALYHATMEALHGVTRGEMLLGSLLRTVGL RFAVLRGNPYESEAEGDWIAVSLYGTIGAPIKGLEHETFGVGINHI*" /label="hutP CDS" gene 3542377..3542823 /gene="hutP" /locus_tag="BSU_39340" /old_locus_tag="BSU39340" /label="hutP gene" downshifts 3542828 /Source="Nicolas_upshifts" /id="D2042" /incds=0 /nref=157 /ntot=226 /MaxReadThrough="6.10706" /MaxDrop="5.43744" /score="3.19376411" /energy="-17.8" /TU="U3105" /idTUdmin="U3105" /TUdmin="-7018" /isTUend="FALSE" /label="downshifts" CDS 3542936..3544462 /gene="hutH" /locus_tag="BSU_39350" /old_locus_tag="BSU39350" /EC_number="4.3.1.3" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9535092, 10220322, 17395359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidine ammonia-lyase (histidase)" /protein_id="NP_391814.1" /db_xref="EnsemblGenomes-Gn:BSU39350" /db_xref="EnsemblGenomes-Tr:CAB15971" /db_xref="GOA:P10944" /db_xref="InterPro:IPR001106" /db_xref="InterPro:IPR005921" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR022313" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10667" /db_xref="UniProtKB/Swiss-Prot:P10944" /translation="MVTLDGSSLTTADVARVLFDFEEAAASEESMERVKKSRAAVERI VRDEKTIYGINTGFGKFSDVLIQKEDSAALQLNLILSHACGVGDPFPECVSRAMLLLR ANALLKGFSGVRAELIEQLLAFLNKRVHPVIPQQGSLGASGDLAPLSHLALALIGQGE VFFEGERMPAMTGLKKAGIQPVTLTSKEGLALINGTQAMTAMGVVAYIEAEKLAYQTE RIASLTIEGLQGIIDAFDEDIHLARGYQEQIDVAERIRFYLSDSGLTTSQGELRVQDA YSLRCIPQVHGATWQTLGYVKEKLEIEMNAATDNPLIFNDGDKVISGGNFHGQPIAFA MDFLKIAISELANIAERRIERLVNPQLNDLPPFLSPHPGLQSGAMIMQYAAASLVSEN KTLAHPASVDSIPSSANQEDHVSMGTIAARHAYQVIANTRRVIAIEAICALQAVEYRG IEHAASYTKQLFQEMRKVVPSIQQDRVFSYDIERLTDWLKKESLIPDHQNKELRGMNI *" /label="hutH CDS" gene 3542936..3544462 /gene="hutH" /locus_tag="BSU_39350" /old_locus_tag="BSU39350" /label="hutH gene" CDS 3544459..3546117 /gene="hutU" /locus_tag="BSU_39360" /old_locus_tag="BSU39360" /EC_number="4.2.1.49" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15313616, 17395359, 22933560; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urocanase" /protein_id="NP_391815.1" /db_xref="EnsemblGenomes-Gn:BSU39360" /db_xref="EnsemblGenomes-Tr:CAB15972" /db_xref="GOA:P25503" /db_xref="InterPro:IPR023636" /db_xref="InterPro:IPR023637" /db_xref="InterPro:IPR035085" /db_xref="InterPro:IPR035400" /db_xref="InterPro:IPR035401" /db_xref="InterPro:IPR036190" /db_xref="PDB:2FKN" /db_xref="SubtiList:BG10668" /db_xref="UniProtKB/Swiss-Prot:P25503" /translation="MTDVKKSIRANRGTELECLGWEQEAVLRMLRNNLDPEVAEKPED LIVYGGIGKAARDWDAFHAIEHSLKTLKNDETLLVQSGKPVGMFRTHPQAPRVLLANS VLVPKWADWEHFHELEKKGLMMYGQMTAGSWIYIGSQGILQGTYETFAELARQHFGGS LKGTLTLTAGLGGMGGAQPLSVTMNEGVVIAVEVDEKRIDKRIETKYCDRKTASIEEA LAWAEEAKLAGKPLSIALLGNAAEVHHTLLNRGVKIDIVTDQTSAHDPLIGYVPEGYS LDEADRLRQDTPELYVRLAKQSMKKHVEAMLAFQQKGSIVFDYGNNIRQVAKDEGLEN AFDFPGFVPAYIRPLFCEGKGPFRWAALSGDPADIYRTDALLKELFPTNKALHRWIDM AQEKVTFQGLPSRICWLGYGERKKMGLAINELVRTGELKAPVVIGRDHLDCGSVASPN RETEAMKDGSDAVGDWAVLNALVNTAAGASWVSFHHGGGVGMGYSLHAGMVAVADGSE LADERLARVLTSDPGMGIIRHADAGYERAVEVAKEQDIIVPMQK*" /label="hutU CDS" gene 3544459..3546117 /gene="hutU" /locus_tag="BSU_39360" /old_locus_tag="BSU39360" /label="hutU gene" CDS 3546130..3547395 /gene="hutI" /locus_tag="BSU_39370" /old_locus_tag="BSU39370" /EC_number="3.5.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16990261, 17395359, 18296777" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16990261, 17395359, 18296777; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazolone-5-propionate hydrolase" /protein_id="NP_391816.1" /db_xref="EnsemblGenomes-Gn:BSU39370" /db_xref="EnsemblGenomes-Tr:CAB15973" /db_xref="GOA:P42084" /db_xref="InterPro:IPR005920" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="PDB:2BB0" /db_xref="PDB:2G3F" /db_xref="SubtiList:BG11100" /db_xref="UniProtKB/Swiss-Prot:P42084" /translation="MPKQIDTILINIGQLLTMESSGPRAGKSMQDLHVIEDAVVGIHE QKIVFAGQKGAEAGYEADEIIDCSGRLVTPGLVDPHTHLVFGGSREKEMNLKLQGISY LDILAQGGGILSTVKDTRAASEEELLQKAHFHLQRMLSYGTTTAEVKSGYGLEKETEL KQLRVAKKLHESQPVDLVSTFMGAHAIPPEYQNDPDDFLDQMLSLLPEIKEQELASFA DIFTETGVFTVSQSRRYLQKAAEAGFGLKIHADEIDPLGGAELAGKLKAVSADHLVGT SDEGIKKLAEAGTIAVLLPGTTFYLGKSTYARARAMIDEGVCVSLATDFNPGSSPTEN IQLIMSIAALHLKMTAEEIWHAVTVNAAYAIGKGEEAGQLKAGRSADLVIWQAPNYMY IPYHYGVNHVHQVMKNGTIVVNREGAILG*" /label="hutI CDS" gene 3546130..3547395 /gene="hutI" /locus_tag="BSU_39370" /old_locus_tag="BSU39370" /label="hutI gene" CDS 3547388..3548347 /gene="hutG" /locus_tag="BSU_39380" /old_locus_tag="BSU39380" /EC_number="3.5.3.8" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10931887, 15355972, 17395359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formiminoglutamate hydrolase" /protein_id="NP_391817.1" /db_xref="EnsemblGenomes-Gn:BSU39380" /db_xref="EnsemblGenomes-Tr:CAB15974" /db_xref="GOA:P42068" /db_xref="InterPro:IPR005923" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="PDB:3M1R" /db_xref="SubtiList:BG11099" /db_xref="UniProtKB/Swiss-Prot:P42068" /translation="MDKYPFLREAGSSFKDRDVTKMSDLIATWDGQDIKGPALIGVPL SKSSISHSGASFAPGTIRQALKHSSAYSAELGEHVVSELLYDLGDIDIHVTDIVKSHH HIFQTMHALLSDHPDWVPLILGGDNSISYSTIKAIAQTKGTTAVIQFDAHHDVRNTED GGPTNGTPFRRLLDEEIIEGQHLIQLGIREFSNSQAYEAYAKKHNVNIHTMDMIREKG LIPTIKEILPVVQDKTDFIFISVDMDVLDQSHAPGCPAIGPGGLYTDELLEAVKYIAQ QPNVAGIEIVEVDPTLDFRDMTSRAAAHVLLHALKGMKLSPFK*" /label="hutG CDS" gene 3547388..3548347 /gene="hutG" /locus_tag="BSU_39380" /old_locus_tag="BSU39380" /label="hutG gene" S_feature 3548348..3548422 /Source="Nicolas_S_feature" /locus_tag="new_4047463_4047537" /HighExp="Sw, BC, T3.30H, T4.0H, T5.0H, T3.0H, T2.30H, S8, M9-stat, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1517" CDS 3548423..3549850 /gene="hutM" /locus_tag="BSU_39390" /old_locus_tag="BSU39390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7704263, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="histidine degradation metabolites permease" /protein_id="NP_391818.2" /db_xref="EnsemblGenomes-Gn:BSU39390" /db_xref="EnsemblGenomes-Tr:CAB15975" /db_xref="GOA:P42087" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG11101" /db_xref="UniProtKB/Swiss-Prot:P42087" /translation="MNLQENSSQQLKRTMKSRHLFMISLGGVIGTGLFLSTGYTLHQA GPGGTILAYVIGGLMMYLVMQCLGELSVAMPVTGSFQKYATTFIGPSTGFMVGIMYWI NWVVTVGSEFTASGILMQRWFPDSSVWMWSAIFAALLFICNAFSVKLFAETEFWFSSV KIVTIILFIILGGAAMFGLISLNGTADAPMLSNFTDHGGLFPNGFLAVFIAMISVSFA FSGTELIGVTAGESANPQKDIPRSIRNVAWRTVIFFIGAVFILSGLISWKDAGVIESP FVAVFAEIGIPYAADIMNFVILTALLSVANSGLYASTRMMWSLANENMISSRFKKVTS KGIPLNALMISMAVSCLSLVSSIVAPGTVYVVMVAIAGFAGVVVWMSIALSQLLFRKR FLKKGGDVKDLTFRTPLYPLMPIAALLLCSASCIGLAFDPNQRIALFCGVPCIILCYL IYHFKRNVTKAKKISQEEYPADHIL*" /label="hutM CDS" gene 3548423..3549850 /gene="hutM" /locus_tag="BSU_39390" /old_locus_tag="BSU39390" /label="hutM gene" downshifts 3549846 /Source="Nicolas_upshifts" /id="D2043" /incds=0 /nref=11 /ntot=31 /MaxReadThrough="0.7432" /MaxDrop="6.18816" /score="8.21347356" /energy="-11.7" /TU="NA" /idTUdmin="U3105" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3549894..3551195) /gene="pdp" /locus_tag="BSU_39400" /old_locus_tag="BSU39400" /EC_number="2.4.2.2" /EC_number="2.4.2.3" /EC_number="2.4.2.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 11065368, 15530033, 16469506, 21707079" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 11065368, 15530033, 16469506, 21707079; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-nucleoside phosphorylase" /protein_id="NP_391819.2" /db_xref="EnsemblGenomes-Gn:BSU39400" /db_xref="EnsemblGenomes-Tr:CAB15976" /db_xref="GOA:P39142" /db_xref="InterPro:IPR000053" /db_xref="InterPro:IPR000312" /db_xref="InterPro:IPR013102" /db_xref="InterPro:IPR017459" /db_xref="InterPro:IPR017872" /db_xref="InterPro:IPR018090" /db_xref="InterPro:IPR035902" /db_xref="InterPro:IPR036320" /db_xref="InterPro:IPR036566" /db_xref="PDB:5EP8" /db_xref="SubtiList:BG10985" /db_xref="UniProtKB/Swiss-Prot:P39142" /translation="MRMVDIIIKKQNGKELTTEEIQFFVNGYTDGSIPDYQASALAMA IFFQDMSDRERADLTMAMVNSGETIDLSAIEGIKVDKHSTGGVGDTTTLVLAPLVAAL DVPVAKMSGRGLGHTGGTIDKLEAIMGFHVELTKDEFIKLVNRDKVAVIGQSGNLTPA DKKLYALRDVTGTVNSIPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKTEEDAAELA KAMVRIGNNVGRQTMAVISDMSQPLGFAIGNALEVKEAIDTLKGEGPEDLHELVLTLG SQMVVLAKKADTLDEARAKLEEVMKNGKALEKFKDFLKNQGGDSSIVDDPSKLPQAAY QIDVPAKEAGVVSEIVADEIGVAAMLLGAGRATKEDEIDLAVGIMLRKKVGDKVEKGE PLVTLYANRENVDEVIAKVYDNIRIAAEAKAPKLIHTLITE*" /label="pdp CDS" gene complement(3549894..3551195) /gene="pdp" /locus_tag="BSU_39400" /old_locus_tag="BSU39400" /label="pdp gene" downshifts complement(3549911) /Source="Nicolas_upshifts" /id="D2044" /incds=0 /nref=122 /ntot=224 /MaxReadThrough="1.27022" /MaxDrop="5.60021" /score="14.0361257" /energy="-13.1" /TU="NA" /idTUdmin="U3107" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(3551225..3552406) /gene="nupC" /locus_tag="BSU_39410" /old_locus_tag="BSU39410" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8550462, 11065368, 12591866, 15849754, 16850406, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 11065368, 12591866, 15849754, 16850406, 25890046; Product type t : transporter" /codon_start=1 /transl_table=11 /product="pyrimidine-nucleoside Na+(H+) cotransporter" /protein_id="NP_391820.2" /db_xref="EnsemblGenomes-Gn:BSU39410" /db_xref="EnsemblGenomes-Tr:CAB15977" /db_xref="GOA:P39141" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG10984" /db_xref="UniProtKB/Swiss-Prot:P39141" /translation="MKYLIGIIGLIVFLGLAWIASSGKKRIKIRPIVVMLILQFILGY ILLNTGIGNFLVGGFAKGFGYLLEYAAEGINFVFGGLVNADQTTFFMNVLLPIVFISA LIGILQKWKVLPFIIRYIGLALSKVNGMGRLESYNAVASAILGQSEVFISLKKELGLL NQQRLYTLCASAMSTVSMSIVGAYMTMLKPEYVVTALVLNLFGGFIIASIINPYEVAK EEDMLRVEEEEKQSFFEVLGEYILDGFKVAVVVAAMLIGFVAIIALINGIFNAVFGIS FQGILGYVFAPFAFLVGIPWNEAVNAGSIMATKMVSNEFVAMTSLTQNGFHFSGRTTA IVSVFLVSFANFSSIGIIAGAVKGLNEKQGNVVARFGLKLLYGATLVSFLSAAIVGLI Y*" /label="nupC CDS" gene complement(3551225..3552406) /gene="nupC" /locus_tag="BSU_39410" /old_locus_tag="BSU39410" /label="nupC gene" S_feature complement(3552407..3552486) /Source="Nicolas_S_feature" /locus_tag="new_4051522_4051601_c" /HighExp="G150, G135, Oxctl, G180, Mt0, M40t45, Lbtran, M0t90, M40t90, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1518" CDS complement(3552487..3553158) /gene="deoC" /locus_tag="BSU_39420" /old_locus_tag="BSU39420" /EC_number="4.1.2.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 11065368, 27033207" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 11065368, 27033207; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyribose-phosphate aldolase" /protein_id="NP_391821.2" /db_xref="EnsemblGenomes-Gn:BSU39420" /db_xref="EnsemblGenomes-Tr:CAB15978" /db_xref="GOA:P39121" /db_xref="InterPro:IPR002915" /db_xref="InterPro:IPR011343" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR028581" /db_xref="SubtiList:BG10983" /db_xref="UniProtKB/Swiss-Prot:P39121" /translation="MSLANIIDHTALKPHTQKADILKLIEEAKTYKFASVCVNPTWVE LAAKELKGTGVDVCTVIGFPLGANTTETKAFETKDAISKGATEVDMVINIAALKDKED DVVEADIRGVVEAVAGKALVKVIIETCLLTDEEKERACRLAVSAGADFVKTSTGFSTG GATKEDIALMRKTVGPDIGVKASGGVRTKEDVDTMVEAGASRIGASAGVSIVKGENAS GGDNY*" /label="deoC CDS" gene complement(3552487..3553158) /gene="deoC" /locus_tag="BSU_39420" /old_locus_tag="BSU39420" /label="deoC gene" promotor_-35 3553107..3553110 /Source="Nicolas_upshift_promotors" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3553125 /Source="Nicolas_upshifts" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3553126..3553145 /Source="Nicolas_upshift_promotors" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3553186..3553205) /Source="Nicolas_upshift_promotors" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3553201) /Source="Nicolas_upshifts" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3553219..3553226) /Source="Nicolas_upshift_promotors" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3553264..3554205) /gene="deoR" /locus_tag="BSU_39430" /old_locus_tag="BSU39430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 10714997, 24863636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 10714997, 24863636; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of pyrmidine deoxyribonucleosides degradation (DeoR-dR5P)" /protein_id="NP_391822.1" /db_xref="EnsemblGenomes-Gn:BSU39430" /db_xref="EnsemblGenomes-Tr:CAB15979" /db_xref="GOA:P39140" /db_xref="InterPro:IPR007324" /db_xref="InterPro:IPR013324" /db_xref="PDB:4OQP" /db_xref="PDB:4OQQ" /db_xref="SubtiList:BG10982" /db_xref="UniProtKB/Swiss-Prot:P39140" /translation="MDREKQQLSIEAARLYYQSDYSQQQIAEQLNISRPTVSRLLQYA KEKGYVQIRVMDPFEDLDALGSILEEKYGLLEAHVVFSPTPDYAGITHDLSRYGAEYM HETVKDGDIVGVSWGTTMYQIAQNMQPKQVKGVEVVQLKGGISHSRVNTYSAETIQLF AEAFQTMPRYLPLPVVFDNADVKRMVEKDRHIERIIEMGKQANIALFTVGTVRDEALL FRLGYFNEEEKALLKKQAVGDICSRFFDAKGNICSSAINDRTIGVELQDLRLKERSIL VAGGSRKVSSIHGALTGKYANVLIIDQHTARALVNDL*" /label="deoR CDS" gene complement(3553264..3554205) /gene="deoR" /locus_tag="BSU_39430" /old_locus_tag="BSU39430" /label="deoR gene" promotor_-10 complement(3554250..3554269) /Source="Nicolas_upshift_promotors" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3554256) /Source="Nicolas_upshifts" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3554258..3554338) /Source="Nicolas_S_feature" /locus_tag="new_4053373_4053453_c" /HighExp="Etha, Diami, Salt, MG 10, Gly, MG 60, G180, GM 60, G135, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.55204399999999998" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1519" promotor_-35 complement(3554285..3554288) /Source="Nicolas_upshift_promotors" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3554339..3555166) /gene="yxxB" /locus_tag="BSU_39440" /old_locus_tag="BSU39440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10746760, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391823.2" /db_xref="EnsemblGenomes-Gn:BSU39440" /db_xref="EnsemblGenomes-Tr:CAB15980" /db_xref="GOA:P39139" /db_xref="InterPro:IPR009597" /db_xref="SubtiList:BG10981" /db_xref="UniProtKB/Swiss-Prot:P39139" /translation="MAVKDRYMSKIKQETKPWIKRFGRLGYFAFGGVFILLGVLAFMT AAGAGRAKDSSGALQTLSRMPYGSLLLFFIGIGLIGYVIWMVLSAIKDTEGHGNSRRG LSRRIGNFFSAAVYTSIAWNALRFVFGQGDGGTSEQTWSAYVLAQPFGQWLTGLTGAG FIVFAIVQFMKGVRAAFMKEFDTSKMNKQMICITKNTGRAGNIARAIIFSAIGYFLIK TAMTADPDDTRGFDGALAELAQQPHGKLILSILALGLILYGMYAIMKGIYQHMTWEK* " /label="yxxB CDS" gene complement(3554339..3555166) /gene="yxxB" /locus_tag="BSU_39440" /old_locus_tag="BSU39440" /label="yxxB gene" downshifts complement(3555138) /Source="Nicolas_upshifts" /id="D2045" /incds=0 /nref=6 /ntot=96 /MaxReadThrough="4.46865" /MaxDrop="3.48502" /score="14.6805498" /energy="-16" /TU="U3109,U3111" /idTUdmin="U3111" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3555191..3555209) /Source="Nicolas_upshift_promotors" /id="U3109" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=169 /SigmaFactorBS="aacgtatctcagccagccatagctgaggcaggagcTGTTTCA actttgttcaatcGGGAATGTTACAGTAAAGAtttctgtgaaagagggttggacacat g" /listShort="yxxB, S1519, deoR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3555204) /Source="Nicolas_upshifts" /id="U3109" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=169 /SigmaFactorBS="aacgtatctcagccagccatagctgaggcaggagcTGTTTCA actttgttcaatcGGGAATGTTACAGTAAAGAtttctgtgaaagagggttggacacat g" /listShort="yxxB, S1519, deoR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3555223..3555229) /Source="Nicolas_upshift_promotors" /id="U3109" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=169 /SigmaFactorBS="aacgtatctcagccagccatagctgaggcaggagcTGTTTCA actttgttcaatcGGGAATGTTACAGTAAAGAtttctgtgaaagagggttggacacat g" /listShort="yxxB, S1519, deoR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3555239..3556351) /gene="yxeR" /locus_tag="BSU_39450" /old_locus_tag="BSU39450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1860825, 10746760, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ethanolamine permease" /protein_id="NP_391824.1" /db_xref="EnsemblGenomes-Gn:BSU39450" /db_xref="EnsemblGenomes-Tr:CAB15981" /db_xref="GOA:P54957" /db_xref="InterPro:IPR007441" /db_xref="SubtiList:BG11894" /db_xref="UniProtKB/Swiss-Prot:P54957" /translation="MTVNDAVVFILAAFLLWGAADYCLGNRWGLGERFADGFKAMGPL ALSMIGIVSLAPVLAAILIPIVAPFYTAIGADPSSFANTILAIDMGGYALAGEMAKDP QAGLFSWVFLGTMMGPAIVFTIPVALGIIEKEDHPYFAKGILIGLCTVPIGCLIGGLC AGFDIGMIGKNLLIPSLLSAVIAFGLWRYTDRMIQLFHLFGKAVSMVAIIGLAAVSVE TMTGIVLIPGMENVETGIQTTGTIAIALAGAFPMTAFITKTFKKPLQALGKCLHLDET ATAGLVTSLAHHIPMLASLKDMTPRGKVINVAFAVSGAFVLGSHLGFVAGMKKEMAAA MIIGKLAGGVTAAAAAAWMTPAQSAKQQKRISASHS*" /label="yxeR CDS" gene complement(3555239..3556351) /gene="yxeR" /locus_tag="BSU_39450" /old_locus_tag="BSU39450" /label="yxeR gene" CDS complement(3556421..3557758) /gene="yxeQ" /locus_tag="BSU_39460" /old_locus_tag="BSU39460" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 16885442; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative catabolic enzyme" /protein_id="NP_391825.2" /db_xref="EnsemblGenomes-Gn:BSU39460" /db_xref="EnsemblGenomes-Tr:CAB15982" /db_xref="GOA:P54956" /db_xref="InterPro:IPR005656" /db_xref="InterPro:IPR036148" /db_xref="SubtiList:BG11893" /db_xref="UniProtKB/Swiss-Prot:P54956" /translation="MSKQGLTAGLAEAVRTSQPEHSVDAIHEAKKGLLDFTAASFAGR EDKGIQKLLRLIEDEGGRPLVPVIGQGKKAAPLQSAMLNGFIAHALDFDDVHSDVRGH PSAVIVPALIASAARGHDERLLGAYVVGVEVMARLGESIGSRHYEKGWHNTGTLGAIA AACAVGYAEELTQEELEKAIGFAATQSAGMRVQFGTEMKPLHAGLAAQAGLLAVKLAQ SEFGGSRTALDGETGFFSLYGDVEKAQHTLLNDWGAPWRIVQPGLWFKIYPFCSAAHH AADAVRQLISEETISAANTERIEVIFPPGGDAALTERSPKAGEEGRFSVEYVIALALH GHGLTVEHFSSQPIPNGVQTTMGRIQRVYDNAIQPAPHAVPKGRFTIVRAYLSDGRIC EARVDCPKGAPGNELSEEDIIEKLTLTVPQEKARRIITAVEKADIKEFLAHIE*" /label="yxeQ CDS" gene complement(3556421..3557758) /gene="yxeQ" /locus_tag="BSU_39460" /old_locus_tag="BSU39460" /label="yxeQ gene" CDS complement(3557755..3558897) /gene="sndB" /locus_tag="BSU_39470" /old_locus_tag="BSU39470" /EC_number="3.5.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12193636, 16513748, 16885442, 23944997, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193636, 16513748, 16885442, 23944997, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-sulfur-metabolite deacetylase" /protein_id="NP_391826.2" /db_xref="EnsemblGenomes-Gn:BSU39470" /db_xref="EnsemblGenomes-Tr:CAB15983" /db_xref="GOA:P54955" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR033846" /db_xref="InterPro:IPR036264" /db_xref="PDB:1YSJ" /db_xref="SubtiList:BG11892" /db_xref="UniProtKB/Swiss-Prot:P54955" /translation="MADKAFHTRLINMRRDLHEHPELSFQEVETTKKIRRWLEEEQIE ILDVPQLKTGVIAEIKGREDGPVIAIRADIDALPIQEQTNLPFASKVDGTMHACGHDF HTASIIGTAMLLNQRRAELKGTVRFIFQPAEEIAAGARKVLEAGVLNGVSAIFGMHNK PDLPVGTIGVKEGPLMASVDRFEIVIKGKGGHAGIPNNSIDPIAAAGQIISGLQSVVS RNISSLQNAVVSITRVQAGTSWNVIPDQAEMEGTVRTFQKEARQAVPEHMRRVAEGIA AGYGAQAEFKWFPYLPSVQNDGTFLNAASEAAARLGYQTVHAEQSPGGEDFALYQEKI PGFFVWMGTNGTEEWHHPAFTLDEEALTVASQYFAELAVIVLETIK*" /label="sndB CDS" gene complement(3557755..3558897) /gene="sndB" /locus_tag="BSU_39470" /old_locus_tag="BSU39470" /label="sndB gene" CDS complement(3558914..3559663) /gene="yxeO" /locus_tag="BSU_39480" /old_locus_tag="BSU39480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 16885442, 25875741; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_391827.1" /db_xref="EnsemblGenomes-Gn:BSU39480" /db_xref="EnsemblGenomes-Tr:CAB15984" /db_xref="GOA:P54954" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11891" /db_xref="UniProtKB/Swiss-Prot:P54954" /translation="MITVKNIRKAFKDLVVLDGIDLEVKRGEVVAIIGPSGSGKSTLL RCLNLLERPDQGLIEIGEAKLNAEKFTRKEAHRLRQQTAMVFQNYNLFKNKTALQNIT EALIVAQHKPRDEAKRIGMEILKQVGLEHKADSYPITMSGGQQQRIGIARALAVNPHA ILLDEPTSALDPELVTGVLQVIKSIAEKQTTMIIVTHEMAFAKEVADQVIFMADGHII EQGTPEELFDHPKNERTKRFIKQVGEPAELI*" /label="yxeO CDS" gene complement(3558914..3559663) /gene="yxeO" /locus_tag="BSU_39480" /old_locus_tag="BSU39480" /label="yxeO gene" CDS complement(3559676..3560350) /gene="yxeN" /locus_tag="BSU_39490" /old_locus_tag="BSU39490" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 15849754, 16513748, 16850406, 16885442; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_391828.1" /db_xref="EnsemblGenomes-Gn:BSU39490" /db_xref="EnsemblGenomes-Tr:CAB15985" /db_xref="GOA:P54953" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11890" /db_xref="UniProtKB/Swiss-Prot:P54953" /translation="MNTIDWEFMISAFPTLIQALPITLFMAIAAMIFAIIGGLILALI TKNKIPVLHQLSKLYISFFRGVPTLVQLFLIYYGLPQLFPEMSKMTALTAAIIGLSLK NAAYLAEIFRAALNSVDDGQLEACLSVGMTKFQAYRRIILPQAIRNAIPATGNTFIGL LKETSLAFTLGVMEMFAQGKMYASGNLKYFETYLAVAIVYWVLTIIYSILQDLFERAM SKPYRT*" /label="yxeN CDS" gene complement(3559676..3560350) /gene="yxeN" /locus_tag="BSU_39490" /old_locus_tag="BSU39490" /label="yxeN gene" CDS complement(3560373..3561167) /gene="yxeM" /locus_tag="BSU_39500" /old_locus_tag="BSU39500" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 16885442; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative ABC transporter (binding lipoprotein)" /protein_id="NP_391829.1" /db_xref="EnsemblGenomes-Gn:BSU39500" /db_xref="EnsemblGenomes-Tr:CAB15986" /db_xref="GOA:P54952" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11889" /db_xref="UniProtKB/Swiss-Prot:P54952" /translation="MKMKKWTVLVVAALLAVLSACGNGNSSSKEDDNVLHVGATGQSY PFAYKENGKLTGFDVEVMEAVAKKIDMKLDWKLLEFSGLMGELQTGKLDTISNQVAVT DERKETYNFTKPYAYAGTQIVVKKDNTDIKSVDDLKGKTVAAVLGSNHAKNLESKDPD KKINIKTYETQEGTLKDVAYGRVDAYVNSRTVLIAQIKKTGLPLKLAGDPIVYEQVAF PFAKDDAHDKLRKKVNKALDELRKDGTLKKLSEKYFNEDITVEQKH*" /label="yxeM CDS" gene complement(3560373..3561167) /gene="yxeM" /locus_tag="BSU_39500" /old_locus_tag="BSU39500" /label="yxeM gene" promotor_-35 3560739..3560748 /Source="Nicolas_upshift_promotors" /id="U3110" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1707 /SigmaFactorBS="gctttcaaggtttttcgcgtggtttgaaccgagaacggcTGC GACTGTCttgccttttaaaTCGTCTACTGATTTGAtgtctgtattgtcttttttgacg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3560760 /Source="Nicolas_upshifts" /id="U3110" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1707 /SigmaFactorBS="gctttcaaggtttttcgcgtggtttgaaccgagaacggcTGC GACTGTCttgccttttaaaTCGTCTACTGATTTGAtgtctgtattgtcttttttgacg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3560761..3560776 /Source="Nicolas_upshift_promotors" /id="U3110" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1707 /SigmaFactorBS="gctttcaaggtttttcgcgtggtttgaaccgagaacggcTGC GACTGTCttgccttttaaaTCGTCTACTGATTTGAtgtctgtattgtcttttttgacg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3561192..3561689) /gene="snaB" /locus_tag="BSU_39510" /old_locus_tag="BSU39510" /EC_number="2.3.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12193636, 16513748, 16885442, 23944997, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193636, 16513748, 16885442, 23944997, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sulfur-containing aminoacid acetyltransferase" /protein_id="NP_391830.2" /db_xref="EnsemblGenomes-Gn:BSU39510" /db_xref="EnsemblGenomes-Tr:CAB15987" /db_xref="GOA:P54951" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11888" /db_xref="UniProtKB/Swiss-Prot:P54951" /translation="MKPRYRLAVERDAEQLLELTLRAYEPIRKLGIRFAAAHADLDLV LKNIRENACYVMEEDGRIIATITLRMPWGKQPGPYGVPHIWWFAVDPDTGKKGIGTKL LQWLEETILRDTLKVPFVSLGTADKHPWLIEMYERKGYVRSGEQDLGKGHITVYMKKQ LRHDL*" /label="snaB CDS" gene complement(3561192..3561689) /gene="snaB" /locus_tag="BSU_39510" /old_locus_tag="BSU39510" /label="snaB gene" CDS complement(3561703..3563028) /gene="yxeK" /locus_tag="BSU_39520" /old_locus_tag="BSU39520" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8892809, 12193636, 15294834, 16513748, 16885442, 23944997; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative monooxygenase" /protein_id="NP_391831.1" /db_xref="EnsemblGenomes-Gn:BSU39520" /db_xref="EnsemblGenomes-Tr:CAB15988" /db_xref="GOA:P54950" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR016215" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG11887" /db_xref="UniProtKB/Swiss-Prot:P54950" /translation="MTSKKKQIKLGVFLAGTGHHVASWRHPDAPSDASMNLDYFKELA KTAERGKLDMLFLADSLSIDSKSHPNVLTRFEPFTLLSALAQVTSKIGLTATASTTYS EPFHIARQFASLDHLSNGRAGWNVVTSSIESTALNFSGEKHLEHHLRYQRAEEFVEIV KGLWDSWEEDAFIRNKETGEFFDKEKMHELNHKGEYFSVRGPLNVSRTPQGQPVIIQA GSSGDGKALAAKTAEVIFTAQNHLESAQEFYQSIKEQAAEFGRDPEKIAIMPGIFPII ADTEEAAQAKYKELQDLIIPSVGLQILQNYLGGIDLSAYPLDGPLPKLDAEASNAVKS RFKLVQEMAERDNMTIRELYKYVAGSRGHHIFVGTPEQLADKMQEWVDTKACDGFNIM PPLLPEGIEVFVDQVVPILQERGVFRKEYEGTTLREHFGLEKPVNRYAK*" /label="yxeK CDS" gene complement(3561703..3563028) /gene="yxeK" /locus_tag="BSU_39520" /old_locus_tag="BSU39520" /label="yxeK gene" promotor_-10 complement(3563105..3563124) /Source="Nicolas_upshift_promotors" /id="U3111" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.64035964035964" /psig=1 /xcortree=1742 /SigmaFactorBS="aatagaaaaaattaatcttaactcATTGACAAacgtccaaga caaAGGTACATTTTGATTTATTCatattaaacgactaggaatataggagtttattttt c" /listShort="yxeK, yxeL, yxeM, yxeN, yxeO, yxeP, yxeQ, yxeR, yxxB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3563109) /Source="Nicolas_upshifts" /id="U3111" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.64035964035964" /psig=1 /xcortree=1742 /SigmaFactorBS="aatagaaaaaattaatcttaactcATTGACAAacgtccaaga caaAGGTACATTTTGATTTATTCatattaaacgactaggaatataggagtttattttt c" /listShort="yxeK, yxeL, yxeM, yxeN, yxeO, yxeP, yxeQ, yxeR, yxxB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3563138..3563145) /Source="Nicolas_upshift_promotors" /id="U3111" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.64035964035964" /psig=1 /xcortree=1742 /SigmaFactorBS="aatagaaaaaattaatcttaactcATTGACAAacgtccaaga caaAGGTACATTTTGATTTATTCatattaaacgactaggaatataggagtttattttt c" /listShort="yxeK, yxeL, yxeM, yxeN, yxeO, yxeP, yxeQ, yxeR, yxxB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3563214..3563441) /gene="yxeJ" /locus_tag="BSU_39530" /old_locus_tag="BSU39530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_391832.2" /db_xref="EnsemblGenomes-Gn:BSU39530" /db_xref="EnsemblGenomes-Tr:CAB15989" /db_xref="SubtiList:BG11886" /db_xref="UniProtKB/Swiss-Prot:P54949" /translation="MSLINSHQSADSGLNIWSQLFFYTIVTASEWIGGLQKRRKGKGN GEILYEIIGRKLSLCFIRLSFLADIEVALVE*" /label="yxeJ CDS" gene complement(3563214..3563441) /gene="yxeJ" /locus_tag="BSU_39530" /old_locus_tag="BSU39530" /label="yxeJ gene" CDS complement(3563428..3564414) /gene="yxeI" /locus_tag="BSU_39540" /old_locus_tag="BSU39540" /EC_number="3.5.1.11" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15937167, 16511127, 18667582, 21978958" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15937167, 16511127, 18667582, 21978958; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin V amidase" /protein_id="NP_391833.2" /db_xref="EnsemblGenomes-Gn:BSU39540" /db_xref="EnsemblGenomes-Tr:CAB15990" /db_xref="GOA:P54948" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR029132" /db_xref="PDB:2OQC" /db_xref="SubtiList:BG11885" /db_xref="UniProtKB/Swiss-Prot:P54948" /translation="MCTSLTLETADRKHVLARTMDFAFQLGTEVILYPRRYSWNSEAD GRAHQTQYAFIGMGRKLGNILFADGINESGLSCAALYFPGYAEYEKTIREDTVHIVPH EFVTWVLSVCQSLEDVKEKIRSLTIVEKKLDLLDTVLPLHWILSDRTGRNLTIEPRAD GLKVYDNQPGVMTNSPDFIWHVTNLQQYTGIRPKQLESKEMGGLALSAFGQGLGTVGL PGDYTPPSRFVRAVYLKEHLEPAADETKGVTAAFQILANMTIPKGAVITEEDEIHYTQ YTSVMCNETGNYYFHHYDNRQIQKVNLFHEDLDCLEPKVFSAKAEESIHELN*" /label="yxeI CDS" gene complement(3563428..3564414) /gene="yxeI" /locus_tag="BSU_39540" /old_locus_tag="BSU39540" /label="yxeI gene" downshifts complement(3563432) /Source="Nicolas_upshifts" /id="D2046" /incds=0 /nref=7 /ntot=52 /MaxReadThrough="2.95669" /MaxDrop="3.32309" /score="23.0334771" /energy="-17.9" /TU="NA" /idTUdmin="U3113" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3563565..3563574 /Source="Nicolas_upshift_promotors" /id="U3112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1238 /SigmaFactorBS="agtggtggaaatagtagtttccagtttCGTTGCACATcacgg aagtatatTGCGTATAATGAATTTCGTCttcttccgttatcactgcgccctttggtat c" /listShort="S1520" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3563588..3563607 /Source="Nicolas_upshift_promotors" /id="U3112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1238 /SigmaFactorBS="agtggtggaaatagtagtttccagtttCGTTGCACATcacgg aagtatatTGCGTATAATGAATTTCGTCttcttccgttatcactgcgccctttggtat c" /listShort="S1520" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3563598..3564231 /Source="Nicolas_S_feature" /locus_tag="new_4062713_4063346" /HighExp="S6, S7, S8, S5, Paraq, G150, H2O2, G180, LBGexp, Oxctl" /AntisenseName="yxeI" /AntisenseCor="0.24221971906572701" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.98" /TUlongSig="NA" /TUlongPSig="NA" /label="S1520" upshifts 3563598 /Source="Nicolas_upshifts" /id="U3112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1238 /SigmaFactorBS="agtggtggaaatagtagtttccagtttCGTTGCACATcacgg aagtatatTGCGTATAATGAATTTCGTCttcttccgttatcactgcgccctttggtat c" /listShort="S1520" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3564469..3564488) /Source="Nicolas_upshift_promotors" /id="U3113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=629 /SigmaFactorBS="ttttttcgttttatttgatgtaatgtcaatTCTTTGACgaat cgatttgactTTCGTTATGCTGATAAAACCaattcgttcacaatatgtatgatattaa t" /listShort="yxeI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3564480) /Source="Nicolas_upshifts" /id="U3113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=629 /SigmaFactorBS="ttttttcgttttatttgatgtaatgtcaatTCTTTGACgaat cgatttgactTTCGTTATGCTGATAAAACCaattcgttcacaatatgtatgatattaa t" /listShort="yxeI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3564503..3564510) /Source="Nicolas_upshift_promotors" /id="U3113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=629 /SigmaFactorBS="ttttttcgttttatttgatgtaatgtcaatTCTTTGACgaat cgatttgactTTCGTTATGCTGATAAAACCaattcgttcacaatatgtatgatattaa t" /listShort="yxeI" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3564569..3565381) /gene="hadM" /locus_tag="BSU_39550" /old_locus_tag="BSU39550" /EC_number="3.1.3.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 21575135, 23582330, 25527541, 25848029, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sugar-phosphate hydrolase (promiscuous)" /protein_id="NP_391834.1" /db_xref="EnsemblGenomes-Gn:BSU39550" /db_xref="EnsemblGenomes-Tr:CAB15991" /db_xref="GOA:P54947" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11884" /db_xref="UniProtKB/Swiss-Prot:P54947" /translation="MYKLIAIDMDGTLLNDHHEVTEEVRDALHAAKAEGVKIVLCTGR PIGGVQRYLDELNLIEEGDYVIAYNGALVQNTHTNEVVSELSLGYDDLTSLYDLSLEL KTPMHFFDSSNLYTPNRDISEFTVYESYVTQVPLHFRKIDEVPKDILIPKVMFIDKPE NLSRVITSIPKDVREKYTMVRSAPFFYEILHSEASKGNAVRQLAQLLGIEQAEVMCIG DNGNDLTMIEWAGCGVAMANAIPEVLEAANFQTRSNNEHGVAHAIHELVLAK*" /label="hadM CDS" gene complement(3564569..3565381) /gene="hadM" /locus_tag="BSU_39550" /old_locus_tag="BSU39550" /label="hadM gene" promotor_-10 complement(3565411..3565430) /Source="Nicolas_upshift_promotors" /id="U3114" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.998001998001998" /xcortree=2354 /SigmaFactorBS="aagggcggcgtctaaacagaatccggagaaaaccatctcttc CGGTTGAAtatcaaaaagaaaaAACGATATGATGGGACTATAgcctgaaaacgacatg a" /listShort="yxeH" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3565421..3565978) /gene="yxeG" /locus_tag="BSU_39560" /old_locus_tag="BSU39560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391835.1" /db_xref="EnsemblGenomes-Gn:BSU39560" /db_xref="EnsemblGenomes-Tr:CAB15992" /db_xref="GOA:P54946" /db_xref="SubtiList:BG11883" /db_xref="UniProtKB/Swiss-Prot:P54946" /translation="MRNQKAERLVAAGLVLHIIQWIFILWAFLKVKHLFSDYTIYNPN VISGSMQSLSFIQMMRAMMYSGAIVNYVLFFALVLLIYGIVLHAILIVLEMAAYVMIR RNPSSSWGFFFIAAGVKLAILNITGIPFLAAGFLLMKQKKAENGVKAERKRKPRLRIR RQGRRLNRIRRKPSLPVEYQKEKTI*" /label="yxeG CDS" gene complement(3565421..3565978) /gene="yxeG" /locus_tag="BSU_39560" /old_locus_tag="BSU39560" /label="yxeG gene" upshifts complement(3565434) /Source="Nicolas_upshifts" /id="U3114" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.998001998001998" /xcortree=2354 /SigmaFactorBS="aagggcggcgtctaaacagaatccggagaaaaccatctcttc CGGTTGAAtatcaaaaagaaaaAACGATATGATGGGACTATAgcctgaaaacgacatg a" /listShort="yxeH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3565445..3565452) /Source="Nicolas_upshift_promotors" /id="U3114" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.998001998001998" /xcortree=2354 /SigmaFactorBS="aagggcggcgtctaaacagaatccggagaaaaccatctcttc CGGTTGAAtatcaaaaagaaaaAACGATATGATGGGACTATAgcctgaaaacgacatg a" /listShort="yxeH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3565959..3566393) /gene="yxeF" /locus_tag="BSU_39570" /old_locus_tag="BSU39570" /function="18: Unknown function" /experiment="publication(s) with functional evidences, PMID:11160890, 22693626" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160890, 22693626; Product type s: structure" /codon_start=1 /transl_table=11 /product="lipocalin-like lipoprotein" /protein_id="NP_391836.1" /db_xref="EnsemblGenomes-Gn:BSU39570" /db_xref="EnsemblGenomes-Tr:CAB15993" /db_xref="InterPro:IPR012674" /db_xref="InterPro:IPR021664" /db_xref="PDB:2JOZ" /db_xref="SubtiList:BG11882" /db_xref="UniProtKB/Swiss-Prot:P54945" /translation="MVIPLRNKYGILFLIAVCIMVSGCQQQKEETPFYYGTWDEGRAP GPTDGVKSATVTFTEDEVVETEVMEGRGEVQLPFMAYKVISQSTDGSIEIQYLGPYYP LKSTLKRGENGTLIWEQNGQRKTMTRIESKTGREEKDEKSKS*" /label="yxeF CDS" gene complement(3565959..3566393) /gene="yxeF" /locus_tag="BSU_39570" /old_locus_tag="BSU39570" /label="yxeF gene" promotor_-35 3566418..3566427 /Source="Nicolas_upshift_promotors" /id="U3115" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1295 /SigmaFactorBS="ctcaaggggatcaccattctttcctccttttttgggcgaatG CCGTGCCACtgtgccaatgacTACATAAGTTATAAGGAATTcacccacaaggagactg a" /listShort="yxeE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3566437 /Source="Nicolas_upshifts" /id="U3115" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1295 /SigmaFactorBS="ctcaaggggatcaccattctttcctccttttttgggcgaatG CCGTGCCACtgtgccaatgacTACATAAGTTATAAGGAATTcacccacaaggagactg a" /listShort="yxeE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3566440..3566459 /Source="Nicolas_upshift_promotors" /id="U3115" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1295 /SigmaFactorBS="ctcaaggggatcaccattctttcctccttttttgggcgaatG CCGTGCCACtgtgccaatgacTACATAAGTTATAAGGAATTcacccacaaggagactg a" /listShort="yxeE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3566453) /Source="Nicolas_upshifts" /id="U3116" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.995004995004995" /psig="0.004995004995005" /xcortree=689 /SigmaFactorBS="agctgagggctgtaatattgataagggTTCATgtgatcagTC TCCTTGTGGGTGAattccttataacttatgtagtcattggcacagtggcacggcattc g" /listShort="yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3566454..3566865) /Source="Nicolas_S_feature" /locus_tag="new_4065569_4065980_c" /HighExp="Salt, H2O2, Paraq, dia15, Oxctl, Diami, Cold, G150, Lbtran, LBGexp" /AntisenseName="yxeE" /AntisenseCor="-0.602938477548701" /AntisenseRegPval="-27.3" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.391, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1521" promotor_-10 complement(3566459..3566473) /Source="Nicolas_upshift_promotors" /id="U3116" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.995004995004995" /psig="0.004995004995005" /xcortree=689 /SigmaFactorBS="agctgagggctgtaatattgataagggTTCATgtgatcagTC TCCTTGTGGGTGAattccttataacttatgtagtcattggcacagtggcacggcattc g" /listShort="yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3566482..3566486) /Source="Nicolas_upshift_promotors" /id="U3116" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.995004995004995" /psig="0.004995004995005" /xcortree=689 /SigmaFactorBS="agctgagggctgtaatattgataagggTTCATgtgatcagTC TCCTTGTGGGTGAattccttataacttatgtagtcattggcacagtggcacggcattc g" /listShort="yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3566482..3566847 /gene="cotNE" /locus_tag="BSU_39580" /old_locus_tag="BSU39580" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10714992, 17905812, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10714992, 17905812, 19933362; Product type s: structure" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391837.1" /db_xref="EnsemblGenomes-Gn:BSU39580" /db_xref="EnsemblGenomes-Tr:CAB15994" /db_xref="SubtiList:BG11881" /db_xref="UniProtKB/Swiss-Prot:P54944" /translation="MNPYQYYSPQLPQQEPYYSHYEYNPYPQQDVYDPYQMDRQPALE RRIAALERQNEQQSRELTRLTNEDRRQNREIARIAEQVNQLSQAVERHTRRLNRLNQR LRTVENRLNIPFTAGEGGF*" /label="cotNE CDS" gene 3566482..3566847 /gene="cotNE" /locus_tag="BSU_39580" /old_locus_tag="BSU39580" /label="cotNE gene" downshifts 3566861 /Source="Nicolas_upshifts" /id="D2047" /incds=0 /nref=31 /ntot=47 /MaxReadThrough="1.46494" /MaxDrop="8.36553" /score="27.2157513" /energy="-12.2" /TU="U3115" /idTUdmin="U3115" /TUdmin="-38" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3566865..3566869) /Source="Nicolas_upshift_promotors" /id="U3117" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.390609390609391" /psig="0.390609390609391" /xcortree=290 /SigmaFactorBS="cgttttaacatataagaaatgcggaaaacgaaaccCtgagat gggagaatcgtattCCGCTttttttctttgtttcgctcagaaaccgccttcccctgca g" /listShort="S1521" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3566865) /Source="Nicolas_upshifts" /id="U3117" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.390609390609391" /psig="0.390609390609391" /xcortree=290 /SigmaFactorBS="cgttttaacatataagaaatgcggaaaacgaaaccCtgagat gggagaatcgtattCCGCTttttttctttgtttcgctcagaaaccgccttcccctgca g" /listShort="S1521" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3566867..3566953) /Source="Nicolas_S_feature" /locus_tag="new_4065982_4066068_c" /HighExp="Salt, S8, H2O2, dia15, S7, Paraq, Diami, aero, Oxctl, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1522" promotor_-10 complement(3566946..3566965) /Source="Nicolas_upshift_promotors" /id="U3118" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=2444 /SigmaFactorBS="ctacaattattttcctcagcccctctaTCTTTGAAtgaaaac ggtaaaGATTGTATACTGGGTACAAAccctttttatgtaaatgttccgttttaacata t" /listShort="S1522, S1521, yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3566953) /Source="Nicolas_upshifts" /id="U3118" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=2444 /SigmaFactorBS="ctacaattattttcctcagcccctctaTCTTTGAAtgaaaac ggtaaaGATTGTATACTGGGTACAAAccctttttatgtaaatgttccgttttaacata t" /listShort="S1522, S1521, yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3566979..3566986) /Source="Nicolas_upshift_promotors" /id="U3118" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=2444 /SigmaFactorBS="ctacaattattttcctcagcccctctaTCTTTGAAtgaaaac ggtaaaGATTGTATACTGGGTACAAAccctttttatgtaaatgttccgttttaacata t" /listShort="S1522, S1521, yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3567026..3567032 /Source="Nicolas_upshift_promotors" /id="U3119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.97002997002997" /psig="0.97002997002997" /xcortree=861 /SigmaFactorBS="ggctgaggaaaataattgtagttcctctttgacGGAATTTct tttcattcaagTTGCATGATAATaccgactcacgtcaatcgatacatggagggatcat t" /listShort="yxeD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3567046..3567057 /Source="Nicolas_upshift_promotors" /id="U3119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.97002997002997" /psig="0.97002997002997" /xcortree=861 /SigmaFactorBS="ggctgaggaaaataattgtagttcctctttgacGGAATTTct tttcattcaagTTGCATGATAATaccgactcacgtcaatcgatacatggagggatcat t" /listShort="yxeD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3567053 /Source="Nicolas_upshifts" /id="U3119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.97002997002997" /psig="0.97002997002997" /xcortree=861 /SigmaFactorBS="ggctgaggaaaataattgtagttcctctttgacGGAATTTct tttcattcaagTTGCATGATAATaccgactcacgtcaatcgatacatggagggatcat t" /listShort="yxeD" /GFF_Attribute="listLong" /label="upshifts" CDS 3567095..3567448 /gene="yxeD" /locus_tag="BSU_39590" /old_locus_tag="BSU39590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 26506528" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391838.2" /db_xref="EnsemblGenomes-Gn:BSU39590" /db_xref="EnsemblGenomes-Tr:CAB15995" /db_xref="SubtiList:BG11880" /db_xref="UniProtKB/Swiss-Prot:P54943" /translation="MHNTQHGLQQLNQCRQTAQQLIQQTQQSSQQYRQMLHQEQQNIQ MLQQILNHEQQAAHTIQQALHGHDMAIQKCQQVVNMCNQMQQELTGQSSVMNTNVSTL PFGQNTTFQQQSYQQ*" /label="yxeD CDS" gene 3567095..3567448 /gene="yxeD" /locus_tag="BSU_39590" /old_locus_tag="BSU39590" /label="yxeD gene" downshifts 3567443 /Source="Nicolas_upshifts" /id="D2048" /incds=0 /nref=24 /ntot=55 /MaxReadThrough="0.20641" /MaxDrop="6.88486" /score="27.2157513" /energy="-12.2" /TU="NA" /idTUdmin="U3119" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(3567492..3567890) /gene="yxeC" /locus_tag="BSU_39600" /old_locus_tag="BSU39600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391839.2" /db_xref="EnsemblGenomes-Gn:BSU39600" /db_xref="EnsemblGenomes-Tr:CAB15996" /db_xref="GOA:P54942" /db_xref="SubtiList:BG11879" /db_xref="UniProtKB/Swiss-Prot:P54942" /translation="MGITKRGAAWEWLHSWWMLFIFMPFAITSFFAFLFIGIKVRNRK WIMYGIIYFFIFAFGFVLPDLPGVFIVVPLWAVTIIHGFKVRPLYLIQLDVYKDHVEA RAFAEARSEAESRFHAPKQSIQDIHIRKEQ*" /label="yxeC CDS" gene complement(3567492..3567890) /gene="yxeC" /locus_tag="BSU_39600" /old_locus_tag="BSU39600" /label="yxeC gene" downshifts complement(3567500) /Source="Nicolas_upshifts" /id="D2049" /incds=0 /nref=145 /ntot=243 /MaxReadThrough="1.70512" /MaxDrop="5.26494" /score="9.81431167" /energy="-12.2" /TU="NA" /idTUdmin="U3120" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3567905..3567924) /Source="Nicolas_upshift_promotors" /id="U3120" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.602397602397602" /psig="0.999000999001" /xcortree=2316 /SigmaFactorBS="tatcactatttttaagggagaaagtttttcccgtttatgGGT GacgcggtgtgcctaATCGATTATTATAGGTAAATaggaggagaaaaatatgggaatt a" /listShort="yxeC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3567921) /Source="Nicolas_upshifts" /id="U3120" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.602397602397602" /psig="0.999000999001" /xcortree=2316 /SigmaFactorBS="tatcactatttttaagggagaaagtttttcccgtttatgGGT GacgcggtgtgcctaATCGATTATTATAGGTAAATaggaggagaaaaatatgggaatt a" /listShort="yxeC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3567939..3567942) /Source="Nicolas_upshift_promotors" /id="U3120" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.602397602397602" /psig="0.999000999001" /xcortree=2316 /SigmaFactorBS="tatcactatttttaagggagaaagtttttcccgtttatgGGT GacgcggtgtgcctaATCGATTATTATAGGTAAATaggaggagaaaaatatgggaatt a" /listShort="yxeC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3567978..3567985 /Source="Nicolas_upshift_promotors" /id="U3121" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig=1 /xcortree=2105 /SigmaFactorBS="cgggaaaaactttctcccttaaaaatagtGATAGACGgagaa caggtttctTGCTATATTATTAATTGATAatgataatcattactaatctattgagata c" /listShort="yxeB, S1523" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3567994..3568012) /Source="Nicolas_upshift_promotors" /id="U3122" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=775 /SigmaFactorBS="atcaagaaccctcccactatgtatctcaatagattaGTAATG attatcattatcaatTAATAATATAGCAAGAAACctgttctccgtctatcactatttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 3568000..3568019 /Source="Nicolas_upshift_promotors" /id="U3121" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig=1 /xcortree=2105 /SigmaFactorBS="cgggaaaaactttctcccttaaaaatagtGATAGACGgagaa caggtttctTGCTATATTATTAATTGATAatgataatcattactaatctattgagata c" /listShort="yxeB, S1523" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3568009 /Source="Nicolas_upshifts" /id="U3121" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig=1 /xcortree=2105 /SigmaFactorBS="cgggaaaaactttctcccttaaaaatagtGATAGACGgagaa caggtttctTGCTATATTATTAATTGATAatgataatcattactaatctattgagata c" /listShort="yxeB, S1523" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3568009) /Source="Nicolas_upshifts" /id="U3122" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=775 /SigmaFactorBS="atcaagaaccctcccactatgtatctcaatagattaGTAATG attatcattatcaatTAATAATATAGCAAGAAACctgttctccgtctatcactatttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3568028..3568033) /Source="Nicolas_upshift_promotors" /id="U3122" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=775 /SigmaFactorBS="atcaagaaccctcccactatgtatctcaatagattaGTAATG attatcattatcaatTAATAATATAGCAAGAAACctgttctccgtctatcactatttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3568068..3569033 /gene="frxB" /locus_tag="BSU_39610" /old_locus_tag="BSU39610" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12354229, 16672620, 8388528, 19254027, 23924612, 25007174; Product type t : transporter" /codon_start=1 /transl_table=11 /product="desferrioxamine-and ferrichrome-binding transporter lipoprotein (shuttle system)" /protein_id="NP_391840.2" /db_xref="EnsemblGenomes-Gn:BSU39610" /db_xref="EnsemblGenomes-Tr:CAB15997" /db_xref="GOA:P54941" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG11878" /db_xref="UniProtKB/Swiss-Prot:P54941" /translation="MKKNILLVGMLVLLLMFVSACSGTASKGSSSDSASEKTEMRTYK SPKGNVNIPAHPKRIVTDFYAGELLSVGANVVGSGSWSFDNPFLKSKLKNVKDVGDPI SVEKVMELQPDLIVVMNEENVDKLKKIAPTVVIPYNTAKNVEDTVSMFGDIAGAKDQA KSFMADFNKKAEAAKKKIAGVIDKDATFGIYENTDKGEFWVFNDNGGRGGQAVYNALG LKAPEKIEQDVIKKGEMKQLSQEVIPEYAADYMFITDYNPKGESKTLDKLENSSIWKN LDAVKHNRVFINDFDSFYPYDPISVSKQVDIITDMLIKRAEENKK*" /label="frxB CDS" gene 3568068..3569033 /gene="frxB" /locus_tag="BSU_39610" /old_locus_tag="BSU39610" /label="frxB gene" upshifts 3568461 /Source="Nicolas_upshifts" /id="U3123" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.726273726273726" /psig="0.726273726273726" /xcortree=773 /SigmaFactorBS="cctgacttaattgttgtcatgaatgaagagaatgttgataaa ttaaagaaaatcgctccgactgttgTCATACCTTATAACACAGCgaaaaacgtagaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3568468..3568486 /Source="Nicolas_upshift_promotors" /id="U3123" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.726273726273726" /psig="0.726273726273726" /xcortree=773 /SigmaFactorBS="cctgacttaattgttgtcatgaatgaagagaatgttgataaa ttaaagaaaatcgctccgactgttgTCATACCTTATAACACAGCgaaaaacgtagaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts 3568940 /Source="Nicolas_upshifts" /id="D2050" /incds=1 /nref=55 /ntot=191 /MaxReadThrough="6.103" /MaxDrop="4.3334" /score="22.3558496" /energy="-13.4" /TU="U3121" /idTUdmin="U3123" /TUdmin=193 /isTUend="FALSE" /label="downshifts" downshifts 3569011 /Source="Nicolas_upshifts" /id="D2051" /incds=0 /nref=1 /ntot=62 /MaxReadThrough="4.41732" /MaxDrop="3.7101" /score="22.3558496" /energy="-13.4" /TU="U3121" /idTUdmin="U3123" /TUdmin=264 /isTUend="FALSE" /label="downshifts" S_feature 3569056..3569852 /Source="Nicolas_S_feature" /locus_tag="new_4068171_4068967" /HighExp="H2O2, Paraq, Lbexp, dia0, LBGexp, G150, B36, dia15, B60, GM 25" /AntisenseName="yxeA" /AntisenseCor="0.20524492145617201" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1523" CDS complement(3569074..3569421) /gene="yxeA" /locus_tag="BSU_39620" /old_locus_tag="BSU39620" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391841.1" /db_xref="EnsemblGenomes-Gn:BSU39620" /db_xref="EnsemblGenomes-Tr:CAB15998" /db_xref="InterPro:IPR006542" /db_xref="InterPro:IPR036166" /db_xref="PDB:3NPP" /db_xref="SubtiList:BG11877" /db_xref="UniProtKB/Swiss-Prot:P54940" /translation="MKKAMAILAVLAAAAVICGLLFFHNDVTDRFNPFIHQQDVYVQI DRDGRHLSPGGTEYTLDGYNASGKKEEVTFFAGKELRKNAYLKVKAKGKYVETWEEVK FEDMPDSVQSKLK*" /label="yxeA CDS" gene complement(3569074..3569421) /gene="yxeA" /locus_tag="BSU_39620" /old_locus_tag="BSU39620" /label="yxeA gene" downshifts complement(3569087) /Source="Nicolas_upshifts" /id="D2052" /incds=0 /nref=2 /ntot=78 /MaxReadThrough="1.28842" /MaxDrop="2.99568" /score="38.5550476" /energy="-11.6" /TU="NA" /idTUdmin="U3120" /TUdmin="-1584" /isTUend="FALSE" /label="downshifts" CDS complement(3569435..3571303) /gene="tpeM" /locus_tag="BSU_39630" /old_locus_tag="BSU39630" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15289557, 15849754, 15870467, 16850406, 21078927, 28472044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15289557, 15849754, 15870467, 16850406, 21078927, 28472044; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease); efflux of cationic peptides" /protein_id="NP_391842.2" /db_xref="EnsemblGenomes-Gn:BSU39630" /db_xref="EnsemblGenomes-Tr:CAB15999" /db_xref="GOA:P42424" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR027022" /db_xref="SubtiList:BG11129" /db_xref="UniProtKB/Swiss-Prot:P42424" /translation="MTFLQFAYKNVTRNKRAYLAFFLSSAFSVLIFFTFAMFLFHPAL KEGYLNNIAKKGLTAAEWMIFVFSFLFVLYSVNAFLKSRNKEFGILLMQGITPGQLRK LITAENMIIGVMSIAAGIIGGFIFSKTFFTVGAYILEMDALPLYMPWKALGITACGFL LLFFFLSQFTILFVRSNTVIKLIKGTGKVKPEPKPSVLLSLFGIACLCGGYGMVLKGN VHGAEPFIILLLTVIGTYFFFSQSSIWILRALKKWKTFYLRGKNIIWVSDLVYRLKDN ARLFFIVSIISAVAFTATGVLAMYKSTVGAEESAYEMEYLSYSNNPKEQTHLKDIDHE LKTHGFTYTKDKIDVSYVRYQEGETVPPVYMISESDAAKYFHVKVNGLKEDEAVYFPG TYDRNFKNEAPDQLKLLNQKGELSDQKLSVKEVKKPLISLNAIIAVNDQTFDQLKSLG DKASLYGYSYDHWKDSLEISQSLQNEIYGNYIDVHSDFASKAGTYYDTVQLPSLSLFI GLFIAIVFFVAAASFLYFRLFTDLDEDRERYRSLAKIGLSEREMAQSVTIQLAILFFF PFVIAVMHTLFALRTLAVEGYSDVAGPLSLTIGGFFIFQLLFFLAVRSSYLKKMNK*" /label="tpeM CDS" gene complement(3569435..3571303) /gene="tpeM" /locus_tag="BSU_39630" /old_locus_tag="BSU39630" /label="tpeM gene" CDS complement(3571278..3572051) /gene="tpeL" /locus_tag="BSU_39640" /old_locus_tag="BSU39640" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15289557, 15870467, 17600057, 21078927, 28472044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15289557, 15870467, 17600057, 21078927, 28472044; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein); efflux ofcationic peptides" /protein_id="NP_391843.2" /db_xref="EnsemblGenomes-Gn:BSU39640" /db_xref="EnsemblGenomes-Tr:CAB16000" /db_xref="GOA:P42423" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11128" /db_xref="UniProtKB/Swiss-Prot:P42423" /translation="MANMLEVKHINKTYKGQVSYQALKQISFSIEEGEFTAVMGPSGS GKTTLLNIISTIDRPDSGDILINGENPHRLKRTKLAHFRRKQLGFVFQDFNLLDTLTI GENIMLPLTLEKEAPSVMEEKLHGIAAKLGIENLLNKRTFEVSGGQRQRAAIARAVIH KPSLILADEPTGNLDSKATKDVMETLQSLNRDDHVTALMVTHDPVSASYCRRVIFIKD GELFNEIYRGENRQVFYEQILDVLSMLGGNANDLSSVRL*" /label="tpeL CDS" gene complement(3571278..3572051) /gene="tpeL" /locus_tag="BSU_39640" /old_locus_tag="BSU39640" /label="tpeL gene" CDS complement(3572195..3573172) /gene="tpeK" /locus_tag="BSU_39650" /old_locus_tag="BSU39650" /EC_number="2.7.13.3" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15289557, 15870467, 21283517, 25875741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15289557, 15870467, 21283517, 25875741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YxdJ]" /protein_id="NP_391844.1" /db_xref="EnsemblGenomes-Gn:BSU39650" /db_xref="EnsemblGenomes-Tr:CAB16001" /db_xref="GOA:P42422" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11127" /db_xref="UniProtKB/Swiss-Prot:P42422" /translation="MKLFLRSHAVLILLFLLQGLFVFFYYWFAGLHSFSHLFYILGVQ LLILAGYLAYRWYKDRGVYHWLSSGQEGTDIPYLGSSVFCSELYEKQMELIRLQHQKL HETEAKLDARVTYMNQWVHQVKTPLSVINLIIQEEDEPVFEQIKKEVRQIEFGLETLL YSSRLDLFERDFKIEAVSLSELLQSVIQSYKRFFIQYRVYPKMNVCDDHQIYTDAKWL KFAIGQVVTNAVKYSAGKSDRLELNVFCDEDRTVLEVKDYGVGIPSQDIKRVFDPYYT GENGRRFQESTGIGLHLVKEITDKLNHTVDISSSPGEGTSVRFSFLTKM*" /label="tpeK CDS" gene complement(3572195..3573172) /gene="tpeK" /locus_tag="BSU_39650" /old_locus_tag="BSU39650" /label="tpeK gene" CDS complement(3573169..3573858) /gene="tpeJ" /locus_tag="BSU_39660" /old_locus_tag="BSU39660" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15289557, 15870467, 21283517, 25875741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15289557, 15870467, 21283517, 25875741; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [TpeK(YxdK)]" /protein_id="NP_391845.1" /db_xref="EnsemblGenomes-Gn:BSU39660" /db_xref="EnsemblGenomes-Tr:CAB16002" /db_xref="GOA:P42421" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11126" /db_xref="UniProtKB/Swiss-Prot:P42421" /translation="MNKIMIVEDSEDIRGLLQNYLEKYGYQTVVAADFTAVLDVFLRE KPDVVLLDINLPAYDGYYWCRQIRQHSTSPIIFISARSGEMDQVMAIENGGDDYIEKP FSYDIVLAKIKSQIRRAYGEYAAKQGEKVVEYAGVQLFVERFELRFQDEKSELSKKES KLLEVLLERGEKVTSRDRLMEKTWDTDIFIDDNTLNVYITRLRKKLRELNAPVSIEAV RGEGYQLRAQS*" /label="tpeJ CDS" gene complement(3573169..3573858) /gene="tpeJ" /locus_tag="BSU_39660" /old_locus_tag="BSU39660" /label="tpeJ gene" promotor_-10 complement(3573885..3573904) /Source="Nicolas_upshift_promotors" /id="U3124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.440559440559441" /psig="0.963036963036963" /xcortree=1786 /SigmaFactorBS="agaccagaaaccgccgagatggcggtttttttgtgcggTGTT GCGtccatacgcccaaaACGATTATGATGATGGCAGCagtgtaagaaacgggagtggt t" /listShort="yxdJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3573903) /Source="Nicolas_upshifts" /id="U3124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.440559440559441" /psig="0.963036963036963" /xcortree=1786 /SigmaFactorBS="agaccagaaaccgccgagatggcggtttttttgtgcggTGTT GCGtccatacgcccaaaACGATTATGATGATGGCAGCagtgtaagaaacgggagtggt t" /listShort="yxdJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3573919..3573925) /Source="Nicolas_upshift_promotors" /id="U3124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.440559440559441" /psig="0.963036963036963" /xcortree=1786 /SigmaFactorBS="agaccagaaaccgccgagatggcggtttttttgtgcggTGTT GCGtccatacgcccaaaACGATTATGATGATGGCAGCagtgtaagaaacgggagtggt t" /listShort="yxdJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3573966..3574838) /gene="iolJ" /locus_tag="BSU_39670" /old_locus_tag="BSU39670" /EC_number="4.1.2.29" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9226270, 10658656, 11325924, 18310071" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9226270, 10658656, 11325924, 18310071; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-deoxy-5-keto-D-gluconic acid 6-phosphate aldolase" /protein_id="NP_391846.1" /db_xref="EnsemblGenomes-Gn:BSU39670" /db_xref="EnsemblGenomes-Tr:CAB16003" /db_xref="GOA:P42420" /db_xref="InterPro:IPR000771" /db_xref="InterPro:IPR011289" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG11125" /db_xref="UniProtKB/Swiss-Prot:P42420" /translation="MAFVSMKELLEDAKREQYAIGQFNINGLQWTKAILQAAQKEQSP VIAAASDRLVDYLGGFKTIAAMVGALIEDMAITVPVVLHLDHGSSAERCRQAIDAGFS SVMIDGSHQPIDENIAMTKEVTDYAAKHGVSVEAEVGTVGGMEDGLVGGVRYADITEC ERIVKETNIDALAAALGSVHGKYQGEPNLGFKEMEAISRMTDIPLVLHGASGIPQDQI KKAITLGHAKININTECMVAWTDETRRMFQENSDLYEPRGYLTPGIEAVEETVRSKMR EFGSAGKAAKQQVG*" /label="iolJ CDS" gene complement(3573966..3574838) /gene="iolJ" /locus_tag="BSU_39670" /old_locus_tag="BSU39670" /label="iolJ gene" downshifts complement(3573970) /Source="Nicolas_upshifts" /id="D2053" /incds=0 /nref=89 /ntot=172 /MaxReadThrough="3.05314" /MaxDrop="6.87265" /score="26.7325466" /energy="-8.2" /TU="NA" /idTUdmin="U3126" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3574859..3575695) /gene="iolI" /locus_tag="BSU_39680" /old_locus_tag="BSU39680" /EC_number="5.3.99.11" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 17619021, 16461681, 18310071, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 17619021, 16461681, 18310071, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inosose isomerase" /protein_id="NP_391847.1" /db_xref="EnsemblGenomes-Gn:BSU39680" /db_xref="EnsemblGenomes-Tr:CAB16004" /db_xref="GOA:P42419" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR036237" /db_xref="PDB:1I60" /db_xref="PDB:1I6N" /db_xref="SubtiList:BG11124" /db_xref="UniProtKB/Swiss-Prot:P42419" /translation="MKLCFNEATTLENSNLKLDLELCEKHGYDYIEIRTMDKLPEYLK DHSLDDLAEYFQTHHIKPLALNALVFFNNRDEKGHNEIITEFKGMMETCKTLGVKYVV AVPLVTEQKIVKEEIKKSSVDVLTELSDIAEPYGVKIALEFVGHPQCTVNTFEQAYEI VNTVNRDNVGLVLDSFHFHAMGSNIESLKQADGKKIFIYHIDDTEDFPIGFLTDEDRV WPGQGAIDLDAHLSALKEIGFSDVVSVELFRPEYYKLTAEEAIQTAKKTTVDVVSKYF SM*" /label="iolI CDS" gene complement(3574859..3575695) /gene="iolI" /locus_tag="BSU_39680" /old_locus_tag="BSU39680" /label="iolI gene" S_feature complement(3575696..3575780) /Source="Nicolas_S_feature" /locus_tag="new_4074811_4074895_c" /HighExp="M40t90, M0t90, BI, Sw, BC, T5.0H, T0.30H, T4.0H, T3.30H, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.101524" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1524" CDS complement(3575781..3576650) /gene="iolH" /locus_tag="BSU_39690" /old_locus_tag="BSU39690" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9887260, 11566986, 12112707, 23874669; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar-phosphate epimerase/isomerase" /protein_id="NP_391848.1" /db_xref="EnsemblGenomes-Gn:BSU39690" /db_xref="EnsemblGenomes-Tr:CAB16005" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11123" /db_xref="UniProtKB/Swiss-Prot:P42418" /translation="MKLALDPSMYRDDLTLEEMVYKTAELGYEYIELSPREDFCPFYK YPKVDSAKIKQLKRLLRDTGVKLSSLLPLYHWAGPDEDRRQAAVRNWKRAIEIAVELE VDLMNSEFSGSKYDPLTSEEKFIKSMDELLPVFEKEGIKLNLQAHPYDFIETHKGAMD MIRALDKDWINLVYSTAHTFFYDDGKGDIETMFDEAGDRLTHVLFADTYNHKAAHGLR YIVNPPDAKVTVHQHLDIGQGEVDFDTIFRKLREMKFDGIATNAVFAWVDERADESSR FMLKKMKEELGLA*" /label="iolH CDS" gene complement(3575781..3576650) /gene="iolH" /locus_tag="BSU_39690" /old_locus_tag="BSU39690" /label="iolH gene" CDS complement(3576670..3577704) /gene="iolG" /locus_tag="BSU_39700" /old_locus_tag="BSU39700" /EC_number="1.1.1.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:112095, 11274120, 15678175, 9226270, 16461681, 18310071, 22720735, 25482235, 28431560" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 112095, 11274120, 15678175, 9226270, 16461681, 18310071, 22720735, 25482235, 28431560; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="myo-inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase" /protein_id="NP_391849.2" /db_xref="EnsemblGenomes-Gn:BSU39700" /db_xref="EnsemblGenomes-Tr:CAB16006" /db_xref="GOA:P26935" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR023794" /db_xref="InterPro:IPR036291" /db_xref="PDB:3MZ0" /db_xref="PDB:3NT2" /db_xref="PDB:3NT4" /db_xref="PDB:3NT5" /db_xref="PDB:3NTO" /db_xref="PDB:3NTQ" /db_xref="PDB:3NTR" /db_xref="PDB:4L8V" /db_xref="PDB:4L9R" /db_xref="SubtiList:BG10669" /db_xref="UniProtKB/Swiss-Prot:P26935" /translation="MSLRIGVIGTGAIGKEHINRITNKLSGAEIVAVTDVNQEAAQKV VEQYQLNATVYPNDDSLLADENVDAVLVTSWGPAHESSVLKAIKAQKYVFCEKPLATT AEGCMRIVEEEIKVGKRLVQVGFMRRYDSGYVQLKEALDNHVIGEPLMIHCAHRNPTV GDNYTTDMAVVDTLVHEIDVLHWLVNDDYESVQVIYPKKSKNALPHLKDPQIVVIETK GGIVINAEIYVNCKYGYDIQCEIVGEDGIIKLPEPSSISLRKEGRFSTDILMDWQRRF VAAYDVEIQDFIDSIQKKGEVSGPTAWDGYIAAVTTDACVKAQESGQKEKVELKEKPE FYQSFTTVQN*" /label="iolG CDS" gene complement(3576670..3577704) /gene="iolG" /locus_tag="BSU_39700" /old_locus_tag="BSU39700" /label="iolG gene" CDS complement(3577727..3579043) /gene="iolF" /locus_tag="BSU_39710" /old_locus_tag="BSU39710" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11807058, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11807058, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="inositol transport protein" /protein_id="NP_391850.2" /db_xref="EnsemblGenomes-Gn:BSU39710" /db_xref="EnsemblGenomes-Tr:CAB16007" /db_xref="GOA:P42417" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11122" /db_xref="UniProtKB/Swiss-Prot:P42417" /translation="MGNTNGDSAFNKRTIAAALANYIDAGSIVAGSAGLSLWVSYLKL SDTQIGLLGALSANAISAAVGALLGGFLADKVGRKAVYTNSMLVYALGICLVLFGVNF PMLLSGYIIIGLSVGADITASWTIIAENAPKKNRARHCGVAQVAWAAGAVVVLLLSVL AGDLGLLGNKIVFAHLLVIALITYILRIRLPESDAWQTKNQPEEAQAEKPAVLNKTSY FDLLKPMYLKSILFLMGVYLVWNLAAGVMGFFMPYIYQQVGGVSANMANLLQMGLFIF TGLGVALIFMPFADKYRKTVFGIAAFMAVIGWTLFLLPVEGLPILLLFIVVIGINNGA GQQANYQLWASEIFPTQYRASAQGLMFFLVRISIGIWSLFVPMIITNFGIGTMAAILL GCVTASMIIGLLFAPNTSGKSLEQIQEELYGSPQSQVKKGTESKIM*" /label="iolF CDS" gene complement(3577727..3579043) /gene="iolF" /locus_tag="BSU_39710" /old_locus_tag="BSU39710" /label="iolF gene" CDS complement(3579058..3579951) /gene="iolE" /locus_tag="BSU_39720" /old_locus_tag="BSU39720" /EC_number="4.2.1.44" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9226270, 14993306, 22720735, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9226270, 14993306, 22720735, 28693424; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inosose dehydratase" /protein_id="NP_391851.1" /db_xref="EnsemblGenomes-Gn:BSU39720" /db_xref="EnsemblGenomes-Tr:CAB16008" /db_xref="GOA:P42416" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR023952" /db_xref="InterPro:IPR030823" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11121" /db_xref="UniProtKB/Swiss-Prot:P42416" /translation="MGKNEILWGIAPIGWRNDDMPEIGAGNTLQHLLSDIVVARFQGT EVGGFFPEPAILNKELKLRNLRIAGKWFSSFILRDGLGEAAKTFTLHCEYLQQVNADV AVVSEQTYSVQSLEKNVFTEKPHFTDDEWERLCEGLNHLGEIAAQHGLKLVYHHHLGT GVQTAEEVDRLMAGTDPAHVHLLYDTGHAYISDGDYMGMLEKHIGRIKHVHFKDARLN VMEQCRLEGQSFRQSFLKGMFTVPGDGCIDFREVYQLLLKHSYSGWIVIEAEQDPDVA NPLEYALIARNYIDQQLLDLA*" /label="iolE CDS" gene complement(3579058..3579951) /gene="iolE" /locus_tag="BSU_39720" /old_locus_tag="BSU39720" /label="iolE gene" CDS complement(3579968..3581881) /gene="iolD" /locus_tag="BSU_39730" /old_locus_tag="BSU39730" /EC_number="3.7.1.22" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 18310071, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 18310071, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase" /protein_id="NP_391852.2" /db_xref="EnsemblGenomes-Gn:BSU39730" /db_xref="EnsemblGenomes-Tr:CAB16009" /db_xref="GOA:P42415" /db_xref="InterPro:IPR000399" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR023757" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR030817" /db_xref="SubtiList:BG11120" /db_xref="UniProtKB/Swiss-Prot:P42415" /translation="MGKKIRLTTAQALIKFLNQQYIHVDGKEEPFVEGIFTIFGHGNV LGIGQALEQDAGHLKVYQGKNEQGMAHAAMAYSKQMLRRKIYAVSTSVGPGAANLVAA AGTALANNIPVLLIPADTFATRQPDPVLQQMEQEYSAAITTNDALKPVSRYWDRITRP EQLMSSLLRAFEVMTDPAKAGPATICISQDVEGEAYDFDESFFVKRVHYIDRMQPSER ELQGAAELIKSSKKPVILVGGGAKYSGARDELVAISEAYNIPLVETQAGKSTVEADFA NNLGGMGITGTLAANKAARQADLIIGIGTRYTDFATSSKTAFDFDKAKFLNINVSRMQ AYKLDAFQVVADAKVTLGKLHGLLEGYESEFGTTIRELKDEWLAERERLSKVTFKREA FDPEIKNHFSQEVLNEYADALNTELPQTTALLTINETIPEDSVIICSAGSLPGDLQRL WHSNVPNTYHLEYGYSCMGYEVSGTLGLKLAHPDREVYSIVGDGSFLMLHSELITAIQ YNKKINVLLFDNSGFGCINNLQMDHGSGSYYCEFRTDDNQILNVDYAKVAEGYGAKTY RANTVEELKAALEDAKKQDVSTLIEMKVLPKTMTDGYDSWWHVGVAEVSEQESVQKAY EAKEKKLESAKQY*" /label="iolD CDS" gene complement(3579968..3581881) /gene="iolD" /locus_tag="BSU_39730" /old_locus_tag="BSU39730" /label="iolD gene" CDS complement(3581914..3582891) /gene="iolC" /locus_tag="BSU_39740" /old_locus_tag="BSU39740" /EC_number="2.7.1.92" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 18310071, 22720735, 23874669" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 18310071, 22720735, 23874669; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="2-deoxy-5-keto-D-gluconic acid kinase" /protein_id="NP_391853.1" /db_xref="EnsemblGenomes-Gn:BSU39740" /db_xref="EnsemblGenomes-Tr:CAB16010" /db_xref="GOA:P42414" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR022841" /db_xref="InterPro:IPR023314" /db_xref="InterPro:IPR029056" /db_xref="InterPro:IPR030830" /db_xref="SubtiList:BG11119" /db_xref="UniProtKB/Swiss-Prot:P42414" /translation="MKYTFNEEKAFDIVAIGRACIDLNAVEYNRPMEETMTFSKYVGG SPANIAIGSAKLGLKAGFIGKIPDDQHGRFIESYMRKTGVDTTQMIVDQDGHKAGLAF TEILSPEECSILMYRDDVADLYLEPSEVSEDYIANAKMLLVSGTALAKSPSREAVLKA VQYAKKHQVKVVFELDYRPYTWQSSDETAVYYSLVAEQSDIVIGTRDEFDVMENRTGG SNEESVNHLFGHSADLVVIKHGVEGSYAYSKSGEVFRAQAYKTKVLKTFGAGDSYASA FIYGLVSGKDIETALKYGSASASIVVSKHSSSEAMPTAEEIEQLIEAQS*" /label="iolC CDS" gene complement(3581914..3582891) /gene="iolC" /locus_tag="BSU_39740" /old_locus_tag="BSU39740" /label="iolC gene" CDS complement(3582915..3583730) /gene="iolB" /locus_tag="BSU_39750" /old_locus_tag="BSU39750" /EC_number="5.3.1.30" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 18310071, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 18310071, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-deoxy-D-glucuronic acid isomerase" /protein_id="NP_391854.2" /db_xref="EnsemblGenomes-Gn:BSU39750" /db_xref="EnsemblGenomes-Tr:CAB16011" /db_xref="GOA:P42413" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR021120" /db_xref="InterPro:IPR023770" /db_xref="InterPro:IPR024203" /db_xref="SubtiList:BG11118" /db_xref="UniProtKB/Swiss-Prot:P42413" /translation="MSYLLRKPQSHEVSNGVKLVHEVTTSNSDLTYVEFKVLDLASGS SYTEELKKQEICIVAVTGKITVTDHESTFENIGTRESVFERKPTDSVYISNDRAFEIT AVSDARVALCYSPSEKQLPTKLIKAEDNGIEHRGQFSNKRTVHNILPDSDPSANSLLV VEVYTDSGNWSSYPPHKHDQDNLPEESFLEETYYHELDPGQGFVFQRVYTDDRSIDET MTVGNENVVIVPAGYHPVGVPDGYTSYYLNVMAGPTRKWKFYNDPAHEWILER*" /label="iolB CDS" gene complement(3582915..3583730) /gene="iolB" /locus_tag="BSU_39750" /old_locus_tag="BSU39750" /label="iolB gene" S_feature complement(3583731..3583804) /Source="Nicolas_S_feature" /locus_tag="new_4082846_4082919_c" /HighExp="M40t90, M0t90, Lbtran, BI, Mt0, T0.30H, Sw, BC, S1, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1525" CDS complement(3583805..3585268) /gene="iolA" /locus_tag="BSU_39760" /old_locus_tag="BSU39760" /EC_number="1.2.1.27" /EC_number="1.2.1.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10658656, 11566986, 16332250, 18310071, 20971862, 22720735, 26832667" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658656, 11566986, 16332250, 18310071, 20971862, 22720735, 26832667; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylmalonate-semialdehyde dehydrogenase" /protein_id="NP_391855.1" /db_xref="EnsemblGenomes-Gn:BSU39760" /db_xref="EnsemblGenomes-Tr:CAB16012" /db_xref="GOA:P42412" /db_xref="InterPro:IPR010061" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR023510" /db_xref="PDB:1T90" /db_xref="SubtiList:BG11117" /db_xref="UniProtKB/Swiss-Prot:P42412" /translation="MAEIRKLKNYINGEWVESKTDQYEDVVNPATKEVLCQVPISTKE DIDYAAQTAAEAFKTWSKVAVPRRARILFNFQQLLSQHKEELAHLITIENGKNTKEAL GEVGRGIENVEFAAGAPSLMMGDSLASIATDVEAANYRYPIGVVGGIAPFNFPMMVPC WMFPMAIALGNTFILKPSERTPLLTEKLVELFEKAGLPKGVFNVVYGAHDVVNGILEH PEIKAISFVGSKPVGEYVYKKGSENLKRVQSLTGAKNHTIVLNDANLEDTVTNIVGAA FGSAGERCMACAVVTVEEGIADEFMAKLQEKVADIKIGNGLDDGVFLGPVIREDNKKR TLSYIEKGLEEGARLVCDGRENVSDDGYFVGPTIFDNVTTEMTIWKDEIFAPVLSVIR VKNLKEAIEIANKSEFANGACLFTSNSNAIRYFRENIDAGMLGINLGVPAPMAFFPFS GWKSSFFGTLHANGKDSVDFYTRKKVVTARYPAPDFN*" /label="iolA CDS" gene complement(3583805..3585268) /gene="iolA" /locus_tag="BSU_39760" /old_locus_tag="BSU39760" /label="iolA gene" S_feature complement(3585269..3585473) /Source="Nicolas_S_feature" /locus_tag="new_4084384_4084588_c" /HighExp="M0t90, M40t90, Lbtran, BI, Mt0, T0.30H, BC, S1, T1.0H, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1526" promotor_-35 3585272..3585279 /Source="Nicolas_upshift_promotors" /id="U3125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.788211788211788" /xcortree=1805 /SigmaFactorBS="gttttttaattttctgatttctgccattctTATTGCCTcctt cattagtaaacACATACACTTGTATGGATGGttccggatagattcatatcaatatcca c" /listShort="S1527" /listLong="iolR, iolS" /label="promotor_-35" promotor_-10 3585295..3585314 /Source="Nicolas_upshift_promotors" /id="U3125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.788211788211788" /xcortree=1805 /SigmaFactorBS="gttttttaattttctgatttctgccattctTATTGCCTcctt cattagtaaacACATACACTTGTATGGATGGttccggatagattcatatcaatatcca c" /listShort="S1527" /listLong="iolR, iolS" /label="promotor_-10" upshifts 3585302 /Source="Nicolas_upshifts" /id="U3125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.788211788211788" /xcortree=1805 /SigmaFactorBS="gttttttaattttctgatttctgccattctTATTGCCTcctt cattagtaaacACATACACTTGTATGGATGGttccggatagattcatatcaatatcca c" /listShort="S1527" /listLong="iolR, iolS" /label="upshifts" S_feature 3585309..3585615 /Source="Nicolas_S_feature" /locus_tag="new_4084424_4084730" /HighExp="G180, Paraq, G150, Oxctl, H2O2, G135, Diami, LBGexp, dia5, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.788" /TUlongSig="NA" /TUlongPSig="NA" /label="S1527" promotor_-10 complement(3585455..3585474) /Source="Nicolas_upshift_promotors" /id="U3126" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=331 /SigmaFactorBS="taatataataaaaataatgaaaaaatgtagtgtttatGATTG ACTtatgggtattatgcGATTAGAATATAACCAAGAAatgaccaaaaagtaacctgtt g" /listShort="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3585473) /Source="Nicolas_upshifts" /id="U3126" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=331 /SigmaFactorBS="taatataataaaaataatgaaaaaatgtagtgtttatGATTG ACTtatgggtattatgcGATTAGAATATAACCAAGAAatgaccaaaaagtaacctgtt g" /listShort="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3585475..3585627) /Source="Nicolas_S_feature" /locus_tag="new_4084590_4084742_c" /HighExp="M40t90, M0t90, Lbtran, Diami, Heat, dia5, C30, BI, S1, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1528" promotor_-35 complement(3585489..3585496) /Source="Nicolas_upshift_promotors" /id="U3126" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=331 /SigmaFactorBS="taatataataaaaataatgaaaaaatgtagtgtttatGATTG ACTtatgggtattatgcGATTAGAATATAACCAAGAAatgaccaaaaagtaacctgtt g" /listShort="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3585575..3585582 /Source="Nicolas_upshift_promotors" /id="U3127" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig="0.99000999000999" /xcortree=329 /SigmaFactorBS="taagagaaggccgtccaaTCTTGCAAaagatatacaccgaTG TTATCATTTTTAAGCAACtattgattaacttttggtttttattatatatttatgttac g" /listShort="iolR, iolS" /listLong="S1529, yxcE, yxcD" /label="promotor_-35" promotor_-10 3585597..3585616 /Source="Nicolas_upshift_promotors" /id="U3127" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig="0.99000999000999" /xcortree=329 /SigmaFactorBS="taagagaaggccgtccaaTCTTGCAAaagatatacaccgaTG TTATCATTTTTAAGCAACtattgattaacttttggtttttattatatatttatgttac g" /listShort="iolR, iolS" /listLong="S1529, yxcE, yxcD" /label="promotor_-10" upshifts 3585617 /Source="Nicolas_upshifts" /id="U3127" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig="0.99000999000999" /xcortree=329 /SigmaFactorBS="taagagaaggccgtccaaTCTTGCAAaagatatacaccgaTG TTATCATTTTTAAGCAACtattgattaacttttggtttttattatatatttatgttac g" /listShort="iolR, iolS" /listLong="S1529, yxcE, yxcD" /label="upshifts" promotor_-10 complement(3585628..3585647) /Source="Nicolas_upshift_promotors" /id="U3128" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=332 /SigmaFactorBS="ctgaatccgcatcagtttcatataaaaaactcctTCTTGAAT ctttacgtaacataaATATATAATAAAAACCAAAAgttaatcaatagttgcttaaaaa t" /listShort="S1528" /listLong="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /label="promotor_-10" upshifts complement(3585644) /Source="Nicolas_upshifts" /id="U3128" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=332 /SigmaFactorBS="ctgaatccgcatcagtttcatataaaaaactcctTCTTGAAT ctttacgtaacataaATATATAATAAAAACCAAAAgttaatcaatagttgcttaaaaa t" /listShort="S1528" /listLong="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /label="upshifts" promotor_-35 complement(3585663..3585670) /Source="Nicolas_upshift_promotors" /id="U3128" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=332 /SigmaFactorBS="ctgaatccgcatcagtttcatataaaaaactcctTCTTGAAT ctttacgtaacataaATATATAATAAAAACCAAAAgttaatcaatagttgcttaaaaa t" /listShort="S1528" /listLong="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /label="promotor_-35" CDS 3585684..3586439 /gene="iolR" /locus_tag="BSU_39770" /old_locus_tag="BSU39770" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 11807058, 18310071, 24878601, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 11807058, 18310071, 24878601, 26735940; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the iol operon (DeoR family)" /protein_id="NP_391856.1" /db_xref="EnsemblGenomes-Gn:BSU39770" /db_xref="EnsemblGenomes-Tr:CAB16013" /db_xref="GOA:P46337" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11364" /db_xref="UniProtKB/Swiss-Prot:P46337" /translation="MKLMRIQEMEEYILSHGTVSLDELCQVFNVSKNTVRRDINKLTE KGAIEKVYGGVTSIEKTALVPFENRTIQHQDEKTKIAHYASRFIEDHDLVFIDSGTTT KSILDTLDPAKNVTILTNSLDIINAASALKNINLIIIGNNYKRKTRSFVGMDDPAMLD KYNINKAFMSATGTTLTHGLTNSDLLEYEIKKRISEKAKEVYLLADHSKFGKSTLLTY APFDRLHCIVTSQPLDDEYTQYCNEHQIGIHLA*" /label="iolR CDS" gene 3585684..3586439 /gene="iolR" /locus_tag="BSU_39770" /old_locus_tag="BSU39770" /label="iolR gene" promotor_-35 3586418..3586424 /Source="Nicolas_upshift_promotors" /id="U3129" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.841158841158841" /psig="0.994005994005994" /xcortree=2059 /SigmaFactorBS="acacgcagtactgcaatgagcatcaAATCGGCattcatctgg cctaACGTTTACAATAGTGTTGAGagtctatcatccattttattctaggaggcagatc a" /listShort="iolS, S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3586439..3586458 /Source="Nicolas_upshift_promotors" /id="U3129" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.841158841158841" /psig="0.994005994005994" /xcortree=2059 /SigmaFactorBS="acacgcagtactgcaatgagcatcaAATCGGCattcatctgg cctaACGTTTACAATAGTGTTGAGagtctatcatccattttattctaggaggcagatc a" /listShort="iolS, S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3586453 /Source="Nicolas_upshifts" /id="U3129" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.841158841158841" /psig="0.994005994005994" /xcortree=2059 /SigmaFactorBS="acacgcagtactgcaatgagcatcaAATCGGCattcatctgg cctaACGTTTACAATAGTGTTGAGagtctatcatccattttattctaggaggcagatc a" /listShort="iolS, S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="upshifts" CDS 3586493..3587425 /gene="iolS" /locus_tag="BSU_39780" /old_locus_tag="BSU39780" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9226270, 15019785, 22720735, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldo-keto reductase" /protein_id="NP_391857.1" /db_xref="EnsemblGenomes-Gn:BSU39780" /db_xref="EnsemblGenomes-Tr:CAB16014" /db_xref="GOA:P46336" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:1PYF" /db_xref="PDB:1PZ0" /db_xref="SubtiList:BG11363" /db_xref="UniProtKB/Swiss-Prot:P46336" /translation="MKKAKLGKSDLQVFPIGLGTNAVGGHNLYPNLNEETGKELVREA IRNGVTMLDTAYIYGIGRSEELIGEVLREFNREDVVIATKAAHRKQGNDFVFDNSPDF LKKSVDESLKRLNTDYIDLFYIHFPDEHTPKDEAVNALNEMKKAGKIRSIGVSNFSLE QLKEANKDGLVDVLQGEYNLLNREAEKTFFPYTKEHNISFIPYFPLVSGLLAGKYTED TTFPEGDLRNEQEHFKGERFKENIRKVNKLAPIAEKHNVDIPHIVLAWYLARPEIDIL IPGAKRADQLIDNIKTADVTLSQEDISFIDKLFA*" /label="iolS CDS" gene 3586493..3587425 /gene="iolS" /locus_tag="BSU_39780" /old_locus_tag="BSU39780" /label="iolS gene" downshifts 3587427 /Source="Nicolas_upshifts" /id="D2054" /incds=0 /nref=154 /ntot=259 /MaxReadThrough="4.521" /MaxDrop="7.17874" /score="39.70215" /energy="-17.1" /TU="U3129" /idTUdmin="U3127" /TUdmin=6 /isTUend="TRUE" /label="downshifts" promotor_-35 3587504..3587511 /Source="Nicolas_upshift_promotors" /id="U3130" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig="0.835164835164835" /xcortree=2016 /SigmaFactorBS="ataaattcctaaataactgattttgaagcaaaaCCTTACAAa atgagccataaaTCCGATAAAATAAAGGTAGTttatctcagaaagaaagtgattgaga a" /listShort="S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3587525..3587544 /Source="Nicolas_upshift_promotors" /id="U3130" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig="0.835164835164835" /xcortree=2016 /SigmaFactorBS="ataaattcctaaataactgattttgaagcaaaaCCTTACAAa atgagccataaaTCCGATAAAATAAAGGTAGTttatctcagaaagaaagtgattgaga a" /listShort="S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3587531..3587686 /Source="Nicolas_S_feature" /locus_tag="new_4086646_4086801" /HighExp="dia5, LPhT, Diami, Etha, dia15, LBGstat, M9-stat, Lbtran, T0.30H, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.835, 0.994" /TUlongSig="SigA" /TUlongPSig="0.99" /label="S1529" upshifts 3587531 /Source="Nicolas_upshifts" /id="U3130" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig="0.835164835164835" /xcortree=2016 /SigmaFactorBS="ataaattcctaaataactgattttgaagcaaaaCCTTACAAa atgagccataaaTCCGATAAAATAAAGGTAGTttatctcagaaagaaagtgattgaga a" /listShort="S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="upshifts" CDS 3587687..3588337 /gene="yxcE" /locus_tag="BSU_39790" /old_locus_tag="BSU39790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391858.1" /db_xref="EnsemblGenomes-Gn:BSU39790" /db_xref="EnsemblGenomes-Tr:CAB16015" /db_xref="GOA:P46335" /db_xref="SubtiList:BG11362" /db_xref="UniProtKB/Swiss-Prot:P46335" /translation="MKLKYVKALVAVTVALGVLLPSTISHAKSFSGRSSSSYSSRSSS SSYSGSYKSSPKSSYSSGSSSSSKKSKTSDDSSSSISLKKKPSEKASSSSSKKSSGTF SGATSKVTGKTYSGKTSKAYVGGRYVSVNHYYHAGFAPSGWFGYYSGFTMGMFMISMM HPWGYTYHPVGGPGYVSYGASPIAWIVDIIALIIILIIVIALIRAFKAPKTYRRRF*" /label="yxcE CDS" gene 3587687..3588337 /gene="yxcE" /locus_tag="BSU_39790" /old_locus_tag="BSU39790" /label="yxcE gene" CDS 3588341..3588649 /gene="yxcD" /locus_tag="BSU_39800" /old_locus_tag="BSU39800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391859.1" /db_xref="EnsemblGenomes-Gn:BSU39800" /db_xref="EnsemblGenomes-Tr:CAB16016" /db_xref="InterPro:IPR020516" /db_xref="SubtiList:BG11361" /db_xref="UniProtKB/Swiss-Prot:P46334" /translation="MRLILNEQEIVDGICVYISNEEDIYPEDVEVKELSYNKRTGFFA EATFGLHHKQLMSDDISEGIIQFLEEYHNFNPDVTVVELQFDKKKGFSALVFVNEAEE *" /label="yxcD CDS" gene 3588341..3588649 /gene="yxcD" /locus_tag="BSU_39800" /old_locus_tag="BSU39800" /label="yxcD gene" downshifts 3588651 /Source="Nicolas_upshifts" /id="D2055" /incds=0 /nref=185 /ntot=262 /MaxReadThrough="1.91541" /MaxDrop="6.4314" /score="14.1581732" /energy="-8.8" /TU="NA" /idTUdmin="U3130" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 3588793..3588799 /Source="Nicolas_upshift_promotors" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3588815..3588833 /Source="Nicolas_upshift_promotors" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3588825 /Source="Nicolas_upshifts" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="upshifts" CDS 3588887..3590272 /gene="csbC" /locus_tag="BSU_39810" /old_locus_tag="BSU39810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10376822, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite transporter" /protein_id="NP_391860.1" /db_xref="EnsemblGenomes-Gn:BSU39810" /db_xref="EnsemblGenomes-Tr:CAB16017" /db_xref="GOA:P46333" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11360" /db_xref="UniProtKB/Swiss-Prot:P46333" /translation="MKKDTRKYMIYFFGALGGLLYGYDTGVISGALLFINNDIPLTTL TEGLVVSMLLLGAIFGSALSGTCSDRWGRRKVVFVLSIIFIIGALACAFSQTIGMLIA SRVILGLAVGGSTALVPVYLSEMAPTKIRGTLGTMNNLMIVTGILLAYIVNYLFTPFE AWRWMVGLAAVPAVLLLIGIAFMPESPRWLVKRGSEEEARRIMNITHDPKDIEMELAE MKQGEAEKKETTLGVLKAKWIRPMLLIGVGLAIFQQAVGINTVIYYAPTIFTKAGLGT SASALGTMGIGILNVIMCITAMILIDRVGRKKLLIWGSVGITLSLAALSGVLLTLGLS ASTAWMTVVFLGVYIVFYQATWGPVVWVLMPELFPSKARGAATGFTTLVLSAANLIVS LVFPLMLSAMGIAWVFMVFSVICLLSFFFAFYMVPETKGKSLEEIEASLKKRFKKKKS TQNQVLNERTL*" /label="csbC CDS" gene 3588887..3590272 /gene="csbC" /locus_tag="BSU_39810" /old_locus_tag="BSU39810" /label="csbC gene" downshifts 3590258 /Source="Nicolas_upshifts" /id="D2056" /incds=0 /nref=69 /ntot=115 /MaxReadThrough="4.59405" /MaxDrop="7.32264" /score="22.9943012" /energy="-16.4" /TU="NA" /idTUdmin="U3131" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 3590303..3590853 /Source="Nicolas_S_feature" /locus_tag="new_4089418_4089968" /HighExp="Etha, C30, C90, Gly, Sw, G135, Fru, HiTm, M/G, Mal" /AntisenseName="htpG" /AntisenseCor="7.4766600377621104E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1530" CDS complement(3590314..3592194) /gene="htpG" /locus_tag="BSU_39820" /old_locus_tag="BSU39820" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9150201, 10323241, 11407116, 12511492, 22226636, 26743745, 27723736, 28363677, 28383119, 28784328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150201, 10323241, 11407116, 12511492, 22226636, 26743745, 27723736, 28363677, 28383119, 28784328; Product type f: factor" /codon_start=1 /transl_table=11 /product="class III heat-shock protein (ATP-dependent molecular chaperone HSP90)" /protein_id="NP_391861.1" /db_xref="EnsemblGenomes-Gn:BSU39820" /db_xref="EnsemblGenomes-Tr:CAB16018" /db_xref="GOA:P46208" /db_xref="InterPro:IPR001404" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR019805" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020575" /db_xref="InterPro:IPR036890" /db_xref="InterPro:IPR037196" /db_xref="SubtiList:BG11359" /db_xref="UniProtKB/Swiss-Prot:P46208" /translation="MAKKEFKAESKRLLDMMINSIYTQKEIFLRELISNSSDAIDKIY YKALTDDALTFDKDSYYIKVAADKDARTLTISDTGIGMTKDELEQHLGTIAKSGSLAF KKENELKDGHDIIGQFGVGFYAAFMVADVVTVISKALGSEEAYKWESAGADGYTIEPC EKDSVGTDIILKIKENTEDDSYDEFLEEYRLKAIIKKYSDFIRYPIKMDTTINKPKEG SENEFEEVQEEQTVNSMVPIWRKNKSELTDEDYEKFYAEKHYGFDKPLTHVHISVDGA VRYNAILFVPENMPFDYYSKEYEKGLELYSNGVLIMNKCADLLPDHFSFVKGMVDSED LSLNISREMLQHDRQLKLIAKNISKKIKSELQSLLKKDREKYETFYKSFGRQLKFGVY NDFGANKDQLKDLLLFYSSKEKKLVSLDEYVSRMPEEQKFIYYATGDSYDRIEKLPQT EMVADKGYEILYFTEDIDEFAIKMLASYQEKEFKSVSSGDLGIDTDEDQKQSEEEESK YKDLFEEMKNILSDKVKNVRISKRLKSHPVCLAADGEVTIEMEKILNAMPDSQNVKAE KVLEINPNHEVFQTLQDAFEQDKEKLSLYTNLLYNQALLIEGLPIQDPVEFTNNICKV MV*" /label="htpG CDS" gene complement(3590314..3592194) /gene="htpG" /locus_tag="BSU_39820" /old_locus_tag="BSU39820" /label="htpG gene" downshifts complement(3590320) /Source="Nicolas_upshifts" /id="D2057" /incds=0 /nref=169 /ntot=288 /MaxReadThrough="0.81611" /MaxDrop="6.49379" /score="34.0973015" /energy="-16.4" /TU="NA" /idTUdmin="U3132" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" S_feature complement(3592195..3592292) /Source="Nicolas_S_feature" /locus_tag="new_4091310_4091407_c" /HighExp="Lbtran, S1, LBGtran, C90, M40t45, M9-tran, GM 150, dia0, T-2.40H, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="SigA" /TUlongPSig="0.995" /label="S1531" promotor_-10 complement(3592283..3592302) /Source="Nicolas_upshift_promotors" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3592292) /Source="Nicolas_upshifts" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3592317..3592324) /Source="Nicolas_upshift_promotors" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3592362..3592613) /gene="yxcA" /locus_tag="BSU_39830" /old_locus_tag="BSU39830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391862.1" /db_xref="EnsemblGenomes-Gn:BSU39830" /db_xref="EnsemblGenomes-Tr:CAB16019" /db_xref="GOA:P46332" /db_xref="SubtiList:BG11358" /db_xref="UniProtKB/Swiss-Prot:P46332" /translation="MKVQHKKELKFYCIVTIPSAFVVLTVISFLLQEITFPVTASAFL NASWHNLLFLIPFGLFFYPVHIWMKREFGRWNDTEKKRG*" /label="yxcA CDS" gene complement(3592362..3592613) /gene="yxcA" /locus_tag="BSU_39830" /old_locus_tag="BSU39830" /label="yxcA gene" downshifts complement(3592380) /Source="Nicolas_upshifts" /id="D2058" /incds=0 /nref=11 /ntot=62 /MaxReadThrough="3.50049" /MaxDrop="5.56962" /score="-3.89567108" /energy="-6.7" /TU="U3133" /idTUdmin="U3133" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" misc_feature complement(3592635..3592654) /Source="Nicolas_upshift_promotors" /id="U3133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.995004995004995" /xcortree=2181 /SigmaFactorBS="gtcttcccgctatgtgcagtgataaacatgcgagaaaagaaa ggccagcaTATGTTAAGATGAATTAGAAattgttgggaggtttgtatgtttgaaggta c" /listShort="yxcA" /listLong="S1531, htpG" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3592644) /Source="Nicolas_upshifts" /id="U3133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.995004995004995" /xcortree=2181 /SigmaFactorBS="gtcttcccgctatgtgcagtgataaacatgcgagaaaagaaa ggccagcaTATGTTAAGATGAATTAGAAattgttgggaggtttgtatgtttgaaggta c" /listShort="yxcA" /listLong="S1531, htpG" /label="upshifts" promotor_-35 3592677..3592683 /Source="Nicolas_upshift_promotors" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3592697..3592715 /Source="Nicolas_upshift_promotors" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3592698 /Source="Nicolas_upshifts" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="upshifts" CDS 3592730..3593551 /gene="yxbG" /locus_tag="BSU_39840" /old_locus_tag="BSU39840" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10746760; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391863.2" /db_xref="EnsemblGenomes-Gn:BSU39840" /db_xref="EnsemblGenomes-Tr:CAB16020" /db_xref="GOA:P46331" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11357" /db_xref="UniProtKB/Swiss-Prot:P46331" /translation="MGRLENKTAVITGAATGIGQATAEVFANEGARVIIGDINKDQME ETVDAIRKNGGQAESFHLDVSDENSVKAFADQIKDACGTIDILFNNAGVDQEGGKVHE YPVDLFDRIIAVDLRGTFLCSKYLIPLMLENGGSIINTSSMSGRAADLDRSGYNAAKG GITNLTKAMAIDYARNGIRVNSISPGTIETPLIDKLAGTKEQEMGEQFREANKWITPL GRLGQPKEMATVALFLASDDSSYVTGEDITADGGIMAYTWPGKMLIEEKWKEETK*" /label="yxbG CDS" gene 3592730..3593551 /gene="yxbG" /locus_tag="BSU_39840" /old_locus_tag="BSU39840" /label="yxbG gene" downshifts 3593535 /Source="Nicolas_upshifts" /id="D2059" /incds=0 /nref=22 /ntot=67 /MaxReadThrough="2.87575" /MaxDrop="5.67438" /score="22.9485028" /energy="-10.5" /TU="U3134" /idTUdmin="U3134" /TUdmin="-221" /isTUend="FALSE" /label="downshifts" CDS complement(3593580..3594722) /gene="yxbF" /locus_tag="BSU_39850" /old_locus_tag="BSU39850" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11160890; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391864.1" /db_xref="EnsemblGenomes-Gn:BSU39850" /db_xref="EnsemblGenomes-Tr:CAB16021" /db_xref="GOA:P46330" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG11356" /db_xref="UniProtKB/Swiss-Prot:P46330" /translation="MPESAEAQVKEALLALLKDRDIQHITMKEIAEKAKVSRGSLYLY YEDKFSIIEDVIEDMKEGLGKALFDAFSHMDTLHLNKKRQTVHPTLSFVHEHRSFFSV MMNRGHFHRFFKDVFQQDVLLAPIHVNLTPIERDIYGHYRALYTYAIILYWLNEDAAA SPEAISQKVWELVSQKRFYWLFGKAVPGEREKEKQIDRRVVRTREALQKAFLDVLAEK QDYAGITISDITRKSNIRRATFYDHYANKEELLQTMIQRSCAEIIDHLTIASSPNEFS LKEAEKALAILLSALSNMPIVHFLNREWGVPHVIPDMFKALESFYLHQQTDIHAEKKL YAHYVSAMIIGLLLYRLDEGKAHPPEVLAREFLQFLDVKKYKVVLL*" /label="yxbF CDS" gene complement(3593580..3594722) /gene="yxbF" /locus_tag="BSU_39850" /old_locus_tag="BSU39850" /label="yxbF gene" downshifts complement(3593590) /Source="Nicolas_upshifts" /id="D2060" /incds=0 /nref=10 /ntot=163 /MaxReadThrough="1.63217" /MaxDrop="3.79969" /score="-0.564494299" /energy="-10.5" /TU="NA" /idTUdmin="U3135" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3594723..3594822) /Source="Nicolas_S_feature" /locus_tag="new_4093838_4093937_c" /HighExp="H2O2, Diami, dia15, Paraq, G180, G135, G150, dia5, Oxctl, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1532" promotor_-10 complement(3594810..3594829) /Source="Nicolas_upshift_promotors" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3594821) /Source="Nicolas_upshifts" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3594843..3594850) /Source="Nicolas_upshift_promotors" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3594865..3596202 /gene="aldX" /locus_tag="BSU_39860" /old_locus_tag="BSU39860" /EC_number="1.2.1.3" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391865.2" /db_xref="EnsemblGenomes-Gn:BSU39860" /db_xref="EnsemblGenomes-Tr:CAB16022" /db_xref="GOA:P46329" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11355" /db_xref="UniProtKB/Swiss-Prot:P46329" /translation="MEQQVKDDIQRVFQLQKKQQKALRASTAEQRREKLQRFLDSVIA HEEEIIEAIRKDVRKPYHEVKKAEIEGTKKAIRDNMNNLEQWMAPKEVGSSLSPDANG ILMYEPKGVTLILGPWNYPFMLTMAPLAASLAAGNSAIVKLSDFTMNTSNIAAKVIRD AFDEKEVAIFEGEVEVATELLDQPFDHIFFTGSTNVGKIVMTAAAKHLASVTLELGGK SPTIIDSEYDLMDAAKKIAVGKFVNAGQTCIAPDYLFIKKDVQDRFAGILQTVVNAGF MEDDHTPDRSKFTQIVNDRNFNRVKDLFDDAIERGAEVVFGGVFDASDRTISPTVLKN VTPDMKIMQEEIFASILPMMNYEDIDEVIDYVNDRDKPLALYVFSKNQDLIDNVLQHT TSGNAAINDVVVHFSDVNLPFGGVNTSGIGSYHGVYGFKEFSHEKGVFIQAAE*" /label="aldX CDS" gene 3594865..3596202 /gene="aldX" /locus_tag="BSU_39860" /old_locus_tag="BSU39860" /label="aldX gene" S_feature complement(3595607..3596207) /Source="Nicolas_S_feature" /locus_tag="new_4094722_4095322_c" /HighExp="T1.30H, T2.30H, T2.0H, T1.0H, T-2.40H, T3.0H, T3.30H, T0.0H, T-0.40H, T-3.40H" /AntisenseName="aldX" /AntisenseCor="-0.39894728806999702" /AntisenseRegPval="-11" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1533" CDS complement(3596241..3596720) /gene="yxbD" /locus_tag="BSU_39870" /old_locus_tag="BSU39870" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_391866.2" /db_xref="EnsemblGenomes-Gn:BSU39870" /db_xref="EnsemblGenomes-Tr:CAB16023" /db_xref="GOA:P46328" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11354" /db_xref="UniProtKB/Swiss-Prot:P46328" /translation="MNIIPTCQVPKDLVSAFFQKHWGSPQMVISSGIYNCDELDGYGM LNDDNQIVGLITYIFEEDACEIISLDSVIENKGIGTALLEKAEEACRERNIKQIKLIT TNDNIHALAFYQKRGYRLDRLFVNAVETARKMKPEIPLLADNKIPIRDELLLVKELQ* " /label="yxbD CDS" gene complement(3596241..3596720) /gene="yxbD" /locus_tag="BSU_39870" /old_locus_tag="BSU39870" /label="yxbD gene" downshifts complement(3596252) /Source="Nicolas_upshifts" /id="D2061" /incds=0 /nref=1 /ntot=39 /MaxReadThrough="3.82941" /MaxDrop="2.52984" /score="-7.41869067" /energy="-10.9" /TU="U3136" /idTUdmin="U3136" /TUdmin="-616" /isTUend="FALSE" /label="downshifts" CDS complement(3596800..3597792) /gene="yxbC" /locus_tag="BSU_39880" /old_locus_tag="BSU39880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391867.1" /db_xref="EnsemblGenomes-Gn:BSU39880" /db_xref="EnsemblGenomes-Tr:CAB16024" /db_xref="GOA:P46327" /db_xref="InterPro:IPR003347" /db_xref="PDB:1VRB" /db_xref="SubtiList:BG11353" /db_xref="UniProtKB/Swiss-Prot:P46327" /translation="MSAVTESVLESIISPVTMSEFLEEYWPVKPLVARGEVERFTSIP GFEKVRTLENVLAIYNNPVMVVGDAVIEESEGITDRFLVSPAEALEWYEKGAALEFDF TDLFIPQVRRWIEKLKAELRLPAGTSSKAIVYAAKNGGGFKAHFDAYTNLIFQIQGEK TWKLAKNENVSNPMQHYDLSEAPYYPDDLQSYWKGDPPKEDLPDAEIVNLTPGTMLYL PRGLWHSTKSDQATLALNITFGQPAWLDLMLAALRKKLISDNRFRELAVNHQSLHESS KSELNGYLESLIQTLSENAETLTPEQIFQSQDSDFDPYQSTQLVFRQLLTSYKF*" /label="yxbC CDS" gene complement(3596800..3597792) /gene="yxbC" /locus_tag="BSU_39880" /old_locus_tag="BSU39880" /label="yxbC gene" downshifts complement(3596824) /Source="Nicolas_upshifts" /id="D2062" /incds=0 /nref=5 /ntot=98 /MaxReadThrough="5.86537" /MaxDrop="5.28716" /score="-7.41869067" /energy="-10.9" /TU="U3136" /idTUdmin="U3136" /TUdmin="-1188" /isTUend="FALSE" /label="downshifts" downshifts 3597782 /Source="Nicolas_upshifts" /id="D2063" /incds=0 /nref=2 /ntot=56 /MaxReadThrough="1.15059" /MaxDrop="3.74519" /score="9.93493822" /energy="-12.4" /TU="NA" /idTUdmin="U3134" /TUdmin=4026 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3597815..3597834) /Source="Nicolas_upshift_promotors" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3597833) /Source="Nicolas_upshifts" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3597849..3597856) /Source="Nicolas_upshift_promotors" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3597855..3597862 /Source="Nicolas_upshift_promotors" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3597876..3598300 /Source="Nicolas_S_feature" /locus_tag="new_4096991_4097415" /HighExp="T2.0H, T5.0H, M9-stat, T3.0H, T1.30H, T1.0H, T3.30H, T2.30H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.998942" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1534" upshifts 3597876 /Source="Nicolas_upshifts" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3597877..3597896 /Source="Nicolas_upshift_promotors" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 3597882..3598294 /gene="srlX" /locus_tag="BSU_misc_RNA_86" /product="putative small RNA or mRNA leader sequence" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="srlX RNA" gene 3597882..3598294 /gene="srlX" /locus_tag="BSU_misc_RNA_86" /label="srlX gene" upshifts complement(3597902) /Source="Nicolas_upshifts" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3597912..3597926) /Source="Nicolas_upshift_promotors" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3597934..3597938) /Source="Nicolas_upshift_promotors" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3598266 /Source="Nicolas_upshifts" /id="D2064" /incds=0 /nref=2 /ntot=9 /MaxReadThrough="8.39077" /MaxDrop="5.02548" /score="9.93493822" /energy="-12.4" /TU="U3137" /idTUdmin="U3134" /TUdmin=4510 /isTUend="FALSE" /label="downshifts" CDS 3598301..3599035 /gene="yxbB" /locus_tag="BSU_39890" /old_locus_tag="BSU39890" /EC_number="2.1.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15941984, 20185509; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative S-adenosylmethionine-dependent methyltransferase" /protein_id="NP_391868.1" /db_xref="EnsemblGenomes-Gn:BSU39890" /db_xref="EnsemblGenomes-Tr:CAB16025" /db_xref="GOA:P46326" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11352" /db_xref="UniProtKB/Swiss-Prot:P46326" /translation="MITAEECRTYKEFVDLYQSYLYPLLGARLSRMYSPKNKVIIDMG TGPGYLSIQLAKRTNAHVHAVDINPAMHEIAQEEAKKSGVSSLISFDLEDVHHLSYAD QYADFIVSYSCLHHWEDVVKGLKECYRVLAPGGKIVILDTFNPQGSHLEIMRKQIKEP EYFRFVREAFEESYSFEDIHQFVQDAGIPNYSLETFHFLPEDFIESLDELEDAPLWEQ NDQSTDHEIESVTWMLTIEKEKEGAL*" /label="yxbB CDS" gene 3598301..3599035 /gene="yxbB" /locus_tag="BSU_39890" /old_locus_tag="BSU39890" /label="yxbB gene" CDS 3599035..3599304 /gene="yxbA" /locus_tag="BSU_39900" /old_locus_tag="BSU39900" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17083466" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391869.1" /db_xref="EnsemblGenomes-Gn:BSU39900" /db_xref="EnsemblGenomes-Tr:CAB16026" /db_xref="InterPro:IPR008792" /db_xref="SubtiList:BG11351" /db_xref="UniProtKB/Swiss-Prot:P46325" /translation="MINESTVLSKNPEMPSRKYLKSIIIEPGITLNEMASDIYNHIDG KVSIHDICSKIVNEYDVDYQTCLEDCMELFELLIDHEAIKVKQGA*" /label="yxbA CDS" gene 3599035..3599304 /gene="yxbA" /locus_tag="BSU_39900" /old_locus_tag="BSU39900" /label="yxbA gene" CDS 3599308..3599790 /gene="yxnB" /locus_tag="BSU_39910" /old_locus_tag="BSU39910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20185509" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391870.1" /db_xref="EnsemblGenomes-Gn:BSU39910" /db_xref="EnsemblGenomes-Tr:CAB16027" /db_xref="SubtiList:BG14166" /db_xref="UniProtKB/Swiss-Prot:O34704" /translation="MEKQKVLALPDDVHELSTHRSKSIVNYIITLLAFAKKQGLTHQD IVSWIHEQYEERGYYDEWRHINSQQPVGSFVELFIKGRRLLYDKIELFETEDKYVVNT HTWYEKEPSEAFFYFEIDPEEFSAYASILAIENAKRLGIKIDIVKETDVETAYIYKHQ *" /label="yxnB CDS" gene 3599308..3599790 /gene="yxnB" /locus_tag="BSU_39910" /old_locus_tag="BSU39910" /label="yxnB gene" CDS 3599811..3602054 /gene="asnH" /locus_tag="BSU_39920" /old_locus_tag="BSU39920" /EC_number="6.3.5.4" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 17083466, 20185509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 17083466, 20185509; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparagine synthetase (glutamine-hydrolyzing)" /protein_id="NP_391871.2" /db_xref="EnsemblGenomes-Gn:BSU39920" /db_xref="EnsemblGenomes-Tr:CAB16028" /db_xref="GOA:P42113" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG11116" /db_xref="UniProtKB/Swiss-Prot:P42113" /translation="MCGLAGIINLAAPRSQECTFHILKGMADAISYRGPDDEQYHIDS KVGFAFRRLSILDLVNGQQPFLNEDGSIVVMVNGEIYNYKELKASLHNHMFKTTSDCE VIVHLYEEKGIGFVDDIIGMFSIAIWDKNKNKVFLVRDRFGIKPLFYTELKHELIFAS EIKSLFSHPHCPRQFNWKEALSDIWLSGEAASNHKETTSFFVNIQNLDAGHYLEINLT TNERKTASYWSLQDILLRQGYRENLHPDDLIEGYRELLADSVHRCLQSDVEVGLFLSG GIDSAAVAHFAAEKQDLHTFTVLSQSTFTNEDAKYAHWLAKDLHLPNHQVLYQLGNDE LLQPESYKHLLWICETPFCGPEQLYKFHLHKYAKAIRPNLKVMLTGQGSDEFNGGYST TLSPAENPSWEGFIESVNTMEMNRLHRLQGNIFRVWEEHFGLSPINLSYLKSNDSSQA DPWQSYVLTKYRDLQMYNCWHEDRIAAANHIENRVPFLDHRLVEWVCGIPDGLRKDLL WDKSVLRKSLTNELHTSYTHRPKVPFFYGKDVRYTHKMMFHLLKKNNYQLIEEAFSHS DASSIIQVEHIHAIMTYLEDDPEFTNFEFLLRLVNMGLLSKMTKETPSVQLDITSHLE SITIKDWHSQEGDIASRLNISANKCEGQDILALNPGVTLLRPESDSEHCIYIAEEGFI QFIVSEEDVGAWLHILCDINGKDTLHTILDRHGVSLEEVAKYIQEAIEHNIILIKQKN LPEGAYR*" /label="asnH CDS" gene 3599811..3602054 /gene="asnH" /locus_tag="BSU_39920" /old_locus_tag="BSU39920" /label="asnH gene" CDS 3602051..3603250 /gene="yxaM" /locus_tag="BSU_39930" /old_locus_tag="BSU39930" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15101989, 15849754, 16850406, 20185509; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391872.2" /db_xref="EnsemblGenomes-Gn:BSU39930" /db_xref="EnsemblGenomes-Tr:CAB16029" /db_xref="GOA:P42112" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11115" /db_xref="UniProtKB/Swiss-Prot:P42112" /translation="MSIFYSFSALRGLAMGIFSPIWILYLISKDYDFLQIGLMGAVLE IAKLIFEVPSGVFADRYGIKISIASSFFFSILTWAFFPFIDSAAICILAMIIWALSDS LISGSFETWMSRVAGEDRFGKEMMKNTQLLITFLIIGSIASGYLYSLNIYFPFLLVMV IYLLLFIWMSVFIKVPSVSETNHGDQNQHDSIKIIKESLKIIFNKKRVLLIVIAGFFT ATAYDTISRYWQPFLSDLGFSEKSLGYIFALGGFTALVLLTLTIRFEKKIEKNPYLAL TSLDSMGMVMTFLLSRAFRPLGIPCTAFLLAIEDIHHPIVTSYLNKFFPDSYKNTLFS LNSGVGAIGEILSGVIFGIISAAFGLSAMFVVVAVFLLIPIILYTIVPKIKDNDMKVQ IEKSQQV*" /label="yxaM CDS" gene 3602051..3603250 /gene="yxaM" /locus_tag="BSU_39930" /old_locus_tag="BSU39930" /label="yxaM gene" promotor_-10 complement(3603006..3603024) /Source="Nicolas_upshift_promotors" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3603028) /Source="Nicolas_upshifts" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3603039..3603045) /Source="Nicolas_upshift_promotors" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3603241 /Source="Nicolas_upshifts" /id="D2065" /incds=0 /nref=71 /ntot=174 /MaxReadThrough="3.22879" /MaxDrop="5.42242" /score="-6.94914943" /energy="-8.5" /TU="U3137" /idTUdmin="U3137" /TUdmin="-85" /isTUend="FALSE" /label="downshifts" downshifts complement(3603314) /Source="Nicolas_upshifts" /id="D2066" /incds=0 /nref=156 /ntot=227 /MaxReadThrough="3.53794" /MaxDrop="6.77896" /score="7.32872401" /energy="-16.9" /TU="U3140" /idTUdmin="U3141" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3603314..3604546) /gene="yxaL" /locus_tag="BSU_39940" /old_locus_tag="BSU39940" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12073041, 15743949, 17060472, 18165306, 22720735, 26060272; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="membrane associated protein kinase with beta-propeller domain" /protein_id="NP_391873.2" /db_xref="EnsemblGenomes-Gn:BSU39940" /db_xref="EnsemblGenomes-Tr:CAB16030" /db_xref="GOA:P42111" /db_xref="InterPro:IPR002372" /db_xref="InterPro:IPR011047" /db_xref="InterPro:IPR018391" /db_xref="SubtiList:BG11114" /db_xref="UniProtKB/Swiss-Prot:P42111" /translation="MVKSFRMKALIAGAAVAAAVSAGAVSDVPAAKVLQPTAAYAAET VFSQNNGASGFLPGRYDVQAMAPAMFNWSRESRFAGNTDGTLKWQNDIRTTPQNGAGA VIDGDGTVYLHSRDGEMKAFNPDGSVKWVTGNLGKTYTQSPVLGTNGVIYLASYDKKI YFIDKETGEILTTVPLSGGPSSETVIGSDGTLYFSTLDNYVHAIKPTSKSTWTERWKL KTNGVVSSVPVLAKNGTVYVGTYNYVFYAINSGTGQVKWSRTTSNAFKGYPVIDKDGN IYAGNQDGQLYAYTSTGSLKWTFPLNGFSSSSPAIDHNGNIYIGSGSGELFSISKNGD MNWSFYTDGPVRTAPLIDAKGTVYFGSDDMKVYAADANGNELWSYQTDSNVVSSPQLA EDGTLYIGSYTKLMAFGK*" /label="yxaL CDS" gene complement(3603314..3604546) /gene="yxaL" /locus_tag="BSU_39940" /old_locus_tag="BSU39940" /label="yxaL gene" promotor_-10 complement(3604578..3604597) /Source="Nicolas_upshift_promotors" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3604590) /Source="Nicolas_upshifts" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3604611..3604616) /Source="Nicolas_upshift_promotors" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3604647..3605072) /gene="yxaJ" /locus_tag="BSU_39950" /old_locus_tag="BSU39950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15743949, 15849754, 16850406, 27902860; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391875.2" /db_xref="EnsemblGenomes-Gn:BSU39950" /db_xref="EnsemblGenomes-Tr:CAB16032" /db_xref="GOA:P42109" /db_xref="InterPro:IPR020204" /db_xref="SubtiList:BG11112" /db_xref="UniProtKB/Swiss-Prot:P42109" /translation="MSKKNSVAIMTTISAFLFCAVIVAASLSPLAGTGAAANQFNSAG MWSAVGMILVLYFIPFLVYMLGVDAMRYVMAVLCGFGLLIHLSSAGFILMFSFFSDHL LSEVIFVLGVSLAAAAVNVIWFVAAFRSGAEKTSVNTLT*" /label="yxaJ CDS" gene complement(3604647..3605072) /gene="yxaJ" /locus_tag="BSU_39950" /old_locus_tag="BSU39950" /label="yxaJ gene" promotor_-10 complement(3605100..3605119) /Source="Nicolas_upshift_promotors" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3605114) /Source="Nicolas_upshifts" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3605132..3605138) /Source="Nicolas_upshift_promotors" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3605264..3605271 /Source="Nicolas_upshift_promotors" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3605281 /Source="Nicolas_upshifts" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3605286..3605305 /Source="Nicolas_upshift_promotors" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3605329..3605784 /gene="yxaI" /locus_tag="BSU_39960" /old_locus_tag="BSU39960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391876.1" /db_xref="EnsemblGenomes-Gn:BSU39960" /db_xref="EnsemblGenomes-Tr:CAB16033" /db_xref="GOA:P42108" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG11111" /db_xref="UniProtKB/Swiss-Prot:P42108" /translation="MEKPAGFWIRFLAYFIDGIIVSVPSYIILFIINSVFVAGAVATN PYMTEEEYLVKYMTLAFLPTMLIMIVISVLYYGLLTASKMQGTLGKKILGLKVVNEQG ERVSVGQGIGRYFAYILSGIIFYIGFIMIAFGEKKGLHDIICKTRVVYK*" /label="yxaI CDS" gene 3605329..3605784 /gene="yxaI" /locus_tag="BSU_39960" /old_locus_tag="BSU39960" /label="yxaI gene" downshifts 3605722 /Source="Nicolas_upshifts" /id="D2067" /incds=1 /nref=58 /ntot=234 /MaxReadThrough="3.24719" /MaxDrop="5.4441" /score="18.1083522" /energy="-13.4" /TU="U3142" /idTUdmin="U3142" /TUdmin="-637" /isTUend="FALSE" /label="downshifts" S_feature 3605785..3606398 /Source="Nicolas_S_feature" /locus_tag="new_4104900_4105513" /HighExp="LPh, HPh, MG 60, BMM, MG t5, G180, MG 45, G150, MG-0.2, MG 10" /AntisenseName="yxaH" /AntisenseCor="0.37646026982403002" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1535" CDS complement(3605814..3607022) /gene="yxaH" /locus_tag="BSU_39970" /old_locus_tag="BSU39970" /experiment="publication(s) with functional evidences, PMID:15317768, 15849754, 16850406, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317768, 15849754, 16850406, 21737930; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="integral inner membrane protein involved in response to flavonoids" /protein_id="NP_391877.2" /db_xref="EnsemblGenomes-Gn:BSU39970" /db_xref="EnsemblGenomes-Tr:CAB16034" /db_xref="GOA:P42107" /db_xref="InterPro:IPR007349" /db_xref="SubtiList:BG11110" /db_xref="UniProtKB/Swiss-Prot:P42107" /translation="MSSLQPTLTNERIGVLDVLRGMAIFGILFVNLAHFSYPDMYLSM LGKENFFMDKWSEADFAAADILKFFIQTKCILLFSFLFGFGMVVMMERAENKGKRFVP LYVRRLMALLLFGTIHAFLIWDGDILTEYALLGFVLLLFRKAKPKTLLIWAVSLYLLF SIPFMLTSFDQSNGQEWVQAVTQQAKQAIHVYGSGSLKDIAEQRIHDRLVYMSSNGML TYNPLNYFFASIPYFSMFLLGAAAAKSRYLHEPEKHRKGLKRLWMAGLVIGIGAQVLY SVTDKEICLLIGAPFLMFFYVTTVVYLYHKTRVRTVLQSFSAVGRMAFTNYLMQSIVC TWIFYHYGLGLYGKVYPAAGVLITIAVCAVQMVFSHLWLRVFRMGPFEWLWRSATYLS WQPIAKKTKV*" /label="yxaH CDS" gene complement(3605814..3607022) /gene="yxaH" /locus_tag="BSU_39970" /old_locus_tag="BSU39970" /label="yxaH gene" downshifts complement(3605841) /Source="Nicolas_upshifts" /id="D2068" /incds=0 /nref=14 /ntot=66 /MaxReadThrough="0.30987" /MaxDrop="3.782" /score="34.1593124" /energy="-16.2" /TU="NA" /idTUdmin="U3143" /TUdmin=286 /isTUend="FALSE" /label="downshifts" S_feature complement(3607023..3607129) /Source="Nicolas_S_feature" /locus_tag="new_4106138_4106244_c" /HighExp="T-5.40H, T-4.40H, SMMPr, T-2.40H, T-3.40H, T-1.40H, Sw, T0.0H, Pyr, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1536" CDS complement(3607130..3608143) /gene="qdoI" /locus_tag="BSU_39980" /old_locus_tag="BSU39980" /EC_number="1.13.11.24" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14697267, 15317768, 15628860, 17483215, 14741339, 15039076, 20460727, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14697267, 15317768, 15628860, 17483215, 14741339, 15039076, 20460727, 21737930; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="quercetin dioxygenase" /protein_id="NP_391878.2" /db_xref="EnsemblGenomes-Gn:BSU39980" /db_xref="EnsemblGenomes-Tr:CAB16035" /db_xref="GOA:P42106" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="PDB:1Y3T" /db_xref="PDB:2H0V" /db_xref="SubtiList:BG11109" /db_xref="UniProtKB/Swiss-Prot:P42106" /translation="MKTLCTHSLPKEKMPYLLRSGEGERYLFGRQVATVMANGRSTGD LFEIVLLSGGKGDAFPLHVHKDTHEGILVLDGKLELTLDGERYLLISGDYANIPAGTP HSYRMQSHRTRLVSYTMKGNVAHLYSVIGNPYDHAEHPPYASEEVSNERFAEAAAVAD IVFLDEAKPACSAKLAELTELPDGAVPYVLESGEGDRLLTGDQLHRIVAAQKNTDGQF IVVSSEGPKGDRIVDHYHEYHTETFYCLEGQMTMWTDGQEIQLNPGDFLHVPANTVHS YRLDSHYTKMVGVLVPGLFEPFFRTLGDPYEGHIFPCEPQALRFDRILQNIEALDLKV MKP*" /label="qdoI CDS" gene complement(3607130..3608143) /gene="qdoI" /locus_tag="BSU_39980" /old_locus_tag="BSU39980" /label="qdoI gene" S_feature complement(3608144..3608217) /Source="Nicolas_S_feature" /locus_tag="new_4107259_4107332_c" /HighExp="T-3.40H, T-5.40H, T-1.40H, T-2.40H, T-4.40H, T-0.40H, T0.0H, Pyr, SMMPr, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1537" promotor_-10 complement(3608202..3608221) /Source="Nicolas_upshift_promotors" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3608217) /Source="Nicolas_upshifts" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3608234..3608241) /Source="Nicolas_upshift_promotors" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3608237..3608812) /gene="qdoR" /locus_tag="BSU_39990" /old_locus_tag="BSU39990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17483215, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17483215, 21737930; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of qdoI" /protein_id="NP_391879.2" /db_xref="EnsemblGenomes-Gn:BSU39990" /db_xref="EnsemblGenomes-Tr:CAB16036" /db_xref="GOA:P42105" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:1SGM" /db_xref="SubtiList:BG11108" /db_xref="UniProtKB/Swiss-Prot:P42105" /translation="MTSRGDSREKILHTASRLFQLQGYHATGLNQIVKESGAPKGSLY HFFPNGKEELAIEAVTYTGKIVEHLIQQSMDESSDPVEAIQLFIKKTASQFDNTESIK GIPVGLLASETALISEPLRTVCMKVFKSWEAVFARKLMENGFAEEEANQLGTLINSMI EGGIMLSLTNKDKTPLLLIAEQIPVLVRKKG*" /label="qdoR CDS" gene complement(3608237..3608812) /gene="qdoR" /locus_tag="BSU_39990" /old_locus_tag="BSU39990" /label="qdoR gene" downshifts complement(3608261) /Source="Nicolas_upshifts" /id="D2069" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="1.66581" /MaxDrop="2.62803" /score="-2.51956315" /energy="-8.8" /TU="NA" /idTUdmin="U3144" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3608841..3608860) /Source="Nicolas_upshift_promotors" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3608855) /Source="Nicolas_upshifts" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3608875..3608882) /Source="Nicolas_upshift_promotors" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3608883..3608889 /Source="Nicolas_upshift_promotors" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3608904..3608922 /Source="Nicolas_upshift_promotors" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3608911 /Source="Nicolas_upshifts" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="upshifts" CDS 3608943..3610013 /gene="yxnA" /locus_tag="BSU_40000" /old_locus_tag="BSU40000" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391880.2" /db_xref="EnsemblGenomes-Gn:BSU40000" /db_xref="EnsemblGenomes-Tr:CAB16037" /db_xref="GOA:O32291" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14165" /db_xref="UniProtKB/Swiss-Prot:O32291" /translation="MTIDHSVTNTEQLEQQNPAIKTKLKLKKLKDQVIVITGASSGIG LVTARMAAEKGAKVVAAARNEEALKELTDELKEKGHDAIWVKADVGKEEDVNRIAETA ISTFGRFDTWVNNAAVSTFGHAMDVTVEDMKRMFDTNFWGPVYGTRAAVKHYTGRGVP GALINVGSLFGDRGTVIQSTYASAKFALHGWTESIRMELEKEQAPVSVTLIHPGRIDT PYNEHAHSYLDKQPAHYRSMIYPPEAVAEAILFAAEHPKRDMYIGSQAKAIAMLGALF PRLTDRLMEKIMYHSQHAERPSNPREESALYDAGCGMHDRGTNKGWMRSRSYYTKATK RPIVSAAVVAGLVAWAAAKRCR*" /label="yxnA CDS" gene 3608943..3610013 /gene="yxnA" /locus_tag="BSU_40000" /old_locus_tag="BSU40000" /label="yxnA gene" downshifts 3610011 /Source="Nicolas_upshifts" /id="D2070" /incds=0 /nref=7 /ntot=44 /MaxReadThrough="2.68466" /MaxDrop="3.96227" /score="-3.48213422" /energy="-11.2" /TU="NA" /idTUdmin="U3145" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3610070..3610501) /gene="yxaD" /locus_tag="BSU_40010" /old_locus_tag="BSU40010" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391881.1" /db_xref="EnsemblGenomes-Gn:BSU40010" /db_xref="EnsemblGenomes-Tr:CAB16038" /db_xref="GOA:P42103" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11106" /db_xref="UniProtKB/Swiss-Prot:P42103" /translation="MQNQNPVELIEYELTTFIRRAVYLDQSEKRTGNLERSSYLLLRQ LDEFGPARVKELAESFKLDISTLSRQAAALEAKELIYRFSDPSDGRVSLFTITKLGKQ LLKADQQKRLERYEQMLKEWSTQEKEMFGELLQRMNKAFID*" /label="yxaD CDS" gene complement(3610070..3610501) /gene="yxaD" /locus_tag="BSU_40010" /old_locus_tag="BSU40010" /label="yxaD gene" promotor_-35 3610531..3610538 /Source="Nicolas_upshift_promotors" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3610552..3610571 /Source="Nicolas_upshift_promotors" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3610561..3610727 /Source="Nicolas_S_feature" /locus_tag="new_4109676_4109842" /HighExp="LBGstat, Cold, Heat, Salt, Etha, H2O2, G180, LBGtran, GM 150, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1538" upshifts 3610561 /Source="Nicolas_upshifts" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3610613..3610632) /Source="Nicolas_upshift_promotors" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3610633) /Source="Nicolas_upshifts" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3610647..3610654) /Source="Nicolas_upshift_promotors" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3610728..3611132 /gene="yxzK" /locus_tag="BSU_40021" /old_locus_tag="BSU40021" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein involved in export murein hydrolases" /protein_id="YP_003097798.1" /db_xref="EnsemblGenomes-Gn:BSU40021" /db_xref="EnsemblGenomes-Tr:CAX52713" /db_xref="GOA:C0H3T7" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR036640" /db_xref="UniProtKB/Swiss-Prot:C0H3T7" /translation="MKVIRIILQVLILYVFFMIGEAIQHLFHLPVSGSIVGLVLLLIC LGLRIVPVSIIEDGAGFLLSFLPLLFIPAMTGVINYPSLISFNGLMLLITVVLSTIVT IIAAGFASQLLEKKAKKREEKEKCSKHVSRSL*" /label="yxzK CDS" gene 3610728..3611132 /gene="yxzK" /locus_tag="BSU_40021" /old_locus_tag="BSU40021" /label="yxzK gene" S_feature complement(3610749..3611801) /Source="Nicolas_S_feature" /locus_tag="new_4109864_4110916_c" /HighExp="Etha, C30, H2O2, Salt, Paraq, GM 120, Diami, Oxctl, G180, Sw" /AntisenseName="yxaC" /AntisenseCor="0.145103505386703" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1539" CDS 3611102..3611794 /gene="yxaC" /locus_tag="BSU_40022" /old_locus_tag="BSU40022" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15126464, 15849754, 16850406, 17452642, 26060272; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative murein hydrolase export regulator" /protein_id="NP_391882.3" /db_xref="EnsemblGenomes-Gn:BSU40022" /db_xref="EnsemblGenomes-Tr:CAB16039" /db_xref="GOA:P42102" /db_xref="InterPro:IPR007300" /db_xref="SubtiList:BG11105" /db_xref="UniProtKB/Swiss-Prot:P42102" /translation="MQQACIAIIIILLTVAAYLAMVKLYKRFPLPFLIPVLTTTILIV AALMMFHVSYEGYMIGGKWINSLLGPAVVALAYPLYKQWHIIVKHCVPILGGVLVGLC MGMISGLIFAEAFGIDHDLLLSILPKSITTPVAIQIAAGLGGVPSMTVVFVMIAGFSG VILGPLFLKWLRIRSSLGQGIALGSASHALGTSKALEYGELAVSMSSVSMTLCAVLGS FFGPLVVWLFHI*" /label="yxaC CDS" gene 3611102..3611794 /gene="yxaC" /locus_tag="BSU_40022" /old_locus_tag="BSU40022" /label="yxaC gene" CDS complement(3611834..3612865) /gene="yxaB" /locus_tag="BSU_40030" /old_locus_tag="BSU40030" /EC_number="2.-.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9298659, 18326573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exopolysaccharide pyruvyl transferase (biofilm formation)" /protein_id="NP_391883.3" /db_xref="EnsemblGenomes-Gn:BSU40030" /db_xref="EnsemblGenomes-Tr:CAB16040" /db_xref="GOA:P42101" /db_xref="InterPro:IPR007345" /db_xref="SubtiList:BG11104" /db_xref="UniProtKB/Swiss-Prot:P42101" /translation="MTVQEIKGKKLVKGIAPNVEPEALLNDKRKVFLFGSPSYTNIGD QAIAYAEEKFIKNHFPYYEYIEIMDYATDEGIELVKEIIREDDIVCFTGGGNLGNLYL DIEEDRRKVFSAFKDYKSISLPQSVYFEDTEEGQKEKKKTQDAYHQNTNLTIAARETQ TLDVVKETFNSNVIFTPDMVLSLDIVPRELERDGVLFILRADKEKVTDEDFISQMKQW AEKTTYTERTDTVLDTVDTIDYADREKHFMEMLDRIGSSKLVITDRLHAMIFSIITKT PCLVFGNSYGKAKHSYRDWLESLNFIEYTDKNDVEELERMIDRLLQAEPNDVDLSKDF QPLIDFFAS*" /label="yxaB CDS" gene complement(3611834..3612865) /gene="yxaB" /locus_tag="BSU_40030" /old_locus_tag="BSU40030" /label="yxaB gene" downshifts complement(3611846) /Source="Nicolas_upshifts" /id="D2071" /incds=0 /nref=5 /ntot=94 /MaxReadThrough="6.52386" /MaxDrop="4.6522" /score="17.8326496" /energy="-15.3" /TU="U3149" /idTUdmin="U3150" /TUdmin=220 /isTUend="FALSE" /label="downshifts" promotor_-35 3612832..3612835 /Source="Nicolas_upshift_promotors" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3612848 /Source="Nicolas_upshifts" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3612852..3612871 /Source="Nicolas_upshift_promotors" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3612902..3612920) /Source="Nicolas_upshift_promotors" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3612920) /Source="Nicolas_upshifts" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3612935..3612941) /Source="Nicolas_upshift_promotors" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3612958..3614106) /gene="glxK" /locus_tag="BSU_40040" /old_locus_tag="BSU40040" /EC_number="2.7.1.31" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15771780, 18326573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-glycerate kinase" /protein_id="NP_391884.2" /db_xref="EnsemblGenomes-Gn:BSU40040" /db_xref="EnsemblGenomes-Tr:CAB16041" /db_xref="GOA:P42100" /db_xref="InterPro:IPR004381" /db_xref="InterPro:IPR018193" /db_xref="InterPro:IPR036129" /db_xref="SubtiList:BG11103" /db_xref="UniProtKB/Swiss-Prot:P42100" /translation="MKIIIAPDSFKESLSALEAAEAIERGFKSVFPGADYRKLPVADG GEGTVQSLVDATNGRIIEQVVTGPLGEPVRAFFGMMGDGRTAVIEMAAASGLHLVPVD KRNPLITTTRGTGELIGAALDAGAERLIIGIGGSATNDGGAGMIQALGGRLLDNSGSE IGPGGGALSQLASIDVSGLDSRLRNVKLEVACDVDNPLTGPKGATAVFGPQKGATADM LDVLDQNVSHFADMAEKALGSTFRDTEGAGAAGGLGWSLLTYLQADLKRGIDIVLEAV DFESIVQDADLVITGEGRIDSQTVHGKTPIGVAKAAKSYDVPVIGIAGSISRDSNAVY QHGIDALFSIVPGAVPLEDAFEHAAEYMERTARDIAASIKLAKTMFLI*" /label="glxK CDS" gene complement(3612958..3614106) /gene="glxK" /locus_tag="BSU_40040" /old_locus_tag="BSU40040" /label="glxK gene" promotor_-10 complement(3614145..3614164) /Source="Nicolas_upshift_promotors" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3614156) /Source="Nicolas_upshifts" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3614175..3614182) /Source="Nicolas_upshift_promotors" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3614228..3614235 /Source="Nicolas_upshift_promotors" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3614249..3614268 /Source="Nicolas_upshift_promotors" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3614256 /Source="Nicolas_upshifts" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="upshifts" CDS 3614302..3615033 /gene="gntR" /locus_tag="BSU_40050" /old_locus_tag="BSU40050" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7476858, 7642511, 8655507, 9106211, 26151451" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7476858, 7642511, 8655507, 9106211, 26151451; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR-gluconate)" /protein_id="NP_391885.1" /db_xref="EnsemblGenomes-Gn:BSU40050" /db_xref="EnsemblGenomes-Tr:CAB16042" /db_xref="GOA:P10585" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10648" /db_xref="UniProtKB/Swiss-Prot:P10585" /translation="MLDSKDLLYPAKWLSKASTGVRVAYELRMRIVSGLIESGTILSE NTIAAEFSVSRSPVREALKILASEKIIRLERMGAVVIGLTEKKIAEIYDVRLLLETFV FERLVKIDIEPLVKDLSKILEMMKVSIKYEDADEFSFQDVLFHETIIRAIDHSYIQMI WNNLKPVMESFILLSMRVRLKEKYEDFTRILDNHELYIQAIKTKDRALMIQSLHQNFD DVQDKVEDLWLSQQMLAKGAEYNND*" /label="gntR CDS" gene 3614302..3615033 /gene="gntR" /locus_tag="BSU_40050" /old_locus_tag="BSU40050" /label="gntR gene" CDS 3615026..3616567 /gene="gntK" /locus_tag="BSU_40060" /old_locus_tag="BSU40060" /EC_number="2.7.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1659648, 2537826, 3020045, 11468405" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1659648, 2537826, 3020045, 11468405; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-gluconate kinase" /protein_id="NP_391886.1" /db_xref="EnsemblGenomes-Gn:BSU40060" /db_xref="EnsemblGenomes-Tr:CAB16043" /db_xref="GOA:P12011" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR006002" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10649" /db_xref="UniProtKB/Swiss-Prot:P12011" /translation="MTSYMLGIDIGTTSTKAVLFSENGDVVQKESIGYPLYTPDISTA EQNPEEIFQAVIHTTARITKQHPEKRISFISFSSAMHSVIAIDENDKPLTPCITWADN RSEGWAHKIKEELNGHEVYKRTGTPIHPMAPLSKIAWITNERKEIASKAKKYIGIKEY IFKQLFNEYVIDYSLASATGMMNLKGLDWDEEALRIAGITPDHLSKLVPTTEIFQHCS PEIAIQMGIDPETPFVIGASDGVLSNLGVNAIKKGEIAVTIGTSGAIRTIIDKPQTDE KGRIFCYALTDKHWVIGGPVNNGGIVLRWIRDEFASSEIETATRLGIDPYDVLTKIAQ RVRPGSDGLLFHPYLAGERAPLWNPDVRGSFFGLTMSHKKEHMIRAALEGVIYNLYTV FLALTECMDGPVTRIQATGGFARSEVWRQMMSDIFESEVVVPESYESSCLGACILGLY ATGKIDSFDAVSDMIGSTYRHTPIEDSAKEYRTLMPIFINLSRLLENQYTQIADYQRG LITHK*" /label="gntK CDS" gene 3615026..3616567 /gene="gntK" /locus_tag="BSU_40060" /old_locus_tag="BSU40060" /label="gntK gene" CDS 3616596..3617942 /gene="gntP" /locus_tag="BSU_40070" /old_locus_tag="BSU40070" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:3020045, 15849754, 1659648, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3020045, 15849754, 1659648, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="gluconate/proton permease" /protein_id="NP_391887.1" /db_xref="EnsemblGenomes-Gn:BSU40070" /db_xref="EnsemblGenomes-Tr:CAB16044" /db_xref="GOA:P12012" /db_xref="InterPro:IPR003474" /db_xref="SubtiList:BG10650" /db_xref="UniProtKB/Swiss-Prot:P12012" /translation="MPLIIVALGILALLFLIMGLKLNTFISLLVVSFGVALALGMPFD KVVSSIEAGIGGTLGHIALIFGLGAMLGKLIADSGGAQRIAMTLVNKFGEKNIQWAVV IASFIIGIALFFEVGLVLLIPIVFAISRELKISILFLGIPMVAALSVTHGFLPPHPGP TAIAGEYGANIGEVLLYGFIVAVPTVLIAGPLFTKFAKKIVPASFAKNGNIASLGTQK TFNLEETPGFGISVFTAMLPIIIMSVATIIDLLQETIGFADNGVLAFIRLIGNASTAM IISLLVAVYTMGIKRNIPVKTVMDSCSTAISQIGMMLLIIGGGGAFKQVLINGGVGDY VADLFKGTALSPIILAWLIAAILRISLGSATVAALSTTGLVIPLLGHSDVNLALVVLA TGAGSVIASHVNDAGFWMFKEYFGLSMKETFATWTLLETIISVAGLGFILLLSLVV*" /label="gntP CDS" gene 3616596..3617942 /gene="gntP" /locus_tag="BSU_40070" /old_locus_tag="BSU40070" /label="gntP gene" promotor_-35 3617395..3617399 /Source="Nicolas_upshift_promotors" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3617415..3617434 /Source="Nicolas_upshift_promotors" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3617424 /Source="Nicolas_upshifts" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="upshifts" CDS 3617965..3619371 /gene="gntZ" /locus_tag="BSU_40080" /old_locus_tag="BSU40080" /EC_number="1.1.1.343" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15231785, 9535092, 9931298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231785, 9535092, 9931298; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phosphogluconate dehydrogenase (NAD+-dependent)" /protein_id="NP_391888.1" /db_xref="EnsemblGenomes-Gn:BSU40080" /db_xref="EnsemblGenomes-Tr:CAB16045" /db_xref="GOA:P12013" /db_xref="InterPro:IPR006113" /db_xref="InterPro:IPR006114" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR006183" /db_xref="InterPro:IPR006184" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10651" /db_xref="UniProtKB/Swiss-Prot:P12013" /translation="MFNSIGVIGLGVMGSNIALNMANKGENVAVYNYTRDLTDQLIQK LDGQSLSPYYELEDFVQSLEKPRKIFLMVTAGKPVDSVIQSLKPLLEEGDVIMDGGNS HYEDTERRYDELKEKGIGYLGVGISGGEVGALTGPSIMPGGDRDVYEKAAPILTKIAA QVGDDPCCVYIGPKGAGHFTKMVHNGIEYADMQLIAEAYTFLRETLRLPLDEIASIFE TWNQGELKSYLIEITAEILRKKDEKTGQPLIDVILDKTGQKGTGKWTSMQAIDNGIPS TIITESLFARYLSSLKEERMAAQDVLAGPEAEEKHLDKDTWIEYVRQALYMGKVCAYA QGFAQYKMSSELYGWNLPLKDIALIFRGGCIIRADFLNVISEAFSEQPNLANLLIAPY FTDKLHAYQTGLRKVVCEGISTGISFPCLTTALSYYDGYRTGRSNANLLQAQRDYFGA HTYERTDMDGVFHTNWSE*" /label="gntZ CDS" gene 3617965..3619371 /gene="gntZ" /locus_tag="BSU_40080" /old_locus_tag="BSU40080" /label="gntZ gene" downshifts 3619360 /Source="Nicolas_upshifts" /id="D2072" /incds=0 /nref=128 /ntot=228 /MaxReadThrough="3.81668" /MaxDrop="5.52642" /score="20.2280166" /energy="-10.2" /TU="NA" /idTUdmin="U3151" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 3619468..3619487 /Source="Nicolas_upshift_promotors" /id="U3153" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=620 /SigmaFactorBS="tttttttcttctatcccaaacaacagaagacataagttatgt tttaaatatcataaacAGTGATACAATAATAGCTAGaaacaatccccaagatcatcat g" /listShort="S1540" /listLong="ahpC, ahpF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 3619470..3619761 /Source="Nicolas_S_feature" /locus_tag="new_4118585_4118876" /HighExp="S8, Etha, Sw, T0.30H, Cold, H2O2, B60, S5, S4, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1540" upshifts 3619470 /Source="Nicolas_upshifts" /id="U3153" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=620 /SigmaFactorBS="tttttttcttctatcccaaacaacagaagacataagttatgt tttaaatatcataaacAGTGATACAATAATAGCTAGaaacaatccccaagatcatcat g" /listShort="S1540" /listLong="ahpC, ahpF" /label="upshifts" promotor_-35 3619734..3619741 /Source="Nicolas_upshift_promotors" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3619756..3619775 /Source="Nicolas_upshift_promotors" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3619763 /Source="Nicolas_upshifts" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3619785..3619792 /Source="Nicolas_upshift_promotors" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3619807..3619826 /Source="Nicolas_upshift_promotors" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3619810) /Source="Nicolas_upshifts" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3619813..3619827) /Source="Nicolas_upshift_promotors" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3619822 /Source="Nicolas_upshifts" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3619835..3619839) /Source="Nicolas_upshift_promotors" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3619835..3620398 /gene="ahpC" /locus_tag="BSU_40090" /old_locus_tag="BSU40090" /EC_number="1.11.1.5" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8932315, 14766928, 26322180" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8932315, 14766928, 26322180; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkyl hydroperoxide reductase (small subunit)" /protein_id="NP_391889.1" /db_xref="EnsemblGenomes-Gn:BSU40090" /db_xref="EnsemblGenomes-Tr:CAB16046" /db_xref="GOA:P80239" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017559" /db_xref="InterPro:IPR019479" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11385" /db_xref="UniProtKB/Swiss-Prot:P80239" /translation="MSLIGKEVLPFEAKAFKNGEFIDVTNEDLKGQWSVFCFYPADFS FVCPTELEDLQEQYAALKELGVEVYSVSTDTHFVHKGWHDSSEKISKITYAMIGDPSQ TISRNFDVLDEETGLADRGTFIIDPDGVIQTVEINAGGIGRDASNLVNKVKAAQYVRQ NPGEVCPAKWEEGGETLTPSLDLVGKI*" /label="ahpC CDS" gene 3619835..3620398 /gene="ahpC" /locus_tag="BSU_40090" /old_locus_tag="BSU40090" /label="ahpC gene" CDS 3620412..3621941 /gene="ahpF" /locus_tag="BSU_40100" /old_locus_tag="BSU40100" /EC_number="1.6.99.3" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8932314, 14766928, 16232966, 23899494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8932314, 14766928, 16232966, 23899494; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkyl hydroperoxide reductase (large subunit)" /protein_id="NP_391890.1" /db_xref="EnsemblGenomes-Gn:BSU40100" /db_xref="EnsemblGenomes-Tr:CAB16047" /db_xref="GOA:P42974" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR002109" /db_xref="InterPro:IPR008255" /db_xref="InterPro:IPR012081" /db_xref="InterPro:IPR012336" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11204" /db_xref="UniProtKB/Swiss-Prot:P42974" /translation="MVLDANIKAQLNQYMQLIENDIVLKVSAGEDDTSKDMLALVDEL ASMSSKISVEKAELNRTPSFSVNRVGEDTGVTFAGIPLGHEFTSLVLALLQVSGRPPK VDQKVIDQVKKISGEYHFESYISLTCHNCPDVVQALNMMSVLNPNITHTMIDGAAYKA EVESKNIMAVPTVYLNGESFGSGRMTLEEILAKMGSGTDASEFADKEPFDVLVVGGGP AGASAAIYTARKGIRTGVVAERFGGQVLDTMSIENFISVKATEGPKLAASLEEHVKEY DIDVMNLQRAKRLEKKDLFELELENGAVLKSKTVILSTGARWRNVNVPGEQEFKNKGV AYCPHCDGPLFEGKDVAVIGGGNSGIEAAIDLAGIVNHVTVLEFAPELKADEVLQKRL YSLPNVTVVKNAQTKEITGDQSVNGITYVDRETGEEKHVELQGVFVQIGLVPNTEWLE GTVERNRMGEIIVDKHGATSVPGLFAAGDCTDSAYNQIIISMGSGATAALGAFDYLIR N*" /label="ahpF CDS" gene 3620412..3621941 /gene="ahpF" /locus_tag="BSU_40100" /old_locus_tag="BSU40100" /label="ahpF gene" downshifts complement(3621768) /Source="Nicolas_upshifts" /id="D2073" /incds=1 /nref=1 /ntot=9 /MaxReadThrough="3.25325" /MaxDrop="3.69049" /score="1.76901559" /energy="-18" /TU="NA" /idTUdmin="U3157" /TUdmin=198 /isTUend="FALSE" /label="downshifts" downshifts 3621934 /Source="Nicolas_upshifts" /id="D2074" /incds=0 /nref=248 /ntot=268 /MaxReadThrough="3.92009" /MaxDrop="8.88048" /score="33.1934883" /energy="-19.6" /TU="U3154" /idTUdmin="U3156" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3621967..3622050) /Source="Nicolas_S_feature" /locus_tag="new_4121082_4121165_c" /HighExp="G150, C30, LPhT, G135, S8, LBGstat, T0.30H, G180, Diami, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1541" downshifts complement(3622010) /Source="Nicolas_upshifts" /id="D2075" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="3.37922" /MaxDrop="4.44094" /score="1.76901559" /energy="-18" /TU="U3157" /idTUdmin="U3157" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(3622051..3623490) /gene="bglA" /locus_tag="BSU_40110" /old_locus_tag="BSU40110" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8125345, 14652714, 15139916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8125345, 14652714, 15139916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-6-phospho-beta-glucosidase" /protein_id="NP_391891.1" /db_xref="EnsemblGenomes-Gn:BSU40110" /db_xref="EnsemblGenomes-Tr:CAB16048" /db_xref="GOA:P42973" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG11203" /db_xref="UniProtKB/Swiss-Prot:P42973" /translation="MGNMPKDFLWGGALAAHQFEGGWNQGGKGPSVVDVMTAGAHGVP RKITDTIEENEFYPNHEAIDFYHRYKEDIALFAEMGLKCLRTSIGWSRIFPKGDEAEP NEAGLQFYDDVFDELLKHGIEPVITLSHFEMPLHLAREYGGFRNRKVVDFFVNFAEAC FTRYKDKVKYWMTFNEINNQMDVNNPLFLWTNSGVVVGENENAKEVMYQTAHHELVAS ALAVAKGKDINPEFQIGAMVSHVPIYPFSSNPEDVMLAEEEMRQRYFFPDVQVRGYYP SYALKEFEREGYNITFEDGDDEILRNGTVDYLGFSYYMSTTVKSDVKNDNTGDIVNGG LPNGVENPYITSSDWGWAIDPTGLRYTLNRFYDRYQIPLFIVENGFGAVDTLEEDGKV HDPERIQYLKSHIEALKKAVTYDGVDLIGYTPWGIIDIVSFTTGEMKKRYGMIYVDRD NEGNGSMKRYKKDSFEWYKNVIQTNGEEL*" /label="bglA CDS" gene complement(3622051..3623490) /gene="bglA" /locus_tag="BSU_40110" /old_locus_tag="BSU40110" /label="bglA gene" CDS complement(3623504..3623734) /gene="ptsJ" /locus_tag="BSU_40120" /old_locus_tag="BSU40120" /EC_number="2.7.1.-" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12867744, 28731580" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12867744, 28731580; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glucose phosphotransferase system enzyme IIA component" /protein_id="NP_391892.1" /db_xref="EnsemblGenomes-Gn:BSU40120" /db_xref="EnsemblGenomes-Tr:CAB16049" /db_xref="GOA:O32292" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR011055" /db_xref="SubtiList:BG14172" /db_xref="UniProtKB/Swiss-Prot:O32292" /translation="MVTPTKHAIGLRSASGVELLAHIGLDTVTFDGTPFSLKVKEGDT VKKGEVLVEFDKAFIEDIEESALHQKIFTVVS*" /label="ptsJ CDS" gene complement(3623504..3623734) /gene="ptsJ" /locus_tag="BSU_40120" /old_locus_tag="BSU40120" /label="ptsJ gene" S_feature complement(3623735..3623946) /Source="Nicolas_S_feature" /locus_tag="new_4122850_4123061_c" /HighExp="G150, LPhT, T0.30H, Diami, G135, LBGstat, G180, Oxctl, Lbexp, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1542" promotor_-10 complement(3623943..3623962) /Source="Nicolas_upshift_promotors" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3623948) /Source="Nicolas_upshifts" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3623977..3623984) /Source="Nicolas_upshift_promotors" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3624010..3624017 /Source="Nicolas_upshift_promotors" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3624028..3624047 /Source="Nicolas_upshift_promotors" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3624043 /Source="Nicolas_upshifts" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="upshifts" CDS 3624078..3624788 /gene="yydK" /locus_tag="BSU_40130" /old_locus_tag="BSU40130" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family)" /protein_id="NP_391893.1" /db_xref="EnsemblGenomes-Gn:BSU40130" /db_xref="EnsemblGenomes-Tr:CAB16050" /db_xref="GOA:Q45591" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3BWG" /db_xref="SubtiList:BG11484" /db_xref="UniProtKB/Swiss-Prot:Q45591" /translation="MLKYQQIATEIETYIEEHQLQQGDKLPVLETLMAQFEVSKSTIT KSLELLEQKGAIFQVRGSGIFVRKHKRKGYISLLSNQGFKKDLEDFNVTSKVIELDVR KPTPEAAENLNIGMDEDIYYVKRVRYINGQTLCYEESYYTKSIVTYLNNEIVSHSIFH YIREGLGLKIGFSDLFLHVGQLNEEEAEYLGLEAGLPKLYIESIFHLTNGQPFDYSKI SYNYEQSQFVVQANSFLL*" /label="yydK CDS" gene 3624078..3624788 /gene="yydK" /locus_tag="BSU_40130" /old_locus_tag="BSU40130" /label="yydK gene" CDS 3624816..3624974 /gene="yyzN" /locus_tag="BSU_40139" /old_locus_tag="BSU40139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097799.1" /db_xref="EnsemblGenomes-Gn:BSU40139" /db_xref="EnsemblGenomes-Tr:CAX52714" /db_xref="GOA:C0H3T8" /db_xref="UniProtKB/Swiss-Prot:C0H3T8" /translation="MYKIIIPAILAIFALWILLQISLEMSIVKNPMNYFIVFIIFFLF VKMVKEKQ*" /label="yyzN CDS" gene 3624816..3624974 /gene="yyzN" /locus_tag="BSU_40139" /old_locus_tag="BSU40139" /label="yyzN gene" downshifts 3625051 /Source="Nicolas_upshifts" /id="D2076" /incds=0 /nref=16 /ntot=177 /MaxReadThrough="0.96913" /MaxDrop="4.2349" /score="-9.95345673" /energy="-14.7" /TU="NA" /idTUdmin="U3158" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(3625105..3625827) /gene="liaM" /locus_tag="BSU_40140" /old_locus_tag="BSU40140" /function="16.1: Circulate" /function="16.3: Control" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type t : transporter" /codon_start=1 /transl_table=11 /product="permease for export of regulatory peptide LiaD*" /protein_id="NP_391894.1" /db_xref="EnsemblGenomes-Gn:BSU40140" /db_xref="EnsemblGenomes-Tr:CAB16051" /db_xref="GOA:Q45592" /db_xref="SubtiList:BG11483" /db_xref="UniProtKB/Swiss-Prot:Q45592" /translation="MKLEFKKSISNKVIIILGAMFVFLFLLGYFLLVGIDKVSNVTPE MFFFSSYTVATQFGLMLFSFVIAFFINREYSNKNILFYKLIGENIYTFFYKKIAVLFL ECFAFITLGLLIISLMYHDFSHFALLLFLFSAVILQYILIIGTISVLCPNILISIGVS IVYWMTSVILVAISNKTFGFIAPFEAGNTMYPRIERVLQSDNMTLGSNDVLFIILYLV SIIIINAIVLRFSKTRWIKMGL*" /label="liaM CDS" gene complement(3625105..3625827) /gene="liaM" /locus_tag="BSU_40140" /old_locus_tag="BSU40140" /label="liaM gene" downshifts complement(3625117) /Source="Nicolas_upshifts" /id="D2077" /incds=0 /nref=225 /ntot=267 /MaxReadThrough="2.70741" /MaxDrop="6.21099" /score="7.49162587" /energy="-10.5" /TU="NA" /idTUdmin="U3160" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-35 3625728..3625731 /Source="Nicolas_upshift_promotors" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3625747..3625751 /Source="Nicolas_upshift_promotors" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3625762 /Source="Nicolas_upshifts" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3625848..3626477) /gene="liaL" /locus_tag="BSU_40150" /old_locus_tag="BSU40150" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter for regulatory peptide LiaD* (ATP-binding protein)" /protein_id="NP_391895.1" /db_xref="EnsemblGenomes-Gn:BSU40150" /db_xref="EnsemblGenomes-Tr:CAB16052" /db_xref="GOA:Q45593" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11482" /db_xref="UniProtKB/Swiss-Prot:Q45593" /translation="MNIANYTLKVKGKTLLQDTDLHFSSGKINHVVGKNGVGKSQLAK DFLLNNSKRIGRDIRQNVSLISSSSNIPNDVSKDFLLHFLSKKFDAKMIDKIAYLLNL DNIDGKVLIKNLSDGQKQKLKLLSFLLEDKNIIVLDEITNSLDKKTVIEIHGFLNKYI QENPEKIIINITHDLSDLKAIEGDYYIFNHQEIQQYHSVDKLIEVYINE*" /label="liaL CDS" gene complement(3625848..3626477) /gene="liaL" /locus_tag="BSU_40150" /old_locus_tag="BSU40150" /label="liaL gene" S_feature complement(3626478..3626626) /Source="Nicolas_S_feature" /locus_tag="new_4125593_4125741_c" /HighExp="T-0.40H, LoTm, T-2.40H, T0.0H, M9-tran, SMMPr, T-1.40H, GM 150, T-3.40H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1543" CDS complement(3626627..3627385) /gene="liaK" /locus_tag="BSU_40160" /old_locus_tag="BSU40160" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane metalloprotease acting on modified factor LiaD" /protein_id="NP_391896.2" /db_xref="EnsemblGenomes-Gn:BSU40160" /db_xref="EnsemblGenomes-Tr:CAB16053" /db_xref="GOA:Q45594" /db_xref="SubtiList:BG11481" /db_xref="UniProtKB/Swiss-Prot:Q45594" /translation="MKILKYEDEKYEVLVQNNVFIKDKKSGEYYKNSLNSLSDKQLLR FKMYKEKVSPKFFYLFLSFTALMFILNYIHLIKLQNGLSSVFYGWKMWIIIVIYFIMN IVLHELGHIYSLKFFGKNFDKVGFKLNFYVFPAFYVQLNETYMLSRNEKIIVHLFGLF INYLLINTLELINQFTFSSEALTMAFMLFSSTLLWNLIPILNSDGYKILLAFLSLDEY SRFKTNHWLVLTIQIIGIGLAVNSVVHWILYIVN*" /label="liaK CDS" gene complement(3626627..3627385) /gene="liaK" /locus_tag="BSU_40160" /old_locus_tag="BSU40160" /label="liaK gene" promotor_-10 complement(3627075..3627094) /Source="Nicolas_upshift_promotors" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3627091) /Source="Nicolas_upshifts" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3627107..3627114) /Source="Nicolas_upshift_promotors" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3627366..3628325) /gene="liaE" /locus_tag="BSU_40170" /old_locus_tag="BSU40170" /EC_number="5.1.1.-" /experiment="publication(s) with functional evidences, PMID:17921301, 18307109, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17921301, 18307109, 28644475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="AdoMet radical amino acid epimerase modifying factor LiaD" /protein_id="NP_391897.1" /db_xref="EnsemblGenomes-Gn:BSU40170" /db_xref="EnsemblGenomes-Tr:CAB16054" /db_xref="GOA:Q45595" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR023904" /db_xref="InterPro:IPR034395" /db_xref="SubtiList:BG11480" /db_xref="UniProtKB/Swiss-Prot:Q45595" /translation="MYNKTVSINLDSRCNASCDHCCFSSSPTSTTRMEKEYIRELVTE FAKNKTIQVISFTGGEVFLDYKFLKELMEIIKPYEKQITLISNGFWGLSKKKVQEYFH DMNSLNVIALTISYDEYHAPFVKSSSIKNILEHSRKYPDIDISLNMAVTKDKMSNHIL EELGDSILGVKITKFPMISVGAAKTRIKQENIHKFYSLEDEDSLHCPGYDIVYHHDGE IYPCCSPAIFETKITLREEYNQSFERTVEKLNSNLLLFILRKEGFKWFLNILKENNKI EEFDIPYEFSSICGVCGSLFNSAEKINYFYPYMEKYYNENFKV*" /label="liaE CDS" gene complement(3627366..3628325) /gene="liaE" /locus_tag="BSU_40170" /old_locus_tag="BSU40170" /label="liaE gene" downshifts 3628314 /Source="Nicolas_upshifts" /id="D2078" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="3.40583" /MaxDrop="2.5017" /score="-9.12840375" /energy="-9.4" /TU="NA" /idTUdmin="U3161" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" misc_feature 3628361..3628364 /Source="Nicolas_upshift_promotors" /id="U3161" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.304695304695305" /xcortree=119 /SigmaFactorBS="actgttttattatacatgaaatatcccccaacaaatggtaaa ggagagttagACTCtcctttgtacccctctaattaatgaccacttccaagaatccagc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3628369 /Source="Nicolas_upshifts" /id="U3161" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.304695304695305" /xcortree=119 /SigmaFactorBS="actgttttattatacatgaaatatcccccaacaaatggtaaa ggagagttagACTCtcctttgtacccctctaattaatgaccacttccaagaatccagc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3628383..3628532) /gene="liaD" /locus_tag="BSU_40180" /old_locus_tag="BSU40180" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15101989, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 17921301, 28644475; Product type r: regulator" /codon_start=1 /transl_table=11 /product="precursor of exported modified peptide (epipeptide) controlling LiaRS activity" /protein_id="NP_391898.1" /db_xref="EnsemblGenomes-Gn:BSU40180" /db_xref="EnsemblGenomes-Tr:CAB16055" /db_xref="InterPro:IPR023898" /db_xref="SubtiList:BG11479" /db_xref="UniProtKB/Swiss-Prot:Q45596" /translation="MKKEITNNETVKNLEFKGLLDESQKLAKVNDLWYFVKSKENRWI LGSGH*" /label="liaD CDS" gene complement(3628383..3628532) /gene="liaD" /locus_tag="BSU_40180" /old_locus_tag="BSU40180" /label="liaD gene" downshifts complement(3628390) /Source="Nicolas_upshifts" /id="D2079" /incds=0 /nref=99 /ntot=172 /MaxReadThrough="7.62324" /MaxDrop="6.01674" /score="7.49162587" /energy="-10.5" /TU="U3163" /idTUdmin="U3167" /TUdmin=2794 /isTUend="FALSE" /label="downshifts" misc_feature 3628441..3628458 /Source="Nicolas_upshift_promotors" /id="U3162" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.342657342657343" /psig="0.342657342657343" /xcortree=651 /SigmaFactorBS="atgaccacttccaagaatccagcgattttcttttgattttac aaaataccaaagaTCATTCACTTTTGCTAACttttgtgattcatctaatagaccctta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3628446 /Source="Nicolas_upshifts" /id="U3162" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.342657342657343" /psig="0.342657342657343" /xcortree=651 /SigmaFactorBS="atgaccacttccaagaatccagcgattttcttttgattttac aaaataccaaagaTCATTCACTTTTGCTAACttttgtgattcatctaatagaccctta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3628527 /Source="Nicolas_upshifts" /id="D2080" /incds=0 /nref=99 /ntot=170 /MaxReadThrough="2.55247" /MaxDrop="5.95806" /score="-9.12840375" /energy="-9.4" /TU="NA" /idTUdmin="U3161" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3628553..3628572) /Source="Nicolas_upshift_promotors" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3628574) /Source="Nicolas_upshifts" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3628587..3628594) /Source="Nicolas_upshift_promotors" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3628867..3628874 /Source="Nicolas_upshift_promotors" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3628889..3628908 /Source="Nicolas_upshift_promotors" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3628893 /Source="Nicolas_upshifts" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="upshifts" CDS 3629004..3630929 /gene="fbp" /locus_tag="BSU_40190" /old_locus_tag="BSU40190" /EC_number="3.1.3.11" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:221467, 9696785, 19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 221467, 9696785, 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1,6-bisphosphatase" /protein_id="NP_391899.2" /db_xref="EnsemblGenomes-Gn:BSU40190" /db_xref="EnsemblGenomes-Tr:CAB16056" /db_xref="GOA:Q45597" /db_xref="InterPro:IPR009164" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11478" /db_xref="UniProtKB/Swiss-Prot:Q45597" /translation="MESKYLDLLAQKYDCEEKVVTEIINLKAILNLPKGTEHFVSDLH GEYQAFQHVLRNGSGRVKEKIRDIFSGVIYDREIDELAALVYYPEDKLKLIKHDFDAK EALNEWYKETIHRMIKLVSYCSSKYTRSKLRKALPAQFAYITEELLYKTEQAGNKEQY YSEIIDQIIELGQADKLITGLAYSVQRLVVDHLHVVGDIYDRGPQPDRIMEELINYHS VDIQWGNHDVLWIGAYSGSKVCLANIIRICARYDNLDIIEDVYGINLRPLLNLAEKYY DDNPAFRPKADENRPEDEIKQITKIHQAIAMIQFKLESPIIKRRPNFNMEERLLLEKI DYDKNEITLNGKTYQLENTCFATINPEQPDQLLEEEAEVIDKLLFSVQHSEKLGRHMN FMMKKGSLYLKYNGNLLIHGCIPVDENGNMETMMIEDKPYAGRELLDVFERFLREAFA HPEETDDLATDMAWYLWTGEYSSLFGKRAMTTFERYFIKEKETHKEKKNPYYYLREDE ATCRNILAEFGLNPDHGHIINGHTPVKEIEGEDPIKANGKMIVIDGGFSKAYQSTTGI AGYTLLYNSYGMQLVAHKHFNSKAEVLSTGTDVLTVKRLVDKELERKKVKETNVGEEL LQEVAILESLREYRYMK*" /label="fbp CDS" gene 3629004..3630929 /gene="fbp" /locus_tag="BSU_40190" /old_locus_tag="BSU40190" /label="fbp gene" S_feature 3630930..3632294 /Source="Nicolas_S_feature" /locus_tag="new_4130045_4131409" /HighExp="Lbstat, dia5, C30, Gly, Etha, dia15, C90, Fru, G135, Mal" /AntisenseName="yydD" /AntisenseCor="0.44422072328838003" /AntisenseRegPval="-13.7" /CDS_PredictionProba="0.22050400000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1544" S_feature complement(3631142..3631462) /Source="Nicolas_S_feature" /locus_tag="new_4130257_4130577_c" /HighExp="Cold, C30, M/G, S8, Fru, nit, Glu, BMM, Heat, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1545" CDS complement(3631463..3633223) /gene="yydD" /locus_tag="BSU_40200" /old_locus_tag="BSU40200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative DNA wielding protein" /protein_id="NP_391900.1" /db_xref="EnsemblGenomes-Gn:BSU40200" /db_xref="EnsemblGenomes-Tr:CAB16057" /db_xref="InterPro:IPR018760" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11477" /db_xref="UniProtKB/Swiss-Prot:Q45598" /translation="MIVMIIKNLFVCNSQEILKEYKFNAVGVNIILGEKREDHEETNG VGKSTMIECISFLLGKTISNFYTTNEILLNKNVFIVLNVEIDGNQVFLARSFNSPKHG YTLHDTSLTFNLEEWKKVSISVYKKFIEKEILKGEKEDITFAALREYIIRDEKTGFND IVLPNRGGLKQYKLLNYLFTLPTHTEKNIKVFRDKIEKLNSEIKLIESMNINIGDLKV KEDELINEIEDYNRVIYQTKTANKYNNDTNRYSEIKSELNKIQNEIFENEHICKQYQR NIDDLNKKVTKIKELENIEKFYEDIVGFFPEEVKQNYNKVQEFYNFMVESRGSYFKDK IVKIQADLKKLNIKKQGLTEQLESSARILKSNNFIEDISIVMEEQRRKEIELAEVRLR ISDYDKKNHIFDKINELQHEILRVNSMYYDEFQSYSAIVSELKKLFNNLMDVTYNQHG FLDFEYDNRISNAKQSTTGRIKISCSIPDERSHGRLHMKINIFDLTWFLYRCINKCSL NILIHDGSYSNPDPHVKGTLLKHINSSLLENRIGQYFVTINKNELLLDDLQELESKGM IVAKLDRNNEDKNRFFGFRF*" /label="yydD CDS" gene complement(3631463..3633223) /gene="yydD" /locus_tag="BSU_40200" /old_locus_tag="BSU40200" /label="yydD gene" downshifts complement(3631506) /Source="Nicolas_upshifts" /id="D2081" /incds=0 /nref=11 /ntot=199 /MaxReadThrough="4.99391" /MaxDrop="4.47843" /score="7.49162587" /energy="-10.5" /TU="U3167" /idTUdmin="U3167" /TUdmin="-322" /isTUend="FALSE" /label="downshifts" misc_feature 3632291..3632292 /Source="Nicolas_upshift_promotors" /id="U3165" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.67032967032967" /psig="0.255744255744256" /xcortree=83 /SigmaFactorBS="aactccctctactttctaccatgaaattatagaactcttgga ctttattataattCTgttttacttcctctggaaaaaaacctacaatatcttcatagaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3632296 /Source="Nicolas_upshifts" /id="U3165" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.67032967032967" /psig="0.255744255744256" /xcortree=83 /SigmaFactorBS="aactccctctactttctaccatgaaattatagaactcttgga ctttattataattCTgttttacttcctctggaaaaaaacctacaatatcttcatagaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3633223..3633621) /gene="yydC" /locus_tag="BSU_40210" /old_locus_tag="BSU40210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391901.1" /db_xref="EnsemblGenomes-Gn:BSU40210" /db_xref="EnsemblGenomes-Tr:CAB16058" /db_xref="SubtiList:BG11476" /db_xref="UniProtKB/Swiss-Prot:Q45599" /translation="MIDLKIETAENILKYSYVLLENEFKNIQIGNDLIPLVNNSPLKK EKAERPEMNHFLLTKYNAVEENILYSSKILYELLEKEKHIDQLFLDYAKSQGIIINLN IERILYLSLTFLYSLGKVSFNQNMISRTES*" /label="yydC CDS" gene complement(3633223..3633621) /gene="yydC" /locus_tag="BSU_40210" /old_locus_tag="BSU40210" /label="yydC gene" CDS complement(3633614..3635059) /gene="yydB" /locus_tag="BSU_40220" /old_locus_tag="BSU40220" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphohydrolase" /protein_id="NP_391902.1" /db_xref="EnsemblGenomes-Gn:BSU40220" /db_xref="EnsemblGenomes-Tr:CAB16059" /db_xref="GOA:Q45600" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11475" /db_xref="UniProtKB/Swiss-Prot:Q45600" /translation="MKVRFLQISDLHFQFQNYDTIVMRDKLLDFIEVLRRESDFDFLL LTGDIAHKGDVYNEDVKEYLNGIIKSMGLSKNNVHLVPGNHDISRDMTRTLLIDSIMK SPNPSEMLDKLDQKATNILVEGQRKFFDFYEDFMGVKYPEEDLHFLYQSEKYNVLSIN TCLLSDKKGEEGTLLTAQMKLYKAIRKMNKEKNKGKVLNIAIGHHTLGCIESSERESI KAHFDDYFIDLYLAGHVHDSSFNITANTNENPFLELVSGAIIKDEYATPEFISVDVNL DNGETEVTYYIWNTEYKYWSKNNQGGRRLQEGKLNYKINRLESLIEKEIEDNDDKIDE DEFKSFIIDFHEYRESYKTFTSNFDNQIGLDKKFYDMKSGETFKRKFDSYSEYFGVIN HIMDSTSYVSADKKELIAETIVDKYLEFHNQYNNGDEIFVKIVNEIYLECHSVLPYSK ALTKKYIKILTCWCIYECEIFNDNKRSVKND*" /label="yydB CDS" gene complement(3633614..3635059) /gene="yydB" /locus_tag="BSU_40220" /old_locus_tag="BSU40220" /label="yydB gene" promotor_-35 3634309..3634316 /Source="Nicolas_upshift_promotors" /id="U3166" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.353646353646354" /psig="0.430569430569431" /xcortree=94 /SigmaFactorBS="tttataatggctccacttactaattctaagaATGGATTTtca tttgtattTGCAGTAATATTAAATGAAGaatcatgtacatgtcctgccaaatatagat c" /listShort="S1546" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3634328..3634347 /Source="Nicolas_upshift_promotors" /id="U3166" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.353646353646354" /psig="0.430569430569431" /xcortree=94 /SigmaFactorBS="tttataatggctccacttactaattctaagaATGGATTTtca tttgtattTGCAGTAATATTAAATGAAGaatcatgtacatgtcctgccaaatatagat c" /listShort="S1546" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3634338..3635387 /Source="Nicolas_S_feature" /locus_tag="new_4133453_4134502" /HighExp="C30, Salt, Gly, S8, Etha, LPhT, T0.30H, Heat, C90, M9-stat" /AntisenseName="yydB" /AntisenseCor="0.36202116146901597" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.431" /TUlongSig="NA" /TUlongPSig="NA" /label="S1546" upshifts 3634338 /Source="Nicolas_upshifts" /id="U3166" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.353646353646354" /psig="0.430569430569431" /xcortree=94 /SigmaFactorBS="tttataatggctccacttactaattctaagaATGGATTTtca tttgtattTGCAGTAATATTAAATGAAGaatcatgtacatgtcctgccaaatatagat c" /listShort="S1546" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3635060..3635320) /Source="Nicolas_S_feature" /locus_tag="new_4134175_4134435_c" /HighExp="Cold, M0t90, Lbtran, M40t90, Lbstat, T0.30H, MG 150, M40t45, Gly, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1547" CDS complement(3635321..3635800) /gene="rlmH" /locus_tag="BSU_40230" /old_locus_tag="BSU40230" /EC_number="2.1.1.177" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 18755835, 20817755, 22411911, 22720735, 28428565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA (pseudouridine1915-N3)-methyltransferase" /protein_id="NP_391903.1" /db_xref="EnsemblGenomes-Gn:BSU40230" /db_xref="EnsemblGenomes-Tr:CAB16060" /db_xref="GOA:Q45601" /db_xref="InterPro:IPR003742" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="PDB:1TO0" /db_xref="SubtiList:BG11474" /db_xref="UniProtKB/Swiss-Prot:Q45601" /translation="MNINIVTIGKLKEKYLKQGIEEYTKRLSAYAKIDIIELPDEKAP ENLSDQDMKIIKDKEGDRILSKISPDAHVIALAIEGKMKTSEELADTIDKLATYGKSK VTFVIGGSLGLSDTVMKRADEKLSFSKMTFPHQLMRLILVEQIYRAFRINRGEPYHK* " /label="rlmH CDS" gene complement(3635321..3635800) /gene="rlmH" /locus_tag="BSU_40230" /old_locus_tag="BSU40230" /label="rlmH gene" S_feature complement(3635801..3635880) /Source="Nicolas_S_feature" /locus_tag="new_4134916_4134995_c" /HighExp="dia5, LBGtran, T0.30H, Diami, Cold, M0t90, dia0, M0t45, M40t45, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1548" CDS complement(3635881..3636051) /gene="yyzF" /locus_tag="BSU_40239" /old_locus_tag="BSU40239" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097800.1" /db_xref="EnsemblGenomes-Gn:BSU40239" /db_xref="EnsemblGenomes-Tr:CAX52715" /db_xref="InterPro:IPR025626" /db_xref="UniProtKB/Swiss-Prot:C0H3T9" /translation="MKQAYYSCEEHIETVLDMYIDDHELPPEIRKIEHTNSLSTACEL CGDPAVYIVGNE*" /label="yyzF CDS" gene complement(3635881..3636051) /gene="yyzF" /locus_tag="BSU_40239" /old_locus_tag="BSU40239" /label="yyzF gene" promotor_-10 complement(3636092..3636111) /Source="Nicolas_upshift_promotors" /id="U3167" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.343656343656344" /psig="0.988011988011988" /xcortree=2306 /SigmaFactorBS="ttgtttgtcgaattgtggataaaactcagcccgaagcaCTAC TAacatgtgaataaaTAGGTTATATTGAGAAGAGAacatttgtaaaaatggaagaaaa c" /listShort="yyzF, S1548, yydA, S1547, yydB, yydC, yydD, S1545" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3636108) /Source="Nicolas_upshifts" /id="U3167" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.343656343656344" /psig="0.988011988011988" /xcortree=2306 /SigmaFactorBS="ttgtttgtcgaattgtggataaaactcagcccgaagcaCTAC TAacatgtgaataaaTAGGTTATATTGAGAAGAGAacatttgtaaaaatggaagaaaa c" /listShort="yyzF, S1548, yydA, S1547, yydB, yydC, yydD, S1545" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3636125..3636130) /Source="Nicolas_upshift_promotors" /id="U3167" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.343656343656344" /psig="0.988011988011988" /xcortree=2306 /SigmaFactorBS="ttgtttgtcgaattgtggataaaactcagcccgaagcaCTAC TAacatgtgaataaaTAGGTTATATTGAGAAGAGAacatttgtaaaaatggaagaaaa c" /listShort="yyzF, S1548, yydA, S1547, yydB, yydC, yydD, S1545" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3636174..3636181 /Source="Nicolas_upshift_promotors" /id="U3168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.994005994005994" /xcortree=415 /SigmaFactorBS="ccacaattcgacaaacaagctgtTGATGACTctatttcgctc gTGTGTTAGTTTGGATGTAACcgatgtgtggggaggtctgcatttgcgctttagatgg g" /listShort="yycS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3636194..3636213 /Source="Nicolas_upshift_promotors" /id="U3168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.994005994005994" /xcortree=415 /SigmaFactorBS="ccacaattcgacaaacaagctgtTGATGACTctatttcgctc gTGTGTTAGTTTGGATGTAACcgatgtgtggggaggtctgcatttgcgctttagatgg g" /listShort="yycS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3636211 /Source="Nicolas_upshifts" /id="U3168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.994005994005994" /xcortree=415 /SigmaFactorBS="ccacaattcgacaaacaagctgtTGATGACTctatttcgctc gTGTGTTAGTTTGGATGTAACcgatgtgtggggaggtctgcatttgcgctttagatgg g" /listShort="yycS" /GFF_Attribute="listLong" /label="upshifts" CDS 3636236..3636649 /gene="yycS" /locus_tag="BSU_40240" /old_locus_tag="BSU40240" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21911367; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391904.1" /db_xref="EnsemblGenomes-Gn:BSU40240" /db_xref="EnsemblGenomes-Tr:CAB16061" /db_xref="SubtiList:BG11472" /db_xref="UniProtKB/Swiss-Prot:Q45603" /translation="MRFRWVWLFVIMLLLAECQPSYWVLEKDRIGEGSPDLEIYANYL QMHDDVKGYQVFTISEGKKMVVVSLGSSEKDKKLEVSDVKFSSKETIVTVERKPAPTA NEKNPFILIGLDKIEGDLIVQDETGDRFEETDYQQ*" /label="yycS CDS" gene 3636236..3636649 /gene="yycS" /locus_tag="BSU_40240" /old_locus_tag="BSU40240" /label="yycS gene" downshifts 3636629 /Source="Nicolas_upshifts" /id="D2082" /incds=0 /nref=17 /ntot=131 /MaxReadThrough="1.50241" /MaxDrop="5.73792" /score="16.0382598" /energy="-10.8" /TU="NA" /idTUdmin="U3168" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3636683..3637909) /gene="yycR" /locus_tag="BSU_40250" /old_locus_tag="BSU40250" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18820069; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase" /protein_id="NP_391905.1" /db_xref="EnsemblGenomes-Gn:BSU40250" /db_xref="EnsemblGenomes-Tr:CAB16062" /db_xref="GOA:Q45604" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR014184" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11471" /db_xref="UniProtKB/Swiss-Prot:Q45604" /translation="MGGMALTGNKAVVYKGKGTVAVEDIGYPELILRDGPGVPKANVN RKCEHGVILKVITTNICGSDQHMVRGRTTAPEGLVLGHEITGEVIETGRDVEFIKKGD IVSVPFNIACGRCVMCKTQKTHVCLNVNPDRPGSAYGYVDMGGWVGGQSEYVMVPYAD FQLLVFPDKEQALEKILDLTMLSDIFPTGFHGAYTAGVQTGSTVYIAGAGPVGLAAAH SAQLLGASTVIVGDLNEDRLAQARSFGCETVNVQKHDRLGEQIEQILGEPTVDAAVDC VGFEASGHGNQGEAPAAVLNSIMDVTQVGGSLGIPGLYVTEDPGAKDADAKTGSLKIR FGLGWAKAHTFVTGQTPAMTYNRNLMKAILSGRAQIAKAVNATVISLDDAPKGYSDFD KGAAKKFVIDPHGTLK*" /label="yycR CDS" gene complement(3636683..3637909) /gene="yycR" /locus_tag="BSU_40250" /old_locus_tag="BSU40250" /label="yycR gene" downshifts complement(3636698) /Source="Nicolas_upshifts" /id="D2083" /incds=0 /nref=9 /ntot=123 /MaxReadThrough="0.14321" /MaxDrop="4.77892" /score="8.82768619" /energy="-6.2" /TU="NA" /idTUdmin="U3169" /TUdmin=7 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3637932..3637950) /Source="Nicolas_upshift_promotors" /id="U3169" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=518 /SigmaFactorBS="taagaatacagaaaaaacagtcgtgaaAAAGGGAAAgagtca tgccgAACCGAAGTCATGTTCAAGgacggagagtccaaacacatgaatgggaggaatg g" /listShort="yycR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3637937) /Source="Nicolas_upshifts" /id="U3169" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=518 /SigmaFactorBS="taagaatacagaaaaaacagtcgtgaaAAAGGGAAAgagtca tgccgAACCGAAGTCATGTTCAAGgacggagagtccaaacacatgaatgggaggaatg g" /listShort="yycR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3637962..3637970) /Source="Nicolas_upshift_promotors" /id="U3169" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=518 /SigmaFactorBS="taagaatacagaaaaaacagtcgtgaaAAAGGGAAAgagtca tgccgAACCGAAGTCATGTTCAAGgacggagagtccaaacacatgaatgggaggaatg g" /listShort="yycR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3637972..3638142) /gene="yyzG" /locus_tag="BSU_40259" /old_locus_tag="BSU40259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097801.1" /db_xref="EnsemblGenomes-Gn:BSU40259" /db_xref="EnsemblGenomes-Tr:CAX52716" /db_xref="GOA:C0H3U0" /db_xref="UniProtKB/Swiss-Prot:C0H3U0" /translation="MQTNRVILLAVMICLVSAITVFLLNGCKVDFLDIGGTIIGCFLG IFVVVRIQKKQS*" /label="yyzG CDS" gene complement(3637972..3638142) /gene="yyzG" /locus_tag="BSU_40259" /old_locus_tag="BSU40259" /label="yyzG gene" promotor_-10 complement(3638161..3638179) /Source="Nicolas_upshift_promotors" /id="U3170" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.681318681318681" /psig="0.681318681318681" /xcortree=259 /SigmaFactorBS="ttatgaagagactggtgtgaagtctctttttttgttgaacCG AAGTTtgcagaggattttGGGTATGGTTTAGAAACGAatccaaaggaggaattacatg c" /listShort="yyzG, yycR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3638179) /Source="Nicolas_upshifts" /id="U3170" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.681318681318681" /psig="0.681318681318681" /xcortree=259 /SigmaFactorBS="ttatgaagagactggtgtgaagtctctttttttgttgaacCG AAGTTtgcagaggattttGGGTATGGTTTAGAAACGAatccaaaggaggaattacatg c" /listShort="yyzG, yycR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3638193..3638199) /Source="Nicolas_upshift_promotors" /id="U3170" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.681318681318681" /psig="0.681318681318681" /xcortree=259 /SigmaFactorBS="ttatgaagagactggtgtgaagtctctttttttgttgaacCG AAGTTtgcagaggattttGGGTATGGTTTAGAAACGAatccaaaggaggaattacatg c" /listShort="yyzG, yycR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3638247..3638495) /gene="yycQ" /locus_tag="BSU_40260" /old_locus_tag="BSU40260" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_391906.1" /db_xref="EnsemblGenomes-Gn:BSU40260" /db_xref="EnsemblGenomes-Tr:CAB16063" /db_xref="GOA:Q45605" /db_xref="InterPro:IPR020258" /db_xref="SubtiList:BG11470" /db_xref="UniProtKB/Swiss-Prot:Q45605" /translation="MGAIAVLFIVFGFPIVAGVFGIAGHFLFKRFWVAPLIVLITSLI LLVTLASGNSSFIFWVVMYTAIALVTSVATLFLRKFFE*" /label="yycQ CDS" gene complement(3638247..3638495) /gene="yycQ" /locus_tag="BSU_40260" /old_locus_tag="BSU40260" /label="yycQ gene" CDS complement(3638511..3639674) /gene="yycP" /locus_tag="BSU_40270" /old_locus_tag="BSU40270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11557812, 16291680" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391907.2" /db_xref="EnsemblGenomes-Gn:BSU40270" /db_xref="EnsemblGenomes-Tr:CAB16064" /db_xref="InterPro:IPR011047" /db_xref="SubtiList:BG11469" /db_xref="UniProtKB/Swiss-Prot:Q45606" /translation="MKKWMITIAMLILAGIALFVFISPLKSHKTVSQQDLRNPDFLDD KEVLLYFSSSADQDAFGGGKSYALFISHDGTLSSFQMKGLELGSAKVHGDSVMLEDKN TIYTIKNGLRSHKRTYQHTGDSAGFLQNTDGFYTLYNSGYDKKGDGYRSELYRQMDGE WKKDVIPYYIRASGFHDGAIYALVPTDDGKGYQLLQIQADQKKLTYLSITEWQYREGA SVESQLAVDDQAVYVMVRGQKAHDLYQMVKINKKSGEVELHDIAEYKNDEQTIYSSMP FSFKNSFFPYDGNLYFIDGFGKVHKIDAKTGKTSIVFTLSPDKMKAEFKEITQKGSSL YFFTYTYHKPAYIEQYSLKTGKKMKEKEIGKVKDVVTPKSHLKLYDVEVMKRF*" /label="yycP CDS" gene complement(3638511..3639674) /gene="yycP" /locus_tag="BSU_40270" /old_locus_tag="BSU40270" /label="yycP gene" promotor_-10 complement(3638545..3638563) /Source="Nicolas_upshift_promotors" /id="U3171" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=531 /SigmaFactorBS="cggaaagaaaatgaaagaaaaagagattggGAAGGTAAAgga tgtcgtgaCGCCGAAGAGTCATTTGAAgctgtatgatgttgaggtgatgaagaggttt t" /listShort="yycQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3638553) /Source="Nicolas_upshifts" /id="U3171" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=531 /SigmaFactorBS="cggaaagaaaatgaaagaaaaagagattggGAAGGTAAAgga tgtcgtgaCGCCGAAGAGTCATTTGAAgctgtatgatgttgaggtgatgaagaggttt t" /listShort="yycQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3638575..3638583) /Source="Nicolas_upshift_promotors" /id="U3171" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=531 /SigmaFactorBS="cggaaagaaaatgaaagaaaaagagattggGAAGGTAAAgga tgtcgtgaCGCCGAAGAGTCATTTGAAgctgtatgatgttgaggtgatgaagaggttt t" /listShort="yycQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3639685..3640422) /gene="yycO" /locus_tag="BSU_40280" /old_locus_tag="BSU40280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16291680" /codon_start=1 /transl_table=11 /product="conserved exported protein" /protein_id="NP_391908.1" /db_xref="EnsemblGenomes-Gn:BSU40280" /db_xref="EnsemblGenomes-Tr:CAB16065" /db_xref="SubtiList:BG11468" /db_xref="UniProtKB/Swiss-Prot:Q45607" /translation="MKLKKRVSMFLVALTMCGGLFVTPAKAVKTTNYAEEIAALQPGT TPEEIMKSASQIAKQQHVKQDVILKQFYKEITADKAEGDRLAKESGMSIMGGSSGTKK LPTSAKGNIYYTNSYTAYYNHGHVGMYSAADKIVESVPSDGVRQIAYNARDVEDNSIV QTVSVSSSQKTAAADWAVSKVGDPYSFNFVNNRNTGHDGAKNCSKLLWSAFLLKAGID IDSNGGLGVYPRDITSSSYTTTIMTIY*" /label="yycO CDS" gene complement(3639685..3640422) /gene="yycO" /locus_tag="BSU_40280" /old_locus_tag="BSU40280" /label="yycO gene" promotor_-10 complement(3640464..3640482) /Source="Nicolas_upshift_promotors" /id="U3172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.511488511488511" /psig="0.511488511488511" /xcortree=1227 /SigmaFactorBS="acgatttctaaaaattctgtaaataaCCTAGTTACtttcctt attttcCTAATATAATGTGGGTGAGgaaattacctttcctacactcacaagaaaagag g" /listShort="yycO, yycP, yycQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3640470) /Source="Nicolas_upshifts" /id="U3172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.511488511488511" /psig="0.511488511488511" /xcortree=1227 /SigmaFactorBS="acgatttctaaaaattctgtaaataaCCTAGTTACtttcctt attttcCTAATATAATGTGGGTGAGgaaattacctttcctacactcacaagaaaagag g" /listShort="yycO, yycP, yycQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3640496..3640504) /Source="Nicolas_upshift_promotors" /id="U3172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.511488511488511" /psig="0.511488511488511" /xcortree=1227 /SigmaFactorBS="acgatttctaaaaattctgtaaataaCCTAGTTACtttcctt attttcCTAATATAATGTGGGTGAGgaaattacctttcctacactcacaagaaaagag g" /listShort="yycO, yycP, yycQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3640564..3641034) /gene="yycN" /locus_tag="BSU_40290" /old_locus_tag="BSU40290" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14635137, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_391909.1" /db_xref="EnsemblGenomes-Gn:BSU40290" /db_xref="EnsemblGenomes-Tr:CAB16066" /db_xref="GOA:O32293" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1ON0" /db_xref="PDB:1UFH" /db_xref="SubtiList:BG11467" /db_xref="UniProtKB/Swiss-Prot:O32293" /translation="MTIMLTPMQTEEFRSYLTYTTKHYAEEKVKAGTWLPEDAQLLSK QVFTDLLPRGLETPHHHLWSLKLNEKDIVGWLWIHAEPEHPQQEAFIYDFGLYEPYRG KGYAKQALAALDQAARSMGIRKLSLHVFAHNQTARKLYEQTGFQETDVVMSKKL*" /label="yycN CDS" gene complement(3640564..3641034) /gene="yycN" /locus_tag="BSU_40290" /old_locus_tag="BSU40290" /label="yycN gene" downshifts complement(3640577) /Source="Nicolas_upshifts" /id="D2084" /incds=0 /nref=1 /ntot=78 /MaxReadThrough="3.78599" /MaxDrop="2.94893" /score="8.04802973" /energy="-7.6" /TU="U3175" /idTUdmin="U3174" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3641035..3641105) /Source="Nicolas_S_feature" /locus_tag="new_4140150_4140220_c" /HighExp="S4, S5, S6, LoTm, S3, S7, S8, B36, BT, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1549" promotor_-35 3641066..3641072 /Source="Nicolas_upshift_promotors" /id="U3173" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.551448551448551" /psig="0.995004995004995" /xcortree=3163 /SigmaFactorBS="attgtcatatcatctctccttcatatattgactagaggaTTT TACAtaaaatagaaagaGGTGTTACTATCAGAATAAGcaactgagattgataagtcac t" /listShort="rapG, phrG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3641086..3641105 /Source="Nicolas_upshift_promotors" /id="U3173" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.551448551448551" /psig="0.995004995004995" /xcortree=3163 /SigmaFactorBS="attgtcatatcatctctccttcatatattgactagaggaTTT TACAtaaaatagaaagaGGTGTTACTATCAGAATAAGcaactgagattgataagtcac t" /listShort="rapG, phrG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3641087..3641106) /Source="Nicolas_upshift_promotors" /id="U3174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.67032967032967" /psig="0.997002997002997" /xcortree=3164 /SigmaFactorBS="tgcgggtgcgatcttattcatgtgaaactcctttctcTAGTG ACTtatcaatctcagttGCTTATTCTGATAGTAACACctctttctattttatgtaaaa t" /listShort="S1549, yycN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3641087 /Source="Nicolas_upshifts" /id="U3173" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.551448551448551" /psig="0.995004995004995" /xcortree=3163 /SigmaFactorBS="attgtcatatcatctctccttcatatattgactagaggaTTT TACAtaaaatagaaagaGGTGTTACTATCAGAATAAGcaactgagattgataagtcac t" /listShort="rapG, phrG" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3641105) /Source="Nicolas_upshifts" /id="U3174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.67032967032967" /psig="0.997002997002997" /xcortree=3164 /SigmaFactorBS="tgcgggtgcgatcttattcatgtgaaactcctttctcTAGTG ACTtatcaatctcagttGCTTATTCTGATAGTAACACctctttctattttatgtaaaa t" /listShort="S1549, yycN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3641107..3641382) /Source="Nicolas_S_feature" /locus_tag="new_4140222_4140497_c" /HighExp="S4, S5, S6, S7, S8, S3, B36, BT, LoTm, T5.0H" /AntisenseName="rapG" /AntisenseCor="-0.20647217228472101" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1550" promotor_-35 complement(3641121..3641128) /Source="Nicolas_upshift_promotors" /id="U3174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.67032967032967" /psig="0.997002997002997" /xcortree=3164 /SigmaFactorBS="tgcgggtgcgatcttattcatgtgaaactcctttctcTAGTG ACTtatcaatctcagttGCTTATTCTGATAGTAACACctctttctattttatgtaaaa t" /listShort="S1549, yycN" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3641145..3642242 /gene="rapG" /locus_tag="BSU_40300" /old_locus_tag="BSU40300" /EC_number="3.1.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12950930, 16553878" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12950930, 16553878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391910.1" /db_xref="EnsemblGenomes-Gn:BSU40300" /db_xref="EnsemblGenomes-Tr:CAB16067" /db_xref="GOA:O32294" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11466" /db_xref="UniProtKB/Swiss-Prot:O32294" /translation="MNKIAPAEIASMLNDWYLAIKKHEVEESSRLFEEVKPLLDDMEE DQEVLAYFSLLELRHKVLLHEARGQGFQHEEPSHMNATSDMLKYYFFLFEGMYEAYKN NYDIAIGLYKDAEQYLDNIPDPIEKAEFHLKVGKLYYKLGQNIVSLNHTRQAVKTFRE ETDYKKKLASALITMSGNFTEMSQFEEAEAYLDEAIRITSELEDHFFEAQLLHNFGLL HAQSGKSEEAVSKLEEALQNDEYARSAYYYHSAYLLIRELFKIKKKEQALSYYQDVKE KLTAEPNRICEAKIDILYAIYAEGGHAETFHLCKQHMDDLLSEKEYDSVRELSILAGE RYRELELYKEAAHFFYEALQIEELIKRTEVI*" /label="rapG CDS" gene 3641145..3642242 /gene="rapG" /locus_tag="BSU_40300" /old_locus_tag="BSU40300" /label="rapG gene" promotor_-10 complement(3641373..3641391) /Source="Nicolas_upshift_promotors" /id="U3175" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1127 /SigmaFactorBS="aggcctcatacatgccttcaaacagaaaaaaGTAATAtttca gcatgtcagACGTAGCATTCATATGAGAaggctcctcatgctgaaagccctgtcctct c" /listShort="S1550, S1549, yycN, yycO, yycP" /listLong="yycQ" /label="promotor_-10" upshifts complement(3641382) /Source="Nicolas_upshifts" /id="U3175" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1127 /SigmaFactorBS="aggcctcatacatgccttcaaacagaaaaaaGTAATAtttca gcatgtcagACGTAGCATTCATATGAGAaggctcctcatgctgaaagccctgtcctct c" /listShort="S1550, S1549, yycN, yycO, yycP" /listLong="yycQ" /label="upshifts" promotor_-35 complement(3641406..3641411) /Source="Nicolas_upshift_promotors" /id="U3175" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1127 /SigmaFactorBS="aggcctcatacatgccttcaaacagaaaaaaGTAATAtttca gcatgtcagACGTAGCATTCATATGAGAaggctcctcatgctgaaagccctgtcctct c" /listShort="S1550, S1549, yycN, yycO, yycP" /listLong="yycQ" /label="promotor_-35" promotor_-35 3641966..3641974 /Source="Nicolas_upshift_promotors" /id="U3176" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=523 /SigmaFactorBS="acaggccttatcttattaccaagacgtGAAGGAAAAattgac tgctgAGCCGAATAGAATATGTGAggcaaaaatagacattttatatgccatttatgca g" /listShort="phrG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3641986..3642004 /Source="Nicolas_upshift_promotors" /id="U3176" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=523 /SigmaFactorBS="acaggccttatcttattaccaagacgtGAAGGAAAAattgac tgctgAGCCGAATAGAATATGTGAggcaaaaatagacattttatatgccatttatgca g" /listShort="phrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3641999 /Source="Nicolas_upshifts" /id="U3176" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=523 /SigmaFactorBS="acaggccttatcttattaccaagacgtGAAGGAAAAattgac tgctgAGCCGAATAGAATATGTGAggcaaaaatagacattttatatgccatttatgca g" /listShort="phrG" /GFF_Attribute="listLong" /label="upshifts" CDS 3642243..3642359 /gene="phrG" /locus_tag="BSU_40310" /old_locus_tag="BSU40310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12950930, 16553878, 16816200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12950930, 16553878, 16816200; Product type r: regulator" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapG" /protein_id="NP_391911.1" /db_xref="EnsemblGenomes-Gn:BSU40310" /db_xref="EnsemblGenomes-Tr:CAB16068" /db_xref="InterPro:IPR030968" /db_xref="SubtiList:BG11465" /db_xref="UniProtKB/Swiss-Prot:O32295" /translation="MKRFLIGAGVAAVILSGWFIADHQTHSQEMKVAEKMIG*" /label="phrG CDS" gene 3642243..3642359 /gene="phrG" /locus_tag="BSU_40310" /old_locus_tag="BSU40310" /label="phrG gene" downshifts 3642348 /Source="Nicolas_upshifts" /id="D2085" /incds=0 /nref=39 /ntot=249 /MaxReadThrough="4.8963" /MaxDrop="7.30713" /score="31.0184314" /energy="-13.7" /TU="U3173,U3176" /idTUdmin="U3173" /TUdmin="-45" /isTUend="FALSE" /label="downshifts" CDS complement(3642596..3643486) /gene="argI" /locus_tag="BSU_40320" /old_locus_tag="BSU40320" /EC_number="3.5.3.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:104957, 4216455, 7540694, 10931887, 11418582, 12533460, 22720735, 23625224, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 104957, 4216455, 7540694, 10931887, 11418582, 12533460, 22720735, 23625224, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginase" /protein_id="NP_391912.1" /db_xref="EnsemblGenomes-Gn:BSU40320" /db_xref="EnsemblGenomes-Tr:CAB16069" /db_xref="GOA:P39138" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR014033" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="SubtiList:BG10932" /db_xref="UniProtKB/Swiss-Prot:P39138" /translation="MDKTISVIGMPMDLGQARRGVDMGPSAIRYAHLIERLSDMGYTV EDLGDIPINREKIKNDEELKNLNSVLAGNEKLAQKVNKVIEEKKFPLVLGGDHSIAIG TLAGTAKHYDNLGVIWYDAHGDLNTLETSPSGNIHGMPLAVSLGIGHESLVNLEGYAP KIKPENVVIIGARSLDEGERKYIKESGMKVYTMHEIDRLGMTKVIEETLDYLSACDGV HLSLDLDGLDPNDAPGVGTPVVGGISYRESHLAMEMLYDAGIITSAEFVEVNPILDHK NKTGKTAVELVESLLGKKLL*" /label="argI CDS" gene complement(3642596..3643486) /gene="argI" /locus_tag="BSU_40320" /old_locus_tag="BSU40320" /label="argI gene" downshifts complement(3642602) /Source="Nicolas_upshifts" /id="D2086" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="3.33097" /MaxDrop="3.38667" /score="2.36475602" /energy="-13.7" /TU="U3177" /idTUdmin="U3177" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" downshifts complement(3642664) /Source="Nicolas_upshifts" /id="D2087" /incds=1 /nref=28 /ntot=201 /MaxReadThrough="5.16507" /MaxDrop="5.79932" /score="2.36475602" /energy="-13.7" /TU="U3177" /idTUdmin="U3177" /TUdmin="-151" /isTUend="FALSE" /label="downshifts" CDS complement(3643560..3644963) /gene="rocE" /locus_tag="BSU_40330" /old_locus_tag="BSU40330" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7540694, 10648515, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7540694, 10648515, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="arginine/ornithine/gamma-aminobutyrate permease" /protein_id="NP_391913.1" /db_xref="EnsemblGenomes-Gn:BSU40330" /db_xref="EnsemblGenomes-Tr:CAB16070" /db_xref="GOA:P39137" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG10933" /db_xref="UniProtKB/Swiss-Prot:P39137" /translation="MNTNQDNGNQLQRTMKSRHLFMISLGGVIGTGFFLGTGFTINQA GPLGAVLSYLVGGFIMFLTMLCLGELAVAFPVSGSFQTYATKFISPAFGFAFGWLYWL GWAVTCAIEFLSAGQLMQRWFPHIDVWIWCLVFAALMFILNAITTKAFAESEFWFSGI KILIILLFIILGGAAMFGLIDLKGGEQAPFLTHFYEDGLFPNGIKAMLITMITVNFAF QGTELIGVAAGESEDPEKTIPRSIKQTVWRTLVFFVLSIIVIAGMIPWKQAGVVESPF VAVFEQIGIPYAADIMNFVILIALLSVANSGLYASTRILYAMANEGQAFKALGKTNQR GVPMYSLIVTMAVACLSLLTKFAQAETVYMVLLSLAGMSAQVGWITISLSQIMFRRKY IREGGKIEDLKFKTPLYPVLPLIGLTLNTVVLISLAFDPEQRIALYCGVPFMIICYII YHVVIKKRQQANRQLEL*" /label="rocE CDS" gene complement(3643560..3644963) /gene="rocE" /locus_tag="BSU_40330" /old_locus_tag="BSU40330" /label="rocE gene" S_feature complement(3644964..3645185) /Source="Nicolas_S_feature" /locus_tag="new_4144079_4144300_c" /HighExp="Lbstat, S0, LPh, T1.30H, HPh, T2.0H, LPhT, BI, M0t90, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.884" /TUlongSig="NA" /TUlongPSig="NA" /label="S1551" CDS complement(3645186..3646391) /gene="rocD" /locus_tag="BSU_40340" /old_locus_tag="BSU40340" /EC_number="2.6.1.13" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7540694, 9383188, 22720735, 23869754" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7540694, 9383188, 22720735, 23869754; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ornithine aminotransferase" /protein_id="NP_391914.1" /db_xref="EnsemblGenomes-Gn:BSU40340" /db_xref="EnsemblGenomes-Tr:CAB16071" /db_xref="GOA:P38021" /db_xref="InterPro:IPR004636" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR010164" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR034757" /db_xref="SubtiList:BG10722" /db_xref="UniProtKB/Swiss-Prot:P38021" /translation="MTALSKSKEIIDQTSHYGANNYHPLPIVISEALGAWVKDPEGNE YMDMLSAYSAVNQGHRHPKIIQALKDQADKITLTSRAFHNDQLGPFYEKTAKLTGKEM ILPMNTGAEAVESAVKAARRWAYEVKGVADNQAEIIACVGNFHGRTMLAVSLSSEEEY KRGFGPMLPGIKLIPYGDVEALRQAITPNTAAFLFEPIQGEAGIVIPPEGFLQEAAAI CKEENVLFIADEIQTGLGRTGKTFACDWDGIVPDMYILGKALGGGVFPISCIAADREI LGVFNPGSHGSTFGGNPLACAVSIASLEVLEDEKLADRSLELGEYFKSELESIDSPVI KEVRGRGLFIGVELTEAARPYCERLKEEGLLCKETHDTVIRFAPPLIISKEDLDWAIE KIKHVLRNA*" /label="rocD CDS" gene complement(3645186..3646391) /gene="rocD" /locus_tag="BSU_40340" /old_locus_tag="BSU40340" /label="rocD gene" misc_feature complement(3646448..3646466) /Source="Nicolas_upshift_promotors" /id="U3177" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.884115884115884" /psig="0.884115884115884" /xcortree=390 /SigmaFactorBS="gcaccttgtcctcgaaaattgtagaaaacacacgaattcttg attTGGCACAGAACTTGCATTTatataaagggaaagcaggataacatgttgaaacaga a" /listShort="rocD, S1551, rocE, argI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3646451) /Source="Nicolas_upshifts" /id="U3177" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.884115884115884" /psig="0.884115884115884" /xcortree=390 /SigmaFactorBS="gcaccttgtcctcgaaaattgtagaaaacacacgaattcttg attTGGCACAGAACTTGCATTTatataaagggaaagcaggataacatgttgaaacaga a" /listShort="rocD, S1551, rocE, argI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3646561..3646566 /Source="Nicolas_upshift_promotors" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3646581..3646600 /Source="Nicolas_upshift_promotors" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3646596 /Source="Nicolas_upshifts" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="upshifts" CDS 3646632..3648017 /gene="rocR" /locus_tag="BSU_40350" /old_locus_tag="BSU40350" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9194709, 12533460, 12634342, 23869754" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9194709, 12533460, 12634342, 23869754; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (NtrC/NifA family)" /protein_id="NP_391915.1" /db_xref="EnsemblGenomes-Gn:BSU40350" /db_xref="EnsemblGenomes-Tr:CAB16072" /db_xref="GOA:P38022" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025662" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR035965" /db_xref="SubtiList:BG10723" /db_xref="UniProtKB/Swiss-Prot:P38022" /translation="MVKDSEFLTLVFQSILDEIDVGLHVVDEHGNTIVYNNKMMQIED MEKHDVLNKNLMDVFMFSKQQDSTLVQALQEGKTIKNVKQSYFNNKGQEITTINHTYP IVQDGKIRGAVEIAKDVTKLERLIRENMNKKGSTTYTFDSILGTSPAIQDVIENAKRA TRTSSSVLLAGETGTGKELFAQSIHNGSDRSGGPFISQNCAALPDSLVESILFGTKKG AFTGAVDQPGLFEQAHGGTLLLDEINSLNLSLQAKLLRALQERKIRRIGSTKDTPIDV RIIATMNEDPIDAIAGERMRKDLYYRLSVVTLIIPPLRERKEDILLLASEFIQKNNHL FQMNVEHISDDVKQFFLSYDWPGNIRELEHMIEGAMNFMTDEQTITASHLPYQYRMKI KPADIPEPETPRHQPAADLKEKMESFEKYVIENVLRKHGHNISKAAQELGISRQSLQY RLKKFSHSSNE*" /label="rocR CDS" gene 3646632..3648017 /gene="rocR" /locus_tag="BSU_40350" /old_locus_tag="BSU40350" /label="rocR gene" CDS complement(3647999..3648187) /gene="yyzO" /locus_tag="BSU_40359" /old_locus_tag="BSU40359" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17198402; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="fragment of putative sensor protein" /db_xref="PSEUDO:CAX52717.1" /translation="MFDRFYKADPSRSRKYGGSGLGLAITKSIIDNHNGTIEVKSEIG RGTVFLIRLPAPDYSLDE*" /label="yyzO CDS" gene complement(3647999..3648187) /gene="yyzO" /locus_tag="BSU_40359" /old_locus_tag="BSU40359" /pseudo /label="yyzO gene" CDS complement(3648304..3648432) /locus_tag="BSU_40358" /old_locus_tag="BSU40358" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514013.1" /translation="MPGCFDMQKKLNRGHARSVEKGYIEYEEKYKMDVTRETANGS*" /label="hypothetical protein CDS" gene complement(3648304..3648432) /locus_tag="BSU_40358" /old_locus_tag="BSU40358" /label="gene" downshifts 3648356 /Source="Nicolas_upshifts" /id="D2088" /incds=0 /nref=1 /ntot=146 /MaxReadThrough="0.86899" /MaxDrop="2.90385" /score="20.2816165" /energy="-10.8" /TU="NA" /idTUdmin="U3178" /TUdmin=110 /isTUend="FALSE" /label="downshifts" CDS complement(3648452..3649654) /gene="htrC" /locus_tag="BSU_40360" /old_locus_tag="BSU40360" /EC_number="3.4.21.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10692364, 11133960, 16030236, 25384476" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10692364, 11133960, 16030236, 25384476; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation membrane serine protease" /protein_id="NP_391916.1" /db_xref="EnsemblGenomes-Gn:BSU40360" /db_xref="EnsemblGenomes-Tr:CAB16073" /db_xref="GOA:P39668" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG11054" /db_xref="UniProtKB/Swiss-Prot:P39668" /translation="MVDYEREEEHTTPEQPKRSKKGYFLSSLIGVIVGAVLMAFIMPY LSNEGLDTGALDQQQNNNGRESIRTVNVSVNNAVTKIVSNMSPAVVGVVNIQKSDIWG ESGEAGSGSGVIYKKNDHSAYVVTNHHVIEGASQIEISLKDGSRVSADLVGSDQLMDL AVLRVKSDKIKAVADFGNSDKVKSGEPVIAIGNPLGLEFAGSVTQGVISGTERAIPVD SNGDGQPDWNAEVLQTDAAINPGNSGGALLNMDGKVIGINSMKIAESAVEGIGLSIPS KLVIPVIEDLERYGKVKRPFLGIEMKSLSDIASYHWDETLKLPKNVTNGAVVMGVDAF SPAGKAGLKELDVITEFDGYKVNDIVDLRKRLYQKKVGDRVKVKFYRGGKEKSVDIKL SSADQLGS*" /label="htrC CDS" gene complement(3648452..3649654) /gene="htrC" /locus_tag="BSU_40360" /old_locus_tag="BSU40360" /label="htrC gene" downshifts complement(3648476) /Source="Nicolas_upshifts" /id="D2089" /incds=0 /nref=134 /ntot=253 /MaxReadThrough="2.3073" /MaxDrop="5.06813" /score="5.6507537" /energy="-15" /TU="NA" /idTUdmin="U3179" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3649686..3649697) /Source="Nicolas_upshift_promotors" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3649686) /Source="Nicolas_upshifts" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3649712..3649718) /Source="Nicolas_upshift_promotors" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3649736..3650530) /gene="walJ" /locus_tag="BSU_40370" /old_locus_tag="BSU40370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9829949, 16030236, 21169496; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391917.2" /db_xref="EnsemblGenomes-Gn:BSU40370" /db_xref="EnsemblGenomes-Tr:CAB16074" /db_xref="GOA:C0SP91" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11464" /db_xref="UniProtKB/Swiss-Prot:C0SP91" /translation="MSLQFSVLASGSTGNAFYLETEDHAFLVDAGLSGKAMDGLMAQI GRKLDDVDGIFVTHEHSDHIKGLGVVARKYKLPIYANEKTWKAMENQIGKIDTDQKFV FPMETVKSFGGLDVESFGVSHDAAEPMFYVFHYSGRKLALMTDTGYVSDRMKGIIRSA NVFVFESNHDVGMLQMGRYPWSIKRRILSDVGHVSNEDAALAMTDVIGDETSRIYLAH LSQDNNMKELARMSVQQTLASKGFVTGETFDLYDTDPKKATPLCAV*" /label="walJ CDS" gene complement(3649736..3650530) /gene="walJ" /locus_tag="BSU_40370" /old_locus_tag="BSU40370" /label="walJ gene" CDS complement(3650552..3651394) /gene="walI" /locus_tag="BSU_40380" /old_locus_tag="BSU40380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16030236, 17307848, 17307850, 18408157, 21219466" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16030236, 17307848, 17307850, 18408157, 21219466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of WalRK" /protein_id="NP_391918.1" /db_xref="EnsemblGenomes-Gn:BSU40380" /db_xref="EnsemblGenomes-Tr:CAB16075" /db_xref="GOA:Q45612" /db_xref="InterPro:IPR018604" /db_xref="PDB:2O3O" /db_xref="SubtiList:BG11463" /db_xref="UniProtKB/Swiss-Prot:Q45612" /translation="MEWNKTKSIFIVAFLILDIFLGYQFFQKWQATGKEYEVIKNDVE HDMKADHITYEGLNKEATEGYRITANQKSFSKEEIEALKDQKPLMDMPSDDHKVTSLK MKFANPIALSKKDIEDDAQALVSSKIQDGEKYKLWKVDKSKKEIIFFQTYEGHYIYQK TDNPSNMIGQVVLHLNGKNEVVSYDQTTLETFKQIQKESLITEMDAVELLYYQNQLKE YSTVKSCKFGYVAQYPLTSTQVLAPVWRITVEYEKKVNGEKKTVQEYFTVNALESTIL DTDQ*" /label="walI CDS" gene complement(3650552..3651394) /gene="walI" /locus_tag="BSU_40380" /old_locus_tag="BSU40380" /label="walI gene" CDS complement(3651381..3652748) /gene="walH" /locus_tag="Delta6_BSU_40390_SNPvariant" /old_locus_tag="BSU_40390" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16030236, 16600972, 17307850, 26999783" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16030236, 16600972, 17307850, 26999783; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of WalRK(YycFG)" /protein_id="NP_391919.1" /db_xref="EnsemblGenomes-Gn:BSU40390" /db_xref="EnsemblGenomes-Tr:CAB16076" /db_xref="GOA:Q794W0" /db_xref="InterPro:IPR009996" /db_xref="PDB:2FGT" /db_xref="SubtiList:BG11462" /db_xref="UniProtKB/Swiss-Prot:Q794W0" /modified_by="User" /translation="MKRENIKTILLTVLVVISLVFTWGIWTFQPNFSEGSSSTESTVR VKHKIEKTTQKLSETVRPRDMFIHDDGAHYKVDDNALYEEIWSDLPHWDVKGIKDISD QYDKAGFKSWFYGIGGSEAKLDLQFSDTIPIDIFQTLFKWSNQSFEYSSFDHILIPFN ETKANKKIYLVSYSKQLILEVTVESANYRNIMNDLKNRQSNMPAFSLFSIGSKKEFLL PNKPLTMDKKEFVTESIKTNTFKQALFSDPSIVREDSNYTNRNVLTDGISRLDVNLSQ RQVQFQQRNLVQSTSYQTGELIKKSQKYLEDTGSWTDHYQFFNINDSQQLSFYIFMDQ IPVINSTAKPFGATSAITVQWANDDILSYKRPNYSLGTNPIKTSETELMGGSEVKMLL SKQTAYDTDKIDQIFLAYQLVSTSTNDDPLVELEPVWAMKVNGKIVPITKDLLRKEGA NSGVE*" /label="Delta6_BSU_40390_SNPvariant" gene complement(3651381..3652748) /gene="walH" /locus_tag="Delta6_BSU_40390_SNPvariant" /old_locus_tag="BSU_40390" /modified_by="User" /label="Delta6_BSU_40390_SNPvariant" Polymorphism join(3651975,3651977) /Source="geneious" /ID="SNP_BsDelta6_4151091_4151091" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change="N -> T" /CDS_Position=773 /Change="T -> G" /Codon_Change="AAC -> ACC" /Coverage=184 /locus_tag="BSU_40390" /Protein_Effect="Substitution" /Reference_Frequency="0.5%" /Reference_Nucleotides="T" /Variant_Nucleotides="G" /Variant_P_Value=0 /Variant_Raw_Frequency=183 /comment="Delta6_BSU_40390_SNPvariant" /modified_by="User" / /label="Polymorphism_Delta6" CDS complement(3652738..3654573) /gene="walK" /locus_tag="BSU_40400" /old_locus_tag="BSU40400" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 19019149, 22751669" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 19019149, 22751669; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YycG]" /protein_id="NP_391920.1" /db_xref="EnsemblGenomes-Gn:BSU40400" /db_xref="EnsemblGenomes-Tr:CAB16077" /db_xref="GOA:Q45614" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:3SL2" /db_xref="SubtiList:BG11461" /db_xref="UniProtKB/Swiss-Prot:Q45614" /translation="MNKVGFFRSIQFKITLIYVLLIIIAMQIIGVYFVNQVEKSLISS YEQSLNQRIDNLSYYIEQEYKSDNDSTVIKDDVSRILNDFTKSDEVREISFVDKSYEV VGSSKPYGEEVAGKQTTDLIFKRIFSTKQSYLRKYYDPKSKIRVLISAKPVMTENQEV VGAIYVVASMEDVFNQMKTINTILASGTGLALVLTALLGIFLARTITHPLSDMRKQAM ELAKGNFSRKVKKYGHDEIGQLATTFNHLTRELEDAQAMTEGERRKLASVIAYMTDGV IATNRNGAIILLNSPALELLNVSRETALEMPITSLLGLQENYTFEDLVEQQDSMLLEI ERDDELTVLRVNFSVIQREHGKIDGLIAVIYDVTEQEKMDQERREFVANVSHELRTPL TTMRSYLEALAEGAWENKDIAPRFLMVTQNETERMIRLVNDLLQLSKFDSKDYQFNRE WIQIVRFMSLIIDRFEMTKEQHVEFIRNLPDRDLYVEIDQDKITQVLDNIISNALKYS PEGGHVTFSIDVNEEEELLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTRKLGGTGL GLAIAKEMVQAHGGDIWADSIEGKGTTITFTLPYKEEQEDDWDEA*" /label="walK CDS" gene complement(3652738..3654573) /gene="walK" /locus_tag="BSU_40400" /old_locus_tag="BSU40400" /label="walK gene" CDS complement(3654581..3655288) /gene="walR" /locus_tag="BSU_40410" /old_locus_tag="BSU40410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 18789936, 19019149, 21219466, 23199363, 24125693, 26102633, 28674376" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 18789936, 19019149, 21219466, 23199363, 24125693, 26102633, 28674376; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YycF]" /protein_id="NP_391921.1" /db_xref="EnsemblGenomes-Gn:BSU40410" /db_xref="EnsemblGenomes-Tr:CAB16078" /db_xref="GOA:P37478" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:2D1V" /db_xref="PDB:2ZWM" /db_xref="PDB:3F6P" /db_xref="SubtiList:BG10001" /db_xref="UniProtKB/Swiss-Prot:P37478" /translation="MDKKILVVDDEKPIADILEFNLRKEGYEVHCAHDGNEAVEMVEE LQPDLILLDIMLPNKDGVEVCREVRKKYDMPIIMLTAKDSEIDKVIGLEIGADDYVTK PFSTRELLARVKANLRRQLTTAPAEEEPSSNEIHIGSLVIFPDAYVVSKRDETIELTH REFELLHYLAKHIGQVMTREHLLQTVWGYDYFGDVRTVDVTVRRLREKIEDNPSHPNW IVTRRGVGYYLRNPEQD*" /label="walR CDS" gene complement(3654581..3655288) /gene="walR" /locus_tag="BSU_40410" /old_locus_tag="BSU40410" /label="walR gene" S_feature complement(3655289..3655385) /Source="Nicolas_S_feature" /locus_tag="new_4154404_4154500_c" /HighExp="H2O2, G180, G150, Paraq, G135, Oxctl, dia0, LBGstat, dia5, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-" /TUshortPSig="1, 1, 0.11" /TUlongSig="SigA" /TUlongPSig="0.986" /label="S1552" promotor_-10 complement(3655373..3655392) /Source="Nicolas_upshift_promotors" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3655385) /Source="Nicolas_upshifts" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3655387..3655579) /Source="Nicolas_S_feature" /locus_tag="new_4154502_4154694_c" /HighExp="G180, Paraq, Oxctl, G135, G150, H2O2, T0.30H, BMM, Cold, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-" /TUshortPSig="0.986, 1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1553" promotor_-35 complement(3655408..3655411) /Source="Nicolas_upshift_promotors" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3655579) /Source="Nicolas_upshifts" /id="U3181" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig="0.986013986013986" /xcortree=2753 /SigmaFactorBS="tttttcttttaggaaaaaggcaaacatgaggAGTGTTATAAT AGAAGAAAAagggagaaccggccctgcggccggttcaaagaagaagacgtcattgata a" /listShort="S1553" /listLong="S1552, walR, walK, walH, yycI, yycJ, htrC" /label="upshifts" misc_feature complement(3655589..3655608) /Source="Nicolas_upshift_promotors" /id="U3181" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig="0.986013986013986" /xcortree=2753 /SigmaFactorBS="tttttcttttaggaaaaaggcaaacatgaggAGTGTTATAAT AGAAGAAAAagggagaaccggccctgcggccggttcaaagaagaagacgtcattgata a" /listShort="S1553" /listLong="S1552, walR, walK, walH, yycI, yycJ, htrC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(3655671) /Source="Nicolas_upshifts" /id="D2090" /incds=0 /nref=8 /ntot=83 /MaxReadThrough="5.21091" /MaxDrop="5.81799" /score="24.1725164" /energy="-10.6" /TU="U3183,U3184" /idTUdmin="U3181" /TUdmin="-264" /isTUend="FALSE" /label="downshifts" tRNA complement(3655672..3655744) /gene="trnY-Phe" /locus_tag="BSU_tRNA_1" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Phe tRNA" gene complement(3655672..3655744) /gene="trnY-Phe" /locus_tag="BSU_tRNA_1" /label="trnY-Phe gene" tRNA complement(3655780..3655856) /gene="trnY-Asp" /locus_tag="BSU_tRNA_2" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Asp tRNA" gene complement(3655780..3655856) /gene="trnY-Asp" /locus_tag="BSU_tRNA_2" /label="trnY-Asp gene" S_feature complement(3655857..3655937) /Source="Nicolas_S_feature" /locus_tag="new_4154972_4155052_c" /HighExp="Oxctl, Heat, BMM, Paraq, UNK1, H2O2, C30, MG 45, G180, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1554" tRNA complement(3655938..3656009) /gene="trnY-Glu" /locus_tag="BSU_tRNA_3" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Glu tRNA" gene complement(3655938..3656009) /gene="trnY-Glu" /locus_tag="BSU_tRNA_3" /label="trnY-Glu gene" tRNA complement(3656019..3656094) /gene="trnY-Lys" /locus_tag="BSU_tRNA_4" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Lys tRNA" gene complement(3656019..3656094) /gene="trnY-Lys" /locus_tag="BSU_tRNA_4" /label="trnY-Lys gene" misc_feature 3656066..3656082 /Source="Nicolas_upshift_promotors" /id="U3182" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.652347652347652" /psig="0.0739260739260739" /xcortree=1705 /SigmaFactorBS="tggtgagccatgaaggactcgaaccttcgaccctctgattaa aagtcAGATGCTCTACCAACTGagctaatggctcttaaagatgtcggaatttctatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3656079 /Source="Nicolas_upshifts" /id="U3182" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.652347652347652" /psig="0.0739260739260739" /xcortree=1705 /SigmaFactorBS="tggtgagccatgaaggactcgaaccttcgaccctctgattaa aagtcAGATGCTCTACCAACTGagctaatggctcttaaagatgtcggaatttctatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3656095..3656191) /Source="Nicolas_S_feature" /locus_tag="new_4155210_4155306_c" /HighExp="LBGstat, C30, UNK1, Oxctl, HPh, Heat, MG 150, BMM, Paraq, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1555" promotor_-10 complement(3656175..3656194) /Source="Nicolas_upshift_promotors" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3656191) /Source="Nicolas_upshifts" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3656208..3656215) /Source="Nicolas_upshift_promotors" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box complement(3656225..3656326) /Source="Nicolas_upshift_promotors" /id="U3184" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.587412587412587" /psig="0.10989010989011" /xcortree=285 /SigmaFactorBS="cgaactaaatagaatatgtctgcaagcccctatttaaggggc ttgtttttgtttgaaagccgcatataagttggtctgagaaaaaaatatgaaaaaaaac c" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3656265) /Source="Nicolas_upshifts" /id="U3184" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.587412587412587" /psig="0.10989010989011" /xcortree=285 /SigmaFactorBS="cgaactaaatagaatatgtctgcaagcccctatttaaggggc ttgtttttgtttgaaagccgcatataagttggtctgagaaaaaaatatgaaaaaaaac c" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3656319..3657611) /gene="purA" /locus_tag="BSU_40420" /old_locus_tag="BSU40420" /EC_number="6.3.4.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1312531, 10368157, 16163456, 21424839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1312531, 10368157, 16163456, 21424839; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylosuccinate synthetase" /protein_id="NP_391922.1" /db_xref="EnsemblGenomes-Gn:BSU40420" /db_xref="EnsemblGenomes-Tr:CAB16079" /db_xref="GOA:P29726" /db_xref="InterPro:IPR001114" /db_xref="InterPro:IPR018220" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033128" /db_xref="SubtiList:BG10002" /db_xref="UniProtKB/Swiss-Prot:P29726" /translation="MSSVVVVGTQWGDEGKGKITDFLSENAEVIARYQGGNNAGHTIK FDGITYKLHLIPSGIFYKDKTCVIGNGMVVDPKALVTELAYLHERNVSTDNLRISNRA HVILPYHLKLDEVEEERKGANKIGTTKKGIGPAYMDKAARIGIRIADLLDRDAFAEKL ERNLEEKNRLLEKMYETEGFKLEDILDEYYEYGQQIKKYVCDTSVVLNDALDEGRRVL FEGAQGVMLDIDQGTYPFVTSSNPVAGGVTIGSGVGPTKIKHVVGVSKAYTTRVGDGP FPTELKDEIGDQIREVGREYGTTTGRPRRVGWFDSVVVRHARRVSGITDLSLNSIDVL AGIETLKICVAYRYKGEIIEEFPASLKALAECEPVYEEMPGWTEDITGAKSLSELPEN ARHYLERVSQLTGIPLSIFSVGPDRSQTNVLRSVYRAN*" /label="purA CDS" gene complement(3656319..3657611) /gene="purA" /locus_tag="BSU_40420" /old_locus_tag="BSU40420" /label="purA gene" downshifts complement(3656330) /Source="Nicolas_upshifts" /id="D2091" /incds=0 /nref=200 /ntot=241 /MaxReadThrough="2.03104" /MaxDrop="6.53551" /score="13.9967927" /energy="-10.5" /TU="NA" /idTUdmin="U3185" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3657651..3657670) /Source="Nicolas_upshift_promotors" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3657671) /Source="Nicolas_upshifts" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3657685..3657692) /Source="Nicolas_upshift_promotors" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3657817..3658236) /gene="yycE" /locus_tag="BSU_40430" /old_locus_tag="BSU40430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16731985" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391923.1" /db_xref="EnsemblGenomes-Gn:BSU40430" /db_xref="EnsemblGenomes-Tr:CAB16080" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="PDB:1TWU" /db_xref="SubtiList:BG10003" /db_xref="UniProtKB/Swiss-Prot:P37479" /translation="MGKRFSSFQAAQIRIARPTGQLDEIIRFYEEGLCLKRIGEFSQH NGYDGVMFGLPHADYHLEFTQYEGGSTAPVPHPDSLLVFYVPNAVELAAITSKLKHMG YQEVESENPYWSNGGVTIEDPDGWRIVFMNSKGISGK*" /label="yycE CDS" gene complement(3657817..3658236) /gene="yycE" /locus_tag="BSU_40430" /old_locus_tag="BSU40430" /label="yycE gene" promotor_-10 complement(3658234..3658245) /Source="Nicolas_upshift_promotors" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3658245) /Source="Nicolas_upshifts" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3658260..3658266) /Source="Nicolas_upshift_promotors" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3658357..3659721) /gene="dnaC" /locus_tag="BSU_40440" /old_locus_tag="BSU40440" /EC_number="3.6.4.12" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7711902, 10844689, 12682299, 12718886, 16002087, 19744498, 23563155, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7711902, 10844689, 12682299, 12718886, 16002087, 19744498, 23563155, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="replicative DNA helicase" /protein_id="NP_391924.2" /db_xref="EnsemblGenomes-Gn:BSU40440" /db_xref="EnsemblGenomes-Tr:CAB16081" /db_xref="GOA:P37469" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR007692" /db_xref="InterPro:IPR007693" /db_xref="InterPro:IPR007694" /db_xref="InterPro:IPR016136" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036185" /db_xref="SubtiList:BG10004" /db_xref="UniProtKB/Swiss-Prot:P37469" /translation="MTDLLNDRLPPQNIEAEQAVLGAIFLQPSALTLASEVLIPDDFY RMSHQKIYNAMLVLGDRGEPVDLVTVTSELANTDLLEEVGGISYLTDIANSVPTAANI EYYAKIVEEKSILRRLIRTATTIAQDGYTREDEVEDLLSEAEKTIMEVAQRKNTSAFQ NIKDVLVQTYDNIEQLHNRKGDITGIPTGFTELDRMTAGFQRNDLIIVAARPSVGKTA FALNIAQNVATKTDESVAIFSLEMGAEQLVMRMLCAEGNINAQNLRTGNLTEEDWGKL TMAMGSLSNSGIYIDDTPGIRVSEIRAKCRRLKQESGLGMILIDYLQLIQGSGRSKDN RQQEVSEISRELKSIARELQVPVIALSQLSRGVEQRQDKRPMMSDIRESGSIEQDADI VAFLYRDDYYDKETENKNIIEIIIAKQRNGPVGTVSLAFVKEYNKFVNLERRFDDAGV PPGA*" /label="dnaC CDS" gene complement(3658357..3659721) /gene="dnaC" /locus_tag="BSU_40440" /old_locus_tag="BSU40440" /label="dnaC gene" downshifts complement(3658377) /Source="Nicolas_upshifts" /id="D2092" /incds=0 /nref=3 /ntot=107 /MaxReadThrough="1.37092" /MaxDrop="3.96365" /score="31.6981667" /energy="-12.6" /TU="NA" /idTUdmin="U3187" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3658421) /Source="Nicolas_upshifts" /id="D2093" /incds=1 /nref=9 /ntot=190 /MaxReadThrough="3.89737" /MaxDrop="3.21735" /score="31.6981667" /energy="-12.6" /TU="U3187" /idTUdmin="U3190" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3659752..3659771) /Source="Nicolas_upshift_promotors" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3659766) /Source="Nicolas_upshifts" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3659786..3659788) /Source="Nicolas_upshift_promotors" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3659833..3659839 /Source="Nicolas_upshift_promotors" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="promotor_-35" promotor_-10 3659854..3659872 /Source="Nicolas_upshift_promotors" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="promotor_-10" upshifts 3659856 /Source="Nicolas_upshifts" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="upshifts" CDS 3659891..3660091 /gene="yycD" /locus_tag="BSU_40450" /old_locus_tag="BSU40450" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717295" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391925.1" /db_xref="EnsemblGenomes-Gn:BSU40450" /db_xref="EnsemblGenomes-Tr:CAB16082" /db_xref="InterPro:IPR018691" /db_xref="InterPro:IPR020086" /db_xref="SubtiList:BG10005" /db_xref="UniProtKB/Swiss-Prot:P37480" /translation="MIKKYAITPNVDADGWFIEVENVAPTALYTSKDAAIEKAKQVAK ENSPSKLVIYDQFKNVEEEHSF*" /label="yycD CDS" gene 3659891..3660091 /gene="yycD" /locus_tag="BSU_40450" /old_locus_tag="BSU40450" /label="yycD gene" downshifts 3660061 /Source="Nicolas_upshifts" /id="D2094" /incds=0 /nref=15 /ntot=43 /MaxReadThrough="4.45045" /MaxDrop="5.68737" /score="12.3008592" /energy="-9.5" /TU="U3188" /idTUdmin="U3188" /TUdmin="-352" /isTUend="FALSE" /label="downshifts" S_feature 3660106..3660427 /Source="Nicolas_S_feature" /locus_tag="new_4159220_4159541" /HighExp="Etha, C30, Salt, S6, S8, M9-stat, S7, Oxctl, Paraq, Heat" /AntisenseName="yyzB" /AntisenseCor="0.309580857935493" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1556" CDS complement(3660139..3660342) /gene="yyzB" /locus_tag="BSU_40460" /old_locus_tag="BSU40460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391926.1" /db_xref="EnsemblGenomes-Gn:BSU40460" /db_xref="EnsemblGenomes-Tr:CAB16083" /db_xref="SubtiList:BG14171" /db_xref="UniProtKB/Swiss-Prot:O32296" /translation="MHAPLSLLKQMLKEHQIDTEKAVTFEEYIAMRLKLQELMGKFAS IGEWDLYQKAADLMMHIGIQWMK*" /label="yyzB CDS" gene complement(3660139..3660342) /gene="yyzB" /locus_tag="BSU_40460" /old_locus_tag="BSU40460" /label="yyzB gene" S_feature complement(3660343..3660643) /Source="Nicolas_S_feature" /locus_tag="new_4159457_4159757_c" /HighExp="S6, S8, S7, S5, S4, BT, B36, T5.0H, S3, C30" /AntisenseName="yycC" /AntisenseCor="-0.77379453158709499" /AntisenseRegPval="-54.1" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.049" /TUlongSig="NA" /TUlongPSig="NA" /label="S1557" promotor_-35 3660408..3660411 /Source="Nicolas_upshift_promotors" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3660426..3660445 /Source="Nicolas_upshift_promotors" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3660429 /Source="Nicolas_upshifts" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="upshifts" CDS 3660463..3660603 /gene="yycC" /locus_tag="BSU_40470" /old_locus_tag="BSU40470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28546427" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391927.1" /db_xref="EnsemblGenomes-Gn:BSU40470" /db_xref="EnsemblGenomes-Tr:CAB16084" /db_xref="InterPro:IPR025550" /db_xref="SubtiList:BG10006" /db_xref="UniProtKB/Swiss-Prot:P37481" /translation="MRPLQISAETAQKLAESLNLPLEQIMHMPQHILLAKMAELQKED KS*" /label="yycC CDS" gene 3660463..3660603 /gene="yycC" /locus_tag="BSU_40470" /old_locus_tag="BSU40470" /label="yycC gene" S_feature 3660604..3660675 /Source="Nicolas_S_feature" /locus_tag="new_4159718_4159789" /HighExp="Sw, LoTm, Gly, BC, HiOs, B60, S0, T-5.40H, LBGstat, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigB" /TUlongPSig=1 /label="S1558" upshifts complement(3660651) /Source="Nicolas_upshifts" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3660654..3660668) /Source="Nicolas_upshift_promotors" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3660676..3660680) /Source="Nicolas_upshift_promotors" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3660676..3661884 /gene="yycB" /locus_tag="BSU_40480" /old_locus_tag="BSU40480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25790494; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative anion ABC transporter (permease)" /protein_id="NP_391928.1" /db_xref="EnsemblGenomes-Gn:BSU40480" /db_xref="EnsemblGenomes-Tr:CAB16085" /db_xref="GOA:P37482" /db_xref="InterPro:IPR004747" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10007" /db_xref="UniProtKB/Swiss-Prot:P37482" /translation="MPHPHNKKIQSFWLITGIIFIAFNLRPAITSVGPVISSIRAELH MSNGAAGFLTALPLLSFAVLSPLAPKLGQRLGNERTLWLGLVILLIGVLTRSTGYTAA LFFGTALIGVGIAIGNVLLPSLIKHKYPEKPGIMISLYTTSMNIFAALASGVSVPLAT QMNGGWKQAFLLWGGLALLALLIWIPQLRHRDTANQTMKLQSSSIWASKMAWYVTIFM GLQSFLFYSSIAWFPEILRSHGIDTATAGWMVSLMQFASLPSTFLTPVLADRVKQQRG IVAALASVYLIGLCGLLAGGSHTLLAIWMIIIGIGQGSSISLALTLIGLRSENAQQAA ALSGMSQSFGYLLAAVGPIFVGYLFDQTHSWTMPIVLLIAALIVMGAAGQGAGRDRYI FQSEKQRNSA*" /label="yycB CDS" gene 3660676..3661884 /gene="yycB" /locus_tag="BSU_40480" /old_locus_tag="BSU40480" /label="yycB gene" downshifts 3661865 /Source="Nicolas_upshifts" /id="D2095" /incds=0 /nref=148 /ntot=242 /MaxReadThrough="3.65611" /MaxDrop="4.91246" /score="26.443484" /energy="-10.1" /TU="U3189" /idTUdmin="U3189" /TUdmin="-484" /isTUend="FALSE" /label="downshifts" CDS 3661989..3664046 /gene="yycA" /locus_tag="BSU_40490" /old_locus_tag="BSU40490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyl transferase" /protein_id="NP_391929.2" /db_xref="EnsemblGenomes-Gn:BSU40490" /db_xref="EnsemblGenomes-Tr:CAB16086" /db_xref="GOA:P37483" /db_xref="SubtiList:BG10008" /db_xref="UniProtKB/Swiss-Prot:P37483" /translation="MKTKRFDAALILILLAAAFLNTYHIWQDDTANQYYLAAVKSMTQ SFHNFFYASFDPSGFVTVDKPPVVLWIQTIFALIFGVHTWSVIIPQALAGVGSVFLLY RMVKPTFGVGAARIAALVMALTPIAVAVSRTNNIDSMLVFTLLLGSTCLLRAVKQGKL VWLLTAFALIGLAFNMKMMQAFMVLPAFVLFYLIASRVSLKKKIGSLLLSLVLLTGLS LSWAIAVDSASSSSRPYVGSSQTNSVLELAFGYNGTERLFGQTTGLAKGDMNAAGGGN MQNQDNMQAPNGNGSSFSQNGNQSFGNHSQAPQPPNGQTGALNGGGGTPPTGGNGPGN GGPGGGGGKSVNMFGTGDPGPLRLFQSALSGQISWMLPFSLIGLLGAIISWYRDRRGH AAKMKETLFWAAWLVPVAGFFSIAGFFHQYYLIMLAPPIAALSGIGWYTMHRLYKNNK DWSSYLLPAAVLITAVFQVYILSAYTSQIGSVWMYVLGLLGLGITLALLMLKRSHPFS KLLTIISLCVLLLTPVYWSATPLLYGGNSVLPESGPQLKGSANGGNMFSSEVDSGLLS YLRKHNTGEEYLFATLTTVTAAPYIIYENESVMAMGGFNGTDPILTVSELKKLIKEGK VKYFLLSENNSGNSELVSWIKKNGKEITSDEYSGSSSSTNSVQGMRRGPGGESQQTLY LVE*" /label="yycA CDS" gene 3661989..3664046 /gene="yycA" /locus_tag="BSU_40490" /old_locus_tag="BSU40490" /label="yycA gene" downshifts 3663911 /Source="Nicolas_upshifts" /id="D2096" /incds=1 /nref=43 /ntot=203 /MaxReadThrough="1.96363" /MaxDrop="3.65354" /score="19.8733078" /energy="-16.6" /TU="NA" /idTUdmin="U3189" /TUdmin=1562 /isTUend="FALSE" /label="downshifts" CDS complement(3664083..3664532) /gene="rplI" /locus_tag="BSU_40500" /old_locus_tag="BSU40500" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9000630, 9588797, 11399077, 12682299, 14586115, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9000630, 9588797, 11399077, 12682299, 14586115, 23002217; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L9" /protein_id="NP_391930.1" /db_xref="EnsemblGenomes-Gn:BSU40500" /db_xref="EnsemblGenomes-Tr:CAB16087" /db_xref="GOA:P37437" /db_xref="InterPro:IPR000244" /db_xref="InterPro:IPR009027" /db_xref="InterPro:IPR020069" /db_xref="InterPro:IPR020070" /db_xref="InterPro:IPR020594" /db_xref="InterPro:IPR036791" /db_xref="InterPro:IPR036935" /db_xref="SubtiList:BG10009" /db_xref="UniProtKB/Swiss-Prot:P37437" /translation="MKVIFLQDVKGKGKKGEVKNVADGYAHNFLIKKGLAVEANASNI SALNGQKQKEKKEAIAELEQAKSLKETLEKLTVELSAKSGEGGRLFGSVTSKQITEQL QKDHNIKVDKRKLELPDGIRALGYTNVPVKLHPEVQAVLKVHVKEEA*" /label="rplI CDS" gene complement(3664083..3664532) /gene="rplI" /locus_tag="BSU_40500" /old_locus_tag="BSU40500" /label="rplI gene" downshifts complement(3664097) /Source="Nicolas_upshifts" /id="D2097" /incds=0 /nref=231 /ntot=266 /MaxReadThrough="2.69721" /MaxDrop="6.57383" /score="44.1169256" /energy="-16.6" /TU="NA" /idTUdmin="U3191" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3664529..3666508) /gene="gdpP" /locus_tag="BSU_40510" /old_locus_tag="BSU40510" /EC_number="3.1.4.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19901023, 19553197, 21257773, 21566650, 24465894, 24680501, 25616256, 26240071, 27150552, 28069645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19901023, 19553197, 21257773, 21566650, 24465894, 24680501, 25616256, 26240071, 27150552, 28069645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphodiesterase acting on cyclic dinucleotides" /protein_id="NP_391931.1" /db_xref="EnsemblGenomes-Gn:BSU40510" /db_xref="EnsemblGenomes-Tr:CAB16088" /db_xref="GOA:P37484" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR014528" /db_xref="SubtiList:BG10010" /db_xref="UniProtKB/Swiss-Prot:P37484" /translation="MPSFYEKPLFRYPIYALIALSIITILISFYFNWILGTVEVLLLA VILFFIKRADSLIRQEIDAYISTLSYRLKKVGEEALMEMPIGIMLFNDQYYIEWANPF LSSCFNESTLVGRSLYDTCESVVPLIKQEVESETVTLNDRKFRVVIKRDERLLYFFDV TEQIQIEKLYENERTVLAYIFLDNYDDVTQGLDDQTRSTMNSQVTSLLNAWAQEYGIF LKRTSSERFIAVLNEHILTELENSKFSILDEVREKTSFDGVALTLSVGVGASVSSLKE LGDLAQSSLDLALGRGGDQVAIKLPNGKVKFYGGKTNPMEKRTRVRARVISHALKEIV TESSNVIIMGHKFPDMDSIGAAIGILKVAQANNKDGFIVIDPNQIGSSVQRLIGEIKK YEELWSRFITPEEAMEISNDDTLLVIVDTHKPSLVMEERLVNKIEHIVVIDHHRRGEE FIRDPLLVYMEPYASSTAELVTELLEYQPKRLKINMIEATALLAGIIVDTKSFSLRTG SRTFDAASYLRAKGADTVLVQKFLKETVDSYIKRAKLIQHTVLYKDNIAIASLPENEE EYFDQVLIAQAADSLLSMSEVEASFAVARRDEQTVCISARSLGEVNVQIIMEALEGGG HLTNAATQLSGISVSEALERLKHAIDEYFEGGVQR*" /label="gdpP CDS" gene complement(3664529..3666508) /gene="gdpP" /locus_tag="BSU_40510" /old_locus_tag="BSU40510" /label="gdpP gene" misc_feature complement(3665010..3665029) /Source="Nicolas_upshift_promotors" /id="U3191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.454545454545455" /psig="0.997002997002997" /xcortree=2666 /SigmaFactorBS="cgaagcgcttaaaaatcaatatgattgaagcaacagccctat taGCTGGTATAATAGTGGATACaaagagcttttctctccgcacgggctcgcggacttt c" /listShort="rplI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3665013) /Source="Nicolas_upshifts" /id="U3191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.454545454545455" /psig="0.997002997002997" /xcortree=2666 /SigmaFactorBS="cgaagcgcttaaaaatcaatatgattgaagcaacagccctat taGCTGGTATAATAGTGGATACaaagagcttttctctccgcacgggctcgcggacttt c" /listShort="rplI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3665426..3665433 /Source="Nicolas_upshift_promotors" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3665447..3665465 /Source="Nicolas_upshift_promotors" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3665451..3666117 /Source="Nicolas_S_feature" /locus_tag="new_4164565_4165231" /HighExp="LBGstat, C30, Cold, GM 10, GM 25, GM 15, GM-0.1, GM 45, GM 120, GM 90" /AntisenseName="yybT" /AntisenseCor="0.145393098609886" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1559" upshifts 3665451 /Source="Nicolas_upshifts" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3666545..3667474) /gene="yybS" /locus_tag="BSU_40520" /old_locus_tag="BSU40520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22956758; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391932.1" /db_xref="EnsemblGenomes-Gn:BSU40520" /db_xref="EnsemblGenomes-Tr:CAB16089" /db_xref="InterPro:IPR018710" /db_xref="SubtiList:BG10011" /db_xref="UniProtKB/Swiss-Prot:P37485" /translation="MKQTRALMEGAILISLFAIITLLVVYVPVIGTILLFALPLPMIL YTIRHGLKLGIWMGAVSLPVVFIVGSFNGLIVAFMSACAGIAMGHFFKRKEPGHAIIS GALIYMLSIVFYFVISIQFLGINIIDEAMTQYRQSLDIVETVAKQSGNAGQFEKQLKL MEEQLGIVQYLFPTAIVMVGVIFSFLSYLIAKPLLRRFSPDIPNLKPFRELKFPQSVV VLYLIIVMLSFLPLEKGQMLYSIALNGEFILGFLIFIQGLSFIFFYCHKKQYPKAAAV IAVILGFVHPVFMAAIRILGVLDMGFHIRNKVK*" /label="yybS CDS" gene complement(3666545..3667474) /gene="yybS" /locus_tag="BSU_40520" /old_locus_tag="BSU40520" /label="yybS gene" S_feature complement(3667475..3667611) /Source="Nicolas_S_feature" /locus_tag="new_4166589_4166725_c" /HighExp="H2O2, G150, G180, Cold, Paraq, G135, Oxctl, Salt, Etha, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1560" promotor_-10 complement(3667593..3667612) /Source="Nicolas_upshift_promotors" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3667611) /Source="Nicolas_upshifts" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3667627..3667632) /Source="Nicolas_upshift_promotors" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3667701..3667850) /gene="yyzH" /locus_tag="BSU_40529" /old_locus_tag="BSU40529" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097802.1" /db_xref="EnsemblGenomes-Gn:BSU40529" /db_xref="EnsemblGenomes-Tr:CAX52718" /db_xref="GOA:C0H3U2" /db_xref="UniProtKB/Swiss-Prot:C0H3U2" /translation="MWDMIKNFFLFSSGVLQATTLLLVILIFMYVRKTKKKNKESSGF MDDKH*" /label="yyzH CDS" gene complement(3667701..3667850) /gene="yyzH" /locus_tag="BSU_40529" /old_locus_tag="BSU40529" /label="yyzH gene" downshifts complement(3667727) /Source="Nicolas_upshifts" /id="D2098" /incds=0 /nref=1 /ntot=44 /MaxReadThrough="6.98636" /MaxDrop="3.23568" /score="-6.7107279" /energy="-8.4" /TU="U3194" /idTUdmin="U3197" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3667889..3667908) /Source="Nicolas_upshift_promotors" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="promotor_-10" upshifts complement(3667906) /Source="Nicolas_upshifts" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="upshifts" promotor_-35 complement(3667922..3667928) /Source="Nicolas_upshift_promotors" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="promotor_-35" promotor_-35 3667929..3667938 /Source="Nicolas_upshift_promotors" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3667951..3667970 /Source="Nicolas_upshift_promotors" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3667957 /Source="Nicolas_upshifts" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3667969) /Source="Nicolas_upshifts" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3667971..3668484) /Source="Nicolas_S_feature" /locus_tag="new_4167085_4167598_c" /HighExp="dia5, Diami, H2O2, Salt, dia15, Etha, Paraq, LPhT, G180, C30" /AntisenseName="cotF" /AntisenseCor="-0.33406696665100499" /AntisenseRegPval="-7.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1561" promotor_-10 complement(3667973..3667987) /Source="Nicolas_upshift_promotors" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3667996..3668000) /Source="Nicolas_upshift_promotors" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3667996..3668478 /gene="cotF" /locus_tag="BSU_40530" /old_locus_tag="BSU40530" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1708381, 19933362, 23335421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1708381, 19933362, 23335421; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_391933.1" /db_xref="EnsemblGenomes-Gn:BSU40530" /db_xref="EnsemblGenomes-Tr:CAB16090" /db_xref="GOA:P23261" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="InterPro:IPR016493" /db_xref="SubtiList:BG10012" /db_xref="UniProtKB/Swiss-Prot:P23261" /translation="MDERRTLAWHETLEMHELVAFQSNGLIKLKKMIREVKDPQLRQL YNVSIQGVEQNLRELLPFFPQAPHREDEEEERADNPFYSGDLLGFAKTSVRSYAIAIT ETATPQLRNVLVKQLNAAIQLHAQVYRYMYQHGYYPSYNLSELLKNDVRNANRAISMK *" /label="cotF CDS" gene 3667996..3668478 /gene="cotF" /locus_tag="BSU_40530" /old_locus_tag="BSU40530" /label="cotF gene" downshifts 3668465 /Source="Nicolas_upshifts" /id="D2099" /incds=0 /nref=20 /ntot=52 /MaxReadThrough="5.45774" /MaxDrop="4.1869" /score="-3.60126456" /energy="-16.9" /TU="U3195" /idTUdmin="U3195" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" CDS complement(3668508..3668885) /gene="hypR" /locus_tag="BSU_40540" /old_locus_tag="BSU40540" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22238377" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22238377; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Cys-activated by oxidative stress)" /protein_id="NP_391934.1" /db_xref="EnsemblGenomes-Gn:BSU40540" /db_xref="EnsemblGenomes-Tr:CAB16091" /db_xref="GOA:P37486" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:4A5M" /db_xref="PDB:4A5N" /db_xref="SubtiList:BG10013" /db_xref="UniProtKB/Swiss-Prot:P37486" /translation="MSEKKNIYPNKEGCPVEFTLDVIGGKWKGILFYHMIDGKKRFNE FRRICPSITQRMLTLQLRELEADGIVHREVYHQVPPKVEYSLTEFGRTLEPIVLQMKE WGESNRDVLESYRSNGLVKDQQK*" /label="hypR CDS" gene complement(3668508..3668885) /gene="hypR" /locus_tag="BSU_40540" /old_locus_tag="BSU40540" /label="hypR gene" S_feature 3668510..3669039 /Source="Nicolas_S_feature" /locus_tag="new_4167624_4168153" /HighExp="S8, S6, S7, BT, S5, B36, C30, B60, G/S, Pyr" /AntisenseName="yybR" /AntisenseCor="-0.26586375565089998" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1562" downshifts complement(3668529) /Source="Nicolas_upshifts" /id="D2100" /incds=0 /nref=124 /ntot=240 /MaxReadThrough="4.32896" /MaxDrop="5.38963" /score="10.6464065" /energy="-15.3" /TU="U3197" /idTUdmin="U3197" /TUdmin="-802" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3668940..3668959) /Source="Nicolas_upshift_promotors" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3668952) /Source="Nicolas_upshifts" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3668973..3668980) /Source="Nicolas_upshift_promotors" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3669021..3669025 /Source="Nicolas_upshift_promotors" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3669039..3669058 /Source="Nicolas_upshift_promotors" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3669041 /Source="Nicolas_upshifts" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3669066..3669080) /Source="Nicolas_upshift_promotors" /id="U3199" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.553446553446553" /psig="0.393606393606394" /xcortree=309 /SigmaFactorBS="tatctgggttttggtgtccgaaaataagtatctttTcCATga tagctccTATCCTTTTTTAAGTagtgtaatctttatatagtttaacacgtcttgctgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3669069) /Source="Nicolas_upshifts" /id="U3199" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.553446553446553" /psig="0.393606393606394" /xcortree=309 /SigmaFactorBS="tatctgggttttggtgtccgaaaataagtatctttTcCATga tagctccTATCCTTTTTTAAGTagtgtaatctttatatagtttaacacgtcttgctgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 3669090..3670019 /gene="ppaC" /locus_tag="BSU_40550" /old_locus_tag="BSU40550" /EC_number="3.6.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9782505, 12682299, 15044829, 17611193, 9782505, 21749987, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9782505, 12682299, 15044829, 17611193, 9782505, 21749987, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inorganic pyrophosphatase (Mn2+-dependent)" /protein_id="NP_391935.1" /db_xref="EnsemblGenomes-Gn:BSU40550" /db_xref="EnsemblGenomes-Tr:CAB16092" /db_xref="GOA:P37487" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR004097" /db_xref="InterPro:IPR022934" /db_xref="PDB:1K23" /db_xref="PDB:1WPM" /db_xref="PDB:1WPN" /db_xref="PDB:2HAW" /db_xref="PDB:2IW4" /db_xref="SubtiList:BG10014" /db_xref="UniProtKB/Swiss-Prot:P37487" /translation="MEKILIFGHQNPDTDTICSAIAYADLKNKLGFNAEPVRLGQVNG ETQYALDYFKQESPRLVETAANEVNGVILVDHNERQQSIKDIEEVQVLEVIDHHRIAN FETAEPLYYRAEPVGCTATILNKMYKENNVKIEKEIAGLMLSAIISDSLLFKSPTCTD QDVAAAKELAEIAGVDAEEYGLNMLKAGADLSKKTVEELISLDAKEFTLGSKKVEIAQ VNTVDIEDVKKRQAELEAVISKVVAEKNLDLFLLVITDILENDSLALAIGNEAAKVEK AFNVTLENNTALLKGVVSRKKQVVPVLTDAMAE*" /label="ppaC CDS" gene 3669090..3670019 /gene="ppaC" /locus_tag="BSU_40550" /old_locus_tag="BSU40550" /label="ppaC gene" downshifts 3670005 /Source="Nicolas_upshifts" /id="D2101" /incds=0 /nref=235 /ntot=270 /MaxReadThrough="2.06965" /MaxDrop="8.02492" /score="25.8885382" /energy="-11.7" /TU="NA" /idTUdmin="U3195" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3670048) /Source="Nicolas_upshifts" /id="D2102" /incds=0 /nref=14 /ntot=136 /MaxReadThrough="1.08899" /MaxDrop="4.94065" /score="19.3488922" /energy="-11.7" /TU="NA" /idTUdmin="U3200" /TUdmin=33 /isTUend="FALSE" /label="downshifts" CDS complement(3670052..3670498) /gene="yybP" /locus_tag="BSU_40560" /old_locus_tag="BSU40560" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15096624, 25794618, 25794619; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative manganese-binding lipoprotein" /protein_id="NP_391936.1" /db_xref="EnsemblGenomes-Gn:BSU40560" /db_xref="EnsemblGenomes-Tr:CAB16093" /db_xref="GOA:P37488" /db_xref="SubtiList:BG10015" /db_xref="UniProtKB/Swiss-Prot:P37488" /translation="MKIILTVLAGVGLLSAGGCGMLDQVNDGLNYTSEAAGYVEKVKT FAEEAPELAEKAVNDTEAKEKLEAQLESIQKAAADFNELTPPDAAAEIHRTIQEHNET LQKSAEDVLKQAEEGKVSLKELEQSDLVQNAKQITDVMGQIEKLGE*" /label="yybP CDS" gene complement(3670052..3670498) /gene="yybP" /locus_tag="BSU_40560" /old_locus_tag="BSU40560" /label="yybP gene" S_feature complement(3670499..3670829) /Source="Nicolas_S_feature" /locus_tag="new_4169613_4169943_c" /HighExp="S8, Cold, S7, S6, H2O2, S5, S4, Etha, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.998614" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1563" misc_RNA complement(3670688..3670805) /gene="mswM" /locus_tag="BSU_misc_RNA_94" /product="manganese ion binding riboswitch" /experiment="publication(s) with functional evidences, PMID:25794618, 25794619" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25794618, 25794619; Product type n: RNA" /label="mswM RNA" gene complement(3670688..3670805) /gene="mswM" /locus_tag="BSU_misc_RNA_94" /label="mswM gene" promotor_-10 complement(3670820..3670839) /Source="Nicolas_upshift_promotors" /id="U3200" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig=1 /xcortree=672 /SigmaFactorBS="cacagcgcgcttttatataaacggcaggAATTTGACtggaac agatcggTGCTTTAGAATGAAAGTAATaaaaatgaacactccaaaggggagtagcttt c" /listShort="S1563, yybP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3670828) /Source="Nicolas_upshifts" /id="U3200" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig=1 /xcortree=672 /SigmaFactorBS="cacagcgcgcttttatataaacggcaggAATTTGACtggaac agatcggTGCTTTAGAATGAAAGTAATaaaaatgaacactccaaaggggagtagcttt c" /listShort="S1563, yybP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3670853..3670860) /Source="Nicolas_upshift_promotors" /id="U3200" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig=1 /xcortree=672 /SigmaFactorBS="cacagcgcgcttttatataaacggcaggAATTTGACtggaac agatcggTGCTTTAGAATGAAAGTAATaaaaatgaacactccaaaggggagtagcttt c" /listShort="S1563, yybP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3670866..3670872 /Source="Nicolas_upshift_promotors" /id="U3201" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=178 /SigmaFactorBS="tttcattctaaagcaccgatctgttccagtcaaattcctgcC GTTTATataaaagcgcgctgTGGTATTTAAAATTTGAATggtttttctatcaggagat c" /listShort="yybO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3670885 /Source="Nicolas_upshifts" /id="U3201" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=178 /SigmaFactorBS="tttcattctaaagcaccgatctgttccagtcaaattcctgcC GTTTATataaaagcgcgctgTGGTATTTAAAATTTGAATggtttttctatcaggagat c" /listShort="yybO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3670887..3670905 /Source="Nicolas_upshift_promotors" /id="U3201" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=178 /SigmaFactorBS="tttcattctaaagcaccgatctgttccagtcaaattcctgcC GTTTATataaaagcgcgctgTGGTATTTAAAATTTGAATggtttttctatcaggagat c" /listShort="yybO" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3670901..3670907 /Source="Nicolas_upshift_promotors" /id="U3202" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=736 /SigmaFactorBS="ttatataaaagcgcgctgtggtatttaaaattTGAATGGttt ttctatcaggaGATCATGCTATGacagaggaggttttcatcatgagtcaagagcgcgt g" /listShort="yybO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3670922..3670933 /Source="Nicolas_upshift_promotors" /id="U3202" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=736 /SigmaFactorBS="ttatataaaagcgcgctgtggtatttaaaattTGAATGGttt ttctatcaggaGATCATGCTATGacagaggaggttttcatcatgagtcaagagcgcgt g" /listShort="yybO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3670929 /Source="Nicolas_upshifts" /id="U3202" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=736 /SigmaFactorBS="ttatataaaagcgcgctgtggtatttaaaattTGAATGGttt ttctatcaggaGATCATGCTATGacagaggaggttttcatcatgagtcaagagcgcgt g" /listShort="yybO" /GFF_Attribute="listLong" /label="upshifts" CDS 3670931..3672238 /gene="yybO" /locus_tag="BSU_40570" /old_locus_tag="BSU40570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_391937.1" /db_xref="EnsemblGenomes-Gn:BSU40570" /db_xref="EnsemblGenomes-Tr:CAB16094" /db_xref="GOA:P37489" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10016" /db_xref="UniProtKB/Swiss-Prot:P37489" /translation="MTEEVFIMSQERVKRPGHTRWYISSLLSGIIILNYFDRVAISVA APAIQDSFHLTATELGIVFSIYTYSYTLMQLPVGSLLDRFGVAWVTRVGMTIWSFLTI LLAFLQGKLLLYLFRFLIGLTSASAFPAASKATALWFPPSERGLANSLFDSAAKFSNV IGAPLVAFLVTTFDWRVAFLTIGCINVLFTIFFWQYYEQPERHKRISKSELNYIQKHN AITTEQIPYKTGPLLKKLFTNRKVWGLMIGFTGYGYTFNLLLTWLPTFFKHTYGMDLM SSGLFTAVPWLISTISGIAVGGWLVDYFIKKGYPNTKVYRTVIIVGMSFGFFFLGSIL TNNITVAIICISIGLAGISATAPVGWSISAELAPIGSVSMLSSMVNLANNLFGGIIAA SLTGYLFDVTGSFTLSFLVAGFVLLLGLVFYVFVLGDVKRIKL*" /label="yybO CDS" gene 3670931..3672238 /gene="yybO" /locus_tag="BSU_40570" /old_locus_tag="BSU40570" /label="yybO gene" downshifts complement(3672039) /Source="Nicolas_upshifts" /id="D2103" /incds=1 /nref=1 /ntot=11 /MaxReadThrough="0.73662" /MaxDrop="2.97868" /score="30.543563" /energy="-17.9" /TU="NA" /idTUdmin="U3203" /TUdmin=264 /isTUend="FALSE" /label="downshifts" downshifts 3672227 /Source="Nicolas_upshifts" /id="D2104" /incds=0 /nref=7 /ntot=55 /MaxReadThrough="2.76545" /MaxDrop="3.99898" /score="-3.44083304" /energy="-17.9" /TU="NA" /idTUdmin="U3201" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3672282..3672521) /gene="yyzI" /locus_tag="BSU_40573" /old_locus_tag="BSU40573" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52719.1" /translation="MNYKKQNQGFGSISGDHNDIHDILATIEENGTQDAFHYEGGLQG KNEQVLEQIEQEMLASGLDIEEQDEEKVNGDGPIL*" /label="yyzI CDS" gene complement(3672282..3672521) /gene="yyzI" /locus_tag="BSU_40573" /old_locus_tag="BSU40573" /pseudo /label="yyzI gene" downshifts complement(3672303) /Source="Nicolas_upshifts" /id="D2105" /incds=0 /nref=4 /ntot=114 /MaxReadThrough="3.05613" /MaxDrop="4.69729" /score="30.543563" /energy="-17.9" /TU="NA" /idTUdmin="U3203" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(3672307..3672407) /Source="Nicolas_upshift_promotors" /id="U3203" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.552447552447552" /psig="0.010989010989011" /xcortree=1485 /SigmaFactorBS="gaaggtggtcttcaaggaaaaaacgagcaggtgctcgaacag atagagcaggaaatgctagcttcggggcttgatatagaggaacaggacgaggagaagg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3672347) /Source="Nicolas_upshifts" /id="U3203" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.552447552447552" /psig="0.010989010989011" /xcortree=1485 /SigmaFactorBS="gaaggtggtcttcaaggaaaaaacgagcaggtgctcgaacag atagagcaggaaatgctagcttcggggcttgatatagaggaacaggacgaggagaagg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3672511..3672675) /gene="yyzJ" /locus_tag="BSU_40574" /old_locus_tag="BSU40574" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52720.1" /translation="MMIRGIHLEQQLKDIISACDVAIQNEDFDTLMNYYSERIMCKPR KQPPQRFCEL*" /label="yyzJ CDS" gene complement(3672511..3672675) /gene="yyzJ" /locus_tag="BSU_40574" /old_locus_tag="BSU40574" /pseudo /label="yyzJ gene" CDS complement(3672687..3672872) /locus_tag="BSU_40576" /old_locus_tag="BSU40576" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514014.1" /translation="MSHQTKYPVNEAAIMPSNRLFARFTMELSMDTEPIGASSAEMDQ RNRKNKNEKDPYVSNIV*" /label="hypothetical protein CDS" gene complement(3672687..3672872) /locus_tag="BSU_40576" /old_locus_tag="BSU40576" /label="gene" downshifts 3672953 /Source="Nicolas_upshifts" /id="D2106" /incds=0 /nref=13 /ntot=90 /MaxReadThrough="0.18425" /MaxDrop="3.85413" /score="3.91893698" /energy="-13.7" /TU="NA" /idTUdmin="U3201" /TUdmin=726 /isTUend="FALSE" /label="downshifts" CDS complement(3673145..3673291) /gene="yyzK" /locus_tag="BSU_40578" /old_locus_tag="BSU40578" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52721.1" /translation="MYGKTIKKRLEKIAFLFQEISKKRKEKIERSFVGSKQLHGLSYR RFRG*" /label="yyzK CDS" gene complement(3673145..3673291) /gene="yyzK" /locus_tag="BSU_40578" /old_locus_tag="BSU40578" /pseudo /label="yyzK gene" CDS complement(3673273..3673422) /gene="yyzL" /locus_tag="BSU_40579" /old_locus_tag="BSU40579" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52722.1" /translation="MLNQHTLTYSTIDRKDYRSYKSNPEICLRILHKINETPESRYSV CMAKP*" /label="yyzL CDS" gene complement(3673273..3673422) /gene="yyzL" /locus_tag="BSU_40579" /old_locus_tag="BSU40579" /pseudo /label="yyzL gene" misc_feature complement(3673738..3673754) /Source="Nicolas_upshift_promotors" /id="U3204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.330669330669331" /psig="0.761238761238761" /xcortree=650 /SigmaFactorBS="agattaactatattatatcttaactgtaataacctgtaaaga attttattgatagtattggATTTTATGTTATAAAGGaaaaagggtgggcgatttgctc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3673755) /Source="Nicolas_upshifts" /id="U3204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.330669330669331" /psig="0.761238761238761" /xcortree=650 /SigmaFactorBS="agattaactatattatatcttaactgtaataacctgtaaaga attttattgatagtattggATTTTATGTTATAAAGGaaaaagggtgggcgatttgctc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3673774..3673781 /Source="Nicolas_upshift_promotors" /id="U3205" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2295 /SigmaFactorBS="ttcctttataacataaaatccaatactatcaataaaatTCTT TACAggttattacagttaAGATATAATATAGTTAATCTtttacgtaaaaggaggtttt t" /listShort="S1564, yybN, S1565, yybM, yybL, yybK, yybJ, S1567" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3673796..3673999 /Source="Nicolas_S_feature" /locus_tag="new_4172910_4173113" /HighExp="nit, T-3.40H, T-1.40H, T-0.40H, T0.0H, SMMPr, SMM, LoTm, ferm, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1564" promotor_-10 3673796..3673815 /Source="Nicolas_upshift_promotors" /id="U3205" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2295 /SigmaFactorBS="ttcctttataacataaaatccaatactatcaataaaatTCTT TACAggttattacagttaAGATATAATATAGTTAATCTtttacgtaaaaggaggtttt t" /listShort="S1564, yybN, S1565, yybM, yybL, yybK, yybJ, S1567" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3673796 /Source="Nicolas_upshifts" /id="U3205" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2295 /SigmaFactorBS="ttcctttataacataaaatccaatactatcaataaaatTCTT TACAggttattacagttaAGATATAATATAGTTAATCTtttacgtaaaaggaggtttt t" /listShort="S1564, yybN, S1565, yybM, yybL, yybK, yybJ, S1567" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3673817..3673831) /Source="Nicolas_upshift_promotors" /id="U3206" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=295 /SigmaFactorBS="tggggagatggagttactcctatttaaaacttcaacacaagt aataaaaaCCTCCTTTTACGTAAaagattaactatattatatcttaactgtaataacc t" /listShort="yyzL, yyzK" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3673821) /Source="Nicolas_upshifts" /id="U3206" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=295 /SigmaFactorBS="tggggagatggagttactcctatttaaaacttcaacacaagt aataaaaaCCTCCTTTTACGTAAaagattaactatattatatcttaactgtaataacc t" /listShort="yyzL, yyzK" /GFF_Attribute="listLong" /label="upshifts" CDS 3674000..3674437 /gene="yybN" /locus_tag="BSU_40580" /old_locus_tag="BSU40580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27902860" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391938.1" /db_xref="EnsemblGenomes-Gn:BSU40580" /db_xref="EnsemblGenomes-Tr:CAB16095" /db_xref="InterPro:IPR020208" /db_xref="SubtiList:BG10017" /db_xref="UniProtKB/Swiss-Prot:P37490" /translation="MNKFLKSNFRFLLAAALGISLLASSNFIKASNDNYKFHLLVPYG YGNAYSNDAFRQTTHTDNPWKVNLQKSAEGKGTIMTFWLINTGNSKIPKASKIHNVKQ GSGAHYYHANSQGSHTYVALAVENNNYSASSYGIDGVWDEETW*" /label="yybN CDS" gene 3674000..3674437 /gene="yybN" /locus_tag="BSU_40580" /old_locus_tag="BSU40580" /label="yybN gene" S_feature 3674438..3674514 /Source="Nicolas_S_feature" /locus_tag="new_4173552_4173628" /HighExp="M9-tran, SMMPr, MG 120, aero, GM 120, SMM, T-2.40H, T-4.40H, nit, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1565" downshifts 3674471 /Source="Nicolas_upshifts" /id="D2107" /incds=0 /nref=10 /ntot=98 /MaxReadThrough="6.91942" /MaxDrop="3.8662" /score="9.16494325" /energy="-9.5" /TU="U3205" /idTUdmin="U3201" /TUdmin=2244 /isTUend="FALSE" /label="downshifts" CDS 3674551..3675306 /gene="yybM" /locus_tag="BSU_40590" /old_locus_tag="BSU40590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter permease subunit" /protein_id="NP_391939.1" /db_xref="EnsemblGenomes-Gn:BSU40590" /db_xref="EnsemblGenomes-Tr:CAB16096" /db_xref="SubtiList:BG10018" /db_xref="UniProtKB/Swiss-Prot:P37491" /translation="MESHIYRIIKNKLTIIIFTIIILIPCVDISLLLMTNTEYHPAYA FFLSGTSVGHASQMILLWFLPLYFLLLCADDSIQDYKTGYHYILISKVGRKKYCLEKI FTSFIISFLTMFLSLILNFLLVQVFFFKGTFKNDLDQIKFPDNSLYTFSMAHPYIAIV LFSIICCIMSGFVGALGSSLSLLFRDKKYAYPASFFIWFVLILKNKSLMFLFQPFTEY GYNVLLPILCLSIFIFLIIISSIVLYEAKYNEN*" /label="yybM CDS" gene 3674551..3675306 /gene="yybM" /locus_tag="BSU_40590" /old_locus_tag="BSU40590" /label="yybM gene" S_feature complement(3675146..3677735) /Source="Nicolas_S_feature" /locus_tag="new_4174260_4176850_c" /HighExp="S8, S6, S4, S5, S7, S3, C30, BT, G135, T5.0H" /AntisenseName="yybK" /AntisenseCor="-0.46686696237140402" /AntisenseRegPval="-15.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1566" CDS 3675296..3676006 /gene="yybL" /locus_tag="BSU_40600" /old_locus_tag="BSU40600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative transporter permease subunit" /protein_id="NP_391940.1" /db_xref="EnsemblGenomes-Gn:BSU40600" /db_xref="EnsemblGenomes-Tr:CAB16097" /db_xref="SubtiList:BG10019" /db_xref="UniProtKB/Swiss-Prot:P37492" /translation="MKIKRLLLILCLLLFLVTLWFNQNHTYLGKNSIASLLYMNNSTF GYSSIFAYTLFYIVPFLMLLSNFFHSENPYKVMRMVKRKNYYKSKIMEIGFVSLLFSS IHTVINITCTHIFFSKNLLVEANFLSICLLNMISLVFFYLSVGIMFRLTYDLFNSVAL AIFIVYIILDSLYFGVKLLLPNGYWEPFRDLAIFTNMLNRYWSTSNLIIVYIRQIIIV FIFYLVGSSIFLNKDYKK*" /label="yybL CDS" gene 3675296..3676006 /gene="yybL" /locus_tag="BSU_40600" /old_locus_tag="BSU40600" /label="yybL gene" downshifts 3675505 /Source="Nicolas_upshifts" /id="D2108" /incds=1 /nref=1 /ntot=11 /MaxReadThrough="7.39982" /MaxDrop="2.95139" /score="9.16494325" /energy="-9.5" /TU="U3205" /idTUdmin="U3205" /TUdmin="-2354" /isTUend="FALSE" /label="downshifts" CDS 3676003..3676758 /gene="yybK" /locus_tag="BSU_40610" /old_locus_tag="BSU40610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative transporter permease subunit" /protein_id="NP_391941.1" /db_xref="EnsemblGenomes-Gn:BSU40610" /db_xref="EnsemblGenomes-Tr:CAB16098" /db_xref="InterPro:IPR024295" /db_xref="SubtiList:BG10020" /db_xref="UniProtKB/Swiss-Prot:P37493" /translation="MRIKGFFITLVAIIFQASLSSYNNNKNVFPFLDGIPISTSGHYE YQNILLWFVPIVSLSFCFSGSIRDTYISYEQLKLVREHSRVKWVTSQFLIITVVLLIF TLSQIAIFYIYSLVSLHNLDINSVINKRFVMMTLMYYLTLLNLFSFQLFMELYYKSQI AQLNISVYIIFSLILAKKLVQLNSPKVIHYFLIPNYSNGLRTGLSYYSQSGTAIIEPL LGLFIIIILQISIVILSVLKFKKIDMLKSEGLQ*" /label="yybK CDS" gene 3676003..3676758 /gene="yybK" /locus_tag="BSU_40610" /old_locus_tag="BSU40610" /label="yybK gene" CDS 3676755..3677410 /gene="yybJ" /locus_tag="BSU_40620" /old_locus_tag="BSU40620" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1938973; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-binding cassette subunit of transporter" /protein_id="NP_391942.1" /db_xref="EnsemblGenomes-Gn:BSU40620" /db_xref="EnsemblGenomes-Tr:CAB16099" /db_xref="GOA:P37494" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10021" /db_xref="UniProtKB/Swiss-Prot:P37494" /translation="MIEVLNLTKKLKRLQF*IISLIHLKKEQFMDYLGVMVLERPCYF VHYPG**SLLKGV*LLKVNNYIKISLFLKV*D*L*KICSYFLSMMLLLTLKFCQKLKR SHQIMIY*ILLVELVWKILIV*RLVNSR*E*NND*ILHRLFLKNLIYCYLMNQQMRLM KKELHLFMTFFYKRKKGELPLLLLVITRKILYLYVTLH*K*IMDV*KLQKK*YIRKIV " /label="yybJ CDS" gene 3676755..3677410 /gene="yybJ" /locus_tag="BSU_40620" /old_locus_tag="BSU40620" /label="yybJ gene" S_feature 3677411..3677725 /Source="Nicolas_S_feature" /locus_tag="new_4176526_4176840" /HighExp="aero, Cold, HPh, nit, M/G, M9-tran, S1, SMM, LPh, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1567" downshifts 3677682 /Source="Nicolas_upshifts" /id="D2109" /incds=0 /nref=93 /ntot=227 /MaxReadThrough="3.45614" /MaxDrop="4.54398" /score="2.19825508" /energy="-10.3" /TU="U3205" /idTUdmin="U3205" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts 3677726 /Source="Nicolas_upshifts" /id="D2110" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.98662" /MaxDrop="3.29879" /score="2.19825508" /energy="-10.3" /TU="U3205" /idTUdmin="U3205" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts complement(3677780) /Source="Nicolas_upshifts" /id="D2111" /incds=0 /nref=1 /ntot=24 /MaxReadThrough="3.53364" /MaxDrop="2.25148" /score="10.1219981" /energy="-6.3" /TU="U3207" /idTUdmin="U3209" /TUdmin=2266 /isTUend="FALSE" /label="downshifts" CDS complement(3677785..3678573) /gene="ictI" /locus_tag="BSU_40630" /old_locus_tag="BSU40630" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16321932, 22882546, 25835496" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16321932, 22882546, 25835496; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391943.1" /db_xref="EnsemblGenomes-Gn:BSU40630" /db_xref="EnsemblGenomes-Tr:CAB16100" /db_xref="SubtiList:BG10022" /db_xref="UniProtKB/Swiss-Prot:P37495" /translation="MNVYDIRMAPYWFYEGRGLVQHPYVFRQPVSSRAIIVSTRGDVT GDGVIDEVFLTGNQMPGSPLWRNITLVIRDGRTHQEQRIQLQNNMGYNPSLFLGDMTG DKIEDVAVVMDTGGSGGAIYAYVFAYLNRQFRRIFNSDVLNDELKYSVRYQNQYKASV ISHQQNETYILDLTYKGREYLNEIYNSQGVLKMPIEGWVNPLSGLYPVDFDRDGVYEL LAYQRIAGRYNADSLGYVQTVLKWNGQRFMFNRQTVTIFGSDLS*" /label="ictI CDS" gene complement(3677785..3678573) /gene="ictI" /locus_tag="BSU_40630" /old_locus_tag="BSU40630" /label="ictI gene" promotor_-10 complement(3678597..3678615) /Source="Nicolas_upshift_promotors" /id="U3207" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1128 /SigmaFactorBS="gataattcatatggtacggatttaattggtgtgtaagataTG TCTTtgatgtgccattcctGCATATAATGATTCATTCAgctgattagggaaggtgaca c" /listShort="yybI, S1566" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3678616) /Source="Nicolas_upshifts" /id="U3207" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1128 /SigmaFactorBS="gataattcatatggtacggatttaattggtgtgtaagataTG TCTTtgatgtgccattcctGCATATAATGATTCATTCAgctgattagggaaggtgaca c" /listShort="yybI, S1566" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3678631..3678636) /Source="Nicolas_upshift_promotors" /id="U3207" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1128 /SigmaFactorBS="gataattcatatggtacggatttaattggtgtgtaagataTG TCTTtgatgtgccattcctGCATATAATGATTCATTCAgctgattagggaaggtgaca c" /listShort="yybI, S1566" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3678641..3679030) /gene="yybH" /locus_tag="BSU_40640" /old_locus_tag="BSU40640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391944.1" /db_xref="EnsemblGenomes-Gn:BSU40640" /db_xref="EnsemblGenomes-Tr:CAB16101" /db_xref="InterPro:IPR009959" /db_xref="InterPro:IPR032710" /db_xref="PDB:2GXF" /db_xref="SubtiList:BG10023" /db_xref="UniProtKB/Swiss-Prot:P37496" /translation="MEQQLKDIISACDLAIQNEDFDTLMNYYSEDAVLVVKPGMIARG KEEIKKAFITIANYFNHHIVPTQGKMILLEAGDTVLVLSQTLLDSDKKDSEYAMERRA TYVFKKNAQGEWLCVIDNSYGTDLIGV*" /label="yybH CDS" gene complement(3678641..3679030) /gene="yybH" /locus_tag="BSU_40640" /old_locus_tag="BSU40640" /label="yybH gene" promotor_-35 3679099..3679102 /Source="Nicolas_upshift_promotors" /id="U3208" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.999000999001" /xcortree=2554 /SigmaFactorBS="tcgctagaccactgaaaccttgaaaacaaAATGaaaagtatc cttttTTCCTATATAATCAAATAGAtatatttaacaaagtacccaagtgaaggggtga a" /listShort="yybG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3679117..3679136 /Source="Nicolas_upshift_promotors" /id="U3208" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.999000999001" /xcortree=2554 /SigmaFactorBS="tcgctagaccactgaaaccttgaaaacaaAATGaaaagtatc cttttTTCCTATATAATCAAATAGAtatatttaacaaagtacccaagtgaaggggtga a" /listShort="yybG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3679130 /Source="Nicolas_upshifts" /id="U3208" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.999000999001" /xcortree=2554 /SigmaFactorBS="tcgctagaccactgaaaccttgaaaacaaAATGaaaagtatc cttttTTCCTATATAATCAAATAGAtatatttaacaaagtacccaagtgaaggggtga a" /listShort="yybG" /GFF_Attribute="listLong" /label="upshifts" CDS 3679176..3680015 /gene="yybG" /locus_tag="BSU_40650" /old_locus_tag="BSU40650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11709313, 12486061" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391945.1" /db_xref="EnsemblGenomes-Gn:BSU40650" /db_xref="EnsemblGenomes-Tr:CAB16102" /db_xref="InterPro:IPR001646" /db_xref="SubtiList:BG10024" /db_xref="UniProtKB/Swiss-Prot:P37497" /translation="MSAEVTLHDNIHYDLSADCQHCFGLCCVALPYAKSADFAFDKDG GTPCRNLQSNYQCSIHKDLREKGFRGCSAYECFGAGQKVSQITYEGKDWRNSPETANQ MFDVFPIMQQLHEMLWYLHEALSIDIAKPIHSELRTTFEKIERLTRLSKERLLTLQVD EHRAEVNEWLLKTSELVRAQARHPKLPKKVSRGSVLIGAKLKGLDLRGANLRGALLIA ADLRNADLRMTDFIGADMRDADLSGADLTGSIFLTQAQVNAANGDSNTKLPLSVRTPA HWK*" /label="yybG CDS" gene 3679176..3680015 /gene="yybG" /locus_tag="BSU_40650" /old_locus_tag="BSU40650" /label="yybG gene" downshifts 3679992 /Source="Nicolas_upshifts" /id="D2112" /incds=0 /nref=35 /ntot=188 /MaxReadThrough="1.19247" /MaxDrop="3.72166" /score="-0.156630814" /energy="-6.3" /TU="NA" /idTUdmin="U3208" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3680048..3681262) /gene="yybF" /locus_tag="BSU_40660" /old_locus_tag="BSU40660" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9811656, 11557812, 12486061, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_391946.1" /db_xref="EnsemblGenomes-Gn:BSU40660" /db_xref="EnsemblGenomes-Tr:CAB16103" /db_xref="GOA:P37498" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10025" /db_xref="UniProtKB/Swiss-Prot:P37498" /translation="MTYIRKGTPVFRKITFAFFAAGFNTFAILYCVQPLMEEFTREFH VTPTAASLSLSVTTMLLAVSMLVFGSLSEVWGRKPIMGISMLAASVLCLASAFSPSFH TLLVLRTIQGVALAGLPSIAMAYLGEEIEPGSLGSAMGLYISGNAIGAVFGRIVSGLL SEYLNWHMAMGTIGVISLIASVIFFINLPPSRHFTPRKLKLGKLGMSLIGHLRDRKLF SLFLIGFLLLGSNVALFNYIVYVLLGPPYSLNKAFSSWIFIVMIVGIFSSSFIGRMVD RYGYPKILVMNIFIVIAGALFTINNMLAVKILGIALFTFGFFGGHSVASSWVGRRALH NKAQASSLYLFFYYAGSSVFGTIGGLFWSGFHWLGVVGMITFMLLVALWLSGYLARSV KMPDKRNEKGLN*" /label="yybF CDS" gene complement(3680048..3681262) /gene="yybF" /locus_tag="BSU_40660" /old_locus_tag="BSU40660" /label="yybF gene" downshifts complement(3680066) /Source="Nicolas_upshifts" /id="D2113" /incds=0 /nref=45 /ntot=169 /MaxReadThrough="1.92237" /MaxDrop="5.70619" /score="10.1219981" /energy="-6.3" /TU="NA" /idTUdmin="U3209" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" S_feature complement(3681263..3681366) /Source="Nicolas_S_feature" /locus_tag="new_4180378_4180481_c" /HighExp="BI, B60, ferm, T0.30H, T-1.10H, T-0.40H, T-1.40H, T1.0H, nit, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.94819299999999995" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1568" promotor_-10 complement(3681359..3681378) /Source="Nicolas_upshift_promotors" /id="U3209" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.728271728271728" /psig="0.996003996003996" /xcortree=1589 /SigmaFactorBS="catataagcatgaaaaggatattttatatgCATTATACaaca tatatcaacGGTGCTAAGATAATAATATAaacagactcgaggatgtttgaattcgtaa g" /listShort="S1568, yybF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3681367..3681374 /Source="Nicolas_upshift_promotors" /id="U3210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.627372627372627" /psig="0.997002997002997" /xcortree=2542 /SigmaFactorBS="aaacatcctcgagtctgtttatattatTATCTTAGcaccgtt gatataTGTTGTATAATGCATATAAAatatccttttcatgcttatatgtaataaggag a" /listShort="yybE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3681369) /Source="Nicolas_upshifts" /id="U3209" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.728271728271728" /psig="0.996003996003996" /xcortree=1589 /SigmaFactorBS="catataagcatgaaaaggatattttatatgCATTATACaaca tatatcaacGGTGCTAAGATAATAATATAaacagactcgaggatgtttgaattcgtaa g" /listShort="S1568, yybF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3681388..3681407 /Source="Nicolas_upshift_promotors" /id="U3210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.627372627372627" /psig="0.997002997002997" /xcortree=2542 /SigmaFactorBS="aaacatcctcgagtctgtttatattatTATCTTAGcaccgtt gatataTGTTGTATAATGCATATAAAatatccttttcatgcttatatgtaataaggag a" /listShort="yybE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3681392..3681399) /Source="Nicolas_upshift_promotors" /id="U3209" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.728271728271728" /psig="0.996003996003996" /xcortree=1589 /SigmaFactorBS="catataagcatgaaaaggatattttatatgCATTATACaaca tatatcaacGGTGCTAAGATAATAATATAaacagactcgaggatgtttgaattcgtaa g" /listShort="S1568, yybF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3681400 /Source="Nicolas_upshifts" /id="U3210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.627372627372627" /psig="0.997002997002997" /xcortree=2542 /SigmaFactorBS="aaacatcctcgagtctgtttatattatTATCTTAGcaccgtt gatataTGTTGTATAATGCATATAAAatatccttttcatgcttatatgtaataaggag a" /listShort="yybE" /GFF_Attribute="listLong" /label="upshifts" CDS 3681449..3682327 /gene="yybE" /locus_tag="BSU_40670" /old_locus_tag="BSU40670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12169591, 17526699, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391947.2" /db_xref="EnsemblGenomes-Gn:BSU40670" /db_xref="EnsemblGenomes-Tr:CAB16104" /db_xref="GOA:P37499" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10026" /db_xref="UniProtKB/Swiss-Prot:P37499" /translation="MEWEQLEYFQTLARMQHVTKAAKSLSITQPALSRSIARLENHLG VPLFDRQGRSISLNQYGHIFLRRVQAMMKEYTEGKEEIQALLKPDQGVVSLGFLHTLG TTLVPDLIGSFQQEYPNISFQLKQNHSYWLLERLKSGDLDLCLLASIKPENPIQWIKL WSEELFVFVPNDHPLASRESITLNEIAGERFILLKKGYALRMTVDELFEKANIQPNIM FEGEEATTAAGFVAAGLGISILPDLKGLDQSKITKIRVSWPECQRVIGIAWIKGRFLS PVAETFKQYVISHFSE*" /label="yybE CDS" gene 3681449..3682327 /gene="yybE" /locus_tag="BSU_40670" /old_locus_tag="BSU40670" /label="yybE gene" CDS 3682341..3682784 /gene="yybD" /locus_tag="BSU_40680" /old_locus_tag="BSU40680" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_391948.1" /db_xref="EnsemblGenomes-Gn:BSU40680" /db_xref="EnsemblGenomes-Tr:CAB16105" /db_xref="GOA:P37500" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10027" /db_xref="UniProtKB/Swiss-Prot:P37500" /translation="MNVKKITSEQDLHTAFEIRKAVFVEEQGCPISDEFDEFDTLHGD CQHILAYHQNVPVGTARVRIVGHTGKLERICILKSYRKFGLGKVIVDALERIVKEQGI SAFKLHGQTQAAGFYEKLGYRTASEEFMLDGIPHVLMTKQDDSAL*" /label="yybD CDS" gene 3682341..3682784 /gene="yybD" /locus_tag="BSU_40680" /old_locus_tag="BSU40680" /label="yybD gene" CDS 3682867..3683346 /gene="yybC" /locus_tag="BSU_40690" /old_locus_tag="BSU40690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 28032445; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391949.1" /db_xref="EnsemblGenomes-Gn:BSU40690" /db_xref="EnsemblGenomes-Tr:CAB16106" /db_xref="SubtiList:BG10028" /db_xref="UniProtKB/Swiss-Prot:P37501" /translation="MPANKKEGLIFGVMMCFGMVCVMSIYNAIINRAIYDFSLMTVFE MVIGFMIALLLDLLLVGPLAKKIAFRMPFDKTKKIYVILAMSTCMVIGMVLCMSVFGL VTAVLANGLNGDSLFSAYLMIVLKNFILAYPLQLLIMGPLVRGVFMKFVKPKLTAAI* " /label="yybC CDS" gene 3682867..3683346 /gene="yybC" /locus_tag="BSU_40690" /old_locus_tag="BSU40690" /label="yybC gene" downshifts 3683336 /Source="Nicolas_upshifts" /id="D2114" /incds=0 /nref=13 /ntot=97 /MaxReadThrough="0.69144" /MaxDrop="3.55998" /score="-9.53342462" /energy="-10.9" /TU="NA" /idTUdmin="U3210" /TUdmin=1628 /isTUend="FALSE" /label="downshifts" CDS complement(3683521..3684183) /gene="yybB" /locus_tag="BSU_40700" /old_locus_tag="BSU40700" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391950.1" /db_xref="EnsemblGenomes-Gn:BSU40700" /db_xref="EnsemblGenomes-Tr:CAB16107" /db_xref="GOA:P37502" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG10029" /db_xref="UniProtKB/Swiss-Prot:P37502" /translation="MNLRQLSEHVFQCEFELDVPLRIPVHTWFIKDGDDVYIVDTGIE RFADAQIRAALAIGNPKAILLTHGHSDHIGGASKWLERFDIPIFAHQKELKYINGEEP YPNKNEVENTGVAHIVQPLTEQTLAHLPLKYYLTPGHSPGHVVYYHKIDRTLLTGDLF ITSKEDLHPPIRRFSVDINENIDSGSIIDQIKPTLICSSHGEEILYNEELYKNYVVRY RD*" /label="yybB CDS" gene complement(3683521..3684183) /gene="yybB" /locus_tag="BSU_40700" /old_locus_tag="BSU40700" /label="yybB gene" CDS complement(3684330..3684782) /gene="yybA" /locus_tag="BSU_40710" /old_locus_tag="BSU40710" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MarR family, polyamine export and degradation)" /protein_id="NP_391951.1" /db_xref="EnsemblGenomes-Gn:BSU40710" /db_xref="EnsemblGenomes-Tr:CAB16108" /db_xref="GOA:P37503" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10030" /db_xref="UniProtKB/Swiss-Prot:P37503" /translation="MNDILREIGMIARALDSISNIEFKDLDLTRGQYLYLVRIYENPG IIQEKLAEMIKVDRTTAARAIKKLEMQGFIQKLPDEQNKKIKKLFPTEKGKKVYPLLR REGEHSTEVALSGFTSEEKETISALLHRVRKNIERDWEYVKKGNKRDY*" /label="yybA CDS" gene complement(3684330..3684782) /gene="yybA" /locus_tag="BSU_40710" /old_locus_tag="BSU40710" /label="yybA gene" promotor_-35 3684806..3684813 /Source="Nicolas_upshift_promotors" /id="U3211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.706293706293706" /psig="0.998001998001998" /xcortree=1783 /SigmaFactorBS="aaatatcattcattcctaaaacccctcacgtattttTGTTGC AAttacaacaaaaatgTTTTAACCTTACTATTATAAgaccacatgcgtgctgtacagt c" /listShort="S1569, yyaT, yyaS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3684828..3684847 /Source="Nicolas_upshift_promotors" /id="U3211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.706293706293706" /psig="0.998001998001998" /xcortree=1783 /SigmaFactorBS="aaatatcattcattcctaaaacccctcacgtattttTGTTGC AAttacaacaaaaatgTTTTAACCTTACTATTATAAgaccacatgcgtgctgtacagt c" /listShort="S1569, yyaT, yyaS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3684830 /Source="Nicolas_upshifts" /id="U3211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.706293706293706" /psig="0.998001998001998" /xcortree=1783 /SigmaFactorBS="aaatatcattcattcctaaaacccctcacgtattttTGTTGC AAttacaacaaaaatgTTTTAACCTTACTATTATAAgaccacatgcgtgctgtacagt c" /listShort="S1569, yyaT, yyaS" /GFF_Attribute="listLong" /label="upshifts" S_feature 3684832..3684901 /Source="Nicolas_S_feature" /locus_tag="new_4183947_4184016" /HighExp="G135, G180, H2O2, LoTm, G150, Salt, Diami, Paraq, LBGstat, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1569" promotor_-10 complement(3684835..3684854) /Source="Nicolas_upshift_promotors" /id="U3212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.992007992007992" /xcortree=2273 /SigmaFactorBS="aatcaatccttttctgatattagTCTGGACTgtacagcacgc aTGTGGTCTTATAATAGTAAGgttaaaacatttttgttgtaattgcaacaaaaatacg t" /listShort="yybA, yybB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3684837) /Source="Nicolas_upshifts" /id="U3212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.992007992007992" /xcortree=2273 /SigmaFactorBS="aatcaatccttttctgatattagTCTGGACTgtacagcacgc aTGTGGTCTTATAATAGTAAGgttaaaacatttttgttgtaattgcaacaaaaatacg t" /listShort="yybA, yybB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3684867..3684874) /Source="Nicolas_upshift_promotors" /id="U3212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.992007992007992" /xcortree=2273 /SigmaFactorBS="aatcaatccttttctgatattagTCTGGACTgtacagcacgc aTGTGGTCTTATAATAGTAAGgttaaaacatttttgttgtaattgcaacaaaaatacg t" /listShort="yybA, yybB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3684902..3685348 /gene="yyaT" /locus_tag="BSU_40720" /old_locus_tag="BSU40720" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase (polyamine degradation)" /protein_id="NP_391952.1" /db_xref="EnsemblGenomes-Gn:BSU40720" /db_xref="EnsemblGenomes-Tr:CAB16109" /db_xref="GOA:P37504" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10031" /db_xref="UniProtKB/Swiss-Prot:P37504" /translation="MNIKRITTEADLHEALKIRRGVFIEEQHVSEADEFDEFDTLQEQ CQHILVYHENQPVGTGRARIVGHTAKLERICILKPYRKYGLGKIIVSGLEEIMKEKGL TSYKLHGQTQAAGFYQKLGYQISSQEFMEDGIPHVLMTKEISRNIT*" /label="yyaT CDS" gene 3684902..3685348 /gene="yyaT" /locus_tag="BSU_40720" /old_locus_tag="BSU40720" /label="yyaT gene" CDS 3685345..3685950 /gene="yyaS" /locus_tag="BSU_40730" /old_locus_tag="BSU40730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23504016; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391953.1" /db_xref="EnsemblGenomes-Gn:BSU40730" /db_xref="EnsemblGenomes-Tr:CAB16110" /db_xref="SubtiList:BG10032" /db_xref="UniProtKB/Swiss-Prot:P37505" /translation="MKYMYYGIGILILSLGISLTIQSGLGTSPFDALLVGLSKKIGLT VGSWEVLISVILLICNAILTRKKPILLGLITAFITGIGIDLWLFVVKNTIYLNSLLSK LICFGIGLVLIGLGTAIYLQTKFASTPIDHLTLIIRDLSKRTILFSRTLVYALFLVLA IIFKGPIGIGTLLTVCLGGMLLHVFMPIVERHFLSKNRRGY*" /label="yyaS CDS" gene 3685345..3685950 /gene="yyaS" /locus_tag="BSU_40730" /old_locus_tag="BSU40730" /label="yyaS gene" CDS complement(3686045..3686566) /gene="yyaR" /locus_tag="BSU_40740" /old_locus_tag="BSU40740" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16579456, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyl-transferase" /protein_id="NP_391954.1" /db_xref="EnsemblGenomes-Gn:BSU40740" /db_xref="EnsemblGenomes-Tr:CAB16111" /db_xref="GOA:P37506" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR008125" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10033" /db_xref="UniProtKB/Swiss-Prot:P37506" /translation="MIMKMTHLNMKDFNKPNEPFVVFGRMIPAFENGVWTYTEERFSK PYFKQYEDDDMDVSYVEEEGKAAFLYYLENNCIGRIKIRSNWNGYALIEDIAVAKDYR KKGVGTALLHKAIEWAKENHFCGLMLETQDINISACHFYAKHHFIIGAVDTMLYSNFP TANEIAIFWYYKF*" /label="yyaR CDS" gene complement(3686045..3686566) /gene="yyaR" /locus_tag="BSU_40740" /old_locus_tag="BSU40740" /label="yyaR gene" S_feature complement(3686567..3687394) /Source="Nicolas_S_feature" /locus_tag="new_4185682_4186509_c" /HighExp="T0.30H, Lbstat, H2O2, LPhT, T1.0H, dia15, Diami, T1.30H, dia5, M9-stat" /AntisenseName="yyaQ" /AntisenseCor="0.51412050904654805" /AntisenseRegPval="-18.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1570" promotor_-35 3686615..3686622 /Source="Nicolas_upshift_promotors" /id="U3213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.955044955044955" /xcortree=607 /SigmaFactorBS="cgccaatcgagataatatttagtaaactcgtttcgatacTAT TCAACaacagcttccaaaaGTGTACTCTTTAAGAGAACAgcattagataaggcatcca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3686636 /Source="Nicolas_upshifts" /id="U3213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.955044955044955" /xcortree=607 /SigmaFactorBS="cgccaatcgagataatatttagtaaactcgtttcgatacTAT TCAACaacagcttccaaaaGTGTACTCTTTAAGAGAACAgcattagataaggcatcca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3686637..3686656 /Source="Nicolas_upshift_promotors" /id="U3213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.955044955044955" /xcortree=607 /SigmaFactorBS="cgccaatcgagataatatttagtaaactcgtttcgatacTAT TCAACaacagcttccaaaaGTGTACTCTTTAAGAGAACAgcattagataaggcatcca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3686702..3686976 /Source="Nicolas_S_feature" /locus_tag="new_4185817_4186091" /HighExp="LBGstat, G135, BC, G180, Sw, M9-stat, Diami, T0.30H, H2O2, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.13713" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1571" upshifts 3686702 /Source="Nicolas_upshifts" /id="U3214" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=2754 /SigmaFactorBS="ctctttaagagaacagcattagataaggcatccattacctta tatatttcactatcttaatgaGGTATTtcaacagaggctTGTGGTACAGTAAAAAGGA A" /listShort="S1571, yyaQ, S1572, yyaP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3686705..3686710 /Source="Nicolas_upshift_promotors" /id="U3214" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=2754 /SigmaFactorBS="ctctttaagagaacagcattagataaggcatccattacctta tatatttcactatcttaatgaGGTATTtcaacagaggctTGTGGTACAGTAAAAAGGA A" /listShort="S1571, yyaQ, S1572, yyaP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3686723..3686742 /Source="Nicolas_upshift_promotors" /id="U3214" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=2754 /SigmaFactorBS="ctctttaagagaacagcattagataaggcatccattacctta tatatttcactatcttaatgaGGTATTtcaacagaggctTGTGGTACAGTAAAAAGGA A" /listShort="S1571, yyaQ, S1572, yyaP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3686977..3687333 /gene="yyaQ" /locus_tag="BSU_40750" /old_locus_tag="BSU40750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391955.1" /db_xref="EnsemblGenomes-Gn:BSU40750" /db_xref="EnsemblGenomes-Tr:CAB16112" /db_xref="InterPro:IPR007351" /db_xref="SubtiList:BG10034" /db_xref="UniProtKB/Swiss-Prot:P37507" /translation="MLTREDIFKHVKEKYGTSPDYPWEKYPNYASLRHTSNKKWYGLI MNVLPEKLGLDGHGEIDILNLKCPPEISDRLRNGENILPGYHMDKEHWISIVLERTDP EGEIYNLIEQSFHLTK*" /label="yyaQ CDS" gene 3686977..3687333 /gene="yyaQ" /locus_tag="BSU_40750" /old_locus_tag="BSU40750" /label="yyaQ gene" S_feature 3687334..3687492 /Source="Nicolas_S_feature" /locus_tag="new_4186449_4186607" /HighExp="Sw, BC, G135, H2O2, LBGstat, G180, LPhT, T0.30H, Diami, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1572" promotor_-10 complement(3687376..3687395) /Source="Nicolas_upshift_promotors" /id="U3215" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.942057942057942" /psig="0.997002997002997" /xcortree=621 /SigmaFactorBS="cttctcccactctcgcaccagatgaactaagttgcgtTTGTG GACagagtgaagaacagTATCCTAAAATGAAAGTGCCcactactcttcgcagcttgat t" /listShort="S1570, yyaR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3687394) /Source="Nicolas_upshifts" /id="U3215" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.942057942057942" /psig="0.997002997002997" /xcortree=621 /SigmaFactorBS="cttctcccactctcgcaccagatgaactaagttgcgtTTGTG GACagagtgaagaacagTATCCTAAAATGAAAGTGCCcactactcttcgcagcttgat t" /listShort="S1570, yyaR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3687410..3687417) /Source="Nicolas_upshift_promotors" /id="U3215" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.942057942057942" /psig="0.997002997002997" /xcortree=621 /SigmaFactorBS="cttctcccactctcgcaccagatgaactaagttgcgtTTGTG GACagagtgaagaacagTATCCTAAAATGAAAGTGCCcactactcttcgcagcttgat t" /listShort="S1570, yyaR" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3687493..3688059 /gene="yyaP" /locus_tag="BSU_40760" /old_locus_tag="BSU40760" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391956.1" /db_xref="EnsemblGenomes-Gn:BSU40760" /db_xref="EnsemblGenomes-Tr:CAB16113" /db_xref="GOA:P37508" /db_xref="InterPro:IPR002734" /db_xref="InterPro:IPR024072" /db_xref="PDB:2GD9" /db_xref="SubtiList:BG10035" /db_xref="UniProtKB/Swiss-Prot:P37508" /translation="MTNNLKQRRIILDLAVTLDGFIEGKNGEVDWCIMDPDMGFTDFL NQIDTILYGRKSFDLWGQYIPKNEDPDTEKELWKLVHSKKKYVFSRTQNEIDNQAIFI NDNILEEVNKLKKNPGKDIWLYGGASLITTFINLGLVDEFRLSIHPVVLGEGKPLFID VKQRINLKMVNTRTFSSGVVQIVYHWNG*" /label="yyaP CDS" gene 3687493..3688059 /gene="yyaP" /locus_tag="BSU_40760" /old_locus_tag="BSU40760" /label="yyaP gene" CDS complement(3688566..3689942) /gene="tetB" /locus_tag="BSU_40770" /old_locus_tag="BSU40770" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7961647, 14636065, 15849754, 16850406, 17015648, 25954268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7961647, 14636065, 15849754, 16850406, 17015648, 25954268; Product type t : transporter" /codon_start=1 /transl_table=11 /product="multifunctional tetracycline-metal/H+ antiporterand Na+(K+)/H+ antiporter" /protein_id="NP_391957.1" /db_xref="EnsemblGenomes-Gn:BSU40770" /db_xref="EnsemblGenomes-Tr:CAB16114" /db_xref="GOA:P23054" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10036" /db_xref="UniProtKB/Swiss-Prot:P23054" /translation="MNTSYSQSTLRHNQVLIWLCVLSFFSVLNEMVLNVSLPDIANEF NKLPASANWVNTAFMLTFSIGTALYGKLSDQLGIKNLLLFGIMVNGLGSIIGFVGHSF FPILILARFIQGIGAAAFPALVMVVVARYIPKENRGKAFGLIGSLVAMGEGVGPAIGG MVAHYIHWSYLLLIPTATIITVPFLIKLLKKEERIRGHIDMAGIILMSAGIVFFMLFT TSYRFSFLIISILAFFIFVQHIRKAQDPFVDPELGKNVFFVIGTLCGGLIFGTVAGFV SMVPYMMKDVHHLSTAAIGSGIIFPGTMSVIIFGYIGGLLVDRKGSLYVLTIGSALLS SGFLIAAFFIDAAPWIMTIIVIFVFGGLSFTKTVISTVVSSSLKEKEAGAGMSLLNFT SFLSEGTGIAIVGGLLSIGFLDHRLLPIDVDHSTYLYSNMLILFAGIIVICWLVILNV YKRSRRHG*" /label="tetB CDS" gene complement(3688566..3689942) /gene="tetB" /locus_tag="BSU_40770" /old_locus_tag="BSU40770" /label="tetB gene" CDS complement(3689976..3690038) /gene="tetL" /locus_tag="BSU_40780" /old_locus_tag="BSU40780" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14636065, 17015648" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14636065, 17015648; Product type t: transporter" /codon_start=1 /transl_table=11 /product="tetracycline resistance leader peptide" /protein_id="NP_391958.1" /db_xref="EnsemblGenomes-Gn:BSU40780" /db_xref="EnsemblGenomes-Tr:CAB16115" /db_xref="GOA:P23053" /db_xref="InterPro:IPR012618" /db_xref="SubtiList:BG11051" /db_xref="UniProtKB/Swiss-Prot:P23053" /translation="MKCNKMNRVQLKEGSVSMTL*" /label="tetL CDS" gene complement(3689976..3690038) /gene="tetL" /locus_tag="BSU_40780" /old_locus_tag="BSU40780" /label="tetL gene" promotor_-10 complement(3690059..3690078) /Source="Nicolas_upshift_promotors" /id="U3216" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.635364635364635" /psig="0.998001998001998" /xcortree=2216 /SigmaFactorBS="ttgtttcgcaatctggtcaaatttttataaaaaaagtaaaAG TTTAATccttagtctataTATAATAAGATCATATCAATcaaatgtagggggagttatt a" /listShort="tetL, tetB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3690078) /Source="Nicolas_upshifts" /id="U3216" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.635364635364635" /psig="0.998001998001998" /xcortree=2216 /SigmaFactorBS="ttgtttcgcaatctggtcaaatttttataaaaaaagtaaaAG TTTAATccttagtctataTATAATAAGATCATATCAATcaaatgtagggggagttatt a" /listShort="tetL, tetB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3690091..3690098) /Source="Nicolas_upshift_promotors" /id="U3216" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.635364635364635" /psig="0.998001998001998" /xcortree=2216 /SigmaFactorBS="ttgtttcgcaatctggtcaaatttttataaaaaaagtaaaAG TTTAATccttagtctataTATAATAAGATCATATCAATcaaatgtagggggagttatt a" /listShort="tetL, tetB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3690226..3690232 /Source="Nicolas_upshift_promotors" /id="U3217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.998001998001998" /xcortree=618 /SigmaFactorBS="tttcacatcacaattatcgataagcagtcagtTATTGTAttt gtttaggataacTGTGGTAACCTGAATATAACcaacttaggaagaaggtgatcccatg c" /listShort="yyaO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3690248..3690267 /Source="Nicolas_upshift_promotors" /id="U3217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.998001998001998" /xcortree=618 /SigmaFactorBS="tttcacatcacaattatcgataagcagtcagtTATTGTAttt gtttaggataacTGTGGTAACCTGAATATAACcaacttaggaagaaggtgatcccatg c" /listShort="yyaO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3690254 /Source="Nicolas_upshifts" /id="U3217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.998001998001998" /xcortree=618 /SigmaFactorBS="tttcacatcacaattatcgataagcagtcagtTATTGTAttt gtttaggataacTGTGGTAACCTGAATATAACcaacttaggaagaaggtgatcccatg c" /listShort="yyaO" /GFF_Attribute="listLong" /label="upshifts" CDS 3690291..3690530 /gene="yyaO" /locus_tag="BSU_40790" /old_locus_tag="BSU40790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391959.1" /db_xref="EnsemblGenomes-Gn:BSU40790" /db_xref="EnsemblGenomes-Tr:CAB16116" /db_xref="InterPro:IPR004879" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10037" /db_xref="UniProtKB/Swiss-Prot:P37509" /translation="MPNKSKPNRLIAEKSPYLLQHAHNPVDWFPWGEEAFAKAKRENK PVLVSIGYSTTCHWWPGIIKSCGTPLKDNRSHFKR*" /label="yyaO CDS" gene 3690291..3690530 /gene="yyaO" /locus_tag="BSU_40790" /old_locus_tag="BSU40790" /label="yyaO gene" downshifts 3690539 /Source="Nicolas_upshifts" /id="D2115" /incds=0 /nref=7 /ntot=103 /MaxReadThrough="1.03879" /MaxDrop="3.89186" /score="10.758481" /energy="-8.2" /TU="NA" /idTUdmin="U3217" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 3690623..3690630 /Source="Nicolas_upshift_promotors" /id="U3218" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.994005994005994" /xcortree=1993 /SigmaFactorBS="gcggtagcaggtttttttattTGCTTGACttagagttaactc taAATTGTAAACTAACTTTAATtaaatgagagggatgatgttgttgtattccattagt a" /listShort="yyaN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3690646..3690665 /Source="Nicolas_upshift_promotors" /id="U3218" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.994005994005994" /xcortree=1993 /SigmaFactorBS="gcggtagcaggtttttttattTGCTTGACttagagttaactc taAATTGTAAACTAACTTTAATtaaatgagagggatgatgttgttgtattccattagt a" /listShort="yyaN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3690662 /Source="Nicolas_upshifts" /id="U3218" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.994005994005994" /xcortree=1993 /SigmaFactorBS="gcggtagcaggtttttttattTGCTTGACttagagttaactc taAATTGTAAACTAACTTTAATtaaatgagagggatgatgttgttgtattccattagt a" /listShort="yyaN" /GFF_Attribute="listLong" /label="upshifts" CDS 3690681..3691097 /gene="yyaN" /locus_tag="BSU_40800" /old_locus_tag="BSU40800" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11948146, 14663075; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MerR family)" /protein_id="NP_391960.1" /db_xref="EnsemblGenomes-Gn:BSU40800" /db_xref="EnsemblGenomes-Tr:CAB16117" /db_xref="GOA:P37510" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG10038" /db_xref="UniProtKB/Swiss-Prot:P37510" /translation="MLLYSISKAAEKTSISSYTLRYYEKIGLLPPPKRKNSGRRFYTE TDIQFMLFLKSLKETGMSLEDINEFVKDGCILEKINSDVKSAQLSPSINKRIEILTKH LEKMEIKKRELEEVISTTKGKLDTYYSILKEEVENK*" /label="yyaN CDS" gene 3690681..3691097 /gene="yyaN" /locus_tag="BSU_40800" /old_locus_tag="BSU40800" /label="yyaN gene" CDS 3691094..3692011 /gene="yyaM" /locus_tag="BSU_40810" /old_locus_tag="BSU40810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391961.1" /db_xref="EnsemblGenomes-Gn:BSU40810" /db_xref="EnsemblGenomes-Tr:CAB16118" /db_xref="GOA:P37511" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG10039" /db_xref="UniProtKB/Swiss-Prot:P37511" /translation="MKHLNIYIMLLGFSIFTGATFNLAKYTVGYFSPSSSAAWRFGLA AAVMLIILIFTEGIKKSQLRKNAVSYIVLGIIGIFGFNALFFVGLKYTSPVNGALIMG LNPLLTAILARIILKDNMTKKQVLGIFFAFIGVLLVITQGSIETIKTLSISGGDLIIF TGNVCWALYGVLGRRFVKDGTPLSTTTYTMVIGAVSLIVVSLFTSKPVSLSNIPIGVW GAIAFMAFFTSVLGYLWWNQGIKEIGASKTSLFFNLVPVVTMIISFAVGTPIKVFQVI GAVLVILGVLTASGVIRIPKYNTKEQSAI*" /label="yyaM CDS" gene 3691094..3692011 /gene="yyaM" /locus_tag="BSU_40810" /old_locus_tag="BSU40810" /label="yyaM gene" misc_feature 3692038..3692057 /Source="Nicolas_upshift_promotors" /id="U3219" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig="0.984015984015984" /xcortree=1462 /SigmaFactorBS="actaaagaacagtcagctatataaagaaatagggagtatttt tgagaaaaTGTGTTAAGTTAAATATACActaattataggaagaaggtgatcccatgcc a" /listShort="yyaL" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3692048 /Source="Nicolas_upshifts" /id="U3219" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig="0.984015984015984" /xcortree=1462 /SigmaFactorBS="actaaagaacagtcagctatataaagaaatagggagtatttt tgagaaaaTGTGTTAAGTTAAATATACActaattataggaagaaggtgatcccatgcc a" /listShort="yyaL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3692052..3692071) /Source="Nicolas_upshift_promotors" /id="U3220" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.978021978021978" /xcortree=3109 /SigmaFactorBS="attgattaatctattgggtttactttTGTTTGGCatgggatc accttCTTCCTATAATTAGTGTATAtttaacttaacacattttctcaaaaatactccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3692058) /Source="Nicolas_upshifts" /id="U3220" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.978021978021978" /xcortree=3109 /SigmaFactorBS="attgattaatctattgggtttactttTGTTTGGCatgggatc accttCTTCCTATAATTAGTGTATAtttaacttaacacattttctcaaaaatactccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 3692083..3694152 /gene="yyaL" /locus_tag="BSU_40820" /old_locus_tag="BSU40820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391962.1" /db_xref="EnsemblGenomes-Gn:BSU40820" /db_xref="EnsemblGenomes-Tr:CAB16119" /db_xref="GOA:P37512" /db_xref="InterPro:IPR004879" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR024705" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10040" /db_xref="UniProtKB/Swiss-Prot:P37512" /translation="MPNKSKPNRLINEKSPYLLQHAHNPVDWFPWGEEAFEKAKRENK PVLVSIGYSTCHWCHVMAHESFEDEEIARLLNERFVAIKVDREERPDVDSVYMRICQL MTGQGGWPLNVFITPDQKPFYAGTYFPKTSKFNRPGFVDVLEHLSETFANDREHVEDI AENAAKHLQTKTAAKTGEGLSESAIHRTFQQLASGFDTIYGGFGQAPKFPMPHMLMYL LRYDHNTGQENALYNVTKTLDSMANGGIYDHIGYGFARYSTDDEWLVPHFEKMLYDNA LLLTAYTEAYQVTQNSRYKEICEQIITFIQREMTHEDGSFFSALDADTEGEEGKYYVW SKEEILKTLGDDLGTLYCQVYDITEEGNFEGKNIPNLIHTKREQIKEDAGLTEKELSL KLEDARQQLLKTREERTYPHVDDKVLTSWNALMIAGLAKAAKVYQEPKYLSLAKDAIT FIENKLIIDGRVMVRYRDGEVKNKGFIDDYAFLLWAYLDLYEASFDLSYLQKAKKLTD DMISLFWDEEHGGFYFTGHDAEALIVREKEVYDGAVPSGNSVAAVQLLRLGQVTGDLS LIEKAETMFSVFKPDIEAYPSGHAFFMQSVLRHLMPKKEIVIFGSADDPARKQIIAEL QKAFKPNDSILVAEQPEQCKDIAPFAADYRIIDGKTTVYICENFACQQPTTNIEEAIH TLISSRD*" /label="yyaL CDS" gene 3692083..3694152 /gene="yyaL" /locus_tag="BSU_40820" /old_locus_tag="BSU40820" /label="yyaL gene" promotor_-35 complement(3692085..3692092) /Source="Nicolas_upshift_promotors" /id="U3220" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.978021978021978" /xcortree=3109 /SigmaFactorBS="attgattaatctattgggtttactttTGTTTGGCatgggatc accttCTTCCTATAATTAGTGTATAtttaacttaacacattttctcaaaaatactccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3694116 /Source="Nicolas_upshifts" /id="D2116" /incds=0 /nref=221 /ntot=260 /MaxReadThrough="1.24617" /MaxDrop="5.71843" /score="11.6894527" /energy="-16.6" /TU="NA" /idTUdmin="U3219" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3694149..3695048) /gene="yyaK" /locus_tag="BSU_40830" /old_locus_tag="BSU40830" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11343912, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protease" /protein_id="NP_391963.1" /db_xref="EnsemblGenomes-Gn:BSU40830" /db_xref="EnsemblGenomes-Tr:CAB16120" /db_xref="GOA:P37513" /db_xref="InterPro:IPR003675" /db_xref="SubtiList:BG10041" /db_xref="UniProtKB/Swiss-Prot:P37513" /translation="MNSFIRPIEGNNTLWRYFFAFLVMVGLYVLGNIAYLFAILFTVI VNPNITFDLDEAVLSDPLVDLYLSHVIYLFAIPGVWLAVRFILKRPFRTVITPNSKMN WRRISFGFIAYFLLMIAVQLIDFVIHPDSYSMQEFNASRFIWLLAAALILVPIQTSAE ELFFRGFLLQAFGRLTKNPLFLTLIVGGLFGVLHFANPEMNNGAVWAGIEYLTFGFVW TYYTIKTGSIEISLGAHAANNMFLCMFITEKNSVYGGIPSLFTVTRGNPMWEAFFTIA VNLVFAGIALWYHKKSKSKQQGS*" /label="yyaK CDS" gene complement(3694149..3695048) /gene="yyaK" /locus_tag="BSU_40830" /old_locus_tag="BSU40830" /label="yyaK gene" downshifts complement(3694192) /Source="Nicolas_upshifts" /id="D2117" /incds=0 /nref=65 /ntot=246 /MaxReadThrough="2.6155" /MaxDrop="3.91098" /score="23.2445146" /energy="-14.7" /TU="NA" /idTUdmin="U3221" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3695077..3695096) /Source="Nicolas_upshift_promotors" /id="U3221" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.839160839160839" /psig="0.98001998001998" /xcortree=2400 /SigmaFactorBS="ttatattttaattttgcttaaaagatttccaaaacAGTAGAT TcatagaccaatttaTGCAAATATATAGTAATATTctcattgaaaggaagagacatag a" /listShort="yyaK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3695093) /Source="Nicolas_upshifts" /id="U3221" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.839160839160839" /psig="0.98001998001998" /xcortree=2400 /SigmaFactorBS="ttatattttaattttgcttaaaagatttccaaaacAGTAGAT TcatagaccaatttaTGCAAATATATAGTAATATTctcattgaaaggaagagacatag a" /listShort="yyaK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3695095..3696326) /Source="Nicolas_S_feature" /locus_tag="new_4194210_4195441_c" /HighExp="S6, S8, S7, S5, B36, BT, S4, B60, S3, Diami" /AntisenseName="yyaJ" /AntisenseCor="-0.24400480530035801" /AntisenseRegPval="-4.3" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1573" promotor_-35 complement(3695111..3695118) /Source="Nicolas_upshift_promotors" /id="U3221" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.839160839160839" /psig="0.98001998001998" /xcortree=2400 /SigmaFactorBS="ttatattttaattttgcttaaaagatttccaaaacAGTAGAT TcatagaccaatttaTGCAAATATATAGTAATATTctcattgaaaggaagagacatag a" /listShort="yyaK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3695189..3695196 /Source="Nicolas_upshift_promotors" /id="U3222" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.725274725274725" /psig="0.978021978021978" /xcortree=3158 /SigmaFactorBS="tgtgaatttagttcttccatctagtgatttgaaCTCTGTTGc caatgaaccaagATACTTATAATAGTCCCAAGaggggaattttcagtcttttctacta c" /listShort="yyaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3695210..3695229 /Source="Nicolas_upshift_promotors" /id="U3222" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.725274725274725" /psig="0.978021978021978" /xcortree=3158 /SigmaFactorBS="tgtgaatttagttcttccatctagtgatttgaaCTCTGTTGc caatgaaccaagATACTTATAATAGTCCCAAGaggggaattttcagtcttttctacta c" /listShort="yyaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3695216 /Source="Nicolas_upshifts" /id="U3222" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.725274725274725" /psig="0.978021978021978" /xcortree=3158 /SigmaFactorBS="tgtgaatttagttcttccatctagtgatttgaaCTCTGTTGc caatgaaccaagATACTTATAATAGTCCCAAGaggggaattttcagtcttttctacta c" /listShort="yyaJ" /GFF_Attribute="listLong" /label="upshifts" CDS 3695274..3696629 /gene="yyaJ" /locus_tag="BSU_40840" /old_locus_tag="BSU40840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 9529885, 19087206, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391964.2" /db_xref="EnsemblGenomes-Gn:BSU40840" /db_xref="EnsemblGenomes-Tr:CAB16121" /db_xref="GOA:P37514" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10042" /db_xref="UniProtKB/Swiss-Prot:P37514" /translation="MNTIFKQKNTHPFSNAANRLDRLPISRVHFQVLTALGIVYFFDL ADLFTLSNVAPALIEHWGIPLSTIANVTAASFLGMFLGASLGGRLSDRIGRKKALNLF VFVFSIASLCNAAAWDIPSLMTFRFLTGFGVAAAMVITNSYLAEFFPSSVRGKYISFC AMIGLIGVPITNIVSAFVIPLGSWGWRLVFVWGAVGLIYFFFIHRLEESPRWHENRGE YAKADAILTRIEEQVEKEKGPLPAASQPKVSETVKQNAGYAGLLKGRNLKITIVLSAV WIFETFGFYGFASWVPSLLKSNGVTMENTLWYNVLHSVGAPLGALLGSMISERFQRKW ILAASAFLTAIAGLLYGMTFIPIMIIVFGFIVNITERVFTSNLYAYTSEPYPTEYRSS GSGLAYGLGRFSNIFGSLLVGFIAVQLGYISVFLFIGGCWLACSLLLIFFGPNTNAKQ I*" /label="yyaJ CDS" gene 3695274..3696629 /gene="yyaJ" /locus_tag="BSU_40840" /old_locus_tag="BSU40840" /label="yyaJ gene" promotor_-10 complement(3696312..3696331) /Source="Nicolas_upshift_promotors" /id="U3223" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1260 /SigmaFactorBS="aggtaaagacccgttctgtgatattcacgataaaaccaaata CAATGATCATgatgggaataaaaGTCATACCATATAAGAGCCCggcgatggccgtcag a" /listShort="S1573, yyaK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3696336) /Source="Nicolas_upshifts" /id="U3223" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1260 /SigmaFactorBS="aggtaaagacccgttctgtgatattcacgataaaaccaaata CAATGATCATgatgggaataaaaGTCATACCATATAAGAGCCCggcgatggccgtcag a" /listShort="S1573, yyaK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3696345..3696354) /Source="Nicolas_upshift_promotors" /id="U3223" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1260 /SigmaFactorBS="aggtaaagacccgttctgtgatattcacgataaaaccaaata CAATGATCATgatgggaataaaaGTCATACCATATAAGAGCCCggcgatggccgtcag a" /listShort="S1573, yyaK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3696663..3697217) /gene="maa" /locus_tag="BSU_40850" /old_locus_tag="BSU40850" /EC_number="2.3.1.79" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12731863, 12793527, 19087206, 22226636, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maltose O-acetyltransferase" /protein_id="NP_391965.1" /db_xref="EnsemblGenomes-Gn:BSU40850" /db_xref="EnsemblGenomes-Tr:CAB16122" /db_xref="GOA:P37515" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR024688" /db_xref="SubtiList:BG10043" /db_xref="UniProtKB/Swiss-Prot:P37515" /translation="MLRTEKEKMAAGELYNSEDQQLLLERKHARQLIRQYNETPEDDA VRTKLLKELLGSVGDQVTILPTFRCDYGYHIHIGDHTFVNFDCVILDVCEVRIGCHCL IAPGVHIYTAGHPLDPIERKSGKEFGKPVTIGDQVWIGGRAVINPGVTIGDNAVIASG SVVTKDVPANTVVGGNPARILKQL*" /label="maa CDS" gene complement(3696663..3697217) /gene="maa" /locus_tag="BSU_40850" /old_locus_tag="BSU40850" /label="maa gene" CDS complement(3697235..3697615) /gene="yyaH" /locus_tag="BSU_40860" /old_locus_tag="BSU40860" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19087206; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative C-S lyase" /protein_id="NP_391966.1" /db_xref="EnsemblGenomes-Gn:BSU40860" /db_xref="EnsemblGenomes-Tr:CAB16123" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG10044" /db_xref="UniProtKB/Swiss-Prot:P37516" /translation="MQIEHTAVWVNDLERMKSFYESYFNGEANDLYHNEKKDFKSYFI TFDSGARLEIMKKGNVTDPPSQTMTGWAHIAFSVGSREKVDELTDRLKADGFAVVNGP RTTGDGYYESVIEDDEGNLIEITI*" /label="yyaH CDS" gene complement(3697235..3697615) /gene="yyaH" /locus_tag="BSU_40860" /old_locus_tag="BSU40860" /label="yyaH gene" CDS complement(3697671..3698606) /gene="ccpB" /locus_tag="BSU_40870" /old_locus_tag="BSU40870" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9457849, 9642180, 16267306" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9457849, 9642180, 16267306; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of carbon supply (LacIfamily)" /protein_id="NP_391967.1" /db_xref="EnsemblGenomes-Gn:BSU40870" /db_xref="EnsemblGenomes-Tr:CAB16124" /db_xref="GOA:P37517" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR001761" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10045" /db_xref="UniProtKB/Swiss-Prot:P37517" /translation="MANIKEIARLANVSVSTVSRVLNHHPYVSEEKRKLVHQVMKELD YTPNRTAIDLIRGKTHTVGVILPYSDHPCFDKIVNGITKAAFQHEYATTLLPTNYNPD IEIKYLELLRTKKIDGLIITSRANHWDSILAYQEYGPVIACEDTGDIDVPCAFNDRKT AYAESFRYLKSRGHENIAFTCVREADRSPSTADKAAAYKAVCGRLEDRHMLSGCNDMN DGELAAEHFYMSGRVPTAIYANSDEVAAGIHLFAKKNNWDVEIIGEGNTSISRVLGFP SLDLNLEQLGIAAFSLFLQDEPADIKIQHKFKKKA*" /label="ccpB CDS" gene complement(3697671..3698606) /gene="ccpB" /locus_tag="BSU_40870" /old_locus_tag="BSU40870" /label="ccpB gene" promotor_-35 3698596..3698605 /Source="Nicolas_upshift_promotors" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3698619..3698638 /Source="Nicolas_upshift_promotors" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3698626 /Source="Nicolas_upshifts" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3698650..3698669) /Source="Nicolas_upshift_promotors" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3698664) /Source="Nicolas_upshifts" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3698665..3699423) /gene="exoA" /locus_tag="BSU_40880" /old_locus_tag="BSU40880" /EC_number="3.1.11.2" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10540738, 16237020, 18203828, 21441501, 24244006, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10540738, 16237020, 18203828, 21441501, 24244006, 24914186; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="apurinic/apyrimidinic endonuclease" /protein_id="NP_391968.1" /db_xref="EnsemblGenomes-Gn:BSU40880" /db_xref="EnsemblGenomes-Tr:CAB16125" /db_xref="GOA:P37454" /db_xref="InterPro:IPR004808" /db_xref="InterPro:IPR005135" /db_xref="InterPro:IPR020847" /db_xref="InterPro:IPR020848" /db_xref="InterPro:IPR036691" /db_xref="PDB:5CFE" /db_xref="SubtiList:BG10046" /db_xref="UniProtKB/Swiss-Prot:P37454" /translation="MKLISWNVNGLRAVMRKMDFLSYLKEEDADIICLQETKIQDGQV DLQPEDYHVYWNYAVKKGYSGTAVFSKQEPLQVIYGIGVEEHDQEGRVITLEFENVFV MTVYTPNSRRGLERIDYRMQWEEALLSYILELDQKKPVILCGDLNVAHQEIDLKNPKA NRNNAGFSDQEREAFTRFLEAGFVDSFRHVYPDLEGAYSWWSYRAGARDRNIGWRIDY FVVSESLKEQIEDASISADVMGSDHCPVELIINI*" /label="exoA CDS" gene complement(3698665..3699423) /gene="exoA" /locus_tag="BSU_40880" /old_locus_tag="BSU40880" /label="exoA gene" promotor_-35 complement(3698682..3698689) /Source="Nicolas_upshift_promotors" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3698956..3699459 /Source="Nicolas_S_feature" /locus_tag="new_4198071_4198574" /HighExp="C30, S8, S7, S6, BT, S5, M/G, Glucon, C90, T1.0H" /AntisenseName="exoAA" /AntisenseCor="-0.177921457862244" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1574" downshifts 3699418 /Source="Nicolas_upshifts" /id="D2118" /incds=0 /nref=2 /ntot=12 /MaxReadThrough="2.65789" /MaxDrop="4.11352" /score="16.4680636" /energy="-6.8" /TU="NA" /idTUdmin="U3224" /TUdmin=528 /isTUend="FALSE" /label="downshifts" CDS complement(3699488..3699727) /gene="rpsR" /locus_tag="BSU_40890" /old_locus_tag="BSU40890" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 22720735, 24310371" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 22720735, 24310371; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S18" /protein_id="NP_391969.2" /db_xref="EnsemblGenomes-Gn:BSU40890" /db_xref="EnsemblGenomes-Tr:CAB16126" /db_xref="GOA:P21475" /db_xref="InterPro:IPR001648" /db_xref="InterPro:IPR018275" /db_xref="InterPro:IPR036870" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10047" /db_xref="UniProtKB/Swiss-Prot:P21475" /translation="MAGGRRGGRAKRRKVCYFTSNGITHIDYKDVDLLKKFVSERGKI LPRRVTGTNAKYQRKLTAAIKRARQMALLPYVSGE*" /label="rpsR CDS" gene complement(3699488..3699727) /gene="rpsR" /locus_tag="BSU_40890" /old_locus_tag="BSU40890" /label="rpsR gene" downshifts complement(3699494) /Source="Nicolas_upshifts" /id="D2119" /incds=0 /nref=217 /ntot=268 /MaxReadThrough="4.97781" /MaxDrop="7.46952" /score="21.7622917" /energy="-15.3" /TU="U3226,U3227" /idTUdmin="U3229" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3699562) /Source="Nicolas_upshifts" /id="D2120" /incds=1 /nref=13 /ntot=142 /MaxReadThrough="8.89363" /MaxDrop="3.9797" /score="21.7622917" /energy="-15.3" /TU="U3226,U3227,U3229" /idTUdmin="U3229" /TUdmin="-68" /isTUend="FALSE" /label="downshifts" CDS complement(3699771..3700289) /gene="ssbA" /locus_tag="BSU_40900" /old_locus_tag="BSU40900" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 16549871, 10072765, 25138221, 26001966, 28575448" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 16549871, 10072765, 25138221, 26001966, 28575448; Product type f: factor" /codon_start=1 /transl_table=11 /product="single-strand DNA-binding protein" /protein_id="NP_391970.1" /db_xref="EnsemblGenomes-Gn:BSU40900" /db_xref="EnsemblGenomes-Tr:CAB16127" /db_xref="GOA:P37455" /db_xref="InterPro:IPR000424" /db_xref="InterPro:IPR011344" /db_xref="InterPro:IPR012340" /db_xref="SubtiList:BG10048" /db_xref="UniProtKB/Swiss-Prot:P37455" /translation="MLNRVVLVGRLTKDPELRYTPNGAAVATFTLAVNRTFTNQSGER EADFINCVTWRRQAENVANFLKKGSLAGVDGRLQTRNYENQQGQRVFVTEVQAESVQF LEPKNGGGSGSGGYNEGNSGGGQYFGGGQNDNPFGGNQNNQRRNQGNSFNDDPFANDG KPIDISDDDLPF*" /label="ssbA CDS" gene complement(3699771..3700289) /gene="ssbA" /locus_tag="BSU_40900" /old_locus_tag="BSU40900" /label="ssbA gene" CDS complement(3700330..3700617) /gene="rpsF" /locus_tag="BSU_40910" /old_locus_tag="BSU40910" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 19653700, 26447183" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 19653700, 26447183; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S6 (BS9)" /protein_id="NP_391971.1" /db_xref="EnsemblGenomes-Gn:BSU40910" /db_xref="EnsemblGenomes-Tr:CAB16128" /db_xref="GOA:P21468" /db_xref="InterPro:IPR000529" /db_xref="InterPro:IPR014717" /db_xref="InterPro:IPR020814" /db_xref="InterPro:IPR020815" /db_xref="InterPro:IPR035980" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10049" /db_xref="UniProtKB/Swiss-Prot:P21468" /translation="MRKYEVMYIIRPNIDEESKKAVIERFNNVLTSNGAEITGTKDWG KRRLAYEINDFRDGFYQIVNVQSDAAAVQEFDRLAKISDDIIRHIVVKEEE*" /label="rpsF CDS" gene complement(3700330..3700617) /gene="rpsF" /locus_tag="BSU_40910" /old_locus_tag="BSU40910" /label="rpsF gene" S_feature complement(3700618..3700684) /Source="Nicolas_S_feature" /locus_tag="new_4199733_4199799_c" /HighExp="MG t5, LPhT, GM 90, SMM, T-5.40H, GM-0.2, MG 150, GM 45, Gly, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.993, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1575" promotor_-10 complement(3700683..3700702) /Source="Nicolas_upshift_promotors" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3700684) /Source="Nicolas_upshifts" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3700716..3700721) /Source="Nicolas_upshift_promotors" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3700728..3701828) /gene="engD" /locus_tag="BSU_40920" /old_locus_tag="BSU40920" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12837776, 16014871, 18713637, 21527254, 22995830, 26018081, 26160547, 26912459; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="potassium-dependent informational ATPase interacting with 70S ribosome; ROS stress regulator" /protein_id="NP_391972.1" /db_xref="EnsemblGenomes-Gn:BSU40920" /db_xref="EnsemblGenomes-Tr:CAB16129" /db_xref="GOA:P37518" /db_xref="InterPro:IPR004396" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR013029" /db_xref="InterPro:IPR023192" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031167" /db_xref="SubtiList:BG10050" /db_xref="UniProtKB/Swiss-Prot:P37518" /translation="MALTAGIVGLPNVGKSTLFNAITQAGAESANYPFCTIDPNVGIV EVPDDRLQKLTELVNPKKTVPTAFEFTDIAGIVKGASKGEGLGNKFLSHIRQVDAICH VVRAFSDDNITHVSGKVDPIDDIETINLELILADMETVEKRITRVSKLAKQKDKDAVF EFEILSKLKEAFESEKPARSVEFTEEQQKLVKQLHLLTSKPILYVANVSEDEVADPSG NENVAKIREYAAGENAEVIVVCAKIESEIAELEGEEKQMFLEELGIQESGLDQLIKAS YSLLGLATYFTAGEQEVRAWTFKKGMKAPECAGIIHSDFERGFIRAETVAYEDLLAGG GMAGAKEAGKVRLEGKEYVVQDGDVIHFRFNV*" /label="engD CDS" gene complement(3700728..3701828) /gene="engD" /locus_tag="BSU_40920" /old_locus_tag="BSU40920" /label="engD gene" promotor_-10 complement(3701876..3701895) /Source="Nicolas_upshift_promotors" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="promotor_-10" upshifts complement(3701891) /Source="Nicolas_upshifts" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="upshifts" promotor_-35 complement(3701910..3701917) /Source="Nicolas_upshift_promotors" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="promotor_-35" CDS complement(3701955..3703958) /gene="yyaE" /locus_tag="BSU_40930" /old_locus_tag="BSU40930" /EC_number="1.-.-.-" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17114254, 20817769; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (molybdoenzyme)" /protein_id="NP_391973.1" /db_xref="EnsemblGenomes-Gn:BSU40930" /db_xref="EnsemblGenomes-Tr:CAB16130" /db_xref="GOA:P37519" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG10051" /db_xref="UniProtKB/Swiss-Prot:P37519" /translation="MSKVHQSACPLNCWDSCGFLVTVDDGKVTKVDGDPNHPITEGKI CGRGRMLETKTNSPDRLRYPMKKQNGEFVRISWEQALDEIADKLREIKETSETTAVLH SHDYANNGLLKALDQRFFNGYGGVTEIVGSICWGSGIEAQSWDFGRSYGHGPLDIYNS KHVVVWGRNVSRTNMHLYHHLQQVKKKGATITVIDPIFNPTAKLADRYISVKPGMDGW LAAAVLKVLIEMGRTDETFISEHSVGFDDVKELLKTVSLEEFIVKTETSMEELEYLAG LYADGPVSTFMGLGMQRYKNGGGTIRWIDALVAASGNVGIKGGGANFGNVQIGESFAK TKLTLPELKTTSRSFSMMTQAEEVLTAADPAIEMIIVTCGNPLTQVPNTNKVRQAFEK VPMTVAIDSIMTDTAELCDYVLPTATVFEEEDIYYSSMYHHYVQYGKKLVEPQGEAKS DSWIWSELAKRLGFGELFEYSTQEFLEMGLSSLEAEDVTLERLKEKGHLPLPVKQVPW DDYQFLTPSGKFEFTSSLAEQKGFSGSLQLNVPEESVFHNEELAGKYPYTLLSIHPQR SNHSQHVPFIEKLQHVQVDISPDIAAGQDLQDGDEVVIFNDRGSMKGKVKVMKQAHAK TINIDEGMWAAFGGSVNALTNDTNSDNGMGSTLFDCLVGLKKA*" /label="yyaE CDS" gene complement(3701955..3703958) /gene="yyaE" /locus_tag="BSU_40930" /old_locus_tag="BSU40930" /label="yyaE gene" CDS complement(3704009..3704215) /gene="yyzM" /locus_tag="BSU_40939" /old_locus_tag="BSU40939" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21348639, 22333191, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="YP_003097803.1" /db_xref="EnsemblGenomes-Gn:BSU40939" /db_xref="EnsemblGenomes-Tr:CAX52723" /db_xref="InterPro:IPR009296" /db_xref="UniProtKB/Swiss-Prot:C0H3V8" /translation="MADKDFGLNDIVEMKKPHPCGANSWKIIRMGMDIRIKCEGCSHS VMIPRREFERKLKKVLVKHEEPTS*" /label="yyzM CDS" gene complement(3704009..3704215) /gene="yyzM" /locus_tag="BSU_40939" /old_locus_tag="BSU40939" /label="yyzM gene" promotor_-10 complement(3704177..3704196) /Source="Nicolas_upshift_promotors" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3704202) /Source="Nicolas_upshifts" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3704211..3704217) /Source="Nicolas_upshift_promotors" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3704241..3704260) /Source="Nicolas_upshift_promotors" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="promotor_-10" upshifts complement(3704252) /Source="Nicolas_upshifts" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="upshifts" promotor_-35 complement(3704277..3704281) /Source="Nicolas_upshift_promotors" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="promotor_-35" CDS complement(3704309..3705325) /gene="yyaD" /locus_tag="BSU_40940" /old_locus_tag="BSU40940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16847258, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391974.1" /db_xref="EnsemblGenomes-Gn:BSU40940" /db_xref="EnsemblGenomes-Tr:CAB16131" /db_xref="SubtiList:BG10052" /db_xref="UniProtKB/Swiss-Prot:P37520" /translation="MLWRAGMKWMLLILGSLIGAGYASGQEIWQFFGAESGLAIVLFT IMFIFSSYIVMKISFKVQSTHFLPVLEHLMGPWLAKIYDVLIIFYLFSTTMVMIAGGG VTLQMYKLPFWWGITLICIVTVCLFLWDVKGILSINSILIPVLVAGLLYALISFQSTH HHTWTIDLSQQYNWPASITFTSLNILSVVAILSSVGKEMKGLGEAKIASVASGLIFGV ISFVYNETLVELAGSLSQFEIPLFAVLEGAPYFLFLCMTAVLCLAIYTTTVAGLLGLS SRLMAFIHMPRWMIVLILLVLMVPFTSFGFSDLIAFLYPIYGMLNLYLLVCLLLYPIL SKWK*" /label="yyaD CDS" gene complement(3704309..3705325) /gene="yyaD" /locus_tag="BSU_40940" /old_locus_tag="BSU40940" /label="yyaD gene" promotor_-10 complement(3705358..3705376) /Source="Nicolas_upshift_promotors" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3705370) /Source="Nicolas_upshifts" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3705392..3705397) /Source="Nicolas_upshift_promotors" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3705501) /Source="Nicolas_upshifts" /id="D2121" /incds=0 /nref=32 /ntot=184 /MaxReadThrough="1.8976" /MaxDrop="3.72136" /score="9.09987016" /energy="-7.4" /TU="NA" /idTUdmin="U3230" /TUdmin="-397" /isTUend="FALSE" /label="downshifts" promotor_-35 3705685..3705690 /Source="Nicolas_upshift_promotors" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3705703..3705784 /Source="Nicolas_S_feature" /locus_tag="new_4204818_4204899" /HighExp="S4, S5, S3, S6, LoTm, S7, T5.0H, BT, M9-stat, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1576" upshifts 3705703 /Source="Nicolas_upshifts" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3705706..3705724 /Source="Nicolas_upshift_promotors" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3705785..3706402 /gene="sprC" /locus_tag="BSU_40950" /old_locus_tag="BSU40950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 26362088; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="spore-specific protease" /protein_id="NP_391975.1" /db_xref="EnsemblGenomes-Gn:BSU40950" /db_xref="EnsemblGenomes-Tr:CAB16132" /db_xref="InterPro:IPR009665" /db_xref="InterPro:IPR023430" /db_xref="SubtiList:BG10053" /db_xref="UniProtKB/Swiss-Prot:P37521" /translation="MNRKGGLFSSQERVKQYVSHTDAAAAKQIQTILSSSLRKAAGKP IVVVCIGTDRSTGDSLGPLVGMKLKQMQLTRFHVYGTLSDPVHAVNMKDKINDIHKLH KNPFVIAVDACLGRVKSVGSFQIGDGPLKPGAGVQKDLPEVGDLHINGIVNVSGFMEY FVLQNTRLNLVMNMANVLAEGLSLTDRTEWRQERLNPLQRLTGRI*" /label="sprC CDS" gene 3705785..3706402 /gene="sprC" /locus_tag="BSU_40950" /old_locus_tag="BSU40950" /label="sprC gene" promotor_-35 3706373..3706381 /Source="Nicolas_upshift_promotors" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3706392 /Source="Nicolas_upshifts" /id="D2122" /incds=0 /nref=11 /ntot=30 /MaxReadThrough="2.64888" /MaxDrop="3.74502" /score="0.352922387" /energy="-6.6" /TU="NA" /idTUdmin="U3231" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 3706395..3706413 /Source="Nicolas_upshift_promotors" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3706414 /Source="Nicolas_upshifts" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3706441..3707289) /gene="parB" /locus_tag="BSU_40960" /old_locus_tag="BSU40960" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 21235642, 28407103" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 21235642, 28407103; Product type f: factor" /codon_start=1 /transl_table=11 /product="site-specific DNA-binding protein" /protein_id="NP_391976.1" /db_xref="EnsemblGenomes-Gn:BSU40960" /db_xref="EnsemblGenomes-Tr:CAB16133" /db_xref="GOA:P26497" /db_xref="InterPro:IPR003115" /db_xref="InterPro:IPR004437" /db_xref="InterPro:IPR036086" /db_xref="SubtiList:BG10054" /db_xref="UniProtKB/Swiss-Prot:P26497" /translation="MAKGLGKGINALFNQVDLSEETVEEIKIADLRPNPYQPRKHFDD EALAELKESVLQHGILQPLIVRKSLKGYDIVAGERRFRAAKLAGLDTVPAIVRELSEA LMREIALLENLQREDLSPLEEAQAYDSLLKHLDLTQEQLAKRLGKSRPHIANHLRLLT LPENIQQLIAEGTLSMGHGRTLLGLKNKNKLEPLVQKVIAEQLNVRQLEQLIQQLNQN VPRETKKKEPVKDAVLKERESYLQNYFGTTVNIKRQKKKGKIEIEFFSNEDLDRILEL LSERES*" /label="parB CDS" gene complement(3706441..3707289) /gene="parB" /locus_tag="BSU_40960" /old_locus_tag="BSU40960" /label="parB gene" downshifts complement(3706461) /Source="Nicolas_upshifts" /id="D2123" /incds=0 /nref=208 /ntot=265 /MaxReadThrough="3.01094" /MaxDrop="5.3801" /score="9.82080496" /energy="-7.9" /TU="U3233" /idTUdmin="U3233" /TUdmin="-257" /isTUend="FALSE" /label="downshifts" CDS complement(3707282..3708043) /gene="parA" /locus_tag="BSU_40970" /old_locus_tag="BSU40970" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 18077387, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 18077387, 28166228; Product type f: factor" /codon_start=1 /transl_table=11 /product="chromosome partitioning protein; transcriptionalregulator" /protein_id="NP_391977.1" /db_xref="EnsemblGenomes-Gn:BSU40970" /db_xref="EnsemblGenomes-Tr:CAB16134" /db_xref="GOA:P37522" /db_xref="InterPro:IPR025669" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10055" /db_xref="UniProtKB/Swiss-Prot:P37522" /translation="MGKIIAITNQKGGVGKTTTSVNLGACLAYIGKRVLLVDIDPQGN ATSGLGIEKADVEQCVYDILVDDADVIDIIKATTVENLDVIPATIQLAGAEIELVPTI SREVRLKRALEAVKQNYDYIIIDCPPSLGLLTINALTASDSVVIPVQCEYYALEGLSQ LLNTVRLVQKHLNTDLMIEGVLLTMLDARTNLGIQVIEEVKKYFRDKVYKTVIPRNVR LSEAPSHGKPIILYDPRSRGAEVYLDLAKEVAANG*" /label="parA CDS" gene complement(3707282..3708043) /gene="parA" /locus_tag="BSU_40970" /old_locus_tag="BSU40970" /label="parA gene" misc_feature complement(3708077..3708096) /Source="Nicolas_upshift_promotors" /id="U3233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2325 /SigmaFactorBS="attatttcccttctgattcggaacaaaatgatgaaaaaaatg aaacgctttaatcttttTTTGATAGAATAGAAGCAAGatagtacatgttcatgtgaaa g" /listShort="parA, parB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3708095) /Source="Nicolas_upshifts" /id="U3233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2325 /SigmaFactorBS="attatttcccttctgattcggaacaaaatgatgaaaaaaatg aaacgctttaatcttttTTTGATAGAATAGAAGCAAGatagtacatgttcatgtgaaa g" /listShort="parA, parB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3708187) /Source="Nicolas_upshifts" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="upshifts" promotor_-10 complement(3708190..3708198) /Source="Nicolas_upshift_promotors" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="promotor_-10" promotor_-35 complement(3708212..3708220) /Source="Nicolas_upshift_promotors" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="promotor_-35" promotor_-35 3708224..3708232 /Source="Nicolas_upshift_promotors" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3708240 /Source="Nicolas_upshifts" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3708244..3708262 /Source="Nicolas_upshift_promotors" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3708291..3708731 /gene="yyaB" /locus_tag="BSU_40980" /old_locus_tag="BSU40980" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25651892; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative antibiotic immunity protein" /protein_id="NP_391978.2" /db_xref="EnsemblGenomes-Gn:BSU40980" /db_xref="EnsemblGenomes-Tr:CAB16135" /db_xref="GOA:P37523" /db_xref="InterPro:IPR009589" /db_xref="SubtiList:BG10056" /db_xref="UniProtKB/Swiss-Prot:P37523" /translation="MVYQTKRDVPVTLMIVFLILLIQADAIVPFVLGNMRVSGWIIFI LLTLLNGLIIWSFIDLKYVLKEHHLIIKAGLIKHQIPYENIDKVVQKKKLWSGFRLIG SRHAITIYYQGGWGHAVISPQKSEEFIHKLKEKNSNIIIFTKSK*" /label="yyaB CDS" gene 3708291..3708731 /gene="yyaB" /locus_tag="BSU_40980" /old_locus_tag="BSU40980" /label="yyaB gene" downshifts 3708680 /Source="Nicolas_upshifts" /id="D2124" /incds=0 /nref=3 /ntot=144 /MaxReadThrough="2.25356" /MaxDrop="3.41185" /score="-0.6683508" /energy="-14.5" /TU="NA" /idTUdmin="U3235" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3708782..3709633) /gene="nocA" /locus_tag="BSU_40990" /old_locus_tag="BSU40990" /function="16.13: Shape" /function="16.8: Protect" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11807071, 15210112, 16549676, 25568309, 28500529" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11807071, 15210112, 16549676, 25568309, 28500529; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA-binding protein Spo0J-like" /protein_id="NP_391979.1" /db_xref="EnsemblGenomes-Gn:BSU40990" /db_xref="EnsemblGenomes-Tr:CAB16136" /db_xref="GOA:P37524" /db_xref="InterPro:IPR003115" /db_xref="InterPro:IPR004437" /db_xref="InterPro:IPR023705" /db_xref="InterPro:IPR036086" /db_xref="SubtiList:BG10057" /db_xref="UniProtKB/Swiss-Prot:P37524" /translation="MKHSFSRFFGLGEKEQEPEIAEHDTNKEEILEIPVNAIVPNRFQ PRTIFSDEKIKELAMTIHTHGIIQPIVVRHTEEEGQYELIAGERRWRAVQSLEWEKIP AIIKDFSDTETASVALIENLQREELSSIEEAHAYARLLELHDLTQEALAQRLGKGQST IANKLRLLKLPQPVQEAIMEKKITERHARALIPLKQPELQVTLLTEIIEKSLNVKQTE DRVVKMLEQGQRKPKPRRKAFSRDTRIAMNTIRQSLSMVEDSGVKLNTEEEEFEEYIQ LTIRIPK*" /label="nocA CDS" gene complement(3708782..3709633) /gene="nocA" /locus_tag="BSU_40990" /old_locus_tag="BSU40990" /label="nocA gene" downshifts complement(3708801) /Source="Nicolas_upshifts" /id="D2125" /incds=0 /nref=245 /ntot=265 /MaxReadThrough="2.30868" /MaxDrop="6.68899" /score="29.5496038" /energy="-14.5" /TU="NA" /idTUdmin="U3236" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature complement(3709634..3709754) /Source="Nicolas_S_feature" /locus_tag="new_4208749_4208869_c" /HighExp="LBGstat, G135, G180, H2O2, dia15, G150, Paraq, T0.30H, Oxctl, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1577" CDS complement(3709755..3710474) /gene="rsmG" /locus_tag="BSU_41000" /old_locus_tag="BSU41000" /EC_number="2.1.1.170" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12001236, 17238915, 17573471, 19622680, 24509311" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12001236, 17238915, 17573471, 19622680, 24509311; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="7-methylguanosine methyltransferase (16S rRNA, nucleotide G527)" /protein_id="NP_391980.1" /db_xref="EnsemblGenomes-Gn:BSU41000" /db_xref="EnsemblGenomes-Tr:CAB16137" /db_xref="GOA:P25813" /db_xref="InterPro:IPR003682" /db_xref="InterPro:IPR029063" /db_xref="PDB:1XDZ" /db_xref="SubtiList:BG10058" /db_xref="UniProtKB/Swiss-Prot:P25813" /translation="MNIEEFTSGLAEKGISLSPRQLEQFELYYDMLVEWNEKINLTSI TEKKEVYLKHFYDSITAAFYVDFNQVNTICDVGAGAGFPSLPIKICFPHLHVTIVDSL NKRITFLEKLSEALQLENTTFCHDRAETFGQRKDVRESYDIVTARAVARLSVLSELCL PLVKKNGLFVALKAASAEEELNAGKKAITTLGGELENIHSFKLPIEESDRNIMVIRKI KNTPKKYPRKPGTPNKSPIEG*" /label="rsmG CDS" gene complement(3709755..3710474) /gene="rsmG" /locus_tag="BSU_41000" /old_locus_tag="BSU41000" /label="rsmG gene" CDS complement(3710488..3712374) /gene="trmF" /locus_tag="BSU_41010" /old_locus_tag="BSU41010" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11914360, 14993678, 17062623, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA uridine 5-carboxymethylaminomethyl modification enzyme" /protein_id="NP_391981.1" /db_xref="EnsemblGenomes-Gn:BSU41010" /db_xref="EnsemblGenomes-Tr:CAB16138" /db_xref="GOA:P25812" /db_xref="InterPro:IPR002218" /db_xref="InterPro:IPR004416" /db_xref="InterPro:IPR020595" /db_xref="InterPro:IPR026904" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10059" /db_xref="UniProtKB/Swiss-Prot:P25812" /translation="MGYEAGQYDVIVIGAGHAGVEAALASARQGAKTLVLTINLDMVA FMPCNPSVGGPAKGIVVREIDALGGEMGRNIDKTHIQMRMLNTGKGPAVRALRAQADK FQYQHEMKNTLEKEPNLTLLQGIVERLIVEDGECRGVITQTGAHYRAKAVVMTTGTYL RGRIILGDLSYSSGPNNQQPSIKLSEHLEELGFDLVRFKTGTPPRVKSDTIDYSKTEI QPGDDVPRAFSYETVEYITDQLPCWLTYTSPETHEIIDSNLHRSPMYSGMIKGTGPRY CPSIEDKVVRFNDKPRHQIFLEPEGRNTQEVYVQGLSTSLPEDVQQRMLATIPGLENV QMMRAGYAIEYDAIVPTQLWPTLETKKITNLYTAGQINGTSGYEEAAGQGIMAGINAG RKALGKEEVILSRSDAYIGVLIDDLVTKGTNEPYRLLTSRAEYRLLLRHDNADLRLTE IGHRIGLISDERYAAFEKKKAAIEAEKKRLHSVIIKPSPENQEYIRSLGGSELKDGVR GTDLMKRPEMNYETVTKLAPPEVPVPQDVAEQVEIQVKYEGYIEKSLQQVEKLKKMEN KKIPDRIDYDAIKGIATEARQKLKNVRPLSVAQASRISGVNPADISILLVYLEQGRIA KIAE*" /label="trmF CDS" gene complement(3710488..3712374) /gene="trmF" /locus_tag="BSU_41010" /old_locus_tag="BSU41010" /label="trmF gene" CDS complement(3712395..3713774) /gene="mnmE" /locus_tag="BSU_41020" /old_locus_tag="BSU41020" /EC_number="3.6.-.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15522079, 15616586, 19052377, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA modification GTPase and tRNA-U34 5-formylation enzyme" /protein_id="NP_391982.1" /db_xref="EnsemblGenomes-Gn:BSU41020" /db_xref="EnsemblGenomes-Tr:CAB16139" /db_xref="GOA:P25811" /db_xref="InterPro:IPR004520" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR018948" /db_xref="InterPro:IPR025867" /db_xref="InterPro:IPR027368" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031168" /db_xref="SubtiList:BG10060" /db_xref="UniProtKB/Swiss-Prot:P25811" /translation="MDTIAAISTPMGEGAIAIVRLSGPEAIQIADKIYKGPKGKTLSS VESHTIHYGHIVDRPSDRVVEEVMVSVLKAPRTFTREDVIEINCHGGIVTVNQVLQLA LREGARLAEPGEFTKRAFLNGRIDLSQAEAVMDLIRAKTDRAMNVAMNQMEGRLSALV RRLRSEILETLAHVEVNIDYPEYDDVEEMTHQILVEKATAVKKEIETLLRTSEQGKIL REGLSTVIIGRPNVGKSSLLNSLVHEAKAIVTDIPGTTRDVIEEYVNVRGVPLRLVDT AGIRETEDIVERIGVERSRQVLKEADLILLVLNYSEELSEEDVKLFEAVEGMDVIVIL NKTDLEPKIDTERVRELANGRPVVTTSLLKEEGINDLEEAIQSLFYTGAIESGDLTYV SNTRHITILQQAKRAIEDALSGIEQDVPIDMVQIDLTRCWELLGEIIGDSVHESLIDQ LFSQFCLGK*" /label="mnmE CDS" gene complement(3712395..3713774) /gene="mnmE" /locus_tag="BSU_41020" /old_locus_tag="BSU41020" /label="mnmE gene" S_feature complement(3713775..3713905) /Source="Nicolas_S_feature" /locus_tag="new_4212890_4213020_c" /HighExp="dia15, Diami, LBGstat, H2O2, Paraq, dia5, G180, T0.30H, LBGexp, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1578" promotor_-10 complement(3713897..3713916) /Source="Nicolas_upshift_promotors" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3713905) /Source="Nicolas_upshifts" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3713932..3713936) /Source="Nicolas_upshift_promotors" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3713960..3713979) /Source="Nicolas_upshift_promotors" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="promotor_-10" upshifts complement(3713970) /Source="Nicolas_upshifts" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="upshifts" promotor_-35 complement(3713993..3714000) /Source="Nicolas_upshift_promotors" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="promotor_-35" promotor_-35 3714060..3714066 /Source="Nicolas_upshift_promotors" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3714071..3716356 /Source="Nicolas_S_feature" /locus_tag="new_4213186_4215471" /HighExp="T0.30H, C30, T1.0H, T1.30H, S2, T0.0H, T-1.10H, T-0.40H, T-1.40H, C90" /AntisenseName="oxaAA" /AntisenseCor="-0.20593684080740801" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.685" /TUlongSig="NA" /TUlongPSig="NA" /label="S1579" upshifts 3714071 /Source="Nicolas_upshifts" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3714081..3714100 /Source="Nicolas_upshift_promotors" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3714085..3714711) /gene="jag" /locus_tag="BSU_41030" /old_locus_tag="BSU41030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1487728, 12813085, 26883633, 27776484; Product type f: factor" /codon_start=1 /transl_table=11 /product="SpoIIIJ-associated RNA/ssDNA-binding protein" /protein_id="NP_391983.1" /db_xref="EnsemblGenomes-Gn:BSU41030" /db_xref="EnsemblGenomes-Tr:CAB16140" /db_xref="GOA:Q01620" /db_xref="InterPro:IPR001374" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR032782" /db_xref="InterPro:IPR034079" /db_xref="InterPro:IPR036867" /db_xref="SubtiList:BG10061" /db_xref="UniProtKB/Swiss-Prot:Q01620" /translation="MRNVTAAGRNVDEAVQSGLQELGLTKDKVEITVIEEGNKGFLGI FGKKPAIVKLVEKIDPIQQAKLYLQTIAEAIAGKSDVTVQESKKTVRYHITGEKAALL IGKRGQTLNALETLTQLALNRYPGQYKNVTVDAENYRLKRKETLSQLAIKLADQVLKT KKSIQLEPMPSSERKIIHDTLSGYANHQIKTYSMGEGENRHLVISHKR*" /label="jag CDS" gene complement(3714085..3714711) /gene="jag" /locus_tag="BSU_41030" /old_locus_tag="BSU41030" /label="jag gene" downshifts complement(3714102) /Source="Nicolas_upshifts" /id="D2126" /incds=0 /nref=229 /ntot=258 /MaxReadThrough="2.29192" /MaxDrop="6.32351" /score="24.2602773" /energy="-14.1" /TU="NA" /idTUdmin="U3239" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3714708..3715493) /gene="oxaAA" /locus_tag="BSU_41040" /old_locus_tag="BSU41040" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11889108, 12586834, 15654078, 15671040, 15849754, 15995216, 16850406, 24739968, 25133632, 25313395, 25359772, 25855636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11889108, 12586834, 15654078, 15671040, 15849754, 15995216, 16850406, 24739968, 25133632, 25313395, 25359772, 25855636; Product type f: factor" /codon_start=1 /transl_table=11 /product="Sec-independent factor for membrane protein insertion (YidC/SpoIIIJ family)" /protein_id="NP_391984.1" /db_xref="EnsemblGenomes-Gn:BSU41040" /db_xref="EnsemblGenomes-Tr:CAB16141" /db_xref="GOA:Q01625" /db_xref="InterPro:IPR001708" /db_xref="InterPro:IPR023060" /db_xref="InterPro:IPR028055" /db_xref="SubtiList:BG10062" /db_xref="UniProtKB/Swiss-Prot:Q01625" /translation="MLLKRRIGLLLSMVGVFMLLAGCSSVKEPITADSPHFWDKYVVY PLSELITYVAKLTGDNYGLSIILVTILIRLLILPLMIKQLRSSKAMQALQPEMQKLKE KYSSKDQKTQQKLQQETMALFQKHGVNPLAGCFPILIQMPILIGFYHAIMRTQAISEH SFLWFDLGEKDPYYILPIVAGVATFVQQKLMMAGNAQQNPQMAMMLWIMPIMIIVFAI NFPAALSLYWVVGNLFMIAQTFLIKGPDIKKNPEPQKAGGKKK*" /label="oxaAA CDS" gene complement(3714708..3715493) /gene="oxaAA" /locus_tag="BSU_41040" /old_locus_tag="BSU41040" /label="oxaAA gene" promotor_-10 complement(3715538..3715557) /Source="Nicolas_upshift_promotors" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3715550) /Source="Nicolas_upshifts" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3715552..3715637) /Source="Nicolas_S_feature" /locus_tag="new_4214667_4214752_c" /HighExp="G135, G180, H2O2, Oxctl, Paraq, G150, Cold, LPh, LBGexp, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1580" promotor_-35 complement(3715569..3715575) /Source="Nicolas_upshift_promotors" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3715638..3715988) /gene="rnpA" /locus_tag="BSU_41050" /old_locus_tag="BSU41050" /EC_number="3.1.26.5" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16061811, 16163391, 16980484, 17299131, 21347352, 24580115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein component of ribonuclease P (RNase P) (substrate specificity)" /protein_id="NP_391985.1" /db_xref="EnsemblGenomes-Gn:BSU41050" /db_xref="EnsemblGenomes-Tr:CAB16142" /db_xref="GOA:P25814" /db_xref="InterPro:IPR000100" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020539" /db_xref="InterPro:IPR020568" /db_xref="PDB:1A6F" /db_xref="PDB:4JG4" /db_xref="SubtiList:BG10063" /db_xref="UniProtKB/Swiss-Prot:P25814" /translation="MKKRNRLKKNEDFQKVFKHGTSVANRQFVLYTLDQPENDELRVG LSVSKKIGNAVMRNRIKRLIRQAFLEEKERLKEKDYIIIARKPASQLTYEETKKSLQH LFRKSSLYKKSSSK*" /label="rnpA CDS" gene complement(3715638..3715988) /gene="rnpA" /locus_tag="BSU_41050" /old_locus_tag="BSU41050" /label="rnpA gene" S_feature complement(3715989..3716139) /Source="Nicolas_S_feature" /locus_tag="new_4215104_4215254_c" /HighExp="G135, G180, Oxctl, H2O2, Paraq, Cold, G150, C30, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1581" CDS complement(3716140..3716274) /gene="rpmH" /locus_tag="BSU_41060" /old_locus_tag="BSU41060" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7539334, 9371771, 12682299, 23002217, 25182490" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7539334, 9371771, 12682299, 23002217, 25182490; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L34" /protein_id="NP_391986.1" /db_xref="EnsemblGenomes-Gn:BSU41060" /db_xref="EnsemblGenomes-Tr:CAB16143" /db_xref="GOA:P05647" /db_xref="InterPro:IPR000271" /db_xref="InterPro:IPR020939" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10064" /db_xref="UniProtKB/Swiss-Prot:P05647" /translation="MKRTFQPNNRKRSKVHGFRSRMSSKNGRLVLARRRRKGRKVLSA *" /label="rpmH CDS" gene complement(3716140..3716274) /gene="rpmH" /locus_tag="BSU_41060" /old_locus_tag="BSU41060" /label="rpmH gene" promotor_no_box 3716298..3716398 /Source="Nicolas_upshift_promotors" /id="U3241" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.047952047952048" /xcortree=1495 /SigmaFactorBS="agctgttaaagacagtcttacttattatatttgcgttaccta ttcattgtcaacttcactagtgcttttatttcttgcaaccataataggataccatacc t" /listShort="S1583" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(3716310..3716329) /Source="Nicolas_upshift_promotors" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3716320) /Source="Nicolas_upshifts" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3716322..3716390) /Source="Nicolas_S_feature" /locus_tag="new_4215437_4215505_c" /HighExp="Oxctl, G180, Paraq, H2O2, LBGstat, GM 120, MG-0.2, HPh, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1582" promotor_-35 complement(3716345..3716352) /Source="Nicolas_upshift_promotors" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3716358..>3716491 /Source="Nicolas_S_feature" /locus_tag="new_4215473_4215670" /HighExp="T0.30H, C30, T1.0H, T1.30H, T0.0H, T-0.40H, S2, T-1.10H, Pyr, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.048" /TUlongSig="NA" /TUlongPSig="NA" /label="S1583" upshifts 3716358 /Source="Nicolas_upshifts" /id="U3241" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.047952047952048" /xcortree=1495 /SigmaFactorBS="agctgttaaagacagtcttacttattatatttgcgttaccta ttcattgtcaacttcactagtgcttttatttcttgcaaccataataggataccatacc t" /listShort="S1583" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3716376..3716395) /Source="Nicolas_upshift_promotors" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3716390) /Source="Nicolas_upshifts" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3716411..3716415) /Source="Nicolas_upshift_promotors" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3716492..3716639 /locus_tag="new_1_148" /created_by="stephanmichalik" /label="S1" S_feature complement(3716515..3716788) /locus_tag="new_24_297_c" /created_by="stephanmichalik" /label="S2" S_feature 3716641..3716900 /locus_tag="new_150_409" /created_by="stephanmichalik" /label="S3" ORIGIN 1 atggaaaata tattagacct gtggaaccaa gcccttgctc aaatcgaaaa aaagttgagc 61 aaaccgagtt ttgagacttg gatgaagtca accaaagccc actcactgca aggcgataca 121 ttaacaatca cggctcccaa tgaatttgcc agagactggc tggagtccag atacttgcat 181 ctgattgcag atactatata tgaattaacc ggggaagaat tgagcattaa gtttgtcatt 241 cctcaaaatc aagatgttga ggactttatg ccgaaaccgc aagtcaaaaa agcggtcaaa 301 gaagatacat ctgattttcc tcaaaatatg ctcaatccaa aatatacttt tgatactttt 361 gtcatcggat ctggaaaccg atttgcacat gctgcttccc tcgcagtagc ggaagcgccc 421 gcgaaagctt acaacccttt atttatctat gggggcgtcg gcttagggaa aacacactta 481 atgcatgcga tcggccatta tgtaatagat cataatcctt ctgccaaagt ggtttatctg 541 tcttctgaga aatttacaaa cgaattcatc aactctatcc gagataataa agccgtcgac 601 ttccgcaatc gctatcgaaa tgttgatgtg cttttgatag atgatattca atttttagcg 661 gggaaagaac aaacccagga agaatttttc catacattta acacattaca cgaagaaagc 721 aaacaaatcg tcatttcaag tgaccggccg ccaaaggaaa ttccgacact tgaagacaga 781 ttgcgctcac gttttgaatg gggacttatt acagatatca caccgcctga tctagaaacg 841 agaattgcaa ttttaagaaa aaaggccaaa gcagagggcc tcgatattcc gaacgaggtt 901 atgctttaca tcgcgaatca aatcgacagc aatattcggg aactcgaagg agcattaatc 961 agagttgtcg cttattcatc tttaattaat aaagatatta atgctgatct ggccgctgag 1021 gcgttgaaag atattattcc ttcctcaaaa ccgaaagtca ttacgataaa agaaattcag 1081 agggtagtag gccagcaatt taatattaaa ctcgaggatt tcaaagcaaa aaaacggaca 1141 aagtcagtag cttttccgcg tcaaatcgcc atgtacttat caagggaaat gactgattcc 1201 tctcttccta aaatcggtga agagtttgga ggacgtgatc atacgaccgt tattcatgcg 1261 catgaaaaaa tttcaaaact gctggcagat gatgaacagc ttcagcagca tgtaaaagaa 1321 attaaagaac agcttaaata gcaggaccgg ggatcaatcg gggaaagtgt gaataacttt 1381 tcggaagtca tacacagtct gtccacatgt ggataggctg tgtttcctgt ctttttcaca 1441 acttatccac aaatccacag gccctactat tacttctact attttttata aatatatata 1501 ttaatacatt atccgttagg aggataaaaa tgaaattcac gattcaaaaa gatcgtcttg 1561 ttgaaagtgt ccaagatgta ttaaaagcag tttcatccag aaccacgatt cccattctga 1621 ctggtattaa aattgttgca tcagatgatg gagtatcctt tacagggagt gactcagata 1681 tttctattga atccttcatt ccaaaagaag aaggagataa agaaatcgtc actattgaac 1741 agcccggaag catcgtttta caggctcgct tttttagtga aattgtaaaa aaattgccga 1801 tggcaactgt agaaattgaa gtccaaaatc agtatttgac gattatccgt tctggtaaag 1861 ctgaatttaa tctaaacgga ctggatgctg atgaatatcc gcacttgccg cagattgaag 1921 agcatcatgc gattcagatc ccaactgatt tgttaaaaaa tctaatcaga caaacagtat 1981 ttgcagtgtc cacctcagaa acacgcccta tcttgacagg tgtaaactgg aaagtggagc 2041 aaagtgaatt attatgcact gcaacggata gccaccgtct tgcattaaga aaggcgaaac 2101 ttgatattcc agaagacaga tcttataacg tcgtgattcc gggaaaaagt ttaactgaac 2161 tcagcaagat tttagatgac aaccaggaac ttgtagatat cgtcatcaca gaaacccaag 2221 ttctgtttaa agcgaaaaac gtcttgttct tctcacggct tctggacggg aattatccag 2281 acacaaccag cctgattccg caagacagca aaacagaaat cattgtgaac acaaaagaat 2341 tccttcaggc cattgatcgt gcatctcttt tagctagaga gggacgcaac aacgttgtaa 2401 aactgtccgc aaaaccggct gaatccattg aaatttcttc caattcgcca gaaatcggta 2461 aagttgtgga agcaattgtt gcggatcaaa ttgaaggtga ggaattaaat atctctttta 2521 gtccaaaata tatgctggat gcactaaagg tgcttgaagg agcagaaata cgcgtaagct 2581 ttacaggcgc aatgagacct ttcttaattc gcacgccgaa tgatgaaacg attgtacagc 2641 ttatccttcc tgtcagaacc tattaatccg atacactgct gccgacccgt cggcagcttt 2701 tctattcggt atctgctccg acaagttttc cctttcccta attcgttttt ttttagtaca 2761 attagatatt agtgatattt gaaagaggtc gatataatgg caaatccgat ttcaattgat 2821 acagagatga ttacactcgg acaattctta aaattagccg atgtgattca gtctggcggt 2881 atggcgaagt ggtttttaag cgagcatgaa gtgcttgtga acgatgagcc ggacaaccgc 2941 cggggcagaa agctgtatgt tggagatgtg gtagagattg aaggatttgg ttcatttcaa 3001 gtcgtcaatt aaagcgggtg acactgattg tatatccaga acttagaact gacatcttac 3061 cgcaactacg accatgctga acttcaattt gaaaataaag taaatgtgat catcggagaa 3121 aacgcccagg ggaagacaaa cctcatggag gcgatctatg tcttgtccat ggcgaaatcg 3181 caccggacat caaatgacaa agaacttata cggtgggaca aagactatgc taaaatagag 3241 ggaagagtga tgaagcaaaa cggggcgatc ccgatgcagc tcgtcatctc caaaaagggt 3301 aaaaagggca aggtcaatca tattgaacag caaaagctca gccagtatgt cggggccctc 3361 aacaccatta tgttcgcgcc ggaagattta aatcttgtaa agggaagccc tcaagtgaga 3421 aggcggtttc ttgacatgga aatcggacag gtttctcccg tctaccttca tgatctttct 3481 ctttaccaga aaatcctttc ccagcggaat cattttttga aacagctgca aacaagaaaa 3541 caaactgacc ggacgatgct cgatgttctg accgatcagc ttgtagaagt tgcagcaaaa 3601 gtcgtcgtaa aacgcctgca gtttacagca cagctcgaga aatgggcgca gcccatccat 3661 gcaggcatct caagagggct tgaagaactg accctgaaat accatacagc tcttgatgta 3721 tcagatcccc tagatttgtc gaaaatagga gatagctatc aagaagcgtt ttctaaatta 3781 agagaaaaag aaattgagcg tggtgtgacg ctgtcagggc ctcatcgcga tgatgttctt 3841 ttctatgtga acggacgcga tgtgcagacg tatggttctc aaggacagca gcgaacgacg 3901 gcgttgtccc ttaagctggc ggagattgac ctgatccatg aagaaatcgg agaatatccc 3961 attttactat tggatgatgt actgagtgaa ctggatgatt atcgccagtc acacttgctt 4021 catacgatcc aaggccgtgt acaaacgttt gtcacaacga caagcgttga tggcattgat 4081 cacgaaacct tacgtcaagc aggaatgttc cgtgtgcaaa atggtgcgtt agtgaagtga 4141 agaaatgagg tgagcaattg tatattcatt taggtgatga ctttgtggtt tcaacacgag 4201 atattgtcgg catttttgac tttaaagcca acatgtcgcc tattgttgaa gaatttctga 4261 aaaaacagaa acacaaggtg gtgccttccg taaacggcac gcccaaatct atcgtagtca 4321 cggttcagaa tatatattac tctcccttat cttccagcac attaaaaaaa cgtgcgcaat 4381 ttatgtttga aatagattct tagaaatttt ttatcacgaa tatatcgttt agaaaagtgt 4441 aggtgaatga cgtggctatg gaacagcagc aaaacagtta tgatgaaaat cagatacagg 4501 tactagaagg attggaagct gttcgtaaaa gaccggggat gtatatcggt tcgacaaaca 4561 gcaaaggcct tcaccacttg gtatgggaaa ttgtcgacaa tagtattgac gaagccctcg 4621 ccggttattg tacggatatc aatatccaaa tcgaaaaaga caacagtatc acggttgtag 4681 ataatggccg cggtattcca gtcggtattc atgaaaaaat gggccgtcct gcggtagaag 4741 tcattatgac ggtgcttcat gccggaggaa aatttgacgg aagcggctat aaagtatccg 4801 gaggattaca cggtgtaggt gcgtcggtcg taaacgcact atcaacagag cttgatgtga 4861 cggttcaccg tgacggtaaa attcaccgcc aaacctataa acgcggagtt ccggttacag 4921 accttgaaat cattggcgaa acggatcata caggaacgac gacacatttt gtcccggacc 4981 ctgaaatttt ctcagaaaca accgagtatg attacgatct gcttgccaac cgcgtgcgtg 5041 aattagcctt tttaacaaag ggcgtaaaca tcacgattga agataaacgt gaaggacaag 5101 agcgcaaaaa tgaataccat tacgaaggcg gaattaaaag ttatgtagag tatttaaacc 5161 gctctaaaga ggttgtccat gaagagccga tttacattga aggcgaaaag gacggcatta 5221 cggttgaagt ggctttgcaa tacaatgaca gctacacaag caacatttac tcgtttacaa 5281 acaacattaa cacgtacgaa ggcggtaccc atgaagctgg cttcaaaacg ggcctgactc 5341 gtgttatcaa cgattacgcc agaaaaaaag ggcttattaa agaaaatgat ccaaacctaa 5401 gcggagatga cgtaagggaa gggctgacag cgattatttc aatcaaacac cctgatccgc 5461 agtttgaggg ccaaacaaaa acaaagctgg gcaactcaga agcacggacg atcaccgata 5521 cgttattttc tacggcgatg gaaacattta tgctggaaaa tccagatgca gccaaaaaaa 5581 ttgtcgataa aggtttaatg gcggcaagag caagaatggc tgcgaaaaaa gcgcgtgaac 5641 taacacgccg taagagtgct ttggaaattt caaacctgcc cggtaagtta gcggactgct 5701 cttcaaaaga tccgagcatc tccgagttat atatcgtaga gggtgactct gccggaggat 5761 ctgctaaaca aggacgcgac agacatttcc aagccatttt gccgcttaga ggtaaaatcc 5821 taaacgttga aaaggccaga ctggataaaa tcctttctaa caacgaagtt cgctctatga 5881 tcacagcgct cggcacaggt atcggagaag acttcaacct tgagaaagcc cgttaccaca 5941 aagttgtcat tatgacagat gccgatgttg acggcgcgca catcagaaca ctgctgttaa 6001 cgttctttta cagatatatg cgccaaatta tcgaaaatgg ctacgtgtac attgcgcagc 6061 cgccgctcta caaggttcaa caggggaaac gcgttgaata tgcatacaat gacaaggagc 6121 ttgaagagct gttaaaaact cttcctcaaa cgcctaagcc tggactgcag cgttacaaag 6181 gtcttggtga aatgaatgcc acccagctat gggagacaac catggatcct agctccagaa 6241 cacttcttca ggtaactctt gaagatgcaa tggatgcgga tgagactttt gaaatgctta 6301 tgggcgacaa ggtagaaccg cgccgaaact tcatagaagc gaatgcgaga tacgttaaaa 6361 atcttgacat ctaatcataa aaagccttat ttccaataag aaataaggct tttttctgaa 6421 caagatcaga tgcagcgatg cctgcaatac ctatatattc tagcaattta atgtgtataa 6481 tcataagttt attgatataa tggagaatag tgaaatcgta ttgaaggtca taatggacaa 6541 tctactccca catatttcat gtgatacttc agggaggttt tttaatgagt gaacaaaaca 6601 caccacaagt tcgtgaaata aatatcagtc aggaaatgcg tacgtccttc ttggattatg 6661 caatgagcgt tatcgtgtcc cgtgctcttc cggatgttcg tgacggttta aaaccggttc 6721 atagacggat tttgtatgca atgaatgatt taggcatgac aagtgacaag ccttataaaa 6781 aatccgcgcg tatcgttgga gaagttatcg ggaaatacca cccgcacggt gattcagcgg 6841 tatatgaatc catggtcaga atggctcagg atttcaacta ccgttatatg ctcgttgacg 6901 gtcacggaaa cttcggttct gttgacggag actcagcggc ggccatgcgt tatacagaag 6961 cacgaatgtc taaaatctca atggagattc ttcgcgacat cacaaaagac acaatcgatt 7021 accaggataa ctatgacggg tcagaaagag aacctgtcgt tatgccttca aggttcccga 7081 atctgctcgt gaacggtgct gccggcattg cggtaggtat ggcaacaaac attcctccgc 7141 accagctggg agaaatcatt gacggtgtac ttgctgttag tgagaatccg gacattacaa 7201 ttccagagct tatggaagtc attccagggc ctgatttccc gaccgcgggt caaatcttgg 7261 gacgcagcgg tatccggaaa gcatacgaat caggccgagg ctctatcacg atccgggcaa 7321 aagctgagat cgaacaaaca tcttcgggta aagaaagaat tatcgttaca gagttacctt 7381 accaagtaaa taaggcgaaa ttaattgaga aaattgctga tctcgtaagg gacaaaaaga 7441 tagagggtat cacagatctg cgtgatgagt cagatcgtac aggtatgaga attgtcattg 7501 aaatcagacg cgatgccaat gcgaatgtta tcttaaacaa tctgtacaaa caaactgctc 7561 tacaaacatc ttttggcatc aacctgcttg cgcttgttga tggccagccg aaagttttaa 7621 ctcttaagca atgcctggag cattaccttg accatcaaaa agttgtcatt agacgccgta 7681 ctgcttatga attgcgtaaa gcagaagcga gagctcatat cttggaagga ttgagagttg 7741 cactggatca tctcgatgca gttatctccc ttatccgtaa ttctcaaacg gctgaaattg 7801 cgagaacagg tttaattgaa caattctcac tgacagagaa gcaagcacaa gcgatccttg 7861 acatgaggct ccagcgttta acgggactgg aacgtgaaaa gatcgaagaa gaataccagt 7921 ctcttgttaa attaattgca gagctaaaag acatcttggc aaatgaatat aaagtgcttg 7981 agatcattcg tgaagaactc acggaaatca aagagcgttt taacgatgaa agacgtactg 8041 agatcgtcac ttctggactg gagacaattg aagatgaaga tctcatcgag agagaaaata 8101 tcgtagttac tctgacgcac aacggatacg tcaaacgtct tcctgcatca acttaccgca 8161 gtcaaaaacg gggcggaaaa ggtgtacaag gtatgggaac aaacgaagat gatttcgttg 8221 aacatttgat ctctacgtca actcatgaca cgattctctt cttctcgaac aaggggaaag 8281 tgtatcgtgc aaaagggtat gaaatccctg aatacggcag aacggcaaaa ggaatcccga 8341 ttattaacct gctggaggta gaaaagggtg agtggatcaa cgcgattatt ccagtcacgg 8401 aattcaatgc ggagctttac ctcttcttca ctacaaagca tggggtttca aaacgaacat 8461 cgctatctca attcgctaat atccgcaaca atggtctaat tgctctgagt cttcgtgaag 8521 atgatgaact gatgggtgta cgtctgactg acggcacaaa acaaatcatc attggaacga 8581 aaaacggttt actgattcgt ttccctgaaa cagatgtccg agagatggga agaactgcgg 8641 cgggcgtaaa aggcatcacc ctgacggatg acgacgttgt tgtcggcatg gagattttag 8701 aggaagaatc acacgtcctt atcgtaactg aaaaagggta cggaaaacga actcctgctg 8761 aagagtacag aacccaaagc cggggcggaa aaggactcaa aacagcgaaa atcaccgaga 8821 acaacggcca actagtagca gtgaaagcta ctaaaggtga agaggatcta atgattatta 8881 cagctagcgg cgtactcatc agaatggaca tcaatgatat ctccatcacc ggacgtgtca 8941 ctcaaggtgt gcgtctcatc agaatggcag aagaagagca tgttgctaca gtagctttag 9001 ttgagaaaaa cgaagaagat gagaatgaag aagaacaaga agaagtgtga aaaaaagcgc 9061 agctgaaata gctgcgcttt tttgtgtcat aaccctttac agtcataaaa attatggtat 9121 aatcatttct gttgtctttt taaagacaca agcatgacca ttatgactag taaaaacttt 9181 ttcaaaaaag tattgaccta gttaactaaa aatgttacta ttaagtagtc gctttgagag 9241 aagcacacaa agttctttga aaactaaaca agacaaaacg tacctgttaa ttcattttta 9301 taaatcgcac agcgatgtgc gtagtcagtc aaactagggc ctgcacgacg caggtcacac 9361 aggtgtcgcc gcaggatgcg gtgaacttaa cctgtgatcc atttatcgga gagtttgatc 9421 ctggctcagg acgaacgctg gcggcgtgcc taatacatgc aagtcgagcg gacagatggg 9481 agcttgctcc ctgatgttag cggcggacgg gtgagtaaca cgtgggtaac ctgcctgtaa 9541 gactgggata actccgggaa accggggcta ataccggatg gttgtttgaa ccgcatggtt 9601 caaacataaa aggtggcttc ggctaccact tacagatgga cccgcggcgc attagctagt 9661 tggtgaggta acggctcacc aaggcgacga tgcgtagccg acctgagagg gtgatcggcc 9721 acactgggac tgagacacgg cccagactcc tacgggaggc agcagtaggg aatcttccgc 9781 aatggacgaa agtctgacgg agcaacgccg cgtgagtgat gaaggttttc ggatcgtaaa 9841 gctctgttgt tagggaagaa caagtgccgt tcgaataggg cggtaccttg acggtaccta 9901 accagaaagc cacggctaac tacgtgccag cagccgcggt aatacgtagg tggcaagcgt 9961 tgtccggaat tattgggcgt aaagggctcg caggcggttt cttaagtctg atgtgaaagc 10021 ccccggctca accggggagg gtcattggaa actggggaac ttgagtgcag aagaggagag 10081 tggaattcca cgtgtagcgg tgaaatgcgt agagatgtgg aggaacacca gtggcgaagg 10141 cgactctctg gtctgtaact gacgctgagg agcgaaagcg tggggagcga acaggattag 10201 ataccctggt agtccacgcc gtaaacgatg agtgctaagt gttagggggt ttccgcccct 10261 tagtgctgca gctaacgcat taagcactcc gcctggggag tacggtcgca agactgaaac 10321 tcaaaggaat tgacgggggc ccgcacaagc ggtggagcat gtggtttaat tcgaagcaac 10381 gcgaagaacc ttaccaggtc ttgacatcct ctgacaatcc tagagatagg acgtcccctt 10441 cgggggcaga gtgacaggtg gtgcatggtt gtcgtcagct cgtgtcgtga gatgttgggt 10501 taagtcccgc aacgagcgca acccttgatc ttagttgcca gcattcagtt gggcactcta 10561 aggtgactgc cggtgacaaa ccggaggaag gtggggatga cgtcaaatca tcatgcccct 10621 tatgacctgg gctacacacg tgctacaatg gacagaacaa agggcagcga aaccgcgagg 10681 ttaagccaat cccacaaatc tgttctcagt tcggatcgca gtctgcaact cgactgcgtg 10741 aagctggaat cgctagtaat cgcggatcag catgccgcgg tgaatacgtt cccgggcctt 10801 gtacacaccg cccgtcacac cacgagagtt tgtaacaccc gaagtcggtg aggtaacctt 10861 ttaggagcca gccgccgaag gtgggacaga tgattggggt gaagtcgtaa caaggtagcc 10921 gtatcggaag gtgcggctgg atcacctcct ttctaaggat attttacgga atataagacc 10981 ttgggtctta taaacagaac gttccctgtc ttgtttagtt ttgaaggaac tttgttcctt 11041 gaataagtta agatgggcct gtagctcagc tggttagagc gcacgcctga taagcgtgag 11101 gtcggtggtt cgagtccact caggcccacc atcttatata acggggcctt agctcagctg 11161 ggagagcgcc tgctttgcac gcaggaggtc agcggttcga tcccgctagg ctccaccaac 11221 gtgttctttg aaaactagat aacagtagac atcacattca attagtaaca caagatatca 11281 catagtgatt ctttttaacg gttaagttag aaagggcgca cggtggatgc cttggcacta 11341 ggagccgatg aaggacggga cgaacaccga tatgcttcgg ggagctgtaa gcaagctttg 11401 atccggagat ttccgaatgg ggaaacccac cactcgtaat ggagtggtat ccatatctga 11461 attcatagga tatgagaagg cagacccggg gaactgaaac atctaagtac ccggaggaag 11521 agaaagcaaa tgcgattccc tgagtagcgg cgagcgaaac gggatcagcc caaaccaaga 11581 ggcttgcctc ttggggttgt aggacactct gtacggagtt acaaaggaac gaggtagatg 11641 aagaggtctg gaaaggcccg ccataggagg taacagccct gtagtcaaaa cttcgttctc 11701 tcctgagtgg atcctgagta cggcggaaca cgtgaaattc cgtcggaatc cgggaggacc 11761 atctcccaag gctaaatact ccctagtgac cgatagtgaa ccagtaccgt gagggaaagg 11821 tgaaaagcac cccggaaggg gagtgaaaga gatcctgaaa ccgtgtgcct acaagtagtc 11881 agagcccgtt aacgggtgat ggcgtgcctt ttgtagaatg aaccggcgag ttacgatctc 11941 gtgcaaggtt aagcagaaga tgcggagccg cagcgaaagc gagtctgaat agggcgcatg 12001 agtacgtggt cgtagacccg aaaccaggtg atctacccat gtccagggtg aagttcaggt 12061 aacactgaat ggaggcccga acccacgcac gttgaaaagt gcggggatga ggtgtgggta 12121 ggggtgaaat gccaatcgaa cctggagata gctggttctc tccgaaatag ctttagggct 12181 agcctcaagg taagagtctt ggaggtagag cactgattgg actaggggcc cctaccgggt 12241 taccgaattc agtcaaactc cgaatgccaa tgacttatcc ttgggagtca gactgcgagt 12301 gataagatcc gtagtcgaaa gggaaacagc ccagaccgcc agctaaggtc ccaaagtata 12361 cgttaagtgg aaaaggatgt ggagttgctt agacaaccag gatgttggct tagaagcagc 12421 caccatttaa agagtgcgta atagctcact ggtcgagtga ctctgcgccg aaaatgtacc 12481 ggggctaaac gtatcaccga agctgcggac tgttcttcga acagtggtag gagagcgttc 12541 taagggctgt gaagccagac cggaaggact ggtggagcgc ttagaagtga gaatgccggt 12601 atgagtagcg aaagaggggt gagaatcccc tccaccgaat gcctaaggtt tcctgaggaa 12661 ggctcgtccg ctcagggtta gtcgggacct aagccgaggc cgaaaggcgt aggcgatgga 12721 caacaggttg atattcctgt accacctcct caccatttga gcaatggggg gacgcaggag 12781 gatagggtaa gcgcggtatt ggatatccgc gtccaagcag ttaggctggg aaataggcaa 12841 atccgtttcc cataaggctg agctgtgatg gcgagcgaaa tatagtagcg aagttcctga 12901 ttccacactg ccaagaaaag cctctagcga ggtgagaggt gcccgtaccg caaaccgaca 12961 caggtaggcg aggagagaat cctaaggtga tcgagagaac tctcgttaag gaactcggca 13021 aaatgacccc gtaacttcgg gagaaggggt gctctgttag ggtgcaagcc cgagagagcc 13081 gcagtgaata ggcccaggcg actgtttagc aaaaacacag gtctctgcga agccgtaagg 13141 cgaagtatag gggctgacgc ctgcccggtg ctggaaggtt aagaggagcg cttagcgtaa 13201 gcgaaggtgc gaattgaagc cccagtaaac ggcggccgta actataacgg tcctaaggta 13261 gcgaaattcc ttgtcgggta agttccgacc cgcacgaaag gcgcaacgat ctgggcactg 13321 tctcaacgag agactcggtg aaattatagt acctgtgaag atgcaggtta cccgcgacag 13381 gacggaaaga ccccgtggag ctttactgca gcctgatatt gaatgttggt acagcttgta 13441 caggataggt aggagccttg gaaaccggag cgccagcttc ggtggaggca tcggtgggat 13501 actaccctgg ctgtattgac cttctaaccc gccgccctta tcgggcgggg agacagtgtc 13561 aggtgggcag tttgactggg gcggtcgcct cctaaaaggt aacggaggcg cccaaaggtt 13621 ccctcagaat ggttggaaat cattcgcaga gtgtaaaggc acaagggagc ttgactgcga 13681 gacctacaag tcgagcaggg acgaaagtcg ggcttagtga tccggtggtt ccgcatggaa 13741 gggccatcgc tcaacggata aaagctaccc cggggataac aggcttatct cccccaagag 13801 tccacatcga cggggaggtt tggcacctcg atgtcggctc atcgcatcct ggggctgtag 13861 tcggtcccaa gggttgggct gttcgcccat taaagcggta cgcgagctgg gttcagaacg 13921 tcgtgagaca gttcggtccc tatccgtcgc gggcgcagga aatttgagag gagctgtcct 13981 tagtacgaga ggaccgggat ggacgcaccg ctggtgtacc agttgttctg ccaagggcat 14041 cgctgggtag ctatgtgcgg acgggataag tgctgaaagc atctaagcat gaagcccccc 14101 tcaagatgag atttcccatt ccgcaaggaa gtaagatccc tgaaagatga tcaggttgat 14161 aggtctgagg tggaagtgtg gcgacacatg gagctgacag atactaatcg atcgaggact 14221 taaccatatt tttgaatgat gtcacacctg ttatctagtt ttgagagaac actctcaatt 14281 tgtttggtgg cgatagcgaa gaggtcacac ccgttcccat accgaacacg gaagttaagc 14341 tcttcagcgc cgatggtagt cgggggtttc cccctgtgag agtaggacgc cgccaagcaa 14401 gcttaaaccc agctcaatga gctgggtttt ttgtttgtta aaaatgaaga agaaactgtg 14461 aagcgtattt agggaatttc ttttctgata ctaataaaaa ctgctgaatt aacacgtagt 14521 catcacttat atgctgtgtt aataactcat accaccattc tgtttcatac cttgcaatca 14581 tcccaacgtt gtacaaaatc aaataatgaa ttgtcatttc gggaagcctc agaaattgct 14641 ccctttgaga agggatataa tattggttct tttccatgtc aaacaataag ctggtcgatg 14701 tccatggctc cttgtcttgt ggtgaaattt cgaacagcag cccgtgttca tttttttttg 14761 taaaagacca ttgataatga tgggacatgt attcagcaaa ccttgaatca gacattttgt 14821 aattgattac tacttcctcc ggtacaaaaa tttcgttctt atccttctca acttttgtca 14881 taaatcgttc tttctgctga aagtagaaaa tatcgctaag ttctggaatg gccattaata 14941 attttttcat ggtataccgt tcatctacta tatccgattg tccgaataaa tgtttcataa 15001 aatgtacgca taggccattc cgttgtattt tcacttcatc gtcgctaaaa caataatttt 15061 gtttctttcg ttttcttgtt gttacgccat gtgccagtac tgatgtatgg cttggataat 15121 gaggatcacg tgtaattaag catgctttga taagctgtgc cattccataa aataaaagaa 15181 tcggtttgat ttctaaggga gaatatgcgg cttgtttata aaacgattcg gcatgcttta 15241 agaaataaat aaaccgttca ctgtttttaa aagagttttt tttcgcatcg ttaataccgt 15301 ttaagatata aaccttttct agaaatttct gggttgattc aacggagtaa aatagcgcta 15361 agtctttcca ctcatgatat gtcatgtata tttcttaatc ctttccgtta tctaaatatt 15421 tcaactcttt cccgcttcct tgacatgctc ttggctagtt gataatctac atataatatt 15481 ttgccgaaaa gagggggatt tactaatgtg ggaaagtaaa ttttcaaaag aaggcttaac 15541 gttcgacgat gtgctgcttg taccagcaaa gtctgaggta cttccgcgtg atgtggattt 15601 atctgtagaa cttacaaaaa cgttaaagct aaatattcct gtcatcagcg caggtatgga 15661 cactgtaaca gaatcagcaa tggcaattgc aatggcaaga cagggcggct tgggcatcat 15721 tcacaaaaat atgtccattg aacagcaggc tgaacaagtt gataaagtaa agcgttctga 15781 gcgcggcgtt atcacaaatc ccttcttttt aactcctgat caccaagtat ttgatgcgga 15841 gcatttgatg gggaaataca gaatttccgg tgttccgatt gtaaataacg aagaagacca 15901 gaagcttgtt ggaattatta caaaccgtga ccttcgtttt atttctgact actcaatgaa 15961 aatcagcgac gtcatgacga aagaagagct agttactgca tctgtaggaa ctactctgga 16021 tgaagctgaa aagattttgc agaaacataa aattgaaaag cttcctctcg tagatgacca 16081 gaataaatta aaaggtctta tcacaattaa agacattgaa aaagtcattg agttcccgaa 16141 ctcatctaaa gacattcacg gccgcctgat cgttggcgcg gcagttggtg taactggcga 16201 tacaatgact cgcgtcaaaa agcttgttga agccaatgtt gatgtgattg ttatcgatac 16261 agctcacgga cactctcaag gcgttttaaa cacagtcaca aaaatccgtg aaacgtatcc 16321 cgaattaaac attattgctg gaaacgtggc aacagctgaa gcgacaagag cgcttatcga 16381 agctggagca gacgttgtca aagttggaat agggcctggt tcaatttgta ctacacgtgt 16441 tgtagccggc gtgggtgttc cgcaaattac agcaatttat gattgtgcga ctgaagcaag 16501 aaaacacggc aaaacaatca tcgccgacgg tgggattaaa ttctctggcg atatcactaa 16561 agcattggca gccggcggac atgctgttat gctcggaagc ttgcttgcag gcacatcaga 16621 aagccctggt gaaactgaaa tctaccaagg cagaagattt aaggtatacc gcggcatggg 16681 atcagttgct gcaatggaaa aaggaagtaa agaccgttac ttccaagaag aaaacaaaaa 16741 atttgttcct gaaggaattg aaggacgcac accttacaaa gggccagttg aagaaaccgt 16801 ttatcagcta gtcggaggcc ttcgttctgg tatggggtat tgcgggtcca aagatctgcg 16861 tgcgctaaga gaagaagctc agttcattcg catgactggc gcaggacttc gcgaaagcca 16921 tccgcatgac gtacagatta caaaagaatc acctaactat acaatttcat aataaattgt 16981 tacaaattaa aaacatttga cagggtctct gactctgtct atttttttta tactgattat 17041 gataaaattt atactgttgt gcattgaaaa tgtccttaac ggcttaatta tagatgaaga 17101 aaatgaaata cggaggtcgt acgattgaac atcaagaaat gtaaacagct actgatgtca 17161 ttggttgtgt taactctagc tgtcacgtgt ctggctccaa tgtcaaaagc gaaagcagcc 17221 agcgatccaa ttgatatcaa tgcatctgct gctattatga tcgaagcttc ttcaggtaaa 17281 attctttaca gtaaaaatgc agataagaga ctgccaattg cgagtatgac aaaaatgatg 17341 acagagtatc tgttattgga agcaattgat caaggtaaag tgaaatggga ccaaacctat 17401 acgcctgatg actatgtgta tgaaatttcc caagataaca gcttatcaaa cgttcctctt 17461 cggaaagacg ggaaatacac agtaaaagaa ttatatcaag ctacagcaat ttattctgca 17521 aatgctgctg ctattgcgat tgcagaaatc gttgccggtt ctgaaactaa gtttgttgaa 17581 aaaatgaatg caaaagcaaa agaactaggc ttaacagatt acaaatttgt taacgcaaca 17641 ggtcttgaaa acaaagatct tcacgggcat cagcctgagg ggacaagcgt aaatgaagaa 17701 agtgaagttt ctgcaaagga tatggcggtt cttgcggatc acttgattac tgactaccct 17761 gagatactgg agacttccag tatcgccaaa acgaaattca gagaaggcac cgatgatgaa 17821 atggacatgc cgaactggaa ttttatgctg aaggggcttg tcagcgagta taaaaaagcg 17881 actgtagacg gactgaaaac aggttctact gactctgcgg gttcatgctt tacaggaaca 17941 gctgaacgca acggtatgcg tgtcatcact gttgttttaa acgcaaaggg caaccttcat 18001 acaggccgtt tcgatgaaac gaaaaaaatg tttgattatg ctttcgacaa tttctccatg 18061 aaagaaattt atgctgaagg cgatcaagta aaaggccata aaacaatttc agttgataag 18121 ggtaaagaga aagaagtagg cattgtgaca aacaaggcgt tctctcttcc tgtcaaaaat 18181 ggtgaagaaa agaattacaa agcgaaggtc acactgaata aagacaactt aactgctcct 18241 gtgaaaaaag gaaccaaggt tgggaagctg actgcggaat acacaggtga tgaaaaggat 18301 tacggattcc ttaacagcga tctggctggc gtagaccttg ttacaaaaga aaatgtagaa 18361 aaagcaaact ggtttgtttt gacaatgcgc agtatcggcg gattttttgc cggaatttgg 18421 ggaagcattg ttgatacggt aaccggctgg ttttaatcaa ttgaaagagc tctgatggat 18481 gttagggctc tttcgcgtaa tatactgaaa aaacccaatt tttaataaaa aatgattttc 18541 aaagcgctaa aaaccgaata aaatagtata tatgcatatg aattattgga tttctaggat 18601 acaataagga ttagaaatca tataactata ccttgattag ggggaccaag aaatggctca 18661 aacaggtact gaacgtgtaa aacgcggaat ggcagaaatg caaaaaggcg gcgtcatcat 18721 ggacgtcatc aatgcggaac aagcgaaaat cgctgaagaa gctggagctg tcgctgtaat 18781 ggcgctagaa cgtgtgccag cagatattcg cgcggctgga ggagttgccc gtatggctga 18841 ccctacaatc gtggaagaag taatgaatgc agtatctatc ccggtaatgg caaaagcgcg 18901 tatcggacat attgttgaag cgcgtgtgct tgaagctatg ggtgttgact atattgatga 18961 aagtgaagtt ctgacgccgg ctgacgaaga atttcattta aataaaaatg aatacacagt 19021 tccttttgtc tgtggctgcc gtgatcttgg tgaagcaaca cgccgtattg cggaaggtgc 19081 ttctatgctt cgcacaaaag gtgagcctgg aacaggtaat attgttgagg ctgttcgcca 19141 tatgcgtaaa gttaacgctc aagtgcgcaa agtagttgcg atgagtgagg atgagctaat 19201 gacagaagcg aaaaacctag gtgctcctta cgagcttctt cttcaaatta aaaaagacgg 19261 caagcttcct gtcgttaact ttgccgctgg cggcgtagca actccagctg atgctgctct 19321 catgatgcag cttggtgctg acggagtatt tgttggttct ggtattttta aatcagacaa 19381 ccctgctaaa tttgcgaaag caattgtgga agcaacaact cactttactg attacaaatt 19441 aatcgctgag ttgtcaaaag agcttggtac tgcaatgaaa gggattgaaa tctcaaactt 19501 acttccagaa cagcgtatgc aagaacgcgg ctggtaagaa cataggagcg ctgctgacat 19561 gttaacaata ggtgtactag gacttcaagg agcagttaga gagcacatcc atgcgattga 19621 agcatgcggc gcggctggtc ttgtcgtaaa acgtccggag cagctgaacg aagttgacgg 19681 gttgattttg ccgggcggtg agagcacgac gatgcgccgt ttgatcgata cgtatcaatt 19741 catggagccg cttcgtgaat tcgctgctca gggcaaaccg atgtttggaa catgtgccgg 19801 attaattata ttagcaaaag aaattgccgg ttcagataat cctcatttag gtcttctgaa 19861 tgtggttgta gaacgtaatt catttggccg gcaggttgac agctttgaag ctgatttaac 19921 aattaaaggc ttggacgagc cttttactgg ggtattcatc cgtgctccgc atattttaga 19981 agctggtgaa aatgttgaag ttctatcgga gcataatggt cgtattgtag ccgcgaaaca 20041 ggggcaattc cttggctgct cattccatcc ggagctgaca gaagatcacc gagtgacgca 20101 gctgtttgtt gaaatggttg aggaatataa gcaaaaggca cttgtataaa acagttgaaa 20161 gctgtggaaa cttatagtac attataagca caaataaaga tcgaaaagcg ttgataggaa 20221 ctagtaggga gcctctcttt ctaagagagc cgatggttgg tgcgaatcgg tgaaagatgc 20281 tgtctgaatc catccttgag cgaaatgctg aagcgagtag gcatttacgg gataaccgtt 20341 atgtttgaaa gtggaaaacg agtctttgat ttgttttcaa tcagggtggc aacgcgagag 20401 ctctcgtccc tttatgggga tgagggctct ttttattttc gataaatcaa taaaaaaagg 20461 agtgtttcgc atgcttgata cgaaaatgct gagagcaaat tttcaagaaa ttaaagcaaa 20521 gcttgtacac aaaggcgaag acttaactga ttttgataag tttgaggcgc tggatgatag 20581 acgaagagag cttatcggca aggttgaaga gttaaaagga aaacgaaatg aagtttctca 20641 gcaggttgct gtgctgaagc gtgagaaaaa agacgcggat cacattatta aagaaatgcg 20701 tgaagtcggc gaggaaatta aaaagctcga tgaagaatta cggacagtgg aagctgagct 20761 tgatacaatc ctgctctcaa tcccgaatat tccgcatgag tctgtacctg tcggtgaaac 20821 agaagacgac aacgtagaag tgcgtaaatg gggtgaaaag ccttcatttg cttatgagcc 20881 gaagccgcac tgggatattg cggatgagct gggtattctg gattttgaac gtgctgccaa 20941 agtaacagga agccgtttcg tgttctataa aggcttaggt gctcgtctgg agcgtgcgct 21001 ttataacttt atgcttgatc tgcatgtgga tgagtataac tacactgaag tgatcccgcc 21061 atatatggta aaccgcgcaa gcatgacggg aacggggcag cttcctaaat ttgaagagga 21121 tgcatttaaa atcagagaag aagattattt cttaattcca acggcggaag tgccgattac 21181 aaacatgcat cgcgatgaaa tcctttcagg tgacagcctg ccgatcaact atgcggcatt 21241 cagtgcttgc ttccgttctg aagctggttc agcaggacgt gacacacgcg gattaattcg 21301 tcagcaccaa tttaataaag ttgagcttgt aaagtttgtg aagcctgaag attcttatga 21361 agaattagag aaacttacaa accaagcaga acgggttctt cagctgcttg agcttccata 21421 ccgtgtcatg agcatgtgta cgggtgactt aggctttacg gctgcgaaaa aatacgatat 21481 cgaagtttgg attccaagcc aagacacata tcgagaaatc tcttcttgca gcaacttcga 21541 agcgttccag gcgagacgtg cgaatattcg tttcagacgt gaagcgaaag gcaagcctga 21601 gcatgtacac acactgaacg gctcaggact ggcggttgga agaacagttg ctgctatctt 21661 agaaaattat cagcaggaag acggaagcgt tgtgattccg aaagtgcttc gtccttatat 21721 ggggaataga gaagtaatga aaccgtaaat tatggaaagg cgtgcctgac aaggtgcgcc 21781 tttttgctta tgtaaacacg gcattttcat aaaaacaaaa aaagttttta aaaatgcttg 21841 accacacgag aacatacgtg atatagttag tcttgtcgat acggaggaat acccaagtcc 21901 ggctgaaggg atcggtcttg aaaaccgaca ggggtgtcaa agcccgcggg ggttcgaatc 21961 cctcttcctc cgccatattg attttaattc taatgaaaca caagcatata ttggagattg 22021 ttttgtccgt tgcattcggt gcggcggatt ttttatttta aagaaaaagt gaatctcgac 22081 tgagattcac tttttttgat tatcatgaat aactgaagca atttgatcta caatattttc 22141 aatcgagttt tcgtcgttca gaagatcata atcttcaatg cgaagtttta aaacagggca 22201 ggcattaaaa ccgcttatcc agttctcgta gcgtgtatgc atttcttccc aataagaccg 22261 gcttgtctga agctccatct cacggccgcg ttgttcaatc cggtttaaaa tgttctccag 22321 atctccttct aaatagatca acacatctgg atgtgggaaa tacggtgtca ttaccattgc 22381 ttcgaaaagg cttgtgtaag tcttataatc aacctttgac attgtccctt tatcagcatg 22441 catttttgcg aaaattcctg tatcttcata aatcgaacga tcctgtacaa aacctccgcc 22501 ggcttcaaaa attgttttct gttctttgaa gcgttcagct aagaagtaaa tttgaaggtg 22561 aaagctccaa cgttcaaaat catgatagaa cttttccaaa tatggattat gatcgacttc 22621 ctccaacgat gttttaaatc caagccgttt agctaaagtt tttgttaaag tcgattttcc 22681 gacacctact gttcctgcta ctgtaataat tgaattctta gggatatgat gttccttcat 22741 acgataagct cctttacatg ggcggcaatg cgttcaaagt cgctcttatt caaaacgaaa 22801 tcctttgaat caccatctac ggttaacact gtaagttcag ggtctgcttc ctgcagctgc 22861 ttgatggcga cttcataatc tgaaatcagc tgctccaaat agctagtttc aatttttttc 22921 tcaaaggggc gcccgcgttt ttcaatgcgg tgtagcaatg taggcagact ggcctttatg 22981 taaatgatga aattcggctt tggcagatca tccgttagca ggtgatatat ctttttgtat 23041 ttttccagct gatgtggaga caaggttcgt tccgcaaaaa tcacattttt ataaatatga 23101 taatcagcta ttacaggctg tccctttttt aaaaagtgat cactggtgtc ttcaagctgt 23161 ttgtatctgt gacaaagaaa aaacatctcg agctggaagc tccattcctt tatattgtca 23221 taaaacttat caaggtacgg gttatcctct acaatctcat tgatcatagg gaatccgaat 23281 ttttgtgaga gcatcgttgc gagagttgtt tttcctgccc cgataggacc ttctattgca 23341 ataaaagggg ctgtattcat cggaatcctc cttatatctg aaaaacgtgc gtcagttacc 23401 gaccttcata ttgtatcaca acccttgggt gcccccatga aaaaaagacg tttccaaatt 23461 atcgaaacgt ctttttgaca acattaaatt gatcagacag cagcagccag ttttgtggaa 23521 aggaaagacc cagcttccaa tagctgatgc ctcttaaatt cagctcttta atcagattga 23581 attttgcttg aatcgagcgg gcatcctcga accatacctc gtgccttctg ttttctgcat 23641 cagtatagcg gaagaaagga gcttgagcgg tttggtcata ctgaatggaa gcattgttct 23701 gatcagctat gacaatggct tgctgagggc ttactgctct tgctggagtt ccccctgctg 23761 tatatggcag cgtccagtca tatccatata aattctggcc catgacaatt ttgttcgcag 23821 gcatttcagt caaagcatat tctatgacat cacggacagg tccaattgga gaaaccgctt 23881 gaggcggtcc gccgctatag ccccattcat atgtcatgag aacaacaaag tcgacaattt 23941 cgccatgtgc cctgtaatca tgagcttcat accacctgcc ctgctgtgtt gcacttgttt 24001 taggagcaag agccgtagaa atttctaagc cctctcgatg gaaaagatcc cttgcttcgc 24061 ggaggaattg attataggcc tctctatcct ggggccgcaa atattcaaag tcgaaatgaa 24121 tgtcacggaa gccatatctt ctggcattct cgactatttc atttagaagc cgtcttttta 24181 cagtttcgtc gttcaaaagg atccggccaa gttcatcgct gaatgcctgg ttttctaggt 24241 tcgttataat catcatcaat gttgtatttt gactttctgt aatgctcctt aaattcgtta 24301 aaggcggtgc gactaaggtt ccgttccgct gtgcctggaa gctgaatgcg ccaaggtaag 24361 ttaagtaggg cgacgcttct ctggccgcct gctggagatt ttcgctgact tgatttcctc 24421 ggggctccaa ataagcattt gattcgatgt ctcgtttagg agctggaggg atgtataaac 24481 ggaaaccaat ctgaagcacg gtatttaact ggatgcggtt aacccttgcg agctcggctg 24541 ctgttgtatt gaactgccgg gcgatggatg tcagggtatc acctcgcttc acatcataga 24601 actggccagc tattggaatg acaatggttt gtccgacaac aaggctgtcg ggattcggta 24661 tttcattcgt ttcagtgatg tcatttgtgg ttgttctgta ttgtgaagcg atagcagaaa 24721 gagtgtcgcc ttgttttacc acataaattt gaatgaaaaa cgcctccttt catatcgcta 24781 tcaatgtatg aaagaaaagc gctgatcatg tttatttttc tataatttgt tcttccgtcg 24841 taatttctgc gaaaagaaca ttctccatca tggttaaggc gaattcgtta tcttcgtcac 24901 tgtttgacgc gatacagtcc ttaggaatcg tgatgctgta ttccctcata taagcgtcat 24961 tagcggtaaa cagcacgcat atattgccgg ctatacctgt tatgataata tgtctcacct 25021 gcaactcagt aagaagggtg tgaagtgctg tttcgtagaa agcggaatgt ttcggtttga 25081 ttaaaaaata atcagcatct accggagcta tctttgtgat gatatccttg cttctttcat 25141 ttgtgcattc ttgctgtatg tttttaatgt cagcttgcca aagtccataa tgatcattga 25201 tgtaaataat cggccattca ttttgtctcg cgtgctcctt taatgataaa atatgaggaa 25261 cgattttttc tgttttttta gcgagggttt cccccatatc gaattcaaaa ttattgatca 25321 tgtctacaat gagaagggct ttatctgctt tggacaatcg acagtctcct ttccgtttca 25381 gttatagtta atatgtagcc tttttaggca atgaaaaaac tttgaaaaga gagcttatcc 25441 ttatgacaca agatgaactt tatatgaaag aagcaattaa agaagcgaaa aaggctgaag 25501 agaaaggtga agtgccaata ggtgcggtgc ttgtcattaa tggtgaaatt atagcgcgtg 25561 cgcataattt aagagagact gaacagcgat ctattgccca tgcagaaatg cttgtaattg 25621 atgaagcgtg taaggcactc ggaacatggc ggctggaagg tgcgactctt tatgtgacgc 25681 ttgagccttg tccaatgtgt gctggtgcag tcgtactttc tcgagtggaa aaagtggttt 25741 ttggcgcatt tgatccgaaa ggcggctgtt caggcacgct aatgaacctt cttcaggagg 25801 aacgctttaa tcatcaggct gaagtggtga gcggtgtgct tgaggaagaa tgcggcggaa 25861 tgctcagtgc gtttttcaga gaactaagaa aaaagaagaa agccgccagg aaaaacttgt 25921 ctgaatagta cggttgcaat ttttagggga aacagatata cttaagtgtg catcgtaata 25981 gatgcaacat aaaatttgat atttattttg ccgtgctaag cggggaggta gcggtgccct 26041 gtacctgcaa tccgctctag cagggccgaa tcccttctcg aggttcgttt actttaaggc 26101 ctgccttaag taagtggtgt tgacgtttgg gtcctgcgca atgggaattc atgaaccatg 26161 tcaggtccgg aaggaagcag cattaagtga aacctctcat gtgccgcagg gttgcctggg 26221 ccgagctaac tgcttaagta acgcttaggg tagcgaatcg acagaaggtg cacggtaaat 26281 caatcatcaa attttcagac tcacctaata ttaggtgagt tttttgttat gtaaaaagag 26341 cttttggaat cgaaacaagg ttcatgtata atgggaatga tgaataacgg aggagggcaa 26401 acccgtgagt taccaagctt tatatcgagt attcaggcct cagcgctttg aagatgtggt 26461 cggacaagaa cacattacaa aaacgctgca aaatgccctt ttgcaaaaaa agttttctca 26521 cgcctatctg ttttccgggc ctagaggaac cggaaaaacc agtgcagcca aaatatttgc 26581 taaggctgtc aactgtgaac atgctcctgt tgatgagcca tgcaacgaat gtgcggcctg 26641 taaagggata acaaacgggt caatatccga tgtcatagaa attgacgccg cttctaataa 26701 cggtgttgat gagattcgtg acattcgcga taaagtgaag tttgccccat cggccgtcac 26761 atataaggta tatatcatag atgaggtgca tatgctttct atcggcgctt ttaatgcatt 26821 actaaaaaca ttagaagagc cgcctgagca ttgtattttc atattagcaa caactgaacc 26881 gcacaaaatt cctttaacca ttatctctag atgtcagcgt tttgacttta aacgaattac 26941 ctcccaagcg attgtaggcc gcatgaataa aattgttgat gctgaacagc tgcaagtgga 27001 ggaaggatcg ctggaaatca tcgcgagtgc tgcagacgga gggatgaggg atgccctgag 27061 ccttcttgat caggccatat cattcagcgg cgatatcctg aaagtcgaag atgcgctttt 27121 aattacgggt gctgtttctc aattatatat cgggaagctt gcaaaatccc tgcatgataa 27181 aaacgtttct gacgcactgg aaacattaaa tgaattgctt cagcaaggaa aagatccagc 27241 taagctgata gaagatatga ttttctattt cagggacatg ctgctgtaca aaacagcccc 27301 tggcttagag ggagtgcttg agaaagtaaa agtcgatgaa acgttccggg aactaagtga 27361 acaaattccg gctcaggccc tatatgaaat gattgatatt ctgaacaaga gccatcagga 27421 aatgaaatgg acaaatcatc cgcgtatctt tttcgaagtg gccgttgtga agatttgcca 27481 aacctcacat caatctgctg ctgatctccc ggaagtggat atgctgatga aaaaaatcca 27541 gcagctcgaa caggaagtag agcggctcaa aacaacgggc ataaaagcag ctgcggaaag 27601 cccgaaaaaa gaagcgccgc gtgtgccaaa gggcgggaaa tccaattaca aagcgccagt 27661 aggcagaatt catgagattt tgaaggaagc cacaagaccg gatcttgatc tgctcagaaa 27721 cagttggggc aagcttcttg ctcatctcaa acagcaaaac aaagtatcac atgccgcttt 27781 gctgaatgac agtgaacctg tggctgccgg atcggcggca tttgttctga aattcaaata 27841 tgaaattcat tgtaaaatgg tcgctgagga taacaacgga gtccggacta atcttgagca 27901 gattttagaa tcgatgctcg gaaaaagaat ggatttgatt ggcgttccag aagcacaatg 27961 gggtaaaata agagaagaat ttttagaaga tcatcagcag gaaaatgaag gatcaaatga 28021 accggctgaa gaagacccgc ttattgccga agcgaaaaag cttgttggag cggatttaat 28081 tgaaataaaa gactaacaaa atgaaagaga gtgaatgcta tgcgtggcgg aatgggtaat 28141 atgcaaaaaa tgatgaaaca aatgcaaaaa atgcaaaagg acatggcgaa ggctcaagaa 28201 gagcttgcag aaaaggttgt tgaaggaact gcaggcggcg gtatggtaac agtaaaagca 28261 aacggccaaa aagaaatcct ggatgttatc atcaaagaag aagtcgttga tcctgaagat 28321 attgatatgc ttcaagattt agtgcttgct gcaacgaatg aagctttgaa aaaagttgac 28381 gaaatcacaa acgaaacaat gggtcaattt acaaagggaa tgaacatgcc aggtttattc 28441 tagggggata aaagaacatg caatatcctg aaccaatatc aaagctgatt gacagcttta 28501 tgaaattgcc agggatcgga ccgaaaacag cggttcgtct ggcttttttt gttctaggta 28561 tgaaagaaga tgtagtatta gattttgcga aagcattagt aaatgcgaaa cgcaacctga 28621 catattgttc agtttgcggg catattacag atcaggaccc ttgctatata tgtgaagata 28681 cgcgcaggga taagtctgtt atctgtgttg tgcaagaccc taaagacgtt atcgctatgg 28741 agaaaatgaa ggaatacaac ggacagtatc acgttcttca cggcgctatt tctccaatgg 28801 acggcatcgg accggaggat attaaaatac cagaattgtt aaaacgatta caggatgatc 28861 aagtgacaga agtgatcctc gcgacaaacc ctaatataga aggggaagca acagcgatgt 28921 atatatcaag gctcctcaag ccgtctggta ttaagctctc ccgtattgcc cacggactgc 28981 ccgtcggcgg tgatttggaa tatgctgatg aggtcactct ttctaaagca cttgaaggaa 29041 gacgtgaatt gtaaggagga aaaagcgatc catgggtttt cttcgcaaga aaacattaag 29101 aagagagttt gatgaaaaac taaccgagca gctttttaag caaaaggaag agtggaacag 29161 gcaaaaaaag ctggttgaaa aaagcttaga accgtctgct gaagtgttat acgaactgaa 29221 agtagctgaa gcgaagtatt ttttttactt aagggaagcg aagcagcgaa atttaaaaat 29281 cagccggtgg aagtaagtgg tctaaactcc tggatcttct cataagcttg tactagaaca 29341 agcgaaggag atgagaagat tcatggagcc tatttttatt attgggatta ttttaggact 29401 ggttattctt ctttttttat caggttcagc agcgaagcct ttaaagtgga ttggcatcac 29461 agctgttaaa tttgtggcag gtgctttgct gctggtttgt gtaaatatgt ttggcggcag 29521 tcttggcatt catgtgccga ttaatctggt tacaacagct atcagcggaa ttttaggaat 29581 acccggaata gctgcgttag tcgtcattaa gcaatttatc atttaattga tattatgtat 29641 tgacttagac aactgaaggt gttattctaa tatacgtcgc tgatgacgaa cagctttttt 29701 gaaaagaaaa tgctaaaaag ttgttgacag tagcggcggt aaatgttatg ataataaagt 29761 cgcttaaacg agcggtaaac aaagttcttt gaaaactaaa caagacaaaa cgtacctgtt 29821 aattcatttt tataaatcgc acagcaatgt gcgtagtcag tcaaactact ttatcggaga 29881 gtttgatcct ggctcaggac gaacgctggc ggcgtgccta atacatgcaa gtcgagcgga 29941 cagatgggag cttgctccct gatgttagcg gcggacgggt gagtaacacg tgggtaacct 30001 gcctgtaaga ctgggataac tccgggaaac cggggctaat accggatggt tgtttgaacc 30061 gcatggttca aacataaaag gtggcttcgg ctaccactta cagatggacc cgcggcgcat 30121 tagctagttg gtgaggtaac ggctcaccaa ggcgacgatg cgtagccgac ctgagagggt 30181 gatcggccac actgggactg agacacggcc cagactccta cgggaggcag cagtagggaa 30241 tcttccgcaa tggacgaaag tctgacggag caacgccgcg tgagtgatga aggttttcgg 30301 atcgtaaagc tctgttgtta gggaagaaca agtaccgttc gaatagggcg gtaccttgac 30361 ggtacctaac cagaaagcca cggctaacta cgtgccagca gccgcggtaa tacgtaggtg 30421 gcaagcgttg tccggaatta ttgggcgtaa agggctcgca ggcggtttct taagtctgat 30481 gtgaaagccc ccggctcaac cggggagggt cattggaaac tggggaactt gagtgcagaa 30541 gaggagagtg gaattccacg tgtagcggtg aaatgcgtag agatgtggag gaacaccagt 30601 ggcgaaggcg actctctggt ctgtaactga cgctgaggag cgaaagcgtg gggagcgaac 30661 aggattagat accctggtag tccacgccgt aaacgatgag tgctaagtgt tagggggttt 30721 ccgcccctta gtgctgcagc taacgcatta agcactccgc ctggggagta cggtcgcaag 30781 actgaaactc aaaggaattg acgggggccc gcacaagcgg tggagcatgt ggtttaattc 30841 gaagcaacgc gaagaacctt accaggtctt gacatcctct gacaatccta gagataggac 30901 gtccccttcg ggggcagagt gacaggtggt gcatggttgt cgtcagctcg tgtcgtgaga 30961 tgttgggtta agtcccgcaa cgagcgcaac ccttgatctt agttgccagc attcagttgg 31021 gcactctaag gtgactgccg gtgacaaacc ggaggaaggt ggggatgacg tcaaatcatc 31081 atgcccctta tgacctgggc tacacacgtg ctacaatgga cagaacaaag ggcagcgaaa 31141 ccgcgaggtt aagccaatcc cacaaatctg ttctcagttc ggatcgcagt ctgcaactcg 31201 actgcgtgaa gctggaatcg ctagtaatcg cggatcagca tgccgcggtg aatacgttcc 31261 cgggccttgt acacaccgcc cgtcacacca cgagagtttg taacacccga agtcggtgag 31321 gtaacctttt aggagccagc cgccgaaggt gggacagatg attggggtga agtcgtaaca 31381 aggtagccgt atcggaaggt gcggctggat cacctccttt ctaaggatat tttacggaat 31441 ataagacctt gggtcttata aacagaacgt tccctgtctt gtttagtttt gaaggaactt 31501 tgttccttga ataagttaag atgggcctgt agctcagctg gttagagcgc acgcctgata 31561 agcgtgaggt cggtggttcg agtccactca ggcccaccat cttatataac ggggccttag 31621 ctcagctggg agagcgcctg ctttgcacgc aggaggtcag cggttcgatc ccgctaggct 31681 ccaccaacgt gttctttgaa aactagataa cagtagacat cacattcaat tagtaacaca 31741 agatatcaca tagtgattct ttttaacggt taagttagaa agggcgcacg gtggatgcct 31801 tggcactagg agccgatgaa ggacgggacg aacaccgata tgcttcgggg agctgtaagc 31861 aagctttgat ccggagattt ccgaatgggg aaacccacca ctcgtaatgg agtggtatcc 31921 atatctgaat tcataggata tgagaaggca gacccgggga actgaaacat ctaagtaccc 31981 ggaggaagag aaagcaaatg cgattccctg agtagcggcg agcgaaacgg gattagccca 32041 aaccaagagg cttgcctctt ggggttgtag gacactctgt acggagttac aaaggaacga 32101 ggtagatgaa gaggtctgga aaggcccgcc ataggaggta acagccctgt agtcaaaact 32161 tcgttctctc ctgagtggat cctgagtacg gcggaacacg tgaaattccg tcggaatccg 32221 ggaggaccat ctcccaaggc taaatactcc ctagtgaccg atagtgaacc agtaccgtga 32281 gggaaaggtg aaaagcaccc cggaagggga gtgaaagaga tcctgaaacc gtgtgcctac 32341 aagtagtcag agcccgttaa cgggtgatgg cgtgcctttt gtagaatgaa ccggcgagtt 32401 acgatcccgt gcaaggttaa gcagaagatg cggagccgca gcgaaagcga gtctgaatag 32461 ggcgcatgag tacgtggtcg tagacccgaa accaggtgat ctacccatgt ccagggtgaa 32521 gttcaggtaa cactgaatgg aggcccgaac ccacgcacgt tgaaaagtgc ggggatgagg 32581 tgtgggtagg ggtgaaatgc caatcgaacc tggagatagc tggttctctc cgaaatagct 32641 ttagggctag cctcaaggta agagtcttgg aggtagagca ctgattggac taggggcccc 32701 taccgggtta ccgaattcag tcaaactccg aatgccaatg acttatcctt gggagtcaga 32761 ctgcgagtga taagatccgt agtcgaaagg gaaacagccc agaccgccag ctaaggtccc 32821 aaagtatacg ttaagtggaa aaggatgtgg agttgcttag acaaccagga tgttggctta 32881 gaagcagcca ccatttaaag agtgcgtaat agctcactgg tcgagtgact ctgcgccgaa 32941 aatgtaccgg ggctaaacgt atcaccgaag ctgcggactg ttcttcgaac agtggtagga 33001 gagcgttcta agggctgtga agccagaccg gaaggactgg tggagcgctt agaagtgaga 33061 atgccggtat gagtagcgaa agaggggtga gaatcccctc caccgaatgc ctaaggtttc 33121 ctgaggaagg ctcgtccgct cagggttagt cgggacctaa gccgaggccg aaaggcgtag 33181 gcgatggaca acaggttgat attcctgtac cacctcctca ccatttgagc aatgggggga 33241 cgcaggagga tagggtaagc gcggtattgg atatccgcgt ccaagcagtt aggctgggaa 33301 ataggcaaat ccgtttccca taaggctgag ctgtgatggc gagcgaaata tagtagcgaa 33361 gttcctgatt ccacactgcc aagaaaagcc tctagcgagg tgagaggtgc ccgtaccgca 33421 aaccgacaca ggtaggcgag gagagaatcc taaggtgatc gagagaactc tcgttaagga 33481 actcggcaaa atgaccccgt aacttcggga gaaggggtgc tctgttaggg tgcaagcccg 33541 agagagccgc agtgaatagg cccaggcgac tgtttagcaa aaacacaggt ctctgcgaag 33601 ccgtaaggcg aagtataggg gctgacgcct gcccggtgct ggaaggttaa gaggagcgct 33661 tagcgtaagc gaaggtgcga attgaagccc cagtaaacgg cggccgtaac tataacggtc 33721 ctaaggtagc gaaattcctt gtcgggtaag ttccgacccg cacgaaaggc gcaacgatct 33781 gggcactgtc tcaacgagag actcggtgaa attatagtac ctgtgaagat gcaggttacc 33841 cgcgacagga cggaaagacc ccgtggagct ttactgcagc ctgatattga atgttggtac 33901 agcttgtaca ggataggtag gagccttgga aaccggagcg ccagcttcgg tggaggcatc 33961 ggtgggatac taccctggct gtattgacct tctaacccgc cgcccttatc gggcggggag 34021 acagtgtcag gtgggcagtt tgactggggc ggtcgcctcc taaaaggtaa cggaggcgcc 34081 caaaggttcc ctcagaatgg ttggaaatca ttcgcagagt gtaaaggcac aagggagctt 34141 gactgcgaga cctacaagtc gagcagggac gaaagtcggg cttagtgatc cggtggttcc 34201 gcatggaagg gccatcgctc aacggataaa agctaccccg gggataacag gcttatctcc 34261 cccaagagtc cacatcgacg gggaggtttg gcacctcgat gtcggctcat cgcatcctgg 34321 ggctgtagtc agtcccaagg gttgggctgt tcgcccatta aagcggtacg cgagctgggt 34381 tcagaacgtc gtgagacagt tcggtcccta tccgtcgcgg gcgcaggaaa tttgagagga 34441 gctgtcctta gtacgagagg accgggatgg acgcaccgct ggtgtaccag ttgttctgcc 34501 aagggcatcg ctgggtagct atgtgcggac gggataagtg ctgaaagcat ctaagcatga 34561 agcccccctc aagatgagat ttcccattcc gcaaggaagt aagatccctg aaagatgatc 34621 aggttgatag gtctgaggtg gaagtgtggc gacacatgga gctgacagat actaatcgat 34681 cgaggactta accacatttt gaatgatgtc acacctgtta tctagttttg agagaacacc 34741 tctctaaagg cggaaggtaa ggaaactccg ctaagggctc tcacatcctg tgagaaacgc 34801 ccagtacctt catcctgaag gcatttgttt ggtggcgata gcgaagaggt cacacccgtt 34861 cccataccga acacggaagt taagctcttc agcgccgatg gtagtcgggg gtttccccct 34921 gtgagagtag gacgccgcca agcaagctta aacccagctt aatgagctgg gttttttgtt 34981 tactcaagat cgagaaaatc aaacaaatac aaacaccgag ggcttatata gcccatatac 35041 tgatttaaag tttcaaaaag gtctaaatag tgtatacaat atccgtttta aggggaggct 35101 aactgtacgg aggtggagaa gatggacgaa acagttaaac ttaatcatac atgtgtgatt 35161 tgtgatcaag agaagaatag aggcattcat ctttatacga aattcatatg cttagattgt 35221 gagagaaaag taatttctac atcaacttct gatcctgact atgcgtttta cgtaaaaaaa 35281 ctaaagagca ttcatacacc gccattatat tcatagacct gaaaaggtct ttttttgtac 35341 tcttaataat aaaaagaaga tgaaacttgt ttaaggattg aacgtagtag ataataatat 35401 taaaactgag tatagacaca ggagtcgatt atctcatgca gagatttttt cactttttgg 35461 tgtggagttt aactagcagt gcgacttttg ttttcattgg aatattgagc ttttttggtt 35521 taaaccagtc gattttttta tctattgttt atgggcttgc ttctggagca gccgtatata 35581 tagctggcat ctggaatgca agacggttat ttcttaaaaa gcatgaattg acaggaagag 35641 agtatgctta cattaagaaa aacttagagg aagcaaggca gaaaatggtc cgtcttagga 35701 aagccttgtt tcaggctaaa agcattcaaa tgtttaagca aaatgcagaa atgctaagga 35761 ttgtgagaag gatttatctc ctcaccaaaa aagagccaaa gcggttttat caggcagaac 35821 gattttttta tcaaactctc gattcggttg ttgaattgac agagaagtat gcttttctat 35881 catctcaccc aaaaaaaagc aaagaactgt cgatgtcgtt aagtgagaca cgcatcactc 35941 ttactgaatt gaccaagcgt ttagaggaag atttaactca agcaatgggt gatgaaattg 36001 acgagttgca gtttgaatta gacgcagcaa aacattcatt aaagaaataa gggaagaggg 36061 taagagcgat gaaccgagac caaagcgacc ttcatataga tgaattattg gcagatcctt 36121 ttggtggtaa catagagata ccaggttcgg aggctgtaaa agcagagaaa gagcaagtac 36181 ggcttgttga tgttcttcct gaggaaaaca aggaaaaagc aattcagctt gctggacaga 36241 ttgatcataa aaatatgcaa agcattgtct tatacggttc acaagctcaa tctaaactgc 36301 tgaacttttc tcatgatatg attaatcatg ttcaaaagaa ggatgtcggg gagattggcg 36361 aaatacttgg agagctgatg aaaaagctgg agcaagtaaa tcctgatgat ctccaatcta 36421 agaaaaaggg ttttttggca cgcatgtttg gaagagtatc aagttctctt caagaggtgc 36481 tgtctaaata ccaaaagacc agtgtgcaga tagacagaat cagcttgaag ctggagcact 36541 ctaaaaatgc tttaatcagt gacaacaagc tgttagagca gttatatgaa aaaaataaag 36601 aatatttcgc agcgctgaat gtttatattg ctgcaggaga actgaagctg gaggaattaa 36661 aaacaaaaac gattcctgaa ctgaagcaac aggctgaatc gagtgatcat aaccaaatgg 36721 ccgttcaaga ggtgaatgat ttaattcaat ttgctgaccg gttagataaa agggtgcatg 36781 atttgctgct gagcaggcaa attacaatcc aaagtgcacc gcaaatcagg ctgattcaaa 36841 atacaaacca agcgttagct gaaaagattc agtcatccat tgtgacagcg attccgttat 36901 ggaaaaatca agttgccatt gcactgacgc ttttaaggca gcgcaatgca gtggatgcac 36961 agcagaaagt atctgataca accaatgagc ttttgctgaa aaatgcggag cttttaaaaa 37021 ccaatacaat tgaaactgca cgggcaaatg aaagaggcct tgttgatata gataccttga 37081 agaaggtgca ggaaagctta ataagcacgc ttgaagaaac actgactata caagaagaag 37141 gacgaatcaa acgccgtcag gcagaagaag agctcatgat gatggaaggc gacctgaagc 37201 aaaagctgat tacaataaag gaaagatgat taccagtaag tctggcttta agttctgtca 37261 gaggcacgat ataataaggt gtaagaagac acattcaaag gattgttttc atgaacacac 37321 ctttatataa agcattaatt caacatgcga gaagaaattc tcattcattt catgttccgg 37381 gacatcacaa tggagatgtc ttttttgatg acgctaagtc aatattcgat ccgcttctca 37441 ccattgatgt aactgaactg gcaggactgg atgatctcca tcatccttct ggggtgatta 37501 aggaagctca ggagcttgcc agtcaattat atggatcggc ggaaagtttt tttctggtaa 37561 atggtacgac tgtcggaaac ttagcgatga ttttatctgt ttgtgaacct ggtgatacaa 37621 ttctggttca aagaaactgt cataaatctg tatttcatgc tgttgatttg tccggtgctg 37681 agccggttta tcttgcacct gacgttgatt cagcgatgca tgtgcctacg catgttccgc 37741 ttggaacaat taaagaggcc ctggaagcat atccagatgc gaaaggcttg gtactgacca 37801 atccgacata ttacggacat agtgctgatt tgactgagat cattactgaa gcccatcatt 37861 acgggattcc tgttttggtc gatgaagcgc atggcgcaca ttttatttta ggtgagcctt 37921 ttccggtctc agctttaaaa atgggggcag atattgttgt tcagtcggcc cacaaaacgt 37981 tgccagccat gacgatgggt tcttatttgc atctcaacag cagctgcagg attaacaggg 38041 atcgggtggc agagtattta aaccgattac aaagcagcag cccgtcttat ccgattatgg 38101 cttcgttaga tattgcccgc gcttatgtac agcatattat agaagaacaa aagctttctg 38161 acattctgca gcggatagaa acacttaaac aaacgtttga ttcacttaca aatgcagaag 38221 ctgttaaccc tgctaatcca ctgatcatca cggatccgct aaagctcaca attcgttcaa 38281 aacgcgggca ttctggctat acgctgcaaa gcattttaga gcgtgccaac atattcactg 38341 agcttgctga tgaaaatcaa gttctgctcg ttctcccatt gggaggaaaa cggagaataa 38401 acgctgaaat cattagaagc atcgatgaag agattgagaa aacgcctccg gatcagacgt 38461 ttgtttctgc agaatggggt gtgcagcctg ttactgtctt gccttatcca aaaaaggtct 38521 tacattcgtt taagaaagaa tatgtgagct ttgaggaagc agctggccgg cttaatgcag 38581 aagatatcat cccttatcct ccgggtatcc cgatgattat ggcgggagaa agaataacaa 38641 aagaaagtgt gcaaaagctc agccgcttga tcagcatgaa aacgcatgtt caagggaata 38701 tgaaaatcaa agagaaacaa ctacttgttt atatagaaga ggagaaatca tgagcggttt 38761 atttattaca ttcgaaggtc ctgaaggtgc agggaaaacg actgttctgc aggagatcaa 38821 aaacatactg acagcagaag gccttcaggt tatggcaact cgagagccag gcggaataga 38881 tattgcagaa caaattagag aggttattct gaatgagaac aatatattaa tggacccaaa 38941 aacagaagct ctcttatatg cggctgcaag acgccagcat ttagttgaaa aagtaaaacc 39001 tgctttagaa caggggttta tcgttctttg cgacagattc atagacagtt ctcttgcgta 39061 tcaaggatat gcaagagggc ttggaattga tgaggttctg tccattaatg aatttgccat 39121 tggagatatg atgccccatg taacggttta tttttcaatt gatccggaag aaggactgaa 39181 gcgtatttac gcaaacggct cacgggagaa aaacaggctc gatttagaaa aactggactt 39241 tcatacaaaa gtacaagaag gttatcaaga gctgatgaag cgatttccgg aaagatttca 39301 ttcagttgat gccgggcaat ccaaagacct cgtcgttcag gatgttctaa aggtgatcga 39361 tgaagcgttg aaaaaaattc aattgtgacc tgtttcccaa tagttgatat aataatgtaa 39421 acgagatcac gttgtttcca atctaaagga ggccttcaca gatgaaattg atagtggcag 39481 ttgtacaaga tcaggacagc aacagacttt tgaaaacctt aacggatcac aacttcagag 39541 tcacaaagct tgcaacgaca ggaggatttc ttaaatcagg caatacaacg tttatgatcg 39601 gtgtcgagga tatacgcgtc aataaagcgt tgagtctcat taaagaaaac gggcagaaac 39661 gtgatcagat gattgcccct gtatctccaa tgggtggaaa tgctgattcc tatgtccctt 39721 atccagtcga agttgaagtt ggcggagcga cagtatttgt ccttccagtc gatgaatttc 39781 atcaatttta aggatctgaa actgtgaaaa ttaataaaga tatacgtaca tttatagata 39841 ataagcagat tccctctgtg aaaacatctg agatcacagc atcgtttaaa acatcaatgg 39901 aaaaccaaag cagcaaaatg aagcttgatc agcttaccag gctgttatct gatatagaag 39961 catttggaaa aaggctaacg aaatctcgga attttaaaga cttagcgaga tttaaaggac 40021 ttgtgaaacg ttttgtcaaa gaagctgtgg acagcggtct ttcacatgaa acatcgaaaa 40081 gctttgacct ttacgggaac agcagaacgc tgggacttgt gaaagaaata gatgacaaat 40141 tgatacagct tacggaagag atgatggatc aggaaaaacc ggcaattgat ttgctggagc 40201 gtattggcga aataaaaggt ttattaatta acctttacac atagagagtg atacaatggc 40261 aatatcctgg aaggaaatga acgagcttca gcccagagtg atgaagcttt tatataatag 40321 tattgagaag gacagactat cacacgctta tttgtttgag gggaaaaaag gaacaggcaa 40381 gcttgatgcc gcgctgcttc ttgcaaaaag cttcttttgt ctggagggtg gcgcggagcc 40441 ttgtgagagc tgccgaaact gtaaacggat agagtcaggg aaccatcctg atctccatct 40501 tgttcagcct gatggcttat caatcaaaaa ggcgcaaatt caagcgctcc aagaagagtt 40561 ttctaagaca ggacttgaat cgcataaaaa gctgtatatt atttcgcacg cagatcaaat 40621 gacagcaaat gcggcgaaca gcctgctgaa atttttagaa gaaccgaaca aagacacaat 40681 ggccgtcctc atcactgagc agccccaaag gttattggat accatcattt caagatgcca 40741 aacccttcct tttcagcctt tgcagccgaa agcaattgaa gacagactga tcgaacagga 40801 cgtctcgcct catatggcaa ggcttctggc caacatgact aataatgtag cagaagcagt 40861 cgaattaagt cgaaatgatg agtttgcaga gtctagagcg aaagtgataa aattgtatga 40921 agtcctacac cagcggaaag gacatgcttt tttctttatt caagatcaat ggatgccctt 40981 tttcaaagaa aaaacccatc aagaaatggg tcttgatatg ctcttattga tatatcgtga 41041 tgtgttgtcc atccaaatag gaaatgaaga taaattgatt tatcaagact tattccaatc 41101 aataaaacag catgcgctac aatcaacaca acaaagcgtt acgaatcaga tacttgctgt 41161 tttagaagca aagaaacggc ttcattccaa tgtgaatgta caaggattaa tggagcactt 41221 ggtgttaatg ttgcaggagg gataagcttg tacaatgtaa ttggtgtccg ctttaagaaa 41281 gcgggtaaaa tatattattt tgatccgaat ggatttcata tagaacatga cagctgcgta 41341 attgtagaaa ctgtcagagg cgttgagtac ggccaggtcg taattgcaaa taaacaggtg 41401 gatgagcatg atgtggtgct tccccttcga aaagtgatac gtgtggcaga cgatcgcgat 41461 cttctcattg tagaagaaaa taaacaggaa gcactatcag catttgatat ctgccaaaag 41521 aaagtgattg agcatggctt ggatatgaag ctggtcgatg ttgaattcac gtttgatcgc 41581 aataaagtca ttttttactt cactgctgac ggccgagtcg actttagaga gcttgtaaag 41641 gatttggctt ctatctttaa gacaagaatt gagctgcgcc aaatcggagt gagggatgag 41701 gcaaaaatgc tcggaggaat cggtccttgc ggaagaatgc tttgctgttc aacgtttctt 41761 ggagattttg aacccgtttc cattaaaatg gccaaggatc agaacttgtc tttaaatcct 41821 acgaagattt cgggtctttg cggacgattg atgtgctgtc taaaatatga gaacgatgag 41881 tatgagacgg caaaagaaca gcttccggat ataggagaaa tgattacgac agcaaacggt 41941 cccgcgaagg tcgtcggact aaatattctg gaacgggtgc ttcaggtgga actgataaac 42001 cgtgaaaaag tgatagaata tacttgggaa gagctcttgg aagagggcgt cgtatccgca 42061 caaaccacag attaacgagg tgtggaacct tggataaaaa agagttattt gatacagtca 42121 ttaacttaga agaacaaatt ggctcactgt accggcagct gggggatttg aagcagcata 42181 tcggtgagat gattgaggaa aatcatcatt tacagcttga aaacaagcat ttgcgcaaac 42241 ggctggacga tacgacgcag cagattgaaa agttcaaagc tgataaaaaa gaatcaaaaa 42301 cacagaagac agagcaaact gatatagggg aaggatatga taatctggca cgtctgtatc 42361 aagaaggatt tcatatctgc aatgtccact atggaagtgt tcgaaaagag gattgtcttt 42421 tctgtctgtc attcttaaat aaaaaatagg gaaaaggctt ccgcataaga cgggagcctt 42481 tttcaaaggt actgaaagga taagaagatg gtttcattac atgatgatga aagattagat 42541 tatttgctgg cagaggacat gaaaatcata caaagcccaa cagtgtttgc tttttcgttg 42601 gacgctgtgc ttctgtccaa atttgcgtac gttccgattc aaaaagggaa aattgttgat 42661 ttatgcaccg gcaatggtat tgtgccgctg ctgctcagta caagatcaaa agcagacatt 42721 ctgggagtcg aaattcaaga aagactgcat gatatggctg ttcgcagcgt ggagtataat 42781 aagttggacg atcagatcca gatcatacat gatgacctga aaaacatgcc ggagaaactt 42841 ggacataatc gatatgatgt tgtcacctgc aatccgccgt attttaaaac gccgaaacaa 42901 actgaacaaa acatgaacga gcatctccga atcgcaagac atgaaatcca ctgcacgctg 42961 gaggatgtca tttcagtcag cagcaagctg ctcaagcaag ggggaaaagc agctcttgtt 43021 caccggccgg gaaggcttct ggagattttt gaactgatga aggcttatca aatcgagccg 43081 aaacgtgtac aatttgtcta tccgaagcaa gggaaagaag ccaataccat tttggttgaa 43141 ggtatcaaag gcgggcgccc ggatttgaaa attcttcctc ccttattcgt atatgatgaa 43201 caaaatgaat atacaaaaga aatcaggacc attttatatg gagacaaata accatttctt 43261 ctacgtcgtg aaatgtaagg acaatagctg gtatgccggg tataccaacg atctgcataa 43321 acgagtgaaa acgcacaatg atggaaaggg cgcaaagtac acaaaagtaa gacgtccggt 43381 tgaattaatt tttgccgaga gcttttcaac aaagcgggaa gctatgcagg cggaatatta 43441 tttcaaaaaa ctaactcgga agaaaaaaga gctttatata gaagaaaagc ggaacagcaa 43501 ggaggctgta tatgttaagg cgccaaatga gctttaatgg aaagtcggac atggggattc 43561 tttacttggt cccaacccca atcggaaatt tagaggatat gacattccgg gcgatcgaca 43621 cgctgaaatc agtggatgcg attgctgcgg aagatacgag gcaaacgaaa aagctttgtc 43681 atgtatatga aattgaaaca ccgctcgtca gctatcacga acacaataaa gaaagcagtg 43741 ggcacaaaat tattgaatgg ctgaaatcgg gaaaaaacat tgctcttgtc agtgatgccg 43801 gtctgccgac gatttctgat cccggagcgg aaattgtaaa ggattttacg gatataggcg 43861 gttatgttgt tccgttgccg ggagcaaatg ctgcattaac agctcttatt gcttcaggta 43921 ttgtaccgca gccttttttc ttttacggtt ttctcaacag acagaaaaaa gaaaagaaga 43981 aggagcttga agcccttaaa aaacggcagg aaacgatcat tttttatgaa gcgccccaca 44041 gattgaagga aaccttgtca gcgatggcag agatattagg agatcgggaa attgctgtaa 44101 cacgtgaact cactaagaaa tatgaagagt ttatccgagg aaccatatct gaggtcattg 44161 gatgggcaaa cgaggatcag atacgcggcg agttttgtct tgtcgtagaa ggaagtaata 44221 atgaagaggt agatgaggaa gaacaatggt gggaaaccct cactgcgaaa gaacatgtcg 44281 agcattacat ttcgaaaggc gctacgtcta aagaagctat taaaaaagca gcagtcgatc 44341 gcaatgtacc aaagcgtgaa gtgtacgatg cttaccatat taagcaataa aaaaacgttc 44401 ttgtgtcata acaagaacgt tttttgtaca agaaatgatt atttaaggtt ttgaagctgg 44461 ttttggattt cgctgatgat ttgctcagcg ccttctttac taagaaccaa tttaccgcct 44521 gcaagtttaa ggttatcatc agaaacttca ccagttactt ggcaagtcat gtttggttta 44581 tattttttaa ggatgatttt ttcatcatca acatagattt caagagcatc tttttctgcg 44641 attccaagag tacgacgcag ttcgatagga ataactacac gtcctaattc atcaacttta 44701 cgtacaatac cagtagattt cataaacatt ctcctcccaa gagatactta tttgtttaaa 44761 ttatattttt cttcgtcatt attcgacaaa atccttacct tcatagcata acaaggtttc 44821 caataatcgt caatcatttt gtttactatt gattgtaaga attagttctt atagtcagta 44881 atgtcttgga aactaccgaa ataacagcat tttataaata tttaataaag ctattatcct 44941 actaaaaatc cttttaaatc aagactttcg aaccaaagtt ttttatttca tttgattata 45001 tacgacaaaa ttcgacacga acagactttt tttattttca ttaaagattt ttaattttaa 45061 ttattctttt tcagggcgta tgtatatatt cttgatctta aaggctaaga tggtatcata 45121 gataaaggat aaatataaat aatattcata tatgatttgc acttatcgcc gctctcgtcc 45181 tttgggcggg agctttttga cattctgatt aggaggtttc aagatgccgc aagaaaacaa 45241 tacattttac attacaacac cgatttatta tccgagcgga aaattacata tcggccatgc 45301 atatacgaca gtcgcaggag atgcaatggc acgttacaaa agattaaaag ggttcgatgt 45361 tcgctattta acgggaacgg acgagcatgg acaaaagatc cagcaaaaag ctgaacagga 45421 aaacattaca cctcaggagt atgtggatcg cgcagcggca gatattcaaa aactgtggaa 45481 gcagcttgaa atctcaaacg acgactttat ccgcacgaca gaaaaacggc ataaagttgt 45541 cattgaaaaa gtgtttcaaa agcttcttga taacggggac atctatcttg atgagtatga 45601 aggctggtac agcatccctg atgaaacgtt ctacacggaa actcagctcg ttgatattga 45661 gcggaatgaa aagggagagg tcatcggcgg aaaaagccct gacagcggtc acccagttga 45721 attgatcaaa gaggaatctt atttcttccg catggggaaa tacgcggatc gtcttctgaa 45781 atactatgaa gaaaacccga cattcattca gccagaatca cgcaaaaacg aaatgattaa 45841 taactttatc aaacctggac ttgaggattt ggcagtatca cgtaccactt ttgattgggg 45901 cgtgaaggtg ccggaaaatc caaagcatgt tgtatatgtt tggattgacg cactatttaa 45961 ctatttaacg gcactcggtt atgatacaga aaatgatgag ctttatcaaa aatattggcc 46021 tgccgatgtt catttagtcg gtaaggagat tgtacgattc catactattt actggccaat 46081 tatgctgatg gcgctggatc ttccgctgcc aaagcaagta ttcgcgcatg gctggctttt 46141 gatgaaagac ggaaaaatgt cgaaatcaaa aggaaacgtt gtagatccgg ttacattaat 46201 tgaacgctat ggtttagacg aacttcgcta ttacttgctt cgcgaagtgc cgttcggatc 46261 agacggtgtt ttcacgccgg aaggatttgt tgagcgaatc aactatgatt tagcgaatga 46321 tttaggaaat ctattgaatc gtactgttgc gatgattaat aagtattttg acggacaaat 46381 cggttcttac aaaggtgctg ttacggaatt tgaccatacg ctcacttctg ttgctgaaga 46441 aacagtgaaa gcttatgaga aagcaatgga aaatatggag ttctcggtag cactttcgac 46501 tttatggcag ctcatcagcc gcacaaacaa atacattgat gagacagctc catgggtgct 46561 tgcgaaagat ccggcaaaag aagaagaatt gcgatcagtt atgtatcatc tcgctgaatc 46621 attgcgtatt tcagcggtac tgcttcagcc attcttaaca aaaacacctg aaaaaatgtt 46681 cgagcagctg ggcattactg atgaatcttt aaaagcttgg gacagcatta cagctttcgg 46741 ccagctgaaa gatacaaaag tacaaaaagg cgagccattg ttccctcgtt tagaggcaga 46801 agaagaaatt gcttacatca aagggaaaat gcaaggttca gcaccagcga aagaagaaac 46861 aaaagaagaa gagcctcaag aggtcgatcg tttacctgaa attacgattg atcaatttat 46921 ggatgtagag cttcgcgtag ctgaggtcat tgaggcagag ccagtgaaaa aagcagaccg 46981 tttattgaag ctgcagcttg atcttggttt tgaaaagcgc caagtggtat ccggcattgc 47041 gaagcattat acgcctgaag agcttgttgg aaaaaaactc gtttgtgtaa caaatctaaa 47101 accggttaaa ctcagaggag agctttctca aggtatgatc cttgcaggag aagcagacgg 47161 cgttttaaag gtcgtatcta tcgatcagtc gttaccaaaa ggcacaagaa ttaaataatg 47221 ataaacaaaa ggtgtttcac gtgtaacaat tcgtcgaaca ccttttgtgt ttcgacaaga 47281 aaggagtttt tcacttatgt tgtttgacac tcacgcgcat ttaaatgcag aacaatatga 47341 tactgatctt gaagaggtta ttgaacgggc aaaagctgaa aaagttgaac gaattgtcgt 47401 agttggtttt gaccgtccga cgattacccg tgcgatggaa atgattgagg aatatgattt 47461 tatttatgca gccattggct ggcaccctgt tgacgctatt gacatgacag aggaagactt 47521 agcgtggatt aaagagcttt ctgctcatga gaaagtggta gcgatagggg aaatgggact 47581 ggattatcat tgggataaat cacctaaaga tattcaaaaa gaggtgttta gaaatcaaat 47641 cgccttagcg aaagaggtca atttgcctat tatcattcat aaccgtgatg caacggagga 47701 tgtcgtgacc attttgaaag aggaaggcgc agaagctgtg ggcggaatca tgcactgctt 47761 tacaggaagt gcggaagtgg caagagaatg catgaaaatg aatttttatt tatcatttgg 47821 gggaccggtg acatttaaaa atgcgaagaa accgaaggaa gtagtgaagg aaattcccaa 47881 tgaccggctg ctgattgaaa cggactgccc gtttctcaca ccgcaccctt tccgcgggaa 47941 aagaaatgag ccaagctatg tgaaatatgt ggcagaacaa atcgccgaat taaaagaaat 48001 gacctttgaa gagattgctt ccatcacgac tgaaaatgcg aaaagacttt tccgtataaa 48061 ctgacaaaaa acgctagcgg gttttgtaag agcttgtccc ttacagcgtt tttctataaa 48121 agttctacat gctttcttct cctcatagga taggtttgtc gacaagtctt tcttccgttt 48181 ctcagtgtat ttcaggataa tgaagaggac actgagcttt tgggagaaag agaagggagg 48241 gttgacagcc ttttagatac tctatataat ctctccgagg agaaggaggc gtttttcatc 48301 acacaaaaaa tgaaaaagct gttttccgta aagcttagca aaagcaaagt cattctggtt 48361 gctgcttgtt tgcttttggc aggaagcggg actgcgtacg cggctcatga gctgacgaaa 48421 caatcagtct cagtttctat caatggcaaa aagaaacata tacgcacaca tgcaaataca 48481 gtcggtgatc ttttggagac gcttgatata aagacaagag acgaagacaa gatcacacct 48541 gctaaacaga caaagataac agcagacatg gacgttgtgt atgaggctgc aaaacctgtg 48601 aagcttacaa taaacgggga agaaaagacg ttatggtcaa cagcaaaaac ggtcggtgca 48661 ttactggacg aacaagatgt tgatgtgaaa gaacaagatc aaattgatcc cgcaatagat 48721 acagatattt cgaaagacat gaagattaac atagagcccg catttcaggt tactgtgaat 48781 gatgcaggga aacaaaagaa gatctggacg acttcgacta cggtcgctga ctttttaaaa 48841 cagcaaaaga tgaacataaa agacgaagat aaaatcaagc ctgcgttaga tgcaaagctg 48901 acgaaaggaa aggctgatat tacaattact cgtatcgaaa aggtcaccga tgtagttgaa 48961 gagaagattg cgttcgatgt gaaaaagcaa gaagacgctt ctcttgaaaa agggaaagaa 49021 aaggtcgtcc aaaaaggaaa agaaggcaag ctaaaaaaac atttcgaagt cgttaaagaa 49081 aacggtaaag aagtgtccag agagcttgta aaagaagaaa cagctgaaca aagcaaagat 49141 aaagtgattg ctgtcggcac aaagcaaagc agtccaaaat ttgaaacggt cagtgcttca 49201 ggtgattcaa aaacagttgt gtcccgcagc aatgaatcaa caggcaaagt catgactgta 49261 tcatctacgg cttatacggc aagctgcagc ggttgttcag gacatacagc gacaggcgtc 49321 aatttaaaaa ataatccgaa tgccaaagtc atcgctgtgg atccaaatgt cattccgcta 49381 ggctccaaag tccacgtgga aggctatgga tatgccattg ctgcagatac cggttcagcg 49441 attaaaggga acaagataga cgtctttttc ccagagaaat catcggcgta ccgatgggga 49501 aataaaacag tcaaaattaa aatcttaaat tagtatatac ttatgtattc agagggtttt 49561 gcgccctctg tttttttcgt tataatagac aaagtgcatt ttctgcttat tagacgctcg 49621 atataagaaa aagtttcatg aatatacaaa agtttttatt ttgtcttgga ggaaataatg 49681 aaaattaaag agatcattgt ggtcgagggg cgtgacgata cggcccgcat caaattggct 49741 gttgatgcag acacaattga aacaaatggt tcagccatcg atgatcatgt gattgaccaa 49801 atccgtttgg cccagaagac gagaggcgtc attattttaa cggatccgga ctttccggga 49861 gagaagattc gcaaaaccat ctcagaggct gtacccggct gtaagcatgc atttttgcca 49921 aaacatcttg ccaaacctaa aaacaagcgg ggaattggtg tggagcatgc atcggttgaa 49981 agcattaggg catgtttaga aaatgtgcat gaggagatgg aagcgcagcc gagtgacatt 50041 tcagctgagg atttgattca tgccggacta ataggcgggc ctgcggccaa atgccgccgg 50101 gaacgactgg gtgatctgtt gaaaatcggc tatacaaatg gcaaacagct tcaaaaacgg 50161 ctgcaaatgt ttcaaattaa aaaaagtgat tttatgagtg cgctcgatac cgttatgcgg 50221 gaggaacaga atgaataaag atattgcgac accgattaga acgaaagaga tactgaagaa 50281 atacggtttt tcttttaaaa agagcttagg acagaatttc ttaattgata cgaacatttt 50341 aaacagaatt gttgatcacg cggaagtgac ggagaaaaca ggtgtcattg aaatcggccc 50401 gggaatcggg gctttaaccg aacagcttgc caagcgggcg aaaaaggtcg tggcatttga 50461 gattgaccag cgattattgc cgattctgaa ggatacactg tcaccttacg aaaatgtcac 50521 tgtcattcat caggacgtgt taaaggctga tgtcaaatca gtcattgaag aacaatttca 50581 agattgtgat gagatcatgg tagttgccaa ccttccttat tacgtaacaa caccgattat 50641 catgaaactg cttgaagaac atcttccgct gaaagggatt gtggttatgc tgcaaaaaga 50701 agtggctgag cgcatggcgg ctgatccttc atctaaggaa tacggctcgc tttcaatcgc 50761 ggtgcagttt tatacagaag ccaaaacggt gatgatcgtc ccgaaaaccg tatttgttcc 50821 tcagcctaat gtcgattccg cagtcattcg tctgattctc cgagacggcc cggcagtgga 50881 cgtggaaaac gaatcctttt tctttcagct catcaaggca agctttgcac agcgccgtaa 50941 aacgctgctc aataacttag ttaacaatct gcctgaagga aaagcacaaa aatcaacgat 51001 tgaacaagtg ctcgaagaaa caaatattga cggtaagcgc cgaggtgaat ccctgtctat 51061 tgaggaattc gcagcgctgt ctaacggatt gtataaagcc cttttctaaa agggcttttt 51121 gttttgcgca ccacatggac tgccgctaca taggctagag aaggaccttt cattcaatga 51181 taagaaaaaa cttggactca gcgaaaaaag gcgctttctc aaggctcttt ctttcatgat 51241 gaggcttagt ctatgtgtgg agtgaggaac gtgcaatttc aaatagggga tatggtagcc 51301 agaaaatcct atcagatgga tgttttgttt cgaattatag gaatagagca aacaagcaaa 51361 ggaaattcaa ttgccatttt gcatggagat gaagtcaggc tgattgctga ttcggatttt 51421 tctgatctgg tggcagtgaa aaaggatgag cagatgatgc ggaaaaagaa agatgagagc 51481 agaatgaatg agtcgctcga attgctccgc caagattata agctgctcag agaaaagcag 51541 gagtactatg cgacaagcca atatcagcat caggagcatt atttccatat gccgggcaaa 51601 gtgcttcatc tggatggtga cgaagcatat ttgaaaaaat gcctgaatgt ctataaaaaa 51661 attggagtgc cggtctatgg catccattgc catgaaaaga aaatgtctgc ttctattgaa 51721 gtattgctcg acaaatatcg acctgacatc ctggtgatca cagggcatga tgcgtactcg 51781 aagcaaaagg gcggtattga tgatttgaat gcgtacagac attctaagca ctttgttgaa 51841 acagttcaaa cagcccgaaa aaagatccct cacttagatc agcttgttat ttttgcgggg 51901 gcctgccaat cccattttga atcactcatc agagcgggtg cgaattttgc aagttcaccg 51961 tcaagagtca atattcatgc gcttgatccg gtatatatcg tcgcgaagat cagctttacg 52021 ccgtttatgg aacggattaa tgtatgggaa gtgctccgta atacgctgac aagagagaaa 52081 gggcttggag gtattgaaac aagaggagtt ctgagaattg gtatgcctta taagtccaat 52141 taacagttga aaacctgcat aggagagcta tgcgggtttt ttattttaca taatgataca 52201 taatttaccg aaacttgcgg aacataattg aggaatcata gaattttgtc aaaataattt 52261 tattgacaac gtcttattaa cgttgatata atttaaattt tatttgacaa aaatgggctc 52321 gtgttgtaca ataaatgtag tgaggtggat gcaatggcga agacgttgtc cgatattaaa 52381 agatcgcttg atgggaattt aggtaaaagg ctgacgttaa aagcaaacgg tggccgccga 52441 aaaacgattg agcgttcggg cattttagct gagacgtacc cttctgtttt tgtgatacaa 52501 ctagatcaag acgagaactc gtttgaaaga gtttcataca gttatgctga tattttgact 52561 gagactgttg agctgacatt taatgatgac gccgcaagct cagtggcatt ttaacgggca 52621 gtgaaccttt tgtttactgc tttttgtttt gccctttttt ggtttccaat aattttaacg 52681 aaagttccat ctgatttaac aaaagataaa acagtcacat attatcgtga cgtgcacgaa 52741 tggctatcac ttctaaaaaa ggagttgttt cgtttgggca gacgtcgtgg agttatgtca 52801 gatgagttta aatatgagct ggctaaagac cttggttttt atgacacagt aaaaaatgga 52861 ggctggggtg aaattcgggc ccgcgatgcc ggtaacatgg tgaagcgtgc tattgaaatc 52921 gccgaacagc aaatggctca gaatcagaat aaccgataag gatgtgaccc gggggacgtg 52981 ctgttccctg gtttttttat tttggatata aatacataat gggctgaata tggatatgtt 53041 catcctgtac ttcaaatgtg atacaatgtt catacttatg tttagatgga gaagtaggtg 53101 aaagctatgc gtattttaga aaaagcgcca gctaagatca atctgtcact tgacgtcacc 53161 cgaaaacgcc cggatggcta tcatgaagtc gaaatgatca tgacgacaat tgatttagct 53221 gatcgaattg aattgacgga gcttgcagag gatgaagtga gggtttcctc ccacaaccga 53281 tttgtgcctg atgaccaaag aaacttagct tatcaggctg ccaagctgat caaggacaga 53341 tacaacgtga aaaagggagt ttccatcatg attacgaagg taattccggt ggctgccggt 53401 cttgccggcg gaagcagtga tgcggcggcg acactcagag ggctgaacag actgtggaat 53461 ttaaatctgt ccgcggaaac gcttgctgag cttggagcgg aaattggctc tgacgtttca 53521 ttttgtgtct atggcggaac tgcattagca acagggcgcg gcgagaaaat taaacatatc 53581 agcacgcctc cgcactgctg ggtcatttta gcgaagccga caatcggtgt ttcaactgct 53641 gaagtgtaca gagcgctgaa actggatggt atagagcatc ccgatgtaca aggcatgatc 53701 gaggcgatag aagaaaagag ttttcagaag atgtgcagcc ggttaggcaa tgtgcttgaa 53761 tctgttacac tcgatatgca tcctgaagtt gcgatgatca aaaaccagat gaaacgcttt 53821 ggtgcagatg ccgtgttaat gagcgggagc ggcccgacag tgtttggact ggttcagtat 53881 gagtcgaagg tgcagagaat ttataacggg ttaagaggct tctgcgatca agtttatgcg 53941 gtgagaatga tcggcgaaca gaacgctctt gattaaatcc gtatgttaag ttatattgat 54001 cttaaaatat tcggattttg ggggtgagtt catgaagttt cgtcgcagcg gcagattggt 54061 ggacttaaca aattatttgt taacccatcc gcacgagtta ataccgctaa cctttttctc 54121 tgagcggtat gaatctgcaa aatcatcgat cagtgaagat ttaacaatta ttaaacaaac 54181 ctttgaacag caggggattg gtactttgct tactgttccc ggagctgccg gaggcgttaa 54241 atatattccg aaaatgaagc aggctgaagc tgaagagttt gtgcagacac ttggacagtc 54301 gctggcaaat cctgagcgta tccttccggg cggttatgta tatttaacgg atatcttagg 54361 aaagccatct gtactctcca aggtagggaa gctgtttgct tccgtgtttg cagagcgcga 54421 aattgatgtt gtcatgaccg ttgccacgaa aggcatccct cttgcgtacg cagctgcaag 54481 ctatttgaat gtgcctgttg tgatcgttcg taaagacaat aaggtaacag agggctccac 54541 agtcagcatt aattacgttt caggctcctc aaaccgcatt caaacaatgt cacttgcgaa 54601 aagaagcatg aaaacgggtt caaacgtact cattattgat gactttatga aagcaggcgg 54661 caccattaat ggtatgatta acctgttgga tgagtttaac gcaaatgtgg cgggaatcgg 54721 cgtcttagtt gaagccgaag gagtagatga acgtcttgtt gacgaatata tgtcacttct 54781 tactctttca accatcaaca tgaaagagaa gtccattgaa attcagaatg gcaattttct 54841 gcgttttttt aaagacaatc ttttaaagaa tggagagaca gaatcatgac aaaagcagtc 54901 cacacaaaac atgccccagc ggcaatcggg ccttattcac aagggattat cgtcaacaat 54961 atgttttaca gctcaggcca aatccctttg actccttcag gcgaaatggt gaatggcgat 55021 attaaggagc agactcatca agtattcagc aatttaaagg cggttctgga agaagcgggt 55081 gcttcttttg aaacagttgt aaaagcaact gtatttatcg cggatatgga acagtttgcg 55141 gaagtaaacg aagtgtacgg acaatatttt gacactcaca aaccggcgag atcttgtgtt 55201 gaagtcgcga gactcccgaa ggatgcgtta gtcgagatcg aagttattgc actggtgaaa 55261 taataagaaa agtgattctg ggagagccgg gatcactttt ttatttacct tatgcccgaa 55321 atgaaagctt tatgacctaa ttgtgtaact atatcctatt ttttcaaaaa atattttaaa 55381 aacgagcagg atttcagaaa aaatcgtgga attgatacac taatgctttt atatagggaa 55441 aaggtggtga actactgtgg aagttactga cgtaagatta cgccgcgtga ataccgatgg 55501 tcgcatgaga gcgattgcat ccatcacgct ggatcacgaa tttgttgtac atgatattcg 55561 tgtgattgat ggaaacaatg gtcttttcgt tgcgatgccg agtaaacgca cccctgatgg 55621 agagttccgc gatattactc atcctattaa ttcaagcacg cgaggaaaga ttcaagatgc 55681 cgtgttaaat gagtatcatc gtctgggtga cactgaagca ttagaattcg aagaagctgg 55741 agcttcttaa aaaataacca aaaagcaagg actgctgaaa gggctgacat aagccttttg 55801 ccggcggtcc ttttttaatt ctgatttttc aaacttagtt gcactcaata gaaaattctt 55861 gcacttcatg aagtctcctt gaaatcagaa gatatttagg atatattttt ctatggataa 55921 aagggatatt ggaggccaat aaatggataa gcggtttgca gttgttttag cggctggaca 55981 aggaacgaga atgaaatcga agctttataa agtccttcat ccagtttgcg gtaagcctat 56041 ggtagagcac gtcgtggacg aagccttaaa attatcttta tcaaagcttg tcacgattgt 56101 cggacatggt gcggaagaag tgaaaaagca gcttggtgat aaaagcgagt acgcgcttca 56161 agcaaaacag cttggcactg ctcatgctgt aaaacaggca cagccatttc ttgctgacga 56221 aaaaggcgtc acaattgtca tttgcggaga tacgccgctt ttgacagcag agacgatgga 56281 acagatgctg aaagaacata cacaaagaga agcgaaagct acgattttaa ctgcggttgc 56341 agaagatcca actggatacg gccgcattat tcgcagcgaa aacggagcgg ttcaaaaaat 56401 agttgagcat aaggacgcct ctgaagaaga acgtcttgta actgagatca acaccggtac 56461 gtattgtttt gacaatgaag cgctatttcg ggctattgat caggtgtcta atgataatgc 56521 acaaggcgag tattatttgc cggatgtcat agagattctt aaaaatgaag gcgaaactgt 56581 tgccgcttac cagactggta atttccaaga aacgctcgga gttaatgata gagttgctct 56641 ttctcaggca gaacaattta tgaaagagcg cattaataaa cggcatatgc aaaatggcgt 56701 gacgttgatt gacccgatga atacgtatat ttctcctgac gctgttatcg gaagcgatac 56761 tgtgatttac cctggaactg tgattaaagg tgaggtgcaa atcggagaag atacgattat 56821 tggccctcat acggagatta tgaatagtgc cattggcagc cgtacggtta ttaaacaatc 56881 ggtagtcaat cacagtaaag tggggaatga tgtaaacata ggaccttttg ctcacatcag 56941 acctgattct gtcatcggga atgaagtgaa gatcgggaat tttgtagaaa ttaaaaagac 57001 tcaattcgga gaccgaagca aggcatctca tctaagctat gtcggcgatg ctgaggtagg 57061 cactgatgta aacctgggct gcggttcaat tactgtcaat tatgatggaa agaataagta 57121 tttgacaaaa attgaagatg gcgcgtttat cggctgcaat tccaacttgg ttgcccctgt 57181 cacagtcgga gaaggcgctt atgtggcggc aggttcaact gttacggaag atgtacctgg 57241 aaaagcactt gctattgcca gagcgagaca agtaaataaa gacgattatg tgaaaaatat 57301 tcataaaaaa taatcctaaa ttcggaggtt tatccatgtc taatcaatac ggagataaga 57361 atttaaagat tttttctttg aattcgaatc cagagcttgc aaaagaaatc gcagatatag 57421 ttggagttca attagggaaa tgttctgtca caagatttag tgacggggaa gtccaaatta 57481 atatcgaaga aagtattcgc ggatgtgatt gttacatcat ccagtctaca agtgaccccg 57541 ttaacgagca tattatggaa ctgctgatta tggtagatgc gttaaaacgc gcttctgcaa 57601 aaacgattaa cattgttatt ccttattacg gttatgcgcg tcaagacaga aaagcaagat 57661 cccgtgagcc aatcacagct aaacttttcg ctaacctgct tgaaacagcc ggtgcgactc 57721 gtgtgattgc acttgacctg catgcgccgc aaattcaagg attctttgat ataccgattg 57781 accacttaat gggtgttccg attttaggag aatattttga aggcaaaaat cttgaagata 57841 tcgtcattgt ttcaccagac catggcggtg tgacacgtgc ccgcaaactg gctgaccgac 57901 taaaagcgcc aattgcgatt atcgataaac gccgtccgcg tccaaacgtg gcggaagtca 57961 tgaatattgt aggtaacatc gaagggaaga ctgctatcct catcgatgac attattgata 58021 ctgcaggtac gattacactt gctgctaatg cgctcgttga aaacggagcg aaagaagtat 58081 atgcatgctg tacacaccct gtactatcag gccctgcggt tgaacggatt aataattcaa 58141 caattaaaga gcttgttgtg acaaacagca tcaagcttcc tgaagaaaag aaaattgaac 58201 gctttaagca gctttcagtc ggaccgcttc tggccgaagc gattattcgc gttcatgagc 58261 agcaatcagt cagctatctg ttcagctaaa ccatttttcg aggtttaaat ccttatcgtt 58321 atgggtattg tttgtaatag gacaactaaa acgacaagag gatggtgctg aatatggcaa 58381 ctttaacggc aaaagaaaga acggacttta ctcgttcgtc tcttcggaat atccgtactt 58441 caggacatgt tccaggtatc atatatggga aggatacggg taacaaacct gtgtcattag 58501 acagtgtgga gctcatcaaa acgctgaggg acgaaggcaa aaatgcagtc attacgcttg 58561 aggtcagcgg agaaaaacac tcagtcatgg taacagacct gcagacggac ccgctgaaaa 58621 atgaaatcac tcatgctgat tttcaagtag ttaatatgag tgaggacatt gaagtggaag 58681 ttccgattca tctgaccgga gaagccattg gagtgaaaaa cggaggcgta ctgcagcagc 58741 cgttatatgc acttactgta aaggccaagc caaaagccat tccgcaaacg attgaggctg 58801 atatttcaag cctcgatgta aatgaagtac tgacgattgc ggatttgcct gctggcggtg 58861 actactcctt taatcatgaa tcagatgagg ttgtggcttc aatccttcct ccgcagcagc 58921 aggaagcagc tgaggtcgat gaagaggaat ctgccgatgc tcagcctgaa ggtgaaaacg 58981 aacaataata gcttaaggcg taaccctccc gcggttacgt cttttgtgct agaatgagaa 59041 gaattatagc ccgtttatga agacgggagt tatgtgacta agggaggatt cgccatgctt 59101 gtgattgccg gtctcggaaa cccggggaag aactatgaaa atacacggca taatgtcgga 59161 tttatggtga tagatcagct tgcaaaggaa tggaatatag agctgaatca aaataaattt 59221 aacggattat acggaaccgg atttgtttcc ggcaaaaagg ttctacttgt taaaccgctt 59281 acatatatga atttatcagg agaatgtttg cggcctttaa tggactacta tgatgtcgat 59341 aacgaagatt tgacagtcat ttacgacgac cttgaccttc cgactggcaa gatccgttta 59401 agaacgaaag gaagcgccgg agggcacaat ggcatcaaat cactgatcca gcatcttgga 59461 acgtccgagt ttgaccgtat ccgcatcgga atcggccggc ctgtaaacgg catgaaggtc 59521 gttgattatg tgttaggctc ctttaccaag gaggaggcac ctgagatcga agaagcggtt 59581 gataaatctg tgaaggcttg tgaggcttct ttgagtaaac cgtttttaga agtcatgaac 59641 gaatttaacg caaaggtata aaatgtaaca acaaagtcca tactacacca aaatgacttt 59701 ttcatcagga ggacccttgt atggctttgc attattattg tcgtcattgc ggagtgaaag 59761 taggcagtct cgaatcttca atggtatcga cagactcact tggatttcag cacttaacaa 59821 atgaggaaag aaacgatatg atttcttata aagaaaatgg agatgtccat gttttgacga 59881 tatgtgaaga ctgccaagag gcgcttgacc gaaatccgca ttaccacgaa tatcacacat 59941 ttattcaata aaaagctttg gtgtagacac tagaccaaag cgtttttctg ttctcgcagg 60001 aaacagagag gaggggccat atggacaaca ttcaaacctt tataaaagaa agcgatgact 60061 ttaaatccat catcaacggt ttacacgagg gcctgaagga acagctgctc gcgggtctgt 60121 cgggttccgc gcgttctgtt tttacttctg ctctggctaa tgaaacgaat aagcctatct 60181 ttctcatcac ccataactta tatcaagccc agaaagtaac agatgatctg acttcacttc 60241 tagaggatcg gtctgtcctt ttgtaccccg tcaatgaact catttcatca gaaatcgcag 60301 ttgcaagccc tgaattgcgg gcgcagcgat tagatgtcat taatagacta acgaatggag 60361 aagcgccaat tgtcgttgct ccggtagctg caatcagaag aatgctgccg cctgttgagg 60421 tgtggaaaag cagccagatg ctcattcaag taggccatga tattgaacct gaccagcttg 60481 cctcacggct ggtagaggta gggtatgagc ggtctgatat ggtttctgcg cccggggaat 60541 tcagtattcg cgggggaatc attgacattt atccgctgac ttcagagaat ccggtgagaa 60601 ttgaactttt tgacaccgag gtggattcaa tccgcagctt taattcagat gatcagcggt 60661 caattgagac ccttacctcg atcaatatcg gtcccgcgaa ggaattaatt atcagaccgg 60721 aagaaaaagc gcgggcgatg gagaaaatcg atagtggtct tgccgcgagc ttgaaaaaat 60781 taaaggctga caaacaaaaa gaaatacttc atgcgaatat ttctcacgat aaagaacgct 60841 tgtctgaagg ccagacagat caggagctcg tgaagtatct ctcatatttc tatgaaaagc 60901 ctgctagttt actagattat acacctgata atacacttct gattttggat gaagtcagtc 60961 ggattcatga gatggaagaa cagcttcaaa aagaagaagc ggagtttata acaaatcttc 61021 ttgaggaagg gaagattttg catgacattc gtttgtcatt cagcttccaa aaaatagtgg 61081 ctgagcaaaa acggcctctg ctgtactact ctttattttt gcggcatgta caccatacga 61141 gcccgcaaaa tatcgtcaat gtgtcaggcc ggcaaatgca gagtttccat ggccaaatga 61201 acgtgcttgc gggcgaaatg gagcgtttta aaaaatcaaa tttcactgtt gtgttcttag 61261 gagcaaacaa ggaacgtacg cagaaattgt catctgtttt ggctgattat gatatcgagg 61321 ccgccatgac agacagcaaa aaagcgcttg ttcagggaca ggtctatatc atggaaggcg 61381 agctccaatc gggatttgag ctgccgttaa tgaagcttgc cgttatcacg gaagaagaac 61441 tgttcaaaaa ccgtgtaaag aagaagccgc gaaaacagaa gcttaccaat gcagagcgca 61501 tcaaaagcta ttctgagctt caaattggag attatgtcgt tcatattaat cacgggatcg 61561 gaaaatacct ggggattgaa actcttgaaa tcaacggcat tcataaagac tatttaaata 61621 tacattatca gggcagtgac aagctttacg tccctgtaga acaaattgat caggtccaaa 61681 aatatgttgg ctccgaagga aaagagccaa agctgtataa attaggcgga agtgaatgga 61741 agcgggtcaa gaaaaaagta gagacatccg ttcaggatat tgctgatgac ttaattaagc 61801 tgtatgccga aagagaagcg agcaagggct atgcgttttc tcctgaccat gagatgcagc 61861 gtgaattcga atcggctttc ccttatcaag agactgagga tcagctccgt tctattcacg 61921 aaatcaaaaa agacatggaa agagaacgtc cgatggaccg cttgctgtgc ggagatgtgg 61981 gctacggtaa aacagaggtt gccatacgtg ccgcgtttaa ggcgatcggt gacggaaagc 62041 aggtagctct gctcgttccg acaaccattt tggcacagca gcactatgaa accataaaag 62101 agcgcttcca ggactatccg attaatatcg gccttctcag caggttcaga acgagaaaag 62161 aagcaaacga aacaatcaaa gggctgaaaa atggaacggt tgatatcgtc atcgggacgc 62221 atcggctgct atcaaaggat gtcgtgtata aagacttagg gctcctcatc attgatgaag 62281 agcagcgttt cggtgtaacc cataaagaaa agatcaagca aataaaagcc aatgttgatg 62341 tattaacgtt aacagcaacg ccgattccgc gtacgctgca tatgtctatg cttggcgtaa 62401 gggacctttc agtcatcgag actccgccgg aaaatcgctt ccccgtacag acgtatgttg 62461 tggaatataa cggcgctctt gtcagagagg cgattgaacg tgagcttgca cgcggaggcc 62521 aggtctattt cttgtacaac cgggtagagg acattgagcg gaaagcggat gaaatttcaa 62581 tgctagtccc tgacgcgaag gtagcatatg cgcatgggaa aatgacagaa aatgaattag 62641 aaaccgttat gctaagcttc cttgaaggag aatcagacgt tctcgtcagc acaaccatta 62701 tcgaaactgg cgtggacatc ccaaacgtca atacgctgat cgtatttgac gccgacaaga 62761 tgggactttc tcagctttac cagctgcggg ggcgtgtcgg ccgttctaac cgtgtggcgt 62821 atgcgtactt cacgtatcgc cgggataaag tgctgacaga agtggctgaa aaaaggctgc 62881 aggctattaa agaattcaca gagttaggtt ccggttttaa aatcgcaatg cgtgacttaa 62941 cgattcgcgg agccgggaat cttcttggtg cccagcagca tggcttcatc gattcggtcg 63001 gatttgacct ctattcacaa atgctgaagg aggccattga ggagcgtaaa ggagacacag 63061 cgaagacaga gcagtttgaa acagaaattg atgtcgagct tgatgcgtat attccggaaa 63121 cttatattca agacggcaaa cagaaaattg atatgtataa acgcttcagg tctgtggcga 63181 caatcgaaga gaagaatgag cttcaagatg aaatgatcga ccgctttgga aactatccaa 63241 aagaagtcga atacttgttt actgttgcag aaatgaaagt ctatgcgaga caggaacgtg 63301 tcgagctgat taagcaggat aaagatgctg tcagattgac gatttctgaa gaagcaagtg 63361 ctgaaattga cgggcagaag ctgtttgagc ttggcaatca atatggcaga caaatcggac 63421 tgggaatgga agggaaaaaa ctcaaaatct ccatacagac gaaaggccgt agtgctgatg 63481 aatggctcga caccgtgctg ggcatgctga agggcttaaa agatgtgaaa aagcaaacca 63541 tttcatcaac gtaaattttg ttactctctg gtgtatatta catttgatgt gacggatact 63601 aatttcaagc gaggcggaag gtacataaag taactgcttt aggtctttcc cacatgtata 63661 taccatcaaa tgaaagagag gcaccagaga tgaaagcaac cggtatcgta cgtcgtattg 63721 atgacttagg tcgggtcgtg attcctaaag aaattcgaag aactctgaga atcagggaag 63781 gcgatccgct tgagattttt gtagatcgtg acggagaagt gattttgaaa aagtactctc 63841 cgatcagtga gcttggagac tttgcaaagg agtatgcaga cgcgctttac gacagcctcg 63901 gccattcagt gctgatttgt gatcgtgatg tatatattgc cgtgtccggc agctccaaaa 63961 aagattactt aaacaagtca atcagcgaaa tgctggaaag aacaatggat cagcgcagct 64021 ccgtgcttga gagtgatgcg aaatcagtac agcttgtgaa tggaattgat gaggacatga 64081 attcttatac tgtaggccca attgtggcga acggtgatcc gataggtgct gtggtgatct 64141 tttcaaaaga tcagacaatg ggcgaagtag agcataaagc cgttgaaaca gcagctggat 64201 ttttggctcg tcaaatggaa cagtaggtct tattcctttc ttcgaaaata ggtatgtaaa 64261 gaacagctct ccttgggacg ctgttctttt tcatgcgtgc cgaaaaagga atccaagggt 64321 tgggatgtgg tataataacc tcgtttttat ttgtgccgcg gtaatacgtg aaccgtattg 64381 cccctgacgt tgggaaggag cttttggatg gacgattcaa taggcgttaa acggcattgg 64441 atttggcagg gggcttttgt tttaattctg gcaggcgtca tcacaaaaat tttaagcgct 64501 gtttacagag tcccgtttca aaacattgtc ggcgatgttg gattttatat atatcagcag 64561 gtatacccct ttcttggtat tgcggtcatg ctgtccacat caggatttcc agtcattatt 64621 tcaaagctga tgaatgatta tagtgaaaaa aatcatcaca ccatattaaa aatatcagcg 64681 ttgtttttgt ctttaatcgg tattttatta tttctttgtt tatatctggg tgctgttcct 64741 attgcactct ttatgggaga ttcgcatcta gccgtgttaa ttcaagtggc cgcatacgcg 64801 tttctgcttt tcccatttgt cgcgttgcta agaggcggtt ttcaggggcg gcacgaaatg 64861 ctcccttcag ccttatcaca gatgacagag cagtttctgc gtgttgcggt gctcttgggt 64921 ttatcatttt ggctcgtgaa aaagggagcc tcgctttata ctgcgggagc ggcagccgct 64981 tcaggctctc ttgccggaag tttggttgca ttgataatac tggggttttt ttggttcaaa 65041 acgaaaagag acaaccaaac ggataggcaa aacgaaaatg tcatcacaac aaaagaattg 65101 acgaaaaaac tgcttttata ttcggtcaca atttgtgtaa gcagtttgct gcttttgttt 65161 atccagcttg ttgatgcttt gaatttatat gcattgcttt cgggtggtga ggcaagcgaa 65221 gaagcaaaat gcctaaaggg gatctatgat cggggacaac ccttgttgca gctcggttca 65281 gtttttgccg taagcattgc gacgtcactc gttccgtata tttctatggc tgtaaaaaac 65341 aaagagctga agatcatgaa agaaaaaatc acgtcatctt tgaaactatg ccttgtgctc 65401 ggtacaggcg catcggctgg gttgatttgc attctaaagc cggtaaatat catgctgttt 65461 caaaatggag aagggacagg tgcgttacaa gtatttagct gctccatttt gtttgcatcc 65521 ttggcggtaa cggcagcggc agtcttacag ggagcgggat acacagtttt tcctgcgata 65581 gcggtgggcg cgggtgttgc ggtgaaatgg gtgttaaaca cacttttggt tccgcgctat 65641 gggattgaag gcgcatcgct tgcgacagcg gcttcctttg cggctgtcgc cggccttaac 65701 ttgtatcagc ttcggcaaaa ggaatggctc gataagctta gaggcgtttt gattccgatt 65761 attggatctg ctcttttgat gtcagctgtt ttgcttgcgt atacgcgtct ctggactttc 65821 ttgtttcctg caacaggaag aggagcggct gtgattgaga gtctttctgc tgttgccatt 65881 ggtggcgcgg tgtttattta ttgtatgatg agattgggaa tatttacaga tgaagagctg 65941 aacagtgtgc cattcggcag caagttaagc aaattcatga gaaggagaga acaaaatggc 66001 gggtaaaatt acagtcgtcg gacttggtgc cggagacatg gaccaattga caattggtat 66061 acacaagctg ctgacgaagg cagatacgct gtatgtcaga accaaggatc atcctttaat 66121 tgaggagctt gaaaaagaaa cgaagaacat ccgtttcttt gatgatatat atgagaaaca 66181 tgatcagttc gaggcggtat atgaagaaat tgcagatatc ctctttgaag cggcgcggcg 66241 tgaggacgtg gtttacgctg tgccgggaca cccttttgtc gcagaaaaaa cagttcagct 66301 gctgacggag cggcaggaaa aggaaaacgt tcaagtgaaa gtcgcggggg gacaaagttt 66361 ccttgatgcc acattcaatg tcttgcaaat tgacccgatt gaaggttttc aatttgtgga 66421 tgccggcaca ttgtccgcgg atgagcttga gctcagacat catctgatca tatgtcaggt 66481 ttacgaccaa atgacggctt ctgaagtcaa gctgacattg atggagaagc tgcctgatga 66541 ttatgaggtc gtcattgtga ctgcagcagg cagccgtggc gaggagatca ggacagtgcc 66601 attatttgag ctggaccgca atgtcgcttt gaacaactta acaagtgtgt atattccgcc 66661 gattaaagaa gagaagctgc tttatcacga attctccacg ttccgaagca tcatcagaga 66721 gcttcgcgga cctaatggat gtccgtggga taaaaagcag acgcatcagt cattaaagca 66781 gtacatgatt gaagaatgtt atgagcttct cgaagctatt gacgaagaag acacagacca 66841 tatgatcgaa gagcttggcg acgttttgct tcaggtcttg cttcacgcgc aaattggtga 66901 agatgaaggt tatttcacaa ttgatgatgt cataaaagga atcagtgaaa aaatggtccg 66961 aagacatccc catgtgttta aagatgttaa ggttcaggat gaaaacgatg ttttagccaa 67021 ttgggaagat ataaaaaagg ccgaaaaaaa tacatctgaa tcatcattac tagacagcgt 67081 accgaaaacc cttccagctc tttcgaaagc agctaaattg cagaaaaaag cagcgaaggt 67141 cggttttgac tgggaagacg tcagcgatat ttgggaaaag gtaagtgagg aaatgaagga 67201 attttcttct gaggtttctg aagctcctca cgaacacaat cttaaagctg agtttggcga 67261 cattttgttc gcgctggtga atgtagcccg cttctacaaa atagagccag aggaagcgct 67321 gaccatgact aatgacaaat tccggagacg gttctcgtac attgaggaaa cagcgaagga 67381 agagggagtc gagttggctg atatgtccct tgaggacatg gacaaactgt ggaatgaagc 67441 aaaagaaact gagaggagat catagatatg agattagata aatttttgaa agtatcacgg 67501 ctgatcaaac ggcgtacact agcgaaggaa gtagctgacc aaggacgaat ctctattaac 67561 ggaaaccaag ctaaagctag ctctgacgta aaaccgggag atgaactaac ggtccgcttc 67621 ggccaaaagc ttgtaacggt tcaagttaat gaattgaaag acacgacgaa aaaagaagaa 67681 gctgcaaaca tgtacacgat tctaaaagaa gaaaaactcg gcgaataggc ttgttctaaa 67741 aaaacccccc acctcataca atgcagtaat aatgctaaaa gtatcgagga tatgggggct 67801 gaatagatga attcatatta tgatcaaaaa ggttcttcgt ctgttccgga acagcatgat 67861 gtgacaatga aaggccggaa gcatttagat atttctgggg ttaagcatgt ggagagtttt 67921 gataacgaag aattcctgct ggaaacggtg atgggaatgc tctccgtcag aggccaaaac 67981 ctgcagatga aaaatcttga tgtggaaaaa gggattgttt cgattaaagg cagggtattt 68041 gatttagtgt acttagacga acaacaaggg gataaagcta aagggttttt tagcaagttg 68101 tttaaatgac gctgacgaca caattctata caatgctagc gatgtccggt atgggtctct 68161 ggcttggtgc ttcgcttgat acataccggc tctttgtcat tcgtgccaaa acagccagat 68221 ggctattatt tattcatgat attcttttct ggattatgca agggctgctt ttcttttatg 68281 tcttgcttca tgtaaatgag ggagaattca ggatttacat ctttttagcg gttctgctgg 68341 gcgttgcgac gtatcagagc ctttgcaaac gaatctatat aaaaatactg aaattcgtca 68401 tttaccttgt tgtttctgtt tatcaattct tcaaaaaact cattcagcac gtgttatttc 68461 gtcctattgt gtggacatgc ggagcgatca tctggctggc ggcattttta ttcaagaaaa 68521 catacagcct gataggtttt ctcctgctgt gtctatataa aatagtcatg gttctgtgtt 68581 ttccgatccg ttttatcgcg aaacaatgtt tgaaacttct tcctgtgaaa atgcgtctaa 68641 cttttagacg ttattttgaa aaaggtgcag gatttctcaa aaagaagaag aaactattga 68701 taaccataag aacgaccatc acacggtttt tgaagagatg aaaggaggac cgtctggttt 68761 gaatttttcc agggaacgaa cgataactga aatacaaaac gactataaag aacaagtaga 68821 acggcaaaat cagctgaaga aacgaagacg caaagggctg tacagacggt taactgtatt 68881 cggcgcccta gtattcctga cggcaattgt gctggcaagc tctgtatggt cccaaacatc 68941 ttcccttagt gcaaaagaag aaaagaaaga acagcttgaa aaagaactga aaagtttaaa 69001 gacaaaacaa acggatttaa aagaagaaat atccaaattg aaggatgagg attacgtcac 69061 agagcttgcc agaagggact tattcatgtc tggagacgga gaaattatct tcaatgtgga 69121 gaagaagagc aagtagcctt gttgacactt aaatttttat ttaggtataa ttaagcaaac 69181 gatcttttta taagcctaag gaggagcact ttttttatgt cgattgaagt tggcagcaag 69241 ttgcaaggga aaattacagg tattacaaat tttggagcat ttgttgaatt gcctggaggc 69301 tcaaccggtc tcgttcacat tagtgaggta gctgataatt atgtcaaaga cattaacgac 69361 cacttaaaag tcggcgacca agttgaagtg aaagtcatca acgttgaaaa agacgggaaa 69421 attggtttat ctattaaaaa agctaaagac cgtccgcaag ccagacctag aaatgatttc 69481 cgtccgaaag aatcttttga acagaaaatg aataagtttt taaaagacag cgaagatcgc 69541 ttgtcatctt taaaacgcaa tacggaatca aaacgtggag ggcgcggagc aagaagagga 69601 taacttgctg ctttctataa aataaatgaa gcatccgttc atcccgacgg atgctttttt 69661 attatcctca ttctctttaa gagtcagaaa attacaacat taaagtttct gttgacgaaa 69721 gagacaaacc tttgtattat ataacttgtg cttagaagca caaaacaata tggcggtgta 69781 gctcagctgg ctagagcgta cggttcatac ccgtgaggtc gggggttcga tcccctccgc 69841 cgctaccata tttgtttggc ccgttggtca agcggttaag acaccgccct ttcacggcgg 69901 taacacgggt tcgaatcccg tacgggtcat cctaacaaat cggtttctct tgcagaagcc 69961 gatttttttc atttttagac aacattccgg aaattctttt cataaacgaa tatcaaggca 70021 gaaaccgtcg aagatttctt tggtattgtt accttctttt gacaaaatcc tatctgtgct 70081 ttcgctataa tgacaggcaa cgaatataac aggtgggaga tgagaggaat ggaaaaagca 70141 gaaagaagag tgaacgggcc aatggcggga caagctttgg aaaaactcca atcgtttttt 70201 aacaggggca cgaagctggt gactcatcat ttgcattcac tgtttttcta taaaggattc 70261 atttatgttg tcatcggatt tttgcttgga cgggctttca tattatccga ggtgcttcct 70321 ttcgcacttc ctttctttgg agcgatgctt cttatcagaa gagacaaagc gttttatgcg 70381 gttttggctg tgcttgcagg tgcgctgacc atatctccaa agcactcatt gctcatactg 70441 gcggcattgc tggcattctt cgtattttct aaagtggctg ccttcattac cgacgatcgt 70501 gttaaagcgc tcccgattgt cgtgttcttc tccatggctg cagcaagagc cgggtttgtt 70561 tatgcccaaa atggcgtatt tacaacctat gattatgtaa tggctatcgt tgaggctgga 70621 ctatcgttta tcttaacact gattttcctt cagagccttc cgatttttac tgtgaaaaaa 70681 gtgaaacaat cattaaaaat agaggaaatc atttgcttta tgattcttat tgcctctgtt 70741 ttaacggggc tggctggctt gtcctaccaa gggatgcagg cagaacatat attggctcgt 70801 tatgttgtgt tgagtttttc ctttattggc ggagcaagca tcggctgtac ggttggggtt 70861 gtgaccggcc tgattcttgg cttggcgaat atcggaaacc tatatcaaat gagtctgctt 70921 gctttttccg gtttattggg cggtttgctg aaggaaggga aaaaagcggg tgcagcaatt 70981 ggtttgatcg ttggatcact tcttatatct ttatatggtg aaggctctgc cggtctgatg 71041 acaacgctct atgagtcatt aatcgcagtc tgcctgtttt tgctcacacc tcaatctatt 71101 acgaggaaag tggcgagata tattccggga actgtcgagc atcttcaaga gcaacagcaa 71161 tacgctagaa aaatccgtga tgtcactgct cagaaggtag accaattctc caatgtattt 71221 cacgcgctgt ctgaaagctt tgcaaccttt tatcaagcat cagacgaaca gacagatgac 71281 agcgaagttg atctgttctt aagcaaaatc acggagcatt cctgccagac gtgctacaag 71341 aaaaacaggt gctgggtaca gaactttgat aaaacatatg acttaatgaa acaagttatg 71401 cttgaaacag aggaaaaaga atatgcatca aaccgaaggc tgaaaaaaga gtttcaacag 71461 tattgttcta aatccaagca ggttgaagag ctgattgagg atgagctcgc acatcatcat 71521 gcccatttga cactcaagaa aaaagtccaa gacagcaggc gccttgttgc tgaacagctt 71581 ttaggcgttt ctgaggttat ggccgacttt tctcgggaaa taaaaagaga gcgagaacaa 71641 cactttctgc aggaagagca aatcatagaa gcgcttcagc atttcggaat tgagattcag 71701 catgtcgaga tctatagtct tgaacaagga aatatcgata ttgaaatgac cattccgttc 71761 agcggacatg gagaaagtga aaaaatcatt gctcctatgc tttctgacat tctggaggaa 71821 caaattcttg tgaaagccga acagcactct ccgcatccga atggatacag ccatgtcgcc 71881 tttggatcaa caaaatcata cagggtgtcc acgggagctg ctcacgctgc gaagggcggc 71941 ggccttgtct ccggtgacag ctacagcatg atggagcttg gagccagaaa atatgctgca 72001 gcaatcagtg acggaatggg caatggcgca agagcgcact ttgaaagcaa tgaaacgatc 72061 aagcttcttg aaaaaatcct tgaatcgggc attgatgaaa aaatagcaat taaaacgatc 72121 aacagcatac tgtctctaag gacaactgac gaaatatatt ccacgcttga cctatctatt 72181 atcgatcttc aagatgccag ctgtaaattt ttgaaggttg gatcgacgcc cagctttatc 72241 aaacggggtg accaggtcat gaaagttcaa gcgagcaatc tgccaatcgg tattattaat 72301 gaattcgatg tggaggttgt gagtgaacag ctgaaagcgg gtgacctctt aattatgatg 72361 agtgatggca tttttgaggg gcctaagcat gtggaaaatc acgacttatg gatgaagcgt 72421 aaaatgaaag ggttgaaaac aaatgacccg caggagattg ccgatttgct tatggaagaa 72481 gtcatccgca caagatccgg ccaaattgag gacgatatga ctgttgttgt cgtccggatt 72541 gatcacaata caccgaagtg ggcatccatt cctgttccgg caatctttca aaacaaacaa 72601 gaaatttcat aacgcttccg tataaatcaa atttcttctg gcgaagatgg gaatatatga 72661 atctgagaat cctcgtattc tccaggagga atgaatgtga acaacggaca tttaaatcaa 72721 attttgctga taacggatgg ctgctcaaac catggggaag acccgcttgc aatggctgct 72781 tttgctaaag agcaggggat tacggtaaat gtcattggta taatggaaga aaatcaaatt 72841 gaccctgagg caatgaagga agtcgaaggg attgcacttg ccggaggagg cgtgcaccaa 72901 gtcgtttatg catctcagct ttcacaaact gttcaaatgg taacaaagaa agcgatgacg 72961 caaaccttac aaggtgtagt caatcaagaa ctgaaacaga ttctcggaaa gaatgtggaa 73021 atggaagagc tttctccgga aaaacgcggc gaagtcatgg aagtggtaga cgagcttgga 73081 gaaacggtgc atcttcaggt tttggttctt gttgatacaa gtgcaagtat ggcgccaaag 73141 cttccaacag taaaagaggc gctgattgat ttgtctgtaa gcctcaattc ccgaattggg 73201 aataacgaat ttgcgatgtg tatatttccc gggaaaaaac aagaggtcga gcttgtgctg 73261 aactggacac cgaagctgca atctctttcc acactctttg caaagctttc gacaggcggc 73321 atcacgccga caggtccggc gattcgtgaa gcgacactgc agtttgaaaa aatacgctca 73381 agaaggggca tgctggcaga tgatgaacga cgctttgacg agtttggcat gtagcctcaa 73441 gccgggtacg acaatcaaag gcaagtggaa tggaaacact tatacattgc gtaaacagct 73501 tggtaaaggg gccaatggaa ttgtgtattt ggcagaaaca tcagatggac atgttgcctt 73561 aaaggtgagt gatgacagcc tgtctattac ttctgaagtg aatgtcttga aatctttctc 73621 aaaggcccag tccgttacga tggggccttc tttttttgat acggatgatg cctatattcc 73681 cagtgccaat acgaaagttt cattttatgc aatggaatac ataaaagggc cgctgctttt 73741 gaagtatgtc agtgataaag gagcagagtg gataccggta ttaatgattc agctgttatc 73801 cagcttatcg gtgcttcacc agcaaggatg gatattcggc gatcttaaac ctgataatct 73861 gatcgtaact ggtccgcccg caaggatccg ctgcattgat gtgggcggca cgacaaagga 73921 aggccgggcg ataaaagagt atacggagtt ttatgacaga ggctattggg ggtatggaac 73981 aagaaaggca gagccatcct atgatctgtt cgcagttgcc atgattatga tcaacagtgt 74041 gcataaaaaa gaatttaaga aaacgaacca gcccaaagaa cagcttaggt ctctcatcga 74101 aggaaacccg ctgcttcaaa agtataaaaa agcgcttttt tcagccttga acggagatta 74161 tcaatccgca gatgaaatga aaaaggatat gctagacgcg gggcaaaaag cagcacaaag 74221 aaaacagcct ataaaagcat caccgcagcc tgccacacga caaagacagc aaaaaccgcg 74281 ccaaggaaaa ataacgaaga cgcgatatac cccaaaacag aaaccggcta agtcgggggg 74341 gttatttgaa acaacgctta tcgtgatcag tgttttagcg ctttatttcg cctatattat 74401 ctttttctta atctgaatgg tgcaaactgc agagcctatg cttcttcttt gcttggaggg 74461 gttgaaagtg ttaggatatg aatatcttta aaatacctgc tcattgtgag gaggacattg 74521 tgaaaagtgt caaagatttt ttaaacaaac acaatcttac gttaaaaggg gcgacaatca 74581 ttgtaggcgt ttccggcggt ccggactcaa tggctcttct tcacgcgttg catacgttat 74641 gcggccgttc agcgaatgtt attgcagctc acgttgacca tcggttcaga ggtgcggaat 74701 ccgaggagga catgcgtttt gtccaagctt attgtaaagc tgaacagctc gtgtgcgaaa 74761 cggctcaaat caatgtaacc gcatatgcac aggaaaaagg actcaataag caggctgcag 74821 cacgcgattg ccgctaccag ttttttgagg aaatcatgtc gaagcaccaa gcggactatc 74881 tggctcttgc gcatcatggt gatgaccagg ttgaaacaat gcttatgaaa ctggctaagg 74941 gtacgcttgg aacgggactt gcgggaatgc agccggttag acgttttggg acagggcgga 75001 tcatcaggcc gttcttaacc attacaaagg aagagatcct tcactattgc catgaaaacg 75061 gcttgagcta ccggacggat gaaagcaacg ccaaagatga ctacacaaga aacagattca 75121 gaaaaacagt gctcccgttt ttgaagcagg aatctccgga tgtgcataaa aggtttcaga 75181 aagtgagtga agcactgacg gaagatgagc aattcttaca gtcattaacg aaagatgaaa 75241 tgaataaagt aatcacaagc cagtctaata catcagttga aatcaattcc tctcaattgc 75301 ttgccctccc gatgccttta caaagaagag gagttcaact aatattaaac tatctttatg 75361 aaaacgttcc atcatccttt tcagcccatc acattcagca gtttctcgat tgggcggaaa 75421 atggcggtcc ttcaggagta ctggactttc cgaaagggct gaaggtggtc aaatcatatc 75481 agacatgttt gtttacattt gaacaatggc agtgcaaaaa tgttcccttt gaataccaaa 75541 ttagcggagc tgctgatgaa acggcagtgc tccctaatgg atatctgata gaggcaaggc 75601 attatgcgga ctcgcctgaa gaacatggga atgctgtttt tatcacaagt gaaaaaaagg 75661 tgcgatttcc cttaacaatc cggacgagaa aagctggaga ccggatcaaa ctaaaaggga 75721 tgaacggctc aaaaaaggta aaggatatat ttattgataa gaaattgcct ctccaagaaa 75781 gagacaactg gccgattgtg acggacgcaa gcggtgaaat tatctggata cctggcttga 75841 aaaaatcaat ttttgaagat cttgtgattc caaacagcga ccgcattgta ttacaatata 75901 gacagcatga aaagtgtagg gggcaagcaa aatcatgatg aaacatgata tcgagaaagt 75961 actgatctca gaggaagaga tacaaaagaa agtaaaagag ttaggtgcag aattaacgag 76021 cgagtatcaa gatacatttc cgttggcaat cggtgtgtta aaaggagcac ttccttttat 76081 ggcggatctt atcaagcata ttgatacata tttggaaatg gatttcatgg atgtatcaag 76141 ctacggaaat tctacggttt cttctggaga agtaaaaatc attaaagatt tggatacatc 76201 tgtagagggc cgggacatct taattattga agatatcatc gacagtgggt taaccttaag 76261 ttatctcgta gagctcttcc gataccgtaa agcaaaatca attaagattg ttaccctttt 76321 ggataaaccg agcggaagaa aagcggacat caaagcagac tttgtcggtt ttgaagttcc 76381 tgacgcgttt gtagtgggtt acggacttga ttatgctgag cgctatcgca atctgcctta 76441 tatcggagtg ttaaaaccgg cagtttatga aagctgatcg gcagcctgct tccgagatgg 76501 ttattgtttg tattggaatg attttctatg gtactattga acatagttgt gcttactgtg 76561 ggaggaggta aggaatgaat cgggtcttcc gtaataccat tttttattta cttattttat 76621 tagtagtaat cggggttgtg agctacttcc agacctcaaa tccgaaaaca gaaaatatgt 76681 cgtacagtac gttcatcaaa aacctggatg acgggaaagt tgatagcgta tcggttcagc 76741 ctgtcagagg tgtttatgag gtaaaagggc agctgaaaaa ctacgacaaa gatcaatact 76801 ttttgactca tgttcctgaa ggaaagggag cagaccagat atttaacgct ttgaaaaaga 76861 cagacgtaaa ggttgagccc gcgcaagaaa caagcggatg ggtgacgttc ctgacgacca 76921 tcatcccatt tgtcattatc tttattctgt ttttcttcct gctcaatcag gctcaaggcg 76981 gcggcagccg tgtcatgaac tttggcaaga gtaaagcgaa gctgtataca gaggaaaaga 77041 aacgcgtcaa atttaaagac gttgcagggg ctgacgaaga aaagcaagaa cttgttgaag 77101 ttgttgagtt tctgaaagat ccccgcaagt ttgccgagct cggcgccaga ataccgaaag 77161 gcgtgctttt agtcggacct ccgggtaccg gtaaaacatt gcttgccaag gcttgtgcag 77221 gagaagccgg cgtacctttc ttcagcatca gcggatctga tttcgttgaa atgtttgtag 77281 gggtcggtgc ttcccgtgtg cgtgacttgt ttgaaaatgc gaaaaagaat gcgccttgtt 77341 tgatcttcat tgatgaaatt gacgcagtcg gacgccagcg tggcgctggt ctcggcggtg 77401 gacacgatga acgtgaacag acgctaaacc aattgcttgt tgaaatggac ggattcagcg 77461 ctaatgaagg aattatcatc attgctgcga cgaaccgtgc ggacatcttg gacccagcct 77521 tacttcgtcc gggacgtttt gaccgtcaaa tcacagtgga ccgcccagat gtcattggcc 77581 gtgaagctgt attgaaagtc catgcgagaa acaaaccgct ggatgaaacg gttaacctaa 77641 aatcaattgc catgagaaca ccaggcttct caggcgctga cttagaaaac ctcttgaatg 77701 aagctgcgct tgtagcggct cgtcaaaaca agaaaaaaat cgatgcgcgt gatattgacg 77761 aagcgacgga ccgtgtaatt gccggacccg ctaagaagag ccgcgttatc tccaagaaag 77821 aacgcaatat cgtggcttat cacgaaggcg gacacaccgt tatcggtctc gttttagatg 77881 aggcagatat ggttcataaa gtaacgattg ttcctcgggg ccaggctggc ggttatgctg 77941 ttatgctgcc aagagaagac cgttatttcc aaacaaagcc ggagctgctt gataaaattg 78001 tcggcctctt gggcggacgt gttgctgaag agattatctt cggtgaagtc agcacagggg 78061 cgcacaatga cttccagcgt gcgacgaata ttgcaagacg aatggttaca gaattcggta 78121 tgtcagaaaa actgggaccg ttgcaatttg gacagtctca gggcggtcag gtattcttag 78181 gccgtgattt caacaacgaa cagaactaca gtgatcaaat cgcttacgaa attgatcagg 78241 aaattcagcg catcatcaaa gaatgttatg agcgtgcgaa acaaatcctg actgaaaatc 78301 gtgacaagct tgaattgatt gcccaaacgc ttctgaaagt tgaaacgctt gacgctgaac 78361 aaatcaaaca ccttatcgat catggaacat tacctgagcg taatttctca gatgatgaaa 78421 agaacgatga tgtgaaagta aacattctga caaaaacaga agaaaagaaa gacgatacga 78481 aagagtaatt cgctttcttt ctaaaaaaac tgccggctga cgctggcagt ttttttatgt 78541 aaatgattgg ctcagctgcg gcttttacaa tcatccaatt ctggtatcga tttgtttaca 78601 aatgagccgc tgatcgtgta tggtattgta gaatgtttgt aaaaagtaaa gtagagaaac 78661 tattcaaaag tggtgataga ggttgttact ggttatcgat gtggggaaca ccaatactgt 78721 acttggtgta tatcatgatg gaaaattaga atatcactgg cgtatagaaa caagcaggca 78781 taaaacagaa gatgagtttg ggatgatttt gcgctcctta tttgatcact ccgggcttat 78841 gtttgaacag atagatggca ttattatttc gtcagtagtg ccgccaatca tgtttgcgtt 78901 agaaagaatg tgcacaaaat actttcatat cgagcctcaa attgttggtc caggtatgaa 78961 aaccggttta aatataaaat atgacaatcc gaaagaagta ggggcagaca gaatcgtaaa 79021 tgctgtcgct gcgatacact tgtacggcaa tccattaatt gttgtcgatt tcggaaccgc 79081 cacaacgtac tgctatattg atgaaaacaa acaatacatg ggcggggcga ttgcccctgg 79141 gattacaatt tcgacagagg cgctttactc gcgtgcagca aagcttcctc gtatcgaaat 79201 cacccggccc gacaatatta tcggaaaaaa cactgttagc gcgatgcaat ctggaatttt 79261 atttggctat gtcggccaag tggaaggaat cgttaagcga atgaaatggc aggcaaaaca 79321 ggaaccaaag gtcattgcga caggaggcct ggcgccgctc attgcgaacg aatcagattg 79381 tatagacatc gttgatccat tcttaaccct aaaagggctg gaattgattt atgaaagaaa 79441 ccgcgtagga agtgtatagg aggtttagta atggattatt tagtaaaagc acttgcgtat 79501 gacggaaaag ttcgggctta tgcagcgaga acgactgata tggtaaatga ggggcagaga 79561 cgccatggta cgtggccgac agcatccgct gcactaggcc gtacaatgac agcttcactt 79621 atgctcggcg ctatgctgaa gggcgatgat aagctgaccg tgaaaatcga gggcggaggt 79681 ccgatcggag ctattgtagc tgatgccaat gccaaaggag aagtcagagc ctatgtctct 79741 aacccgcaag ttcattttga tttaaatgaa caaggtaagc ttgatgtcag acgtgcggtt 79801 ggaacaaacg gaacgttaag tgtcgtaaaa gatttaggtt tgcgcgagtt cttcacagga 79861 caagtagaaa tcgtttcagg agaattagga gatgatttta cttactatct tgtgtcatct 79921 gagcaggttc cttcatcagt gggcgtaggt gtgctcgtaa atcctgacaa taccattctt 79981 gcggcagggg gctttattat tcagctgatg ccgggaacag atgatgaaac aatcacaaaa 80041 attgaacagc gtctatctca agtagagccg atttctaagc tcatccaaaa agggctgaca 80101 ccagaagaaa ttttagaaga agtcctaggc gagaaacctg agattttgga aacgatgcct 80161 gtcagattcc attgcccttg ttcaaaagaa cggttcgaaa cagccatttt aggactaggc 80221 aaaaaagaaa ttcaagatat gatagaagaa gatggacaag ccgaagcagt atgccatttt 80281 tgtaatgaaa agtacttatt tacaaaagaa gagctggaag ggcttcgtga ccaaactacc 80341 cgctaagctc tttagcgggt ttttaatttg agaaaagggg ctgaaagcag gtttgaaatc 80401 aagaacaatc tggaccatta ttttaggggc gctgttggtt tgctgtattg ctgttgcata 80461 tacgctgacg aaatcccaag ccggcgcatc gtcatccggt gagtctattg cgactatcgg 80521 aggcaagagt gtgacaagag aagaatggct gaaagaaatg gaagatcagt atggtaagtc 80581 aacgcttgaa gatatgatca atgtccgagt tgttgagcag ctggctaaaa agaacaaact 80641 taaaatatcc aaaagcgaag ttgatcgtga gtttttgctg attaaagcgg tcaataattc 80701 cttttacgaa gatgaacata cgacggagaa agagtggaaa gaccaaattc gttataatat 80761 cctccttgag gatttgttaa caagggatat cgatatctca aacaaagaat tggaatcatt 80821 ctataataaa aataaggaac tatatcagtt tgatgattcg tatcgaattc ggcacattgt 80881 tgtaaaagat gaagaagaag caagagaagt cctgaaagaa ctgaaaggcg gatcaagctt 80941 tgaagctgtc gctgccgaaa gatctacaga cagatataca tcaccatacg gcggagattt 81001 aggttttgtc acagaggcat cagacaacat tccatcagca tacattgaag aggcgaaaac 81061 actcaaagag gatgaatggt ctcaggaacc aataaaggtc agcaacggat atgccattat 81121 ccagctgaaa gaaaaactaa aggcaagaac gttctcattt gatgaagtaa aggaccagat 81181 cagacggcaa atcgcaatgg atcagctagg cgataaagcg acagttaaga cactttggaa 81241 agaagccgat gtatcttggt tttatgggga aaaaagtact aagtgattga caaaaaattt 81301 tgaaattgat agattatata cataatacca atacaaatag tcggaaattg aggtgtcgag 81361 aatggtacgt gtagcaaact ccattactga attaattggg aatacgccaa tcgttaaatt 81421 aaatcgcctt gcagatgaaa acagtgcgga tgtatatcta aaacttgaat acatgaaccc 81481 tggaagcagt gtaaaagacc gtatcggttt agctatgatt gaagcggctg aaaaagaagg 81541 aaaattaaaa gccggtaata caatcattga accgacaagc ggaaatactg gaatcgggct 81601 tgcaatggtt gctgctgcta aaggattaaa agccattttg gttatgcctg atacaatgag 81661 catggagcgc cgcaaccttc ttcgcgcata tggtgctgag cttgtgctga ctcctggtgc 81721 ggaaggcatg aaaggtgcta ttaagaaagc tgaagagctt gctgaaaagc acggatactt 81781 tgtgccgcag cagtttaaca acccttctaa ccccgaaatt caccgccaaa caacgggtaa 81841 agaaatcgtt gagcaattcg gtgatgatca gcttgacgca tttgtagccg gaatcggaac 81901 gggcggaacg attacgggag cgggcgaagt gctgaaggaa gcataccctt ccatcaagat 81961 ttatgctgtt gaaccgtcag attccccagt gctttcagga ggaaaaccag gcccccacaa 82021 aattcaggga atcggagcag gattcgtgcc ggacatctta aacactgaag tatatgatga 82081 aatcttccct gtgaagaatg aagaagcatt cgaatatgcc cgcagagctg cacgtgaaga 82141 aggaattctc ggaggcatct catcaggtgc ggcaatttat gctgctcttc aagtagcaaa 82201 aaaactcgga aaaggcaaaa aagtattggc catcattcca agtaacggcg aacgttatct 82261 aagcacgccg ctgtaccaat tcgattaaaa aaagccaaaa ctcccggttc gccgggagtt 82321 tttttatatt tcgtgcatca aatatgccat gtctgcgacg aatgttattc ttggaagaga 82381 aattcacttt tttcactaac aacattgctt tacaattaaa aacaagtaaa aaagaaaata 82441 gaggaatgat acaaatggca caacgcagac cggcaggcaa aaaaatacct tttcaaaaag 82501 actcattctt acaacaattt gagaaacttg cgcaatcccg gaaacatcat gtacttctcg 82561 aaagtgcaag aggcggcaga tatagtatag ccggtcttga tccaattgcg actgtgaaag 82621 gaaaagacgg aataactaca attaagcatg gtgatgagat gctgtttaaa gaaggtgatc 82681 cattacgggc cttccacagc tggtttaaaa cactggaaac agaaacgaat catgagttcc 82741 ctgactttca aggcggggca atcgggtttc tcagctatga ttacgcacgg tacattgaaa 82801 attttaaaat gctctcatta gatgatttag aaacaccaga tatttatttt cttgtttttg 82861 atgatatagc agtttatgac catcaagaag agtctctatg gctgattact catgttaatg 82921 gttctgatca ggaaacagcg gatgtgaagc tatctgagtt agagcagatg tggttgactg 82981 agcttcccgc tgtcacttcg cgagagatga agcctgaaac agctggttct ttcgcggcgc 83041 catttaccga ggatgggttc tcacaagctg tagagaaaat caaacaatac attgccagcg 83101 gagatgtgtt tcaagtcaat ctatcaataa ggcagtcaca gtcactgtct gtccacccat 83161 atcaaattta caaaaccttg agagaagtaa atccttctcc ttatatggcg tatttagaaa 83221 cacctgattt ccaaatcatt tgcggatcgc ctgaactgct tgtcagcaaa aagggcaagc 83281 tattagagac gagaccgatt gcgggcaccc gttccagagg gaaaacaaat gaagaagacg 83341 aggcgcttgc aaacgaattg atacacaatg aaaaagaacg cgcggaacat gtcatgctgg 83401 ttgatcttga gcgaaatgat ctgggaagag tatcacgtta cgggtctgtg cgcgtaaatg 83461 aattcatggc aattgaaaaa tactcgcatg tgatgcacat tgtgtctaat gtccaaggtg 83521 aactgcagga tgggtatgat gctgtagata ttattcatgc tgtgtttccc ggaggaacca 83581 ttactggtgc accgaaagta agaacgatgg aaattataga agaacttgag ccgacacgcc 83641 gagggcttta tactggatct ataggatggt ttggatataa tcacgatctg cagtttaata 83701 tcgtcattcg aaccatttat gcaaccggag ggcaggcatt tatgcagtcc ggtgcaggag 83761 ttgtgattga ttctgttccg aagcacgaat acaaggaatc attcaaaaaa gcttttgcga 83821 tgcaaagagc attagagctg agcgaagaag agacaaaaat tagatgaggt gagcggagaa 83881 atgattttaa tgattgataa ctacgattca ttcacgtaca acttggtaca gtatttgggc 83941 gagcttgggg aagagctggt tgtgaaacgc aatgacagca tcacaatcga tgaaattgaa 84001 gaactgtctc cggactttct gatgatatct cccggaccgt gcagccctga tgaggcggga 84061 atcagcctcg aagcaattaa acatttcgca gggaaaattc ctattttcgg tgtatgtctc 84121 ggacatcagt ccatcgcaca agtgttcggt ggtgatgttg ttagggcaga acggcttatg 84181 cacgggaaaa cctcggatat cgagcatgac ggcaaaacca tttttgaagg gttgaaaaat 84241 ccccttgttg cgacgcgata ccactcgctg atcgtaaaac ctgagacgct gccaagctgt 84301 tttacagtaa cagcacaaac gaaagaagga gaaatcatgg ctattcgcca caatgacctc 84361 ccgatagagg gtgtgcaatt tcacccagag tctattatga cctcctttgg gaaagaaatg 84421 ctcagaaatt ttattgagac atatcgcaag gaagttattg cgtgatgata tatgtgaacg 84481 gccggtatat ggaggagaaa gatgcagttc tttctccttt tgaccatggg tttttatatg 84541 ggatcggtgt tttcgaaacc ttcaggctct acgaaggctg cccgtttttg cttgattggc 84601 atatagagag gcttgaacgc gcgcttaagg atctgcaaat cgaatatact gtttcaaagc 84661 atgagatcct tgagatgctg gacaagctgc ttaagctaaa tgatatcaag gatggcaatg 84721 cccgcgtcag actgaacata tcagcgggaa tcagcgataa aggctttgtc gcccagacgt 84781 acgataagcc caccgtttta tgctttgtga atcagctgaa accagaaagt cttcctttgc 84841 aaaaagaagg aaaggtttta tcgatacgga gaaacactcc agagggatcg ttccggttaa 84901 aatctcatca ttatctaaat aatatgtatg cgaaacggga aattggaaat gatccgcgtg 84961 tcgagggaat tttcttaacg gaggatggag ctgttgcaga gggtatcata tctaatgtct 85021 tctggagaaa aggtcgctgt atctatacgc catcgcttga taccggtatt ctggacggcg 85081 tcacgagacg ttttatcata gaaaatgcaa aggatatcgg cctggagctc aaaacgggcc 85141 gatatgagct agaagctctc ttgacagctg acgaagcgtg gatgacgaac tcggttcttg 85201 aaatcatccc gtttactaaa atagaagaag taaactatgg aagccaaagc ggagaagcaa 85261 cctccgctct tcaattgtta tacaaaaaag aaataaagaa catgattcat gaaaagggag 85321 gaagagcatg gcgcagcaca caatagatca aacacaagta atccacacta agcccagcgc 85381 tttatcatat aaagagaaga cgctggtgat gggaatttta aacgtaacgc ctgactcttt 85441 ctcggacggc ggaaaatatg acagcttgga caaggcgctg ctgcacgcga aagagatgat 85501 cgatgatggt gcccatatca ttgatattgg aggggaatcg acaaggcctg gcgctgagtg 85561 cgtatctgag gatgaggaga tgtccagagt cattccggtg attgagcgga ttacgaaaga 85621 gcttggtgtt cctatttctg tagacacgta caaggcttct gtcgcagatg aagcagtgaa 85681 agccggtgca tccattatca atgatatttg gggagccaaa catgatccga agatggcttc 85741 cgttgcagct gaacataatg ttccaattgt actcatgcat aaccgccctg aaagaaacta 85801 caatgactta ttgccggata tgctgtcgga cttaatggag agtgtaaaaa ttgctgttga 85861 ggccggagta gacgagaaga acattattct tgatcctggt atcggtttcg cgaaaaccta 85921 tcacgataac ttggcagtga tgaacaaact agagattttc agcggattgg gatatccggt 85981 tcttctggca acctcccgaa aaagattcat cggacgtgtt ctggatcttc cgcctgagga 86041 gcgggctgag ggcacaggcg cgactgtgtg tctcggcatt caaaaaggct gtgacattgt 86101 cagggtccat gatgtaaagc aaattgccag aatggcgaaa atgatggacg cgatgctgaa 86161 taagggaggg gtgcaccatg gataaagttt atgtagaagg tatggagttt tacggatatc 86221 acggtgtgtt cacagaagaa aacaaacttg gccagcggtt taaagtcgat ttaaccgctg 86281 agctggattt aagcaaagct ggacagacag acgaccttga gcaaacgatc aactatgctg 86341 agctctatca cgtatgtaaa gatatcgtgg aaggggagcc tgtgaaattg gtggaaacgc 86401 tggcggaacg tattgctggc actgttctcg gaaaatttca gcctgttcag caatgtacgg 86461 tgaaagtgat taagccagac ccgccaattc ccggacacta taaatcagta gcaattgaaa 86521 ttacgagaaa aaagtcatga acaacatagc ttatattgca cttggatcta atattggaga 86581 tagagaaacg tatttaaggc aagcagtggc tttactgcat cagcatgctg cggtgacagt 86641 cactaaagtg tcgtctattt acgaaactga cccggtcgga tacgaagatc aagctcaatt 86701 tttgaatatg gctgttgaaa tcaagacatc attgaaccct tttgaactcc ttgaactgac 86761 gcagcagata gaaaatgaat taggcagaac aagggaagta agatgggggc cgcggacggc 86821 agaccttgac attttgttat ttaatcgtga aaatattgaa acagagcaac taattgttcc 86881 gcatccgaga atgtatgagc gtttgtttgt ccttgcgccg cttgcggaaa tttgccagca 86941 ggttgaaaaa gaggctacaa gcgccgaaac agaccaagaa ggtgtaagag tatggaagca 87001 gaaatctggg gtagacgaat tcgtgcattc agaaagctga aaggttatac tcaagaagga 87061 tttgcaaaag cattaggtat atcagtttct attctcggcg aaattgaacg cggaaaccga 87121 ttgccgtctg ctgccatcat tcaagatgca gcagatgttt taaatataag tgcggacgaa 87181 ttggcgccgc cagaaaaata gaacaaatga aaggaggaga aaaattgttc aaaatcggag 87241 atattcaatt gaaaaaccgg gttgtgctcg cacctatggc tggtgtctgc aactctgcgt 87301 tcagattgac tgtaaaggaa ttcggagccg gattggtatg cgctgaaatg gtcagtgaca 87361 aagcgatcct ttacaacaat gcaagaacaa tgggtatgct ttatattgat gaacgtgaga 87421 aaccactgag ccttcaaatt ttcggaggaa aaaaggaaac ccttgtggaa gcggcgaagt 87481 ttgtagacca aaacacaact gctgatatca ttgatattaa catgggatgt cccgtgccga 87541 agattacaaa atgcgatgcg ggagccaaat ggcttctcga tcctgataag atttacgaaa 87601 tggtttctgc agtagtggat gctgttaata agccagttac agtgaaaatg agaatgggct 87661 gggatgaaga ccacattttc gcagtgaaaa atgcacaggc tgtagaacgt gcgggcggta 87721 aagcagtggc gcttcacggc cgtacgagag tgcagatgta cgaaggaacg gcaaactggg 87781 atatcatcaa agaagtaaaa caatcagtat cgattccggt tatcggaaac ggcgatgtta 87841 agacaccgca ggatgctaag cgtatgctcg atgagacagg agtagacggg gtcatgatcg 87901 gacgcgctgc attgggtaac ccgtggatga tttaccgtac ggttcagtat cttgaaacag 87961 gtaaattaaa agaagagccg caagtacgcg aaaaaatggc cgtatgcaaa ctgcatcttg 88021 accgcctgat tgacttaaaa ggtgaaaacg tagcggtaag agaaatgaga aagcacgctg 88081 catggtatct gaaaggcgtg aaaggcaatg cgaacgttcg taatgaaatc aatcattgcg 88141 agacgagaga agagtttgta cagcttttag atgcatttac ggttgaagtt gaggcaaaag 88201 agcttcaaaa tgcaaaagta ggataatact cacctctatt tgctgctcac tgctagtttt 88261 acgctggcag tttttctgct tttttcatga aacaatatct gtaatggagt gataacaatg 88321 agtcaagaag agcataacca tgaagaattg aatgatcagc tgcaagtcag acgcgataaa 88381 atgaatcagc tgagagataa cggcatcgat ccattcggcg cacgttttga aagaactcat 88441 cagtctcaag aagttatttc ggcatatcaa gatctaacca aagaagagtt agaagaaaaa 88501 gcgattgaag ttacaatcgc aggccgcatg atgacaaaac gcggcaaagg aaaagccggc 88561 tttgcccatc ttcaggattt agaaggccaa atccaaatct acgtaagaaa agacagtgtc 88621 ggtgacgacc aatatgaaat cttcaagtct tctgacctcg gtgatcttat cggcgtaacc 88681 ggaaaagtct tcaaaacaaa tgtaggcgaa ttgtctgtta aagcaacttc ctttgaattg 88741 ctgacaaaag cgcttcgtcc gcttcctgac aaataccatg gtttaaaaga cgttgagcag 88801 cgctaccgtc agcgctatct ggatcttatc gtaaacccag acagcaaaca tacgttcatt 88861 acacgaagca agatcattca agctatgaga aggtaccttg atgatcatgg atacttagaa 88921 gtagaaacac ctacaatgca cagcattcct gggggagctt ctgcacgtcc gtttatcact 88981 caccacaacg cgttagacat tccactctat atgcgtattg ctatcgaact gcacctaaaa 89041 cgtctaattg tcggcggttt agaaaaagta tatgaaatcg gccgtgtttt ccgtaacgaa 89101 ggtgtctcta cacgccataa ccctgaattt acaatgattg agttatatga agcatatgcg 89161 gactataaag atatcatgag cttaactgaa aaccttgtcg ctcatatcgc ccaagaagtg 89221 cttggcacaa ctacgattca atacggggaa gagcaaatcg accttaaacc ggagtggaaa 89281 agaatccata tggttgacgc agtcaaagaa gcgaccggcg ttgatttctg ggaagaggtt 89341 actgttgagc aggcgcgtga atatgcaaaa gaacatgaag tagaaattaa agactctatg 89401 acagtaggcc atatcatcaa cgaattcttc gaacaaaaaa ttgaagaaac gcttattcag 89461 ccaacgttta tttacgggca tcctgtagaa atttctcctc ttgctaagaa aaaccctgag 89521 gacccgcgtt ttacagaccg ttttgagctg tttatcgttg gccgtgaaca tgccaacgcg 89581 tttacagagc tgaatgatcc tattgatcaa agagaacgct ttgaagcgca attaaaagag 89641 cgtgaagccg gtaatgatga agctcattta atggatgaag actttgttga agctctggaa 89701 tacggtatgc cgccaacagg aggtttaggc atcggtatcg accgtctggt tatgctgctg 89761 acgaatgccc cttctattcg cgatgtgctg ttattcccgc aaatgagaca acgctaataa 89821 aaaagagcgg tatcctccat agggaaagga tgccgctctt tttaaatccc ttagtatttc 89881 ttcaaaaaaa ctattgcact attatttact aggtggtata ttattattcg ttgccgctaa 89941 acaaggcgat aacgaaaaaa agaacttcaa aaaaagttat tgacttcact gagtcaacga 90001 gttataataa taaagtcgct tgaacgaagt gaacaaaatg atctttgaaa actaaacaag 90061 acaaaacgta cctgttaatt cagtttttaa aaatcgcaca gcgatgtgcg tagtcagtca 90121 aactacttta tcggagagtt tgatcctggc tcaggacgaa cgctggcggc gtgcctaata 90181 catgcaagtc gagcggacag atgggagctt gctccctgat gttagcggcg gacgggtgag 90241 taacacgtgg gtaacctgcc tgtaagactg ggataactcc gggaaaccgg ggctaatacc 90301 ggatggttgt ttgaaccgca tggttcaaac ataaaaggtg gcttcggcta ccacttgcag 90361 atggacccgc ggcgcattag ctagttggtg aggtaatggc tcaccaaggc aacgatgcgt 90421 agccgacctg agagggtgat cggccacact gggactgaga cacggcccag actcctacgg 90481 gaggcagcag tagggaatct tccgcaatgg acgaaagtct gacggagcaa cgccgcgtga 90541 gtgatgaagg ttttcggatc gtaaagctct gttgttaggg aagaacaagt gccgttcgaa 90601 tagggcggta ccttgacggt acctaaccag aaagccacgg ctaactacgt gccagcagcc 90661 gcggtaatac gtaggtggca agcgttgtcc ggaattattg ggcgtaaagg gctcgcaggc 90721 ggtttcttaa gtctgatgtg aaagcccccg gctcaaccgg ggagggtcat tggaaactgg 90781 ggaacttgag tgcagaagag gagagtggaa ttccacgtgt agcggtgaaa tgcgtagaga 90841 tgtggaggaa caccagtggc gaaggcgact ctctggtctg taactgacgc tgaggagcga 90901 aagcgtgggg agcgaacagg attagatacc ctggtagtcc acgccgtaaa cgatgagtgc 90961 taagtgttag ggggtttccg ccccttagtg ctgcagctaa cgcattaagc actccgcctg 91021 gggagtacgg tcgcaagact gaaactcaaa ggaattgacg ggggcccgca caagcggtgg 91081 agcatgtggt ttaattcgaa gcaacgcgaa gaaccttacc aggtcttgac atcctctgac 91141 aatcctagag ataggacgtc cccttcgggg gcagagtgac aggtggtgca tggttgtcgt 91201 cagctcgtgt cgtgagatgt tgggttaagt cccgcaacga gcgcaaccct tgatcttagt 91261 tgccagcatt cagttgggca ctctaaggtg actgccggtg acaaaccgga ggaaggtggg 91321 gatgacgtca aatcatcatg ccccttatga cctgggctac acacgtgcta caatggacag 91381 aacaaagggc agcgaaaccg cgaggttaag ccaatcccac aaatctgttc tcagttcgga 91441 tcgcagtctg caactcgact gcgtgaagct ggaatcgcta gtaatcgcgg atcagcatgc 91501 cgcggtgaat acgttcccgg gccttgtaca caccgcccgt cacaccacga gagtttgtaa 91561 cacccgaagt cggtgaggta accttttagg agccagccgc cgaaggtggg acagatgatt 91621 ggggtgaagt cgtaacaagg tagccgtatc ggaaggtgcg gctggatcac ctcctttcta 91681 aggatatttt acggaatata agaccttggg tcttataaac agaacgttcc ctgtcttgtt 91741 tagttttgaa ggatcattcc ttcgaaacgt gttctttgaa aactagataa cagtagacat 91801 cacattcaag taatacaaga tatcacatag tgattctttt taacggttaa gttagaaagg 91861 gcgcacggtg gatgccttgg cactaggagc cgatgaagga cgggacgaac accgatatgc 91921 ttcggggagc tgtaagcaag ctttgatccg gagatttccg aatggggaaa cccaccactc 91981 gtaatggagt ggtatccata tctgaattca taggatatga gaaggcagac ccggggaact 92041 gaaacatcta agtacccgga ggaagagaaa gcaaatgcga ttccctgagt agcggcgagc 92101 gaaacgggat tagcccaaac caagaggctt gcctcttggg gttgtaggac actctgtacg 92161 gagttacaaa ggaacgaggt agatgaagag gtctggaaag gcccgccata ggaggtaaca 92221 gccctgtagt caaaacttcg ttctctcctg agtggatcct gagtacggcg gaacacgtga 92281 aattccgtcg gaatccggga ggaccatctc ccaaggctaa atactcccta gtgaccgata 92341 gtgaaccagt accgtgaggg aaaggtgaaa agcaccccgg aaggggagtg aaagagatcc 92401 tgaaaccgtg tgcctacaag tagtcagagc ccgttaacgg gtgatggcgt gccttttgta 92461 gaatgaaccg gcgagttacg atcccgtgca aggttaagca gaagatgcgg agccgcagcg 92521 aaagcgagtc tgaatagggc gcatgagtac gtggtcgtag acccgaaacc aggtgatcta 92581 cccatgtcca gggtgaagtt caggtaacac tgaatggagg cccgaaccca cgcacgttga 92641 aaagtgcggg gatgaggtgt gggtaggggt gaaatgccaa tcgaacctgg agatagctgg 92701 ttctctccga aatagcttta gggctagcct caaggtaaga gtcttggagg tagagcactg 92761 attggactag gggcccctac cgggttaccg aattcagtca aactccgaat gccaatgact 92821 tatccttggg agtcagactg cgagtgataa gatccgtagt cgaaagggaa acagcccaga 92881 ccgccagcta aggtcccaaa gtatacgtta agtggaaaag gatgtggagt tgcttagaca 92941 accaggatgt tggcttagaa gcagccacca tttaaagagt gcgtaatagc tcactggtcg 93001 agtgactctg cgccgaaaat gtaccggggc taaacgtatc accgaagctg cggactgttc 93061 ttcgaacagt ggtaggagag cgttctaagg gctgtgaagc cagaccggaa ggactggtgg 93121 agcgcttaga agtgagaatg ccggtatgag tagcgaaaga ggggtgagaa tcccctccac 93181 cgaatgccta aggtttcctg aggaaggctc gtccgctcag ggttagtcgg gacctaagcc 93241 gaggccgaaa ggcgtaggcg atggacaaca ggttgatatt cctgtaccac ctcctcacca 93301 tttgagcaat ggggggacgc aggaggatag ggtaagcgcg gtattggata tccgcgtcca 93361 agcagttagg ctgggaaata ggcaaatccg tttcccataa ggctgagctg tgatggcgag 93421 cgaaatatag tagcgaagtt cctgattcca cactgccaag aaaagcctct agcgaggtga 93481 gaggtgcccg taccgcaaac cgacacaggt aggcgaggag agaatcctaa ggtgatcgag 93541 agaactctcg ttaaggaact cggcaaaatg accccgtaac ttcgggagaa ggggtgctct 93601 gttagggtgc aagcccgaga gagccgcagt gaataggccc aggcgactgt ttagcaaaaa 93661 cacaggtctc tgcgaagccg taaggcgaag tataggggct gacgcctgcc cggtgctgga 93721 aggttaagag gagcgcttag cgtaagcgaa ggtgcgaatt gaagccccag taaacggcgg 93781 ccgtaactat aacggtccta aggtagcgaa attccttgtc gggtaagttc cgacccgcac 93841 gaaaggcgca acgatctggg cactgtctca acgagagact cggtgaaatt atagtacctg 93901 tgaagatgca ggttacccgc gacaggacgg aaagaccccg tggagcttta ctgcagcctg 93961 atattgaatg ttggtacagc ttgtacagga taggtaggag ccttggaaac cggagcgcca 94021 gcttcggtgg aggcatcggt gggatactac cctggctgta ttgaccttct aacccgccgc 94081 ccttatcggg cggggagaca gtgtcaggtg ggcagtttga ctggggcggt cgcctcctaa 94141 aaggtaacgg aggcgcccaa aggttccctc agaatggttg gaaatcattc gcagagtgta 94201 aaggcacaag ggagcttgac tgcgagacct acaagtcgag cagggacgaa agtcgggctt 94261 agtgatccgg tggttccgca tggaagggcc atcgctcaac ggataaaagc taccccgggg 94321 ataacaggct tatctccccc aagagtccac atcgacgggg aggtttggca cctcgatgtc 94381 ggctcatcgc atcctggggc tgtagtcggt cccaagggtt gggctgttcg cccattaaag 94441 cggtacgcga gctgggttca gaacgtcgtg agacagttcg gtccctatcc gtcgcgggcg 94501 caggaaattt gagaggagct gtccttagta cgagaggacc gggatggacg caccgctggt 94561 gtaccagttg ttctgccaag ggcatcgctg ggtagctatg tgcggacggg ataagtgctg 94621 aaagcatcta agcatgaagc ccccctcaag atgagatttc ccattccgca aggaagtaag 94681 atccctgaaa gatgatcagg ttgataggtc tgaggtggaa gtgtggcgac acatggagct 94741 gacagatact aatcgatcga ggacttaacc atatttttga atgatgtcac atctgttatc 94801 tagttttgag agaacactct caatttgttt ggtggcgata gcgaagaggt cacacccgtt 94861 cccataccga acacggaagt taagctcttc agcgccgatg gtagtcgggg gtttccccct 94921 gtgagagtag gacgccgcca agcaattgca cgttagtgca attatggagg attagctcag 94981 ctgggagagc atctgcctta caagcagagg gtcggcggtt cgagcccgtc atcctccacc 95041 attatgccgg tgtagctcaa ttggtagagc aactgacttg taatcagtag gttgggggtt 95101 caagtcctct tgccggcacc acttttatat gatataatac tcaagtctct tgtagaagag 95161 ccattagctc agttggtaga gcatctgact tttaatcaga gggtcgaagg ttcgagtcct 95221 tcatggctca ccattttacg cgggtgtggc ggaattggca gacgcgctag acttaggatc 95281 tagtgtcttt atgacgtggg ggttcaagtc ccttcacccg cattatatag gataacagtt 95341 agaaaaactg gacatcctgt ctgcggaagt agttcagtgg tagaacacca ccttgccaag 95401 gtgggggtcg cgggttcgaa tcccgtcttc cgctccaact ataccatcca cgccggggtg 95461 gtggaattgg cagacacaca ggacttaaaa tcctgcggta ggtgactacc gtgccggttc 95521 aagtccggcc ctcggcatta tgttttgcgc ccgtagctca attggataga gcgtttgact 95581 acggatcaaa aggttagggg ttcgactcct ctcgggcgcg ccatatcttt taatagaata 95641 gataggaaat cgggaagtag ctcagcttgg tagagcacat ggtttgggac catggggtcg 95701 caggttcgaa tcctgtcttc ccgaccattt ttttatgggg ccttagctca gctgggagag 95761 cgcctgcttt gcacgcagga ggtcagcggt tcgatcccgc taggctccac caaaagtttt 95821 taaaaaagtt gttgactttg aagaagtgac gttgtatact aataaagttg ctttaacaaa 95881 gcggacaaac aaaatgatct ttgaaaacta aacaagacaa aacgtacctg ttaattcagt 95941 ttttaaaaat cgcacagcga tgtgcgtagt cagtcaaact actttatcgg agagtttgat 96001 cctggctcag gacgaacgct ggcggcgtgc ctaatacatg caagtcgagc ggacagatgg 96061 gagcttgctc cctgatgtta gcggcggacg ggtgagtaac acgtgggtaa cctgcctgta 96121 agactgggat aactccggga aaccggggct aataccggat ggttgtttga accgcatggt 96181 tcaaacataa aaggtggctt cggctaccac ttacagatgg acccgcggcg cattagctag 96241 ttggtgaggt aacggctcac caaggcaacg atgcgtagcc gacctgagag ggtgatcggc 96301 cacactggga ctgagacacg gcccagactc ctacgggagg cagcagtagg gaatcttccg 96361 caatggacga aagtctgacg gagcaacgcc gcgtgagtga tgaaggtttt cggatcgtaa 96421 agctctgttg ttagggaaga acaagtaccg ttcgaatagg gcggtacctt gacggtacct 96481 aaccagaaag ccacggctaa ctacgtgcca gcagccgcgg taatacgtag gtggcaagcg 96541 ttgtccggaa ttattgggcg taaagggctc gcaggcggtt tcttaagtct gatgtgaaag 96601 cccccggctc aaccggggag ggtcattgga aactggggaa cttgagtgca gaagaggaga 96661 gtggaattcc acgtgtagcg gtgaaatgcg tagagatgtg gaggaacacc agtggcgaag 96721 gcgactctct ggtctgtaac tgacgctgag gagcgaaagc gtggggagcg aacaggatta 96781 gataccctgg tagtccacgc cgtaaacgat gagtgctaag tgttaggggg tttccgcccc 96841 ttagtgctgc agctaacgca ttaagcactc cgcctgggga gtacggtcgc aagactgaaa 96901 ctcaaaggaa ttgacggggg cccgcacaag cggtggagca tgtggtttaa ttcgaagcaa 96961 cgcgaagaac cttaccaggt cttgacatcc tctgacaatc ctagagatag gacgtcccct 97021 tcgggggcag agtgacaggt ggtgcatggt tgtcgtcagc tcgtgtcgtg agatgttggg 97081 ttaagtcccg caacgagcgc aacccttgat cttagttgcc agcattcagt tgggcactct 97141 aaggtgactg ccggtgacaa accggaggaa ggtggggatg acgtcaaatc atcatgcccc 97201 ttatgacctg ggctacacac gtgctacaat ggacagaaca aagggcagcg aaaccgcgag 97261 gttaagccaa tcccacaaat ctgttctcag ttcggatcgc agtctgcaac tcgactgcgt 97321 gaagctggaa tcgctagtaa tcgcggatca gcatgccgcg gtgaatacgt tcccgggcct 97381 tgtacacacc gcccgtcaca ccacgagagt ttgtaacacc cgaagtcggt gaggtaacct 97441 tttaggagcc agccgccgaa ggtgggacag atgattgggg tgaagtcgta acaaggtagc 97501 cgtatcggaa ggtgcggctg gatcacctcc tttctaagga tattttacgg aatataagac 97561 cttgggtctt ataaacagaa cgttccctgt cttgtttagt tttgaaggat cattccttcg 97621 aaacgtgttc tttgaaaact agataacagt agacatcaca ttcaagtaat acaagatatc 97681 acatagtgat tctttttaac ggttaagtta gaaagggcgc acggtggatg ccttggcact 97741 aggagccgat gaaggacggg acgaacaccg atatgcttcg gggagctgta agcaagcttt 97801 gatccggaga tttccgaatg gggaaaccca ccactcgtaa tggagtggta tccatatctg 97861 aattcatagg atatgagaag gcagacccgg ggaactgaaa catctaagta cccggaggaa 97921 gagaaagcaa atgcgattcc ctgagtagcg gcgagcgaaa cgggatcagc ccaaaccaag 97981 aggcttgcct cttggggttg taggacactc tgtacggagt tacaaaggaa cgaggtagat 98041 gaagaggtct ggaaaggccc gccataggag gtaacagccc tgtagtcaaa acttcgttct 98101 ctcctgagtg gatcctgagt acggcggaac acgtgaaatt ccgtcggaat ccgggaggac 98161 catctcccaa ggctaaatac tccctagtga ccgatagtga accagtaccg tgagggaaag 98221 gtgaaaagca ccccggaagg ggagtgaaag agatcctgaa accgtgtgcc tacaagtagt 98281 cagagcccgt taacgggtga tggcgtgcct tttgtagaat gaaccggcga gttacgatcc 98341 cgtgcaaggt taagcagaag atgcggagcc gcagcgaaag cgagtctgaa tagggcgcat 98401 gagtacgtgg tcgtagaccc gaaaccaggt gatctaccca tgtccagggt gaagttcagg 98461 taacactgaa tggaggcccg aacccacgca cgttgaaaag tgcggggatg aggtgtgggt 98521 aggggtgaaa tgccaatcga acctggagat agctggttct ctccgaaata gctttagggc 98581 tagcctcaag gtaagagtct tggaggtaga gcactgattg gactaggggc ccctaccggg 98641 ttaccgaatt cagtcaaact ccgaatgcca atgacttatc cttgggagtc agactgcgag 98701 tgataagatc cgtagtcgaa agggaaacag cccagaccgc cagctaaggt cccaaagtat 98761 acgttaagtg gaaaaggatg tggagttgct tagacaacca ggatgttggc ttagaagcag 98821 ccaccattta aagagtgcgt aatagctcac tggtcgagtg actctgcgcc gaaaatgtac 98881 cggggctaaa cgtatcaccg aagctgcgga ctgttcttcg aacagtggta ggagagcgtt 98941 ctaagggctg tgaagccaga ccggaaggac tggtggagcg cttagaagtg agaatgccgg 99001 tatgagtagc gaaagagggg tgagaatccc ctccaccgaa tgcctaaggt ttcctgagga 99061 aggctcgtcc gctcagggtt agtcgggacc taagccgagg ccgaaaggcg taggcgatgg 99121 acaacaggtt gatattcctg taccacctcc tcaccatttg agcaatgggg ggacgcagga 99181 ggatagggta agcgcggtat tggatatccg cgtccaagca gttaggctgg gaaataggca 99241 aatccgtttc ccataaggct gagctgtgat ggcgagcgaa atatagtagc gaagttcctg 99301 attccacact gccaagaaaa gcctctagcg aggtgagagg tgcccgtacc gcaaaccgac 99361 acaggtaggc gaggagagaa tcctaaggtg atcgagagaa ctctcgttaa ggaactcggc 99421 aaaatgaccc cgtaacttcg ggagaagggg tgctctgtta gggtgcaagc ccgagagagc 99481 cgcagtgaat aggcccaggc gactgtttag caaaaacaca ggtctctgcg aagccgtaag 99541 gcgaagtata ggggctgacg cctgcccggt gctggaaggt taagaggagc gcttagcgta 99601 agcgaaggtg cgaattgaag ccccagtaaa cggcggccgt aactataacg gtcctaaggt 99661 agcgaaattc cttgtcgggt aagttccgac ccgcacgaaa ggcgcaacga tctgggcact 99721 gtctcaacga gagactcggt gaaattatag tacctgtgaa gatgcaggtt acccgcgaca 99781 ggacggaaag accccgtgga gctttactgc agcctgatat tgaatgttgg tacagcttgt 99841 acaggatagg taggagcctt ggaaaccgga gcgccagctt tggtggaggc atcggtggga 99901 tactaccctg gctgtattga ccttctaacc cgccgccctt atcgggcggg gagacagtgt 99961 caggtgggca gtttgactgg ggcggtcgcc tcctaaaagg taacggaggc gcccaaaggt 100021 tccctcagaa tggttggaaa tcattcgcag agtgtaaagg cacaagggag cttgactgcg 100081 agacctacaa gtcgagcagg gacgaaagtc gggcttagtg atccggtggt tccgcatgga 100141 agggccatcg ctcaacggat aaaagctacc ccggggataa caggcttatc tcccccaaga 100201 gtccacatcg acggggaggt ttggcacctc gatgtcggct catcgcatcc tggggctgta 100261 gtcggtccca agggttgggc tgttcgccca ttaaagcggt acgcgagctg ggttcagaac 100321 gtcgtgagac agttcggtcc ctatccgtcg cgggcgcagg aaatttgaga ggagctgtcc 100381 ttagtacgag aggaccggga tggacgcacc gctggtgtac cagttgttct gccaagggca 100441 tcgctgggta gctatgtgcg gacgggataa gtgctgaaag catctaagca tgaagccccc 100501 ctcaagatga gatttcccat tccgcaagga agtaagatcc ctgaaagatg atcaggttga 100561 taggtctgag gtggaagtgt ggcgacacat ggagctgaca gatactaatc gatcgaggac 100621 ttaaccatat ttttgaatga tgtcacatct gttatctagt tttgagagaa cactctcaat 100681 ttgtttggtg gcgatagcga agaggtcaca cccgttccca taccgaacac ggaagttaag 100741 ctcttcagcg ccgatggtag tcgggggttt ccccctgtga gagtaggacg ccgccaagca 100801 agcttaaacc cagctcaatg agctgggttt tttgtatttt ggtttattgg tatcataaaa 100861 ttccacttaa ctgtataata taataacttt ataccgaatt ttaaatcagc aatcaggttt 100921 tgtggaccgg gaaaatggaa ataatgaagg atagagcgag aaagttgaaa attctcgaga 100981 aacggcttat agtaagatta aagtcaaata tagtcaaagt cagtaaagga gggggttgag 101041 tgggacataa tatttctgac atcattgaac aatatttaaa acgagtgtta gatcaaaatg 101101 gcaaggaaat tttagagatt aaacgaagtg aaattgcaga taaatttcaa tgcgttcctt 101161 cccaaataaa ttatgtcatc aacaccagat ttacaagcga aagaggatat attgttgaga 101221 gcaaacgcgg gggcggcggt tacatcagaa tcattaaaat taaaatgaac aatgaagttg 101281 tcctgatcaa taatataatt tctcaaatta atacccattt gtctcaagca gcctctgatg 101341 acattatttt aaggctatta gaagacaagg taatttcaga aagagaagca aaaatgatgg 101401 tcagcgtaat ggaccgctca gttttacaca ttgacttacc tgaacgtgat gaattaagag 101461 cgagaatgat gaaggcaatg ctgacttctt taaaattaaa ataagcgggt gaaaagattg 101521 atttgtcaag agtgccacga gagaccagcc acttttcact ttacaaaggt tgttaacgga 101581 gaaaaaatag aagttcatat ttgtgaacaa tgtgccaaag aaaatagtga ttcatatggt 101641 ataagtgcaa atcagggttt ctctattcat aatttacttt cgggtttact gaacatggat 101701 tcttcatttc aaaatgcagg aactcaaatg ttcagtcact cggagcaaat atctgcttgt 101761 ccgaaatgcg gaatgacttt tcagcaattc agaaaaattg gccgttttgg atgttctgaa 101821 tgttacaaaa catttcatag caacattaca ccaatcctac gtaaagtgca cagcggaaac 101881 actgtgcatg caggtaagat accgaaacga ataggcggca atcttcatgt cagacggcag 101941 attgatatgc taaaaaagga attagaatcc ttaatccatc aagaagaatt tgaaaatgca 102001 gctcatgtaa gagatcaaat tcgtttatta gaacaatcac tcaaaagtac agatagtgag 102061 gaggaacagg agtaatgtcg ctaaagcatt ttattcagga cgcactaagc agttggatga 102121 agcagaaagg acctgaaagt gacattgtac tcagcagccg catacgttta gcaagaaact 102181 ttgagcatat tcggttccct acgcggtatt ccaatgaaga agcctcatcc atcatacagc 102241 aatttgaaga tcagttttca gagcaagaaa ttcccggaat cggcaaattt gttttgatta 102301 gaatgaatga tgcacagcct ttagaaaagc gtgtacttgt tgaaaaacat ctaatcagcc 102361 cgaatttgac agagtctcct tttggcggct gtttgctttc tgaaaatgag gaagtaagcg 102421 tcatgctaaa tgaagaggac catattagaa ttcagtgtct tttccctgga tttcagcttt 102481 tagaagcaat gaaagccgca aaccaggtcg acgactggat tgaagaaaaa gttgattatg 102541 cattcaatga gcaaagagga tacttaacca gctgtcctac aaacgtaggt actggtttaa 102601 gggcttcggt catgatgcat ctgccggcgc tggttttaac taggcaaata aatcgaatta 102661 taccggcaat taatcaatta ggcttagttg ttagaggaat ttatggggaa ggcagcgaag 102721 cagtagggaa tatctttcaa atttcaaatc agatcacgct tggtaagtca gagcaggata 102781 ttgtagagga tcttaacagt gttgctgctc agttgattga acaagaacga tctgcccgag 102841 aagcgattta tcaaacttct aaaatcgaac ttgaggatcg ggtatatcgg tcatatgggg 102901 tcttgtctaa ttgccggatg atagaatcga aagaaactgc aaagtgcctt tcagatgttc 102961 ggttaggcat agacttaggc ataataaaag gactttcaag caacatactt aacgaactta 103021 tgattttgac gcagccaggg tttttacagc aatactcggg aggcgctttg cgaccgaacg 103081 aaagggacat tcgaagagcg gctctcatca gagaacggct tcacttagaa atgaatggga 103141 aaagacagga ggatgaatcg atatgatgtt tggaagattt acagaacgag ctcaaaaagt 103201 actggcgcta gcacaggaag aagcacttcg gttaggtcat aataacattg gcactgagca 103261 tattttatta ggactggtaa gagaaggaga gggcattgct gctaaagctc ttcaagcgct 103321 tggactcggt tcagaaaaaa ttcagaaaga agtagaaagt ttgatcgggc gcgggcagga 103381 aatgtctcaa acgattcatt atactcctag agctaaaaaa gtcattgagc tttcaatgga 103441 tgaggcaaga aaactcggtc attcttatgt gggaacagaa catattcttc ttggtctgat 103501 tcgtgaagga gaaggtgttg ctgcgagagt tctgaataat ctcggtgtca gcttaaataa 103561 agcaagacag caggtgctcc agcttctagg aagtaatgaa acaggatcat cagcggcagg 103621 aacaaacagc aatgcgaata cgcctacgct tgacagcttg gcaagagact taactgctat 103681 tgcgaaggaa gacagccttg accctgtaat cggcagaagc aaggagatcc agcgtgtcat 103741 tgaagtgtta agccgcagaa cgaaaaacaa ccctgttctc attggggaac caggtgtagg 103801 taaaacggct atcgcagaag gtttggcaca gcaaattatc aataatgaag tacccgaaat 103861 tttgcgtgat aaacgtgtga tgacattaga catgggaaca gttgttgccg gcacaaaata 103921 ccgcggagaa tttgaggatc gcctgaagaa ggtcatggat gaaattcgcc aggcaggaaa 103981 tatcattcta ttcatcgatg agctccatac attaatcggg gcaggcggag cagaaggtgc 104041 tattgatgca tctaatattt taaaaccttc acttgctcgt ggcgaactcc aatgtattgg 104101 tgcaacgact cttgatgagt accgtaaata tattgaaaaa gatgcagcac tggaacgccg 104161 ttttcagccg attcaggttg atcagccatc tgtagatgaa agtattcaaa ttttacaagg 104221 tctgcgtgac agatacgaag cccaccaccg cgtttctatc actgatgatg ccattgaagc 104281 tgcggttaag ctttctgaca gatatatttc tgaccgcttc cttccggata aagcaattga 104341 cttgatcgat gaagcgggtt caaaggtgag actgcgctca tttacaacgc ctcctaactt 104401 aaaagagctt gagcagaagc ttgatgaggt tcgtaaagag aaggatgcgg cagtgcaaag 104461 ccaagagttt gaaaaagctg cttccttgcg tgatactgaa caacgcctgc gcgagcaagt 104521 agaggatacg aagaaatcat ggaaagagaa gcaagggcag gaaaactcag aggttactgt 104581 ggatgatatt gcgatggttg tatccagctg gaccggtgtg cctgtatcta aaatcgccca 104641 aactgaaact gataagcttc tcaatatgga aaacattctt cactcccgtg tcatcggcca 104701 ggatgaagca gttgtagcgg ttgcaaaagc cgtcagacgt gcaagagcag gattgaaaga 104761 tcctaaacgc ccaatcggct cattcatttt cttaggccct acaggtgtag gtaaaacaga 104821 acttgcacga gcacttgctg aatccatttt tggcgatgaa gaatccatga tcagaattga 104881 tatgtctgaa tacatggaaa aacattcaac ttcaagactt gttggttcac ctccgggtta 104941 tgtgggatat gatgaaggcg gtcaattgac agagaaagtc agaagaaaac cttactctgt 105001 cgtgcttctt gatgagatcg agaaagcgca ccctgatgtc ttcaatatcc ttctgcaagt 105061 tcttgaagac ggacgattga ctgattctaa aggacgcaca gtcgatttcc gcaataccat 105121 tctgatcatg acatcaaacg tcggagcaag tgagctaaaa cgcaataaat atgtcggctt 105181 taacgttcag gatgaaactc aaaatcataa agacatgaaa gataaagtga tgggtgaatt 105241 aaaacgagcg ttcagacctg agttcatcaa ccgtattgat gaaatcattg tcttccattc 105301 acttgagaaa aaacatctca ctgagattgt gtcattaatg tctgatcaat taacgaaacg 105361 cctgaaagaa caagatcttt ctatcgaatt gacagatgct gcaaaagcga aagtcgcgga 105421 agagggcgtt gacctggaat acggtgcccg tccgttaaga agagcgatcc aaaaacatgt 105481 cgaggatcgt ttatctgaag aactcctcag aggaaatatt cataaaggac agcatattgt 105541 tcttgatgta gaagatggcg aatttgtcgt aaaaacgact gctaaaacga attaatatag 105601 aagacggaaa tgaggcatac agcatgtaag tgtatgcctc actttcatat caagaaatag 105661 aacaagggag aggtcttaca ctatatatgg ctaaaacaaa atcgaagttc atctgccaat 105721 cctgcggcta cgagtctcca aaatggatgg ggaaatgtcc gggctgtggt gcttggaata 105781 caatggtgga agaaatgatt aaaaaagcac cggccaatcg gagagcggct ttttctcatt 105841 ctgttcaaac tgtacagaaa ccttcaccta ttacatcaat cgaaacatca gaagaacccc 105901 gcgtcaaaac ccagcttggc gagtttaaca gagtactcgg cggaggtgtc gttaaaggct 105961 ccctcgtttt aattggcggt gatcctggta tcggaaagtc aacgctatta ctgcaggttt 106021 ccgctcaatt atcaggctca tcaaacagtg tcctgtatat ttcgggagaa gaatctgtaa 106081 agcaaacgaa gctgcgagca gaccgtctcg gcattaataa tccgtcactg catgttttat 106141 ctgaaaccga tatggagtat atttcgtctg ctatacaaga gatgaatcca tcgtttgtcg 106201 ttgttgactc tattcaaacg gtttaccaaa gcgatattac atctgctcca ggcagtgtgt 106261 cacaggtcag agaatgtacc gctgagctga tgaaaattgc aaaaacaaaa ggtattccga 106321 tttttatcgt agggcacgtg acgaaagaag ggtctattgc aggtccgaga ctgttggagc 106381 atatggttga cactgtttta tattttgaag gagaacgcca ccatactttc cgtattttgc 106441 gggctgtaaa aaaccgtttc ggatctacaa acgaaatggg cattttcgaa atgcgggaag 106501 aggggctcac tgaggttttg aatccttcgg aaattttctt agaagaacgc tctgctggtt 106561 ccgcaggctc gagtatcact gcctctatgg agggcactag accgattctc gttgaaattc 106621 aggcactcat ctcgccaaca agttttggca acccaaggcg tatggcaacg ggaatagacc 106681 ataacagggt ttctctgtta atggctgtgt tagaaaaaag agttggactg ctgctgcaaa 106741 atcaggatgc ttatttgaaa gtggctggcg gcgttaagct tgatgaaccg gcaattgatc 106801 ttgcgattgt gattagtatt gcatcaagct ttagagacac acctccaaat cctgcagatt 106861 gttttattgg agaagtggga ttaaccggag aagtccggcg ggtttcaaga attgaacagc 106921 gtgtgaaaga agcggcaaag cttggtttta aacgcatgat catacccgcg gcaaatctgg 106981 atggatggac aaaaccaaaa gggattgagg ttatcggagt agcaaatgtt gcagaagcgc 107041 ttcgtacttc attaggagga taatagatgg aaaaagagaa aaaaggggcg aaacacgagt 107101 tagacctgtc atctatattg cagtttgttg ctccgggtac accgctcaga gcggggatgg 107161 aaaacgtctt gagagcaaat acaggcggtc tgattgttgt tggatataat gataaagtaa 107221 aagaagtggt ggacggcggc tttcacataa acacggcttt ttctccggcg catttatatg 107281 agctggctaa aatggatgga gcgatcattt taagtgattc tggtcaaaag atcctatacg 107341 cgaatactca gctgatgccg gatgccacaa tttcttcatc agaaacagga atgcggcaca 107401 gaactgccga aagagtagct aagcaaactg gctgtcttgt aatcgccatt tctgaaagaa 107461 gaaatgtcat aacgttatat caggaaaaca tgaagtatac actaaaagac ataggattta 107521 ttttaaccaa ggcgaaccaa gccattcaaa cacttgaaaa atataagaca atcctcgata 107581 aaacgattaa tgcactgaac gcgttagagt ttgaggaact tgttaccttc agtgatgtct 107641 tgtctgtcat gcatcgttat gaaatggtac tgagaatcaa aaacgaaatt aatatgtata 107701 tcaaagagct ggggacagaa gggcatctga tcaaactgca agtcattgaa ttgattacgg 107761 atatggaaga agaggccgct ttatttatta aggactatgt aaaagaaaag attaaagatc 107821 cgtttgttct cttgaaggag ctgcaggata tgtccagtta tgatctgctg gatgattcca 107881 ttgtgtataa gcttctcggt taccctgctt ctactaatct tgatgattat gtattgccga 107941 gaggatacag gctgttaaat aagataccgc gtcttccgat gccgattgtt gaaaatgttg 108001 tagaagcatt tggagtcctg ccaaggatta ttgaggcgag tgcagaagaa ttagatgaag 108061 tagagggaat cggtgaagta cgagcccaaa aaatcaaaaa aggattaaaa cgcctgcaag 108121 agaagcatta tttagacaga caactgtgat ttcggttaaa accttatgaa tacgggtata 108181 ttaatgttgg tttttgttta ttctgatatt cgtaggatgc ataagacttt gtgaaattaa 108241 aatgttaaaa aaggaggtgg gggtatgtta aaacgaatag ttcaggcgtt cttcattatt 108301 tttggcggcg ttgttggtat atttttgata cctgaattgt ttgtactgtt aaatatacag 108361 gacatacctt taataacaaa cgcatatacg tctgcggcaa taggagcaat tatctttttt 108421 ctcatcagta tatggggtac agaatacgtt gtgaactggg tgaagtggat agaggattca 108481 ttgttaaaag cgccggttcc agatttgtta tttggaagtc ttggcttagt ttttggactt 108541 ataattgctt atcttatcgt aaatgttatt cctttagaca atatacctta ccgcatattc 108601 agcacaataa ttcctgtatt tttggctttc ttcctcggtt atctcggctt ccaggtgggc 108661 tttaagaaaa aggatgaatt gatcagcctg ttttccattt ccgccagaat gcaaaagaaa 108721 aaaggaacag ctgatgaaga acatgaggtt caagacaaga agctgaaaat tttggacact 108781 agtgttatta ttgatgggag aatagcagat atttgtcaga ctggtttttt agagggagtt 108841 atcgtgattc cgcagtttgt ccttgaggaa ttgcagcata ttgcagactc ttcagatgtt 108901 ttaaaacgaa acagaggacg ccgcggtctt gatatcctga accgcattca gaaagaatta 108961 gacattgaag ttgaaattta cgaaggcgac tttgaagata ttcaggaggt tgacagcaag 109021 ctcgtcaaac ttgctaagct gacatccggg gtcgttgtga cgaatgattt taatttaaat 109081 aaagtgtgcg agcttcagaa ggtagcagta ttaaacatta atgaccttgc caatgcggtt 109141 aagcctgttg tgcttcctgg cgaggaaatg aatgttcagg tcattaagga cgggaaagag 109201 cataatcagg gagttgccta cttggatgac ggtacgatga ttgtcgttga agaaggacgg 109261 aattatatcg gcaagcatat tgatgtactc gtcacaagtg tgctgcagac agcagcggga 109321 cgaatgattt ttgcgaagcc taagctgttg gagaaggcgc tgtaaaggga gaagaaacaa 109381 tgagttatga tgtggtgatt cctgcagccg gacagggaaa gcggatgaag gcagggagaa 109441 ataaactgtt cattgagctg aagggagacc cggtgatcat acacacgtta agagtgtttg 109501 acagccaccg gcagtgcgat aaaatcattt tggtgattaa cgagcaggag cgggagcact 109561 ttcagcaatt gctgtccgat tacccgtttc aaacttcaat tgagcttgtt gcaggcggag 109621 atgagcgaca gcacagtgtg tataaggggc tgaaagccgt aaagcaggaa aagattgtcc 109681 ttgtacatga cggtgcccgt ccatttataa aacatgaaca aattgacgaa ctgatcgcag 109741 aggcggaaca gacaggagcg gccatccttg ctgttccggt aaaagatacg attaaacgcg 109801 ttcaagattt acaagtcagt gagacgattg aacgttcaag cttgtgggct gtccaaacgc 109861 cacaagcttt tcgtctttct ttattgatga aggctcacgc tgaggccgag cgcaagggat 109921 ttttagggac ggatgacgcc agcctcgttg aacagatgga gggcggttcg gtccgtgttg 109981 tagaaggcag ctatacaaat attaagctga cgacgccaga cgatttgacg tcagctgaag 110041 ctatcatgga atcagaaagt gggaataaac atgtttagaa ttggacaagg atttgatgtg 110101 catcaattag tggagggccg tcctctcatt attggcggaa ttgaaatccc gtacgaaaaa 110161 gggctgcttg gccattctga tgcagacgta ttgttgcata ccgtcgctga cgcctgcctg 110221 ggagctgtgg gtgaaggaga cataggcaag cattttcctg acacagatcc cgagttcaag 110281 gacgcagatt ctttcaaatt acttcagcat gtctggggaa tcgtgaaaca gaaggggtat 110341 gtccttggga acattgattg caccatcata gcgcaaaagc cgaagatgct gccgtacata 110401 gaagatatga gaaaaagaat tgctgaaggc cttgaggcag atgtttctca agtaaatgta 110461 aaagcaacaa cgacagaaaa gcttggattt acaggccggg cggaaggaat agcggctcag 110521 gcgacagtac tgatacaaaa aggctaactt gttttgatgc cgggtctatt tggtggtaga 110581 atagattcat acatttttgc ctgaggccat acatgacatg aaaggaagta tttgaaaatg 110641 ggaaacgaag tacgcgtccg ttatgcaccg agtccaaccg gacatttgca tattggaaat 110701 gccagaacgg cgctttttaa ttatttattt gcccgcaatc aaggcggtaa gtttatcatt 110761 cgagttgagg atactgataa aaagcgcaat attgagggcg gagaacaaag ccagctgaat 110821 tatctgaagt ggctaggtat tgactgggat gagagtgtgg atgtcggagg agagtacggt 110881 ccataccgtc agtcagagcg taacgatatc tataaagtgt actatgaaga gcttcttgaa 110941 aaagggcttg cttataaatg ttactgtacg gaagaagagc ttgaaaaaga gcgtgaagaa 111001 cagattgccc gcggagaaat gcctcgttat tccggaaaac acagagacct gactcaggaa 111061 gaacaggaga aatttatcgc cgaaggcaga aaaccaagta ttcgtttccg tgtgccggaa 111121 ggaaaagtca tcgccttcaa cgacatcgta aaaggcgaaa tttcttttga atcagatggc 111181 atcggcgact tcgttattgt gaaaaaggac ggaacgccta cttataactt cgcggtagct 111241 attgatgact acttaatgaa aatgacacac gtgctgcgcg gtgaggatca tatttctaac 111301 acaccgaaac agattatgat ctatcaagca ttcgggtggg atattcctca gttcggacac 111361 atgacgctga ttgtaaacga aagccgtaaa aagctcagca aacgtgatga atccattatt 111421 caattcatcg agcagtacaa agagcttggc tacctgccag aagcgctgtt caactttatc 111481 ggcttgttag gctggtcacc ggttggagaa gaagagcttt tcacaaaaga gcagtttatt 111541 gaaatttttg atgtaaatcg tttatctaaa tcaccagctt tgtttgatat gcataagcta 111601 aaatgggtta acaaccaata tgtgaagaag ctggatcttg atcaggttgt tgaactgacg 111661 cttccgcatt tgcaaaaagc cggcaaagtt ggcactgagc tttctgctga agaacaagaa 111721 tgggttcgta aactgatttc cctgtatcat gagcaattaa gctacggtgc ggaaattgtt 111781 gagctgactg atttgttctt tacggatgag atcgagtata atcaagaagc gaaagctgtt 111841 ctggaagaag aacaggttcc tgaagtgctc agcacattcg cagcgaagct tgaagagctt 111901 gaggagttca ctccggataa tatcaaagca tcgatcaaag cagtgcagaa agaaactggc 111961 cataaaggga aaaaactgtt tatgccgatt cgtgttgctg taacagggca aactcacggt 112021 ccggaactgc cgcaatcaat tgaattgatc ggtaaagaga ctgcaattca gcgtttaaag 112081 aatatctaaa taaatgattg ttgacaggga agagtataaa gctttaggcc attacagaaa 112141 ggatcttcat tggctgagag agatccatga gccgggtttt agaagtgcgc ccttaagacc 112201 tttgaagaac gttttttgaa atcagtattc aaaggcggcc gccgccgtta caggctgaag 112261 ttgggagagc agaagtctgc ttttcaaaca gagtggaacc gcgcggttaa agcgtctctg 112321 tcatgtttac atgcagagac gcttttttta ttgggtagag gaaatcagat agagaaacgg 112381 ggggaagcat gtgtttttta gaatgctcaa agaagacatt gatactgtgt tcgatcaaga 112441 tcccgcagca agaagctatt ttgaagtgat tttaacttat tccggtttac atgctatatg 112501 ggcgcatcgg attgcacatg ctttatataa acgaaaattt tatttccttg cacgccttat 112561 atctcaagta agccgatttt ttaccgggat agaaatccac cccggcgcta caatcgggag 112621 aagatttttc atagaccacg gcatgggggt tgtcattggg gagacatgtg aaatcggcaa 112681 taacgtaacc gtttttcagg gggttaccct cgggggaacg ggaaaagaaa agggaaaaag 112741 gcacccaacg attaaagatg acgcattgat agccacaggt gctaaagtgc tcggttctat 112801 tacggtcggt gaaggctcaa agattggcgc tggttcagta gtgctgcatg atgttcctga 112861 tttttcaaca gttgtcggta tccctggacg ggtcgttgta caaaatggca agaaagtaag 112921 acgcgattta aaccatcagg atttgcccga tccagttgct gaccgcttta agtctttgga 112981 acagcagatt ttagagctga aggcagaact tgaagacaga aaagaaagga tcaatcaaaa 113041 atgacaatca cactttataa tacattgact agacagaagg aaacattcgt tcctcttgaa 113101 gagggaaaag tgaaaatgta tgtatgcgga cccacggttt acaattacat tcatatcggg 113161 aacgcgcgtc cggcaatcgt ttacgatacg gttcgaaact atttagagta taaaggctat 113221 gatgtgcagt atgtctctaa cttcacagac gtagacgata aattaattaa agcggcaaat 113281 gaactcggtg aggatgtacc caccatttca gagcgtttta ttaaagcata ctttgaagac 113341 gtaggtgcgc tcggctgccg aaaagccgac cttcatccgc gagtaatgga gaacatggat 113401 gccattatcg aattcgtaga tcagctcgtg aaaaagggct acgcatatga atcagaaggt 113461 gacgtatatt tcaaaaccag agcatttgaa gggtacggaa agctttctca gcaatcaatc 113521 gatgaactaa gatcaggtgc acgcatccgg gtcggcgaga aaaaagaaga tgctcttgat 113581 ttcgcactgt ggaaagcggc aaaagaagga gaaatctctt gggatagccc ttgggggaaa 113641 gggcgtccgg gctggcacat tgaatgctca gcaatggtga aaaagtatct cggtgaccag 113701 attgatatcc atgcgggcgg acaggattta acattccctc accatgaaaa cgaaattgcg 113761 caatctgagg cgctgacagg caaaacgttt gcgaagtact ggcttcataa tggttatatc 113821 aatattgata atgaaaaaat gtcaaaatca ctaggcaact ttgtgcttgt gcatgacatc 113881 attaaacagc atgatccgca gcttttgaga ttctttatgc tatctgttca ttatcgccat 113941 ccgattaact attcagaaga gcttctggag aatacgaaaa gcgcgttcag ccgtttaaaa 114001 acagcgtaca gcaatcttca gcaccgtctg aacagcagta cgaatttaac cgaagatgac 114061 gatcaatggc ttgaaaaggt tgaagaacac cgcaaagcat tcgaagaaga gatggacgat 114121 gattttaata cggcgaatgc catttcagtc ttgtttgact tagcgaaaca cgccaattat 114181 tatcttcaga aagatcatac ggctgatcat gtgattacgg cgtttattga gatgtttgac 114241 cgcattgttt ctgtcctcgg tttttcgttg ggtgagcagg aacttctcga tcaagagatt 114301 gaagacttaa tcgaaaagcg aaatgaagcg cgccggaatc gcgattttgc attgtcagac 114361 cagatccgcg accagctgaa aagcatgaat atcattcttg aagatacggc tcaaggcact 114421 cgctggaaac ggggagaata acagatgctt gaatttgata cgataaaaga ttctaagcag 114481 cttaacggtc ttgcgcttgc ttatataggt gatgccattt ttgaagtgta tgtcaggcat 114541 cacctgctta agcagggctt taccaaacca aatgatcttc ataagaaatc aagccggatt 114601 gtttcagcaa agtcacaggc tgagatccta ttttttctgc agaatcaatc attttttacg 114661 gaagaagagg aagcggtgct gaaaagaggc agaaatgcca agtcagggac aacacctaaa 114721 aatacagatg ttcagacgta ccgctacagt acagcatttg aagcgcttct gggctacctt 114781 tttctagaga aaaaagagga acgacttagt cagctcgtag ccgaagctat acaattcggg 114841 acgtcaggga ggaaaacaaa tgagtcagca acatgattac gtcataggga aaaatgcagt 114901 gatcgagacg ttaaaatctg atcggaagct gtataagctg tggatggcgg aaaacaccgt 114961 aaagggacaa gcacagcaag tgattgagct tgccaaaaag cagggaatca cgattcaata 115021 cgtcccgaga aaaaaactcg atcaaatggt gacaggacag catcagggcg tagtggcaca 115081 ggttgcagcg tatgaatatg cagaactgga cgatttatat aaagcagccg aagaaaaaaa 115141 tgaacagcct ttcttcctca ttctggacga gcttgaagac cctcataatc ttggttccat 115201 tatgaggaca gcagatgcgg tcggcgctca tggcatcgtc attccaaaac ggagagctgt 115261 cgggctgaca acaacagtgg caaaagcttc aacaggagca attgagcaca ttcctgtagc 115321 aagagtcacc aatttggcac ggacgttaga agagatgaaa gagcggggaa tctgggttgt 115381 cggaacggat gcgtccgcgc gtgaggattt ccgtaatatg gacggcaata tgcctttggc 115441 tctagtcatc ggaagtgaag gaaaagggat gggccgcctt gtgaaggaaa agtgcgattt 115501 tctcattaaa ctcccgatgg ccggaaaggt aacttcacta aatgcatctg tcgcggctgg 115561 tcttttgatg tatgaagtct accggaaacg aaaccctgtg ggagaataaa gacccatgga 115621 tatcctgtta gtagacgggt acaacatgat tggagcctgg ccgcagctga aggatttaaa 115681 agcgaacagt tttgaagagg cgagagacgt actgattcag aaaatggcgg aatatcaatc 115741 gtatacagga aacagggtta ttgttgtttt tgacgcgcat ctcgtaaaag ggcttgagaa 115801 aaaacagacc aaccatagag ttgaagtaat ttttacaaaa gaaaatgaga cggctgatga 115861 gcggatagaa aagctcgctc aggctttgaa taatattgcg actcaaattc acgttgcgac 115921 ctctgactat actgagcagt gggcgatttt cggacagggg gcattgcgga aatcggcccg 115981 ggagcttctg agagaggtag aaacgattga aaggcgaata gagagacggg taagaaaaat 116041 cacttccgaa aagccggcgg gtaaaattgc tttatcggaa gaggttttga aaacgtttga 116101 aaagtggagg cggggagact tagattaagt tgacgctttt ttgcccaata ctgtataata 116161 tttctatcta cgtgcgccgg ggggatcgga gtgaatctac agaacaacaa gggaaaattc 116221 aacaaagagc agttttgcca gttggaggac gagcaggtca ttgaaaaggt tcatgttggg 116281 gacagtgatg cgttagatta cttgattacg aagtaccgaa actttgttcg ggcaaaagca 116341 agatcctatt tcttaatagg ggcggacaga gaggatattg ttcaggaagg catgataggc 116401 ctctataagt ctattcgtga cttcaaagag gacaagctta cctcattcaa agcttttgca 116461 gaattatgta ttacccgcca aattattacc gcaataaaga cagctactcg ccagaaacac 116521 attcctttga attcctacgc ctcattagat aaaccgatct ttgatgaaga atcagaccga 116581 acgctgctgg atgtcatttc aggagcgaaa accttaaatc ctgaggaaat gatcattaat 116641 caggaagaat ttgatgatat tgaaatgaaa atgggagaac tattaagtga tttagagaga 116701 aaagtactcg tcttatatct cgacgggaga agttaccaag agatttctga tgaactgaac 116761 cgacatgtga aatcgatcga caatgccctt cagcgtgtga aacgcaagct ggagaagtac 116821 ttggaaattc gcgaaatcag tttgtaatag gaatttatgc tatattgaca gtatttttct 116881 gactatgata tgttactaaa gataagaact aatgtctatt tagaaaaagg tgtaatgaca 116941 tgagaaaaaa gattacgtta gcatgcaaga catgcggaaa ccgtaattat acgacaatga 117001 agagctctgc atcagcggct gagcgattag aagtaaagaa atactgcagt acttgcaatt 117061 cacatacagc tcatcttgaa acaaaatagt ttttgcgctt ttaaattgtg gaggtctttt 117121 acatgcgtat tatgaaattc tttaaagatg ttgggaaaga aatgaaaaag gtaagctggc 117181 ctaaaggaaa agagttaacg cgttatacca ttacggtaat ttcaacagtt atcttttttg 117241 ttatcttttt tgccctcctt gacacaggaa tttctcaatt aattcgttta atagttgaat 117301 aatgatcagc aatacgtgct ataatagatc ataatattac ttgccaaaac ccgttcagcg 117361 ggttttttat tgtggcttaa aatgaaagtt atcataggct tgccgcctat tttttgaagc 117421 gttatggtaa ttcactaaaa ccaaatgcgg ggagggaagg actggacagt cctgaataga 117481 atggaaaaga attggtatgt tgttcacacg tactctggtt atgagaataa agtaaaagcc 117541 aacttggaaa agcgtgttga atcaatgggg atgcaggata aaattttccg tgtagtcgta 117601 cccgaagaag aagaaacgga tatcaaaaac ggcaagaaaa aagtcgtgaa aaagaaagta 117661 ttccctggtt atgtgcttgt tgaaattgta atgacagacg actcttggta tgtcgtccgc 117721 aacacgccgg gcgttactgg attcgtagga tctgccgggt caggttcaaa accgacgccg 117781 cttcttccgg gggaagcaga aaccattctg aagagaatgg gcatggatga acgaaaaact 117841 gatattgact ttgaactgaa agagacagtg aaagtaatag acggaccttt tgctaacttt 117901 acaggatcaa ttgaagagat tgattatgat aaaagcaagg tcaaagtttt cgttaatatg 117961 tttggccgtg aaacgccggt tgagctggaa tttacccaaa tcgataaatt gtaatgtgaa 118021 aaaacttgaa attgctatat ataaatgata atatagcaaa ggtacgtctt ggacttatcc 118081 aaggcaacta gcatgatatt tcgtcattca tataaagaat gaaaccttga gtgggagggt 118141 ttaccctatt accacatcac ggacttaagg aggtgtgtct cgtggctaaa aaagtagtta 118201 aagttgtaaa attgcaaatt cctgctggaa aagctaaccc agcaccacca gttggacctg 118261 cacttggtca agccggtgtt aacatcatgg gattctgtaa ggagtttaac gctcgtacag 118321 ctgaccaagc tggtttaatc attcctgttg aaatttcggt ttacgaagac cgttcattta 118381 catttattac aaaaactcca cctgctgcag tattgcttaa aaaagcagct ggaattgagt 118441 ctggttctgg tgaaccaaac cgtaataaag tggcaaccgt taagcgcgat aaagtacgcg 118501 aaatcgctga aacgaaaatg cctgacttaa acgcagcaga cgttgaagcg gcaatgcgca 118561 tggttgaagg tactgcccgc agtatgggta ttgtaatcga ggattaattt gtttcttgtc 118621 gggttgcgag ttttaacaag ttcgcaaccc ttattcgtgg gaggttattc cgctataacc 118681 acataaggag gaaattttaa aatggctaaa aaaggtaaaa agtacgttga agctgctaag 118741 cttgtagacc gttctaaagc ttacgacgtc tctgaagcag tagctctcgt taaaaaaaca 118801 aacacagcta aattcgacgc tacagttgaa gtggctttcc gtttaggggt tgaccctcgt 118861 aaaaacgacc agcaaatccg tggagcagtt gtgcttccaa acggaactgg taaaactcag 118921 cgcgttctcg ttttcgcaaa aggcgaaaaa gcgaaagaag ctgaagctgc tggtgcagat 118981 ttcgtaggcg atactgacta catcaacaaa attcaacaag gctggttcga tttcgatgtt 119041 atcgtagcta cacctgacat gatgggtgaa gttggtaaaa tcggtcgtgt acttggacca 119101 aaaggtttaa tgccgaaccc taaaactggt acagttactt tcgaagttga aaaagctatc 119161 ggcgaaatca aagctggtaa agttgaatac cgcgttgata aagctggaaa cattcatgtt 119221 cctatcggta aagtttcttt cgaggatgaa aaacttgttg agaacttcac aacaatgtac 119281 gatacaatcc ttaaagctaa acctgctgca gctaaaggcg tttacgtgaa aaacgttgct 119341 gtaacttcta ctatgggacc tggtgtcaaa gtagactctt caacttttaa cgtaaaataa 119401 tattgacatg acatcaacat tctgatatta ttcaaaatgt tgtaaaatag aatatcattt 119461 ataccgtaga cagtaggggc ctaaccgctt aattatccta ccgaggtgta tattatcaca 119521 gctattacgt tacgtatgct tgtatataca gcctccatgt ctcatggagg ctttttatat 119581 ggaatccgtc gtctcagtcg tgatcaccta acggtataag tgttacacaa gaatctacag 119641 gaggtgtaac catgagcagc gcaattgaaa caaaaaaagt tgttgttgaa gaaattgctt 119701 ctaaactgaa agaaagtaaa tcaacgatca tcgttgacta tcgcggactt aacgtttctg 119761 aagtaactga acttcgtaaa cagcttcgcg aagctaacgt tgagttcaaa gtttacaaaa 119821 atacgatgac tcgccgtgcg gttgaacaag ctgagcttaa tggtttgaat gatttcttaa 119881 ctggaccgaa cgcgatcgca ttcagcactg aagatgttgt cgctccggct aaagttctta 119941 atgacttcgc taaaaatcac gaagctcttg aaatcaaagc tggcgttatc gaaggtaaag 120001 tttctactgt tgaagaagtg aaagctcttg ctgaacttcc atcacgcgaa ggcttgcttt 120061 ctatgttgct tagcgtactt caagctccag ttcgcaacct tgctcttgct gcaaaagctg 120121 tggcagaaca aaaggaagaa caaggcgctt aatctaatca gtttttcata aattaaaaca 120181 aaatggagga attacaaatg gctttaaata tcgaagaaat cattgcttcc gttaaagaag 120241 caactgtact tgaattgaac gacctagtaa aagcaatcga agaagaattt ggcgtaactg 120301 ctgctgctcc tgtagctgta gctggcggag ctgctgctgg cggagctgct gaagagcaaa 120361 gcgaattcga tcttatcctt gctggtgcag gatctcaaaa aatcaaagtt atcaaagttg 120421 tacgtgaaat cactggtctt ggcttgaaag aagctaaaga gcttgttgac aacactccaa 120481 aaccacttaa agaaggtatt gctaaagaag aagctgaaga gcttaaagct aaacttgaag 120541 aagttggcgc ttctgtagaa gttaagtaat cttcacttac ctgtagggga agctcgcttt 120601 tatgaggcga gctttttctt tgccattctt taagccatga aaaaaggagg ttctaataat 120661 gagtgagcac tattattcag aaaaaccttc agtaaaaagc aacaagcaaa cctggtcttt 120721 taggcttcgg aataaagatt tcacgtttac cagcgacagc ggggtttttt ctaaaaaaga 120781 agttgatttc ggctcccgcc tgctgattga ttcttttgaa gagcctgagg ttgagggcgg 120841 cattttagat gtaggctgcg gatacggccc gattggttta tcgctcgcca gcgactttaa 120901 agaccggacc atccacatga ttgacgttaa tgagagagcc gtagaactat caaatgaaaa 120961 tgcggaacag aacggaataa caaacgttaa gatttatcaa agcgatttgt tttcaaacgt 121021 tgattctgct caaacatttg cttctattct tacaaatccc ccaatccgag ccggaaaaaa 121081 agttgtccat gctatctttg agaaaagcgc tgaacactta aaagcttcag gtgaattgtg 121141 gatcgtcata cagaaaaagc aaggcgcgcc ttctgccatt gaaaagctcg aggaactgtt 121201 cgatgaagtt tccgtcgttc aaaaaaagaa aggctattat atcataaaag caaaaaaagt 121261 ttgactcggt attttaacta tgttaatatt gtaaaatgcc aatgtatata ttttgcttga 121321 tatgatgaat tgtcaatatc tatgtataaa ttatacaagt atggaaatgc taataaaatc 121381 ggtatttgtt tttggatgtg gttttcttaa ttagaaaccc ttttttcttt tgtcttgtaa 121441 aagtattttc tttctttgga agaaatgctt attacacata taatacgcat gatttgaggg 121501 gtgaatcagt tgacaggtca actagttcag tatggacgac accgccagcg cagaagctat 121561 gctcgcatta gcgaagtgtt agaattacca aatctcattg aaattcaaac ctcttcttat 121621 cagtggtttc ttgatgaggg tcttagagag atgtttcaag acatatcacc aattgaggat 121681 ttcactggta acctctctct tgagttcatt gattatagtt taggtgagcc taaatatcct 121741 gtagaggaat caaaagaacg tgatgtgact tactcagctc cgctaagagt gaaggttcgt 121801 ttaattaaca aagaaactgg agaggtaaaa gaccaagatg tcttcatggg tgatttccct 121861 attatgacag atacaggtac ttttatcatt aacggtgcgg aacgtgttat cgtttcccag 121921 cttgttcggt ctccaagtgt atatttcagt ggtaaagtag acaaaaacgg taaaaaaggt 121981 tttaccgcaa ctgtcattcc aaaccgtggc gcatggttag aatacgaaac tgatgcgaaa 122041 gatgttgttt atgtccgcat tgatcgcaca cgtaagttgc cggttacggt tcttttgcgt 122101 gctctcggct tcggctccga tcaagagatt cttgatctca taggagaaaa cgaatacctg 122161 cgaaatacgc ttgataaaga taacacagaa aacagcgaca aagcgttgct ggaaatttac 122221 gagcgtctcc gtcctggaga gccgcctaca gtagaaaatg cgaaaagctt gcttgattct 122281 cgtttctttg atccgaaacg atacgatctt gccaatgtag gacgctataa aattaataaa 122341 aaacttcata ttaagaatcg cctcttcaat cagagacttg ctgaaacgct tgttgatcct 122401 gaaacaggag aaatccttgc tgaaaaaggc cagattcttg atagaagaac gcttgataaa 122461 gtactgccat acttagaaaa cggaatcggt tttagaaagc tgtatccgaa tggcggcgtt 122521 gttgaagatg aagtgactct tcaatcaatt aaaatctttg ctccgactga tcaagaagga 122581 gaacaggtta tcaatgtaat cggcaatgct tacatcgaag aagagattaa aaacatcacg 122641 cctgctgata ttatttcttc aatcagctac ttcttcaacc tgctgcacgg agtaggcgac 122701 acagatgata tcgatcatct tggaaaccgc cgtttacgtt ctgtaggcga gcttctccag 122761 aaccaattcc gtatcggttt aagccgtatg gagcgtgtgg ttcgtgagag aatgtcaatt 122821 caagatacga atacaattac gcctcagcag ctgatcaata ttcgtcctgt tattgcgtcc 122881 attaaagagt tctttggaag ctcacagctt tctcaattca tggatcagac gaacccgctt 122941 gctgaattaa cgcacaagcg tcgtctgtca gcattaggac cgggcggatt gacacgtgag 123001 cgtgccggaa tggaagtgcg tgacgttcac tactcccact atggccgtat gtgtccgatt 123061 gaaacgcctg agggcccgaa catcggtttg atcaactcac tatcatctta tgcaaaagta 123121 aaccgttttg gctttattga aacgccatat cgccgcgttg accctgaaac agggaaggta 123181 acgggcagaa tcgattactt aactgctgat gaagaggata actatgttgt cgctcaagcg 123241 aatgctcgtc ttgatgacga aggcgccttt attgatgaca gcatcgtagc tcgtttccgc 123301 ggggagaaca ccgttgtttc cagaaatcgt gtagactaca tggatgtatc gcctaagcag 123361 gttgtatctg ctgcgacagc atgtatcccg ttcttagaaa acgatgactc caaccgtgcc 123421 ctcatgggag cgaacatgca gcgtcaggct gtgcctttga tgcagccgga agcgccattt 123481 gttggaactg gtatggaata cgtatcagga aaagactctg gtgccgctgt tatttgtaaa 123541 caccctggta tcgttgaacg cgtagaagcc aaaaacgttt gggttcgccg ttatgaagaa 123601 gtagacggtc aaaaagtaaa aggaaacctg gataaataca gcctgctgaa atttgtccgc 123661 tctaaccaag gtacgtgcta caaccagcgt ccgatcgtaa gtgtcggcga tgaagtggta 123721 aaaggagaaa tccttgctga cggtccttct atggagcttg gtgaacttgc acttggccgt 123781 aacgtaatgg tcggcttcat gacgtgggat ggctacaact atgaggatgc catcatcatg 123841 agtgaacgcc tagtgaagga tgatgtttat acatctatcc acattgaaga atacgaatca 123901 gaagcacgtg atacgaaact tggacctgaa gaaatcactc gcgatattcc aaacgtcggt 123961 gaagatgcgc ttcgcaatct tgatgaccgc ggaatcatcc gtattggggc agaagtaaaa 124021 gacggagatc ttcttgttgg taaagtaacg cctaaaggcg taactgaact gactgccgaa 124081 gaacgccttc ttcacgccat ctttggcgag aaagcccgcg aggttcgtga tacttctctt 124141 cgtgtgcctc atggcggcgg cggaattatc catgacgtta aagtcttcaa ccgtgaagac 124201 ggagacgaac ttcctccagg tgttaaccag ttagtacgcg tatatatcgt tcagaaacgt 124261 aagatttctg aaggggataa aatggccggt cgtcacggta acaaaggtgt tatctctaag 124321 attcttcctg aagaggatat gccttacctt cctgacggca caccaattga tatcatgctt 124381 aacccgctgg gcgtaccatc acgtatgaac atcgggcagg tattggaact tcacatgggt 124441 atggccgctc gttaccttgg cattcacatt gcatctcctg tatttgacgg agcgcgagaa 124501 gaggatgtct gggaaacact tgaagaagcc ggcatgtctc gtgacgccaa aacagtgctt 124561 tacgacggac gtactggaga gccgtttgat aaccgtgtat ctgtcggtat catgtacatg 124621 atcaaactgg ctcacatggt tgacgataaa cttcatgcac gctctacagg cccttactca 124681 cttgttacgc agcagcctct tggcggtaaa gcgcaatttg gcggacagcg ttttggtgag 124741 atggaggttt gggcacttga agcttacggt gcggcttaca ctcttcaaga aattctgact 124801 gttaagtctg atgacgtggt tggacgtgtg aaaacatacg aagccatcgt taaaggcgac 124861 aatgttcctg aaccaggtgt tccggaatca ttcaaagtat taatcaaaga acttcaaagc 124921 ttaggtatgg atgtcaaaat cctttctggt gatgaagaag aaatagaaat gagagattta 124981 gaagacgaag aagatgcgaa acaagctgac ggcctggcat tatcaggtga tgaagagccg 125041 gaagaaacag catctgcaga cgttgaacgc gatgtagtaa caaaagaata atctctagtt 125101 ataaaggcaa gtgacatcgg ttaatccgaa gataaaaagg gaggtaggcc ccttgctaga 125161 tgtgaacaat tttgagtata tgaacatcgg tcttgcttca ccagataaaa tccgttcatg 125221 gtcttttggt gaagtgaaaa agcctgaaac gataaactat cgtacgttaa aacctgaaaa 125281 ggacggtcta ttctgcgaac gcattttcgg accgactaag gactgggaat gtcattgcgg 125341 gaagtacaag cgagttcgtt ataaaggcgt agtttgtgac cgctgcggag tcgaagtaac 125401 acgggctaaa gtccgtcgtg agagaatggg gcacattgaa ctggctgccc cagtttccca 125461 catttggtat ttcaaaggta ttccaagccg tatgggtctt gtgctggata tgtcacctcg 125521 tgctttagaa gaagtcattt actttgcttc ttacgttgta actgatccgg cgaatacacc 125581 gcttgaaaag aaacagcttc tgtctgagaa agaataccgt gcttatcttg ataaatacgg 125641 taataaattc caagcatcta tgggtgctga agcaattcat aaacttcttc aagatatcga 125701 tcttgtaaaa gaagttgata tgttaaaaga agagctgaaa acttcacaag gacaacgccg 125761 tactcgtgcg atcaaacgtc ttgaagtttt agaagccttc cgtaactcag gaaacaagcc 125821 ttcttggatg atccttgatg tgcttcctgt tattcctccg gagcttagac cgatggttca 125881 gctagatggc ggacgttttg cgacttctga tttgaatgac ctttatcgtc gtgtcatcaa 125941 ccgtaacaat cgtttgaaac gccttttgga ccttggtgcg cctagcatca tcgttcaaaa 126001 cgaaaagcgt atgcttcaag aggctgtcga tgccctaatt gacaacggcc gccgcggacg 126061 ccctgtaaca ggtcctggaa acagaccgtt aaaatctctt tctcacatgc tgaaagggaa 126121 gcaaggccgt ttccgtcaaa accttcttgg taaacgtgtc gattactccg gacgttctgt 126181 aatcgttgtt ggtcctcatt tgaaaatgta ccaatgcgga ttaccgaagg aaatggcact 126241 tgaacttttc aaacctttcg ttatgaaaga acttgttgaa aaaggtcttg ctcacaacat 126301 taagagtgcg aaacgcaaaa ttgagcgcgt acagcctgaa gtttgggatg tactagaatc 126361 agttattaag gagcatccgg tactgctgaa ccgtgcccct acacttcaca gattaggtat 126421 ccaggcgttt gaaccaacgc ttgttgaagg acgcgcaatc cgtcttcacc cgctcgtatg 126481 tacagcttac aacgctgact ttgacggtga ccaaatggcg gttcacgtac cattatctgc 126541 tgaagcacaa gctgaagcac gcatcttgat gcttgctgct caaaacatct tgaaccctaa 126601 agatggtaaa ccggttgtaa caccgtctca ggatatggta ctaggtaact attacctgac 126661 acttgagcgt gccggtgctg tcggtgaagg tatggtcttc aagaatacag acgaagcgct 126721 tcttgcttat caaaacggat atgttcacct tcatacgaga gtagctgttg cagctaactc 126781 acttaagaat gtgacattta ccgaagaaca gcgctcaaaa ttgttaatta caactgtcgg 126841 taagcttgtc ttcaatgaaa ttcttccgga atcattccct tacatgaatg aaccaacgaa 126901 gagcaacatt gaagagaaaa cacctgaccg tttcttctta gaaaaaggtg ctgatgttaa 126961 agctgttatc gcacagcagc caatcaatgc gccgtttaaa aaaggcattc tgggtaaaat 127021 catcgcggaa atctttaaac gattccatat tacggaaacg tctaaaatgc ttgaccgcat 127081 gaaaaaccta ggtttcaaat attcaactaa agctggtatt acagttgggg tttctgacat 127141 cgtcgtactc gatgataaac aagaaattct tgaggaagcg caaagcaaag ttgacaacgt 127201 tatgaagcaa ttccgccgcg gtcttatcac tgaagaagaa cgctatgaga gagtcatctc 127261 tatctggagt gctgcaaaag acgttatcca aggcaaactg atgaaatcac ttgatgaact 127321 caacccgatc tacatgatga gtgactctgg tgcccgtggt aacgcatcta actttacgca 127381 gcttgccgga atgcgcggcc tgatggccaa cccggctgga cgtatcattg agttgccgat 127441 caaatcaagt ttccgtgaag gtctgacagt attggagtac tttatctcca cacacggtgc 127501 gcgtaaaggt cttgccgata ccgctcttaa aactgctgac tcaggttacc ttacacgccg 127561 tctcgttgac gttgctcagg atgttatcat ccgtgaaact gattgcggaa ctgaccgagg 127621 cattcttgct aagcctctta aagaaggaac tgaaacaatt gagcgcttag aagaacgctt 127681 aatcggacgt tttgcaagaa aacaagtgaa gcaccctgaa acaggtgaag tgcttgtgaa 127741 tgaaaacgaa ctgatcgatg aagataaagc actggagatt gtcgaagccg gcattgaaga 127801 agtgtggatc cgttctgcct tcacatgtaa tacgcctcat ggtgtatgta aacgatgcta 127861 tggccgaaat cttgcaactg gctccgatgt tgaagtcggt gaagctgtcg gaatcattgc 127921 tgcccaatca atcggtgagc ctggtacaca gttaacaatg cgtacattcc atacaggcgg 127981 ggttgccgga gacgatatca cacagggtct tccgcgtatc caagagcttt tcgaagcgcg 128041 taatccgaaa ggtcaggcaa caattacaga aatcgacggt acagtcgttg agatcaatga 128101 agttcgtgat aagcaacagg aaattgtggt tcaaggcgca gtggaaacac gttcttatac 128161 ggcaccttac aactcccgcc tgaaagtagc ggaaggagat aaaattactc gaggccaagt 128221 actgacagaa ggttcaatcg atccgaaaga acttcttaaa gtgactgacc tgacgactgt 128281 tcaagagtat cttctccatg aggttcaaaa ggtttaccgt atgcagggtg ttgaaatcgg 128341 tgataaacac gtagaagtaa tggttcgcca gatgcttcgc aaagtacgcg tgattgatgc 128401 cggtgacact gatgtgcttc caggtacatt gcttgatatt caccaattta ctgaagcgaa 128461 caaaaaggta ttgcttgaag gcaaccgacc agctacaggc cgtcctgtct tactcggtat 128521 tacaaaagca tctcttgaaa ctgattcatt cttatctgct gcttccttcc aggaaacaac 128581 acgtgtcctt acagatgcag cgatcaaagg taagcgtgac gagcttctcg gcttgaaaga 128641 gaatgttatc atcggtaagc ttgttccagc aggtacagga atgatgaaat accgtaaagt 128701 aaaaccagta tcaaatgttc agccgactga cgatatggtc ccggttgaat aactgattta 128761 actctgctga aagactgcaa aaacagtctt tcagcagata tatttatgaa aaagtcactc 128821 tatgagaaga acgaatctaa aaaatgtcat accttgttga cattcgtctc ctagaatgat 128881 aatataacca aggtgctcga aataaacctg ttactttgga ggatatgttt atgtcttatg 128941 ataaagtatc acaggccaaa tcaattatta ttggtacgaa gcaaacagtg aaagctctaa 129001 agcgaggttc agtaaaggaa gtagtcgttg caaaagacgc agatccgata ctcacgtcaa 129061 gtgttgtttc acttgctgaa gatcaaggta tctctgtctc aatggttgaa tccatgaaaa 129121 agctcggcaa agcctgcgga attgaggtag gagcagccgc tgttgccatt attttataac 129181 gtacttttgt ttttgcgtaa gattccatct tgtgtaaaga cattgttttt tgccttttga 129241 tgaaccacct gggtatgtgg gttataaaac gtaatgaagg gaggaaaaat tcatgcctac 129301 aattaatcag ctaattcgca aaggacgcgt gagtaaagta gaaaactcaa agtctcctgc 129361 acttaacaaa ggatacaaca gctttaaaaa agagcacact aacgtatctt ctccacaaaa 129421 acgcggggta tgtactcgtg ttggtacaat gacaccgaaa aaaccgaact cagcacttcg 129481 taaatatgct cgtgttcgtt tgactaacgg aatcgaggtt actgcttaca ttcctggtat 129541 cggtcacaac ctgcaagagc acagtgttgt acttatccgc ggcggacgtg taaaagactt 129601 accaggggta cgttaccaca tcgttcgtgg tgcgcttgat actgctggag ttgaaaaccg 129661 tgcacaaggc cgttctaaat acggtacgaa aaaacctaaa gcaaaataat atacgaaaat 129721 acgcataatt gatgaaggga ggatattcag atgccacgta aaggtcctgt agcaaaaaga 129781 gatgttttac ctgatccgat ttacaactct aagcttgtat ctcgtttaat caacaaaatg 129841 atgatcgatg gtaaaaaagg taagtctcaa acgatcctat acaagtcatt cgatatcatt 129901 aaagaacgta ctggcaatga tgcaatggag gttttcgaac aagcattgaa aaacatcatg 129961 cctgtacttg aagtaaaagc acgccgtgta ggtggtgcga actaccaagt tcctgtagaa 130021 gttcgtcctg aacgtcgtac gactcttgga cttcgctggt tagttaacta cgctcgtctt 130081 cgtggagaaa aaacgatgga agagcgttta gctaacgaaa tccttgacgc agctaacaac 130141 actggtgctg ctgttaagaa acgtgaagac actcataaga tggctgaagc aaacaaagca 130201 tttgctcact atcgctggta ggatttatag attaacaaaa cacaatttcc taataaggaa 130261 ggagaaatta cccaatggca agagagttct ccttagaaaa aactcgtaat atcggtatca 130321 tggctcacat cgatgccggt aaaacgacta ctacagaacg tatcttgttc tatactggtc 130381 gtatccacaa aattggtgaa actcatgaag gagcttcaca aatggactgg atggagcagg 130441 aacaagaacg tggtatcaca atcacttccg ctgcgactac tgcacagtgg aaaggatacc 130501 gcgtaaacat catcgatact ccaggacacg tagacttcac agttgaagtt gaacgttctc 130561 ttcgtgtact tgatggtgct gttgctgtac ttgacgcgca atcaggcgtt gagcctcaaa 130621 cagaaactgt ttggcgtcag gcaacaactt atggagtacc gcgtatcgtt tttgttaaca 130681 aaatggacaa aatcggtgca gacttccttt actctgtagg aactttaaga gaccgtcttc 130741 aagcaaacgc tcatgcaatt caattgccga tcggtgctga agataacttc gaaggtatca 130801 ttgaccttgt agaaaacgtt gcgtatttct acgaagatga cctcggaact cgttctgatg 130861 caaaagaaat ccctgaagag tacaaagagc aagctgaaga gcttcgcaac agccttattg 130921 aagctgtatg tgagcttgat gaagagctta tggataagta ccttgagggt gaagaaatca 130981 caattgacga gttaaaagca ggaattcgta aaggtacatt aaatgttgaa ttctaccctg 131041 ttcttgttgg ttctgccttc aaaaacaaag gtgttcaact agtacttgat gctgttcttg 131101 actaccttcc tgcaccaact gacgttgctg caatcaaagg tacacgtcct gatacaaatg 131161 aagagattga gcgtcattct tctgacgaag agccattctc tgcattagca tttaaagtta 131221 tgactgaccc ttacgttggt aagttgacgt tcttccgtgt gtactctgga acacttgatt 131281 ctggttcata cgtgaaaaac tctactaaag gcaaacgtga gcgtgttgga cgtattcttc 131341 aaatgcacgc taacagccgt gaagaaatct ctactgtata cgcaggggat atcgcagctg 131401 ctgtaggtct aaaagataca actactggag atactctatg tgatgagaag gatcttgtta 131461 tccttgagtc aatggaattc ccagaaccag ttatcgacgt tgctattgag cctaaatcaa 131521 aagctgacca agataaaatg ggtatcgctt tagcgaaact tgctgaagaa gatcctacat 131581 tccgtactca aacaaaccca gaaactggcc aaacgatcat ctctggtatg ggtgaacttc 131641 accttgatat cattgttgac cgtatgaaac gcgaatttaa agtagaagcc aatgttggtg 131701 ctcctcaagt tgcgtaccgt gaaacattcc gtaccggtgc aaaagttgaa ggtaaattcg 131761 tacgtcagtc tggtggacgc ggtcagttcg gacacgtttg gatcgaattc gaaccaaacg 131821 aagaaggcgc tggctttgaa tttgaaaatg cgattgtcgg tggggtcgtt cctcgtgaat 131881 acatcccagc tgttcaagca ggtctggaag atgcactcga aaatggtgta ctagcaggct 131941 tcccgcttat cgacattaaa gctaaacttt tcgacggttc ttaccatgat gttgactcaa 132001 acgaaatggc atttaaagtc gctgcttcta tggcattgaa aaatgcagtc agcaaatgta 132061 acccagttct tcttgaacca atcatgaaag tggaagtggt tattccagaa gaatatatgg 132121 gagatatcat gggtgatatc acttcacgtc gcggacgcgt agaaggtatg gaagcacgcg 132181 gtaacgctca agttgttcgt gctatggttc ctcttgctga aatgttcggt tacgctactg 132241 cacttcgttc taatacgcaa ggtcgcggta cgttcactat gcacatggat cactacgaag 132301 aagtgccgaa gagcgtcgca gaagaaatta tcaaaaaaaa taaaggcgaa taattgattt 132361 tgccgcttaa ctcaagtata actactattg taagatgagg aagtgaaagc tttctttcac 132421 ttcctatcac tctatacatt actaattaaa agctcttaag gaggatttta gaatggctaa 132481 agaaaaattc gaccgttcca aatcacatgc caatattggt acaattggac acgttgacca 132541 tggtaaaaca actttaactg ctgctatcac aacagtactt cataagaaat ctggtaaagg 132601 tacagctatg gcgtacgatc aaattgatgg tgctccagaa gaacgcgagc gcggtatcac 132661 aatctctact gcacacgttg agtacgaaac tgaaactcgt cactatgcac acgttgactg 132721 cccaggacac gctgactatg ttaaaaacat gatcactggt gctgcgcaaa tggacggagc 132781 tatccttgta gtatctgctg ctgatggccc aatgccacaa actcgtgagc acatccttct 132841 ttctaaaaac gttggtgtac catacatcgt tgtattctta aacaaatgcg acatggtaga 132901 cgacgaagag cttcttgaac tagttgaaat ggaagttcgc gatcttctta gcgaatacga 132961 cttccctggt gatgatgtac cagttgttaa aggttctgct cttaaagctc ttgaaggaga 133021 cgctgagtgg gaagctaaaa tcttcgaact tatggatgcg gttgatgagt acatcccaac 133081 tccagaacgc gacactgaaa aaccattcat gatgccagtt gaggacgtat tctcaatcac 133141 tggtcgtggt acagttgcta ctggccgtgt agaacgcgga caagttaaag tcggtgacga 133201 agttgaaatc atcggtcttc aagaagagaa caagaaaaca actgttacag gtgttgaaat 133261 gttccgtaag cttcttgatt acgctgaagc tggtgacaac attggtgccc ttcttcgcgg 133321 tgtatctcgt gaagaaatcc aacgtggtca agtacttgct aaaccaggta caatcactcc 133381 acacagcaaa ttcaaagctg aagtttacgt tctttctaaa gaagagggtg gacgtcatac 133441 tccattcttc tctaactacc gtcctcagtt ctacttccgt acaactgacg taactggtat 133501 catccatctt ccagaaggcg tagaaatggt tatgcctgga gataacactg aaatgaacgt 133561 tgaacttatt tctacaatcg ctatcgaaga aggaactcgt ttctctattc gtgaaggcgg 133621 acgtactgtt ggttcaggcg ttgtttctac aatcactgag taatagtatg gttttaaacg 133681 agacccctgt gggtctcgtt ttttgtttgc ttatcttttt cttgtataat aggatctatc 133741 atattcgagg ggttaatatt tatgattcct gaaaagaaat caatcgcaat catgaaagaa 133801 ctaagcattg gaaatacaaa gcaaatgctg atgattaatg gagttgacgt gaaaaatcca 133861 ttgctgcttt ttttacatgg cgggccggga acgccgcaaa tcggatatgt tagacattat 133921 caaaaagagc tggaacagta ttttacagta gttcattggg atcagagagg atcggggctt 133981 tcttattcta agcgaatttc gcatcactct atgacaataa atcacttcat taaagataca 134041 atccaagtca ctcaatggct tttagctcat ttttcaaaat caaaacttta cctagccggt 134101 cattcttggg gatcaatact ggcgcttcat gtgctgcagc agcgtcctga tttattttac 134161 acgtattatg gaatcagcca ggttgttaac ccgcaagatg aagaatcaac tgcttatcaa 134221 catattcgtg aaatttccga atcaaaaaaa gccagcatat tatctttcct tacacgtttc 134281 attggtgctc cgccttggaa gcaggatatc cagcacctta tctatcggtt ttgtgttgag 134341 ctaaccaggg gaggattcac tcaccgtcat cgtcaatctc tcgctgtatt atttcaaatg 134401 cttactggca atgagtatgg agtgcggaac atgcacagct tccttaatgg attgcgcttc 134461 agtaaaaaac atttaactga tgagttgtac cggtttaatg cttttacatc agttccttct 134521 attaaagtac cgtgtgtttt catttcaggg aaacatgact taattgttcc tgcagaaata 134581 tcgaaacagt attatcaaga acttgaggca cctgaaaagc gctggtttca atttgagaat 134641 tcagctcaca ccccgcatat tgaggagcca tcattattcg cgaacacatt aagtcggcat 134701 gcacgacacc atttatgata gatccttgat aaataagaaa aacccctgta taataaaaaa 134761 agtgtgcaaa tcatgcatat tttaaataag tcttgcaaca tgcgcctatt ttctgtataa 134821 tggtgtatgt tggtctttga ctgcgatgaa gtgagaggtt gctgacacac ccggccgctt 134881 tgccatggca aggtgttcag gtttttctca cggagaactg tctaacgtga tgtaggcgaa 134941 aaggagggaa aataatggca aaacaaaaaa ttcgtattcg tttgaaagca tatgatcata 135001 gaatccttga tcaatctgca gagaagattg ttgaaacggc aaaacgttct ggtgccagcg 135061 tatctggtcc gattccgttg ccaactgaaa aatcagttta cacaatcctt cgtgcggtgc 135121 acaaatacaa agattctcgt gagcaatttg aaatgcgtac acataaacgt ttaatcgaca 135181 ttgtgaaccc aacaccacaa actgttgatg ctcttatgcg attagactta ccatctggtg 135241 tcgatatcga aattaaactt taattctaaa atatagaatg atcttaatag gaggtgtgac 135301 gaatgaccaa aggaatctta ggaagaaaaa ttggtatgac gcaagtattc gctgagaatg 135361 gtgatcttat tccggtaact gttatcgagg ctgctccaaa cgttgttctt caaaagaaaa 135421 cagctgaaaa cgacggttac gaagcaatcc agcttggttt tgacgacaag cgtgaaaagc 135481 tttctaacaa acctgaaaaa gggcacgttg caaaagcgga aactgctcct aagcgcttcg 135541 ttaaagaatt acgcggagtg gaaatggatg cgtatgaagt tggtcaggaa gtcaaggttg 135601 aaattttctc tgctggagaa atcgtagatg taacaggagt atctaaaggt aaaggtttcc 135661 aaggtgcgat caagcgccac ggacaatctc gcggacctat gtctcacggt tcacgctacc 135721 accgtcgtcc tggttcaatg ggacctgtag atcctaaccg tgtattcaaa ggtaaattat 135781 tacctggacg tatgggcgga gagcaaatca ctgttcaaaa ccttgaaatc gtaaaagttg 135841 atgcagaacg caatcttctt ttgatcaaag gtaacgtacc tggtgcgaag aaatctttaa 135901 tcactgttaa aagtgctgtt aaatctaaat aattctctta ggaaaggagg aaattgatta 135961 tgccaaaagt agcattatac aaccaaaacg gttctactgc tggtgacatc gaattaaacg 136021 cttctgtatt tggtatcgaa ccaaatgaga gtgttgtatt cgacgctatt cttatgcaaa 136081 gagcttcctt acgtcaagga actcacaaag taaaaaatcg ttctgaagta cgcggcggag 136141 gtcgtaaacc atggcgtcaa aaaggtactg gacgtgcccg tcaaggttca atccgttcac 136201 cgcaatggcg cggaggtggt gtcgtattcg gcccaacacc acgcagctat tcttataaat 136261 tacctaaaaa agttcgccgc ttggcaatca aatcagtatt gtcttctaaa gtgatcgaca 136321 acaacatcat cgttcttgaa gatcttactc ttgatacggc taaaacaaaa gaaatggcag 136381 ctatccttaa aggattatct gttgagaaaa aagctttaat cgtaactgcg gatgcaaacg 136441 aagcagtagc attatctgct cgtaacattc ctggagttac tgttgttgaa gctaacggaa 136501 tcaacgtttt agacgttgtc aaccacgaga agcttctgat tacaaaagca gcggttgaaa 136561 aagtagagga ggtgcttgca taatgaaaga tcctcgtgat gttctaaagc gccccgtcat 136621 tactgaacgt tctgccgatt taatgactga aaaaaaatat acttttgaag ttgatgtaag 136681 agctaacaaa acagaagtga aagacgcggt tgaaagcatc tttggagtga aagttgacaa 136741 agtcaacatc atgaactaca aaggcaaatc aaaacgtgtt ggacgctaca ctggtatgac 136801 tagccgtcgc agaaaagcga tcgtaaaact tactgcagac agcaaagaaa tcgaaatttt 136861 tgaagcttaa ttatctgtaa aaagaaggag ggaaattcaa aatggcgatt aaaaagtata 136921 aaccgacctc taatggacgt cgtggcatga caacttcaga ttttgctgaa atcacgactg 136981 acaagccgga aaaatccttg cttgctcccc ttcacaaaaa aggcggacgt aacaaccaag 137041 gtaaattgac tgtacgtcac caaggtggcg gacataaacg ccaataccgt gttatcgact 137101 tcaaacgcga taaagatggt atacctggac gcgttgctac agttgaatac gatccaaacc 137161 gttcagctaa catcgctcta atcaactatg cagacggaga aaaacgttac attcttgctc 137221 ctaaaggaat tcaagtaggt actgaaatca tgtcaggtcc tgaagctgac attaaagtag 137281 gtaatgcact tccacttatc aacatccctg ttggtacagt tgtgcataac attgaattaa 137341 aacctggtaa aggcggacag cttgtacgtt cagctggtac atctgctcag gttcttggta 137401 aagaaggtaa atacgttctt gtacgtctta actctggtga agttcgcatg atcctttctg 137461 cttgccgtgc ttctatcggt caagtaggta acgaacagca cgaacttatc aacattggta 137521 aagctggacg ttctcgctgg aaaggcatcc gtcctacagt tcgtggttct gtaatgaacc 137581 ctaacgatca cccacacggt ggtggtgaag gacgtgcgcc aatcggacgt aaatcaccaa 137641 tgtctccatg gggcaaacca actcttggat tcaagactcg taagaaaaag aacaaatccg 137701 ataaatttat cgtacgtcgt cgtaaaaata aataacgggg ttgtctacgg ttcttttcgg 137761 accgtagtgc aatcacgaag ggaggttcca aaatggctcg cagcttaaaa aaaggaccat 137821 ttgtcgatgg acacttgatg actaaaatcg agaaattaaa tgaaacagac aagaaacaag 137881 tcgtaaaaac ttggtctcgt cgttctacta ttttcccaca gtttattggt cacacaatcg 137941 cagtctatga cggacgtaaa cacgtgcctg tattcatctc tgaagatatg gtagggcaca 138001 agttgggtga attcgctcca actcgtacgt acaaaggtca tgctagtgat gacaaaaaaa 138061 caagacgcta agagaggagg cttttaaatg caagctaaag ctgttgcaag aacagtccgt 138121 attgctcctc gtaaagcacg tctagtaatg gacctgattc gaggcaagca agtaggtgag 138181 gcagtatcaa tcttgaacct tacaccaaga gctgcttctc caattatcga gaaagtatta 138241 aaatccgcta ttgcaaatgc tgagcataac tatgaaatgg acgctaacaa cctggttatt 138301 tctcaagcat tcgttgacga aggccctacg ttaaaaagat tccgcccacg tgctatggga 138361 cgtgcgagcc aaatcaacaa acgtacgagc cacattacaa tcgttgtatc agaaaagaag 138421 gagggataag tagtgggtca aaaggtaaat ccagtcggtc ttcgtatcgg agtcattcgt 138481 gattgggaat ctaagtggta cgctggtaaa gattacgctg acttcctgca cgaagattta 138541 aaaattcgtg aatacattag caaacgcctt tctgacgctt ctgtttctaa agtagaaatt 138601 gagcgtgcag caaaccgcgt taacattacg atccacacag ctaagcctgg tatggttatc 138661 ggtaaaggcg gttctgaagt cgaagcactt cgcaaagccc ttaacagcct tactggcaag 138721 cgtgtacaca ttaacattct tgaaatcaaa agagcagatc ttgatgcaca gctagttgct 138781 gacaacatcg ctcgtcaatt agaaaaccgt gtttctttcc gccgtgcgca gaaacaacaa 138841 atccaacgta ctatgcgtgc tggagcacaa ggtgtgaaaa caatggtttc tggtcgtctt 138901 ggcggtgcag atatcgctcg ttctgaatac tacagtgaag gaactgttcc attgcacaca 138961 ttacgtgcgg acattgacta tgcaacatct gaagctgata ctacttacgg taagcttggt 139021 gtaaaagtct ggatctatcg tggagaggtt cttcctacta agaagaaaaa tgaggaagga 139081 ggaaaataat atgttattac caaaacgcgt taaatatcgc agagagcatc gcggaaaaat 139141 gcgtggccgt gcgaaaggcg gtactgaagt acatttcgga gaattcggta tccaagctct 139201 agaagcttct tggattacta accgtcaaat cgaagctgca cgtattgcga tgactcgtta 139261 catgaaacgt ggcggtaaag tttggatcaa aattttccct tctaaacctt acactgctaa 139321 accacttgag gtacgtatgg gatccggtaa aggggctcca gaaggttggg tagctgttgt 139381 aaaaccgggc aaagttttat ttgaaatttc tggtgtgtct gaagaggttg ctcgtgaagc 139441 gcttcgcctt gcatctcaca aattgccaat taaaacgaag ttcgtaaaac gtgaagaaat 139501 tggtggtgaa tcaaatgaaa gctaatgaaa ttcgtgacct taccactgct gaaattgaac 139561 aaaaagtaaa gtctcttaaa gaagaacttt tcaatcttcg ctttcaatta gcgacaggac 139621 aacttgaaaa tactgctcgc attcgtgaag tgcgcaaagc tatcgcgcgc atgaaaactg 139681 tgattcgtga aagagaaatt gctgctaata aataatcact gaggggaggt cgtgagcatg 139741 agcgaacgta accaacgcaa agtttaccaa ggccgtgttg tttctgacaa aatggataaa 139801 accattactg ttgttgttga gacatacaaa aaacatacac tttacggtaa acgcgtaaaa 139861 tactcaaaaa aattcaaagc acatgatgaa aataatcaag ctaaaatcgg tgacatcgtt 139921 aagatcatgg aaactcgtcc attgtctgca actaagcgtt tccgtctagt tgaagttgtc 139981 gaagaagctg ttattatcta ataaagttcg gaattctttt tccgaaggga ggtaacaaat 140041 aatgattcaa caagagactc gtttaaaagt agctgacaac tctggcgcac gtgaagtact 140101 tactattaaa gttcttggtg gttctggacg taaaacagct aacattggtg atgtaattgt 140161 ttgcacggtt aaacaagcaa caccaggagg cgttgtcaaa aaaggtgaag tcgtaaaagc 140221 tgttatcgtt cgcactaaaa gcggagcgcg cagaagtgac ggttcataca tcagcttcga 140281 tgagaatgca tgtgttatca tccgtgacga caagagccca cgcggaactc gtatcttcgg 140341 accagttgct cgtgaattgc gtgaaaacaa ctttatgaaa attgtttctc tagctccaga 140401 agttatctaa ttgaaataaa tgccttactc aaggaggtgc gatcaggatg catgtaaaaa 140461 aaggcgataa agttatggtt atctctggta aagataaagg caaacaagga acaatccttg 140521 ctgctttccc taaaaaggac cgcgttttag ttgaaggtgt taacatggta aagaaacact 140581 ctaaaccaac tcaagctaac cctcaaggcg gtatttctaa tcaagaggcg ccaattcatg 140641 tatcaaacgt tatgccgctc gatcctaaaa caggtgaagt gactcgcgta ggatacaaag 140701 tggaagatgg caaaaaagtt cgtgtagcaa aaaaatctgg gcaagttcta gataaatagt 140761 attaaaagga agggaggtct atctcatgaa ccgccttaaa gaaaagtaca ataaagaaat 140821 tgcacctgct ttaatgacta agttcaacta tgattcagtc atgcaagtgc ctaaaatcga 140881 aaaaatcgta atcaacatgg gtgttggtga cgctgttcaa aacgccaaag caatcgacag 140941 tgctgttgag gaattaacgt ttatcgcagg tcaaaaacct gtcgttactc gtgcgaagaa 141001 atcaattgct ggattccgtc ttcgtgaggg aatgcctatc ggtgcgaaag taactcttcg 141061 cggagagcgc atgtatgatt tccttgataa acttatttct gtatctttac cgcgtgtacg 141121 tgacttccgc ggggtttcta aaaaatcttt cgacggtcgc ggtaactaca cacttggtat 141181 caaagaacag ttaatcttcc ctgaaattga ctacgataaa gtaacaaagg ttcgcggaat 141241 ggacatcgtt atcgtaacaa ctgctaatac tgacgaagaa gctcgtgagc tattaactca 141301 agtaggtatg ccgttccaga aataatcaat gaaagggagg cgaaatcgtg gctaaaaagt 141361 ctatgattgc gaaacaacaa cgtacaccaa agtttaaagt acaagagtac acacgctgtg 141421 aacgctgcgg acgtccgcat tcagtcattc gtaaatttaa actttgccgt atttgtttcc 141481 gtgagcttgc atataaagga caaattcctg gcgtgaaaaa agccagctgg taatccccaa 141541 gaaagggaag gaggtaatta tataatggtt atgacagatc caattgcaga tatgctaact 141601 cgtattcgca atgcaaacat ggtacgtcat gagaagcttg aaattcctgc ttctaaattg 141661 aaaagagaaa ttgctgaaat tttaaagcgt gaaggtttca ttcgtgacgt tgagttcgta 141721 gaagacagca aacaaggtat tatccgcgtt ttcttgaaat acggacaaaa caacgagcgc 141781 gttatcactg gtcttaaaag aatcagcaag cctggtttgc gtgtttatgc taaatctaat 141841 gaagtacccc gcgtacttaa cggtcttgga atcgcgatta tttctacatc acaaggtgtt 141901 ttaacggaca aagaagcccg tgcaaaacaa gctggtggag aagttctagc atacgtttgg 141961 taagaagttt aacatgaatg gaggtgtttg gtatgtctcg tgtaggtaag aagctacttg 142021 agattccttc tgatgttaca gtaacgttaa atgataacaa cactgtagct gtgaaaggac 142081 caaaaggaga attaactcgt acgtttcacc ctgatatgga gattaaagta gaggacaatg 142141 tgcttacagt cgctcgtcct tctgatcaaa aagagcaccg tgccctgcat ggtacgactc 142201 gcagtctgct tggcaacatg gttgaaggtg tatctaaagg atttgaaaga ggtttggaat 142261 tagtcggtgt cggttaccgt gcttctaaat ccggaaataa acttgtttta aacgttggat 142321 actctcatcc tgttgagatc gttcctgaag aaggcatcga aatcgaagtt ccttctcaaa 142381 caaaagtagt tgtaaaaggt acagacaaag aacgcgtagg agctattgct gctaacatcc 142441 gcgctgtacg ttctccagag ccttacaaag gtaaaggaat ccgctacgaa ggtgaagttg 142501 ttcgccgtaa agaaggtaaa tctgctaagt aagatcgctt aaagtgaaga aaggagtgac 142561 ctagatgatt acgaaaacta gcaaaaatgc tgctcgtctt aaaagacacg ctcgtgttcg 142621 cgctaaactt tccggtactg ctgaaagacc gcgcctgaac gttttccgtt ctaacaagca 142681 catttacgct caaatcatcg atgatgtaaa tggtgtaaca cttgctagtg catctactct 142741 cgataaagac ttgaacgttg aaagcactgg agatacttct gctgctacta aagttggaga 142801 attagttgca aaacgcgctg ctgaaaaagg catttctgac gtagtatttg accgtggcgg 142861 atacttatac catggacgtg taaaagcttt ggctgatgcc gctcgtgaag ctggacttaa 142921 attttaataa aagaaggagg gacacatgat tatgcgtcgt attgacccaa gcaaattaga 142981 gttagaagaa cgcttagtta cggttaaccg cgtagcgaaa gttgttaaag gtggtcgtcg 143041 tttccgcttc gcagctctag tcgttgtcgg tgacaaaaac ggacacgtag gattcggtac 143101 tggtaaagca caagaagtac cagaagcgat tcgcaaagct gttgaagatg cgaaaaagaa 143161 tttgattgaa gtaccaatgg ttggaactac aattccacac gaaatcatcg gacgtttcgg 143221 tgcaggtaac atcttgttaa aacctgcttc tgaaggtact ggagttatcg ctggaggccc 143281 tgtacgtgcg gtacttgagc tagctggtgt agctgatatc ctttctaagt ctttaggttc 143341 taacacaccg atcaacatga ttcgtgcaac acttcaaggt ttaagtgaac ttaaacgtgc 143401 tgaagacgtt gcgaagcttc gtggaaaatc tgtagaagaa ctgttaggat aaggagggaa 143461 cattaatggc taaattagaa attaccctca aacgaagtgt aatcggtcgc ccggaagacc 143521 aacgcgttac tgtaagaaca cttggtttaa agaaaacaaa ccaaactgtt gttcatgaag 143581 acaacgctgc gatccgtggt atgattaata aagtatctca tttagtttct gttaaagaac 143641 aataaaaata tttgatcgga taaggaggtg tcctaatgaa acttcatgaa ttaaaacctt 143701 cagaaggttc acgcaaaacg cgtaatcgcg taggtcgtgg tattggttct ggcaacggta 143761 aaacagctgg taaaggtcac aaaggtcaaa acgctcgttc tggcggcggt gtacgccctg 143821 gattcgaggg gggacaaatg cctttattcc aacgtcttcc taaacgtggt ttcactaaca 143881 tcaaccgcaa ggaatacgct gtagtcaacc tagacaaatt gaacggtttt gcagaaggaa 143941 cggaagtcac tcctgaactt cttctagaga ctggtgttat tagcaaactt aatgcaggag 144001 taaagattct tggcaacggt aaattagaga aaaaattaac tgtaaaagcc aataaattct 144061 ctgcttctgc gaaagaagct gttgaagctg ctggcggtac agctgaggtg atctaacttg 144121 tttaaaacaa tctccaactt tatgcgtgtg agtgatatca ggaataaaat catattcact 144181 ttactcatgc ttatcgtctt tcgcataggt gcgtttattc ctgtgcctta cgttaacgct 144241 gaagcgttac aggcacagtc tcaaatgggt gtttttgatc tccttaatac atttggcggc 144301 ggtgcgcttt accaattttc cattttcgca atgggaatta ctccttatat cacggcttcg 144361 atcatcattc agctgcttca gatggatgtg gtaccgaagt ttaccgagtg gtctaagcaa 144421 ggtgaagttg gccgccgtaa attagctcag ttcacaaggt actttacgat tgtgcttggt 144481 ttcatccaag cgttaggtat gtcatatgga ttcaacaatc tggcaaacgg tatgctgatc 144541 gaaaaatccg gtgtatcgac atatcttatc attgctttag tgctcactgg cggaactgcc 144601 tttttaatgt ggcttgggga acaaattact tctcatggag taggcaacgg aatatcgatc 144661 attatcttcg cggggattgt gtctagtatt ccaaaaacaa ttgggcaaat atatgagact 144721 caatttgtcg gcagcaacga tcagttgttt attcatattg tgaaagtcgc acttcttgtg 144781 attgcgattt tagcagttat tgttggagtt attttcattc agcaagccgt acggaaaatt 144841 gcgattcaat atgctaaagg cacaggtcgt tcacctgctg gcggaggtca gtctacacac 144901 cttccattga aagtgaatcc tgcaggggtt attccggtaa tctttgcggt tgcgtttttg 144961 ataacgccgc ggacgatcgc gtcattcttt ggaacaaacg atgtgacaaa gtggattcaa 145021 aacaactttg ataatacgca tccggtgggt atggcgatat atgttgcgtt gattattgcc 145081 tttacgtact tttatgcttt tgtacaggta aaccctgaac aaatggctga taaccttaaa 145141 aaacagggtg gctatatccc gggggttcgt ccagggaaaa tgactcaaga tagaattacg 145201 agcattttgt atcgacttac gtttgtgggt tctatattct tagccgtgat ttccattctt 145261 cctatctttt tcattcaatt cgctggattg cctcaaagtg cacaaattgg cggaacatct 145321 ttgttaattg ttgtcggggt agccttggag acaatgaaac aactagaaag ccagttggtg 145381 aaacgaaact accgtggatt tatgaaaaac tagaggaaat ggatttatcc attccctctt 145441 aataaagaga ggacggggga aatccgaatg aacttagtct taatggggct tcctggtgcc 145501 ggtaaaggca cacagggcga acgaattgtt gaggattatg ggattcctca tatctcaaca 145561 ggagatatgt tccgtgctgc tatgaaagaa gaaacaccac tcggactcga agcaaaatct 145621 tatattgata agggagagct cgtacctgac gaagtcacaa tcggaattgt aaaagagaga 145681 cttggcaaag atgattgtga aagaggtttt cttctggacg gatttccgcg aacagtcgct 145741 caagccgaag ctcttgaaga aattcttgag gaatacggca agccgattga ttatgtcatt 145801 aacattgaag tcgacaaaga tgttctgatg gaacgtctga ctggacgcag aatttgcagt 145861 gtttgcggca caacctatca tttagtcttt aatccgccga aaacgccggg tatttgtgat 145921 aaagacggag gcgaactcta tcaacgggca gatgataatg aggaaacagt ctctaaacgg 145981 cttgaggtaa acatgaagca aactcagcct ttactcgatt tctattcaga gaaaggttat 146041 cttgcaaacg tgaatggcca gcaggacatt caagacgttt atgcagatgt gaaggatctt 146101 cttggaggat taaaaaaatg attatctgta aaaccccacg tgaacttggt atcatgcggg 146161 aagcagggcg aatcgtggct ttaactcatg aagagttaaa aaagcacatt aaaccaggaa 146221 tctcgacaaa agaattggat caaattgccg aacgttttat taagaagcag ggtgcaatcc 146281 catcttttaa ggggtataat gggtttcgcg ggagcatttg cgtatcagtt aatgaagaac 146341 tcgttcacgg catacctggc agcagggtgc tgaaggacgg tgacatcatc agtattgata 146401 tcggtgctaa attaaatggt tatcatggtg actctgcatg gacatatccg gtaggaaaca 146461 tcagcgatga tgacaaaaaa cttctggaag tgacagagga gtctttatat aaaggcttgc 146521 aggaagcaaa accaggtgaa cgtttgtcga atatttccca cgcaatacaa acgtatgtcg 146581 aaaatgagca gttttcagtt gttagggagt atgtcggaca tggtgttggt caagacttgc 146641 atgaggaccc gcaaattcct cattacggtc cgcccaacaa aggaccacgg cttaaacctg 146701 gcatggttct cgctattgaa cctatggtga acgctggcag ccgctacgtg aaaacattgg 146761 ctgataactg gacggttgta acggtagatg ggaaaaagtg tgctcatttt gaacatacga 146821 ttgcgattac ggaaacgggt tttgatatac tgacgagagt ctagatgatg aaaataattc 146881 cgaagacaga tgtttttcaa gcttgatagg gcagaaagct tgggtgaaca ttggcaagac 146941 cgaattcatc ttgcttcttg tcgttggaat tttaaccatc atcaatgtac taacagcaga 147001 cggagaaaag cgtacatttc attctcctaa gaaaaagaat atcaatcatt taacccttta 147061 tgattgcgta tctccggaag ttcagaacag tataaacgaa acagggcgtg tgacaaactt 147121 cttttgaaat ttgtcagaaa gcaagttact gatttgaaga agggagaaca cttgaatggc 147181 gaaagacgat gtaattgaag tggaaggtac tatagtcgaa acactgccaa acgcgatgtt 147241 caaagttgaa cttgaaaatg gccacactgt tttggctcat gtatctggta aaatccgcat 147301 gcacttcatt cgcattttac ctggagacaa agttacggta gaattatctc catatgactt 147361 aactcgtggc aggattacgt accgttacaa ataaagcact ccggaaactg aaggaggttg 147421 gaaacacatg aaagtgagac catcagttaa accaatctgc gaaaaatgta aagttattcg 147481 cagaaaagga aaagtaatgg tgatctgtga aaatccaaag cataaacaaa aacaaggata 147541 atttataagg aggtgcccag agaatggctc gtattgctgg tgtagatatc ccacgtgaca 147601 aacgtgttgt tatttcttta acatacatct tcggaattgg ccgcacaacg gctcagcaag 147661 ttttaaaaga agctggagtt tcagaagata ctcgtgtgcg cgatcttact gaagaagaac 147721 ttggtaaaat ccgtgatatt attgacaaac tgaaagtaga aggtgacctt cgccgtgaag 147781 tttctcttaa tatcaaacgt ctgatcgaaa tcggaagcta ccgcggaatc cgtcatcgca 147841 gaggattacc tgttcgcgga caaaactcta aaaacaacgc gcgtactcgt aaaggtccgc 147901 gtcgtactgt agctaacaag aaaaaataag taagggaggt tcttaaacaa tggctgctgc 147961 tcgtaaatct aacacgcgta aacgtcgcgt gaaaaagaat attgagtctg gaattgctca 148021 tattcgttca actttcaata acacgatcgt tacgatcact gacactcatg gtaatgctat 148081 ttcttggtct agtgccggag ctttaggatt cagaggttct cgtaaatcta ctccttttgc 148141 tgcgcaaatg gctgcagaaa cagctgctaa aggttcaatc gaacatggtc ttaaaactct 148201 agaggttact gttaaaggac ctggttcagg ccgtgaagct gcaatccgtg cacttcaagc 148261 tgctggacta gaagtcactg ctatcagaga cgtaactcct gttcctcata acggatgccg 148321 tccaccaaaa cgtcgccgcg tgtaatttgt ttgtatagat tttgtgtccc tgtcaataat 148381 gggttatgat acagttattt atgaaacgaa tgcaccgact cgttgcctga gcacatacgg 148441 gactaaacaa tggggaattt cggatggaat ctcatatgat tctattcgag gtttcgacgt 148501 tttgaaggag ggttttaagt aatgatcgag attgaaaaac caaaaatcga aacggttgaa 148561 atcagcgacg atgccaaatt tggtaagttt gtcgtagagc cacttgagcg tggatatggt 148621 acaactctgg gtaactcctt acgtcgtatc ctcttatcct cactccctgg tgccgctgta 148681 acatcaatcc agatagatgg tgtactgcac gaattctcga caattgaagg cgttgtggaa 148741 gatgttacaa cgattatctt acacattaaa aagcttgcat tgaaaatcta ctctgatgaa 148801 gagaagacgc tagaaattga tgtacagggt gaaggaactg taacggcagc tgatattaca 148861 cacgatagtg atgtagagat cttaaatcct gatcttcata tcgcgactct tggtgagaat 148921 gcgagtttcc gagttcgcct tactgctcaa agaggacgtg ggtatacgcc tgctgacgca 148981 aacaagagag acgatcagcc aatcggcgtg attccgatcg attctatcta tacgccagtt 149041 tctcgtgtat cttatcaggt agagaacact cgtgtaggcc aagttgcaaa ctatgataaa 149101 cttacacttg atgtttggac tgatggaagc actggaccga aagaagcaat tgcgcttggt 149161 tcaaagattt taactgaaca ccttaatata ttcgttggtt taactgacga agctcaacat 149221 gctgaaatca tggttgaaaa agaagaagat caaaaagaga aagttcttga aatgacaatt 149281 gaagaattgg atctttctgt tcgttcttac aactgcttaa agcgtgcggg tattaacacg 149341 gttcaagagc ttgcgaacaa gacggaagaa gatatgatga aagttcgaaa tctaggacgc 149401 aaatcacttg aagaagtgaa agcgaaacta gaagaacttg gactcggact tcgcaaagac 149461 gattgactag tttcccttgt gaactaggat tttcgtgtgt ttattattca gaaacagcat 149521 tccaataaag gaggggacat cacatgtcat acagaaaact aggacgtacg agtgcacagc 149581 gtaaagctat gcttcgtgat cttacaactg atttgatcat caacgaaaga atcgaaacaa 149641 ctgaaacacg tgcgaaagaa cttcgctctg tagttgaaaa aatgatcacg cttggcaaac 149701 gcggtgatct tcacgctcgc cgtcaagctg ctgcatacat ccgcaacgag gttgcaaacg 149761 aagaaaataa tcaagatgca cttcaaaaat tattctctga cattgcaact cgttacgagg 149821 agcgccaagg tggatacaca cgtattatga agcttggtcc tcgccgtggt gacggagcac 149881 caatggcaat tatcgaattg gtttaatcac atatttttgt gtatctaaag aagggcggga 149941 cagtttctaa ctggatctat gccctttttt tagatactgc aacttttaat agagagaaaa 150001 gcagagcatt agctgagagg aggccggttt tccatgaatc aaaatcagtt gatatcggta 150061 gaggatatcg tatttcgata tcggaaggac gcagaaagac gagcactaga cggcgtctcc 150121 ctgcaggtgt atgagggtga atggcttgca atcgtaggtc ataacggttc agggaaatca 150181 acactggccc gggcattgaa tggtttaatt cttcctgaat caggcgacat tgaggttgcc 150241 gggattcaat tgacagagga atctgtttgg gaagtgcgta agaagatagg tatggtcttt 150301 caaaatccgg ataaccaatt tgtcggaacg actgttcgcg atgatgtggc ttttggttta 150361 gaaaacaatg gtgtaccgcg ggaagaaatg attgagagag tagactgggc agtaaaacag 150421 gtgaatatgc aagattttct cgatcaagag ccgcaccatc tctccggagg ccaaaagcag 150481 agagttgcga ttgcgggggt tattgccgca cgtcctgata ttattatctt agatgaagca 150541 acatccatgc ttgatccgat cgggcgagaa gaagtgcttg aaacggtaag acatttaaaa 150601 gagcagggca tggcgactgt catatccatt acacatgacc tgaatgaggc agcaaaagca 150661 gacaggatca ttgtcatgaa tggcggtaaa aaatatgctg aagggccgcc tgaagagatt 150721 tttaaattga ataaagaact tgttcgaatt gggcttgatt tacccttctc attccagctt 150781 agccagcttt taagagaaaa tggactggct ttggaagaaa accatttgac tcaggaaggg 150841 ctggtgaaag agctgtggac attacaatca aagatgtaga gcatcgctat cagatgaaga 150901 ccccgtttga gcgcctagca ctgtatgata tcaatgcatc gattaaagaa ggaagctacg 150961 tagccgttat cgggcataca ggctctggca agtccactct tctacagcac ctaaatggtc 151021 tcctgaagcc gacgaaggga cagatatcac taggcagcac tgtcattcag gcagggaaaa 151081 agaataaaga tctgaaaaaa cttcgtaaaa aagtcggaat cgttttccaa tttcctgagc 151141 atcaattatt cgaagaaaca gttcttaaag atatttcatt cggaccgatg aactttggtg 151201 ttaaaaaaga agatgctgaa caaaaagcga gagagatgct gcagcttgta ggtttatcag 151261 aagagctttt ggacaggtca ccctttgaat taagcggggg acaaatgcgc agagttgcaa 151321 ttgccggcgt acttgcaatg gaccctgaag tgcttgttct ggatgaaccg actgcaggat 151381 tggacccaag agggcgaaaa gagattatgg acatgtttta tgagcttcat caacgtggga 151441 acttgacgac gatccttgtg acacacagca tggaggatgc agctgcatac gctgatgaaa 151501 tgattgttat gcataaagga acgatacaag catcaggcag tccgcgtgat ctgtttttaa 151561 agggtgaaga gatggccggc tgggggctgg atcttcctga aacaataaaa ttccaaagac 151621 accttgaagc tgcactgggt gtgagattta atgagcctat gctcacaatc gaagatgccg 151681 ctgccgaaat ccgtgctctt tttcagggag agaagacttt atgatggaca gcatgattat 151741 cggcaagtat gtaccgggga cttcacttgt gcaccggctt gaccccagaa caaaactgat 151801 cacgatcttt ttatttgtct gcattgtatt cttagccaat aatgttcaga catatgcgtt 151861 gcttggttta tttacaattg gcgtcgtttc tttaacaaga gttcctttct cttttttaat 151921 gaaagggctg aagccaatca tctggattgt cctttttacg ttccttcttc acattcttat 151981 gacacatgaa ggaccgatta tctttcaaat aggttttttc aaagtctatg agggcggtct 152041 ggttcagggg atattcattt ctcttagatt cgtctatttg attttaatca caaccttatt 152101 aacgcttacg actacaccga ttgagattac cgatggaatg gagcagctgc tgaacccatt 152161 gaaaaaatta aagcttcctg ttcatgagct ggctcttatg atgtcaattt ctttacggtt 152221 tattccgaca ctgatggagg agacagataa gatcatgaag gctcagatgg cgcgaggcgt 152281 tgattttaca agcgggcctg tcaaagaaag agtgaaggct attgtcccgc ttcttgtccc 152341 gctcttcgtc agcgcattta aacgcgccga agagcttgcg gtggcaatgg aagcaagagg 152401 ctatcaaggc ggagaaggac gtacgaaata tagaaagctt gtatggacag gaaaagacac 152461 ttctgtcatt gtcagcttaa ttgtattagc tgctttgtta tttttcttaa gggcttagag 152521 gtgctgtatg agactgaaat gcacgatttc ttatgacgga catttgttta acggttatca 152581 ggttcagccg ggcaaaagaa cggttcagga tgaactggag aaggctttgg ctgtcctgca 152641 taagtcaaaa gacagaattc cggtcgtttc gtctggaaga acagacagcg gggttcacgc 152701 agccggacag gtgattcatt ttgacactcc gctgtctatc ccggctgaga gatggccata 152761 tgccttaaat gcactgcttc cggacgatat cgcagtcaaa caggcagaaa ttgcggatga 152821 tgggttccat gcacgattta gcgcagtcaa aaaagaatat cgctactttg tatacacgga 152881 gaaacacccg gacgtattta aacggcatta cgcttaccat ttttcatatc gccttaatgt 152941 gcaggacatg agagaagcgg caaagcatct tatagggaca catgatttta cgagcttttg 153001 cgcggctaaa acagaagtgc aggacaaggt aagaacgata tacgaacttg attggactga 153061 gacggctgac ggcctgcaaa tgcggatcac aggcagcggt ttcttatata atatggtcag 153121 aattattgcg ggtactttgc ttgatgcagg tattggaaaa atttctcccg atgaggtgaa 153181 atccatgctg gaagcgaagg atcgcgaagc ggcagggcgc acagcgccgg ggcacgggct 153241 atatttatgg aacgtttact atgacaacta aaccaggtgt ataatatttt cttgacagag 153301 tctgcataaa gttataagat atcatatggt atgtatttca accccacgat aagccccgga 153361 acttattgtg ttgtgaaata gaacgtaatc gaagtttatt gaaaatgaca gatcatttag 153421 gagggaaatt caatgcgtac aacacctatg gctaacgcaa gtactattga acgcaagtgg 153481 ttagttgttg atgctgctgg caagacttta ggtcgtcttt cttcagaagt tgcagctatc 153541 cttcgcggaa aacacaaacc aacttacaca ccacacgttg atactggaga tcatgtgatc 153601 atcatcaacg ctgaaaaaat cgagttaact ggtaaaaagt taactgacaa aatctactac 153661 cgtcacactc aacatccagg cggattaaaa tcaagaactg ctcttgaaat gcgtacaaac 153721 taccctgaga aaatgcttga gcttgctatc aaaggcatgc ttccaaaagg ttctctaggt 153781 cgtcaaatgt tcaaaaaatt gaacgtatac cgtggttctg agcatccaca cgaagcacaa 153841 aaacctgaag tttacgaact tcgcggttaa ttaaaaagga ggttaccaat ttggcacagg 153901 ttcaatatta cggtactggc cgtcgtaaaa gctctgtagc gcgtgtgcgt ttagttccag 153961 gagaaggccg tatcgtcgtt aataatcgtg aaatcagcga acatatccca tctgcagctt 154021 taatcgaaga tatcaaacaa ccattaactt tgactgaaac agctggcact tatgatgttt 154081 tagtaaacgt acatggaggc ggcctatctg gtcaagctgg agcaatccgt cacggtatcg 154141 ctcgtgcttt gcttgaagca gatccagaat accgtacaac tcttaaacgt gcaggtcttc 154201 tgactcgtga cgctcgtatg aaagaacgta aaaaatacgg tcttaaaggc gctcgtcgtg 154261 cacctcagtt ctcaaaacgt taattttacg ttttcaaaaa gctctcgacc ttgggttggg 154321 agcttttttc tttcaataaa acgtggcagt cccgcataaa aataacaact gaatggacgc 154381 ttgacggggt taagcaaatt gtttgtttat aaacggtctc tttgtaataa tcatggtaga 154441 tttcattctt attcaattgg aagttcggtc aatgtttatt atcgttatgt gatcagccca 154501 gctccatcta accactgtat ctcatccgtt aaagttcact gctgattctt aacccggaga 154561 aacaatagct ctcattgcta atggctttat gtaacgaagt aaaagtaaat ctgatgatat 154621 aaatcacata tctcctttgt gatttttttg cgtttttatg aacttttttc taaatatgca 154681 aagggaaagc gatatcaatc tagaaatatt tgttatactc tatacattaa agtaaggaga 154741 agattcatga atgcgttagt agctcataat agcaaagcct gggataaaaa agtagaaaca 154801 ggcaatgaat ggactgttgc tgttgaacag caggttatcg aacaagcaaa aaaaggcaat 154861 tgggatataa gggtaacacc aatgaaagat gtaccgaagg attggtttcc gcctatcaaa 154921 ggtctgaaag tactctgttt agcatcaggc ggcggccagc agggtccagt tttggcagcc 154981 gcaggcgcgg atgtcactgt attagataac tcagaaaaac agctgaatca ggatagaatg 155041 attgctgagc gagatggtct gacgatacac actgtcaaag gaagcatgga cgatttaagt 155101 gtatttaatg atgaatcatt tgatgtcatt gtacatcctg ttgccaatgt ttttgttgag 155161 aatgtcctcc cggtatggaa ggaagcgtac cgtgtgttga aaaggaacgg cattctaatc 155221 tcgggttttg tcaatcctgt tgtatttctg tttgatacag aattagaaca gcaaggtgtt 155281 ttaaaagtaa aacactctat tccatacgct gacccagaag atcttccgaa acataaagtg 155341 aaaaaactga tcgaaaataa tgaggctctg gaattcggcc attccttaga agaccaaatc 155401 aaaggccaaa ttgatgccgg ttttatcgtt actggttttt atgaagataa aggcggtttt 155461 gtattagacc aatatatcca tacatattct gcaacaagaa gcgtgaaagt atgaaaagca 155521 gcgacctgtt agaggggctg cttttttcat aaccaattac agaacatttg ttcctcaccc 155581 tgcagaaagc tgatttttta tcaatgttac accttcattt gggcgaattt ccaaccgaat 155641 tcgggcattg tttcatcatc caaacctcaa aataatcggt aaaaggagag tgaatttata 155701 tggcagaagt actgtctttt atggatgtga aacgccaaaa ggattttgaa ttagaaaaga 155761 acttgctcaa agaactctct ctgagacaaa ttatccagtc tgttaaggat tgtttggaac 155821 cattatttcc atttttacat gatgaacgag atattattac cgaaggctgt attgattttg 155881 cgattgaagc ttatttgtta ggcgggcgtt ttgggatatt cggctattac ggagaatcaa 155941 tgcagagtat cagtgcccgc tctgcaagag aagaagaaga gctgcgtatg gagttttttg 156001 attatctcta taattggata cacgagcaat acgcaacatt tgataaaaac actgtttatg 156061 aagcggcacg caagttcatt aaagattggt ggacagcagg gtttgttcaa agagaaaaac 156121 agtgtaagct tcgcatgcgg taatcatatt tcccgaccct gtcccatagt tatgtaataa 156181 cggacaagcg ggaggggaag ggatgaggaa aaagcttaaa tggctcagtt ttttgctagg 156241 cttcatcata ttactatttc tgttcaagta tcagttcagc aataacgact cttggaagcc 156301 gtggagcctg cccttgagcg gtaaaatcat ttatctagat ccaggtcatg gcgggcctga 156361 cggcggagca gtcggcggaa agctgttaga gaaggatgtt accctggaag tggcctttag 156421 agtcagggat tatcttcaag aacaaggagc gcttgttatc atgaccagag aaagtgatac 156481 tgatctcgct ccagaaggaa caaaaggcta tagccgacga aaagctgagg atctaagaca 156541 acgagtcaaa ttaataaacc attcagaggc ggagctctat atcagcattc atcttaatgc 156601 gattccgtca caaaaatgga gcggagccca aagcttttat tacgggaaat atgcggaaaa 156661 tgagaaagtc gcaaaataca ttcaggatga gctgagaaga aatctggaaa acacaacccg 156721 gaaagcaaag cggattcatg gtatctactt aatgcaaaac gtcaccaaac cgggggcgct 156781 tatagaagtc ggatttttat ccaatccaag tgaagcaacg ttgctcggta aaccgaaata 156841 tcaagacaag gtggcatctt ccatatataa aggcattttg cgatatttca cagaaaaagg 156901 agaccctccg gagtaatgga gggttttctt gtggttctaa gcataagaca cccgccattt 156961 atgtatgata taataataat tgtaaacgaa tacacaaaag ggtgaggttc gatgataaga 157021 gaagatgaag taagaaaact agtcggagaa atgcgcgaac cttttcttca aagacctctg 157081 ggagaattgg atgccgttaa ggaaattaaa ataaagcctg aaaaacggca tatcagtgta 157141 aaagtcgctc ttgcaaaaac aggaactgca gaacaaatgc agattcagca agagatcgta 157201 aacgtattaa aaggggcagg agctgagaca gtcggccttc gatttgaaga gctgcctgaa 157261 gaaacggttg ctaaattccg ggcgccgtca gctgagaaaa aaacattatt aaatatggat 157321 aacccgccag tctttcttgc tgtagcaagt ggaaaaggcg gcgtaggcaa gtcaactgtg 157381 tcagtaaacc tagctatttc tctggctcgt ctagggaaaa aggttggttt aattgatgcg 157441 gatatttatg ggttcagtgt gccggacatg atgggtatca ctgtgcgtcc aacaattgaa 157501 ggagagaaac ttcttcctgt tgaacgcttt ggagtaaagg tcatgtcaat gggctttttc 157561 gtagaagaaa atgccccggt cgtatggaga gggccgatgc tcggcaaaat gctgaataat 157621 tttttccatg aagtagagtg gggagaagta gactatatcg ttcttgatct tccgcctggt 157681 acaggggacg ttgctctcga tgtacataca atgcttccga gctgcaaaga aattatcgta 157741 tctacgccac atccgacagc tgcttttgtc gcggccagag cgggctctat ggcgattaaa 157801 accgatcatg aggtcgtggg tgtcatagag aacatggctt attatgaaag tgcaaagaca 157861 ggggaaagag aatatgtgtt tggaaaaggc ggaggagata aactggctga ggaactaaac 157921 gtgcctttgc tcggcagaat cccattgaaa cagcccgatt gggataagga ccaatttgct 157981 ccgtctgttt atgacgaaaa tcatccaatc ggagaaatat atcaggacat cgcaaaaaaa 158041 atagatgcaa aaatgtcagt gcaggtataa aaggtgaacc gggattccag atcccggctt 158101 tccctttatt cactttcttt tgctgtgtct tttgctgctt ttttcagctc atcttcgaac 158161 tgctttttgt aaagcggact agaaagtgtt tcgttaataa cctcttctaa ataactgcgg 158221 aattcttggc tttttgccag ctggctgtac tttttatcca tgccgggatc ctgcataacg 158281 ctcatcagca tcttctggta atctggatcc ttcatcagct ttttaatcac tttttcatgc 158341 tctgtctgaa gagttttggc aaagccctca gcaaaatcag tgtcttcaaa gatgtttttc 158401 caaaattctt cacctttttt agatgtgagt gttttttcta ttgttccttt aattgcatct 158461 tggtcaatca ccagcgcttc attcatggca tcatcattta ataattcctt aatagctttc 158521 tttccatcat cagtttttaa tatatcaaca accatttttt tggtctgatc atagtccata 158581 tccgctgctt ggtcttttgg agcgcaagct gttacagata ataacaaaaa acagctcatc 158641 aatagcgttt tggcttttga catgcttaag ctcctttcac atacttgtct tacctttaat 158701 atgattcatc tgtttggaat tatacataac aaaatatcgc tgttcgcgat ttttgagggg 158761 atgaataaag aaatgaaaag ccgtggttta gttcgttttt tcttttctat tttagctgtc 158821 ggggcgctta tcacgagtat tgtgggtttt gctttaaagt ggggagaata tagagggctg 158881 tttctaacat ttgaagcggg acagattttc tctgttttat tttggtttat cggtgtaggc 158941 atgattttca gtgtgatcag ccaaatgggt tttttcgtgt ttttaacagt tcatcggttt 159001 gcgcttgaga tattaaggtc ctcctctttg tggaatttgc tgcagttgtt tttcatcctg 159061 tttgttgctt ttgatttaat gtacgtgcgt tttttatttt ttggagagag cggagaatcg 159121 ctggctggct atgcgtggtt accggtgttt ttattgatct ttggagtgat tacagcttat 159181 ataaagcaaa agcagtcctc taagaaaaca tttgtgtcat cgttattttt gatggttgtg 159241 attaccgcat tagaatggtt ccctgcatta agagtaaatg atgaggactg gctttattta 159301 atgctttttc cgttaatggc atgtaatgcc ttccaattgc tgatgctgcc gaagtttgca 159361 gcaaagtaat tactttacct ctgcggattt ggcatcagaa tttgcgatga gatcacccac 159421 ggttacattt tttaatcctt tttctttcag ctgatggatg atatcaggca atgcttcttc 159481 tgtttgtttt gcagaatcgg aggcatgtaa aagaataatg tctccaccgg aaacttgctt 159541 ggtcacattg tcgatgattt tttcaactcc gggatttgtc cagtcttgag agttcacact 159601 gtaatgaacg actgtataat tgtattgctt tgcgaccttt agaacattct tattgaattg 159661 gccggtaggg ggtcttaata gctgtatgtc tttgacccct aacttttcaa aggctgtttg 159721 cgcacggttc atgtcctttt ttatttcgct gctctctaaa ttggcatagt ttttataagc 159781 gtagcccatg ctcccgattt gatggccgtc ctttacgata cgggccactg tgtcgggatg 159841 gcgttctgcc caagaagcgg acaggaaaaa cgttgcgttt ttaatcccgt ttgctttcag 159901 agtattaagt atcggttctg ctctctcatc accccagctg atatcgaaag taagtgaaat 159961 atctttagag tctgtttctc ctttataaat ggctttaggt ccggtgtcag ttgaaaacac 160021 gggaagcggg acagctcttt ggatataaaa aaagctggca gctgcaaatg cggcgataag 160081 tataataatt aattgtttta cccgtttaat gtgccacaca tagaagtgat tcactgatga 160141 tgcctcctta tcttgtccat cattcttgtt ttacatctta tgagcatgga caattgaata 160201 taaccgataa aatgtctctt cacatacagc ctaaattggg tgttgacctt ttgataatat 160261 ccgtgatata ttattattcg tcgctgataa acagctgaca tcaactaaaa gcttcattaa 160321 atactttgaa aaaagttgtt gacttaaaag aagctaaatg ttatagtaat aaagctgctt 160381 cgttaagcgg cagtaatgat ctttgaaaac taaacaagac aaaacgtacc tgttaattca 160441 tttttataaa tcgcacagcg atgtgcgtag tcagtcaaac tactttatcg gagagtttga 160501 tcctggctca ggacgaacgc tggcggcgtg cctaatacat gcaagtcgag cggacagatg 160561 ggagcttgct ccctgatgtt agcggcggac gggtgagtaa cacgtgggta acctgcctgt 160621 aagactggga taactccggg aaaccggggc taataccgga tggttgtttg aaccgcatgg 160681 ttcaaacata aaaggtggct tcggctacca cttacagatg gacccgcggc gcattagcta 160741 gttggtgagg taatggctca ccaaggcaac gatgcgtagc cgacctgaga gggtgatcgg 160801 ccacactggg actgagacac ggcccagact cctacgggag gcagcagtag ggaatcttcc 160861 gcaatggacg aaagtctgac ggagcaacgc cgcgtgagtg atgaaggttt tcggatcgta 160921 aagctctgtt gttagggaag aacaagtacc gttcgaatag ggcggtacct tgacggtacc 160981 taaccagaaa gccacggcta actacgtgcc agcagccgcg gtaatacgta ggtggcaagc 161041 gttgtccgga attattgggc gtaaagggct cgcaggcggt ttcttaagtc tgatgtgaaa 161101 gcccccggct caaccgggga gggtcattgg aaactgggga acttgagtgc agaagaggag 161161 agtggaattc cacgtgtagc ggtgaaatgc gtagagatgt ggaggaacac cagtggcgaa 161221 ggcgactctc tggtctgtaa ctgacgctga ggagcgaaag cgtggggagc gaacaggatt 161281 agataccctg gtagtccacg ccgtaaacga tgagtgctaa gtgttagggg gtttccgccc 161341 cttagtgctg cagctaacgc attaagcact ccgcctgggg agtacggtcg caagactgaa 161401 actcaaagga attgacgggg gcccgcacaa gcggtggagc atgtggttta attcgaagca 161461 acgcgaagaa ccttaccagg tcttgacatc ctctgacaat cctagagata ggacgtcccc 161521 ttcgggggca gagtgacagg tggtgcatgg ttgtcgtcag ctcgtgtcgt gagatgttgg 161581 gttaagtccc gcaacgagcg caacccttga tcttagttgc cagcattcag ttgggcactc 161641 taaggtgact gccggtgaca aaccggagga aggtggggat gacgtcaaat catcatgccc 161701 cttatgacct gggctacaca cgtgctacaa tggacagaac aaagggcagc gaaaccgcga 161761 ggttaagcca atcccacaaa tctgttctca gttcggatcg cagtctgcaa ctcgactgcg 161821 tgaagctgga atcgctagta atcgcggatc agcatgccgc ggtgaatacg ttcccgggcc 161881 ttgtacacac cgcccgtcac accacgagag tttgtaacac ccgaagtcgg tgaggtaacc 161941 ttttaggagc cagccgccga aggtgggaca gatgattggg gtgaagtcgt aacaaggtag 162001 ccgtatcgga aggtgcggct ggatcacctc ctttctaagg atattatacg gaatataaga 162061 ccttgggtct tataaacaga acgttccctg tcttgtttag ttttgaagga tcattccttc 162121 gaaacgtgtt ctttgaaaac tagataacag tagacatcac attcaagtaa tacaagatat 162181 cacatagtga ttctttttaa cggttaagtt agaaagggcg cacggtggat gccttggcac 162241 taggagccga tgaaggacgg gacgaacacc gatatgcttc ggggagctgt aagcaagctt 162301 tgatccggag atttccgaat ggggaaaccc accactcgta atggagtggt atccatatct 162361 gaattcatag gatatgagaa ggcagacccg gggaactgaa acatctaagt acccggagga 162421 agagaaagca aatgcgattc cctgagtagc ggcgagcgaa acgggattag cccaaaccaa 162481 gaggcttgcc tcttggggtt gtaggacact ctgtacggag ttacaaagga acgaggtaga 162541 tgaagaggtc tggaaaggcc cgccatagga ggtaacagcc ctgtagtcaa aacttcgttc 162601 tctcctgagt ggatcctgag tacggcggaa cacgtgaaat tccgtcggaa tccgggagga 162661 ccatctccca aggctaaata ctccctagtg accgatagtg aaccagtacc gtgagggaaa 162721 ggtgaaaagc accccggaag gggagtgaaa gagatcctga aaccgtgtgc ctacaagtag 162781 tcagagcccg ttaacgggtg atggcgtgcc ttttgtagaa tgaaccggcg agttacgatc 162841 tcgtgcaagg ttaagcagaa gatgcggagc cgcagcgaaa gcgagtctga atagggcgca 162901 tgagtacgtg gtcgtagacc cgaaaccagg tgatctaccc atgtccaggg tgaagttcag 162961 gtaacactga atggaggccc gaacccacgc acgttgaaaa gtgcggggat gaggtgtggg 163021 taggggtgaa atgccaatcg aacctggaga tagctggttc tctccgaaat agctttaggg 163081 ctagcctcaa ggtaagagtc ttggaggtag agcactgatt ggactagggg cccctaccgg 163141 gttaccgaat tcagtcaaac tccgaatgcc aatgacttat ccttgggagt cagactgcga 163201 gtgataagat ccgtagtcga aagggaaaca gcccagaccg ccagctaagg tcccaaagta 163261 tacgttaagt ggaaaaggat gtggagttgc ttagacaacc aggatgttgg cttagaagca 163321 gccaccattt aaagagtgcg taatagctca ctggtcgagt gactctgcgc cgaaaatgta 163381 ccggggctaa acgtatcacc gaagctgcgg actgttcttc gaacagtggt aggagagcgt 163441 tctaagggct gtgaagccag accggaagga ctggtggagc gcttagaagt gagaatgccg 163501 gtatgagtag cgaaagaggg gtgagaatcc cctccaccga atgcctaagg tttcctgagg 163561 aaggctcgtc cgctcagggt tagtcgggac ctaagccgag gccgaaaggc gtaggcgatg 163621 gacaacaggt tgatattcct gtaccacctc ctcaccattt gagcaatggg gggacgcagg 163681 aggatagggt aagcgcggta ttggatatcc gcgtccaagc agttaggctg ggaaataggc 163741 aaatccgttt cccataaggc tgagctgtga tggcgagcga aatatagtag cgaagttcct 163801 gattccacac tgccaagaaa agcctctagc gaggtgagag gtgcccgtac cgcaaaccga 163861 cacaggtagg cgaggagaga atcctaaggt gatcgagaga actctcgtta aggaactcgg 163921 caaaatgacc ccgtaacttc gggagaaggg gtgctctgtt agggtgcaag cccgagagag 163981 ccgcagtgaa taggcccagg cgactgttta gcaaaaacac aggtctctgc gaagccgtaa 164041 ggcgaagtat aggggctgac gcctgcccgg tgctggaagg ttaagaggag cgcttagcgt 164101 aagcgaaggt gcgaattgaa gccccagtaa acggcggccg taactataac ggtcctaagg 164161 tagcgaaatt ccttgtcggg taagttccga cccgcacgaa aggcgcaacg atctgggcac 164221 tgtctcaacg agagactcgg tgaaattata gtacctgtga agatgcaggt tacccgcgac 164281 aggacggaaa gaccccgtgg agctttactg cagcctgata ttgaatgttg gtacagcttg 164341 tacaggatag gtaggagcct tggaaaccgg agcgccagct tcggtggagg catcggtggg 164401 atactaccct ggctgtattg accttctaac ccgccgccct tatcgggcgg ggagacagtg 164461 tcaggtgggc agtttgactg gggcggtcgc ctcctaaaag gtaacggagg cgcccaaagg 164521 ttccctcaga atggttggaa atcattcgca gagtgtaaag gcacaaggga gcttgactgc 164581 gagacctaca agtcgagcag ggacgaaagt cgggcttagt gatccggtgg ttccgcatgg 164641 aagggccatc gctcaacgga taaaagctac cccggggata acaggcttat ctcccccaag 164701 agtccacatc gacggggagg tttggcacct cgatgtcggc tcatcgcatc ctggggctgt 164761 agtcggtccc aagggttggg ctgttcgccc attaaagcgg tacgcgagct gggttcagaa 164821 cgtcgtgaga cagttcggtc cctatccgtc gcgggcgcag gaaatttgag aggagctgtc 164881 cttagtacga gaggaccggg atggacgcac cgctggtgta ccagttgttc tgccaagggc 164941 atcgctgggt agctatgtgc ggacgggata agtgctgaaa gcatctaagc atgaagcccc 165001 cctcaagatg agatttccca ttccgcaagg aagtaagatc cctgaaagat gatcaggttg 165061 ataggtctga ggtggaagtg tggcgacaca tggagctgac agatactaat cgatcgagga 165121 cttaaccata tttttgaatg atgtcacatc tgttatctag ttttgagaga acactctcaa 165181 tttgtttggt ggcgatagcg aagaggtcac acccgttccc ataccgaaca cggaagttaa 165241 gctcttcagc gccgatggta gtcgggggtt tccccctgtg agagtaggac gccgccaagc 165301 agatttatta attctaccat gtttgtttat gaagctttat attattccgc agtagctcag 165361 tggtagagct atcggctgtt aaccgatcgg tcgtaggttc gaatcctacc tgcggagcca 165421 ttgcttccat agctcagcag gtagagcact tccatggtaa ggaagaggtc agcggttcga 165481 gcccgcttgg aagcttaaat gtattattac caaggtttct cataaggaga aagctttttt 165541 tattgcgata tgcggaagta gttcagtggt agaacaccac cttgccaagg tgggggtcgc 165601 gggttcgaat cccgtcttcc gctccattta tcctaacggg atattgtaaa ttgaattgcg 165661 cccgtagctc aattggatag agcgtttgac tacggatcaa aaggttaggg gttcgactcc 165721 tctcgggcgc gccatatctt ttaatagaat agataggaaa tcgggaagta gctcagcttg 165781 gtagagcaca tggtttggga ccatggggtc gcaggttcga atcctgtctt cccgaccatt 165841 ttttatgggg ccttagctca gctgggagag cgcctgcttt gcacgcagga ggtcagcggt 165901 tcgatcccgc taggctccac caaaagtttt taaaaaagtt attgactttg aagaagtgac 165961 attgtatact aataaagttg ctttaacaaa gcggacaaac aaaatgatct ttgaaaacta 166021 aacaagacaa aacgtacctg ttaattcagt ttttaaaaat cgcacagcga tgtgcgtagt 166081 cagtcaaact actttatcgg agagtttgat cctggctcag gacgaacgct ggcggcgtgc 166141 ctaatacatg caagtcgagc ggacagatgg gagcttgctc cctgatgtta gcggcggacg 166201 ggtgagtaac acgtgggtaa cctgcctgta agactgggat aactccggga aaccggggct 166261 aataccggat ggttgtttga accgcatggt tcaaacataa aaggtggctt cggctaccac 166321 ttacagatgg acccgcggcg cattagctag ttggtgaggt aacggctcac caaggcaacg 166381 atgcgtagcc gacctgagag ggtgatcggc cacactggga ctgagacacg gcccagactc 166441 ctacgggagg cagcagtagg gaatcttccg caatggacga aagtctgacg gagcaacgcc 166501 gcgtgagtga tgaaggtttt cggatcgtaa agctctgttg ttagggaaga acaagtaccg 166561 ttcgaatagg gcggtacctt gacggtacct aaccagaaag ccacggctaa ctacgtgcca 166621 gcagccgcgg taatacgtag gtggcaagcg ttgtccggaa ttattgggcg taaagggctc 166681 gcaggcggtt tcttaagtct gatgtgaaag cccccggctc aaccggggag ggtcattgga 166741 aactggggaa cttgagtgca gaagaggaga gtggaattcc acgtgtagcg gtgaaatgcg 166801 tagagatgtg gaggaacacc agtggcgaag gcgactctct ggtctgtaac tgacgctgag 166861 gagcgaaagc gtggggagcg aacaggatta gataccctgg tagtccacgc cgtaaacgat 166921 gagtgctaag tgttaggggg tttccgcccc ttagtgctgc agctaacgca ttaagcactc 166981 cgcctgggga gtacggtcgc aagactgaaa ctcaaaggaa ttgacggggg cccgcacaag 167041 cggtggagca tgtggtttaa ttcgaagcaa cgcgaagaac cttaccaggt cttgacatcc 167101 tctgacaatc ctagagatag gacgtcccct tcgggggcag agtgacaggt ggtgcatggt 167161 tgtcgtcagc tcgtgtcgtg agatgttggg ttaagtcccg caacgagcgc aacccttgat 167221 cttagttgcc agcattcagt tgggcactct aaggtgactg ccggtgacaa accggaggaa 167281 ggtggggatg acgtcaaatc atcatgcccc ttatgacctg ggctacacac gtgctacaat 167341 ggacagaaca aagggcagcg aaaccgcgag gttaagccaa tcccacaaat ctgttctcag 167401 ttcggatcgc agtctgcaac tcgactgcgt gaagctggaa tcgctagtaa tcgcggatca 167461 gcatgccgcg gtgaatacgt tcccgggcct tgtacacacc gcccgtcaca ccacgagagt 167521 ttgtaacacc cgaagtcggt gaggtaacct tttaggagcc agccgccgaa ggtgggacag 167581 atgattgggg tgaagtcgta acaaggtagc cgtatcggaa ggtgcggctg gatcacctcc 167641 tttctaagga tattatacgg aatataagac cttgggtctt ataaacagaa cgttccctgt 167701 cttgtttagt tttgaaggat cattccttcg aaacgtgttc tttgaaaact agataacagt 167761 agacatcaca ttcaagtaat acaagatatc acatagtgat tctttttaac ggttaagtta 167821 gaaagggcgc acggtggatg ccttggcact aggagccgat gaaggacggg acgaacaccg 167881 atatgcttcg gggagctgta agcaagcttt gatccggaga tttccgaatg gggaaaccca 167941 ccactcgtaa tggagtggta tccatatctg aattcatagg atatgagaag gcagacccgg 168001 ggaactgaaa catctaagta cccggaggaa gagaaagcaa atgcgattcc ctgagtagcg 168061 gcgagcgaaa cgggattagc ccaaaccaag aggcttgcct cttggggttg taggacactc 168121 tgtacggagt tacaaaggaa cgaggtagat gaagaggtct ggaaaggccc gccataggag 168181 gtaacagccc tgtagtcaaa acttcgttct ctcctgagtg gatcctgagt acggcggaac 168241 acgtgaaatt ccgtcggaat ccgggaggac catctcccaa ggctaaatac tccctagtga 168301 ccgatagtga accagtaccg tgagggaaag gtgaaaagca ccccggaagg ggagtgaaag 168361 agatcctgaa accgtgtgcc tacaagtagt cagagcccgt taacgggtga tggcgtgcct 168421 tttgtagaat gaaccggcga gttacgatct cgtgcaaggt taagcagaag atgcggagcc 168481 gcagcgaaag cgagtctgaa tagggcgcat gagtacgtgg tcgtagaccc gaaaccaggt 168541 gatctaccca tgtccagggt gaagttcagg taacactgaa tggaggcccg aacccacgca 168601 cgttgaaaag tgcggggatg aggtgtgggt aggggtgaaa tgccaatcga acctggagat 168661 agctggttct ctccgaaata gctttagggc tagcctcaag gtaagagtct tggaggtaga 168721 gcactgattg gactaggggc ccctaccggg ttaccgaatt cagtcaaact ccgaatgcca 168781 atgacttatc cttgggagtc agactgcgag tgataagatc cgtagtcgaa agggaaacag 168841 cccagaccgc cagctaaggt cccaaagtat acgttaagtg gaaaaggatg tggagttgct 168901 tagacaacca ggatgttggc ttagaagcag ccaccattta aagagtgcgt aatagctcac 168961 tggtcgagtg actctgcgcc gaaaatgtac cggggctaaa cgtatcaccg aagctgcgga 169021 ctgttcttcg aacagtggta ggagagcgtt ctaagggctg tgaagccaga ccggaaggac 169081 tggtggagcg cttagaagtg agaatgccgg tatgagtagc gaaagagggg tgagaatccc 169141 ctccaccgaa tgcctaaggt ttcctgagga aggctcgtcc gctcagggtt agtcgggacc 169201 taagccgagg ccgaaaggcg taggcgatgg acaacaggtt gatattcctg taccacctcc 169261 tcaccatttg agcaatgggg ggacgcagga ggatagggta agcgcggtat tggatatccg 169321 cgtccaagca gttaggctgg gaaataggca aatccgtttc ccataaggct gagctgtgat 169381 ggcgagcgaa atatagtagc gaagttcctg attccacact gccaagaaaa gcctctagcg 169441 aggtgagagg tgcccgtacc gcaaaccgac acaggtaggc gaggagagaa tcctaaggtg 169501 atcgagagaa ctctcgttaa ggaactcggc aaaatgaccc cgtaacttcg ggagaagggg 169561 tgctctgtta gggtgcaagc ccgagagagc cgcagtgaat aggcccaggc gactgtttag 169621 caaaaacaca ggtctctgcg aagccgtaag gcgaagtata ggggctgacg cctgcccggt 169681 gctggaaggt taagaggagc gcttagcgta agcgaaggtg cgaattgaag ccccagtaaa 169741 cggcggccgt aactataacg gtcctaaggt agcgaaattc cttgtcgggt aagttccgac 169801 ccgcacgaaa ggcgcaacga tctgggcact gtctcaacga gagactcggt gaaattatag 169861 tacctgtgaa gatgcaggtt acccgcgaca ggacggaaag accccgtgga gctttactgc 169921 agcctgatat tgaatgttgg tacagcttgt acaggatagg taggagcctt ggaaaccgga 169981 gcgccagctt cggtggaggc atcggtggga tactaccctg gctgtattga ccttctaacc 170041 cgccgccctt atcgggcggg gagacagtgt caggtgggca gtttgactgg ggcggtcgcc 170101 tcctaaaagg taacggaggc gcccaaaggt tccctcagaa tggttggaaa tcattcgcag 170161 agtgtaaagg cacaagggag cttgactgcg agacctacaa gtcgagcagg gacgaaagtc 170221 gggcttagtg atccggtggt tccgcatgga agggccatcg ctcaacggat aaaagctacc 170281 ccggggataa caggcttatc tcccccaaga gtccacatcg acggggaggt ttggcacctc 170341 gatgtcggct catcgcatcc tggggctgta gtcggtccca agggttgggc tgttcgccca 170401 ttaaagcggt acgcgagctg ggttcagaac gtcgtgagac agttcggtcc ctatccgtcg 170461 cgggcgcagg aaatttgaga ggagctgtcc ttagtacgag aggaccggga tggacgcacc 170521 gctggtgtac cagttgttct gccaagggca tcgctgggta gctatgtgcg gacgggataa 170581 gtgctgaaag catctaagca tgaagccccc ctcaagatga gatttcccat tccgcaagga 170641 agtaagatcc ctgaaagatg atcaggttga taggtctgag gtggaagtgt ggcgacacat 170701 ggagctgaca gatactaatc gatcgaggac ttaaccatat ttttgaatga tgtcacacct 170761 gttatctagt tttgagagaa cactctcaat ttgtttggtg gcgatagcga agaggtcaca 170821 cccgttccca taccgaacac ggaagttaag ctcttcagcg ccgatggtag tcgggggttt 170881 ccccctgtga gagtaggacg ccgccaagca attgcacatt agtgtaattt tttaaaaaag 170941 ttattgactt tgaagaagtg acattgtata ctaataaagt tgctttaaca aagcggacaa 171001 acaaaatgat ctttgaaaac taaacaagac aaaacgtacc tgttaattca gtttttaaaa 171061 atcgcacagc gatgtgcgta gtcagtcaaa ctactttatc ggagagtttg atcctggctc 171121 aggacgaacg ctggcggcgt gcctaataca tgcaagtcga gcggacagat gggagcttgc 171181 tccctgatgt tagcggcgga cgggtgagta acacgtgggt aacctgcctg taagactggg 171241 ataactccgg gaaaccgggg ctaataccgg atggttgttt gaaccgcatg gttcaaacat 171301 aaaaggtggc ttcggctacc acttacagat ggacccgcgg cgcattagct agttggtgag 171361 gtaacggctc accaaggcaa cgatgcgtag ccgacctgag agggtgatcg gccacactgg 171421 gactgagaca cggcccagac tcctacggga ggcagcagta gggaatcttc cgcaatggac 171481 gaaagtctga cggagcaacg ccgcgtgagt gatgaaggtt ttcggatcgt aaagctctgt 171541 tgttagggaa gaacaagtac cgttcgaata gggcggtacc ttgacggtac ctaaccagaa 171601 agccacggct aactacgtgc cagcagccgc ggtaatacgt aggtggcaag cgttgtccgg 171661 aattattggg cgtaaagggc tcgcaggcgg tttcttaagt ctgatgtgaa agcccccggc 171721 tcaaccgggg agggtcattg gaaactgggg aacttgagtg cagaagagga gagtggaatt 171781 ccacgtgtag cggtgaaatg cgtagagatg tggaggaaca ccagtggcga aggcgactct 171841 ctggtctgta actgacgctg aggagcgaaa gcgtggggag cgaacaggat tagataccct 171901 ggtagtccac gccgtaaacg atgagtgcta agtgttaggg ggtttccgcc ccttagtgct 171961 gcagctaacg cattaagcac tccgcctggg gagtacggtc gcaagactga aactcaaagg 172021 aattgacggg ggcccgcaca agcggtggag catgtggttt aattcgaagc aacgcgaaga 172081 accttaccag gtcttgacat cctctgacaa tcctagagat aggacgtccc cttcgggggc 172141 agagtgacag gtggtgcatg gttgtcgtca gctcgtgtcg tgagatgttg ggttaagtcc 172201 cgcaacgagc gcaacccttg atcttagttg ccagcattca gttgggcact ctaaggtgac 172261 tgccggtgac aaaccggagg aaggtgggga tgacgtcaaa tcatcatgcc ccttatgacc 172321 tgggctacac acgtgctaca atggacagaa caaagggcag cgaaaccgcg aggttaagcc 172381 aatcccacaa atctgttctc agttcggatc gcagtctgca actcgactgc gtgaagctgg 172441 aatcgctagt aatcgcggat cagcatgccg cggtgaatac gttcccgggc cttgtacaca 172501 ccgcccgtca caccacgaga gtttgtaaca cccgaagtcg gtgaggtaac cttttaggag 172561 ccagccgccg aaggtgggac agatgattgg ggtgaagtcg taacaaggta gccgtatcgg 172621 aaggtgcggc tggatcacct cctttctaag gatattatac ggaatataag accttgggtc 172681 ttataaacag aacgttccct gtcttgttta gttttgaagg atcattcctt cgaaacgtgt 172741 tctttgaaaa ctagataaca gtagacatca cattcaagta atacaagata tcacatagtg 172801 attcttttta acggttaagt tagaaagggc gcacggtgga tgccttggca ctaggagccg 172861 atgaaggacg ggacgaacac cgatatgctt cggggagctg taagcaagct ttgatccgga 172921 gatttccgaa tggggaaacc caccactcgt aatggagtgg tatccatatc tgaattcata 172981 ggatatgaga aggcagaccc ggggaactga aacatctaag tacccggagg aagagaaagc 173041 aaatgcgatt ccctgagtag cggcgagcga aacgggatta gcccaaacca agaggcttgc 173101 ctcttggggt tgtaggacac tctgtacgga gttacaaagg aacgaggtag atgaagaggt 173161 ctggaaaggc ccgccatagg aggtaacagc cctgtagtca aaacttcgtt ctctcctgag 173221 tggatcctga gtacggcgga acacgtgaaa ttccgtcgga atccgggagg accatctccc 173281 aaggctaaat actccctagt gaccgatagt gaaccagtac cgtgagggaa aggtgaaaag 173341 caccccggaa ggggagtgaa agagatcctg aaaccgtgtg cctacaagta gtcagagccc 173401 gttaacgggt gatggcgtgc cttttgtaga atgaaccggc gagttacgat ctcgtgcaag 173461 gttaagcaga agatgcggag ccgcagcgaa agcgagtctg aatagggcgc atgagtacgt 173521 ggtcgtagac ccgaaaccag gtgatctacc catgtccagg gtgaagttca ggtaacactg 173581 aatggaggcc cgaacccacg cacgttgaaa agtgcgggga tgaggtgtgg gtaggggtga 173641 aatgccaatc gaacctggag atagctggtt ctctccgaaa tagctttagg gctagcctca 173701 aggtaagagt cttggaggta gagcactgat tggactaggg gcccctaccg ggttaccgaa 173761 ttcagtcaaa ctccgaatgc caatgactta tccttgggag tcagactgcg agtgataaga 173821 tccgtagtcg aaagggaaac agcccagacc gccagctaag gtcccaaagt atacgttaag 173881 tggaaaagga tgtggagttg cttagacaac caggatgttg gcttagaagc agccaccatt 173941 taaagagtgc gtaatagctc actggtcgag tgactctgcg ccgaaaatgt accggggcta 174001 aacgtatcac cgaagctgcg gactgttctt cgaacagtgg taggagagcg ttctaagggc 174061 tgtgaagcca gaccggaagg actggtggag cgcttagaag tgagaatgcc ggtatgagta 174121 gcgaaagagg ggtgagaatc ccctccaccg aatgcctaag gtttcctgag gaaggctcgt 174181 ccgctcaggg ttagtcggga cctaagccga ggccgaaagg cgtaggcgat ggacaacagg 174241 ttgatattcc tgtaccacct cctcaccatt tgagcaatgg ggggacgcag gaggataggg 174301 taagcgcggt attggatatc cgcgtccaag cagttaggct gggaaatagg caaatccgtt 174361 tcccataagg ctgagctgtg atggcgagcg aaatatagta gcgaagttcc tgattccaca 174421 ctgccaagaa aagcctctag cgaggtgaga ggtgcccgta ccgcaaaccg acacaggtag 174481 gcgaggagag aatcctaagg tgatcgagag aactctcgtt aaggaactcg gcaaaatgac 174541 cccgtaactt cgggagaagg ggtgctctgt tagggtgcaa gcccgagaga gccgcagtga 174601 ataggcccag gcgactgttt agcaaaaaca caggtctctg cgaagccgta aggcgaagta 174661 taggggctga cgcctgcccg gtgctggaag gttaagagga gcgcttagcg taagcgaagg 174721 tgcgaattga agccccagta aacggcggcc gtaactataa cggtcctaag gtagcgaaat 174781 tccttgtcgg gtaagttccg acccgcacga aaggcgcaac gatctgggca ctgtctcaac 174841 gagagactcg gtgaaattat agtacctgtg aagatgcagg ttacccgcga caggacggaa 174901 agaccccgtg gagctttact gcagcctgat attgaatgtt ggtacagctt gtacaggata 174961 ggtaggagcc ttggaaaccg gagcgccagc ttcggtggag gcatcggtgg gatactaccc 175021 tggctgtatt gaccttctaa cccgccgccc ttatcgggcg gggagacagt gtcaggtggg 175081 cagtttgact ggggcggtcg cctcctaaaa ggtaacggag gcgcccaaag gttccctcag 175141 aatggttgga aatcattcgc agagtgtaaa ggcacaaggg agcttgactg cgagacctac 175201 aagtcgagca gggacgaaag tcgggcttag tgatccggtg gttccgcatg gaagggccat 175261 cgctcaacgg ataaaagcta ccccggggat aacaggctta tctcccccaa gagtccacat 175321 cgacggggag gtttggcacc tcgatgtcgg ctcatcgcat cctggggctg tagtcggtcc 175381 caagggttgg gctgttcgcc cattaaagcg gtacgcgagc tgggttcaga acgtcgtgag 175441 acagttcggt ccctatccgt cgcgggcgca ggaaatttga gaggagctgt ccttagtacg 175501 agaggaccgg gatggacgca ccgctggtgt accagttgtt ctgccaaggg catcgctggg 175561 tagctatgtg cggacgggat aagtgctgaa agcatctaag catgaagccc ccctcaagat 175621 gagatttccc attccgcaag gaagtaagat ccctgaaaga tgatcaggtt gataggtctg 175681 aggtggaagt gtggcgacac atggagctga cagatactaa tcgatcgagg acttaaccat 175741 atttttgaat gatgtcacac ctgttatcta gttttgagag aacactctca atttgtttgg 175801 tggcgatagc gaagaggtca cacccgttcc cataccgaac acggaagtta agctcttcag 175861 cgccgatggt agtcgggggt ttccccctgt gagagtagga cgccgccaag caagcttaaa 175921 cccagctcat tgagctgggt tttttgtttt atatctgtgc cgatttgctt tcgtcagtat 175981 ccattttatc aagcttctgc tttttaaagt tttctaatac ttttgaattc caatacaatc 176041 cctagcatga tcaacatgag agtcataaat aatcaaaatg cagtttgtac gggagactca 176101 tccagactcc atccgactgc gattggcagg atagagccgc caatccattg gcagcgaaca 176161 gcatgcttgt cgtttgttct gtttttccat gataaaattg attggtgaca ataaaataat 176221 ggcgaacatg ccggccataa ataagtccta agaaaaaact aagaataatc cctgcaaaag 176281 ctgttttatt gattgccaaa atacagagtt aaatgaggcc gctcatattt atcagcctga 176341 gataatgatg ataggttatt ttttcggaaa ccagctcggg ttgccaaatg agagaaaaga 176401 tattactgtc attaaaacga ttcttggttt catccggata tgataaaatg tctcagacta 176461 tatttgagcc atttttttct tcagcaatca tcttgcgtaa ttgataaaaa tttattatga 176521 tactctttgt atgacaactc cttgcctcaa tacaatatac tcaacgtttc cccgttttct 176581 ccggtcgttt ttcttttcat tttctcccgt aaaataaaaa aagctcccaa tacaatagat 176641 atggtgcgga tttatttttt actaaaaagg agtcgttata tttgaataat agttttacat 176701 taaaacagca atggttcggg aatatccgaa aagacattct tgctggcatt ttagttgcgt 176761 tagcgttaat acctgaagcg attggctttt ctattatagc cggtgtggat ccgatggtcg 176821 gtctttatgc gtcattttgc atagccatta ttatttctat ttttggtggc agacctggca 176881 tgatttcagc tgcgacaggc tcaatggcag tcgttatggt gtcgctggtt gctgatcatg 176941 ggcttcagta tttatttgcg gctacgattt tgacaggcat tattcaggtg attttaggta 177001 tcagtaaaat tgcaagatta atgaaattca tcccgcgttc tgtgatgatc gggtttgtga 177061 atgcgctggc gatccttatc ttctctgcgc agcttcccca gtttgaaggt gcttcttgga 177121 gcatgtatgc gatgcttgcc gggtcgttgg ttattattta tgtgctgcca aggtttacga 177181 ctgctgttcc gtctccgctt gtggcgatta ttgtgatgac aattattgcg gtcactttcc 177241 atgtggatgt gcggacggtt ggtgatatgg gcaatatttc tagttcattg cctcatttct 177301 taatccctga tgttccgttt acctttgaaa cactgcaaat tatttttcct tattcaattg 177361 ctttagcgtt tgtcgggttg cttgaatctt tgctgacagc acagattatt gatgaaatga 177421 cggatacgga tagtgataaa aataaagaga gccgcggaca gggaattgcg aatatcgtga 177481 ctggattctt tggcggaatg gcaggctgcg ctatgatcgg acaatctgtc attaatacaa 177541 aagcgggcgg tcgcggacgt ttgtcagcat ttgttgccgg tgcttttctg atgtttttaa 177601 ttgcggtgtt aagtcatgtc gtggtgaaaa tcccaatggc ggcgttagta gctgtaatgg 177661 ttatggtgtc tgtcggcact tttgattggt cttctttaaa aggtctcaaa aaagcgccgc 177721 tcacggactc gattgtcatg gttgtgactg tggttacggt tgttgtgacg gatgacttat 177781 ctaagggtgt atttgtcggt gttcttttaa gtgccgtgtt ctttgtagca aaaatctcga 177841 agctgaaaat cgtttctcat gcagaggatc aaaagcttag aacgtatcaa gtgaaggggc 177901 aaatcttttt tgcgtcagtg actgatctta cgaatgcgtt tatatatcaa gaggatattg 177961 agcgggttgt gattgactta actgaagctc acgtatggga cgattctggt gcggccgcac 178021 ttgataagat tgttgcgaag tttaaggaac aaggcattga agctgagtta aaaggtttga 178081 ataaagcgag taaatctcta atgaaacaga tggcataaaa tagagaagcc cagatgaatg 178141 agatctgggc ttttttatat aacatacact taagcagcat tgatataata gagagaagag 178201 aaattttaaa taggggactt gcatatgatg cttcagaagc tgaaccgtgt attggggaga 178261 gtgatgccgc tgttaacgcc gactagtgtg gtgctgggcg tgctgctgtc tcagttttta 178321 aatgggtatg aatgggctgt gccttggatc tttgctttta ttacgtttgc aggcagtttg 178381 agcgcgaact ttcaatcttt gagacatgca ttgtctcatc ctctccctat gattcttgca 178441 ctattcgttc ttcatatttt catgccgctt tttgcttggg gcagcggcca tcttatattt 178501 aaaggtgatc ctttgacgat taccggttta acattggctg ttgtgattcc tacggggatt 178561 acaagcttga tttgggcagc gatgtacaaa gggaatgtcg gtttgacact ttcgattatt 178621 ttagttgata ctgtgctgtc accgctaatc gtaccgctga gtctttcatt gctggccggc 178681 gctcaggttc acatggatgt gtggggaatg atgaaaggtc tgattgtaat ggtcgtgatt 178741 ccttcttttt tgggcatgct gtttaatcag atgtcatctc cagaaagaac tgcgtttgtg 178801 agcagtgcgc tgtcgccttt ttcaaagctt tgcttgatgg cagtgattgc gattaacagt 178861 tcagcgattg ctccttattt caaatccatt gatttgagat ttgcaggaat agctgtaacg 178921 gtattcttta tcgcgttaac aggttatgcc gctgcttggc tgatcggaaa aatgatgaaa 178981 aggcggcaag aggaaatagt ctctcttata tttacgggag gcatgaggaa tattagtgcc 179041 ggcgcagttc ttgccgttac gttcttcccg tctcaggttg ccgttcctgt tgtgatcggc 179101 atgctgtttc agcagatatt ggctgctttg tttggctata tgctgaatcg ttttgaatta 179161 aaaccaatgt tgcagaaggc ataaaaaaac cgctcatagg gttgagcggt tttttccgta 179221 tagccattcg agcgcgttga tgaactgttt gcagaaatac ttgtggtggt gcaccgctcc 179281 tttttcaatt gaaagacaca actggtcttc agtgaagcct ttttctttta gactttgatg 179341 aacttgcttt gtttttttca gcatatgtcg ctgaatggat tgtttttcac ggccttcttc 179401 actcccgata gacatgaaaa cacgtgcagt gccgggcttt aaagaagata tatgaatggt 179461 ttccgctgcg ttctcgtacc agtatgaacc tgatatagag cctattttcc cgaacattga 179521 cggatatttt aatatggcga acattgagat gaggccgcct aatgaggcac cgatcattcc 179581 tcttgactgc ggttccctgg tgacgttcca gttttcttcg attagcggaa tgaactggtt 179641 cgttatatca gacagatagt gatatcccat tccgccgaag tccgtgaacc gatcactgag 179701 tgatgcagcc ggccatgggg tgtattcatc aagccggttt tcgggttcga taccgatcag 179761 cacgagttca gggagccttt gctgttgaaa ggcgctttct agtaattcga tttggttttg 179821 gaacaaagaa ctgccatcct gcacgtaaac agcaggaaat cccccgctgt ctgtgctgta 179881 ggaaggaggg aggtacagcg tgaacctcct gttgccggct ttgtgttctg aaagagatcc 179941 tttcaagcat tctccccctt tttttgcttg aaaagcagat ataagaaata aggaactccg 180001 aggatcgcca aaatgatgcc tgcgggcact tctgcgggct gaaaaaacag ttttccggca 180061 aagtctgcgc ttatcacaag aagcatcccg attaaaccgc tcagtggcag gatatagcga 180121 tgttcgacgc cagccagtct ccgtgagata tggggagcaa ttaagccgac aaacgccata 180181 cttcccgcta cggagacaca ggcgctgatg attgctacac aggcaacgag aaggatggtt 180241 ttttctttat ttgatgaaat accgaggctt ctgactgtgt cttcatcaaa acgaatggtg 180301 tcgagcaggc gggatttgcc gataagaatc ggtataaaca gcagcatcca tgggagtaca 180361 gctgtaatat acgtccagtt ggcagaccag atgcttccgt ttttccacac catggccatt 180421 tgatagtctt gcgggtccat ttttaaagat aaaaacaaag acagggcgct gaatcctgaa 180481 ttgatcgcaa tccctaccaa aataattctt cctgaatcta aattgcctct gtgccatgca 180541 aatatgtaaa tcaggatcgc cgcgatgagc ccgcctatca atccaaagag cggcattccc 180601 atcgctgcag ctatggatgt cacttccttc tggccttgga ataagagcat aaacgctaca 180661 atgccagctc ctgcccctgc gttgattccg agaattccag ggtcagcaag cccgtttctc 180721 gtgatggcct ggataacagc gcctgcaatg ccaagaccga gtccaataat agcagccatg 180781 acaacccgcg gcagtcttaa atcgaacagc aaaatttcat actgcggatt cgggtcgatt 180841 tgaaaaagag tggagagcag ctcagcagga cgaacagaaa atgatccgct cgttaagctg 180901 aaatagctga caacaagaat caaagcgatg aacaatgcat attttttagc cattttgctc 180961 ccctcctttt cgtttaatta aataaaggaa gaaaggtacg ccgataatgg atgttacgac 181021 ctcaatcggt gtttcaaacg gatagttgat aaatctgctt gcgagatcac acagggttaa 181081 aaagattccg cccaaaatac aggaacacgg aatcagcctg ctgtaatcag agccgacgag 181141 aaatctcgtg atatgcggaa caaccaaccc gacaaacgca atttttccgg ccagcgctac 181201 ggcactgccg gttagaatga tgacggaaag catcgccatg attttaatgg tttttttctt 181261 ttgccccagg cttttagaaa tgtcgtcccc taatgataca gcggttacct ttttgctgag 181321 agaaatggcc attataatgc caatcaggaa aaacggagcg gcaagcttca ggaaatctgg 181381 actcatttga tgaagtctgg cactgtacca gaaactgaga tcctgagaaa tttgaaaata 181441 aatcgacatg gccgctgata agctgctgag cagcatgctt gtgactgtgc cgatgatggc 181501 gagctgcacg ggggtaaatc cgtttggcat catggcggca aggccgaata ctaacaccgc 181561 tcctaacgct gagccgataa aagagtatat catcatttca atcgaagatg attgcgggag 181621 cagaaccatg caaagcgtaa tgataaacgc tgaaccatct gaaacaccca taatggatgg 181681 cgaagctaaa taattgcgcg taatgccctg cataagcgct ccagaaacag caagggctgc 181741 ccctatgagc agagcgccgg cagcccttgg aatccgggaa tgccatataa tttgatggtc 181801 tgtgtttccc ggatcgaaat gaataagaga tgtaaaaaca atatctgtgc tgagatgctt 181861 tgccccataa aggattgaaa gcaaaagtga cagcgctata gcaaatggag aagtaatcaa 181921 tatgatacgt gtccactgtt ttgaatacat acaaaaacct actctgaatt agttttgtgt 181981 caatttttca gcagccgctt tcaggaaacg gactttgctc caagctgtgc cgccttgtgc 182041 gagagggtcc actgagttga catacacatg gtcttctttg actgctttaa ggcttttcca 182101 gattggattt ttctctaaat cttttaaggc atcaggtttg tctgcatttt catcatcaga 182161 aaattggacg aaaatatggt ccgggttcat ttcacttaat ttttctaatg aactcagctc 182221 ttgcgctttt gcagccttta cttcgttcgg cgccttaagg cctaaatcac cgtatagtgt 182281 ggagttgaaa tacacctgtt cagggtaaat gtaaatgttg ccttgtctga ttctgatgac 182341 aagcgctttt gaatctttcg ctttatcgtt gatttttgtt tttatttctt ttagatcctg 182401 ttcatagtct gcaataattt tctttgcttt tttctctttt ccagtcagct gggcaagaag 182461 catcatgttt tccttccagt ttgaagagat atgagaaact gggatcgtcg tgcctgctgt 182521 gctgattttt tgcagcgttt tttccggaaa ctttgttgaa gcaaggataa catctggctt 182581 catttcaaga atcttttcaa tatttggctc cattttttct ccggttggtt cggctttatc 182641 agtgatgtct ttgaacatat cagggaattt gccggagaat gaaattgcgc cttgcggatg 182701 aacgtcaagc aatttcgcgt cttccattga ttcaacgctt cccgtaatgg caattttgtc 182761 tgtcggtaca gttacttcat atgttttatc aaggtattca attttcttct tctcagatgc 182821 tgtgccgctt gccttgctgg cagttgattc atttttgctg ccgcaagctg ccgccgtcag 182881 cgcgagaagt aagattaata aggtaagaga tatctttttc atctatagag cctcctgttc 182941 aattgataac tattatcaat tggaattata gagaatgaac agatataaca ccatggacaa 183001 attcctgatt tatcatggac aatctccgga tagtaaagaa acagtttgct gaacgatgcg 183061 ttcgtgcccg caagctgagt attcattcca cgggtcaagg gatagaagat aaacacggtt 183121 atctcgtacc gcgcttaggt tttgccatgc ttctgtctgc tgtaattgct ggtagtaagc 183181 tatggtctcc ggctctttaa aaagaaaaag catcatacag tcagcttggt aatttgcgat 183241 attttctaac gaaatcgctt gttctgaagg tgtgtcagcc gttgttgccg agctgaatcc 183301 taaatcccca aagaaaactt cgcggacact tcggttatga gccagataga agttttgctt 183361 atgcagcctc aaaaagagaa aacgcagccc ttgaacgtgc tgaagtgttt ttttggcggc 183421 cgttgtctgc tggtcataat ccgctagcca cttttctgct tcggactcct cctttaaaaa 183481 tgaggcagtt tgcagaaagt gggttctcca gctttcttct gaaggaaggt acatgacttc 183541 tgcgatgcga ttcaggcgat cttgttcttc tggagaaata gaatccatgc tgacaatcac 183601 atctggttct gcctgtgata acgtgtacag gttttcttcc cacttttcat taaaccggta 183661 tgcactgagc tggacgggta tatctgtcga ataatgctga tagtagtaag acgtccattt 183721 cggatgcaga gcggccgcaa aaggtatgtg gtgaagaggg atgagatggc ccattgtgcc 183781 ccttccgtat gcggcgattt tctttcggcg ttttttcata tagcttgtag gtgaacagcc 183841 tgtatatttt ttaaagattc tgctgaaata aaattcatct tgataaccgg tttggtgtgc 183901 gatttctttc aatttgcagt ttgattttgc catgagccgt tttgcctttg tgattcgtgt 183961 tttcgtaata aattctgtta cgctctgtcc tgtccatttt ttaaagcttt cactgtagtg 184021 tttggcactg attcctgcca tttgcgacag ctgggcaagc gtgatttttg tatcggcatg 184081 ggtttcgata tagtgttttg ttttttcgat tgctgaatgt gtatccgttt gatcagataa 184141 actggcagta aaaagatcat aaatcaggct ttgtacttca atcacacatt ttagctgaga 184201 aagctgagac gattcattcc atagtgcggc aagctcttga agccggactg caagattttc 184261 gatatgtgaa acattcataa gcttcagttt ggctaattcc gattctgtgc acggtgtgaa 184321 aatatcttgc ccggtttcct tgatatagct tagaagcctg attatacagg catctatatg 184381 tccatcggct gctggcgtaa agccaaaggt ctcgttaggc ggacaaacat aaagtgtctt 184441 tttttgcaga ggattggtgt ttgttccgat cgaaatatag ccgtttcctt ttaaatgaaa 184501 aatcagcacg aatgaatcgg ctaattgctg ttctgagaag agatcacttg tcttttttag 184561 atattcaatt tgtactggtt gataaatcac tgcattttgc acgagtagac caccttttca 184621 gaagctttca attgataatc attttcaata aaaattgtac caaataaatg aaagttttcc 184681 tatataaagc gggtgggttt ttagcatgaa aaaaaccctt acttatgtgt aaaagtaagg 184741 gtctttcgtt caataagaat atgttacacg tgtaacatac gatgcttatg ttctaataaa 184801 tgagatactt ttttcttgtt ttgctgaatt gttggagtgt tttttcatag ctgtttatga 184861 tgttctcaac cgaagttcca ttttcaattt ttgtcctgat ccagccgttg cctgccagtt 184921 tatcgaatga acctgttgac aggaactcaa aatcctcagg atagagatcg tgtatggttt 184981 taatgactga aagacccgtt ttaacggctt caaacttatc tctgtctgtc acatagagct 185041 gcacaccgtg gcaaagcgtt ccttgatgtt tagaaaacgt cggtgtgaag gatgctgccc 185101 taaatgtaac gcccggcaaa tggaggctgt ttaatgtttc ttcaagttct gtgcttttga 185161 taaagggagc tccgatcaat tcgaatggct ttgttgtccc tcgcccttcg gatatatttg 185221 ttccttcaat cagcccggtt gcaggataaa caaatgtgct ttccaccgtc ggcatgttag 185281 gcgaagggag gacgaaaggc aatcgggtat cgtcaaaatc catttttcgt ttccagtgtt 185341 tcatttttac cactgtaaga tcggcatcaa tactaaattc tttgttgaac agtgaagcca 185401 attcgcctat cgtcatccca tgcttcaatg gaatgggata caatccgaca aatgaggcgt 185461 attcaggttc taagattggt ccttcaatat gattcccgcc ttgaggattc ggacggtcca 185521 gcaccataaa tggaatgccg ttttctttag cggcttccat tgcgtatgcc attgtataaa 185581 tgtacgtgta gaaacgggtc ccgacatcct gaatgtcaaa cattagaata tcgacatttt 185641 taagcatttc tggagtcggt tttttcgttt ttccgtagag gctgtatacg ggaaccccgg 185701 ttttttcgtc aatgtaagag cctacttcgt ctccagcctg ggcgtcaccg cggacgccgt 185761 gttcagggcc gaataaagct gtcagtttga tatccgggtt ctcgtaaagg atatcgacac 185821 tgctttttag agatgtgttt actccggctg gattggtgat cagtccgatg cgttttccct 185881 tgagctgttt tttatagtct ggcaagagcg tgtctatccc agtctggact ttaggttttt 185941 tagctgtttg attctttgaa tcgggtgaag cagaggcagc ggttatcgtt ccgaacatca 186001 tgagccctgt cagaaaagcg aatattgttt ttctcatgtg tccctcctta ttaaagcggt 186061 cttcccgttt tgatatttaa tccgtagcca agtgggtaaa gggtgttccc tggtttcgtg 186121 actgacggaa tgtcaactgg aagtgtgcct ttaggttttg cctggccgaa tatcgccatc 186181 actccggccg gaatattagg ttgaagataa cggccatttg cgtatccttt aaagccatag 186241 actgcaatca gtgcttttgc ttcttcgaaa ttggctgcgt cataggggtt gcgcaggctc 186301 attaagacaa atggtttgtt gtgctgcagt gcggctttca tgacagctct cggaaacacg 186361 gtggcccatt tgcttgaatc tgatattgtg tcgtcgatga caccgtcgtt gacgacaggg 186421 tcatttttga cgacatagga gccggtaatg atataatcag cctcttttac ttgtttttca 186481 tgctcggtct taaatacttg gctggcaaag ttcattttgc tgagggatac gggtttgatt 186541 ttctttcgct tgatgagatc gtgaatggtt tgttcgattg aagcagtttg ttcttcgtaa 186601 ggtgccacaa ttaagattcg gctgcctttt ttaggcttga acggcaaagt gtgctgttca 186661 ttttttaata cagttactgc tttttcagct aattttttct ctgctttcag gtgctgcttg 186721 cttcctacga tttttttggc tttggctatt ttttcttttg tactgtcgct gtttcgcgct 186781 ggatacatgc cgcgttttat tttcagggaa atgattcttt caactgaatt gttgatttgt 186841 tgttcaggaa tatccccgtt tttcacggct tctttcaaag cttgaataac acgtgcgaat 186901 ttctgttctt ctttcaatga agtgactgag gctggcatta atgcaatatc gacaccagct 186961 tttacggcca tgaccacagc ctcttcctgt ccgaaatgat ctgcgattgc cttcatattg 187021 agcgcatcgg taacgatgac cccattaaag cccatttcct gacgaagaag acctgtcatc 187081 actttttttg aaagtgtagc tggaaccaga atgtccgatc catcgagttt gcttttgtaa 187141 gtggtgtcat caaaggcggg aaactgaaca tgggctgtca tcaccatatc agcaccagca 187201 tcaattgctt tttgaaaagg ataaagctcg acctcacgaa gccgttcttg gccatgggaa 187261 acgagcggca gtccataatg gctgtcaacg tccgtgtctc catgtcccgg gaaatgtttg 187321 agggcagacg cgatatcctg ccgctgcaac cctttcatcg tatataaacc gaggcgtgat 187381 gtcagttctc gattggagct gaatgaccgt acgccgatta caggattatc aggattattg 187441 ttaatgtcca cgacagggct gaaatctgta ttgatgccta aggcagagag ctcttttccg 187501 atgatgctgc cggtctgata cgcattgatt ctgcttctgg ctgcgcccag cgccatattc 187561 cctgggaaat tagtgccctc ccctaacctc gttacaatgc cgccttcctg atcaatactc 187621 agcatgagcg ggatttttgg acttgccttt tggtaatcgt ctgtcagttg gacagtttgt 187681 tttgttgttt ttacattttc tgcaaaaagg atgatgcctc cgaattgata tttcttgacg 187741 aggctggcga cttcatcatt catttttgta agggcttgcg gagaggactc gccttccttt 187801 tgccaatttc taaaatcagg catcagcatc tggccgagtt tttcatctaa cgacatacga 187861 ttgacaatct gattggcatc gattgcacgt ttggatgcag aggcttctgt ctgtctggcc 187921 ccgaaaaagc atgaaagaaa gagaacggct gaaaggataa gcggaaagac aggtctcata 187981 gaaacttcct cctatcgtct aatcattcac tccatcgctt cataaatcgc ggttatgaca 188041 cttccataac tgcctgttgg aaattggtca ccttcaaaga cgttcggatt ttcttccgga 188101 tcaataactg gtgtatgctt tttatttgtt aacaatgcga tgcctaaatt gtatgctgga 188161 tcaataattg taactgtccc cgtccagccg gtatgcccgt aagcattttc gctggcatga 188221 gggccaaaca tccattccat gcttttactt ccgttccgcc tccagccaag agcgaatgtc 188281 ggatctgttg ctgaaggtgc tgtaaacagg tcggctgttt tctgatcaaa taaagaaatg 188341 tttcggtatg aacctttgtt taacatgact tgcagcagta tggccatatc atctgcattt 188401 gagaacaatc cggcatgccc agacacgccg tccattgagt aaaacgcttt ttcgtcatgc 188461 acctctcctt gcagcgtgtt tgtgcggatg ttagggaatt gaataacgcc gtcacgtgta 188521 ttgcccatgc gttcagtagc tgcgaactgt ttcggtttaa agcccttttg cagcggattg 188581 tacaaggtat gcttcagcct gagcggtttg tagagctctt gctccgtgta gacatcaagc 188641 ggtttgccgg tgagtttttc gacaatacat ccgagtagca tatatccaat gtcactgtat 188701 acgtgttttg tcccggtttg ataatcgagc ggaattttcg tcaaatattc aatcgttttg 188761 tcccgttctt gggaatagta cttgccggct ttttccggcg tgtaaaagta aaagcttgat 188821 gggagccctg attggtgctg gaggacatca atgacacgta tcttgtcttt tccttttatg 188881 aggtcacccg gctgatcctt gaaacccggc aaatatgcag aaactttttc atagacgtca 188941 agttttcctt ggctgactaa gcgctgcaat gcaaaatttg ttgcgtacat ttttgtattt 189001 gaggctaagt caaacatcgt gcgggttttc attttggccg gacggcgcag cagttctgat 189061 ccttcgtact ttttactgta gccgtatgct gcttttttta tgatgcgtcc atccttcacc 189121 accacaagaa cggcgcctgg aaatcctgct gcaatatccc gttctatcat ctgatctacc 189181 ttccttagct tcttcgtcga gaattgtgca gtttctgcat ttatgatttt cggctcaatc 189241 aagttgcctg ctgtttgtgc gaaggtttca tttggcgcaa atatcgatag ggttaaaatg 189301 gcactgaata tgaacagtgt ctttgttttc acaggctagc ccctttctgt gcttctatcc 189361 cgtttactat ccctaaaaca gaaacaattt aatcgaactg agaagccatt tcatctttat 189421 atccgaatgc ataggtcaat aaaaaaccgg ccgcgtagga aataaagagc ccaacgatat 189481 acaggatgat ttgcgaaggc aggactagaa aagatagcgg cagtccggag acaccaatcg 189541 caatggtggc tacttgaaaa taagcttgaa aggcgccgcc gattccagct cctaaacatg 189601 ctgttaaaaa cggacggcca agcggcagcg tgactccgaa aataagcggt tcaccaatgc 189661 cgagcagtcc cgatggaagc ccgccggcga ttgctttcct cagtgttgtt tttttcgtct 189721 tcacgaaaac ggcaaaggcc gcgcctacct gtcctgcacc tcccatagcc aaaataggga 189781 gcagaggatc attgccaatt gaattgatca gttccatgtg cacaggcgtc aagccttgat 189841 gcagtccggt tacgacgaga ggaaggaagg ttgcgcccag aataaagccc gcagcgatgc 189901 cgccgatgtc caggatggac agtaggccgg atgtaatagc atcagaaatg aatccgccta 189961 aaggcataaa tacgacatac gttacgattc cggtgattaa cagtgaaacg gtgggtgtga 190021 caatgatatc aagtgattga ggaataaaac ggcgaataaa ttgttcggtg taagcaatga 190081 atatggctgc gaaaaggacg ccgatcagac ctcccctgcc cgggagaagc tcttctccaa 190141 ataaactgat ttttgcgatc tccggattga taatcaagat cccggccaaa gccccaagtg 190201 cgggtgtccc gccaaattct ttcgaagcgt taataccgac gagaatgccg agataagtga 190261 acagccctga tccgatgact gtcaggataa tcgcaatttg tgagtctgca gagagccagc 190321 ctgcttgaat aattgctttg gtaatcccag taattaaacc ggaagcgact agagcgggaa 190381 taagagggat aaaaatgctg gcaattttac gtaagaaaag tttaaaagga gtggcatttt 190441 tccgattgat atcggctttc tttttggccg ctgcttcttt gacatcggca ccttcttctg 190501 ctgacacgag ctttgagaaa gcagctgtaa catgattgac aactcctgtg ccgaggataa 190561 tttgtaaggt ttcagcttca acgaccccca atacgccgtc aagctttctt aaagcctgag 190621 catccgcttt gctttcatcg taaggcgtaa tgcgcaggcg tgtcatgcaa tgcgtatatg 190681 aagaaatatt ggattttcct ccgcatagct caaggatttt ctgtgcgaga tgatggtagt 190741 tattttcttt gctcattaaa acccctcccc ttcaagatgc cttattttat tctcatagat 190801 tgtatggctg ctctcgtttt atctatataa ccggttgtcg tttcatactg ctcagccgcc 190861 atgcctaaaa acaaaacatc aattataaaa agctgggcga ggcgggaaga agtggctgca 190921 cttcgaatca aggcttcatt ggaatgggct gtatacaaag ggacatcagc cagtgcggag 190981 acggatgtct gactgaattg tgtgaggctg atcgttgtga tgcctttttc cttagccatg 191041 gcgaacagtt caacgatttc ctgtgtctct cctgaaaacg aaatggcgaa tacgatgtcg 191101 tctttatctg catttgcgat taaagatgcc acaagatgag tgtctgtaaa cgcggttgct 191161 tgtttatgaa tgcgaagcca cttttgctgg gcgtccttgg cgacaatgcc ggaagccccg 191221 aggccgataa aatgcacggt atgagctttg agaagcagag aaaccgctcg ttcaagctct 191281 ttgtagtcca tcaggtctga agtatcctga atggcttgaa tggcattgcc ggccgttttt 191341 tcggaaatgg agggcagcgg ctcgtgggga acaatatccc ggtagccctg aaacgtaggc 191401 tttgccagat cgcctgctac tctcattttt aaatcttgaa atccttttaa accgagtgat 191461 ttgcagagcc tgatgacggc agcgtcactt gaattggcta aggcgctgat ttcgttgacc 191521 gtgctttcga ttgctttgtg gggatgggct aggatataat ctgcaagttt gcgctcggat 191581 ggagggagct tatgcttcat tgattggatg atcgctaaac cgcctgtggc cattctagtt 191641 ctctccttat catggatggt aatgttcgat tgctttgtca atgaaaccgt ttgcttcatc 191701 gagtaatgtc tgtgcttgtt tctgatctgt gcttgttttg agcatgacga ttgctgtttt 191761 gacgtgatga tcggcttgtt ccagagtgta tctggctgtg tcgtatgaag cgtttgtaag 191821 gctttggatg atgctgatgg cgcgttcttt tagttttttg ttgctgacgt tgacgtctac 191881 catcaagttt tcgtaaacct tgccgatttt gaccattaca gcggtagata tcatgtttag 191941 aatcatttta tgagcggttg cggctttcat acgtgttgat cctgtaatgg cctcaggtcc 192001 gacgacaacc tcaatgctgt gatccgcatc cttgctgatg gcggaatttt cattgcaagt 192061 aagggcgatg gtgtgtgctc cgactttacg ggcgtatctt agggcgcctg cggcgtaggg 192121 tgtgcggccg cttgctgcga tggcaatgac ggtgtcattt gaagtgagct gtatgtttct 192181 taaatcttca gctcctgctt cttcactgtc ttcaatgccc tctgctgcct gtaaaaaggc 192241 ttcggggcct ccagccatga ttccgatgac ctgatctggg cttacgctgt aggtgggagg 192301 acattcaaca gcatccatga cgccgagtct gccgcttgtg ccggcgcctg tatatatgag 192361 ccggcctcca ttttgaaacg attcatatgc gcagtctaca gctgttttga tgtcggggag 192421 aacctcctga acggctgcag cgactttcat atcttcgttg ttgatcattt taaggatgcc 192481 gagagtgttt gctttgtgga tttcaactgt ttgactattg cgtgattccg ttgtaagacg 192541 gtgaaggttt aatggttctg acatgaggat gccccctgtt ttaaaatgat atatctcaat 192601 attcagtata ttcatttctg ttatgatatt tcaactatgt ttttaaattt ttgaaatttt 192661 atttcactta agactataag aaatgatgaa ggatcaactg ttctccaagc ggcccgattc 192721 ttcgccgtcc tttatcaagg aacccgcttt tcatataaag gtgttttgcg cgtatgttca 192781 gatgattgac ggccaagatg atttcgtcgc accatggaaa atatccgctc acaaaagcgg 192841 gaagcaaaag catggctttt ttcgcatagc cttttccgtg atgcacagcg gttaaagaca 192901 gggagctgag cagtaaagca aatggattgt tagaatagga agcaagcgtt tcttttgatg 192961 catgtaaaat gaaaaaaccg actggaaggt cgtcttttaa gatgacaacc gggtatcggt 193021 cctgtatgcc cagagcctga gacagcacct ctttcgggag ggaggtaaag cgtttgtcat 193081 cgttggtgag cgtgaatgat tggagctcgg gcaagtgttc aggcttatag aaggataaag 193141 aaatgtcttg agtcatgggg tggcctcctt acaatatgtc gttaagctcg ttttccgaaa 193201 tgacgcggta gcccgcttgt tttaacagtg cggcggttac tccgctgccg gtgatttttt 193261 tgccagagaa tgtgccgtta tagataaaac cgcttccgca agatggactg ttttctttta 193321 atatgacggc agaagcgttg atttcttttg cgtaagccaa tgttttcgcg gcgccttcca 193381 tatatagttc tgtgacgtct tctcctgaag ctgtcacgat tttcgctgtt ccattgagga 193441 catcctcgcc agtgcctcct atgatttctg cgggttcgcg tggggtagag aagccgccga 193501 gaagttcagg gcaagccatg actgctttct tttcatcgac tagttttctg attttctccg 193561 acgctgcgtg agagccgtta tatctgcatt caatgcctcc aaggcaagaa ctgactagaa 193621 tcatattggt ttctcctctc ttgctttgct tgtctctatc ataaaataaa tggctttagt 193681 tgggaggctt tttcagttaa aaaaggagtt aaaaagtttg aaaataaaaa atttaatttt 193741 cctctttaca aacagggggt gacctgtata taataacttt tgtcagctcg acgagaacac 193801 aacggcccgt tggtcaagcg gttaagacac cgccctttca cggcggtaac acgggttcga 193861 atcccgtacg ggtcaccatt tggaggatta gctcagctgg gagagcatct gccttacaag 193921 cagagggtcg gcggttcgag cccgtcatcc tccaccatct tgccggtgta gctcaattgg 193981 tagagcaact gacttgtaat cagtaggttg ggggttcaag tcctcttgcc ggcactgttt 194041 tttcaaaatt ttatgtggag gggtagcgaa gtggctaaac gcggcggact gtaaatccgc 194101 tccctcaggg ttcggcagtt cgaatctgcc cccctccacc attattgggc tatagccaag 194161 cggtaaggca acggactttg actccgtcat gcgttggttc gaatccagct agcccagtca 194221 cagacacctt tgatcaaaag gtgtcttttt tcttttcgga aaaatcattc caacttctaa 194281 ctgttcagtc tgtataataa ttttaaaaat atgttaaggt agtttattca cgaattacca 194341 tctacaccct gccaaaaatt tgataaactt attttataaa aaaattgaaa ccttttgaaa 194401 cgaagctcgt atacatacag accggtgaag gcagaggtta gataaatatg gaaatgatga 194461 ttaaaaaaag aattaaacaa gtcaaaaaag gcgaccagga tgcatttgcg gacatcgtag 194521 atatttacaa agataaaatt tatcagcttt gctaccgtat gcttggcaat gtgcatgagg 194581 cggaggatat tgcacaggaa gctttcatca gagcgtacgt taatatcgac agttttgata 194641 ttaaccggaa attttcaact tggctttatc gaatcgcgac caatttgacc attgaccgca 194701 ttcgcaaaaa gaagccggat tattacctcg acgcagaggt ggctggtacg gaaggcttga 194761 ccatgtattc tcaaatcgtc gcagatggtg ttttgcctga agatgcagtt gtatcgctgg 194821 agctctcaaa cacgatacag cagaaaattt taaagcttcc tgacaaatac agaacagtca 194881 tcgtattaaa gtatattgac gaactctcat taattgaaat cggggagatt ctaaacattc 194941 ctgtggggac tgtgaaaacg cggattcaca gaggcagaga ggctcttaga aaacaattaa 195001 gggatcttta agtggggtga tgaaatgagc tgtcctgaac aaattgtgca gcttatgcat 195061 atgcatcttg atggagatat ccttccaaaa gatgaacacg tattaaatga acatctggag 195121 acatgcgaga aatgcagaaa gcatttttac gagatggaga aatccatagc gctcgtacgg 195181 agcacatcgc atgtcgaagc ccccgcggat tttaccgcta atgtcatggc aaaattgcct 195241 aaggagaaga aaagagcttc tgtaaaaaga tggttcagaa cccatcccgt tatcgcagct 195301 gctgcggtat tcatcatttt gatgggcggg ggttttttta acagctggca taatgaccac 195361 aatttcagcg tgtccaagca gccgaatctt gtggttcata accatactgt gaccgtgcca 195421 gaaggtgaga cggtcaaagg tgatgtcact gtcaaaaacg gcaagctgat tattaaaggc 195481 aaaatagacg gggatgtaac cgtcgtaaac ggcgaaaagt atatggcctc tgctggacaa 195541 gtcaccggtc agattgaaga aatcaatcag ttattcgact ggacatggta caagatgaag 195601 tctgcgggga aaagtgtact cgatgcattc aatccgaacg gagaagagta aagcgcgtta 195661 gccgctttgc tctttttttg cgggctgaga gggctggcac atttcacttg ctaaatcgaa 195721 atgtggtata atgggctcgc tatgtaaagt acatatgcgt aacacgtaaa acacaaaata 195781 cgaaatgact gaaatcttgg aggacgagga aatggctttt gaggatatcc cttttttgca 195841 gtacctcggc aatgccgttg atattctcct tgtttggtat gtgatatata aattgattat 195901 ggtgatacgc ggcacgaaag cggttcagct gttaaaagga attgtagtca tcgtgcttgt 195961 tcgtatggcc agccaatatt tgggcctcag cacacttcaa tggctgatgg accaagcgat 196021 aacatgggga tttttagcaa ttattattat ttttcagcct gagctgagaa gagcgcttga 196081 acagctaggc cgcggccgct ttttttcgag gagcggcacg cctgttgaag aagcgcagca 196141 gaaaacgatt gaggccatta caaaagcaat caattatatg gcgaaacgcc gtataggcgc 196201 cctgctgacc attgagcggg atactggaat gggcgattat attgagaccg gcataccact 196261 aaatgccaaa gtcagctctg agctgctgat caatattttt attccaaaca ccccgcttca 196321 tgacggtgcg gtaattatga aaaataatga aattgccgcg gccgcctgtt atctgccgct 196381 ttctgagagc ccgtttattt caaaagaact gggcacgcgg cacagagcag ctgtcggtat 196441 cagtgaagta acagacagtt tgacgattat tgtgtctgaa gagaccggcg gcgtcagtgt 196501 ggcaaagaac ggcgaccttc acagagagct tacagaagaa gcgctgaaag aaatgcttga 196561 agccgagttt aagaaaaaca ccagagacac ttcttctaac cgctggtatt ggaggggcaa 196621 gaaaaatgga taaattctta aacaaccgct gggctgtgaa aattattgct ctgcttttcg 196681 cgctcttgct ttatgtggcg gttaacagca accaagcacc gactccaaaa aaaccgggtg 196741 aatctttctt tccgacatca acaactgatg aagcaactct gactgatatt ccggttaaag 196801 cgtattatga tgatgaaaat tacgtcgtga cgggtgttcc gcaaacggtt aatgtcacga 196861 taaaaggctc gacaagcgcc gtgaaaaagg ctcggcagac caaaaacttt gaaatatatg 196921 ccgatatgga acatttgaaa accggcacac ataaggttga gcttaaggcc aaaaacgtgt 196981 cggatgggct gacaatctca attaatccgt ctgttacgac agtgaccatt caggaacgga 197041 cgaccaaaag ttttcccgta gaagtggagt actacaacaa aagcaagatg aaaaaaggct 197101 attctccgga gcagccgatt gtcagtccga aaaatgtgca gattaccgga tcgaaaaatg 197161 tgatcgataa tatttctctt gtaaaagctt cagtgaattt ggaaaacgca gatgaaacga 197221 ttgaaaagga agcgaaagtg actgtctatg ataaagacgg aaacgcgctt cctgtcgacg 197281 tggagccctc ggtcatcaag attaccgttc cggtgacaag cccgagtaaa aaagtgccct 197341 ttaaaattga acggacagga agccttcctg acggtgtcag catagcgaat attgaatcca 197401 gccccagtga ggtaacggtt tacggctcac aggatgtgtt ggattctctt gaatttattg 197461 acggcgtcag cctagattta agtaaaatta acaaggattc cgatatcgag gcagatattc 197521 cgcttcctga cggtgtcaaa aaaatctcac cgtcaaaggt gactttgcat atagaagtcg 197581 atagtgaagc ggatcagaag ttcgagaatg tccctatcaa gactgtaggg ctgagcagct 197641 cacaaaacat tgaatttctt gatcctgaat cacaagcgat agatgtaacg gctaaaggct 197701 ctcccacgaa tataaataaa ctgaaaaaat cagatattga attgtatgtg aatgtttcag 197761 atttagagga cggggagcat agcgtgaagc ttgaagtgaa cgggccacag aatgtaactt 197821 ggtccttggg gcggaaaaac gccaaaatca agctgacgtc taagaaaagc aatacatcaa 197881 cgaatgataa cagcagcaat acatcaggga accaggacac agataaacaa acaaatgatc 197941 aaaagaacaa tcagcaagaa gatacaaaga acactgataa aaacaacaac gatcaaaacc 198001 aagacggaaa taaagatcaa aaccaagatc aggatgagga tgaatccact gcgaattcac 198061 aatcctcatc ggaataaaaa aggagcgatt ataaaatggg caagtatttt ggaacagacg 198121 gtgtaagagg tgtcgccaat agtgagctta cacctgagct ggcctttaaa gtcggacgtt 198181 tcggcggtta tgtgctgaca aaagacaaac aacgtccaaa agtgctgata ggccgcgata 198241 cacgcatctc cggccatatg ctggagggag cccttgtcgc cggactttta tccattggcg 198301 cagaagtcat gcgcctgggt gtcatttcta caccaggtgt atcttatttg acaaaagcga 198361 tggatgcaga ggcgggcgtc atgatttccg cttctcataa cccagtgcag gataacggca 198421 tcaaattctt tgggggagat ggatttaagc tttctgatga acaggaggct gaaattgagc 198481 gcctgatgga cgaacctgag gataagctgc caagacctgt cggagcagac cttggacttg 198541 taaacgatta ttttgaaggc ggacaaaaat atctgcaatt cttaaaacag acagctgatg 198601 aagatttcac aggcattcat gtggcattgg actgtgccaa tggcgcaacg tcatccttgg 198661 cgacacacct gtttgctgat ttagatgcag atgtttctac aatggggact tccccgaacg 198721 gattaaacat taatgacggc gtcggttcga ctcatcccga agcgctcagc gcgtttgtca 198781 aagagaaaaa cgcggatctc ggtcttgcgt tcgacggtga cggcgaccgc ctgattgctg 198841 tcgatgaaaa aggaaatatt gtagacggcg accaaatcat gtacatatgc tcaaaacatc 198901 tgaaatcaga gggccgttta aaggatgata cagtggtttc aaccgtgatg agcaacctcg 198961 gcttctataa ggcgctcgaa aaagaaggca tcaaaagcgt gcagacagct gtcggcgacc 199021 gctacgtagt agaagcaatg aaaaaagacg gctacaacgt cggcggagag cagtcaggac 199081 atcttatttt ccttgattac aacacgacag gggacggatt attgtctgct attatgctga 199141 tgaacacttt aaaagcaaca ggcaagccgc tgtcagagct tgcagctgaa atgcagaagt 199201 tcccgcagct gttagtcaat gtgagagtga ctgataaata taaagttgaa gaaaatgaaa 199261 aagtaaaagc agttatttct gaagttgaaa aagaaatgaa cggcgacggc cggattttgg 199321 tgcgcccttc aggaactgaa ccgctcgtcc gtgtcatggc tgaagcgaag acgaaagagc 199381 tgtgcgatga gtatgtcaat cgcattgttg aagtcgtccg gtcagaaatg ggattagagt 199441 aacgaagtct attatcagag agtgaacaag acaagcgagg tttacataag ataattgtga 199501 gacatacggc aaagttgctt aaaaaacaat tgaccgttta tgccacatgt tgtaaaatca 199561 agcttgtctt gttcttattt tctcaatagg aaaagaagac gggattattg ctttacctat 199621 aattatagcg cccgaactaa gcgcccggaa aaaggcttag ttgacgagga tggaggttat 199681 cgaattttcg gcggatgcct cccggctgag tgtgcagatc acagccgtaa ggatttcttc 199741 aaaccaaggg ggtgactcct tgaacaaaga gaaatcacat gatcttccaa aaaacatgta 199801 ggaggggacg attgaaagtc cccttgaaat ttgactttct tcgtctcctt ttacaatctt 199861 aggaggaaga aaaatatgtg tggaatcgta ggttatatcg gtcagcttga tgcgaaggaa 199921 attttattaa aagggttaga gaagcttgag tatcgcggtt atgactctgc tggtattgct 199981 gttgccaacg aacagggaat ccatgtgttc aaagaaaaag gacgcattgc agatcttcgt 200041 gaagttgtgg atgccaatgt agaagcgaaa gccggaattg ggcatactcg ctgggcgaca 200101 cacggcgaac caagctatct gaacgctcac ccgcatcaaa gcgcactggg ccgctttaca 200161 cttgttcaca acggcgtgat cgagaactat gttcagctga agcaagagta tttgcaagat 200221 gtagagctca aaagtgacac cgatacagaa gtagtcgttc aagtaatcga gcaattcgtc 200281 aatggaggac ttgagacaga agaagcgttc cgcaaaacac ttacactgtt aaaaggctct 200341 tatgcaattg ctttattcga taacgacaac agagaaacga tttttgtagc gaaaaacaaa 200401 agccctctat tagtaggtct tggagataca ttcaacgtcg tagcatctga tgcgatggcg 200461 atgcttcaag taaccaacga atacgtagag ctgatggata aagaaatggt tatcgtcact 200521 gatgaccaag ttgtcatcaa aaaccttgat ggtgacgtga ttacacgtgc gtcttatatt 200581 gctgagcttg atgccagtga tatcgaaaaa ggcacgtacc ctcactacat gttgaaagaa 200641 acggatgagc agcctgttgt tatgcgcaaa atcatccaaa cgtatcaaga tgaaaacggc 200701 aagctgtctg tgcctggcga tatcgctgcc gctgtagcgg aagcggaccg catctatatc 200761 attggctgcg gaacaagcta ccatgcagga cttgtcggta aacaatatat tgaaatgtgg 200821 gcaaacgtgc cggttgaagt gcatgtagcg agtgaattct cctacaacat gccgcttctg 200881 tctaagaaac cgctcttcat tttcctttct caaagcggag aaacagcaga cagccgcgcg 200941 gtactcgttc aagtcaaagc gctcggacac aaagccctga caatcacaaa cgtacctgga 201001 tcaacgcttt ctcgtgaagc tgactataca ttgctgcttc atgcaggccc tgagatcgct 201061 gttgcgtcaa cgaaagcata cactgcacaa atcgcagttc tggcggttct tgcttctgtg 201121 gctgctgaca aaaatggcat caatatcgga tttgacctcg tcaaagaact cggtatcgct 201181 gcaaacgcaa tggaagctct atgcgaccag aaagacgaaa tggaaatgat cgctcgtgaa 201241 tacctgactg tatccagaaa tgctttcttc atcggacgcg gccttgacta cttcgtatgt 201301 gtcgaaggcg cactgaagct gaaagagatt tcttacatcc aggcagaagg ttttgccggc 201361 ggtgagctaa agcacggaac gattgccttg atcgaacaag gaacaccagt attcgcactg 201421 gcaactcaag agcatgtaaa cctaagcatc cgcggaaacg tcaaagaagt tgctgctcgc 201481 ggagcaaaca catgcatcat ctcactgaaa ggcctagacg atgcggatga cagattcgta 201541 ttgccggaag taaacccagc gcttgctccg ttggtatctg ttgttccatt gcagctgatc 201601 gcttactatg ctgcactgca tcgcggctgt gatgtggata aacctcgtaa ccttgcgaag 201661 agtgttactg tggagtaata attaattaac ccctttggat aagaaggtct tcacatgtgc 201721 tgctaggctc caaatgtaca cctttccgta agggcaaagt caaatgtgaa aaaaaactgt 201781 tccaaagtta atcagaaatt tattttcata ttgtatcctt cggtatcaag tgaaaggagc 201841 atcatatgaa aacattatgg aaagtcctca aaattgtttt tgtcagcttg gctgctttgg 201901 ttttgcttgt atccgtctcg gtatttattt atcaccattt ccagctaaat aaggaggcgg 201961 cactgctgaa aggtaaaggc acagtagtcg atgttgacgg taaaaagatg aatgtgtatc 202021 aagagggaag cgggaaggat acgtttgtgt ttatgtccgg ttcgggtatt gctgcgcctg 202081 cttatgaaat gaaggggctg tacagcaagt tttcaaaaga aaataagatt gctgttgtag 202141 atcgggcagg ttatggatac agtgaagtgt ctcacgatga cagagatatt gatacggtat 202201 tggaacagac gaggaaagcg cttatgaaaa gcggaaataa gcctccttat attttaatgc 202261 ctcattcgat atccgggatt gaagcgatgt attgggcaca gaaatatcct aaggaaatca 202321 aggccattat tgcgatggat attggattgc cccagcagta cgtcacgtat aaattgagcg 202381 gagttgaccg attgaaagtg agagggttcc acctgttaac ctcgattggt tttcatcggt 202441 ttataccttc cgctgtatat aatcctgagg tgattcgaca gtcgttttta actgatgaag 202501 aaaaagaaat ctataaagcc attaacttta agcaattttt taatgcagat atggagcatg 202561 agcttttaca gtcttaccaa aacggcagca aatctgtgaa tctgcctgcg ccaaaggaaa 202621 ctcccgtctt gattttagat gcagtctctg accaaaatag acattcaaag tatgctatac 202681 aaaaccgaaa agactatgaa gcgtttgcgg ctcaattcaa tactgccgat ataaaggaac 202741 tgaggggaac acacagtatt tatttatatc agcctgatca aatatataaa ctgtccatgg 202801 agtttatgag aaaggttcgc taggatgaag ggttatcgta ttttaatcgt tgaggacgat 202861 gtgatgattg gtgatttgct gcaaaagatt ttgcagcgcg agggatatcg tgtgatatgg 202921 aaaacagatg gagcggatgt gctttcggtg attcagaagg tggatttggt cattatggat 202981 gtgatgctgc cgggtgaaga cgggtatcaa atgtctgcaa aaatcaaaaa gctggggctg 203041 ggcattccgg ttatttttct ctcagcccgc aatgacatgg acagcaagct tcaaggtttg 203101 cagatcggcg aggattatat ggtaaagccc tttgatccga gagagctgct attaagaatg 203161 cggaatatgc ttgagcatca ttatgggacc tttacgcaaa tcaaacattt gtatattgat 203221 gcggtaacga aaaaagtgtt caatgaaagc ctgcatgatg aggtattatt tactgcgatt 203281 gagcggaaaa ttttctttta tttatatgaa aatagagaca gtatcctgac aaaggaacat 203341 ttctttgaat atctatggca gctcgaagat agaaacccga atattgtcaa tgtgcatatt 203401 aaaaaaatta gagctaaaat caatgatcaa gcgggtgaga tgattgaaaa tatatatgga 203461 gaagggtatc ggctgaatac cgttgtgaag aaatgaagct caagacaaaa tatcagttgt 203521 tattgtttac ggccgtcatt agtgttccga tgctattgct ggcggtcagt gttttgatgt 203581 cggtgattta tgacagcatg tttaaaccga tgaatcatgg tatgcccttt cacaggtcgt 203641 ttgcataccc ggcaatgatc gttgtatttt tgatatcact cttattgtta gcttttttat 203701 tttcaaagtc gattcattct ctgttgcata aaatcaatct attaaatcaa accattcggc 203761 atttggcgag tgatcaaagg gtgcccgata aaattgaagt gaagcgtgct gatgaaatcg 203821 gggaactgat caagtcggtc aatttgttaa ttgaacggac gacatatcgt gaactggagc 203881 tgagacagca ggaggaaatc aaaaaggagc ttttgcaaaa actgcggcat gacattaata 203941 cacctttaac ggctctcagg ctgcagttat tttatttgga agaccaatgt catggtcagg 204001 ctgtattcga atcattgtat cagcaaatcg aatatatctc ggaattaact aatgaattca 204061 atctatattc cgctgagacg ctggaaagct cttatattgt aaatgaagaa gtgcgtctaa 204121 acgagctatt agaaacagcg gtgaaaaagt gggattattt atacagtatg agtgggattg 204181 agctgcacta taagccggca gatcaagatg tgatatggat gagcaacacg ttatggatgg 204241 aaaggctgtt tgataatatt tttcaaaata cgttaaggca ttcaaaagct aaaaagatgg 204301 aagtcacgat tgaacatggc gatgttttta ttcgtgatga cggtattgga tttgatcgga 204361 atgagagcag tgagggactt gggttaaaga ttattgagga tacatgcagg ctgcttgcga 204421 ttacttatga gctgcataca aatgataacg gaacggggtt cttgttttca aaagagtgac 204481 cccgctgatg tttttctttc tcctataaaa tttatataat agggagaaag aaatggggtg 204541 aacatcatat gtttaaaaaa atcatcaaaa cgattaagta cctctcaagc agttctagtg 204601 accgatatcg cagacaccgg cattacagca gcagccggcg cagacattat cgcagctaca 204661 gcagcagttc gggcaaaaga agacactacg accgttatgg cggcagtcat cgttacaaac 204721 gccggagcta cagcagcagt taatccaaaa aaagttcttg ttccgctttt gggacaaggg 204781 tttttttatg tgaccgattg aatggcccgg tttagatcct cgcgaatgga agcggtgtgc 204841 tgatactctt cctcaatgcc caataatctt ttcagcagca aggttacttc ctttgtcagt 204901 gttaattcct ccagccaagt gccgtttttc ttcttttttc ctttatattg agagtacagc 204961 aagaataaca gcgtttctcc gagatcgaag aagtcatcct gttttcgtac ctttatttcc 205021 tccatttctt caggagtcaa ttgtttggca aggccgaaat cgatgaggca gagcctgcca 205081 tcattgatga tgatattagg cgttctgatg tcgctgtgga agataaggcg atcatgcagg 205141 tattctataa tctcaagcag ctgcgaaatc agttgtaacg ccataagctc tgtgaacggc 205201 tgttttcgaa aaaataataa ttcttctata ttctctccct caatgaactg catgacataa 205261 taagcctgtc cgtctatgat gaattcatct atgaagcccg gaatttgcgg gtggtgaatg 205321 tttttgagca gttttatttc ctgctggaat cggactttct ctttttcctt tttggctttt 205381 gtcggccgaa gctgttttaa gacataaggt gtttgagcta ggatatcggt gcacaaataa 205441 accaaaccgt agcctcccat accgaggcac tcttcgattt tgtattgatg atttaagata 205501 acgccgttct ttagagggcg gtcaaatagc agttttttta gaagttttaa tgccatgtct 205561 gcacttccct tggttgtact gactatagtt taccttctag acggagaata aaaaagagcc 205621 ggataaccgg ctcggtataa gttaaaactg ctttgtcacg tcgtattcat aatctatttt 205681 tgcttttacg ttgctcatcg tcgatctggc tgtcgctaat gtattatatt taaaactcca 205741 tacctttgcc acactgagtt gatccgacaa agagatatca taagaccctg aagtcgagct 205801 gtttacaagg gcacggctcc attcgttatt ttcgcttgtc atgatcagat ggcgtgtatt 205861 tccctggctt ggtgtttgag tggcggttgt ttgaactctg gttacaatgg catcacgcgg 205921 tatcccagat tggtttgtta aatcaacctt gatcacgctg gagtcagaac ctgaggggct 205981 aaggcttgta tttcctttat tttcagcaac gccgctgaat tggaacgttc cgctgcctga 206041 tttgattcgg tcttcaattg aaagcgtaaa gtacatgttt ccagtatagg tgcctcgtga 206101 cactttcaca tagaaggtat ccgtcgtgtt ttgggcgtct gcatttgcat aaataaaaga 206161 agaaaacgta ttagggttaa taacttctgt cccttgagaa acaggtattc tgttcttgtc 206221 ataaatttca attttcatcc ctgtatacgc gctctggtat gtactcctca tgtatacttt 206281 ttctccctta ttagccgtaa aagtgaaata ggcttcatct tgaccagctt ccagtattgt 206341 tgtatcgata tttttatatt tccaataacc gatcggcatt gcggtatcaa atgaattgtt 206401 tcctgtgata gcagtgactc cgacagctga tgccgaatac gtaaaggtag ataagacaga 206461 aagcataaca gcgaattgaa taagccattt tttcaccatg caaacaacct ccttttattt 206521 ccatcataca taataacgat ttaggtgtaa ataaatgttt tttgaggtta atatatacat 206581 tatattcgcc gataaaaaag aataagagag aatactcggg agggaattca atgcgtctga 206641 atcggcaatt tatccgcact cagctgattg cacagaacat attgagcaag aatgcgcctg 206701 ccaaacggga gaatgcgact gaaaatccag cggcagttct ggaaaaggca tatagcaggc 206761 ttaagtcaca atcttcaact gggggaatca atcagttcaa ttattctaaa accagcgtgt 206821 cgggaaacag cgggacgttc agcaaagtgt atcaatcagc gaatgatcga acagtgacag 206881 acacagggga agaaacagtg attcaatccc aaaaccccta tgaatctgag agtgatatca 206941 gaatcaaaat actagatgaa aaatacagca ggatgaatgc gattaataaa acaaagtctg 207001 atccattagg ctatattaag gataagtacc aaaattcaaa gtctccttat ttcagaagtg 207061 atctgtcagc tgcagaaaga caggccgctt acgataatga aacagaatgg ttattcaaag 207121 ggaaggcgca aaactataac cttcaggatg ctgtgtttcg gaatgtcaca tttcatgggg 207181 aagtggaagc tgagaatgaa aaggtgtatc agcggggaca ggttaaccag cagctgcaag 207241 tactgttgaa tcgaaaccat attcatattc cagaggggac agagctgacg tttacaatca 207301 caccgattga ctatcaggtg cgggtaagcg ggacagacga tcaggatctg atcaagcaaa 207361 ttgagcaagt gctgcaatct ggagacaaca gcaaagaact atttttacac atcatgaaaa 207421 gtcaaagcag tgattcagca caattttccg aagaggccta taaaaagtat caggcagctc 207481 gtgagatgta tgaagttaca ggctaccatt tgaaggattt agaagtgatt gatgggcggt 207541 acgtcacgcc tgagggacgt gacttaatgg atgtatataa ggaagagctt gaaaaagatc 207601 cagtgcagaa acaaacggct tcttatgcta tatcttacta tcgttcagag ctcagtaaaa 207661 tcgcggaagc cgggtataat gccattccgg atttcatcct atcaattgat tacagcaatg 207721 gatctctgag agatgtggga caaagcaaga gctatgggac cggagatacc gggtggcttg 207781 aagcattaaa gcgtcaaacg ggtgtgaatt attaggtaag ctgttcatgt aggacagctt 207841 attttttatg agaatctaag gggtgaatta atcccaatat tcaaataatt ttattatttt 207901 tatataaaag attttaaaag aagtgaacga ttcaaaactc tgaacaaagg tgtttacctg 207961 aaaaaaacaa ttgtattttc cagagaaatt tattatgatg aaataagtaa tttaggagat 208021 tatataacaa ttttaagttt gaattttctg attgttatca ctgattcatg tgaaggcaag 208081 caggtctgct gttttctcat ttatgagtat tttgttagga ggaggaagag gagtggcaaa 208141 taaagaatta aagaggggcc tgggcgcgcg ccatattcag atgatcgcct tgggcggtac 208201 aatcggtgtt ggcttgttta tgggttctgc cagcacgatt tcatggactg gcccatctgt 208261 ccttctggct tatgcaatat gcggaatttt tatctttttt attatgcgtg cgatgggtga 208321 aatgctgtat gtcgagccga gcacaggttc ttttgcgacg ttcggccatc aatatattca 208381 tccgatggca ggttatataa cagcatggag caactggttc cagtggatta tcgtcggcat 208441 gtcagaaatt atcgctgtcg gttcttatac gaagtattgg ttcccggatt tgcctgcttg 208501 gatacctggt atcgtggcaa tggtgattct tggtgcggcg aatttaattt ctgttaagtc 208561 gtttggggaa tttgagtttt ggtttgcgat gattaaaatc gtgacgatta tcttgatgat 208621 tattgcggga atcggaatta ttttcttcgg ttttggcaat ggcggagatg cgatcggttt 208681 gtcgaacctg tggtctcacg ggggcttctt tgcaggaggt ttctcaggtt tcttctttgc 208741 actgtctctt gtcattgcag cctatcaagg agttgagctg atcgggatta cagcgggtga 208801 agcgaaggac ccgcaaaaca cgctaagaaa tgcgattcaa agtattatct ggcgtatttt 208861 gattttctac attggcgcta tttttgtgat cgtgacggtg tatccttggg atgagctcaa 208921 ctcactcgga agtccgtttg tgtctacgtt ctcgaaaatt ggaattacgg cagcggccgg 208981 cattattaac tttgtcgtga ttactgcggc aatgtccggc tgtaacagcg gtattttcag 209041 cgcgggccgc atgctgtata cactgggtgt caatggacaa gcaccgaaat tctttaagaa 209101 gatttcacgc aatggtgtgc cgctgtatgg cacaattgcg gtgctgatcg gtttggctgt 209161 cggcgttgta ctgaactata tcgcgccgcc gaagatcttt gtctatgtat acagcgcaag 209221 cgtgctccca gggatgattc cttggtttat cattttgatc agccatatcg gattcagaaa 209281 agcgaagggt gctgcattag ataaacatcc attcaaaatg ccgtttgctc cttttacaaa 209341 ctatttgacg attgctttct tgctgatggt tctggttggc atgtggttta acgatgatac 209401 tcgtatctcc ctgattgtag gcgtgatttt cttagcgctt gtggtcatta gttattatgt 209461 gtttgggatt ggcaaacgca cgcaggccaa tttgacaaaa agcgaacaag cagctgaata 209521 acgataaaaa agagacattc acggatgtct ctttttttat ttttcgcgta tggattttcc 209581 ctattttagc aagctatagg gtaaagatag cagaaggaaa ggtgttcata aaatggatgt 209641 tacactcggt tatttgcgcg aatcactttc gaatcatcta gaaaatgaag tctgccagcg 209701 tatttgcaag aagatgctgg cgaagcgtta tgcaaatgaa gaggaatttg taaaagactt 209761 agatgataat gaaatgtctt ttttgaacca tgtattagaa aaagaaatta agtatgccca 209821 gaatgaacag gatcaaaaac gggccaagga attaaacgag gtgtatgaat tactgctttg 209881 agaaaggcgg gtaagaaatg ggagcaattg aacgaagcgg atatacattt cagccggagt 209941 ttagcgttgt ccgtcaaaac ggagccatcc atgtgtacca tcaaggagaa tttgtggaag 210001 aaatcgaatt tgaatttaac ggggaatatc ccgatcatga tttgattgaa gagcttgtga 210061 atcattattg ttttgagcat gagatttaga gccctgccgt gcagggctct tttatttagg 210121 atgtaatcag gccatacttt ttcaggatat ccacggtgat gtttttggct tttgtgccgg 210181 aatcatcgac attggtgaca aagacataag agccatgctc tgttttgatg aatccgacaa 210241 accatcctaa tcccatatca gtcaggcggg ttccggtttt cccgtagagc gtgtaatgat 210301 cgccttcctc ttgaatcatc atgcgcttga cgattttcat caccggcttg tcaaatggaa 210361 gctcctcttt agccagtttc tccaaaaaag tttcttgttc cagcggagat attgtgagcg 210421 agctttgcag ccaaaactgg tcgattcccc cgctgatatc ctcgttgccg taagatagag 210481 tatgaagcca tgttttcatt ctttcctcgc cgatatctct cgctaatgcc tgataatacc 210541 agattgcgga ttcgcgcatg gccgagccaa gcgtatggtc gcggttccat gattcgaatt 210601 cacgcttgac cccgtcccat cgtttaacat cgtattcatc tcttacagct ttgacctgca 210661 aaccgattaa agcgttcacg actttaaagg tggattgcgg agtttgtctt tgatttgccc 210721 gttttctgtt atagacaaat gtctgatcct tttgtaaatc gtgaagaatg aaggttccat 210781 ccgtatcctt gaattcatca tcgacattca ttttgctgac attcaagtgt ttttcatgag 210841 cagatgatgc tgcgtggacg gagaagccgc cgatccctgc aatactcagc acaagcacaa 210901 catatatcca ttttttcatt ttgttctccc cttcgttttg attaactacc ttttctctct 210961 ttcgtttgtt cttcctttaa aaaataatca aaaagcgctt aaatttggtt ttgcaaacaa 211021 atactgttac tgggtttata gtcggaagat aacgtgaaaa tagagggtaa aaaggaaggc 211081 agggtaagcg gatgaatgag cagattccac atgacaaaag tctcgataac agtctgacac 211141 tgctgaagga agggtattta tttattaaaa acagaacaga gcgctacaat tcagatctgt 211201 ttcaggcccg tttgttggga aaaaacttta tttgcatgac tggcgctgag gcggcgaagg 211261 tgttttatga tacggatcga ttccagcggc agaacgcttt gcctaagcgg gtgcagaaat 211321 cgctgtttgg tgttaatgcg attcagggaa tggatggcag cgcgcatatc catcggaaga 211381 tgctttttct gtcattgatg acaccgccgc atcaaaaacg tttggctgag ttgatgacag 211441 aggagtggaa agcagcagtc acaagatggg agaaggcaga tgaggttgtg ttatttgaag 211501 aagcaaaaga aatcctgtgc cgggtagcgt gctattgggc aggtgttccg ttgaaggaaa 211561 cggaagtcaa agagagagcg gatgacttca ttgacatggt cgacgcgttc ggtgctgtgg 211621 gaccgcggca ttggaaagga agaagagcaa ggccgcgtgc ggaagagtgg attgaagtca 211681 tgattgaaga tgctcgtgcc ggcttgctga aaacgacttc cggaacagcg ctgcatgaaa 211741 tggcttttca cacacaagaa gatggaagcc agctggattc ccgcatggca gccattgagc 211801 tgattaatgt actgcggcct attgtcgcca tttcttactt tctggtgttt tcagctttgg 211861 cgcttcatga gcatccgaag tataaggaat ggctgcggtc tggaaacagc cgggaaagag 211921 aaatgtttgt gcaggaggtc cgcagatatt atccgttcgg cccgttttta ggggcgcttg 211981 tcaaaaaaga ttttgtatgg aataactgtg agtttaagaa gggcacatcg gtgctgcttg 212041 atttatatgg aacgaaccac gaccctcgtc tatgggatca tcccgatgaa ttccggccgg 212101 aacgatttgc ggagcgggaa gaaaatctgt ttgatatgat tcctcaaggc ggggggcacg 212161 ccgagaaagg ccaccgctgt ccaggggaag gcattacaat tgaagtcatg aaagcgagcc 212221 tggatttcct cgtccatcag attgaatacg atgttccgga acaatcactg cattacagtc 212281 tcgccagaat gccatcattg cctgaaagcg gcttcgtaat gagcggaatc agacgaaaaa 212341 gttaaattaa aaagctctct tcctttatcg aagagagctt tttgattact tctttttttc 212401 atcgtagtat tggacgggat acatggagcc ttctgatacc attttgttgt cctcgatatc 212461 ttgcgggtcc gggtggccgg ctttatcaac tgggaacgtt tccatgtctg gctgttttgt 212521 tattttcatc ttcatgctgt gaatgaattc tcttgccttt tggcgatttg acgggtcttt 212581 taatagataa gaagtgatgc cgacagttga aacagcgaga cctgaaagta acagcttttg 212641 tttcatggtg atactccttt ctattttaag aatagtgttt cctgtatcat tcccgttttg 212701 gaaattgcta aacctgttgt gtttttatca ttggaattaa cagtaaattc catttaagaa 212761 gaaactagtg acttcattcc tgtattggaa ggtaatatac attgacttat tatagatttc 212821 agtcaaaatt cgataaatat tgacaaagta aagtaatcag aataataata taattagcaa 212881 gagaatgtca tcatacatga aaggtgttta cgatatgaat caattgcatc gaagaatggg 212941 aacgttttcc ctcatgatgg tcgggctcgg gtcgatgatc ggttcaggct ggctgttcgg 213001 ggcttggcgt gcggctcaaa tagcaggacc agctgctatt atttcatggg ttattggaat 213061 ggtcgtcatt ttatttattg ctctttctta tagtgaacta ggttctatgt tccctgaagc 213121 ggggggaatg gtcaaataca cgcaatattc acacggttcg tttatcggtt ttattgcggg 213181 ctgggccaac tggattgcga ttgtgtccgt cattccggtt gaagcggtgg cctccgttca 213241 atatatgagt tcttggcctt gggaatgggc gaaatggaca agcggtttgg tgaagaatgg 213301 aacgctgact ggggaaggac tagcgtttgc ctctgtattg cttctcattt attttctgct 213361 gaactactgg acagtcaatc tattttcgaa agcgaattca ttaattacga tttttaaaat 213421 tattattccg ggtcttacga ttggagcttt gctgtttgtc ggattccacg gagaaaactt 213481 tactggcggt caaagcattg cgccgaatgg ctgggcaagt gtgctgacgg cggttgccac 213541 ttccggtatc gtttttgcgt ttaatggttt ccaaagcccg attaatatgg cgggtgaagc 213601 aaaaaatccg gggaaatcaa tcccgattgc ggttgttggc tctctttttg ttgcgacagt 213661 gatttatgtc ctgctgcaga tcgccttcat tggagctgtg aatccttctg atattgctca 213721 cggctggagc catctgaatt ttaattctcc ttttgctgat ctggcgattg cgctgaatat 213781 taactggctt gttattgtgt tatatgcaga tgcatttgta tcaccgtctg gaacggggat 213841 tacgtatacg gcgacaacgt cccgaatgat ttacggaatg gaaaaaaaca aatacatgcc 213901 gagtatattc gggaagcttc atccgattta cggcgttccg cgacaagcaa tgttctttaa 213961 cttgattgtt tcgttcatct ttttgttcct gttcagagga tggggcgtat tagcggaaat 214021 tatttctgtt gctacgttaa tttcttatat caccggcccg atcacagtga tgacattgag 214081 acggacgggg aaagacctgt acaggcctct tcgtttaaaa ggcttaaatg tgattgctcc 214141 gcttggattt atctttgcgt cactggtgct gtattgggcg cgctggccgt taacaggaca 214201 ggttctgttt attatcctga tcggtcttcc gatttatttc tattatcagg cgaaggcgaa 214261 atggaaaggg tttggccgga actttaaagc cggcgtctgg atggtgtttt atctgctggc 214321 catgatggtt atttcttatt tgggcagtga taaattcggc ggcctgaatg tcattcatta 214381 tggctgggat atggttctga ttgcgatggt atcccttgta ttctatgtgt gggcgctgaa 214441 gagcggctac cagacagaat acttaaagga tgcgaaagag ataaattctc agctgcttaa 214501 tggacagtca gaagctgctg ccggaaaaga ataaaatata gaagaaaacc ttgcgatagt 214561 tgtcgcaagg ttttttgctt ttaataaccc ttttttactt tgtggaaaag atcaggatag 214621 ttggtgaaca ctcctgttac gccccaatca agcaggcgat gcatatcagc ttcattattg 214681 actgtgtaag gatgaagcag gaggccgtgg ctgcggatca tacggacgtt ttcttgattt 214741 aaagctttat aatccgggcc cgcaccgaca gcgtatgttt tgatttcttc cagggcagca 214801 tctgtcattg acgccatttg tttggcttcc agcaattgaa cggtcggcag gtttggctgt 214861 aattgatgga cttttaccag gctttctttg ctgaacgatt gaatgatcac ctggcctggc 214921 ttagaatgct ttcccagtaa tttatgtttc tgcaaagaag cgatcagttt ttcttccata 214981 cctgggtagg tgtcaggcga ttttgtttca atgtagtagt tcgcgtgctt tccgaaacgg 215041 tctaatacct cttctaatgt aggaacttta aggccgacgt actgcggctt tgctttttcc 215101 ggataggctt cattaaacca agaaccggcg tcaagcttct taatgtctgc gagcgtatgg 215161 tctttcaccc aacccattcc gtttgtggtg cggtccagtt tttcgtcatg catgacaatc 215221 aattttccgt cttttgtcat ttgcagatcc aattcaataa aatcagcttt cattttctga 215281 gcggtttcgt aagacagaat cgtgtgctca ggcacatatc cagaagcccc tctgtgcgcg 215341 acggtcagga tacggtcagg tgacagcagg tttccttttg acgctgccga cactggcgtt 215401 accataaatg agagtaagcc cagcgacaga acaaacaagg ccagtattct attttttctc 215461 atgatttctc ctccttatag ataagcacta cctgtctttc ataataaaaa acggatgtaa 215521 acggcgtgtt ggaaaactat taatctttta tgtgtctttc ttaaacatgc tctgcccgtt 215581 ttcctgtatt ccacgtcaaa gccaagaaga cgatggcaag aatgcaggat gagatcagca 215641 tgataaagcc gccgttccag ttaaaacggt ccacgacaaa gcccataatg gcgtttgcga 215701 aggcggatcc gccgatgtat ccgaaaaatc cggtcaaacc ggctgcagtt ccggctgctt 215761 ttttcggtgc taggtcaatt gcttgaaggc cgatcagcat aacaggtccg tagattaaga 215821 agccaatgct gatcagggcg atattgtcca cgagcggatt gccggccgga ttcagccagt 215881 acaccaatac ggcaatgaaa acacccgcca taaacaaaac gcctgccggt gcccggcggc 215941 ttttgaagaa tcggtcactg atccagccgc acaagatcgt tcccggtatg cctgcgtatt 216001 cgtaaagaaa atacgaccag cgtgagtctt caggagaaaa gcctttggct tctgttaagt 216061 aagtaggcgc ccagtcaacc acgccgtatc gcacgaaata aacaaataca ttggcaaaag 216121 cgatgtacca aagaaatttg ttgttcagca catattgaaa aagaatttct tttgttgtta 216181 attctttttc ctgattttta aaagcgtgtt ttggatagtc attccgatac tcttcaattg 216241 gcgggagtcc gcaggattga ggcgtatcac gaaccaataa aacaattaaa aatgaaatga 216301 taatggcgat gatggcaggg aagaaaaaca cgcttttcca agtgacgaac atcgcgatcc 216361 caagagtgac aagcggagca agaataccgc cgcctatgtt atgggcgaca ttccagatcg 216421 acatttttgt gccgcgttca cttatggaga accaatgggc catcgtcctg ccgcatggcg 216481 gccagcccat tccttgaaac catccgttga taaacataaa aataaacatg atggtgacgc 216541 tcgaagtcac ccaaggcatt gaaacgaata gaatattaac gattgctgat aaaaataggc 216601 ctgtcgccag aaaatatctc ggattacagc ggtcagacac cattcccatg atgaatttgc 216661 tgaagccgta cgcaatggac acagcggcca gcaccaaacc cagttctgtt ttcgaaaatc 216721 cctgttcctg cagataagga atggcaaagg caaagttttt ccgcagcagg tagtagcctg 216781 cgtagccaat gaaaatacca atgaatactt gcagtctgag ccgtttgtat gccgcatcca 216841 tctttgaatc atccagtctc tcaatatgag gagccggttt aaatatatta agcattaata 216901 attatccccc tttgctgttt gtgctggatg tgtggcgtgc ctcctttccc gaaaaacaaa 216961 aagagccaga aaacacccct tgtcaaaagg ggttggattc ctggctctcc tcatctccat 217021 ccaagctatt aacttatcat gatagcgctt tcttaaatta tcatagtccg gagcgaatgt 217081 aaacgggtaa ttttcaaatt gggccttagg gaagtgaata ttatcctttt actaaatgca 217141 attatatttt tttactagta acataaaaat ctggagggag gctgtttaaa gatggatgaa 217201 ttagatatcg cattctttat tttaccgtta ggaattatgc tgctatcgat tgtcgggacc 217261 tgtatttgta aaaacccgta tctgatgcca atgcttagtt tggtgatttc tcttgtgctc 217321 acctttacca tttttaatca atcatttttg ggatgggctg ttgtctatag cttggtttct 217381 ctggctttat cctatatcac attgattgtg gtaaggaaaa ggaaggaatc aggaaattaa 217441 aaagacctca ctttctaaca tatcgttgac taaagcaact atatgtgatt ataattgctt 217501 tagtcaacga tattagaaag tgggaattga tttgaaaaca agagaatcat ctgtcgggtt 217561 aaaattcaga aagttcaatc gattttatac aaacgtcctt ggtttcctta atgagcacat 217621 ttacgacagc ccgttttcct taacagaaac acggatttta tttgagattt ataatacgcc 217681 taattgtacg gcaaaagctc ttcaggataa gctggggctt gaccggggat atgtcagcag 217741 gattgtgaag cagtttgaaa aagaagattt gatttataaa cagaggagca aagatgacgc 217801 ccgccaccat tacatttttg tcacagaaac aggaaaaacg atttataaaa agctggagga 217861 gaaagccaac gaacaagtag aactgatgct gaaggtaatc aaccaaaagg agcagcacaa 217921 gcttgccgag gcgatggcag agattgaagc gatcctttca cagtcgcttt ctgccagagc 217981 atcagagata tcgattagag attattttct ttcggaggat cttcaactcc ttattgagaa 218041 acaaagacaa ttttacgcgg aggctcacgg ttgggatgac acgtttttag cttatcttca 218101 ggagacattt gacgctgaca tcgaaaaaat atggattgcg gaaagcggcg ggaaatttgc 218161 cggctctgtc gggttggtca agcacgatga aaagacagtc cagctcagat ggtttctggt 218221 tgatgcggat tttcggggca gggggcttgg cacgcaattg ctggagcatc tggttgcata 218281 ctgccaagac atgaagtttg accgcatttt cctttggacg gtgagcacga tggctgaggc 218341 tcgtccgctc tataaaaaat ttggattcag gataagtgaa gtaaaacaag aagcgccatt 218401 atggggacag cagctgacag aagaacggtg ggatttggag ctgtcatgaa aagactgcat 218461 tatgcgtgga tcatcgtctc cgtcaccttt ttgatcttat tggcggttca gggggtgcgg 218521 ctgtcgtttg gtgcgtttgt ggagccgtgg gaacggcagt tttcaatcga tagaagcacc 218581 atctcgctga tttcgacggt gagttttatt gtttatggca tatcacagcc tgtgatcggt 218641 cggcttgtgg acaaatgggg tgcccgggct gttttggcat ggagtgcgtt actgacagga 218701 gtcagcattt tcttaacata ccttgtgact tcgccttggc agctgttttt gctttacggg 218761 ctgggtgtct cgcttggagt gggcggagca tcgaatgtgg cggcaagtgt attggtcgtc 218821 aattggttca gcaaaaagcg gggactagcc tttgggatca tggaagcagg ctttggcgcg 218881 gggcaaatgc ttctcgttcc cggctcactc atgttgatcc attggtttag ctggaagctg 218941 acggttgtgg tgttgggact gctgttaatc gtgattgtct ttccggctgc gctgctgatg 219001 ctgcggaaca atccttcaga aaagaataca gagccgatag gcggactggc tgcatcagaa 219061 aaagaaacag cacccaaaac aacagctctt tcagtggccg ggatgtttcg tatgaggcaa 219121 ttctggttct tgatttttcc gtttttgatc tgtggattta cgaccgtggg gctgatggat 219181 acccatttga ttccgttttc tcatgatcat ggcttttcaa cgacagtcac gagtgctgct 219241 gtcagtctgc tagcaggctt taatattgct gggatcttgc tgtccggaat tgtagcggac 219301 cggtggagca gccggaaaat cctgtgcatt ttatatgcgg tgcgggcgct gtcgatcgtg 219361 attcttattt acagccacga gccctacttg cttttagcct ttgcgattct gtttggatta 219421 gtggactttg caacggtagc accgactcaa atgctcgcca cccagtactt tcaaaactac 219481 tcgatcggcc tcatgattgg ctggctgtca ctcgcccatc agatcggatc ggcactaggt 219541 gcgtatgtgc ccggcgtcat ctacacggta acgggtgagt atacactggc tttttatttg 219601 tcgattggaa tgctcgtgct tgcgagcgta atgaatgtga tgctgaggga gccagctgcg 219661 gttacgcgtg acagtgcggc tgtggtagac aagtgatgag gacaaaggga aagcatctct 219721 gatttcgaga ttattcagag atgctttttt tgtatttttg ttctaatacg aagtcgatca 219781 taccgactat gcgggcgttt tcggattttt gtttgaagcg ttcagaaatt tgaacttttc 219841 ttgaaaatgg ggaaacaata aaaacccaaa aaaggccgat caaggcaaaa aacatttgta 219901 cagctaattc tattaattca ttaaaacgag tgctgaaaaa atagaagtat aacgttatta 219961 atgtcacagt acatacgatt ttggcaagtg tgtttgaatg taagcaatgg ttcactaaag 220021 aataccttta attgattcag catgattgaa tcatatttgt ttaggaaaat aagaagttct 220081 ttatcatctt ttttatgttc taaaataaag ttgctgtttc tgtttcttta tatgtatggt 220141 ggtctacatt caatatatac atctcttaaa gtataaaaat tgagtatttc ttagtaagga 220201 tgaaacaaaa ttacatgatt tttttgttat atctttcagt tagaataaaa tctataactc 220261 ctctcattcg caaatattcg gctctctgtg caaagtgcag aacagtatgt aattgtcctt 220321 ttctagatat atttaaaagc tttatcaaat caataaggat tttcaagaaa ataattaata 220381 atagaaagat aaaaatgtgt ggtatgtcaa tgtaattgat ttgtcctgaa aataaagaag 220441 ttgcatagac aacaataata cttccgcaaa acatcaaact catataatgt ggaagggaaa 220501 atggacgagt tgaaaaatat gcttttaatt ggcttagcat agcattatct cttgtatcta 220561 agtagcccaa aagctcttta tcatttttac taattgtaag aacatgattc aatacagcac 220621 taaaattcat tgaatcttca ttatcagagg cagtatgttt attagcctgt atgttttgtt 220681 gatccatttt atatttttta taaagtattg tattaattaa cttgtttttc tcatagaatt 220741 cagatcgttg attaagggat gcttttcctt tgtttttatt tccttttttt atgattttag 220801 tataagtcat aaaaatacaa atgactgtaa aaatagaaaa cactgcaggt gaaatatctg 220861 aaagaatagt attggtgaag acttcttttg cttggatgaa aaggaaagaa gctaaagtca 220921 tagatataaa catgcataaa actgctactt tcacaagaaa ctgaagcgga agagaaggtt 220981 ccgaataata gtgcttcaac tggttgagtg tcagagaatc ttggcgaaaa agataatcta 221041 ttatctcctg ctgattttgc atctgattga tatcatgagc gatgtttttt gttttttcaa 221101 aaactatttg atcatttttc atttttgata aacctccaaa agacgataga taaactaaaa 221161 aaactgcatg agcatatttt aacttatgtt catgcagttt tgtattaaag ttagctagta 221221 taataagcaa aaatggccag taacatagca gataatgcgg tagcgacttt gactccttta 221281 ttgttcgtta aatcactgcc catattccca attagtaaaa gtgcagcaac acctacaaca 221341 gggaataaat attgatcata agacggccaa tctaacgcta attcactctc gggagacgta 221401 actggtactc ccttgtacgt ctttatttta aacgtaatcg tagtcgttag tccagttgtg 221461 acattgtcac cgactggaat atcaggtgta tagattttaa tttgaatgtt taaagattca 221521 gctgttggat ttacataaac ctccaaataa ccgttgcgta ctgataagct cagactattt 221581 aaaaggtttt gataagagtc gatttgtgac gcagtgagag acgtttgagt gtcgcccaat 221641 aaacccgtga tataggcacc tggtttacca tttgtaatgg taattgtgtt tggtgaacct 221701 tcacttggta tggttgccag aagtgaagtt gatagaataa tatccaactc aggtgatgtg 221761 aaaatggttt ctgtcgtatc aaattcaaac atcgcgtttg ccagacttgt tagattttct 221821 aaagctggaa tggtagataa aatgtctgtc agtgtacgca gtcttgcatc atataccgga 221881 tcagacggcg gatttacatt gcttgcacct gagtctcttc ctgaataccc gtctttatca 221941 atcccgatgc ttccagagcc gcttccgatg gttccttcat aaaattgatc aaaggcccag 222001 ttgtttggca tcggatagcc gagattgccg ctaaatcctg ttgacatatt tgccacaaaa 222061 ctatactttg tcagtcctgc ttcagatgta cggatacaaa tgtttcttgg tccgtaaacc 222121 cctatttcat acttaggtgc ggttgaaaat gtctgcattt ttgtaaatgc tgacttaatc 222181 tcttggaaat aaggaatgat tttatcggtc acttcataat cgtatgcatc aaaatcgaca 222241 gcgaaataaa tggtcgtgcc tgacggaaaa cctaatcttc tagcagcaga agcggcacta 222301 tatgcatctc ttgtgccttg gtctttgaca aaataagaag attcatagcc gccgtcttga 222361 taaattggga aaaccttcaa tccggcatca agaataactg caagctcttt agatgtcagg 222421 gctttagatg tgaggccgct gcttgtccgc acatttccgg tcaaatatct gccaaccgtt 222481 ttataaccgt tattccgcag tgtttgagct ttttctgcgg ttataattgt agcagtgtca 222541 caagcagaag cggtgcgagt tgtgtctcct gagcttgata ataaagcttt aatggttggc 222601 atatctgcat aacctgtttg cggcaggcac atgaactctt gaaatgcttt aacagctgaa 222661 acaacaccca caccatattt gccgtcaaac tcaccaggat cgaacgattt tccgttacaa 222721 tagagggcgt actgaacaat taagacaaat cctgttcttg aatcgccggg agttaaagta 222781 gggcacaaac ttgtggtgcc gtttccgaaa aatccattgg caacacttgt gctcatgcct 222841 tcttcttttt gcagggcata aataagagct ttatttgtat cgcggccata cagtccgtca 222901 caaggcatta acccgatata gtcattgtag tctcgattta agttttgttg aatctggcga 222961 attcttgaat cacccccaga caccagctta aaagcgctca tgtctaataa ggctttcata 223021 attaacgtgg tgacaatccc atcctgtgtt gtcagtccgg cagctttttg aaattctttt 223081 accgcatttt ctgttttttc gtaaaagacg cctgtaaaac cgccgggatt aaagccttta 223141 caccataaag ccccttgtaa aataaaattc atgttgcttg gttttgaatc tggagcttgg 223201 cgtttaagag gcttaaataa gcgctgtgtt gtcggcccga agttatcggc tggctctgag 223261 atacccaatt caatttgaag cgcccgagtc agaccgtaga tcgtatccca cccagttttc 223321 ccgctttctt caactgggtt atacccatgt ttgccgctgt acgtatcgtt cagccattgc 223381 tgtgtgatta agaccatttc atcaaccatt tcgattcctc ctttgttaga ttgcgttcat 223441 ttataggtgg caaacgtagg acaaaataaa aaaatggatg ccgttaagca tccattttac 223501 atccgttctc caacagcttc gctttcggtt tcagctctga aatgtagagg cctaaaagtg 223561 taagcgcgcc tcctagaaga gcgatccatg tcatgttttc gtgcagaatc aggacagaag 223621 cggcgatcgt gataaccggg accatgtaaa tatacgcact ggatttgacg gctccgagca 223681 ctccaactga ataattccaa gtggcgaagc acagggcaga agcgccaatc cctaagaaaa 223741 gcatgttgag tatatttgaa gcagatgaaa atcggcttag gtcaaaatgg aagtcgaaca 223801 aaaataaagc gggaaccata aacaataaac catacaaaaa tactctctgt gtcagctcga 223861 tgatgtggta ttcgtaggcg cttaattttt tcatgaatat cgagtatccg ccaaacacga 223921 gagcagcccc ggctgccatg atgtctccga gcggatttag acgcagtacc acattgccgt 223981 taaacgtaat caataaaagc ccgatcagtg ccgagataaa tccaatcaaa aaagtcagac 224041 gcaatttttc gccttcgagc agaaaatggg ccaaaaccgc agtgatcatc ggtataatgg 224101 acacgatcat gccgacattg gaggcgtatg tataggtgag agctatattt tctaatagaa 224161 agtataaggt tacgccaaat aaaccagctc cggcaaacaa cagctcctgc cgccaatttc 224221 tgaacggaat catgttggga cggacgagga taagagcgat aaagcccatc aaaaaccgat 224281 aaaataatat ttccattgga gagaagtcag ccagcagaac ttttgtcgaa ataaaggtcg 224341 tcccccaaat cagaatggtc acaatggctg cgatatgccc cgaagtttct ctttgtatgt 224401 tcatctgtga agctcctttt caaaaatctt catgtattgc ttcggcgtca gccccacctg 224461 ccgtttaaaa aacttcgtca tatgactctg atcgctgaat cctgtctgaa atgccgcatc 224521 aatcggcctt accccttgtt caaggagttt tttggcttga ttaatccgga ttgtttccat 224581 gtagctatta ggggtaatgc ctttttgttt tgtaaatgaa cgcaataaat gatacttgct 224641 ccagcctgtt aattcactca aatcattgag tgtaacattt tcggcataat gctcttctaa 224701 aaattcacaa accattttga cttcgtctga tggttctgga acgctgctaa ggaacgtgac 224761 atctgaataa tggcggatca gctcctctaa tagatgaaga aacagctcct ccttacgcaa 224821 agcttgtttt tcctcggata tcaaaatatg caattcctgc aggctggctg tcagctcatg 224881 gcggaataac acatgctggg agaaataagg gagatgcccg gagccagtaa tctctttcac 224941 cgccttctcc atgatatccg gcatgacatt gatacaccga taatcaagcg tccggccgtc 225001 aatctgttca cagctatgcg tgtcacgggg gttaaagagg agaagatcac ctggattgat 225061 gatatattct tgatcctgac aggccagata ccgttgccct ttttcaataa atccaatcac 225121 ataataatcg tgaaagtggt tcgggaactt ctgcataatt cccttgaagc ggtaggcttc 225181 tatatgaagg tgtgggtcaa gctgcagtgt gcgggtttcg ttttgcatgg gatgcctcct 225241 gtcggtgtgg tggtcttgga ttaagtgtag catgattttg ggggatttct tgtatgatgt 225301 tgctgtttag gaatagagaa agcagaccgt tatttgtctg ctttcgttta agaatttaaa 225361 agattttaac cctcaataat aattttatct tttttaataa aaatttattt ttcaaatatt 225421 tcagttataa tggtttggaa cagataggag gggcaaagat gtatcaatca aagaaggttt 225481 tattgttagg ttcaggtgaa ttaggtaaag aggtagtgat tgaagcccag cgtcttgggg 225541 tacagacggt ggcagttgac agttacgagc atgctccggc gatgcaggtc gcgcataaca 225601 gttatgtcgt tgatatgctg gacccagagc agatcagaac catcattgag aaagaaaatc 225661 cggatttgat tgtgcctgag gttgaggcga ttgcgacgga tgaattgctg aagcttgaag 225721 aggaaggatt tcacgttatc ccgaatgccc gtgcggccaa gctgacgatg gatcgggaag 225781 gcatcagacg acttgcggcg gaaacgcttg gacttgcgac agctggctat gaatttgcga 225841 atacatatga tgaatttata caagcggcag ctcagatcgg ttttccttgt gtcgttaaac 225901 cattgatgag ttcttctgga aaaggccaaa gtgtgtgccg ctctgaagcg gatttagaga 225961 gctgctggga gacggcgatg gaaggcggac gggtgaaaaa cggccgcgtg atcgttgagg 226021 agtttatccc tttcgaatca gaaatcacac tcttaaccgt acgtgcggtt aacggtacgg 226081 cattttgtga gccgatcggt catgtgcaaa aggacgggga ttatatcgaa tcgtggcagc 226141 cgcatgatat gacagagcag caaatagaag aagcgaagca tattgcgaaa acgatcacgg 226201 atgagcttgg cggatacggc ctgtttggtg ttgagctgtt ccttgcgaaa gatagggtat 226261 atttcagtga ggtatctcct cgtccgcatg atacgggtct tgtcacgctg gtgacgcaaa 226321 atttgtcaga atttgcgctg catgtccggg cgattctcgg ctttccgatt acagaaatca 226381 cacagctttc tcctggcgcc agcaggcccc tcaaagcgcc ggaagaatta gcggattaca 226441 ctgttgaagg attggaaaac gcactggcag tcccaaagac tcaagtgcgc gtctttggaa 226501 agccgataac aaaagccgga cgtcgtatgg cagttgcgct ttctgctgct gattcagttg 226561 aaacggcaag agagaatgca aagaaagcgt tggaccagct aattttaaaa tagagtttga 226621 acaggtcttg tcatgggaca aggcctgttt ttttctttct ccgtaaaagt tttatcataa 226681 gaatcagaaa cctgattata atgtaaaagt cttccatcga tacgggtggt tgacactaaa 226741 ggagggagat gacaaaatga aattagttcc aagattcaga aaacaatggt tcgcttactt 226801 aacggttttg tgtttggctt tggcagcagc ggtttctttt ggcgtaccgg caaaagcggc 226861 agagaacccg caaacttctg tatcgaatac cggtaaagaa gctgatgcta cgaaaaacca 226921 aacgtcaaaa gcagatcagg tttccgcccc ttatgaggga accggaaaaa caagtaaatc 226981 gttatacggc ggccaaacgg aactggaaaa aaacattcaa accttacagc cttcgagcat 227041 tatcggaact gatgaacgca ccagaatctc cagcacgaca tcttttccat atagagcaac 227101 cgttcaactg tcaatcaagt atcccaacac ttcaagcact tatggatgta ccggattttt 227161 agtcaatcca aatacagtcg tcacggctgg acattgtgtg tacagccagg atcatggatg 227221 ggcttcgacg ataaccgccg cgccgggccg caatggttcg tcatatccgt acggtactta 227281 ttcaggcacg atgttttact ccgtcaaagg atggacggaa agcaaagaca ccaactatga 227341 ttacggagct attaaattaa acggttctcc tggaaacacg gttggctggt acggctaccg 227401 gactacaaac agcagcagtc ccgtgggcct ttcctcgtca gtgacaggat tcccatgtga 227461 caaaaccttt ggcacgatgt ggtctgatac aaagccgatt cgctccgctg aaacgtataa 227521 gctgacctat acaaccgata cgtacggctg ccaaagcggc tcgcctgttt atcgaaacta 227581 cagtgataca gggcagacag ctattgccat tcacacgaac ggaggatcgt catataactt 227641 gggaacaagg gtgacgaacg atgtattcaa caatattcaa tattgggcaa atcaataaat 227701 acagcaaact agccatattc atgtctattt tgtttttatg cgggtgcagt tcgcagacgc 227761 attcttctca aaaagaaacg actattcctg tcactcttca tgtggaggat gctaaggggc 227821 tgccggtcga aggggttcaa gtgacgattg tcaaagcgcc ctcttcagat gaggagccga 227881 gtacagagat tggcgagata ctcggtaaaa cagacaaaaa cggagatatc aaatgggata 227941 ccggcagaaa aggcgattac tcagtcgcgt tgacgaaggg tgaaacatca gtaacccatc 228001 acatctcgtt aacagaggat aaaaaagatc atgccattcc attagtcttc aaagaatagc 228061 agtttccttg attttaaggg aactgccttt tttatttatt gcaggaaacc aaactatata 228121 ctggaaattt attatgtgag ataataagaa ataggtattt tttcttacga gacaaaaggg 228181 gcgttatcct ttatatcaat caaacccgga ggaaaaagaa gaagatgata caagattcaa 228241 tgcagtttgc cgcggttgaa agtggtctgc gcttttacca ggcatatgat caaagccttt 228301 ctttgtggcc gattgagtcg gaagcattct atgtttctac tcgttttgga aaaacacata 228361 tcattgcaag tgggccaaag gacgcacctt cgctcatttt gcttcacgga ggccttttca 228421 gctctgcgat gtggtatccg aatatcgcag cgtggagcag tcaatttcgt acatatgcgg 228481 tcgatataat aggagacaaa aataaaagta taccatcagc agccatggaa acgagagctg 228541 attttgcaga atggatgaaa gatgtctttg attctcttgg acttgagacg gcacatctgg 228601 ccggcctttc gcttggcggg tcccatatcg tgaatttctt actccgcgcg cctgaaagag 228661 tagagcgggc ggttgttatc agtcccgctg aagcgtttat ttcatttcat ccggatgtct 228721 ataaatacgc tgcagagctt acaggggcaa gaggagctga atcatatatc aagtggatca 228781 caggcgacag ttatgatctg catcctttac tgcaaagaca aattgtggcg ggcgtggaat 228841 ggcaggatga gcaaaggagc ctgaagccga cagaaaacgg ctttccgtac gtgttcacag 228901 accaggaatt gaaatcaata caagtcccgg tacttctgat gttcggtgag cacgaggcta 228961 tgtaccatca gcaaatggcc tttgagcggg cttcggtatt ggtgccggga attcaggctg 229021 aaatcgtaaa gaacgccgga catctgttat ctctggagca gccagagtac gtcaatcaac 229081 gcgtcttgtc ctttttatgc ggggggataa aatagtaagg aacatgaaaa gattggcatt 229141 catttttcaa aaggtaacaa atgttgtata ataatagaat ttgaatgctg ctttttttgg 229201 gagcattcta tgttatcatg cttattggag aaaaattttt cctgtaacgc tattcgatca 229261 ctatcgtcaa ataatataga tggttttaca attggaggtt tggttacact gtgaattaca 229321 tcccctgtat gattacgata ggaaacttca tttgcggatt gctggcgatt cattccttgc 229381 tatatcacaa cattcattca gcagtgcttt ttatttttac aggcatgttc cttgatttct 229441 ttgacgggat ggctgctcgt aagctgaatg ccgtttctga tatggggaga gaactggatt 229501 cgtttgccga tctggttacg tttggggtgg ctccttctat gcttgcttac agtgtcgcgt 229561 tgtataccct gccatttatc gggatcttat gcgcattgac gtacagcatt tgcggaatgc 229621 ttcgcctctc taaatttaac attgaacaaa gcaagctccc gacgtttatc ggtatgccga 229681 ttccgtttgc gggcatgtgt ctcgttattc taagcttcac ctataacccg atccttctgg 229741 caatcggcac ttgcggactc tcatatttga tggtgagtaa aataaaattc cctcatttta 229801 aaaaacatgc ggcagaaaac ctggagtctg ggagatggaa ttagttcagc agctcatagc 229861 ggattacggt tatctcgcta tttttttgat gctggtatta ggaattgtag gattgccgat 229921 tccagatgaa gtgatgatga ccgttgttgg ctatttcacg cataccgatg tattgaatta 229981 tgagctttcg atattgatta gttttgtcgg ggctttgtta ggtatgctga tcagctacat 230041 gattggcaga aaagccggac gcccgtttat cgacaagtac ggcaagtggg tcggcttaaa 230101 agaaaaaaga atgatgaaag tggaaaaatg gatgaagaaa tacggtccat attctcttat 230161 tttaggttat tttattcccg gcgtcagaca tgtgacgtgc tacttttcgg ggatcggcaa 230221 aatggatctg aaaacgtatg ttgcgtttgc tgcaatcggc gcctttttat ggtgctttgt 230281 ttttattaca atcggaaggg ttatagggat tattcatgtt taatacggct gtaaagattc 230341 tgtatcgatc attgatagag ctgacgaatc atcgtctgtc atcctatctg attaaaggat 230401 tttgcgagtc gaaaatcagc aaaccggtca ttccgctttt ctcaaaacat tttcggctga 230461 attgggatga tgtggacggt acggctgctg attacggatc gctgtccgaa ttgttcattc 230521 gacaaataaa tctggagcgg cgccctgtgt caaaagaggc gcatgcggtg gtcagccctg 230581 ttgacggtgt ggttcagacg gtaggaatca tcaacccgaa tcaaaccttt acggtgaagg 230641 gaaaagatta ctcattcgct gagctgaccg gctgtaaaag cgcagaccat caatacaacg 230701 gcggatattt cgtcgtgctg tatttaagcc cgaggcatta tcaccgtttc cattctccga 230761 tcagctgcag gtatcaaaag ctggccgagc tcggaaatcg ctcatacccg gtaaatcaac 230821 taggcttaaa atacgggaaa gatgtgctgt cgaaaaatta tcggtttgtg tacgagctga 230881 atagcggcag ccgaaatgtc ctgatgattc ctgtcggcgc gatgaatatt aattctatcg 230941 tgcagacgaa tacccgtact gaattggaga tcggcgagga gctgggatac ttttcatttg 231001 gctcaaccgt cattttggtt tttgaaaaag acgcgttcca gccgtccgcc catttagcag 231061 aaggccaaga agtccaagtc ggagaactga taggttacga agaataaaaa gaggagcttg 231121 cataaacgca gcgcctcttt ttttgaagaa aggtgagatt catggagaaa caaatcatca 231181 gctggattac agattatcag aacaccggag atgaagccgt cctgcggcaa gtgcgagaag 231241 tgtgctggcc gatcgttgaa gcggttttgc aagagaaagt aatggatgat gaacaagcga 231301 acaatttgcg cgaaaaagga atcgagcggt ttccattcat catcagcaaa taccaagcgg 231361 atgtgcagct tccggttgag acatttttac aaaatacgta tcggttttac tttcatcagg 231421 tgatgagaga atccagctaa agcttctttc aacagagaag cttttttttg ttggcaggaa 231481 aaggaaactt tttctatatc tatctcgtaa tgactagaga acctagcaga aaaggagaga 231541 tagaattgaa acgaatgata gtgagaatga ccctgccgct gctgatcgtt tgtctggcgt 231601 tttcttcttt ttcagcctca gcccgtgctg cttctgaaga aaaatattgg gatcactgga 231661 ttgaacgaca tgcacagcct ctggatgctt ccaatgcttc aaacaaagac cttcgatttc 231721 taaaaaaggt gctgaaggga aaacgaatcg ttcagttagg agaaaccaca cacggtgctg 231781 gcgaaatcaa tgccacaaag gtcagaatga tcaaatacct ccacgaagag ctgggatacg 231841 atgtattggc ctttgaatcc ggctttcctg atacaaatgc atcctacctt aatatggacc 231901 aattaacccc taaaagcacg atgaaaaact ccatttacgc tgtatggcac acagaagatg 231961 tcgtcgaatt gtttgattac atgaaagagc aaaaagagaa aggcgatccg ctgatcctta 232021 ccggttttga tattcaaagc atgaagaatt cattcaatgt agctgcgact caatgggtaa 232081 aagcggtgga ccctgagaaa gcagagttgc tctcccaatc agaaaatgat ttttcaacat 232141 tagtgacaga cagcaatacg tttgatgaat tttcgcaaaa gaaggaaaag cttgtgaaaa 232201 actatcagaa gctgatcaag ttcactaaaa cacatgcttc agagctaaaa gaaaaccttc 232261 caaaagagcc gaaagcttat gagatgttta tgcattctct tcagctgaga attgacgtaa 232321 tggaaacata tatgctggaa gaaatgaaag aaaaactaga ggagtatccg gagaatattg 232381 aggatttttc attctttatg agagaccgca tgatggctga acaatttcag tgggtagccg 232441 acacccttta tccgaaaaag aaaatcattg tctggggcca caattaccat ctacgcaaac 232501 agaatacgaa gatgataaag gactgggtac agctaaacgg ccctaacatg ggtgattatt 232561 tgccggagcg gctgaaaaaa caaacatata cgattggcat ttatgcttac tcaggtgcga 232621 gtcttgatag ctccgataat aagactgtta agccggttac aagcccgccg ccgtctggga 232681 gccttgaagc tttgctgaaa gcggcggacc gaccggctgt ttttgttgat tttctccata 232741 caaaaaacaa gaaaggcact tcgtggatgt ataccccgcg gactgcgctc tattgggggt 232801 acatggaaga gcagatgatc ctgaaggaac aatatgacgg tgtcatttgg ctggagcata 232861 tcacgccctc tgtcattatc aagtgagcgg tgtcccctgt ggtaaacagg ggatttttac 232921 atatcgcaaa aataatcaaa acatataatc cgtgatccat tattctaaaa cagaaaggag 232981 attggagcgt gcaatgtatt atgaaaaagc tgtccagaaa acaatcaatt ggattgaatc 233041 acatttacat gagcaaatat caaacgagga tattgttaac gtttcaagct tttcaaaatt 233101 ccattttcat cggatttttc aaaaagaagt cggcatgtcg gttgcttctt atattcggtt 233161 aagacgtctt gcgaatgcgg cggcagcttt gctttataca gatcatcgta ttatcgatat 233221 tgctttgtat tatcagtttg aatctcaaga agcatttacg aggacgttca aaaagatgta 233281 tcacatgccg ccaggagcat accgaacatt tatgaaacgc tttacttcaa aaaaggagga 233341 atcttacatg gagaaaaaaa tgaaaggctg ggtattgagc gggagccatc cgttccaatt 233401 cgaaatgggg attgaccggg aaaatgtaca tcagggaaaa gcttcagggt atttaaagtc 233461 aacgatggtt caggatatcg gtgaatttgc gacgatgatg cagcaattca aagcagatcg 233521 ctatctagga aaaaggcttc gtctatcaag ttttatcaaa acaaaggggg tgcagcattt 233581 tgcctcactt tggatgcggg ttgacagtgc tgctgatgat gttctccaat ttgataatat 233641 gagcaacaga cctattaccg gaacaaccaa ttggaatcat tatgctatcg ttttagatgt 233701 cccagaaaat agcgctgtga tatcttttgg cgttcaatta tctgggccgg gtcaggtgtg 233761 gatggatcat gttgtttttg aagaggtaga tgagagcgtt ccttcaacaa accttgaaat 233821 gccgggagaa cttttagatg aaccggtaaa tttatctttt gaagaggaac tacaaaaata 233881 gttttcagac aactactttt attagtgagt taatggaaaa tactatttgt tattaataaa 233941 cccttgtgct gcttaggttt gtaagagctt ggatattttt atcagtctgg gcggatctgt 234001 tcatctttgc ggcattttcc tgtatgatat agtaagagtg tgcatagcaa ctaactataa 234061 ttgaacaggg tgtttaaaac atggaaaaac aatacagagt attactttac tataaatatg 234121 ttccgattga agatccagag gcgtttagag agcagcatct ggctttttgt aaggagcttg 234181 gtttgttagg ccgtatcctt gtttcttctg aaggaattaa cggtacggta tcaggtacgg 234241 ttgaacagac tgaaaaatat atggaaacaa tgaaagctga tcctcgcttt gcggacatgg 234301 tatttaaaat tgatgaagca gaaggccatg ccttcaaaaa aatcttcgtc cgccataaaa 234361 aagagcttgt aacgcttcgt cttgaagatg atgtcgatcc gaacgaaaca acaggccagc 234421 atttgaagcc tgcagaattt tatgagaaga tgcaggatcc aaacacaatt gtcatcgacg 234481 cgcgtaacga ttacgagtat gaccttggcc atttcagagg tgcggtccgt cctgacatcg 234541 aagccttccg tgaattacct gaatggattg aagagcacaa agatatgctt gaaggcaaaa 234601 agattttaac gtactgtaca ggcggcgtgc gctgtgaaaa gttctcagga tggctggtga 234661 agcaaggctt tgaagatgta gctcagcttg atggcggaat cgtgacatac ggaaaagatc 234721 cagaggtgca aggcaagctt tgggacggcc agtgctacgt atttgatgaa agaatcagcg 234781 tgcctgtcaa ccgtgtcgag catgtgattg tcggcaagga ctactttaca ggagaaccgt 234841 gtgagcgtta tgtgaactgc gcaaatccat cttgcaataa aaaaatgata tgcacaccgg 234901 aaaatgagta taaatatatg cgcagctgca gccacgaatg ccgcacgaac ccaagaaacc 234961 tgtatgtgaa agagcataat atgacagaag aagaagtaaa cgcaagactg gcagcgattg 235021 aaacagaaga tcacgctgct gctgaataaa aaaagaacac ctcgtattga ggtgttcttt 235081 ttttctatat gctttcagtt tggctgtttg cggaaaccca ttctttttgg cggaaggcct 235141 tttcccattt tgataccacg atacaggcga tcgcatgtcc cggtacgttc acgcctgttc 235201 tcgccatgtc catgacgcgg tcaacacccg cgataatggc aacgccttca gccggcagtc 235261 ctacagcatt ggcagtcgcc agaagaacta caagcgatcc tgagggtaca gctgcaatgc 235321 ctttactggt catcacaagc acaagcatca tgagcagctg ctgggacaat gtcatgtcta 235381 cttgaaaggc ctgtgcgaga aagatacaag aaaccgataa atataagctg gagccgtcac 235441 agttcaatga caagccggag ggaacgacaa atgataccac tcgtttggga cagccgtatt 235501 tctccattct atccatcagc tgagggagaa tggtttcagt gcttgtggtg gaaaatgcaa 235561 ttaaaaacag atcccatatc attttcaata cttcgaaata cttaatctga aagatgagac 235621 cgacaagcgg aaagaggaca aagaggatca ggaacaggcc aaggaatacg gtgccaacca 235681 gcttaaacat agggaggagg agttcaatgc catattggcc tacagaagca gccatcaggg 235741 ctaacacgcc gataggagca gtgaccatga cgatttgcgt gagcttgaac ataatctgag 235801 ctgtagattc aaaaaacttc attactggtt cagaagcttt gccgatacca gctgcggcga 235861 caccaaataa aatggcgaag aaaataacgg caagcaaatc atttctggcc atgacatcaa 235921 taatgtttgt agggataata tccaggatca tttgcttgaa atcaacaact ttgtctgtgt 235981 agccggaaag ttcatgaata tctttttttg ccaaatggga gaggtcaagc ccgacacctg 236041 gttttaagac attcgctaat aaaagtccaa gccctaatac caacgttgta atcacttcga 236101 accaaatgat cgtcttgatg ccgagactgc ccattttttt catgcttccg cttcctgcgg 236161 ctccaatgac aatggtagaa aatacaatcg gcacaacaat cattttaatc aggcggataa 236221 atccatctcc gacaggcctc agtgccatcc cgaaatcagg aaaaaagtgg ccgatcaccg 236281 cgccgacagc caaagcgatt aaaatttgaa acgcgattaa ttttttcaaa tgaatccccc 236341 tttagaacga tagaatgtag gcatattcat atcattcgtg attcaaatgc aaacaccttt 236401 tttcaagtta ttttattttg acagcgcttt cattatgttg gcgaaaaagt cccccgcagc 236461 aggggggact tttttacttc atttgaatgt gctttagatc ttcttcagag gtatttgtga 236521 aaataaccgg tgttatggct gaagcggcat gctgcttgat gtaattgaga tcaaaggtga 236581 gaagcagttc gccttgtttg acggcttgtc cgcttgtgac atgtgcttca aagccttccc 236641 cattcagttt gacggtatcg atgccgacat gaatcaggat ttcagtgccg ccggcgctca 236701 taaagccgat ggcgtgtttt gtcggaaaaa tcgagacgat ctcgccgtcc gcaggtgcaa 236761 cgacttttcc ttctgatggt ataatcgcaa atccctcgcc catcattttt tctgaaaaga 236821 cctgatcagg cacatcccct aaagagactg tttctccttt aatcggataa ataaaggtct 236881 catcggaatc gggcttcagc ggtttgtcag ttaccgtgtc cagcgcggcg gcggtggcag 236941 ggacgcctcc ggccatgatt gttttgatgt cgtcttttaa ggcatcggac ttggttccga 237001 atattgcctg gaagttgttg ttgacctcca gcacacctac tgcaccaagc cgttttaatt 237061 catccttgca gacttggctt ggctgatgaa cggtcacacg aagccttgtg atacatgcat 237121 ccaggttagc gatattttgc tgtccgccca aggcctgcag cacgtgaaag gcaagctggt 237181 cttttgcaac tggagctttc tcctcattct gaccgtcttc atctgtctca cggccgggcg 237241 ttttcaaatt ccatttcaga atcgcaaatc ggaacaaata ataataaatg aaagcaaaca 237301 cgatcccgac aggaatgaca acccagccgt ttgtagacag tccgtagttc aagacgtagt 237361 caattcctcc gcctgagaac gtatagccgt ggcggacatg gaataaatca caaacgacaa 237421 agatgacgcc ggcaagaata gagttaatca aatagagcac gggcgcaacg aacaagaaag 237481 aaaactcaac cggttctgta attccggtca gcatagatgt gagcgccgca gaaatcatca 237541 cgccggagat catttttttc ttttccggac gcgcggtatg gataatggca agagcaacgg 237601 ccggcagaca gaaaatcatg taagggaaat cccccatcat aaagcgcccg gctgtcgggt 237661 ctcccgcgaa aaaccttgtc aggtcgccgg ttacggtgtt gcctgttgat gggtctgtgt 237721 attctcccat cataaaatag aaaggcgtat aaaaaatatg atgcaggcca aaaggaatca 237781 gcaaacgata gatcgttgca taaaagaaca ggccgactgt tgaatcggca attaaactgc 237841 tggctgcgtt aattccgttt tggatcagcg gccaaacgaa tgagaaaatg acgccgatca 237901 ccaatgaact gacggaagta atgatcggga caaagcgttt tccagagaaa aatccaagga 237961 ccggatgcag ctcgattgat gaaaatcgct tatataaata ggcggcgaga agcccgataa 238021 tgattcctcc gaaaaccccc atatcaatca ggtgctcggc tccttcatac ggaggctgaa 238081 ggccgagtaa ttttcccata ttgtcgaggg tgacggttaa aattaagtat ccgatgacag 238141 cggcaagtcc ggctacacct tctccgccgg ctaatccgat cgcgaccccc acggcgaaaa 238201 tcagcggaag gttatcgaat acaacgccgc ccgcatcctt tataataggg atgttcagta 238261 aatccttgtc tccgaaacgg agcaaaagac ctgctgccgg caggacggca accggagtca 238321 tcaacgcgcg gccaagctgc tgcagaattt gaaatgcctt tttaaacatg acagtctcct 238381 tttattgtgt tatgagaatg atgcactctt taatttttga gctgctttat aatcggcgat 238441 aacggttaca tgattgtgtt tttgaagaat ggaggctggt acatctgtcg tgacaggacc 238501 ttcagccatc ttttgaatgg cgtctgcttt ttcctcgccg cttgctaaaa gcacaatatg 238561 tttgctgaat tccatgatgg ttttaatgcc cattgaaatc gcgagtctcg gaaccagcac 238621 cggatcgccg ccgaagaatc tggcatttgc ctgtatcgtg ctttccgaga gcttcacaac 238681 acgtgtccgg tcttcaaaat cagatcccgg ttcattaaaa ccgatatggc cattggcgcc 238741 gatgccgaga atttggacat caatgcctcc cgcctggcgg atgagatcct cgtatacttt 238801 gcatgccgcc tcaagctgcg gattgtctcc ttgcgggata tgaatatgat caggctgcat 238861 attgatatgc tgaaaaagat gctcatgcat aaaatggtta taactttgcg gatgagatgg 238921 agagagacca gcatattcat ccaaattaaa tgtagtaacc tttgaaaaat caatttcgcc 238981 tgcctgatag tctgaaatca actgcttata caagccgacc ggtgtgcttc ctgttgccag 239041 gccgagaacg gcatctttct tagcttgtat ttgttcttta ataatggcag cgcttaactt 239101 acagagttct tcgtagtgct cggcgatcag aatcttcatg tgacaccccc tcaaagagat 239161 agacaagcac catatttgtt atgaccaatt tatgatactt gtcattacga atttagcacc 239221 gcccttatca aactgtcaat attaatttct gaaaatttgt tataaaagaa ggatacaaat 239281 ctttcatatt gggagggcaa atggtattat ggtctcaatg aaaaagaacg gattgcatac 239341 agaatgggga gaatgaaatg acagctttat attctgttat caagtttaaa atcattgagt 239401 taattaaatc gggcaaatat caggcgaatg atcagctgcc gacggagagt gagttttgcg 239461 aacaatatga tgtcagcaga acaactgtga gactggctct gcagcagcta gagcttgagg 239521 gatatattaa aagaattcaa ggaaaaggga catttgtatc ggcggccaaa atacaaacgc 239581 cgattccgca taagattacg agctttgcag aacaaatgag aggacttcgt tctgaatcaa 239641 aagtgcttga gcttgtggtg attcctgccg atcattccat cgccgagctt ttgaaaatga 239701 aagagaatga acctgtcaac aagcttgtca gagtcagata cgccgagggg gaacctttgc 239761 agtatcatac ctcatatatt ccctggaagg cggcaccggg gctggcgcag gaggaatgca 239821 ccggctcgct gtttgaattg ttaaggacaa aatacaatat tgaaatcagc aggggcacgg 239881 aatcgatcga accgatttta acggatgaaa cgatcagcgg acacttatta accaatgtcg 239941 gagcgcctgc gtttttatca gaatccctta cctatgataa aaatgaagaa gtggtggaat 240001 atgcgcaaat tattacacgg ggagaccgaa cgaaattcac cgtagaacag tcatatcatt 240061 cataaagcaa tgtgttttaa gaagggaatg gtggttctat gtttttattt acgaatggaa 240121 aagtgctgtg gggagcagtg attgctgcat tcatcctttc aattgtattt tacccttttc 240181 tgccgacgca gatgccgatt cattatgatg ttgcgaacag tccggatctg acggttaaca 240241 agctggcggg gactgtgatg ctgcctgttt tgatggtggt gtttgcatgg gcgcggaaga 240301 tcaattggca atttgtattc gcagtgtata ttttgctgat ttgccacatt gtcgtccttt 240361 gtttagcgct ctaaatcaaa cagccagaat aaaactggct gttttcttta atttcagctt 240421 catctgacaa tgaatgtggt gtataatagc tgatgatcct aaagaatatt ctgaaattta 240481 taggtgtgaa gcggcgtatt attaaaggaa aggctgtata ctttttgcag ctttaaaaag 240541 actgaatatt taaacaatta tgtgaaaggt gtgctgatta gattgaataa gcttattgaa 240601 cgagaaaaaa ctgtatatta taaggaaaag cccgacccgt cttccttggg gtttggacaa 240661 tattttacag attatatgtt tgtgatggac tacgaagagg ggattggatg gcatcatccg 240721 agaattgcgc cgtacgcacc gcttacgctt gatccgtctt catctgtttt tcattacggc 240781 caggctgttt ttgaaggatt aaaagcatac agaacagacg acggcagggt gctgctgttc 240841 cgtccggatc aaaatatcaa acggctgaac agatcgtgtg agcgcatgag catgccccct 240901 ttagacgaag agctggtgct tgaggcattg acgcaattag ttgagctgga gaaagattgg 240961 gttccaaagg aaaaaggaac gtcactgtat attcgtcctt ttgtcattgc cacagaaccg 241021 agtctcggtg tgaaggcatc caggagctat acatttatga tcgtgctttc gcctgtcggc 241081 tcctattatg gcgacgatca gctgaagccg gttagaatct atgtcgaaga tgagtatgtg 241141 agggcggtca acggaggagt cgggtttgca aaaacggctg gaaactatgc cgccagtctt 241201 caggcacagc ggaaagcgaa tgaactgggc tatgaccagg tactgtggct ggacgccatc 241261 gaaaagaaat atgtggaaga agtagggagc atgaacatct ttttcgtcat aaacggggaa 241321 gctgtcacac ctgctttaag cggaagcatt ttaagcgggg ttacacgtgc gtctgcgatt 241381 gaattgattc gaagctgggg cattccggtt cgtgaagaga gaatatcgat tgatgaggtg 241441 tatgcggcct ctgcacgcgg agaattgaca gaggtctttg gcacaggcac ggcagcagtc 241501 gttacgcctg tcggtgaact caacatccat ggaaaaacgg tgattgtagg cgacgggcaa 241561 atcggggacc tctcgaaaaa gctgtatgaa acgataacag atattcagct tggcaaggta 241621 aaaggcccgt ttaactggac agtggaagtg tgaaaatcga aaaagaacct gcccggaggc 241681 aggttctttt tattttgaat gagtcatatc agcagccggc tggcttttgc ggttttttac 241741 ataatatatt gcatagcaaa tggccataaa tggaacgccg caatagagtg cgattctttg 241801 attcggatca aaggcaatgc caacgacgga agccaggcat aacaggaacg cagcaatcgg 241861 cacgaacgga tacaaagggg ttctgtattt caaatcagta accttgtttc ccgcttcgat 241921 ataacgtttt ctgaacatga attgagaagc agcgattccc atccacacga caacgacggc 241981 aaaaccggaa atcgacacga gcacaacgta tacagtgtct ggcgcaaata cgctggacag 242041 caacgacaga atgccgccga tcatgctgaa caccagcgcg ttaaaagggg ttccttttga 242101 cgtcagcttt gcaaatgtcg gatgaagcgt tttttctttt gataaagacc acagcatccg 242161 ggaagaagcg tagagtccgg aattagccgc tgacaggatc gctgtcagga taacaaagtt 242221 catgatatcg gctgcgtatg gtacaccgac tctgtcaaag acagcgacaa acgggctttt 242281 gatgacacct gcatcttgaa tcggaatcag ccctgacagc acaaaaattg ttccgacaaa 242341 gaagagcgag agacgccaga ccgttgtttt tatcgctttt ggtatcgtct tgtcaggatc 242401 aacgctttca ccggctgcga ttccgattag ttccgttccc gaaaaggcaa aattgacgga 242461 cagcatcgtc atcaaaatcg ggacaaatcc attgggaaaa agcccgcctt ccgccgtgaa 242521 gttggacagc atcggagcgg cttctccgcc tttgatcggg atgatgccga acatggcaga 242581 gccgcctaaa agaataaata atacaatggc taatactttg atgctggaaa accaaaattc 242641 tgattcagcg aaaaacttga ccgaaaatgc gttaagcaag aagatgaaca gcgcaaagac 242701 ggcactccac atccaaaccg atgtatgggg gaaccagcgc tgcattaaca ggccggctgc 242761 tgtgaattct gatcccaatg ccacggtcca tgtcagccaa tacagccaag cgaccgtaaa 242821 tccggtgccc ggccctatgt atttggctgc ataggtgtga aaggcgccgg tcacaggcat 242881 ggcgactgac agctcaccga ggcatagcat gaccagatag acgatgccgg ccccgactaa 242941 gtaggcgagt atcgttccgg ccgggcctgc ttgctgaatg gtataacctg agcttaaaaa 243001 cagcccggtt ccgatgacac ctcccaagga aagcataaag aggtgccggc ttttcatact 243061 tctctgaaag gttgtctcat tcttgttgtg ggcagagttc atctttttcc aactttctat 243121 cagcgattta tttccttcct aataaaaaat ctcatgtcag aaagtgacac gagactccgg 243181 cgaaccggct ttaagttaga atatacaaac tattccgata agtcaagttg tttttaaaga 243241 gcgggcccaa gccgcaattt cttgaatatt ttcgggtttt gtccggcagc agccgccaat 243301 cagcctcgct cctttttcat gccaggtgcg ggcgctcgcc ccgtaagatt ctgcgcatgc 243361 tgcgccgttc cacgtttttg tttccggatc atattgctca cctgaattcg ggtagacaat 243421 gatcggtttt gacgtgttct tttttaactc ctctatcaag gaagggatat gctgaagcgg 243481 cgtgcagttg atgccgagtg ctgcaatttg gcggtgttca tcaagccacg atgcgcagtc 243541 agctgcaggt gttccgtcac tgatatgcaa gccgtcttta gcactgaagc tgatccatgc 243601 atacgtttca ggaaattcct tcaacagccg aacaatcgct ttggcttcag tcagacacgg 243661 aatcgtttcg catgccaata catcagctcc ggcttcaatc agcgccttca tccgggggcg 243721 atgaaattca atcagttcat cttctgatat tgcgtagttg ccgcgatact cagacccgtc 243781 tgcaagataa gcgccataag ggcctataga agccgcaatg atcggttttg gccgattcaa 243841 acggttctct tcaagcgacc aaaattcatc acgtgcttca gctgcgatgc tgacggacaa 243901 ctcgatgagc cggcgtgctt ccgcttcgct cagcccgcgt gcggcaaagc cttcaaatgt 243961 agactgatag ctggcggtga ttgcacaatc ggcgcctgcc gcaaaataat cagtatgaac 244021 ttgtttaatc agctccggct cttccatcag gatttttgcc gaccacagac tgtcattcaa 244081 attacagccc ttgcgttcaa gctcggtcgc catggcgccg tctagcacaa taagcgggta 244141 tgtatctaat atgtgttgga taggattcat agaatgtacc gatgccttct ttcagatttt 244201 tttgaaaaag atatgaaaat cgtaatggag gcttacgtgt ttgtcaataa acgcaaaaag 244261 agaaaggtgt tcagcccata tgtctgaaca cccttttctt atgatatttg tttgttgtgc 244321 gtgtcagtct ttgtgtctga aaccggccag cactcaatgc cattatggtt tttgagcaca 244381 tctttataaa agaccggatc cttgcctgct tttttctggc gtgtatagtc tttcagcgcc 244441 gtaaaaacga cctttgatag taagaaaatc gcgattaaat tcacgatgac catcaaaccc 244501 atgaacaaat cagcaagatc ccagacgagc tggactttgg caacacagcc aaacacgatc 244561 attgccagca cgccgatacg gtagacaaaa atcagttttt tgcttttgtt caaaaagccg 244621 atattggttt cgccataata atagtttcca attagagcac agaatccgaa taacaaaatc 244681 agaatcgcga gaaagcctga tgcccatgat ccgacatggg agctgaggga ggcttgtgtc 244741 aaggcgattc cgctcagacc cggagtatga taggcatccg aaaacagaat gataaaagcg 244801 gtgcttgtac aaatgaccag tgtatctgtc agtacaccaa aagcttggat cagcccctgt 244861 ttgacgggat ggcttgttgt ggcggtggca gcggcatttg gtgcgcttcc cattcccgct 244921 tcgtttgaaa agattccccg tctgacgcct tgcatgagtg ccgcgcccaa agccccgccg 244981 gcggcctggt caaaaccaaa cgcatttttc acgattagcg caagcacacc tggcagctgc 245041 gtaatgttgg agaaaatgac gaaaaacgca actccgatat acaggacagc caatacgacg 245101 acaatggatt cagccagctt tgcaatgcgc ttgactccgc caaaaataat cgtgccgaat 245161 acagcaatta aaatgagtcc caatgtcagg cggtttgtgc caaacgcgtt ttcaaaggca 245221 aggctgactg tattggattg aaccgagttg aagacgatac cgaacgataa ggtgattaac 245281 acagcgaaca gcgcgcccat ccaccttttg ttcagccctt tttccatgta atacgccggc 245341 ccgccgcgga agccgtttac atcttttact ttataaatct gagccagtgt gctttccaca 245401 aagctggatg ctgatccgat aatggcgata atccacatcc agaagattgc accgggcccg 245461 ccgagtgcaa tggcgatagc aatgcccgta atatttcccg ttccgacacg ggccgccatg 245521 ctgatgcaaa aggcttgaaa cggagaaatg ctgttttttg accgggaagc agcaccttct 245581 cttaataccc tgaccatttc tttcagcatg cgaacctgta aaaacttaag cctgaacgta 245641 aaatagattc caaaagaaag gagcaaaaca attaatagct ttgaccacaa aagatcattt 245701 gcaataccga cgatatgttc taggatttgc tgcatagaat cacctctttt ttcatgttta 245761 aaaaatgctg agctcccatt cctgcgccat atgcttcagc agcataccgc cagtgaggct 245821 gttgccgtat tcatcaatgg caggcccgta aatgccgatg ccgcatccgg attgaaaagg 245881 ctgttctctt ctggcgcttg gaggcaccag cgccatgatg ccgccggaga cgccgctttt 245941 ggccggcacg ccgacaaacg ccgcatattt gcctgaagcg ttgtacatgc cgcacgtcag 246001 cattaatgcc ttggccaatt ttgccacatc ttttggaatc acctgctcgt gtcgaatcgg 246061 atgatacccg tcatgagcaa ggatcaggcc gatcaacgca atatcttctg tagtgctctc 246121 catagcgcat tgcttcaagt acacctcaag tgtttcttct acttcagctt ctaaaaagtt 246181 tgtttctttt aaatagtagg ccagcgctct gttgcggtgg gcggtttccc attcagaacg 246241 gaatacttct tcatgaattc ttggccgttt tcctatcaaa gtttccatca ccgagtaaag 246301 aaactcgagc ttttcgtatg cagattctcc gggaaggatc gaagcgatgg tgagggcacc 246361 cgcgttgatc atgggattga agggctttcc cggcttgttg atttcgagcc gaatgattga 246421 attaaaggcg tcacctgtcg gctcgacatc tacgcggtca agcacatagg gaatgccgcg 246481 gctcatgcag gcggcaataa agctaatcac ttttgaaatg ctttgcatgg taaaagagac 246541 gttccagtcg ccggcgtgta tcatcgttcc atcaggctcc aatacacaga tgccgagctg 246601 tgaatcattg acttttccta aagcggggat atagtttgcg ctttgtccat tggcggcaaa 246661 agggcgatag tattcaaccc aatcatgaag ctgtaacgcc gggtttatgt ctttctggtg 246721 ctcttttatc aattctttca tcgaattcct cctcactgat ttttttctta aaggactgag 246781 gtgtatcaaa acgaaggcta agggggcgtt aaacgctttc ataatagcgg aaggtataat 246841 tactgtataa tggagactac agaatcatac aaaatacgac aaaaacattt tgaaaataag 246901 cagtaagatt tataaaaacc tcatgttctg ggtcaaaagc aatttgcagg ttttctcccg 246961 attccccaaa ataaaaagcg aggatgtgat caacataaaa ctggaacggt ttattgaaaa 247021 agacggatat atactggccc tcatgctgat tacggtgccg ctggccggtg aactgaaatt 247081 ttatcccctc aatgaagaat tccgggtcag ctttggggca ccggtttttt tcttcttttt 247141 atcattgttg cggcatgtgc ccgctgtgct gccgggtttt ctgactggag cggctgtttt 247201 catctttcgc gtctttctgg aattatgggg cggaggacac aatgggctga ctccgattct 247261 gtatgatcaa gcgtctggct ttttctttta tatgacttac gcctgtctgt tttccatatt 247321 aaaggccaat cgtttccgtg aacggccgat tatgctcggt ttcattgggt ttatgattga 247381 agttgtgtca gattgtgtcg agctaactgt gcaatttctc atttttcata cggttgtcac 247441 gcctgagaaa atcactgaca ttgcggtgat tgcgatttct cacacattta ttgtgatgag 247501 cttttatagt gtgctgaagc tgtatgaaac acaatcgaga gaaaaacaga caaggcagca 247561 gcacgagcac atgctgatga tcgtttccaa tttatatgaa gaaacggtgc acctaaaaaa 247621 gacattgaaa acgacagaga aagtgacaaa cgattcgtat cagctctatc gggaaatgaa 247681 gggcaaggat gttcagctga gcggcagaat cctgagactg gccggagaga ttcatgaagt 247741 gaaaaaggac aaccagcgga tattcgcagg gctttcaaaa ctgatttcga atgagagttt 247801 gagagattat atgagggctt ctgatttgct gcagctcgtg attcgaatga atgaaaagta 247861 cgctgaagca ctagggaagc agattgattt ttactgctcg atcgagggag agcatgacga 247921 atatcacgta tttatcgtgc tttcgatcat taataatcta acagcaaatg cggtagaggc 247981 tatggatgaa gagggaatgg tcagcctgag gctccgtaag ccaaatgaga gtatggtaga 248041 attccaggtg gaagacaatg gccccgggat ttccgagaaa atcggagaca ttgtgtttga 248101 cccgggcttt acttcaaaat atgacgaatt tggcacgcct tctacgggta tcggactttc 248161 ctacgtaaag gaaatcgtga cagagctaga aggggatatc acgtttgata atcagcagcg 248221 gggagtggtg tttgccatca ggctgcctgt ccggcatttg attcagaaag ggtgaaccaa 248281 aagctatgcg tttttttatt gcagatgatg accgtgcggt gcggtcaatt ttaaggcaga 248341 tcattgagga cgaagatctc ggggaagctg ctggtgaagc agacgacgga agccaagtgg 248401 aagggcatat gctgcaattt aagcagattg atattttatt aatcgatctg ttaatgcccg 248461 gaagagacgg cattgagacg attcgtcaga tccagaatac gtactccggc aaaatcgtaa 248521 tgatctctca agtggaggcg aaggaaatgg tcggggaagc gtactcgctc ggcatcgaat 248581 attttatcca taagccgatt aaccgcattg aaattgtcac ggttctccaa aaggtgaagg 248641 agcggatcga gcttgaacac tcgattggag ccattcagca ttctctaagc cggcttgtca 248701 atcggactga acggaaagcg cgtccccagc agaagagtga cagcggttta aaagaggcag 248761 gaacattcct gttgtccgag ctgggcatga tgggagaagg cggcgcacat gatctcatgg 248821 cggtcctgca gtatttagca gaacacgagc aatccgagcc gcacgaaaaa caaagccctt 248881 cgctaaaaca aatattcacc caagtagcgg tacggaagct ggggacagga gcctcacaga 248941 cggaagtcaa tcgcgaaatg aaagcctcgg agcagcgtat ccgcagagcg attattcatt 249001 cgctgcacca ttttgcttca ctgggcacaa ctgatttttc gaatccaaaa tttgaaacct 249061 atgcatcgaa attctttgat tttccggttg tcagccagaa aatgaaagaa ctccaatcca 249121 aggatgcaaa accccttgca cctgctagaa taaatatgaa aaaattcatc cacgtgtttt 249181 ttttggaagc aaagcttttg catgagacga tgaaacaaag aaggatataa accaaacagc 249241 cggctgacca ggctgttttt ttgctgcgca gaatcccggc cggacagtga tttaccgctt 249301 ttttataaaa tatcagaaaa taaagatatt gacttattgt ttatttgtct tacaattaaa 249361 caaaaggata tatgggaagg agcggatgtg aaagaaaaat taataaaagc gcttacagat 249421 agaggccgta tacacaaata acaggaggtt atgttgatga gccgtatcag aaaagcaccc 249481 gctggaattt taggttttcc ggttgctcct tttaacacac aaggaaaact ggaggaagaa 249541 gctctttttc aaaacattga gtttttgctg aatgagggct tggaagcgat atttatcgct 249601 tgcgggtctg gtgaattcca atctctcagc cagaaggaat atgagcaaat ggtggaagtc 249661 gcagtctcgg cagccggagg aaaggtgccg gtctacacgg gggtgggcgg caacctcagc 249721 acagcgcttg attgggcgca gctgtcggag aaaaaaggcg ccgacggcta cttgattctg 249781 cctccgtatt tggtgcatgg cgaacaggag gggctgtacc agtatgcgaa aacgattatt 249841 gaaagcactg acttgaacgc gattctttat cagcgcgata acgcagttct ctctgttgaa 249901 cagatcaaac gtctgaccga atgtgaacag cttgtcggtg tcaaagacgg ggtaggaaat 249961 atggatttga atatcaatct cgtctatacg atcggcgacc gcttgggatg gctcaacgga 250021 atgccgatgg ctgaagtgac gatgccggct tatctgccga tcgggttcca ctcttactct 250081 tcagcgattt caaattatat cccgcatatt tcgcgaatgt tctatgatgc attgaaaaac 250141 ggaaatgacg agcttgtgaa ggaactctat cggcatgtga ttctgccgat caacgacatt 250201 cgcaaacaac gaaaaggcta cgccgtatcc ttgattaaag ccggtatgga aatcatgggt 250261 ttgaatgtaa ggaatacagc cagaccgcct gtcggcccgg ttgaaaaaga tcattatcag 250321 caattggaag caattttgaa gcaggcggct gaccgttttc cgaaaaaagc cgcgacggtt 250381 tgaccagaaa aaacacgaaa ggggcaatgg gcatgtctgt gatcacggaa caaaacacgt 250441 acctcaactt tattaacgga gagtgggtta agtctcaatc aggcgatatg gtcaaagtcg 250501 aaaaccctgc cgatgtgaat gatattgtcg gatatgtaca gaattcaacg gctgaagatg 250561 tggaacgtgc cgtcaccgcc gccaatgaag ccaaaacggc ttggagaaag ctgacgggtg 250621 ccgagcgcgg ccaatactta tacaaaacag cggatatcat ggagcagcgc ttggaggaaa 250681 tcgccgcctg tgcaacgcgt gaaatgggta aaacattgcc ggaagcgaag ggagaaacag 250741 cccgggggat tgccattctg cgctattacg ccggagaggg catgcgaaaa acgggtgacg 250801 tcattccgtc tactgacaaa gacgcgctca tgtttaccac ccgtgttccg ctcggtgtgg 250861 tcggtgtgat ttctccgtgg aacttcccag tggcgattcc gatttggaaa atggcgccgg 250921 cattggtata cggcaatacc gttgtcatca aaccggcgac agaaacagct gtgacatgcg 250981 cgaagatcat tgcctgcttt gaggaagcgg ggctcccggc aggggtcatc aatttggtga 251041 caggcccggg ttctgttgtc gggcaggggc ttgctgagca tgacggtgta aacgccgtta 251101 cgtttaccgg ttcaaatcaa gtcggaaaaa tcatcgggca agccgcttta gcgaggggag 251161 ccaaatatca gcttgagatg ggcggcaaaa accctgtcat cgtagctgat gacgctgacc 251221 ttgaagctgc ggcagaagct gtcataacgg gggccttccg ttcaaccggc cagaaatgca 251281 ccgcgacaag ccgtgtcatc gtacaaagcg gaatttacga gcgctttaaa gaaaaactgc 251341 tccagcgcac aaaagatatt acaatcggag acagcttaaa agaggatgtc tggatgggac 251401 cgatagccag caagaatcag cttgataact gcctgtcata cattgagaaa ggcaaacagg 251461 agggcgcttc ccttttaata ggaggagaaa agctggagaa cggaaagtat caaaacggct 251521 attatgttca gcctgccatc tttgacaatg tgacatctga gatgacaatt gcccaggagg 251581 aaattttcgg tccggtgatc gccttgatca aggtggactc gatagaggag gcgctgaaca 251641 tcgccaatga tgtgaagttc ggtttaagtg catccatctt cacggaaaac atcggccgaa 251701 tgctttcttt cattgatgaa atcgatgccg ggctggttcg gatcaatgca gaaagcgcag 251761 gtgttgagct gcaggcgcct tttggcggca tgaagcagtc gagctcccac tcccgagaac 251821 agggtgaggc agcgaaggac tttttcacag cgatcaaaac tgtttttgtg aagccgtaat 251881 ggtgctggaa agaggcgtgc gtctctttcc cggtttatca caaccagcat atgattctct 251941 actttgaaaa ggagaagata ctatgaaaaa agactttgcg agtgttactc cggcgggcaa 252001 aaaaacgtcc gtgcgctggt tcatcgtgtt tatgctgttt cttgtgacct ctattaacta 252061 cgcggatcga gcgacgcttt ccatcaccgg agattccgtc cagcacgatt tgggattgga 252121 ctcggtcgcc atgggatatg tcttttctgc ctttggctgg gcctatgtca tcggacagct 252181 tccgggcggc tggctgctgg accgttttgg ttcaaagact atcattgcgt taagcatctt 252241 tttctggtcg ttttttacgt tgctgcaagg ggcgattggc tttttctccg ccggcacagc 252301 gattatcctg ctgtttgcac tgcgttttct ggttggttta tcagaagcgc cttcatttcc 252361 cggaaacggc agagttgttg cctcatggtt tccaagctcc gagcgcggga cagcttcagc 252421 cttttttaat tcagcacaat acttcgcaat cgtcattttt tctcctttaa tgggctggct 252481 tacccactct ttcggctggc attccgtttt cgttgtcatg ggtattgcag gcattcttct 252541 ggctgtcatc tggctaaaaa cggtgtatga accgaaaaaa catccgaagg ttaatgaagc 252601 tgagcttgcg tacatcgaac agggcggcgg gctgatttcc atggatgaca gtaaaagcaa 252661 acaagaaaca gaatcgaaat ggccgtatat caaacagctg ttaacgaacc gcatgctgat 252721 tggcgtgtac atcgcgcaat actgtattac gactctcacc tatttctttc tcacatggtt 252781 tccggtatat ttggttcagg cccgcggcat gtctattctt gaagctgggt ttgtcgcttc 252841 cctgccggcg ctgtgcggat ttgccggcgg cgtgcttggg ggcattgtgt cagacatctt 252901 actcaaaaaa ggccgttcac tgacctttgc aagaaaagtg ccaatcattg ccggcatgct 252961 gctgtcttgc agtatgattg tctgtaacta cacagattca gcatggctcg tcgttgtcat 253021 tatgtcgctc gcgtttttcg gaaaaggctt cggcgcattg ggttgggctg tcgtgtcgga 253081 cacgtctccg aaagaatgtg caggattaag cggcggtttg ttcaacactt tcgggaatat 253141 tgcctcaatt acaacaccga ttattatcgg atacattgtc aatgccactg gatctttcaa 253201 tggcgcgctt gtgtttgtcg gcgctaacgc gattgcggcg atcctcagct atttgctgct 253261 ggtcgggccg atcaaacggg tcgtgttaaa gaaacaagaa caagaccccg atcaatcgtt 253321 gcctgtctaa tatttatgaa agcgctttat aaagggagga aaatgcatga gttcaccgat 253381 acaagagcag gttcaaaaag aaaaaagatc gaatattccc tcaatttctg aaatgaaggt 253441 gattcctgtt gcgggacatg acagcatgct gctgaatcta agcggagcac acagcccgtt 253501 ttttacccgg aatatcgtaa tcttaacaga cagcagcgga aatcagggag tcggcgaggt 253561 gcctggcgga gagcatattc gccgcacact ggagctgtca gagccgcttg ttgtcggaaa 253621 atctatcggt gcgtaccagg cgatattgca aacggtcaga aagcagtttg gcgatcagga 253681 caggggaggg cgaggaaacc agacgtttga tttgcgcacc actgtgcacg ccgtcaccgc 253741 actggaagcg gctttgttgg atttgcttgg aaagtttctt caggaaccgg tcgcggcttt 253801 gctgggcgaa gggaagcagc gtgatgaagt aaaaatgctc ggttacctct tttacatcgg 253861 cgaccgaaat cggacgacct tgccgtatca aagcgatgag cagtcagatt gtgcgtggtt 253921 ccgtctgcgc catgaggaag cgctgacgcc ggaggccatt gtgcgtcttg ccgaatccgc 253981 acaggagcgc tatggctttc aggatttcaa attgaaaggc ggggtgctgc ggggagaaga 254041 ggaaatcgaa gctgttaccg cattatcgaa acgttttcca gaggcaagga tcactcttga 254101 tccgaacggg gcatggtcat tagaggaagc tattgcatta tgcaaaggaa agcaagatgt 254161 gctcgcgtat gcggaagatc catgcgggga tgagaatggc tactccgctc gtgaagtaat 254221 ggctgaattc cgccgcgcga cagggcttcc gactgcgaca aatatgattg cgactgactg 254281 gcgggaaatg ggtcacgcga ttcagctcca cgcggtcgat ataccgctgg ctgatccgca 254341 tttttggacg atgcaagggt cggtgcgggt tgcgcaaatg tgccatgatt ggggtttgac 254401 atggggctcg cactccaaca accactttga tatttccctt gcgatgttta cccatgtggc 254461 agcagcggct ccggggcgga tcacggcgat tgatacccat tggatctggc aggacgggca 254521 gcgattaacg aaacagcctt ttgagatttc ttctggctgt gtcaaggtgc cggataagcc 254581 tggactaggc gtcgatattg atatggaaca agtggaaaaa gcgcatgaga tctatcggaa 254641 aatgaattta ggcgcacgga atgatgcgat cccaatgcag ttcctgatca gcaactggga 254701 atttgaccgg aagcgcccgt gtcttgtgcg ataagtttga ttgtaaatat tgtcatatcc 254761 gctattttgt cttacaattg aacaactgaa gggagagttg ttcgtgtacg aaggtttaga 254821 ggatttgaaa gtcgatacag tcaatcggaa aacattagcc aagcaggtca tcgaacggat 254881 tgtccattta ttatcgagcg gacagttgag ggccggagac aaattgccga cagaaatgga 254941 actgatggac attttgcatg tcagcaggcc ggtgctacgg gaagcactca gttcacttga 255001 aacgctgggc gtcattacga gaaaaacacg agggggcaca tatttcaacg ataaaatcgg 255061 catgcagcca ttttccgtca tgcttgcttt ggccactgat aatcttccgg ctatcattga 255121 agcgcggatg gcgctagaac tcgggctcgt gacaattgcc gcggaaaaaa tcaatgagga 255181 agagcttcag cgtttgcaga agacgatcga cgatattgcc aacagcactg acaatcatta 255241 tggtgaagcg gataaagagt tccatcgaat tattgcgtta agcgccaata accccgtcgt 255301 tgaagggatg attcagtccc tgctgatcac ccatgcgaaa attgacagcc aaattccgta 255361 cagggagaga gatgtaacgg tcgaatatca caaaaaaatc tacgacgccc ttgccaaaag 255421 agatccgtac aaagcacatt accacatgta tgagcatctg aaatttgtcc gtgacaaaat 255481 tctaaaagga atggatgaaa aataatggtg agcaaccgca gttgaaacgt aagagctgcg 255541 gtttttttaa accaatttag aaaacgctta ctaaaatatg aggagtgatt ttcatatggc 255601 gatgaacctc aggaagaacc aagcccccct ttacatcaaa gtgcatgaaa tagataacac 255661 cgcgattatt gtaaatgatg gagggctgcc aaagggcact gttttctcat gcgggctcgt 255721 acttgaagag gatgttcctc aaggccataa ggtggccctc accgatctca atcaagggga 255781 cgagatcgtg cgttacggag aggtgatcgg atttgctgat gagacgatca aacgcgggag 255841 ctggatacgg gaagccctcg tgagaatgcc cgctcctccg gcgttagacg atcttcctct 255901 cgcaaacagg gtgccgcagc cgcggccccc acttgaagga tatacatttg aaggataccg 255961 aaatgcggat ggcagtgcgg ggacaaaaaa tatcctcggc atcacgacaa gtgttcaatg 256021 tgttgttggc gttttggatt atgcagtcaa acgaataaaa gaagagctgc tgccgaaata 256081 cccaaatgtc gatgacgttg tgccgctgca tcatcaatac ggatgcggcg tggcgatcaa 256141 tgcgcccgac gctgtcattc cgatccgcac gattcaaaat cttgcgaagc atccgaactt 256201 cggcggtgaa gtaatggtaa tcggattggg atgtgaaaag ctcctcccgg aaagaattgc 256261 ctccgaaaat gatgatgaca ttctatcgct ccaggatcac cgaggttttg cggcgatgat 256321 ccaatccatt ttggaaatgg cggaggaacg gttaatcagg ctgaacagca gaacccgggt 256381 gtcatgccct gtttcggatc tggttatcgg cctgcaatgc ggcggcagtg atgcgttttc 256441 cggcgtgacg gcgaaccctg ccgtggggta tgcggctgat ttattggttc gcgcaggtgc 256501 aacggttttg ttttctgaag tgacagaggt gcgggatgcc attcatttat taacgccgcg 256561 ggctgtcagt gaagaggtcg gacaatcgct gatcaaagag atgaagtggt atgacagcta 256621 tcttcggcgg ggagacgcag accgtagcgc aaacccgtca ccaggcaata aaaaaggcgg 256681 attatccaat gtggtggaaa aagcgttagg ttcggtagcg aaatcaggca caagccccat 256741 ctccggcgtg ctcggccctg gtgaaagagc aaagcaaaaa ggcctgctgt tcgcggcgac 256801 accggcaagc gattttgtgt gcggcaccct gcagctggct gcgggcatga atttgcaggt 256861 gtttacgaca gggagaggaa caccatatgg cctggctgct gcgccggttc tgaaagtatc 256921 gacgcggcat tccttatcag agcattgggc tgatttaatc gatatcaatg ccggccgaat 256981 cgcgacagga gaggccagta tcgaagacgt aggctgggaa atcttcagga cgattttgga 257041 tgtggcaagc ggccgcaaac aaacgtgggc agaccgttgg ggtcttcata atgatttgtg 257101 cttgtttaat cctgctccag tgacttgatt catgttttta tagcggaaag atggaatatg 257161 ctgtaaaatg aaaatcagcg tataggaaac ggaggggtta cagcatggca ttcattagat 257221 tccgagtgac acgaattcaa tagtgaacaa ctctcgcctg aatgcgagag aatcgggatg 257281 aatccgccta tgtatgagcc cttatatggt tatcaaaaaa gagggtggcg tgcctgccct 257341 tttttgtgcc ttcaagcatc ccttctctct actgcaggcc ggagcatgag aaaggggaaa 257401 tgggatgaca aaccttaacg aaaaacagct tatcactgag attgtcgggc ttgcacgcag 257461 ccaaggtttg acggttcatt ctgagaacgc gcaattgaat gaaaccggaa tggactttca 257521 agttgtattt gccaaggacg acacaggtat gccatgggtg ctgcgaaaac cgcggcgaag 257581 tgatgttgtg gaaagagcat ctgcagaagg cataacgctt gcctttctcc gcgcgaatct 257641 gactgctgat gtgccggatt ggagaattca tacaccggaa ttgatcgctt accccatgtt 257701 aaaaggaacg ccggctgctg gaattgactt ggaacaaaag caatatgtat ggaatatgga 257761 tcatcagccg ccgtcagacg actttgtccg cacacttgcc gacatactgg ctgaattaca 257821 tggcacggat caaatatctg ctgggcaatc cggaatagaa gtgataaggc cagaagattt 257881 caggcaaatg acagcagact ctatggttga tgtgaagaat aagcttggcg tatctacgac 257941 gctttgggaa agatggcaaa agtgggtaga tgatgatgca tactggccgg gtttctcttc 258001 tttgatacac ggcgatctcc acccgccgca tatccttatc gatcaaaatg gacgtgtcac 258061 aggacttctg gattggacag aagcgaaggt tgctgaccca gccaaggatt ttgttcttta 258121 tcaaaccatt ttcggagaaa aagaaactgc ccgtttgctt gaatactatg atcaagcagg 258181 cggccgaata tgggcaaaaa tgcaggaaca catctcagag atgcaggcgg cgtatccggt 258241 ggaaatcgcc aagctagctc tgcaaacaca gcaggaggaa cacatcaata tggcgctgga 258301 agcacttggt gtaacatcgg attaagaatt gacttcgttt catgaaccga gtattataaa 258361 ctctacaaat aatagaacgg attaacaatc gtgaggaaga gcaagtacgc atcagaatgg 258421 aggttcagag agtcggtggc aggtgtgaac cgatcctccc ctgatgccga atgggcttct 258481 gaattgcttt gctgaacgga tagtaggcga tgccgggttt ctctccccgt taccaagaga 258541 ggagtatcga aacataggtt ttctgtactt agagtgaacg gctgtatagc tgttaataaa 258601 ggtggtaccg cgagaccctc gtcctttgca taggacgggg gttttttgtg tttcttaaag 258661 gaggtgacgg ccaatgtacg atggctggtg gtggcatagc agatgagtta gaaaggagga 258721 tatcaaatgg tcattgcaac tgatgatctt gaggtcgcat gtcctaaatg tgaaagagcg 258781 ggagaaatcg aaggaacacc ttgcccggcc tgcagcggaa aaggtgttat tctgactgct 258841 caaggatata cgcttctcga ttttatccaa aagcatttga ataagtaaag gagaaaagct 258901 gagctgagat gagagcagaa gagcagagta agattcgtga ggccgcagca ggtacgattt 258961 ttttgctgat cggaacagtt tgttttgcgt ctaaatcgat ttggataaaa tgggcatacc 259021 aaatgggtgc tgagccagat gccgtgctgc tatacaggca gctgctggct gttccgctgt 259081 tttggctgat ttttttaata taccgtcctc caatgccaga cggtaagaaa aaaggagacc 259141 tatggaaggc ttgtggcgcg ggagtgtttt gtttttttct gtctcccttg cttgatttta 259201 tcgggctgaa ccatgtatcc gcaatggttg aacgtatatt gctgatgagc tatccgttgt 259261 ttgtgtttgg attcaccgcg tgtcgtgacc ggaaaatgtc ctcaattcag gaccttttcg 259321 cagttctggc ggtcatgttt gggcttttct tggcgctggg cggctggaat gctgagcttt 259381 tccaggcgaa tatgattgga gctgtattca ttttgttatc ttcggccgtc tatgctggtt 259441 atcttgtcct ttccgggcat ctcgtccatc aaatcggagg gatccgtctc aatgcatacg 259501 ggatgacagc tgctggagct gccatgatgc tttacacagg gataaaatcg gcggctggca 259561 tgaatacgcc aatggcagca tatccgcttt ctatgtatgg tttgttcgca gtaattgcag 259621 tcgttaccac agtgattcca tttgtgctaa tgcttgaggg cataaaacga atcggggcac 259681 agcgagccgc cgccatttca atggcagggc ctatcctgac gattttctat ggagctttat 259741 ttctcggtga acggctcggg ctcattcaag tcattggatg cggtggcgta ttttttgtca 259801 ttacgggcat ggaatacagg aagctgaaaa caggaaaaaa agaataattt ttataaaaca 259861 cacacgtttt tcaattacaa taagtgtaat tacgtgtgtg ttttttgatt ttgtaaaggt 259921 taggtgagga gatgcagcgc atattgcttg tagaagacga ccactcaatc agtgaaatgg 259981 tggatcatta tttaacaaaa gaaggctttg gaattgtgca tgctttcgac ggagaagagg 260041 gcatccggct gtttcagcag ggttcatacg atttggtcct ccttgatatc atgctcccga 260101 agctgaacgg catggatttt ctgaaaatca tccgggaaaa aagcaatata ccggtcttaa 260161 tgatttcggc aaaagatgga gatgtggaca aggcattggg actgggcttt ggggcggatg 260221 attatatcgc caaaccgttt tcgatgattg agctgacagc ccgagtaaaa gccgcgatac 260281 ggcgggcgac gcaatattcg gcagaggagc cggctgtgaa taaggtgatc cggattcacc 260341 agcttgcgat agatatagac aatgtttccg ttttgaaaaa cggagagccg ctccagctga 260401 cgtcaacaga atggcagctg ctgtgcttat ttgcatcaaa tcctaaaaaa gtgtttacga 260461 aagaacaaat ctaccgttcc gtttggaatg aagagtactt tgatgatcag aacatcatta 260521 acgtacatat gcggcggctc agagaaaaga ttgaggatga cccctcctcc cctcaatata 260581 ttaaaacgtt atggggcatc ggttataaat taggagagtt ttagaatgac agtgctatgg 260641 gtggccgctg tcatcgctct ggcgtgtctg aatgtgattc aattcataat gaaaaagaag 260701 cgggacggga atctggctta cacggctgac cagcttagct acatgctcag ccgggattcg 260761 gcaggacaaa ttttgcttcc tacagacgat catgcgctca aagacttgct tgttaacatc 260821 aatcttatcg ttgagaatcg tcagcagatc agcgcccaat ttgccaaaac agagcaatcc 260881 atgaagcgga tgctgaccaa tatgtcgcac gacctgaaaa cgccgttaac ggtcattctc 260941 ggttatattg aagccattca aagtgacccg aacatgccgg acgaagagcg ggaaagattg 261001 ctggggaagc tccgccagaa aacaaatgaa cttattcaga tgatcaattc cttttttgat 261061 ttagcgaaat tagaatctga agataaagag atcccgatca ccaaagtaca tatgaacgac 261121 atatgcaaac gaaatatcct gcactattat gacgctgttc agtcaaaagg ctttcaagca 261181 gccatcgata tccccgatac gccggtgtat gcgcaggcga atgaagaggc tctggacaga 261241 atcctgcaaa acctattgtc caatgcgatt caatatggcg cggccggcaa gttaatcggg 261301 ctgacgctgt cttatgatga gaggaacatc gccatcaccg tatgggatcg cggaaaaggg 261361 attagtgaaa ccgatcagca gcgggtgttt gagaggctgt acacactgga agaatccaga 261421 aataaagcat ttcaaggaag cggcttgggt ttaaccatca caaaacggct tacagaaaaa 261481 atgggaggca tcatatccgt ccaaagcaag ccgtacgaac ggactgcatt tacgatcaca 261541 ttgaaacgca tgacatatta atcgtaagaa tttcttaagg tttgagaaat aaaaatgaca 261601 gggctcgccg ctacaataga aaacaggaaa agagagggaa ggagaaacaa agttgactta 261661 tatcgtacaa acaaacgggc tgaccaaaac atatcagggc aaagaggtcg tatccaatgt 261721 cagcatgcat attaaaaaag gtgaaatcta tggctttctc ggcccgaacg gcgcggggaa 261781 aacaaccatt atgaaaatgc tgacgagcct tgtcaaaccg acaagcggtg aaatcatcat 261841 ccttgggaac aagttcaccc acacgtcata tgaggtgctg gggaacatcg gcagcatgat 261901 tgaatatccg attttttatg aaaacctgac agctgaagaa aatttagatc tgcattgtga 261961 atatatggga taccacaata aaaaagccat acaagaagtg ctggatatgg tgaatttaaa 262021 acaaatcgac aaaaaacccg tcaaaacctt ttccctcggg atgaagcagc gccttggaat 262081 tgcgcgtgcc atcctcacga agccggacct gcttattctg gatgagccgg tgaatggtct 262141 tgaccctctc ggcattaaaa agatcaggca attgtttcaa gtgctgagca aagagtacgg 262201 gatgacgctg ctgatctcaa gccacctgct gggtgaaatc gaacaaatcg cggacacaat 262261 cggcgtcatt cgggacggca ggctgcttga agaggtatca atggaggatg tcaggggcca 262321 gaacactgaa tacatcgagc ttgtcacgcc gaatcagaca agggcctgct ttgtgctgga 262381 gaaagagctg caattaacca actttaaaat attaaatgag aaaacgattc gaatttacga 262441 ggctgaagcc tctcaggctg ccatatccaa agcattgatt ttaaatgatg tagacattga 262501 atcaatgaac aaaaagtata cgtcgctgga ggattatttt atcaaattga tcaacggcaa 262561 tagcatcagt gcgtaaagga ggagagacac gttgatgaat ttgatcagaa tcgaattaag 262621 aaaaatgaaa atgggctggt atatcagagg tgccctcatt gccaacgtga tcattatggg 262681 ttttatgtgg ctgatcagtt attccgaaaa agccgatggc ggggtttcgt tccaaagtac 262741 ggatgaagca ttcctcatca tcggcacctt cgtcagagcg gtatttatcg tatttggcgc 262801 tgtgctgatc gtaaaattgg tgatttcgga atataaaaac aaaaccattc ttgtgatgtt 262861 cacgtacccg atcagccgta aaaagctgct caccgctaag ctcatgatcg cgggcggact 262921 gacgtttatc acgattttac tttcaaatat actcatagcc gccggtttct tttggctgaa 262981 ctcgatctgc catttcatac cgggagagct tacttccgag atcatttctc aacaggcggt 263041 caaaatggcg gttttcgctt ttggcgccgc tggaaccagt ttagttccca tcttttttgg 263101 gatgcgtaga cactcggttc cggcgaccat catttcatct gtagtaattg tgatgctcat 263161 cagctcaaca agtccgggct tctcgatttc atctgttgtg tatatcccgt tatcgttagc 263221 ggcattcggt ttgttctttt cctacatggc gatcaggaat gcggacaagc aggatgcgta 263281 aacaaaggcg cccaatatgt ataaaaggcc gatgctgtca gcaccggcct ttccattatg 263341 agtctgttct tgtttcaaga taatgcttct tgccaatctc tttgctcatc atatagaaat 263401 ggaagcaata ttcaccgatt gccatgacga tcgcgccgaa taaagccgcc aatgcaactt 263461 caccgccagt catccccata gaaagcggca tgcccatcag ccagatcacg agaaaggcca 263521 aaccaaaatc agccaaagtt gcaatcatat tattccattt cggcaataca taaagatcgc 263581 ccagcaaata agaaataacc cctaacacaa tcgtcattag cagcgtatca ccaaacgtga 263641 aaccaaagcc cagaccaagc accagataca acacaataat cgtcataata cctttaatag 263701 cgagcgcttt cacatgtgtc attacaattc ctccttttgt catttgattt gttatgtata 263761 attcctcaaa tgtaaaaagt taaaccttat ttcttttcgg aggcgggtgc aaatctgctg 263821 gggagaggtc aatgatgtga atccaggaat tgaggctgcg gcgcttcgac agcggaaacg 263881 tgaagcttgt actgcaccgg acgctgcttt gatgcccaac agcccattat gtttgctgtt 263941 tttagatgaa taaatttaaa aacttctcct gtccctccgt catcacttct gaagtaatga 264001 aatatgatga aaagagatca aggggaggtg acgtgatggc ggtcgtgaga gcaacgagtg 264061 cggatgtcga tttgatggca aggctgctca gagcggaagc ggaaggcgaa ggcaagcagg 264121 ggatgctgct tgtcggcaac gttggaatta atcggctgcg ggcgaattgc tcagatttta 264181 aaggcctccg caccatcagg cagatgattt atcagccaca cgcgtttgag gctgtgactc 264241 atggatattt ttatcaaagg gcgcgagata gcgagcgtgc ccttgcacgc cggtcgatta 264301 atggtgaaag gcgctggcct gcaaaattta gtttatggta cttcaggccg cagggggact 264361 gtccagccca gtggtataac cagccgtttg tggccagatt taagtcacac tgcttttatc 264421 agccgacggc ggagacgtgt gaaaatgtat ataacacatt ttagagacag gacaccgttc 264481 aaattgaacg gtgtttttct ttgaaaagat gcaatgcaaa atattcctgt gagataatca 264541 aagaaaaaag agctgacgga gatgacagaa tggcaacaat tgacctgcaa aagaaaagtg 264601 taaagatcgt actggagaaa aagcagttaa cgaaggtgac ggctcgtgtt ggactggttc 264661 ttgatattac gggatcgatg agaccgctct acaaaaacgg gacggttcaa aatgtggtgg 264721 agcggatttt ggcagtggct gatcagtttg atgataacgg tttgctggat gtatgggtgt 264781 atgataatga attttcccga ttaaagccag tttcagaaaa ggatttttcg ggctatgtcg 264841 atcgtgaaat tttaaataat gaccgcttgc ataaattcgg cagaaatgat gagccgccag 264901 tcatgaagga cgtgctgcgc aaatatgtta cggaggaacc gagctcgtat cctgctttca 264961 ttgtttttat caatgacggg ggctgtaaaa agtcaatcaa accgataatt gaagcttctt 265021 ctgataaacc ggtgttctgg cagtttgtcg gcatcggaaa cggaaacttt gattttctca 265081 ataaactgga tacgttagaa gggcgtgtca ttgataacac gaacttcctg catatcgaag 265141 agattgaccg catttctgat gatgagcttt atgatgctct gcttgctgaa tttccatttt 265201 ggctgaaaga agcgaaggaa aaagggattg taagagaaca agagcctcct gctgaaaagc 265261 cgaaaaagaa gggctttttc agcagattgt tttcgaaata actgataaag agcactgagt 265321 cattctgcga aatggctcgg tgtttttgtt tttttaagat catgtgaaga aaaataggcc 265381 gaatgggcgg cttgcaaacg acaggatatg cagaaaacgc gtcattcagc cagctttcgg 265441 catgtttcag cagcaggctt gtgagggaag acctgttttt aatgttcagc gcttacaatc 265501 agttcacact tcttcacagt cgtttaacaa tgatttccta taatggagac gatcaatgag 265561 gagagagggg atcttgaatg gcatacgaca gtcgttttga tgaatgggta cagaaactga 265621 aagaggaaag ctttcaaaac aatacgtttg accgccgcaa atttattcaa ggagcgggga 265681 agattgcagg actttctctt ggattaacga ttgcccagtc ggttggggcc tttgaagtaa 265741 atgctgcgcc taacttctca agctatccgt ttacattagg ggtagcgtca ggtgatccgc 265801 tttctgacag tgtcgtgctt tggacacgtc tggcaccaga tccgctgaat ggcgggggaa 265861 tgccgaagca agcagtgcct gtcaaatggg aggtcgcaaa ggatgagcat ttccgcaaaa 265921 tcgtaagaaa aggcactgaa atggctaaac caagtcttgc ccattccgtt catgtggaag 265981 cggacgggct tgagccaaac aaagtgtact attaccgttt caaaaccggc catgaactaa 266041 gccctgtcgg aaaaacaaaa acactgcctg cccctggcgc caatgtgccg caaatgacct 266101 ttgcatttgc ttcctgccag caatatgagc acggatatta tacggcctac aagcatatgg 266161 caaaggaaaa gcttgatctt gtcttccatc tcggtgatta catatatgaa tacggcccaa 266221 atgaatatgt atcaaaaaca ggcaatgtcc gcacgcacaa cagcgcggaa atcattacgc 266281 tgcaagacta tcggaaccgt cacgctcaat accgttctga cgccaatctt aaagctgcac 266341 atgcggcatt cccttgggtt gtaacttggg atgaccatga agttgaaaac aactatgcca 266401 ataaaatacc tgaaaaagga cagtcggttg aagcattcgt gctccgccgc gcggcagcat 266461 accaggcata ctatgaacat atgccgctcc gcatttcctc tttgccgaat ggcccagata 266521 tgcagctgta ccggcacttt acgtacggaa acctggcgtc cttcaatgtg cttgataccc 266581 gccagtacag ggacgaccaa gccaataacg acggcaataa gccgccttct gatgaatcgc 266641 gcaatccgaa tcggactctg cttggaaaag aacaggagca gtggctcttc aacaatttgg 266701 gcagctcgac agcccactgg aatgtgctgg cgcagcagat tttctttgcc aagtggaatt 266761 tcgggacaag cgcaagcccg atctacagca tggattcgtg ggacggctac ccggctcagc 266821 gcgaacgggt tatcaatttc attaaaagca aaaatctgaa taatgttgtc gtactgacag 266881 gtgatgtaca cgcaagctgg gcatcgaatt tgcatgtcga tttcgagaag acaagttcaa 266941 aaatattcgg agccgaattt gttggaacct cgatcacttc cggagggaac ggagcggata 267001 agcgagcgga tacggaccaa attttaaaag aaaatccgca catccagttc tttaacgact 267061 atcgcggata tgtccgctgt acagtgacgc ctcaccagtg gaaagccgat tatcgggtga 267121 tgccatttgt gaccgagccg ggcgcagcca tttccacgcg ggcttcattc gtttaccaga 267181 aagaccaaac cgggttgaga aaggtatcat ccacaacaat ccaaggcggg gtgaagcaat 267241 ccgatgaggt cgaagaggat cgtttctttt cgcacaacaa agcccacgaa aaacaaatga 267301 ttaagaagcg tgcaaaaatc acgaattaag gagtggaaat tatgttttca aacattggaa 267361 taccgggctt gattctcatc ttcgtcatcg ccctcattat ttttggccct tccaagctgc 267421 cggaaatcgg gcgtgccgcc ggacggacac tgctggaatt taaaagcgcc acaaaatcac 267481 ttgtgtctgg tgatgaaaaa gaagagaaat cagctgagct gacagcggta aagcaggaca 267541 aaaacgcggg ctgaatgctg atgaggcaga caccgggtct gcctcttttt ttatgaaagg 267601 gagggctttt ttgaatggat aaaaaagaaa cccatctgat cgggcattta gaagagcttc 267661 gccgccggat tatcgtcacc cttgcggcat tttttctatt tctcatcacg gcttttttgt 267721 tcgtacagga catttatgac tggctgatca gggatttgga tggaaagctg gctgtgctag 267781 gaccgagtga aatcctctgg gtgtatatga tgctttccgg catttgtgcc attgcggctt 267841 ctatccctgt tgccgcgtac cagctgtggc gtttcgttgc accggcgctg actaaaacgg 267901 agcgcaaggt gacgctcatg tacataccag gtttatttgc gttgtttttg gcgggcatct 267961 ccttcggata ctttgtcttg tttccgatcg tgctcagctt tttgactcat ttatcctccg 268021 gccactttga aacgatgttt acggctgacc gctactttag gtttatggtg aatttgagcc 268081 tgccgttcgg cttcttgttt gagatgccct tggtggtgat gtttttaaca aggctgggca 268141 tcttaaatcc ttacagactg gccaaagcga gaaagctttc ctattttctg ctgattgtcg 268201 tgtccatatt gattacaccg cctgatttta tttctgattt tctcgtgatg atcccgcttc 268261 ttgtcctgtt tgaagtgagt gtcaccctat cggcgtttgt ctacaaaaag aggatgaggg 268321 aagaaacagc ggcggccgct tagtgcagcg taccacccgg tgacttcaca tcctcatcat 268381 attgtgcggc cgtaacagcg gcgattctca atgcccggac aatcgtgtcc aggctgaggc 268441 tcggcgctgt tttgtcgatt gtttgctgcg gaatgtaagg aatatgaata aaaccgccgc 268501 gaatgtgtgg ggatgtccgg ctaatgtgat ccattaaccc gtagaacaaa tagttgcata 268561 caaaggtccc cgctgtgtag gaaaccgcag ctggaatgcc gtgttccttc atcttagcag 268621 tcattcgttt cacgggaagc cttgtccagt aagcggcggg cccatctgga gaaatctctt 268681 catcaatcgg ctgatgtcct tcgttatcgg ggattcgcgc atctgcaagg ttgattgcca 268741 ctcgttccgg tgtaatctgc atccgtcctc ctgcttggcc gacacaaatt acgatatctg 268801 gctgatgttt ttgaatggct tggcgcagag tgtccagagc ggatctaaag acggttggaa 268861 tttgttccgc tgtaataatg gcttcttctg tctcgaagcc attaagccgt ttcgccgctt 268921 cccatgatgg attgacggtt tctttgtcaa aagggtcaaa gcctgtgatc agcacttttt 268981 ttctcattct cccatctcct ttttctttta ttctattgtt tatttatggg tttttcatca 269041 aaataatgta aaggagtgaa tcataatgga gcatttgccg gagcagtatc gccagttatt 269101 cccaaccttg cagacgcata cgatgcttgc cagctgttct cagagcgcat tggcagagcc 269161 tgtatcaagg gcgatccagg attattatga tagcctgctg tataaaggga cgaactggaa 269221 agaagcgatt gaaaaaacag agtttgcgag aaacgagttt gcaaagctga tcggggctga 269281 accggatgaa gtggcgattg tgccgtcagt ttctgatgca ctggtttctg tagcatcgtc 269341 cttaactgca tttggaaaga agcacgttgt atatacagat atggattttc cggcggtgcc 269401 tcatgtttgg caggcacact ccgattatac cgtatccgtc attccatcaa tagacggcgt 269461 gctgccgctt gaacaatatg aaacgcatat ttcggatgaa acagtactga cgtgtgttcc 269521 tcacgttcat tatcgtgacg gctatgttca ggatataaaa gcgattgccg agatttctca 269581 gagaaagggc tctttattgt ttgtagatgc ttatcaatca gccgggcata ttcccattga 269641 tgtgaaggaa tggggcgtag atatgctggc agcaggcacc cggaagtatt tgctcggcat 269701 accgggtgtg gcgtttcttt atgtgagaaa ggagctggct gacgcactga agccgaaagc 269761 atcagcttgg ttcggaagag agagcggatt tgatggggct tatgcaaaag tcgcgcgccg 269821 ttttcaaacg ggcaccccag cttttatcag cgtatacgca gctgcagcgg ctttatcgct 269881 gctgaatcat attggggttt ctcatatcag ggatcatgtg aaaacgatct gtgccgatgc 269941 agttcaatat gccgctgaaa aaggcctgca gctggcggcg gcacaaggtg ggattcagcc 270001 gggcatggtt gcgatccggg atgagcgggc atcggaaacg gcggggttgc tgaagaagaa 270061 aaaagtgatt tgcgcgccgc gggaaaatgt tatccgtctc gctccccatt tttataatac 270121 gaaggaggaa atgcggcacg cgattgatga aatcgcggcg aaaacgatcc acaagtaaac 270181 atgaaaaagc ccctgaacac tagtcagggg cttttcatat taatgatcta ctttaacgcg 270241 tttcataaag aaagcgccaa ttaaaccgat aatggcaaca atcattgcaa acacaaatgc 270301 gtgctgtacg cctgctgtca aagcttgcgg gatgactgcc ggatcggcag ggtttttaac 270361 tgtactcata taatcatgct ggcctgcagc cataatgctg accgcaaccg ctgttccgat 270421 agcgccggcc atttgctgca gcgtgttcat aatggcggtg ccgtctggat aaaattcacg 270481 cggcagttgg tttaaaccgt ttgtctgtgc aggcatcatg atcatagaaa tcccgatcat 270541 caagcaggtg tgcaggatga taatcagcac agctgttgaa gtggtcgtga catttgagaa 270601 gaaccatagt acaacggtga caatcacaaa tcccggaatg acaagccatt tcggcccgta 270661 tttatcgaac aagcggcctg taacagggga cataaatcca tttaaaatac cgcccggcaa 270721 gagaacaaga ccagatgcaa atgcagtgag gactaagccg ccttgcagat acatcggcag 270781 aagcagcata gatgacagaa tgaccatcat acaaatgaac accatgatca cacccaaaat 270841 aaacatcggg tatttgaacg cacggaggtt catcataggc tgcttcattg tcagctggcg 270901 gattgaaaat aagataaggc cgacaacgcc gacaatcagc gacacgataa cagtcgggct 270961 ggaccatccc ccggagcctt cacccgcgtt gctgaatccg aatacaatgc cgccgaagcc 271021 aatcgtcgac aggatgatag acaatacatc gattttcggc tttgtcgttt cagatacatt 271081 ttgcatatat gcgataccga aaacaagcgc cagcacaagg aatggaagag agatccagaa 271141 aatccagtgc cagttgagat gctccagaac caatcctgag aaagttgggc cgatggcggg 271201 cgcgaacata atgacaagcc cgatcgttcc cattgcggca ccccgtttat gaggcgggaa 271261 aatcaccaag attgtgttaa acatcagcgg cagtaaaaga ccggttccaa gtgcctgaac 271321 gatccttgcc gctaataaaa acgagaagct cggcgcaagc gccgcaatga atgtacctaa 271381 aattgaaaag ataagtgaca cggtaaaaag ctgtcttgtt gtgaaccact gcaacagcag 271441 tcctgaaaca ggaacaagga taccgagtac aagcaggtag cccgtcgtta accattggac 271501 ggttgccgct gtaatgttca attccttcat aaggtcggtt aacgcaatat tcagcgctgt 271561 ttcactgaac atgccgataa aaccggccaa cagcaaggaa atcataatcg gcatcacttt 271621 gtattgctga gatgctttag ctgttgtttc caaaatcatt tcccctctct atcaactgca 271681 tgtagtatgt cgtttttttt atctcttcag caggtcagga atgcagctgg agatatgaag 271741 gagcggcgta ctgttttttg ccgtcaaaga taaaaggatg ccgccttcaa tcatcgcgtt 271801 aaccacagtg ctggcttctt ttgcacggct ctcgctgcag ccagtctgcc gcagtttttc 271861 ctcatacaca gaggcccatt ctttgtaggc ttcatgacag gcttcgcgca acggttcgct 271921 tttcaatgac gtctcagccg ctagcaagcc cacaggcaag ccttcaatgt cttccgtaca 271981 tgaaaactgg caggagagct ccttcaaaaa ggcttgaatg ccttccgctg gatcggtgca 272041 ggcttccatg cagtccgcga ttttctgacg gatatactcc ttcatctcat tcacggcttc 272101 gatcgcaagc tgttctttac ccccgggaaa gtggtagtaa agagagcctt taggcgcgcc 272161 gctttccttt ataatctggt tcagccccgt gccgtaatac ccttgcagct gaaaaagccg 272221 ggtagctgcc gaaaggattt tctcacggga atctccataa ctcataacat tcccacctta 272281 ctgaattgca atcaaaaata tagtgactgg tctattatct tgattcaatc atcaattgtc 272341 aagaaaaatt cattgtatga aaagacaaaa aaagaaggat atgacaacaa aaaatactga 272401 gagaaaagct gactgatctt ttgactgaat agataaaatg tacaatgatt aatcatcata 272461 tggatgtaag gagagaaata gatgaaaaaa caacgaatgc tcgtactttt taccgcacta 272521 ttgtttgttt ttaccggatg ttcacattct cctgaaacaa aagaatcccc gaaagaaaaa 272581 gctcagacac aaaaagtctc ttcggcttct gcctctgaaa aaaaggatct gccaaacatt 272641 agaattttag cgacaggagg cacgatagct ggtgccgatc aatcgaaaac ctcaacaact 272701 gaatataaag caggtgttgt cggcgttgaa tcactgatcg aggcagttcc agaaatgaag 272761 gacattgcaa acgtcagcgg cgagcagatt gttaacgtcg gcagcacaaa tattgataat 272821 aaaatattgc tgaagctggc gaaacgcatc aaccacttgc tcgcttcaga tgatgtagac 272881 ggaatcgtcg tgactcatgg aacagataca ttggaggaaa ccgcttattt tttgaatctt 272941 accgtgaaaa gtgataaacc ggttgttatt gtcggttcga tgagaccttc cacagccatc 273001 agcgctgatg ggccttctaa cctgtacaat gcagtgaaag tggcaggtgc ccctgaggca 273061 aaagggaaag ggacgcttgt tgttcttaac gaccggattg cctcagcccg atatgtcacc 273121 aaaacaaaca caactacaac agatacattt aaatcagaag aaatgggctt cgtcggaaca 273181 attgcagatg atatctattt taataatgag attacccgta agcatacgaa ggacacggat 273241 ttctcggttt ctaatcttga tgagctgccg caggttgaca ttatctatgg ataccaaaat 273301 gacggaagct acctgtttga cgctgctgta aaagccggag caaaggggat tgtatttgcc 273361 ggttctggga acgggtcttt atctgatgca gccgaaaaag gggcggacag cgcagtcaaa 273421 aaaggcgtta cagtggtgcg ctctacccgc acgggaaatg gtgtcgtcac accaaaccaa 273481 gactatgcgg aaaaggactt gctggcatcg aactctttaa acccccaaaa agcacggatg 273541 ttgctgatgc ttgcgcttac caaaacaaat gatcctcaaa aaatccaagc ttatttcaat 273601 gagtattgaa gaaaagaagg cgaataagcc ttcttttttt tggcttttta ggaccaataa 273661 tgacctctga atcttaaaat ttctttaaaa ataagccaaa attacccttt acttaattaa 273721 tttggtaacg taatataatt ggagaatttg ttacaaaaaa aggaggatat tatgaaattt 273781 gtaaaaagaa ggatcattgc acttgtaaca attttgatgc tgtctgttac atcgctgttt 273841 gcgttgcagc cgtcagcaaa agccgctgaa cacaatccag tcgttatggt tcacggtatt 273901 ggaggggcat cattcaattt tgcgggaatt aagagctatc tcgtatctca gggctggtcg 273961 cgggacaagc tgtatgcagt tgatttttgg gacaagacag gcacaaatta taacaatgga 274021 ccggtattat cacgatttgt gcaaaaggtt ttagatgaaa cgggtgcgaa aaaagtggat 274081 attgtcgctc acagcatggg gggcgcgaac acactttact acataaaaaa tctggacggc 274141 ggaaataaag ttgcaaacgt cgtgacgctt ggcggcgcga accgtttgac gacaggcaag 274201 gcgcttccgg gaacagatcc aaatcaaaag attttataca catccattta cagcagtgcc 274261 gatatgattg tcatgaatta cttatcaaga ttagatggtg ctagaaacgt tcaaatccat 274321 ggcgttggac acatcggcct tctgtacagc agccaagtca acagcctgat taaagaaggg 274381 ctgaacggcg ggggccagaa tacgaattaa tgaaaaacaa aaccttgaag aatgctattc 274441 ttcaaggtta ttctgctttc agcacaatgg ttttcgcagc catatcatga acggtttgtt 274501 ttttcttcgt aaatgcggca gtcaaataga tcaggcggga gaacacatgc acccacgcta 274561 tcaggtaacg gacaatggct tgcgggaagg atattttttt atatgtttcg tccctcacga 274621 tttgcagccc gatgattttt ttgcctagtg tgcccttcca atttgtcagc ggcatcagca 274681 aagggtacac aatcagcatc aatatggcga caataatgac accggcggac ccatcgccaa 274741 acgtaaatcc ggctgccaaa atcactgctg cggcaatgat tacatcaagt aaaagagcgc 274801 aggcgcgcag catgaaacca gctagttcca atagaaacac tccttaaaat gttaaataaa 274861 cacctaatga ttgtaaaaaa gaagggccta aagtgggaat aggtgataag ccttaaatca 274921 caaaagttgg tgaaaatgtc ataggtaaat tggcataatc agccagctta tcacattacc 274981 aaattctttt ttagcccgaa accaagccct cagaagttat ttttgttaaa atagaaaagt 275041 tacaacagaa ttcggagggt ttattgtggg aaaagtgaaa cgaaatgccc cttgcccatg 275101 cggcagcggc aagaaatata aaaaatgctg cggaagtaaa gttgtcgact tcccggcgga 275161 actagcggca aaagaagcga aacaaattca ggaagactta gtggagtatg ccttcacagt 275221 acatagagaa agcatttcag gctttatcaa ccagcatgat tttctttctg ctatggacag 275281 acagacgaaa gacatcagcg tatttaactt aggaatctgg ggaatcttct tccacccgct 275341 tgctggtgag aagacaatct tcgaagagta ccttcagaaa aaaggcgatt cgatcactcg 275401 tccgaaaacg cgtgagatcg tagaatcatg gcagagcatg acgcctgctt tattgctgct 275461 gaaggacctg aaggaaggca tcattcactt tgaagatgtc attacggcaa aacaattcga 275521 agtggaaatg gacgccagca atcaagacct tcctccagtg ggaagcctga ttcttggata 275581 cccaatccac gaagcggaaa aagcagaatt cttcatgcag ttcacgatct tcccggtgaa 275641 gagaacagaa gcgctgatca gcaaggtgaa gaaatatgcg gatgccgctg tgaaggacgg 275701 caaaacgccg gaggacttca tgaagcagga attcaacaac gttctgttcg cgttgttagc 275761 tgagaaagat gaagagccac aagcagagaa agcggaagta agcactgttg agtgggcaaa 275821 cgacttggag aaagaaaccg ctgcggctat tgaagaaggc atgagcgggg aagagtatcc 275881 gactgaattg atcccagctg ttattgacat ctggaaaaca ttctgcgaga aaaaatcacc 275941 tgtcatcaga aagccggaag cttttgcggc ggcagttgaa tattatgtaa acgcaatttc 276001 tcttaacggc gcgtccgttt cccaggctaa actggcgaaa aaatacggcg ttagcgcatc 276061 aacgatttcc agccgttaca aagaaattga aagcacgctg caagatgaag cagatcgttt 276121 tgcacaagcg ttatcctcat aatggaaaaa accttgaaaa gccaggcttt tcaaggtttt 276181 tttatttctg aaacggaatt ttgatttcta accggaagat ggggtggcgg taggtaaaat 276241 ccagcctgcc aaaagcgccc ttcaccagtt tttgaatgat atatgtgccc atgccttcat 276301 gagcgccgtt tttcgttgag cggccaaacg attgataaat tgtatcgagc acttttgggt 276361 ccatcccggg agtgctgttt tcacaagtca gtacataaag cccgctgcgc agtgaagtct 276421 ccagtttaat ctctgctttt tctcgggcct ccgccgcgct gtcgagcgca ttttctaata 276481 tgttgccgac caagctgacc tgatcagcag gcgaaaacgg aagggaagaa agcggtgtat 276541 gcatatgcag cgaaacactc acattcgagg cgcgggcttt ttctaaaaaa tcataaagca 276601 cccctgcaac gtacgcgttc tctcctttca aaaaacggtc atattggctg tattgatccg 276661 cccagttttg aatatatgct tgtgtatctg ccttgggctg agctgatttg attgcagtga 276721 tatgtttcat tgtgtcatga ttccggcttc tgacatcaat cagcatttga ttggcgtgct 276781 gttcagcttg agtcagctta tcaatttgat cagaaagcct tgcctgcaaa gcagactgtc 276841 cgatacggag cccttcacac cctgcaaata tcgcgattac acataatacc ggcatgatgt 276901 ctgtgccaat caacaccact cccaccgaca tcacttgaat caccgcaatc cacgcacaaa 276961 gccctgagga acagtgtttc cacacccgct tcgtattcca aatgtacaat cctgcagcag 277021 ctgcgcctaa agcagcggcg agccaagagg cggctgtgct gtgtgaaaaa gcagcagctc 277081 cctgataaca tatgaaacta aataaaatca gataaagaca ttgaaaaagg gtaatcacgt 277141 actaaactcc tcaaaaatag tagttttgaa aataatcaag ctgctgctta gtgatcatcg 277201 cttttttaga cgttccctca aaggaaactg tgaatgaatg cttggtataa gcggaaaaat 277261 gctttatgta atgaatgttg ataataaagg aacgatgcga acgaagaaaa tctttttcgg 277321 gcaggtcgcc tttaatatca tttaatgttt gatacgtttg cacctcttcg gcggttgtca 277381 caatcgtcgt cgaacgtccc gtccgttctg cgaaaataat atccttcttt tgcaggacgt 277441 gcatttcaga cttttgcttt atcaatatac gcccattcaa actcgtttcc gttttctttt 277501 tcaagtaccg gtcgaaggaa gcggccagac ggtcggcata gtacggcttc ataatataat 277561 catggacgtt caggtcaaag gcgtgaaccg cataaccgcc gtggccggta acaaaaatca 277621 catccacatc aagtgaatgg gatttgatca aatcagcaag ctcgtagcca gacatatggg 277681 gcatctcgat atcggcaagc agcagatcaa tgtctccgtt ctttacccgc ctgtaggctt 277741 ccttcgctga atcggtggaa aagacaattt cgacgtcctg cattctggac acgatcgctt 277801 ctaacttctc taaatctact cgataatcat ctacaagtcc gacttttacc attatcattc 277861 ccctagttac atagaatcat ctttattcta tcccatttca cgacataaaa agaactcttc 277921 gcgacaactt tatccaacta atccagcttt tcgtatatag tcattactag aaataaagat 277981 aagggagatt gtgacatgat tacactgacc gattgcagcc gcaggtttca ggataagaaa 278041 aaagtagtca aagcggtgcg agatgtaagc ttaacaattg aaaaaggaga agtcgtcggc 278101 attctcggag aaaacggtgc cggcaaaacg acgatgctga gaatgattgc ttccttgctt 278161 gaaccatcac agggtgtaat cacagtagac ggctttgaca cggtcaagca gccggctgag 278221 gtcaaacaaa gaatcggtgt cttattcgga ggagaaaccg ggctttacga caggatgacc 278281 gctaaagaaa atctccaata cttcggcagg ctgtatgggc tgaaccgcca cgagatcaaa 278341 gcaagaatag aagatttatc gaaacggttc ggcatgcgcg attatatgaa ccggagagtg 278401 ggcgggtttt cgaaaggcat gaggcagaaa gtcgccattg ccagagcgct gattcacgat 278461 ccggacatca ttttatttga tgagccgaca actgggcttg atattacgtc aagcaacatc 278521 ttccgcgaat ttatacagca gctgaaaaga gaacaaaaaa cgattctttt ctccagccac 278581 attatggagg aagtgcaggc gctctgtgac agtgtcatca tgattcacag cggagaggtg 278641 atttaccgag gggcgcttga atcactatac gagagcgagc gcagtgagga tttgaattac 278701 atctttatgt ctaagcttgt cagggggatt tcttaaatgc tgagccatat ttataaaaaa 278761 gaaatgatcg acgctttacg cgacagaaaa acgatattac tcacaatctt agtgccgatg 278821 attatgatgc ttggacttgt ctttttttat gaaagcatgc tgtccgacaa aggggagcag 278881 tacacgctgg ctgtcggcca ttcgcttccg cccgcactgg aaagcaagct taatgagatt 278941 gacgaaatca gcgtaaaaac atttgcaaag cctgaagagg cagttgatga aggaaaagca 279001 gatgcctatc tgaacgtccc gaaagagttc gactcatatg tcaacagcat gacacctttt 279061 aaggttgatg tttacggcaa ttcaatcgat caagggtcgt caaatgccat gcagcttgtg 279121 cagtctgcct tagatcagta caaaaatgaa attgtgcagc aacgtttaac aaataagcat 279181 attgatcaat cggtgatcca gccgtttaca attcagcaaa aggaagcgga tgaggagaaa 279241 gggacttccg ctattatgct ttccgccatt ctgcccatgc tgattctgac ttccattgtt 279301 tccggcgcaa tgccgatcgc tcttgatatc atggccggtg aaaaggaccg aaagtcaatc 279361 gaggcgctgc tattaacgcc agtcagcaga aacaaagtgc tggtcggcaa gtggcttgcg 279421 gtttccactt ttggcgtggc ttcaggtgta tttgctttgg tgtttttgat tttgtccacc 279481 gtgttattta ccgaaaattt aaaaacggcc ttccagctgg gagatcatat gtggagtgta 279541 atcggcgctt cagccttaat cattgtgctc tctgcattgc tgatatctgc gatggagctt 279601 ttcatcagca tcatgtccag ctcggtaaaa gaagcgcaaa gttatatgtc tctcgtcgtc 279661 tttctgcctg tgttcccgat gtttttcatc ttcagcaagg caccgaacca atttgactta 279721 tcatactttc tcatcccgtt tctgaacctg catgcgttat ttaaacagct tttattcggg 279781 atggttgacc cggctaccat tttgtctacg tcaggaacca tcgccgtgct catcgccatc 279841 ttctttttac tagccagagc ctgcttcctg aaagacaaat gggttcttcc aaaataaact 279901 tgcgaaagga gaaatacact ttctcctttt tgtatatcct gaaaaaagaa ggaaaataga 279961 aaaaggatat ctaatacaaa aagtgaccct gcactatttt tcatcaaaat tggtttcaaa 280021 ggagaaggaa caatggatca aacacgtaca ctcggcaaaa cgaagctgaa ggtgaagcgg 280081 atcggattcg gcgcgaatgc ggtcggcggg cataatctat ttccaaatct aaatgatgaa 280141 acagggaagg atttagtgcg cacggcattg gatggcggcg tcaattttat cgataccgcc 280201 tttatatatg gattggggcg atctgaagaa ttaatcggcg aagtcgtaca ggaacgcggc 280261 gtgcggaatg agctcatcat cgccaccaaa ggagctcata aagaagtgga cggcagcatt 280321 gaattagaca atagccggga gtttcttcgc agcgaggtgg agaagagcct gaagcggctg 280381 aaaacagatt acattgattt gtattatgtt cactttccgg atggaaaaac acctctcgct 280441 gaagtggcgg gcactttgaa agagctgaag gatgagggga aaatcaaagc gatcggcgct 280501 tcgaacctcg attatcagca attgcaggat tttaatgctg acggctattt ggaggtcttc 280561 caggccgaat attctctcat acagcgtgat gccgagaaag agcttcttcc atactgtgaa 280621 aaacaaggca tctcctttat tccttacttt ccgcttgcgt ccggactgct gacaggaaaa 280681 ttcacgcaag acacagtctt tgatgatttc agaaaggata aacctcaatt tcagggtgaa 280741 acgtttatcc acaatctcaa aaaagtagat aagctgaaag cagtagcgga ggaaaaacaa 280801 gcggatacgg cacatgtcgc cttggcgtgg ctgttaacga gaccggcgat tgatgccatt 280861 attccaggag ctaaacgacc ggagcaatta caggataacc tgaaaacctt gaacattgaa 280921 ctgaccgaag atgaagtgaa tttcatcagc gacattttca aataaaaaag gaaatagccg 280981 tcatggctat ttccttttgg tgttttattc tttgatgaat gcttcgacta attctgctgc 281041 tctgtaatca tccatatcaa gctgccattg gtcgatgtca tttttcttca ttttcacttc 281101 aactgttttt tcagatgaag caggtccaag ctttttgaat tcctcaggat agacttgaag 281161 cgcgtatttc actgcctctt catagctggc actagagttt ttactgtagt agtctttcac 281221 tttgtcttcg atgcggtctg aaagagaaga tgcatctaca ggtttaactg tggcttcaac 281281 aattgcttcg tctttagaga ttgaagtcgt ttttgcttga atggaagagt ttttgcttaa 281341 tccctcttta atgccgttca cgatattatc aagcgctttg ctgtccgcat atgtgctgga 281401 aaggccggaa gctgagagat aaccgtcttt ggctgattca ttaaaatcat ttacaatttc 281461 atttttgtta gcgccggtga ttttttcgaa atcggcgtta tctttgccga aaagaaggac 281521 atcaacataa gctgataacg cttttgcaga atcttggagc ttatctgccg tcgccaggat 281581 ttttttgtct tttccgtcaa ttttaaaagt aactgatttt ggctttttat caccgtaaga 281641 ttccggcgta tagttaagct cgtattgctt gcctttatct acaacgaaga aaagatttcc 281701 ttcaacggat ttgtcagcgt taatcgtgct gccctgaagc ttttcgctat agtcttcagg 281761 gtctgtgtca gacattttgg tatcaccttg atacaatgtg aaatccatac tgtctacatt 281821 cagcgggtct tttcctgtgt ttttcaccgc gacattgact tttaacacaa gctggtcatc 281881 tgaagtggac ttatcatatt tagacggaag tgtgtaagag acatccttga ttttgacttg 281941 agctatatct gagctttttt ctgtttctga ttctttcttc tccgcgcttg ttttgctgcc 282001 ggaacaagca gctgtaaaca tcatcagcag aagaattagg aaaacagcgt acgttttttt 282061 ctgaaacatt catttttcct cctcaaatgg tttaggaaag gggagtcttt tgtctttgag 282121 aaatggatct ttttgaatgg attagcatca tataaccaaa aaaatcagtt cttttctcac 282181 ggttttcacc ggattttctg gaaactccgc cctcctttgt catgaatgga cctataaaaa 282241 gttacaacgg aattaatttt aagattatta gcttttatat tgaataggtt catcatccta 282301 tttttggtga aaaatgttct ggtaaaactg gtaaactcag aaaactgtgt attttagact 282361 attacttttt gattagttgg agggaactta agaaggatga aaggggccgc ctttgtgaag 282421 aaagagggac tgaaacaaaa agcactggaa atcggccggg tgccgacaca cttaaaactg 282481 gaaattgaag attatggcgg tgatgataaa agagctcatt tttgttgggc agatcctcag 282541 gatgagaata ccggcattat cgtggagctt ggaccggacg gagagctgga atccctttcc 282601 cgtgatattg agcctgaaag cggagaaagg ctgtctgagg agaaactaga ggatatcatg 282661 cgccaatttg tcgagactca tcatccgggg gcactctctg cctttgttcg tgaagaaaat 282721 gaccgtgcat acggcgataa agtgagattt tcatatgttc aaatggaggc tgggcttcct 282781 ctccccatga gcggatttat ggctgatgtt tccttatcag gtgagattgt ttacttccgt 282841 tattacggcg aagcgggcag catcatcaag ccaaagcggg tcgcggatgt tgaagaggca 282901 cttgccttta tcaagaagga cgtggagttc gaccttttgt ttgaggttct ccatcgttct 282961 gtttacaaaa acggagatga tcagccgcat ttggtgtacg agcctgaagg tagggcgatt 283021 accgtacctg cggatttggt tcaagaagaa caagcagttg atgatgacga tgattacagg 283081 gagccggaga gctttcctct ccctttattc gagggcatcc gcgaaaaggc cgatcctgac 283141 agcatgattg gtattgaaaa tgggtttgtc aaagagcggg aagcggattt gggagatggg 283201 agaattggaa tcgtttggcg gaatccggat gaccctgtgt atcagccggc ggataaaagc 283261 atggacagct ggtttaaggg acggactcat caagtgctga aaaccatcta taacaaagaa 283321 accggaaaac tcgaaggcgt catgtcattt atggagaaaa aagggccgct gacagtaacc 283381 ttggcagagt gtgaaaaaat cgcgcttcgc tttctatttg ctttatttcc gaatgccgat 283441 caatatttta ggatcagata cgacgaaaaa gatgaagaag aaaacgcagt cgctggtttt 283501 acgtttgaag cgcattgtca cggagttccg ctccgatttg ggcagatcag aatttgtgtc 283561 agccgccaga cagggtatat caccgtttat atgggaccgg atattgaccc aaataagctg 283621 gcaaccattg atcctgtgcc ggctatttca gttgaacaag ccaagtctat cttttggcag 283681 cattttaaag ttgagcttgg ctgggaaaga gagtacgggg atgatgaaga acacagctac 283741 cggctcgtct ataagccggt gtatccgcat tttatcgatg cacatacagg ggagcctgtc 283801 ttcagcatat ggtgaaacag ccaaaagtca cgcaattgcc tcagatatag aagagagtat 283861 gtgatgaaag taacagaaag aatctcaaaa aacaatgaca ataatagaaa aggacctttc 283921 ttcactttaa atgaagaaag gtctttttat ataataaaca ggattctctt tgtcgtagac 283981 tctttgaaag ggatgacttc attggttaat aaacagctga aaaagaaggc gcaggagatc 284041 ggaaatgtac cgacgcatta tgagcttgag atagaagatt acgaccaaaa gcaaaagaag 284101 tacgggcagg catattttat ctggaaggac cctaaagatc cggaaaagca cattacagtt 284161 gaacttagaa atgacggcgc cttgctcacc ttttcaacaa ctgtccactc cgagacagac 284221 aaaaaacttc cagatgccga gctgaagctg acggctcttc agtttgccgc tgccaatcat 284281 cccggcacat ttatgaattt tcattttcaa ggcaaggaag aaagggggca gcacatccgg 284341 tttgtctata ccaaaatgga gctggggctt ccgattccca attcaggctt tttaattgat 284401 atgacacgaa gcggtcagat tgtccacttt ctatattacg gggaagggca taaagccgaa 284461 gttccgacgg aatttgtagc aaaagagaag gttgtatccc attacttaaa cacaatgtct 284521 tttgagctga tgtacgatgt cattgatggc gaacaggaac caaggcttgt atatgaaccg 284581 attctaccgg gatacagcta tcccgcagat gtagacgaaa ttgtgcccga ccagcatatc 284641 gcagatgaaa gaatagaaaa cacggcgcca ctgccgccgc ttcagaacaa ggaagaagtt 284701 gatatatttg ccttgctggg ttttacctct gatatgcaga aagtcagtga aagagacttt 284761 ggagaacaaa ttggaagcac gtggcgcagg ggcgctgcgc cggagcgtaa ggatttaagc 284821 ataggaagct attttgaaac gagaaataaa aatacaatca aaatgaagac ggataaaaga 284881 accggaaaat taaaagcagc gctttctttt atggactggc ggaacaacct ccaatgctcc 284941 acggaagaat gccaagagat agcgcttcaa tttttgtatg ccctctatcc gagagcggct 285001 gagtttttca gggtgaatcc cgtccgaatt gatgaaagag ggagagtccg caaccatttt 285061 tctgtctggt ataaaggagt gccgctgcgg ttcggcgctg cccgcatcat tgtcaatccg 285121 gaaactgggt tgattgacgc ttttatggcg cctgatattg aacctgaaca attggaagcg 285181 ataaatcaca ggccggatgt ttccgctgaa gaagcgaaag aagcattttt agccgctttt 285241 gatgtgaaac tggaatggca gcctgatttt acagcaggca gtgaccagca ctgcaaactt 285301 gtctataagc cggtttaccc ttcctatatt gatgcgcaca taaggaaaaa gaaaaggctg 285361 tgaggggtgt ctagttagga atcatctcca agtgggggta gtccttgaat cgtttccaat 285421 ccccgcccca ttcgaaaccg agtgtcttag cgatctcgac aacctccagc caatctgatt 285481 ttccgttttg attgccgtca tattccatat cccatatgat gctgccatcc tttttttgaa 285541 gggcgaaatc aatcgctaaa ccatagttat gatacgattc ccctcctctt gcataggtga 285601 caatattccc tttttttgta cgtccctgtt tatataattc atcttgttcc ttaaaggacc 285661 tgaatccttc agtaatgacg acgtcaatgc ctttattcgc tgcagcggct ttgagtgcat 285721 cggcattctg cttcacaatc ggatgaagat ccgaggggac aggcatgtcc tgcaaggcgt 285781 tttgagaatg ccattcatgc cgaatataac taaaacaaag atctagaaga aatagaatac 285841 ataagataac aaatgttttt gcgggtaagt tcatatcggt ctcactttct caagatgtgc 285901 tgaatgttaa cgcttttaag tgattgactc tctctaaaag cgaacagcta tgataaaata 285961 taacataaat agtagcagga ggaaggaggc agaccgatga gagcaaagat tccatcagaa 286021 gaagtagcag taaagctgaa tgaatggtac aagctcattc gcgcatttga agcagatcaa 286081 gcagaagcgt taaagcagga gattgaatat gatttagaag atatggaaga gaatcaggac 286141 ttgcttttat atttttcttt gatggaattc cggcatcgaa tcatgcttga taagctgatg 286201 ccggtgaaag acagcgatac caagcctccg ttctctgata tgctgaacga aattgaaagc 286261 aatcagcaaa aactcacggg cttactggaa tactactttt attatttcag aggaatgtac 286321 gaattcaagc agaaaaattt catattagcg attgaccatt ataaacatgc cgaggaaaag 286381 ctcgagtatg tcgaggatga gatcgaaaaa gctgagtttc tttttaaagt cgcagaagtg 286441 tattatcaca tcaaacaaac gtatttttcc atgaattatg cgagccaggc gcttgatatc 286501 tatacgaaat atgaactgta cggtcgccgc cgggttcagt gtgaatttat catcgccgga 286561 aatttgaccg atgtgtatca tcatgaaaaa gcactgaccc acttgtgcag cgctttagaa 286621 catgccaggc agcttgaaga agcgtacatg atcgctgctg cctattataa tgtcggacac 286681 tgtaagtaca gtctgggtga ttacaaagaa gcggagggct atttcaaaac agccgccgcc 286741 atttttgagg agcacaactt tcagcaagct gttcaagctg tattttcact gacccatatc 286801 tactgtaaag agggaaaata cgacaaggca gtagaggctt atgaccgcgg gataaagagc 286861 gcggctgaat gggaggatga catgtacttg acgaaattcc gcctcattca tgagctgtat 286921 cttggaagcg gcgacctgaa cgtgcttaca gaatgctttg acctgctgga atccaggcag 286981 cttcttgctg acgccgaaga tctgctgcat gatacagcgg aacgtttcaa tcagttggaa 287041 cattacgagt ccgccgcttt cttttaccgc aggctgatga atattaaaaa gaagcttgcc 287101 gagcagcgtt ttcaatagga aatggcagag aactacaggt tctctgcttt ttttgtgctg 287161 ttttcaactc ggaaaaacag ggtattttcc actgcatagt gagaaacaga ggaggatatc 287221 aagtatgtac aaagatttaa ccggaaaaac agcgattgtg acagggtctt caaaaggaat 287281 cgggaaagcc attgcggaac ggttcggaaa ggagaaaatg aatgttgttg taaattacca 287341 cagcgacccg tctggagcag atgaaactct ggaaatcatt aagcagaacg gagggaaagc 287401 cgtctcagtt gaggcggacg tgtcaaaaga agaggggatt caggcgctct tggacacagc 287461 tttagagcat ttcggcacgc tcgatgtgat ggtaaacaac tccggtttta acggcgttga 287521 ggcgatgccg catgagatga gtcttgaaga ttggcagaga gtgattgatg tcaatgttac 287581 cggaaccttt ctgggagcga aagcagcact taaccacatg atgaaaaaca atatcaaggg 287641 caatgtgctg aatatctcaa gtgttcatca gcagattccg cgccctgtaa acgttcagta 287701 ttccacatcc aaaggcggca tcaagatgat gacggaaacg ctggcgctca attatgcgga 287761 taagggaatc cgcgtcaatg cgatagcgcc cggcaccatt gccacagaat caaatgttga 287821 tacgaaaaag gaagagagca ggcaaaaaca attgaaaaaa atcccgatga aagccttcgg 287881 aaagcctgaa gaagtggcgg cagcagcagc ttggctcgta tctgaggaag caagctatgt 287941 gaccggcgca acacttttcg tcgacggcgg aatgacactt tatccatctc agcttgaata 288001 gaagacaaaa cagggggatt gcgggatgaa aacagactgg tggaaggatg cagtggtgta 288061 ccaaatttac ccgagaagct ttcaggacag caatggagac ggaattgggg acttgcgggg 288121 gattatttcc cgtcttgact acataaagga gctcggggca gatgtgattt ggatttgccc 288181 gatctatcct tctccgaatg ttgattacgg ctatgatgtg acaaaccata aggcgattat 288241 ggattcttac ggaacaatgg acgattttca cgagctgctg gaccaggtgc atcagcgggg 288301 attaaagctg gtgatggact ttgtgttaaa tcacacctcg gtcgagcatc cgtggtttaa 288361 agaagcggag ctggacaaaa acagcaaata ccgtagctat tattattggc gtcccggcac 288421 aaagaacggc ccgccgacgg actggctctc aaactatgga tgcccggtct ggcaatacga 288481 agagcacacc ggagaatact atctccatat gaatgccgtc aaacaagctg atttaaactg 288541 ggaaaatccc gaagttcgcc aggcggtgta tgacatgatg aaattttggc tcgataaagg 288601 ggtcgacggt ttgcgaattg atcagctcca tctcatttct aagaaagaat atcttccttc 288661 gtatgaggac tatatcaatc agcaggcaga gccgaagccc tttcagccaa atggcgaacg 288721 aatccatgac tatttaaaag aaatcacaga tgaagtgttt tctcattatg atgtcatgtc 288781 tgtcggagag gtcggcagtg tcacaccgga agaaggcctg aaatatacgg gaacagataa 288841 gcatgagctg aatatgattt ttcactttca gcatatggag cttgatcagc agcccggaaa 288901 agaacattgg gatttgaagc cccttgagct ttctgattta aaatcggttt tgacaaaatg 288961 gcaaaagaag cttgaacatc aaggctggaa tacattgttt tggtgcaacc acgaccagcc 289021 ccggattgtg tccagattcg gagacgatgg ggaataccgc aaagcatcag cgaaaatgct 289081 ggcagccgta atttatttta tgaagggcac gccgtatatt tatcagggag aagaaatcgg 289141 gatgacaaac gcgccgttca cccggattga agactacaaa gatatccaaa cgatcaatat 289201 gtatcataaa cgggtgtttg aaaaaggcta tgatccaaat gatgtgatga gatcgatctt 289261 agccaaaagc cgggatcacg cccggacccc gatgcagtgg aacagcggca aaaatgccgg 289321 atttactgac ggcacgcctt ggctgaaggt caatccgaac ttcaccgcaa tcaatgtgga 289381 ggaagcgcag ggagatcctg attctgtctt aaactattac aaaaagctga tcagcctgag 289441 aaagcagtac gctgacctca tgaaagggag ctttgatctt ttgcttccgg acgatccgca 289501 gttgtttgta tacatgagag aaaacagtaa acaacagctt ttgtcggtca ataatttttc 289561 aaaagagcag gctgtttttc agtggcctaa gaactgcggc aaagctcagg cctcactgct 289621 tctcagcaat tataacaacg atgatcttga tgacgaaatg gtgttccggc cttatgagag 289681 cagggtctat cttctggaca aaacaaacta atgattgaag tagcccggca tttttagccg 289741 ggttttttta gtacatatat tcgctctgca ggcgggaaga ataaatgaaa atgaaattta 289801 ttcttgcaaa acgtaatgac ttcggtttat tatgatatag gattacaaaa tcgttatcat 289861 tttgatttaa agttactgaa aaagagggga tatacgatat gtttaaaaaa tggagcggtt 289921 tgtttgtgat tgcagcgtgc tttttattag ttgcagcatg cggcaactca tcaacaaaag 289981 ggtcggcgga ttcaaagggt gataaactgc acgttgtcac aacgttctac ccgatgtatg 290041 aattcacaaa acaaattgta aaagacaaag gcgatgtgga tctgttaatc ccatcttccg 290101 ttgaaccgca tgattgggaa ccgacgccga aagacattgc caacattcag gatgctgatt 290161 tgttcgttta taatagtgaa tacatggaga catgggttcc gtcagctgaa aaaagcatgg 290221 gccaaggcca tgccgttttc gttaatgcaa gcaaaggcat tgatttaatg gaaggctctg 290281 aagaagaaca cgaagagcat gatcatgggg agcatgagca cagtcatgca atggaccctc 290341 acgtatggct tagccctgtt ctggcacaga aggaagttaa aaatattacg gctcaaatcg 290401 tgaagcagga cccggataac aaagaatact atgagaaaaa tagtaaagaa tatattgcaa 290461 aactgcagga tcttgataaa ctatatcgta caaccgcaaa aaaagcggag aaaaaagaat 290521 ttatcacgca gcatacagct tttggctatc tggcaaaaga atacggcttg aagcaggttc 290581 cgattgcagg gctttcacct gaccaagaac cgagcgcagc cagcttggca aagctgaaaa 290641 catatgccaa agaacataat gtaaaagtta tttactttga agaaattgca tcctcaaagg 290701 tcgcagatac gctcgccagt gaaatcggcg cgaagacaga agtgctgaat acactggaag 290761 gcttgagcaa agaagaacag gataaaggtt tagggtatat cgacattatg aaacaaaacc 290821 tcgatgccct gaaagattca ctattggtta aatcataaga tagtgtgcgc cggaggggtg 290881 cacactattt ctttgtgaga aaggaagatt aacatgaatc tcgtctcatt gaaagatatc 290941 gttttcggct attcccatac gcctgtttta gataaagtat cacttgatat tgaaagcggt 291001 gagttcgtcg gcatcactgg accaaacggc gcctctaaat cgacgctcat aaaggtaatg 291061 ctcggcatgc tgaaaccgtg ggaaggcaca gtgacgatca gtaaaaggaa tacagaaggg 291121 aaacgcctga ccatagggta cgtcccgcag caaatttctt catttaatgc cggatttccg 291181 agcacggtgc tggagcttgt tcagtcaggc cgctatacaa aagggaaatg gtttaaacgt 291241 ttaaatgaag aagatcatct tgaagtagaa aaagcattga aaatggtgga aatgtgggac 291301 ctccgccatc gtaaaatcgg tgatttatca ggcggacaga aacagaaaat ctgtatcgcc 291361 agaatgctcg ccagcaaccc ggatctgctg atgctggacg aaccgacgac agctgttgat 291421 tacgacagca gaaaaggatt ttacgaattt atgcatcatc tcgtgaaaaa tcacaaccgc 291481 acagttgtga tggttactca cgaacaaaac gaagtacagc aatttttaga taaagtgatt 291541 cgattagaga gaggagaaaa aggcggatgg aaatgtttga cttggaattc atgcgacgag 291601 cttttctagc aggcggcatg atcgccgtca tggctccgat actaggagtg tatctcgttc 291661 tcagaagaca ggccttaatg gctgacacac tttcacatat ctcattgtca ggtgttgcca 291721 tcggcttttt tctcagcacc aatataaccg cagcaagcat agtcgtcgtg accatcggcg 291781 cgatcggaat tgaatacatg cggcgggcgt atcggactta ttcagaagtg tccattgcca 291841 tcttaatggc agctggtttg tccttcgcga tgtttttaat cagcctttcc aaaggcacag 291901 ccaatatgag catcgatcaa tacctatttg gatcgcttgt gacagtaaac cagcagcagg 291961 tctatattat cagtattatc acactgctga tcctgcttta ttttattgta ctgagaaggc 292021 cgctctacct gctgacgttt gatgaagcta cagccaaaac atcgggaatc aatacaaacg 292081 ttctctcgtt gtcattcagt attgtcacag gccttgcgat ttcagtcatt attccgatca 292141 tcggggtcct tcttgtatcg gccctgctcg tattgccggc agccttcgcc atcagaattg 292201 caaaaggctt taacatggtt ttcattacag ccatactcat ttcattattc agcgtattta 292261 cgggactgac atcatcctat cagctcggga cgccgccagg tccgtctatt accctgctat 292321 tgatcgtttt gctattaatc ggatttgcag ttcagggagt ttggacgttt atcaaaaaag 292381 aagctcagcg caaaaaaaga agccgataac atgaaaagca gttttcccta gggaaaactg 292441 ctttttttat agaaacaatt cggcaaggcg ctcataagat tcttttttcg cctcaaaatc 292501 aaacacattg cacagaacca tgatttcatt tgtttcgtag cagcctgtga ggtctaacag 292561 ctgttgtttg acagtggtgg gagaaccgat caccatccgc tttctgtttt cttctatgag 292621 ttttttatcg gacgctgtat agggatgagc tttcgcttcc tcgatgcttg gcacgcggct 292681 gtccaagcct tttccgacgc gaagaagcca cagatcctgg cttaatgcga gttcttctgc 292741 ctcttcatct gtttttgcgc aaatgacaaa aatcgtaaac agtgcggatg gattcgaaaa 292801 atgggctgag ggccgaaagc tttcccggta gatgcggaat gcattttctc ctcgctcggg 292861 attaatgaaa tgcccaaata catatccaat cccctggtgc gccgcgcgtc ttgcgctgtt 292921 ttcaccaaga ccgagcaccc atagctcggg tgccgtacca ataaggggcg ccgctttgat 292981 tccggcatac ggatggtcgg gaggaaggga atctgttaga aaataagaga catcctgcag 293041 ctgtctgtta aattcggtta agcttttttt caccccgtcc gttaatgcaa gtctggtttt 293101 tgtcgtgccg ccgggggagc gaccgacgcc gaggtcaatc cggtttggat acagggcctc 293161 aagctggcga aaggtttcag ccactttaaa tgggctgtat tggggcagaa gcacgccgcc 293221 tgatccgaca cgaatggtgt ttgtctgtgc tgcgatgcgg gcgatcatga tttcaggcgc 293281 tgtgcttgcc agtcctttcg tgctgtgatg ctcggcaaac caataacgct tatagcccca 293341 ctgttcgctt aattgggcaa gctcaaccga atgctggaga gttgtcacag ggctttctcc 293401 tttagaaaca ggtgcctgat caagtatgct taaatgaatc aaaaggccgc ttcctttctg 293461 tctgttttta gatggtgaca ccagaatagg caaaatgact tgcccgcgtc aaatggtttg 293521 tttaagaagc gcactttata gcatttgcaa atcatatatc aaatatggaa gttttttttc 293581 gaggtttttc gtcaattatt cttaactttt acgaaacttt gatataataa caaacgtata 293641 tattagtaat ttacggctta ttttccttgt gagcgtaaaa ataaatgtga ctatcttcac 293701 attttgatga gtaggagtga atcgtgtggc aatttcttta gaaaaaggtc aacgaattga 293761 tttaacaaaa ggaaaagccg gtctgtcaaa attgatggtc ggtctcggct gggacccagt 293821 gtcctcaggc ggaggattct tcagcaaact gcttggcgga ggcggtccga atatcgactg 293881 tgacgcttca gtgctgatgc tggaaaacgg aaaattcacc gataagaaaa acctgattta 293941 tttcggcaac ctgaaaagcc gctgcggcgg tgtacagcat acaggcgaca acctgacggg 294001 tgacggtgcg ggcgatgacg agcaaattat gatagattta gataaagtgc ctggaaacat 294061 cgataagctt gtatttgtag tgaacattta cgattgtgtc agaagaaaac aagatttcgg 294121 catgattcaa aatgcgttta tccgcgtagt tgatcaatct aatcacgagg aaatgctcaa 294181 gtacaatttg agagacaatt acgccggcag aacaagcctg attacagcag aaatctaccg 294241 cagcggcagt gagtggaagt ttgcggcggt cggtgaaggc acaaacgata cgagattaga 294301 agatattatc agtcgatacg tataaaagaa aaggagtgga tgaaacatga caatttcatt 294361 ggcaaaagga caaaaagtag atttaacaaa aacaaatccg ggtctttcaa aggttgttgt 294421 cggtttaggc tgggatacga acaagtatga cggcgggcac gactttgatc ttgactcaag 294481 tgtgtttctg ttagacgccg cgggcaaatg cgcgtcacca aacgacttta ttttctacaa 294541 ccagcttgaa ggcggcaacg gttcagtcgt tcattcaggc gacaacctga ctggtgctgg 294601 cgaaggcgac gatgagaatg taaaagtaaa tctcagcgct gtaccggcaa acattgataa 294661 aatctcattt gttattacca ttcacgatgc agaagcgcgc agccaaaact ttggacaagt 294721 atcaaacgcg tttgtccgca tcgtaaatga agaaacaaat gaagagctca tccgttacga 294781 tcttgcagaa gatttctcta ttgaaacggc aatcattgca ggggagcttt acagacataa 294841 cggcgagtgg aaattctcag caatcggctc aggctaccaa ggcggccttg cccgcattgc 294901 aacagactac ggtttgcaag tcggttaaga caaatacgaa gagcagaaag gagagaggca 294961 gtatggccat tcaattatca aaaggacagc gcattgattt aacaaaaaca aatccgggac 295021 tgactaaagc ggtgatcggc ttaggctggg atacaaacaa gtactccggc ggacacgatt 295081 ttgacctgga tgcttcggcc tttttagttg atgcgcatga taactgcgta aatgatctcg 295141 atttcgtctt ctataataac cttgaacatc cgagcggcgg tgtcatccat acgggtgaca 295201 accgcacggg tgagggcgac ggagatgatg agcagattat cgttgatttc tcaaaaatcc 295261 ctgctcacat tgagaaaatc ggcatcacag tgaccattca cgacgctgaa gcacgcagcc 295321 aaaactttgg acaagtttcc aatgcatttg tccgcgttgt ggatgaagaa acgcagaatg 295381 agcttcttcg cttcgatttg ggagaagact tctccattga aacagctgtt gtcgtttgtg 295441 agctttacag acacggcggc gagtggaaat tcaatgcaat cggcagcgga ttttccggcg 295501 ggctggctgc attgtgccgg aattacggtt tgcaagtgta agcgagtgac aaatagagaa 295561 gtcaccgttt caaattatag gaggaaaaaa cttggacttt ttacatcata ttttgtctac 295621 gtatgcttca tttttcgatt ggaaaatgtg gggggaagtt ctgactgatc ctgtttcctg 295681 gggtttgatc ggttcccttg ttgttctgga aggcctttta tcggccgata acgcgcttgt 295741 tcttgcggtc atggttaaac acctgccgga aaaacagcgg aaaaaagcgt taacgtatgg 295801 tttgtttgga gcttatattt tcaggtttat tttcatcggg ctcggtatgc ttctcattaa 295861 attctggtgg atcaaggtgc ttggcgcgct ttacctggct tggctcgtca ttaagcactt 295921 ctggataggc gaaaaagaag aggaagcgga cggcatgaag aaaaactctt ggatggtccg 295981 cacgttcggg atcttctggg cgactgtcat ttcagtagaa ttaatggatc ttgccttctc 296041 tgtggacagc atcctggccg cgtttgcagt atctgaaaaa gtatgggtgc ttctgattgg 296101 cggtatgctt ggtattttaa tgatgcgtac agtggcaaaa gtgttccttg tgctgattga 296161 taaaattcct gagctggaaa acacagcatt cgtcttaatc ggcattatcg cgctgaaaat 296221 ggcggggagc gctttccatt acgaaatgcc gcactctgta ttcttcatta tcattatcgc 296281 tgcatttgcg gtaacattga tcattcacta catcaataaa caaaagcagg tgcgcgaaca 296341 aacagccgct tcaaaagaag aataaaacaa aacaaggagg gaggttcaat gtccttcctt 296401 ttttgttacc gaaatatcgt ttcaatgaca aaccggaaag gaggatatga tgagacaaga 296461 agaactaacc attcataaag cacttccggc tgatggcgat tggaaaagcc tgctgtttca 296521 gccattgccg gagcgggatc actatgaaac tgcacaaggc ctttcttttt ctcgtcttgc 296581 cggtcagata ttgggcacgc ctattgatga gacggactac tataacgagc tgtatgagct 296641 gtctgtaaac gaccgcataa cgattttgag tgaaacgctt gataaaacaa tcgaaccgga 296701 aacatttcaa aagcttcagc atattcattc catcaatcag aaagaaaaag ggctgtcagt 296761 cagccgcttt gttgcctttc tggacgggga aaagctgatt gcgaagcact caaatccctt 296821 gatgcaccgc catttaagaa aagcgttgat gacgctttta catacctttg cggacagtca 296881 tgaaaagggg ctgaatcatc ctgattttcg cagagtgctg cttgatgtct cgaagttttc 296941 cttaaaccat ctgaaccctt ggctggaaaa aaccgatata gagcgggaga tgccgaaggt 297001 tgtttggtat ggagatgcga cgaaaagcca gctctatttc ttatattatc tgatgctggt 297061 cggctgtgat gtactgctgt tccatccggc gggaacggat cagctggcgc ttgtcgaccc 297121 gaagcaggag ctcggtttta cggaaaagct cccggatgtt tcggagcttc agccgtttcc 297181 gaaagaaaaa ccagaccgga aatcaacagt ggcttaccgc tcaacaaagg aaattgaaca 297241 tgtgctgaat cacgaggaat ccatgctata taagccgtgg cagttcagag atcacacacc 297301 ggtgtccgtt acgctgaaaa cgacctatga tgaattgttt ttaatcacga aagaacgcgc 297361 ctttattcgg ccgaatttca aagctgataa acattccatt gagattccga atgtattcgc 297421 caaaattatg ggcgtgtcga aagacaataa ggaatattgg aacaggcttc atactctagc 297481 ggattatcag gaaacagaaa tggtcagaag ctttccattt acagaagaaa taaagtcgaa 297541 ctatcaattt cactacagcc acgcacttga tcaagaaggg aacattgatc cggacaagct 297601 gatggcaagc aatgtgtggc agtacaaaca gctgccggcg ggcgttcaga ctgccattgc 297661 caaaacgatt tcgagaatgt gcaggtaccc gcggcttaaa gccttgcatc aggaacaagt 297721 caaggatgtt caaatctatt tgtttaaaca aacaacaaac ctgcctgcta atctgctgaa 297781 attgattcaa atgttcgact atgcgcaaac cgttccgaaa ctcgttttat atcatacgga 297841 aatgagcggc ggactcacgc gttcggatgc tgccgccctg ctgttcctga atgaaatcgg 297901 aatcgatatc atcatttata atccgcccgg acaccaagat attgagcagt ttattgaaga 297961 ggatcagtat gatatccact ggctggatga catggtgttt cagcaggact acaaagagcc 298021 ttcgcttgtg aaaaggctct tcagaaccat tacccaaaaa taaggagaga agaaaagcat 298081 gacaacagaa aatcaaaatc cgcttgttct cgataaaaat gaagagattt cccagcaaaa 298141 agctgacgat atccgtcttc agctccgtca ggaaccagaa gtgaagcggc ttgctcaaca 298201 aattgacgtc aaaaaccaaa tggagctgct tgagtacggc aaggagccgg ccgttgaaat 298261 atccaagttc tctgaccgca tcttggggat gatgaaaaca acaagcgtga cagactccgg 298321 cacaatgctg actcagcttg ggaaaatcat ggaccgcttc gacaaaaatg attttgatga 298381 gccaaaggga ttaatggcga aaattttcaa acgcggcggc agcatgattg aaaaaatctt 298441 taaaaagtat cagacgcttg gcggagagat tgaaaaaatc cacgttgaga tttcaaaata 298501 caaagatgag atgacgaaga cgaactacac gctcgatgaa atgtatgaaa acaatatcaa 298561 atactatatg gagcttgaaa aatacgtcgt tgccgggcag atgaaactgg aagagatgca 298621 gtcgatcctt ccttcatatg aggaaaaagc ggcaagcggg aaccagctgg cgcaaatgca 298681 gctcgatacg ttgcgcaacg gcattcaggc gcttgaggaa cgggtgtatg atcttgacat 298741 ggcacggatg gtggcgcttc aaaccgcacc tcaaatccgt ctcctgcagc gaggaaatgc 298801 aaagctgatc gggaaaatca actccgcgtt tatcattacc attccgattt tcaaaaacgg 298861 cattattcag gctgttacgg taaagcggca aaagcttgtg gctgattcca tgagcgagct 298921 tgaccgccgg acaaacgaga tgctgaaacg aaatgctgaa aacatctcga gccaaagtgt 298981 tgaaattgcg agaatggccg gcagaccgag catagatatt gaaacgattg aatcgtcttg 299041 gaacacgatt gtcagcggca tgcaggaaac aaaacaaatc gaagaagaaa acaagcgcct 299101 ccgcgaagac ggcgcgagac gaattgccca gcttcaggat aatattaaaa aagcagcatt 299161 gcagcaataa taaaaacccc gcttgtggaa cataagcggg gtatttcaat tacatcattt 299221 agttaatgac aatgtgtaaa gacaggtgta aacttaaacg gtaatcattt tgcatatcag 299281 aggtgttggc aatgggaaaa caacagccta tatcccagcg taaactgctg ggcgtcgccg 299341 gtttggggtg gctgtttgat gcaatggatg tcggaatatt atcgtttatt atcgccgcgc 299401 tccatgtaga gtggaatctg tcgcccgaag aaatgaaatg gatcggaagc gtcaattcca 299461 tcggcatggc tgcgggtgcg tttttgtttg gtttgcttgc tgatcgaatc ggccgcaaaa 299521 aagtgttcat catcaccctt ttatgctttt ccatcggaag cggcatttcc gcttttgtga 299581 cgagcttatc ggcatttcta atccttcgtt tcgtgattgg tatgggactt ggcggcgagc 299641 ttccagtcgc ttcaacactc gtttcggaag cggttgtgcc tgaaaagcgg ggcagagtga 299701 ttgtgctttt ggaaagcttt tgggccgtgg gctggctcgc agcggccttg atttcttact 299761 ttgtgatacc aagcttcggc tggcaggctg cccttctgtt aactgcgctg actgcttttt 299821 atgcgctgta cctgcggacg agtctacctg attcgccgaa atatgaatcg ctttctgcca 299881 aaaagaggtc gatgtgggag aatgtaaaaa gcgtctgggc aagacagtat atacggccga 299941 cggtgatgct gtcgatcgtt tggttctgtg tggtgttttc ttattacggc atgttcctat 300001 ggctcccgag tgtcatgctg ctgaaaggct tcagcatgat tcaaagcttt gaatatgtcc 300061 tgctgatgac gcttgctcag ctacctggct atttctctgc cgcatggctg attgaaaaag 300121 cgggccggaa gtggatactc gtcgtttact tgattggcac agcaggaagc gcctatttct 300181 tcggaacggc ggattcctta agtcttctgc ttacggctgg agtgctgtta tcgtttttca 300241 atctcggtgc gtggggcgtg ctgtatgctt ataccccgga gcaatacccg actgcgattc 300301 gagcaacagg ttcaggaacg acagcagcgt ttggaagaat cggcggcatc ttcgggcctt 300361 tgctcgtcgg aaccctggca gcccgtcata tttcgttttc ggtcatcttt tcaatctttt 300421 gcattgcaat cttacttgcg gttgcttgta ttttgattat ggggaaagaa acgaaacaaa 300481 ctgagctaga ataggaaaag cacctcttaa aagaggtgct ttcagcgtgt cgacaaaccc 300541 tcgcattcgt tgtcaggact gcgcttcggt gctcaatgcg aagtggatca acggctaaat 300601 tctcaggcgt cctgcctaaa cgccgtcgtc atcacatcct gtgaatgtcc gctcctatgc 300661 tcgtccttcc tagacttcaa gggttttcaa tcacgctgaa aagattttgt caacaatctg 300721 aggcacctct tgaatgaggt gcttttttac aattgcgccc gggctgtgga ttggcgtttc 300781 ccggttttac tgattgtctg gtagagcgtc atagaaagta tgaacagaat ggcagtaaat 300841 cctgtgacag ctccgaaatg ctgtgtgctt tgatataaaa aacctgcaat acttgtaccg 300901 acagtggttc cggcatacat agcggcattg gaaagggaag cgatggttcc tcgcgcattt 300961 ggtgcaatgg attgaaagac acccatcatt aacggaaaga tgatgccagc tgtaaagaac 301021 gtgagaaaaa agccggcttc tactaaaaac aagtttggaa agaacggaag agcgaaatag 301081 agagcgccca ttagcagcat cccgctgatc agtgttttaa acatgcccag cttttctgaa 301141 acccggctgc cgataaggct cccgagcata tttcccagtc cgagtacaag catagctgcg 301201 ccaatttgtg acacggttaa atgataatcc gcggaaagcc aagtacccag aaagctgaac 301261 gatgcgaagt ttccggtttg aaacagaaaa taggcaagca gaatgaccga tgttttcggc 301321 aatgaaaaaa gctcccgata ggggttgaca attgatgggc gcgccaatgg ttcagaaggc 301381 cggatgccag gcatgaccgc cgccaggatc aatagaagaa taagcgagca cgctgacaaa 301441 acgaaaaatg gcgtatgcca tgtaaaggaa gcgagaaacc ctccaatagg aagtccgagc 301501 atttgtgaag cggccaaacc tgctgtcgca atccccatgc cttttatgat ctgagaaggc 301561 tggacaatga ctgggatgga cgcccaaatt tgaggcgtca caaacgcagc gctaacgcct 301621 gcggcaaaac ggaacaggca catggcggca aaagagggag cgatgccgca taaaaatgtg 301681 gatacgataa agcctgcaag tccccacagc atgactgttt tcctgttcag ccggtctgag 301741 attgggcctg caatgaaagc gaagagtgca taaccgagtg cataagcact gaccatccag 301801 cctgacaaat cagtagagac atgaaactga tcctgtaaaa gggggagaag cggcgaaagc 301861 aaaaaggtat ccgtgccaat gacaaacatg acactgaaga aaagccaaat gcgattcaaa 301921 ttttatcact cctattgttt tataacttta aaactatgaa acagatatgt atagagaaaa 301981 ccctttgtta gagggtttcc aaaaagccag gcaggtatgt ttgaaatgtg tcttcacgca 302041 gactgacgta ttttgtccgc gaatctttcc gggttgccgt caatcccgct tcacgcagcg 302101 ttttaaaatg ataagatgcc gtggttttga caatattgca cttttcacct acttcaccgc 302161 agctgagttc ttttccgctg acataaagcg tacgaataat ggcaagcctt gattcatcag 302221 acagtgcttt aaaaatttgc gctctgattt gatcatctga ttgtttcata gtcatgaaac 302281 tataatacat aatgggtgtt gaaaaagcaa cttatttttc cagtaaagga gcaggaagtc 302341 ataagaggaa ggaggaattc aattccaata aaagcgtttt caactaaagg taggagaaaa 302401 atcacccgta aaatacaatc atataggagg attacagagc atttagaagc ataaataaga 302461 tcatgtggtc acatggatgt ttataaagaa atggtacaga ataaaagaga atatgctgtt 302521 tgtgtgggaa gttacataaa tgttacggta ataaagattg cttaatatgg agggaaaata 302581 tgagtgtaga tgagaaacca attaagataa aagtcgagaa agtctctaag atttttggga 302641 aacaaacaaa gaaggcagtt caaatgcttg ccaacggaaa gacaaaaaaa gagatcctga 302701 aagcaaccgg atcaaccgtt ggggttaatc aggcagattt tgaagtatat gatggtgaga 302761 tatttgtcat catgggtcta tcagggagcg gtaaatcaac tttagtacgg atgttaaacc 302821 ggcttattga accgactgcc ggaaatattt acattgatgg tgacatgata acaaatatgt 302881 caaaagacca gctccgggaa gtccgccgga aaaaaatcag catggtcttc caaaagttcg 302941 ctctgtttcc gcacagaacg atacttgaaa acacagaata cggactggag cttcaaggtg 303001 tagacaaaca agagcggcag caaaaagcgc ttgagtctct taagctcgtt ggactggaag 303061 gatttgaaca ccaatatccc gaccagcttt ccggcgggat gcagcagcgt gtcggccttg 303121 cccgcgcgtt gacgaatgac ccggacatcc ttctgatgga cgaagcgttc agtgcgctcg 303181 atccactgat tcgtaaagat atgcaggatg agcttcttga tcttcacgat aatgtcggaa 303241 aaacaattat ctttattacg catgacttgg acgaagcgtt gcggatcggc gacagaattg 303301 tcctaatgaa ggacggcaac atcgttcaaa tcggcacgcc tgaagaaatc ctgatgaatc 303361 catctaacga atatgttgag aaattcgtcg aagatgttga tttgtctaaa gtcctcacag 303421 caggccacat tatgaaacgc gctgaaacag tgcggattga taaagggcct cgcgtagcat 303481 tgacactgat gaaaaacctt ggaatttctt caatttatgc agtggataaa caaaagaaat 303541 tattaggtgt tatctatgcg tctgatgcga aaaaagcggc tgagtctgat ttgtcacttc 303601 aagacatctt gaatacagaa tttacgactg taccagagaa tacgtatctg actgagattt 303661 ttgacgttgt gtccgatgcg aatattccaa ttgcggttgt ggatgagaag caaagaatga 303721 aaggaattgt cgtaagaggc gcgctgattg gcgcacttgc cggcaataac gagtatatca 303781 atgctgaagg cactaacgaa caaacacaag atccttctgc acaggaggtg aaataagatg 303841 gatagactgc ctagaatacc tttagcagat attattgacc gttttgttga ctggattacg 303901 atgacgtttg gcggattctt cgacggaatc gctaacggat tggccgcttt tgtaaatgga 303961 attgtcaccg gtcttggatt tattccatct attttgttaa cgattatttt cgccgcactt 304021 gcgtggtgga tcagtacaag gggaattgcg ttatttacgt tgattggatt cctcctgatc 304081 gattatttag gatattggga cccaatgctg caaacattgg cgcttgtttt gacatctgtg 304141 attatttcga ttgtggtcgg ggttccgatc ggaatttggg cgtctcagaa agaaacggtt 304201 cgccgtattg taacgccaat tcttgattta atgcagacaa tgcctgcttt cgtatatcta 304261 ttgccggcga ttttcttctt taacatcggt gttgtgccgg gtgttgttgc atctgttatc 304321 ttcgcgatgc cgccgacaat ccgcatgact gttctcggta ttaaacaagt gccggcggat 304381 ttgattgaag cgactgaggc attcggttct acaacagctc agcgtttgtt taaagttcag 304441 ctcccgcttg cgacaaaaac gattttggcc gggatcaacc agagcatcat gcttgcgtta 304501 tcaatggttg ttatcgccgc aatggtcggt gcaccgggac ttggttctga agtatacagt 304561 gccgttacac agctgaaaac cggggtcgga gtagaggccg gtatcgccat cgttatcgtt 304621 gccattaccc tggaccgtat tactcaaaat attaaagtga agaagaaaag cagggggaat 304681 gcctgatgct taaaaaaatc ataggcatcg gcgtttccgc catgctggcg ctctcacttg 304741 cggcttgcgg ttcagaaaac gatgaaaatg catccgcagc agaacaagtg aataagacca 304801 tcatcgggat tgaccccggt tcagggatta tgtccctgac tgacaaagcg atgaaggatt 304861 atgacctgaa tgactggaca ttgatttcag cgtcaagtgc tgcgatgacc gctacgctta 304921 aaaagtcata cgaccgtaag aaaccgatta tcattacagg atggacaccg cactggatgt 304981 tctccagata taagctgaaa tatctcgatg atccgaaaca atcttatggc agcgcagagg 305041 aaatccatac gatcacacgc aaaggcttca gcaaagagca gccgaatgcc gcaaagcttc 305101 tgagccagtt taaatggacg caggacgaaa tgggcgaaat catgatcaag gtggaagaag 305161 gcgagaaacc tgccaaagtt gctgctgagt acgtcaataa acacaaggat cagattgccg 305221 aatggacaaa aggcgttcaa aaggtgaagg gagacaaaat caaccttgcc tatgtggcgt 305281 gggacagtga gattgcaagt acaaacgtca taggcaaagt cttagaagac ttgggctatg 305341 aggtaacact tactcaggta gaggctgggc cgatgtggac tgcaattgcg acgggaagtg 305401 cggatgcatc cctttccgca tggctgccga atacccataa agcatacgcc gctaaatata 305461 aaggcaaata tgatgatatt ggcaccagta tgactggtgt gaagatgggg cttgttgttc 305521 ctcaatatat gaaaaatgtc aactcaattg aagatttgaa gaagtaatca aaaaagcagc 305581 ctgtgtcagg ctgctttttt tgcgttaaga agcgttagcg gcagcaagtg attccgcctt 305641 ctgaaatgtt ttgagcacgg cgttcgccaa aatatgaatg ccggtaaaca tcgcatttct 305701 gtcaaaggtc atgtgcggat gatggagccc cggctggagc ccgcagccta gtccgagcat 305761 cgttgttttc agattcggca ccttcacggc gtaaaaatgg aaatcctcgc cgccggtggt 305821 gacaagcggg tcatcaagcc gctcagcccc gatgatttcc gtaatggctt ctgccatgat 305881 cgcttcagct tctttatttt gtgttgccgc aggaaggctg tgttctttgt gcagctcgat 305941 ctttgcgcca aatgcagcgg cggccgcttc acaggctctt tctgtttcgg cgattaatgc 306001 ctccatggct tcattggtct gtgcgcgcaa atcaaggctg aacgatgctt ttcctggaat 306061 gatgttagag ctttcaccgc cggcttgcag ttttgtcatt ttgacggtat gcgggatttg 306121 cgggtcaata tgaatgagtc cgagcttgtg tacaagaaat gccgcaattt caatgctgtt 306181 tttcccgagg tgcggacggg cgccatgagc ctcttccccg atgatcgttc cctcaatgtg 306241 ctggcttgat ccgtgcagaa tagaaggagc gcagcggccg ttctgtgttt cctggatcgg 306301 acggacgtga acgccataca aatagtcgat atcatcaagc acgccttctt ctatcatttt 306361 caaggcgccg ccgccttttt cttctgccgg ctgaaagata aaacggattg tgcccttcgg 306421 aagctcaggt tgttttttta gcagcattaa cgtgcccaat gccattgtca tatgtgaatc 306481 gtgtccgcag gaatggttgg cgcgaaatgt gccgttaacc tcctgccaca gcgcgtcaat 306541 atcagcgcgt accgctacaa caggtgagcc tgagccgatt tcgccgacaa ccccggtgca 306601 gtctgaaaac gtgcgcgtcc ggcaccctaa atcctcaagc ttttgtttca aaaatgaagt 306661 tgtctcatat tccttccagc tgacttcagg gttcgcgtgc agatgctcga agatgtccat 306721 aatggtttgt ttcatttctt ctgaaagctt ttgcatggta agaaatacct ccttctatca 306781 gaatgaattt ttaccttctt tactttattt atattgaaac aggaagatag gctgtatata 306841 atatagcaca tattgctact attcagaata attaatattt tcaaacagag gggatggatc 306901 gaaatatgag tatgccagca gccgaaacac agcctaagaa aaaacgtatg acatttaaaa 306961 tgcctgacgc ctatgtcctc ttatttatga ttgctttcat ttgcgcaatc gcttcatata 307021 ttgtgccggc aggtgaattt gaccgcgtga caaaggggga tgtcacgacc gctgttccgg 307081 gaagctatca ttcaattgaa cagtctccgg tcagattgat cagctttttt acttctctac 307141 aggatggaat ggttggatca gcacccatca tctttctgat tttattcaca ggcggcacca 307201 ttgctattct agaaaaaacg ggtgccatca atggcctgat ttacaatgtc atcagcaaat 307261 tccgcacaaa gcaattatta tttatttgta ttgtcggcgc attgttctcc attctcggaa 307321 caaccgggat tgtcgtgaat tcagttatcg gttttatccc catcggcctc attgtggcac 307381 gatccttaaa atgggacgca gtcgcgggag ccgctgttat atacatcggc tgctacgctg 307441 gatttaactc caccatatta tcaccgtcac cgctcggttt atcacaatca atcgcggagc 307501 tccctctttt ctcaggaatc ggcctgcgag ttgtgatata catatgcttt ttgctgtctt 307561 ctattattta tatctatttg tatacgagaa aattaaaaaa atcaaaagat gccagtgtgt 307621 taggaacaga ttggttccct gcggcaggaa tgggcgaagc cggtaaagaa gaagatcagt 307681 cagtgccgtt taccgttcgc cataagctga ttttggctgt ggcgggactc tcacttgtcg 307741 gatttttata cggcgctttg aagcttggct ggtcagattc ccaaatggct gcgacattta 307801 tttttatttc tgtccttgcc ggtttaatag gcgggcttgc ggcgaacgat attgccaaaa 307861 ccttcattac gggctgccaa agtcttgtat acggggcgct gattgtcggg atggcacgaa 307921 gcatttccgt tatccttgaa aatggaaagc ttctcgatac tgtcgtcaat gctttggctt 307981 cacttttgga tggattcagc ccgattgctg gggcaatcgg catgtatatc gccagtgcgc 308041 tgcttcattt tctcatctct tcaggttctg gcgaagccgt tgtatttatt ccaatcctgg 308101 cgccgctcgc tgatttgatg ggaatcacga gacaggttgc ggttgaagcg gttatgcttg 308161 gagaaggggt cgtcaactgt gtgaacccga catccggcgt tctcatggcg gtgcttgccg 308221 ccagcggtat tccgtatgtc aagtggctgc ggtttatggt gccgcttgct ctgatttggt 308281 tcttgatcgg gcttgtcttt atcgtgatcg gagtcatgat caattggggg ccgttttaac 308341 gattgctgcc cgccggcttg tacggcgggc ttttgagtta ttcattgcag aagcgcaggc 308401 tgttattgta acatgtaagc cataagccat tcgtaaaagt gcgggaggaa ggtcatgaat 308461 aatctgcgta atagactttc aggcgtgaat gggaaaaata agagagtaaa agaaaaagaa 308521 caaaaaatct ggtcggagat tgggatgata gcgggagcat ttgcgctgct tgatgtgatc 308581 atccgcggca ttatgtttga atttccgttt aaagaatggg ctgcaagcct tgtgtttttg 308641 ttcatcatta tcttatatta ctgcatcagg gctgcggcat ccggaatgct catgccgaga 308701 atagacacca aagaagaact gcaaaaacgg gtgaagcagc agcgaataga atcaattgcg 308761 gtcgcctttg cggtagtggt gcttacgatg tacgacaggg ggattcccca tacattcttc 308821 gcttggctga aaatgattct tctttttatc gtctgcggcg gcgttctgtt tctgcttcgg 308881 tatgtgattg tgaagctggc ttacagaaga gcggtaaaag aagaaataaa aaagaaatca 308941 tcttttttgt ttggaaagcg agggaagcgt tcacagtttc gggcagcttt ttttatagga 309001 acattgattt gtattcactc tgccaagttg ttttgataga gtgattgtga taattttaaa 309061 tgtaagcgtt aacaaaattc tccagtcttc acatcggttt gaaaggagga agcggaagaa 309121 tgaagtaaga gggatttttg actccgaagt aagtcttcaa aaaatcaaat aaggagtgtc 309181 aagaatgttt gcaaaacgat tcaaaacctc tttactgccg ttattcgctg gatttttatt 309241 gctgtttcat ttggttctgg caggaccggc ggctgcgagt gctgaaacgg cgaacaaatc 309301 gaatgagctt acagcaccgt cgatcaaaag cggaaccatt cttcatgcat ggaattggtc 309361 gttcaatacg ttaaaacaca atatgaagga tattcatgat gcaggatata cagccattca 309421 gacatctccg attaaccaag taaaggaagg gaatcaagga gataaaagca tgtcgaactg 309481 gtactggctg tatcagccga catcgtatca aattggcaac cgttacttag gtactgaaca 309541 agaatttaaa gaaatgtgtg cagccgctga agaatatggc ataaaggtca ttgttgacgc 309601 ggtcatcaat cataccacca gtgattatgc cgcgatttcc aatgaggtta agagtattcc 309661 aaactggaca catggaaaca cacaaattaa aaactggtct gatcgatggg atgtcacgca 309721 gaattcattg ctcgggctgt atgactggaa tacacaaaat acacaagtac agtcctatct 309781 gaaacggttc ttagacaggg cattgaatga cggggcagac ggttttcgat ttgatgccgc 309841 caaacatata gagcttccag atgatggcag ttacggcagt caattttggc cgaatatcac 309901 aaatacatct gcagagttcc aatacggaga aatcctgcag gatagtgcct ccagagatgc 309961 tgcatatgcg aattatatgg atgtgacagc gtctaactat gggcattcca taaggtccgc 310021 tttaaagaat cgtaatctgg gcgtgtcgaa tatctcccac tatgcatctg atgtgtctgc 310081 ggacaagcta gtgacatggg tagagtcgca tgatacgtat gccaatgatg atgaagagtc 310141 gacatggatg agcgatgatg atatccgttt aggctgggcg gtgatagctt ctcgttcagg 310201 cagtacgcct cttttctttt ccagacctga gggaggcgga aatggtgtga ggttcccggg 310261 gaaaagccaa ataggcgatc gcgggagtgc tttatttgaa gatcaggcta tcactgcggt 310321 caatagattt cacaatgtga tggctggaca gcctgaggaa ctctcgaacc cgaatggaaa 310381 caaccagata tttatgaatc agcgcggctc acatggcgtt gtgctggcaa atgcaggttc 310441 atcctctgtc tctatcaata cggcaacaaa attgcctgat ggcaggtatg acaataaagc 310501 tggagcgggt tcatttcaag tgaacgatgg taaactgaca ggcacgatca atgccaggtc 310561 tgtagctgtg ctttatcctg atgatattgc aaaagcgcct catgttttcc ttgagaatta 310621 caaaacaggt gtaacacatt ctttcaatga tcaactgacg attaccttgc gtgcagatgc 310681 gaatacaaca aaagccgttt atcaaatcaa taatggacca gagacggcgt ttaaggatgg 310741 agatcaattc acaatcggaa aaggagatcc atttggcaaa acatacacca tcatgttaaa 310801 aggaacgaac agtgatggtg taacgaggac cgagaaatac agttttgtta aaagagatcc 310861 agcgtcggcc aaaaccatcg gctatcaaaa tccgaatcat tggagccagg taaatgctta 310921 tatctataaa catgatggga gccgagtaat tgaattgacc ggatcttggc ctggaaaacc 310981 aatgactaaa aatgcagacg gaatttacac gctgacgctg cctgcggaca cggatacaac 311041 caacgcaaaa gtgattttta ataatggcag cgcccaagtg cccggtcaga atcagcctgg 311101 ctttgattac gtgctaaatg gtttatataa tgactcgggc ttaagcggtt ctcttcccca 311161 ttgagggcaa ggctagacgg gacttaccga aagaaaccat caatgatggt ttcttttttg 311221 ttcataaatc agacaaaact tttctcttgc aaaagtttgt gaagtgttgc acaatataaa 311281 tgtgaaatac ttcacaaaca aaaagacatc aaagagaaac ataccctgga aggatgatta 311341 atgatgaaca aacatgtaaa taaagtagct ttaatcggag cgggttttgt tggaagcagt 311401 tatgcatttg cgttaattaa ccaaggaatc acagatgagc ttgtggtcat tgatgtaaat 311461 aaagaaaaag caatgggcga tgtgatggat ttaaaccacg gaaaggcgtt tgcgccacaa 311521 ccggtcaaaa catcttacgg aacatatgaa gactgcaagg atgctgatat tgtctgcatt 311581 tgcgccggag caaaccaaaa acctggtgag acacgccttg aattagtaga aaagaacttg 311641 aagattttca aaggcatcgt tagtgaagtc atggcgagcg gatttgacgg cattttctta 311701 gtcgcgacaa atccggttga tatcctgact tacgcaacat ggaaattcag cggcctgcca 311761 aaagagcggg tgattggaag cggcacaaca cttgattctg cgagattccg tttcatgctg 311821 agcgaatact ttggcgcagc gcctcaaaac gtacacgcgc atattatcgg agagcacggc 311881 gacacagagc ttcctgtttg gagccacgcg aatgtcggcg gtgtgccggt cagtgaactc 311941 gttgagaaaa acgatgcgta caaacaagag gagctggacc aaattgtaga tgatgtgaaa 312001 aacgcagctt accatatcat tgagaaaaaa ggcgcgactt attatggggt tgcgatgagt 312061 cttgctcgca ttacaaaagc cattcttcat aatgaaaaca gcatattaac tgtcagcaca 312121 tatttggacg ggcaatacgg tgcagatgac gtgtacatcg gtgtgccggc tgtcgtgaat 312181 cgcggaggga tcgcaggtat cactgagctg aacttaaatg agaaagaaaa agaacagttc 312241 cttcacagcg ccggcgtcct taaaaacatt ttaaaacctc attttgcaga acaaaaagtc 312301 aactaaccgc aactttagag taaagggctg attgtcaatg tgggagcagt tgtatgatcc 312361 gtttggaaac gagtatgtga gcgcacttgt ggcgctcact ccgattctct tttttctttt 312421 ggctttaact gttttgaaaa tgaaaggcat tcttgcggca tttcttaccc tagccgtcag 312481 tttcttcgtc tccgtttggg catttcatat gccggttgaa aaagcgattt cttctgtttt 312541 gttaggaatc gggagcgggc tgtggcccat tggctacatc gtcctgatgg cggtgtggct 312601 gtataaaatc gccgtgaaaa ccgggaaatt taccattatt cggtccagca ttgccggcat 312661 ttcgcctgac caacgattac agctattatt aattggtttt tgttttaacg cgtttttaga 312721 aggcgcggcc ggttttggtg ttccgattgc gattagtgcg gcgctgctcg tcgaacttgg 312781 ttttaaaccg ttaaaagcgg cggcgctctg cttgattgca aacgctgcct ccggagcctt 312841 tggggcgatt gggattcctg tcatcacagg ggcgcagatt ggtgatttgt ctgctcttga 312901 gctgtctcgg acattaatgt ggacactgcc gatgatctca tttttaatac cattcctgct 312961 tgtattctta ttagaccgaa tgaaaggaat caaacagaca tggcccgctc ttctggttgt 313021 gagcggtggg tatacagcgg ttcagacact gacaatggcg gtgctcgggc cggaattagc 313081 aaacattttg gcggccttat tcagcatggg cgggcttgcc ctcttcctcc gcaaatggca 313141 gccgaaagag atttaccgcg aggaaggggc cggcgatgct ggtgagaaaa aggcataccg 313201 tgccgctgac attgcgaaag cgtggtctcc tttctacatt ttaactgcgg cgatcaccat 313261 ctggagcctt cctgccttca aagcgctttt ccaagaaggc gggctgttat atcaatcaac 313321 gctcctgttc aaaatgcctt ttctgcatca gcaaattatg aaaatgccgc cgattgcgcc 313381 atctgccatg ccgttagatg cagtctttaa agttgatctg ctgtcagcga ctggtacagc 313441 gattttagcg gcggtcatcg tgacagggct gttcagcaaa aagttctcct ctcgggatgc 313501 ctttgcttcc ttgaaggaga cgggaaaaga gctgtgggtg ccgattatga cgatctgctt 313561 cgtgatgggg tttgccaatc tggccaactt cgcagggctc agctcttcaa ttgggttagc 313621 attggcgaaa acaggagacc tgttcccgtt tgtcagtcct gttctcggct ggattggcgt 313681 gttcatcacc ggttctgttg tcagcaataa tgctttgttc ggccatttgc aggttgtcac 313741 gggagcgcag atcggtgcgg gttcagattt gctgttagcc gcaaatacgg cgggcggtgt 313801 catggcgaaa cttgtttctc ctcaatctat cgccatcgct gccgcagcgg tcggccaaac 313861 aggcaaggaa tctaaactgt ttaaaaggac agtggcgtac agcctgattc tgttattgat 313921 catttgtata tggacgttta ttcttgcaag attaggagtg taatagaaaa aagcagtaca 313981 tgcccagcat gtactgcttt ttttatgtta atttgctttc tttgtcattt cggctgttgt 314041 tttcactctg gcttttccca taaataaaat ggtaaccgcc gcgaggacaa ttggaatcaa 314101 agcgagcaaa aagacatacg tgatacttga tgacatcgcg tcaataatgc gattcaggat 314161 cgcatcagga atctgggaac gtgttcccgc ttggaatatc tcctgcgggt cgccaatatt 314221 ttgcgcagcg cctgatcccg ctgagccttt cataccgctg aaggcgtcat tcagcttgtt 314281 tgtgaatacg tttgtttgca ccgttccgaa aatggtgaca cctaaggtca tgccaaatga 314341 tcgcaaaaat gaatttgtag agtttgccgt tccccgaaag cgaggttcaa gatcattcat 314401 cgatgccgcc ggcagcaggg agaagttaaa gcctacacca aagcctgaaa tcatcataaa 314461 gactgtcagc catacccgtg ctgtgtcagg cgtcatattg gaaagaagca gcatgccgat 314521 aaagaaagct ataacagata tcagcatcaa attgcggaag cttgccttcg tttggaagat 314581 cccgccgatc atgcttccga tgactgatcc aatcatcatc ggcgtcagaa tgaagcccgc 314641 gcttgtcgcc gagctgccgt agaccgcctg aacgaaaatc ggaataaata ccgctaaaat 314701 aataaatgtt ccgccataca ggaaagcgag aatctgtgct gtggcaaaca agcggttctt 314761 aaacatccag aaagaaataa tcggctcttc tgcttttctc tccacaataa aaaaggcaat 314821 gaagaaaacg gcgaatacaa taaacagccc gatgatctga atggagttcc aatcgtatgt 314881 tttgccgcca agctcaaggg cgaacatcag gcatacaatg gatacgacta aggtaatcgc 314941 gccgccccag tctattttct gctttctgtg ctccagagat tctttgtagt agcgaataat 315001 gaaaaacaat gacaatgcgc cgatcggcac attgatgtaa aacacccagt gccagctgat 315061 cgaatctgta atgatcgcgc ctaagagcgg accaagaaca ctggataatc caaatacagc 315121 accgaacatg ccggacattt ttccgcgttt ttccggcgga aacaaatcaa agataatggt 315181 aaaggcaatc ggcaggagcg cgccgcctcc gatcccttga atggcccgga agatgatcag 315241 ctgattcatc gtctgggcaa tcccgcataa agcagaaccg attaagaaaa aaataagtcc 315301 aaacaggaaa aaacgttttc ggccgtacat atcggaaagc ttgccgtaaa tcggcatgcc 315361 agccataacc gccaccatat aggatgccgt cacccaggca aatttatcga agcttccaag 315421 atcggctacg atattgccca tcgcggtggc aacaatcgta ttgtccattg cagacatcaa 315481 gatgcccagc aggagaccga ggaccacaaa tttggtggaa gcctgttttg ctgttgttgt 315541 gtccatttgt tctacctcct cttacttttc tatgtaagtt ctgatatcat gataatagtt 315601 tgattgttga atatctcgat tatcaagata aactcgattt tatagggagg actgtcagtt 315661 gtcaacaaga aattccagaa gtgagttgga aaagactgct gttcagcttt ttcgaaaact 315721 gggcacaaga acggttctgt ttcatcaggc agccgctcaa gctctcggtc tgtttcccac 315781 cgatttgaaa tcagctgaca ttttaaatga agcagggccg atgacggccg gagagctggg 315841 gaaaaaaacc ggcctcagca cgggttccgt cacggcgctt gttgaccggc tggaaaaagc 315901 ggggtatgtg gctcgtgaaa aggacccgaa cgatcgcagg agagtcgtaa tcgtcccttt 315961 gactgcttcg aaaaaacata taaaggattt gttccgtcct ctgtctgagt caacgatgga 316021 tttgtgccgc gaatatacgg aagaggagct ggaactcatt ttcagttttg taggcaaagc 316081 tgccgatatt atggaggaag agcttgaacg tctgaaacag taagtgaatt tgtgcatagc 316141 ttggcccgtt cccgaataaa ttgtacaagt tacataagag aagggagtac gggccggtga 316201 acattttttt gagctatatt gtgctgggac tgtccttgtc tgcgcctgtg gggccagtga 316261 atgcggcgca aatagacaaa ggaattaaaa acggtttttg gcatgcatgg attttcggtt 316321 taggcgccat gacagcggat gggctgtaca tgctttttat ctatttcggg ctgtcgcagt 316381 tcttgaccgc tccatttgtg aaaacgtttt tgtggctgtt cggctttttt gtcctgacct 316441 ataccggaat tgaaacgctg aaaaacgtca gagaaccgat ggatgtgcga agctcgcggg 316501 ggaaaccgtc atacaggaaa acattcgcat cgggttttct catttcattg tcaaacccat 316561 tgagcatcct tttttggctt ggaatttacg gaagcattct tgcgaaaaca gcagaggcct 316621 acaatatgaa tcagcttcta atctatagct ccggcatcat gatcggcatt ttaatctggg 316681 atttctgcat ggctatcaca gccagtacgt tcagaaacct gcttcatgaa aagctattga 316741 gaggattgac cggaatcgcc ggtgtatccc tccttgtgtt tggcttttac tttggttatc 316801 agggcatcaa acagttattg ggctgattca tgaaggacag tcacctgccg cttccagttt 316861 taatatagta tccagatgat actggaggtg gatcaatggt gaatgggatt tacaccaaaa 316921 gttttctgga acgtattcag gaagagcttc ctgaatggca aagaatcgct tttgagctgc 316981 tggcagaaac tctgggggac gacgcggata catttccgtg cattcccgga cgccaggcgt 317041 ttctgactga tcagcttcgg attgcttttg ccggagatcc gcgggaaaac cgcacagcgg 317101 aggaactggc tccgttgctt gcggagtacg gcaagatatc gcgggacacg ggaaaatacg 317161 catccctcgt tgtgttgttt gatacaccgg aagatttggc ggagcattat tcgattgaag 317221 cgtatgaaga gctgttttgg cgctttttaa atagactgag tcatcaagac gaaaaagaat 317281 ggccggaaga cattccggcc gatcctgagc attataaatg ggagttttgt tttgacggcg 317341 agccgtattt cattctgtgc gctacaccgg ggcacgaggc aagaagaagc cggagctttc 317401 ctttttttat ggtcacgttt cagccaaggt gggtgtttga tgacctaaat ggatcaactg 317461 catttggccg taacatgagc aggctgatcc gatctcgttt agaggcctat gatcaggctc 317521 cgattcaccc gcaattaggc tggtacggag gaaaagataa tcgtgaatgg aagcagtatt 317581 tcctccgtga tgacgaaaaa caggtatcga agtgcccgtt ttcttattta aagaacatgt 317641 tcaacaaaat gaaataaatc aaggactggc agggcgatct ttatgaccct gctttttttg 317701 atagatcatg gtaacgatgg cgataatcac gagaaaacct atgctgacga aaaaaccggg 317761 ccggcttgat ttttcaaaca atgtaccgga cacagctgca gcaatcagaa ccatcgctaa 317821 ataaatttgc gtttttccca tgccctcggg atcagtcagc tttttgctgg agaacaggat 317881 aaacagccaa gtgtataaaa gcataagccc cgcagctgtt gtcatatgct cataaatgtt 317941 tttaggcagc actaacgaca aaataatgga gaggacaagc cccgcaaacg tcagcccaag 318001 tgccggccag catatttttt tgccttcctt tagagtaaag catttcggcg cgtcgccgtc 318061 atcagccatt gtacaaagca atgtcgtaac cgcaaatagc gaagcgacaa gggtcgagaa 318121 ccctgcgatg atgaaaatcc cgttaaatat atcaaggatg atctcaaggt tatatccttt 318181 taatgacgta atgaacggac tgtcctgttc agtaaacgtg tgtaacggaa ccaaaagcag 318241 agcaagcccg attgaaatga tataaataat cgccagcgtc gccagcatca gtttccctga 318301 tttagacgct tcctcaggtt tttttaagtg aaccgccatc agccccatga cctcaattcc 318361 gccaaaagcg taaaacgcgt agattaaacc tgtccacagc cccatggcgc cgtatgggaa 318421 aaactcactc gtcttatttg gaacatgtat gccatgattt ccgccggaca ggataccgca 318481 taaagccagg atggcaatga caataaacat aaaaatagca gctgttttaa tgactgccag 318541 cacgttttct gttttttcaa agacggacag gccggtgaaa ataataagga gcccaagtac 318601 tgcgtagatt gaggcaaaca cccatagcgg cacttgagga aaccaatgct tcgtaaagag 318661 cgaaatggct gtcagctggc ttccggtaat cagcatttct gatgtccagt acacccagcc 318721 gttgctgaag cctgcccatt tgccgaatgc ttttcgggca tacgcacaaa acgagccctt 318781 ttccggctgc ttcgccgata gcttggcgag ctgttcaaag acaaaatacg taccgatccc 318841 tgcgatcaga aatgaaagga gaacggaaaa accgcttttt acaattgcga tgctggaacc 318901 gagaaagaag cctgttccaa tcgtgcagcc gactccgatc agtgacagct gccaccaagc 318961 cagattccct tttggctggt ctttttttgt ttggctcatt atttattcaa ccccttttat 319021 ctaaggttag attgtgatct gtccaaagct tatatacatc ggatttttgc ctctttttac 319081 atggagaagg aagcagacgc tcatactaat gaaaaaagga gcaaaccaat gacacagcaa 319141 tatattgtgg agccgaaaaa agggcttggg ctgaagctga aaaaggggca gattttaaag 319201 gtggttgatg tagaagggca gcaggtggct gattttgtcg cataccatgc caaggatttt 319261 tatgaacacc ttgatcaggg agcgacgata gacgccaatc actccattca tgtgaaggtc 319321 aacgaccatc tctactccaa cctgtataag ccgatgttaa ccctgattga agatacggtc 319381 ggcaagcatg atctgctgtt gcccgcctgc cgtcctgata tgaacaggct cttatatggg 319441 aagcaaaagg atgagtttca ggatacgtgc tatgacaata tgaaccgtgc gcttgagcag 319501 tttggcgtac cgaagcccca catgcattac ccatttgcga tttttatgaa tactgtcctt 319561 gatgagaaag ggaatctgtc tgtggaaacg ccgctttcga atgccggaga ttatgtaagg 319621 ctcagggcgg agatggattt aattgtcgcg ttttcttcct gcccgattga aaaagggaaa 319681 tgcaatggcg acagtgtgac atccatacgg gttgaagtca gctgatctct cttgttcaca 319741 gtgaatgaag acctgtgcta tatttaatag ggatacataa cagtcatgat tcattttcat 319801 tgatttaggg aaatgatcag taataaggga aaatgtacag gaggaatgat tgggatgagc 319861 atgcaggaaa agattatgcg tgagttacat gtgaagccct caattgatcc aaagcaagaa 319921 attgaggacc gagtcaattt tttaaaacaa tatgtaaaga aaaccggtgc taaaggcttt 319981 gtattgggaa tcagcggggg ccaggattca acacttgcgg gaagactcgc tcagcttgcg 320041 gtggagagca ttcgcgagga gggcggagac gctcaattta tcgcggtccg tcttccgcat 320101 ggcacacagc aggatgaaga cgatgcccag cttgctttga agtttattaa gccggataaa 320161 tcatggaagt ttgatattaa atcgacagtc agcgcttttt ctgatcagta tcagcaggaa 320221 acaggcgatc agctgacgga ctttaataaa ggaaacgtaa aagcaagaac aagaatgatc 320281 gcgcaatacg cgatcggcgg ccaggaaggt cttcttgtgt taggaacaga ccatgctgct 320341 gaagcagtga ctggtttctt tacgaagtac ggtgacggcg gagcagacct cctgccgctg 320401 acaggcttga cgaagcgcca gggaagaacc ttgctgaaag agctgggtgc accggaacgc 320461 ttatacttaa aagaaccgac tgccgatctg ctcgacgaaa aaccgcagca gtcggatgaa 320521 acagagcttg gcatttccta cgacgagatt gacgattatc tcgaaggaaa agaagtatca 320581 gcgaaagtat cagaagcgct ggaaaaacgc tacagcatga ctgaacataa acgccaggtt 320641 ccggcgtcta tgtttgatga ctggtggaaa taagttgaag aaagcccgct ctcggagcgg 320701 gcttttgtcg tgtacagaag ctttatttga tgcggatatg attcagcttt accattaatc 320761 tgtcggcgaa ccttcggagg ctgcctcttg tatcaggatc taatgggagt tcggctctcg 320821 cggcaatgtt ctctgccaca tcctgaatcg acaggttgtc tgtttgaatg tggtcctcaa 320881 aaatgggtga tgataatcct tcaacacagc ggtcaatttg tttggcggcc catgagtttt 320941 ttccttctgc tctggtgcgc agccttttta acaaggtttc ctttgaagcc attagtgtaa 321001 agtggtgaac gatcctgcct tcctgtctga gcctgccgat gatctcattg aagtattcag 321061 ggtgtacaat cgtcataggc acaataagga tgccgcggta tgtatctgtc agagaagcta 321121 gcaaactgta attgaacgcc cgccataaag gatagctttg aaaatcgtcc tttgcgatct 321181 cctgcggcac catggagcgc agcgcaaaac ccattttctc gggatcatac acgtaagatg 321241 ggttcagcct tctgtgcagt tcgaaggctg tttgtgtttt tcccgaaccg aatgccccgt 321301 ttatccaaat gatcatcgcc atttctccct tcctatttat catacagaaa aagacccttc 321361 catcgaagag tcagctggaa aaacaataaa ggcggaaggt tttaacgctt ttttgcgtcg 321421 aagtattaaa atacctgcag aaatgttgta caatgaatgt cattcaggca aaaatggcta 321481 caacaaagcg cactataagc ttgaccggta aagccggtat ctatataaat attcgctaaa 321541 taagcatata atgaatatat aatttcattc cttaggagga tttcgccgaa gatgaacgct 321601 aaacgagcca tcccagtaag agaaagaaat atcgtcctga tcggattcat gggtgtagga 321661 aaaacaacaa tcggccaatt ggtcgctaaa aaattatata gagattttat tgatattgac 321721 cagcagatcg aaaaggattt caatatgtca attcctgaga tatttgagaa aaagggagaa 321781 gactttttcc ggaaaacgga gaaggaatat attttagaca tctgccatca taaacgattc 321841 aaaatcgtat ctctgggcgg gggatctttt aaacaagaag aaatcagaaa ttgctgtctg 321901 gaaaactgtc tcgtgcttca tctggacctg tcatgggaga actggaagca gcgcgcggat 321961 ttattgatcg aaagccgccc tgtactgcat aaccgttcaa tggatgaaat ggaacagctg 322021 tttaacgaaa gaaaagtcat ttatgacaag cacaattcaa aagtggcaac agacaacctt 322081 tccccggaag aggttgccga ttacattgtt gagacattaa aaattggctg ggatctttat 322141 cagccgatgt aaaaagccgt gcgcagcgca cggctttttt tatcgtttta tcccttgtat 322201 caaaatcgct tttaaacaaa aggagatggg ctgtccgttt tggttcaatg taatacagaa 322261 cgtgtcgcgt gcttcgtctg atgcgtgatt caagtgggta atgatttgtt tttctcggtc 322321 agcgggggtt ccgcctcgtt tgatccagct atcgtattga atcggcaagt tccacttttg 322381 gatgtcttga taggccagtt gattggcgct gaacatcgcc tgccattctg ataatgagct 322441 ttcacgaaca tgggaagggt ctcgaagccg gttcaaatga ttgacaaact catcaagaac 322501 gggatcttca ggcgcgtaat gatcaactaa gagaaaacgt ccgtcctgtt ttagtacgcg 322561 tgcaacctct ctgacagctt tgcggacatc tgaaaaatgg tgggctgcgt atcggcaggt 322621 gatgatgtca aatgaatcgt cggggaaggg gagtgactct gccgttcctt gctgaaagcg 322681 tacgttttca actccttttt cttgcgcgaa ggaggacgca acctcaacca tctctttcgt 322741 tgcatcaaca ccgatgcact cctgtacata aggagaaaat gccagcgccg tatggccggc 322801 gcccgctcct atatccagca ctcgatgctc tgcccggcat tccgctgttt tgatcatcaa 322861 ccccaaatct tccccctcgg caaatacctt ttcatcccga tacatctcgg cgtttttaga 322921 aaacggtgtt tcatttgtca tttgaaccag ctccttcttt tcgtaaatga tgatatggat 322981 tatgttagca atttctgtta tgattcgtcc aagatataaa aatgatgaaa atgataggtt 323041 caacctatgg aggctgaaat ggatattaaa gtgatggaat atgcagcgga aattgcccgg 323101 cgccaaagct ttacaaaggc ggcggaacat cttcatatcg cacagccgtc tctcagccag 323161 caaatcaaaa agcttgaggc tgagctgggg cttacccttt ttcacagatc ccatggctct 323221 gttacactga cacctcacgg caggcgtttc attgaaaaag ccgaggacat cattcgttcc 323281 agagatgatt tgcttcggga aatgcaggag cgatcacagg gaatcggtca taaattatcc 323341 atcgggattc ctgctgtaac agggagatat ctctttcctc cgctgctgaa gcagtttttg 323401 gcgcgctatc ctcatgtgga ggttcagctt gttgaaaaag atccggtttc attagagaag 323461 atgacggcaa agggagaagt tgacctttct gttttatcct tgcccatcga ggatgaacgg 323521 ctctccatta cacccttgct cacggaaccg gttgttctcg cggtgccgaa ggaaaaacaa 323581 aggtggatgc cgccggaatt ggtcgcgctg attgagaaag cgctggaaga agatgaggga 323641 cgccagccgt gtgtgccgat tgacatggta aggaacgtgc cctttattct gttaaaagaa 323701 ggcttcggct ttcgcaggac agttctcgat ctctgtgcgg aaagcggctt taagccgaat 323761 gctgccttta agacgagcca tattgaaacc gcccaatctc ttgtggctaa cggattaggt 323821 gtgacaatgg caccgaatat ggtcagaagg gataaagatc cgggtgtgat ctatttatcg 323881 attcaatccg cgccatcacg aaccctcgtc tttgtctttt taaagaaccg ctatgtcagt 323941 ctgacggccc aggcctttat ggaactaagc cgggaaagtc ttaaacaaac gtttgatgaa 324001 ggctgtctgg gaaacaaaga tgaaaatatt tagaaaacaa agacgaaacg tggtagtata 324061 ggaatacaaa ctaaatctta taaaacaaag gggaataatc ggaaatgcaa ctattcgatc 324121 tgccgctcga ccaattgcaa acatataagc ctgaaaaaac agcaccgaaa gatttttctg 324181 agttttggaa attgtctttg gaggaacttg caaaagtcca agcagaacct gatttacagc 324241 cggttgacta tcctgctgac ggagtaaaag tgtaccgtct cacatataaa agcttcggaa 324301 acgcccgcat taccggatgg tacgcggtgc ctgacaagga aggcccgcat ccggcgatcg 324361 tgaaatatca tggctacaat gcaagctatg atggtgagat tcatgaaatg gtaaactggg 324421 cactccatgg ctacgccaca ttcggcatgc ttgtccgcgg ccagcagagc agcgaggata 324481 cgagtatttc accgcacggt cacgctttgg gctggatgac gaaaggaatt cttgataaag 324541 atacatacta ttaccgcggt gtttatttgg acgccgtccg cgcgcttgag gtcatcagca 324601 gcttcgacga ggttgacgaa acaaggatcg gtgtgacagg aggaagccaa ggcggaggtt 324661 taaccattgc cgcagcagcg ctgtcagaca ttccaaaagc cgcggttgcc gattatcctt 324721 atttaagcaa cttcgaacgg gccattgatg tggcgcttga acagccgtac cttgaaatca 324781 attccttctt cagaagaaat ggcagcccgg aaacagaagt gcaggcgatg aagacacttt 324841 catatttcga tattatgaat ctcgctgacc gagtgaaggt gcctgtcctg atgtcaatcg 324901 gcctgattga caaggtcacg ccgccgtcca ccgtgtttgc cgcctacaat catttggaaa 324961 caaagaaaga gctgaaggtg taccgctact tcggacatga gtatatccct gcttttcaaa 325021 ctgaaaaact tgctttcttt aagcagcatc ttaaaggctg ataaatgtga aaagccgccg 325081 catatcatca ggcggttttt ttctgcaaac tgccggaatg agaacagact ggagacgaat 325141 agatatgaaa caaagaatca ttgatgaatt aaaacggatc gagcagtcat acggagtcaa 325201 aatcgtgtat gccgtcgagt caggaagccg cgcatgggga tttccctcgc aggatagtga 325261 ttacgacgtc cgctttattt atgttccgaa aaaggagtgg tacttttcaa ttgagcagga 325321 gcgtgatgtc attgaggaac cgattcacga tttgctggat atcagcggct gggagctgag 325381 aaaaacgctt cggcttttca aaaagtcaaa ccctccgcta ctcgaatggc tgtcctcaga 325441 cattgtgtat tatgaagcat ttacgaccgc agagcagtta agaaaactcc gcacggaggc 325501 atttaagcct gaagcaagcg tgtatcacta tatcaatatg gcgagaagga acgtcaagga 325561 ttatctacaa ggacaagagg tcaaaattaa aaagtacttc tacgttcttc ggcctatttt 325621 ggcctgccaa tggattgaaa agcacggaac cataccgcca atggacttta ctgttttgat 325681 gaatgaactt gttgctgaac ccgagctgaa ggctgaaatg gaaaccttgc ttgaacggaa 325741 aagaagaggg gaagagcttg acctcgaagc aagaatcgat gttattcacc aattcattga 325801 aacggaaatc gaaagaatca tggaagcggc aaaagaactg aaggcagaga aaaaagatat 325861 gacatctgaa ttgaaccgtt tgcttttgaa tacggttgaa gaagtgtgga aggatggagg 325921 aagctgatgt tttttgtcgc ttccttttct cctttattcg acagaatccc cccccgactt 325981 tctaactatc tgattgtggc aaacccacaa aaataatcag aatctttgta ttttgagaat 326041 attgtgaacg ctggttttgt ccatttacaa taaactcata caaatacttc ttagattgcg 326101 gggtgttgag gttggaagtg atcacaagag attttttctt atttttatcc aaaagcggct 326161 ttctcaataa aatggcgagg aactggggaa gtcgggtagc agcgggtaaa attatcggcg 326221 ggaatgactt taacagttca atcccgacca ttcgacagct taacagccaa ggcttgtcag 326281 ttactgtcga tcatttaggc gagtttgtga acagcgccga ggtcgcacgg gagcgtacgg 326341 aagagtgcat tcaaaccatt gcgaccatcg cggatcagga gctgaactca cacgtttctt 326401 taaaaatgac gtctttaggt ttggatatag atatggattt ggtgtatgaa aatatgacaa 326461 aaatccttca gacggccgag aaacataaaa tcatggtcac cattgacatg gaggacgaag 326521 tcagatgcca gaaaacgctt gatattttca aagatttcag aaagaaatac gagcatgtga 326581 gcacagtgct gcaagcctat ctgtaccgga cggaaaaaga cattgacgat ttggattctt 326641 taaacccgtt ccttcgcctt gtaaaaggag cttataaaga atcagaaaaa gtagctttcc 326701 cggagaaaag cgatgtcgat gaaaattaca aaaaaatcat ccgaaagcag ctcttaaacg 326761 gtcactatac agcgattgcc acacatgacg acaaaatgat cgactttaca aagcagcttg 326821 ccaaggaaca tggcattgcc aatgacaagt ttgaatttca gatgctgtac ggcatgcggt 326881 cgcaaaccca gctcagcctc gtaaaagaag gttataacat gagagtctac ctgccatacg 326941 gcgaggattg gtacggctac tttatgagac gccttgcaga acgtccgtca aacattgcat 327001 ttgctttcaa aggaatgaca aagaagtaaa aaaggagaga ttatcatgac aacaccttac 327061 aaacacgagc cattcacaaa tttccaagat caaaacaacg tggaagcgtt taaaaaagcg 327121 cttgcgacag taagcgaata tttaggaaaa gactatccgc ttgtcattaa cggcgagaga 327181 gtggaaacgg aagcgaaaat cgtttcaatc aacccagctg ataaagaaga agtcgtcggc 327241 cgagtgtcaa aagcgtctca agagcacgct gagcaagcga ttcaagcggc tgcaaaagca 327301 tttgaagagt ggagatacac gtctcctgaa gagagagcgg ctgtcctgtt ccgcgctgct 327361 gccaaagtcc gcagaagaaa acatgaattc tcagctttgc ttgtgaaaga agcaggaaag 327421 ccttggaacg aggcggatgc cgatacggct gaagcgattg acttcatgga gtattatgca 327481 cgccaaatga tcgaactggc aaaaggcaaa ccggtcaaca gccgtgaagg cgagaaaaac 327541 caatatgtat acacgccgac tggagtgaca gtcgttatcc cgccttggaa cttcttgttt 327601 gcgatcatgg caggcacaac agtggcgccg atcgttactg gaaacacagt ggttctgaaa 327661 cctgcgagtg ctacacctgt tattgcagca aaatttgttg aggtgcttga agagtccgga 327721 ttgccaaaag gcgtagtcaa ctttgttccg ggaagcggag cggaagtagg cgactatctt 327781 gttgaccatc cgaaaacaag ccttatcaca tttacgggat caagagaagt tggtacgaga 327841 attttcgaac gcgcggcgaa ggttcagccg ggccagcagc atttaaagcg tgtcatcgct 327901 gaaatgggcg gtaaagatac ggttgttgtt gatgaggatg cggacattga attagcggct 327961 caatcgatct ttacttcagc attcggcttt gcgggacaaa aatgctctgc aggttcacgt 328021 gcagtagttc atgaaaaagt gtatgatcaa gtattagagc gtgtcattga aattacggaa 328081 tcaaaagtaa cagctaaacc tgacagtgca gatgtttata tgggacctgt cattgaccaa 328141 ggttcttatg ataaaattat gagctatatt gagatcggaa aacaggaagg gcgtttagta 328201 agcggcggta ctggtgatga ttcgaaagga tacttcatca aaccgacgat cttcgctgac 328261 cttgatccga aagcaagact catgcaggaa gaaattttcg gacctgtcgt tgcattttgt 328321 aaagtgtcag actttgatga agctttagaa gtggcaaaca atactgaata tggtttgaca 328381 ggcgcggtta tcacaaacaa ccgcaagcac atcgagcgtg cgaaacagga attccatgtc 328441 ggaaacctat acttcaaccg caactgtaca ggtgctatcg tcggctacca tccgtttggc 328501 ggcttcaaaa tgtcgggaac ggattcaaaa gcaggcgggc cggattactt ggctctgcat 328561 atgcaagcaa aaacaatcag tgaaatgttc taagcgggac taaatgggca tcctccctgc 328621 gggggtgtcc atttcatcca tatactataa aaaagaggag gaagtgccat agaaaacaca 328681 cagctgatta tttcgatttg tatttatatg gcgggaatgc tgctaatcgg ctactttgct 328741 tacaagcgta cgtcgaatct gacggattat atgctgggag gacgctcttt gggtccggca 328801 gtaaccgctc tcagtgccgg cgctgccgat atgagcggct ggctgctaat ggggcttccg 328861 ggcgccatgt tttctactgg tctgagcggc gcttggatcg tcatcggact ttgccttgga 328921 gcgtgggcga actggcttta cgtcgcacca cggctgagaa cctatactga aaaagcgggg 328981 aattctatta caattcccgg attcctggaa aatcgcttcg gagatcaaac aaagcttctc 329041 agactgtttt cgggaattgt cattttagtc tttttcacgt tttatgtatc gtccggaatg 329101 gtgtccggcg gcgtcttatt caacagcatc ttggggatgg attatcacac cggcctgtgg 329161 attgtgacgg gtgttgttgt ggcatatacc ctgtttggcg gctttttggc agtcagctgg 329221 acagattttg ttcaggggat tattatgttt gccgcactca ttcttgtgcc gatcgttacg 329281 tttttccaca cgggaggagc aggtgataca gttgctgaaa tccgctctgt agatcctgat 329341 atgtttaata ttttcaaagg aacgagcgtc cttggcatta tttctttgtt tgcctggggg 329401 ctgggatact ttggccagcc gcatattatt gtgcgtttta tggcgataac gtctgtcaaa 329461 gagatcaaaa gagcgcgcag aattgggatg ggctggatga ttttgtctgc agtaggcgca 329521 gtgctgaccg gtttgggcgg aatcgcttat taccatcagc gcggcatgac actgaaggac 329581 ccagagacga tttttattca attagggaat atcttgttcc atccgattat cacgggtttt 329641 ctgatttcag cgattttggc cgcgattatg agtacaattt cttcccagct gcttgtgaca 329701 tcaagctctc tggtagaaga tttgtataag tcgatgttca gacgctcagc ttcagataaa 329761 gaactggtgt ttttaggccg actggctgtt ctggctgttt caattgtcgc gttggttctg 329821 gcttgggaga aaaataacac catccttgga ttggtcagct acgcgtgggc gggcttcggt 329881 gcatcattcg ggccagttgt actgctcagt ctgttttgga aacgaatgac caaatggggg 329941 gcactcgccg gcatgattgt gggagcagcg actgtaatca tttgggcgaa tgccggtctt 330001 tcggactttc tgtatgaaat gatacctggt tttgctgcga gtctattatc tgtctttttt 330061 gtcagcatat tgacgcaggc tccgtcacaa gctgtcacag accagttcaa cgactaccaa 330121 gatacaatgt cgcaataaag atcgaaagga ggaggaaggg gctgtccctt tttcctcttt 330181 tctcctttta agcggccatt tttttctttt ggaaacaaac gtattttttt ctatacaaaa 330241 agaccccgta tggatatgat taaagtaaaa aaagtatagg agaaaaaggt atggaagagc 330301 ttttagagag agttttttca ttttcagatg ttgataagct aattgatttt attagctatg 330361 aactgcaaaa gccagtgata ctggaaagcg cggatttctt tttgttagcc tataattctt 330421 actatattaa ccattttgat tctgccaacc agcagactat tttttcgaaa aagtgtccgg 330481 tccagatttt tgagaggttt ctgaaggacg gaattattga aaaattgaaa acagagcctg 330541 agccttttcg cgtcaataaa attgaaagca ttgggttaaa ccagagggtg gtcgtgagtg 330601 caaagcacaa aggggaagtc atgggctaca tctggattca ggagctggac caaaatctga 330661 cggatgaaga gctcgacttt ttgtacgaga cctccttcca tgtcgggaaa atcatttata 330721 aaacgaataa attgaaacag gaaaaggaag aaaaagcaga ggatctcatc aaacgggcga 330781 tctatcagca atttacctct gagaaggaac tcagacggga agctgaaagg atcaacaccg 330841 tgctgccttc catgttttca gttgttatcc tgcacgccgc aaatggggat ggggaagcgg 330901 ttgaggattt aaaggaaaat atcaggtcgt acctgaattt acgggataag gtcagtcatg 330961 tcttaacgat cgaatcaaac attgtcatcg tcgtagcgag tttttcccaa aaaagctccg 331021 tctcctcagc agcttctgag tttattaaca agctgttaac acattttcac tttcaaaaaa 331081 tacctacccc tatttatatc ggtatcggaa acgaatataa tcacctatta aaacttggca 331141 agagctacac agaagcactt gaagtcatca aagccgcaga aatcaccggc aatcaggaaa 331201 acattccata tgaatatgcc aaactcggca tttaccgcta tttagaaagc atcgaacaga 331261 aaaatgaatt tttagaatac gagaataaag atttagcttt attaaaagca aaagacgaag 331321 aaagcagcac tgagctgctc aaaaccttgg aaatctatct cctcaacaac tgcaaaacaa 331381 aaccagcggc agaacagctg tttattcacc aaaatacatt gaattaccgc atcaaacaga 331441 ttactgagat gacgtcgatc gatttaagcg atttcagaac gcggtgccag ctctatctcg 331501 atttgatgct gatgaaaaag aaataaaaaa gaaaccagta cttgtactgg tttcgtcttc 331561 acttaaaatc ctctgtaaac atacggatca tcaggttttt taatggtatt ccagtcagtt 331621 actttgacga cagggagagt tgacttgaat ggctggtaat attctgaggc cagagtgccc 331681 ttaatgtgaa tccattcatc atccttgatg tccatgtcct tcggaaattc cacaagcatc 331741 ccgtacacgc cggaatcagc gatacagtga atgatgccaa accttaatac gaacagctga 331801 tttttgttaa ttgcgtttcc tttgtaagca aatccatgaa attctatcgt ccgtccgaga 331861 aattcacccg gatagttata gatggtttcc attcctttta ggaaatcgtc atcggtcaga 331921 gaaatctctt ttttgctgga atacttatta aacagctgtt tcatttgttt gtcatagctg 331981 tcttgcgcgt aataaaggct ggcatcaggc cgcaaatact gtgtttggga gtagtgatct 332041 ccgctctcca tcgccttaaa cgagaaccct tttgttttga ctatggatga gtcaagcgtt 332101 gcaatcggga agaagatgcc tgacaccaaa ggaaaaagaa aaacaacata aatcaaataa 332161 cgctgataaa atggcttgtt ttgttcatgg tcatgctcgt gatcatggcc gcacccgcaa 332221 tcatggtcat ggtgatgtcc gcttttttca ggcgacttga taaatagata tgcttggacg 332281 gcggtcagaa tggccagcag gaagatcgca ataaaggaaa gataggcata tttcatattg 332341 atatattttg ttagatttcc tgaggcatgc agatgataaa agaaaaacgt aaatcccatc 332401 agcaccaata aacgaaacat ccaatcaccc ctttaccagt agtgatcccg ctaaaacaat 332461 cacgacaatg tatgtaatca gcaggaaaac aaatcgtttt ttgaaggccg caagcatcat 332521 caatagattc ttaatatcca ccattgcacc aaagacgaga aaggcgatta acgatcctaa 332581 tgaaaacgtg ctgctgaagg aagacgcgat gaacgcatca acttctgaac aaagcgacag 332641 gacaaacgcc agacccatca tcacgaggga agaggataca tcattctgcc cgatcgcaag 332701 cagagtggat gttttgacat acgtctgcat agcggctgcg ataaaggcgc cgatgattaa 332761 atatttcccc acggagaaaa attcatcaat ggcatgccgc aaggtcccgc ccagtttttg 332821 gagcaaggtg ccgtgatgat gatggtggtg cccgggttca tcaggcttta aaagctggtt 332881 atccttaaat tgataggata agatgacccc gatgatcagc gaaacggcga gagccagtcc 332941 gcctctgtaa aagaccacgc tccatctatt cccgaacgca atataagtag aaaataaaac 333001 gataggatta atgataggcg cggtcagcat gaaagcaacg cccgcatgca gaggaactcc 333061 ctttaacaga agccgcctcg taatcgggat gatgccgcat tcgcaggcgg gaaataaaac 333121 gccggccagc gcaccgaata aaacggcgag aaaacggttt ttcggcatga ttcttgcaat 333181 catttcttca gaaacaaaca tttgaatgat tccggaaagt atgacgccaa tcagaataaa 333241 cggaatggct tctattaaaa tgctgataaa aatagaattc agctgaagaa aagatgattg 333301 tgctgtcaca ataaaacctc cgctcatgtt aagctgcctt tcttatgata ccagaaaaaa 333361 aggcactgct tgtttgacgg aggaggggaa aggatcgttt cactttggtt aggattccaa 333421 aaagccgagt aggatactgc ctgtttctgc agcttctttt ccgagccaaa tcaggtgtcc 333481 ccatgagtga agcaaacaga gaacagcgcc acgaatgtgc tcttttgcat gatgtgcatg 333541 tgacaagtca accaatccgt cataaacact ttgcataatc agcacgggac atatgatggc 333601 ttgcaggtct tttaaagaga cagcggcggt ttgtgacaag tcaatcagaa atccttcacc 333661 cgagcgctgc cggctgttca ttttccgaaa tgcttctatg tctttttcat tcatcaagga 333721 cttgattcgc tgaaacggaa gcgtgctgaa ttgggggctc atagctcgaa acatcaaacg 333781 cgggaaagcg ttattcaagg aagaaatcag cttccatatc cacttttcca ccggcgggcg 333841 gaagagaatt tcccccaatt tatattcagt gtcttttggg gtgagccact ctttggtgac 333901 tgcggattgc agggtcaatg tatttactct ttccggataa tgtgaggcaa agcatatgcc 333961 gctcggccct cctgctgaga tggcgatcac atggacactc tcgatttgta gatgatctaa 334021 taatttcaca tagaaacggc aggcattggc aagacttttt ccaatttctt ttgacgtccg 334081 tccatagcca ggccttgaag gcgtaatgat ggaataccct tgttcaatca acgctgtgta 334141 tccgaattcc tcgtaacaat ttgaatgccc gccatgcatg acaaggatcg gagttccctt 334201 gcctgtcaca gaatattcta gtgtaccgcc atcgaaggtg atcgtttcaa ctcgtctttt 334261 catctgtttc acccaattgg tttttgccta ttatagagtt ttcagcaatt gaccacaagg 334321 tagaagaaat gaataaacaa aggcccttga aatatgatat actttgtatt gatattcatt 334381 ctcaattaaa actttgatat agatgtgaac gggaggcagg acggatggct gagaatcaag 334441 aggtatatga cgttacgatt ataggcgggg ggccgatcgg gctgtttact gctttttact 334501 gcgggatgcg ggagctgaaa acaaaggtaa tcgaattttt gccgaagctc ggagggaagg 334561 tgtctttatt ctttcctgag aaaatcattc gcgatatcgg cggcataccg gggattgcgg 334621 gaaagcagct gatcgagcag ctgaaggagc aggcggcaac gtttgatcct gatatcgtat 334681 tgaatcagcg tgtgaccggg tttgaacgcc tagatgacgg caccattgtt ctgacgggtt 334741 ctgaagggaa aaagcactat acaagaactg tgattttggc ttgcggcatg ggtacacttg 334801 aggtcaatga gtttgacagc gaggatgcgg cccgatatgc gggcaaaaat cttcattatg 334861 gagtggagaa gctcgatgcg tttaaaggga aacgcgtggt gatatcaggc ggcggagata 334921 ctgcggtcga ttgggctaat gagcttgaac cgattgcggc gtctgtgact gtcgttcatc 334981 ggcgtgagga attcggcgga atggaaagca gcgtgacgaa aatgaagcaa tcatcggtgc 335041 gggtgcttac gccttatcgg ctggagcagt tgaacggaga tgaagagggc atcaaaagcg 335101 tgaccgtttg tcatactgag tctggccaga ggaaagacat agaaattgat gagctgatca 335161 ttaatcatgg gttcaaaatt gatctcgggc cgatgatgga gtgggggctg gagattgaag 335221 aaggaagggt gaaagctgac agacatatgc gaacgaatct tccgggcgtg tttgtggcgg 335281 gcgacgcggc tttttatgaa agcaagctga gattgattgc cggcggattt acggaaggcc 335341 cgacagcggt caacagtgcc aaggcttatc tggaccctaa ggccgagaat atggcgatgt 335401 attccaccca tcataaaaaa ttggtgcata aataaaacag cccttgagga aaagggctgc 335461 ttgccatcag gtgtgaagga gttttttctc tgcatgttga ttgtggatga aagctagcaa 335521 ttcatcctgt tcttgtacgg ctgtgaatcc ataaatgccg gcagctgagt catcgcctat 335581 gcagacgata ggagggcggc ttgctgacgg ttccggcaaa atgccaattt gttcgccacc 335641 attgatcaat tgctgaacgg acagcttgtt tgggcaaatg accatgtgca gcggggattc 335701 actgatggta cgctgaatca tgtgggtgaa ccggtcatct atgacgtttt catgagtgat 335761 ataaaacgaa caggattcat gcttttgcat gttttccact gcatggcggc tcccgacaac 335821 aagacgtttc tctgaatcag gctgaatggc ggtgacaaga aagccccgtt tctcaagctc 335881 tgtctttgct tgctcagatg ctgcactcag tttggctgtc agctggcgga tgtcgatttt 335941 ctgagaagcc agtgctctga aaaattcaca aaccgcccgg cgcgatgtga aaaaaacgtc 336001 ttcaaaggtg ccaatctttc gaagaatttc ttcattgaca ggcatgtttt cggtccgcca 336061 tttcggccac tcgatgagat cggcgccgga atcgcgcagc ttgtctgcaa gcgggtcttc 336121 atcttcgcca tgagtcacaa ccatcaaatg ccgtccgatg agcggtttgc tttcaaacca 336181 gctgtgtgtt tgaaagttga cgatgtctcc gatgacgata atcgcagggt ttgtaatctg 336241 gtgttcctgc actttttgct gaatgttctc aagtgttcct ttcacactcc gctggcggcc 336301 ccacgttccc cattggatga caatgacagg gacagaaggc gatttcccgt atgaaataag 336361 ctgctggcaa atataagaca agttcttgac acccatgtaa aaaacaaggg tttgaacgct 336421 tcgggccagc ccttcccagt caaggttcgg cgtgcctttt aatgatttat catgcgctgt 336481 aatcatggca aaagacgatg caaaatcccg atgcgtgacg gggatgcccg catatagcgg 336541 cgctgcaatt ccagaggtga ttcccggcac catttcatag cgaatgccgt gctcatgaag 336601 agcatctgct tcctcgccga ctctgccgaa tacgctcgga tctccgccct tcaagcgaac 336661 gacggttaac ccatttaatg ctttttcaac cagcagggcg ttaatttctt tttgtttcat 336721 aaaatggcgg tttggcagtt ttccgcaata aataaactgg cagtccggtg atgcaaattc 336781 gagcagcttc gggttggcga gccggtcata taaaatcaca tctgcttcct tgagcgcctg 336841 ttttcctttg atggtgagca ggcctgggtc gccgggtccg gctcccacga aatatacgat 336901 tccgttcttc atgatcatgt catccttccg tcactgtaaa aaatgaagga ccactagaaa 336961 agtgatccgg tcttttgatc aatatacgag ataaacatgt tctccttcga tcagcgtttc 337021 atatgttttg acgcatccgt ggtcaggttc ttggacgatt ccgtcttcta aggaaatttt 337081 ccagtcgtgc atcgggcaga aaacatattg accgctgacg atgccttctg ccaggacgcc 337141 gcccttatgc ggacagcggt tttcaatggc gcggatgctt ccgtctgaaa gcttgaaaac 337201 cgcgagctcc ttatcttcaa tatacactgt tttgcctaat tgttcaggca attcttcaat 337261 ttttccgata catacttttg ttacgtcttt gtttaccatg tccattcctc ctcaatgata 337321 gtttttgtca ttatgatgtg gtcacgacat tttcaaataa ttctttagag gtttgtttat 337381 cctctaaaaa gtctttccac ggatccttgt ggacagagag tgtttcattc attcggccgt 337441 tcagctcctg ccgcttttcc ggatcgttta acacggattg gacatgggat aaaccgacgc 337501 gctcaagcca tgcggacgta cgctccagat agtttgcggt ttccctgtaa tattgcaggt 337561 aagcgcccgc gtattctaag acttcttcat ttgttttcac cttcatcagc aaatcgccgg 337621 cacgcaaatg ggttccgccg tttccgccga cataaagctc ccagcctccg tcgatgccga 337681 caacgccaag gtccttaatg ccggattccg cacagtttcg cgggcaggca gacacggcca 337741 ttttgacttt gtgaggcgtg ttcagccctt cgaatttttt ctcaagcgca atgcccagtg 337801 ccatggagtc ttgtgtgccg aagcggcaga attgctcgcc tacacatgtt ttcactgtgc 337861 ggagcgtttt tccgtacgcg tagcccgatg gcatatcaag atcttcccat accttcggaa 337921 ggtcttcttt tttcacgccg ataagatcaa ttcgctggcc gcctgtcatt ttcacgagcg 337981 ggatctcata tttgtcaacg acatcggcga tcttgcgcaa atctgtggag ttggtcacgc 338041 cgccgtacat ccgaggaacg actgagtatg ttccgtcttt ttgaatattg gcgtgcattc 338101 gttcattaac aaagcgggat gtccggtcat cctcgtattt ggttggattg atcatgccta 338161 agtagtagtt cagagcgggt cggcatttag aacagccttc tggcgttttc cagccgagca 338221 cattcatgac ttctcttgta tgtgacagcc ctttggcttt gatttcttct acgacttcat 338281 ctctcgacaa tgtggtgcag ccgcaaatgg cttctttttg cgctgacgca tcaaagtctg 338341 atccgagcgt atgctggagg atttcttcta cgagcggctt acagcctccg catgagcggg 338401 atgcgccggt gcatgctttg atttcgtccg ttgacgagca gcccttttcc tgtatggctt 338461 gaataatcgc accttttgac acgccgttac agccgcagat gatttcatcg tcgctcatcg 338521 ctgcggttat gcttgtgcct gcttcctggc tgaggggctg taagattgat attttagagg 338581 tttcagagat atcggcttct ttttgaatca tagaaaacag gcgattgcct tcgctgctgt 338641 cgccgaataa aacagcaccg acaatttgat tgcctctcag gacaattttt ttatagatgc 338701 cgtcctgctc atcgaagact ttaatcgctt ttttctcctc tgattcgtta aagtcaccgg 338761 cagagaagac ctcgacgcct gataccttta actgtgtgga gagaacggag ccctcatacg 338821 gttttgtttc gatgccgcac atatgctttg ccagcacttt tgcctgttca tacagcggcg 338881 ccacaagccc gtaggcgatt cctcggtgct cggcacattc gccgaccgcg taaatgtgcg 338941 ggatttcagt ctgcatataa tcgttgacga tgatgccgcg gttaaccgga atgccgctct 339001 cggccccgag cgttgtattt gggcggatgc cgacagccat gacgactaaa tcagcttcaa 339061 tgcttgtgcc atccttgaat cggaggcctt cgacacggtc gtcaccgaca atttcttctg 339121 tttgcttttc aagtaaaaag gtcatacctt gtttttctaa ctcgttttgc agcaggcgtc 339181 ctgccgttgc atcaagctgg cgctccatca ggaatggggc aaggtggatg acggacacgt 339241 ccatgccgag attcagcagt ccgcgagctg cttccaaacc aagtagtcct ccgccgatga 339301 cggcagcttt tttatattgt tttgacgcgg cgagcattgt gtctgtatct tttatgtccc 339361 ggaaagctgt gacgcctttt ttgtctgcgc ccggaatcgg aaggataaaa gggaccgatc 339421 ctgtcgccag gatcaattca tcgtaaggct ggattctgtc tgcatctgtg atgactgttt 339481 tgttttccgt gtccactttg atgactgttt catttgtata caattgaatg ttgttttctt 339541 cgtaccagtc ccaatcgttt aacgtaatat ctttaatatc tgtatcgcct tgaagcactt 339601 ttgacaaaag gattcggttg taattgggat gcggttcggc accgaaaatt gtgatctgaa 339661 actcgtcttt agcaacactc agtatctctt caatggccct taccccggcc attccattac 339721 caacaagaac tagctgtttt tttcccatca gatgatccgc tccttatcaa atgttttttc 339781 cagcgtagca cagcaaaaag gaatatttaa gatacatgtt ataaaatgta acaaaatata 339841 cgaaaagttc taaaaatttt atgaaaaatt taaataggta tgattcggac ggcgcatacc 339901 ttaaaaccgg gcattttaca ggctggatct aaggcttccc cgattaaatc attcacattt 339961 tgagcgtctg cccaatggat gggaacaaaa acggtatctt ttctgatttg ttctgataat 340021 ttgctgcgga cggtgatgct tccccgcggc gattctattt ttaccagtac acggtcctcg 340081 atattgtagg tcgctgctgt ttgcggatgg atctccataa acgattcaaa atgtctcgcg 340141 gcaagggcgg cgctttttct tgtttggacg cctgttaagt agtgagacat gactctgcct 340201 gtcgttaaat aaagcggata atcggctgtc ggcttctctt ttggaacagg tggttcgttt 340261 ggaatcacac ttaatgccgc tttttgatcc ggatgagcaa atgattctgt aaacaagcgc 340321 ccagttccgg gatgatcaga ttccggacac ggccaatgaa tgccgccttc acgtctgagc 340381 ctgccgtatg agatgcctga ataatcggca atcccgcctc ggctcgcttc tctcaattca 340441 ttgaaaatat cctccgctga cgtataagaa aagtagcggc ccttgccgag agcggatgcg 340501 agatcacaaa tgatctgcca atcatgcttt gcttcgccgg ggcatggccg gcttgcttct 340561 cttaatgtca cgcgtccttc tacatttgtc atggtgcctt catcttctaa gtaagaggag 340621 gcaggtaaaa tcacatctgc gtatttcgca gtctcagaaa taaacaaatc gattgcgaca 340681 aagaatgtca gtcttcttaa agcctttttc acgagatttg catttggact ggaaacagca 340741 gggttggagc acatgaggaa cagtcctttg atgtcgccgt cattgatttt ttccatcatt 340801 tcataggctg agacaccttt tcgcgggagt tcatcctgat ggattcccca cactttcgca 340861 atatgcgccc ggtgttcttc gttttcgata gaacggtagc ctggaagctg atcggctttt 340921 tggccatgct ctctggcgcc ttgcccgttg ccttgtccgg tgatcgcccc gtagcccgag 340981 taaggtttgc cgatttttcc tgtgatcagc accatgttta agaagccttt cacagccgct 341041 gttccatcgg tttgctgttc aatcccgcgg gctgtaaaca gcatgccgga cgtttccttg 341101 gcaaacttca cagcagcttt tcttatatcc accagcgaga cactcgtctg ttcggcgatg 341161 tcattcaggt ccaacgagtc agtatgctgc ttcagctctt cgaatccatt tgttcgtgat 341221 tgaatgaaat cctcgtttat aagctgttcg tcaatgatga ttttgacgag accgttggca 341281 agggcggcgt ctgtgccggg tttgattttc agatgaagat cggcgatttt cgttgtcgct 341341 gtttcacgag gatcaatggc aatgaagtaa gctccgtttt ctttcgcttt ttcaaaatac 341401 ggcataatcg taggctggca ttccgcaata ttggtgccgg ccagaatgat cacacgggtg 341461 tgggggatgt ctgataaagg attcgttaag cctctgtccg cgccgaatgt ttggttggct 341521 gcggtggctg ctgcggacat acaaagtctc ccgttgtagt cgatgtattt tgtctgtaag 341581 cctactcgtg cgaacttccc taacaaatac gcctcttcat ttgtaatcga ggcgcttccg 341641 tataccgcca tggcgtcatg tccgtgttca gtttggatca ttgtcacttg gtctttgata 341701 tgattcagtg cttcttccca ggaaacaggc ataaactcgc cgtttttctt cagcagcggc 341761 cgggtgatgc gggaggagtt caaggcatgc tggtgagcat tcatgccctt gatgcatagc 341821 cgaccctgtg tcgtaggatt atcaatcccg atcgcagtgt actttttgcg cgtgacgatg 341881 gtttgttcca cgagctgcat tttgcactgc atgctgcaaa acgggcattg agtgtcatat 341941 gttttttctg attggacgtc ttgctgttta tcacggaaat atctaagcag tcgttcagtc 342001 aaaatgcctc atcctttctt atatgcgccc gtctctacag tcgggttttg aatcagtgac 342061 agatctgttt ggaggctttc cagcagctgt gcccttaggt cttcttcgaa tagcacttct 342121 ctgatatgaa cgatcccgag acggtctatc cactgatgaa caccttctaa gtaatgagcc 342181 gtttcccgat aatactggat cagtcctttg atcatgccgg cagtgctgtc ttcgttctca 342241 gtcacgcaaa acaaagctcc tgaacgggca tgagttcccc ggacgccgcc gatgtgaatg 342301 tcccagccag cttgtgtccg aattgcgccg acatcttgca gggcggcctc ggtgcagtct 342361 gtttcacatg ataagctgat agaaatggga gcgggtaagg gaagcatctc aagttgtctt 342421 tcgatttggg ctgccagctg ctgaatcgat cgattttgcc cgcatgtaca tgctttgatg 342481 ctttgcagcg cgtgtcggtg ttcattagtg taaacgggca ttttcaggtc ttttttcatg 342541 ttcgggagat ccgcaggctt gatcccggaa agcttcagcc tttggccgtg agtgatggat 342601 acgtcgggaa tgctgtatgc ctcaatgatg ttggcgatgg ttcttagctg ctccgcgttt 342661 gtccgcccgc cgtacatttg cggaatcagg atgcatgtct cttcagtggc tggctcaggc 342721 tggacaaacc cagggtacag catttccaga tagtattgaa tcgcaggaac acaagtactg 342781 catccgtttt ttgttttcca gtcaagctgg ttcatcactt ctgccggatt agtgaatggc 342841 ctgcgctgaa gctcagcgat gatgtcgtct tctgtaaaat cagtacagct gcaaaacgaa 342901 ggtgtgctgg cgggcttcgt atattcgctg ttggtcatgt atctcaaaag gtcttcaacg 342961 agcggtttgc atcctccgca ggacccagtg gctttggtgc agtgcttgac ttcctcaaca 343021 gttgttaagc tattcgtgtg caccgcgtct tcaatcgcgc ctttcgtcac tgtgttgcat 343081 tggcaaatcg tttcactgga aggcatggat tcaaataaag ggccgcttgt ctccggttcg 343141 atgatctgtt ttttggcaat ggagatgtct cgttgtttaa gcaggctgtc gagaagccgc 343201 tgcttgtcac gggtgtctcc gaataaaata acgccggcca gtttgtcatc tacaaaaagc 343261 gcttttttat aaacgcctgc ttgttcgtcg tagattttga tgctcgtcgt gcgttcatcc 343321 tcttggatct ttcctgctga ccacacatcg attccagcta tttttaacgc cgcagatggt 343381 gctgagcctt gatattcctc acatggaacg ccgcaaatat gactggcgag cgcttttccc 343441 tgctcataaa gcggagccac caatccgtac accgttccgt tatgctcagc gcattcacca 343501 acggcgtaga tattcggttc gcttgtctgc atgaagtcat tcacgatgat cccgcggttc 343561 actttgattc cagcggatac agccaattca atattcggtt tgacgccggc cgccatcaca 343621 atcaagtctg cttttaatga agagccatct ttaaaatgga ttcggtctgc cttcgtggcg 343681 ccggaaatgg agacggtgtc tttctccaaa agaaaggtta ggcctttttg ttccagctct 343741 gtttgcagca gccgcgccgc tgtttgatcg agctgttttt gcataatgcc ggcggagtgg 343801 tgaatgacgc tgacatccat accgagatgc tgtaaaccta ctgcagcttc cagtcctaat 343861 aagccggctc cgattaccgc agccttttga aagtgctggg ccatgttcat cagcgcttgg 343921 cagtcttcta ttgtccgaaa tccatagaca ccttttttgt ctgccccggg gatagggaga 343981 atatgagggg aggagcctgt tgccactatt aatttgtcat acgacagagt gcgtttccga 344041 tctgtgatga cctgctgctg atctgtatca atctgaataa ccgtttcgcc tgtgtaaagc 344101 gtgatcccgt gcttgtcgta ccaatccttg ctgttcagtg taatatcatc gagtgacgct 344161 tcaccctgca atacagagga taagagaatg cgattgtaat tgggatgcgg ctcgcttccg 344221 aaaatgacaa tctcaaacat gtggcgattc agctttaata cttcttcaat acagcggatt 344281 ccggccatgc cgtttcccgc taacactaat ctttgtttct tcatgtatca gacctccttt 344341 ggcgaagctc gtaagttttc tcctattaaa aattatgtca caatgcattg ttaacgcatt 344401 aaacgtgtca caaaaactta cacatgtctt ttccagaaaa taatggtcct atatccttga 344461 ttcagaaaat gtaaaataat gagggtctag aaaggggaat cttatgaagc tgtcggaact 344521 gaaaactagc ggtcatccac tcactttgct ctgttccttt ttatactttg atgtcagttt 344581 tatgatatgg gttatgcttg gggcgctggg tgtttatatt tctcaggatt ttggcctgtc 344641 tccttttgag aaagggcttg tcgtagctgt gccgatttta tctggatctg tgtttcgtat 344701 cattcttggt attttaacgg acagaatcgg accgaaaaaa acggcagtga tcgggatgct 344761 ggtgacgatg attccgctgc tttgggggac attcggcggc cgttccctga ctgagctgta 344821 tgccatcggg attctgcttg gcgtggcggg agcaagcttt gctgtagcgc tgcctatggc 344881 cagccgctgg tatccgcctc atttgcaggg acttgcgatg gggattgccg gagcggggaa 344941 cagcggcacg ttgtttgcaa ccctgtttgg ccctcgtctg gcagagcagt tcggctggca 345001 cattgtcatg ggaattgcgc taattccatt attgatcgtc tttattcttt ttgtatccat 345061 ggcaaaggat tcccctgcac agccgtctcc ccagccgctc aaaagctatc tgcatgtgtt 345121 tgggcaaaag gaaacatggt ttttctgcct gctgtacagc gtcacatttg gcggatttgt 345181 cgggctctca agctttttat ctattttctt tgttgatcaa taccagctgt caaaaattca 345241 cgcaggggac ttcgttacat tatgtgtggc ggcggggagc tttttccggc ctgtcggggg 345301 cttgatttca gatcgtgtcg gcggcacgaa agttctttct gtattgtttg tcatcgtggc 345361 actgtgtatg gccggagtca gtagcctgcc atctctctca atggttattg ttctattgtt 345421 tgtcggaatg atggggctcg gaatgggaaa cggcgcagta ttccagctcg tgccgcagcg 345481 cttccgcaaa gaaatcggca tggtgacggg aatcgtcggt gcggccggag gaatcggagg 345541 gtttttcttg ccgaacatct taggatctct caaacagatg acaggcacat atgctatcgg 345601 ttttatcacg ttttcctgta tcgcgctgct ggcgtttgca cttgtgcttg ccgcaggcta 345661 ttactggcgg aaaagctgga gcgcggaaag cagcccggcg gatgtttagg attttgacgg 345721 acacgcgttt gtgcgtgtct tttttatttt ctcttgattt tcaacagtga accgatcaaa 345781 ataaatagta attattacga tttgttagtg agaggagttt tctgaatgaa tcaacatacg 345841 ctgctcccga aaaaaacgga gcgtcttcaa tactttggat cggtcagtcc gatcaaaggc 345901 gagaaaccag tggaaaaaga gaaaatgaag gacctgcaaa atatcaggaa ggattatttt 345961 tttgacattc agcatgtagg tgtagctaat gtgtcccatc cagtcacaat cacttctgcc 346021 atgatgcctg ccgagcaaac aacggctgcg aactttacaa tgacttgtaa tttgccgaga 346081 aatcagaagg ggattaacat gagccggtta acagagctgc tgcaagtcta tcatcaaaat 346141 ggctggattc tctcattttc ctctcttcag caatttacga aagagcttgc agaaaacatg 346201 gacacatcat ctgccacagt tgaagtgagg tttccgtggt ttttcgaacg gaaaagcccg 346261 aagcttgaga aagcgggttt gatgcatgct gatatattca tgtctgtcac ctatcgcaaa 346321 gatcagccgt ttaaacagcg tgccggcatc tcagcaaaag taacgactct gtgcccttgc 346381 tccaaggaaa tcagcgaata cagtgcccat aatcagaggg gaacggtcag catttgggcg 346441 gatattcacc cggccgcatc gctgccaagt gatgttaaag ctgatttgct tcacgccgca 346501 gaatcaaatg cttctgcgag actgcatccg gtattgaagc ggcctgatga aaaagccgtg 346561 acagaaacgg cctatgaaaa cccgagattt gttgaggatc tcgcccggct gattgctgca 346621 gatttgtttg agcttgaatg ggtgtcagcc tttgagattg aatgccgaaa tgaagaatcg 346681 atccatcttc acgatgccta tgcgaagctg tgtttttcga aggaagtgga taaaatatga 346741 aactctcatt attcattatt gcagttctta tgccagtcat cctgctgtca gcctgctccg 346801 atcatgcaga agaacacgca agtatcaata caaagaaaac ggtcgaaaac ataacggacg 346861 ttcgaaaaac agcaaaaaca agcattgatt ggacaaagcc ttcgggcgga gaatacccgg 346921 atattaaaca gaagcatgtc tggattgatg tgaatgtgaa ggagcagaag gcttacatca 346981 aggaaggaag caacaccatc tatacaatga tgatttcttc tggtcttgat caaacaaaag 347041 atgatgctac gccaaagggc accttttatg tagagcctga acggggagaa tggtttttct 347101 ccgaaggata ccaggaaggc gcagaatact gggtatcatg gaaaaatcac ggtgaatttt 347161 tatttcatag tgtgccaatg actaaggatc aaaaagtcat caaaacggaa gcagaaaaac 347221 taggaacgaa agcatctcac ggatgtatca ggctgaccat tccagatgcg aaatgggtat 347281 atgaaaatat ccctgaacat acaaaagtgg tgatcagctg aattgaaaac cgttgacaaa 347341 aaggaaaaaa gaccatacaa tttaaatcgt aacaattacg ttttatgata aatggcttat 347401 cattgtctgt gcatctgtga aaagcggaaa ggcatcgatt aaggatcttg ctgtcggcaa 347461 aggcaaggat ttgcgatggg gaaaaggatt aaacgcggtt ggagtcttta ctgatttaga 347521 aatcgggcgg cagcgagaaa tgagcgcgaa aagctgctct acaccattgt acatacggcg 347581 aagtattcaa tttaaatcgt aatcattcta ttttaatgga ggcactatta tgaaaaaaat 347641 tccggttacc gtactgagcg gttatctcgg tgcgggaaaa acaacattgc tgaacagcat 347701 tttgcaaaat cgcgaaggct tgaaaatagc ggttatcgta aacgatatga gcgaggtgaa 347761 cattgacgcg ggcttggtta agcaggaagg tggcctttcc agaacagatg aaaagcttgt 347821 ggaaatgtca aatggctgca tttgctgcac gcttcgcgaa gacttattaa ttgaagttga 347881 gaagctggca aaagacggac ggtttgatta tatcgtcatc gaatcgacag gaatcagcga 347941 accgatcccg gtggcccaga ctttctctta tatcgatgaa gagatgggaa tcgatcttac 348001 aaaattctgt cagctggata cgatggtgac ggttgttgat gccaaccgtt tttggcatga 348061 ttatcagtca ggcgaaagcc ttctggaccg caaagaagca ttgggggaaa aggatgaaag 348121 agaaatcgcc gacctcttga tcgatcaaat tgagttttgc gatgtactga tcttaaataa 348181 atgtgatttg gtcagcgagc aagagctcga acagcttgaa aacgttcttc gtaaactgca 348241 gccaagagcc aggttcattc gttccgtcaa aggaaatgta aaaccgcagg agattttgca 348301 tacagggtta tttaacttcg aggaagcgag cggatcggcc ggctggattc aagagctgac 348361 ggcaggccat gcggaacaca ccccggaaac agaagaatac ggtatctctt catttgtata 348421 taagagacgt ttgccgtttc attctacacg attttaccgt tggttggatc aaatgccaaa 348481 gaacgtggta cgtgccaaag gaatcgtctg gtgcgcatct cataacaacc tcgctttgct 348541 gatgtcgcaa gcaggtccgt cggttacgat tgagcctgta tcttattggg tggcggcgtt 348601 gccgaagctt gagcaggagc aagtcaaaca gcaggagccg gaaatcctgg aggagtggga 348661 cccggagttc ggcgaccgcc taacgcagct agtttttatc ggaactgacc tggatgaaga 348721 aacgatcacg aaagagcttg atcaatgcct gttgactgag tatgaatttg attccgactg 348781 gtcgctgttt gaggacccgt ttaaatggaa gctgaatcaa tagaaaaaaa gccgtcccat 348841 ggggaacggc tttttttaat gaaacgtttg tttaaacata atgagcgtat tttttctcaa 348901 ggatattctg aaagaccgcg gcaatggagc agatggccca ataaatgaga gcggtcagaa 348961 tatacatggt catataatca aactctctgc ccccgatgat tttcgcatgc tggagcaatt 349021 ccggcactgt aatcatcgca gcgagagagg acgccttgat caagtcgagc aatacattgg 349081 caagcggagg cagcgcaata cgtatcgatt gcggcaaaat gatgcccctc atcgtctgcc 349141 aataggaaag acccagcgag gatgcggctt cccactgtcc tttttcgacg gatgaaatgg 349201 ctgaacggtt aatttccgca atgtaggcgg cgctgtttag gctaaagccg attaaagcag 349261 ccgtgacagc ggaaaattca atgccgatat aaggaaaccc gaaataaagg ataaacaaaa 349321 tcaccaaaat cggaacgcct cgcataaatg agatatagag cttcgccggc catcttaaca 349381 aagcaagttt agacattctg gcgagtgata tgaacaggcc gatcacagtt cccgcaaaca 349441 tgcttacaaa agagatgagc agtgtataac caatgccttt tatgacataa gggaacgatt 349501 caatggccag cttcgtgttg aaaatatatt cccactgaat gctattgatc atggcgtccg 349561 attacaaatc aacgtcctga acgtcggcat caattttttt tgatacatct gctttattga 349621 agaattgttt cgacagttta gtcaaagagc catccttgct catctctttc aatgcttcgt 349681 tcatcttttt ctgaagtgcc gcattgcttt ttttcatgac aagggcctgt ttgttcggca 349741 tgtacttgat gtcaggatga attgtaatgt tgagatccgg gaatgccgcg agcgcaagtg 349801 tctgcaggta atagtcgttt aaaatgacgt cagtgcgtcc gttggcaaca tcttttaaat 349861 attgctcatt cgtcgcatta tcataaatca cttctttggc gccgtatttt ctcgcgacct 349921 ccatgtagac ggttgtagcc gcgccagccg ctttcttccc ttttaaatcc ttgagcgttt 349981 taatccctga taaatcgtct tttcggacaa ttgccgtgcc gtatgaatat ttatatggag 350041 tggaaaatgc gaacttctcc tcacggtcct tcgtcacatc gatgtcattc gcggctgcgt 350101 caacctgtcc gctgttcacc gctgtcagca tcccgtcaat gcccatctcc ttgaactcaa 350161 ccttcagccc caagcgtttt gccgcttcac gaacaacttc aacctcgtag cccgtcagct 350221 tatcagagcc agagtcagta tcgtgataag aagtgggata gagcgtacct gatgtagcga 350281 ctacgatttt ccctttatcc ttaatctgct cccagcctgt atccttggaa tcggcttcat 350341 ttttgccgga acaggctgcc aatataagaa agaaagccat tgtgaaactg aatataacgg 350401 ctttggaatg catgaatgat ttcacctata gttcccccaa tctgttaatc aactaaaaag 350461 atagcattga acataagggg ttgcaatatg ttgatcgcgt tttcaaaaag ttcgaattgt 350521 gtatacaaaa agcatgggtg ggtgtttaaa agcgtctatg aagggaagag gtgatgaaaa 350581 aaggaattgt ccaaggatga atgccagacg taccaaggaa acgcatgtga aagtgaagga 350641 tgcagcagac ccgtcactca tctatgccaa taccggaaga aatggtcaag aggcatgaaa 350701 ccgatcttca gaataaattt aagtcttgct gatgccccta aggcatatga tatattcgat 350761 gagaaagaaa atggaaacat ttaaaccata atggggagtc aaatgaatat ttacaaacca 350821 gccggatttt ggatcagact tggagctgca ttgttagact acattatagt ctccgtgccg 350881 cttttgctga tctattggct gattacagga aaagacccaa acgacagcat gttcatcagt 350941 ttggttgttc tgctgtattc tattttgctg ccgatgtttt ggcgcggtta tcttatcgga 351001 aaaaggatct gcggaatcag aatcgtaaaa aaagacggat cacaggtcag tctgttaaca 351061 atgtttttac gggttattgt agccggcctg gtttactgta taaccttcgg actcggcttg 351121 atcgccagcc tgattctgat tgccgtacga gaagacaaac ggaccctgca tgatttaatc 351181 gcgggaacat atgtcactta tgcgacacca ggtgaagagg aacttaatgc tgacgaagag 351241 attagaaaga gcgaataatg gttcgctctt tttattttta tgcataaaaa atacaaggca 351301 gcaaaacata tgaaaaatag gattggagga ataaaatgga tgaaacgaat aaccatcaac 351361 attatcacaa tgttcattgc agcggctgtc atttctctga ccggtacagc tgaggccgct 351421 gaaaaacagc agcagtctcc cgcaaatgtt acactgacag atcagcaaaa gaaagagatt 351481 gaacaactgg aagcagagat tcttaaaaag cgcaaagacg tgatctcaaa gtatgtacaa 351541 tacggtatcc tgcctaaaga aagaggagaa cacatcaaaa atcacttgga caaacacttt 351601 gaaatgatga aacaaaacgg ctttgttcca aagcaccatc ctcatccgca taaatttgaa 351661 aaaagacatt aagattttaa gcatccaatg ggaattgggt gcttttgcgt tatttacagg 351721 taggcaatat tagctgagct gttccgcgac taacatcgag ttgatatgaa acgcgtttca 351781 tagcctatga taggtttatc aaataattca ggagtgataa acactatgat ccaccagcat 351841 ccagaatctt ttccgaaaca ttttttgtgg ggctctgctt ctgcagcgta ccagattgaa 351901 ggcgcttgga atgaagatgg caaaggccct tctgtttggg atgtgtttac gaaaataccg 351961 ggcaaaacgt ttaaaggaac caatggcgag attgcggttg accattatca ccgatttaaa 352021 gaagatgtcg ctctgatggc tgagatgggg ttaaaagcat atcgattttc cgtcagctgg 352081 ccacgggttt ttccaaaagg aaaaggagag atcaatgaag caggtctagc gttttacgat 352141 agtctgattg atgaattgct ttctcatcac atcgagccgg ttctgacttt atatcactgg 352201 gatttgcctc aagcgcttat ggacgaatac ggcgggtttg aatccagaaa catcatagag 352261 gattttaatc actactgtat tactctttat aaacgttttg gagacagggt gaaatattgg 352321 gttacgttaa acgaacagaa ctacaatttt aatcacggat ttattacagc catgcatccg 352381 cctggagtga aagacagaaa acgattttac gaagcaaacc atattgcgtt tctggctaat 352441 gcaaaagcca tcgaatcatt tagagaatat gtgcctgaag gcaaaatagg tcctagcttt 352501 gcttattctc cggcttaccc tttatcaagt catccagagg atatactggc atttgaaaac 352561 gccgaagaat ttacgaacaa ttggtggctt gacatgtatt gctggggaac ctacccgcaa 352621 attccattcc gctgcttgga aaaacaggga tgggcgccga caattgaagc aggagatatg 352681 gacctgctcg ccaaagggaa gcctgatttt gtaggtgtca attattatca gacgatcacc 352741 tatgaacgaa atccgcttga tggtgtgtca gaagggaaaa tgaatacgac aggccaaaag 352801 ggaaccaatc aggagacggg gatacccgga gtgttcaaaa cgaaaaaaaa tccgcatctg 352861 acaacgagca actgggattg gacaattgac ccaattgggc tgcgtatcgg tcttcgccga 352921 attacaagcc gctatcagct tccagtgttt ataacagaga acggtttggg tgaatttgat 352981 aaagttgagg acggcactgt acaggatgat tatcgaattg attatttgcg ttcgcatctt 353041 gagcaatgca gacaagccat cagtgacggt gtcgatttaa tcggctattg cagctggtcg 353101 tttactgatc tgttaagctg gctgaacggc taccaaaaaa gatacggatt tgtatatgtc 353161 aatcgtgatg aagaaagcac atccgattta aaacgcttga agaaaaaaag cttttattgg 353221 tatcaagatg tcatcaagac aaacggagaa agtttataaa gagtccctga gagttattct 353281 ctcaggggtt tttcattaca cagaaacagc atcaataata taagtgtcgg cgtgcaaatc 353341 tgacatttca gccggcacag tccagcatgt caattgatag tctcctttag gcagatcaaa 353401 ggacagtctt ttagacatga tgctttcaat atgaattccg ttttctgtga catgaaaagg 353461 aacagtcact tttttttcgt aggagtttac tgtttctgaa ctgttcaggc gaaaaagaat 353521 aaaggccttt gtatttcgct gtgcctcaaa ggaaatggct ccgtctgccg cagcatatcc 353581 tttttcaatc gcttcgtcag tccaatccat tacaggaggt gtagaatcct tttgaaatac 353641 agtaaattga tgatatgaaa tcgaaagttc ttgcggcttc catgatttga tcaatgtgct 353701 gttcctcctc tatgtactgt ttactgaatt gtgaataaaa cctttgtgcc gtctgggtaa 353761 tcggtaagcc gatgcccgac ccaagagcct gctccgcggt tgtcagcggg agaaatgtat 353821 tctacagaag ctccctcacc gccttctttg cacatggcca ttggccattc atctctgtca 353881 tacccctttt tggaaggtac gtcctttaat gattgctcgc ggcgttcttc agctccgtct 353941 ctgtcaatag tgcacacctc tgagtgcccc tcatttatcg catccttaat atgcttggca 354001 gtttcgggat accggtcaga tgggaaggcc attgtttcat catattcttt cgtttgagac 354061 gttttttgat cagctgagaa aaagtctcct tttatcaggc cgacagctgc agctgctatg 354121 atgacgatga cgagaagtat cgtttttatg atgtccgtcg tgatgttcac ctcccgcttt 354181 taaaactgac acaagagtaa tccagaaagc atttggtgta aaggtttaaa ttttatgttt 354241 tacgatcagt ttattgcaga aatcgtaatt ttagcagatc gaaatatttg ttttcagcaa 354301 aatacgattg ccaatttaca ataatgatag taagtcatca gccgttttcg gcttgattaa 354361 tcattttaaa ttggcttatg ataccggtaa gctcctcagc taattgagaa agtgtttcag 354421 aagctgcggt aatctcctcc attgcagcaa attgctcctc tgttaatgca gccgcttgcc 354481 gggtattttt agtagattct ttaatgtcgg ccgtattggc tgcaaaggaa tcatttattt 354541 gatgtgcact ggctgaaatg tttgttacag atgctgataa atcactaatc tcggcgctga 354601 tttcacctgt tgcagctgca atttccttaa atgcatctct ggtgcgctgg atcatggtga 354661 ctccttctgc agcttctgtt ttcacatgct caacagatct tgcagaccgg ttcatatcct 354721 tttgtatttc tatgatcagt tttgaaatct gccccgcaga ctgttgagac tcttctgcta 354781 atttccgtac ttcatcagca acaacagcaa agccttttcc ttgttcaccg gctctggcag 354841 cttcaatcgc tgcattcagc gcaagcaggt ttgtctgatc agcaatttgg gtgatgaccg 354901 ataaaatttg ctcaatttgt ttagagcggc cgtctaactg gtgtatgatt tctccgcttt 354961 tctgaattga ctggtgaatc gcatccattt gcgcctgtac atttgcaatt tccttttgtc 355021 caatgtctgc ttttgattga gcgagctgcc ctttgtcagc gatagcggca gtatttgcag 355081 aaatatcccg gatgtctgct gaagcttgtt ttaatgagct ttcactattt tcaattcggg 355141 tgatctgatc ttgggctcca tttgcaatct gctgtacagc ttctgtgatt ttttctgaag 355201 cttgatttgt ttcctctgct ccggctgaga gctgctgaga ggctgacgca agctgaaggg 355261 ctgattgttg tacggtttgt atggtatcgt tcagcttcat tctcatctta ttataataga 355321 cgcttagttc tgaaagctcg tcaccggttt tgtctgacac ctctattgtc atatctccgt 355381 ttccggcact ttcaaaggcg ctttttaaag cgttcagccg cttgttgatt tttctggtga 355441 aaaccaagac aaggatgact gataccataa tgacgataac aagaacgata gcgaattgag 355501 tgaaaagtga ttgtgtaagt gatgctaaaa tactttgatt agctccggta tacagcatgc 355561 cgatgatgtt cccattttga tcttttaacg gcatgtatgc agtctgataa gaagaacctg 355621 ctacatctgc ttgtccgtaa aaacgctttc ctttctttaa aacagcggca ataacttcag 355681 aagaagcctg ggtgccgacg gctctttcgc catttttcat gacattggtt gcaacacgag 355741 tatcgccttg gaaaatggta atggtatcac ctgtcttttc accaagcaga tcaacaatat 355801 cttcatttcc attgatttgt gtttgccctt tatagagctt attgtttttc acctgccagt 355861 cgcctgacat gacatcatca atataagtgc tgcttaaagc gagatcacct ttcgcttttt 355921 cagttgccat ttgtttcatg ctttctgtaa tttccttaag catcacagtg ccaactgatg 355981 ccgaaaacaa aagaatcacc acgaaaacga ggcaaagaat tttagttcct agcttcatct 356041 taaatcgttt tatcaacata attcctccct ttacgatttg caggtcatat tacttatcgg 356101 gtttttgggt ttaaagtttt attttagaaa aaataaaacc ggcctgatct tcaggccggt 356161 tgtgtgatgc tattcaaggt ttgcgtggtg agtgaacata gtttcagaat cgagaccttt 356221 tttctccatg agttttaaaa tcactgcatc atagaagagc agcaaagttt gttcaaataa 356281 tgatcccatt ggctgaatgg ttttatagct tccgttagac tggtctttag gggaaccagg 356341 cattctgatg atgaggtccg cttgttttcc gatgcttgat tccggattga tggttaaagc 356401 ggcaacaatt ccgtgtaagc tttttgcttt tgctgcggta tgaatcaagc tctttgtctc 356461 gcctgatcct gagccgataa taactagatc tccttcggcg agcggcggag tgagaatctc 356521 acctactata tgggcgttga agcccatgtg catcagtctc atcgcgaagg attttgccat 356581 caggccagac cgccccgcac ccgcggtgaa aatttggtgg gatgaaagaa tgtgatcggc 356641 aagctggtca gcttcttcat tagaaatata agctgctgaa ttgtgtaact cattgagaat 356701 ttccgctacg tattcagtcg ttttcatcgg agttatcctt ggacaatcag ctgcttcatt 356761 tttgaagctg tttccgcctt atcagctgcg cttgtaattc cgcccccgac aatgacaagg 356821 tcaggctttt gctggatcac ttctggcagt gtatcaagtt tgatgccgcc cgcgattgcg 356881 gtttttgcgt tttttacggt atttttgatt gtcgttaatt cttcgaaaga gtttttgccc 356941 tctgcttgaa gatcatagcc agtgtggacg cagatgtagt caacaccgag tgcgtcaatt 357001 tctttcgcac gggattcgat atctttcacg ttaatcatgt ccactaagat tttcttcttt 357061 tgttttttgg cttcttctac tgcgccttta atcgttgcat cgtctgtagc ccctaaaacg 357121 gtgatgatgt cagcgcctgc ttccgacgct ttcataattt cgtagcctcc ggcatccatg 357181 attttcaggt ctgcaagaac cttcaattga ggaaatgctt cttttatttc tttaacggct 357241 cttaggcctt cattgatgac gaccggtgtt ccgatttcaa ctacgtcgat gtattgttct 357301 acctctttga caagctcaat ggcttccggg atgttgacga ggtctaatgc aagctgtaat 357361 tccattgttg atccactccc tttttcgaat tattgttcat tctataggtt ccttcttttg 357421 ttgagaagta ggcactttga agtcaacaag ttacttggag gatactgtga ggagagacaa 357481 tcagatttct ttcgcttgat tttatgagtg agtataatga aaaaagagtc tgcaaaaaag 357541 taagtaagtg atgatacgta tctaacatac aaaaaggtta ctaagggggg ggattctatt 357601 gagccggatg gacgacaaaa ggtttaattg tgagaaggaa ttaacgcttg cagtgattgg 357661 cggtaaatgg aaaatgctca ttttatggca tttaggaaaa gaaggcacaa aacggttcaa 357721 tgaattaaaa acattgattc ctgatattac gcagaagatc ctcgtgaatc agctgagaga 357781 gcttgagcag gatatgattg ttcacaggga agtgtatcca gttgtcccgc cgaaggttga 357841 atattctctg accccgcacg gagaaagcct catgcctatt cttgaagcca tgtatgagtg 357901 ggggaaaggc tatatggaat tgattgatat cgacaaaaat gtcatgaaag aatcgttgta 357961 agacgctctt cgcaagggtg tctttttttg cctttttttc ggtttttgcg cggtacacat 358021 agtcatgtaa agattgtaaa ttgcattcag caataaaaaa agattgaacg cagcagtttg 358081 gtttaaaaat ttttattttt ctgtaaataa tgtttagtgg aaatgattgc ggcatcccgc 358141 aaaaaatatt gctgtaaata aactggaatc tttcggcatc ccgcatgaaa cttttcaccc 358201 atttttcggt gataaaaaca tttttttcat ttaaactgaa cggtagaaag ataaaaaata 358261 ttgaaaacaa tgaataaata gccaaaattg gtttcttatt agggtggggt cttgcggtct 358321 ttatccgctt atgttaaacg ccgcaatgct gactgacggc agcctgcttt aatagcggcc 358381 atctgttttt tgattggaag cactgctttt taagtgtagt actttgggct atttcggctg 358441 ttagttcata agaattaaaa gctgatatgg ataagaaaga gaaaatgcgt tgcacatgtt 358501 cactgcttat aaagattagg ggaggtatga caatatggaa ataacttttt accctttaac 358561 ggatgcacaa aaacgaattt ggtacacaga aaaattttat cctcacacga gcatttcaaa 358621 tcttgcgggg attggtaagc tggtttcagc tgatgcgatt gattatgtgc ttgttgagca 358681 ggcgattcaa gagtttattc gcagaaatga cgccatgcgc cttcggttgc ggctagatga 358741 aaacggggag cctgttcaat atattagcga gtatcggcct gttgatataa aacatactga 358801 cactactgaa gatccgaatg cgatagagtt tatttcacaa tggagccggg aggaaacgaa 358861 gaaacctttg ccgctatacg attgtgattt gttccgtttt tccttgttca ccataaagga 358921 aaatgaagtg tggttttacg caaatgttca tcacgtgatt tctgatggta tctccatgaa 358981 tattctcggg aatgcgatca tgcacattta tttagaatta gccagcggct cagagacaaa 359041 agaaggaatc tcgcattcat ttatcgatca tgttttatct gaacaggaat atgctcaatc 359101 gaagcggttt gaaaaggaca aggcgttttg gaacaaacaa tttgaatcgg tgcctgaact 359161 tgtttccttg aaacggaatg catccgcagg gggaagttta gatgctgaga ggttctctaa 359221 agatgtgcct gaagcgcttc atcagcagat tctgtcgttt tgtgaggcga ataaagtcag 359281 tgttctttcg gtatttcaat cgctgctcgc cgcctatttg tacagggtca gcggccagaa 359341 tgatgttgtg acgggaacat ttatgggcaa ccggacaaat gcgaaagaga agcagatgct 359401 tggcatgttt gtttctacgg ttccgcttcg gacaaacatt gacggcgggc aggcgttttc 359461 agaatttgtc aaagaccgga tgaaggatct gatgaagaca cttcgccacc aaaagtatcc 359521 gtataatctc ctaatcaacg atttgcgtga aacaaagagc tctctgacca agctgttcac 359581 ggtttctctt gaatatcaag tgatgcagtg gcagaaagaa gaggatcttg cctttttgac 359641 tgagccgatt ttcagcggca gcggattaaa tgatgtctca attcatgtaa aggatcgatg 359701 ggatactggg aaactcacca tagattttga ttaccgcact gatttatttt cacgtgaaga 359761 aatcaacatg atttgtgagc gcatgattac catgctggag aacgcgttaa cgcatccaga 359821 acatacaatt gatgaattaa cactgatttc tgatgcggag aaagagaagc tgcttgcgag 359881 ggccggcggt aaatctgtga gctaccgtaa ggacatgacg ataccagagc tgttccaaga 359941 aaaggctgaa ctgctttctg atcatccagc ggttgtattt gaagatcgca cattgtccta 360001 tcgaacgtta catgagcaat ctgcacgcat cgccaatgtg ctgaaacaga aaggggttgg 360061 cccggacagt cctgtcgcgg ttttgattga acgctctgaa cggatgatta cagctatcat 360121 gggaatttta aaagccggcg gagcctatgt gccgattgat ccgggttttc ctgctgagcg 360181 cattcaatat attttggagg actgcggggc ggatttcatc ctgactgaat cgaaggttgc 360241 ggcgcctgaa gccgatgctg agctgattga cttagatcag gcgattgagg aaggtgcaga 360301 agaaagcctg aatgcagatg tgaacgctcg gaaccttgcc tacattattt acacatcggg 360361 aacaaccgga cgcccgaaag gcgttatgat cgagcatcgc caggttcatc atttggttga 360421 atctctgcag cagacgattt atcaaagcgg cagccaaacc ctgcggatgg cattgcttgc 360481 gccgttccac tttgatgcgt cagtgaagca gatcttcgcg tcgcttcttt tgggccaaac 360541 cctttatatc gtaccgaaga aaacagtgac gaacggggcc gcccttactg catattatcg 360601 gaagaacagc attgaggcga cggacggaac accggctcat ttgcaaatgc tggcagcagc 360661 aggcgatttt gaaggcctaa aactgaagca catgctgatc ggaggagaag gcctgtcatc 360721 tgttgttgcg gacaagctgc tgaagctgtt taaagaagcc ggcacagcgc cgcgtttgac 360781 taatgtgtac gggccgactg aaacgtgcgt tgacgcgtct gttcatccgg ttatccctga 360841 gaatgcagtt caatcagcgt atgtgccgat cgggaaagcg ctggggaata accgcttata 360901 tattttggat caaaaaggcc ggctgcagcc tgaaggcgtg gcgggtgagc tttatatcgc 360961 gggagacggt gtgggccgag gctatttaca tttgcctgaa ttaacggaag agaagttttt 361021 acaagatcca ttcgtgccgg gcgatcgcat gtaccggacc ggggacgtgg tgcgctggct 361081 tccagatgga acaatcgaat atttaggcag agaggatgac caggtcaaag tccgcggata 361141 ccggattgag cttggggaaa ttgaagccgt gattcagcag gcgccagacg ttgcaaaagc 361201 cgttgttttg gcacgccctg acgaacaggg aaatcttgag gtttgcgcat atgttgtgca 361261 gaagcctgga agcgaatttg cgccagccgg tttgagggag catgcggcca gacagcttcc 361321 tgactatatg gtgccggctt actttacaga agtgacagaa attccgctta caccaagcgg 361381 caaagtcgac cgccgcaagc tgtttgcact agaggtgaag gctgtcagcg gcactgccta 361441 tacagcgccg cgaaatgaga ctgaaaaagc aatcgcagcc atttggcagg acgtgctgaa 361501 cgttgagaag gcggggatct ttgacaattt ctttgaaact ggcggacatt cattaaaagc 361561 catgaccctt ttaacaaaga ttcataagga aacaggcatt gagattccgc ttcaattttt 361621 gtttgagcat ccgacgatta cggctcttgc agaggaagct gatcacagag aaagcaaagc 361681 ttttgcggtg attgaacctg ctgaaaaaca ggagcattac ccgctttcat tggcacagca 361741 gcgaacatat atcgtcagcc agttcgagga tgcgggagtc ggctataaca tgccagcagc 361801 agcaattctg gaagggcctt tagatattca aaagctggag cgcgcatttc agggattaat 361861 ccgacgccac gagtcattga gaacatcatt tgttcttgaa aacagcacgc cgagacagaa 361921 aattcacgat agcgttgatt tcaacatcga aatgattgaa agaggcggcc gctcagatga 361981 ggcaattatg gcttcattcg ttcggacatt tgatttggcg aaagctccgc tgttcagaat 362041 cggtttgctg gggcttgaag agaaccgtca tatgctgctg tttgacatgc accatttgat 362101 ttctgacggt gtatccattg gcattatgct ggaggagtta gcacgcattt ataaaggcga 362161 acagcttcct gatcttcgtc tccagtataa ggactacgct gtatggcaaa gcagacaggc 362221 tgctgaaggg tacaagaagg accaggctta ttggaaggaa gtctttgcag gcgagctccc 362281 ggtgcttcag cttctgtccg attacccaag accacctgtt caaagctttg aaggggatcg 362341 ggtgtcaatc aagctggatg cgggggtaaa ggatcgcctc aatcgtttgg ctgaacaaaa 362401 cggcgccact ttatatatgg tgatgctttc cgcttactat acgcttttgt caaagtatac 362461 ggggcaggat gacatcattg tcgggacacc gtcagcgggc agaaatcact ccgatacaga 362521 gggcattatc gggatgttcg tcaatacgct tgcgattcgc agtgaggtga agcagaatga 362581 gacgtttacc caattgatct cgcgtgtccg caaacgggtg ctggatgcct tttctcatca 362641 ggactatccg tttgagtggc ttgttgaaga tttgaacatc ccgcgtgatg ttagcaggca 362701 tccgctgttt gacacgatgt tcagccttca aaacgcgaca gagggcattc cggctgtcgg 362761 cgatctttcc ttgtctgttc aagagaccaa tttcaagatt gccaaatttg atttgacggt 362821 gcaggcgaga gaaaccgatg aaggcattga gattgatgtg gattacagca caaagctgtt 362881 taaacaaagc acggcagaca ggctgcttac gcattttgcg cgtttgcttg aagatgctgc 362941 ggctgatcca gagaagccga tttctgagta taagcttctt tctgaagagg aggctgcttc 363001 gcaaattcag cagtttaacc cgggcagaac accttatccg aaagataaaa caattgttca 363061 gctgtttgag gagcaagcgg cgaatacgcc agaccacact gcgcttcaat atgaaggcga 363121 atcactcact tatcgtgaac tgaatgaacg ggccaatcgt ttagcccgcg gcattctttc 363181 tcttggagct ggcgaaggca gaactgcggc tgtcttatgc gagcggtcaa tggatatgat 363241 tgtgtcgatc ttggcagtat taaaatcagg ttcggcttat gttccgatcg atccggaaca 363301 tccgattcag cggatgcagc atttcttccg tgacagcgga gcaaaggtgc ttctcactca 363361 gaggaaatta aaggctttgg cggaagaagc ggaatttaag ggcgttatcg tgctagccga 363421 tgaggaagaa agctatcatg ccgatgcgcg aaatctcgca ctgcctcttg attctgcagc 363481 aatggccaac ctgacgtata cttccggaac gactggaaca cctaagggga atatcgtgac 363541 acatgccaat attctccgca cggtgaagga aacgaattat ctcagcatta cagaacagga 363601 tacgattctc ggtctttcca attacgtgtt tgacgcgttt atgttcgata tgttcggctc 363661 tttgttaaac ggagccaagc tggtgctgat accgaaggaa accgttttgg acatggctcg 363721 cctgtcccgc gtcattgaac gggagaacat cagcattctc atgattacaa ccgctttgtt 363781 ccacttgctt gtggacttga atccggcatg cttgtcaacg cttcgcaaga ttatgtttgg 363841 cggggaacgg gcttcggttg agcatgtcag aaaagctttg caaacggttg gaaagggcaa 363901 gctccttcat atgtatggac cgtctgaaag cacggttttc gcgacgtatc atccggttga 363961 tgaattggag gagcacacgc tgtctgttcc gattggaaaa ccggtcagca atacggaagt 364021 atacattctt gaccgtacgg gacacgtgca gcctgccggg attgccggag agctttgcgt 364081 cagcggcgaa ggactcgtga aaggctatta caaccgtcca gaactgactg aggagaaatt 364141 tgttccccat ccgtttacat ccggcgaacg catgtataaa acgggagacc ttgcgagatg 364201 gctgccgaat ggcgacatcg aatttatcgg gcgaatcgac catcaggtga agattcgcgg 364261 acagcgcatc gagcttggag aaatcgaaca tcagctgcaa acccatgatc gtgttcagga 364321 aagtgttgtg cttgccgttg atcaaggagc gggagataaa ctgttgtgtg cttactatgt 364381 cggagaagga gacatctcat cacaagagat gagagagcat gctgcgaagg acttgccggc 364441 atatatggtt cctgcggtgt ttatccaaat ggacgagctg ccgctgacag ggaacggaaa 364501 aattgaccgg agagcgctgc cgattcctga tgccaacgtt tcaagaggtg tttcatatgt 364561 tgcgccacgc aatggaacgg aacaaaaagt cgcggacatt tgggcacagg tacttcaggc 364621 agaacaagtc ggcgcttatg accacttctt tgacattggc ggacattcat tagcaggcat 364681 gaagatgctt gccttggttc atcaggaact gggcgttgag ctgtcactca aggatctctt 364741 ccagtcaccg acggttgagg gcttggcaca ggtgattgcc tctgctgaaa aagggacagc 364801 cgcaagtatc agcccggcag agaaacaaga tacgtatcct gtttcttcac cgcaaaaacg 364861 gatgtacgtg cttcagcagc ttgaggatgc gcaaacgagc tataacatgc cggcggttct 364921 gcgcctgaca ggtgagcttg atgttgaaag gcttaacagc gtcatgcagc agttaatgca 364981 gcgtcatgaa gccttgagaa ccacgtttga aataaaagat ggagaaacgg tgcagcggat 365041 ctgggaagag gctgagtgcg agatagccta tttcgaagcc ccggaagaag agacagagcg 365101 gatcgtttct gagtttatta agcctttcaa aatcgaccaa cttccactgt tcagaatagg 365161 gcttatcaag cattcagaca ctgagcatgt gctgctgttc gatatgcatc atattatttc 365221 tgatggtgca tctgtcggtg tgctgattga ggagctttca aagctgtacg acggagaaac 365281 ccttgagccg ctccgtattc aatataagga ttatgccgtg tggcagcagc agttcattca 365341 gtctgagctt tacaagaagc aagaagagca ttggctgaag gagctggacg gagagctgcc 365401 ggtgctgacg cttccgactg attacagtcg gcctgccgtt caaacatttg agggagaccg 365461 cattgcattt tcattagaag caggcaaagc tgatgctctg cgcaggcttg caaaagaaac 365521 ggattccacg ctttacatgg tgcttctggc ttcatacagt gcgtttttat caaaaattag 365581 cgggcaagac gatatcatcg tcggttcacc tgtggccgga cgatctcaag cggacgtcag 365641 ccgcgtcatc ggaatgttcg tcaatacatt ggcgctgcgc acgtatccga agggtgaaaa 365701 gacgtttgct gactatctta acgaagtgaa agaaacggca ctcagcgctt ttgatgcgca 365761 ggattaccca cttgaggatt tgatcggaaa tgttcaggtt cagcgtgaca caagcagaaa 365821 tccgttattc gatgcagttt tttcaatgca aaatgcgaat ataaaggatt taacaatgaa 365881 agggattcag cttgagccgc atccgtttga acggaaaaca gccaagtttg acctcacgct 365941 gacggctgac gaaaccgacg gagggcttac attcgtactc gaatacaata cagctctgtt 366001 taagcaggaa acgattgaac gatggaagca atattggatg gagcttttag atgcagttac 366061 tgggaacccg aaccagccgc tttccagcct gtcactggtc accgagacag aaaagcaagc 366121 gcttcttgag gcatggaagg gcaaagcgct gcctgtgccg acagacaaaa cggttcatca 366181 gctattcgaa gagactgccc agcgccacaa agaccgcccg gctgtcacat acaacggcca 366241 gtcttggacg tacggcgagc tgaatgcgaa ggcaaaccgt ctcgcgcgga ttctgatgga 366301 ctgcggcatc agcccggatg accgcgtcgg cgttctcacg aagccgtcgc ttgaaatgtc 366361 cgccgcggtg ctcggcgtct tgaaagccgg agcggcgttt gtgccgattg atcctgacta 366421 tccggatcag cggattgagt atattttaca ggacagcggc gcgaagcttc tcttgaaaca 366481 ggaaggcatt tcagtgccgg acagctatac gggagatgtc attcttctcg acggaagccg 366541 cacgattcta agcctgccgc ttgatgaaaa cgacgaggaa aatccagaaa ccgctgtaac 366601 cgcggagaac ttggcgtaca tgatttacac gtctggaacg accggacagc cgaagggtgt 366661 catggtcgag caccatgcgc ttgtgaacct gtgcttctgg caccacgacg cgttcagcat 366721 gacagcggag gaccgcagtg cgaagtacgc gggctttggg ttcgacgctt ccatttggga 366781 gatgttcccg acctggacga tcggtgccga acttcacgtc attgaggaag cgatccgcct 366841 cgatatcgtc cgcctgaacg attattttga aacgaacggc gtaacgatca cgttcctgcc 366901 gacacagctt gcggaacagt tcatggagct tgagaacaca tcacttcgcg tattgcttac 366961 tggaggagac aagctgaagc gcgcagtgaa aaagccgtac acactcgtca ataactacgg 367021 gccgacagag aatacggtcg ttgccacaag cgcagaaatc catccggagg aaggctcgct 367081 ttccatcgga agggccattg ccaatacgag agtatacatt ctcggcgagg gcaatcaggt 367141 gcagccggaa ggcgtagccg gagagctttg cgtggcgggg cgcggactgg cacgcggcta 367201 tctgaatcga gaagacgaaa ccgcgaagcg gtttgtcgct gatccgtttg tgccgggtga 367261 gcgcatgtac cgcaccggcg atttggtgaa atggacgggc ggcggcatcg aatacatcgg 367321 ccggatcgac cagcaggtca aggtccgcgg ctaccggatc gagctctcag aaattgaagt 367381 ccagctcgcc cagctttctg aggtgcagga tgcggcggtg acagctgtca aagataaagg 367441 cggcaacaca gcgatcgcgg cgtatgtcac accggaatca gctgacatag aagcactgaa 367501 atcagcactg aaggaaaccc tgccggatta catgatcccg gcgttctggg tgacgctgaa 367561 cgagcttccg gttacggcaa acggcaaagt ggaccgcaaa gccttgcctg agccggacat 367621 cgaagcggga agcggagaat acaaagcgcc gacgaccgac atggaagagc tgcttgccgg 367681 catctggcag gacgtgcttg gaatgtctga agtcggtgtc accgacaatt tcttctcgct 367741 tggcggagat tccatcaaag gaattcaaat ggcgagccgc ttgaaccagc acggctggaa 367801 gctggaaatg aaagatctct tccagcaccc gacgatcgaa gagctcaccc agtacgtaga 367861 gcgtgccgaa ggcaaacagg cagaccaagg cccggtggag ggcgaagtca tcctgacgcc 367921 gatccagcgc tggttctttg aaaagaactt cacgaacaag caccactgga accaatctgt 367981 gatgcttcac gccaagaagg gctttgatcc tgaacgggtg gagaaaacat tgcaggcgct 368041 gatcgagcat catgacgcgc tccgcatggt ctatcgtgag ggacaggaag acgtcattca 368101 atacaacaga ggtcttgaag ctgcttcagc tcaattggag gtcatccaga ttgagggcca 368161 agctgcagat tacgaagacc gaatagagag agaagcggag cgtttgcaaa gcagcatcga 368221 cttgcaggaa ggcggcttgt taaaagcagg cttgttccaa gcggaagacg gagatcactt 368281 gcttcttgcc attcaccact tagtggttga cggcgtgtcg tggcggattt tactggagga 368341 tttcgccgcg gtatatacac agcttgagca aggcaatgaa ccggttctcc cgcagaaaac 368401 acattcattt gcagagtatg cagagagatt gcaagacttc gcgaactcca aagccttttt 368461 gaaagaaaaa gagtattgga gacagcttga agaacaagct gttgcggcaa agcttccgaa 368521 agaccgcgaa tctggtgatc agcgaatgaa acatacaaag acaattgaat tctcgctgac 368581 tgctgaagag acagaacagc tcaccacaaa ggtgcatgag gcatatcaca cagaaatgaa 368641 tgatattttg ctgacggcat tcggattggc aatgaaggag tggacgggtc aagatcgagt 368701 aagtgttcat ttagaggggc atggacgtga agaaatcata gaagacctga ccatttctcg 368761 cacagtcggc tggtttacaa gtatgtaccc aatggtgctc gatatgaagc atgcggatga 368821 tctgggctac cagctgaagc aaatgaaaga agatatcaga catgtgccga ataagggagt 368881 cggatacggc attctgcgct atctgacggc accggaacat aaagaagatg tggcgttctc 368941 gattcagccg gatgtcagct tcaactattt aggtcagttt gacgaaatgt cggatgcagg 369001 tttgtttacg agatcagagc tgccatcagg acagtcatta agccctgaaa cagaaaaacc 369061 gaatgcgctg gatgttgtcg gatatatcga aaacggaaaa ctgacgatgt cactggccta 369121 tcattctctt gaatttcatg aaaaaacagt acaaacattc agtgacagct ttaaagcgca 369181 tcttctcaga atcattgaac attgcctatc tcaagatggt acggaactga ccccgagtga 369241 tcttggtgac gacgatttga cgctggatga gctggataaa ttaatggaaa ttttctaata 369301 gaggtggcat atgagcaaaa aatcgattca aaaggtgtac gcactgacac caatgcagga 369361 gggaatgctg tatcatgcga tgcttgatcc gcattcttcc tcgtacttca cacaattaga 369421 gcttgggatt cacggcgctt ttgatcttga aatctttgag aaaagcgtca atgaactgat 369481 tcggtcatac gatattctcc gtacggtatt tgtgcatcag cagctgcaaa aaccgcgtca 369541 ggtcgtgtta gcggaacgca aaacaaaagt gcattatgag gatatcagtc atgcagacga 369601 aaaccgccag aaagagcaca ttgagcgtta caaacaagac gttcagcgcc aaggctttaa 369661 cctggcaaaa gacatattgt tcaaggtagc ggttttccgc cttgctgcag atcagctgta 369721 tcttgtctgg agcaatcatc atattatgat ggacggctgg agcatgggcg tcctcatgaa 369781 aagcctgttc caaaactatg aagcgctcag agcaggcagg acaccggcaa acggtcaggg 369841 caagccttat tccgattaca tcaagtggct tggaaaacag gacaatgaag aagcggagag 369901 ctactggagc gagcgcttgg cgggttttga acagccaagc gtgctcccgg gccgcctgcc 369961 tgtgaaaaaa gacgaatacg tcaataaaga atattcattt acatgggacg aaacactggt 370021 tgcccgtatt cagcaaaccg caaatctcca tcaagtgaca gggcctaacc tatttcaggc 370081 cgtttggggc attgttctca gcaaatacaa ctttacggat gatgtgatct tcggaacggt 370141 cgtctcggga cgaccgtctg aaatcaacgg aatcgaaacg atggcggggc tgtttatcaa 370201 caccattcca gtgcgggtga aagttgaacg agatgctgca ttcgctgata ttttcacagc 370261 tgttcagcag catgcagtag aggcagagcg ttacgattac gtgccgctct atgagattca 370321 aaaacgctca gctcttgatg gcaatctctt aaaccatctg gtcgcgtttg aaaattatcc 370381 gcttgatcaa gagcttgaaa acggcagcat ggaagaccgc ctcgggtttt cgattaaggt 370441 agaaagcgca tttgaacaaa cgagcttcga tttcaacctg attgtgtatc cgggcaaaac 370501 gtggaccgtc aaaattaaat ataacggagc cgcctttgat tccgctttta tcgaacggac 370561 agcggagcac cttacccgca tgatggaagc agctgtcgat cagccggccg cttttgtgcg 370621 tgagtacggg cttgtgggag acgaagagca gcggcaaatt gtcgaggtgt ttaacagcac 370681 gaaagccgaa ctccctgaag gaatggctgt tcaccaagtg tttgaagagc aagcgaaacg 370741 gacgccggcg agcaccgccg tcgtatatga aggaaccaag ctgacgtacc gcgagctgaa 370801 tgcagcggct aaccgtctgg cgagaaagct tgtcgaacat gggcttcaaa aaggggaaac 370861 agcagcgatt atgaacgacc gctcagtaga aaccgttgtc ggcatgctgg ctgttttaaa 370921 agcaggcgcc gcatatgtgc cgcttgatcc agcgcttcct ggggatcgtc ttcgtttcat 370981 ggcagaggac agctccgttc gaatggtttt gatcggaaat tcttatacag ggcaggcaca 371041 tcagctgcaa gtgccggttc ttacactgga cataggcttt gaagagagtg aagcggctga 371101 caatctcaac ctgccatccg ccccgtctga tttggcgtac atcatgtaca catccggttc 371161 aacgggcaaa ccgaaaggcg tcatgatcga acataaaagc attctgcgcc tcgtcaaaaa 371221 tgccgggtac gttcctgtta ctgaagaaga ccgcatggcg caaacgggag ctgtcagctt 371281 tgatgccgga acgtttgagg tattcggcgc actgctgaat ggcgcagcac tttatccggt 371341 caaaaaagag acactgcttg atgcgaaaca atttgctgca ttcctgcgtg agcaaagcat 371401 cacaactatg tggctgacat cacctttatt caaccagctt gctgcaaagg atgcgggtat 371461 gttcggcaca ctgcgccatt taatcatcgg cggagatgcc cttgtcccgc atattgtcag 371521 caaagtaaaa caggcatcgc cgtcgctttc attgtggaac ggatacggcc cgacagaaaa 371581 cacgacgttt tcaaccagtt ttctgatcga ccgcgagtat ggcggctcta tcccaatcgg 371641 gaagccgatc ggaaattcca ctgcctatat tatggatgag cagcaatgcc tgcagccaat 371701 cggcgcgcct ggtgagcttt gcgtaggcgg aatcggtgta gcgcgtgggt atgtcaatct 371761 ccctgagctg acggagaagc aatttctgga agacccgttc agaccgggtg agagaattta 371821 ccgcactggt gacttggcaa gatggctgcc ggacggcaat atcgaatttt taggcagaat 371881 cgacaaccaa gtgaaggtgc gcggcttccg aattgagctt ggcgaaattg aaacaaaact 371941 gaacatggct gagcatgtga cagaagccgc ggtgatcata cgcaagaaca aagcagacga 372001 aaatgaaatt tgcgcgtact tcacggcgga tcgtgaagtg gctgtgagtg agctgagaaa 372061 aacactgtct cagtctttgc ctgactatat ggtccctgcc cacctgattc aaatggacag 372121 cctgccgctc acgccaaacg ggaaaatcaa caaaaaggaa ctgcctgcac cgcaatcaga 372181 agccgtgcag ccggaatacg cagcaccaaa aacagagagt gaaaagaaat tagcggagat 372241 ctgggaagga atactcggcg tcaaagcagg cgttaccgat aacttcttta tgatcggcgg 372301 ccattctttg aaagcgatga tgatgacggc gaaaattcaa gagcattttc ataaggaagt 372361 tccgataaaa gtgctttttg aaaagccgac tattcaagaa ctggcactgt atttggaaga 372421 gaacgaaagc aaggaggagc agacgtttga accgatcagg caagcatctt atcagcagca 372481 ttatcctgta tccccggccc agcggagaat gtatatcctc aatcagcttg gacaagcaaa 372541 cacaagctac aacgtccccg ctgtacttct gctggaggga gaagtagata aagaccggct 372601 tgaaaacgcg attcagcaat taatcaaccg gcacgaaatc ctccgtacat cgtttgacat 372661 gatcgacgga gaggttgtgc aaaccgttca taaaaacata tcgttccagc tggaggctgc 372721 caagggacgg gaagaagacg cggaagagat aatcaaagca tttgttcagc cgtttgaatt 372781 aaaccgcgcg ccgctcgtcc gttcgaagct tgtccagctg gaagaaaaac gccacctgct 372841 gctcattgat atgcatcata ttattactga cggaagttca acaggcattc taatcggtga 372901 tcttgccaaa atatatcaag gcgcagatct ggaactgcca caaattcact ataaagatta 372961 cgcagtttgg cacaaagaac aaactaatta tcaaaaagat gaggaatact ggctcgatgt 373021 ctttaaaggc gaactgccaa tactggatct tcccgcggat ttcgagcggc cagctgaacg 373081 gagctttgcg ggagagcgcg tgatgtttgg gcttgataag caaatcacgg ctcaaatcaa 373141 atcgctcatg gcagaaacag atacgacaat gtacatgttt ttgctggcgg cgttcaatgt 373201 actcctttcc aagtacgcgt cacaggatga tatcattgtc ggctcgccga cagctggcag 373261 aacacatcct gatctgcaag gtgtgccggg tatgtttgtc aacacggtgg cactcagaac 373321 ggcaccagcg ggagataaaa ccttcgcgca attccttgaa gaggtcaaaa cagccagcct 373381 tcaagcattc gagcaccaga gctatccgct tgaggagctg attgaaaagc ttccgcttac 373441 aagggataca agcagaagtc cgctgttcag cgtgatgttc aacatgcaga atatggagat 373501 tccttcatta agattaggag atttgaagat ttcctcgtat tccatgcttc atcatgttgc 373561 gaaatttgat ctttccttgg aagcggtcga gcgtgaagag gatatcggcc taagctttga 373621 ctatgcgact gccttgttta aggacgagac gatccgccgc tggagccgcc actttgtcaa 373681 tatcatcaaa gcggccgcgg ctaatccgaa cgttcggctg tctgatgtag atctgctttc 373741 atctgcagaa acggctgctt tgctagaaga aagacatatg actcaaatta ccgaagcaac 373801 ctttgcagca ctttttgaaa aacaggccca gcaaacacct gaccattctg cggtgaaggc 373861 tggcggaaat ctgttgacct atcgcgagct tgatgaacag gcgaaccagc tggcgcatca 373921 tcttcgtgcc caaggggcag gaaatgaaga catcgtcgcg attgttatgg accggtcagc 373981 tgaagtcatg gtatccattc tcggtgtcat gaaggcgggg gcagctttcc ttccgattga 374041 tcctgataca cctgaagaac gaatccgtta ttcattagag gacagcggag caaaatttgc 374101 ggtcgtgaat gaaagaaaca tgacggctat tgggcaatat gaagggataa ttgtcagcct 374161 tgatgacggt aaatggagaa atgaaagcaa ggagcgccca tcatccattt ccgggtctcg 374221 caatcttgca tacgtcattt atacgtccgg tacgaccgga aagccaaagg gcgtgcagat 374281 tgagcatcgt aatctgacaa actatgtctc ttggtttagt gaagaggcgg gcctgacgga 374341 aaatgataag actgtattgc tttcatctta cgcatttgac cttggctata cgagcatgtt 374401 ccctgtactt ctgggcgggg gcgagctcca tatcgtccag aaggaaacct atacggcgcc 374461 ggatgaaata gcgcactata tcaaggagca tgggatcact tatatcaagc tgacaccgtc 374521 tctgttccat acaatagtga acaccgccag ttttgcaaaa gatgcgaact ttgaatcctt 374581 gcgcttgatc gtcttgggag gagaaaaaat catcccgact gatgttatcg ccttccgtaa 374641 gatgtatgga cataccgaat ttatcaatca ctacggcccg acagaagcaa cgatcggcgc 374701 catcgccggg cgggttgatc tgtatgagcc ggatgcattt gcgaaacgcc cgacaatcgg 374761 acgcccgatt gcgaatgccg gtgcgcttgt cttaaatgaa gcattgaagc ttgtgccgcc 374821 tggagcgagc ggacagctct atatcacggg acaggggctc gcgagagggt atctcaacag 374881 gcctcagctg acagccgaga gatttgtaga aaatccatat tcgccgggaa gcctcatgta 374941 caaaaccgga gatgtcgtac gaagactttc tgacggtacg cttgcattta tcggccgggc 375001 tgatgatcag gtgaaaatcc gaggctaccg cattgagccg aaagaaattg aaacggtcat 375061 gctcagcctc agcggaattc aagaagcggt tgtactagcg gtttccgagg gcggtcttca 375121 agagctttgc gcgtattata cgtcggatca agatattgaa aaagcagagc tccggtacca 375181 gctttcccta acactgccgt ctcatatgat tcctgctttc tttgtgcagg ttgacgcgat 375241 tccgctgacg gcaaacggaa aaaccgacag aaacgctctg ccgaagccta acgcggcaca 375301 atccggaggc aaggccttgg ccgcaccgga gacagcgctt gaagaaagtt tatgccgcat 375361 ttggcagaaa acgcttggca tagaagccat cggcattgat gacaattttt tcgatttagg 375421 cggccattca ttaaaaggga tgatgctgat tgccaacatt caggcggaat tggagaaaag 375481 cgtaccgctt aaagcactgt tcgagcagcc gacagttcgc cagctggcgg cttatatgga 375541 ggcgtctgct gtttcaggcg gccatcaagt actcaaaccg gctgacaagc aggatatgta 375601 tccattgtca tccgcacaga aacgaatgta cgtgctcaat cagcttgacc gccagacgat 375661 aagctacaac atgccatctg ttcttctaat ggaaggagag cttgatattt cgcgcctgcg 375721 cgactcactc aatcagcttg tgaaccgtca cgaatcattg cggacgtcat ttatggaagc 375781 taatggtgag cctgttcagc gcatcattga gaaggcggag gttgatcttc atgtgtttga 375841 agccaaagaa gacgaagcgg accaaaagat taaggaattt atccggccat tcgacttaaa 375901 cgacgcaccg ctcattcgcg cagctttgct tcgaatagaa gcgaaaaaac atttgctgct 375961 tttagatatg catcatatca tcgcagacgg cgtctcaaga ggcatctttg taaaagaatt 376021 ggcgctgctt tacaaaggag agcagcttcc ggagccgacg cttcattata aagatttcgc 376081 cgtttggcaa aatgaagctg agcaaaaaga acggatgaag gagcatgagg cgtactggat 376141 gtcagttctt tcaggcgagc tgccagagct tgatctcccg ctcgattatg cccgtccgcc 376201 tgtgcaaagc tttaaaggag atacgatccg tttccgtacg ggaagtgaga cggcaaaggc 376261 ggtagaaaaa ctgcttgccg aaaccggaac gaccttgcac atggtgctcc atgctgtttt 376321 ccacgtcttt ttaagcaaaa tttccggaca gcgggatatc gtcatcggct ccgttactgc 376381 cggccggacg aatgctgatg ttcaggacat gccgggaatg ttcgtcaata cacttgccct 376441 gagaatggaa gcgaaagaac agcaaacatt tgcggagctt ttggagctag caaagcagac 376501 gaacctgtca gcccttgagc atcaggagta tccgtttgaa gatctggtta atcagcttga 376561 tctccctcgg gatatgagcc gaaacccatt gtttaatgtg atggtgacga cagaaaaccc 376621 tgataaagaa cagcttacat tgcaaaatct gagcatttca ccttatgagg ctcatcaggg 376681 aacttctaag tttgatctga cactgggcgg atttactgat gaaaatggca ttggcttgca 376741 gctcgaatat gcgacagatc tgttcgcaaa agaaacagct gaaaaatgga gcgaatacgt 376801 tctgcggcta ctaaaggctg ttgcggataa cccgaaccag ccgctttcca gtctgttact 376861 ggtcaccgag acagaaaagc aagcgcttct tgaggcatgg aagggcaaag cgctgcctgt 376921 gccgacagac aaaacggttc atcagctatt cgaagagact gtccagcgcc acaaagaccg 376981 cccggctgtc acatacaacg gccaatcttg gacgtacggc gagctgaacg cgaaggcaaa 377041 ccgcctcgcc cggattctga tggactgcgg catcagcccg gatgaccgcg tcggcgttct 377101 cacgaagccg tcgcttgaaa tgtccgccgc ggtgctcggc gtcttgaaag ccggagcggc 377161 gtttgtgccg attgatcctg actacccgga tcagcggatt gagtatattt tacaggacag 377221 cggcgcgaag cttctcttga aacaggaagg catttcagtg ccggacagct atacgggaga 377281 tgtcattctt ctcgacggaa gccgcacgat tctaagcctg ccgcttgatg aaaacgacga 377341 gggaaatcca gaaaccgctg taaccgcgga gaacttggcg tacatgattt acacgtctgg 377401 aacgaccgga cagccgaagg gtgtcatggt cgagcaccat gcgcttgtga acctgtgctt 377461 ctggcaccac gacgcgttca gcatgacagc ggaggaccgc agtgcgaagt acgcgggctt 377521 cgggttcgac gcttccattt gggagatgtt cccgacctgg acgatcggcg ctgaacttca 377581 cgtcattgat gaagcgatcc gcctcgatat cgtccgcctg aacgattatt ttgaaacgaa 377641 cggcgtaacg atcacgttcc tgccgacaca gcttgcggaa cagttcatgg agcttgagaa 377701 cacatcactt cgcgtcctct tgaccggagg agacaagctg aagcgggcag tgaaaaagcc 377761 gtacacactc gtcaacaact acgggccgac agaaaatacg gtcgttgcca caagcgcaga 377821 aatccatccg gaggaaggct cgctttccat cggacgggcc attgccaata cgagagtata 377881 cattctcggc gagggcaatc aggtgcagcc ggaaggcgta gccggagagc tttgcgtggc 377941 ggggcgcgga ctggcacgag gctatctgaa tcgagaagac gaaaccgcga agcggtttgt 378001 cgctgatccg tttgtgccgg gtgaacgcat gtaccgcacc ggcgacttgg tgaagtgggt 378061 gaacggcggc atcgaataca tcggccggat cgaccagcag gtcaaggtcc gcggctaccg 378121 gatcgagctc tcagaaattg aagtccagct cgcccagctt tctgaggtgc aggatgcggc 378181 ggtgacagct gtcaaagata aaggcggcaa tacagcgatc gcggcgtatg tcacaccgga 378241 aacagctgac atagaagcac taaaatcaac actaaaggaa accctgccgg attacatgat 378301 cccggcgttc tgggtgacgc tgaacgagct tccggttacg gcaaacggca aagtcgaccg 378361 caaagccttg cctgagccgg acatcgaagc gggaagcgga gaatacaaag cgccgacgac 378421 cgacatggaa gagctgcttg ccggcatctg gcaggacgtg cttggaatgt ctgaagtcgg 378481 tgtcaccgac aatttcttct cgcttggcgg agattccatc aaaggaattc aaatggcgag 378541 ccgcttgaat cagcacggct ggaagctgga aatgaaagat ctcttccagc atccgacgat 378601 cgaagagctc acccagtacg tagagcgtgc cgaaggcaaa caggcagacc aaggcccggt 378661 ggagggcgaa gtcatcctga cgccgatcca gcgctggttc tttgaaaaga acttcacgaa 378721 caagcaccac tggaaccaat cggtgatgct tcacgccaaa aagggctttg atcctgaacg 378781 ggtggagaaa acattgcagg cgctgatcga gcatcatgac gcgctccgca tggtctaccg 378841 cgaggaaaac ggggacatcg ttcaggtgta taaaccgatc ggtgagagca aggtcagctt 378901 cgaaatcgtg gatctgtacg gctccgatga agagatgctg agaagccaga ttaagcttct 378961 cgcgaacaag ctgcaaagca gtctcgatct gcgaaacggg ccgcttttaa aggcggagca 379021 atatcgcaca gaagctgggg atcacctgct cattgctgta caccatctcg tggtcgacgg 379081 tgtgtcatgg cggattttgc ttgaagactt tgcttcaggc tacatgcagg ctgagaaaga 379141 agagagcctt gtcttcccgc aaaaaacaaa ctccttcaag gattgggcgg aagaactggc 379201 ggcattcagc caatcagcgc atcttttaca gcaggctgaa tactggtcgc aaattgccgc 379261 tgaacaggtt tctcctttac ctaaggattg tgaaacagag cagcggatcg tcaaggatac 379321 atcatctgtc ctatgtgaat taacggcaga agacactaag catcttttaa cagatgttca 379381 tcagccatat ggaactgaaa tcaacgatat tcttctcagc gcgctcggtt tgacaatgaa 379441 agaatggaca aagggggcca aaattggcat taaccttgag ggacacggcc gggaggacat 379501 tatcccgaat gtgaatatct ccagaacggt cggctggttt acggcacaat accctgttgt 379561 gctcgacata tctgacgcag atgcctcagc tgtgatcaaa acagtcaaag aaaacctgcg 379621 ccgcattccg gacaaaggtg ttggctacgg cattcttcgt tatttcacag aaacagcgga 379681 aacaaagggc ttcacaccgg agatcagctt caactatttg ggccaattcg acagtgaagt 379741 caaaaccgat ttctttgaac cgtccgcttt cgatatgggg cgccaagtaa gcggagaatc 379801 agaggcgctg tacgcattaa gcttcagcgg catgatcaga aacggccggt ttgtgctttc 379861 ctgctcctac aatgagaagg agtttgaaag agctacagtc gaggagcaaa tggaacggtt 379921 taaagaaaac ctcctgatgc taatccgcca ttgcacggaa aaagaagaca aggaattcac 379981 accaagcgac ttcagcgccg aagaccttga aatggacgag atgggagata tctttgacat 380041 gcttgaggag aatttaaaat aaaacgcaag ggaattacag aaggcgggag cgaaacatat 380101 gagtcaattt agcaaggatc aggttcaaga tatgtattac ctatcgccga tgcaggaagg 380161 gatgcttttt catgccatcc tgaatcccgg ccaaagcttt taccttgaac aaatcacgat 380221 gaaagtaaaa ggcagcttga atatcaaatg tcttgaagaa agcatgaatg tgatcatgga 380281 ccggtacgat gtatttcgta ccgtgttcat tcacgaaaaa gtaaaaaggc ctgtccaagt 380341 cgtattgaaa aaacggcagt tccatataga agaaatcgat ctgacacact taacgggcag 380401 cgagcaaaca gccaaaatca atgagtacaa agaacaggat aagatcaggg gttttgattt 380461 gacgcgggat attccgatgc gggcagccat tttcaagaaa gctgaagaaa gctttgaatg 380521 ggtgtggagc taccaccaca ttattttgga cggatggtgc ttcggcatcg tcgtacagga 380581 tctatttaag gtatacaatg ctctgcgcga acaaaagccg tacagcctgc cgcccgtcaa 380641 accgtataaa gactacatca agtggcttga aaagcaggat aaacaagcat cactgcgtta 380701 ctggcgcgaa tatttagagg gctttgaagg acaaacgacg tttgcggagc aaagaaagaa 380761 acaaaaggac ggctatgagc cgaaagagct gctcttttca ctgtcggagg cggaaacaaa 380821 ggcctttacc gagcttgcaa aatcgcagca taccactttg agtacggcgc tgcaggcagt 380881 ctggagcgta ttgatcagcc gctatcagca gtctggcgat ttggccttcg gtacagttgt 380941 ttcagggcgt cccgcggaaa tcaaaggcgt tgaacatatg gtcgggctgt ttatcaacgt 381001 tgtcccgaga cgtgtgaagc tgtctgaggg tatcacattt aacggcttgc tcaagcggct 381061 gcaggagcaa tcgctgcagt ccgagccgca tcaatatgtg ccgctttatg acatccaaag 381121 ccaggccgat cagccgaaac tgattgacca catcattgtt tttgagaact atccgcttca 381181 ggatgcgaaa aatgaagaaa gcagtgaaaa cggctttgat atggtggatg ttcatgtttt 381241 tgagaagtcg aattatgatc tcaacctgat ggcttccccg ggagatgaga tgctgattaa 381301 gcttgcctat aatgagaatg tgtttgatga ggcgtttatc ctgcgcttga aatctcagct 381361 tcttacagca attcagcagc tcatccagaa tcctgatcag cctgtcagca cgatcaacct 381421 cgttgacgac agggagagag aatttttgct aaccggctta aacccgccgg ctcaagctca 381481 tgaaacaaag cctctgacgt attggttcaa ggaagcagtg aacgccaatc cggatgcacc 381541 ggcgcttacg tattccggcc agaccctgtc ttatcgcgaa ttagatgagg aagcgaaccg 381601 cattgcacgc cggctgcaaa aacacggtgc gggcaaaggc tctgttgtag cgctgtacac 381661 gaagcgctca cttgaactgg tgatcggcat tctcggtgta ttaaaggcgg gagcagccta 381721 tctgccggtt gatccgaagc tgccagagga ccgaatctcg tatatgctgg ctgacagtgc 381781 ggcagcctgt cttctgacgc atcaggagat gaaagaacaa gcggctgagc tgccgtatac 381841 aggcacaacg ctcttcattg atgatcaaac acggtttgaa gaacaggcaa gcgatcctgc 381901 aaccgcgatt gatcctaatg atccggcata tatcatgtac acgtccggca caaccggaaa 381961 gccaaagggc aatatcacca ctcatgccaa tattcaagga ttggtcaagc atgtagacta 382021 catggcattt tctgatcagg atacgttctt gtctgtttcg aattacgcct ttgatgcatt 382081 tacctttgat ttctatgctt ctatgctgaa tgcggcacgg ctcattatcg cagatgaaca 382141 tacgctgctt gatacagaac ggctcacaga tctgatcctg caagagaatg tcaatgtcat 382201 gtttgcgaca accgcactat ttaatcttct cacagatgcg ggagaggatt ggatgaaggg 382261 gcttcgctgt atattattcg gcggagagcg cgcgtcagtg cctcatgtca gaaaagcgct 382321 gcggatcatg gggccgggca agctgattaa ctgctacggg ccgactgagg gaacagtgtt 382381 tgcgacagct cacgtcgtgc atgatctgcc ggattccatc tcctcattgc cgatcggaaa 382441 gccgatcagc aatgccagtg tttatattct gaatgagcaa agccagctcc agccattcgg 382501 ggcggtcggt gaactgtgca tcagcggaat gggcgtgtca aaagggtatg taaatcgtgc 382561 tgacctcacg aaggaaaagt ttatcgagaa cccgttcaag ccgggagaaa cgctttaccg 382621 tacaggggat ttagcgcgct ggctgccgga tggaacgatt gaatacgccg gccgtattga 382681 cgaccaggtc aaaatacgcg gacaccggat tgagcttgaa gaaatcgaaa agcagctgca 382741 ggaataccca ggtgtgaaag atgcggtcgt tgtggcggac cgccatgagt ctggcgatgc 382801 atcaatcaat gcctaccttg tgaaccgaac gcagctttca gctgaagacg tgaaggcgca 382861 cctgaaaaaa cagcttcctg cttacatggt gccgcaaacc tttaccttct tggatgagct 382921 tcctttaacg acgaacggga aagtcaataa acggctgctc ccaaaacctg atcaggatca 382981 gctggcggaa gaatggattg gaccgcggaa cgagatggaa gaaacaatcg cacaaatatg 383041 gtctgaggtt ctcggcagaa agcaaattgg cattcatgac gatttctttg cgctcggagg 383101 gcattccttg aaggccatga ccgccgcgtc ccgcatcaag aaagagctcg ggattgatct 383161 tccagtgaag cttttgtttg aagcgccgac gatcgccggc atttcagcgt atttgaaaaa 383221 cgggggctct gatggcttgc aggatgtaac gataatgaat caggatcagg agcagatcat 383281 tttcgcattt ccgccggttc tgggctatgg ccttatgtac caaaatctgt ccagccgctt 383341 gccgtcatac aagctatgcg cctttgattt tattgaggag gaagaccggc ttgaccgcta 383401 tgcggatttg atccagaagc tgcagccgga agggccttta acattgtttg gatattcagc 383461 gggatgcagc ctggcgtttg aagctgcgaa aaagcttgag gaacaaggcc gtattgttca 383521 gcggatcatc atggtggatt cctataaaaa acaaggtgtc agtgatctgg acggacgcac 383581 ggttgaaagt gatgtcgaag cgttgatgaa tgtcaatcgg gacaatgaag cgctcaacag 383641 cgaagccgtc aaacacggcc tcaagcaaaa aacacatgcc ttttactcat actacgtcaa 383701 cctgatcagc acaggccagg tgaaagcaga tattgatctg ttgacttccg gcgctgattt 383761 tgacatgccg gaatggcttg catcatggga agaagctaca acaggtgttt accgtgtgaa 383821 aagaggcttc ggaacacacg cagaaatgct gcagggcgaa acgctagata ggaatgcgga 383881 gattttgctc gaatttctta atacacaaac cgtaacggtt tcataaatga agtgatgaaa 383941 ggaggagaca gccaatgagc caactcttca aatcatttga tgcgtcggaa aaaacacagc 384001 tcatctgttt tccgtttgcc ggcggctatt cggcgtcgtt tcgccctctc catgcttttt 384061 tgcaggggga gtgcgagatg ctcgctgccg agccgccggg acacggcacg aatcaaacgt 384121 cagccattga ggatctcgaa gagctgacgg atttgtacaa gcaagaactg aaccttcgcc 384181 ctgatcggcc gtttgtgctg ttcggacaca gtatgggcgg aatgatcacc ttcaggctgg 384241 cgcaaaagct tgagcgtgaa ggcatctttc cgcaggcggt tatcatttct gcaatccagc 384301 cgcctcatat tcagcggaag aaagtgtccc acctgcctga tgatcagttt ctcgatcata 384361 ttatccaatt aggcggaatg cccgcagagc ttgttgaaaa taaggaggtc atgtcctttt 384421 tcctgccttc tttccgatca gattaccggg ctcttgaaca atttgagctt tacgatctgg 384481 cccagatcca gtcgcctgtt catgtcttta acgggcttga tgataaaaaa tgcatacgag 384541 atgcggaagg gtggaagaag tgggcaaaag acatcacatt ccatcaattt gacggcgggc 384601 acatgttcct gctgtcacaa acggaagaag tcgcagaacg gatttttgcg atcttgaatc 384661 agcatccgat cattcaaccg tgatcaaaag cggacagctt cggctgttcc gctttttttg 384721 tgttgaatgc caatttctgc atggtataat agtcgaaata ctcaaataaa ggcaggtcga 384781 aacatgcgca cgtctcccag gatgaaatgg tttgtattgc tgtttacgtt tgttttcgcc 384841 atcggaatga actcattcag aaattccttt caatttttta tgctgccaat ggcagacgcc 384901 ttccatgccg acaggtcgct gatttcggtt tctgtcagca tttttatgat cacaaccggc 384961 atcgtccagt tttttgtcgg tttttttatc gaccgtttca gtgtcagaaa aattatggcg 385021 ctgggagctg tttgcatcag cgcaagcttt ttggtgcttc cttattcacc gaatgttcat 385081 gtgttttccg ccatttacgg tgtgcttggc ggaatcgggt attcctgcgc ggtcggcgtg 385141 acgacccagt atttcatcag ctgttggttt gacacacaca aaggtctggc gcttgctatt 385201 ttgaccaatg ccaactctgc gggcctgctg cttctctcgc ccatttgggc tgcggctccg 385261 tatcatgccg gctggcagag cacctatacc attttgggaa tcgtcatggc ggctgttctg 385321 ctgccgctcc tcgtctttgg gatgaagcac ccgccacatg cgcaagcgga aactgtgaaa 385381 aaatcttatg attggcgagg gttttggaac gtgatgaagc aatcccgcct cattcatatc 385441 ctgtacttcg gcgtgtttac ttgcggattt acaatgggaa ttattgatgc tcacctcgtc 385501 ccgatactga aggatgcgca tgtctctcat gtcaacggaa tgatggccgc gttcggggca 385561 tttatcatca ttggcggatt attggcgggc tggctgtcag atctcctcgg cagcagaagc 385621 gtcatgctat ccatcttatt tttcattcgg ctgctcagcc tcatttgcct gctcattccc 385681 attctcggaa ttcatcacag cgacctttgg tacttcgggt ttatcctgtt attcgggctc 385741 agttacacag gcgtgatccc gctgaccgcg gcgtcaattt cggaaagcta tcaaacagga 385801 ttgatcggat cgctgttagg catcaatttc tttatccatc aggttgccgg agctctcagc 385861 gtgtatgcgg gcggtttgtt ttttgacatg actcatggtt atttactgat tgtcgctgtg 385921 tgcatcgtgt ttgtgggttt atcggctgta atagagctgg tgccgttttt agataaacag 385981 aaggcaaaag aaacccacca ttcaatataa aaggatcagc actgtcaatg ctgatccttt 386041 ttaaatttga gtttttttgt ttcggtattt ttaaggataa tctccttgaa tctgttcatc 386101 tcctcttcgg agtgaaaaaa atgtttgggg atcgcaatat attggccact tgatgtattg 386161 accctgaaga tatttttata ttcgaaaaca gctgtaattt catcccaatt gaaaatgagg 386221 tcatattttt tagaacatat acgaattcct tcttggttca gagtatatgt tcttttggat 386281 ttcatccgtt cgttcttctt gtatgctctg gaaaacttca catatagaag aaggaggagc 386341 agcagtgtaa acagaacgga catcacgata atcaacatac tgttcataaa caagttaagc 386401 gcgtcacttc cataaacgat acggggccat ccgttaatga agttaactgc agcaaatatg 386461 gcgcaaaaca atagaaagta aaagcatgat atttttgcga tttgataaaa aaagatttct 386521 cttacatcct taaaagtgat ttctcctgga agattgatac tttcactagc atattgaatc 386581 atacggtaaa cctacacctc taaccatgtt tttcctttta gtctagcata atttctcatt 386641 tttttgcagg cataccaggg cgctttgttt ttttctccag attgatattg ctccccacca 386701 cgccaatcat aatacaaaca gccccggcaa gatgatacca ggccaggctt tcgttgagaa 386761 tcacaaatcc tgcaatcatc gtcacaatgg tagatacatg attaaaagcg ctcattttaa 386821 acgcctcaat tcgcgacagc gtatagttag acagaaatga agtgacaagt gaagacagca 386881 cgcccaaata cacaatggcg agaacgaagc cgggctcccg gaacggcaga aaataagtgc 386941 cgactgttcc cgccgctccg tgacgcacaa gggcgatggc gttgaagacg acaaagccga 387001 tggctgacat gatgtaggtg agctcggtca gcttgaaccg ctgcgtcatt tttctggcag 387061 cagtattgta catcgctgaa gacaaagcgg acaataggat cagcaaagac ccttttaagc 387121 tggctgattc cacgtcaacg cctttcatca caaaaataaa catgacgccg gcaacggata 387181 aaaccgtgaa ccccttttgc gtccacgttg ggcgttcctt taaaacataa gcggcaaaga 387241 ccatcgtgaa aatcggaatg gctgcctgaa taattcccgc ttcagaggag gacgagtaca 387301 caaggccgaa tgcctgaaag ctgaaaaata acgcgggata cagcagggcg agcggcaaaa 387361 tgtcaatgac gtcctttacg cggattgata gctttaccca gccgaataag atcggtacag 387421 tggccgcagc aaacgcaatg gtgaaccgat gcgccaaaat atcaaacggc tctgctgttt 387481 gcagtgcgat ttttacgaat agaaaggata aaccgataat gaacgaatat aaaatagccg 387541 ctatataagc gggggtttgc tgatgtttaa ccataatggg aagggctcct ttacctgaat 387601 tgcagcgccg gtcgctccct ttattgtatg gccgcggtca gaacggtaca atgagaaaaa 387661 caatgaactg taccggtaca aaacaggggg agaaggcatg gagaaatata tgagtctatt 387721 aacgaggata gaggagatga tgcaaagcac ctcatatcaa gaaggagaca ggcttccatc 387781 tatccgtcag ctgtccgccc gctaccaagt cagcaaaagc acagtgatcc gcgcgctgca 387841 ggagctggaa aagcgccacc ttatctattc tgttccgaaa agcggctatt atattgtgaa 387901 aaagtcaggg aaatcaaaaa gcgggcagcc tggccccatc gactttgcca catctgcgcc 387961 ggatcccgat gtgtttccgt atcttgattt tcagcactgc atcaacaaag cgattgatac 388021 atacaaaaac gatttgttta tttatgggac gccaaagggg cttccatcac tcatccgcgt 388081 actccgaaag ctcttggcca ctcaacaggt atttgcggat gaacggcata ttttcattac 388141 atcaggtgtc cagcaggcgt tatccttgct ttgtgccatg ccgttcccaa atgggaaaga 388201 gaagatcgcc attgaacagc cgggctacca tttgatggtc gaacagcttg agacacttgg 388261 gattcccgcc atcggggtga aacgaacgga agaagggctt gatatagcca aggttgagcg 388321 gttatttcaa acagaatcga ttaaattttt ttatacgatg ccgcgcttcc ataacccgct 388381 tgggtgctca ttgtcagagc gtgataaaca ggagcttgtg agactggcag aagcgtatga 388441 tgtctatctc gttgaggatg attacctcgg tgatctggag gaaaataaaa aggcagatcc 388501 gctgtacgca tatgatctgt cctcacatgt catctatttg aaaagcttct cgaaaatgat 388561 gttccccggc ctccgcgtgg gggcggctgt tttgcccgaa gcgctgactg acacgttcta 388621 tgcgtacaaa aagctgaacg acatcgactg ttcgatgatt tctcaagcgg cattggagat 388681 ttacctgaaa agcggtatgt acggcaggca taaggagaaa atcagagatt cttataaaga 388741 gcggtcgctg aggctacatc aagccattcg aactcacagg cagctgggaa gcggacgctt 388801 tacgttctcc agcgggcagg caccctgtat gcacacccat ctggtgcttc ctcaggatct 388861 gcccgcctca agagtgattc atagactgga aaaacaaggg gttctccttg aggcgataga 388921 ccgtcattat ttatcagatt atccgaaaga aaatctatta aaaatcaata tttccaatgt 388981 gaaaacggaa gatattgagc gcggtgtcaa gctgttgatg agccatttat aaaagctctt 389041 cgtacgagac cattgtgata tcctcgggga aatcagggtg tacggcgcat acagccattt 389101 tgtagccggg atcgacctca tacgttttga tatagcatgg ggaatggctg tccggaagct 389161 caatggatac ttgtccgtcc tggtgcaggc gcactgaaaa ggaatcaagc ggaagcgata 389221 agcctttgcc ttccttgttt gataaagctt tctttcattg accatagatg ataaaaatag 389281 tctgtctgct cgtccttgtc ttttgctaaa aggtcgctgt actctgtttt tgaaaagaag 389341 cgcttggcga tctcaaggct gatcggtttc gttttttcga tatctatgcc gatcggctgt 389401 gaatcaaacg cgcaaatgac ccagcgtccg gagtgagaaa tgttgaaatg agcgtcggga 389461 agatcaggga tgcacggctt cccgtattcc tgcgtgctaa agcggatatc ggatttgtcc 389521 aactgatact gcctgcttat gactgagcga acgagcacat ctcccagcag ggtgcggtga 389581 gcatcttctt tatgataaaa tctccggcat ttctcccgtt tttcaggtga tatgaaagac 389641 atgaaccgtt cattttcttc ctgtgaaagc gggcggtcca tataaattcc gtaaatcttc 389701 attctagatc ctccgtctgc aaaagattgt caaaaccatc ctatcatact tccacaagac 389761 tcatatagag gagaaaataa aaaaacaaag ccaaggcggc tttgttttag tgtacaggcg 389821 gagatgcttt cactgcggct gtccgccttg ccacagcata attcagcaac tggattgact 389881 ggggcaatga aaaacgcaaa ataagtccgg tgaggatggc ggtcaaaatg gtgccaaaac 389941 cgatcggtcc gcccatgccc catgccgcaa acaaaatggt taattccatg ccgttccgca 390001 cccattgcac attccagccg gttttttctg taatcagcat catcagtgaa tcacgcggcc 390061 ccgcgccaag gcctgctgat acataaacac cgacgccgta accaatcagc accacgccta 390121 gagagaagac gatgatcgag cctgtgtagg tcgagagggc aggcagaatg aaattgaaaa 390181 aatctataaa tacaccaatg agcaccatat tcaggagggc accaattttc ggccaagctc 390241 tcgtaaacaa tgacgtgaat ccgacgatga gcgctccaat aatgatggac cactggccga 390301 cggtaagccc gaagtgctga aacaggctgt aatgaaatgc atcccacgga ctaatgccga 390361 gtgcttttcc ttctatcgtc agggatacac caaaagccaa aatgatcaaa ccggcaaaat 390421 aaaatgtcca gcgcagaaca agttcttgct tcacgtgagg tcccttcttt cgtaaaaatc 390481 agtcgattgt cattgtagca catctgacag aagggcggaa taggcgaaag gggctcaaca 390541 aaaaaacagg gccgccggag gcgccctgtt tcagcgtgtt ggcaaaccct tgcattcgtt 390601 gtcaggcctg tgcttcggtg ctcacgaatt taacattagc tgtgctccaa tgctcgccct 390661 tcctagactt caaaggtttt caatcacgct gaaaatcaca aaatcctaaa acgaatatcg 390721 ttttaggatt ttgtcaataa tctgaaacag ggcgctgacg ctctgttttt cttattacag 390781 cgggttcaaa atccggttta agaaccgctg tgtccgttct tcttttggtg cggagaaaat 390841 ttgctccggc ggtccctgct ccacgataac gccgccgtcg atgaagatga cttcatccgc 390901 aacctcctgc gcgaacttga tttcgtgggt cacgacgacc atggtccagc cttcattggc 390961 caagtccttg ataaccttca gcacctctcc gacaagctcg ggatcaagcg ctgaggtcgg 391021 ttcgtcaaac agcatgagct caggctgtat cgccagtgcg cgggcgatgc cgacgcgctg 391081 ctgctggccg ccggaaagct ggaacggata taaatccatt ttgtccttca atccgacttt 391141 atcaagaagc tgaatcgctt cttttctgac ttcctctttg ttccgttttt gcacctgaac 391201 agggccctcc atcacgtttt cgagggctgt gcggtgcggg aacaggtgat acgcctgaaa 391261 caccattccg gattttcggc gaagctttag gatatccgcc tgtttcacct ttttggagaa 391321 atcgatggag aaatcatcaa atgcaagctc tccgcgattc gggatctcca gagcgttcag 391381 gcagcggagc agcgtcgttt tccctgaacc tgaaggccca agtatggcga tgacttttcc 391441 tttttcaatc ttcatatcta tcttttttaa aatttcattt tcaccgaatg atttgtttaa 391501 tcctttaacg gtaagcatac tcggaacctc cttatttggc cacgtagcgg tcaagacgcc 391561 gttcgatgac atgctggacg agtgagagca ggaagcagat aatccaataa ataaaggctg 391621 cttcaatata gatcactaaa atttgatcaa gattccgcgc gccgatttcc tgggcttttc 391681 tgaacagctc agcgaccaga atttgagagg cgagggatgt atctttaatc aggctgataa 391741 aggtattgga taatggcggg atcgacacac gaaacgcctg cggcaaaatg acgcggaaca 391801 gcgttttttg atgtgtcatg ccaattgtgt agccggcttc ccattgccct ttcggcacgg 391861 ataaaataga tgcccgaatg atttcagatg cataggcgcc gacgtttaat gaaaaggcga 391921 taactgcgct tggaaatgga tctaatgtga cgttaaaggc cgggaacaga tagaaaatga 391981 tgaacaattg aacgagaaga ggagtgccgc gtattgcgga tacgtatacg ctgaacaccc 392041 atctcaaagg tctcactttc gacattctgg caagcgccgt aatcagcgcc aggatcattc 392101 cgaatataaa ggaaagaatc gtaaggggaa tcgtatagta gattccccct gaaagtatcg 392161 gccagaatga ctgctgcacc agatcccacg ggatcgccgt gccaagcgtc aatgccggca 392221 gattatttag aaacatcttc gccgaaccat tttttagaaa ttttagaaag agtcccgtcc 392281 tctttcattt cttttaatgc tttgttgact tgatcaacaa cctcgccgct tcctttacgg 392341 aacgtgaaat atgttgactg aggctcacct gtttcaaacg cgattttcac gtttttattg 392401 ccagatgttt ttaagtagtt caatacggca agcttatcgt tgtatgtcat atcgacgcgg 392461 ccttgctgga tcatttgaag ggcctgcgcc atgccttcaa cgccttctac tttagcgccg 392521 gcatttgtag ctaatttgtt gtagttgctt gtcagtgatt gagctgacgt ttttcctttt 392581 acatctgctt cagacttaat atcgttgttg tcttttttcg ttacgacaac ggctcttgat 392641 gttgtgtatt tatctgagaa atcatatttg tcttcacgat ctgtttttcc gacttggttg 392701 gcaacaacgt caaaccgttt ggaattcagg ccggcaaaca tactgtccca ttgtgtttcc 392761 ttaaagtcga ctttaagccc gaggcgtttt gcgacttctg tgataacttc gacatcatag 392821 ccagtcagtt tatcagtgtc tttgtcgtgg taagtgaacg gctcatatgt tccttccgtt 392881 ccgactgtga gcacaccttt tttcttaatt gaagcccaaa gatcgccatc tttggcatta 392941 tcttttgact gattgtcatt tcctgctccg caagctgcaa gagctgcaat acttacgacc 393001 atgaataaag ccaataatgc ttttttcatc ttattcccca cttttctggt tgattttatt 393061 gaaataaaaa attagcttac aaatctaaag gataactttt ttttagtatg agtcaagtat 393121 ttggttttca taagacaaaa tcttttaaaa taaatccaaa aattgctgtg ccggtttagg 393181 caaataactg tccgttctcc acatgacagc cggtgtcata atgaagggat tattttcgat 393241 atggacggtg tgaacgtgat ttctcatatg aacgggaatc attgtgacag gcaaaataga 393301 cgcgccgaat ccggatgaca cgaggctgag caaagttgca gagtcgtggc attcacaaac 393361 aatgcgcggc tccaggttca aacgatgaaa ttcattcatg acctgattat agacgccttt 393421 tccgttgaca ggccgcagca ggatcagcgg aaatgaagga atgtccacca tcttaatggt 393481 gtctccgcac ggatatccgg cttcatctga aagcacgagc acacatggaa tgtcatcaag 393541 ctgcttgaat tgtactgtgt cacttttgat cagtgttgtc gtgaccgccg catcgatttg 393601 ccggctttcc agcagttcca acagtgtcgc gggttcattt tcccaaatat taaaggtgag 393661 atgggggtat ctctctttga tctgtgttac tttttcaagc atcagagccg cgcaataaat 393721 cgttgatccc acggcaagtg taccggctac ttcctccttc agctcctgta cctcaatgac 393781 tgcatcttca aacctatgca gaatctcttt tgctcttttt agaaaaacag ctccttcata 393841 tgtaagagtc atttgttttt tcttgttacg gtcaaacaga acaacaccaa gttcgtcctc 393901 cagctgtttg agctgcctgc ttaaaggcgg ctgcgccatg tgaagctttt tggctgcgga 393961 cgtaattttc tgttcttggg caatggtaat gaagtatcga agctggcgaa tatccaaaag 394021 aaagcgcctc cttatcatac cttttaggta ttaattatag atttaataga tatttttcat 394081 atggatatat caggagtatg attgaaatga aagcagaatt caagcgtaaa ggagggggca 394141 aagtgaaact cgttgtcgga atgacagggg caacaggggc cattttcggg gtcaggctgc 394201 tgcagtggct gaaggccgcc ggagtggaaa cccatctcgt tgtgtctcct tgggcaaacg 394261 tcacgatcaa acacgaaaca ggctatacgt tacaagaagt agaacaactg gccacataca 394321 cttactcaca taaggatcag gcggcagcca tttcaagcgg gtcgtttgat accgatggaa 394381 tgattgttgc gccgtgcagc atgaaatctc tcgcaagcat tcgcacagga atggcggata 394441 atctgctgac acgtgcggcg gatgtcatgc tcaaggagag aaaaaaactc gtcctcttaa 394501 cgagagagac gcctttgaac caaattcatc tcgaaaatat gctagcgctt acgaaaatgg 394561 gcaccatcat tcttcctccg atgccggcat tttataatcg gccgagaagc ttagaggaaa 394621 tggttgacca tattgttttt agaacgttgg accaattcgg cattcggctt cctgaagcga 394681 agcgctggaa tgggattgaa aaacaaaaag gaggagcttg atcatggctt atcaagattt 394741 cagagaattt ctcgctgccc ttgaaaaaga aggacagctg cttacagtga atgaagaggt 394801 aaagccggaa ccggatttag gggcctccgc acgggcagcc agcaatcttg gcgataaaag 394861 ccctgcgctc ttatttaaca acatttacgg ctatcataac gcgcgaattg cgatgaatgt 394921 catcggctct tggccaaacc atgccatgat gctgggcatg ccgaaagaca caccggtaaa 394981 agaacagttt tttgaattcg caaagcgtta tgaccagttt ccgatgccgg tcaaacgtga 395041 ggaaacagcg ccatttcatg aaaatgaaat cacagaagat atcaatttgt tcgatatact 395101 gcctcttttc agaattaacc agggtgatgg aggctactat ttagacaaag catgtgtcat 395161 ttcccgtgat cttgaggacc ctgacaactt cggcaaacaa aatgtcggca tttacagaat 395221 gcaagtcaaa ggaaaagacc gccttggcat tcagcctgtc ccgcagcacg atattgcaat 395281 ccatctgcgc caagctgaag aacgcggcat caaccttccg gtcactattg cgctcggctg 395341 tgagccggtc attacaacgg cggcatcgac tccgcttctc tatgatcaat cagaatacga 395401 aatggcaggt gcgattcaag gcgaaccata tcgcatcgtc aaatcaaagc tgtctgatct 395461 tgatgttccg tggggcgctg aagtggtgct tgaaggtgag attattgccg gagagcgcga 395521 atatgaaggg ccgttcggtg aattcacagg ccattattcc ggcggacgca gcatgccgat 395581 tatcaaaatt aaacgcgtct atcacagaaa caatccgatc tttgaacatt tatacttagg 395641 catgccttgg acagaatgcg attacatgat cggcattaac acatgcgtgc cgctttatca 395701 gcagttaaaa gaagcgtatc cgaacgaaat tgtggcagtg aacgccatgt acacacacgg 395761 tttaatcgcg attgtttcca caaaaacccg ctatggcgga tttgcgaaag cggtcggcat 395821 gcgcgcactc acaacgccgc acggactcgg ctactgcaaa atggtcatag tcgttgatga 395881 ggatgtcgat ccattcaacc ttccgcaggt catgtgggcg ctttcgacca aaatgcatcc 395941 gaaacatgat gcggtcatca ttccggactt atctgtcctg ccgcttgatc cgggatccaa 396001 tccatcagga atcactcaca aaatgattct cgacgccact acaccggttg cgccggaaac 396061 aagaggccat tattcacagc cgcttgattc tccgctaaca acgaaagaat gggaacaaaa 396121 actaatggac ttaatgaata aataaggaaa ggatgttcga aatgcataca tgtcctcgat 396181 gcgactcaaa aaagggagaa gtcatgagca aatcgcctgt agaaggcgca tgggaagttt 396241 atcagtgcca aacatgcttt tttacatgga gatcctgtga accggaaagc attacaaatc 396301 ccgaaaaata caatccagcg tttaaaattg atccaaagga aacagaaaca gcaattgaag 396361 ttccggcggt gccggaacga aaggcttgat ccgcgtgaac tgtatgtcag accgtctctt 396421 tgagctgctt gacgggagct gcctgaatga gaagcagcat gaggccttcg ttctgcaaac 396481 agtatcagag gatggctggc cgcatgccgc tatgatcagt gcaggtgaaa tcatcgcgct 396541 gagccgaact gatatccgaa tcgctctgtg gaaaaacaca atgacttcgg ccaacatcct 396601 tcgcacagga aaagcacagt tcacggcgtg gtggaaggga gcggcctatt atgtaaagct 396661 tgaatgcgcg cctttaccgc ctttgaaaga tgccgaatat gaaagagacc gtttttcctg 396721 ccgcatcgtt tcagtgaaag aggacgttgc gaaatacgct gatttgactt caggtgtccg 396781 tatacagctt cacagccctg aagaggtgct gagcagatgg aaaaagaccc tggaagattt 396841 aaaacggtaa tatcgatagc ctgacgccat gcgtcaggct ttttttatat aatgaaaaca 396901 aaagggggcg tgagaaatgg aacgtgcggg gatctgtcac tcggacggct ttgatttagc 396961 ttatcgaatt gagggcgagg gcgcacccat ccttgtgatc gggagtgcgg tttactatcc 397021 gcgccttttt tcctcagata tcaaacagaa atatcaatgg gtctttgtcg accatagggg 397081 atttgctaag cctaagcggg agcttcgtgc ggaggattcg aggcttgatg ctgtcttggc 397141 tgatatcgaa aggatgagaa catttcttca gcttgaggat gttactatcc tgggacattc 397201 cgggcacgct tttatggctt tagagtatgc caggacatat cccaaacaag ttcggaaggt 397261 ggcgctcttt aatactgcgc ctgataacag tgaagaaaga cagcgaaaaa gcgaatcatt 397321 tttcatggaa acagccagtc ttgagagaaa gaaacgcttt gaaaaagaca tcgagaattt 397381 gccgcaggac atcgacaaag atcctgaaag gcgctttgtg cacatgtgta ttcgcgctga 397441 agcgaaaagc ttttatcaag agcggccgca tgctgctgcc ttatgggacg gtgtattcac 397501 gaatatgccg atcattgatg aattatgggg caatacattt gcccggattg atcttcttca 397561 gcggttagct gatgttcgta tgccggtgta tatcggatta gggagatatg attatttggt 397621 tgcgcccgtt tcgctatggg atgctgttga cggtttatat ccccatgttg ataaggttat 397681 ttttgaaaag agcggccatc agccgatgct ggaagaaccg gaagcctttg atcaaagctt 397741 caggaaatgg cttgatcaat aaaaaacagc ccgcagatca acatccgcgg gctgtttctg 397801 attataagac ccctttcatc gcgcgtttga tcaccggcga gagcagcagg agaatgccgc 397861 caagaacgat agaaatcaaa ccgatggtgc cgaagtacat tgtttcagga attttatcaa 397921 acaatccggc tacttgggca ttgatcgctt gggctgctgc gttcgtcaga aaccacatac 397981 tcattgtctg tgcagagaag gcagctggtg ccagtttcgt tgtcacggat aaaccgactg 398041 gagacaggca cagctctcca agcacgacaa gcaggaagct gagaacgagc caaagcgggc 398101 ttacgagtgc ttcttttcct tgcatagcag ggaataccat aatgataaat gacaatccgg 398161 ctaaaataat tccgattgag aatttaactg gtgtagacgg ctgacgtttg ccaagcttca 398221 tccagagcca tgcgaatatt ggcgcaaaaa tgacaacaaa caatggattt aatgattgga 398281 accatgatga ctgaagttcg aatccgccca atgaaagtct tatgcgttca tcagcgtata 398341 ccgcaagaat ggtcgctccc tgttcctgaa tggcccagaa catgacagca ccgataaaca 398401 aaggaacgta agcggcaaga cgggattttt ctgttttgtc cgcttttttg cttgtaaaca 398461 tgatgatgaa ataaatcaca ggaatcaaaa taccgagaat acttacaagg tcaatgaaac 398521 gtttgatcgt cagcacgcct gtttgtacag agataatcac tgcgatcgcc acaatgataa 398581 caccgattcc ggtgccaatt gcagattttt tagacagcgg attcggcaca ttggaacctg 398641 caagcccgag gtttttcttt cttgtcaaag caaatacgat aagtccgaga agcattccga 398701 ccgcggcagc tccgaatccg agatgatagt tgtacttctg tccgagtgtt ccgacaatta 398761 acggcgcgag taaaccaccg aggttaatcc ccatgtagaa aatactgaaa cctgagtcgc 398821 ggcgcgggtc ttctttcgtg taaagatccc caactacgct tgaaacgttt ggttttaata 398881 agcctgttcc gacaatgata agcaccatac tgatatagaa tgctatcgaa ctgcccggat 398941 aggcgagtgc aatgtggccg aacataatga atatgccgcc gtaaaacacg gtgtttgcgg 399001 taccgaatac ccggtcagcg agccatccgc caataatggt ggacatgtat acgagtgatc 399061 cgtaaatcga cataatggca accgcagtgc ccttgtcaaa gccgagccct ccgtttaccg 399121 tctctgtata caaatagtaa agtaagattg ctctcattcc atagtaagag aaacgctccc 399181 aaaattcggt gaaaaatagt gtaaatagtc ctcgcgggtg accaaagaac cctttttgcg 399241 ggacgctttt aatgatactt tcgttatcaa tcgaagccat gtcagccaaa ccctttctaa 399301 aaaaagtgta ttataaaaat catattctta tataatactt gtgtcaatat aatttatact 399361 catttcaaat agttccatat tggaaaaatt ataaatacct aaaaatagtg atttcctcct 399421 aatttttaaa ctttttatcg tgagattttc ttacacaact attcctttat atttttttaa 399481 taaaatttta gagaaatgta caagcagatc gggcctttgt gagtaacatg atagtaatca 399541 tagagaagga ggctcgcaat tggctgaatt catattaaat gcagcggatt tcggtgttcc 399601 tagagatggt aaaacggatt cgacagaacg gattaatcag tgcctcagta cagctgtttc 399661 gaaaggctat catactgtct ggtttccaaa gggaacatat ttaatagacg caacgcttgg 399721 cggagatctt aatcagaggt ttcgaaacgc ggggatcatt gttcccggca accttgagat 399781 tatgatggac cccgaatgta tcatgaaagt gataccgaat agttcgtggg gttattccgc 399841 attttatgta ggcaagcaag agaatataac tatttccgga ggacaaatta tcggcgaacg 399901 ggatgagcat acgtatgcct cggcggggat aaggtcaacc catgaatggg gctttggcat 399961 atgtattgaa ggatgctcga atgttgtcat tgatgatgtg aaaatttccg attttaccgg 400021 cgatgggatc atagtcagcc caaggggatt aaagaccaat caagattatc gaacgtcaga 400081 gcaaattatc atccgccgct gtgaggttcg gcggtcgagg agaaataaca tttccattac 400141 cggatgtgac atggtcacgg tggaggaatg cttgattgaa gatgccggaa cggggaatgg 400201 aacagcgccg aaattcggaa ttgacattga aggatatggc gaaggtgacg ttgattatga 400261 ggaaccgatt aatgtatcaa ttcgcaataa ccactttgtt ggaaacgttt caagttctgt 400321 gaccaatttt aacgggtatg gcattttaat agaaggaaat cactcagaca atacaatcag 400381 ctacggatat gggacgcaaa cagtgatcaa gggcaatatt ctgagacgcc ctgaagacgc 400441 ggcggctgcg ccaagagtcg ggataaccgg actcggtgta tcacaaggaa aagagaccag 400501 tgatgcagtg atcgctggca acctcattac cggattttca actggaattg atgtcagggg 400561 aaagagcgtt cttgtgacga acaacaaaat cagcaacttt gaaaacacag ggatattggt 400621 ttatcagtcc tccgacgtaa aggtagacgg aaaccaaatt caaaacggac tgtctgaaac 400681 aaggcgcagc atcggtcttc gcgcagtgct gtcagatgac atcgcatttc tgaataactg 400741 tctcattcaa gtcgttgacg gtgtgaacgt ttccggcgga aatatgatca ttaaagataa 400801 tctcctgaga aaattcagcc ggggcatttg gattgctcaa gggaacgcgg tgattgaagg 400861 gaatacactg aatcctgacg cgtttgaagc agtgccggaa tcatattctg tttccgtcac 400921 aaacaatgcc ggcgccatca tcaaaaacaa tacatttaaa gagttcaaaa attaccccat 400981 ttattgctcc acaagtgcaa aaacctcaat tatcggcaac cacttagagc gatccccgct 401041 tttggtcacc atctatatca gcgcaggtgt gcatgagatt tttgataata ccatttcagt 401101 caacagaaca gccgggaatc cgattgtgat ttatctcaat ggctctgcag gctctatcat 401161 ctctggaaac accatcaata acctctccgc gggcactgcg acagctattc aaacaaacac 401221 gtcaaccaat tccaaaatca tcggcaaccg catttttaaa gggaccatca acaaacacag 401281 cagtgataca atagacggca atatgattgt ctgaaaaaag cgcccccctt taggggttct 401341 tttttttcga tttatagatc acgtacattt ctctcacaag tactaacaca aaaaataaaa 401401 gcacgaccca ttccgcaaat gttgtcatct taaagctgga catattgtta taaacggctt 401461 ttgttaaact gaacccttga agcatgtcca tcaacacaga aatagctaat aaacaaatta 401521 atatgaatcc ggtcacgccc aatatcttca tgcttcatca tcctccgctt ttagtgtcta 401581 tctttggcgg agaagttata ccgcatctaa ccctaatgca taatctcaat tttaaaagga 401641 agaatatgag aaaacgacaa ggaaaggtat ttgtgtatgc ctttattttc taagcgaaag 401701 aacaataccg attcaaaaga caagcagaat acagacgaaa ggaatcagga acagcagcaa 401761 gaaaaagaaa ggccggttct catttctcca agtttagcaa agaatatagc ggaaacgaaa 401821 aaggaagtcg gaagcagctc tgacgtcatc attcgcgaga ttaaaatcgg ggagcaggat 401881 catgtccacc tagctgttat ctatatttct gggctggtcg ataataacac gatccatgag 401941 tcgttaattg acccattggt acaggatgag tctatccaga atactcatgc gatccagcaa 402001 attcttgaaa aaacgctccc gctgggcggg gtgaaagcgg aaaagagctg ggacaagctt 402061 ttttccgagt taatgcttgg caatgcgctc atttttgctg atggccatga tgaagctttg 402121 atttgcagca ctcaaggggg agagcagcgc tccatccaag agccgagcac ccaggtgtca 402181 ttccgcggcc cgcgccaagg gtttacagag tctctgcaaa ccaatatttc catgatccgg 402241 cgatacatta aaaatccgaa tttatgggtt gaaaaaatga aaaaaggttc tgttacgaat 402301 acggatatcg ctctcatgta cattcaagga atatgtgatg aaaaggtgct gaaggaagtg 402361 aaacagcgcc tggaaaaaat agatattgac agtattttgg aatctggata tattgagcag 402421 ctgattgaag atgaaacctt tacgacgttt ccgactatgt atcatacaga acgccctgat 402481 gttgtagcgg gtaatctgtt agaaggaaga ttcgcgatta ttgtggacgg aacaccgttt 402541 gtgcttattg ccccagcctt atttgtccag ttttttcagt ctgttgagga ttattattcg 402601 cgttttgaca ttgcgacaag cataagaatt cttcgtgttt tagtcttttt catttcgctt 402661 gtggcaccag ctgtatacgt ggcagccacg acgtttcatc aagaaatgat accgactcag 402721 ctgttagtgg tcattgcggc ccagcgggaa attgtcccgt ttccggctgt tgtggaggcg 402781 ctgacgatgg aggttgcttt tgagattctg agggaagcgg gagtcaggct gccccgggtt 402841 gtcggctcgg cagtgtcaat cgtaggcgcg ctcgtaatcg gccaggctgc cgtacaggct 402901 ggtatcgtct ctccggcaat ggtgattatc gtggcactca ccgcgattgc gagcttcgca 402961 acaccggcgt ttgcaatggc gatttcagcc cggcttattc ggtttatctt tattattgcc 403021 tcagctgtta tgggttttta cgggctgatt ttagggatca ttatgatgtt tgtccactta 403081 tgcagtcttc gttcattcgg cgttccatat atgtcgccgc ttgcaccttt ttcttcacaa 403141 ggcgtaaagg acgcgctttt ccgggttccg tggtgggccg atgaaaaaag gccggaatcg 403201 gtcagcaagg aagataaggt gcggcagggg aaagatcaac gcccagagcc ggccgcttca 403261 cgaggaatgg tgaacaaaga tttggaagaa ggggatcaga atggtacgta aatgtctatt 403321 agccgttctc atgcttttga gcgtcattgt gctgcccggc tgctgggata agcgggagct 403381 gacggatctt gcgattatct cggcgattgg catcgatcgg acaaacgaca gcaactacgt 403441 gctgcatctt caaattatca atccaggaaa tgttgccggc ggccttcagg gaggcggtgc 403501 tggagacagg ccgcctgtat ctgtctattc gattgaaggt aacaatataa cggaagcact 403561 cagaaaagcc tccatgaagg tatcacggcg gctttatttt gcccatacca atctagtcgt 403621 gatcaatgaa aagctggcaa aagaagaagg tttggatttt gtattagata atcttgaccg 403681 ggacacagaa ttcaggacaa cagcaacatt cgtcgttgcc cataaaacaa aagcagaaaa 403741 tattgtgaaa atcttgacgc cgattgataa aattccgtca aataaagtca ataaaacact 403801 cgatttcacg gaggcacaat acgggcgggt ggtcaaaatc aatattcagg acgttttgaa 403861 aacacttgcc gccaacacta tggcaccggt catccccgga tatatgatga ttggtgacga 403921 taaaaaagga gtcagcatgg aaaacacgca ggcgactgac ccgaaagcca ttcttcaggc 403981 agatggtttg gcggtttttg ataaggcagg atatttaaag tattggctgg aagatgatga 404041 aagcgtgggg gcagtctggc ttatgaataa gatccagcat acgtttatta atgctgactg 404101 gggcaagacg aaggatgcgg tcagcttgca ggttacccat caagatacaa agctggtacc 404161 gaaaatgcgg aacggacgcc cgtacatcca tgtgaaagtg tcggttgaag gtattataga 404221 tgctgtcaaa taccctttcc aattgtctga tcccaaggtg ctggccgcta ttgaaaaagc 404281 gctcaacaaa gagcttgaaa aggaaatcag ccatactgtg aaaaagatta agaagaataa 404341 aatagatttt atcggttttg gtgacacgat atatagaaag tatccggagc agtgggagaa 404401 aatgaaggac acttgggaca aagaatattt gccggaactg cccatcgatg tgaaggccga 404461 gacgtatatc agaaggacgg gattgcgaaa caatccgatc aaacaccagt ttaaagatga 404521 ttaggtctga agaaagggga agtgacagat ggaaaaagcc agaataagca taaggcagtt 404581 gtttgtcatg attatcattt ttgaactggg cagctcctta ttgattacac cgggatcaat 404641 ggcgggcagg gatgcttgga tagcagtttt attaggctgt gcgatcggac tgtttctttt 404701 ctatttgtat caaggcattt atcaatgtta tccgaattct tctccgaaag aatatatgga 404761 tgatatgctg ggaaccaagc tgagctggct gttttcattt ctctatatct tgtactttgc 404821 ctatattgcc gcaagggtgc tgcgtgactt tggagaaatg ctgctgacgt ttgcttatca 404881 tgatacacct atcattattg taaatgcttt attaatggta gtaagcatat atgccgtaag 404941 aaaaggaatt gaagtactcg cacgcgcggc cgaacttctt ttcggggcca tgtatttact 405001 gggcgcgatc ggccttgtgc tgattattgt ctcagggact atagacccgc acaatttaaa 405061 gccggttttg gcaaacggca tttctcctgt ccttcactct gttttcacac agaccatgta 405121 cgttccattt ggtgaagttg ttttatttgt gatgattttc cctaacctga atgacagaaa 405181 agatgtgaaa aaaatgggga tgatcgccat ggctattagc ggattgattg tggcgctcac 405241 cgtggcgatt aatattagcg tgcttgatgt tgatcttaca ctcagatccc agtttccgct 405301 tttaagcacg atccagacaa tcaaggtcga agaattttta gaccggctcg atgtcttttt 405361 tatgctggcg ctgatcatcg gcggcttctt taaggtcagc ctctacttat atgccactgt 405421 ggttgggaca tctacgctct ttaaggaaaa gaacccctct caattggctt atccgatggg 405481 attgggcatc ttaatccttt ctataacgat cgcgactaac ttttcggagc acttgaatga 405541 aggcctgaac gtggtgccgc tgtatattca tttgcctttt caattattgt ttccgctctt 405601 tctgtttatt gtggccgttt ggaaaaagaa acgaagagag aagtcaaaag gggaggaagc 405661 aaaaaaatga taaaaagagc ggggggatgc ggccgccgct ctttttatgt tcacttctat 405721 ataaaagggg gatatagggt gcgcccctgt ctgcactggc agaggcgcgt tttgttatac 405781 gactgcgacg ttttccttca cagtaaaact tcctcttgaa agtctgatat tgatgtctga 405841 cacttttgca atttgttcat cgtgcgtcac cataatgacg catttatctt ccttgtgcgc 405901 cagatcctga aagagccgta cgatctcttt tgatgtgtcc tcatcaaggt ttccggtcgg 405961 ttcatcggct acgataagat ccgtgtcaca gcagaaagcc cttgtaattg atacccgctg 406021 ctgctgtccg ccgctcagtg tgagcacttt ttgccgggct tgtttttcgt tgatgccaac 406081 cttctgcagc atgtcaagcg catatgattc tttgttcttt tctttagaac ctgtgatttc 406141 catagcggtt gtgacgttct gcaaagccgt catatacggg agcaggttgt acgcctgaaa 406201 gacgattgat acatattgat ttctgaaatt ggttaagccg attttagaaa ccgcttttcc 406261 gtcgtaaagg atgtttcctt cttttggtgc gtcaagtccg cctgccagag acaggaaagt 406321 ggttttcccc gtccctgatg ttccgacgat tgtgtagaat tttccttttt gaaagctgat 406381 gttaatatcc tgaaacaatg gctggctttt gtttttatac cagtagccga cttgttgaaa 406441 ttgtaataag ctcataggtt ccgcctcttt ctattcctgt tttgtcaata tcgttttcgg 406501 atgaagccgc agtactgaaa ttgacggcag caatgttgca atgattgcga ttaggatgcc 406561 gatcccgcca agtataagca tgtcgttcat agaaaccgcg acgttcagtg aatcgataac 406621 gtccacgttg gatgaactgt ggccgaacat tttgccgccc atgccgccac cgccgccggg 406681 catttgtccg cttgcggttt gcgttgaatc ggttgatgaa ctgatttgct gggataaaag 406741 ctgatttcca agctgattcg cgacgagatt tcccgtcaca gatgcaaggc cgatagcgat 406801 aacggccaca atcagaatct cagtcaagaa ctgtccaatc aatttccatc gtttttcacc 406861 gatggccatt aacacgccca tttcgtattt gcgctccctg attgacatca tgacaatcag 406921 gccaagaatg acggcgcctg ccactgatac aagatacacc acgtttttag agaaagaagc 406981 cacattttca atcggtccga ccatttgctg gtaaagctga tcgtttgtat tcagtgtgta 407041 cgtatcaaag tcaattgatg ttttcttcgc tgcttttacg aaagtatcca tatttttcgc 407101 gtcgtccata tagtaaacag ctgagtcaat cgtattttta tagtcgtcgc ctttcaatgc 407161 cgctgttgct gtgtaaggcg tataaagctt gttataagga tttaagaaag agaaattttg 407221 ggcttggtca tcacctgaag atgttgtttt ataaataccg acgatcttca gttttactgt 407281 tgtatcctca tccgttgctg attcaattgt gatcgaatcg ccaacgctta aatcattttc 407341 ttccgctaat gtttcgttga tcactgttac ttttttgccg acatctgatt ttgtaatcgc 407401 gcgtccgtct gtgatttttg aatctccgtc agagaaatca tcgactaacg ctgtgctgat 407461 gacaccttca atagaaagat cagcttgaac catttgcggt ccgccttgtc ctccgccttg 407521 actgttttta gcgtttgagc ttgaactgct ggagctggaa tcacttgaac tagagctttc 407581 aatcgcatca aagtttcccg cgttggctga agctgatgtg gtgtaattgt agctcttcac 407641 atgatcaagc gctgcaagct tattcgcatc agacactttg atcggtgtgg attcgaagct 407701 gcgcttttca ccgctgtcct gctgtttttc catttgcttt tggcggtcaa cctgaagtgt 407761 cacgcttcca ccgagttcct gtctggccag ttcgcttgac ttttgtgctg ccgactggat 407821 ggcgaggcct gatagaacaa agacacatat gactgtaaac acaaataatt gcaataacgt 407881 ttttcccttt ttagccttca tattccaaaa ggcccgtttg ataaagttca tttatgttcc 407941 tccgtatagg tatttttatt gataagaccg cctctggggc gcgtcccctt gctgataaat 408001 taatagtagt ccaaaggtat gaaaaaaata tgaacaatct atttctagtt gatgaaataa 408061 aaactaacaa ttgtgaaacg caaaaccttc tgtttaaaat ggtgctatta tataaaaaag 408121 catcaaaaca accggaggat ataatgaaaa tattaatgat agaagataat gttagtgtat 408181 gtacgatgac ggagatgttc ttttttaaag aaggttttga agccgaattc gttcatgacg 408241 ggttagaagg gtaccagcgt tttacggaag aaaattggga tctaatcatt ttggatatca 408301 tgcttccatc tatggacggc gtgaccatct gcagaaaaat aagagagaca agcacggtgc 408361 cgattatcat gctgactgcc aaagacactg aatcagatca ggtcatcggt tttgagatgg 408421 gggcggacga ttatgtcaca aagccgttca gcccgctgac attggttgcc cgcatcaaag 408481 ccgtcatcag aagatataag gcgacaggca aagcggttat tgatgaagat atgattgaaa 408541 cggaatgctt taccattaat aagaagacga gagaagtatt attaaacgga gagcctgtag 408601 aaaatctcac gccgaaggaa ttcgatctgc tttattacct tgtccaaaat ccgcggcagg 408661 tgttctccag agaacagctg cttgagcagg tatggggcta tcaattttat ggagatgagc 408721 gaacggttga cgttcatatc aaacggctgc ggaaaaagct tgccagcgag gacaagcctt 408781 tcctgtatac tgtgtgggga gtagggtata aatttgatga agattaaata tttatatcag 408841 ctgctgctaa gccatatcag cattttgatt ttagcgtttg tcattatcat ttctctgttt 408901 tcccactttg tgaaggaatt tgcctatcag aacaaagtag aggaattgac gtcatatgcg 408961 gtgcagattg caaatgaatt ccaatccggc caggtggaca tgcgcaggct ctatccttat 409021 caggacattt taagcacaag aaagacgcaa tttatcatct ttaatgaaga gcagcagcct 409081 tattttcttc ctgaaggctt tcatcaccca ccaagggaac agctgaagaa atcagaatgg 409141 aataagctga aaaaagggca gactgtcacg atcagggcag atggccgttt tgatgatgaa 409201 gtgtcccttg tggcgcagcc tatatttgtt cagaacgaat ttaaaggcgc cgttctgctg 409261 atttctccga tcagcggtgt tgaacagatg gtcaatcagg tcaacctcta tatgttttac 409321 gctgtgatca gcacgcttgt gattacgatt cttgtgagct ggcttctgtc caaattccat 409381 gtcaagcgga ttcaaaagct gagagaagcg acagataaag tggcttccgg cgattatgac 409441 atccatttgg aaaacagcta cggggacgaa atcggcgtac tggcgtctga ctttaatatc 409501 atggcgaaaa aactaaagca gtcaagggat gaaatcgagc gccttgagaa gcggagaagg 409561 cagtttatcg ctgacgtgtc acatgaatta aaaacaccgc tgacgacgat caacggtttg 409621 gttgaagggt tgaacagcca tacgattcct gaggataaaa aggataaatg cttctcgctg 409681 atcagtgagg aaacgaagcg catgctgcgg ctcgtaaaag aaaatctgga ttatgaaaaa 409741 atcagatccc agcaaattac cttgaacaag ctagacgttc ctctgatcga ggtgtttgaa 409801 atcgtgaaag agcacttgca gcagcaggcg gaagaaaaac aaaacaagct gatgatccaa 409861 gtagaggatc acgtcatcgt acatgccgat tatgaccggt tcattcaaat tctcgtcaac 409921 attacgaaaa acagcatcca atttacgcaa aacggtgaca tttggctgcg cggaatggaa 409981 ggttataaag agacgattat tgaaattgaa gacacgggta tcggcattcc aaaagaggat 410041 attgagcata tttgggagcg attctataaa gcagatattt caagaacgaa cacagcatac 410101 ggtgaatacg gactcggtct ctcgatcgtc aggcagctcg ttgaaatgca ccagggcaca 410161 gtagaaatca agagtgaaga agggaaaggc acaaagttca tcatccgcct tcctttaacg 410221 gcaaaacagc aatagcatac agggcggcgc atcaactgat gcatccgcct tttttgcaca 410281 ccgcttcggt ttattgcgtg ctcccgaaaa caaagattgc gtgtttttcg ggttgggacg 410341 gcctataaac atgataaaat atgacataaa cagtttttga tgggagaggg tgaaggaatg 410401 aagagtgggg taattccttc ttcagcggtc ggtcaaaaaa ttaacgagtg gtacagatat 410461 atccggacat tcagcgtgcc ggatgccgaa gtgttaaaag ctgaaatcca gcaggaactg 410521 aaacacatgc agcatgattc caacttgctg ctttattatt cactaatgga attccggcac 410581 cagcttatgc tggattatct tgagccgtta gagaaattaa atatcgaaga ccagccaagc 410641 ctgtctgaat tatcaagaaa cattgacagc aaccaggcag atctcaaagg gctgctcgac 410701 tattacgtga atttttttcg cgggatgtat gaatttgata agcgggaatt tatttctgcc 410761 attacatact ataaacaggc ggagaaaaag ctctcctttg tcgcagacca tattgaacgg 410821 gctgaattct attttaaaat cgcggaagct tattattata tgaagcaaac gtatttttca 410881 ttgattaata taaaaaacgc ctatgaaatt tacgtggagc aggaaaccta taatgtgaga 410941 atcattcagt gccatttcgt cttcggggtc aacctgatgg atgaaagaaa tttcgaacaa 411001 gccgcacgcc atttcaaatt ggcgctcaac atggcccaag cagaacaaaa agcccagctg 411061 gttggaagag catactacaa tctcgggtta tgctattaca atcaagacct tctagaccct 411121 gccattgatt actttgaaaa agcggtctcc acatttgaaa gcagcaggat cgtcaattct 411181 ctcccgcaag cctatttttt aatcaccctg atttattata aacagggaaa acatgataaa 411241 gcttcggaat atcacaagcg gggctatgaa tatgctaaag aaacagacga tgcagactat 411301 gccgtaaaat tcgagttttt gcaatcccta tatctggatc agcccaatga agaaggaatc 411361 gaacgatgtt tccagtactt aaaaaataaa aatatgtacg ctgatataga ggatttagcc 411421 ctagaagtag caaaatatta ctatgaacag aaatggttta aactgtctgc ttcctacttt 411481 ctacaagttg aagaggcaag aaaacaaata caaaggagtg aaggtttgta tgaaattgaa 411541 atctaagttg tttgttattt gtttggccgc agccgcgatt tttacagcgg ctggcgtttc 411601 tgctaatgcg gaagcactcg actttcatgt gacagaaaga ggaatgacgt aagaacaagc 411661 cccttctcat tagcgagaag gggtttttct tttcaaaaaa acaccgcaag acatagtctt 411721 gcggtgccgc cttcatggag attacgttta tttagtagcc tcctacaaat gcagttccca 411781 caatgatcaa gaggataaat aacacaacaa tcaaagcgaa agaagttccg taacctgaca 411841 ttttgtgcac ctccttgcga gattgcttca gcaaatgctg caaaactgtg gcggacaggg 411901 tcccgcagag acggtcagca gcttagaagc cgccaacaaa cgcagtccct acgataatta 411961 atagaataaa caatacaacg attaaagcga aagaactgat gccgccgtaa ccgccgccgt 412021 tagagtatcc tgacataagg tttcacctcc ctatgaagga tactataaga tatgctgaac 412081 cgatccattt ggcagggata atagtggaca agagaaaaaa tgaagaattc ggctatatga 412141 aggtgatata aaaaaatagc gggcgctgcc gcccgctatt tatgtacgat taagagatca 412201 gcacgcccgc gaaaaattcc tggtataacg cttgaacggc ttttctttct tcggcttctt 412261 ttacgccaaa catcatgctc acttcagaag acccctgatt gatcatttcg atattcacct 412321 gtgcctctga taatgctttg gcggctcttg ccgttgtacc gacattgtgg cgcatcgctt 412381 cccctacaac cataatcagg gcgagatgat gctcgacgat gacttcatcg gcatgcaaat 412441 cctcttcgat ccgtttgatg acgctgcgtt cagtggcggc atccatttgc ccctgccgta 412501 aaatgattgt catgtcatcg attcccgatg gaacatgctc atacgtcaaa ccatgctcct 412561 ccaggatttg aagggctctg cggccaaaac cgatttctct gttcatgaga tacttgctga 412621 tataaatgct gcaaaaaccg gtgtcgctgg caatgccgac gacaggcccg tttgtgttat 412681 cccgcttgct gacgacgcgg gtgccttcgg ctgaggggtt gttcgtattt ttgatctgaa 412741 caggaatccc cgctctgaat gccggaatga gcgcttcatc atgaaacact gaaaaacccg 412801 cgtaggacag ctcccgcatc tctctatatg tcagctcgct gatttccttt ggattctcaa 412861 cgaaggacgg attgacagaa tacacagcgt ctacgtctgt aaagttttcg tacaaatcgg 412921 cttgtagtcc gttggcaaga atcgaaccgg taatatcaga accgctccgt gagaatgtga 412981 tcacatcgcc atccttgctg aatccgaaaa aaccgggaaa aatgatgagt ccgtcacgtt 413041 cccgaagacg atagaggttt tgataggatt caggaagaac ttgcgcgttg ccgggttcat 413101 ttgtcacaaa gaggccggca tccttcgggt ttacatattc cgctttgacg cctttataac 413161 ggaagtaagc ggcgatcagt ttggcattgt tatcctctcc gctggccttg actgcgtcaa 413221 ggtattgttc gggattgctt ttgtctcctt ctaaaagcgt aaacagatca tctctgattt 413281 tttcgataat gctttgcccc agctgaagct cattggcgat gagagcgtac cgttccacaa 413341 cagcttccgc cagttcaggt gcgctgcctg ttgccaaata ttgttctgca catgcgatta 413401 agagatcagt cactttcgta tcctcggcat agtgttttcc cggagctgaa acgactacag 413461 ctttccgtgc cggatctgag gtaacgatgt gaaacacctt gtcaagctgg gcgcctgaag 413521 caagtgagct gcctccgaat ttaacgacct tcatgtttac atctcctaat gtttaaaatt 413581 ttcacacaaa tttagtattt attatctctc tttcagtact gtaaatcaag ggggaatttc 413641 tttctcagga gaacatttgt atttttcacg aggaataatg ttaggtttgc tgaccgtatg 413701 cctgcgttat aaagataaat atggtaaaca gcctaacgtt ttgggatgga aaatggttag 413761 aatgattagt aaaattgata aatgactagg ttaatatttt taaagaatat tgactaaccc 413821 tataaaaatg gtaatatgta aatgataatg ataatcaatt actatatggc catattgttt 413881 tgagtccttg cggagtagga gatacgttct ttttgctgta aggatgtaag gaggcagcat 413941 gaagctacgt tacttattta ttctacttat catattagca gtcacatctg tatttatcgg 414001 tgtagaagat ctgtcgccgc ttgatctctt cgatttaagc aaacaagagg cgtcaacgct 414061 gtttgcaagc cgtttgccgc gattgatcag cattgtcatt gcgggattaa gcatgagcat 414121 ctgcggtttg attatgcagc agatcagcag aaataaattc gtgtcaccga cgacggcggg 414181 cacgatggat tgggcgaggc tcggcatttt aatttccttg ctgctgttta catccgccag 414241 tcctttaatc aaaatgctgg tcgcgtttgt ctttgccctt gcaggaaatt ttctgtttat 414301 gaaaatcctt gaaagaatca agtttaacga caccatcttt attccgcttg tcggtttaat 414361 gctcgggaat atcgtcagtt caatcgcgac atttatcgca tataaatatg acttgatcca 414421 gaatgtgtca tcatggctgc agggagactt ctctttagtc gtgaaaggaa gatacgagct 414481 tctttatctg agtattccgc tcgtcatcat tgcctatgtg tatgcggata aattcacatt 414541 ggccggtatg ggtgaaagct tttctgtcaa cctcggcctc aagtataaac gggttgtgaa 414601 catcgggctc attatcgtgt ccctgatcac gtctcttgtc attttgactg tcggtatgct 414661 gccgtttctc ggtttaatca tcccgaatat tgtatcgatt tacagaggag acaatctgaa 414721 gagcagcctg ccgcatactg tgctgttggg agcggttttt gtgctgtttt gcgatatact 414781 gggcagaatc attatcttcc cttatgaaat ctcgattggc ctgatggtcg gaatcatcgg 414841 cagcggcatt ttcctgttta tgctgttaag gagaaaagcc tatgcgtaac cagatgaaaa 414901 tagctttgct cgttggttta gccattgtat gtattggctt gtttttgttt tatgacttag 414961 gcaattggga ttacaccctg ccgagacgaa tcaaaaaagt cgctgccatt gtgctgactg 415021 ggggagcgat tgcgttttcg accatgatct ttcaaacgat tacgaacaac cgcatcctga 415081 cgccgagcat tttgggcctt gattctctct acatgctgat tcagactggc attatctttt 415141 tgttcggttc tgcgaatatg gtcatcatga ataaaaacat caactttatc atctctgttc 415201 tgctgatgat cctgttttct cttgttttgt atcagatcat gttcaagggt gaggggagaa 415261 atatcttttt ccttctgctt atcggaatcg tgtttggcac gctgttcagc agcctgtctt 415321 cttttatgca gatgctgatt gatccgaacg agttccaagt tgtgcaggac aagatgtttg 415381 ccagctttaa caatatcaat acggatttgt tatggctcgc gttcatcatc ttcctgctga 415441 caggcgttta tgtctggcgt tttacaaaat ttttcgatgt gctgtcgctc ggacgcgagc 415501 acgccgtgaa tttgggcatt gactacgaca aagtggtgaa gcagatgctg atcgtggttg 415561 cgattttggt ttctgtttca acagcgctag tcgggccgat tatgttttta ggccttctgg 415621 tcgtcaacct ggcgagagaa ttcctgaaaa catataagca ttcatactta atcgcaggct 415681 ccgttttcat cagcatcatt gcgctggtcg gagggcagtt tgtggttgag aaagtgttta 415741 ccttctcaac gacgctgagc gtcattatta attttgccgg cgggatttat tttatctact 415801 tgctgttaaa ggagaataaa tcatggtaga ggtcagaaat gtaagcaaac aatatggcgg 415861 gaaagttgtt cttgaagaga cgtcagtcac gattcaaaag ggcaaaatca cctcgtttat 415921 cggtcctaac ggcgccggca aaagtacgct gctgtctatc atgagccgcc tgatcaaaaa 415981 ggattccggc gagatttaca tagacggaca agagattgga gcatgtgaca gcaaagagct 416041 tgccaagaaa atgagcattt tgaagcaggc gaaccaaatc aatatcaggc tcacgatcaa 416101 agacctcgtc agttttggca ggtttccgta ctcacagggc cggctgacag aggaagactg 416161 ggttcatatc aaccaggcgc ttagctatat gaagctggaa gacattcaag acaaatactt 416221 ggatcagctg agcggcggac agtgccaaag ggcatttatc gccatggtca ttgcccagga 416281 cacagattat atctttctgg atgaaccgct gaacaatctg gatatgaaac actcagttga 416341 aattatgaaa ctgctgaaac ggctggtaga ggagcttgga aaaacgatcg tgatcgtcat 416401 tcacgatatc aattttgctt cagtctattc tgactatatc gtcgctttga aaaacggccg 416461 aatcgttaaa gaaggaccgc ctgaagaaat gatagaaaca tcagtgcttg aggaaatcta 416521 cgatatgacc atcccgattc agacgattga taatcaaaga ataggtgttt atttttctta 416581 atatatagaa gaggtgagga gcatgaaaaa gttcgcgtta ctattcatcg ctttggtcac 416641 tgccgttgtc atttctgcat gcggaaacca aagcacaagc agcaaaggtt ctgatacaaa 416701 gaaagaacaa atcacagtga aacaccagct cgacaaaaac ggcacaaaag taccgaagaa 416761 ccctaaaaaa gttgtcgtat ttgactttgg aagcttagat acattagata aactaggact 416821 tgatgatata gtagcgggcc tgccgaaaca agtccttcct aaatatctgt ccaaattcaa 416881 ggatgacaaa tacgctgatg tcggcagctt aaaagagcca gacttcgaca aagtggcaga 416941 attagatcct gatctgatca ttatttcagc aagacaatct gagtcttaca aagaattctc 417001 taaaattgcg ccgacgattt accttggtgt agatacagcg aagtacatgg aatcatttaa 417061 atcagacgct gaaacaatcg gtaaaatctt tgataaagaa gacaaagtga aagatgagct 417121 cgcaaacatt gatcactcaa tcgcagatgt aaagaaaacc gctgaaaagc ttaacaaaaa 417181 cggtctcgtc atcatggcga acgatggaaa aatcagcgcg ttcggcccta aatcaagata 417241 cggcctgatc catgacgtat tcggcgtggc tccggctgat caaaacatca aagcgtctac 417301 gcacggacaa agtgtttctt acgagtacat ttcaaaaaca aaccctgatt acttgtttgt 417361 tattgaccgc ggtacagcaa tcggagaaac atcatctaca aaacaagtcg tggaaaacga 417421 ttatgtgaaa aacgtaaacg cagtgaaaaa tggtcatgtc atctaccttg attctgctac 417481 ttggtattta tcaggaggcg gacttgagtc tatgacgcaa atgattaaag aagtgaaaga 417541 cggtttagaa aagtaaaacc aaaaagagcc tccgctaaat agcggggctc tttttttgtt 417601 aatcagcgtg ccggctgctg ttcggcaggg cgctgaggtt tctttaatgt gaatgagaga 417661 aggaagccga caagtgcaat gacggcagcc actataaaag cggcgttcat gccgtgcagg 417721 gcggcgtgct tcacatttgt cgtgcctgca tgtgccgcct ggttgctcat cacggaaacc 417781 aatagtgcgg ttccgatcga gccgccgact tggcgaatcg tgttgttcat cgcagttccg 417841 tgcggaatca agtggcgcgg cagcgcattg attccggctg ttgtcaccgg catcatgatc 417901 atggcggtgc ctaagagacg aacggtgtat aaaacgacaa tccaagcgag tgacgtatgg 417961 tcagtcagct gcataaacgg cagagatgtc aggaagatga tgcagaaacc ggcaatcgcc 418021 agccctcttc cgccgacacg gtcaaaaatt ctgccgataa tcggcgacat aaagcccatc 418081 acaacggctc ccggcaggag cataagccct gtatcaaaag ctgtgacgtc tctgacattt 418141 tgtgtataaa gcggcaggat ggtttccgta ccgatcaata atgcaaagac gagggttccc 418201 agcagtgttg ttaagctgaa aacgccaaac gtgaagacgc ggaattccag catcggtttt 418261 ttaagcttca tttgtcttgt gataaacaag agcagcgcga tgacacccac cagcagtgaa 418321 atcaagacgg ttgaactgga ccagccataa gagccgacgc ttgagaagcc gtacagaagg 418381 ccgccgaacc caaatgttga aaggatgact gataaaatat caatctgtgt ttttcttaaa 418441 gtcgtcacgt ttttcatcag gatgctggca agaatcaaat caatcacagc aaacggaaga 418501 ataatataaa acaatgatct ccaagagaaa gcttcgacag cccatccgga aagagtcggt 418561 ccgatcgcag gcgcgaatga gatgaccaat ccgaccatac ccatagcctg gccgcgcttt 418621 tcaatcggaa agattgtcag gaatacagtc tgcatgagcg gcatcataat gccggctcca 418681 gccgcttgaa tgatacgcgc tgtcagcaga accgggaagt tcggcgcgaa cgctccgacg 418741 actgttccgg cagtgaaaat gctcattgct gtgatgagca gcgcccggct tgtgaatttc 418801 tcaattaaaa acgcggtaat cggaattaaa atcccgttgg ttaacataaa tgatgttgtc 418861 agccattgtg cttggttggc atcgacattg aaatccctca tgatatgggg aagtgcagta 418921 atcaacaatg tctggttcaa aatcgccaca aacgctccgg ctaacaaaat gccgacaatg 418981 acagaacggt taaaaggttt ttgttcaata cttgtgttca atacatatcc cttcttttct 419041 ctaagtaatt aacagtgttt ttaacatgga aacgggctgt gttaaaacac cggtttgttc 419101 cagatagcca atcagtgatt tgagtaaaaa agcgcggggt tcttccttct tcgcttcttc 419161 ctccagcata gcggctgcgg atgtcagttc atctacgtca tagtccgcgg cggacaggga 419221 agagatgcct ttatgtaatt ccttcaggct ttccgataat aggactgatt tatcctttgg 419281 cttgtaggag gatgctgaat gaatataaag ctcgatggct tcgggcggaa gaagagactg 419341 gcgggtttcc ctgtttttga taatctgatt gagggtgctg atgataaact ctgcgatcgg 419401 gtcaagctca agcggttttt cctcgatttt gatcagcatt aaaaactcac gcatcatgcc 419461 gtgaagaatg ataaccaaat cccacacaaa cgggagaatg gtttctccat acgcctggat 419521 cagcgaatcg cggtgccagc agataatcgt cgatctggtc tgatggatat gctgtttgac 419581 ccggtcattg tgcagcttgg ggtttccgta ggtcagcata ttgaaaaact gctgattccg 419641 cctgaagccc tccagttcca ttttgacctt ttgcgtcaaa cgctcctccg gtgtaagtgc 419701 tgtattttcc tgaagtcttg aggccgcggc caccatttgc ttctggttaa atgacagcag 419761 ctccaaaagc agatcttctt tagattggaa cagcttatat atcgaagctt ttgacatctt 419821 acattcttct gcgatcgcct gcatggaaac cgacgtaaaa tccttttccg aaaaaagctt 419881 tcgcgcggct aacaagatat ctgttttttt atcaagcatc tcatggcttc cttctttctt 419941 gaacattaga aaacccattg gttcacagaa aaccaatgag taacaatgaa aaaattttac 420001 cagataaaca aaatagaagt caatggattt taaccgggta aatgaaaggc ctgccggaaa 420061 atccgacagg ccgaataaga gcttattttt caactttaaa tccttgtttt tcaagcattt 420121 cacggatgtg cggatagtac aggcgctcat agtaggaagc gatgctctgt gaccagtttc 420181 ttgtttcttt tccgtttgtc cgtttattca tgtattcaga catctgttcg tcgtatgcct 420241 gaatgtgaga cgtcagctca tcctgattca aataagtttc ctgatgattg acagcttcct 420301 gcggcaagcg cggttttttc gctgaacggt cggcaggatg cccaatgaca aggccggata 420361 aagggaacac gtatttcgga agctcaagca gttcgatcag ctcttgaggg tttccgcgaa 420421 ctgcaccgat cggaactgtg ccaagtccga gtgactcagc cgctgctgtt gctgtgccga 420481 gggcaatacc agcgtctact gcgccgacaa gaacagattc caatccattt gtgatttcca 420541 ttttgaaatc atgcagatct tcaagcgcaa ttttggcccg gttaaaatct gcgcagaaca 420601 gcaggaaaac aggagcttga tcgatccatg gctggccgcc tgccagctcg gagattttct 420661 ttttgcgctc tttatcctgg actgtgatca cagtcacttg ctgtccgttg atagaagaag 420721 gggctgattg caccgcttca atgatttggt ccaattgctc ctgagctaca ggctcatctg 420781 tgtagctgcg aatcgagcgg tggtctgtta aagatttaat cacttcattc atatgagaca 420841 cccttccttt actcgctaag ctctgtgcgg acaacatcaa gaggagcgct cagcagttct 420901 tttccttttg cgacaaaccc ttggaaatgc gcagtttcgt tatggaattt cattgccgct 420961 tcatctttcc atttttcaag catgacaaat gtattttctt cgcctacttt ttcgaatagg 421021 tcgtattgcg cgttgccttc ctcagctctt gaatgctgaa caagtgattg agcctcgctc 421081 aaaaattcct cgcgtttttc tggttttact ttgatgtaag cttgtaatac gatcatgtaa 421141 atctcctccg tcgttatgcg aatttattgt tcgaatttca tcgaactaaa tgtaacatgt 421201 attctaaatg aggtaaagga aaaaccctta tatagtaaaa ttgtcattct aattgttgta 421261 tgatacattt gtgtcatgaa cattccaaac catccagaaa cagaaacatt gcagctgaca 421321 aaggttcttc atgcacttag tgatccgctt cgtttagagc tcgtcaagca attagctgaa 421381 gcaaaagaaa aaacgtgcag cacctgtgca gatgtgcagg ttgccaaatc gactttgtcg 421441 catcatttta aagttttgag agaatcaggc atcgctcaag ttcggataga aggaaagcgc 421501 cggtattatt cgcttcgcgc tgaagacctt gaaaaggcat ttccgggact gcttgaagcc 421561 gtgctgaatg tagaccagga ccgctggtga atcaatcccc tgtaacgggg atttttttat 421621 gtccgtaaac cgctttgaaa agccgctgca caccctcctg aatatcttct tccttcagcc 421681 gtgcaaagcc gataatgaga gcaggcctgc ccgtttgccg cttgttttcc ttcaagttaa 421741 atcggctcat tccgaatatt tcaagctgca gcccggcagc atgtgacagg atgtcttgtt 421801 cggtgcgcct ggtatcaaat tcggtaacaa aatgcagccc cgcatttgcc ccttttacgg 421861 taacctctcc gctgaactct gcttctaaag cggtgatcag gcgttctctc ttttctttat 421921 aatgctgctt catttttttt atatgcttct gatattcacc agactcgata aattcctgca 421981 gggtgagctg tgtgagtgat gagcaagtct gcagatcata gccccgctgt ttgtatgccc 422041 tcaacagctc aggcggcaac accatatagc tgatccgtaa gccggggaga agggactttg 422101 aaaaggttcc catatagatg acattttgaa aacggtcgag gctttgcagc gccggaatac 422161 tgtctacatc atatgtgaat tcactatcat aatcgtcctc aatgatatat cggcgcggct 422221 cctcggctgc ccagttcagc agctgaattc ttctggatac aggcataatc gttccggacg 422281 gaaactgatg cgacggggtg gtcaccagca catctggctg ctgtctggtg atttcagcaa 422341 tcgacatgcc tttttcatcc agcatgatcg tctttacttg ttttccggca ttcttcaaaa 422401 gctgatacat gcgcctgtag ccaggctcct ccatcgcata cacggcttcc ttgggtaaaa 422461 gctcagtcaa cagctgcatg agcacctgtg tgcctgcccc tatgatcatt tgttccggcc 422521 tgcattttac acccctcgtc agggaaatga gcctcgtaat ggccgctctc acttcatata 422581 tcccttgcgg atgtgacata tcgccgagcg tgcggtatga gcgggaggcc gctttttgct 422641 cgcagcggaa ccagcttttg atcggaaaat ggtctgtatc ggaactcatg tgtgaaaacg 422701 atatccaatc gctctggtcg atgtgaatct cttttaggtc atccggcagt gcaaatggag 422761 ggtgctcctc ggcggaaaac atgtctagtt cctccacgaa gaaacccttt cgttcaatgg 422821 cgtacaaata cccctcagcc agcagctgct gataggctga attcactgaa tttacgctga 422881 ccttgagatt ttcagccagc tcccgcttgg agggaacctt cgagtgcggc agcagattgc 422941 ggctgaggat ttcttttttc agcttttgat aaatttgctg atagatataa tcggcttgtt 423001 ctgaacgatc gagtgtaatc gtgatatcca ttttgtagtt tctccttctg ataccatcaa 423061 aaagttataa ttggtacttt tcatcatacc aaagagaagt cagaatgata agaaaatacc 423121 gacaggggga tattcacatg agtcaaacaa cagcaagcat cacaactgca caatggcagc 423181 aaaaacggga tcaatttgtg tcaaaaggtg tgagcaacgg caaccgcagt ctggcggtca 423241 aaggagaagg ggccgagctg tacgatctgg atggccggag atttattgat tttgcaggcg 423301 ccatcggcac gttaaatgtc ggacactcgc atccgaaggt ggttgaggct gtgaagcggc 423361 aggcggagga gctgattcat cctggtttta atgtcatgat gtacccgact tatatcgaat 423421 tagcagaaaa actgtgcggc atcgcgccgg gcagccatga gaaaaaagcg atttttctta 423481 actcaggggc agaagcggtc gaaaacgctg tgaaaatcgc cagaaagtat acaaagcgcc 423541 aaggcgttgt ctcgtttaca cgcgggtttc acgggcgcac gaatatgacg atgagcatga 423601 caagcaaggt aaaaccttat aaattcggtt tcgggccttt tgcgccagag gtttatcaag 423661 cgccgttccc ttattattat cagaagccgg ccggcatgag tgatgaaagc tatgacgata 423721 tggtcattca agcattcaat gatttcttta tcgcttcagt ggcgcctgaa acggtggcgt 423781 gtgtcgtgat ggagccagtg cagggagaag gcggatttat tattccttcg aaacggttcg 423841 tacagcacgt cgcttcattc tgcaaagaac acggcattgt ttttgttgct gatgaaatcc 423901 aaaccggctt tgccagaact ggcacttatt tcgcaattga gcactttgat gtagtgcccg 423961 atctgatcac ggtttctaaa tcgcttgcgg caggcctgcc attaagcggt gtgatcgggc 424021 gtgcggaaat gcttgatgcg gcagcgccag gggagctggg cggcacgtat gccggcagcc 424081 cgctcggctg cgcggcggct ttggcagtct tggatattat cgaagaagaa ggactgaatg 424141 agcgatctga agaaattggc aaaatcattg aagacaaggc gtatgagtgg aaacaagaat 424201 tcccgttcat cggtgacatc cgcagactcg gggcgatggc cgcaatcgaa atcgtcaagg 424261 atcctgacac gcgtgagcct gataagacaa aagcagcagc gatcgcggcc tatgcgaatc 424321 aaaacggatt acttttgctg acagcgggaa ttaacggtaa tatcatccgc tttttgacac 424381 cgctcgtcat ctcagacagc ctattaaatg aagggctcag catcttggag gcgggcctgc 424441 gagcttaatc attggaaaga aaatggccgg gtctgctatc attttaagta atcatgaaaa 424501 gaaaggaatg ttcaatatgc cagatcaatt aacggtctac aacccggcta cgggcgagga 424561 gatcaaaacg attcctcagc aatcagccac agaggtagaa gaagccattg aacgttcaca 424621 tcaagcgttt aaaacgtggt ctaaaacatc agcgaacgaa agaacgtctc ttttgaaaaa 424681 atggtatgag ctgattgttg aacataaaga agagcttgca gatttaatta caaaggaaaa 424741 cggaaaacca taccaggaag cagtcggcga ggtactttac ggcgcaggct atatcgaatg 424801 gttcgcagag gaagcgaagc gtgtgtacgg aagaacggtc ccggccccga caactggtaa 424861 acgaattgtt gtcacacgcc agccggtcgg ccccgttgct gctatcacgc cctggaattt 424921 cccgaatgcg atgattacac gcaaagcggc gcctgctctt gccgccggct gtacatttat 424981 catcaagccg gcgccggaca caccgctgtc tgcttatgaa ctagcgcgcc tcgcatatga 425041 agcgggcatt ccgaaggatg ttcttcaggt tgtgatcggc gatggagaag aaatcggaaa 425101 tgtgttcaca agcagtccga aaatccgcaa aatcacgttc acaggctcaa cacctgtagg 425161 gaaaatcctt atgaaaaaca gcgctgacac cgtaaagcac gtctcaatgg agctcggcgg 425221 acacgccccg ctgatcgtag atgaagatgc ggacattgac cttgccgttg aacaggcgat 425281 ggcgtccaaa taccgaaacg ccggccaaac ctgcgtatgt gccaaccgcc tgatcgttca 425341 tgaatccatt aaagatgaat ttgctgcgaa actgagcgag caagtgtcta agctgaaagt 425401 cggaaatgga cttgaggaag gcgtcaatgt cggcccgatt atcaacaaac gaggcttcga 425461 aaaaatcgtc agccaaatag atgatgcggt tgaaaaaggc gcgaaagtga ttgctggggg 425521 cacatatgac cgaaacgatg acaaagggtg ctactttgtg aatccgacag tgctcaccga 425581 tgtcgatacg tccatgaaca tcatgcatga ggaaacattc ggcccggtcg ccccgatcgt 425641 cacgttttct gatattgatg aagcgattca gcttgccaac gatacaccgt atggcttggc 425701 tgcttacttc ttcacagaaa actaccgccg cggcatctat atttccgaga atctagagta 425761 tggcattatc ggctggaatg acggcggacc gtcagcggtt caagcgccat tcggcggaat 425821 gaaagaaagc ggcatcggcc gtgaaggcgg ttcagaaggt atcgagccgt accttgaaac 425881 aaaatatttg tccatcggtt tataaaagaa tgcacgctcc tgagagctgc cggattttcc 425941 ggcagctctt tttgtgttcc ggcgaataat cacaacaatt ccagccaaaa taacagcaaa 426001 tacattttga aagaaggttc cccaacaatg gatttattat tggctcttct cccggctttg 426061 ttttggggga gcattgttct cttcaatgtg aaattaggcg gcgggccgta cagccagaca 426121 ctgggaacga cgatcggggc actcattgtt tctatcgtta tttacttttt tgttcagccc 426181 gttctgtccc ttcgcatttt tattgttgga atcgtatccg gcttattttg gtcacttgga 426241 caggccaacc agttgaaaag cattcaattg atgggcgtgt cgaaaacaat gccgatttcc 426301 acaggaatgc agctcgtttc cacctcgctg ttcggtgtga tcgtgttccg cgaatggtca 426361 acaccgattg cgattacgct tggcgttctc gctttgatct ttatcattgt gggaatcatt 426421 ctcacgtcct tggaagataa gaatgataaa aaagagggcg agccaagcaa tttgaaaaag 426481 ggcattttga ttctccttgt ttcgactctt ggttatttgg tttatgtagt cgtggctaga 426541 ttattcaatg tgtccggctg gtccgcgctg ctgccacagg caattggcat ggtggtcggg 426601 gggttagttt taacctatag acacaaaccc tttaacaagt atgcgatcag aaatattctc 426661 ccagggttaa tctgggcagg cggaaatatg tttttgttta tttctcagcc gcgagtcggc 426721 gttgcaacga gcttttccct ttcacaaatg ggaattgtca tttctacgct cggcggtatt 426781 ttcatcctgc gtgaaaagaa aacgaaacgc cagctaatag caattgcgat cgggattatc 426841 ctgattattg ccgccgccgt attcttagga atcgccaaaa caaattcata acaaatggag 426901 gaggatgtat atgtatccgg atttaaaagg aaaagtcgtc gctattacag gagctgcttc 426961 agggctcgga aaggcgatgg ccattcgctt cggcaaggag caggcaaaag tggttatcaa 427021 ctattatagt aataaacaag atccgaacga ggtaaaagaa gaggtcatca aggcgggcgg 427081 tgaagctgtt gtcgtccaag gagatgtcac gaaagaggaa gatgtaaaaa atatcgtgca 427141 aacggcaatt aaggagttcg gcacactcga tattatgatt aataatgccg gtcttgaaaa 427201 tcctgtgcca tctcacgaaa tgccgctcaa ggattgggat aaagtcatcg gcacgaactt 427261 aacgggtgcc tttttaggaa gccgtgaagc gattaaatat ttcgtagaaa acgatatcaa 427321 gggaaatgtc attaacatgt ccagtgtgca cgaagtgatt ccttggccgt tatttgtcca 427381 ctatgcggca agtaaaggcg ggataaagct gatgacagaa acattagcgt tggaatacgc 427441 gccgaagggc attcgcgtca ataatattgg gccaggtgcg atcaacacgc caatcaatgc 427501 tgaaaaattc gctgacccta aacagaaagc tgatgtagaa agcatgattc caatgggata 427561 tatcggcgaa ccggaggaga tcgccgcagt agcagcctgg cttgcttcga aggaagccag 427621 ctacgtcaca ggcatcacgt tattcgcgga cggcggtatg acacaatatc cttcattcca 427681 ggcaggccgc ggttaaacat aaaaagcgac ccagacatga catctggatc gctttcttta 427741 ttaggcacgc tttttcttta caagtgctgc tacagataaa ataatggcag ccgcagacag 427801 caccatcgct gtaatgtcta gagctgaaga acctgagttt tcggaatcgt cttctgtttt 427861 cgtggcgccg tgctcatctg tcacttgctt tgcagacgtg atgtttgtaa tggaatgagg 427921 tgtatcggca tcctcgtcac ctgtccactc aacaatgctg ccgtctttgt aatattggta 427981 tgcgtcccaa gcagcttcct ccgctttgtc agggtttttg gcaacaaagg taaactgctg 428041 gaactggcct tcctgaatgc ctccgtcagt cgcctcccat gtcacggata ctgatttgtc 428101 atcatgtttt tgagtggaaa ccttccagcc cggaattggc tcatattgct ggaattcaac 428161 atccttcggc attttgagga caaccttcgt tgtcggcaga tttttctcag aaggaacctt 428221 cattgtatac gtttcccaag agcctgcagc agactcagcc ggttttacag aaacatgcgc 428281 gctggcaggg gccgtaaaga ataagaggga gccgacaata gccggacata gtgtcaatgc 428341 gatttttttc aacaacgtaa acactcctta attggtcttt gtaaacatga tattgatttc 428401 gttaaagtcg ccggtcaggc cgtggacttt gatcttccag tttccttttt cattaatcga 428461 caggttttga tcttggaaga cgccttttgt tttttctttt aatgtaaagg tgcttttgtt 428521 ttcgctgcct gacaggcctg ttttataaac ggttaacgtg atttgctgga tgtttttcac 428581 gggatcaccg ttatggtcgg tgacccgcag ctcaaaaaca ttttttccag gctggtttgg 428641 gctgatgctg agagaaacgc tttgtccgtt ctctatcgct ttggtttggt agaacggttc 428701 cggcgctggc tcaggcgggc ttggcaggct tgtaaacacg gccgctgtga tcaatacagc 428761 gatgccgatt gcccactccg ctttcaacgt tcggctgatt cctgtgcggc gctgctttct 428821 ggtaagcaga aaatgaattg cgcctaagac cagcatgaaa acaaacagcc cgcttttcac 428881 taaaagagct tgtccgtacg ctgtatggaa cagtgaatcc attgaacgaa tgatgaaaaa 428941 tccattgagc aagcctgaaa acaaaatgac gccgactgca gtgagcgccc atggggagaa 429001 ccgtctgacc gtctcccacg cgagcgtttt gtcaggctgc ctccattctt ttgagagcag 429061 caaaacgagt gccgctattc cgccgaccca gatggaagcg gaagttaaat gaaggaaatc 429121 catcaaaatg ccgaccgttt tttcttcaac gacagcagca tgcccggtaa acgccttggc 429181 aagcaggaga ccgaaaaaga aaatgagcgg cgctgtccaa tagccaaagg atgaaaagcg 429241 gtttttccgt atcgcaggga tgacagacag tgcgagcagc acgaacagcg cagcctgtat 429301 gatccaaatg gagccgcctg ctgtctcaaa cagtgtttct ctgatgtagc ccggctggaa 429361 tgcgctgccc cagccgccgc ctgcgttcgc ttttgtctga atcggaagct gaagcaaaag 429421 cgccagcccc aatgctgcga tcgagccggt caggatacgt ctcgtccgtt tgacgagctg 429481 ttctgatttc cctttatacc agaaaagatg gaagaaaacc gttccgataa acagagataa 429541 ggctgtatac agaatcgcgc gatctgctgc tgttcccgga ttcagcgctg aatcggctgc 429601 tttttggctg ctgaatccgc catccgcttt cccgatactg aacggaatga cgccggaaac 429661 aggatgtcca tccgcggata cggcattcca ttccgctctg tacacatctt taggcagatt 429721 cttcttcagc ttcactgtca tgatgtgatg attatctttt ttgatttcag tcttgtccgt 429781 atccacacgg tcgccgtttg aattatagac tttaatgtaa tgaaaccctt cttcaaccgg 429841 ttcattaaat tcgatttcca cctgcgcagg ggcgcttttt aattcgctgt tttccccagg 429901 tgaagatttg acaatatagg cgtgagcaaa gcttgttttc ggcaggaaaa caagaaaaag 429961 cagaaggatg atccaccatc tgtttcgctt catcactcag acaccacctt ccgctgtatg 430021 tgttgtgtta tttcttggtg caggtgcagc gtttctttcg gtcttgaagc atgtcttcca 430081 gcgcttggtc gaaagtgcag acggctccgc cgaatccttt ttgaaatcgt tcggcatggt 430141 caagtgtcgc aaacggaatg gcctgcggct ggcagcagtg caggtttaat tcagcattta 430201 cgacgaaata agccgaaccg gcactgacgg ttgtctgtaa cagaaaatct ctgcaaatca 430261 agtgtgaaac ctcttccgtt ttatccgcgt aacgcaaaaa cgcgcaatgt gcgcagcata 430321 gctgttcaat gtcttggttt accgtaatca gctgaaccga atgagcttga ttgacgggct 430381 tcaagcaata gctgcacata tgatctgttt gaggtgttcg gacggggagc gtgatgccgc 430441 cggccgtttt aatgacctga tttgactgaa ccagctgatt gacatctcta tataccgtca 430501 tttccgaaac gccgaacctt gcgctgatgt cagaaattct aagcgagcct tcttctttca 430561 gccacttcag tatgtgttgc tgtctattaa tcggaagcat tcatacaccc tcttcattaa 430621 gatctattta agcgtagagg attttagaga cggagacaag taagtggatg ataaaaaatg 430681 tgaaaatgtg ttgaacagca acaaaacgaa acagaaggga ctctggtata atagacagat 430741 ggaatagaaa gtgaggaata ccctatgaaa gaaacaccat gcccgaactg cggcaaacct 430801 ttgacaggcg atatggtcag atcatcaaat gtgccttgtc aatttcgctg cggccactgc 430861 cgggaacggc tttatgaata taaagtttca gctccgatta tgctggtatc attagcggcc 430921 atcgtgctgc ttatttatct tttgatgctc ctccgcaatg cggcaggctc agtgctgcca 430981 gctgtacagc acgtgccgat ggctgtattt gcgcttgtgt gcgcgtatcc cgtttttatt 431041 gtgagtgagc ggatgattgc aaagtacgtg attcaaaatg gcaacatcat ttatagagga 431101 aagagaaaag gctcctgaaa ccaggagcct ttttattttt aaaaaattgt cacagtcatg 431161 tgccaaagtc ctctttactt tcaattgtat agggactgta agcgttttaa catagagtca 431221 aagggaagca tcattctctg aacatatttt tgtatcttac agcgacaaac aaaacaggga 431281 gggtttatat atgcagcagc aagaacagca gcaaggcggc atgaaagtga aagtgcaacg 431341 ctttgggagt tatttgagcg gaatgatcat gccgaatatc ggcgcgttta tcgcgtgggg 431401 tatcattacc gcgctgttta ttccggcagg atggtttccg aatgaacagc tgaacacgct 431461 ggtcagcccg atgattacgt atttattgcc gcttttgata gcgtatacag gcggaaaaat 431521 gatctacgac caccgcggcg gagttgtcgg agcgacagcg gcaattgggg tgattgtagg 431581 atcggatatt ccaatgtttt taggcgcaat gattatgggt ccgcttggcg gatacctcat 431641 taaacagact gataaattat tcaaggataa agtcaagcaa ggctttgaaa tgctgatcaa 431701 caactttacg gcagggattg tcggcgcggc tttaacgatt ctcgcgtttt acgccatcgg 431761 cccggttgtc ttgacgctaa ataaattgct ggcggctggt gtggaagtca ttgtacacgc 431821 taatttactg ccggtagcca gtgtttttgt agaaccggcg aaagtgttgt tccttaacaa 431881 cgccataaac catggaatct taagcccgat cggaatcgag caagcatctc aaacaggaaa 431941 atcaattctg tttttagtag aagcaaaccc tggaccgggg ctcggcattt tgctggccta 432001 catgttcttt ggcaaaggat cttcaaaatc aacggctccc ggtgcggcga tcatccattt 432061 cttcggaggg attcacgaga tttacttccc gtacattctg atgaaaccgg ccctgattct 432121 cgcagccatt gccggcggag caagcggact cttaacattt acgatcttta atgccggact 432181 tgtcgcggca gcgtcaccgg gaagcattat cgcattgatg gcaatgacgc caagaggagg 432241 ctatttcggc gtattggcgg gtgtattggt cgctgcagct gtatcgttca tcgtttcagc 432301 agtgatcctg aaatcctcta aagctagtga agaagacctg gctgccgcaa cagaaaaaat 432361 gcagtccatg aaggggaaga aaagccaagc agcagctgct ttagaggcgg aacaagccaa 432421 agcagaagaa gcgtctgagc tgtctcctga aagcgtgaac aaaattatct ttgcgtgtga 432481 tgcgggaatg ggatcaagtg ccatgggggc atccatctta agaaacaaag tgaaaaaagc 432541 ggagcttgac atcagtgtga ccaacacggc cattaacaat ctgccaagcg atgcggatat 432601 tgtcatcacc cacaaagatt taacagaccg cgcgaaagca aagctgccga acgcgacgca 432661 catatcagtg gataacttct taaacagccc gaaatacgac gagctgattg aaaagctgaa 432721 aaagtaatct tatagaaaga gagtgattgt catgcaagta ctcgcaaagg aaaacattaa 432781 actcaatcaa acggtatcat caaaagaaga ggctatcaaa ttggcaggcc agacgctgat 432841 tgacaacggc tacgtgacag aggattacat tagcaaaatg tttgaacgtg aagaaacgtc 432901 ttctacgttt atggggaatt tcattgccat tccacacggc acagaagaag cgaaaagcga 432961 ggtgcttcac tcaggaattt caatcataca gattccagag ggcgttgagt acggagaagg 433021 caacacggca aaagtggtat tcggcattgc gggtaaaaat aatgagcatt tagacatttt 433081 gtctaacatc gccattatct gttcagaaga agaaaacatt gaacgcctga tctccgctaa 433141 aagcgaagaa gatttgatcg ccattttcaa cgaggtgaac tgacatgatc gccttacatt 433201 tcggtgcggg aaatatcggg agaggattta tcggcgcgct gcttcaccac tccggctatg 433261 atgtggtgtt tgcggatgtg aacgaaacga tggtcagcct cctcaatgaa aaaaaagaat 433321 acacagtgga actggcggaa gagggacgtt catcggagat cattggcccg gtgagcgcta 433381 ttaacagcgg cagtcagacc gaggagctgt accggctgat gaatgaggcg gcgctcatca 433441 caacagctgt cggcccgaat gtgctgaagc tgattgcccc gtctatcgca gaaggtttaa 433501 gacgaagaaa tactgcaaac acactgaata tcattgcctg cgaaaatatg attggcggaa 433561 gcagcttctt aaagaaagaa atatacagcc atttaacgga agcagagcag aaatccgtca 433621 gtgaaacggt aggttttccg aattctgccg ttgaccggat cgtcccgatt cagcatcatg 433681 aagacccgct gaaagtatcg gttgaaccat ttttcgaatg ggtcattgat gaatcaggct 433741 ttaaagggaa aacaccagtc ataaacggcg cactgtttgt tgatgattta acgccgtaca 433801 tcgaacggaa gctgtttacg gtcaataccg gacacgcggt cacagcgtat gtcggctatc 433861 agcgcggact caaaacggtc aaagaagcaa ttgatcatcc ggaaatccgc cgtgttgttc 433921 attcggcgct gcttgaaact ggtgactatc tcgtcaaatc gtatggcttt aagcaaactg 433981 aacacgaaca atatatcaaa aaaatcatcg gtcgctttga aaatcctttc atttcggacg 434041 atgtgacccg cgtagcgagg tcacctctca gaaaactggg agaaaatgat agacttgtag 434101 gcccggcaaa gaaaataaaa gaaccgaatg cactggctga aggaattgcc gcagcactgc 434161 gcttcgattt caccggtgac cctgaagcgg ttgaactgca agcgctgatc gaagaaaaag 434221 gatacagcgg cgtacttcaa gaggtgtgcg gcattcagtc ccatgaaccg ttgcacgcca 434281 tcattttaaa gaaacttaat caataaccga ccacccgtga cacaatgtca cgggcttttt 434341 ttactatctc gcaatctagt ataatagaaa gcgcttacga taacagggga aggagaatga 434401 cgatgaaaca atttgagatt gcggcaatac cgggagacgg agtaggaaaa gaggttgtag 434461 cggctgctga gaaagtgctt catacagcgg ctgaggtaca cggaggtttg tcattctcat 434521 tcacagcttt tccatggagc tgtgattatt acttggagca cggcaaaatg atgcccgaag 434581 atggaataca tacgcttact caatttgaag cagttttttt gggagctgtc ggaaatccga 434641 agctggttcc cgatcatata tcgttatggg ggctgctgct gaaaatccgg agggagcttg 434701 agctttccat taatatgaga cccgccaaac aaatggcagg cattacgtcg ccgcttctgc 434761 atccaaatga ttttgacttc gtggtgattc gcgagaacag tgaaggtgaa tacagtgaag 434821 ttggcgggcg cattcacaga ggcgatgatg aaatcgccat ccagaatgcc gtgtttacga 434881 gaaaagcgac agaacgtgtc atgcgctttg ccttcgaatt ggcgaaaaaa cggcgcagcc 434941 atgtgacaag cgccacaaag tctaacggca tttatcacgc gatgccgttt tgggatgaag 435001 tctttcagca gacagccgct gattatagcg gaatcgaaac atcatctcag catattgatg 435061 cgctggccgc tttttttgtg acgcgtccgg aaacgtttga tgtcattgtg gcgagcaact 435121 tgttcggtga tattttaacc gacatcagct caagcctgat gggaagcatc ggcattgcgc 435181 cttctgcgaa catcaatcca tccggcaaat atccgtccat gtttgaaccg gttcacggct 435241 cagctcctga cattgccgga cagggccttg ccaatccgat cggccagatt tggacagcga 435301 agctgatgct cgaccacttc ggagaggaag aattgggggc gaaaattctg gatgtaatgg 435361 agcaagtgac tgccgacggc atcaaaacac gcgacattgg gggacaaagc acaacggctg 435421 aggtcactga tgaaatctgt tcgcgcttaa gaaagctctg atgaatcagg ccggtggcag 435481 atggctgccc cggcctgtcc atttccttac gaaaatttcc acgaaagtct aaccaagcag 435541 atccaaatgc tgtataataa tttggaattc ttaggaaagc atcgggtgaa ggaagttgaa 435601 tgcaaaaaca atcacgttaa agaaaaaaag aaaaatcaaa acgatcgttg tactcagtat 435661 cattatgatc gcagctctca tttttacgat cagattggtg ttttacaagc cttttcttat 435721 tgaaggatca tcaatggccc caacgcttaa agactcagaa agaattctgg ttgataaagc 435781 agtcaaatgg actggcgggt ttcacagagg agacatcata gtcattcatg acaaaaagag 435841 cggccgctca tttgtcaaac gtttaatcgg tttgcctggt gacagcatta aaatgaaaaa 435901 tgatcagcta tacataaatg ataaaaaggt ggaagaacca tacttaaagg aatataaaca 435961 ggaggtcaaa gagtcgggtg taaccttaac aggtgacttc gaagttgagg ttccttccgg 436021 taaatatttt gtgatgggag ataaccgtct caattcactg gatagcagaa acggaatggg 436081 catgccttct gaggacgata tcatcggtac tgaatctctc gtcttttatc cattcggtga 436141 gatgagacag gcaaaataaa atgcaatgca aaaagaacat ggaacatgac ggcaccgata 436201 ataaagcgcc gtgcacgttt aaaaaaatga tgatgaaacg gtgcggagcc ggctttccgc 436261 cccgtttttt atgatagaaa gcgttttgaa gaaaagggcc ctgttgaaat aaacagaatc 436321 aggattggcg aagccgtgaa gcgcatcgaa ttggtaaatc tcaagatggg tatgctgttt 436381 ttcccgcagt tttttgataa gaagcgctac gtcaaacgac ggctcataat tagggaaaaa 436441 caataggacc gggcaggctg gcatgtgatg aagagagtcg cgtatccggg aaccgtaata 436501 acaaaccgat ccgctcacct caggcatact gctgcatttc catgcgatag tagcccccac 436561 gctgaatcca atcacaaaga tgtgccgtcc ggcgttttgc ctgatcacat tctggatgat 436621 ggtttctccc gttttcagcc tttcgtgttt tgtaaattgt tcgtatgccg ttttttcttc 436681 tttcagtgtg tagacttcat cctcgccgag caggttgggc gtcaacacat catatccagc 436741 cattttgatc agccggccca tctttttcat atggctgttt acaccatata tttcgtgtgc 436801 gagaatgaca agcggttttg ggaacataac ggcctccttt tgtgtttttt ccattatatc 436861 ctatcgtttc actttaggct gagatataat ggtcaaaaaa aggagatata aaatgaactc 436921 attatctttg cctcaccgct atccattttt gtttattgat ggcgtgacgg atagcgagcc 436981 cggcaaacat gcggcagctt ataagctgat tagtgagaac gactggttta tcactgatac 437041 gcaaacagaa atgccgtttt cacttgtgat tgaagcgctt gcgcaaaccg cggcttttac 437101 aggaattaca gatgagaaca gcttgggatt attgtcttcg gtgaagaaag cggaaaagct 437161 gggagaagct gtgcctggtg accggcttga tcttacgttt gaagtcacgc gcaatcggcg 437221 cgggtttgtg ttcggacatg ccaaggcatc agttggagag cagcctgttg ctgaagctga 437281 aatcggcatc tatattgaaa aatgaaaaaa acccttcaca acattttgtg aggggttcta 437341 ttttgtgtcg taatcccgtt cgctttgaga gttatctctt tgctggcgtt tgtgtttttc 437401 atcattcata ttttccttca gctcttcatt aggaatcgga tcggttaagt cgttgtgctc 437461 ggggttttca tttggtttgt tttgctgttt tttttctgtc atgtttgatc acctcaccgt 437521 ttgttttcct cttattcatt ctcctcaaac ataggaaatc gcttttttgt cccgctgggt 437581 ataatgtatt agaatagaga gaagcacaac aaaaagataa agagaggtac atatatgtct 437641 gttcaaagag aagatgtaga tatcaagctg atcgcaattg atatggatgg tacactgctg 437701 aacgacgagc agctgatctc ggatgaaaac cgcaaagcca ttcgtgaagc ggaggataaa 437761 ggtgtgtatg tggtgatcag cacgggccgg acgctgatga cgtgcaggga gctggcggaa 437821 tcgctaaagc tgtcatcctt tctaatcacg gcaaacggca gtgaaatttg ggattcgaat 437881 tttaatttgg tggaacggaa gctgcttcat acggaccata ttcaaatgat gtgggatttg 437941 cggaataagc acaacactaa tttctgggct tctacggtga ataaagtatg gagaggcgag 438001 tttccggaaa acattacgga tcatgaatgg ctcaaattcg gctttgacat cgaggatgac 438061 gatatccgaa acgaagtgct tgaggagctg agaaaaaaca aagagctcga aatcacaaat 438121 tcaagtccga caaacattga agtcaacgcg cttggcatca acaaagctgc agcccttgcc 438181 aaggttacgg aaaaactcgg ctttacaatg gagaatgtga tggcgatggg cgacagcctt 438241 aatgacattg cgatgatcaa agaagcgggt cttggcgtcg caatgggcaa tgcgcaagac 438301 atcgtaaaag aaacggctga ttatatcacg gatacaaata ttgaggatgg tgtcgctaaa 438361 gcgattcgcc attgggtact ataaaaaaag agagtcctaa gatggactct cttttttagt 438421 ttggcaggtt ttattctggg accatggtag gttttctgac aaaagtattt cacaaactga 438481 tatgattcac ttataatgaa ataaagttca aaaattcgga atagtcgttc cgaatttcgg 438541 gacaataaat gacataaagc atatcgtttg ctttggcagg agggattctg tgtttcagat 438601 tgatttaaac tgtgatttag gagaaagctt cggagcctac aagataggcc ttgaccaaga 438661 tattttagag tatgtgacat cagcgaatat cgcatgcgga tttcatgcag gagatcctag 438721 tgttatgcga aaaaccgtcg cgcttgcagc agaaagaggc gtgaaaatgg gtgcgcatcc 438781 gggcttgccg gatttactcg gttttgggcg ccgcaatatg gcgatttctc ctgaggaagc 438841 gtatgatctt gtcgtttatc aaattggcgc gctctctggc tttctaaaag cagagggact 438901 tcacatgcag cacgtcaagc cgcatggcgc tttatacaat atggcggcag tcgatcaaaa 438961 actgtcggat gctatcgcga aagctgtcta taaggttgat cccggcctga ttcttttcgg 439021 tcttgctgag agcgagcttg taaaagcggg agaacggatc ggacttcaga ccgcaaatga 439081 agtgttcgcc gacagaacat accaatcgga cggcacgctg acaccgcgct cccagccgga 439141 cgcactcatt gaaagtgatg atgccgccgt cacccaggtc atcaaaatgg tgaaagaagg 439201 ggcggtcaaa tctcagcaag gacatgatgt gtcattaaaa gcagatacag tctgcattca 439261 tggagatgga gcccatgcgc tgacatttgc gcaaaaaatc agaaaacagc tcaaagcggc 439321 tggaattgaa gtgacagcta tttcagaaca gaggtcaaca taaaggagga acaatagatg 439381 gagcagcaga aaaagacagc aggaaaaaaa gcgggcagct ggtcattgct gatgggcgcc 439441 gcctttttaa tggcgacatc agcaatcgga ccgggtttcc tcacccaaac cgcaacattc 439501 acaaacacac tcgcagcaag cttcggtttt gtcatcttaa tctctattat tttagatatt 439561 ttcgcccaaa ccaatgtgtg gcgcatcatc gcagtttctg gaaaacgagg tcaggaaatt 439621 gcgaatatgg tgcttcccgg actggggtat ttcatcgcca ttctcgtcgt gcttggcgga 439681 ctagctttta atattgggaa tatcggaggg gccgggctgg gacttcaggt gctgttcggc 439741 attacacctg aaacaggcgc tttaatcagt gccgttatcg ccattttgat ttttgtcatc 439801 aaggaagcag gaaaagcgat ggaccgtttt acgcaaatcg cggggttcgt gatgattatt 439861 ttaacggtct acgttgcggc gacgacagct cctccggtcg gacaggcagt cgcaaataca 439921 ttcgtcccgg aacacatcag catatttgcc attgtcaccc tagtgggcgg aaccgtcggc 439981 ggttatatca catttgccgg aggacaccgt ttgcttgatg ccggaattaa aggaaaggaa 440041 tccattccgc aggtgacaaa gagctcggtt gtcggcattt taattacatc tgtcatgcgt 440101 atcgctcttt ttcttgcggt tctaggcgtt gtatcgaaag gcctgcacat cgatgaaagc 440161 aacccggcgg cttctgtctt caagctggct gctggaaatg tcggttataa aattttcgga 440221 ttgatcatgt ggtctgcggc gattacgtct gttattggag cagcctatac atctgtttca 440281 ttttttaaaa ccttttctcc aaaaattgaa aagaattcac gcggtattat tatcggattt 440341 attgtggttt ctacgttagc ttttgtcaca atcggccagc ctgcgaagat cctcgtcctt 440401 gtcggttcac tgaacggctt aattctgccg attgcgctcg gaacgctgct tgttgccgcc 440461 tacaagaaaa acattgtcgg tgattataag catccgcttt ggctgacaag cacaggcgcg 440521 cttgtagtga ttgtaatggc agttatggga atctacacgt tatgtacaca acttcctcaa 440581 ttgtggagct gatataagtg gagcaattaa acaaaatggc gccaaaggat gtacgcgccc 440641 tgatacgaga ggggaaaata aacgggccga ccgcaggcat gtccggcggc tacgcccaag 440701 cgaatcttgt ggttttgaaa aaggaccttg cgtttgattt tctgctgttt tgccagcgaa 440761 atcaaaagcc ctgccccgtg ctggatgtga ctgaagcagg ttcgcctgtg ccgtctctgg 440821 ctgcgccgga tgctgatatc agaacggact ttccgaaata ccgtatttac aggcacggta 440881 tcctaacgga agaagtatct gatattacgc catactggga ggacgatttt gtcggctttc 440941 tgatcggatg cagtttctcc tttgaacagg cactgatcaa taatgggata gctgtccggc 441001 atattgatga ggggacaaac gtctcaatgt ataaaacgaa tatcgattgt gttccggcgg 441061 gggcgtttca cggacagatg gttgtcagca tgaggccggt tcctgaacgg ctggctgtac 441121 gtgctgcaca agtgacctcg cgttttccgg ctgtgcacgg agggccgatc catattggca 441181 atccgggagc aatcgggatt cgcgatctcg ggaaaccgga tttcggagat gccgtttcca 441241 ttcgtgacgg cgaggttcct gttttttggg catgcggagt gaccccgcaa gccgtggcta 441301 tgaatgtaaa gcctgaaatg gtcatcacac atgcgccggg gcatatgctc atcacagata 441361 ttcgagacga gtcgcttgcg gtgctgtagc ctctcgtcat cctgatgaac gagaattaaa 441421 agaggtgaga aagatgactg tacgatatca aatcgaacag ctcggtgatt ctgcaatgat 441481 gatccgattc ggagaagaaa tcaatgaaca ggtcaacggc attgtccatg cagcggccgc 441541 ttatatagaa gaacagccat ttccgggatt cattgaatgt atcccggctt ttacaagtct 441601 aaccgtattt tatgatatgt atgaagtgta caagcatttg cctcaaggca taagctcacc 441661 ttttgagagt gtcaagcgcg atgtcgaaga gcggctggca gaaatagccg aagactatga 441721 ggtcaaccgc cgtattgtag aaattcccgt ttgctatggc ggtgaattcg gtccggattt 441781 agaagaggtg gcgaagatca atcaactgtc accggaggaa gtaatcgaca ttcatacaaa 441841 cggtgaatat gtggtgtata tgcttggctt cgcgcccggt tttccttttc taggcgggat 441901 gtcaaaacgc attgcagctc cgagaaaatc atcgccaaga ccgtcgattc ccgcaggttc 441961 ggtcggtatt gcgggattgc agacaggcgt ttatccgatt tcaacgccgg gcggctggca 442021 gctgatcggc aaaacgccgc tggctctttt ccggccgcag gaaaacccgc cgacattgct 442081 gcgggcggga gatattgtga aattcgttcg catctcagaa aaagactatc acgcctataa 442141 ggaggagtcc aattgagcat gaaagtatta aagcccggac tgctcacaac ggttcaggat 442201 ataggcagaa cgggttacca aaaatacggc gttctggcca gcggcgctat ggacacggtt 442261 tcactgcgca ttgccaatct gttgatagga aacggcgaaa atgaagcagg tctcgaaata 442321 acgatgatgg ggcccggtcc gtcgtttcat ttttcaaaac agacactgat tgctgtgaca 442381 ggggcggact tcacgctgcg tattaatgac gaggaagcgc ctttatggaa gcctgtgctc 442441 atcaaggaaa acagcacggt cagctttggc ccctgcaaac tcggcagccg tgcttatttg 442501 gcggcagctg gcggcattga ggtgcctgcc gtcatggaaa gtaaaagcac atacgtcaga 442561 ggaagcattg gcggacttca tggcagagcg cttcaaaaag aagatgaact gaacattgga 442621 gagatgtcag ctctttcgca aaccatcctt tctcgcttaa gttcgcagct tggaaaacag 442681 ggatttgcag caccgaagtg gtcagtcagc cgcggcagat ttctgccatt gaagaagaat 442741 cccgtcattc gggtgctgga aggaaagcaa tttgcctttt tcacagaaga atcaaaaacg 442801 cgtttttatg aagaagcatt tcgtgtcacg ccgcagtccg accgtatggg ctacaggctc 442861 aaaggagaac cgctcgaact gaaggccccg cttgagatgg tgtcggaagc ggtttcattc 442921 ggaacagttc aggtgccgcc tgacggcaac ccgattatcc tgcttgcaga ccggcagacg 442981 actggcggct atccgaggat cgcgcacatc atatccgctg atcttccgat tgtttcccaa 443041 atcatgccgg gcgagcacgt tcagtttgag cctgtgtccc tccaggaggc agaagcgctt 443101 gcggtagaac gggaacagca tataaaagaa ctgaaaacga gaatgaagat ggaatggctg 443161 acatagcaaa ggggatgaat gatgcagaat aaaaataaaa ccgtagtcaa atctatggcg 443221 ctgcttaatt tgtttttgca taaaccaagc ctaaccttaa gtgaactggt gtcgctgacg 443281 ggaatgccga agacctctgt tcaccggatg gtcagctcct tggaggaaat ggggttcctc 443341 agtcgggatg cgtccggcgc ttattcgctg ggattggtgt ttttggaatt cggacagctt 443401 gtcgctgaca ggctggatat cagaaaaata gcgaaaccgg tgatggaaga gctgtgccgg 443461 gaagtggatg aggccgtgca gttgatcatg agggacggca atgaagcgat atacgttgag 443521 aaaatagaag ggacacagac tgtgcggctg tatacggcga tcggcaggcg ttccccccta 443581 tacgcgggag cgtgcgccag aagcattctg tcctttcttc cccgtgaaga aatcgaagca 443641 tacatcaaac aaaccgagct catttcgatt ggctccggaa cgattaccga tcccgaaaaa 443701 ctgcttcagg agattgatgc ctctgtgcaa aatggctata ctgtcagcta ttcagagctc 443761 gaaaactata cggcggcgat cggcgccccg atctttaacc atgagcgcca ggtggcagcc 443821 ggcattagca ttgcaggctt tgaagcgaga tttacagaag acaggctgcc ctatttaaca 443881 gaaaaggtga aggacgccgc tttacagatt tcaagaaaaa taggatatac ataagtagcc 443941 aatcttttct ctgctgcgta cattaacgta tcgacgttca agagtggagg aaagaacatg 444001 gtgcttcgat atacagctct gggcgattcc ttgacgacag ggagaggctc cgggctgttt 444061 tcacccggct tcgtccagcg ttttggggac atgatggaag ctgacttgaa aacaagaacg 444121 gcaataaaca tatttgccag atcaggtctg aatacagaag agattttggg actcctgtca 444181 tatccctatg tgcaaaaatg tattcgagat gctgatatga taacgatcac agggtgcgga 444241 aacgatctca tcgattcggt cttagcctac caaacctcta aggatgaaac gattttcagc 444301 cgtgtatccg cccattgcca tgagaatttt gaaaagatga ttgccaaagt cgccgagatt 444361 aaaggagaaa atccttcccc gtacgccatt cgtgtgttca acttatacaa tccgtttccc 444421 gaaattgata tcgccggcaa atggatcact tcgtttaatt cacatttaga aacacttgca 444481 tcagcacccc atgtcaaaat cgcggatgcc tatagcatct tcaaaggcaa agaacaggaa 444541 tatctgtcct ttgacggtgt ccatccgaac agcaaaggct atcaagcgat ggctgaagcc 444601 gttcacaagc taggctataa agaattatca gtttcataga aaacgcgcct catgacaggc 444661 gcgtttttta tgtgtgatcg aaatattaaa agaaacttaa aattctctgt cttctgttct 444721 acagacaaac aaagtgcgct agaataatgg agggcgtagg caaatatagc cataacgttc 444781 aatatttcgt atataaggaa ggatggtcct tttgtttcgg atttttaaaa tgtcttttgc 444841 ggttatcatt attatactgg cgcttattgc ttttaactat acggaacaca cctctgtaat 444901 ccaatcggtc atgctcgtct ttcttggtgc ggtcatgttt atgcaggggc ttgaagagcg 444961 caaaaaagaa aatgacggct caggcgcttt taatatttat accgccgttt ttgtatggtc 445021 tgtctccctt atcggtttta cacttcatat tatataaatc tattacacat cctgaaaatg 445081 ctcgaccgtc gggaacgggg tatagaaccg atgaagcaag gctttccact cttgatactc 445141 tgaagaaccg cgaaagcctt ccgtatggtc ctcaagtgtt tcccactcca caagaagcag 445201 atatttatgc gtttcctcca tgcattttga taacgagtga gtgatatagc ccttcatgcc 445261 ggaaataatc ggcgcagctt gccggaatgc atcctcaaac tcttgttcaa ggccttcttt 445321 aatgtgaagc attgctgcct ctctgaccat gctatccctt ctttctgtct tttcaaatag 445381 tctacagcaa acgataggag atttctgcaa aatcggtgaa cttttccttc attttcaaaa 445441 aaatcttgca cgcaccaatt caattaagag aaaataacaa gtggaaggca ggggaaagtc 445501 atgttaaaaa agtgtattct actagtattt ctatgcgtcg gattgattgg gttaatcgga 445561 tgctccaaaa cagattcacc agaggatcgc atggaagcat tcgtgaaaca gtggaacgat 445621 cagcaattcg atgacatgta tcaaagcctg actaaagatg tcaaaaaaga aatctccaaa 445681 aaagatttcg tcaacaggta taaagccatc tatgagcagg ccggcgtaaa aaatttgaaa 445741 gtcactgcgg gagaagtaga taaggacgat caagacaaca agacgatgaa acatatcccg 445801 tataaagtca gcatgaacac aaatgccggc aaagtcagct tcaagaatac tgctgtgctg 445861 aaattagaaa aaacagatga cgaggagtca tggaatatag attgggaccc atcgtttatt 445921 ttcaagcagc tggctgacga caaaaccgtg caaattatga gcattgaacc gaaacgaggc 445981 caaatttacg ataaaaatgg aaaaggctta gccgtcaata cagatgttcc ggaaattgga 446041 attgttcccg gagagcttgg cgataaaaaa gagaaagtca taaaagaact cgccaaaaaa 446101 cttgatttga ctgaagacga catcaagaaa aagctggatc aaggctgggt aaaagacgat 446161 tcgtttgtgc cgctcaaaaa ggtcaagcct gaccaggaga aattagtttc tgaagcgacg 446221 tcattacaag gcgtaacaag aacgaatgtc agctcccgct actatccgta tggcgaaaag 446281 acagcccatt tgacaggcta tgtccgcgcc attacagcgg aagaactgaa gaaaaagaaa 446341 gaaggaacgt acagcgatac gtctaacatc ggtatcgccg gacttgaaaa tgtgtatgaa 446401 gacaagctaa gaggcacaac tggctggaaa atctacgtgc cgcaaaccgg ggaagtcatc 446461 gctgaaaaga aagcaaagga cggcgaggat cttcacctca caattgatat caaaacgcaa 446521 atgaagctgt atgatgaact gaaggatgac agcggggcgg cagtcgcgct gcagccgaag 446581 acaggcgaaa cactcgccct tgtcagcgcg ccttcctacg atccaaacgg atttattttc 446641 ggctggagcg ataaggaatg gaaaaagcta aacaaagata aaaacaatcc gttttcagcg 446701 aaattcaata agacatacgc gccaggttct accattaaac cgattgcggc tgctattgga 446761 atcaaaaacg gcacccttaa agccgatgag aagaaaacaa tcaaaggcaa ggagtggcaa 446821 aaagattcaa gctggggcgg ctattcagtg acacgtgtgt ctgagagact tcaacaagtc 446881 gatttggaaa acgcccttat tacgtcagac aatatttatt ttgcccagaa tgcgcttgat 446941 atgggagcgg acacctttac aaaaggcttg aagacattcg gtttttcaga ggacgttccg 447001 tacgaattcc cgatccagaa atcgtctatt gcaaatgaca agcttgattc agacattttg 447061 cttgcggata caggctacgg acaagggcaa atgcaaatgt ctccgcttca cttggcaact 447121 gcttacacgc catttgttga caatggagac cttgtcaaac cgacgctgat caaaaaagat 447181 tcacaaacag ctgatgtttg gcacaagcaa gtggtcacga aggaaggagc ggcagacatt 447241 acaaaaggtc tgaaaggcgt tgtggaagat gagcgcggat cagcgtatca gcctgtcgtg 447301 aaaggaatca cagtggctgg aaaaacagga acagccgagc tgaaaacatc aaaagatgat 447361 aaagacggca cggaaaatgg ctggtttgtc ggctacgatt acgaaaacaa agacctgctt 447421 gtcgccatga tgatccaaaa tgtgcaggac cgcggcggca gccactatgt cgttgagaaa 447481 gcgaaaaagc aatttcaatc gaattaaaat gtctttttaa aaggagcgaa aggaaaaagg 447541 ggatctgagg ccgaatgaac tagtaagggg gcaaaacccg gtttatacaa agaaaagagg 447601 gattttgcat gcagcgtatt caattggcgg aggatcttca attttcaaga gtcatacacg 447661 ggctttggcg gctgaatgaa tggaactatt cagatgctga acttctaagc ctcattgaat 447721 ggtgtatcga tcacggcatc acgacctttg atcatgcgga tatttatgga ggctatacgt 447781 gcgaaaagct gtttggaaac gcccttgccc tttcgcctgg attaagagaa aacatagagt 447841 tggtcacaaa atgcggtatc gttcttgaat cgcctgaacg gcccgctcac agatcgcatc 447901 attataacac aagcaaatcg catattttgg catccgttga gcaatcgctt atgaacctta 447961 ggacggatta tatcgatatg cttttgattc acagaccgga cccgctcatg gatccggagg 448021 gggtagcaga ggcgtttcag gccttgaaat gctctggcaa ggtcaggtac tttggcgttt 448081 caaattttaa agatcaccag tatcggatgc tggaatcata tttgcctgag aagctcgtaa 448141 ccaaccagat tgagctttcc gcatacgaat tagaaaatat gctcgacggc actttgaacc 448201 tgtgccagga aaaacggatt ccgccgatgg cttggtcgcc tctggcaggc ggcaaagtat 448261 tcactgaaaa cacggataaa gaccgacgtg tccgtacggc gcttgaatcc gtccaagggg 448321 aaatcggcgc cgcttcattg gacgaggtga tgtacgcatg gctgtatacg catccggccg 448381 gcatcatgcc gattgtcgga agcggaaagc gcgagcggat ttccgccgcg ataaatgcgt 448441 tgtcatacaa gcttgaccag gatcaatggt tccgcatttt tacagccgta cagggttacg 448501 atattccata aaaagcatca gtttaccagc tgatgctttt tcaatattgt cacaccgctt 448561 agtgccaaat taccatttat aagtgattga ttctttcttg aaagcgtttt atattaaaag 448621 gaaacctctc tatatcctct actgcatctc cttgcgactt catccgcaca tcaagattgg 448681 ctaggaggtc ttttttatgt atatgactgc cagagaacaa aagctgttaa agcacttatt 448741 attacaaaac agatatataa ccgtaactga gcttgctgag ctgatgcaag tcagcacgag 448801 aaccattcac agggaactca aatcaattaa accgctgatg gaaaccgtgg ggcttacgtt 448861 agataaacag cccggtaaag ggttgaaagc agtgggaagt cccgagggta aacaaaagct 448921 gcttactgat ttatcatatg aacagcatga atacagcgcc gacgaacgga aactgctcat 448981 tctttgttcg ttattagagt ctcaggagcc cgtcaaactg tacacgcttg ctcatgatct 449041 ccaggtgacg aatgccacgg tcagctatga cttagatgag ctcgagaagt ggatttctcc 449101 ctttggactg acactgatcc gcaaaagagg ttttggcatc cagctcatag ggccggagaa 449161 tgcgaaacgg aaaattgtcg gcaacttgat tgtgaaccgt ctcgacatcc aaatgttttt 449221 ggaagcggtt gaattaaaca tcaaaggaaa aaccgattct tcagagaaaa tgttcggggt 449281 tgtcagcaaa ggtgagctgt taaaaatgga gcgcatctta tttcagctca aagaaaaaat 449341 cgctttttca ttgtccgaca gctcctatat agcgctcgtc gtccatctga cgtatgcgat 449401 cgaacgaatt aagcttgggg aaactatcac catggagcaa aatgagcttg aggaactgat 449461 gaatgcgaag gaatacagct ccgctcttga aatcgcgggc gagcttgaac gtgccttcgg 449521 cgtgacgatt ccagaggcgg aggtcggcta tattacaatc catcttcgaa gcgccaatcg 449581 aaaatacaaa acagaataca aagcgcagga aattgagctg gaaacagccc tgcaaacaaa 449641 gcggctcatt gcttttattt cagacaaaat cagaatggat ctgacgaaaa actactcttt 449701 atatgaaggc ttgattgccc atttggagcc ggccgtcagc cgcataaaag aaaatattga 449761 gatatacaat ccgatgaagg aacagatcaa gcgcgattat tttctgcttt atatggcgat 449821 cgaagaaggt gtcgaaaagt attttccggg catgtccttt tctgatgatg aaatcgcttt 449881 tatcgttctt cactttggct cggctcttga aatcaaaaaa gaagaagcaa aagtgaaagc 449941 gcttgtcgtc tgctcaagcg ggatcggctc ctcgaaaatg cttgcctcca gactgaaaaa 450001 agagctgccg gaaattgaat cgtttgatat gtcatctctg atcgagctaa aggggaagga 450061 tgttcaagcc tatgatatga ttgtgtccac tgtaccgatt ccttatgaaa acattgatta 450121 catcatggtc agcccactat taaatgagga agacgcaaac caggtcaagc agtatatcaa 450181 gcggaagatt ccccttattc ttaacaaaaa aagaagctcg aaggaagagg cgcagcaagc 450241 tgatgtacct gacatgctgg aggcggcgga aagcataggg cggtatatgg aagttatcca 450301 agatgttctg cgccatttta cgctagctca actcaaaaca aacccggacc atagcatgct 450361 tctgctagag ctttttcaac agctgaagaa ggatggcctg atccgtgatc cggaaaaagc 450421 cgcggtttgc ctggctgagc gggagaaaca agggggattg ggaatccccg gaacaaacat 450481 ggcgctttat catctcaaaa atgatgaaat cgtcctgcct tttttcaaaa tgtttgatct 450541 cagcaccccc tatgaagtgg atggcatgga cggaaatacc ctcaggatga cacgcattct 450601 cgtcatgatg gcgcctggct cattatctgc tgaaggctcg gagattttaa gcgcgatcag 450661 ctcggcaatt atcgagagcg gagaaagcat ggcggggttt caggaagaag gaggacaaga 450721 attgtatcag cggttaaacc gcatattttt cacatggatg aaagaaaaaa acatactgta 450781 aacctgcatg gcacacgtca aaaatttggc gtgtgttttt ctgtggatgg ggaacaaaat 450841 aagaaaatgt gggactattt tatcattcag tattggaata attccaaaat gaaatagttt 450901 tacaagttat cttttttggg ttaaaatggg tgaggtaagg aagaaaatct aacaaattat 450961 tgaagattca agagaatata ggagatgacg atatggaaac attacagcat ctgattctgc 451021 atgacatgcc gaatagcgaa gaaatagagg ctgtaaaaag cggagaccat acactgacat 451081 ataaaggtta ccgtaaacgg attaatcagc tggcgaatgc catgcttcaa aaaggaattc 451141 aaaagggcga ccgtgttgca ttgctttgca aaaacggcca tcccgcctca actgttatgt 451201 tcgccgcact tgaaataggt gctgttgtcg tacctgtcag ctggcagctg aaaccatatg 451261 aaatgacagg cattttaaaa gcaagtgaac caaaagcgat gttttacgga gcggagttta 451321 aagagatact ggatgaagtt cttcctgaat tgtcctcact gtgtgtaaca atggaaacag 451381 gaacagctta cgaaacatct gctgaatttg aagcgctgtt tgcaggtcct gatcatttgc 451441 cagagacgga aatggtttca cctgatgata cagcacttct gatgtttaca tctggaacaa 451501 cgggaaaccc gaaaagatgc atgattacac atggcggcat atacagatac gttaaaaaat 451561 ccaacagctc aatagcacgt atgaagggcc ttcgttttct cgcgtgccat ccgatttatc 451621 atacgagtgc gctcatttgc atcatgcttg gaacgtttgc agaaacaaca tttgtgttta 451681 caaaggatca agatcctgtt cacatgctga aggtcattga agaagagaag attcagaccg 451741 tgatggctct tcctgtgttc tacacgtatt tgcttgaggc gtgggaaaag caccaaactg 451801 acttatcttc gcttgttatt ttaatgacag gcggaacaaa agtgccgagc agcctaataa 451861 gccgctatct tgatattggc attccgcttg cgcatggcta tggaagtact gaggcttggg 451921 gcatcagcac atggacgcct gatatgggaa tggataaagc ggcatctgca ggaaaacctg 451981 tggcaggtgt taaagtcaaa gtggaagatc ctctgaccgg agaagaactt cctcaaggag 452041 aaatcggcga aatcgttgtt catactccat tcttatttaa aggctatgaa gacaatcctg 452101 aagcaacagc gaaagtgctg caaaatggat ggtttagaac cggagattca ggatatgtag 452161 atgaagatgg ctttattttc atcacgggac gctacaagga tgtcattatt tacggaggcg 452221 ataacgtcta tcctgatcag gttgaagaag ttatccagca gatcccggga atccttgaaa 452281 cggctgtggt cggtattcct gacccgcttt acggtgaaaa accgaaagct tttatcgtga 452341 aaaatggcgg ccagcgcatc acggaagagg atgtcatcgc attttgtaaa gaacgcctgt 452401 ccgcttacaa aatacctgaa gttgaatttg ttaacgaact gccgaaaaac aaccttggca 452461 aggtgaaaaa agacgtcctg cgcaatcagg ctgtacattc ataaaagaag aagcccgtcc 452521 actttatgtg gcgggcttct ttgcagttgc acagacggaa agctcaggct taatgttctt 452581 aaattgtata tcaatgtctt cgaagccggc tgctttaaag tcagcaatca tctgtcttcc 452641 aaatgatttg gttttctcag gactggcatc cgcttcccgc ggctgcatcg taatggctgc 452701 tttgccgcct ggctttaatg cccgataaat ctgttttatg ccttttgttt ggtcattcca 452761 aatggtgtag ttgttaacgg aaatcacttt atcataaaac gaggcgggga gaggaaatgt 452821 ctcgatgctt ccttgtatca ggcgtacgcc ctttggtttc actctgcggg cggccagctt 452881 cagcatggcc tctgatacat caatcccatg aagatgaaca tccttctcgc gtttcagcat 452941 ctgctgcatg cagtatcccg ggccaaaccc gacttctaaa atgctgtccc cgcgcgtgat 453001 acccagctga ttgattgtcc actgattcag tgtttgattt tcagcagcca tgatgtaccc 453061 ggcaatcatg ccgatgacgc cctttggcct gctgaatctt ctagaaagca tgttaatcat 453121 tcagcaacca accccctttt tgagttaatt tcctctcagc gttccatgtg aaacattttt 453181 ctgataaagc aatgcgaagg tgccaagcca tgtttatcca aagagtgtgt gaggtacaca 453241 acaaatagac atgaaaacaa aggaggagaa tcatcatggc aaattatcca aaagaactgc 453301 cggcacaaac tcaaagtcgc cagccgggaa ttgaaagcga aatgaatcca agtccggtgt 453361 atgagtacga ggattataaa ggagcagaca aattaaaagg aaaagtagct cttattacag 453421 gcggcgacag cgggatcgga cgcgcggttt ccgtcgctta cgcaaaggaa ggcgcagaca 453481 tcgccattgt gtataaggat gagcatgaag acgctgagga gacgaagaaa cgtgttgaac 453541 aagaaggcgt aaaatgcctg ctgattgctg gtgacgtagg tgaagaggaa ttctgcaatg 453601 aagcggttga aaaaacggtc aaggaactag gcggccttga catccttgtc aacaatgcag 453661 gtgaacagca cccgaaggaa agcatcaaag atattacgag cgaacagctt caccgcacat 453721 tcaaaacaaa tttttattct caattttatt tgactaaaaa agcaattgat tacctgaaac 453781 cgggcagcgc catcatcaat acgacatcca tcaacccgta cgtagggaac ccgacactga 453841 ttgattatac agcgacaaaa ggggcgatca atgcctttac aagaacaatg gcgcaggcgc 453901 ttgtcaaaga cggcatccgt gtaaatgcag tcgcgccggg tccaatttgg acgccactaa 453961 tcccagctac gttccctgaa gaaacagttg ctcaatttgg gcaagatacg ccgatgggcc 454021 gtcctggaca gcctgttgag cacgtcggct gttatgtgct tctggcatca gatgagtcct 454081 cttacatgac aggtcagacc ctgcatgtca acggcggaaa ctttgtgacg acataagagg 454141 gagtgagaca tatgggcatc acgaaagaag aagtgaacag ctactatcaa aaagcaggga 454201 ttgtattaac ggacgaggaa gtagaccaaa tccagctgat ggattacggc ttaggaaaag 454261 aaagaaaagt cgggctccag ctcttcgtct acgtcaatac agaccgttat tgttcaaagg 454321 aattggtgct gtttccggga cagacttgcc cggaacaccg ccatccaccg gtcgacggcc 454381 aggaaggcaa gcaggagacc ttccgctgcc gctacggaaa agtgtatctt tacgtagaag 454441 gagaaaaaac gccgcttcca aaagttctcc ctcctcagga agacagagaa cactatacgg 454501 tctggcacga aattgagcta gaaccgggcg ggcaatacac gattccacca aacacaaagc 454561 attggttcca ggccggggaa gaaggtgccg tcgtgacgga aatgtcatcg acgagcacgg 454621 ataaacatga tatctttacc gatccaagaa tataaggatg ggcttaacag cccatccttt 454681 ttgtattgaa aaaaacagaa tcatcgctat aatgggtaaa aaaggaaaga gggcgaggca 454741 atgttcactt gcaaggtaaa tgagcacatc accatccgat tattggagcc gaaggatgcg 454801 gagcggctgg ccgaactcat tatccaaaat cagcagcggc ttggcaagtg gctgtttttt 454861 gcggaaaatc caagcagcgc tgacacgtac cgagaaacaa tcattccaga ttggcggcgc 454921 cagtatgccg acctgaacgg cattgaggcg ggtctccttt atgacggcag cctatgcggc 454981 atgatcagcc tgcataacct tgatcaagtg aatcgtaagg cggaaatcgg atattggatt 455041 gccaaagaat ttgaagggaa aggcattatt acagctgcct gccgaaaact cattacgtat 455101 gcttttgaag agcttgagct gaatcgtgtg gcgatctgtg cggctgtcgg aaacgaaaaa 455161 agcagagcgg ttccggagcg gatcgggttt ctagaggaag gaaaggcacg ggatggctta 455221 tacgtaaacg gcatgcatca cgacctcgtc tactacagtc tgttaaagcg tgaatgggaa 455281 ggcgaaaaat aaagagcaca ctttcttgtt taaatcttcc ccggatgtgg aaaagtaaca 455341 gcggagacgt taaaaaggag tgattcgaga tgaatcagca agacattaaa caaaaagtgc 455401 ttgatgttct agatcaccat aaagtaggtt cgctcgcaac agttcaaaag ggcaaaccgc 455461 attcccgcta catgactttt ttccatgacg ggctgacgat ttacacaccg acaagcaagg 455521 aaactcataa agcggaagaa attgagaaca accccaatgt ccacatttta ttaggctatg 455581 attgtgaagg ttttggcgac gcatatgtcg aagttgccgg aaaagcaaag atcaacaatt 455641 cggcagaact caaggacaaa atatggagtt ccaaattaga gcgctggttt gacggcaagg 455701 atgatccgaa tctggtgatt cttgaaattg aaccggagga tatcagatta atgaatgccg 455761 gggagaaaac accggtctca ctcgaactat aaaaaatttg tgttttcagg ggcgatatgt 455821 tattatgaat agctagtaag aaaaataagc aaataaaaaa gaaagtaaac ttcttttttc 455881 tgttttgaga gagaagctta ccgcttccca agcagcataa ccagctgccc ttattctttt 455941 ccttcataac aaatcgcccc taacgatgag atggaaaaaa gacttttttg ttttacaatt 456001 cacaccggcg cggcttcgga gccgcagtga cgattgagag gtagggcttt cgttgtcttg 456061 tgttcaagaa atttccatgg tgtttacttt ccagaatgat tcttcggaac aatgctttat 456121 gaatctaacc cgcctgactt ggcggatgat ataatcttta tttgcgtata gaaaagaata 456181 agacaaaccg cccggcgtac gccggacggt ttttttattg caaaaaacac atcgtactga 456241 aacctccttg tcttctttcc agtcttatct ctaggatgaa attggaggaa gaataacgtg 456301 catgtcatta caacacaagt actttttatt ttttgttttt tattgctgat tcactcgata 456361 gaaaccttag cctatgcgac aaggctttcc ggagctcgcg ttggatttat tgcgtccgcg 456421 ctttctctgt ttaatgtcat ggtcatcgta tccagaatgt cgaatatggt gcagcagccc 456481 tttactgggc atttaattga tgatgctgga aaaaacgcac tggcgattgt aggggagcag 456541 ttccgctttt taattttcgg atcgacagtc ggcaccattt tgggcattat cctgctcccg 456601 tcttttgtcg ctcttttttc acgggcgatt attcacttgg cgggcggcgg cggctccgtt 456661 tttcaagtat tccgaaaggg attctcgaaa caaggattca aaaatgccct ttcctatttg 456721 cgtctgccgt ccatttcata tgtaaaagga tttcatatgc gcttgattcc gaagcgtttg 456781 tttgtcatca acatgctgat cacatcgatt tatacgattg gtgtgctttc ggctttatac 456841 gcaggccttt tggcgccgga gcgcagcacg acagccgtca tggcttcggg tttgatcaac 456901 ggaattgcaa cgatgctgct ggctattttt gttgatccta aggtatccgt tcttgctgat 456961 gatgtggcaa aaggaaaacg aagctatatc tatttaaaat ggacctctgt cacaatggtc 457021 acatcaaggg tggcgggcac actcctcgcc cagctcatgt ttattcccgg ggcctactat 457081 atcgcgtggc tgacaaagtg gttttaataa gaaaggctgg atcataaaga tccagccttt 457141 ttgcgcttcc ttatttatag ttccttaatc cgcggtcgta caaaaaattt ccgaatggga 457201 cgaaagcggc gatgaagccg gcagctgacc atttcagcgg ccatttgaca gagaaggttg 457261 cataagccaa gacaagcaaa tacaaaatga acaacccgcc gtgaaccgaa ccgacaattg 457321 tcaccgcaag cggaaggcct gcccaatatt taagcggcat agcgatgaac aacaggatta 457381 agagtgacat tccttcaata aaacccatcg tgcgaagtct tccgatcggc gtgtgcagca 457441 taaatcgccc tccttgtgga cacgttttca ttttatacta taaacaatcc gggggggcat 457501 atgacagctt tcaaaaaatg ttcggaaaac attcattttt acatgccttt tctagggaac 457561 tgtacttgtc atttacaaaa atacccgaga taatgtgtac aaaatcaaaa aagaaggatg 457621 ttgaaatgaa acttgaccag attgatctga atatcattga ggagctgaag aaggacagcc 457681 gtttgtcgat gagggaatta ggcagaaaaa ttaagctgtc gcctccatct gtaacagaac 457741 gggtaagaca gcttgaatcg tttggcatca tcaagcaata cacgctggag gtcgaccaga 457801 aaaaactggg gcttcccgtt tcctgcattg tggaagcaac cgttaaaaac gcggattatg 457861 agcggttcaa aagctatatt caaacattgc cgaatattga attttgctac cggattgcgg 457921 gtgcagcctg ctatatgctg aaaatcaatg ccgaaagcct cgaagcggta gaagatttca 457981 ttaacaaaac atcgccctac gcgcaaaccg tcactcacgt cattttctca gaaattgaca 458041 cgaaaaacgg gcgcggttag agagtgccgc gcgaagtctg ttataataac aggatgagcg 458101 tgaaagaaag agaagtgatc aagcatgtca aaaacagttg tattagctga aaaaccttca 458161 gtcggccggg atttagcccg ggtactgaag tgccataaaa aaggaaacgg ttatctcgaa 458221 ggcgatcaat atattgtgac ttgggcttta ggccatttgg tgacgcttgc tgatccggaa 458281 ggctacggaa aagaatttca atcatggcgc ctagaggatc tgccgattat cccagaaccc 458341 ttgaagcttg tggtgataaa aaaaaccgga aagcagttca atgcagtcaa atcccagctt 458401 acccgtaaag acgtcaatca gattgtcatc gcgactgacg caggccggga aggtgagctt 458461 gttgcgcgct ggatcattga gaaagcgaat gtccgaaaac caatcaagcg gctgtggatt 458521 tcatctgtga cggataaagc gatcaaggaa ggttttcaaa agctgcgcag cggcaaagaa 458581 tatgaaaacc tgtaccattc tgccgtcgcc agagcggaag cggattggat tgtggggatc 458641 aacgccaccc gtgcacttac cacaaaattc aatgcccagc tctcatgcgg gcgtgtgcag 458701 actccgacgc ttgccatgat tgcaaagcgc gaggcagaca ttcaggcgtt tacgcccgtt 458761 ccgtattacg gcatacgtgc tgcagtcgac ggcatgacgc tgacgtggca ggataagaaa 458821 tcaaagcaga cgagaacgtt caatcaagat gtaacaagcc gtttgctaaa aaatctccaa 458881 ggaaagcaag cggtcgtagc tgagctgaaa aaaacagcga aaaaaagctt tgcgcctgcg 458941 ctttatgatt taacggagct ccagcgtgac gcccacaagc gcttcggttt ttctgccaaa 459001 gaaacgcttt ctgtcctgca gaagctatat gagcagcata agctcgtcac atatccgcgg 459061 acggactcta gatttttatc cagtgacatc gtcccgacgt taaaagaccg tctggaaggc 459121 atggaagtaa aaccgtatgc ccaatatgtc agccaaatta aaaaacgcgg cattaaatct 459181 cataaaggat atgtcaatga cgcgaaggtg tcagaccacc acgcgattat cccgaccgaa 459241 gagccgctcg ttctcagcag tctgagtgat aaagaacgaa agctgtatga cctgattgcg 459301 aaacgtttcc tggctgtatt aatgcctgca ttcgaatatg aggaaacaaa ggtcatcgca 459361 gaaatcggcg gagaaacctt tacggcgaaa ggcaaaaccg tgcagtcgca agggtggaaa 459421 gccgtttatg atatggcgga agaggatgat gagcaggagg atgacagaga tcagacactt 459481 cctgcgcttc aaaaaggcga cacacttgcc gtccgcacgt taacggaaac aagcggccaa 459541 acgaagccgc ctgcccgctt taatgaaggg accttgctgt cagcgatgga aaacccaagc 459601 gcgtttatgc agggagaaga aaaaggcctc gtcaaaacgc ttggagaaac aggcggcctc 459661 ggcacggtgg caacgcgtgc cgacattatt gaaaaactgt tcaacagctt tttaatcgag 459721 aaaaaaggcc aagatatttt tatcacatct aaaggaaaac agctcctgca gcttgttccg 459781 gaggatctga aatcaccggc cttaacagca gaatgggagc aaaagctgtc tgcgatcgcg 459841 gccggcaaat tgaaatcggc tgtttttatt aaagatatga aggcttacgc tcaccaaacg 459901 gtaaaagaaa tcaaaaacag cagccaaacc ttccgacatg acaacattac gggaacggca 459961 tgtccggaat gcggcaaaat gatgctgaaa gtaaacggca aacgcgggac gatgctcgtg 460021 tgccaagatc gtgaatgcgg aagcagaaaa acgattgccc gaaaaacaaa cgcacgctgc 460081 ccaaattgcc ataaaagaat ggagcttcgc ggccaaggcg agggccaaac ctttgcgtgt 460141 gtgtgcggtc accgtgaaaa gctctctgta tttgaaaaac gaaaaaacaa agacaaagcg 460201 cgtgctacca aacgggacgt atcctcttat atgaaaaaac aaaataaaga tgagccgatt 460261 aacaacgcgc tggcagaaca gctgaaaaaa ctcggtttgg ataaataata aaaaaacctg 460321 tgcctatcgc acaggttttt tattggactt aggtcctgtt ttcttaatgt tcaaaaaggg 460381 aaaaaaaagc tagcaatctg catttttttt cttttatagt aaatgtactt tgtaacatgg 460441 cagtcatatt ttcgtctata actatttgtg agcgtctgat ttgcttcagg cgacaaaggg 460501 ggatttgcct gtgaggcatg tactaattgc tgtcatctta ttcttcttat ctatcggact 460561 ttccgcaggg tgtgctgaag ctggaaacaa gacccaaaat cagtcggcga cagaagtgaa 460621 tgccagcccg ctccagccgg cggaatattt catctatcac aatttaatga atgacaaagg 460681 gctgatcaaa accgattttt cagaccagcc ttcttacttg tcggaatctc tcggactgtg 460741 gatggagttt ctgctcagca aaaatgacgc accacatttc caggatcaat atcagcatct 460801 gactgattca tttctgatga gcaatcactt ggtgacgtgg aagattcaaa atggccaagc 460861 gagcgggacg aatgcgctga tagatgatat gagaattatg ctgtctcttg accaagccgc 460921 cgcaaaatgg ggccgcagcg actacgcgca aacggctagg gatatcggca cgtctttgaa 460981 gacatacaat atgaacaacg ggttttttac agacttttac gactcacagg ccgcttcaaa 461041 ggatgtgacg ctttcatacg tcatgcctga tgccttagct gtcttaaaga agaatggaat 461101 catagacgaa gaaacagaac agcggaatgc caatgttctc tattcagctc ctttaaaaaa 461161 tggctttctg ccgaagacat acagctcgga gacgaaggaa tacacatatg atagtgaaat 461221 caacctgatt gatcagcttt acgctgcttg gcatttgccg gaaggggatg aaaaagcatc 461281 tgttttagcg gactggatca agcaggaatt tcagaaaaac ggaaagctgt acgggcggta 461341 ttcggcatat acgaaggagc ctgccgtcca atatgagtct ccatccgtat atgccttagc 461401 cgtattgttt ttgacaaaac agcatgaaaa cagttctgtc atcaaagcca tatatgatag 461461 aatgaatgac tttgaaattc atgatccggt gaaatcgtat tatggaggct atatgagcgg 461521 cactcagacg cattcatttg acaatctgct gccgctgtta gccgaaagga agctttttaa 461581 tgaaaatatc attcagtgaa tcacaaaaat tatttgctta tttttcaggg ctcatcgcgg 461641 ccctgtcttt gtttatttat tatgtgtcag cccagcaatc agaaggtgct ctgatccttt 461701 gcatcacatt tggcgtcatc gccgcaggca tctggttcgg cccgatttac gcgctggcag 461761 tgaccttaat cgtactcttt gttctcggca ccttaatgat gtttttccag actggacaga 461821 catcgctctt tccggctgag gaagggctgc gaatgcttgt cgtgtgggga atcgcgcttt 461881 tgctgttttc ttttatttct ggaagaatcc acgatattac agcagagctt cggcgctcaa 461941 tgacacggct tcaatccgaa attaaaagct atgttgctgt tgacagagtg actggttttg 462001 ataacaagca aaggatgaag ctggaacttt cagaagaaat caagcgggcg gagcgctacg 462061 gcaattcttt tgtgtttttg ctgctccata tgcattattt caaagagttt aagtctttgt 462121 acggtgaaaa agaaacggac cgcctcttcc aatatgtcgg tcagcaaatc aggacaagcg 462181 ttcgggaaac ggataagaaa ttccgtccct ctgacgagcg tatcgggatc gtgctgacgc 462241 acacgcctgc tgaacatatg ccggccgttc tgactaagct gaagaaacaa ttggatacat 462301 atcagctgga aaatggaaag tatgtgtcgc ttacgttcca cgtttgctat ttgccctacc 462361 gcaacgatat ccaaacagct gatcaatttt tagaagaact ggaaaacgag atgatgatga 462421 atgaactata aaggaatcac attgctatgc gtcatgatgc ttctattttc agctattgcg 462481 tcttttcccg tttctgcgca agcgaaagat caggatgccg gcattctcat catctactca 462541 accttggacg gcaaagagtc gtcacaagtc aaaatgctcg atttgcttgc gggccacttt 462601 acatcccatg tgacagtcaa aaaagattca gacgttgaag cgtcggattt caaagggaaa 462661 gaccatgtga tttattacgg ccaaacgaaa agaaagctca gccaaaaatt gctgtctctt 462721 atcagcggcg tgaaaaaacc ggttgtcgcc attggctata acgcaggcca aatcagccaa 462781 ttttctgggc tttcattagc ccgcaaagaa aatgtgtttc aggttcacag caggtcagaa 462841 aaggccgatg tgtctctgga aagcgggctt aacgtgctga gtgtatcagg cctgaaagga 462901 acggcgcttt acaccttcaa agcggatgaa ggcacaacgc attcttttat atggaaaaca 462961 aaaaaaggga atgtgtacat tggattaaca aatttgttaa atgacaattt gatcgtggcg 463021 aaacagctca gagaagcttt cggagagaag gcggggacga cgttattgta tttgcgtctc 463081 gaggatatca gcccgatgtc tgatgaaaaa ctgctgcttc aagccggtac atacctgcat 463141 aagcggcata ttccttttat cctggcggtc attccggttt acttgaatcc ggaaacaggc 463201 gacaaagtgt atttgtctaa tcaaccgaag atggtcaagg tgctgaagaa gctgcaaagc 463261 atgggcggca gtatcatagt tcacggctat actcacgctt atcgctacag tgaaacagga 463321 gagggatttg aattttggga tgcaaaggcg gatcagccga ttacatccgg aaatgccgaa 463381 gaccccccgt ccattttgga gaaagaacag gacttcccga acgaacaagc ctatcacagc 463441 tatcttgaac catttcggga aaaggaagaa acgtatacaa aacaaaaact gacgcgtgcc 463501 attgaggatt tgacatcatc gggtctttac ccgctggcgt ttgaagcgcc gcattacacg 463561 atgtccgaat atggctatca aatcgcctcg cagtatttta caagcatttt cggccaggtc 463621 cagctcagca gcacaacatg gaaaacatcc ggtgcacctc cgtttgtgac tgctccttcg 463681 atgctgcacg gaatgacgct ttatccggaa acgatcggct ttgtcgacac atcgaagcaa 463741 aacccgctcg gtgagatgga ggagcatatc tcccagatga ttgattttga aggcggagta 463801 gccggaggat tttatcaccc gtaccttggg atgaaatatc tgcctgagct ggttgatcag 463861 atggaacgca ttccagacag tgaatggctt gatttaaaga aaacgaaaca aaccgtcaaa 463921 acagacaaag tggaaattca tacaagcggt gacggaacga ttcaggtgaa aaacggcgta 463981 agccccattt acgagttttt cgatcatcac cggcaaaccc ctctggaaaa ggcgttatgg 464041 attctctccg ctgttgtgct cttatttgtc atcatgtttg tcagttatac gttttacttg 464101 agagccacat tgaaaaaacg aatttttaag gagagaagaa gccttgggta atacgctgtt 464161 ctttatctcg ctaagtttaa tatgggttat gcttctctac cacatgttcc tcatgcaggg 464221 cgggtttcgc cactatatga ccttcgaacg gaatatcccg aagtggagag aaaatatgaa 464281 ggaactgccg aaggtcagcg tcctcatccc ggcgcataac gaagaggttg tgattcggca 464341 gacgctgaag gccatggtca acctttatta tccgaaggac cggctggaga ttatcgtcgt 464401 taatgataat tcatcagacc ggacgggtga tatcgtcaat gaattttccg agaaatacga 464461 tttcatcaaa atggtgatta cgaagccgcc aaatgcagga aaaggaaaat cctctgcact 464521 taactcgggt tttgccgaat cgaacggcga tgtgatctgt gtgtatgacg ccgacaacac 464581 gcctgagaaa atggccgtgt attacctcgt gctcggcctg atgaatgacg aaaaggcagg 464641 cgccgtggta gggaaattcc gcgtcatcaa tgcggcaaag acgctgctga cgaggtttat 464701 taatatcgaa acgatctgtt ttcagtggat ggcccaggga ggcagatgga agtggttcaa 464761 aatcgccacg atcccaggca ccaacttcgc gatccgcaga agcattatcg aaaagctcgg 464821 aggctgggat gacaaagcgc tcgctgagga tactgagctg accatccggg tatataatct 464881 cggctatcac atccgctttt tccctgccgc catcacgtgg gagcaggaac cggaaacatg 464941 gaaggtatgg tggcgccagc gcacccgatg ggcgcgcggc aatcaatatg tcgtgctcaa 465001 atttttggcg cagtttttta agctgaaacg aaaacggatt atctttgatt tgttttattt 465061 tttctttacg tacttcctgt ttttctttgg cgtgatcatg tcaaatgcga tttttgtagt 465121 gaatttgttt tatgatttgc atttgtctgt tggatttttg gcaatgattc tctggatttt 465181 ggcgtttttc ttatttatga cagaggtcat gattacgttg agcattgaaa aaacagaaat 465241 gaacaagcaa aactttttta tcgtatttct catgtacttc acatactcgc aggcatggat 465301 tgtgcttgtt atctactctt tattcgtaga aatcaagcac cgtttattca agcaagaggt 465361 caaatggtac aagacagaac gatacaatca acataaaagc gggtgacctt tttgaaacaa 465421 ataatgattt ttctcacaag cttcatgctg ctggcgatga ctggacaaac ggctcttgcc 465481 aaagacgtac aggtcagcgg ttcgctcctt gggaaaagca gccaagaaca agccaaacag 465541 caggtgctga caagcgagct gattacactg tatggatcaa aagacagcgc agagctgacg 465601 tatcagatcc cggcaggcgc ctcttcgggc aatcagcaat tggtaatcga atacgaggca 465661 tcaaatcttt taatttctcc atcatcgtta acggttgtca ttgatgatga accggtcaag 465721 acgttaaagc ttgatggtga ttccaaacgg aaaacagtga agctgaatct gaataaaagc 465781 cagtctgcgc aaggctatca caacgtatcg ctgaaattct acggcgtaat gaaagagggc 465841 gtgtgcgtca gacaggatac atcaggcaac tggatcaaaa tttatccgga cagccggctg 465901 acacttgctg acagcagtga agcgaaggga acgtcgctgg accattatcc gtatcctttc 465961 gcccaatctg gaaatacagc ggaagaaaca gctatcgtca ttccggataa cccaagttca 466021 gcagaaatag aagctgctgt taaaacagaa ggctatttga aaacggtgga cagcagtgtc 466081 agtattgcgt atgtcacgga atctgaactg aaaaaaatcg ataagccgac gattgttatc 466141 ggcgtggaca agcattggaa cggcaaagtg aaaaaactgt tgaaacaagc cgggctacag 466201 gcaaaaggag aaaaccttct gcttgcggag cgggtgctga aagcagaggg caaacagcag 466261 ccggttctgt ttgcgcaagc ggcgtccgag gacgcgctca caaaaaaaat cagcgtgatg 466321 acagatcaga catatacagg ccagctcagc ggcgatacac tttcaatcag caagcttcag 466381 cagactgaaa aaaaagaaag cgataagctg acccttgaga attttggagc gggtgatatc 466441 acaattggag ccgacaaaac atcttcagca cattattttt atccggcttc ggctgtttta 466501 gatgaaaacc aatcggcgaa gctgtcgctt aaactgaaaa agtctgaaac gattcaagcc 466561 tcaacggctg aaaacgagtc agcctctcag gctgcagaac tgaaagtgat gatcaacggc 466621 cagccgcact cggtccggct tgatgaatta ggaaaagaag ataaaaacgg attctatcat 466681 gtcacagtga aagtggaccc taagctgctg caaaaaaacc gctacattga tattcagttc 466741 gtcacgaccg gtttaaagga aaacaaccct tgtaacacca ctgatgaaga aaagtgggtt 466801 tttatcgata aaaacagtac attatcatac gccatcaaag gcatgtcccc gtcagcggat 466861 tttcaagagt ggccgctgcc ttacgccgga aaccaggatc aaacaacgtt aatcgtgctt 466921 cctgacaccg taagccaatc gaagctagag gagctttctc tcgtaacaga atcctttggc 466981 aacgaagcac agcattcata tacggtaaag aaatcatctg acgttacagc aaatgatgcg 467041 aaaggacgaa acctcatttt cataggaggg atcaatcaat tttctcttct gaaggagaaa 467101 tcatcagatc tgcttgtgcc gcaggaaaag aacggctcgt ttgatgtatc tagtttcgag 467161 atgctgaatg agacgacaaa acaagtggta tttacccaag catcggtttg ggattcacgc 467221 tatacaatgg ctgtctttgc accgtcaaaa ggagatggca cggctgtcac aaaagagatc 467281 atcagttatc tgaacagcaa cgatgagtcg gcaaccgtcc ttaatgaaac aaacagccag 467341 caggtgttta caaaccacca gcagctcaaa tcggaaacaa acagttccga tgcagaacaa 467401 ccaacacagg atcatagcca gaaatggatg tatattggtg tgctggcact cattatggtg 467461 gttgcggcag tgttcatttg gattgccgta agacgcaaaa aaagaaagac agatacagaa 467521 taaaacagag gcgattttag cctctgtttt tttatttttg gtaagtaaat tccatttgtg 467581 gaacctgtca ttttattttt ttctctcagc caataagcct ctttacaacg tgcgggaacg 467641 ggagtatgat ctcttttaga aaacaaatcg cttaatctga aatcagagcg ggggacccaa 467701 tagaacggct ttttgccgtt ggggtgaatc ctttttaggt agggctaact ctcatatgcc 467761 cgaatccgtc agctaacctc gtaagcgttc gtgagaggag atgaatgaaa cctgtgttcg 467821 atgttatggc acaggggcat ccgtttgcct ctgtgttttt tgttgttcat ttttgaatgc 467881 aaatcgcata cagagacatc atagcagaaa ggactatcat caacatgtga gagcaagaca 467941 ctgatggatg ttttattgtt ttaattgaaa aatgagaaat taaaagggga agacatcgat 468001 gtatcattca atcaaacgtt ttttgattgg gaaaccacta aaatcccaag cagctggaga 468061 gcaaaaactg acgaaattaa aagccttggc tatgctttcc tcagatgcgc tgtcatctgt 468121 cgcatatggg acagaacaaa ttctaatcat tttggcaaca atcagtgcag ccgcattttg 468181 gtactccatt ccgattgcgg ttggcgttct catcttgctg ctcgcactga ttctttcata 468241 caggcaaatt atttacgctt atccgcaggg cggcggggcg tatatcgttt ctaaagaaaa 468301 tctcggtgaa aaaccgggat tgattgcggg cggttcattg cttgttgatt atattttaac 468361 agtagcggta agtatttccg caggcacgga tgccatcacg tcagcctttc ctgcattgca 468421 tgattatcat gtgccgatcg ctatttttct cgtgttagtg attatgattt tgaacctgcg 468481 cgggctttcg gaatcagcat ccatacttgc ctacccggtt tatctgtttg tggtggcgct 468541 tttggttctc attgcagtcg ggttgtttaa acttatgaca ggacaaatag accagccagc 468601 ccatcataca tcgctcggca cacctgtagc cggcattacg ctatttttgc tgcttaaggc 468661 tttttcctcc ggatgctcag cgttgaccgg ggttgaggcc atttctaatg cgattcctgc 468721 attcaaaaac ccgcctgcgc gaaacgcggc aagaacgctt gcgatgatgg ggattttgct 468781 ggcgattctg ttttccggca tcacggttct cgcgtacggg tatggtacgg cgccgaaacc 468841 tgatgaaaca gtggtttcac aaattgcgtc cgaaaccttt gggcggaatg tgttctacta 468901 tgtcatccaa ggtgtcacat cgcttatttt ggttcttgcg gcaaatacgg gattctcagc 468961 cttcccgcag cttgccttca acctggcgag agaccagtat atgccgcgaa tgtttacagt 469021 caggggcgac cgcttaggct tctcaaatgg gattatcttt ttaggctttg cctccattgt 469081 tctcattatc ttattcgggg gacagacgga gcacttaatc ccgttatatg ctgtgggcgt 469141 atttattcca tttacgcttt cacaaaccgg catgtgcatg aaatggatca agcaaaaacc 469201 aaaaggctgg atcggaaaaa tgctgatcaa ctcctgcggc gctctgatat catttatggt 469261 tctatccatt ctgtttgtga cgaagtttaa tgtcgtatgg cctgtgttaa tctttatgcc 469321 tatcgtcgtt ttgctgtttt ttgcgattaa aaatcactat actgcggttg gtgaacagct 469381 tcgcatcgta gacaaagagc cggaagaaat caaaggcacc gttgtgattg tgcctgtggc 469441 cggtgtcacc accgtcgtgc aaaaatcgat tcactatgcg aaatcactgt ccgatcaggt 469501 gatcgccgtt cacgtgtcat ttgacagaga acaggaaaag aaattcgaaa aacgttggga 469561 agagcttaat aacggagtgc gtctcgtgac gcttcactcc tcttacagaa gccttgtcca 469621 tccgtttgat aagtttttgg aaacagttga ggcaaaagcg aagaaggagc agttttccgt 469681 tatggtgctg tttccgcaat ttataacgaa aaaacgctgg cacaccatcc ttcacaacca 469741 atcggccttc ctcctcagag tccggctgtt ctggaaaaag gacataatgg ttgccacact 469801 gccgtatcat tttaaaaagt aaagctctag gaccaaggga atcaccttgg tcctttttag 469861 cgggaaaagg aggtatgggg gtgtatacac aaggtgcttt tgtgatcgta ttgaacgaaa 469921 gtcagcaaat tctgctggtg aaacgaaaag atgtccctct atgggatttg ccgggcggca 469981 gggttgatcc cggggaatcg gctgaggaag cggcagtgcg ggagatattg gaagaaacgg 470041 gatacaatgc agcgctttct gcgaaaatag gtgtttacca aaggccaaag tttcaagatg 470101 aacagcatct gtttttcgga agcattacag gcggacaagc aatggctgac ggcacagaga 470161 cagcgggatt aaagtgggtt tccccggggc gtttgccgct ttttatggtg ccgaatcgaa 470221 aaaggcagat caatgatttc aagaacggcg ctcaagatgt aaatgtcacc gtcaaggata 470281 gcgggttgct cgcggcgatc gacctgttga aaagaagact gggcaagtga ttcaggtctc 470341 cgggttttaa agcctttctc ctgtggtatt gaaaaaagga aaaaggagga tacgttatgg 470401 cacacaaaac tgcaggacaa gcaatgacag agctgcttga gcaatgggga gttgatcatg 470461 tatacggcat ccccggagac agtataaatg agtttatcga agaattaaga cacgaaagaa 470521 atcaactgaa gttcattcaa acccgccacg aagaggtagc ggcactggca gccgcggctg 470581 aagcaaaact caccggcaag atcggagtct gtctgtcaat cgcagggccg ggagcggtgc 470641 acttattaaa tggtttatat gatgctaaag ccgacggcgc ccctgtgctg gcgattgcag 470701 gacaggtttc ttctggcgaa gtcggacggg actatttcca ggagattaag ctggagcaaa 470761 tgtttgagga cgtggccgtg ttcaacagag aggtacatag cgcggaatca cttccggatc 470821 tcttaaatca ggcgatcagg accgcctaca gcaaaaaagg cgttgcggta ttgagcgtgt 470881 cagatgattt gtttgcggag aaaatcaaac gggagcccgt gtatacttca ccggtgtata 470941 ttgaagggaa cctagaaccg aaaaaagaac agctcgtcac ctgcgcccaa tatattaata 471001 acgctaagaa accgattatc ctggcagggc agggaatgaa aaaggcgaaa cgggagctct 471061 tagaatttgc ggacaaagcc gccgctccga tcgttgttac actcccggca aagggtgttg 471121 ttcccgataa gcacccacat tttctcggca acctcggtca gatcggaaca aagccggctt 471181 acgaggcaat ggaggaatgt gatttattaa tcatgctcgg aacgtcattc ccgtaccgtg 471241 attatttgcc tgatgacacg ccggcgatac agctcgattc agacccggca aaaatcggaa 471301 aacggtatcc ggtgacagcg ggccttgtct gtgattcggc tctcggtttg cgcgaattga 471361 cagagtatat tgaacgcaag gaagacagaa gattcctgaa tgcctgcaca gaacatatgc 471421 agcattggtg gaacgaaatt gaaaaagatg agacagaggc aacaacaccg cttaaacctc 471481 agcaggtcgt ggcccgtctt caggaagcgg cagccgatga tgcggtgctc tctgtagatg 471541 tcggcactgt gacagtctgg atggcgcgtc atttcaaaat gaacgcgaat caggatttca 471601 tcgtttccag ctggcttgcg acaatgggct gcggcctgcc gggagcgatt gcagcgagct 471661 tgtccgaacc ggaacgccag gcgatcgccg tctgcggtga cgggggattt tccatggtca 471721 tgcaggacct tccgaccgcc gttaaatata agctcccgat cacagtcgtt attttaaaca 471781 acgaaaatct cggcatgatt gagtacgagc agcaggtcaa aggcaatatc gactatgtca 471841 caaaacttca aaatgtcgac tatgccgcat ttgcagaaag ctgcggagca aagggcatca 471901 aagtgaccaa agcggaagag cttgcgccgg cttttcatga ggcgctgcac tctgaccaac 471961 cggtcgtagt ggatgtcatg attggaaacg aaccgccgct tcctggcaaa atcacctacg 472021 ggcaggcgaa aggctttagc aagtacatgc tgaaaaactt cttcgaaaac caaaaatttg 472081 aaatgccgtc actgaagaaa agtttgaaac ggttatttta aaaaaacagg ggccctaaga 472141 gcccttgttt tttttttttt ttttggaaac aaatgtattt tcagcatgtt tgaattcata 472201 aaatgatcgg tatatgtatt aggaactgat ttcgccatac tcgaaacaga caaaaggaca 472261 aatgcatctt gtttcaaagg aagatgcatt tgtccttgca tgcttattct tatcaaatct 472321 tacagaactc ttctcataat aggttatttt tcttttttct tcagcccgaa gaagaaagga 472381 aaagcagaac cgaccaagaa ggtgccgaat aaaaacatgc cgccgataaa cacgtggaaa 472441 tttgtgtgtc cggccgtaaa cgccgtgatt agggaaatga tactgagcac gatcatggca 472501 atgccgggcg cgactctcat ttttcccttg gatttatggg cagcaacaga acataaaatg 472561 ccgataacaa taggaacaat ccacaaataa aacagaataa atactgacat catcaaaact 472621 ccgatttttc ttctatcata acaaatttct gtcaaaaagg gtatcaatga gcttttgcgg 472681 aaaaataaaa accggcttta gaagccggtt tttttatcga aacgtatcta caattaaaaa 472741 cacattcaaa gcaacgatca atacagcaat cagccaagac accactgtga tccatttggc 472801 gttgatcaga gatcccatga tccgtttatt gcttgtaaac ataataagcg gaatgagggc 472861 aaaggcgatc ccgaaggaca gcacgacctg gctcagtacg agagcggtcg tcggattaac 472921 acctgacgcg atgatcaaga tcggcggaat gatcgtgata aaacgccgta catacagcgg 472981 aatgcggtag ttgataaatc cttgcataat cacgtcgcct gaaagtgtgc cgacagacga 473041 actggataga ccggcaacga gcagcccgat cccgaacaaa gccgcagaca tagggctgac 473101 aagatgtccg aattgctgaa atgcgacgtc gagatcctca acaaacaggc cgtttttgaa 473161 gaataatgcg gcagccacaa tcagcatact tgcattaata gcccctgcaa tcagcatcgc 473221 tattaaaata tcaataaatt caaacctaaa gatttttttc cgttctgcat cagttttgcc 473281 aaccacccgc cgctgtgtaa gggcagagtg taaataaatg gcgtgcggca taacagttgc 473341 gccaagaata cccgctgcaa gaagcacact gtcggtgcca tgaaacgccg ggacaaaaag 473401 gcccttcatc actgacacgg catcaggctt tgcgaaaaag gtctgcaacg caaaggcgat 473461 cacgaccaca aacagcatac cggcaatacc tgcttcaagt gagcgataac cacggcgctg 473521 aagctccaat atcgcgaaag aaccgatcgc cgcaataata gacgcttcaa gcatcggaat 473581 gccgaacagc aaatacagtc ccagagccgc tccgataaat tccgccagat cagttgcgat 473641 aatgaccaac tcgccctgaa tccataatcc gatcgagaca ggcttcggga attcttcacg 473701 ggcaacctca ggcagatttt tgcctgtcgc aataccgagt ttggcggata gggattgaat 473761 taaaagcgcc atgatattgg aaaataagat cacccataag agcatatatc cgtatttaga 473821 acccgccgaa atattcgttg cgaagttgcc gggatcaata taggcaatgg ctgctataaa 473881 tgcagggccg agaaaaggga gcagccctct gaatcctctg attttcccgt caagcgcatc 473941 ttggacggct ttggaacggg gagattgtgc tgtgatgtcc ttgttcatca tgtctcacct 474001 gaattctgtt tgtttttgcc gtacaacaaa gagtttcctt aaggcaaatt attttatcta 474061 catcatatga ccatcccggt ttcttgtcaa ccgaaaatgt tcaaaataca cttctgaatt 474121 tttccctgtt atgtaacatg atatgtaggg attcgtgata aggtcccata taaaaagaca 474181 tcgtttcatt tcgaaacgat gcctcctgta tctaatgagt ctaggcttcc ttccgcagcc 474241 cgcggaatat aaggcccagc aagaacacga agatggctgc cccgatgatg gccgggaaaa 474301 tagcaaagcc ggcgaggctc ggtccccatg tgccaagaag tccgtgccca atccaagcgc 474361 cgatcagccc ggcaatcata gagccgaaaa ttcctcccgg cagccggttt cctacaatgg 474421 cgctcccaat taatccgata acaattgcaa caactaatga aaccaaaaag ctaagcatca 474481 tgatcacctc tcataaatga tttaccaatc aataaccgct cctgatcatt tcgaaacact 474541 tgaaagcata ttcctttatg atcctgtttt aatctttctc tgcacactgc cgtcagctaa 474601 atgaacaatg acctcagtgc ctttatgcgc cgcgatttcc tttgcccgtt caatcgcttc 474661 tttctttgta tccttgattt cagacacacg tttggcgccc tcggctttga ctgcccagcc 474721 ttttttatgc ttaataacat gctctgcttt attcatgagc tcggggccgc tgccgctgct 474781 tggatcagca tcgcgttctg tctcatcatc atgcgtcagg aaatcatcaa tttcatctgt 474841 agaggcgttt tccgcccatt ccttcgcttt gcttgtcgca attggaatcg cgcgcccttc 474901 ctcatagcct tcatcaatca tcgcattcgc aatgtctatc gccttttttc tcaccggctt 474961 ctcaagattt tttaatgaag caggataatc cttcatcgac caaggcatgt ctatcactcc 475021 ttttcctttt ataaaaatgg tacccgcagg tgaaaaataa aaacgcatcc gaaaaaatga 475081 aggtatacta tatagtagaa aaaacggaag ggaagtgcgg gttgggtgcc aacagaacga 475141 aaagaagact tacatcagca attaaaagag atagagaaat gggaaaaaga tcagcaaaaa 475201 gtctggtttt gggaaaagct cagccgtctc ccgtttcaac tcctggacaa gctgacacca 475261 gaattcatcc agaaaaagat cggcaagctc ttggatgagg tcggcagctt tgttcaaaca 475321 ggcggacagt acctgacatc tgaaaaacag attatcagga tgtttcaaaa gaaactgccg 475381 gaggagatct ttgaatcgct ggaggacatc cggaaagcgc ctcttcctgt catggatgaa 475441 attgcggaag gaatgggcaa aaacagaacc aacgcagcaa ccgttcaagg cgcgacaacc 475501 ggtgtgggcg gcgtgtttac gctggcggca gacattccgg cagtgcttgg cttatcacta 475561 aaaacattac aggatatcgc agtcgcatac ggctatgacc caaaggagaa aaaagaacga 475621 gtcttcattg tgaaatgcct gcagcttacg tcggctgatg ttgtcggcaa aagatcgatt 475681 ttgcaggaat taaaacacta cgatcaagac cgtacatata agaatgtcgc ttctcaaatc 475741 caaggctggc gagaagtcgt tttgggctat cgagacacgt ttggctggaa aaaacttttc 475801 cagatagtgc cggttgccgg aatggttttt ggcgccgctg ccaatcgctc aacattaaac 475861 gacattaccg agacaggcat gatgctgtac aaaaagaggc gcattcttga acgactgaaa 475921 gaaacagaac gagagatgga atagcagaaa gcagacggac accgcgatcc gcctgctttt 475981 tttagtggaa acatacccaa tgtgttttgt ttgtttaaaa gaattgtgag cgggaataca 476041 acaaccaaca ccaattaaag gaggaattca aaatggcaga caataacaaa atgagcagag 476101 aagaagcagg tagaaaaggc ggagaaacaa caagcaagaa ccatgacaaa gaattctatc 476161 aagagattgg tcaaaaaggc ggagaagcca ctagcaaaaa ccatgacaaa gaattctatc 476221 aggaaatcgg cgaaaaaggc ggagaagcca ctagcaagaa ccatgacaaa gagttctatc 476281 aagaaatcgg tgaaaaaggc ggagaagcca ctagcgaaaa tcatgacaaa gaattctatc 476341 aagaaatcgg ccgaaaaggc ggagaggcaa caagcaaaaa tcatgataaa gaattctacc 476401 aagaaattgg ctcaaaaggc ggaaacgccc gcaacaacga ctaatcaaaa gcataaaggc 476461 agacaacctg taaataaaaa agcgatccgg cacatcagct ggatcgcttt tttttggaat 476521 cttctcaatt tatgccgcta ttgagataca ataagtgaaa aaggggtttt cgctaatgtc 476581 caagatgcaa aacttgctcg ccatcgcaaa tgaagtcaaa gaaaagcacg ccaatttttc 476641 aatctcagag gtcaacgacc actgcgtgcg ccttgcggtg tttacgggag aatatgactg 476701 gcaccatcac cctgactcag acgaattgtt tattgttctt gaaggggagc tgctgatcga 476761 ttttaaggac aaagaaaccg cggtgctcaa agcaaatgac agcctgctga tccctaaagg 476821 cacggttcac cgcacacgct cttacgtcag aacggtaaat ctctgtgtgg agcataaaca 476881 agccgaaacc gtcatcatag aggagcagcc atgctaatca aaaagatgat atgtgaagta 476941 gatgctgcaa acgctgaagc atttgcaaaa gcgcagtcac agtgggaagc gttatcgcat 477001 ataagcggct ttatcaaaca ggccggcggc tggcgaaaaa cgatagacga gccgctcacc 477061 gcagaaatca tcagtgtatg ggaaaacaga gaagcctatg atcattttat ggagaacgaa 477121 catgacagca tatacgagga aaacgatcag aaggctgtaa ttctttcgat agaggtgacg 477181 gtgtacgaag aggataaacc gttcgttcac gatctgttac ataaccccga tatccggtac 477241 gaaccaaact ggacggttct gaaggcataa tcaaagccca aaacatcatg ttttgggctt 477301 gtctctttac tcgcgtcccg gaagtgtatt atgaacaaaa ggcggtgctg gttttaactc 477361 cggtttttct ccaaacgttt ttgcttcttt cacatattca aaggcttctc cgtccggcgc 477421 tttttcattc agccagtttt gctcggcgct tacttcgcct tcagagaaat tgataagctg 477481 atgtgagaac tcttgttttt cgagcgcttt cgggaatgta cccggcacaa ccggaccttc 477541 ctgtgcttct aattctttaa tggcggcgag ccattggttc tggtgcatcg tgtcacgcgc 477601 cagcaggaag ctgagcatat ctttgacgcc tttgtcatcc gtcatttcaa acaggcgtgc 477661 gacctgcaga cggccctgag attccgcatt caggttggcg cggaagtctg ccagcaggtt 477721 tccgcttgct acgatataac cgccgctcca aggtacgcct gtactgcttt ccggcatggc 477781 gccaagtcct gatacaatcg catggtgagg gttcatgccg cctaggatgg agccgatgac 477841 cggatcttca gcagcttttt cctgctgatc aagaggggca tcctcaagaa gtctggcaat 477901 catcgttgcg atcatttcaa catgcccgag ctcctcagtt gccgtatcca tcagcaagtc 477961 cttgtatttt tcatttcctc ttgtgttcca gccttgaaat aagtactgca tggcaactga 478021 aatttctccg aattgcccgc ctaaaatttc ttgcattttt ttagcgaata atggatctgg 478081 acgatctggt ttagcaggat gctgcagcat ttttgtgtgc ttaaacatgt acccatctcc 478141 tttttcgttt atctcttttt atatttccga tcgatagaaa gataaacgaa aaacagcgta 478201 tcgagatggg aactatgaat cttttcgcag ctccaacagt tcccggatca gctcccggcc 478261 aaagatgggc tcatactgcc ggtaaacagg gtcaagacgc ttcatccatt cttgtttctc 478321 tttatctgac agctcataaa tatgtatagc agaattcttt ttgatttctt ccagctgctc 478381 cttgttcatt tgttcggcat acgtttcatt ccactccgtt gtctccttca tcgcttcagt 478441 caaaatgcgt cttgtttctg gtgtttgcgc cttccagaag tgttcatcag tcatgacagc 478501 gtagccgaga taaccgtggc tgcttattgt caaatagtcc tgaacattat aaaatttttt 478561 agaatagatg tttgaaattg tattttcttc gccatcgact acattgtttt ctaacagctg 478621 aaaggtagaa ttgaaggatt cctgatgagg tgttgcgcca agcagcttga actgatcctc 478681 aatcacatcg ctttgcataa tgcgcagatc ctgccctttt aagtcatccg gtgttttgac 478741 cggcccttga tttgttgtga tttgcttaaa gccgttcgtc caataggcca atcctttcaa 478801 ttggtttttc tttagagaat caaacagctg tgtgccgatg cttccgttca gccctttttt 478861 gacggcgttg taatctgtaa atgcatacgg cagatccagc actccccatt caggcgagag 478921 catgccgagc ttcgatgtgg agggggcgat aaattgaaca tcgccgtttt gcaatgcttc 478981 aatttcttca atgtccgagt acaggcttcc attcggaaat acttctattt ttatttttcc 479041 gcctgatttt tcgttcacca gatcagcgaa tttattggcg gccagccctt ttggcgtatt 479101 ttcagcaacc acgtggctga atttaaacac gatttgatcc tgcaggcctt cctggtcgtc 479161 atcataaaca atctttttat tgccggtatg atcatggaat ccgataaata aagcggttgc 479221 aattccagcg atcatcagtg cgagacatgc aagcaaactc ttcatgaaaa gccctcccct 479281 atgttaagga taatgggggc tatgacattc gtaaagacct gaaaggagaa gctgatgaac 479341 aaaaagaagc tctcaatccg ttggaaaatc acgatcttat cctatatact cgtcattttc 479401 tcctttttga tcggcggcat tgtgctcatc ggcaacattc agcatacaga ggagcgggag 479461 ctgaaaaagc ggctgatgaa tacggcccgg acggtgtcag agatgacaga agtgaaagaa 479521 gccttggcgc gaaaaaaaca aacagaagcg gttcgccatg cggttgaaga aatcaggatg 479581 attaatgaag cagactatat tgtcgtcatg gatatgaatc acatccgata tacgcatcct 479641 gtcagcacaa gcattggcaa gaaatcagaa ggtgcagacg aggaggcagc ttttgcggag 479701 cacatttatt tctctgaagc aaagggcgag atcggcacgg cggttcgcgc tttttatccg 479761 gtaaaggatc aagacctgaa ccaaataggc gtggtgcttg tcggaaaaac gctgccgggg 479821 atcgctgaca tcctgcttca tttaaagcgt gatatcgcct tcatcgttgt gctgacactc 479881 ggctttggcc ttgctggttc ctttttgctg gcccgccata tcaaaaaaca aatgtttcag 479941 cttgaacccc atgagattgt ccgaatgtat gaagaacgga cagcgacgtt tcactcgatg 480001 aatgaagggg tgatcgctat tgacaatcgt ctcgtcatta cgatcttcaa tgaaaaagcg 480061 aaacagatct ttgaagtgca gggggatcta atcggcaagg tgatttggga ggttctcaag 480121 gattcgcgcc tgcccgaaat cgtggagcgg aacaaagcgg tttataatga agaaattcgt 480181 gtcagcggta aggtgatcat gagcagcaga attccgatcg tcatgaagaa aaaagtgatc 480241 ggcgccgttg cgatttttca ggacagaacg gaagcggcca agatggcaga ggaattgact 480301 ggtgtcagaa actttgtgga ggcgctccgt gtccaaaacc atgagcatat gaataagctg 480361 cacacgatcg ccggtctcat ccagctgggg aaatctgaaa aagccttgca gcttgcattc 480421 caggcgtcaa ctgagcagga aaatgtgact gaatttctgc accgctcgat tcaaaatgac 480481 gctgcggcag gccttctatt aagtaaaatc agaaggggaa gagagctcgg cattgctgtt 480541 catatagatg aaaacagcag tcttcagcaa tttcccgagc atgttgatca gcatgatatt 480601 gtcgtgcttt tggggaatct gattgaaaat gccttcggct catttgaaac cgttcaatct 480661 gaagacaaac gaattgacat tagtatcgaa caaacagatg atatccttgc tattttaata 480721 gaagataacg gctgcggaat tgaaccgaca catatgcctc gcctttatga caaaggtttt 480781 acggtcaata aaactggcgg cacaggctat ggcctgtatc tagtgaaaca aatcatagac 480841 aaaggatcgg gcacgataga agttgattca catgcggggc aggggacatc tttttctatc 480901 gtttttccaa tgaaggggga ggaagcacag catggctcgt aaagaatgga aggttctgct 480961 cattgaagac gatccgatgg ttcaagaggt caataaggat ttcattacaa ctgttaaagg 481021 cgttactgtc tgtgcaacgg caggaaacgg agaggaaggc atgaagctga ttaaagaaga 481081 acagccagat ctcgtcattc tcgatgtgta catgccgaaa aaagacggca tcaagacctt 481141 gcaggagatc agaaagcaaa agcttgaagt ggatgtcatt gtcgtctccg ctgcaaaaga 481201 caaggaaacg atctcactca tgctgcaaaa cggggcggtt gactatatct taaagccgtt 481261 taagcttgag cgaatgagac aggcactcga aaagtacaag caatataaac aaaaaatcga 481321 agcgaatgat acgctgtccc aggaacagct cgatgcgatc ctgaatattc cgcagcaggc 481381 cgtacaggat ctgccgaaag ggttgaatca cttcacgatg aatgaagtca ctgctttttt 481441 gaaacagcaa accgcatccc tttctgctga agaggttgcc aaggcgctcg gcatcgccag 481501 agtgacagcc agacgatatc ttgattactt agaaaaaacc gggatcatca aattggacgt 481561 tcaatacggc ggagtcggcc ggccggtcaa ccgctacgtg ttaaaaggat aaacctgaga 481621 ccaaaaagac caaaatgtcc gttatgatca taaacttccc cagactgtat gaaaacgcta 481681 tcattctagt aagaaagaca caaaaggcga ataggacagg gggatgaagg atatgaaact 481741 gtttaaaaat ttaacagttc aggtcataac cgcggtcatc atcggggtca ttgtcgggct 481801 ggtctggccg gatgtcggca aagaaatgaa accgcttggt gatacattta tcaacgctgt 481861 taaaatggtg atcgcaccaa tcattttctt cacaatcgtt ctcgggattg caaaaatggg 481921 cgatatgaag aaggttggaa aagtaggggg aaaagcgttt atctatttcg aggttgtcac 481981 caccctcgca ctcattatcg gtttatttgt cgtcaatatt atgaagccgg gtgcgggtct 482041 tgattacagc aagcttgaaa aaggagatgt atcacaatac acgcaaaatg gcggtcaggg 482101 aatcgactgg attgaattta ttacacacat tgttccgtcc aacatggttg atgccttcgc 482161 aaaaggggac attttgcagg tcttattctt ttctattctt ttcggagtgg gtcttgcggc 482221 attaggcgaa aaaggaaaaa gcgtcattga tttcttcgac aaggtttctc acgttttttt 482281 caaaattatc ggctacatta tgcgtgccgc gccaatcggg gcattcgggg cgatggcgta 482341 tacaatcgga cacttcgggc tcgattccat caaaccgctg gcaagcttaa tgatgtctgt 482401 ttatattacg atgttcctgt tcgtatttgt tgctttaaat atcatctgca agctttacgg 482461 attcagcctg tggaattacc ttcgcttcat taaggatgag cttttgatcg tgcttggcac 482521 aagctcttcc gaatcggtgc ttccgcgtat gatggataaa atggagcgct acggctgttc 482581 caaatccgtt gtcgggcttg ttattccgac gggctattcg tttaacctcg acggcacatc 482641 catctattta tcaatggcga ctgtcttttt ggcacaggtg tttggagtag acctcagcat 482701 cggccagcaa attacgatta tcctcgttct gatgctgaca tcgaagggag cggcaggtgt 482761 gacgggaagc ggatttatcg tccttgcctc aacgctgtca gcgctgcagg tcattccgct 482821 ggaggggctt gcactcctgc tcggggtcga ccgtttcatg agtgaaggaa gagccattgt 482881 gaacctgatc ggaaacggaa tcgccacgat cattgttgcc aaaagcgaaa atgaatttga 482941 tgaagcaaaa agcatagagg ctgttgaagg catgaaaaaa atgaaaacag cagtctgaaa 483001 aaagaacggc ccatccatgg gccgtttttt taattgttta agaattatta aggtaaggac 483061 agagacctca gcattttttt gttatataat ttacaaatgg atactatatt gaatgaagga 483121 cgtttgtcct aacaggagtg tataaatggc cgctttagtt aaattttttc agcacccggg 483181 agtaaggcgt ttctccatct ttgtcgtgtt aactggtgtg ttatatctat ttaagagcat 483241 gatcaactta atattgctta ccttcatttt cacatttcta atggatcgtt tggagcttgt 483301 cgtgcggcag tttgtaagcc agttcttccg cgtgagccag cgggttgtca ttacgtttct 483361 ttacatgttg ctggctgtgc tgcttacagt cgggggcttt gtgttttatc cggtcgtcgc 483421 ggcgcagatc cagcagctgg taaagcagat taaacatatt gcgtatcatc ctgacagcat 483481 ccctttcttt gatgagatca ccagtgtctt cggagatatt aacatcagtt catatgtcaa 483541 agagggcttc aatgtagtgt atacgtatct ggccgatatc agcacattcg gcttgcaggt 483601 cgtgatggcg ctcattctta gcatgttttt cttatttgag aaaaaacggc tttctgaatt 483661 catggcgaaa tttaaaacga gcaaacttag ggtcttttat gaggagattg cttttttcgg 483721 aagcaaattt gcaagaacgt tcggcaaggt gctcgaggct caatttatca ttgcgctcgt 483781 caactgtatt ctgacgttta tcgcgctttg gattatgcat tttccgcagc tgtttgggct 483841 ttcgattatg gtgttcttcc ttggattgat ccctgtagca ggcgtcgtca tttccctgat 483901 tccgctcagc attatcgcct acagcactgg cggtggaatg tatgtgctct acattgtcct 483961 tgtcatattc gccattcatg cgatcgaaac ctatttctta aatccgaagc tgatgtcggc 484021 gaaaacagag ctgccaatct ttttcacctt cacagtactc attttctctg aacacttctt 484081 cggcatttgg ggtttaatta tcgggattcc gatctttgtg tttctccttg atattctgga 484141 tgtcaccaac aaggaagata ggtctaaagg accccgagag aatagcgata aaaagtagtt 484201 taaaatcgaa taatgagtgt gcctcgatct gccggcctgc ctgttcaggg catggaatta 484261 agactcggaa tcggagcttg gcattgcctt gcacagtggt gaacacaaca ggtgacaatg 484321 cttgtcatca gtacggaaac tgaaaagaac aaacagtcgg agcaaacgct catcatcggt 484381 ttaaccaaac atttggaagc aacaaatgct ataatacaaa cagtgcctaa tgttgggcac 484441 tgtttatttt ttgtcgaaaa aggaggaagg ctttatggct gagccgattt tacatattga 484501 aggcctcgat aaaaaaattg ggtctaaaca gattttaaaa cagatcagca tggacgtcat 484561 ggagggtgaa atcatcggcc ttctcggtcc gaatggttcc ggaaaaacaa cactcatccg 484621 tatcatcgtc gggctgttga aacaaaacag cggaagcgtg acaatcagcg gattccagca 484681 tgatacagag tttgaaaaag cgatggaagc ggttggagcg attgttgaga accctgagtt 484741 ctatccgtac ctgacaggct gggaaaacct caagcacttt gcgaatatgc acaaaaaaat 484801 agcggatgaa cggcttgatg aagtggtgga acgtgtcggg ctgacgtcag cgattcatga 484861 taaggtgaaa acctattccc ttgggatgcg ccagcgtctg ggaatcgccc aggcaattct 484921 tcaccggccg aagcttctca ttctagatga accgacaaac ggcctcgatc ctgcggggat 484981 gaaggatttt cgggatcata ttaaggaact cgcagaaatg gaaggaacag ctgtcctgtt 485041 cgccactcat ttattgcgcg aggttgaaga cttgtgcgac cgtgtcatca tcattcaaaa 485101 aggtgagatc aaagcggaag tcagcttaca aggaaccgat caaaccacag aaaaagcgat 485161 tatagaagtg cagccgcaag aaaaagcgct caattggctg acaggcaatc aatatcaagc 485221 tgagagccaa gacgggacga ttgtagttga ggtggcaaaa gaaaacatac cggagctgaa 485281 ccgatcactt gtcggacaag atctgaatgt attttccatt acgccttaca cgcagtcact 485341 ggaagacgaa tttataaaag cgacaacagc tcatcaagag gagggagaag agcttgtcta 485401 aattaatttg gaatgaacat atgaaacttt ttaatcggaa ggtcactttg gtttctctta 485461 tcctgatggc tgtctttcaa ttcttcatgg cattgatcat taaacggatt gtcatcagtg 485521 ccggaacaga tgaaaacttc atcggctatt tatcgtatac accgagcctg aacattttgc 485581 tgcaggcttt aacgatcgta attgcagcaa caattgtttc gatggaattt gataaaaaga 485641 cgatcaaatt tttgctcatt cgtccggtta aacgccaaaa ggtcttttgg tcaaaattaa 485701 tcacagtcgt gatggtcagc ttctatttgt atttggcata ctacattctg gcattattat 485761 tcggtctctt gttttttggc acatcggtga ctgcggaatc aaagacattg ctggtcaaca 485821 ccttggcgct gatcgggtca aactggcttg aagctgtaat gatgggatta ttcgggctgc 485881 tttgttcttc gctgttccgc aatagcgcgg tagcagttgt tgtttctttt gtcgttttat 485941 acggagcgag tacacttgtt cagctcatga agttgtttga aaacaagtgg ggcagctttt 486001 tgctttttgc gaacactgac tttacgcaat acagaagcgg agagacagcg ttgttttcag 486061 gcatgacgcc attgttttca attggaattc tcatcataca tgccatattc ttcatcgttg 486121 ttggctggtg gtgcttctgt aaacgggatg ttcgggtcta aaggcaagga atgacatttt 486181 tgtgaaaaag ctcacgtaaa tcaatatcat ttgatatttt ggtttatact aaaggtactg 486241 acggaggtgt ctcgattgag gaactttatt accgctttac cgatcgtatt gctgcttgga 486301 ttctcatttg tgtcattcat gtttcagttt gaacatcttg tttatttcag gctcgcgctt 486361 gggttgtttt ctctcgtggg actgtacatg atatataaaa tgaagacggg catccgctat 486421 tttatcatct atctgtatgc cagctggatt gtgttggccg cagtgaccgc ttttgaagag 486481 ccgattttct caagcttttt ctttggcggc ctggtgatga cgatgggtta cctgacatat 486541 atgctgattt atctcggcat gaaacaagac cgggatgcaa atcctgtgta atcgcgctgt 486601 tcccttgggg aacggcgtgt ttttctatac tgggcaaaag gttaacagtt gcggaaaaat 486661 ggcaggaaat ctataataca tattaaattt atcggaatta aaactggggg gctgccggat 486721 gtcattattt atacaaaacg atcaacagcg gcaatggatg gagaaaatcg gacggattgc 486781 ggatgaattt cagcaaacag ctgctgaaga tgacgaacag ggacgttttc ctgcagagaa 486841 aatacaaaaa ctgcgtgatg ctgggtatac agcattaaca ttgccggcat ctcatggcgg 486901 agggggcatt tctgtttacg atatgctctt gtttcaagaa cggcttgcac ggggagatgc 486961 tccgacggct cttagcatcg gctggcattt gagcgtgatc ggggagcttg gagaaggcaa 487021 cagctgggat gaagacgtat ttgcatttgt tgccaaggaa gtccaaaacg gagccgtcat 487081 taacagggcg gcgactgaag cgaaaaccgg aagcccgaca agaggagggc gtcccggtac 487141 acacgccgtc aaaaaggatg gcaaatgggc agtgaacggg agaaaaacct ttacgacgat 487201 gtcacaagct ctggattatt ttttagtaac cgcatggatt gaggacaaac aaacaacagg 487261 cgtgtttctc attcataaag atgatcccgg cttgtcgatt gaagaaacgt gggatatgat 487321 ggcgatgcgg gcgactggga gccatgacct tgtactgaac gaagtaatgc ttgatgagaa 487381 taagctggtg gaactgcttc aagggcctcg tggagctaag ccgaatggct ggctgcttca 487441 cattcctgcg atttatcttg gtgtggctca agctgctcgt gactatgcag tgcaatttgc 487501 atctgagtat tctccaaaca gcttgaatgg accgatcaag aatgtcccgg ccgtacagca 487561 aagaacaggc gaaatggagc ttgaactgct caatgccaga cactttcttt tccatatcgc 487621 tcaattgtat gacgatccgg tgcggcgtcc acacttgacc agcgagctcg gtgcggcgaa 487681 acatatcgtc acaaacgctg cgctgtctgt tgttgataaa gcgatgagaa ttgtcggggc 487741 caaaagcctg gaacgaacca acccgcttca gcgctattac cgtgatgtgc gcgccggtct 487801 tcacaacccg ccgatggatg acgccgtgat acacaagctg gcagctgaag cgtttgagtc 487861 ataaaaaaaa gagccttacc ggctcttttt atgtattgtt ttgctcttgc agattttttt 487921 gatgcttgcg gtcgatcctg tcataaataa cgttcatcag ctttggattg cccataatcg 487981 cctctttgtt ttcctggatc agctgttggt aagttttcac tttacgcttc ggcatgctcc 488041 ggcgccctcc tgacatgttt gtattcactt tctaactccg tcagcgacaa ttcatacaga 488101 tgacgctttg actttttgta tataccattc tgtattaaca gatgaatgag ctgttttttt 488161 ctgatttctg cagactgagg tgtcattgtg tcaccaacct ccaatcaaac gatattgata 488221 atcattatca attaacttca gtatacaatg tccgcaatag cctgtaaaga tgaaaagagt 488281 cctattcttg gccaatttac aaacattcaa caaatcgaca aaaagtttcc cgggcaataa 488341 tttgctgtcg aaatattccg cttcattgaa cgcaccctgc tatttttcat gttttgaacc 488401 atactatgta atagaatgga ggctggtatt caatggagcg gacagaaaat ctgaaaaagg 488461 gagaaaaagg ggcgctcctc aatatttttg catatgtcat ccttgctgtt gtaaagctag 488521 ttatcgggat tctatatcat tctgaagcgc tgagagcaga cgggttaaat aatggaacag 488581 atattgttgc gtcagtagca gtgctgatag gattgcggat ttctcaaaga ccggctgaca 488641 gcgatcatcc atacggccat tatcgggctg aaacaatttc gtctcttgtt gcgtctttta 488701 ttatgatggc agtcggcatt gaagtgttaa tcggcggagg aaaagcgatt gcgggcggca 488761 caacggaaac gccaaatctt atcgcggcat ggacggcgtt aggcagtgct gtgtttatgt 488821 atggcatcta tttatataac aaaaggctgg cagcgtccat taaaagctct gccctgatgg 488881 cagcggcaaa ggacagcagg tcagacgctt ttgtaagtgc cggcgcgttt atcggtgttt 488941 tttcgtccca gctgaagctg ccgtgggttg atccggtaac ggcttttatc atcggcatca 489001 tcatttgcaa aactgcgtgg gatatcttta aagacgcttc acattcctta acagacggct 489061 tccatttaaa agatcttgag ccttacaaac agaccgtcgg caggatcgaa aatgtgcatc 489121 gcctaaagga tgtgaaagcg aggtatttag gcagtacagt tcatatcgag atggtgatta 489181 cggttgatcc gaagcttaca gtagaagaag gccatggagt ggcggatgaa gtagaagaca 489241 aaataaaaca tgaacacgat gtcactcatg ttcatgttca tgtagagcct gacgacataa 489301 aataaggctg tttaacgaat tagcttatat gttcagataa aaattcagtc acttcttcag 489361 gcgttttggc attggcgctg tgaaggtgag ctgttttttc accgttcttg aaaataagca 489421 ggctgggaat gcccattact tggtattttt cagccaggtc aggaagctcg tccttattca 489481 gctcatacca gtcgttttgg ttgtattctt ccaaaatatc gccgatgaac atattcatgc 489541 gtgtgcagtc tgggcaccaa tcagcataaa actttacaat gatttcttta tcagattgaa 489601 tcagttcatt aaattgttcg tttgttgtga tttttttcat atgtcacatc tccttttcaa 489661 tgccatttta atataaaata aaaaggaatt acatacaaat gcattcaaca tcagcatgcc 489721 caaaaataat tagatcattt tccggtgaaa atgataagat agtaaagatg aattgtagtg 489781 gggggagtat ccattgaaaa caagtctagg attagtgtac ggaggaaagt cggcagaaca 489841 taatgtttcc ctgcagacag ctctggctgt aatcaaagcg ctaaatactg agaagtttga 489901 tatacatccg atttatataa cagaaaaagg cgaatgggtt agaggcgccc gtttaactga 489961 acctgtttca aacgtgaaaa tgcttcaatt tgagcaagga ggcagtgctt tttctccagc 490021 tgccctgaac caggagatgt ttccgcagga agcgtcacag caaaatgaag ccatcgacgt 490081 cgtattcccg ctcctccacg gaccgaacgg agaagacggt acgatccagg gaatgctcga 490141 gctgttgaac attccttatg tcggcaacgg agtgcttgct tcctcagctg gcatggataa 490201 agttgtcatg aaacatttat ttgcgcaggt tggccttgct caggctaaat acgcagcttt 490261 ccttaagaaa gactggactc gttctccgaa agaaagctgt gaggaggttg aacaggaatt 490321 aggctaccct tgcttcgtaa aaccggcgaa cctcggctca agtgtcggaa tcagcaaatg 490381 ccgaaaccgt gaagaactgc aaaaagcgtt tgagcttgct ttccaatatg accgcaaagt 490441 cgtcgttgaa gaaggaatta acggccgcga gatcgaaatc ggcgttcttg gaaatgatga 490501 tcctaaatgc tctgttgtgg gagaaatcgc accgaagaca gatttctacg attacaaagc 490561 gaaatatgag gatggagata ctgatctgat gattccggcg attgtgactg atgaggaata 490621 cgcaacaatc agtgatatgg cgatcaaagc gtttaaagcg atcgacggtt caggactcgt 490681 cagagcggac tttttcctga cagctgacgg cgaagttctg atcaatgaag tcaacacaat 490741 gcctggcttt acacctttca gcatgttccc gttgctctgg aaagaagccg gagtggaata 490801 tgctgacctg attgaacagc ttgtggagct tgcaaaagaa cgccacgctg aaaaacaatt 490861 gattaagcat acattctaat gaagaaggac actgccggta aaagggcagt gttttttccc 490921 gtatatacaa aagaaagaga gggaccttac ttgattaagc gaacagtaaa aaacattgcc 490981 gaaatggtta aaggcacact agcaaatccg caatatgaac aaacagtcat tcatggagtg 491041 gcaaccgata caagaaaact ggaacaacat cagctcttta ttccgctgaa aggggaacgt 491101 tttgacggcc actcttttgt ggagcaggcc tttgaagctg gtgtagcggc tgttctttgg 491161 gatcggtcag taccaaatcc gcccgagaat cacgccgtca ttttagtgga cgataccctt 491221 actgcacttc agcagcttgc aaaagcttat ttgcaggagc ttggcacgcg tgtcatcgga 491281 gtaaccggaa gcaatggcaa aacgacaaca aaagatatga ttcacgccgt attggggacc 491341 cagtaccgtg tccacaaaac tggaggaaac ttcaataatc atatcggttt gccgctgacg 491401 gttttagcga tgcctgaaaa tacggagatc gccgtattgg agatgggaat gagcgccaaa 491461 ggagaaattg acctcttgag ccgactggca aacccggatg cggcagtgat tacgaatatc 491521 ggcgaatcgc atatgcaaga cctcggctct agagagggca tcgcggaggc gaagcttgaa 491581 atcataaacg ggcttaaaga agacggagtg ctgatttata tcggggacga accgcttctt 491641 caaaatgcat acagctgcca gacgaaaacg tacggtacgg gaacgcataa tgattatcag 491701 cttcaggatg tcagccagag tgaggaagga acccatttta caatcaaagg gatagaaaac 491761 acgtttttta ttccaatact cggcaagcac aatgtgatga acgccatggc tgcaattgct 491821 gcaggggctt attttggcat cgcgcctgag gatgcggcaa aaggactgag cggcctaaag 491881 gtaaccggga tgaggcttga actcatcaaa acagacagcg gcctttcgat aatcaatgac 491941 gcttataatg cgagcccgac ttccatgaaa gctgcaattc aattgacaga aagccttgaa 492001 ggctacggca aaaaaatgct cgtgctcggt gatatgcttg aactcggcga tcttgaagaa 492061 acgttccata aagagtgcgg cgctgtgatc agccctgata aaattgaccg cgtctttacg 492121 tacggaaaac tgggagcttt tatcgcggaa ggcgccctga aacactttga gaaagaccgc 492181 gtcagccatt acactgagaa aaaagatctc cttcaagctg tgaaggaaaa cgcatcaaaa 492241 ggcgatttga ttttattcaa agcgtccaga ggtatgaagc ttgaagaaat cgttaaagat 492301 ttaatagaga gcccgctttc ataagaaaat attttgcgaa aaaacgcata ttgcatcata 492361 aaataacctg atatgcaaac actaatgtat gccggccgaa aattatgtat atctggccgg 492421 ctgcggctat gatacaatat atataggtta tttcgcgata cgaacatatt cgtccggact 492481 tttcatcgtg acccgaagtt ctccgctgga ttcttgggag cggatggagc agcagccggc 492541 atattcgaga tgccgatctg cttctcatct tattgaaaaa caaatagtgt aatggtaaga 492601 taaaacttaa agtaattcgg gctttgtata cggatggatc ctgtccttct tgtctaaagg 492661 gcagttttat aagtggtaaa tcacgacatt actgaaacag caattagaag gagtttgaat 492721 aatttgacta taacgtttca agattttaat ttaagttctg atctcatgaa agcaattaat 492781 cgtatgggat ttgaagaagc aacaccgatt caggcacaaa cgataccgct cggactttca 492841 aataaagacg tcattggaca agcgcaaaca ggtacaggta aaacagctgc gtttggtata 492901 ccccttgttg aaaaaattaa ccccgagtct cctaatattc aagcaatcgt aatcgcgcca 492961 acccgtgaat tagccattca agtatctgaa gaattgtata aaatcggaca agataaacgt 493021 gcgaaggttc ttcctattta cggcggacag gatattggac ggcaaatccg ggcgttaaag 493081 aagaatccga atattattgt cggaacacct ggacgtcttc ttgaccacat caaccgccgc 493141 accattcgtt taaacaatgt aaataccgtt gtaatggatg aagcggatga aatgctgaac 493201 atgggattca ttgacgatat tgaatctatc ctttcaaacg tgccaagcga gcatcagaca 493261 cttctgttct ctgccacaat gcctgcgccg atcaaacgca ttgcagagcg cttcatgact 493321 gagccggaac acgtaaaagt aaaagcgaaa gaaatgacgg tttctaacat tcagcagttc 493381 tatttggaag tgcaagaacg taaaaaattc gatacactga ctcgccttct tgatattcag 493441 tctcctgagc ttgcgatcgt attcggacgt acaaaacgcc gtgtcgatga gctggctgaa 493501 gctctgaacc ttcgcggata tgcagctgaa ggtattcacg gtgacttaac gcaggcgaaa 493561 cgtatggttg cgcttcgtaa atttaaagaa ggcgcaatcg aagttctagt cgcaactgat 493621 gttgccgctc gcggacttga tatctcaggt gttacacacg tatacaactt cgacgtgcct 493681 caagatcctg aaagctacgt tcaccgtatc ggaagaacgg gccgtgcagg aaaaacaggt 493741 atggcgatga cgttcattac accgcgtgag aaaagcatgc ttcgcgcaat tgaacaaaca 493801 acaaaacgca aaatggaccg catgaaggag cctacacttg atgaagcgtt agaaggtcag 493861 caacaggtta ctgttgaacg tcttcgcaca acaatcagtg aaaacaacct gaacttctac 493921 atgacagcgg cagctgagct gcttgaagat catgatgcag taacagtggt tgcggcggct 493981 atcaaaatgg ctacaaaaga gccagacgac acaccggttc gcttaacaga cgaagcgccg 494041 atggtcagca aacgctacaa gaaccagcgc tcttctaaac gcagagacgg tcaaggcggc 494101 ggctaccgcg gcggaaaagg gaaaagcaac aaccgttctt cctatgacaa aaagcgttca 494161 aacgatcgcc gttcttcagg tgacagacgc cagaaaaaat cttactaatt tgatcgattc 494221 agagcccaaa acatgatgtt ttgggctttt ttatgttcgt gatttgttat tcagcaaact 494281 ttcagctgac ggaagccatt tttctctgta tgcttaagaa tgaaaccttt ctgtaaaaga 494341 gacgtataaa taacgacgaa aaaaagggag gtaggtattt ttgagagagc agccaaaaaa 494401 ccaaatcagt ccagacggat taaaggtttg gcgacttcaa gagatcatca tatccgctgt 494461 ttgcttgctt attgtcattg cagttgcagt gttaagctat tattttcatt ggccgtactg 494521 gatcagcggc gtgctcggcg ctgtttggct gctgggatcg attgtgacgg tctttatcat 494581 tccgaaggtc cgtcataagg tgtggcgata tgaagtccat gaacatgaaa tagatattca 494641 gtcaggtatt tttgtggtga cacgtgtgat tgttccgatg gtcagagttc agcacgtcga 494701 tacgtcacaa gggccattat taaaaaaata caacctggca acggtgaaaa tttccacagc 494761 cgcgaccgtt cattcgatcc ccgctttaga gatggaggaa gcggatcggc taagagactc 494821 catttcccgt ctggcgaggg tgactgacga tgatgtctga accgaaacgc ctgcacccgg 494881 tggcagtcat tttgaattta tgccatacca ttattcaaac gataaaaaat atcattctgc 494941 cattcttttt tgtgtatatt gtcaattcaa accatactgt ccgtttttac ggagccattg 495001 cgctcggtgt gctgttcatc tggcttgtag cggcaagcat tatcaaatgg agaaggttta 495061 cctatcgaat tgaagatgat gaatttagaa ttgaagaagg cttatttgtt acgaaaaaac 495121 gatacatatc gattgatcgg attcaaacaa tgaatacgag cgcgggcctt gtccagcaaa 495181 tctttaagct tgtgaagctg caaattgaaa cagcaggcgg aggcaaggag gcagaagccg 495241 ttctttctgc tatttctgtt gaagaagcgg aacgcatcaa agaagctgtc tttaagaaaa 495301 aagcgcaaag acgagaaaat gaacttgatg aagaacggct tgaagctgaa gaggagttgg 495361 atccgtccgt tgaggtgcaa gagcactatc gcatgaacgc gaaagaattg ctcatggccg 495421 cttctacctc cggcggaatc ggagtcatta tctccgctgt atttgcactt atttcccagc 495481 ttgatgaagt gctgccgatg gattggttat tcgataaatt ttccttcctt cagcacgcca 495541 gcatcggtat ttatgcggta ctcattttta tcggtttatt tatcgcctgg attttcagca 495601 tcgcgggcat gatgtttaga tacgcgaact ttcaaatcat aaaaaaagag caggaactgg 495661 tgatttcaag gggaattatt gaaaaacatc aagtcacgat tccgctgcga aaaatacaag 495721 ccattaaaat caaagaaaat atcattcgcc agcttttcgg ctttgtaacg gtgtccatcg 495781 tcagcgcagg aggcggcgac cgggaaaaag aagaaggcgc tttgaccatt ctctttccaa 495841 tgattcataa aaaaaagctt ccgcacatgc tccgaacatt tacgccggaa tacacgctgg 495901 aagaaaactg ccgccgcctg ccgcggcgcg cgttgaaacg ctatttgttc cgttctgtca 495961 ttttttcact ctttttgatc atcccgttat gtatcttctt tcagccatgg ggctatctgt 496021 cagtgatcct gctgccgata gaattgctct tcggctatct cgcgtataaa gaggctgcat 496081 ggacgatcaa cggggaccgt cttcagctga cgtctagatt tataggcaga acaaccgcca 496141 ttgtactgaa aaaacgaatg caggtctgca agttcagcca atcctatttc caaaagaaag 496201 gccgcttgta taccatttct acttcggtga aatcatcgag ccatatggaa gagttaacgg 496261 tgagggacgt aggtgaagag gatgcagcct tcattttaaa gtggtactca tatgaaaaag 496321 cggacggtta ataccgccgc tccagcgtgt cggcaaaccc tcgcattcgt tgtcaggact 496381 gcgcttcggt gctcaatgcg aagtggatca acggctaaat tctcaggcgt cctgcctaaa 496441 cgccgtcgtc atcacatcct gtgaaagtcc gctcctatgc tcgtccttcc tagacttcat 496501 gggttttcaa tcacgctgaa aagatgacaa aatcctaaaa tgaaaaccat tttaggattt 496561 tgtcaacaat ctgaagcggc ggttaatacc gccgctcttt tttttgcacg cataaaaacg 496621 aaagaagaaa cccgccgcat agtccaaaca aatgggccat catgttaata ttggagttga 496681 taaacgacat gagaacggca aatgcgagca gtgtgatgat cattttggaa tgctcctgcc 496741 caattaactc attgcgaaaa agaaccataa acaggtatac gccaaatagc ccgaaaatgg 496801 cgcctgaagc cccgacatgc acgtaatcaa gcggctctgt aacataagtg ccgatattgc 496861 cgatgatgcc ggagccggcg tatacaagaa ggaaacgcgc ttttcccagc atgcgttcca 496921 aagccggggc aaataaaaag atggacatgg aattaaacag cagatgtgtg aaaccggcgt 496981 gcagcaaaat cggtgtgata agccgccacc attcaccgtt tgcgacacct agattatagc 497041 ctgtgacggt atccctccat aacacgactg aatgggcagg aagtgaaaaa aacagccaga 497101 gaacagcttg caaagccaat ataaaggtga caacggggta aagcctgata aatgtttgaa 497161 aattttcagt ccgtataaac attccgagcc ccttttcttc attttggtat atctatagta 497221 acacgtttat gagacaaacc atttaaatag tacgtacgca aaggaggtta tcatacatga 497281 tttacggcat tgggctggac attaccgagc ttaaacggat cgcctctatg gctgggcgcc 497341 agaaaaggtt tgccgagcgg attttgacgc gaagcgagct tgaccaatac tatgagcttt 497401 cagagaaaag aaaaaacgaa tttctcgcgg gcagattcgc ggcaaaagaa gcgttctcga 497461 aagcatttgg caccggcatt gggaggcagc tcagctttca ggacattgaa attaggaaag 497521 accaaaatgg caagccctat atcatttgta cgaaactgag ccaggccgcc gttcacgtat 497581 cgatcactca tacaaaagaa tacgctgccg cgcaggttgt gattgaaagg ttgtcaagct 497641 agtctgcata ttagggaaac cccactcata tatttgatag tgcattaagg gagacaagtt 497701 gtttgaggct tttatggtac gcatctgttc tgcctaaacg tgtaccgagc gtaccgttaa 497761 agtcaaacaa gcgatttctt ccttttacat caattgagaa aaaggggttg aaaaaggtga 497821 gaaaaagctt tgttttgctt ttaacgggac tgcttgctgt tcttattctt tctgcctgcg 497881 ggcaaaaaac acagcaagat attgtggccg ggttagatga aaaggcgaaa gaatacacct 497941 cgtacaaagc aaaagcgaaa atgaccatcg agacagggag tgagcctcaa gtatacaatg 498001 tggaaatctg gcacaaaaag ccgtctctgt acagggttta tttagaaaat ccgaaaaagg 498061 accaaaacca agtcatttta cgaaatgaaa acggagtatt cgttctcacg ccgtctttaa 498121 ataagagctt cagatttcaa agcgattggc cgaacaacag cagccaggtt tatctgtttg 498181 aatcgctcgt aaaggatgtt caaaacgatt cggatgcagt tttcacagcg aaagaaaaga 498241 aatacgtatt tgaaacaaaa acaaactatc agcataacaa aatgctgccc acgcaagaaa 498301 tcacatttaa caaaaaagat atgagcccgt catctgtcaa agtgatggat actgaccgga 498361 aagtgatggt caaagtagaa ttcagcagct ttgaatttaa taaacaattt gataaagaat 498421 catttgatga aaagaaaaat atgacccttt ctcaaatgga tgtcgccaca agcgcaaagc 498481 cttccgatac atttgcggtc aaaacgccgc tggaactgcc gcttggcgtc aagctgcttg 498541 aagaaaaaga tatatctact gaagacggga agcgcatcat catgacgtac ggaggagaaa 498601 aatcatttac gttaattcag gaaaaagccc agattgccaa ggcttcctcc tccgttacgc 498661 tgaacggcga accggtaaat ctcggctaca ccatcggcgc cctgtcggat gcatcattat 498721 catggacata tgacggcgta gattaccttc tctcttctaa agatctttct aaagaggaaa 498781 tggtgacagt agcgaaaagc atgcagggac aatcatcgaa ataaccgcca aaggccaaac 498841 atgatttggc ctttttttcg ttagacatcg tttcccttta gcctttaatt ttagtatgat 498901 atgtaaatga tattgaataa aagctaggaa gtgtcgtaat gagcacaaaa cctttttaca 498961 gagatacgtg ggcggaaatt gacttgtccg cgataaagga aaatgtcagc aatatgaaaa 499021 aacatatcgg tgaacatgtc cacttgatgg cagttgtgaa agcaaacgcc tacgggcatg 499081 gtgatgcaga aacagcaaag gctgctcttg acgcaggtgc ttcatgcttg gccgtggcca 499141 ttttggatga agcgatttca ctgcgcaaaa agggattgaa ggcgcctata ttggtgcttg 499201 gcgcggttcc cccggagtat gtggcaatcg ctgctgagta tgacgtgacc ttaacaggtt 499261 attctgttga atggcttcag gaggcagccc gccacacgaa aaaaggttct cttcattttc 499321 atctgaaggt cgatacgggg atgaacagac ttggtgtaaa aacagaggaa gaagttcaga 499381 acgtgatggc aattcttgac cgcaaccctc gtttaaagtg caaaggggta tttacccatt 499441 ttgcgacagc ggatgaaaaa gaaagaggct atttcttaat gcagtttgag cgctttaaag 499501 agctgattgc tccgctgccg ttaaagaatc taatggtcca ctgcgcgaac agcgccgctg 499561 gactccggct gaaaaaaggc ttttttaatg cagtcagatt cggcatcggc atgtatggcc 499621 ttcgcccgtc tgctgacatg tcggacgaga taccgtttca gctgcgtccg gcatttaccc 499681 tgcattcgac actgtcacat gtcaaactga tcagaaaagg cgagagcgtc agctacggag 499741 ccgagtacac agcggaaaaa gacacatgga tcgggacggt gcctgtaggc tatgcggacg 499801 gctggctccg aaaattgaaa gggaccgaca tccttgtgaa gggaaaacgc ctgaaaattg 499861 ccggccgaat ttgcatggac caatttatgg tggagctgga tcaggaatat ccgccgggca 499921 caaaagtcac attaataggc cggcaggggg atgaatatat ttccatggat gagattgcag 499981 gaaggctcga aaccattaac tatgaggtgg cctgtacaat aagttcccgt gttccccgta 500041 tgtttttgga aaatgggagt ataatggaag taagaaatcc tttattgcag gtaaatataa 500101 gcaattaact tacctaaatg gagaattcat aaaacagctt tgcttgaaga gtgaataatg 500161 gtatcattat cactggatgg ataaaagagt cgtatccgta agtttggtgg aggtgtatgt 500221 tttttgtctg aatccagcgc aagaaccgaa atgaaaatca gcttgcccga aaacctagta 500281 gctgaattgg atggtgtagc gatgcgggag aaacgaagca gaaacgaact gatatcacaa 500341 gcagtgagag cgtatgtcag cgaacgaaca actcgtcaca accgtgattt gatgagacgc 500401 ggctatatgg aaatggcgaa aatcaacctg aatatttctt ctgaggctca ctttgcggag 500461 tgcgaggctg aaacgacagt tgagcgctta gtcagcggag gataatcatt tgattgtgaa 500521 acgcggcgat gtttattttg ctgatttatc tcctgttgtt ggctcagagc aaggcggggt 500581 gcgcccggtt ttagtgatcc aaaatgacat cggaaatcgc ttcagcccaa ctgctattgt 500641 tgcagccata acagcacaaa tacagaaagc gaaattacca acccacgtcg aaatcgatgc 500701 aaaacgctac ggttttgaaa gagattccgt tattttgctg gagcaaattc ggacgattga 500761 caagcaaagg ttaacggata agattactca tctggatgat gaaatgatgg ataaggttga 500821 tgaagcctta caaatcagtt tggcactcat tgatttttag acatatttgc aggttgctca 500881 aatagagcaa ctttttttgt tttcaaaaaa cataaacgat ataatagtga aataacgaaa 500941 aaatatgttg ttttttattg ggaggtaagc gaatttgatg tcgaaccaga ctgtatacca 501001 gttcattgcc gaaaatcaaa atgaactgct ccaactgtgg actgacacac taaaagaatt 501061 aagcgagcaa gaatcctatc agctgactga ccaagtgtat gaaaatatat ctaaagaata 501121 tatcgacatt ctgctgctgt ctgttaagga cgaaaatgct gctgaaagcc aaatcagcga 501181 actggcgctt cgagcggtcc aaatcggact gtctatgaag tttttggcta ctgcacttgc 501241 cgaattctgg aagcgtctct acacgaaaat gaatgataag agattgccag atcaagagag 501301 cacggaatta atctggcaga ttgatcgctt tttcagcccg attaacacag aaatttttaa 501361 tcaatactca atctcatggg aaaaaacagt atccctgcaa aaaatcgcgc tgcaagagct 501421 gtctgcgccg cttatcccgg tgtttgaaaa tatcactgtg atgcctcttg tcggaacaat 501481 tgataccgaa cgcgcgaaac gaattatgga aaaccttctt aatggcgtcg tcaaacaccg 501541 ttcccaagtc gtgctgattg acattacagg tgtccctgtc gtcgatacga tggttgccca 501601 tcatattatt caggcatcag aagctgtaag gcttgtcgga gcaaaatgcc tgctggccgg 501661 aatccgtccg gaaattgctc aaacaatcgt caacctgggg attgatttat cccaagttat 501721 aactaagaat accctgcaaa aaggaattca aacagcattg gaaatgacgg atcgaaaaat 501781 cgtttcattg ggggaataac attttgagac atccgaaaat cccgatcttg aaactgtata 501841 attgcttatt agtgtccatt cagtgggaac ttgatgacca gacagcatta acttttcaag 501901 aagacttatt aaataaaata tacgaaacag gtgctaacgg agtcgtcatt gacctgacat 501961 ctgtggatat gattgattca tttatcgcga aagtgctggg ggacgtcatt acaatgtcta 502021 agttaatggg ggctaaagtc gtcttgaccg gcattcagcc cgctgtggca gtgacgctga 502081 ttgaacttgg aatcgcgctt gaggaaatcg aaactgcgct cgacttagag caggggcttg 502141 agacattgaa gcgggaattg ggggaatagc gaatgaacga ccaatcctgt gtaagaatca 502201 tgacagaatg ggatattgtg gccgccagac agctgggacg aaacgttgcg aaagaactgg 502261 gtttcggcac ggtagaccag gctagaatta caacggctat ttcagaatta gccaggaata 502321 tttatttata tgccggcaaa gggcagattg gaattgaaca ggtcgcagac agaggaaaaa 502381 aaggcctgaa aatcatagcg gaagaccaag ggccgggaat tcctgatatc cgaaaagtca 502441 tggaagacgg gttttcaacg tctggaggac ttggtgcggg acttcccggg gtcaaaaggc 502501 tgatggatga attcagctta aattccgtag cgggggaagg aacagagata caagccatca 502561 aatggcttcg gtaggaggta agaacgtgga ttttagggag gttattgagc agcggtatca 502621 tcagctgctt agtcgatata tagccgaatt aacagaaaca tctttatatc aagcccaaaa 502681 attcagccga aaaacaatcg agcaccaaat tcctccggaa gaaatcatca gcattcacag 502741 aaaagtgctg aaggagctgt atccaagtct cccggaagat gtgtttcatt cgctggattt 502801 tttaatagaa gtcatgattg gctatggaat ggcttatcag gagcatcaaa cccttagagg 502861 gatacagcag gaaatcaaat cagaaattga aatcgcggca aatgtccagc agacgcttct 502921 cggaactaaa gttcctcagg aggaagcgct ggatatcggc gccatcagtg ttcccgctaa 502981 acagatgagc ggtgattact accactttgt caaagacaag gaatccatca atatcgcaat 503041 cgcggacgtg atcggaaaag gcattccagc ggctttatgc atgtccatga ttaaatacgc 503101 aatggactct ttgccggaaa cgggcataca cccttctcaa gtgctgaaaa atttgaatcg 503161 tgttgttgaa caaaacgttg atgccagtat gtttattacg atgttttatg cgaattacaa 503221 tatggacaag catcaattta catatgcttc agcgggacat gaaccgggat tctattattc 503281 tcaaaaagac aacacgtttt acgatttaga ggccaaagga ctcgttctcg gcatctcgca 503341 ggactatgac tacaaacaat tcgatcagca tctggaaaag ggcgatatga ttgttttatt 503401 ttctgacggc gtcacagaat gcagaacgga aaacggtttc ttggagcgtc ctgatctgca 503461 gaagctcatt gaggaacata tgtgttcctc tgcgcaggaa atggtcaaaa acatttatga 503521 cagcctcctc aaattgcagg attttcagct tcacgatgat tttacgttaa ttgttttgcg 503581 gagaaaggtt taacgtctgt cagacgaggg tataaagcaa ctagtgattt gaaggaaaat 503641 ttgaggtgat acgaatgaat ataaatgttg atgtgaagca aaacgagaat gatatacaag 503701 taaacattgc aggagaaatt gatgtatact cagccccggt gcttagagag aagctcgttc 503761 ctctggcaga acaaggagct gacttaagaa tttgcctgaa agatgtcagc tacatggaca 503821 gtaccggatt gggcgttttt gtagggacct ttaaaatggt gaaaaaacaa ggtggttcgc 503881 tgaaacttga aaatctttct gaacggctga tccgactgtt tgacattaca ggcttgaagg 503941 acatcattga tatttctgca aagtcagaag gtggagtgca atgaagaata atgctgatta 504001 catcgaaatg aaagtgccgg cccaacctga atatgtggga attataagac tgacgctgtc 504061 aggggtcgca agcagaatgg gctatacgta cgatgaaatt gaagacttga aaatcgcagt 504121 cagtgaggcg tgcacaaatg cggttcagca cgcttacaaa gaagataaaa atggggaagt 504181 gtcaatacga ttcggtgtgt ttgaagaccg tttagaggtt attgtggcgg atgaaggaga 504241 cagctttgac tttgatcaaa agcagcagga tctagggccg tacacacctt cgcacacagt 504301 tgatcaatta tcagaaggag ggctcggtct atatttaatg gaaacgctca tggatgaagt 504361 cagagtgcaa aaccactccg gcgtcaccgt agcgatgaca aagtatttaa atggggagcg 504421 agttgatcat gacacaacca tcaaaaacta cgaaactaac taaagatgaa gtcgatcggc 504481 tcataagcga ttaccaaaca aagcaagatg aacaagcgca ggaaacgctt gtgcgggtgt 504541 atacaaatct ggttgacatg cttgcgaaaa aatactcaaa aggcaaaagc ttccacgagg 504601 atctccgcca ggtcggcatg atcgggctgc taggcgcgat taagcgatac gatcctgttg 504661 tcggcaaatc gtttgaagct tttgcaatcc cgacaatcat cggtgaaatt aaacgtttcc 504721 tcagagataa aacatggagc gttcatgtgc cgagacgaat taaagaactc ggtccaagaa 504781 tcaaaatggc ggttgatcag ctgaccactg aaacacaaag atcgccgaaa gtcgaagaga 504841 ttgccgaatt cctcgatgtt tctgaagaag aggttcttga aacgatggaa atgggcaaaa 504901 gctatcaagc cttatccgtt gaccacagca ttgaagcgga ttcggacgga agcactgtca 504961 cgattcttga tatcgtcgga tcacaggagg acggatatga gcgggtcaac cagcaattga 505021 tgctgcaaag cgtgcttcat gtcctttcag accgtgagaa acaaatcata gaccttacgt 505081 atattcaaaa caaaagccaa aaagaaactg gggacattct cggtatatct caaatgcacg 505141 tctcgcgctt gcaacgcaaa gctgtgaaga agctcagaga ggccttgatt gaagatccct 505201 cgatggagtt aatgtaatga tccaggttga agaaaacgag catattcaaa ctctagtata 505261 tcaactgaat aaagaaggga aatcgatttg cggtgacagt ttttttatga aagctgatga 505321 taaggagtta atttgcgcgg ttgctgacgg actgggaagt ggatcacttg ctaacgaatc 505381 ctctgcagcc atcaaagact tagtggaaaa ctatgcgagt gaagacgtag aaagcattat 505441 cgaacgctgt aatcaggcga tgaaaaacaa aagaggcgct acagcatcta tcctgaaaat 505501 caattttgag caaaggcagt ttacgtactg ctctgtcgga aatgtacggt ttattctgca 505561 ttccccgtct ggtgaaagct tttatcctct gccgatttcg ggctatttat caggcaagcc 505621 gcaaaaatac aaaacgcaca ccgccaccta tgaaaagggt tcaaagttca ttatacatac 505681 agatggactc aacgtacctg atatccgctc ccatttgaaa aaaggccaat cggtagaaga 505741 aatatcgaat tcgctgaaaa tgtatacgac atcgagaaaa gatgacctga cctatattct 505801 cggacagctg tcctaaaaaa ccagaaaaag aagctggaca tccggcttct tttttttgcg 505861 gttgactatt aataagtgcg cttattatac ttaataagtg aacttatcat tctgggagct 505921 tatgggatgt ggaattatga atacacagcg atagctgatg tggatgtggg aaaacctgga 505981 actgttatca ggaaacagaa acaatggatc aatgggagac gggtattgca tcagattctt 506041 tgaaaggaca atttcaaaat ggaacggaag gaacattgct tctgcaagga aaaacaattc 506101 tcttatggct tgagcatgtg gagaaacatc gggcgttttc tgtcatggtc aacatgcccg 506161 catagcaatg taataatgga gttttttcac gtgcttcaaa agcaaaaaga agatttgtgt 506221 atcacatatg gaattgtatt agaaggcgct gaagcaaaaa agtggggaga aatcattggg 506281 actgaactgt ctaaagacat gccgacggct gtcagcaggc ttgtccatct ttacggagga 506341 gtgataaaat gaacacaaat tactggatcg gcgttgtgtc agagcaacat gtattaaaag 506401 gcgctgccgg cggttttgca cagctgtgcc atggaaaaaa agccccgctc gccaaaatga 506461 aagagggaga ttggctgatt tattattctc cgagagacgc atatccagac ggcaaactgc 506521 tgcgaagctt tactgcgatc ggcaaagtaa aaagcggaaa catctatccg tatcaaatgg 506581 ctccgaattt tattccatac cgattagata tagactatta tccatgccat aaaatcggtt 506641 tttacgacat taaatcaaag cttgaatttg ttcaggaaac caagcatctt ggctttttat 506701 ttcgcagagg acactttgaa ataagcaaaa aagatttttt gacaatagca caagcgatgg 506761 gagttaacat aagtggaatg gcactctaaa tttagcggtc cgaacacaag cccgggcttt 506821 ttattatggc aggccacgca aagttggcag cggaaagtag gaaaagcatt ggctgagttt 506881 gacctgaccc acgttcaatt tgttctgctg acctcgtgca agtatatgat tgctcacgga 506941 gaaaccgtca cgcaaaaaaa acttgcaagc ttcagccaga ccaatatcat gatggtttcg 507001 gaggttgtgc ggacgcttga gaaaaaagga tttatcgaaa gaagcaaaaa tccccaggat 507061 aaaagagagg tcctcctgtc tcttacagaa ataggaggag aaaaagtaac agcggctttg 507121 ccaattgttg agaagattga tcaagccttc tttgcagctg cgatgaaaaa agagaatttt 507181 ctgagcggct tacaggaact attgaaacat gagtaaagat acgggcagcg ccagctgtct 507241 ttttttatgt gtttttttcg gtttttgata cactagagaa agaacgacaa aattggaggc 507301 tttggttaca tggaaacgtc agccctttta aaacagcaaa ttgcgaaaga aataggttta 507361 tcacaaaaac acgttgaaag tgtcatccgc ctgcttgagg acggcaatac agtcccgttt 507421 attgcccggt atcgaaaaga gcagacgggt tcaatggatg aggttcagat tcagacgatt 507481 tctgaacgct ggcaatacat acaaaacctg aatcagcgaa aagaagaagt catcaggctg 507541 attgcagagc aggataaact gacagataat ctaaaacgta aaatcgagca atcggtgaag 507601 cttcaggaag tggaagacct ttaccgccct tataaacaaa aacgtaaaac aaaggcgaca 507661 gtcgccaaaa gcaaaggcct tgagccgctt gccgactata tcctgacact tccccaagat 507721 gatcatctgg cagcaactgc agaccaatac atcagcgaag aaaaagaagt gttcacacga 507781 gaagaagcga ttgaaggcgc caagcacatt attgcggaac aaatctcaga cgagccgacc 507841 ttcagaaagt ggattcgcca ggaaaccttc aaaagaggaa ccattaagtc tgcagccgga 507901 aagtcggcag acaccgatga gaaaaatgtg tatgaaatgt attacgagta tgaagagcca 507961 attgcaaaag ttgttccgca tagggtgctg gcaatgaacc gcggcgaaaa agaagacatt 508021 ttaaaggtag cgatcgaacc gcctgcggat cacattaagg cgtatttaga aaaacaaatc 508081 atcaaaaatc gctcaacatc cgtaagagag attttgcagg agacaattga agacagctat 508141 aaaaggctga tccagccggc aatcgagcgt gaaatcagga aagagctctc agaaaaagct 508201 gatgaacagg cgattcatat tttctcagag aacttgagaa agcttctttt gcagccgccg 508261 atgaaaggca aaaccgttct cggtgttgac ccagcctttc gaactggctg taagctcgct 508321 gtgtcagatg agaccggaaa agtcttgaaa attgatgtga tctatccgca tgcgccagtc 508381 aacaaaacaa aagaagccca tgaaaaagtg aaaaagattc ttgagcagta tcaagtcgag 508441 atggtggcga tcggaaacgg cacagcatcc agagaaacag agcaattcat cgtcaatgta 508501 ctcagagaca tgccgcgcaa aatttattat gtgatcgtca atgaagcggg agcaagcgtc 508561 tattcggctt cagagcttgc cagagaagaa ttccctgacc ttaaggttga agagcgcagt 508621 gccgtatcta ttgctcggag acttcaagac ccgctcgcgg agctcgttaa gatcgatccg 508681 aagtctgttg gtgtcggaca gtatcagcat gacgtcagcc aaaaacgctt aaatgaatct 508741 ctgcggtttg tcgtcgaaac tgtcgtaaac caggttggag taaacgtcaa cacagcctcc 508801 gccgcgctgc ttcaatatgt agctggatta tcgaagtctg tagcaggcaa cgttgtcaaa 508861 aaacgtgagg aaatcggaaa gttttcaaat cgaaaagaac tgaaggacat cccaaggtta 508921 ggtgcgaaaa cctatgagca atgtatcggt ttcttaagag tgcaggaagg gacagagcct 508981 ttggatagaa caggcatcca cccggaaagc tataaagaaa caaaagcact tttgaaaaaa 509041 ctcggacttt caacagaaca tatcggcacg gcggaattga aggacaaaat caatcagctg 509101 gcgctctctg aaacggcaaa agagctggga atcggcgaaa tcactctgaa agacatttgt 509161 gaacagctga caaggccgga acgcgatcca cgcgataagg tgcctaagcc tttgctgaaa 509221 acagacgtcc ttcagctgga agatttgaaa gagggaatgg aactgcaggg caccgtgcgc 509281 aatgtagtgg acttcggagc gtttgttgat atcggagtca aacaagacgg gcttgtgcat 509341 atctcaaaat tgagcaatca attcgtcaag catcctcttg atgtcgtatc tgtcggcgat 509401 attgtgacag tttgggttga cggcgtagat gtacaaaaag gcagagtatc gctgtctatg 509461 gtaaaataaa agcactgctt acgagcagtg ttttttccta tagaaatacc agcattgatt 509521 cagcagttta atttggtaat tatctttttc aaggaacgct ttttgcatct gctttttaag 509581 ccaatttggc ataggctcat tcctcctcag cttttatcat aagagggaca gtgattacca 509641 tattgtatgc gaacggtgaa ttgtcccgtt caatgttttt taagtgaggt gcaccatgga 509701 taacaaagag cttcaaaagc tgacagagga tatttctgaa acatatttta aaaagccgtt 509761 ccgccatcag gcgcttttta atgaccggct taaaaccact ggcggcaggt acctgttaac 509821 ctcccataac attgaattga acagaaaata tttgattgaa cacggcaggg aggaactgat 509881 tggcatcatc aagcacgagc tctgccatta tcatcttcat cttgaaggaa aagggtacaa 509941 gcacagagac agagatttta gaatgctatt gcagcaggtc aacgcgccga ggttctgtac 510001 accccttaag aaaaaagcgg aaaacaaaaa aacttatatg tatatctgta cgacctgcgg 510061 ccaacagtat ataaagaagc gcgccatgaa ccctgacaga tacagatgcg gaaaatgccg 510121 cggaaaaata aaaagaattt tttcgtgaaa aaggttgacg aatatggcaa gcctatgtta 510181 cattataaaa gtcgtcacga gagataaata aaaacattta cctcttgaca ctgcaaatca 510241 aggctgatat aataagtctt gtctcattat tccacagtag ctcagtggta gagctatcgg 510301 ctgttaaccg atcggtcgca ggttcgaatc ctgcctgtgg agccatattg gagaagtact 510361 caagtggctg aagaggcgcc cctgctaagg gtgtaggtcg cgtaagcggc gcgagggttc 510421 aaatccctcc ttctccgcca taagatttcg atataagttc tcaaccatcg gcccgttggt 510481 caagcggtta agacaccgcc ctttcacggc ggtaacacgg gttcgaatcc cgtacgggtc 510541 attccatttc gttgggctat agccaagcgg taaggcaacg gactttgact ccgtcatgcg 510601 ttggttcgaa tccagctagc ccagccattt ttatttttga aatctaatag taagagccat 510661 tagctcagtt ggtagagcat ctgactttta atcagagggt cgaaggttcg agtccttcat 510721 ggctcaccat ttgtcttttt gcgggtgtgg cggaattggc agacgcgcta gacttaggat 510781 ctagtgtctt acgacgtggg ggttcgagtc ccttcacccg cactttattt acaaagtgca 510841 cgcaaatctg ttttactagg ttaagagcct actaaaccag cacaacacaa tttaatgatc 510901 acgcggtcgt ggcggaatgg cagacgcgct aggttgaggg cctagtgggt gaataacccg 510961 tggaggttca agtcctctcg gccgcatctc aataatacca agggtttaac cacctttggt 511021 attatttttt tgtgtggaaa atacggctat gggagaagac ttgctcacca aaactcacca 511081 gttacttaaa gtaagtcatc caaacggtcg gcggttcctt ctgtttatta ggaaaaagat 511141 atccgttcat tgtaaaagaa acgaaccatg tcctattcgt tcaaaaaaac taaagggtga 511201 tacatattat acatgattaa tatgtatcac ccttttcttt cttgttcaac aatcgcgctt 511261 gaggagaaca taagctaata caactgactc gatttctaaa gttgctccat tcttttttta 511321 aacaactcat ccacaacctg ttttaaaatc tcgtacgact gaatttcctt gctcaattcg 511381 taaatattag ataacacaat taattcatct gcgtgataca tttgttggaa atcaattagt 511441 tcgcgacgaa ttgtttctcg atcacccatg attgtatacc ccagtcgact gtggagaatt 511501 tctaattcaa actgtgataa cgattctagg aagttttcag tgggtggaat aagcttactt 511561 aaattatttg tataaatatc aatatacacc tgcaaatgac ttgcagaaat aaaagatgcc 511621 tcgtctatag attctgctgc aatcacatta atgcaagcga tcacataagg ttcttgtaaa 511681 taagaagacg gttggaaatt ttctcgataa atagagagcg cttcttccat cgaatggggt 511741 gaaaattgag cgccaaatgc atagggtaaa ccaagctttg cagcaatttc cgctgaatcc 511801 gttgaggatc ctaacacaaa aacaggcaca tgcgttccaa tacccggata agcgcgaacc 511861 tcaccctgta cactcttatc cccgacaaaa cgcaaaatat catttacttc tctttcaaag 511921 aaaaacactc cattatggtt ggaacgacga atcacatcgg ccgttttttg atccgttccg 511981 ggtgcgcgtc ctaatgccaa atctacacga tttggatata atgtttcaag tgttccaaat 512041 tgctccgcta cgattaatgg ggaatgattt ggcaacataa taccccctga acctacgcga 512101 atgtcttttg tatttgctaa tatatgttgt acaattgata cggttgctgc acttgcataa 512161 gcgtcgtgat tatgatgctc tgcaaaccaa atccgtttat agcccatatt atctacagct 512221 ttagctaatg acactgcaga atcaatccct tgtttcattg tttctccttg tcttaatgga 512281 gcaactgata aaacagatat atcaaatttt ttcataattt cacctctaaa ataatgaact 512341 tatacaagat caatggaaaa aacattttga aaaattgttt catattaaat ggtgtccatt 512401 cctctttgat ttgcatgcaa ataaatatat actttctcaa acgatcaata cataggcaaa 512461 ataaagttat ttcacaattt cactttactt ttaaagtttt aagcaaacat aaaaaaatgt 512521 tcagtgaaca aaatatgtaa aatacatctt atttttcaga aaggatacaa gaaaatgatt 512581 gatgaaatag ataaaaaaat acttgatgag ctgtctaaaa atagtcgcct tacaatgaaa 512641 aaattagggg aaaaagtaca tctcactgca ccagcaaccg catcaagagt agtaaagtta 512701 atagacaatg gcataataaa aggatgtagt atcgaagtga atcaagtgaa attaggcttc 512761 tctatacatg cttttcttaa tatttatatc gaaaaaatcc atcatcaacc ctatttagct 512821 tttatagaaa cacaagataa ctatgtaata aacaattata aagttagtgg agacggttgc 512881 tatttgcttg aatgtaaatt tccttcaaac gaggtattag atcaattttt aaatgactta 512941 aataaacatg caaactataa agtgtcgatt gttattggta aatagttaac tttataaaac 513001 ggagatgtgc ggtcatataa catgatatat atgctctaaa aaagccctag gttggatatg 513061 gaatttacca agctggggcc tttttataca ttataataac aagcgcatta ttcatcagac 513121 attaatgaag tattataatg cttttttact tccttaatag acaaataaag ctgatagttt 513181 ccatacttca ataaatcatt cagaaggtga tttaaaactt cttgtgaatg aaccgttacc 513241 ttcagaagat aacatgcatc tcccgaaaca cgatgagctt cgctaatttc attacgagta 513301 gcaataaatt tcaataaatc atcatgcata tatgcattca tgaaaaagaa gacaaaggct 513361 gtaaaagaaa accccatctt caattcatca accacaatcg aatatgcttt aatgataccg 513421 ttatcctcca tttttttgat gcgattgcct accgcttgtc ctgtcatatg aattttttca 513481 ccgatttctt tccattgtat ccgagcattt ttatttaata attggagaat ttgaaaatca 513541 attgaatcaa tttgcatagt aactcctttc acagtgaaaa agttttacaa aatagtattt 513601 catgagacca tcgaaaattc aatggaaatt atatatcctt atacagtata aaaattttaa 513661 gaggtgaaaa aatgacaaca gctttattag tgattgatat tcaaaatgat tactttccaa 513721 atgggaagat ggctttaaca aacccagaga aagcagcaca aaatgcggct aaactacttt 513781 cacactttag aaacacaggc gcacctgtct ttcatgtaca gcatatcaca gaaggtaaca 513841 tcgctcattt tttccatcca aatacagaag gtgtcgaaat tcatgagtca gtacgtccat 513901 tagagaaaga gacagtcatt gtaaaacata tgccgaatag ctttttcaat acagatttaa 513961 atggaaagct acaagaagaa ggggttaaag aattagttgt ttgcggtatg atgtcccata 514021 tgtgtattga tgcaacagtt cgttctgcag ttgaacatgg ttatgtatgc caagtggtag 514081 aagatgcttg cgcaacaaca acattgcaaa ttgaagataa aatcgttcct gctgagcatg 514141 tccattacgc atttatggcc gcattaaatg gtgtctatgc aacagtaaaa accacagagg 514201 catttttaaa ataaaagaat ttcctgcgcg aacataacgt ctttcttttc acaagaaaga 514261 tgattcaaca acttaaaaaa ggatgttcag aaaaatactt ctggacatcc tttattcatt 514321 atcttttatt gtttttcagt atcattattc ccatctgata aaagatcaag atgtcctgtt 514381 tttgatccat agtaagacca tatacaggga ttgtttttgc cataaatata gatattgatg 514441 aaggtttaca taaagcacct aattgcttga tttactttaa tgttagatcc ctcaataact 514501 ccattctctt ctaatttctc tactctagct gtagctgctg ggcatgttaa atgtactctc 514561 tcccagatct ttcattgaat tcggctatta tacataattt ctctataatt ttttatctgt 514621 ttgatctatt tgaacgttaa ttcctttcga aaataaagtc aaagagttaa aacacttttt 514681 tttatctatg tattcgaaca ctgctgatat tatacactta actctgtcga tctaagacaa 514741 ataaaaaaag aaagtgagtt gtaaatatga atattacaca aattcgaaat gcaacaattg 514801 ttgtaaaata cgcaaataaa aaatttttga tagatcctat gttagcagag aaaggtacgt 514861 acgctacttt ccctgaaacg atcagacaag atttatttaa tcctttggtg agtttgccaa 514921 catcaattga taacattctg gatggcgtag atgcggtaat tgttactcat ctacacctag 514981 atcactttga tgatgtggca aaaaacgtat tgccaaaaaa catcaaaatg tttgttcaaa 515041 atgaagcaga tgcaaaagaa gtaaaagcaa gtggtttcaa aaatgtagaa gtgctacatc 515101 aagacactgt ttttgaaggg atccaattag taaaaacaaa aggtgaacat ggcagagggg 515161 aagagttatt aaacttaatg ggtgatgttt gtggattagt attcaagcac ccaagtgaaa 515221 aagttttata tgtagctggg gatacagttt ggtatgatgc tatcgaagac gagattcata 515281 cacatcaacc agaaatcatt gtggttaatg gtggagacaa tcaaagatta gatttaggtt 515341 cactcatcat gggaaaagaa gacatctatg aagttcacaa ggctgctcct catgctaaga 515401 ttatatctgt tcatatggaa gctgttaacc attggacact atctagagaa gaattaaaaa 515461 actttagtaa agaaaaagga ttctcaagta atattttagt gccagaagat ggcgagtctt 515521 acacatttta atatgaacac cgacaaataa atagaagaag ctcataatta taaaaactaa 515581 tcatgagctt cttctaataa tgaatatttt aaattttaaa tatatcgaaa atcctaaata 515641 tacggaataa caaaaatgga atgttccaat gatgacaaaa aaacttgaaa agcaacaaag 515701 atgtgtcgtt aggaggtaga attcatggta atgacaaaaa aagatacaaa tatatcaaca 515761 cagcagcctc tttggttaca aggttatatt gattcaccag aaaaacaaaa ccaactttat 515821 aaaaaaacat taaaaatctt gattttttca caaatatttg ggggagcagg acttggagct 515881 gggataacag ttggggcgct tcttgcacaa gatatgatag gatcggaaaa tgtagcagga 515941 attccaactg ccctctttac ttttggatct gccgtagctg ccctgcttat aggagcatcc 516001 tcacaacgtt ttggtcgcag agctggactt gcaggtggtt tccttatagg cggattaggt 516061 gctataggtg tgataatcgc ggctttaatt aacagcgttg ccctattatt tgtttctctt 516121 cttatttatg gagcaggtat ggcttctaat cttcaagttc ggtatgctgg gacagacctt 516181 gcaaatgaga aacaacgggc aactgctgca agtatggcct tagtttctac tactttagga 516241 gctgtagtag gtcctaactt agttaataca atgggggaat ttgcagattc aattggtgtt 516301 cccaatttag ctggtccgtt tattatgtca ggagcagctt ttataattgc tggaattatt 516361 ctcttaattt ttcttcgtcc agatccgctg tttgtatcaa cagctattgc gaatgctgag 516421 aaaaaagacg ataaagtaca aataggagga agtctaaaaa atcctgctat agacaaaaaa 516481 ggaataatgg taggagctgt cattatgatt ttagctcaac taatcatgac agctattatg 516541 acaatgacac cggttcacat gggtcatcac ggtcatggtt taagcgaagt gggattagtt 516601 ataggactcc atattgcagc gatgtatctt ccttcaccat tgactggttt attagtagat 516661 aagtttggtc gcacaactat ggctattgct tcaggtgcca cacttcttgc cgctgggttg 516721 gtggcagcta ttgcaccggc agactcatta tcattgctaa tcctagcact agtattacta 516781 ggggtaggtt ggaactttgg tttactaacg ggaactgccc ttattataga ttcaacacat 516841 ccatctctac gtgcaaaaac acagggaaca ttcgatgttt tattagcact atcaggagca 516901 gcaggtggag ccttgtcagg aatggttgtt gcacattcta gttatacaat actatcaatt 516961 tctggagccg ttttatcatt gttactcatt ccagtagtta tttggtattt tagaaggatt 517021 caggaaaaag cataagctta tataactgtc tttgaagaac ctaagtagac attactttac 517081 cggaacctcc tttttctatt tattatagta aggagttgac atggcattag tggcatgtgt 517141 ataactacac aattatttgg gattcagaga gcatgtaatg aacggaagag ataattattt 517201 atcactttta ttattgtacg gtgttcttgt ggcattaagt tcagtcaatt ttggtctaac 517261 tgttttcttt ttgttttcat cacctctcca tattattaac aaacacgaaa aggattttaa 517321 tgaaaataaa atgattagcg tatgtatctc taattttcaa aatgaatgaa tagtcctttt 517381 taagatttac acacttattc tccaaggaaa aatgactcaa tttttcgatt ttttatgtaa 517441 atcaaaaaag aatcatgtta gagtaggtgt gctgaaaata attcaaaaaa ttattttgcg 517501 atatgattaa agtaatattg ccagagagtt tcaattggac aaaattgtaa gtgtttaata 517561 cactggggct gcaatcaaat atgcacctgg aatcaattgc taaacggggg agtttatatg 517621 aacaacaaga aaaatatctt tgatattgtt atgtacatta ttttcggtgt gttaagtctt 517681 tttctagttg caaaaactga ttatggcact ggagttttag tgtttgttgc aattttatac 517741 ctcgctgtta ttgcttataa aattaagcaa gtatttagta attcagattc ttaaggtgta 517801 acacaaggag gatttcaatt gagaaagaaa agagttatta cttgtgttat ggctgcatca 517861 ttgactttag gctcactttt acctgcaggt tacgcttctg caaaggagga ctctaagaca 517921 accccttctt acgaagaact agctctacat tacaaaatga aaagtgaaaa gatttcatcg 517981 aacgggaaat tagttgaaat tgagtatgtg agtggaaatg aaactcacaa agttcagatg 518041 aacggaaata atcatactgt aaaagtcgat ggcatagaac aaaaaggttt aaactttgag 518101 tatgatgaaa atgttgctaa aagaacaaat tatgaaaaca ataatttgaa atcaaatgaa 518161 ttcacaacac aggctgcaaa acctaaaaag ggataccatt atgtggggac tttatctggg 518221 catacaaaag cagctaaaaa tgcgttatca gttacaatgt cattagtcgg tattgtccct 518281 ggcttgggat gggggagtaa ggctgccact attttattct cttattgggc aaaagaacaa 518341 atccctgatg cgtattataa atatgattta tacgaaaaag gagcaatgac tgatagttgg 518401 tatcagtatg ctacagttca attttttgaa gataaagctc ataaaaagaa aatgggcaaa 518461 ccttggacaa gtactcctgc aaaagtagat ttacctaata gctaatttta aaatcacttt 518521 gtctttataa aggacaaagt gattttttgt tatacagaag taaaatccct cgtctgagga 518581 atcttggaaa aaacttggtt caattttgat ataacatgtt tttttcttgc taatttagtt 518641 tttctatgta tcgctacaca ttctaaataa taagatatta gccggacggt tgatgccaag 518701 ctcaaaagtt tatatggaag tcaaagcata aaaaagggtg ttacaacgtg tagtcttctt 518761 tttattttgc caacgtaaca agtgtgaaag taatgatttg taggatcagt taagaaaggt 518821 ttaagattag atattgaaaa attttatata ttttcaataa aatactggta ctataataaa 518881 tgtatacaga ttgtatggag atgtaattaa ttaaaaagga gttttttaat tgcgttggag 518941 taaatggttc aatgtttttt gtatagtagc attgggatca atatatggtt ataaattatt 519001 tactaaccaa gaagtcagta ctactcgttt aataatagct tctgtaattg tgttgtggaa 519061 tattgttgga ctttttagca aagaatcagt aaaacaagca cagcaagcaa attaaaagtc 519121 ataaagttgg gaaagaagga tgttacttat gtagtatcct tctttattat tccttgaaaa 519181 atgaaacaaa ttggagatta cagcttatat aatcaattga agtcgttgat tattttcatg 519241 aacaggagat ttaatgcttt ctgatgaaat attatcgtat gaatgttgca agaggaaacg 519301 ttactcaaag attacaggga tgtgatgaac actcctcttt atcgcactca cctgacccca 519361 aattgttggg gaagggcagg tacggaagat agagtatttt ttcttcgtaa caaatcgaaa 519421 aggttggata ataaaaaact tataatctaa ggcggtatat agttgtgaaa aaggcgttat 519481 ttcttatatt agaccagtat gcagattggg aaggtgttta cttagcatct gcattaaatc 519541 aaagagaaga ttggtcggtt cacactgttt ctttagaccc tattgtaagc tcaataggtg 519601 gttttaaaac atctgtcgat tacataatag ggttagaacc tgcaaatttt aatttgctag 519661 ttatgattgg cggggattcc tggagtaatg acaataaaaa actattacat tttgtaaaaa 519721 ctgcatttca aaaaaacatt ccaatagcag cgatatgcgg tgcagtggat tttttggcga 519781 agaatggttt gctgaataat catagccata caggtaattt tgtttactta tggaaagatt 519841 acaaacaata taaaccgatt agcagttttg tagagaaaca agcagtaaga gataaaaatt 519901 tggttactgc taatggaact gcccctattg aatttactaa tttaatttta gagatgattg 519961 attttgatac tcctgagaac atagagaaaa tgatgtatat gaatcgttat ggtttttatc 520021 atttttgtga taaatatgga aatccatttg ttgattaatt tgctggaaat gattttcccg 520081 aatagggggc tttgcgattg agttgaattt cctaataaag caaagaaaga tgatttgagg 520141 tcaagtttaa caaataatgc catcaatatt aatttgcagt tatttccgat tcctgatata 520201 ataaagaaga attatttttg ttcggtgtaa aggatagtat gaagattgac ttttcgtctt 520261 gatgatactt tgggcaagga tagtatatac tgtgtggtta cacactagga ggcaacaaaa 520321 atggaacaag gtacagttaa atggtttaat gcagaaaaag gttttggctt tatcgaacgc 520381 gaaaatggag acgatgtatt cgtacacttt tctgcaatcc aaagtgacgg attcaaatct 520441 ttagacgaag gtcaaaaagt atcgtttgac gttgagcaag gtgctcgtgg agctcaagct 520501 gctaacgttc aaaaagctta atcttcaatc gtttatacaa acaggctctt tatatagggc 520561 ctgttttttt atgtctatat catactcaat aaaaaaccct actcaacgtt cgagtaggga 520621 gatgctacaa ggtaatagaa aaagatttaa aacttcaaag gtttgtttac agtataacat 520681 actggattga caatatgcgg aatgtatata aattatttaa tgttttgttc aaatatagat 520741 aactgactct ttttttcact aacctgttcg ttcatttaag taagattaga tgaattataa 520801 aaatggtttc atctaaatgt tatcaactcg catatctctt ttatgagaag aagataaaca 520861 attattattc aatgttgcag tggatataag aaattcttaa aaataatgag gagatcgatt 520921 gtttttttct cctggaaata atcacttaga gatacctaaa acaatgaaag ccctacctct 520981 cttccatcct tacggctcct tgtccgtgcc agtgtgaatc aggatactaa aaaaagtgac 521041 tattttattg agttttttgg taaaacttca atcttcgcag aagaaatgta aataataaaa 521101 atggattaga atgtaggaat aacaaaagag gtcgttaatg ttctaaacat aagttggaga 521161 agatttgctt ttcatcataa tattccgaaa tatcttttgg gatgtatcta accaaaactt 521221 tttatttgtt tttcagtgat tcctttaatt acttccagtt cactaatcaa aaattcatat 521281 gcattatcca gcattttttt ttcgcttgca ttaagtgctt tttctttctt catacgcatt 521341 aaatcacgta caacttcagc accttcttgt atttcacctg tttttatttt gtccgtgttt 521401 attttgtacc tttgcttcca tggcagtaac ctatcggatt ctccatgctg aaaaatgtgc 521461 ataatgtgtt ttaatgcaag tatatcggta actggtcgta tattcgaact caatatttta 521521 ctcgttggaa tcataactgt catattactg attgacattc ttatgacata atactgttgt 521581 ttttcctcta agaattcttt ttcttctatg gcttcaatta tacctgctcc gtgcattgga 521641 taaacaatgt tatcgccaat ttgaaacata tcatccacct ccatatatgg tatccttctt 521701 aagattacca tatatggagg tgtaatatca aaattttaat aataacatga tcgaattttt 521761 gatgtcaata acttttttga aaaaacagat caagcaaaaa caatagggaa cgtgtcggat 521821 ttccaatcag gaaaaggtca attgatccgt gtgagcagtt tttcattggc tcaatgacat 521881 tacagaaatg atttgagtag ataagaaaga acgatattcg tgaaatgtca gctaaaaata 521941 tttaaagcac atgattaagt tctaatttct ttaccgattt gatatggata acggccgact 522001 tacttaatga tgcattttca cttatcttgc aagcagaaaa aggtttgttg ataaacattt 522061 agccaccaaa ttggcattat tatcagggaa attgacaacc ttcaaatggg tattgaggcg 522121 agaagaaaaa taaagaaagg agagattata aatgaagacc agaacataaa gaagtaaagg 522181 ggaaagaaca aggttaattg aaaagcaaac tatataaaat agtttgcttt tttttgttat 522241 gacttcactt ctttttcttt ctctttaatg actaataaaa caccgctcag aattaaaaac 522301 gaacctatcc aaaatgtccc gcctatttgt tctccaagca gaatccatcc gagtaaggtt 522361 ccaaccagag gctgaaaaaa gaaaaagagg cctccacttg aggcatttaa taattgtaag 522421 ccgtggttcc acaataaaaa tgcacaagct gttgaaacaa ttcccaaata caaaaggcca 522481 cctagaattt tagggtcaag cagtagtggc gtaaaaatcg tgctagggga gtaccattaa 522541 cagggactcc atttattaat agaataaact ttatgaattc atttttttgt atgataatgg 522601 cgtcatattc atcgcttgtt gaaatttact tatgaaataa ctggtactgt taaatccaac 522661 ttgataagac acttctgtca cattggattc agggtgttgc agtaataata agcttttttg 522721 aattctataa tccattacat aacgtaatgg cgtcttattc agcattcgtt taaaataacg 522781 gcagcattca gaacggctca gttggccagc ttttgcaatg tcctctaatg tgattttttc 522841 aacataatgg agatggatcc agtttaacat ttgtttcatt cgatgacttt ttatcatttc 522901 agattgatcg tactctaatt gaaaaccatt aacgaccagg tttttccaca ttaacgttaa 522961 ttgcatcgta atgtcaatct catagagcga tgtcttttgt tgaatcaatt gatttatttt 523021 tttaacagca tctagaatat tttttgccca ctgttgattt ccagccaaaa ataaataggg 523081 caaattggtt gaaaacatat agggctgaac atagcttgaa tacagttcct gagataaaac 523141 gaaatggggt gacacattca agcaaatata cgtacaatcc gagccttcct tttcttcggc 523201 catgtgcagg tagccgctat tgataaataa tccatcccct tcgtgaacct ctattttttc 523261 ttcatttatt tgaaagagag ctatcccttt tagtatcaaa acaaattgga tttcatcatg 523321 ccaatgaagc ggaatatagc catttatatt ttgattgatc gttgtcttgt agcaggcaac 523381 tggcaattct accgttcggt gctctgttaa ttcttttaaa ttttgatcga tcacaaaatt 523441 cttcattctg acttcacacc tcaatatatt tatatttttt cattcaattt gagtattttt 523501 tatcatgttt tgcatttatt ataacactat tattatattt attagtgagg agtcatgtat 523561 gaatacttcc aatagaagaa tgggattgtt ctatgttatc acaggggcga catgttgggg 523621 gattggaggc acagtagcca aaaaactttt tcaagaatat caaattgatg tcaattggct 523681 tgtaacgaca cgcttgctta cggctggaat gttactttta atgctgcaac tgttcagaaa 523741 ggatcgttcc caggttattg aggtgtggaa acacaaagcg tcggctggcc agcttctaat 523801 ttttggccta ttgggaatgc tagctgtgca gtacacatat atggcatcca ttcaacatgg 523861 gaatgctgcc gttgctacgt tattgcaata tttatcccca gtaatcgtca ttatctacac 523921 gctgttgcga aaacaaacgg ttcttaccaa acaagatatc ataactgttg tacttgcttt 523981 agtgggttgc ttttttttgt taacaaatgg ttcaatgtct caactttcag tgccggcagc 524041 tgcagtagta tggggagttt tatcaggatt cgcggcagct ttttatactt tgtatgccgt 524101 tggtttatta aataaatttg attctcttgt cgttgtaggt tgggctatga ttattggcgg 524161 ttttgcattg ggttttatcc atccgccatg gcaactggat tttcaacgat taactgctga 524221 ggcgtatgca tatatcttat tcgtgatatt atttggaaca atgattgcgt tctggttctt 524281 cataaaaagc ttggaaagcc tctctccaaa agaaacaagc ctactaggca gtctagagcc 524341 tctatcagct gttgtaacaa ctgtcgtttg gttaaaagcg ccatttggtt cttttcaatg 524401 gattggtgct atttgtatta tagggataac tttaatattg gctttacata aagagccttc 524461 tatggagagt gaaaaatcga tattaaagat taggaatcat gcaaatcggg atatataggg 524521 gctttttttg cttacatgac cggtccggca atgaaaaaca ctggtggagt ttgagccctc 524581 tcggcagtat caaaaatacc aagggttttg acgccctagg tattttttct tcaagaacct 524641 tcaatttttc ttctctgatt gaaaaacgta ttactttttt gtgattggta tccaaatttc 524701 acttttaaaa gatggtgatg ttacatcctt atgctcgttc cacaatattt ctggaccttc 524761 tatttgttcg taatttgacg atggaaacca ttcggaataa atgcgtcccc atacttcttg 524821 cagtgtatcc ggaaatggcc cgattgattc gaatacagcc catgttgagg caggaacttc 524881 aagccgtgag aagttatctg gacaccgttt cgttgtggct gcgccaatat agtgatcgag 524941 ctctccgttt tcctctgtcc gaccttcaga aaaattcgtg gatgcactaa tgaggcctga 525001 tggtgctaca ttagatagct cttttagttt atttattgct ttttcatcta aactttccca 525061 catagatgca atttccggat taattccttt gaaaataata ggaactcttt ttttaatgcc 525121 aacgatgcga aatgcctctt tttcttcaat acggtagttc atttcatttc ctcctttaat 525181 tgttagctgg aaggtcattc gtggataagc tttaagggaa tggccattaa atctggcttt 525241 tgatgggttt atgccatgta aattttggaa tgcccgtgca aaagaatctg gtgagttata 525301 accgtacttt attgcaatat caatcacttt tacattgctg tctttcagtt caaaagctgc 525361 aagagtaaga cgtctgcgac gaatatattc cgataatgaa atacctgcaa ggaaggaaaa 525421 catcctttta aaatgatatt cagagcagaa agcaagcttt gctgcctctt gaaaatcaat 525481 atcattagtg aggttttctt caatatactt taacgcccta ttcatacttt taagcaaatc 525541 catttatttg gcctccttta accaaagaat aacaggagtg aaatgtattt atccgacatt 525601 ctgtgcacag ttttgcagga tgacttatat gaaataaagt aagtgattca cttgtatttg 525661 tacaggtttt attgaagcat gctgttcata aaaaggcatc aataaaagaa agttataatt 525721 gtcttataaa cggcacattc atataattga gtgaaaaagg atgcgtatca tgcctatcaa 525781 ttcttttgaa aattatccga tgagctggaa gccatcgatt gataaagctg aaaagcctat 525841 ttataaagca cttgcagggc aattggaaca ggatatttta aacggagttt tattacctgg 525901 aacaaaactt cctccacagc gagaattggc cgattatcta gatttaaatg tgagtacgat 525961 ttcaaaagca tttaaagtgt gtgagttaaa agggctgctg agtgcgactg tagggagcgg 526021 cacatttgta tcgtatgatg cgttgtcgaa tgcgtattta cttgaggata ctaagccgac 526081 acatttaatt gaaatgggag caatacttcc agatcacgct tcatatgagc ccttgttata 526141 ccaactgaaa aacatggttc atgaggagga ttatgaaaaa tggtttagct atggccgggc 526201 aggtgaaagc ctttggcaaa aagatgcagc tgtaaagctc atccaaagag gcggatttga 526261 aacatccgtt gatcacattt tatttgcaaa tggagggcaa aatgcgattg cagcgacatt 526321 ggcgagtctt tgtaagcctg gagatcgcat cggagttgac catcatacgt accctggatt 526381 aaaaactgtt gcatcattgc ttagtgtgca aatcgtaccg ataaaatcag aaaacgatga 526441 aatgagtccg gagtcacttg aatatgcgtg taaaaacgaa aatattaaag gtttgtattt 526501 aatcccggat tatcataatc cgacgacttc ctttatgtct gttgagaatc gaagaatggt 526561 tgcagacatt gtaaagaaat ataatctgtt tgttattgag gatgcatcgt accatcttct 526621 caacaaaaat ccgcttccgg cactcgcctc attcgcaccg caacaggtta ttcatattgc 526681 aagtttatca aaatcgttag cgccaggcct gcgtttggct tatgtagcag tgccgagaca 526741 atataaggag ccaatatcaa aggcgcttta taatttaaat ataactgttt ccccgctatt 526801 agctgaactt actgctcgca cgattgtatc aaatcaattt gaagtcttaa ttgagagtca 526861 tcgtgaacaa accattcgca gaaatcaact cgtaaaccga tatgttgcgg gatatacatg 526921 tttaggtgtt gaaacaggca tttttcgttg gttgttgtta ccgggtaaaa tgtctggtgc 526981 cgaatttgaa gaattggctg ctcgacttgg cgtgcaagtg tatgcggctg aacgctttgt 527041 agtgggaaat agttgtcctg aaagggctgt aagggtttct gtctgtgcac caaaaacact 527101 tgaagagctt gaacaaggat taatgatcct gagacgtttg ctagacgatc ttacctaata 527161 ttgtttgcca tacaattatg acattgtatg gcttttttgt gcgtgttatg atgatccaca 527221 tctagaggga ggtttataca aaattggctt ttagaaagga aggtcagatg atgttagaca 527281 aggacagcgt aaaagcaata gatgttcaaa ctgcttcatt acagagctac atcagttcac 527341 cagaaaaaca aaaatcgtta tacaagcgta cactattcgt tgtgagtatc tcacaaattt 527401 ttggcggtgc ggggctggcg gcaggagtga ctgtcggtgc gcttattgca cagcaaatgc 527461 ttggcactga tgcgtttgct ggtttgcctt ctgctttatt tactttaggg tcagcaggat 527521 ctgcattaat tgttggaaga ctttctcaac gttatggccg tcgaacaggt ctttcagctg 527581 gctttatgat tggcggactt ggagcaatag gcgttattat ggcagcaatc ataaatagta 527641 ttttcttgtt atttatttcg ttgcttattt acggtgcagg tacagccact aatttacagg 527701 cccgttatgc aggtacagac ttagcaaatc ataagcagcg agcgactgct gttagtataa 527761 ccatggtttt tactacattt ggcgcagtgg caggtccaag cttagtgaat gtgatggggg 527821 atttcgctct ttctattggt gttccatcac ttgctggccc tttcatttta gccgcagcag 527881 catatatgtt agcaggtgtg gtccttttca ttatgcttcg tccagatcca ttagttatag 527941 caagaacaat agaagcggca aatgaagagc ctggtgataa aggacatttg gcggcaactg 528001 agcatacaga aaacaaaaaa gggataatcg ttggggcaac ggttatggtt cttacccaaa 528061 tagtaatggt agctattatg acaatgacac cggttcatat gagacatcat gggcatgact 528121 tgggtgcagt cggtcttgtt attggttttc atataggtgc tatgtatctc ccttcacttg 528181 ttacaggtgt tcttgtagat aggttgggac gtaccgcaat ggctatttcc tctggaacaa 528241 cgttgctttt ggcaggtgta atagcagcat ttgctccggg agaatctatg attcttctcg 528301 tcattgctct ttctttactg ggattagggt ggaattttgg tttgataagc gggactgccc 528361 ttattgtaga ttcaactgat actgccacac gagctaaaac gcaggggaca gtggatgttc 528421 tgattgcgtt gtcaggagct gctggcggag cattatctgg aatgattgtg gcaggttcaa 528481 gttacctcgc attatcactt attggaggga ttttgtcctt attactcatt ccggtggtgg 528541 tatggtctag gggccgctaa agggtaggat tgtttaattt acattaattt gttatattgt 528601 tagataaagt atattgcagc atctaatatt ctaacgaact atagttgctc cattaaatct 528661 attataaaga tttgaccagg attccttata gctgtgtcac tcactgcata ttctttaatt 528721 gaatcacata aaatggttat cggatttgaa aaaggcagga ttactcgctt taggtaaagg 528781 agtcataacg ttgttaaaaa ggttttctct tgttattgtt acactaatga tgtctatcgt 528841 tgttgtttta gcggctgcta aagagtcgcc tggagatcat gtcatctcat ttgatgaacc 528901 tattatcttg atgatctcaa ttggaatcgt tgtattttta ttgatccctc cattagtcat 528961 gtcctttttt ggcaatttgg ttgtaagaat aatatctggt gtataccaat gttttatcgt 529021 tttcactttt ctggggctca ttccaattgg atttcttatt cccaatggct ttttgacaat 529081 tctagtttct attgcaggaa ctttagtcag tatagctagt gttgccgtaa ccttatgcat 529141 tggcaagaat aaaaaagata tataatcatc gaattgttat tttttcagat tgtcagtgaa 529201 ataattatac aaaaagagaa ggcttgtggg ccttcttttt ttgttgttgc atcatcccca 529261 ctttgagctt aatctattga ataataagag aaggaaccta tagaagaata aaataaatac 529321 cgagatgtca aaaataaaac tggacttcat tattgtgaat tcacgtaaat gtaaaaagat 529381 tggaaagagg ggaattcctt catgacaaat agcagaacaa atccgaaggt tgatgaattt 529441 ttaagtaaag cgaaaaagtg gaaggaagaa tttgagaagt tgagaaccat cattcttgac 529501 tgtgagctga ctgaagattt taagtggatg catccttgtt acacatatca taataaaaat 529561 attgttttaa tacatgggtt taaagaatat tgcgcgcttc tgttccacaa aggcgtctta 529621 ttacaggata cagatggaat tctcattcaa caaacggaga atgtacaggc ggcgcgccag 529681 attcggttta caaatgttca ggaaataaat gagctagaaa acattttgaa agcctatatt 529741 cacgaagcca ttgaagttga aaaagccggt ttgaaagtgg atgttaacaa aaatattgaa 529801 ttgaacattc ctgaagaact tcaaaataaa ttcgatgaaa tccctgcatt gaaaattgct 529861 tttgaagctt tgaccccggg acggcaaaga gcgtacactc tttatttttc tcaagccaaa 529921 caatccaaaa cccgagaatc gagagtcgaa aaatatgtgc aaaaaattct cgatggaaag 529981 ggattaaagg attaggcacg ccaaggttca ggctaaagga atagcatcat agcgtaataa 530041 gatcatttct atagaagaaa aacaagcata gtaagatgct tgttttttct taggacaaca 530101 ttcacttact gctgaaatgc ttctaacatt gtatgccact agacagcgtt ataaaatatt 530161 aatgcaacac ctagaaatct atccaatgaa atagctcaat ggtatggctc attacattta 530221 gaatgcctag gagaactaat agaaccggaa gatttttagc aagttactac actccaaact 530281 ttgtttttgt attaatatac cttattaacc attgttttta gtcaggtgca gacaaacgaa 530341 tactgattaa tgaatcatca tgatatcaat gagccgcttg attttttcat cgtcgcctgt 530401 atcaacgtac actgtttttc tgttttttat gatactctca gtcacttccc gcatgacgcc 530461 tttttctata tcatcagcgg aatcccagcg taaaggcaca ttatatacat gaattgtgcc 530521 atccccattg ccatgataag tgactgatcc atccactaaa cgagaacctg ccaactgggt 530581 cacattttct ggatagctgg cacttgtatc atcattagga ttaattggct cgccagccgc 530641 aatatgtcga acatttaatt catctatctc ttgattaggt ccaagttgaa gccaaactct 530701 ggcatattca attttttccg aagagtatgc tgccaataca ttgtcttctt tgcttttctc 530761 ttctgctgaa gaggtatcat ttgcagcttt tgttgcggat tcttctgatt ctgttattgg 530821 ctccgcttca tccttgcgta ttttggtgct ctcttcaggc tcagtgtgtt tttcgtcagt 530881 ttgcacagca gaagcttgat ttgaaggttg ttgtgcttct ccatccttac tgtccgtaca 530941 tccagcaagc aaaatcataa gcagcagggc agtattgcaa taacatatct ttctgcgttt 531001 cttcattttt tcattcctct ctattaattc aggtcagctt catatataag tttatgtatc 531061 taaatattac catggaatag ataggatgat attgaaaact gtttaagaag aggaaacgat 531121 cttgaatagc atcgcgaaaa cctaagaatc ttaagaagtt ttgccccttt ttcttcaggt 531181 attgaatgta aagtgggata taaatgcaaa caaaaacgaa atgccttatc cacctcgtgt 531241 catggcagaa aaagtggggg atttattaga gcggatttga taatggcggc aggtaaatgg 531301 gtgttgactt atatgtctaa gcgggagact caagtctgct cgatcgcata caaaatacca 531361 agggccagca acccttggta tttttatacc ttcatgcatt tttgaagttt atgcttaaag 531421 gtctgcctta ctttgcaaat cgccgagctg ctgcaacgca catgataacg gcgatattca 531481 ctgctacgag tgcccagccc actttctcgt gcagaatcac tgaggcaagc agcagtccaa 531541 aaaaaggctg gagaagctgg agctgcccaa ccgctgcaat tcccccttgg gcaagacctc 531601 gataccagaa cacgaagcca atcagcatgc tgaataagga tacatatgca agactgagca 531661 gtgcgggaac gccgatcgcc gaccatgagt ccggcgtaaa aaagaacgac aatggcagca 531721 taagaggaag cgacagaacg agtgcccatg agatcacctg ccaattcccc agacgccgtg 531781 aaagtttggc cccttctgca taaccaagac cgcatacgac aatagaagcc agcatgtacg 531841 cgtcgccaag cggggatgaa cctcccccct gaatgagggc gaaacctgct actaacaagc 531901 tgccggcagc tgagaaaatc cagaagacgg ggcgagggcg ttcacccccg cgcagtacgc 531961 cgaagactgc cgttgcgagt ggaagaagtc caatgaagac aatggcgtgt gcggatgtga 532021 catgctgaag cgctaaagct gtcagcaacg ggaaaccaat cactacgccg aacgctacca 532081 ctaacaatga aatgagatct cttttggcag gatgctgctg ccggaagatg agaaggagac 532141 ctcccgccag tacaccagct atcgcagcac ggcaaactgt gagaaataac ggatcgaagt 532201 ctgacacagc caaacgggtc gcaggcagcg agccgctgaa aatgagtacg cctataaaac 532261 catttatcca gccatttgtt gttttgttca ttataatcac tccacatatc tttcttgttc 532321 attgtctgta ttttcttaac aaaaccagca gctaaggatt acaatgacta taaactggaa 532381 ttggcctttt ataaacagcc agttttcata aaaaaatgca taccagttag gagaacaacg 532441 cgcaaatgga tatcacgcct tttttgaata gaactctgga tattccgctt tatcagcagc 532501 tttatcggta ttttaaagaa aatatgcatc ggggccgtat tcaaaaagga atgaagcttc 532561 cttcaaaaag actcctggcg aatcagcttt ccatcagcca aacgactgta gaacgtgcct 532621 atgaacagct cgctgctgaa ggttatattg tgagcaagcc aagaagcggg tggtttgctg 532681 attatcatga ttctgatttt gcttatgata gaatgccaag cacaacaccc attcaacaag 532741 aagcagaaga aaataaacaa tggattgatt ttcattatgg gaatgtagat tcttcttact 532801 tccctttttc cgcatggcga aaaagcatgg tcaatagctt agaccaatat ggacacgagc 532861 tttatcggcc gggacatgtt ttaggagagt ttgagctgag aacactcatt gcagagtacc 532921 tgtatcaatc tcggggggtt cattgcggcc ctgaacaagt gattataggt gccgggaacc 532981 ctattctgct gcaaatcttg tgccaagttt ttgagccgaa tatttctata gggtatgagg 533041 atcctggtta tccaagagca cgcaagattt ttgaagccaa ccgcatgaat attgttccta 533101 taccagtcga tgatgaggga atctgtatac agaagatcaa agaacagcag ccaaaccttg 533161 tatatgtcac accttcccat caatttacgc tgggaaccat aatgacaata aacagaagaa 533221 ttcagctgct caaatgggcg gccgaaaatc aatcctttat catagaggat gattatgacg 533281 gggaatttag gtacacagga cagccggttc cttctctgca agggcttgat cagcataacc 533341 gtgtcattta tatgggcact ttttctaagt ctcttttgcc ctcgctgcgt atcagctata 533401 tgattcttcc ttcgcctctt ttaaaaaagg gtcatgaaat cacgtcctta tataagcaga 533461 cagtgtcctg ccacagtcag ctaaccctag ctgaatttat aaaaaatgga gagtggcaaa 533521 aacacatcaa cagaatgaga aaactttacc gcaaaaaaag agccattgta ttagaggcag 533581 tgcaaaggga attaggagag catgtcagaa tccgcggaga aaactctggg cttcgtatct 533641 tacttgacgt ttatttgcca tttggtgaaa aagagttaat tgagaaggcg aaaaaacatg 533701 gagtaaaaat ttatcctgtt tctctttctt atcaacatca tcctcctaca aaaacggtct 533761 cgctcgggtt tgcaggggtt tctgaatccg acataagaga aggcataaaa aaactgaagg 533821 ctgcctggaa gatatgaggg agctttcagt ttagcaaaac ggccaagtga cgactaagtg 533881 ttgagagctg ttcaatattt tttaagtata tgatgagtgc ctgcagtcca ggccacgata 533941 cgtctgttta gcgaaaaaca gaatttttta tttgctcctc acagtgctaa aataaacaaa 534001 atagacaatt gaaaaaatag aggtgtaaga atgaagttag atgagtttac aattggccag 534061 gtcttcaaaa cgaaatcatt aaaagtatca aaagatgata ttatgcggtt tgcgggtgaa 534121 tttgaccctc agtatatgca tgtagatgaa gaaaaagcga gtaaaggcag atttaatgga 534181 attatcgctt ccggcataca aacactggcc atatctttta aactttggat tgaagaaggt 534241 ttctatggag acgatattat agccggaaca gagatgaatc atatgacatt cataaaaccc 534301 gtatatccgg atgatgaatt gtttacaatt gttgaggttc ttgataagca gccaaagaga 534361 aatgaattgg gaatactcac agtattgcta tctacttata atcaaaaaga agtaaaagtg 534421 tttgaaggtg agttatctgt attgatcaaa cgataactca gaaagcccgc ttttcgcggg 534481 ctcgattgaa gcagatgggt gaaagatgtt agcgggtttc ctttgaaaaa taagaggtta 534541 aaacatcata aacaataggc aaagaagtaa atccctcatc ttctagaaaa tgacctccgt 534601 gctgaacttc atataacgca gcatcaattt gttgtgccag atccttgctg aatgaaaaag 534661 gcacaatttg gtcgtcctta gaagcaatga cagcacggtg cttcgcggac tcgatgattt 534721 tttgatgatc aaacgatccc tgtgtaaatt catctaacat ctgtaaagtg ggcaatgatt 534781 tggcaaagcc ggaaacaagt atgattccgc caagctgttt tcgtaattga agatgttcca 534841 aaaatctcaa aatggcgggg caacctaagc tgtgcgcaac caaatacgta ttttcatgta 534901 aagtgtgctg atataaagag agtgtatcca gccaatcctc aagtcttggc tggagcggat 534961 taggcatgtt taaaatgtct gcttggaccc catctgcgag cagacgtttt ttcagccaag 535021 ggaaccaatg atttgttgag gaggctctgt agccatgaat gatatagact tgttttgtca 535081 ttatttcctc ctaagaaata ttttcattca gtataaaatt cctctcattg ggaaacaagt 535141 acgcactttt ttgtaagtag ctttacatat gaggccctcc ttgtgccatt ccccacttac 535201 acatctcatc tatgagggga tacaaagatc gccctctgtc agataacgaa tactctactt 535261 tcagtggggt gtgagaaacc tcagaccgat gaataaggcc gtcagtttgc aattccttaa 535321 gctgtgcgct taacatttta tgggtgatga agggcatagc ccttttcagc tcgccgtatc 535381 tcatcgtttt ttcacaccct aactcataga gaattctcat tttccatttg ccccctataa 535441 gagataaggt gtattcaaat ggggcttgtt tactgcggca caggctattc attgtaatca 535501 aacctccttt tttaagtatc atatcagaat aaattaggat tttcggtgtt gaagtttgag 535561 ggcgattcac gatctgaagt gaaaggggcc gcttgctcaa caggcggcac ggtacatgaa 535621 tgttctaagt caaagagggt taccttactg ttagttactt tatttaaaaa aacgcatgtt 535681 tttagctgaa aatatctatt atggtatatt taaatataaa gaaatatttg agaaatgagg 535741 aatggtatga atacacccaa aaaacataag aaatttaaag cgaaaatgat tctccaaatc 535801 atcatggtta tcattggagg aatcatagcg gcatatggac tagaaacagt gctcattcca 535861 aacagtgtat ctgatggagg ggtgacgggt cttagcatcg ttggttcaca gctattcaac 535921 ttgccgctgg ggattttgat tgctgtgatc aacattccat ttgtctggtt aggatataag 535981 caaattggga aaagctttgc attattatca attatcggaa tcgtatcgct tgccgcgggg 536041 acaagctttt tccaccacac acccgctatc atagaaggag ataccctgtt aattaccgtt 536101 gtcggcggga ttatccttgg attcggaatg gggctggcgc tgcgtaatgg cggcgcatta 536161 gatggaattg acatgcttgc tgtgctgcta tcccgaaaac tgccattcgg aacgagcgat 536221 ctcattctat tcttaaacct atttgtgttt atttttgttt ccacagtatt tggcttacaa 536281 ggggcattgc tttcagtcat tgcttactac attgcatcca aagtgattca tgttgtggag 536341 gaaggcttaa gcggctctaa aacctttcaa attattacaa cccaacctga attaatggta 536401 gagacaatac gtgatcaatt aggccgaagc gccacatata aagaagctta cgggggtttt 536461 tcccacgaga aatttaaaga aatcacatgt gtcatcaacc gtttagaaga aaccaaacta 536521 aaggaaatta ttaatgatat tgataaaact gcctttgtta ccgtgtatga tgtagctgaa 536581 gtgaagggca gcaattttag aaatcttaat catcactaaa aaatagaatg acctttttaa 536641 ccgtaactga catgccgcgg gtaatttaat caaaaacact tttttgaggc ttgtgggtga 536701 ataaccggtg aaggtctgaa tcacagaaat accaagggcg tcaaaaccct tggtattttt 536761 tctggttatt agattttatc ttcagcttta cgtgctgctt cgagcttatc aatcctgtct 536821 ttatattttt ctccccagtc cttcatgtgc aggataacag gttctaatgt tcttccaaac 536881 tcagttaaag agtattcgac ttttggaggg acctgtttat aaacctcgcg gtgaatcacg 536941 ccatcccgtt ccaattctct taattgtagc gtgagcatac gctgggtaat ttttgggtat 537001 agttttcgaa actcattaaa cctcttttta ccgtcaatga gatgataaag aagaatgcct 537061 ttccacttac ctccgatgat atctaatgtt gtctccaccg gacatccttc aaagtcatca 537121 gaagaataat caatgccgag tttacgattt ctcaagctgt tcactcctaa tagtatactt 537181 tttgatacta tatacattca atgtgcgtac tttttatatt ttaatataca tcatataatg 537241 atgtcacatc taaggaatga aaggaatgga tcatatgaaa acactcgtac tcgttgtaca 537301 tccgaatata gaatcctctc gtatcaataa aaagtggaaa gaagccgttt taagtgaacc 537361 agatgtaact gtccatgatc tttatgaaaa atatcgcgat caaccaattg atgtggaatt 537421 tgaacaacag cagctcctgg cccatgaccg tatcgttttt cagtttccat tatactggta 537481 cagcagccca ccgcttttaa aacagtggtt tgatgaagtg tttacgtttg gctgggctca 537541 tggtcccggc ggaaataaat tgaaggggaa agagtgggta actgccatgt ccatcggttc 537601 acctgaacac tcttatcaag ccggcggata taacttgttt tcgataagcg agctgacaaa 537661 accgttccaa gcatctgccc atttagtagg catgacctat ctgccttcct ttgccgaata 537721 tcgcgccaat acaatcagtg accaagaaat tgccgaaagt gcgaatcggt atgtaaagca 537781 tattacaaat atagaattaa acccgaaggt tcgcctgcaa aggtatttga aacagctgga 537841 gagtgtcgat ttaacataaa gattgatttt tgaaaatcct gtactcacca agcaggattt 537901 tttcttgttc agcagaggga ttttaacata tagcaaaaaa agaagaagcc accaaaaata 537961 agctatttgc ttggtcctga ctgcttattt ttggtgaaat acttatttct ctgtgatgaa 538021 ataaagcaaa gcgatgaccg gaaaagcgat tccaatccat aatgctgtac tccatccgcc 538081 tgaggcatat gcccatcctc caattgatga ccctatcgca ccgcctagaa agaagatcgc 538141 catgaataat ccgtttaatc gactgcgaat ttcaggcgcc aacgaaaaaa tagcacgttg 538201 actgagcaca aggtttgcag atacacccat atctaacaga atagcagcgg ccactagaac 538261 tgttataccg acgggggagc tgctctgaat catgagcggc agtaataaag agacaacgac 538321 aacaccgaga gcgattccag tggcaagcct ggttaagcct cgatcagcca ggcggccgcc 538381 tattggtgca gtgactgcac ccgcaatgcc caccaatgcg tagagtgcta ttgccttctg 538441 agaaaaatga aaatcaggac cggacaataa taaaggaaca gttgtccaga acaagctgaa 538501 agctccaaat acaaacgcat gatagatggc acggcggcgt aagactggag tcgtgcgcag 538561 cagcttccac attgaaccga gtaaggcagt atagtttgta tttgctgttg gttttctggc 538621 aggaagcact tttgataata cgatggccag gataacactt accacggcgg acaaagcgaa 538681 tattgcattc cacccccaga tatcagcgac tagactagat atcggacggg aaagcataat 538741 accgagtaat aagccgctca tgacattgcc aacaacccgg ccgcgtgcag cgtctgatgc 538801 aaggtatgat gcaaatggaa caagcacttg ggctgcgatt gatcccaatc cgacgaaaaa 538861 cgcagctgct aaaaacagtg ttccatgctt cacaaatgct gttagtgtca aagccgctgc 538921 gcttagaagg agcgatacaa caataagttt tttgttttcg ataatatctc ctaaagggac 538981 aaggaatagt aagccggcaa cgtatccgat ttgggtgagt gtgacaatca atccagcacc 539041 gcttggagaa agtccaattg ccttactaat taatccgacc aagggttgtg catagtaaag 539101 attagcaaca atgataccgc atgcagttgc gagaagaagg gttaaactgg gtgaaatcct 539161 ctgacctgct tgtttgtttc cattagccat atgaatgaac tcctttttaa gtggtttttt 539221 gagtgtaatc atgacttctc acaagtgatt ttataaactg aacgttcagt ttcgtcgatt 539281 aataaaaata atatactaaa cgttcagttt tgtaaatgga tttctgtttt ctttttttat 539341 tcaatttaag tatactgaac gtatagttta tattgcggga aggaatgatt tatgtgcaga 539401 gtaaacgagg gcggccgcgt gatgaaggaa cgcataaggc gattctctct gcagcctatg 539461 acctattgct ggaaaaaggc ttcgatgcgg tgacagtcga taaaattgcc gagcgtgcga 539521 aagtgagtaa agcaacgatt tataaatggt ggtctaacaa ggctgccgtt atcatggaca 539581 gctttctttc gaccgcgacg gacaggctgc ctgtgcctga tacagggtcg tcagtacaag 539641 atatagtaac ccacgccacg aatttagcta ggtttttgac aagccgggaa ggaaccgtta 539701 ttaaggaatt aataggtgca gggcagttgg atgaaaaatt ggcagaagaa tatcgcacgc 539761 gatttttcca gcctcgccgc ctccaagcga aaggccttct agaaaaggga attcagaaag 539821 gtgaattgag agagaatctt gatattgaag taagcataga tctcatttac ggaccaattt 539881 tctatcgtct gcttataaca ggggatgagg tgaatgattc ctatgtgcgt gatttggtga 539941 tgaatgcgtt taagggagtt caagctacct ctgctacaga gagtatgtag ctgataagaa 540001 ctgcaaaagc tgcggattat atgacaaatt ggttccatcg tacagtgaaa tataagattt 540061 ttgttgctga gcggaatcat cgagggaaaa gttctcttat cggatgtcga aaaagaagtc 540121 attcaatcgt gaatacataa catcatatta ttacattcct tttcatcgat tggaacaagg 540181 gttctatact tcaatggaat accgcaaagt tggagtattt aaacaacagg ggaaaatcga 540241 tggccattat gtaggtgtca tggcaatgga aaaaatactt gcaatgtaaa caggcctcta 540301 aagagacctg ttttttaata tccagatgat tgtctagttt cagcttgggc tctatgacca 540361 ctcccataac tgaaatagtc taatatttat accagaaggg attgtttata taaataaaag 540421 tttatataat gacgggggcg ctaaggaaac gcggggagcg actcaggttt tcgtttcaaa 540481 gttttgatcc ttaagatata cggagcgcta catatggaaa cgtaaagggg aatgtataat 540541 catttggcgt gtatataacg atttgcttat atattgattt gggaaggagg agctcatatg 540601 acgattgatg ttgcggcgat gactcgttgt ttgaaaacac ttagtgatca aactaggctt 540661 atcatgatga gattatttct tgaacaagaa tattgtgtct gtcaattggt tgatatgttc 540721 gaaatgagcc agcccgccat aagccagcat ttgcggaaat taaaaaacgc aggttttgtg 540781 aatgaggaca gaagaggcca atggcgttat tattcaataa atggttcctg tcctgagttt 540841 gatacattgc aattgatctt acatcaaatt gatcaagagg atgaattgtt aaaccatatc 540901 aaacaaaaga aaactcaagc gtgttgccag taaggaggca ttagattgac atcaatgatt 540961 ttggcagtat tcatcttttt attaactcta gtattggtca tatggcagcc gaaaaattta 541021 tctatagggt ggtcagcctg tggaggcgca gttttagctc taatagcagg tgttgtcaat 541081 tttcatgatg tgttaactgt gacagggatt gtttggaatg cgaccttggc ttttgtggcc 541141 atcatactga tatcgttaat tcttgataat atcggtttct ttgaatgggc agcgcttcat 541201 atggctaagg ctgcaaaagg atacggtgtg cggatgttcg tttatgtatc tctattagga 541261 gctatcgtcg ccgcgttatt tgcaaatgac ggtgcagctc ttatattgac accaatcgta 541321 ttagcgatgg tcagagcatt acattttaat gaaaaattag tttttccttt tatcattgcc 541381 agcggattta ttgcggatac cacttcgctt ccttttgtag taagcaattt ggtcaacatt 541441 gtttcagcgg actattttca tattacgttt attgattatg catccagaat ggttgtcccg 541501 tacctgtttt cgctgctggc gagcatcatt gtactttacc ttttctttag aaaaagcata 541561 ccaaaacgct atgatctgac tgaggttaaa aaacctgttg aagcaattaa agatcaaaac 541621 atgttcagac tgtcatggta tatcttaggg ctgctgttaa ttggatattt tgcaagtgaa 541681 tttttttcta tccctgtatc agtggtagcg ggcagcattg caatcatttt cttaatcgct 541741 gcgcaaaaga gtccggccgt ccatacaaag aaagtggtga aagaggcgcc atgggctatc 541801 gtattctttt caattggcat gtacgttgtt gtgtatggtg tccgaaatgc cggattaacg 541861 gatgtccttt cagatgtgat tcaagccgca gctgatcaag gattgtttgc tgggacaatt 541921 ggaatgggct ttattgcggc gattctttct tccattatga ataacttgcc gactgttatg 541981 attgacgcat tggccattgc cggtacagat acacatggga tgatgagaga agcgcttatt 542041 tatgcaaatg tgatcggttc agatttaggg cctaaaataa caccgattgg ttccttagcg 542101 acattattat ggcttcatgt tctttcgcac aaaggtatga agatttcctg gggcacgtat 542161 tttaaaacag gaattatcct cacgataccc actttattga tcacacttgt cggcctgtat 542221 atttggctgc tgataatcca ttcttgtttc taaaaggaca aggtcactat atcaaggaaa 542281 acaatgcact ggtaactctt gccgcagcca aatggctgaa gggtggggga gaaaatacct 542341 tggggctaag tggaatgtgt acagcgcagg aatcgaagct caaggatgac atcgagtgct 542401 gtcaaagcaa tgaaagaagc agggattgat atttcaaatc aaacatcgga gaaatttgat 542461 gatccggcaa aagcacacgg aacagaagaa gtgtttccaa agggtccgtg atgaaattgg 542521 tgaccgttta aaacagtttg ctgtaactgg ggaataaaga atcgatatat tcagcgtttt 542581 cttgggttat ataatacaat gtgttgttca acaggtgtct gcgagctgag tgcagacacc 542641 tgtttttgtt tttatttgtc tgagattcgt aacagggaag ttatttagct ggtgacagag 542701 gaaaattgat ttgtgaacag aatcatgaag gagacggtgt tttaaaggag ttgtctgttt 542761 tgcaggaatt aacaaaaaaa aaatacagta gcttaaaaac aatgtttgat gacaaatatt 542821 gtcccacatt tgtctattca atattagacc aaaccattcc gggagctgtt tatgcagatg 542881 atcaaacctt tcctaaatcg ttttttatag gaactgaatc aggcatttat tttattgcgg 542941 gagaccaagg gaatcgggat tttcatgatt tcattgcagg atattatgaa gaacaagtga 543001 aatcatcaaa acgatttacc ttgttttctt ccagtgatac atgggatagc gtactgaaac 543061 ccatactgaa agatgactta aaccaaatga gaagagctgc attttcttat caaccaaaat 543121 ctttcaaaaa gactttgcaa ctgccaaagg ggcttgtatt gaaaagaatt gacgaagaca 543181 tcatttcaca tagcacagcg tttaacagcg cgtattatga ggagtattgg aattctgtct 543241 cacagtttgc ttcaaaaggt tttggatttg ccgtattaca tggcaatcac gtagtaagtg 543301 agtgtacctc tatattttta gggcataatc gagcggaaat ggatatctat acacttgaag 543361 aatatagagg actggggtta gcttattgcg tagcaaatag gtttatagcg ttttgtatgg 543421 aaaatgggat tgttcctagc tgggattgtg atatttgcaa caattcgtcc attgcattag 543481 cagctaaact agggtttaag acggtaacgg aatacactat ttactactct ggctaacctt 543541 aatgaaagaa ccttaaaagg agataccaac cgatgttggt atcttttttg ttttagagtt 543601 tttttaccct tttagcagaa aaatgggtga tgaaaatctt attcatttta tttactttta 543661 ggtaggtaaa acataccccg ccaactgtaa ccactccgcc tagcagagag agcagtgtgg 543721 gtatctcgcc gatccagagc caagatatga tcaaggctaa agccggtgta acataaagtg 543781 aaagggttgc ttctgaagca ccgacgaatg aagtgacata tgctagtgcg aagtaaggaa 543841 taaccgtcgg caataatcct aagtaaacga tagacaaagt tgcgcttatt gaagcgttca 543901 tcatctcttc gcctaagcct ggcagaaaca caagcatagg tattgttccg ccccaaatgg 543961 tgaatgtaac gaatggaata aaaccatatt tttttatata gcgggcttga aaaacgaaat 544021 aaatactctc cgaaaatgct gccagcagga tgaccaagat accgctcatt gaatatgtaa 544081 agtctcccgc cccaaatgca atcaataata cacccaataa actgatcata gagccaagcc 544141 atttcgtaaa tccaaaatgc tctttataaa acaggcggga tagcatggct gagaagatcg 544201 gtgccgtagt aacgagtaag cttgcaactc cggcactaac tgttttttca ccgatgttca 544261 gcaaaatgtg atagaatgca aatcctaaaa accctaaaag aaaaatggca ggaatgtctt 544321 tcaagtcggg taggcgcatc tgagtcaaaa cagcaaaaag caataatgcc atagagccga 544381 ttaacaaacg aaataaagca aggtgttctg gcgtgtaccc ttcaagtcct gcgcgaattc 544441 ccggaaaagc agatgcccat aaaccaatca tgagactatg agatatcatt atttgaactg 544501 ttttctttcg cattcctctc actcctcttt acaaaaacca accagttatt taatgtgttt 544561 ctatactaat aaagatttga tgatatggct tcaaccagtt caatagattt tgacccaacc 544621 aatttatttt aaggagaccg attctatgag ctttccagaa gaaaaaaaga tgaaaaagct 544681 ccctaagtac agacaaatcg ttcattttat taaagagaaa ataggaaatg gagagtggcc 544741 gattggaagc aagattccaa gccagcgcac gcttgcaaaa gattttcagg taaatcggag 544801 cacagtgatt acagcgttag aggaattgat ggccgatggg ctaatagaag gcacaatggg 544861 gaaaggcaca gttgttatca acaacacatg gacactgatg gctaagaatt ctgctcccga 544921 ttgggatcaa tatgtcacct ctggcattca gatgccaagc cgaaaaatcg ttcaagagat 544981 aaatcaatca gaatcaaata cagaccttat acagctcagt aaaggtgaac tttcagctga 545041 gatttttcct ttggctgtta tgaaagagat gatggggaag gtatctcaac acatggaggc 545101 attcggatat gaagaaccaa aaggttactt acctttgagg gaggcattaa gcaactattt 545161 aaaaaccatt ggaatcaacg tctcatcttc ttccattctg attgtctcag gagcgttgca 545221 agccttgcag ctgatatcaa tggggctgtt acaaagagga tcaaccgttt atcttgatca 545281 gccctcctac ctttattcat tacacgtatt tcaatcagct ggtatgaagc tgactggact 545341 tcctatggat aatgaaggac ttttgcctga aaatgttcat ttaacaagag gagagcgggg 545401 aagggctatc ttatatacaa atccatgttt tcacaatccg actggtattc ttatgtctaa 545461 aaagcgacgg gaagaaatcc tagcagtaag tgagaataca cagcttccta ttattgaaga 545521 tgacatttat cgtgagttat ggatcgatga aattccgcca tatcctatta aaacaattga 545581 taaaaatgga cacgtactgt acataggaag tttatcgaaa acattaagcc caggtttgag 545641 gattggatgg atcgtcggac cggaaccggt gattgaacgt ttatctgaca ttaaaatgca 545701 aacagattac ggatccagtt cgctatccca gagagtagcg gcagagtggt ttacttccgg 545761 ccactaccag cagcatgtag aaaaggttag gcagcaatta aaggtgagaa gagaattggc 545821 cttgagtgct ttagaaactc atttgaaaga agtggcgaca tggaatatcc caaaaggagg 545881 gttttttgtc tggataaaaa tattgccttc catatcaatg aaattacttt atactaaagc 545941 cttatcaaaa gggattctga tcaatctcgg cagtatctat gctcaggaaa aagggaatta 546001 tattcgctta tcatatgctt atgcatctct tgaagacctt caaaagggga tttatgagtt 546061 gggtttaatg attaaagaat tggcaagcag gtaactttta tatccttaaa tggatgtttc 546121 actaaaaaag agatcaagcc taatgatcgc ttgatctgat aataacaagg gttactagaa 546181 tagaccaaat catggttcgg tcttaaaata atcatgtctc tgaacgaaaa gtctttccga 546241 cttctcttcc taaaccaaag tagtgtctga aattatagat aagcgggctc catttggaag 546301 ggttgatatg gttttcgtcc agaatgatac tttcctcggc atgaaaatgt agtgcctgcg 546361 tctctacaat tgcgaatgac gattcatatt ctggaagccg aatgtgtttc acttcggctt 546421 cgatttggat agggcattct ttaattcgtg ttggtgatac tgtttttgat tgtaaaggcg 546481 ttaaccctgc tgcctcgtat ttttcttttt tatatgtaaa tccgatctgc ttctttaaag 546541 gcggtatact cttttttccg ctataagatg aaattctttc aacgttttcc cataaatccg 546601 ggccaggcaa gtttatgaca cactctttgt gtctttccaa attgtcgatg gcttttcctc 546661 ccagtcctac tccaaggatt atataatgtc caagagccca agaagaagac ataggactaa 546721 tattagtggt tccatcctca ttcaatgtgg ttagaagaaa tgtcgaggta ccataataca 546781 tgatcttggg tttgatttcc ttaaatcgac gagtgtcttg ttttttgatg tccaacgttt 546841 tttcctcctt gtcacgctta catttatatt gtaaaggatt aacatttcaa ctatcatcga 546901 aatatgaatg taaggaggaa aatcatgaat cctaatattg caaaaatctc ttcgttgcta 546961 tcagatccct cgcgttcttc cattcttctc agtctgatgg atggaaggat acaccctgcg 547021 ggagagcttg catatctcgc taacattaaa cctcaaactg caagttttca cctgaataaa 547081 ttgcttgaag caaagctgat tagcgtagag aagcatggga gacatcggta ttacagattg 547141 gctgactcag atgctgcaaa tgtgatcgaa caattgcttc atattgcgcc taaagcaaaa 547201 gtcaaatctt taaaagagtc aaaagagaaa aaggacttgc atttcgcccg gacctgttat 547261 gatcatttgg caggttatgt gggcgtgcaa atggcacatt cactagttga gcaggggatg 547321 ttaaaaaaag ttgatttaaa ctttgaggtg acttcagagg gtgctttatt cttttcgaag 547381 ttaggcatca atgaagagca acaacggaat aagaggagag cctttgcccg ctgctgtttg 547441 gattggagtg aacggcagca tcatattgca ggagcattag gaaacgccct attggtgcgc 547501 atgttagaag aagaatggat cgttcgtatg cctaaaacga gagcgattag gattacacaa 547561 agcgggaaaa tcgcgtttga aaagcaccta aacgtgaaga tttaggattt tgaagcggaa 547621 acatcagatg atgaggcacg atatctagga ggagtaagat ttgttctaat cttactcctt 547681 cttcttattt tgaagcagct cgattcccca ttgcaataga gatgcggttc caactgttta 547741 tttgattaat gatcagaaca aggtcaacat attgttcctc atcataatgt tcccgcaccc 547801 gatgatatag ctcatcagga acccttttag atggaatgag cgtgatgtgt tcagatagtt 547861 cgagagccgc tttctcttca ggtgagtaaa aatcacattc attccaagca tgtaaacagt 547921 aaattcgctg ttcagtttct cccattttgc gggcatcgga cgtatgcata tctatgcaga 547981 aggcacagcc gttcatttga gagactctga ttttgattag ttctctcgtc gttcggttaa 548041 ttgaggattg tttcgtgtat ttctccatat ccatcatgat tttcatacct tcaggtgcaa 548101 tctcatagta ggacactctt tgactcataa agcaagactc ctttccatag aatacctaga 548161 ttgtatcccg gtattgatca ttttaccaat gtgcggtttg aatgacagct gtttcagcgt 548221 cttttggaaa gaagcttctt tgaataaaaa taagggtagc cagcaatgat gagtggagct 548281 gctaatgcaa gcagtatcca tgagcctgat tggctgtctc tagtgactct aatgaatata 548341 taagtaccga tcagaaaata taataaagca cctagaaacc aatacatgtt cattcctctt 548401 tttccttgct ttttggttgc gcatttttgt ctgtcatatg gcttaatcga tcagggttct 548461 gattttttaa taccttttcg gtccggattc cttttctctt taatgataaa attgtgagat 548521 caatcgattt caatgatgat cattccttca atgaatagta agttccttat gattttaaag 548581 gtaaatttga aaagataaaa cgtacataga ggcagaacgt tcatgtacgt ttgggcaatg 548641 atcacttgtt ggaaactcta atgtttccct gcacctgata ttgttgtgtt ccttctcttc 548701 ctataaaatg attggataca tgtatgtttg cacgttgaaa tatgggttcg attttcatga 548761 atctctattc ggtgaaacag gtaaaggaag tggataaggt ttgcttataa ggaatccttt 548821 taaagataaa tattactcac atgataggcg ggcattaaac atgcttgcac tcagagtgcc 548881 gggcctggct tttattctca tgatctatat agcctctatc gtgctgcaat ttgtttctgg 548941 gggctggtcc attttattgc tttatgcgtt taccatatta atcgccattt ttgctttgct 549001 tcattggcac tcatatcgct gggttaagaa aagagtgatt ctgtatttcg cggtacaagg 549061 tttgatcacc tttgcacttg ctaatctcat gactggcttc tttatacttg tgattatcgg 549121 cctttatgca tttttaattg gacaaattat aggaatggca gacagaagaa ggacttttct 549181 cattctttat ctattgctgc tgctggtcat aaattcggcg tatcaccttc ataaaggtga 549241 agttttgcat tttattgtta ttgctgcgcc gatcatgatt gtcatcatca cttatgccgc 549301 aacatttttt gcccaagtcg atgaaaaaat aaaagctcaa ttgactcttg aaaggctgga 549361 gctggctcat cagcaggtag aacagctgac gctgcagaac gaaagacagc ggatggcccg 549421 agacttacac gatacgcttg ctcaaggtct tgtcagttta aatatgcagc tggatgcgat 549481 tcatgttcat ctcgccaaag gcaacacaga gagagcgaag gaaatcatac aacaatcgat 549541 gaaaagagtg aaaagcacaa tagctgatgc acgttcagct attgacgatc tccgcagcaa 549601 atcagaagaa atcggtgttt taaaagaaag aattacctcg ctaatggatc attttataga 549661 gtcgacaggc atggcttgtt tattagatta cagattgcat caggtgctgg atgtgcgtac 549721 agctgaaaac tgttattaca tcattggaga atgcatgacg aatgcggcaa agcatgctga 549781 ggcgaaaaca atctggatat ccatttggga tgatgaaaag ggaaggctcc atttaacagt 549841 taaggataac ggcaagggat ttgatgttga aaaaggaaag aaaaagagag gacattatgg 549901 gcttcttggc atacaagaac gcgtcagggc aataaatggc caattcaata tcaagagtac 549961 aaaattgaaa ggaacacaaa ttgagatcac tgtaccaatt cagggagaga tgcaagatga 550021 ataaggtttt aatcgttgat gaccatcttg tcgtgaggga aggtctgaag cttttaattg 550081 aaacgaatga tcaatacacc attataggag aggcggaaaa tggaaaagta gcagtccgtc 550141 ttgcagatga attagaaccg gatatcattc tgatggattt gtatatgccg gagatgagcg 550201 ggttagaggc cattaaacaa ataaaagaaa aacacgatac ccccatcatt attttgacta 550261 catataatga agatcactta atgatcgaag ggattgaatt aggagcgaaa ggatatctgt 550321 taaaagatac gagttcagaa accctttttc acacaatgga tgcagccatc agaggaaatg 550381 tgctattgca gcctgatatc cttaaacgtc tgcaagaaat ccaatttgag cggatgaaaa 550441 agcagcgcaa tgagacgcag ctgacagaaa aggaagtcat tgttctaaaa gcaattgcta 550501 aaggtcttaa aagcaaagcg attgcctttg atttgggcgt ctctgagcga acagtaaagt 550561 ccagattaac gtccatttac aataaattag gcgcgaattc aagaactgag gcagtaacga 550621 ttgccatgca aaaaggtatt ctgacaatag acaactaaac tgcatatttg aaaattgccc 550681 aaacgtacat gcccgaatgt acgttttttt catttcattg tcaactacaa tgagaaagaa 550741 tgtgatcaag caatgtgttg aaaggagatt atcatgtcaa aaatgttata tacattagga 550801 ggatgggttg ctcgcaatcg cataaaagca atatgtgcgt ggatcgttgt gttagttgct 550861 gcgataggcc ttgcagtgac cttgaaacca agtttttctg aggatatgtc catacctgac 550921 acaccttcgg aaaaagcgat ggatgtgatt caaaaagaat ttcctcatgg tcctgataaa 550981 gggagcatac gggttatttt cggtgctggt gatggggaga aacttactgg gaagccagca 551041 aaaaaagcaa tagaagatac gttcaaagaa atcagtaaag atgattctgt tgactcgatt 551101 gcaagtcctt ttgtgacagg gacaatcgcg aaagatggca cagttgccta tgctgatatc 551161 cagtataaat catcagcaga tgatataaag gattactcta tcaaacactt aaaagacagt 551221 ttgaaaatgg ctgatgatga aggattgcaa actgagctaa gcggagatgt accgggagcg 551281 gagatggaga taggcggtgt ctctgaaatt gtcggcatta tcttggcttt tgtcgtttta 551341 gccattacat tcggttcttt attaatagca ggtttgccga ttttaactgc actgattggt 551401 ttaggtgtaa gtattggact ggttttgatt gggacacaag tatttgatat tgcttctgtc 551461 agtctttcat tagccggaat gattggcctt gctgttggta ttgattatgc tttatttatt 551521 tttacgaaac accgccagtt tttaggcgaa ggcatacaaa agaatgaatc aattgcgaga 551581 gccgtgggaa cagcgggaag tgcagtggtt tttgccggac ttactgttat cgttgcactt 551641 tgcggattaa ctgtcgttaa cattcctttt atgtctgcga tggggctgac agcagggctt 551701 agtgtactga tggctgtttt ggcttccatc acacttgtgc ctgcggtctt atcgattgca 551761 gggaagcgga tgattccgaa atcaaacaag aaaatagaaa aacaaagcac tgaaacaaat 551821 gtctggggac gctttgtcac caaaaatcct atcatgctaa gtgtatgcag cattctgatt 551881 ttgatcgtca ttagtatccc atctatgcat ttggaactgg gcttgcctga tgctgggatg 551941 aaagctaagg ataatccgga tcgccgggca tatgacttgc ttgccgaagg ctttggagaa 552001 ggatttaatg gccaattaac aatcgtagcg gatgccacaa atgctacaga aaataaggcg 552061 gaggctttcg cagatgcagt gaaagaaata aagggcttag accatgtagc aagtgtcact 552121 cctgcaatgc ctaataaaga agggaacttt gccatcatta cggtcgttcc tgaaacaggt 552181 ccaaatgatg tcacaacgaa agatttggta catgatgtac gcagtttatc agataaaaac 552241 ggagtagatt tgcttgttac tggatcaact gcagtgaata ttgacatttc agatcgcctg 552301 aatgatgcga taccggtgtt tgctgtactt attgttggct ttgcgtttgt attgctgacc 552361 atcgttttcc gttcgctgct tgtgccgctt gttgctgttg caggtttcat gttgacgatg 552421 acagccactc ttggaatctg tgtatttgtc ttgcaagacg ggaatctcat cgactttttc 552481 aaaatacctg aaaaagggcc gatactcgcg ttcctgccga ttttatcgat tgggattctg 552541 ttcgggttag ccatggatta tcaagtattc cttgtcagca gaatgcgtga agaatatgta 552601 aaaacaaaca atccagtaca agccattcag gctggattaa aacacagtgg tcctgttgtt 552661 acagcagccg gcttgatcat gatcttcgtt tttgcaggat ttatctttgc aggcgaagct 552721 tctattaaag ccaatgggct ggctctttcc tttggtgtac tctttgatgc ctttattgta 552781 agaatgacac tgattccaag tgtcatgaag ctgatgggga atgcagcctg gtatttgccg 552841 aaatggttag acaagattat tccgaatgtg gatatagaag ggcatcaact gacaaaggaa 552901 atacagccgg aaatagatca tgaacaaaag aaacaaatca gtgtgtaata gaaaaagcag 552961 atcttttatg atctgctctt ttgcttatgg tagtatttag aagatgaagt cggcagttaa 553021 aaggagacgc ttatggcgcc atcactcatt ttcgatatgg atggaacttt gtttcatatt 553081 ggcagaagct gcatcatact agcaggcatc ccaggagaag tgacatgatt ttttgacttt 553141 gcattcacta cttgatgcca aggatcttga gaatccttct tgaaaataaa ggattttaca 553201 actgatcata taagaaacct aaagaaacaa gcacacaaaa ccagctgcgg gttttgtcca 553261 agaaaaatag agtccataag agggactcta ttttttgaag tgcccggcta gaagcatatt 553321 gcaggacttt atgaatgcaa atcactatct tataagccct taccgtgaaa tgcctgtttc 553381 tgcattgaaa aaacgcatta cacgttcatt tacgtaagtg ggttgttcca tcgataaaac 553441 atgtccggca tttttaatga cttccgcctc aatatctgga acgaatgaag aggctcggtg 553501 cagggctgag tggggatcat agatgacttc atgttcacca agtaataata ggataggaac 553561 tcttgctgaa cgtaattcct catcggtaaa aacatacgga aatccgtcgg cattaggatt 553621 tggatttctt gatccatcct gccacattac ccctgcctta aactgcttca caaaaatcgg 553681 gtgcagcaca ttctgatcat tcatcatcca atttaagaat gtttcaactc catttgacgc 553741 tgtaaggcca agagcgtatt tgtagaaatc gtgatgaaat ggcaaaaacg tttctgccgg 553801 actcagtata gctgcgcttt ttactctctc aggcatacgt aaaaggaaat tcatcgtatg 553861 gagaccgcca agcgaaagtc cgatcatgtg ggacttttcg atccccagat tgtcaaacac 553921 atcaagaagc caattggcgt aatccgttct tgtaccgctt acattctcag gaatactctt 553981 gtttttatca cctatgatat caactgcata agttctgtat ttactgctcc aatcggcgat 554041 gttgggatac cacatcgtcg agctgaataa tgctccgtgg agtaatacaa gcggcggggc 554101 atcctctggg ccgcttgcaa tcacatgtgt ttgaccaaaa cgagtagata tatagaatga 554161 tttacaacgg accggccaaa gactaaggct ttcattataa gtttgataat agcggatacc 554221 gttgtcactt aattcgggaa tactagatga atggtttgac atacaaatgc ccctcccaat 554281 tttgtttaaa tgaatgtgcc gtttcgtgat ggggaatctg attttgatat aacagacttt 554341 atttacaata taatacagtt gttattagac gtcaaatcca agatgaaaag gaaaaaaacg 554401 attgaaacag attattgaaa atcaatataa cagaatatta acctcctttg tggagccgct 554461 tcattaaaac cgcaatccaa atgcatgaat cacaaaaatc acaacaggag ggatcaggag 554521 ggaaggcagc agattcagtg ttttgaactt cttgattcca agaatgctta gacctgaact 554581 gaggatgagt atgcctccca caattgtgat ttcattaata aggtctgtat tgattgcgct 554641 ctccattact tgtgcaaata aatagatgga gccctgccag gaaaataata caagtgcggc 554701 agccgctatt ccaaaaccaa aagttgaagc gagcacaatg gaggtgatcc catctaacat 554761 cccgtttgtc agaaggtatg tataatctcc atgcaaagcg gcttcaacag ggcctaatat 554821 tgacagcgaa cctatacaaa ataataagac cgcagttgat aagccctctg ctaaattgct 554881 tttagaaaat ttgttcacca gcttgttgaa tcgtaattct aaattgatga tctggcctag 554941 caaacctcca atggctaaac tcacgatgaa tagaatgggg tatttactat caggcaaatg 555001 ctgtgtaatg gcgttgatcc ccagtgcgac cgcagcgaat cccattgcct gcatcaaaat 555061 atcctggtat tcatctttaa tgcctttttt gaatatcccc ccgattatgc ttcctgcaat 555121 gatcatcact gtgttaaaaa tcgttccaaa cataagcttt ctcctccaaa aatcattcct 555181 gcataaaaaa taaaccctct agttagtaga gagtcaaggg agatcaaaac atattcatga 555241 gattatttga tgggcagcag gatttcagtc acgtaattat ctaggttatt cgtaatgcca 555301 taatcaatga gtgtgatttc gattgagtcc cctgctacct cataatgatg ttctttcata 555361 tatgccagta attttttgta gtatggttcg gcttctggat gtgacccttt aaacctaatt 555421 tgcagatatt ctcttgaagg aaagatgatt tctgaagaag ttttttcatt ttcatcttca 555481 agaatcataa atatactgga atatttgtca aactgttttg ctttcacatt tgctgcagaa 555541 atggataaac caatcttgcc tatgaatata tcttcgttta cattcaggtg ggttctcaat 555601 tcagctaacg aatgttcgat atcatggccg agaacatatt catgctgcaa ataggccaca 555661 cgcattgcgg gaagtttgat ttttgaaatt tgatgtaacg gcatgttaac ggcatcttct 555721 atatgtgtga tgcgtcggga gatctttcgt tcaatgcgtt ccaattcttt cttcttgcga 555781 tcaatttcaa cctgctggct ttttagtaaa tgaagaagag tgtttgtatt ttgagagtta 555841 taaaaatcaa gaagcttatt gattggcagg cctagggccc tcaaatactt gatggtatcc 555901 agccgctcaa actgttgggt agaataatat ctatagttcg tttgctcatc tttatattcc 555961 ggtttcaaaa ggccgatttc atcataatac cgaagagcag agattttcac attgaataac 556021 tttgacactt ctccaatcga aaaaaattcc ttcattctaa caacctttct gtcctatgat 556081 tgatatacac acattatata gtacggcgag tactaaaggt aaagtttgca gcataaagaa 556141 aaaactcctt ctaaaaagga gcttttcatt cttcgaaata aggatttaca tggatgagca 556201 cttcttctac atctgaaaac tgtcttttga tttcatttcg aatttcgcgg gcaatgtcgt 556261 gtccctgctt aattgtcaaa tcatgatcca aagataaacg gacatcaagc aatttatagt 556321 ggccatgttc tcgcgcgcgg attctatcaa ttcgttttac ctgatcacat tgaaaaataa 556381 cagctttata ttcctctatc agctcgggat caacactctt ttccatgagc acatcaacag 556441 acggcctgat taattccatt gaaatcttaa aaatgaggta agcaacgatt gcactggcaa 556501 tggcatcggc gtacaacaga taggaccatc cacggctgtt tccgatgata gccaacagga 556561 cgccgataaa agcggcaaga gaggcaacga tatcgccttt atgatcgtac gcaatcgcta 556621 taatcgcttt gctgttccat tttttccctt gctttataga ataacgatat aagatttcct 556681 tagccacgta cgaaatcaga gccgcaaaca atgcgctgta ttggggaacg cttggccctt 556741 taacaaagga cagaatcgct tctatgagga tataaacgga tacgatcact aagataattc 556801 ctacaatcgc ctcactaatg acttcagctt ttccgtgacc aaaaggatgg tcttgatcgg 556861 gcggtttatt ggaaattccg atcactgcca agactgcaat cgaagcaacg acatctgccg 556921 cggaatgtat tccgtctgca aacacggctt cactatcgcc taccagccca aaaaagacct 556981 ttcctgccat taagatcaga ttggcgatca atgcaatcaa agcaactttt ctgcttattt 557041 gttctctttc acttgccatt ttttcctcct ataaaactgc acaaaaaaat aggagtgctc 557101 tatatacgct ctccgtatcc tttcctgtgt aatcactttg tttatcatac caattcaatt 557161 tcgagtgggt ctatagcaac gttgtttcct gtttactaat aaataaggtg acagaaaaaa 557221 agttggagct atgctaaaaa ggtcatacag caaacaaatg agttcttatg taacaacagt 557281 gatgattcgc tattaaaatg ctgccgtcag tgaaaaattt ccacctaatt ttcaaaaacc 557341 tattgacatg agaagatctg tattttacta ttatctcata ttcaagatat tttaatttga 557401 gatatttggt cggaaagatc agcgatcaag cgcaactcta agtgttcaat cgttgtcagt 557461 tcttttacac aatattcaat atgatttttt ataacataat atctcgaatt cgagataaaa 557521 gggagtgtag cgtaatggct gaatttactc atttagtcaa tgaaagacga tctgcaagca 557581 attttctttc aggtcatcca atcacaaaag aagatctcaa tgagatgttt gaattggttg 557641 cattggcacc atcggctttt aatttgcagc atacaaaata tgtgacggtt cttgaccagg 557701 acgtaaagga aaagctgaag caggccgcaa acggacaata taaagtggtt agctcttctg 557761 cggttctctt ggtattaggg gataagcagg catatcaaca agcggccgat atctatgaag 557821 gtttaaaggt attggggata ttaaataagc aagagtatga ccacatggtg caagacaccg 557881 tttcgtttta tgaaaacagg ggagaacaat ttaagagaga tgaggcgata aggaatgctt 557941 cactttctgc gatgatgttt atgctgagtg ctaaggaaaa aggctgggat acctgcccga 558001 tgatcggctt tgatgcggaa gccgtaaaac ggattttgaa catagacgac caatttgagg 558061 ttgtcatgat gattacgatt ggaaaagaaa aaacagagag cagaagaccg cgcggctacc 558121 ggaagcctgt gaatgagttt gttgagtata tgtaaaagga gcggataaaa atggctaaaa 558181 aaacgatggg aattcatcat attacagcga ttgtcggtca ccctcaagag aacacagatt 558241 tttacgcagg agtgcttggg cttcgtttgg tcaagcaaac tgtcaatttt gatgacccag 558301 gtacgtatca tctttatttt gggaatgaag gcgggaagcc gggaacaatc attaccttct 558361 ttccgtgggc cggagcccgc caaggcgtca ttggagacgg tcaagttggc gtgacttcgt 558421 atgtcgtgcc gaaaggggct atggcatttt gggaaaagag actagaaaag ttcaacgttc 558481 cctacaccaa aatcgagcgc tttggggaac aatatgtaga atttgatgat cctcatggac 558541 tgcacttaga aatcgtggaa agagaagaag gagaggctaa tacgtggact ttcggagaag 558601 taacgcccga tgttgccatt aaaggttttg ggggtgcaac cctattatca gagcagcctg 558661 acaaaaccgc tgacctttta gaaaacatca tggggctgga gcgagtcggc aaagaaggag 558721 acttcgttcg ttatcgttcc gccggtgata tcggaaatgt gattgacctt aagttaacgc 558781 ctattggccg cgggcaaatg ggggccggaa cggtgcatca catcgcttgg cgggctaacg 558841 atgatgaaga tcagttagat tggcaaagat atattgcttc ccacggatat ggtgtaactc 558901 ctgttcggga tagaaactac tttaatgcca tttacttcag ggaacacggg gaaatcctgt 558961 ttgaaatcgc aactgatccc ccaggctttg cacatgatga aacacaggaa acaatgggcg 559021 aaaaactgat gctgcctgtg caatatgaac cgcatcgcac acaaattgaa caagggctgc 559081 tgccgtttga agtaagagag ttagattgat ttgacacata aaaaataaag aaacatatat 559141 tcaattgatg attgctggat ggtactgtca gcaaagaatc agataaaatc aaagatgagg 559201 agagatacaa atggaagatg caggactgtt gcttattcgt ataatgattg gtgtggtgtt 559261 tttgttttat ggcacacaaa aattattcgg ctggtttggc ggatacggga ttaaaggaac 559321 cggacaatgg ttcgaatcaa ttggggtgaa accaggaaac gttgcggccg ctctatcagg 559381 tcttggggag ttagtaagcg gaattctatt tattttaggc gtattcctcc cgcttggagc 559441 tgctatcata acaatcatca tgttaggtgc tatcgtaaaa gtccatggag cgaaaggttt 559501 tgcgaatggc gccggaggtt ttgaatataa cctggtgctc attgcagttt ccataggggt 559561 tgcactcatc ggttcaggag cttacgcttt gcatttttaa tacgaaagta tgtaagaaca 559621 gttgctgctt gtcagtaact gttcttttat tttcacattt tcggcaagct tgcaggtact 559681 ctgcaaagca aaaaagcgga tatcataaat ataaatctgt atagtgaatg atacgtattg 559741 atgagcttgg tcatgaaaaa cagacctatt tgaaggagta aatggatgaa agagatgaca 559801 ggattacatt cattagtttc tatagaaaac tttatcaaac agcacaaatt cagttttatt 559861 tatatatcaa ggcctggctg tacagtatgt cacgcagttc tgccccagct cagaatagta 559921 ttggatcagt ttccaaacat caaattgggg catatcaatg ctgacgatgt agcagaggtc 559981 gccggcagat tttcagtttt caccgttcct gtgcttcttt tgttcattga tgggactgag 560041 tttctaagag aagcccgttt tgttcatttt gaacagcttg aacaaaagct gaaaagggtt 560101 tatcgattat atgaaggcga ataaaggaat aaggcaaaaa aagaactcaa atgagttctt 560161 tttttattct tcactaggcg aagaagggtt atcaacctgc ccttgatcac ttgtatcatt 560221 atcacaactt gctgaaataa taattgaatg agaaggagag taatctccta atgtgaaatt 560281 cactccgtaa tttttgctgt tcgcagtatg gctgttttgc aagttttgtc cgatatctgt 560341 attggcgttt tgtgtcattc catttatcgt gagatttgag atgttgattt gagatcgcat 560401 gcttcaaaaa ctcctttcac tcagaagtag ctgtcataaa ggacgctggc agtctattta 560461 cttctatgat attgcgtttt tatatcattg catcaacata atggtaaaaa taatagcgag 560521 tgaatgatca tcttttgaag atgatcaacc tatcagcaga aataaagccg cctgataaag 560581 aggcggcaga tcgttatatg tcatctatga atttgatgta tcgtttttcg tttgcctgaa 560641 ggataagata gtcgttttta atgatgagta ggagcctata gcagcgtagc cataaaacca 560701 gcccataaat acgccagaaa agaggctgtg tcgatggctt atgaaaacag aaatgacaag 560761 gcctgttatt aaggcaactg acggtacaaa agttttgggg attttcaata atattttgag 560821 gatttgggtt atcaatatga tgattggaac agctatcaca gcatcccaaa agttcgtgtg 560881 aataattgga aaagccatac ggcacctcat gaagtgttta tttcttaatt tttacgctaa 560941 aagcttggaa agcagctctt ggatcgcata tgttacattt tgggcttgat tggcggagct 561001 tgtttggctt aaagcattgg attcaaaaac caaacctgta ttactcccac cggaaccctc 561061 tgttgtttta gacacagaga acgggctgat ggaaactgca aatccgttat taaaaacgct 561121 gttcccggat atcgaatgaa tataaactgg gaatttcatc attcatctct cctctctgtt 561181 atgactgttt atacaatatg gtgtgtgagc agcagttgct taaacaaaac ggcaaaaact 561241 ttcagtaaga gacaaaaacc tgcaaaatgc cacaagcgcc ttttgttaat gcagcttttt 561301 agggacgttt tttttatttt ttttgccaac ttcatcaaaa atattctgat tgccagactg 561361 ggcttgtccg tccttattta tgaaatcggg gtgaatgagt tttttcagat ccctgactgt 561421 taaaggcttg gcgtcatcag ttaattctat tcctaattgc ccgtttgcct ctaatgtcgc 561481 aattttgaca tcttgtatag ccgtaacgcc gtgaagcctt agctgcattt caagctggtc 561541 agctgtaagt ctcatcttct ttaagttttc gatatgaagc tgtccgtttt caatgacgat 561601 ttttgctttt ccggttaaca tcttttcaat ggtgttcgat ttcatttgga tccattccat 561661 aacgatgagt gtgcttgtga aaattgccgc tgcaattaat gttttgaaga ggctgtactc 561721 gatgattggc tgaacgataa tagttccgat cgaaatcatg acaaccgttt gagtcgacgt 561781 catttgtgcg attgatttcc ttcctgaaat tctcagcaaa atgaccccgg ctacaatgag 561841 aacaagagat tcccaagtga aattcatgct accacctgac caatgatgaa ttagatttgt 561901 catgggattg gcttttcttc cggccaatcg caatttaata tatccgaaag gcagtcggtt 561961 cattctgtcc tgaaccgaac aatatttttg gtatagatgg atatattaag ccaaacaatg 562021 atagcaacag gagttttttg gccgaaacaa tctgggaagc ggggagcgcc ataacatgat 562081 tgaacttgaa gttgtcatta gaacggttgc cagctttggc ttgctgttaa tcgcagaacg 562141 aattttaggc aaacagacaa tctctcaaat gacgattttt gattttattg cggcgatcac 562201 actaggggcg attgctgccg gattagctta caatacttca ataaaaccgc acaatatggc 562261 catttcgttt agtatttttg tgctaaccat ttttctaatt tcgtttctgt cgataaagaa 562321 caggaagctg aggaaatttt ttgccggaga tccaacagtg ctgattcaaa acgggaagat 562381 acttgaatca aatatgagga aaatgcgtta cacacttgat tatttaaatc agcaattacg 562441 ggaaaaagaa atatttaata tcgaagaagt tctttttgcc attcttgaaa cgaatggtca 562501 gctgactgtg ttaagaaaac cgcaattccg gcatgtgacc aaacaggatt taatgattgc 562561 ggtaaaccaa gaacaaaggc ttccgataga acttattatg gacggagaaa tcattgagaa 562621 taatttaaag cagaatcgtt tgacggaatc ctggcttttg gaagaattgc gaaaaagaga 562681 cataaaggtg aaagagaccg tgtacgcagt gctgctgggt aatggggata tttatgtgga 562741 tcaatataaa gaccatatat cagtccctat ggataaggaa tgaaggaaca atcaatctta 562801 aagcccctta ttgaacgcaa cggtttcaac ttgtcttggg tacgaaatat gcagaagccc 562861 gtttaacagc tgaatctgta acaaatgagt ttcagcggct tcgggaagct gaatgattcg 562921 ctcaatttct ccgtaatacc gttcacgcag cacttccatt tcggctggaa aaacaggcgt 562981 gatcgttcct ttgatcagca gctgggtttt agacagtaaa cggatcgtta attcttcctc 563041 atacacaccg ggcatttcca caatgataaa attatattcc tcatcttgat aaaagtcgta 563101 aacaaacgta gaagcttcgg aatcaaaaaa atgttccggg gctttatatt tgagcacatt 563161 tgtccaaaag tcactttgtt tatattcatt cgtaatctca agccactttc gaattttttc 563221 gaaatccata tgagattctc cttaaatttg atttgaaatc ggcgcagaag ggtttccgat 563281 ttggtcttgg tcactaacgt ctgaatcaat atttccagtg tttaaaagtg aagacgtagg 563341 cgaaagatcc cctaaggaaa agtttgctcc aaaatatttg ctgttcgcag tatggctgtt 563401 gtgcacagtc ggaccgacat ctatatttcc gttttgcgtg acgccgttga tcttaatatt 563461 tgcgatatta atttgatatg gcatagacga aaccccttta atctaaaatt ggcggtggtg 563521 caatcggagg agcattaacg ttggatgtat cagagttgcc gatagatgtc tggtcattta 563581 catcaggatc gtttaagaag ttttccatta cggattctgt aggtgatgta tcaccgaaag 563641 aagagttggt cccttgagat ttttgattgt tggtagggct gttataagca gcttcgccta 563701 ttgtaattga accattgccc gaaatactgt tgatcttcaa ataatatagg ttgattactg 563761 tagacggcat cccatcacac ccttccatct ttctgtacag tacattatgc gccgctgcac 563821 ccaattgttc cttgcattta cgggcaaaac tctatctggc cccggagtga tgctcaatta 563881 tcagtgaatg aaaagccatt gatataggaa tcaatgaatt gattcagtta ttcgaaatgc 563941 atgagacctt ttaataaagg aagctggcaa acaggatcag tttgaaataa ttgacaatga 564001 agctaatgcc atgaaataat actcgtgagt aacattactc gtgggtatta tttttggggt 564061 ggtcctagtt gaaaagtaaa ggagtagaaa gccgaaaacg attacttaaa gctgccgcta 564121 atgaattttc ggttcgggga ttccatgacg cgaaggtaag tgaaattgtg aaaaaagctg 564181 ggttcacgca gccttcattt tacctgtact ttcaaagcaa agaagccatc tttgccgagt 564241 taataaccga ttttcactct cgagtcagaa agctgacaga gtcacttctt ctggaaaacg 564301 gattaaacac ggaggatgtg tcaaaacggg tactgctagc tgtagagact gtttttcaat 564361 ttttggatga ggacaaggat ttaaccaaga tcggcttttt tctcaacccg gaagcaaaac 564421 aaatgaaaaa agacttggcg atggttttga aagagaactt agaagcagaa cagcggcttg 564481 gctattttca ctctgaactg gatatggaaa ctgtcgctga gtgtttggtc ggcatgattg 564541 aacatttaac cgaatcattt ttgttaaccg gaatcaaaga tccggcaagc ctcgcagcag 564601 aggttgtgaa tcttttaatt tacgggatgc ttccgaaagg gaatgatgta agatgatatc 564661 tattatgatg aaagtcagtt tggcagtttt tatgcttgcg ggaggcatca taaaggtaag 564721 ccgcgttccc tttcaagttg agcattggcg gcattatcaa tatccattat ggtttctgac 564781 tgttactggc attcttgaaa tagccggggc acttgctatg acagcgggaa tttggaatcg 564841 gtatgcagca attggagcag gtgttctgtt tgtcgttctc atggcgggag caattcatgc 564901 gcatatgttt cgagcaagac aatctgtcat catggcgata caagcgatga tttgtttgat 564961 tgtttcaatc atgatcatca tggggagtta cacgtaagct tttcactaat gtttaagaac 565021 aagcccattt gcaggaaatc tccttttctt atcgaataat agaaagtcca ggaattaact 565081 gaatcagtaa aatagagctc catttctgtg ttattcgtcc ggcatcagct gggctttttt 565141 tataaaggag gaatacagga tggcattcac tttggaagac atgactgagg aagagttcga 565201 agcctttcgc gggatgtccg tgcaaaattt tgcgaaacaa aacataacgt caggaacttg 565261 gacggaaaaa gaggcatttg agaaatcgga gcaggcatat gagaacatga ttccgaatgg 565321 gcgagacagc agcaatcatt atttttggaa catcacaaat gaccaaggag aaagaatggg 565381 ctggctctgg ctgtatgctg atccattaca tccgcaaaag gaagcgttta tctattcctt 565441 tggattgtat gaagcctttc gcggaaaagg acttgctcaa ttggcgcttc aaacgcttga 565501 tgaaagagca agagagcttg gtgcggaaag gctggctcta catgtatttg cacacaacga 565561 gacagccgtc tatctttatc agaagatggg ctatgccatg accaatatac gtatgcggaa 565621 acagctatgc tgaaaagccg cttacgttac ccaaatacaa catgcctatc tggaagcggt 565681 ggcagggtac tataagtcat cattagaaag attaaggtca tgggaggctt gaacatataa 565741 agaaaaagga caacagctgt tgtccttttc aatgccgctt gaactttctc cctcagtctt 565801 ttttgtcttg atgatccagc tcttttattc gtttcgtaag ctcattgaaa gcctgatcaa 565861 gctccttata ccctttatca tttggcgtca taaaactgag ctttcccagc acttcttgtc 565921 tttctgtctc aagctttaac cgaagctcct cccgctcatt tctttctgaa ggaacgtcgt 565981 ttaactgctt ttcgatgccg ttgtttgaga tgacgagttt actgtttgtt gttttttcga 566041 gaaagtatcg gtcatgtgaa accgccagca atgtgccgct gtattgtgac agtgtttctt 566101 ccagctgttc gcgtgacggc aggtcgagat ggtttgtcgg ctcatctaaa atcagcacgt 566161 ctttttcctc cagaatatat gccatcagct tgatctttac acgctcaccc atactcatat 566221 gcttgatcgg ttcagtccat tgggcggctg taaaacctaa gtgcctcatc agattttgaa 566281 cgtgccccct tgctttgaat gtttcattct caaataactc ttccggtgtt tgttctaaag 566341 gcaaatcaaa cacctcctgc gttaaatagc cgatgtttgc ggacggcgac acccatacac 566401 ttccttctgc tgtttcctgt cccagaatga tgttcagtaa tgtcgttttt ccgctgccat 566461 tggggcctat gatcgcaacc ttttcgccgt gctgaattgt aaagtttgcg tttttaaaga 566521 gagtcctttc tccaaacgct tttgttacat tctgaacttc taaaaaacgt tttcctgttt 566581 tgtgggttgt atcgattgaa aagcggactg tatattctgg ggtaacgggt tccgcctttg 566641 ctttttcaag ctctttttca agccgcttct gcttggattt tatctgggca tccgtacgct 566701 tcgcttttac ccggtgatat tctttaaacc cttccttttt cgtcgattga gcatgggctt 566761 tttccgacca agaagcgagc ccattcattt gtgcttcaat ccgttcaacc attttttgct 566821 gcttttcata ttcacgctgc tgggtgagtc ttttcttctc ccggaacttc atatacccgg 566881 agtaattccc tttgaattca atcagcgtct gatcctcaag cgaccatatt tttgttgcgg 566941 cttcgtctaa aaaatatcga tcgtgagaaa cgagaatcac agtgccgtta taatgtttca 567001 gctgttggat gagaaattgc aagctttttt catcaaggtg gtttgtcggt tcatctaaca 567061 gcagcagatc tgcatcctct gatagtcctt tcgccagccg cgctttcagt ttttcaccgc 567121 cgcttaactg atgaaaatca cgaagaggca catgccattt ctccagtaac ttcttttcgg 567181 caggtgtctg atccgcaaag gaatacgccg cggtttcctg ttcaaccaaa gccagtttta 567241 tatccttccg aaggatttga ccctgtgcag gggctaagtc attgtgaatg aggtgcagca 567301 acgtagattt cccagcgccg tttttgccga taatcccaat gatatctcct tgctgaacac 567361 tggcgtttac atgtttaaaa acagtttgat cctttacttc atagctaacg tttgttaatg 567421 ttacgatctc tttcatccat atccctcgct ttaaagggag aataaaaaaa tcctcccaaa 567481 tgtgttggaa ggattagccg tgcctgtgca tgatcaaata agctattttt tataaatagc 567541 agtgtcgtat atatagaaaa tgggcagact aatcctattt tttgatttga aatattgatt 567601 tcaaacggta aaaataagat tagttaatca ttgtccaccc atcatccctt cttgttttga 567661 ttacaaacac tatagcatac ctttaaattc aaaagcaaag gtcattttca tcaaaaaaac 567721 tcctgctctc atttttgagg caggagtttt gagtcttatt gatgcttcgc ttttctcact 567781 ttataaatca caatcagcaa aataaaccaa accggtgtga caaataagga aacacgagta 567841 tcctgtgcca gtgccagcac aaccagaaca aacgccagga acgcaagaat caggtaattt 567901 gtaaacggat aaagcggaag cttaaacttg tttgttttcg ctaattcagg tcttgttttg 567961 cggtatttca tatggcagat gaccgtaatc ccccaaatgt agataaagca tacggttgaa 568021 atacttgtga tcagggtgaa tacgccttct ggcatgatgt agtttaacgt aacaccgatt 568081 aaaatcacga tagctgaaaa gaataaagca tttctaggca ctttacgctg agtcagtttc 568141 gccattgact caggcgcatt gtgatctttc gccagggaat agaccatacg gcttgtactg 568201 aatacagcgc tgttgcatgc tgaagcagcg gatgtcaaca caacaaagtt gataatactt 568261 gcagccccga cgatgccaac agcgacaaat acttgtacga atgggctttc gctgggattg 568321 atgatatccc aaggatagat gctcataatc acgagaagag ccccgatata aaaaagcagc 568381 acacggacag gaatattgtt gatcgcctta gggattactt tttcagggtt ttctgtttca 568441 ccggccgtaa gcccgacaag ctcaatgccg acaaaagcaa acacaaccat ctggaacgag 568501 aggataaacc cgtgcatgcc attcgggaac aggcctccgt ggctccagag gtttgtgaag 568561 ctggacactc ctgagcttgt ggaaaagcct ttgaaaatca tcacaaggcc aatgacgatt 568621 aacgccaaaa tggcaatgac tttaatcaaa gcgaaccaaa attctaattc tccaaaaagc 568681 ttgactgtcg ccagattcat aatcagtaaa ataataagag cgattaagcc aggcacccat 568741 tgcggcacac ccgggagcca atattgagtg tagagcccga ctgctgtcag atcagccatc 568801 gcaatggaaa tccagcagaa ccaatatgtc cagccggtga taaaagctgc catatcgcct 568861 aggtagtctt gtacaaaatc cacaaaagag tgatagttca agtttgataa cagcagttca 568921 cccagcgatc tcataattaa aaagcaaatg atccctgtga tcatataagc aaataaaatc 568981 gaaggtccgg caaaatgaat cgatttgccc gagccgagaa ataagcctgt cccaatggct 569041 ccgccgatgg cgatgagctg gatatgcctg tttttcaagc ctctctgcaa cgtttgctga 569101 tttatattgt ctttcgtcat gtcgtctgtc actttatgtg ttcctccatt gaaaattgtt 569161 tattgagtca gcaatctatt tttaatgatt attataacac taaaatttct atctttttta 569221 ctaaaaaagg attgatgaaa agaattttaa tgtgatttgg actatttccc gaaaaaagcg 569281 gctccattta gggagccgct tttttatgct ttttcagttt ttgtcataaa caggtagagc 569341 ccgtaatctg tcggtgcgga tgcgtagcct gcctgccgca gcattgctgt gatattgccg 569401 cggtggtatg tcccgtgatt gacaacgtgg ggaagcagtt cggaaacagt tgttttcatg 569461 attccgcttg agggattttg aatctggagt ggcttattga gctgttcttt ttgctgtaaa 569521 aatagtatat agcgctcgga taacctcaga aaaaggtctt ccatttcctc tatttcttta 569581 gcctctgtct gttctttaag ctgttcagct aaagccaacg catcgctcaa ggttttgccg 569641 gaaaacactt caatccagcc gagatcagaa agataaacat gagacaatac atgggatatt 569701 gacggaaaca cgctttgaat ttcttgatgg tatatctctt ttggaagctc ttttaatcgg 569761 ttgaatattt gttgattggc ccagacgtta tattcataca atttgaatgc aaaatctgac 569821 atgttaaaat tccccctttc gtgtgtatag ctttcattat acacgaacat gagttcttat 569881 gtagagtgct cgaaaataaa atttgttgac atatatagtt tagaggaata aactaattga 569941 cattgaacat aaagtttagc ggggtaaact ataatgcgtc tgattagagc tcatttcata 570001 aattcttgtt ttttgcagca cacctgtcga ctcaagaagc aggttatcca gcaggtcagt 570061 aattaagttt ccgtggttat acacccacga cccgttccac ggattgcccc ctgcatcaac 570121 aggaagggaa ctttgcgctc caataatata atgatgagga ttagcatgtt taaccgcttc 570181 atcaagtggc gcttgatctg taccttgact gccgacacct tcaccgcctg attcatctaa 570241 taaagcattg attgtgtttt gaaccagttc aacgtgggca atctcctcta aaaaaatgcc 570301 gcgaagcaga tcgcggtact gtttctgctt tcctctgaaa ttagagcttt ggaaaaaaac 570361 tgcatcattg tacgcatttc tccgtaatga ccgcctaata tctcctgcag gaccttagca 570421 gctgccgggt ctggcttgtc cggtttaatg atattaatca gttcctcttt gtagtaatac 570481 ataacacgcc tcatttcttc ttaagagatt ttcttatatt atttgtaaga tgagataaaa 570541 tatatacatg ataagcatgg gaaggcgtga aagaagaaaa taaaaaaata caggaaaagt 570601 gttgaccaaa taaaacaggc atggtatatt attaaacgtc gctgatgaac agcgtgaaac 570661 aaaacagaaa aacaaaaaag ttttcctaag gtgtttacaa gattttaaaa atgtgtataa 570721 taagaaaagt cgaattgaaa aagattcgaa aaaacattaa aaaacttctt gacttcaaca 570781 tcaaatgata gtatgatagt taagtcgctc aataagcgcc cgtagctcaa ttggatagag 570841 cgtttgacta cggatcaaaa ggttaggggt tcgactcctc tcgggcgcgc catataagat 570901 accacgcggg tgtagtttag tggtaaaacc tcagccttcc aagctgatgt cgtgagttcg 570961 attctcatca cccgctccat tattgaatga tctttgaaaa ctaaacaaga caaaacgtac 571021 ctgttaattc agtttttgaa aatcgcacag cgatgtgcgt agtcagtcaa actagggcct 571081 gcacgatgca ggtcacacag gtgtcaccgc gggatgcggt ggacttaacc tgtgatccat 571141 ttatcggaga gtttgatcct ggctcaggac gaacgctggc ggcgtgccta atacatgcaa 571201 gtcgagcgaa cagatgggag cttgctccct gatgttagcg gcggacgggt gagtaacacg 571261 tgggtaacct gcctgtaaga ctgggataac tccgggaaac cggggctaat accggatggt 571321 tgtttgaacc gcatggttca aacataaaag gtggcttcgg ctaccactta cagatggacc 571381 cgcggcgcat tagctagttg gtgaggtaat ggctcaccaa ggcaacgatg cgtagccgac 571441 ctgagagggt gatcggccac actgggactg agacacggcc cagactccta cgggaggcag 571501 cagtagggaa tcttccgcaa tggacgaaag tctgacggag caacgccgcg tgagtgatga 571561 aggttttcgg atcgtaaagc tctgttgtta gggaagaaca agtaccgttc gaatagggcg 571621 gtaccttgac ggtacctaac cagaaagcca cggctaacta cgtgccagca gccgcggtaa 571681 tacgtaggtg gcaagcgttg tccggaatta ttgggcgtaa agggctcgca ggcggtttct 571741 taagtctgat gtgaaagccc ccggctcaac cggggagggt cattggaaac tgggaaactt 571801 gagtgcagaa gaggagagtg gaattccacg tgtagcggtg aaatgcgtag agatgtggag 571861 gaacaccagt ggcgaaggcg actctctggt ctgtaactga cgctgaggag cgaaagcgtg 571921 gggagcgaac aggattagat accctggtag tccacgccgt aaacgatgag tgctaagtgt 571981 tagggggttt ccgcccctta gtgctgcagc taacgcatta agcactccgc ctggggagta 572041 cggtcgcaag actgaaactc aaaggaattg acgggggccc gcacaagcgg tggagcatgt 572101 ggtttaattc gaagcaacgc gaagaacctt accaggtctt gacatcctct gacaatccta 572161 gagataggac gtccccttcg ggggcagagt gacaggtggt gcatggttgt cgtcagctcg 572221 tgtcgtgaga tgttgggtta agtcccgcaa cgagcgcaac ccttgatctt agttgccagc 572281 attcagttgg gcactctaag gtgactgccg gtgacaaacc ggaggaaggt ggggatgacg 572341 tcaaatcatc atgcccctta tgacctgggc tacacacgtg ctacaatgga cagaacaaag 572401 ggcagcgaaa ccgcgaggtt aagccaatcc cacaaatctg ttctcagttc ggatcgcagt 572461 ctgcaactcg actgcgtgaa gctggaatcg ctagtaatcg cggatcagca tgccgcggtg 572521 aatacgttcc cgggccttgt acacaccgcc cgtcacacca cgagagtttg taacacccga 572581 agtcggtgag gtaacctttt aggagccagc cgccgaaggt gggacagatg attggggtga 572641 agtcgtaaca aggtagccgt atcggaaggt gcggctggat cacctccttt ctaaggatat 572701 tatacggaat ataagacctt gggtcttata aacagaacgt tccctgtctt gtttagtttt 572761 gaaggatcat tccttcgaaa cgtgttcttt gaaaactaga taacagtaga catcacattc 572821 aattagtaat acaagatatc acatagtgat tctttttaac ggttaagtta gaaagggcgc 572881 acggtggatg ccttggcact aggagccgat gaaggacggg acgaacaccg atatgcttcg 572941 gggagctgta agcaagcttt gatccggaga tttccgaatg gggaaaccca ccactcgtaa 573001 tggagtggta tccatatctg aattcatagg atatgagaag gcagacccgg ggaactgaaa 573061 catctaagta cccggaggaa gagaaagcaa atgcgattcc ctgagtagcg gcgagcgaaa 573121 cgggattagc ccaaaccaag aggcttgcct cttggggttg taggacactc tgtacggagt 573181 tacaaaggaa cgaggtagat gaagaggtct ggaaaggccc gccataggag gtaacagccc 573241 tgtagtcaaa acttcgttct ctcctgagtg gatcctgagt acggcggaac acgtgaaatt 573301 ccgtcggaat ccgggaggac catctcccaa ggctaaatac tccctagtga ccgatagtga 573361 accagtaccg tgagggaaag gtgaaaagca ccccggaagg ggagtgaaag agatcctgaa 573421 accgtgtgcc tacaagtagt cagagcccgt taacgggtga tggcgtgcct tttgtagaat 573481 gaaccggcga gttacgatcc cgtgcaaggt taagcagaag atgcggagcc gcagcgaaag 573541 cgagtctgaa tagggcgcat gagtacgtgg tcgtagaccc gaaaccaggt gatctaccca 573601 tgtccagggt gaagttcagg taacactgaa tggaggcccg aacccacgca cgttgaaaag 573661 tgcggggatg aggtgtgggt aggggtgaaa tgccaatcga acctggagat agctggttct 573721 ctccgaaata gctttagggc tagcctcaag gtaagagtct tggaggtaga gcactgattg 573781 gactaggggc ccctaccggg ttaccgaatt cagtcaaact ccgaatgcca atgacttatc 573841 cttgggagtc agactgcgag tgataagatc cgtagtcgaa agggaaacag cccagaccgc 573901 cagctaaggt cccaaagtat acgttaagtg gaaaaggatg tggagttgct tagacaacca 573961 ggatgttggc ttagaagcag ccaccattta aagagtgcgt aatagctcac tggtcgagtg 574021 actctgcgcc gaaaatgtac cggggctaaa cgtatcaccg aagctgcgga ctgttcttcg 574081 aacagtggta ggagagcgtt ctaagggctg tgaagccaga ccggaaggac tggtggagcg 574141 cttagaagtg agaatgccgg tatgagtagc gaaagagggg tgagaatccc ctccaccgaa 574201 tgcctaaggt ttcctgagga aggctcgtcc gctcagggtt agtcgggacc taagccgagg 574261 ccgaaaggcg taggcgatgg acaacaggtt gatattcctg taccacctcc tcaccatttg 574321 agcaatgggg ggacgcagga ggatagggta agcgcggtat tggatatccg cgtccaagca 574381 gttaggctgg gaaataggca aatccgtttc ccataaggct gagctgtgat ggcgagcgaa 574441 atatagtagc gaagttcctg attccacact gccaagaaaa gcctctagcg aggtgagagg 574501 tgcccgtacc gcaaaccgac acaggtaggc gaggagagaa tcctaaggtg atcgagagaa 574561 ctctcgttaa ggaactcggc aaaatgaccc cgtaacttcg ggagaagggg tgctctgtta 574621 gggtgcaagc ccgagagagc cgcagtgaat aggcccaggc gactgtttag caaaaacaca 574681 ggtctctgcg aagccgtaag gcgaagtata ggggctgacg cctgcccggt gctggaaggt 574741 taagaggagc gcttagcgta agcgaaggtg cgaattgaag ccccagtaaa cggcggccgt 574801 aactataacg gtcctaaggt agcgaaattc cttgtcgggt aagttccgac ccgcacgaaa 574861 ggcgcaacga tctgggcact gtctcaacga gagactcggt gaaattatag tacctgtgaa 574921 gatgcaggtt acccgcgaca ggacggaaag accccgtgga gctttactgc agcctgatat 574981 tgaatgttgg tacagcttgt acaggatagg taggagcctt ggaaaccgga gcgccagctt 575041 cggtggaggc atcggtggga tactaccctg gctgtattga ccttctaacc cgccgccctt 575101 atcgggcggg gagacagtgt caggtgggca gtttgactgg ggcggtcgcc tcctaaaagg 575161 taacggaggc gcccaaaggt tccctcagaa tggttggaaa tcattcgcag agtgtaaagg 575221 cacaagggag cttgactgcg agacctacaa gtcgagcagg gacgaaagtc gggcttagtg 575281 atccggtggt tccgcatgga agggccatcg ctcaacggat aaaagctacc ccggggataa 575341 caggcttatc tcccccaaga gtccacatcg acggggaggt ttggcacctc gatgtcggct 575401 catcgcatcc tggggctgta gtcggtccca agggttgggc tgttcgccca ttaaagcggt 575461 acgcgagctg ggttcagaac gtcgtgagac agttcggtcc ctatccgtcg cgggcgcagg 575521 aaatttgaga ggagctgtcc ttagtacgag aggaccggga tggacgcacc gctggtgtac 575581 cagttgttct gccaagggca tcgctgggta gctatgtgcg gacgggataa gtgctgaaag 575641 catctaagca tgaagccccc ctcaagatga gatttcccat tccgcaagga agtaagatcc 575701 ctgaaagatg atcaggttga taggtctgag gtggaagtgt ggcgacacat ggagctgaca 575761 gatactaatc gatcgaggac ttaaccatat ttttgaatga tgtcacacct gttatctagt 575821 tttgagagaa cactctcaat ttgtttggtg gcgatagcga agaggtcaca cccgttccca 575881 taccgaacac ggaagttaag ctcttcagcg ccgatggtag tcgggggttt ccccctgtga 575941 gagtaggacg ccgccaagca ttacttttat catcgcgggg tggagcagtt cggtagctcg 576001 tcgggctcat aacccgaagg tcgcaggttc aaatcctgcc cccgcaacca aatatatggt 576061 taaataagga gtgccctaag ggtgcaacca aaataatcct atacaaatat ggtccggtag 576121 ttcagttggt tagaatgcct gcctgtcacg caggaggtcg cgggttcgag tcccgtccgg 576181 accgccatta atgtaaacga aacgatcatg ttttcgtttt ttttgtgttt tcttttactg 576241 tatcttctgc ttggtgtcat agccaagctt tctttatatc gggaacatct tggatattcc 576301 agcaaaattc gataaactag gaagagcaca aataggcata agcagggttg aaaggaggtt 576361 ttggttcatg gatgaatttg atttgataca tagcattact ccgcggacca ttcaccattc 576421 ttccgttgat gtaggaatag gtgatgatgc agcgctctac actgcgaaac acggcgttca 576481 ggaaattgtt tgtgttgata ctatggtaga agacgtgcac ttcaaattac actattcctc 576541 acctgaagat atcgggtaca aggcgttagc cgttaatata agtgatattg ccgcgatggg 576601 aggcattcct aagttttatc tggtatcact tgcggtacct tcaaaatgga ctgaatctga 576661 aatcaaggcg atgtatgaag gaatgaatga actggcgaaa ctatatcata tggatctgat 576721 tggcggcgat acagtttcta ccgctgacaa attagtcgtt acagtcactg taatcggtga 576781 aattgaaaag ggacaggcct gtttgcgcag cttggcaaaa ccgaatgata ttgtgtttgt 576841 aaccggtgaa atcggttctt ctgcagcagg gctttcttta ttgctggaag agactaatcc 576901 tcaaaactca tctgtggaaa cggattactt tatccacagg cataaacggc ctgagccaag 576961 agtaagcgtc ggcagattat gctcgatttt taaacgggca gctttaaatg atgttagtga 577021 cggattggct agtgaactga acgagattgc agaagccagc tgtgtttcaa ttgaaattgt 577081 tgaaagcatg cttccaattc attctgattt gcctaagctt catcctaact ggaaagaatg 577141 ggctttgttt ggcggtgagg attttgagct gacagggacg gtttcaaatg aggagtggga 577201 agtgttgaag caggagtgcg cagcgcttca tcttcccatt acaaagattg gctatgtcag 577261 ggaaaaaaca aaatctaaag tgatcctaaa aacagatcaa acatcaatga tcttagagaa 577321 aaagggatat aatcatttta aataagacgg gtgactcgtg tgaagcaatt aaaatggaga 577381 actgtaaatc cagaagaaac aaaagcaatt gccaagctga cggcagcgtt tgctaaaccg 577441 ggagacgtcc tgacattaga gggcgattta ggtgcaggaa aaacgacttt tacgaaaggt 577501 tttgcagaag ggctgggaat tacacgtatt gtaaacagtc cgacttttac aattataaaa 577561 gaatataacg atggcgtact tcctctttat cacatggatg tgtatagaat ggaagatgaa 577621 agtgaagatt tgggacttga tgaatatttt cacggacaag gtgtctgtct cgttgaatgg 577681 gctcatttaa ttgaagaaca gctgccacag gagcgactgc aaattgtcat caaaagagct 577741 ggtgatgatg agcgggaaat tacctttact gctgtcggga atcggtatga aatgctttgt 577801 gaggagttaa gtagacatga caatattagc aattgataca tcaaattata cattgggcat 577861 tgcgctgctt cgagaagaca ctgttatagc agaatacatt acatatttga aaaagaacca 577921 ctctgtaaga gcgatgcctg ctgttcattc attgctgaat gattgtgata tggcaccgca 577981 ggacctttct aaaattgtcg ttgcaaaagg ccctggttca tacacaggag taagaatagg 578041 tgtgacgttg gccaaaacac ttgcctggtc tttagacatt ccaataagtg ctgtatcaag 578101 tcttgagacg cttgcggcaa atggccggca ttttgacggt ctgatcagcc caatctttga 578161 tgctagacgg ggacaggtgt acacaggtct gtatcaatat aaaaatgggc ttttagagca 578221 agttgttcca gatcaaaatg tgatgctggc agattggctg gagatgctaa aagaaaagga 578281 ccgccctgtt ttgtttttag gccatgatac ttctcttcac aagcagatga tcgaggatgt 578341 gcttggaaca aaaggattca ttggaactgc cgcccagcat aacccgcgcc cttcagaatt 578401 ggcttttctc gggaaggaaa aggaagcagc tgatgttcat gggcttgtcc cggattactt 578461 gcggctggca gaagctgaag cgaaatggat tgaaagtcaa aagtagggtg ataggatgaa 578521 aacaaaagca gcggtcagaa atatgcggct tgaagatata gatcacgtat acgaaatcga 578581 agcatcctcc tttacgtctc cttggacgaa ggattcgttt tatcatgagc tgctggaaaa 578641 tccgtatgct cattatctcg tgattgaaaa ggacggccat cttgctgggt attgcgggat 578701 ttggattgtg atggacgatg cccagattac aaatatagcg ataaaaccag agtatcgcgg 578761 ccagtcttta ggagaaacgc tttttcgctc agctgttgaa ctgtgcaaag aaaaagacgc 578821 aaggcggctt tcgcttgaag tgagggtttc gaatcatcct gctcaaggct tatataagaa 578881 attcgggatg cagcccggcg gaataagaaa gaactattat actgataacg gggaagatgc 578941 gttaattatg tgggtgacga taaatgagtg agcaaaaaga catgtacgta ttaggaattg 579001 aaacaagctg tgatgagact gctgcagcta ttgtgaaaaa cgggaaagag atcatttcaa 579061 acgtagtagc ctctcaaatt gaaagccata agcgcttcgg aggcgttgtt ccggaaattg 579121 cttcaagaca tcatgttgaa caaatcactt tggttataga agaggcgttt cgcaaagctg 579181 gcatgacgta tagtgatatt gatgcgattg cagtaacaga aggtccggga ctggtgggag 579241 cgcttcttat cggagtgaat gccgctaaag cattgagctt tgcatataac attccgttag 579301 taggcgttca tcatatagcc ggtcatatat acgcgaaccg tcttgtagaa gacatcgtgt 579361 tcccggcact ggcattggtc gtttcaggag gccatacaga actggtttat atgaaggaac 579421 atggatcatt tgaagtcatt ggggaaaccc ttgatgatgc ggcaggagaa gcctacgaca 579481 aagtggcgcg gacgatggga ttgccatatc cgggtggacc gcaaattgac aagctagctg 579541 aaaaagggaa tgacaatatt ccgcttcctc gcgcatggct tgaagaaggc tcttacaact 579601 tcagctttag cggattgaag tctgcggtga tcaatacgct tcataatgca tcccaaaaag 579661 ggcaagagat tgctccggaa gatttgtctg ccagtttcca aaatagtgtg atcgatgtct 579721 tggtaaccaa aacggcgcgc gcggcaaagg aatatgatgt caaacaggtc cttttagccg 579781 gaggagtagc tgcaaacaga ggcctcagag ctgcattaga aaaggaattt gcccagcatg 579841 aagggattac gcttgtcatt cctccattag ctttatgcac ggataatgct gcgatgattg 579901 ctgctgctgg tacaattgct tttgaaaaag gaattcgcgg tgcatatgat atgaatggcc 579961 agcccggcct tgaattgact tcttatcaaa gtctcacgag ataatagcgt gagacttttt 580021 atctgtttgt tattaacaga caattcacaa tttatccaca tatctgtgag taattataga 580081 gatattgatg gataaagggc tgaggtcact gttaataaag tggataaatt cagaatattt 580141 tgtggatagt gtgtataaag cgcttacttt gtttatttat taggggatgt tctgtggata 580201 aaaagcacct ctaaaaagag gtgcttgact tttttaatct tcttctgtgg atagttcttc 580261 ccattcggac aaaagagatt ccagctcctg attaagcttc tcattgtctg catggatagc 580321 ttgtactttt tcatgatcct gatagacttc agggtcacat agcaattcat cattgcggct 580381 gatgttctcc tcaatggttt gaacggtggt ttcaatttct tcaatccgac ggagtcgttg 580441 gcgctctttc tttttccatt ctttttcttc ctcgtaggaa cgtttggagt cagacttcac 580501 tgtagctggc gttttatcag tttcctcttg ctgattcatt ttctccaatt caagctgctc 580561 tgtttttttc tctgtataat aatcgtaatc tcccagatac tcctctatat ggcttgaaga 580621 aagctccaat actcttgtgg cgattctgtt aataaaatat ctgtcatgtg agacaaataa 580681 cagtgtgcct ggataatcaa tcagcgcgtt ttcgagaact tctttgctgt ctaaatccag 580741 atggttcgtc ggttcatcaa ggatgagaaa gttggctttt tgaagcatca gcttagctag 580801 agccaatctt gctttttcgc ctccgctcag tgaatgaact ggtttcagca catcatctcc 580861 ggagaataag aaatttccga gacacgttct gatttctttt tctgggagcc cggggtactc 580921 gtcccacagc tcatcaagga cacgtttaga ggaagtcaac tcagcctgtt cctggtcata 580981 atagccgaca ctgacatttg agccgtaaga aattgttccc tgatctggtt ttagggtgtc 581041 tattaatgtt ttcagcaatg tcgatttacc tattccgtta gggccgacaa gcgcagcgct 581101 ttctcctctt gtgagcatga atgacacttc tgttaaaagc ggcggctggt tttcatagct 581161 gattgtgaga tcctgaacac gaaggacttc atttccgctc tgttttgtaa tatcaaaatg 581221 aaagtttgcg gatttttcat cgccaagcgg ttttgacatg acatccattc gctcaagctg 581281 ctttctgcgg ctttgcgccc ttttggtggt agaggctctc gccagatttc gatctacgaa 581341 gtcctgcagc tttgcaatct cgtcctgctg cttttcatac attttcagat ctttttcata 581401 ctgcgcggct ttttggtcga gataagcgct gtagttgccg tgatactttt tgctttctgc 581461 tcttgatacc tcgtatacct ggtttactac tttgtccaaa aagtagcggt catgcgaaac 581521 gatgagaatg gcgcctgaat agccttgtaa ataatgctca agccaggtaa gcgtatcaat 581581 atccagatgg tttgtcggct catcaagaat gagcaaatca ggctgtgtta atagaagctt 581641 acctaaagcc agtcttgttt tctggcctcc gctgaggctt tgaacctgtg tagaatcgtc 581701 aaaatggctg aagccgagac catgcagcac agatctaaca tccgcttcat attgataacc 581761 gcctttatct ttgaattcct gctgaagacg gtcgtaggtt ttcatgatgc tttctaattc 581821 acccgggtca gctgccgcca ttttttcttc catagcccgc atttcctttt ccattgcttt 581881 taagtggtca aaaacagtca gcagctcttc ttttatggta agcttagaat ccaagccagt 581941 atgctgggcg agatatccca ttgtaatatc tttcggttta ataatttcgc ccttttcata 582001 cgaaagctgg cctgcgataa ttttaaggag cgtggatttt ccggcgccat ttcttcctac 582061 aatggcgatg cgatcacgat ttctgacttc cagctttata ttgtttaaaa tagtatcagc 582121 accaaatgat ttggacagct gattaacttg taagatcatc atattatttc acctctgcta 582181 taataagtta agtgtagctt atgaaccaga agtcagcaaa caatacattg gccatataag 582241 acatagagaa gaaaatagtg tatgatctgt ttaaggagcg ttttaatatg aatggatttt 582301 ctcattttaa tgaacagggc agagcccaga tggtggatat tagcgaaaaa tcttcgactg 582361 tccgtactgc ggcggctgtt tcaagcgtac acatgaagaa tgaagtgtac gagaaaatac 582421 aaagtcacga tatcggcaaa ggagatgtac tggctgtcgc acaggtggca ggcattatgg 582481 ccgcaaagca aacgtcgaat atcattccga tgtgccatcc gctttcattg agcggggtag 582541 atatatcgtt tgactggaaa ataaaagaag cagaagttat acttcatata aaagcacagg 582601 tcaaaacgaa agggagtaca ggtgtggaaa tggaagcgct cacttctgca tcggtgtgcg 582661 ctcttaccgt ttacgatatg tgcaaggccc ttgataaggg aatggtcatc ggccctactt 582721 tcttgctgga gaagacaggc gggaaaaacg gtgactttaa aagagaacta tccgagtata 582781 atttggagga ccaaaaatga ataaggatca atcaaaaatt ccgcaggcga cggcgaaacg 582841 gctgccgctt tactatcgct ttttaaagaa tctgcatgcg tcaggaaaac agcgtgtatc 582901 atccgctgaa ctcagtgatg ccgtaaaggt tgattctgcc acgattcgga gggatttttc 582961 ctattttgga gctcttggca aaaaaggata cggatataat gtggattatt tgctgtcttt 583021 tttccggaaa acgcttgatc aggatgagat gacagacgtc atcttgattg gtgtcgggaa 583081 cttgggaacg gcatttcttc actataattt cacaaaaaac aataacacaa aaatttctat 583141 ggcttttgat ataaatgaga gtaaaatagg aactgaggta ggcggcgtgc ccgtctataa 583201 ccttgatgac cttgaacaac acgtaaaaga tgaatcagtt gccattctta cagtgccagc 583261 agttgccgct caatccatta cagacagatt ggtcgcatta ggaatcaagg gaatccttaa 583321 ttttacgccg gcccgtttga atgtgccgga acacattcga attcatcata tagatttagc 583381 agttgagctt cagtcactgg tttatttttt gaagcattat tcagttttag aggaaatcga 583441 atagagggaa aggaggagcc caaatatgcc gatcggtcct ggaagccttg ctgttatcgc 583501 aatcgttgct ctgattatct tcggtcccaa aaagctgcct gaattgggga aagcagcggg 583561 agacacactt cgtgaattta aaaacgctac taaaggatta acgagtgatg aagaggaaaa 583621 aaagaaagaa gatcagtaag ttaggatgac acgaatgaaa gtgaatcaaa tgtcgctgct 583681 ggagcatatt gctgagcttc gaaaacggtt gctgattgta gcgctggcgt ttgtcgtttt 583741 ctttattgct ggattttttt tagcaaagcc gattattgtg tatctgcaag aaacagatga 583801 agcgaagcag cttacgctta acgcgtttaa cctgacagac ccgctttatg tgtttatgca 583861 atttgcgttt atcatcggca tagtcttgac ctcgccggtt attctttatc agctttgggc 583921 ttttgtgagc ccgggcctct atgagaaaga gcgcaaagta acgctcagct acattccggt 583981 ctctattttg ctgtttttag cgggcttatc tttttcatat tatattttat ttccttttgt 584041 tgttgatttt atgaagcgga tttctcagga cttgaatgtc aatcaggtga tcggaattaa 584101 tgaatatttt cattttcttc tgcagctgac gattccgttt ggactgctgt tccaaatgcc 584161 ggtcatcctc atgtttttga caaggctcgg aattgtgaca ccgatgttct tggcgaaaat 584221 cagaaagtat gcgtatttta cgctgctggt gatcgcagcc ctgattacac cgcctgagct 584281 tctgtcccat atgatggtca cagtcccgct tttgatttta tatgaaatca gtatccttat 584341 atcgaaggcc gcttatcgga aagcacagaa aagcagtgct gccgatcggg acgtgtcttc 584401 tgggcaataa taaaaaatcc atttctcatg cgagaaatgg attttcttta tttttggttc 584461 tttttgattt taaatgaaaa ggcgaacatc ttaaaagaaa tgctgatgtt gtaagcggcg 584521 aacaccatca gcaggatgga gtaaaatgac cacatgctgc ctggcgagct tgcggcaaga 584581 taagtaaaga tgcaccctac ggcaaagtag atcattcccc aaactaccgg gtttctcata 584641 aaaataatcc tccaataatc aattgcattt gtgtgctctg ctgttcaagg taattacgaa 584701 caggctcaag ctgcatgatg acgacgaatg tattcatcat taaatgggcg aaaatcggca 584761 cccatatccg ttttgttctc gcatataaaa aggcaaaggt aaagcccatt gctgtatata 584821 gaaggagatg cttcaaatca gcgtgaacaa taccgaagat aaccgagctg atcagtcctg 584881 cgaaaaagaa attcgttttt tcgtacagcg cgccgaaaat gatttttctg aagatgattt 584941 cttctaatat aggcccgacg atggaagaaa cgataatcat gagcgggact gcctgaatga 585001 catccagaat cgcttgtgta ttttctgatt ctcttccgat gccaaaaaca taatattcaa 585061 tagagcctgc tattccttga gagaaaaggg caatgaaaaa accggctatc gcccaaagga 585121 tagaaagtcc gattgagtcc ttctgtccgt ttcgcagcgt ttctttcgga acggttctca 585181 gaatgagcag aacaacaacg agacaggcga taaagctgat aacggaccat aatccttgtg 585241 catgcagcat attttcatct gtaggctgtc ctccggcata accgaattta aataacaagg 585301 gaatcgcgat taatgcggaa aactgcatga tgatatatgt caaaataata aaccaatact 585361 gttttctcaa atggtatgta ctcctttgtt aagtgggttt cgttcatcta cagctattgt 585421 aacataatcg gtacgggggt gaaaaagcta acggaaaagg gagcggaaaa gaatgatgta 585481 agcgtgaaaa attttttatc ttatcacttg aaattggaag ggagattctt tattataaga 585541 attgtgttag cactctttag tgctgagtgc taaaattaca tattcatact attgaggagg 585601 ttatttcatt gttaaagcca ttaggtgatc gcgttgtcat tgaactcgta gaatctgaag 585661 aaaaaactgc cagcggaatt gtgttgccgg attctgcaaa agaaaaaccg caagaaggca 585721 aaatcgtggc agctggttca ggtcgcgtgt tagaaagcgg agagcgcgtt gctttagaag 585781 taaaagaggg cgaccgcatt atcttctcaa aatacgcagg tactgaagtg aaatacgaag 585841 gtactgaata cttaatctta cgtgaaagcg acattttagc tgttatcggc taattcttaa 585901 ataaacaata cttaaaacat ttgaggaggt cttgtaaaca tggcaaaaga aattaagttt 585961 agtgaagaag ctcgccgcgc aatgcttcgc ggtgtcgatg cacttgctga tgctgttaaa 586021 gtaactttag gaccaaaagg acgcaacgtg gttctagaga aaaaattcgg ttctccgtta 586081 atcacaaatg acggtgtaac aatcgctaaa gaaatcgagc tagaagacgc gtttgaaaac 586141 atgggtgcta agcttgttgc tgaagtagcc agcaaaacaa acgacgttgc cggtgacggt 586201 acaacaactg caacagttct tgcgcaagca atgatccgtg aaggccttaa aaacgtaaca 586261 gcaggcgcta accctgtagg cgtgcgtaaa gggatggaac aagctgtagc ggttgcgatc 586321 gaaaacttaa aagaaatttc taagccaatc gaaggcaaag agtctatcgc tcaggttgct 586381 gcgatctctg ctgctgatga ggaagtcgga agccttatcg ctgaagcaat ggagcgcgta 586441 ggaaacgacg gcgttatcac aatcgaagag tctaaaggct tcacaactga gcttgaagtt 586501 gttgaaggta tgcaattcga ccgcggatat gcgtctcctt acatggtaac tgactctgat 586561 aagatggaag cggttcttga caatccttac atcttaatca cagacaaaaa aatcacaaac 586621 attcaagaaa tccttcctgt gcttgagcag gttgttcagc aaggcaaacc attgcttctg 586681 atcgctgagg atgttgaagg cgaagcactt gctacacttg ttgtgaacaa acttcgcggc 586741 acattcaacg cagtggctgt taaagctcct ggtttcggtg atcgccgtaa agcaatgctt 586801 gaagacatcg ctgtccttac tggcggagaa gtcatcacag aagatcttgg ccttgacctg 586861 aaatctactc aaatcgctca attgggacgc gcttctaaag ttgtcgttac taaagaaaac 586921 acaacaatcg ttgaaggcgc tggcgaaaca gacaaaattt ctgcccgtgt gactcaaatc 586981 cgcgctcaag tggaagaaac aacttctgaa ttcgacagag aaaaattaca agagcgtctt 587041 gctaaacttg ctggcggcgt agctgtcatc aaagtcggcg ctgcgactga aactgagctg 587101 aaagagcgta aacttcgcat cgaagacgcc ttgaactcaa ctcgcgcagc tgttgaagaa 587161 ggcatcgtat ccggtggtgg tacagcgctt gtaaacgtat ataacaaagt cgctgcagtt 587221 gaagctgaag gcgatgctca aacaggtatc aacatcgtgc ttcgcgcgct tgaagagcca 587281 atccgtcaaa tcgcacacaa cgctggcctt gaaggatctg tcatcgttga gcgcctcaaa 587341 aacgaagaaa tcggcgtagg cttcaacgct gcaactggcg aatgggtaaa catgatcgaa 587401 aaaggtatcg ttgacccaac aaaagttaca cgctcagctc ttcaaaacgc tgcgtctgta 587461 gctgcaatgt tcttaacaac agaagctgtt gtcgctgaca agccagaaga aaacggtggc 587521 ggcgcaggaa tgcctgatat gggcggcatg ggcggtatgg gtggaatgat gtaataaagg 587581 gatattaacc cttatacatc aatgttttaa ccgtcttaaa aaactagaca aagcgtgaat 587641 aaaaaaagag aaggtctttc atcagtttac taaactgttg ggagaccttt tctccatatt 587701 agcggtcata tgagcataaa tgtccatcgt cgtatttatg tccgaatgac caaattgttg 587761 ctggatttct ttaatgccta ctcctgcctc aattagtaag gaggtatggg tatgcctaaa 587821 agagtggggg gtgacattct ttttatccca gcttttttga gcagccgttt aagtctagtc 587881 tcaataacct ttcttaattg cggatgacca tcctcccgct caaaaataaa tgatgagtct 587941 tgataaatca atctattttt aagcttaatt tcattttgat aaattttatt tttttttagt 588001 agattgacat cgtttcatca attcgaacga tatcaacaga tcctgttgtt ttaggtgtta 588061 gcaattggta tttttcaatt tgattgttag gggtgtatag ggtctttgtg acctggctta 588121 tcattgaaat ctgtccattt taaagcaaga agttcaccaa ttcttaggtc ggtctaggca 588181 agtacggtaa agaccaaatg gtccatttct agcccgtcag attgagcgag ctttagaaaa 588241 tgtgtcagca cctctttttc caatgctttg ttgcttcttg ggtaattgaa aatccccagt 588301 tgggttcatt ttaataatcc cttgagtttt agcttttcgg aaaatcatac ggccgcaggc 588361 atgaatacct cccaaacaat tgtgactgta ttgctcgttc agttctaacg tgcggtcttc 588421 atacattttt ttgtgttttg ctaatcgggt attgacccaa tactgcgata aaatgcatca 588481 ttttcttttc actggcccgt acactgctta tttttacccc actccggttg taaatcttaa 588541 gccaaccttt tgcaaatgtt ttgaagggca tatctgactc cttaataaaa gtcccgttgt 588601 cgttttggag ttctacgtga cgggctgcta ctggggcttc tttctttgtt ttaaatcttc 588661 ctttggatat ttctagacgt tttttggtta aagggtcaat gcctagtaga tatgataact 588721 ccacgtctta ccgcattgct tgagttttgc catttatttg tccctaacta attttttttc 588781 atcaaattgg tctttaagtg agtttaataa tttttgtttc tctcgactgg tcaataattg 588841 cccttcatat ttcaaaagat tggataaatt tgagatggaa tcaatcctga tggatggtac 588901 cgtagacttt aataagaaac gaaaggccaa ctgcgacttc agttggcctt tcctatttat 588961 aataaagaaa ttgagtgaga ttgctgacag aactacgtac tactcgtttt ctttagttgc 589021 ccttgctaat cgttcaacct ctccccgaat cccaatcgca ggctcccacg aatcaatcaa 589081 acgaatcgcc ttctgattag attccaccgc tttcgttttc tctcctttac gatacaacag 589141 ctgcgccatt ccgtagtgat agtagatcag ttcaacttga ttggcgttat gtttgtcata 589201 gagcatttgc tcaaaggctt cttccgcttt ttcaaactga tcacatttca cgtaagcgac 589261 acccagattg aaataggctt ctatcgtttt ttcgccgccg tatgtggagc tgatttcatt 589321 tgccgcttcg tataattgaa tggcttctac atgataacct ctcgcaaagc ttaagtcacc 589381 gcgaaccaat agaactctgt gttgaatggt aggggaaatc ggttgatttt cgatttcgtt 589441 taaaattgtc tctgcttttt cctgttgccc gtcttttaaa aacagccttg ctttgagtgc 589501 atgtccccaa acctttagat cataggcatc gtgagcgtct gattgttcaa gaatcttcag 589561 cccggcttct atttgctgaa gcgctccgtc taaatcattg acttccatca atgcccagcc 589621 tgaggtgtcg attcggaagt acgcttctcg tgtgtgttgg cctaagtgat gggcggcgtc 589681 ggccgctttg cgtccgtatt cgattcgcag gggcaggttg attctgctta gaaaatggct 589741 aatgcgggtg atgagttcga ttaggatttc tttttgttca gtttcacttg cccattggat 589801 gacctttaag atgtttggcc attcttgttt catttgatct aagttccgtc ccagcaggta 589861 gctccaatag atagagttgg gctgttcccg ctttaaatgg gtttcggcat aatcaatata 589921 atagtgcgcc cagcgattgc gggcttcttt ttcatattcg tgctgttcgg acaagtgctg 589981 ttctccgtaa gcgacaacgg tttggtgcgc taagtattgt gtcctgcctt ggcttcgttc 590041 cggctgaatc agcgcatatg accgcatttg ttccatagcg taatgaaaac ggcgggcgtc 590101 taatccggct gctgccgcca ggcttttttc atcaggcggc ttgctgaaaa agcaaagcgt 590161 ctgccagagc tttcgcgtat cttcattgca tctatcccag gtgcggccaa agaggaattc 590221 aaacaattcc agcagtgagt agcctgcttt tccaagctca tgaatcagct gctgagcggg 590281 gatgtcatcg tctgacatat aggcaatgct gagtgccatg gctttcgggt ttccggcagt 590341 cgctgaaatg aattcgtttt tcaggtcaga tgatagatgt aacagctgct ccagcttttc 590401 ccgtttacgt gggaggttgc atgtttgtaa gcagtgatgc acttcttgtt gaaaaaattc 590461 gtgggcatct gtttggtcaa gaccgcttag ctgaatggct gtcatttctc cgaagctttc 590521 ccgataagtt tgctttacgt tttcccgcgc tgtaaggaga acttttacgc cttgcggaag 590581 gctggtgata aattcatgaa tgtcacgttc tgcagtatca atgctgtcaa cgatcagcag 590641 gatcggtttt tctctagtgt aattggctaa cgcattgcgg acgacaaacc gttttacatt 590701 gattgattta tcgatttgtt ctttgcgtcc gagctgatag gcgatcgtat ttaaaaaatc 590761 gctaaagctt aatcctttcc aatcagcgct gacccagatg atgctgttga atgccggcca 590821 aactgaagta tcgtcgacac aggaataggc ggcttcaaga gcaattgtgg tttttcccat 590881 gccggcccag ccggtgatta aacagactgg tgatggagaa agcatccatt gccgtatcgc 590941 ttccatatca aagctgcgtc cgataaagcg tccggaccag cgtgagggta aattatgcgt 591001 gatgggctgt tctgtaagcg cattcgtttc ttggccgggt ctgtcatgaa acagccgttt 591061 tactacattt tcaatttcgc cttcactcgg agccccgaat aatccgtctt ttcgcagtat 591121 tttcgctttt ttcaaacagg atgctgccca tacaggcaat gcgggtttga tgactgggat 591181 agtggtggct tccagcaagt cggtcaacca ctcgatatcc aagtcggtct tttcgagaat 591241 gatccagatc attccgaaca gttttccgtc gtcgattctt ccgggaatgt agtttgcccc 591301 catctgtccg atccagcttt tgatcgtgtt tggggagact cccagctgga gtgcgatttt 591361 atctatgtaa gactgtcctg ttttttcatt ctttttcctt ctgactttat aatcaggatg 591421 aagttttagc gttttgacgc caggtgccag catttgtgca aattgttttc ggttttcaag 591481 ttcagccata agcctgcacc tcctattagt actattttat caatccagcg ttttttgtat 591541 atgaaaaaat aaaagtacag tgccgctgtc cttttataca gcaggaaagg ctgttgaacg 591601 tgttaaaaag cagataaaat gggggcagta acagagaaaa caaaaatgta tgcacttaca 591661 ttttattttc taaagaaagg aacttgccaa atgactcaca cagtacctca aaacatgaaa 591721 gcggctgtta tgcacaacac aagagagatc aaaattgaaa cattgcctgt gcctgatatc 591781 aatcatgatg aagtgttgat taaggtgatg gctgtcggaa tttgcggatc tgatctgcat 591841 tactatacaa atggccgaat aggcaactat gttgtggaaa aaccatttat ccttgggcat 591901 gaatgtgcgg gtgaaattgc cgctgtcgga tcatctgtcg atcaattcaa ggtgggagac 591961 cgcgtcgctg tagagccggg tgttacgtgc ggacgctgtg aggcgtgcaa agaaggacgc 592021 tataatcttt gcccggatgt acagtttttg gctacaccgc cggtagacgg tgcgtttgtc 592081 caatatatta aaatgcgtca ggactttgtt tttttaatcc cagactcact ttcttatgaa 592141 gaagctgctt tgatcgagcc gttttctgtc ggtatccatg cggcggccag aacgaagcta 592201 cagcccggat caacgattgc gattatgggg atgggccctg ttgggttaat ggctgttgcc 592261 gcagctaaag catttggggc aggcacaatc attgtcaccg acttagagcc gctgcggtta 592321 gaagctgcga aaaaaatggg agcgactcac attattaata tacgtgaaca ggatgcactt 592381 gaagagatta aaacgatcac gaatgataga ggcgttgatg ttgcttggga aacagcaggg 592441 aatccagcgg cattgcaatc cgcactggct tctgtgcgcc ggggcggaaa attggcgatt 592501 gtcggtttgc cttcacagaa cgagattccg ctcaacgtgc cgtttattgc ggataatgag 592561 attgatattt acgggatctt ccgttatgcc aatacgtatc caaagggaat cgaatttctt 592621 gcttcaggca ttgtggacac gaagcatcta gtaacggacc aatattcgct ggagcagacg 592681 caagatgcga tggagcgggc gcttcaattt aagaatgaat gtttaaaagt gatggtgtat 592741 ccaaatcgct gagtgaacag ggaggatctt cgtattctcc ctcttgttta ctggaaatga 592801 aaacggattc ttggggtggg aaatgatgat tggaacagaa aaagtaacgg cattgaaggc 592861 gaagcatcag tcaaaatcca gcaccggcct gtcctggttt gaacgaatcg gttatggatt 592921 cggcgatatg tcgtataata ttatctttca gtttgtaaac gcatacttat tattttatta 592981 tacagacgtc ggcggcattc agcctgcggt aatcgcaact ttgtttcttg ttgtgcgtgt 593041 gctggatgct atttttgacc cgatcatggg attgatttta gataaaacga atacaaggtg 593101 gggaaaagca aggccatatt tgctgtgggt ggcatttcct tttgcgctat tcacattctt 593161 atgtttcacg acgcctcatt tcggtgagac cggaaatatg gtatatgcgt atgtcactta 593221 tattctgctt gggatgtcct ttagtatgca aacgatcccg gtgaacagct taacggggcg 593281 gatgacgaat tcggtggagg aacgaacggt tctgaccaca acccggatga ttttggtgta 593341 tatcggcatt cttttatcca tttcctgtgc gacaccgctt gcaactgcta tcggaggaga 593401 ggatcaggcg tttggatttc agatgacggc gctcatctat gcggctgtca gcatcgtttt 593461 gaatctattt agtttcttta ctgtacggga gcggattcag cctaaaaaga gaaaaaaaca 593521 agggatcaaa aagacgttat ccgttttatt caaaaacaaa cccttgctca tgttaatttc 593581 atcatttttg gcttttgcga tcgggtttaa tattaagctc agcacgatgg tgtattattt 593641 tacgtataac gtaaaccata aagagttcgt gtttatgggc accgttttat ttttcggggc 593701 agcgctgatc agcaatttgt ttattccttt cttttctgag aagtggggca gaaaacaagt 593761 catgattatc acggcagctc tatcgcttat ttcttatgcc ggcctgcatt ttacgccgta 593821 ttcttcaatt ccactcattt tcatttggct tttcgcttcg ggatttttca caacgccttt 593881 aaatacgctt gcttggggaa tggttgcgga ttgcgtcgat tatgcggaat ggaaaaccgg 593941 aattcgcgcg gatggtgttg tgatttcgag catgagcttt attaataagc tgggtgttgc 594001 gttagccggg tcattttcgg ccatttattt aggaatcgcc gggtatgtgg cgaatacaga 594061 ccagacagtt gcgtcgttga atgcgattaa aaatatgaat gctttgattc cgggattttt 594121 cattttgctt tctattattc ttatcgcctt ctatccttta acggaaaaaa gatataaaca 594181 catcatctct gagctggagc aaaggtctgc gagataaata gatgtaaaat ttttaatatt 594241 caatgttgta tttatggcaa aaagtaatat actgagactg taatctagac tttataaatg 594301 agtgtgataa tatgcgtagt cattctgtag tttgtattgg ggaattgttg attgatttct 594361 tttgtaccga tgttgacgtt gatttaatgg aagggcgcca attcctgaaa agtgccggcg 594421 gggcaccggc gaatgtgtcg gcagcgattg ccaagctggg cggagacgcc gctttcagcg 594481 gaaaagtagg aaaggatccg tttgggtatt ttctgaagcg aacattggac gctgtacatg 594541 tcgatacctc tatgctggtg atggatgaga aagcgcctac aacgcttgct tttgtttcat 594601 taaaacaaaa tggagagcgt gactttgttt ttaatagagg cgcggacgct ttgtttacgc 594661 tggaggacat tgaccaggaa aaactaaacg aagcgaaaat ccttcatttc ggctctgcga 594721 cggcactgtt atcggatccg ttttgctcag cctatttacg gttgatgtcg attgcgaaag 594781 acaatggaca gtttatttcg tttgacccta actaccgtga agatttatgg aggggaagag 594841 tctcagagtt tgtaagtgtt gcgaaaaaag cgatcgctgt aagtgatttt gtgaaagtca 594901 gtgacgagga acttgagatt atcagcggtg tgaaggatca tgaaaaggga gttgcgatcc 594961 ttcatgagat cggagccaac attgtcgctg tgacacttgg gaaaagcgga acgcttcttt 595021 ccaatggaaa agaccgtgaa atcattccaa gcattccggt gacatcaatt gactcaacag 595081 gggcgggaga tgcttttgtc ggtgcggctt tatatcaatt ggcaaacacg gatcagattc 595141 aatctgtaga tgctgatttt gtgaaactgc gtgagattgt ggcgtttgcc aataaggtcg 595201 gagctcttgt gtgcactaaa attggagcga ttgatgcact gccgagtttg gatgagattg 595261 gagtttcttt gtaaatcatt gaagatgttt cttgaaagtc tttggacttt tgggggcatc 595321 tttttttatt gcttacattt ttgttcaggt aaaaagttgt atattttttg tttgaaatgt 595381 cattttttat taaaaaagtg aaacttttaa cgataataaa tagtatatgt aacaagggtt 595441 accgaattag ctttaggagg aacgatataa tgagtataat tggaagattt aaagatatta 595501 tgtctgcgaa tatcaatgct ttattggaca aggctgaaaa tccggagaaa atggtagatc 595561 aatatttaag aaatatgaat agcgatttgg ctaaggttaa ggcagaaaca gcagctgtta 595621 tggctgagga gcagagagca aaaagagaat atcacgaatg ccaggcggat atggaaaaga 595681 tggaaagcta tgcaatgaag gcgctgcaag ccgggaatga gagcgatgcg agaaaatttc 595741 ttgaaagaaa aacatctttg gagtcaaagc tttctgagct gcaggcggcg aatcaaattg 595801 ctgcaaccaa tgccgcacag atgagaaaga tgcatgacaa attggtatct gacattggag 595861 agctggaagc acgcaaaaat atgatcaagg cgaagtgggc agtagcgaaa acgcaagaaa 595921 gaatgaacaa actgggcgct tctgtttcaa gtacaagcca atcaatgtct gcattcggcc 595981 gaatggagga caaagtaaat aaggcacttg atcaggccaa tgcaatggct gaactgaaca 596041 gcgctccgca ggatgatatg gctgatctgt ctgcaaagta tgacactggc ggttcaagcc 596101 aggttgatga tgaacttgcg gcgttaaaag cgaaaatgat gctcgataag taatacatag 596161 gaggccgcag ctttcggctg cggcgtcatt ttatcataaa atgtgagagg gaacggtaat 596221 gataatatct tataagtgtc cgaactgcgg cagtgatatg gcatttgaca gtgaaaccgg 596281 ctcgttatcc tgcagcagct gcggaagaca ggacaatatt gaaagccttc cgaaagaaaa 596341 cattgcggca cggttttctg atgatgaagc aaaagaatat caatgtaaaa actgcggtgc 596401 cgttttgatc acggaagctg aaacgacagc aacgacgtgc agcttctgcg gaggtgctgc 596461 aatacttgcc gatcgtttat caggacattt ggcgccggcg aaggtcattc catttacaat 596521 cagcaagcaa gaagcggagc aggcatttcg aaagtggtgc aaaaaaggcc ttctgacacc 596581 aagaggtttc atgtctgctg atcgtatcaa aagcatcacc ggcatgtata ttccattttg 596641 gatgtttgat ttaaatagtg aagtacaggt gagagcaaac tgtaccagag tccatcaata 596701 tgaagaaggg gattatattt gcacggaaac agagcacttt gaagcgtttc gtgatatcaa 596761 tctcgattat ttgaaaatcc ctgtcgatgc ctctgaaaaa atgaaagacg aattaatgga 596821 caaattggag ccttattcat acgaagagct gaaggacttt caaacggcat atttggccgg 596881 ttatattgcg gaaaagtaca attataccga tgaggagctt tttccgaggg caaaagagaa 596941 aatcagcagt tatatagatt catacatcca ttctactttt tccggatata cgtcagtcaa 597001 tgtgagggac aaacatattc acacgaaaaa cgtgaacagc ttttacgttt tgcttcctgt 597061 ttggatggtc agttacgatt atgaaagagc ggagcatatc tttgcgatga acgggcaaac 597121 aggaaaggtc gttggaaagc cgccgatcag tcgaggaaaa gtggctgcat ggtttagcgg 597181 aatagcaggc gggacatttc ttgcgttgaa gctcgtctca ttgatgatgg gaggcggatt 597241 ttgatgcgtg gattttttgg gaaagcgatc tttgttgtgc tggctgtttt catcatgatg 597301 cctttactgg gtatcgaagc ggtaagagcc tctgaattgc agcagcatgt gtacgatcgc 597361 gctcatctat tgtcaaaagc ggagatcgga aaacttgaat ctctctcggc aaagctgggt 597421 gcaaagaggg acactgattt catcattatt acgaccaaaa gcacaaacgg tgaagatatt 597481 gcagactata ccggcgattt ttatgatcgt tacggaaaag gcagtacagc cattctgacg 597541 attgatatga caaacagaga agtgtttatc gcaggcttta aaaaagccga acagtatttg 597601 gacaacagca ggctcaatag catcagaaat acgatttcat ctgatttatc caatgaaaat 597661 tattttgaag cttttgagac atatattcag ctttcctata aagatatggg cataaaaccg 597721 ggagtaaacc ctgacaacat attctttaca tggtggtttc agctgattgc tgccatcgca 597781 gtcgggggaa ttgcggtttc aatcatgctt tatcatgcag gcggcaaagt aacggttaat 597841 ggaagtacat atatggatca gcgtacgtct gatgtgattg atcaatacga cacttatatt 597901 agaacgactg taacaagaga aagaaaacca tcagataaag acagcggcag cgatggcggt 597961 gttacgaaag gcggcacgtc atacagtggg agccggggca gtttttaaat gtaagaaata 598021 gagaaaggga gaggcgtaat gtcgtttttc agaaatcaat tagcgaatgt agtagagtgg 598081 gaagaattta gagatgatat gattttttat aaatggaaca atcgtgaaat caaaaaaggg 598141 agccgtttaa tcattcgtcc cggacaggat gctgtctttt tgaacaatgg gcgggttgaa 598201 ggagtctttc aagatgatgg cgattatgat attgaatcag aaattattcc attcctttca 598261 acgttaaagg gctttaagtt tggctttaac agcggcatgc gagctgaggt gctgtttgtc 598321 aatacgaagg aatttaccgt aagatgggga acaaaacagg cgataaatat tccggcagcg 598381 ggaatgccag gcgggatgcc cattcgcgca aacggcacat ttaatttcaa ggtgcaggac 598441 tatatcagcc tgattgataa aatcgctggc gtgaaagatc aatattttgt agaggatatt 598501 aaaacccgta tcatttctat tctggatcag cttctcatga agtggatcac aagagaaggg 598561 aaagatatgt ttaatcttca agcaaacgct tttgatattg ccaagggaat tcaagaggac 598621 ttagatatgc aattaataag cgacgggatg acggtcactg gttttcaaat catgagcttt 598681 aattatcctc aagaggttca agatatgatt acaaagaacg cttcctacgg tatggttggg 598741 gatgtgaaca gataccagca aatatcaatg acggatggaa tggcatccgg aaagatgagc 598801 ggaagcggag cggcttcgga tatggctgga atgatgatgg gaatgaatat ggccaatcag 598861 atgatgaacc aaatgaatca gaatcagcag gcacagtcat caggcccaca gtcaactggc 598921 agcggaagca aaccgaattt ctgtccaaac tgcggaacaa aaacgggcga agccaatttt 598981 tgtccgaatt gcggccagaa gcttgtataa gaatcataca gtgaaaagtc cggagtgatc 599041 agcactcggg acttttttat ttaggagaat aagcattacc tattgcttgc tcctgaacag 599101 gccattttcg agcccccgct tggataattc ccagcagcaa ttgacgacgt tcctttattg 599161 aattgacggc aatttgaaat gtttgctttg ataaagccgg tatgcctgat tgttgaagct 599221 ttgagatgtc tggttctggc ggcgcttgtt ctgcaggatg gatataggca gtatgaacgg 599281 tatccagata gtttttgata cttgagcgcg cttctttgat atgaagctga ttcggctgat 599341 attgttcagg aattccgtat ttgaaaatgg ttagagcctc atccaataca gcaacagcta 599401 taatggatga ttcctgatgc tgcgtgctgt ggtaaaaatg aaggatgggg aaggcgttat 599461 gctgagcggt cagctttccc agttctgatg aggcagcgac aagaagaaaa tcaatgtcgt 599521 gaaaatcttt gccattccat gcattatgga cgatttcagt tccgtcatgc cctagactta 599581 atacactttg ggcaaaggag cgtttttgat taaccgcact caagacggaa atcaaatacg 599641 tgacagaaaa tgtgatggta agcagtcctt gagctgtttc aataatcgtg acaagcttcc 599701 ataggcctcc gttcggagcg aggtcgccat ttcctaatgt aaacatgaca tagccggaaa 599761 aataaattcg gtctgaccag gaagccggtt cttttgattg agtttccata agtgagtgag 599821 ggtcactcga gtaaatcaaa acccacccgc tccaaaatag actgatccat atcactaacg 599881 tcaggcataa cagcagagga ccagccatac ttagaacctt tgcgtggtca ccgctgattt 599941 tgcggcagcc cttccacagc caggcagaca ggcatcttgt gatcgggccg gcaccgctct 600001 ctaaccataa cgtggtccat aaaaaatcaa tcatccccgc tgtcaataat aaaaggcctg 600061 caatgatata accctcattc attttggttg cctcccttaa gtcagccttc ttttattttc 600121 ttctctattt ccttttatcc tgagtctgaa acaattgaac gaatgtttga ttttacagag 600181 aaaaataggt gggagttacc caacacttac tcatttttca atatgaacag aaaatcacaa 600241 gatttttgac ttgattcaca cattttcatg aagaaaaacg ttcattttcc ccttgaattg 600301 gtgattttcc ttttatagag taaaaaattt tcagaaattt atattgactg aaagcgtttt 600361 tataattatg ataatatcag atataacaaa aatgtcacta taacatcact acaattgaac 600421 tattaagtga ctaataaata ccaaatgaac gaggttatgc acaaagaaat gaccattgtt 600481 cttttaacga gaaatgaaat cgcttccata gggattgaca tgctaagaag aagggaaggt 600541 tatgaggtta ttggataaaa acatgaacaa ctattttctg aagcctgctt acgaaatgtg 600601 aggaaggcag cagccctgga ataagttttt gacatacgca ttttgaaaaa gactggggga 600661 aacagtatga ataaacaagg aaatcaaatg tcatttttac gtacaattat tttagtctcc 600721 actttcggcg ggcttctttt tggctatgat accggtgtgc tcaatggagc tttgccgtat 600781 atgggagagc cggatcagct taatctcaat gccttcacag aaggccttgt caccagttca 600841 cttctttttg gagcggcact gggtgctgtg tttggcggca ggatgtctga ttttaacggc 600901 cgccgcaaaa atattttgtt cctcgctgtt atatttttta tttcaacgat tgggtgtacg 600961 tttgcaccaa atgttacggt catgattatt tcccgttttg tgctcggtat tgcggttggg 601021 ggtgcatccg taacggtgcc tgcctattta gcagagatgt ctcctgtgga aagcagggga 601081 cggatggtga cgcagaacga attgatgatt gtatcaggac agcttttggc ctttgttttt 601141 aatgcgatcc ttggaacaac aatgggagac aactcccatg tgtggaggtt tatgctggtc 601201 attgcgtcac ttccagcctt gttcctgttt ttcggcatga tcagaatgcc cgagagtccc 601261 cgttggcttg tttctaaagg aagaaaagaa gatgctttgc gtgtattgaa aaaaatcagg 601321 gacgaaaaac gggcagcagc tgagctgcaa gaaattgaat tcgctttcaa aaaagaagac 601381 cagcttgaaa aagcgacatt taaagatctt tcagtcccat gggtgcgccg tattgtgttt 601441 attggattag ggattgcgat tgtacagcaa attacaggtg tgaattcgat tatgtattat 601501 gggactgaaa ttctaagaaa ttccggtttc caaacggaag ccgctttaat cggaaatatt 601561 gcgaatggcg tgatttcggt attggcaaca ttcgtcggaa tctggctgct gggaagagtg 601621 gggcgccggc cgatgctgat gacaggcttg atcggtacga caacagcatt attgctaatc 601681 gggatattct cacttgtact tgaaggatca ccggcacttc cgtatgtagt cctgtcatta 601741 acggtcacat ttcttgcttt tcagcagggc gccatttcac cagtgacttg gctgatgcta 601801 tctgaaattt tcccgcttcg ccttcgcgga ctgggaatgg gtgttacggt attctgtctg 601861 tggatggtga attttgcagt cagtttcacg tttccgatat tgctggcagc tatcgggctg 601921 tccacaacgt tctttatctt cgttggatta ggaatttgct ctgtcttgtt tgtgaagagg 601981 tttttgccgg aaacgaaagg gctttcgctt gagcagctgg aggaaaactt ccgcgcttat 602041 gatcacagcg gggcaaagaa ggattctggg gctgaagtga ttggataatt taaaaaagaa 602101 tccgcacccg agtgcggatt ctttttggtt tcaaattagt taggtctaac aaggattttg 602161 acttggcttt tctctttaat aagagccccg aagccttcct cgatcaaatc atctagtacg 602221 atttttttcg ttacgagttt gtcggctgag aaatagcctt ctttcattaa tgacaataca 602281 gccgggaaga tgtcgcggta tccgataatt ccttttactg tacgttcttt gattacgata 602341 tcgttcggat ggatttcagc acctttttcc caaatgctga cgatgacggt ttcaccggca 602401 attgtagtgg actggatggc ttgtcgtaac accactggga caccagtgac ttcgaatgct 602461 acgtcaacac cgcctcctgt acgttctgca atctcagcga ctacatcgtc tgttttagac 602521 ggatcaacga tgatcgcgcc aagctcctca gctttttgct ggcgttcagg agaaagctca 602581 acagcgtaaa tatcagttgc accggcagcc ttcagcgctt caatgacaag aagtccgatc 602641 gggccgcagc cgaatacagc cgctttgtcg cctgctttga gtttgcttga gcggacagcg 602701 tatagagcaa ctgcagaagg ttcaacgagc gcgccttgtt catatgataa ttcatcagga 602761 agtttgaaca aaagctcttc atccacagag acgtattcag agaaaccgcc gcctccgccg 602821 gctaagccga ggaatcccat ttgttcatca aggttgtagg cgccttggtg gccgtgtgta 602881 gcaaaaatcg gctcgactac aacgcggtct ccaactttat aattttcaac gccttctccg 602941 acttcgacaa cttcaccgga gaattcatgc cccattgtga caggtgccgt ttcatttgtt 603001 aatgggtgcg gtttgtcaac cggaataaag atcgggccgc ccagatattc gtgtaaatca 603061 cttccgcaga tgccgcacca tttgactttg atctttactt ttcccggctc cgtttttggc 603121 tcttcgatat gttcaatacg gatatccttt tggttatgcc atcttgctgc cttcatggat 603181 taccactcct ataacttttg atgtgagtaa ttccgcaccg gtcaatatga actgttcaca 603241 aaatcgccat ttttaaaacc aaaaaagaaa tgaaattttt atataatata atctacgttt 603301 ttttgaaaaa aagaaacttt aaagaaaaaa gggtctcgca cactcttttt tctttatatg 603361 agagtatcaa tcgtttacat agctatgaat ttggtttgaa caatacggta atggttcgtt 603421 catattgaat gcgacaacta ctctatcaat aattataact ctaatactgc tattataata 603481 ggataatctt ccatggttta ttttagcaga ggtaactttt ttgactttgt aacattactg 603541 taaggatatt gaaataaaaa atagctggtt gatcgtgtat aatcttccta gatgttaaca 603601 aacaggggga cgaaatgttg aagaaagtca ttttagccgc ttttatctta gtaggaagta 603661 ctttgggagc ttttagtttt tcatcagatg ccagtgcgaa acatgtgaac ggaaatatta 603721 cttggtataa tggagtcggg aaaaaaggct cttcaggtaa gaaacttgga cattgggatt 603781 gtgcgaccaa aatcggattt gatgttccta gaaacgggac aaaaatcaga gcttatgcaa 603841 aagcgaagcc taaaaaggtg attacggttt ataaaaatga tgttggcaga atgcctaatg 603901 cagtgctgga tgttagccct aaagcgttta aagcgcttgg atacccatta agcaaaggta 603961 aagtagcggg gcattacagc tattaatgta catatataat ctggaaagca agaagtcaca 604021 ttcttgcttt ttctattggt ggagataaaa gatgaaaaaa agaatcatat tattattagc 604081 agtgataata gcggcagctg ccgcgggggt tgcgttttat gttgcaaagg ataaaggcca 604141 tgagaaggct gctgatgttt cagtcaatac cgaaagcggt gatgagctgc tggtttcaat 604201 tacagatacg gatctgctga caaagtatta tgaaaatgac aaggtgatcc atgaggagaa 604261 gctgaccagc tatccggcat ttgccttgga tcaaaaacag caggtgctct attatacggg 604321 caataatgaa cagaatgaaa tgaggctttt taaattggat ctgaagtctc ataaaaaaac 604381 gatgctttat aaaggcgcgg agagtgcgga cagtttattt ttatcaaagg accgttcaac 604441 catctatttc cgcttaggaa aagcggacga aagcaatttt cgaatcgccg cttttgatct 604501 gaagacgaaa aagtataaaa atctttatcc tgccgctaat gatcaggatg acaccgtcag 604561 cagcttcttt tataaccaaa aaaacgattc atttgcattg cttcattatt ctgtagaaga 604621 agactacaag aaaacagatg aagcaaacga aaagggcatc gaccctgaac cgacaacgat 604681 tcattttgcg gaaggccgcc aaaataaatt taatgagctg aaaagcctga accaatttat 604741 cagcgatatt gctgtttctg atgatgataa acgtatttta ttcacatcat atacgcaaaa 604801 aggaacggag caaaccgctt ctattcaaat gctcaatgcg gatacgaaaa aatatgaaag 604861 catcatctca aatcaaaaat catttaagct gttaattgac gcacagcctc agttttctaa 604921 ggatgggaag aacatttatt ttcttgccga agccaagggg gctaaaaagc tgaaggacga 604981 aacagggcgt gaagctaagg tgcggacgat ttattcctat agccttgaga ataagacctt 605041 caaaaaagta tgggaaaatc cgaacggcat catcaacagc ttttttgtga ttaactaata 605101 aaaaccactc ggcatgagct gagtggcttt tttaatggat gaggtgcagg gctaatgatc 605161 cgagccattt aaagatatga atcagaggta ccgacaaaaa cagaagttca acatatgagt 605221 tcattgcaac attcagcttt ttgaacgcag ctcttttttt caagtctttt tgctgctggt 605281 ttgagatcac gttatcactc ctcttatatc catattatac cattaaaaca gacaaaaaag 605341 ccctaaacgt ttacagtttt gggcttcttt cttcgtattt ggcctcttgc aatgagaggc 605401 ttttattctg aaatatagaa ttttgtctcc gttcggggtt tgtttgcttg cgggagactg 605461 catttgttat agggaagaac tagcttgttt tcgtttggct gttgttttgg agattcacta 605521 atgaacggat gccgtcgacc attttacttc cgcacaaagg gcacaatggc gtatcactgc 605581 tggcgaagtt ttttcgggtc cagccattac agtcttcttt tgtgcattcc caagtactca 605641 catcttcctt tggcagcggt tcttgatttc gtttgttata gtaagacata aagtcacttc 605701 ttccctcatg tattttactg cacatttcct attgtctcat acttttccct aatctcctaa 605761 ttcctttttc tttatgactt tccaataacc ccatctaaaa aggagaggag tgtgctgtta 605821 aaagcatctg gctcttctaa aaacgggcaa tggctgcttt taggaaaggt aacgagtgtc 605881 gcgtttggaa tattgctgcg caagtgttcc ccagctgctg tagagaaaaa tttcttgtct 605941 tccccgaagc acagcaatgc cggcacattg atgttttgga gggtgccccg gtaatcagcg 606001 gccgtttggt taaataaaat cgtgctagaa atggcagccg gctgtttgag gatttctgcc 606061 agcatccatt ctgtttcggt ctcggcaggc ggttctgcga acatattctg gatgaagctt 606121 tcgtagaaag gcagcgggtc agtttgaatg gcgtgcatcg ctgtttttaa gccgtcaaaa 606181 tcaaatggac catgttccca gccctcccat tgatagtccg aagcggattg atcgatgatc 606241 acagcggctt gaatgttatc attcccaaac tgattgagat aatcccatac gacaaaagca 606301 cccattgacc agccggcaag aacgacatga tcaagctcca ttgcatttag aaattccctt 606361 atgtcacggg catattggga aatggtgtgg ccgtgaagca ctttgtcaga ttcgccgtgt 606421 cctctaagat caagacgaat acattgataa ttggcagaaa gcaccgaaaa ttgtttgtgg 606481 aaaaattgtc cgctcatcag caccccatgt ataaacagga tcggcgtccc gctcccgtgt 606541 gtttcatagt aaaggcgtgt ctgatcttct aatatgatgt atggcatgtt tctcctcctt 606601 tagtttccat catgagtatg gctggctgct gttgagctga tgatggcagc tgtcgcggct 606661 gcctgctgcg cttgaatgac tgtttcgata gcggtgtata gtcctgattc catcagcaga 606721 tttttctcca tatgctcact gagatagagg ctgacagcaa ttttaaagtt catttccttt 606781 tgccatttaa aagctttttc ctggtttaat tcgtcagtga tgcacaaaac ggttttgata 606841 tctggctctt ccagaaatgt gaggagagca aggtctggat aatgataatc ctttgttttt 606901 ttgacagatt cagtgatcga ttgatatatc tgtttgcaag cggaaacaag catttcgggc 606961 tctttttcac tttgcaaggc cagaatatgg ctgacctgat gtaagtactg tcctttttta 607021 aagccgttgg ctgccagcag ttgatagcat gtttccgcct tctgtagcgc ctgcaaacct 607081 tttccgtttt ctccaagcag tacggcaagc ggaacattct gagttgaagt gaggaaataa 607141 tgatttttct tcatctgctg ataaacagct agccccatgt tcatctgttc tttttggttt 607201 gtcgtttcag atttgccggt gagcaagatc agagcggaaa ggtatgtgaa catatcccgc 607261 ttatacccta gcttcaccat ttcattgtat acatcgatga aagtctgaaa tgtttgtttt 607321 gcctcatgct gaaaatgaat gtccagaata gatgcaacag taaagcggtg gtgtgaattg 607381 agtgttgaga agctgccgat gtttgatttg atatagctgc tcaaatcata aaagcgctga 607441 aaatcaaact ctcttttatt cacaatatat gcagaagaaa tgagcattaa tatctgatcg 607501 tgtgaaactt tccattttaa ttttgttttt aattcagcat aaatggaaat gtaatgcttt 607561 gttttttcat gtagatcgtg tgtgagcata aaaagcagct ccttttgttg tttttacgta 607621 atacgataaa tagggccaaa ggtttcataa agaaaaaact tgcctgctag aggcaagttt 607681 gtcgggttat ttatggggat cagttatatc catcggtctc atcatgtcat agtcttcatg 607741 ctctagaata tggcaatgcc atacgtatcg tccgctgtac ggaccgaatg tcgccgcgat 607801 tctcaggact tcacctgcat gcgcttgaat ggtgtctttc cagccctttt cacttggcgg 607861 cggcgggaca gccggaccgg tataggacaa ttccccgctt tcttgataac gggcgatatc 607921 aaacggccgc cggtctaata cacggaagga gactagatgc aggtggatcg gatgtgttcc 607981 gcgtgtcggg ttgataatgg accatatttc agttgtgccg acttttggtg tttctgtgac 608041 gggatcgtgc cagcgtttgt tattaagcag aaggacgggt ctgccgtatt cgtcctgggt 608101 gcctgccagt tttaacgttc tgatgttttg tattctttca tgctgtaccg aagggtatga 608161 ggcgaggtac ttcggctttc tgctttcgtc tttttgtgcc aatggttttg tgactctgaa 608221 ttgcatgata ttcgcatctg tttcaggatt gacgtcaccg ccgcagcccg cgctgtttgc 608281 caaaatgatc gattctcctt catatgctgt gaagtcaatg atgatatcgt aacgttcagc 608341 aggcgcaagg ctgaaagaat tcagtttaac agatcgcggc aggagccctc catctgaacc 608401 aatctgaata aaatctccgc cattatcgag tgacaggtta taggttcttg tattggaggc 608461 gttgatgaca cggaatcggt atttccttgg ctcgacttcc aagtatggcc ataccttccc 608521 gttgacgagt atggtttctc cgcaaaaagc cggaacgatt gaaggattag gcagtgacgg 608581 agaagggttt tccggtgcgc tcggataaaa caaagaacca tcctcattga tcgtgcggtc 608641 tgtgataaga agcggcacat cgtattcgtc tgaaggcagt tttaagcgtt tttcctttgg 608701 gtcatgaatg atatatgcac cgacaagtcc ggcatagaca tttagcctgg tgagcgccat 608761 ggcgtgatcg tgataccaca atatagcccc gcgctgctgg tttggataat gataaacctc 608821 tcttttgaaa taaggtcctg tttgttcaaa gtctttggaa aaccaagcct ccggataccc 608881 gtcactatca tctggcgtga cgccgccgtg taaatgaaca acagtcttta cctcgggctc 608941 ttcatgctgg ctgtcactgt gatgaatggt gtgatcaatc ggaaggaaat gcgtggaagg 609001 aaggttattc atccatttta catatacgtt ttcatttctt ttaacctcaa tggtcggtcc 609061 cggaaataag ccgttgtagc cccacaggcg ggttggaggg agatcgcgat ggagctgatg 609121 agtgcattcc tccatggtga cttcgtagta tgttttttct tttgattgct gtactggctt 609181 tagtgtatct gggattggga gagcatccac aaatttttca agtgtcattt tcatctgtcc 609241 ttatctaaat tttccaaatt ggtactatag ttaatgacaa taaggacgtg atggttacaa 609301 aaaatcttcg tgctgcagcc cgcccgaaga agaaaataac aaaatcctaa acggcaggcc 609361 gtttaggatt tgatcagcat taaggcagga tatcgggttg ctgctgtgtg actgggttgg 609421 cagccgcttt ctcgctcacc ttgcgttttc tgaacacaag gtaagaaatc agaacgattc 609481 ccgtgatgac gcctgtcagc agcagctcgt ctctcatgga atcaataaac gccatggaca 609541 ctaaaattcc gcaaatggcg atgatggtca agtaggttag gaaagggaag agccacattt 609601 tgatcttcaa tgcttctggg tttgtttttt cgagtttttt ccgcattttc agctgggaaa 609661 cggcgatgac aagatagacg agtaaagcga ttgcgcctga tgagttgact aagaataaaa 609721 agacggtatc cggtgaaaaa tagttcatta cgaccgcgat ataagagaaa aatgtcccgg 609781 ccacaatggc ttgtacggga acgccttttt tgctcaattt cataaaacgg cgcggcgctt 609841 catttctttc tgcaagtgaa tacagcattc tggatgtggt atacaaacct gaattcaggc 609901 aagagagtac ggctgtgagg acgataaagt tcataatctg tgcggctgcg ggcactccta 609961 tatgctcaag tacagcgacg aaagggcttt ctaaaatatt tgctgaattc catggcaaca 610021 gcgccacgac aatggcgatt gagcccacgt aaaagacgat gatgcgccat acaacggatc 610081 tggtggcttt tgtcacagat tcgatcgggt tggatgtttc ccctgctgca atggcaacga 610141 tttcagttcc cataaaagag aagatgacaa cgacaatgcc gagcaatacg gagctgatgc 610201 cctccgggaa aaatccgcct ttgcctgtaa gattcgaaaa accgactggc tcactgcccg 610261 gtgcaaagcc aaaaataaag gcaaaaccaa cgattagaaa agcaatgata gtcacaactt 610321 taatgaggga gaaccaatat tcaaactcac cgaaagactt aacggagtag acgtttgtca 610381 gggtgagcac aatggtcaag atcaaacttg tcagccacag cggaatatca tggaaccagt 610441 attgaataat gccagcaccg gcaatggctt cgatcgctat gacgatcacc cagaaaaacc 610501 agtacagcca gccgattgta aatcctgccc acggtccgat ggcgtcgtga gcgtattgag 610561 aaaacgatcc gctcgtcggg tttacggcag acatctcacc gagcattctc ataataaaaa 610621 tcaccaataa tccggctaac gcgtaagaaa caacggcacc cggaccggtc gagtgaatca 610681 ctgaaccgct gcctacaaat aggccggctc cgattacacc ggcaatcgaa atcattgtca 610741 tatggcgggt ctttaattcc ttttttaatc ctgattgaga ctggttcata agttacctcc 610801 ttttaaaatg caatcattac tgaatattat gataattgaa actctatcat aaatatacag 610861 tttgtcgaaa attcgtgtaa gaaaatatac cagcttattt caaatttgta gtgttttgtt 610921 tgcgctttca gcgaatgtgt ggaaaaaatg tttcgttttt tattcgctgt gtgattttgc 610981 gtaatattta caattcgata gaatgcgaga agcactggtg tccttgggtt tgatgggatt 611041 tttggcggag caaataaatt ggatgagaga aaaagtgttc cttcgtcact atttttctgt 611101 ggcgggtgaa tcatgtttct gtagacccac tgcggatcag ctttgtaaga taataatagg 611161 aaaatgtgag cgagaggagg ttttgtatgg agagatatga tgaactgaaa aagggagaat 611221 ccggagcgct ggtcagcatt gccgcgtatc tagttctttc cgcaattaaa ctgatcatcg 611281 gttatctttt tcactcggaa gcacttacgg cagacgggtt aaataacaca actgacatta 611341 ttgcttctgt tgctgtgctg attggcctgc gcatctctca aaagcctcct gacgaagatc 611401 atccatacgg ccactttcga gcggaaacga ttgcatcgct tatcgcatcg tttattatga 611461 tggttgtcgg actgcaagtg ctgttcagcg ccggagaatc tattttttct gctaaacaag 611521 agacgccaga tatgattgcg gcttggacgg cagcgggcgg ggcagtcctg atgctgatcg 611581 tttaccggta caataaaagg ctggccaaaa aggtgaagag ccaggcgctc cttgctgcgg 611641 ctgctgataa taaatcagac gcattcgtca gtatcggcac atttatcggc attgtggctg 611701 ctcaattcca tcttgcttgg attgatacgg tcactgcgtt tgtgatcggt ctgcttattt 611761 gcaagaccgc atgggatatc tttaaagagt catctcactc tttgacagat ggattcgaca 611821 taaaggacat ttccgcttat aaacagacaa tcgaaaaaat ctccggtgtg agccgtttaa 611881 aagacataaa agcaagatac ttgggcagta cggttcatgt tgatgtggtg gttgaggtat 611941 cggcagattt aaatattacg gaaagccacg atatagccaa tgaaattgag cggagaatga 612001 aggaggagca tgcgattgat tattcgcatg ttcatatgga gcctttagaa caaaaataat 612061 ggagcttcct gtcacaggaa gcttcagcgt gtcgacaaac cctcgcattc gttgtcaggt 612121 ctgcgcttcg gtgctcacga attagaacat tcgctccgct cctatgctcg tccttcctag 612181 acttcaaggg ttttcaatca cgctgaaaag atgacaaaac cctaaaatga aagccatttt 612241 aggattttgt caacaatctg gagcttcctg ccacaggaag cttttttgtg tgttttggcc 612301 agctttattg gtaacaattt gctagaatcg tttttttata cagattgctt tttgtggtaa 612361 agttaggtta cattatgatg aattttgtag atgactagga ggaaaataat ggcatatcaa 612421 gaagacctgc atcctttgct ggggaaagca gttgaacata ttaatagagt aatggttgga 612481 aaacgagaca tcgccatact cagcttagca gcccttcttg ccaaagggca tgtgctgctt 612541 gaggatgtac ccggagtcgg aaaaacgatg atggtccgcg cgctggcaaa gtcaatcggc 612601 gccgatttca aaagaatcca attcactccg gatttgctgc catctgatgt aacaggggta 612661 tctatctata atgcgaaaac gatggaattt gaatatcgtc ccggcccaat tatgggaaat 612721 atcgtgctgg cagatgaaat caaccgtacc tctccgaaga cacagtcggc tttgctcgaa 612781 gcgatggaag aggggagcgt cacggtagat ggccatacga tgcagcttgc cgatccgttt 612841 tttgtgatgg caacgcaaaa cccggtcgaa tatgaaggga cctatccttt gccggaagct 612901 cagcttgacc gttttttatt caaacttcgg atgggttatc cgtcctttaa tgaagagctt 612961 gacgtcttat ctcttcagga aaaaagccat ccgattgaga cgcttgagcc ggttattgca 613021 aaagaagact tcatcttttt acagagggaa gtgcaaaatg tccgtgctga tgacagcatt 613081 aaggaatata tcgttgaaat tgtgcagaaa acgagacagc atccttctgt tcaattaggc 613141 gtcagtccgc gcggctcaat cgccctcatg aaagcggcac aggcatacgc gctgctgcat 613201 catcgcgact atgtcatacc ggatgatatt caatatttag ctcctttcac gctgccgcac 613261 cggatgatgc ttcatcctga ggcaaaattt gaagggattc aggcagaagc gatcgtaagg 613321 gagatcatgt cagctgtgaa ggtgccggtt caaaggtcgg cggtccgctg atgaataaga 613381 aatggcaatg gctcgtatat ggttggaagc tgattatatt aactttattg acggctgctg 613441 ttttttctta tgcgatgttt cagggcggct ttgtcagctg gtttttgttt tacgcgtttc 613501 tcccttttgt cttgtatgcc gggctgttgg ccttgtatcc gctccgttct tttcaggctt 613561 caaggcaaat ggataaaaca caattgcatg cgggggacag gctgggcgta acggttacgc 613621 tgagaagaaa gctgccattt ccgctgatgt atatggtgat tgaagattgc ctgccagaag 613681 gtatcgagtc attaaatcga gacggagccg cggccaaacg gctcgttttt ccttggttta 613741 aacggagcat gacgatgtcg tatgaattag ctcgggtacc gcgcggagag catcactttc 613801 attctgtcag ggtgcgaacc ggggatgttc ttggcttgat tgaaaaaaca gcattttttg 613861 agctggatga taccttgttt gtttatccat tctatcagcg tttttcctat caggtgaatg 613921 agaggcatca ggaagacggt gtaagcggtt cttctcctat tcatcagcac cattcctcag 613981 tcgcagcaag tgtgcggaat tatcagccgg gagaccggtt tgctgcgtta gattggaaga 614041 catctgcacg gcggagccag ctgatgacga aggaatttga gccttctcgc agcaaaaatc 614101 tgtttctgct gatggaccgt ttttcctcag acgcattcga agaggtcgtt tcagtgacag 614161 cttcgattct tcattctgtt ttaaaaaacg gcgcgggtgc tggtctggct tccatcggga 614221 aggaaaaaaa cattttccct attcaggaag gggatcagca ttttaagcac atgcttcggc 614281 atttagccat cgctcattgt gatgcggcag acccgataag ccgatatgca cgggaagagc 614341 tgggaaagcc atctgttcgc caagctgatc aagttgttgt cacgggacag ttaacggaag 614401 atatgctgca cctcgcagaa ataggaggcg gccgggttac ggtgatactg gcaaaagaga 614461 aagatgctga gctctctcaa gctgaaaatg tcatgattga acgcatgatg aaacgccaaa 614521 tcagagttcg gatcatgagg ggcgggcgag tttcgcgtgt tgtttagaaa gagaggtgac 614581 tggttcacat gccgcacgat gatcacaagg gaagccgttt gagcttgctg ttattttatt 614641 ttctggcttt tttattgctg tgggagtggc ttaggccgct tgacagtttt actgaaacga 614701 aacatacagg cttttttagt gtctttatcg gcttgacgtt tctgctgact tttttcagga 614761 tgaggtggtt tgtcaccgtt cctttttgtg tcatatttac attgatctcg atacacatcc 614821 tgttttatca aggatctata ttcgacttga gctgggtcag ctcttttttg caggatgtct 614881 atctgaatat cacgctgatt caatcagggc aatggaatga catgattcct tcatttcgga 614941 ccctgctgtt ttttgtgctg ctgtggctgc tggtctatct cctgcattat tgggtgattt 615001 accagagaag aattttgttt ttctttttga tgacagtagc gtatattacg attcttgata 615061 cctttacgcc atatgatgcc acttttgccg taatccgtat cgtgctgatc ggcttcttta 615121 tgctgggcct tttatacttg gaacgcatta agctgatgga aagaatcaca ctgccaaaaa 615181 catctgtcct gaaatggttt cttcctttat ctgtattggt tttggctgca acgggattcg 615241 gactcgccgc tccaaaatca gagccggctt ggcctgatcc ggtgcctttt cttaaaaaaa 615301 tcactcatca agaccgcgtg tctgcagggg aaagcaaaat cggatacggg aatcatgatg 615361 aatcactcgg cggcccgttc cagcaggatg ctacacctgt ttttacatgg cagggaaaag 615421 agcgtacgta tttccgtgtg gaaacgaagg acacgtatac cggaaaaggc tggattgaaa 615481 cagacacagg catgtcgtat cagcttagca atggaaaagt tgaaaatctg tggtttgacc 615541 ataaggttgc gacagagcgc cgcaccgtcc gtgtaaaagt cgataagcac tacgggtata 615601 accatctgat gtatccgatt ggtgcggaaa ccattcagcc aaagcaggct gtctcacttg 615661 aaatgaacgg caacacggag caaatttctc cgatcagtga acaagccggt gaaatcagaa 615721 atatggggaa ttatacagta acgtacaatt ccccggtcta taagctggat gaactgagaa 615781 aggtaaaagt gagaaaaaac agtgaggagt acacattcag cgatcgctac atgcagcttc 615841 cagattcact gccagagcgg gtgagaaccc ttgcgatcaa actgactcag gatcacgaca 615901 atatgtttga taaggtgaaa gcggttgagg actatttagg gtcaaatgcg ttcacatatg 615961 aaacagaaaa cgtgaccatt ccgaagaatg atgaagatta tgtcgatcaa tttctctttg 616021 aaacgaaaat gggttattgt gataactttt cttccgccat ggtggtgctc ttgcgctcgg 616081 ccggcattcc ggcccgctgg gtaaagggtt atacgtccgg cgaatacaaa gaagcaggga 616141 acaaaaatgg cagcatttac gaagtgacaa ataacaatgc ccattcctgg gtagaggtgt 616201 atttcccgga acagggctgg gttacatttg agccgactaa agggtttaca aatccggctc 616261 aatttacatc ttctgacaca aaagactctg gcagcgatag cagcagctcg ccgaagaaag 616321 caaaagagaa acagaaagaa gagaaaaaac agccgcaaaa agaggaaaaa caaaaggaaa 616381 agcgggagcc agctgtttct aaaaagccgt ccgcttcgca tactaatgcc ggtgcgggct 616441 tgtatgcagc gcttgcggtt cttgcagtcc tcctggtggc agctgtattg ctgtatgttt 616501 tccgctcgtt atggattcct gttttcgccg tgaggaaatt gaagcggcgc agtgatcagc 616561 acgcgttttt tgaggcatat ggcgcgctgc tgaaacaact gaagagaaaa ggactgccga 616621 aacgagacag tgaaacgctg cgtgattatg caaaacgaat tgatgaaaaa tacgacatag 616681 aagacatgtc aaagctgaca ttaagctatg aaagggcgct ttacagaaat gaagattctt 616741 cggcgctatg gaatgattcg agagagttat gggaaaattt aattaaaaga agatggtctt 616801 gaccgcttat cgacgtgttg ttagaattag tgaatattat cggagtctgg gagcgagttg 616861 gcctgactcc ggcaaacggc cttgccaaag agggcggagc gagcttcata tctgtcctcg 616921 tttttttctg tgtcaaaaaa cttagaggag attaggtgac aaccatgaca aagttagtga 616981 atgaaatgat tcttgtcctt gatttcggca gtcagtataa ccagctgatt acacgccgta 617041 tccgtgaatt cggtgtttac agcgagctgc atccacatac attgacggct gaagaaatta 617101 aaaaaatgaa tccaaaagga attattttat ccggcggtcc aaacagtgtg tatgatgaaa 617161 actctttccg ctgtgacgag aaaatcttcg agcttgatat tcctgttttg ggaatttgct 617221 acggcatgca gctgatgact cattaccttg gcggtaaagt tgaagcggca agccagcgtg 617281 aatacggaaa agcaaacatc cgcatcgaag gcacacctga tttgttcaga gatcttccga 617341 atgaacaagt ggtttggatg agccacggcg atttggttgt agaagttcct gaaggcttca 617401 ctgttgacgc gacaagccat cactgcccga actcagcaat gagcaaagcg gacaaaaaat 617461 ggtatggcgt tcagttccac ccggaagtgc gccactctga atacggcaat gatcttctga 617521 aaaactttgt attcggtgtt tgcgaatgcg aaggcgaatg gtcaatggag aactttatcg 617581 aaatcgaaat gcaaaaaatc cgtgaaacgg tcggagacaa acaggttctt tgcgcgctaa 617641 gcggcggcgt tgattcctct gttgttgctg ttttgattca taaagcgatc ggcgaccagc 617701 tgacttgtat ctttgtagac catggtcttc tccgtaaagg cgaagctgag ggtgttatga 617761 aaacattcag cgaaggcttt aacatgaatg tgattaaagt agacgcaaaa gatcgattct 617821 taaacaaact aaaaggcgtt tctgatcctg agcaaaaacg caaaatcatc ggtaatgaat 617881 tcatttacgt gtttgatgat gaagcggaca agctcaaagg catcgactac cttgcacaag 617941 gtacgcttta cacagatatc atcgagagcg gtacagcaac ggcgcaaacg atcaaatctc 618001 accacaatgt cggcggactt cctgaagaca tgcagtttga gctgatcgag ccgttaaata 618061 cgctcttcaa agacgaagtg cgcgcgcttg gcacagagct cggcattccg gatgaaatcg 618121 tatggcgtca gccgttccca ggaccgggac tcggaatccg cgttcttggc gaagtaacag 618181 aagaaaaact tgaaatcgtt cgtgaatcag atgcaatctt gcgtgaagaa attgcaaatc 618241 acggcttaga gcgtgatatc tggcaatact tcactgttct tcctgacatc cgcagcgttg 618301 gtgttatggg tgacgcaaga acatatgatt acacaatcgg aatccgcgcc gttacatcaa 618361 tcgacggcat gacatctgac tgggcgcgta tcccgtggga tgtgcttgaa gtcatttcga 618421 cacgtatcgt aaacgaagtg aagcacatta accgcgtggt gtatgatatt acaagtaagc 618481 cgcctgcgac gattgagtgg gaataagaat caattaatgg aaaccatctt tttggcaatt 618541 ttgccgggaa gatggtttta tttgtttatt acgaacaaaa tccgattttg cgcgactatt 618601 gttcgctttt tgtattgttt tttcaaaatg aacttggtac aatagacaca gaaatcaaat 618661 aagatgaatt cgtataatcg cgggaatatg gctcgcaagt ctctaccaag ctaccgtaaa 618721 tggcttgact acgtaaacat ttctttcgtt tgatataaat aaaacacggt tatttattca 618781 aactgaaatc cgtctgtagt caagcgtccc aaaatgtatt gggacgtttt ttatttggcg 618841 ttttcaggac agaataaata gcaaagagtg aagggagtca aatagcttga aaacgttttt 618901 tcagtttgat gagctgggca ccagctatcg caatgaaatc attggcggat taacgacttt 618961 tttatctatg gcatatattt tgttcgtcaa tccgattacg cttgctttgg agagcgtgaa 619021 agattttccg gaggcgctga gaattgacca gggtgcggtc tttacggcga cagcgctggc 619081 gtctgcagca ggctgtatct taatgggatt aatagcgaga tatccgattg ccatcgcgcc 619141 gggtatgggg ctgaacgcgt tttttgcgtt ttctgttgtc cttggtatgg gtatttcatg 619201 gcaggcagct ttgtccggtg tttttatttc aggtcttatt ttcgttgctc tttctttaac 619261 aggttttcgt gaaaaaatca tcaacgccat tccgcctgag ctgaaattgg cagtcggtgc 619321 ggggatcggc ctgtttatta catttgttgg attacaaggt tcaggaatca ttacagcgaa 619381 tccttctacg ctcgtcacga tcggaaacat tcacagcggt cctgtgctgt taacgatttt 619441 cggtgtgatt gtcacggtta ttttaatggt gcttcgcgtg aacgcaggcg tgtttatcgg 619501 gatgctatta acagcggtag ccggcatgat tttcggtttg gttccggttc cgactcaaat 619561 tatcggcagt gtgccaagcc ttgcgccgac tttcggacaa gcgtggattc acctcccgga 619621 tattttctct gtacaaatgc tgatcgttat tttaacattc ttgtttgtcg gattttttga 619681 tacagctggt acacttgttg ctgtggcaac acaagctggt ttaatgaagg aaaacaaatt 619741 gccgcgtgcg ggccgtgcgc ttttagctga ttcatcttct attgtgatcg gtgccgtgct 619801 tggtacgtct acaacaactt cttacgtgga atcaagctca ggtgtcgctg cgggtgcccg 619861 gtcaggattt gccgcaattg taacagggat tctcttttta ctggctacgt ttttctcgcc 619921 gctcctatca gtcgttacgt caaatgtaac agcgccggcg cttattattg ttggtgcatt 619981 gatggtggcg ccgcttggca aaatcgcttg ggataagttc gaagtggccg ttcctgcttt 620041 ccttaccatg atcatgatgc cgttaacgta cagcatcgcg actggtattg ccatcggatt 620101 tattttctat ccgattacaa tggtgtgcaa aggaaaagca aaagaggttc atccaatcat 620161 gtacgggctg tttgtcgtat ttatcctgta ctttatcttc ttaaaataag gaatgaaaaa 620221 ccagctgcac tggcagctgg tttttttgtt gcaaaagata aaaccatttc atacgatata 620281 ccgtcatgta gatgtgccgc catgctttac ttaaatggaa atgacttgac tgttcaggaa 620341 ggcttcggta ccttatataa gtgttttatt ttcttgctga atggtattcc gccgtatttt 620401 tttgatagga gttgctgaca tgacggaaga aagaaaagaa acgtttgaag aagaaattaa 620461 ccagagtgaa agaatagatg cagatgaaga accgctatcg agaatgtcca gaaaggcgag 620521 ccggcaaagc aagcagaagc aaaaacaaaa gcagaaaccg cgccaggaac gcggtgaatc 620581 aactgttaaa gacaagcttg cgtctgtttg ggcagccatc aacagatatt gcggttttgc 620641 gttctcgatt ttaaaatctc cggcgaaaac tgtcgtaacg gatggttttt ctcattataa 620701 gtacggtctg atttcaatgc ttatattcag tatcattttt tcaattggga attggtttca 620761 gttaaaggca agctggaatc ggccgctcgg tttcggagaa cgccatcatg ctttctatga 620821 cgggttttta gttgttcttg tgtatttgct gatctttttc gcggtaatgg tctttgctat 620881 atgggctgtc tcccgctata tgatgaagca gaaggtgacg ttcagagaag cggctgccgt 620941 attgggttca ttgcttgtac ccgtaattgc tgtttcaatc ctttggctga tctttgcgat 621001 cgtaaatatc ccaatgctga cagtactgtt tacggtgctg atcttgtttt ccatcttttt 621061 tatcatcgcg ctgtatgtac agcgtgtgta ccaggcggca caagatgcac caattgatta 621121 tatctattgt gtatttgcag tagttgcgat agcgctgctg tttacggcag tgacttggcc 621181 gtttatttct gaatatatta cggcgtcgtt gattccgctt taatgaaaaa accggctaat 621241 cctagccggt ttttttatgt cacacttttt acaaatatat ctaaaaaaca tagttgattt 621301 gtaggattaa cccgtgtatg atggggaaaa tgctgaaaac gtccagcgca aaaaccttta 621361 tgtttaagga ggatgatgga catggctgat gtacttcgcc gagcaattaa ccaaaagaag 621421 caatttttaa aaaccaaatt actgctctcg gaattttatc aaggaagagg ggaacagctt 621481 gctgactaca cgctgagtga gcttgagaaa gaatacaagt cccttcagaa aatgaaaaaa 621541 gagatctgac aatagatata aagaggtgag tctgctgaaa agcgggcttt tttgttttga 621601 ttttgaaaag gcgagaaaga gggtaaacta ctactgttca acacataaaa gcgtgtcgaa 621661 atattttgct taagcttacg ggcgaagctg attgtaaacg gctcatttct ctagtagaat 621721 atgaatgctt tgtgcaagct gaagagtagg gggatgaata aaatgatgca aaccatctta 621781 tcaaatggga tagccatggt tctcataatt ctcattatta atattgtcta tgtgtcattt 621841 tttacgataa gaatgatttt aacgctgaaa ggacagcgtt atttagcggc cggcatcagt 621901 acgattgaaa tactggttta tgtgacagga ctgagtctgg tgctcgataa cttagaccag 621961 attcaaaatg tgatcgcgta cgcgctcggt tacggtcttg gcgtaattgt cggcatgaaa 622021 atagaagaaa aattggcgct tggctatatt atggtcaatg tgattacgaa ggagctcgat 622081 cttgatcttc cgaagcagct ccgtgaaaaa ggctacggcg tgacaaactg ggtggcaggc 622141 gggcttgaag gcgaccgcac agcccttcag atcctgacgc cgagaagata tgaactccag 622201 ctatatgata cgattaaaac acttgattca aaagccttta ttattgcgta cgaaccaaaa 622261 acaatccacg gcggcttctg ggtcaaagcg gtgaagaaga ggagaattaa agaataatgg 622321 caaagccgaa gaagaaaaag tttgaagtga cagagcagca aacgattgat gcggtgcttc 622381 agcaaatgaa agaagaagga tatctgcctg taaggcgaat ggaagagcct atttttatgg 622441 aaaaaaagga aaatgggtca attcagatcg ttccgtgcgg gaaaaaaatc gtatttgaag 622501 ggaaattgat ctaaaacacg aacattagta gaatgaattt ttgtatcgtt cgataatatc 622561 gttgacatta tccatgtccg ttgttaagat aaacatgaaa tcaaaacacg acctcatata 622621 atcttgggaa tatggcccat aagtttctac ccggcaaccg taaattgccg gactatgcag 622681 gaaagtgatc gataaaactg acatggatat atcgcagaag cgaacgactg acgatacatg 622741 taccatgccc ggtttgtatt gcttcctcat aagtgcaatg cagagcgggt attttttatt 622801 ttctgaaaac aaaagcatta gaaggtgggg aacagaatgc agccgctagt aggaatcatc 622861 atgggaagca cttccgattg ggagacaatg aaacacgcat gcgacatact tgacgaactc 622921 aatgttccgt acgaaaaaaa ggtcgtttcc gctcaccgga cgcctgattt catgtttgaa 622981 tatgctgaaa ctgctagaga aagaggcatc aaggtgatta ttgccggtgc cggaggagcg 623041 gcgcatctgc cagggatgac ggctgcgaaa acaacactgc cagtcattgg agttccggtt 623101 cagtccaagg cgctgaacgg aatggattca cttctttcca tcgtccaaat gcctggaggc 623161 gtgcctgttg cgacaacatc catcggcaaa gcgggtgctg tgaacgcagg cctgttagcg 623221 gcgcaaattt tgtcagcatt tgacgaagac cttgcccgta agctggatga gagaagagaa 623281 aatacaaaac agacagtgtt agaaagcagt gatcagcttg tctaaacaaa tcatctatcc 623341 gggagctgta atcggcatta tcggcggcgg ccagcttggg aaaatgatgg ctgtgtccgc 623401 caaacaaatg gggtataaag tcgcggtcgt tgatccggtg aaagattcgc cgtgcgggca 623461 ggttgcggat gtcgaaatta ccgctcatta taatgaccgt gaagcgattc gaaaattggc 623521 tgaaatcagc gatatcatca catatgagtt tgaaaacatc gactatgatg cgctgcattg 623581 gctaaaagat catgcgtatc tcccgcaagg aagtgagctg ctgcttatta cccaaaaccg 623641 tgaaacagag aaaaaagcaa ttcaatccgc gggctgtgaa gtcgcaccgt acagcatcgt 623701 caaaacaaag aatgaattga aacaggcagt acaggagctc aggcttccgg cagtgctgaa 623761 aacatgccgc ggcgggtacg acggcaaagg ccaatttgtg ataaaagaag aggcgcaaat 623821 ggagcaggca gccgctctgt tagaacacgg aacttgcatt cttgaaagct gggtttcttt 623881 taaaatggaa ctgtcggtga tcgtcgttag atcggtaaac ggtgaaattt caacatttcc 623941 gacagctgaa aacattcacc acaacaatat tcttttccaa agcatcgtgc ccgcacgggt 624001 agagaaaggg attcagcaga aggctgctga tctcgcagtt aagcttgcag atgagcttaa 624061 ccttgtcgga ccgcttgctg ttgagatgtt cctgacagag gacggagagc ttttggtcaa 624121 tgaactggcg ccaagaccgc acaattcagg gcattatacg ctggaccttt gcgagacgag 624181 ccagtttgag cagcatatca gagcggtatg cgggcttccg cttgggaaga cagatttgct 624241 gaagccgggc atgatggtga atcttctcgg cgatgaagtg aagcttgttg aggaagaccc 624301 ggagctttta aaagaggcaa agctatatat atacggaaaa catgaaatca aaaaaggccg 624361 caaaatgggg catattacat ttatgaagca gcctgaagac gaatggattc aggagatcac 624421 aaataaatgg atgaatagag acggaggaca agcagaatga tcgaacgtta ttcaagacct 624481 gaaatgtccg cgatttggac ggatgaaaac agatttcaag catggttaga ggttgaaatt 624541 cttgcctgtg aagcgtgggc ggagcttggc gtcattccga aagaagatgt aaaggttatg 624601 cgcgaaaacg cgtcatttga catcaaccgc attttagaaa tcgaaaagga cacgcgccat 624661 gacgttgtcg cttttacgcg cgctgtatcc gaatcactgg gcgaagaaag aaaatgggtg 624721 cattacggct taacgtcaac tgacgttgtt gatacggctc tttcctactt attaaaacag 624781 gcaaacgata ttttgctcaa ggatcttgag agatttgttg acattataaa agaaaaagcg 624841 aaagaacata aatacacagt catgatgggg cgcacacacg gcgtacacgc tgagcctaca 624901 acattcggct taaaacttgc gctttggcat gaagaaatga aacgtaatct tgagcgcttc 624961 aaacaagcga aagcaggcat cgaggttgga aagatttccg gtgctgtcgg cacatatgcg 625021 aacattgatc catttgttga acaatatgtc tgtgagaagc tcggattgaa agcagcaccg 625081 atttccactc aaacccttca gcgtgaccgc catgctgact atatggcaac acttgctttg 625141 atcgcgacaa gcatcgagaa attcgctgtg gaaatccgcg gactgcaaaa gagtgaaaca 625201 cgtgaagtag aggaattttt cgcgaaaggg caaaagggtt catctgcaat gccgcataaa 625261 cgaaatccga ttggctctga aaacatgaca ggcatggcgc gcgtgatccg cggctacatg 625321 atgacagctt acgaaaatgt tccattatgg catgagcgcg atatttctca ttcttcagca 625381 gaacgaatta ttcttccgga tgcgacaatt gcgctgaact acatgctgaa ccgcttctcc 625441 aacatcgtga agaacttaac ggtcttcccg gaaaacatga agcgcaacat ggaccgcact 625501 ctcggcctta tctattctca gcgtgtgctc cttgctttga ttgacacagg cctgactcgt 625561 gaagaagcct atgatacagt tcagccgaaa gcaatggaag cgtgggaaaa acaagtgccg 625621 ttccgcgagc ttgtggaagc ggaagagaaa atcacgtcac gtctttctcc agaaaaaatt 625681 gctgactgct ttgattacaa ttaccatctg aaaaatgttg atctgatctt tgaacgttta 625741 ggtttagcat agaagaagct tttagcggct tcttctaagc cgccgcagtt tgaaaattcc 625801 caacattcgg gttaggaggc cttccgtgaa tattgtgaag aatgaacttt tatacgaagg 625861 aaaagcaaaa aagatctaca aaaccgatga cgaaaacacg ctgtatgtcg tgtataaaga 625921 ctccgccact gcctttaacg gcgagaaaaa agcagaaatc agcggaaaag ggcgcttaaa 625981 taatgaaatt tcaagcctca ttttcaaaca ccttcatgct aagggcatta acaatcattt 626041 tatcgagcgc atttcggaaa cggagcagct cattaaaaag gtaacgattg tgccgcttga 626101 agtcgtggta agaaatgttg tggcaggaag catgtccaaa cgtctcggca ttccagaagg 626161 cacggagctt gagcagccga ttatcgagtt ttactacaag gatgacgcgc tgggtgatcc 626221 gctcatcaca gaagatcata tttggctttt gaaggcggcg actcctgagc aggtagaaac 626281 cattaagtcc attacaacaa tagtaaatga agagcttcaa agcatcttcg acgattgtca 626341 tgtcagatta atagatttca agcttgaatt cggtttagat gcagaagggc aagtgctttt 626401 ggcggatgaa atatctcctg acacatgccg cttgtgggat aaagaaacga acgaaaagct 626461 ggacaaagat ttattcagac gcaatctggg aagcttaacc gacgcatacg aagagatttt 626521 caatagactg ggaggcattc atcatgtata aagtaaaagt ttatgtcagc ttaaaagaaa 626581 gtgtactaga tccacaaggg agcgctgtcc agcatgcctt gcacagtatg acttacaacg 626641 aagttcaaga tgtgcgcatc gggaaataca tggagcttac cattgaaaaa tctgaccgtg 626701 atcttgacgt gctagtgaaa gaaatgtgcg aaaaacttct tgcgaacaca gtgattgaag 626761 attatagata tgaggttgag gaggtagtcg cacagtgaaa tttgcggtga ttgtgttacc 626821 cggctccaac tgtgatatcg atatgtatca tgctgtaaag gatgagctcg gccatgaagt 626881 ggaatacgtc tggcatgagg aaacaagcct tgacggcttc gacggcgtgt taattccggg 626941 aggattttct tacggcgatt acttaagatg cggcgccatc gcccgatttg cgaatattat 627001 gccagctgtc aaacaagcag cggctgaagg aaaacctgtt cttggcgtct gtaacggatt 627061 ccagatttta caggagcttg ggctgctgcc aggcgcaatg agacgcaaca aagatctgaa 627121 gttcatttgc cgtccggttg aattgattgt tcagaacgac gaaaccttat tcacagcttc 627181 ctacgaaaag ggagaatcga ttacaatccc ggttgcccat ggtgaaggga atttctactg 627241 tgatgacgag acgcttgcta cattaaagga aaacaatcaa attgctttca catacggctc 627301 taatattaat ggaagtgtca gcgacattgc cggtgtcgtg aatgagaaag gcaatgtatt 627361 aggcatgatg cctcaccctg agcgcgcggt cgatgaactg cttggaagcg ccgacggtct 627421 taaattgttc cagtctatcg tgaaaaattg gagggaaact catgtcacta ctgcttgaac 627481 caagtaaaga acaaataaaa gaagagaaac tgtatcagca aatgggtgtc agtgatgatg 627541 agtttgcatt gatagaatcc attcttggaa gattgccgaa ctacacagaa atcggaattt 627601 tttctgtcat gtggtctgag cattgcagct ataaaaactc aaagccgatt ctgcgtaaat 627661 tcccgacaag cggcgagcgt gtgctgcagg ggccggggga aggcgccgga atcgttgata 627721 tcggtgataa ccaagcggtt gtgttcaaaa ttgaatcaca taaccaccca tcagctctcg 627781 agccttacca aggcgctgcg actggcgtag gcggaattat ccgtgatgta ttctcaatgg 627841 gtgcacgccc aatcgctgta ttgaactctc ttcgatttgg tgaactgact tcaccccgcg 627901 tgaagtactt gtttgaagaa gtagtagcgg gtatcgccgg atacggcaac tgtatcggca 627961 tcccgacagt cggcggagaa gtgcagtttg acagcagcta tgaaggaaat ccgctcgtca 628021 acgcaatgtg cgtcggttta atcaaccatg aagacatcaa aaaaggccag gcaaagggtg 628081 tcggcaacac agtaatgtac gtaggagcga aaacagggcg tgacggcatc cacggcgcta 628141 cgtttgcttc tgaagaaatg tcagactcgt ctgaagaaaa gcgttctgct gtccaagtcg 628201 gcgatccgtt tatggagaag cttttgcttg aagcatgtct ggaagtcatc caatgcgacg 628261 ccttagtcgg cattcaggat atgggagctg ccggtttaac aagctcaagt gcagaaatgg 628321 caagtaaagc cggttctggc attgaaatga atcttgacct gattcctcag cgcgaaacag 628381 gcatgaccgc gtatgaaatg atgctttctg aatcacaaga acggatgctt ttggttattg 628441 agcgcggacg tgagcaggaa atcatcgata tttttgacaa gtatgatctt gaagcggttt 628501 ctgtcggaca tgtgacagat gataaaatgc ttcgcctgac acataaagga gaggttgtgt 628561 gcgagctgcc tgttgatgcc ttggcagaag aagcaccggt ttaccataag ccttctcaag 628621 agcctgctta ctatcgcgag tttttggaaa cagacgttcc ggctccgcaa attgaagatg 628681 cgaatgaaat gctgaaggcc cttcttcagc agccgacgat tgcgagtaaa gagtgggttt 628741 atgatcagta tgactacatg gtgcgcacga atacagttgt cgctcctggg tctgatgctg 628801 gtgttctcag aatccgcgga acgaaaaagg cgctggcgat gacgacagac tgtaacgcgc 628861 gttatctcta tcttgatcct gaagtcggag ggaaaattgc tgtcgctgaa gcagcgcgca 628921 acatcatttg ctcaggcgca gaaccgcttg cggtgacaga taaccttaac ttcggaaacc 628981 ctgagaagcc ggaaatcttc tggcagatcg aaaaagcggc agacggcata agcgaagcgt 629041 gcaatgttct cagcactccg gttatcggcg gtaacgtatc gctttataac gaatcaaacg 629101 gcacggcgat ctatccgaca ccagttatcg gcatggtcgg cctaattgaa gatacagcgc 629161 acattacaac acagcatttc aaacaagcag gagatctcgt atacgtgatc ggcgaaacaa 629221 aaccagagtt tgccggaagc gagctgcaaa aaatgacaga aggccgtatt tacggcaaag 629281 cgccgcaaat cgatcttgat gtagagctgt ctcgtcaaaa agcactgctt gacgcgatta 629341 aaaaaggctt cgttcaatct gcgcatgatg tgtctgaagg cggcttaggc gtagcgattg 629401 cggaaagtgt catgacgacg gaaaaccttg gcgctaatgt gactgtagaa ggggaagcgg 629461 cgttattatt ctctgaatct caatctcgct tcgtcgtttc agtgaaaaaa gaacatcaag 629521 ctgcgtttga agcaactgtc aaagatgcag ttcatattgg tgaggtaaca gctgacggaa 629581 ttctggcgat tcaaaaccaa gacggacaac aaatgattca tgcgcaaacg aaagagcttg 629641 aacgcgtatg gaaaggagct atcccatgct tgctgaaatc aaaggcttaa atgaagaatg 629701 cggcgttttt gggatttggg gacatgaaga agccccgcaa atcacgtatt acggtctcca 629761 cagccttcag caccgaggac aggagggtgc tggcatcgta gcgactgacg gtgaaaagct 629821 gacggctcac aaaggccaag gtctgatcac tgaagtattt caaaacggcg aactcagcaa 629881 agtaaaggga aaaggcgcta tcgggcacgt tcggtacgca acggctggag gcggcggata 629941 cgaaaatgtt cagccgctcc tcttccgttc ccaaaacaac ggcagcctgg cgcttgctca 630001 taacggaaat cttgtcaacg ccactcagct gaagcagcag ctcgaaaatc aagggagcat 630061 ctttcaaacc tcttcggata cagaggtttt ggctcacctg atcaaaagaa gcggacactt 630121 cacgctgaag gatcaaatta aaaactcgct ttctatgctg aaaggcgcct acgcgttcct 630181 gatcatgacc gaaacagaaa tgattgtcgc acttgatcca aacgggctga gaccgctatc 630241 catcggcatg atgggcgacg cttatgtggt cgcatcagaa acatgcgcat ttgacgtcgt 630301 cggcgcaacg taccttcgcg aggtagagcc gggagaaatg ctgatcatta atgatgaagg 630361 catgaaatca gagcgttttt ccatgaatat caatcgttcc atttgcagca tggagtacat 630421 ttatttctcc agaccagaca gcaatattga cggtattaat gtgcacagtg cccgtaaaaa 630481 ccttgggaaa atgctggctc aggaatccgc agttgaagct gacgtcgtaa ccggggttcc 630541 ggattccagt atttcagcgg cgatcggcta tgcagaggca acaggcattc cgtatgagct 630601 tggcttaatc aaaaaccgtt atgttggcag aacgtttatt cagccgtccc aggctctgcg 630661 tgagcaaggc gtcagaatga agctgtctgc ggtgcgcggg gttgtagaag gcaaacgcgt 630721 cgtgatggtg gatgactcta tcgtgcgagg aacaactagc cgccggattg tcacgatgct 630781 aagagaagcg ggtgcgacag aggtgcatgt gaaaatcagt tcaccgccga tcgctcatcc 630841 gtgcttttac ggcattgaca cttccacaca tgaagaactg atcgcgtctt cgcattctgt 630901 tgaagaaatc cgtcaggaaa tcggagccga taccctctca tttttgagtg tggaagggct 630961 gctgaaaggc atcggcagaa aatacgatga ctcgaattgc ggacagtgtc tcgcttgctt 631021 tacaggaaaa tatccgactg aaatttacca ggatacagtg cttcctcacg taaaagaagc 631081 agtattaacc aaataaaact tgaaaaatga cataaaggca gcgcagttcg gctgcctttc 631141 tctttctgcc ctcgttcggg gagatatttt gaaaagcgcc ttaaaggagt gaataggatg 631201 tctgaagcat ataaaaacgc aggagttgac atcgaagccg gatatgaagc tgtaaaacga 631261 atgaaaaaac acgtggagcg cacgaaacgg cttggcgtta tgggcagcct tggcggtttt 631321 ggcggcatgt ttgacctgtc tgagctttct tatcaaaaac cagttctcat ttcgggaacg 631381 gacggtgtcg gcacaaaatt aaagctcgct ttttccatgg ataagcatga cacgattggc 631441 gtggatgctg ttgcaatgtg tgtcaatgac gtgctggcac aaggtgcaga gccgctgttt 631501 ttcctcgatt atttagcggt tggcaaagcg gacccagtga aaattgaaca gattgtacaa 631561 ggtgttgcgg aaggctgtga gcagtcaggt tcagccttag tcggcggtga aacggctgaa 631621 atgccggggc tctatacagc tgatgaatac gatattgccg gtttctcagt cggagtggca 631681 gaaaaggacg aaatcgtgac tggagaaaaa attgaagagg gccatctgtt gatcggcctc 631741 agctccagcg gccttcacag caacggcttt tcccttgtca gaaaagtgct tctggatgat 631801 gcggagctgg acctcgatac aacatatgag ccgtttgaac gcccgcttgg cgaggaattg 631861 cttgaaccga caaggattta cgtgaagcct gtgcttgccg cggtcaaaag cggaaaaatc 631921 gacggcatgg cgcacgtgac aggcggagga tttattgaaa atattccgcg tatgcttccg 631981 gaaggcttaa gtgcggaaat tgatcatggc tcatggccga tcccgccgat tttttctttc 632041 ttgcaagagt acggcaagct aaaggaagaa gacatgttca acgtctttaa tatgggtatc 632101 ggttttgttt tggcagtcaa agaagagcat ctgacagatg tgatcggaac gcttgaaagc 632161 catggcgaaa aagcctattt aatcgggcgt gtgaaaaaag gtgaaggcgt cacattcggc 632221 ggtgcggcac tttcatgaaa aagtttgcgg tatttgcatc aggaaacggt tcaaacttcg 632281 aagccatcgt cacgcgtttg aaggaggaga actgggatgc gtcagcagcg ctcctcgttt 632341 gcgacaaacc gcaggcgaaa gtcatcgaac gggcggaagc attccacatt ccatccttcg 632401 catttgagcc gaagtcttat gaaaacaagg ctgcatttga acaagccatc attgaacagc 632461 ttcgtcttca cgaggttgaa ttgattgctc ttgccggcta tatgaggctg atcggtgata 632521 cgctccttca agcatatggg ggaaaaatca ttaacattca cccatcgctt cttccggcgt 632581 ttcctggaat cgacgcagtc ggacaggcgt tccgggcggg tgtgaaggtg gccggaatca 632641 ccgtgcatta tgtcgatgaa ggaatggata caggtccgat catcgctcaa aaggcaatcg 632701 aaattgatga acatgataca ttggaaacaa tcgaacagcg aattcacaag cttgagcata 632761 aatggtatcc gagtgtgatt aaacagctat taggattaaa taacagaggt gaaaaggcat 632821 gaccattaaa cgtgcattaa tcagtgtttc agataaaaca aatctcgttc ctttcgtaaa 632881 agaactgaca gagcttggcg ttgaagtcat ctccacaggc ggaacgaaaa agcttcttca 632941 agaaaacggt gtggatgtga tcggaatttc tgaagtgaca ggctttcctg aaattatgga 633001 cggccggtta aaaaccctac acccgaatat tcacggcggc cttctggcgg ttcgcggcaa 633061 tgaagagcat atggcgcaga tcaatgaaca cgggattcag ccgattgacc tcgttgtcgt 633121 caacctctat ccatttaaag aaacgatttc taaagaagac gtcacgtatg aagaagcgat 633181 cgaaaatatc gacatcggcg gacctggcat gctgcgcgcg gcatcaaaga accatcagga 633241 tgtcacggtt atcgtcgatc cggccgatta cagcccagtg ctaaatcaaa tcaaagaaga 633301 aggcagcgta tctcttcaga aaaaacgcga gctcgcggca aaagtattcc gtcatactgc 633361 ggcatatgat gcactgatcg ctgactatct gacaaatgtt gtcggtgaaa aagaaccaga 633421 gcaattcact gtgacatttg agaaaaaaca atcgcttcgc tatggagaaa acccgcatca 633481 ggaagcaact ttctatcaaa cagctcttcc tgtcaaaggc tccattgcgc aagcagaaca 633541 gcttcacgga aaagagcttt cttacaacaa cattaaagac gcggatgctg cagttcaaat 633601 cgttcgtgaa ttcactgaac cggctgctgt tgctgtgaag catatgaacc cgtgcggcgt 633661 gggaacagga aaaacgatcg cagaagcgtt tgacagagcg tttgaagcgg ataaaacatc 633721 tatcttcggc ggcattatcg cgctgaaccg tgaagtggac aaggcaactg ccgaagcgct 633781 tcacaacatt ttcttagaaa tcatcattgc gccttcattc agccaagaag cgctcgacgt 633841 cctgactgcg aagaaaaatc tccgtctgct gacgcttgac gtatccgccg ctgttcaaaa 633901 ggaaaaacag ctgacatccg ttcaaggcgg gctgctgatt caagatttag atatgcacgg 633961 cttcgatgat gctgagatta gcattccgac aaaaagagag ccgaacgagc aagagtggga 634021 agacttgaag cttgcttgga aagtcgtgaa gcatgtgaaa tcaaatgcga ttgttctcgc 634081 gaaggacaac atgacagtcg gcgtgggagc aggccaaatg aaccgcgtcg gatcggcaaa 634141 aatcgcaatc gagcaagcag gggaaaaagc gaagggcagc gcgctcggtt cggatgcata 634201 tttcccaatg ccagatactg tcgaagaagc ggcaaaagcg ggcgttacag ccatcattca 634261 gccaggcgga tcgatccgag atgaggattc catcaaaaaa gcggatgaat acggcattgc 634321 catggtattc accggcatca gacacttcaa acattaaggg gatgaaaacg acgtgaatgt 634381 attaattatc ggtaaaggcg gaagagaaca tacgctggcg tggaaggcag cgcaaagcag 634441 cctcgtcgag aatgtatttg ccgctcccgg aaatgacggc atggcagctt ccgctcagct 634501 tgtaaacatt gaggaaagcg accacgcagg gcttgtctca tttgcaaaac aaaatcaggt 634561 cggcctgacc attgtcggcc ctgaggttcc tttaattgaa ggtctggtgg atgaattcga 634621 aaaagcgggc ttacatgtgt tcggtccgtc aaaagctgcg gcgatcatcg aaggaagcaa 634681 acagttcgct aaggatttaa tgaagaaata cgacattccg accgcagaat acgagacgtt 634741 tacatccttt gatgaggcga aggcatatgt gcaggaaaaa ggtgctccga ttgtgataaa 634801 agcagatgga cttgcagctg gaaaaggcgt tactgtggct atgacagagg aagaagcaat 634861 tgcgtgcttg catgactttc ttgaagatga aaagttcggt gatgcgagcg cgtccgttgt 634921 cattgaagaa tatctttctg gtgaagaatt ttctctaatg gcctttgtca aaggggaaaa 634981 ggtgtatccg atggtgattg cccaggatca caagcgggcg tttgacggag acaaaggccc 635041 gaatacaggc ggcatgggcg cctactcgcc agttccgcaa atttcggaag aaacggtccg 635101 ccatgctgta gaaacgatcg ttaagccggc tgcaaaagca atggtacaag aaggccgttc 635161 cttcactggc gttttgtacg ctggattgat gcttactgaa aacggctcga aggtcattga 635221 atttaatgcc cgtttcggcg atccggaaac acaggtcgtg cttccgcgca tggaatctga 635281 tctggtacag gtgcttcttg atcttttaga tgataaggaa gttgacttaa gatggaagga 635341 taccgcggca gtgagtgttg tgcttgcatc agaagggtat ccggaaagct atgcaaaagg 635401 cacgccgatc ggcagccttg cagcagaaac tgagcaggtc gtggtcttcc atgccggaac 635461 gaaagcagaa ggtggagagt tcgttacaaa cggggggcgc gtcgccaatg tgacggcttt 635521 tgatgaaacg tttgaagcgg ctagagaccg agtgtacaaa gcggttgatg aaattttcaa 635581 accgggactc tttttcagaa aagacattgg ggcacgcgct ttaaaggctg cccaaaaata 635641 agtgaggaaa acccgcagaa tagctgcggg ttttttgtta tcaaaaagcg ggatggcagc 635701 tagaagaaga aagcacaacg agcgtggttg gttttccatg ggccatcgag gtgtcaataa 635761 aatcctcaag cgtatgtacc gattcagtca cgacctttgt cacatagctg tacatccccg 635821 tgatgcggtg gttttctgct acatcaggat gcgatgttgc aaaggcggcg tagtgcttgc 635881 agcttttcgg ctccatgaga ataaaagcgg tgacatgctt gtttagtttt tcgtaacaga 635941 tattcgcgct gtagccggta atcactcctt tgtcttccag cttcctgaca cgctccgccg 636001 cgcttggcga gctgagtccg acaagctttc ccagctcaac catcgttaat ctgccgtttc 636061 gctgcaaatg cgagagaatc tgaaggtctg tatcgtccat ttgtctggct cctttacata 636121 tttaggcgaa tgaatgaaaa ttcctttgat cgtaaggtaa tgctgttgat ttaacttcat 636181 tgtagcatat ggatgccgtc ttattttttc tataataaag ccatcaatca gagagggggc 636241 atcatgttgc cagaattgca gcgctctatt acttggatac aagggacggc gttaacgatt 636301 ggggcggttt taggatgcgg gatattaatc ctgccgtctg tcaccgcgga cacggccggc 636361 cccgcttctt tatttgtttg ggtgttcatg tccttcttat ccttttttct tgtcggcacg 636421 ctggcccggc ttgtgaaaat agcgcctagc gcgggaggaa tcacggctta tgtgcagctg 636481 gcctttcaga aaaaagccgg ggctattttg ggctggatca tgttagggtc cgttccgatc 636541 ggcgttccca tcatcgcttt gactggcgcg cattacgtca gttacatcac agaggcggcc 636601 gattggcaga ttacattgat tgctggttgc atgctggcta tatctatttt gcttcatatg 636661 agagggattc aactatcagc aaacattagt acactcgtta tatgtgtcat cgtatttctg 636721 cttgtcactt ctattgctgt gtcattgcca cacgtcacga tagcagaatt caagccgttt 636781 cttccgcatg gctggtctgc cgctggatct gtttctgtta tgattttttt ctcttttgta 636841 ggctgggaaa tgattacccc gttggctgag gaatttcatc gtcctgaaaa agatgtcccg 636901 ctcagcttgt ttttggcagc gtcttgtgtg gcggggctgt atatcatgct gtcatttgtg 636961 accgtgggta ctcattcata tggagagaat ggagaaattg catcgcttgc catgctcatt 637021 tcaaaaggag caggagaaag cggtgtatat gtcacggtat gtttagcgct gtttattaca 637081 ttcgccacca tccatgccaa tattgccggt ttttcaagaa tggtgtacgc attggcgaga 637141 gaggggcaca tacccgtatt ttttggaaaa ctcagtgcga caaaacgtac gcctattcgc 637201 gttttgacag cgatggccgc agtgtttggc ttagtgcttg cagcgcatgg tctgtttcaa 637261 atcgatttga cgactctgtt gaaagggccg agcgcggctt ttatcgcatc ttacatatgt 637321 acaatggcgg cagcactgaa actgctgggc aggagagata taggctggtg gatggcgctc 637381 ggggcatttg tggcgtgcgc ggtgatttat tcattcagcg gctgggcact gctttatccg 637441 gcagtgctgg cagctgcagg atatttctat atgaaaacaa agggtgggca taaaaaaaag 637501 cttgatcacg ttttgtgatc aagcttttcc atttatccgt tttgatgctc gttatttcca 637561 gaatcgctgt gttgaaacat gtaggtcaca ggacagaagc gcaagattcc cgaacccgct 637621 ttcatggccc ccataaagat gtaaaagaga tgcattctgc accaaggttt tttcgtaaac 637681 tttgcactgg cggctgacat aatcgtcaat ccgcaggcga ttctgaacac ggcattgatg 637741 agactgatgt ttggcttcaa ggaaatccgc tccttttact taaaaaagtt ttttaatcga 637801 accttcaaaa atttgtaacg tttttatcgt gcgtgatgag gaaggatgtg ataccatgag 637861 tctaatacat gtaaaggaga gtatgtgaat gtccgaacgc acctttaact ggaaaaacaa 637921 agacatcagg gcacaggttg atgttgtaga ctcaaagctg cttccaacgc tccttttacg 637981 gaatgctctc gtcttaaatc catatgtaaa acaatggctg aaaaaaaaca tttggattta 638041 tcaggaccgc attgtttatg tgggtcatga acttccgaat agagccgaag aaattcatac 638101 gattgattgt gaaggaaaat acattgtgcc aggttatatt gaaccgcacg cacatccttt 638161 tcaaatatat aatccccaaa cactggcgga atatgtgtct caatacggaa caacgacatt 638221 cgtgaatgat aacttatttt tgcttttgca aagcggaaaa aagaaagcgc ttacgatttt 638281 gaatgaactc aaaaagcagc ctgtccagta tttttggtgg tcacgctatg acctccagac 638341 cgaggttctg aacgaggacc acgtccttcc atttgacgtc agaaaacagt ggattgaaca 638401 tccggatgtg attcaaggcg gagaaatgac cggatggcct cgcctggtag atggtgatga 638461 tttaatgctc cactgtatgc aagctacaaa gaaacagaga aaacgtattg aagggcattt 638521 tcccggcgct tctgataaaa cgcttacaaa aatgaagctg ttcggtgcgg attgtgatca 638581 tgaagcgatg acaggtgatg aagtgatgag aaggctggaa ctgggctatt atgtttccct 638641 tcggaactct tccattcgcc ccgatgtaag aaaaatcttg caagagctgc atgagaaggg 638701 cttccgctat tatgaccact tcttttacac gacagatggc gcaaccccga atttctataa 638761 aggcggcatg acaaacgagc tgattcgcat tgcgttagaa gaaggcgtac ctgcaatcga 638821 cgcctacaat atggcatcat ttaatatcgc aaagtattac caaatggatg attatttagg 638881 agttgtcgga ccgggcagac tggcatcgct aaacatactg gaagatccgt taaatccgaa 638941 tccagtgact gttctgtcaa aagggaccat tctgcgtgaa aacggctgtg atttgaaggc 639001 gtttacaaag acggactggc acaaaggcgg tcttgtcccg cttgagcttt catatgatat 639061 gacgatggat gacttgcagt tttctatgcc gatgggcgtg aaaatgcgga atgcggttat 639121 tatggagcca tatatgattg agatcgacaa ttcgatggaa cagctctcgt ttgaccatga 639181 tgaaagttat ttgacgatgc tcgacagaca cgggaaatgg cgcgtcaata cgatgataaa 639241 agggtttgcc tcaagcgtgc agggatttgt aagctccttt acgacgacgg gcgacattgt 639301 cgcgattgga aaaaataaag cggatatgct gctcgctttc gcccgcatga aagaaatcgg 639361 aggaggaatt gttttagcgg agaacggaaa cattctgcat gaaatcccgc ttgcgctgtg 639421 cggctgcgcc tcttcggaag cgtatgaaga cgtgcttgag aaggaacaaa agctgagaga 639481 tcttttgact gaaagaggct atgagttttg cgatcctatc tatacgctgc tctttttgca 639541 aagtacgcac cttccgtata tacgcattac gccaagagga atattcgacg tcatgaaaaa 639601 aactgtactc tttccatcga taatgcgtta aaatataaaa gagcagggag ccgacatatg 639661 aaaaaatgga tgacagtttg cgcgctgtgt ttcgtgtttt ttctgctggt atcctgccag 639721 cagaaggatg ctgtcccgga tactgcaaag aagctgaaag ctcctttaac ggggctaaag 639781 actgaacaga aagtgactga acgccgccct gttgctgttg tggtgaacaa tcacccgaag 639841 gcgaggccgc agtcgggtct gtctaaagcc gacattgtca tagaagcgct agccgaaggg 639901 caaatcacaa gatttctggc cattttccaa agccagatgc ctgaaactgt cggacctgtg 639961 cggagcgcgc gggaatattt cgtcactctc agcaatggct ttgacagcat atttgtccat 640021 cacggctgga gtcccggcgc caaaaagcag ctggaatccg gagctgccga ttatatgaac 640081 ggattggatt ttgacggaag cttattttgg agagctgatt tcagcaaacc gccccacaat 640141 tcctatacgt cttatgatta cataaaaaag gcggcagaac aaaagggtta taagctgaag 640201 caggaaacaa atccgctgct gtttcaaaca tcagatgcaa aacctgcaaa tgaatcttac 640261 aatgttcggg tagattatgg aacaaataac gttacaaatc ttgtcgaata caactatgat 640321 aaaaaagctg aattttatac aagaagctct gatggtgtca taacgacaga ccgggaaacc 640381 ggaaagccgg ttgcaatgca aaatattttc attgttgaag ccagccatca tattattgat 640441 caagatggaa ggcgggacat cgacttggaa tcaggaggaa aaggtctgtt gtttcagcac 640501 ggaaacgtca ttgaaacaga ctggaaacaa gtgaatggca gaattgtgcc ggtaaaagac 640561 ggcaagtggc ttccgtttgt gccaggaaag acttggatca atatcgtacc tgatcttgat 640621 gcggcttcca ttagtaaagg agaaggtgtg taacgatgca aatcgataaa ttacgcggca 640681 aagagctgga ccagttattt aactcgatct tatcgctgaa agacctggag gaatgttacc 640741 gattcttcga tgatctatgc acaattaacg aaattcaatc gctggctcag cgccttgaag 640801 tggcgcgcat gcttcgcgaa ggaaacacgt atcataagat tgaaacagaa acaggcgctt 640861 ccacggctac gatttcccgt gtgaaacgct gcttaaatta cggaaatgac gcttatgaaa 640921 tggcgcttga ccgtgtgaag gagacggaaa cagagtcttc ttccaaataa aaaaccgccc 640981 tgccgtctgg caagggcggt ttctttatga aacaaattga tggatcaggt tgtcgatatt 641041 gatgatactg ccatcctctt tccgatagac aacatgctcc ttggaaaaat gaatcggcga 641101 attaatccct gctgcggctg caaggttaaa tagtccctcg cgcaatgaaa taacgtagtt 641161 gcagacacga tgctgttttt cctcaacgct cagtgctttt tgcaatttcg gatctgtcgt 641221 cgccacacct gccggacagg tgttggtgtg gcagacgaga gcgcggatgc agccaacgga 641281 aaacatcatg ccgcgtgcga tgttaacaaa gtcagcgccg agggctaagg cgaccgcgat 641341 tttatcagga gtcaggagct ttccggaagc aaagattttc agctggctgc gcaagccgta 641401 ctgtttaaga agcgtgtcca caataggcag cgctgtcata atcggaaggc cgactgtatc 641461 cgcgagctcg taaaaggaag ctccggtacc gccttcactt ccgtcgatcg tgataaaatc 641521 cggatgcttt ccgcttttct gcatatgaga gaaaagctca tgcaattctt caggatgccc 641581 tgcgaccagt ttgatgccga ctggcttttg tccgacatct ctaagttttt caataaagtc 641641 gagcatttca ggagggtttg agaattcata aaagcggttc gggctgtcaa tcgactttcc 641701 aggttcgaca ttccgaatgt ctgccacttc ctctgatact ttggcgccgt ccacatggcc 641761 gccgcgggtt ttcgctcctt gtgccagctt tagctcaaac gctttaatct ggtcaatcct 641821 gctttttctt ttaaattcct cccacgaaaa ttccccgttt cttttgcgca cgccgaatag 641881 gcccggtccg atttggcaaa tgatatcggc gccgcccttt aagtgatatt cagacaatcc 641941 cccttcacct gtattcatcc aggtgccgcc tgccagatgg agcccttttg agagcgccgt 642001 aacagcccgt tctccaagag aaccgtagct catggcagac tggccgacta agcccttcac 642061 ataaaatggc ttctcgcatg tatgctcgcc aatcacctgt acatcatcag gatggagaaa 642121 atacgggtct gccttgatat gttcggcatg ctccttgcgt ttgaacagat tgtcagcatc 642181 cattttatag atttgggttt caatttttgg cgtttgattt acatgcattt cttccctttg 642241 ttttggaaac atagcgttac ggatataata gccaggttta tcaaaatctc ttacagatcc 642301 aaagcccatc attctgcttt tgtatttgcc ggagatgacg gtttgctcat attcctttcg 642361 tgaaaatggc tgctcttcat tgtcattgct gtataaatac tgtctgagct ccggcccgat 642421 tttttcaagg atataccgaa accttccgat gacgggatag ttgcgaagaa ttgagtgctc 642481 ctgctgtttt tcatccttta tgtagatcca ggcaaacaag acgatcggga tagcgatgat 642541 cccaatgata aatgcgatga gtgctattat gatggtttcc atctctcagc ctcccttttt 642601 atgtaaccat ttccacagta gaacactttc caaacaatag cagaaggaat ctggtgaaaa 642661 atgtgtgctc ctgccgatac aggactcacc atgcaggtac tgccatatgc tctctttttt 642721 tatgaaaaaa gaatcaaaac acctttttca gtgaataacg agattaacgg ctttttccgt 642781 ttttccgcgc tatgtgaatt tgttataatg tttaaatggt aacaaacgaa tggaggaacg 642841 tatgacgtgt acgatgtaac ggagtggaag catgtcttta aactcgatcc aaataaagat 642901 ttgcctgacg aacagctgga gattctttgc gaatcaggaa cggatgcggt cattatcgga 642961 ggaagcgatg gtgtgacaga ggataatgtc ctgcggatga tgtctaaggt aagacggttt 643021 ttggtgccgt gtgtcctaga ggtatcagcg attgaagcga ttgttcccgg ctttgactta 643081 tattttattc cgagtgtatt aaacagcaaa aacgcggatt ggattgtcgg aatgcaccag 643141 aaagccatga aggaatacgg agaactgatg tctatggaag aaatcgtggc ggagggctac 643201 tgcatcgcaa atccagattg caaagccgcg gcactgactg aagcggacgc cgatctgaat 643261 atggatgata ttgtcgccta tgcgcgtgtg tcggagctgc tgcaactgcc gattttttat 643321 ttagaataca gcggcgtgct tggagacata gaagctgtca agaaaacgaa ggctgtattg 643381 gaaacgtcca ccttgtttta cggcggcggc atcaaggatg cggaaacggc caagcagtac 643441 gcagagcatg cggacgtgat cgttgtaggc aatgcggtgt atgaagattt tgacagggct 643501 ttgaaaacag tagcggctgt gaaaggcgag tagtaaattg tacggatttg gtttatgata 643561 gaacgtatgt tttgtatagg cgggtgaaca aattttgaat tatattagca atcaattact 643621 aagcggttta aaccccgttc agcaggaagc agtcaaaaca acggacgggc ctcttttgct 643681 gatggcggga gcgggtagcg gaaagacgcg tgtcctgacc catagaattg cttatttaat 643741 ggcagaaaag catgtggcgc cgtggaacat tctggcgatc acatttacaa ataaagcggc 643801 acgcgaaatg aaagaacgtg tggaaagcat cctcggaccc ggcgcggacg atatctggat 643861 ctccacattc cacagcatgt gcgtgcggat cttgcgcaga gatatcgacc ggattgggat 643921 caaccgaaat ttctccatcc ttgatacggc tgaccagctt tcagtgatca aggggatttt 643981 gaaggagcgc aatcttgatc cgaagaagtt tgacccgaga agcatcctcg gcacgatcag 644041 cagtgcaaaa aacgaattga ccgaaccgga ggaattctct aaagttgctg gcggctacta 644101 cgatcaggtg gtcagcgatg tatatgctga ttatcagaag aagctattga aaaaccagtc 644161 gctcgatttc gacgatttaa ttatgacgac gattaaactg tttgacagag tgcctgaagt 644221 gcttgaattt tatcagcgca aattccagta catccacgtt gatgagtatc aggatacgaa 644281 cagggcacaa tacatgctcg ttaagcagct tgccgagcgt ttccagaacc tttgcgttgt 644341 gggggattct gatcagtcaa tctacagatg gcgcggcgcg gatatcacca acattctttc 644401 atttgaaaaa gattatccga atgcaagcgt gattttgcta gaacaaaact atcgttcaac 644461 gaaacggatt ttgcgcgcgg ctaacgaggt cattaaaaac aactctaacc gcaaaccgaa 644521 aaatttgtgg acggaaaatg atgaaggcat caagatttcc tattatcgcg gtgataatga 644581 gttcggtgaa ggacagtttg tggccggcaa aattcatcag cttcacagca caggcaagcg 644641 gaagctgtcg gatatcgcca tattataccg gacaaacgcg cagtcccgtg tgattgagga 644701 aacgcttctc aaagcgggct tgaactataa cattgtcggc ggcacaaagt tctatgacag 644761 aaaagaaatt aaagacattc ttgcgtacct gcgcctcgta tccaatccgg atgacgatat 644821 cagtttcacg cgcattgtca atgtgccgaa gcgcggagtc ggcgcgacat cacttgaaaa 644881 aatcgcttcg tatgcggcca taaacggctt gtcctttttc caagcgattc agcaggttga 644941 ttttatcggc gtcagtgcca aagcggcaaa cgcgcttgac agctttagac agatgattga 645001 aaacctgacc aatatgcagg attacttatc cattacagag ctgacagaag aaattcttga 645061 taagacggaa tacagagaaa tgctgaaggc tgagaaatcg atcgaagccc aaagccgttt 645121 agaaaatatc gacgagttcc tgtctgttac gaaaaacttt gaacagaaaa gtgaagacaa 645181 gacactcgtt gcgttcctga cagacttggc attgatcgca gatattgatc agctcgatca 645241 gaaggaggaa gagtcaggcg gcaaggatgc gatcaccctg atgacactgc acgccgcgaa 645301 aggactggag tttccggttg ttttcttgat ggggcttgaa gaaggcgtct tcccgcatag 645361 ccgttcactc atggaggaag cggaaatgga agaagaacgc cgccttgcgt acgttgggat 645421 tacaagggcg gaacaggagc tttatctgac caatgctaaa atgcgcacct tgtttggccg 645481 gacaaatatg aacccggaat ctcgcttcat tgctgaaata ccggatgatt tattggaaaa 645541 cctaaatgag aaaaaagaaa caagagcgac gtctgcgaga aaaatgcagc cgagacgcgg 645601 ccctgtttca cgcccggtat cctacgccag caaaacaggc ggcgacacct tgaactgggc 645661 agtcggagat aaggcgggcc ataaaaaatg gggaacagga actgtcgtca gcgtgaaagg 645721 cgaaggagaa gggacagagc ttgatattgc cttcccgagc cctgtcggcg tgaaacgcct 645781 gttagcagca tttgctccta ttgaaaagca gtaattgaag aggaaaggaa gaagcagatg 645841 gacaaagaaa cagcgaagca gcgggcagaa gaactgcgcc gcaccatcaa caagtatagc 645901 tatgaatatt acaccttaga tgaaccgagc gtcccagatg ccgaatacga cagattgatg 645961 caggagctga tcgcgatcga ggaggagcac ccagacctca gaacgcctga ctctcctacg 646021 cagcgcgtcg gcggagccgt gcttgaagcg tttcagaaag tcacccacgg cacaccgatg 646081 ctcagtctgg gcaacgcctt taatgctgat gatcttcgtg atttcgaccg ccgtgtgcgc 646141 cagtccgtcg gcgacgatgt ggcgtataat gtggagctga aaatagacgg tcttgctgtt 646201 tctctccgtt atgaagacgg ctattttgtc agaggggcca caagaggtga cgggacgacg 646261 ggagaggata tcacggagaa tctgaagacg atccgcaata tcccccttaa aatgaaccgt 646321 gagctgtcga tcgaagtgcg cggcgaggcg tatatgccga agcgttcgtt tgaagcactc 646381 aatgaggaac ggattaaaaa tgaggaagaa ccgttcgcca atccgcgaaa tgccgcggcg 646441 ggatctctca gacagctcga tccgaaaatt gcagcgaaac gaaacctcga tatcttcgtc 646501 tacagtatag cggagcttga cgagatgggt gtagagacgc aaagccaagg gcttgatttt 646561 ctcgacgaac tcggatttaa aacgaatcag gaacgaaaaa aatgcggcag catagaagaa 646621 gtcattacgc tgatcgatga gcttcaggcg aagcgcgcgg acctgccgta cgaaatagac 646681 ggcattgtca ttaaagtcga ttctctcgat caacaggagg agctcggttt tacggcgaaa 646741 agcccgcgct gggccatcgc gtataagttt cctgctgaag aggtcgtgac gaagcttctc 646801 gatatcgaat taaatgtcgg cagaacgggt gtgattacgc cgactgcgat tcttgagccg 646861 gtaaaagttg ccggcacaac ggtctcaaga gcatcccttc ataacgaaga tttaattaaa 646921 gagaaggaca ttcggatttt ggataaggtt gtcgtcaaaa aagcgggcga tatcatcccg 646981 gaagttgtga atgtcctcgt tgaccagcgc acaggagaag aaaaggaatt cagcatgccg 647041 acggaatgtc ctgaatgcgg cagtgaactc gtccggatcg aaggagaagt ggcgcttcgc 647101 tgcattaacc ctgaatgtcc ggcgcaaatc cgggaagggc ttatccattt cgtttcccgg 647161 aatgccatga acattgatgg gctcggcgaa cgagtgatca cacagctgtt tgaggaaaac 647221 cttgtccgca atgtggcaga tttatataag ctgacgaagg aacgagtcat ccagctcgag 647281 cgcatgggcg aaaagtccac tgaaaacctg atcagctcca tccaaaaatc aaaagaaaat 647341 tcgttagagc gcctgctgtt tgggcttggc atccgtttta tcggatcaaa ggccgcaaag 647401 acgcttgcca tgcattttga aagcttggag aacctgaaaa aagcctctaa agaggaactt 647461 ctcgcggtag atgaaatcgg tgaaaaaatg gctgatgctg tgatcaccta ttttcataaa 647521 gaagaaatgc ttgaactctt gaatgaactt caggagctgg gcgtaaacac gctctacaaa 647581 ggcccgaaaa aagtaaaagc agaggacagc gactcttact ttgctggtaa aacaattgtt 647641 ctgacaggaa agctggaaga gctgtcaaga aacgaagcca aagcgcaaat cgaagcgctg 647701 ggcggaaagc tgactggaag cgtcagcaaa aacacagact tagtcatcgc cggagaagcg 647761 gcgggaagca agctgacaaa agcacaagag ctgaacattg aagtgtggaa tgaagaacag 647821 ttaatgggag agctaaagaa ataagaggag tgttttctat tgaaaaagac gttggcattg 647881 gcggcaacgg cggcagtatt aatgctgtct gcctgctcgt caggtttcgg gggggagaag 647941 gaggaagaga ttacgcaaaa gacggcgaaa tcgtcagaaa aagcgattgt cccgaaatat 648001 aatatctctg actcctatta caaaatggtg ctgccgttta aggcaggcaa agcgcgcggc 648061 ttaacaacgg aacagctgaa tacaaggctg gacattgacg aatttgaaac agggctgatg 648121 cgccttgccc aagattcttt ctcaactgac gattatctgt tccaagaagg acaatattta 648181 gatgaggata cagtattaag ctggctggca cggaaaaaaa cgggctctga tttgaaaaaa 648241 gccgaaaaag aagataagaa cttcaaaaat gaaggcttga acccggcgct cccgagttct 648301 ggttcaacag aagaaaagaa cgaaagcagc ccaatttatt tagcatccat gcttgagcac 648361 gattatttag tcagaaaaga caagaattct atccagcttg gcggcgtcat gatcggactg 648421 gcgttaaact cagtgtatta ctatcgtgaa aaaactggcg acccgcaaaa agaagtggag 648481 attaaagaca gcacgcttcg ccagcaggga gaaaaaattg cacaggaggt tattaaccgc 648541 ctccgcaaaa aagataactt gaagaatgtg ccgattaccg tggcgctcta caagcaggcg 648601 tcaaaaacat cgattgtgcc ggggaacttc atcgccaaaa cagaggtcaa agcaggctct 648661 actgatatct caaattggga tgacatcaat gaaaaatatg tattctatcc ggcggataca 648721 accacagcag aaaagtaccc ggatgacacc gaggtcttta agcggttcaa aaactcaatt 648781 gaagaatatt tcccgaacta tacaggcgtt gtcggtacag cgctgtatga aaatgatgaa 648841 atgaagaaaa tgaagattga cataccaatg caattctacg gaaaaagtga agttgtcgcg 648901 tttacccagt tcttaacggg tgaagtgatg gactactact ctaagagctc agttgatgtc 648961 gaagtcaata tcacgtcctc agacggacag gaagcggtca ttatccgcaa tgccggagat 649021 aaagagccga ctgttcacat ttatgactga tagaaaaccc ttgtgccata ttggcacaag 649081 ggtttttatg ttacaattaa caggaaaagg gaaaatattt tcacttctgc cgaaacacaa 649141 atcaagggga ggtatgttga tgctggaaat cgtgtgaaaa caatcattat caaatctata 649201 gcaatgaaag gatgttagac gtgcataaag atatcaaaaa aatatttcat gaagagcagg 649261 ttttggcaga agctgcagcg agatacggtt tctcaaaaga tcaggtgcgt tttctggctg 649321 atgcggaaaa ctatgtatat gaatgtatga aagacaatca accttatatt ttaaagatta 649381 cccatacgat tcggagatct tctgattata tgatgggaga gatggaatgg ctccgtcacc 649441 ttgcaatagg gggaatttca gtagccaaac cgctcccgtc gctgaacgga aaagacgtag 649501 aagcagtgcc ggacggaaac ggcgggtcat ttttattgag agtgtatgag aaagcgccgg 649561 ggcaaaaagt ggatgaatcg gactggaatg aaacgctatt ttatgagctt ggcagataca 649621 caggcagcat gcacagcctg acaaaaagct acaaattgag caatcccgct ttcaaaagac 649681 aggaatggga tgaagaggag caattaaagc tgagaaaata tgtgcctgaa gatcagataa 649741 aggtgtttca gcaagccgat tctttgatga atgaactgcg gaggctcccg aaaagccagg 649801 acaactacgg cttggtgcat gcggatctgc accatggcaa ttttaactgg gatcatggca 649861 aaatcacggc atttgatttt gatgatatcg gctacaactg gtttgttaac gatattagca 649921 ttcttctcta caatgtcctg tggtatcctg ttgtgccata tgatgataaa gctgcgttta 649981 cagaagaatt tatgacgcat tttatgaaag ggtactggga ggaaaatgag cttgaccctg 650041 catggctgat gataatacct gatttcctcc gccttcgcca tatgctgatt tacggattgc 650101 tgcatcagat gtttgacctt aacacaatag gagaagagga aaaagaaatg ctggccggtt 650161 tcagaagaga tatagagaat ggcacgccga ttacagcatt tgatttttca gcactggtgt 650221 agatagaaaa agccaatggg attccagtcc cattggcttt tataatgtat cacacttcac 650281 gccgactacg ccttcaatgg ctttaatgtc atagtagaca tcggtcgtgt atctgttttt 650341 atggacgcgg accttcactt ccataattgg aaaatccttt tcgcctaggt cgtcgatccg 650401 aacggagtgt gctttgatat ctcttctttt catttctttt aaaatctctg tcattttgtc 650461 tttatcagaa agtgacattc tgatgcggat gtctttttcc tgcaggcggt cggggccgat 650521 ttttctgacc acccatggga gaaattccac actgatcagg atgaacagaa gactggcaaa 650581 cgcttcttta taaaaaccgg ctcccgtagc aagcccgagc cccgctgccc cccagatcat 650641 ggccgatgtc gtcaggccgg aaatgacatc attgcttttt cgcaggatga caccggcgcc 650701 gataaacccg acgccggaga tgatttgtgc cggcagacga agcggatcca tcatgatgcg 650761 gtagtattta gggaaatgat atgccgcatt aatactgacg atcgtcagca tgcatgagct 650821 gactgcgatg acaatacagg tttttaatcc gagcggctta ttttttaatt cgcgttcaag 650881 cccgatgacc atgccaatca atgtggcaat gcccaatttc aataaaatat caggatcaat 650941 ataccagctc aacagcaaac ttcccccttc tctatggtgt ttttaaataa atatgatttt 651001 ctcacagtat ttatagcaaa acaagagcac aaaagccacc aagctgcgct tgatggctta 651061 ttgcttactt tttgcgtttt aacagctttt ccatgacacc gaataatcgg taagaggctt 651121 ttgcaggacg ttttgtgatc atgctgacaa tgatgccggc aatcatactg agaataaacc 651181 cagggatgat ttcgtacaca ccggttgatt ttgccaggcc ggttgtaatc cagatcaaca 651241 cggtcgcagc cccgacaatc atggcagcaa gcgcgcccca ttcgttcatt cgtttccaat 651301 acagactgag cagaatcgca ggcccgaaag ctgaaccgaa gccggcccaa gcgtatccga 651361 ccaaatcaag aatggtgctg ttcgggttca atgacaagag taccgcgata acggcaatga 651421 ctaagacgga caatcgcccg atcatgacca attctttatc agaagctttt cgtctgaaaa 651481 atgaccggta taaatcctct gttacagcac ttgctgtgac caagagctgt gaggaaatcg 651541 aactcatgat ggcagccaaa atagctgaca ataagaaccc tgtaattaat gggtggaaca 651601 agattttaga gaagataatg aaaatcatct ccggatcttt tacagcaact ccgaatttat 651661 gggcgtatgc aacaccgatt aaacccgtca gcacggaacc tagaactgta atgatcatcc 651721 agctcatgcc gattcggcgt gcaggtttta aatctttaat gtctttaatg gccataaatc 651781 ggacgatgat atgaggctgg ccgtagtagc ccaaccccca ggctaaatag gaaataatgc 651841 taatgacgct cgcgccttta aaaatatcca ataaatgtgg attaacagcg tcgatttcat 651901 ggaaagtcgg agcaacgccg cccacatggg taaaagcaac gatcggcaca agcactagtg 651961 ctgcaaacat gatcgcaccc tgcacgaagt cagtcagact gacagcaagg aaaccgccaa 652021 acagtgtgta taacacgaca actgcggtgg tcagaaacag gcctaatttg taatccgcac 652081 caaaagcaga ttcaaacagc cgtccgccag ataccatacc ggaagaggta tacaatgtga 652141 aaaagatcat gatgatcaat gcagatacga ttttcagcag tgatgaagaa tgctggaatc 652201 gtttatcaaa gaaatcagga attgtaatcg catcatctgc cgcttctgta taagcacgca 652261 gccttggagc cagcagcaag taatttgagt acgccccgat tgtaagacct aaagcaagcc 652321 ataaggtgga cagccctgtc gcaaacatcg cgccgggaac acccatcagc atccatccgc 652381 tcatatcggc cgcgccggca gacaaagcag taacgaatgg tccgaggcct cttcctccaa 652441 gcatgtaatc attgatgtca gtggttttct tgaatgcata ccagccgatt aacagcatgg 652501 caataaagta aattcctaaa gatataataa tttcaatact cacgttttac cctctcttca 652561 tttctaataa tgttgcatca cctctcaaat tgatggtgcc agttaagcag cctggcgtaa 652621 gtgcaaaaca aaagaaattc ttttgcgggt gcacttggta acttaaccta acaaagtatt 652681 cccggccatt caagcgatga aacattgatc ataagctgga aataccgttg caaacctaga 652741 agggaataaa gaataaaacg ctttcaaaaa ataattaaag taaaaatatt cagaaaaata 652801 tttcgtttct ccttctcctc attttagtat aaaatatata gggtattgtt tcgaaaacac 652861 aggcctgtct caaggcgttt tgttgcttta aagggcttgt ttttgatatg atcagtatta 652921 tatgacttaa cggagaaata tgtggaggtg gatcatatgt cacgaatttc aatagaagaa 652981 gtaaagcacg ttgcgcacct tgcaagactt gcgattactg aagaagaagc aaaaatgttc 653041 actgaacagc tcgacagtat catttcattt gccgaggagc ttaatgaggt taacacagac 653101 aatgtggagc ctacaactca cgtgctgaaa atgaaaaatg tcatgagaga agatgaagcg 653161 ggtaaaggtc ttccggttga ggatgtcatg aaaaatgcgc ctgaccataa agacggctat 653221 attcgtgtgc catcaattct ggactaaagg agggacacaa gaatgtcatt atttgatcat 653281 aaaatcacag aattaaaaca gctcatacat aaaaaagaga ttaagatttc tgatctggtt 653341 gatgaatctt ataaacgcat ccaagcggtt gatgataagg tacaagcctt tttggcatta 653401 gatgaagaaa gagcgcgcgc atacgcgaag gagcttgatg aggcggttga cggccgttct 653461 gagcacggtc ttcttttcgg tatgccgatc ggcgtaaaag ataatatcgt aacaaaaggg 653521 ctgcgcacaa catgctccag caaaattctc gaaaactttg atccgattta cgatgctact 653581 gtcgttcagc gccttcaaga cgctgaagcg gtcacaatcg gaaaactgaa catggacgaa 653641 ttcgccatgg ggtcatctac agaaaactca gcttacaagc tgacgaaaaa cccttggaac 653701 ctggatacag ttcccggcgg ttcaagcggc ggatctgcag ctgcggttgc tgcgggagaa 653761 gttccgtttt ctcttggatc tgacacaggc ggctccatcc gtcagccggc atctttctgc 653821 ggcgttgtcg gattaaaacc tacatacgga cgtgtatctc gttacggcct ggtcgcattt 653881 gcgtcttcat tggaccaaat cggaccgatt acacgtacgg ttgaggataa cgcgttttta 653941 cttcaagcga tttccggcgt agacaaaatg gactctacga gtgcaaatgt ggacgtgcct 654001 gattttcttt cttcattaac tggcgacatc aaaggactga aaatcgccgt tccgaaagaa 654061 taccttggtg aaggtgtcgg caaagaagcg agagaatctg tcttggcagc gctgaaagtc 654121 cttgaaggtc tcggcgctac atgggaagaa gtgtctcttc cgcacagtaa atacgcgctt 654181 gcgacatatt acctgctgtc atcttctgaa gcgtcagcga accttgcacg ctttgacggc 654241 atccgctacg gctaccgcac agacaacgcg gataacctga tcgaccttta caagcaaacg 654301 cgcgctgaag gtttcggaaa tgaagtcaaa cgccgcatca tgctcggaac gtttgcttta 654361 agctcaggct actacgatgc gtactacaaa aaagcgcaaa aagtgcgtac gttgattaag 654421 aaggatttcg aggacgtatt tgaaaaatat gatgttattg ttggaccgac tacaccgaca 654481 cctgcgttta aaatcggtga aaacacgaag gatccgctca caatgtacgc aaacgatatc 654541 ttaacgattc cggtcaacct tgccggcgta ccgggaatca gtgtgccatg cggattagca 654601 gacggacttc cgctcggcct gcaaatcatc ggaaaacact ttgatgaaag cactgtatac 654661 cgcgttgctc atgcatttga acaagcaaca gaccatcata aagcaaaacc tgaactgtaa 654721 ggggtgaaaa gaattgaact ttgaaacggt aatcggactt gaagtccacg ttgagttaaa 654781 aacaaaatca aaaattttct caagctctcc aacgccattc ggcgcggagg cgaatacgca 654841 gacaagcgtt attgacctcg gatatccggg cgtcctgcct gttctgaaca aagaagccgt 654901 tgaattcgca atgaaagccg ctatggcgct caactgtgag atcgcaacgg atacgaagtt 654961 tgaccgcaaa aactatttct atcctgacaa cccgaaagcg tatcagattt ctcaatttga 655021 taagccaatc ggcgaaaacg gctggatcga aattgaagtc ggcggcaaaa caaaacgcat 655081 cggcatcacg cgccttcatc ttgaagagga tgccggaaaa ctgacgcata cgggcgacgg 655141 ctattctctt gttgacttca accgtcaagg aacgccgctt gttgagatcg tatcagagcc 655201 ggacatccgc acgccggaag aagcgtacgc atatcttgaa aagctgaaat ccatcatcca 655261 atatacaggc gtttctgact gtaaaatgga agaaggctca cttcgctgtg acgccaatat 655321 ctctcttcgt ccgatcggcc aagaggaatt cggcacaaaa acagaattga aaaacttgaa 655381 ctcctttgcg tttgttcaaa aaggccttga gcatgaagaa aaacgccagg agcaggttct 655441 tctttccggc ggcgtcatcc agcaagaaac tcgccgttat gatgaagcaa cgaagaaaac 655501 cattcttatg cgtgtcaaag agggatctga cgactaccgt tacttcccag agccagatct 655561 agtcgagctc tacattgatg atgaatggaa ggaacgcgta aaagcaagca ttcctgagct 655621 tccggatgag cgccgcaagc gttatatcga agagcttggc ttgcctgcat atgacgcaat 655681 ggttctgacg ctgacaaaag aaatggctga tttcttcgaa gaaaccgttc aaaaaggcgc 655741 tgaagctaaa caagcgtcta actggctgat gggtgaagtg tcagcttacc taaacgcaga 655801 acaaaaagag cttgccgatg ttgccctgac acctgaaggc cttgccggca tgatcaaatt 655861 gattgaaaaa ggaaccattt cttctaagat cgcgaagaaa gtgtttaaag aattgattga 655921 aaaaggcggc gacgctgaga agattgtgaa agagaaaggc cttgttcaga tttctgacga 655981 aggcgtgctt ctgaagcttg tcactgaggc gcttgacaac aatcctcaat caatcgaaga 656041 ctttaaaaac ggaaaagacc gcgcgatcgg cttcctagtc ggacagatta tgaaagcgtc 656101 caaaggacaa gccaacccgc cgatggtcaa caaaattctg cttgaagaaa ttaaaaaacg 656161 ctaataaaaa agcagccctt agaggctgct ttttttatgg tcaaattgag ataaagacaa 656221 gatgagggcc cgaagccttt caacttcttt gtcgttggtt ccggccaaat tggacagcat 656281 gcctttaata atcggcttgc gcggtttatc ctgagtcaat tcttcctcga taacatcaag 656341 tgacacggtg atatcctcgg gcagcgtgct gttttctttc actttctgaa tgtcctcaag 656401 cagctggtct tttcccgcag gcatcgggtt aaaaatgtct tttgatacaa tcggattgag 656461 tgcagaacgg ctcagcccct gtacaagatc atccagtctc tcaataataa aggctgagat 656521 ttcttctgca tcgatattaa gctcaccgtt aaataccatc acgttcatat aggaatgcac 656581 aatgcctctt gccatgatgg acagatctgc gacataccgc tcgattcctt cgccatagga 656641 taccagcaag gcgttccggt acagcttatc cgtctccatg gttactttgt aaaagtattg 656701 cttgatttct tgattttccg gaatgatatt ttcggtaagc aaaagaacga taaaatcttt 656761 atgatcgcga aaatcctcaa attgagcgcc aatttgcttt tttaacactt ccttaggcgg 656821 ctttccggcg agatcttctt ctatattttt cattttgttc atagacatac cgatataata 656881 ttcacaggca gataacagca gcgcttcttt cgatttgaag tgcaaataaa aagcgccctt 656941 cgaaatgccg cattcactgg cgatttcttg gatcgtcgta gctgcgaatc cttttttcgc 657001 aaataaacga atgctggttt ttatgattct ctcttttttt tcattcatga cgtgcttccc 657061 cttaatcctt gaaaaattta gtaaaatttt ctggtatatg agttgacgtt gttgcgttat 657121 aacgtttagt attatataga atgaccagtc agtcaataaa aaatgtaatg gaggatatga 657181 tgaaccacgt tattaatttc gttctgaaaa acaaattcgc cgtatggctg atgacgatta 657241 ttgtaacggc agccggcttg tatgcgggta tgaatatgaa gcaagagtct attcctgacg 657301 tgaacatgcc ttacttgacg atcagcacga catatccggg tgcaacacca agccaagtgg 657361 ctgatgaagt gaccaaaccg gttgaacaag ccgtacagaa cttggacggt gtcagcgttg 657421 tgacgtcgac gtcctatgaa aacgcatcgt cggtcatgat tgaatatgat tatgagaaag 657481 atatggacaa agcgaaaaca gaagcagctg aagcgttaga aaacgtcaac ctgcctgatg 657541 acgcgaagga tccggagatt tcacgctaca gcttgaactc attcccgatt ctgacgctga 657601 gcgtgtccag tgataaagat aatctgcaag agctgacgaa acaagtggag gacagcctcg 657661 tttctaagct tgaaggcata gaaggcgttg cgtccgtcca agtatcaggc cagcaggtgg 657721 aagaggttga attctctttc aaagaagaca aactgaagga atacggcctt gatgaagata 657781 cagtcaagca agtgattcaa ggttcagatg tgacaactcc gcttggattg tacacattcg 657841 gaaatgaaga aaaatctgtc gtcgtcagcg gcgatattga aacaattaaa gatttgaaga 657901 atatgagaat cccgacggca tctgcttcaa gtgcaggcag cagcgcagca tctcaagcag 657961 gtgcgcagag tgctcaagca gcccaaagcg cgcaagcggc agcacaggtg cagcaaagcg 658021 caagcacagc agtgccgacg gtcaagcttt ctgacattgc tacaattaaa gatgtgaaaa 658081 aagctgaatc cgtttcacgc acaaatggca aagacagcat cggcatcaac atcgtcaaag 658141 caaacgatgc gaatacggta gaggttgccg acgatgtcaa agctgagctg aaaaagttca 658201 aagaagacca taaaggcttc aattacagcg caactctcga catggcggag ccgatcacac 658261 agtcagttga cacgatgtta agcaaagcca tcttcggtgc tatttttgcg attgtgatta 658321 ttctcttatt cttaagagat atcaaatcaa cattaatttc tgttgtttca attccattat 658381 cattgctgat cgcactcctt gtgctgcagc agcttgatat cacattgaat attatgacgc 658441 tcggcgcaat gaccgttgcc atcggacgtg tagtcgatga ctccatcgtt gtgatcgaga 658501 acatttaccg ccgcatgaga ctcaaagatg agccgctccg cggaaaagcc ttggttcgtg 658561 aagcgacgaa ggaaatgttt aaaccgatca tgtcatcaac gattgtgaca atcgcggtat 658621 tcctgccgct cgcacttgta ggcggacaaa tcggtgaatt gtttattcca tttgccttaa 658681 cgattgtttt tgcgcttgcc gcatccctag tgatttcaat cacgcttgtg ccgatgctcg 658741 cacacagcct gttcaaaaaa tcattaaccg gtgcgccgat taaagcgaaa gaacacaaac 658801 ctggcagact tgcaaacatc tataaaaaag tattgaactg ggcgctgagc cacaaatgga 658861 tcacgtctat catcgcggtt ctgatgctcc ttggaagctt gttcctcgta ccgttaatcg 658921 gtgccagcta cctgccgtcc gaggaagaaa aaacgatgca gctcacatac agcccagaac 658981 cgggtgaaac gaaaaaagaa gccgaaaatg aagctgaaaa agcggaaaaa atcctgcttg 659041 accgcaagca tgtcgatacg gttcagtatt cattaggctc tggcagcccg cttgccggag 659101 gagattctaa cggtgcgtta ttctatatca aatatgaaag cgacacacct gactttgata 659161 aagaaaaaga taacgttctg aaggaaatcc aaaagcaatc tgaccgcgga gaatggaagt 659221 cacaggactt cagctcttca ggcaataata acgaattaac atactatgtg tatggcgatt 659281 ctgaaaacga tattaaagac acggtcaaag acattgaaaa aatcatgaaa gatgaaaagg 659341 atctgaaaaa cgtaaattca ggcctttcca gcacatatga tgagtacaca tttgtcgctg 659401 accaagaaaa actaagcaag ctcggtttaa ccgcgtctca aatttctcag gccttaatgt 659461 cacaaacatc gcaagaaccg ctcaccactg tgaaaaaaga cggcaaagag cttgatgtga 659521 acattaagac agaaaaagac gagtataaga gtgtgaaaga tttagagaat aaaaagatca 659581 cttccgcgac tggccaggaa gtcaaaatcg gcgatgtggc aaaagtgaaa gaaggatcaa 659641 catcagatac cgtgtcaaaa cgtgacggaa aagtctatgc agatgtcaca ggtgaggtta 659701 cctctgacaa cgtcacagcc gtatcagctg ctatccagaa gaaaatcgat aagcttgacc 659761 accctgataa cgtatcgatt gacacaggcg gcgtatcagc ggatatcgct gattccttca 659821 cgaagctcgg tttagcgatg ctggcagcaa tagcgatcgt ttaccttgtg ctcgtgatta 659881 ccttcggcgg agcactagcg ccatttgcga ttctgttctc attgccgttc acagtcatcg 659941 gtgccctggt cggactttac gtatcaggtg aaacgatcag tctgaacgcc atgatcggta 660001 tgctcatgct gatcggtatc gttgtcacga atgccattgt cttaattgac cgcgtgattc 660061 ataaggaagc ggaaggcctg tctacgagag aagcgctcct ggaagccggc tctacacgac 660121 tccgtccgat cctgatgaca gccattgcga caatcggcgc cttgattcca ttagccctcg 660181 gcttcgaagg cggaagccag gtcatttcaa aaggactcgg cgtaacggtt atcggcggtt 660241 taatcagttc aacgcttctg acgctcctga tcgtgccaat cgtatatgaa gtattggcga 660301 agttccgcaa gaaaaaaccg ggaacggaag aagagtaaaa aacaaaaagc ctcagctctg 660361 ctgaggcttt cagcttgttg aaaaaccctc gcattcgttg tcaggtctgc gcgtcggtgc 660421 tcacgaattc tacattcgct ccgctccaat gctccccctt cctagactac aagggttttc 660481 aatcaagctg aaagaatgtt aaggatgaca aaagctcaaa acaagaatca gttttgagct 660541 tttgtgcgtt ttcacctgta agattatgta cattttgttg cgattttttt aactcatagt 660601 ataattaaag gttgttagtg taaaaatgga tcggatactc ttaagtagga tgatgagata 660661 atgaaacgtg cacgcataat atacaatccg acttcaggac gggagatctt taaaaagcat 660721 cttgcccagg tcctgcaaaa atttgaacaa gccggctatg aaacctccac ccatgcgacg 660781 acatgcgcag gagacgctac acacgctgcc aaggaagcgg cattgcgtga gtttgacctg 660841 atcattgcgg caggcggaga cggaacgatc aacgaggtcg tcaacgggct tgcgccttta 660901 gacaatcgtc cgacactcgg tgtgattcct gtcggcacaa cgaacgactt cgccagagcg 660961 ctcggaatcc cacgcgagga tattttaaaa gcggcagata cggtcattaa cggcgttgcc 661021 cgcccgattg atatcggaca ggtcaacggc cagtatttta tcaatatcgc cggcggaggc 661081 cgtctgacgg agctgacgta cgacgtgcca agcaaactga aaacaatgct cggccagctt 661141 gcttattatt taaaaggaat ggaaatgctg ccttcacttc gtccgacaga agtcgagatt 661201 gaatatgacg gcaagctgtt tcaaggtgaa atcatgctgt ttttggtcac gctgacaaac 661261 tccgtcggcg ggttcgaaaa gctcgcgccg gattccagcc tgaatgacgg catgtttgat 661321 ttgatgatac taaagaaagc aaaccttgct gaatttatca gggtcgccac gatggcgctt 661381 cgcggagaac acatcaacga ccagcacatt atttatacaa aagcgaaccg cgtgaaagtc 661441 aatgtatcag aaaagatgca gctgaacctg gacggcgagt acggcggcat gctgccgggc 661501 gaattcgtga atctgtaccg gcacattcac gtcgtcatgc cgaaggagaa agcggaacag 661561 ttggatgact aaaacttggc ttggtaagcc aagctcagaa tgttgacaaa atcctaaaac 661621 agttttcgtt ttaggatttt gtcatctttt cagcgtgatt gaaaaccttt gaagtctagg 661681 aagggcgagc atcggagcac agcgaatgtt gaattcgtga gcaccgaagc acaggcctga 661741 caacgaatgc gaaggtttgc ctacacgctg aaacttggct tgaataggcc aagtttttct 661801 ttcgcttaaa actagaggtg attatagatg aaaatgaaac ccccagtaga aaaaaatgaa 661861 tactacgatg tgacatttga ggatttgaca catgaaggag cgggcgtcgc aaaggtccaa 661921 ggcttcccga tctttgtgcc gaatgcccta cccgaggaaa aagcccaaat caaagtgaca 661981 cgcgtcaaaa aagggttcgc cttcggccgc ctgattgagc tgaaggaaga aagcccgcat 662041 agaacggacg ccccatgccc gatttacaaa caatgcggag gctgccagct tcagcacatg 662101 acctacgaag gccagctcct gtttaaacag aaacaagtca aagacgtctt agaacgcatc 662161 ggcaagctgg acctttcaaa agtcaccgtg cacccgacac tcggcatgga agacccgtgg 662221 aactacagaa acaaagcaca ggtgccggta ggagaacggg aaggcggact cgtcgcggga 662281 ttctatcagc aaagaagcca tgacatcatc gacatgagcg cctgcctgat ccagcaatcc 662341 aaaaacgacg aagccgttca agctgtcaaa gacatttgcg caaactacgg tgtcaaagcc 662401 tacaacgaag aacgccacaa aggctggctc cgccacatca tggtcagata cggcgttgtt 662461 acgggcgaaa tgatgatcgt cttcatcaca agaacaagcg acttcccgca caaagcgaag 662521 atcatcgaag acatcacagc gcaattcccg cacgtcaaat ccatcgtgca aaacatcaac 662581 ccaaacaaaa caaacgtcat ttttggcaac gaaacaaacg tcatctgggg cgaagaatac 662641 atctacgacc tcatcggaga cgtcaaattc gccatctccg ccagatcgtt ttatcaggtc 662701 aacccagagc aaacaaaagt gctctacgac aaagcgcttg agtacgctga gcttcaaggg 662761 gaagaaaccg tcatcgacgc ttactgcggc atcggaacga tttctctctt cctggcaaag 662821 caggcgaaaa aagtgtacgg tgtagagatt gtgccggaag caattgagga cgcgaagcga 662881 aacgccgaat taaacggcaa cacaaacgca gagtttgctg ttggagaagc ggaaaccgtg 662941 attccaaagt ggtacgaaga aggcattaca gctgatacgc tggtcgtcga cccgccaaga 663001 aaaggctgcg acgaagccct cctgcggaca attgtggaga tgaagccgaa gcgggtagtg 663061 tatgtgtcct gtaatcctgg cacgcttgcg agagatttgc gggtgcttga ggatggcggg 663121 tacgtgacgc gcgaagtgca gcctgtggat atgtttccgc atacgaatca tgtggagtgc 663181 tgtgtgttga taaaattaaa agaataaata gtcaaaaatc tatgctgatg gaactgttgg 663241 ttctctaaaa cgataattga tttcaatggt tccatttgca tgtacttcta tttcatctac 663301 taacaaatga agcatttcgg gggtaagtgt accttccttc atgaatttat ctaagctctt 663361 tttaaaatca attatttctt tttcaatctt ttgaaattct aggtccttag atagttggtg 663421 aagggtagtt tcaaaatttg aaatatcttc attggtgata tttatggcta attggtaatc 663481 ttctttagat ataacaccat tagcaagaga gataactaaa ttggatttat ctctcttttt 663541 atcgtttaat ttttcattaa tttcgattat cttagattcg attttttctt tgtactttaa 663601 cgctttttca cttaattctt taaaataatt ttccttactg aatttcaaat atatcttatt 663661 taggttggtt attactttat cagttaaatc tatttcactt acgtaatgat cactacatgc 663721 ttttaaacca tgtttattat aacttccaca aacataacct tttcgattct ttttaaaatg 663781 cattgacctc ctgcaatctt tgcaaaccgc agtatttgta aagagatgta cttcagcttg 663841 aggtctcctt ctttttctag ttattaaaat ctcttgtaca ataagaaagt cttctaaagg 663901 tatgattggt tcgtggcttt tttcaataat tatttggttt tctaggttaa ctgaccttct 663961 tcttttactg gtaacactcg gtctatattc tctacattgt tgtagtgtcc cagtatagtg 664021 aggattttcg agaatttttc ttattgaaga tccgtgccat ttgtcagtag cgttcttttt 664081 gcgggcaagc tgcgagggac tagtgacccc ttcgttatac aatccccttg ctattgcatc 664141 aaagcctttt ccagcaatat attctgaaaa gattctaata tttactattt tctctgcgtt 664201 tgctgaattt gagagagata tgattgtaga acgaactcaa gaaggtaaaa tgttggccaa 664261 gcagaatccg gatttccgag aaggaagacc caaaaagttc acaaagcagc aaatcaatca 664321 tgcattaaca ttactagaaa atcattcgta taaacaagtt gaagatatga ctgggatatc 664381 agtttctaca cttgtaagag ctaaaaagaa gaaagctgct gaagctataa atggataaat 664441 attgtgaatt aattattcaa tatcttgaga aatttttata aaagtaatca aaagtttaat 664501 gggggaaacg aaatggcgct cattgattta gaagataaaa ttgctgaaat agtgaatcga 664561 gaagatcatt cagatttctt gtatgaatta ctcggtgtat atgatgttcc acgagctaca 664621 attacgcgct tgaaaaaagg aaatcaaaac cttacaaaac gggttggtga agtacactta 664681 aagaataagg tgtggtttaa ggaggctaag aaaggaaagc tctttgacgc ccttattgat 664741 atagaacaac aagttgaata tctttcagct aagccacgat atttattagt tactgactat 664801 gatggagtat tagcgaaaga tacaaaaaca ttagaggctc ttgatgttaa atttgaagaa 664861 cttcctcagt atttcgattt cttccttgct tggaaaggta ttgagaaagt agagtttgaa 664921 aaggaaaacc ccgctgatat taaagcagcc gaacgttttg cacggatata tgatgtactt 664981 cgtaaagaaa acaatattat tgagactaat agagggttag atttatttct tattcgttta 665041 ctgttttgtt ttttcgcaga agatactgac atcttcaaac gaaatagttt tacgaattta 665101 attaagactt tgactgaaga agatggttca aatctaaata aattatttgc tgatttattt 665161 atcgtgttag ataaaaatga acgagacgat gttccatctt atttaaaaga gtttccgtat 665221 gtaaatggcc agttgtttac tgaaccacat acagagttgg aattttctgc caaatccaga 665281 aagttaatta ttgagtgcgg tgaattatta aactgggcta aaatcaatcc tgatatcttt 665341 ggttcaatga ttcaagctgt tgcttctgaa gaaagccgta gttatttagg tatgcactac 665401 acaagtgtcc ccaatataat gaaggttatt aaaccgcttt tcctagataa acttaatcag 665461 tcttttttag atgcatacga tgattataca aaacttgaaa atcttctaac acgaatcggc 665521 aaaattaaat tctttgatcc tgcatgtggt tcagggaact ttttgattat tacctacaaa 665581 gaattacggc gtatggaaat caatattata aaacgacttc aagaactctt gggagagtat 665641 ctttatgtac cttcagtaac tttatctcaa ttttacggaa tagagattga agattttgca 665701 catgacgttg caaaattatc actttggatt gctgaacatc aaatgaatga agaattaaaa 665761 aatgaagttc ataatgcagt acgcccaacg ttaccacttc atacagcagg ggatattcgt 665821 tgtgcaaatg ctattagggt tgagtggact gaggtttgtc ccgcacaagg atctgaagaa 665881 gtatatgttt ttggtaatcc accgtatctt ggttcaaaaa aacaaaacaa agaacataaa 665941 tctgatatgt tatcaatttt tggaaaagtc aagaatggta aaatgcttga ttatatttct 666001 gcttggtttt actttggtgc taaatacgct tcaactacaa atgcaaaagt tgcctttgta 666061 tcaacaaatt cagttactca aggggaacag gtttctatct tatggaatga gttattcaag 666121 tttggaattc aaatcaattt tgcctataaa tcttttaaat gggcgaataa tgctaaaaat 666181 aatgctgcgg taattgttgt gattgtaggt tttggcccgt tagataccaa agtaaacaag 666241 tatttatttg ttgatgaaac gaaaaagcta gtttctaaca ttagtcccta tttaactgat 666301 ggtgaaaata ttcttgtttc ttctaggacg aagccaattt cagacttacc caaactgcat 666361 tttgggaaca tgcctaatga tggcggagga ttactcttta ccattacgga atatacagac 666421 gcaatcaata agtatcctga attagttccc tattttaaaa agtttatagg ttcagtagag 666481 tttattaatg gtggtttacg gtattgttta tggcttaatg aagcaaaata tgaaaaaata 666541 aagtctaatc ctctaataca agaaagaatc tcaatttcaa aaaatcacag ggaaaaatca 666601 acagataaag gaacgaataa acttgcatta actccgtgga agtttagaga tactcatgaa 666661 acaactaatt attccattgt tgttccatct gtgtcttctg aaaatagatt ttatattcca 666721 atgggattag caggtgcaga tacaattttg tcaaatctaa tttatgtaat ttacgatgca 666781 gaaatttacc ttctaggcat tttgatgtca cggatgcata tgacttgggt aaaagctgta 666841 gccggaagat taaaaactga ctataggtac tctgcaggtt tatgttataa cactttccct 666901 attcctgaat tatcaacaag aaggaagaat gaaattgaag aagcaattct tgaaattctt 666961 gatcttcgtg aagagcaggg tggtacatta gcagagcttt ataacccttc aacaatgcca 667021 attgaattaa aagtagcaca tgaaaagttg gatggaattg tagaaagagc gtatcgtcaa 667081 aaacaatttg aatctgatga agaacgctta gaagtattgc ttaaattgta tcaagaaatg 667141 acagaacggt aggtgtaagg tgtatggaaa atataattga aattaattat aaccaaactg 667201 gtaaaagtaa gaaaacaaat gaatacggta tgcgtgaaat gcaggcaaga gcttttgaaa 667261 aacgtaactc acaatatctc ttagttaaag caccgccagc ttctgggaaa tctagagctt 667321 taatgtttat cggtttggat aagctcataa atcaaggttt gaggaaagtg attgttgctg 667381 tacctgaacg ctctataggt tcttcattta aaaatacgga tttaaaaagt tatggtttct 667441 ttgaaaattg gaaagttgat cctagaaata atttaactgt tggcggagat aactctaagg 667501 ttaaatcttt tgttcgtttt atggaatcgg acgatcaggt gttaatatgt acgcactcta 667561 ctttgcgatt tgcgtttgaa aaaattgatg ataaagcatt tgataattgt ttacttgcaa 667621 tagatgaatt tcaccatgta tcggcagatg tcaattctcg attaggtgaa ttgttaagaa 667681 gtattattca taattcatca gcacatattg tagcgatgac tgggtcgtat ttccgtggag 667741 attctgtacc aattttatta ccagaagatg aggaattatt tgacaaggta acttattcct 667801 attatgaaca acttgatgga tatgaatatc taaagggatt tggtatagga tatcacttct 667861 atcaaggcca gtacacatca gctattaatg aagtattgga tacaaataag aaaacaatcg 667921 ttcatattcc aaatgtaaac tcaggggaat cgacaaagga taagtacgat gaagttggta 667981 agatacttga tatgattggt gaagttgaat atcaagatga tgatactgga attatttatg 668041 ttaagcgaca ttctgacggt aaaacattga aaattgcaga tttagtagat gaccaagttg 668101 gaagagaaaa tgtcgttgcg tatttgcgta atattgaagc cctagacgat ttagatataa 668161 ttattgctct tggtatggcg aaagagggct ttgactggcc gttttgtgaa catactttga 668221 cagttggtta tcgtggctca cttacagaaa tagtacaaat aattgggcgc tgtacacgtg 668281 atagttacaa taaaacctat gctcaattta ccaacctaat cgcaatgcct gatgcaaagg 668341 atgaagtagt gacttataca gtgaatacaa tgcttaaagc tatttctgcc tcacttttga 668401 tggagcaggt ccttacacct gactttaaat ttaaacgtag aagaaatgaa agtgaaaaat 668461 cttctactac aggagaatta ttcgttaagg gattgaaaga accatcaaca gaaaatgtca 668521 aaaagattat tgaaaatgat attaatgatt taaaagcaaa aatcatgcaa gattcacaag 668581 tccaaaaaac atttagtgga gaagtagatc ccaaagtatt gaacaaagtg ttgattccga 668641 aagttattca aaaagtatat ccaaatttat cagatgagga aattgaggaa gttagacagc 668701 acgttgttct agatacagtt atgaaaggtg ctaagtctga agttgtagga agtaaagaat 668761 ttataagaat ggcagataag tttataaaca ttgaggattt agatatcaat ctgattgatt 668821 ccatcaatcc gttccaaaaa gcatttgagg ttctatcgaa agaattgaac tcaccagtgc 668881 taaaactgat tcaggaaact attgatgcaa aacgtattaa ttttgatgaa gatgaactag 668941 tattcatatg gccaaaggtt taggaatttt atcgttcaac tggtagaaga cctgattcaa 669001 aatctgaaga cccacttgaa aggcgtatgg gtgaagctgt attatacatg caagagctta 669061 ggaggaaacg tgaaaatggc aagtaataga taccattcta ttaatgaaat catggaaagt 669121 cagctgtttt accaaatcac aacaccacct aagaaaacac aaaaagccca gtatgatcct 669181 gaagttgaaa agtttttgga gattattgaa ttcgtcaaag aaaatgggcg agaaccccaa 669241 aaagtcccta ctgatttaac tgaaagaagt ttagcaagtc gattaattgg gattcggaaa 669301 gatcctgatc gtatggaata tttgaaagag tatgatgaaa ttggattact tgaagtaaga 669361 tcgaaggaac taacaattcc taaaatttct tcaattgatg atattctaaa aagtggctta 669421 tctgcattat taggtgataa tttaaataat gatataacta ggtcaatttt tgatacaagt 669481 tcacttcaaa aggttacgac aatgcctgaa tacgttgcaa agcgtaaaaa aataaaagat 669541 tttggaaagt ttgaagagct attcaagaag tgccacaagg aaattacaga gggtaaacga 669601 aaaattttaa ctttcaaaaa tgaacaagac atacagtcaa atagttttta tatattaaaa 669661 ggagttcttc tttatgttga agatgtggga gaacgtaaaa aagcaaaggg aaaaaccaat 669721 gctagacttc gatgtatatt tgaaaatgga acggaatcag atatgttact acgttcctta 669781 tcagcggagt tatataaaca tggtagacgt gtgaccgaca atgaagatac attgttggat 669841 aatgttagag aagatgatgt ttcgactggc tttatttacg tactaaaatc tttgagtaca 669901 gatccgcaaa ttagttccat taagaattta tataagatcg gttttacaac tggttcagta 669961 gaaaatagaa tcaggaatgc agaaaatcaa tcaacttatc tttatgctcc agtagaaatt 670021 gtaaccacat atcaagtgtt caatatgaat gctagcaaat ttgagacggc aatccatcat 670081 gcgctagcaa ataataattt ggatgtttct attttggggg caaatggaaa gatgttagtt 670141 cctaaagagt ggttcgttgt cacacttgaa gatttacaag ctgtaataga tgagattgtg 670201 atgatggttc atctttatga ctaaattagt atattaggat tttagtatta ataataattt 670261 tatagtagac tatgaaaaaa tttgatgcca taacaataac ttgttccgct ttggagtttg 670321 tcacaattgt agaattatgt gttgcgagta ttaataggaa ggggttgagc gaccgcaaaa 670381 aaaattttcg gtgctgtccg caaaagggag tttgggtgtt ttgcgttata tttggttgtg 670441 tgaaggttag cggaaactca attcgtgaag ttaggattgc ggttattacg actgagtagt 670501 ttcgtcatac tcttttagca gtttttctgt cttatgcatt tctttgagca tcggattcat 670561 gtagtcgtta gctgattcta gatatgctct cgtcagagtg tctagtttat ttctaacttt 670621 agagaggtct tcttcgaatt ttccatccga tgattgaagg ataaattctt ttgcctcttc 670681 atatcttttt aatatgtttt tcaccattgg agttggattc ttttgattta ttgtttttat 670741 tacagtgatt gttaaattta tttgttttat taattctttt cttactgtca aggtgatgct 670801 ccttttaaat ctctattcta tttgagagtt gctatatctg tttaatggtt tgatagacta 670861 ctcatcttta taatttagag caatttttac aacttgttcc gctgtgtaat cttcattgct 670921 ccagaaaatt aaatcacttg gtgccggata aggaacattt ttctctaata aatcgagata 670981 ttcactgact ttctcatcat ctaatgttgg gttcattaat tcctttacaa gaaagatcaa 671041 ctcttctttt gtcagtttat ccattgtttg ccctccaata gattgtatct ccattgattt 671101 tacaaatgac tttatttctt ctgataatgt tataggttgt ttgcataatg atagataatt 671161 gtcttgagaa aagttagtct cattatagag tttattaatt gtatttataa caatatattc 671221 atatggaaaa cctctaaaat atctttattt tagattggtt tataaaaaat agctcagcag 671281 agtagggctg agccattttt taattataga ccgaggtaac taattacaaa ttctttatca 671341 tcctcatctt caggcaaaat accaaggttt ttatattccc atattgcgat tctttcatat 671401 ccatctaatt ctgaggctaa aatatcatca taattataat ctaattggaa ttctccgcta 671461 cgatccaatg ttagtgtaag gttagtccaa acatcatcgt tattatttct gtgttcagtt 671521 cttaattctt caaaaagttc tcttagttct cttaacaacg tcttgaaaat atccttgctt 671581 acgttgtaat ggctaggtat atcttgtgaa taaataattt gattattttc tggtgttctg 671641 aaatgaaaaa gaaccattgt ggaatcatct aatacttctg cataaagata tatctttgtc 671701 cattcaccag gtatgatgtc attgagtttt tctccaataa gttgatacaa atcttgcatc 671761 ttcctagttt ccattcttct aacccccagg ctgattttta atagagacgc ttatttcttt 671821 tctgctccca attttgtagg ttacatcgaa atatgatggt ctaagtgaat ccccagaata 671881 gactggttct atttgaactg ctactttttt aggtggtttt ttgcttaggg cttttgccca 671941 ctcctgctcc atctcatacc atttcccacc gctcctatta atctgagaat tcatcggcac 672001 gatattgtca aactggcctg agcctttgaa ttgggtggcg attaaatggc cgccgtcatc 672061 gtcaggcttt cggtcctggg gctttccagc attcgtttgt gcatattggt ttcgtttcgc 672121 ttctcccagc tgcaagtctg ctttgacact tgtaattcta ccatagttgt cagtcgtgta 672181 cgtgtagcct tcttttgttt tgtagatgat attaggcttc agcactttct ttctgctcca 672241 tcttgcgaaa tgctcgccgt atttgacggt taccggcggt acatgtggcg ctggagttcg 672301 tcttccgctt gatgacgttc cgtatggttt cggcaggatg accttggcga atttttgcag 672361 tccttcttta agcgtgaccc cgttgactgc gttgtaagga acgcctgccg gcactaaatc 672421 atgacgggga tgatacggga gaatatccgc aagtgtgaga tctccgattt gatttaactt 672481 ggttttgacg tgtttttttg atacttcaat gcctgtgttt actttttgtt tgatgtgatc 672541 aacggtttgt tttgagactg ttatggcttt ttgggctgtt gctgatttgc ttgctgctgt 672601 tttgactttg gtcgtcactt tggcggctgt gccagttttt gagacggctc ctacgccttt 672661 tgtgccgaca attgatgtga caacagtgcc aaccgcatat gacacccatc ttgctcttga 672721 gtaggtgtca ccattcacca tgtctttttg atacgattct tcgattgccg ctgaaatggc 672781 ttcatacgtt ttgatcgggt gagccatcgc tccggtaatc gcttcaacgg ttcctcccgg 672841 atctgtgacc atatcccaca ggcctacgac cgcgtctttc ccggaatcat aaaggccgac 672901 ggcaacccct ttgaagcctg cttcaagctc acgcgtgttt tcaatttggg tgaagtatct 672961 ctgttgttca gctgtcagat tttcatagcc gatcgttttt gccatttcgt agaattcatc 673021 ggcatctgca taatcgtagt ttttcagtct ttctttcagt ttctcaatct cgcgttcctt 673081 cgcttcctct ttcttaatct tcaagtaagc ctcagtccgc ttttcaatgt cgcctttttt 673141 cttatgtatg tcactctcac ggtacgcctt ggcgttgtag tggatgggtg tggcgttttt 673201 gcctttaccc gttgcttctt ggagcttttg gaagtcggat ttgatgaatt gttcgtttgg 673261 ttcagacagg gcgtattctg ttttcaggtc ttcgtccaag gcgtccaatt tttccagtgt 673321 ttttttgcgt ttgtcgttgg catcggccag ctcgtctttg aaggtttctg ttgaaaacag 673381 gtcgagcggg aggatgtcgt cgatatcgtt taggatgtct ttcatcgctt ttttctgttc 673441 ggacatgatg gatttagatt ttttattggc atttgccagt tcgtgctcca ggaaggattc 673501 ttcgatgtat gcgtctgaga ggcctttgtc ttcggcggct ccggcgatgc tgttgaaaaa 673561 tgcgattttc atgtcgatgt agtcgatcca ctggtcggcg acgccgacgt ggtcgtgata 673621 gaatgccttg atgttgctgg cgccttttcc tgagaattca ctgtcactga gatcagcgac 673681 tccttttaac gcttttctca agttgaccat ttgcgttctt agttctttgt actcttttgc 673741 acggtctgtc gcttccgaaa gcagtgtttt cgcttcaaat actttcatga ccatttccct 673801 tcttttgttc gctcaatatc aaaattttac cacgggtcgg gataaggtgg gggtgagaac 673861 gtgttttggt ggaaaaatga gtcatttggc atgtgtcttt attcgtggag ggattggagg 673921 aaacatggtc gaaatgatat tgattgctac acattttttg gaagtttgta ttctatattg 673981 ttttttaagg agcatgttga tgacgaaaaa acggattaca tttggtttat tagttttaat 674041 ggtatgtgtc atcctgtttg ttctgtatgt tcagttacgc aataaagata gtattcctgt 674101 ccaatcttcc gccattcacc ccgaagaaga ccgcatcttt tttatttact ccaatccttt 674161 cataaaagaa agcgtgctgc tttcaacctc tacaggcgaa cggtttaaca ggcgtacgtt 674221 taaggtggcg gatgtgcctt atattcaaac gaaatcttat gcatcaacag accttgtatt 674281 attggcggaa cacgagcctt tttactacac gctggagaag gatgtgatca aagagcatcc 674341 gctgtcagat ccatttgcgt tttggtatga ggggaaggat gtcactattg aggcctataa 674401 tgttgatacg acgggaaatg agatccacat aaacgacaga aaaacgaaaa aggaatatac 674461 ccttaccttg cctccgcttg tcacaatggg ggccagtgat gagaacttta tttatatcat 674521 tcaaagcatg tctatttacg tgattgacag aaaaacagag gaaatgattg agaccctgag 674581 cttagcctca tacgctgatc aattcgcaga ctcggaggaa tttatcgtcg cgagctcgga 674641 tcataaattg actgtgattg aaaaagggac atggaagacg acatatattg cgtatcctga 674701 agatcttgaa tatgcagata ctgtgtacta tgacaaagaa agcggcagtt tttacgtggc 674761 gtacgaggac aaagagggtg gagcgaactt gctggaatat ggggaggatt tttctattca 674821 cacatacagc ttgaaattcc cttatatgga ggcgaagttt aaggggaatc tattgtatat 674881 agttgcccag gaagagcata aaaagggcat cggcggatac gtgggtgtgt ttgatatcca 674941 ttctaaggag atgctttatc agtttgattt gcctgaggaa caggtgaagg ttcaggattt 675001 tgttgtggtt gacaataagt gaatactata tgaaatagaa tgacaaagac ccttgcataa 675061 agggttcttt tttatgaaaa aaacaaattg acaggatgaa aaaacaattt cttccttcta 675121 tattgttttc aaaatttggg attgatagaa tatgacatat ctcatagaga aggagggaag 675181 ccgttgagtc aagccatacc gtcttcgcgt gttggtgtta agattaatga atggtataaa 675241 atgattcgcc agttcagtgt tccggatgct gagattctga aagcggaggt tgagcaggac 675301 attcagcaga tggaagaaga tcaggattta ctgatctatt attctctgat gtgttttcgg 675361 caccagctga tgcttgatta tttggagccg ggaaaaacat acgggaatcg ccctacagtg 675421 acagagcttc ttgaaacgat cgagacccct cagaaaaaac tcacaggtct tttgaaatac 675481 tactctttgt ttttccgcgg catgtatgaa tttgaccaaa aagaatatgt ggaagcgatc 675541 ggatattatc gcgaggcgga gaaagaactg ccgtttgtgt cagatgatat tgagaaagcg 675601 gaattccatt ttaaagtggc agaagcgtat tatcacatga agcaaaccca tgtgtcgatg 675661 tatcatattc ttcaagcctt ggacatttat caaaaccatc ctctatacag cattagaacg 675721 atacaaagct tgtttgtgat cgccggcaac tatgatgatt tcaaacatta tgataaagcg 675781 ctcccgcatt tagaggcggc gctggaattg gcaatggaca ttcaaaatga caggtttatc 675841 gccatttctc tattgaacat tgcaaacagc tatgacagat caggagacga tcagatggct 675901 gtagaacatt tccaaaaagc ggcgaaagta agcagagaga aagtgcctga tctgcttccg 675961 aaagtcttgt ttggattaag ctggacatta tgtaaagcgg gccaaacaca gaaggcgttt 676021 cagttcatag aggaaggatt agaccatatc acagcacgtt ctcacaaatt ttataaagaa 676081 ttgtttctgt tcttgcaggc cgtgtacaag gagactgttg atgaacgaaa aattcatgat 676141 cttttaagct atttcgaaaa aaagaacctg cacgcttaca ttgaagcatg tgcccggagt 676201 gctgccgctg tttttgaaag cagctgtcac tttgaacaag cagctgcgtt ttatcggaaa 676261 gtgctgaaag cccaagaaga tattctaaaa ggagagtgtt tatatgccta ttaagaaaaa 676321 agtgatgatg tgtctggctg ttactctagt tttcggaagc atgtcgtttc caaccctgac 676381 aaactccggt ggatttaagg aatcgacaga tcgaaatacg acgtatatcg atcattcccc 676441 ttacaaactt agtgatcaga agaaagccct tagctagggc tttttcttgc tttacggaag 676501 acgttccatt ttccacatcg cggcattcct tctatttcta acgcaagaca ctcgaaacaa 676561 ccaaaccatt tgaggtataa tggataaagt gaataacagt atttagattg atatatatga 676621 aagagagtgg aacatcatgg gccgtaagtg gaacaatatt aaagagaaga aggcgtctaa 676681 ggacgcaaat acgagtcgga tttatgcgaa gtttggccgt gagatttatg tggcggcgaa 676741 acagggcgag cctgatccgg aatccaacca ggcgctgaag gttgtgcttg aacgtgcgaa 676801 gacttacagc gtgccgaaaa acatcattga acgtgcgatc gagaaggcga agggcggagc 676861 ggaagagaat tacgatgagc ttcgttatga gggcttcggg ccgaacggat caatgattat 676921 cgttgatgcg ctgacgaata atgtaaaccg tacggcgccg gaagtgcgtg cggcgttcgg 676981 gaaaaacggc ggaaacatgg gtgtgagcgg atctgttgct tacatgtttg acgcgacggc 677041 tgtaatcggt gtggaaggca aaacggctga cgaagcgctt gaaatcctga tggaagcgga 677101 tgttgatgta cgtgacattt tagaagagga tgacagcgcg atcgtgtatg ccgagcctga 677161 tcaattccat gcggtgcaag aggcgtttaa aaacgcgggt gtcgaggaat ttacagtagc 677221 ggagctgaca atgcttgcgc aaagtgaagt aacgcttccg gatgatgcaa aggaacagtt 677281 tgaaaaattg attgatgcat tagaagattt ggaagatgtt cagcaggtat atcataacgt 677341 tgatttaggt gagtaaggag tgagcaggct gttatggcct gctttttttg tcccggaaat 677401 tgttttagct gtatgtaggc ggccgcctat acgatctata agatattctc atactctgga 677461 ctgtaaccta tgtgaaggag agagtaaata tgactgatac aagacatatg tatggcggac 677521 ctggttttgg tcattatcag ggctttggta ttggccaccc gggctatggc atgcaaagca 677581 caggctatcc gggctatggc atgtatggag gccacccggg ctatggcatg caaggctacc 677641 cagatcacgg catacatgga ggagtcggcg gctatccggg atatggtggg tacggcggtt 677701 acccaagcgg cggctatgga ggctctccgg gaactggaag ctatccgagc atgcaccatg 677761 aaaatgatgg ccatcaccac tattatcacc atcatcatga tggaaaagat aatcttcatc 677821 accatcatca ccatgttgga aaggataatc atcaccacca tcatgatggt cattatggcc 677881 accatcatca ccatatgggc cactggggaa aagacggtta taaataaaga agatgatgat 677941 aaaaagagga cactcttgca gatcaagagt gtttttttag cttttttctt gactgttcag 678001 tctggaaaat ggtaacattt gtttcaggag gtgatcattt tttggggagg aataaagaat 678061 ttgatacggc gcttgttctt cacagggcga tagaggtttt tggagagtat ggctacgaag 678121 gaacgtctct tcaggatctg ctctctcatt taggcattgc gcgccaaagt ttgtatgata 678181 cgtatggaac gaagcgtgat ttgtttttgt ccgctgtgaa atcgtatctt gaagggaaaa 678241 acgctgccgt tatggaaagg cttgaagcgc caggatctgt aaaggaagcc attcgtgata 678301 tttttcagga gggtgtcaat gccctgaggg atccggaacg ggcgaaggcg tgctacatta 678361 ttaacagcgc gattgaacag atcccgcatg accctgagct tgcccggtat tttgaaagac 678421 aatccaagca gcttgaggac gctttttatc acgggctttt aagagcgaag gatcaaggag 678481 aattgaatgg cgaagatact gatatatctg cgcttgctcg gtacctgaat cagagcaggc 678541 tgtcactgac atttattgca aaagtgacgg cagatatgga tcggcttcag gaccatgttg 678601 acgtgagttt atcagtgctt gattaacatg tggtaaagga ttctttgccc atgtatgtac 678661 tttttggact gaatagtcta gaaataaaaa tgaggtgatg atgaatgttg atgaatgagt 678721 ttgaaaaagc atgtgaaaca ttgagaaagt ttatggctta tatgcttgag aaggacatga 678781 agagctggac ggagctttgg gatgagaatg ctgtatttga gtttccttat gcgccggagg 678841 gatcaccaaa aagaatagaa ggaaaagcgg ccatttacga ttatattaaa gattatccta 678901 agcagattca tctttcttca tttaccgctc cgacagtgta ccgttcagca gactcgaata 678961 cggtgattgc ggagtttcaa tgtgacggcc atgtgattga gactggactg ccttatcgcc 679021 aaagctatat cagtgtcatc gaaacgagag acggccgcat tgtgcgttat agggattatt 679081 ggaatccgct tgttgtaaaa gaggcctttg gaggatcatt tttgcaaaca gaggagagtg 679141 ggaaatgatg aaacagaatc cgattttaat cacgggcggg accggcacag tcggcagccg 679201 aatcgccagc cgtttaataa agctgggata cagagtgcgt attgcaagcc ggaaaaaggg 679261 cgcgcttgct gatgctgagt atgtgtattt taattggaag tacgcctcca gttttacgcc 679321 tgctctggaa caggtaaaac agatctatct tgttgctccg gtcggtgtat ttgatccggc 679381 tccctatgtg cttccctttt taaaggaagc aaagcgtctc ggcgcaaagc gggtagtgat 679441 gcaaagtgcg tctgttgtct ccgagaacgg tcccgtgttt ggcgcgcttc accaggcagt 679501 gcgcgagttt ccagaatgga cggtgctgcg gccctcatac tttatgcaaa atttcatcaa 679561 tgtccagcac cgcatgtcta ttcaaacgga ggggcgcatc acaacggctt cgggtgaagg 679621 aaaacttggg tttattgacg ctgatgacat cgcagaaaca gccgtcaggg ctttgattga 679681 tgatgttcct catcaaacac atcatattct gacaggtccc gaggcgctga gctatgccga 679741 agcggcggag atcattggag ctgcggcggg acgccgggtg gagcatgtca gcatttctcg 679801 ttccgagctg cagcataaaa tggaggcagg aggtttgccc gcggattatg cccattttat 679861 ggcgaagctt gatgaggcaa ttagccatgg tgcggaacat cgggtaacgg atacagtgaa 679921 gcgtgtgacg ggaaaagaac ctcgttcgct gtcagagttt gcggctgctc atgctgcata 679981 ttggacctca ttttggactg aatagtctag aaagaccttc ggcgcttccg aaggtcttct 680041 tattgaaaaa gctaagtcgt gttttagtca taatcatgcc tcctgcctca tacctattaa 680101 ggtcattgtt tttgagaaag gaggagccgg aatgaaggat atgcagccgt ttacgcctgt 680161 caaatcatat acgccctttc acagccgttt tgatccctgt ccgcccatag ggaagaaata 680221 ttacagaacg ccccctaacc tttatatgac ctttcagcct gagcacatgg agcagttttc 680281 gccgatggag gctttgagga aaggcaccct ttggaaggat ctctatgatt tttatgaaaa 680341 cccttatcga gggggagacg cacatggcaa aaaaggttga cgccgaatat tatcgtcagc 680401 tagagcaaat acaggctgct gattttgtgc ttgttgagct gagtctttat ttaaatacac 680461 atcctcatga tgaagatgcg ttgaagcaat tcaatcaata ttccggctat tcaaggcact 680521 taaaaagaca gttcgaatcc tcttacggac cgcttctgca gttcggcaac agccccgcgg 680581 gcaaggattg ggattgggga aaagggccat ggccgtggca agtataagga ggaatgcctg 680641 aatgtgggtg tatgaaaaga agctgcaata ccctgtcaag gtcagtacgt gcaacccgac 680701 gctggcgaag tatttgattg agcagtatgg cggagcggac ggcgagctgg ccgcggctct 680761 ccggtatttg aaccagcgtt atacgattcc tgataaggtc atcggccttt taacagatat 680821 cggcacggag gagtttgccc atttggaaat gattgcgacc atggtctata agttaacgaa 680881 agacgccaca ccggagcagc tgcgtgaagc tgggcttggc gatcattacg tcaatcacga 680941 cagcgcgctt ttttatcata atgcggcggg cgtgccgttt accgcgagct atatccaagc 681001 gaagggcgat ccgattgccg atttatacga agatattgcc gcagaagaaa aggcgcgggc 681061 gacgtatcaa tggctgattg atatttcgga tgatcctgat ttaaacgatt ccctgcgttt 681121 tttgcgtgag cgtgaaatcg tacactctat gcgcttcaga gaagcggttg aaattttaaa 681181 agaagaacgg gataaaaaga agattttcta ataggcagat tggcctctct ttcatacacc 681241 cttttacata cagagaaaat ggtctgtttt tgcagtttgg tctgcattat aatcaaggtg 681301 tgtgtgcaag cttacttttt gattgggagg cctttatgac agcttttaag attgagaacg 681361 aaacgattgc agatggattt tacgcgtgtc cggccgtcta tgaggatgca gaatcgatta 681421 ccgggttgct cgtccgaaca gctgaatggc tccgggatcg gggttctaac caatggagcg 681481 gacttctcaa agggcaagat atacatgata tcacggggtc aattgaaaag ggacatgtgt 681541 ttgtgtttaa aaaagatgaa gagcttgcgg ctgtcgtgat gctgctgcct gcaccgagcg 681601 agtgggaccg gacgctttgg ggagacgatg ggcatgagga gtccatttat ttacaccgcc 681661 tcgcagtaag ccgccggttt gcgggacagg ggcttggagc ccgcgtcctt cagtgggcgg 681721 agacgggcat acactttccg gaaaaaacgc ggatccggct tgactgtgtc gctgatagtg 681781 acgccctgca ttccttttat cggcgtatgg gatatgaatt catgggtgct gatgcgtccg 681841 gatatcattt gtttgagaaa gagattacgg cagaataagc gtcctttgca gggggctttt 681901 ttgtcttttt ctaaaaggga ggcaggcgat gtgtggtcaa tattatttgt gacagggatt 681961 gtgacggctt gtctgtttgc tggcgtatcc gtattgatgc ggatgagatt tcctgacaaa 682021 agtcggccgg aatggatgtt ggccgggctg atcgtccttg gtgtgtttgc gatctggtac 682081 agcctcgtgt atgtacgcgg ctgggaaggg gctgcgctcg gaatgcttgg attcaatgtc 682141 attttcggag ccattgccgg atatttgatc gataaggcca tccggcgtta caggaaaaga 682201 taaggctgct gccgtctctc aacaggtcga aattttcaca gaccggcagg aattttcttt 682261 cgaaaggaga aatacatatt actttaaaat gaaagcgttt tccaaagcag gaaggtgatg 682321 ttgatgatac acagtgtggc aaatgggctg aatcattttt gtacgtgggt gatgagactg 682381 gcctatttga atgtgctttg gattttgttt tctcttgcag gcctggttgt atttgggctg 682441 atgcccgcta ctgccgcgat gtttacagtg gcgagagaat gggcgaaggg gaatacagat 682501 gccccggtgt tttctgtctt ttttcggacg tttaaaaagg aatggcgggc atcacagatc 682561 ctcgggctta tcgttgtgac ggctgccctg tttctgtttg cggatatgcg gatagcggct 682621 cagatggacc agcctgtgct cgtcaatgta ttcgtgagca ttagtttgat tttcgcgttt 682681 gttgtgctgt atgtgttccc ggtattttct cattttgacg taaaaatcag agaggtgctg 682741 agcatcagct ttttcattgc cttcagtcgt ccggcggtga cgcttttgat ggcagcgggc 682801 gctgtcggtg tgctttgtct cgttctgttt catgtcacgt ttctattgtt tttcagcggg 682861 agtttactca gcctgatctt aacgaagctg tcctttaaag cgtttcggtc aatggatcag 682921 cggcaggaga aagaaaaggc ggcatgaaga aaagagttgc tggctggtac aggcggatga 682981 agattaagga taagctgttt gtgtttctat cgttgattat ggccgtatcc tttctgtttg 683041 tatacagcgg ggtccagtat gcctttcatg tgtatgatga gcagatttac cgcaagtcct 683101 cggaggtgct tcggatgtct tctgaaagga tcgaagacga gctgaagaag atagaggatg 683161 tgtcatatga aatcattaca gacgaacaga ttcagcgcat cctgagcatg caaaatcggg 683221 atgatacgta tgatcaatat caaatgaagc aggagctgtg ggatcagctt gcgggatatg 683281 ccagcgatga aaagtacatc gattccattc atgtgattga tgcccgcggc tcagagtatt 683341 cagccggaag cagttcttca gatcttttgc agcaggagca ggaagaggta tttaagcgag 683401 cgaaagcgaa aagtggaaga aatctttgga tgacgctcgg cgggtcagac cccgtcctga 683461 tttcagcacg gcagatcagg tcctatcacc agctgagtct gaacggcttg ggcatggtac 683521 tgatccaggt caatgtaaaa cagatgattc gtgatgtgcc gaaggattgg ggcgattcag 683581 tcggagacat tatgattgct gaccaaggcg gtaatttggt gtatacggca catgcatcag 683641 cgcatgttcc tgaggcagca aaagagacgt tgaagcaccc cggttatgac ttgataaaaa 683701 agaatggcaa acgttacttt atttcttatc ttcaatcatc ctaccaaaat tggagctact 683761 ataacgttat cccctttgat cagatgttcg caaaaatttc ctttatgaaa acagtgatcg 683821 gcacatgctt tcttctcttt ttctgtgtgg ttttgctttt cggaaggaaa atcgccaaca 683881 gcatcacgga gccgattgaa cagcttgtga ccgcgatgaa atcggtacag cacagcggca 683941 ttgaagcagg tgtgtcgctt tctctgccgg aacatacaca ggatgaggcc ggcatgctga 684001 accgccattt tactgtcatg atgaaacgga ttaatgagct gatggaagaa aatgtggaaa 684061 aacagctcat cattaaagaa accgaattga aagcactgca agcccagatc aatccgcatt 684121 ttttatataa cacgctcgag tccatcaatt ggctggccaa ggcgaatcag caaaagcaaa 684181 tctcaaaaat ggtggaatcg ctcggttttc ttctgcgaaa cagcatacat atgaagaagg 684241 atatcgtgac cattcaggag gaggcggaca ttgtacgtca ctatatgacc attcagcgat 684301 ttcgatttga agagcgcctg aaattcacgt tggatattga cgatgaggtg aagcattgcc 684361 tcattccgaa actgacgctc cagccgcttg cggaaaatgc gattcaatac gcgcttgaac 684421 cctttacaag gccatgcgcc atccggattc aggcgaaaaa ggcgaagggc tgtgtctgta 684481 ttacggtcga agataacggc cctggcatgg atggacggat tcttgaatca acgggtggaa 684541 gaggaatcgg actttggaat attcgcgagc gcatcagcct gacattcgga gagccatacg 684601 gattgcggat tcatagtgag catgaaaagg ggacgaggat tgtgatcaca ataccgtgcc 684661 gaaatgaggt ggtgtgatgt ataaaatact gctggctgat gatgagagga ttatccttga 684721 tggaatggcg ggaatcattg agtgggagtc gcttggcgcc tcattgatcg gaaaagcgca 684781 gaacggacat gaagcatatg aaaagattgt acataagcag ccgcatatcg tcatcacaga 684841 cgtcaaaatg cccggcatgg acgggcttga gctgatcaaa aaggtgtcag ccgtcagccc 684901 gtcggtgcaa tttatcgtcc tgtccgggtt tggagagttt gagtacgcaa aggaagccat 684961 gaaatatggg gtgaagcatt atttgctgaa accctgcaat gaacagcaga ttatcagctc 685021 gctggaggaa atcattgctg agctgaagcg gcaagatgtg cacaaaaaga aaacagccca 685081 tctgaaacac gagctggacc atatccgttc ctttgcagcc gatcaatact tggaaggctt 685141 gatcgccggt gtggcccagc tttctccgcc gccttcactt gccggaaaaa agatccgcct 685201 cttgatctta aaaggggaac aatctattga tgctgcagcc agagaggcac tcggatcggc 685261 actgacagcg gtttgcagca gcggtgaatg gaccgtgctc gccgtagagg agaacgccgc 685321 tgaaaaggtg gcggaggttt ttgcggaccg caagatggcc atcagtcagg cgggagaact 685381 ccggcacgcg gggcagctgt ttcgtgacac agctgaagcg tctggtgacc tgcatgggag 685441 cgcagtgatt tcaaaaatga tcaggcttat tgccgacgag ctcggaaatc cgaatctgtc 685501 cttaaaatgg gcggcgaagg atatgctgtt tatgaatcct gattatctcg ggaagttatt 685561 taagcaggaa acaggcgaga aattttccca atatgttaca cgggtgcgtc ttgagcatgc 685621 gatgaagcag atgaaaataa ggagggacgt gagcgtttca gaaattgctg aagaaatcgg 685681 gtttggcgat aatccgaagt atttcagtct tgtttttaaa aaatataccg gtctgacacc 685741 gtcagaattc agaagaaaac agggaggcgc ttccgcagga tagccatctc tgtttttttg 685801 actttcgcca ctgttttttg agtgtttcgc cctatccgaa cgctttaaaa taaaatgtaa 685861 gcacttacat taaagggggg attggtttga agaagatttg ttacgtgctg ttatcccttg 685921 tctgcgtctt tttgttcagc ggatgttcag cgggtgaaga ggcctcggga aaaaaagaag 685981 atgttacact cagaatcgcg tggtggggcg ggcagccaag gcatgattat acaactaagg 686041 taattgaact atacgagaaa aagaatccgc acgtccatat tgaagcggaa tttgcgaact 686101 gggatgacta ctggaaaaag cttgcgccca tgtctgccgc cggccagctt cctgatgtca 686161 ttcaaatgga taccgcttac ttagcccaat acggaaagaa gaaccagctg gaagatttaa 686221 cgccgtatac aaaggatgga acgattgacg tcagttcaat cgacgagaat atgctgtcgg 686281 gcggaaaaat cgacaataag ctttatggat ttacgctagg tgtcaacgtg ctgtctgtga 686341 ttgccaatga agatttgctg aaaaaagccg gtgtgtctat caatcaggaa aactggacgt 686401 gggaggatta cgagaagctg gcgtatgatc ttcaggaaaa agccggtgtc tacggttcca 686461 acggaatgca tccgcctgat attttcttcc cttattattt gcgcacaaag ggtgagcgct 686521 tttataaaga agacggcact ggcctcgcgt atcaagatga tcagctgttt gtcgattact 686581 ttgaacggca gctgaggcta gtgaaagcga aaacgtcccc aacacctgat gaaagcgcac 686641 agattaaagg gatggaagac gattttatcg tcaaaggcaa atcagcgatt acatggaact 686701 actccaatca atatttgggc tttgcccggc tgacagactc gccgctgtct ctctatctgc 686761 cgccggagca aatgcaggaa aaggcgctga cactgaagcc cagtatgctg ttttccattc 686821 cgaaaagctc tgagcataaa aaagaggcag cgaaatttat taatttcttc gtgaataatg 686881 aggaagcgaa ccagctgatt aaaggcgagc gaggcgttcc agtctccgac aaggtggcgg 686941 atgcgattaa accgaagctg aatgaggaag aaaccaacat cgtggagtat gtagaaaccg 687001 cgtcaaaaaa catcagcaaa gccgatccgc cagagcctgt gggaagcgcg gaggtcatca 687061 agctgctgaa agatacgtca gatcagattc tgtatcagaa ggtatcgccg gaaaaagccg 687121 ccaaaacgtt ccggaaaaag gccaatgaga tattagagag gaataattga cgggaaatgg 687181 ggctgacgca atgaaaaaaa gccggagtat aagaaaagac aatctggcgg gatatgcttt 687241 tatttctccg tttatcatcg ggttcctatg ctttacggtg attccgatgg gggcgtccct 687301 gtttctgtcc ttcacgagct atgacttgtt tacggcgccg aaatggatcg ggctcgacaa 687361 ctttaaggaa atgtttacgg gtgacgaaaa gtattggcag tctctgaagg tgacgtttac 687421 gtatgtgctt gccggggttc cgctccgcct cggcttcgcg ctttttatcg ctgtcatttt 687481 aaacaatgca gcaaaaggaa cggccattta cagaacgctc ttttatctgc cttcgatcat 687541 cggcgggagc gtcgccgtgg cgattatgtg gcgcaatatt tttggcaatg acggggtcat 687601 caatgcgctg ctgttttttg tcgggattga tcaaaaaatt ctttggtacc agaatccgac 687661 aagtgcgctg tggacattga ttctgctgtc cgtctggcag ttcgggtcgt caatgctgat 687721 ttttttggcc gggctgaaaa acattccgtc ttcgtatttg gaagcggcaa gtgtggatgg 687781 ggcaaatcgg gtgcagcgtt tcttcaagat cacgcttccg atccttacac cgattatttt 687841 ctttaaccta gtgatgcaga cgatttctgc ttttatgaca tttacacctg cctatatcat 687901 ttcgaagggc gagggcgggc cgcttgacgg gacacttctc tattcgctct atttgttcca 687961 gcgtgcgttt aactattttc aaatgggcta cgcatcggcg atggcgtggg tcatgcttgt 688021 cattgtcggg ctgattacgc tcatattgtt taaaacatcg tcatattggg ttcattacga 688081 gtcaaaggag gaatgacgga tggagccggt caaccagcct gtcagagaag ccccggtttt 688141 tgagagaaaa aaagccgggc gcgtcagtcc caaacgcata ctgttccatg tttttacggc 688201 aacgctggcg gtgttgctgc tgtacccggt tatttggctg tttgtcagct cgtttaaaga 688261 aagcgccagt atttttacaa cctcacattc tctcattcca gaccctttta ttctcagtaa 688321 ctatgctgaa gggtggaagg gcattgcggg acagccgttt ctgacgttta ttaaaaactc 688381 ggcgattatt gtcgggctgt caacaatcgg tgccgtcatg tcatcggctg tcattgcgta 688441 cggatttgcg cgtataccgt ttaagggaaa aaaattttgg tttgcgtgca tgatggggac 688501 gttaatgctg cctcatgaag tgttgatgat tccgcagtat attatgtttg cgaaattaga 688561 ctggctgaat tcctttaaac caattgtcgt tccgcaattt ttcgggcatg cgttttttat 688621 ctttctgatg atccagttta tccggacgat tcccgaggag ctggatgaag ccgcgcgaat 688681 cgacggatgc ggacgctttg cctgcttttg gcggatcatt ctcccgctga ttgcccccgc 688741 gcttgcgacg tctgcgattt tctccttcta ttggaagtgg gaggagctga ttcagccgct 688801 cttgtatttg aataagccgg agctttaccc tgtttcactt gcgctgaagc tttttctcga 688861 tacagagtcg gcttcgaact ggggcgcgat gtttgccatg tcagccgtct cgttattgcc 688921 tgtgattctt gttttctttt tgtttcagaa atatatcgtt cagggcatca gtacgaccgg 688981 attaaaataa aaaggagtgt tgcagatggc acagcttatc tttgatgaag aaaaggtgac 689041 gtcggttatt gaccggatcg tgaaacggac atttcagatg gattttgcgt gggattggcc 689101 gggcggcgtt gcgttttacg gtgtggcgga ggcctatgaa gcgacggaaa acgaggaata 689161 tatcaatctg ttaaaaacgt gggtggatga acagctggag gatgggctgc cgccgctttc 689221 gatcaacgga gtttccattg ggcatacgct tttgttcctc cacaaggtga caggtgatga 689281 cgtgtatttg gaaacagcgg ccgagatggc ggaatatgtg ctgcataagg cgccgcgctt 689341 tggcgagggt atccttcagc atacggtgaa tgcggcagaa tacgtattcc ctgaacaggc 689401 atgggcggat acgctgatga tggctgggct gtttatgctg agaatcgggc gggtcatgga 689461 gcgtgaggat tattttgaag acggcctgcg ccagtttcac ggacatgagg atgtgcttca 689521 ggaccctgtc acgaatttgt actaccacgc ctgggacaac aaagcgcaaa atcatctgtc 689581 ggggatttat tggggcaggg cgaacggctg ggcggcactc acgatggcaa aggcgctccc 689641 gcttattgag gtgacacatc cttcctttat gatcatcgac ggatcgctca gagaccagct 689701 gagcgcgctt gtccggcttc aggatgaatc agggctgtgg catacaattt tggatgatcc 689761 ggattcttat ctggaggttt cggcatcagc gggtattgct tctgctctga tgtcgagcgg 689821 aaagctgtat acaaaatatg tgcagaaatc gcttgccgcc attttggatg cagtggaaga 689881 ggacggacgg gtcagcaggg tatcggccgg gacagccgtc atgaaaaatg ccgaaggata 689941 caaacaggtg ccttacaaac gaatacaagg atgggggcag ggacttgcgc tgacgtttct 690001 tgctgatgtt ttgaaaacga aaaaacgctt gtatcagtaa agatagcggc ggggggagag 690061 ggatgaaaaa acagcctcaa cagaaggaac gggtttctcg ctggaaggga acgtatttca 690121 aaagaaactt tgtcttcatt ttgctgattg cctgtattcc cggattgctg actggcggcg 690181 caatctactt tctttcgatc gacaaggtgg agaaagagct gcagagatcg catgaaacac 690241 aggtggcgcg tgaggtcagc cgaatggatg agaagctggg agtgcttgaa ctggcactca 690301 cccagatggc ctacgattct tcactgatga acggattggc cgagagggat ttggagaaag 690361 actttacgtt ctcctatcaa ttaacgaaaa agctgtttct tttgcgggat cagcagccgc 690421 tgatcgagca ggcttccatc tttctgaaca gcccccggcc acttgtgctg agccctgaat 690481 acagcgcttt gacagaacag gaggcgcttc gcaagtatcg ctcgctgctt gcctcagacc 690541 acagcattta ttggaaacgg tcgggaaacc aagcgatgct gatccagctc attccgggcg 690601 cggcggagaa accgttcggc gcgatcatgc tggcggttga tccgaaagaa atggaatcaa 690661 tcctgcaaag cttgtccccc tatcctgatg gcagtgcgtt gcttttagat caaaatcgag 690721 aggtgctgtt tcatgagggg gaaaaagatt ttgaaaagac tttacttcat gagataaaaa 690781 aacagcctgc tgagaacggc cattttcaga tggaatggaa aggcaaggtg tattctgtct 690841 cctttggaga aatgaaccgg atgcatcagc aatggacctt tgtgtcagcg gcgcctcttt 690901 cagctattac agcgccgatg gtgtttttat caaaagtgat catcgtgatg ctggtcattt 690961 gcatcggttt ggcggtgtgc atgacatggt atgcatcaaa aaaaatctat cgtcccatcc 691021 agcatttgct tggcttgttt accggaggag agaagaaaac atggcaggcg tccgggcagg 691081 atgaattcaa atggattgaa aagagatggc aggatctatc ccttgaaagc cggaagctcc 691141 aacagcagct cctgcggcag acgccccata tgaaaaagag ttttttgcag catctcttac 691201 agagcgattt ttactatgac aacgaggaaa gcctcagatt tcggatggag gaggctggct 691261 ggaacatcgg cggaaacgtg tttcatgtgc ttgatctaca ggtgacaggg ctccgctgtg 691321 aaaaaagcat cttccgtgaa ggtgatgaac agcttgccgt gtttacactg actaatatcg 691381 ctgaggaatt ggcggctaaa cgcgtttttc agctctccat acttgatatc ggccggcttt 691441 ctgtcaccgt tcttgtgatg aaaacaaaca gctctgatct gaaggcgtat ataacggagc 691501 tggcacgcca atttggagat gtaaccggac tatgcctgac ctcgacattg agcagcaaga 691561 cggagcgtgt cacggaaatt ccttctttat ttcaggatgt gaaatgcggc aaatcccgca 691621 ggaagtttgc taaccgggat caggtcattg atttgcaggc cgacttccct cgggatgagc 691681 agttcgctcc ttattaccct tttgagctgg aaaaacaaat tgttcagacc atccggctgg 691741 aaagaaaaca ggaagccaag gaactgatag atggatgtat gaaggaactg tcggaaaaag 691801 cggccataga caggcatgtg cattccgccc tgattcagct gttttcccgc attcaggagg 691861 atattttgca ttccgggctc aatcccagcg aactgtttca gcaccggaat ccgtttcttg 691921 atatttcaga attgcgcgaa cctaacgaag cggcggcctg gctgatggat gtagtggtga 691981 cgccttacct ttccaagctt gagggcagaa aaaacagaca gcaaaagcag ctggcagaac 692041 gtgtgattgc gatgattcac gaacagtata tggcggacat ttcattggaa agctgtgccg 692101 atgcgcttgg catgaattcc tatacgttaa gcaaggcatt taagcaagtg accggcatta 692161 attttatcga ttatgtgacc cagatcagaa tcgaaaaggc gaaagaactg ctggtcaata 692221 cgaataaaaa aattcatgat gtgtctgaag aagtcggcta tcgccacaat tatttcaatc 692281 ggatttttaa aaaacaggtc ggcatgccgc cgggtgtctt caggcaaatg tatcaggaaa 692341 cgccgtgaaa ggagagaaca tgtgatgaag aaaccgattc aagtattttt agcgggggat 692401 tccactgtga gtgactgccc gcctcatgaa gcgccgatgg cggggtgggg gcaggtattc 692461 gggcaattgt tttctgaagg tgtgctggtc cgcaatcatg ccaaaggagg agcgagcacc 692521 aattcttttg tggaggaagg aaggcttcaa gcaattgccg agcacatcac acaaggcgat 692581 tatttgttga ttcaattcgg ccacaatgac caaaaaccgc gggggacgaa gccgtactcc 692641 acatttcagc agtttcttac cttgtttgca gatacggcac gcgaaaaggg cgcgcatcct 692701 gtgttcgtca catcggtgca gcgccgccgc tttgatgaaa acggacggat cgagcatacg 692761 ctcggtgagt atcccgatgc gatgaaagca ctggcgaagg agctcgatgt acctgtgatt 692821 gatctgcttg cgaaaacaaa ggtgctgtat gaagcatacg ggccggagga gtcgaagcga 692881 ttgttcgttt ggtttcagcc gaatgaacat ccgaattacc cggacggcat tgaggacaat 692941 acgcattttt cggaaaaagg tgcaatggag gttgcgaagc ttgtggcaga aggcattgaa 693001 gagctcggac ttccgcttaa ggaccacctt gtgagccggg agggaaaaga acatgtataa 693061 ggaaggcgct tgcttgtacc gcaatccgct ccggtctaaa agcgatgtga aggattggcg 693121 gatggaggga ggcggacaga tctcatttga cgatcacagc ttgcacctgt cacatgtcca 693181 ggatgaagcg cactttgtct tttggtgtcc ggaaaccttt ccagacggca tcattgtgac 693241 atgggacttc tctccgatcg agcagcctgg actgtgtatg ctgttttttg ccgctgcggg 693301 tattcgcggc gaggatttgt ttgacccaag tctcaggaaa agaacaggaa cataccctga 693361 gtatcattca ggagatatca atgccctcca cctgtcgtat ttccgcagaa aatacgcgga 693421 ggaaagagcg ttccgcacct gcaatttaag aaaaagccgc ggtttccatc tcgccgcaat 693481 gggggccgat ccgctgcctt ctccagacga cgctgattct ccgtatcgta tgaagctgat 693541 caaagacaaa ggctatgtgc acttttcaat caatggtctg cccattcttg agtggatgga 693601 cgacggcagc acatatgggc ctgtgttaac aaaaggaaaa atcgggttcc ggcagatggc 693661 ccccatgaaa gccgtttaca gggattttgc cgtgcatcaa gcggtgagaa gatgaagacg 693721 actgtaacgg atgcgcttta tgcaggctgc gaagcggtgg tgaaaatagc atggctcaac 693781 gggctgtggc tgttgtttac acttttgggc ggcgttcttt tcggatgggc gccgagcaca 693841 gctgcgatgt gtgccgttat aaggaaatgg ctgatggggc aaaaggatgt cccgatattt 693901 tcgttatttc tcgataccta taaaaaagag tttctcaagg ttaatgcgat cggattggcg 693961 ttttcggctc ttttgctcat attgtctgcc aactatcatt atttttctgc cagtacgaat 694021 tggctgtcct ttgccgtaac aagctgcacg ctgcttgcag ggcttttgta tatcatcgcg 694081 ctgatgtatg tgtttcccct ttatgtgcat taccagctcc cgcttcgcaa atatattccg 694141 caggcactgc tgtttggcgc catgagaccg ctgacaactg gctgtatgct gatcgggtgc 694201 ggatttgtcc tttatttgct gtatacgctt cctggcctga tcccatttta cggcccgtgt 694261 ttatttgggc ttgtgttgat gttttttgct cttaggggat ttcaaaagac ggaggcccag 694321 caccatcaag ccgggtaaca aaaaaatgac aaataagcaa aaaagtgcag tgtccgaaat 694381 aggcagatgc aaaaaagtga aattgaagac agctcacaaa gcgcataaaa tccaatttaa 694441 gtaagcgctt acagataaat gagaaggagc tgtctgatga ttagacgaag gaaacgcatg 694501 tttaccgctg ttacgttgct ggtcttgttg gtgatgggaa cctctgtatg tcctgtgaaa 694561 gctgaagggg cagcgcggca gatggaagcg ctgaaccggg ggcttgtagc ggtcaagacg 694621 gacgggggca tttttgtcag ctggcggttt cttggaaccg aaaacgcatc tgttttgttc 694681 aatgtgtaca gagacgggca aaaactgaat gctgcgcctg tcaaaacaac gaactatgtg 694741 gataaaaacg gttcggcggg ctcaacgtat acggttcggg ctgttgtaaa cggtaccgaa 694801 cagccggctt ctgaaaaagc ctccgtatgg gcgcagccgt atcattccgt cccgctggat 694861 aaaccggctg gcggcacgac gccaaagggt gaatcttaca cgtacagcgc taatgacgca 694921 agtgttggcg atgtggatgg tgacgggcaa tacgagctga tcctgaaatg ggacccgtcc 694981 aactcaaaag acaattcaca ggatggctat acgggtgacg tgctgattga cgcgtataaa 695041 ctggacggca caaagttatg gcggatcaat ctcggcaaaa acatcagagc gggcgcgcac 695101 tacacccagt ttatggtgta tgaccttgat ggtgacggaa aagcagaagt ggcaatgaaa 695161 acggcagacg ggacaaaaga cggcacgggc aaagtaattg gaaatgccaa tgcagattac 695221 agaaatgaac aggggcgtgt gctttcaggc cctgaatatc tcactgtgtt tcaaggttca 695281 accgggaaag agcttgtcac cgcaaatttt gaaccggcgc gcggcaatgt gtcggattgg 695341 ggagacagct acggcaaccg tgttgaccgt tttctcgccg gcattgccta ccttgatgga 695401 cagcggccga gcctgatcat gaccagaggg tattacgcta aaaccatgct agttgcctat 695461 aacttcaggg acggaaagct gtcaaagctt tggacgctgg actcctcaaa gtcaggaaat 695521 gaagcgtttg ccggacaggg gaatcacaac ctgagcatcg cggacgttga cggggatgga 695581 aaagatgaga ttattttcgg ctcaatggct gttgatcatg acgggaaagg catgtactcg 695641 accggcttag gccatgggga tgccctccat acaggagatc ttgatccggg ccggccgggg 695701 cttgaggtgt ttcaagttca tgaggacaaa aatgcaaaat acggcttatc tttccgggat 695761 gctgcaactg gaaaaatcct ttggggcgtt tatgccggca aggatgtagg ccggggaatg 695821 gctgctgata ttgacccgcg ttatccggga caggaggtgt gggcaaacgg ttctctctac 695881 tcagcgaaag gggtcaaaat cggaagcggg gttccgtcct cgaccaactt cggcatctgg 695941 tgggacggcg atctgctccg ggaacagctg gacagcaacc gaattgataa gtgggattat 696001 caaaacggcg tatcgaaaaa tatgctgact gcatcaggcg cagcggctaa caacggcaca 696061 aaagcaacac caacgcttca ggctgatctg ctcggtgact ggcgcgagga agtggtgtgg 696121 agaacggagg acagcagtgc tctgcgcatt tacacgacga ccattccgac tgagcacagg 696181 ctgtatacgc tgatgcacga tccggtgtac cggcttggca tcgcctggca aaatatcgcc 696241 tataaccagc cgccgcacac aagcttcttt ttaggagacg gcatggcgga acagccaaaa 696301 ccaaatatgt atacgcctta actgaaaggg ggaaggaacg ggctgcgcgc agcccgttcc 696361 catcaaatga aaccaaaaaa gaggcaaatg gaatacctga ccagaggttt gattgcggta 696421 cagacagaac agggcgtgtt tgtcagctgg cgttttctcg gcacggatca tgagacgacg 696481 gcttttcacc tttatcggga tggaaagcgg atcacccgcg atccaatcgc tgaaagcact 696541 aattttctcg atcaaaacgg aacggctgac tctgtttatc aagtggcggc tgtcaataaa 696601 ggacgggaag aaaagctttc caagaaagct cgtgtttggc aggaaaatgt cctggaggtt 696661 cctcttgcca aaccggaagg cggtgtgacg ccggacggaa agccgtacac ttacagcgcc 696721 aatgatgcca gtgtcgggga tatagacggg gatggagaat atgaaatgat cctgaagtgg 696781 gacccgtcca attcaaaaga caacgctcat gacggttata ccggggaggt gctcatagat 696841 gcctataaac tggacggcac ctttttgtgg cgcatcaacc tcggcagaaa catcagagcg 696901 ggtgctcatt acacgcaatt tatggtgtat gaccttgacg gtgacggaaa agcagaaatc 696961 gccatgaaaa cagctgacgg cacaacagac gggaaaggac atatcatcgg tgatgagcag 697021 gccgatttta gaaacgaaca gggcagaatt ttgtccggtc cggaatattt gaccgtgttt 697081 aaaggagaaa ccggtgaggc gctcacgacc gtggaatatg aaccgccccg cggcaagctg 697141 gaggattggg gagacggcta tggaaaccgg atggaccgtt ttctcgccgg gaccgcttat 697201 ttggatgggg agcggccgag ccttgttatg gcgcgcggct actatacgag aaccgtgctc 697261 gtggcatacg atttcagaaa cggaaggctc aaaaaacgat gggtatttga ctccaaccag 697321 ccgggacatg aagcatacgc aggacagggg aaccacagct tgagcgtggc ggacgtcgac 697381 ggagacggaa aggatgaaat catatacggc gcaatggctg tcgatcatga cggaaccggc 697441 ctgtactcaa cgggcctcgg gcacggagac gcgatgcatg taggggatct ggacccgtca 697501 cgaaaagggc ttgaagtgtt ccaggtgcat gaggacgcca cgaagccgta cggactgtcg 697561 ctgcgagatg ccggaaccgg tgagatatta tggggcgtcc atgctggaac tgacgttggc 697621 cggggcatgg cggctcatat tgatccaagc tacaaaggat cgctcgtctg gggaattgat 697681 ccgccgggca atgatggcat gtcgtacggg cttttcacga gcaaaggcga aaaaatcagc 697741 gacaaagcgc cctcttcagc caatttcgcc atctggtggg acggtgattt ggtcagagaa 697801 ctgcttgatc atgactggga cggaacgatc ggcaggccaa agattgaaaa atgggatgct 697861 gaaaacggct gtctgaagac gatatttcag ccggccggcg tgttgtccaa caacggcacg 697921 aaaggaaacc cggttcttca ggccaacctg ttcggagact ggcgggaaga agtgatatgg 697981 agaacggaag acagcagcgc gctccgtatc tatacaacaa cacatctcac ccgccactgc 698041 ttttacacgc tgatgcatga tccggtttac aggctcggca tcgcctggca gaataccgcc 698101 tacaaccagc cgccgcacac gagcttttac ctcggaacgg gaatgaaaaa accgccgaag 698161 cccgccctgt acatagcggg aagcaaagcg gaggcgccgc tgtaggagga ctaagggata 698221 agacgcaaag gctgaacgct acgccaagat gattagagaa ctggcaggac gaaccaatgc 698281 tcaagcgctg tacgcaccgg ttttttcaag ggaagagcta tccgtgatgg aagctgtata 698341 aaaaacgagg aggaatgaaa aaatggcaaa tcatatttat cttgccggcg attcgactgt 698401 tcaaacgtat ggagacagca caaatcaagg gggctggggg cagtttctcg gctcgcatct 698461 gccggagcat attcaagtga tcaacagagc gatcggggga agaagctcga aaacatttgt 698521 ggaagagggc aggcttcagg caatcctcga tgtgattgag ccggatgatt ggctgttcgt 698581 gcagatgggc cataatgacg cgtcaaaaaa taagccggag cgctacaccg agccctatac 698641 tacttataaa caatatttaa agcagtatat cgcaggcgcg cgggaaaaag gcgcccatcc 698701 gcttctcatt acccccgtag cccgctttca ttacgaaaac ggcgtgtttt tgaacgattt 698761 tcctgattac tgcattgcca tgaagcagac ggccgctgag gagaatgtcc agctcattga 698821 tctgatggag aaaagtctcg ctttctttac tgagaagggc gaggaaaaag tgtacaccta 698881 ttttatgatt tcagaaggga ttaacgatta cacgcatttt acaaaaaaag gcgcaaatga 698941 aatggcgaaa cttgtggcaa aaggcataaa ggagctcggc ctgccattga cagaatcgat 699001 catcaaagaa aggtgaaaat gtgatgagaa aactgtatca tggcgcttgc tattatccgg 699061 aattatggga tgaagagacg attcagcagg acattgacat catgcgtgaa gttggcgtaa 699121 atgttgtgcg gatcggcgaa tttgcctggt cagtcatgga acctgaagaa ggaaaaattg 699181 acgtcggttt tttcaaagaa atcatcgccc ggctgtatga tagcgggatc gaaacgatta 699241 tgtgcacgcc gacgcctacc ccgccgattt ggttctcaca tggccggccc gaacgcatgc 699301 atgccaatga aaaaagagag atcatggggc atggctcccg tcagcatgcc tgtacgaaca 699361 acccgtattt ccgaaaaaaa gccgccatca tcaccacagc catcgccaag gagcttggcc 699421 ggctcccggg gctgatcgga tggcagctag acaatgagtt taaatgccat gttgcagaat 699481 gcatgtgtga gacatgcttg cgcctatggc atgactggct caaaaatcgc tacggggtaa 699541 ttgagcgctt gaatgaagct tggggaaccg atgtgtggag cgagacctat cagacgtttg 699601 agcaagtccc gcagccggga ccggccccgt ttctgcatca tgcctctcta cgcactatgt 699661 atcagctgtt ttcgatggag atgatcgctt cgtttgcgga tgaacaggcc aaaatcatcc 699721 gctgctattc agatgcgccg atcacgcata acggatcagt catgttcagc gtggacaatg 699781 agcgaatgtt tcagaatctc gattttgcct cctatgacac gtacgcttcg caggaaaacg 699841 cctctgcctt tttattgaac tgtgatttat ggagaaatct gaaacaaggg cgcccgtttt 699901 ggattttgga aacgagtccg tcgtatgccg cctcgcttga aagctccgct tacccgcacg 699961 cagacgggta tttgcaggcc gaagccgtat cgtcctacgc cttagggagc caggggtttt 700021 gctactggct atggcgacag cagcgttcag gcagcgagat ttcccacggt tcggttctca 700081 gtgcctgggg cgaacccacc atcggctatc aaaatgtgct ggcggttgag cgggcaagaa 700141 aggaaatcga gcctattatt ctatcgactg aacccgttca agccgaggcg gcgatgactt 700201 actctgacag agcaaaagca tttattaaaa ctgagcctca ccggggactc cggcatcgtt 700261 cgcttgtgac gcatttttat gaacgtattc tcaacacggg gattcaccgt gaccttattc 700321 cggaaggcgc tccactggac ggctatcgct tgctgtttac gccatttgtg ccgtatttgt 700381 cttctgaatt tatcaaaaaa gcttcggcat tcgctgaagc gggcggcatc tggatcaccg 700441 ggccgctgac aggaggacgc acatgcgagc ataccattca taccgattgc ggacttggcg 700501 aacttgagaa aacgtcaggg atcaaaacac tttttacctt tccgatgaat gagaacgtga 700561 atacaggaaa agcgtttggc atcacggcgc cgctcggact gtggagcgcg gtgtttgaca 700621 cagagagcgg aaacaccctt ggcacggttg aagcaggacc gggggcgggc catgcttttc 700681 tgacggaacg gaattacggc gaggggaaaa ttgtcatgct gggctcgctt ccatccggga 700741 aagaagggga tgcgatgctg gaagcgctcg tcaggcatta tgcggaggaa gctgttattt 700801 ccagccggtc ggatgtgaca cccggcacga tcgttgcccc gcgtataggc gaaaacggcc 700861 ttgtgtggat cgttgtgaat atggatggaa aaggcgggag cgtgacattg ccggaatcgg 700921 gaacggattt gttgacgcac cgcttggaaa aggcggggag actggcggtc ggaccgcatg 700981 aataccgtgt gattcaattt gacaatcaca gctgattctt tgtatcgaat cagctttttt 701041 ctatggaggg agagacagat gaaaaagatc aaatggttat caggacagcc aaaggtgaca 701101 agcggcgtga cgtggggcat gccatggaaa aaaggagaat taaaaaaagg agaccgtctg 701161 gcgcttatga atgaaaacgc ggaaacgcga tatgtgcaaa gcgaaccgtc ggcctattgg 701221 ccggacggga gcatcaagtg gacgaagcac gcggcggtgt ttggcggtca ggaaaaccaa 701281 agctttacag tgcacaaaag agaagtgccg cagccaactg aatcgctcag cattcttgag 701341 acagagcatg atatccaagt ggatacagga gcactcgttt gtaccattca taaaacagga 701401 tctgatttca ttcaatcatt gcagatcaat ggaaagccga tcgccgcagg cgggaggctc 701461 gttgcgataa gagaaacgag aaaagagtca gcggcgaaaa tggttctttt gcatgaaagg 701521 tctgtcagct ttatcaaacg ggcggcgatt gagcagagtg gtcctgtcaa agcagtagtc 701581 aaaatcgagg gagtgcatgt gcttcataaa acgtatgagg aatggctgcc gtttgtcatc 701641 cgattaacgt tttatgccgg gctgtctgag atcggccttg tgcacacgca gctgattgac 701701 aggagcggta aactagaatt cgttaagggg ctcggcatcg aattcgacct ttttttggag 701761 ggagagccgt acaaccgcca tttccgcttt gcgggagaga aagggatgta taaagaaccc 701821 gcccagctgt ttggcacacg taaattcaat gaacgatatc cgctttatga aaaacaaatc 701881 aatggcgaaa tgctgtctcc agatgaagag cataaggaat ggtttgcaca tggcacacag 701941 aatgcggttt gggacgatgt caagatcgtg caagattcca gcgatcatta cagcctgtca 702001 aaacggaccg gaaaagatta tgcgtgggtt ggaatgctgc atggcagccg ggcgaagggg 702061 ctctgctatg cgggcggaaa aaatggcggt gtggctctcg gcctgcggta tttctttgag 702121 aaatatcctt cagcactgga aatcacaggt cttgccggca gccgccccaa aatgactatc 702181 tggctttggc ctccggacgg cgaagcgatg gatttgcggc attatacagg aaacactcac 702241 gtggccagcg cgtatgaagg ctttgatgaa atgcgctctg atccgacagg cattgcgaac 702301 acaaatgaaa taagcctggc gtgcttttcg cacatgccgt ctgacgaagt cctcaatgcg 702361 ctggctgaca aatggcaggc gcccccgctc attgtatgcg agccggacgt ctattacgaa 702421 tcaaaagcac tcggggtatg gagcatcatt gacacatccc atccgctcaa aaaagagctg 702481 gaagaacagc ttgatgcggc ctttctgttt tataaaaagg aagtagagca acgcagatgg 702541 tacggttttt ggcattatgg cgatgtcatg catacgtatg acccgatccg gcatatgtgg 702601 cggtacgatc tcggcggata cgcatggcaa aacaatgagc tcgttccgac cctatggctg 702661 tggcaggcgt ttttccgctc aggcagagag gatatcttcc gaatggcaga agccatgacc 702721 cgccatacga gtgaaacgga cagctttcac ctcggtgaat atgccgggct tggctcacgg 702781 cataatgttg tgcactgggg atgcggctgc aaggaagcga gaatcagcat ggccgggctt 702841 cataaattct attattatct gacgggtgat gaccggacgg gagatctttt gacagaagtg 702901 aaggatgccg attatgccct tgtcaaaacc gatccgatgc gcgcttttta cgagaaaggc 702961 aagcacccga ctcacgccag aacgggaccg gactgggcgg cgttttgctc gaactggctg 703021 gcggaatggg agcggaccga aaattcggaa tatctcaaaa aaatcgaaac gggaatcaac 703081 tgtctgaagc ggctgccgct ccgcttatta tctggcccga catttgaata tgatccggcg 703141 acctcgatgc ttcatcatat gggagacggc attgcgggcg gatatcatat gatcattgcc 703201 ttcggcgcgc cgcaagtgtg gatggagctg gctgagcttc ttgatgactg ggaatgggag 703261 gatatgctga gtgaattcgg cgaattttac acactcagtg atgaggaaaa acgaaaaaaa 703321 agcggaggcg ctcttcatga cgggcatttt cactggccga tgttcgccgc cggtatgaca 703381 gcctacgccg caagaaaaaa gcaagatcct catctcgccg ccaaagcgtg gaatcttttg 703441 ctagaagata agctcagcca tacgccgctt ccgatcaaac cggagcgcat cgagacatgg 703501 acgcagctag aggagcttcc atgggtgaca acgaacactg tctctcaatg gtgtttaaat 703561 gtcatagcgg cgctggaact gatcggagat tcccttccgg caaaaaaaga aacatcgggc 703621 aaaaaaggat aacagccgga atttcatagg agaaatggtg caaaaaatga agattgcaag 703681 aatttatgta agcgctttat attgagaggg gcaaagggga aatgcaaatt gaaaaaaggg 703741 ggacttacgc aacatgaaaa taagaatgcg aaaaaaatgg atggccttgc cgcttgctgc 703801 catgatgatc gccggatgca gccattcgga aacatccaat tcagcaagcg gttcgaaaga 703861 tacgatcaaa attatggcgc cgctcttatc gccggaaagc ccaagtgata agagcccttc 703921 attaaaagcg ctcgaaaaat acacaggcaa agagattaag gtcacatggg tgcctgattc 703981 atcctacaac gacaaattca acatcgtcat ggcttcagga gagatgcctc acgcgattgt 704041 cattaaagat aagtcagccg gctttatcaa atctgtcaaa gcaggggcgt tttgggagct 704101 gtctccttat ttaaaagact acaagaattt aagccaggca gatgaaaaga ttttgaagaa 704161 cagctcggtg aacggcgagg tgtacggaat ctacagaacg agggatctga tcagggcgtg 704221 tatgatcatc agaaccgact ggctgaaaaa tgtcggtctg gatatgccgg aaacgcttga 704281 tgatttctat gaagtgctga aagcctttaa ggaaaaagat cctgacggaa acggcaagga 704341 tgatacgtac ggcatggtcg tgccgaaatg gatgggactc ggcaacggaa gcccatggga 704401 tgttctgcaa atctggttcg gcgctccgaa ccgctacggt gttgaaaacg gaaagctgat 704461 tccagatttt acaacgaagg aatacatgga tgcgctcacg ttttttaaaa agctctatga 704521 tgagggcttg atcaataagg actttgctgt catggattct gcgaagtgga atgatccggt 704581 tgtaaaagga aaagcgggtg tcatcgttga tacaggctca agagcgtctc aaatccaaag 704641 cgcgatggag gaggcggatg agtcgaacaa ggatatcatt gatatcgtcg gctcgcttga 704701 gggaccgaat ggcaagcgca ccttcccgac atctggttat tcaggcatga tcacgatacc 704761 aaaatcaagc gtcaaaaccg aaaaagagct gaaagaggtg ctgtccttcc tcgataagat 704821 gaatgataag gaagcgcaga ttctcacgaa caacggagtg aagggccgca attacgagct 704881 caaggacggc gtattcacct cacttgaaaa aaacaataaa tctctcctgt atgagcatga 704941 aggcttggca cagttcagca tgtcgattcc gaaaagcgag tattacatcg aagaccagaa 705001 aaccaagctc ttccagcatc gcaaggacat cataaccgaa ggagaaaaaa tagccgtctt 705061 taaccctgct gagtcgcttg tatctgatgt ctatacccaa aaaggagccc agcttgacaa 705121 catcatcctc gacgcgagaa cacaatttat cattggagaa attgatgaaa aagggttcga 705181 tgatgcggtg gagctttgga aaaaaagcgg cggcaatgaa ctgatgaagg acttgaacaa 705241 attgtaccaa tcgtcaaaat aaaccgatgc gcctgccttt cggcgggcgc cccggtatca 705301 cgaaaggaga acagatatgg aaacagtgcc gaagaagaga gatgcacctg ttctcaccgc 705361 tggaaaaggc atcagctgga tggctgcgct caaacgggac aaatggcttt atcttcttct 705421 tattcccggt ctgctttatt tcttgatttt caaatacttg ccgatgtggg gtgtgctgat 705481 cgcttttaaa gactattcgc catatctcgg cttctggaaa agcgaatggg tcggctttga 705541 ttatttcaaa gactttttta tgaatccgga ttttttccgg ctgctgcgca acaccctcat 705601 gctggcgagt ctggatcttt tgtttgcctt tcccgcgcct ctcattttgg ctctgctttt 705661 gaatgaggta agaaaggccg tgtataaaag atgtatccaa acctttattt acgtacccca 705721 ttttgtatca tggacaattg tggtcagcat caccttcgtt ttctttactg tcgatacagg 705781 tgtgatcaac aaattgatta tgagcctgac aggtgagcag atttctttct tgtcggatgc 705841 agactggttc cggccaatga ttgtgatgca aagcatttgg aaggagacag gctggggaac 705901 gattctattt ttggcagcgc ttgctacggt tgatcaagag cagtatgaag cggccatcat 705961 ggacggagcg gggcggttca ggagaatgtg gcatattacg ctgccggcga ttagaagcac 706021 cattatcgtt ttgttgattt taagaatcgg cagctttttg aatcttggct ttgaacaggt 706081 gtatttgatg acgaactcac tcaaccgcag tgtggctgac atcttcgaca cgtatgtgta 706141 catgatgggg attacccaag gggcgtatag ctacagcacg gcggtcggtt tgtttaaatc 706201 agttgtcggg attatcttga tttttggcgc caattacatt gcgaaaaagt ttgatcagga 706261 aggattgttt tagaggaggg agaggtatgg ctgaaattca cacgatgcac aacaccaaag 706321 ccggacgggt gtttgacgtc tgcaacattc tgtttctcgg cggtgtcggc gcgattacca 706381 ttttgccgtt tttatatatt atcgccggtt cctttgcgac agaagcggaa ctcgcccagc 706441 ggagcttctt tattttcccg aaaaccttta cacttgatgc ttacaagtat gtgttttcga 706501 caccgacgtt ccttcgaagc atgggcgtgt ccatcttcat cacggtggtt gggacggctg 706561 tacagctgtt ttttaccttc acgatggcgt atccgctggc gaaacggcat gtgaagggac 706621 ggaatctgct gttgaatctg gtgattttct ccatgctgtt ttcaggcggc atgattccga 706681 cgtaccttgt cgtaaaatca cttggccttt tggatacgta ttgggcattg attctgccga 706741 tggcgattaa tccgttcaac cttattatta tcaaaaactt ctttcagcag ctgccgcgcg 706801 agctggagga atcagcaaaa attgacggct gttccgaaat cggcgtcttc tggcggatcg 706861 ccctgcctct gtcaaagcca gttattgcga cctttgcgct gttttatgcg gtcgggattt 706921 ggaatgattt cttccacgct ctcttatata tcaatgacag tgcaaaatgg ccgctgcaaa 706981 tggtgcttcg ccaagtcaca attttatcgg atttaacggc gaccaatggt gatacgatgc 707041 aaaatgcagt tccgccggag cagggaatta aactcgctgt cattgtcatt gcgacgctgc 707101 cgattttggc ggtctatcca tttttacaaa aacactttgc aaaaggaatg ctgatcggtt 707161 cggtgaaagg ctgagaaagg gagtgtttca tatcagtaca ttagatcaga ttaagattgc 707221 ctatatcggc ggggggtccc aaggctgggc cagaagcctg atgagtgatt tgtcgattga 707281 tgaacggatg tcaggcacgg tggcgctcta tgatcttgat tttgaagccg ctcagaaaaa 707341 tgaagtgatc ggcaatcaca gcgggaacgg cagatggaga tatgaggctg tttctacttt 707401 gaaaaaggcg ttatcagccg cggatatcgt cattatttcc attttgccgg gatcactgga 707461 tgatatggaa gtcgatgtgc acttgcctga gcgctgcggt atttatcagt ctgtaggtga 707521 tactgtcggg cctggaggga tcatcagggg cttgcgtgct gtgccgatat ttgcggaaat 707581 tgcccgggca ataagagact acgcacctga atcatgggtc attaattata caaacccgat 707641 gtctgtctgt acaagagtgc tgtataaagt gtttcccggc atcaaagcga ttggctgctg 707701 ccacgaggta ttcgggacgc aaaagctatt ggcggaaatg gtcacggaaa ggctggggat 707761 tgaggtgccg cggcgtgagg atatccgcgt taatgtgctc ggcattaacc attttacatg 707821 gatcacaaaa gcctcttacc gccatattga cctgttgcct atattccgtg aattcagcgc 707881 gcactatggg gaatcaggat atgagctgga gggggaatgc tggagggaca gcgtcttttg 707941 ttcggcacac cgtgttgcgt ttgatttatt tgaaacgtat ggcgccatcc ctgctgcggg 708001 tgacaggcat ctggcagagt ttcttcccgg cccatacctc aaacagcctg aagtatggaa 708061 atttcatctc acacctatat cattcagaaa acaagacaga gctgagaaac gacaagaaac 708121 agaacggttg atcgtgcaac aacggggcgt tgctgagaaa gcttcgggag aagaaggcgt 708181 gaacatcata gcggctcttc tcggattggg tgaactcgtc acaaatgtaa atatgccgaa 708241 tcaaggccag gtcttaaacc ttcctataca agccattgtc gaaacaaacg cattcatcac 708301 aaggaaccgt gtccagccga ttttgtccgg agcgcttccg aaaggtgtgg aaatgctggc 708361 ggctaggcat atatccaatc aggaggcagt ggcggacgca ggtttaacaa aggatactgg 708421 cctcgcgttt caagccttcc tcaatgaccc gcttgtccag attgaccgca gtgatgcaga 708481 gcagcttttc aatgacatgc tccaatgcat catgcaaagc tgagcttgcc gattagctct 708541 ttccggttta gaaaggaaag cattgaccat actgatagta taatcaagaa gtaggtgcta 708601 tcaatatggg aaattattta agtgttgcgg tagaactggt ctgcggttta ggcattttat 708661 ttatcatctt aaagcttctc gggaaaaccc aattttctca aattacgccg tttgacttta 708721 tttctgcttt aattttaggt gaattggtcg gaaatgccgt ctacgatcat gaaatcaaaa 708781 tcaaagaaat tatttttgct tcgctattgt ggggcgtgct gatttatatt attgaattta 708841 tcacgcaaaa aatgaaatca tcgcgaaagt tcttggaggg cgagccgaat atcgtcatcc 708901 gcaaagggga gcttcaatat aaagtaatga agaaaaataa gatagacatt aaccagctgc 708961 aaagcctatt gaggcaagct gggagctttt cgatccaaga agtagaatat gcgattcttg 709021 aaacaaacgg gatggtcagc gtgcttccaa aatcagactt tgacaaaccg acaaataagg 709081 atttgcagat tccttcgaag tccgtttctc tgccgatcac gttaatcata gatggagaga 709141 ttgtgcggga taatttgaag gaagcaggtg tggatgaaca gtggctgaaa caagaattga 709201 aaaagaagaa cattgataag acagaggacg tgttatttgc agaatggcat aaaaataagc 709261 cgctgtatac tgtaacgtac gaacaaagca gatcaacatg actcttagaa aaaagcttgc 709321 agcaaggcgc aagcttttta ttgattgtat gtcccttgtt tgacagcacg tacatggtac 709381 atgctcactt cagtgctgat cagatagtca ggctttggtt tgcctttgtt tgctttatgg 709441 ccggcgatat gcgcatcgct tttttcccat tgcttccagt gatcctctga ttcccagcga 709501 atcatgacaa caacttcttc atcaccgcgg cgcacatttt tctcaagcac tgtcacatca 709561 attaaacctt cttgtttttc aatgattcct tcagcgctga aacgttctat gactttatct 709621 gcaaagcctt ctttaaccgt catttttctc aactgtacaa acatttgtct cactccaatc 709681 attctcacat atgaataatt gtaaatgaaa ttcattctca atgtcaaaga aagcgcaggg 709741 cggaatcgaa ccgccgtgcg caacagttta ttcttttaat aaaaacacat ttccgtcttc 709801 gtccttaaat tgaacgaagg tgccccactc catttgattg ggctcaccga gaaattctac 709861 accgtttgtc ttcattttct cgtatgtacc aaagatgtct tcgcattcaa acacaataga 709921 agccttcatt tgctctgagc ctttcatcat ggctttcggg taaatgacta aacgagtctc 709981 ggctcctttt ggcgcaacct ccagccagct tgcttcaggt cccattgggt gatccgctgc 710041 aatatcaaag cctaccttct ctgtccaaaa ttgcttcgct ttctgctggt cctcgacata 710101 tacagcaaca gtgccaattt gtttgatcat agggaaacct ccaagttgaa aagataataa 710161 tactataacc tgtttacggc cgaagtaaca taaaaaaatc agccgggaaa ccggctgatt 710221 attaaaatga gcagcttaca acatcgatgt gatttgtgtc taaggcgaaa taaacccagc 710281 ggcgccgtga ggaatcccaa taaaagccgc cgacggatct tctgccaagg atgatcgggt 710341 aaaaccaaaa tgagcggcca ttggttaacc agacataggt aaatcggaaa aggcaaggac 710401 gaatggtgat tggttcaact aacaaaacgg ctccttgaga accctgcggt tttgggggtt 710461 tcgctggtat ttgggaagga ggaggtccct gcggcgcacc gccgaagcct gggctggcac 710521 cgctgccaat accagggccg gagccgccgc caaagcctgg aacagcacca ccgccaatgc 710581 caggaccgga gccgccgcca gagcccggaa cagcgccgct gccaatgcca ggccatggat 710641 atcggtattc atattcaaaa gcaggccaag gctcataaaa atgccccgca aacatataag 710701 gatcaacata atacatgtga taacgtcctt tctcattgta aactgtacat tgcagtttat 710761 gcgggcggac tcttattggt gcattcgcct aaggatatga agctggaatg ctctcagaga 710821 gcagaatcat ttgatttttc tctagtctta ttcacaattc cgatttatca ttttataatg 710881 aaagtgcttc tattacgaaa aaggagacag accgtgaata tcgatcaatt attatatcaa 710941 tatatcatag acaacactgc ggatattact gagaaatggt tcagtttgcg ttgccagcta 711001 aaaggcgagc tatattccgc cagccattta agtgaagaaa cgaaaacact tttaaccgag 711061 cagcatacat ttaccaatat aacaatcgca agcgcatttc tggaggatca aaccgatttt 711121 caagaaaaca tgacaaaatg ggcgcaaaac gttgcgaaaa acagggtaga gcaggatgtt 711181 caagtgcatg aggtcgtaga agccatatcc aattcaagaa tctcattctg ggacgcagtc 711241 gccacattta taaaagagaa tcaggagatt gtgacaaatg aggatgcaga ccgatggaac 711301 cgcattgtga atcagtcgtt cgataagctg attattgaat tctccgagca gtaccaaaaa 711361 ttcatgctga tgaggcttac atctcagcag gaactgatct cagagcttgg ctgcccggtc 711421 atttccattg ccgatggaat cgggatattg ccgcttatcg gctccattga tacaaaacgg 711481 cacaggtcat tttagaaaca gtgccggtcc gctgtgtcga gagaaaaatc acaagcctcg 711541 tcgttgatct ttcgggtgtt ccgattgtgg ataccatggt ggctcagcaa ttgtacaacc 711601 tgtctaaaac acttttctta ttaggcgtca aagccgtatt ttcaggaatt cgcccggatg 711661 tggcccaaac atcgattcaa ttggggcttg attttagtga atatgaaacg tacggcacgc 711721 tgaagcaggc attagaaaac atgggtgtcc gctgtattgt tgaggaattg gaagaaaaca 711781 aataggaagt ttccaggcat atgattgtcc gtcaccgggt gatcatatgc ctttttgatt 711841 tgaacagaaa tcaccattga tttatcgaaa aaaacataat attataattc ttataagaat 711901 actgtgaatt aaaacctatt caacaggggg gaaggtcttt tggtttctaa atcaacgatt 711961 gatccggaag tgattgaaaa aatcatcagc tcgctggaaa cactcgattt cggcacggtt 712021 cagattacgg ttcatgattc tcagattacc caaattgaga aaatagaaaa gcaccgtttt 712081 tcgctgaaaa ggaaagaatc aaaatgataa tgtaaagggc gtttgttttc attaaattct 712141 ccttaaaaca tatacatatt tcatccaatt tttatataat agacctttaa gatcattttt 712201 taggaggatt tttgacatgc aagctacggt tcacgagagt aagcaatcga tcatgcaacg 712261 cattttgaca gtctttgtct tcacattgct gatcgcgact gtcggccttt ttatcggcca 712321 atttgttcct gtcgctttga tgctgccgct ttctattctt gaagtggcga tgattattct 712381 ggccttctgg atgcgcagaa gaaaagcggt cgggtatgcg tttgtatata cattcgcgtt 712441 cgtttccggc attaccttat ttccgatcgt cagccattac gcttccatcg ccggcgccta 712501 tgtcgtgctc gaagcctttg gctctacatt tgtcattttt gccgtcttgg gcacaatcgg 712561 cgcaaaaatg aagaaggatt tatccttcct gtggtcgttt ctgctggttg cggtgctcgc 712621 actcgcagtg gtagggattt tcaacatttt cagcccgtta aactcagcgg cgatgatggc 712681 gtattccgtg atcggaacca tcgtcttttc cctttacatt ttgtatgatt tgaaccaaat 712741 caagcaccgc cacattacgg aagacttgat tccggttatg gcgttatcgc tgtacctaga 712801 ctttatcaac ttgttcatca acctgctccg cttcttcggc attttgagca gtgatgatta 712861 atgaaaaagc gtctgtcatt ggataggcgc tttttgccat acatcaaaaa ggcaggtgga 712921 gtattggtga aaaaacaaat gggcgcatat gtatctctgg cagcagctat ggcgatcgtc 712981 ggcagttctg tcgttgtcgg caagctgatg gtcgaacgga ttccggtctt tctttcctca 713041 ggattgcgtt ttttgatcgc ttctgtcgta ttgctcatgc tgctgttttg cattgaaaaa 713101 gggtttccgg ctttgacgaa aaaagatgtg ttcgtattac tggtgcaatc attcacaggc 713161 gtgtttttgt tcagtatttg cctgctgtat ggggttcaat atacgacggg aacggaaagc 713221 ggcattttga caagcacaac ccccatgttg atcggtattt tatccttttt cctgctgaga 713281 gaaaaaattg agaaaaagac gctgatcggc attttgctgg cggtttgcgg cgtaatggcg 713341 attaatttgt ttggagccgg gagccaagac gggacgccgc acgccttatt cgggaacatg 713401 ctgatcattg ctgcagtcat tggcgaagcg ttgtttacat tgatggccaa gctgctatcc 713461 ccgcatattt cggcactggc gatttcgacc ttcgtatcgc tcttcggctt cctgtttttt 713521 ctcccgtttg ctttgtttga ggcctcttca tttgattaca gcgtgccgac tgttttggat 713581 tggtcgtatg tgctgtatta cgcgcttttt gtcactgttt tggcgtttta cttatggtat 713641 agcggggtga cgaaggtgcc ggcgggtgta tcgggcattt tcacatccgt tcttccggtc 713701 tcagctgtca ttttgtcagg cgtgatattg aaggagccat ttgagtttgt gcatttcatc 713761 ggcattgcat gtgtcatcgg cggcatattt gttacggtca taaagaaaaa acagccggat 713821 gcgtatccgg ctgcagaaga aaagacgcta tagcctgtcc ggatcggacg ggttttttag 713881 tctttaaaca cgctcagcct ttcaaaaaga tcaccaagca tcttcacgaa catgtctttt 713941 tcctcgtcgc tgtagttttc catgacagcg gatattttgc tgaaatggcc gggcagaaat 714001 tgctccaggc gtgctttgcc ttctgttgtc agttcaatgc tgatttttcg tttatcctct 714061 gtgtgatgcc tgcggctgac aaaaccgtct ctcgccagcc cgtctagcag gcctgtaatt 714121 gttgctttcg tgacatttga ccgcttggca agctctgtcg gacttaacct atgatccttg 714181 gcatcaaaga gcagcatcag gattttgaat tttccttctg aaagccctcg gccagcaaag 714241 taatgctcca tcacatgatt catttttttt gaaatatcaa aaagagataa aaacaattca 714301 agagagccgg cgtcaatatt ggcatacgtt tcggcgtgct ctgttatatg cttatatttc 714361 ggtaaatgtt ttaattccat cgcaattagc tcccgtacat tcgttgtgac acgattataa 714421 aggagggaaa accataacgc aacttggctt ggagatgatt gacagctttt cttgggacat 714481 agtaaggtaa tatagttagg cgcctaacta atacatatag agctgaaaag gtggttattg 714541 atatgaaaca tatgttaata gcaggaggcg gaatcggcgg cttgtcagcg gccatttctc 714601 tccgtaaggc agggttttcc gtcaccttat gtgaagcggc ttcagaaaat cgaaaaacag 714661 gtgcggggat tcttcagccg caaaacgcac tggcggtgtt gaaagaactg ggcgtattcg 714721 aagattgctg taagcacggc tttcaaacag aatggtttaa aacgtttgat gaacagggga 714781 atttgctgtt tcaagtcagt gaatcctttt tagacgattc acttccggga cgcaataata 714841 tcctgcgcaa aacgttaaat gacattctca tgaagcatgc cgaggcagtg ggtgtagaca 714901 tcaagtgggg gaaaaaggtt gtcgcctatg aagaaactgc tgaatcggtc actgccttat 714961 gtgaagatgg agaaaagatg caggctgaca ttctggcggg ctttgacggc attcactccg 715021 ttgttcgtga taagatgctg caaaaggaaa cggaaaaaga gcatctcggc atgggagcgt 715081 ggcgctttta tatcgaactt cctgattaca cattcgagga cgcaacattc atgtatagaa 715141 gcggagacac acaaatcggg gtggtgccat tggcacaaca cgctggctat gtcttcgtcc 715201 tccagccttg cacgagcgat tactgggatg aggaagatac ccggtttgat agagtaaaag 715261 agattctttc tggttttcgg gggctggatt ttgtcacaaa gcacatgtca aaacagcatc 715321 ctgtcatctt taacaaactg gagcaggtcg ccgtgcagga gccatggcat aaaggccgcg 715381 tcatcatcgg aggagacgcc gcccacgccg gtgcgccaac cctggcacaa ggagcggcaa 715441 tggcgatcga ggatgccatc gtcctcgccg aagaactcca aaaccacgcc gaccacgaaa 715501 cagcattaca ggcgtactat aaaagaagag ccccacgagc gctcaaagtc cagaacctat 715561 catctgaaat cgtccgccgc aggctgaaag gagagccggg agcggaagaa ctgattgggg 715621 agtgctatgc ggtgttgagg gaagggtatt aaataggaaa agtccagaaa gtgatttctg 715681 gactttttag tcttgctctg ttttattcct tatccgctca atcacctcat gcagcccctc 715741 aggcttataa aactccaccg gtgaactgcc tttctcaaac gaaatcgtct cggcttcaat 715801 cagcgcgaca tagcgcccgt ttacttttgc gagatgaata gaatcgccaa aatccgctag 715861 caatccctta atctctgttt ctccgacttt cattttcagc tgggcctctg gcgtgtgctc 715921 gatgatttgg gcggaggctt cgatgacttg atgggtgtcg aggcgctctt ggatttcccg 715981 tttttcgctt gcttcccaaa tctcaatgtc gtgctcgaac tgcttgagtt cttcgctgtt 716041 gtcttcaaat gtctcgtaga cgtgctcttg taccatgttc atgacctgat ttttcatgat 716101 ttctggcatc gattctccgt actcgacgaa tttcagaaag tcctcaaaat agcgggcgtg 716161 cgaggcctgg tggattttca gttcaccttc ctcgaccatt ccttcctctg gcatgtacgg 716221 gtattggatg cttttcatgt tttttgtcgt gatcgccatt tcgacttttt taatgagaga 716281 agacgcgtca gagatgcggg cgaccttcgg ctcaaaatca catttcataa tgaagacaaa 716341 tgactcatca aagtattttc tcggcacggc cgaagcgacg agaaacacgc cgccgcgaac 716401 cgcgcttgtg tcaaggtacg tgcggacgaa ctgctcgctc agctcattga agtcttcttt 716461 tgtttccgcc agacgcgcgc ggttgaacat gttgtagttt gggttggaat cgagctcgtg 716521 gccgggctcg acgataaaat ggccgatttt cgtcggcacc tgctcggact gcggatggcg 716581 gtcggctttc cgtttaacga tttttttcag ttccccgtcg agaaagtcct tcagctcgct 716641 ttcttcaaat tctcccgtat caagggtctg gaagtgcttg aactgcttgt tcgcctgctc 716701 atctttgcct tccacctgta tgacataaaa ggataaaaac cgaatttcaa aatccatata 716761 taaactcacc ttattcgcgt attgtacagc ttctcaagta tagaaaaaac agcgatcatg 716821 cgtcaattgg gagaacggaa taatcatgac catgaaaggg aaatgtagtc aaatagaagg 716881 catttcatac ggaaaggaat ggttcgatga aggaaacaag cccgattcct cagccgaaga 716941 cgtttgggcc gctcggcaat ttgcctttaa ttgataaaga caaaccgacg ctttcgctga 717001 tcaaactggc ggaagaacag ggcccgattt ttcaaatcca tacacccgcg ggcacgacca 717061 ttgtagtgtc cggccatgaa ttggtgaaag aggtttgtga tgaagaacgg tttgataaaa 717121 gcattgaagg cgccttggaa aaggttcgcg cattttccgg tgacggattg tttacgagct 717181 ggacgcatga gcctaactgg agaaaagcgc acaacattct gatgccgacg ttcagccagc 717241 gggccatgaa ggactatcat gagaaaatgg tcgatatcgc tgttcagctc attcaaaaat 717301 gggcaaggct caacccgaat gaagcagtcg atgtcccggg agatatgacc cggctgacgc 717361 tcgacaccat tgggctatgc gggtttaact accgctttaa cagttactac agagaaacgc 717421 cccacccgtt tatcaacagc atggtgcggg cgcttgatga agcgatgcat caaatgcagc 717481 ggcttgatgt tcaagataag cttatggtca gaacaaagcg gcaattccgc tatgatattc 717541 aaacgatgtt ttcgttagtc gacagcatta ttgcagagcg cagggcgaat ggagaccagg 717601 atgaaaaaga tttgctcgcc cgcatgctga atgtggaaga tccggaaact ggtgaaaagc 717661 tcgacgacga aaatatccgc tttcagatca tcacgttttt gattgccggc catgaaacaa 717721 cgagcggcct gctttccttt gcgacttact ttttattgaa gcatcctgac aaactgaaaa 717781 aggcgtatga agaggtcgat cgggtgctga cggatgcagc gccgacctat aaacaagtgc 717841 tggagcttac atacatacgg atgattttaa atgaatcact gcgcttatgg ccgacagctc 717901 cggctttcag cctttatcca aaagaagaca cagtcattgg cggaaaattt ccgatcacga 717961 cgaatgacag aatttctgtg ctgattccgc agcttcatcg tgatcgagac gcttggggaa 718021 aggacgcaga agaattccgg ccggaacggt ttgagcatca ggaccaagtg cctcatcatg 718081 cgtacaaacc attcggaaat ggacaacggg cctgtatcgg catgcagttt gcccttcatg 718141 aagccacact tgtgttaggc atgattctaa aatatttcac attgattgat catgagaatt 718201 atgagcttga tatcaaacaa accttaacac ttaagccggg cgattttcac atcagtgttc 718261 aaagccgtca tcaggaagcc attcatgcag acgtccaggc agctgaaaaa gccgcgcctg 718321 atgagcaaaa ggagaaaacg gaagcaaagg gtgcatcggt catcggtctt aacaaccgcc 718381 cgcttctcgt gctgtacggc tcagataccg gcaccgcaga aggcgtcgcc cgggagcttg 718441 ctgatactgc cagtcttcac ggcgtaagga caaagacagc acctctgaac gaccggattg 718501 gaaagctgcc gaaagaggga gcggttgtca ttgtgacctc gtcttataat ggaaagccgc 718561 caagcaatgc cggacaattc gtgcagtggc ttcaagaaat caaaccgggt gagcttgagg 718621 gcgtccatta cgcggtattt ggctgcggcg accacaactg ggcgagcacg tatcaatacg 718681 tgccgagatt cattgatgag cagcttgcgg agaaaggcgc gactcggttt tctgcgcgcg 718741 gggaagggga tgtgagcggt gattttgaag ggcagcttga cgagtggaaa aaaagcatgt 718801 gggcggatgc catcaaagca ttcggacttg agcttaatga aaacgctgat aaggaacgaa 718861 gcacgctgag ccttcagttt gtcagagggc tgggcgagtc tccgctcgct agatcgtacg 718921 aagcctctca cgcatccatt gccgaaaatc gtgaactcca gtccgcagac agcgatcgaa 718981 gcactcgcca tatcgaaatt gcattgccgc cggatgttga atatcaagag ggcgaccatc 719041 ttggcgtatt gccaaaaaac agccaaacca atgtcagccg gattcttcac agattcggtc 719101 tgaagggaac cgaccaagtg acattgtcgg caagcggccg cagtgcgggg catctgccat 719161 tgggccgtcc tgtcagcctg catgatcttc tcagctacag cgtcgaggtg caggaagcag 719221 ccacaagagc gcaaatacgt gaactggcgt catttacagt gtgtccgccg cataggcgcg 719281 aattagaaga actgtcagca gagggtgttt atcaggagca aatattgaaa aaacgaattt 719341 ccatgctgga tctgcttgaa aagtatgaag cgtgtgacat gccgtttgaa cgatttttag 719401 agcttttacg gccgttaaaa ccgagatact attcgatttc aagctctcca agagtgaatc 719461 cgcggcaagc atcgatcaca gtcggtgtcg tgcgcggccc ggcgtggagc ggccgtggcg 719521 aatacagggg tgtggcatca aatgatttag ctgagcgtca agccggtgat gatgtcgtga 719581 tgtttatccg cacaccggaa tcccggtttc agcttccgaa agaccctgaa acgccaatta 719641 ttatggtcgg gccaggcacg ggagtcgcgc catttcgcgg tttccttcaa gcccgcgatg 719701 ttttaaagcg ggagggcaaa acgctcggtg aggctcatct ctattttgga tgcaggaacg 719761 atcgggattt tatttaccga gatgagcttg agcggtttga aaaagacgga atcgtcactg 719821 tccacacagc cttttcccga aaagagggca tgccgaaaac atatgtccag catctcatgg 719881 ctgaccaagc agatacatta atatcaatcc ttgaccgcgg tggcaggctt tatgtatgcg 719941 gtgatggcag caaaatggcc ccggatgtgg aggcggcact tcaaaaagcg tatcaggctg 720001 tccatggaac cggggaacaa gaagcgcaaa actggctgag acatctgcag gataccggta 720061 tgtacgctaa ggatgtctgg gcagggatat agataaagaa gactggagac atccagtctt 720121 tttagtcctt tcgaaaaaat ggtgatcgcg ctaaacattg atgcatacaa taacttcagt 720181 ccgccggaag ggcgggctgt ctgcaaaacc tatttttcgt ttttgctagt ttatgttatt 720241 cttatactcg gtatctattt cttttttcaa aggcacacat gacaaaagaa atcctttttt 720301 tatttccgag aaaaaaatgt gaaacgaaat gaaggtttct ttcgtccagt gattggtttc 720361 caaatggttg taataaaaat gatatggtgc gaaacataaa tattccggct tgccgcggtg 720421 tatttattgt tgtgtgatgc cttgattttg tttggaaaga aggaattgga aggcaggata 720481 taaagagcag gtaaatatga atgaagaact taaagtgttt aagaaagtag aggttgccat 720541 gaagaaactt ttttcttaca aacttagctt ttttgtgctg gctgttatac tgttttgggc 720601 aaaaacgtat ttatcctaca agactgagtt taatcttggg gtaaaaggca caactcagga 720661 gatcctcctg atatttaacc cattctcaag cgccgtcttc tttttaggac tggctttgct 720721 ggcgaaaggg cgtaaatcag ccattattat gctgattatc gatttcttga tgacatttgt 720781 gttatatgca aatattttat tctatcgttt ctttgacgat ttcttgacgt tcccgaacat 720841 taaacagtcc ggaaacgttg gaaacatggg agacgggatt ttcagtatca tggccggtca 720901 tgatattttc tatttcttag atattatcat tttgattgcg gtattgatct ggagacctga 720961 attaaaagaa tacaaaatga aaaaacgctt tgcatcttta gtgatccttt ctgggatcgc 721021 actgtttttc atcaacctgc actatgcgga aaaagaccgt ccgcaactgc tgacaagaac 721081 gtttgaccgc aattatattg tgaaatattt aggtttatac aactacacca tttatgacgg 721141 tgtacagacg gctcaaacag agacgcaaag agcctatgca agcagcgatg atttaacaag 721201 tgtcgagaat tacacgacgt ctcattatgc gaaaccaaac gccgagtact tcggctctgc 721261 caaaggcaaa aatatcatta aaattcacct cgaaagcttc cagtcattcc tgattgacta 721321 caagctaaac ggtgaagagg tgacgccttt cttaaataaa cttgcgcacg gcggggaaga 721381 tgtgacgtat tttgataact tcttccatca gacaggccag ggaaaaacat ctgatgccga 721441 gctgacaatg gataactcga tcttcggtct tcctgaaggc tccgcgtttg tgacgaaagg 721501 cgaaaacacc taccagtcgc ttcctgcgat tttagaccag aaggaaggct atacaagcgc 721561 cgtcctgcat ggtgattaca aatcgttctg gaaccgtgac cagatttaca aacatatcgg 721621 atatgacaag ttcttcgacg caagcacgta tgatatgtca gatgaaaatg tgattaatat 721681 ggggcttaag gataagccgt tctttacaga atcgattcca aagcttgaat ctcttaaaca 721741 gccattttat gcgcatttga ttacattgac aaaccattat ccgtttaacc ttgatgaaaa 721801 agacgcgtct cttaaaaaag cgacaacagg cgataacaca gttgacagct acttccagac 721861 agcgcgttac cttgacgaag cgcttgagca attcttcaag gagctgaagg aagccggcct 721921 gtatgacaac tcagtcatca tgatttacgg tgaccataac ggtatttctg aaaaccataa 721981 ccgagcgatg aaagagattc ttggaaaaga gatcacagat tatcaaaacg cacagaacca 722041 gcgtgtgccg ctgatgatcc gcgttcctgg caaaaaaggc ggagtgaacc atacgtatgg 722101 cggcgaaatt gacgtcatgc cgacacttct gcacttagaa ggaattgatt ctcagaaata 722161 tatcaacttt ggtactgatt tattctctaa agaccacgac gatacggtgg cattcagaaa 722221 cggagacttc gtaacgccga agtacacatc agtcgacaat atcatttacg atacgaagac 722281 aggtgaaaaa ctgaaagcga atgaagaaac gaagaatctg aaaacaagag tgaaccagca 722341 gctgagcctt tcagacagtg tcctgtacaa agacttgctg aggttccata aactaaatga 722401 tttcaaagcc gttgatccgt cagactatca ttacggcaag gagaaagaaa tcaaataaga 722461 tgaaaaagag ccttgagcgg gcgcattgcc ttcgctcaag gctctttttt tggttataca 722521 accaacttga aaaaatagat tccatttggt caccaaggct ggctttctct catatcatta 722581 cagtagattt tgaaaccgga ttgaaatcgg acaaattatc ggggaaatgc cttgatagat 722641 tgtgaagatg taccaggttt cgaactcaat attcatagag atgaggggta gagatgaaag 722701 cggtcattct ctgcggcgga aaaggaacga gaatgagtga agtcacgaat gacattccta 722761 aaccgctcgc catgataggc ggcaaaccga ttctatggca tattatgaaa atttatcagt 722821 actacggagt aaacgagttt attctgcttt tgggctataa aggagaaaaa atcaaggaat 722881 actttctcga ctatgaatgg aagcacaaca gcctgacact cgacagctct acgggagagg 722941 tacagatgct ggggcagcct gaaacgtgga aaattacgtt tttggagact ggggtagata 723001 cgctgacagc cggaagaatc ttgcaggcga aagactatat cggtgatgaa acatttctgc 723061 tcacctatgg agacgggctg gccaatatca atcttttcca tctcatcagc tatcatcaga 723121 caaaaggtgc tgccgcgact gtcaccggca ttgacaaagt ctcgcagttt ggcaccttga 723181 cagttgagga tggcatggcg aaaacatttt ctgagaagac atcaagtgat ggaatcatca 723241 acggcggatt cttcgttctt agtccaaagg ttttcgatta tttgccgaag gacgggaaca 723301 cgatgttcga agatgaaccg ctgaagaacc ttgccaaaga tggggagctt gctgtgtacc 723361 gccattacgg attttggacg gccatcgata cgtataaaaa tctcttagaa gtcaacaaaa 723421 tgtggaatca aggacaacaa gtatggaagg tatggtgaat tgatttgagt ttctggaaaa 723481 ataaaaacgt atttgtcacg ggatgcacag gtcttttagg aagctatttg gtgaaagagc 723541 tgatcgaaca gggcgcaaac gttacggggc tagtcaggga tcatgtgcct caatccaatc 723601 tttatcaggg agaacatatc aagaaaatga acatcgtgcg gggctctctt gaggacttgg 723661 ctgtgattga acgcgcgctt ggcgagtatg agatcgacac agtctttcat cttgctgcac 723721 aagcgattgt cggcgtggca aaccgcaacc cgatttctac ctttgaagcg aatatcctcg 723781 gcacctggaa tattctcgaa gcctgccgca agcatccgtt aattaagcgg gtcattgtcg 723841 cttcaagtga taaagcttac ggcgatcaag aaaaccttcc atacgatgaa aacatgccgc 723901 tgcaaggcaa gcacccgtac gacgtctcaa aaagctgcgc agatctgatc agccacacct 723961 attttcacac gtacgggctt ccggtctgca ttacgcgctg cggaaactta tacggcggcg 724021 gagatttgaa cttcaaccgc atcattcctc agacgattca gcttgtgctg aacggggaag 724081 cgccggaaat ccgaagcgac ggcacatttg tacgggacta cttctatatt gaagacgccg 724141 ttcaggctta tctgcttctt gcagaaaaaa tggaagaaaa caatcttgcc ggagaggcct 724201 ttaacttcag caatgagatc cagctgaccg tacttgaact ggtagagaaa atattaaaga 724261 aaatgaacag taatctgaaa cctaaggtgc tgaatcaggg aagcaatgaa atcaaacatc 724321 aatatttatc cgcggaaaaa gcaagaaagc tgctgaattg gacaccggcc tacactattg 724381 atgagggact tgaaaaaacg attgagtggt atacggaatt cttcaaaaag taatgtgaaa 724441 cgaggtgaac aagactgtga ccagcgcgta ttgcaccgtt ttatcaaaag gaagattata 724501 tcaggcagtc gctttgttta agtcgttaga gcaagttgat caagacagtc ccatttttat 724561 actttgcatg gatgaagata cgcaccgcgt gttacagaag ctgaagatga agcagctgaa 724621 ccttgtgccg gtggccgctc ttgaaaatga attgctgctg aagctgaagg aaactagaga 724681 tcaaagtgag tattgctgga cgatgaagcc gatctttctg caagctgtgc tgaacagcaa 724741 tcctgagctg gagcgtgtga cgtatattga cggggatctc tttttctatg cagatccatc 724801 gccgattttt gaaaaccagc cggactgctc ggtgttgctt tcacgagggg atattgtaat 724861 cccttctttt gagaaagagc agattgacat gctgcagcgt cttttaggca gatataattc 724921 cgggtttatc agcttcaagc atgatgatgc aggcacggat tgcttggagt ggtggaagga 724981 acgctgtctt gaggaatgca aaaatgcacc gggtgaaggg aaattcggtg atcagggcta 725041 tttggattat atgtctgagc tgtttccgaa tgtgtgtgac attacaacac ccggcgtgaa 725101 catcggccat tggaattatg gacagcatac gttttcctgg aaagatggcc ggatcgtgct 725161 ggaggatggc agtccgctga tcttttatca tttcagcgga taccgaatcg tcagcatcaa 725221 tgaaatcaaa cagattcatg aaacaacccg cacagatctg ccgtttgtgc atgaactgta 725281 tcaagagaca ctgccgcata tcattcagca catgcaaacg ttagaccctg aatttaacgg 725341 ttttgcttca aaagatgaca acaaataaat gagtaaatac aggaagtgaa aatgaagtga 725401 aagcaagcgt tattattcct gcatataatt cgaaggagcg tctttacaac agccttctgt 725461 cattaaacca gcaggagtgc gatgaagaat ttgaagtcat tgtagcggac aatggctctg 725521 aggacgggac gctctcgatg cttgagtcat ttcaagctga ttttccgctg atctttacac 725581 ggattaaaga aaacaggggc attgcgtacg gacgaaatca ggcgcttcgc aatgccagag 725641 gagacatcct gattttccat gacagcgata tgcttgcggc aaaggacctt gtggcaaaac 725701 atattaaagc ccatgagaac gaagagaatc tcgtcgtgtg cgggttgttt tggaaacgga 725761 tctacagttt ttactatgaa cgatttgaag aagaacataa ggaacagctc gcaaagctca 725821 caggtgaaat gccgaagaaa gacaaacaaa agctgctgga ggaagcggac atcaaaaacg 725881 gaagctttct tgataaaagc tttgacctcg ataccgactt tatagacgtg ctcaagaaga 725941 ttttagatga gtacggcgat gacttgaaag gctatcatat gccatggcgc ttttttatca 726001 cgaataattc ctctgtgaaa cgcaagcatg tggttgacct cggtttattt gacgaaggca 726061 ttgtgcggta cgggtttgag gattatgacc tcgggatcag gcttcatcag gccggattga 726121 ccttcaggct tcgccgtgat attgtcagtg ttcatcagga acatccaagc aattgtaagt 726181 ctgtagacga tattcgggca aacattgcct atatgtgcga taaatacaat aacatccgct 726241 ccttagacgt tcatctcgct tttaatgggc cgttcccgcc tgacatgacg aacagaatca 726301 tggctgatat tcaaaagctg ctggaatcac agaaatatga tatgctgctg aatctgtttc 726361 ttgagcttct gcatgttgtt aaagagcgca acattgatcc ggattggcga aagaaatccc 726421 caagggtgac ggcgaaaagc tttgatttgc aaactgtccg caagcttctg cctaaggcga 726481 agaaaaagct aggcgtgaac gattttgcca acgcactgta tgcgcttgtc aacgatttgc 726541 tgcacgtgga tcttagatca ttggatgtgg tataagtgag tacatttcat ttttcaacga 726601 tagtgtcaag gacacatatc tttaagctca tgcctatgat tcattctctc catgagcatt 726661 gcgatgattt tcatttatat gtgctgtgtg tcgaccagaa agcgtatgaa ttgcttcagc 726721 acgttccatg ggagcatgta acctttgtgc agctgcatga aatggaagac ccggagctgt 726781 tgaaagcgaa aagcaacaga acgtttcatg aatattgctg gacgttaaag cccgcctttt 726841 tgtttcatgt gatgagcaag tgggatgacg ctgaatactt tgcccatatg gatacggatc 726901 tatttttctt ttctgatccg gcacgtattt ttgcagaaaa cccaacggcg tctctgtatt 726961 tgactgatca tcgtaattcg ccgcgcttca tgtcctacta cgaccgaacc ggacgcttta 727021 atacaggctt tgtcggcgcc ggtaatacaa aggaagcata tgaagcggtg tggcagtgga 727081 gacaggactg tattgaattt tgcacggtcg aaatggatac ggaacgaaag acatatggtg 727141 atcaaagata tgtggagaaa tggccggagc agtttaaagg tgttcatgtt gtcaaatcca 727201 taggagccaa tacagcgctt tggaatatcg aaaactataa ggtcgggcaa aaggacggcc 727261 gcgtgtatat agatgaaacg ccgctgattt tctatcattt ctctgggttt acgctggtga 727321 cagaaaaaga gtttaatctt tgctggtact accggattga agacgaagcg acaattaaga 727381 tgatttatat gccctatata ttaaatctga aaagatggat tgatgaaata cagtcggcgt 727441 ttccggactt tgcggatggc tttatcccga agcacgcagt gcctgacact cattttatcc 727501 agctggatta aaaaaccccc tgccgcctgg caggggtttt ttcagctatg ccattctctc 727561 agcttctggt cacttggcaa taggaaggca aggatgccga ggacagggag aaaggcaatg 727621 gcgatcatcg tcggggtcag tcccgcggca tcaatcagag cgcccagcgc cacagcgccg 727681 attgcgccca tcccgaaggc aagcccgacg gttaaaccgg acattgtgcc gatttttcca 727741 ggaactagct cctgtgcgta gacgaccgtt acagaaaagc tcgacatcag aaccaagcca 727801 atcaatgcga gcacgccgta ggcgagaacc gggccggcaa atggcagcac aatcgccagc 727861 ggcgccgagc ataacagcga accgaggata acgaagcgtt ttccaaaacg gtctgcaagc 727921 gggccgccga gaaacgtgcc gatcgcgccg aacagcaaga agacaaaaat atagctttgt 727981 gcctgctgaa tgcttacgtg ataggtatcc atcgcgtaaa acgtgtaaaa gttaccgatc 728041 gcactcgtat accaagaacg agcaaaaatg agaaatataa taataataag agcagataca 728101 acagatttgg tgatggccgt gttttcagcc gttttctttt gcttgcctga tttctgggca 728161 aggctgccga gacgtgaggc gtaccatttc gcaatataca tgagaaacat aacagcaagc 728221 gcggcgacaa gcgtgaacca aacagcgccg aattgcccga gcggcacaag gatcagcgcg 728281 gtgatcagcg gtgccatcgc ctggcctgag tttccgccca cctgataaat cgattgggcg 728341 agcccgcgtt ttgtgccggc ggccatatac gccacacggg agccctccgg atggaaaatg 728401 gccgagccta atccaatgaa aaacacacag cataagatcg ttatgaatga cggggcaaat 728461 gcaaggccca aaatgccaag catgctggcg gtcaaaccga ctggcagcgc atacggccgc 728521 ggccgtttat cggtatacca gccgacaaca ggctgcatga cggatgacac catgtttaat 728581 gtgaaagcaa tgatgccgag ctgtgtaaac gtcaggctca tggagcgttc caaaataggg 728641 aacatggccg gaatcacagc ctgaagcgaa tcgttgagca tatggcaaat tccgataata 728701 atcaaaatcg gatacaccgt ggtgcctggt ttttgaactg ttttttcttt taacggggcg 728761 gcgatagcca ttgagtctcc tccttacata tataaccaaa gcataccacc atattattca 728821 taaggtgaag aatttatcaa gaggaaaaaa gattcttatg aaagaaatac cgtcagcctg 728881 attagcagct gacggtattt tcgatattca aaatgtgata tagctcttca agcttacgaa 728941 tctcataggt tggtatgatc tctggcacat tcggcttcat gtcagggttc atccagcaag 729001 tatcaagccc ggcgagctgt ccgcctttga tatcagcagt tagtgaatcc ccgatgatta 729061 atgtgtgctc tgctgaaaat tgaggaatcc gttcaaacac gtaattgaaa tattccttca 729121 tcggcttttg gaagccggtg tcttcagaaa cgaaaatgtc cttgaagaat ggaaataatc 729181 ctgaatcacg gagacgctta tattgtgtgt gagacacgcc gtttgtcacg atgtacaaat 729241 caaactgttg ctgcagattt gagatgagat caaatgcacc gtcaataagc tgatgtcctt 729301 cttcaagaaa gcggcggtat ttttgctcaa gcaaagcgcc gtccgcttcg taaccgtact 729361 ccttgagcaa agcggaaaaa cgtgtgttta cgacttcatc ccgtgtcatc ttaccttctt 729421 caaaggctct ccagagacct tgattgatgg ttttatactg cgccttcatg tcatttgtta 729481 aaggaatgtt ctgatcttca aacagcaaac gcagggctaa agcttctgcc gcttgaaaat 729541 caaggatggt atcatctaca tcaaataata aagtgcggta tcgcttcatc tgtgtgtctc 729601 cctttctcat atgtattcaa agtatagcac ataaaaaaag gaaaaagccg gcgggtgagg 729661 caccgccggc tgaaaagaga ttatttgttt aataagctgt gttttctcga atataggaag 729721 taaaccagcg ttccgacagc gatccagatg acaaatgaaa gccatgtgac gccgggaagg 729781 ctgtacatga accaaaggca gatgcctgcg ctgataatcg gcacaaccgg aacgaatggc 729841 actctgaagg acgctttgat ttcaggatgt ttctttctta acacaatgac agcaatggaa 729901 atgaccgtaa acgcggcaag tgttcccatg ttcaccagat gggccagcgt tccgaggtta 729961 ataaagccgg cgattcccgc tgcaacgatc cctgtcagcc atgtgttgcg gaacggggtt 730021 ttaaatgacg gatgaacctt tgcgaacaat ccaggcagaa ggccgtctct gctcatggca 730081 aatgtcaagc ggacctgtgc gtacagcaaa gcgagcatca ccgtcgtaat cccgataatc 730141 gcaccgacag aaataattcc ggcaacagcg tcctgtccga cgaatttcag cgcaaaggat 730201 acaggatctc cgacattcaa tttggcataa ggcatcatgc ctgtcagcac aagcgatacc 730261 gcgatgtaca gaaccgtaca gacggctaga gctgaaataa tgccgacggg catgtttttt 730321 tgcggatttt tcacttcctc tgatgcgtta gaaaccgcgt caaacccaag gtacgcgaag 730381 aatacagtgg cagcgctaag tatgacgcct ttcatcccga atggcataaa aggagaccag 730441 ttatccggtt tcacatagcc gatgccgaca ataatgaaca ataatatgat cgcgattttc 730501 atcagtacga tgacgttgtt aaagcgtgtg ctttccttga cgcctctgct gacaatcgca 730561 gtgatgagga gaatgatcac cgcagccgga aggttaaata cggcgcccgc catgcttccc 730621 ggcgctcctg tcagtgcagc cggaatatga agattgaagc cggcaagcag tgattgaaag 730681 tatgaagacc agccggtggc aaccgccgac agtgcaatga catattcaag catgagatcc 730741 catccgatca aaaaggcgag cagctctcca agtgtcacgt atgagtatga gtacacgctt 730801 cccgaaatcg gaatggaaga cgaaaactca gcataacaga aagcagccag cgcacaggcg 730861 agccccgcta aaataaacga tatgatgagg gcgggacctg caccggtcgc tgccactgtt 730921 cctgtaatga caaaaatccc tgtaccgatg acacaaccga taccgagcaa ggttaaatca 730981 aatgcgctta acgtacgggc aaggcttttt gacttgctct gcgcactcaa tgtttcaagc 731041 ggtttttttc taaataatga actcatcaaa agttcctcct agaaatattc aaaatattct 731101 aatcattata tgcagttctt gttgtattat attgtcgaaa tttgacgtag tcaataaaat 731161 atttttctgc tttaaatgat agaagcgaaa cagcgttgtc gtatcatagg atagtaattt 731221 ttactaatcg tatattcaat tttatgcaag atgaaccgat agaaaaaata gattcgccca 731281 tattttgatt tgcggttata aaggagatgc tgaccatgtt tcaatatgaa gagttgaata 731341 aacagtttat cggcgggaaa tggcaggagg gcagcagccc aaatgtattg gaaaacaaaa 731401 atccttatac tcaaaaaaca ttcacaacat tccgtaaagc gactgctgac gatgtagatg 731461 aagcgtatcg ggcagcggcg ctggcaaaga aaaaatggga tgcggtcaac ccgttcgaga 731521 aaagaaccat tttagaaaaa gccgtcacgt atattgaaga aaatgaagaa gccattattt 731581 atttgattat ggaggagcta ggcggtacaa ggctcaaagc agcttttgaa atcggtcttg 731641 tcaaaaacat cataaaagaa gcggcaacgt tcccaatccg catggagggg aaaattcttc 731701 cgtcaacaat agatggcaag gaaaacagat tatatcgcgt gccggcaggc gttgtcggtg 731761 tcatcagtcc gtttaacttc ccattctttt tatctatgaa atcagtggcg cctgcactcg 731821 gagccggcaa tggcgttgtg ctaaagccgc atgaggaaac gccgatttgc ggcggaacgc 731881 tgattgcgaa aatttttgag aacgcgggaa ttccagcggg gctgctgaat gttgttgtca 731941 cagacattgc tgaaatcggc gacagcttcg ttgagcatcc agtgccgcgg atcatctcat 732001 ttaccggttc tacgaaagtc ggcagctaca tcggacagct tgcgatgaag cattttaaaa 732061 agccgcttct tgagcttggc gggaacagcg ccttcatcgt acttgaggat gcagatatag 732121 aatatgcggt caatgcggcg gtgttcagcc gatttacaca tcaagggcag atttgcatgt 732181 cagccaaccg cgtgcttgtt cattcttcta tttatgacaa gttccttgag ctgtaccagg 732241 caaaagtgga atcgctgaaa gtcggcgacc caatggaccc tgatacgatt atcgggccat 732301 taatcaacag cagacagacg gacgggctga tgaagactgt agagcaagca attgaagaag 732361 gcgctgtacc agtgaagctt ggcggattta acgggacgat cgtggaaccg acgatcttaa 732421 aagacgtcaa accgttcatg agcattgcca aggaagagct gttcggacca gtcgtctcct 732481 ttatgaagtt tgattcagaa gacgaagcgg tggatatcgc aaacgaaacc ccgtttggct 732541 tgagcggtgc cgtacatacg tcaaatcttg agcgcggcgt ggcttttgcg aaacgcattg 732601 aaacaggcat gattcacgtc aatgacacga ccatcaatga tgaaccgaat gtagccttcg 732661 gcggtgaaaa gcaatcaggc ctcggccgtt taaacggtga gtggagcctc gaagaattta 732721 caacgctgaa atggatctcg gtccagcacg aaaaacgcag cttcccttat taatgaaaag 732781 gagtgaatgg aattgaccat aaatacggaa aaagaaaccg cagatattct ggacgcattt 732841 atcaaagtag ccccttattt aaacagcctg gttcaggatg atattacaat cggcatttat 732901 gatacggaaa aactgctcgt gaatataccg gccaaaacct tttcgctgaa cgtaaaagcc 732961 ggcgatccgc tgcaggaagg ggatatcatc acagatgcca tccgcagcaa tcagaagaag 733021 acgagcatgg ttccgaaaga attgttcggc ttcccattga tcgcgcgtgc catcccgctg 733081 cacgacgaga atggaagagt cattggaggc gtcggcctcg gaacgagcct tgaggagtcg 733141 tcaaagctgc atgatgtcgc ggaaagctta tcagctgttg ttgaacaaac agccgcggct 733201 atttccgaca tttctgaatc aattaacggg ttttcaactc aaatgtcggg catttcctct 733261 caggcgaaaa aagtaagcga aagcgccggt gaaatcgccg atatttcagt aactgttaaa 733321 ggcatctcgg accaaagcaa tctgctcggc ttgaacgccg cgatcgaagc ggcaagagca 733381 ggggagtccg gaaaaggatt ctctgtcgtc gcagatgaga tcagaaagct agcgacgcat 733441 tcaaaagaaa atgtcggcca aattgaccag attacgaaaa aaatccacag cctgctgaaa 733501 gggctggagg aatccattga gtcgattaac cagcatacag acggacaagc cgctgctgtt 733561 gaacaaattt ccgccacgat gcaggagatt tcaggaagcg cgcagcatct tgcgaaaatg 733621 gccgaaaaag cgcttgagga agagtaagag accggggaca aacatccccg gtctttttct 733681 tatcctgcat ttccatgaaa ttcgtctgac gttttactag ttttattcca gcggctgatt 733741 taaaatgtac acatgaactt acgtgaggat tgataggaac catgagcata ttaaaagcgg 733801 aaaatcttta taaaacatac ggagataaaa cattatttga ccatatctcc tttcatattg 733861 aagagaatga gagaatcgga ttaatcgggc cgaacggaac aggaaaatca acgctgttga 733921 aagtgattgc cggcttggaa tctatcgaag aaggagaaat cacgaaatcc ggaagcgtgc 733981 aggtcgaatt tcttcatcaa gacccggagc tgcctgcggg gcaaacagtg ctggagcata 734041 tctattccgg tgaatcggct gtgatgaaaa ccttgcgtga atatgaaaaa gcgctgtatg 734101 aactggggaa agatcccgaa aatgaacagc gccagaaaca cctgctggca gcacaagcga 734161 aaatggacgc gaacaatgca tgggatgcaa acaccttggc aaaaaccgta ttgtctaagc 734221 tgggcgtcaa cgacgtaaca aaaccggtca atgagctctc aggcggccag aaaaaacggg 734281 tggccattgc caaaaactta attcagcccg ctgatttgct cattttggac gagccgacaa 734341 accatttgga taatgaaacg attgagtggc ttgaagggta tttaagccaa tatcccggcg 734401 ccgtcatgct ggtgacgcac gatagatatt tcttaaaccg tgtcaccaac cgcatttatg 734461 agcttgaaag aggcagcctc tacacttaca aaggcaacta tgaagtgttt ttagaaaaac 734521 gcgcggaacg ggaagcgcag gctgagcaaa aggaaacgaa gcggcaaaac ctgctgcgcc 734581 gcgaactggc ttggctcaga cgaggagcga aagcccgctc cacaaaacaa aaagcgagaa 734641 ttgaccgggt agagacgctt aaagagcaga caggccctca gtcatcaggt tcactcgatt 734701 ttgccattgg ctcgcaccgt ctcggaaaac aggttattga agcggagaac gtcatgatcg 734761 cttatgacgg ccgcatgctc gtcgaccgtt ttaatgaact tgtcatacca ggtgaacgga 734821 tcgggatcat cgggccgaac ggcatcggga aaacaacgct gttaaatgcc cttgccggcc 734881 gtcatacgcc ggacggaggc gatattacga tcggacagac ggtcagaatc ggctactata 734941 ctcaggatca tagtgaaatg aacggtgagt taaaagtcat tgactatata aaagaaacgg 735001 cggaggtcgt aaaaacggca gatggcgata tgattacagc tgaacaaatg ctcgagcgtt 735061 tcctcttccc gcgttcgatg cagcagacgt atatccgcaa gctgtccggc ggggaaaaac 735121 gccgtttata cttgcttcag gttctcatgc aggagccgaa tgtcctgttt ctcgatgagc 735181 cgacgaacga tttggatact gaaacattaa gcgttcttga ggattatatt gaccagttcc 735241 caggcgtcgt catcaccgta tcccatgacc gctatttcct tgaccgcgtc gtcgaccgtt 735301 tgattgtatt tgaaggaaat ggtgtcattt cccgctttca aggctcctat agcgactata 735361 tggaggagtc aaaagcgaaa aaagcggccc caaaaccggc agctgaggaa aaaacggctg 735421 aagccgagcc gaagaaaaaa cggaaaaagc tttcttacaa agaccagttg gaatgggacg 735481 gcatcgaaga taaaattgcc cagctggaag aaaagcatga acagcttgaa gctgacatcg 735541 ccgcagcagg cagtgatttt ggcaaaatcc aagagctgat ggccgagcag gcgaaaacgg 735601 cggaagagct tgaggctgcg atggaccgct ggacagaatt gtccctcatg atcgaagaac 735661 tggaaagcta aaaagcgtgg ccgcagcagg ccgcgctttt tttcacataa tggacaaaaa 735721 cgaaccggcc tgcttatgtt aggataaagt tgtgtgtcag cggcacatgg aaaactaacg 735781 gagatgatga agtatgacat gggcgatcgt gatgttaatt ctcatgagtc tggtgaaaat 735841 cgtattaacc tgtcttccta caggcgtcat agaatggctg ctcggcaaat ttgaagtgca 735901 cgccaagctg agtgacgaaa atgcgagtct ctctctagat ggaaaacgcc tcgagggtgc 735961 agagaagcag aaagtgattg atcaatttaa cgaagctatc ttcctggaaa aatattatat 736021 ctatccaggt gatgaagagc gttatttaca tccggaaaac ggcggcacgc ctctggtgat 736081 agatacaaaa aaaggaaaaa aagacgtgaa gctgttcgtg taccgctacg acgaccatat 736141 cgacgtcgtg aaacagtaca agaagaaagt gatcgcgtat cgagtgcttt ctgaaagcct 736201 tcaaaaagag tctctgtcag tggcgggaag tttagcttaa acaggaaagt gaaagacggg 736261 tgctgtatgc tgctcgtctt ttttattgtt ttttaaaact taacgtttac gttaaggttc 736321 aaaaggtgta taatggtaac agaaacggcg aagggggatt taccttggaa tggatgaaga 736381 ttgatcaagt ggccaaaaga agcgggctga caaagcggac catccggttt tatgaagaaa 736441 tcggcttgat tccggcgccg aaacggacag acggcggtgt aaggctttat tcagaggatg 736501 atatggagga gcttgagaaa gtcatcagca caaaagaggt gctcggtttt tcccttcagg 736561 agcttcagca tttcatggaa accagccgcc agctagagtt aaacaaagag gggtatttgt 736621 tgtcactgga tcctaaggaa cggaaagaaa aactggagga aattcaggaa accctgaatc 736681 accagctgga tttgattgat gagaaaatcc gcacattcca aagctttaaa gaacgcctgc 736741 agggcatgaa aggcaaagcg gaacgcgcca ttcaatcaat cgaatgaaaa gtttgttaaa 736801 cgctattttt gtagcgtttc ttttaatgga ataaagatgg aggttaggtc aaatggataa 736861 gacaacacaa gtgaatcaga aaacgggttt gctcagccag ccaaaagcgg tatgggctgt 736921 cgcgtttgcc tgtgtgattt cttttatggg aatcgggctg gtcgatccaa ttcttccggc 736981 cattgccgca caattgcatg cttcacctag tgaagtatca ctcttgttta caagttattt 737041 gcttgtaacc ggatttatga tgtttttctc aggagccatt tccagccgca tcggcgcgaa 737101 atggacatta attctcggac ttatttttat tattgtgttt gcggggcttg gcggcagctc 737161 aagctcaatc gctcagttag tcggctatcg cggcggctgg ggattaggga atgctttgtt 737221 tatttcaaca gcgcttgcgg tcatcgttgg cgtgtcagtc ggcggcagcg cccaagcgat 737281 tattttgtat gaggccgcgc tcggtctcgg gatttctgtc gggccgcttg caggcggaga 737341 gctcggaagc atttcatggc gcgcaccgtt ttttggagta tctgtcctga tgtttattgc 737401 gttaatcgcg atttctttca tgcttccgaa gctgccgaaa ccggcgaaac gcgtcggtgt 737461 gtttgatgcg atgaaggcac tcaaatataa aggcctgctg acaatggcgg tatcggcatt 737521 cctatacaac tttggatttt ttattttgct agcttattct ccgttcgtac tggatttaga 737581 tgaacacggt cttggatatg tcttcttcgg ctggggcctt ctgctggcga ttacgtcagt 737641 ctttacggcg ccgctcgtgc acaaagcgct gggcacagtg cgttcgctag tcgttctctt 737701 tatcgccttt gcggccattc tcgttattat ggggatctgg acagaccatc agactttgat 737761 tattacatgt atcgttgtcg ctggtgctgt cctcggtatg gtgaatacga tcatgacaac 737821 cgctgtgatg ggttctgcgc cggttgaacg ttcaatcgcg tcttcagcct acagctcagt 737881 ccgcttcatc ggcggcgcgc tcgccccgtg gattgcagga atgctgtcag aacactttac 737941 tgcaagcaca ccatatacag taggcggaat cgtcgttttt gtcggcatgc ttgtccttct 738001 catgggacgt aaacatcttg ctggaattaa ggcggggcat taataacgaa agacactgcg 738061 catatgcagt gtctttttat tcgttataat gcatcataat cgaattggtg caggaaagga 738121 caacctttat gacacaattt tactattttc cggctgaaaa ctccctttag aaaccggttt 738181 tttcggtcag caagaacggc gttcgcggaa agggcatccg cttcggtcag gcattgatgc 738241 ggctgggatt tatcttgcag aagctgagaa tgtgtccgtt catttacgat tgccatttca 738301 gtgatggttc atgctgtaga ggggacgttt gccatggata aggcaaaacc tgacgaatat 738361 gatcagaaat gtttagaaac gctctatcaa tacatacaca gcgtcatgaa aaacagcttt 738421 tctcggtcga gtggtttacc gcttgggaag atgaggagga ttttgagctg tctgccaaaa 738481 gagagctgac acttgatgaa ttcacatctc cattgcagct cattttaaaa gacagagagc 738541 ttttgagaat cgttcagaaa aaatggcagt aaaaaacccg ccctttagca ggcgggtttt 738601 tttataaatt aaagcacttt cgtcgtccaa gactcgcagt tccacgtttc tgtcgcaata 738661 tccatataaa agtctggctc gtgggaaatg agcagaatgg agcctttata ttctttcagg 738721 gcgcgcttga gctcttcctt ggcatcggca tccaagtggt ttgtcggctc atcgagcacc 738781 agcaggtttg tttctgagtt gattagcttg cacaatctga ctttcgcttt ttcgcctccg 738841 cttaatacgg agacgcggct ttcgatatgc tttgtcgtca gcccgcattt tgccagagcg 738901 gcacggattt catactgcgt ataagaaggg aattcgctcc atacttcttc gatgcacgta 738961 ttgttgtttg tttccttgac ctcttgctcg aaatagccgg tatagatgtg ctcaccgcgt 739021 tcaacagagc cttcgagcgg ctggatttca ccaagcaaac ttttcagcaa tgtcgttttt 739081 ccgatcccat tcgcgccgta aagggcgatt ttttggccgc gctccatgcg gaggttgagc 739141 ggacgggaca gcggggaatc gtaaccgatc acgagatcct tcgtttcaaa aatcagcttg 739201 cctgacgttc tcgccggctt aaagtggaat tccggctttg gcttttctgc cgcaagctcg 739261 atcatatcca tcttatcgag tttcttttgg cgggacatcg ccatgtttct cgtgctgaca 739321 cgcgctttgt tgcgggcgac gaaatccttc agctccgcga cttcctgctg ctgctttttg 739381 taggccgctt caagctgctg ttttttcacc tcgtagactt ccataaactg atggtagtcg 739441 ccgacataac gtgtcagctc ttgattttca acgtgataaa tcaggttgat gacactattc 739501 aagaacggaa tatcgtggga aatcaggatg aacgcgttct cgtattcctg caggtagcgt 739561 ttcagccatt caatatgctg ttcatcaaga tagttggtcg gctcatcgag aagcagaatt 739621 tccggctttt caaggagaag cttagcgaga aggacctttg tgcgctgtcc gccgctcaaa 739681 tcggtgacat ctcgctctaa accgatatcg ctcaaaccga gaccgcgggc gatttcttcc 739741 accttggaat caatgacata aaaatcattg tttgtcagcg cgtcttgaat gacgccgact 739801 tcttcaagca gcttctcgag ctcgtcggga tcagcctcgc ccattttgtt gtaaatctcg 739861 ttcatttcct cttccatcgc aaataaataa tggaatgcgt ctttcaggac gtcgcgaatg 739921 gattttcctt tttccagcac ggtatgctga tcaaggtatc cgacacggac attttttgac 739981 cattcgactt ttccctcatc aggttcaagc tttccggtaa taatattcat gaaggttgat 740041 tttccttcac cgtttgcgcc gatcaagccg acgtgctcgc cttttaacag gcggaaggaa 740101 acgttattaa aaatggcccg gtccccgaaa ccgtggctta aatcctttac agataaaata 740161 ctcatgttta cacctctatc gttatcaaac acgcacaatc ggcgtgtaat attcaccctt 740221 ttgattataa aggaggattc ggaatgttga aaggtatagg aaagaaaaag aaaaattgcg 740281 ttccgggcga ggttttgaga tactatggaa tagatttcag gaattgagga gaacaaaatg 740341 acgcaaactt ggccattttt acataatgca caatcattta tacaagagaa ttggaatgct 740401 tccggctttc aaaagccaac ccctgttcag gagcaggcag cccagctgat catggacgga 740461 aaggatgtca ttgcagaatc gccgacaggc acagggaaga cgctggcgta tgcgctgccg 740521 gtcttggagc ggatcaaacc agagcaaaag catccgcagg cggtgatttt agcgccttcc 740581 cgtgagctgg tcatgcagat ttttcaggtg attcaggatt ggaaagcggg ctcagagctg 740641 cgcgcggctt ccttaatcgg cggggcgaat gtgaagaaac aggtcgaaaa gctgaagaaa 740701 catccgcata tcatcgtcgg cacgccaggc agggtgtttg aactgattaa agcgaagaaa 740761 ctcaaaatgc atgaagtgaa aacgatcgtg cttgatgaaa cggatcagct cgtcctgccg 740821 gagcatcgcg aaacgatgaa gcaaatcatt aaaacaacat taagagaccg ccagcttcta 740881 tgtttttctg ccacgctcaa aaaggaaaca gaggacgtgc tccgcgaatt ggcgcaagag 740941 cctgaggtgt tgaaggtgca gcgaagcaag gcggaggcag ggaaagtgaa gcatcaatac 741001 ctgatttgcg accagcgcga caaagtgaag ctgctgcaaa agctgtcaag gcttgaaggc 741061 atgcaggcac tcgtatttgt gagagacatt ggcaacctga gtgtatatgc ggaaaaactg 741121 gcatatcacc acgttgaact cggcgttttg cacagtgaag cgaaaaaaat ggagcgagcg 741181 aaaatcattg ccacattcga agacggagag tttcctcttt tattggcgac tgacattgcc 741241 gcacgcggtt tagatattga aaacctgcca tacgtgattc atgctgatat tccagatgaa 741301 gatggctatg tccacagatc aggacgaaca ggccgggccg gaaaagaagg caacgtgctg 741361 agccttgtga caaaattgga ggaatctaag ctgaaaaaaa tggcgaagaa gcttggtgtt 741421 gagctgagtg aagctgtgta tgcaggcgga aaactgaaga cgaaataaaa agaagggcga 741481 agagcccttt ttttgttgta aaataataga aaagattttg cgcggaggtg ggaaaatggc 741541 ttcaatagac aggtttcaag taatgcagga gccagagctg aaaatccttg aacactggtt 741601 tgagaatgag gataccagac ggagaatgga tgggatgctg ctattagatg agtggtatgc 741661 acgagtaaat aaagataaac acgatactgt catcatggcg tatgatggac agctgccggc 741721 agggatggtc gttattgagt tcggagagga gcggacatat attggattga tcgtcaatcc 741781 tttgtaccgg cttaaagggt atggaaaaca gatactgcaa aagctgatga ccgaacctga 741841 ttttactagc gtgcgagaat gggtggcatg cattgaagaa gacaatcgaa tcagtttagc 741901 ttgctttcaa gcagcaggat tcactttaga agacacggaa cctgatgaag atggttttct 741961 tacgctgatt cttcgcaact gatctcatcg aaacacaaaa ggagggcaaa aagccctccc 742021 gttttcatct tcattcagct cggatcactg accttgatca gctgtttccc tttattttct 742081 cccttaaata aaccgagaaa cgcgtcagga atgttttcga agccttctgt gatggtttcc 742141 tcgtaatgga gtttaccagc cttcagccat tctgccagct gttttgctcc ctcagaaaaa 742201 cgatcggagt agtcgcttac gataaagcct tgcatcagcg acttcgtttt aatgagtttt 742261 gattggacac gagggcccat gtcatctgct tcgctttctg cgttatagga agaaatggcg 742321 ccgcacaccg gaatgcgggc aaattcattg agcagattca tcaccgcgtc tgaaatcggt 742381 ccgccgacat tgtcaaaata cacatcgaca ccgtcaggac aagcgttttg aagcgctttt 742441 tggatatcat ccgctgtttt gtaattgatg gcttcgtcaa actgaagctc ctgttttaaa 742501 tagtcgattt tttcatcaga gcccgcgatg ccgacgactc gcgcgccttt gattttggca 742561 atttgcccga ctgttgaacc gacggctccg gcagctcctg agacaaccac ggtttcgcct 742621 tccttcgggc gtccgatgtc cagcaatccg aagtatgctg ttaagccggt cattcccaaa 742681 atgccgagat aggccgaagc gggagcaagg cttgtatcaa tttttcgcaa ggcagactcg 742741 ctcacagcgg aaaattcctg ccagctgaga tttccgatga cgatatcgcc ttttttcaga 742801 tgattcccgt ctgacacaac ttcagcgata acccctccag aaagcgcttt atccaaggcg 742861 aacggctcaa catatgactt cgtatcctgc atacggccgc gcatataagg gtcaaccgat 742921 acataaagcg ttttgacaag cacttcccct tgcttgggtt caggaaccgg aatggtttca 742981 aagcgaaagt cttcatgaac aggaatacct tgtggacgtc ttgctaattg aatttgctgc 743041 tgagatgctg tcattttcat cctcctatca cttggttgac accactgtaa catggacagg 743101 agaggaaata caaaaggtaa gctggcatac aaaaaaggtt atagatgagc ttatgctttc 743161 tacaagctct tttgttttaa aagttctctt tagtcattta tcattattag aaaacagaac 743221 agaaaaagag ctcctgtaca cctagctaag attggctagt gtgtatgtcg attctttttc 743281 atattcttgc aagcatctgc gagggggagc ttagtcgttc acattttgct ttcgcatcaa 743341 tctgcaatag caaagtctat gcgatttttt tacatcagca aagatttgtt caattttttc 743401 cttttatgcc gagtttttct gaaacagata attgatggta ctcaaccatt ttcttttggt 743461 caataaagta atgtttactt attaattaaa cacgcgaaaa agcaaacgaa aacataatta 743521 aattttatat atttattaaa agcttatatg tttatttacc ttttttttga attgtaattg 743581 agaaaatcca tatattgcgg acactaataa aagaatacct gctgaaacat aaactaaacg 743641 aactccaagg aaatctgaaa tagcccctat agccagaatt gaaaacataa aaatgaactg 743701 tactaaagaa gaccttgcag acattatatt aattcgagtt tgctcggttg ttatgttctg 743761 aataagtgtt tcttgtgtaa gatctcttaa tatataagcc ggccccataa agagaaccaa 743821 aattagagct aagtatgaat tacttataaa accatatatt aaagttaaac ttccatatga 743881 gacagcgcca attaacataa aattaattaa cttattttga aatctctccg acagcttata 743941 tattataaat ccccctatca tcgaacctaa ataatatgct ccattaataa atccccacca 744001 tgattctcct ttatgcaaga cttcgttaac gaaagctaaa gagacagatc ctatccaaat 744061 cattcctgcc catgactcaa ttaaatccat aataataatt gttctaagtt tcttttggct 744121 aaataaatac cgccaaccac ttactatact cttattggga gaattttttt cacgtatgac 744181 agaattagcg tggccatgtg gtagacaaaa taaaagagaa agaagagatg taaacaacaa 744241 aaagatagta agtataatgg tatatccctc acctaaaaat gcaattatga gaccacctaa 744301 agaccagcct acaaattgaa aagtttggtc cactgtagat aataatccat ttgcttttac 744361 tcttctatca ggagagatta tttcccctat aattgcactt tttaaaggtg agaaccatcc 744421 attaaaaaag gaaatacagc taataataat aaagactaaa atgagagttt gattagagta 744481 agttcttaat aaagcataga acaaacatat taataacagc atttgtatca attgagaaat 744541 aattattgta agaggcagtt ttaatcgaat tgttattaac ggtaatatag cacttccaaa 744601 aatacgaaaa ataatactta ttaatgtcac catagaggcg atggttgtcg aattggtcat 744661 tttaaacaaa aacgaaatca ctaccatagt atatagagaa aaacctaaat ttgtagtggt 744721 ctggctaaat aaaatagaat aataaccttt actcatatgt atcctccctt ggaataattt 744781 ttctcggtaa agagcttaaa catatttaaa caccttaaaa caacaaaagt aaagaaaaaa 744841 tttccttgta aactatttac ttttattcta tttattgtta ttgtttattt aagttctctg 744901 actattctat caatattcag ggaaccacat atcttattaa aggggggaaa accatgagaa 744961 aattaagaaa aaactggaga aaatcgattg ttagcccggt tctttatact aatgaaaaat 745021 ggtaaacact tagggaatag catttaatgc tattccttat ttcaacaaac aaatcgggag 745081 gttatcgtaa tttgactcta ttaatgcaag atcataaatc aatttacaat aaagatatag 745141 aaatattaat tgaagttgaa gaacttatta cttctgttcc agaaaataaa aaaaatgatt 745201 ttaagagttt aatcgataat agaattatga ctctactaaa taaaattcaa caccctgtag 745261 cagcggaaaa tgtgtttggg atgtgtattg cttatccgaa tacttacata aggtatagat 745321 taattgattt cgttgaaaaa tgggtacctt atttctctgc tgtagaaact ataatcaatc 745381 taacccagga tccggatgat ttagtttctt ttaaagctat ggatgtctgt gcaaatcata 745441 aaattgaaga atctgtagca tatttgtctt cgattattga tgatgtccgg gagagtataa 745501 gctaccctaa aaaacctgtg ggattagggg cccaaaaagt attaagtaca ttattagata 745561 tattcggtgt tgaaaaacat gaagagctag taatgctaaa aaattatttt gatcaaaatg 745621 gtatacttcc taataacttt gactttgaag aaaaaattcc tcaaagtcta atagaggaat 745681 tcgaaaaaac agaagaagat gggatgattt taattccggg tggctttttt gaattcggtt 745741 taaatgaaaa tgaaattcct gacaaaacat ttaattggaa agatgctgtt cctagacaaa 745801 aagtatggtt acctccattt tttatcgata agtatcctgt tacaaataaa gattatgata 745861 tctttaccga gttcatagag gaaaatgggc atatattctg tcatcctaat gaaccgcaga 745921 ataaacaaca tagaagaaat acatattggg atgataggta tttagataat catcccgtta 745981 caggtataga tttttatgat gcatttgctt acgcaagata taaggggaaa gaattgccaa 746041 ccgagtttca atgggaaaaa gctgctcgag gcgaaaaggg taatgtctgg ccttggggag 746101 ataaatttga tcctgcaaag gttcaatatg ctggaagtct ttataatgaa cccattactt 746161 ctttaaagtc ctggagagaa aatttattaa aagctcatgc tgataaagaa ttaaatcatt 746221 taacaagtga tatttttgaa caaaatggtg aaagtcccta tggagtatgc ggtatgatcg 746281 gcggaacatg ggagtggact agaagtgagc ttaaaacaaa gagagctttc caccctattt 746341 ttgagaatgt accatttaat agtgttaact catttgccgt tcttaaagga ggatcattct 746401 tctctcatcc aggcttaatg ttcccttctt ttagagcaaa agatattcct ttctgtcgac 746461 acaatgaaat ggggattaga tgcgtaaaga atattccagt atataaaatt agagaatcaa 746521 ttaatgggcc aattactaat aaagcaattt attaatcatt ctaggttaga gacttgataa 746581 aagtatacta acattgtgta gtaatgttca gcttgtagaa aaaacaatgt tttttctaca 746641 agattttatt ttaaatgctt ttcaaaatta tcagggattg agaatcagaa aaagagccat 746701 taagctcgat cttagctagg tattacgatc ttctgtatat tattgtgaga aatatagaag 746761 attcagttag ttagcatttc gattttaagc tgagcctgca atagcaaagc atctgttttg 746821 attattcttt ttctgataca taagctaatt ttgtcgcttt tcttttttgt cttttcacgc 746881 atttcgagga tgacttacta taattctttc agcttttcta tgtgttaaga ttcgaataga 746941 tgaaataact ttaacaagtt ggtcaataag aacagattta actttatgtt aaaagagtat 747001 ctcgtataga acataagaag aatgacgagt tttttaagat tatcatcaat tatgtgagaa 747061 taaaatatta taagggaaaa tgaaggctgt cacgtttctc gacagcccta gggaattcct 747121 ctccttttca tttcgcccgt aatttcgggc acagtcccgt cggcaggcac attggcttct 747181 ggtcgatcgg gcttctcatg atgcagcatt ccaagccgaa gacttcacgg aaaaatggct 747241 gggtgaacac atcttccggt gttccggcgt tgtatatttt tccgtccagc acactgatca 747301 gatagtcagc atattgagcg gcttggttta aatcatggag caccatgaca acggtgcggc 747361 catggtcgcg gttcagcttt ttcagcagtt caagcacttc aatctgatgt gagatgtcta 747421 aatacgtggt cggctcatca agcaaaagca aatcagtgcc ttgcgcaagt gccatggaaa 747481 tccaggctct ttgtctttgg ccgcctgaga gggcatcaag tgtccgatcc ttcagttcaa 747541 tcatgcccgt tgcttccagc gcccactcta ccatgtcatg atcctcttgg gtatgcttgg 747601 ataacagctt tttgtgagga tgtctgccaa aatagcataa ttcctctacc gtcaatcctt 747661 caggagcctg aggagattgt ggaagaatgg ccagtttttt tgcgacttct tttgatggct 747721 ggcggtggat gtcttttcct tctagtagca ctgtaccgct ttttggggcc atcagcctgg 747781 cgagcgattt gaggattgtt gatttaccgc agccattagc gccgatgagc gcagtgattt 747841 ttccttcttc tatctttaag tcgactccgt caataatcac tgtactgtca tatgaaagag 747901 tgagctggtc tgcagccagt tttcccatgg tatcctctcc ctactgtttc ctcgcttcga 747961 atttcaataa atataagaaa taaggcgcgc cgatcacggc tgtcagtatt ccggcaggta 748021 tttcaaccgg aggcatgatg ccgcgcccta acgtatctgc aattaataat ataatagcac 748081 caatcaatgc cgatgcaggc agtaaatatt tagctttttc tccggtaagc cgtctggcga 748141 tatgcggagc aagcaagccg ataaaaccga ttgagccgac gacggctaca cagcttcccg 748201 ccagcgccac cgcggtgaaa atcaggatga atctcagccg gtttgcgttt tctccgagac 748261 cctgtgcaag ctcatccccg agtgacataa gatccagctt cggtatgagt atgcagacga 748321 tcggaaaaag aatcaaaagc catggcgcaa gcagcttgac ttcttcccag tttcttcccc 748381 agaggcttcc tgtcagccaa atgagtgcag cattcacgtc gcctggaaac ttgaccatca 748441 tatattgcat tccggcgtgg cagaccgcgc ctaaagcaat gcctgataaa gccagtgaag 748501 agggctgaat gctctttttt cgggctatca ttaataatag tacagcaata atggcggctc 748561 cggcaaatgc ggagaacgga agcacgtata ccggcgactc aggaaagatg agaatcacag 748621 ccatcgccgc aagtccggag ccttttgaaa tgccgacaac gtccggggaa gcgagcggat 748681 ttcggatcac accctgtaaa atcgctccgg cagcggcaag tccagcacct gccaaaatcg 748741 ctaatataat gcggggaagg cgatattgct ggatgataaa ttcaaaggaa tgatccagtc 748801 ccagcagatt cgtcactacc gcatcaggtg aaatgtataa tgcaccgatt ccaatgctga 748861 tgacggacag aacgattaaa atcacggcca atatgagtat cgccagtaag gggcgttttt 748921 gttttctggt tgttttcttc atttcaggtt tcgccctttc cttgccaaat ataagaaaaa 748981 cggcgttccg ataatcgcgg tgacaatgcc gaccggtgat tcataaggaa atgcaatcca 749041 tctggccaga acatctgcgt acaccagcaa aatggcaccg aacagtgccg aaaacggaag 749101 cacgtattga taatgttctc cgatcagctt gcggacaata tgcgggacga gcagcccgac 749161 aaagccaatc ggcccggcga cggctacgga agcgccggaa agaattaaaa taatcaaact 749221 gatcagaatc ctgatgccgt tcatattttg tccaagccct tttgctgttt cgtctccgag 749281 accgagaaca gaaacagaac cggaaaatac gagggcaagc ccgatgccaa tgacagaaaa 749341 aggagcgatg gttatgacgt cctgccagtt gctgccgtcg attgcgcctg tcatccagta 749401 cagaacatcc tcacctgact catttaaaat aatgatggcc tgtgtcatag aggagaggaa 749461 caagtgcacg gccattcctg acagcgccag cttgacaggc gtcattccgc cggatgaggc 749521 aatcatatac acaatcgcgc cgcctgctgc cgcacccgca aaagcgaata taacagatga 749581 atagggcgat gccggcagaa tgacgagaga agcaacaaca aaaagcgatg cacccgcatt 749641 cacaccgaaa atttggggtg aagccagagg atttctggtc atagcctgca tcagcgcccc 749701 tgctacagct aggctggcgc cgacaaaaac gccgattaat gtgcggggaa ggcgaagagt 749761 agagatgatg agctgttcct ttgaaccgtc ccatacaaaa agatatttca atgaatctat 749821 gatgctgatg tctgaggctc ctactgaaag attcagccca agcccaaata taaaaataat 749881 cagtgcaatg ataaacatca tcagtcttga tgatgagcgc cgtttggctg aatgatacaa 749941 cagtctcact tccttactgc gtctggttgc aaaaacgaag aagcaaggat tcccctcgct 750001 tctcatttgt cctatttatt atacactttt ttaagcacat ctttggcgct tgtttcacta 750061 gacttgatgc ctctgaatct tgtccaagtg tcacggtccg catcatagac ttgtccattt 750121 ttcaccgctt tgagattttt ccagagcggg ttcgttttcc actcatctac aatggttttg 750181 ccttcgttgg ctgagatgaa caaaatatca ggatcgattt tgctcaattg ctcaaggctg 750241 acctcttgat aggcgttatc tgacttcaca gcgtgtgtaa agcctagcat tttaaagatt 750301 tctccgtcat aggatgatga tgtatgaagc tggaaggaat ccgctcttgc aacgccgaga 750361 acgatgttgc ggttttcatc tttcggaagt tcggctttta gatcgttgat gacttttttg 750421 tgctcggcaa gcttttcttt tccttcatct tctttattta atgctttagc aatggtcgta 750481 aagctgtcga tcgtttcgtc atatgtcgct tcacggcttt ttaattcaat cgtcggggcg 750541 atttttttca gctgtttata aatgttttta tggcgctcag cgtcagcgat gattaaatca 750601 ggcttcaagg aactgatgac ctcaagattg ggttcgctgc gtgtgcctac agatgtgtaa 750661 tcaatggagc tgccgacaag ctttttaatc atatcttttt tgttgtcatc tgcgatgccc 750721 accggcgtaa tgccgagatt gtgaacggca tccaagaatg aaagctcaag cacaaccacc 750781 cgcttaggtg tgccgcttac tgtcgttttt ccttcttcgt catggatcac tctggaatcc 750841 ttagactcgc ttttgccgct tccgttgtta ttctggcttg atgaacagcc ggatacaatg 750901 aggcaggcga gcaataaaac actcatgatg gcaatcaact tgttagaata ggtgcgcatg 750961 tcattcttcc ttttttcaga tttagtaatg agaatcatta tcacatgtaa cactataata 751021 gcatggctta tcatgtcaat atttttttag taaagaaagc tgcgttttta ctgctttctc 751081 atgaaagcat catcagacac aaataagtgg tatgcagcgt taccgtgtct tcgagacaaa 751141 aacgcatggg cgttggcttt agaggtttcg aacatatcag cagtgacata aggaaggaga 751201 gtgctgagat aaccggacaa tttcttttct atttcatctg ttagtgcaaa ttcaatgtcg 751261 ccgatattca tgataatcga gaaaacaaag tcgatatcga tatgaaaatg ttcctcggca 751321 aaaaccgcaa gctcgtgaat tcctggtgaa catccggcac gcttatggaa aatctgtttg 751381 actaaatcac tcacaatcca agcattgtat tgctgttctg gtgaaaagta ttgcattaga 751441 catacctcct gctcgtacgg ataaaggcag cgtttcatgg tcgtgtgctc cgtgcagcgg 751501 cttctcctta attttgattt ttctgaaaat aggtcccgtt cctatcactt taccatggac 751561 ggaaaacaaa tagctactac cattcctcct gtttttctct tcaatgttct ggaatctgtt 751621 tcaggtacag acgatcgggt atgaaagaaa tatagaaaac atgaaggagg aatatcgaca 751681 tgaaaccagt tgtaaaagag tatacaaatg acgaacagct catgaaagat gtagaggaat 751741 tgcagaaaat gggtgttgcg aaagaggatg tatacgtctt agctcacgac gatgacagaa 751801 cggaacgcct ggctgacaac acgaacgcca acacgatcgg agccaaagaa acaggtttca 751861 agcacgcggt gggaaatatc ttcaataaaa aaggagacga gctccgcaat aaaattcacg 751921 aaatcggttt ttctgaagat gaagccgctc aatttgaaaa acgcttagat gaaggaaaag 751981 tgcttctctt tgtgacagat aacgaaaaag tgaaagcttg ggcataaagc aaggaaaaaa 752041 ccaaaaggcc aatgtcggcc ttttggtttt tttgcggtct ttgcggtggg attttgcaga 752101 atgccgcaat aggatagcgg aacattttcg gttctgaatg tccctcaatt tgctattata 752161 tttttgtgat aaattggaat aaaatctcac aaaatagaaa atgggggtac atagtggatg 752221 aaaaaagtga tgttagctac ggctttgttt ttaggattga ctccagctgg cgcgaacgca 752281 gctgatttag gccaccagac gttgggatcc aatgatggct ggggcgcgta ctcgaccggc 752341 acgacaggcg gatcaaaagc atcctcctca aatgtgtata ccgtcagcaa cagaaaccag 752401 cttgtctcgg cattagggaa ggaaacgaac acaacgccaa aaatcattta tatcaaggga 752461 acgattgaca tgaacgtgga tgacaatctg aagccgcttg gcctaaatga ctataaagat 752521 ccggagtatg atttggacaa atatttgaaa gcctatgatc ctagcacatg gggcaaaaaa 752581 gagccgtcgg gaacacaaga agaagcgaga gcacgctctc agaaaaacca aaaagcacgg 752641 gtcatggtgg atatccctgc aaacacgacg atcgtcggtt cagggactaa cgctaaagtc 752701 gtgggaggaa acttccaaat caagagtgat aacgtcatta ttcgcaacat tgaattccag 752761 gatgcctatg actattttcc gcaatgggat ccgactgacg gaagctcagg gaactggaac 752821 tcacaatacg acaacatcac gataaacggc ggcacacaca tctggattga tcactgtaca 752881 tttaatgacg gttcgcgtcc ggacagcaca tcaccgaaat attatggaag aaaatatcag 752941 caccatgacg gccaaacgga tgcttccaac ggtgctaact atatcacgat gtcctacaac 753001 tattatcacg atcatgataa aagctccatt ttcggatcaa gtgacagcaa aacctccgat 753061 gacggcaaat taaaaattac gctgcatcat aaccgctata aaaatattgt ccagcgcgcg 753121 ccgagagtcc gcttcgggca agtgcacgta tacaacaact attatgaagg aagcacaagc 753181 tcttcaagtt atccttttag ctatgcatgg ggaatcggaa agtcatctaa aatctatgcc 753241 caaaacaatg tcattgacgt accgggactg tcagctgcta aaacgatcag cgtattcagc 753301 gggggaacgg ctttatatga ctccggcacg ttgctgaacg gcacacagat caacgcatcg 753361 gctgcaaacg ggctgagctc ttctgtcggc tggacgccgt ctctgcatgg atcgattgat 753421 gcttctgcta atgtgaaatc aaatgttata aatcaagcgg gtgcgggtaa attaaattaa 753481 gaaagtgaaa aacacaaagg gtgctaacct ttgtgttttt taattaatta aaatgtttat 753541 taacttagtt aaggagtaga atggaaaagg ggatcggaaa acaagtatat aggaggagac 753601 ctatttatgg cttcagaaaa agacgcagga aaacagtcag cagtaaagct tgttccattg 753661 cttattactg tcgctgtggg actaatcatc tggtttattc ccgctccgtc cggacttgaa 753721 cctaaagctt ggcatttgtt tgcgattttt gtcgcaacaa ttatcggctt tatctccaag 753781 cccttgccaa tgggtgcaat tgcaattttt gcattggcgg ttactgcact aactggaaca 753841 ctatcaattg aggatacatt aagcggattc gggaataaga ccatttggct tatcgttatc 753901 gcattcttta tttcccgggg atttatcaaa accggtctcg gtgcgagaat ttcgtatgta 753961 ttcgttcaga aattcggaaa aaaaaccctt ggactttctt attcactgct attcagtgat 754021 ttaatacttt cacctgctat tccaagtaat acggcgcgtg caggaggcat tatatttcct 754081 attatcagat cattatccga aacattcgga tcaagcccgg caaatggaac agagagaaaa 754141 atcggtgcat tcttattaaa aaccggtttt caggggaatc tgatcacatc tgctatgttc 754201 ctgacagcga tggcggcgaa cccgctgatt gccaagctgg cccatgatgt cgcaggggtg 754261 gacttaacat ggacaagctg ggcaattgcc gcgattgtac cgggacttgt aagcttaatc 754321 atcacgccgc ttgtgattta caaactgtat ccgccggaaa tcaaagaaac accggatgcg 754381 gcgaaaatcg caacagaaaa actgaaagaa atgggaccgt tcaaaaaatc ggagctttcc 754441 atggttatcg tgtttctttt ggtgcttgtg ctgtggattt ttggcggcag cttcaacatc 754501 gacgctacca caaccgcatt gatcggtttg gccgttctct tattatcaca agttctgact 754561 tgggatgata tcaagaaaga acagggcgct tgggatacgc tcacttggtt tgcggcgctt 754621 gtcatgctcg ccaacttctt gaatgaatta ggcatggtgt cttggttcag taatgccatg 754681 aaatcatccg tatcagggtt ctcttggatt gtggcattca tcattttaat tgttgtgtat 754741 tattactctc actatttctt tgcaagtgcg acagcccaca tcagtgcgat gtattcagca 754801 tttttggctg tcgtcgtggc agcgggcgca ccgccgcttt tagcagcgct gagcctcgcg 754861 ttcatcagca acctgttcgg gtcaacgact cactacggtt ctggagcggc tccggtcttc 754921 ttcggagcag gctacatccc gcaaggcaaa tggtggtcca tcggatttat cctgtcgatt 754981 gttcatatca tcgtatggct tgtgatcggc ggattatggt ggaaagtact aggaatatgg 755041 tagaaagaaa aaggcagacg cggtctgcct ttttttattt tcactccttc gtaagaaaat 755101 ggattttgaa aaatgagaaa attccctgtg aaaaatggta tgatctaggt agaaaggacg 755161 gctggtgctg tggtgaaaaa gcggttccat ttttccctgc aaacaaaaat aatggggctg 755221 attgcggctc tgctggtctt tgtcattggt gtgctgacca ttacgttagc cgttcagcat 755281 acacagggag aacggagaca ggcagagcag ctggcggttc aaacggcgag aaccatttcc 755341 tatatgccgc cggttaaaga gctcattgag agaaaagacg gacatgcggc tcagacgcaa 755401 gaggtcattg aacaaatgaa agaacagact ggtgcgtttg ccatttatgt tttgaacgaa 755461 aaaggagaca ttcgcagcgc ctctggaaaa agcggattaa agaaactgga gcgcagcaga 755521 gaaattttgt ttggcggttc gcatgtttct gaaacaaaag cggatggacg aagagtgatc 755581 agagggagcg cgccgattat aaaagaacag aagggataca gccaagtgat cggcagcgtg 755641 tctgttgatt ttctgcaaac ggagacagag caaagcatca aaaagcattt gagaaatttg 755701 agtgtgattg ctgtgcttgt actgctgctc ggatttattg gcgccgccgt gctggcgaaa 755761 agcatcagaa aggatacgct cgggcttgaa ccgcatgaga tcgcggctct atatcgtgag 755821 aggaacgcaa tgcttttcgc gattcgagaa gggattattg ccaccaatcg tgaaggcgtc 755881 gtcaccatga tgaacgtatc ggcggccgag atgctgaagc tgcccgagcc tgtgatccat 755941 cttcctatag atgacgtcat gccgggagca gggctgatgt ctgtgcttga aaaaggagaa 756001 atgctgccga accaggaagt aagcgtcaac gatcaagtgt ttattatcaa tacgaaagtg 756061 atgaatcaag gcgggcaggc gtatgggatt gtcgtcagct tcagggagaa aacagagctg 756121 aagaagctga tcgacacatt gacagaggtt cgcaaatatt cagaggatct cagggcgcag 756181 actcatgaat tttcaaataa gctttatgcg attttagggc tgcttgagct tggggagtat 756241 gatgaagcca ttgatctgat taaagaggaa tatgcgatac aaaatgaaca gcatgatctt 756301 ttattccata acatccattc gcagcaggtg caggccattt tgttagggaa aataagcaag 756361 gcatcggaaa agaaggtcaa gctggtgatt gatgagaaca gctcactcgc gcctcttcct 756421 gcgcatatcg gcttgtccca tcttattacg attattggca atttaattga taacgctttc 756481 gaagctgtag cggagcaaag cgtgaaggaa gttttgtttt ttatcacgga tatgggccat 756541 gacattgtca ttgaagtatc agacacaggg cccggtgtgc cgccagagaa aatagaagct 756601 gtgtttgaga gaggctattc ttcaaagggg atgaggagag gctacggtct ggccaatgtg 756661 aaagactcag tgcgtgaact gggcggctgg atcgaactgg cgaatcaaaa aactggcggg 756721 gcggtattca ctgtatttat accgaaggag aaacaaaggg ggaatccatt tgattcacat 756781 cgcgattgcg gaggatgatt ttcgagttgc gcaaatccat gagagattga ttaaacagct 756841 tgatggattc aagattatcg gcaaggcggc taacgcaaaa gagacattgg cgcttttgaa 756901 ggaacacaag gctgatttgc ttctgctgga tatttatatg ccggacgagc ttgggaccgc 756961 gttgattcct gatatacgaa gccgatttcc tgaagtggac attatgatta tcacagcggc 757021 aacagaaacc cgtcatttgc aggaagcgct aagggcggga attgcccact atttgatcaa 757081 acccgtaaca gctgacaagt tcaggcaggt gctgcttcag tataaagaaa aaaggaagct 757141 gctcatgtct cagccggagg tcagccaatc catgatcgac catatttttg ggaacggtgt 757201 gaagacagct ttgccggcag aggatttgcc gactggcatt aattcgatta cactgcgaaa 757261 aattaaggaa gcgcttcaga ctgcgtcaga aggattgaca gcggaggaac ttggggaaaa 757321 aatgggggcg tcacgaacaa ctgcccgccg ttatgccgag taccttgtgt caaaggaaga 757381 agcaagagcc gagcttgaat acgggattat cggcaggccg gagagaaaat attatttggc 757441 ggcggattag atatgaaaaa atctataatc ctattgaata ttctattgat ctttatgcag 757501 ggtgatatca ggcaggcggc tgcgccgcgc ctgccggacg ggccgataga aattgtcgtc 757561 cctgccgaac cttctggcgg ctgggatgtc acagcgcagg cgatccaatc agttttgagg 757621 cagaagcaga tcgtgaagga tgatgttcat atcgtctata aatccggcgg cgggggagag 757681 aaaggctgga aatatgtcaa caaaagcagc aaacaaacca tcagcatgac gtccagccta 757741 atattgagca atgatcttct cgggcaaagc aaattaaaaa tgtccgattt tacgccgctc 757801 gccattctct ccaaggaatg gcagacggtt gcattgccaa aaggatcagc gttaacaaat 757861 ggcaaggatg tgctgaatga gatcaacatg catcccggca aggtgagaat cggctttgcc 757921 ccggggtttg gcaatgatga tcagctctcg ttcgtcagag cggcagatat gtacggcatt 757981 gacccgtttg acattcaatt ctcacagtat gacagcagcg aacagctcat tcaggcgctg 758041 atcagacatg agatagaagc ggcttccatg acactttctg aagcgaaacc atatgaacga 758101 aacggcgata tcacgttagc cgctgtaacg tctgataaaa gacttcccgg ttttccaaat 758161 gtaccgacgt ggaaggagca gggaatcccg tttgtttttt ctcattggag agggattttg 758221 ggcccgaaaa atatgtctga ggaagagatt tcttactggg atcaagcgct aaagaaggtc 758281 acctcctcac ctgaatggaa gcggaaaata aacgaacagg actgggaaag cttttattta 758341 aacagcaggg aaacgaaacg gtttttagaa gagcaatctg ctttttatca aagcatcatg 758401 acaggaaatt aaaatcccga catcccggga tttttttcat gccgaaaatt gatcaaaaag 758461 aacaaaacgg ttttaaaaaa ttaaaaatac aaaaaaacca aattatttac ttgcggttgg 758521 ttttcccata cgatggcaaa aaggcaagac aaaaagggga gtaagggaga aaaaaatgta 758581 agcggattca tttaaggggg aatggatgtg ttagcaatct taggctttct catgatgctt 758641 gtgtttatgg cattgatcat gacaaaacgg ctttctgttt taacagcatt agttttgacg 758701 ccgattgtgt ttgcgcttat cgccggattt ggatttactg aagttgggga catgatgatt 758761 tcggggattc agcaagtcgc gccgactgcg gtcatgatta tgtttgcgat cttatatttt 758821 ggaattatga ttgatacagg cctgtttgat ccaatggttg gcaaaatttt aagcatggtc 758881 aaaggagacc ctttaaaaat tgttgtcggg acagcggttc ttacaatgct cgtcgccttg 758941 gacggagatg gctcgacaac gtacatgatt acgacaagcg ccatgcttcc gctctatttg 759001 ctgctaggca tccggccaat tatcttggca ggaatcgcgg gagtcggcat gggaatcatg 759061 aacacgattc catggggagg tgcgacgccg agggcggcga gtgcgctggg ggttgatcca 759121 gctgagctta cagggccgat gattcctgtc attgcaagcg ggatgctttg tatggtggca 759181 gttgcgtatg tgcttggaaa agcggaacga aagcgccttg gtgtgattga actgaaacag 759241 ccagccaatg ccaatgaacc ggctgctgcg gttgaagatg agtggaagcg gccgaagctt 759301 tggtggttca atttattgtt aacgctttct ttaataggat gtttagtatc gggtaaagtc 759361 agtttaaccg tactgtttgt cattgcgttt tgtattgcgc tgattgtgaa ttatcccaat 759421 ctcgagcatc agagacagcg catcgcggcg cattccagca acgtgctggc tatcggttca 759481 atgatttttg ctgcgggggt gttcacgggg attttgacag gcacgaaaat ggttgatgaa 759541 atggcgatct cgctcgtgtc catgataccg gaacaaatgg gcggattgat cccggcgatt 759601 gttgccttaa caagcggcat tttcacattt ttgatgccga atgacgcgta tttctacggg 759661 gtgctgccga ttttatcaga aacagctgtc gcatacggtg tggataaagt ggaaattgcc 759721 agagcctcta ttatcggcca gccgattcat atgctgagtc cgcttgtgcc atccactcat 759781 ttgcttgtcg gactcgtcgg agtttctatt gatgaccatc aaaaattcgc attgaaatgg 759841 gcggttctcg cagtgatcgt catgacggct atcgctctat tgatcggtgc gatctctatt 759901 tccgtatgat aattcaggcg taatgacaca cactaacggc atacaacatt ccggaggtgt 759961 cattatgagt gatccttata tgccgctgac ttcagtcaga agcggagcgg ggttcgaagc 760021 ggcaaaaggg gtgcacggcc tgactgtgca aattgcgaat gtctatttta ttcagctgcc 760081 ttctgaacct cactcatttg ttttaattga tgccggcatg ccccaatcag ccggcgtgat 760141 tgtcaatgaa gccaaacaaa gattcggtga agggtttcag ctgaaggcga ttatcctcac 760201 acacgggcac tttgaccata ttggggcaat cgaagagatc cttgagcatt gggatgtgcc 760261 tgtttatatc cattctcggg aaatgcctta tgtaacaggt aaagaggatt atcctccggc 760321 tcgtcctgac agcaagagcg ggctggtcgc taagctgtcg ccgctgtttc cgcggcactc 760381 tatcgatatt tcctcacatg tccaggcact gccggaagac ggttcagttc cttttcttga 760441 cgagtggatg tggatcgcga caccaggaca cacgccgggc catatttcgt tattccgcga 760501 tgacggccgc gtgcttgtgg caggtgatgc tgttattaca gtggaacagg agaaaatggc 760561 tgacgtcttg atacaaaaac aggagcttca cgggccgccg gcttatttca cgcctgacac 760621 agagacggcc gctgagtcca ttctaaagct ggccggtctt gaaccggaag cgttattgac 760681 cgggcacggc ataccgatga ccggcaaaaa ctttcgaagt gacttaactg aattggcaaa 760741 tcggttatcg tctatttgac acccgcacca cgcgggtgtt ttttattgtt ttccaggaag 760801 ttgcagaaaa atcatttgtc ttgccgctta aaaacgatac aatgaaaagc atgaagtgat 760861 gtgaagggga gagtttgttg gaagaaaaag aaatactctg gaacgaagcg aaagcgttta 760921 ttgccgcatg ctatcaggaa ttgggaaagg aggaggaagt gaaagaccgt ctcgcggaca 760981 ttaaaagtga aattgacctg accggaagct atgtacatac gaaggaagag ctggagcacg 761041 gagcgaaaat ggcttggaga aacagcaacc gctgcatcgg cagattgttc tggaattcgc 761101 tgaatgttat cgacagacga gacgtccgga cgaaggagga agtgcgtgat gccctctttc 761161 accatattga aaccgccacc aataacggga aaatcagacc gaccattacg attttccctc 761221 cggaagagaa gggtgaaaag caagtcgaga tctggaatca tcagctgatc cggtacgctg 761281 gatatgagtc agacggagaa agaatcggcg acccggcttc ctgttccctg acagcagcct 761341 gcgaagagct cggctggcgc ggagagcgaa cggattttga cctgctgccg ctcatttttc 761401 gcatgaaagg ggacgagcag cctgtctggt atgagctgcc gcgttcactt gtgattgagg 761461 ttccaatcac acatccggac atcgaggcgt tttctgattt ggagctgaag tggtacggcg 761521 tgcctattat ttctgatatg aagcttgagg tcgggggcat tcattataat gccgcgccat 761581 ttaacggctg gtatatgggc acggagatcg gagcgagaaa cctcgcagat gaaaagcggt 761641 acgacaagct caaaaaagta gcgtccgtga tcggcatcgc cgctgattac aatacggatt 761701 tatggaagga tcaagcgcta gttgaattga ataaagctgt gctgcactcg tataaaaagc 761761 agggtgtcag catcgttgac catcatacag cggcaagcca gtttaaacgg tttgaagaac 761821 aggaggaaga agcgggcaga aagctgacgg gggactggac gtggctgatt ccgccaattt 761881 cacccgctgc cactcatatc ttccaccgct cctatgataa ctcaatcgtt aagccgaact 761941 atttttatca agataagcct tatgagtaaa caatagaaaa tcgatgatgg ccttcaaggc 762001 tgcgggattc agtcacagag atgtcggtaa cctttgagaa agggcttccg ttctttacag 762061 cctcaacaaa cgattgcagg gcgttttccg gaccctctgc caaaatctcg acacgcccgt 762121 catcacggtt tttgacccag ccggccagtt ttcgcttatc agcttccatt tgaacaaaat 762181 agcgaaagcc cacaccttga acccggccgt ctacaatgat tcggtattga agcatgtaaa 762241 aaccaccttt tctttttatg ataatcaatc attttacaac ctgtaaaggg gatgtgtttg 762301 tatgaaacaa gagcgctatt cagttctttc tcttaatctg ggaaaaccgc agacgcttga 762361 atatgacgga aagaaaatcg aaaccggcat catgaagcgg ccggctaaat cagccgtcat 762421 gctgtatcgg gagaattttg aaggagacgg acaggcggac ctcgtcaacc acggcggacc 762481 tgataaggct gtctgtgtct acccggcgga gcattatccg ttttgggaag agttcctctc 762541 aagaccgctg tcaaatgccg catttggaga aaatctgacg gtcgcgggcc tgactgagga 762601 gaatgtttgc atcggggatg tgttcagact tgatgaagct gttgttcagg tcagccagcc 762661 gcgccagccg tgtgtaaagc tggcgaaaaa gtttggtgta aaagaaatgg tgctgaaggt 762721 ccagcaaacc ggctatacag ggttttattt tcgcgtgctg gaggagggca gggtgtctcc 762781 cggcgcgaac cttgaattgc tgtccagagg agagaaaggc atatccgtcc agttcgcgaa 762841 ccgcatcaac taccatgatg caaaaaatct caccgccatt gaacggattt taagtgaggc 762901 tgcactatcg gaaagctgga gagcgtcctt tatgaaaaaa aaggacaggc tgctgccggt 762961 tgaatagaaa aaagccgcgc atatcaacgt gcgcggcttt gccatattta agattgtttt 763021 ttctttgatt caagcaggtt ggcaagaaaa taggttttat agctttgaag ctttcttcct 763081 tcatggtgcg tgatcccctg cttttttagt tctgccacat accagccttt actgccgtaa 763141 tgcatgtcag aaaactcctt tccctatctg atttcgaaac gattggcatt gtaacatcta 763201 taaaaagatg ctgaaaagag atgcggggaa aactgagcct ttcgcactag atgtacgaat 763261 gttcttctga atgtatatgc ggagcaaaag ccgaatatga tttaatggcc ggttagtttg 763321 atcatgacaa cgccaaatgt cataatggcg aaaacaatgc cgatatatgt gagcatcccg 763381 ttttttttct taacgccgta aacggtcata atgatgcctt caatgaaaaa aatgatgccg 763441 aaaataataa accacatgca gataaaggct cctttcacag acataatagt agtgtagcat 763501 atctgaaaga gccgggctgt gacaatatca agaaagccgg gcgcatatcg cccggctcat 763561 gttttattgt ttatcaacca atttgaccag aagctgtgcc aaatgttctt tctcatcttc 763621 gtctgcaacg ctccaaagct cttgcagcag catttcttca ccgttttgcg gctcttcatg 763681 ctttgcgagg tagtctccca ggatcgcagc gctttttaca agcttgccgt catccaatcc 763741 cagctttttg cctcggttga cttgtttttt caggtagcct ttaaattcct caaagtcttt 763801 taaaatgtct tcttttattg tgccatgcat cgcgttcatt tcgttttcaa tttggatttt 763861 ttcttgatct ctgttcattg caagacctcc tcgtacagaa taatgatgct ttacctgcaa 763921 ttggaggagg ttaaacctgc cggaagcccg gaatgtgttt tacagtttcg tcaggataat 763981 cggttcatct tttgtgatga cgatcgtgtg ttcaacttgg gcaaccatgc ttttatccgg 764041 cgtcttgaac gtccagccgt ctccagcttc aacaatcgtt tctgctttcg ttgaaataaa 764101 cggttcaagc gcgatgactg tgccattttt gaacagcgca ttatcaaacg gatcataata 764161 gttcatgatg tggttcggcg cttcatgcag gcttcggccg attccgtggc cggtcagggt 764221 tttgatgacg gtaaagcctt gagagcgtgc ttcatgataa acggctcttc cgatctggtt 764281 ttggcgcttg cccgcttttg cctgctgaag ccccttttga aaagcgtttt ccgcgcattg 764341 gcaaagctta tgaaggcgtt cttctccttc accgagcaca aatgagatgc ctgtgtcgga 764401 atagaagccg ccaaattcag cggagatgtc gatgttgaca aggtcccctg cttttaaaat 764461 tttggatgtg cttggtatgc cgtgagccac ttcatcattt acgctgatac atgtcacacc 764521 tggaaaatcg tattccttct caggagctga aacggcgccg tgctcatcaa gcacagcttt 764581 tccgataagg tcaaggtctt ttgtgctcat gccgggctct gccttccgct tcatttcttc 764641 acgcgcaagc gcgacgattc ttccgatttt tttcaggcct tctaattctt gatcgtttgt 764701 tacaatcatc tgtcattccc gctttctttt taaataatct agattaagct taccacaact 764761 gtcttaaaaa taggaaacac acggacctgg gaaaaaagaa atacccccgg gaaaattggt 764821 atagatcact agatatctta tatggtatat ttgaaaaaaa agggtatgag ggggatgggt 764881 atgctttcat ttttacaaaa actcgggaag tcatttatgc tcccgattgc ggttctgcct 764941 gcggttggaa ttatccttgc gcttggcaga gaggatgtat ttaatatccc gtttgtctat 765001 caggcgggga cggcggtttt tgatcatctg ccgcttattt ttgcgatcgg tattgccatc 765061 ggcatttcaa aagacagcaa tggggcagcg ggtttatcag gggcgatatc gtatctgatg 765121 cttgacgcgg caacaaagac aattgataaa acaaataaca tggcggtgtt tgggggaatt 765181 attgccggtt taattgccgg ttacacctat aaccgcttca aggataccaa gctgcctgaa 765241 tatctcgggt tcttcagtgg cagacggctt gtgccgattt taacagccat tattacgatc 765301 attttagcgg gcatattcgg agtggtctgg ccgccgattc aatcgtgtat caactcgttt 765361 ggagagtgga tgctcgggct cggcggcatc ggggcaggca tattcggcct attcaacagg 765421 ctgttaattc cgcttggcct tcaccatgtg ctgaacaata ttttctggtt ccaattcgga 765481 gaatataacg gagtgacagg ggatttggcg cgctttttcg cgaaagatcc gactgcgggc 765541 acatatatga ccggattttt cccaatcatg atgttcggtc ttccggcggc gtgtctggct 765601 atggttgtga ctgcgaagcc gtctaaacgg aaagcgacgg ctggaatgat gattggattt 765661 gctttaacgg cgtttatcac agggattacg gagccgattg agtttgcatt tatgttttta 765721 tctccgcttt tatacgctgt tcacgcggtc ttaaccgggt tatctttatt tatcgtcaac 765781 tggctcggca tccgctcagg cttctctttt tcagccggag ctatcgatta tgtgctcagc 765841 tatggaatcg cggaaaaacc gctgcttctg cttttggtag gtatatgcta tgcggcagta 765901 tactttatcg tgttttatgt actgattaag gctttgaatt taaaaacgcc tggacgggaa 765961 gacgatgatg tggatgaagt gctggatgaa aatactgttc aggatgtaaa tgaaaacatc 766021 atgctgaaag ggctcggcgg aaaagaaaac cttcaaacca ttgatcattg cgccacaagg 766081 ctgcgactga ctgtgaagga taccgctttg gtggatgaag cactgctaaa gaaagcaggc 766141 gcaaaagggg ttgtcaaatc gggcgggcaa tcggttcaag tcattattgg cccgaatgtg 766201 gaatttgcag ctgaggaatt gagggctgct gtcaaataaa aaagcggaga gggcaacctc 766261 tccgcttttt cttatttatc ttcgttatcc tttgacgttt cggaagaatc ttcgtcatgt 766321 tttgtgtaat cataatcaga aggattcacc ttcttaaaac ctttcggctc gtagaaccgc 766381 agcaggtctc cgtttatgat tttatcggac atttcaagtt ccttcttgac gagtgagtct 766441 tctgacttgt cgacttcgga ttcatcgagt tcttttccgg ttttcgtgtc gtaatactta 766501 ccggatattt tcgtgtactt cggtgaaata aagtctccgt ttcggaacgg aatcacttca 766561 cggtgttctt tcgataaaat atcagaaccg gacatcagat agtccttcgt atccactccg 766621 agcagatgca gaatggtagg agccacatca acgtctccgg catatttatg aactttctcg 766681 cccttcacgc cggcagcgtg gataaagagc ggcacccgtt gaagctgggc gttgtcgtaa 766741 tcagtgattt catccttgcc aagcactttc gccatcgctt tattgtggtt ttcagagatg 766801 ccgtagtggt ctccgtacat cacaataatc gatttatcat ataacccgtc ttttttcaga 766861 tcattgaaga attgttcaat ggactgatca aggtaatggg ctgactggaa atagttatcg 766921 acgacagagt caccaaagtc tccagccggg aagtctgtat ccccctcatc cattccgaat 766981 gggaagtggt tggaaagggt aatgaacttc gtatagaacg gctgcggcag gctttccagc 767041 agcggcattg attctttgaa gaacggtttg tctttcatgc cgtagttttt cgtgttttct 767101 tcgttcatgt catagtaagc agaatcaaag aatttatcaa tgccttccgc cttgtacatt 767161 tcgttacggt tccagaacgt ctgcgtgttc ccgtggaaag tagcagatgt gtaattctta 767221 gacttcagaa tcgccggaac ggattgcagc gtgttttgcg ctttgtttac gaaaactgaa 767281 ccttgagcca gcgggtacag agagttttcc atcataaatt cagcatcaga tgttttacct 767341 tgtcccgttt ggtggaaaaa gttatcaaag tagaacgttt cgttatcatg tgccagttta 767401 tttaagaatg gtgtcacttc tttgccgtca attttatagt cgatgataaa tgactgcaaa 767461 gattcaagtg aaacgtaaat gacgtttttt ccttccgctt tgccgaaata cacgttattc 767521 ggcacatcgt aattggcttt catgtagttt tctacttccg ttacgtcgct ggaatcggca 767581 agcgcgcgct ggctgttgga cttgatattc tgtacagcgt cataaatcgt gaaattgtat 767641 gttcccaagt atttcacaag atagttccgg tcgaatgatc ttgtcagcaa ttcaggacgg 767701 tctgattccg caactgccag gttgatcaag aacacaagaa ttgaagacgc aaaaataatt 767761 cggaacgatt ttttgcttga cgtttcggca ggcttgttta ctttgatcgc caagatgatc 767821 aggatgatcg tatcgataaa gtaaaaggcg tcagtcggtc tcatcagcga aaatgcgctg 767881 tcaccgagtt ggccgccgtt tgttttagcc tgcataatga ccggaattgt aataaaatca 767941 ttgaaaaatc tgtagtacac aatgttggcg tacagtaaaa aagacattaa aaaatgaatc 768001 actataatgg ctgtctgctg taattttttc ttgaacaaga gtccaaagcc aagaaagaac 768061 aagcttgagc taagaggatt cacaaaaagc aatatttttt gtatcgtgtt gtctattcct 768121 aagttgaaat tcaggacata accgacatac gttttgatcc ataacaggac gaccgcaatt 768181 aagaagaagg ccagtcctct ttcttttata aatgttttca ttgttacact ccttttttcc 768241 gatccagttc gagcgaaacg atagaaaaaa cgaacgtatc caatataaca cgaatcagca 768301 gattagaaaa gtgaaaatcg tatgagggag aaagtggcga aaaacgccgt cgaatcaacg 768361 tttcgctttg atattaccaa atgtaaaaca aggtatcttt ctagaaataa aggaataaaa 768421 tggtacattg agaattgtat gataaaatat aaggtataga taaaaagagg tgaaatgatg 768481 gatttttccc atattgtgtc tgaagataaa attaagcgcg ccatcaaaga cggggacttt 768541 caaaacctcc cgggaatggg gaagccgctg ccgaaggatg acgcggcaca cttgccggaa 768601 tcgctgcgca tgggctatcg tattttgaaa aacgcgggaa tggcagagga cgagggcgcg 768661 ctcaaaaaag agcttatgac catcgaccat ttaatcgaaa agtgctatga cgaaaaagaa 768721 cgcgagcaat taatcagaaa aaaatctgaa aagcaattgc tgcttgataa gcttgtcgac 768781 aaaaaaggca tgttttcaaa gccagcatcc gctttttata agaataaagt atatgaccgg 768841 cttggacgaa acagaccttc ttccagctga tttgtcttgt ctgcaggatg gcgattgata 768901 aaagccatcc tttttatgtt ccaagttcta tgtcaaaagg tttatgtttt tccatctatg 768961 ggaaatgatt cataaacgaa aaaagggtga tgggatggaa cgactattag tatggataga 769021 gcatatatct gattggctgt ggggtccgcc gctaatcatc ctgctgacgg ggacgggctt 769081 gtatttcact attttgctga aaggttttca atttcgctat cctttataca ttttcaaaca 769141 gacaatcggc agtgtaggaa aaaagccgaa gggagaaggc acagtcacac cgcttcaggc 769201 attgacctca gccctcagtt caacgatcgg tgcagcgaac attgtcggtg tgcccgccgc 769261 tattatgttt gggggaccag gagcggtttt ttggatgtgg cttattgcct tatttgccat 769321 ggcgattaag ttttctgaaa gtgttcttgc tgttcattac agagaaaaaa atgagcaggg 769381 tgaatacgtc gggggaccga tgtattacat aacaaaaggg ctgcgcatga aatggctcgg 769441 cgtattcttc tctgttgcgc tgattgtgga gctgattccc agcattatgg ttcagggaaa 769501 ttcggtttca gtctcgcttg ccgagacgtt ttctttcaat aaaatatacg caggaatcgg 769561 aattgcattt ttgattgggt tagtggtgat aggaggggta aagcggatcg gaaaagtaac 769621 agagtttgtc gtgcctctta tggcaggggc atacgcaggt gccggtctcc tgattgttct 769681 catgaatcta tcatcagtgc cggcgttttt ctctctcgtt ttttcaaatg cgtttacctc 769741 ttcttcagca gttggagggt tcgcaggtgc tgcgttggcg gaaaccgttc gctggggatt 769801 tgcccgcggg ctgtattcta atgaagccgg gatgggaaca gccccgattg cacatgcggc 769861 agcaatgact gatcatcctg tgcggcaagg gttttggtct gtgatcggca ttgtcattga 769921 caccttaatc atctgtacga ctaccgcttt tatcgtcctt gcatccggtg tatggacagg 769981 gaagaacgcc tcaaatgacc cggcagcact gacaacggcc gcatttcagc actatttcgg 770041 ttctggagga ggatacttcg tttcggtttc cctggtcttc tttgtcgtat caaccattat 770101 ggttgtcatt ttttacggcg taaagcaagc tgaatttctg ttcgggcggc tggcaggaca 770161 tgtgattaaa ttcgtttatt tagcggctat tatcataggt gccgcaggcg gagcaaaagc 770221 catttggggc gtattggact tagcattggt ttttattgtt gtcccgaatg tgattgcgct 770281 cttgttattg agcagaaagg taaaagcgct gtacaccgaa ttctttacat ctgaacagta 770341 ctacctgaaa gatataagaa aaacgaaaca aaagcctgtt tatccaacaa aagaagctaa 770401 aaattcctag tgttttgctt ttgcgccgaa caatgctttg ctttttatga tcaaataaat 770461 gagtaaaggc agcaaaagag aaatcactac attaatgatt ggtttgattc tgttaaagtc 770521 gattagctga tttgtattta aaaaaaacca aaagccgcat acgactgaga acatgccggt 770581 tggtgtatac atggctttcg ggtcgatttt tgagtgtaaa aacgaaaggc cgtataccac 770641 gatatatagg gaacctgcta tcttcaccat aatgaccgga atccaaaaag ccgcgatgat 770701 caggtctgag cgatccagaa aatccgtaat gcggatctgc ctgatgacca tataagcagg 770761 atcaaagaaa gtagatgtca ggttgggacc aaagacagaa attgaagaaa ataacatcac 770821 ggccagcaat aaagcgccca gcagtatcgc gaaaatggtg tattttagcg ggacgctccg 770881 gtttgagaag agaagcggaa ggataatcaa ttcccccatt gtcccaaacg cgtaatagcc 770941 tgattgaagg tatgggatta gaccttcaaa aacaggtgtc aagttttgaa gctcaatttg 771001 tgtggccagc gtaaatggaa ggaacaagac caggatgccg aatggaaata ggaatatctg 771061 cgccattctg gtcaatgttt cttttccctc tctggcaata cagatcgcca caaagataat 771121 aacaccgcca agaacagcca ttggtgttct cgggagaaat aaaatgttaa tcaaattgat 771181 gaaaaaacgt atatcatgag cattgattaa caggaaatac aaagaaaaca gtaaaatgat 771241 aatccggcct gcgattggtg aggaatcgct cagcagctca tagatatttt tatcctgatg 771301 ctttttcatc agcctatgca tgagccagag tgccggaatc acgatgacaa cgccgaggat 771361 gtagctgtgc caggcatttt gttttgctga ttcgatcatg agaatcggag catgctttaa 771421 tccgactgct aacgtataca gagctccgaa aaataatcct tggtatgcag aggtcttgtc 771481 cataaagcac atcctttctg tcatgttcaa aacggaatat atttaaacag gtgccccagc 771541 cgcggaagca ggggattcac tctcatataa atccatagaa aagcacttcc tgcaattagc 771601 aggctgaagg cccattttgt tagattgtta gcggaacgaa aattcttcca ttcatatgcg 771661 tatatggcaa tgcacacaat caatgtctgt acgatatagc tgatcatgct gacgcacctc 771721 cattaatggc tgatcgtttt gtataggaca ccgccctgct caatcgtcac aattgggacg 771781 acgtgaacct ccatatcctt atatacctct tcccattcct ttttcagcag attcttcgtg 771841 gttgccgtgc ttctgatggt cctgtcttga aagccggccg ggtccgcctt tagcttttgc 771901 aaacgatgaa cggtgctgat cacgtccttc tttatggttc tgtttaatgc tttttgaatg 771961 atgtaatact ggtcattttc tctcgtctca taggttgatt ggttttccat aataattcct 772021 ttggctctga tctcgattgt cattgacagc tttccgtttt tttcagcggc atgaaaggat 772081 gcattggact tttgaagctg aatggatgct tgccccattt gattcggcag gtctactatg 772141 aattctggct ggcgggcttg attcagcaac atcagggctg ctgtcatgtg ttcatctttg 772201 aaaatatcca tcaatctgtc ctttttaaag atcgcaagcc cgtcaatttt caaattagat 772261 ttgcctttcc ctccaggttt tgttttagat gcagagatga ccggtgcata cggatcactg 772321 cctatttcta ctagatcaga catgaatctg cttaagaaaa cggggcggct cgttgcgata 772381 atggccagct cccgaatcat ttccgccgga aactgttcaa gctgaacatc ggtatttaaa 772441 atgtcccgcg cttctccccg gctgactaaa atgagcgccg ttaatctgtt ctgcggattt 772501 cgcgttaaaa tatcaaagac tggggcaacg ccgtctctcg ccatatcctc tccaataatg 772561 actgtacgtc tgtgggacgt attgattgtc cgtgacaagg aggtttgcag cttgttgttc 772621 gcttctctga tcgtagtgcc ggaagctgaa tcaacatacc atgtttttga accggcagtt 772681 ccgccgccgc cccctgtttg tccgcctaat tggccgacca agggaatctg catggccact 772741 cgatactgat cttttttctt atcaatggct gagctgacaa caaatgcaat gtcattgatt 772801 tctgtccggt cccagcaccc cgttagaagg atacaaatga gaagcggcaa aacacactta 772861 tatattgttt tcttcatctt ttgggtcctc tcttttcgct cccttctgtc cgttgccgcg 772921 cgaatacgtg cccggccttc tggtcatcgt ccaccaaggc gccctgacaa aaatatcttt 772981 tacttcatct cgtttaaacg gagaaatccc ggataaataa ggaatgccga aagattgcag 773041 cttgcataaa tgaagcacta agataatcgt gccgagcata atgccgaata tcccaaaaat 773101 actcgccaaa aacataagcg ggaaacgaag catcctgatg gagatagcta agttaaaccg 773161 cggaattgta aatgacgcga tccctgttaa cgatacgatg atcaccatgg gggcagacac 773221 aattcccgct tcaacagcgg ctgtcccaat gactagggcc ccgagaatac tgacggtctg 773281 gccgatggtt ttcggcaggc gcactcccgc ctcacggaga gcctcaaaag aaatttccat 773341 aatcaatgct tctatgatgg cggggaaagg aatcggttca cgcgcagagg ccacactgaa 773401 cattaagttt gtcggcatta agtcctggtg gtatgtaata acggcaacat aaatagccgg 773461 caaatataaa gcaacgaata aaaacatata gcgaagccag cggattaagt tagacatcaa 773521 ataacgctca tagtaatctt cactggcctg cataagctgc caaaacgtaa tcgggcctgt 773581 taagacaaag ggcgtattat ctgtgaaaat ggcaaatcgg ccttcgagaa gctgggcggc 773641 gacggtgtcc ggcctttctg tgtattgcag ctgggggaat ggcgagtacg tgtcgtcttc 773701 gataaattct tcaatatatc cgctttctaa gacagcatca atctttatct ttttgattct 773761 tttttttgct ttgtcaataa cctttggatc ggcaagcccg tcaatatagg ccaagacaac 773821 atcggttttg gttttcgtgc cgattttaaa agagatcatt ttaagctgaa acgttttgac 773881 gcgaaagcgc acaagagcgg tattgaccct gaggctttca gtgaagccct ctcttgaccc 773941 tctgatggtc gattctgtta tcggctcttc aatgcttctt ctttgtccgc cttttatatt 774001 taagatcagg ccttttgagt gcccgtcggc aaataaaacc gcgttcccct caatgatgga 774061 tgcagccact ttgctcatac tcgtttctaa tgcaacactt gaaattgata gagtattttg 774121 cagcgcctct tcatgttcat ctatttgatc cgtcaaatgc attaagaaag ggcggagggc 774181 gtgatcctga atatgttcag attttacaat tccttcgata taaacaataa atccgcacag 774241 cccgtttcca aagtcaaatt gtctaaatac gatgtctgag cagccttctg ttaataaggt 774301 cagattttcg aggttttcct tcaaattggg agagatcggt ctgtcctgat tgtcttcaag 774361 ctctttgatg agctgaagcg ctttgtcgcg tttattcata gaggctcacc ctgcttttta 774421 atgtcatatt caataagtgc ttgtgacttt tagggtaacc ttgtctgttt catatattcc 774481 agactaggat gaaagcgcta taaaaaagtg ttgactacct gtatatacag gaatacaata 774541 tgattataag ttgtatatac aagttataaa aacggatacg gaggggttgg catgggggaa 774601 ctgaacaaat cggcacgtca gattgtcgaa gcagtcggcg gtgctgaaaa tattgcagcg 774661 gcaactcatt gtgttacacg tttgcgtttt gctttaatag atgaaagcaa ggttgaccaa 774721 gagatgcttg atcaaattga tgtggtaaag ggatcattct cgacaaacgg acagtttcag 774781 gtcgtaatcg gccagggaac tgtcaataaa gtatatgctg aactggttaa ggaaacgggg 774841 attggcgagt caacaaagga tgaagtgaag aaggcctcag aaaaaaatat gaatcctttg 774901 cagcgtgctg tgaaaacgct tgcagatatt tttattccaa tattgcctgc gattgtcacg 774961 gcgggtcttt taatggggat caataacatt ttaacggcgg aaggcatttt cttcagcaca 775021 aaatcgattg tgcaggttta tccgcagtgg gcggatcttg ctaatatgat taacctgatt 775081 gcaggcacgg cctttacgtt tttgcctgcg ttaatcggat ggtctgccgt caagcggttc 775141 ggcggcaatc cgcttctcgg cattgtgctc ggggttatgc tcgtgcatcc tgatttgctg 775201 aatgcgtggg gatatggcgc ggcagaacaa agcggagaga tcccggtatg gaatctattc 775261 ggcctagagg tgcagaaagt cggctatcag ggccaggtgc tcccaatttt gcttgcttct 775321 tatatgctgg cgaagattga ggtattttta acaaaacgca cacctgaggg catacagctg 775381 ctcgttgtcg caccaattac gcttctctta acaggatttg cctcttttat cattatcggc 775441 ccgattacat ttgcgatcgg taatgtactg acttcagggc ttatctcggt gtttggttct 775501 tttgccgcac tgggcggtct gttatatggc ggtttctact cagcgctcgt gattaccggt 775561 atgcatcaca cgtttcttgc agtcgacctg cagctcatcg gttcaaagct cggcggcacc 775621 tttttatggc cgatgctggc gctttctaat atcgcacaag gttcggcggc tctggccatg 775681 atgtttatcg tgaaggatga gaaacaaaaa ggcctctccc tcacatcagg gatttctgct 775741 tatcttggca ttacagagcc tgccatcttt ggggtgaatc tgcgatacag attcccgttt 775801 atcattgcaa tggtcagctc tggcctggcc ggaatgtata tttcttctca aggtgtgctg 775861 gcaagctccg tcggtgtcgg cggcgtgccg gggattttct caatcatgag ccagtactgg 775921 ggcgcgtttg caatcgggat ggctattgta ttgatcgtgc cgtttgccgg aacatacgcg 775981 tatgcgagat tcaaacataa ataacaagtg gggagcggga cgtgttgaac gttccctttt 776041 cccgttttca atttaaatat ggtggtggaa acagatgaaa acagaacaaa cgccatggtg 776101 gaaaaaagct gtggtttatc aaatttatcc gaaaagcttt aacgatacga caggaaatgg 776161 tgttggcgat ctgaacggca ttattgaaaa gctggattac ttaaaaacgc tacaggtgga 776221 tgtgctttgg ctgacgccga tttatgattc tccccagcat gataatgggt acgatattcg 776281 tgattattac tcgatttatc ctgaatacgg aacgatggag gattttgagc ggctagtgtc 776341 cgaagcacat aaaagagacc tgaaagtcgt catggatctt gttgtcaatc atacgtcaac 776401 agagcacaaa tggtttcgcg aggcgatctc ttcaatagac agcccgtacc gtgattttta 776461 tatatggaaa aaaccgcagg aaaacggttc tgttccgacg aactgggaat cgaaattcgg 776521 cggctcggca tgggagcttg acgaagcatc gggccaatac tatttgcatc tgtttgatgt 776581 gacgcaggct gatttgaatt gggaaaatga agaggtcaga aagcatgtct atgacatgat 776641 gcatttttgg tttgaaaagg gaatagacgg ctttaggctt gatgtcatca acctgatttc 776701 taaagatcag cgctttccga atgcggagga aggcgacggc cgctcttttt acactgacgg 776761 gccgcgggtg cacgaatttc tgcatgaaat gaacgaaaag gtgttttcac attacgacag 776821 catgacggtc ggtgagatgt cttcaacaac cgtagaccac tgcatccggt atacgaatcc 776881 tgacaataaa gaacttgata tgacattcag cttccatcat ctcaaggttg actatcctaa 776941 cggcgaaaaa tgggccttgg cgccgtttga ttttttgaag ctgaaggaga tcctatctga 777001 ctggcaaacg gggatgcacg caggaggggg atggaacgct ctgttctggt gcaatcatga 777061 tcagccgcgc gtcgtatcaa gatatggaga tgatggcgca tatagggtga aatcggcgaa 777121 aatgcttgct acggccattc atatgatgca gggcacgcct tatatttatc agggcgagga 777181 gctggggatg acgaatccga agttcactga cataagctcc tatcgggatg tcgaatcgct 777241 gaacatgtat cacgccttta aggaaaaagg aatggctgat caagatatta cagccatttt 777301 acaggcgaaa tcccgtgaca attccagaac ccccgttcag tgggatgcta cggaaaatgg 777361 tggttttaca acgggcacac catggatacc ggttgcagga aattaccggg aaatcaatgc 777421 tgaagcggcg ctgagggatc agaattcggt gttttaccat tatcaaaaat tgattcagat 777481 tcgcaaaatg tatgacattg tgacagaggg tacgtatgag ataattgcaa aggatgaccc 777541 gaacattttt gcgtatctca gacacggcag caatgaaaag ctgctcgtga tcaataattt 777601 ttacgggaca gaggcggcct ttacactgcc ggactcttta gcgcctgacg aatggaaggc 777661 agaggtgctg ttgacgaacg atgaagcaag ggaagggctt cagaacatga cgcttcgccc 777721 atatgagtcc attgtttatc gtttaacgaa accgtgttaa actaagctgg gtggtccata 777781 atgaaggtga ataaattcat cacaatttat aaagacatcg cacagcaaat tgaaggcggc 777841 cgatggaaag cggaggagat tcttccgtct gaacatgagt tgaccgcaca gtacggtaca 777901 tcaagagaaa cggtccgaaa ggcgcttcat atgctcgcgc aaaacggtta tatccagaaa 777961 atcaggggaa aaggctccgt cgtgctcaat cgtgaaaaaa tgcagtttcc cgtttcgggc 778021 cttgtcagct tcaaggagct cgcgcaaacg cttggcaaag aaacgaaaac aactgtacac 778081 aaattcgggc tggagcctcc gtcagagctg atccaaaaac agctccgggc caatctggat 778141 gacgacatct gggaagtcat caggtctaga aagattgacg gggaacatgt gattttggac 778201 aaggattact ttttcagaaa gcatgtccct cacctgacga aagaaatttg tgaaaactcc 778261 atatatgaat atatagaagg agagctcggt ctttcgatca gttacgccca aaaagaaatt 778321 gtagccgagc cgtgtacgga cgaggacaga gagctgctcg atttacgcgg ctatgaccat 778381 atggtcgtgg tgagaaacta cgtctttttg gaggatacca gtttgtttca atatacggaa 778441 agcagacacc gtctcgacaa attccgattt gttgattttg cgcggcgggg gaaatgagag 778501 aggcgcctgc ctgcggcagc gcgctttttt gtttggtatc aaaattgata ctatccaaca 778561 aaaatgtgcg tacttttact ttttatcata atggctacaa tagagatgag agtaatctaa 778621 aggagaggtg ttttacatgg cagatctaaa gacacaaatt ctggatgcat acaatttcag 778681 gcatgcgact aaggaatttg acccgaataa aaaagtgtca gacagcgatt ttgaatttat 778741 tttagaaaca ggaagactgt ctccgagctc actcggcctt gagccttgga aatttgtcgt 778801 cgtccaaaat ccggaattcc gcgagaagct tcgtgaatac acatggggcg cgcaaaagca 778861 gctgccgacc gcaagccatt tcgtcctgat tcttgcgcgt acagcgaagg atatcaaata 778921 taatgcggac tacatcaaac gtcatttaaa agaagtaaaa caaatgcctc aagacgtgta 778981 cgaaggctat ttaagcaaaa cagaagaatt ccagaaaaac gatttgcatt tgcttgaaag 779041 tgacagaaca ttgtttgact gggcatcaaa acaaacctat atcgcgcttg gcaacatgat 779101 gactgccgct gcgcaaatcg gtgttgattc ctgcccgatc gaaggcttcc agtacgatca 779161 cattcaccgt attcttgaag aagaaggcct tctggaaaac ggaagcttcg atatttctgt 779221 gatggtggca ttcggctacc gagtgagaga ccctcgtccg aaaacaagat ctgctgttga 779281 agatgttgtg aagtgggttt aaaagaagaa agctgctcgc atagcgagca gctctttttt 779341 atgcctgatt cgctctattc tgttttctcc tctgatgtaa gtacattgcc gttccgagtg 779401 cgctgatcag aaatccggcc aacaggatcg agtacatgga tgtggctgtg tccggaagca 779461 ggccgccagc cggaccgtct gttcctgatc cgcccgaacc gtttccacca gagccgttag 779521 tcggttgagt gccgggaggc gtatcatttc ctccgtttcc gtcagttggc tgttttccgc 779581 ctggtttgtc ggagcctccg ccatgattgc cgtcatcacc gcctgtcggt tgatctgacg 779641 ggaatgccgg cggtttgttg tttgaaccgg aatttaagat cgtgtattcg ctgaagtggt 779701 ttgtatatcc tgtcaccata tcatcatcga ctgatccgtg acctgtcttt gtgaaagctt 779761 tcttttttct atcgacgtga taaatggcag ggttatgggc ttcttcaata tcaaacatgc 779821 gaagcgaaag ctgtacgggc tccttgaatg attttatttc ttttcctttt tgcttcactg 779881 taaagtcata tacatctgac agtgacacat ccaattctcc cgtagacttg attccgattg 779941 cagtgtctgc ggttttaagg ttcgccattg gcatcttcat gctgtaccag tagttgaaca 780001 tcgtcaatga aggatctgac tctctttctt tcaaaagttt gacctgatct tttttcactt 780061 taagattgat aggcttctct tgagatcctt catgtattcc ataatagaca aatggcgtgt 780121 tggcattttt agcataaatc gcaaatttgt cttcatcaag tgtccagctg ccgtccttct 780181 gctttgtcgg caggaatact tctttgattc gtccttcaac tttaggagag accttgtttc 780241 ctagtttttt cagctgttcg gtgaaaatct cataatcaac gtagccaagg tcttcaccat 780301 gggaggcttc tgtaaagaca gaatatccgt ctcctccggc accgacaaaa ttatttgttg 780361 ccacgcggta ggtatcatcc gtatttatag caactttgtc tccgttaggc gattcaattt 780421 tcacttctaa cacacggtgt ccaggtttgt tgtttaatgt aaaggtatat tcgattccgg 780481 ccacctgagg gaaagcgccg ccgccatttt ccacattgct taggccttgt tcaagggctt 780541 ctttaatttg ttttccggtt aaatcggcca cgtaaagcgt attgccgaac ggcatcacgt 780601 tgagcacctc gccgagtgtg atatcacctt tgtcaatgcc tgctctgatg ccgccgccat 780661 ttgttatcgc tattctggcg ccggctgctt ctttcgcttt tgccagcata ccgtccgcga 780721 tgaagtttcc gagattcgtt tctttcgtgc gcacatgctc acgctggccg tcaagcgcca 780781 catccgtgta gccgactttt tcatttttca cgtcctctaa ttcatttttg aactgatcga 780841 gctcttgttt tgcttctggg ttttcttctg tatgttcatc aattggcagc acgctcagat 780901 ttgatttatc tgtttgcaca acgccttttt catcaaacgc gacatcaacg cgccccaaga 780961 attggccgta ttcttttgcc tgcgccacga tcgtcggttc ttcgttgttc acgacctcca 781021 ttttgtctac gagggtgtga gtgtgtccgc cgatgatcaa atcaatgcct tttacttttt 781081 tggctagctc aagatcccgg ttatgtccga tgtgggttaa agcaataatt ttatttacct 781141 tttcttcttc ttgaatcgct ttgacggtgt tttgtgctgt ttcaaaggca tcattgaata 781201 cgatgctttt gcccgggctt gatgtggtgg ctgtatcttc tgttgtcagg ccgaatacgg 781261 cgactttctc cccgtcaacg tctaacagaa tgtaagggtg aatgccggcc tctttctttt 781321 cacctgccgt aaaggtttgc ggctttttga caaatgattt cagcttgggc tcatttgaca 781381 catctacgtt tgcactgaca atcggaaatt ccggcgcttc aaagtgatag cggttcgccg 781441 gatcaacggt tgcgctgttt ccgcttagaa aatcagaaag caccgtcggg cctttgtcaa 781501 attcatggtt tccgaaggtc atggcgtcat agcccatcat gttcatcatt ttcagatcgg 781561 ccaaaccgtt ccatttagta aaatacagat cgccggaaaa cacatctccc gcatcaagga 781621 gaatattgtg atttgtttcg ctgcgtactt cgttgatttt cgtcattcgt ctcgctgcat 781681 catcgagatg ggcgtgcgta tcattggtgt gcatgacggt cagatcccac agtccgtctt 781741 taggaggatc tggatttgaa tcatcatcga attgcagctt atacacacca tagccttcat 781801 tcgcagactt gcctacataa gcgacatcgt ctgctttatc ggcaaatggc ttggccaaaa 781861 gcgaggattc aaacgtcaga ttcgtgccgg aaacaggcgc gattgaccag ttgttgtctg 781921 cttttggatt gactgttttt tgttcaataa tgtaatccat cagcacctgc ctattttcaa 781981 ctgcagagcc gtggacaatt ttatcgctcg tcagatgagg gaacccgccg cctccggacg 782041 cacgatagtt attggtgact acgagaaatt cctggcttgg gctgatcggc ttgccttcat 782101 aggaaagatt gatgatacgg gatgaatccg cattgatcac ttttccgttc tcattgtatt 782161 tagccggttt tgtcacatcg acctgatatg tgacaccgtc aatcacgtca aaattatagg 782221 agcggaaatt ctcgttcagc aaggcctggt cgccgccttt agctggatca atttgattga 782281 attggcctgc tgacatctcc agccagtcct tgacctcgct gcctgtcagc ttgacgattt 782341 gaacagtatt atcgtaaaga tacaagtcac cgacattttt aatcgcaaga tctccggctg 782401 gaatgtttgt atagtaattg gctccgtttc tgccgcctgc tttaaacggc gctccagcgg 782461 ataaaatcgg caggttcttg tactcggtat ccttcatttc tttttcagcg taccactttt 782521 gcgcgtcagt cacgatctga atggaaggat catctttgac ctgtgcaaag aagctgttaa 782581 tatctgcttc ggttttgccg actggctttc ggacatactc cagtgtgttt tggtgtgttt 782641 gctgaatggt gtttgtaacg gtttcgtttc ttgatgtgac gttgccagca atagattcaa 782701 tacttccttt ggaatctgct accttccatg agccgtccgc cttttcaagc ttgaggtcaa 782761 tcacgcctaa atatttgccc cagctgcttg gcatgacgac aggaatgccg ttaattgttc 782821 ccttttccac attgaactga gcaacacccg catactcggc ggaaggaaag agtccgtgct 782881 gatggcccga gataatcgcg tcaatgcctt tcgttttggt ggcaaggtca aacacggcgt 782941 tttctgcgcc tgatgattgc gcctgctttt caatgccggt gtgggcgagg gcaataatga 783001 catctgcgcc ttccgccttc attttcggga tcgtttcatt ggcggattct acgatatcct 783061 gcacctgaac ttgcccctcg agattctttt tgtcccatgt catgatttgc ggcgggacaa 783121 agcctatgta gccgactttt actttctgct cattaccgtt ttcatcaatg agggtttttt 783181 cattaatcac atacggcgta taacggtttt cgccgctagt tgttttgacg ttggcattta 783241 caatcgggaa atcggctcct ttgattgtgc cgtcgagaaa gtcgagcccg tagttgaatt 783301 catgattgcc aagcgttccg gcgtcgtatt tcagcgcatt catgacgctg ataatcggat 783361 gggttttcgt gccggagata atgtcgtctt tttgatattt caccgcgtat tcacccagcg 783421 gattcccttg aatcaagtcg ccgttatcca caagcagggt gttagggttt tgctcgcggt 783481 gcttttggat caattgcgct gttctcgcca gaccgaaatc cgccgtttct ttgtcgctgt 783541 agtaatcgta atccatcatg ttggcatgaa tatcagtcgt agccaaaata ctcagatgca 783601 cctgaggagc cgcgctttct tctgcatgaa tgggtggtgt tgggaggatt aggctaagta 783661 tcataattgg gggcaaaaga atacggagaa tgttttcgac gtgtgttcgt cttttctgta 783721 ttctcaccag ttctccacct ttcaacgaaa tttgtgttac agctcctatt gtaagaatat 783781 tttgtaacta tttgtaggtg tttctttatg attattgtaa aagggagaaa aatgagtatt 783841 atgtagcagt atcaaacgac aaatactggg catttatgct tatcgtttgt cacaatcgcg 783901 gaatgtttat tttagtgtgg ctggggtaga gtgttttatg tagacatata aagcgggagg 783961 ttatgaatca tggggaaaaa aattgcagtt gttttaacat attattttga ggacagcgag 784021 tacactgagc ctgcgaaagc ctttaaagaa gcgggacatg aactgactgt catcgaaaaa 784081 gaaaaaggaa aaacagtaaa aggcaagcag ggaacagcgg aagtgacggt tgacgcgtcc 784141 attgacgacg taaattcttc agactttgat gcgcttttga ttcctggagg attttcacca 784201 gaccagcttc gcgctgacga tcgtttcgtc caatttacaa aagcgtttat gactgacaaa 784261 aagccggtat ttgccatttg ccacggcccg cagcttttaa tcaatgcgaa agcgctcgac 784321 ggccgaaaag cgacgggcta tacgtccatt cgtgttgaca tggaaaacgc cggtgccgac 784381 gttgtggaca aggaagtggt tgtttgccag gatcaattgg tcactagccg cacaccggac 784441 gatataccgg catttaaccg cgagtcattg gcattgcttg agaaataaga aaaaacggac 784501 gctcttgggc gtccgttttt ttgttgctta ggcttgagca cctgtcagtt tcttgtacct 784561 gtaatacaag aaagcagctg cagccgttcc gatgaccgca atgccgaagt cgaatatgaa 784621 aatatgggcg atgccccccg cttttgcgat aagccctgtt gcaatcggca gcagaatcga 784681 tgcaagactt gaagcagtcg ctacaattcc ggtaacggtt ccttttcgct tccagaaaag 784741 ctctgtcatt aacgtaatgg taatttgaaa cacacccgca gttgaaaagc ctaagaaaaa 784801 ggcagtgatg tccagcacaa ctgggatatg aacggtcagc atgactgcga gcgtacataa 784861 agtaataata ggatataaga gcgttatgaa gacaggtttg acccatctat tcagcaaaac 784921 ggctaataat aaaacagatg ccagagatcc tatactataa tagctcagca attgtacaga 784981 tgctgattca gctaaaccgg ctgccttttg cgcgtagctc gggagccaga tttgagaaac 785041 cgtaaataaa gccgtggatg taaaaccgat gataatcagt gcggtgcctt ccttctgaaa 785101 aacgggttca gacaagaaaa cgggagattc ctgttggccg ctattagttg gtttcttatg 785161 ttttttagga aacgaaagcg ttgataaata aataatattc aggagataga ccgctgccgg 785221 cagataaaaa gcaaatccgt aaaacatgct gtggtctgct aaaaatgtga tcaaaagcgg 785281 caaaagtgcg gcccccacag acataaaggc tttaaccaag acatttgccg aaccggaagc 785341 agacggaaag agctcggtta gggccggata tgttccggca tccatggctg aattagcgac 785401 tccggctaat aaagcgaaca caaacgccag ctcatagctc ggtgataaag gaataccgac 785461 taaaaagacg gccataattc ccgcagaagc gacaacaagc ggctttctgc cgattttatc 785521 tgatagaacg ccggaaatgc cgtatgtcag cagtttgcca aacccgatag cggcaatgac 785581 ataactgatg ccggtcggat cggtattcca ctgttttgtt aatgaagaca tattggatgc 785641 gagaatgatg ttgaccatcc ccagaaagaa gtagttgata tacattccgg atgctgtttt 785701 gatagatgtc gtttgcatgc ttgtactcct tcaaatctta ttcgaacact ttgctgtttt 785761 ggtttgggga aatgataaaa aagactcgcc gagtttccgg ccagtctcca ttatttacga 785821 agcgaggcta attcttgagc aatcgcctgc atttcacttg ggctgaatga ttcttttttc 785881 atcaccattc tgtgaaggta cgtgaggtct tcaatcttct catcactgaa atcctccgct 785941 ttgattacgc cgacgttcag catgttcagc ttttgggaaa tctcttcaat catttgagtt 786001 aatgtttctg tatttgggct ggacaaaggg ttccatcctt tctatgcgca atataggtat 786061 gttttattct aacagaattc catcagaaaa aaaccctatt ctaaaagcag gctgttcatt 786121 ccaaaaaagt gaagacatca gttgaaaaga aaatgaacat cctactaaga tattcatgaa 786181 ggtttctttt tagagaaata ggggcaaaga atagggaggt tgcacatcat gataagcgtg 786241 ttatttgttt gtttaggtaa catttgccgg tctccgatgg cggaagcgat ttttagggac 786301 ctggcagcca aaaaaggatt agaggggaaa atcaaggcgg actcagccgg tattggcggc 786361 tggcacatcg gcaacccccc gcatgaggga acgcaggaga tattgcgcag agaaggaatc 786421 agctttgatg gcatgctggc gcgtcaagtc agcgaacagg atctggacga ttttgattac 786481 atcattgcaa tggatgcaga aaatatcgga agtctcagaa gcatggcggg ttttaaaaac 786541 acctcgcata tcaaaaggct cttggactat gttgaagatt cagatctggc tgacgtaccc 786601 gatccttact acacagggaa ctttgaagag gtctgccaat taatcaaaac gggctgtgag 786661 cagttgcttg catccattca aaaagaaaaa caattgtgag tgaaaggaga atttgcatga 786721 acaacgaacg tttaatgctg aaagggatat ttctcggagc tgcggcaggc gcggcgttat 786781 cactgctcca taagccgaca agacaggcgt gcgggatgag atggctgaca tgcaagcata 786841 aactttcact gtacaaaagc aacccagagc tgttaaaaaa cactgtcatc acaaaagtgg 786901 atgaggccaa aaagctcgcc cgaacgcttt caaaggaagt cgactttgtg aaccagcagg 786961 tgaaagagct gaagaaaaca acgccgcaag tgatggaact cgtgcaagaa acgaaagagc 787021 atttttcaaa aaaatgatca aacatgcgag gtgagacgac atgagttttt tgaaagagct 787081 tttcagcaga tacacccttc atgaaggaca aagtaaatca gcggagctgg cgtatttttt 787141 tctattgtca ctgtttccgt ttttgatttt tatgctgacg ctcaccgcgt atcttccgct 787201 ttctaccgat gatgttttag gagtcataga acaatatgct cccgccagtg cgatgtcact 787261 cgttgaatcc attacccatc aaaccttaaa taatcgaaat ggcggtttgc tgtcattcgg 787321 gattatcgcc gcattatggt ctgcgtctaa tggaatgaat gcgatcgtcc ggtcgctgaa 787381 ccacgcgtat gatgtggaag aaaaccgctc ttttatcatt gttcgtctaa cctcgatttt 787441 tttgacgatt gccatggtat ttacgatttt agtggctttg cttctgccgg tatttggccg 787501 ggagattgga aggctcgctt ctgactttgt cggcgcgtcg gatctgtttt tatccgtctg 787561 ggccgccatt cgctggggtg tcagcccgct tgtgcttttg attgtttttt ccgcgctgta 787621 tgtgattgcg ccgaacaaaa agctgtctct ccggtttgtc atgccgggtg cggtctttgc 787681 gactatcggc tggatcattg tcagcacatt gttttcattt tacgtcagca cgtttgcgaa 787741 ctatagcgcc acttacggga gcatcggggg aatcatcgtt ctgatgattt ggttttactt 787801 gagcggcatt ttaattatcc taggcggaga aatcaacgct cttttacata aacgtaaaaa 787861 gcttcctgat gaaaatccct accattagcg caccctataa acgaacttcg gttcaaaaag 787921 aagtcggggg gatatcgtga tgaccaagca tacgaaaaaa ggcggaagcc ataacaaaca 787981 aaactcgaaa agcaaatcga gccataaaac aagcggaagc gccaacggac aaaacggcta 788041 ccattagcat aaaagcctcc tgacatgatg tcgggaggct ttttgattaa gaagatgaag 788101 aataggtttc agccggtgac cagcttttcg gtttgcccag cacaagggcc agccacacag 788161 agctaagcgt gagagtaatg aagtagaaca agtttgcgct ttcaaatgtc tgcatatacc 788221 agccgccggc aactgggccg aggatgctac cgagactgaa tgtaatgccg caaagcaggt 788281 ttcccgccgg caggaggtga ggcggaagaa ggtctgtcat atagctgatg ccaagtgtaa 788341 aggttgatcc gactgccatt cctgcaataa aaaagcagcc gccgatcacg tagggcgaag 788401 gaaatacacc ggcgatgaaa aagcaaagag ccccagtcag taaaatcacc agcagcacat 788461 tccgcctgcc gtatttatcg ctgaggatgc cgagcggaaa ctgaaagata atgcttccaa 788521 tcgcaaatgc gggaaggatg atcgctactg cgtctactga tatccccaaa cggagcgcgt 788581 acaccggaaa gcttccgttc agcgccgttt ccagaaagcc atagccaaat gtaggcataa 788641 aggcaaccca cccaaacagc atggcctgat aaaatcgcct gaaactattg tctgatttgg 788701 tttcatgagg actggtttcc gggtatgcat tttgtagaaa gaaaacaaaa agccacgcaa 788761 acagactgat gcagccggac acgataaaag gaagcgacgg actcagcttg acaagcggca 788821 ccatgaacgg gcctgcggca aagccaaggc caaaggaaag cccataaata gacaggtttc 788881 ttccgcgatt ttgttttgat gacatggagg tcacccacgt ttgcgtagaa aagtgaagca 788941 tgtggtcgcc gattccaatg aacaggcgaa gcaggaacca gacccaaact gactgaagcc 789001 aaataaatcc gaataagctt aaaatgacaa tgcttccgcc catgacgatc agcggcttga 789061 acccgagctt tctgagcggt gcttccataa acggcgaagc caaaagcaca ccgatataca 789121 gcccggtcgc gtgcaggccg ttgatagcag cggattctcc atttgtttca aaaatgattg 789181 aaatgacagg cagcagcatg ccttgtgaaa acccggaaat ggaaacgagc aagacaagga 789241 taaagaaatg aaatcgtgac atcgtgtcag ttctccttat atggaatcta tgttgatcgt 789301 acaacgtttt ccaaaagcag gcaacctgaa aaaagcctat atcacgctat acatttgccc 789361 tcgtgtaatc atgaaggttt ttgtgaagaa taaaaataaa acaagtcata aaaaaggagc 789421 tatttcacca tgaatcgtat cttttttatt ttagtggcgg ccggtgttcc gctttctgtg 789481 attggcagtt tgatgcattg gccttccgcg gttctatttg cagtttattg cgtgacgatt 789541 atcgcgcttg caagctatat ggggagggcg acagaatcac tgtccatcat tgcaggaccg 789601 cgtatcggcg gtttgttgaa tgcaaccttc gggaatgcgg tggagctgat tatttccctt 789661 tttgcattaa aagaaggcct gacaggaatc gtgcttgcct ctttaaccgg ttcagtgctg 789721 gggaacctgt tgctggtagc gggcctatcg ttttttgtcg gcggtttaaa atataagcgg 789781 caggaattta atatccatga tgcccgccat aactccgggc ttctgatttt tgccatcatt 789841 gtcgcctttg tgattccgga ggtattctct gttggtatgg gaaacgccag caagctcaat 789901 ttaagcatcg gcatcagcat cattatgatt ctgttatatg tggcggcgct gtactttaaa 789961 cttgtcacgc atcggggcgt ttatcagccg aataatgccg ctcagactga agaagaggaa 790021 gagccagaat ggtcagggaa ggttgcgacg attgtcttgt ttgcggcaac gattgtggtt 790081 gcatacatat ccgaaaacct ggtccatacc tttcactcgg tggctgaaca gttcgggtgg 790141 agcgagctgt ttattggggt catcatcgtg gcgattgtag gaaatgcggc ggagcatgcg 790201 tcagcgatta ttatggcctt caaaaataaa atggacattg ctgttgaaat tgcagtaggc 790261 tctacgctgc agatcgctat gtttgtcgca ccggttctcg tcatctgttc tatctttttt 790321 ccgacaagca tgccgcttgt atttacattg cctgagctcg tcgcgatggt atcagcggtt 790381 ctcttgatga tcgcgatttc gaatgacggg gattccaact ggtttgaagg ggcgacactg 790441 cttgctgcat atgtcattat ggcgatcggc tttttccttc tttaacctga aaaaatgatg 790501 gataacaaca aagcgggatg aaaagactaa gggaaaatgc catagaaaga gtgatatgat 790561 gaaaaagcta tttcattcca cacttattgt gttgttattc tttagttttt tcggcgttca 790621 gcccatccac gcgaaaaagc agtttaaggt tcctaattct gtcgcaagca tttcaaagga 790681 aaacacgtat ccgaatgctt cacaggatca gccaatgctt cagccgagca agctggcaaa 790741 ggaattgctc gatcattctg aggtaaagat tgaaaatccg catctcatca aaatgctgaa 790801 tgaatccaac atatccggca caccgcttgc agtagggtac cgggcgacaa tatttctcgg 790861 gaaatgggcg ctcggctatg aatcaaatga aacagtcgca aactgggaat ataaaaaaat 790921 caatacaaac cgtgcggata accgcggcgg gaaagaaacg gctgaaatgc attatgccca 790981 ggaacagcag tacagagtga agggcggctt gacagctaaa gttccaaatg ctgaagatgt 791041 caaaagcatg atgatgcaaa aagcaatgaa gaaaacgaac ctcccgcttg catttgagac 791101 ggtcatcggg gctggcacaa aacgggatca gatttataaa gtcgctccta aaaaaatcgg 791161 ttatctacat gcatatgcac cggctgtgaa tgaaaaagga aaagtgactt acggagaagt 791221 gtacttagtg ctgaaaggaa ataaacgaaa actcgtcgtg aaaaatgtca cgtcacaggg 791281 aatcggcgcg tggattccgg ttcaagatca tgtcacgttt ggctttcagc tttcctcact 791341 gccaagataa ataaaaaact gattccaact cggaatcagt ttttttgttt attgggttct 791401 ctcgattcgg accgcttcct caagcatttg cacattgttt tggtagagct ggcgaacgag 791461 aacccgtctt actgcaaggc tggcactgaa ataatcatca tctttcacca tgcctttaac 791521 cgtaaattcg acgccgcgat tgattttatt caatgcggtg atgccgtgga tttgaaacgg 791581 ttctgtcgga ttgccgaatt catcccgctt caatgaatca cgaagctctt cattcagcat 791641 gtcacatgcc tcttccaaca cgctgtacac gcggtccgga tcttctttaa agctgataag 791701 aaaggattcg gtaatccgca taaaatcaat attatagttc tctatttgtc tgacctcgcc 791761 gttgctgatg gtgagcagct tcccgctcca ttcccggatt tgcagcgagc ggaggccgat 791821 ttcctccact gtcccgttga acaagttgtt gacggtgaca taatcgcctt tgtgcagctg 791881 gcgttcatat attaagaata caccagccag cacatctttg atcagcgatt gggcgccaaa 791941 accgatcacg atacctgcta cgcccgcccc ggccaatatc ttgccgaaat catgcacaaa 792001 taaagaaata acgtaaaaga taaaaccaat tgttgccgta tactgggtga cagaacggac 792061 aaggctttca atcgtttttt cctttttttc ttcaataaag tccgtccgtt taaaaaatag 792121 ctgtaccagc cggttgatga taaagacacc gatccaaagg ataacggcaa cgaggagaat 792181 atcgacgatt ttattttgaa aaatctccgt aagtgtttct ttcatccgca tctaactcct 792241 ggcttgacgt tttgtgaagt ctgtatcctg ataataactg tttttgacaa gaacattcgg 792301 tccgaggcac cggacattcg ggcagtggca actcagttct ttcgcaagct tggtctctct 792361 ccacttttca taggcggaag ggaggctgtc cgtctgaatg ttgccaagcg gcggggtatc 792421 accgaaatcg gtcacgataa tgtttccgtc gaaaatgttc acattcaggc gggatcggcc 792481 gtcagggtca tttcgcactg tgacgttttt cgccgcgcga agccggcgaa gcagcttttg 792541 gtcgtcttcg tccggactgc aggcataaaa cggcagcgtt ccgaacagca tccacgtatt 792601 ttcatcacga atatccagca agcggtgaat ggcctgtctc atctctttca ggctgaggga 792661 ttcaagagcg cttgcgaaat cgcttggata cattgggtgg acctcgtgac gctgacattt 792721 catatcttct gtgatttggc ggtgaatatg ctcaatatgc ggaagtgttc gtttgttcag 792781 catcgtttcc gcagatacca ttactccggc atccacgagc gtgcggctgt tttcgatcat 792841 tttttcaaaa tagcgcgcgc gctgttcgaa ggtcggtttt ctgtccatca tggcaaagcc 792901 gatttcagca aaatcttcaa ctgttcccca gttatgtgaa atatgtagca catcgagata 792961 cggaatgatc cattcgtacc gctcgatgtc gagggtcaga tttgaattaa tttgtgtccg 793021 cacaccccgt tcatgggcat atttcaataa aggaacaaca tattctttta ctgatttcaa 793081 cgaaagcatc ggctctccgc ctgtgatgct gatggatctg aggcgcggga tttcctccag 793141 ccgttttaac agaagatcta ttggcagagc attcgggtct ttaggctgca atgtatagcc 793201 tacagcacaa tgctcgcatc tcatattgca cagtgtcgtt gttgtgaatt caacgtttgt 793261 cagctgcatg tctccgtatt ggtcaacatc catataggct tcccaagggt caaactcggg 793321 cgtaatcgga cgcagcttcg tgttttgtgt catgactatc taactccttt ataaatgggc 793381 atactaacgc tgccaacagt taattttaga cctgatttgc caagatcgca agtagcgcgg 793441 cgattgaaaa acggcaaaaa atgagctacc ataataaaaa atgaatggag gaacagaatg 793501 gggaacgccg taaacaataa agatcagcag attgattatt taaagaacag acttgacatg 793561 tttatgaacg tcatcgattc attagaccct gaagcaaccg acgttgaaga tatagacagg 793621 cttatcagca tgcttgatga cctggaagcc aaatacgaac gttttaaaaa agattgggaa 793681 taaaaccgcg tgcccgccgc ggttttttta ttggcataaa gcaacagtat aaaacaaagt 793741 ctctatctgt aaaataagaa aaaatgcaga aggagcgctg gccatgaagt ggatgtgttc 793801 aatatgctgc gccgccgtat tgcttgccgg aggtgcagca caggcggaag cggtgccgaa 793861 tgagccgatt aattggggct ttaaacgaag tgtcaatcat cagccgccag atgccgggaa 793921 gcagctgaac agtttaattg aaaaatatga cgcgttttat ttagggaata caaaggaaaa 793981 aacgatttac ttaacgtttg ataacggata tgaaaatggc tatacgccaa aagtgcttga 794041 tgtcttaaaa aaacatcgcg taacaggaac gttttttgtc accgggcatt tcgtaaagga 794101 ccagcctcag ctgatcaaac gaatgtcaga tgagggccat attatcggca atcattcctt 794161 tcaccatccg gatttaacga caaaaacagc tgatcagatt caggatgaac ttgattcagt 794221 caacgaagag gtttataaaa ttacgggaaa gcaggacaac ctgtatttgc gtccgccgcg 794281 cggcgtgttc agtgagtacg tactgaaaga aacgaaacgc ctcggctatc aaaccgtttt 794341 ctggtcggtc gcttttgttg attggaaaat caacaaccaa aagggaaaga aatatgccta 794401 cgatcatatg atcaagcagg cgcacccggg agccatttac ctgcttcaca ccgtatcgag 794461 ggacaatgca gaagcgctgg atgacgcgat tacagatctg aaaaaacagg gctacacttt 794521 taaaagcatt gatgatctga tgtttgagaa agaaatgagg ctgccgtctt tgtaaaagag 794581 aaagacctct ccttaaacgg agaggctttt ctttatttta tacatttaat cagtgcggcc 794641 cagtccagat ccccgaagcc tttctcaatc ccgctttcaa aatggctctt ggccagctcg 794701 gcaagaggaa gatttgcaga aacccgtttt gcggcggcga gtgccaggtt ggtatccttc 794761 agccctaaag acattttgaa gccggccggc tcaaatttct gctcggccat aatggttccg 794821 taattttgat agactggaga accaaagagc gcgctggcga tttctaaaaa ttgtttttgt 794881 tctaagccgt atttctccat cattaaaaag gattcagata acgcctccag catggacaca 794941 agcaagaaat taatgctgat tttggctgca tttgccgtct tgctttcttc gccgacgtca 795001 aatatctgct ggctcaggct gtcgagcaga ggcttggcag cttgctttgc ttccgccggt 795061 ccggctgtta tgatacggag cgcggctttg gctgcggcat ccggtctgcc aaggacagga 795121 gcggcgagaa aaaattgtcc tttctctgca tgagccgctg cgagcttttc tgagaactca 795181 acactgattg tgctcatcga gatgtgtatg ccgttctctg ctaatccttc aagcagcccg 795241 tcttctccga atgtcacggt gctgacagaa tcatcatctg caagcattgt gatgacaata 795301 tcagcggact ttgccgccag ccgcggcgta tcagctgcct gtgcgccttc tgtgacaagg 795361 tcttctgtct tttgtttcgt ccggttatag acagtcaatt cgtagcctgc ttgaagaaca 795421 tttcgggcaa tgggctgtcc catattgccg agtccgatga cagcaatttt caatctaatc 795481 actccctgaa tattttttcc attataaaca atatgaacag aatatgcata gcgatcggct 795541 tacaacaaaa aagaacagct gctcgctgtc ctcatttaaa aatattgaac catcctttat 795601 gtacaaacca aatcagcatt ccaatcacaa gcgcggccat caggccaagt acagcgaaat 795661 atccgtattt ccaatgcagc tccggcataa agtcgaagtt cataccgtat acaccggcaa 795721 taaaggtgag cgggatgaaa atggttgata cgatcgtcag tgtcatcata atcgcattca 795781 tccggtttga gtttagcgtc acgtagctgt cacgcaagtc ggacgtcatg tcacggttgg 795841 attccacaat ttcagacaac tttaacaaat gatcatatat gtcgctgaaa taggctttcg 795901 tttcccgctg ctctttcaca tggtcaaggc ttaaaatccg gtagagcaaa tcacgcatcg 795961 ggataatcgt ccgtctcaaa tgcaataggt ctgttctgag atcaaacacc tcgttcatca 796021 gcgttccata cgttttgtgg ggacggcttt cttcaatttc attcagccgg tcttcaattt 796081 tatacacgag aggaaaatat tcatcaacaa gctgatccat gatcatataa gaaatatgcc 796141 cgggcccttt tttcaatatg tccggtgaag catacaaacg ctcccggact ttagcgatac 796201 cgggcgtttc gtgtaaatga aaggtgacga caaatttttc gccttgaaag atatcgactt 796261 cctccgtctc aagtgtttcc ttattcagcg catgaatcac gtaaaaacga tagccgtcat 796321 aatggtcaag ctttggccgc tgcatatgct ggaagcaatc ctcaatggca agcgggtgaa 796381 aatgaaaaaa atctctcaat aacgccgttt ccgtatcctc cgggccgtaa aaatcaaccc 796441 agtaccatgc aatatcaggc tgttccactc gttcgatcgg tatatttttc agcagctgat 796501 gctctgttgt gattgcggta atgttgatca taaacaaccc tccacctgcc attatatcat 796561 gcggtcttta tgagaaaagt atacggtact ctctgcctaa ttccagcggc atgttatact 796621 gaacaaaaac ggaaaaaagg gtggatctca tgtggaagga aaaagtatct gtcacgcctc 796681 cgtatcattt tgaccgcgtg ctggacaggc tgtctttaga ccccctcaat gctgttgatc 796741 gagaggcgag ggaagtccgt gtgccaatca gaaatcaagc gggggacgta tgtattgtaa 796801 aggtacaggc gttaggccat gcgggcgagc ctgagttcct cgtcagcggg gaaacggatc 796861 agggagaaat gatgaaggaa atcaagcgga tttttcaatg ggaaaatcat ttgcagcacg 796921 ttctggatca tttttcaaaa acgagcctgt ccgccatttt tgaagagcat gccgggacgc 796981 cgcttgttct ggactacagc gtgtacaact gcatgatgaa atgcattatc caccagcagc 797041 ttaatctttc cttcgcttac acgctaacag aacggtttgt tcatgcgttt ggcgagcaga 797101 aggatggcgt gtggtgctat ccaaagccgg aaacgattgc ggaactcgat tatcaggatc 797161 tgcgtgatct gcaattcagc atgagaaaag cggaatacac cattgataca tcaaggatga 797221 tcgcagaagg cacactcagc ttgtcagagc tgccgcatat ggcggatgaa gacattatga 797281 agaaactgat caaaatcagg ggtatcggcc cgtggaccgt gcaaaacgtc ctcatgttcg 797341 gacttggccg tcccaattta ttcccgcttg ccgatatcgg cctccagaat gccatcaaac 797401 gccactttca gctggacgat aagccggcaa aggatgtcat gctggcgatg agcaaggagt 797461 gggagcctta tttaagctat gcgtctttgt atttgtggag gagtatagaa taattcgtct 797521 gacaatgaag gaaatcctgc aaacgtgtta tactagaaag atgtgaaaaa accatttcac 797581 tttctgccat ccgcagaaag cttcatatag aaacggagag aacaacgtga accaacaaaa 797641 gaaacaggcg cccgtcgaac tgaaggtcgg acaaactttt ccgctgacga ttaagcgtct 797701 cggcattaac ggagaaggtg ttggctattt taagaaaaaa gtcgtcttcg tgcccggcgc 797761 gcttcctggc gaagaagttg ttgtgcaggc cacaaaggtc cagccgaagt tttcggaggg 797821 ccgcattaag aaaatccgca aggcatctga gcaccgggtg gcaccgcctt gccctgttta 797881 tgaacaatgc ggcggctgtc agcttcagca ccttgcatac agccagcagc ttcgggaaaa 797941 acgtgatatc gtcattcagt ctcttgaacg ccatacgaag tttaaagttg aaaacatgga 798001 aatcaaagaa acgattggca tggacaaccc gtggaattac cgcaataaaa gccaattcca 798061 gatcgggcgc tcgcaaagcg gcagcatcat cgccggctta tacggccttg attctcatga 798121 tatcgtgccg attaaagact gtatcgttca gcatccggca acgaacaaaa caacaggcat 798181 cgtccgccgc attttagagg acttcaatgt gtctgtttat aatgaaagaa aacgaaaagg 798241 cgacgttcgc acgatcgtga cgagagtcgg ctttgaaaca ggcgaagtgc aggtcgtgct 798301 tgtaaccgca aaagaaacgc ttccgcacaa ggaagaaatc gtcaaagcga ttcaaaagcg 798361 attgccagag gtcaaatcca ttattcagaa tgtaaacggg gcgaaaacct cagtgatttt 798421 tggtgagaaa acaaaacagc tcgccggaaa aacagtgatt caagaagtgc tcggcgacgt 798481 atcttttgaa ttgagcgccc gcgctttctt ccagctcaat ccggaacaga ccgtcaagct 798541 gtatgatgaa gtgaaaaaag cggcgcagct gaccggaaaa gaaaaagtcg ttgatgcgta 798601 ttgcggcgtc ggcactatcg gcatgtgggt tgcggacgga gcgaaggaag tccgcggcat 798661 ggacgtcatc aaggaatcaa ttgacgatgc taagaaaaac gccaaaaaac acggcatggc 798721 aaatgccaca tacgtaacag gaacagccga gcactggctc ccgaaatgga cgaaagaagg 798781 cttccgcccg gacgtcgtca ttgtagaccc gccaagaacg ggctgtgaca gcacgttctt 798841 ggacacgatc aaaaaagtca aaccgaaacg ctttgtctac gtttcctgca atccatccac 798901 gcttgcgaaa gatttgcaga cgctgtcgaa ggactatcgc gtggactata ttcagcctgt 798961 cgatatgttt ccgcagacgg cgcatgttga agcagtggcg aggcttgtat taaaatcgtc 799021 taactaaaaa gaacatttcc cagtcataaa atagttttcc taataagacc tggatttcgg 799081 taaaataaac aattccgatt tccgggtctt tttcgtgcgc agctcttgtc ctaacggtct 799141 gttctcaatt ttatcttcct tcttttcgcg gagatcttta ttttaactgg cgaaaagaat 799201 tgaaaaaacg tgttgaaaag caggtgaaaa aaagcgttat ttaaccggaa aaatatcctc 799261 ccagtatgtt taaaatacat gagtagaatg atgtaaaatc atagatgtat tttcataatt 799321 tgtaaaatta tatattgact tgcagttatt acgtgtgaaa tattgatgat aggaatataa 799381 ggaaagtatg gcgtatatca tttcaagagt cattcgatgt aaaaagttga aacattgtaa 799441 taaatgaaag aggtgaaaat gatggccaac cccattttaa aatgcataac gtatgagcac 799501 tacaacaatt aaataatagt gccgagacga taacaactat tacagtaata cctacaatgg 799561 ttatatcctt gcgacaatca tgcttcataa tataatgatt ttagattgac acttggctaa 799621 aaagtattgc agagaaggaa atggataatt aaatggataa agtatataaa agaagttggt 799681 ttcaaacatt tttggcattt ttagtatctc agctttattt taattttgta gaattaacgg 799741 gatggggtcc taagtataga gaaatgaatg gattcccagc aaacatagtt gaactagatt 799801 tctttcaaac atatctttca ttctatgata atccatggtt taatattatt actgttttct 799861 tgggagtttt cactattata caaataatta cagggataac aaaggatatt cgaaattaaa 799921 gcaataactt ctgatgcctt atttaatgat gaaagaaaat gtacactttc ttaattatct 799981 tatgagtgaa gactgcgaca cttagtcagc agtctatttt atggttctgg atcaggatta 800041 ccgaattata accctataca aatatatagt aggttgccac ttgctgcgtt ggttattttc 800101 taaatcatga gcaaatccca aatgattcag attgaagttc ttgaattctt ttaaataagg 800161 gtttattttc tcttctcatc ctctttactc catgtgattc acaagtggta gcagcttaag 800221 taggtttttt cattctcttg agtactcagt tataccaccc ccaactcaat ttgctttatc 800281 tctattagtt tttccgcaaa tatgatatag agatacggat atggtgtagt gttaaatatc 800341 ttatcttcaa taacagggca attattttgc gttggtaata tggagaactc atatgatatt 800401 ctatttaggt tggaatcctt tttatccaaa aagttcaaaa gcaaggccac taagaaagac 800461 gaaggtcagc gccagttaac cagaatataa aaaatagggt agataatcat cccacgtgaa 800521 atcttcaaaa tttactatag attgataaga aatgctttcg catgcgataa gtgtaaaaga 800581 agcatggtca gtttttaatt tgggataaag gttcagccgt atcccataat gaaaggattt 800641 gatttttgtt atgacagaaa atttctggcg tgaattacca cggccgtttt ttgtactggc 800701 accaatggaa gatgtgacag atgttgtttt ccggcatgta gtaagtgaag caggcagacc 800761 ggatgtgttt tttacagagt tcacaaactc agagagctat tgccacccgg atgggaagga 800821 tagcgtgcgc ggccgtttga cttttacaga ggatgaacag ccaattgtgg cccatatatg 800881 gggagataag cctgaaaact tccgtaaaat gagtattggc atggcagagt taggatttaa 800941 aggactagat atcaatatgg gctgccctgt gcctaatgtg gcggggaatg gaaagggaag 801001 cggccttatt tgccgtcctg cagttgcggc agaattaata caagctgcaa aagcaggggg 801061 attgcctgta agcgtgaaga caagacttgg atacacggat gtggatgaat ggcgcgagtg 801121 gctgacacac attttgaaac aggatattgc gaatctttct attcatctgc gtacaagggc 801181 agaaatgagc aaagtagatg cgcattggga gctcatccca gagattaaga aacttcgtga 801241 cgaggtggca ccagatacat tgctaacaat aaacggggat attcctgacc gtcaaactgg 801301 cttgaaactt gctgaacaat acggcgtcga tggaattatg atagggcgcg gtatttttac 801361 aaatcctttc gcttttgaaa aggagccgaa agagcatagc agcaaggaat tgcttgatct 801421 cttaaggctg catctggatc tccatgatga atattcaaaa gaagaagccc gtccatacaa 801481 gcctcttcct cgctttttca agatttatct ccgcggattc cgaggggcaa gtgaattaag 801541 aaatcaatgc atgaacacaa agtcaacaga tgaagtgcgt gcattgctcg acgactttga 801601 gagaaagtat cttgatggga tagagtaaca gcagtgcttg attcaaaaaa ggctaacaaa 801661 ataaagggat ttttacacaa ttcttgacta aaataaacct ggattttcgg taaatccggg 801721 tcttttttgt acgcagcttt tactcagcct gtcttttctc taatttattg taagaaaata 801781 atggtatatt tagtggagat atcatataaa gggggagagg aaaatgaaac ggctatgcat 801841 catcccctgc ggcaagaaaa aaatctggga tgtccagcct gatgccgggc cggtaagagc 801901 agaggacgct tatctcagcc cgtttcatca ggcgtgcgag cggtatgcaa aaacattttt 801961 cgatgagtgg gtgattttgt cggcgaagca cgggttcctc cgccctgatg atctcgtttc 802021 gggaaattac gatgtcactt ttggcaccgg tcatccggaa atcatgacag cggacgagct 802081 gcgccgtcaa tttcacgaaa aaggcttttc tgatatcgaa gagctagtca tgcttggcgg 802141 aaaaaaatat cgaagcgttc taaacgccgt catcggagaa caccagcata tcagctggcc 802201 gctatcatca tacaaaggca taggctatat gctccaagcg ctgaaccggg ctgttgaaga 802261 aaagcatgaa ctgtagcacg tacatatgag gaaaagagtg ggaacatgaa aaaacttgtg 802321 tttggcttgc ttgccattgt gttattcgga tgcggactat atatctatca tgtatggttc 802381 ggtgatccat tttcgaaaaa tgctgcagaa cagaagctag tgtcttatgt gaaacaaacc 802441 tatcctaaga aagaaatcaa gatcacgaat ggggtatata acgctaaaac gtctgaatat 802501 gtatttgaag caacctccca atctcatcgc tacccaatgt gtacgaaggg atttctgcat 802561 cctaaagtaa cgtgcgatgg aattgaagaa gcgtataccg aatcagtagc aaaacatgta 802621 aatgaagaag caacgaaggc aatcgaagca gatctgaaaa aagcggttcc tcgatttata 802681 aaagctgatg ctgctttgag tatcgaaaac ggacagttca cgttagatac aaaatggaac 802741 aaaaagctgg ctgaaaaagc gcctatgagc atgacgattc agttagacgc cagcgggtta 802801 tcaaaaacag atgccgcaaa gatggcggaa acggtcagaa aaacgcttaa tgaaaaggga 802861 tatacatact caaacggcac gatagactgt atgcagaagg acggggacgg cggtattgga 802921 tatgtcaaat attcaattga ttttctttca aaagcagcta ttcagtcaaa cgatgcagag 802981 gaactaggaa gttaaaaaga tttccaagga aataaatacg tcgatcattg tcaaaggccg 803041 ggtgatatcc ggtctttttt ttgcatgctg taaaacgaga caaatgaatc agtttgagac 803101 aaaacgagac acacgtctca aactgtctcc aaagtgaaga tgagaagact gattttacgg 803161 gctcaaaaga ctggcacact tcttgcattt ataatggtga accctaaata gaaggaggcg 803221 cacaaaatga aattgttaaa acgagaaggc ttgtcattaa ctgaggaaaa agcgctgtgg 803281 atgtaccaaa agatgctgga gatcaggggc tttgaagaca aagtgcatga actgttcgcc 803341 cagggagtgc ttcccggatt cgttcattta tatgccggtg aggaagccgt ggctgtaggg 803401 gtgtgcgctc atttacatga tggcgacagc attacaagca cccacagggg acatggacat 803461 tgtatcgcca aaggctgtga cctggacggc atgatggcgg aaattttcgg gaaagcgacc 803521 ggattgtgca aaggcaaggg cggttctatg cacattgcgg atcttgataa aggcatgtta 803581 ggcgcaaatg gaatcgtcgg gggcggcttt acgctcgcat gcggatcagc gctcacggct 803641 aaatataaac agactaaaaa tgtaagcgtt tgctttttcg gggacggggc aaataaccaa 803701 ggtaccttcc acgaagggct gaatttagcg gctgtatgga accttcctgt cgtatttgtt 803761 gctgaaaaca acggctatgg cgaagctacc ccatttgagt acgcatcagc ctgtgattca 803821 atcgccgatc gggcggctgc ttataacatg ccgggggtta cagttgacgg caaagatatt 803881 ttagcagttt accaggcagc cgaggaagcg atagaaagag caagaaacgg cggcggcccg 803941 tctttgattg aatgtatgac ctacagaaac tacggccatt tcgaaggaga tgcccaaacc 804001 tataaaacga aggatgaaag agttgagcac cttgaagaaa aagatgccat tcaaggtttt 804061 aaaaactacc ttttaaaaga aacagatgct aataagctgt cagacattga acagcgtgtc 804121 agcgaatcga ttgaaaaagc cgtctcgttc agcgaagaca gcccatatcc aaaagattcg 804181 gagctgctga cagatgtgta tgtgtcatat gaaaaaggag gaatgtaaga gatggcgaga 804241 gtcataagca tgtcagacgc gatcaatgaa gcaatgaagc ttgcgatgag aaaagacgaa 804301 aatgtgcttt tgatcggtga ggatgtcgcc gggggagcgg cggtcgatca tttgcaggat 804361 gatgaagcat ggggcggtgt attaggggtc acaaagggac tcgtacagga attcgggcgt 804421 acaagagtgc tggacactcc gatttctgag gcaggctata tgggagcggc tatggctgcg 804481 gcatcaaccg gtttgagacc gattgccgag ctgatgttta acgattttat cggcacgtgc 804541 tttgatcagg tgatcaacca aggggcgaaa ttccgttata tgttcggcgg aaaagcgcaa 804601 gtgccgatta ccgtccgcac cacatacgga gcagggttcc gggccgctgc ccagcattca 804661 caatcgctgt atggcctttt cacgagcatc cctggactga agacagttgt tccatccaat 804721 ccgtatgatg ccaaaggtct tttgcttgca gcaatagaag ataatgatcc ggtgtttttc 804781 tttgaagaca aaacgtccta caacatgaag ggcgaggtgc cggaagatta ttatacaatt 804841 cccctcggaa aagcggatat caaacgcgaa ggcaatgatg ttacgctctt tgcagtcggc 804901 aagcaggtca atactgcgct tgaagcggct gcacagcttt cagagagggg catcgaagcc 804961 gaggtccttg atccccgcag tctgtctcct ctggatgagg atgcgatttt cacatcgtta 805021 gaaaaaacaa accggctgat catcattgat gaagccaatc cgcgatgcag cattgccacg 805081 gatattgctg cgcttgtcgc tgacaagggc tttgatttgc ttgatgcgcc gattaaacgg 805141 attacagcgc cgcatacacc ggttccgttt tcaccagtgc ttgaagatca atatttgccg 805201 acaccagata aaattgtcag cgtcacgctt gaattgcttg gcgagccggc attgaattaa 805261 aggggggaca caaatggcgg taaaagtagt gatgccaaaa ttgggaatgg ccatgaaaca 805321 aggggaagta tcgatatgga ataaaaaagt aggcgacccg gttgaaaagg gagaaagcat 805381 tgccagcatt caatcggaga aaattgaaat ggagatcgaa gcgcctgaaa aaggaacgct 805441 gatcgatatc aaagtgaaag agggagaaga ggttccgccc ggcacagcta tctgctatat 805501 cggggacgcc aatgagtcgg tgcaggaaga ggcgggggcg cctgttgctg aagacaatat 805561 gccgcaagcc gtccagcccg tcaaacaaga aaacaaaccc gcagcctcca aaaaagatcg 805621 aatgaaaata tctccagtcg ccaggaaaat agcagaaaaa gcaggattag acctaaaaca 805681 actgaaagga actggaccag gcggacgaat cgtgaaggat gacgtaacaa aggctcttgc 805741 tgaacagaaa aaagatcaag caaagcctgt ttcggagcag aaagcgcagg aaatcccggt 805801 gacaggcatg agaaaggtca tcgctgcccg aatgcaggaa agcctggcaa acagcgcgca 805861 gctgacgatc acgatgaaag ctgatatcac caagcttgcc actcttcaaa aacagctttc 805921 accaactgcg gaagagagat acggcacaaa actgacgatc actcattttg tctcaagagc 805981 cgccgttctc gctctgcaag ctcaccctgt gctgaacagc ttttatcaaa atgagcgcat 806041 catcacacat ccccatgtgc accttggtat ggctgtagcc ttggaaaatg gcttagtggt 806101 gcctgtcatc cgccatgctg aaaagctatc gctgattgaa ctggctcaat ccatctcaga 806161 aaatgccaaa aaagcacgcg agggacgtgc gggaagcgaa gaactgcaag gatctacttt 806221 ctccattaca aaccttggcg cgtttggagt tgagcatttc acaccgatac taaatccgcc 806281 ggaaacaggc attctcggca tcggagcaag ctatgacaca ccggtgtatc aaggggagga 806341 gatcgtcaga agcacgatcc tgccactcag cctgacattt gatcacagag cgtgtgacgg 806401 cgcccctgcc gctgcattcc tgaaggcgat gaaaacatat ttggaagaac ccgcagcatt 806461 aattttatag gaaaagcagg tgaaaacgac atgacattag ccattatcgg cggcggacct 806521 gcaggctatg cggctgcggt ttccgcggca cagcagggca gaaacgtgct gctcattgac 806581 aaaggcaagc ttggggggac ctgcctgaat gaaggctgca tcccgacaaa gtctttgtta 806641 gaaagcgcaa acgttcttga taaaatcaag catgccgaca gctttggaat cgaacttccg 806701 gcaggtgcga tatcagtcga ttggagtaaa atgcaaagcc gaaaacaaca ggttgtcagt 806761 cagcttgtcc aaggcgttca gtacctaatg aagaaaaatc aaatacaggt tgtaaaggga 806821 acagcctcct ttctttctga aagaaagctc ttgatcgaag gagaaaacgg aaaagaaatc 806881 agagaggcgg accaagtatt gattgcctcc gggtcagagc caatcgagct gccttttgcc 806941 ccatttgacg gcgaatggat cctcgacagc aaagacgcgc tttctctttc cgagattccg 807001 tcttcactag tcattgtcgg cggcggtgtc atcgggtgtg agtatgcagg gctgttcgcc 807061 agattgggat cgcaggtgac catcattgaa acagcggacc ggctgatccc ggctgaagat 807121 gaagatattg cccgtctctt tcaggagaaa cttgaggaag acggtgtcga agtgcatact 807181 tcatccagat tagggcgggt ggatcaaacg gccaaaacgg caatatggaa aagcggtcag 807241 cgagagttta aaacgaaggc cgattatgtg ctggtggcga tcggcagaaa accccgtctt 807301 gacggattgc agctggaaca ggccggagtt gatttttctc caaagggcat tccggtgaat 807361 gggcacatgc agacgaacgt gcctcatatt tacgcgtgcg gagatgctat agggggcatt 807421 cagctcgcgc atgccgcttt ccatgagggc atcatcgctg cttctcatgc ttccggaagg 807481 gatgtcaaaa tcaatgagaa acatgtgccg cgctgcatct atacgtcccc ggaaatcgcg 807541 tgtatcggaa tgacagaacg acaggcaaga agcatatacg gggatgtgaa gatcggcgaa 807601 ttttcatttt ccgcaaacgg caaggcgctc attaaacagc aagcggaagg aaaggtcaaa 807661 atcatggctg aaccggaatt cggcgaaatc gtgggtgtct cgatgattgg cccggatgta 807721 accgagctca tcggccaagc ggcagcgatc atgaatggtg agatgacggc agatatggcg 807781 gagcatttta tcgccgccca tccgacttta tcggaaacat tgcatgaggc gctgttaagc 807841 acgatcggcc ttgcggtaca tgcataataa aggaaaaagc aggcgcatgg atataaggcg 807901 cctgcttttt tattgttgaa agcgctttat ttttccccta caatagatga aaacggcgtg 807961 taagggagga gcgatcaagg aaatgaattc ggtcccaaac gatttgcaaa cctggaaacg 808021 ttttgtgaaa gacggtgtgc ttgacgaagc ccgattaaga aaacggattg cagagtcatg 808081 gcatcgctgc aaaaaagctg aggtcaatcc ttatttagaa aaaggcccga aggttttaca 808141 gcaaacggag ctggatcagc agtcaaaaaa acattcattc ttcttgacga ccgcaaagcc 808201 ttacctcgaa aaactgctgc ctgccataaa agaaatggaa atgatggcgc tgttaattga 808261 ttcagacggt gttgttctgg cattggacgg ccatccgcgc gcgctctatg aagccaaacg 808321 catcaatttc gtcgaagggg catgctggac agaaacggct gtcggaacaa atgcgattgg 808381 cacggcgctc cacatcagcg agccggttgc aatacaagga tcagagcatt actctatcgc 808441 ttcccatctt tggaactgtt cagctgctcc gattcaccat gaggatggca gccttgcggg 808501 tgtaattgac atatcatgcc cggcggcagg cgcgcatcct catatgcttg gtattgccac 808561 ggcgattgcc tatgccgctg aacgggaact cgcagctaaa agccgtgaga aagagctgga 808621 gctgatcagc cgttttgggg agagagctgc atccagtgtg ccgatggtgc tctgtaatac 808681 caagcagcac atcatcagtg cgagcatgcc gattcgaacc tcaatgccgg attggcaggg 808741 ccggcacctg tacgagttga aggaacgggg ctattcaatc gaaaatgctg tcaccatagg 808801 agatggcggc acttgttttt atctttcgga acaaaagaaa aagaaggcgt ttcgattcaa 808861 tggagtgatc gggcaaagcg gccgatcgca agcgatgctg atgcaccttg aacgagcagc 808921 tgcgacggat gcatcggtct gtttgtcggg tgaaacgggt acggggaagg aggtcgcggc 808981 tcgcgcgctt catgagaaca gtgagagacg gcacggtccg tttgttgctg tcaattgcgg 809041 agcgattccg tctgatttga ttgaaagcga actgttcgga tatgcagagg gcgcttttac 809101 gggagcgaaa cgaaatggct ataaaggcgc ctttcaaaaa gcgaatcaag gcacattatt 809161 tttagatgaa atcggagaaa tttcccactc gatgcaggtt gcacttttac gggtgcttca 809221 ggaacgcaag ataacgccaa tcggcgggac gaaagaaatt ccggttgata tcagagttat 809281 tgccgccaca cattgtgatt tacgcgagct tgccgaaaac ggaaaaatca gagaggactt 809341 gttttaccgt cttcatgtct atccaattga actccctcca ttacgcgatc gcaccgagga 809401 tatcccggat ctctttgagt actacaaaca gaagaatcat tggccaggcg atcttccttc 809461 tgatttttgt aatgtgctga agcaatggaa gtggccgggg aatatccgcg agctgtttaa 809521 tgtgtttgaa cgtctttcta tcagatttcc ggacggccgg ctgagagatg aatcgcttcc 809581 cgctttactg gaagccgctg gattgccggc cagctctgca gaaaaaaagc cggctgctgc 809641 cggcgtgctt acttttcgtg agcaaatcca aaaggatatg atgatcaaag cgcttgaatc 809701 tgcaaaagga aacgtctctc aagccgcaaa aatcagcggg atcccccgaa gcactttcta 809761 caaacgcctg aaaaaattca acttgtccgc tgaatcataa agcatacttc cttcaggaaa 809821 tggaaacgtt atgtattgaa ggagggtgtt acgatgaata ttcaaagggc gaaagaaatt 809881 gtagaatctc ccgacatgaa gaaagtaaca tataacggcg ttcctattta cattcagcac 809941 gtaaatgaag aaactggaac agcaagaatt tatccgcttg acgaaccgca agaggagcat 810001 gaagtgcagc tgaacagctt aaaagaggat taaacaaaaa tggcccgctt cataagcagg 810061 ccattttgtt atccgcgcgg cgcaaataaa ataacacaga caccgatgag acaaatgaat 810121 gcgccgatcc agtcatacag atcaggtgtt ttccggtcaa caagccatcc ccacaggacc 810181 gcaagcacga tgaatactcc gccataagcg gcgtatacac ggccgaaaga tgggaaggac 810241 tgaaacgtcg gaagaatgcc gtatacaatg aggatcagcg ccccggcgat tccgtagcca 810301 gctggctttg cctctctcag ccatagccaa accagatatc cgccgccaat ttcagcaagc 810361 cctgccgcga gaaataaaag aatggtaatc agcatcatga gcactcctca atttgcattt 810421 atctttcatt atagaggagg agagctttta aagcttcgga tgattctcaa attccttcaa 810481 atacgctttt cgctgaacct ctgtaaattg gctgatccaa ttgttttgag cctcttcatt 810541 caaatgggga aggatatagc gttcaaccgc ttcgaaaaac agcggattcg tgatgatgtt 810601 ccaggtcggg attcgaacga ttttgccgtc tgttttctcg atgataatat cctcaaaaaa 810661 gatccctttc aaactgtatt gatggcgtcc catataaagc cgcttcacct cggaaaacag 810721 cacgctgcgc tttctcaaga agatttcgcc actaggtccg gtctttatgg tgaaaatgac 810781 atttccacgg cttgtgaacg caggaaaagc cataaagaat gtgatcaatc cataaatcat 810841 cgccagtaat ccgccgccca aataaagcag ggcatattta gattcaaacg tgagggcttc 810901 agacaccagc cagactccca caataaaggc gccccctgta gcgaggaaca gccaagccct 810961 tagaaacatc atgcttttta cttcaatcat gtgctgcccc taaagcttcg gatgattctc 811021 aaattccttc aaatacgcac tgcgttggat gtctgtaaac tgtccgatcc aattgctttt 811081 cgcctcttca ttcagatgtg gaaggatata gcgttcaacc gcttcgaaaa acaacggatt 811141 cggaatgatg ttccaagtgg gaatgcgaat ggtcttctga tccacggttt ggatcaatat 811201 atcttcttgg aagattcctt ttagactaaa tttatggcgg ctcatctcaa ttttcttgat 811261 atcagtaaac gtaacagaca ctttgtcagt gaacacttct ccattttttc ctgtcttgat 811321 gcggaaaatg gtatttcccc gcggggtgaa agccggaaag aagatgataa ataaatataa 811381 acaaaacaag gtgaacagaa agccagcagg aatggctaat aggtaatatt tcgtttgaaa 811441 cgtaataccc atataaaaga gccacaaaca tgctaatccc ataccggcag atccgacaaa 811501 agcccatatt ctcaggaaca ttttgctttt gacttcaatg atttcttggt ttttcaatgc 811561 ttttctcctt ttgttaattc aattcttatc attttgaaat gatttgattt acaacatcct 811621 tatgagcagg gaggatagaa aattcattct gggtgatgcc tgtgacaagc caagtatggt 811681 gggcccccgg caggacgaat gccatgtcag ccacttcagg agtgttatct tttccatatg 811741 ccagacgcat aagtgtatcc attttccctt tccgcaaagc cagatcattt gcaaatcggg 811801 taacgtcctc ttggtggtca tgtttttcaa ggaactcttt tagatatgaa gggttgtctg 811861 aagcgccctc caagagtttt tcaaattcat ttgatgtcaa tgttacaatc gattctcttt 811921 tatcctctgt atctattata tgtaaaaact catctgtctt agcaagtaac ccttcacttg 811981 attccatttt tgtaatgcga tggacttgtt catcaaaaag gagttcgtga gagtaggtgc 812041 cgaattttga tacatggcat gacacattct gttcggcacc ttgcccgtta aatttagaaa 812101 gcttcactgt atagtcagcg tcgtttaata catggataaa cggacagtac tcgtccttta 812161 accgatattg atggttccga tattccgctg catccttggc taagagtgag cggcacgcgg 812221 cttcaaataa ggcgccgagc tgttcatctt ctatttccgg aaaataggcc tgcttcaagg 812281 ccattccctg ttcaaaaaac ccttcgctgt aaaagcaaaa caagagttct tctatgctaa 812341 ttgtaaactg cttcattgtt tattctccta tccaaatgaa aatttccctt taaggaaatg 812401 ggttgcgccg tgtataagcg aatccgctgt tttctttgct ttttccattc cttttttcgc 812461 gctgtctatc cctttatgta tcgatttatt cgccgcatct atgccgtcat tcactgattt 812521 gacgactttg ccggctgatt ccagcccttt tttggctgta tcaacaacag catggatcgg 812581 ttctttcagc tttaaggctg ctttttcagc aaaaccggct gtatatttgg cgatttgttc 812641 tccgacgact ccgccaatgt atgaacctgc tgccccaaga aggacagtac ccacaggtcc 812701 tgcaaagctt ccgattgcac cgccgatgac agcaccagct gtggcaccgc cggcaacaaa 812761 aatcgtatta ttcacagcat tcccgacggc cttggcgttt tcacgcttga gaacttccgg 812821 tttatcctgg tattttgcat aattttcagc aattttcacg cctgctccga atgtttcggt 812881 cgctccggta atcagtgtgg cggtaatggc atttcctttc gcgaatctca agcccgtttt 812941 tcccacatcc ttcaaagtgg agcgtacgcc ggcttcatta agaaatcctt ttgtgtagct 813001 tctgacgctg tttgaaaaat ccaccgtgtc ctgaggaaag tattttgtaa actttttatg 813061 taccaaatct gaaaatggac ggtttgtctt tttcaacaaa tatttaggat tcaaaagcac 813121 tcttgccgct ttttgataac gtgagctgtc aacggccctg gaaatatcca agagcagttt 813181 tgagtgctgg gctgtatgca agccgcttgg ttgtttcaca aatttcgtaa gccctaatcc 813241 gtaatatttt ccctgcgtca gcataagagc ggttaagctt gtcatcgtac cgtatttgtc 813301 gtaggcattg tagagctttc gcaaaatatc atcttgttcc acaaatttat cgcctgtttt 813361 tctgatgaaa atctcattgt cactcagctt agtgacgagc gcctttcctg agctccacgc 813421 atcgcccact ccagaaaaac agctgctgta gcggggatcg cattgcaaaa tcatctgccc 813481 cagctccaca tgcaggtcct tatatttgtt ttccatatca gttaattcag tgactacatc 813541 atttgcaagc tgttcgagct tatccggatc aactgcaatg tttcctgaca caccgttcac 813601 ctcccgagtt tatgtctttc ctctcttgct ttacgctcca gttcttccat tctggcaatt 813661 tcagcttttc gttcttctat tttgacagcg gcagccttca gctcttggct tgtttcaagc 813721 agctcctgtt cgaattgatc gtaggcggct ttcgtttcct cgaaatcctg gtcaaacgaa 813781 tctcttgctt tgccctgcca agcatctccc aatgcagata accgggattc aagcagcatt 813841 ttggagcttc tgacctcttc tgcggccgca ctatacttgt ttgccagctc aatgacttta 813901 tatgagtcca acttttgtcc cctgcctttt ctaaattcac gcacaattgg atgttttata 813961 taaatgatta taaataattc ggcatgtatc cgaatcgtac aaaagaacct tttcataaga 814021 attggaaggg cgtatattca cttaaaattc acagttggtg agactttaag attacaaaaa 814081 aggtaaaaaa accaaatctc tcagacataa ggcaaatgag aaatttcccg ctctatggga 814141 aaaaacacta aagttgatca aatgacctaa gtgcgccaaa cgtgttacgg gacgagctat 814201 ctcatggtat aaatggaatt gtaaacgtta tcaaggaggt cgtcatatga agaaaaaatc 814261 attctcaatc gtaatagcgg gcggagggag cactttcact ccagggatcg tactcatgct 814321 cttggaccat ttggaggagt ttccgatcag aaagctgaag ctgtatgata atgataagga 814381 gagacaggat cgaattgcag gcgcctgtga cgtttttatc agagaaaaag cgccggatat 814441 tgaatttgca gcgacgactg acccggaaga agcttttaca gatgtcgatt ttgttatggc 814501 gcacatcaga gtagggaaat acgcgatgcg cgcgcttgat gagcaaattc cgttaaagta 814561 cggagttgtc ggccaggaga cgtgcgggcc gggcgggatc gcatacggta tgcgttcgat 814621 cggcggtgtg cttgaaatat tagattacat ggaaaaatac tcgcctgatg cgtggatgct 814681 caattattcc aatccggcgg caattgtggc tgaagctacg agacgcctta gaccgaattc 814741 taaaattctc aatatctgtg atatgccggt tgggatcgaa gaccggatgg cgcaaattct 814801 tggcttatcc tcaagaaaag aaatgaaggt ccgctattac ggattgaatc atttcggctg 814861 gtggacatcg attcaggatc aagagggcaa cgatttaatg ccgaagctga aggaacatgt 814921 atcccaatac ggttatattc cgaaaacaga ggctgaagct gtggaggcaa gctggaatga 814981 cacgttcgcc aaagcgcgtg acgtgcaggc tgcagatcct gacacactgc cgaatacgta 815041 tttgcaatat tatttgttcc cagatgatat ggtgaaaaaa tcaaatccga atcatacgcg 815101 ggcgaatgaa gtcatggaag ggcgcgaagc ttttattttc agccaatgtg acatgatcac 815161 acgtgaacag tcctcggaaa acagcgaaat taaaatcgat gaccacgcat cgtatatcgt 815221 tgatcttgcc cgggcgattg cctacaacac aggtgaaaga atgctgttga ttgttgaaaa 815281 taacggtgca attgcgaact ttgacccgac tgcgatggtt gaggtgccat gcatcgtcgg 815341 ctcaaatgga cctgaaccga ttaccgttgg caccattccg caattccaga aagggctcat 815401 ggagcagcag gtatccgttg agaagctgac tgttgaagcg tgggcagaga aatcgttcca 815461 aaagctgtgg caggcgctga tcctgtcaaa aacagtgccg aacgcgcgtg tggcaagact 815521 cattcttgag gatttagtgg aggccaacaa agacttctgg cctgagcttg atcaaagccc 815581 aacccgcata tcataaatga aattccccca ttttcgaatc tgtaattgta tataatagaa 815641 agaaaatggg gggatctgat atgcagctcg aagaactgat caatcagcac tacagcaaat 815701 tgaatgacaa cgattttcat attttaaaat atatattgaa tcataagcac acatgctatc 815761 accttggaat cgacgcgctg gccaaagctt gcagtgtatc gcgttcctca attttacggc 815821 ttgcccaaaa gctcggtttc agcggttaca gtgaatttcg cgtcttttta aagtgggaag 815881 atcagccgga agaaggcgag agtatgagtt ttgaaaagct gcttgatgat attgaagcaa 815941 atttgaagtt tttacggaca aaggacatga cggacatgtg ccagctgatt gatgcagctg 816001 accgcatttt cgtctacggt tctggaaatg cgcaaaagat atgcgcccgc gacctgcaaa 816061 gaatgtttat tccgcgccat cgctatctta ttttgattga agacacaaat gaatttaatt 816121 tgatgcgcga tgattttaaa gtgaacgatc tgtttatcat catttctctt tccggagaaa 816181 caccggagct gattcctcag gcaagaatgc tttctgcaaa gggtattccc tttatttcca 816241 ttacgaattt aaaaaacaat gtcctcgccc agctgactcc gcataatctt tatgcgacaa 816301 gcaaacctgt gacattaagc gatagaacgg aaattgtcgc ttttgcaccg ttttttctcg 816361 ttggcgaagc attgttccgc gcatatgttg attacaaaga ggcagaaaaa aatgacaatg 816421 agtagcaggg ggttctggta tgatgcaaaa aattcagcgc tttggaagcg cgatgtttgt 816481 gcctgtttta ttattcgcgt tcgccggcat tatcgtcggt atcagcacgc tctttaaaaa 816541 taaaaccctc atgggaccgc tcgccgatcc tgacggtttt tggtatcagt gctggtatat 816601 cattgagcag ggcggctgga ctgtttttaa ccaaatgccg ctcttattcg ccattggcat 816661 cccggttgct ttggcgaaga aagctcaggc acgcgcctgt ttggaagcgc ttactgtcta 816721 cctgacattc aactattttg tcagcgcgat attgacggta tggggaggag catttggcgt 816781 cgacatgaat caagaggtcg gcggaacgag cgggttaacg atgattgcgg gcataaaaac 816841 gctcgatacc aacatcatcg gagccatctt tatttcttcg attgtcgtct ttttgcataa 816901 tcgctatttt gataaaaaac tgcccgattt tctcggcatc tttcaaggct caacatatat 816961 cgtgatgatt tccttcttta ttatgatccc aattgcgttg gctgtgtctt atatttggcc 817021 gatggttcaa tcgggaatcg gctcgcttca aagcttcctg gttgcttctg gggcggtggg 817081 cgtttggata tacacgtttt tggaacggat tttaattccg accggccttc atcactttat 817141 ttacacgccg tttatttatg gcccggctgt agcggaaggc gggatcgtca cgtattgggc 817201 acagcatctc ggcgaatatt cgcaaagcgc caaaccgctg aaggagctct ttccgcaagg 817261 cggattcgcg cttcacggca actcgaaaat cttcggtatt ccgggtatcg ccctggcttt 817321 ttatgtgaca gccaaaaagg aaaagaaaaa actcgtcgca gggctgctga ttcctgtcac 817381 actgacagcg attgtcgccg gtattacaga gccgattgag tttacgttct tattcatttc 817441 acctttctta tttgcggttc acgccgtgct tgccgccaca atgtcgacag ttatgtatat 817501 ggccggcgtc gtcggaaata tgggaggcgg actgattgag gcggtaacct tgaactggat 817561 tccgctcttt ggcagccacg gtatgacata tgtgtatcaa attttgatcg ggctctcgtt 817621 tacagcaatt tattttttcg tcttcagatt tttaatcctc aaattcaata tcgctacacc 817681 aggacgggaa aaggatgaac agcaggaaac aaagctatat tcgaaaaagg aatacagaga 817741 acgaaaaaac aaggatgaaa cggcctccgc tgctgaaacg gctgatgaca ccgcttttct 817801 gtatattgaa gcgctgggcg gaaaagacaa catcactgaa gtcacaaact gcgccacccg 817861 cctcagagtc agtgtcaagg atgaaacaaa ggttgaaccc gacagcgtat tccgcgcgct 817921 tggcgcacac ggcgttgtca ggaacgggaa ggcgtttcag gtaattatcg gattaagcgt 817981 gccgcagatg cgggagcgtg tggaaaaaat attgaatcaa taaagactgc cctccttttc 818041 gggagggttt tcgtttgccg tcaaaaagac cgccatagta aagtaaagaa agagacaatc 818101 gagtaaaaag gggtttggag gcttttacat gcaaaaggct ttgtcgtttt taaaaccata 818161 ttcattgctg gcgggaattg ctctgattct tatgctgacg gagcttgcag ttgaactgat 818221 gcagccttta ttgattgcaa aaatcatcga cgatgggata ttgaagcaag atctgcggca 818281 tgtatggata tggggcacgg tcatgatcgg gctgaccgtg ttatcctttg cggcggggat 818341 gctgaattcc ttttatgccg cccatgtcag ccaaagcttt tcctatgata cgagaaaagg 818401 gctttttcaa aaaatccagt ccttctccta ttccacattt ggacagtttt cgtcctcttc 818461 ttatattaca aggctgacaa acgacgtcac acaggttcaa aatatgattt ttatgagttt 818521 gcggtttatg ctgcgggctc ccttaatgat tgcaggcggc attgtgctgt cgcttgccgt 818581 taatgtgaaa ctcgggtttt ttctgcttgt gaccattccg atcctgatct tgtttttgct 818641 atgggtatta aggaaaggcg gggcactgtt ccgctcagtg cagaaaaggc tggatcaagt 818701 gaacaccatc atgcaggaaa atttaattgc aatcaagctg atcaaagcgc tgcttcgcgg 818761 cagccacgaa gtcaaacgat ttatcaaagc caacacaagg ctgatggaaa aaacggtttc 818821 ggcctttcag cttgtggaat tcacgatgcc tgtactgatg ctgctgatga atctctgcat 818881 ccttttgatt ttgtgggcgg ggtcctacag tattacgagc ggaagcactc aggttggcga 818941 tgttgttgcg ataattaact acgcaacacg aattacaggc gcgctttcga tgtttccgtt 819001 tttgattatg attttcaccc gggcgaaggc ttcaggggat agaatcggtg aggtgcttga 819061 aacagaaggc gacgagcggg aggaaggcac catatctgat cgtttgtcag gacggattga 819121 gtttcagcat gtatcctttc gctatcctga aatggacaga gaagcgctca ggaatgtctc 819181 attttccgca aagccaagag aaacgatcgc gattctcggt gcgacgggct cgggcaagtc 819241 cacgcttttt cagctcattc cgcggcttta tcagccggat tcaggccgca tttacataga 819301 tgaaaagccg gttcaagata ttccggctga agggctgcgc aggcaaattg gatatgtacc 819361 gcaggaagtc ctcttgtttt ccggcacaat caaagaaaac atcgcttggg gcaaagaaaa 819421 tgcttcacta gatgaaataa tggatgcggc aaaacttgcg caaattcatg aaacgatttt 819481 aaagctccca aatggatatg acactgtttt ggggcaaaga ggcgtcaacc tgtccggcgg 819541 ccaaaagcag cggatttcca ttgcgcgggc gctgattcga aaaccggcta tccttctatt 819601 agatgacagc acaagcgcgc ttgatctgca aacggaggcg aagctgcttg aagcaatcag 819661 cacataccat tgcacaactt tgatcattac acaaaaaata accacggcga tgaaagctga 819721 tcagattttg ctgcttgagg acggcgaact gattgaaaaa ggcactcaca gtgagctgct 819781 ttctgaatct cagttataca agcgcattta cgagtcacaa ttcggaaggg aggggagcga 819841 gtcatgctaa aagacatccg caagcctttc caatatccca aactgccaat tgacaaaaaa 819901 gaaggcgcga aaaagcgggc gaaagcaaag gatacaaagg gcacactgag acgaatctgg 819961 tcttacttgg ctgaaagaaa aggactgctc atacttgtca tgctaatggt tgtcatcagc 820021 gccatattcg gactccttgg tccctttgtg atcggaaagg ccatcgacca ttttatcgtc 820081 gggaaaacgg tcagcggctt gattcctgtt ttgcttcttc tgctcgctat ctatatcatt 820141 cagtccctgt cgctttggtt tcaaaactat tggatgatta cgatctcgca gggcacggtt 820201 ttcagaatga gaagcgaatt gttcacccat ctgcatgagc tgccgattcc attttttgat 820261 aaacagcggc acggcgagct gatgagccgg gtgacgaatg acatcgaaaa tgtcagttct 820321 accttaaaca cgtcagtcat tcaaattttg tcaagtgtga tcacctttgt cgggacgatt 820381 gcggtgatgc tgtacatgag cccgctcctt actttgatta cgctgaccat tattccggtg 820441 atggcagcga gcctgaaatg gatcaccaac cgaacgggaa agctgtttaa agaacagcag 820501 aaaaaccttg gtgatctgaa tgggtatatt gaggaatctg tttcaggcgc aaaggtcatc 820561 aaagcatatt cacgtgagaa gcagattact gctgaattcc tcgaaaaaaa cgctgcactc 820621 aagacgtcgg gcttttgggc gcagacgatt tccgggttta ttccgaaggt catgaactct 820681 ttgaataact taagctttac aatgattgcg gcaatcggcg gtttgtttgc gctgaaaggc 820741 tggatctcga tcggctccat cgttgtcttt gccgagtatt caagacaatt tacacgccct 820801 ttaaacgatc tggccaacca gtttaatacg atgctgtccg caatcgccgg cgctgaacgg 820861 gtgtttgacg tgcttgatga aaaagaagag cgcgaggatg aaaagaacgc cgtgcatcag 820921 cccatccaaa caggcagcat tgaattccgg gatgtgtcct tcggttacga taaagggcag 820981 cagacactga agcatttaca gtttaccgtg cctgcggggc agtccatcgc gtttgtagga 821041 ccgacggggg cggggaagac aaccgtcact aaccttctcg cccgttttta cgagcctaac 821101 gatggaaaaa ttttaatcga tggtacagat attaaaaccc ttactagagc aagcctaaga 821161 aaaaacatgg ggtttgttct tcaggattct ttcttatttc agggaacgat cagagaaaac 821221 attcgctacg gcaggcttga tgcttctgat caggaagtcg aagccgctgc aaaaacagcg 821281 aatgcccata gttttattga aaggctgcca aaagggtatg acaccgtact gacgcaaaac 821341 ggttcgggca tcagtcaagg gcagaagcag ttgatttcta tagcgagggc ggtgcttgcc 821401 gatccggttc ttctcatttt ggatgaagcg acaagcaaca ttgataccgt tacagaagtc 821461 aacattcaag aagcgctcgc ccgtttaatg gaaggaagaa caagcgtcat cattgcccac 821521 aggctgaaca ccattcaaag agcggaccag attgtggtgc taaaaaacgg tgaaatgatt 821581 gaaaaaggca gccatgacga gctgattcgg caaaaaggat tttacagtga cttatatgaa 821641 agccaatttg agaaatagac ctttgtcctg cacagaggtc tttttttgtt acagttttat 821701 agtactttta tttcattttc gtaaaatgta acaaaattac ttgacgtaaa caagttatgt 821761 atatatacta gcttacatta agtaagtgat aacatttatc aaggaggata aaatgaataa 821821 atcatttgaa attggcacat tacttttaag agttattaca ggtattatct tttttgttca 821881 cggtttatca aagtttcagg gaatggaggg caccatccaa tttttcggca gcataggcct 821941 tccaagcttt atggcgtatg tcatcgcagc gattgaactg attggcggag tgcttgtctt 822001 cttcggattg gctacacgta ttgtcggtgt actgttcgct cttacactga tcggcgccat 822061 catcactgtt aagctgaaag cgccattcat gggcaatgca gaatttgatt accttctgct 822121 tttgacatcc attcacctgg cgcttactgg aagtcgattc ctggcgctgg acccatttgt 822181 gtttaaagga aaaaagaacg gaaacgtttc agcataagaa aagaggcatg cagcatgacc 822241 agcattcatg aggatacaca cattggctat gccaaactca caattcgcag tctggagcgt 822301 tcgcttcagt tctactgtaa cgtcatcggt tttcaagtct taaaaaagac ggaccgccaa 822361 gcggaattaa cggctgacgg gaaacgcgta ctgcttattc ttgaagaaaa tccgagcgct 822421 gtcgtcttgc ctgaacggtc tgtgacaggc ctttatcact ttgcgattct tcttccggac 822481 aggaaagaac ttgggatcgc gctcgcccgc ctgattgaac acggcattgc tatcggacat 822541 ggagaccatg ctgtcagcga agcgctctac ctgtctgatc ctgacggaaa cggcattgaa 822601 atgtacgctg accgcccccg cagcacgtgg cagcgtgatc gggaaggaaa ctacgtcatg 822661 acgacaaccg ctgttgacat tgagggcctt ctggaagagg caggagatga gcggaaaaca 822721 tcgcttccga acgatacaat catcggacac attcatctgc atgtcagtga tttgaaagaa 822781 gcaaaggcgt tttatacaga tgtactgggc tttgacattg tcggaaacta tgcgggcatg 822841 tccgccctct tcgtttcagc cggggggtac caccatcata tcggcttaaa catttgggcg 822901 ggaagaaatg cgccgcctaa accgacaaat gccagcggac tagattatta tactgttgtc 822961 ctgccccacc aagaggagct ggatttggtg gcaaaccgag tcaaacatgc cgggtattcg 823021 attgaagaga cggaaaacag ctttcgtgtg aaagaccctg tttccggcgc ctatattaca 823081 tttgtgattt aactgcaatc cccttgccga aataacggca gggggatttt ttatttttgt 823141 ccgccttgtt atgatgagag aaccaacttg ttaggaggcg tttacatgga actcaaccac 823201 cttgtgacgg gcaaaatagc attaaatcaa tatgtgcatc gcttagagca aaaggatgtt 823261 tcattttacg tccactactg gggagcgatg acgaaccact ataacacact gcttcataag 823321 cattcctttt atgaaatttg ttacgtggta agaggtgaag gatattacct tgaaggcgat 823381 cgtacatatc cgcttcgtga acagacgatt tttttgtcaa agccggagca tttgcaccaa 823441 atcaaaagtg aaacagggct gttccttttt tacgtcgctt tcgagctgag cgaggatcag 823501 tcaagcgccg aatggatcaa agtgatggaa gaagtgaaac aaagcccctt tatcacaatg 823561 caattgaaag atggcgaacc gccgggcctg ctttggaaaa cgttaatgct gcaagcagcg 823621 caacctgtca atgcttttga caaagagatc ctatctcatt tgtcgcatgc attgatcctg 823681 tcattaatcc aaacctttct cccgtacgcc caacgcccga aacaaaagca gcccattcac 823741 acatcttctg ctttgctgac agaggtgaaa ctgcacataa aagacaatct gtcacagccg 823801 ttaaagctga cggatgtcgc tagccacttt catatctcag ggaggcattt atcacgttta 823861 tttgcagcag aactgggcgt cagctactca gaatttgtcc aaaatgaaaa aataaacaaa 823921 gctgccgaac tgctgaaatc aacgaatttg tcgattaaag aaatagcgga agaaatcggt 823981 ttctcagtac attatttcac tcgcgtcttt tccgctaaaa tcggcagctc tccagggctt 824041 ttccgctccc tttataaaga ctcaaaaatg accgcatttc aaatcaataa accttttcaa 824101 aaaatcgaac aggccaagcc gcacgaataa gatgtcctga aatgacaaaa caatgtcttc 824161 atatgataaa gacgcgagaa atctcgttgt cttataatct ttttagaaag cggttacaac 824221 aaggggtatt gctgaaggag ggatgcattg gcttatgctt ggtgtcgggt gctctgccat 824281 tcttgaaaga aggggaagaa agccgtgagt acaaaaaaga aagaggctgt aataggaaaa 824341 gaaagcttag ctcataaagg gcttttacga acgattacat tggtatctac attcggcggc 824401 ctgttgttcg gttatgatac gggtgtcatt aatggggcac ttccttttat ggcaactgca 824461 ggtcagctga atcttacacc tgttacagaa ggactggttg cgagttccct gcttctcggg 824521 gcagccttcg gggcgatgtt tggaggacgt ctgtccgatc ggcacggccg ccgaaaaacg 824581 atcctttatt tagccttact cttcatcgca gccacacttg gctgtacctt ttcaccaaac 824641 gcgtccgtga tgattgcctt tcgttttctg cttggactgg cggttggctg cgcttctgta 824701 acggttccaa cctttttagc ggaaatttcg ccggcagaac gcaggggacg aatcgtgaca 824761 caaaatgaac tgatgatcgt aattggccag cttctggcat acacctttaa cgccattatt 824821 ggcagcacaa tgggggagag cgcaaatgta tggcggtata tgctggtcat cgcgacactt 824881 ccggctgttg tgttatggtt cggaatgctc atcgtgcctg aaagcccgcg ctggctggca 824941 gctaaaggca gaatgggtga cgccctgcgg gtgcttcggc aaatccgtga agacagtcag 825001 gcacagcagg aaataaaaga aatcaaacat gcgattgagg gcacagcaaa aaaggccggc 825061 tttcatgatt ttcaagagcc gtggataagg cgcattctat tcattgggat tggaatcgcc 825121 atcgtacagc aaattaccgg tgtcaattcg attatgtact atgggacaga aattctgaga 825181 gaagccggtt ttcaaacaga agctgcatta atcggcaata ttgcaaacgg tgttatttca 825241 gttattgcgg tcatttttgg gatatggctt ctcggcaaag tccgtcgccg gcccatgctg 825301 atcatcggac agattggcac gatgacagcc cttctgctga tcgggatttt atccattgtc 825361 cttgaaggaa cacccgccct gccgtatgtt gtgctgagtt tgaccatttt gtttcttgcg 825421 tttcagcaga ctgccatttc tacggtgacg tggctgatgc tctcggaaat ctttcctatg 825481 catgtgcggg ggcttggcat ggggatcagc accttctgct tgtggacagc taactttctc 825541 attggattca cctttcccat tttgctcaat catattggga tgtcggcgac attttttatc 825601 tttgtcgcta tgaatatcct agcgattcta tttgtgaaaa aatatgtgcc tgagacaaaa 825661 gggcggtcac ttgaacagct tgagcattcc tttcgccagt atggccgccg cgctgatcag 825721 gaaatccaaa atcaaacaac tcacttatcg taacctgaga taccaggagg aatctatcaa 825781 tgaaactatc ttatgtaaca gacagcctag ggcatttgcc ttttgaagac atgctcaatt 825841 ttgccgcaaa gcttgggatc gatacacttg aaatgacaac cgggggctgg tcgccggcac 825901 ctcacttgaa tcttgatgaa ttgctgcaaa gcagcgaaaa aagaaaagaa ttttcacaag 825961 cgctggaaaa gcggaacatg acactttgcg cattaaactg ctcggggaac cctttagatc 826021 cgggtgaatt gggcaaatcg cacagagaca taactgacaa aacgatggag ctggctggat 826081 tattaggcgt caaaaaagtg atcatgatga gcggtttgcc agccggcggc ccggacgaca 826141 aagtgccgaa ctggatcaca tacacagtaa gctggcctcc cgttttaaaa gatatcctca 826201 actatcaatg ggaagacgtt gcgatcccat attggaagaa gcttgtcaaa aaagcggagg 826261 cctgcggcgt ggggaaaata gcgcttgaga acttcagctc tcaattagtc tataatcctg 826321 agactctctt tcggctcaga aatgcagtcg gcccgatggt cggtttgaat cttgacccga 826381 gccatttgtt atggatgggc gcagacccga tcatcgcagc aagggagctc ggctcagcca 826441 ttcaccatgt ccatgggaaa gatgtcagaa ttgaaagata tttatcggcg gtcaacggac 826501 ttttagaaac aaaagaagtg acagatcctg caaaccgggc gtggaattac gtagctgtcg 826561 gctgtggaca ggatttacag tggtggaagg aatttttttc agttgtaaaa atgatgggat 826621 atgaaggtga ggtttcttta gaaatggagg atctgacgat gtcacctgaa gcgggcatcc 826681 gtacttctgt agaagcttta aaacaaacca tcagccaata ggaggttttc atgatgctaa 826741 atggagaaag aatcatctct aagccgcttc gctgggcaat ggtaggcggc gggcggctca 826801 gccaggttgg atataaacat cgtattggag cgctgagaga caatactgct tttcaattaa 826861 ctgctggcgc ttttgatatc gatgccgaaa gaggaaaaga tttcggggtg aaccttggag 826921 tggatgcgga acgctgttat cccaactatc aaaccatgtt tgccgaggaa gcgaaaagac 826981 aggatggcat agaggtagta tcgattgcca ctccgaacgg cactcattat gagatttgta 827041 aggcggcgct tgaagcagga gtgcatgtca tctgtgaaaa accgctgttc ttcacttcag 827101 cagaggggca ggaaatcaaa gcgctcgcag agaaaaaagg gaaaattgtc ggcgtgacgt 827161 acggtttttc aggcaatcaa atgcttcttc aaatgcgtgc gatgattgaa caaggaatga 827221 tcggcgatat tcgcgtggtt gacttgcagt acacacacgg tttttgtgca acagatgaag 827281 gtgaaaagat aagcgctgca cagaaatggc gtgtcgaccc tgcgatcgcc gggccaagct 827341 ttgtgctggg cgatttatct acccacacgt attatatgtc acagcttatt atgccaaaga 827401 tgaaaattaa ggagctgctg tgtgaccgac agagcttcgt cggcagccgc gcaccgctag 827461 aggataatgc ccatgtgctg atgcattatg aaaatggagc ggtcggaacg atgtggacat 827521 cgtcaatcaa tgccggatgt atggatggcc atagaatccg gattgtcggc tcaaaggcaa 827581 gcattgagtg gtgggacagc aagccaaatg aactgacgta tgaagtgcag ggagagccgg 827641 gccagacact cgttcgcggc atgccgtatt tagatgatgt ttgcaacgcc gatgaacgac 827701 tgggcgcctt acacagcgaa gggctgtccg aagcatgggc caatatttat cttaaatttg 827761 ccattgcgat agacgccaaa aaccgtgaag atgaagaaat cttgaacaac ttggtttatc 827821 ctgacattga tgcagggatc gagggcattc gctggattga gaactgcgtg cgctcggcaa 827881 accaagggtc agtttgggtt gaatttaaat aaatgaggga atgcgccgca tatgacataa 827941 agttcatatg cggtttttat tttccagaaa ctcctgtcaa aaatgccctg aggcaggtat 828001 gataagaagg gaattgggta tcgggagtga tgagcgtgaa agctcttttt tttacgagaa 828061 tgttcacctt gatggtgagc tgtttaatgt atctgtccat tgtgaaagag gataactggt 828121 ttggatatgt atttatagca gcaggtgctg ccatgtatgc agccaatcat gttttgctga 828181 caaaagagac aaatgccatc tggttctgcc tgattgatat tgcaatcggc ttttcgttcg 828241 gatttatctt tcccggcaca ggtttgttca ttattatgct ttgtccggtt gcggtcgcct 828301 tttttctgcg ggggtttcct aaaagaacag catggtctgt cttatgtctt tcctctattt 828361 tatttttgac cgtcctcatc cgtacatatg cgatgttcgg caatgaattt gtcattgatc 828421 atttgactag catgacattc gttgtcttct gcggtgtcgt gggcaaatta atccgcaagc 828481 tgttggatgc gcaggatacg gcaaaacagc agtttcagga actgacggag tcccatctgg 828541 cgctgtctgc tgcacatcag gagctccatt tatatgcgaa gcaggttgaa gagctgactg 828601 ccatttacga gcggaacaga atggcgcgtg aaatccatga tacagtgggg cataaaatga 828661 cggcccttct cgtccagctg cagcttttgc gtgaatggca aaaaagagac agccaaaaag 828721 cggatgagac agtaggtgtc tgtgaaacac ttgcccgtga agcgcttgat gatgtccgct 828781 tatcagtacg cactctgcaa actgaaaacg atccttcgct aatcgaatcg ctgaaacagc 828841 tgacagagga cttttgcaaa aatgcaggag tcacaacaga atttgcggtc agcggtgatc 828901 ctgcaatcat cccgctgtct ctccatccga ccctgatcag aacggtgcag gaagcactga 828961 ccaatgccaa acggcacggc ggcgccgcag cctgttcgat acagcttgcc tgcacaacgg 829021 acagcatcag ccttgtcatt aaggatgacg gcaaaggcaa tcctgaggca gcacttggtt 829081 ttggtctctt gaatatgaaa aagcgggcag cggagcatgg cggaatgatc cgctttgaaa 829141 gcgaacggga tcaaggattt actgtaaatg cagaattttc acttgccaat aaaaaatgga 829201 gcttcgggcc cgtgcagcaa aaggagagtt tatcatgatt aagatcatca ttaccgacga 829261 tcaggatatc gtcagagaag ggctggcatc cctgctccag ctccgagaag agctcgatgt 829321 gatcgcaacg gcgcgaaacg gacaggaagc cttcgaaaag gcgaaagagc tggagccgga 829381 tatcgtgtta atggacatcc gcatgccggt ttccaacggg gtggagggaa caaaattaat 829441 cacaagctcg ctgccaagcg taaaggtttt gatgctgaca acctttaagg attcagcgct 829501 gattgctgaa gcgcttgaag agggagcaag cgggtatctg ctgaaggata tgtctgcaga 829561 tacgattgta aaagcagtga tgactgttca ttctggcgga atggtgcttc cgccggaatt 829621 gactgcccaa atgctgaatg aatggaagcg tgaaaaacag ctgaaaggaa taaatgagat 829681 agaaaaacct aacgagctgc tcgacctgac cgagcgcgaa atcgaagttc tggctgagct 829741 gggatacggg ctgaataaca aagaaattgc cgaaaagctt tacattacag aaggcacagt 829801 caaaaaccac gtttcaaata ttatcagcaa gctggctgtc agggacagaa cccaagccgc 829861 catttactcg gtcagatatg gtgtatctgt cttttgacat atgacgtttt gcatatacgc 829921 ttctctgaaa aggcctttta caggcctttt tttcatgccc tatgttctat ctgccgctac 829981 atgccgcacg cctttctttc ttctacaatg gcaatggatc aaaaaaagga gtgagacgac 830041 gtgctgcaag cagaaaacat caaaaaggca tacggaaaaa aaacaatcgt gaaaggcatt 830101 tctttttccc tcaaaaaggg ggagtcgttc ggtctgctcg ggcctaacgg tgcggggaaa 830161 tccacaacca tctcgatgat ttccggcctt gtgccgcatg acagcgggaa catcacggtg 830221 ggcggctatg ttatcggaaa agaaacggcc aaagcgaaac aaaaaatcgg cattgttccg 830281 caggaaattg cattatatcc gacgctgacg gctcatgaga atcttatgtt ttgggggaaa 830341 atgtacggac ttacgcacgg tgaggccaaa aaaagagcgg ctgaggtcct tgaatatgtc 830401 ggtctgactg agcgggctaa agataagatt gaaacatttt ccggggggat gaaacgaaga 830461 atcaacatcg gtgcggcttt aatgcataag cccgagctgc tgattatgga tgaaccgact 830521 gtcggtattg accctcaatc gagaaatcac attttagaaa cggtcaaaca gctcaacgaa 830581 acgggcatga cggtgatcta tacgagtcat tacatggaag aagttgagtt tttatgcgac 830641 cggatcggga taattgatca gggggaaatg attgcgattg gcacaaaaac tgatttgtgc 830701 agccgccttg ggggcgatac catcattcag ctcacggtca gcgggatcaa tgaagcgttt 830761 cttgtggcga tccgatctct ggcccatgtg aatgatgtaa cagtacatga attagagctc 830821 aaaattgaca tttctgcggc tcatcatgag aaagtcgtca caagcctgct tgctgaagcc 830881 actgctcatc atataaacct gctgtctctt caggtgcagg aaccgaatct ggagcgcctg 830941 tttctgaatc tgaccggccg cacgttgcgg gattgaggag ggacggcaat gaaaaaaagc 831001 atatggatcg catggaaaga tgtgaaaatc agaatcacgg acagaaaagg gtttatgatg 831061 cttatcctaa tgccgctcat cctaacctgt attttaggcg cagcgctcgg atcagttgtt 831121 gacggaggca gccggattga tgatatcaaa gtcggctaca ttcaatcaga ccagtcagat 831181 acagcaaaca tgtttacaaa agatgttctc aaaaaaatga agtcgataaa ggtcacaaaa 831241 gtcggcagca aagacaagat gaaaaaactg attgatgaaa agaaaatcga tgtaggcatc 831301 gttatcccga accattggga agccggcaaa acctcagctg ttgttaatgc cgctcctgat 831361 caaacattga aaagttccat cattgaaaca gctgcaagct catttataga gcaatataaa 831421 gcggtaaagg aagccgcgtc aggctcaatg gactacatca gtaaaacgga agctgtaaag 831481 caaggaaaac ttgaccctgc acagtttgca gaaaagctgg caaagacgct agaaaaagaa 831541 acaggtgaca agcttactat tgcggaaaaa tctgtcggca gcaaagccgt taccagtttt 831601 caatactatt cggcggcaat gctttgcatg tttatgctgt ttcatatcac agtcggggcg 831661 aaatcatttt tacaggaaaa ggatacggag acgcttgcca gaatgctgat gacgcctgcg 831721 caaaaatccg tcattctctt cggaaaatgg cttgggacgt atctgtttgc catcatacaa 831781 tttttcatat ttctgatcgt cacaatcaac gtatttggtg tggactgggg cggtaatctg 831841 ctgttagtga gtgtactcgg gctttcttac gccgcagctg tatctggtat ttcaatgctg 831901 cttgcgtcgt gcatcagcga tatgaaaact gcagatgcga taggcggctt cggcattcaa 831961 ttgcttgcgg ttctcggcgg gtccatgctg ccgctgtacc aatttccgga cgtcttgcag 832021 tctgtatcca aagcggtgcc aaatcgctgg gcgcttgacg gctttctttc tttaatggaa 832081 gggggaggct gggctgacct tcaaaagcct gtgcttcttt ttgcggcgat cggcttttgt 832141 tcacttgtaa ttggtatcag acggcttcat acaagataag gaggtacaaa aggtgaaaaa 832201 aattctagcc atttgcggca ttgagctttc tctcattttt aagaagccac agaactattt 832261 gatcatgttt gctgccccgc ttttgcttac ctttgtattt gggagtatgc tcagcggcaa 832321 tgatgataag gtgcggcttg caatcgttga tcaggacgat acgattctct cacagcatta 832381 tattcggcag ctgaaggcac acgatgatat gtatgtattc gaaaacatgt ctgaaagcaa 832441 agcgtcagaa aagctgaaac aaaagaaaat tgccgggatc atcgtcattt cccgctcgtt 832501 ccagacacag ctggaaaaag gcaaacatcc tgagctgatt ttccgtcacg gccctgagct 832561 gtcggaagcg ccgatggtca aacaatatgc agaaagcgca ttggcaacgc tcaatattca 832621 ggtgaccgcg gcaaaaacgg catctcagac agcgggagag aactggaagg cggcgtataa 832681 aacggttttc gccaaaaaac atgaagatat agttccggct gtaacacgac agacgctcag 832741 tgataaaaaa gagggtgcgg aagcaagtga cacagcctcc agagcagcag ggttttccat 832801 cctgtttgtc atgctgacca tgatgggagc ggctggaacc attttagaag caagaaaaaa 832861 cggcgtatgg tccagattgc ttacagcctc tgtcagccga gccgaaatcg gtgctgggta 832921 tgtgctgtcc ttctttgtca ttggctggat tcaatttgga atattgcttc tttccaccca 832981 ttggctgttt ggcatcaact gggggaatcc ggctgcagtt attgtattag tgtcactttt 833041 tctattgacc gttgtcggca ttggattgat gattgcggcc aacgtcagaa cgccagaaca 833101 gcagcttgcg ttcggcaact tgtttgtcat cgcaacatgt atggtgagcg ggatgtattg 833161 gccgatcgac attgaaccga aatttatgca atccatcgct gaatttcttc cgcaaaagtg 833221 ggcgatgagc gggttgacag agattatcgc taacggtgcc cgcgtcacag atattctcgg 833281 aatctgcggc attttgcttg catttgctgc gatcactttc gcagcggggc tgaaagcgct 833341 ccgagcctaa aaaacatctg ccgtttaggc agatgttttt ttgcatgtgg gtacattcgt 833401 atgggtgcag cctgaactgc ggttaatcct tatctatcat agctaaaatt gattccagcc 833461 aagaaacgta atttttctcc cgctccagcg ctttcgttag cacaagatag tggccgaagt 833521 ccggtgaaga aaatgacatc ggctctgctg aagccataag cttttcatag cttccctgta 833581 agtcagaaag cttggcctgg cgtttttgca gctggtcttt gaacaaatca gaagcctcct 833641 ggcgcgatag acaagaaatg aaataagcct tcagcataaa ttcatccttc accgtctcgg 833701 gtatcggctg gtggcggatc agccagtcat gcagctcctg ctttccgctg tctgtcaggg 833761 tgtacatctt tttctccagc tttgtgccct gaatcgttgt ccggaacgtg ataaatcctt 833821 catccgtcag ctttttgagc tcagggtaaa tctggctgtg cttggcgctc caaaactggc 833881 cgagctcctc tttaaaataa ctcgtaatat cgtatccact caattcgcct tttcgcaaaa 833941 gccctaatat ggcgtatttt aatactctca tgctatcctc cgtgtctggc tgtttcgcaa 834001 aacagatgag ccggtgctca actgtgattc taactgccta ttccccttat tatagaaaag 834061 ggaggaaggg aacacaaccg ggctctttgg aaatgaagat aaaaggtttg tcagaaggta 834121 tccgatttat ctccgtcaat ataaaagaga tttaaattta attttcagaa aaaatagtaa 834181 cgatattgat tttttatata taataggaaa ttggtggtat gaaaattttt tgggggaata 834241 aacgtgaaaa aagtacttat ggcattcatt atttgtttat cgctgattct atctgtttta 834301 gccgctccgc cgtctggcgc aaaagctgag tcagtacata atcctgtcgt tcttgttcat 834361 ggaataagtg gtgcatcata caactttttc gctattaaaa actacttaat ttctcaaggc 834421 tggcaaagca acaaactgta cgcaattgat ttttatgata aaacaggaaa caacctaaat 834481 aacggcccgc agcttgcttc atatgttgac cgtgttttaa aagagactgg ggcaaaaaaa 834541 gtagatattg tggctcatag tatgggaggc gccaatacgc tgtactatat taaatattta 834601 ggcgggggca ataagattca aaatgtcgta acgcttggag gggctaatgg tttagtgtca 834661 tcaaccgcgc tgccgggcac agaccctaat caaaagatcc tctatacatc tatttacagt 834721 ctcaatgatc aaattgtcat caatagcttg tctcggttac aaggagcgcg aaacatccag 834781 ctttatggca tcggtcatat tggcttgctt tctaatagcc aagtgaacgg ctatatcaaa 834841 gaagggctga atggcggagg cctcaataca aattaatatc ttcaaaaaac aacctgctgt 834901 ctccgttaca gtgggttttt tcgtctgaga aagccatagg gtcttatgac cttagtctat 834961 catgcatacg tcaatttatg acatcaggca ctttttcaaa tagagcggac atgttaaggt 835021 acaaccatcg atttctatca atttgaaata aaaggagcgc tgttatgcaa attaaagaaa 835081 tttttatgat ccgctgcatt tcgtgcttaa gtgtcgtctt gctccatatc atttcaatgg 835141 tcctgatgct tcaggcagaa gctcttgcag atatttctca cactgttgat tctttccgca 835201 cactcctgat gttcagcacg cccgctttta ttttcatctc tgaattttta ctggcccgtt 835261 cttatcctga tggggtgcct gacggttttt taaagaagcg gggaaaagtg atttttgttc 835321 cttttttatt tatcgcagcc atcgatgcgc tgctgatgac cagtgcgatg gggggagagg 835381 taacctttct cgcgtttgtg caaaaatatc tggcgaacgt attcttagga aactttatcg 835441 gatacttcat tctcgtcatc tttcaatttt acatgctgca tatgatgttt catgagtatt 835501 tgaaaaaagc atcgccgaaa tgggtgctgt ctatctcatt tgtggtgaca gccgcttatt 835561 taggctattt ctccgcagcc agcccggctc ctgcttctga agagggaggg gcatttccgt 835621 tcttctgggt tccgttcgca ggctggcttt tctacttttg tctagcctac tattgcggaa 835681 aagaatacaa gcgtttttta gcgctgctga accaataccg ctgggtggtg tacggcgccg 835741 caattgcttc tggggcgctg gttgtcactg tttcttatgt cggtgaaatc ggcatgatca 835801 gctcgaagcg gcctgatatc atgctgtatt caacaagcat gattttcctg tgttttcatt 835861 tgttttccaa aatgaagcat gtgccgaaaa tcatgatgtt tatcagcaac tattcctttt 835921 cgatttatct gcttcatgcc tattttatga ttataggcta cgtgttgctt ttgaatatgc 835981 ccgaaattcc tgccgtaccg gctgttctcc tgttgtttgc cgtgtgcaca gccggcccga 836041 ttatgacctc atgggcgctg aataagttca aatacgggta tttatttgtg gggaaaattt 836101 atcagccaaa acagaagaag gtaacagtcg aagtgcgtga tcacgcaggg tgaaaaacaa 836161 gcggcaggag ggctcctgcc gcgtttcttt acttctcatc cgcttgcaga actgttttta 836221 aatatagttt tgcagactca gcaagtccag atacatcagc cttttcttca tcgaaataca 836281 gggcgttttg aatgatgccg tcattcatat tgaggaaaaa cttggcgata gtcgcaagag 836341 gctgaaccgg ctgaaactct ccctgatcga tccctttttg caatagcctt gaaaaccttt 836401 ccacaaaaag atcatacctt ttctccaaat actgccgccg ttcttcattg cgccaagctg 836461 tcactaaata ttcaaattgc accggcgcca gcgtatctgc tacatctcgc aggccctcag 836521 tcagttcatc caaatagctg gaaatggagg cccaaacact ttggtgttca gctgatttat 836581 caagctttcg gagtccttca tccagccctg tttcaataat gcggcgaaac atctcctcag 836641 tgcttgaaaa ataaagatag acaccgcccc ggctgaaacc tgactcttct acaacatcct 836701 tcatcgtcgt taattcgaat ccttttcgtt taaaaaccgt tttggcagcc tctaaaatct 836761 ctgcctgccg tttatccttg tgctcctttg ttacttttgg tgacaagata tcgcctgctt 836821 tctgcaattt tcttacctat aagtgtaatc aacccaatca tgatcagcaa gcagccacag 836881 acaagaaaag caagtgatac accgatccat tccgccagca cgcccccgcc cgccatgccg 836941 aggatagagg cgagggttgt cgcactctga atagcgccga acaccctacc gctgtaatcg 837001 acaggcactg ttgtttgcac gagaatctga aatggaatat ggacgaggcc gaaagccgcc 837061 cccatgatga aaaaagcaaa tataaagaga gtgatgccgg caattcccat accgcttagg 837121 aatggcgcac ctccagttgc tagtccaaga agaagggttc cagctgagaa ataaagcaaa 837181 taagaagtga ttcgccgtct gccggtaatg gccgctgtaa ggagcatccc ggctccgctt 837241 acggccatgc accagcctgc cagctcgggc ggagctcctg aaaaggagcg gataagaata 837301 atcgcttggg aatcaccaat ctgcaaaaca aagagaacga cacaagctgt tagtaagcct 837361 gttaatagaa gcggcatccg tttcaaaaac tgaaggcctt ccttgataga agtaagtgct 837421 gctgtttttt cttgaggtgt attggctttt tgtaaaaaag catctctggg aaggaaaaac 837481 aaaatgacag cggaaagaaa gaaggcgccg gcgtttatat aaaaaacaga gtgtatcgag 837541 aaagcagcga tcagcgtgcc gccaagggca gggccgaaga tttttgagct gttatcaatg 837601 atgctgctga cggaaacggc ctgctgaatg tgtgcttccg gagccaattc cttaagcttt 837661 ccgtttttag caggtaaaaa aagtgaagaa aaacagctct gaacggatag caatacgtaa 837721 agctgccaaa gctcactgac ataaacgcag ctgataacag tgagggcacg gccgatttca 837781 gatagaaaca tgatcgtttt tctgtcaaaa cggtcggcaa gcagacccga tacaggtccg 837841 agtacaatga caggcaaagc aaacgacatc attaaaagcg acatatctaa tggagaagca 837901 tgaagctgaa aagcggctaa tgttagcacg gccaaaatgt gaagccagtc tccaagtgaa 837961 gaaatggttt gcgaggctaa cagtgtcatc agtccttttt gattgcgaaa caacggtttt 838021 tccatgattc atcctcctga ttattaaaat gacactagtg tcgtttttaa ttgtatggga 838081 aaaagacaca atatacaatc tttttcttgt aaaataaagg agaagattga atagaaggga 838141 gaacattcat gacatcagtc aatctaagct acccaatagg agaatacaag ccgagggaat 838201 ccatatcgaa ggagcaaaaa gataaatgga ttcaagtact tgaagaagtg ccggcaaaat 838261 tgaagcaagc tgtagaggtc atgacggaca gccagcttga cacaccgtac cgggacggtg 838321 gatggaccgt tcggcaagtt gttcatcatc tggctgacag tcatatgaac agctatattc 838381 gttttaaatt gagcttgacg gaagagacac cggctatccg tccgtatgat gaaaaagcat 838441 ggtcggagct aaaagactcg aaaacggcag atccgagcgg ctcactcgcg cttttgcagg 838501 agcttcacgg aagatggacg gctctgctcc gcaccctgac ggatcagcaa tttaagcgcg 838561 gattttatca ccctgataca aaggagatca ttaccctgga gaacgcgctc ggcctgtatg 838621 tctggcactc acatcaccat atcgctcata ttacggagct ttccagacgg atggggtggt 838681 cttaacgctt ttgccggcgg aaagccggaa tactgatagc agcaatcacc agaagtgaga 838741 ccacagcagc cgctgcatat aaatgatcat agccgctggc gacactcgca tgaatggcgt 838801 cgcttatcgc ggttttgact tcaggaacgg gaatgcgttc gatttgttct tgtaaagaag 838861 aaacttcaga actgtcgatc tccggaatca tctgcatcgc cttttctgaa tatccgctgt 838921 ccgataagcg gctgttgatc tcatcaccta tttggtcaaa cccggctgtg ataaaacctg 838981 cataaagagt aggcgccaag gtcagtccaa tttgccttac taatgaaagc gtgccaagag 839041 ctgtaccctt atttgttttt gccgcttctg atacaaggac gttcagcgga gcgcctaaca 839101 gaaagccaaa accgatccca gctgccacac ttgcgatcac aaactcccat ttttccgtga 839161 cccagagcgg aaataaagca aaccccgcac atgagatgat tcccgaaaga ataacggttt 839221 ttacaggacc ttttttgtcg gtaagtgctc cgccaagcca agcgccgatt ccggaagcca 839281 acgcaagcgg tgtcatccaa tagcctgctt ttgcggcagg gacacccaaa tactgttcga 839341 catatgacgg gataaaaatg actgccgcca agagcccccc ggataacaaa ccgatgataa 839401 gcgtgcgctg aaacatatgg tttcgcagca gagaatacgc caaaatggga tcgcctcctc 839461 gcatttcaac tctcttttca tacgagataa gcgctgcaaa acagagtatg ccaaaaataa 839521 tacatccata aacctccgga ttccccaagc tgtgtaagag atttgccccg tcaagattgg 839581 tcatgccgta catcacagct aaaatcgaca gggacaaaag gaagattccg gccgcatcga 839641 ggcgcttagc ctcaggtgct tttgtttccg cgataaaaca tgcgccgaaa acaaccaata 839701 gcacggcaat cggcaaatta atcaaaaata gccaatgcca agacccggtc caatcaagca 839761 gaaagcttcc gatatttggc ccgagcacag cggccatccc gttcattgcg ccaagcagcc 839821 caagcgcctt cccctgtttt tcctttggaa gggtcgcgag aatgtgagag ctgccgatga 839881 tgaaaatccc gccgcctcca agcgcctgaa tcagccgcga tatcagaaag agcgggaagc 839941 tttggctcaa agcaacaagc aaagaaccaa gtccgaacag gcaaacctca atgagaaaga 840001 gtttttttct gccgtagcgg tcggaaagtt ttccgacgat tggcacactg acgctaagac 840061 cgagcgtata aagggtaatg ccccatgatc cccaggaagg ggaaacggaa aacgactcgt 840121 ttatcgttgt taaagcagcc gaaataattc cgttatctaa agcagccata aacacgccaa 840181 tcgtaaacag gctgattgcc cacttttggc ttttctgctc tgttaatgct tcagacattt 840241 tcgtcaactc cttttagttc acttgaaata tattattcat tttaaatgaa ctaaatgtca 840301 aataaaaaaa gcctgctccc gcagtttgcg gatgacagac ttactgattt attctttttt 840361 cgcattctct aatgctcttg aaaggataga cagcccttcg taaacagcct gcttttcttc 840421 aggggacagc agctctaatg aacgcttcaa tttcaggtgg cccttttcat acaaaccccg 840481 gaaaatcttt ttcgcattct ctgtcaactg aacaactaca gagcggcggt cctcttcaga 840541 atgtgagcgt ttgacaaatc ctgatttttc aagccggtca agcagcccag ttgtattgga 840601 cagggaagcc cccatttttt cagcaatgtc gctcactttc aatgttccat ggttgtttaa 840661 tagcatcagc accttcattt gcggcatgct catatccagt ttcatccact cggacacatc 840721 accgagcccg gcggacgtta agactttcat atagagcacc catatttccc gttcctccga 840781 tgaaagaatg ttttcgttta agactgttgt atcgtgtaaa ttatattcca tttcatcact 840841 tcctcatcat tcactcctct taccatatta ctcgattttc actcctgaaa gaaagtgagc 840901 agaaaccgca tgcgggactt tgtccgaaaa ataacggtag tgtataatga gttggagatt 840961 attgggggag aggatcgaac tagaatatga ttggagagac cattgctgat taaaaagaat 841021 gctttatcaa tattaaaaat cgtttttcct attgctgttt tgctatttgt tatttatcaa 841081 tcgaaaaaag aactgacaaa tctgtcattc aaacgtacgc tcatggtcat caacggactg 841141 gaacgaacgg atttattcat gcttgtgttg atcggcttgc tggctgttgc ggctatgtcg 841201 ctgtatgatt acgtcctgaa gtactcactg cgcctatcga tcacaaacgg aaaagttttc 841261 agggtttcct ggatcgccaa ttcatttaat aatgtgttgg gattcggcgg tttagccgga 841321 gtcgggttaa gaatgatgtt ctataaggag catacgaaag accataaggc actcgtgaaa 841381 ggaatcgcct ggctcacatc atctatgctg ctcggattat ctgttttcag cattttcgtt 841441 gctgcgagag tgctgccagt tgatgaagtg attcatgaga agccttggct gtgggcggtc 841501 gttatcggtt ttgcactgat attgccgtta tctttagcgg tgtccaaaat aaaagaccgc 841561 aaagctgggg acgaagagaa tgcggataaa gtgaaaaatc cgattttcgc atatattgga 841621 gcttcagttg ttgaatggct catggccggg accgtcatct attttgcttt gttcgctatg 841681 ggcattcatg cagatatcag gtatgtgttc ggggtgttcg tcattgcggc gatcggagga 841741 atgatcagcc tcgtgccggg cggcttcggc tcgtttgacc ttttattttt gctggggatg 841801 gagcagcttg gctatcatca agaggccatc gttacttcta ttgtgttgta caggctcgcc 841861 tactcattta tcccatttat cttgggactg ttctttgccg ccggcgacct gacggaaaat 841921 acaatgaagc ggctcgaaac gaacccgcgc atcgcaccgg caattgagac gacaaacgtt 841981 ctgcttgttg ttcagcgtgc ggtattagtg agaattttgc aaggctcgct ttcccttatt 842041 gtgttcgtag caggtctgat tgtcttggcc tcagtttcct tgccgattga caggctgacg 842101 gttataccgc acattccgcg cccggcgctt ttgctgttca acggcctgtc cttaagctca 842161 gcgctcattc tgctcatttt gccgatcgag ctttataaac ggacaaaacg ttcctacacg 842221 atggccatta cagcgcttgt cggcggcttt gtgttcagct ttttaaaagg gcttaacatc 842281 agcgcgatat tcgtactgcc gatgattatc gtattgcttg tgctattgaa aaaacaattt 842341 gtccgcgaac aggcatccta tacactggga caattgatat tcgctgtggc gctgtttact 842401 gtggcgctct ttaactacaa tctgatcgcg ggctttattt gggaccggat gaagaaggtg 842461 ctgcgtcacg aatatttcgt ccacagcacc tcgcatatta cacatgcaac catcatggcg 842521 atcatcattg tgccgctgtt cttcttgata tttacagtgg tctatcataa gagaacgaaa 842581 ccgatcggag agaaagctga ccctgagcgt cttgctgcgt ttctcaatga aaaaggcggc 842641 aacgcgctga gccatcttgg ttttcttgga gataagcggt tttatttttc tagcgatgga 842701 aatgcactgc ttctgtttgg gaaaatcgcc agaaggctgg tcgtgctcgg cgatccatct 842761 ggccaaagag aatcattccc gctcgtgctg gaagaatttc tgaacgaagc gcatcagaag 842821 ggattcagtg ttttgttcta tcaaattgaa cgagaggaca tggcgctgta tcacgatttt 842881 ggctacaact tctttaaatt gggtgaggaa gcatatgtag atttaaatac atttaccttg 842941 actgggaaga aaaaagccgg ccttcgggca atcaataacc gctttgagcg ggaggagtat 843001 actttccatg tggatcatcc cccattttct gatgcgtttt tggaggagct gaagcaaatc 843061 tcagacgaat ggctcggctc gaaaaaagag aagggattct cgctcggatt ttttgatcct 843121 tcctatttac agaaagcgcc gatcgcctat atgaaaaatg cagaaggaga gatcgttgca 843181 ttcgcaaatg tcatgccgat gtaccaggaa ggagagatat cggtcgatct gatgcgctat 843241 cgcggcgacg ctccaaatgg cattatggac gcattgttta tccgtatgtt tttatgggca 843301 aaggaagagg gctgtacgtc atttaatatg gggatggcac ccttggccaa tgtcggcact 843361 gcctttacat ccttctggtc cgaaaggttt gccgctgtca tttttaataa tgtcagatac 843421 atgtacagtt tcagcggcct aagagccttt aaagaaaaat ataaaccgga gtggcgaggg 843481 aaatacttag cgtatcggaa aaacagatct ctttctgtca ccatgttcct cgttacacgt 843541 ctgattggca aaagcaaaaa agactccgtc taataagacg gagtcttttt ttatttcgtt 843601 tttaagaagt aggtttcaat atcatcaagc aggtagtttg cggctttaat tccgcctgcg 843661 gttgtccata cgacgtcatc gacttcatgt gcattacctg acttcacggc cttcaggttt 843721 ttccatagtg aactgcttgt ccactgattg gcccattttt cattttcttt tgcattatcg 843781 gctttataag tgaaataaaa cagcacatca gcatccatat caggaataga ttctttactg 843841 tcggttgaga acgtaaattg gtccttttgt ttcttaaaca gttccacttg tttttcaggg 843901 cgtttgaagc caagctggtc taaaataatc ccaggaaatg aatcggtata atagattctt 843961 gattcaccgg ataaaaagcg tacgactgaa acggttttgt ttgtctggtc gcccagcttg 844021 ttttttaaat cagaaacacg tttatcaaaa tcggcaatga cttccttgcc tttgtccgcc 844081 ttattcaccg cgttggcgta tagagtcagg ttatccttcc agttcccggc caaagattca 844141 gcaaaaacag tcggcgcaat cgcatttaac tgatcataaa ttttttcctg gcgcactttg 844201 tttccaataa tcaaatcagg ctttaattct gcgatggctt ccacattcgg ttccgtttca 844261 agaccgacgt ttttaacacc tttcatgtca tctttcagat agtcatacca cgggtcgccc 844321 ttccatgact ttacggctcc gaccggctta atgccaagcg ctaagagcgc ctctgttcct 844381 tcattagtta aaacaacaat ccgttttgga ttggcgggga tgttgtctga tgtccccatt 844441 gcatgtttga ccgttcttgt tttgctgctt gacacctcgc tgttgcttga actttctgaa 844501 ctattacagg cagaaagtac cataacggcc attaaaaata cgaatagcat gctgatatgc 844561 tttttcatct ttttcctccc aatattgaaa ttcattatca tttagatcat aataagcagt 844621 gttaagagtg tcaatcccta attgaggatt attctcaaaa acaaacatta catagtaaat 844681 aactaggaga attagatcat gatctgcaaa aaggcatctt caaaatggat tgtgttagta 844741 tgtctgattt tcattttact gacggctgtc tgcgcaagcg tcgtgtatgg ctatacaggt 844801 acgtcatgga gacaggtcta tcaggcgttt acttccttca atggaacaaa tgagcatgtc 844861 atcatcaagg atgtcaggct tccgcgcgct ttggttgcga cagtcgtcgg cgcctcgctt 844921 gcagccgcgg gcgctctcat gcaggcgctc acaaaaaatc cgcttgcgtc accggggatt 844981 ttcgggatta acgccggtgc aggttttttt attgttgccg gatcgttttt tctgcatatt 845041 cagtcacctc aggcattagt atggagctcg tttctggggg cagcatttac cgctgcgatc 845101 gtctatgcag caggctcgct tgggagggaa gggctgacgc caatcaaact gacgctggcg 845161 ggagctgcca tggcagccat gttttcttct ctgacacagg gcttgctgtc tgtcaacgaa 845221 ctcgagcttg cccaggtgct tttttggctg actggctctg tgcagggccg gagtctggat 845281 ctgttgatga cgatgtttcc atatgcagcg gcagcgctgg taatctgctt ctttctcggc 845341 caaaaaatta atctcctcgt tatgggagaa gatgtggcaa aaggactcgg ccaaaaaaca 845401 ggcctgctga aatttgtgat ggcgctttgt gttgtcatgc ttgcagggtc cgctgtcgcc 845461 attgccgggc cgatttcttt tatcggcatc attattccgc attttgcccg ctttgtcgtt 845521 ggtaatgatt atcgctgggt tctgccattt tccgctgttt tgggtgccat tttgcttgtt 845581 tgcgcggata tcggtgcgcg atatatcatt atgcctcagg aagttcctgt cggggtcatg 845641 accgccatca tcggaatgcc tgtgtttgtg tacatcgcaa gaaggggggc gaagctatga 845701 aacttcgttt tggcgttact gcggctgaaa agaaagcatg gatcgtcttt ttggttttac 845761 tggggttaac agctgctgta ctcatcataa gcgctggtct cggacaaagg tttattcctc 845821 cctgggatgt agcaaaaaca ttctttggtg caggttccaa gctggatgaa ctgatgatca 845881 tgtcgttccg catgccaaga attttgacgg ctttatgcgc cggtgtctgc ttggcagcgg 845941 caggcgcgat attgcagggg ctcgtcagaa accctctcgc atctccggat attatcggaa 846001 taacaggagg agcggcggta gcggtcgtgc ttttaatgat gttcttctca gaccgcagca 846061 gttcacttac gatcagtctg tcatggcttc cagcagccgc atttatcggc gcatcggctg 846121 tcgggctcat cgtctattta ctggcataca aaaatggcgc ctccacattt cggctggtgc 846181 ttatcggaat cggattttca atgtcggcgc aggcgatgac taccctgttg atgatcaaag 846241 gcccgattta ccgagcatca caagccaatg tgtatatcac tgggtcagtt tatgggtcaa 846301 actggcagca tgtaaaaata gctattatct tatctgtcat tctcttattc atttgttttg 846361 tcgcgctaaa aaatatgaat atacaggtgc tgggtgaaga tattgcggcg ggtgcaggaa 846421 gcgctgtgca gcgaaatcgt tttttcttgc tccttttgag tacggctctt actggttgtg 846481 cagtttcagt tgccggcaca atcggttttg tcgggctgat ggcgccccat attgcaagac 846541 ggcttgtcgg ctcatcttat ggcgcgctgc tcccagcgtc ggcacttatt ggagctctgc 846601 tcgttttaac agctgatatc gtcggcagaa ccttatttgc tccggtggaa gtgccggccg 846661 gcgtctttac agcggctatc ggcgcacctt attttattta tttgctctat aaaacaagaa 846721 attcttaatc gttacaccca ttttcttaaa aaagaaaatg ggtttttttg ataatgactg 846781 aagattcgta attatttttg ctatactgac agagacattg ataaagaaag ggcggcagat 846841 gaatgaaaga agcagaggta ttaaaatatg aagcatttac aagcagtccc ggcaaaggaa 846901 accccgcagg cgtcgttttg cagggagacg attatacgga agacgagatg cagatcatag 846961 ctgaacgtgc cgggtattca gaaacctcct ttatccgaaa aagcgagtcg gccgatcttg 847021 aactccgtta ctttacccct ggacacgaaa tgaatttgtg cggtcatgcg acagttgctt 847081 ctctttacgc attatgtgag aaaggaatgc tggagagcgg taaaacgtac agcatccaaa 847141 cgaaagcggg tatcctgcct gtgaagattt ctgaaaaaga tggccgcatt catatcacgc 847201 ttgaacaggc ctctccgcaa ttcaaaccat ttacaggcga tcggaaaaaa cttgcggacg 847261 cactgggtat caccgatgaa gattttcatg aagaccttcc gattgtgttt ggcagcactg 847321 ggatatggac agccatcgtt ccgcttaaat cattggaggc ttccaaaaaa atggtgccag 847381 ataacaaaca atttccggaa gtgttagttg atctgccaaa agcttcagtc catccgttta 847441 cctttgaaac cgtccatccc gacagcgacc tgcacgggcg ccacttttca tccccgtatt 847501 cgggaacgat tgaagacccc gtgaccggca cagcatccgg cgtgatgggg gcttatatga 847561 aacattatgg caatgccgag cagcataaat ttatcattga acaagggcag gaaattggaa 847621 aagacggaaa agtggagatc gaaatgaacg aagccggcgg ccatgtgaaa gtgaacatga 847681 caggaacagc cgtttactca gaaacccgta ttcttaaaat ctaatacgga tgatggttta 847741 caaaaagatg cactttccgt tatcattatg aaatgataat cattttcaat tgcataggaa 847801 ggtgagacgg tatgcctcaa accgaacaaa tacatcagca ttcagtactg agggacatca 847861 tacgcagcag aagatcgatt cgaaagttta aacaagagcc agtaccttca gcagtcattc 847921 ttgacatgct tgaaacggca aaatatgcgc caaatcacag agtgacagag ccatggagat 847981 ttatttacgt ttccagtgag acaggtaaag cgaacctcat taatacattt gcagcgttct 848041 ctaagaaatc caagccggat atgacagagg aaaagcttca aaatttcaaa aacacacttg 848101 ggcgcgttcc gggatttctc ctcgtcgtgt ttcaggaaga tgaaaacgaa agagcgcggg 848161 acgacgattt tgcggcaaca agctcgttga ttcaaaatct tcagcttctc gcttgggaaa 848221 aaggaatcgg catggtttgg aaaagcggaa aaatccttta tgacaaagaa gtccatcagg 848281 cctttggttt acaggataat gagcgtttcg ccgccatcat acaaacaggt tatcctgacg 848341 aggcgccgga agtgaaaaaa cgcacaccga tccgcgaccg attcactgaa atgtaaaaaa 848401 ccccttgtct caaacggaga caaggggttt ttcattaacg agatttcttt ttcgctctgt 848461 tgtcggctgc tttcgcacgc tcttgcgctt cgcggtcatc tgcatcagca agctcggttg 848521 aatattcttc gtaaacgccg tcagtttccc tttttaaggc atcgggaact tgtggaagct 848581 tttgtttgtt tttatcacgg tttttgtgga tatgatttct gcccatatca aattccccct 848641 aaaaagtgat atcaaacaaa tatagtattt ggttttaagg ggctatgtat tcctacttcc 848701 gcttagcagc tttttccgct tttttaaatt cgcctgaata aagaacttcc tgcatttttt 848761 tcaggttggc gccttgctgg tgcttctccc tctttttttc cataaaaagg acctccttca 848821 accatgttat tcttaaggtt gacgcttcct gctgttttta tacagtcttt cggtccgcta 848881 tcagctgtga gagtgcaaat tcaagatccg aatatgtaaa acgaaatcca gaggttatcg 848941 cttttttcgg aagagcgcgc tgtcctttca caatcaaaag actcatttca cccaatgctt 849001 ttgataaaaa gaattccggg acggggagcc agtgcgggcg gtgcttcacc cgtgcaatcg 849061 tttttccgaa ttgcttcatg tccacaggat tgggcgcggt gacattcatt gggcctgaga 849121 tgccggcgtt ttccaccgca tatcggatca tctgggccgc atcctcgaca tgaatccatg 849181 acagccactg ccttcccgtt ccgatcgttc cgccggccag aaacttatag gggagaatca 849241 tgagcgggag agcgcctttt tctccaagca tcacgccaaa tctcgcataa actgtccgga 849301 tgcccatcgc ttcaatatgc tgtccttcct tttcccacag gtgtgcagta tggctgagaa 849361 aatcctcatc tgacgttgca gaatcctctg tgaaagtttt ctcaaggctt gtgccgtaaa 849421 tgcccacggc actggcttgg atcaatgtct tcggcttctc cttctgtttc tgaataagcc 849481 gctgcacttc acgcgtcgca ttgatacggc tggagagaat gtgctgcttc gttttttctg 849541 tccagcggcc aaaaatcgat tttcccgcaa gatttatcca gacatcaata tgaggaagtt 849601 cctgctccgg tgcggctcct tccgacagcc attggacata tgtcatattt ttttgttcag 849661 tttcccttgc gtttcttgat aaaatataaa catggtgtcc ctggcgggta agaacgcctg 849721 tcagatgctg gccgagaaaa ccggttccgc ccgtcattgc gatattcatg aacatctctc 849781 ctcatcgttc taataaatat actttacctc attgtaataa aagaaaacgc gtttcaggcc 849841 tgagaaggga gattaagatg ccgtttatta caaaaatatc aacgcaaaaa aagaatacgg 849901 aacgcttcaa tatttttctg gatgataaat acgccttcag cgtggacgcg gatgtgctcg 849961 tgaaatttga gctcaagaag ggaaaagaac tcgatgatct tgacatcatt gagattcaat 850021 acggcgatga agtgaagaaa ggcttcaacc gtgcgcttga ctttttatcc tatcgaatgc 850081 ggtcgacgaa agaggtcgag gatcacttaa agaaaaaaga aacctcgccc cccgtcattg 850141 cggaagtcat ccataggctt aacgattaca agtacttaaa cgaccaggaa tttgccgcag 850201 cctatgtcag cactcacaaa aaaacaaacg gaaaaggccc tgatgttttg ttcagagagc 850261 taagagcgaa gggaattgat gacgatacaa ttaaggaggc gctaagttcc ttttcctttg 850321 aagatcagac aagagaagcg gtcaagcatg ttgaaaagct tctcaaaaaa gataaaaagc 850381 tttcgacgaa agaactcaaa cagcgcgccc agctgcagct tcagcgcaag ggcttctcat 850441 ttgatgttat cagcgcggcg atggatcaga ttgaatatga aaatgatgaa gacacagaga 850501 aagaagcgct gcgccttcac gcggaaaaag cgtttagaaa ataccgctat gacggctcat 850561 atgaaagcgc catgaaggtc aaacaatttt tattccgcaa aggattctca ctcgatttaa 850621 tcgagcaatt actgcaggaa gaggagtact gaaatggaga aacgatacag tcaaatgaca 850681 ccgcatgaac tcaataccga aatcgcatta ctttctgaaa aagcaagaaa agccgaacag 850741 catggaatca taaacgaact ggcagtgctc gaacggaaaa ttacgatggc aaaagcatat 850801 ttgctgaacc cggaagatta ctcaccggga gaaacatatc gtgtggaaaa cactgaggac 850861 gagtttacca tcagttattt aaatggcgtt ttcgcatggg gatacaggac ctcttcccct 850921 cagcaagagg aagcgctgcc aatctcagta ttgcaagaaa aagaataaag cgtaacagga 850981 ggctgatgat cagcctcttt ttgtttgcag cacatttaca cgaattctta aagaaaaaat 851041 cattgaattc acttgaaaaa tcttttaaga tgaaactcgt tgttttttaa aatcaaagga 851101 ggcgatgacg ttgagtatca aaaacccatc tgtaaaattt attatatttg ttcttatgat 851161 ttgtacattt tcaatcggct atacagaata cgcggtgatg ggtattttga cgtcgattgc 851221 caatgacttt catatacagg tttcatccgc agggcttctt gtcacggctt atgcggcaag 851281 cgtttgtttg acagggccgc tcgtcaccat catttccgtc aagcttccga gaaagcctgt 851341 gcttcttggg ctgatggcga tatttatcct ttccaacctg atgagcgcac tggcgccgaa 851401 ttttgcggta ttggccattt caagaatttt atctgcgtcc attcacggcg ctttcttcgc 851461 gattgccatg gtattcgcaa gtgaaatggt tccgccggaa aagcgtgctg cagctgctgc 851521 ttcaatgaac ggcggactga cagtggctct aatgcttggt gttccattcg gctcttatct 851581 cggagatgtc ctgaattgga gagcggtgtt ttccatcatt acggcacttg gtgtcatcgg 851641 atttttaggc cttatggctg ccgtgccgaa cagaaaacca aaagtgatcc caatgcttat 851701 gaatgagtgg ggtgttttta aacacaaaca agtgctgttt tccttcgcga ttaccatttt 851761 aggctattcc ggtgtcttta tcgcctacac ctttatcgaa cccattttga ggcattcagc 851821 cggattcagc acggttggca ttacaggtgc tctctttgcg tatggattgg gaggcgttgc 851881 cgggaatttc tttgctggaa aggtaccgct gcctttgctg actcggacga tgatcggcgt 851941 aatgatcggt ttaatcggtg ttctggctgt atttccttac atcgccattt acccggctgc 852001 agccattgtg gcaacgttcc tattcggggc atgcgcattc ggcacgccgc ctcttctgca 852061 aacaaaggtc atttcctcat ctgagggcgg cacaaccatt gccgcagctg tcagcgtatc 852121 agcatttaac cttgccaatg cccttggtgc atggatcggc ggaatgattt taaacggaac 852181 aggctcttat tcctggctgt ttgcaggagg tgcgcttatg accgcatgcg gacttgtgct 852241 ttctaccttc gcacacttat cagaaaagaa gagcgtctac gaatatcaag tcaataaagg 852301 gtaaaaaaca gctgcagtgt atgcagctgt tcttctttac cgtttgcctg aggctctcat 852361 tctttcttga ggatgctgat tgatagatcc gtcagcacgc tttgaagcat agtcgtcctt 852421 tgctctcggt tcaccctgaa atttgttttc gttttcgtaa ggaaatcctt tttctttatt 852481 tcggaccatg tcatatcccc ctaggttcga gatcaaaaag ttgcgtcttt tcagatgaag 852541 acgtaaggtt agtatatgga gaacaccacg taataaagcg ttattttttt cctgaagaaa 852601 ggagactgca cacatgaata tgtacattga gaaactgact aatctgcttc tggaaaagaa 852661 cgagatgatc agctatatac aggcaaaaac gtgggtggaa ttgttatgga gcgatttcga 852721 agcaacctac gcaaaagccg gacacgccta tcaaggtgaa aaaatgactg aaaaaatcgt 852781 cacacaatgg attgaaaact atggcggcca gctccacctt tttcaaagct cccgtaacga 852841 cgtgaatgat tacttaaatc aaagcagagg ccttttgcat taaaaacctg ccgttaacga 852901 ccggcaggtt ttttcatttt cttaaaatta ccttaacagg aagaaatcat aaacaaaaca 852961 tgtttcacca gcctgtcaat cagggaatac cacttatatc ttgtcaaaat gcgaggagga 853021 gctttatatg aaaaagaaac aagtaatgct cgctttaaca gctgccgcag gactgggttt 853081 gacagcactt cattccgctc ccgcagcaaa agctgcgccc cttcacgaca tatctgtcag 853141 catgccatca tccgatactt acatcataaa agcaggaaag ctgaatgtcc ggactgagcc 853201 aaatcatgaa ggtgatattc tcggcactgt atcatcagaa caaaaggtaa aagtcgatag 853261 gttcgtaaat gccgattggg ctcaaattca tttcaaagga aagaaagcat atatttcaac 853321 tcacttttta atgaaaaccg caagccaagc gaaaacaacg aaacagacag ccttctatac 853381 accgacgccc gaaaacggaa aagctaagca gctctcatct ggaacagagg tgacaatact 853441 tgggtgggga ttcagtgaaa acggcggatt tgacttcact tgggcgttcg tggattatgg 853501 cggagttaaa ggctatattc acacaaagga tttacaaatg cgataaaaag gcaggccgag 853561 gcttgtcttt ttgcctatgc atgaaacatt tcttctttct gcacgtaaca atgagaaagg 853621 agatgatgat atgacgggtt tagtcggcgg agggcttatg atcattgcgg gcatactgat 853681 caaactgttt cctcccaaat cgatcaacag tgtgtacgga tacagaacga gacgctcaat 853741 gtcagatcaa agattatgga atgaagcgaa ccgttacagt gcatcattaa tgatcctgtc 853801 aggcttggtg attgcgggaa tgggtttgct gctgggatca aacttgttta ttcttcagct 853861 tatcctgctg attgccgcct gtgtcataac atttatgcta acggagaaaa ggctgaaaat 853921 catgacgcac agtcaaggag gagatagaag tggacggagt taaatgccag tttgtcaata 853981 cgaacggaat cacgcttcac gttgcagccg caggacggga agatggcccg ttaattgtcc 854041 tgctccatgg atttcctgag ttttggtacg gctggaaaaa tcaaatcaaa ccgcttgttg 854101 atgcgggtta ccgggtcatt gctcctgatc agcggggcta caatctcagt gacaaaccgg 854161 aaggaattga ttcgtatcgg attgatacat taagagatga tatcatcggg cttattacgc 854221 aattcactga tgaaaaagca attgtcatcg gtcatgactg gggaggagct gtcgcatggc 854281 atttggcttc cacacgcccg gaatatcttg aaaaactgat cgcgatcaat atcccgcacc 854341 cgcacgtcat gaaaaccgta acgccgcttt atccgccgca atggctgaaa agctcgtata 854401 tcgcatactt ccagctgccc gatataccgg aggcatcact aagggaaaat gattatgata 854461 cattagacaa agcgattgga ttatccgacc gtcccgcgct ttttacatcc gaggatgtca 854521 gcaggtacaa agaagcgtgg aagcagccgg gcgcgctgac agctatgctg aactggtaca 854581 gagccctcag aaaaggaagc ttggcagaga aaccctctta cgaaacagta ccttaccgaa 854641 tgatctgggg aatggaagac cgctttttga gcagaaagct tgcgaaagag acggaaaggc 854701 attgcccgaa tggacatctc atctttgttg atgaagcttc ccattggatt aaccacgaaa 854761 agccagccat cgtcaatcag ctgattttgg aatatcttaa gaaccaataa gctaaaattt 854821 ctctccatcc gtctgtcata atggcagact ttttctgtgc gttttttttc atagtctgtt 854881 ttaaacatga caaaataaca ttaaaaatca tgaatgtcac cataaaattg taacaaaaaa 854941 caggtttaaa cgactttaaa aaaaggaata gccttactga agatttgtgt aaaactcccc 855001 taaggcaata cttaaaaaga ataataaaaa gaaggtgcct taatgaagca aggattaatc 855061 tcgattatta tcccgtctta caatgaaggg tataatgtta aactcattca tgaatcttta 855121 aaaaaggaat ttaaaaacat tcattatgac tatgaaatat tcttcataaa cgacggaagt 855181 gttgatgaca cgcttcagca gatcaaagac ttggcagcga cgtgcagccg ggtaaaatat 855241 atatcttttt ctcgaaactt tggaaaagaa gccgcaattt tggcgggctt tgagcatgtt 855301 cagggcgagg cggttattgt catggatgcc gatctgcagc atccgacata tttgctgaag 855361 gaatttatca aaggctacga agaagggtat gaccaagtca ttgcccaaag gaacagaaaa 855421 ggggacagct ttgtccgctc actcttatca tctatgtatt acaagttcat taataaagcg 855481 gtggaagtcg atttgcgtga cggtgtcggt gacttcagat tgttaagccg ccaagctgtg 855541 aatgcacttt tgaagctgag cgaaggaaac cgcttctcaa aaggcctttt ttgctggatt 855601 ggctttgatc agaaaattgt attttatgaa aatgtcgaac gaaaaaacgg cacctccaaa 855661 tggtcgttca gcagtctgtt taactacgga atggacggcg tcgtttcatt taatcataag 855721 ccgctgagat tatgttttta tacaggcatt ttcatcctgc tgctttccat catttatatc 855781 attgccacat tcgttaaaat tctgactaac ggtatttctg tgcctgggta tttcaccatt 855841 atctcagcag tgttatttct cggcggagta cagctgttaa gtcttggaat aataggtgaa 855901 tatatcggcc gaatctatta tgaaacaaaa aaacgcccgc attatttgat caaagaggcg 855961 aatatcccga acaaagacct gcctgaaacg aacgaattaa aaagcatgcg gcgtctgaca 856021 aaaatgcact gaaaatacca agcgccattg gcagtgcttt ttttgcgtgt ctattatctt 856081 aaaagcaaga ctggagaatt catatgaaaa gaaaacatat catgatctat gcggccagtt 856141 tgctggtgtc cgttctggca cacgcttttt ttgtgaaaga atgggcggaa ggcaggtata 856201 tgacaggtcc gggtgacggg cttgcgcaaa tgatcgtatt taaaaaatta ttatttgacc 856261 aatatacaca cgggaatttt ttctacaatt attcattcgg acttggcggc ggcacattca 856321 gtcagctcgg ctattatttt tctgcgtctt ttctttttct tgctgtgtct gccgctgttt 856381 ggctgcttca agccgtccag ctgatcggag aaacggatac gcttttttgg gcagagtcag 856441 ctgtttttat cagtattttc aaattgagct tgatcatctt tacgtccgct tctgtttttc 856501 attatcttct taagcacagg gcggcatcgt tcacgggagc cgtgttatac ggcgtctcaa 856561 ttatttattt ccgtcacgaa gcgtattggg aatttttcac cgatacaatg gtttggcttc 856621 cgctgcttgt gcttggcgca gaaaaaatta ttagagagcg gcgtccggcg tggtttatcg 856681 ttgcgtgttc gctgacgtta atcaacaatt tttactttgc atacataaac cttatattca 856741 tcggaatcta tgtgctgttc agatggctga tccgtttgga accacatgaa gagaaaagat 856801 ggattcaaat cagattattt ctcgtttcag gcttcatttc ttttggcatc agtgcggcgg 856861 cgtttgtgcc ggtagtatac ggttttttaa acaacctgcg ccctccatac agccagaaaa 856921 tagagtggct caatttcgat gataatatct tattttcgag ccggatcatc attgtgccgg 856981 ccgcttttct gctgtttttg tttattattt ctttttacaa aaaccgtgtg tttcgtctct 857041 ttgccgggtt gagcctgctg tttattctgt ttcatttcag tccgtatgcg gcaagcgtct 857101 ttaacggttt ttccgccccg caaaaccggt ttgaatatgt tctggccttt accattgcgg 857161 gagcagctgc ggctggtttg tcacagctgt ctgaattgaa acggaaagaa ctgctcccgg 857221 ccgcagctgt cgtcctgctt ctttacttgt atcatatcca aaggtataag ctcgatatat 857281 ggaagcctgc gaatgaaagt attctattgc tcttactcat gacaatcgca gccttgtttg 857341 ctgcagcttt tgcgaaaaaa cgggcaaaaa tggctgtgta cggtataatc attctttctt 857401 cgctgtttgt cgccaactcc tatcaaaaat acgcgctctc agaaggcggc gatttggaca 857461 gtgtgacaaa agaatatctt acaagtgagg aatacagagg gcgggaatca tctgagctca 857521 tcagacgttt acagaaggaa gacgatgacc cgctcatgag aatcgactgg atgaacgggg 857581 tccgcaataa tacgccaatc atttacggat ttaatggctt cagcgcgtat tccagcattt 857641 taaacaaaga tctgctggcc ttctattgga atgatttaag catcgatatg ggcagggaaa 857701 gcgtcagccg ttacgcgtca ttgggagaca gggcgaattt atacagcctg ctttacggca 857761 aatattatat gaccgaaaaa acaaacgaag ccagcgtccc gtacggcttc aaaaagcatt 857821 tagaaacaga gcattatgca gtttatgaga atcagtacat gcttccattc gttaaaacag 857881 cggatgccat atacagcgaa agtgagctgg accgattgcc cgctcttgcg aaagaacagg 857941 cgatgctgaa aggaattata ttaaaagatc catcaggaaa aacggagcag acaccaaaac 858001 cgtccaattt gatcaccaag tcggacatca ccgcaaaaca agcccagtat caaaacgggc 858061 tgctaaccgt aactggagaa aacggaggag agctgatcat caccccgaaa cagccatcat 858121 ccgctccggg agactactat gtcagctttt atttgaaaag caaagcaaaa gacaaaggat 858181 ttacattaaa ggtaaatgat tatgtcacaa caaggaaatc gaacaaatcg atctataaaa 858241 ccggagtaaa taatataacg gtaagagtgc ctaaatcagg ccatatctca atcaatcttc 858301 cgaaaggaac ctatgagctg agaaacatag cgctctatga agaaaattac caaacgctga 858361 aaaacgctgt aatgcaaaat aaaacagaga aagcagacaa actgaattgg aacaaaaatc 858421 gactgacctt ttcctatcat ctgtcaaaag accagtacat catgcttccg atcccatatg 858481 aaaaaggctg ggagctgaag atcaacggaa aaacacagaa gatcgaaaaa gcggattatg 858541 cttttatagg cttcaaggcg caaaagggag acaatcacat tgagctgact tactatccgc 858601 catacttcaa aatatcggcg atcatatctc tcgtcagtct gctgcttgct gttttttata 858661 taagacgtaa aaagcccggc tctatataga gccgagcttt aattttttct gaagtttttc 858721 ttcgctgaat atccatcccg tataggatga acgaatcgtg agatcatggc cgatatgaac 858781 aattgcgaca aacggataat ggcctttgct ccgataacgc aggtcgataa atctcacctc 858841 ataatgatct ttaaacgtat ccacttccca ccggtatacc ggagaaaagg acagaaacgc 858901 cgcgatgtta tcatcctgct ttgccgcatg cattacatcg gtttcaggaa caggcacccg 858961 attaaatgta tccagaatca cgacatgtcc ttccatgctt cttcctacat agaaagcatg 859021 tgctgtcgtc actgcgattc gccattgcct gaatttcatc gttggagaaa taataatgct 859081 ttcgatctca tcatgaatca tctcatgaag cttccgttta attctcagct gcatgatcag 859141 gcgcaccaag tagtagccta ccaatatgat atataagctg agaaacgtga tgccgggact 859201 cccgcctgca taccaaatcg cgatagctgc cagatggctg ataaaaataa acggatcaaa 859261 cgtattaatc agcccgagcg caacccattt tttcgaaaac ggacgaatgg cttgtgttcc 859321 ataggcgttg aatatatcaa caaagacatg cagaacgact gccagcagtg tccacagcca 859381 caggtgcaga aaatcggcct gaggataaaa taaatacaga atcgccggga tgatgacaga 859441 ccaaaacaaa acggcgggaa ttgaatgggt aaatcctctg tgattcctta tataaacagc 859501 attgttttta agctttaaca cagtatcaat atccggagcc tgagagcccg caagcgttgc 859561 gatcataaca gcgtgagcca ttgccggatc tgatccgaca acaggatcaa gcgtcgcaat 859621 accgcccagt gcgatgccca taacgacatg tgtgcccgta tccataggtg acctccttgc 859681 agggtgatcc tgcacattca ctttgtaaga aattccccat tttcatatac ccaattttta 859741 aactgattca atcgttctca tatgtttccg ctttttcttt attactattt aatgtaacat 859801 attatcgtac tgtgccctta gtgtacaaca aaaaacagtc taaagaaaag cggggcgcga 859861 aagactgggg agaaacacat atgaacgtac ttgaagacaa attaaaacaa aaagacatac 859921 agcaatttcg cgatgattta atctcatggt ttgaacgaga gcagcgcgtt ttgccgtgga 859981 gagaggacca agatccatat aaggtgtggg tatctgaagt gatgctgcag caaacgagag 860041 tagagacagt gattccttac tttctccggt ttgtagaaca attcccgaca gtggaagcgc 860101 tcgctgatgc tgatgaagaa aaggtgctga aagcatggga agggctcggc tattattcgc 860161 gagtcagaaa cctgcaaagc gcggtaaaag aagtgaaaca ggaatacggc ggcattgttc 860221 ctccagacga gaaagatttt ggcgggttaa aaggcgtcgg cccttataca aagggagcgg 860281 tgctcagcat tgcctacaat aaacccattc ccgcggttga cggaaatgtg atgcgtgtca 860341 tgtccaggat tctatctatt tgggatgata ttgccaaacc aaaaacaaga acgatctttg 860401 aagacgccat acgagctttt atttccaaag aaaaaccatc tgaatttaat cagggcttga 860461 tggagcttgg agccttgatc tgtacgccaa aatcaccctc atgcctgctt tgcccggttc 860521 agcagcattg ctcagcattt gaagaaggca ctgaacggga gcttccggta aaaagcaaaa 860581 agaaaaagcc cgggatcaaa accatggccg cgatcgtact gactgatgaa gacggacaag 860641 tgtatatcca caaacggccg tctaaaggtt tgctcgccaa cctgtgggaa ttcccgaatc 860701 ttgaaacaca aaaagggatc aaaactgagc gtgaacagct cattgctttc ttagaaaacg 860761 aatatggcat acaagctgat atcagtgatc tgcaaggtgt agtcgagcat gttttcaccc 860821 acctggtatg gaatatttca gtgtttttcg gtaaagtaaa acaagtgtcg gataccagca 860881 agctgaaaaa agtaacgaaa gaagagctcg aacaatttgc gttcccggtg tcacatcaaa 860941 aaatctggaa gatggcagga gaagcagccg ccatctcggc tgctccgtaa accattctta 861001 atcgtaagag acgcgcgtgc cgtggctgta gtccgcttca ttgcgcttca ttccgccgcg 861061 cgcttcaatt tcttgcgtta attcccggta ttttgattgg ccttcttcgt tcaaataagg 861121 cataatttgc tgaaaggcat gatgaaaata agcgagttca ctgttcttcc aatctttttt 861181 ggaaaccatg ttcaattcgc tcatatcacg tccgacatac ataacagaag acccccttta 861241 aagttcttgc cattattgtt tgtggaaata aaagaactat acgctacaag gagatgagga 861301 aaaatggaac aaaataaatg tgcactcgta acaggaagca gccgcggtgt cggaaaagcg 861361 gccgcgatca gacttgctga gaacggctat aacatcgtca ttaactatgc acgcagcaaa 861421 aaagcagcat tagaaacagc ggaagaaatc gaaaagcttg gcgttaaagt gcttgtcgta 861481 aaagcaaacg taggacagcc tgcaaaaatc aaagaaatgt ttcagcaaat tgatgaaacg 861541 ttcggcagac ttgatgtttt tgtcaataat gccgcttcag gagtactaag acctgtcatg 861601 gaattagaag aaacacactg ggactggacg atgaacatta atgcgaaagc attgcttttc 861661 tgcgctcagg aagctgccaa gctaatggag aagaacggtg gcgggcatat tgtcagcatt 861721 agttcattag gctctatccg ctatcttgaa aactacacca cggtcggtgt atcaaaagca 861781 gcgttagagg ctttaacccg ttatcttgcc gttgagcttt caccaaaaca aattatcgtc 861841 aatgctgttt caggcggagc gatcgacaca gatgcgctga agcacttccc gaatagagaa 861901 gatctgcttg aggatgcgcg ccaaaatacg ccggcgggac gcatggtcga aattaaagac 861961 atggttgata ctgtggagtt tctagtgtct tccaaggctg acatgatccg cggacagaca 862021 attatcgttg acggcggacg ctcactgctc gtttaaaaat ttttaaaaaa gaggaatagc 862081 tatacgatca cctgcacatt ctaatgaccg tggaggtgat aacaatggct aactcaaata 862141 acttcagcaa aacaaacgct caacaagtta gaaaacaaaa ccaacaatca gctgctggtc 862201 aaggtcaatt tggcactgaa tttgctagcg aaacaaacgc tcagcaagtc agaaaacaaa 862261 accagcaatc agctggacaa caaggtcaat tcggcactga attcgctagt gaaactgacg 862321 cacagcaggt aagacagcaa aaccaatctg ctgaacaaaa caaacaacaa aacagctaat 862381 cactgaaaca gaaaaaagca cttcatcttc gggtggaagt gcttttttct gtttgaaaaa 862441 cgacaaaact tgtggaaggt ctacagaatg agtcaaaggg tttgctttat ggagatcgaa 862501 atgattaaag gaggaaatgt ttatactttc atcaggctga aggaggaacc gatgaccgaa 862561 tttgaaaagc tggtaagtga acagatgaaa acgatggata agcttctcga tctccaatca 862621 gagctcgacc gctgcaaaca aattgaggcg gaactccggc atttggaaag ggatgcaagg 862681 ctgcgtggga ttcaggctga aattgcggta aaacggaaac accttgccga tatacaggat 862741 atgtttcaaa agcagacaga gcaggtcatt cgttcatatc gcagctcaga aaagccgtct 862801 tcctttgtgt agtgcaggaa tgtgccattc cccggccgga atggctcttt tattttcatt 862861 tttcaatttg taacgttata ataggtaaaa gacgttgtcg gtaagcaaat ttggacatac 862921 taactgtagg gctttataga aagtagggga gaaatatggg ctatcccaag gaaggagaaa 862981 ccattcaaat tcacagctat aagcacaacg ggctgattca tagaatttgg aatgagacaa 863041 caatcttaaa aagtacagaa atgtgtgtca tcggagccaa tgaccggacg atggtaaccg 863101 aatcagacgg ccggacatgg ataaccagag agcccgcaat ctgttatttt cacgcaagac 863161 aatggtttaa tgtcatcggg atgctgaggg aagacggggt tcattattat tgcaacatca 863221 gttctccgtt tgcctatgat ggcgaagcaa ttaaatatat tgattatgac ttagatgtta 863281 aggtttttcc tgacatgacc tacaatattc tcgatgaaga cgaatatgat gatcatcgga 863341 aagccatgaa ttatccaaaa gaaatcgaca gtattttaag agactactta aatacgctgc 863401 tccattggat tcaccagcgt cagggaccgt ttgcgcccga gtttgtcgat atgtggtatg 863461 aacggtattt gcgctataca aaataatggt tacgtaaaaa cctgttgcgg ggtacaacag 863521 gtttttcaca tgggctcaca cacatcatga taaagagaga gggggaatca accgtggggg 863581 ttatgaaacg ctacatgcaa ttcgtcaaac cttataagaa gcaaattttc gttacagtgt 863641 taatcgggat cgtaaaattc tccattccgc ttgctctccc attgcttctg aagtacgtag 863701 ttgacgacat tattcaagga ggcggcacgg ccagtgacaa aaccacgtca ttgttcacga 863761 ttatggcgat catgttcgcc ttatttttaa ttttgcgccc gcctgttgaa tattaccggc 863821 aatattttgc ccagtggact gccagcaagg tgctttatga tataagagct aagctgtttg 863881 accatataca aaaactgagc cttcgttttt acgcgaatac aagaacaggg gaagtcattt 863941 cccgagtgat taatgatgta gaacaaacaa aggatttcgt catcacaggg ctgatgaata 864001 tatggctcga tatgctgacg attttgattg taatctctat catgctcaca ctggacgtta 864061 aattaacgct gatctctatc gttttattcc cattatacgg aatatcagtg aagtattttt 864121 acggccgttt acgaaagctg acaagggagc gctcacaggc tcttgctcaa gtgcaggggc 864181 atttgcatga acgcattcaa ggcatgcctg tcatcagaag ctttgcgata gaagatcatg 864241 aacaggctca atttaatgag aaaaacggtc atttcttaga taaagccatc cgccacacga 864301 attggaacgc gaaaaccttt gcggtcgtta ataccattac agatttggcg ccgctcatcg 864361 tcatagcgtg cgccgggtat tttgtcatta atggaccgct gacagtcgga acaatggtcg 864421 cgtttgtcgg atatattgac agaatgtaca accctgttag aaggctgatc aattcctcta 864481 caactttgac acagtcaatc gcatcaatgg acagggtgtt tgaatttatt gacgagccct 864541 atgaactcac tgacaaacca aatgcgataa aggccgatca gattcgcgga ggagtggagt 864601 ttcaaaacgt ttcgtttcaa tatgagaagg acaaagaaaa tattcttcat gatgtatcct 864661 taaaagtaaa tagaggagaa actgtagctc tcgtcggcat gagcggagga ggaaaatcaa 864721 cgctcgtcag cctgatccca agattttatg atgtaacaag cggcagactg ctgattgatg 864781 ggacggatat tcgcgattat gaagcaagaa gccttcgcaa ccaggttggt atggtgcttc 864841 aagatacctt tttatttagt gaaacgattc gggaaaatat cgcgatcggc aagcctgatg 864901 ccacacttga agagataatc gaagccgcca aagctgcaaa tgcccatgaa tttatcatga 864961 gttttccaga aggatatgag acccgggtgg gggaacgagg cgttaagctt tcaggcggac 865021 aaaagcagcg gatctcaatt gcgcgggtat tcctgaaaaa tccgccgctc ctcattttag 865081 atgaagctac atcagctctg gatttggaaa gtgagcatta cattcaagaa gcgatggaca 865141 aactggcgaa ggatagaaca acttttgttg tcgcccaccg tttatcgaca atcacccatg 865201 cggataagat tgttgtcatg gaaaacggga caatcattga aatcggaacc catgatgaac 865261 tcatggacta tgagagccaa tacaagcact tatttaccat tcaaaatttg aactaaaaca 865321 tcaatcttat atccttttaa cgaaggatat aagatttttt tgtatataaa aaaacccggc 865381 tgtttaaccg ggttactctt ctgtttctat ttcgcagtct ttcggatgat acgtttgaaa 865441 acttgtgata agtgtttcta aatgttcaag ctgctcgcga tattccacgg cgcttgccat 865501 aatattgagc atgttgtaat caataagctc ctcatccgta ttctgctgat tttttaaaaa 865561 tgactttgtt aaaagctgct tataccggat gccttcttca accgcgtcat catgcggctt 865621 gatttttccg acaaacctca tcaaaatccg ctcgtgccag taaagcaggt aatcaagttc 865681 ttcagtcaat gtttcctgaa actcttccgg catatgatag atctcgtttt ccagacgatg 865741 cagcttcttc aatgtatcaa gcgcccgatt tgcagtaata atggcctgtc tgaacaggac 865801 aagctttctt gatttcacat aagtcgtttt cttaaagtaa cttctttctt ctttatatag 865861 aagatatgtc tgatcaagct tgatcatttt ttctttcagt ttttcaatat cctctttcaa 865921 aatcgaatgc tctgtcgact gccgcatgga caatctgatc cacttcataa tttcttcggt 865981 gttttcgacg gtattatgaa tcagctttgt ttcgtactta ggaggcaaaa acacaaggtt 866041 gacgataaag gaagaaagca cccctaagat gactgtgctt gttctgatca gcgcgaacat 866101 taaaaagtcg tcaccggcag attctaatat cgcaatgact gttacaagag caattgaaat 866161 tgtatgttca attttaagtt tcagcatgat tgtaatgaca ataactgctg ttaacccgat 866221 cataatcggg ctgggtccga aaataaggcc gaacactgtg gcaatcacag ctccgatgat 866281 atttgcttga acctggtcaa taataatgag aaaagagcgg taaatcgacg gctggatcgc 866341 aaatatcgct gcaattccag cgaaaatcgg cgcgggaagc ccgatccacg aagccaaata 866401 aagggcaagt gtaatcgcaa tcccggtttt gaaaatgcgg gcaccaagtt tcattggttt 866461 gtgcgtgcat tcctttctat agtaaattgt gtgacatagc aaatgggcta atccttaaaa 866521 ttcccggtta gtttatttgc taaacaatta agtaatatac agggatcgat acaaatattc 866581 aagctatttt tctagaaaaa gaccaaaatc ttacacgctg tttgattcca taaaaaaaca 866641 ggagctcaaa gctcctgttc aaggtatttg attctagttt tttagatgtt taaatgcatc 866701 ctcgaccgct gtaagcgtgt ctttaatatc ctgctctgta tgtgctgtgg taataaacca 866761 agcttcatac ttagaaggtg ctaaattaat tccgcgttcc agcatcagct tgaaaaacgt 866821 agagaatgtt tctccgtcac tccgttcagc ctgctcgtaa ttttccactt tctcatcaga 866881 gaagtatacc gtgagcgcac cttttaaccg gttgaccgta atggtgatgc cgtgtgtttc 866941 tgcgtgcttc aaaatgcctt cctcaagcat agcgccaagg tgatcaagct tttcatacac 867001 gcctttttct ttgagcactt ccagacaagc gatgcctgat aggatggaag cggggttccc 867061 tgccattgtt cctgcctgat aagcaggccc tagcggagct acctgctcca tgatttcttg 867121 tttgccgcca taggccccaa tcggaagtcc gccgccgata attttcccga gtgctgttaa 867181 atctggtttc acctgtaaga gatcctgcgc gccgccatac ataaagcgga aagccgtaat 867241 gacttcatcg taaataacga gagcccctgc attatgtgtt aattcattta cttgttctaa 867301 gaagccctct ttcggctcca cgataccgaa gttgccgaca atcggttcaa cgagaaccgc 867361 cgcgatttca ctgccccatt tttcaagagc tgctttatag ctatcgatat cattaaatgg 867421 tactgtgatc acttcgtttg caatgctttt cggtacaccg gctgagtctg gtgtgccgag 867481 agtagacggg ccggagcctg cggcgacaag cacaaggtcc gaatgcccgt gatagcagcc 867541 cgcaaattta atgatttttg tccggcctgt atatgcgcga gccacgcgga tggtcgtcat 867601 aacggcttct gtacccgaat tgacgaatct tactttgtcc atagcgggaa tggcttcttt 867661 gagcattttt gcaaatgtaa cctcgtgttt cgttggtgtt ccatacaata caccgttctc 867721 tgctgctttt ttaatcgctt ctgtaatatg cggatgggca tgtcctgtaa taatcggacc 867781 gtacgccgct aaataatcga tgtatttgtt gccgtccaca tcccaaaaat aagcgccgct 867841 tgctttctcc attgcaacag gagaaccgcc gccgactgct ttatatgatc tagacgggct 867901 gtttacaccg ccgacaatgt gctgtaatgc ctcattgtga agttcaattg attttgtatg 867961 caagaataaa aacctcctat atctccatgc gtcctttcta ttgtagcatg cttccgaaca 868021 agaacaatgg cttcgggctt cagattcagc tgagatggtt gtaatctgga caagaattgg 868081 atacgcttaa taaaaaaaca tccggaggta acgtaatgac tatagaaatc ggacaaaaag 868141 cgcctgatct tgagttaaaa ggtgatcatg gggaaacagt aaaattatcg gattataaag 868201 gaaagtacat cgtgctttat ttttatccaa aggacatgac accgggatgt acaactgaag 868261 catgcgattt tcgggacagt cacgaaagct tcgccgaact ggatgccgtc attatcggcg 868321 tcagcccgga cagccaggaa aaacacggaa aatttaaaga gaagcataac cttccatttc 868381 tgcttcttgt tgatgacgag cataagctgg cggaagcatt tgatgtgtgg aagctgaaga 868441 aaaacttcgg aaaagagtat atgggaatcg agcgttccac ttttttaatt gataaagaag 868501 gccggctcat taaagaatgg agaaaagtaa aagtaaagga ccatgtagcc gaagcgcttc 868561 aaaccctcaa agatatgtct gaaaagtaaa tctctatgag cctatgctta cttttaccct 868621 gatatcaatt gacaaattat cgtagaaaga gttacactaa ttataaacat tacaatgtaa 868681 gaattttttt tagaagagag gtgcatgacg gatggctgca catgaactaa aagaagcctt 868741 agaaacgttg aaggaaaccg gagttcgcat tactcctcaa cgtcatgcga ttctggaata 868801 tctcgttaac tctatggctc atccaacagc ggacgatata tataaagctc tggaagggaa 868861 atttcctaac atgagcgtag cgacggtata taacaatttg cgtgtgttcc gggaatcagg 868921 tttggtaaaa gagctcacat acggtgatgc ttccagcaga ttcgattttg tcacatccga 868981 tcactatcac gcgatttgcg aaaactgcgg taaaattgtg gacttccact acccgggcct 869041 tgatgaagtg gagcagctcg ctgcccacgt cacgggcttc aaggtaagcc accaccgttt 869101 agaaatttac ggcgtctgcc aagagtgttc gaaaaaagaa aatcattaaa aataagctga 869161 ccgcacgaaa cggtcagctt attttatttc gacattttct ttttattata agactcatca 869221 aattcttttc cttctaatcc cttatctaaa gtcagcggct ctcggcaatg catgcacata 869281 tcgactactc ctaaaacctt tgtctcttta tcacagcctg gacaaatgac gcgaaccgct 869341 ttagtcgaaa gcattccgat ccaaaagtaa actaccgtgc tgagaccgat ggataaaagc 869401 ccaagtatca taaacaaact agaaagcaaa actgactctt tgaaaaagat cccgatgtac 869461 ataatgataa acccaacgaa aaccaaactt aacgcaaatg ttctgatttt attaattttg 869521 ctggagtatt tcgccatgtc catccccctc tgttttaact atagcacaaa cccgatggga 869581 ttttcttcat gttttcggtt gaactggaat ttacatatgg agagttactg tgaaattgtt 869641 tataatagtt caatgtgttt agaaaaaagg aatttcgttt taaccataga attgaatcaa 869701 atagagaata aaaaaatttg aacaattgca ttggaggaat agtgatggaa aatcttctcc 869761 gtccaattta ccaagaaaga gcaagtcacc ccaatacatt ggctgtcatt atgattgaga 869821 gaagaaacaa aacatcttcc ttaacagata actttgatgc agctttgctg gtgattgtaa 869881 aggatgctga tgagccagtt tttataaagc attatgaatt tgatcatcaa acagcttctt 869941 tgcatgtggt aacagattct cagattcaag aatggatttt gcttggaaca aatagaagaa 870001 tcatagattg gattgtaaat ggcagagtct tgtttgaccg taatgaatac gtagttgaac 870061 tgattgacag gctgaataca tttccgtttg ccgaacgtaa actgaagatc ggactcgaat 870121 acggcaaatt aatcagaagg tatgttgaag ggaaagcttt ttttgaagcc aatcaatttt 870181 tagatgccta caatgccgtt gttcatgcgc tgcatcattt agcacgtatt gaagtaatcg 870241 acagaggatt ccatcccgaa accacggtgt ggagccaagt gcgccagatg gagccccaag 870301 tgtacaaatt atattccgag ctgattgaaa gtcatgagag cctggaaaaa agacttgaat 870361 tattattctt agcaaatgat tttctcatcc attccaaagc cgagatcggt tcggcgcatc 870421 ttttcgaagt aatgaaagaa aaagacattt ggcaattcgg tgagcttctt caacatcatg 870481 acctaaagca ctttacccaa gatcttggcg ttatgcttga ttacttgacg gaaaagggac 870541 ttatcaacgt ctgccagata gaaacgaaag gacaggctgt ctatcaccga ggatattctt 870601 ttaaaaaagg tgttgactct gattcttgac cgtgttatat tattaaacgt cgctgatgcg 870661 cttctgagaa aacaagctca cagcggcggg aaaataaatc aaaaaaacat ttgacaaaag 870721 aaagtcaaaa tgttatatta ataaagtcgc ttcaacaaga agtgaaaatg atctttgaaa 870781 actaaacaag acaaaacgta cctgttaatt cagtttttaa aaaatcgcac agcgatgtgc 870841 gtagtcagtc aaactagggc ctgcacgacg caggtcacac aggtgtcgcc gcaggatgcg 870901 gtgaacttaa cctgtgatcc atttatcgga gagtttgatc ctggctcagg acgaacgctg 870961 gcggcgtgcc taatacatgc aagtcgagcg gacagatggg agcttgctcc ctgatgttag 871021 cggcggacgg gtgagtaaca cgtgggtaac ctgcctgtaa gactgggata actccgggaa 871081 accggggcta ataccggatg gttgtttgaa ccgcatggtt caaacataaa aggtggcttc 871141 ggctaccact tacagatgga cccgcggcgc attagctagt tggtgaggta acggctcacc 871201 aaggcaacga tgcgtagccg acctgagagg gtgatcggcc acactgggac tgagacacgg 871261 cccagactcc tacgggaggc agcagtaggg aatcttccgc aatggacgaa agtctgacgg 871321 agcaacgccg cgtgagtgat gaaggttttc ggatcgtaaa gctctgttgt tagggaagaa 871381 caagtaccgt tcgaataggg cggtaccttg acggtaccta accagaaagc cacggctaac 871441 tacgtgccag cagccgcggt aatacgtagg tggcaagcgt tgtccggaat tattgggcgt 871501 aaagggctcg caggcggttt cttaagtctg atgtgaaagc ccccggctca accggggagg 871561 gtcattggaa actggggaac ttgagtgcag aagaggagag tggaattcca cgtgtagcgg 871621 tgaaatgcgt agagatgtgg aggaacacca gtggcgaagg cgactctctg gtctgtaact 871681 gacgctgagg agcgaaagcg tggggagcga acaggattag ataccctggt agtccacgcc 871741 gtaaacgatg agtgctaagt gttagggggt ttccgcccct tagtgctgca gctaacgcat 871801 taagcactcc gcctggggag tacggtcgca agactgaaac tcaaaggaat tgacgggggc 871861 ccgcacaagc ggtggagcat gtggtttaat tcgaagcaac gcgaagaacc ttaccaggtc 871921 ttgacatcct ctgacaatcc tagagatagg acgtcccctt cgggggcaga gtgacaggtg 871981 gtgcatggtt gtcgtcagct cgtgtcgtga gatgttgggt taagtcccgc aacgagcgca 872041 acccttgatc ttagttgcca gcattcagtt gggcactcta aggtgactgc cggtgacaaa 872101 ccggaggaag gtggggatga cgtcaaatca tcatgcccct tatgacctgg gctacacacg 872161 tgctacaatg gacagaacaa agggcagcga aaccgcgagg ttaagccaat cccacaaatc 872221 tgttctcagt tcggatcgca gtctgcaact cgactgcgtg aagctggaat cgctagtaat 872281 cgcggatcag catgccgcgg tgaatacgtt cccgggcctt gtacacaccg cccgtcacac 872341 cacgagagtt tgtaacaccc gaagtcggtg aggtaacctt ttaggagcca gccgccgaag 872401 gtgggacaga tgattggggt gaagtcgtaa caaggtagcc gtatcggaag gtgcggctgg 872461 atcacctcct ttctaaggat attatacgga atataagacc ttgggtctta taaacagaac 872521 gttccctgtc ttgtttagtt ttgaaggatc attccttcga aacgtgttct ttgaaaacta 872581 gataacagta gacatcacat tcaattagta atacaagata tcacatagtg attcttttta 872641 acggttaagt tagaaagggc gcacggtgga tgccttggca ctaggagccg atgaaggacg 872701 ggacgaacac cgatatgctt cggggagctg taagcaagct ttgatccgga gatttccgaa 872761 tggggaaacc caccactcgt aatggagtgg tatccatatc tgaattcata ggatatgaga 872821 aggcagaccc ggggaactga aacatctaag tacccggagg aagagaaagc aaatgcgatt 872881 ccctgagtag cggcgagcga aacgggatta gcccaaacca agaggcttgc ctcttggggt 872941 tgtaggacac tctgtacgga gttacaaaag aacgaggtag atgaagaggt ctggaaaggc 873001 ccgccatagg aggtaacagc cctgtagtca aaacttcgtt ctctcctgag tggatcctga 873061 gtacggcgga acacgtgaaa ttccgtcgga atccgggagg accatctccc aaggctaaat 873121 actccctagt gaccgatagt gaaccagtac cgtgagggaa aggtgaaaag caccccggaa 873181 ggggagtgaa agagatcctg aaaccgtgtg cctacaagta gtcagagccc gttaacgggt 873241 gatggcgtgc cttttgtaga atgaaccggc gagttacgat cccgtgcaag gttaagcaga 873301 agatgcggag ccgcagcgaa agcgagtctg aatagggcgc atgagtacgt ggtcgtagac 873361 ccgaaaccag gtgatctacc catgtccagg gtgaagttca ggtaacactg aatggaggcc 873421 cgaacccacg cacgttgaaa agtgcgggga tgaggtgtgg gtaggggtga aatgccaatc 873481 gaacctggag atagctggtt ctctccgaaa tagctttagg gctagcctca aggtaagagt 873541 cttggaggta gagcactgat tggactaggg gcccctaccg ggttaccgaa ttcagtcaaa 873601 ctccgaatgc caatgactta tccttgggag tcagactgcg agtgataaga tccgtagtcg 873661 aaagggaaac agcccagacc gccagctaag gtcccaaagt atacgttaag tggaaaagga 873721 tgtggagttg cttagacaac caggatgttg gcttagaagc agccaccatt taaagagtgc 873781 gtaatagctc actggtcgag tgactctgcg ccgaaaatgt accggggcta aacgtatcac 873841 cgaagctgcg gactgttctt cgaacagtgg taggagagcg ttctaagggc tgtgaagcca 873901 gaccggaagg actggtggag cgcttagaag tgagaatgcc ggtatgagta gcgaaagagg 873961 ggtgagaatc ccctccaccg aatgcctaag gtttcctgag gaaggctcgt ccgctcaggg 874021 ttagtcggga cctaagccga ggccgaaagg cgtaggcgat ggacaacagg ttgatattcc 874081 tgtaccacct cctcaccatt tgagcaatgg ggggacgcag gaggataggg taagcgcggt 874141 attggatatc cgcgtccaag cagttaggct gggaaatagg caaatccgtt tcccataagg 874201 ctgagctgtg atggcgagcg aaatatagta gcgaagttcc tgattccaca ctgccaagaa 874261 aagcctctag cgaggtgaga ggtgcccgta ccgcaaaccg acacaggtag gcgaggagag 874321 aatcctaagg tgatcgagag aactctcgtt aaggaactcg gcaaaatgac cccgtaactt 874381 cgggagaagg ggtgctctgt tagggtgcaa gcccgagaga gccgcagtga ataggcccag 874441 gcgactgttt agcaaaaaca caggtctctg cgaagccgta aggcgaagta taggggctga 874501 cgcctgcccg gtgctggaag gttaagagga gcgcttagcg taagcgaagg tgcgaattga 874561 agccccagta aacggcggcc gtaactataa cggtcctaag gtagcgaaat tccttgtcgg 874621 gtaagttccg acccgcacga aaggcgcaac gatctgggca ctgtctcaac gagagactcg 874681 gtgaaattat agtacctgtg aagatgcagg ttacccgcga caggacggaa agaccccgtg 874741 gagctttact gcagcctgat attgaatgtt ggtacagctt gtacaggata ggtaggagcc 874801 ttggaaaccg gagcgccagc ttcggtggag gcatcggtgg gatactaccc tggctgtatt 874861 gaccttctaa cccgccgccc ttatcgggcg gggagacagt gtcaggtggg cagtttgact 874921 ggggcggtcg cctcctaaaa ggtaacggag gcgcccaaag gttccctcag aatggttgga 874981 aatcattcgc agagtgtaaa ggcacaaggg agcttgactg cgagacctac aagtcgagca 875041 gggacgaaag tcgggcttag tgatccggtg gttccgcatg gaagggccat cgctcaacgg 875101 ataaaagcta ccccggggat aacaggctta tctcccccaa gagtccacat cgacggggag 875161 gtttggcacc tcgatgtcgg ctcatcgcat cctggggctg tagtcggtcc caagggttgg 875221 gctgttcgcc cattaaagcg gtacgcgagc tgggttcaga acgtcgtgag acagttcggt 875281 ccctatccgt cgcgggcgca ggaaatttga gaggagctgt ccttagtacg agaggaccgg 875341 gatggacgca ccgctggtgt accagttgtt ctgccaaggg catcgctggg tagctatgtg 875401 cggacgggat aagtgctgaa agcatctaag catgaagccc ccctcaagat gagatttccc 875461 attccgcaag gaagtaagat ccctgaaaga tgatcaggtt gataggtctg aggtggaagt 875521 gtggcgacac atggagctga cagatactaa tcgatcgagg gcttaaccat atttttgaat 875581 gatgtcacac ctgttatcta gttttgagag aataagtttt tcaaaaaaac acttgatttt 875641 ctcaagaata catagtataa tgttaaatgt cactgaaatt gtctggtgat gatggcgaag 875701 aggtcacacc cgttcccatg ccgaacacgg aagttaagct cttcagcgcc gatggtagtc 875761 gggggtttcc ccctgtgaga gtaggacatc gccaggcaga cttcattccg cagtagctca 875821 gtggtagagc tatcggctgt taaccgatcg gtcgtaggtt cgaatcctac ctgcggagcc 875881 attattggag agctgtccga gtggtcgaag gagcacgatt ggaaatcgtg taggcggtca 875941 actccgtctc aagggttcga atcccttgct ctccgccact gatacttata cataattaca 876001 attgaaagtc tgggcccgtt ggtcaagcgg ttaagacacc gccctttcac ggcggtaaca 876061 cgggttcgaa tcccgtacgg gtcattatat gatggaggat tagctcagct gggagagcat 876121 ctgccttaca agcagagggt cggcggttcg agcccgtcat cctccaccat tatatcatcg 876181 cggggtggag cagttcggta gctcgtcggg ctcataaccc gaaggtcgca ggttcaaatc 876241 ctgcccccgc aaccaaattt taaaatggtc cggtagttca gttggttaga atgcctgcct 876301 gtcacgcagg aggtcgcggg ttcgagtccc gtccggaccg ccatttgaat acttaggctc 876361 ggtagctcag ttggtagagc aacggactga aaatccgtgt gtcggcggtt cgattccgtc 876421 ccgagccacc acctatgccg gtgtagctca attggtagag caactgactt gtaatcagta 876481 ggttgggggt tcaagtcctc ttgccggcac tgttttttca aaatttaatg tggaggggta 876541 gcgaagtggc taaacgcggc ggactgtaaa tccgctccct cagggttcgg cagttcgaat 876601 ctgcccccct ccaccattta taggggcata gtttaacggt agaacagagg tctccaaaac 876661 ctccggtgtg ggttcgattc ctactgcccc tgccaaattt atgacatctt gagattatgg 876721 cggttgtggc gaagtggtta acgcaccaga ttgtggctct ggcactcgtg ggttcgattc 876781 ccatcaatcg ccccatatta tcattgggct atagccaagc ggtaaggcaa cggactttga 876841 ctccgtcatg cgttggttcg aatccagcta gcccagtctc actttttata tcaactgcat 876901 ataatgtatt aagtccatta aaaatgcgga agtagttcag tggtagaaca ccaccttgcc 876961 aaggtggggg tcgcgggttc gaatcccgtc ttccgctcca attacggcgg catagccaag 877021 tggtaaggca gaggtctgca aaacctttat ccccggttcg aatccgggtg tcgccttctt 877081 attgccgggg tggtggaatt ggcagacaca caggacttaa aatcctgcgg taggtgacta 877141 ccgtgccggt tcaagtccgg ccctcggcac caattttact tacatggtaa gttgaattgg 877201 tgtttgtgtt ttatcattat aactaatcat attaatgatc tacataagta gatcattttt 877261 ttaatgcttt gatttatcat aacaagttaa gttccgaggc ctattataaa gcggctgtat 877321 agctagtctt tcaacacttt tattttatat ttccataaaa acttttttga aatacgttga 877381 cactttatga gatccatgat atatttatat tcgtcggtta gatacgacgt aaaacttgcc 877441 ggtgtggcgg aattggcaga cgcgcacgac tcaaaatcgt gttccttctg gagtgtcggt 877501 tcgaccccga ccaccggtat actgaaaaac ccgtttctta acagaaacgg gtttttattt 877561 tttattaaag aaaaggagcc tcggctcctt tttatactta ctcagcgtat tggtctagga 877621 tctcttctag cacctcttct agctcttctg tatcttcaag ctctgattgg ctgaaacgga 877681 cgcgtacaag ctgttctccg tcattataca tctcttccaa ccaccctcgg agtcctcttg 877741 ctctgcggtc gacttcgaaa atgatttcca aaccgtcttc gtctaaaagg aaaatgagct 877801 ctaattcatc aagcatctga cgataatatc cggaagtcgg aacgaattcg aattcttgaa 877861 cgaacggaag acgacgctgg aagtagggcg cttgttcgca gtctgcttcg ttaagacgga 877921 agcccaggtt ttcgattgct tcaagcacat tttcaatcca agggtgcgct tcaacgaaaa 877981 tgcggtcatg atcggattta tcgataccgc cttgaatgtc aaggtctgtc accacggcaa 878041 cctctacttt ccctacagtg atcggcgtat ctagaggcag agtgaatgtg aacggaaatt 878101 gatgctcttc accaggctgt atggtaaatg aaccagtgac ccggaaagaa tgaattgtag 878161 cgtatttccg gtgctcttca tcgtctttta caatgacata ccgtgtgcta agctgtaaat 878221 cgatataacg gatgtcctga gcgatttttc cgcctttgac atgtaccgtt ccctgtactt 878281 cttctcctgg aaaatatgcg tctttttcta aaattgtatc tacttttgca gctccaattc 878341 cggcacttgc cgcaagcttc ttaaaaaatg acatgttaga tcttcccctt tttctttttt 878401 ctcaacagat atacgtaaga aggaggaaaa aagattcgtt tgattcatac ttttttccta 878461 ttattcgtct cggcctaggg acagactaag aataatattg aaaataaagg agtcgatgga 878521 agtgaataaa gaaagtttgg ttgcagatga attacacaga atgtttttgg ctggtgagct 878581 gcaaatcaca gtagaggagg atataaacaa tatttccgaa aggctgagaa acggcgatct 878641 cagtttagac cgattaagcg gtgaagacgt gtttataaaa gaaacggtaa atgaggcttt 878701 aagaagagtg gagcaataaa aaagagacgg catctcatct ttgagatccc gtctcttttt 878761 gtggtctttg ctgtaagata aaagcgaatc gatttggaat tgctcacccg agccacccct 878821 tttctaacag aagatctgac agttcatcat ggagataaac agctgtatct aattgatcat 878881 gcaatgctct tctgatgtgg ggattttcgg ttgctgttgt tgcgacagtg tatttgttaa 878941 tgctggtttt tattgttgtt aacaaatcaa gaatatcttt gggacaaaga ctttgttcaa 879001 tgggaaacca cctcctttgt ttttttagca gctcctgata agaaagtatt tgactttgtt 879061 tcttgcttct atacaaaatg ctataataag caacaaattt tgttgggggg tgtgatgatg 879121 aagcagatta ttgcgatggg gggcgggggt ttttcgatgg agccggataa tttgtccctc 879181 gatcaatata tcctcaatca atcaaaacga gagcagcctc gtatttgttt tttgccgacg 879241 gcgagcggag attcccaaaa ctatattcag cggttttatc atgcatttca aacattggat 879301 tgcgtgccgt ctcatttatc tttgtttaag ccaccatcat cagatttagt ttcttttgtt 879361 atggaaatgg acgtgattta tgttggcggg ggaaatacgc ggaatttact tgtgttatgg 879421 aaagagtggg ggctggacca tattctcagg gaagcatgga agaacggtgt ggttgtagct 879481 ggaataagtg ccggtgcgat ctgctggttt gaagaagggg tgacagattc agccggaccg 879541 ctgacaagtt tgaaaagttt aggttttttg caagggagct tttgtcccca ttatgacggg 879601 gaaaaggatc ggagaccggc ataccaccag ctgatatcta acaagttctt atgcagtggc 879661 tatgcagcgg atgatggggc tgctctccat ttcataaatg atcagctgtt tcagactgtg 879721 agttcaaggt cgggtgcaaa ggcatatcgg gtgatgatgg ctgaacatga aatagctgaa 879781 atcccgttgc cggtcaaata tttagggtga aattggctga atattatcta tattcctctt 879841 tttttcagat tgattttatg ataagatgag tgcgaaatca atagttactg ggggtgcccg 879901 ctttcgggct gagagagaag gcaagcttct taaccctttg gacctgatct ggttcgtacc 879961 agcgtgggga agtagaggaa ttgtttttgt tattgtcttg ctgggcaata atatgtttct 880021 ttctgactgt aaccgggttc atttatatga atccggtttt ttgtgctggt tatgggcttg 880081 attttgtcct ttcaaacgta gaaaggggaa ggaaaagtaa tgcaaaacaa ttcagtgcag 880141 caagccaaca tttccattat gtcaagtttt tcaggcagca agaaggtata cgtggagggt 880201 tcttcttcgg acatccaagt gccgatgagg gagattgcat tgagtccgac gacgggatcg 880261 ttcggcgaag aggaaaacgc gcctgtgcgt gtctatgata caagcggacc gtatacggac 880321 cctgaagtaa ccattaatat tcaagaagga ttaaagccgc tccgccaaaa atggatcaca 880381 gagcgcggtg acgtggaaga gtatgaaggt cgggctataa aaccagaaga taacggttat 880441 aaaaaagcaa aaccaaacgt aagctatcca ggattaaagc ggaaaccgct gagggcgaag 880501 gcaggtcaaa atgtcacaca aatgcactat gcaaaaaagg ggatcattac acctgagatg 880561 gaatttatcg ccattcgtga gcatgtgtct cctgaattcg tcagagacga ggtagccagc 880621 ggccgggcga ttattccttc aaacattaat caccctgaaa gtgagccaat gattatcggc 880681 cggaattttc atgtgaagat taatgcaaat atcgggaatt cagcggttac gtcatccatt 880741 gaagaagaag tggaaaaaat gacgtgggcc atccgctggg gagcggatac gatgatggat 880801 ctctctaccg gaaaagatat tcatacgacg cgtgaatgga ttatccgcaa ttgccccgtg 880861 cctgtgggaa ctgttccgat ttatcaggcg cttgaaaaag taaacggcgt agctgaggat 880921 ttaacgtggg agatttatcg tgatacgcta atcgagcagg cagagcaggg agtggattat 880981 tttacgattc acgcgggtgt tttgcttagg tatgtaccgc tgactgccaa acggacaact 881041 ggtatcgtgt cacgcggggg agcgattatg gcgcagtggt gtctggctca tcatcaagaa 881101 agctttttat acacacattt tgaagaaata tgtgagatta tgaaaatgta tgatattgct 881161 ttctctcttg gggatggttt gcgtcccgga tcaattgctg atgccaatga cgaagcgcag 881221 tttgctgaat tagagacgct tggagagctg acgcaaattg cctggaagca tgatgttcag 881281 gtgatgattg agggtcctgg acatgttccg atgcataaaa tcaaagagaa cgtcgataaa 881341 caaatggaca tttgtaaaga agcgcctttt tacacattgg ggccgttgac aacggatatt 881401 gctccgggat atgaccatat tacttcagcg atcggagcgg cgatgatcgg ttggtacggg 881461 acagcaatgc tttgttatgt aacgccgaag gagcatttgg ggctgccaaa ccgtgatgat 881521 gttcgtgaag gagtcattac atataagatc gctgcgcacg ctgcggacct tgcaaaaggg 881581 catcccggag cgcaaatccg ggatgatgcg ttatcgaaag cccgttttga attccgctgg 881641 cgggatcagt ttaatttatc tcttgatccg gagagagccc ttgaatacca tgatgaaacc 881701 ctgcctgctg aaggagcaaa aaccgctcac ttttgttcca tgtgcggtcc gaaattttgc 881761 agcatgagaa tttcacagga tattcgggat tatgcgaaga aaaacgatct cagtgaagca 881821 gaagccataa ataaaggatt aaaagaaaaa gcaaaagagt ttgtcgatac gggaagcaat 881881 ttatatcaat aaaaaaaatg aagatggaga atgctccatc ttcatttttt tagaaaaaca 881941 gagagcgtcg aagcggagga atactctgtt caaagcggaa aacattttct ggatcatatg 882001 tcgttttgac acggcggagt cgttcaacgt tttcgccgta atatgttctt ggccagtttc 882061 tgatttcgat atctggccaa tttacgtagt ctcccatcgt ttctttcgaa agggacgttc 882121 tcagcccctc aatccagcgg acattttgtc ttttttctcc aggggatgtc cagtttgtta 882181 agtattcctg ggcgatgatt gcgtcacgat aataaaatgc cgtttggtcg ggagcgaccc 882241 gtccggctgc cccgccgagt gcttgctgcc agacactggc gttttgattc ggagcgtgct 882301 ctaaaaagtg ttttattgtt gagatcgcac gttctgataa tggcttttca atgaaagagc 882361 cggagcgttt cattttttga ggctgattgc ctcccgggct gttaaaaaag gttaccgctt 882421 caatgaatgg cgttgttttt accattccgc ttgtcggact tcctgctttc aataaaggct 882481 ttaacagttt ttttaactct gtttttggcc cgacaaattg gccgagggct tctatgcggt 882541 ttacttcttt aggccaaaac tctattgatg atgtaagccg gtcatctgta tacggggccc 882601 agttctgcca cgtgttatat acttcctcaa aatcatccca tccccatgta atagaaaaaa 882661 tcgacacttg agagatgggc actgctttaa atgtcatgga ggtgactatg ccgaaattgc 882721 ctcctccgcc tccctgagac gcccaaaata agtctggatg atttgaacag ctgactgtaa 882781 tcagatcagc gccctctttt tcgtctgcta cgatcatctc aagctgcacg aggctgtcgc 882841 aagtaagacc ggcagccctt gttaaaagtc caattccccc tccgagagtt aaacctgtga 882901 gccctacatt agcaatggtg cctgcgggaa gcgtcaggcc gtattgccag agtgtccgat 882961 agacttctcc caattcagcc cccgcttcaa tataggccag ctttttatcc tgattcacag 883021 ttattttttt catctcgctt aaatcaataa caagaccgtt atttaaaagg gaaaagttct 883081 catagctgtg tctgccgcct ctaatacgga aaggcacacg gttttcacgc gcccatttca 883141 gcgcattgag tgcatcctgt ttgttttggc aaaacacaat gatgtcagga tacctttcta 883201 agcttaggtt aatattggtt cttgcttcgt tatagtccgg atcatcccgt gtcacgatac 883261 gtccggtcaa ttttgtcttt tccacactcc cacatctctt tctctcgtat tctagtttct 883321 ctagcttatg cgtcagggga aaagagtgta taaggaaaaa gcggggatgc aatctgatac 883381 agtgtcaaca ccctcaaaaa atagttgaca ggtcggtatt gtatgaatta acatggtcag 883441 tacaaatttt tcaaatttat cgcgctgatc ggaacaccga aggctcttat cgtttagata 883501 agggcctttt ttgtatgaaa aaggggggat tattgatggg agtcaaaaaa gaaaagggga 883561 gaaaacgatt caggaagcga aaaacctacg ggaatcagat tttgccgctt gagctgctga 883621 ttgaaaaaaa caaacgagag attataaaca gcgcggaact catggaagaa atttatatga 883681 agattgatga gaagcatacg caatgtgtaa ctaaatataa aaaaacccgc tgactacaac 883741 gggtttttgc atttctccat taagaatctt ttttaatcgg caatccaagg ccttctgcca 883801 cgcgttttcc gtattcagga tccgctttgt agaagtgctc gatttggcgc agcttgattt 883861 cttctttttc taccggcttc atggcattaa cgatattttc aacaaggcgg gtacgttcat 883921 cttcactcat taaacgatac agatcgccgg cttgagtgta gtgatcgtag tgatcgtagc 883981 ttacgctgtc agcgatacct tgtaccggat atgctgcttg cttatcctca ggtgactctt 884041 ttggaccgcc gaagctgtta ggctcgtaat acacagatcc gccgccgtta tcatcaaaac 884101 gcatttgccc atcacgctga taattgttta ctttgttgcg tgcgcggttg attggcagcg 884161 cttgatggtt tgcaccgaca cggtagcggt gtgcatcatg ataagcaaaa agtcgacctt 884221 gaagcatttt atccggtgaa acatcaatac caggcacgag ggttccaggt gaaaatgtcg 884281 cttgttctac ctctgcaaag tagttttccg gatttctgtc tagaaccatg cgtccgacct 884341 cgattaacgg gtagtctttt tgagaccaaa cttttgtgac atcaaacgga tcgaaacggt 884401 acgtatttgc atcttctaaa ggcatgattt gcacatatag tttccatgca ggataatcac 884461 cgttttcgat tgcgttgaaa aggtcttctg tatggtaatc agggttttca ccggcaattt 884521 ttgctgccgt attgacatca aggtttttca cgccttgttc tgttttaaag tgatatttaa 884581 tccatacgcc ttcgccttcg gcatttgtcc atttgaatgt atggcttccg aagccgtgca 884641 tgtggcgaag tgtcgcagga attccgcggt cagacatcag gattgtcact tggtgcagtg 884701 actctggtga aagtgaccag aaatcccata cagccgtagg gtttttcagg tgtgtttttg 884761 gatctctttt ttgtgtatgg atgaaatcag ggaacttaat cgcatcgcgg ataaagaata 884821 caggcgtatt gttgccgacg atgtcgtagt ttccttcttc agtataaaat ttaacagcaa 884881 atccgcgcgg gtcgcgaact gtgtcagcag agccaagttc accggcaact gttgagaaac 884941 ggatgaacaa cggtgtgcgt ttgccgactt cagaaaggaa agcggctttc gtgtattttg 885001 ttacgtcgtt tgtcacttca aaatatccgt gtgcgcctgc tcctttggcg tgaacaacac 885061 gttcaggaac acgttctcgg ttgaaatggg ccaatttttc gagtaaatgt acatcttgaa 885121 ttaaagttgg tccgcgagaa ccggcagtca ttgagttttg attatctcca accggagcgc 885181 cccagctagt tgtcagttta tttgaactca tgttatcacc tcttggaatt tataagaaca 885241 taatatcatc tctaagtaaa aagtcaatat tattttataa ttattataaa atagttatct 885301 ctattaatcg atatatagta tcgaaattgt tgaaaaacct tgttgtaaca gctttttatg 885361 acacttaata atttttggag aaataatttt tccttctcta tttgcgaaac aagcagagta 885421 agtgataaac aaggatatca aaaatcgtat ttaaaaaaga gttgacatat cggaataatt 885481 tgaattaaca tgttattcaa acaaaaaaac aattgggcag ctgatcggac cgccgaaggc 885541 tctcatctct acaagaacag agatgggggc ctttttgttt tttttgaagg cggggttggc 885601 agaaagagag ggataaaagt ggctgtgacc atcagcatca aagaaaaggc atttgttcaa 885661 gaaggccgca aaaacacggt cttagaaaac atagaattat caatcgcacc aggcgaattt 885721 ctaacgctta tcggaccgag cgggtgcgga aaaagcaccc tgttaaagat tattgcaggg 885781 cttgattctg aatatgacgg gagtgtggaa attaacggcc gcagcgtaac agctccgggt 885841 attcagcaag gatttatttt tcaggaacac cgcctctttc cttggctgac tgttgagcag 885901 aatattgcag ccgacttgaa tttgaaggac ccaaaagtca aacaaaaggt ggatgaactg 885961 atcgagattg tcagattgaa aggatcggaa aaagcatatc cgcgcgagct gtcaggcggc 886021 atgtcacaaa gagtagccat cgcccgggcc ctgctgcggg agcctgaggt gctgctttta 886081 gatgaaccgt ttggtgcact cgacgctttt acaagaaaac acctgcagga cgtgctgctg 886141 gatatatgga ggaagaaaaa aacaacgatg attctcgtga ctcatgatat agatgaatct 886201 gtttatttag gaaatgagct tgcgatcctt aaggccaaac cggggaaaat ccataagctg 886261 atgcccattc acctggcgta tccgcgaaac cggacgactc cggatttcca agcgatcaga 886321 cagagagtgc tgtcggaatt cgagaaaaca gaagatttgg agtacgcaga aggatcaggg 886381 atatagaaag ggcggaagcg gaaatgaaaa aaggactcat tgtattggtt gccgttattt 886441 ttctgctcgc aggctgtgga gcaaatggag ccagcggtga ccacaaacaa ttgaaggaaa 886501 ttcgtattgg tattcagcaa agcttaagcc cccttttgat tgcaaaagaa aaaggctggt 886561 tcgaagatgc atttgaaaaa gaaggcatca aagtgaaatg ggtggagttt caaagcggtc 886621 cgccccaatt tgaaggcctt gcggcagaca aacttgattt ttctcaagtc ggtaattcgc 886681 ctgtgatcgc tggacaggcg gcaggcattg actttaaaga aatcggtttg tctcaggacg 886741 gcttgaaagc aaacggcatc cttgtcaatc aaaacagcgg cattcaagac gttaagggct 886801 taaaggggaa gaaaattgca gtcgccaaag gcagcagcgg gtttgatttt ttgtataaag 886861 cgcttgatca agtggggttg tcagctaacg atgtgacaat tattcagctt cagcctgatg 886921 aagcagcttc cgcatttgaa aacggatctg ttgatgcctg gtccatttgg gagccgtact 886981 tgtccttaga aacaatgaaa cacggagcaa aaatccttgt gaacggagaa agcacagatt 887041 tatattcacc gggttttact ttagtaagaa caaagttttc agaagagcat ccagacgaag 887101 tggtccgttt tctgaaggtg tttaataaag ccgttgtatg gcaaaaggaa catctggatg 887161 aagcagcgga cttatattct gacattaaag atctcgataa aaaggtcgtc gaaaatgtgc 887221 tgaaaaatac tgagccactt aatgagatca tcagtgacga cattgtgaaa gcacagcagg 887281 aaacagcaga ttttcaattt cgaacaaagg cgatagataa gaagattgat gtgaaggatg 887341 ttgtcgataa cacttttatc aaaaaagcat tagaggagca ttcctcagga ggtgatcaat 887401 gatgaaagca gaggctgcgg gctcgctgcc caaaacgaat gcggaagcgg tgcgaaaaaa 887461 gcccggaagg aagagatacg gctggatgaa ggggctttta ctgcccgctg tcatcattgc 887521 catctggcag gtcatcggcg ggctgggggt tgtgtccgct acagtgctgc ctacacctgt 887581 tacgattgtt ctgaccttta aggagcttat tttgtccggc gaactgttcg gccatctgca 887641 aatcagcatt tatcgggcgg cacttggttt tttgcttggc gcggggcttg gattgatgat 887701 cgggattttg gccggatttt ccaaacggac ggagctgtat cttgatccgt cgttgcaaat 887761 gcttagaacc gtacctcatc tggccgtcac gccgctgttt attttatggt tcggatttga 887821 cgaagtatct aaaattttgc tgattgcgct cggtgccttc tttcctgtct atatcaatac 887881 gtttaacggc atccgcgggg ttgacgcgaa gctgtttgaa gtcgcccggg tgcttgaatt 887941 taaatggcat cagcagatat ccaaagtgat attgccggca gccctgccca atatattgct 888001 aggcattcgc ttatcgctcg gcattgcatg gctcgggctc gttgtggcag agctgatggg 888061 ctcaagctcg ggagtcggct atatgatcat ggatgcgaga cagttttcac aaacgaataa 888121 agtctttgca gggattatca tttttgcagt ggttggaaag ctgacggatt ccttcgtcag 888181 gctgcttgaa cgaaagctgt taaagtggag aaacagctac gaaggataaa agatataaag 888241 gggagatgaa tatggaaatt ctttggttta taccgactca tggagacgcg agatatttag 888301 gatctgaaag tgatggacgg actgcggatc atctttactt taaacaagtc gcgcaggcgg 888361 cagacaggct gggatataca ggagttcttc tgccaacggg aagatcgtgc gaggacccgt 888421 ggcttacagc gtcggcactg gcaggagaaa caaaggactt aaagttttta gtcgcggtaa 888481 gacctggttt aatgcagcct tctctggcag ccagaatgac atccacccta gaccgcattt 888541 cagacggccg gctgctgatc aacgttgtgg cagggggcga tccgtatgag ctggcaggcg 888601 atggcctgtt tatcagccat gatgagcgct acgaggcaac agacgaattt ttaaccgttt 888661 ggcggagact tttgcaggga gaaacggttt cctatgaagg aaagcatata aaagtggaaa 888721 acagcaatct gcttttcccg ccgcagcaag agccgcatcc gcccatctat ttcggtggtt 888781 cgtcacaggc tggaattgaa gctgccgcaa agcatacaga cgtgtacttg acatggggtg 888841 agccgcctga acaagtaaaa gaaaagatag aaagagtcaa aaagcaagcg gcaaaagaag 888901 ggagatccgt tcgatttggc attaggctgc atgtcattgc ccgtgaaact gaacaagagg 888961 catgggaagc ggcagagcgc ttgatcagcc acttggatga tgacaccatt gccaaagcgc 889021 aggcagcttt gagccgttac gactcttcag gccagcagcg gatggccgtc cttcatcaag 889081 gcgatcggac gaagcttgaa atcagcccga atctgtgggc ggggatcggc ctggtcagag 889141 gaggggcagg aacagctctt gtcggtgatc cgcagacgat tgccgaccgg atagcggagt 889201 accaggcact cggcatagaa tcgtttatat tctccggcta tccgcattta gaagaagcgt 889261 attattttgc agagcttgta tttccgcttt tgccgtttga aaatgatcgg acgagaaagc 889321 ttcagaacaa aaggggagaa gcggtaggaa acacttattt tgtcaaagag aaaaatgcat 889381 gagtttaact aaaatacagc cccccgaaca tggtatgata ttcaaaaaaa gggggctttt 889441 tttctgaaaa cattgagaag cgcggcagtc atttgcctca tagctatgct gtcagcatgc 889501 ggacattcaa aacagatgga aatcaaagcg gcggacatat cagatcttga aaaaaacaga 889561 atggatgtcg cagcttcaca ggcattcact gccgaagccg tcaatatcgg tgaaggtatt 889621 tcttcagctg acatgtacat cgaacattat caaaagggaa agcttgttga gaggtttgga 889681 ccggttcgtg cagattattc agaggaaaaa actgatacca tacaatttgt ttattttgag 889741 aatgaagagg gggaaggaaa gaataaacat accaccattc attttggcat tgtggataaa 889801 cagggaacta tagcggctga ttcatcggtg aaacgcgacg atagcacaac acaggaaatg 889861 actcagaata tttcatcgcc ggaaccgatt actttcgaga agcctgcttt gatcggcagc 889921 agtattagag ggactgacga gacaatgcac acctctgaac ataaaaaaga gctcattaag 889981 catcaagatg cgttactgta ttatgtggaa ttgcatcatt agaatgggcg gcttcaggcc 890041 gtctgtttta caaagcggta tgcttgcttt tttgaatggt gaatgataca ttttaaatcg 890101 taacaatttc gatttaaagg gaggctatgt gacttggcta aaaaatcaaa agtggcaaaa 890161 gagttaaaac gccaacagct tgttgagcaa tacgctggta ttagacgcga gttgaaggaa 890221 aaaggagatt acgaggcact cagcaagctg ccaagagatt cagcaccggg aaggcttcac 890281 aaccgctgca tggtaacggg gcgcccgaga gcatatatga ggaagtttaa aatgtccaga 890341 atcgctttca gggagctggc ccataaaggc cagattcccg gtgtgaaaaa agcaagctgg 890401 taagaaaaaa ctccggccga ttacagcgcg ccggagtttt tttcgttttt cttgaaagag 890461 atgacgtagg aaaggtgctg gatgatcatg atgataaaca caataataat agggaaaaac 890521 ggaatgcgcg attgaaatag cggataaaaa atgagaagaa ccgctgcggc aggcagcgag 890581 aagtagacag cgatatatga cgcgcgacat gcttttgccg tcatcatctg ctctctttca 890641 tcctgctctt caaactcatc aggcagaagt agctgctttc tggcagggcg gctttttttc 890701 tgtaagtaca aataaaccgc agacgccgca acaaacagaa taaagggagt gaggtttaaa 890761 tcaaatacca tcccgccgct ctttgtgccg aaaaaagatg ctatgccttc tgaggcttca 890821 aagtatgaaa tcagcgccca gcatgcaagg ccaaataaaa caaggtgaaa agctgctttt 890881 gttttcatgc tcatcttagt tttcctcctc taaccaaaag acatcctcca ttttcatgga 890941 gaaggctttg cagattttca gtgctaacag cagtgaggga acataatcgc ctttttcaat 891001 cgctgccaca gtctgtcttg tgacgccgac cgtttctccg agtttttcct gagaatagcc 891061 gaagcgtgcc ctcagctctt ttactttatt tttcatcatg acgtctgtcc ccttcacaat 891121 ctcgattgat tatattgtat agtatactta acattatgta aatggaactt aacaacttta 891181 caaaaagata actttttttc gacaaaattt ttatattccc ttgacgaaaa ataaataaac 891241 atgtaatata aaaaaagtca gagcggtact gttgctgaca atcacaaatg cgggtgtagt 891301 ttagtggtaa aacctcagcc ttccaagctg atgtcgtgag ttcgattctc atcacccgct 891361 ccatacatac gttattaacg cagtgtttcg tttctcagat aaacgaagta ttgcgttttt 891421 ttatgtgaaa aagaacacgg tattcgtgtt cttttacgta agccaatgta ctgtatgggt 891481 gccgccgtga atttgttcaa acattttcgt taatgatgat aagaggttaa cagcgctgct 891541 tttctcaatc gatggcggga aaaaaatgat ttgcagcata ttcttagtct cgtttgaaac 891601 gggatagtgg ttgacgctgt ttttgaaatc gccaaaaatg ccgttttcat cagagaaaag 891661 cagtatgttt tctttttctc ccaatgagat ccggaccggc tcatgaagct ttccggcatc 891721 ataaatcata ataggcagag aatattttaa tgcgaaaaaa tcgattgtgt catgggccga 891781 gtctttactt tccatgaatt gttccttgga tatcgggacc agcatgtcct ccattggggt 891841 tgtttctccc tcaaatgaag ggttaagctg tttaaagagt ttctgccatt ccttgacgaa 891901 ggattcatcg gatataccgc cgtccgcata gtcgaaaaac aaggattctt gaaacaggcg 891961 gagtctgcct ttcagcattt gcggtgagga gccgacttcg atattctcat aaatgacagc 892021 agctgcatgt aagccggccg cacgttcagt aataacagaa tcaagtttga tattcactag 892081 cattcactcc agttacgtga tatcaaccta ttataaacgc tgtgtcgttt tatcacaaag 892141 aaaggaggct gtgcaaaaca tgaacgttta tcagctcaaa gaagaattaa ttgaatacgc 892201 gaaaagcatt ggcgtagaca agattggttt tacgaccgct gatacttttg acagtttaaa 892261 agaccgtttg attcttcaag aatcactcgg ctatctctcc ggctttgaag agccagatat 892321 cgaaaaaagg gtgacgccga agcttctttt gccgaaagcg aaatcaatag tggcaattgc 892381 tctcgcatat ccttccagaa tgaaggatgc gccgagaagc acgagaactg agcgcagggg 892441 cattttttgc agagcttcct ggggaaaaga ctatcatgat gtgctgaggg aaaagcttga 892501 tctgctggag gattttctaa aaagcaagca tgaggatatc agaacgaagt caatggttga 892561 tacaggtgaa ttgtctgatc gcgccgttgc ggaacgtgcc ggaatcggat tcagtgcgaa 892621 aaactgtatg atcacaacac ccgagtatgg ctcttatgtg tatttggcgg aaatgatcac 892681 aaatatccct tttgagcctg atgtgccgat tgaagatatg tgcgggtcct gcacgaaatg 892741 cttggacgcc tgcccaacgg gagcactggt taatcccggg cagcttaatg cgcagcgctg 892801 catctctttt ctgacccaga caaaaggatt tttgcctgat gaattccgga caaaaatcgg 892861 aaaccgcctg tacgggtgcg atacgtgcca aacggtatgc cctctcaata aagggaagga 892921 ttttcatctt catccggaaa tggagcctga tcctgagatt gccaaaccgt tattgaagcc 892981 gcttttggcc atcagcaatc gggaatttaa ggagaaattc gggcatgtct caggttcttg 893041 gcgcggaaaa aaaccgattc agcgaaacgc cattctcgcg cttgcccatt ttaaggatgc 893101 ttccgcactg cctgaattga cggaactgat gcacaaggat ccgcgtcctg tcatcagggg 893161 gacagccgca tgggcaatcg gaaaaatcgg agaccccgcc tacgcggaag agcttgaaaa 893221 agcgctggaa aaagagaagg atgaagaggc aaagctggaa attgaaaaag gaattgagtt 893281 gctaaaagct tcaggcatga ctaaacaagg cctgtcctga catacgtata gagcagaagg 893341 aaaaaacact tgagatcatc caagtgtttt ttctctataa aaaagtatgg cgggtggggt 893401 gagcttgaag tacattttag aacaattagc ggaggagcgg ctgggctttc tggttaacgg 893461 gcatgctatg agacaggagt ctcaagtcgg agaccttaaa gtcatggagc gtaagaaaaa 893521 gcttctggaa aaacgtaaag ttgacatcat aaaagcgaaa gcaaaggccg tgattaatca 893581 tgtgcgggtt gaggatgacg gaacgacctg cctttcgtat accatccatt acgaatacgt 893641 gtgtaaggaa caagatgaca gcttgtatat agaagagcac atagaggagc gaatggcttt 893701 cctgtatgat cacattttga ttagtgatca ggaaattgcg aaaaagccgg ctggatttca 893761 tgaagggacc agtattattg actattctga agctgaagag gaaagagaag cgtttggcag 893821 ggcttttcaa tacgatcgtc tcggcgctgt ccaatatgcc gagaaatttt ggaacaagcg 893881 caatcctgct tataaaaatt tcagcgataa ctgtacaaat tttatttctc agtgtcttca 893941 tgcaggaggc gcgccgatgc gcggtcatcc gaacagggga tcaggctggt ggatgaaaca 894001 aagctcatgg agctacagct ggacggtggc tcactctatg aaaatgtatt tgtcgaattc 894061 aaaggccgga ctgcgtgcgg tgcgggtgaa atcagcggaa gaactgatgc cgggcgatgt 894121 gatttgctat gacttcgaag gagacggccg gtttaatcat acaacgattg tcgtggcaaa 894181 ggacaaaggc aatatgccgc ttgtcaacgc ccagacttat gacagcagga tgaggtattg 894241 gtcatatgag gattctacgg catacacgcc gtcaatacga tatgcctttt ttcatatcgt 894301 tgatgatacg acaaaagagt aattaatgtt ataatgatgg gcggataaga aaaacagagg 894361 tgaacattgt ggcattacat gtcgttttat atcaaccaga aattcccgct aacacaggga 894421 atattgcacg tacttgtgca gcaaccaata caacgctaca cctgattcgt ccgctcggct 894481 tttcaacgga tgataaaatg ctgaagcgtg ccggactcga ttattgggag tttgttaacg 894541 ttgtgtatca tgattcgtta gaagaattgt ttgaggcata taaaaaaggc aagtttttct 894601 ttattacaaa atttggccag cagcctcata catcatttga ttacactgat cttgacgagg 894661 attatttctt cgtgttcgga agagaaacaa gcggtttgcc aaaggattta attcaaaata 894721 atatggaccg ctgcctgcgt cttccgatga cagagcatgt cagatcgtta aatctgtcca 894781 atactgccgc gattcttgtt tatgaagcgc tgcgccagca aaattaccgt gatttaaaat 894841 agtgaaaaac ccgctcatcg atgatgggcg ggtttttttg cggatgttga aatgctttgt 894901 ttcgtttttg ggcttaacaa cgtaacagtg ttatgttaca atgtacccat caaaggagct 894961 ggacttatgg aagaacaatt aatctctaaa aaagaattac ttgaaagaac atcgatttca 895021 tacggtcagc tgtatcgatg gaagcggaaa aacttaatac ctgaggaatg gtttattcgt 895081 aaatccacat ttacagggca agagacgttt tttccgagag aggagatttt aaaacgtata 895141 tcaatgattc aaaagatgaa agaaaatttg tctttggatg aaatgaggga aatgctgtcg 895201 ccgaaaatga aggatgtcag catgaccgct gatgaattgc ttcataaagg tttggtttca 895261 aggcctgctc ttgaagccta ttcagaagac ggaggaagtc cggttttttc atccagcgat 895321 ttgctttcgc tgtttgtgct tgagggcctg ctgcagtctg gaaatgtcag ccttgcagaa 895381 gcaaaaatgg ctgcagaggt attaaagaag catgatactg aagagattga aaaacagacg 895441 gagctgattg tgctccgcaa gctcggtgtc acaacttgtt ttatagcggc tgcggcggac 895501 agcattttgt ttgaatcatc cgtaaaggtt gtggaacggg tagatttatt aaaagcttca 895561 gaggaattaa aaacaacatt tatgcaggag ggccatcaat ggatgtagtg gaaaagctgg 895621 tgataaatgg atcaggaagt tctaagggag gaacatttca atcagttgag attaatggca 895681 gcgggacagt ggccggggac gtggagtgtg acactttttc ttttaatgga aacggaaaag 895741 cggacggcag cgtcaaagcg aaagcggtaa ctatcagcgg ttcaggaaag atacatggag 895801 acgttgaagc agaatctatc cggatgaatg gcactggttt tattcaagga gaggtatctg 895861 caaaacaatt gaaaatcgct ggatcatcaa catttggcgg cactgtcaag gctgatggaa 895921 ttgacattag cggaaaagct gtcatggaag cagattgtga aacagaaacc tttcaatcag 895981 aagggaaatg caaaatcagc gggcttttaa atgcagacca ggtgatcatt aagctttctg 896041 caggggaaag ctatgcgcgg gagatcggct gccgccatct tcaagtgacc tgcagaaaag 896101 gaatgctgac attgctcaga ttgatgccgc agcctgttct aacagcagag ctgatcgaag 896161 gtgacgtgat tgaattgaca aatacaaagg cgaaaaccgt gcgcggtaat aaagtgatca 896221 tcggcccgga ttgccagatt gaaaccgtcg aatacagcgg ggactatacc tgtgatccaa 896281 gcgcgtcggt tgaaacatcc acaaagttgt aaggaggatc gtaatggaga caacaaaact 896341 gggaaattta aaattatatg gcgctgggca tgccgcagga ggcgcgtatc acaatgtcag 896401 catcaaagga gaaggtatag ttggagaagg gctgtctgct gtaggctgcc gcatatacgg 896461 aacgggcctt tttctcggaa aagcagagac tgagcggctg cgtgtgctcg gagaaagtga 896521 atgtaaaggc gatctgacag ccggcaaaat caatatatat gggacaatga aagtcagcgg 896581 ctcacttcaa tttgatcgat tcaatctgaa aggccagact gaaattggcg ggaatatgac 896641 tggagaatcc tgcgatgtga aagggaagct tagcgtaata ggtgattgtg aaacagaaat 896701 gttccatgtc acaggctgtg ttgatgtatc ggggttatta aattcgggtg agatcaagct 896761 gggattgagc catgatataa gccatgtgca ggaaatcggc ggaacaacaa ttacagtgaa 896821 aagacgcgcg agttttttta gccggaagaa agggaagctg atcgccgatg tcatagaagg 896881 agatcgggtt tatttggaga ataccgaagc ggcagttgtc aggggaaaag aagtgatcat 896941 cgggccggga tgcagcatcg gaacgattga gtacgaatac aaatgtgaat gcgatccgca 897001 ttcacagatt aaagaaaaaa caaaactgta aaacattgtt ctgttataca aaaagggtgc 897061 tctttcagga gcaccctttt ttattctttt ccaggcttgc tttcgtatcc tgcggtaaaa 897121 attgatacta aaaaagtgac aatgacaccc atcatgatga ttgttttcac cgtctctccc 897181 cctcttcaat ttttccgtgc tgtccgagtc tggatgattc tgtatttttc tttattatga 897241 acggtcgcag tctgccttgt caacgatgta tgagtatctt tatttttaag aaaccaaagc 897301 atgtatcacg agatggcggc atagattgta tcaaagtacc ttatttgcat agtgtatcaa 897361 acatgataga ggaggtcctt atggatatat taaagaaaat tgaaaagtac agagaggaag 897421 agcagcggct gaaatgggaa ggaactttcg ccgattattt ggagattatt aaagaaaatc 897481 cgatggtcgc gcaatctgct cattctcgag tttttaatat gataaaagac agcgggatag 897541 aggagattga cggacgcaag aagtacagtt tttttgaccg cgagctgttc gggcttgaag 897601 aatctctgga gcgtcttgtg gaagagtatt ttcatccggc tgccaaacgt ctagatgtca 897661 gaaagcggat tctattgctg atggggcctg tgagcggcgg taaatccacg ctggtcacaa 897721 tgcttaaaaa aggtctcgaa gcgtacacgc tgacagataa tggcgctgta tatgcgatta 897781 aaggctgccc gatgcacgag gaccctctac atttaatccc ccatcattta cgcgatgact 897841 tttacagaga atacggcatt agaatagaag gaagtctttc tcctttaaat gtcatgaggc 897901 tggaggaaga gtacggagga agaattgagg atgtgaaggt ggagcgcatc ttcttttcag 897961 aagataagcg tacgggaatt ggaacattca gtccctctga tccgaaatct caggatattg 898021 ccgatttgac ggggagtatt gatttctcaa caatcgccga gtacggttca gaatcagatc 898081 cgcgcgctta tcgatttgac ggagagctga ataaagcgaa ccgcgggatg atggagtttc 898141 aggagatgct gaaatgtgat gagaaatttc tctggcattt gctttccttg acacaggaag 898201 ggaattttaa agctgggcgg tttgcgttaa tttctgctga tgagctgatc gtggctcaca 898261 cgaatgaaac ggagtatcgc tcatttattt ctaataagaa gaatgaagcc ctgcactcaa 898321 gaatcatcgt gatgccggtt ccttataatt taaaagtgtc tgaggaagag agaatttatg 898381 aaaaaatgat tgcagaaagc gatgtggcgg atgttcatat tgccccgcat acgttgaagg 898441 tcgccgcgat gttctcaatc cttacccggt taaaagagcc gaagcggtcg gatattgatc 898501 tggtcaagaa aatgagactg tatgatgggg aaagtgtgga aggatataac tctgtcgacg 898561 ttgaggatat gaaaaaagaa tataatgatg aaggcatgag cggaattgat ccgcggtacg 898621 tgatcaaccg gatttcttca acgattatca gaaaaaatat ggaatcgatt aattctctcg 898681 atgtccttcg ctccttaaaa gaaggtcttg atcagcaccc atcaatttca agcgaggaca 898741 gggagcggta tttgaatttt atctctgccg cccgcaagga atatgacgat attgcgaaaa 898801 aggaagttca aaaagcgttt gtttattcat atgaagaatc agcaaaaaca cttatggaca 898861 attacctcga taacgtagag gcctattgca ataaaaacaa gcttcgtgat cctttgacag 898921 gagaggaaat gaaccctgac gaaaagctga tgagatccat cgaagagcag atcggcattt 898981 cggaaaacgc caaaaaagcg ttccgcgaag aaattttaat ccgcatctcg gcctatgcga 899041 gaaaaggcaa gcggtttgat tacaattccc atgaaagact gcgtgaagct attcagaaaa 899101 agctgtttgc tgatctgaag gatgtcgtta aaattacgac ctcaacaaaa acgccggatg 899161 agcagcagct gaaaaaggta aatgaagtcg tggcccgttt aattgatgag cacggctaca 899221 actcgacgag cgccaatgag ctgctgaaat atgtcggcag cctgctgaac cgataagcaa 899281 cgtgacccgt ccgaataggg cgggttattt tgtcccattt tctaaatagt ttgtcaatta 899341 aacgtgcata tgtgcatatg atgaatataa atcttttcaa aagacttgtt tcataatctg 899401 gcacaagccg gaatacgtat gtatcacgac cacaaatggt taaggagggg aattcatgtc 899461 ccaaaatgac agcggccatt ttttgatttc tgaggaaaac tggtccctcc atcgcaaagg 899521 cttcgatgac cagcagcgcc accagaaaaa agtgcaggaa gcgatcaaaa acaatcttcc 899581 ggacctcgta actgaggaaa gcattattat gtctaatgga aaagatgtag tgaagatccc 899641 aatccgttca cttgatgagt ataaaatccg ttataactat gataaaaata aacatgtagg 899701 gcaaggagac ggcgagagcc aggttggaga tgttgtggcc cgggatggat cagacaaaaa 899761 acaagggcct ggaaaagggc agggtgccgg tgatcaggca ggcgaggatt attatgaagc 899821 ggaagtttca ttaatggatt tagaagaagc gctttttaaa gaattagagc ttccgaatct 899881 ccagcaaaaa gagcgggaca atatcattca tacagatatc gagtttaatg atatccgtaa 899941 aacagggtta accggtaata ttgataagaa aagaacgatg atgtcagcct ttaaacgaaa 900001 cgcaatgtca ggaaaaccgt cgttctaccc aatttatccg gaggacctga aatataagac 900061 gtggaatgac atcacaaagc ccgaatcaaa agccgtcgtt ttagccatga tggatacaag 900121 cggcagtatg ggggtttggg aaaaatacat ggccagaagc ttctttttct ggatgacccg 900181 ttttttgcgg acaaaatacg agactgtgga aattgaattt attgcccatc atacagaagc 900241 aagagtggtc tcggaggagg attttttctc aaagggagaa agcggcggaa caatttgttc 900301 ttccgtatat cggaagtcgc ttgagcttat tgatgaaaag tacaatcccg cccgctataa 900361 catttacccg tttcattttt ctgacggtga caacctgaca tctgataacg cgcgctgtgt 900421 gaagctggtc aatgatatta tgaagaaggc caatctgttt tgctacggcg aggtcaatca 900481 gtacaacagg cattcaacgt taatgtctgc atataaaaat gtaaaagatg agaaatttaa 900541 gtactatatt ttaaaacaga aatctgatgt ttttcaggct ctaaagaact ttttcagaaa 900601 tgaagagtct ggtgtaagcc atcaattttc gtaatgaaaa gcccatttca gggctttttt 900661 ttatttaata aaagcaagaa aacgcttgcg aaaaaaatac gggagaaaaa gaaatttttc 900721 ctttgacaaa tcttctttca tttattaata ttttatcttg tgaactatta ttgaggaatg 900781 aggtgaaaag gagttgactg aatcagaacg tgctttgctc acttttgaac agctcttcga 900841 tacgtctcgg gcgatatata aaaaacagaa gaagatattg gagattgtgc ttgagccttt 900901 tgatattaca gtccttcaat atttgctgat gtttaaaatt catcaaagcg gaagcacccc 900961 gctaagcaag ctggcaatgt cgcttgatct taagcctgct tctgtgacgc ggatgacaga 901021 tattctgtat aagcgccaat tgatgaatcg atatgacagt ccggatgacc gccgtatcgt 901081 catgattcag ttaaccgaag agggggaaga actgatagaa aaagccgctg tgcaatatgc 901141 aaaaatgggt gctggcttgt accaaaagct tgatacctcc cagctgcagt atttgcgcaa 901201 actagccgga agtttaacga agcttgctga aggctgttca gaaaaaagcg gtaattaaaa 901261 acttctcaca tattttcacc agctttccgc aaaatgatag aggatgaaac gaaaggagaa 901321 aacaaaatga acagaggacg tttaattctg accaacatta tcggtttgat tgttgttctt 901381 gcaattatag ctggaggtgc ttactactat tatcaaagca caaactacgt aaaaacagat 901441 gaagcaaaag tagcgggcga tatggctgct attactgctc cagcagcagg taaagtatct 901501 gactgggatc tggacgaagg aaaaacagtg aaaaaaggcg acacagttgc aaaaatcaaa 901561 ggtgaacaaa ctgttgacgt aaaatccatt atggatggca caattgtgaa aaacgaagtg 901621 aaaaacggac aaaccgtaca agctggtaca acaattgcac aaacgattga catggacaac 901681 ctatacatca cagcaaatat taaagaaaca gatattgcgg atattgaagt aggaaatagt 901741 gtagacgtag tagttgacgg agaccctgat actacatttg acggtactgt agaagaaatt 901801 ggttatgcga ctaactcaac ttttgatatg cttccttcta caaattcaag cggaaactac 901861 acaaaagtaa cacaaaaagt tcctgtgaaa atttcaatca aaaacccatc tgataaggtg 901921 cttcctggaa tgaatgcatc tgttaaaatt tctgagtaaa acagatcagt catcaaacca 901981 tgaaaggagg ttgtcttaga tggctacagg caaagaaaaa aatgcaaaaa accctatgtc 902041 attgctgatt gtgctaatgg cgggtttatt tttggcaatt ctaaaccaaa cactgcttaa 902101 tgttgcaatg ccgcacttaa tgactgaatt tggcgtaagt gcaacgacga ttcagtggct 902161 gacaacaggt tacatgcttg ttaacggtgt attgattccg ttatctgctt tcctgattac 902221 acgatttggc cagcggagtc tctttctcgt cgcgatgttt tgttttacgc tcggtacgtt 902281 agtctgcggt atcgcaccta acttctctac aatgctgatc ggccgtttga ttcaggccgt 902341 gggcggaggt atcttgcagc cgctcgttat gacaaccatt ctgttaattt tcccgcctga 902401 aagcaggggg aaaggaatgg ggattttcgg gctagcgatg atgtttgctc cagcggtcgg 902461 cccgactctt tccgggtgga ttattgagca ttatacatgg cgcattatgt tttacggact 902521 tgtgccgatc ggcgcaattg ttatcattgt ggctttcttc atctttaaaa atatggtgga 902581 gccgcaaaaa atcaaactcg atactcttgg cgcaatcctc tcgattgtcg gattcgcctc 902641 cttattatac ggagtcagtg aagccggatc tgacggctgg accgacccga ttgtattgtc 902701 tacagttatt atcggagcca ttgcaattgt tgcttttgtt gttcagcaat tgcgtcatga 902761 tgatccgatg cttgatttca gagtgtttaa atatgacatt ttctcactct cgagtgtcat 902821 taatatcatt attacagtgg cactttacac tggtatgttc cttttaccga tttatctgca 902881 aaacctggtc ggctttacgg cgcttcaatc cggtctgctt ctgcttccgg gtgcgatcgt 902941 tatgctgatt atgtcaccga tctcaggtat tttgttcgat aaattcggac cgagaccgct 903001 tgcgattatc gggcttctcg tgacagtggt aacaacgtat caatacacgc aattgacaat 903061 tgatacacca tatacacaca tcatgctgat ctattcaatt cgtgcatttg gtatgtctct 903121 cttaatgatg ccagtcatga cagccgggat gaaccagctt cctgcccgtc tgaacagcca 903181 cggaacggcg atgagtaaca cgcttcgcca aatcagcgga tcaatcggaa caagtttaat 903241 tacgacgatt tatacaaacc ggacgacatt ccattattca caaattgcag ataaaacaag 903301 cacggcggac ccgaacttcc tccatgcgtt ccaaaatgca gtttcgaatt taatggtgaa 903361 tatgaatgtg tcttatgata cggcgaaaac atatgtgtac tcacatattt ataaacacgc 903421 atcactcgat tccaatgtca tggggataaa tgatgccttt atgtgggcaa ccttattctg 903481 tgtagcaggt ttgattttaa gtatcttcct gcgtgacgtc agaaaagata aattgcgtaa 903541 gaagaaaaaa gaggagcttt cattacttcc tgctccaaaa gaagctaagg aatcttaatc 903601 tgtacaggga ggtttcctga atgaaaattt atgtagtgta tgatagtgaa ggcgaacata 903661 ctaaagtgct tgcagaagcg attgctgaag gcgcgagaga aaacgacgcg gctgaagtgt 903721 tcatcgacca tgtagatcag gctgatatcc gcaagcttaa agatatggat gcgattattt 903781 ggggatgccc agggcatttc ggaacaatca gctccggtct taaaacttgg atcgacagac 903841 ttggctactt gtgggctgaa ggcgagctga tcaacaaagt cggtgctgtc ttctgcacaa 903901 cggcaacaac acacggcggc ttggaaatga caatgcacaa tttaatcacg ccgatgttcc 903961 accaaggcat gattgttgtc ggactgcctg gcaacgtgcc tgaaaacgca ctttatggct 904021 cttattacgg agcaggtgtc acttgtccgg tagacagtga tgagttaatg tctgaggaag 904081 gtattcagct tggacgcgcg ttgggaagac gtgtcagcca agtcacagga aacctaacag 904141 caggacagta aggagaggtt gaaatggcca ttattatagc aataattgct gctgtcattg 904201 tcattgcggc ccttattaca tttaacgtcc gcaacgcctc acctggacct gagaagcaag 904261 aagcaaccga tagaatcgca cctccagaag aggaaaaaaa cgaagcgcat taccctgctg 904321 aagcaagggc tgccgagcat acgccatccg ttgtcaaaaa cgattctcca aaagagaagc 904381 gtgacacaat gggtgatgat atttacaggc aggcgctgca aaagtttaag cattctgatg 904441 aagttcatgc agaagaagag gtcactgagg aaagtgacaa aatgcaggac cgcagctatc 904501 gtgatgcgct gctctctatg aaaaataaga aaaagtaatg aaaaaggcaa atccgtttac 904561 tcatgcgggt ttgccttttt tgctgtttcc atcaattatg tttttatcaa ataaatccat 904621 ggaatatgtt gtattccacc ttgatctagt gtactatgtt actcatacac cgaggatttt 904681 ttccgggagg taaagacatg aattcttttt taggtttatt aaagaaagat atcaagcttt 904741 caagaatgtg gctgctagta tggatatgcg gaatcatttt cttattggga acaggccata 904801 ttatagcttc tcgcacgaaa gaacctctag tcatttttgg tttttttgtt gcagttgctt 904861 tttttctgct tttcttatct cctgtttttg ttttttatca ccttcgcaag gaagggaaat 904921 cacagctttg gctgtacaat ccaaatggcg gcttatggct gttttcttct aaattggcag 904981 catctttgct ctatcaattt gtgattcagt tggcattaac agcctatggc atatggatgt 905041 atcatatgct ctctgtaaaa aatctgctgg agcatcaagt tgatataacg agtacagtgg 905101 ctttgctgaa tatgtatggg cttatttctt cgttagatat gtcagtaaca gtcattgtgt 905161 tttggactgt ttttcactct ctcagaaatt ggcgcggaat gcggtgggct gcgatggttc 905221 tgttggtcgc aatgtggtta ttcttcgatg aatacatcat aagccctttg gttgaatctc 905281 aaaagcattt ctggcctgta acagtctatt gcaattttga tttccacttc cacaatgttt 905341 ggagattgga actaaaacct atccatctgt ctgtgctagg gtttcctatt gctatagtca 905401 tcacattctt gctgctcatc atggcttcaa aactgcttga tcgtaaagta gaggtgtaaa 905461 tatggacaat caattccaat cctcgaaacc gatttatctg cagatcgctg atcagatctt 905521 ttataggctg gtcaggaagg agctgctccc aggagacaag cttccttcag taagagaaat 905581 ggcgattcaa actaaagtaa atcccaatac aattcaaaga acttacagtg agatggaaag 905641 gctgggtatt gtggagacaa gaagaggtca agggacgttt attgcggaaa aagcagaaat 905701 cgtagacgag ctgaaagaca agctgacacg agaggtgctg gaaggctttg tcaagcaaat 905761 gaaagagctg gggctaacga aagaagaaat gttagaaggg attaaaacat tcacagaggg 905821 aggctaaaat ggaaatcaag ctagaacatg tatcaaaaaa atacggccgc catacggccg 905881 tcaatgatgt gtcaatcacc ctatcatccg gacggattta tggcctgatt ggaccgaacg 905941 gcagcggcaa gtcaacgacc ctgaaaatga tggctggcct tctgtttccg acttcaggat 906001 ttgtaaaagt tgatgaagag caggttacga gagaaatggt gcgtcaaacg gcttatctta 906061 ctgagcttga tatgttttat ccgcatttca ctgttaaaga tatggtgaat ttttatcagt 906121 cgcagtttcc tgattttcat acagaacagg tttataagct attgaatgag atgcagctga 906181 atccggaaaa aaagatcaaa aagctatcaa aaggaaatcg gggcaggctg aaaatcgttc 906241 ttgctttagc gagacgggca gacgtcatct tgcttgatga acctttttcc gggcttgatc 906301 cgatggtcag ggattccatc gtaaacagcc ttgtgtcgta cattgatttt gagcagcaga 906361 ttgtcgtgat cgcgacacat gaaattgatg aaattgagac tttgttagat gaagtaatca 906421 tcctcgccaa tggagaaaaa gttgcgcagc gtgaagtaga agatattcgt gaacaggaag 906481 gcatgtctgt tttgcaatgg tttaaatcaa aaatggaagt ttgctagaaa gaggaggaat 906541 atgatgaaaa cagtgttgga attgaaaaac gtgactaaaa acatcagagg ccgaacgatc 906601 attgatgatc tcagttttac gattcgtgaa ggcgaggtat tcggtttttt aggaccaaac 906661 ggagcgggga aaacgacaac catccggatg atggtggggt taatgaagct gtcgaaaggt 906721 gatgtcctca tttgcggcca atcaattacg aaagaatatg ccaaggcgat taagcatatc 906781 ggagcgatcg ttgagaatcc cgagctgtat aaatttttga gcggatataa aaatctccag 906841 caattcgcaa ggatggtcaa gggtgtcacg aaggaaaaaa ttgatgaagt tgttgaactg 906901 gtcggtttaa cagacagaat ccacgacaag gtgaaaacat attctctggg gatgagacag 906961 cgtcttggct tggcacaatg ccttctgcac gatccgaaag tgctgatttt ggatgaaccg 907021 acaaacggcc ttgatccggc ggggatcaga gaaatcagag atcatttaaa gaagctgacc 907081 cgagaaagag gaatggctgt catcgtttca agccacctgc tgtcagaaat ggaactgatg 907141 tgtgatcgaa ttgcgattct gcaaaaagga aagctgatcg atattcaaaa tgtaaaagat 907201 gaaaacattg atgagaatga tacatatttc ttccaggttg agcagccgag tgaagccgct 907261 actgttttaa atcagtacga tttgctgagt aagacaaatg gtgtagaaat caaactggct 907321 aaagaggaag tccctgcggt tattgaattg ctggtgatgc agcaaatccg tatttatgag 907381 gtcaaggtca taacaaaatc attagaggac cgtttcttag aaatgacagg tgaaacaaaa 907441 gaggaggttc agcatgctta atttgattta taatgagtgg ctcaaaattt tcagccgtgc 907501 cggaacatgg gtgatgatcg gaattctggg gctgacaatg gttggatttg catttttggc 907561 gaatcatttt tctgccggtg aatcaaattc ccattggaaa caagagcttc aagcacaaaa 907621 cgccgaatta aagaaagaaa tcaaagaaga tccttcactg aaagatgggt ataaagaaac 907681 aatcacactc aatgactatc gcatcgagca taatatccct agtgacacgg gctatacggt 907741 atggtcttat gtaacggatt cagcaaactt taccatcctt accggtctgt ttactattat 907801 catcgcggcc ggaattgtcg cgaacgaatt taattgggga acgattaagc tattaatgat 907861 tcggccgctc agtcgttttc aaattttgat gtccaaatat attacagttc tcctgtttgg 907921 gctcctgttg ctgttgattt tatttatcgg ttctacttta ttagggttga tcttcttcgg 907981 aacgggtggt gaaaccgccg cgaatattca tttaatctat aaggatggcc atgtcattga 908041 gcaaaacatg atggggcatt tggctacaac gtatctttct gaatccgtct cggctttaat 908101 ggtggcgacg atggcgttta tgctgtctgc ggtattcaga aacagctctc ttgcggttgg 908161 tttttccatc ttcttgttgg ttgccggtac gactgcaact gcatttattg cagcgaaatt 908221 tgactgggca aagtatatat tgtttgctaa tgtcgacttg actcagtatg tggatggcac 908281 accgttaata aaagggatga ctatgacgtt ttctctcgtc atgctggcga tctactttat 908341 catcttcctg ttgcttgctt tcggaatctt catgaagcgg gatattgcaa actaataaaa 908401 aaagctgttt tgcttatgca aaacagcttt tttgtcaaaa taaaaactgc aggtttgcac 908461 ctgcagtttt tcatatcaat ttatgcttac gcttctttag taacgttagc agcttgtggt 908521 ccgcggtttc cttcaacgat ttcaaaagaa acagcttggc cttcttctaa agttttgaag 908581 ccttcgcctt gaatagcaga gaaatgaacg aatacatcgt cttgaccttc tacttcgatg 908641 aatccgaaac ctttttcaga gttgaaccat tttactttac cttctaacat gaaatttcct 908701 cctaaagcga tcataacgct taaattcact attcttgctc ttaacaaact ttcaagacga 908761 aaactcttac aaaactttct tcttaaagat agttcgaaca aaaataatta cctttactct 908821 accagtaatc ttcagaaaaa acaactgctt attgaaattt ttttcggaaa ataccatatt 908881 tatttttcaa tttgatattt atttacggaa attcatctgt tttctcgata tgtgatcata 908941 cgtttgcctt agtattcctt cattttggga agataagtaa taggaattga caaccttatt 909001 ggatatgagt aaggtaaaag ttaatcaata ttacaaatga caacgtttat caactaagag 909061 agcgtatgat ttttatgtct gatattgctt gcatgctcta atacatagat aggagtatgg 909121 tcacaatgaa aaagtggctt atatgcagtt tcgtccttgt tcttctcgtt tcatttactg 909181 catgttcacc gtctgcagaa catgaatcga taaaaatcgg gattgctgag tctgacgggg 909241 caatatggaa ctatattgct caaaaggctg aagaggcagg gctggatatt cagctgatcc 909301 ctttttctga ttatgcggag tctgatatcg cacttgctaa caaagaaatt gatgccaacg 909361 cctttcaaac catttcatat tttcagtcgt tcactgaaaa atacaaactt aatttggcac 909421 cgctcgggac gacatacata acgcccatgg gcatttattc aaaacgatat gaacgaatcc 909481 gagatatatc gcggggagct gtcgtttctg ttccggataa agcgttcgat tttggcaggg 909541 cgcttacggt gctccaggaa gcgggtttgc taacgctgaa aaacggattt aacggaacag 909601 gttcagttga tatgattaaa gataatccga gacacctgaa attaaaagct gtccggcaac 909661 aggatgcagt gagcggtgcc gacgtgtttg tcatgaaacc atcagaagca aaaaaagcgg 909721 gcttgaaccc gaaaaagcat acgctaaaga gcggcggact catgtctgag gaagagatga 909781 atttgattgt tgtcagagcg gaggatcaag atcgggaagc gctgcaaacc attcttgagc 909841 tttatcaagc tgatgataca gcggcattta tagaaaaaga atatcaggga gatcttgtcc 909901 cggcttttct gcctttgaaa cgtctttcag attggaagaa tgaattcgaa cattgaattc 909961 attctttttt ttctgaaaaa cacactctgt tccgtcccgt ttctttcgct ttgtaaagca 910021 tttgatcggc aagaatgggc aaggatcctg gctgttccgt attattgggg taatgagcgg 910081 cccctagtga tatcgtaact gaaagctcgt cgccgtttgt taatacaatc ggtgcatcac 910141 ttacagtgct cctgatccgt tcagcgatcc gggctgcttt atcaagagaa cagttcggca 910201 ggagcacggc aaattcttca ccgccgatcc gagcggcagg atcagtattt cggatggtct 910261 gcttcagacg taaccctagc tctttgagca cctgatctcc ttcatgatgg ccatattggt 910321 cattgatggt cttaaaatga tcgatatcca tataaatcag tgcaaattga aaatgcgggg 910381 tatcggccgc ctgctgatac agagcttttg tggtttcttc aaattttctt cggttataca 910441 cgcctgttaa aaagtcaaag tgcgcctgaa acttatattg tttaaaaaga agatgtgcat 910501 ttgtttcatg atcaataata tataaactga gcatgccgcc cgctattgat atgatccaaa 910561 aatacaaatg aagttcgtat gaatgtaaat ctataagaaa ataaaaggaa aaggagatca 910621 agctatttgt gattattaaa agatagaaag catgttttag ttgaactttt tttcttctag 910681 aaacaatgag tgacggaatg gcagcgatac aaatgataat aaccgagtat agtgcagatg 910741 tgttcatcgt aatcagcaag cggcctgcag tgatcatggc cagggccgtt gccgttgaaa 910801 cccagcctcc ataaagagcg gcaatcataa tagggatatt tcgaagatca ataattgaat 910861 gctgataggt aaatccaaaa accatcagaa taaccccgag caaaccgcag gccagtcctt 910921 taacagcttg aaaggatatg ctgtcttttt tatgtactag cctttcttta aacaggtggg 910981 tgaagagata attaaatgtg attaaaatgg tcaaatttac aaacagttct ttcagcaaat 911041 attatcaccc ttatataagg tactaaagat ggaagggaaa gaaaagaaca aaaaaggcat 911101 tatataaggt ttttttactt gaattgataa gttaaaataa ttcgcacttg acccatcgga 911161 attagtgtaa tatagtaaat gagaaaattt gaagggagag tttacctgct ttggagactt 911221 tactggttgt attacatgta tttattttat ttttacttat cttagggctc tttgttatgc 911281 agaaaaaaca tgtttccttc tctaaacgtg tatttactgc gctggggctg gggattgtat 911341 tcggatttgc gcttcagctg atttacggcc cgacttcaaa tatagtcatt caaacagccg 911401 actggtttaa tattgccggg ggcggatatg tcaaattgct tcagatggtt gtcatgccgc 911461 tcgtctttat ttcgattctc ggcgccttta caaagctgaa gctgacaaaa aatcttggga 911521 aaatcagcgg tttgattatc gggattttag tagcaacaac agcagttgct gcagctgtcg 911581 gtatcgcgtc cgcgctttca tttgatctgc aggcgattca ggttgaccaa ggaagtacag 911641 agctttcacg gggacaggag cttcagcaga aatcagagga tatgacagcg aaaacgctgc 911701 cgcagcagat tgttgaactg ctgcctggaa acccgttttt agattttacg ggagctagac 911761 cgacttcaac gatcgctgtc gttatttttg ccgctttcct tggagtggca ttcctcggcg 911821 taaaacacaa acagccggaa caggcagaaa catttaaaaa actggttgat gccgtttatg 911881 ccattgtcat gcgtgttgtc acactcattt tgagactgac gccttatggg gtgctggcca 911941 tcatgacaaa aacaattgca acgagtgatc ttgacagcat tctaaaactg ggcatgttcg 912001 tgattgcatc atatgccgcg ttaatcacta tgtttatcat tcatttgctg ctgctgacgt 912061 tcagcggctt gaatccggtg atttatttga aaaaagcggt gcctgtactt gtatttgcat 912121 ttacgtcaag gtctagcgca ggtgctttac cgctgaatat taaaacacag agaagcatgg 912181 gtgtaccgga gggaatcgca aactttgccg gttcgttcgg tctttcgatc ggccaaaatg 912241 gatgtgccgg catttatcct gcgatgctgg cgatgatgat tgctccgact gtcggccaaa 912301 atccatttga cccggtgttt attatcactg ttatcgcagt cgttgccatc agctccttcg 912361 gggttgccgg agtcggcggc ggagcgacat tcgcggcgct tcttgtttta tcatcattaa 912421 acatgcctgt cgcgctcgcc ggtttgttaa tctcaattga accgttaatc gacatggggc 912481 gtactgcttt gaatgtcagc ggaagcatga catccggtct tattacaagt aaggtcacaa 912541 aagaaattga tcaaggggca tttcatgatc aatccagagt gattgaagct gaagaagcgt 912601 aacatatgaa aacgtgtaat ccaagaggat tacacgtttt tttaacggcc aggctctaag 912661 tcctccagca tttccatcat cgtgttgtcg tccatgacat tcattgcgtt ttgttcaaaa 912721 tgaatgggtt cagcataatg cggctgtctt tttttcgcgg ctgtctcagt ttgcctagtt 912781 tgagactgtg tatgctgatg ctgtggttgc tgctgtccag cgtgctggtg ctgacggcca 912841 ttttgccgct ggctttgatg ctgcgaacgg tcctggttat caccgctgct tccgctgctt 912901 ccgctaaatg cttgtttgac catgtttcct acattagaag catcaaacgt gttattttct 912961 gaatttcgtc tgttcatttg tcctgtgata aacccgctga ttctttggcg gatctgaggt 913021 gataatgcag taataagcat agttgatcct atgatcaatg ctgcggggct gattcctctt 913081 cgctggttga acaacatgat ccctcctttg cagtgtattc atattttccc cctcgttaga 913141 caaattaacc gttatatttc ccgggaaagc atttcctcca gatttgcatg cataattaaa 913201 gccagttaga aaaacctata agtaaagtga taaaggagga attcacatgt ttggaaaaaa 913261 acaagtcctt gcgtctgtgc ttcttatccc tttgcttatg actggctgcg gtgtagccga 913321 ccaaggtgag ggcagacgtg ataataatga tgtaagaaac gtaaattatc gaaatccggc 913381 caatgacgat atgcggaatg taaacaatcg ggataacgtt gacaacaatg ttaatgataa 913441 tgtcaataac aatcgtgtaa atgacgataa taacaacgac cgaaaacttg aggttgctga 913501 tgaagcagct gataaagtaa cagacctaaa agaagtaaag catgccgata tcattgtggc 913561 tggaaatcaa gcctacgttg cagtcgtttt aaccaatgga aataaaggtg cagtagaaaa 913621 caatctgaag aaaaaaatag ccaaaaaggt aagatctact gacaaaaaca ttgataatgt 913681 ttacgtttca gctaaccctg attttgtaga gcgtatgcaa ggatatggaa agcgtattca 913741 aaatggtgac ccaatcgccg gattatttga tgaatttaca caaactgtac agcgtgtatt 913801 ccctaacgct gaataaatga aagaagccgc acaatttgtg cggctttttc tttgcgttaa 913861 tgacacactg cgaactcagg ctgcatagag taaaaataaa aaggtacaag acggaccggc 913921 tcagggaggg agacgtttgc gggatggcat aggaaagcgt gcggcatccg ctctattcct 913981 gtgcggagtc cttgtgatgc tggctgtaag ctcagccatc gtatcaagcg cgatgtatat 914041 cctgtctttt ccaggtcagg catctggaat aacaaaagaa caagtgacga agcacatgaa 914101 gaaagagtca ttcaaacagg ccgatattta ttacacttct aaggaaaagt ccttactgcc 914161 attgacgaaa gaaacgcttg aatatgcggt cagtattaat cagattatga ttggatattc 914221 gaatcaaaag cctattgaca ttattttttt tcctaatgaa aaacagatgg aggcttactc 914281 cggtttattg gatgtagttg gtttttattc tgaacgggag cagctgatcg gattgttgcc 914341 tgaagagaaa aagaaactgt tagaagggga cgaggtagcg gtttatttgt accagagatt 914401 gttgattcat gaatactcgc accatgcgtt tcaccagaaa ttgaaggagc ttgagacgga 914461 tcccgatgag tttccgttat ggtttcatga agggttaagc gagtggattg cgaactatga 914521 attgctcata gatccgatca cgttttctgt cgtgcccttt gaccgtttgc agactgatcg 914581 agactggcag gaagctagag ccgaatatga cactgatgtc tatttgcaaa gcttttatat 914641 gatcgatgag ctgacggaca aatacgggaa agacattatt tcagaaatga ttaaggaaac 914701 ggcaaaaaaa ggggactttg aaaaagggtt taaatcagca acaaaggaaa gtcttgatca 914761 atttgaaaaa gattttaaga aaaaatttga aaaaaacagt gcggcattgg atagtatcta 914821 tccaatgcct ttgttattag tgaagtcctt gctgacccat tccgccttgt gtcggaggca 914881 tttgtccttg ggcaggggcg aatgaatttc gcagctgttc catatcctgc gcatcaagct 914941 gaggaacctg gtaatagccg tgtttgtttt ggtataggaa aatttcaaat gccatttcaa 915001 catactcctg aatttgcgca gacagtacgc gtcttacggc cggatttgtc atttccagag 915061 aagccatcgt cagcatagaa gcttgtgctt taatcgcgca aagcatttgt cggctgatga 915121 tgctgtcatc aatatcattc atggattgaa caggtttttt aggctgtgac ggctgcatgc 915181 cgtaaacagt ctggttgtct tccttcatca tataagttgc tgttttttgt gaaggttcgc 915241 ttcctgtttt gaagcattct gcagttatat tgtattgaga tgtgatgaat tgatgttgac 915301 gatcaaggat gtttagtaat tcttgatcct tacagaattg tctcagcatc ataaactgat 915361 caagcacagt aagtgttccg gaaagcacct catgcatatc aaacatttca tgtccgccgt 915421 ggtttttatg cggtttgcca ggaatacctt tgttcatttg ggattgctgc tgctgattga 915481 actgatccaa accgaattcc tccttttttt tcagatcagc tgtattttgt gtcagtctgc 915541 cgtgtattat gcagaagcct gaaaggaatt atatgctgtc tgtcgaaatg ataagcagac 915601 aaaatcgttg tcattatgtg tataagggag gaaatatgat gaggcgtatt ctgcatattg 915661 tgttgatcac ggcattaatg ttcttaaatg taatgtacac gttcgaagct gtaaaggcag 915721 ctgaaccgca acagcctata tcgattgaga aggcaataca gcaaaaagaa ggacaggcac 915781 ttgtcgaagg atatgcagtc ggccaggctg tttccccgca gcattataaa ctgacaagcc 915841 ctttttcaaa tgattataat gttgcgctgg cagaccgtaa aaacaaaaca tcgcccgaac 915901 acatccttcc tgtgcaaatc ccctccgcct tcagaagcca atttgggctg caaaccaatc 915961 cgcttcttct tgggaaaaag ataacggttc aaggaaagct tgaaaattac tttaacacga 916021 caggacttaa aaacgttcag tcgatgaacg taaccgatga cacaaaaact ccgccggctg 916081 aacagcaagt gaccataaat gaagcacggg gaaggctgaa tgaagaagta acgataaaag 916141 ggatcattac agctgatcaa aacgcaatcg gaggcgggaa gctgtcgacc tttttgcaag 916201 atgaaaccgg aggcattaac atttattcgc catcccctga acaatttccc gaattaaaag 916261 agggtatgga tgtcacggtg acagggaaaa tcacgtctta ccaggggctg aaagaaatcg 916321 ttccaaactc atcaggcatc aaaatcaacc agtcaaatca atccctcccc gcccccaaac 916381 acttaacaat caatgaactt attaacggca gcctaggtga tcagtatgaa ggacgccttg 916441 tgaaactaac cgcttttgtt tcctcaattc caagttctcc tgccggcggc ggttacaatg 916501 taacaatgat tgatgacgac catcatgcaa tgacgctccg ggttatgaat gaaacagggg 916561 tgataaacga gcttgatgag ggcaaatggt atgaatttac cggtgtgtta agcagatacc 916621 aaacctttca gctgcttccg cgaaaatcgg ctgacctgaa gctgcttgaa gagcagcccg 916681 cacctccgtc tgcagaggga gaatatgaag ggattgttga ccgggtagtt gacggcgata 916741 ccattcatct taaatctccg gtgcttggaa cgacaaaaat ccggtttgta aatgtagatg 916801 cacccgaaac atatcacaca ccaaaaaatg acgcagatga aaatcaatta agatttggca 916861 aaaaagcatc tgactatcta aaaacggttc tgtccccggg tgataaaatt actgtcaagg 916921 tcgggagtga agccaaggac agctatggca gattgctcgg acaagtcata accgaatcag 916981 gttcaaacgt gaacttagag cttgtaaaaa acggctatgc tccgacgtat tttatttggc 917041 cggttgacaa tgaagaggat tatcagcaat ttcaggccgc agtagccgct gcaaaaaaag 917101 atcaaaaagg aatttggaat gaaaacgatc ccctcatgga aatgccgttt gaattcagag 917161 ccagagagca agggaaaggc ctgacaagat atgtggggga ctcgtcgaat aaaacatatg 917221 tgcagccagc tgactggaag aagatagctg tggaaaacag aattttcttc gcctcagcaa 917281 gtgaagcgga gagcgcggga tataaaaaaa ggcaaacggc acctcaagaa catgtgccgc 917341 ttagaattct cagcatgaat gatttgcatg gcaaaatcga tcagcaatat gagcttgatc 917401 ttgatggaaa tggaactgta gacggcacgt ttggacgcat ggattatgcc gccgcatatt 917461 taaaagaaaa aaaggctgaa aagaaaaact cgctgattgt gcacgcggga gatatgatcg 917521 gcggaagctc tccagtttcc tctcttcttc aggatgaacc gactgtagaa ctgatggagg 917581 acatcggatt tgatgtcgga accgtgggaa accacgaatt tgatgaaggc acggatgaac 917641 ttctgaggat cttaaatggc ggtgatcatc cgaaaggcac aagcggatat gatggacaga 917701 actttcccct tgtatgtgcc aattgtaaaa tgaaatcaac tggagagccc tttttgccgg 917761 cttacgacat cattaatgtg gagggcgtac ccgttgcttt tatcggagtt gtcacacagt 917821 cggcagctgg catggttatg cctgaaggaa taaaaaatat cgagtttaca gatgaagcaa 917881 cagcggtgaa taaggcggcc gaagagctca agaaaaaagg cgtgaaggcc atcgcggttc 917941 tcgcacatat gtcagctgaa caaaacggca acgccattac cggtgagtct gctgatcttg 918001 caaacaaaac agattctgaa attgacgtga tttttgccgc gcataatcat caggttgtta 918061 acggtgaagt gaatggaaaa ctgattgttc aagcgtttga atatggaaaa gcgataggtg 918121 tcgttgatgt agagatcgat aaaacgacaa aagacattgt caaaaagtcc gcggaaatcg 918181 tatatgttga tcaaagtaaa atcgaaccgg atgtcagcgc gtcagccatt ttaaagaaat 918241 acgaaacaat tgcggaaccg attatcagcg aggtagtcgg cgaagccgct gttgatatgg 918301 aaggggggta ttcaaatgac ggcgatacac ctcttggaaa cctgattgcg gatggtatga 918361 gagctgccat gaaaacggat tttgccctta tgaatggcgg cggcatacgt gaagcgctga 918421 agaagggtcc aattacgtgg ggagatcttt acaatattca gccgtttgga aatgtgttaa 918481 cgaagcttga gattaaagga aaagatttaa gagagattat caatgcgcaa atctcgccgg 918541 tttttgggcc tgactacagc atcagcgggt ttacgtatac gtgggataaa gaaaccggaa 918601 aagcagttga tatgaaaatg gcagatggca ccgagatcca gcccgatgcc acatatacat 918661 tgaccgtcaa caactttatg gcgacggcga caggagccaa atatcagcca atcggactgc 918721 tgggaaaaaa tccggtgaca gggcctgagg atttggaagc gacagttgag tacgtgaaga 918781 gttttgatga gccaattgcg tatacaaaag agggaagaat taagcttgct gaagccagtg 918841 atattgaaga ccctgtaaca gaagacccga taacggaaga gcctggagat gatccgggga 918901 cggaggatcc gattaaagag gatccaaggc caggtgaaga tttgcctgat ataaaagaaa 918961 ctccgggaac agcaccggtt catcagcttc cgccttcagc catttcgaga ttcaatgaaa 919021 taccaatcaa caacacaaaa accgctgata ctgctaatag catcagcaca ttgccgttac 919081 aaaccgagac tgcggaaagc gggtctgatc atcagcttcc ggatacgtca gcgggctact 919141 ataactttat ggtaatcggt gcggcggtga cattgtcagg aacttatcta tatgtcagaa 919201 gaaaaaggag cgcctccaga acgtgaaaaa agttattcca ctattcatca ttgctgccgg 919261 cctagtgatc gcaggctatg gaggctttaa attgatcgat acgaatacga aaacggaaca 919321 gacattaaaa gaagcaaagc tggcggctaa aaagccgcag gaagcttcgg ggacgaaaaa 919381 tagcacagat caagcaaaga acaaagcatc atttaagcct gagaccggcc aagcgagcgg 919441 cattttagaa ataccgaaaa tcaatgcaga gcttccgatc gtggagggca ccgatgctga 919501 tgatttagaa aaaggtgtcg ggcattacaa ggacagctat tatcctgatg aaaacggaca 919561 aattgtgctg tcagggcatc gggataccgt gtttcgccgg acgggagagc tggaaaaggg 919621 ggatcagctc cgtcttctcc tgtcatatgg agaattcaca tatgaaattg taaaaacaaa 919681 aattgtcgat aaggatgaca catctattat cacgctccag catgaaaagg aagagctgat 919741 tctgacgacc tgctatccgt tttcatacgt cggaaatgcc ccgaagcgct atattatata 919801 tggaaaacga gtgacttaaa aagccgaggc agtgcctgcg gcttttcttc atgaaaaata 919861 tgtgcggcaa aggtttttca tatcagcagg gaaaggggct tcagcaacta tgagctcgtc 919921 tgttatcggg tgaaccgctt gtactttatt ggcgtgcagt gcctgcctgt ttagcagctt 919981 gctcccgcct ccgtaaagcg agtctcctgt caacggatgg ccgaggctcg ccagatgaac 920041 acggatttgg tgtgttctgc ctgtttccag ctctaattca acgagcgaca gccgttcttt 920101 cgcattgctg gccattacct tgaaatgagt gacggctgtt tgcccgcctg gtgaaacccg 920161 gcgtcttgtc gggtgtgagc ggtctctgcc gatcggtgaa ttaattgtcc cttttttcgt 920221 ccgtagctta ccttcagcga tagcggtata cgtacgcttc agcgtctttt tctctaactg 920281 ctggtctaag atggcgtgtg ccaaacgatg cttggcaaaa acgatagcgc cagatgtatc 920341 ctgatcaaga cgatggacgt ggcgcacctt acatgtttcg ccatttatct gataatgata 920401 cgcgatcaaa ttagccagtg tgccggtttg cccatcctca ttcggatgcg tcgcgatgcc 920461 agcgggttta ttgatgatga gcatatgatt gtcctcaaat aaaatatcaa gctcgccata 920521 ctccggaatg accgaagatg cttcactttc ctgaagatca atgaacacgc ggtctccctt 920581 ttttacaatc atattgttta agacggattc gtgattgacc tttatctgtt gatgggacat 920641 ccagtcttgt atcactggtt tagaagcttt gagcgctgtt ttgagtacgg aaaacagcca 920701 ttggccgtcc tgtttttcat tgatgaggat ctcaagccct ctgccttttt ggttcatgtt 920761 aaatggctcc ttttcgaagc ggaaggctgc tgtttctcat aggaaacact taccttagct 920821 ttcgcgtttt tttctgtgct attcttgagt aagacttagg atattcgatg gcaagaaagg 920881 tgattgacgt gagaattgtg aacgcagcaa ctgcagaaca ggagagcttt atcaaggagc 920941 tgtctatgga gctgatccat gatgtatttc ctctttattt ctccgaactg gacattcagc 921001 gctttaaaaa gaaaggcgtt ctgtctttaa ataaccatta ttaccaagga acattaaaag 921061 aagcatttca aattatggct tgtctgcaaa tgatacatat tatcctgacc aagccttcgc 921121 cgcactctga tttgagtgat caggcgattt ttgaaaaaaa cagcaagatg ctgaatgatt 921181 ttgggattta ttttccgttt gctttttctg actttcaaaa gaagactaac aaagcctttt 921241 tcggtcaaag aaggctgata taatcatgcg gcaagggctt ttctattttt agaaaagctc 921301 tttttgtatc agagaaatca tatcataaaa cctttcctct aactcccttt ttaaacggct 921361 cgtgtctgaa catactaatg attgaaaggg gtgctgacaa tgagttcagt taaagataca 921421 atgacaacgc aggtggcaac cgtttctccg aatcaaacga ttcaggaagc ggcttctcta 921481 atgaaacagc ataacgtcgg ggcgatcccc gttgtagagc aaggtgtttt aaaaggaatg 921541 ctgactgacc gtgacattgc attaagaact acagctcagg gccgtgatgg ccagacaccc 921601 gtttcagaag tgatgtcaac agaactcgta tcaggaaacc ctaatatgag tctggaagac 921661 gcgtcgcagc tgatggccca gcaccaaatc cgccgccttc ctattgtaga tcaaaacaat 921721 ctagtcggga tcgttgcgct tggagacctg gcagtcaatc agatgtcgaa cgagtctgcg 921781 ggatcagcgc tgacaaacat ttctcaccaa aacattcatt aataagaaag agcttgcagt 921841 gtgcaggctc tttcttcaca taaaacctta ctttttgaaa gcagacttgt ttcggggtat 921901 agtgagtgta tacatatgtc tcaattcgta ctaaaggagt tgtacccagt gattaaagcg 921961 ttaatttttg attttgacgg gcttattcta gatacagaaa cacacgaata tgaggttctt 922021 caggaaatat ttgaagagca cggctcagtg ctgccgctat ctgtctgggg aaaggtcatc 922081 ggaactgctg cgggtttccg gccttttgaa tatttagaag agcagatcgg gaaaaagctg 922141 aaccatgaag agctcacaca attgagaaga gagcggtttg ccaaacgcat ggaatcagaa 922201 aaagcgagac ctggtgtcga agcgtatttg aatgcggcaa aggatttagg cttaaaaata 922261 ggccttgcct ccagctctga ttataaatgg gtgtccggcc atttgaagca aatcggcctg 922321 tttgatgatt ttgaagttat tcaaacggcg gatgatgtgg aagaggtgaa gccgaatcct 922381 gaactctatt tattggcggc aaagaacctg ggggtatcgc cagcggaatg tctcgcgttt 922441 gaggattctg tcaatggttc gattgctgcg aaacgtgcag gcatgaagtg tgtcattgtc 922501 ccgaataaag taacgggtac cttgatgttt gaagactatg atcacaggct tgaatcaatg 922561 gcggagatgg agctcgccct attgcttgat catctgaact cacaaaacta gaaaggagcg 922621 agtaggttgt ctgagaaatt agatttgacc cggtttgaaa agaaaatggt tatccgcaat 922681 atcgaagaga aagacatcga caagattatc gatcttcaaa aggactgctt tccaggaatg 922741 gagccttgga agcgggagca tttaatcagc catttggagc attttccgga aggacagttt 922801 tgtgcagaat tcgaaggtga aattatcggt tcgtgctcaa gtctcctgat taactttgat 922861 gaatatgatg accgccatac gtggcaggac attacagatg acggttatat caccaaccat 922921 aatcctgacg gcttgaatat gtacggaatt gaagtcatgg tgcacccgaa atacagacga 922981 atgaagatcg gccaccgttt gtacgaggcg agaaaggact tagccagacg cttaaacctg 923041 aaaagcatca tcataggcgg acggattcca aactatcaca aatatgcaga ggaaatgaca 923101 gcgagagagt atgttgaaca ggtgacacgc caccaaattt acgatccggt tctttctttt 923161 cagctgatga acggctttac ccttatgcga attaacccga actatctccc ggatgataca 923221 gcttcgatca agtatgcgac gctgatggaa tggaataatg tcgattatct accgcagcag 923281 acaaaacgct attataaatc ggcgttccct gttagaattt gtgtgatcca atacgaaatg 923341 aagaaaattt attcctttga ggaatttgcg aatcaagtag aatactatgt cgatgttgct 923401 tccgacgcaa gatctgattt tgcggtgttc ccggaaattt tcacaaccca gctgatgtcc 923461 ttccttgagg aacggtcacc gagcttggcg gtgcagagaa ttaccgagta tacagaagat 923521 tacatcagcc tgtttactga cttggctgtg aagtataacg tcaacattat cggcggatct 923581 catttcgtcg aagaggaagg caagatctat aatatcgctt acctgttcag acgggacgga 923641 acgatcgaga agcaatacaa actccatatt acgccgaatg aacgcaaatg gtgggggatc 923701 agcgcaggag accaagttcg cgtgtttgat acggactgcg ggaaaatcgc gatccagatc 923761 tgttatgaca ttgaatttcc tgagcttgcc cggattgcgg ctgataaagg agccaaaatc 923821 atctttacgc cattttgtac agaagaccgt caaggctatc tgcgtgtcag atactgttcg 923881 caggctagag cggttgaaaa tcaaatttat acggttatct ctggaacggt cggaaacctt 923941 ccgcaaacgg aaaacatgga tatccaatac gcccagtcag gcatctttgc cccgtctgat 924001 tttgaattcg cccgagacgg cattgtcggc gaaacaaacc cgaatattga aatggtcgtc 924061 atcggcgatg ttgacctgga aattctcaga agacagcgcc aaaacggtac agtgcgccag 924121 ctaaaagaca gacgacgtga tatttatcat attcaatata aaaaataatt cccaaaaaac 924181 ccgcctgaat tggcgggttt ttttaaacaa aagcggaatt gtttaggtgc tttctttaaa 924241 ataaaagtaa attgtatagt ggatgtgcct tatggagttt ctgtattttc gccatttcct 924301 atatcataca gaaaacggct aggcttcaca ttgctattgc aatggctgtc caagttgttt 924361 cgagtgcgac ctttatcagt acgatgctga gcattgtcac tttgcctgtt ttgctttgga 924421 agctgcatcc tctttcttct tgagaaaggg gatgttttat tatttacgcg gtttattgac 924481 tctgacccgg tctggcttta tattgaaggc agggaaatca tcaccaagac atcacataaa 924541 gagaaggtct gtttcaattg aattggcatt atagggaacg ctaatgaaat ggagatgatg 924601 gggatggaaa acattcagca aaatcaggga ttaaagcaaa aagatgagca atttgtgtgg 924661 catgccatga agggagcgca tcaagcggac agcctgatag cccagaaggc cgaaggggcc 924721 tgggtaaccg acacagacgg acgccgctat ttggatgcga tgtccggttt gtggtgcgtc 924781 aacattggtt acggcagaaa ggagcttgcg gaggctgcct atgagcaact aaaggagctg 924841 ccttactacc cgttaacgca aagtcacgca cccgcaattc aactggcgga aaagctgaat 924901 gaatggcttg gcggcgatta tgttattttt ttttccaaca gcggatcgga agcaaacgaa 924961 actgctttta aaattgcccg ccagtaccat ctgcaaaacg gcgaccacag ccgttataaa 925021 ttcatctcaa gatatcgggc ataccacggc aatacattgg gagcgctctc agctaccgga 925081 caggcgcagc ggaaatataa atacgagcct ttgagccaag ggttcctgca tgcagctccg 925141 ccagatatat accggaatcc tgatgatgca gacacgcttg aaagcgcaaa tgaaatcgac 925201 cgcatcatga catgggaatt aagcgaaacg attgccgggg tcattatgga gcccatcatt 925261 acaggcggag gcatcctaat gccgccggac ggatatatga agaaggtgga ggacatttgc 925321 cggcgccacg gagccctttt gatttgcgat gaagtgatct gcgggtttgg acggacaggt 925381 gagccgttcg ggtttatgca ctacggtgtg aagcctgata tcattacgat ggcaaaggga 925441 atcacaagcg cgtatctgcc attgtcagcg actgctgtga aacgggacat tttcgaagcg 925501 tatcaggggg aagctcctta tgaccgtttc cgccacgtga acacgttcgg cggaagcccg 925561 gctgcctgtg ctttggcgtt gaaaaacctg caaattatgg aggacgaaca gctgattcag 925621 cgatcccgtg atcttggagc aaagctttta ggtgagcttc aagctctgag agaacacccg 925681 gcagtcgggg atgttagagg aaaagggctg ctgatcggaa tcgaactcgt caaagacaaa 925741 ttgactaaag agccggctga tgccgccaaa gtaaaccaag tggttgcggc gtgcaaagaa 925801 aaagggctga tcatcggcaa aaacggcgat acagtcgccg gctacaacaa tgtcatccag 925861 cttgcgccgc cattttgcct gacagaagag gacctttcct ttatcgtgaa aacggtgaaa 925921 gaaagctttc aaacgatata atataaaagt gaattattaa aggagcacat gatgagtttt 925981 cacaaccagc cgatcttacc ggctattcgc aatatgaagc aatttgatga gtttttgaac 926041 agttcattct cttacggtgt tattcttgat attcatctcg gccagctgaa gggcgtgatc 926101 aaagaagcgc aaaagcacgg aaagaacatg atggtgcacg tcgatctcat tcaagggatt 926161 aagcatgacg aatacggtgc ggaatttata tgtcaggata tcaagcccgc tgggattatt 926221 tccacaagat cgaatgtgat tgccaaagcg aagcagaaga aaatttatgc cattcagcgc 926281 ctgtttttgc ttgatacaag cgcgatggag aaaagcatgg agtttatcgg caagcataag 926341 cctgacttca tcgaagtgct tcccggcatc gttccgtcac tcattcagga aataaaagag 926401 aaaacaggga ttcccatctt tgccgggggt ttcatccgta cggaagagga tgtagagcag 926461 gcattgaaag cgggggctgt agctgtcaca acatctaata ccaaattgtg gaaaaaatat 926521 gaaaactttt tgacggaaag tgattgacac cgctttcatg cactgataca attgcactag 926581 gttaatacat tgtgatggag aactcggaga ccacagcagc tctttacggc aaatgtttat 926641 gcacccgtaa agcggtttgt tgtggttttt ttattctctt cttctctatc atgcttttta 926701 atcgtgactt taggaggaat gtgctatgac agcattttgg ggagaagtca tcggtacgat 926761 gctgcttatc atttttggtg caggtgtttg tgcaggtgtc aatttaaaga aatcgctttc 926821 attccagtct ggctggattg ttgttgtatt tggatgggga ttgggtgttg ccatggcggc 926881 atacgcggtt ggcggcatca gcggtgccca tttgaatccg gcgctaacga tagcgcttgc 926941 atttgtagga gattttcctt ggaaagaggt tccggtttat attgcggcgc aaatgatcgg 927001 agcgatcatc ggtgcggtga ttatttatct gcattacctc ccgcactgga agtcaacgga 927061 tgatcccgct gccaagctgg gtgttttctc aacagggccc agcattccgc atacatttgc 927121 aaacgtttta agcgaagtga ttgggacatt tgtccttgta cttggaatct tggccatagg 927181 tgcaaatcaa tttacagaag gacttaatcc tttaatcgtc ggtttcctca ttgtagcaat 927241 cggtatttct ctgggaggca ccaccggcta tgctatcaat cctgcacgtg acttaggtcc 927301 gcggatcgcc cacgcttttc ttccgattcc ggggaagggc tcatcaaact ggaaatacgc 927361 atgggttccg gtagtcggcc cgattttagg cggatcattc ggcggtgtat tttacaacgc 927421 tgcatttaaa gggcacatca caagcagctt ctggattgta agcgttatat tggttgtggt 927481 attgttagga ctctatgttt atacgaaatc acattctgct aaaacattat caaattctaa 927541 atatatttaa tcaaagggga gacatcttat ggaaacgtac attttatcct tagatcaggg 927601 gacgacaagt tcaagagcga ttctgtttaa taaagaaggc aaaattgtcc actctgctca 927661 aaaggaattt acacaatact tcccgcatcc tggctgggtt gagcataatg ccaatgaaat 927721 ttggggctct gtcctcgcgg ttatcgcctc agtcatctct gaatcaggaa tcagcgcttc 927781 tcaaattgcc ggcatcggca tcacgaacca gcgcgagacg acggttgtgt gggataaaga 927841 tacaggaagt cctgtctata atgcaatcgt ttggcagtcc agacagacgt ccggcatttg 927901 tgaggaactt cgtgaaaaag gatataatga taaattcaga gaaaaaacag ggcttttaat 927961 cgatccttac ttctccggca cgaaggtgaa gtggatttta gacaatgtgg aaggcgcaag 928021 agaaaaagcg gaaaaaggcg agctgctgtt tggaacgatt gatacgtggc tcatttggaa 928081 aatgtcaggc ggaaaagcgc atgtgaccga ttactccaat gcctcaagaa cactgatgtt 928141 taatatttac gatttaaaat gggacgatga actgctcgac attctaggcg taccgaaatc 928201 catgctccct gaagtgaagc cgtcctctca tgtgtatgcg gagactgttg attatcactt 928261 cttcggaaaa aatatcccga ttgctggagc ggcaggcgac cagcagtccg cattgttcgg 928321 ccaggcatgc tttgaagaag gcatggggaa aaacacttac ggcacaggat gtttcatgct 928381 gatgaatacc ggggaaaaag caattaagtc cgaacatggg cttttgacaa caatcgcttg 928441 gggcattgac ggaaaagtga actatgcgtt agaagggagc atttttgtcg caggctctgc 928501 catccagtgg cttagagacg gtttgagaat gttccaggat tcatcgctaa gcgaatctta 928561 tgcagaaaaa gtggattcaa ctgacggcgt gtatgttgtt ccagcatttg tcggactggg 928621 aacgccttac tgggacagcg atgtgcgcgg ttcggttttc ggcctgacaa gagggacaac 928681 aaaagagcac tttatccgtg cgacactgga gtcattggct tatcagacca aagatgtgct 928741 tgacgcaatg gaagcagatt caaacatttc attaaagacg ctccgtgtag acggaggagc 928801 tgtaaaaaac aatttcctaa tgcagttcca aggagacctg ttgaatgttc ctgtggagcg 928861 cccggaaatt aatgaaacga ctgcacttgg cgcggcttat ttggcgggta tcgctgtggg 928921 attctggaag gaccgttctg aaatcgcgaa ccagtggaat ctggataaac ggtttgagcc 928981 tgaattggaa gaagaaaaac gaaatgagct gtataaaggc tggcaaaaag ccgtgaaagc 929041 agctatggct tttaaataaa gtaatactat ggtataatgg ttacaagtta ataagaacgg 929101 tcctgagatg aggagagacc acagcaccaa agtgtaagca tgcactttgg ctgttgtggt 929161 ctctttttct atttaccgtg acaacaagga ggaaacgtaa tgatgaatca tcaattttca 929221 agtcttgaaa gagatcgcat gctgacagac atgacgaaaa aaacatatga cctatttatt 929281 atcggaggag gaattacagg agccggaaca gctcttgacg cggcatcaag gggaatgaag 929341 gtcgcactaa gcgaaatgca ggactttgcg gcgggaacat caagccgatc aacgaagctg 929401 gtacatggcg gcttgcgcta tttaaaacaa tttgaagtga aaatggtcgc tgaggtagga 929461 aaagagcggg cgattgtgta tgaaaacggc ccgcatgtca ctacaccgga atggatgctg 929521 cttccgtttc ataaaggcgg cacattcggt tcatttacaa catctattgg gttaagggtt 929581 tatgacttcc ttgcaggtgt gaaaaagtca gaacgaagaa gcatgctttc agcaaaagaa 929641 acgctgcaaa aagagccttt ggtgaaaaaa gacggcttaa aaggcggcgg gtactatgtg 929701 gaataccgca ctgacgatgc gagactgacc atcgaagtca tgaaggaagc ggttaaattc 929761 ggggcagagc ctgtgaatta ctccaaagtg aaggagcttc tttacgaaaa aggcaaagcc 929821 gtcggcgtat taattgaaga tgtgctgaca aagaaagaat ataaagtgta tgcgaaaaaa 929881 attgtcaatg ctacaggccc ttgggtcgat cagctcagag aaaaagacca ttcgaaaaac 929941 ggaaagcatt tgcagcatac aaaaggcatt caccttgtat ttgaccagtc tgtctttccg 930001 ctgaaacagg ctgtatattt cgatacacct gatggccgga tggtatttgc gattcctcgt 930061 gaaggcaaaa catacgtggg aacaacagac actgtttaca aagaggcgct ggagcatccg 930121 cggatgacaa cggaggatcg tgattatgtc atcaaatcaa tcaattacat gttcccggaa 930181 ctgaatatca ctgcgaatga catcgaatcc agctgggcgg ggctgcgtcc gctgattcat 930241 gaagaaggca aagatccttc tgaaatttca cggaaagacg agatttggac atctgactca 930301 ggcctgatca ccattgccgg cggaaaactg actggataca gaaaaatggc ggagcacatc 930361 gttgatcttg tccgtgatcg cttaaaagaa gagggcgaaa aggattttgg accatgtaaa 930421 acgaaaaaca tgccaatctc tggcgggcac gtcggcggtt cgaaaaatct tatgtccttc 930481 gttaccgcga aaacaaaaga aggaattgca gccggtttat cagaaaaaga cgcaaaacag 930541 cttgcgatca gatacggctc taacgtagat cgcgtctttg accgggtaga agcgctgaaa 930601 gatgaggccg cgaaacgcaa cattccggtt catattcttg ctgaggcaga atacagtata 930661 gaagaagaga tgactgcaac ccctgctgac ttctttgtcc gcagaacggg acgtttattt 930721 tttgatatca attgggtaag aacatataaa gatgccgtta ttgattttat gagcgagcga 930781 ttccaatggg atgagcaggc gaaaaacaaa catacagaaa acctcaacaa gcttttacac 930841 gatgcggtcg taccgcttga gcaataaatc ataacgggct gtctgcagcc cgttatttct 930901 ttttacgtgc cgaaaggggg agatctcagg ttatcaagtg acagaggcac ccgcttcata 930961 taaaataatg gcataagctg atacatagga ggacgaatat gacttggaga aagagctatg 931021 aacgctggaa acagacagaa catttagatc tggaattaaa agagcgcctt attgaattag 931081 agggagatga acaggccctt gaggactgtt tctataaaga ccttgaattc ggtaccggcg 931141 gaatgcgcgg ggaaatcggc gccgggacaa atcggatgaa tatttacact gtgcgcaaag 931201 catcggccgg gtttgcggca tacatctcga agcaaggtga ggaagcgaaa aaacggggcg 931261 ttgtcattgc ttatgattcc cgccataagt ctccggagtt cgcgatggaa gcggcaaaaa 931321 cacttgcgac acaaggcatc caaacatacg tgtttgatga gcttcgcccg acgccagagc 931381 tgtcattcgc tgttagacag ctgaacgctt atggtggaat tgtggtaacg gcaagccata 931441 acccgcctga atataacggc tacaaagtat acggggatga tggcggccag ctgcctccaa 931501 aggaagcgga catcgtcatt gagcaggtaa acgcgattga aaatgagctg acgatcacag 931561 tggacgaaga aaataagtta aaagaaaaag gcttaatcaa aatcatcggt gaagatattg 931621 ataaagttta tacagaaaaa ctgacgtcca tttctgtaca tcctgaatta tcggaagaag 931681 tagatgtaaa ggttgttttc acaccgctgc atggaactgc aaataaaccg gtcagacgcg 931741 gtcttgaagc actcggctac aaaaatgtaa cggttgtcaa agaacaggaa ctgccggatt 931801 caaacttctc cactgttaca tcgccgaacc cggaagagca tgcggcattc gaatatgcca 931861 ttaagcttgg ggaggagcag aatgcagata ttctcatcgc gacagatcct gatgctgacc 931921 gcctcggcat cgcggtgaaa aacgatcaag gcaaatatac agtgctgaca ggaaaccaaa 931981 ccggagcgtt gctgcttcat tacctgcttt ctgaaaagaa aaaacaaggc atcctgcctg 932041 ataacggtgt tgttctcaaa acgatcgtca caagcgaaat cggccgtgct gtagcttctt 932101 cattcggcct tgatacgatt gatacgctga caggctttaa gtttatcggt gaaaagatta 932161 aggaatacga agcatcaggc cagtatacct tccaattcgg ttatgaagag agctacggtt 932221 atttaatcgg ggattttgcc cgcgataagg acgccattca ggctgcgctt ttggcagttg 932281 aagtttgcgc gttctataaa aaacagggaa tgtcattgta tgaggcgctc atcaatctct 932341 ttaacgaata tggtttttat cgtgaagggc tgaaatccct gacgctgaaa ggcaaacaag 932401 gagcagagca aattgaagcg attcttgctt ccttcagaca aaatccgccg cagaaaatgg 932461 cgggcaaaca ggttgtcaca gcagaagatt acgctgtaag caaacggacg cttctgactg 932521 aaagcaaaga agaagccatc gacttgccaa aatcaaatgt attgaaatac ttcctggaag 932581 acgggtcttg gttctgtctc cgtccttctg gaactgagcc gaaggttaaa ttttatttcg 932641 ccgtaaaagg gtcatctttg gaagacagtg aaaagcgact tgccgtcctt tctgaagatg 932701 taatgaagac ggtggatgaa attgttgagt caacagcaaa ataattcaag tatgagctgg 932761 gtcattgtaa atgatccggc tttttctttt tctcatccaa aagtctgaaa gaaaatcatc 932821 ctacaagtga agcaatgaaa tacaaaaaac tggtataatc ttaaatacaa gatcaatgcc 932881 ggagtgagaa acgtgagcaa aacgaggatg gaaaaattaa aaacgctgaa aacgattgcg 932941 gaaaccttaa atcaagggca cgatatcaaa gcaacactgg atgaggtttt aaaagagttg 933001 ctgagtctga caaaccttca atccggatgg atttttctga tcgaagaaga tgggtcttat 933061 acgttagcgg ccgacgctta tctgcccccg gctttaagcc gcaaggaaaa agtgctgatg 933121 tgcgaagggg agtgttactg cctgacgaaa ttcaataacg gagggcttag aaaagctgca 933181 aatatcatga actgcaaacg catcgaatca gcagaaaacc tgcattgttt tgacacagaa 933241 gggattacgc atcatgcaac tgtgccttta gaagacgggg acagaagatt cggattgtta 933301 aatgtagcgg cggccggaaa aaccatgttt gatgaggaag agctgcattt actcgagtct 933361 gtcgcctttc agatcggaac ggcaatccag cgtatgaggc tttctgaata tcaacaaaaa 933421 aatgctcttt taatggagcg taaccgcctc gctcaggagc ttcacgattc agtcaatcaa 933481 atgctgtttt ccgtcagttt aactgccaaa gctgcgaaga cactaacaaa agatgaaaat 933541 ttacagcaga tgattgattt catccaaaac ctatcacagg acgcgctcgc agaaatgaaa 933601 gcgttaattt ggcagcttcg ccccggagga ttggaaaaag ggctggctga agccattaaa 933661 agctatggtg cgctcattgg attgaagatc atttttacac aaaaaggctg tcctgttctg 933721 actgatgagc aggagcatat gctatggcgt gtcgtacagg aagctttaaa taactgcaaa 933781 aagcatgccg gaacggatac ggcgtatgtt agtctgactg cttctttgtg ccatgcggag 933841 ctggatatca tcgatcatgg ggcaggattt cgctatgaag cgcatgccgg tctgccttca 933901 cttggcataa aaggtatgaa agagcgagcg gaaaaagccg gagctaagtt ttggattgag 933961 tcagcgcttg gaactggaac aaagctgtcc atcaggcttc cgctaaaaag ccgaaaagga 934021 ggggcggtat gaaaattgtc attgctgatg atcatcatgt tgtcagaaag ggtctgcgtt 934081 ttttctttgc cacccaggat gatattgaag tcgtcggaga agctgcaact ggattagaag 934141 ccctccgtgt catcgaagag acaaagccgg atcttgtgct aatggatttg tctatgcccg 934201 agatggacgg cattcaagcc attaaaaaag caatacagca atttccggat acgaatatca 934261 ttgtgctgac gagctactct gatcaggagc acgtcatccc cgcgcttcag gcaggcgcga 934321 aggcgtatca attaaaggat acggagcccg aggaattggt gaaaacacga caagtgcatg 934381 gtggcgaata caagctttct acagctatta tgccccatgt gctgacacat atgaaaaatc 934441 agcacgaccc ggaaaaagaa aaatactatc aattaactag aagggaaaaa gacgttctga 934501 ctgaaatagc gaacgggaaa agcaataaag aaatcgcagc agccttgttt atttcagaaa 934561 aaacagtaaa aacccatgta tcgaatcttt tagcaaaact tgaagtggcc gatcgcacgc 934621 aagcagcgct tttcgcagtg aaatataacc tgaatggaga gatctcaaaa tgaacatgtt 934681 agtcataaat ggcacgccaa gaaaacatgg cagaacaaga attgcagcat cctatattgc 934741 agctctgtat cacacggatt tgattgatct aagcgagttt gtattgcccg tttttaacgg 934801 tgaagcggaa caatctgaac tgttgaaagt acaggagctt aagcaacgcg ttacgaaagc 934861 ggatgcgatt gtattattat cgcctgaata tcacagcggc atgagcggcg ctttaaaaaa 934921 tgccttggat tttctaagca gcgaacaatt caaatataag cccgttgcat tattggcagt 934981 agcgggaggc ggaaaaggcg gcatcaatgc gctgaacaat atgagaactg tgatgcgggg 935041 tgtctacgcc aatgtcattc cgaagcagct ggtgcttgat ccggtgcata ttgatgttga 935101 aaatgctaca gtggctgaaa acattaagga aagcataaaa gagcttgtcg aagaactcag 935161 catgttcgca aaagcaggaa atcccggcgt ctaaacgccg ggatttgttt atgtgagaag 935221 ggctatttga tcttcataag tcagctctgt ggcatgatca atatatcgga gaagggaata 935281 cagcatcttt tctaaaacgg cgtaatcctg ttcaaaatga tacgcatgca gaaaatgctc 935341 aattcgtttt gataacaaat cgtcctctgt acgcaccatt aaaattaata aattatccca 935401 ttgagaacga tgggtgtaat aaagcgcttt atcgtaatcg gcataatcca tgaatcgctt 935461 ctcctttctt gggtgagaag ttcatgatta gtttatgccg catcctctgt tattgacggg 935521 gcaaaacttg ccgtctgcgt cagtaaaggg gtagcaatat gagggagaca taaaatcaaa 935581 atgcctgaat gaagatatcg cttttggtaa acctatgagg gaatatattc tgggtacagg 935641 agactgaaaa aatgaaatcc ctgccgtata ccatcgcact tcttttttgc ggattgatta 935701 tcgtgtcaat ggctgcaaaa ggtcattcaa cggacacaga cgagtccgtt caaaagtggg 935761 aacagcttgc ctggagcaaa attcaggatg aatataaggg cgcttcattt tctgattatg 935821 cttatatggg gcgtacagag gtgaatgatc agcagactaa agatgtcttt cgggtgacag 935881 tcagacagaa agatgacact ttttctgttc gggccgaagt ctattttcat ccggtgacaa 935941 atcatatgat cagcatcaac gtctttaggc tctaataaaa aactgtacag ccgttaaggc 936001 cgcacagttt ctgtttttag aaatatcgtt ttgcaccgag atagcgctgt ttccagtaag 936061 agttgttcat attggaaatg acaactccgg aatcgttggc atttatgaat tccccgttgc 936121 ctaggtaaat tccgacgtgg gaagggccgg ctttatatgt tgaaaagaaa acgaaatctc 936181 cgacagcagg ctggctaact gatttcattg tgttccaata tcccgctgcc gttaatctag 936241 atacggatgt gactttgttc agtacatagt aaatgaatcc gctgcagtca aacccggacg 936301 gtgtcgtgcc tccccagcga tacggaaccc caagctgcgc tttagcggcc gaaatcattg 936361 tgttaatctt cgcactcgtt gagctggtgg tgtttgaaga accggatgaa gacgatgatg 936421 aagcttttcc ggaaatgacc agcttttggc caacctgcaa gacatccgtt tttaaattgt 936481 ttttctcacg aatctgctga gctgttacat taaatttttg agcaatcacc cataaggaat 936541 caccgctttt caccgtgtat gtagtcgtcg tgccggagct tgcatttgac gaagaagacg 936601 acgatgatga agagcctgaa gatgctttac ctgtcagctt caatacttgt ccaacgtaaa 936661 gcacatctga tttcagattg ttgatatttc ggatttgctg tacagtcagg ttatagttgt 936721 ttgcgatttt ccaaagtgaa tcaccgcttt taacggtata tttagttgtt gctgaagttt 936781 ggttcgattt ggatgaattg tctttagaag acgtatcaga gccgcttgat tttgttttca 936841 acacctgatt cacgtaaatg gtgtctgatt ttaagttgtt caagaccttc aattcagcga 936901 tggacatatt gactttgttt gcaattttcc aaagtgaatc tccaagctgc accttatatg 936961 ttcccgtaga agatgaagaa cttgaactct tattagaact gctttttgaa ctggagcttg 937021 aactcttatt agagttgctt tttttactgg aactagagct tgaagaaaca gtaccggaca 937081 cctttaattt ctgcccagca cgaattaaat cgctgcttag tccgtttaat tttttcagtt 937141 cctgcaccgt cattttaaac tcatttgcga tcagccaaag tgaatctccg cttttcactg 937201 tgtaaacaga acttccgctc ttcttggttg ttgagcttga agtagatgaa gaagtgctgg 937261 atttgctgcc tggaatagta agcgtctggc cgatcgacag aacagtagtc gaaagatgat 937321 tggcggatgt gagggccgcc acacttgtgt tataggtttg ggccagtttc cataaagaat 937381 ctccgctttt gaccttaatc gttgctgctt cagctggtgt cactactaaa gttgtgccga 937441 caatcgcaga tgctgtcagc cctgctgcta atttcttttt catcttagct ctcctttttc 937501 ccccaatgat tttgcatttg ctgtttcttt tttatatcgg cacatttgtc tcatcgtttt 937561 gcctttttat aaaaatagcc aaattatctt aacaataagg gggaaaaagg gcataaaaaa 937621 agaaggaatc ttaatctatt ccttcatttt taaaagcttc atgatatctt ctttgttttt 937681 gacgaggtcg cgcagtgtgt atttgtctaa aactgcgagg taggctaaaa gcgcttcatt 937741 cagcacatgt tttaagccgc aaaccgggga aataacacag agattcttgt tcgcatcaaa 937801 acattcaaca atattaaaat cgtcctccgt ttttctgaca acctcaccga tgttgatgtc 937861 ttcagggtcc atgcctaatc gtatgccgcc gccccgtccg cgtatcgttt ctacgtagcc 937921 gagctggccg agcctgtata tgactttcat gagatgattt tttgaaatag aatacgtttc 937981 ggcaatctgt tttatatttg aaagttctcc gggacgctct gcagccagaa aaatcaacac 938041 tcttaatgaa taatctgtat aattggttaa cttcataata agacctcaga ataagacatt 938101 ttctatatct tatcataatc gattgaaaaa tgaaaaaaaa ggaattaaaa aacatgcacc 938161 cagctgggtg catgtttttt gcttacatgt cattcggcgg attttggttt ttacggtttt 938221 tttcgatttc tgtgttttgc attttgcgtt caaatgtaga cagataacgt gatgcaaaat 938281 ccttaccgcc aaggccgaag gataaaccaa aagcaagtgc gaagccgcta agaacgatga 938341 tgaacgcgga attgacgatt gtcgcagcga cacccagctg atccagggcc ataaagaaag 938401 caagtgcgat aatcgtatat ttagcaatag gcgctaaaga cttgaattcc tgacctttta 938461 tcatgcttgc gagcactttt ctcaccaatt ctcctgcgta aaggccgagt ccgagaatga 938521 atactgcgac aaggacattc ggcagatacg cgatgatgcc ggtggcaatt tctacgagga 938581 agtgcagccg aacaatttga agcgcctcag ctgtaaagag cagaatgaca atgatttgcg 938641 caatcatacc gacaacttga gacaaggaca gctttgcagg cgttccggct tccatgccca 938701 ttttccctaa gacagaatca aagcctgcgc gatggagcag tccggacacc atggatttca 938761 cccattttcc tgcccagata cccgctaata caagcacgat ggcaatcatg atgttcggaa 938821 gcatgtttaa aatcgtattc agcatagaga cagctggttt tgaaatgccg gcgacatcca 938881 gctgatcaag cgctgaaatg accaccggaa tcataatgag cacataagcg attgttccga 938941 tgactgctga aaggcttgtg tcttttaagt aaattgataa acccatacgt gccgcgaatc 939001 tttcggtgcc gatgcttgca aggaaattcg taatgatatc acggacaagg cgggcaacaa 939061 gccatccgat taatacgata agcgccgctg caaataattt cggcagaaaa gcgagcacgc 939121 tttccatcat atttgtaaaa ggacctgaaa tgccgctgat tttcaaagaa gataagaccc 939181 ctggcagaaa aacaagcagc acgagataaa agacaatttg tgaagcggta ttgacagcct 939241 ggtgaatatc ttttccttca gacaccaaat tccacttgcg cagtttgtca ctcgtgttca 939301 gcttcatccc gatttttttg acaaggaagc tcaaaacaga agctgcagcc catcctaaca 939361 gcagaatgag tccggctttc agcacgcttg ggatcgcagc tgcaatcgcc gaaagcatac 939421 tgacaaacgg cgatgccact gttgtcaggt gcaaaatgtt aaagaataaa ataaagacga 939481 tgatcagtgc gataaaataa acgaccttgc ttatgacttt ttccgaggaa tagcgtgaag 939541 gctttttccc agcaaagagc ttgtcgtcga tttttgtttt gctgagtcct ttgtataccg 939601 ctttttcaat gattttagca atagcccagc cgattaataa gacgagtaaa gcaatgatta 939661 cgtttggcag cttactgaga taagaagaaa acacgtctgc tacattcaat tggtatcgct 939721 cctttttcgt agtatggtgt gtgtttaccc acttatccaa taagcaaaca gatgaatgtg 939781 ccgggggaat tttttcttgc ccgagtgaga ctatcatctt ttgtctggcg ggctcataca 939841 ttatagataa gtccaagtag gggggattcg gttgaacgcg gaggagaaga agggattaca 939901 gcgggcaatt gaggaaatta ccgaaattgc aaaaggattc ggccttgatt tctacccgat 939961 gagatatgaa atctgcccgg ctgaaattat ttatacattt ggcgcgtacg ggatgccgac 940021 aagattcagc cactggagct tcggcaagca gtttcacaag atgaagctgc actatgatct 940081 agggttaagt aagatctatg agctggtcat taactcagat ccatgctacg cttttttgct 940141 ggacagcaac tcactgatcc aaaataaatt gattgtcgca cacgttcttg ctcattgcga 940201 tttcttcaaa aacaactgcc gtttccaaaa cacgaagcgc gatatggtgg aaagcatggc 940261 ggcaacagct gaacggataa aacactatga acaggttcac gggataaaag aagtcgaatc 940321 ttttttagat gcaatccttt cgattcagga gcatatcgat ccgtcgttgg tccgaccaaa 940381 gctccaatgg agtgtggatg atgaggaaga ggagattgaa gaggcagcca cgccttacga 940441 tgatctatgg tctttagatg aaaagaaacc gaaaaaacaa gtgaaaaaat cgaaaaaacc 940501 gttcccgccg cggcctgaaa aagatatcct gctttttatc gaggagcatt cccgggagct 940561 ggagccatgg cagcgtgata tattaacgat gatgagagag gaaatgcttt atttctggcc 940621 tcagctggaa accaagatta tgaatgaggg ctgggcttcc tattggcacc agagaattat 940681 acgtgagctt gatttaacct ctgatgaagc gatcgagttc gccaagctga atgcaggtgt 940741 cgttcagccg tccaaaacag gcattaatcc ttattattta gggctgaaaa tatttgaaga 940801 cattgaaaag aggtacaaca acccgacgga ggaaatgaag aaaatgggcg tgcagcctga 940861 ctccggccgg gagaaaatgt ttgaggtcag ggagattgaa tccgatatct ctttcatccg 940921 caattattta accaaagaat tagtcatgcg cgaggatctt tatttgtttc aaaaacaggg 940981 ccgagattat aaaatcatcg ataaacagtg gaagtcggtg cgcgaccagc tcgtaagcat 941041 gcgggtaaat ggcggttttc catatttgac agtaaacgac ggcgattata tgaaaaataa 941101 cgaactctat attaagcatt ggtatgaggg catagagttg gatttgaaat atttggagaa 941161 agtgcttcct tatttattcc agctttgggg aagaagcgtg cacattgagt ctgtgcttga 941221 ggataaggaa gtcatgtttt cgtacgacgg aaaaggtgtt caccgcagat atttataaaa 941281 aagaggatgc agcgttctgc atccttttta ttttccagtt tttaaaatct taaatatgat 941341 gtttgcctgg tccgtattgt taatcaatcc gcggaatttt tcttttccgg ggccgtacgc 941401 gtataccggt acttcttcgc cggtatgatc ggtactcgtc catccgctgt tggagcgggt 941461 attaaaaatc ttgatgatgg ctttggaggc ccctttgctt ttgtcagcct gtgcagctgc 941521 ttcaacgctt ttgatttctt cagatgtgac tttcagattg gcatagcggg cgagcacatc 941581 tttaaccggc ttgccttcac tgattttttt ggccatgaat tcaggtgttt tcttagcgga 941641 gagaatcggt tctgcgtgcc aattcttttc cccgtttgcg ccaatggtaa agccgccggt 941701 tgtatggtca gcagttgcaa tcacaagtgt atgtttgtct tttttcgcaa attcaatcgc 941761 ggctttatag gcctgttcaa aatctttaac ctcgctcatg gctcctactg tatcattgtc 941821 atgggccgcc cagtcaatct ggctcccttc gaccatcaag aaaaatcctt ttttattttg 941881 gttcaggcga tcaattgctg aaaccgtcat gtctttgaga gacggtgttt tactgtcacg 941941 gtcgagcgct ttagcaagcc ctccatctgc gaaaagcccg agcacctgct gatctttatt 942001 ttttttcaat gcttgtttag ttgtcacata gctgtagccg gcttgtttga attcctttgt 942061 caagtttctg tccttgcggt taaaataaga ttttccgccg ccgagcagca cgtctatttt 942121 atgtttgcct tttatcttgt catccatata gctgttggcg atttggtcca tgtttttccg 942181 tgattcattg tgggcgccat atgcggctgg agtggcgtgg ttaatttcag acgtggcgac 942241 aagccctgtt gacttgcctt gctgtttggc ctcttcaagt acagatttca ctttttttcc 942301 gtttttatcg acgccaattg cattgttata tgtcttaacg cctgtcgcta atgctgttcc 942361 ggctgctgct gaatctgtaa tattatagtc agggtcatcc ggatgcgtca tcatcatgcc 942421 tgtcaggttc cggtcaaatt ctgttaactt cgggttattc ggtgtgtcac cgttattttt 942481 catggaacgg taggctctta tgtaaggcgt ccccatgccg tcgcctatca tcacaatgac 942541 atttctgatc tcagctttgt cttgtttttt ggcgctggcc ttttctgttt gctgaagctc 942601 agctccggca aagattccag ctgtaaggac agaaacagcg gcgattggca gaagttttga 942661 tttcatattt tgaaacaaac tcattttttt catgcctcct ttaatgtatt ccgtttatca 942721 tgttagggaa actttgttaa atgcggctgt tgatcatgta aacaataagt aaagccttgt 942781 aaggaaatga aaaaacgctt ttcgttatct tgccttattt gatgtaaagc attcattttt 942841 cagaaaaatc tttacctctc tgtctttgca tgatatgttt gtttaaataa aaaaactgcg 942901 gataaccaca gctctcctcg aatatacttt atcactcatt tttccgatat atgagccgac 942961 cccgaaagtt tttcatttat ttcctttatg ttgaaaaaca tcccataaaa catgacaaaa 943021 gcactcgttt tttgtcacct ttgcaatgaa aatgaaatat ttaataccct taaaaacttt 943081 tttttagaac gaataattaa gaaatttgtc acatgaagtc aagactattt ctgatgggaa 943141 tctatcctta taatagaaat caataagatt aatttaaaaa aagagataca tatatataga 943201 gttaacattt ggggaggaaa atatgaaaaa gcaaatcatt acagctacga cagcagttgt 943261 tttaggatcg acgttatttg caggagcggc atctgcacaa agcattaagg tgaaaaaagg 943321 cgacacgtta tgggatcttt caagaaaata cgacacaacg atcagtaaaa ttaaatcaga 943381 gaaccacctt cgttcagaca ttatttatgt gggacaaact ttatcgatta acggcaaatc 943441 tacaagttca aaaagcagca gttcttcttc ctcttcttct acatacaaag taaagagcgg 943501 ggacagcctt tggaaaattt caaaaaaata cggcatgaca atcaatgaac tgaagaagct 943561 gaatggctta aaatcagatt tgcttcgtgt tggacaagtc ctgaaactga aaggttcaac 943621 tagttcaagc agctccagct catcaaaagt gtcatcgtct tcaacttcta cttataaagt 943681 gaagagcgga gacagccttt ctaaaattgc gagcaaatac ggcactacgg ttagcaaatt 943741 aaaaagctta aacggcttaa aatcagatgt aatctatgtc aaccaagtat tgaaggtgaa 943801 aggaacaagc acaagcagct caaaacctgc ttcatcttca tcgtcttcaa gcagcaaaac 943861 gtcatctaca tcacttaatg tgagcaagct ggtttctgat gcaaaagcgt tagtcggaac 943921 gccatataaa tggggcggaa cgacaacttc aggctttgac tgcagcggat tcatttggta 943981 cgtactgaat aaacaaacaa gtgtgggcag aacaagcact gcaggatact ggagttctat 944041 gaagagcatt gccagcccgt ctgttggtga tttcgtcttc ttcacaacat ataaatccgg 944101 cccttctcac atggggattt acattggaaa caacagtttc attcatgcag gatctgacgg 944161 cgtacaaatc agcagcctga acaacagcta ctggaagcct cgttacctcg gtgcgaaaag 944221 attctaattt ttagagaaaa cccgttcatt ggaacgggtt tttttcatta gacggagcac 944281 aggcgttttg gttgctccta aaaatgaaaa tgtgataaaa aatccaagaa ctttttttct 944341 ttcttatttt cataaagggc aatcgcgtaa gcgccggcat agggcagctg tacagactga 944401 taaggaattc tgatcatctg tttctctgct aactcacgct ttactgtaga taaaggcaga 944461 aatgaaactc cgagtccttc cttgataaac cgtttcgtta tatgtgtttg agtgaccttc 944521 attgttctca caaatggaaa tgtcattctg acttgacgga gcaagtcgtc ccagtaatca 944581 ggatgattgt gggtcaaaag caggtattgt tcgagcacct ctttggcatc aatttcgttg 944641 tcttctatga aacgcttatc gggcggggca acaaggacga cagggtcttt gtataagcag 944701 tggcagctta aagaagaaga ctgtaccttt aaacagctta gtccgatatc tgcttccccg 944761 gctttaatca gtgacgcgat ttccgctgat tcgaaaatcg taaccgccat ttctgtttcc 944821 gtattcattg ctgtgtaccg cttcatgaca gaaggaagca ctgtatctgc aataagcgga 944881 gaaaccgcga gctgtaaggt ttgagagtag ccttgtctca ctctgtgaag ctctgccatg 944941 ctgttttcat aatcatcaag aagcctgagc gcatacggca aatacgccct gccttcatca 945001 gtcagctgga tttgcctgcc tttacgctcg aacagcttgc agctgatttc tttttctaat 945061 tgcttgatat gtacggtcac agtaggctga gataagaaaa gcgtttccgc cgtttttcgg 945121 aagttctcat attttgcagc ggtcacaaag gtgtgaagcc atttgaaatc catttctatt 945181 ctccctctga ttaatatttt taattaattc cctttaaaat attgattatt ttttaaatat 945241 tatatttact ataataacag aaaaggatag ggggaataca aatggtacat tacggattaa 945301 agggaattac atgtgtagaa acatccatca gccatattga tggtgaaaaa gggcgtctga 945361 tttacagagg acatcatgca aaagacatcg cactgaatca cagctttgaa gaagcggctt 945421 atttgatttt atttggaaaa ctgccttcaa ctgaagaatt gcaggtattt aaagataagc 945481 tggctgcgga acggaatctt ccggaacata ttgagcgctt gattcaatca ctgccaaaca 945541 acatggacga tatgtcggtg ctgagaacgg ttgtttcagc attgggggaa aatacgtaca 945601 cattccatcc gaaaacagag gaagcaatcc ggctgattgc aatcacgcct tctatcattg 945661 catacagaaa aagatggacg cgcggtgaac aagcaattgc accttcttcc cagtacggac 945721 atgtcgaaaa ctactattat atgctcacag gtgaacagcc ttcagaggca aaaaagaaag 945781 cgcttgaaac ctatatgatt ctggccacgg agcacggcat gaacgcatcg actttttcgg 945841 cacgagtcac gttatctaca gagagtgatt tagtgtcagc cgtcacggct gctctcggta 945901 cgatgaaagg tccgctgcac ggaggtgctc cttctgcggt gacaaaaatg cttgaagaca 945961 ttggagaaaa ggaacatgct gaagcatatc tgaaagaaaa actcgaaaaa ggagagcgct 946021 tgatgggatt cggccacagg gtgtacaaaa caaaagaccc gcgggcagaa gctttgagac 946081 agaaagcaga agaggtggcc ggcaatgacc gtgatcttga tcttgcgctg catgtagaag 946141 cagaagcgat tcgtttgcta gaaatctaca aaccgggacg aaagctgtac acaaatgttg 946201 aattttacgc agctgcagtg atgagggcca tcgattttga cgatgaattg tttactccga 946261 ccttttcagc aagccgaatg gtagggtggt gcgcccatgt actggaacag gcagaaaaca 946321 acatgatttt ccgcccgtca gcgcaatata ccggtgccat tcccgaggaa gttctttcat 946381 aacatatttt ggcgtttatt catttctgtc gtgtggtaac gttcagtatc aaccacatgt 946441 ctaggagtga tgaatgtgaa cccaatggac agacaaacag aaggacaaga accgcagcat 946501 caggacagac agccgggcat tgagtcaaaa atgaatccgc tgccgctgtc agaggacgag 946561 gattatcgag gaagcggaaa actgaaagga aaagttgcga tcattactgg aggcgacagc 946621 ggaataggga gagcagcagc tattgccttt gctaaagagg gggctgatat ctccattcta 946681 tacttagacg agcattcgga cgcagaggaa acacgcaaac ggatcgaaaa ggagaatgtc 946741 cgctgcctgc ttatcccggg agatgttggg gacgagaacc attgtgaaca agctgtgcag 946801 caaacagtgg accattttgg taaactcgat atcttagtga acaacgccgc tgaacagcat 946861 ccccaggaca gcattctcaa tatttcaaca gaacagctgg aaaaaacctt tcgcacaaat 946921 attttttcca tgtttcatat gacgaagaaa gctttgcctc acctgcaaga ggggtgtgcc 946981 attattaata cgacatcgat taccgcttat gaaggggata cggcgttaat tgattattcc 947041 agcacaaagg gtgcgattgt ttcctttacg cgttccatgg cgaagtcgct tgcagataaa 947101 ggcatcagag tgaatgcggt ggcgcccggt ccgatttgga caccgcttat tccggcgaca 947161 ttccctgagg aaaaagtgaa acagcacggc ttggataccc caatgggaag accgggacag 947221 ccggttgagc atgcaggcgc ctatgttctg ctggcgtctg acgaatcttc ctatatgaca 947281 gggcagacca ttcatgtgaa tggcggccgt tttatttcaa cgtaatcaac gaaaaaccag 947341 ctcaagagct ggttttttgt gtggtgaaaa atttcaaaat aaaaaatttg tcgatttttc 947401 taacaatttt gttttcattt ttgcaatttt atatataata ttgagtagga gaaaggaatg 947461 attcgcgacc agtacaaata tagtagaaaa aaaagaataa tgaccattgt tactcatgaa 947521 ttcagaaaat tcaaataaaa tatataaaaa tagatgatcg ggagttgaag gggaatgaaa 947581 gggagcgttt ttaggaagaa aagcattcag gatttaatcg ctgcgacgag cggggaaaag 947641 tctttaaaaa gagaattagg ggcatttgat ttaacgttgc ttggaatcgg cgccattatt 947701 ggcacaggga tttttgttct gacgggaaca ggcgcagtca cggccggtcc cgggctgacg 947761 atttcatttg ttgtggcggc gttggcttgt ttattcgccg ccctgtctta cgcggaattt 947821 gcgtcaagtg tgcctgtttc aggttcggtg tatacattca cttatgcgac attgggagag 947881 cttatggcct ttattatcgg gtgggattta attttagaat acatgctggc ggtaagtgca 947941 gtgtcggtcg gctggtctgg ttatttccaa tcgtttttat cagggcttgg cattcatctt 948001 ccggttgctt taacagcggc accgggcgca gtgaaaggca cctttaccct gtttaatctt 948061 cctgcattcg tcattgtaat ggcgatcaca tatttgcttt atttaggcat caaagaatca 948121 aaaagagtca acaatatcat ggttatcttg aagatactgg ttgttctgct gtttatcgcg 948181 gtggcagccg tttacgtgaa gccgcacaac tggcagccgt ttatgccaat gggctttggc 948241 ggcgtgttca gtgcagcggc gctcgtattc tttgctttta tcggatttga cgctgtatcc 948301 tctgctgcgg aagaaacgaa aaatcccgcg aaggatctgc ctaaaggcat tattttctct 948361 ttactggtct gcacgatttt atatgtcacc gtatcagcca tcatgactgg ggttatcccg 948421 tttgctcaat ttgcgggtgt ggatcatccg gtttctcttg ttcttcaaag cgcagggcaa 948481 aattgggtgg caggcatcat tgatattggc gccgtgttgg gaatgacaac agttatgctc 948541 gtgatgcttt acgggcagac ccgcgtcatg tttgccatgt cgcgtgacgg acttgtgccg 948601 ggttcacttt ctaaagtgca tccaaagcac aaaacacctt atgtagccac ttggtttttc 948661 ggaacgatgt cggcgcttct cggctcactt gttccgctgg atgaacttgc aaagctggtg 948721 aacatcggga cgttgtcggc atttgtcctg atttctgtgg cagttatcgt tttgagaaag 948781 aaacagcctg atcttccgag agcttttaaa tgcccgggag ttcccgtgat cccaggcctg 948841 gcgattctgt tctgcctgtt cttgatttta aatctgggat gggtgacgat tgtccgcttc 948901 ctagtgtggc tgttaatcgg cttggtaatc tatttcctgt attcaagaaa gcattcaaaa 948961 ttaaatcaat aaccttttga taaagagagc ggccatacag gccgcctctt ttctgttctt 949021 ggcaaatgaa tctatagaaa tgaagacaaa aataagagat aatataggct ggaaaggaag 949081 tgacgtttat tgtctgagca aaaaccagtc caatgggctt cgaaaattgg tttcgtcatg 949141 gcagcggccg gctcggctat cggcttgggc gcgatttgga agttccctta cgtagcgggg 949201 accaatgggg gaggagcctt ttttcttatc ttcgtgttat ttaccatcct cttaggctat 949261 ccgcttttgg tgggggaatt tatttttgga agacggaacc agacgaatgc cattgatgca 949321 tataaaaaag aagcgccgcg atcagcttgg tttcttacgg ggtggatcgg cgtagcggcg 949381 tgtttcttag tgctgtcgtt ttacagtgta atcgggggat ggattttgct gtatatcgtg 949441 aaaacagcgt caggatcact gtccgggctt tctcaagcac agtatggcgc tctttttgct 949501 tctattatcc aaaatccggt gcagacgctc gcggctcagc ttgtctttat ggcactgact 949561 gtactcgttg tcgcaagagg ggttcaaaaa gggattgaac gggtaagcgc ggtgatgatg 949621 ccgattttgt ttttattgtt tattctgctc gttcttcggt ctcttacgct taatggtgca 949681 atggaaggcg taaagtttct gcttgtgcct catttcggcg atctgactcc ggaatccata 949741 ttattcgcgc tgggacaggc cttctttacg ttaacactgg gggtttcggt gatggtgacc 949801 tacagctcct atttgccgaa aacacaaaat atccctcgtt cggcagcctc cattgtcttg 949861 atgaatatca ttgtgacact cttggcaggt ttggctattt ttccggcggt tttctcattc 949921 ggttttcagc caaatgaagg accgacattg ctgtttacag tgcttccggc cgtttttgaa 949981 cagcttccgt tcggcacatt gttttttatc ggctttctcg ttgcattttt atttgcagcc 950041 ttaacctcag cattttcgat ggttgaaatt atcgttgcca caatcggaaa aggggacgaa 950101 aagaagagaa aaaaactgtc atggacgagc gggcttttga tctttttggt cggaatccca 950161 tgctgcttgt cttatggcgt tttgagtgat gtgcacctat ttggcaaaac gttttttgat 950221 attgccgatt ttaccgtcag caatgttttg atgccttcag gcgctctgtt aatttctcta 950281 tttatcccgc tgaaaatttc gaaaagcgaa ctcttggctg aaatgcgaaa tggatcaaat 950341 gcaggtaaag cattctttta cacatggttt tatttgcttc gttttatcgt gccgcttgcc 950401 attattatcg tgttcttaaa tttaatcgga attttatcat tttaaaaaac aggctccgtt 950461 tccggggcct gttttttatt taataagatg atatcaacgg tgcccatgcc gttttcagtt 950521 tttggatgcc gagcctgatg tcctcttctg acaaaccgcc ataaccgatt aagacagaag 950581 taaaaggcgt ctgttctata tatgagggag acacgggata gagggttaca ccgtggtcag 950641 cggctgcttg tattgcttct tcctcacttg ctggaaacaa aaggcgcagc agaatgtgaa 950701 gccccgagtt cttaccgaga atctcaacgg tgtttcccag ttcagagcga atggcttcta 950761 acaggacagc gtgttttttt cggtataagc ttctcattct atttatgtgt ttttgccact 950821 ctccggtttc gatgaagtct gccagtgcca attgcgagtg ggcagaaacg gtctgcttca 950881 ttaactgaac attgttttgg atcggttcca tgagttcagg gggcacaatc atgaagctga 950941 gccgcaagga aggcagaagt gactttgaaa aagtgcccag atatatgact ctgccattcg 951001 gatcaagacc ctgtaaagac ggaatgggat ggccgctgta gcgaaattct ccatcgtaat 951061 catcttctat aatgaatgaa tttgtttctg ccgcccatgc cagcagctcc tgtctgcggg 951121 taatcgtcat aatggtccca atcggaaact gatgcgaagg agtcgtatac atgagataag 951181 gattctgacg gtagagctca tccggcagga cgccttctgc atcagaacaa atcggagtga 951241 catccatgtg atttgcttca aacatccttc ttgaacggtg aaagcccggt tcttcaaagc 951301 cgatttttgt acctggcttt agcgaaaggc aaagattttg cagaagcacg gtggttcctg 951361 cgccgatgat aatctggccg ggttcacaat ttactccccg agacagcctg acgaatcggg 951421 caatcatgtg cctgagttcg tattctcctt gagggtcgcc agaggtgtga aacgatccgg 951481 aatagcgatc aagacttttt actatgcttt ttctccatgc gttaaaggga aagagggtcg 951541 gatcaacgct gccctgatgg aagtcaatag caggtgcgtt tttttgatgt aatcccggct 951601 gtacagactg ctgaaaatgg tcaggagctg tcgggaatcc tggttctact tccgccgcga 951661 accagccgat tttcggcttg cttttgacat agccctcagc agttaattgc tcataagctc 951721 gttctatagt tgccgtgctg acatcgagca agctggagag cctgcgtttt gacggaagtc 951781 ttgttccctt tgtgattcgc gcatgtgaaa tttcttgttt aaaaaaggta taaagctgtt 951841 catacagcgg tgttttgctc tttttatcaa gaaacggcgt aatatccatc tcatgtctcc 951901 tttgtagctg gcatggtcat tttttctgat attggctatt tggcaaatgc catttattag 951961 ctatgatcat tgtaacgaaa ggaaagggga ttgagaagat gatccatatg aaacaattaa 952021 cctcgaaaga agaatgggct gagtcgtatc cgattatgag tgaattgaga acagaactgg 952081 atatagagac gtatttacaa aggcttgaag cctgtgtgca gaaagaatcg tatatgctgt 952141 ttgccttata tgaaaataca gcaatcagag cgctgtgcgg ggctctgccg agagtttcca 952201 ttcataaagg agagcacttg tggattgcgg atcttgttac aacggcacct tgccgatcaa 952261 agggatacgg caaaatgctt ttggattatg cctcagactg ggcgagaaaa gccggactcg 952321 gttttgtcag tctttcatct ggccttcagc gtaaagacgc acatcgattt tatacagata 952381 aaatgggttt tactatagaa agttatttgt tccgaaaacc ggtataacga aaaaagacgc 952441 ctgaaaaggc gtctttttta aaagccaaac tgtaaattcg tatctacaga tacaatggta 952501 tacacacaaa taatcacaaa gagattaagg atgacgccga gcaggcctgg acctgtgcgc 952561 cctctcttga tgaagagttc aacaacgccg aacggaacgg cagccatggc gaacggaagc 952621 atttgatagg aataaaacgt gacgttgctg ataatggcca aattcagcaa cagcagggac 952681 agaaccgctg tcccgacaga gatccagccg aatacattgt gttctttaaa aattcttacc 952741 agttccataa ttccacctcg ccgacattcg ctgattttac agatttattt ttcagcatgc 952801 gctggatttc cttggttggc cctgtaacga ccgaaccgta tacattgaca ccgtttttct 952861 ctacataatc taatcggtta tctacattca ggtctttccg ttttgaaatg acctgagccc 952921 atttttcgtg tttggacatg aatttcaggg cgttgataaa ctgatcgcca ttcgacttgc 952981 cttttgtatt aagggcggcc aagaactttg aatcctttcc aggatagcca agaggttctg 953041 tggaagctgt cttatttgtg tttttctctg tttcgattgc gttccacaaa aagctcacat 953101 catagccttt gaatttgtta tacacgtctt ttgtcggata tgcacggtca tatgaaaggt 953161 agacctctga taccgttcct tcaggcaatg tgcttaacgt tttttctgct tttgcggtcg 953221 tttgttcaga cttgtttgaa ggatgtgtaa agtaatggcc ggttttattc acttctaagt 953281 catagtagtt tactgccggc gcttttactt tgttataaaa catttcaacc cgttcattcc 953341 ctacggcagc cgtcttcgtg ccaatctgct tttgcagcgg gaattccgta ttcattccaa 953401 atagcttcac ttggcttttc agtccggaag tatcaacaag aacattcggc atggtcaggg 953461 ctacagtgac tgcggcagtt tccataaact cattgccggt gctgtgtttt ccacccattc 953521 cgtaatagag gtagcttccc agcgtacaaa gcggcaaaat catcaatgtc gaaatgacgg 953581 caagcacaga aattcgcaaa taagacttgc gtttgccgta ggctaaaatc gctttttgtt 953641 tttcaggact gatgctgaga tcccaatcgt tatcgtcctc tagttcgctg tcaatcagtt 953701 cctgatatac ttcaagcttc tcgagttctt cctcaaatgc agtcatttcc tggtcgctca 953761 tttccccatt tttatattga tcaaaacgct ttttaaattc ttcattcatc attaacacct 953821 ctattataaa gtgctttcag ccgctgtctg gcacgaaata aaacactttt aaaattcgcc 953881 tctgaaatat tcataatatg ggatgcttct ttgtagttta actcttttaa ataatatagc 953941 gttaaggcct cccgataatt atcggggagc tcggacatat aaccagtcag cacttccttt 954001 atctctacct gatgggcagg actttgaaca gcattttgaa agaggcttcc gattaagtca 954061 tcagaaatgg ttacttcttt cttatgcttt ctgacgtaat caatgaaggc gtttcgcgcc 954121 acttgaaaaa gccagggctt tactttgctg tgatcatagg agtgaatgtg tatgtatgcc 954181 cgcataaagg tttcctgcag taagtcttca gcaagatgct tgtcttttgt catggagagc 954241 aggaacctgt aaacatcatt catgtacatt tggtaaattt catcgatcgt cactgccttt 954301 tctcccctct atgttataca cgcataagaa aggtttaaag ttgcacatta catgcaaacg 954361 gcttttttat acctaatcaa acaccattac tatatagtac ccaaaaatgg ccgcaaaaga 954421 tagtgcggag aaaggtttaa cattttttcc agaggggaaa agatagtgaa aaagtgaagg 954481 agtggcacaa tggaatatac cagtatagca gatacaggaa tagaagcctc cagaatcggc 954541 ctcggcacat gggccattgg cggaacgatg tggggaggca ctgacgaaaa aacatcgatt 954601 gaaacaatcc gcgccgctct tgatcagggg attacactga ttgacaccgc accggcttac 954661 ggcttcgggc agtccgagga aattgtcgga aaggcaatca aagagtacgg caaaagagac 954721 caggtgattc tcgcaacgaa aacggctctg gactggaaga acaaccagct gttccgccat 954781 gcgaacagag cgagaattgt agaggaagtt gagaattctt tgaagcggct tcaaacagac 954841 tatattgatc tttatcaggt gcattggccc gatccgcttg tgccaattga agaaacggct 954901 gaagtcatga aggaattata tgatgcggga aaaatccggg cgattggcgt cagcaatttt 954961 tcaattgagc aaatggatac atttcgcgcc gtcgcacctc tccatacgat tcagcctcca 955021 tataatctgt ttgaaagaga gatggaagag agtgtccttc cttatgcgaa agataacaag 955081 ataacaacat tattatacgg cagtttatgc agagggctgt taacaggcaa aatgactgaa 955141 gaatatacat ttgagggcga tgatctgcgt aatcacgatc caaaattcca gaagccccgc 955201 tttaaagagt atctttctgc tgtgaatcaa ttggataagc tggcgaagac acgttatgga 955261 aaatcagtga ttcacttggc tgtcagatgg atcttagatc agccgggagc ggatatcgct 955321 ctttggggag caagaaagcc tgggcagctt gaggccctat ctgagattac aggctggacg 955381 ctgaacagtg aagatcagaa agatatcaat actatattgg aaaatacgat atcagaccct 955441 gtcggaccgg agtttatggc cccgccgacc agagaggaaa tataacaaaa gctgagggcg 955501 aatcctcagc tttttggcgt ttaaacgaga gaaatcttaa aaattagtac caggtaataa 955561 aaaatattgt tataatagat gacagaaaga atcattgatt acgacaaagg aagtgcgata 955621 tgtataagtt ttgtgcaaat gctttaaaag ttattctttc tcttcgcgga ggagtgaagg 955681 tgtataacaa agaaaacctt ccggccgatt caggttttgt catcgcgtgt acacattccg 955741 gctgggttga tgtgattaca ctcggagtcg ggattcttcc ttatcaaata cactacatgg 955801 cgaaaaaaga gctttttcaa aataaatgga tcggttcgtt tctgaagaaa attcatgcct 955861 ttccggtaga tcgggaaaat cccgggccaa gcagtattaa aacgccgatt aagctgctga 955921 aagaaggaga gatcgtcggt atcttcccaa gcggaacaag aacctctgag gatgtgcctt 955981 tgaaaagagg tgcggtgacg attgcgcaaa tggggaaagc gccgcttgtc cccgctgcat 956041 atcagggccc ttcaagcgga aaagaattat tcaaaaaagg aaaaatgaag ctgattatcg 956101 gtgagcctct tcaccaggct gattttgccc acctgccttc aaaggaaaga cttgcagcaa 956161 tgacagaggc tttgaatcag cggattaaag aactagagaa taaacttgat cagctataag 956221 gcgttctgag agattgtcct gaaactgtga aaataagaaa agcaccctat acaaggtgct 956281 tttcttatta tgcttcctgc tggttagctg tctccagaag ttcttcttct tgaagctttt 956341 tcacttcaat atatgcgacg tggtggccgt caatttcatt aatgatgaat tcgcagccct 956401 cttcgatgat ggaatcatct ttttcaacat cgtatttttg agtaaggaac cagccgccga 956461 ttgtatcgac ttcttcgttc tctaaatgga tgcctagcag gtcgtttact tggtcaatta 956521 acacttttcc gtcaagaata taatggcctt cgccgatttt gcggatttcg ctaatttcat 956581 caatatcaaa ttcgtcgcgg atttcaccga caatttcctc aatgatgtcc tcaaccgtca 956641 caagcccggc agtaccgccg tattcatcag acaaaatggc catgtggacc ctctcttttt 956701 gcattttgac aagcaggtct tggatcggcg cagattcaat gacatgaatg atagggttga 956761 cgaattgaga aatggtggaa tcaacagata cctcaccgct gatgcaggcg gtcagcactt 956821 ctttaatgtt aataaccccg ataatgttat ctttatcgcc ctcttccaca gggtagcggg 956881 tatatttttc aatctgaatg atgtccatca tttcagaaat cttgatatca tgcggaaggc 956941 tgacaatttc ggtccgcgga atcataattt ctttcgcgag cctgtcgtca aattcaaaga 957001 ttttattcac atatttaaac tctgattggt tgatttcacc gcttttatag ctttcagaca 957061 aaatgattcg cagctcttct tctgagtgag ccagttcgtt ttctgaaacg gtctccaggc 957121 caaatgcttt ggtcaataac cgtgcggaat tgttcaaaag ccaaatgaat gggaacgcga 957181 tgcggtaaaa ccaaatcagc ggtttcgcaa acagcataga cactgcttcc gccttttgga 957241 tagcgactgt tttaggtgca agttctccga caacaacgtg taagaacgtg ataatggcat 957301 acgcaaaaat aaacgatatg acatgtgaaa gggaacctgg aacgttcatt tggacgaaaa 957361 gcgggtgaag cagcctttcg atcgttgatt cacctaaaac ccctaatccg atggaagtca 957421 atgtaattcc gagctgacac gcagataaat attcatcaag atgcgtggtc acttttttta 957481 cggctattgc tgctttattt ccttccgcga tcagctgatc gatccgtgag cctctgattc 957541 tgataatggc aaactcagat gccacgaaaa atgccgtcag ggcgattaaa acagcaacta 957601 aaatcaaatt cactatgtcc aattagaacc ttcactctag caatgagaat gaaggtaaca 957661 cctcctgtta gataaaatgg ttttaactta acagcagcat aaatgattgg aacacggcga 957721 gcttttcagg cgggagtttg cttttcagct tgtcacgatc ctcgggcttc agccgttcaa 957781 accgatgcaa gattccggag atgttttgat tcatatgatc aatttctaat gccagatttc 957841 caatttcatc atcaagttta gctgaagagg gaaactggtt ctccagtcga tctttaatat 957901 cggacagggc caatcgctgc ttcttgcaat ctacaataaa tataagtcgt ttgagtgcat 957961 tttcgtcgta gtaacggtaa tttgaacagg atctggccgg cgtaagcaga ccgagattcg 958021 tataataatc aactgtccgt ttcgttactc cggcgagtgc cgctagttca ctgatgcgat 958081 aagtctcagc cccatctata tccctcccaa ccatcacgtt atagttatga gaatagttta 958141 atatatgaac ggtgtcttgc acaagtttat tgtttttttt agaccggaat tggaagttgt 958201 ggaattcatc atctgattga agtaacatag gaagatagaa ttttcaaatt tttatatgcg 958261 gaagggacag atgaaattgg ctgggttatc ccgggaagtt gaagaaaact taaataaagg 958321 atcatggatt cgcaagctgt ttgatgaagg tgcaaggctg aagaaggagt tcggggaaga 958381 ccaggtattt gatttttcac tcggcaaccc gattgttgaa ccgcctgaag cttttaagag 958441 agcgttaata gaggaagctg aaaaaggcag ccacggatac atacaaaacc aagggcttct 958501 tgcagcgaga gaaaaagtcg cgcaatttct gggctcgcgt tttgaagctg atttctcagc 958561 ggagcgcatc gtcatgacgg tgggcgcggg aggcgctttg aatgttgcgt taaaaagcat 958621 cgtaaaccct ggggaagagg tcattattct tgcaccttat tttgccgaat ataagttgta 958681 tattgagaac tacgggggaa aagccgtcag ctgcccgttg acaagccggt ttgagatcga 958741 cattgaagcg gtaaggcaat cgatcactcc acagacgaaa gggctgattc tcaatacacc 958801 gcataacccc acaggcactg ttctcagcca gaaaaatata gacgatttag gcgctttatt 958861 aaaagaaata gaagagaaga gcggccagac gatttatgtg ctgtttgatg aaccgtacag 958921 tcaattaatc tatgatgaag agctggcaaa tccgtttcaa tcgtaccatc gtgtgatatt 958981 ggccagctca ttcagtaaag atctcggcat agccggagag cggctcgggt atatcggatt 959041 ggacagccga atgccggatg cggacctttt gatcaacgct tttgtgtatt gtaatcgaac 959101 gcttggattt gtgaatgccc ctgtcatgat gcagcgggct gtggcacgaa tggatgattt 959161 aagagtagac gcgagcgctt ataaagagcg ccgggattta atggtagaca ttttaaaaga 959221 agccggtttt gaatttgaaa tgccaaaggg aggtttcttt gtttttccga aatcgccgat 959281 tgaagatgaa gttgcatttt gcgtgcatgc cgcccaaaaa tacaaattat taattgtgcc 959341 gagcagcggt tttggaatga gcgggcattt ccgattatcc ttcagtgtgc cgatcgagca 959401 gattaaaaac tcacgggaca ttttcatttc tttatataaa gattttgctt aagaaggcaa 959461 agaaaagaaa acagttttca aggctgtttt ctttttatat ccgcaaaatc cttcctcttc 959521 caatccagac aggcgcagaa ttgacaagca ggcatgcagt taaggctttc ttcatgataa 959581 aagtctaaaa attaaaaatc atttttggaa tgagttgtgt tacaataaaa tatacaattt 959641 ataatcaaac tttgactttt ggaggtggta tgatggggcc ctctgcttag gcaacaatac 959701 accgcgtacc tcaatgttaa ggaaaaatga ttatatcagg aggtgactcc ttatcctttg 959761 ttgagaggat agggttaaat ggacgatatt gacagtctga ttttaattgg cgtgctcatt 959821 gctttaaccg cgtttttcgt tgcaagcgag tttgcgattg ttagagtgag gagatccaga 959881 atagatcagc ttatcacaga aggaaacaaa cgggcgatac tcgcaaggcg tgtcattaca 959941 gatttggatg aatatttatc cgcatcccag ctaggcatta cattgacatc aatcgggctt 960001 ggcgtactgg gtgagccggc ctttgaacgg ctgctgcatc cactgtttga accgctcggc 960061 ttgccggact cggtttcaca tgcagtctct tttgcagtcg cgtacggctt gatcacgttc 960121 ctgcacgttg ttgtaggtga actggccccg aaaacggtcg cgattcaaaa ggcagaacag 960181 ctgactttac tgatagcggg ccctttgcgt ttattctatt tgctcctgtt tccgtttatt 960241 tggatcctca atggatcggc gcggctttta tgcgggatgt tcggtttgaa gcctgcgtca 960301 gaacatgatg gttcccattc tgaggaagaa ctcaggatgc tgttatctga gagtttaaaa 960361 aacggagaga ttaatccgtc tgaatataaa tatgtgaata agatttttga atttgataat 960421 cggatcgcca aagaaattat gataccgcgg aaggaaatgg ctgctgtgtc aactgagatg 960481 acgatggccg agatgcttga agtcatgctg aaggaaaaat acacgcgctg gccagtcaca 960541 gatggagaca aagacagtgt gctcggtttg gtcaatacga agcatttgtt ttctgatttg 960601 ctgtttatga cagaagaaga acgaatgaag atgacgatcc atccgtatgt gaggccggtc 960661 atcgaagtga ttgaaacgat cccggttcat gacttgctga ttaaaatgca gcgcgagcgc 960721 attcatatgg ctatattgtc ggatgaatac ggaggaacct cgggacttgt gacgacagag 960781 gatattcttg aggaaattgt cggagagatc cgagatgaat ttgatgaaga tgaacagccg 960841 ctgatccaaa agcttggcga cggccattat gtgatggatg gaaaggttcg gatcgatcag 960901 gtgaacagcc ttcttggcgc atcgattcaa gaagacgtcg atacgatcgg cgggctgata 960961 ttaaaagaaa acatcgatat tgaggctggt gaatccattc gcatcggttc atatacgata 961021 aaggtgctga agatggacgg ccgattaatc aagcaaatcg atataaaaga agaagccggc 961081 aacacaaccg ggattacggc gcaccacaag ctgccgctgc ccgagcctgt gatgctgaac 961141 agtgcaacct tgagcgagaa ataagctcaa ggttttttta tattgtgatt gtccagccgc 961201 accaaaatgc aaaaagcgac ccgcaaagtg tcaggacgat gtacaagatg ctttctttta 961261 cacgtttggc cataaggagt tgaatagttt caacgctgaa tgtggaaaag gtcgtaaagg 961321 cgccaaaaaa ccccgtgcca atgataagcg agaccgaagc atttgcaacg tgaagtcctg 961381 taaatattcc gagcccgaga gctccgagaa tattgactgt cagtatgcca atgggcaggc 961441 tgagaccttt ggttttggcg gttatgacat tgccaagcca gaagcgaagc attgcgccaa 961501 gtccgccccc tatgaaaata cccgctagtg tcatttttcc tgcagcccct ttctttgctg 961561 aatgcctgct atgcgccgtc ccacaaaaac accaatcagt gcaaatatga tccctgatat 961621 caatgaggct gccacatata aaagagccaa tgagggttgt ccttgcaaaa gcatcactgt 961681 ttccttagaa aacgtggaca ttgttgtgaa gcctccgcaa aagccggtgc ctaaaaaagc 961741 cgacagcaga ggccgttttg ccccgatcat aaaaaatccg gtcaaaatgc ctaatagaag 961801 gctgcctgcc gcattttcca gccaggttgc cgccgggaac tgaccggtgt gtatccataa 961861 gtttaatccg tatcggaggc aggcgccaag cgcgcctccg ataaaaaccg cgctatatat 961921 tttcatgttt gccatccttt atgatgaaat ccgggtaatc tgtaacgatg ccgtccacgc 961981 ccatggcttg taattttgcc gctgtctttt gattgttgac agtccatgca aatatgttta 962041 agccattttt attgatggag ccgatcatca gacggttaag ccgtgtgtgt tttatattga 962101 catagtttgc aaaagagcgg aaggccttca tctgatttct ggacagcatg ccaaagttgg 962161 gccttgtaat gaccgctgtc ggaatcgaag gataaagctc gcggaacctt tggacggagc 962221 ggaactgaaa ggattgaaca atattattga tagaaaaaga aaattgccct aatagctgtc 962281 ccacctcttc ttcaattccg acttgagacg gatggccttt tagttcaatt aaaaggccga 962341 tttttttgtg gtagcgcttg agcaccgctt ccagggttgg aatacgctct ccttgaaaag 962401 cgggaccgta ccagcttcct gcatcgagtt tttgcaattc ctccaaggta aaatccttaa 962461 caaagcccga tccgtttgtt gttcggtcaa ccctgtcatc gtgtatcaca acaatctgcc 962521 tgtcttttgt aagctggaca tccagttcga tcatatctgc attcattttc accgcaaggt 962581 caaatgcggc aatcgtattt tccggagcgt agccggatgc tccgcgatgg gcaatgatgt 962641 acaagctaag tcagctcctc gtatgggcat ttctgttatt gtatcaaatc catatatgca 962701 ccgcgataca aactggtgaa ttttttctgc catatcggaa tggtccgggc tgaggaatgc 962761 gtataactaa aaaaagacac tcagcgtatc agaacacatt tcgtcagaaa attaggtctt 962821 tcgacatgtt cacaacaaaa tatgatcctt tataatagca aaaaaggagg cgagatcatg 962881 ggaaaaggga gaatcagagt ggaggaaaga attaaagccg aaacggatgc tgaaatgcaa 962941 aaagcaactc tccttgatca gacacaaacg aaaaaaggta agtgactgtc cctattgaat 963001 ctggctgata gatgaattga gaaatgaccc cggcgtttcg ccggggtttt gtgctgcata 963061 agacatttaa atgaacatcc ttacgaatat tttagtataa taaacaattg attgggatag 963121 aggggagaca gtcatgccgg attatctgca gcagtatttt acgcttgata acatcataca 963181 aatcggcatc agcttggcga ttttgctggt gtttcttata cttagaaaat tattcacaag 963241 atattttttt aacctgcttt ttaatttgac aaaccggccg aaaacagaaa tttttaaaca 963301 ggtggttctg gcgtttgata agccggccag atggtttttt gttgcccttg ggctgttttt 963361 agcgatccgg tattcaccgt ttttagatga gcaaatgccg gtcatcagca aaatataccg 963421 ctcactgatt gtggcgctct tgtgttgggg tctttgtaat ttgaccgcaa catcgtcgtt 963481 tatcttccat aaggtgaacc agcgcttcga gcttgacatg gatgacattc tggccccgtt 963541 tttatccaaa ttgctccgtt ttgtgatcat tgcgctcagt gtcagtgtga tcgctcagga 963601 attcaattat gatgtcaacg gatttgtagc gggccttggt cttggcggac tggcttttgc 963661 gcttgccgcg aaggatacca tcagcaactt cttcggcggt attatcatta ttactgaaaa 963721 gccgtttaca attggtgact gggtggagac gtcgacagta acaggatcag tcgaggatat 963781 tacctttagg agcacgagat tcagaacagc acagggggcg cttgtaacgg tgccgaactc 963841 tacgctgtcg atggaagcga tcacgaactg gacaagaatg accaaacgcc agattacgtt 963901 ttccatccat gtgtcctacg ctacgccgat tgagaacctt gaacgctcca ttcattctct 963961 cagaacaatg ctcttagagc atgagggcgt tgataatgaa ataatcatgg tcaactttga 964021 tacgtttgcc gacagctact acaatttatt ttttaacttc tatacaaaaa cgacggtttg 964081 ggctgaaaac cttaatatta gagaggatat caactataaa attattgaga ttttaggtgc 964141 agaaggcgtt cagtttgcat atcccggcca aatggttgtt gtcaagcaaa agcacgaaag 964201 cgaccaattc caggtgaatc taaataaaga ggaaaaggaa cgggcttaaa agagagactt 964261 cgtctgacag aggcggagtc tttttcatgg taaaataaga gaaaaaggcg gtgttgagtt 964321 ggaaacattc aaaagtattc tacatgaagc acagagaatt gttgtgctga ccggagcggg 964381 aatgagcaca gaatcaggga tccccgactt tcgttcagca gggggcattt ggacggagga 964441 tgcctcaaga atggaagcga tgagccttga ttatttttta agttatccgc gtctgttttg 964501 gcccaaattc aaagaattgt tccagatgaa aatgagcggc agctttgaac cgaatgaagg 964561 ccatttgctt ttagctgagc tggagaagca agggaagcag gtcgatattt tcacgcaaaa 964621 cattgacggt cttcataaaa aagcggggag caggcatgtg tacgaactgc atggttctat 964681 ccagacagca gcttgtccgg catgcggcgc ccgatatgat cttccccatt tgctggagcg 964741 ggaggtgccg gagtgcacgg cggccggaaa caatggggac atttgcggaa cggtattaaa 964801 aaccgatgtt gttctctttg gcgatgccgt catgcacttt gacacccttt atgaaaagct 964861 ggatcaagca gatcttttat tggttatcgg cacgtctctc gaagtggctc cggctagatt 964921 tgtgcctgag gatgcaagcc tgattcccgg catgaagaaa gtcatcataa accttgaacc 964981 aacgtattgc gacagcttgt ttgacatggt catccatcaa aaaatcggcg agtttgcccg 965041 aagtttgggc atgaaaaagt gagccgcttt atgcgcctca cttttttatt catgaacagg 965101 aaccattgtg tcctctaaca ctccgaagga atagcctttt tcttttaatt tattgattag 965161 taccggcagc gcatttacag tagcaggaag atcatgcatg agaattacat ttgggcggct 965221 tgaagagctg tgttccatat tctcaagctg ctgtaatacg gcggtcacat actgtgaatt 965281 ccggtatttc cagtccatgc tgtcgatcgt ccaatcccag tacacaaacc catctttctc 965341 cagattgcga atttgtgagg cggttagtga cggcttgctt ccgtatggcg ttctgacaag 965401 atcggtttta tatcctgtaa tgtcctgcag cgtgtcacgc gcctcctgca tttcttttag 965461 cggagatgtc ggtgtttgat agaacaatct gttattgtgg gtaacgccat gtaaaccgag 965521 tgcgtggcct tccttttctg ctcttttcac agcctgcttg aattcgttca tccgcggtga 965581 cagcataaaa aacgtcgctt ttacatcagc gcttttcagt acgtcgagca agcgggttgt 965641 aacggctgaa gggccgtcgt cgaaggttaa gtaaaccgtt ttatctccca tgttctgctt 965701 tgtctgcaga tgttttatca ggagatcggg ggagtcgttt ttcagcttaa ggctttcctt 965761 ctcatctcga agctggccgt ttgttgtgac agtgacttcc tttgctttcg ttgaactgtt 965821 ggaataaccc aaaatcacca taagcaaaag cagcacacat aaaactgcta aacttgcaaa 965881 tttaaaagca agcgaaactg cagaaggaga agcctctcct ctcgtttgtc gcataacaat 965941 ctctccattg gcataaaatc tctacataat gctgtacagc aggcagctta tgaagatgcc 966001 ttatgtttac aacctatgta ttaccagtca agtatacagg aataaaactg gaaagcacat 966061 agaaaatttg tcgaaatgtc agattttaag gaaaaaataa actcctttcc gctatagatc 966121 tcttgatctt tctgtttttc agcttgtcca atatggtaga attagtgata atgacagctt 966181 gaatgacatc agggacatct cgaaaaggga gggcttttat gaaggtttta gtcaatggcc 966241 ggctgattgg gcgcagtgaa gcatcaatcg atttggaaga tcgcggttat cagtttggtg 966301 acggcatcta tgaagtgatc agggtgtaca aaggagtatt gttcggctta cgtgagcatg 966361 cagagcgttt tttcagaagt gctgctgaaa tcggaatttc actgccattc agtatagaag 966421 atctcgagtg ggacctgcaa aagcttgtac aggaaaatgc ggtcagtgag ggagcggtat 966481 acattcagac aacaagaggt gtggccccgc gaaaacacca gtatgaagcc ggcctcgagc 966541 cgcagactac tgcctatacg tttacggtga aaaaaccgga gcaagagcag gcatacggag 966601 tggcggccat tacagatgag gatcttcgct ggttaagatg tgatatcaaa agtctgaatt 966661 tactgtataa tgtcatgacg aagcaaaggg cctatgaagc cggagcattt gaagccattt 966721 tacttaggga cggcgttgtt acggagggta catcctctaa cgtttatgcc gttatcaacg 966781 gcacagtgcg aacacatccg gctaatcggc tcattctcaa tggaattaca cggatgaata 966841 ttttaggact gattgagaag aatgggatca aactggatga gactcctgtc agtgaagaag 966901 agttgaaaca ggcggaagag atctttattt cgtcaacgac ggcagaaatt attccggtcg 966961 tgacgctcga tggacaatcg atcggaagcg ggaaacccgg accggtgacc aaacagcttc 967021 aggctgcttt tcaagaaagc attcaacagg ctgctagcat ttcataaatg aacgaagaaa 967081 agagcccgct ttttacagcg gggctctttt tattttttaa caaatccaat caaaatggag 967141 atcattggcg atatatagag gaagaacgta aatgggatgt agtctatgac tggaacacca 967201 agtgcgctcg ccataaatgc gccgctgacg ccccaaggaa tcaatgggtt aattaatgtt 967261 ccgccgtcct ctaatgatct tgtcagaaat tttcgctgga tgtttcgttt gtcatataaa 967321 gatttaaatg attgtcccgg tattaatatc gataaatact gttcgcccgt tgccaagttg 967381 acgccgatgc ttgagcagac agttgctgca acaagacggc cttttgagcg gatgcctttc 967441 atgacgcctt ccaatagtgc agaaatcaat ccgattttct ccatcaatcc gccgagtgca 967501 aaagcaatca taatgagaga gacagagccc atcatggatt gcagtccgcc tctgttaata 967561 attttagcgg ctgcctcatt gtcagtttcg aaagttgtgc cattttgtaa agctgtcata 967621 aacgcctgca ggctgctgta gggtacaaaa atagcagtca aaattcccga ggaaataatt 967681 ccggcagtca gaacggggat tactgatacc cgtttcattg ccagcaaaac gactaagagc 967741 ggagaaagaa gggcccacgg tgtcacgttt gcagcatctt ttattccggt tatgacctgc 967801 tgaatattat cggttgaagc agcgtccgct gacactgatg aaccgagaaa gtaaaacaga 967861 acgacagtga tgagcaaagc tggaatggtt gtgcccatca tatggcgaat gtgttcaaag 967921 attggtattt cgcctattcc ggctgcaaag ttggttgtgt ccgacatcgg cgacatttta 967981 tccccaaaac aagcgccgca tatgactgcg cctgctgtcc attcaagcgg aacgccagcc 968041 gcgctcgcca cgccgatcag cgctactccg attgtgctta cagttgtcag acttgagcca 968101 acaagtgtgc tgatgatcat acatgaaaac aaagcagtca acagaaggtg gcttggttca 968161 ataaaggata gggcataaac tgtcatagtc ggtattgcgc cgctgtacat ccaggcgccg 968221 attaagatgc cgatcagcgc tagaacaata atcggctgta cgccgttttt gatcccgtct 968281 acaatccctt tttcaatgct cttccaggga aatccaaacc ataaagctgc tgctgaaagc 968341 atgacaacac ttaaaaacag cgggatatga ggttctacat gaagcaagaa taagcaagaa 968401 ataataatgc acaacatgaa tataaataaa ccgacggcta acggaaacgt cagctttttt 968461 tgagaatcca aaataacacc ccatatttat ctttaatgct tttgtgcttt tgggcacgaa 968521 agcattataa cagaaaaaaa cgaaaatcta tgttttttca caattatgaa tataaaagaa 968581 gtgagcacag ggcgtgctca ctttacaatc aggacgggta tatccgattt cgctgaaagc 968641 ttttcactta cacttccgaa tattagcttt ttcagcctgt tttggtctct gcttccggtt 968701 acgatcatat cggcagaaat gcggtttgca tgctcgataa ttgattcagc cggatcgcct 968761 tctaatatat cgatatctcc atctgcctgc tgttcattca gcatcattct ggcttcggcg 968821 atgacttctt ccgtacggtc ttcatagatc attggctcag gtgatgttac atccgatatc 968881 agcggatcag gaacacttgt catgcctccg ctgatatagc ttgcctcagc tgcgggtctg 968941 ggcgggtcga tgacggtctg attgtctttc atatcatgtg aatgggcgac ggtaatagcg 969001 gcatttacgg ttttagcaag atcaatggct gtcagaagcg ctttcttact attttcactt 969061 ccgtcaaacg caacaatgat acggtcagca tggaacatcc ttctcaccct ttcaaagcgt 969121 cttacaacac tactacccga atttgagcac aattaacctt ttcctattca agtaatgatt 969181 gacaataaaa ggttttgttt atatgatgat aaaaagatga aatcagaatg gaaggagggt 969241 ttgctatgcc aaggaatttg cgtgtttatc aaacagtttc atattggcgc ggcaaacctt 969301 ttgttctgtt ttcgtgaacg gttttttagg tcggaccgcg cgctgaaaag cgctgtgcgt 969361 aacatatcgg ttaaaaaagg catggagctg acgcttcatg ccttttttat atacaaaatc 969421 taaggaaaga caggtgtatg ggatgtgaag acaaatacag aggcgagggc agttcgtgcc 969481 aaactggatg aaaaaagctg caaggaaaaa atagaaggcg gctgatgagg agatggggat 969541 agatgttttc agttttgaaa aagcttggct ggttttttaa ggcgtactgg ctgcgctata 969601 cgattgcgat tgtcctttta ttagcagtca atgtcattga aatgtttccg cctaagctct 969661 tggggaacgc catagatgat atgaaagcag gggcatttac tgcggaaggg ctgctgtttt 969721 atatcggtat cttttttgtg ctgacggcgg ccgtgtatat catgtcttat ttttggatgc 969781 atcagctgtt tggcggagcg aatctgatgg agaaaattct tcgtacgaag ctgatggggc 969841 atttgctgac tatgtcgccg ccgttttatg aaaaaaaccg aacaggcgat ttaatggcac 969901 gagggacaaa tgatcttcag gccgtcagtt taaccacagg gtttggcatc ttgacgttag 969961 ttgattctac gatgtttatg atgacgatct ttttgacaat ggggtttttg atcagctgga 970021 agctgacctt tgccgccatt atcccgcttc cagtcatggc gattgcaatc agtctatatg 970081 gaagtaaaat tcatgagcgg tttactgagg cccaaaacgc gttcggggcg ctgaatgaca 970141 gagtgctgga atctgtttca ggcgtgcggg tgattcgcgc gtatgttcag gaaacaaacg 970201 atgttcgccg gtttaatgaa atgaccgctg atgtttatca gaaaaatatg aaagtggctt 970261 ttattgattc actgtttgag ccgacggtaa aactgcttgt cggcgcaagc tatctgattg 970321 ggctcggcta cggagcgttt cttgtattcc ggaacgagct gacgcttgga gagttagtgt 970381 cctttaacgt ttatctcggc atgatgattt ggccgatgtt tgcaatcggt gaactcatta 970441 atgtgatgca gcgcggcaat gcgtcattag atcgggtaaa tgaaactctt tcttatgaaa 970501 cggatgtgac agatccaaaa cagcccgctg atcttaaaga gcctggagat atcgttttca 970561 gtcatgtcag ctttacatat ccaagctcaa caagtgacaa tcttcaggat atttcattta 970621 cggtgcgaaa agggcagact gtcgggattg caggtaaaac cgggagcgga aaaacgacaa 970681 ttattaagca gcttttgcgc cagtatcctc caggtgaagg gagcattaca ttttcaggtg 970741 taccgattca gcaaatccct cttgaccgtc tccgcggatg gatcggatat gtgcctcagg 970801 atcatttact gttttcacgg actgtaaaag aaaatatttt atacggaaaa caggatgcaa 970861 ctgataaaga ggttcagcaa gccattgccg aagcacattt tgaaaaagat ttgcacatgc 970921 ttccgtccgg tctggagaca atggtcggtg aaaaaggcgt ggcactgtca ggcgggcaga 970981 aacaaagaat ttcgatcgcg agagcactca tggcgaatcc ggaaatcttg attctggatg 971041 attcactttc cgctgtagat gccaaaacag aggctgcaat tatcaagaac atcagagaaa 971101 accgcaaagg aaaaacgaca tttattttga cacaccgatt atccgcggta gagcacgctg 971161 acctgatcct tgtgatggac ggcggcgtca ttgctgagag aggcacgcat caagaactgc 971221 tggccaataa tgggtggtac cgggaacaat atgaaagaca gcagctgttc actgcggaag 971281 aagggggagc aggggcatga aaataggaaa aacgttatgg agatacgcac ttctttatcg 971341 aaaattgctg atcacagccg tccttttgct aactgttgcc gtcggtgcag aactgactgg 971401 gccctttatt ggcaaaaaaa tgatagacga ccatatcctc ggcattgaga aaacatggta 971461 tgaagctgcg gaaaaagata aaaatgccgt tcagtttcac ggcgtctcat atgtcagaga 971521 ggaccgattg caggagcctg tttcaaaagc aaaagaagcg catatttatc aagtgggaat 971581 ggcgttctat tttgttgatc aggctgtcag cttcgacggg aatagaacgg tttctgacgg 971641 gaagctgacg atcacaaacg gagacaagag ccgggcatat gctgccgaaa agctgactaa 971701 gcaggaactt ttccagttct atcagccgga aataaaggga atggtgttac tgatctgcct 971761 gtatgggggc ttgcttgtgt tttcggtatt ctttcaatac ggacagcatt atctgctgca 971821 gatgagcgcc aatcggatta ttcaaaagat gaggcaggac gtgttttcgc acatacagaa 971881 aatgccgatt cgctattttg acaaccttcc ggccggaaaa gtcgttgcgc ggattaccaa 971941 tgatacggag gctattaggg atttatatgt cacagtgctt tcaacatttg tgacaagcgg 972001 aatctatatg ttcgggatat tcacggcttt gtttctgctt gatgtgaagc ttgcgtttgt 972061 atgtctggca attgtgccga ttatctggct gtggtcggtc atataccgga gatatgcgtc 972121 atattacaac caaaaaatcc gctcgatcaa cagtgacatt aacgcaaaaa tgaatgagtc 972181 aattcaaggc atgaccatta ttcaggcttt ccgccatcaa aaggaaacaa tgagagaatt 972241 tgaggaatta aatgaatcac atttttattt ccaaaacagg atgctgaatt taaactcctt 972301 aatgtcccat aatctggtca atgtcatccg caatcttgcg ttcgtctgtc tgatctggca 972361 ttttggcggt gcgagcctga atgcggcggg gattgtttct atcggtgtgc tgtacgcgtt 972421 tgtcgattat ttgaaccggt tatttcagcc gatcacaggc atcgtcaatc agttttcaaa 972481 gctggagctt gcaagggtct ccgccgggcg tgtttttgaa ctgcttgaag aaaagaatac 972541 ggaagaagcg ggtgaaccgg cgaaggagcg cgcgctgggg cgggttgaat ttcgtgatgt 972601 gtcatttgcg tatcaagaag gtgaagaggt attaaagcat atttccttta ctgcgcaaaa 972661 aggcgaaacc gtagcgctcg tcggccatac cggatcagga aaaagctcga ttttgaatct 972721 tctgtttcgt ttttatgatg cgcaaaaagg tgatgtctta attgatggaa aaagcattta 972781 caacatgtca agacaggaac tcagatccca tatgggtatt gtgcttcagg acccgtactt 972841 attctcgggc acaatcggat ctaacgtaag tctggatgac gaaagaatga ctgaagaaga 972901 aataaaaaat gcactgcggc aagtcggtgc tgagcctctt cttaagaagc ttccgaaggg 972961 cattaatgag cccgtgattg aaaaaggcag cacgctatcc tctggagagc ggcagttaat 973021 ttctttcgct agagctttgg cgtttgatcc cgcgatcttg attttagatg aggcaacggc 973081 gcatattgat acagagacag aggccgtgat ccagaaggcg cttgatgtcg tcaaacaagg 973141 acgcaccacc ttcgtcatcg ctcaccggct ttcaacaatc agaaatgctg atcagatttt 973201 ggttcttgat aaaggagaaa ttgttgagag agggaaccac gaggaactga tggcattaga 973261 aggccaatat tatcaaatgt atgaactgca aaagggacag aaacattcca ttgcataacg 973321 ctcaaaaacc caaaacaatc gtgttttggg tttttggttt atgtagtcaa taagccagtc 973381 cgacacggtt tccgacatac tcacctgtaa cgagctcacg atataaaaag tccgcagtat 973441 cgccgaccga aatgcttgtg ccgccctcag gcaaaacgtt acgctccgta cgataaacgc 973501 cggttgctgt tccgtccggg aggtaagtgg ggcagatgat tgtccagtct aatgatgatt 973561 ctttaagcat ttcgtatact tttgcatgct ccttggctgc gcgggtctgc tttcgtttcg 973621 attcatttgt ttcaaaccgg tattttcccg gttcatatcg ggaatctagg atccctgcgg 973681 tgccgatcgt aataagccgt ttgatatgct gttcctccat aacggagaga atgtgtgcca 973741 tagcagttga caaggtatca tcaccatctg tgcctagaca gctgatcacg atttcagcat 973801 tctccattat ttttttcaca tcttctaagc ggcgggcgtt ccccatgaca gttctgtctt 973861 ttgaaagggg aagatcagca tgttgagatc tgatcagagc gaaaatatca aatctttcat 973921 ctgctgcagc ttgtgttaaa aaggcttgtc cgacgcggcc gctggctcct aataaagcga 973981 ttttcattaa aaaacctcct cgcctttcat tataaaagga tgttctcagt ttgaacagcg 974041 cgggaaagaa tacctgtaca aataaacaga acgatgggaa acatattcat gaatcatgga 974101 tacacttacg aattgaacca gctcccaatt cacaatggtg atgaatgaca ccccgattcc 974161 ctcccttttt ttctaggata tgtggagcag gaaaaaaggg tgacaaaata aagagagcgc 974221 ggaaaccgcg ccctctatag ccatatattg aattgttatt gaactctgcc gcccatttgc 974281 tgctgagcga aagatactaa acgttttgtg atttctcctc cgacagaacc gttagcgcga 974341 gaagttgtgt ccgctccaag gttaacgccg aattcagaag cgatttcaag tttcatttga 974401 tcgatagcct gagctgcgcc aggaactagt aagtcatttg aagagttttg gttagccatg 974461 tgtaaaatct cctttttatt tagtatggtt gggttaactg gagttgcacc aatctgtgaa 974521 cccttctcgg gtgtcactgc cgcctcggcg taacccaatg ctttgccggc ttgttactac 974581 gtattatgtt aaaatggccg gaaaatcatg cggagaattg tgtggtaaat cttgagaaat 974641 aaaaaaagct tagccgttta ggctaagcta gtcataaata tgaaaaagca tcagttcatg 974701 tatctcgttt gtaagagcag gctcgtcagc gcgggcggga aacaagtctc cccattcaat 974761 ctcaccgctc ttatgataga tgccttcata atgggtccct ttataataaa atgaaatttt 974821 ccatccgggc agcttttctt ttgggaacaa aggtttccag ctgaaatgag aaatcattac 974881 ggccacgctc cttacatttg gtatcaattg acctaaataa aaacggctta tgttcattgt 974941 atcattgttt cagaacatca ttgaagaggc ctaaatatgc agtttgtccc agctttggat 975001 aaagataagc ccgctttatt aaaaaagcgg acaggttacg aaggccacaa tgcttccgga 975061 gatgtgattg ccttctcaga taaatatgac gcgtattcaa aacttcttcg ttttgtaaga 975121 gaatcaacat gatgcaaatt tggatgagaa aaaatgcttc ggcccgggcg cgaattcgct 975181 tcaaacatcc atactttacc gttctgatca atgccaaaat cgaaaccaat ctccccgata 975241 aatccctcga tatgatcatg aaggacatgg cttgcagtca gtgccgctgc agaaagcttt 975301 ttaatgacct caactctttc agcgggatca tcgtatactt ccgcaagtgt ctttacagtg 975361 ccgccgttag aaagatgtgt tgtaatgctg ttctttccgg aaatttttac ggcgattgct 975421 gtcactgtcc attttccttt tctgttttta ttggtatgga cacggaaatc cgctggtttg 975481 ccttgaaatt cgatgagatc aacaccttgc tgaatgagaa agtcggacgg gttgtgatgt 975541 ttttgaaatt ctgcaaggaa tgaggcggca tcggaataat caattgatgt aaaagttttg 975601 gcgtcattcg tatgctttac cgtcaggccg ccatctgttc ttgtcagctg ataaatgccg 975661 gtgccgagtg ctccatttgc cggtttgata tagacttttt tgtatgcgcc acagagctca 975721 tctatcagct ccacagacgg tgtcagctcg gatctaggca aaaagggtgc cgttcttgga 975781 tctttttcga gcaattgatg aacgttccat ttattgaaaa acgttttatt aaaccatggg 975841 atctgatatt catcgatcag cctctttttt gtatgttgca agagaagtga atcttcaatt 975901 tttcggttcg gcaaacggtc ataaacgacg ttcggcaatg gaacgatttt tttctcccag 975961 ccgttttccc tgtaaaggag gccttcaatc gtgccttcct cccaattgat ttggtgcgcg 976021 ccaaaaacga agcagtagcc cccggcttgc tcgtgtaacg tgacaagttt agaaaaaaag 976081 agggaacgat ccttaaatgg gcgttcaaga gatacagtaa accctgccgt aaagatgccg 976141 actaacggcc cgatatgcac tgtatgatca tgaatcagta tatctgccct gcttcggtgg 976201 ggaagcaaaa gctcatgaaa cagattttca gagagaagca cggtttgttc cagatgccgt 976261 ctgtaagcaa cgtggcatct gacaaccttc gttccgaatg cggcatgcaa aagtccgtct 976321 tgcttcagcg aagagggcag aaacagggtg ttttcactgg ttttgtctat gccgatcaaa 976381 aaccgtttag gattcacgcg gaagaactcc tttctggctt tgctcagaaa acagatattg 976441 gcagcgtttt aggggacaag tgtacagctg ttctttttgc tcgggagaga cacgcaggat 976501 tgacttcctg cctggtttgg aattgatatc taaaatccaa attctcccgt cctttgcaag 976561 acatatatca agaccgagtt caaacaacgg cccatagcgc tcgtcaagat aatacggaac 976621 cgattgggta attgaaaaca catcatctag taaaaccact tgctgttttt tcggtatatc 976681 ttcaaaccag gagtcaaatg tcagcgcatc agatccgcct gacaaattgg ccagcagccc 976741 gtgtttgtat ccgcgtctta ctgcctttcc gactgtattc cattcacctg cttcgttttt 976801 ttccataaac agacgaatat cacaagggta ttgttcctta tcttgaatgt ttaagtaagg 976861 ctgaagcaaa tattgatgct gaagcacttt tttgcaccat gttttaaaag aagtctggtt 976921 ggaaaacgtt tttgtctgct tatcctttcc gatgtgataa gtagcagtga tgtttttctt 976981 gcccagcttc aaaagaatca cgcctctgcc tcccgcgccg aatgccggtt taaggatgca 977041 ggctttttct ttggataaaa aggagtgaat ttgttcgtag cggctcacct ttatcgtttc 977101 gggaatatag ggattgatta cagagtgctg ctgcaaatcg tgaaggacgg tccacttatc 977161 gggaagaccc cgcccgataa attccgtttt cggatatttt ttgagccact caacgattgg 977221 ttttgctttt tgggaatgtg aatccttgcc gtaaaaacag cgatcataaa tataatctgg 977281 aatcgccatt tcagtttcgt tccatgtgct gctggccgaa tgatagaccg atgctttgac 977341 acgcaaagtg tcaggtgaaa tatcaaatgg tgtaaaccgg atgaaacgta tgccgaattc 977401 gggtgctctt ttggccagtt ctgcggaata atccgcttca tgctggcggg ataaggacat 977461 aaaaccgagt gttatcatgg tgagactccc ccttttattc aaaagctgcc ggcgggtgtc 977521 cgcagcttta cactaaatac atgtaagacg aacgcagctg acggtattct actttacaga 977581 atacgattct ccaccttgcc ctattccaaa agaacaagct gattttctaa gaacaggaat 977641 ttgtctcctc gtttgctaag tgattgcatg agcctctata atacgtatag gtacataatc 977701 tatatgaaaa aagctgaagc acagatggag gaagatgaat aggaatgggt attgcaggaa 977761 cctttatttt tatgatcgtg atcggcgctg ccattggagc ggtgaccaat catttagcaa 977821 ttcaaatgct gtttaggccg tataaagcgt actatttgtt tgggaaacga gttcctttta 977881 cgcccgggct gattccaaga cggcgagatg aacttgcaaa acaaatggga ctgatggtag 977941 tcaatcatct cttaacccct gaaggcatta aaaagcggct cgtctctgat gcagccaaaa 978001 cgcaggctct tcgagtgggg gaacagctga ttcaaaagct gtcactttct gaagtgacag 978061 taaaagaagc gcttgaaaaa gccgggatga agcgccccga aaaagctgct gatgcatgga 978121 tcagcagctg gaccgatgat aagctgcatg agcttttccg ccaatacggg gaccaatcgt 978181 taaaagagct ggtgcctata gaggtgcagg aaaagcttga ggaaaaaatt ccgatgattt 978241 caggatatat attgtcacgg agtgtccgtt attttgaaag tgatgaagga aaaatccgtc 978301 ttggcaatat gattgatgac tttttaaaag agcgcggcat gcttggaagc atggtgcaat 978361 tgtttcttgg caattcaagc cttgcggatc gcgtgctgcc ggagctgctg aaattcttgc 978421 gcaatgagga aacaaataaa ttgctttctg atctcttaaa aaacgaatgg ggcaagctga 978481 gggagtatac gtttaatgaa gcagatgaaa aatggaatgc aaaggcgctc attttcagtt 978541 tgaaacgaag agtgctgcaa gcattttcga ctgccccttt cttcaacaat acgattggca 978601 cgcttaccgt ccgctatgaa tctgagctga cccagcaaat gctgccggca ctattagaca 978661 aattgcttga aggtatttcg tccaaccttg aaagtgtctt aaaacggttg cgtcttgagg 978721 aaatcgtcaa ggagcaggtg gatcagttcc cggtggagcg tcttgaagaa atggtgctgt 978781 ccatttcaaa aaaagaattt aaaatgatta cctatttggg gggccttctc ggcggaatta 978841 taggcgcgat tcaagcattg tttgtcatcc ttttttaaga agaaatggtt tttgattaat 978901 gaaaggagct ccatagtctg ttatagtgga gtggtatgtc aaacggcaat gatgaaagga 978961 gctatttaca atggctgtta atttttatga tgtagcgtat gatctggaaa atgcattacg 979021 cgggagcgaa gaattcaccc gtttaaaaaa cctttacgac gaagttaacg cagatgaatc 979081 agcgaagcgc atgttcgaaa acttccgtga tgtacagctt agactccagc aaaaacaaat 979141 ggcaggagaa gagattacac aagaagaagt gacgcaggct caaaaaacag ttgcgcttgt 979201 acagcagcac gaaaaaattt ctcagctgat ggaagcggag cagcgcatga gcatgctgat 979261 tggtgaattg aacaaaatca ttatgaagcc tttagaagag ctttacggca gtgttgaagg 979321 ctaataagca aaatcccttc ttggataaga agggattttt tattcactca gcaaacttgg 979381 aaatccaatg aatcttttac ctctccattg atgatgactg ataatgtatg aattcctttg 979441 taatgctttc tggtggttaa atccttaaag gattggattc ttgtgtatga cttcgtttcg 979501 ttttttcgta tatttgtttc tgttatttta aatactttct gatgacgctg gcctcttgct 979561 tttacaaaat caattgcgta ctcaattctt actttttgat ccctgtctga atgaatatag 979621 aaagaaaatt caaggctttc gccaataact atacgtttgg gctggcatgt taaatcatgt 979681 agttgtatcg aatcagcatt ttcataacca aaaagcgcta aggcctgttt atcacccttt 979741 tttaataagg tccgataggc gtgtttgata atccagtctg tatggggatg tgttccgtac 979801 cattgatctg cgacttttct cagtaaatga ggatgcgttt ttgatatatc attaaggttg 979861 ttggccacgc tttttcttac atataaagac tcgtcctgca tcagcttctc aaggatcggc 979921 aatacggggg aagggtccga tttcaaagcc ggtatcgatt ttccccatgg caggcggggc 979981 ctgctgcctt cgctcgcaag tcttctcacg tgttcatttt tatgctcaga ccatgcaagc 980041 aattgtgcaa tcatcttttc ttgatctaac agcaaaaaag gccttacagc aaattctgag 980101 gtcgaatatt gcgtaaagga ttccaatgcc tttattgatt cttcccaatg cgctaacccg 980161 tactgttcca cataatctgg aaataaaatt ccgctgagtc ctttaaaatg aggggctgta 980221 tcccgtaaaa ttgtgagcgc ttcaacgtat tgttttggca aagtttcgta taaagaaact 980281 gtcacgcggc gcatccgctc ttttaaagtg agttcaggcc agtcctccag ccgtaatgta 980341 tccaagaatc tgtttttgtt aaaatcagga taggatgacc ttacatgatg gatcaactga 980401 gatatcagtt cttcattata tatttctttt aaatcagcca tataaacacc gctttttcgt 980461 ttattattta tattgtatgg gaatgtacgt tctggatcaa gtgtatagtc ctaaaaatta 980521 acaactgatc ctaccacgga tatacaaaag ttggttactt tttttagtta aaaaaaccct 980581 tgtcatcgga aaggaaaact gagataataa cattgaaagc gcctacactt acctatttca 980641 aatggatacg gtcgcatatc atgccgttat atagagggga taagcaacag agagtaagtg 980701 ttcggagcgc atcattggtc aaacaagggg ttcctgatac atgatttttc gtaaatcgaa 980761 ataacgatat tagggagaat ggctgcttcg atcgtatcct atcaacaagc catacataaa 980821 gtctgctgag ccaggctttt tttgctttaa gaaaaggttg ttctaaacac agagacaggg 980881 tcatatccta tacacaagta cagtcatcaa ggagggggac atctctgtgt caaaacaatt 980941 gcttgcctta aatatagatg gagcgctgct tcggtcgaac gggaagattc atcaggcaac 981001 gaaagacgcg attgaatatg taaagaaaaa agggatttac gtcacacttg tgaccaaccg 981061 tcattttcgc tcagcacaga aaatagcgaa atcgctaaag cttgatgcca agctgatcac 981121 ccatagcggg gcatatatcg ctgagaaaat tgacgccccg ttttttgaaa aaagaatttc 981181 tgatgatcat acctttaaca ttgttcaagt gctggagagc tatcaatgca atattcggct 981241 tcttcacgaa aagtattcca tcggaaacaa gaaaaaggtg aattcgaatt tattagggaa 981301 agcactcatt catccgtctg acccgatctt ttatccagtc cagttcgttg aatcattaag 981361 cgatctcctc atggatgagc cggtgagtgc acccgtcatc gaggtgtaca cggagcacga 981421 cattcagcat gacattacag aaacgattac aaaagccttc cctgcggtgg acgtgattcg 981481 cgtaaacgat gagaaactga atatcgtccc gaagggtgtc tcgaaggaag cgggtttggc 981541 cctcgtcgct tcagagctgg gcctgagtat ggatgatgtc gtggccattg ggcatcagta 981601 tgacgatctg ccgatgatcg aacttgccgg tcttggggta gcgatgggga atgccgttcc 981661 ggaaattaag agaaaggcag attgggttac aaggtccaat gacgagcaag gtgtcgctta 981721 tatgatgaag gaatatttcc gaatgcagca gcgaaaagga tttcttgata agttccacat 981781 gaaacgtgtg taaaaaagcc gctcgcgccc tgacaggtgc ggcggctttt ttgccggatt 981841 gattttagca gtttatttct gtacactaaa gaaagttttg aatctgataa attaggtgat 981901 gaagttgcaa attaaaatag aaggcataca tgatgaccgc ctgcatcggc ctctgcaaaa 981961 tattgcaaat ttgttttatg aagagtgcga gcttgcgtat ggcggagagg agcccgcaga 982021 ttttgtcatt tctttagcgt tgtcacaaac ggatgagcat gtgacggttt ctggagaagt 982081 gaagggtact ggcataaagg aacagcatac aaaattcttt tctccagaca tgactgaaaa 982141 agaagctttt aagcaagtga aaaacacaat ttcttatgtg tatctcaatc ttcttcaggc 982201 gcatacgggc attacgcaga agtggggaat cctcacagga atccggccca caaagctgct 982261 tcataaaaaa ctgcaaagcg gaatgtccaa ggagcaagcg catgctgagt tgaaaaaaga 982321 ctatttaatt catgatgaaa aaatcatgct aatgcaggaa attgttgacc gtcagctggc 982381 ggcagtgccg gatttgtacc gagtaaagga tgaagtcagc atttatatcg gcattccgtt 982441 ctgcccgaca aaatgcgcgt attgcacatt ccctgcgtac gctatccaag gacaggcggg 982501 cagagtcggc tcattcctat ggggactgca ttacgaaatg cagaaaatcg gtgaatggct 982561 gaaggagcat gatgttaagg ttacaaccat ttactttggc ggcgggacgc cgacaagcat 982621 tacagcggag gagatggatc tgctgtatga agaaatggtc cgctccttcc cggatgtgaa 982681 aaacattcgt gagattacgg tggaggccgg tcgtcctgac acgattacag aagaaaaact 982741 cgccgtttta aacaaatatg acattgatcg gatcagcatc aatccgcaat cctacgaaaa 982801 cgaaacgcta aaggcgatcg ggcggcacca tacggttgaa gagaccattg agaaatatca 982861 tctgtcacgc cagcacggca tgaataatat taacatggac ttgattattg gtttgcctgg 982921 ggaaggcgtg aaggagttca ggcacagtct ttcagaaaca gaaaaactga tgccggaatc 982981 ccttaccgtt catactcttt catttaaacg ggcgtcagaa atgacgagaa acaagcataa 983041 gtacaaagtt gccggcaggg aagaggtttc tcaaatgatg gaagacgcgg tagcctggac 983101 gaaagagcat gggtacgtgc cttattattt ataccgccag aaaaacattc ttggaaacct 983161 tgaaaacgtc ggatactctt tgccgggaca agaaagcatc tacaacatta tgattatgga 983221 agaggtgcag acgattattg gcatcggctg cggcgctgct agtaaattta ttgatcggga 983281 tacagggaaa attacgcatt ttgcgaatcc gaaagatccg aaatcgtaca atgagcgctt 983341 cgagcactac acggacgaaa aaatcaaata tttagagcag atttttgaaa aaacgacaaa 983401 gcagcactga ttacagtgct gcttttttta tccctgtttt tttgcgggct gaacctcagg 983461 cttccattta aataccttgt tcagcaagcg gtaaattcgt tttgattcct ttgtgacaag 983521 cggtcccaaa atcgccagaa tgaggacata taatgcggca aacggcttta atgtggccga 983581 cagtccgccg gctatcccga gattcgcaac gataatcgaa aattctcccc gcgatacgat 983641 cgtcagcccg atattcgatg aagccttatg agaaagccct gcgcgtcgtc ctgccaccat 983701 tccggcgata aaatttccca gaatggtcaa aatcactgca cccaacgcaa gccaaaccgc 983761 ttcaccaagc gaaaacggat cgatgctgag gccgaagctg aaaaagaaca tcgcaccgaa 983821 gaagtcgcga aacggaacaa cgaggtgttc aatcctatcg gaatgctctg tttctgaaaa 983881 gaccaaaccg agcagcagcg cgccgattgc ttctgctaca tgaatcgtct ctgaaaaacc 983941 ggcgataaaa aagagtgctg cgaaaatgac gataataaac acttcgtttg agcgaatgtc 984001 caacagtttg ttcaacagcg gcgggagttt tcttgctgcg ataaaaaaca gcagcatata 984061 accgaaggcg atcaaaatgg acaagagtgc actccctacg gatgtcgcat cacctagtat 984121 aaggccggaa acaacggaca gatatacggc aaggaaaata tcttcaaaca tgatgatgcc 984181 gagaatcaat tcggtttccg ggttggcggt tctttttaaa tcaacgagca cttttgcgac 984241 aatcgcactt gacgagattg tgatgacgcc tgcgaggatg aggacttcca gaaaggaaaa 984301 tccggtgata aacccgtaaa gcagtccgag gctgaagtta atcaaaatat aaatcgtccc 984361 gccgaccgcg attgattttc ctgatttgat taacttcccg acagagaatt cgagtccgag 984421 atagaagagg aggaacagta cgcccattcg cccgaaaaac tcgatgattt cactgctttg 984481 aataaatgtt agatcaataa tccccatttt cggcgcgtgc ggtccaacaa gcattcccag 984541 cacaatcaga aacggaataa tcgaaaattt aattttattg gcgatcacac tggcgattgc 984601 cacaagcaca agtgcagttc cgacttcaaa tacaagatgg tccatcgggg ctcacacgcc 984661 ctctccagaa agaaaatcgt gaatcagttt cttcagatgc tttctctcac ctgagaggac 984721 aagggtgtca ttttcttcaa taatcgaatc cgctccggga tttaggagct tttcctggtt 984781 gtgtttgata atcgcaataa cagtgacatc gtaattctgg cgaacatcaa gctcaccgag 984841 tgtgcgtccg atcgatttgg cgcctttttc gaccttaaac cattcaataa taagatcgct 984901 gaaggccatt tcgatggact ccagagcttg cggtttatag accatgcccc cgagaatagc 984961 tgcaatttgc cttgcttcag aatcatccaa tgaaatattt gaaagaagct catccgggtc 985021 ccggtcatta aaccggtaaa tttcccttct tccgtcatca tgaatgataa tcgtcatttt 985081 ttcgtggctt cttgtttcga tttcaaactt tttgccgatg cccggcagat cgttttcttt 985141 aatattcaat gaaaatccct ccgaatgtag tgttggcagt atggggtgag ttacaaataa 985201 aacttgagca aattatattc ggaggtaatt agactggtat ttgacaggga cggccaaagc 985261 cttttccagc ctgtttatca gcggttcgtc aagtggtttg acagagagct gcctgacaga 985321 ctgcgccagc gggctgtact ctttgatcag ctcagccggg tgcatgctgc ccggcgatgg 985381 cgtttttgcc gattgtgttt cctgcggata tgaagacata ggcacatagc tgtcagtgct 985441 tgcttcaaac tgggaaggca gaaccacgtc cgaaggggga aagtacacca taaataaact 985501 taacagaaaa ctgatcagca atttatccat gttcctttcc tcccttctca tcaagatatc 985561 ccttcttttt cactatataa aactttatgt ttccattcaa acaatatgca tttttcagta 985621 tctattgacc ttgaaaaata aaaaggttta tttggggatg gcggggaatg tataggagaa 985681 agaaaaaagt aagcgcatac atggaggtgc ttttaatgga gtttgttcaa tatgcatgta 985741 atggggccgt tgcagagatt atcctgaatc ggcctgatgc ccatcacgcc ctgaatgaac 985801 agatgctgtc tgaattgaag gaggcagtcg aaatggcggc tgcaagcgag gcgctcatcg 985861 ttctcctgag aggaagcggg aaaggctttt cggccggcgg tgatatcagg atgatgacgt 985921 cagagcatga ccctgaccaa tttaaacggc tgatggatac gattgaggct gtcaccctga 985981 atttatatca gatgaagaaa gtgacaattg cagccattca tggtgctgct gcgggactgg 986041 gcctgagttt ggcgctttgt gcggacattg tgctcgctga aaaaaacgcc gttctcgcga 986101 tgaattttat cggcattggg cttgttccgg acggcggagg acattatttg ctgaagaaaa 986161 gaatcggtga agcaaaagcg aaaaaactga tttggagcgg aaaaaaacta tctgcctcgg 986221 aagctgccga tatggggctt cttgatggga catttgccgg agaccctgcc gaaggcgcaa 986281 gacccattat cgaaaccctg ttggcctccc ctcttttggc gatgatcgaa acgaaaggta 986341 tttttcaaag cctccaaatt gaagaactga aaaaagtgct atcccttgag cgcagcgccc 986401 aagagagaat gagaaggacc aaggatcacc aagaaggaat ccgtgccttt ttagaaaaac 986461 gggagccgaa gtttcaagcg taacagatca gccggaaagc tgatcatctg tgaaacaaaa 986521 tcagctttcc ggctgcattg actaaacgat gagtatgact atgaagctct ttttctttta 986581 agagggcttc accatgcgtt tttgccgctt cttcatgttc tgcctcgaat tgctcgttta 986641 ccagcgtgtt ccccgaagga tcaaatacgg taaggaaata atcagccatc aggtttctcc 986701 tccattttaa ggtttatcag tctttcttca tttatattct aaaaaggaaa tcaaaatcct 986761 ttattatgct ttatccaaaa ttagtatata atgggtcagg gaaggaggag attcagtgct 986821 tacaattgat cacgtaacga agacatttgg agattataaa gccgttgacg gattggactt 986881 agatattccg gaacagcaaa tgttcggtct attaggcgca aacggagcgg gaaaaacaac 986941 aacgtttcgc atgatcctag gattattaag cattacggag ggctcaatca gctggaaggg 987001 ccgtcctgtg aattatcata tcagcaacaa aatcggttat ttgccggaag agcggggcct 987061 ttatccgaaa atgaaggtaa gggatcagct cgtctatctt gccagattaa aagggatgga 987121 gaagcgagag gctgtaaaag agctcgggac atggcttgaa cgcttcaata ttacagatta 987181 cgagaataag aaggtggaag agctttcgaa ggggaatcag cagaaaatcc aattcatttc 987241 ggcagttttg cataagccgg agctcctgat tcttgatgaa ccattcagcg gcttggaccc 987301 tgtcaatgtt gagctgctaa aagaggccgt gatctcgctg aaaaacagcg gtgtttctat 987361 tttattttca agccatcgga tggaacatgt ggaggagctt tgtgagaacc tttgcatatt 987421 gcagaaagga aaaccggttg tacaaggcaa gctgaaggag atcaagcgtt ctttcggtaa 987481 aaagaatgtt accattcact ccgatgacga tctgcgcttt ttgcagtccc atgaaggcat 987541 tcttcaatgg aaggaaacgg cagacggcgt caagctgcag attgccaatg aagacatttc 987601 tcaagagatt tttgcgatgc tccaaggaaa agggtttatc agaaagtttg agcttgaaga 987661 gccgtcactg catgatattt ttatagaaaa ggtgggggcc gtctatgaat aaattttgga 987721 tcatgctttc tcatacatac aaaaataaga ttatggcaaa atcctttatt atttcgactg 987781 tcatcacggt gctgcttgtt ttagttgtaa cgaatctgga gtcgatcatt tctttgtttc 987841 aaggtgacga tgcgaaagaa aaaatcgccg ttgttgatga aacaaacgaa ttatatccgg 987901 ttttttctaa gcagctgaaa gcggtggata cagacggcga tcttgatgtg aagctgtcga 987961 agcaatcgga ggatgaggtc acaaagcaag tcaaagatga atcactcgat ggcatgctca 988021 tcatcaaacg agatgaaaaa gggaccattt caggaacata taaagcgtta acgatttctg 988081 atgaaagcac gtatcaaaca ctgcagcagg cgctgacgca aaccaaaaca gctgtcggaa 988141 cagcggagct cggcgtgtcg caggaaacga ttagcagcct ttatgcgcct gttactgtgg 988201 ggcagaaggc gctgaaagaa ggggcaaagt ctgaggaaga gcttggccag acggtagggc 988261 ttgtttacat tatgctgttc gtcatttatt tctcggtgat tatgtatgcc agcatgatag 988321 cgatggaggt cgcaaccgaa aaatcttcgc gagttatgga aatcctgatc tcaagtatgc 988381 cgccgatcca gcaaatgttt gcaaagctgc ttggtatcgg gcttgtcggg atcacacagc 988441 ttgctattat tataggagcc ggctctctgt cgcttaagct gaaccaaaag agcgaaacgg 988501 cttcatctgt cggcggattc cttaatttga ccgacgtatc tgcaaccact gtcatctatg 988561 ctgtcatttt ctttttgctc ggatactttt tgtacgcgac acttgccgcg tttctcggca 988621 gtgtcgtcag cagaatagag gacgtgcagc aaacgatcac gccgatgacg cttttggttg 988681 tcgccggttt tatgatcgcg atgttcggtt tgaatgcgcc tgacgcagga tttattacgg 988741 taacttcgtt tattccgttc tttacgccaa tgattatgtt cctgcgcgtc ggcatgcttg 988801 atattccgtt ctggcaggcg gctgtcggaa tcggaatcac actgctcacc attgtcatac 988861 tggccgttat cggcgccaga atttataaag gcggtgtatt aatttacggc aattcaagcg 988921 cgttcaaagc gatcaaacaa gcgctacgtt tagcgaaaaa ctgattggaa aacagcctgg 988981 ggattctcag gctgtttctt tattgacaga acgtgcattc gcaagaattc ggtgctaaaa 989041 taagggtact tcatcctgga aaggagcaga atgttgactg atctaacctt tattcatgcg 989101 gcagatcttc atcttgacag cccgttttac gggatatcgc atctgccgga gccgattttt 989161 gcccggatta aagaaagcac gtttgcaagc gtgagacata tgatagacgc cgcagtgaga 989221 gagcacgttg atttcatttt gcttgcggga gatctgtttg atgaagccaa tcgaagctta 989281 aaggctcagc tctttttgaa aaaacagttt gaaagactca gagagtgcgg aatttcggta 989341 tacgtcatct ttgggaatca cgatcatctt ggcggggagt ggacgccgat tgaatggcct 989401 gagaatgtcc atattttttc gtccgctgtt ccagaagaaa aatcgttttt taaagaaggc 989461 aggcgcatag caagcattta cggcttcagc tatcaagcca gagcattgat ggaaaaccaa 989521 gccgcccgct atcggagatc aactgacgca ccgtttcata tcggcatgct ccacggcacg 989581 ctgtcaggat ctgaaggaca cgatccgtat tgcccgttta cacatgacga cctcgtgaaa 989641 agcgggatgg attattgggc gcttggccat atacataaac gccaggttct atctgccgag 989701 catccggcag tcatttaccc gggaaacacg caagcacgcc atataaagga gacgggagat 989761 aaaggctatt atctcgttca tgtgacaaac ggagatatat cttatgaatt tcagagagcg 989821 catgatgtcc tgtgggaaaa agcggcggtt gatgtgacgg aggcaaagaa tatgacagcc 989881 ctcttccaaa tggtggagga cacgttttcg aagctgcgga aaaaggggag ccctgtttgt 989941 gtaaggcttg ttttacaagg gacggcgccg gaatggctgc tggaggcgcc aaaaggcacc 990001 ttggatgagt ttcttgaagc tcttcaggaa caagaagcgg aagaggaacg tttcgtttgg 990061 cctcttagat tggacgatga gacagaaaac gaagcaaacc taacaaacct tgatcctttt 990121 tttggcggtt tatttgaaga cattgatcgc agcgatctgt cagacgtgct ggaagggctt 990181 gagcggcatc cagtgtatag aaggcacgcg gaccggttta gccaagagga ggtaaaggaa 990241 ataaaagagc aggcacagat aatattgaaa agacagctta aggtgcttga tacatgaggc 990301 ggtgacagct ttgcgaatta tatctttaca tatctaccaa tacggaaaat tttccaatcg 990361 gacctttgac ttttccgcct ctcctgtcca agtcatctac ggattaaatg aggcaggaaa 990421 aacgacgatg atgtcattca ttgaaagcat gctgttcggt tttccgaaaa cgaaaaagta 990481 tgaaccgaaa acaggcggtg tctacggcgg tgttcttgaa gctgaacatc ctgagtatgg 990541 ggtgctgaag atcgaacgga cgaaagggac tgccgaaaaa ctaagcgtgt acacagaaaa 990601 gggcgaagta aagcagggag atgttttaaa gcagctgttc cagggcacag acaggtcgtt 990661 gtacaaagcc atatattcgt tcgacgtatt cgggctgcag gaaattcacg cctttaatcg 990721 ggacaagata ggggaatttt tgctcttttc cagcttgttt ggtgctgaag ccgtatcaaa 990781 gcttgattca aggctgacga aggaaagcga aaggctctat aaaccaaatg ggcgaaaccc 990841 tcaattgaat caggagctgg aaacgcttaa gcagctggca gttaagctaa aacaggctga 990901 agcagaggaa gcgggctatc atcagcttct cgaggaaaaa cgaacgcttg aagcccgcct 990961 tgcagccgcg gaaaccgaat tgaaagagac ggcgggacat atccgaatga ttgagggagc 991021 gattgagcga aagccgctgc taaatgaaaa agcgacactc gaacaggtga ttgcagaatt 991081 tccggaacac gcaggacaat ttcctgctga cggactgcat cagctggaaa aatatgaatc 991141 ccatcttcac ccgaaatcag cacagcttga ggcgcttcgg gtgaagatgg cggagttgga 991201 caaacagagg caaaagctta tccccgataa agaactattg gcgaaagaaa cgctgataca 991261 agagctttcg gcagcgtttc atatgtacca atcctgggga gaacagctgg cagccattca 991321 ggcacagctg cgccagacgt ctgcgcagac agcggcaggg ctggaacagc tcaataaaac 991381 ggatgaaaat gagctcctga atatgaacac ctcatatgat tatgaatggc agcttcagca 991441 agcggtgcag caatatgtac aggcaagaga cagaaaacgg cagcttgacg agacgtttga 991501 acttgcccgg caagagctgg aagacgcgga aaaggccgtt cgtgccgctt cgtccgcgat 991561 tcttgaaaac agccaaagaa aagataaaga agcagctctt agagcatatg atgaaacaca 991621 ggggcagcac caagagcaag cgaagctcag agaacagcta acgttttttg aaagacagca 991681 ggctaaacag aaaaagactg tcattgcagc tggtatgttg ttcatcgttc tcttttctct 991741 gctgcagcaa tggattcccg ccataagttt cggcgctgca cttattgtgt attggcttgt 991801 ttcaggaaag tcgtcttctc gaaacagccg agagacaaga cagcccatga cggatatttc 991861 accagcagaa gctgaaatgc ttagagaagc gttatgggag gatgaccgca ataagcagca 991921 ccttctcaca cagcgtgcag cgctccagca aaaagaggcg gcgtatgaaa gggtcatcca 991981 gcagtttgaa cagtgggaag ccgaaatggc gccgtccttt acacaggttg agcgttttat 992041 gaatgagctc ggatttaagg aagatccatc atttttgctt gatgcataca gcttaatgaa 992101 ggatgttaaa aaagaagtga agaaaaagca tgagctgacc atagaagcag gcaggctgaa 992161 aaagcaccgg agaacattcg aagaacgcgt cagtatgctt cttcccgtga atcagagtca 992221 ggatatctcc atttcggacg cccttcacac attgcggaaa aacattgaac gtgaaaaaga 992281 aattgagaag caaaaaaagg aaattgaaac agatattcat tatacaaagg aacagatgct 992341 tgaacttgag caagaaatac agtatttcca cgcacagatt gaacagttat ttgccgcggc 992401 tgctgcaaaa gacagagatg cgttttttgc catagccgcc atcagcaggc aattgaagga 992461 tacggagaac aagcttcatc acgtaaacgc acagcttcaa ggcgggtacc cggaggaact 992521 tgaactggcg gattccaata cgctttctga attgaaagat aagcaatttg ttgagaatga 992581 aagaaaagag cggctgactg aggagatcga gcagctccgc agccaaatcg cactgctctc 992641 agtcaaacag gaacaattag aggcttcggg aatggtctca gacctcaagc ttcaaaccga 992701 aatgcaaaaa gaacgtgtga aagaaacggc taaaaaatgg gcctccatac aaatggtcaa 992761 acaggtgatc agaaacaaat tggagcggca taaaaaaatc gagcttccgc gccttctgga 992821 gacggcagga gaatttttcc gtcctctgac tgacggaaac taccaaacca tttatttttc 992881 cgaaacggat gattcgatca tggttatgca tcgcgatggc actgtctatc atgcggaaga 992941 gctgtcacaa gggacgtgtg aacagctgta tacagcgatc cgctttgctt tggccgttac 993001 gcgccagggt gagtcaaagc ttccgttcca gcttgacgac agttttgttc attttgatca 993061 ggaaaggctg aaacgtgtat tacatgttct gtatgattta tctgaaggcg gtaggcagat 993121 tttgtatttt acatgccatg agcacgtaaa agatgcattt catagcagcc aaatcatcca 993181 tttggtgtca taaaagaggt tctatagctg aaaatcggta tgtgatatac tggtattatg 993241 taagatacgg agggagcttt aatagaatgg ctaaagggat tatgctacat gaggttggcg 993301 aacaggtgga ccagtatcta ttgattaaat cctcgacgaa agggattgca agcaatggaa 993361 aaccgtttct gacgctgatg ctgcaagacc agtcaggcga tattgaagcg aagctgtggg 993421 atgccaagca aagtgatgaa gtgacctatg cgccgcagac gattgtcaag gtcgtcggcg 993481 atgttcacca ttatcgcgga cgcacccagc tgaagctaag aaatatcaga ccggtaagcg 993541 agcaagaaaa cgtcaatatt gatgattttt tagaaaccgc gccgattccg aaaaatgaaa 993601 tgatggatac catcactcaa tatatatttg aaatgaaaaa tccgaatatc cagcgaatca 993661 caaggttttt ggttaaaaaa cacgaagctg agtttatgga ttatccggcg gctacgaaaa 993721 accaccatga gtttgtctca ggtttggcgt atcatgttgt ctctatgctg aacctggcga 993781 aagcaatagc agatttatat ccttctcttg atcgtgatct gctttacgcc ggtgttatcc 993841 tgcatgatct tggaaaagtg aaggagctgt ccggccctgt ttccacttca tatacggttg 993901 aaggcaattt gctcggccat atttccatca tggtgacaga gctttcaaaa gcggctgagg 993961 agcttcaaat cgattctgaa gaggtgttaa ttcttcagca tttgattttg agtcaccacg 994021 gcaaagcaga atggggcagc ccgaaaccgc ctatggtgaa agaagcggaa attcttcact 994081 atatagacaa tctggatgca aaaatgaata tgatggacag agcgcttgag cgcgtgaagc 994141 cgggcgagta tactgaacgt gtatttgcac tggaaaaccg ttccttttat aaaccgacat 994201 ttcataaata acttaaaaag gactgatgct gacatattca gctcagtcct ttttgatgcg 994261 tctttcccgc acataactcg tctcattccc gcatatggtt aagaataaag aatctatgca 994321 aagggggagg agcccgtgtt attttttccg tggtgggtgt atctttgtat tgtaggcatc 994381 attttcagcg catataaact tgtggcggca gccaaagagg aagaaaaagt agaccaggct 994441 tttattgaaa aagaaggaca gatttatatg gagaggatgg aaaaggagcg agaacgccgc 994501 agttctcagc agcatgaaga agaaaatcaa aaccattcca tcgcataaaa aaagctgtgc 994561 ggctcaatga gccgcacagc tttttttatt atttagaatt gcttgaagat gaagaagtgc 994621 tgttgcttgt tgaagatgta ttaaatgtgt ctttcagatc tttatctttt acttcgatgt 994681 cagccttctt catgactttt tgaacagctt cctgaacagc tgcgttgtca tttaattttt 994741 gttcaagcac ttcagatttc agttcttttt tcatatcatc atatttgccg cgttcttctg 994801 tctttttaat gatatggtag ccgtattgcg ttttgacagg atcactgact tcacctgttt 994861 ttaatttgaa tgcagctttg ctgaatgttt cgtccatttg gccttctttt gcgaaccagc 994921 caagatcccc gccttttgaa gcagagctgt ctgttgagta ttctttcgca aggtcttcaa 994981 acttctcgcc ttttttcagc tttttctcta cttcttcagc tgtcttttta tcagcaacaa 995041 ggatgtggct tgcacggatt ttgcctttta agccttccca gtactctttg atatcggcgt 995101 ctgttacttt gatgttatct ttagccgctt tttgtgtcag caattcatat tttacttgtt 995161 ctttcaggta atctttgcca tattgctttt cgagggcagt atattgatcg ccaagctgcg 995221 ttttgtattc tttcagcttg ttgtcaattt ctttatccga aactttatac ttcttgtcca 995281 atactttttc ttgcactagc tgtgtcagta cgcttgcgcc agctgttttc ttcatgtttg 995341 tgtaaagctc gccttttgtg acatcgcctg cgtctgtttt tgcgataact tctttgtcgc 995401 cgctgctgca agcactgaga gcgaggatgc ttgtagcagt gatagctgct attgcgattt 995461 tcttcattgt tttcaaacac tcctaatcat tccaaattaa attacctatg cgtatcataa 995521 catattgtgg ctttctgtaa aaagatttta aataaagggc attcgtctag tcaaactttt 995581 gctgatgaca tacttatata ttgatcaaga aaaggaggta tgtaacatga gcggaggata 995641 ctctaacgga ttcgcgttgc tcgtagtact gttcattttg cttatcatcg taggtgcagc 995701 ttacatctac taagcagccc gaggatcgct tgcaacataa gcgatccttt attttcacta 995761 gcgcctaatc gtttcaaaca tgaattgcat aacatgtaat tggtaaataa agcttattac 995821 aggaggtgct atttaagatg ggtgaagtat ttgcaggcgg attcgcttta ttggttgtgt 995881 tatttatttt attgattatc atcggcgctt cttggctgta ctaatcaaca taaaaaagca 995941 tagctgctta atcagcagct atgctttctt tcgtatttac actgtaaagg agatctccac 996001 aaacgaagag atcagtaaaa ttaatataga tacattaata aatcggaata ccttatcttg 996061 ccgctcttca ggaatctctc tgacaaggca taatgtattg gtgagcctgt ttatgaaata 996121 taaaataaac acggcagcca cgataaaata gaataaaatg atgggagatt ccccctctct 996181 ctgaactgtc ccatattaca ttaccaaata tttattaaaa aagatagaat gcaaattgaa 996241 aaatcgccac cagcaccagg gtttgactac ttttcaacaa gaatatccaa gccgtcagct 996301 tcctgatcaa taaaagcggt tttcggtgct tttatcagct tgagagccag caggaaatca 996361 ggcagacagt agccggcgtg aatgcccgag atcatgcaaa aataatgagc gtgattcgga 996421 aatgccagtg ctgcgtaaaa caataccggt gtaatcagca agaacgggct gacgagtgaa 996481 atcagcattg ttgtttttgg tatacgtttc catgtgcgca tgcgcaatat gtaaaacttt 996541 ttttctattt ttcttttttt gcagatgatt ggcaggacat ggatgacttt atgtacaaat 996601 aaaataacga cgagcaaacc gccgaataaa gatacatatt catcgcttaa gcttgtgcca 996661 ggccgcagca gctcaaaagc taaaaaggta gatataaaaa ccaaaatcat aaaacataca 996721 gcagttaata ttatgcgaac ggcgccataa tccttcatga gatttatggt cttccagcaa 996781 ttcatcaaag tcatccttcc atacatcttg aatagaatct caaaataatt tactcctccc 996841 aagagaaaaa atcaatgctt ttttaagaaa aaatatcatc cggcaggtat ttttttgaaa 996901 caagcaaaca aactgcgaaa tatggggtta gaactttctt ctcagtgaat tatcagctaa 996961 aataagatta aagatagaaa gaagtggtgt ggatggattc gatggatcat cgcattgagc 997021 gattagaata ttacatacaa ttattagtga aaacagtaga tatggacagg taccccttct 997081 atgcgcttct cattgataaa gggctgagca aggaagaagg ggaagcggtt atgaggatat 997141 gcgacgaatt gtcggaagag ctggcaacac aaaaagcgca aggatttgta acctttgata 997201 agctccttgc gctttttgcc ggacagctga atgaaaaatt agatgttcat gaaacaattt 997261 ttgccctgta tgagcagggg ctttatcaag agctgatgga agtctttatc gacatcatga 997321 agcattttga ttaactgttt acaggttcga gctcttcagc cggttcatcc gccgcactgt 997381 cctttgcttt tttcttcaat tttccgttta cgctttcaaa gtcattgtca atattggtga 997441 gtgacgtttc gaaaatttcc ataaaatcat cgccgtagat atggcgtatc atacacatca 997501 tttctgccac ttcaggaaat tttccgaata aatgatataa aggctgtgac cctttaaaaa 997561 cagcgttgcg tgtcggatca aattcctcaa gcaagctcca gaatacctcg gtaccttcct 997621 cagtcaattg gacatatgtg ttccgtttat cattcagccg tttggagaac cttaaatatc 997681 cccgttcttc cagctttttt gaaaagttga atgcggttga tacgtgcatg accccgaatt 997741 tcgcgatttc agaaatggaa gctccattca attgatacgc aatccataaa atatgatgct 997801 cattaatatt caggtcatac ggtttgagcc attgctgcca atccttctcg atcgatttcc 997861 aaagagcctt gctaagctga gccattttct gggtgaaaac cagagcttct ttcacatcat 997921 agggcggttc cactcgattc attacgtcac ctgcttctct ttttcttttt ctctattatg 997981 ccaataaaat aaagattaat aaagatgaaa atgtaagaat tttttaataa attcacaaac 998041 cattgcgacg aaagggtttt tcggccaaaa aaaatacggg tccaattttg gcccgcattt 998101 ttttcttttg aataggatat tagttttgta aggttttctc cagctgtctg attttctctt 998161 cgatatcggc aatttctttt tgcagatcct gctggtgagg cttgatctct tcctgccatt 998221 ttttaattga tgtttggagc tcgccgccca cgtctttaat aacatccgtg ctttcttttg 998281 ccgctttgat cagctggtct tttaatgcaa gcccgtctga ctttaagcgt ttgattgttt 998341 cttcaaaaga atcataattg gttttcattt tttcacgcag ctgctttcct gaggaaggtg 998401 cagtaagaag aaccgctgct cctccgatga tgccgcctac gaatagtcct gttaatagag 998461 aacgtccgct cgccattaca atcaccccgt ctttttcttc aaaataggat tcattcagca 998521 tttttcattt ttgttgaaag cctgaacttc tatacatagc ttgctttatt ttagcatatt 998581 ttttaagtga aaaggaggga gaaggttgtc tgtctttttg attgtattat cctgcatcac 998641 ccttgccttc gcttcaggcg ctgtttacta tatcaaactt ctcagccagg ctgcttctta 998701 tccgcccaag agggttatcc ggcagaaagc gcttgtttgt tcaaccggaa ccgcctttac 998761 actatgtctt atctttttca caaaactcct cgcttaaaac atgctgacat gctgcgggcg 998821 ctctgttcaa aaaaacctct cccggaagcg gaagaggttt tgtgtgacaa ttatttagca 998881 gcttccataa agcttgaacg ccttaaaatg gtttgcacaa tcggataaat aatgatcatt 998941 gagattgtat tcagcacagc ggccggcaga acaacagccg cgaacaatgc ggcgaaaccg 999001 cccggtaaac cgacgatcaa taaagctgac gatagaaaca caattcctga taagatggtc 999061 ccgatcactg tcagcacagc ggctgcacct gttttccggc tctttctgaa caagagaaac 999121 agggagaaga acagaaacgc tgatacgggt ttatcaatga tgttagggat ctgtccggct 999181 ggaaacgcgg ttgtaagcgc ggaaatgatt ccggtcacga tcccgatgac gagtacattt 999241 tgcacccgcg ggaacagcag aatgcccatg aacatcatga tcagcatcat atctggtttc 999301 atgccgccta aaaagggcgg aataatggaa tgaagcgctg cgccgattgc ggcaaacaga 999361 gccataatga ctaactcttt tgttttcata actatgctct cctctgctaa gctttttgcc 999421 ctccaataat atgctcatca tttattgcga aggctttaca gaatgtgtta tgcaaacagt 999481 ataccaaacg gacggtttgc atagccagac tttttactca ttttcctgct ggaatttctt 999541 catgaacgca gctaattttt cacagtcttc gagagagacc gcgttataaa tagaagcgcg 999601 gcagcctccc accgaacggt gtccgccaag gccgatcatc ttcgcatctt ttgctttctg 999661 aacgaatgtt ttcgttaatt cgtcatcccg aagcgtgaat gtgacattca tgcgtgagcg 999721 gctgtctttt ctggcatgtc ctttatagaa gccgttgctt tcatcaatac agctgtagag 999781 aacctgcgct ttttgttcat tgcgctgttc aacagcttcc acaccgccgt tttccttgag 999841 ccattccaga acgaggctca gcatataaat cgcaaatgtc ggcggagtgt tgtagagtga 999901 atccgctttg acatgcgtgg aatatttcaa gatttttggg acgttcgcat tttcattttg 999961 cagccagctt tttttcatga tgactacagt cacgccggaa gggccgaggt tcttttgggc 1000021 gcctccgtag atcacatcaa atttggacac atcgattttt ctgcttaaaa tatcgctgga 1000081 catgtcggct acgagcggaa ttggagaatt cggaaactcc tgccactgag tgccgaaaat 1000141 tgtattgttg gatgtgatat gtaaatatgc gccgtctttt acatccgtaa ggtcaacctc 1000201 tggaatataa ctgtaattgt ctgtttcact tgtagcggtg atagacgtgt tcccgaacag 1000261 tttcgtttct gccagtgctt tttcagacca agcgccggtc atcacaaaat gtgcggtttt 1000321 ttcaggtgtt aaaaagttca tcggaagcat tgagaattga aggcttgccc cgccttgaag 1000381 aaacaagata tcgtaatctt ccggaatgcc catcagttcg attaagaggc ttttcgcttt 1000441 ttggtgcacc gcttcatact ctttgctgcg gtgggaaagc tccataacag acatgccgga 1000501 ttcgttaaaa tcaataaatt ctttctgtgc tttttgcaga acttccagtg gcagcgctgc 1000561 aggacctgcg ttaaaattcg ttgtacgttc cattatgatc tctccctgtt ttccacgtta 1000621 atgtataaaa taatacaatt atcctatcac aaaaattcag ttttttgata aaaaattaga 1000681 attatcaaaa gaaattgacg gatgtttgcg aaatgttcac aaaataaaat aacctcatct 1000741 tatgatgagg ccaggcgttt tgcgatagag gaagagatgt tctgcagatc ctccggttta 1000801 taatcatcag catgcgtttt ccaaaccgct ccgaatccat ctccttttcc gtagcgaggg 1000861 ataatatgca tatggtagtg gaacacagat tgtccagctt tttcgccgtt attgttcagc 1000921 gtatttaagc cgatcggttc aaattcatcc cggatagcgc gggcgatttt tggaacagca 1000981 tggaaatatt gttttgctaa ttcatctgta aattcatata cattctcaat atgtgttttc 1001041 ggaatgacaa gcgtatggcc ttttgtcact tggctgatat caagaaaggc aagtacatgt 1001101 tcatcttcat acaccttcgc tgatggaatg tcgccggcaa taattttaca aaagatacaa 1001161 ttctctgcac aatgcatgag ggttcctcct tatgaaattg tttagtatgt atacattcat 1001221 cgtaccacag aaatgcagaa aatagaaaac aggatgaacg gcgagcgttc accctgaatg 1001281 cagaggaaga gcttatatga agaaaatgtg ttatgccttt ggtaagcacc tcatttgtca 1001341 ataaaatgaa gacttgttta atgcctaacg attcctgcga taaacacctc atttgacaat 1001401 ttgcttcata catgaagaat tcatcaattc agtgaagaga aatggtttga gcattggaca 1001461 tgtttatttt ctatccaact gtttctaaga cgtctttgac aaacacctca tttttcagtt 1001521 gatatgcttt tcctctacaa cttttatgat gtccagaacc ctgtctcttt atgacagcaa 1001581 attcatcatt tgttaaaagg gaattgtttc aaatcaggcc ttgtttttgg tactatgaag 1001641 aaaaacacta taaggggaga aactatgtct ctgctatcgg taaaagactt gaccggcgga 1001701 tatacaagga atccggtttt aaaaaacgta tcattcaccc ttgaaccgaa tcaaattgtc 1001761 ggcttaatcg ggctgaatgg tgctggtaaa agtacaacaa tcagacacat catcgggctg 1001821 atggacccgc ataaaggttc aatcgaatta aacggtaaaa cgtttgctga ggatccggaa 1001881 ggctaccgtt cacaatttac ctatatacct gaaacacctg ttttatacga agaattgacg 1001941 ctgatggagc atcttgaact aacagccatg gcatatggac tgtcaaaaga aacgatggag 1002001 aaaaggctgc ctccgctact aaaggaattc cgaatggaaa agaggctgaa gtggttcccg 1002061 gcccattttt ctaaaggaat gaagcagaag gttatgatta tgtgcgcatt tttggcagag 1002121 cctgcgctct acattattga tgagcctttt ctagggcttg atccgcttgc cattaacgcg 1002181 ctgcttgaac ggatgaatga agcgaaaaaa ggcggggcga gcgtgctgat gtcaacacac 1002241 attttggcaa cggcagaacg ctattgcgat tcgtttatta ttttacataa cggcgaggtg 1002301 cgggcgcgcg gcacgctgtc agagctcaga gagcagtttg gaatgaagga cgcggcgctg 1002361 gacgatttgt atcttgagct tacaaaggaa gacgctggcc atgaataata tgcttgatat 1002421 ttggcagtcg cggctgcagg agcatatcaa agaaacaaga acatacatga aatatatgct 1002481 caacgatcac ctcgtcattg ttttgatttt ttttctagcg ggcgctgcaa gctggtacag 1002541 caaatggata cgggacattc ccgctcactt tccgtccttt tgggtgatgg ccgtgctgtt 1002601 ttcgctcgta ttgacaagct cttatgtgcg aacgcttttg aaggaggctg accttgtttt 1002661 cttattgcct cttgaagcaa aaatggagcc ttacttgaag caggcgtttg tctacagcta 1002721 tgtgtctcag ctgtttccgc tgattgcgct gagcatcgtt gcgatgccgc tttatttcgc 1002781 agtcactccg ggagcttcgc tcgtatcgta tgccgcggtc tttgtccaac tgttgctgct 1002841 gaaagcgtgg aatcaggtaa tggaatggcg aacgactttc caaaacgacc gcagcatgaa 1002901 acggatggac gtcatcattc gctttgcggc gaatacactc gttctttatt ttgttttcca 1002961 atctgtttat atgtatgcgc ttctcgtcta tgtcattatg gctgttcttt atctgtatat 1003021 gtcttccgca gcaaaacgga aaacatttaa atgggagagc catattgagt ccgaattgag 1003081 acgaaagcag cgtttctatc ggattgccaa cctgtttact gatgtgccgc atttgcgaaa 1003141 gcaagccaaa cgcagagctt atctcgactt tttgctgcgg cttgtgccgt ttgaacagcg 1003201 caaaacattt gcctatatgt tcacccgcgc ctttttgcgt tcgagcgatt atttgggcat 1003261 tcttgtcaga ttaacgatcg ttttcgcgct gatcattatg tatgtctcag ccagcccgct 1003321 gattgccgcg gttttgactg tgtttgccat tttcattacg ggcattcagc ttctgccgct 1003381 cttcggtcac tttgaccatc tggcgcttca agagctgtac cctgtgcaaa aagaaacaaa 1003441 gctgaaaagc tatttctctc tattaaaaac tgcacttagt attcaagcgc tgctgatgtc 1003501 tgttgcatct gcctatgcag ccggcttgac cggttttctg tacgcgctga tcggttctgc 1003561 cgttctgatt tttgttgttt tgcctgctta tatgacgacc aggctgaaaa agcacggaaa 1003621 gctgtgaact gaaaagaggt aatcaaatga cagataatca gctgctgatg caggaagctt 1003681 tggaatggaa aatgcatttt ttgcgaaagg attccatgtt tgaacgcttt tcgaagcgtg 1003741 tccagacgaa ggtgaatgaa cggattcctg aaaaaatcca tacggtcgtc accgagagtg 1003801 tgaaaaaaat ggtagaagcg acaatggccg gctctaatat catcacctat aaaaaggata 1003861 caagtgcact gtcgctcagt gaaaaaaacg aattggcgaa aaaaacgatt gtttcttatc 1003921 aaaaagtggc agctgctgag ggagtcggca ccggagcggg cggcattttt ttaagcattg 1003981 ctgattttcc gctgctgctt tcaattaaga tgaagtgttt atttaccttg tcttccattt 1004041 acggctttga tgtcaaggat gcacaagaaa ggatattttt gctgctcgtg tttcagcttg 1004101 cgttttcgag tgatgatggc cgtaagtcgc ttttttctgt catcgaaaat tgggagacgg 1004161 agaaaaagag catcgactgg agagtgttcc agcaggaata tcgcgattat atcgacgtcg 1004221 tgaagctttt tcagcttttg ccgggcgtag gagcggcagt cggcggaatt gccaattata 1004281 agctgcttgc tcagcttgga gaaacggcaa gacatgtttt tcatctgagg atattaaagg 1004341 aaacagccgg agaataaaca ctccggctgt ttttttatag ctgatgatag gtgatcgcag 1004401 cgccggcaag gaccttggcc gctgtcagca tggctttttc gttgatatca aatttcggat 1004461 ggtggtggga atagactcgc tctggctgtt cgggagcggc gcctgtaaag aaaaaagtgc 1004521 ccttcacgtt ttgtaagtaa taagcaaaat cctcgccgcc catttgtggt tcaccgtcaa 1004581 tgacctgctg aacgccctcg gtattctttg cggtgctcac caagtggttc gtttctgcag 1004641 gatggttcac aaccgctgga taaccctgtt cataggtgta ctcataggac gcgccgtgca 1004701 tgctgcatat tccttttaca accgcttcaa tttctttctc cagaatgtcc cggacatttt 1004761 catcaaaaga acgcgctgtg ccgatgagta ctgcttggtc tgcgatgaca ttaaacggat 1004821 tgtcggcgat gaaggagcct gtcgaaatga cggcggattg aatcggattg actttgcggc 1004881 tgacaatgtg ctgcaaagag gaaacgattt gcgaaccgat taggacggcg tctttagtat 1004941 catgcggatg agcgccgtgg ccgccctttc cgaagacttt aatcgtaaat cggtctgccg 1005001 ccgccattac ggcgccgggg cggcagagaa tagttccgag cggctcagtt gcccaaagat 1005061 gagtgccgaa tatcacatcc gtgttttcga gacatccgtc atcaatcatt ggctttgcgc 1005121 ctccaggata atattcttct gcatgctggt ggatcatcac aaatgttccc ttcagttcat 1005181 gtctgttttg gtgaaggacc ttggccactg cgagaagagc tgcggtgtgg ccgtcgtggc 1005241 cgcatgcatg catgacacca ggcactttgg aggcgtaagg gacatctttt tcatcttgaa 1005301 tggggagagc gtcaaagtcg gccctcaaag cgactgtagg gccgggttcg cttccttcta 1005361 tatttgctaa aacccctcta ccgccaacgt ttgtgcggat tgggactcct aacgattcat 1005421 aataggaagc aataaatgcg gcggtttttt cttcttgaaa tgagagctca ggatacatat 1005481 gaaaatggcg cctgatctca accatttctt caaaacagcc gtcgagctgt ttgtttatct 1005541 ctttctgcag tgtggatatg gacaaagccg cttccccctt ttctatgctt ttccatgatt 1005601 gtatagaaaa agtctgaata tttcaactca tgctgtttta aagcatcatc acagctgcga 1005661 gggttgtcac caaaaggcca atcgcgacgg gaatgaagtt ttttctggca agctcaaaag 1005721 gatcaacttt gcaaatggcc gcggcgggaa tcaaagccca tgggaccagt gttcctccgc 1005781 ccacccagat ggcagagatt tgtccgagcg cggtcagaat agcgggatcg gcatggagag 1005841 cggacgaaaa gagctttgcg atggagccgg cgagagaaat gccagaaaat cctgagccgt 1005901 caaggcctgt tatggctcca gcggcagtta atgcagtggc ggcaagctcc tttgacatag 1005961 gcatcatatg ggataaagca atgccaagat cgttgacaat gccgtgggaa cctttaggga 1006021 gtgaagtgcc cagtatgctt tcatagcctg agtcgccaag ataaaagaaa gcggcaatcg 1006081 ggatgacggg gccgaaaacc ttaaaaccga acttaaatcc gtcaataaaa tagccggtga 1006141 ttttttcaag ccctttatgc ttatacacga aaaaatgaac ggtaaagagg atacaaattg 1006201 cagacccgcc aattaacgcg gttgcatcat ttccttgtag gttaaacaag agcatgcagg 1006261 cgatatctgc aagaaaggca agcggaatca aaaaagccag tatggaccgc aggcgttttg 1006321 gcaagtacag cgagttgtct tgttcgccgg aaagaacggg ggaaaaagaa gtgggatgct 1006381 cctgtttttt gcgttcgcgc tgaatcatga taaaggcagc agttgttgtt gtcacaccca 1006441 taatcagcac aagcggaata ctggccgaga cgacatcacc gactggaatg cctgctgcat 1006501 ccgcagtcag ctttggcgcc gcctgaatga caaagtctcc tgacagggca aaaccgtgtc 1006561 cgaataagtt catggccatg gccgcggcaa gaggcgtcaa accggcacgt gcggctgcgg 1006621 ggagcaggac ggcgccgatc aaagcgacac ccggagaagg ccagaagaat agagaaatgg 1006681 cgaacatcag gcctccaatc agccaatagg cagtcacagg ccctctcaca aggcttgcaa 1006741 agggagaaat catcgcttca tttatccctg tttttgttaa caaatcactc attgaaacga 1006801 taaagcaaat gatgaaaatc gtgggcagca gttcgccggc cgcatagata aagctgtgga 1006861 ataaactgct gacagaagct gaaagtgaat ggctggccca tagcgatatg ataaaaatgc 1006921 cgaatagaga aataaatgtc gtgtcttttc tcagcagcat aaataggata attgcaccga 1006981 taaaaaacac atacagaaca tggacaggca aaatcccgac ttccatcatc gatcactcct 1007041 tccgcttaca gattattcat aggcgggcgg aaggtgccgg gacagagggg agggttatga 1007101 tggaagatga acattgatct gtttcagctg ctcaatcaga tgatgcctta atcctctatt 1007161 cgctttttgc agatgttttg ggaagcattc aggagaaaaa atgacgcacc cttcagcaag 1007221 ccagtttttt ctataggcga tgatgctttc cgatggctct atatgagtta tcctcgtgct 1007281 gcatctcgta ctcatcaaat ccgaactgaa aaccgcagca cgggcagatt tcatgagaat 1007341 gattgccttc atgatcatat ggcggttcag ccaatcctta aacccgcaga ctgggcaagt 1007401 atgcttcatt ttgctttcct cccaataaaa taagctgccg gacatgccgg cagctattcg 1007461 acagcgaaat atgtggtgac ataggaaggc cgggagaaga tcgacgttgt gtcaattccg 1007521 gcagatgtat cgcgtttttt gtgggcttct ttgtaagaac cggactgctg ccagtcttga 1007581 aaggcgcttt ccgtttccca caaggtcaga atgacatagg tgtcactgtc aagcggacgg 1007641 agcactcgaa ttgcttcaaa gccaggctcg ttttcgactt ttcccgctct gtttttaaat 1007701 ctgttttcaa acagcggacg cccttcctga gtaacggcaa tattgttcaa tactgcaaaa 1007761 ccgggatgtt tgatctctcc gacttggtca atgacttcat aagcgtgtgg tgcctggaaa 1007821 acggtatctc cgtttgtttc atgaattaaa atggcgtttt cctgcccctg catcaaaagg 1007881 atattttctg agggatgctt ctgtacgatc gtttttaaaa aatcggctgt cccatatgta 1007941 atataaacct tcatatcagc cacctcctgc ttgctagtat atcaaaacaa tggtataagt 1008001 ttctattggc gagtgcttcg aacataattc caaacaattt ttcccatact acctttagaa 1008061 aggcgaggtg agttcatgtt taagataaag aaaaagaaac tttttatacc tatcattatt 1008121 ttagtgttaa ctgcttttct cgctttaata ggatatattt caattatttt tctcggccat 1008181 tatgtcatag atgaaaaaaa gcttattctt catgcttctt caaaaattgt tgatcaaaac 1008241 ggagatgagg ttgcaagcct gtatacagaa aatcgcgagc cggtctcgat caatgagatt 1008301 cctaagcagg tcagagaagc gtttatcgct gttgaggata aaaggttcta tgagcatcac 1008361 ggcattgatg caaaatccgt cggaagggca gtgtaccgcg atatattagc aggcggaaag 1008421 gtggaaggcg gaagcacgat cacccagcag cttgccaaaa atatttttct gacacatgac 1008481 aaaacatttc taagaaaaac aaaagaagtg atcattgcga ttaatcttga acgggattac 1008541 agcaaggaca agctgcttga aatgtattta aaccagcttt acttcggaca cggggtttac 1008601 ggcatacaag cggcgtccca ctattatttt aataaagaag taaaagattt gactgtatct 1008661 gaaggcgctg ttttggccgc tattccgaag gcgccttcta cgtactctcc aattttgcac 1008721 cctgataaaa ataaggagcg gcgtgataca attctaggta tgatgaatga ccaaggctat 1008781 atcagtgcga aagaggctgt caccgcacag ggccggacgc ttggactgca tgtgaagaaa 1008841 cagtcggaaa caccttggtt tgacagctac attgaccttg tgatcaaaga ggcggaagac 1008901 aagtattcca tttccggaga gcagcttctt caaggcggat acacgatcaa ggtgccgctc 1008961 gattcgaagc tgcagaagac ggcttaccag gtgatgaaag agggaagcta ttatcccgga 1009021 acagatcaga atgccgaggg aagcgcggtc tttattaata acaagacagg cggtgtagaa 1009081 gcggccatcg gcggaaggga ttacacatcc aaaggatata accgtgtcac agctgtccgc 1009141 cagccgggtt ccacatttaa gccgcttgct gtatacggac cggcgatgca ggaaaagaaa 1009201 tttaagccat attctctatt gaaggatgag ttgcagtcct acggagatta tacgccgaaa 1009261 aactacgaca gccggtatga gggcgaagtc actatgtctg acgccattac gtacagcaaa 1009321 aacgcgccgg ctgtctggac gctgaatgag atcggcgtcg aaacagggaa atcttatttg 1009381 aaagcaaacg gcattgatat ccctgatgaa ggccttgctc ttgctctagg cggcttggaa 1009441 aaaggcgttt caccgctcca gcttgccggc gcgtttcata catttgccgc gaatggaacg 1009501 tatactgaac ccttctttat ctcgagcata atagatgaag acggagaaac aatagccgat 1009561 cataaagaag aaggaaagcg ggtattcagc aagcagacgt cttggaatat gacgagaatg 1009621 ctgcagcagg tagtcaaaaa gggaacggcc acgtccggca cctatcacgg cgacctggcg 1009681 ggaaaaacag gttcaacatc ttatacaggc gtctccggcg cgacaaagga cgcctggttt 1009741 gcaggctata cgccgaaaat aaccggggca gtctggatgg gctatgacaa aacggatcaa 1009801 aaccattatt tgaaagccgg gagctcatac ccgacgcggc tgtttaagga tattttgaca 1009861 caggcaggag aaaccggtca tgtgttcaca aagcctaaaa acgttaaaga actggaaagc 1009921 ccgattgagc tgaagccggt caaaacactc acagccgatt acacatttaa agcagcgggg 1009981 ctctttacta ttgaattaaa gtgggacgct caagaggatg atcgggccgt atacagaatt 1010041 tatgtaaaca aggacggcga ggagacgctt cttgattcgg ttgaagggaa gggaagctat 1010101 gaaattcctt atgccaactt attttcgggc gcgtcttata aaattgtgcc ttataataca 1010161 cagacaaaaa gagaagggga aggaaccgat tacgttcagc caaaattgtt ttcctcttaa 1010221 tggaattcgg cgattttttg aactttgagc tacatttcta taccatttgc ctaaaacaag 1010281 gtatagtgta ataagtcaag aaatacgaac gtatggttgc cgtatgaaag gtggaaatca 1010341 gatgagtaaa cgagaaacgt ttaacgagac gtttttaaaa gctgcgcggg gagaaaaagc 1010401 ggatcacacg cctgtgtggt atatgaggca agcagggcgc tcacagccgg aataccgcaa 1010461 gctgaaggaa aagtacggat tgtttgagat cacacatcag cccgaacttt gtgcgtatgt 1010521 cacaagactg ccggttgagc aatacggagt cgatgctgca atcctttata aagatatcat 1010581 gacgccgctg ccgtcaatcg gtgtggatgt tgaaatcaaa aacgggatcg gtcctgtgat 1010641 tgatcagcca atccggtctc tggcggacat tgaaaaactc ggccagattg atccggaaca 1010701 ggacgtgccg tacgtgcttg agacgattaa actgcttgtc aatgagcagc tgaacgtccc 1010761 gctcatcggt ttctcaggtg cgccttttac gcttgcaagc tatatgatcg aaggcggccc 1010821 gtcgaaaaac tacaataaaa caaaagcctt catgtacagc atgccagatg catggaatct 1010881 gctgatgtcc aagcttgccg acatgatcat cgtgtacgtg aaagcgcaga ttgaggcagg 1010941 cgcaaaagcg attcaaatct ttgattcgtg ggtcggcgca ttgaatcagg cagattacag 1011001 aacatacatc aaacccgtga tgaaccggat cttttcagag ctcgcaaagg agaatgtgcc 1011061 gctgatcatg tttggcgttg gcgcaagcca tcttgcaggt gattggcatg accttcctct 1011121 cgatgttgtc gggcttgact ggagactcgg cattgatgaa gccagatcaa aaggaattac 1011181 taaaacagtg cagggcaacc tggacccgtc cattttgctt gcgccatggg aagtcattga 1011241 gcagaaaacg aaggaaatac ttgatcaggg tatggagtca gacggcttca ttttcaatct 1011301 tggccatggg gtatttcctg atgtcagtcc cgaggttttg aaaaaactga cagcatttgt 1011361 ccatgaatat tcacaaaaca aaaaaatggg tcaatattcc taagcatatc ttttggtatc 1011421 ttaatgatat cctgtcaaaa tgtttgtatc agatcattaa agagggtgta aacagtgagt 1011481 agaaagaaaa tggggcttct cgtgatggcg tacggcacgc cttataagga agaagatatt 1011541 gaacgttatt atacacatat cagaagaggc agaaagcctg aacctgaaat gcttcaagat 1011601 ttgaaagaca gatacgaagc gattggcggc atttcaccgc ttgcccaaat cacagaacag 1011661 caggcgcata atctggaaca gcacttgaat gaaattcagg atgagattac gtttaaagcg 1011721 tatatcggac tgaagcatat cgagccgttt attgaagacg ccgtagcaga gatgcataag 1011781 gatggcatta cagaagcagt cagcatcgtg ctggcgccgc atttctccac gttcagcgtt 1011841 cagtcctaca acaaacgcgc caaagaagag gctgaaaaac tcggcggctt aacgattacg 1011901 tcagttgaaa gctggtacga tgaaccgaag ttcgtgacat attgggttga ccgagtgaag 1011961 gaaacatatg cgtcaatgcc tgaggatgaa agagaaaacg caatgctcat cgtatccgca 1012021 cacagcctgc cggaaaaaat caaagaattt ggagacccgt acccggacca gcttcatgaa 1012081 tcggcgaaat taattgctga aggcgcaggc gtttccgaat atgctgtcgg ctggcaaagt 1012141 gaagggaaca cgcctgatcc ttggctcgga cccgatgttc aggatttaac acgtgattta 1012201 ttcgaacaaa aaggctatca agcatttgta tatgttcctg ttgggtttgt cgcggatcac 1012261 ttagaagtgc tttatgataa tgattatgaa tgcaaagtgg ttactgacga tatcggcgca 1012321 agctattacc ggccggaaat gccaaatgcc aagcctgaat ttattgatgc tttggcaaca 1012381 gtcgtattaa aaaaattagg acgttaaaga aggcgatgaa catgagtgac ggcaaaaaac 1012441 atgtagtcat catcggcggc ggcattaccg gtttagccgc cgccttctat atggaaaaag 1012501 aaatcaaaga aaagaatctg ccgcttgagc tgacacttgt tgaggcaagt ccgagagtcg 1012561 gcgggaaaat ccagactgtc aagaaagacg gctatatcat cgaaagaggg ccagactcat 1012621 ttctggaacg aaagaaaagc gccccgcagc ttgttaaaga cttaggtctt gagcatttgc 1012681 ttgtcaacaa tgcgaccggg caatcctatg tgcttgtaaa ccgcaccctg catccaatgc 1012741 cgaagggcgc tgtaatgggg ataccgacaa aaattgcgcc gtttgtttct acgggtctgt 1012801 tttccttgtc cgggaaggcg agagctgcta tggatttcat cctgcctgca agcaaaacaa 1012861 aggatgatca gtcattggga gaattcttcc gcagacgtgt cggagatgaa gtggtcgaga 1012921 acttaatcga gccgctacta tcagggatct acgcaggcga cattgacaag ctcagcctga 1012981 tgtcgacatt tccgcaattt tatcagacgg aacaaaagca tagaagcctg attctcggca 1013041 tgaaaaaaac aaggcctcaa ggctcaggcc agcagctgac ggcaaaaaaa caagggcagt 1013101 tccaaactct gtcaaccggt ttgcagaccc ttgtagaaga gatcgaaaag cagttaaagc 1013161 tgacgaaggt gtataaaggc acaaaagtga ccaaacttag ccatagcggc tcttgctatt 1013221 cgctcgaact ggataacggc gtcacacttg atgctgattc agtaattgtg actgctccgc 1013281 ataaagcggc tgcgggaatg ctttctgagc ttcctgccat ttctcatttg aaaaatatgc 1013341 actccacatc cgtggcaaac gtcgctttag gtttccctga aggctccgtc caaatggagc 1013401 atgagggcac gggttttgtc atttcaagaa acagtgactt tgcgatcaca gcctgtacgt 1013461 ggacgaataa aaaatggccg cacgcagcgc cggaaggcaa aacgctgctt cgggcatatg 1013521 tcggaaaagc cggagacgaa tccattgtcg atctatcaga taatgacatt atcaacattg 1013581 tgttagaaga cttaaagaaa gtcatgaaca taaacggcga gccggaaatg acatgtgtaa 1013641 cccgatggca tgaaagcatg ccgcagtacc atgtcggcca taagcagcgt atcaaggagc 1013701 tgcgtgaagc acttgcatct gcgtatccgg gtgtttatat gacaggcgct tctttcgaag 1013761 gtgtcggcat tcccgactgc attgatcaag gaaaagctgc cgtgtctgac gcgcttacct 1013821 atttattcag ctaaaacctc cgctttatcg cggaggtttt tttgatgtgc aatggcaata 1013881 ttgtgtaaaa aatgattgaa ttgaacagca ggttatgata catttgcata tgtacttaat 1013941 gactaaaatg ttcaaacggt cagtttcgag gtgaatacaa tgtcaataga tcgaaaaaag 1014001 ctcattttgg aggcggctac aaagtctttc acgcagttcg ggtataaagc gacgacaatg 1014061 gatcttgtcg caaaacttgc gaacgtgggg aagggaacca tttatacttt tttcaaaaac 1014121 aaagaagagc tgtttgacga gattttcact actttattaa aggaaatgaa gcaaaaagcg 1014181 gatgaagcga tggagccgag ccttccgttc catgaaaatg tgcacagagc gctgtttgcc 1014241 attctggagt tcaggaaaac acatcagctg acgattaaaa ttttccaaga gaatgccgag 1014301 attggtacaa tggcagttca ggaagtgatc cagaaaatgg agcgatccat cctgtcttat 1014361 atcaaaagca agattgaaga cgggatcaaa agcggcgcaa tcaagccgtg cgaccctgag 1014421 ctgacagcct ttgtgatgct gaagctttat atcgcgctca tttttgactg ggaaaaacaa 1014481 caccccccgc ttgataaaga gacaattgcg ggactgcttg aattgtatgt tgtcaaagga 1014541 ttgtcagcga actagataat cctttctctt tgcaagaaaa tgaccatttt ttatgatgag 1014601 tcagttttag aatggaggca tcaggatgaa cacaatacga agtcagtgga aagacatcgt 1014661 aacaagtaaa aaattattga ttcccatcat cgccattttg tttgtcccgc ttatttacag 1014721 cggcgtattc ttaaaggctt attgggaccc gtacggcaca gttgaccagc tgcctgtcgt 1014781 tgtcgtcaac caagacaagg gagcaacgta tgaaggagaa aaacttcaaa tcggtgatga 1014841 tctggtcaaa gaattaaagg ataataacaa ctttgattgg catttttcca atgatctcga 1014901 ccaatcgtta aaggacttat tgaatcaaaa atattattta gttgtcgaga ttcctgagga 1014961 tttttctaag aatgccagca ctgtattaga caaaaatccg aaaaaattgg atctgaaata 1015021 ccatacaaat gcaggttcta actatgtagg ggcaacgatc ggcgaaaaag cgattgataa 1015081 actgaaagcc tctgtttcaa aagaagtgac cgagcaatat acgaaagtta tttttgataa 1015141 ctttaaagat atcgcaaaag gtttgagcga cgcgagcagc ggcgcgaaaa aaattgatga 1015201 cggcacaaag gatgcgaaaa acggaagcgc ccagctgaaa gaaaatctgg cgaagctgaa 1015261 ggaaagcacc gctaccatca gtgacaaaac agcgcagctt gcagatggag cggctcaggt 1015321 gacgagcggc atccaatcac ttgacagctc gctcggtaaa ttccaggaca gcagcaacca 1015381 gatttatgat aaatctagtc agcttgcagc aggatcaggc gagctgacaa gcaagatgaa 1015441 tgaacttctt gccggacttc aaaatgtgca gaagggtacg cctaatctta ctaacgggtt 1015501 ggatcagctc aacagtaaag tccaagaagg ttctgagaaa gcggcaaaag cggaaaagat 1015561 cattaatgcg ctcgatttaa cgaagcttga aactgctgta aacaatctgg aaaagtcaga 1015621 aactgcgatg aaggaattca aaaaacagct gactgacttt gaaaacagtt tgaaaaaccg 1015681 tgatcaggca tttaaaaatg tcatcaattc gagtgacttc ttaacagcgg agcaaaaaag 1015741 ccagctgatt aattctgttg agaaaaagct tccgcaagtt gatgcgcctg attttgatca 1015801 aatattaagc cagctaccta cagctgatca gctgcctgac atcgcaacga taaaaagctc 1015861 tcttgaagac gtgaaagcgc aggtggcgca ggtgaaagcc atgccggaag ctacatctaa 1015921 gctttataac ggcgcaaaaa caatccaaga tgcgattgac agattaactg agggagctga 1015981 taagatatac aacggttctc agaagctgac agatggccaa actaaactga cagcgggcat 1016041 cggtgaatat aataagcagt tcgcaaaagc aaaagcgggc tcagagcaat tggtgacagg 1016101 aagcagccaa gtatccggcg gattgtttaa gctgttagac gggtctaaac aggtccaaag 1016161 cggatcatca aaacttgcag acggatctgc atcacttgat acaggtttag gcaagctatt 1016221 ggacggcaca ggagagctgt ctagtaagct gaaggatgcg gctgaccaaa caggagatat 1016281 cgatgctgat gatcaaacat acggcatgtt tgcggatccg gttaaaacca aagatgatgc 1016341 cattcattcc gttcctaact atggaacagg gctgacacct tatatcctgt caatgggctt 1016401 gtatgtcggc ggcatcatgc tgacggttgt cttcccgctg aaggaagcgt caggacgtcc 1016461 gagaaacggt tttgagtggt tcttcagcaa attcaatgtc atgatgcttg taggaatcat 1016521 tcaatcattg attgtggcga cggttcttct attgggaatt ggtcttgagg tagagagcac 1016581 gtggagattt tacgtgttta cgatcattac gagtctcgct ttcctggcga taattcaatt 1016641 tttggctaca acgatgggca acccggggcg atttatcgca gtcattattt tagtgctgca 1016701 gctgggagcg agcggaggaa ccttcccgct ggaattgctt ccgaatttct atcaggtcat 1016761 ccacggcgca ttgccgatga cctacagcat taacggattc agagcagtca tttcaaacgg 1016821 tgactttggc tacatgtggc agatggccgg cgtcttaatc ggcattgccc tcgtcatgat 1016881 tgcactaagc attacttact ttacaatgtt aagccggaag gaagaaacat cagaagaaca 1016941 gccggcttca taaagaaaaa gaacttgttt ccttggaaac aagttctttt tttgttacat 1017001 cccccattta ataagcaatc ctgtataggt taatccgccg ccaaacccga aaagcaaaac 1017061 gatttgatct tttttcagct tcccggcttt cactgcgaga tcgagcgcca aaacaattga 1017121 aaccgaagac gtgtttccgt agtgctcaac actagtgagc gttttttcaa tcgggaacgg 1017181 tgttttttca caaattgact cgatcatgcg caagttggcg ctgtgaggaa caaaccaatc 1017241 gagatcatcg gagctgagtc ctgctttatg taaaagccgt tcaaattcgc cagggacggt 1017301 tcttgcggcc catttatata cctcgcgtcc gttttgcacc atttttccgg aaccgacaag 1017361 ctgcacaccg tttatttcat ttcgcagtcc ggcacgatac aaaatatcgc cgccgttccc 1017421 gcttgttcct tgtacagacg caagaaatcc cggcgtctct tcatctcgtt ctactaacag 1017481 cgcacccgcg gcatcgccga acagtacgca tgtcgttcga tcggtataat cggttacctt 1017541 tgataacgtc tctccggcga tgacgagaat tttttgatga aggccagatg tgatcaatcc 1017601 atttgccaaa tggaggccgt atgtcagccc ggcgcatgtc gcattaatat ccagcgcgcc 1017661 ggtgctttcc cagccgaaat attcctgtac gcggcatgcc gtactcggaa aggcgtaatc 1017721 ggatgtggtt gtggcaacga ggatcatatc gacatcatca agcgttcctt tataacggct 1017781 cttgagattc ttcaccgctt ctatgcataa atcagaggta aattgatgtt catccgcaat 1017841 ccggcgttct ctcattcctg tgcgctgaac gatccattca tcagaggtat caacgatctt 1017901 ttctaaatct gcattggtta aacgtctgct cggcgcatag gtgccgatag ctgtaatttt 1017961 tgcttttgac atatgaatca ctccttatgg tcagattata acactagata ttagtatctg 1018021 gtactaaaaa gaaggttttt ttacaaaaaa agagaagtgt agataggaat ctatgaaaaa 1018081 gaaaaaggag gctgaaaaat ggtcagtcaa gaagcagtag tctttttggc attatccggg 1018141 gctattgcgt ttctgttgcc aatcgggctg attgtatggt ttaagcgaaa gtatggtgcc 1018201 tcgcttaaag tgttttttat tggcgctctc acgttttttg tcttcgctca gctgctggaa 1018261 ggcggcgttc atgtttatgt actgcaagtg aatgaaatga cgaaagaagc gatgcagcat 1018321 ccattatggt atggcattta cggctgcttg atggccggca tttttgagga gtgcggaagg 1018381 tatttgatga tgcgattttt tatgaagcgc catcatactt gggcagatgg tctggctttc 1018441 ggggcaggcc atggcgggct tgaagccatc ctgattacag gcttgtcctc tatctcactt 1018501 attgtatacg catttgcaat caatagcggg acgtttgaac agcttttggt caatggcgac 1018561 gtcaaacagg cgcttttgcc gatacaggag cagctgctgc atactccttc gtatgaatgg 1018621 atgctgggcg gaatagaaag aatcagtgcc attgccgtcc agattggtct gtctctgctt 1018681 gttttgtacg cggttaaaaa ccgccggccg ctgtttttgc tgtattctat tcttttacat 1018741 gcactgttta atgtcccggc ggttttatat caaagaggaa tcatagagca tgctgcagct 1018801 gttgaaatca ttgttgctct tatagcggct ttatcagttt attggattgt aaaagcaaaa 1018861 agggtgtttc aataaaaggt ccaagcagca gcaatgcccg cttggaaaaa tgtgaatgga 1018921 aatattcatt aagcatgggt catcagaata tttctgattc agtctttagc aatgacagca 1018981 agaatgtctg tgttttttac aagagaaaca atggtgtttc tttttcttct tctcgcaagg 1019041 gtcatggcat tctttctttt tcttgcaatg gtcgtggaaa tctttatcga accactcgtc 1019101 aaagaaccaa aaatcatcga accaatcgtg acaacgacat ttctgttcat gtgaatgacg 1019161 acagcacata gaaatccctc ctcttcccat gctctctaca gcatatgaga gattgatagg 1019221 aaaagattgg acgggtccct cgggaaaaga gtatatttta agtagaaaat aaaaggagga 1019281 atgccctatg acgtccgtac gtaaaacgat ggagctcatt aaagaacttg tatcgatccc 1019341 aagcccgaca ggaaatacat atgaggtgat caattatatt gaaagccttt taaaagaatg 1019401 gaaggtagaa acggttcgga accacaaggg cggcttaatt gcaacgcttc caggacgcga 1019461 cacatcccgg catcgcatgc tgacagcgca cgttgacacc ctcggcgcta tggtgaagga 1019521 aattaaagcg gacggccggc tgaaaatcga cttaatcggc gggttccgct acaactcgat 1019581 tgagggggag tattgccaaa ttgaaaccgc ctcgggaaaa atgtacacag gcacaatctt 1019641 aatgcatcaa acgtctgtgc acgtatacaa agacgcggga aaggctgagc ggaatcaaga 1019701 gaatatggag atccgcctag atgaacctgt tcactgccgg aaagatacgg aggagcttgg 1019761 cattggcgtc ggagactttg tgtcgtttga tccacgtgtc gagatcacat caagcggatt 1019821 tattaaatcg cgccatttgg atgacaaagc aagcgtcgcc ttattgctcc gcttaattca 1019881 tgaaattcaa acagaagaca ttgagctgcc gtatacaacc cattttctta tttccaataa 1019941 tgaagaaatc ggttacggcg ggaattcgaa tattcctcct gaaacagttg aatatttggc 1020001 ggttgatatg ggcgctatcg gtgacgggca ggcgacggat gaatattcag tatcaatctg 1020061 tgtgaaggat gcgagcgggc cgtatcatta tcagctcaga aagcatttag ttcaattagc 1020121 cgagaagcat catattgact ataagcttga tatatatccg tactacgggt ctgatgcgtc 1020181 agcagcgatc aaatccgggc atgatattgt gcatggcctc atagggccgg gaattgacgc 1020241 ttcccatgca tttgaacgca cccataaatc atctcttcgc cataccgcta agcttctgta 1020301 ttactatgta cagtcaccaa tggtataagg gggaggacca atgaagattt ataagctgaa 1020361 aagcacattc ggttgggaag gtgatgacgg gttgggagaa cagctgattc agcagatcct 1020421 tgccggagaa aaaagcgcca cgtgcgcgcc gaaatcattg tattcaaaag atgaattgag 1020481 ggacgtttat caaacagcgg gtcagcttgt taccgtttat gataaacatg acaatccaag 1020541 atgcaatata aaagtaacag atgtctttga aaccaccttt ggtgcgcctg atatgaggtt 1020601 agtcaaagga gagggcaatg gagaccgaat tgaggagttt caagaggatc atcggatggc 1020661 atgggcggaa ctgatcaaaa gcggtgaact ggagctgaat gaggatactg ttttgattac 1020721 agagttgttt gtgcttgtta aagattaaaa aagcctgcgg ggcaagaacc ccgcaggctt 1020781 ttcattaacc agaaatggtt gcgttttgtt ctgttttcga ttgggacata acagtttctg 1020841 ctttcgcagg attaaacatg ccttcccatt tagacatcac aacggcagca agcgcgttac 1020901 cagtcaggtt gacaactgta cgtgccatat ccatgatgcg gtctacgccg gcaataaagg 1020961 caagtccttc agccggaacg ccgatggtgc caagcgttgc aagcaagaca acaaaagaag 1021021 taccaggtac ggcagccatc cctttggatg tcaccattaa gacgagcaca agcgtaattt 1021081 ggtgccaaat cgtcaaatca atgccatata cctgtgctaa aaagagtgcg gcaatagatt 1021141 gatagagaac ggaaccgtct aagttaaacg tgtaaccgat cggaatgaca aatgaaacaa 1021201 tgccttttgg acatccgatt ttctccattt tttccatgat acgcggaaga accgtttcag 1021261 agctggacgt actgaacgcc agtaagattt cgtccttcat gtaagcaagg aacttgaaga 1021321 tgctgatgcc ggcaattttt gcgacaatcc cgaaaataac aattaagaag aaagcaagcg 1021381 cgacataaac caatccgacg agctttccga gagagataag agaaccgagt ccgaatttag 1021441 acacagtcac tccgataaga gcgaaaacgc cgaatggcgc cactttcatc acaaggttta 1021501 caacgtggaa catggcatgg gatacacctt caaaaaaggc taatacaggc ttgcctcttt 1021561 caccgatcgc ggaaataccc aatgcaaata gtactgtaaa gcagatgatg gctagaagat 1021621 ccccttcgac caatgactgg aagaagtttg tcggcacaat atggaggaac gtttccgcca 1021681 ctgatttatt actttgttct ttttcagttt caacatattg actgatgtcc gatttttgag 1021741 cttcgtgtat attaactcct gtacccggat ggaagatgtt tgcaagggct agtccgagaa 1021801 taatggcaaa agtcgtgatg atctcgaagt acagaatcgt tctgaagcct aatttaccga 1021861 cttgctttcc atttcctgca ccggctacac cgatgattaa gctggagaca acaataggaa 1021921 tcactatcat tttgattaag cgtaaaaaga gatccccgat tggctgcagg taagtaggca 1021981 atgctgggtt gccataccaa atgacgccaa caatgacacc tagaataagt ccaacgaata 1022041 tttgtgtggc taatccaaac ttaattcttt tcatagatta cctcccaaaa aacaaagtat 1022101 caacatatat catgaataga catatattta atctcactat tagatcaaat tataatagat 1022161 aagaaatcaa ttcgtctata gtaaattata tttcgaaaat aaagaatatt caatgacatt 1022221 atgataatca ccagaattat ctaaaaacag gtgagctttg acctaacctg actattattt 1022281 caaaattaag agatatgtga aaaaataaga aaatcccacg cgtaaggcgc gggattttcg 1022341 ctcattacaa atcgtttact tttatacagt cattgcagat attaccataa cactcatgct 1022401 gctcttctat cttttttccg cattccgcac actttttcga aggcaggttt ctaaaaaatt 1022461 ctgtgatttt ccccagcata accaatccct ctttcccctt tgtagtgatt tcattgtaat 1022521 ataacagatt acaaaaatca ataactgttt tgatacaatg tttaaaacat gcttttttca 1022581 agaaaaatgg gtatattgaa ggaggaccaa tttttttgaa aagataggag gacattatga 1022641 aagttacagt tatcggatgc tatggcggtt ttccggccgc aaatgaagcg acgtcaggct 1022701 atttgtttca gtcaggtgat tactctctgc ttgttgattg cggcagtgcc gtattgtcta 1022761 agctgttcgg atatgtgccg gcggaaaagc tggatgcggt cgttctgtct cattatcacc 1022821 atgaccatat cgctgatatc ggaccgctgc aatttgccaa gcaagtcggt tcgtttctcg 1022881 gcaaaggaga gcatacgctt ccgatttacg gacatgatgc tgatatagaa cagtttcaaa 1022941 agcttacata taaaacacat acaaaaggga tcgcctatca gccggatcag ccgctgactg 1023001 ccggtccgtt tacgatcacc tttttaaaaa cgattcaccc ggtgacgtgc tatgccatgc 1023061 ggattactga cggcagccac actgtcgttt atactgctga ttccagctat caggattcat 1023121 ttataccgtt ttcgaaagat gctgatttat tgatctcaga atgcaatttt tatgccgatc 1023181 aagacggaac aagtgcaggc catatgaaca gcctggaagc tgggcgcatt gcaaaagaag 1023241 ccggagcggg agaactgctg ctgacacatt tgccgcattt tggcgtgcat gacaaccttc 1023301 gcaaagaagc gaaaaccgtt tttaacggag aagtgaatat tgcgaaatca ggttttgtgt 1023361 gggaaggata aaggaggagc accatgttat ttatagacaa tcaaaatatc aatgatccgc 1023421 ggatcaatct tgctatcgag gagtactgtg taaagcattt agaccctgaa cagcaatatt 1023481 tgctctttta tgtgaatcaa ccgtctatta tcattgggaa aaaccaaaat acaatagaag 1023541 aaatcaatac aaaatatgtt gaggaaaacg ggattatcgt cgtccgccgt ttatcaggcg 1023601 ggggcgctgt gtaccatgat ctggggaact tgaacttcag ctttattacc aaggatgacg 1023661 gggacagctt tcataacttt aaaaaattca ctgagccagt gattcaggcg ttacatcagc 1023721 ttggggttga agccgaatta agcggccgga acgacattgt agtagatggc cggaaaatat 1023781 ccggaaacgc tcagtttgca acgaaaggcc gtattttcag ccacggcacc ctcatgtttg 1023841 attcagccat tgatcatgtt gtatcagcat taaaggtgaa aaaggataaa attgaatcaa 1023901 aaggcatcaa atcgatcaga agccgagtgg caaacatcag tgagtttctc gatgataaaa 1023961 tgaccaccga agaattccgc agccatttgc ttcgccatat ttttaacaca aacgacgttg 1024021 gaaacgtgcc ggagtataag ctgacggaaa aagattggga gaccattcat caaatttcga 1024081 aagagcgcta tcagaattgg gattggaact acggccgctc accaaaattt aaccttaatc 1024141 attcgaagcg ttatccggtt ggatcgatcg atttgcacct ggaagtcaag aaaggcaaaa 1024201 tcgaggactg caaaatcttc ggagatttct tcggtgtcgg tgatgtatct gaaattgaaa 1024261 acctgctggt cggaaaacaa tacgaacgca gcgtcatcgc tgatgtgctc gaaggtgtga 1024321 atctcaagca ttactttggg aacattacga aagaggattt ccttgatctg atttactaag 1024381 gcaaaacaca tcgtttgaaa gagcggttgt gtttttgaaa taatggaggc aggagggatt 1024441 cacatgaaag tgtttttaat cggagcgaac ggacaaatcg ggcaaagact cgtctcttta 1024501 ttccaagata atcctgatca ttccatcaga gcgatggtca gaaaagaaga acagaaagcg 1024561 tctcttgaag ctgccggtgc agaagctgtg cttgcgaatc tggagggcag cccggaagaa 1024621 atcgccgctg cggcaaaagg ttgtgacgcg atcattttca cagccggttc cggcggcagc 1024681 acaggctatg ataaaacgct gctggtggat cttgatggag cggcaaaagc cattgaagct 1024741 gcggccattg ccggaatcaa acggtttatt atggtcagcg ccctgcaagc ccataaccgt 1024801 gaaaattgga atgaggcact caagccttat tatgtggcca agcattatgc tgataaaatt 1024861 ctggaagcga gcggtttaac ctatacgatt atccgtccgg gaggccttcg caatgagcct 1024921 ggaacgggaa ctgtttcagc agcgaaggat ctggagcggg gatttatttc ccgtgatgac 1024981 gttgcaaaaa cggtcattgc ctctttagat gagaagaata cggaaaatcg ggcctttgat 1025041 ctgacagaag gagatacgcc gattgccgaa gcattgaaga aactatgaca gtactgacac 1025101 tcagggcttt ttgctcttga gtgttttttt ctgtttctct ataatggaga agaaagcttg 1025161 gcttcaataa tgaatgacta ttcattcact taaggggtgg gagaatgaat cttgtttcaa 1025221 aattggaaga aacagcatct gagaagcccg acagcatcgc atgcaggttt aaagatcaca 1025281 tgatgacgta tcaagagctg aatgaatata ttcagcgatt tgcggacggc cttcaggaag 1025341 ccggtatgga gaaaggggac catttagctt tgctgcttgg caattcgcct gattttatca 1025401 tcgcgttttt tggcgcttta aaagctggga tcgtagttgt tcccatcaat ccgttgtaca 1025461 cgccgacaga aattggttat atgctgacaa atggcgatgt aaaggcaatc gtgggcgtta 1025521 gccagctttt gccgctttat gagagcatgc atgaatcgct gccaaaggtt gagctcgtca 1025581 ttttatgcca gacgggggag gccgagccgg aagctgcgga cccagaggtc aggatgaaaa 1025641 tgacaacgtt tgcaaaaata ttgcggccga catctgccgc taaacaaaac caagaacctg 1025701 tacctgatga taccgcggtt attttatata cgtcaggaac gactggaaaa ccgaaaggcg 1025761 cgatgctgac acatcagaat ttgtacagca atgccaacga tgtcgcaggc tatttgggaa 1025821 tggatgagag ggacaatgtg gtctgcgctc ttcccatgtt tcacgtgttt tgtttaaccg 1025881 tctgtatgaa tgcaccgctg atgagcggcg caactgtatt gattgagcct caattcagtc 1025941 cggcatctgt ttttaagctt gttaagcagc agcaggcgac catttttgcc ggtgtgccta 1026001 caatgtataa ctacttgttt cagcatgaaa acggaaagaa agatgatttt tcttcgatcc 1026061 ggctgtgcat ttcgggaggc gcgtccatgc cagtcgcgtt gctgacggcg tttgaagaaa 1026121 aattcggtgt taccattttg gaaggctacg ggctctcgga agcatcaccc gtcacgtgct 1026181 ttaacccgtt tgacaggggc agaaagccgg gctccatcgg gacaagtatc ttacatgtcg 1026241 aaaacaaggt cgtagatccg ctcggacgcg agctgcccgc tcaccaggtc ggcgaattga 1026301 tcgtgaaagg ccccaatgtg atgaagggct attataaaat gccgatggaa acagagcatg 1026361 cattaaaaga cgggtggctt tatacggggg acttggcaag acgggatgag gacggctatt 1026421 tttacattgt tgaccggaaa aaagacatga tcattgtagg aggatacaat gtgtatccgc 1026481 gggaggtgga ggaggtgctg tacagccatc cggacgtcaa ggaggcggtt gtcatcggcg 1026541 tgccggaccc ccaaagcggg gaagcggtaa agggatatgt ggtgccgaaa cgctctgggg 1026601 taacagagga ggacatcatg cagcactgcg aaaagcatct ggcaaaatac aagcggcctg 1026661 ccgccattac gtttcttgac gatattccga aaaatgcgac ggggaaaatg ctcagacggg 1026721 cactgagaga tattttgccc caataaaatg aaaaagcgaa gcggttagct tcgctttttc 1026781 attttcaatc ctttgcttct tttttaataa tatttagcag cgcctttgta tcatttttgc 1026841 ttaatttgta gtatgtgcca tccttcaaaa aaacggcttg ctggctgccg tcaatccata 1026901 gtctgaatga gtcataccgg tctttatgaa acttgattgt cccttcgtaa tcaggggctg 1026961 atgttttttc tgtcttcacc tgttttccct gattcataat atccagcata tctttgacgt 1027021 gctgtctttt ttcaatctcg atatcttcct ggccgcttga agacagtgtg atcaaatccg 1027081 cgtctaccga ttgatacaca tcgcctgatc ggctgtaaag ataaaaaaat gcgataaaca 1027141 caagaccgat taccacgatg gctgccacta tttttttcat ttgcatcact ccaaacattg 1027201 ttagttttcc cagcgatcgg ggtttccatg cttaaaaggg tggaaaagtg cggaacacag 1027261 cttggttcta agaatttgaa tttatgatta caatagaagt aacgggttga tgtgaggagt 1027321 gaggcgttat gcgcaagtgg attgcggcag caggacttgc ttacgtgctg tacgggctgt 1027381 ttttttattg gtattttttc ctgtcgggtg attccgcaat accggaagcc gtgaaaggga 1027441 cgcaggctga tccggcttct ttcatgaagc cgtctgagtt ggcagtggcc gagcagtatt 1027501 cgaatgtcaa gaatttttta ttttttatcg gggtaccact tgattggttt ctgttttttg 1027561 ttctgcttgt cagcggtgtt tcaaagaaaa tcaagaaatg gatcgaagcg gccgtgcctt 1027621 ttcggttttt gcagaccgtt ggttttgtgt ttgtgctttc gctgattaca acattggtga 1027681 cgctgccttt agattggata ggctatcaag tatcgcttga ctataacatt tccacacaga 1027741 caacggccag ctgggctaag gatcaggtta tcagcttttg gatcagcttt ccaatcttta 1027801 cgctttgcgt tctcgttttt tattggctga tcaaaaggca tgaaaaaaaa tggtggttat 1027861 acgcctggct gttaacagtg ccgttttcgc tgtttctgtt ttttattcag ccggtcatta 1027921 tcgatccttt atacaatgat ttttatccgc tgaaaaacaa agagcttgaa agcaaaattt 1027981 tagagctggc agatgaagcc aatattccgg ctgaccatgt atatgaagtg aacatgtcag 1028041 aaaaaacaaa tgcgctgaat gcctatgtta caggaattgg ggccaataaa cggattgtat 1028101 tgtgggatac gacgctgaac aaacttgacg attcagaaat tctgtttatt atgggccacg 1028161 aaatgggcca ttatgtcatg aagcacgttt acatcggtct ggctggctat ttgctcgtgt 1028221 cgctcgccgg attttatgtc attgataagc tttacaagcg gacggttcgc ctaacccgca 1028281 gcatgtttca tttagaaggg cggcatgatc ttgcggcact tccgctgtta ttgcttttgt 1028341 tttctgtttt gagctttgcg gttacgcctt tttctaatgc tgtctcgcgt tatcaggaga 1028401 ataaggctga ccagtatggg atcgagttga cagagaacag agaagccgct gttaaaacgt 1028461 ttcaggattt ggccgtgacg gggctgagcc aggttgatcc tccggtgctt gtgaagattt 1028521 tcagaggcag ccatccgtcg atcatggaac ggattcaaca tgcggagaaa gaagagaatg 1028581 cgccggaaca tcaggatgct gacaaataaa aagaagcagg tatggaggaa cctgcttctt 1028641 tttactatta ttgtgcagct gcttgtacgt tgattaaccc ttttccatag tagaaagagt 1028701 ttccaagata tgttgcagtg ctttctaaac gatcacggac ttgcgcgttt gtccaagtcg 1028761 ggtgcttaga aagaattaac gctgctgctc cggcaacgtg aggagtcgcc atggacgttc 1028821 cgttataagc gccgtaagtg cctccaggaa gtgtgctttg gatggacacg ccaggagcca 1028881 tcacatcaag ctcagaacct gcgctggaga atgaagctct ttggttgctg ctgtttaccg 1028941 cacctactgc aatagtagaa ggatattttg cagggtagcc gactgtgctt gtgcttccgg 1029001 atgaaccttc gtttccggct gcggcagcaa cgacgatacc gctggaaacg gctttgtcaa 1029061 cgactgtttt cagcgctgta gaaccagtag gtccgccaag gctcatgttg ataacatcca 1029121 tattgttgga aatggcccac tcaatgccgt taataatcca gctatattgg ccgcttcctg 1029181 ttgaatcaag cacttttact gcatataatg atgcgcttgg cgctacgccc agaacaccga 1029241 ttgagttatt aagagcggca atcgtaccgg ctacatgcgt accgtgagaa ctgccgtcct 1029301 ggtatgggtt tgtttcagaa ggtacgaagc ttgctccgcc tctgacgttt aagtcaggat 1029361 gagaagagtc aattccgctg tcgataacag ctacttttac gttagagcct gtgtagcctt 1029421 gagagtgaag agccggcgct ttaatttgag aaatgccata aggaacagat tgcgcatatt 1029481 catgtgcaat atgatcttct tccacatatg caacgctcgg atcttttttc aattctttta 1029541 cagctttttc atccaatgtt gctgcggccg cgttaacata cttaaattgc ttttgaacct 1029601 ttccgccttt ttcagaaata acatcctttt tcttggcgga actcatggca ctcattgtct 1029661 gtttaaatcc gacaatgtat ttcttttctg tactgctttt tccggcagcc tgcgcagaca 1029721 tgttgctgaa cgccatcgta aagattaacg ttaacgcaaa caacaagctg atccacaatt 1029781 ttttgcttct cactctttac cctctccttt taaaaaaatt cagagtagac ttacttaaaa 1029841 gactattctg tgaatttatt gtaatagatg gaataatatt ttagtagacc catttttttg 1029901 agatgatttt atctctattt aggtatatca tctctcgcta tttccgtaga gactcgaaat 1029961 aactattttc atacagaaaa gaacgaaaat agacatgagt aaatgttcat tatgctgaaa 1030021 tgtcatgctt ttttaggtta aatgctcctg agtcccggca aattcctgtc gaaaaaattc 1030081 gttcaaatga cctgcgtgtg cttccgtgag aacaatggat attatcgtga tattttttca 1030141 aagcatgatg ataaaagtat tctgaaaaat aaactttaca gaaaagggat agaatgaaaa 1030201 aattattgag agggaggaag aaataagatg aacattcgcc aagcaaagac atcagatgcg 1030261 gccgccattg cgccgctgtt taaccaatat cgggaatttt atagacaggc atccgatttg 1030321 caaggggcag aggctttttt gaaagctcgt ttggaaaatc acgagtctgt tattttgata 1030381 gcagaagaaa atggagaatt cataggcttt acccagctct atccaacgtt ttcttctgtg 1030441 tcaatgaaaa ggatatacat attaaatgac ttatttgtcg ttcctcatgc gcgtacaaag 1030501 ggagccggcg gccggctgct ttctgccgca aaggattatg cagggcaaaa cggggcaaaa 1030561 tgtttaacac ttcagactga gcaccacaac cggaaggcaa gaagcttgta tgagcaaaac 1030621 ggctatgaag aggataccgg atttgtccat tattgtctca atgtgccggc gaagtgaaaa 1030681 tggcggcttg atgatttggt tttttgaacg ttcttcggtt acgatataaa tgaaaaggag 1030741 tgtgccgaat gtcaacgtta tttcaagcct tgcaggcaga aaaaaatgcc gatgatgttt 1030801 cagtccatgt gaaaaccata tcaacagagg atttgccgaa ggatggtgtc ctgattaaag 1030861 ttgcttattc cggcattaat tacaaagatg gtctggccgg aaaagcagga ggcaatatcg 1030921 tcagagagta tccgcttatt ttaggcattg atgctgcggg tacggtcgtc tcttccaatg 1030981 atccgcgttt tgcggagggg gatgaggtga tcgcgacaag ctatgagctc ggtgtctcac 1031041 gtgatggcgg attaagtgaa tacgcttcgg tgcctggtga ctggctggtg cctttgccac 1031101 agaatctttc gttaaaagaa gcgatggtgt acggaacggc gggatttact gcggcgttat 1031161 cagtgcatcg gcttgaacag aacggtctgt ctccggaaaa aggcagcgtg ctagtcacag 1031221 gagcaaccgg cggtgtcggc ggaattgcgg tatcgatgct gaacaagcgg ggttatgatg 1031281 tggtggcaag taccggaaac cgggaggcgg ctgattattt gaaacagctt ggtgcaagcg 1031341 aagtaatcag cagggaagat gtctatgacg gaacgcttaa ggcgctgtcc aagcagcaat 1031401 ggcagggagc ggttgatcca gtcggcggaa aacagcttgc ctcgctttta agcaaaattc 1031461 aatacggcgg atctgtcgca gtgagcggct taaccggcgg aggagaagtt ccggcaaccg 1031521 tgtatccttt tattcttcgc ggagtaagcc tgctcggaat cgattcagta tattgtccga 1031581 tggacgtcag agccgctgtt tgggagcgca tgtcttctga tctcaagcct gatcagctgc 1031641 tgaccatcgt ggacagggaa gtatcattgg aagaaacgcc gggtgcgtta aaagatattt 1031701 tgcaaaatcg cattcaagga agagtgattg tgaagcttta acaggatcag cttgcagaga 1031761 atgttatttt tctgcaagct tttttgtgga caggatgatc agctgctgaa ctgctgtgtc 1031821 gcgaaacaag attttcctgt aagccgaact ttctcttctc attttaaaaa taattggtga 1031881 taatgattct cattccgtgt tatactactc ttggacatct taaccataga aactaccaac 1031941 aggagagact ggaacatatg aaaaaaacac tgattattct tacagtttta cttctttctg 1032001 tcttaacggc tgcttgctcg tcttcaagcg gcaatcaaaa cagtaaagaa cataaagtgg 1032061 cggtaacaca tgatttaggg aagacaaatg tgcctgagca tccgaagcgg gttgttgttc 1032121 ttgagctagg ttttattgat acactgcttg atctcggcat tacgcctgtc ggggttgccg 1032181 atgacaacaa agcgaagcag ctgatcaaca aggatgtgct gaagaaaatt gacggctaca 1032241 catctgtcgg cactcgctca cagccaagca tggaaaaaat cgcttcatta aaacccgatt 1032301 taattattgc tgacacgacc cggcataaga aggtgtacga tcagctgaaa aaaatagcgc 1032361 cgacgattgc acttaataat ttaaatgctg attatcagga tacaattgac gcttcgctta 1032421 cgattgcaaa agcagtcggc aaggagaagg aaatggagaa aaagctgacg gcgcatgaag 1032481 aaaagcttag cgagacaaag cagaaaatca gcgcgaacag ccagtccgtg cttttgatcg 1032541 gaaatacaaa tgataccatt atggccaggg atgaaaactt ctttacatcg agacttttaa 1032601 cacaggtcgg ctaccgatat gcaatcagta cgtcaggcaa tagcgattca agcaatggcg 1032661 gcgactctgt gaatatgaaa atgacactgg agcagctgct gaaaacagat ccggatgtga 1032721 tcatcctgat gacaggaaaa acagatgacc tcgacgccga cggtaaacgc ccgatcgaaa 1032781 agaatgtcct ttggaaaaaa ctgaaggcag tgaaaaacgg gcatgtatac cacgtggatc 1032841 gtgcggtgtg gtctctgcgc cgcagtgtag acggggcgaa tgccattttg gacgagcttc 1032901 aaaaagagat gccggctgct aagaaataaa agaaaagaca ggcaaacgcc tgtctttttc 1032961 ttatttgata aagccggata agtggctgtt gatattatag tcttttatcc gccatttttc 1033021 ttctgcaaat tcaatgttgc tgaggcaggc gttgacgaga cgggtgcttt gaagctccgg 1033081 gtcaccgccg gatatttctg tcagcagggc gtgaattgcc gcaccgtgcg ccacgatcag 1033141 caccttcttg tttggatacg cctgattcac ttttgccaaa ccgcccatca gcctgtcagt 1033201 gagttcttct aaggtttcca tattcggata gatgttatct ggatagcgct ttgtccgttc 1033261 ctccagcggc atgccctccg cgtcgccgta atcgcgttcc ttaaaatcat ccatctcgac 1033321 tatcggaaga tgcagatatt cattaataat ttccgcggtt cttttcgctc ttttcagcgg 1033381 gctcgtcaca ataatatccc aagaaaagtc ctttacatat tctccggttt ctcttgcttg 1033441 gcgttcacct gttgcgttta gcgggatatc ggttttgcct tggcattttt gctgcaggtt 1033501 ccaatcggtt tctccatgtc ttactaaaca aacggctgtc ataaaatccc cttcctgact 1033561 ttattcatat cgctattata ctaaatcgaa agcgtgtgtc ctatgaaaaa gcctatgcaa 1033621 gaacttcaaa taataaagcc agtccgattc cgccgccgct tccgatggct gcaacagcat 1033681 attgacagtc tggccgtctt ttcgcttcat aaaacaatct ggttaccaga gctgcacctg 1033741 atgcaccgta cggatggcca agagctaagg cgccgccgcg cacattgatt tttgaaaagg 1033801 gaatgccgag ttcttgcgag cagacacaaa ttttgacggc aaaggcttca ttgatttcaa 1033861 ataaatcgat atcatcaggt gttacatcgt gtgtatgtaa gagctgacga atcgcgacaa 1033921 ccggtgccgc gggcggaaag ttggggtgaa tgccgctgac agcgctgccg ataaaccgaa 1033981 gcacaggctt aagtcccagg gctgctgctt tttcttcttc cattaccaaa agagcggctg 1034041 ctccgtctgc tatgccactg ctgttggctg ctgtgactgt tccggagctg gtgtcgaaaa 1034101 ccggctttgc acggggaata atcgcttcta ttggccgcgt tttcaaaaat gcttcgtccg 1034161 tctccaattc cccgagagca acaacttctt cacggtaaaa tccttcatca tgcgcgttcc 1034221 tgctgcgttg atggctgaga agcgcgtact catcctgcat gcttctgctg atggaatagc 1034281 gtgcagccgt atattctgcc gcaatgccca tgtctggatc gccgatcgca tctggagaaa 1034341 agcgagcccg ttctgaaaaa ggggattggc tgctgctttc tgagccgccc gcgatataca 1034401 tcgtgccggc tcccgcttga ataaggctgc aggcatagcg cacagcttca aggccggagc 1034461 cgcactgtct gtcaattgtc attccgggaa ccgataaagg cagtccggct tgaagggctg 1034521 acagtctggc caggttgccg cctctgccag tagcgtttcc gagaatgacc tcgtcaactt 1034581 gatcctctag ctttcggctg agacagcgga tgatgggagc cgccaaatcc tccggcagga 1034641 agggcttcag cagtccgttt tgatttccaa agatcgttcg ttttgcatca acaataaccg 1034701 cattcattta tactgtacac tctcttccag ccattttttc actctggaac gggcaatttt 1034761 tccgctgctc gtttccggca agctgtctgc aaacacccat tttttcggaa ttttatagga 1034821 ggctaatttc tgtttacacc aggctttcag tgttctggca ttagcgtttc caagaatgac 1034881 agctacagcg atttctcccc aatactcgtc gggaatgcca acgacagccg cgctttcaac 1034941 ctctgggcag gcgagaagca cacgttcaat ttcttctggg aaaatattta atcctccgta 1035001 cacgatcatc ccgttttctc ttcctgatat gtatagaaag ccctcttcat caacgtagcc 1035061 catatcatct actgtcatcc attcatctgg tgtgctgccg ttcacatagc cggaaaacct 1035121 catcgggctt ttgacaaata tttttccgat ttctcctggc tggcagcgtt ctcctccagc 1035181 gttgcggatt tcgatccgga cattatgaaa agggcggccc gctgaatgcg gcttccgttt 1035241 gctgtcttcc ggtgaagaaa acgtcacaaa actaagctct gatgtgccgt aaaaatcgta 1035301 cagcttgaga tgaggccatg cagcggcaag cttcttcttg gattctgccg gccagtctgc 1035361 gccggatgaa atgattttga cgggactgtc gggaaaaccc tcaatccttg cgagggcgtc 1035421 tgtcatcgtc ggtacggtat agagaacact gatggattca cggcacagcc attccttcgc 1035481 tttggcagga gaaaactttt tcagcaaaca aacggttcct ccgagaaaca aagtgctgac 1035541 agccccatat aggaagtgag aggacattaa cgctccggga atcagaacct tatcatctga 1035601 tgaaatcgaa aaatctgttt ctgtacaggt aaagctctcc atccatgagc ggtgagatcg 1035661 cgtaaaggcc ttcggttttc ctgtcgagcc cgacgtaaat cccatataaa aagggtgctc 1035721 cggatcaatg gtaggcaagg gatcagcggc tgcctcagaa atatctgcca tacagttatc 1035781 cagcaataca acaggtgtct ggctatctgt cagtttgttt ttgaaaaagg ctaaagtaac 1035841 cacaagatcc gcattgctta tggacagccg ctccttacat tcagccgggc tccagcgtgt 1035901 gtcgatggga atggccgtac atccagccgc tgcggctccg gcaaacagct gtaaaaacgc 1035961 gagactattt gggagcagga tcgccacacg attcggcatg ctcggctgtg accgcagcca 1036021 atttgcggtt tgagagacaa gccgatccca atcatggtac gtgatttgct ccgattcagt 1036081 ctggatcgct acacggccgg gcgatgtttc ggcagtagat gaataggtat gagtaattgt 1036141 catgtattgt catcctcctt ttgtaaacat cgtatcagaa agagacaagg cttgagtgat 1036201 ttttatcgcc agaaatgcag atacagccgc ttttatcaaa tcaccaggca catatgcaag 1036261 gctcatgaag gcggcctgtg acaaatcaat atgcatgata aaagcttgta ccggtatacc 1036321 aagcagataa ataaagatga tgccgaatac gatatgagtg aaaaagagac gcaatactgt 1036381 caccttccgc agcctgttag cggctaaact gatcagccat gaagcgaggg gataagcaat 1036441 caaaaagcct gcgctcggtc cgaaaaacac accaaaaccg cctcgtccgc cgggcaacag 1036501 cggcgctccg aaggcgacga gcagcaaaaa gacaagctgg cttaagaaag cagactttgg 1036561 cctgagaatg ctgcctgcca acatgacacc aagcgtttgc aatgtaatcg gaacgggtgt 1036621 aaaggataag aagagagggg gcataaagcc gagcactgcc atcagcgcgg tgaaaatcgc 1036681 aatatgcatc atgtcgatta atttcagcat gtgaaatcct ccaaaaagta atcaaatatg 1036741 gttatacaat aaatgcaggt aattattatg tcaactgatt tttaatttaa gtttacataa 1036801 tgaacgcaaa aaaaccggcc gtatggcaga ccggtttttg atggttattc ttctgtcagg 1036861 atgacaagcg aatcaacgga agcggccaca tgggaaacgg cgcggctgac ttcctgaagc 1036921 cctccaagaa aggcttgcag atcgacgtcg attttgcctg attgctcttt gctgattttc 1036981 atgctgtgga cgatttcatc gaataagcgg ttaatttgcg tcattttttc tttactttcg 1037041 ctgactagct cattcacgtc tttgatatgc ttggatacaa tgttgatttg tgtattcgta 1037101 ttgttcacaa gctcagaaac agtagagacg gtttttttcg tatcctcaga aagcttccgc 1037161 acttcatttg ccacgacagc aaagcctttg ccgtgttctc cggcgcgggc ggattcaata 1037221 gatgcattga gcgagagaag gtttgtttgt tcagctatgc ctgtgacgat gccgaagatt 1037281 ttttcaattt gctgcgcgat ttcatccagc ttgaccattt ctttttcgat ttggacaagg 1037341 cttgtgtcaa ttttgttcat ctgtttttgc tggacttcta gctctttttt tccgccgatc 1037401 gacttttctt caacagtgct ggatgttaca gtgccggctt tggatgcttg agaaatgcct 1037461 tcagatttgt ccacaagctc ttgaactgat ctgcttgttt ctgaaaacag attggcaatc 1037521 gatccagagg tttcttgaat tttctgatga agaaggtttt tcttttcttc ttgttcatca 1037581 cgggtctggt tgtactcgct ttgaaacgct tcaaggacaa gctgctgttc taagttcaag 1037641 atttttgttg ttgctttaat ggcttttagc agttcttgct gatttgtaat ggacgcttca 1037701 taaatgtcaa tcattgacaa aaggagctct tgaaacgcac ccatatacca ttttggcaaa 1037761 aggccgattc ttaaatggat ggaggcgatt cggttacgct tttcaataaa ttcatcatcg 1037821 ataacgcctg caaacatttc ctgaatatgc cgttttaacg tttgttttaa gcggtcaact 1037881 gagctgtgat cattaatgat atccatcaat gagctttcat ggtcaaggtt tttataaaac 1037941 gcatcgacga tatttacgat attttcttga atgagtggct gaagctgctc taacacataa 1038001 agctcagcat ctcccaacct gaccattttg agctgttttt tgacatctgc atgtttgttt 1038061 gtgagctgaa tgcggttttt ttgttgtccg tttgaatctg aaaagtaagc tgtttcttgt 1038121 tttctgtctt ttttaaataa caatacaatg atcccccttg ggaaaaatat aatttttact 1038181 ttttggcttt ttaagccttt ttctttttta tcggccaagg gaaacatgaa tgaagctgca 1038241 gatgaaaaat atttgaaaaa acgttcatta aaatgaacgg tttaatcgag atctatttgt 1038301 tttaatggtt taatggccgg accctctaca acttcgccag atggcttaaa gcgtgatccg 1038361 tggcacggac aatcccacgt atgctcactg tcgttccact cgacctcgca gcctaaatgg 1038421 gtacaagtcg tatcaacgag atggaggcag cctgtctcat cacgaaatgc tcccgctcgc 1038481 ctgccgttta tggtgacggc tttcccttct cctggcgaaa tgtcttcaaa ttggacatca 1038541 ggcttttcaa gctttccttt tatcaaatgc ttggcgacat ctgcattgta ggaaatcact 1038601 ttctgcaacc cgggattcag atggaaacgg gacggcgtga aaatgctttc gtatgggttt 1038661 tcttttttct ccacaaggtc tgacaataaa gtggctgcga ctgctgagga cgtcatgccc 1038721 cattttttga acccggtcgc tactagaata ttgtcctcat tttccgacat cggcccgata 1038781 aacgggattt tgtcgatcgt cactagatct tgggtggacc aataatatgg aatgctttcg 1038841 atgccgatgg tgctttcggc cagttgtctc agtgtttcat aatgtgtaga catggctttt 1038901 ccctggcctg ttttatggct tactccgctg aagagaatca gcttttcacc gtttacaacc 1038961 gtatagcgga gcgccactga cggctgatcg atactcaaat acatgccctc gggatactcg 1039021 atcttcggct tgatggcaag gacataagat ctgtcggagt acattctcgc agcatataat 1039081 ccgcctccgt cataaaaagg gaagtgggaa cagcatatga taaagcggct cttaatggcg 1039141 tgccggcttt ttgttaccac ttcgggcctt tcgccttttt tgatatcaag cgcaacggtc 1039201 tcttcataaa ttcggccgcc tttttgaaca atttgctcca gaagcgcttt taagtattga 1039261 agcggatgaa attgagcttg attcttcatg acaagcgcca gcttagaacc taagggaatt 1039321 ggaagatcct tgataaggtc tctttcaatt ccgagctttg tgtatgcctc atgctcggtg 1039381 tggatttttt gaacagcgtt ttcatttgcc gtataaagat atgcgtcttg ctcgatccat 1039441 tcacaatcaa tttgatgttc atccacaatg ccttttatgt aatcaattgc gttttggttt 1039501 gcttcataat aaagcctcgc atggtttaat ccgaaatggc ggataaattc gtcgtatatc 1039561 atgtcatgct gtgcggtaac tttagcagtt gtatgcgcag tggttccgtt aagaacctga 1039621 tttgcttcaa tcaaaacgac acggaagcct ctcttcgtaa gttcatatgc cgttgtgatt 1039681 cccgtaatcc cgcctccgat aatggtgacg tcacattcag tgtcctcttg aagcgcagga 1039741 aaagaaggca ggtcagttga tgttttccag tatgtttcag gtgcttcctt tgcaaaatgt 1039801 tgattagcca agccgttata cctccaatca gatttattct taatttttcc atattctatc 1039861 ttttcataca taggaagcag gcattgttca taacataata aggttgaaaa ggagtgattt 1039921 cattggcgaa tcaaaaaaag aaaacattac cgcctcagca ccagaaccag cagcctggtt 1039981 ttgaatatct gatggacccg cgtccggttt ttgataagcc gaagaaagcg aaaaaattag 1040041 agggcaaaac cgctattatt actggaggag acagcgggat tggacgcgct gtctcggtgt 1040101 tattcgcaaa agaaggggct aatgtggtca ttgtgtattt gaatgaacat caggacgccg 1040161 aggaaacaaa gcagtatgta gaaaaggaag gggtaaaatg cctgctgatt gcaggagatg 1040221 tcggggatga agcgttttgc aatgatgtgg tcgggcaggc aagccaagtg tttccatcca 1040281 ttgatatatt ggttaacaat gcagctgagc agcatgtcca gcccagcatt gaaaaaatca 1040341 ccagccacca gctgatcaga accttccaaa caaacatttt ttccatgttt tacttaacaa 1040401 aggcagtgct gcctcattta aaaaaaggga gctctattat taataccgct tcaattaccg 1040461 cctataaagg caataaaacg ctgatcgatt attcagcgac aaaaggcgcg atcgttacgt 1040521 ttacaaggtc cctttcccag tcgcttgttc agcagggcat acgggtcaat gcagtggcac 1040581 cgggtcccat ttggacaccg cttatcccgg ccagctttgc cgcaaaagac gtggaagtgt 1040641 ttggttcaga cgtgccgatg gaacgcccgg ggcagccggt cgaagtggcg ccaagctatc 1040701 tataccttgc cagcgacgat tccacatacg tcacagggca gacgattcac gtcaatggcg 1040761 gaacaattgt gaacggataa taaaaagcca atccttgaag gattggctta ttcgctctgc 1040821 ttgagcgctg catattcttt agagagcgta agaaacgcat ctttatcttt ttcgtccaag 1040881 gctttgttaa tttggtccgt cagcatggca agccgacggt tatacaagga ttcatcgagc 1040941 accatttgaa tgtaaatatc cgtcattgtg acatcgaatt cttttgtttt ttgcgtgttg 1041001 cgggacttca tgagctcagt gtacgatttt ttctctttca taaagaatcc ccccaatgcc 1041061 ttttttatag tatatggata acggtcgaaa aaatcaataa atttttataa tttttagaca 1041121 actaatactt ggcaatctat cgacatatcc tgcaaaatgc cgtaaaccgg caagtcttat 1041181 gaaagtaaaa tcggtttatt actagtcatt tagtaccatt aaatatcatt aaaagatgat 1041241 tttatcttaa atgttaaaaa aacctgtcgt tttacaaaaa cagatgatag attattagta 1041301 taaattttgc agaaaaagga tggaggccat aatatgagtc agaaaacaga cgcaccttta 1041361 gaatcgtatg aagtgaacgg cgcaacaatt gccgtgctgc cagaagaaat agacggcaaa 1041421 atctgttcca aaattattga aaaagattgc gtgttttatg taaacatgaa gccgctgcaa 1041481 attgtcgaca gaagctgccg attttttgga tcaagctatg cgggaagaaa agcaggaact 1041541 tatgaagtga caaaaatttc acacaagccg ccgatcatgg tggacccttc gaaccaaatc 1041601 tttttattcc ctacactttc ttcgacaaga ccccaatgcg gctggatttc ccatgtgcat 1041661 gtaaaagaat tcaaagcgac tgaattcgac gatacggaag tgacgttttc caatgggaaa 1041721 acgatggagc tgccgatctc ttataattcg ttcgagaacc aggtataccg aacagcgtgg 1041781 ctcagaacca aattccaaga cagaatcgac caccgcgtgc cgaaaagaca ggaatttatg 1041841 ctgtacccga aagaagagcg gacgaagatg atttatgatt ttattttgcg tgagctcggg 1041901 gaacggtatt agaaaaatag gaaggagctg accgaacagg gcagctcctt tcataaagct 1041961 atgccgtcgg aattcctccg gtgatgccat atacctgaga tgtcacatag cttgaattct 1042021 ctgaagctag aaatacataa acatcggcca attccactgg ctgcccagcg cgatttaatg 1042081 gagctggcgg cgtgccttgt ccgaatttcg ggatgttttc cgtcggctgt ccgccggaaa 1042141 tttgcagcgg tgtccaaatt ggtccgggcg caactgaatt tactctgatg cctttggaag 1042201 caagctgttt tcccagtccg acggtaaagc cgataatggc gtttttcgtt gctgcgtaat 1042261 ctaacagcat cgggcttgga ttatagcctt caactgaggt agttgtgata attgaagctc 1042321 cctccggcaa atacggaagc gccgctttta caacccagta aagggaaaag acgttcactt 1042381 caaatgtttt atagatttgt tcagtaggca gatcttcgat gttttcgacc gcttgctgtt 1042441 tgcctgcaac gagcgctagc acatcaagtc cgccgagttc gtgatgcgac tgtttgacta 1042501 gatcttggca aaaggattcg tcgctcaagt ctccggggat cagcactgct tttcggcctt 1042561 ctgcttcaat cagctctttt acctcttcag catctggctg ttcctcgggc aagtagttaa 1042621 tagccacatc ggcaccttct ctggcgtaag caattgcggc agcgcggccg ataccggaat 1042681 cgccgcccgt gacaagcgct tttcgacccg ttagtttacc tgatcctttg tagctttttt 1042741 ctccgcaatc agggacaggc ttcatgttct tttgcaggcc tggcggttct tgatattgtt 1042801 cgggaaattc atcatgaaaa aatgctttta taggattcgt aagatttgaa tcagacatca 1042861 gcaacgctcc ttttctgttt ggtgtacatt cgtatgtgta cccctgagca taagcagaaa 1042921 aacatgtttt ggcagtttga atagtgaagg aaaaagaaaa caagaaaaaa caaagccttc 1042981 ttccatattt atcttgtcaa ataagactat atgaattatg ataaattcga gctataaatc 1043041 aactaaatat tgggtgttgg gagagtgaat cgtcatgaaa aaagcggcgg cggttttgct 1043101 gtcactcggt ctcgttttcg gtttttcata cggagctggc catgtggcgg aagccaaaac 1043161 aaaggtgaag gtctataaga actgcaagga gctaaacaaa gtatacaaag gcggagtggc 1043221 ccgcacatcg aaggtgaaaa acaaaggcgg aaaaacgaag tacaagcctt acgtttctaa 1043281 ggcactttac gatgccaata aaaacaaaga ccgcgataaa gatcttatcg cctgtgaacg 1043341 gtaaataaga aaaagcaatc tggtgtccag attgcttttt ttatgcttag gccgcctgat 1043401 cggccgcagc gcttttcgcc ttccttgtca taaggctgac tgccatcatg accgtgatat 1043461 tcaaaagcag ggcgacgatg ccgacattca agtcttttgc ggcttgcggc agagccggaa 1043521 ataaagtgcc gatcgtcgtt tccgtcattg taatataagt aactgctccg acacctgcaa 1043581 taatgccggc gaaagctcct tgctttgtca ccatattatg cttgagcagg ctgaacaaaa 1043641 gggcggggaa tagctgtgtg acaaggctgt agcccatcaa aagcagcgta acgatggtat 1043701 tcccgccttt gaaggtaaaa tacaccgaaa tcagcgcaat caccggcact aaaaacttag 1043761 caagcgccga tacttgctgt tctgtcgtgc ggggcgcgat taccttgtac acattttttg 1043821 caaacagtgt ggaggcggac attaagatca tagaccctgg cacaagtgct gtcagcagtc 1043881 cggcagcacc gataattccg acaaaccaag ggtcaaatgc ttgcagagac agtctcaaaa 1043941 gcgacaaatc cccgtctgcg ccattcagat ctggaacttg caggatagcc gcaaagccga 1044001 cgaaaaggac gaagagcagg accagctggt acaaaggcat gatgatggcg tttttacgaa 1044061 acacttttgg gttttcggct gaatacgaag cggaaaacgt gtgaggccac atgtaaaaac 1044121 caagcgctgt caagagtacg gttgaactga accaggccac actttgtccc gattcgggga 1044181 gcgtaagaaa gccaggcttt gccgtttcaa tctgctgaaa catgtcttga aatccgccgt 1044241 agtaatgaat tggcaaatac acacctaaaa acagaacgac aaccagaatc atgatgtcct 1044301 tcacaaccga tatccaggca gacccgtgaa tgcctgaaac cataacataa accgtgatgg 1044361 aaacagcgcc gatccagatg gcagcggtcg gggtgatttt gccgtacgag gtttccgata 1044421 caatcagccc gaggcctttc agctgcagta caagataggg aatgagtgcg gcgatgccga 1044481 ccagtgaaac gagaatgcca agcagcggac tgttgtattt ttttgtgaaa aaatcagact 1044541 gcgacatcag tttatgctgt ttcgcgtacg tccaaactgc tggaagaagc cagtaagaaa 1044601 ggatgtaggc cagacatccg taggcgatga tataaaaggc tggaccgcct tttccgtagg 1044661 cccagccgct gccgccgaga aacgtaaaag tagtataaat ttcgcctgcc atcaaaagga 1044721 agacgaaaac agttccgaag ccgcgccctc cgaccgtcca ctgctccagg ttcatgtctt 1044781 ttcctttttg ggcgcgtata ccgagaaaaa tactcaagag caggacaccg aagatgatga 1044841 tgagagctgc attcattctg cttcctcctt tttattttcc ttgtcgagga catacacaat 1044901 cgccatcagc gcagaggtca aaagagccca catcacaata taggcaagaa taaacggcat 1044961 gccgaacaca tagggggtca ccttatttgc aaaagggatg ccgagtaaga ttccgataaa 1045021 gggtaaagcg gcaagaacgt gaatcagttt catagaatcc tccttctatt taggattgag 1045081 gtgtacaagc ctaagcgtac tgaaaatgat gtcgcagata tcgcagcaca tgtcattttt 1045141 tggagtgaaa ggctgtggtt cgaattataa ataaatttat tttgtttgta tagtgtgaat 1045201 tgtctgaaat taatgctctg aatcgcccga agagggaacg ggcagtatga ttcaaaaggc 1045261 tcagagtctg tctggggcaa atagatagta tgttaataat tcgctgacct gctcacggat 1045321 tcgcggatta aaatagcgat ggttttcttc ataaccgtcg atgacaaatg tatagagtgt 1045381 aaaggcctca tcgcgttccg tctcgcggat tgcaattttt cttttcctca gttcttttct 1045441 gacctccatc aaatcctttt gtgctatttt taatgattcg ctgataagct gtttataagg 1045501 atgcttcaat tttaatgtgc tttcttcaat tccggcgaga tcacggttaa aaatcgtaat 1045561 ggccatgggc aaaaagagag cccgttcaat taaatcgtat atttcctcct gcagatttgg 1045621 catattgact ccttctttct aagggaacgt ttgttctatt tgtattctat atcggctggt 1045681 gaaatgtttc aagacagaaa aaatcaccaa aactttttag ttttctgctg ataatgtgta 1045741 gaataaggat agacaaaccc ggtaaggagt ataaatgttg gagcattttt tatcctattt 1045801 gacacaagaa catttaactg aattatttca aagctatagg gctttcggtc cgctcattgc 1045861 tgtgctgctg cctttaattg aagcatttct cccgtttttg ccgctgatcg tgtttgtggt 1045921 ggcgaatacg aactcgtttg gcttgtggga aggattcatc ctatcctggg cgggatcaac 1045981 tgctggttcc attctcgtct ttttgattgt ccgtcaatac ggacagagaa aattgcttgg 1046041 atttatccgc agtcatccgt ctgtcagaaa gctgatgtta tgggtggaaa gacacggctt 1046101 cggtcccatg tttcttctgc tttgttttcc atttacaccg tcagccgcgg tgaatgttgt 1046161 tgccggtttg tcaaggatcg gaacgcggcc gtttattttg gcggcagcct cggggaagct 1046221 tgtcatgatt tttatgatca gcttcatcgg atatgatctg cacgcgctga ttacacagcc 1046281 gattcgaacg gtcatcgccg tattggtgat cactgtctta tggtatgtcg gcaaaaaggt 1046341 ggagcggtat ctgcatgtaa gagccagtca gcgtgagcat gatggaggga gacagtaaca 1046401 tgaaaaaacg gttttggttt cttgccggtg tagtgtccgt tgttctcgcc attcaggtta 1046461 aaaatgctgt ctttattgat tacaaggtag aaggcgtcag tatgaacccg accttccagg 1046521 aaggaaacga attgttggtc aataaatttt cgcatcgatt taaaaccatc catcgttttg 1046581 acatcgtcct ttttaaaggc cctgatcata aagtgctgat taaacgggta atcggcttgc 1046641 ccggtgaaac gatcaaatat aaagatgatc agctgtatgt gaacggaaag caggttgctg 1046701 agccattttt gaagcatttg aaatctgttt ctgccggcag ccatgtaacg ggtgattttt 1046761 ctttgaaaga tgtgacggga acaagcaagg tgccgaaagg aaaatatttt gtcgttggag 1046821 ataatcgcat atacagcttc gacagccggc attttggtcc gataagagaa aaaaatattg 1046881 tcggtgtgat ttctgatgcc gaataaaaag acgctaattg aagaggcgtc tttttgtatg 1046941 ccgtttggaa aaatgtgttg aagaaaaatt tgtaaggagc tataatcaaa attgttacct 1047001 gtgtaacaaa atttatatat ttttttgact ggagggccgt ttttattggt ttttgttcgt 1047061 ttttcatgaa acaaaaggag tggtgaatga tgatgaaata tgaagcagtg attataggag 1047121 gagggccggt tggatttatg ctggcttctg agcttgcaat agccggagtg ggaacatgtg 1047181 tgattgaacg gcttgaaaaa cctgttccgc attccaaggc gttgacgctg cacccccgaa 1047241 cgctggagct tcttgagatg agagggattt tagagcggtt cgtatccaag ggaagcaaga 1047301 tacctaccgg acatttttca atgctggata cccgtctgga tttttcaggc ttggatacga 1047361 gctgtcctta cacgcttttg ctcccgcagt ccaaaacaga aaagcttctt gaagatcatg 1047421 cacgaagcct gggaacagag gtgtttcggg gtgccgaggc gctggcggtt acgcaaaacg 1047481 gggaagcggt ccaaacaatt tttaaggatc gggacggcag tgtacggacg atcacaagca 1047541 agtttgccgt tggggcagat ggcgccggga gtaccgtccg gaaacaggcg aaaattgagt 1047601 ttccgggaac agacagcact gtcaccgctg cgcttgggga tgtggtgctc ctttctccgc 1047661 cgccgtcagg tgtgctgtcc ctttgcacaa aagagggcgg tgttatgatt gttccgttat 1047721 ctccagaccg ataccgtgtc gttgtgatca gcccttatcg cacacaaacg ccgaaagatg 1047781 tgcctgtgac tgaggaagag ctgaaagctg acctcctgcg aatttgcgga actgacttcg 1047841 gtttaaccga cccttcgtgg atgtcgcggt ttgggaacgc cgcgcgccaa gcgaaacggt 1047901 atcgggacgg cagaatcttt cttgcgggtg atgccgcgca tattcatttt ccggcgggcg 1047961 ggcaaggact gaatgtcggc cttcaggatg caatgaacct cgggtggaaa ctggcggcgg 1048021 ccatcaaagg ctctgcgcct tcttggcttt tggacagcta ccatgatgag cggcatccgg 1048081 cagcggaagg gctcctcaga aacacggagg cacagacaaa gctgatcgat ttcactcaag 1048141 caggcctcca tttgcgaagc atgatgtcgg agctgctggc cttccctgat gtgaatcgat 1048201 atgtagcggg gcaaatttct gcgctcgatg tcagatatga agctgatcgt accatgccgc 1048261 cgaatcgttt gaacggggca aggctccctg acatgaagct gattctttcc gacggcaatt 1048321 cggaacggct gtacagcttt ctccaaaacg ggacattcgt tttgctgtca ttgaggcagg 1048381 aagctgatga tcatatcgaa gtaaaaggct tacgtacggt aaccgcctcg cttgcagaac 1048441 cgaatgaaaa gttgcggaat gtgcatacca tattgattcg tcccgatgga catgtagcct 1048501 gggcggtgga tgcatcagcg cccgattgtt ccgaggtgat tcaaaaaggg atcagccgct 1048561 ggttttccgt caccagccga gtataattca attcgattgt ttcatctgta acaaaacggt 1048621 atgatagaag aaacaatcga atgaaaaagg atggaaaacc cgatgaacac agatcatacg 1048681 aaacgcaatc tttttgaatt gtatgcggag ctcattcatc agcaggagaa atgggagggg 1048741 cttattaaag cctttttatc tgacgaattg aggaagctgg atgtagagca cgggagtaaa 1048801 tctcaattga cgatgacaga aattcatgtt ctatcctgtg tcggggacaa tgaaccaatt 1048861 aatgtcacgt cgatagcaga aaaaatgaat acgacaaaag cgactgtatc acgcatcagc 1048921 acaaaattgc tcggcgcagg cttccttcac agaacacagc tcagcgataa taaaaaggag 1048981 gtctacttcc gattgacgcc tgctggaaaa aagctgcaca gtttgcacaa atattatcat 1049041 cagaaggctg aacagcgttt tctgtcattt tttgaccgct ataccgagga agagattctt 1049101 tttgcggaac ggctgtttcg ggatctggtg acaaaatggt atccgtcgtc agaagaaatt 1049161 gaaggggggc ttcctagcat ttttaaataa aaaacacgca ctgcggtgcg tgtttttcgc 1049221 tttgtttcta tctttttcaa ggctgtaacg taaatcagat ttcctcttga agaatgaaat 1049281 tcaagatgtt caggaatttg cactgcttat acgatatgtc tattagtatc tttattttat 1049341 acgttttcta ctgtgttttt gatgctttgt tttcaagtga aatagggtct tctgttttag 1049401 ttctcctaat ctttacagaa atacctacta gaatgaccgc catagttgta aatattccca 1049461 tggttaataa gatcgtatcc tggtttaaac tccatccaat taagaaagag atgatcgctc 1049521 ctccgaaact tgccgaggca ataaataaac ttgtaacttc gtcaacgtac ttctgaataa 1049581 tgattgatgc tagtgttaaa gcaatgggaa atatccccgc tatacttagg ccaatcaaaa 1049641 atgtaccact caattgaagt attgggttac ttatataaga gaaggcaatc aacaaaacaa 1049701 ttaaacaact acagctaaaa agaaggtatt tggaaaaatc aagccttcta cttacgaaac 1049761 caatcaatat tcttcctatg atgatcccta cccagaaaaa ggagacactt ataagactaa 1049821 tttgttcatt gtcttggttt atcatgattg aaggtaaaaa gttggcaaaa tttgtttcaa 1049881 ttccagcata taggaaagcg aaaaatacaa aaaagcctaa ttgctttgat ttttttctat 1049941 ctcctataaa gtattgaaat gctcctccat ctggaaaggt cacttgttgg ttagcattct 1050001 tagcgtactc tcggttctta gacaagaaaa ttaaccaccc tacgaatagg acgaataaaa 1050061 aggtgaatat acagtaatat ggtaaaaacc agttattgat atctatgaag gaattaatta 1050121 ataatgggaa agataaagcg cctaatccaa agagaacttc cagcttactc attttttctg 1050181 cattactttc gaaattagca ataacaaatg aaccaactgt cgtttctaat gtgcctgctc 1050241 catatcctaa gagaaaagcc attacaataa tataatacca atccttggtt agaaaaaaga 1050301 tacttaacgc tacaagcatt attgtcaaag ctaaagtaag tgtcctaaaa tgactgtatt 1050361 tcttaatcat taaaggtgcg attaatactc cgcttagaaa tccggtaaac tggaagaaga 1050421 ttatgaccga aatatcatct gttgtcttgt taaaagcctc taataaaaat ggtgtcaaac 1050481 tccctgttga tatatggata atacctactg taaaaaagaa agcatatcca aataaatatg 1050541 tccctcttaa cattcattac acccctatat gaaaaagcag gaaagtaaat tcctgctttt 1050601 ttagtaactt ctctctttga aatactagtt gactgctgaa acagacatgg gttgagagtt 1050661 gctgtctttc tcaaagaaca tttctaatac ttcctgagat ctaaaaccat cactaaaaga 1050721 agggatctca acccaatcat tctgagttga tgcaatccaa ttgattaact cgcttctaaa 1050781 agaatcagcc catccataaa actcgtttgg cggatcgttt aataggcttt gcggtactgg 1050841 gcagtctacc acgttcaagc catctatgag cttgtaaacg tgaggattac ctgtgtggta 1050901 tttaaactct tttttgtgtc caactacctc aatgctaaaa ccacagtctt caggtacaga 1050961 acactttgat gtgatgatat ttacaaatac cttgttcttc agctggccat aaatttctgc 1051021 atagtcatct acaagtacct gtttatcctc ttttgttttt acatttgtgt tcatctttgc 1051081 ccttactgat tctgtgatga aatcactctc gaacaaatac cataccatgt caataaggtg 1051141 aatacccaga tcccccaatg atccactcgt cttcttacta ttagcgtcat ctctccaagt 1051201 aaacttctta cgtctaagtg cactattttt cttgaagtgt acttttatgg acagtatgtt 1051261 acctagttca ttattgataa ttaagctttt taagatattt acgtaagata aatatctata 1051321 attaaatccc atactggctc ttacgctcaa cctttcagca gtatctttca ttatgcttgc 1051381 ttcttcaaga gaaatagcca taggcttttc acataataca tgcttatgtt ttcctaatgc 1051441 ttgcaaagca tgttctttat ggcaaaagtt tggtgatgct acaattaaac cttctgaggc 1051501 atcaattagt tcatctacgt tttcaaatga cttcccgccg aaagttttca caaagctttc 1051561 cgcattttgt tgatttatgt catatacccc tactaactct gcatttttta ttgtagataa 1051621 agcagttgca tgcgctcttg caataccacc tgcacctatg atgcctatct tcttcatttt 1051681 tatttcctcc tcatgatcca attaattttt ttaaggtatt agtaattcct tttgagtact 1051741 cactatcagt tataaggttg tgcaagtttt tggcttcctg tgttgcattt tttagcagat 1051801 atccattccc tactgtctgt aacatacgaa catcatttcc actatcccca aatgcgatag 1051861 ctctttcggt atttaggttg tatttctcta acataaacgt tacaatttca ttctttcctg 1051921 tccctatggg gataaaatct acatcatagc tgtcttctgg atcgcctgct aagggattac 1051981 accgatttat atttactgaa acgccgtatt cttcgcagat tttttcaata gctaataggt 1052041 ttttcttgtc gtttatttca tcttgttcct gatagtagaa gttatgctta taccgtgact 1052101 ttcctaattg ggtttgagga ttcaaaagaa tgttatgatt ttcatgcagc tgtttcacaa 1052161 gtttttcaac cttttcttta ctaaaccctt catttatgcg actgttccac ttgttatctt 1052221 gctgaccgaa gttatgctct gaaaagtacg taatttcagt tccaagatca ctagctataa 1052281 aatgcggaaa atatctaaat tttcctcgtc ccattttatc gagaatagat tctatactgc 1052341 tcccagtaac ccatccgatt attagctccc catctttact tttttgttct agatagtctt 1052401 cgagttcata gatgtcttgt tgcttttgtt cgtcgattgt atgcggaaaa tacgtttcat 1052461 caaaatcaca aaaaacaata tattgaggat gttcaaccgt ggataacgtt ttatactccg 1052521 atttcttgct taataacatg aaacagtccc tccattactc tgtcttgttc ttctaaagta 1052581 aatgacggat ataaaggcaa atgcagtacc tgactatgag ccttttccgt atgaaccaat 1052641 tggagtcctg catacttgtc ctgtactaaa ggagtttttt gcatatgaga aagtattgga 1052701 taatatacat ctgtttgaac accaaaatct tcatttaatt tagtcatgat atctgcccta 1052761 tcttctgttc ttaccttaat aggaaacaga tgccatacat gatcttcact taattctggt 1052821 aattcaatat agcctttatt ctgcaactct gctaattggg taatgtatct atccgccaag 1052881 aacaatcttt tgaagttgtt taatgaaagg tacttcattc tctctaaacc aattgctgcc 1052941 tgtaaattgt ccatttttga attaaatcca aaattgatga ctttcttatt ttttacattt 1053001 acttcaaaac cgtgataact aaattgaatg cattttttag cgagttcttc attatcagtt 1053061 gctattgccc cagccttgcc acatacacca aaattcttat agggattaaa acttaatgta 1053121 gtgatgtctg catactttcc taagtctgtc agtccaattc cttggcaggc atcttcaatt 1053181 acttttaatt tataacgatt tgcgatttga cggatatgct gcatgtctga atgttttccg 1053241 tataaatgca caggtagaat aaactttgta taaggagtta ttgcttcttc aattttgtca 1053301 ggatcgatgc agaatgtttg tgggttaata tctacataga taggaacgcc tcccgaagct 1053361 aacacagcat tttcagtagc tgaaaagcta ttagccggca tgataacttc atcccctggg 1053421 tttaacccta aagccaataa acctatcata atagcatcgg ttccactgct ggttgcaatt 1053481 acataccttt tatgtaaata tgtagataaa actttttcga attgctctaa atagggacca 1053541 ctcgtaaatt ttccagttgg caaaacttca gttaatgtat ttaagatatc ttccacttca 1053601 tcattggtta ttaatctgtc tacaggcaaa aaagggactt tactgatttc acgatttttt 1053661 tgatagttga aaaggtcatg ttcaatatct atcttttctt ttaatacttg tttccaccgc 1053721 tcgtttacaa tactgtcttc aataacaagt tcttttcctt gtacgtcacc ttttaagtgt 1053781 tttaatagtg acatgttttc tttgctttta cctgaaatct taacctgttt ttgcatgaac 1053841 agtacctcca atgattttat aatctaaaaa tttattacaa atttatccta gtttctgaaa 1053901 tcggtaacat gtcaacaact tttttaagga agggaaaata tgcctacaat tgatgaaata 1053961 gcaaaattat gcaatgtgtc taaaaccaca gtgtcaagag tattgaataa tcatccttat 1054021 gtgtcgaaag aaaaaagaga tatgatctta aaggctatta acgaacttga ctacactccc 1054081 aattatttag ctcggaattt taggagaaat aagacacaaa cgatagcttt atcggttccg 1054141 agtatcgacc atccattttt tgctcaatta ataaaagggg tctctcatga agtactgttt 1054201 aagaattaca aggtaattgt atttcagacc ttttatgaca aacagacgga gctagaatta 1054261 ctagagttat tgaagcataa agaagtggat ggcattattc ttgggacttt agaaaatgaa 1054321 tgggatcaga tatccccttt cttaaagtat ggtcctatct tattatgtaa tgaatatcat 1054381 cactcagcgg acatcacgat aattgggtat gatgaatttg aagccgcata catgggggta 1054441 gtacatttaa ttgaaagagg gcataaaaaa attgggtttt gttttgatac tccatatagc 1054501 gaagctcaat gtcagaggaa agagggttat ttgaaagctt tacaagatta caatttacat 1054561 catagaagcg aatggatatt cggcgaaatg tttaatatcg aggatggctt tcgtgttttt 1054621 cataagataa aggatctaaa ggacagaccc tcagcaatat ttacaggaaa tgatcaagtc 1054681 gccgcaggga ttattaaaca ggcgatgaaa aatggcttta aagttccaga agacttagct 1054741 gtaattggtt ttgacaacca attgatttgc caagtcgtta ctccgaccat aacaacaatt 1054801 gatatccccg taatagaatt aggccaacag gctgtgttga aaatcatcga gtccatttcg 1054861 ggtaatgcct ctttaaacag aagaattatt aaactgccaa caaagcttat tataagagaa 1054921 tcaacgtaac gatagatttc cctttaacat tttatatctt tatataagaa aaagaggtta 1054981 ttcattttaa cctctttttc aatcgtaagt cgtcaattat ttctttcatt tcaccctctg 1055041 gcagcactca cttcaaatct gatccattaa caacgaaata tccgcttata tttcctcatc 1055101 tcgatggttt gcgaattaaa agttcttgaa cccttttttc aactaggcac tactgccgct 1055161 gattgagctc tttttgtctt ttttttcacc atgaagatgg tgaagcaggc gataaaacgg 1055221 cggcagcagg gcaataacca gaatgacgcg aatgacctga accgcaacga caaaggtgga 1055281 atcagcatgt aaggtaactg acgtcgtcgc catctctgca atcccgccgg gcgcaaatgc 1055341 cagaacagaa gtgatgagcg aaattcctgt cagctcggaa acgatcacgg cgctcaaaaa 1055401 cattgctgcg attaaaccga cggacgagac aaacccgacg atgataatac gggtgacgcc 1055461 ggcaaacatg cttttgtaca tcttagagcc gatcgttgcc ccgagaaata cttgtgatac 1055521 atggttagct tgtgacaacc accatgccgt catgtcgtgc cctgtcaccg cagctccgcc 1055581 aacatgtaca attgctacac cgagcatgct gccgagcagc catggagctg gaaattttaa 1055641 aaatttcgca gctttgcaag ctccccaggc agcgagaata agaatgacgg tccacaaaac 1055701 gggagcgagc ctaaaatctg tcgttgcaga agaaatcgtc tctgctgcgg cacttgcggt 1055761 acgatcttgt tttgtataga tcagaatgac taaaaacgga atggaaagca ccacgagcag 1055821 cacacgcatc atttgaacga ggctgactat agcggtattg gcgcctactt cctgtgcgat 1055881 gctcggcatg gcggaaagtc cgccgggagc ggtgccgaca aagctagtca tcatatccgt 1055941 tttgctgaaa cgccaaagca catatcctga cagcatggcc agcaggatag acaatatcag 1056001 cataacgccg actgaaaacc aatggtcttt gagaacagag agaacggata aattcagctt 1056061 ttggcccaat tcgatgccga ggatcatctg cccgagggcg agccatcgtc ggttaattcc 1056121 tttttggtct ggtgccatca tcagccatgc cggccgtatc atggcgaggc agcaggcgac 1056181 aatcagtgtt ccgatcatcc atccaattga tattccggtt aatgaaagaa taaacccccc 1056241 ggctgcactg attgcgataa accatagatc tttgaggaga ttttcgtctt tcttcaatgt 1056301 aaaacccttc ttcctttttc acgtaacact ccaattgttc acgtagtgaa tgtatttatt 1056361 actatagtat atttttgttg ataaagaaat tatgaattat tttctataag cgattcactt 1056421 ttcttatgac cttgtgttcg agcttttcta ttgtgtaagt cagagataaa cccgctgtca 1056481 gcagacacac ggcaagagcg taaaaaatca cttctccgcc aaatgatgtc aggatcagcc 1056541 cgcctgccag cggtccgatt gagcgggata tatcccaatg cagaccatag acagcataaa 1056601 accggcccag caaatgaggc ggcgccaatt tcgatatgaa ggtctggatg tgggttagcc 1056661 cgatgctttc accaaccgtc atcaccgctg ccgtcactaa aagcattgtc agagaggttg 1056721 agcatgcaaa gccggctgcc gcaagggagt agcaaatata agtaatgaag aggatcgttt 1056781 tcattgaaag cttttcggtc cctttgacaa gaggtacttg gagaacacag ctgaataaag 1056841 cttttgctgc tgaatagatg gtcagcatgg acagataatc agaaaacatg tttttgctga 1056901 acagcctgta tgttgtttct gtttgtgcat ataacatgct gatggggaga gaaagcagca 1056961 aaagaagcag gacaggcctg tatattgtaa agctcgcgga cattttcggg gtaacagctg 1057021 ggtgtagcgg ctttgtctca ggcagtttca gtgcagcgat cagaaagtag ataaacaatg 1057081 ctgcagcatc taatgcgaat atccacacgg ggttatgatt gtacagcagc atccccacta 1057141 gcggtcctgc cgtcagaccc gtcgaataga tcgcattgat gaccgcaaac acttccgaac 1057201 gtctgctttc cggcgtgctt tcagcgattt gggcgcggga agcgggaatg tacaacgatc 1057261 ttccgatgcc attcatgaca tagagaatag cgaaaacata cgcatgctca gcaaatacaa 1057321 accctgtcat tgccgctgat tgaagaagca atgcggtcaa aatcgctgtg cgccgcccaa 1057381 gccgatccgt cacccgtcct gcagcgagcg tcaggaaaat atcagcaaat ggctgaaggc 1057441 tgatgatcag cattggcatc atgatactgc cgtttaattg ttcatgcaga tacagcacca 1057501 taaaaggtcc catcattgca cctgtcaggc ttgtcagcaa ttcgccgaaa aagcggagcc 1057561 gaacgggagc ggtatatctc gattttatag agtgaaaact ggtcaacatg tgatcgccgc 1057621 ctttcgctgt ttgatatagt agtagtgtat agaaggggcg gcggcccaaa aagtgaagaa 1057681 aagaagagat aaaagttccc cttttgtcgg gaggtgcggg gattgaagct gatagagcac 1057741 tacgtggcgc ttgtaaaaac aggctgcgcc gagtatgggc aaatgaacga aatgacgctc 1057801 actgagattg ccgactgttt attttgtaca gaaagaaatg caaagctcat tttacataag 1057861 ctggagaaca gcaattggat tatccgggaa agcggggcgg ggcgcggccg caaatctaaa 1057921 atcgcgtttc ttcggaggcc tgaggaactg cttcttcaaa ctgcaaagga atataccatg 1057981 tcaggaaagc ttaaaaaggc aaaggagctg cttcagcagt atcagtccgc gtttccaggg 1058041 cttcaaaacg aatataacat gtggctatca gaggtattcg gatttgtgac ggagacaggc 1058101 gagaatgggg cgaaggatgt cctgcggctg ttcatcacgc ctgaatctgt cagcagtttg 1058161 gatccatgcc aaatattttt gcggtctgag ggccatttcg tcaaacagat atttgataca 1058221 ctcttcacgt ttgattcgga tatgcaggag ccgaagcctc atttggttca tggatgggaa 1058281 gaggtcggaa aaaaacaatg gagatttttt cttcgaaaag gtgtgttatt tcataatgga 1058341 cagccgctga catcgcggga cgttgcgttt acatttcagc gctttttgga actggctgac 1058401 aacccgtata aatggcttct gcacggagtg aaacaagtct tagaaaaggg cccttattgt 1058461 gtggagctca tactcgataa gccgaatgcg cttttgccgt atgctctttg tgatgaacgg 1058521 ctgtccatac tgccggcaga acagggcggc gggaaaaatg gaacagggcc ttttcagatg 1058581 aatcagcaac atagcgggat gcttgtgctt gaagccaatg agcgctactt caagggacgc 1058641 ccctatttgg atcgcgttga gtttgtgttt tctgagcaag ccggagagat gaacggtttt 1058701 accattcaag aaaaacaaac atgtcctgag cagcaaactg tctttgatga gcggcatgtt 1058761 cagtatttgt cgcttaatct gaaaaagaag gggcctcttc agcaccgaag ctttagaaaa 1058821 gcgctccggc tgctgatttc ctctgaacgg ctcgttcgtg aagcgggagg gcaccgaaga 1058881 attccggtta cgtccttttt gcatccgagt ccttttgagt gggagggcgt ttcgccatct 1058941 gaattgttga aaaaaagcgg atacgagggc gaaacaatcg tgctttatac cttttcggaa 1059001 acggatcatc gtgaggacgc cgaatggatt caaaatattt gcgcccagca cggtatcagg 1059061 cttacacttc aattctgtga tgctgctgat ctgcgacggc cggaaatcgt gcagatggcg 1059121 gatatcattc atgacagtgc gacgttttat caagacagcg agtttggttt tctgcatttg 1059181 ctgctgtcgg agaacagttt cttgtatcag catctatctg aaaagctgac acagatttgc 1059241 tcaggaatga cagagcggat gttttccatg cctgaccgct gttcgagaat caacatcctg 1059301 cgtgacattg accggcagat gatacaggag ctgaacgcga tcccgctgta tcaaaatgtg 1059361 ctccaggtga catcaagtaa aaatgtaaaa ggcctggtgc ttgatgaaga gggatggatt 1059421 gatttgtact ccgtatggct gtccaaataa aaagagggtt cttttttgaa ccctcttttt 1059481 tacgctgcca tgctgcggca ttgttcagca caggtgaagc aggctttcgc acatgcttgg 1059541 caatgatcat gatcgtgctt tccgcattca gtgccgcatg cttcacaaat atcggcgcaa 1059601 agtgcacaaa tttctttcat aaacgggctg tccgtttgca tggctttgac cgccagcgcg 1059661 caaatatccg cgcattccct gtcaagccgg atgcatccgc tgagatgatg ctgcacgctt 1059721 tcttccaagc atttagtgaa acaatgattg caagccttca tgcaatcgat gcaagcctca 1059781 atacaagcct cagaatattg ctccatggtt gattccccct gtatgacagt atatggtttt 1059841 atgtttcacg gctgcatttg aaaaaaacag gggagtgtgt ttttagctaa ggggatatgt 1059901 acatataccc tgaatgggta tatctaacgt tccatcagat agtataggaa ccagacagcg 1059961 tgattttgtt catcacgtgc tgcgcgcgta aagacgcctt tcgcttttaa gtttgacgtt 1060021 tcctcggccg cacgcaagta aaagtcgacg gtttcttgtt catctttaaa agcggcgtcc 1060081 agtcctcttg tgaaattgtc cgggcattct tccgtttgtt tcggcatgat gtgtttgccg 1060141 gtaattgaac catacagtgt ggaaaattca cggaggtggc gaatctcgtc acgcctgatt 1060201 tcttcaatct gttttctgac ctcatcgctg tgggcgagtt cggcaagctt gcggtagcat 1060261 tgaatagcac tgaattctcc gttgatggcc ttctgcaaat tccgaatcaa aacaggatct 1060321 tcccggtatg gcaccggata gggatagtag ctgtaatgca aggggattca actccattct 1060381 taggaattgg gcttctgtaa aagtatatgt tgggcaggga gagatgtgcg gagataatca 1060441 gctttttata tgtgaaaagg ccgtttttac caatagatca gattggtcat tttcgtcaac 1060501 attcgataaa atatagagag ataaaaagag aggggtcttc taatttggga gcagagtttt 1060561 tagtaggcag gtccgggagt ggaaaaacga agctgatcat caacagcatt caggatgaat 1060621 tgcgccgggc tccattcggg aagccgatca tttttctagt cccggatcaa atgacgtttt 1060681 taatggaata cgagcttgct aaaacgccag atatgggcgg gatgatacgc gctcaagtgt 1060741 tcagtttttc acgattggcc tggcgcgtcc tccagcatac gggaggaatg agcaggccgt 1060801 ttctgacgag caccggcgta caaatgctcc tgcggaagct cattgaggag cataaacagg 1060861 agttcaaagt ctatcaaaaa gcgagtgaca aaagcgggtt taccgcacag gttgagcgga 1060921 tgctgacaga gtttaagcgc tattgtctgg aaccggagga tatccgccgg atggcggaaa 1060981 gcggaacggc ttccgagtat cgcggagaac gtgttttatc tgaaaagctc catgacttat 1061041 caattctgta tcagcaaatg gaaaaaagcc tcgcagatca atatcttcac tctgaggatt 1061101 atttgacatt gctggcagag catatcccgc ttgcggaaga tataaaaggc gcccatatct 1061161 atgtggatgg cttttatcag tttaccccgc aggaattcag ggtgttggag cagcttatgg 1061221 ttcatgcgga gcatatcacg ttttcgctca cagcggacaa gccgtcatat gagcgggagc 1061281 cgcatgaact ggaattgttc agaatgacgg ggaaaaccta ttaccgcctg catcagaagg 1061341 cgaaggaact gaatttggac attacgtata aagagctgag cgggactgag cggcatacaa 1061401 agacgccgga attggcgcat ctagaggcac agtatgaagc gcgtccggcc attccatacg 1061461 cagaaaaaca agaagccctt actgtgatgc aggccgcaaa cagacgagct gagctggaag 1061521 gcattgctcg ggaaattcac gccctagtca gagagaaggg atatcgctat aaggatgtag 1061581 caattcttgc gcgccagccg gaagactaca aggatatggt gaaggaagtt ttcgcagatt 1061641 acgagattcc ttatttcatt gacggaaaag catctatgct gaaccatccg ttaattgaat 1061701 ttatccggtc gagccttgat gttctgaaag ggaattggcg ttatgaagcg gtgtttcgct 1061761 gcgtgaaaac cgaactgcta ttcccgctca atgaaccgaa ggccaaagtg agagaacagg 1061821 tcgatcagct cgaaaattac tgtatcgcct atggtattaa aggcgaccgc tggacaaagg 1061881 gcgatcggtt ccaatacagg cgttttgtgt cattggatga tgattttgcg cagactgatc 1061941 aggaaatcga aatggaaaac atgttgaatg acacccgcga ttggattgtt ccgccgcttt 1062001 ttcagcttca aaaacgcatg aaaaaagcga agacggttca agagaaggcg gaggcgctct 1062061 atcgttattt agaagagacg gatgtgccgc tgaagctgga tcaggaaagg cagcgtgctg 1062121 aggatgacgg cagaatcatt gaagcgcagc agcatcagca ggcgtgggac gcagtcattc 1062181 agctgcttga ggagtttgtt gaaatgatgg gagatgatga gatttctctt gatttgtttc 1062241 agcaaatgat agaagccggc gcggagtcgc ttacattttc tctaattccg cctgcgcttg 1062301 accaggtgtt tgtcggcaat atggatttgt ccagaatgta tggcacctcc tgcacctttg 1062361 tgctcggggc aaacgacggc gttctgccgg cacgccctga tgaaaacggg gtcctgtcgg 1062421 atgatgaccg ggaatggctg aaaacgattg gggttgagct atcctcaggc ggacgagagc 1062481 gtttgcttga tgagcacttc ctcatctaca tggcgttttc aagtccgtct gaccggcttt 1062541 acgtatcgta tccgattgct gatgcggaag gaaaaacgct tttgccgtcg atgatcgtta 1062601 agcggctgga agaactgttt ccgcatcata aggagcgcct gttaacaaat gaacctgaac 1062661 aggtcagcga tgaggaacag ctgatgtatg ttgtgaataa aagcgtggca cagtccttta 1062721 ccgcgagcca gctcaggtta tggactcggg aatacgacat cagcgacgtc tggtggagca 1062781 cgtacaatgt gctgatgagt gagcaggaca ggctgcaatc gaaaaagctg ttctcaagcc 1062841 tgtttttccg gaatgaagtg aagcagcttg aacgcagcgt gtcgagacag ctctatggtg 1062901 aacgtattca gggcagtgta tcgagaatgg aaacctttaa cgcatgcccg ttttcccatt 1062961 ttgcgtcaca cgggctgcat ttgaaggaac ggcaattctt caagcttgaa gcaccggata 1063021 tcggccagct gtttcattcc agcttaaagc tgatttcgga caggctgcgt gagcaaaagc 1063081 tggattggcg cgatttaacg aaggagcagt gcgagctgtt ttcctatgat gcggtagagc 1063141 ggctggcacc gaaactgcaa aaggaaattc tgctcagctc aaaccggcat tattatgtga 1063201 aggaaaaact gcaaaaaatt gtgacacgtg tgtccggcat tttaagcgag catgcgaaag 1063261 cgagcggatt cgtaccgatc gggcttgaac tgggctttgg aggaaaaggg ccgcttccgc 1063321 cgctgacctt tcaactgaaa aacggctgta cgatggaact cgtcgggcga attgaccgtg 1063381 ttgataaggc tgaaagctca aaaggcctgc tcctcaggat tgtcgattat aaatcaagcg 1063441 acaaaggcct tgacttagcg gaagtatatt acggattggc actgcaaatg ctgacgtacc 1063501 ttgatttatc gattacacat tcagctgact ggctcgggat gagggcgacg cctgccggag 1063561 tgctgtattt ccatattcat gacccgatga ttcaatctaa tctcccgctt gggcttgacg 1063621 agattgaaca ggagatcttt aagaaattta aaatgaaggg cttgctcctc ggtgatcagg 1063681 aagtggttcg cctcatggat acaacccttc aagagggacg ttcaaatatc ataaacgccg 1063741 gcttgaaaaa agacggctct ctcagatcag actcagcagc agtcggtgaa aaggaatttg 1063801 atcttttgac aaagcatgtg cgccgcacct tccaagaagc gggcgaacaa atcaccgacg 1063861 ggcgcgtatc cattgagccg tacaaaatga agaacaagac gccgtgcaca tactgtgcgt 1063921 tcaaatcagt atgccaattt gatgaatcac tggaagaaaa cgagtatcgc ccattaaagg 1063981 ctgaaaagga caagacaata cttgagtgga taaaaaagga ggcggatggc aatgaacatt 1064041 cctaaaccgg cagacagcac atggacagat gaccaatgga atgccattgt ttcaaccggc 1064101 caggatattc ttgtggcagc ggctgcgggc tctggtaaaa ccgctgtgct cgttgaacga 1064161 atgattcgga aaatcaccgc ggaggaaaac ccaatagatg tagaccgtct tctcgttgtg 1064221 acatttacaa acgcctcagc ggcagagatg aagcaccgaa tcgcagaagc cttggaaaaa 1064281 gagcttgtac agcgccccgg ctcgctgcat attagacgcc agctgtctct tttaaaccgg 1064341 gccagcattt cgacgctcca ttccttttgc ctgcaagtgc tgaagaaata ttactacttg 1064401 atcgatcttg atccgggctt tcggatagct gatcagacgg aaggcgagct gatcggggat 1064461 gaagtgcttg acgagctgtt tgaagacgaa tacgcaaagg gcgaaaaggc gttttttgag 1064521 cttgttgacc gctatacgac agaccggcat gatctggatc tgcaatttct cgttaaacag 1064581 gtgtacgagt attcccgatc ccatcccaac ccggaggcgt ggctggaaag ctttgttcat 1064641 ttgtatgatg tatcagaaaa gagcgccatc gaggagctgc cgttttatca atatgtcaaa 1064701 gaagatattg caatggtgct taacggggcg aaggaaaagc tcttgcgcgc gcttgagctg 1064761 acgaaagcgc cgggcggccc ggcgccgcgt gctgacaatt ttcttgatga tcttgctcag 1064821 attgatgaac tgattcagca tcaggacgat ttcagtgaac tatataagcg ggtgcccgcc 1064881 gtctctttta agcgtgccaa agcagtaaaa ggggatgagt tcgatccagc gctccttgat 1064941 gaggcgacag atttgaggaa cggcgcaaaa aaactgcttg aaaagctcaa aaccgactac 1065001 ttcacgcgaa gtcctgaaca gcacttgaaa agcctagccg agatgaagcc tgtcattgaa 1065061 acgctcgtac agcttgtcat cagctatgga aaacgattcg aagctgcgaa acaggaaaaa 1065121 tcaatcatcg atttttcgga tttggagcat tactgtttag cgattttgac agctgagaat 1065181 gacaaaggtg aacgtgagcc gagcgaggct gcaaggtttt atcaggaaca gtttcatgag 1065241 gtgctcgttg acgaatatca ggataccaac ctcgtgcagg aatcgattct gcagctcgtc 1065301 acaagcggtc cggaggagac tggtaacctg tttatggtag gagatgtcaa acagtcgatt 1065361 tatcgattca ggcttgcgga gccgcttctt ttcctctcta aatacaaacg gtttacagag 1065421 agcggagaag gcacggggcg gaaaatcgat ttaaataaaa atttccgaag ccgggctgat 1065481 attttagaca gcacaaactt tttatttaaa cagctgatgg gcggcaaaat cggtgaggtc 1065541 gattatgacg agcaggctga gctgaagctt ggtgcagcgt atccggacaa tgacgagacg 1065601 gaaacagagc tgctgctgat cgacaacgca gaagatacgg atgcaagcga ggaagcagaa 1065661 gagcttgaaa cggtgcagtt tgaggcaaaa gccatcgcta aggaaattcg taagctgatt 1065721 tcatcgccgt ttaaggtgta tgacggaaaa aagaaaacac atcgcaatat tcaataccga 1065781 gatatcgtga ttttgctccg ttcgatgccg tgggctccgc aaatcatgga ggagctgaga 1065841 gcacagggca taccggttta cgccaattta acgtcaggct attttgaagc ggtcgaagtc 1065901 gccgtcgcgc tttctgtgct gaaggtgatt gataatccgt atcaggatat accgcttgcc 1065961 tctgtgctgc gctcaccgat tgtcggagca gatgaaaacg agctgtcttt gatccggctt 1066021 gaaaataaaa aagcgccgta ctatgaggcg atgaaagact acctggctgc tggtgaccgg 1066081 agcgatgagc tttatcaaaa gttaaatacg ttttacggac atctgcaaaa atggcgcgcg 1066141 ttttcgaaaa accactcagt atctgagctg atttgggaag tgtaccgcga caccaaatat 1066201 atggattatg tcggcggcat gccgggcgga aaacagcgcc aggccaattt gcgtgttctt 1066261 tatgacaggg cgcgtcaata tgaatcaacg gcatttcgcg gcttgttccg tttcctgcgg 1066321 tttatcgaac gcatgcagga gcggggcgat gatcttggta cggcgagagc gctcagcgag 1066381 caggaggatg ttgtccgctt aatgacgatc cacagcagca aagggctcga atttccagtc 1066441 gtgtttgtag caggtctcgg ccggaatttc aacatgatgg atttgaacaa atcgtacctg 1066501 ctggataagg agctcggatt tggcacgaag tatattcatc cgcaattacg catcagctat 1066561 ccgacacttc cgctcattgc gatgaagaaa aaaatgcgca gggagctgct gtcagaggaa 1066621 ttgcgtgtgc tctatgttgc attaacgaga gcgaaggaaa agctgtttct gattggctca 1066681 tgtaaggatc atcagaaaca gcttgcaaaa tggcaggcat ccgcgtccca aactgattgg 1066741 cttctgccgg aatttgaccg ctatcaggcg agaacgtatc tagatttcat tgggccggct 1066801 cttgccaggc acagagactt gggggatttg gctggtgtgc cagcacacgc tgacatctca 1066861 ggtcacccgg ctcgttttgc cgttcaaatg atccattcct atgatttgct tgatgatgat 1066921 ctggaagaaa gaatggaaga aaaaagcgag cgcctagaag cgatccgccg aggtgaacca 1066981 gttcccggct cgtttgcgtt tgatgaaaaa gcccgcgagc agctgagctg gacctacccg 1067041 catcaagaag tgacgcaaat tcggacaaag caatcagttt ctgagatcaa gagaaaaaga 1067101 gagtacgagg atgaatacag cggcagggcc cctgtaaaac cggctgatgg aagcattctg 1067161 tacagacgtc ccgcttttat gatgaaaaaa ggcctgacag cggcagagaa agggactgcc 1067221 atgcatacgg ttatgcagca tatcccgctg tcacatgtgc cgtcgataga agaagctgag 1067281 cagacggttc acaggcttta tgaaaaagag cttctcactg aagaacaaaa agacgctatt 1067341 gatatagaag aaatcgtgca atttttccat acagaaatcg gcggacagct gatcggtgct 1067401 aagtggaagg accgggaaat accattcagc ttagcgcttc cggccaagga gatctatcct 1067461 gatgcacacg aggcagatga gccgctttta gtgcagggta ttattgactg tctctatgaa 1067521 actgaggacg gattatatct attggattat aagtcggacc ggattgaggg caaattccag 1067581 catggatttg aaggagcggc cccgatcttg aagaaacgat atgaaacgca aattcagctg 1067641 tacacgaagg cagtggagca aattgcaaaa acaaaggtaa agggatgtgc gctttatttc 1067701 tttgacggag ggcacattct gacattatag cgagatccat aagctccgga atttcaggcg 1067761 gagcgggtct cgttttctat ataaaagaga ggtgaaagca tttgcggatt ttacatacgg 1067821 ctgactggca tcttggaaaa acgcttgaag gaagaagcag gctgagtgaa caggccgatg 1067881 tgctggatga actgaatacg attgtaaagg atgagcagat cgatgccatt gtaatggcgg 1067941 gggatgcatt tgacaccgta aacccgccag ctttagccga gcagctgttt tatgaaagcc 1068001 tgtctgcgct tagcgacaga ggaaagcgcc cgatcgtcgt cattgccgga aatcacgata 1068061 atcctgaccg tttgtccgcc gcttcaccgc tgacacatga aaacggcatt catttaatcg 1068121 gttatccgac aacagagccg attcatattg aagtgccttc agcaggagag cttttggcgg 1068181 ttggagcgct ggcgtaccca tctgaagcgc ggttaaatga agtgctatcc gatacgtttg 1068241 atgaaaagct gctccgtgat cactatgatg tgaaaatcag gcaggcgttt gagcatatga 1068301 caagccggtt ccggaccgat gcagtgaaga ttgccgccag ccatatttat gtggcaggcg 1068361 gaaaccaaac cgattcagag cggccgattg aagtcggcgg tgcatacacg gtggctgctg 1068421 aaagcctgcc ggcagatgcc gcttacgttg cgctcggcca tttgcatcgc ccgcaaacga 1068481 tcaagcgggc gcggacgctt gcgcgttatt caggatctcc gctcgcctac agcttttctg 1068541 aagcgggcta cgctaaatca gtgacgattg tggacgcaaa gcctggggaa gaggccactt 1068601 ggcaagaggt gttattatca agcggcaagc cacttgtgaa gtggaaagcg gcaaatggat 1068661 taagtgaggt gtacagctgg ctggatgaag gcagagatca gaatgcttgg attgacttgg 1068721 aaatccgtgt cgcggaccag ctgtcacttg aagagattca caggctgcgg aaggcgcacc 1068781 cgggctttat ccatatcagg ccggtttttg aagaacagaa caaagaccgg gaacggatcg 1068841 aggttaaaca tgtctcaatc gaggaccgct ttaagaaatt ttatgaaaaa caaactggcg 1068901 gtgcggtgcc ggatgaagaa atggtgaagc tgtttttaga gcttgcatca ggcgttgaag 1068961 aggaggatgc gaaatgaagc cgatcgcctt aagcattaag gggctccaca gctttagaga 1069021 ggagcagacg atagattttg aaggcctttc cggtgccggt gttttcggca ttttcggccc 1069081 gacaggaagc ggtaaatcct ctatactcga cgcaatgacg cttgctttat acggaaaggt 1069141 ggaacgggcg gcgaataata cgcacggaat cttaaatcac gccgaagata cgctgtctgt 1069201 gtcctttacc tttgcgcttc agacgaatca ccaaatctca tacaaagtcg agcgtgtgtt 1069261 taagagaacg gatgaaatga aggtaaaaac ggcactttgc cgcttcatcg aaatcaagga 1069321 cgagcatacg gtgctggctg ataaagccag cgaagtgaat aaaagagtgg aggagctctt 1069381 agggctgacg atcgacgatt ttacgagagc ggtggtgctg ccccaaggga aatttgctga 1069441 atttctgtct ttaaaagggg cagagcgcag gcatatgctt cagcgtttat ttaatttgga 1069501 gcaatatgga gacaggcttg tgaaaaagct gagacggcag gcgcaggaag ccaatgcgag 1069561 aaaaaatgaa atgcttgctg aacagtccgg tctcggtgag gcgagctcag aggcagtgga 1069621 gcaggctgaa aaggttctcg aacaagctga agcccggctg gaagcgatga ggaagaaccg 1069681 tgatcaggcg aaggagcggt ttacagagca tcaggagata tggaatgtcc aaaaggaaaa 1069741 atccacttat gaagaagagg aaaaacgtct cgcagaagaa cagccgcata tagacagcat 1069801 gcaaaaacgc ctgctggaag cagaaacagc agcagccctt aagccctatg cggaccggta 1069861 cgcagaagcg atccagcatg aggagcaagc tgaaaaggaa caaacgctag cccaaaagga 1069921 tttagcagac cggacagctt tctttcagca aaaacatgaa gagtatgaag cgtggcgcca 1069981 gcataaaagc gagaaagagc ctgagctttt agccaaacag gaacagcttt cacgcttgca 1070041 ggaaatcgaa atcaaactga gtgaggccaa gcaagaggaa gagcgcaaaa aggctgacct 1070101 ccggcagaaa gaagaggctc ttcaatctgt catgaatgaa ttagagaccg taacagaccg 1070161 cctgacacga gggcaaaaca gacagacaga attgaagcag cagctcaaat ccctgcaggt 1070221 gacatccgat gagcgaaaaa gctgccagca ggccgcagag atggcattgc gcatcagaca 1070281 aaccgaggaa caaatcaaaa aagagaaaaa acgaagtgaa gaattgaacc tcgtgctgca 1070341 gaagatgaat gaagagaaga atacactcgt tcaaaagacg gaagcggaag aaaacaacat 1070401 cattcaggca tatgaggcag ttcaaactgt gtaccatttg gtgtgcgaaa cggaacgctc 1070461 attaacacgt atgacggaag aggctagaaa gagtcaacac acgcttcact tacagcgtga 1070521 aaaagcaagg gtggcactgc tgacaaaaga gttagcccaa aagctgactg ccggaaagcc 1070581 ttgcccggta tgcggttcaa ccgatcatga tccatctgcc tcggtacatg aaacgtatga 1070641 agccgacagc catcttgaag aggacatcaa acggacagat gtgttattga cggaagctgc 1070701 agctctcagc caggagattc tttcagccaa aattatgctt gaagaacagt ccgcgcgctt 1070761 tattgaacag tgtccgtttt tgcagacaat tcaagcacag aaccttgaag cggcagcttc 1070821 cttcgaacat cagccggtgt atgaagcatt tgaaactgcc aaatttgaat ggaaacgaat 1070881 caagcaggac attctttctg ttaagacacg aatggcacaa atgattggcg cctatcagga 1070941 gtctttaaaa aaggccgagc agcttaatga aaaaatcggt tttgaaaaaa gagaagccga 1071001 ccgtattgaa agcatcatca gtgagcttca atcctcaatg gacagcagtc tgaacatgtt 1071061 taaagaagca tttcagaatc aatctgtgga cgaagcagaa aaatggcagc aagccattga 1071121 agaaaaggac cgggctgcag aagaatgtga aaaacgaatt gagaagagta tcgcgtttct 1071181 tgctgagcat gaagcacaaa aggaaaaact gcgggaatcg ggacaccggc ttgagcggga 1071241 aaagctggag cttcattatg cggctgaacg catcaagagc gtgatagctg attatgagca 1071301 cgaactcgga gattatgcaa aaggagattc gattcaaatc aaactccgct ctgtccagca 1071361 ggatctaaag ctgttaaagg aaaaagaaca atctttatat gaagaactgc aaagcgccca 1071421 aatgaagctc aaccaagcga aaagccgcgc ttctgcaagc gagctcactc ttcaagaggc 1071481 gaagggcaga ttggaaaaag caaaagctgc ttggcttgag catacaaaaa acacctccat 1071541 tacccggact gaggaggttg aacaaagtct catcccagct gatgaacttg aaaagatgaa 1071601 aaccggcata gaccagttta tggataaact gaagcaaaat gctgcaaact taaaacgagt 1071661 agcagagata cttgccggca gagcattatc agagagcgaa tggaacgaaa ccgttgcagc 1071721 attacaagaa gctgaggacg catttggcgc tgctatagag gaaaaaggcg cggccgcaaa 1071781 agcactggct gtcattcgcg accatcataa acggtttaat gaaattgaag ctgaactgaa 1071841 aaaatggcag atgcatatcg acaggctgga caagctgcaa gctgtgttta aaggcaatac 1071901 cttcgtcgaa tttttagctg aggagcagct tgaaagcgtt gcgagggacg cctcagcaag 1071961 actcagtatg ctgacaagac agcgctatgc catcgaagta gattctgagg gcggcttcgt 1072021 gatgcgggat gacgcgaatg gaggcgtacg acgcccggtt tccagtttgt ctggaggaga 1072081 gaccttcctc acctcgcttt cacttgctct tgcgctgtct gcgcagattc agcttcgggg 1072141 ggaatacccg ctgcagttct ttttcttaga tgaaggcttc ggcacactgg atcaagatct 1072201 gcttgatacg gttgtaacgg ccttggaaaa acttcagtca gacaacctgg ctgtcggtgt 1072261 catcagccat gtgcaggaac tgcgtgcacg gcttccgaaa aagctgatcg tccatccggc 1072321 tgaaccgagc ggccgcggta cgcgggtatc acttgagttg atgtaaggga ggagcggata 1072381 tggcaaagca gattgccgga atatgtgagc tgtgcggccg gagcgatgtc cagctgacag 1072441 agcatcatct tacaccgaaa gaggaaggcg gaacgttttt gccgacagcg atgctctgta 1072501 ttccttgtca taaacagatt catgccttat ataccaatca agagctcgct gtacgtttaa 1072561 atggaatggc tgaactcaga agcgatccag agcttgcccg gtttgtcaaa tggatcagaa 1072621 aacagccgcc tgagaagctg atcaaaacta agaaatcaaa tgaacgaaaa aagaaaaaat 1072681 gactaaaaag cagccctctc tttgcagagc ggctgctttt atccgtttcc aaccatatcc 1072741 tgatcgttga catcggggtc tatataattt gtcgcgttga ctgcattatt taatagaagg 1072801 aaatctcccg tgtttcctgc tcccgaaccg agcgcagatt ttgaagagct tttcggagaa 1072861 aggtaaaagg aatcaccaaa gtttacgact ccgcccgata tggaattgat agctataggc 1072921 ccgacaattg ctggcataaa cgacaccctt tatcgaagtc tctgtttatt atatgttctt 1072981 ggcgggcgat tgtgagcgcg gagactgaat ctgtctgata tgtttgagtc tcgcatcacc 1073041 gcgaataagc gaagctgatc cggcatgtaa aacagaagag gctgagaccc cttgaatttt 1073101 gatgctgcga acataaatag ccggcacctc gtggcaaaac gcgctttgta cacctgtttc 1073161 ggggagcggc ttcacggcct gctgctgaaa gatctgatac tcctttttgt taaatgagcc 1073221 ttcattatgg taaaacgtgg acagagaacg ctgcacagca aatactttta cactcatatc 1073281 gatttcattt gtgtcgccaa cttgaaacac acttgcgatc ccgagagaat taaacttaac 1073341 tagtctgatg cgcgatatgc gtttaagcat tattctggcg caagcggagc aaacggccca 1073401 ataataagag attcaggcgg tgtatcaaaa atagaagaca ggtagatgga ttcagtgtct 1073461 ccgatgtgga aaacggagga actggacaca ccgttcatcc gaatatcccc gacttccaag 1073521 ctgcggttga tgactgtaaa gatcatgctt gctcatctcc tttcatttct gatggaatat 1073581 gctccagaaa gtgttctaca gcgcggatga catcacgctt cacatgctca gcgatatgtt 1073641 ctgcatattg tgcaggcggt gtattttctt cttttttgat atgggacata taatagtgaa 1073701 tcctgctgtc catttgtttt ctgatgtctt caataacatg atgtctgttt gtatcgtcaa 1073761 gtctgctgtc atattgattt tcaagctgtt ccaaaatatc tgggatttcc tcggttaagt 1073821 acatgtcgac attctggcgg atctgctgca tgagctgagc gctctcttcc tgctgcatca 1073881 tcccgatttg cggtgtcgac tggctgacgt caaagttttg gacgctgttc gggtcagtcg 1073941 gatttaaacc gatattcaaa gtcccgtcga gcctttcgat tttcagctga tcaaatttat 1074001 actccacacg ctcaatggta gtggccggcc gctgtttcat cgtattcatt tcagtttgaa 1074061 tctctttcag ctgacgttcg agctgctgaa tgtgaatcgc ctgctgctga acgaaggaat 1074121 tcaagttttg caggtaagag gaaacagatt gatcatacat gttcttcacc tctttcatat 1074181 gattaacggc caggaggctg gagcgggacc aatgaacctg tgtcgggctc ctgcagctgg 1074241 agcggttgcc ctgagccaga aacttctggt gccggctcta catagcttcc tgtattatac 1074301 aaatttgaca gtgacttgat tgatccggcg ctcccgattt gcagaatgga ggagttgctg 1074361 attgattcca gccggagata gttgatttga atggtttgat taatatagaa gttcatgagc 1074421 ctcactcctt ttacgcattg gccacgatcg gctgatcaac cgcatcattg tcatacacat 1074481 tcgtcgcgtt ttgataattc atcaccttga ggctgtcgcc ggtattaaag ctgccagcac 1074541 cggcaaacgt tctgacctga gcctgaggag aaatcgtaat gcagtccccg atgtgaacga 1074601 ctccgctcgt accaatcgca ttaattttaa acgctccgac aatggccggc atacgagcac 1074661 atcctttgtt gaaaaattaa aaaaagacag gtaaagtgaa atgacaattc cgatttcaat 1074721 tgggctattc acgatagctt atgacaaacg cacatatgtg tgagagaaat tttaagggga 1074781 catatcggct ctttgtgaaa gcgttttatt ttttcgggcc gttatgttta aacatggcaa 1074841 aagaggatgt tgggtataaa ttgagcggaa atgcggcgaa ggatgccgct atccgcctat 1074901 ggtgattttt gtttatttct ttggtgtttt tgcgtgtaga atgctttttg gagtatgtcg 1074961 tgctgcggta ttcgattttt gggcgggcac attctcgccc tgaggtatat ctcagaagtg 1075021 ctgagcaaaa atcggagtta aatgtggtgt attctaattg ttatagaaaa tgatttacat 1075081 acgggagttt tcaagatatc tcccaaaaat catttcttct ttaatccggg tattcagcag 1075141 gatatccagc tcttggctgc attgaatcgt ttcttttgaa ttcatgccgt atttttgtgc 1075201 ggtttcaatt agtgtgatcc tcatttcttc aattttactg ttcattacgc tatctccaat 1075261 tctagatttt attttgatat aaatacagga tatcgttagt ataacctatt ttggctcaaa 1075321 aggttgcctt tcgtcaattt gactaaaaaa gcgacaattt ttgctgcggc cttttttaat 1075381 ggagaaagga ctaaagtctt gctaagtgtg cttgcaaaaa gtcctgccgt tcctcaattt 1075441 ctctaagtat gttggtctgc tccttttcga tttgaaaggg gctttttttg ataaaaggat 1075501 catcagcagc actttgacaa atgtcaaggt gccattcgtt gatgagagga gataatcgtt 1075561 caatagtaaa cgaccgcttc agcacgtttt tcattaaggt gtgatattgc gacctgaagg 1075621 cgggaatgga tagaagcctt gacgaaagcg tctttccttt tgtcagaagc gggtcttctt 1075681 cataccattc ttgtacggca agcgatcttg tctccatcgg ggaaacgtaa agccgaccgg 1075741 attcgtttaa acaaaatgtg tagtaaaagc cttgattggt gcaggtgttg ccgatcagcc 1075801 acaaaaaaaa cagcttgaca tccagataca atttaatcct ttcagccaat tcgtcatctc 1075861 cggctgtgcg gatcagtatg aaaaattcat gtaagaatgc cgaggaatca ttgttaaaaa 1075921 gggacaatgg aacccttgga tcggccgtct tcactccgta actcctttta ccggctggct 1075981 gatggttctt gatgttcaaa taaatgcctt caggctggcc attgatggtc agaaagctgt 1076041 acgaggcaac gggagcaggt acgccgatct ggtcaaaaaa acaataggcg agtctgcgcc 1076101 gcatcaggga cggatcatcc tgttctgcat tcaaaaaaag tgtcctttca ccaagcagag 1076161 acttttccca gctgatttca taggatgcct tttccgctct gtcacgctgt gtgagaagaa 1076221 tgggagaaac agatcgatct gttacgaaaa gccccttggc tgtacctttc cttttcagct 1076281 gctcccgatg aaaaaataaa tgcacgcgct ccatattctt tcctccttct caaaacgaca 1076341 tttgtatgat atgtagagca agcccgtcct gaaacgaaat gaaaacggaa ttgagaaaaa 1076401 gggatttcag cattcgacag agaatacatg aaggagcatt ctgatttaaa agatgatgga 1076461 ggaataacat gaaatttgcg acaggggaac tttacaaccg aatgtttgtc ggcctgatca 1076521 ttgacgatga gaaaattatg gatttgcaga aggctgaaaa aaaactgttt gaacttgaga 1076581 cgattccggg atcgctgatt gaatgtatcg cagaagggga taaattcgtt gcgcatgcaa 1076641 ggcagctggc cgagtgggca aagaaaccga atgatgagct gggatcattt atgtattcat 1076701 tatctgaggt gaagctccat gcacccattc cgaagccatc aaaaaatatc atctgcatcg 1076761 gcaaaaacta ccgggatcac gcgattgaaa tggggagcga ggctgatatt ccggagcatc 1076821 cgatggtatt tacaaaatcg ccggtaacgg ttacggggca tggtgatatc gtaaagagcc 1076881 atgaagaggt tacctctcag cttgattatg agggagaact tgctgtcgtg atcggaaaaa 1076941 gcgggactcg catttcaaaa gaagatgcat atgaccatgt tttcggatat acgattgtga 1077001 atgatatcac ggcgcgtgat ctgcaaaaaa ggcataagca gttttttatc ggaaaaagct 1077061 tggatacgac atgtccgatg gggcccgtgc ttgtacataa atcatctatt caggagccag 1077121 agcgcctcaa ggttgaaaca agagtcaacg gcgagctgcg ccaatccggt tcggcaagcg 1077181 atatgatctt ttccattccg gaattaattg aaaccctctc aaaggggatg acgcttgaag 1077241 cgggcgacat tattgccacc ggtacgccgt ctggtgtcgg caaggggttt acgcctccaa 1077301 aattcttgcg gtcaggtgac aaaattgata ttacaattga tccgatcgga acgctgtcaa 1077361 accaaattgg ctgaataaaa ctggagggcg gacccggacc cgcccgtttt ttctgataat 1077421 catctttgtg acagaggaca agttcatggt actataagtg gggtaattta tctgataggg 1077481 ggaacatata tgacacacct acatattacg acatgggtgg tagcgctgat tctgcttttc 1077541 gtcagctact cgctgtattc gtcaggaagt gcaaagggcg caaaaatcac tcatatgatt 1077601 ctgcggttat tctatatcct tattattttg acaggagctg agctgtttgt ccgtttcgcc 1077661 aactggaacg gagaatacgc cggcaaaatg attctgggca ttatcaccat cggcctgatg 1077721 gaaatgctcc tcatccgcaa gaaaaaagaa aaatcaacag gaggcctgtg ggtcggcttc 1077781 gtcattgtcc ttttgctgac agtgctgctc ggtctgcatt tgccaattgg ttttcaattg 1077841 ttttaataga aaaacctatg aacccggctc tttgatagag ctggtttttt ttatatttat 1077901 cccctcatat tccaaatcat ttaaaataac cttaaaattc cctgtaagcg gtatctcgtc 1077961 ctatgaaatt atgatacctt caaggagatt cattattttg caggagggat aacatgaaac 1078021 gcagaaaatt cagctcggtt gtggcggcag tgcttatttt tgcactgatt ttcagccttt 1078081 tttctccggg aaccaaagct gcagcggccg gcgcgatcga tcaggcggct gctctggaaa 1078141 acggcaaaga gcagacaggc gccatgaagg agccggaaca ggtgaaatgg tacaaagtga 1078201 ccccgggagc aacggatatt cagaaaaact cacatatggc actgaccgta aagagtgatt 1078261 cagtactgaa tgtatctgta tatccaagta aggaaaaagc gcttaaagat gagacgtttg 1078321 agatgtaccg ttctttcaca gcggaggatg gaaaaagcga agtcattttt ccatacgcgt 1078381 ggagcggccc ttactatgta aaagttgaat acctcggaga agaagaacca gaggacggcg 1078441 gaacggcaga agcagctgca gaagccaagt atacgattgg gtataaaggc accaaaaaac 1078501 agccgtcaga tttagaagag gaagaagctt gtccggttga aatgagtgtc gatcagaaga 1078561 aatcaggaaa aggcatcctg gataagttga gatcgattcg tgatgagcag ctgagccaaa 1078621 cagcagaagg caaagaactg acaagccttt attacaaagc agcaccgttt atcgttgcaa 1078681 agctcgcact caataaaaca gcaagaaatg aaatctatca ggatcttgtg acattaaagc 1078741 cgttatttga cgatgtgtca gaaaacggag catcatcttc gtataaggtc actgaaaagg 1078801 atcaaaaagc gatcaaccgg ctatatgata aagctttaca atcagtcccg tcattcctta 1078861 aagaggagat aaagaaacaa gcggaccgac taaatatgaa gcagctgcaa ggcaaaacag 1078921 caggagccat tttaacagaa aacaatattg cagcaaaaag tgaagttcag acaacaaagg 1078981 ttattttcaa ggtgaaggac aataaaagcc tctcatccgt acataatgaa atgaagggct 1079041 tttctgcaag cgcgcaatcg aaaaaagaca tatctaatgt gaaaaaggca aagaaactgt 1079101 ttgacaatct gtattcattt gaacttccga aagacgagaa acagaacggc gcatatacgg 1079161 caagcgccaa aagggtcaaa agcgctgctg cgacactatc caagatgtcc aatgtagagt 1079221 ttgcggaacc cgtacaggaa tacaaaagct tggcaaacga tattcagtac ccttatcaat 1079281 ggccgcttaa aaacaacggt gaaaacggcg gtgtcaaaaa tgcggatgtg aaatatgagc 1079341 ctgccaacac attgctgtcc aaacgcaagc ttaacgatac actcattgca gtagtagaca 1079401 caggcgtaga cagcacgctt gccgatttaa aaggaaaagt aagaacagat ctcggacaca 1079461 attttgtcgg acgaaataac aatgcaatgg atgatcaggg gcatgggacg catgtcgcag 1079521 gcattattgc agcccaaagc gataacggct attcaatgac tggattgaat gccaaagcaa 1079581 aaatcatccc tgtaaaagtg cttgattccg caggttccgg agatactgaa caaattgctc 1079641 tcggcatcaa atatgctgct gacaaaggag caaaggtgat taatttaagt ttaggcggag 1079701 gctacagccg cgtgcttgaa tttgctttga agtacgcagc tgacaaaaat gtcttgattg 1079761 ccgcagccag cgggaatgat ggagaaaatg ccttatctta tcctgcatct tctaaatatg 1079821 tgatgtcagt cggcgcaacg aatcgcatgg atatgaccgc tgatttctct aactatggaa 1079881 aaggtctgga catctctgct ccagggtctg atatcccgag cttagtgccg aacggaaatg 1079941 tcacgtacat gagcggaacg tctatggcga cgccatatgc tgccgccgct gcgggactgc 1080001 tgtttgctca aaatcctaag ctaaaaagaa cagaagttga ggatatgttg aaaaagacgg 1080061 cagatgatat ttcctttgaa agtgtcgatg gcggagaaga agagttgtat gacgattatg 1080121 gcgatccgat tgaaattccg aagacacctg gtgtagactg gcattcaggc tacgggcggc 1080181 tgaatgtcat gaaggctgtc agcgcagctg atttacagct taaggtcaac aagctggaaa 1080241 gcactcaaac agctgtcaga ggaagcgcga aggaaggcac ccttatcgag gtgatgaacg 1080301 gcaaaaagaa actcggcagc gccaaagccg gaaaagacaa tgcgttcaag gtgaatatcg 1080361 cgactcaaaa acaggatcaa gtactgtatc tgaaagcaac aaaaggcgat gcgaaaacat 1080421 cgtataaagt tgttgtcgtc aaaggaaaac cttccggcac accgaaagta aacgcggtga 1080481 aaacgaagga tacggcagta aaagggaagg caaacagcaa agcgatgatc agagtgaaaa 1080541 acaaatcaaa gaaagtcatt gcttctgcca aagctgacgc aaaaggaacg ttttcggtga 1080601 aaatcaaaaa acaaaaagcc ggaacggtgc tgtacgtcac ggctgtggat acagataaaa 1080661 aagaaagcaa ggaagcaaaa gttgttgttg aaaagtaacc aaaaagcggt gctcgatgca 1080721 ccgctttttt atttgcgccc ccgttggact gctgtgtaca taatggatcg ctttccgttt 1080781 gaagccgtcc attcaaaacg gtctcctgtc ccttcgctgc tgtagttgta gtgatgctgc 1080841 atcgcgcatt gtgcggtgtc atttgaaaag tgataaaagg acacaccctg ccccgccgaa 1080901 gtattcgaaa agactccttt attataagaa aagacgcaat cgaataccga taagccgaag 1080961 ctgtgcaagt gctgcagaaa tgcgagaaag gtttcgtcgt caagcgaatc caaaagcgcc 1081021 atgagcggcc gcttgactga tttctcatag cggatgcgtt ctccgccgga aagggagatg 1081081 ttttctgcac cgcatgccaa aaccaacttg tcctgaaagc cggcttgctc ccactttcct 1081141 ttatgatgga tccagattgg gctgtgttgg agactgtccg ccagcagtat atcgccttca 1081201 ccgttttcga ttaagcagat gccgtcttca atgaggatgg tgccgtattc ccactttcgt 1081261 tcctctgtat ataacaattg tttccgtttc atccatgctg tctccttttt cttcattcct 1081321 ctcttttctt tccaattcaa gcctgtccca tacaactctt ttatggacaa atcaactatc 1081381 tgcctataga tgcataaact tactaaggtg ctgaaagaaa cgaaattgtt acgaaagaaa 1081441 cgggattgga gctgatgtca catgtgtgga attacgggtt gggtcgattt taaaaagcag 1081501 ctcgtccagg aaaaacaaac gatggacaga atgacagaca ctctttccaa acgagggcct 1081561 gatgattcaa acgtttgggg ggagcaccat gttttattcg gacataaaag acttgcggtt 1081621 gttgatattg aaggcggacg ccagccgatg gcgtgtacct ataaaggcga tacgtacacc 1081681 attatttaca atggcgagct ttataacacg gaagatttgc gcaaagaatt gcgggcgcgg 1081741 ggccatcaat tcgagcgtac gtcagatacc gaggtgcttc tgcacagcta catcgagtgg 1081801 caggaagact gtgtcgacca tctcaatggc atattcgctt tcgctgtgtg ggatgaaaag 1081861 cgtaatctgt tgtttgccgc gagagaccgt ctcggtgtaa agccgttttt ttacacgaag 1081921 gaaggctctt catttctctt cgggtcggaa atcaaagcaa tcctcgcgca ccctgatata 1081981 aaagcgcgag tggacagaac gggactttct gaaattttcg gtcttggacc gtccagaacc 1082041 ccgggcactg gcatatttaa aggcataaaa gaaatccgcc cggctcacgc gctgacattt 1082101 tccaaagacg gacttaatat ttggcgttat tggaatgttg aaagcgaaaa acatacggac 1082161 agttttgatg acacggttgc caatgtcaga tcgttatttc aggacgcggt gacgcggcag 1082221 cttgtgtcgg atgtgcctgt ttgcacattc ctatcaggcg gtctggactc aagcgcgatt 1082281 acagcgattg cggcgggcca ttttgaaaag gaaggaaaag caccgcttca tacttattcg 1082341 attgattacg aagagaacga taaatatttt caagcaagcg cttttcagcc gaatgatgac 1082401 ggaccatgga ttgaaaaaat gacagaggct ttcggcacaa cgcaccacaa atgcgtcatc 1082461 agccaaaaag acctcgttga tcatttggag gaagctgtac tggtcaaaga cttgccggga 1082521 atggcagatg tcgactcatc cctgctgtgg ttttgccggg aaatcaaaaa ggactttgtc 1082581 gtcagcctat cgggagaatg cgcggatgag attttcggcg ggtacccgtg gttccatacg 1082641 gcagatgttg agtctggctt tccatggatg agatcaacgg aggagcggat caagctgctt 1082701 tctgactcat ggcagaaaaa attgaatctg aaagaatacg taaatgccaa atatgaagaa 1082761 accttggcag aaacgccatt attagacgga gaaacgggtg tggataaagc aagaagacag 1082821 ctgttctatt taaatatgct ttggtttatg acgaaccttt tggatcggaa ggatcgcatg 1082881 agcatggggg cgagcctgga agtgcgggtg ccgttcgccg atcaccggct tgtggaatat 1082941 gtttggaata ttccgtggga aatgaaaatg catgataatc gggaaaaagg cattttgcgc 1083001 aaagcgcttg agggcatttt gcctgatgac attttgtatc gcaaaaaaag cccatatccg 1083061 aaaacacatc atccggaata tacaaaaggc gtcagcgagt ggctgaaaac gatcagaagc 1083121 caaaaggact ccgtgctcca taccttactg gacagaaaac aattagatca gcttttagaa 1083181 acggaaggct cctccttcaa ggtcccgtgg ttcgggcagc tcatgaaggg gcctcagctg 1083241 atcgcccatc ttgctcaaat tcatacatgg tttgaagcgt atcgcattga tattgacgag 1083301 aggtaggttc aatacaaatg tgattaaaag ccagagatgt atagatttaa ataagaagga 1083361 tagatgagca gggaaatata tgctctatct atcctttttt gtacaacagc actatcgaat 1083421 tgcccccgca ttccttcaat aagaatgaat aggttttaat gttctgccga taaaactagc 1083481 tgataccggg cttaacttta attccctagc ccatacagaa agttgaccaa tatggtgaat 1083541 ttcgtgagcg atgatatggt gtaatatttc atctcgcgta tataaaacac ctgtctccca 1083601 aggaacgctt acaagttcat cttttatttg atctgaatgt gtttgtaaaa catcaattat 1083661 ttcagttcgg aatgtatttg agagagattt cactttattg agtgtttgat aatcagcgaa 1083721 ctgaacagcg atatcttctt ttccttggat agcacgaatc caactatatt ccacatcaat 1083781 aatatgaaaa agggtatata aaatattctc tactccgcca agacgatttt taagtaattc 1083841 ttcagtggtt agttgatgac accaagtaaa ccattgatct ctaacctgcc agttatattc 1083901 aaaaaatttc atcactaaac tcactccaat actatcatgt atcataacaa ttagcccttt 1083961 tttccgtgat tcctctatta atgaagtgat gattgagaaa tgtttacatt ctacctgttg 1084021 tatggcatta aaaataataa tgcatatctc gtcgatgatg ctgtgcgtct tgttactttt 1084081 acaaagtaag aatcggcatt ttcttcatat acaattagga aaaaacatac tagacttgaa 1084141 gaagcagtga tacataggag tgagaaaatg aaagagataa aagaagctta ccagcaatgc 1084201 ggacagattg ttggcgaata cgcgccagcc tgtttcaaag cattatcata tctcccgcta 1084261 aagcaaagac aagcctcttg ggcagtattg tcgttttgcc acacggcggc cagtgcagac 1084321 gaaaaggtat tgcccgcatt tgaagctaaa gctgatcatg tttaccaaag gacaaataac 1084381 ggtaaacaac atctatggaa ggcttttgat catgcgtatc ggacctttac attggaaagc 1084441 gaaccttttc gggagtttat tgccgcacaa aaagaagacg ccaagccgta tgatgacctt 1084501 gatgaactgc tcatgtacgc atatcggacg ggcggtgctg ccggattgat gctgctgccg 1084561 atactgacac gccgaaaaca agatcagctc aaacaagcag ccgtctctct cggcttggcc 1084621 atacagctgg ttcgcttctt aagtgatctt ggcacagatc agcaaaaaaa ccgcattccc 1084681 cgtcaggtaa tgcagcaatt cggctataca gaggctgatc tccaaaaagg caccgtaaat 1084741 aaagcgttca caatgacgtg ggagtatatc gcttttgaag cagaagccta ccttgaagag 1084801 tgtcaggatg ccttgccgct atttccgcag tattctcaaa aaacggtgaa agccgctctt 1084861 catttgcacc gggctgtttt agaaaaaatc cgggcgaagc agcacgatgt atttcaatat 1084921 cacttcgctc tcacagagac cgaagtgaag cagattctgt ctgatatcta aaaaacaccc 1084981 ggccttgatt gagccgggtg ttacgccata cctttttgaa tccagatacg tgagcgccat 1085041 cttctgtaca ttaagattcc ccggacccat tcatccgcga taaaagaaat ccaaatgccg 1085101 gcaagaccga aaccgaggtg gatgccgaaa agataagcaa gcgggaggcc aatgccccac 1085161 attgaaatca ttgccatgta aaccgggaat ttcgcatccc ccgcggcccg cagagagtta 1085221 atgataatga cattaaacga gcggcctggt tcaaggataa tggtcatggc aatcaatagg 1085281 cttgcagttg ctataatgtc agggctttgt gtgaagagtc cgatcaggtc ttttgaaaag 1085341 atcgtcatca aaacagaggt agccgcagca attccgagtg cccaatataa gctcttcatg 1085401 cagcgctcat aagcggcatc aaattgtttg ccgccgatat aacggccgat taagatttgt 1085461 gtaccctggc tgatcgcagt gccgaacagc aaaataaaca tcgtaatatt ttgcgtatac 1085521 acttttgttg tcaacgcctg cgcgcccatg atggcgataa aatacgtgac tatcatttgc 1085581 gacaggttgt atgaaagctg ctctcccgca gaaggaatgc cgattttcag cagcttgcgc 1085641 aaatgctctt tatgcatatg aaagactttt ttcagcgaca tcttcagctg gatgcgtttg 1085701 ttgacaatca caatcatcgc gattaatccg atgacgcggg cgatagatgt ggacatggcc 1085761 acaccggcaa caccgagaac aggaaagccg aacaaaccga aaatcacaac aaagtttccg 1085821 gcaatgttta aaatgttcat gccgatagtg acaaacattg tatcttttgt gtagccgtag 1085881 ctttttaaga tcgcgctgaa tgtcatgatt aaagcctgaa taaaggacag acctccgaca 1085941 acttgtaaaa agactttcgc atcaggcatc agtgcgtctg ataatcccat catatgaagc 1086001 agagggacag ccgcgaaaaa gacgacggcg ctgatggcca ggctgatgaa gaagttggcg 1086061 ccgattgaca cataagcgac ttccatggct tctttctttt gccgtgagcc tagaaattgt 1086121 gaaatgataa cggtcgttcc tgttgcgata aagctgaaca tcacgataat taaatttaaa 1086181 atctggttgc tgacgccgac tgctgccacg ctgttatccg agtattggct gagcatcagt 1086241 gtatcggcat tacccataaa catatataat gagacctcaa taaagatcgg ccaagtaagc 1086301 gaaaataatg agaacgtttt gtcagcgggt tttttcaaag cagttgattt gaagacagct 1086361 tgtttcatcg tgtctaaccc ctttcgtaaa taaaatcaac gttttaaagt gtacctccat 1086421 ttccttataa taaaaaggga tagaaacgat acttcttgta aaaatccgac ttaaaaagga 1086481 ggatgattca aatgcctcgc atcctgttta cagtcccgcc ttttccggta tttatcgcag 1086541 ctggggaagg ggtttttaaa aaaggagaaa cccatgtgaa acgtgtattc tccgtgtttg 1086601 atctgatata tgtcaaacag ggaacgttat atataacgga aaatgaaaca tcgttttctg 1086661 ttgaaggcgg cgagtacatc ttgctttctc ccggtcttga acactacggg acgaagggca 1086721 gtgatgaagc aacctcctac tattggcttc acttcgatga acatcgatat gaatttacgg 1086781 caaagggagg cagcaactgg tctgagcttc agcaggaaaa agggagcttc gaagagctgg 1086841 cccgctacgg attggccttg ccgagaaaag gcaaggtgca gcgcccgcag tttatggcgc 1086901 agcagtttga aaagctgatc gattactccg cggaaaactc tgatttgccg ctcagaaagc 1086961 aaattttatt tgaggagctg atgctgcatc ttcaaaaaga agcgttccaa ataccgtctg 1087021 cgaaagagcg ggtagcctgg gaggcggccc ggtatttaca ggagcactat aaggaaaaga 1087081 cgacaatcaa ggatctgtcg ctcgcccttc actatcatca ggattatgtg agccgctgca 1087141 tgcagcaggt gctcggcgta actccggcac aatacacgaa ccgggtgaga atgacggaag 1087201 cgaagcgtct tttatcctct acaaatgata aaatgggcgt tattgcggaa acggtcggaa 1087261 tggaagatcc gacatacttt tcaaaactct ttaagcagat agaaggcatt tcaccaattg 1087321 aataccggaa aattgtcagc cggaaagttc aataaccaga cgagggatga acatgaaaac 1087381 aacaatttac gatgtggcaa aggcggcggg tgtttcgatc acaactgtgt cccgtgtgat 1087441 aaacaatacg gggagaatca gcgataaaac acggcagaag gtcatgaatg tcatgaatga 1087501 aatggcatac acgcccaatg tccacgccgc ggcgttaacg ggaaaacgaa cgaatatgat 1087561 cgctctcgtg gcgcctgata tttcaaatcc gttttacggc gaactggcca aaagcattga 1087621 ggaaagagcg gatgagctcg gttttcaaat gttgatttgc agcaccgatt acgatccgaa 1087681 aaaagaaaca aagtattttt ctgtgctgaa acagaaaaag gtggatggca ttatttttgc 1087741 aacagggatt gaaagccatg acagtatgtc tgctttggag gaaatcgcca gtgaacaaat 1087801 tccgattgcc atgatttctc aggataagcc gcttcttccg atggatattg ttgtgataga 1087861 cgacgttcgt ggcggatatg aggctgccaa gcatcttctg tcactcggcc acacgaacat 1087921 cgcctgcatt atcggagacg ggtcaacgac aggcgaaaaa aatagaatca aaggcttccg 1087981 tcaggcgatg gaggaagcgg gcgtgcccat tgatgaatca cttatcatcc agacgcggtt 1088041 ttccttggaa agcggcaagg aagaagcggg aaaattgctc gacagaaatg ctccgactgc 1088101 tatttttgcc ttcaacgacg tattggcttg tgccgccata caagctgcga gaataagagg 1088161 cataaaagtg ccggatgatc tttctatcat tggttttgat aatacgatac tcgcagaaat 1088221 ggcggctccg cccctgacaa ccgtagccca gccgataaaa gagatggggc ggagcgtcat 1088281 cgaactgctg gcagaagcaa tagagggaaa acgaaaggcg aaacaaaaaa tagtgctccc 1088341 gcctgagctt gtagtcagac attctacatc accgctcaac acatgagccc gctaatgagc 1088401 gggttttttc attatgacag ttgaagccaa aaaaacatat tgcgtgtaaa ccaaaggcgg 1088461 tgtaaaatat aaccatcttt tgagaaagcg cttgcgcaaa atggcagagc ggatagaacc 1088521 gctgtttttt tagctgttaa gagaaaacgc tttctcaaag cgagcccgaa atgagataaa 1088581 ggagaggatg ggacgtggaa catcaagtaa gatgtgcagt attgggatta ggaaggctcg 1088641 gttattatca tgcgaaaaat ctcgtcacca gtgtgccggg ggcaaagctg gtttgtgtcg 1088701 gtgatccgtt aaaagggaga gcggagcagg ttgccagaga actcggtatc gaaaaatggt 1088761 cagaggaccc gtatgaagtg ttagaagatc ccggcattga tgctgtcatt atcgtaacgc 1088821 cgacaagcac acatggtgat atgatcatca aagcagccga gaacggcaaa cagatctttg 1088881 ttgaaaaacc gctgacatta agccttgagg aatcaaaagc agcttctgaa aaagttaagg 1088941 agacaggtgt catctgccaa gtcggcttta tgagacggtt cgatcccgca tacgcagatg 1089001 ccaaacggcg gatcgacgct ggagaaatcg gcaaacctat ctattataaa ggctttacgc 1089061 gcgaccaagg cgcgcctccc gcagaattta tcaaacacag cggtggaatt tttatcgact 1089121 gttccatcca tgactatgat attgcccgtt atttgctagg ggcggaaatc acttctgttt 1089181 caggacacgg caggattctg aacaatccgt ttatggagca gtatggcgat gtggatcagg 1089241 cgctgacgta tattgaattt gactcgggcg cagcggggga cgtcgaggca agcagaacct 1089301 ctccatacgg acatgacatc cgggcggagg tgatcgggac agagggcagt attttcatag 1089361 ggacattgag acatcaacat gtgaccatcc tatcggctaa agggagcagt tttgatatca 1089421 ttccagactt tcaaactcgt tttcatgaag cctactgctt ggagcttcag catttcgccg 1089481 agtgtgtccg gaatggaaaa acaccgattg tgactgatat tgatgcgacg atcaatttag 1089541 aagtgggtat cgccgcaacc aattcctttc gaaacggcat gccggtacag ctagatgtga 1089601 agcgcgctta tacaggtatg taaaagctaa gtatgttgca tttgaggctt tccgcaaaaa 1089661 aagcaagggc attttagccc ttgctttctc ttttctcata taaatagtac atataatcag 1089721 taggtacgcc tgaatggtcc agctgtctca gcatggcggt tacgttccct ctgtggtaag 1089781 tgccgtgatt gacgacatgc aggatggtgt ctgcataggt tgattccagt gtacctagtt 1089841 tcggatgctg cattgtgaag gtctgttcta agtccgtctg gcggctgaag aaatcatgat 1089901 actgtgactc cagctcggca gcgtgctgtt taatcgctgc catattacct tgcgcggact 1089961 gtaatttgcc tgcgctgtct ataatctctt ggtaggccac tcccgaaaga acattcagcc 1090021 aaatgtagtc agccctgcac atatgaagca gcacgtcgct gacagaagga aatacgctct 1090081 ttacttcttg ataggcagtt tcctccggca ggttttcgat atgggtaaat attttcttgt 1090141 ttgcccaaga atgatagtca taaaactgtt ttgcatcagt catcagcatg cccccttttc 1090201 taagaaattc gtttttttca tctgtttctc cttcaattgc aaaagagtga caccccaaaa 1090261 tatcctgccg ctgcccacat taccgctgca gagcatttgt ttacgatcag cataagcctg 1090321 ccgctcgtat ctatcgtctg aaacaaccgg cccgctattg caaggctgat gaaccaaatc 1090381 caagacacag cgatgcaggc ggccataaag agccatttct caagccccga atattgaaga 1090441 gagctcgtgc cgatgacgcc gatcgtgtcc agaatggcat gcgggtttaa aagagaaaca 1090501 gcggccgcaa acgcagcttg cttttttggt gtgaacgtat gtttctcatt ttggcttgtg 1090561 ttcggacgga tgttccaagt cacccagccc atataaagca aaaataaaaa tccgccggcc 1090621 atcatgactg tctcaaacac aggcagctcc tgcacaatga cagacacgcc cgcaacggct 1090681 aatacaatta acaaggtatc gcagactgaa gcactgatga cagctgggag agcccgccaa 1090741 atatgctttt gcaacgcgcc ttgctgaaaa ataaacacat tctgcactcc cagcggcaaa 1090801 attaagccaa acgcgagcac aattccgtga atgattgcat tcatgctgaa aaagctcctt 1090861 tcacattttt tttcaatcat aagagagatt gtcactaaag tctccagcca tttggttggg 1090921 ttaggaacca gccaaatgta taatgtgtaa aaaagggggg catgaccttg tcgcaatggc 1090981 agccaagccg aaagtcggat gttccgctgc atcggcagat cgaacaatat atgaaagaca 1091041 agattcttca cggagagtgg gctgtaggga cgaaaatccc ctcacagaga acgctggccg 1091101 acatgtttca agtcaaccgc agcacagtca cagcagccat agatgaactc acgtctcaag 1091161 gcttgttaga gggaagaaaa ggcggcggta cgaaggttgt aaacagtact tggagcgtgc 1091221 tgacggctga gcctccgctt gattggagcg attacgtccg ttcgggcatt catcgcgcca 1091281 attcttccat cattcaagct attaatcaga acgaaccaag agcggatatc atcagattag 1091341 gaactggaga actttcaccg gatcttgtgc ctgctgacac aattggacgg atgtttcagc 1091401 aaatcaatcc gggcgtcctg tctttaggat atgagcagcc gaaaggaaac cgtcagctgc 1091461 gggaggcagt ggccgaccat ttaaaaggaa agaagatcca tgtgtcaccg tctgcaattt 1091521 taattgtgtc cggtgcactt caggcacttc agctcatctc aattggactt ttaaaacgag 1091581 attctgtcat tttgacggag aagccgtcct accttcaatc cttgcatgta tttcaatcag 1091641 ctgggatgcg gcttcgcggc ttgccgatgg atgatgaagg ggtcaaagcg gggcttgttt 1091701 cttctaatcg aaaacaatat ggaggacagc tgctttacac gattccgtcg tttcataatc 1091761 cgacaggcac agtcatgtca gagcagcgaa ggaaagagat catcagcctg tcaaaaaaag 1091821 agcagatgcc catcattgag gatgatgcgt acggtgattt atggtttgaa gaaaaaccgc 1091881 cgcagccgtt gaaagcaatg gatcatgagg gcaatattct gtatctgggc gcgttttcaa 1091941 aaacggttag ccccggtctg cgaatcggct ggcttgccgg tccggagccg gttattgaaa 1092001 ggctggcgga cattaaaatg cagacagact acggatcaag cggcctgtcc cagtgggcgg 1092061 ctgccgagtg gctgtcacag ggatattatg aagagcatct gacttgggta cgcaggaagc 1092121 ttaaagaaag gagagacgcc gccgttcatt ttctcgagcg gtatgccggg gacattgcca 1092181 cgtggcggat tcccgcaggc ggcttttata tttgggtgac atttcacaaa aacctgcctg 1092241 tcagccgttt cttttatgaa ttgctgaaac ggcaggtgct tgtgaatccc ggctatattt 1092301 atgacggtga agaccgaaac agcatcaggc tgtcatattc ctatgcatct cttggagatt 1092361 tggaaactgg cattaaagcg gcagctgaaa cagcacgccg cctgatgatg tcctaggctt 1092421 tggttatacg atgacagctc ccagtgccct ggcgaaggca atcgcgtgct caggtgcgat 1092481 tttgcagcct ttcaatttgt cgagggagac atgaagctgt tcaaaacggc acgtgctgat 1092541 gtccatgttt tgaagggacg tgccggtaaa gctggcgcct tccaattcgc atccgtcaaa 1092601 gtgtgtctgc tggagcaccg tatcgctgca ttcactttgc ataagagcac agtgatcaaa 1092661 tcgaacttgt ttcatatttg agtacgaaaa tgagctgaaa tgtccgtggc attcctcgaa 1092721 tgaaacattc cgcagcgttg cttccgccac attcattcca accatttttg actgcttaac 1092781 tgaagttctg tgaatgacag ccccgctgaa atcggcgttt gataaatcgc atttttcaaa 1092841 gatcacatcg gtcagttcaa tatgccgaaa agacacatcg ataaagacga catttctgaa 1092901 taccgttttt tcaacacata gtctttcgat atcttcgccg cagatggtgc aatcttcaaa 1092961 caaatgcatg ctgattacat catcctgtgt cacggcatca tgaaaatctg cggtttgcag 1093021 gttttccggt atgttcggtt tttgaattgc gattttattc atgtgatgac atcctttgct 1093081 gcccgaaaaa cagaggcttc cgggttcaat ttaatagatc gttaaggaaa ttgatacata 1093141 tagtaaatcg tgaagagcct tttcttggta cagcagcccg cttgttttgt aagcataaat 1093201 ggaaagcttc ctatacgtca aggcgtttac aggccgaaaa agccaaaggg aacaggagga 1093261 atgcggaatg gggcattaca tcaaaaccga ggagcatgtg acactgtttg tagaggatat 1093321 cggacatgga aggccgatca tctttttgca cgggtggccg ttgaatcata agatgtttga 1093381 atatcaaatg aatgagcttc cgaaaagggg atttcgtttt atcggcgttg atttgcgggg 1093441 atatgggcaa tctgaccgcc cttgggaagg ctacgattat gacacgatgg ccgatgatgt 1093501 gaaagcagtc atttatacgc tgcagcttga gaatgcgatt cttgccggtt tttcaatggg 1093561 cggcgcaatt gcaatccgtt atatggcaag gcatgaagga gccgatgttg ataagctgat 1093621 tttactgtct gcggcggccc ccgcgtttac aaaacgcccg ggttatccgt acgggatgag 1093681 gaagcaggat attgacgata tgattgaatt gttcaaagct gatcggccca aaacactggc 1093741 tgatttaggg aaacagtttt ttgagaaaaa agtgtctcca gagcttaggc agtggtttct 1093801 caatctgatg ctggaggctt cctcctacgg gacgatccac tcgggcatcg cattaagaga 1093861 cgaagatctc agaaaggaac ttgctgcaat caaggtgccg acgctgatcc tgcacgggag 1093921 aaaggataga attgcgccgt ttgattttgc gaaagaattg aagcgcggca tcaaacagtc 1093981 ggaattggtt ccgtttgcaa acagcgggca cggagcattt tatgaggaaa aagagaagat 1094041 caacagtttg attgcgcagt tctccaactc ataagaaaaa acccgacatt gatcgggttt 1094101 tttatataat tcctctgttt tgcagtgcgt taatgatgag atcagctcca tcggaaatag 1094161 aggtctggtc agactcaatg atgaaatcgg gtgaaagcgg cgcttcatac ggagaatcga 1094221 tcccggtgaa atgtttgatc tctccgtttc gcgctttttt ataaagccct tttggatcgc 1094281 gctgttcaca aacatgcagc gggcacttca cataaatttc gaagaactca cctttaggaa 1094341 agagcgctct aaccatgtcc cgatcctctc tgaatggaga aataaaagcc gttaaaatca 1094401 tttgcccgct gtcgacaaac agcttcgcca cttctccgat ccggcggatg ttttcaatcc 1094461 tgtcaccagt ctgaaatcca agatctttgt ttaagccgtg gcggatatta tcaccgtcaa 1094521 gcacgtagct ctgaatgccc ttgcggtaaa gcttttcatc gacagcattg gccagcaccg 1094581 attttccgga gccggacaaa cctgtaaacc aaaggacgca gcttttgtgt ccgtttaagg 1094641 actgtctgtc agactttgag atggcagcgg gatgccaaat gatgttcgga ttgtgtgtca 1094701 ttgcaattcc ccgctgtttt gcttgatggc aacaggctgt tggtgaagtc ccttgatcag 1094761 cacggctgcg acctcaggcc ggctgaattc tttaggcggc tttttgcctt ggcggagaag 1094821 ctctctcact tttgtgcctg ataagtggat gtggtctctc gggctgtgcg gacatgtttt 1094881 ggaggtgccc atgtttccgc attttcggca ataaaagctg tgctcaaaaa acagcggctt 1094941 gatgcccagc tcttcctctg tgaatgattg aaaaatattt tgggcgtcgt atgttccata 1095001 gtagctgccg acacccgcgt gatcacggcc tacaataaaa tgggtacagc cgtaattttt 1095061 tcggacgagc gcatggaaaa tcgcttcccg cggacctgca taacgcatgg cggcagggaa 1095121 aaccgataac atgacacgat cctttggata atagtgatta agcaaagcct ggtagctctc 1095181 cattctgata tcgctgggga tatcgtctga ctttgtttct ccgacaagtg ggtgaagcag 1095241 cagaccgtcg accgtttcta acgctgtttt ttgaatgtat tcatgcgctc tgtgaacagg 1095301 gttcctggtt tgaaagccga caatcgtctt ccagccgagt ttttgaaagg ccgctcttgt 1095361 ttcagcgggc gttgcataaa actgttcgaa agatttgtca ggcaggctgc tgaccgtgat 1095421 aggccctccg atatagtaat ccgggcgcgc cagcaatttt tttacgcctg ggtgggcagg 1095481 atcgtttgtt ttaaaaacag acagtgcttc ttgtgtttta tcaggctggt atatatcggt 1095541 gactgtgatc atgccgtagg taacaccgtc tttcacaagc ttgacgtgat ctccggcaga 1095601 cagctgtctt gctgtttttt ctccgacagg cagcgtaatc ggcaggctcc acggcaagcc 1095661 gtttgccagc ctcatctctt tcacaacgga atgataatct ttttctccca aaaaacctgt 1095721 taacgggctg tagccgccga tcgcaataag ctccagatca ctcagtgcaa gctgatccag 1095781 ctctgcttgg cacgcgcacc cttcaaaatg gcatgcggga tcacagcggt tgattaatac 1095841 ccctccgtgg ggttcgtttc cattcaacgt gttcaacctc catttatacg tttccttgtt 1095901 ttcttttctg cacttaatga aagtttgaca tcagcgcctt aacatcattt cgattctcac 1095961 atcaagaacc tgccatccgc tattcttgat gcaggccgca ttctgttttc tcccgtccgg 1096021 cccatcttcc agccctctca tcgttcgggt ccggggaagg cagtgtacac atttcacagc 1096081 ctatgctcgg ataatgttga tcgtgcagtt tgttataagg caaattgtgc aggcggatgt 1096141 acgtccaaac gtcatcccat gtccagtgga taagcgggca aattttgatg agctcaaact 1096201 tctggtccag gtttacgtat tgaatatgct ttctcgttgg tgactgatcc cggcgcagtc 1096261 ctgaaatcca agctgtcatg ccggacaggt gctttttgag cggttcgatt ttccgcaatt 1096321 ggcagcagag gttcgggtta tgcttccaca gctctccgcc gtacttcgtc ccctgttctg 1096381 ttaagctcag ctcgggttcg agcatctgga ttgcaaatcc cggatatcgt tctttgacgg 1096441 tctcgatcag ctcatatgtt tcctgaaaat gaagcccggt atccaaaaag atgatgtgtg 1096501 cgtttttgtt gatttttgat attaagtcga gaagcaccat tccttctgcg ccaaagctgc 1096561 aggcgtacac aatcttttct ccgtacgttc ggtaagccca tttcaacaca tcgagctcat 1096621 cgatcaattg atccgttatc tgtttggaca gcatgtcgtt ccaagtgtca tatgtgatgg 1096681 tttcgttcaa tgttttcccc ccgtttgcat ctgctttttt tatctattga tcgagttata 1096741 ggcagactat tcattttttg cataaaggtt caggttttag gtgccgcgcc cgcctaaaat 1096801 gaggtgcgga accattaaga gcccggctga atatgctttt tagcaaaatg gttttatgcc 1096861 caaggagagg tagtatgccg attgccattt atcaggggca tcatcattcg cttgccccgg 1096921 cggacattaa catcgtcatt gatgtcatca gagcctttac ggtcgcccat tatgcgttta 1096981 tcggcggggc gaaagagatt ttgttggtcc ggacagctga tgaagccttt gcgctgaaag 1097041 acacctatcc ggattatgtt ttgacgggag aggaaaaggg ggtcggtatc agcggatttg 1097101 atttagataa ttctccaaaa cgtatggctg ggcagaatat gacggataaa agcctgatcc 1097161 agaaaacaac aaacggcgtc acagcagcat tgggggcgct gaacgcaaag catctgttcg 1097221 taactggatt ttccaatgcc aaaacaacgg cacagcatgt gaaaaagctc gtcgcaaacg 1097281 attgtgtcat aaacatagtg gcttcccatc catccggtga tgacgatatg gcatgtgcgg 1097341 agtatatcaa aggcatcatt gaagggacaa atgtggtaac ggctgcggag gcgattgaaa 1097401 gaataaaagg ctcttctgtt gcggagaagt tttttgactg ccgccagcca ttgtttgatt 1097461 cggaagacat cgtttactgt acaaaagaac tgacgggcga tttcgtgatg aaagtgaaac 1097521 aagatggaga agttccaacg atagagaggg tcataatatg aatgattttt cactagaatt 1097581 gccagtgaga acaaacaagc cgagagaaac cgggcagtcc attttaattg ataacggcta 1097641 tcccttgcaa tttttcaaag atgcgatagc cggagcgtcc gactatattg attttgtgaa 1097701 attcggctgg ggcacatcat tacttacgaa agatcttgaa gaaaaaatca gcacactgaa 1097761 agaacatgac attacatttt tctttggcgg cacactgttt gaaaagtacg taagccagaa 1097821 aaaagtgaat gaatttcatc ggtactgcac ctatttcggc tgtgaatata ttgagatttc 1097881 aaacggtacg ctcccgatga caaataaaga gaaagcggct tacattgccg atttttctga 1097941 tgaatttctt gtgctcagtg aggtgggcag caaggatgcg gaattagcaa gccggcaaag 1098001 ctctgaggaa tggcttgaat atatcgttga ggatatggaa gcgggcgcgg aaaaagtgat 1098061 tacagaagcc agagaaagcg gaacgggagg gatctgttcc agcagcggcg atgtcaggtt 1098121 tcaaattgtt gacgacatca tttcctcgga tattgatatc aacaggctga tttttgaagc 1098181 gcctaacaaa acgcttcagc aagggtttat tcaaaaaatc gggccgaatg tgaatcttgc 1098241 caatattcca tttcatgatg ccatcgcgtt ggaaacgctg cgtttagggc taagatccga 1098301 tacctttttt ctgtaaaata gcggctgcgg ggctctcgtc gtgaagagag cctctgccta 1098361 ttatttttta tggcggtaca taggcgtgag atagggaagt gaggtcaggc ggatgttgta 1098421 gatgaagtcg atgactcttg tcgatatcac ctggcatatg agggcttgaa tgacgatgcc 1098481 ccagtcaata atagacgcgg tgaccataaa aatgatgcaa ttcatgatga gcaggatcgt 1098541 tccaggattc ccgccgcggt agatagaaat catcagagca agggctccga atcctccgtt 1098601 cgaaatttta tatttgtata aaagtccgat tccgagtccc aataacactg cgccgcttgc 1098661 cagatcaagc cacaggttag atgtgatatc aggaaaaact gcatcaaaga tcaataccga 1098721 gacagaggtg acggtgatag aagcgagggt gccggtgaat gttctcatct ccagccattt 1098781 taaagcggta aaaagcattg atacattcac agcccacact gaaaatccgt gggggatttg 1098841 aaacagataa tgcaatagca ccgcaatacc tgctgcaccg cctgtcggaa tatcatgcgg 1098901 aaataaaaac aaggacatgc cgagtccttg tagtacgccg cctacgacaa tcataaacgt 1098961 aagttttgct ttcatcagca gttcagccat taagtcattt gctcctttat gaaaagactt 1099021 gtccgctgtt ttcattttat gaggctgtcc attatttatg tctcaaaata aagaaatggc 1099081 ccagcttaat aggctgagcc atcccacttg tagcgattga cgatctccat attgatctct 1099141 gtgccaatgc cttttccttt cgggatgtgg accattcctt ttgaaggctg caggctgacg 1099201 agatctgtaa aaggattctc catgacgtcc cactcgatcg gttcaatgtg atcgttcttc 1099261 attttagacc atgggggcag acaggcttgt gcaaataaag catagagccg tgagagcgat 1099321 ccgtcatatg catgggcgga tgctctgacg ccgaaataac gcgcgagctg gaggcagtcc 1099381 cgaaactcat caattccgtt gacatgcatg acatcgggct gaatgatatc caaacagcgc 1099441 tgtgaaagga gaggcacata ttgcgccggg cctttcatgt tttctccgcc ggcaacagga 1099501 acagacaaac ggcttcgaag catagcgtaa tcctgcggct gatcaaaggg caaaggctcc 1099561 tcaagccagc caatgttcgt ccattcggag aaatagcgct cccatttaaa agccgcagcg 1099621 gcatcgtagc tttggtttgc gtccagaatc atcgtaatgg agctgcctgc tgtatgctgc 1099681 agcgcattga tgtgccggac atcctccttg aatgaagtcc cgccaatttt gactttgatt 1099741 tgctcaaaac cttttttcaa ctgggcttca acattggaga ctgagcggct gatccattgc 1099801 ggggagtctg agtacgattg aaaagacgcg tacacaggaa tctcctctct gtatcgcccg 1099861 ccccataatt cgcaaaccga acaatccgca gctttggctg caatctctgt cagcgccatg 1099921 cttacagcgg aggccgcccg ctggtgccat ttttgaatcg tgcgcactaa tgacaggcgg 1099981 ctgccagcct gttttcctaa tagaaatggg atgatccgct tcgtaaaacc gacatggaga 1100041 gcagggagcc aatcaacgca ttctccccag ccgtctatcc cgctttcggt gataatcctg 1100101 atgagataac aagtccgata tcgtttaaac ccattggcat ctccgtatgg cttttctaat 1100161 cgatgaaata gcggaaaggt ttcaatccgt acaattttca cactgggtgc tacctttcct 1100221 cagcgggctg gagccgattg ccagccattt tagggtcttc tttttctttt gtttcttcat 1100281 tgttttgctt cacatggatg agcatcatca caagaatccc gacaacgaga gtcaatcccg 1100341 cgatgcttaa aaacatgccg ggtctggacc attgcatcag gcggccgaaa atcggaggac 1100401 cgatcgctac ccctaagaaa cgtacagagc cgtacagcga ggtgacaaat ccccgtcttt 1100461 ctttgccgac agccccggta atgaaactgt tcacacaagg aaggacaaga cctgagccta 1100521 tactgctcag tacaagaaca ctgataaaaa ggacaagatt ttcaatgaat gacagtgccg 1100581 cgtaggatac ggtcatgaac gccaatccaa gtacgatcag ctttttcatt aacgattgct 1100641 tttgcccgat tttgcttcct gttgtatagg acgtcacaca cataaccaaa agcgggatcg 1100701 ctaaaattaa gccttttttc acgccgtcgg tgtcgtatgt tttttcaaga acatctgaga 1100761 gataaaacag gatgccgaat aaagtaaaca aacaggtcgc accggctaaa taagcggtaa 1100821 acagccatct gccttcatgt ttaaagacac ttaacagccc ttttgcatat tgtccgattg 1100881 gtggcggttc tttttccttt ttcttttctt taataaaaat ccaagtcagt acgatcgaaa 1100941 tgatacaaaa cacaggaaag gcaaaaaacg cgccatacca gacaagcagg gcgatcagcg 1101001 agccaatgat cggcgatagc actttcccca tgccgtttga agcttcaaca aggccgagca 1101061 ccttgctctc ctgggcgcct ttaaacagat ctcccgtcag tgccatggca attgggccgg 1101121 ttccggctgc cccgattccc tgtaacgctc gtcctgccat gacccaagga taggcattgt 1101181 caaaaaaacc tgccgcaaac ccggctaaca aaccgccggc accatacaaa attaagcagg 1101241 gaataatgat gactttcctt gagaatcggt ctgcgagata accgacaatc ggaatcgcaa 1101301 atgctgcaat caaggaaaat actgtgatca cgagactgac ttgaaattgt gataaatgaa 1101361 gttcagattt catttttggc aaaatcggaa taagcatcga gtttcctagg gttaatatta 1101421 aagggattga accgattgcc acaatcgtca ttccgttatt ttgttttgat gattccatct 1101481 cagagcacac tccttttctt ctgcttagaa tgtccctgat ggcttcgttt attcagcgat 1101541 cagacagcaa aaaaccgaac agaagatacc tgttcgggaa aaaagagggt taaccgagag 1101601 cctgtgaaat caaagcatat aagtgtccat tttgaatagg cgcttttttc tgatagaaca 1101661 aaatcggagg ttcatcatct ttatgaaatc ccatttctat caggctgtca tgcagagacg 1101721 tgtgttcact cggtatatcg attcgcatcg gcccttgttt gccggccgcc agccttgtaa 1101781 ttatctgtgc tgcaacatct gatgatggag cgatgatagg gccgaatttc aaattggccg 1101841 gtgtctgtac agaaagtccg tagccaatga gctgtccgtc ctgatttctg gcgatgatac 1101901 attcgcatga agcagaaata agctgctgca aaaggtttga tcgatctccg ccaaaggcag 1101961 ccagatccgc cgcggttaag tcgtgaaagt cttgttctct aaaggatgtc agttcagcat 1102021 caagcttttt tgtataaggt tgaaaactgt gacagctgta ctttcgcact gaacctgccg 1102081 tatgaaaacc tgctttttca taaagcggca aaccttcttt tgtggcgcaa agcctgatgg 1102141 cggtgttttc atccgtttgg gtaatacagg cgtttaccat acgccggcca agaccgagcc 1102201 gttgatattc cttgtcaacg ataacaaggc cgatagaagt aagacggcca aacaaaaaca 1102261 agccgatgca ggaaataata tcaccgctga cattttgata accgaaaaag cgtccctgct 1102321 gaacaagcag tttcagctct tgttcgccat aatccggcca cccggcttgc ccgcaaagcc 1102381 gcaataagcc ggaaacgtgt tcttcatgaa gcttaatcag ttcatctact acgtccataa 1102441 gatcacctgc ttgttctaag tgttttgtac atgacaatat gattgccaat gccgggaatg 1102501 tcaaatggtt cgccaagttc cttccagcca agcttggcat agtagccctt gacatggtgt 1102561 cttgcgttgc accataccgc ctgaacgccg ctctccgcca gtttgtgctc cgcgtgtttg 1102621 atcagcgtgc ttccagcttt ttgatcgcga tatccctcga gcgttgccat gcctctcagc 1102681 cgatacgcag aggcttccgt taataaaggc tgactttgcg gggaaaaaga agcgatgctg 1102741 atcagcgttc catcataaaa cacgccgaga tgaaaggagc cttctgcgtg atcctcttta 1102801 tatttgcatt gttcgatgga ttgatgggga cgcagaatgc gatgccggat ttcatatgta 1102861 tcttccacgg aaatggtttt gacttcgagc ataatgttcc tcctcatgat tgtttttcta 1102921 tatcgtaaca cgaatctcgt tgaaaaagac tgcccgattc gatcaggcag tcttttggaa 1102981 attaatgcaa aaagatattt tggcgctgct catctttttg ctgaatatat gatgtgagct 1103041 cagcggttaa gtcagatctg aggaaaggcg ttatcaagta gatgccgtta aacagctcgc 1103101 atgccgtatc cagcagggag cgtgcaattg caaggccttc cgccttttgc ttttctttat 1103161 cttcaccggc atgggccatt ttttcgcgaa tcgtatcaga cagcttaatg ccgggaattt 1103221 cattatggat gaattcggca ttccggctgc ttgtcagcgg catgatgccg atatagatcg 1103281 gcgtcttcag atgttttgtt tcgttatgga tatcgacaag ctgctgctcg gaatagacag 1103341 gctgagaaac aaaataatct gcgccgcaat ctattttttt ctcaagccgt tttaccgctt 1103401 tatccagatg gcggacgtta ggattaaatg cggcggcaac tgagaaattc gttttcttgc 1103461 cgagcggttt tccagacaga gacagacctt cattgaattg tttgatcagc ctgattaaat 1103521 caaaagatgt taaatcatat acagacgtcg ccccaggaaa atccccgatt ttagaagggt 1103581 cacctgtaat agcaagcacg tcattcagcc ctaacgtatc aaggcccatt aaatgtgact 1103641 gtaagccgat aatgttacgg tcacggcacg taatatggac aagggaacgc atatcgagct 1103701 gctgcttgac aagggcgccg caggcaacat tgctgatccg cggggtcgcc aaagaattgt 1103761 cggcgagtgt cagggcatcg attcccgctt cttttaattc agcagcagcg gacagaaatt 1103821 tgtcaaagct tagttttttc ggcgggtcca gctctacgat aatagagcgt tttttcgctg 1103881 cgatctcatc caggccgggc tcggttcgct cgtgatgaac agaaatgaat tctttcgccc 1103941 gggttttgac ttctttttcc gtaatcggag ccagcccgcc aaccgcttcc gccatcgccc 1104001 tgatgtgatt cggcgttgtg ccgcagcagc cgccgataat ccgcgcacct tgcttacgga 1104061 attctgacgc gctgttttga aaatacgtgt cgtctgtttc atagacgagc cgtccctctt 1104121 caagcgaagg aagactgctg ttcggataaa cggataagaa tacgtcatca aaaatcggca 1104181 cttcgcttag cgcttcaatc atgtgataag ggccgaggcg gcagttaatg ccgacaatat 1104241 cagctccgag atccgcaatc gagcgcaatg cgtcagaaag cggcgttccg tcctgcaata 1104301 cgccttgctc gtgcatggag acattgagca taatcggaag atcagtctct ttgcgcgcga 1104361 ttttcagcac ttcacgggct tcttccaaat cataatatgt ttctaacagc aagccatccg 1104421 gctcttcatg cagcagcaga tacagctgct cgcggaagct gcgcttaatt tcgtcaagac 1104481 tgtatgcgtt tttattaaat gtgcgtatgc cgcccatcgt tccaagcacg tatgcatcgc 1104541 ctgctgaagc ccgcgcgatc tttacggcct cctgattcat ttttttgatg tcatcctcaa 1104601 gcccgtgtct ggataattta atatagttgg ctccgtacgt attcgtttga ataatgttgg 1104661 ctcccgcttc aacgtacgct ttatgtatgc gctgaatttc ctccggcttt gaaatattga 1104721 gctcctcaaa acacctgtca atgccatagg agtagaggag cgtccccatg gcgccgtcac 1104781 cgattaacac ctgtctttgc aaatcttcta aaagtcccat tgtctgcctc ctttattcac 1104841 atcagcaagg aaaaaagaga aataaaaaaa gtcctcttaa gaagaagact ttgtcagtga 1104901 ttttgtctct tcttatcttc caagctgttc gagcttgctg gatttagcac cttggtcatg 1104961 gctgatcgcc attacaccgg ttgctgaagc ttcgtcgggc cagtccctct gcttctcttg 1105021 ataagaacgg atatgaaatt ttcgtgtcag gaagtgccaa aagatatctg gcgtttttcc 1105081 ctttctccaa atttaccgaa aataaagaca ataatcaata ggaatcagaa aatttatctg 1105141 aaatttataa attgaacgtc aattggcaga tctgctcccc gtacagctga gataatctgc 1105201 tgcaggtcat ctttgttttt tccggtgaca cgcacttgat catcctgcac ctgagacttt 1105261 actttcagtc cggagttttt gatgatcgta ttgatttttt ttgcgttgtc cttgtcaatg 1105321 ccttgaacaa gctttgcacg ctggcgcacc gttccgcctg acgcgttttc aaccttgccg 1105381 taatcaatgt tttttgtcgg tacgtttcgt ttaatcaatt tgctgaccag cacatctttc 1105441 agctggctta atttgaattc gtcatcggaa acgaggacca gctcctcttt atctaaagaa 1105501 atgtcgcttt tgctgccttt aaagtcatat cgggtactga tttccttcag tgcgatttgg 1105561 attgcgtttt gcacttcagg caattccacc ttggatacaa tatcaaatga actttctttt 1105621 gccatatgaa aacctccata acatttaact tatgtgttga ttatagtaga ataaagagaa 1105681 acttccaaca gaacaaagaa tcaatttgtg atgattggaa aaaatgttaa caaaatccgc 1105741 agagaataag cggaacagga aggacgatag catgagacca gggcagcaat taaccttgag 1105801 tatagatcac caaaccgact tcggttactt tttaaccgat ggggaagata cgattctctt 1105861 acataacagt gaaatgactg aggatatcga ggacagagac gaagtagaag tctttatata 1105921 cgtagaccag caggaaaggc ttgcggccac gatgaaaatt ccgatcatca gcgcggatga 1105981 atatggctgg gttgaagtgg tggataaagt ggaagatatg ggcgttttcg ttgatgtcgg 1106041 tttatcgaag gacgcactag tcgcaactga gcatttgccg ccgtacgaag atgtctggcc 1106101 gcaaaaaggg gacaaacttt actgtatgct gaaggtgacg aaccgggggc gcatgtttgc 1106161 gaaaccagcg ccggaagata tcatcagcga actgtttacc gacgcttcag aagatctgat 1106221 gaataaagag ctgacaggta cggtgtacag gctgatcgca tcgggttcat tcgtgatcac 1106281 ggatgacggt atccgctgtt ttattcaccc gtcagaaaga aaagaggagc caagactggg 1106341 ttcaagagtc acaggccggg tgattcaagt gaaagaagac ggttcagtca acttgtcgct 1106401 gcttccgaga aaacaggatg caatgtcagt tgatgctgag tgcattctaa cgtatatgag 1106461 aatgagaaac ggtgccatgc cgtacagtga caaaagccag cctgacgata tcagagaacg 1106521 ttttaatatg agcaaagccg cctttaaacg cgcgctgggc catttgatga aaaacggaaa 1106581 agtgtatcag gaaaatggat ggacatacga gaaaaaatag catgaaaacg gctcgcctgc 1106641 agcagactgc ggagcgagcc gtttttttat gtctagttta attcatcaac cagcgttctg 1106701 attgccattt cgcgatccac attgtctgaa atcgcaatcg gcgtaatatc aatggcgaga 1106761 atgatcagaa tcagggcacc tgctgcagca acataagaaa cataatagaa atagttagcg 1106821 gtatcaacag tgttgacaag ctcggcctga actctggatg tatcatcctt agaagcggcg 1106881 atttcctttg cagcttctac tttttcttca acgatttgac ctgctttttt cagcagttca 1106941 tccactttca atgcatcttt gctgtaaaca gctttcttca ggttatcaaa aaagtcagca 1107001 tcctcttttt taatatcagc gacaacctga ttggcaaaag cctttgcctg ttttgtgttg 1107061 agtttgtctg tcatcgcttt attaaagacc tctggaagct gtttgccaac ttccccttgg 1107121 gcaaacacaa agcctttaaa aatttcctca cctgaatact caagctgctt tgcctgtgcc 1107181 acactttctt gctgcttcac caaaaacaca gtcgtcacca atacaaccga caaaaatact 1107241 agaaacgcct tcttcaaact gaaacctctc ccttcttgtg ttttttattc cacaacagtc 1107301 tgcgaatata tgtaaattga atcgtggaat cgataggagt gagatacaat atcaaaatgc 1107361 cggccatgat aatcgaaaaa ctgatgaggc ccagcatgac tgcaaaaatc tcatgcataa 1107421 aaacagcgat gatcaaaatc aatctccaat gcttcttcgg cgcaaacagt gccgcgaaga 1107481 tgacaatttg aaccagcagc gtcccccatg tcggaatcac cacgaacgga cttgttacaa 1107541 ttggcttcgt taacgcctga aaaaagccgt tgaagccaat ggttttttcc tgggcgaaat 1107601 aatagacggc cgttccgtcc acccattcct gctgagatag cttagcgacg gtagagtgaa 1107661 aataaagcac cgccacttgg attctgatca caaaataaga aataaaagct gttatttttc 1107721 caagtgttct tttgccctct ataggtctcg tactccaatg ccattttctc ggatcggtca 1107781 gcgtgatggg aagcaataaa aaggtcatga ctgctgctgc ctgctcgcct ccgtcgatga 1107841 cgatcagcga tgactgcagg ctgtaactga cataccaatg cagaaccccg gtgattctgg 1107901 ggcgccagcc aatgacaaca agcaccagaa tggcaatgca gacccatctg aaaagattta 1107961 acatcatata gttattttcg ccgagacaaa agagactgag attcatttta caagctggat 1108021 agctgctgat cccgctggct ggcttcataa tgaggctcgg gtgattgatg agcagcgtca 1108081 gcaggctgga tagcgcaatg atgcttcgcg cgaggccata tacatttgtc cacgggtttc 1108141 tttcgtccca tctggtgatg gtctgtttta tgttttcgag catgagatca caaccttgac 1108201 tatgcttttt acctgataag acgaaggggt atatttagaa tagctccaag gaacaatatc 1108261 ctctttcgtc aaatagtagc tgccacaaag cagcgggcgg ggagcgggtg tttttaattg 1108321 cacggttttg gctttgcttt tgcatgcgcc gaggtccttt tctttacatg ctgtccactg 1108381 ttccttgccg acttggctgt agatcacgcc catttcaacg ccttgtgacc gcccataccg 1108441 atacaggccg aataggttgt cagccctcat attgggccat ctgaccttgg cgctggcatt 1108501 ttcagcctca tataagccga ttgcagtatc acgcggattt ttgctaaaaa agccccagcc 1108561 ctgagggagg atgctggaca tgagaaattt ggagtccttt gtcagcggaa tcggggttgt 1108621 ccctaagctg ccaataatag aaaacagaaa tagcgaaccc caaaggattg aaaaaatgac 1108681 aaaaaatgat atcgatttct gcattcgact gctcctttta acctgaagaa tcgtttttac 1108741 acttttcata atataaaaac atttatgtaa taaaaaggtt aaaaagtatg agaaattcca 1108801 tttttgttaa aaggaaaaac aggacatttt acactgctat atgtgattga tatatagtgt 1108861 ttttttcgat atatttaaac catgaaaacg aatcaagtta atgaccgctg gattgttcaa 1108921 tttcgaaaag ggattttcga gctggccatc ctatcccttc tgcgttctaa accgatgtac 1108981 ggttatgagc tgacgtcatc cttaaaaacc acctcggcgc tggctatttc agagggagcg 1109041 atttatccga ttttgaaacg tatgaccgag aagggatgga tcgaattttt ttgggaagat 1109101 tcactggacg gcccgaaaag aaagtattac aaaatgacgc aaaaaggaga agaaatgtta 1109161 aaagaacggc tggagaaata cctggaaacc catcaagcct tactgtcttt atcgggggat 1109221 ttgctatgaa tggacagctt atcattgacc gatacatgga ggaactaaat gcagagctgg 1109281 cgaatatgcc tgatgtagag agagaaaacg ctatcgacga attaaagggg catatcaccg 1109341 ctttcgttca agacagaatc aaagccggcc ttagtgaaga ggaactgcag gaagctgttg 1109401 aatctgaatt ttctcatccg aaggagcttg ccgaattgat gatgggtgat gggggagaga 1109461 cgaaaaggag gaggtcttta ttgggcaaaa gctggatttc ggtccttctc attgtcacga 1109521 ttatcgccct gccgctgctg ccgtccgact tcagacatct gccgctggct gtttatttaa 1109581 tggtgctcgc cggatatgta tggaagcgga aaaaattggt gatgtttgca ggtgtcagaa 1109641 aaaacaaaat gcgctctcaa aaggagattg tcaagatttc gcgagtcggt gcggtttatc 1109701 tgctgttttt agcagtggtg ctccttttga gcccgttcct caatgcgctt gtcgtcctgc 1109761 tgctgattgc agtaagctgc gccgcttttt ttctttttct taacatcaag taatcttgta 1109821 ggaggctgta agatggaaat cagcatcaat tatctattaa ttgtcatcgc gcttttattc 1109881 tttgtggttg cctattttgt cggaatcaaa aaacaaacct ggatgttggc tgggtttaac 1109941 gaggcgcgta tacgggataa agatcggctg gccagaatag caggctactt tttcttgaat 1110001 tccggtttgt tcattttgct gaatagtttt atctcatttc aaggtcagga gcagctcata 1110061 cctccgctta tactggcata tggagcaggg gttattattt atgtcaataa aaaattagta 1110121 gagtagaaaa agaagggcag agcgaaatat ctctgccctt cttttttggg aaaataagaa 1110181 cgaagcacca catacaagtt tttgtatttt tgataggatg aagaaaaatg gtagattcca 1110241 aaataggaag gatgtggtgt tttgcgcaac ttgaccaaga catctctatt actggccggc 1110301 ttatgcacag cggcccaaat ggtttttgta acacatgcct cagctgaaga aagcatcgaa 1110361 tacgaccata cgtatcaaac cccttcatac atcatcgaaa agtcaccgca gaagccggta 1110421 caaaacacaa cccagaaaga atcgctattt tcctatcttg acaagcatca aacgcagttt 1110481 aagctcaaag ggaatgcgaa cagccatttt cgcgtttcga aaaccataaa ggatccaaag 1110541 acaaaacaaa cgttttttaa attaacggag gtttacaaag gaattccgat ttacggcttt 1110601 gaacaagcgg tcgcgatgaa ggaaaacaaa caagtgaaaa gtttctttgg aaaggtgcat 1110661 ccgcaaatca aggacgtctc cgtcacaccg tctatttctg agaaaaaagc aatacataca 1110721 gcaaggcgtg agctcgaggc ttccattgga aaaatcgaat atcttgatgg ggaaccaaaa 1110781 ggcgaattat atatctatcc acacgacggt gaatatgatc tcgcctacct tgtgagactc 1110841 tcgacatctg aacctgagcc tggctattgg cattatttca tcgatgccaa aaacggaaag 1110901 gtcatcgagt cctttaatgc cattcatgaa gcggcaggta caggaatcgg cgtgtcaggt 1110961 gatgaaaaaa gctttgacgt cacagaacaa aatgggcgct tttatttggc tgacgaaaca 1111021 aggggaaaag ggatcaatac atttgacgcg aagaacctga acgaaacctt gtttacgctt 1111081 ttgtctcaac tgatcgggta tacgggcaaa gaaatagtca gcggcacgtc cgtatttaat 1111141 gaacctgcgg ctgtagacgc acacgcaaat gcgcaagccg tttacgatta ttacagcaag 1111201 acatttggcc gtgattcttt tgatcaaaac ggagcaagga ttacgtctac cgtgcatgtc 1111261 ggcaaacaat ggaacaatgc tgcgtggaac ggtgtccaga tggtatacgg ggatggagac 1111321 ggttcgaaat ttaagccgct gtctggatcg ctcgacattg tcgcgcatga aatcacacac 1111381 gcagtcacac agtattccgc cggtctttta tatcaaggag aacccggtgc attaaatgag 1111441 tccatttctg acattatggg cgcgatggct gaccgtgatg attgggagat cggcgaagat 1111501 gtctatactc ctggtattgc aggagattca ttgcggtcat tggaggaccc atctaagcag 1111561 ggaaatccag atcattactc gaaccgctac acaggaacag aggattatgg cggagtccat 1111621 atcaattcgt ccattcacaa taaagcagct tatcttcttg cagaaggagg cgtgcaccac 1111681 ggtgtacagg ttgaagggat tgggcgtgaa gcaagtgaac aaatttacta tcgggcttta 1111741 acatattatg taacggcatc tacagatttc agcatgatga agcaagcggc gattgaagct 1111801 gccaatgatt tatacggtga aggctcgaag caatcagctt cagtcgaaaa ggcgtatgag 1111861 gctgtcggca ttctatgagc aaacaaaaac agtcaggaca cagagtctga ctgtttttgt 1111921 ttgctcattt tcttaaaaag aatatcgcca atgtacctgg accggcatgc gagccgatgg 1111981 ctgaactgat tggatgcata atgatttctt tcggcttgaa cgcttcctca atcaggtgtt 1112041 tcatatccgt ggctttttct ttgttcgcgg cgtagctaat cccgacggtt tgattgctcc 1112101 aatcatcccc gcgctctttc ataagctcga tgatccgttt gaaaagtttc ttctgtccgc 1112161 gaattttttc cagaggcaca agcttgccgt cctccatctg aagcagcggt ttaatattca 1112221 acaggccgcc gacaaaagcg gacgttttgg atatccggcc gcccctcgcg agatatgtta 1112281 aatcatcaac ggtaaaaatg tgttcaagct ggctgcaaaa gttctttaca gacgtttcaa 1112341 tttcttgtat tgtattcccg ttgatacaga gatcggcagc atgccggaca gccagaccgt 1112401 atcctaatga agcgcatttg gaatcaatga cccgcaaatc gaaatcgggg aattcctcct 1112461 tcacttcatt ggcgatcatt acagctgtct gatacgtgcc ggagagacct gaggaaaagg 1112521 caatgtaaag agcgggatca cctgtttcgg catattgcaa aaacacattt ttaatcgttt 1112581 gcggtgaggc ttgggacgtc ttaggcgttt ctccattttg catcgcttca aatatttgat 1112641 ccgcatgaat tgtgactgca tcttcgaatt ctttatcgcc gagagaaacc ctgagcggaa 1112701 taaagccaat gcctttttct tcaaaataag aacgaggcaa atcagtggcg ctgtcagcga 1112761 tgagatgaac tgtcatattg cttcccttct ttccgttatc gctcgttatc atgagagtta 1112821 agccaactat atcatattaa tttgccaaaa tcgtgttcaa atatttgttt taagggaaaa 1112881 cataataaag aagaaagagc ggaggaacat gccatggtac tagatcaaac aaaaaaatta 1112941 ctcatcgtca tcatcggcgc tttactcaat gctgccgggc tgaacttatt tttgatacct 1113001 gcagatgtat atgccagcgg atttacaggt gttgcccagc ttttatcaag cgtcgttgat 1113061 caatatgccc ccttttacat atcgacggga acgctcttgt tcctcttaaa cattccggtc 1113121 ggtattttag gatggctgaa ggtcggcaaa tcgtttacag tgtacagcat tttaagtgtc 1113181 gcactcacta ctctgtttat ggggatcctg ccggaaacaa gcctgtcaca tgacattttg 1113241 ctgaacgcgg tgttcggcgg cgtcatttcc gcagtcggta tcggcttaac attaaaatac 1113301 ggagcttcga caggcgggct tgatatcgtc gccatggtac ttgcaaagtg gaaggataaa 1113361 cccgtcggca cgtatttctt cattctgaac gggattatca tcttgacggc aggattattg 1113421 caaggttggg agaaagcatt atataccctg gttacactat atgtgacaac gagggtgatc 1113481 gacgccattc acactcgcca catgaagctt acggcaatga ttgtgacgaa aaaagcggac 1113541 gaaatcaagg aagccattta cggaaaaatg gtgcgcggca tcacaactgt tccggcaaaa 1113601 ggagcattta cgaacgaaca gaaagaaatg atgattatcg tcatcacgag gtatgaactg 1113661 tacgatttag aaaagatcgt caaagaagtt gatccaaaag catttacgaa catcgttcaa 1113721 acgacaggga tttttggttt ctttagaaaa gactgacgaa agcaggtgga agtcgtgaaa 1113781 cggctgcttg tgatgctcct ccccgtgctg cttttgatag gctgcgggaa agatgagcag 1113841 acagaacccg ataaggaggt atcaggcgga atggagaatc aagaggttgt tttatctatt 1113901 gacgcaattc aggagcctga acaaatcaag tttaacatgt cgctgaagaa ccaaagcgaa 1113961 cgtgctattg agtttcaatt cagcacaggg caaaaatttg aacttgtcgt gtatgattct 1114021 gagcacaaag aaagataccg ttattcgaaa gaaaaaatgt ttacgcaggc ttttcaaaac 1114081 ctgacgcttg aatctggaga aacatatgat ttctctgatg tgtggaagga agtccctgag 1114141 cccggaacct atgaggtaaa ggtgacattt aagggcaggg cggaaaatct caagcaggtt 1114201 caggctgttc agcagtttga agtcaaataa gaggctatgg cgagtcgcca tagccttttt 1114261 ttattgcagt ttgtccagct gattttgaaa ttgatgcaac tgttgacgtt ccgcatctgt 1114321 cgaattggca tacgcagaag atacagcatt tttggctctc agaatcgctt gctcctgatc 1114381 gccttcctca aagccgtttg tcaccatgac cgcctgttga acaaatgatt ttgcctgctg 1114441 aaacagttca tttctcattt aatattcata ctgcctttca gccgagtctc gtgccgcggc 1114501 atgctggtga gcttcttcta aagtagaccg atatggaaat cttgcggcgt gtagcccgat 1114561 ggagtcttta ccctgctgaa taaaccttct ggatttgctt cgtttaccca ttttgagact 1114621 gcccccttcc atactttgac gagatgagtc gtcttcaata gtatggtggg gtaaagtaag 1114681 gtttatgagt gggaaaaatt aatacggacc ttctttaaag tgagaaatat tctttcaaaa 1114741 accttgccac gccgtcctct tcatttgtgg ccgtagttcg gttggcaatc tgcttgaccg 1114801 cgtcaattcc atttcccatt gcaacgccgc agcctgcaaa ttcaagcatt tccaaatcgt 1114861 tatcctcatc tccaaaagca atgatccgct ccctcggcac gccgtaataa tcgctgattt 1114921 tctgcaggcc gaccgcttta ttcatgccgc ttttgataat ttcaatgaca tgccaaggag 1114981 cggcccatct tctatggtcg atcacctcgg catgcacatc cgataaatat gagcgtattg 1115041 ccggcacatc ctcttccttt gcatgtatga gtacggacgt cacatcttca ccgagatttt 1115101 cccgcaagtc tccgaccgtt acatttgttg tgttcatgtt aaaggcatct atcaggtgct 1115161 catcatggta atgaaagtat acgtcgtcaa tcacttcagc aagcacgtta tgtacgttgt 1115221 agctctcgct gatatccacg agctgtttga caacatcaag cggcagtgac gtatgatacc 1115281 gtccccagct gtcgtcttgc ggatgatgga caaatgctcc gttaaaattg acaattggcg 1115341 ttgtcagctc catctgctgg tagtacatgg aacttgaacg atacggacgg cctgttgaga 1115401 tgcagacata atgcccgtca tcttttaggc gctgtatcgt atgaagggtg ttttcagata 1115461 tggttttatc atcctttaat aatgttccat ctaaatctaa tgcgattaaa tagggttttg 1115521 tctccatgaa aagctccttt aaccttagat tttgcttgtt ttgccttact tacagtgtag 1115581 ctttttacca tctttattgt ctacatgtta cacttatgat tatggttatc ctaaggaggg 1115641 gcacattgtg atacaaattg agaatcaaac cgtttccggt attccgtttt tacatattgt 1115701 aaaggaagag aacaggcacc gcgctgttcc tctcgtgatc tttatacatg gttttacaag 1115761 cgcgaaggaa cacaaccttc atattgctta tctgcttgcg gagaagggtt ttagagccgt 1115821 tctgccggag gctttgcacc atggggaacg gggagaagaa atggctgttg aagagctggc 1115881 ggggcatttt tgggatatcg tcctcaacga gattgaagag atcggcgtac ttaaaaacca 1115941 ttttgaaaaa gagggcctga tagacggcgg ccgcatcggt ctcgcaggca cgtcaatggg 1116001 cggcatcaca acgcttggcg ctttgactgc atatgattgg ataaaagccg gcgtcagcct 1116061 gatgggaagc ccgaattacg tggagctgtt tcagcagcag attgaccata ttcaatctca 1116121 gggcattgaa atcgatgtgc cggaagagaa ggtacagcag ctgatgaaac gtctcgagtt 1116181 gcgggatctc agccttcagc cggagaaact gcaacagcgc ccgcttttat tttggcacgg 1116241 cgcaaaagat aaagttgtgc cttacgcgcc gacccggaaa ttttatgaca cgattaaatc 1116301 ccattacagc gagcagccgg aacgcctgca atttatcgga gatgaaaacg ctgaccataa 1116361 agtcccgcgg gcagctgtgt taaaaacgat tgaatggttt gaaacgtact tataaagcac 1116421 taagttatta acaagagctg aatttacgtt atactgtaga aaaaaggagt gagggaacgt 1116481 ggaagaagca ttaaaagaaa acatcatggg cgccctggaa caggttgtcg atcctgagct 1116541 tggcgttgat atcgtgaacc tcggcttggt atatgacgtt gatatggatg aagatggctt 1116601 gacgcacatc accatgacgc taacatcaat gggatgccct ttagcgccga ttatcgtgga 1116661 tgaggtgaaa aaagcattag cggaccttcc tgaagtgaaa gacacagagg ttcacattgt 1116721 atggaatccg ccttggacta gggataaaat gtccagatac gcaaaaattg cgcttggcat 1116781 tcaataaaac aaaaaaggac agcctgacat gtgaggctgt ccttttttac agctgaaagg 1116841 agtgaaagga aatgatgtac ctgctggcag ttttatgccc gccgcttgct gttttgtttt 1116901 cgggaaaacc gtttcaggcc ttgctgaatc tcatattgac ctgtatcttt tggctgccgg 1116961 gcgcgattca cgcctgcttt atcgtcgccg accgccgtgc cgaaaaacgg gcaagaagat 1117021 aatttggaaa aatgaggacg cagtcatggt ataatggtca taaaaacagc agggagagca 1117081 ctatgaaaaa gaaattgctt gcattcgcgc tttgtactgg cgcgtatgcg gccctgtttg 1117141 cgtactctgt gaactcagag caaaaaacag ccacaagcga gatgacggat gtcagccgcc 1117201 tgatgcctgt aaaaataaag cagacagtga aagggcagga agaggaaatg ctcattgaca 1117261 cagtcaaaga ggcaaatcga aaaaacataa aaatttcaat cgccggggcc cagcactcca 1117321 tgggcggcca tacatattat gaggacggca tcgttctcga catgacgggc tacaacaaaa 1117381 tcctgtcact cgatcaagag aagaaaacca tcagggtgca aagcggtgca acgtggaatg 1117441 atatccagaa atacgtgaat ccatacggac tcgcggtaaa agtcatgcag tcacaaaaca 1117501 tttttacaat cggcggatct ctcagcgcaa atgcacacgg acgtgatatt cgctacggct 1117561 cgctaattga tacagtcaaa tcattccggc ttttaaaagc tgacgggatg attatcactg 1117621 tcactccaaa agatgatttg tttacggcgg tcatcggagg gtacggcctt tttggcgtga 1117681 ttcttgatgt aacgcttgag ctgacagatg atgagctgta tgtcatgaag acagaaaaaa 1117741 tgaattacag cacatactca gactattttt caaagcatgt aaaaggaaat ccagatgtcc 1117801 gaatgcatct ggcgcgaatt tcaacagcga aaaaaggatt tctgaaagac atgtatgtca 1117861 cgaattacgt attggctaat catcaggatc agctgtcctc atacagcgaa cttaaagaag 1117921 acgagtatac gggagccaca aagtttgcac tcggcttgtc aagacggtat gaatggggga 1117981 ggaattggct gtgggacaca cagcaatcct atttcctgag ccagaacggc acagagattt 1118041 cacgcaataa cgtcatgcgg tccgaatcaa agtttcttga gtatgaaaac aatgacaaca 1118101 cagatgtttt gcaagaatac tttgtgcccg tgaaggagta tgggtcctat attgatgacc 1118161 tgagacaaac gctgtcggac gaagatctga acctgctgaa cattacgatc cgctacgtgc 1118221 agaaaaatga aaaggccgac ctttcctatg cgaaggacga tatgttttcg ctcgtactat 1118281 taataaacga gggcttttca aaagaagacc aggcagatac cgcccgaatc atcaggcgca 1118341 tgacagacgt tgccatcaag cacggcggca gctattatct gccttatatg acctaccaga 1118401 caaaagcgca aatgagacag gcatatccga aaagtgaagc gttttttcag aaaaaacgaa 1118461 cctatgaccc ggatgagcgc tttatgaatt acttttatca gaggtataaa taatggggaa 1118521 aaacaaatta aaatggctga cattatcaca aagcagcgtg tttttcgcaa gcagcttaat 1118581 ctttccgttt tatattctgt ttgtgaaaaa tatcggctca agctacacac agttcggttt 1118641 ttcctacgga ttgttcgggt tgagcggagc gcttatttac ccgctcctcg gacggctgtc 1118701 tgaaaggttt gacagccgtt attttctgct tctgaactcg tgggggatgg ctgttctgct 1118761 tttatatgtc ccgcatatcg gaagcgtcgt tcaagtgtat atcgtccaag tgctgttagg 1118821 gctctttgga gcgatgcaaa agcatggaga aaaagtgctg atcgctaatt ttacagacag 1118881 tggagagcgt ggaaagaaga tcgggaatta ccatttttgg acagctgtct tttcagcagc 1118941 agccattatg ctcgggggct ttctcgctga ctttttcaca gtgcaaatga ttttttatgc 1119001 aagctctatt ctatattttt tgagtggatt gatgatgatg aaaacaggct gacgcggtca 1119061 gcctgttttt ttatgcggct gaaatgcggc accgcatcaa cgtttttgtg ctggagtcgt 1119121 gctgattttt tttgagcgga attcccattg aacagaaaat ttataaatga ataaaaatat 1119181 taaatatacg attgaattaa tttttattca tgttataatg ttaaataatt tcacaaagac 1119241 caagagggtg aacttgtttt gaaaatagga attgtaggtg ctacaggata tggaggcacc 1119301 gaacttgtca ggattctttc gcatcatcct catgcagagg aatgcatact ttattcatcc 1119361 agcggagaag ggaatgtcta tagcgagggt tatcctcatc ttaccggctt agcggatcag 1119421 cagctgaagc cgattgatat gaatacgatc aaacacgaaa tagatatcat gtttctcgct 1119481 gcgccgcccg gagtatcaag tgaattgact ccaaagctgg cagacgcggg aattacggtt 1119541 attgatctgt caggtgatct gaggataaaa gaaccggctg aatatgaaaa atggtataaa 1119601 cggacagcgg caccgaaggc ggtgattcaa gaggcggtat acggtctggc agaactgaat 1119661 caactgcaaa ttcaacaggc gaaactcatt gccaatccag gctgttttcc aacagctgtt 1119721 ttgcttggcc tcgcgccatt ggctcaaaag aaactgctcg atgaatcttt cgttatcgtt 1119781 gacgcgaaga ccggtgtttc cggagcggga agaaaagcat ccatgggaac tcatttttct 1119841 gagctgaacg acaattttaa aatttataaa gtcaatgaac atcagcacac gccggaaatt 1119901 gagcaggcgc tgaatgaatg gcagccaggt ctcgggccca ttacattttc ggctcacttg 1119961 gttccgatga caaggggcat catggcgacg atgtatacca gattaacctg tgacctaacc 1120021 gcagatgacc tgcatgattt atattcggaa ttttaccaag attcatattt tgtgagagtg 1120081 aggccaaaag gtcagtaccc gcaaacgaaa gaagtgtacg gcagcaattt ctgtgatatc 1120141 gccgtgaccc tcgatgagag aacgaacaga gtcacgatcg tctcggtaat cgataattta 1120201 atgaagggtg ccgccggtca ggcagtgcaa aactttaatt tgatgaatgg ctggaatgaa 1120261 gaaactggac tcaccatcac gccaatttat ccatagaacg ggagagaatc gaaccatgat 1120321 tcagttaagt gaagatcaaa ttgtaaaagt aacaggtgat gtatcctcgc caaaagggtt 1120381 tcaggcaaag ggtgtgcatt gcggactgcg ctactcgaaa aaagacctcg gcgtcattat 1120441 cagcgagaca ccggccgtga gtgcagcagt ttatacccaa agccactttc aggctgctcc 1120501 gatcaaagtg acacaagaca gcttaaagca cggaccgaca ctgaaagccg tcatcgtcaa 1120561 cagcgccatt gccaacgcct gcacgggaga acagggctta aaggacgcat acacaatgcg 1120621 ggagagcttt gcttcacagc ttggcattga gccggagctt gtcgctgttt catcaacggg 1120681 tgtcatcggc gagcatttag acatggaaaa aatccacgcg gggatcgaac tgctgaaaga 1120741 aacacctgcg ggatcaggcg attttgagga agcgatttta acaactgata cggtgatcaa 1120801 gcagacgtgc tatgaactgg caatcggcgg caaaacagtc acgatcggcg gagcggccaa 1120861 aggctctggg atgatacacc cgaacatggc cacgatgctg ggatttgtga caactgacgc 1120921 ggcaatcgaa gaaaaagcgc tgcaaaaggc gcttcgggaa atcactgacg tttcatttaa 1120981 ccaaatcaca gttgacggag aaacatccac gaacgacatg gtattagtta tggcgaatgg 1121041 ctgcgccgaa aacgagtgcc tgacagaaga ccatccagac tggccggtct ttaaaaaagc 1121101 gctcttgctc acttgtgagg atctagctaa agagattgcc agagacggag aaggcgcgac 1121161 aaaactaatt gaagcccaag tacagggagc gaaaaacaat cttgatgcaa acgtcattgc 1121221 caaaaagatt gtcggctcaa atcttgtaaa aacggcagta tacggaacag atgccaactg 1121281 ggggcggatc atcggagcca tcggacactc cgcagcacag gtgacggcag aagaagtaga 1121341 ggtttatctt ggcggccaat gcctgtttaa gaataacgaa cctcagccat tctctgaatc 1121401 tatcgccaag gaataccttg aaggagatga aatcaccatt gtcatcaaga tggctgaagg 1121461 ggacggaaac gggagagcgt ggggctgtga cctgacctat gactatatca aaattaacgc 1121521 gagctatcgc acgtaataaa ggggagcgaa atgaagaaaa caatcgtttt taaatgcggg 1121581 ggaagcgtca tccgtgagct gtcggaggaa ttttatcaaa atctgaaaga gctgagggcg 1121641 tcaggctgga agctggcaat cgtacatggc gggggaccgg aaatcacaaa tatgctgaaa 1121701 cggttaaata tcaagacaga gttttcgggc ggacagagga aaacaacgaa gccggtgctg 1121761 gaagtggcgg aaatggtttt atccggttct gtcaataaat ttttcgttgc tgagcttgcc 1121821 aaacacggac tgcgagccgc gggcatttct ggtaaggatg gcggtctttt ggaggctgat 1121881 tatctagatc cggaaacata cggagaagtg ggagaaatca aaaaagtcga tgcgtccatg 1121941 gtgaacgcgc tgatggaaaa tggcatcatc cccgttattg cgccgctgtc tatgacaagc 1122001 gactgcaaaa cgctgaatgt aaatgctgat ctggctgctt cagcagtcgc cggagcgctt 1122061 gaagccgata agctgatgtt cgtcacggat gtcgatggaa tcatgaagga aaagcagcgt 1122121 ctggacgtcc tgacccctaa ggagattcag atgctgatca agcaggaagt gatcacagga 1122181 gggatgatcc cgaaggtcaa ttcagccttg tcagctttat cagatcaggt gtctgaagtc 1122241 atgatcgtaa acggtaaagg atcattcttc gcagaacaaa cctttcaagg gacaaaaatt 1122301 gtcaaagcaa aggaggctgt ttcatgagca gcttgtttca aacctacggc cgttgggata 1122361 ttgacatcaa aaaagcaaag ggaacgtacg ttgaggatca aaacggcaaa acgtaccttg 1122421 atttcattca ggggattgcg gtatcaaatc taggacactg ccatgaagcg gtgacagagg 1122481 cagtcaaaaa acagcttgac agcgtatggc acgtatccaa cctgtttcaa aacagtctcc 1122541 aagagcaagc ggcgcagaag ctggcagcgc atagtgcggg agatcttgtc tttttctgca 1122601 acagcggcgc ggaggcgaat gaaggtgcga taaagcttgc cagaaaagca actggaaaaa 1122661 caaaaatcat cacttttctt cagtcgttcc atggccgcac gtatgcaggg atggctgcga 1122721 ccggacagga taaaatcaaa acaggcttcg gcccgatgct tggaggcttt cactacctgc 1122781 catacaatga tccttctgct tttaaagctc ttggggagga aggcgatatt gccgcggtga 1122841 tgcttgaaac agtgcaggga gaaggaggag tcaatccggc gagtgctgaa tttttatcag 1122901 ccgtacagtc gttttgcaag gaaaagcaag cccttctcat tattgatgaa atccagaccg 1122961 gcatcggacg gacgggaaaa ggcttcgcat atgagcactt cggactctca ccggatatca 1123021 tcacagtcgc caaaggattg ggaaacggct ttccggtcgg cgctgtcatc ggaaagaaac 1123081 agcttggaga agcgtttacc cctggttctc acggaacgac tttcggagga aacatgctgg 1123141 cgatggctgc tgtgaatgcc acattgcaaa ttgtattcca gcctgacttt ttgcaagagg 1123201 ctgctgacaa aggggcgttt ttaaaagaac agcttgaggc agagctaaag agcccttttg 1123261 ttaaacaaat ccgaggtaaa ggattaatgc ttggaattga gtgtgatggc ccggttgctg 1123321 acattattgc tgaattgcag acattaggct tgcttgtatt gccggccggc ccgaacgtga 1123381 ttcggctgct gccgccgctc accgtgacta aggatgaaat agcagaagcc gtcagcaagc 1123441 tgaaacaggc aatcgctcat cattccgctg taaaccagtg attttttttc gatataaagg 1123501 cataaaaatt catttttata attaattatt catcaagagg tgggctgtta gatggaaggt 1123561 tatttagtgt tagaagatgg gacatcgttc agcggcgagc tggacggtca tgaaaactgc 1123621 acgggagaag ctgttttttt cacaggaatg acaggctacc aggaagtgct gacagatcca 1123681 tcatataagg gacagattat tgtatttacc tacccgctga ttggcaacta cggcataaat 1123741 gaaaaggatt ttgaaagcaa gaaaccgcaa gtaaaagccg cggttgtcta tgaggcgtgt 1123801 gatcactttt ctcattatga agcggtatac agcctcaagg agtatctaca gaaatggaat 1123861 attccgctgt taacccatgt tgatacgagg gctgtcgtga agaaaatccg ggcaaacggg 1123921 acgatgggtg cgacagtcac agcctctaaa gaaggagctg agattgccct tcaaccagag 1123981 aatgtggcag agcaggcttc cgcccaggaa atcagcacat tcggcgacgg gaataaacat 1124041 atcgctctca ttgattttgg ctataaaaag tcaatcgcat catcacttgt caaacgaggc 1124101 tgcaaggtta ccgtggtgcc ataccagcaa atggaggccg tatacaacat caaacccgat 1124161 gggctatcga acggacctgg agatccgaaa gccattcagc catatttagg aaagatcaaa 1124221 agcatcatca gccgctttcc gactctaggc atttgtctcg gacatcagct gatcgcgctc 1124281 gcgtttggag ggaatacttt taagctgcca ttcgggcaca ggggagctaa tcatccggtc 1124341 atcgaccgta agacgaaacg ggtctttatg acaagccaaa accacagcta tgtggttgat 1124401 gaacagtcga ttaatgaaga agagctcacc atcaggtttc atcatgtcaa tgatacgtca 1124461 gttgaagggc ttgcccataa aaaactgcct gtcatgagtg ttcaattcca cccggaagcc 1124521 catcccggac ctgcggaaag cgaatggatt tttgatgatt atctaaagaa tgtgatacca 1124581 gcaaggagag aaatcgcgca tgcctaaaga caccagtatt tcaagcatat tagtaattgg 1124641 ctcaggcccg atcatcatcg ggcaggcggc agaatttgat tattcaggca ctcaagggtg 1124701 catcgcgctg aaggaggagg gctaccgggt aattctcgtc aacagcaatc cggcgacaat 1124761 tatgactgat gaagccttcg ctgatgaaat ttattttgag cctctgacag cagaaagcct 1124821 gacagccatc attaagaaag aacggcctga tgggcttctt gccaatttag gcggtcagac 1124881 cgcgttgaat ttagcggtgg agcttgaaga aacgggtgtt ttaaaagagc acggcgtcaa 1124941 actcctcggc acatccgttg aaacgataca aaaaggagag gaccgggaaa aattccgttc 1125001 gttaatgaat gaattaaaac agcctgtgcc ggagagtgaa attgttgata acgaggccga 1125061 tgccctccat tttgcggaat ccatcggttt tcctgttatt atcagaccag cttacacatt 1125121 aggcggaaag ggcggaggaa tcgcccctga taaagaagcc tttacagcta tgattaagca 1125181 ggcgctatta gcaagcccga tcaatcaatg ccttgtcgaa aaaagcattg ccggctttaa 1125241 agaaattgaa tatgaagtca tgcgtgacag caataacaca tgcattaccg tctgcaatat 1125301 ggaaaatatc gatccggtcg gcgtgcatac aggtgactct atcgttgtgg cgccgtcaca 1125361 aacattgaca gacgaagact atcaaatgct gcggacagca agtctgacga tcatctcagc 1125421 acttgatgtt gtaggcggct gcaacattca attcgcgctt gatccattca gcaagcaata 1125481 ttacgtcatt gaagtgaatc cgcgtgtaag ccggtcatcg gctctcgcat ctaaagcgac 1125541 cggttatccg attgcgaaga tggccgcgaa actggcagtc ggatacactc ttgacgagct 1125601 gaaaaatccg ctcacaggct cgacttacgc aagctttgaa ccggcactgg attatgtgat 1125661 cgtcaaattt ccgcgctggc cgtttgataa attcaaaaac gcagaccgca agcttggcac 1125721 aaaaatgaaa gccaccggtg aagtgatggc gattgaacgg aatttagaag cggcgataca 1125781 aaaggcagcc gcgtcgcttg aattaaaaaa tatcgggaca caccttccag agctcagcgg 1125841 gttgtcaatt gatacgctat gggatttggc aatcactccg gatgaccgca gatttttcgt 1125901 tgtcatggag ctgttgagcc gcagcgtctc gattgatgac atccatgaaa aaacaaaaat 1125961 tgatccgttt ttccttcata cctttgacaa catcatcaaa ttggaaaacc gcctgatgga 1126021 agcagggagc gatctctctt ttgaattatt gaagaaagca aaggaaaagg gattctcaga 1126081 cgcaacgatt gcctcgctga tcagcaaaac agaagaagag gtgcgcgcgc ttcgcaagga 1126141 gatgggcatt acgccttcct ttaaaatcgt agatacatgc gcggcagagt ttgatgcgaa 1126201 aacaaactat ttttactcca catatttcgg agagaccgat ggagacatca gccgcaaaga 1126261 gaaaaaacgc gcgctcatta tcggatcagg cccgattcgg atcggccaag gcgttgaatt 1126321 tgattacagt gctgttcacg gtgtgctgac actgcaagag cttgggttcg aaaccatcat 1126381 gattaacaat aacccggaaa ctgtcagcac cgattatgaa attgcggacc gcctgtattt 1126441 tgaaccgatg acaacggagc atattgtaaa cgtggcggag caggaaaata ttgattttgc 1126501 aattgtgcaa tttggcggtc aaactgcaat caatgctgct gaagcgctcg aaaaagccgg 1126561 cattactctt cttggcacat catttcaaac gctcgacgtg ttagaggatc gggatcaatt 1126621 ttatcagctt cttgacgagc tgggattgaa gcacgcaaaa ggagaaattg cttatacaaa 1126681 agaagaagcc gcttcaaaag cgagtgagat cggctatccg gtgttaatcc gcccatctta 1126741 cgttatcggc ggaatgggca tgatcattgt tgactcgcaa gcccagcttt ctcagctgct 1126801 gaatgatgag gacagcatgc catacccgat tttaattgat cagtatgtgt ctggaaagga 1126861 agtcgaaatt gatttgattt ccgacggcga ggaagtcttt atcccgacat ataccgagca 1126921 tattgaacgg gcaggtgtcc attcagggga cagttttgcc attcttcccg gaccgtccat 1126981 cacgagcggg ctgcagcagg gcatgaaaga tgcggcacaa aaaattgccc gaaaactttc 1127041 atttaaaggc atcatgaaca ttcaatttgt gatcgacaat ggaaacatac tcgttcttga 1127101 agtgaatccg agagcgagcc gcacggttcc tgtcgtcagc aaagtaatgg gcgttccgat 1127161 gattccgctc gccacacgtc tgctggcggg agcgtcctta aaagatctaa atccggcagt 1127221 tcaaaatcat catggagttg ccgtgaagtt ccctgttttt tcttctcatg cgatccagga 1127281 tgtggatgtc aagcttggac cggaaatgaa atcaacggga gaaggcatgt gtgtcgcata 1127341 tgattctaac agcgccttga aaaaaatcta tacaagagtc tggagtcaaa aaggaagcat 1127401 ttatttgcaa aacgttccgg aagatgtgaa ggagttagca gaaaacgcag gttttacaat 1127461 acatgaagga acatttgcct catggatgga acaggaagga aactcgctcc acattaatct 1127521 gagcggttct gaagaagcac gcaaagaacg tttggaagcc atgacgcacg gcatccccgt 1127581 ctttacagaa gaagaaactg tgcgggcgtt tttacaaagc ggttcaggcc atccgcagcc 1127641 tgtatctctc aaagacctct ataaaaagga agtggcatca tgcacacagt gacgcaaacc 1127701 agtttatacg gaaaagattt attaacgtta aaggacctta gtgaagaaga tataaacgcc 1127761 ttgctcgcag aagccggtga gctgaaacaa aacaaaattc agcctatatt ccatggcaaa 1127821 accttggcga tgatttttga aaaatcatca acgcggaccc gtgtttcatt tgaagcgggc 1127881 atggcgcagc tgggcgggag cgccctcttt ctaagccaga aagatctgca gctggggcgc 1127941 ggtgagactg tcgctgatac ggcaaaagtg ctgtcaggct atgtggatgc catcatgatc 1128001 cggacctttg aacatgaaaa ggtggaggaa cttgccaaag aagctgacat tccggtgatc 1128061 aatggactta ccgataaata ccacccatgc caggcgctgg cggatctctt gacgattaag 1128121 gagataaaag ggaagcttaa aggcgtaaaa gtcgcgtaca tcggtgacgg aaataacgtg 1128181 gcgcactcct tgatgatcgg ctgcgcgaaa atgggctgtg atatctcgat cgcttcacca 1128241 aagggatatg aagtgttaga tgaagcagct gaagcggcaa agacatatgc acttcaatcc 1128301 ggctcttctg tcacgctgac agatgatccg attgaagctg taaaagacgc ggacgtgatt 1128361 tattctgatg tgtttacaag catggggcag gaagcggaag agcaagaacg tcttgctgtc 1128421 tttgcgcctt atcaggtgaa tgcggcgctg gtcagccatg ccaagcctga ctatacattt 1128481 ttacattgtc tccctgcgca tcgcgaggaa gaagtgactg cggagattat tgacgggccg 1128541 aactctgcag tgttccagca ggcggaaaac cgtcttcatg tgcaaaaagc actgctgaag 1128601 gccattttat ataaagggga atcatcaaaa aactgctgag ccaaactcag cagttttttt 1128661 gatggcaaca tattcacagc cgcttaggcg catactacag caaaaaggaa aaggaggaaa 1128721 aacagtggga cagcagcacc aattccggcc cggacagaaa gcgcctaata acggtgtcta 1128781 cgtagaaatc ggcgagacag ggagcatggt taaaaaccct caaaaggtcc atctgtcagc 1128841 aggggaaatg ttccccgaaa catcaaacca caaccggctg tggacctaca aaagaaagcc 1128901 gtgaccacta aaaaacccaa aacaataaat gttttgggtt tttggctttt taatgctggc 1128961 ttgcattttt gttcataggc atgatttctg ctaaaaccat gattaagaca tacagtacaa 1129021 cagcaatgac agatgatgtt ttgaaattat acgtaacgct gttcatgctt gcaaccaagt 1129081 agcatgccat atgtgataaa aggaacgtcc aaataaaggc aataatatat cgcacgtttc 1129141 cacctcgtcc ttctcattct attctaaaag ttatcatacc atacaaaaag cgaaggggga 1129201 atccaatttt agcagaaagt gaggtgacaa aagagtctga ttcgtcacac tttaatggta 1129261 aaatataaaa cgtcaatcag tataatagcc aaaaatgtaa aaggctagga ctttacctta 1129321 ttcgtttctt ttctatttac ataagatagc gtgagatgaa gtgtgaaagg aggcgggcaa 1129381 gcgatgggaa taacggaaag atactttcaa ctgggaacgg agcataatgt cattcatctg 1129441 ccctatcgcc cgaacggctt cggcatcttt atcttggggg acagaaccca ctttgtcgga 1129501 catgattcaa gcttttggca gcagcattat ggcagaaatc agcttctgag catgttgatg 1129561 aatgaaggat acactctttt taacagcaat ctgttcggaa ggcattgggg ggcggaaaaa 1129621 gcagtcacct atgccaaaca gctgatacat tctgtgctga agcaggaaat cctcaatccg 1129681 aagattcata ttttagcaga aggcatgggt gctctcgtgg ccgatgaact gcttcgtttt 1129741 tccccggatc atatccgctc agccgcaatg ttgaatcctt gtctcgatct tcaggcacat 1129801 tatgaatcgg aaaaagaaaa taaatttttc tataagcaat ttttgaaaga agtatcgaaa 1129861 agctacggaa tttctgaaaa agaagcggaa gcgattcgtt ataaaacaat tcaaagctac 1129921 ccgagcggcg taccggttca tatatggcag cgtatgaccg gagctccata tccctacagc 1129981 gtacatgcgg aagttttcaa ggaaaaacag caaaagcaag gctcaccggt cgacatgaca 1130041 tttcatttat ttgagcatcc aagcagaatt tatgcatcaa tttgcaaatt ctttcatagt 1130101 catgaaaaag aattatagag aatataatga caacagcctt ctcttttgcg gaggctgttt 1130161 tgttttggga aatgaaaaac cggaagggcg gcagatgcaa tggaatcaac gctgattgta 1130221 ggtgcggacg aatttttcgg cctttcatta tgtgagcgaa tgatggatga aggcatacat 1130281 gttgacgttg ttctggcgga aacagaagat aaaatgagac aaatgtactt agaagaaaga 1130341 ctcatgtggc ttgggagaaa tgaactcttt cgccagcttg aacacattgg agaccaaaat 1130401 tatgatacaa tttgtatcca gttcggaagt tttttgcctt tagaccaata tgattctcct 1130461 tatattttag tatatgaaga agaccgaaaa gaatgggata aacgtgaaaa aacaggctcg 1130521 gaaaaaaccg tgatcctgcc gaaaatgtac gggccatgga aagaagaaac agaggaagac 1130581 ggctattaca caaacgacgt ggctgacgag ttgctgagat tcctgttaga accaagccgt 1130641 catagcaaag atcagctttt tgaattgcaa gtcacagaga aaacctcaaa agaagaagca 1130701 aaaacaaaaa ttatcgagtg gaaaagacaa ttttcatcaa ttttcgacaa atattaagaa 1130761 aaaccttcca tgtttcgagt tttctagata caataaacgt ataaaaataa tacatgttat 1130821 agcttgtcaa aaggagttga acatgacttg atcacaaggc ttgtcatgat cttttctgtc 1130881 ctccttttat tgagtggatg tggacaaact ccgttcaaag gaaaaattga gaaggtcggc 1130941 atgctctttc ctgatacgat taatgacctc gtatggggca caaaagggta taaaggatta 1131001 ctgaatatac aatccaaata caatgtggac gtctattata aagaaggcgt taaaacagaa 1131061 gaagatatca taaatgcgat tgaggatttt cataagaggg gcgtcaatct gctctacggc 1131121 catgggagtg aatatgctga ggtgtttaac ttggtcggcg aagattatcc agatatggaa 1131181 ttcgtcattt ccaatgcgaa agcgaaagct gataatgtaa caagtgtcca ttttagcggg 1131241 gaagcaatgg gcttttttgg aggaatgact gctgcccata tgtcgaaaac gaatcaggtc 1131301 ggtgtaattg cttcctttac gtggcagcct gaggttgacg gttttatcaa aggggccaag 1131361 tatgaaaatc cggatataga ggtaaatacg aaatatacgg atcattggga tgatgataca 1131421 acagcagtaa agctttatca gaaaatgaag aacgaaggcg cggatgttgt gtatcccgcc 1131481 ggagacgggt ataatgttcc tgttattcag caaatcaaaa aagacggtct ttatgccata 1131541 ggctacgtca cagatcaatc ggatctgggc gagaataccg tattaaccag cacggtgcaa 1131601 aatgtggaca aggcctatga aatcattgct gaacaattta ataaaggcac ccttgagggc 1131661 ggcgatcatt actacgacct gaacacggga gtcgttgaga tgggaacatt cagcccgctc 1131721 gtcgatcaag actttcagca aagaatcgcc aagctgatca aaacatacaa caaaacaggc 1131781 gagctgccaa aaaacgagta atggagtgac gtcacatgca gcacgaaaaa tcacttgaat 1131841 tcttgcaaat tgccatgaaa tatctccctg aagcgaaaga acagcttgag aaatcaggca 1131901 ttgagctctc aatggaggcc atccagccgt ttatgaatct atttacaacg gtaatggcgg 1131961 aagcttatga gcttggcaag tctgacgcta aatctgaaac agaataagaa gaagccactt 1132021 ttttgaaagt ggcttttcac atgattttct ttttaatagc ggagagcatg ggcgcaagct 1132081 cctttaaagc gggcttgatt tgatcaagag agttcataat tgaaccgatt tggtccataa 1132141 tatgcatgta attaatcgtc tcttcgtcgt ttgtctgaga aacctgagaa acttcctctt 1132201 gctgttcctc ctccttctct tctgttggtt ttgctgcatc gccgaacatc attcttgaaa 1132261 acacatccaa ctgcatacgc ctcctttcca tataccatac tctatgagta agatgaactg 1132321 atagtttaga cgaatatatt gccatgtgaa aaaaaatagg atagaattag tacctgatac 1132381 taataattga tcacaacctg attgatcttc taaatttaag atataaagga gtcttcccta 1132441 atgaaagctg gaatacttgg tgttggacgt tacattcctg agaaggtttt aacaaatcat 1132501 gatcttgaaa aaatggttga aacttctgac gagtggattc gtacaagaac aggaatagaa 1132561 gaaagaagaa tcgcagcaga tgatgtgttt tcatcacata tggctgttgc agcagcgaaa 1132621 aatgcgctgg aacaagctga agtggctgct gaggatctgg atatgatctt ggttgcaact 1132681 gttacacctg atcagtcatt ccctacggtc tcttgtatga ttcaagaaca actcggcgcg 1132741 aagaaagcgt gtgctatgga tatcagcgcg gcttgtgcgg gcttcatgta cggggttgta 1132801 accggtaaac aatttattga atccggaacc tacaagcatg ttctagttgt tggtgtagag 1132861 aagctctcaa gcattaccga ctgggaagac cgcaatacag ccgttctgtt tggagacgga 1132921 gcaggcgctg cggtagtcgg gccagtcagt gatgacagag gaatcctttc atttgaacta 1132981 ggagccgacg gcacaggcgg tcagcacttg tatctgaatg aaaaacgaca tacaatcatg 1133041 aatggacgag aagttttcaa atttgcagtc cgccaaatgg gagaatcatg cgtaaatgtc 1133101 attgaaaaag ccggactttc aaaagaggat gtcgactttt tgattccgca tcaggcgaac 1133161 atccgtatca tggaagctgc tcgcgagcgt ttagagcttc ctgtcgaaaa gatgtctaaa 1133221 actgttcata aatatggaaa tacttctgcc gcatccattc cgatctctct tgtagaagaa 1133281 ttggaagccg gtaaaatcaa agacggcgat gtggtcgtta tggtagggtt cggcggagga 1133341 ctaacatggg gcgccattgc aatccgctgg ggccgataaa aaaaggtgag gtgcacacaa 1133401 gatgactaaa aaaagagtag ttgttacagg acttggagca ttatctccac ttggcaacga 1133461 cgtcgataca agttggaata acgcaatcaa cggtgtgtcc ggaatcggtc cgatcactcg 1133521 tgttgacgct gaagaatatc cggcaaaagt tgccgctgaa ttaaaagatt ttaatgttga 1133581 agattatatg gataaaaaag aagccagaaa aatggaccgc tttacacaat atgcggttgt 1133641 ggctgcgaaa atggcggttg aagatgcaga tcttaacatt accgatgaga tcgcgccgag 1133701 agtcggtgtt tgggtaggct ccggtatcgg aggacttgaa acactagagt ctcaatttga 1133761 aatcttctta acaaaaggcc caagacgggt aagcccgttt ttcgtgccaa tgatgattcc 1133821 tgacatggcg acaggccaga tttctattgc attaggagca aaaggggtga actcttgtac 1133881 ggttacagca tgtgctacag gaacgaactc catcggtgac gcgtttaagg ttattcagcg 1133941 cggtgatgca gacgtgatgg tcacaggcgg aacagaagcg ccgctgacaa gaatgtcatt 1134001 cgccggcttt agtgccaaca aagcgctgtc tactaatcca gatccgaaaa cagcgagccg 1134061 cccgtttgat aaaaaccgtg atggctttgt catgggggaa ggtgcaggga ttatcgttct 1134121 tgaagaactt gagcatgccc tggcccgcgg cgctaaaatt tacggagaaa ttgtcggcta 1134181 cggctcaacc ggagacgctt atcatatcac agcgccggcc caagacggtg aaggcggagc 1134241 gagagcgatg caagaagcca ttaaagatgc aggcattgca cctgaagaaa ttgattacat 1134301 caatgctcac gggacaagca cgtattacaa cgacaaatac gaaacaatgg cgattaagac 1134361 cgtttttggc gagcatgcgc ataaacttgc ggtaagctct acaaaatcga tgacaggcca 1134421 cctcttagga gcagccggcg gtattgaagc cattttctct atcctggcca ttaaagaagg 1134481 cgtgattccg ccgacaatca atattcaaac acctgacgaa gaatgtgatt tggattatgt 1134541 gcctgatgaa gcccgcagac aggaacttaa ttatgttctc agcaactcat taggattcgg 1134601 cggacacaac gcaacattaa tctttaaaaa atatcaatca taatcaagcc aaaccggctg 1134661 cccttaaagg gtagccggtt ttttttgtgt gcataggatt aaaagaggag gcgatcacat 1134721 gagtgtagaa caaacatata gctggctcag gaaggccggt tcaatagatg atttggcgca 1134781 ttacattatc ccgctttttt caggtgcgga gaaaaagaac tggaagggca ttctggggca 1134841 tcttcagcat catgggatgt ttaaaaacat aaaagagggt attcagacgg tttccaagct 1134901 gaaggaaaaa ggtttttacg gacatatcca aaaggaagaa cagtacctca aaaacaaatg 1134961 gcaaggtcct gatgtaccaa ttgttacgct gccggttgat gaacgaaaca ggagaatccg 1135021 tttagaattc ggatcaaaat caggactcgc ctttcaagac aaaatgttcc tttttctttc 1135081 gtcagattta gattttgggt cggtatctgc ccttatgacg catgagtatc atcacgtttg 1135141 ccggttaggt catctgacaa aagaggaaaa ggatgtcaca ttacttgata caatcatcat 1135201 ggaagggctg gcggaatatg ctgtttatga gaggttcggc cgaagtcaaa cggctgaatg 1135261 gacgacttgg tatacaccgg aacagcttca ggctttatat gaaaaaaaga ttgcgcccca 1135321 tcgggatatc aaacgggata atcgattatt tccccagctg ttattcggca aaggatatca 1135381 gccaaaaatg cttggatacg cagttggatt caatattgta aaaaaatatt taaccgccag 1135441 caaggcaagc accgcagacg ggctgtccat tcctgctgag acctttttgg atgcaatgct 1135501 ttaaaaggat aaaataatgg aatttcatta ataatattac atttatccta aaaaattctt 1135561 gattttgcaa aatgattgta ataatataca actataaaat ttttcgataa ttcaatatta 1135621 tttattattt ctgaataaag ggattgcttt ctcttgaaaa cgtttgacaa caagaggggg 1135681 gaaaggggag ctagcatgag cacactttta gaagtgaata atttaaagac ttattttttc 1135741 aggaaaaagg agccgatccc tgcggttgac ggagtcgatt ttcacatcag caaaggcgaa 1135801 accgtcgcgc ttgtaggtga atcgggctcc ggaaaaagca ttacttcttt atcaattatg 1135861 ggcctcgtcc aaagctcagg cggaaaaatc atggacggct ctattaaact cgaagacaaa 1135921 gacctcacct cattcactga aaacgattat tgcaaaatcc gcggtaacga agtatccatg 1135981 atctttcagg aaccaatgac ctcccttaat ccggtgttaa caatcggaga acaaattacc 1136041 gaagtgctga tttaccataa aaacatgaag aaaaaagaag cccgtcaacg agctgttgaa 1136101 ctcttgcaga tggtcggttt ctcccgggcg gagcaaatta tgaaggagta cccgcatcgg 1136161 ctgtccggcg gtatgagaca gagggtgatg attgccatcg cactgagctg taatcctaaa 1136221 ctgctcattg ctgatgaacc aacgacagcg ctggacgtga caatacaagc ccaggtgctg 1136281 gagctcatga aagatctctg tcagaagttc aatacatcga ttcttctcat cacacacgac 1136341 ttaggtgtcg tgtctgaagc tgccgataga gtgattgtca tgtactgcgg acaagtcgta 1136401 gaaaacgcca ctgttgatga cttattttta gaaccgcttc atccgtatac agaaggcctg 1136461 cttacgtcaa ttcctgttat agatggagag attgataaat taaatgcgat taaaggcagt 1136521 gtgcctacac cggataatct gccgccgggg tgccgttttg ccccaaggtg cccgaaagct 1136581 atggataagt gctggacaaa tcagccttcg cttttgacac acaaaagcgg aagaacggtg 1136641 agatgctttt tatatgagga agagggtgcc gaacaatcat gacagcagct aatcaagaaa 1136701 caatcttaga gcttcgtgac gtaaaaaaat actttccgat ccggtcaggc ctttttcaaa 1136761 gaaaagtcgg tgatgtaaaa gcggtggatg gtgtttcatt ttcgttaaaa aaaggagaaa 1136821 cactcggaat cgttggagag tcgggctgcg gaaaatcgac tgccggcaga acgatgatca 1136881 gactgtacaa accgacagag ggccaaattc tttttaaagg gcaggatatt tccaatctgt 1136941 cagaggagaa gctgcggaag agtgtccgca aaaatattca aatggttttc caagatccat 1137001 ttgcttcgtt aaacccgaga aagaccctgc gttccatcat aaaggagccg tttaatacgc 1137061 acaacatgta taccatgcgt gaacgaaacg aaaaagttga agagctgctt gcaagagtag 1137121 ggcttcaccc gtcgtttgcc ggccgttatc cccatgagtt ttcaggcggc cagcgtcagc 1137181 ggatcggcat tgccagagca ctcactttga atccagagct gatcattgca gatgagccgg 1137241 tttccgcact tgatgtatcc attcaggccc aagtgattaa cttgatggag gaattacagg 1137301 aagaatttaa tcttacgtat ctatttatct ctcatgatct gagtgtcgtc cgccatatca 1137361 gcgacagagt cggagtaatg tatcttggca aaatgatgga actgaccggc aagcatgagc 1137421 tttatgacaa cccgcttcac ccatataccc aagcgctttt atcctccgtt ccggttacaa 1137481 gaaaaagagg ttctgtcaaa cgtgaacgca ttgtcctgaa gggagaactg cctagtccgg 1137541 ccaacccgcc aaaaggctgc gtattccaca caagatgtcc tgttgcaaaa ccgatatgca 1137601 aggaacaaat accagaattt aaagaagctg ctcccagcca ctttgtggct tgtcaccttt 1137661 atagctaatg ttgcccgcac agctttgaga gggggtatgc acactacata aacaacagcc 1137721 tagaagaacg aacatttcaa gagggggaat atctaatgaa aagacggaaa accgcactga 1137781 tgatgctaag tgtattgatg gttctggcca tctttttatc agcctgctcg ggatcaaaat 1137841 caagcaacag cagcgcgaaa aaatcagcag gcaaaccgca gcaaggcggg gatttggttg 1137901 ttggttcaat cggagaaccc acacttttta actctctgta ttctaccgat gacgcaagta 1137961 cggatattga aaatatgctg tacagctttt taacgaaaac ggatgaaaaa ctaaatgtga 1138021 aattgtcact cgctgaaagc attaaagaat tagacggcgg ccttgcatat gatgtgaaaa 1138081 ttaaaaaagg cgttaagttt catgacggaa aagaactgac tgcagacgac gtcgtattta 1138141 cgtacagtgt ccctttaagc aaagattaca agggagaacg cggttcaaca tatgaaatgc 1138201 tgaaatccgt agaaaaaaag gcgattacga agtcttgttt aagctgaaat ataaagacgg 1138261 taatttctac aacaatgcgt tagacagcac agctattctg ccgaaacata ttctcggtaa 1138321 tgttccgatt gctgatttag aagaaaatga gtttaacaga aagaaaccaa tcggttcagg 1138381 accatttaag tttaaggaat ggaagcaggg ccaatatatt aagctcgaag cgaatgatga 1138441 ttactttgaa ggaagaccgt atttagatac tgtgacgtat aaagtcattc ctgacgcaaa 1138501 tgctgccgtt gctcagctgc aggcaggcga tattaatttc tttaatgtgc ccgccactga 1138561 ctacaaaacg gctgaaaaat tcaacaacct aaaaatcgtt actgatttgg cattaagtta 1138621 tgtgtacatc gggtggaatg aaaaaaatga attattcaag gataaaaagg ttcgtcaagc 1138681 gctaacaacc gctcttgacc gcgagtcaat cgtcagccaa gtattagatg gagacggcga 1138741 ggtagcttac attccggaaa gccctttatc ttggaactat cctaaagata tagatgttcc 1138801 gaaatttgag tacaacgaga aaaaagcgaa acagatgctt gcagaagccg gctggaaaga 1138861 tacgaacggt gacggcattc tggataaaga cggaaagaaa ttctcgttta cccttaaaac 1138921 gaaccaagga aacaaagtcc gtgaagacat cgctgtcgtc gttcaggaac agctgaaaaa 1138981 aatcggcatt gaagtgaaaa cccagatcgt tgaatggagc gctctcgttg aacaaatgaa 1139041 tcctccgaat tgggattttg atgcaatggt catgggatgg agtttatcca cattcccgga 1139101 tcaatatgat attttccatt caagccagat taaaaagggt ttgaactacg tttggtataa 1139161 aaatgccgaa gcggataaac tcatgaaaga tgcaaaatca atcagtgaca gaaagcagta 1139221 ttcaaaagaa tatgagcaaa tctatcaaaa aattgcggaa gatcagccgt atacgttctt 1139281 gtattatcct aacaaccata tggcaatgcc ggaaaatctt gaaggataca aatatcatcc 1139341 gaaacgtgat ttgtataata ttgaaaaatg gtggcttgca aaataaattt cccttaaagg 1139401 ggagggagag cgttttctcc ctcttctgtt tttaataagg aaagtaaagg gggacaagta 1139461 tatggctgca tatattatca gaagaacctt aatgtctatc ccgattttat tgggaattac 1139521 gattttatca tttgttatca tgaaagccgc gcccggagat ccgatgacat taatgatgga 1139581 cccgaaaatc agccaggctg acagagagca gtttattgaa aaatacggtc tgaatgatcc 1139641 tcagtacgtt caatatttaa agtggctagg caacatggtg cagggtgatt tcggaacgtc 1139701 tattgtcaga aaaggaacgc ctgtttcaga attgattatg gcaagactac ccaatacgct 1139761 cctgctgatg ctggtttcaa cgattttggc tcttatgatt tctattccgt tcggtgtcct 1139821 gtcggcaaag cggccgtatt caaaaatcga ctatggcatt acatttacct cgtttatagg 1139881 cctggctatt ccaaactttt ggtttggatt aattttgatt atggtgttat cggtaaatct 1139941 cggctggttt ccaactgggg gtgtcgagac actgaatacc gaattcaata tatttgaccg 1140001 gattcatcat ttaattctgc ctgcattcgt tctagctaca gctgacatgg ccggactgac 1140061 gagatacacg agatccaata tgcttgatgt attaaatcaa gattatattc gcacagcgag 1140121 agcaaaagga tttaaagaga acagagtgct atttaaacat ggattgagga atgcattatt 1140181 acccgtcatt acaattttcg gtttgatgat tccttcattt atcggcggat ctgtcgttgt 1140241 cgaacaaatt ttcacttggc cgggattagg aaagctgttt gtcgattcag cattccagcg 1140301 cgattatccg gttatcatgg caatgactgt gatctcggcg gttcttgtcg ttgtcggaaa 1140361 cctcattgca gacatccttt acgcgattgt tgatccgcgg atcgaatatt aaaaggaggg 1140421 aaacagagat gtcagagctg caaacaactc cctcgccgga gatcaggctg aaagaaaata 1140481 tttcgaaaaa gccagaaaca atgacaaaga ttttctggga aaaattctcg aaaaacaaac 1140541 tggccatttt aggtgccgtt attcttttta tcattattat gtctgctgtt ttcgcccctt 1140601 taattgcacc ttatccccaa gagcagcaaa gcctgcttga taaatataag gcgccgggcc 1140661 ttgaacatct gatgggaacg gataaatttg gacgtgatat tttcagccgg atcctatatg 1140721 gagcgcgtgt ctctttattg gttggatttg cgtccgtagt cggttcgatt ttgatcggaa 1140781 cggttttagg agcattagcc ggatatttca gaggaatagt ggatgctgtc attatgcgtg 1140841 tagttgacat tgtgttatcc attcctgata ttttcttgtt gatcacgctg gtcaccatct 1140901 tcaagccggg tgtggacaaa ttgattttaa ttttctgtct cacaggatgg accacaacag 1140961 cacgattagt aaggggagaa ttcttgtcgc tccgttcaag ggaatatgtt cttgctgcta 1141021 aaacaattgg aacaaaaacg cacaaaatta ttttttctca tatcctgccc aatgcgttag 1141081 ggccgattat cgtgtcagct acgctgaaag ttgggtctgt tattctagct gaatcggcgc 1141141 taagctactt gggctttgga atccagccgc caatcgctag ctgggggaac atgcttcaag 1141201 acgcacagaa tttcacagta atgattcaag catggtggta cccgttattt cccgggctat 1141261 ttattttaat gaccgtttta tgcttcaact ttgtcggtga tggcctgcgg gatgcgcttg 1141321 acccgaaaaa tattaaataa aaatgaatat catatctgtt ataaaatatc accaaatcag 1141381 aaaaaagcag gtctccttta gtcagaaaat atacaaagag atctgctttt tatgattctt 1141441 acataaaccc agtgattcca gatttcctca atctctttgg aataatttct ctatcccttg 1141501 cctatactgt ggacaacagt ttttataaaa gtgaggggtt agagatgtta tttcttcatg 1141561 atgtgtgggt caattggttt gaaggggaag aaaatggcta caatgtatgc cactttcacg 1141621 aatggcgcaa ggaagatacg gttgagcttt tggatcaggt gccgctgtta agggtgccgt 1141681 cagtactgtt tcattacata gaaaacgatt tgtcagagct tccgaaaggt ttgcttgaag 1141741 acgtacatca gaaatcgtac attcgaaaaa atcatgagcg gacaaagctt gagtattgtt 1141801 ttgtcgtaac agacggaatc ggcattttag ctgttgacac gatcggctac acgatccctg 1141861 tcagaaaaag ccgtctaatc ccaagacagg agcagctcgt ttatgaaatg gtaaaagatg 1141921 tagagcctga aacatatgaa tttgagccaa agaagctgga atcctccaag gaatatcaca 1141981 tcttatcatt agcaccagaa catgtcagag gactgacaag aaaagaacgg caaattaagc 1142041 agctgatgtt tatggcgctt gaccaattaa aagggctgaa aaaccgagcg gaaattggct 1142101 actggtacac agagtggaat ccgcatatgt atgaacaaat caaaaggatg agctttgaag 1142161 agatttggga catgctgtat aacgaaacaa ttgaaggctg gtcggacaaa cacctagctt 1142221 tttgcgaaaa cctaataaaa ggacagcctt ttttcgaaaa gctttgggaa atggaaaacg 1142281 aatcaaaggt caactgaaaa aaaccgctct ttgcaaagag cggttttttg attagcgtct 1142341 ttttcttcca agacccatgg cattctccat ttttttcagc attttgtttg ctgtccgatt 1142401 cgctcgttcc gcgccttcat caagaatccg gtctaattct tcagattcta tcagctcgta 1142461 atagcggtcc tggatcggtt ttaatgcgtt cactacgact tctgccaaat cacctttaaa 1142521 ctcgccgtag ccttttcctt cgtactttgc ttcaagctct tcaattgtcg tattgccgag 1142581 gattgaataa attgtaagaa ggttggaaac gcccggtttg ttttccttat caaatttgac 1142641 aatgccttca gaatccgtta ctgcgctttt gattttcttt tcaagctgct tcggctcatc 1142701 cagcaatgta atataagctt tctgattcgg atcagatttg ctcattttct tcagcggatc 1142761 attcagagac atgatacgtg caccgacttt tggaattttc acttccggaa tcgtaaagat 1142821 gtcgttgtat tttttgttga agcgttctgc aagattccgc gtcagctcaa ggtgctgctt 1142881 ttgatcctcg ccgacaggta caagatccgt tccgtacagc agaatatcag cggccatcag 1142941 cggcggatat gttaacaggc cggagacgac agcttcattg cctttggatt tgtccttaaa 1143001 ttgagtcatc cgctcaagct cgccgatata ggcgacacac tgcatcatcc atccggcctg 1143061 cgcatgtgcg gggacctctg actgaataaa caatgttgct ttttctggat caagtccgac 1143121 agctaagtaa agcgccgcga gattgcggat attctttcta agctcaagcc ggtcttgagg 1143181 aacagttatc gcatgctgat cgacgatgca aaaatagctg ttataatcat gctgcagttc 1143241 gacaaactgc ttcattgcac cgatatagtt gccgagcgtc actgagccgc ttggctgaat 1143301 gcctgaaaaa atcgtttgtt tcatgaaaac atcaacctca tttcttaaaa cataataaaa 1143361 aaggctcatt cttcccctgt aaaaaaggga cgaatgaacc gtggtaccac cctgattatt 1143421 ccattaaaat ggaatcactc tgacgtttgt aacggagact gctccggctg agcctacttt 1143481 tttccagttc ggtcagctgc tccaaagtcc attccacatt gcccgttatc tgctcccagc 1143541 accgcagact ctcttcaaac aggtgaaacg tgtactactc tttttcatag caagcttttc 1143601 ttttgattgc ttcattataa atcaattata accaattgtc atcatgaaaa aacattcttt 1143661 tttccagtaa aattgtaata atataaataa cacgagtgct gtaaaatcct taaatgataa 1143721 ctgctatcag cgtaaaaaca ggcagatatt atatgtaaaa agcaatatgg gcagaaaaca 1143781 catgaaaaag tttttaatca atttatgctt taaatggtag aaggatatta tgttcatgga 1143841 agaaaaacta acgaagttta aatattttaa attgataaaa taatattgca ataaattatt 1143901 tgtttcatta taatgaactt gttcactcta ttgttacagc ttttttacaa aaataatcag 1143961 aaaagacgga acagaataaa agttgtggaa actcaggttc atttgtctga tatttctgag 1144021 gatttagccg taaggagctg aaaattatta ttagggggtt tgcgaatatg aaaaaacgtt 1144081 ggtcgattgt cacgttgatg ctcattttca ctctcgtgct gagcgcgtgc ggctttggcg 1144141 gcagcggatc aaacggtgaa gggaaaaagg acagtaaagg aaagacgaca cttaacatta 1144201 atattaaaac tgagccgttc tccttacatc cgggattggc aaatgattca gtatcaggcg 1144261 gtgttatccg tcagactttt gaaggattga cacgtatcaa tgcagatggt gagcctgaag 1144321 aaggcatggc ttctaaaatt gaaacgagca aggacggaaa gacatataca tttaccattc 1144381 gtgatggtgt gaaatggtct aatggagacc ctgtaactgc acaagatttt gaatatgctt 1144441 ggaaatgggc gcttgaccct aataatgaat cacaatacgc ttaccagctc tactacataa 1144501 aaggtgctga agcggcgaat accggaaaag gcagcctaga cgatgtggca gtaaaagctg 1144561 tgaatgacaa aacgctgaag gttgaattaa ataacccgac tccatatttc actgaattaa 1144621 ctgcgttcta tacgtatatg ccgatcaata agaaaattgc agagaaaaat aaaaagtgga 1144681 atacaaatgc cggagatgat tatgtatcaa acgggccgtt caaaatgacg gcatggaaac 1144741 acagcggctc tattactctc gaaaaaaatg accagtattg ggataaagac aaagtcaaac 1144801 tgaagaaaat cgatatggtt atgatcaaca ataacaatac ggaactaaaa aaattccaag 1144861 ctggcgaact tgattgggcc ggtatgccgc tcggacagct tccgacagaa tccctgccga 1144921 ccctgaaaaa agacggttct ttacatgttg agccgattgc aggagtgtat tggtacaaat 1144981 tcaacactga agctaagcca ttagacaacg tcaatatccg taaagcttta acatattcgc 1145041 ttgaccgtca gtcgattgtt aaaaacgtta cgcaaggaga gcaaatcccg gcaatggctg 1145101 cagtgccgcc tacaatgaag ggatttgagg ataacaaaga aggatacttc aaagacaatg 1145161 atgtcaaaac agcaaaagaa taccttgaaa aaggcctaaa agaaatgggc ttaagcaagg 1145221 catctgattt gccaaaaatc aaattgtctt acaacactga tgacgcacac gcgaaaatcg 1145281 ctcaagcagt acaagaaatg tggaagaaaa atttaggcgt tgatgttgag cttgataact 1145341 cagagtggaa tgtctatatt gataagctcc acagccaaga ttatcaaatc ggccgtatgg 1145401 gctggctcgg cgacttcaat gatcctatca acttccttga attgttccgc gacaaaaacg 1145461 gaggaaataa cgatacaggc tgggaaaatc cagaattcaa aaagcttctg aatcagtcac 1145521 aaactgaaac agataaaaca aaacgtgcag agctgctgaa aaaagcagaa ggtattttca 1145581 ttgatgaaat gccggttgcc ccaatctatt tctatactga tacttgggta caggatgaaa 1145641 acctaaaagg tgttatcatg ccaggtactg gtgaggttta tttcagaaac gcatatttta 1145701 aataaggcta cgtctgaaaa taaaagacct caaggtatat ggggagaaaa gccccatata 1145761 cctttcttac tgatggagta taaaaatgta aaaaccatgg aggtgttccc ccttgctaaa 1145821 atatatcgga agacgcttag tctatatgat tatcacacta tttgtgattg taactgtgac 1145881 attcttctta atgcaagcag caccgggcgg gccattttca ggtgagaaaa agcttccgcc 1145941 tgaaattgaa gcaaatttaa atgcgcatta tggcttggac aagccgctgt ttgtacaata 1146001 tgtcagttat ttgaaatcag ttgcaatgtg ggatttcgga ccgtcattta aatataaagg 1146061 tcagagtgtt aacgacctga tcagttcagg tttccccgtt tcatttactc ttggagcaga 1146121 agctattctc ctcgctttag cgttaggtgt attgtttggg gtcattgcag ccctttacca 1146181 taataagtgg caggattata ccgtcgcgat tttaacgata tttggtattt cggttccgag 1146241 ctttatcatg gcggctgttc tgcaatatgt gttctccatg aagcttgggc tgtttccggt 1146301 cgcggggtgg gattcctggg catacacctt tttgccttcc atcgcacttg cttccatgcc 1146361 gatggcgttt attgccagac tttcccgttc aagcatgatc gaagtgttaa acagtgatta 1146421 tatccgcaca gcgaaagcga aagggctttc ccgcccagcg gttacagtgc ggcacgccat 1146481 tcgaaacgca cttttgccgg ttgttacata tatgggcccg atggccgcac aggtcttaac 1146541 ggggagcttc attattgaaa ccatttttgg gattccgggg cttggtgcac acttcgtcaa 1146601 cagtattaca aaccgtgatt atacggtcat tatgggtgta acggtgttct tcagtgtcat 1146661 cttgctattg tgtgtattaa tcgtagatgt gttatacggc attattgatc caagaatcaa 1146721 gctttccaaa gcaaagaaag gagcctaggc catgcagaac attccaaaaa acatgtttga 1146781 accagccgca gcgaatgccg gcgatgcaga aaaaataagt aaaaagagcc tttccctctg 1146841 gaaagatgcg atgcttcgct tccgcagcaa taagcttgca atggtcgggc ttatcattat 1146901 cgtacttatt atccttatgg caatttttgc gccgatgttc tcaaggtatg attattcaac 1146961 tactaatctc ttaaatgcgg ataagccgcc ttcaaaagat cactggttcg gaacagatga 1147021 tcttggacgg gacattttcg tccgtacatg ggtaggggcg cgaatctcaa tctttatcgg 1147081 tgttgcagct gctgttctcg atttgctgat cggcgtcatt tgggggagca tttcaggctt 1147141 ccgcggagga agaacagatg aaatcatgat gcgtatcgct gatatccttt gggcagttcc 1147201 ttcattatta atggttatct tactgatggt tgttcttccg aaaggtctat ttacgattat 1147261 tattgccatg acgattacag gctggattaa tatggccaga atcgtgcgcg gacaagtgct 1147321 gcagctgaag aatcaggagt atgtgcttgc ttcacagaca ctgggtgcaa aaacatcccg 1147381 tcttctattt aaacatatcg tgccaaacgc aatgggttct attttggtca cgatgacact 1147441 gacagttcct actgcgattt ttacagaagc ctttttaagc tatttgggac ttggtgttcc 1147501 ggctccgctg gcaagctggg gaacgatggc ttctgacgga ttgcctgcat tgacctatta 1147561 tccgtggcgt ttattcttcc ctgccggatt tatctgcatt acaatgtttg gttttaacgt 1147621 tgtcggcgac ggattaagag acgcattgga tcctaagtta cgtaaataag ggagtgatac 1147681 gggtgacacg cctattagaa gtaaaagatt tagcaatttc atttaaaaca tatggcggag 1147741 aggtccaggc gatccgcgga gtgaatttcc atctggataa aggggagacg ctggccattg 1147801 ttggagaatc aggttccgga aaaagtgtaa cctctcaagc gattatgaag ctgattccaa 1147861 tgcctccggg ttatttcaaa cgcggtgaga tcctgtttga aggaaaggat ctggtgccgc 1147921 tgtccgaaaa agaaatgcaa aatgtccggg gaaaagagat cggcatgata ttccaagatc 1147981 cgatgacctc tttaaatcca acgatgaagg tcggtaaaca aattacggaa gtgcttttta 1148041 aacacgaaaa gatctcgaag gaagcggcta aaaaacgcgc ggttgaactg ctggaattag 1148101 tcggtatccc aatgccggaa aagcgggtga accaatttcc gcatgaattt tcaggcggga 1148161 tgagacagag ggttgtcatt gccatggcgc ttgcagcgaa tccgaaactt ctgatcgccg 1148221 atgagccgac aactgctctt gatgtaacga ttcaagcgca aattttggaa ttaatgaagg 1148281 atttgcaaaa gaaaattgac acgtccatca tctttatcac acacgatctt ggtgttgtgg 1148341 ctaacgttgc tgaccgggtc gctgtcatgt acgcgggaca gattgtagaa actggtacgg 1148401 tagacgaaat cttctacgac ccgagacatc cgtacacttg ggggcttctt gcatccatgc 1148461 cgacactgga aagttcagga gaggaagagc tgactgcaat tccgggcacg ccgcctgatt 1148521 tgacaaaccc gccaaaagga gatgcttttg ccctgcggag ctcttacgcg atgaaaatcg 1148581 attttgaaca ggagccgcca atgtttaagg tatccgatac tcattatgta aaatcgtggc 1148641 tgcttcatcc tgacgcgcca aaggtagagc cgcctgaagc ggtaaaagcg aaaatgcgta 1148701 aactggcaaa cacgtttgaa aaacctgtct tagtgagaga agttgaatga attgactgaa 1148761 aaactattag aaatcaaaca tttaaaacag cactttgtca cgccgagggg aacggttaag 1148821 gctgtagatg atttatcatt tgatatctat aaaggtgaaa cattagggct ggttggtgaa 1148881 tctggctgcg gtaaatcgac aacaggccga agcattatca ggctgtacga agcaaccgat 1148941 ggtgaggtgc tgttcaacgg cgaaaatgtg cacgggagaa aatcgcggaa aaagctgctg 1149001 gaattcaacc gcaaaatgca gatgattttc caagacccct atgcatccct gaatccgaga 1149061 atgacagttg ctgatattat tgctgaaggc cttgatattc ataagctggc aaaaacgaaa 1149121 aaagagcgga tgcagcgagt tcatgaacta ttggaaacag tgggattgaa caaggaacac 1149181 gcgaaccgct atcctcatga attttccggc ggccagcgcc aaagaatcgg gattgccaga 1149241 gcgcttgctg ttgatccgga attcattatc gcggatgagc cgatttccgc tttggatgta 1149301 tccattcaag cgcaggtcgt gaatttaatg aaagaactgc aaaaagaaaa agggctcaca 1149361 tacctgttta ttgcccacga tttatcgatg gtcaaataca tcagtgaccg cattggcgtc 1149421 atgtatttcg ggaaactggt tgagcttgcg ccggcagatg agctttatga aaatccgctt 1149481 cacccatata caaaatcatt gctttctgcg attccgcttc ctgatccgga ctatgagaga 1149541 aatcgcgttc gccagaaata tgatccgtct gtccatcaat taaaggatgg ggaaacgatg 1149601 gaattccgtg aagtcaaacc gggacatttt gtgatgtgca cggaagccga atttaaagct 1149661 ttttcatgat tcatcaatcc ttcaagagat ttctcttgaa ggattttttt gcgtcttcat 1149721 agaaagtgag aatgataaca tttacaatta gaggaaaaag cggaggcgaa atacgattca 1149781 atttctgcat aacaaaaatg tttttgcgct attgctgtct caatcttttc aatctttagc 1149841 aggagtcctc gtcacaatcg ttttaatggt ccggatctat caaatgactg actccgtttt 1149901 tttggcgggc cttattttat cgttcatgtc gtttgcgagt atagcagcaa gcttttgcgt 1149961 ctctccggtg cttcgcattc tcggttttaa aaaggtgctt gcgggagcga atctgctgag 1150021 agcggtcttt attatactga tggcatacag cgtcactcat cacggacagg cattcttttg 1150081 gattacgctg ctgtttgtgt tttgtttttc cttcgcgggc gctttttttc agccggcaag 1150141 atttgcgctg ctgccgatta ttgttccaaa gaagcaatat gtaaaagcga atggtgtgat 1150201 ctccctctcg aatcaattgt tcttaacagc aggctggggc cttggaggcc ttctgacgta 1150261 cgccgtccct tttgaactcg ttgtcggcgc tgccatttgc ctgtttgttc tatcgggagc 1150321 ttccatcagt gtgctgcatg taaatgaaga agaggctgca ggaactgctg aaacagcatc 1150381 tgtcagaagt atatggaagg atttaatgat catccctatt gtaagagaca ttactgtaat 1150441 ggacatgtta gaagctttgg cgggttccgt atggtcatct gctattctcc tcgcatttac 1150501 tgcggctgtt ttgcatgaaa cagaggtgtg gtgggggatg tttaacgctt cctattttat 1150561 aggcgcaatt gtcggcagtg tgattgctat tcgtttttct tctttttttg agcggaatat 1150621 gggctatgcc attatgttca gctcgcttgt aatgtcggcg ctgacccttt tgttttcatt 1150681 ttctccagtc ccatttttat gcgctctggc ttgtgctgca atggggcctt tttatcaggt 1150741 gcgtgatatt tgccaggaaa ccatgctgca ggaagttatt cccgagcaga aacgaatcgg 1150801 aatcatggct gcaaaaaatg cgattttgac tccttggtca ggcgtcacct actccattat 1150861 ggggctagtg gctgatgctg ctggtgcgaa aatagctttt atcgcggctg ctgcattata 1150921 tatcatgaca tttctgattg cactggcgca gccccgtctg gttcattaca ggcgagaaaa 1150981 tcgagttcaa tgagaaacac ttcaaaatga acggagcagc tggctccgtt ttgctgaaaa 1151041 aaaaatgaaa ccatggcgga agttcgcacg tctttataga tgtaaggctg tttaaacaag 1151101 aagaaatggg gtatatctaa aagtatgaag acaacgaact cataaggagc aaatcaatga 1151161 actggtatga aaagcttagc gagtactttc caattgaaga aatgaaatca aaagcgcata 1151221 tggaagctct tctgaaagag cgaagcgata tttatcataa agatgaaggc aaacatcata 1151281 ttttaatgtt tgcggaattc gattctttta tcttcgttga ttatctgtat gtgtctaagg 1151341 atgcaagagg gcaggggctt ggcggcaaat tgatcgcgaa gctgaaaaag aaaaataagc 1151401 ccatattgct cgaggtggaa cctgtggatg aagatgatac tgatacagaa aaacgcctga 1151461 ggttttatca aagagagcat ttcaagcatg ctcagtcaat tgggtaccgg cgccggtcat 1151521 tggctacgaa tgaagtaaac aagatggaga ttctgtactg gtcaccaaaa acagaatcag 1151581 aagaagaaat tcttgaagcc atgaaacaga catatgaaaa cattcatact tataaagatg 1151641 agaaatggta cggagaatcg tacgaaaaaa cggatgaggt cttggaaatc atcgatgaag 1151701 aaaaacaaaa aaatattttc gatcagttaa gctaattgag aataagaaca tatcatgaac 1151761 attaaaaatt tgctggattg acacattttt ttcttaggat actgttcaca cttacttttt 1151821 tatagtataa tacctgtaaa gattcctttt ttagagtaat ttcaatttaa gaataaaata 1151881 gatgttcatc ctactaatta gaggagtgaa gatgaatggt tacactatac acatcaccaa 1151941 gctgtacttc atgcagaaag gcgagagcgt ggctcgagga gcacgagatt ccatttgtag 1152001 aaagaaacat tttctctgaa cctttatcaa ttgatgaaat aaaacaaatt cttcgaatga 1152061 ctgaggacgg aacagatgaa atcatctcaa cccgttcaaa agtattccaa aaactgaatg 1152121 tgaacgttga atctatgccg ctgcaagatt tgtaccgctt gatcaacgag catccaggtt 1152181 tgcttcgccg tccgatcatc attgacgaaa aacgtttgca ggtcggatat aacgaagacg 1152241 aaatcagacg tttcctgcca agaaaagttc gctctttcca attaagagaa gcacagcgtt 1152301 tggcaaacta atagatcgta tcatcaaaag aaggctgagt catcagcctt cttttatttt 1152361 tcaacctgct ggtaataaat gctcgcaagg atgacaaacg caaccgtcaa aatggggagg 1152421 agcgtttcga ctgtgccgtg ctgcgccata aaaagcgaca gctttttgtc tctgacaatc 1152481 atttctccgc cagtataagc aagcagcccg cttcccgcgt aaatcagaag cggtattttc 1152541 tctagtgcaa tatggatgag tttgctgccc caaataataa ccggaaccga tacacacaat 1152601 cctataacaa cgagagaaaa ctcaccgtgt gaagctcccg caactgcgat gacgttgtcc 1152661 agcgacataa agagatctgc aagcacaatc gttcgtatcg ctctccacag ggaggtgctg 1152721 cttttaatgt gtttcgtgtc ttttttttca atcagcagct gatatcctaa atacagcagg 1152781 aaaattccgc cggcgcactg caagaacgga atgttcaaaa gatatactgc tgcacttgtt 1152841 aatccgattc tcatggcaac ggcaataaat gttccgagaa taatggcttg ctgtctttgc 1152901 ttgtccggca aatgtctgct ggccatggca ataacaaccg cgttatctcc gccgaggatc 1152961 aggtcaatcc caacaatgac gagcagagaa atcagatagt catgctccat gaagcggcac 1153021 ctcgctttca gtccttcgct tgtactacta ctatatgaga caggtcatat tttatgatat 1153081 cagccgcctg atctgccgtt ttttaggcaa aggtgcattt ttatttcttt tgtgactgtt 1153141 ttatcataaa atagaaatac aaaggaattc acactggcct tggttaaggt taagatgtgg 1153201 acggaatggg taaagtgtag taaagtacaa ttaatcggga gcttagatgt cccttcaaca 1153261 tcttatatag aagggaaggt tggcaaatgg aaattgaaag aattaacgag catacagtaa 1153321 aattttatat gtcttacgga gatattgaag atcgcggttt tgacagagaa gaaatttggt 1153381 ataaccgtga gcgcagtgaa gaacttttct gggaagtcat ggatgaagtt catgaagaag 1153441 aggaattcgc tgtggaaggc ccactttgga ttcaagttca ggcactggac aaaggattag 1153501 aaatcatcgt cacaaaagcc cagctttcca aagacggaca aaagctcgaa ctgccgattc 1153561 ctgaggataa aaagcaagaa ccagcatctg aggatcttga cgccttgctg gatgatttcc 1153621 agaaagaaga gcaagccgtc aatcaggaag agaaggagca aaagcttcaa tttgtcttgc 1153681 gatttggcga ttttgaggat gttatttctc tatctaaatt gaacgttaac ggaagcaaaa 1153741 cgactttata ttcgtttgag aaccgatatt atttatatgt agatttttgc aatatgactg 1153801 atgaagaggt tgaaaatcag ctaagcatcc tgctggagta cgcaactgaa tcctcaatca 1153861 gcatacaccg tcttgaagag tacggcaagc tgattatttc agagcatgct ctagaaacga 1153921 taaaaaaaca ctttgcatca tagcaaaccg atttccttcc ggaaatcggt tttttttatg 1153981 cacgaaaatg ccattttaga gatgtgaaaa atcaaaaaca tatagacaag cagaaaatac 1154041 agcgaacagg agttgatcat cttttccaga aagtatactt catctggaaa ggagagatga 1154101 caattgttta gtgctgtgac tgaagacggc caaatgtttc accttctagg cgctcagcaa 1154161 aaccagaaat taaagcggag acggttcttc tgtccggtat gcgggggaga gctagctgtg 1154221 aagctcggac ttcaaaaagc gccgcatttt gcccataaac agaacaagtc ctgcgccata 1154281 gacatcgagc cggaaagcgc ctaccactta gaaggaaaaa gacagctgta tgtatggctg 1154341 aaaacgcaac gggcttcacc aatattggag ccgtatataa ggacaatcaa ccaaagaccg 1154401 gacgtcatgg caagaatcaa ggagcatatg cttgctgttg aatatcaatg cgccactatc 1154461 gctccagatg tctttcaaaa gcggacagag ggcttcaaac aagaaggaat catcccgcag 1154521 tggattatgg gatacagccg cttaaaacgg actgcttcgt ccttttatca gctttcaact 1154581 tttcattggc agtttatcaa tgcaagtcca tacagagaac tgatatgtta ttgtcctgaa 1154641 aggcgttctt ttctccggct cagccacatc attccattct acacaaacca ttcttattcc 1154701 tcagtccaaa cgatccctat ccatcgggca ggtgcaggcg atcttttttt cactgaaccg 1154761 aaaccctcaa ttcaatattc aggctggacg aaagcgattc accgttttcg ccataaaccc 1154821 catcggttta actcaaagga aacaaatcgc cttaggctgc tgttttatga gaaacgacag 1154881 acgccttttt cttttctgcc gactgaagtg tttgttcctg ttagaaaagg ggcagttttt 1154941 aagagtccgg tttttgtgtg gcaggggttt ctttatttgt ttatgacgga tcttggaggt 1155001 aaacgtgcgc caattcgttt ttcagccgtt ttgcagcagt gcaaactgca cattcataat 1155061 aagaacattg cactcaggtc cgaatgcagc gaagagtgtc tttcagaagc ggttaaacag 1155121 tatattgatt ttttgtgcaa gaagggattt ttaagggaga ctcagaaaga agtatatgtg 1155181 ctgaatcagc ctgcaggagg catacactcc atgcaggatc tcatagaaag agaccgcagc 1155241 tgttttatag aatgagtttg tcttatttgg ctcaccctaa gacaaaggtg gtgggcaggc 1155301 tgtgaaaggc acaaaaggaa aggtttttcg tgtttttact gcttttttgg cattcgttct 1155361 cttcattact gcatatgatt tgacaaaagg cagtgaaaaa ccggaagata ttcacaacac 1155421 aagtttattg agaaacagct gttttttcaa ttggcttgaa tcaaagaaga cgagggggat 1155481 caccatggct gaggaaaaaa aagcaaacca actgcctgac agaagtgagg taaaggcaga 1155541 agacacatgg agacttgagg atatttttcc tagtgatgag gcctggaata aagaatttca 1155601 agctgtaaaa gaattaattc cgaatttatc taagtataaa ggaaagctgg cagattcagc 1155661 tgatcattta tacgaggctc ttacgtatca agataaagtg atggagcggc taggtaggct 1155721 gtacacatat gcgcatatgc gctctgacca ggatactggg aactcctttt accaggggct 1155781 gaatgacaag gcgggaaacc tgtatacaca ggccgcaagc gcgacagctt atttggttcc 1155841 ggagatttta tccatagaag aagacaaact gcagcagttc attcttgaaa aagaagaatt 1155901 gaagctgtac tctcatgcga ttgaggagat tacaaaggaa cgtccgcatg tgctgagcga 1155961 gaaggaagag gcgctgcttg ctgaagcctc cgaggtactg gggtcatctt caaatacatt 1156021 cagcgtgtta aataacgcag atataacgtt tccatccatt aaagacgaag atgggaatga 1156081 aaaacagatc actcacggca actttattaa tttcttggaa agtgaaaacc gtgaagtccg 1156141 caaaaatgcg tttgacgcag tgtataaaac gtacggacaa tataaaaaca caatggccac 1156201 gacgctaagc ggcactgtga aaaaggacaa cttctacgcg agagtgaaaa agtacaagtc 1156261 cgcgcgtgag gctgcgcttt ctaacaacag tattcctgag gaagtatacg ataaccttgt 1156321 taagacgatt aataagcatt tgccgctcct gcaccgctat attgcgctaa gaaagaaagt 1156381 gcttgagctt gatgaagtgc atatctatga cctgtataca ccgcttgtga aagatgctgg 1156441 gatgaaggtg acatacgagg aagccaaaga ttacatgctg aaaggcctcg cacctttagg 1156501 ggaagaatat gcctctatcc taaaagaagg actggaaaac cgctgggtgg acgtttacga 1156561 aaataaaggc aaacgcaatg gggcttattc atcaggagct tacggcacga atccgtatat 1156621 tttgatgaac tggcataata acgtcaataa tctctttacg ctcgtgcacg agtttggaca 1156681 ttccgtacac agctactata cgagaaagca ccagccttat ccatacggca attacagcat 1156741 ctttgtcgcg gaagttgcct ctacgacaaa tgaagcgctc cttggcgaat atttgctgaa 1156801 caatttagag gatgaaaaac agcgcttata tattctcaac catatgcttg agggcttcag 1156861 gggaacggtc ttcagacaaa cgatgttcgc tgaatttgaa catctgattc atacaaaggc 1156921 gcaagaaggc gagccgctta cacctgagct tctgacaaat gtctattacg acctgaataa 1156981 aaagtatttt ggagacggca tggtgattga taaggaaatc ggccttgaat ggtcgcgtat 1157041 tccgcacttc tattacaatt actatgtgta tcagtatgcg acaggttaca gcgctgccca 1157101 agcattaagc agccagattt tgaaggaagg aaagccggcg gttgaccgtt atattgactt 1157161 cctgaaagcg ggaagctcac aatacccgat tgatgtcctg aaaaaagcgg gtgttgatat 1157221 gacgtctcca gagccaatcg aagccgcgtg caaaatgttt gaagaaaaac ttgatgaaat 1157281 ggaagagctg ctgatgaaag tcaagcagtc ttaaaaaagt aagcctgtgc ggaaatgacg 1157341 cacaggcttt tttaaaaccc tttaaaggtt ttccggtgat tcaagcggta gagggtaaac 1157401 aaaatagaca gaaacagcag aggagaggta atataaagcg gcagcatatg catcatgcct 1157461 aagatattca agcagaaaaa aacagcaatg cacacaattg agatcaaagt agacatcatg 1157521 gcggtcctcc tcgtcctttt tccttataag gatatgagtg aatgcacttc gttatgtttt 1157581 gtgacaaaaa tatgaacatt aagcatagag gttgtcaaaa gtcgacatct tttgttatca 1157641 taaggatgtg aaattgatca caaacaaaca ttaccccttt gtttgaccgt gaaaaatttc 1157701 tcccatcccc tttgttgtcg ttaagacata tgaaaccgcg cttatcccgg cgcggtttct 1157761 ttagtgctaa aaatggaacg tacgtttggt tatggcataa aaaaacagcc tcaagcatat 1157821 gcacgcctgc ggctattttt cacatgattg atattcatca gaataagtgc tgagagactt 1157881 ccaaaacatt ccgtgtttgg cttccacttt ggcaaccttt ttagcaaacg ccagtttttt 1157941 catttctttt tctacctctt caaggctcag gtcatataca agagcaattt ccttcgaggc 1158001 aacgaagcgg aaatattcaa taaaacattc taaaggcggt gtttccgacg gcttcggctc 1158061 gtcgccaagc atctcaaata aaatttcttc atatacatca tatgagtagc tgccaggaac 1158121 tttaagccct tcatcctcat gctgcgtatt aaaaaacgtc agtgtcggat taacagaaac 1158181 atccatctcg gcagcaattt tcatgtcaca ttgaagcgcc ttgaccgcgc tttgagaatg 1158241 cagatctttt ttgaattctt caagatcgag acttgtattt tcagcaatct ccaaaagcac 1158301 gttttcatcc gtaatatttt tctttgaaac aaataggctc tcctgcatat ttctgagaaa 1158361 ttgcatgccg gcttttcgtc cttgcagttc ggctgcttta aaagcgagag cagccatata 1158421 aggcgatgaa agcggctgat cctgttcgaa ccagacattg ccgtcacatg acatgccaga 1158481 gcggctcgcg atcttttccc atgcttctgc gagaagatgc ttttttcgct ttttatttaa 1158541 agcggtaagg cttgcggaag cgataatgcg taaggtgaaa aaacgtccgt atctgatttt 1158601 cagctttttg atgacgggct ctaaggacca gcattcagga cataaagggt ctacaaacat 1158661 ataaatttca agcggttttt ttggatgacc gtggcaatgg gcgaagtata gctcatgctg 1158721 atagtttgtc aagatgatcg atcctccgct tccgtttgat tcaccatatg ccttgctgtc 1158781 aactccagcc ggccaaacaa aaactcacga atttcgccct ccagccctac atggtccatt 1158841 gcgtccttca tacagctgag ccacgcatca gctctctcgt ttgtaattgg aaagggaaga 1158901 tgccttgctc tgagcatagg atggccgtgt tcctcagtat aaagaggagg cccgcctaaa 1158961 tactgagtta agaattgctt ctgtttcctg gcggtttctg tcaaatcgct tggaaaaatc 1159021 ggcttcagca aaggatgaga cgcgacacgc tcataaaaag tatcaacaag ttgcgataga 1159081 agttcctctc caatcgcttc ataaggtgcg ttaaacgatt gtcccatgtt gactactcct 1159141 ttaaatatgg ctaataggaa tcataaatcc tattgcaaaa agtaattttc tgtatttcat 1159201 tgtttcatct agatttattt tagcaacaag gcatcatttc tacaaacaaa ctgcctttta 1159261 tgcgtttgat gactcatttc ggctgacagc cggggtttgt atttcatatc atatcacata 1159321 aaaatcagga atgcgtaaga tttcacttcg caaaaaaacc agagggaaag agcacctctg 1159381 gttacgcgta ataaactgaa gttatttttt ttacatagtt ttgcgtttct tggaaaggag 1159441 gaatgcctcc gtatcggtca acattccccg gtccggcgtt gtaagccgct aatgccatag 1159501 acacattgcc gtcgtattta tccagcattt gttttaaata tttcgttccg ccctccacat 1159561 tttgctgcgg atcaagcgga ttggaaacgc caagtgagct tgctgttgac ggcatcagct 1159621 gcatgaggcc catcgcacct gctccgctga ccgcttttgc attaaagcct gattcctgtt 1159681 tgatgacggc gcggatcagt ttttcatcaa cgccatattt atcagcggct tttttaatcg 1159741 cactgtcaat agagaagtct cccgaacgga tctgatttgc ttcatgtttg tttgaagctg 1159801 aatctgcaac agctgtttca gtgctttctg ccgcttttgt gactgaacct gaattgctgc 1159861 tcgtatatga gttaagccca tacgctgaaa gcagtgacgg cgctgttgta ttcgcgctgt 1159921 tcagcatgct gagcgggctt ggcgatgaag aaggtgctga ttgctgagat gtcagaccgt 1159981 ttgtatattg gctgagcaaa gaactgaaac ttgaaagcgg gctttccgta ttctgagtgt 1160041 ccgagctgct gcgtgcatta gatatggact gtaatgcctg aagctgaagt aatgctgccc 1160101 aattcgttac attcacgatg tcattccacc ttatatagac tttcgttttt cttcataaaa 1160161 acgcagaatt ttatttttgg tttcgcgctg aggaatgctg aattgctgaa gcagcttttc 1160221 gaaggcttgt ctgccctcat gccaatccgc cgcctcaaat tcaatttcat agtcctcttt 1160281 atttaaatat cggctgtggt ctaaaactat taagcctttt tctgtttctt tttccgcacg 1160341 gtttgttgct aaagatccaa agtattgtat ggcatccgta tcgatctgaa gcttgtgcag 1160401 ctggtccttc acagggccct cgggaactga aaatccagcg agatctgata cctctgaaag 1160461 ctgctggtgc gtttccagaa gccccacatc agccggctcc tttaatgtaa ggacatactt 1160521 tccgtttttt ctgcggatac gaagcgcagc atgtttttgt ttcagcgcga agctgtctgt 1160581 atcaaaataa tgattctttt gatctgtaaa atctttttct gtcagctgga gtgccgatgc 1160641 tatgtttttg aattcttgtt tggtcagcat gtttttaaat tcgatttcaa tctcttggct 1160701 catgatgctc ttcctttccg ccctgtaaat cttattttta ctattatctc tttagatgtt 1160761 aggtttatca atatcgagct cgatatgata aaatgaatct gtactttgtt taaaaaagga 1160821 gagcattatg caaaacagaa tcgaaatttt gaatgcaaca ttatcggatg atcagcttcg 1160881 ccttgcctgt cagacagaag gaaacgaagc ggaacgcaag ccgtcaggtc aaatgcttgt 1160941 tgattctgac cactttgctt ttgtatacat acttgaatta gctgattctt ttgaatatgt 1161001 cattataaag gaacatgtat ggccggaact gaagcaggcc catgcacaaa aaataccggt 1161061 tgttttagag gcaggagacc aaacaattga actggcaggc ctgcatgagg agctggaata 1161121 tcttttagaa aatataaaag ataatgcaaa ctatggagaa gaaatggaag aaaaagtgaa 1161181 acgcgtgttt ttatagaaac tggttcggaa ttgggggatg tatgatggat gacaaacaat 1161241 gggagcgttt tttagtgccg taccgccagg ctgtcgaaga gttgaaagtg aagctcaagg 1161301 ggatccgcac actatatgaa tacgaggacg accattcacc gatcgaattt gtgaccggac 1161361 gcgtcaagcc tgtggcgagc atacttgaaa aagcgagacg gaaaagcata ccgctgcatg 1161421 aaattgaaac catgcaggac attgctggcc ttagaatcat gtgccaattt gtcgatgaca 1161481 tccaaatcgt aaaagagatg ctttttgcca gaaaagattt caccgttgtg gatcagaggg 1161541 attatattgc ggaacataaa gagagcggat accgatcata ccatcttgtt gtgctgtacc 1161601 ctttgcagac ggtatccgga gaaaagcatg ttctcgtaga aatacagatc cgtacactgg 1161661 cgatgaattt ttgggcgacc attgaacatt cattgaatta taaatacagc ggaaacattc 1161721 ctgaaaaagt aaaactaagg cttcagcgcg cttctgaagc ggcttcccgg cttgatgaag 1161781 agatgtcgga gatcaggggt gaagtacagg aagctcaagc tgccttttca agaaagaaaa 1161841 aaggaagcga gcaacaatag gtaaagggga agaagagcat gaaatttgcc gtatcatcaa 1161901 aaggagatca agtttctgat acgctgaaaa gcaaaataca ggcgtattta ttggattttg 1161961 atatggaact ggatgaaaat gaaccggaaa tcgttatttc agtcggaggc gacggaacgc 1162021 ttttgtatgc ttttcacaga tacagcgacc gtttggacaa aacagcattt gtcggcgttc 1162081 acacaggtca tctgggtttt tatgccgact gggttcctca tgaaattgaa aaacttgttc 1162141 ttgccatcgc gaaaacgccg tatcatacag tcgaatatcc gcttctcgaa gtcattgtga 1162201 cctatcacga aaacgagcgg gaagaaagat acttagcttt gaatgaatgt acgattaaaa 1162261 gcatcgaagg aagccttgtt gctgatgtgg aaatcaaagg gcagctcttt gaaaccttcc 1162321 ggggcgacgg cctctgcctg tcaactccat caggcagcac agcctacaat aaggcgctgg 1162381 gcggagcgat tatccatccg tctatcaggg cgatccagct tgcggaaatg gcttcaatta 1162441 ataaccgcgt gttccgtacg gtcgggtcac ctctgcttct cccatcccat catgattgca 1162501 tgattaagcc gagaaacgaa gttgactttc aagtgacgat tgaccattta acccttctcc 1162561 ataaggatgt aaagtcgatc cgctgccaag ttgcatccga aaaagtgcgg tttgcgagat 1162621 tccgtccgtt tccattttgg aaaagagtcc aggattcgtt tattggaaaa ggtgaataga 1162681 aagaggacat atcgtggagc atttttttat cagaaagaac attacttccg ctgaggacgg 1162741 gatgactgta aaagaatatg ccggtgaact gggaatttcg aaacgtctgc tgaccgatat 1162801 taagtttggc gggggagacc tgcagattaa cggtgagcat gtgacggtca aatacgtttt 1162861 gaaagaggga gatcttctta tcgtgaagtt tcctgaggag caggtgagcg agacgctgtt 1162921 ggcagagcct gttccgctcg atatccttta tgaggatgaa catgtgcttg tgataaacaa 1162981 gcagccgtat gtgtcatcaa tcccttcgag agagcacccc tccggcagca ttgccaatgg 1163041 aattattgat cattatcaaa caaccggagt gagggcgaca gttcatcttg tcacccggtt 1163101 agaccgggat acatcaggta tcatgcttgt tgccaagcat cgatttgccc actccatttt 1163161 atcgtctgcg caaaaaaacg gccttgtgaa acgccggtat gcggcagtgg ttcacgggcg 1163221 gatggcacag atggagggaa cagtcgatgc tccgattggc agacatcctg acagtattat 1163281 tgaacggacg gtaacgccag acggccagaa ggctgttact catttttacg tcacatgtgc 1163341 aaatgatgac atgacctcgg tggcattgca gcttgagact ggacgaaccc atcaaattcg 1163401 tgttcatatg agctatctcg ggcacccgtt gtgcggcgat acactgtacg gcggaacgag 1163461 acaggaaatt ggccggcagg ctctgcacag cgagcatctt tcgtttatcc atccgctgac 1163521 acaggagaac atgaggtttc atgctccact gcctcaggac atgagcaaac tgataaaagg 1163581 agagaatcat tgattctctc cttttttata tggggcgaaa tcttgattcg tcgtaaggca 1163641 gggagcttgg aacagagacg gtttctattt ctggaaagcg aaagcctgtc agttgatttc 1163701 cgaacacgca gcctgtatca atgttgatgg tgcgattgac cttccgaggc tctttcacag 1163761 gtgtatgacc gtataccacc caagcctttc cgttataggc tgccgcccaa tcacgcctga 1163821 tgggtctgcc gtccggatat gtttcacccg tcacgtcacc gtaaagcaca aagtccttca 1163881 ctctgcgggt atatttgccg atatcgtcag ctcttatgcc agcatgggcg acaactaatt 1163941 ctccattatg taagatgtcg taaagcggcg ctgtttcgta cagcttcata aactgttcgc 1164001 tgactgattt tttctcatct ttggaaagtt cctcaagctc tgccgctgtt gtttcgagac 1164061 catgcatcac ttttaccgga tttcctttta agtaacgata taatttattg caatggtttc 1164121 ccgggacata acgcacagcg cctttttcgt aagcgccggc tacaaatcgg atgacctcta 1164181 tcgatttggg ccctctgtca gttaaatctc cggcaaaaac aagcaccctg ccttcttcat 1164241 ggacaggtac tccatttttg attgtatagc caagcttttg gattaatgca gtcatttcgt 1164301 catagcagcc atgaatatcg ctgatgatat cgtaagccat gcggtctcct ccttaccgat 1164361 tgttttattt attatgaagc aaagtgttgt gagtcatcac aagcttttat gtgcaaatta 1164421 tagaagaaga atcattttct aaacaggatt aagaccttat cactttattt ttcatcatca 1164481 cccttgttaa aatcgcgtta tgttttttaa aaatgaggtt ttgttctctg agtgagaact 1164541 agcataaccc tgacttaaaa aggaggttct gattatggcg catacatctg tcgcatcttt 1164601 agttgttgta cttatcgttg catttttgac acccatcctt ttgcatcggt ttaaactcag 1164661 catcccggtt gttgttgctg aaatcattat ggggctgata attgggaaaa gcggccttaa 1164721 tttagttgtg gagggtgaca cctggctcca gacactctct atgctcggat ttatcttttt 1164781 aatgttttta agcgggcttg aaattgattt ttcgtcgttt gagaaaggaa agaaaaagca 1164841 gttcctgccg aatggcaagg aagcgccgaa tacgtttgct gcggcatctg ttattttcgt 1164901 cggtattttt attttatcat tgctcttgtc ctatgggttc gtcttggccg gatttatcca 1164961 aaatgcattt ttgatgaccc tgattatttc aacgatttca ttaggcgttg tcgttccaac 1165021 attaaaagaa gaacggatca tgaattcgaa tatcgggcag attattttgc ttgttgctgt 1165081 tattgctgat ttggccacga tgattcttct tgctgttttt tcttctttat acggagagga 1165141 cagcggaaac atgtggctcc tgatgattct gtttgcggcc ggagtggtgc tttacttttt 1165201 cggccgggtc ttcaaacatc gctcttttgt tcaatccatg tcaaaaggga cgatccagat 1165261 cgggacgcgt gccattttta cgttaatcat tgtactcgtt gccctgtctg aatcacttgg 1165321 ggcggaaaat attctcggcg ctttcttagc gggggttctt gtttccctgc tttcgccaaa 1165381 caaagaactt gttcagcagc tggactcatt cggttatggg ttcttaatac cgattttctt 1165441 cgtgatggtc ggtgtgaagc ttgatatttg gactcttttc caggataaaa caattttaat 1165501 catgattccg ctcctgctgc ttgcgctgtt agtcagcaaa atcattcctg tcatgtactt 1165561 aaagaagtgg tatgataacc gaaccatttt cgcgtctggt ttcctgctga catcaacgct 1165621 ttcgctcgtg attgctgctg caacaatcgg ccagcagctt cacgtgatca gtacaaatat 1165681 gtcaggagcg ctaattttag tagccgtcat tgcaagtatt tttacgccga tctgttttaa 1165741 aaaattatac aaacgggaag agcagccgga ggagaaaaag acgattacgt tcattggcgc 1165801 caatcaaatg actttgcctg tcacactcga attgccagag gaagagtatg acgtgcgtgt 1165861 tgtacacgtc taccaagaga atgcggagga aaagctgtca gaatcagtgt ttgctgttga 1165921 aacaatttct gactatgaac acgagacgct tgaatcactc ggcatttttg aaacggatat 1165981 cctcgttgtg gcgacaggaa atgaagatat gaatgcagac attgcattac ttgcaaaaga 1166041 taaaggcaca gaaagagtca ttgcaagcgt aggatcaccg gagcatgaag cagctctgaa 1166101 ggagcaggga atcagcatct tttctattct gctgtcgaca aaaacgctgc ttcgcgcact 1166161 gattgaagcg cctggcgtca tgaagctgct cacgaaccaa gagtcttcgc tgtatcaaat 1166221 taatatggag aacagtaaat atgatggtgt cattttacgg gaattccctt taacaggtga 1166281 cgtcatcttt gtcaggatct tcagaggtgt ggacagcatc gttcctcatg gggatacgag 1166341 gctgaaactt ggagaccgtt taattgtcac cggatctcgg gggtacgtaa cggatcttaa 1166401 gaaaacattg gaaggataaa tcttgaccaa ataaggattc gtgttaatat agaggtgcag 1166461 aacaattcaa tatgtattcg tttaaccact aggggtgtcc ttcataaggg ctgagataaa 1166521 agtgtgactt ttagaccctc ataacttgaa caggttcaga cctgcgtagg gaagtggagc 1166581 ggtatttgtg ttattttact atgccaattc caaaccactt ttccttgcgg gaaagtggtt 1166641 tttttatttt cagaggggga atgatttgtg aagttttcag aagaatgccg cagtgcagcc 1166701 gcagaatggt gggaggggag ctttgtccat ccgttcgttc aaggaatcgg tgacggaacg 1166761 cttccgattg accgttttaa atactacgta cttcaggatt cctattattt aacgcatttt 1166821 gcaaaggtgc agtcatttgg tgccgcttat gcgaaggatc tttatacaac ggggcggatg 1166881 gcaagccatg cccaaggtac atatgaggcg gaaatggcgc ttcatcgcga gtttgccgag 1166941 ctgttggaaa tcagcgagga agagcgtaag gcgtttaagc cgtctcctac ggcgtactct 1167001 tatacatccc atatgtaccg ttcggttttg agcgggaatt tcgcagaaat cttagcggcc 1167061 ctgctgccat gctattggct ctattacgag gttggtgaga aattgctgca ttgtgatccg 1167121 gggcatccaa tttatcagaa gtggattggc acatatggcg gtgattggtt tagacaacag 1167181 gtcgaggagc aaatcaaccg ctttgatgag ctggcggaaa acagcacgga ggaagtgcgt 1167241 gccaagatga aagagaattt tgtcatctcc agctactatg aatatcaatt ttggggaatg 1167301 gcctatcgaa aagaaggctg gtctgacagc gccataaaag aggtggagga atgtggagct 1167361 tcacgccata acggatgaca gcaagccggt agaagagcta gcgagaatca tcattacgat 1167421 tcagaatgaa gttgatttta ttcacattcg ggaacgctca aaatcggcgg cggatatttt 1167481 gaaactgctc gatcttattt ttgaaggcgg tatagataaa cgaaaattgg tgatgaacgg 1167541 gcgcgtggat attgcacttt tctctactat tcaccgcgtg cagctgccaa gcggcagctt 1167601 ttcaccgaag cagatcagag ccagatttcc acaccttcat atcgggaggt cggtgcattc 1167661 actggaggaa gcggttcaag cagaaaagga agacgcggac tacgtgctgt tcggccatgt 1167721 gtttgaaacg gattgcaaaa agggtcttga aggcagagga gtatctttgc tgtcagatat 1167781 caaacagcgg atttccatcc cggttatagc catcgggggg atgacgccgg acaggttaag 1167841 agacgtaaaa caagcagggg cagacggcat tgctgttatg tcaggaattt tctcttccgc 1167901 tgaacctttg gaagcagcca gacgatattc ccgcaagcta aaggagatgc gctatgaaaa 1167961 ggcattatga agcagtggtg attggaggcg gaattatcgg ttccgcaatt gcttattatt 1168021 tggcaaagga aaacaaaaac accgcattgt ttgaaagcgg aacaatgggc ggcagaacga 1168081 caagtgccgc tgccggaatg ctgggcgccc atgccgaatg cgaggaacgt gacgcgtttt 1168141 ttgatttcgc tatgcacagt cagcgtctgt acaaaggtct tggagaagag ctttatgcat 1168201 tatccggtgt ggatatcagg cagcataacg gcggtatgtt taagcttgca ttttctgaag 1168261 aagatgtgct gcagctgaga cagatggacg atttggactc tgtcagctgg tattcaaaag 1168321 aagaggtgtt agaaaaagag ccgtatgcgt ctggtgacat ctttggtgca tcttttattc 1168381 aggatgatgt gcatgtggag ccttattttg tttgcaaggc atatgtgaaa gcagcaaaaa 1168441 tgcttggggc ggagattttt gagcatacgc ccgtcctgca tgtcgaacgt gacggtgaag 1168501 ccctgttcat caagacccct agcggagacg tatgggctaa tcatgttgtc gttgccagcg 1168561 gggtgtggag cggaatgttt tttaaacagc ttggactgaa caatgctttt ctccctgtaa 1168621 aaggggagtg cctgtccgtt tggaatgatg atatcccgct gacaaaaacg ctttaccatg 1168681 atcactgcta tatcgtaccg agaaaaagcg gaagactggt tgtcggcgcg acaatgaagc 1168741 cgggggactg gagtgaaaca ccggatcttg gcggattgga atctgttatg aaaaaagcaa 1168801 aaacgatgct gccggctata cagaatatga aggtggatcg tttttgggcg ggactccgtc 1168861 cgggaacaaa ggatggaaaa ccgtacatcg gcagacatcc tgaggacagc cgtattttat 1168921 ttgcggctgg ccatttcaga aacgggatcc tgcttgctcc cgcaacgggc gctttgatca 1168981 gtgatctcat catgaataaa gaggtcaacc aagactggct gcacgcattc cgaattgatc 1169041 gcaaggaggc ggttcagata tgatgctaca gctgaacggt aaagacgtga agtggaaaaa 1169101 agacacaggt acaattcaag acctgctggc gtcgtatcag cttgaaaata aaatcgttat 1169161 cgtggaaaga aataaagaaa taatcgggaa agaacgctat cacgaggttg agctttgtga 1169221 tcgtgatgtc attgaaattg tccattttgt aggaggcgga tgagcatgtt aacaattggc 1169281 ggaaaatcat ttcaatcaag attgctgctg ggcacgggga aatacccatc gtttgacatt 1169341 caaaaggaag cagtagctgt ttctgagtct gatattttaa catttgctgt aaggagaatg 1169401 aacatttttg aagcatctca gccgaatttt ctggaacagc ttgatttatc caaatatacg 1169461 cttttgccga atacagcggg cgccagtact gctgaagaag cggttcggat tgcaaggctg 1169521 gcgaaagctt caggcctttg tgacatgatt aaagttgaag tcatcggatg cagccgttcc 1169581 ttgctgcctg accctgttga gacattaaaa gcgtctgaac agcttcttga agaaggcttt 1169641 attgtgctcc cgtacacgtc ggatgacgtt gtgctggcga gaaagctgga agagctcggc 1169701 gttcatgcca tcatgccggg tgcatctccg attggatcag gacaaggaat cttaaatcct 1169761 ttgaatctgt cgtttattat tgaacaggcg aaagtaccgg tcatcgtgga tgcgggaatc 1169821 ggctcgccta aagatgcggc atacgcaatg gagcttggag cggatggcgt actgctcaat 1169881 acggctgtat ctggcgctga cgatcccgtg aaaatggctc gtgccatgaa gctcgcagtg 1169941 gaagcagggc gcctttctta tgaggcgggc cgaatcccgc ttaagcaata cggaacggca 1170001 agcagtccgg gagaaggtct tcctgtatga caggcaggta ttcaaggcag gagctgtttg 1170061 ctccgatcgg cccatccggc cagaaaaaat tgaaagaagc gcgcgccgtg attatcggcg 1170121 ccggcgcgct cggaacagcc agtgcagaaa tgctggtgag agcgggagtc ggctctgtga 1170181 aaattgccga cagagattat gttgaatgga gcaacctcca gcgccagcag ctttatacag 1170241 aagatgatgt caaaaaagaa atgccgaaag cagccgctgc ggagcgccgt ctccgttcga 1170301 ttaacagcga tgttgatgtg accggccttg tcatggatgt gacagcagaa aatatcttcg 1170361 agctgattag ggatgcatcg attattgtgg atgcggctga taattttgaa acccgcctga 1170421 tcgtaaatga tgctgcggta aaggaaggga ttccttttct ttacggtgcc tgtgtaggga 1170481 gctacggtct tacctttacc gtggtgccgg gttctactcc ttgcctgcat tgcttgctcg 1170541 atgcacttcc gattggcgga gcaacatgtg acacagctgg catcatcagt ccggctgttt 1170601 tgcaggtagc agtctttcag gtaacagatg cactgaaact gctgacggga gaggagtgcg 1170661 agccggtgct gcgctccttt gatttgtgga aaaacgagcg gtcagaagtg agagcggcca 1170721 gtctcaaaca tgacgcatgc ccaagctgcg gcacaaagga ttttccgttt ttgtcttatg 1170781 aaaatcaaac aaaagcggct gtattgtgcg gcaggaacac ggtgcagatc agatcatcta 1170841 ttacgaaaga agcggatctt gaagcgcttg ccggtcagct gaggcaggcc gggcttgaag 1170901 tagctgcgaa cccgtattta atttcctgcc gctcggatga tatgaaaatg gtgctgttcc 1170961 gggacggcag agctttgatc catggaacaa atgatattgc ccgggcaaaa tccatttatc 1171021 ataaatggat tgggtaataa aaggagtgta gtgtaatgag tatatataaa gcattgacaa 1171081 tcgccggatc agattcaggc ggcggcgcag ggatacaggc tgatattaaa acctttcaag 1171141 agcttgatgt attcggaatg tctgcgatta cggcggtaac cgctcaaaat acgcttggcg 1171201 ttcacggggt gcatccgctg actgtagaga cgttgagaca gcaaattgac gctgttgctg 1171261 aggatttgag accggatgca gttaagacgg gaatgctctg gaatgccgac atgattgaag 1171321 aagtggcaag aaaaattgac gagtacggat tcaatcgtgt aattgttgat ccggttatga 1171381 tcgcaaaggg cggggcatcc ttgctgcgtg atgagtcagt tgccacctta aaggagttgc 1171441 tcattccaag aagctacgcg attacgccga atgtcccgga agcagaaacg ctgacaggaa 1171501 tgacaatcag ctcgctggat gaccggaaaa aagcagcgga gcagctcgtc aagatgggtg 1171561 cgcagcatgt cattatcaaa ggcgggcacc agcctgagga caatcacatt actgaccttc 1171621 tttttgatgg cagcatgttt atgcaaatca cccatcctta tatcaatacg aagcatacgc 1171681 atggcacagg ctgcaccttt gctgcggctt taacggccca aacggctaaa ggagacagca 1171741 tccatcaggc atttgaggtt gcggccaact ttgtccgtga agcggtggaa aatacgctcg 1171801 gcatcggatc gggacacggg ccgacaaacc atttcgcttt taaacgaaac agcttaaata 1171861 caagccgatg agatcaccag ctgatggtga tctcttttgc gtttgctacg gtatgcgctt 1171921 ttcatctgga caaggttatg atatgatagg aattaagatc aggtactaat actatgtctt 1171981 tattaaatat aggaggcttt atacatatga atttttcact tgaaggccgt aacattgttg 1172041 tgatgggggt agccaacaaa cgcagcatcg cctggggcat tgcgcgttct ttacatgaag 1172101 cgggtgcacg tttgattttc acatacgctg gtgaacgcct ggagaaatcc gttcacgagc 1172161 ttgccggaac attagaccgc aacgattcca tcatcctccc ttgcgatgtt acaaacgacg 1172221 cagaaatcga aacttgcttc gcaagcatta aggagcaggt cggtgtaatc cacggtatcg 1172281 cgcattgtat cgcgtttgcc aacaaagaag agcttgtcgg cgagtactta aacacaaatc 1172341 gtgacggctt ccttttggct cataacatca gctcatattc tctgactgct gttgtcaaag 1172401 cggcacgtcc gatgatgact gaaggcggaa gcattgtcac tttgacgtac cttggcggag 1172461 agcttgtgat gccaaactac aacgtcatgg gtgtagcaaa agcttctctt gatgcaagtg 1172521 tgaaatattt agctgctgac ttaggaaaag aaaatatccg cgtcaacagc atttctgccg 1172581 gcccgatcag aacattatct gctaaaggca tcagcgattt caactctatc ttaaaagaca 1172641 tcgaagagcg tgcaccgctt cgccgcacga caacacctga agaagtgggc gatacagctg 1172701 cgttcttgtt cagcgatatg tcccgcggga ttacaggtga aaatcttcac gttgattctg 1172761 gtttccatat cactgcccgc taagcaggat ctatatcaag caatcccgaa tagggattgc 1172821 ttttttattt cttctgattt tcagctttct gtcatataga tagaatatga cacaatcgga 1172881 gggatgaaga tgtctaataa gaaaagaaac gcggataaaa aaccgctcat gtatattgtt 1172941 cagccggatt atgcagaaac tacaaggtca tccatgcagg agattgtcat caaaagaaag 1173001 gccgacaaac ccgctccgcc aaaagctgag gaaaagccgg cttaccatga gaagcagcag 1173061 gaggaagccg tggcacagga tgtcctgcaa gaagaccaaa agcctgcagc cgaaccagtg 1173121 agtcagcaaa cacaagaggc gagagagcca gagaacataa aaagccaaga ggaacagaag 1173181 gcagagccgc aggccgtaga agaaaccgtt gaacacgagc ccccgaaagc agaaaaaaag 1173241 gaagagcctg cacttgaggc ccggaagcct gagaaagaac cggaagctgt ccatagtgct 1173301 gataaagcgg aggaaaaagc accgccggca cgaaaagtga aaaaaccgat gagcaagatg 1173361 acgatccacg aaaaaattga ttttttaaca aagctgcctc ataacatgcc gagagcgctt 1173421 tgtttgattg aagccaatgg aagaacgtac aggggcgtga ttgtcggaag aagaaatgat 1173481 tccgtcctgc ttcgaacaac cggaaacgga gccccaaccg aactggcaat cgatgatatt 1173541 acctctttgc acccgctcgg tttttaacga aaaagaaaaa agctgcccgg ctgatgttgc 1173601 cggacagctt tttttacata gagaaaagcc tgcaggcctg caagcttttc cagcttatga 1173661 ttaatgatga tgtgtacgat tgattaatcg aggatttaag cagttgattg cgcagaagca 1173721 gtctaagtca acttcaatac agtagttcgt tttttcgagt cggaacactt cacacaccgt 1173781 atctttatcg gtgaagtcca aaatgtgttt gtgttcgtca aatgcgatta ataatgacag 1173841 tgttgcacag cttccatgca ctctttcgac cctgaaaaat actgtattaa agcaagggcc 1173901 gttatcgagt tcgccgacat ttccgaaggc gactaatggc gttgattttg atgtaaatat 1173961 tgcaaaaggc actgtgtcgc ctaacgaatg gcttacagat aaaagcttag agtggcagcc 1174021 ggtcgggcag tcttcttcaa cagcgttttg cagatcttca atattttcta cagcttcacg 1174081 cacgcagctt gatgttttct ggctcatatt atccctcctg ccttataaat ttgagactgg 1174141 cgaaatgatg gagagtcagc tgcctcacgc tggaagcagc tgaatgattt gcacctgtaa 1174201 tagagtttgg aaggggattc ctctttacaa gtgtttatcc attgtgatga tgctttttat 1174261 ctttgtgagg cgatgttctg tcaactagct ctggtgacag gcactgaatc gcgcagaagc 1174321 atccgagatc cacttcaatg cagaaatctg ttttttctag cccgaagaaa tccgggtcgc 1174381 aagggtggca aacacttaag gtatcgcctt tgacatcgac cgggcgtaaa atagacagtg 1174441 ttgcacagca atcgcataat ttttcgacgc ggaagaaaat ggattcaaag cattgcatat 1174501 catccacaaa tccccctacg tttccgaatg tggagaacaa tccgcctttt ttatcaaaaa 1174561 cgagaaacgg aattgtgtct tttccagcaa tcgtagggtt taaaaggttg gtatagcagc 1174621 cagtcggaca ctgttcttca actgcctcct gctctgctaa aatcttttcc actgcatcgc 1174681 atacacagtt ctcatgccgg ccatgggttt ttccgcagct cattgatttc agctccttct 1174741 ttatagggta tttgacttta gtccttaaca acatatgtac ccgtgcccca cttggtgtgg 1174801 gtgaacgtct atatattcat catatgcttg gaaaataaga aaaagcagag cgtttttagc 1174861 tctgctttta ggtcctagag gacaagagtg ataactagga tggctacgag tgtatttgtt 1174921 gctgtagaaa taagggttgc gatatcggca tctactgttg tgacgtttac gccgcgggaa 1174981 cattcgatga gaagtttttg gcggtttact tgtttgttag ctgtaagctg taacaaatct 1175041 tgtgcgacta attcggcaat tacgccgtct gcaattgatg tcagagttgc cgttacgaca 1175101 gcggcattaa gtgctgttac aactgatgtt acggcttgaa cgtctgtaga tgtaacattg 1175161 atgtcacaag aatctctaat aataatcgtt tcatctgaaa cttgtttgtt gagatttgct 1175221 tgagctagat cttggtcgat gaaggcgttg tcgttgccaa aaaaaccatt gccattacag 1175281 caaacgtcgc aatgacattt tctttcgtgt ttttctttat ctttctcttt gtcatctaac 1175341 ggatggtcac agtcaggatc aagtgcaacc caagaatatg gtctgctttc catatctatt 1175401 cctccttttc ttttactgtt attaaatgag cgagcctctt attttgactg agtcatatat 1175461 cctgatgaag aaccctattt tttatgattg gctaattgtt atcgtttttc cgtctttgtc 1175521 tgatctgttc aatgagctgc tctctgcggc ttaacggttt tgtgttcttt tgctcttgtg 1175581 cggctgcttc ttcttttttc ttcttttggt tttctattag cgcttgtgat ttagcttgta 1175641 agtcttttac aagatttaag agcatttctt tttcttcgtc tgatactttt ttcattttgt 1175701 cttttgtgac cccatgttta gaaaatatat tttggaccag cattttcgtc attggatcaa 1175761 cttctggaag ctttgcaagc tcttctttga atttatcgtt atctgacatt tgttttcacc 1175821 tcgtctttta agtttgtgaa aagaaagggt taaaggacgt caagttcact aagaatgctg 1175881 tttaacacct gaagcaagat ttgtacaaag gttattatct cgtcggcaga caaagtaatt 1175941 ttgatgttgc ggctgttgat aattttaatg atggttcttt ttttgatttg ggagctatcg 1176001 agaataagaa tttcacttgc cactgcgtca gccaaatcct cgtcggcgat gacgagctga 1176061 gtcgccacga taatcatggt tgtcacaaag gcttgtatag aaagggcagc tgttatatgt 1176121 gacgtgtcaa ttgtgatatt ttcgcaatca atcacttcga tctgctgttc gaattcgctt 1176181 gataattgct caaatattgc agggtgcagg gattcgactt tttcttcaaa tgacataacc 1176241 ttcactcctt tcttatccat actctatata atgcaaatgg ggtgcagagc ggaataataa 1176301 aaataaccaa ttttctgccg gacaagatac aattcatgaa gaatagggtt ttggcatata 1176361 tgtgaaggga tcatgattgg caaaggagtg aacgagtggt tataaatggg ctgacaattg 1176421 ttcttctatc gcttgcggtc tttcggctcg cccgcctgct ggtgtttgac acgattatgg 1176481 cgccgcttcg cagtctgttt catgaagaga aggaagaaaa ggatgcggac gggaacattg 1176541 aaacctatat cgtgattaag ggaaccggtg tcagggcgtt tattggtgaa ttgctgagct 1176601 gctattggtg cacaggcgtg tggtgtgccg gctttttgat tttatgccag gcggtgatcc 1176661 cgcaagcggc gcagtggctg attttacttt tggcgatcgc cggccttgcc ggcattatag 1176721 aaacgctcgt atcaaaatgg ctgcaagaat aaggcgttac caccagcaac tttctgtcag 1176781 aatacgcata aagtagcata tatgacataa ggaaaggaag gggacaaaaa tgaatcagca 1176841 tcataaacct tcccaaaaat ctccatatac agattcatcg tatcaatcaa aaaagataaa 1176901 aaagaaaggc tgcgggtgcg gaaataaaaa gaaaaagcct caatagcctg gcaaagaaac 1176961 cggagaactc cggttttttg tttttttaac gaggcggtct cgctcagcat atatcataag 1177021 cggggggata aaagtgaatg agtttgaaaa atggatagaa ggaagatatg aaccacatga 1177081 acaaaagcaa aaagagcatg aagacacgat gggcagtatc agaaaagact tggatgcatt 1177141 tgataaagcc ggtctggaat ttgaagatga gattgaagag ctggctgaaa aaacggaggc 1177201 cttacttaaa aaacatcaag ctcaatatga tcaatcgtaa atccgcaaac gccctatgcg 1177261 aatatccaag ccgatcccag cagctcacat agtgtataga gagtaaagga ggtgcttatc 1177321 tatgggcttt ggatacggat tcggcggcgg ctacggcggc ggctgttatg gcggttatgc 1177381 tggcggttac ggcggcggct atggttcaac atttgttttg ttggtcgtat tattcattct 1177441 cctcatcatc gtaggtgcat ctttctttta agatgtattg aggaagtacg ggttataacc 1177501 cgtacttcct tgccttgtgt ttatttttaa aaatgttgga aaagcacatt gtattatgtg 1177561 cattcataca ataccgtatt actccgccaa aaggaggcgc attatggata atcaattttt 1177621 taagaacatc gaaaagaaaa caggtgtgaa gatgcaggat gtaatgaatc ttgccggatc 1177681 actccaaaac gctaatttta aagatgaaaa tacagtgcgc agtgtgatta accgcgtagc 1177741 gcagatggca aacagacgcg tgccaaaaga attagaagat aaaattgtgg aatctattac 1177801 aagcggaaaa gaaaagcttg attttggcac gatttctaaa atgatggata ataaataagt 1177861 ggatggcctg gctgactcac tgcagcgggc ctttttttac agtaaaaacc cggcagtaat 1177921 ctgccgggct gttaatgatg caagggctgt cttgctttct gtagcagggg atacaaaaat 1177981 cttgagcggt tggctgtttt gccgcgcctg ttagcagggc aagacaaata taaatgctgt 1178041 ttcgcccggg tcatggctac atataaaagg cgtctttcct cctcaagagc ggcctcgtct 1178101 ccttttcttg ccgtttctaa tgagaaatcg tgcggaatcg agccatctac agtgcctaac 1178161 acgtagactg ttttgaattc aaggcctttt gaccggtgaa tggtcatcag ctgaacgcca 1178221 tgttcatccg ttctgttttt ctcagcggcc ctcatatggt ctacgtgggc aagaaagtca 1178281 ggaatcgttt tgaacttctt ggcgacaacc ttgatgtcgc gcaggtcatc agagcctttt 1178341 tccagcttgt tgccctcatt gccccgcttt tttaaatact cggagaagcc catttttcct 1178401 tctgcaaagg tgatggcttc tacgggtttc attgtgcgga ggcttgcaaa aaacggtacg 1178461 attttcttga ttttgtccag ctggaatggc ttcagatcag gcaatttggc cagcgctttg 1178521 atcatggtac agtcctctgt aatcgagagc gccttcagcg tattcaaagc ggactgtttt 1178581 aaaaacaagg cgggaagcaa gtgtttaatc gcctcggtgt catcctcatt ttggctggcg 1178641 tacaagtagg cgagaatctg gcggacgatc cgtctgctgt aaaacgattg gacgccgcgg 1178701 tcagctgtat acggaattga cgattgatga agcctttcat atatagcacg gcctccgctg 1178761 tttgtgcggt aaagaaccgc aaagtcttct ggactggctc cattttgaat tttttctttg 1178821 atatcggaaa cgaccattgt ggcttcttcc tcttcatcat aaggataaaa cagcacaggg 1178881 acctgaatgt catcgcgggc cgcttcaagc gttttggcat atctgttttt gttctttttc 1178941 acaacgatat cagcactaga gacgatcggg tgcgtagacc tgtagttcgc agttaaatag 1179001 atcgtcttcg ctcccggata atccttttga aaatcaagaa tgaaagacgg attgcttccg 1179061 cgaaacgcgt agatggactg gtcatcgtct ccgacacagc acaggttttg ctccgggctg 1179121 gcgagcattt gcatgatttt gtattgaacc ggattaatgt cctgaaactc atcaattaag 1179181 atatacgtaa accgagattg atattgttcc agaaggtcag gccgctcgat aaacaattca 1179241 tagcaggctg aagccatgtc atcaaaatca aattggctgt gttctttttt ctggcgttca 1179301 taatgttcat ataaacgata aacttgtttt tcccactcat cttttagagg gatgcgttca 1179361 tttgggacat aagtgttttt ccaaaaaccg atctgctgca gggcttggtc aactggggat 1179421 tctttctcat cgatgccttc ttcatagagt gcttttttga tatattgttc ccgctgccac 1179481 tccattttca gcagatgctc accgttccat ttagcagaat tagagtgata caagatctta 1179541 taaaacagac tgtggaatgt tcctgtcaca attcttctga cttttgccgg ctgtaatccg 1179601 tactggttcg ccatacgctc tttcatttca gcgacagctt ttgttgtaaa ggtgacaagc 1179661 agcatatttt caggcggtat gcctaagtgt tcgatcatgt gggcggcacg ggctgtcagt 1179721 acccgtgttt ttccgctccc cgcacctgca agcacgagga gcgggccctc tgtttccgtg 1179781 acagctttca gctgatccgt gtttaaaccg acagacggaa aaaggctcgt atcgggttct 1179841 attgtttttg gcacaaatgg tgttcctggt ttaatgcttc taggacggtg ccattctgta 1179901 acagctgggg acgggtcagc ggcgatcgct tttcccttgg gtaaacgaat gacaccagat 1179961 tcctgatcat cttctttttt cccctcttta gagggcttcg gttcgcacgc ctcctcacat 1180021 gccggaaaat cgcctggctg gcgatggata aactctggcg gatcggcgat gttaagccgt 1180081 aacaaaacgg gctttccgca atgagaacaa aataaatgtc cttttattcc ctcttcaaag 1180141 aggaattgat aatgttctct cgaatatgta tgtaaatgta tgattctatc attcagtcgg 1180201 gcgcatttca aaaaggggtc ctcccaatca aaaggtgttc attacagaca atgactatca 1180261 tatcaaaaga aatgtgtttc aaaaagtaag tttaagggaa aagagacagc agaggggtgg 1180321 gtattgtatg atatatgcag gtcaaattca gaaccagcaa tacgctcaat atgctaatag 1180381 aacgattgga cataagcagg attatgccgg aaccgaaaaa atcagctatg tcccgtttca 1180441 gcgggtatac aaagaactgg aaaagcagca ggagaatcaa acggcagctg aaagaaaagt 1180501 aaacgagatg aaacgtaagc gctctcttta taagagattg cgagaaaaag gaatggggac 1180561 atatattaat cgatatgtat aaaaaaccgt tcataccaga gaacggtttt tttatatgca 1180621 gtaaaaatcc ggatctcaaa agatccggat gcgttcagtc cttcatcatt tgtaagtgcg 1180681 gaatgccggc atcgaggaat tctttttcag aaagcacgcg atacccgtgt ttcttgtaaa 1180741 acggcacagc ctgtgtttgc gcgtttaaaa tgaaaccgga agcgcctccg tctgccgcgg 1180801 ctttttcgag cgctttcata atgatgccgc cgacaccggc tgagcggtgg cttttcagta 1180861 cgcaaatccg ctctaacttg ccgtagccgt ccttcatgcg ccatcttccg gcaccgacag 1180921 gcttttcacc gtcatacacg acgatatgct ctgactcatt ttcaagttcg tcaatttctt 1180981 cttcagcagg cacgttttgt tctttgacaa agacttcttc tcttacatag aatgcatctt 1181041 tcagttgttc ttcatttttt gcgataactg ctttcaaaca ttattctcct ctgcctagca 1181101 agaaggtttc atatactgtc cacgatccgt tttccaactg gtagagcaag tggaaacggt 1181161 caacgatttc ttcatgcgac acttcctgca tttttaattg tcccagcaca tctgaatgct 1181221 catcgtcgga aagattttgg ccgaccgtca catgcggaac gaaattatat tcctgttctc 1181281 ctgccaacac accggtgtat agcttttcat tgagtgtttt taactcttcc gtcggttctg 1181341 ctttgatgta aatgacatta ttgacaggcg caaatgagct gtattttgtc attttgagaa 1181401 cgagtgggtg ggactctttt gcgatgtttc ttaaatgtga tacgagctga tccgctttct 1181461 cctccgcgca ttcaaaggat gctctcagcg tcaaatgagg cgggattaga gagtagcttg 1181521 ggtcatagcg ctttctgtaa gagtttgcaa ggtcttggag cttttttgat ggaaataaaa 1181581 cgattccgta tttcatatta tgtccctcct ggaaataaag tatgatagag tgttaaagca 1181641 tttttttcag cgccggggtg atgagcggct gccagtatgt ccatttgtgg tctccgtcaa 1181701 atggctcgaa atcataatcg gaaagctttt tctccagcag ctgtttcagc tcccggttcg 1181761 gttctgtaaa gtccagaatg ttcccgtctg tcgtgtggac gtcagtttct tttgttccga 1181821 tttggtgata aatagagagg tgtttgatat cgtctgactg ttttacggct tctagtacgt 1181881 gtttgtcaac atagggagac tgcatgatga tgttgccaaa catattcgga taatcaagcg 1181941 ctgtcataag tgacacggtt gctccgagcg aatcaccgat cagcgttcgg ccgtaaccga 1182001 tctgataggt tggatactca tcatctgcaa aaggaacgag ctcatgggcg atgaaccgtt 1182061 tataagccga aaattttgaa ccctccggat gataagtgtt tctgcgctct tttacatcct 1182121 tatagggaac accgataata atgctccggt ctatttcgcg tttcgacagc aattcctcaa 1182181 cctgtctgcc gattctcccc agcctgaaat aatcgtggcc gtcctgcgcg ataatgacat 1182241 ggtatttata aagcggggag tagttggacg gcagataaac aagcaaggtc atttcctcgt 1182301 taagctcttt tgaaaagaat ttcttttctt gcactgtgcc gtttttcggt gccataaaaa 1182361 cattcctcca ggacatcact atactttctt gcattttcaa ttattgtacc atgaattatt 1182421 agaaatttct ctctttaaac ggttcggcac acgaagaaaa aagtgttgaa ataaactgtg 1182481 aattgcgcta atataaaaca atcagaaaat tgaaatcgat atttcttatc gtgagaggtg 1182541 gagggactgg cccttagaaa cctcagcaac cggcttgttt tgcatttgca aagcgccaag 1182601 gtgctaaatc cagcaagcgt tttttatgct tggaagataa gaagaagcgt taaacccctt 1182661 cttcttatga agaaggggtt tttattttga aaagggaagg tgtcagctat atgtcacagc 1182721 acgttgaaac gaaattagct caaattggga accgtagcga tgaagtcacg ggaacagtga 1182781 gtgctcctat ctatttatca acagcatacc gccacagagg gatcggagaa tctaccggat 1182841 ttgattatgt ccgcacaaaa aatccgacac gccagcttgt tgaggacgcg atcgctaact 1182901 tagaaaacgg cgcgagaggg cttgccttta gttcgggaat ggctgctatc caaacgatta 1182961 tggcgctgtt taaaagcgga gatgaactga tcgtttcatc ggacctatat ggcggcacgt 1183021 accgtttatt tgaaaatgaa tggaaaaaat acggattgac ttttcattat gatgatttca 1183081 gcgatgagga ctgtttacgc tctaagatta cgccgaatac aaaagcggtg tttgtggaaa 1183141 cgccgacaaa ccccctcatg caggaggcgg acattgaaca tattgcccgg attacaaagg 1183201 agcacggtct tctgctgatc gtagataata cattttatac accggtcttg cagcggccgc 1183261 ttgagctggg agctgacatt gtcattcaca gcgcaaccaa gtatttaggc gggcataacg 1183321 atctgcttgc tggacttgtc gtggtgaagg atgagcggct cggagaggaa atgtttcagc 1183381 atcaaaatgc aatcggcgcc gtcctgccgc catttgattc gtggcttctg atgagaggaa 1183441 tgaagacgct gagcctcaga atgcgccagc atcaggcaaa cgcgcaggag cttgcggcgt 1183501 ttttagaaga gcaggaagaa atttcggatg tgctgtatcc cggaaaaggc ggcatgctgt 1183561 ccttccgtct gcaaaaagaa gaatgggtca atccgttttt aaaagcactg aagaccattt 1183621 gttttgcaga aagcctcggc ggggtggaaa gctttattac ataccctgcg acccagacgc 1183681 acatggatat tcctgaagag atccgcatcg caaacggggt gtgcaatcgg ttgctgcgct 1183741 tttctgtcgg tattgaacat gcggaagatt taaaagagga tctaaaacag gcattatgtc 1183801 aggtcaaaga gggagctgtt tcatttgagt aaacacaatt ggacgctgga aacccagctc 1183861 gtgcacaatc catttaaaac agacggcgga accggggcag tcagtgtacc gattcagcac 1183921 gcctcgactt ttcaccaatc ttcatttgaa gagttcgggg catatgatta cagccgctct 1183981 ggcacgccga caagaacagc tctcgaagaa acaattgccg cactggaagg cggaacaaga 1184041 ggatttgctt tcagttcagg catggctgcc atctcaacag catttttact gctgtcacag 1184101 ggtgatcacg ttcttgtgac agaagatgta tacggcggaa ccttccgtat ggtgacagag 1184161 gtgctgaccc ggtttggcat tgagcatacg tttgtcgaca tgacggatcg taatgaagtg 1184221 gcgcggagca tcaagccgaa cacaaaggtc atttatatgg agacgccatc aaatccgaca 1184281 cttgggatta cggatattaa agcagttgtt cagcttgcaa aagaaaacgg ctgcctgacc 1184341 tttctggaca atacattcat gacgccggca ctgcagcgtc cgcttgatct cggcgtggat 1184401 attgtacttc acagcgcgac aaaattctta agcggacaca gcgatgtgct ctcaggtttg 1184461 gctgctgtca aagatgaaga gcttgggaag cagctgtata agctacaaaa cgcgttcggc 1184521 gccgtccttg gcgtgcaaga ttgctggctt gtcctgcgcg gattaaaaac attgcaggtc 1184581 cgtttagaga aagcgagtca aacagctcag cggcttgcgg aatttttcca gaagcacccg 1184641 gcggtcaagc gcgtgtatta tccgggactg gctgatcatc ccggcgctga aacccataaa 1184701 agccagtcaa cgggagcggg cgccgtgcta tcttttgagc ttgaaagcaa agaggccgtt 1184761 aagaagttag tcgagaatgt gtcactccca gtcttcgctg tcagccttgg cgccgtggaa 1184821 tcgattttgt cctatccggc aacgatgtct catgcggcaa tgcctaagga agagcgtgaa 1184881 aaacgcggta tcactgatgg cctgctccgt ctgagtgtcg gcgtcgaaca tgcagacgat 1184941 ttagaacacg atttcgaaca agcgctgaaa gaaattgctc cagtttcggt tcgttaaaaa 1185001 agaagccggg gatagtccgg cttcttttat tattgttcgt catcaggatt cagaatcgcg 1185061 aggacttgat gatcctccca aacgccatta atttttacat tttttcgggc gatgccttct 1185121 ttatgaaatc ccgctttttc taaaacacgc atggacccga gattacgggg catcacaccg 1185181 gcttcaatcc gatgcagttt caattcgtgg aacgcataat caacaaccaa tctgactgcc 1185241 tctgtcataa tgccctttcc attatgggct ttgtctaaaa aatacccgat gaacgcagtt 1185301 tgcagcgcgc cacggatgat ttgaaagagc gaaaccgtcc cgattaatct atcgtctgac 1185361 gctgtaaaga tgccaaaatg atattcttca tctttctcaa gtctttcctg atactcggtt 1185421 attcgttttc tttgcccctc aaccgtatag taatcgtctg cgcgtatcat agaaaactgt 1185481 tcgaaaaaat ctcgattttc gctttgcagc cccagatttt cttcggcatc cgttacttct 1185541 aaaggtctaa cataaatggt ttttcctttt aacatatagt gatctctccg ttctcatgtc 1185601 agcattcctc ttacattatt ctcagggaaa tgcaaatatc ctttttataa gaaggaagaa 1185661 aaccaatttc ccataaaagt gccaacatag ttgccgatta agtagccgag cgtaccgaca 1185721 agcatgatcg gggcgacaag ctcccgccat cccttggcaa ttgccatcgc agccgcagtc 1185781 gtcggtcccc cgacagtagc gttgacggcg agcagaattt cttcaagccg cacacggaac 1185841 aattttccgg cagctaagga aaccgctaaa ttgctaatcg caatgataaa cacgaataat 1185901 agaataagag gcgcattcgt gacgattaag cggagatctg caggaatgcc gatcaccaca 1185961 aaaaacaaat aaatcaaaaa ggttccaagc tcctgagatc cattgagcct ttcaaaaaaa 1186021 cgcgggaaaa gaaaaatgat aagaacagtt aaagacgtaa gaaccaggta ctgatcgcca 1186081 agcgtaccgg tcagcagggg atgagaaaaa atgcttttaa aataaccgga aaccttcata 1186141 ctaaccgcaa caagcgcgaa agcggcaccg gcattaaaag cgatatcctt taaggaaata 1186201 tccttccgtt tccaatagct ttcagcactg tttccgctgt ttccatcggc ttttaccttc 1186261 tcttcaaacg gcatggcata atgccgctga aaccatttga gtgcaggaat gctgattaaa 1186321 ataaaaaaca aaagcgccat cataaaatta tcagccacaa cggtagccga cacatattca 1186381 ccaggcgtct caaattttgc cgccatcgcc gcaaagttga ccccgccgcc gatataagag 1186441 gcgctgatca tcccaccgat tttatctaag taaggaatat gctgtttgag tagaaaaaaa 1186501 gccaggatac tgccaagcac tgttccaacg gagctaatca gaaaaataaa cagcaaacgc 1186561 ctgctttcct taaaaatttg cctaacattg atctgaaaca ataaaagtgg tatcgccagc 1186621 ggtaccacat aagaccacac agtgtcatac acgggcgact caacaggaag cactcctaca 1186681 tttgtaaaca ccatagcacc tgcaagggcg ataatagcgc ccgacacagc agacgcccac 1186741 ttaaagcgct gctccagccc gatgctcact gccgcccaca ccgcaataaa cccccataat 1186801 acccatacat catcagaaga aatcaaagaa tgcaaaaccc catcacctct attgttagaa 1186861 aattaagaca tattataata gccggggaac ggaacagcaa gtccaaaaaa agtttttcta 1186921 aaaaagcagt tgacgaatag aaggtaaggt tatataatag aacttgtcag aaagataaca 1186981 acatacccag caacacatac atatcatgat tccgtagctc agctgggaga gcgctacctt 1187041 gacagggtag aggtcgctgg ttcgagccca gtcggaatca tagcttaaac ccttgcgcag 1187101 caagggtttt ttactttgcg ttaataaagc cggttcgtca aattcgtgag ttgttggcga 1187161 actgttggcg aaattcattg accgcagtcc aaaaactacc tccaaactta cttgattagt 1187221 tcaatagtaa caaacggaag atcggatttc tgttaaatct tcattgagaa tagccagtcc 1187281 aagaccgtca cttcagccat gcatctttta aatgaaattt tgtactgaaa acatcaattg 1187341 tatttttaaa ttctgctcta gaatcagccc ctttataata atcttgataa attgcttggg 1187401 gtgatactga ttcgtgattt gtgctatggt ttgcaaggct tgtagcaaaa gcaggagcaa 1187461 cagtaacgag taaagcaagg gataatgcaa aaccagttaa agctttttca atttcatttt 1187521 aagcacttct ttttttaaaa tacaacttta ttattaaatg gaatacaaaa acatccaagg 1187581 tgtttttttg ttagtaagtt gagttagggg gattggatgg cacttagaat attgtttctg 1187641 ctgatgggat gttgattctg gatatatttc caacacgatt acaggccgga catgaaagcg 1187701 aaccttgctt tgatcggggc aatcatttca tttacggctg cggtttactt taaagatatt 1187761 gatgtattga gagaagaggg aaaacaaatg aacggaattt ctgagcgttg gaacacgttt 1187821 aaattacaaa aatcccctga accactctag atcaggggat tgctttccca acagcttatt 1187881 aagtagcgga aggcatgatc aacgatttag tatcaattta ttaattgcga atactagaaa 1187941 cataccgttt tccgccttcc ttagaagtaa catattctcg aggaacatta agtctattgg 1188001 tagaatgata acttacataa agtttcatat ttgctcggct cgttacgata gccgtatgat 1188061 ccatccaacc atcagcatag cgaagaccta ttttattatg gtaatcatag tgatatacat 1188121 ctccaagctt tacatttgaa tatgtatcag aaacagtctt catttttatt ccgccagctt 1188181 ttaaaatgta tgatctaaag gctcctgcat taacccaagc atctgtatag ggtttccatt 1188241 ctttaaagta cggcattctt ccagctctta atgcttggga aacaaagtta gtacaatctt 1188301 tgtctttata atatttatag tttttatttg gttttaaggc atatttttct gcatatttca 1188361 ttgcagcgta accactatat cctttaacag atgttgcagt cacagttagt tgattagagt 1188421 tagcagcatt gaagttcata cttactggtt tatcttcact tttcacttct tctttatcat 1188481 catttttcac ttcttgctta tattttttta aaaattcatc taatttaaca tccgaagaat 1188541 attcttcatc attttcatat tgtagagttg aagaagaatt atttaattgt gttacattta 1188601 gttgcttaga agaattactc aatggtatta catttagttg attagaagaa tttttaactt 1188661 gagagaaact tagattagaa gtatttgttg attgagaact ttgtttatta gaagttgttt 1188721 tgggaatttc aagtttaata ttatcgccca gagatgttgt tactttttca acaccaaaaa 1188781 caaagtttcg agtaatataa gcttcaacaa ttagcttatt gtttttttca gaagtcttaa 1188841 catcgtctat atcgtatgta aactcgtgga atttttgttt gtccacttta cttaacgcag 1188901 aatacagtaa gactccttcg tcggaatcag tcaatttaga ctctttagga tgcgctaaag 1188961 gagtgttgtg ttcaaaatca tatttttgtt gttctaacat atccttaact ttttcgtaac 1189021 caatctcgtt ggtaattgaa acattttctt tagtctcttt attagtagtg gctgcaaaaa 1189081 cttcatttgt tgacactaat ggtgacaatg atagacataa aactagtgaa gcaagtaatt 1189141 cttttttcat acgaaacctc caataaaatc taaatataag taatatttat catttacacc 1189201 aattgaaata tggcataaaa tacatgtaat aatataacat aaaaataaat acataaaaag 1189261 gtatcggagg aaaaaatgaa aaagaaaact aaaattatac tttctctctt ggcagcactt 1189321 attgttatat tgatagtact tccagttcta tctcctgttg tctttacagc ttcttcggaa 1189381 aaaggagcaa tcagacacga aatttataaa agaggatatc cctaccaaag ctactttgca 1189441 gttctccaga aaagagaagg agacaatgaa tctgggaatc tttattatgt aaattggcta 1189501 gattggaaag atgaaacagg gcaaactcct cacttatgct attcgaaaaa atcatcagat 1189561 ggtgaatacg aagtaagttg tggcacaggg ccgtaaaaat aaattttaaa attgaataag 1189621 tccaagacgg aaagcctgcg gacactgatc gttttacaga gaaatttgtg cttcgatcgg 1189681 tgtccgtttt ttttcgcaac taaccagatg tctatcgcga ttactagcta tgaaaggagt 1189741 aattagacat gaaacagtcc aaaaagaaac catcacagaa gcaacatgag cgcttagatc 1189801 gtttctggca acaaatgatg aacactaaca tgcaaacact cagacgtggc aaaggcggcg 1189861 cttataaacg cagaaagtaa aaagggagtt tgaggatgat gaaaaacgga ttcgcttata 1189921 aaaacggaaa gcttgtgaat atcttttgcg gcaaagaaga gctctataac gagttgaaag 1189981 ccttcttggt caaaaccttc agtatcaacg tgaaagaggt atcgaggccc tcaatatatc 1190041 gcagaacaaa aagcaaacaa ctggaatgac acttactcta tttaactatc aggagggaaa 1190101 gcactatgac agatcaaatg attgcatggg agattgagga atggattcgt gattataaat 1190161 tcatgctgcg ggagatcaaa aggctcaacc gtgtattaaa caaagtggat tttattagca 1190221 caaagctcac tgcaacatac ggggaggaag cgggcatgcc aaggggatca gcaggcgtca 1190281 gtcaggcaga attgcggcag atggaccgaa gagaaaggcg gcttcacaaa tatgaatcta 1190341 ttgtgcatta cctggacaat gcaatggaac acattgaaga agaaaagcac cgaatcgttt 1190401 acgattgcat gatggaaggc atgagctaca ctgctattgc aaaccacctt gattgctccc 1190461 gggataccat cagaaagatc aaaacagcca taatcggcaa catcgtcaat aaagtcaaag 1190521 aagccaactt tctgcaatat ttgaattcgt ttaaatcggc ggtgtaaaat ggggggcagg 1190581 atcggcgcgg cggattattc ctgcgtcacc accaatttca tacaatgagt aaaacctccc 1190641 agtggtaagc gaggatcaac tcaactggga ggtcttacat agtgaatcgg tgataaaaca 1190701 gcagcagtat tgcgtacatg ttaatatccc cgacaaaata tgtttttttc aacagattcg 1190761 ttcgacaaat tttgcaaatt gttaatcgat aacttttcat tcccgatatt aaaaatggga 1190821 gtgaattgta aaatgaaaaa acagaaaaat aataaaaaga agaatattga aaagcgaaat 1190881 attgaaaagc gaaatattga agagaagaat aatgaggact tagaagaact ggaaaatgcg 1190941 atttatactt atcacaaaaa ggagctactt gctttctttc ttgaaaaaac tcgaattggt 1191001 catgataagg aagaatacaa aaggttccaa tctcttcttt ataagttgga tattgaatgt 1191061 ttagaatttg ctatatcgag attttctcat atagatatta tccatgatca ttcaaaatat 1191121 gttccagcct ttatcccttt atttgcagca tatctcacca tgttctttaa tttttatgaa 1191181 aaacattggg gagctttatc ttttgctgct ggtacaattg ctgctattgt ttggataatt 1191241 gcagtagaaa gaaaacatag aaatcaagca atttctatta tgaaaatatt tgaacaagtc 1191301 aaagagagaa aagtgaaaga cagatctaaa gactgaaagg agaaaatatg aataaggata 1191361 aattaaggta tgcaatctta aaagaaattt ttgaaggtaa tacccctttg tcagaaaacg 1191421 atattggagt tactgaagat caatttgatg atgctgtgaa ctttttaaaa cgcgaagggt 1191481 atatcattgg ggtccattat tcagatgata gacctcattt atacaaatta ggacctgaac 1191541 tgacagagaa aggtgaaaac tacttgaaag agaatggaac atggtctaag gcctataaga 1191601 ccattaaaga gattaaagat tggattaaat aataagagca tcctgcgggg tgcttttttt 1191661 gttccctgta aactgcttcc ggtaagtctc aggatagaca attggcggtt aacggcttga 1191721 gcacggtggt ggtttagagg gaatatcttt tccaaaacaa cacgaatcag aagggggcgg 1191781 cggtgaatgt agatggccga aaagcacatt caggcgtata aggattacgt caaaggcatg 1191841 aaatacaagg accttgccga gaaatacggg gtgtcagtga acaccattaa atcgtggaag 1191901 cagcggcatg gttgggaaag gaaaaagggt gcacccattg aaaaaagtgt gcacacaaaa 1191961 aaaggcgggc aaccgggcaa caaaaatgca ttagggaaca atggcggcgc accacagaag 1192021 aatcaaaatg ctgtgactca cggctttttc tctaaattct tgccagaaga gacgcttgaa 1192081 atcatggaag agattcagga gcgttcgcca gctgatatga tatgggatca gatacagatt 1192141 caatatgcgg ccattcttcg ggcgcaaaag atcatgttcg tttctgataa ggaagaaatg 1192201 atcaaagagc tgaaaaagaa aaggtccctc atatctgagg tcagcgaaat tgaagatggg 1192261 cttgtcatta gttttagtac gtggtttcgc tacagacttt acagtgaaac aaacacctaa 1192321 cacatttcac attgcttcag attgccttca aacttgataa tataacttct aaaccttcct 1192381 ataaaatgaa ggttttttat ttgatttcaa tttttaaatc ctttacatac agcgattgat 1192441 taactcgagc aatcaatgtc gcagttatat ttatttttca agaaaatgtt ataatgaaaa 1192501 gccataaaat gatgggaggg ggaatttcga tgcattacat aacggcatgt ttaaaaatca 1192561 tcagtgataa agaccttaat gagataatga aggaattcaa aaaacttgag gaagaaacga 1192621 acaaagaaga gggttgtatt acattccatg cttatccgct tgagccatca gaacgtaaaa 1192681 taatgctttg ggagatttgg gaaaacgaag aagctgtgaa aatccatttc acaaaaaaac 1192741 acacaataga cgttcaaaaa caagaattaa cggaagtaga atggttaatg aaaagcaatg 1192801 tgaatgattg aaaggctctt taaaaagaga cattcaatga cttagtatca gccacttgtg 1192861 actaagtagt aaattgttgt ccaactctta ttttttctat ttaatatttt ttgagacgaa 1192921 aatgtttttt taagctgatt ttaaaatgta ttcaaagtca gctctgtttg atttaatgga 1192981 ttatattatt tggatagctt gttaccatca taatggagat actccttata aattggaggt 1193041 taaaataatg agtcattctc aagaaaaaat tgcactaatt acaggagcaa gcagtcaagg 1193101 ggatattggt acggctattt gtcgtaagtt agcctcacag ggtatacata tcttctttac 1193161 tcactggaat tctgatacgg cctggataga agaatttcaa caagaaattt tacgtatggg 1193221 tgtccgctgt gaggcaatga aaattgattt atcagatgca catgctgcat tcacaataca 1193281 tgaaaaaatt tcagataaat taggatatcc ttccatcctt attaataatg cagctcattc 1193341 cgcaagtgat aattatgtat cgttagatgc taaatcactt gatgagcatt atgcggttaa 1193401 tatgagatcg aattttcttc tttgtgttga attcgcccgt cggtttaaaa aatctaattt 1193461 aatatcagga agaatcatca atatgacatc agggcaggat ttaggtcctt tgcctgggga 1193521 gttagcgtat gcagcaacta aaggagctat ttctgcattt actaggtcgt tatcacaaga 1193581 acttgcacca ttgggcatca ctgttaacgc cgtaaaccca ggtccaacag attctacatg 1193641 gatgacagat gaaataagaa attttctttc acctaaattt ccaatggggc gtattggcac 1193701 accagatgat gcagcacgaa tgattgcctt tcttgcaagt gatgaggctg aatggataac 1193761 tggacaaatt attcattcag aaggtggatt tattcggggc taagctaatg aaacacggta 1193821 tacaccaatg tatgatgtat tcccaaaact aaatctaaac ttgaagcgaa aataaggtcc 1193881 cttctctttt tagaggggga ccttatttta ttcatgcatg ttttgcatcc agaaaatctg 1193941 gcggataaag attaataaac cgttacatat acttttccga atactgcagt acctttaaac 1194001 aaagtaatcg tggctttccc ttttgattta gccgtcacta aaccattttg atcgacttca 1194061 gcaacttttt ggttatcagt ccaataacga gtagctgaat tatttttaac agaataggtt 1194121 tctccaactt ttagaggtaa attatagtct tgaatcttga taacatgtgt aggtgaaata 1194181 gaaatgttct ttacttcagt aggtgtggag tttatttcat gagctgaagc taccccgctg 1194241 accgacagag ctaacgcaga aatcgataaa gcagaaacaa ccgttttttt gaaattcatt 1194301 ttgaaacact cctttaaagt tttttgtctt gcactataac aattcaataa aagtaattat 1194361 tttccttgta aataaatgtt aataatatgt gaacgatcaa ttgatttgag ctaagaatat 1194421 tgtgtgccct gcacagagtt tgtatttatg atggaaaatt gctgagagag aatggccatc 1194481 cttaaaatgt taatagcaca catttgatgg gtattagttt gttgagcgtg tggaaatttt 1194541 gttacctgca ctttatcccc gaagatacca aatcactttt cttcatcatg ttcttacttt 1194601 cgtactcata cattagaaaa tcttcgttct aaataggtga agaattggag tatttttatg 1194661 aatttctgct gaatatacat tacatagcaa actcaaagag tataaaaatc gcttttttcc 1194721 ggaagcttcg gtaaaaaacg aaacttttgt ctctatgatt ttgttttata atgtaaacgg 1194781 tttcttatat agtatactta tactatcaat ttgctcaagt agatactgac aggaaggata 1194841 gaaaaacaga tggaatacat aaatacaaga caaaaagaga ttttgtatct gttgttatct 1194901 gaacctgatg actatttagt tgtgcaagat ttcgcagata gggtacagtg ttctgaaaaa 1194961 acaatccgga atgatttgaa agtgatcgag gattatctca atgagcattc tcatgcacag 1195021 cttattcgaa aaccagggtt gggcgtttat ttacatatag aagaacagga aaggacctgg 1195081 ctaagccaac aattacatac tgaacatttt tcttctaggc agcggagcga taaggaaaga 1195141 atgctgcaca ttgcttatga cttattaatg aatccgaagc ctgtttccgc aaaagacatt 1195201 gccgctcggc attttgtcaa tcgatcttcc attaaaaagg atttatacgc agtagaagag 1195261 tggctgaagc gttttgatct cacactggtt tctaggcagc ggcttggatt aaaggttgaa 1195321 gggaacgaaa gaaataaaag aaaggcattg gcaagaatat ctgatttgat tcacaataca 1195381 gcgtttacca gccaatttat taaaagtaag tttttacatt atgaagtaga ctttgtgacg 1195441 aaagaaatca aatcactaca aaaaaagcat tccctctatt tcacagacga aacgtttgaa 1195501 agtttgttgc tgcatacatt gttaatggtc cgccgcatca aaatgaagca gccgatttca 1195561 ttgtccccaa aagaaatggc ggcagtaaaa aagaagaaag aatatcaatg gacatttgct 1195621 tgtttacagc ggcttgaacc ggtttttgca attcgcttcc ctgaagaaga agccgtgtac 1195681 ttaacattac atatattggg cggtaaggtt cgttatccat tgcagacaga agagaacctt 1195741 gaaaatgctg tgcttcctaa ggttgtaggg catttaatca atcgtgtttc agagctgaaa 1195801 atgatggatt ttcacaagga tcaggatttg atcaatggtt tgaacattca tctcaatact 1195861 gtgctacaac ggctgagcta cgatctttct gtagcaaatc ctatgctcaa tgacatcaaa 1195921 aagatgtacc cttatttgtt ccacctcatc attgatgttt tggaagacat caatcaaact 1195981 tttgatcttc atattcctga ggaagaggca gcatatttga cattgcattt tcaggcagcg 1196041 atcgaacgga tgcagggcag cagcgagaca cataaaaagg cggttatcgt ctgccacatg 1196101 gggattggga tgtcacaatt gctgcggaca aaaattgaac ggaaatatca ccaaatcgct 1196161 gtaatggctt gtattgcaaa ggccgattta aaggattata tcaaaaagca tgaggatatt 1196221 gatcttgtca tatccaccat tgcgctggag aatataacgg ttccccatat tgttgtgtct 1196281 ccgcttttag agcctggcga agagaagaaa ttaagtgcgt ttatacgtca gctgggcgaa 1196341 tcacaccgcc aaaaacaaaa aacgtttcag atgctgaaca atacgactcc ttttttggtt 1196401 tttttgcagc aggaggcgga gcatcgctac aagttaatcg aacagctggc gacagctttg 1196461 tttgagaaag gctatgttga taaggactat gcggttcatg cggtgatgag ggaaaaaatg 1196521 tcggctacaa atattgggtc aggcattgcc attcctcatg caaacgctaa atttattaaa 1196581 caatcagcaa tcgcgattgc cacattaaag gagccgcttg aatggggaaa tgaaaaagtt 1196641 tcgctcgttt ttatgctggc tgtcaaacac gaggatcaaa ctatgacaaa gcagctgttt 1196701 agcgagcttt catatcttag cgagcagccg gccttcgtcc agaagctgac gaaagaaacc 1196761 aatgtcatga catttttatc tcatttggat tattaaaagc agggattatt ccttgctttt 1196821 tttgttcatg gcagggcttg agaaataaat ttgcgagtga agacgcctat tctccagcaa 1196881 tgatctaaat aaaataagag tttaatagtt ggagaagaaa tgttacactc ttttctgtat 1196941 atggtaaaga atgaaaaaac acgattcggt tggtagtccg gatgcatgat tgagaatgtc 1197001 agtaaccttc ccctcctcgg gatgtccatc attctttaat atcttttatg aggagggaat 1197061 cgttatgaaa ttaacgattt actacgatgg tcagttttgg gtaggcgttg ttgaagttgt 1197121 ggacaatgga aagctaagag cctttcgtca tctttttggc aaagagccga gggattctga 1197181 agtattagag tttgttcata accaactttt gaatatgatg gcccaagctg agcaggaagg 1197241 agtgcgttta caaggcaggc gtcaaaaaaa gatcaatcca aaaagattgc agcgccaggt 1197301 ttcaaaagag ttgaaaaacg ccggagtaac ttctaaagct caagaggcga taaagctaga 1197361 gcttgaagca agaaagcaaa agaaaaaaca aataatgaaa gaacaacgag aacatgtaaa 1197421 agagcaaagg tatatgctca aaaagcaaaa agcgaaaaag aagcacagag gtaaataatc 1197481 caaacaaaag caggcgcagt gcctgctttt gtaattaagg actctacttt gtaacatata 1197541 tccaatgttt atactccgct gatttatgat tcaatataaa ccctaacttc tccaaggttt 1197601 tttgtgagcc tagattatca tgttcgcatc ttgcggtgat ccgggatact gtttctcggc 1197661 ttaatgccca gtttattagt ttttgggcgg cttccacaca ataacctttg cggcgatgac 1197721 ttttatttgt tgcaaaaccg atttcaatca tgccattttc gtctgggtca cctaaaaatc 1197781 cagttccccc aacaatttca taattgtcct tctttacaat aatccatgaa tcaaatcctt 1197841 ttgttccatt gtttttgact aaaatctcgc ggaaataagg tatcgcttca aaaaaatcag 1197901 aatttggcca ttcaccattt gtttcatagc ctaattcttt gatagcctga tgatcttgtt 1197961 tagacgcggc gtcaagaagg ggaatatcaa tcgtttgtaa tcgtaatcga ttcgtttcaa 1198021 ggagaaccat atatttaatc ctcttttctt tttactggga ataatgataa catataacaa 1198081 ttttctctgg taccttggca gtagagaaag atgaaaaaat tgagggggat tgaaagagtg 1198141 acaggtgaga gtttgcccag accaaaaacg ggtaggaaaa tgctgatgtt aatgtgtccc 1198201 tacccgtttt tctgttcctg aatgcagggt ttctgataac atgttgtgct accttttcgc 1198261 aatcaaataa agcgatatgg ctctttgggt ttgcacagga ttatgaatga taatgaccca 1198321 ttggtttctt cgtcttggaa agcttgctac cgcatacaat ggagcagtat cgcgcggagt 1198381 gaacccacca tttatcacgt tgatatctct tccttcaaga tgacaaacta agtattcacc 1198441 tggattgatg acctgttggt tcgtccatgc gtaagaataa aagccgtctc caagatcttc 1198501 ggtggaagat ggggggacaa agccatctac agtcaatgtg atttctcttc ttcgctgtct 1198561 ttctgaaaag tctggacttc tttgagggtt atgagtatgt gaaaagtaag gaattaacgc 1198621 agggccataa aagtaatgat acaaagcaac cactccttta ttttccattc atacaaattg 1198681 tatgtgggag ttatttgttc attcctgttt tgttccatgt agactaataa tgggctatag 1198741 gcgtccaagg aaatcaattt gtccttccgt tgattcaatg ctagtaacct tgaaaatgca 1198801 ggttaggatg atagaattta catattactg caagaagtta gacatacatc attttgatag 1198861 tgggtgaaaa caatggcgaa aaaaatggca aaaacaaatg cggttcgtct gatagaacag 1198921 cagaacatct cttatgaggt attagggtat aaaacagacg gccagccggt agatggcatc 1198981 tctgttgcgg aaaaaatcgg ttattctttg aaatatgtat ataaaacgtt ggttgcagca 1199041 gcaggaacaa atcattatta tgtctttgtt gtacccgttg cagaagagtt agatgtaaaa 1199101 aaggcagcaa aggtgacagg ggaaaagaaa atagaaatga ttgcaatgaa ggagctgtta 1199161 gcggtaactg gctatcttcg cggcggctgc tcgccaattg gcatgaaaaa attgttcccg 1199221 acctatattg atgcatctgc agaaacgctt gattttatta ttgtcagtgc agggaaaatc 1199281 ggtatgcagc taaagttggc gccacaagat ttagccagat catgtgatgc cgcatttgca 1199341 gaaattgtat agatgcagat ataggggaac gaaaaagctt agtcatatcg attaagcttt 1199401 ttccgcatcc ctttcaaata tgatttcaaa ataagcagct gccccatacc catctatact 1199461 gggagcgaaa atctgaacga atctccagcc tcttttcgca taatcatgga tgatttgctg 1199521 gtagtcttct ttaggccttc ttctcatcgt actcagctca actcttacga attcatattc 1199581 tttcatcgtt tgatccctcc tattaaggta tacgtaaaat ggagcgagaa gttccgaaaa 1199641 cctaggttaa ggtcggaaag tatatttcac tcactaaaca aatccattta tgcctgatgc 1199701 ctgcatgcat ctgggaagag ttaaggggct ataaaaacga attttaccgg gtcagcagtc 1199761 caaatgaatc tcttgcttat tgcatttgac tgagtatata agtaaaaaaa gagcggccag 1199821 aacatataag aaggagatga tcattaacgc actcataaca gggtagtgtt tagcggagta 1199881 gatgaaaaaa tcaagctgtg aaatttgttt ggggctgctg acggcatcaa ttccattaag 1199941 cagttttgag agtttagcag tatagttcca atcaaatcga tctgaaacaa gctcgcttcc 1200001 ttgataccaa ttaacagcag ctaaaaacag aaataccata atagaaaatc caagctgaac 1200061 aactaaaaat attcccttca cttttgtatg acctccaaat ctatgaatat gggaaaatca 1200121 aacaatatat taccaccgta tgggttattc ttgcaatttc acttccatac aactcaaacg 1200181 caagtctatt tttttgtttg tttttggctt ataatacctg atgatggaaa aagagtgcgg 1200241 gtttatagat tagagaaaca aatgtatttc ttagcatttt ttatttgtgg agagagtata 1200301 gaagcattcg attagatctg ctttttcaca gaaacggttt tcatctgttt gcctgagctt 1200361 tacaattggc tggcaaaaaa acaatgattt ctttcaatca aaacatgcaa cgatgcgaca 1200421 cattttatat cttgatgact tatttcattg cctttaagtc atcctatcga gaaagcgatg 1200481 gtattttatg aacaaagaaa ccctaaaaaa catactcatg attttttcaa tatgcgcaac 1200541 actccgagaa accgatggta tgcgcatagc tgatagctgg attttgagtg agattatacg 1200601 atttttgatt tgcatggttg tgttttttgc catgacattt ctattagatg ctgtttttcc 1200661 aaacaaaaaa gagtcacatt aatgtgtggc tctttttgca tcatctgatc agaaacatca 1200721 taaatgaatc gatcatcatg atgaagaaca gcaagcaaaa ataaataagc gagtagacaa 1200781 acatatcctt tgcccacttc acgtcatcgt ctgttttgaa tcctttgatg ctttttttga 1200841 tccatatgcc tccgagaacc aaggcggcta agaaataaaa tgggcttata tggccggtgc 1200901 cgagagagaa aggaaataat agcgtgaccg gcaccaggac ggcaatatat tgcatcattt 1200961 ttatttttgt tacatgattg cctttgacta ctggcaagag cggaacgcca gcagcgcgat 1201021 attcctcttt gcgtcttatc ccaatcgccc aaaaatgcgg cggctgccac agaaacataa 1201081 tcgtgtacaa cagcactgct gtcatactga agtcaccggt tacggcacaa taccccatca 1201141 atggcggcgc agctcctggg aagctcccga caaatgtgct ccacacagac gttcgtttca 1201201 cccataccgt atagatgatc gcataaaaaa taaaggcggc cagtccgaga aaggccgtta 1201261 atggattgag ggaataaagc atggcaagac ctgcgattcc taaaacagag ccatatgtta 1201321 agatcatggc tggcggcatt ttccctgtga ccgaggccct gctgcgagtt cgtgccattt 1201381 ttgcgtccat atgccgatca aaatagttgt tatagacagt gccggaagcc atcacaaacg 1201441 cggttcccaa cattgctgtt accattgtca tcaaaaaagc caagccggtt aacgtttttt 1201501 ctgcgcttgc aaacgcgatc caaaacccgc cgaaggctgc tatcgagttt gatatgataa 1201561 tgcccggctt tgcaagtttg ataaaatcgt aaatggttac ccggttcgaa gcttttatgt 1201621 attttgtttc agatatggct gcagaatctc ttgtattctc caaaaataga cgcctccccc 1201681 aaaactgcat gcttttgtta tcgtaacaag agggggacag aatcacaatt atttcccata 1201741 tttgtcatga tattgtcatt tttaaaacaa aaaaatgggg agctggactg cccccatttt 1201801 gatatgtggc gactagtaac cgtaacctcc cccatatcct ccgccataac ctccgccgta 1201861 accgtaccaa gggtagtaag gcggtcgcgg gcgcgggtag taataaggcg ggcgcggata 1201921 aaacgggtag aacggataat acggtcttgg ataataataa ggcggataaa atggcggtct 1201981 cggacgcgga taataataag gctgtctttc atcataaggg gtaatttgtt caaatgactg 1202041 ttcattcaaa gggtaatcca agaggaaaac ctccctagct ttttttattc cttttaccat 1202101 attcctgatg cttaagttgg gtgtatgtac attcatgaaa ttcggttttt tttatgatga 1202161 aattccttaa aaaggattga catgaacttc taaatctcat agtattacaa atgtgaaata 1202221 aatgttacta caatgttaca aaaacatttc taaatagata cagttccaac tgatgaagag 1202281 taaatcgaaa tggctacgaa agaaggagtt tttgttgttg gcaaaaagaa tcaaatggtt 1202341 tcatgtatta atagcagttg tatgtgtggt gggccttatc ggctttttcc ataatcattc 1202401 attgaaaaaa gaaacggtca tgaataaagt aagaactgat tctcaatatg ggaatgttga 1202461 gatcgcaacg cttgtgaatg acgggaaaac ttttaattac gcggtaaact atcctgtttt 1202521 caaaaatgaa aaaatggatt cggcattaaa aagattcgca gaaaaagagg ttcgtcaatt 1202581 tcaaaaggaa acaaaggacg ttgaccaaga gcatacgaca aaacgcaacg aattaaatgt 1202641 tgattataaa attgtccatt atgccaaaca gacagtggcg attgtattta atgaatataa 1202701 atacatcggc ggggcacacg ggcaaaccgt gaaaaaaacg tttaactatg attttagtaa 1202761 acaagcgttt ctttccattg atgatatttt caaagaggac gctgactact tacataagct 1202821 ttcgttaatc gcttatcacg agctgaaaaa gaataaggac attgccgcgg acgatgcact 1202881 gttaaaggaa gggacggctc cgaaaaaaga aaatttcagc cgctttgcca tcaaggagga 1202941 ttatatcgaa ctttactttg acacatatca ggttgcagca ggctatcttg gagagcaatc 1203001 gattgccatt aagaaaagtc ttttgaaaga cattctgaaa gaacaatata ttgataaagc 1203061 aaaaaataaa aataaaatca aagaacaaaa gccgaagcat gaagtgattt ctttacccaa 1203121 agaggaaaca gttgatccaa atcaaaaagt cattgcgctt actttcgacg acggcccgaa 1203181 tcctgcgaca acaaatcaga ttctagactc cttgaagaaa tataagggtc atgccacgtt 1203241 ttttgttttg gggagcagag ttcaatatta tccggaaacg ctaataagaa tgctgaaaga 1203301 aggaaatgag gttgggaacc attcatggag ccatccgctt ctcacaaggc tttcagtgaa 1203361 agaagcgtta aagcagatca atgatacgca agacatcatt gaaaaaataa gcggatatcg 1203421 tccgacgctt gtaagacccc catacggcgg cattaatgat gaactgcgga gtcaaatgaa 1203481 aatggatgtt gcgttatggg atgttgaccc ggaagattgg aaagaccgta acaaaaaaac 1203541 aattgttgac cgtgtcatga atcaggcggg agatggaaga accattttga ttcacgatat 1203601 ttaccgcacc tctgctgatg cggccgatga aattataaaa aagctcaccg atcaaggcta 1203661 tcaattggtg acagtttctc agcttgaaga ggttaaaaaa caaagagaag cgaaataaat 1203721 tagaaaaggc tgtccgtacg gacagccttt tttctattta ataagagcct gtggtggccc 1203781 aaacatttaa gtttggtcct gaatacttgc cgaaagcgta agaagtcctt ggatctaaat 1203841 catataccat cggtgtatag caagactttt ggccggccac cgcttttcca ttgccgcctg 1203901 cagaatcaca attatatctt tttccgtctg tgttccgggt aatctccgca tttgcttcat 1203961 agccagacgt caatgtatta ttcatcgtga tttttgccca agccgtttta catgtactgc 1204021 tgaatttaag ctcgactact ccgatgactt gattgctggc attcactaag tttgaggatt 1204081 tttttgtaga gccgctggac gcacaatcat tgtaataagg gctttttcca tcgtaggcat 1204141 gggtttccgc cttggcgggt gcacctttga cggcaaaaac aaatactact gcgaataaca 1204201 ccaatgaagc cttcataaac agtcttttca atttatgacc tccttaatat ggcaaacaat 1204261 aaatcatatg gaggaacaat caaaacatgc atgctttttt gtgaacaata aaggcggccg 1204321 ggaggatgga gttcttggcc gcctctggta tgaggttatg cttttacatc aatggtttgt 1204381 ccgagagttg gatgttgaat catctttaag gtttgatcgg cattttgctg ggcggtgtcc 1204441 agcctttttt tcgttaaagc aatatttaca ttctgggcaa gggatgcttg atgcatcgca 1204501 accgataaag caggaatatc catggttcca cctcctatgc cttacctatc ggcgggtttg 1204561 tatgatttta cagtgaaaaa tggcttaatt tctcttgttg acccttacgc tgcggcatat 1204621 cgtatgtttt tgacaaggag ggaatcagga tgaatctagt aatggaaaag acctttgagc 1204681 aatacgaaaa gctgttttca atggaagaac agaaaagaga agatgtattt cggtatacga 1204741 tgatgaggcc gtttgaaaag atgtggaccg ccatccaagt tccgctgaaa gcgaaggagc 1204801 caaacggcta tgatgtgatc atggctgcga aaatgctggg ctatttggat gtccgtgatg 1204861 ctgaaagcgg ccagaaagca ctacaaatac tgaaagaatc acatgtttca gagacagctg 1204921 aatctgcact tcggcaatgc atattttttg ctgagcgcga acagctgcgg gtgaatgcaa 1204981 aggagatcaa attcggcctt tatatcgctg atccaaataa gcttcagctg caaaaaggct 1205041 actgcgggtt tggcgggata ccgggcttta ttcatgtatg gattaatccg aacagttata 1205101 acctgccaag gattccttcc attattgctc atgagtttca tcataatgtg cggttttcgt 1205161 atatagattt tcatcatggc tctgtaagtg tcggggatta tcttgtgatt gaaggattgg 1205221 cggaatcatt cgccagagag ctgtttggta cggaacgatt gggcccttgg gtaactcgtt 1205281 ttgatcatga agacttgcaa tattccattg atgtgattaa tgaggtgctg gatgtgaaag 1205341 gattttcgga agtcagccgt tatatgtttg gtgatccaat tgctaacgac caaggcttta 1205401 agcctgcagg tttatcggct tttgcgggtt atgcagttgg ctatcatgcc gttcagtcat 1205461 ttatgaatca acatcatatc acgataagcg aggccacacg tttggatgcg aagaccatta 1205521 tttctcaatg cggtctgttt tctacatgaa aaaagcgtca catacagcgg cgctttttga 1205581 ttcccaaaac cagcagttct atggcggcac aggcggcaat tccgattgta tatgcttcga 1205641 tatcgctcca taaaaaaccg taccctagta caagcccgcc aagagaagta tctctaatct 1205701 ggtcgatcca ttcggcatga tagagctggc tgaattcaat gacaaaacag aaagaaagac 1205761 tgataatgcc cgttatcatt gtcttcagct tccgaaatag aaatccgcat cccgtgaaga 1205821 tcatggcggc ccacaacgag tctcccagat aagtattgag ggtatcagga agaacactgg 1205881 agaatgctct ggatccaagc cccagcccaa tgatcagtat ggtgaaaact gcatatatcc 1205941 aacgatttcg cttcattgcg aattgatacc ccgtctctgc ttcatctccc tgtattgtaa 1206001 ggaatatagc ttttatttgt ccactaaaaa agcggctgaa tagccgcgta gggtgtttat 1206061 tttgctttta ggtttacatg gtcggctgtc tgatccgtgc ctattacaaa atggagttca 1206121 tagcggcctg tatcatatac ataatcgatt tcatcggtaa acgggacggt taacacccga 1206181 tttactggtc ctaattgctt ctgcagcact tccggcgtaa ctccgcctaa attcagctgc 1206241 cgttccacac cggttccaaa gtagcggatt tctgaaattg tcatgtcttt atgataggaa 1206301 aatccgtagc ccggctgtcc catattccag tgatataaat caaatcgatt gtctcccccg 1206361 actggtcttt ccggttcccc aaacgcagcg tggacatccc cttttgtgct tttgttaatg 1206421 gtaaggcctt gcgcctgctg aggcatttcc cctttatagg cggtgttata gaggtttttg 1206481 acaagctcag cggctgattg attcgtgttt tctgagagtg tgtttgtttg agctgcggcc 1206541 tttgccggtg ctgaaaagga cgcagcccca aagccggtaa aacagcttgt tactgctgct 1206601 gccgcggtta tagcagacat tgtctttttc atgttaatcc ctcctaattg atctaccatt 1206661 ccgtttcccc gtgtttttgc aacgaaacat gtgagtgcgc tttgtatgtt ttattgagtt 1206721 gttgtaaggg aactgaaata ggtaattcgg tatataaagc aagaaagggg aatggagatg 1206781 gctggcaaga aaacaatcac aataaacggc gttgaaatgg aagcgtccga ggaacagacg 1206841 gtgctgcagc ttttgaataa cagctcgatt gaagtgccgc aagtttgcta tcatccaagc 1206901 ttagggccga ttgagacatg tgatacgtgc atcgtcagca tcaatggtga gctgaagagg 1206961 tcgtgctccg ctgaattaaa ggatggggat gtcattgata cgctctcacc tgacgtgaaa 1207021 aaagcgcagg tcatcgggat ggacaagatt ttatataatc atgagcttta ttgtacagtt 1207081 tgcgattaca acaatggggg atgcgaaata cataatacgg tgaaggaaat gaaaatcaat 1207141 caccaaagca ttccgtttga tcacaagcca taccataagg atgaatccca tccgttttat 1207201 cggtatgatc cagatcaatg tatattgtgc ggacgctgtg ttgaggcatg ccaagacgtt 1207261 caggtaactg aaacgctgac cattgactgg gagcggaaac gcccgcgcgt catttgggat 1207321 aacgacgtgc cgatcaatga gtcgtcatgt gtgtcatgcg gccattgttc aacggtctgt 1207381 ccgtgcaacg cgatgatgga aaaaggaatg gaaggggaag ccggatattt aacaggcatc 1207441 aataacgaaa cgctgcgacc gatgatcgag atcacgaaag gcgtagagac aggctacggc 1207501 tcgattctcg cgatttctga tatggaatcg gccatgcgtg atgaacgaat caaaaaaacg 1207561 aaaaccgtct gcacgtattg cggcgtcggc tgcagctttg atgtctggac aaagggcaga 1207621 gacattctga aagtagagcc gcaggaggaa gcgcctgcca acggcatttc tacttgtgtg 1207681 aaaggcaagt tcggctggga tttcgttaac agcgaagaac gcctgacaaa gccgctgatc 1207741 cgtgaaggcg atcatttccg tgaagcagag tgggaggagg cgttattgct gatcgccagc 1207801 aagttcactg aattaaaaga ggcgtttggc ccggattctc tcgcttttat tacatcttct 1207861 aaatgtacaa atgaagaatc ctatcttatg caaaagctgg ccagaggggt cattggcaca 1207921 aataatgtgg acaactgctc tcgctattgc caatctcctg cgactgccgg cctgttccgg 1207981 acagtcggct atggcggtga ttcaggatca attacagata tcgcgcaagc ggaccttgtt 1208041 ttgattatcg gttcgaacac gtctgagtcg catccagtct tatccactcg gattaaacgg 1208101 gctcataagc tgagagggca gaaagtgatc gtcgcggata tcagaaagca cgaaatggca 1208161 gagcgctcag atttatttgt ccagccgcgt gccggatcgg atatcgtctg gctgaatgcg 1208221 atcgccaaat atttaataga aaacggcaag gccgatgaac gatttttgag agaaagagtg 1208281 aacggacggg atgaatatgt aaaaagcctc gcgccgtaca cacttgaata tgctgaggag 1208341 aaaaccggga ttgatcaaga aacccttatc caaatggcag agatgatcgg gcaagctgac 1208401 agtgtgtgcg cattgtgggc gatgggcgtg acacagcata ttggaggaag cgacacgagc 1208461 acggcgatct ctaatctgct gcttgtgaca ggaaactacg gaaaaccggg agcaggttct 1208521 tacccattgc gcggccataa caacgtgcag ggagcaagtg actttgggag tatgcctgac 1208581 agactaccgg gctatgaaaa agtgacggac gaacaagtcc gccaaaaata cgagcgtgtg 1208641 tggggtgtgc cgctgccgaa ggagccgggt atgaccaacc acgaaatgat tgaaaaaatc 1208701 cattccggac agttgaaagc gatgtatgta aaaggtgaag aaatgggcct tgtcgactcc 1208761 aatatcaatc atgtacacgc tgcatatgaa aagcttgatt tctttgtggt gcaggacatt 1208821 ttcctttcac gtacagcgga gtttgctgat gtggttcttc ctgcgagccc gagccttgaa 1208881 aaagaaggaa cgtttacaaa cacagaacgc cggattcagc gtttgtatca ggtatttgaa 1208941 ccgctgggtg aatcaaagcc ggattggcag attattatgg aggttgccaa taagcttggc 1209001 gccggctggc tctatgagca tcctgcagac attatggagg aagcagccaa gctgtcgccg 1209061 atttatgccg gtgtcaccta tgaacgtctt gagggctata attccctgca atggcctgta 1209121 aacgctgatg gaaaggattc gcctttactc tttacagagc gcttcccttt cccagacggc 1209181 aaggccattc tctaccctgt ccagtggaca gagcctaagg aattcggtga ggaatatgat 1209241 atccatgtca acaatgggcg gctcttggag cacttccacg aagggaacct gacttacaaa 1209301 tcaaaaggga tttcggagaa aacaccggaa gtgttcttag aaatttctcc tgagcttgcg 1209361 gcagaacgag ggattcagga cggaaccctc gtcagactca catcgccttt cggaaatgtc 1209421 aaagtgaagt gcctgattac tgatcgagtc aaagggaagg aagtatatct gccaatgaac 1209481 gattcagggg aagcggcgat caacctgtta acaggcagcc atgccgataa ggataccgat 1209541 acgcctgctt acaaagaaac atcggccaag atggaaattt tgaagcacga cggaatcagc 1209601 ccgctgccta agatcaacca ccgcaacggc aatccgcagc cgcaaatcgg tgtgcaggtt 1209661 cataagaaat gggcgcggaa ggattatatt ttccctggtg acgctgtgaa aagggggatg 1209721 ggccataatg gctaaagcga ttaaacgaat ccaaaaaatc gaggtaacag aagaggatca 1209781 gcgaaagcgt gatttgcggg aaattgaaga tgctctaatt gaccacaaag aagcgattct 1209841 cgaaacattg catatgctgg gccatatgaa cgagcgcggg gtcctgccgt tgctccgcgg 1209901 cctttttggt caaggggata aagttcttga tatcctggtg aaaaaggcag atacagagga 1209961 aacagccaat acgctgaaaa atctgcttct tctgtttgga acactcggca tgctggacgt 1210021 gaagcagctg gagcctctca ttttgaaagt gaatgcgggt gtggcaagcg ctgtagagca 1210081 gaaaaacagt gaagaaaaga caggttattt tgatattatc cgctcgctaa aagacccgga 1210141 aatcaacaaa tcaattacac tgctcttttc ctttttaaaa ggaatgggac aagatacaaa 1210201 ggagctggaa cgcacgacgc agcctccgga acaccaaaaa catcatcagg aaccccgaga 1210261 gaaaagagga atgaataagc gagattgacc tcccacccga gcggcttcag ccagctcggg 1210321 ttttttgatg aaaaggtcta atggactagt aaaaaatatt caaatactag gaagaagtaa 1210381 gattgtgatg aatgagatag aaataatcgt tactttctta cctgttaaga aaagggaaaa 1210441 tctgattata atagaaatcg attactttag atgggggaac aatcatgaaa aaagtcttat 1210501 tactattatt tgtcttgacg atcgggttag cgctttctgc gtgcagccaa tcgagcgatg 1210561 cgtcagagaa ggaaaaaccg aaagagaaaa aatcgcaaga agagcttgaa aaggaacttg 1210621 ataaggaatt gaaaaaaggc ggtgagccga agaccaaaaa agatgatcaa atacataaaa 1210681 taggagaaac atttaaagca ggacatacga attttacagt gaataaagtt gatagagtgc 1210741 aaaaaggtga atatatgaat gttggcggag ctgtaaatga ggagacaaaa acaataaaag 1210801 atgatgagga acggcttatt atagaagtta cgatggaaaa tataggggaa gattcaataa 1210861 gctacaattt tatcgggttt gatttaagag ataagaatga tcaatcagtg cggcctgttt 1210921 tttctataga agagaagggc agaatcctta tgggaggaac actagtatcg gggaaaaagg 1210981 ttacaggtgt actcagttat gtcatcccta aaggagaaca gaaacattac acactggtat 1211041 ataatccgtt tttagctgat acaaatagca gtaatacaga agagagagta aaggacgata 1211101 ttgattactt ggtgaagtta gattagatgc taatttacag ttgcacgttt ttcatctgtg 1211161 gaaaacgtgc attttttata gcgaaacttg acttgaaagg atgagtgata aaagtgcaaa 1211221 ccaaatggct ggaacgggca cagcggattc gggcgatcgc ccaagcgggg cttgcttttt 1211281 ccaaggatgt gtacgacagg gagaggtacg aagagctaat gaagcttagc gcggaaatga 1211341 tggcggatta ctcggagaag gacattgaag ttatcactga tttatggcaa ggcgagaagg 1211401 gctatccaac accgaaagcg gatgttcgcg gcgctgtatt cagagagaat cagattttgc 1211461 ttgtccggga gaagcatgat gagctgtggt cgctgccggg cggattttgc gagattggtt 1211521 tatcgccggc tgaaaacgtt gtcaaggaaa tcaaagaaga gtcggggtac gatacagagc 1211581 cgtctcgatt gctggccgtg ctagacagcc ataaacactc tcatccccct cagccttatc 1211641 actattataa aatcttcatc gcatgcagca tgacggacgg gcagggggaa acagggatcg 1211701 agacgaatca tgccgctttt tttccggaag acagactccc gccgctttct cctaaacgaa 1211761 acacaccctc acagcttagc atgctgtttg actttttgcg ccatccggac aagaaaacga 1211821 tatttgacta aaaaagaaag agcctgtggg ctctttcttt tttataatgt aatgtgtttt 1211881 tcgttggcga gtttcagaag ggtcaaaata gaatcggctt gtttatggcc gagtttttgc 1211941 tttaatttgt tttcttcaac taatcggctg ccataaattt tgacggaggc tttgtcgacg 1212001 acagtatgcc agttttcctg tttttttccc tcaacaagcg gtttttcatg tctctcagaa 1212061 aaagagaaca caaagagtac gaatgcaagt gaaagtagga ttccgacaac ttgttttttg 1212121 taatcagtct gtgctgccac gttgttctct ccttcacctt ttaccttcta tttaatcata 1212181 gaaccaaatt attttacata atgggaaagt catttttgga gttagtgcat ttggttgaaa 1212241 acagagacgt tttttgagcg gagcggtgca attgaatcca tattggattt gcgtgcttat 1212301 gcctaaggtc acgttgtgag ccaaaacagc agtgcagaat agaaaaaaat tgaaagatta 1212361 tggtaagatg aacgaaattc gagggggaat atatgatgcc tgcatcgaac atcgtgatcg 1212421 cctgcctgct gttatcaatt taattatttg tggtagtccc tctctttttc gaaagcggga 1212481 ggtgaagtgg aacattaatt gctgaattct ttcaagggga gtgaccgtac atgaatgtgt 1212541 taaaccgccg gcaagccttg cagcgagcgc tgctcaatgg gaaaaacaaa caggatgcgt 1212601 atcatccgtt tccatggtat gaatcgatga gaaaggatgc gcctgtttcc tttgatgaag 1212661 aaaaccaagt gtggagcgtt tttctttatg atgatgtcaa aaaagttgtt ggggataaag 1212721 agttgttttc cagttgcatg ccgcagcaga caagctctat tggaaattcc atcattaaca 1212781 tggacccgcc gaagcataca aaaatccgtt cagtcgtgaa caaagccttt actccgcgcg 1212841 tgatgaagca atgggaaccg agaattcaag aaatcacaga tgaactgatt caaaaatttc 1212901 aggggcgcag tgagtttgac cttgttcacg atttttcata cccgcttccg gttattgtga 1212961 tatctgagct gctgggagtg ccttcagcgc atatggaaca gtttaaagca tggtctgatc 1213021 ttctggtcag tacaccgaag gataaaagtg aagaagctga aaaagccttt ttggaagaac 1213081 gagataagtg tgaggaagaa ctggccgcgt tttttgccgg catcatagaa gaaaagcgaa 1213141 acaaaccgga acaggatatt atttctattt tagtggaagc ggaagaaaca ggcgagaagc 1213201 tgtccggtga agagctgatt ccgttttgca cgctgctgct ggtggccgga aatgaaacca 1213261 ctacaaacct gatttcaaat gcgatgtaca gcatattaga aacgccaggc gtttacgagg 1213321 aactgcgcag ccatcctgaa ctgatgcctc aggcagtgga ggaagccttg cgtttcagag 1213381 cgccggcccc ggttttgagg cgcattgcca agcgggatac ggagatcggg gggcacctga 1213441 ttaaagaagg tgatatggtt ttggcgtttg tggcatcggc aaatcgtgat gaagcaaagt 1213501 ttgacagacc gcacatgttt gatatccgcc gccatcccaa tccgcatatt gcgtttggcc 1213561 acggcatcca tttttgcctt ggggccccgc ttgcccgtct tgaagcaaat atcgcgttaa 1213621 cgtctttgat ttctgctttt cctcatatgg agtgcgtcag tatcactccg attgaaaaca 1213681 gtgtgatata cggattaaag agcttccgtg tgaaaatgta atagataagg agactggaga 1213741 ttcatgaaaa agtaccatat ttcgatgatc aatatcccgg cgtacggaca tgtcaatcct 1213801 acgcttgctt tagtagagaa gctttgtgag aaagggcacc gtgtcacgta cgcgacgact 1213861 gaggagtttg cgcccgctgt tcagcaagcc ggtggagaag cattgatcta tcatacatcc 1213921 ttgaatattg atcctaagca aatcagggag atgatggaaa agaatgacgc gcccctcagc 1213981 cttttgaaag aatcactcag cattctgccg cagcttgagg agttatataa ggatgatcag 1214041 cctgatctga tcatctatga ctttgttgcg ctggctggta aattgtttgc tgaaaagctt 1214101 aatgttccgg tcattaagct ctgttcgtca tatgcccaaa atgaatcctt tcagttagga 1214161 aatgaagaca tgctgaaaaa aataagagaa gcagaggctg aatttaaagc ctacttggag 1214221 caagagaagt tgccggctgt ttcatttgaa cagttagctg tgccggaagc attaaatatt 1214281 gtctttatgc cgaagtcttt tcagattcag catgagacgt tcgatgaccg tttctgtttt 1214341 gtcggcccct ctctcggaga acggaaggaa aaagaaagcc tgttgattga caaggatgat 1214401 cgcccgctta tgctgatttc tttgggtacg gcgtttaacg catggccgga attttacaag 1214461 atgtgcatca aggcatttcg ggattcttca tggcaagtga tcatgtcggt tgggaaaacg 1214521 attgatccag aaagcttgga ggatattcct gctaacttta ccattcgcca aagtgtgccg 1214581 cagcttgagg tgttagagaa agctgatttg ttcatctctc atggcgggat gaacagtacg 1214641 atggaagcga tgaacgcagg tgtgccgctt gtcgtcattc cgcaaatgta tgagcaggag 1214701 ctcactgcaa atcgggttga tgaattaggc cttggcgttt atttgccgaa agaggaagtg 1214761 actgtttcca gcctgcagga agcggttcag gctgtatcca gtgatcaaga gctgctcagc 1214821 cgcgtcaaga atatgcaaaa ggatgtaaaa gaagctggcg gagcggagcg tgcggcagct 1214881 gagattgaag cgtttatgaa aaaatccgct gtcccgcagt aaaaacataa aaaccgaaat 1214941 caatttgatt tcggttttct gtttaaatat tttttttcat cccgcatctc cggcattctc 1215001 taagaaattt tccgcctttt acagagcttt tgaacagtgt gtaatcacag ttgtcgcagc 1215061 gcccgctgcg ggcatccgga tattcattga attcgtaaac aatcgatgta tcgtagcctt 1215121 ttgtttcata ttcttctttt ttggtttcca tgtcgatcct ccgttacaag acgtgtctgc 1215181 tgtttatctt acagcaagct tccggcgtat tcaatggatt ttaggaggtt gggtttatct 1215241 tgatttctcc cttggtttgc gccaaaatag ctttattaag cttatataca taaaaagcct 1215301 atgcaaagag gagaggaaac gggtatggga aaagggttac ttggaaaacg cgtggcaatc 1215361 ggtggctcac gaaaaacgga agaaattagt acaatcattg aaaaacaggg cggaatacct 1215421 gtcatccggc ctctccaagg tacagtttac ttagcagaga agcaggtgga gccggatttg 1215481 cggacgtttg cggaagaaaa agctgactgg gtcattttca cgacaggcat cgggttggag 1215541 actcttgtcg atatggcaga gaaaattgga ctgaaagatg agtttctgca ggccattcgc 1215601 caagcgaaag cggcatgccg gggatacaaa acgctgtctg cgctgaaaaa gcttggaatc 1215661 acaccggaag cttcggatga agacgggaca acaagaggct taatccgttc cttggagcct 1215721 cacgactttt caggaaaaac agtcatggtg cagcttcatg gcgaaaaagc gccggctctc 1215781 atggcatttc ttgaagaaaa aggcgcgtct gtcctgccga ttctgcctta tcagcacatc 1215841 ccgccggagg aggaaacggt ggagcggtta tgccgagagc tgatgaacga tgaggtcgat 1215901 gccgtttgtt ttacaacggc cattcaggtt cgttccctgt ttgattttgc caaggggcga 1215961 ggttatatca atgaagtgaa gaaggtattc gaagaacgcg ccatcgcagc tgctgtcgga 1216021 aaagtgactg ctgaagcact gcgggaagag ggcattacga gactgcttgc gccagagatt 1216081 gagcggatgg gtgcgatgat tgttgagctg gccaagtatt atgaagaaaa ggaataacaa 1216141 gtacaaaaag ccgcttttcc ctcggaaagc ggcttttgtc tgtcattcat tttgcttcag 1216201 ctgctgatga acggtgaata atgatgggta tgtcagcacg cttaagatta cacaagtcag 1216261 cgcggctgag gccatcgttg taaacacgat taagagttga aagcgtactg cctgaatcgg 1216321 gtccgcgccg gctagaatct ggccagtcat catgccggga agctggacaa gacccagtgt 1216381 tttctggctt tcgagcgtcg ggatcatact cattttcatc gctgaggtaa gaatgcgctg 1216441 tatggattgc ttcggtgtgc cgccaagtga caatattaat tgaatttctt ctttgcgaac 1216501 gccgacttct gagttaagcc ggtttagaaa caaacttgag agcaccatcg aatttccgat 1216561 gaccatcccg ctgatcggaa tgacatatcg tgccgtaagc ggaatgatat gaagagacag 1216621 cagaattccc tgcgtcacaa tttctacgat tgctaacgcg gcaaacaccc tccaaaacga 1216681 accgatagta tttttctttc gcttgatgac attttgcgcc gccaccgcga gcattaacag 1216741 caccatcagc aggataaaaa cagggtggtc tccgcgaaaa atcagcgaca aaacataacc 1216801 gatgataagc agctgcaccg cggcccggat ggtggcgatg atcatgtctt tttctacacc 1216861 ggctttaaag gattttgata aaaacaaggc gatcaaaaca aagatcatcg ttaaagagag 1216921 agaaaggtaa tccattaccg agtgcctccc ttcaaaaatt ctttcgctgc ttcatgctgc 1216981 ggagcggaga aaaatgtgtc ggtttcagcg atttcaagca gccggccatc tgccataaac 1217041 caaatggtat cggctattcg ttttgcctgc tccatattat gagtgaccca catgactgtc 1217101 cattttttct cttgatgctg acgtttgatc agttcttcaa tctcaagagc agagaccggg 1217161 tccaaggccg atgtgatttc gtccaacaat agaatggagg aaggatttga gagcgttctg 1217221 gccagtgaca gtctttgccg ctgcccgccc gataagtctc tggcgcttct gtctaacaac 1217281 tctggcggca gccctgcaag cgaagccagc ttttcaggag agtacagctg ggattgatgc 1217341 agcctttgta caagacttaa attgtcacgc actgtcccgt cgagcacggg agccgattga 1217401 aacgcgaggg ctgccgttcg cctcagctca ttgacattcc attctctgac ttcctttccg 1217461 tatatgttga cttcgccgct gtcaggcgtt ctcattaaat tacacataga aaggagggtg 1217521 cttttgcctg agccggaagg gcctaaaacg gctacgattg caccctgttg aatgtctccg 1217581 gtgacatcct gcagcacatc ataggtttgt ccatcttgtt tatagctttt tctgactgat 1217641 ctgaaggaga tggctggtat gttttgtgtt tgatcgtttg cttccattac aataatcacc 1217701 tttcaatata agtaggctga cattatattt aactataacg tgaaacagat tccttttggt 1217761 agcacaaata aaggagaaca ggctttcacc cattctcctg cagatgctac gcagtcagat 1217821 ttgactgtgc tttctttttc ggttttctcg gctgtgaagc gaaggtatgt aacatcatcc 1217881 ccgctattat aatgaacaaa ccggcaaatg ataatagaga tgggaaaacg cctgacagca 1217941 gaacaatttc accaagcagc gcgaaaatca cttcaccgga ttgagtggct tcaacagctg 1218001 cgagtttttg cggattgtct cttaccatat cagtggccca gaaaaataaa accgtcgcaa 1218061 tgatgcctga gctgacggca acgataaagg attgaacggt ttgacttgct gttggaaggc 1218121 catctgacca ccagccgtaa gctgctaata taagccagaa tggaaggctt gccaatgtca 1218181 ttccaagcac gcgctgaaat gtatcaagcc ggcctccgta ttcttcgagc attcttcggt 1218241 ttcctaacgg ataggcaaaa gccgcaatga caaccggcag cacactgaaa agcagcatcc 1218301 tcccagaaag cgattctgca tgctgaagct gaatcagagc cgctccaatc aggatgatca 1218361 cagaagtgcc aagtgaaacc aggggaatct tttggcgaat gagctgcgga ccgcccggca 1218421 tatcttgttt gacataaaac aaaggagata agagcacccc ggctacaatt gtaatttgcc 1218481 aggttccagc tatgagccac cccggaccgt atgcagccgc aaatgtaatc ggtgcgtaaa 1218541 aaagcacgaa accgacgaag ctccatttga tccaataaaa cggctttttc ctcatttcta 1218601 gtaagagagg cgtgaatgtc cctctcatga tgacaatcaa acataaaaat ggcaccataa 1218661 aaataaagcg cagcgaagag ctccaaagcc agctgcctcc tgataactcc atcgctctgt 1218721 ttaatataaa ggtaacggcg aaaaagagtg aagccaatat tccgataacg atagctttca 1218781 tgatatccct cattctggca ttattttttt atactatact attcggtatc atgcagatca 1218841 atggaatcat gagaaaaaca tcatgtttgg cgaaccgcta tatgtggaag acaaaaaagg 1218901 gaggtgaaat tgatggaaag agagacacag acatacttct ttccggatga cggcaggatt 1218961 ccgaatcacc ctgattttcc gctcgtggtg tatcaaaacg cgcttaagga caccggactg 1219021 gcagagcgga tcgtcacccg gcatggctgg tcaaacagct ggtcagggag tgtttttcca 1219081 taccatcatt atcacagcaa tacgcatgaa gtcctgattg cccttaggag agaggctgtg 1219141 attcagtttg ggggagaaaa aggggctgcc atccctttca aatcaggcga cgcagtcgtg 1219201 attccagccg gagtcggaca taaaaagctc agctcaagcc ccgattttac tgtccttggc 1219261 gcctatcccg gtggcgttca gtacgatatg aagacgggga agccgaatga gcgggaggaa 1219321 gcggtcaaac agattaagca ggcggcgttg ccggcgaatg atccgatcac aggaaaaaga 1219381 gagcctctat tggaaatatg ggtaaagtga aggggagaaa ttgctggatt gtcaataact 1219441 agtgccgcag aaacgatatg acatgagctc catataaatt aatttcataa tcgaagcaat 1219501 tcacgttcaa attttgttca aaaagtgtta tcatatagaa ggtaatcgaa ttggagtttt 1219561 ttgtgtttgc tattttcaga gagagtaaag gattttgact tattcaattg tttattttta 1219621 gataaaaata atactgaata tggcaagatg aaaaactggg tagtaaacat ttatttttgt 1219681 aaatgattgt gcatgaattc acaatcctta ttcttatgcc ttaaaagcgt gagacaggga 1219741 gaggcactac cctttccaaa aaaatcagca aactgcttat agtaaaggag aattggatat 1219801 gccagaaaca atcgatcaaa caaatgcgtc tgtcagccaa agccagcaag atcttattga 1219861 tcagctatta aagccagaag ttcaagaatc attgactgtt ttagttgacc agcttccgaa 1219921 gctgactgag ttagtgaata ttttaacgaa gtcttatgat ttcgctcagt ctgtagcgac 1219981 tgacgaagtg ttaaagagcg acacagtcgg tgcgatcact gaaattctcg agcctgtaaa 1220041 agaaacagcg aaagaagtag ctgcgactgc gatcgaagca aaagaccgcg cggaagcaag 1220101 caacgaaaca attggacttt tcggccttct tcgcatgctg aaagatcctc aagctcaaaa 1220161 gctgttccgt tttgctaaca gctaccttga agtcatgaac gaacgcgaaa accaaaaata 1220221 atctcagatt caaattgata taaaggacgg aggatatacg atgtcaaaac atattgtcat 1220281 tctaggcgct ggttatggcg gagttctttc tgctctaaca gttcgcaaac attacacaaa 1220341 agaacaagca cgcgtgacag tggtaaacaa atacccaact caccaaatca ttacggaatt 1220401 acaccgcctt gctgcaggca acgtgtctga aaaagcggtt gcaatgccat tagaaaaact 1220461 tttcaaaggc aaagacattg atcttaaaat tgcggaagta agctctttct ctgttgataa 1220521 aaaagaagtt gcgcttgctg acggttctac attaacttac gatgcgcttg ttgtaggtct 1220581 tggttctgta acggcttact tcggcatccc aggtcttgaa gaaaacagca tggtattgaa 1220641 atctgctgcc gatgcgaaca aagtcttcca acatgttgaa gatcgtgtgc gcgagtactc 1220701 taaaacgaaa aacgaagcag atgcaacaat ccttatcggc ggaggcggct taacaggtgt 1220761 tgagcttgtt ggtgagcttg ctgacatcat gccgaacctt gcgaaaaaat acggcgtaga 1220821 ccataaagaa atcaaattga aacttgttga agcaggtccg aagatccttc ctgttcttcc 1220881 ggatgatctt atcgagcgtg cgactgcaag ccttgaaaaa cgcggcgttg agttcttaac 1220941 aggtcttcct gttacaaatg tagaaggaaa cgtaatcgat ctgaaagacg gatctaaagt 1221001 tgttgccaac acatttgttt ggactggcgg cgtacaaggt aacccattag tcggtgaatc 1221061 aggcctagaa gtgaaccgcg gacgcgcgac tgtaaatgac ttcctgcaat ctacatctca 1221121 tgaagatgta ttcgttgctg gagacagcgc agtttacttc ggtccagacg gccgtccata 1221181 cccgccaact gcacaaatcg catggcaaat gggtgagctg atcggttaca acctattcgc 1221241 ttacctagaa ggcaaaacgc ttgaaacatt caagccagta aactctggta cacttgcaag 1221301 ccttggacgc aaagacgcgg ttgccatcat tggtgctaat tctacaccgc ttaaaggtct 1221361 tcctgcttcc ttgatgaaag aagcaagtaa tgtacgatat ttgacacata ttaaaggact 1221421 tttcagcctg gcttactaat ccttttaatg aatctggcat tgccaaaagc attcctttcc 1221481 gagtgctttc tggcaatgtc tttttttatg tttatgacag cgttaacatt tcattttcaa 1221541 aaaagagatt gatcccaaag gaatataaag gtaaaataaa aacaaatcaa aatgttaacg 1221601 ttaacatttt gaaatagaat gaaagacggt gaggacatgg aacccttcat gggcaaaaac 1221661 tttttattga aaaatgaaac cgctgtcagc ctctatcaca attatgcgaa agacatgcca 1221721 attattgatt accactgcca cttaagtccg aaagaaatct atgaaaataa gacatttcaa 1221781 aacatcacgg aagcctggct gtatggtgac cattataaat ggcgcatcat gagagccaat 1221841 ggaattgagg agacatacat taccggagat gcgcctgatg aggagaaatt tatggcttgg 1221901 gcgaaaaccg tgccgatggc gattggcaac ccgctctaca actggactca cttagaattg 1221961 cagcgttttt ttggcattta cgagatttta aacgagaagt ccgggtcggc tatatggaaa 1222021 cagacaaata aactgctcaa aggggaaggc ttcggggcaa gggatttaat cgtgaaatca 1222081 aatgtaaagg tcgtgtgcac cacagatgac cctgttgatt ctcttgaata ccatttattg 1222141 ttaaaagaag acaaagactt tcctgtcagt gtgctgcctg gatttcggcc ggataaagga 1222201 cttgagatca atcgtgaagg ctttcctgag tgggtgcagg cgcttgaaga tgccgctgcc 1222261 atatcgatta caacctatga tgagttttta aaggcgttgg aaaaacgagt gcgattcttc 1222321 cactcagccg gcggcagagt ttctgatcac gcgatagata caatggtatt tgccgaaaca 1222381 acaaaagaag aagctggacg gattttttct gacagattac aaggaacaga ggtttcttgt 1222441 gaagatgaga agaaatttaa gacatatacg cttcagtttc tttgcggttt gtatgcggag 1222501 ctcgattggg cgatgcagtt tcatatcaac gctttaagaa acacgaatac aaaaatgatg 1222561 aaaaggctcg gacctgatac agggtatgat tcaatgaacg atgaagaaat tgctaagcct 1222621 ttatacaagc tgctgaactc agttgagatg aagaaccagc tgccgaaaac gattttatat 1222681 tcactgaatc caaatgataa ctatgtcatc gccagcatga tcaacagttt tcaggacggt 1222741 attaccccgg gaaaaataca attcggcaca gcctggtggt ttaacgatac taaagacgga 1222801 atgctcgacc aaatgaaagc gttatcaaat gttggccttt tcagccgttt tatcggcatg 1222861 ctcaccgatt ccagaagctt tctttcgtat acgcgccacg aatatttcag gcggatcgtc 1222921 tgcaatttga ttggagaatg ggtggaaaac ggcgaagtgc cgcgcgatat ggagcttctg 1222981 ggaagcatcg ttcaggggat ttgctatgac aatgcgaaac actactttca atttcaagaa 1223041 gagaaagcaa acgtgtaaca aagtgtccgc tcagtatcgc tgagcggatc actatccgaa 1223101 aattcttaag acacagaggt ggaacatgcg aactgaactg gcaaataagg ttgtgtcggt 1223161 cgaaacggaa aaaaggcttt cattgaaaga gaaaatgtcc tatggctttg gtgattttgg 1223221 caacggtttt atgtttgatc tcggccagat ttatttattg aagtatttca ctgatgtagc 1223281 gggaatcccc gctgcgatgg ccggcggcat ttttttagtc agtaagctgt ttgcagcgat 1223341 aacagatcca attgtcggct catcaatcga ttatcgcaaa aacatcggca aacgggggaa 1223401 attcaggcct tatctattaa tcggcagcat cgtgcttgcg gtgcttactg ttcttatttt 1223461 tctgtctccc aatgtatcaa cgaccggaaa actgatatat gcatatgcat cctatatgat 1223521 ttggggcatc ggctattcgt ttgtgaatat tccgtacggc tcattagggg cagcgatgac 1223581 tcaaaattct gaggaccgga cctccatttc gacgttccgc caaatcggat cacttggcgc 1223641 cttgtttatc acaagtgtgg ccgtgatgcc gctgctcgtc aagtttgata atccgaaggt 1223701 cggctacccg gtggtcatgg gcttgttcgc cgcgctcggt gtgttttggt tttatatttg 1223761 ctaccgcaac tgcaaagagc gcattatcat atcggaagca cccaaagaaa aattaacact 1223821 ctcatctgtc gtcaaaacat ttattacaaa taaaccgctg ttaacccttg tcctgatgac 1223881 gattttttca atttccgcat acaacattaa atccgccatg ctcgtctatt tcgcacaata 1223941 taacttgggc aatgttgaat taatggctta tatgaacttc atcattattg gttcttcctt 1224001 tttgggcgtc gtattccttc caaagctcgt caagatgttt ggaaagaaac gaacggcaat 1224061 gatcggcttt ggcatcagtg tggccgcgga tctgatcaac tttatgcttc catctaacgt 1224121 ttatgtgttt acaattctcg ccagtatcgc ctttatcgga atcagtatcc caaatggcat 1224181 cacgtgggct cttgtctccg atattatcga ctatggcgaa tggaaatccg gtgaacggaa 1224241 ggaagcaacg acatattcac ttttcaattt ctcaagaaag cttgctcaat ctttgtctgg 1224301 ctttctctcg gggatcggtt tggggattat cggctatgtg ccgaatgcag tccagacagc 1224361 acaggcgctg attggcatca aagcgctgct tcttctgtat ccggccattg ctttggcatt 1224421 agcgatgttc attatcggct ttctttataa actcacagac cagcagcatg ctcagatcgt 1224481 tcaggatctt catcaaaaga gctgacaata taatataaag aatatttaaa ataatttgta 1224541 aataaaatgt gtttgtaggg gtttcgcttg gagagtgccc aaaaaactga aaaggaagga 1224601 ggcacttgct tgaaaacgat aacaattgca gctgaagaag caaaggaact cgtttggcaa 1224661 aagctggacg gtgccggttt gaatgaacga gatgctgaaa aagtggcaga tgttctcgtg 1224721 cacgctgatt tgcgcaatgt acattcgcat ggcgtgctgc acacagaaca ctatgtgaac 1224781 aggcttttag cgggagggat caatcctggg gcacagcctg tttttaaaga gacggggcct 1224841 gtgaccgggg tgcttgacgg agacgatggt ttcggtcatg tgaattgcga catggcgatg 1224901 gaccatgcaa ttgacatggc gaagaaaaaa ggagtcggca tggtcacggc cgtaaacagc 1224961 agccattgcg gagcgctaag ctattttgtg caaaaagcgg ctgacgaaaa gctgatcgga 1225021 atggcaatga cgcatacaga cagtatcgtt gtcccatttg gggggaggac tcctatttta 1225081 gggacaaatc cgattgctta cggagttccg gctaagcata aaaaaccgtt tatcctagat 1225141 atggcgacat ccaaagtggc ttttgggaag attctgcagg cccgtgaaga gggcaaagaa 1225201 attcctgaag gatggggagt cgatgaaaac ggagaagcag taactgatcc tgacaaggtc 1225261 gtctcacttt caacattcgg gggcccgaaa ggctatggac tatcgattgt agtggatgtg 1225321 ttttccggat tgctggcggg cgcggctttt ggccctcata ttgccaaaat gtacaacggc 1225381 cttgatcaaa aaagaaagct ggggcattac gtttgcgcga tcaatccatc cttttttact 1225441 gactgggata cgtttttaga gcagatggat gccatgattg atgaactgca gcaatcaccg 1225501 ccggctgttg gattcgaaag agtgtatgtg cccggcgaga tcgagcagct gcatgaagaa 1225561 agaaataaga aaaacggaat ttctatcgcc cggagcgtgt atgaattctt aaaaagcagg 1225621 tgagtaaaat gaaagcggtt caagtgcgaa aagcgtatga tctggtgaca gcggaggtga 1225681 agaagccagt tctttcaaag gatgatgaag tgctcgtgaa agtcaagcga gtcggcattt 1225741 gcggttcaga catgcacatt tatcatggaa cgaatccgct cgctaccctc ccgagagtca 1225801 tcggacacga ggtaacggga caagtggagg cagttggtgc gaatgtacag agcctaaaac 1225861 ccggtgatca tgtggtgatt gagccgattt cttattgcgg atcgtgctat gcctgccgca 1225921 aagggcggcc gaatgtttgc gccaagcttt ctgtatttgg cgtacatgag gacggaggca 1225981 tgcgggaata tattgtgctt ccggaaagac agcttcacgc ggtctcaaag gacttgcctt 1226041 gggaggaagc agtcatggcc gagccttata cgataggcgc ccaggcagtg tggagaggcc 1226101 aggtggaaaa aggtgatacc gtcctgatcc agggagcggg gcccatcggg atctgtgtgt 1226161 taaaaatggc aaaactggcg ggcgctgctg tcatgatgac tgacttgaac aacgagcggc 1226221 tggcatttgc gaaagaaaac ggcgccgatg ctgttgtaaa tgtccaagca gaacatgttg 1226281 ccgagcgggt ccttgaatgg actgggaatg aaggagcaaa cgtggtcatt gatgctgttt 1226341 gcctgccgga gacttttgca ctttcaattg aggctgtgtc accggcggga catgtggttg 1226401 tgcttggatt tgatgaaaga gcggctcaga tttctcagct gccaattaca aaaaaagaag 1226461 tcacgataac cggatcccga ttgcagacca atcagtttcc aaaagtggta gagcttttga 1226521 atggaggccg gttaatgcat aacgggctgg tgacccatac attttcagtt gatgacgttc 1226581 atcatgcatt tcagtttatt aaggagcatc cagatcaggt gcggaaagcc gtcatcacgt 1226641 ttgattaaat gactgaatcc ggaggtgcga gcatgaatat gacattccga tggtatggac 1226701 gaggcaacga tacagtcaca cttgaatacg tgaagcaaat tcccggtgtc aaaggcatcg 1226761 tttgggctct ccatcaaaag cccgtcggcg acgtgtggga aaaagaagaa atcagagccg 1226821 aaactgaata tattcaatcc tatggttttc atgctgaagt tgtagaaagc gtgaatgttc 1226881 acgaagcgat taaacttggg aacgaagaac gcggccggta tattgaaaac tacaagcaaa 1226941 cgatccgcaa ccttgccgga tttggcgtga aagtgatctg ctataatttt atgccggttt 1227001 ttgattggac acgcacggac atgttccggc cgctagaaga tggatcgacc gctctgtttt 1227061 ttgaaaaggc caaggtggaa agccttgatc ctcaagagct gattcggacg gtggaggaag 1227121 catccgacat gacactgccg gggtgggagc ccgaaaaatt ggctcggatc aaagagcttt 1227181 ttgctgccta cagaacggtc gatgaagaaa agctatggga caatttatca ttctttttgc 1227241 aggaaattct tcctgttgct gaggcctatg gtgttcaaat ggccattcat ccggatgacc 1227301 cgccgtggcc gattttcgga ctgccgcgca ttatcacagg agaggcaagc tataagaaac 1227361 tgcgggcgat atcagattca ccgtctaatt gtatcaccct ttgtacaggt tcaatgggag 1227421 ccaatcccgc taacgacatg gtggagatcg ctaaaacgta tgccggcatc gctccatttt 1227481 cacatattcg caatgtgaaa atttatgaga atggcgattt tattgaaaca tctcatttaa 1227541 caaaggatgg ttcgatcaac attcaaggcg tgatggaaga actgcataag caggattacg 1227601 aaggatatgt cagaccggat catgggcgcc atctttgggg cgagcaatgc cgcccgggat 1227661 atggcttata cgatcgggca cttggcatca tgtatttgaa cgggctgtgg gacgcttatg 1227721 aagcaatggc aaaaaaagag gtgggcatat gatcccgctg catgagaacc tggctggtaa 1227781 aacggctgtc atcactggcg gcagcggcgt gctttgctct gcgatggccc gggagctagc 1227841 ccgtcatggc atgaaggtgg cgattttgaa tcggacggct gaaaaaggcc aagcggtcgt 1227901 gaaggagata acggcggctg gcggcacagc gtgcgctgtt gctgcggatg tgctggacag 1227961 gatgtcactg gagcgggcaa aggaagacat ccttggccaa tttggcgctg ttgatctgtt 1228021 aattaacggg gctggcggca atcatcctga cgcgataacc gatgtggaga catatgaaga 1228081 agcgggagaa ggccaatcct tttttgatat ggatgagagg ggctttctaa ctgtattctc 1228141 caccaacttc accggtgcgt ttctggcctc gcaagtgttt ggtaaagaac tgctgaaggc 1228201 ggattcaccc gcgatcatca acctttcttc catgagtgct tattcaccta tgacgaaggt 1228261 tccggcatac agtgctgcga aagcatccat caataatttt acgatgtgga tggctgttca 1228321 ttttgccgaa accgggctgc gggtcaatgc gattgcccca ggcttctttc tgacaaaaca 1228381 aaatcatgat ctgctgatca accaagacgg aacgttcacc agccgatctc acaaaattat 1228441 tgcgggaaca ccgatgaagc gcttcggaaa accggaggat ttgctcggta cgctcctttg 1228501 gctggcggat gaatcctatt ccggttttgt cactgggatc accgttcctg tcgatggagg 1228561 atttatggct tattcaggtg tgtaacgaaa gcggtgcaac agaaactgaa ccaacatagg 1228621 ggtgaggttg agatgttttc aaaagataag cttcccgtta tccttttttt gttcctggca 1228681 ggggtgatta attacctgga tcgctcggcg ctttccattg cagctccttt tattcaggat 1228741 gatctcacat tgtctgccac acaaatgggc ttgattttca gcagtttttc gataggttat 1228801 gccattttta attttcttgg gggcgtggca tccgaccgct atggggcaaa gctgaccttg 1228861 tttgtcgcga tggttgtttg gtcgctgttt agcggagcag tcgccctcgc ttttggcttt 1228921 gtcagcctgc tgattatacg cattctcttc ggaatgggag aaggcccgct ttcggcgacc 1228981 atcaacaaga tggtgaacaa ctggttcccg ccgacccagc gggcgtccgt tatcggtgta 1229041 accaacagcg gcacgcccct cgggggagcc atttccggcc cgatagtcgg catgatcgca 1229101 gtggcgttca gctggaaggt atccttcgtt ctcattatga ttattggatt gatatgggca 1229161 gtgctctggt tcaagtttgt caaagaaaag ccgcaagaga cgatcaagga agcaccggca 1229221 ataaaagcag aaacgtctcc cggagaaaaa attccgctca ccttttacct gaagcaaaaa 1229281 acagtcctgt tcacggcgtt cgcttttttc gcttacaact acatcctctt cttctttttg 1229341 acatggtttc cgagctatct tgtcgacgag cggggattaa gtgttgaatc gatgagtgtc 1229401 atcacggtca taccgtggat tttaggattt atcgggctgg ctgcgggggg atttgtttct 1229461 gactatgtgt acaaaaaaac ggcccgaaaa ggtgtgctgt tctcgcgcaa ggttgtgctt 1229521 gtcacgtgtt tgttttcatc agctgtcctg attggttttg ccgggcttgt ggcaacgact 1229581 gcgggggctg tcactcttgt cgctctgtca gtgttctttc tttatttgac cggtgctatc 1229641 tattgggctg tcattcaaga tgtggttgat caaaacaatg tcggttctgt tggcggcttc 1229701 atgcatttcc tcgccaacac ggcaggaatt atcggcccgg ctttaaccgg atttattgtt 1229761 gaccaaacag gcacgttttc tggagcattt ttgcttgccg gtgggctggc tgtcttcgct 1229821 tcacttgctg tgattcgttt tgtccgtcca atcattggta agccagcggg aacagaagct 1229881 gagaatcctg tgtcttatta atctggaaat atagtgggag aggcggtatg tttgatgata 1229941 caatatacag taaataatcg cagccggtat gataaggaag ggaattagat ggtaaccata 1230001 aaagatatcg caaaactcgc aaacgtatcc cacactactg tttccagagc actcaacaac 1230061 agcccttaca tcaaagaaca tacgaagaaa aaaatattag agctagcaga gcagctcaac 1230121 tatacaccaa atgtaaatgc gaaaagtctg gcgatgcaaa agtcgcatac gatcgggcta 1230181 ttctttacaa gcattacaaa cggaacctca cacagcttct ttgcagacac tatcaaaggc 1230241 gtcaatcaag ccataagtga ggattacaat ctgtatgtgc gcggcattga tgatctgaaa 1230301 aactatgact ccgttacacc gatgagatat gacggcatca ttttaatgag ccaaagtgac 1230361 attgataatt cttttattta ccatattcgc gaaaaaaaca ttccgcttgt cgtgctgaat 1230421 cgtgatattg atgatcgtac catcacgaat attttgtcca atgacaagga aggctctcaa 1230481 gaagctgtag aatacttcat tcagtccgga catcaagaca tcgccatcat cgaggggatc 1230541 gaaggcttta aatcctccca gcagcgaaag gaagggtact tatccgcact gattcaacat 1230601 catattccga tcaagcatga atacagtgtc aaaggacagt acgatatgga aagcggcttt 1230661 caagcgatgg agcggctgct ggcactgccg aatcctccaa ccgctgtttt ttgttcgaat 1230721 gatgacatgg caatcggagc gatgaatgcg atattcgcaa agggcctgcg cgttcctgat 1230781 gatatttcgg tgatcgggtt tgatgatatt gggttttcac agtacatcac gccaaggctt 1230841 tcaacagtaa agcgcccagt ggagaaaata agcgtgctcg gtgcgcaaaa actcttgtcg 1230901 ctgatcagcg agcccgaaac aaaagcagaa aaaatcttgg aaaacacaga atttatggtg 1230961 cgtgattcag tcagacgatt gacgacgtga tgtcccgttt ttcagcgggc attctttata 1231021 cagaaaaatg ttaacgtgtg cataaagtga gagggaggca ataagggtgc agaagctgaa 1231081 taaaaatgtg tacgatcact atactcagta tccagaaaaa attctccaat tcggagaagg 1231141 aaactttctt cggggattta tcgattggca gattgatcaa ttgaatcaac acactgattt 1231201 taatgggagc gtggcagttg tccagccaag aggctcagaa aaaatcaaac gattaaatga 1231261 gcaagatgga ttatatacac tttttttaca aggaatgaaa gacggagaag cggtaaacga 1231321 gcatatgatt atcaactcaa tcagccgggg aattgacctg ttttctgatt atgaagcata 1231381 caaagaattg gcatcaagcg aaaggcttcg gtttattatc tccaacacca ctgaggctgg 1231441 gattgtatgt gatgaaaaag atcgtttaga ggataggccg caaaaaacat tccctgggaa 1231501 attaactgca tttctttact ttcgctatca ggcttttaaa ggagatcaga caaaagggtg 1231561 tgtcctgatc ccatgtgaac tgatcgagaa taacggtgaa aagctgaggg aaacggttct 1231621 tcattatgca catctgtgga agctggagga aggatttaca cagtggattc atgaggccaa 1231681 tacattttgt aatagtttag tagaccggat tgttccgggt tttcccgtcg acagcattga 1231741 tgagatcacg gcagatcttg gctatcagga tgatttgata gttgtgggag agcaatatta 1231801 tttgtgggtt atcgaggggc ctgattggat tggaaaagaa cttccctttg cggctgcagg 1231861 gctgcataca aagatcgtca gcgacctcac cccataccgg actaaaaaag taagaatttt 1231921 aaatggcgct catacagcaa tgacgccagt ggctttatta tacggcttga agactgttag 1231981 ggatgcagtc gagcatccgg aagtggggcg atttataaga gagctgattg atgacgaaat 1232041 tcttcctgtt ttaaaaatgg aaggtctttc tcagtatgct gacgatgtgc tgaaccgttt 1232101 taaaaacccg tatattaagc attacctgga aagcattgca ttgaacgcca tttccaaatt 1232161 caaaacgaga aacctgccga ctcttaagga atatgctgaa caaaagggac agcttcctga 1232221 acgcttggtg ttttctttca gcgctcttct gtatttttat catgataacg agacattgca 1232281 ggatgatccg gcagttcttc aatttttcaa agaggtttgg tgtcaggagg atggcgacat 1232341 gcttcggatt gcatcaagag tgttaggcga acagcggctg tggggggcag atctcaatga 1232401 gataccgaag ctgactgata gagtcgctgt ttacttgaat catattcatg agctgggcat 1232461 gcagagggct cttgaacaat actgcataca agggggagag gtacgttgaa gtcgtttata 1232521 aagattcata agcaagataa tgtccttctt gctctgcggg atattcaaaa gggagagagg 1232581 ctgcatgctt acggcgtgtc gattgaagta aaggatgata taaaaagagg ccataagatt 1232641 gcattgcagt ctatcaaaga aaacgacagc atcgtcaagt acgggtttcc aatcggtcat 1232701 gcatcacaag atatctcgat cggagagcat attcatgtcc ataatacgaa aacaaacctg 1232761 tctgatatcc aattatacag ctatacaccg agatttgatg aaaatccgta ttctaatgag 1232821 aaccggacgt ttaaaggttt tagaagagaa aacggagatg cgggtgtacg gaatgaattg 1232881 tggattgtcc caactgtcgg ctgtgtcaat ggaatagcag aaaaaatgct gcagcgtttt 1232941 gtcagagaaa caggggatat cgctccattt gataacgtac tggtgttaaa gcatcaatac 1233001 ggatgctcgc agcttggcga cgatcatgaa aatacgaagc agatcctgct gaatgccatt 1233061 cgccatccaa atgccggcgg cgtcttggtg ttagggcttg gctgtgaaaa caatgagctg 1233121 gcaagaatga aggaagcact gcaagatgtg aacttgaagc gggtgaagtt tctggaatcc 1233181 cagtcggtga ccgacgaaat ggaggcaggc gttgctttgc tgaaggaaat tcatgaagcg 1233241 gccaaaggag ataagagaga agacattccg ctgtctgaac tgaagatcgg gctgaaatgc 1233301 ggaggttcgg acggtttttc cggcataacc gcaaacccgc tgcttggacg tttttcagat 1233361 tatctcattg cacagggagg gagtactgtg ctgacggaag taccggaaat gttcggcgca 1233421 gaaaccatcc tgatgcagcg ggctgccaat gaagaagtgt ttcataagat agtcgattta 1233481 atcaatgatt tcaaacaata ctttattaaa catgatcagc cggtgtacga aaatccttca 1233541 ccgggcaaca aagcgggcgg catttctaca cttgaggata aatcgctggg ctgtacgcaa 1233601 aaagcgggga tttctcctgt cacggatgtc ttgaaatacg gtgaagtact caagacaaaa 1233661 gggctgactc ttttgagcgc accgggcaat gatttgatcg cctcctccgc attggcggct 1233721 gccggctgcc aaattgtcct ctttacaacg ggaagaggca cgccgtttgg cacctttgtc 1233781 ccgacggtga aagtagcgac aaacaccgag ctgtatgagg cgaagccgca ttggattgat 1233841 tttaacgcag gccttttagc agaggatgat gttcatgagg aatatgtgct gcgtgagttt 1233901 atccactata tgattgaggt ggcaagcggc cagcttgtga accatgaaaa aaatgatttc 1233961 aaagaactcg ccatttttaa atcgggtgtg acgttataat aagaaaaggc tatccttcaa 1234021 gcggatagcc ttcttcatta aatcaatttt aaaccgctga ctaaaataat ggaagccata 1234081 ataaattgca gtggacgcgg ggagaatcga ggcgaaagat ggctcccgat cagtacgccg 1234141 ggaattgaac cgaggagcag attagctgcc agcatgtaat ccacgcttcc gaagcttgcg 1234201 ttcaaaatgc ctgctgccgt aacaagaaga aaagcatgcg cgatatcggt tccgacaatc 1234261 tgtgacgctt tcatgttaaa taagtaaatc atggcgattg caaataatga gccggacccg 1234321 attgatgtta atccgacgat aaacccaaac acaacaccaa taagaattgt cagcgccctc 1234381 ttattttcaa gcggcatcag ctgccagcgg ttggggcgaa gttttctatc caaaaacaaa 1234441 cgaacgatga ttgaaatggc aaccagcgtt aacacatatc ctagagcgtg cttaataatt 1234501 tcttcctgat gctggtgaaa ggcggggaac aaatgcaata tgccaatggc tagcgaagca 1234561 ctcggaatac cgccgatggc taagtatttt accaatttaa agttaatcgt tttctgccgc 1234621 caatgggagg caacgccaaa cagctttgtg atcgagttat atacaagatc cgtaccgacc 1234681 gcgatggaag gattaattcc aagcacaatt aaaaggggag ttaataaggc cgctccaccc 1234741 actcccgtca atccgactaa ggctccgaca aacaaaccca tcaatatgat gcttacactc 1234801 atgataaagg cctcctgaaa acccgactag aattcacccg aatcttattc gcgttggtca 1234861 agtattaatt gtaagtgctc catcggctgc tgaaaaaccc gagctctatc cgctccctga 1234921 tggtatcatt caattgacaa caccttatac atcaggagaa cacgtctttc aggtgcaacg 1234981 agcacttgcg gctctgtatt tttaccctga taaaggcgct gttaacaacg gaattgacgg 1235041 cgtttacgga ccgaaaacag ctgacgcagt tgcccgtttt cagtctgtta acggtctaac 1235101 tgctgacggt atctacgggc ctgcgacgaa agagaagatc gcagcgcaat taagctgatc 1235161 aaagaccata aaaatcccgg agccgctccg ggatttattt tttcttcttc aactttttta 1235221 taattccagc actgcgctcc ctcacccgaa gcgagtaccc ggaaagccca aaccttccgt 1235281 aatcaacaaa cttcacacgc ctcaccaatt ttttcactgt atcacctgac attatcctct 1235341 gtttgtattt attatatgtc accctttaag aaaaggaata aggacaagag ctgttttccc 1235401 ttgtcctttt agtgtgatca tgcttttttt cgtttatact cgtcaatcag ccgttcgttt 1235461 tctttgaaga ttcttgctgt atgcggactg acttgatagc ttgcgacact ggtggttgaa 1235521 cgttttttca ggattttaaa cggcttcgcc gctctgggct cgcatctgtt ttgaaacgca 1235581 cgttccatta tccttcacct tcctcctcaa ttggcagcac caaatcatat atgctcgtta 1235641 atgacgtaaa tagcaaataa tcaaattccg tgacaatgct gtcagacgtc agcttgatga 1235701 catagttctg tgtctcgatg gtaaaaggga tgagaaccac ttttccgtat tggtcgtaat 1235761 aaacatcctt tcgatcgagc cgtgtttgta catctgccgg atcatccata tgctcggtta 1235821 accggtcttt atcagcctgt gtcgaatagt ggcaaagaga agccgttaag ttcattttat 1235881 cagcataggt tttcagcagc ttatcaatac cttcagcata agcatctata cttccataat 1235941 aaacatggat cggttcgttt ttcaataggt attggtatgt tttcagccga ttgagataca 1236001 tgtggagcat ttcgttgttt tcttcaagaa tttctcttgt gtctgtttca agctcgctgc 1236061 cggccagttt tttgacatat gcacttaaga agataaaagc atcaatcaaa gcaaaactga 1236121 ctgcgacaat gagataccgt tcccagtggg taaataggga agtgggctca tatgtccagt 1236181 ataccatagc gcccagaaca aacagcaaat accaagtttt ccgaatggcg gacatttttt 1236241 ctttgacctt cgcttcgaaa cgccacgtgg catacacgta taaccccagt ccggccacga 1236301 tgcaccagac catgatctga aagaataaaa ccatattcga atccctcaca tctgaaatag 1236361 gttctgctta ttgtattcga gagatccgga tggttttcct gttccatcaa aaaaaccgct 1236421 cctttgacag aagcggtgtg acattaaaat atcatattta aaataaagta ggcgatggca 1236481 ccaagtgtcg ctgaaatcgg aagcgtgatg acccatgtaa tgagcattcg cttggccgta 1236541 ccccagttta cgccttttac gcggtgggac gcaccgacgc caagaattga tgaagaaatg 1236601 acgtgggttg tactgaccgg caaatgaata aacgtggcgc cgaaaataat ggctgctccg 1236661 gttaagtcag cggaaacacc gtttaccgga cggattttca tgatctttcc gccaacggtt 1236721 ttgatgattt tccagccgcc gattgatgtt ccgagaccca tggctgtcgc gcaggcgaat 1236781 tgcacccagg taggaatatc attagcagaa gtatgtaaat tcgctgtgat gagagccatt 1236841 gtgataattc ccattgcttt ttgcgcatcg tttgttccgt gtgtatacga ttgcagggca 1236901 gctgttacaa tctgcactct gcggaattgc ttattcgttt tcgccaagtt gctgtctttg 1236961 aaaatcagct taacgatgct ataaagaata aaaccaagga caaaggcaat aattggtgat 1237021 agaatcagtg cttcaatgat tttaatgaag cccttatagt ttaacgctgc aaatccggct 1237081 gccgcaatgg ctgcaccggc aatagcgccg atgatggcat gggatgagct gcttgggata 1237141 ccgtagtacc atgtgataag gttccaggca attgcagcga gtagcgcagc caaaatgaca 1237201 acagagccat tttccagcgt ataaggatct acgatgtctt tcgtaatggt tttggcaaca 1237261 cctgtaaacg tcattgctcc gacaaagttc atcacagcag ccaatataat ggcatggcgc 1237321 ggttttaacg cttttgttga taccgaagtc gcaattgcgt ttgccgtatc atgaaacccg 1237381 ttgatgaaat caaacgccag agcacaaatg actattagta tcgttaatat taatagaata 1237441 tccattttta cccctcgtta cgcgtttttc ataatgatgg tttcaagatt attggcaaca 1237501 ctttgacaag agtcggcgat ttcttcaagc gtttcgtata tttcacgata ttgaatgact 1237561 ttgattggat ctgtttcatt tccgaaaaga ttctttaatg attttctgtg caagttgtca 1237621 caactgtgct catactcttt aattttgatt gcgtgaggct gaatatcctt taagcgattt 1237681 tctgccagca gctcgatcgt aatcaaaatc tctttcgcac attctctgat atatccgctg 1237741 aatttatcaa tatgctcgtc tgatgaagta attgagaaaa tctccatcat ggcagagaaa 1237801 tgttcgattc cgtcaagcac atcatccaag ctgtttgtca gctgaaggat atcttcgcgc 1237861 tcaataggag tgatgaacgc tttgttaagc tctttaatca tgacatgaac atgattgtca 1237921 ccttttgttt catattcctt taacgtatct gcaaattctt taagagtcgt ttggttagtg 1237981 accttaaaat tcacaaaata ttctgcagtt tcgtctatgt tctttgcaat ttctgttaaa 1238041 aggagtgaga acttatcttt ttttcttctt atcattaaaa accctccata gtttgaatga 1238101 acaatgcaca catcaaatta ttatatagcc ttttgtcgaa aaaaaacagg taaagtcgaa 1238161 aaaaacgtat cttgactttt ttgataaatc gtgtctcctt attttgacct acttcgcttt 1238221 aaaaaaacga cccaagtttg caaaaacttt ctgcttaacg taaaaagtat atcaaaagtt 1238281 gtgtttttcc tgtcaacttt tatcttctgt ttcaccaaaa aacggttccc taaacaaggg 1238341 aaccgtttta tcagcttgct tttcgttttt tcatcccgta ataaacaggc agtccggcaa 1238401 ggccgatgag gatggataat ccgcagctca ttgtatctgt aatgagtgtg ctgcctaaca 1238461 caaagaagga gcccgcgatt gccagaattg gcataaatgg ataaagcgga acactgtagg 1238521 cgcgcttttc tccctttgct cgcttgcgga gaataaacac tgcaaaaaag gccatcacat 1238581 aaaaaatgta gatcatgaaa atggagattt ctgagagctt atcagggttg ctgatcagca 1238641 tcataatcaa agccaaagca atttgaaaag aaatcgcaat ccatggtgtg cggaacgacg 1238701 ggtgtacatg tgacagtttt tcagcaaatg gaagctgttt gcgttccgcc attgcaaatg 1238761 aaacacgcgg gaaagaaagc acctttccat ttaagcaccc aaagatgctg acgataatcc 1238821 ctacactgat cagctttccg ccaattgaac cgaacagcat ggttgcagcg gtgcttgtcg 1238881 cattttcacc aagcgtgaca atttcgttcg ctgacaggat gtgaagcaat gcaaaattaa 1238941 tgaaaatata gatcgccgtt acaattaata atccgcccgt catagcgcgt ggcagcagct 1239001 tttcgggatt tttcatttct ccgccgagag cggcaaggag aatccatccg tcataagcaa 1239061 acaacgtagc taaaatagcc gccccgaagt tcatatcaga aatgctttcg tttactgctg 1239121 tgaagatgtg ctgatcgcct ttccaaaggc caaagacgat gatgcaggca atcggaatca 1239181 gttttccgat cgttgtcagc gtttggacaa aaccgccgta ttttgtaccg ataatattaa 1239241 tgacgcataa aaagagaact gctataattc caatgacttt tgatagtcca gatccccagc 1239301 cgaaaagatt cgccattaaa gatccaaaat ataaacccag cgcgccaata atcgccgggc 1239361 cgtaaatgat aatctgcacc cagccgcaca aaaatcccca aaactcgccg tacacttctt 1239421 caaggtacgt ataaagcccg ccggtttttg gaatctgcgt tccgatttcc gcgattgtca 1239481 aaccgcccgc cagtgttaaa ataccgccta acagccaggc gaaaagcgcc atttttgaat 1239541 cacctgaata agcaagcaca gcgccgggct tcataaaaac accagaaccg ataatggttc 1239601 cgatgacaag agtaagggca aacaagaggc ctatctcttt tttcaaaccg ttgtcttcag 1239661 tatgcatgtc cttaacctcc tatgatgttg aagcttcatg ttgaagaatc tattttttca 1239721 tattgtaaac cctattttag aaaagtgaaa taaaataaat tttctgattt tcgaaatttg 1239781 ctttgtgtac agcagataaa actgtagaaa tacctgtttt aatggtctat aaacgaataa 1239841 aattcataat ttttatttac aaagttcgtg ttttatgtat taggatttta gccggtacag 1239901 aggggagatg agaattcaga aaatgaacga accttcggtg aagctgatat gttgactttc 1239961 tcatgcgaat aaaatacttt gttattagaa caataaatat acaattatga tatgatatct 1240021 cgaaatcgag ataaaataac ctggagggac agcatatgaa agttaacggc attcaccacg 1240081 tatcggcatt aacggccgac gcacaaaaaa acttggattt ctataagaaa gtattaggat 1240141 taaagctcgt caaaaaatcc gtcaatcagg atgaaccgac aatgtaccat ctgttctacg 1240201 gagatgaagt ggcaaacccg ggaactgagc tgacgttttt cgagattccc cgcattgcac 1240261 cgtttcatgc gggaacaaac agtatttctt ctattggatt gcgcgttcca ggcacagaag 1240321 ccctgcatta ctggaaagaa cgttttgaag agcagcaagt aacgcacagc ggcatctcca 1240381 aaagagccgg acgtgacata ttggcatttc aagatcatga ggggcagcga cttgtgctga 1240441 ctgctgatga ggaaggaaaa ggatatggcc tgcctgttaa acagagcggc attccggaag 1240501 aattttcgtt tcgcgggtta gggccggttg aactgactgt gccatatgct gaaccaactt 1240561 tacacgtatt gacgaatatt cttggattta cagaaatcag ccgtgaacca gtcgaagggc 1240621 aaggaaccgc cgttattctg gaatcaggag aaggcggtgc tgcaacggaa atccatttaa 1240681 tagaaagaaa cgatcttccg cgagagcgtc aaggcaaagg gagtgttcac cacgtcgcat 1240741 ttcgggtaag agatgaagaa gaacttgccg ggtggcaccg gatcatcagc cgcgaaggct 1240801 ttagcaattc aggcatagtt gagcgctact atttcaaggc gctgtatttc agagaaccga 1240861 acggcatttt gttcgagtta tcaacagacg gaccgggctt tatggtagat gaaaatcttg 1240921 atgagcttgg ccaaacgatt gctcttccgc catatctaga gcatcgaaga gcagaaattg 1240981 aagcaaaatt gaaaccgatc caataaattg tgattctttt gccttccggc gccgccggag 1241041 ggcttttttt attaccataa ttaattttga cctaaacagc atgccttatt agggaggaaa 1241101 tatcagatgc tgattgggag aaatggctta aaaccctttg caaatatggg tgattggtat 1241161 ggaatggcct cggcaaaaat attgtctttg tttattaata gtttattcat atttgcttgt 1241221 tacactattt caaagttaga caaaaaggag tgaaaaataa gtggaaaaga aaaaacgcga 1241281 gctggatatc gtcctcctcc tcattttgct cgcatctgca ttcttaaata tctataacat 1241341 ttggaaggac gacacggtga atccttatta caccgcggca gttacaagta tgatgcaaag 1241401 ctttcataat ttcttttatg cttcgttcga tgctgccggc tttataacag tagataaacc 1241461 gcctgttaca taccaaatcc aaacgatcag cgcactgata ttcggtatgc acggctggag 1241521 cgtcatcctg cctcaggcac ttgctggtgt aggttctgtc cttcttatgt acttgctgat 1241581 aaagccgaca tttggaaaaa cggcggcgcg tattgcctca tttgttatgg catgtacgcc 1241641 gatagctgta gctgtagcac gtacaaacaa tgttgatgca ttactggtat ttttcttatt 1241701 gcttgctaca tggcttctct ttaaagcgat cagaaaagga aagctgatct ggctgttagc 1241761 agcatttttc gttgttggag taggttttaa tacaaaaatg ctgcaggctt acatgatttt 1241821 accggctttc ttattgttct atctgattgc ggcaaacgcc acaatcaaga aaaaaatcgt 1241881 ttcattggta agtgcgttag ccgtattagc agccgtttcg ttatcgtggc cgctcattgt 1241941 tgacaatatc cctgcaagca agcggcctta tatcggaagc agccaaacca actctgtttt 1242001 ggaattggct ttcggctata acggaatcca gcggctgaca ggccaaaatt caggcggcgg 1242061 ccagggtgcg ccaaacaaag acgcttcaaa agaaatgtct tcttctgata acactcaagc 1242121 accgcctaat cagtcatcaa gcaacagctc atcaagcgat ggtaaatcct caaatggcaa 1242181 tatggcggcg cctccatcca atggccaaat gccaagcggc ggtcaaggag gccctccaag 1242241 cggcggagat ggcggccaag gcggacccgg cggagacgga gggaaaggcg gtacaggaac 1242301 cggttcgaaa atgcaatcag gttcagggat gtttggaacg ggaacacctg gtccactgcg 1242361 gcttttccaa caagagttat ctgatcaaat cagctggctt ctgccatttg cgatatttgg 1242421 aatcgcaggc ttactgatcg ctggcgcaag agaaagaaga agattatctg tagagcagaa 1242481 ggaaacggtg ttctgggttg cgtggcttgt accgattgcc ggattcttca gtgtcgcaga 1242541 atttttccat cattattatc tcatcatgct ggcaccgccg attgcggctc ttgtcggtgc 1242601 ggggtgggtc gctcttgttc atctgtaccg caatcagaca ggctggaaag catggctttt 1242661 gccgggagca attattgcga caactggatt tgaattgttt attctcagaa actacaacga 1242721 tcaaatcggt gttggatgga gtatcggggt aggtgttatc ggcgtgttgt cagcgattgc 1242781 tttgctgctg tttaaacagc gccaaaaacc gttcagttat tatgtttcac ttgcagctct 1242841 cctcgcattg ctggtgatgc cgatgtattg ggcaagtaca ccgcttctgt acggaggcaa 1242901 cagctcactg cctgaaacag gccctcaact cgcatcaatg agcggaaaag gcatgggaat 1242961 gtctgatgcg actgtaaatg aaaaactgat caaatatcta gaggagaata actccggagc 1243021 tgaataccta ttcgccacaa ccgattcgaa cacagcggca ccatatatca ttaaaacgaa 1243081 aaaagctgtc atggctattg gtggatacag cggttctgac ccggcaatca cactgactca 1243141 attcaaaaaa cttgtaaaag aaggaaaagt gaaatacttc ttggcttctg gaatgggaag 1243201 aggcggaaac aatgacattg ttgaatgggt tgagaaaaat ggaaaagaag tagcatcaga 1243261 aaaatggcaa tcaagttctg atcaaaaaac agaaaatact gattcagctg atacatcaag 1243321 cagcaaggct tcaggtgaaa acggcaaaat gggcggacct ggcggaatga atcagtcagc 1243381 aacattatac gaactacatg ctgatgaata ggaggcaaaa acatgagcag acatattcaa 1243441 tattcaattg ttgtacctgt gtataatgaa gagcttgtca ttcatgaaac ctatcagcgc 1243501 ttaaaagagg tcatggatca aacgaaggaa aactacgagc tgctttttgt caacgatggc 1243561 agcaaagacc gcagtattga gattttaaga gagcacagcc tgatcgatcc gagagtgaaa 1243621 attattgatt tttcaaggaa ttttggacat cagatcgcca ttacggcagg tatggattat 1243681 gcacagggga atgcaatcgt cgtcattgac gccgatttgc aggaccctcc tgaactgatt 1243741 ttagaaatga ttgaaaagtg gaaggaaggc tatgaagtcg tgtacgccgt acggactaaa 1243801 cgaaaagggg aaaccttttt caaaaaacaa accgcggcta tgttttaccg gcttctcagc 1243861 ggtatgacag atattgatat cccgattgat acgggggatt ttcgcctcat ggacagaaaa 1243921 gtctgtgatg aaatgaagag attaaaagaa aaaaatccat ttgtaagagg gctagtcagc 1243981 tgggtgggtt tcaaacagac agcggtcgag tatgtacgtg atgaaaggct cgccggagaa 1244041 acaaagtacc cgctcaagaa aatgctgaag ctgtcaatgg acggcatcac gacattttca 1244101 cataaaccgc tgaagctggc aagctatgcg gggattttaa tgtcaggtac tggatttctg 1244161 tatatgttta tcgtgctgta tctgaagcta ttcacagaca gcacgattac cggctggtca 1244221 tcacttattg tgatccagct cctgttcagc ggcattgtcc ttctgatttt gggcgtgatt 1244281 ggcgaatata tcggcagaat ctacgatgaa gccaaagaca ggccgcttta catcgtccaa 1244341 aaatcgtatg gaattgaaaa taaaagactc tatagagacc agcatatgtc ataacctcaa 1244401 accccctgtc cgtaatggac agggggtttt tatgctctga gcacgatcta aagcaaaaga 1244461 tgctgataga tatatggaaa ttgggtaaag aagagattgt gagcttgtac tgcggttcag 1244521 tcatgctgaa ataaaaacag caaaacttaa agatttcgtc ctcggctttg ctgcatgtca 1244581 gctgttatat tggggggctt ttaagaaacg catgattaga gccgtaccag ttatgtttaa 1244641 tagaatactc gtacccaata caattcccca cgtcaacgtc gattcagaga gaagaaagct 1244701 cagcaaaaga aaagccaatc ctgcgcagat catacccagt cccacggttt tcatgttcat 1244761 gcctcctagc aaacgatgtt tctagcatct gatgtgaatg atgtcaatct gtatgatata 1244821 cggatatctc gtcagaaagt ttcatagaac aattaggtct tttatctaat aaaaagcctc 1244881 agaccgcttt tacggcctga ggcattatgt cttacgaagt tttctcttct ttttgatcca 1244941 gtttaatttt tttcgtcatt tctttgccgt ttcggagaat tttcacttca acggtatcac 1245001 cgatctttgc gtctttatat aagatattgc gcaattcact gcctgtatca atttctttac 1245061 cttttaggcc gatgataata tcctccgctt ttaatccggc cttttcagca ggagagcctg 1245121 aagcgacctc acggatgtaa acgcctttat tcagctggct gccgaacagg ccgagtgtgc 1245181 cttcttggta attttgcggc acttgctcta gatcaagcat gctgacaccg atatatggac 1245241 gttcaatttg tcctttagac agcaattctt cagcaatcgg ttttacgtca ttgcttggaa 1245301 tggcgaatcc gataccctca acatcatcct cactgatttt catactgtta atgccgacaa 1245361 ttttgccgtc tgtatttaac aaaggaccgc cgctgttacc tggattaatt gctgcgtctg 1245421 tctgaatgac gttaatgctc gtttcgccgg ctgatgtaga cattgaaacc gttctgtcca 1245481 cgccgcttac aattccttgt gttactgtgc gggacaggtc ttttccaagc ggatccccaa 1245541 tcgcaataac ggtctcgcct gttctaagat cagatgaatc accgaagttt gccacttttg 1245601 tgacgtggtc atcactgatt tggaggacgg ctaaatcagt taacgagtca ctgcctacca 1245661 gctttgcagt aacctcagtg ccgtcatata aagatacctt cagtgatgat gccccttcta 1245721 cgacgtggtt atttgtaatg atataagcct tgccattctc ttttttgaaa atgacacctg 1245781 accctgaacc gctttctgta tcttcgctgg aatcagaaga actagagccg aacaaagagc 1245841 tgtttgattg tgcctgaaga tttgtaatac cgacaatcgc tggtgaaagg tcttctacca 1245901 tatctgagat tttagaagag tcctcgctct tgaatgcaga tgagctgctt gagctttttt 1245961 tagattcaga ggaggtgctt gttgctgtaa cagattgcgt ttgctgctgg ctggatgatt 1246021 gttttgcagt gtcctgagaa tcatggtcac caagcggtgt aaacgtgtaa atgccaagag 1246081 caagactgcc gccgatcact ccgccaagca acggtctgaa ccatccgaat cctcgttttt 1246141 tcttctcctg atcatgaatg acattgcggg ccgagtagga ggcgctctga tcgttctctt 1246201 tcgttaaaaa gacctcattc tcattacctt tcgttctgtt ttcatcacga tagttatcca 1246261 tcatgttcac tccgtttctc tattttcaca tgtctattta tattgatagg tttatgactt 1246321 gagtttatca taaacaaaaa ctgtgggata aaaatgaaaa gattatggga aattgtgaaa 1246381 aagtgcggaa aacggtacac ttcatattgt atatgaaagg actgagtcga tggaacagat 1246441 tggattgatt ggatatggca gcatggcgga tatgatcgct agacagctgt tgaaacatga 1246501 acaaataaaa gagaatgagc tatttattga gacgagaacg aagggggagc ggctgcgggc 1246561 actcatgtca gattatccaa acgtatcggc tgatccgttg gagaattggg caaatacgtg 1246621 ccaattgatt ttgatatgcg tcccgccact ccatgtcatc gaaacaatgc gccgtctgta 1246681 cccgtatgtg aacagaaata ctcacatcgt atccatagct gccggtgtgc cgctgcgtct 1246741 tttggaggca gaaacagaag ccggtatctc acgtgttatt cctgccatta cgtccgaagc 1246801 agaagccggc atctcacttg tcgttcacag tgaagcactg gctgcagaga aaaaagaacg 1246861 tctgaatgaa ttgttatcgg ttttcagccg tgtacgggaa atcaaagaat cgaatttaga 1246921 tgtggccagc aatttaacga gctcggcacc gggattcata gctgcaatct ttgaagaact 1246981 ggcactgtct gccgtcagaa acagcagcct gtccaaagaa gaagcctttg attttctgat 1247041 tcattcgcta tacggaactg gcaagatgct gatcgaaaaa aatatgtctt tcgaggagac 1247101 gctggaacgt gttgcaacca aaggcggaat aacgggagag ggagctgagg tgatacacgc 1247161 ctctgtgccg gacgtttttg atgaggtatt tgaaagaacc ctgagaaaat atgaactgct 1247221 tacagaacag gttggtaaac aaacatgaat ccttgaaaga ggattctttt tttatcactg 1247281 aatgattgag atttttccca gttatattgc atttttcctc tttttttaat ataatttgtt 1247341 agaatattca taatttagta aaaaaggagg agcgttatga aattgtacat gtcagtagat 1247401 atggaaggta tttcgggtct tccggacgat acctttgtgg attccggcaa gcggaattat 1247461 gaacgcggac ggcttatcat gactgaagaa gcaaactact gtattgctga agcgtttaac 1247521 agcgggtgta ccgaggtgct ggtcaatgac agtcattcga agatgaataa tctgatggtt 1247581 gaaaagcttc accctgaagc agacttgatt tctggtgacg tcaaaccatt ttcaatggtg 1247641 gagggactgg atgatacgtt tagaggcgct ttgtttctcg gttatcatgc gagagcctcg 1247701 actcctggtg tcatgtcaca cagcatgatt ttcggcgtcc gtcattttta cataaacgat 1247761 cggcctgtcg gtgagcttgg attaaatgca tacgttgccg gttattatga tgtcccggta 1247821 ttaatggtag ccggggatga ccgggcggcg aaggaagcag aagagcttat cccgaacgtg 1247881 acgacagccg cagtcaaaca aaccatttca agatccgcag tgaagtgctt gtcgcctgcg 1247941 aaagccggac ggctgttgac agaaaaaacc gcatttgccc tgcaaaacaa ggacaaagtc 1248001 aagccgctca caccgcctga caggccagtt ctgagcattg aattcgccaa ttatggccaa 1248061 gcagaatggg cgaatctgat gccgggaacg gaaatcaaga cgggaactac aaccgttcaa 1248121 tttcaggcga aggacatgct tgaagcctat caggcgatgc ttgtcatgac tgagcttgcg 1248181 atgcggacat cattctgcta aaggggtgtt ttaggctttg gcgcgataca tgataaagcg 1248241 tttttgggca atggcagcta cgattttggt gattaccacc ctgacttttg ttctcatgaa 1248301 ggtcattccc ggatctcctt ttaacgagga gagaggcaca aatgaagccg ttcaaaaaaa 1248361 tctcgaagcc tactatcact tagacgatcc tctcattttc caatacattt tctacttaaa 1248421 atccatcatt acattcgatt tcggaccttc aattaaaaaa ccgtcggaca gcgtaaatga 1248481 tatgctggaa cgcggatttc ccgtttcctt tgagcttggg atgacagcga ttgtcattgc 1248541 tgtgatttct gggctggtgc tgggcgtaat cgctgcactc cgccgcaatg gctttttgga 1248601 ctacgccgcg atgagtcttg cagtactcgg catctccatc ccgaatttta ttctggcaac 1248661 attgctcatt cagcaatttg ctgtcaatct caaactattt cccgctgcga catggacgag 1248721 cccgattcat atggtgcttc cgaccgcagc gcttgctgta gggccaatgg cgatcattgc 1248781 caggctgaca cggtcgagca tggtcgaagt tctgacacag gattatatcc gcacagcaaa 1248841 agcaaaaggg ctttctccgt tcaaaattat cgtaaaacac gcactcagaa atgcactcat 1248901 gcccgtcatt accgtcctgg gcacactcgt cgccagcatc ttaacaggaa gctttgtcat 1248961 tgaaaaaatc tttgccattc cgggaatggg aaaatatttt gttgaaagca ttaatcagcg 1249021 ggactacccc gtgattatgg gaacgaccgt tttttacagc gtcattctga ttatcatgct 1249081 gtttttggtc gatttggcct acggtctctt agacccgcgc attaaactgc ataagaaagg 1249141 gtgaagcgtg tgaatctccc tgtacaaacg gatgaacgcc agccagaaca gcacaatcag 1249201 gtgcctgatg agtggtttgt cttgaatcag gaaaaaaatc gggaagccga ttcggtcaag 1249261 cggccgagtt tgtcatacac gcaggatgcc tggaggaggc tgaaaaaaaa taaattagcg 1249321 atggccggac tctttattct tttatttctt tttgtcatgg cagttatcgg gcccttttta 1249381 tcgccccata gtgtcgtacg ccaatcgctg acagaacaaa atcttccgcc ctcagccgat 1249441 cattggttcg gcaccgatga actcggccgg gatgtgttta cccgaacatg gtatggcgcg 1249501 agaatctcgt tgtttgtcgg cgtgatggca gcactgattg attttttgat cggtgtcatt 1249561 tacggaggcg ttgccggcta taaaggcggc aggattgaca gcattatgat gcggattatc 1249621 gaagtgctgt acggactgcc gtatctgctt gttgtcattt tgctgatggt gctcatggga 1249681 ccgggactgg gcacgattat tgtggcgctg actgtgaccg ggtgggtcgg catggcgaga 1249741 attgtaagag gccaggtgct tcagattaaa aattatgaat atgtactcgc ctcgaaaacc 1249801 tttggcgcga aaacctttcg catcatccgg aagaatttgc tgccgaatac tatgggagcg 1249861 atcatcgtac aaatgacatt aaccgtacct gccgccatat tcgcagaatc atttttaagc 1249921 tttctcggcc tgggcataca ggctccgttt gcaagttggg gcgtgatggc gaatgacggc 1249981 ctgcctacga ttttatctgg gcattggtgg cgcctgtttt ttccggcctt tttcatatct 1250041 ctgacgatgt acgcgtttaa tgtgctgggg gacggattgc aggatgcgct tgaccctaag 1250101 ctgaggaggt agctgtatgg aaaaagttct gtcagtccaa aatctgcacg tgtcttttac 1250161 gacttacggc gggacggttc aggcggtcag aggggtgagc tttgatttgt ataaaggaga 1250221 aacctttgcg atcgtcggcg aatccggctg cggcaaaagc gttacctccc aaagcatcat 1250281 gggcctgctt ccgccttatt cggcgaaggt gacagacggc aggattctat ttaaaaacaa 1250341 agacctttgc cgtctctctg acaaagaaat gagaggtata aggggagccg acatttctat 1250401 gatttttcaa gacccgatga cggcgttaaa ccctacgctg actgtcggcg accagctggg 1250461 ggaagcgcta ttgcgccaca aaaaaatgag caaaaaagcg gcacggaaag aggtgctttc 1250521 catgctgtca ttggttggta ttccagatcc cggagagcgc ctaaagcaat atccccacca 1250581 attcagcggc ggtatgagac agcggattgt cattgcgatg gcgctgattt gcgagcctga 1250641 tatcttaatt gcggatgaac cgaccaccgc cctggatgta accattcagg cacagatttt 1250701 agagctgttt aaagagattc agagaaaaac ggatgtgtct gtcattctga ttacgcacga 1250761 tttaggggtt gttgcccagg tagctgacag agtcgcagtc atgtatgccg ggaaaatggc 1250821 ggaaatcggc acaagaaaag atatttttta tcagccgcag cacccatata caaaaggcct 1250881 gctgggctct gtcccgcggc tggatttaaa tggcgctgag ctgaccccga ttgacggaac 1250941 gccgccggat ttattttcgc ctccgccggg ctgcccgttt gccgcccgct gtccgaacag 1251001 gatggttgtg tgtgacaggg tgtacccggg ccagacgatc agatctgact cgcacaccgt 1251061 caactgctgg ctgcaggatc aacgagcaga gcatgcggtg ctgtcaggag atgcgaagga 1251121 ttgaacatga aaagggggaa gaggatgaaa cgagtgaaaa agctatgggg catgggtctt 1251181 gcattaggac tttcgtttgc gctgatgggg tgcacagcaa atgaacaggc cggaaaagaa 1251241 ggcagtcatg ataaggcaaa aaccagcgga gaaaaggtgc tgtatgtaaa taatgaaaat 1251301 gaaccgactt cattcgatcc gccgatcggc tttaataatg tgtcatggca gccgttaaat 1251361 aacatcatgg aggggctgac gcgtcttggc aaagatcatg agcccgagcc ggcaatggcg 1251421 gagaaatggt ctgtttcgaa agataataaa acttacacat ttacgattcg ggaaaatgcg 1251481 aaatggacaa acggagatcc tgtaacagcc ggagacttcg aatacgcgtg gaagcggatg 1251541 cttgatccga aaaaaggcgc ttcatcggca ttcctaggtt attttattga aggcggcgaa 1251601 gcatataaca gcgggaaagg gaaaaaagac gatgtgaagg tgacggcaaa ggatgatcga 1251661 acccttgaag ttacactgga agcaccgcaa aaatatttcc tgagcgttgt gtccaatccc 1251721 gcgtatttcc cggtaaatga aaaggtcgat aaagacaatc caaagtggtt tgctgagtcg 1251781 gatacatttg tcggaaacgg cccgtttaag ctgacggaat ggaagcatga tgacagcatc 1251841 acaatggaga aaagcgacac gtattgggat aaggatacag tgaagcttga taaggtgaaa 1251901 tgggcgatgg tcagtgacag aaatacagat taccagatgt ttcaatcagg ggaacttgat 1251961 accgcttatg tccctgctga gctgagtgat cagctgcttg atcaggataa cgtcaatatt 1252021 gttgaccagg cgggtctcta tttctatcga tttaatgtca acatggagcc gttccaaaat 1252081 gaaaacatca gaaaagcctt tgcgatggct gtggatcaag aggaaattgt aaagtacgtc 1252141 acgaaaaata atgaaaaacc ggcgcacgcc tttgtatcgc ctgggtttac gcagcctgac 1252201 ggcaaagatt tccgtgaagc aggcggagac ctgatcaagc ctaacgaaag caaagcgaag 1252261 cagctgctcg aaaagggcat gaaggaagaa aactataata agcttcctgc gatcacgctt 1252321 acttacagca caaagccgga gcataaaaag attgccgaag ctattcagca aaaattgaaa 1252381 aatagccttg gagtcgatgt gaagctggcc aatatggaat ggaacgtatt tttagaggat 1252441 caaaaagcgc tgaaattcca attctctcaa agctcatttt tgcctgatta tgcagaccct 1252501 atcagttttc tggaagcctt tcaaacggga aattcgatga accgcacagg ctgggccaat 1252561 aaagaatacg atcagctgat caaacaggcg aaaaacgaag ccgatgaaaa aacacggttc 1252621 tctcttatgc atcaagctga agagctgctc atcaatgaag cgccgatcat tccggtttat 1252681 ttttataatc aggttcacct gcaaaatgaa caagtaaaag gaattgtccg tcaccctgtc 1252741 ggctatatcg atttaaaatg ggcagataaa aactgatgga ggcgattgag gaaatactgc 1252801 ttctttatgc gaaggagcgg tattttttct ctttcttgca cgtatacgta gggtgcagag 1252861 caaatgaaag gagtgttttc gttgaattac aagccgaaag cgttgaacaa gggtgataca 1252921 gtcggagtga tcgcgcccgc aagtccgccg gatccaaaaa agcttgacac cgcgctttta 1252981 tttttagaag agctcggtct tcaggtgaag ttgggcaagg cgctgaaaaa ccagcacggc 1253041 tatttagcgg gacaggatga tgagcggctg gcggatctcc atgagatgtt cagagacgat 1253101 gaggtaaaag cagtgttgtg cgcatgcggg ggttttggga caggacgtat cgccgcgggc 1253161 attgatttca gcttgatccg caaacaccct aaaatctttt ggggatacag cgatattacg 1253221 tttttacata ctgccattca tcaaaacaca ggtcttgtca ctttccatgg cccgatgctc 1253281 agcacggata ttggccttga cgacgttcac ccgctgacaa aagcgtcata taagcagctc 1253341 ttccaggaga cggaattcac ctatacagaa gagctttctc cgctgaccga gcttgttcct 1253401 ggaaaagcgg aaggcgagct tgtcggggga aatctgtctt tgctgacgtc tacactgggc 1253461 acgccatttg aaattgatac gagaggaaag cttctgttta ttgaagatat tgacgaggag 1253521 ccttatcaaa tcgaccggat gctgaatcag ctgaaaatgg gggggaagct gacggacgcg 1253581 gcgggaattc tagtttgtga ttttcacaat tgtgtcccgg tgaagcgaga gaagtctctc 1253641 tcgcttgagc aggtgctgga agactatatt atttctgcgg gcaggcctgc tctgagagga 1253701 tttaaaatcg gccactgctc gccaagtatt gccgttccga tcggtgcgaa agctgctatg 1253761 aatacagcag aaaaaacagc cgtaatagag gcgggcgttt cagaaggggc gctgaagaca 1253821 tgaaaatcat tcgaatcgaa acaagccgaa tcgctgtccc gctgacaaag ccgtttaaaa 1253881 ccgcacttcg cactgtgtat acggctgaat cagtcatagt aaggattact tatgacagcg 1253941 gtgcagtcgg atggggagaa gcacccccga cgttagtgat tacaggagac agcatggata 1254001 gcattgaaag tgccatccac catgtgttga agccggcatt gcttggaaaa agcctggcgg 1254061 gctatgaggc cattctgcac gacatccagc atcttcttac aggaaatatg agcgcgaagg 1254121 ctgctgtaga aatggctcta tacgacggct gggcgcagat gtgcgggctg ccgctttatc 1254181 aaatgcttgg cggatatcga gatacgctgg aaacagatta tactgtcagt gtcaactcac 1254241 ctgaagagat ggcagctgat gccgagaatt atctcaaaca aggctttcaa acgctgaaaa 1254301 taaaggtcgg aaaagatgat attgcaacag atatcgcccg tatccaggaa atcagaaaac 1254361 gtgtcggatc agctgtgaaa ctgcgtttag acgctaatca ggggtggagg ccgaaggaag 1254421 cggtaactgc cattcggaaa atggaggatg cgggcctagg cattgagctt gtcgagcagc 1254481 ctgtccataa agatgatctc gctgggctta aaaaggtgac agatgcaaca gatacgccga 1254541 ttatggctga tgaaagtgtt tttacaccgc gccaggcgtt cgaagttctg caaacccgga 1254601 gcgcagactt gatcaatatt aaattgatga aagcgggcgg catcagcgga gcagagaaaa 1254661 ttaatgccat ggcggaggcc tgcggggtgg agtgtatggt cggcagcatg atcgaaacga 1254721 agctgggcat tacggccgcg gcgcattttg cggcaagcaa gagaaacatc acacgctttg 1254781 attttgacgc gccgctgatg ctgaaaacag atgtattcaa tggcggcata acatatagcg 1254841 gcagcacgat ttcgatgcct ggcaaaccgg gcctcggaat catcggggct gcgcttttga 1254901 aaggggaaaa agagcaatga tgcacactgt catatcagca gtggccaaca tctggacagc 1254961 gcctgattca cctcgtccgt ctgatcaatt catgcttcaa ccgactgtaa tgatcagaga 1255021 ctggctggag cgcatgacgt atgatgaacg gcttggatta tgtacagaca atgtaatcca 1255081 aactcaggtt ctctttggcg aaaaggtact tgtgacggcg gaacaggggg aatgggtttc 1255141 tgtgatcgtg cctagccagc catcccgaaa ggatccgcgc ggatacccgg gctggatgaa 1255201 aaagtaccag ctggaaaaaa caaagcccat ccatacacaa cacgatgtga tgatcagcaa 1255261 acctgctgcc tttttgtaca gaagcaatgg ggaaaaggag atcgaattaa gctttttgac 1255321 agttctgccc cttattgcaa aagaaaacgg atattttaag gtttcgaccg tttttgggga 1255381 aaggtttgtg aggcaaagtg atgcagtgcc tgtcagccaa cagaaaggga ctgctgaaga 1255441 catcattcaa acgggtgcgt tttttcttgg ccttccctac ctgtggggag ggatcagcgg 1255501 gtttgggttt gattgctccg gatttatgta cagtatattt aaggcgaatg gatacagcat 1255561 cccccgtgat gcgggagatc aggctaaggc agggaagggt gtcccgcttg atgatatgaa 1255621 agccggtgat ctgctgtttt ttgcttatga ggaaggaaaa ggagcgattc atcacgtcgg 1255681 tctgtatgta ggcggcggga aaatgcttca ttctccaaag acagggaagt caatcgaaat 1255741 cctcacatta acagagacaa tctatgaaaa agaattatgt gcggtgcgcc gctgtttttc 1255801 agaataagga gggagacaaa tgaggcgact gcctttgtta gaggtcagcc agctgaaaat 1255861 gcattttgac gcagggaaaa agcggacagt caaagctgtc gacggggtca cctttcagat 1255921 tcgtgaagga gaaacgttcg ggctagtcgg ggaatcaggg tgcgggaaat caaccttggg 1255981 gagagtgctg atgcgccttt atcagccgac agaaggaagc gtgacatacc gcggcacaaa 1256041 tcttcatgca ctaagtgaaa aagagcagtt tgccttcaac cgcaaactgc agatgatttt 1256101 tcaggaccct tatgcttcac ttaacccgcg catgaccgtt cgagaaatta ttttggagcc 1256161 gatggagatt cataatctct acaataccca taaagcacgg cttctcgtcg tggacgagct 1256221 gcttgaggca gttgggcttc accccgattt tggcagccgt tatccgcatg aattcagcgg 1256281 cgggcaaagg cagagaatcg ggattgcgag agcactgtcg ctgaatcctg aatttatcgt 1256341 ggcggacgaa ccgatttctg cacttgatgt ctctgttcaa gcgcaggtgg tcaacctgct 1256401 gaagcggctt caaaaagaga aagggcttac gtttttattc attgcccatg atctttcgat 1256461 ggtgaagcat atcagtgaca ggatcggtgt tatgtactta ggacacatga tggaaattac 1256521 agagagcggc accttgtatc gtgaaccgct ccatccctat acaaaggcgc ttttgtcctc 1256581 gattccgatt ccagatcctg aattggagga caagcgtgag cgtattctct tgaaagggga 1256641 gctgccgagc ccggtcaatc cgccaagcgg ctgcgtgttt cgtacccgct gtccggaggc 1256701 gatgcctgaa tgtggagaat ctcgtcccca gcttcaagaa atcgaacccg gccgttttgt 1256761 cgcttgccat ttgtatcgaa atgctgaaac gaaggaaaaa gtaagataaa taaaaagagt 1256821 ggctcctttt tactagagcc actccatttg tttatacttg atgtaaaaac tttacacaaa 1256881 ccgggtaagg gacagaaacc gttgatggga ggagtgtcaa tcggccggtt tctttgtctc 1256941 tttcaaacaa gacaaggttg cctgtttctt catttgaagc aacgaggaac ccttccgttg 1257001 ggtcaaatac aaagtcacga ggccagtttc cttctgtcga cactctttct acgaaagcca 1257061 gctctcctga atattgattc acttcaaata cggcgatact gtcatggccg cggtttgcga 1257121 cataaacaaa acgtccgtcc tgcgtgacat gtattgcgct tccctggctg ttatctgtaa 1257181 aatcatcagg gatggcagaa acgacttgga tttctctaaa ttcgccggct gtcgggttgt 1257241 attcaagcgc aatcacttca ttgcttaatt ctgtcatgac ataagcgtat ttttctttcg 1257301 gatgaaaagc gatatggcga ggtcctgcac cgggagcgaa ggaatggctt ccggattcag 1257361 tcaacacacc gtctttaagc ttataggtgt agagcttatc tatacctaaa tcaaccgcta 1257421 ccacataatt gtgttcaggt gtgaaccccg cgtagtgtgt atgcggtttt tcttgtcttt 1257481 cgtgcggccc ttttcctgtg tgagcggcct ctgaaacagg tgattgcaag ctgccgtctt 1257541 cctgaaccgg aaaaacgtgt accttcccgc tgtgataatt ggcagtcagt acgaattgat 1257601 tttgatcatc aacgcttacg tggcatggcg aagggccatc aattaactga tgattcagaa 1257661 atgtcaattc gccgctgttt ttatcgattt gataggcagc aactccgcct tggccgtctg 1257721 ctttttcgat ggaataaagg atggtgttgt ttttattcgt cgccacatat gtcgggttgc 1257781 ccagcttagc ggccagcttt ggctcgctga gtgctttttt ctcagtatca agctcaaatg 1257841 aataaattcc ttcgcttccg ccttttgtat atgttcccac atatcctatg tattttgtca 1257901 tgcgatttcc cccttaaaaa tgatgtcacc tctatattaa cgtatcttga taaaataagc 1257961 tgttcaaaac atgaaaaagg ggaagattct tcattcgcct cgaatcagcg gcattgtgca 1258021 gcacctgaag gagccgcctg atttaataat ttctgacagg tcaatttcga taatgtgata 1258081 gcctcttttc gatagctgtt gattgacatg gcggttgcca gggagactga tgatcgtttt 1258141 ttttccgatt gaaaggacgt tggtgccaag cgtaaattgt tcgtcctcgg gcacctcaat 1258201 aagatcataa cgttttgcca gcatatcggc tgcatctggc tcaatggcct gtgaataaat 1258261 taacgcttcg ctttcagata taatgttaaa tacgcagtcc aaatgcaaaa atttttcatg 1258321 aagcttcact ggaacgatcg tatattcagg aagtgcctct tctagctggc cgatagctga 1258381 aatgtcggtg cgctggctga ttccgacata gacaatgtca tcatcgataa tgacgtctcc 1258441 gccttcaata ctcgtatcaa gcatgcgggt gtaagagata ccttggctgt gaaaaaaatc 1258501 ttttataacg gcttcttctc cttggcgaat cggttcagtc atgcttgaca gaaaggcttt 1258561 ttctccgatg acaaatccta tgtccctagt aaaaacctgt tctgggagtc cgtcgcgaac 1258621 gggcaaaagg acgacctcaa cgttgtgtga cctaagtgcc tccactaagc ggctgtgctg 1258681 gtcgttagcg gtttttacat gaatattgtc atcttcaaaa tgtttttgtg tttcgtttat 1258741 aacatctttt atggtcatgt gctcaggttt gcataagatc actttttgaa gtgtgccgta 1258801 ttccgttcgg cataccgttt tgtgctgaga tttcgggatg gatacgtcca tttgtttttc 1258861 ctcctaaagt gtgaagaata catttattat tccctcatca tgaaaatcat taaaccattt 1258921 taaattttag acaaatggaa gagaatattg tttaatagga gaatataagt gcatttagct 1258981 aaaagatcag acatcaaagg ggagaaaggt atggaaacac cggaaacaag attttgtaaa 1259041 gagtcaaagg ttgtgaaaac cagcagggtg ttcccgcttg acacgaacaa ccataatacg 1259101 ctgtttggcg gaaaattaat gagctacata gacgacattg cctctatttc agcggcgcgc 1259161 cattgcagac gtgaaacggt aacagcttca atggattctg tagatttttt aaagccgatc 1259221 gggcaaaagg attctgtctg cctagagtca tatgtgacat gggtcggcac atcttccatg 1259281 gaagtatttg tgaaagttat taaggagcat ttgatgactg gcgaacggga actcgctgcc 1259341 acatcctttt tgacatttgt cgcattagat tcaaatggca agccggtgcc tgtaccgagg 1259401 gttgtaccgg aaacagaaga agaaatcatg ctgcataata cagctgtaca gcgtgctaat 1259461 gaacgtaaga accgcaagag acacagccag gcgcttgcaa atgcgctcgg aactgataag 1259521 ccttggtgaa cgttaaaccc aaaacataag ttgttttggg tttttttgta cttttcaatg 1259581 gtgattatta caatggttag tccgtttttg ctaggggatt ctataaaaaa gcaacaaatg 1259641 tcatgttaaa ttgataattt tgtgacaact ttattaaaga ttcattttag atatatcttt 1259701 tattcgtaag atcatgtatt ttaaagatat attttaaata catcttttcg aaaggattgt 1259761 ttataaaatg ttagataaca aaacaatcga aattattaaa agcactgtac ccgtattgca 1259821 acagcatgga gaaacaatca ctggccgttt ttacgatcgg atgtttcaag accatccaga 1259881 gcttttgaac atttttaatc aaacaaacca aaagaaaaaa acacagcgaa ctgcactggc 1259941 aaatgccgtt attgcagctg cggcaaacat tgaccaatta ggaaacatca ttccggttgt 1260001 caaacaaatc ggccacaagc accgcagtat cggaattaag cctgagcact acccaatcgt 1260061 cggtaaatat ttgctgattg cgattaaaga tgtattggga gacgctgcaa ctcctgacat 1260121 tatgcaggca tgggaaaaag cgtacggagt cattgctgac gcgttcatcg gaattgaaaa 1260181 agacatgtat gaacaggctg aagagcaagc cggcggctgg aaggagtata agccattcgt 1260241 tatcgcaaaa aaagagcggg aaagcaaaga aattacatcc ttctatttga aaccggaaga 1260301 cagcaagccg ttacctgaat tccaagcagg gcaatatatc agcatcaaag tgcggattcc 1260361 tgattctgaa tatacgcata tccgccagta cagcctgtct gatatgccgg gaaaagacta 1260421 ttatcgaatt tcagtgaaga aagatggtgt cgtgtcttcc tacttacacg atgggctgca 1260481 ggagggagat tcaatagaga tcagcgcacc ggcaggggac tttgttttag atcatgcatc 1260541 acaaaaagat ctcgttttga tcagtgccgg agttggcatt acaccaatga tcagcatgct 1260601 gaaaacatct gtttccaaac agcctgaacg gcaaattctg ttcattcatg cggcgaaaaa 1260661 cagtgaatat catgcattgc gccatgaagt agaagaagca gcaaaacatt ctgctgttaa 1260721 aacagcattt gtgtatcgcg agccgacaga ggaagaccgt gcaggtgatc tgcattttca 1260781 tgaaggacag attgatcagc aattcctcaa agaactgatt gccaacacag atgcggatta 1260841 ctatatttgc ggttcaccgt cgtttattac ggcaatgcat aagcttgtat cagagctcgg 1260901 atcagcgccg gagtctatcc attacgagct attcggcccg caattaagtt tggcgcagtc 1260961 cgtttgaaca catacatgaa actcttctcc tttcagagaa gagtttttta ttgagatata 1261021 agaaggcaga caagcgccgg tttctacatc cggacaatca cagacccgct gccatttgtg 1261081 catacacggt tttgctgttc ttgcattgtt ctcagcaatt cattgtttac ctcaatcgct 1261141 ctaattagtt gcttcattct tagctccaaa ccggccagcc tgtcgattgt ttgctgctgg 1261201 tagccctcgg gttggggagc caatggcaga tcaaagggcc aaagggtatt cgacttctga 1261261 tttttcatat tgcgtattgc gcctccaatc ggtgtcactt tctattatgt tatgttcagg 1261321 cgatatgcac gttcgcctag acactgatgc atagagggcc tgccacgggg cacaataggc 1261381 tcaatatgac cagcggatgg aggtaaagat cggtgttatg gatggtatgg gtatttttac 1261441 tgaagccagt tatcgtattt tcgattgcat atattttgtt tcggcttgcc ggtaaaaaag 1261501 ctgtgtcaca aatgaacaat tttgacctgc ttttgacctt cgcaatcgga accattatca 1261561 gtgagccgat ccttacatcc aagctgccga tgtcaattta ttatgcgggt gcttttttgg 1261621 tgctttatct tatcatgagc aagctctctt tatctaataa atggcgatgg ctcctagtcg 1261681 tgagcccgac tgtcctaatc cgaaacgggg atattgatga acgcggcctt cgtaaagaaa 1261741 ggctgactgt taatgagctg ctcggaaagc tgagggaaaa gggctatgcc gacccggctg 1261801 acattgatct tgctatcatt gaagaaacgg gagaagtaag cgtcatcccg aaagaggaag 1261861 cgagagcggt gcaggtgcgg gatttgaata tggaagctga acggaatttt atcccgattc 1261921 cgctcatact ggatggcgaa atccttgatc ataatttgaa atatctccaa aaaaaccgat 1261981 cctggctgtt tgagaagctt gaggaaaaag ggtacagccc caaactgctg tcttcgatta 1262041 tccttggcac gatgaatgca cgcggtgata tatcccttga tttaaatacc gctaatgaac 1262101 cgcagcatga tccttactta tataaaccgg gaaataacaa ttaagatggc tctctcttgt 1262161 aatgagagct tttttctttt ttaaagggaa tttttgtttg gtgtcaaatg tacctagtta 1262221 ggaggggaac tgaacatgaa ggacttatcc ataagaaacg acatggcgcc aacggtcagt 1262281 ttgctgtatt ccgcagtgga agaaaacagt ctccgtctgg cttccatcgt aagccatatg 1262341 acacacagtg aactttacta taaggggcgc tgccaaacaa aaaacagcac ggctcagctt 1262401 ttgcaccata tcacaaatgt tgatatcaga tgggtctggc gtatcaagga aaatcggatc 1262461 ccggaccata ttgaacaggc atacggcccg atgacagatg aaagcggacg gctgcctgaa 1262521 ccggtgaatc agccagactt agatgaactc ctgaaaagac atcagcatgt agtagagaag 1262581 ctgaaatcgg tatgcttcac tttaactgaa aatgctttga accagccgct ttccttcgaa 1262641 ggtgacaccg cgacgatacg atggggaatt tggcatatgg cagatcataa ccgctatcat 1262701 caggcacata ttgaagctct caaaaaagaa tggaagcagg atgtggcgaa gtatgaacgc 1262761 taaaacgaag cttgtgactg atcgaattcg tttgcgctgt atggaagatc gggatcaagc 1262821 cactttgttt gggctgcttt ttaatgatcc tgacgtcatg acatattatt ccggtttaaa 1262881 agataagagg caaacccgcg agtgggtcaa ttggaaccaa cgaaatgaaa aagggtacgg 1262941 cgttagtctg tggatcgccg aagataagcg gacaggggag tttttggggc aatgcggcat 1263001 cgttccccag cagatcgaaa atcaaaccgt aatggaaatt ggctatatgt ttgcccgccg 1263061 ccactggggg aacggctatg cgcaagaagc ggctcgggcc tgtctggact atggctttaa 1263121 cgagcggcag ttcggcaaaa tggcggcttt gattgatccg ggtaacaaag cgtccatacg 1263181 ggtagcggag aaaatcggca tgcattacag caaaacgatc agaaaatgga ataaaccgat 1263241 cgcggtatat gaaagaaaat cttacaattg aaagatagag ctgagtttag tatcatgata 1263301 tcatgtaaag ttttctaggg ttccgcatgt caattgacat ggactggtcc gagagaaaac 1263361 acatacgcgt aaatagaagc gcgtatgcac acggagggaa aaaagcccgg gagagtcaat 1263421 ctcatgtgag acgactgtcc ggggtttttt tgttttcgga gaatcttaat agatagaaag 1263481 gaatgactca aaatgaaatg gggattggtc gtgcttgccg ctgttttcga ggttgtttgg 1263541 gtgataggct taaagcacgc tgactcagcc ttaacatgga gcggcactgc catcggcatc 1263601 atattcagct tttaccttct aatgaaggcg actcacagtc tgcctgttgg taccgtgtat 1263661 gccgtcttta ccgggctcgg cacagcggga acagtactta gtgaaatcgt tctttttcat 1263721 gaaccggttg gatggccgaa gctattgtta attggcgtgc tcttaatcgg tgtaatcggg 1263781 ttgaagcttg tgacacagga tgagacagag gaaaaaggag gcgaggcata atgctgcact 1263841 ggatcagttt attgtgcgcg ggctgtttag aaatggccgg cgtggccctt atgaatcaat 1263901 atgcgaaaga aaaaagcgtg aaatgggtgc tgttgatcat tgttggtttt gccgcttcat 1263961 tttccttgct gtcgtacgca atggaaacca ctccgatggg aacggcttac gcggtctgga 1264021 caggaattgg caccgccggc ggggcgctta tcggcatcct cttttacaag gagcagaaag 1264081 acgccaaacg gatcttcttt atcgcgttga ttttatgctc agcagttggt ttaaaaattc 1264141 tgtcataaat tgatttttat caaatcttca gtataatgga taaatagttt agacttacaa 1264201 agataagagg gattattcat gaaatcatat atgactcagc ggttggacga ataccgtgac 1264261 ggaaatgagg ataaaggtcg gctcttggtc agctgccccg atcagccggg tatcgtctct 1264321 gcagtttccg cgtttttatt tgaacacggt gccaatatta tagaatcaaa tcaatatacg 1264381 acagaccctg aaggcggccg gttcttcctg agaatcgaat tcgactgcgc aggcattcgt 1264441 gaaaaaaaat catcacttca ggcagcgttt gcctctgttg cggaaaaatt cgacatgaca 1264501 tggagcttaa ctttggcgag cgaactgaag cgtgtcgcca ttttcgtttc aaaggagctc 1264561 cactgcctgc atgagctgat ttgggaatgg caaaccggca acctgatggc ggagatcgct 1264621 gttgtcatca gtaaccatga ggaagcgaga gagctggttg agcgcctgaa cattccattc 1264681 cactatatga aagcgaacaa agacatcaga gcggaagtcg aaaagaagca gcttgaactg 1264741 ctggagcagt acgatgttga tgtgatcgtg ctcgcacgct atatgcagat tctaactcct 1264801 gattttgttt cggctcatcc gaatcgcatc atcaatatcc accattcatt cctgccagct 1264861 tttatcggtg cgaatccgta caaacgggcc tacgagcgcg gcgtgaaact gatcggtgcg 1264921 acatctcatt atgtgacaaa cgatcttgat gaagggccga tcattgaaca ggatattgag 1264981 cgtgtggacc accgcgataa tgcggaagcg ctgaaaaaca tcggaagaac aattgagcgc 1265041 agcgtgcttg cccgtgctgt gaaatggcat ttggaagacc gtgtcatcgt tcatgaaaat 1265101 aaaacaatcg tctttaacta gactgcaaga ggcccgcgca atgcgggcta tttttgatga 1265161 caaaaaacct tgacaagtgt cttttttctt tgcataatat aaaaaaatca ttgagcgttg 1265221 aagaggatta gtaagcagac ctttctgtga cagagagcaa aatgaatcgc tgaaacattt 1265281 tgccgcatga aacctgccga acctgccttg gagtcctagg gggaaaacct aggcgcataa 1265341 cctggcgtta caggagagcg gagcgtgcac aagcgcgttc aatcaaggtg gtaccacgga 1265401 aacccatttc gtccttatga atcaggatga aatgggtttt tttattgtag aagagccgcg 1265461 gaggagaata aatgaaaaaa caaagaatag tagtgaaaat aggaagcagt tcgctcacga 1265521 atagcaaagg aagcattgat gaggcaaaaa tcagagagca tgttcaggcg atttccgtgt 1265581 taaaaaaagc ggggcatgaa atgattctga ttacctcggg tgccgtagcg gcggggtttt 1265641 ccagcctcgg ttatccatcc cgtcccgtta ccatcaaagg aaaacaggcg gcggccgcgg 1265701 tcggacaaac actgttaatg cagcaatata tgaatcaatt taaacaatac tcactgactc 1265761 cgggacaaat ccttttaacg agaaatgatt tttcgaaaag agaacggtat cgaaacgcgt 1265821 atgctacgat aatggaatta ttagagcggg gcgtcattcc gattatcaac gagaacgatt 1265881 ctacatctgt tgaagaattg acattcggag ataatgatat gctttctgcg ttagtcagcg 1265941 gattgattca cgcggaccag ctcatgattc tcactgacat taacggactg tatgatgcca 1266001 atccaaatga aaatcctgag gcgaaacgat ttgattattt gccagagatc acgcctgaat 1266061 tgcttggata tgcaggttca gctggatcaa aggtcggcac cggcggaatg aaatcaaagc 1266121 tgttagccac acaaaccgcg ctgtctctgg gagtgaaagt attcattgga actggcagcg 1266181 gagagcaaaa acttgcggac attttggacg gcaggggaga cggcacttat atcggagaca 1266241 aagaactatc ttcggttaac aacacaaggc agtggattca gttccactcg ccgatatcgg 1266301 gagaaattat cattgatgcg ggtgccgaag aggcgatgat ccataatgga agcagccttt 1266361 tgcccgctgg agttgtgggc gtgaacggaa gctttccgaa aggggcggtt gtggaagtca 1266421 ggggaccggg cggcgtgatc ggcaaaggcc aaactcatta ctcctccgag gagattatgg 1266481 aggctaaagg caaacgcagt gacgaacttg attttgagaa aacgtttgag gttattcata 1266541 ggaatgactg ggtcaatgta aaagactagg aggcggaaaa atgagtgaag tttctgtaaa 1266601 agcgaagctg gcgaaagaag cagcagccga aatgatcatg aaaacaacag ccgagaagga 1266661 tgaggcgctc agcctcattg caaacggact ccgcaaagaa ctggattttc tcttggcgga 1266721 gaatgcaaaa gacattgtga acggaaaaga gaatggttta acaccggaca tcattgaccg 1266781 tctctcattg gatgagaaac ggatacgcga tatcgcggac gcggtggagc tcttaatcga 1266841 cttagcggac ccaatcggcg actctcttga aacgattgaa aaagaaaacg gcctgtttat 1266901 tgaaaaaatc cgtgtgccgc tcggtgtcgt aggaatgatt tatgaggcga ggccaaacgt 1266961 cacagttgat gcggctaccc tttgcctgaa gacagggaac gcggttgtgc tgcggggaag 1267021 ctcctcagcc atccacagca acaaagcgct cgtcagtgtc atttacagag cacttgagca 1267081 atcagcgctt ccgattcacg ctgtgcagct gattgaggat acgagcagag agacagcaaa 1267141 agagctcttt acgttaaatg atggcttaga cgtattgatt ccgcgcggag gcaagaaact 1267201 gattgatctc gttgtgagag aatcaacagt tcctgtatta gaaacgggag caggaaactg 1267261 ccacatattc attgacgaaa cagccaaacc gcaaatggca gaaaaggttg ttgtaaatgc 1267321 caaaacgcag cgcccttctg tatgcaacgc gattgaatca ttgctgattc acaaggcttg 1267381 ggcaagacag cacggaaaag aattgctgga ccagctggaa aacgcgggag ttgaaattcg 1267441 cggtgatgaa ttggtatgtg aacttcatcc ttcaagcaaa caagcatcaa aagaagattg 1267501 ggaaaccgaa tttttagcgc ctgtcctcag cgtaaagacg gttgaaaacg tccaagaagc 1267561 tgtaaagcat atccaacaat acggcaccaa tcattctgaa gcgattttaa ctgaaaatga 1267621 caaaaatgcg gtatattttc aaacggctgt cgatgctgcc gctgtctatc ataacgcgtc 1267681 aacccgcttt accgacggct ttgaattcgg ctacggagcc gaaatcggca tcagcacgca 1267741 aaagcttcat gcaagaggac cgatggggct tcctgcactg acttctacaa aatacatcat 1267801 taaaggaact gggcaaatcc gtgaatagcg gggtaatgtt caatgaaaaa gcttatctca 1267861 ttacgagata agctttttta tacgcgaaaa attgacattt caaatttaat tgtgtacaat 1267921 ttaattgtat aaaatatatt gggggaatga aaaatgagtc agccattatt taccgcaact 1267981 gtttcagcgg taggaggaag agaaggaaag gtcatttcat cagaccgcgt tcttgagctt 1268041 gatgtcgcaa tgccggggac accgagagcc aagaaattag aaaaagcgac aaatccagag 1268101 cagctgtttg cagcaggtta tgcagcttgc tttgacagcg ccctgcagct tgtcgcaaga 1268161 acagaacggg taaaagtaga gacagaggtt acagcaaatg ttagcctgtt aaaggatgaa 1268221 gcggaccagg gctataagct gggtgtgacg ctgcaagtaa aaggagaagg agtcagtgca 1268281 tcagaattgg aggcgcttgt gaaaaaagcg cacggcgtct gcccgtactc aaaagcaacc 1268341 tccggaaata ttgatgtgac acttgaagtt gctgaataaa taaaaagagg atgcctgtac 1268401 aaggcatcct caattttttt gatgaagtgt ttccagtaat gtatatagag cggactttaa 1268461 ctgtttgaga tcctccccag actgctttga gagccccaga attgtccctg gaatgtcaac 1268521 cgctttttct tttaataacg ctccgtcctc tgtcaggctg atcaacacgg accgctcatc 1268581 ctcttcagat ctttttctcg taatcaaacc ctgttgttcc attcgtttaa gcatcggagt 1268641 gagcgttcct gaatctaaat acagctgttc gcccattttt ttgacagtaa gcgtttcatg 1268701 ttcccataac aaaagcaaag ccaaatattg agggtatgtt atattcagct tatcaagcag 1268761 cggcttgtat tgctttgtca tctcccgcga actcgcatat agcaaaaaac aaagctgatt 1268821 ctccaatttc atatgatcaa atttattttc cattttgttc accaactctt ttttgtcatt 1268881 cgattctatt gtatctgaaa aacctcactt ttcctattct cggcaaacat agcatgttta 1268941 aaaagatcag aaagggaaat ataacaacta gatacaaata aggaggttgg gaaatatggc 1269001 actatttaca gcaaaagtaa ccgcgcgagg cggacgagca ggacatatta catcagatga 1269061 cggtgttctt gattttgata ttgtcatgcc aaatgccaaa aaagaaggac aaaccggcac 1269121 aaatccggaa cagctctttg cggcagggta tgctgcatgc ttcggcggcg cgctcgaaca 1269181 cgtagccaaa gagcagaata tcgaaattga ttcggagatt gaagggcagg tcagcctcat 1269241 gaaggatgag agcgacggcg ggtttaaaat cggtgtcaca cttgttgtga acacgaaaga 1269301 tttagatcgg gaaaaggcac aagagcttgt caacgccgct catgaattct gtccttactc 1269361 aaaggcaacc agaggaaatg ttgatgtaaa actagaatta aaataatgac cggcatcctg 1269421 aggattctca ggatgttttt tggtgtcgga catgcggggc gggcacagat ttatgataaa 1269481 acttcagaga agcgtttgaa gcatgccttt aaaccaaaag ttacagatga agcgggtggc 1269541 tggcacggtg tctgccgtgc tgaattgcgc gtatatgctg ttttgtattt gcacagggca 1269601 tagcggctac ttggagaaat aacaaggacc aggccgcgca tgcctgatcc ttttaatatt 1269661 ctttcttatt ggcgaagttc cgccatgctt gaaacgggga taaatgctct gttagtgtca 1269721 cttgataaaa ggggatcgtt ctttcttcag caggtttatc aatttcttta taaatgaatg 1269781 aatcatcaaa cccggcttcg gcagcgtctg tgtgctcagc tgcatagaaa acggctttag 1269841 gccgggccca gtagatggcg cccaagcaca ttgggcatgg ttcacagctc gtatacaaaa 1269901 tgcagtcatc aagctggtag gctcctagca ccttacaggc tttccgaata gctgtgactt 1269961 ccgcgtgggc agtcggatca ttgcttgttg tgacgttgtt ctgtccctct gcaataatgg 1270021 ctccgtcttt cacgataacg gctccaaaag gcccgccgat tcctgcattc actccttcac 1270081 atgcgagagt gacagcccgt tttaagaacg tttcatgatt catcccaatc cctcctgtca 1270141 atagagtgtt attagtatag ccgaaaagaa tgcaaagaac attcttaaaa aagtgcaaaa 1270201 taaacaaagt atttggggga tttgctaaat aagaaaccga ttgtggctgt attatagaaa 1270261 aaaaccatct gccaaatgca gatggttttt tcaaattata ctagctgtgt ctgctgtgct 1270321 cttgcctgtt ttgcggcttc aaccatattt ttcaatgctg caaccgtttc ttcctgctgt 1270381 cttgttttca atccgcagtc tggatttacc cagaagcggt cagtcggaca gacggcaagc 1270441 gcatcaacga taatattgta catttcttca gttgacggca cacgagggct gtgaatgtca 1270501 tatacaccaa ggccaagccc tttcaaatac gggtggtttt ttaagtaatc taaaaatcct 1270561 ccgtggcttc tgctatgttc gattgtaatc acatcggcat caagatcatt gattgtatca 1270621 acgatatctt cgaagttgct gtagcacata tgtgtatgaa tttgtgtctc gtttttcacg 1270681 gaagaagtgg ttaatctgaa agcttctgcc gcccaagtca aatactcatc ccaatcgcgg 1270741 gttttcaatg gaaggccttc acgcagcgct ggttcatcga cttgaatgat ttgaatgcct 1270801 gcgtcttcaa gcgctttaac ttctttgcga agggcaagcc cgatttggaa ggcgatttct 1270861 ttcctcgaga tgtcgtttcg agggaaagac cagtttaaga ttgtaaccgg gcccgtcagc 1270921 attcctttca catgcttgga agtcaatgac tgtgcgtaga ctgtgtcttt cactgtcatc 1270981 ggttcaataa attcaacatc tccgtaaatg actggcgggc ggacacagcg tgagccgtat 1271041 gattgaaccc aggcatattt agtgaaggcg aaaccggcca gcttttcacc gaagtattcg 1271101 accatgtctg tccgttcaaa ttcgccgtga acaaggacat caagctccaa ttcttcctga 1271161 atatcaatcc atctttttgt ttccgcattg ataaagtttt gatactgttc atcggaccac 1271221 tcagctttcc gccatttttg gcgtgcgctc cgcacttcag cagactgcgg gaagctgccg 1271281 atcgttgtcg tcggcaaaag cggaaggccg agagattcat tttgtagggc taaacgttct 1271341 tcaaacggaa tcgggcgctt gaagtcttta tcagttaatt gctcaagctc tttcttttgt 1271401 tcagaattgg cgcctgttgc aaactgttta agcgcctgga tatcagcctt agcctgctga 1271461 atctcttcgc tgatcgccgc ttttcctgat actaagcctt ctttcaaagc tgtcagctcg 1271521 gccagctttt cttttgcgta ggataatccg ttcaataggt ctttttccaa atgctcatca 1271581 gggtgtttcg ctactggaac atgcagcagg ctgctggaag gctgaatcca cagttcatca 1271641 acttttgcaa tgctgagaat atcaagaacg gcatcgagac gctcttcaag gtccgctttc 1271701 caaatgttgc gtccgtcgat aacgccggct gccagcactt tatctgtcgg gaagccatgt 1271761 gttttaagct gttccaggtt tctgcctttg tcgtgaacga aatcaaggcc aattccctga 1271821 accgggtaag agatcagctc ttcataagca tcaacagaat caaaatacgt ctgcaaaagc 1271881 acattcaagg atgaaagctc acttgtaatg ctttcaaata attcttttgc gccgcgtaca 1271941 tcttcactag aggcggtaac gagcgccggc tcatcgattt gaacccattt tacgccttct 1272001 tcttcaagct ctttcaaaag ctgtacatat aatggcacaa ggcgtttttg gatcgctttt 1272061 gcttcagacg gttcatagcc tttagcaagc gtaacgaacg tataagggcc gacaatcaca 1272121 ggctttgttt ccacaccgta ttcctgtttg atccggcgat aatcttcgag ttgtttgttt 1272181 cttgtcagac ggaactcaat gctctcgtca tattccggaa cgatgtaatg gtaatttgta 1272241 ttaaaccatt ttgtcatttc actagataca gcgtctttga ttccgcgggc gatagcgaag 1272301 tatgtatcgg tagcgtcagt caaatgtctg aaccgtttcg ggatccagtt gaagctgact 1272361 gctgtgtcga gtacatggtc atactgtgtg aaatcagaaa caggcacaac atcaatctgc 1272421 tggtcaattt gtgtttttac tgcggataaa aatagttcgt cgatttgctt caaaaacgta 1272481 tctttatcag tactgccttt ccaatacgct tcaagtgctt ttttccattc ccggttcagt 1272541 ccgattctcg gaaatcctaa attcgatgtt ttgatggttg tcattgtttc tcctccttta 1272601 tatgtaaaac actctctttc acccgcggat acaggctgct aagaggtttt ctcacaacaa 1272661 aaagcctctt tcccatgaga gaaagaggct tttctacgta aaacactgcc tctctcatct 1272721 ctcagacaca atctgatgga attagcaccg tgccttatga gacatcagtc tcggcgcgaa 1272781 aagcagtgcg ccccatttca caatggtatt acggtcggtt gctgttgggg tcaaaaggcc 1272841 aatccctcgc ccaactctcg ataagagaaa atgttattaa ttttttgaaa agttgaatca 1272901 tttgttggta atcttaacag taattcaaat tcattgtcaa catagaattt gaaattttta 1272961 tttacatgat gtggtgtata ttatataaga aaaataatct tatagggtca acaaatgtga 1273021 ttgctctgct ttttctgcga gctcatcagg agctgttaaa tacaggaatc cattgcctgc 1273081 cagcgttttt gcaatatcaa gaggaagtgt cctgcggatt agctgtgcga aaacctcaga 1273141 ttcagaaagc tttctttgaa atgattcttc ttcatagctt ttgattaaag caagcgcacc 1273201 gctgacatga ggggcagcca ttgaagtgcc ggtcagctta ccgtacttct tgttgggaag 1273261 ggtggataag atgttttctc ctggtgccac aaggtcaatc tctttattcg cgttagaaaa 1273321 ttctgataat tctcgcgcta cagaaacaga tccaactgca atcacttcat tataagctgc 1273381 ggggtaggaa agctcttctg tgcgttcgtc gccgtcacct tcatttcccg ctgcacaaac 1273441 gacaagcact ccgtttttca ctgcgttttt cactgcttct tttagctctg gcacatcgct 1273501 tggccctcca agggacattg agatgatgtc gactttctgt tccaccgcgt agttgatgcc 1273561 gttaattatc cattcgtatt gtccgctgcc gttctcgccg ccaagaacct tcacaatcaa 1273621 taggcttgcc tcaggcgcga ctccggcaat gcctccgttt gaatcattag ctgcaattgt 1273681 tccggcgacg tgtgtgccgt gtccgttgta gtcggaaatc gcatcttcct tgccgccgtc 1273741 gtcatccgtg aagttctttc cgccgatgat ttgatttttt aaatcagggt ggcttgtgtc 1273801 gcagcctgtg tctaatacag caactttaat atttttgcct tttacccctt ttgcccacat 1273861 ttctggcgcc ttaatcactt taatgccctc aggaagctcg tttacatcca tgatctgctc 1273921 attcgtcaca tacgggatca agcggatttc accattcata aaaaagccct ccttttttat 1273981 gcttgcaagt ggattcaagg gtgttgcctc atattatatg aaaaaagcaa gcgctcggac 1274041 agagccattt gaagcatttt gaaaaaatag gatacacacc aaagaattag taatcttcaa 1274101 aatattggat ggcttcaaca tgtatgactg ggattcaact gtaagtcaag ttataatagt 1274161 gttggggaaa ggagcagtgt catgaaactg aatgaaaaat tatatgcatt tttttcagag 1274221 catgtggaac aaatggccga ggaatggatt gaaacgatgg aggaaagtga tccgaattcg 1274281 ctttacgccc tacataatgc aacagtaacg gaagaattga aagagcagga cagagaattt 1274341 taccggcatc tgaattacat gtatgtttta ccggaaaaac aatttctcga agagtttcaa 1274401 gagtgggtca ttgagctgac caacgatcaa aaacatctcg acacaccggt tcagtatgtc 1274461 attcgggagt ttatgagaaa caggagatta tatacgaagt attttgagaa gttcgcagaa 1274521 gaaaatgaat cagcgtttga accgggagag aagcaaaaat gggcagattt gattgtaaaa 1274581 gtatttgatt tcaccattta tacattcgtt gatcacgctg aaatgaatgc caagcagcaa 1274641 ttaaacgccc aaagagaaat gatattggaa ttaagctcac ctgtcattac cctgagcaaa 1274701 tcaacagctc tgctgccgct tgtcggtgac attgataccg aacgggcgaa gtttattctg 1274761 gaaaacacgc ttcaagcttg tgcgaaaaga cgtgtggagc atctgttaat cgatctgtca 1274821 ggtgttgttg tggtggatac gatggtggcg caccagatct ttaaattgat tgaggcgctt 1274881 aatctgatcg gtgtccggtc aaccctgtca ggaatcaggc ctgaaattgc gcaaactgct 1274941 gtacagctgg ggattgactt ttcgaatatt actattaaaa ccaaccttgc ccaagcatta 1275001 aactatcatc aataaaaaaa tccgctatct gtgatagcgg attttttatg atgcgaaaca 1275061 taaagatacg agaaaggatc ccgcgaataa taagaggacg aggcaaaaga acacccagtc 1275121 gcgccggttc acgctcaatg tcctgtagta tgtccggttt ctgcttcctg taaatccttt 1275181 cgattccatc gcaagcgctg tccgttccgc ttttctgatg gcgcttgcca atagcggtat 1275241 ggtatatcgt tttaacgcac tgattttatt aatgatgccg ctctccgccg ctcctcctct 1275301 gattttatga gcctgctgaa tcagctggac ctcatccttt aacagcggaa gaaagcgaaa 1275361 gcctgcaatg acaccgtacg cgagctttgg tgagagcctg cactgctgga caaggctcag 1275421 cataaataga atcggatcgg ttgtaaaaac aaacatcatc gataaggcgg aaaagcataa 1275481 aatacgaaac ccgagagaga tgccgacaga cacattatcg ctgttaatgg agatagggcc 1275541 tgcttgaaac aaaaaattat ccggtgttgt cggcactttt ccaaaaactg cggctgtcca 1275601 cacgcatccg aatgctaaaa tcaaaaacgg aatcgtaaac aacaaccatt ttttcaatgg 1275661 gattccggcc gccagtaaaa cgcccgcaac gatgatgata taaaaacatg ccggagtgta 1275721 agggttgtaa ataaacgaca gcatgacgac acaacaaaaa accgccgccg ctttcacagt 1275781 cggattaatg agatgtaacg gttgcttcat cacgcacctc ctcttgaaat gccatccatt 1275841 catatagaag gggaagggtg agctttgctt tttgaacaag ccctgtttct tgagaaaaca 1275901 actgcgctgg agatccgtca aaggccaggc ctgtatcgtg aagcacaagc acgctgtcag 1275961 catacgaaga gactagctcc atatcgtgtg taatcataag gacagcagtt ccctctgcct 1276021 tgatacgttg aatcatttcc atgcattcag ccgccgtgcg ggcatcctgg ccaaaggttg 1276081 gttcgtctaa taataaaacc tttacgtcat gcatgagcat agtagctacg ctcagtcgcc 1276141 gtttttgccc ttggctgatc gcaaacggat gatgatcagc caaatgcgca agaccaaaac 1276201 gctgcagcag gtgttgcgct tttttctcag tttcagcatt tgctttctgg ccgaacagaa 1276261 gctcgtcata caccgtatcg gtgacgaatt gatgctcagg gttttgaaaa acaaatccca 1276321 tccgtttacg caattctttt tctttatatt tctgcagcgg ctgatcatag agaaggattt 1276381 tgccgctttg cggtttcatg agactggcca gaactgatag gagcgtcgat tttccagttc 1276441 cgttcggacc gacaagcgcc gttaaagagc cttcgcgcaa cgaaaagctg atgtctttga 1276501 aaatcgcctg ctgtcctctc gcgaacgaaa ggctgctgac ttcaagcaca ctctccccag 1276561 aaggggcttt cttctttttg acatgcccgg caggaatagg ctctttgaac agcatctctt 1276621 ttgataaagt aaacggcata ctcagctttt cctgcagatg acagaccttt ggaatggcga 1276681 tgcccaattt ctttagtgtc tccgcttcat gctgaaatag atttttcgtc aggccatcca 1276741 gtgccttttt gcctgatttg tcgagtacga tcgttctctc aatccaaggc gcccattcat 1276801 caagctggtg ctcaatgacg aggaggctga aacctttttc ccgctgaaga tccttcatca 1276861 gatgaacgaa ctcccgagct gagaaagggt ctaaaagaga ggtcggctca tctaaaataa 1276921 taagctcagg ctccatcgcc aaaatacagg cgagagccac tttctgcttt tgtcctcctg 1276981 aaagggttga gatcattttt tcttttaaat gggtaatgcg taatttttct aatacggcgt 1277041 tgattttctc tgtcatttct tcttttggaa tttgcagatt ttccagcccg aacgctattt 1277101 cgtcctccac cgtcagcatg cagaactgct gatcaggatc ctgaaaaacg accccggcat 1277161 gctgagtaat cgtttcggag gtttcagcat ctgtgaccgg cttttgaaat agaaatacat 1277221 gtccggactg aatgccgtcg caagcctccg gatatagacc gtttaaacaa agggcgagcg 1277281 agcttttacc gcatccgctc ggtcctaata ataaaacaca ttctcctttt tgaagctcaa 1277341 acgaaatgtc ttgaaaaacc ggtttctcgt cttcttcata agagaagctg agctgctcaa 1277401 ccgtcagaag ctcatcaaag gcttgcatgt tctgacgccc gcttccgttt ctttttcagt 1277461 tcctttccga gtgccattcc gtttaacaca cctgtataag cgagagagtc gctgacagct 1277521 tttccgagaa gccccgccaa aagcgcgccg gaaatgaggc ggatcacaag cataatgagc 1277581 agataacctg gtgaataggc tgcatagcca gaaacaaaga gatcatagat aaagctggct 1277641 actgaagacc ccataccggc cagcataagg acagggagag agtatgcttt ccagcgtgtt 1277701 gcaagaaata cagcctcagc cccgagccct tgaacaatgc caatgacgat gaccatcggg 1277761 ccagacggat ttcccagcag gcactcaacg agagcggcaa tgatttcaga aacgagcgcc 1277821 gcacccggtt ttcgaatcat gtacgcggcg atcacagaaa cgataaacca aatgccgtaa 1277881 attggttcat aggcgattgg cccaaacata cctgcaagta cgtttccgaa atgtgtaaat 1277941 aataaataaa caacggcaaa tacgatactg ataacggaca tgatgacaat ttcttttact 1278001 ttccagcttt tcatgttatc cctgctttct gttttttctt gatggactgt tagccgaaag 1278061 attcacagtc atggtgatgt ggtttgtttg ctgctcagcc atgcggaaaa cggcctccaa 1278121 tgtgctgaat acgtcatgcg catccccgtc aagctcgctc gcgtaatgga caccctgtac 1278181 gaaagtgcct tgggcttttg caatgtcgac agcctccata atcaatccca tataatccgg 1278241 ctcattcatt ggataaaggg caaattggca cggcgcttcc gccttcaagc ctcggacagc 1278301 atcttcattg acacgcttat cacctttgga aagatatgta tccccctgtg tgtcacccgg 1278361 gcatccaatg gaaaacgtgc cgttcatgac gatgtgttgt tcgctgtttg ctgcatgaag 1278421 gtaaatggct tttgcagcat cgaatacatg atcaatcgat ccgcgtaaca ccgtgctgat 1278481 atggtcggtt ttcgtccaaa ccttggatgt atctgttttt ttcagcgcag acttgatcac 1278541 actgataaaa tcatccgtca tcggatataa agagaagcga aaaccggcga ttctgcttgt 1278601 accgcaaata tgctccattt ctccgacctc ctgttttttt ggtaaaataa aaaactgcat 1278661 atcctaaggg aatatgcagt catagatcga ttaagcgcac aaaaaaatac accattcggt 1278721 caacctgcac ttccccacgc tggtattatc cagatcgggt cataagggat caaagcgcgt 1278781 ttcttccgcg ctttatctca gccaaaacag cacccctagt gctttccgta tacaattttt 1278841 tattttgaca tcataataga tgataagaat cattttgtaa acaacgaaat catttttttc 1278901 atatagggac gggagaggat ggtcaaattt ggaaaaagga cacatattaa ttgtggaaga 1278961 tgaagaaaaa atcgccaggg ttcttcagct tgaattggaa tatgaaggat acagcgtcac 1279021 gatcaaacac aatggcacag aaggtcttga tgcggcagcg gaaggcgggt attccttggt 1279081 gcttcttgat gtcatgcttc cggggcttag cggactggaa gtgctgcgcc gcttgagaaa 1279141 aacggattcg cagacaccgg tcatattatt aacggcgcga gacagtattc ctgataaggt 1279201 aacaggtctg gacatcggtg caaatgacta tgtcaccaag ccgtttgaaa tcgaggaatt 1279261 gcttgcgaga atcagggcgg cgctgcggca aaatggaaca aaaactgaag atatcggcac 1279321 ctttcttaca tatgacgatt tgcgggtgaa cgaaaaaacc cgtgaagtga gacgcggaga 1279381 caaagaggtg gaattaacgc cgcgggaatt tgatctgctc gtctatatgc taaagcatcc 1279441 gcagcaagtg ctgacacggg agcaaattct aagctcagta tggggatttg attatatcgg 1279501 tgatacaaat gtcgtggacg tctacataag atacatcaga aaaaaactgg actatcctta 1279561 cgaaaaacag ctgatccata cgattcgcgg ggtcggctat gccattaagg ggtaaacgat 1279621 gaagctgaag accaagattc atctatacac ttcgatatca ctgttgattt tattaatttt 1279681 ggttcatacc gcagtatatc tcattttttc gtctgcgctg acatcaaagg atgcggcccg 1279741 gcttgctgat gagacggata acattgccga agcgctgcgt gccgctgaaa cagaaggagt 1279801 ggctttgcag gatatgctgc aggcctatct tccggcaaat ggcatggtgc gtgtagtgaa 1279861 tggtgatcaa aaagccgtta tgacgatcac aaaagaaaaa gcctataaag attttcctct 1279921 ctcttttcat agcggcgaaa cggcagatgt gaggaaacct gacggcaagc tgtttgccga 1279981 ggctgctgtt ccggtgattt ggaccgatgg acaagtcgtg tctcttcagc tggttgaaag 1280041 actggagaac acagaagaga gtctgtttct gctgaaaatc atcttaatcg ctgcaagtgc 1280101 tgctgtctgc attgcttctt tttttgcagg cagcttgcta gcccgccgaa tcatcaatcc 1280161 gatcagacga ttaatgatca caatgaaaga catacagcga gacaaagaat ttaaaacgat 1280221 ttctttagaa ggacagtcca acgatgaatt gtatcaaatg gggctgacat ttaatgaaat 1280281 ggcaatgatg ctgaaggagc actatgataa acagcagcaa tttgttcaag atgcttcaca 1280341 cgaattgaaa accccgctca ctattataga aagctacagc agcctgatga agcggtgggg 1280401 tgcaaaaaag ccggaggtgc ttgaggagtc gatagaagcc attcactcag aagcggtgca 1280461 tatgaaaaaa ctgaccaatc agcttttggc gctggccaaa agccatcaag gactcgaggt 1280521 tgatctgaaa acaatcgatc tgattaaagc ggcgcgcgcg gttatgcaaa cgctccagtc 1280581 cgtttatcag cgtgacatat tgcttgaaac agataaagag agcctgcttg taaaggcaga 1280641 tgaagaacgc atcaagcagc tgttgaccat tttgcttgat aatgcaataa agtatagtga 1280701 aaagcctatt gagatgtcag ccggaacgag gaatggacgg ccatttctat cagtgaggga 1280761 tgaaggcatc ggaatacctg aggagcatat cccgcatttg ttcgaacggt tctaccgggc 1280821 agatgaggca cgaaacagaa aaacaggcgg aacaggttta ggcctttcca ttgccaagca 1280881 aatcgctgat gagcatggca ttgagctgtc tgtcaaaagc aagccgggac aaggaacagc 1280941 tgtcaccatg caattcagcg aacagaatgg gggaggccga tgactaaaac aataaaaaca 1281001 gtatcttttg ctgcagcagc cattttagtt gtcatcatct gtacgtttct catcattcgg 1281061 caaacccatg agaacgtatt gtcaaaggag actgtcgtaa aaaaagtcga agcctcttat 1281121 gaaggcaagg tcacgaaagc aacacaatca aaggataaaa aaacatatga tataaccctt 1281181 gaaaatccaa agggaactta ctttgtaaaa gcagacgcaa tatcggctga cattctttca 1281241 atgaatagag taaaagcagt gaatccatct gccatgacag aaaaagaagc cgagcatctc 1281301 gcgcttgagc gggtgccggg aacggtcaaa aaacaaacac ggcaaagtca agttgccact 1281361 tataccatac aaaaagaaga cgggaaaaca tacgaagtga aggtagacat gcaggcaaaa 1281421 acagtcttgt ctgccgatca aatcagcagc aaagatcaac aaaaaacgcc gattacgaaa 1281481 aaagaagcca aaacaattgc agagcgaaaa acgggcggaa cagcggatga cgcagatctc 1281541 gaagaaagtg agggcactct catctttgaa gtagacgttg atcttcctga taataaggaa 1281601 gcgacagtga aaatcaatgc ctacacagga aaggtagcta acattgtgta tgaagactga 1281661 cggtttctca tcaaattctc atcttgctct cgttttcctt tcatgttgag tatgtaaact 1281721 gtactcatac aaaacaaagg agggctcaca aatgctcaag aaaaaatgga tggtcggtct 1281781 tttagcaggg tgcctagcgg ccggaggatt cagctacaac gcgtttgcca cagaaaacaa 1281841 tgaaaacaga caggcttctt ctaagacgga tgcactcact gaacaagaag cagaagcaat 1281901 tgctaaaaca gttgttgacg gcacagtaga agacattgac agagaccttt acaacggcaa 1281961 agaagtctat gaagtggaga ttgaaaaaga aggtgaagac tacgacgttt atgtagatat 1282021 tcatacaaaa caagcgctta atgacccgtt aaaggagaaa gcagaacaag tcgccataac 1282081 caaagaagaa gctgaagaaa ttgctttaaa gcaaacaggt ggaaccgtaa cagaaagtaa 1282141 gcttgacgaa gatgacggtg cttacatcta tgaaatggaa atccaaacga agcaaggaac 1282201 tgagacagaa tttgaaattt ccgcaaaaga tggacgcatt atcaaacagg agatagatga 1282261 ctaatcaaaa cccccgctgc agcgggggtt tttcatgata agaaaccttc ttttggacaa 1282321 tctaagtaga aaaggaggcg aaacgcatgg aaaagaaaga ggagcaatac atcaatcagg 1282381 ctgaatatgt ccctcatccg acgaaggaag gagagtatgc cttatttctt catgaaacgt 1282441 atcatttgct ttctgaagat gacgagacac aaacaacaga ataagggctt aggcccttgt 1282501 tttgttccgt aattgtgatg taagcgcatt tattactttt ttgagttgac atagcttgtt 1282561 tttttctgta atctcagtgt gtcaattcaa ttaggaactt cgttaggtga ggctcctgta 1282621 tggagatacg ctgctgccca aaaatgtcca aagacgccaa tgggtcaaca gaaatcatcg 1282681 acataaggtg atttttaatg cagctggatg cttgtcctat gccatacagt gctaaagctc 1282741 tacgattgaa ggcgcccgca cgcttttttt gccgtgcttc tttcaccttc aatcccgaag 1282801 gcttttttta tgcctttaaa acgaaaccaa tcaaaggagg tgcggagtat ggattctccc 1282861 cattcgagtc aatctgaaga agtacccata tactatgaca gcaagacaat tgattacacg 1282921 atgaggagac gaactgccgc accttctggc gaggccggca cgtctccgta gaggaggtac 1282981 gagtcccgat ggttcaaaac atgacctatg acgaactcat tttacgcatc attattttac 1283041 tgcgagacgg gaaaatcagg gattttagaa gtgttattga tgagcttcag ccctatgaca 1283101 tggcatttat ttttaaagaa atgccggaaa aacatcgcgc ccgctattta tcttatttaa 1283161 ctgtagacga tatcactgat atgatcgggg agctggaacg cgaatttcag cttgtcgtct 1283221 taaataaagt cggaaaaaca aaagcaacac tggcgatgaa caaaatggac aacgatgacc 1283281 tcgctcaatt gcttgaagaa atggacgaag aactgaagga acagctttta tccagcatgg 1283341 aagcgtcaga atcaaaagct gtacagctct tgatgaatta cccggctgat tcagcgggac 1283401 gcatgatgac aaaccggtat gtgtggatcc ctcagcatta cacggtaaaa gacgcggtcg 1283461 tcaaactgaa aagcttcgct gaaatagctg aatcgatcaa ctacttatat gttattaatg 1283521 aaagcaaaca gctggttggg gttctttcct accgcgattt gattctgggt gaacctgaag 1283581 aaaaggtgca ggatttaatg tttacccgcg tcatatcagc agatgctctt caggaccagg 1283641 aagaagttgc ccgcctgata gaacgttacg attttttggc aataccggtt gtagaagaaa 1283701 acaacgtgct tgtcggcatt gtgacggttg atgatattat cgacgttgtt attcgggaag 1283761 ctgatgagga ttacgaaaaa tttgccgctt ccggtaaaga catcaccttt gacacaaaag 1283821 cttacgtggc ggcataccgg cgtctgccat ggctgatttt actcttattt atcggactga 1283881 tttcaggaag cattatcagc tattttgaag acgcgctgaa gcaggttgtc gcgcttgcgt 1283941 ttttcatgcc gatggtgtca gggatgacag gaaatacggg aacacaatct cttgcggttg 1284001 tcatcagagg tttgtctaaa gaagaaatga acaaaaaaac gattgtgcgc ctgatcttcc 1284061 gggagttcag aacaagcatt tttatcggag cggtttgttc tgtgctgatt gcgattgttt 1284121 ctatcatatg gcaggggaat gcgcttttgg gatttgttgt cgcctcttca ctgttcttaa 1284181 ccttaatcat cggcacgatg tcaggaacga ttatccctat tattttgcac aaactgaaag 1284241 tagacccggc gattgcttct ggaccgctga ttacaacgtt aaacgatatt ttatctttat 1284301 taatctactt tggcattgcc actgcattca ttcactcatt ataaacgtaa aaagtccgtc 1284361 tcaactgcga gccggacttt tattatttaa cggtttttgt accgaaagtg agcattaagc 1284421 tgcccctcca gcattttttt ccgcacttgc ggatcgtttt ttaacatctg ttcttttttg 1284481 cgcatatcct ttaaaatctc tgccgtctgt acgccgtctt cacgcttatt ggcgatatcc 1284541 atcagccgct ccacatcggc aaaggagtat tttcttgtcc cccttgaaga acgctgcggg 1284601 taaatgagct ttcgttcctc ataatacctg atctgtctta cggacaatcc tgtcaattca 1284661 ctcacaattc cgattgaaat cacttttttg tctttataag aatgatcttc tgtggtcatt 1284721 tttccacccc tggatgtctt ttgataatag tatataaaaa acaaagagaa aaaacctgac 1284781 gcttgtcata ttttctaaca tcaaatagaa gatttttgaa aaaatacgga agaaaaatta 1284841 acaagaataa tgcgtaacac ccaagcgcgt tttatccttt atgtaacgaa tcaaacgagg 1284901 aggaaggata atcatggagg aagaaaaagc agtctcactg gcaaaagaaa ttatagagtt 1284961 ggatatcaag cgtgatgaaa tgctggagac gtttatgcag cttgccggag aacaggcttt 1285021 tcaattatta agatcggttc aaaacggaca ataccgaaaa tcttcgtaaa cataaattct 1285081 ttacattaga ttcataccac gttcatttaa aaagagtatc ttttgtatag gatacctcaa 1285141 aatgaaggag gacgctatga gtaatttatt gaaatccgct ttagaaaaag aacgacgcca 1285201 ttattctgaa aaactctatc agataggggt ttataataaa gaggtcatga acaaaatgac 1285261 gatttctgag cttcggaaag aatacgctta tttctttcga agcattacaa atcataaaaa 1285321 ttatccttat acaagataat gtataaggat ttttttgctt ttagaaggaa tttctcgaat 1285381 tatagcgaat acgtatagta agggactgaa ctcttattat atgtaagggt tttcattatt 1285441 tttttataaa aatcctatat acgaggtaga tatgatgaga ttatcgttta acgaagaaga 1285501 agttgagcgt gcgatgaatt tgtacagagt ttttgcaagg gctttcaaaa gtgtgtccga 1285561 acatagtatc cgtgatagca aagagcacgg ttttaatccc actgaatttg ctgtactgga 1285621 actcctgtac acaagaggcc cgcaaaaatt acagcaaatt gggtcgagac ttctgcttgt 1285681 aagcggaaac gtcacatatg ttattgacaa actagaaaga aacgggtttt tagtaaggga 1285741 gcaggacccg aaagataaac gctctgttta cgcacattta actgacaagg gaaatgagta 1285801 tttggataaa atttatccga ttcatgcact gcgtattgcg agagcgtttt caggtctttc 1285861 gcctgatgaa caggaccagc tgatcgtcct gctcaagaaa gcaggcatac acagccagca 1285921 tttgctgttt cgttaactat tctacactct ctatttcagg agagtgtttt tttgtttcca 1285981 tatgattctt tttaaaacat ctttaatctt cctatcagac atttcgccaa ggtatccatt 1286041 gacgtgtttt ttatactcct tcatctgttc gttcgattga aaaaatgccg cgatatactc 1286101 ttctgctttc tgcatgtccc agtttctcat atctgtgacg agtttccttt catgtagaag 1286161 gtttaaattc atttcctcct gtcccggcag tgcatgataa ataaataccg gaagccgttt 1286221 ctgtaagcat tcactgatgg tcacgcctcc gggtttagtc atgatgcctg tcgcctgttc 1286281 gtacaaacgg ttcatctctg ctttgctgtg aaggtaagga atcgcctcaa tcaaggggtg 1286341 gtgtaaactt ttgacatagg agtagagctt ttcgtttctg ccgcataata ttttgtataa 1286401 gatctttccg cctggcgaca gttcctgcac ccattttaaa atcccaccga cccccatact 1286461 gccccctgtg atgatgatgg tatatggcgg gtggtgctgc aaggtatctg ctgattccat 1286521 ttcaaaattt tggtgaactg gaatgccggt caagtatatg ttgttctgat cgataccctc 1286581 tgatattagc tgcttcttta cttccgtgct cggaacaaaa tggtaatcaa tgttcttccg 1286641 tccccataat tgattcacga aaaaatcagt gtatacattc acaaccgtca gattcggata 1286701 ttcaggcttt agtcggttca gcagataaga aggcagcgca tgtgtgcaga aggcgatatc 1286761 aggctgtttt tcttggagga tgtgcctcat ttgctgtgtg aacagccatt cgtacatgaa 1286821 atagcgtttg tcatgctgaa attctccgca ggcgaggagc ctgtaaatgc cgctgtacgt 1286881 tttcgggaaa tattgaatcc attttaaata agccacggag gacaattttt ctaaccgcct 1286941 atacgaatgt gaaaagatat caatcttttc agctgccagc ccttgagact ctaattcagc 1287001 ctgcaatgca tcagccacat gatgatggcc ggtggaaatg cttaaaaaag gaaaaatgag 1287061 aatgtttttc atgacagtcc tcctaaaaaa atatggcaac tatattttga ggagaacgtt 1287121 cacaaaatat aagggtgttt ttgatcataa ggaaggtgaa aagatgaaaa cttgtttcct 1287181 ttccatatgg agagtggttg atccgattta tttctttttt tcaaggctaa gcttgattga 1287241 caacgatcaa aaaagcgttt ttcgagtcag gctgacgaag tacaaaggac atcatgtcgt 1287301 gcttagcgac ggaacgcata taagaaaaaa tgatgtgctc gttaaaatcc acctgcataa 1287361 cataaagctg atcagggagc tgcaaagcat tgagagcgca gtcagaaagg gaatcattat 1287421 ttatcagaaa gtatatcaat cgatgccgct tcttcttgac tatatcaaca atcataaaaa 1287481 aagcgagaaa atcaaaggaa tcattgggat tacaatgctt gacaaaggtg tggaaaggct 1287541 cggctttgat gtgatcaccc cggtgaaccc tttttacaga tgctttaaaa aagtgtctca 1287601 tgtgccgatt ttatatttga cttcaaagcc tgtgagcttg cggcatttac cgaattcatc 1287661 ctatttgttt atctcaaaag aaaagctgca gaaaacctat caaaaaaaag actgatgcct 1287721 cggtcagcac agtctttttt gattaaatct gatgaaatgt cacttcaggg cggcttccga 1287781 cacggatatt tacgccggtt tgtcccaagc cctcgctgat ataaaatggt ttatcgtgat 1287841 gataatgaag gcctttaatc atgttcattc gcacgagctt tcccattttc accaaatgat 1287901 acggttttgg ccagtgaatt tgcccgccgt gaaaatgccc tgacagcagg taatcataat 1287961 gaacatcttt catatccaga ataatatttg ggtcatgtgt taagacaaga tgatagccat 1288021 tttccagact ttgataagag ccggtgatat tactccgatt cgtactgtaa tcatcaatgc 1288081 cgataatatt gactggtcct gcagccgtct cgattcgaac atgttcattt tgcagcgtga 1288141 tacagccgtt ttcctctaaa actcgcttca atctctgaaa gtcctcttct ttcaatacat 1288201 aatcgtggtt accgaacacc gcgtacattc catatgcagg ctttagcttt tgcaaggcgt 1288261 tcaagtaacc tgccagtttc ggaatattac gtttccgatc aagaaaatcc ccggtaagag 1288321 caatgatgtc cacaggctga tcttttgtta aatgatacag ctcctcaggt gagactgaaa 1288381 tgttttccaa gtgaagatca gataaatgaa ggatatttaa tttttttctg gctggaaggc 1288441 cgtctttttg gtcgattgaa atggtgttga ctttcacatc ttttgtattg cggttcgctt 1288501 tatatagaaa tggcacaaat acgagtatgg ccaatgaaag taagattgta aacaaaatat 1288561 atcccctccc ttctatcagt atagtaagtg atcaagccct atggatagcg ggaattaatg 1288621 ggtagagaca ggttgaaaaa cggattgtca tatgatgaat gatttggaag ggaaaaggga 1288681 taataaattt tgacacatga ggcagaacat gccgacggag tcagaataac aaatggatgt 1288741 gtaagcaatg ttacgattga tgagacaaca aaaaaaagaa acatattatc tctggatcgc 1288801 attatttctt cttttattgt atgtatcccc gctttttatt ttaaaggaag atgcccatat 1288861 ccgggtccac gataatttag attccaacat cgcttggtac aaggttctgg ccgatagcgg 1288921 agaaatcgtc ggcaaggttg acgctgccat tccgcaaatc attaacgggc tgccccggga 1288981 tgcctttggc accgagtgga gcggaattgt ttggctccat gctttctttt cttccatgac 1289041 cgcctatgca ataagccaga cggttacaag agttgtcgct ttttttggaa tgtatgtgct 1289101 gctgaagaaa catataatcc cggaaccaaa agcggctttc atccgaattg gcgtatcgct 1289161 tgcatttgcc ttaacaccgt tctggccttc gggaatgctg agtacgcttg ggtacccttt 1289221 ggcactgtgg gcttttttaa atatccgaaa aggggatatc tcatggagag agtggctgac 1289281 gctgggcttg ctccctctat actcaagctt tgttctaggc ttcttctttt tcctggcagg 1289341 gatggcgtgt ttttggctgt atgatgccat tacaaaaaga agatggaatt tgatgttctt 1289401 aggcagtatt gcatttatga cgagtatcta tcttttcgtt gaatatcggc ttgtctattc 1289461 gatgctgttt gagcacgcac cgatgcatcg tatcgaattt atctcatcta ggcatgacgt 1289521 ttggcattct cttcgactat ccataaaaaa ctttgtctat ggccataatc atgtgatgac 1289581 cgttcatacc gttgtcatcc ttccgatcct gatggtcgta tttgctgctc tgctgttcaa 1289641 acgaaatcgg acaaagccag aaaatgttta tctgttttta tgtgtgctta attacgggtt 1289701 gtcattatgg tatgcgtttt ggttcaacaa aatttgggct gttccaaagc agaaatttgc 1289761 ttttttagca gaatttaatt ttgcccgttt tcattttctt cggccgcttg ttatatacgt 1289821 gagctttgcg cttgctttat atctcatttg gcggatgggg aaaggatgga aatggcttgt 1289881 gtacgccgca gtcgctgcac agctgatggt gttggcgcct tttaatgaag aatatacgta 1289941 tggtgttcat tacaacgcgc cgacattcag ggagttttat gcatcagagc aattcaaaga 1290001 gattaaggaa tatatcggac gtccgcaaga ttcgtatagg gtggcgagca tcggactgca 1290061 tccgtctatc gcccaatata acgggtttta tacgttagat acgtataaca atctgtatcc 1290121 gctctcatat aaatatgaat ttagaaaaat catcgaaaaa gagctggaaa aaaattctcg 1290181 gctgaaacaa tactttgatg aatggggcag ccgctgctac ctttttgtcg atgaactcgg 1290241 taaacgatat gatttcaaaa agaactcgaa gaaaacgatc aacaaccttc aattaaatac 1290301 agatgtattt aaaaaaatgg gtggacggta cattttttct tcagttccga tcatgaatgc 1290361 tgaacaaaac catctcgcgc tcgtaaagac gtttgaccat aaagattccg cctggcgcat 1290421 ttatttatat gaaacaagat aaggaggata tcgattgaaa cagtcacagc cagtattaac 1290481 catcgtcgtc ccgtgtttca atgaagagga agtgtttcaa gaaacaagcc atcagctgac 1290541 agaggttgta gatgatttaa ttgaagaaaa attaattgct gaagacagta aaattctgtt 1290601 tgtcgatgat ggcagcaaag accgcacttg ggctttgatt gctatggaga gcataagaaa 1290661 caagaaggtt accggcttaa aattagcctg caatgtcggc caccaaaaag cgcttttagc 1290721 cggattgcat aaagcgaaga ataggtcaga ctgcgtcatt tcgatcgatg ctgatcttca 1290781 ggacgacatc tctgtgatcc gggattttat gctgaaatat catgagggct gcgagatcgt 1290841 ttacggtgta cgccggagca gaaaaaccga tacctttttc aagcgcacga ccgcgttagg 1290901 gttttatcgt ctcatgaata aacttgggat taaattaatt tataatcatg ctgattttcg 1290961 tttaatgaat aaaaggtccc ttgaagagct tgagcgttat ccggaagcga atctgttttt 1291021 aagaggtatt gtccccatga tcggctttaa atcggccgaa gttttgtatg accgcaagga 1291081 acgctttgcc ggcaaaacga aatatccgct gaaaaagatg ctatccttcg cttttaacgg 1291141 gattacttca ttcagtgtcg caccaattcg attctttacg cttttagggt ttgttttgtt 1291201 tttcctcagc gctgtggcag ggattggcgc gtttattcaa aagctgctcg gccatacgaa 1291261 tgcaggctgg gcgtctctta tcatatccat ttggtttttg ggcgggctgc aattgatggg 1291321 aattggaatc atcggagagt atattggaac gattttttct gaagtgaaaa gacggccgaa 1291381 atacgcgatt gatattgatt tgtataatga acagctgagc ccgcttcagc gccaggaaaa 1291441 agagcggtta gaaaaaaagt acagttaaac acggaaagag ctgacttcat tagtcagctc 1291501 tttttcttca actgatgcaa tatagcgcta agcggttcgt cttgcgggtt gcggtaaaaa 1291561 tcaaaaaatg ggcagccctg cttcttaatt cgatcgatga ccgtatcaat tgtaaacaga 1291621 gcgggtgtta aagatgattg cacctcatgc cagtagagcg gggctgcaac agtcccaagc 1291681 tcatttcctc tcgttgaata gggacagata atcgtttttc cttctgcatg ctgcaaataa 1291741 tcaagataca atttgcagtg tctgttttta atcaagcgtt cagtggtaaa gagctcggga 1291801 aatgcattgg tgcagtactc tgcgatcagc tgcgtaaatt ggcgtgtttc ttcatacgta 1291861 aatgcctcgg gagacaaggg aatataaagc tggatgcctt tgttgccgga cagcttcggg 1291921 tacgatgtga tgccaaagga atccaacagc cgcttcagtt catttgcggc ctgcacggcc 1291981 ataagaaagt catctcgcga aggcgggtct aaatcaatga caatctcagc cggacgcctg 1292041 cttttaatgg tttgaaaagg aacgtgaaac tccaaagcaa gctggttgca aagccatagc 1292101 aatgtagaca tatcctcaca gacaatatgt tcatggcttc catcatagaa agactgaaca 1292161 aaatccggcg catagtccgg cttgtttttt tggaaaaatg attcgctcct agatccatgc 1292221 ggatagcgga tgacggtgac agcccggttt ttcagaaatg ggagcaggta gtcactgact 1292281 tcaatcatat actgaataaa atcttctttt gtttttttat tcttttcaaa tatgatttta 1292341 tccaggcttg tgaactggag ctttgggtga accggtttgg agtgtcgtat gacttgcgca 1292401 tacgtgcatt cggtccagtc catttggaat tcgaaaccga taaacgatac ctctcttaat 1292461 gtgccttgga gaattgttaa gtattgaaca gctgcacaaa tcgaaggttc aagcgtaaat 1292521 tcgcctgagg gtgtttgatg tccgtgctgt tccataatct cgcgtatagc gcttttttcc 1292581 tcatcacgca ttccgtgcga gacagaggca atcggtgtca ttattccgtt ttttaacacc 1292641 gataccgtca gaaacccgtt gttagggttg aaccctgtta tgcaaacata agcttgttta 1292701 aagtttttat atttgagcca atcggacgac cgcttctttt caagccattt gctgtttgtt 1292761 ttcttcgcta caattccttc tccgtcatat tttattacca tctcccagag ttgatcaaaa 1292821 tgatcataac agggaatgga ttgaatggtt tcttttgcgt aaggatctgg agatgcagga 1292881 agctttgctg cggatatgag ttcacgcagc gattttttgc ggtccaaata cgaaagaagc 1292941 gttacatctt ctccgcttcg ctctaacaaa tcaaaggcga gaaagcagca cggccgcgcg 1293001 tttgccgatt cctgaatctt gtctggcctt ttcaaacgcc cccgcacttg aaggtgttca 1293061 aaatctgcac gacagggatt caccaaacat acgatttcac cgtcaagtgt cagcggaagc 1293121 tctttttcta ggtgctgaaa ggcagttttg gcgaattgtg tgatttcagg gaaggtgctg 1293181 ctgagctcca caccatttct gctggttaag gtcacacctg aagaatggat gcggagaata 1293241 cagcggtacc catcatattt tacttcgtaa cgccattctg ctccgattgg cggtgacgaa 1293301 gttaagaccg gctgcatggt aaacgccatg cgctatgatg tgccggaggc tttttttcta 1293361 gttgtttttt gttttttatc tccggctcct ttcggttcag cggcttgtgc aggtgcggca 1293421 gccggtgtct cccggttcgg ccttctggtt ctgtcgatgc tggcttgcag agcgcttacc 1293481 aggtcaatga catcttcacg aggtggcgct ttatcaggag tgacagccgt ttctttattt 1293541 tctagcttgt cgttgactct ttgcagcagc gcctgtcggt acgtgtcttc atatttctca 1293601 ggctcaaact tagcagtcag ttcatctatt aatgtgatag cagtttgcag ttccttatcg 1293661 tttacattcg attgatcagg tacacctggg acttgagcgg cgcttctgac ctcatcggga 1293721 taatggatag actccatgac gatacaattt tcataaacgc ggagaatcgc cagctgctgc 1293781 tttgacctga ttgtcatatt ggcgataccg atctttccgg ttgagcgcag cgcctcacgc 1293841 agcagggtat aggccttcgt cccattatcc ccggggccga caaagtagga gcggttaaaa 1293901 taaatcggat caatttcctg aagctgaaca aagtcaacaa tctcaactgc tttctcctca 1293961 tgctcctgtt ttaagctttt taaatcttcg tctgtcagca ctacatattt tccttttaca 1294021 tattcatatc ccttcacaat ttcatcagga ctaagagttt tttcgcaatt tgtgcaaact 1294081 ttctcgtatt tgattggtgc gtgatcctct ttatggaggc tgcgcagttt aatatcttta 1294141 tcttctgtgg ccgcatatag cttgatgggg atgtttacta atccgaagct gatcgatccc 1294201 ttccacattg tatgcatatc gataaacccc tttttttctt tagtgtgaag agaaggagta 1294261 cgattcatgt gtagtaactt atgggtgaaa aaaagccggc gctgttattg cgacggctgt 1294321 tcaataatga attgttcgaa ttgttccgga ggtattggcc tgctgaaaaa gaagccctgc 1294381 aaatggtcgc agcctttttc aaaaagaagc tgcttttgag ctgcattttc cacaccttcg 1294441 gcaatcacct gcaaagacag ctgatgcccc atggcaataa tagctccggt aatttgctct 1294501 gatttaggat gggtctgaat atcgtcaata aatgatttgt caatcttcag cctgtgaatc 1294561 gggaagtcct tcaaatagct aagagagctg tgaccagtac cgaaatcgtc aatactgatt 1294621 ctgattccta attctgttag ggatgacaaa acctttttgg agtgattgag attgtccatt 1294681 gtcatgcttt ccgtcacctc cacttcaaga agctgcggag gaagctggta cttattaagc 1294741 gtatccttga tgaggggaat cagatcttta gattgaaact gtctggcgga aatattaatg 1294801 gcgacagaaa gatcatagcc tttgtcatgc caaatccttg cctgcttgca tgcttcatct 1294861 ataatccact ttccgatatc aataataagt cccgtttctt ctgcaacacc gatgaattct 1294921 ccgggcggac gcagttgccc gtctggtgtc acaaggcgta tcagtgcttc tgctcctgtc 1294981 attttttgtt ttttcacact gaattgcggc tgataatgca agacaaatct atcgttttcg 1295041 attgcttctc tgagtaccat ctcttggtta agcttaacgg tttctttgtt gccgattgaa 1295101 aaagaatagt atctgtattt gcttttgttt cgttctttag ccgcatacat cgccatatca 1295161 gcctttttca tcaattcaag gccatccgtc ccgtcttttg gagatatcgc aatcccgata 1295221 ctgacagatg tgacaagggt gtgatcttga attttgaaag gttttttgaa tttttggata 1295281 atttttcttg ctaaaacatc tgcttcgcct gttcctgtat tggcgtctgt taatataata 1295341 ataaattcat caccgccaag acgggcgata aatccgttat cagggactac agatgacagg 1295401 cgtttagctg caaactgaag caattgatca ccgacattat gccctaatgc atcgttaatc 1295461 actttaaacc ggtttaagtc aagaaagaat acaacagtgt tataatgcaa ggaatgctcg 1295521 cgattcagca cctttgttag atgagagatg gcatgccttc tgttaggtaa gtctgtaagc 1295581 gaatcataat gagccattct atggatttct ttttctgctt tgtactgctt cgtcatgtct 1295641 ttacaaatga cataaatgct gtctagttcc tgattgacct caacaggtat aagcgtaata 1295701 tttaagtgaa actggccttt ttcagtgata agatcgctat cgctgttcat cgcttgttta 1295761 tcttttttaa cttgctcaaa aaggcgctta accttcagtg atgtgtaatt cctccagtca 1295821 tgcatgctga agccaaattt gctgatcatt tcctcaccag cgtgattgga agatattatg 1295881 tctccttcta atgataaaat aaaaattgca tcaatattgt ggacgattaa agactgaaat 1295941 cgctgttcgt tatcctttat gcgttcgctc tgtttaataa actttcgatc tgcatgggaa 1296001 ctgaataaca ataacgtttg gatacaaaaa ataattaaag taacaaaaat tgaccaatga 1296061 aacgtttgca cctccatatg gcttccgggc ggagccatgt ccttatggaa agttgccgca 1296121 agcatccctg tgtagtgcat gcccgaaatc ccaatgccca ttacaattga actgacgcct 1296181 ttatagaata taagatgctc agaatgtttt tttacggcca agtcaaagaa tatttttaac 1296241 gagacgaaag aggctgcaat cgcaatgata attgaaactg taaataaaat aggttcgtaa 1296301 ataatcatta cccgggaaat ggcagacatt ccgatatagt gcatagaagc aatagatgcg 1296361 ccaagcacaa ctgatccggt aagcagtctg taatatgtaa gaatgtgccg gctgacaaaa 1296421 tataatgaca caaatgatcc cgaaacagat gcgccaatgg ctgccattaa aggcatgaat 1296481 tcatattcca tcggcatttc catatggacg gccatcatcc ctacaaaatg cattgaccaa 1296541 ataccgaatc ccataataag tgagccgccg atcagccaaa ttttactttt taagcctgta 1296601 ttgatggtga ctttccttga aagttcaagg gaaatatacg aggcggtaca ggcaattaga 1296661 atagataaac atatgagagt cgtattatat gtaacgtgta tttccaaatg gagattcccc 1296721 ccgtatcgtg tgttccagtc ttgttgactc tctttattat cggctgctta accgcagagt 1296781 ttcagccttc aaaacgatag aaatacgagg gagatctatt tttagttcaa ctgaccgtga 1296841 aaaatgtgtt aaaatcatct tgatgttttc cgaaaagaga aaaatgtatg atacataaac 1296901 atgaaacaag ggagttggtg gctatcgaag agctggttat gtcatggatt gaagcattta 1296961 aaagcttatc ttattttgga atatttctag cgctcagcat tgagtttatt ccggccgaag 1297021 tcgtcttgcc gcttgcgggc tattgggtat ctaaaggcga tatgacactt gctggcgttg 1297081 ttttggcagg atcgcttgga ggagtggccg gtccgcttac gctgtattgg ataggccggt 1297141 acggaggaag gccgtttctt gaacgttttg ggaagtatct ctttattaaa cctgaagcgc 1297201 ttgataagtc agataatttt ttcaaaaaac atgggggctt tgtcgccttc agcggccgtt 1297261 tcttgcctgg tatcaggaca ttgatttcca taccgtgcgg aattgcaaaa atgaatgttt 1297321 gggtgttttc gctttataca ttcattgcta tgcttccgat tacatttgta tatgtttatc 1297381 tcggtgtgaa gctcggtgaa aattggaagg cagtcggctc tattcttgat caatatatgc 1297441 ttccgatcgg gatagcgatt ttggcgctgt tcctgctcta cttactgatg aaaaagagga 1297501 agaaacgcac gcactccgaa caattatctg tatttttgaa aaataaacgt tgacaaatca 1297561 ctgcgctgcg catattattg acgtataaaa tcatatttct tgaaatccca aaggggagta 1297621 gcgtccggaa tgtattccgg aaacaaagtc gtcatttcat ggattgtatc catcggcttt 1297681 gttggcatgc ctgaattcat gtctagcaag acctttgcct tatgtcggca aaggtctttt 1297741 ttgcatggtc cggccggcat aagatcggat gaagagaaag aaaacaactt ttttgggagg 1297801 gtatcattta tggatgcagc attattatta gagtatggtt gggttcttct cgtcttgatc 1297861 gggctggaag ggattttagc cgccgataac gcgctggtta tggcggtaat ggtaaaacat 1297921 ttgccggagg aaaaaagaaa aaaagcgtta ttttatggat tggcaggggc ttttgttctg 1297981 cgatttggct ctttatttgc aatttctttc ttggtcaacg tatggcaggt tcaagcgatt 1298041 ggcgcgatct atttgctgta tatctcagca agccacttat tgaaaagata tgtatttaag 1298101 aaagaagaca cacataaaga gacgaagcaa agcggttttt ggccgactgt tttaaaagtt 1298161 gaactggcag atatcgcgtt tgctgttgat tccatcttag cagcagtagc gctggcggtt 1298221 acacttcctg ggacatcact cccgaagatc ggcggacttg acggaggaca atttctcgtc 1298281 attttggccg gcggtatcat cggactggtg atcatgcggt ttgcggcttc catgtttgtg 1298341 aagttattaa aggaacgtcc aagcctagaa acagcagcct ttgtgattgt cggctgggtc 1298401 ggagtgaagc ttgctttata tacgcttgcc catcgcgaca tagcggttgt ttctgagcac 1298461 tttatccatt ctggaacatg gaagctgata ttctggggtg tcttagcagc aatcgcggtt 1298521 tgcggctggt ttatgtcagg tgggaaaaaa cagccggagg gtgcacaaaa cgaacaaaaa 1298581 aacagcaccc gtgaacgggc gtaatctgaa agactctgct taaaagcaga gtctttttgt 1298641 gtttgaagcg ttttcataag cgaaataaaa taacattttt ataacatctt tgttacaaaa 1298701 aacacgcata aaaccccctt aattctttag aaaggcacga aatcatgtat agaacgtcag 1298761 aatggtttgt cataattgag acattggaaa tcaatatttc tttttctcct ttgcgaatcc 1298821 ctatcaaatt agctatcatt aatgagtagt tatagggagg aactgaggtg aaaccagtgc 1298881 ttagcctttt gtttaaattg ggaaaaaaga agcaaacact tgaaaaagct gttgagagta 1298941 tacaaaaagg caataaagat ctgcaaaatg aattaataca gcaatataag ccatttatcg 1299001 caaagacggt ttcatccgtt tgtaaacgat atatagatga aaaagacgat gagttcagta 1299061 ttggactgat cgcgtttaat gaagctatag aaaaatattc acctgaaaaa ggaaattctc 1299121 tgctcgcatt tgctgagctt attataaaaa gaaaagtcat tgattacatt agaaaagaag 1299181 ccagaagcgc acaaaatata aatatcgatt tacaggaagg agacgatcag gagtcatcac 1299241 aaagcctgat tgaagccgag ctttccattg atgaataccg ccgtcagatt gaacaggagc 1299301 agaggcggga ggaaatcctc tattttcaaa agcagctcaa ggattatggt ttatcgttta 1299361 aagaactgct tgaaaattct ccaaaacaca cggatgcaag gcaaaacgcc ataaaggtgg 1299421 caatgacgct tgttgaacat gaagaattgg ccgctatcct gtatacaaag aagcagcttc 1299481 cggtcaaaca gcttgaacag cttgtctctg taagccgaaa aacgattgag agaaacagaa 1299541 aatatattat tgcgatgtgt attatcatta cgggtgatta tatttattta aaagattatc 1299601 ttaaaggggt gctgcactca tgagaagagg gattatagta gagaaaaata aaaaattcgt 1299661 cacgttgctg acccctgacg gacaattttt aaaagccaaa aatgatcgac acagctatga 1299721 aatcggagaa gaaatcatgc ttccgagtga aacacgcatg ggcagaaggg ccagcttttt 1299781 tgattttttt aaactgcgcc ctttcaaaat ggggattttt acgatgactg ctattatgct 1299841 ctttattttt atagttctcc ccgttttttc taataataag gcctatgcgt atatgacaat 1299901 cgatatcaat ccaagcgtcg aaatggcgtt aaacagcgat tatgaagtga ttgaactgac 1299961 gcctctaaac gatgagggac agaaagtcgt gaatgatata gatgattggg agaagactga 1300021 ttttaaaaag gtgattgacg atattataac cgactgcagt gaacacgggt atgtaaaaaa 1300081 atcgaaagaa atattgattt ccactgttta tgaaaacaca gaagacaata catataaaaa 1300141 ggctgtgaaa aaacagctga atgatgtgac tgaaaaatat aaaacgacat accgcatgga 1300201 atctctcgag tcagatatgc aaacgaggga aaaagcgaag aaagaaggcg tctcaacagg 1300261 cagctacatc aaatcaaatg aaaagaatga caataaagat ataaaagatg actccagcaa 1300321 accatccggg gaagaggatc aaaagagtga tgaaaatgag gatgaaaaca ccgatcaaac 1300381 tgacacccag gacagcaagc aaggagataa tgaacagctg aatgatgcgg attccggaga 1300441 ccagaaagaa gagaaagcgg atgaccagat tgatgatagt gacaaagata aaaaaataaa 1300501 ggaatcagat gaaaacacaa ataccgaaaa agatggggac catgagcaaa ccccaataca 1300561 agatcctcaa gataaaggaa atgaaaataa cggcgctgac aagggccaaa gccaatatca 1300621 cagggactgg aacaatggtg aacaaggcaa gaaccgttct tcgtccagaa gggataacgc 1300681 ttcagaccga cgtaatccaa acggctacag cagtgataat cattcagcta aaaatgaaga 1300741 ttcgccgagt gcccccggcg aataaagacc tgaatttatt tagttgtgcc atttaattgt 1300801 gattgtgctt gctgtaccag ccgctttgtc atttctccgc ctacagagcc gttagcgcgt 1300861 gcgactgtat cagaaccaag gttcacaccg aattcttgag ccacttcgag tttaaattgg 1300921 tctagtgcct gctccacccc tggaacaacg agtttatttc tgctcgccat ctttttcatc 1300981 tcctttttcg ataaagaaat tcttaacgcg tatttagttt gaaatatacg gggtttattt 1301041 atgctggcaa ttgttgtgga gaaaaataaa accccggcct ctgagccggg gtggcgcaga 1301101 ctatagaatg tctgctgtca ttttatgtgc ggttgcctga atatggaatg tcaaaatgga 1301161 gaggactgta atggcgataa tctgtctgat tttaagccat tggctgtcat tcagttcttc 1301221 aaaacggtga cggagacgct ctgtctcctg ttcggcgatc tcctgcagat ttgattcttt 1301281 catagaagga gtatcttggt gatggatggc atcaagcaca tatgcgcagc tttcataata 1301341 agcaatcggg ctgatgacat catcagatct gtctgagatt gtgttaaagg ccacttttaa 1301401 aatagcccgt atgtgttcaa agtcataaat ggattttaaa tcacgtacaa ttaaaagaat 1301461 aactgcctgt tcaattgagt attttttgcc cagctcaggg tgtccgatca gatctttgat 1301521 atcacgcttt acccagtttt gaatcgcggt tgactttaac gaagtcagct cgcataagtt 1301581 gccaagctct acgatttcat ttgtagacag accgtattct tttttctgtt tttttcgttc 1301641 gtatcttgta agaaattcag gaatttctag atgattggct gctttttctg ctgacatgtt 1301701 cgctgattgg acgagaatgt cgagcgggct atgttctcct tgtcctttta gggaatagag 1301761 cagccgcacc atatcggttc gagagagttt aaaaatgttc attgttcacc tctttaaaca 1301821 atttgacgcg gatataggtc tatgtataag ttcaaaattc aagcgtcagc aaattacatt 1301881 aacatcatac gtcgaattcc ttgcattttc aaatggatgt tttataattt aaatatacgg 1301941 gttcttttga acttaaaata acggaggttg ttatggcgaa aagaattttt ctgtttattc 1302001 taacgaatat tttggtgctt acaacaatcg ggatcgtttt gtctgtttta agctctgtta 1302061 caggagtcgg gacgtacttt acagctgatg gcggtatcga tccaatggcg cttcttgtgt 1302121 tcagtttagt cgttggattt gtcggttcct ttacgtctct tgcgatatcc agatggatgg 1302181 caaagacgat gatgggcgtc agagtgctga atccgaaaaa acactcgctc agctatgagg 1302241 aacagcaatt ggttgatcgt gttcacagat taagccgctc tgccggttta acgaaaatgc 1302301 cggaagtcgg gatttaccgt tcacctgaag taaacgcgtt tgcgactgga ccgtcaaaac 1302361 gccgttcact tgtcgcagta tcgtcagggc tgctggagca gatggatgac gcagcagttg 1302421 aaggtgtgct tgcccacgag gtcgcgcata tcacaaatgg tgatatggta acaatgacgc 1302481 ttttacaagg tatcgttaat acctttgtcg tctttttatc gcgtatcgcc gcttggatag 1302541 caagccgttt tgtcaaagaa gatctagcgc cgatcgttca ttttattgca atgattattt 1302601 ttcagattgt cttttcgata cttggcagcc tggttgtgtt tgcgtattca cgccatcgtg 1302661 aattccatgc tgacagggga ggagcggatc ttgccggcaa ggacaagatg attcatgcgc 1302721 tgcggacgct taaaagctat tcttcccgga ttttggaaga cgatcagaca gctgtccaaa 1302781 cgttaaagat taatggcaag aagcgctctt cacttttctc tactcatcct gatttagatg 1302841 agcgaatcag acggctggaa gctaaataat acaaacacat tgttcctctg agagaattct 1302901 cagaggtttt ttattttatc cattgactaa aatcataaaa aaataagcaa gttaagaaaa 1302961 tgtttcgtaa aagcctttaa aaatggacct aatatcttta gaataattac cgtacttaaa 1303021 aagagaggca gaaggatttt acatgagatt aaagtttgga aaattgatac aggccttgtc 1303081 accggcccag ctgatcgcat tatattattt tcttgcagtt actgtggccg ttatattgct 1303141 gagtttgccg gcggcccata aaccgggggc ggattggacg tttattgatg cgctttttac 1303201 agctgtcagt tcagtcagtg taacggggct gacagttgtt gatacagctg atacattcag 1303261 cacaataggg atttttatat tagcatttgt tctgcaattt ggcggaatcg gaattatgac 1303321 gctcggaacg ttcatttggc tgatcatggg aaaacgaatc gggctgaaag aacggaagct 1303381 gattatggtt gatcaaaacc aatcccagtt ttcaggaatt gtcaatctga tgaagcaggt 1303441 actgtttctg atcttgtgga ttgaattttt tggcgggctg atactcggca catatttctt 1303501 aacctactat gactcctatc aggaagccta tttacacgga ttttttgcca gtatcagtgc 1303561 aacgacaaac ggcggatttg atattaccgg taattcgatg attccatttc gccacgatta 1303621 ctttgtgcag tttattacaa tgcttttaat tatatttgga gcgattggat ttcccgtgct 1303681 tgttgaagta aaggatttcc tgttttcaaa gcatcggcgt tatccattta cgctttttac 1303741 aaagatcacg acgattacgt tcggctcact tgtcttgttt ggagccattg gcatctttgc 1303801 cctggaagca aaccatgcgt tcgcaggaaa atcatggcat gatattttgt ttttgtccct 1303861 gtttcaatca acggcaaccc gaagcggggg gctggcaaca atcgatatca gccaattatc 1303921 agattccaca ctctttttta tttgtgcgct gatgtttatt ggagcgtcgc caagctcagt 1303981 cgggggaggc ataaggacaa cgacttttgc tttgaacctt cttgcgctgt ttcattttgc 1304041 ccgcggcaat aaggccgtaa aggtattcaa acgggagctt caccctgctg acttgatgaa 1304101 gtcgcttgtt gtcacgatga tggcgatcct gctcgttttt ggcgcgacac tcattctgac 1304161 cattacagaa aaacattccc tgctggagct tttgtttgaa gtgtgctcgg cattcggtac 1304221 aaccggccta tcgcttggaa ttacggcaga tttgagcagt gttggaaaat gcgtcattat 1304281 gattgtcatg tttatcgggc gaatcggcat cttgaccttc ctgtatctga tcggaagaaa 1304341 ggaaattgaa gcgaattatc actatccgaa ggaaagagtg attatcggat aggcaaaaca 1304401 ccgcatattt tgcggtgttt tttgattacc aaaaaaaaga tgtgtgcctc ctgttcagtt 1304461 ggagaaccta actccgacag gtgcaattta cgctcctgca tcttaaaatg tctgaaaatt 1304521 ggcgaggagg attcgtatga agcgtaaagc tgaagtgaat gaagccatta aaaataacaa 1304581 tacacctacc gagagcatgg accccaattc atataagaca caatatcatg acgaccccaa 1304641 ttttagaggg gcaaaccgca attccaaaca gggccagcag ggaggcatgt aattgtgaag 1304701 aaaaaccgtc atagcagaga catgcaaaat cataaaaagc ctatgaataa aaaggtgctg 1304761 gaggaagaat tctcaagtga actcggggat tacaatgccg gaaagatcat cgaaacgctg 1304821 gaagtcacca agcctgaaaa gaaaaaagaa aaaaacaaaa aacaacaata aaaaagacct 1304881 cttaggcggc gtcccgctta agaggtgctt tttctatttt aaataagcat ttttgcccgt 1304941 tcctctgaca aattgcaata agcttgtcat cctcagctca atgaatggct gagcgactgt 1305001 cttaacaaag ttgctggaga ggactgatgt cagggctgct gttaaaagca agaggatcac 1305061 taagctttga tagtcagtaa gccaatcctc aagcccgacc tgccgtaatg tcttaataat 1305121 aaacccgtga agcagataca cgtaaaatgt ccgggttccc catttggtaa agaaataccg 1305181 tttttgcgga acgagcgcta aaaagctgaa ggttgcccca aaggcgagta cataccagcc 1305241 gattcgggat agtccgctta ccagggtaac gtctccaaat gaagaatacg gttttgaacc 1305301 aaacagaaaa gaatagtcaa aatcgatgcc ccagcagatg acgaatactg cggcaagcac 1305361 tccgagcgca atttgtttgc cgcgttttga tctcaataaa tcaaaatgat gtttatttaa 1305421 ataaaaaccg acaaggaaca tcggtaagaa tacgaatgtc cgtgacaagc tcagcgtgct 1305481 gctgacaaag tccagataac cgatcagcac ggcgattccg cagctgacaa acagcgccca 1305541 ctgctttgaa agctttgaaa aaggatatag gagcaggttc caaaagaata agcttacaag 1305601 aaaccataac gaccattgcg gatcaatcgg gttcacattt gccatgcttt catcttgcat 1305661 aatgtaataa aagacggaat aaataatttg gaaaatcaaa tacggaataa tcagcttgac 1305721 cgccagcttt tttacatatc ccgcccgttt aaagcctttc gcgaaataac cggatacaag 1305781 aataaatgca ggcatatgga atgtgtaaat gaacttgtag aggtagagca taaaatgatt 1305841 atcattaata aaggaacgaa ggatatgacc gaatacaaca aggaatatca ataaaaattt 1305901 tgcgttatcg aaataactgt cccgcgattt actcatagca tcaccttctc tttcatcagt 1305961 cactaagaga ttattccctg ctggtacata ttttaaaata aaagatgaaa aaggaatcta 1306021 aaaaaatgct gattgttagg tcgatgtaaa gtgacggtaa ggatcgtaga aaatgtcttc 1306081 gtaatgtaat gacgctgaaa ttttctgaaa tttatagggc aaatgaagga agttcccgca 1306141 ttttgtagaa atattgaggg ataggttttg aagaaggagt gtacatgcat ggaaactctt 1306201 ggtgtccaga caaactcgga gctgcgagag gaactgaatc gcctcaaaga agaaaacgcg 1306261 cgactgaaaa aggaattgaa tcagcatcaa gtgattgtca acaatacgct cgatgctatt 1306321 tttatttgtg ataacgaaat gcggattgtt caggcaaatg aagcaacaga aaggatgctt 1306381 caagttgact cggaagattt gaaaaagcgt tctgttttgg attttttgtt ttcaatccca 1306441 aaggatgaac tgaatctttc cgtaaagaag ttttttaaaa aaggctttct gtggaaggag 1306501 gttccgatca ggcttgattg cggggcaaca aaatacatag agtttctggc caaaagaggt 1306561 attggtgagg atttcttttt tgttgtcatg agggacatat cttctaagaa gattctggag 1306621 cgggaattct ctatgaatga acagcttttt aaggacttgt ttgacagagc agttgacgga 1306681 atcgtcctgt ttgataaaga tggcggtttt attgatgcaa atttgtcctt ttgtaaaagc 1306741 tttgaaatca atcataatga gctgtctcat ttatctttgt atgagttcat agacagcggc 1306801 tcacgaaaag atttcgacaa tatctggaag gcgctcaacc gcaagggaaa agcgaagggg 1306861 gagctgcctg tcaagcttcg ttcaggagtt caaaaactat ttgaattcac gattacatca 1306921 aacatcatca gcggttttta tatgtccatt atgagggata tcacagagaa gcggtctatg 1306981 gagctgcagc tctttaaaag tgaggagcgc ttcagagaaa tctttgaaaa tgcaatggac 1307041 gccatcatca tctggtcgaa tgacggaaga atcgtaaaag cgaatcaatc agcctgtaaa 1307101 atttttgagc tgccgatgaa tttgctgttg aaaagaaagc tgtgtgattt tctcgttgac 1307161 tcgcagcaga aatacagcat aacgaagagg aaatacgcaa aatacggaga gatcagagaa 1307221 gagctgctgt ttcaaatggg gaacggccaa ttcaaagagc ttgaatttac ttcaaaacgg 1307281 acaatccttg aaaatcagca tttgacgatc ttaagaaatg taagcgacag aaagcggatg 1307341 gaaaaggagc ttcgggaaag cgagctgaaa ttcagaaaag tgttcaacgg atcaatggac 1307401 ggcaatgtat tgttcgacaa tcaatacagg atcatcgacg ccaacccgtt agcaagccat 1307461 attttgggcc tgtcacatga agagatcaaa cagcacagcc tgttagatat tatttctgct 1307521 tatgaaatag aaaatttggc atcaccggca aggcagatta attttgatga aatggacaac 1307581 gaaattccat ttttgctgag cagcggtgat aacagaaaac tcgaattctc atttaaacgg 1307641 aatattattc aaaatatgaa cttggctatc tttaaagacg taacagagcg aaaagaattg 1307701 gaggagcgcc tgcgcaaatc agataccctt catgttgtcg gcgaactcgc agccggtatt 1307761 gctcatgaaa tcagaaatcc gatgactgct cttaaaggct tcattcagct tctgaaaggg 1307821 agtgtcgagg gagactacgc cctttacttc aacgtgatca cctcagaact aaagcgcatc 1307881 gaatccatca tcaccgaatt cttgatttta gccaagcccc aggccattat gtatgaggaa 1307941 aaacatgtta cccaaattat gagggacacg atagaccttc taaatgcgca agccaatctc 1308001 agcaatgtac aaatgcaact tgatttaatt gacgacattc ccccgattta ctgtgaaccg 1308061 aatcagctga aacaggtttt tatcaatata ttaaaaaacg ccatcgaagt gatgcctgac 1308121 ggcggaaata tttttgtaac gataaaggca ttggatcaag atcatgttct aatctcctta 1308181 aaagacgagg gaatcggaat gacagaagat aaattaaagc gacttggtga accgttttat 1308241 acgacaaagg aacggggaac tggacttggg cttatggtaa gctataaaat tattgaagaa 1308301 catcaaggcg agattatggt agaaagtgaa gaagggaagg gcaccgtttt ccatattacg 1308361 cttcctgtca gacagaatgc tgaagaaaga aggaatgatg aatgaactac tatacgacag 1308421 ccgaaacgcc gctcggtgaa cttatcattg ccgaagagga ggaccggatc actcgtctat 1308481 ttctcagtca ggaagattgg gtggattgga aagaaacggt tcagaatact gagcataagg 1308541 aaacacctaa tcttgcagaa gcgaaacaac agcttcaaga atatttcgca ggcgaaagga 1308601 agacattctc cctgccgctc agccaaaagg gcactccttt tcagcaaaaa gtgtggcaag 1308661 cgctggagag gattccatat ggcgaatccc gaagctatgc ggatattgcc gctgctgtcg 1308721 gcagtccgaa agcggtgcgc gctgtcgggc aggctaataa acgtaacgac ctgccgattt 1308781 ttgtcccgtg ccacagagtg atcggcaaaa acagtgcgtt aacaggatac gccggaagca 1308841 aaacggagat caaagcattt ttgctaaaca tcgagcgaat ctcctataaa gaaaaataaa 1308901 acatatggca cgttcccttt tttcacggcc gacatatcat tttattaagt taaaaaagtt 1308961 ggtctgatga aaaaggagga caaagcaatt gaagccgagc cgctctgaga aacttgccgt 1309021 ttttgccgaa ctgtttgtga aactgcatat cttatcaagc gctcaaaaag atgaaatcat 1309081 caatgttaac aaaaagaaac aaaaaaaccg ctgactcggc tccaaatgag caaagtccag 1309141 cggtttttta atgcaccttt tctcctttaa acagctgttc aatctcttct tcatagtttc 1309201 cggtcataat ccctttttct gtgatgattc ctgaaatgag atcatgaggt gtaatgtcga 1309261 aagcgggatt aaagacaggc acattggatg gagcggtccg aactccggaa atctgcctga 1309321 cttcctcggg atctcgttcc tctatcggga tatcagcgcc gcatttgacc tttgtatcaa 1309381 atgtagataa aggtgcggcg acaaaaaacg gaatatcaaa ggcgtttgct aaaatagcaa 1309441 gaccgtatgt gccgatttta tttgccgtat caccgttctt tgcaattcgg tcggctccga 1309501 cgataacagc ggaaatttgt ttttccttca tcgtatgggc ggccatgctg tctgtgatca 1309561 gagtgacatc aatgcccccc tgcatcagct cccaagcagt aaggcgtgaa ccttgcagga 1309621 caggccttgt ttcacaggca taaatgtgta atcccaaatc tttttgtttg gccaagtaaa 1309681 acggagctag cgccgttcca tagcggcttg tcgcgattga gccggcattg cagatcgtca 1309741 tgatcctgtc gccttttttg aaaagctgca gggcgttttg gccgatcaac cggcacgttt 1309801 cctcatcctc gacctgaatc tgaatggctt catggacaag gtttgttttt gcttcattta 1309861 cggaaatcgc gttttcgacc gaatgactca gtctctcaag cgcccatgac aaattaatgg 1309921 cggtaggccg tgagctgttt aaatattgtt tgatgtcttc cagtctgcgg cggaattccg 1309981 tgacattgtc tgtttcaatg tctttggcag caagcgccag tccgaaggca gctgtaatgc 1310041 cgatcgccgg agcgcccctt actttgagcg tgacaatcgc atcaaataca tcctctttcg 1310101 tcgtcagctc caaatattcc gtctcatcag gaagcttttg ctgatttaaa atggtaatag 1310161 ctgtttcttt ccattcaaca gaacgtggaa cagcaaatga atgggtcatg aatagatcat 1310221 tcctttacaa gtaacttaaa taattcaata acatctgtta tcgttttgaa ttccgaacgt 1310281 ttttcgataa aggctgtgcc ggtttcgagc gccaagcgtt ttctgccgat tcgtttatca 1310341 aacggcacga tcgtatccag gtcagctaca tgggcaaggc cgatcgtgcg tcgtatcagc 1310401 tcacagcccg caaatccgat tgcttcttca aaaatatggc tgagcgtatc agtgaggtaa 1310461 ccgtcgatgt tggcgtaaac atccagactg tccttctgcc aggcttcact aaacgtctct 1310521 tcaaacgttt cccagacctg gttgacatgt tcatataacg gctctctgtc agccccgtca 1310581 cggctgagtg cgttcaaaaa taagttggcg ataaattgcc ctacatcaaa gccgatcggt 1310641 ccgtaaaaag caaactcagg atcaatcacc tttgtttcgt gctcacttgc gaaaatgctt 1310701 cctgtatgca aatcaccatg aatcaacgtt tctgcagacg ttaaaaatga ctttttcagc 1310761 ttagcggctt cgattttaac gctgtcatta ttccaaagct tttcgacaaa aggacgaagc 1310821 tcttcttcaa aatcatttgt gtcatggtcg aagaaaggat ctgtaaaaac aagtctttcc 1310881 gtaatgtcgc atagctctgg atttgtaaac tgtttaacaa gctgtttttt caccttaggt 1310941 tcaagcgcgt aatctgatga gtagaaaagt gtttttccta aaaattcacc gatgtgctgc 1311001 gacagatgag gatagttttc accctcaatg agtccttttc ttgcgatctt gaggtgagag 1311061 agatcctcca tgacggtaac cgccatttcc gtatcagaat aaaacactct tggaaccagg 1311121 tgaggcacat gctcgccctg acggatgaga gcgctgcttt cgattcttgc acggtcgatt 1311181 gtcagcggcc agctttctcc caccactttt gcatacggaa ccgcctgttt aatgatcaat 1311241 gctctgtcat gttcttgatc ataaatatga aaaacgtaat ttaagttgcc gtctccgatc 1311301 tcctggcatg tcagcgtgct tttgcttgga aataggccaa gcttcaccgc caacgccaca 1311361 gcggagcttt catttaacgt ttcgtataaa ggtgtttttg tgactcccat catcataacc 1311421 tccaattatg taattaatta atatgtggcc gtaaaaaagc ctccttctca gagagaagga 1311481 ggcttaacat ctatgtccgc ctctcttatc tctcagatca gatctgaatg gaattagcac 1311541 cgtgccttaa gagaccagcg tctcggcgcg aaaaaaatgc gccccatttc acaatggaat 1311601 tacggtcggt tgcttttggg gtcaaaaggc caaatccctc gcccaactct cgataagaga 1311661 atatattcac ttgtttgaca attctaattt atcagttgat gaacatggta acaggtaatt 1311721 tagttagttg tcaatatatt ttttaatata aatcttttct gatatcatcg aaaacaggaa 1311781 tgctctcccg aacttctgcg ctttcttgaa ggtcgatttc cgctcggact atgccttctt 1311841 cccggccgcc ttcagcaagt acacgtcccc atggatcaat aatcaggcta tgtcctgcaa 1311901 attcattatc cggatttgaa ccggtacaat tgcaggctgc gacaaagcat tggttttcaa 1311961 tggcccgcgc aataagcagg cttttccaat gatcaaggcg gggaagaggc cattccgcag 1312021 aaataaacag cacgttggcg ccttttgtcg tatgttttct gatccattcc ggaaaacgga 1312081 tatcgtaaca gatcaatcca gagcttttga cgccgtcaag ctcaaagtat ccgtcttcgg 1312141 aaccggctga taaatacaga tgctcatcca tcagctgaaa aagatgggct tttctgtact 1312201 ctttaatgat ttgcccttcc ttatccgcga tgtacattgt attataaaca tcagaattct 1312261 tcctgacagc gaccgatccg gcgacaatat gaacaccatg tttttttgcc gttttcttca 1312321 gccagctctg agcggagcgg ccgtcttcgt cagcgagttc atcaagattg gccagatcat 1312381 atccggtcgt ccataattca ggcagaacaa gaacatcagc atgtttgctt tctttttcga 1312441 tgaaaaattc agcctttttt atattttccg aaggttttcc gtatgaaata tcaaattgaa 1312501 gacaagatat cgtccatttc atctttttaa caccccaaat ttttctttac ttttttcatt 1312561 taaccatata tgatgatgga ctatcatttc aagatttttt tagaaggtga gaatagatga 1312621 aatttgaaca gtctcatgta ttgaaggaat tgcctaaaca attcttcgct tctctggtgc 1312681 agaaagtgaa ccgaaagctt gcagaaggac atgacgttat caatctggga cagggaaatc 1312741 cagatcagcc gactcctgag catattgttg aggagatgaa acgagctgtc gctgatcctg 1312801 agaatcataa atattcgtct tttcgcggct cataccgtct gaagtcagcg gctgctgcat 1312861 tttacaaaag agaatacggc attgatctgg atccggaaac cgaagtcgct gtattattcg 1312921 gcggaaaagc cggtctagtc gagctcccgc aatgcttgtt gaatcccggt gatacgattt 1312981 tagttcccga tccgggttat cctgattact ggtcgggtgt cacacttgca aaagcaaaga 1313041 tggaaatgat gccgctcgta aaggacagag cgtttctccc tgattacagc agcataaccg 1313101 ctgaaataag ggaacaggcg aaattgatgt atttgaatta tccgaataat ccgactggag 1313161 ctgttgctac ttccgagttc tttgaagata ccgtgcgttt tgcggctgaa aacggaatct 1313221 gcgtcgttca cgattttgct tacggcgctg taggatttga cggctgcaag cctttaagct 1313281 ttttgcagac tgaaggtgcg aaggatatcg gaattgaaat ttacacgctg tcaaaaacgt 1313341 ataatatggc aggatggcgg gttggctttg ccgtcggaaa cgcttcggtc attgaagcga 1313401 tcaatcttta tcaagaccat atgtttgtca gtcttttcag agcgactcag gaggctgcag 1313461 cagaggcact gttagccgat cagacgtgtg tggcagagca aaatgccagg tatgagagca 1313521 ggagaaacgc ttggatcacg gcatgccggg aaatcggctg ggatgtaaca gctcccgcag 1313581 gttctttttt tgcatggctg cctgtgcctg aaggctatac ttctgagcag ttctcagatc 1313641 ttttgctgga aaaagcgaat gtggcagttg cggctggaaa cggcttcggt gaatatggcg 1313701 agggctacgt cagagtcgga cttttaacaa gtgaagaaag acttaaggaa gccgcttatc 1313761 gaattggcaa actgaacctg tttacccaaa aaagcattga caagacctta taacgatggg 1313821 ataattcaaa ataatttata aaatctatat tttcttatca agagcaggca gagggacgag 1313881 cccgatgaag cccggcaacc gacttataaa gcacggtgct aattcttgca gctagcggct 1313941 gagagataag attcggacga gaaacgaaac ctctttagac gcgattgcag tttgaagagg 1314001 ttttttgata tggatgaaaa tgaaaggagc tctggcatga gtgagttatt agcgacatat 1314061 ctcctgaccg aaccgggagc cgatacagag aagaaagcag aacaaatcgc aacaggattg 1314121 acagtaggct cctggactga tctgcccctt gtaaaacagg agcaaatgca aaagcacaag 1314181 gggcgggtga taaaagttga ggagagagag ggaactgctg catcagaaaa acaagcggtc 1314241 atcacaattg cctatcctga aatcaatttc tctcaggata ttccggcttt gctgacaaca 1314301 gtgtttggca agctgtccct ggacggaaaa atcaaattaa tcgatcttca cttctctgaa 1314361 gcatttaagc gtgcactgcc gggaccgaag tttggcgtat acggcatccg gaagctgctg 1314421 ggagagtttg agagaccgct gttaatgagc atatttaaag gcgtaatcgg aagggacctg 1314481 agtgatatta aagaacagct ccggcagcag gcgcttggcg gagttgactt gattaaagac 1314541 gatgaaattt tctttgagac tggtctagcg ccttttgaaa caagaattgc agaaggaaag 1314601 caaatattga aagaaacgta tgaacaaacc ggacataaaa cgctgtatgc ggtgaatttg 1314661 accggacgta cggctgatct gaaagacaaa gcgagacgcg ccgccgaatt gggagcggat 1314721 gcgcttttgt ttaatgtctt cgcttacggc ttggacgtta tgcaaggcct tgcagaagat 1314781 cctgaaatcc cagttccgat tatggcgcat ccagcagtga gcggagcgtt tacgtcttct 1314841 ccgttttacg gtttttctca cgctctttta ctcggaaaat taaaccgata ttgcggtgct 1314901 gacttcagcc tctttccgtc tccatatggt tcggttgcgc ttccaagagc agatgcactg 1314961 gcgattcatg aagaatgtgt gagagaggat gcttttaacc aaacatttgc tgttccgtca 1315021 gcaggcattc atcccggcat ggttccgcta ttaatgcgtg atttcggcat agaccacatt 1315081 attaacgccg gaggaggcgt acatggacat ccgaacggtg cccaaggcgg ggggcgagcg 1315141 ttcagagcta ttattgatgc ggtcctagag gcccagccga ttgatgaaaa agccgaacaa 1315201 tgcaaggatc ttaagcttgc gctagataaa tggggaaagg ctgaagccgt atgacgactc 1315261 gaaaaccttt tattatttgt gattttgacg gaacaatcac gatgaacgac aacattataa 1315321 atatcatgaa aacatttgct cccccagagt ggatggcatt aaaagacggc gtactttcca 1315381 aaacgctgtc aatcaaggaa ggtgtcgggc ggatgttcgg ccttctgccc agcagtttaa 1315441 aagaagagat tacaagtttt gtattggaag atgcaaaaat cagggaaggc tttcgggaat 1315501 ttgtagcatt tatcaatgag cacgagattc cgttttatgt cataagcggt ggaatggact 1315561 tttttgtata tcctttgctt gaaggcattg tggagaaaga ccgcatttat tgcaaccatg 1315621 cttcatttga caatgactat atccatattg actggcctca ttcctgcaag ggcacatgca 1315681 gcaatcaatg cgggtgctgt aagccgtcgg tcatccatga actttctgaa ccgaaccaat 1315741 atatcatcat gatcggtgat tcggttacag atgtggaggc agcaaagctg tctgacctat 1315801 gctttgcaag ggattattta ttaaacgaat gccgggagca aaacctcaat catcttccgt 1315861 atcaagattt ttatgagatc agaaaggaaa ttgagaatgt aaaggaggta caggaatggc 1315921 tgcaaaacaa gaacgctggc gagagctcgc tgaagtaaaa cgggaattgg cagagagaga 1315981 ttggtttccg gcgactagcg gcaatctgtc aattaaggtt acagatgagc ctttaacatt 1316041 tctcgtcact gcaagcggaa aagataaacg caaagagacg gttgaagatt ttctgctggt 1316101 cgatcaaaac ggagagcctg ctgaaagcgg gcattctctg aaaccgtcag cagaaacgct 1316161 tttgcataca catttgtaca ataaaaccaa tgccggatgc tgcctgcatg tccatacggt 1316221 aaacaataat gtgatttcag agttatacgg agaccaaaag aaaatcacat tcaaaggcca 1316281 ggaaattata aaagcactcg gcttgtggga agagaacgca gaagtgaccg ttccgattat 1316341 agaaaatccg gcacatatcc cgacgctagc ggcactgttt gcggaagaga tttcagaaga 1316401 ttcaggagct gttctgatcc gaaatcatgg tattacggct tgggggaaaa cagcatttga 1316461 ggcaaaaaga gtgcttgaag cgtatgaatt tttgttcagc taccatttga aattgaaaac 1316521 actcgagcat cagctggtta aataaaagga ggaattgaaa tggctacaat tcgaattcat 1316581 gatgaggcaa atacaacgat tgaaaatcaa gaggaagtgg caagctttct ggacagtcaa 1316641 gaggttattt atgagcaatg ggatatcacg aggcttccgg aacatctctc agagaaatat 1316701 gacctgacag aagaagaaaa acagcaaatt cttgatacct tcgaaactga aattaaagat 1316761 atctcaaccc gccgcggcta taaagcacag gatgttattt cattgtcaga cagcaatccg 1316821 aaacttgatg aactgcttga aaactttaaa agagagcatc accatacaga cgatgaggtt 1316881 cgttttattg taagcggaca cggtattttt gtcattcaag gccaggacgg cacgtttttt 1316941 gatgtccgtt taaaccctgg agatttaatc tccgtgcctg agaatatccg ccattacttc 1317001 acgcttcagg aggaccgcaa agttgtcgcg gtgagaattt ttgtcacaac tgaaggctgg 1317061 gttcctattt atgaaaaaga cagcgtgaat caataagcgt gagatagccc cgttcatcga 1317121 acggggcttt ttatatttat tgcaaacgcc acttttcata ttgtgacagt tcttttttaa 1317181 tcagtgtcca aatcaaacct aaaacagctg catcgtcaat gaatccaaga ccgaggatta 1317241 cgtctggaat gatatcgagc ggcatgacga tatacaggat tgcggcagtt aacagcaaaa 1317301 gtgttttaac ctgtgaacga gggtagtcgc catttcgcca atcgcgaagc atctgaaaaa 1317361 aagtagtgat gtgctggata catttttttc ggtttttcct ctttaaaatc gcttttccgc 1317421 ctgccgctcc gagcattatt gctttctttt tcttcattgg gcatacctcc tgcctggcgg 1317481 cgtgtttaag atattcttca cctgggtatt gttcttctaa tcctatcaat atatctatta 1317541 tacctgaaaa attaacttat ttaatgaaaa tatgtttaca aataaagtat aatctgtaat 1317601 aatgcacaat aacccaatca aacttgtttc ctatttctta gcggcgaggg gtgaagtgaa 1317661 tgggcggttc ttctgaacaa gaaagattgt tggtgtctat tgatgaaaaa agaaagttaa 1317721 tgatagatgc cgctagaaag cagggattta cagggcatga cacgatcagg cacagtcagg 1317781 agctggattg tttaataaat gaatatcatc agcttatgca agaaaacgaa cattcccaag 1317841 ggattcaagg ccttgtaaag aaattaggct tgtggccccg cagagatgtt atgccagcat 1317901 atgatgcaaa taaatagcgg cctatcagat gcatatataa agagagagct tttcggaagc 1317961 gctctttttt tctggaaaaa attcatatga aagagggaac taatgaagga actggcgatt 1318021 ctcattaccg aaatggtcaa tcaatttcat gatgctttta tttccttatg cggaatattt 1318081 ggcattcatt taactgacaa agaaatgcat ttttgggtga tcggcatttt tggcatattc 1318141 tttttcggcg tcactcacgc tgtgtttaca tggctttcta aatggagtat gacagccttg 1318201 tcctttatct ataccgttac agtcatcatt gtcatcgtat ttgcgattga gattcagcaa 1318261 aaggtgacgg ggagagggaa tatggagttt ttagatgcca cggaaggtat aaagggtttt 1318321 ttagtatttt ttatgttttt tttgcttttg aaaatgctgt tgcgtttcat caaaatcctt 1318381 ttttctggaa gaccagcaag caaatcgaat ggcaatgccc gatcacgaag ataaaaaacc 1318441 ctcctgacat ggtcaggggg gctatgatgc ggatacgggg agggtgatcg tcacctctgt 1318501 gcctcttcgc acttcacttt caatatgaat agagcctccg tacatcagca cgatccgttt 1318561 acaaacaaca aggccgagac cggttccttt ttctttagaa gtaacaaagg gaaggaagat 1318621 gtgatccagc atttcctgag aaatcccttc accgttatcc acaactttga ttatggcttt 1318681 tttatctaaa gctcctaggg agatcgtcag tttgcctcct tcaggcattg actcgaggcc 1318741 attttttgct acatttaaaa tcacttgttt aatatgatct tttgtacatt ttacgagtaa 1318801 gggctgctcg gttagatact gtaattcgac ttcaacattg tatagattgc cctcagaata 1318861 aatgatcggc ataatttctc cgataatgtc ctgaagtgag ttcagctccc atttttcagc 1318921 tgtcggcttg ccgagaacga gaaactcact cactatttga ttgatgcgct ttatctcctg 1318981 ttcgataatg gagaagtaaa gctgatcttc ctcaccttta tatttctttt gcaacagctg 1319041 aataaagccg cttatcccgg tgagggggtt acggatttca tgggctgtgc tggcagcaag 1319101 cgtcccgatc agctctaatt tttgcgcctc gttttctgag cgctccagct gggtctgccg 1319161 cttcagcaaa taatacagca cgagaataaa aaggatattc agcagaacaa taatacatga 1319221 aagcggaagc acaaggcttt tcgacagttc ttctattgtg accgggttcg gatagacttt 1319281 catattccag ctgatatcat ccagatatcc gctgacaggt ttctgatcct ctgcatgaga 1319341 ggcttgtccg ctcgcaaaaa tcattttccc gtcttggttc acaacttcaa tataaacatc 1319401 agggcttagt aagttaatga gatttttcaa ataatcaatt tgaatagctg cgacaagata 1319461 atctgtcaca ttacgttttg agtccaaaac aggcacacaa attgtgaaaa ttggctgacc 1319521 agtaattctg ctcgaataac tatctgaaat gactgtcttt ttagtttcct ttgcttttat 1319581 aaaaaaagat ctgtcggcca ggtttacttt cgtttttaat tcggttgtgc ttgcggtgac 1319641 gtctcctttg gcattgagaa aatagagacc ggaaaatctc ggctctgaat caaaggtctt 1319701 ttccaaaatt gattgcattt tctttatatc aaccggtctg tcgatggcga tggacaagga 1319761 ggtcattctc gccattgttt ctccgattaa ataattgatt ttgttgcggt gaaggtttag 1319821 caggacactt gcttcttgtt tatgttctgc agctattgta tctttttctt tttcatatac 1319881 gaaaaagctg atgacgattg ccggaatcac gaccagtatg atataaagtt tgactctccc 1319941 gcaggcgcct tttagtattt tcaatttgca tcgctccaac atacacctga ttagaggtat 1320001 tatatcattg tttcttcttc tttaataaga aaaaataacc aaaaaaatta gaaaaagatg 1320061 ttggcaagct tacattttaa aaaagaagag aaatattgga aagattttta ttgacatttt 1320121 ggtctttgtt tattaatgtt tctctgtaac ggtttctaaa aggatgattg agacatgaca 1320181 gaaaaatcac tgaagttatt tatcgtgctg tcgcgcgcgt atcggtctat taacgatcat 1320241 atgaataagc atattcataa gcatgggctg aatccgactg aatttgctgt gctagagctt 1320301 ttgtaccata aaggcgatca gccgctgcag cagataggag ataaaattct cttggctagc 1320361 gggagcatca catacgttgt agataagctg gagcaaaaag aacttctcat tcggaaagcg 1320421 tctcctacag acagacgagt gacatttgcg caaattactg aaaaaggcat cggtcttttg 1320481 aacgatattt tccctgatca cgctgctgaa attgatgaaa tgatcagcgt attaagcgaa 1320541 gaagaggtag agatgtgcac cgaaatgtta aaaagagtag gattaaacgc aaaacagttt 1320601 cataataagt aaaaaaagga agcctgatat gtcacaaggc ttcctttttt gctatttttc 1320661 atttgtttcc gctgcgcctc tcggcaaaat gagaacttca acccgccggt ttttgcttcg 1320721 gccttccgca gttttattgg aagccaccgg tttatactcg ccataaccct tggcgctgaa 1320781 cacttttgca tcgagcttgg ggttttcaat caggagcccc ataaagttta ccgctctcat 1320841 gacgcttaaa tgccagtttg attggaattc agaattttta attggcatat tatcagtatg 1320901 tccgctgata atgatatttc ttggcgggtt aatcacaaga agatttgaaa tctcttttgc 1320961 aagcggcaca tcttccttac ggatggtcgc ttttccagaa tcgaagaaga tgctgtcttt 1321021 aatcgtaatc agaaggcctt cactagtcat cttcgtctcc agctgatgtt ccagcttttt 1321081 atctttgatg aacttttcca cctggctctt cacattttca agttcttctt gatcagctgc 1321141 tttttctttt tctttcttgt ttttctcttt ctcttctttt tcctttttca cttcatcgat 1321201 gccgtctgac tcgttttcag gaggagtgac actggagtag tccagtacac cggttccgcc 1321261 tgtaaaaact tcattaaatg attttgagag catttgaaac ttagctgcgt caatcgagct 1321321 gctcgcgtac agcacaataa acaatgccag gagaagagta aggatgtcgg cgtaaggaac 1321381 gagccatgat tcatcaacgt gctcgtcctc atgcttcttc ttcttttttc tcgccatttt 1321441 gcgcctctcc ttgttctgca aatttcaagc ggtccttcgc aggaagatac attaaaagct 1321501 tttgttcgat gactttcggt gcttgtcctt ctaaaacgga taaaacacct tcaatcatga 1321561 cctcacgcag ttttacttcc tgttttgatt ttcgttttaa tttatttgcg aaaggatgcc 1321621 ataacacata ccctgtaaag ataccgagaa gtgtggcaac aaaggcagca ctgatggcgt 1321681 gtccaagctc atctgtgtta tccatatgag agagagcggc aatcagcccg attacagcgc 1321741 cgagtactcc aagtgtcgga gcgtacgttc ctgcttgtgt aaaaatagcg gctcctgctt 1321801 ggtgcctgtc ctccattgct tcgacttcct ctgtcataat atctcttata aattccgcgc 1321861 tttgcccgtc aacagccatg ctgagcccgt ttttcaagaa agcatcatct acatcctcaa 1321921 tgcttgcttc taaagcaagc agaccttcgc ggcgtgcaag ctgagcccat tcagagaaca 1321981 taggaatgag ttcctctatt gtgagctgtt tattttcctt aaataacact cgaaacagcg 1322041 taggcacttt tttaatttct tttgttggga acgcaataac gactgctgag attgtcccgg 1322101 cgataataat taaaatggca gcggggtttg caagggcgct gaaactgacg cctttcagaa 1322161 ccatcccgac gctcaatgcc acaaaagcaa gaataatacc gattaacgaa gttttatcca 1322221 tagttttcac caaatccttt tttactagct tgtctatggt taatatcggt tttggtgccc 1322281 ggaactttag ggacattgtg aatttgttca tgaaatattc aaggaagagg catagaaggg 1322341 agaaataaac aaaaacgggc tctccaaaat tgaaaagccc gggggtctac tgaaattagc 1322401 agcttgcttg caagctgtcc ttcagatggt attcatataa tagtagaaat acatattcac 1322461 tgtatataaa catgttccat ccctccttaa aaaagtgtaa aggatgaagg gaagtagcgc 1322521 ttcaggagaa gggacggtaa tttctaagtc aagagtatga aagtataaaa aaaagcggct 1322581 tcctaaaagg aaaccgctga ttgttatttt gctcgcactt tgattttatc atcttctaaa 1322641 atcacgtgaa aacttgtgat ctcgccatta tcaagcagca gatcggtcat ttcatcctca 1322701 acccattctt ggatggttct tctaagcgga cgtgcaccga atgaagggtg gtagcccagc 1322761 tcagcgattt tttctttcgc ttcatctgtc acattcaagc taatgccccg ttccgccaat 1322821 gtttcttcaa gttctccaag aagaaggctg acgattttga caagatgttc tttttccaat 1322881 gagcggaact caataatgct gtcaaaacgg ttgaggaact caggtttaaa gaacatgctc 1322941 agtgaatcaa ttaatgtttg ttcttcgatg acactgtcat ctgattggaa accgactttc 1323001 gtttgtttct caccagcacc cgcattactt gtcatgatga tcacagtgtc tttgaagctt 1323061 acagttctgc cttggctgtc tgtcagacgg ccatcttcca taatttgcag gaacatatgc 1323121 tgaacgtctg ggtgtgcttt ttcaatctca tccagcaaca caatgctgta aggattgcgg 1323181 cgcaccttct cagttaattg tccagcttcc tcatggccga catatccagg cggtgaaccg 1323241 ataattttag atacggcgtg tttctccatg tattcgctca tatcgagtcg gataatagcg 1323301 tcttttgtgc cgaataattc atctgccagt gttttagaaa gctctgtttt ccctacgccg 1323361 gtaggaccga cgaagaggaa ggagccgact ggtctgtttt tggattttaa tccggcgcgg 1323421 cttcgtctta ccgcttttgc cactttttga acagcggctt cttgtccgat cacgcgttca 1323481 tgaagttttg cttcgagttc tttcattttc gtttgttcgt ctgcctgcag tttgccgaca 1323541 gggatgcctg ttttttgttc aacaatttcc tgaatgtgct cagcttccac agtgacagcg 1323601 gtatgagcgg aggagctgtt cagttttttc tccaatgcga gttcttcatc acggagtttt 1323661 gccgccagtt cgtaattttc ttcttccagg gcttttgttt tttcggcttc aattgcagtt 1323721 aagcgttcag cggcatcctc atcattcagt tcatcaatta acaggttggc ttttgaacct 1323781 gcttcatcta ataaatcaat tgctttatcc ggcaggtgtc tgtcctgaat gtagcgggat 1323841 gataaagtga cacatgcttt gattgcttca tcactgaatg ttacgccatg gtacgcctcg 1323901 tatttgtctt taatcccttg cagaatgagg atagcctgtt caattgaagg ctcctgcacc 1323961 atgacaggct gaaaacgtct ttccagcgcg gcatcttttt cgatttgacg atattctttc 1324021 agtgttgtcg cgccaatgac ttgcagttcg cctctggcta gggccggttt gagaatgttg 1324081 ccggcgtcca ttgatccttc tgcagagcct gcgccgacga gaaggtgaat ttcatcaatg 1324141 aacagaatga cattttttcg ttccttcagc tcagtgatca gctgtttcat tctctcctca 1324201 aattggcctc tgatccctgt gtttgcaaca agagatgcaa catcaagcaa gtatagctct 1324261 ttgtttttta gtttgtttgg aacatcacct tcagcaattt ttaaagcgag cccttcagcg 1324321 atggcagttt tccctacacc cggctcacca ataagaaccg gattgttttt gtttcggcgg 1324381 tttagaattt cgatcactcg cgccacttca tcatcacggc cgatgacggg atcaatgaga 1324441 ccggcttttg caccgtttgt aatattttga gccagctcat caagcaaccc ttttttttcg 1324501 ctttgttttg ctgcgctctg ttctttcggc tggaatgcct gttcaaacgg aaatccgaaa 1324561 gattgaggac ccatactcat tgaaggttta cgggtcagtt cgttatagca agtttcacaa 1324621 agaaccatct gtttatgaac ggaatttatt tgcatgttaa ggcgaatcgt cgcctcgttt 1324681 tgatgacaat gttgacaacg catttgccaa aacctcctta ataatttgat catctttgac 1324741 caatgaaagt gaataaaaag gtctattggg tttgaccttc tttgactatt agtatacggc 1324801 aaacttaacg gcattcaaac caatatgctc aaagcagact gaatatttga ctatctttga 1324861 ccaattgatt tttaaaaaag gccggtttgt ttgaccaact ttgattaata gtatactctg 1324921 actatctttg actttcaagt cttatgcaca aaaatttttg atttgttaca aagtaaaaca 1324981 tgttttcttc gtcttttcaa ggaacttgtc tcataggtta taaaaaggca tatatggaca 1325041 aaactgcggt tcgttcggag ggaagaaatg gaacaatcaa aagggtctgc aagtcagctt 1325101 gcttttgtgt atgtcggcac agtagtcgga gctggatttg cgactgggag ggaaattgtt 1325161 gagttttttc tgaagttcgg ctggttcggt tttttcggca ttctcgtcag cggcggaatg 1325221 tttacgttac tgggggccaa gctgatgatc atttcaaagc gaatcaatgc caagtcatat 1325281 caagaaatga acatattttt gttcggggcg acggctgggc ggattatcaa tgtatttatg 1325341 ctgtttgttc tccttggagt tacatctgtt atgctttcag gggcaggggc gctttttgag 1325401 gaacagctgg ggatgtccgc tcagattggg atgctcatta caatcggtct gagtttaatt 1325461 gtgatgacta gaggagtaaa aggcattttc ggtgtcaatg tgtttgttgt tcctctttta 1325521 atcatctttt caatgattgt ggtggccgac tcttttatat tcagcgaatc acgaaacgca 1325581 gctcagtggg tctggccgca tcgctgggat tggctgttat cagcagtttc ttacggggct 1325641 ttaaatttat cgcttgccca agctgttttg gttccgctgg cgaatgaaat gtcatcggag 1325701 aaagtgataa aaaaaggcgc tttaatcgga ggcacgatgc tgacgattgt gctgtccgcg 1325761 agttttctgt ctttgtcgac tcttccggat gtatttttgt atgatatacc gatggcgcaa 1325821 gtggtttatc tctttgcacg atctgtccat ttgatttatt tactcattat tttcggagaa 1325881 gtgttcacat cagttatcgg taatctatat ggattagaaa aacaagtgca aagctttctt 1325941 ccagtgaaaa gcaaatatat ctttgcagcc attatgatca cggcttatat tacgagccaa 1326001 atagggtacg gcaggcttat ttcaacgatt tatcccttgt ttggctatgt gagcctggcc 1326061 ttcataggcg ctttgctttg caaaaaagct cctcggcggc gcagtttata aatatatata 1326121 atgaaacgaa ccgtcactat agagcgataa ttgatctagg aaccggggac tgactttttt 1326181 attgtcaaga aaaacatcat tatggtaaga tagcagaagt gaaaaaattg aagaaaatcc 1326241 gtgcgatatg cgggagaggt tctagctaca ccctctataa aaaactaagg acgagctgta 1326301 tccttggata cggccttttt tatgtttttc tagagcacct tccgaaaaaa ggtgtttttt 1326361 tgcgtgaatt agctgtagcg atgtctctcg ccggcgtttt tattgcggag aaggagagga 1326421 atcatgaaaa aagaaaaagc aattgtcgta tttagcggcg gtcaagacag cacaacatgc 1326481 ttactgtggg ccttaaaaga attcgaagaa gtcgaaacgg tgacttttca ttataatcag 1326541 cgacattcgc aggaagttga agtggcaaaa tccattgcgg aaaagcttgg tgtgaaaaat 1326601 catttgcttg atatgtcact tttaaatcag cttgcaccga atgccctgac tagaaatgat 1326661 attgagatag aagtaaaaga cggcgaactg ccatccacat tcgttccagg ccgcaatttg 1326721 gtattcttat cctttgcgtc tatcctggct taccaaattg gcgcgcgcca cattattaca 1326781 ggagtttgcg agacagactt cagtggttat cctgactgcc gtgacgaatt cgtgaaatct 1326841 tgcaatgtca cggtaaatct ggcaatggag aagccgtttg tgatccacac gcctctcatg 1326901 tggctcaata aggcggaaac gtggaagctt gcagatgagc ttggcgcgct ggattttgtg 1326961 aaaaacaaca cgctgacatg ctataacggc atcatcgcag acggctgcgg cgaatgtccg 1327021 gcatgtcacc ttcgttcaaa aggttatgaa gaatatatgg tgatgaaagg agagcgtgca 1327081 taaattgtta tctcaaattt atccgcaggc ccagcatcct tattcgtttg aactgaataa 1327141 ggacatgcat atctcagccg ctcattttat ccctcgggaa agtgcgggag cgtgcagcag 1327201 ggttcacggg catacgtata ccgtaaatat aaccgttgcc ggcgacgaac ttgacgattc 1327261 aggctttctt gtcaatttca gcgtactcaa aaaactggtg cacggaaact atgatcacac 1327321 gctattaaat gatcatgaag atttttctca ggacgaccgg tattcgctgc cgacaactga 1327381 agtcgtggcg aaaacgattt atgacaacgt acaggcttat ttagacactt tggagaataa 1327441 gccgacctgt gtacaggtgt ttgtccgtga aacaccgaca agctactgtg tctaccgtcc 1327501 gaaaaagggt ggtttgaatg gctaaaggaa ttcctgtatt agaaattttc ggcccgacga 1327561 ttcaaggaga aggcatggtg atcggacaga aaacgatgtt cgtccggaca gccggctgcg 1327621 attattcctg cagctggtgt gactccgctt tcacttggga cgggtctgct aaaaaagata 1327681 ttcgctggat gacggcggag gagatttttg cggagcttaa ggacattggg ggagatgcgt 1327741 tttctcatgt gacgatctca ggcggcaacc cggctctgtt aaaacagctg gatgctttta 1327801 ttgaactgct gaaggaaaat aacatccgtg cagcgcttga aactcaaggg accgtttatc 1327861 aggattggtt tacgctgatt gatgacctga caatttctcc aaaaccgcca agctcaaaaa 1327921 tggtaacgaa ctttcaaaag cttgaccaca ttttaacttc acttcaagag aatgatagac 1327981 agcatgctgt cagcttgaag gttgtcatct ttaatgatga agatctggaa tttgccaaaa 1328041 ctgtgcacaa gcggtatccg ggaatcccgt tttatttaca agtcggaaat gatgacgtgc 1328101 atacgacaga tgatcagtca ctgattgcac atttgcttgg aaaatatgaa gcgcttgttg 1328161 ataaggtagc tgtcgatgcg gagctgaatc tcgtcagagt gctcccgcag ctgcacaccc 1328221 tgttatgggg caacaaacgc ggagtataat agaaaggaag atgaacatga cgacaagaaa 1328281 agaatcagaa ttagaaggtg taacattgct aggcaatcaa ggtacaaatt atttgttcga 1328341 atatgcaccg gacgtgctgg aatccttccc taataaacat gtaaaccgtg attactttgt 1328401 aaaattcaat tgcccggaat tcacatcttt atgtcctaaa acaggccagc ctgactttgc 1328461 gacaatctac atcagctaca ttcctgatga aaaaatggtt gaaagcaaat cattaaagct 1328521 gtatctattc agcttcagaa accatggtga cttccacgag gactgcatga atatcatcat 1328581 gaacgacttg attgaattaa tggacccgcg ctacattgaa gtatggggca aattcacgcc 1328641 aagaggcgga atttccattg atccgtacac aaactacgga aagcctggca cgaagtatga 1328701 gaaaatggcc gaataccgta tgatgaacca tgatttgtat ccggagacaa ttgataatcg 1328761 ttaattattc cgttgtgtga tacggagtgt aaaaggaagt ggagtcacag taaaatccga 1328821 acattcagcg ttaattttca gcggaaatgt gacctggtca cagcgaagtg tgacccgcac 1328881 taagctcaat aaaagtggga aaagtcacac ctgaaaatgg ctctactcat gggaattgta 1328941 ttaaaaagtg tgacctgagg tgcaacctga actgtgactt ttatgcagtg aaaaattgat 1329001 agtacagaag cagattaagg cgtacaattt gtacgtcttt tcttttttat ccgaaagaaa 1329061 aaatgcctat ctagagatca taggcattaa atattattat caatatcttc atttattttt 1329121 tggctaagtt tctgaacctt ctctttaaca tttgaaacag ctcttttttg aatttcatca 1329181 attctcctga atatagtcga tgacacttct tattagaact tcactttcaa aattgaatat 1329241 ctcatttatt tctgactgtt cttcatctgt taggtgatgg tattgaagtt gtttagcatt 1329301 tacttcagca gctacatcaa tcctaactta gttgttctgg ttgtacaatt tcatattcac 1329361 cttctgcata ctcttgctcc gcataatagc ctccccattg acagagctcc tgcaagatag 1329421 gtttaagaga ttctccaagt tcagtggatg aatattcaac cttcggcggt acttgattat 1329481 acatctttct gctcacaagt ccactggctt caagctctct aagtgtttga atcagcattt 1329541 tctgagttat atttgggata atgcgcttta attcactcgt tctctttggt ccattcatta 1329601 aaaagtataa tacaaggcct ttccattttc cgccaataac ttcctttgtc acttcaaacc 1329661 cacagctaaa ttttttcatg tctaaagctc tccattccac atttattact ttttagttac 1329721 tatatcacaa aaaagtgggt acttccgata atgtgcttac tgaaggatac tatatcttgt 1329781 aagttgttct tcaagtactt aaaggtacta gacataaaat aaaattaatt ctaaaggagt 1329841 gttaagtatg ggtaaatttg aaggtaaaat agcgcttgta acgggtggaa caagtgggat 1329901 tggtcttgct acagcacaaa aatttgtaaa cgaaggtgca tatgtttata ttacgggacg 1329961 tagacaaaac gaacttgata aagctgttaa ccaaattggc aagaacgtaa ccggtgttca 1330021 aggtgatatt tctaagcttg aagacttaga caaactatat gacattataa agcaggaaaa 1330081 aggtaagttg gacattcttt ttgctaatgc aggcatcggc aacttccttc cattaggtga 1330141 aattactgaa gagcaggttg atagaacgtt cgacattaac gttaaaggaa ccatctttac 1330201 tgttcaaaaa gcgttatcac tattcccgga caaagtaggt tctattattg taacgggctc 1330261 tactgctgga tcaattggca acccagcgtt tagtgtatat ggagcatcta aagcagcatt 1330321 aagagcacta gttcgcaact ggattcttga cctaaaaggt actgaaatcc gtgtaaatgt 1330381 ggttagtcca ggaggtattc ttacacctgc ctacgatgag ctttttggtg atgcacttga 1330441 agaggtactg gaaaatagca gaaatactgt tccagctgga aaagttggga cacctgaaga 1330501 agtagcaaac gctgtatctt tccttgcttc agacgaaagc agttacttga cgggtgttga 1330561 attgttcgta gatggcgggc tagcacaggt ataatttcac tgcgcagaga ttacaaatag 1330621 tccccaaaaa aggttaatgg ggatttactt gaagaagtcg tataaaaaag tcgttttcct 1330681 taaaggacag ggaattcgac ttttttatat ttgaatttga ttaacgttgt aaattcgcat 1330741 tttcctgggg ctactactaa atgacctgta aaaaagatta cactgtgaat aaatgtactt 1330801 aaagtaacgg gggctcttga cttttaataa aaaataatat ccctgtcctt gtattctaat 1330861 acttttaaaa atatttaaag gaatccttat gtcctgaata accacatagg aaaatatgtt 1330921 gtaggttgct ttcttttttt gtggggcatc ccacacaagc tatctcgtga tctcacacct 1330981 gaacgttttt tatagactag taccgcgaca agttatatta catatacata ccaataaagt 1331041 agacattaaa aagtgaaaga gaggatggaa atgtgtgaaa attcttttcc ttgagagtca 1331101 tcccatgtgg ctctatggtt taccgaatgg gtttagggaa gcaggacata ccgtaatgat 1331161 ttccggtcct gtaagtcggg aaaatataac tgaaatgata gacgaattta aaccagattt 1331221 aatagtatct atgggatgga caccagagca ttcaagggaa aagcaggcct ggattcgcaa 1331281 cgctactaaa aaggtgaata tccctctcgt ttattgggca actgaagacc cgctgcacac 1331341 tcaaaacttt actatcccgt taattaaaaa gatgaaaccg gattttgttt tcacggtcac 1331401 gccttctctg tgtaaaactt atgaaagcat ggggattaaa gcagctcact tagactttgc 1331461 atttcacgaa agtatacatc accagattaa accattagcg aaatacagtt gtgatatagc 1331521 agtggtggct aatgcttacc ctaattttct tgaagaacat ccggaagtgt tccgttcgtc 1331581 ctctttaaaa acgcttattc gtcctcttat acggaagggt attcgcattg atttttgggg 1331641 gagaaactgg gaaaaaatga gtaaatatat aggaagagaa attccccgca attggatcca 1331701 tggatacctt gattatactg aagcatataa agtttacagt tcagcaaaaa tcattatcgg 1331761 tttgcaaaac tgtgaaagcc aacttacaca acgcacctat gagattcttg gttccggggg 1331821 gtttttattg acatcggata caccagcagt tcgaggtaaa ttcaaacctg gccgcgatct 1331881 catcgtttct tcctccccaa aagaaacatt ggaaaaggtt aaatactatt taaatcatga 1331941 tagcgagaga aaaaagattc agataaacgg taaaaaggct gtaaagaatg attcctatcg 1332001 gcatagagcc gagagaatgc ttgaggtgct aaaaagcaga ggaatcataa gaaacttagg 1332061 ggaaaccatt cattatgtag atgttctcaa agaaaaatac gtgatccatc atgttactcc 1332121 cggtgaaaca ttatcaataa ttgccagtaa gtataatgtt tccctgcagc aactcatgga 1332181 gcttaatcat ttcaaatcag atcaaatata tgctggacaa atcattaaga ttagagagaa 1332241 actgtttaga aatattaata acaaattatt ctaaaggaga gtaatatgaa tgaaggggaa 1332301 aatacctaaa ataagaaatc aagcgaataa agtaaaaaga acgcctcgtt atatggaatt 1332361 tcccgtgaca tacgaagtat atcatgtgga atccggcgat acattatgga cgattgccaa 1332421 atcctttgaa attccggtac aacaacttat gaatcttaat aagctttctt cagatagaat 1332481 ttatcctgga caaattataa agataagaga aagataatct ttgaggtttc ggaagcgaat 1332541 caaattgaaa tgacaatcct cattttttta tttgtgggga acttgatatt tttggggatg 1332601 aaggggttat gagatgtttc aaatgagcta ttactattct ggattaggat gggactttat 1332661 tcaacacgtt gatcaaacga acggagtatt aaatgttgtg tctcctgatt ttttctatat 1332721 cagaaaagat ggatcattac ttctccgttc agctaatccc gatgtgatta aagctcttca 1332781 tagaagaaaa ttaaaagtag ttccttttct aagcaatcat tgggatcagg atttgggacg 1332841 atttgcatta atgaaccgag ttcttttagc taaacaaatt tctcatgcaa tagaagaact 1332901 ggatttggat ggagttaata tcgatataga aaaccttaca gaaaaagatc ggaatctatt 1332961 tacagatttt attagattag taaggaaaag tattcctaga cataaagaag tatcagttgc 1333021 agtggcggca aatccttttg gctggacgaa gggctggcac ggatcatatg attacgagta 1333081 tttagctaaa tatgcagatt atcttatggt tatggcctat gatgaaagcc gccttgctgg 1333141 gcctactgca agtgtaggat gggtggaaaa gtccattcaa tatgttctga cccaaaaaat 1333201 ctctcctcaa aaactagttt taggattgcc attctatggc cgctgctgga tggaaggcca 1333261 atctgcctct caagccattc ccctttacct tgttgttagt aaaaaggcat agcgggacaa 1333321 ttatttttga caccaagagt caatctccaa aagctatttt tactgtcaat cacgataaaa 1333381 aggggccgtt gccttcggga acatatacat tatggtttga aaatgaacag tcactcagag 1333441 caaaaataaa actcgctcaa aaatataatc tgaaaggtct tggcagctgg agtcttggac 1333501 aagaagatgc gtcagtctgg aatacagtgt ttaaaaatat ataatgattt atagttcaga 1333561 acaaaattcg aagataattg caatgaatct ctaaatggac atactgaaag gagtttatta 1333621 cgagtgcggg taaaacagtg agggcattcc ataggccctt ctcccaaaat gttctacacg 1333681 aggcattaca ttgggcttga aatacacatt caaacttatg ttatagtacg cattttacgg 1333741 atgtgttgaa tttattctgc ttccatgatt taatcataca catgctactt gatagcaggg 1333801 ttatcgcatt tcattcagaa ttgttcagga tcgatatgga agcgcacgac taactagaac 1333861 tttaaaagca tacactcata tacttcctga atggatgctg gtttatctaa aaaacatgat 1333921 gagaattgat tgtacgcatg gtgaagcatg acttgttgat aatcgaccat atggtttctc 1333981 cttagaaatg agggggtttt tacataaaaa agacgagcga atccgggggg aattccactc 1334041 gccgctttct aatgaaaaga cgggatgctg gatggcagct cgtctgtttt attataattt 1334101 aacgaacgta tgtttgtaaa ggtgtctttt cgaatgaatt ggttcatata accgttaaga 1334161 acagattcat tgtaaacatt cgctaaggta tgctaagatg catggactat aaaggagtga 1334221 tatgaagtga agacattgcg gttaaacaat gtaacgttag aaatggctgc atatcaagag 1334281 gagagcgagc cgaagcgaaa aattgcattt accttaaacg ttacgagtga gacttaccat 1334341 gatatcgctg tcctgttgta tgaaaaaacg tttaatgtcg aggttccgga acgcgatctt 1334401 gccttccggg gggaaatgac aaattattca acatcattga ccaacctgta cgaaccaggg 1334461 gccgtcagcg agttctatat agaaataacg gaaatagaca aaaacgccga ttcatgatcg 1334521 gtgtttttta tgtaaaaaag ctgccggccg gcagcttttg agaaagcgaa tttcatatgt 1334581 aaggtgttaa attgtccgtc ttgcagtttt ttgaataaat gtggaaataa ggaggtttta 1334641 ataggagtct ctgatgatct tataattttt atgattaaca actgtcaatg aatctaactc 1334701 aagatcccga tagttatcca tgatcgtcac atcaacgata acagaattct catttacttt 1334761 ttcaacaaca ccggttaatc cgtttttaaa ttcaatgaca ttcccaacct tagcgatttt 1334821 cacaagcttc ctctccttta aacataataa tgccttttga aagtattttg cagtattttc 1334881 attgagaagt aaagcgataa ggagttttat ctcccttatg aattgttctg tcgctataaa 1334941 gatgatatat tgattttcgt caatagaaag aaaagggggg aatttttgtt gcgtcccgaa 1335001 gaaataacag aaatgattga acagctgcgc accggcgcca taaacgaact gagagtccag 1335061 aaagagcatt ttcttgattt cagggccgtg ttatctaaac aagatgattt taaacatttc 1335121 cgaggaattg cccagcaagg cggagatgtt atctttcaat acttagaaca gccaagaagc 1335181 tgaaggtttc tcatacgtga gaagcctttt tatcatatat gacagaacac aagcctttta 1335241 ttacagctgt ctgtaacagg tgtaaataaa atgtaaagta ccaaagatgg ataaacatgt 1335301 tttaatttaa caatatttat agaatttcag actgtttttt tgccattaag cagtgagtca 1335361 tcctctttat tccatcctga tacctccttg ggagagttgg aaaatctttt tccgtgaaaa 1335421 tgaatggatc tcttgttaag gttatgaagt gttttttgga gcactttaag gaggaaactg 1335481 tatgacaacg aaattcactg ctctggctgt ttttcttctt tgtttcatgc ctgcagccaa 1335541 aattgagcat acacaagctt cactactgag cgcaaagaag acaaaacatg aagaagcgaa 1335601 atggcttaca catatagatc gaaatacgaa tgaatctttc ccttcactgt ctgctgataa 1335661 agacaagaaa ataaaaccga ttaagctatc agcacacact gaaaagaaag agaaagataa 1335721 accggacaaa acaaatgatg agaaagaaac atatacacag tctgaaaaag agttgctgtc 1335781 ccgtctcgtt cacgcagagg ccaaaggaga atcatataaa ggcaaggtcg ctgtagcaag 1335841 cgttgtactg aacaggacgg agaaaaaagg ttttcctgat acgataagag gagttattta 1335901 tcagaaaaac gcctttgaac cggtcgcaaa cgggagcatt aaccaaaagc ctgataaaga 1335961 atcgattgaa gctgccgaag aagcgctgtc ctcaaaaaat agagaaacag atgccatatt 1336021 cttttataat ccgaaaacag cgtcagataa ttggattcgt tcaagaaaaa tcgtagaaaa 1336081 aatcggcaga cacgtttttg ccgtctaagc atagaagaga caatttgtct cagctgtgct 1336141 ttttttcata taaagagtaa aaataaaata atttttgaac ttgtctcata tgatgttggt 1336201 agtacaagag acaaggagag acatcatgaa tcgatttgtg aaagggatca ttcttttatc 1336261 cattgccgcc tttttcgctg aatgccttga atttgtcgtc aatatgattt tggcgcggga 1336321 gcttggcgag catgggatgg ggctttacat gagtattttg cccacgatct ttttaattat 1336381 tgtcatcgcg agcctggaac tgccgatatc catttctaaa ttcattgccg agtcaaatcc 1336441 taagcttcat gaaagcatgc tgaggcacgc tttcagaatg acagccattt ttactgcttt 1336501 ttctactgcc gccgctagta ttgcgcttcc gtttattccg gtatttgata cataccaccc 1336561 gtttattaaa gggattgtca tcggcttaat tcctgttgtc gcctttactt caatcgccag 1336621 gggctacttt atgggtgtgc agaaaatggg gaagatcgca attgccaatg tgctgaaaaa 1336681 aatcatccag ctcttgtgct tattcctctt ttttcaatgg tactcatttg aattggacat 1336741 ggctgtgctg atttccttgt ttgttctagt cgtgagtgat gtggtcgtgc ttgtttattt 1336801 atattcacaa tttatcatgg caaggcgggc gttatccggc cagcagcaca ttcatttgcg 1336861 cggaaaggat gtaaggaaaa gactgcttgc tgtttcaatt cctacaacag gactgcgtat 1336921 ttttcatgcg gttgtcaatg caattgaacc ctttttagta aaaggagctc ttttggctgc 1336981 gggcgttgcc gggacagcgg cgatcgatca atacggaatg ctggcaggag tggctgtgac 1337041 gatagggtcg ttccctgctt ttattgccca ttcgttaatg gtcgtcatga taccgagtat 1337101 ttcggaagct tatgcacttt ctcagtatga catcgtgtta aaaaggctga agcagtcgat 1337161 tttcattaca ttaggttacg gtatacctgc cgtctgggtc atgttccagt ttgcgggacc 1337221 tctcacgcat ttgttttttc actctcctga agcgcagtat tacttgcagc tgttgtggcc 1337281 ttactttctc tttcatctgt ttgtcatgcc gctgcaggcg tgcttaatcg ggatgggttt 1337341 tgtgaaagag gctttttatc acaatgtatg gagccatatc gttgcgctaa gtatgatgta 1337401 tgtactggga tcaatggaga atctgcaaat gctcgggatt atccttggaa tgaacactgg 1337461 catgattctt ttgacgagcc tgcactatgc cacgatctgc aaagcattga aggtatctgt 1337521 atttcttacg ggagggacca gaacgccgcg aattgaagga tgataaagga acagcagggg 1337581 caagctaatt gaaaagcatg aaaggaagat tccatgttga cgaagcgctt gcttactata 1337641 tacattatgt tattagggtt gattgcatgg tttccaggtg cggcacaagc tgaggaaaaa 1337701 cagcctgctg ttcccgctgt ttttcttatg aaaacgatag aaggggagga catctcgatt 1337761 ccgaataaag ggcaaaaaac aattctccat ttttggacgt catggtgccc gccctgcaaa 1337821 aaggagcttc cacagtttca atcgttttat gatgcccatc catccgacag tgtaaagctg 1337881 gtaacggtga atttagtgaa ttcggaacaa aatcagcaag tcgttgaaga ctttattaaa 1337941 gcaaacaagc tgacgtttcc gattgtcctt gactcaaaag gggaattgat gaaggagtat 1338001 catatcatca cgatcccaac atcatttttg ctgaatgaaa agggagaaat tgaaaaaaca 1338061 aaaattggcc cgatgacagc ggaacaactg aaggaatgga cggaagaata gctgagagca 1338121 tagactctca gcttttttca tatagagaag aagtgaataa acattaatga taattattat 1338181 caaaaagaaa ttaaaataat tataattgaa attctcttcg tgcgtgctat aataaaggaa 1338241 gacatcaaga aataactgac gataaagctg ccttttgggc agcgattttg tttttataag 1338301 agaaatgaag atgatttacg ttctcaatta gagaggagaa ttcgatatga atgaacaagt 1338361 tatcgttcaa cgcgacccgc atgagccatt gaaaacagac aagagggaaa aaaactgggc 1338421 acagcacgcg gagcttattg cagcacttgt atcaggcgct cttattttgg caggctggct 1338481 cttatccgga tatcaggtat tatccataat acttttcttg ctggcttttg tgatcggcgg 1338541 atttgctaaa gcgaaggaag gaatcgaaga aacactcgaa tccaaaacgc tgaatgtaga 1338601 acttttaatg attttcgctg ccattggttc cgccttgatc ggatactggg cagagggtgc 1338661 tattttaata tttatttttt ccttaagcgg agctttagaa acatacacga tgaataaaag 1338721 cagcagagat ttaacgtctt taatgcagct tgagcctgaa gaagcgacat tgatggtcaa 1338781 tggtgaaacc aaaagagttc cggtttcaga cttgcaggcc ggtgatatga ttgtgatcaa 1338841 acctggagaa cgcgtagcgg cagacggtat cattgaatcg ggctcgacaa gtcttgacga 1338901 gtcggcttta acaggtgaat caatgcctgt agaaaaaaac acaggcgaca ctgtattcac 1338961 aggaacggtg aatcgcaatg gctccttgac agtccgtgtc acgaaagcaa atgaagattc 1339021 gttattcaga aaaattatca aactggttga atcagcgcaa aatagtgttt cacccgcgca 1339081 ggctttcatc gaacgatttg aaaatgctta tgtgaaaggt gtgctaattg cggtggcgct 1339141 ccttttattc gtcccgcact ttgcgctggg ctggagctgg agtgaaacct tctaccgcgc 1339201 aatggtgttt atggttgtcg cgtcaccttg tgcgcttgtc gcctctatta tgccggcggc 1339261 gctgtccctg atttcaaatg gcgcccgcaa cggtatgctt gtgaaaggaa gcgtctttct 1339321 tgaacagctg ggctcagtgc aaatgatcgc ctttgataaa accggaactg taacaaaagg 1339381 ccagcctgcc gtagagacga tcagaatagc agaaggattc agtgaagcgg aagttcttga 1339441 ggctgtctat gccatcgaaa cgcaatcaag ccatccgctc gcccaagcca taacggcgta 1339501 cgctgaaagc cgcggcgtga atcagtccgg ctacatatct atagaagaaa cctcagggtt 1339561 tggcgttatg gcagaagtgt cgggtgcgaa atggaaggtc ggtaaagcag gttttatcgg 1339621 cgaggaaatg gcagcacaat ttatgaaaca aacagcatca gatgtcattc aaagcggtca 1339681 tacaattgta tttgtgaaaa aggatgatca aatagcaggc tgtatcgcac tgaaggacca 1339741 aatcaggcct gaagcaaaag aggtcatgga agaactgaac cgacttggga ttaaaacggc 1339801 catgctgaca ggagatcacg aagacacggc tcaagcgatt gccaaggaag ccggcatgac 1339861 aactgtcgtg gcagaatgcc tgcctgacca aaaagtgaat gaaatcaaac ggttaaaaga 1339921 agaattcgga acgattgcaa tggtgggtga cggaatcaat gatgcgccgg cactcaaagc 1339981 agcggatgtc ggcattgcga tgggcggcgg aacagatgta gcacttgaga ccgctgatat 1340041 ggtcctcatg aaaaacgatt tgaaaaagct cgtaaacatg tgccgcttgt ctcggaaaat 1340101 gaacaggatc atcaaacaaa atatcgtgtt ttctctagct gtaatctgcc tgctgatttg 1340161 tgcaaacttt ttgcaggcga tggaattgcc atttggcgtg attggtcatg agggcagcac 1340221 gattttagtc atactaaacg gtttaagact cctaaaataa aaccagcagc ctaatcaggc 1340281 tgctggcttt ttatgtatca agctttccct tcatttttgt ctttatcaga tcttttcata 1340341 actaggatga gagcgagggt gcagcaaagg aaacccgctg cacagcctat gatagagctg 1340401 taataataaa agcccaccat cttcatcccg ataaaaggag cggaaattcc caaaaccgtt 1340461 aagagcataa ctgcttttcg tctgaaaaaa ttcatcagca aacggaacaa cccccctgcg 1340521 attgaacgtt actgtcagta tacaggaaga ggagcaggaa ataaaatgca ttagaaaatg 1340581 aaggcgtcgt gaaaggcaaa caccggtaaa acctgttaca atggaagaca gaacaatgca 1340641 ttgcaaatgg cagggaggaa caagaagtga atagaataca acgcgtctct tcatggctga 1340701 aggaagcggg gcatactgcc gcatttattc atacgaaaga aaatgttttt tacttaaccg 1340761 gtttttacac agagccgcat gaaagattaa tggggttatt tatttttcaa gaagaggagc 1340821 ctttctttgt ttgtccagga atggaagcag gacaggcccg caacgcaggc tggaatcatg 1340881 aaatcattgg ctatgcggat cacgaaaatc cgtgggagct gatagagaag gctttgaaaa 1340941 agcgaaatat cagcatacat atgcttgcgg tagaaaagga ttcaatctcg ctgtcacgtg 1341001 cagaacagct gaagcatgcg acgggcgggg ctcaatttgt ttcagcagaa gaaacactca 1341061 atcaatttcg cctgattaaa gatgacaatg agattcgttt gctgaaagag gcggcaaagc 1341121 ttgcagatta cggtgttgaa gtcggcacag ccgctttgcg tgaaggcatc agtgaagtgg 1341181 aagtgctcgc tcaaattgag tatgagctga agaaaaaagg aattcagggc atgtctttct 1341241 ctacaatggt tttattcgga gaaaaatctg gccagcctca tggaaatcct ggtacagcca 1341301 cgttgaagaa aggtgatttt gttttatttg atctcggtgt tattcttgat ggctattgct 1341361 ctgatattac aagaacgttt gcatacaaaa ccatcaatcc gaagcaggag gccatttacg 1341421 agactgtgct tcaagcggaa aaagccgcga ttgaggcaag caaacccggt gtgagaatcg 1341481 gagatctgga tttaactgcc cgcggaatca ttgaaaaagc gggatatggt gattattttc 1341541 ctcaccggct tgggcatgga ctcggaattt cagtccatga gtatccatca atgagccagg 1341601 ccaacgatac actgctgcag gaaggcatgg tctacacgat cgaaccgggg atttatgtgc 1341661 cagagatcgg cggcgtacgc attgaggatg acgttcacgt aacaaaggac ggagcagttg 1341721 ctctgaccca atatccaaag gatttgatca tactgtaata gaaataaaaa aggactttgt 1341781 tctcgacatc gtcctttttt atctgcatta aataaaaaaa tcatcaaatg ttcgaaaggg 1341841 tttaatttca tgtttttggt tgagaggttt tacagcaaga cagctgccac cgagaacagt 1341901 gagacataac ccaattaaaa tgaagaaacc catgtgatct tctcctttca gctaaaaaca 1341961 caaaaagata tctggtacgt ccatatcata ttgtatgaaa cgcattccag atcaagggga 1342021 tttagaaaga agggaatcta tggctaatat taaagacatt gcagagaaag ccggtgtctc 1342081 tgttacaacg gtttcccgag tcataaacaa tcatccatac gtcagtgaag acaaacgaaa 1342141 aagagtgttt gaggcaatgg aatcattgga gtacacgaga aatattcacg ctgtacattt 1342201 gtcgaaagga ttttcaaaca tgattggtgt tgtcttgccg acggttaatc tgccatattt 1342261 tgcagagctg attgcaggaa tagccgacgc agccgcggaa tccggggttc acctctcttt 1342321 attccaaaca aactatgaag tacaaaaaga aatctttgcg ctgtcccaat taaagcagcg 1342381 ccaggttgac ggcctgattt tttgctcaaa ggcgcttgct gatgagaaac tcatggaatg 1342441 ggagggcccg attttgcttt gccagaattc agataatgcc cgcttcccaa ccatcagcat 1342501 tcctcaccaa gaagcatttc ggaacggctt ggactattta attgccaaag ggcacaaaaa 1342561 aatagccatc tgtttggcaa gaaaaaaagg catgaacagc cattttcgaa tcaaagccta 1342621 caaagaggca ttggaagaga tcggcgaggc atttcgtgaa gactgggtaa ttgagaaagc 1342681 gattacaatc aatgatggga aggcgctttt tcataaatgg aatacgtgga aggaaaagcc 1342741 gacggctatt tttgttgcca atgaccaagt ctcagcaggg ctttttcttg aagcaaagaa 1342801 ccagcgggtg tcagtaccgg atgagcttgc aatcttaagc gttgataacc acgaaatcag 1342861 ccaagcgctt ggaatcacaa cgatcgatat tcagacaagg gaaatgggaa agcaggcatt 1342921 tgccatattg gaaaaaagaa ttcaaggaca gccgattgaa aggaaagttc tggattaccg 1342981 tctcatcgaa agatcgactg tttagtgaat gcattgaaaa aaggtttgac gtgcattctg 1343041 ttcgttatgt acgatatgag gtattgaatg acaaaggagc tgaggatcgt gaatgggtcc 1343101 ttcacagtga aaaaggtact gaataataac gtattaattg cttctcatca taaatacagc 1343161 gaagtcgttt taatcggaaa aggtattggt ttcggaaaaa aacaagatga tgtcattgaa 1343221 gataaaggct acgataaaat gttcatttta aaagacgaga aggaacaaaa gcagtttaaa 1343281 aagctccttg actatgttga tgaaaagctc gttgatattt caaacgatgt catctatcac 1343341 ataagcaata ggacgaatca ctcattaaat gaacatattc acattgcgtt gacagaccat 1343401 atcgcatttg cgatcaaaag gcagcagcag ggatttgata tgaaaaatcc atttctaatg 1343461 gagactcagt cactatatcc tgaggagtac caaattgcca aagaagtcat agatatgatc 1343521 aatgaaaaag cgggactctg ccttccggaa ggggagattg gttttatcgc tctgcatatc 1343581 cattcagcgt tgacaaaccg tccgctgtcc gaggtcaatc agcactctca gctcatggcg 1343641 cagcttgtcg aggtgattga agactcattt caaatgaaag taaataagga aagtgtcaac 1343701 tatttgcggc tgatcaggca tatcagattt acaatagaaa gaattaaaaa agaagaaccg 1343761 actaaagaac cagaaaaatt aatgttgtta ttgaaaaatg aatatccgct atgctacaat 1343821 acagcttgga aattgattaa aatcttgcag caaacattga agaaaccagt tcatgaggcg 1343881 gaagcggttt atctgacgct tcatctgtac cgattaacca ataaaatttc ataaattcag 1343941 tttatcctta taacgtgtta ctgattcgat caggcatgag tgattgaggg aaaaaaacgg 1344001 gaagttcatt ctcgttcttt tgcgcaccca attttgctca tgcctttttg ttgtgtaaaa 1344061 gggcaaatgt aaacggttaa actggaagac ttacgcctgt gaattcgttg tcatgatttt 1344121 tagctgtaag gtcagactag taaaaagagg aggtcaattc ttatgtttaa agcattattc 1344181 ggcgttcttc aaaaaattgg gcgtgcgctt atgcttccag ttgcgatcct tccggctgcg 1344241 ggtattttgc ttgcgatcgg gaatgcgatg caaaataagg acatgattca ggtcctgcat 1344301 ttcttgagca atgacaatgt tcagcttgta gcaggtgtga tggaaagtgc tgggcagatt 1344361 gttttcgata accttccgct tcttttcgca gtaggtgtag ccatcgggct tgccaatggt 1344421 gatggagttg cagggattgc agcaattatc ggttatcttg taatgaatgt atccatgagt 1344481 gcggttcttc ttgcaaacgg aaccattcct tcggattcag ttgaaagagc caagttcttt 1344541 acggaaaacc atcctgcata tgtaaacatg cttggtatac ctaccttggc gacaggggtg 1344601 ttcggcggta ttatcgtcgg tgtgttagct gcattattgt ttaacagatt ttacacaatt 1344661 gaactgccgc aataccttgg tttctttgcg ggtaaacgtt tcgttccaat tgttacgtca 1344721 atttctgcac tgattctggg tcttattatg ttagtgatct ggcctccaat ccagcatgga 1344781 ttgaatgcct tttcaacagg attagtggaa gcgaatccaa cccttgctgc atttatcttc 1344841 ggggtgattg aacgttcgct tatcccattc ggattgcacc atattttcta ttcaccgttc 1344901 tggtatgaat tcttcagcta taagagtgca gcaggagaaa tcatccgcgg ggatcagcgt 1344961 atctttatgg cgcagattaa agacggcgta cagttaacgg caggtacgtt catgacaggt 1345021 aaatatccat ttatgatgtt cggtctgcct gctgcggcgc ttgccattta tcatgaagca 1345081 aaaccgcaaa acaaaaaact cgttgcaggt attatgggtt cagcggcctt gacatctttc 1345141 ttaacgggga tcacagagcc attggaattt tctttcttat tcgttgctcc agtcctgttt 1345201 gcgattcact gtttgtttgc gggactttca ttcatggtca tgcagctgtt gaatgttaag 1345261 attggtatga cattctccgg cggtttaatt gactacttcc tattcggtat tttaccaaac 1345321 cggacggcat ggtggcttgt catccctgtc ggcttagggt tagcggtcat ttactacttt 1345381 ggattccgat ttgccatccg caaatttaat ctgaaaacac ctggacgcga ggatgctgcg 1345441 gaagaaacag cagcacctgg gaaaacaggt gaagcaggag atcttcctta tgagattctg 1345501 caggcaatgg gtgaccagga aaacatcaaa caccttgatg cttgtatcac tcgtctgcgt 1345561 gtgactgtaa acgatcagaa aaaggttgat aaagaccgtc tgaaacagct tggcgcttcc 1345621 ggagtgctgg aagtcggcaa caacattcag gctattttcg gaccgcgttc tgacgggtta 1345681 aaaacacaaa tgcaagacat tattgcggga cgcaagccta gacctgagcc gaaaacatct 1345741 gctcaagagg aagtaggcca gcaggttgag gaagtgattg cagaaccgct gcaaaatgaa 1345801 atcggcgagg aagttttcgt ttctccgatt accggggaaa ttcacccaat tacggatgtt 1345861 cctgaccaag tcttctcagg gaaaatgatg ggtgacggtt ttgcgattct cccttctgaa 1345921 ggaattgtcg tatcaccggt tcgcggaaaa attctcaatg tgttcccgac aaaacatgcg 1345981 atcggcctgc aatccgacgg cggaagagaa attttaatcc actttggtat tgataccgtc 1346041 agcctgaagg gcgaaggatt tacgtctttc gtatcagaag gagaccgcgt tgagcctgga 1346101 caaaaacttc ttgaagttga tctggatgca gtcaaaccga atgtaccatc tctcatgaca 1346161 ccgattgtat ttacaaacct tgctgaagga gaaacagtca gcattaaagc aagcggttca 1346221 gtcaacagag aacaagaaga tattgtgaag attgaaaaat aagggtgtta gtacgccgtg 1346281 cttgtcagat gacaagtacg gttgtatgat ataatattgt gaagtaataa agctttaagt 1346341 taaaaggaga atgataaaaa tggcacaaaa aacatttaaa gtaactgcag attctggaat 1346401 ccatgctcgt cctgcgacag ttcttgtaca aactgctagc aaatacgacg ctgacgttaa 1346461 tttagaatat aacggcaaaa cagttaacct taaatctatt atgggtgtta tgtctttagg 1346521 tatcgctaaa ggcgctgaga tcacaatctc tgcttccgga gctgacgaaa acgatgctct 1346581 taacgcttta gaagaaacaa tgaaaagcga aggactcggc gagtaatgca agaattaaaa 1346641 gggattggtg cttcagccgg catcgcgatt gcaaaagcgt accggcttga agagccagat 1346701 ttaacggttg aaaagaaaaa catctctgat tctgaagcgg aagtaagccg ttttgatgaa 1346761 gcgattgcac gttcaaaaga agagctcgaa aaaatcaaag agcacgcttt gaaagaactg 1346821 ggtcaggata aagctgatat tttttctgct caccttttag ttctcagtga ccctgagctt 1346881 ctgaaccctg tgaaagaaaa aatcagcact gattcagtga acgctgaatt cgctttaaaa 1346941 gaaacgtctt ctatgttcgt tactatgttt gaatctatgg acaacgaata tatgaaagag 1347001 cgtgcggcag atatccgcga tgtaacaaaa cgcgtaaccg gccacctgct tggcgtcgaa 1347061 attccaaacc caagcatgat ctcagaagag gttattattg tagctgaaga cttaacaccg 1347121 tctgacacag ctcaattaaa ccgtgagttc gtaaaaggat tcactactga tatcggcgga 1347181 cgcacatctc actctgccat catggcacgt tctcttgaga ttccagcagt tgttggaacg 1347241 aaagctgcta caggcacgat ccaaaacggc gtgactgtta tcgttgacgg tatcaatggc 1347301 gatgtcatta ttgacccatc tgcggaaact gtaaaagagt atgaagaaaa acataatgct 1347361 tatttggctc aaaaagctga gtgggcgaag cttgtcaatg aaccgactgt ctcaaaagac 1347421 ggacatcatg tagagcttgc agcgaacatc ggtactcctg atgatgtaaa aggtgttctt 1347481 gaaaacggcg gagaagcagt tggcctttac cgtacagaat tcctttacat gggaagagat 1347541 cagctgccta cagaagatga gcagtttgat gcttacaaaa cggttcttga gcgtatggaa 1347601 ggaaaatcag tcgtcgtgcg gacacttgat atcggcggag acaaagagct tccttacctg 1347661 cagcttccta aagaaatgaa cccgttcctg ggatatagag cgattcgtct ttgccttgaa 1347721 gagcaagaaa tcttcagaac acagcttcgc gcgctgcttc gtgcaagtac atacggaaac 1347781 ttgaaaatca tgttccctat gattgcgaca gttaacgaat tcaaagaagc aaaagcgatc 1347841 cttcttgaag agaaagaaaa gctcgtaaaa gcgggacagg ctgtatctga cgatattgaa 1347901 gtcggaatga tggttgagat tccgtcaact gcagtcatcg ctgatcagtt tgctaaagag 1347961 gttgatttct tcagtatcgg aacaaacgat ttgattcaat acacaatggc agctgaccgt 1348021 atgaatgaac gtgtatctta cctgtatcag ccatacaacc cggcaatcct tcgcttaatt 1348081 acactggtaa ttgaagcagc acacaaagaa ggaaaatggg ttggcatgtg cggagaaatg 1348141 gcaggagacg agattgcgat tccgatcctt ctcggcttag gcttagatga gttctcaatg 1348201 agcgcaacgt ctatccttcc ggcaagaaca caaatcagca aattgtctaa acaagaagct 1348261 gagtcattca aagagaaaat cttatctatg agcacgacag aagaagttgt cgcgttcgta 1348321 aaagaaacat tcaagtaatg tacaaaaacc agacggcctc cggcctgtct ggtttttttc 1348381 ataagtaagg gtatagaagg acacaataac atggctagga gggatagtat gtcaaaccaa 1348441 tttaacgcag gagatactgt ttatgtgatc tacagaaatc cgcacgccgc caatgtagcc 1348501 cacataaagg aagccgaaat tgtgcaccat ccataccatg aaggcgagct ttccctgttt 1348561 atttatgaaa cctatcatcc attcgcagag gacgatgctg tgtttgcaag ctatgaagaa 1348621 gctaaatcgc tttacaaaga actgtttgat attgatccgt atgagtaaca aggaaatcat 1348681 tacaactcat atcctttccg cctagtgaga aaagtaacgt tagtaaagga aaaggatgtg 1348741 gcatcatgca gaacccattt gttccgcagc ttgtgtatat agaaccgagg gcgctggaat 1348801 atccgctggg ccaagaatta caagataaat ttgagaatat gggtattgaa atcagagaaa 1348861 cgacatccca caatcaggtg cgtaatatcc ctgggaaaaa tcatcttcag caatatcgca 1348921 atgcgaaatc aactttagtt atcggtgtcc ggaaaacatt aaagtttgat tcatccaaac 1348981 cctcggccga atatgccatt ccgtttgcaa caggctgcat ggggcattgt cattactgct 1349041 acctgcaaac aaccatggga tcaaagccgt atatcagaac ttatgtaaac gtcgaagaga 1349101 ttttagatca ggcagataag tatatgaagg agcgcgcacc agagttcaca aggttcgaag 1349161 catcatgtac gtcagacatt gtaggaattg atcatctgac acacacgctg aagcgcgcca 1349221 ttgaacattt tggccaaagt gatctcggaa agctccgatt tgtaacgaaa tttcatcatg 1349281 tcgatcacct attagacgca aagcataacg ggaaaacgag attcagattc agtattaatg 1349341 ccgactatgt gattaaaaac tttgagccgg gaacttcacc tcttgataag cggatagaag 1349401 cggcagtaaa agttgcaaaa gcaggctacc cgctaggctt tattgttgct ccgatttata 1349461 ttcatgaagg ctgggaagaa ggatacagac atctgtttga aaagctagat gctgctttgc 1349521 cgcaggacgt tagacatgac attacgtttg aattaattca acaccgtttt acaaaaccgg 1349581 ccaaacgagt gatagagaaa aattatccga agacgaagct cgaattagat gaagaaaagc 1349641 gccgttataa atggggccgt tacgggatcg gaaaatatat ttatcagaaa gatgaagagc 1349701 atgcacttcg agaggcactt gaatcctata ttgatacctt tttccctaac gcaaaaattg 1349761 aatatttcac ttaaacgggc tgttgtgatc aacagctcgc ttttttataa aaaacatttt 1349821 tccattccat caaaacgccg taattcaatg attctttatc ctccaaataa ttgctgacta 1349881 cacgaatagg tgaacgcccg caacggagga gaaaggacag cacagggtcg tttttcctgc 1349941 cttccatcac atcttcaacg tactgaacag cgctgatctc gtgtgcgtat ttataataca 1350001 aaggaatgcg gccgccgccg agaaggcgtt ccagtctttt atcaacagtc agctcataca 1350061 tcgtattcat cagccatttt ccgattccaa gctttcgata atgaggagaa acagaaatat 1350121 ccactacata taaagtattt ccatgaggtt catgattttt aatcgatccg ttgtcagttg 1350181 cttgtgccca tgtatgatca ggagaatcag gctcaaattg tacaataaga gcagtcatgg 1350241 aaccgataat tctgccattg atgagcgcgc ataaagcgcc ttccggaaag gttttgatat 1350301 ggctggcaag ctggtcctct gaccacagca attcctgggg aaacggagga gggaaacatt 1350361 cttcttgaag agaaatcagc ctctcgatgt cagtctcagt gtagtttcta atggtcagag 1350421 cctcaaattt tctgccgtca tgcacataca tttgttttag tatgatcatc actctcctta 1350481 tgttgtttca ttataacgaa gattgaattt tcagtaaata tattccgatt ttcttataat 1350541 ttattttttg attattcatt tttcaaacga aagggccgat atagaaatta ggaggggatt 1350601 ggtttgttta aaaaacttca catgaagatt gctgtttttg tttcgattat gttaatcatc 1350661 acagttgttc tcttaatgct gtcttcttat ttgacgctaa aaccgatgat tacagaggat 1350721 gggaaaaata caactcaaaa cgtgacgcag tcacttgaac aaaatattga attgcaatta 1350781 aagagttatg ccatttcgtt atcaagattg gctaatgggg aattaacgca tacatttgta 1350841 acgaaaccaa gtaaagaagc ttctcggctg tttcacgatg acattaagca aatcaaagac 1350901 aacgatgatt atgttgcgat ggcttacata ggcaccgcaa aaaaagaaat gtttacatat 1350961 ccaaaagcgg atttcgctga ggattacgat ccaacatcaa gaccatggta taagcttgca 1351021 gctgaaaccc cggatcaagt tgtttggacg gaaccttata aagatgtcgt gacaggagac 1351081 atgattgtta ctgcatcgaa agcgatctta gacaggcaaa aagtgatagg ggttgccagc 1351141 tatgacttga aactctctgc tatccagagt atggtcaata aacaaaaggt gccttacaaa 1351201 ggatttgcct ttttagctga tgcgagcggc aatcttttag cccatccgtc aaatcaagga 1351261 aaaaatatat caaaggatca aacactgcaa accatcgcat ccgagaaaaa agggatacaa 1351321 gatgtgaatg ggaaaatggt tgtgtaccaa acgattggcg agacaggctg gaaggtcgga 1351381 acgcaatttg ataccgatca attaatgtgg atttcagata aaatgaatcg ggccaatctt 1351441 tggatatcat tgattgcgct tatcataaca attattctca gctacttcct ggccaaaacg 1351501 ataaccggtc cgatacagca gctgatcgta aaaacgaaag ctgtttccgc aggcgattta 1351561 acagtgcgcg cggaatcaaa atctaaggat gaagtcggta ttttaacaag agatttcaat 1351621 ctgatggttg aaaatatgaa ggaaatggtt gagcaagtga gactctcttc agggaaagta 1351681 tctgacacct ctgaacaact aacggctgtg gctgccgaaa ctaatgaaac aagcggacaa 1351741 attgcaaaag cgattgaaga agtagccgca ggggcatcgg aacaggcttc tgaagttgaa 1351801 accattaatg aaaaatcgga aagcctgtca acgaaaatca ggcaaatcgc tgaggaggca 1351861 ggcggaatta aagaacgctc aaaatcgtcc gaggatgcaa gctataaagg acttgacgcg 1351921 ctcggccagc tgctgatgaa atcaaacgaa gccaatatgg aaacgaaaaa ggttgaaacg 1351981 atgctgctgg atttggaaaa tcaaactaag aatattgaag aagtcgttac agcgatttca 1352041 aacatatctg atcaaaccaa cttgcttgcc ttaaatgcca gtattgaggc agccagagcc 1352101 ggagaaagcg ggcgcggttt tgccgtcgta gccgatgaag tgcggaagtt agctgagcaa 1352161 tcagcccttt ctacaaagca tatcagcgag actgtgaagc ttatccagct tgagacaaaa 1352221 gaggcctctc acgcgatggt tgaggcaagc agaatgaatg atgaacaaaa cagtgcaatt 1352281 cacgaaactg gagaggtatt aaatacgata actgcagaaa tgcagtcact ggtacaaggt 1352341 attgatcaca tttacgcgga aattcaaaga atgagtgaag aacagcttgc gatttctgaa 1352401 gccattcaaa gcatttcagc catatcacag gaatcagctg ccgcagcaga ggaagtgaac 1352461 gcatcaaccg atgaacagct tgtcaccctt gataaagtca aacactcaac ggaaacacta 1352521 aaacatgcaa gccaagagct tatgaacaca attgcaaaat tcacattgta atccaattac 1352581 atccccaaac atcatttgtt ttggggattt tttattttat aagatgaata gatatggtag 1352641 tctagaaaat gaaggaaaaa tgataaattt taactaaaat ctaaacgaaa catctgggag 1352701 gaatgacctt gaaaaaaaca attggtttta tcggtcttgg agtaatggga aaaagcatgg 1352761 catcacatat tctcaatgac ggccatcctg tattggtgta cacccggaca aaagaaaaag 1352821 cagaaagcat acttcaaaaa ggcgcgatct ggaaagatac ggtcaaagat ctttcgaaag 1352881 aagcggatgt tatcatcaca atggtcggct atcccagtga tgttgaagaa gtgtatttcg 1352941 gaagcaatgg aattattgaa aacgcaaaag aaggtgcata tcttattgat atgacgacat 1353001 ctaagccttc gcttgcgaag aagattgctg aagcggccaa agaaaaagca ttgttcgctt 1353061 tagacgctcc tgtttccggt ggagacatcg gtgcacaaaa cggaacactc gcgattatgg 1353121 tcggtggaga aaaagaagct tttgaagcct gcatgccgat tttctcttta atgggagaga 1353181 atattcagta tcaaggaccg gctggaagcg gacagcatac caagatgtgc aatcagattg 1353241 caattgcagc cggtatgatc ggtgttgctg aagcgatggc ttatgcccaa aaatcaggcc 1353301 tagagccgga aaatgttctg aaaagcatca caacgggcgc agccggaagc tggtcattgt 1353361 caaatcttgc tccccgtatg ctgcaaggca actttgaacc gggattttat gtgaagcatt 1353421 ttattaagga tatgggaatt gcactagagg aagcagaatt aatgggggaa gaaatgccag 1353481 gcttgtcgct cgcaaaatct ttatatgaca agctagctgc tcaaggtgaa gaaaacagcg 1353541 gaacacagag tatatataag ctttgggtga aataaaaaaa gattgcctgt acgaaacagg 1353601 caatcttttt ttattatttt ccgatgaatt gttgtgtcca gatgcttcca gactcaacgt 1353661 aaccaacacc gatgtgagta aagttagggt ttagaatgtt ttttctgtgt ccttcactgt 1353721 tcatccaagc ttttactact tcttctggtg tcttttggcc cttcgcaatg ttttcacctg 1353781 ctgttttgta gctgattccg aaagatttca tcatatcaaa cggtgagccg tatgttgggc 1353841 tttggtgatc aaagtagttt ttgtctttca tatcctgaga ttttgcgcgt gcagatttgc 1353901 ttaacgtttc atcaatttga agcggtttta agccttgttt ttgtctttct gcatttgtaa 1353961 gttcaacaac ttttttctca tatgcactta cagatgaagg tgcagacgtt gttgtgtttg 1354021 ttttttcagc agttgcgggt gctttagaag cagtgttttg atcagcagct gctttttcag 1354081 tagtcttttg tgcaggtttt gccgtttctg tcttttgaac atcctgaact ttcacgttag 1354141 attgcttcgc atgtttttga agaagctgct tcatctcttt ttcgtttgca gcgtttaacg 1354201 ttttgatatt tgtgttaata tgcagttttt tcactgcatc gttaagtgac atgttttgta 1354261 ctgtgttccc cgtttttact gtaaccacag gctggcagga gagttctttc gctgatgctt 1354321 gctgtacgcc cccgaatgtg aataatccaa ccgcagcggc agcagataaa ataaatgctt 1354381 tcttcattag ttcgtaacct cctagagttg tttgtttcta cagaaaaatc ataacatagc 1354441 ttttttgtca taaagattcc agcactttcc tttgacaaat agagattgtc attttcgtaa 1354501 agtaaatccg ttgaatcact aagaataagg gaatcagcgg tatatatgat tttatcgtac 1354561 cgttacatag cttccttttt tttgaaccgt tagttatatt ttaatgtgtt tttatattga 1354621 cagctttttt tactcctttt cgctgtaaca actattacaa aggtgttaca attaatctca 1354681 gtatatgtaa atatattgaa tgatttgaga ggggtaacca gaagtgactg aaataggacg 1354741 tgaaccaaag aaaaagagca aaggaaacag agcaatcaga atgaaccttt ttttcctagc 1354801 tgtctttgtt ctattcactg cattaatttt taagctcggg gttgttcaaa ttgttgaagg 1354861 cgaacagcat gaagaagacg ctgagaaatc aaatgcaaaa acagcttact atcctgcgcc 1354921 tcgcgggaag atgtacgaca gaaaccagaa agttgctgtc gacaaccaga gcgttccaga 1354981 aattgtgtat gtatcaacat ctagcacaaa aacagaagat aaaatcaaaa cagcgaagcg 1355041 gcttgcttct ttcattcata ttgataccga atttttgaag gaaagggatc ttcgtgatta 1355101 ctggatcgca gctcatccga aaaaagccgc cgctctgctt aaggaatcag aaagcaatct 1355161 gaaaggagac caggcttaca agcttcaaat agagcgtgtt ccggatcaag aattaaaggc 1355221 tattcagcaa gatgacgaag aaatggaaac tgctgcgata tatacaaggt tttcaagcgg 1355281 aaatgcttac gaacctcaaa tcgtaaaggc aatgaatcca aataagagca atagcaatgg 1355341 aaaaaacgga gcgctgcttg atgagaagaa aaactcctcg caaagaccaa aaaatgactt 1355401 aacatatgat gaaatttcca ttgtttctga gcatttagaa gaacttccgg gaatcgatat 1355461 cgtaaacgat tggacacgaa aatatcctta tgacaaaacc ctttattctg ttttcggggg 1355521 cgtcacgaca cctgatcagg gcctgctgag cgaccggaaa gatttctact taacaagagg 1355581 ctatgcgaat aatgacaggg tgggaaaaag ttatttagag tatcaatatg aagaatattt 1355641 aaattcgcat aaagaaaaag tggaatacgt agaagataat aaaggaaatg tcgtcagcca 1355701 aaaaaccatt gataagggca gcaggggata cgatcttcag ctttcttttg acatggagct 1355761 tcaggcaaag gtagaaaaga tcattgaaga agaagtaaga aacagccgtg cacgcggaaa 1355821 ttacatgctt gacagagcct ttgccgtaat gatggacccg aataacggcg atattttatc 1355881 aatggcaggg aaaaagatag atttaaaaac caacaaaatt gaagattatg cgataggggc 1355941 atttaccacc caatatgaaa tgggatcagc agtaaagggg gccaccgtgc tagccggcta 1356001 tcaggacggg atcccgcatt ataaatatta tatcgatgct ccaatgcttt taggaacgaa 1356061 tcttataaaa aaatcttata ctaatatggg aaccatcaat gaattaaccg cattgcaaaa 1356121 aagttcaaac gtatatatgt tcaatgttgc catgcatatt gcaggcgtaa catacaagcc 1356181 gcatggatct ctcccggctg atcagaacga tctactgaaa atgagaaact attacagcca 1356241 gtttggtctg ggagtaaaga caggtattga tctcccgcag gaatcagccg gaatgcaaac 1356301 cacacctaaa actgtaggag gattaatttt agacttagca attggccaat acgatacata 1356361 cacaccgctt caaatggctc aatacatctc agtaatcgcc aatggtggct atcgtgttca 1356421 gcctagaatc gtcacaagta ttcataagcc aggaaaaaaa gaccagctgg gtaaggcgat 1356481 tgaacatagg aaacctaaag tactcaataa gattaataat tcagagagcg atttgaaaca 1356541 agtacaaaca ggcatgaaat tagtcacttc ttcagggaca gcaaaaaata cgtttacaga 1356601 agatgtatca gggaaaacgg gaacagcgga aacattttac tacggcacga atcgcaactg 1356661 gtgggggaaa aaaacataca atctgacttt tgtcggctat tacccgtcga aaaaaccaaa 1356721 agtggccttt agtgttgttg ttccatcagt agatgatgat gataagatca ataaaattat 1356781 tgccaaaaga gctatccacg cctacgcaga gctcgaaaaa aaacacagta aaaaataaaa 1356841 aacagggtgc acaactaaaa gattgtgtgc cctttctttt attcaaaaat tgacgttcac 1356901 cataagaata gaaggagaat actcattttc tagcgaatca tactaggtaa aagtcaatct 1356961 gtatatgtcg aaacacgatg atcatgcaaa ggagggattc tgtggaacag gatacgcagc 1357021 atgttaaacc acttcaaaca aaaaccgata ttcatgcagt cttggcctct aatggacgca 1357081 tcatttatat atctgccaac tccaaactgc atttgggcta tctccaagga gagatgatcg 1357141 gatcattcct caaaacgttt ctgcatgagg aagaccaatt tttggttgaa agctattttt 1357201 ataatgaaca tcatctgatg ccgtgcacct ttcgttttat taaaaaagat catacgattg 1357261 tgtgggtgga ggctgcggta gaaattgtta cgacaagagc tgagcggaca gaacgggaaa 1357321 tcattttgaa aatgaaggtt cttgaagaag aaacaggcca tcaatcccta aactgcgaaa 1357381 aacatgaaat cgaacctgca agcccggaat cgactacata tataacggat gattatgaac 1357441 ggttggttga aaatctcccg agtccgctat gcatcagtgt caaaggcaag atcgtctatg 1357501 taaacagcgc gatgctttca atgctgggag ccaaaagcaa ggatgctatt attggtaaat 1357561 cgtcctatga atttattgaa gaagaatatc atgatatcgt gaaaaacagg attatacgaa 1357621 tgcaaaaagg aatggaagtc ggaatgattg aacagacgtg gaaaaggctt gatggcacac 1357681 ctgttcattt agaagtgaaa gcatccccga ccgtctacaa aaaccagcag gctgagctgc 1357741 tgctgctgat cgatatctct tcaaggaaaa aattccaaac catcctgcaa aaaagccgtg 1357801 aacgatatca gctgctgatt caaaattcca ttgataccat tgcggtgatt cacaatggaa 1357861 aatgggtatt tatgaatgaa tcgggaattt ccctgtttga agcggctaca tatgaggatt 1357921 taattggcaa aaacatatac gatcagctgc atccttgcga tcacgaggat gtaaaagaga 1357981 gaatccaaaa cattgccgag caaaaaacag aatctgaaat tgtcaagcaa tcctggttca 1358041 cctttcagaa cagggtcatc tatacggaga tggtctgcat tccgacgacc ttttttggtg 1358101 aagcggccgt ccaggtcatt cttcgggaca tctcagagag aaaacaaaca gaagaattga 1358161 tgctgaaatc ggaaaaatta tcaatcgcag ggcagctcgc ggcgggaatc gcccatgaga 1358221 tccgcaaccc tcttacagcg atcaaaggat ttttacagct gatgaaaccg acaatggaag 1358281 gcaacgaaca ttactttgat attgtgtttt ctgaactcag ccgtatcgaa ttaatactca 1358341 gtgaactgct catgctggcg aaacctcagc aaaatgctgt caaagaatat ttgaacttga 1358401 aaaaattaat tggtgaggtt tcagccctgt tagaaacgca ggcgaattta aatggcattt 1358461 ttatcagaac aagttatgaa aaagacagca tttatataaa cggggatcaa aaccaattaa 1358521 agcaggtatt cattaattta atcaaaaatg cagttgaatc aatgcctgat gggggaacag 1358581 tagacattat cataaccgaa gatgagcatt ctgttcatgt tactgtcaaa gacgaagggg 1358641 aaggtatacc tgaaaaggta ctaaaccgga ttggagagcc atttttaaca acaaaagaaa 1358701 aaggtacggg gcttggatta atggtgacat ttaatatcat tgaaaaccat cagggagtta 1358761 tacatgtgga cagccatcct gaaaaaggca cagcgtttaa aatttcattt ccaaaaaaat 1358821 aaaaacaacg gcttaaacgc cgttgtttat cgtctgcatt gcttcacgtt tttttaatac 1358881 aaataattct aaacggtcta ggccttctct cagcgtgtcc attgagcatg caaaagacag 1358941 ccttacatat ccttcaccat atgttgagaa cgagctgccc ggcacgagtg ccacgccagc 1359001 gtcttccaaa agagccatac taaaatcaaa tgaagtcatt ccaaatgatt taatagaagg 1359061 gaagatataa aacgcaccgg acggtttaac tacgtcaagt cccatggaaa caagacggtc 1359121 ataaacatag tccagacgtt ttttgtattg ttctctcata atcaatgcat cgtcaaagcc 1359181 gtttgtgaca gcttcaagcg cggctttttg agaaatggat gaggcgcacg acacattgta 1359241 ttgatgaacc tttaaaatgt gctttgcaat gtctttcggt gcaaataaaa atccaattct 1359301 ccaaccggtc atgctgtgtg attttgacaa cccgttaatg acaatcgttt gatcccgcaa 1359361 ataggttgcg atggagtaat gcggtctgtc atatgttaat tcactgtata tttcatcaga 1359421 caatacgaag acatttctgc cttttaagag agctgcgatg cttttcagtt cttcttcaga 1359481 taaagtcacg ccggtagggt ttgacggata aggaagcacg acacacttgg tgttgggtgt 1359541 cagagcatct tcaatcagcc gggcggtaag cttaaagccg tgtgacgtag tatcaacaat 1359601 gacaggcttg gccccgcaca aattgataat aggttcatag cccggataaa taggccctgg 1359661 cataatgact tcatcaccgg gagataaaat cgtccggaat gcagcatcaa tggcttggct 1359721 tgcgcctgtt gtgatgataa tttcagattc agcatcatag ttgaaatccg cttttttctt 1359781 catataaagc tgcacagctt gtctcagctc caggtagccg gcattcggag tatatgacgt 1359841 cacgttttca tcaatggctt tttttgcggc agctttcaca tgatgcggtg tgaaaaaatc 1359901 aggctggccg attgtaagtg aaatgacgtc ttcgtgttgg gctacaagat tcgagaattt 1359961 gcgtattcct gaaatttcga tctctcttgc tttcggattc agcaaatgtt ccataattca 1360021 tcaccttaac aaatataatg agtttatcct attttaccac tagctgatca tttgtcacct 1360081 ttttaactga tatatttcga ttgtatgcgc cttttttcta aacatacctt tcttttcaga 1360141 aaaaaagaag acaaccagcg atttgattgt ctttattgta tcatgttcta ttattgttta 1360201 tatgtgccaa tttcattaat agccataatc aaaatgaagg tcttcgtgcc aaatcagata 1360261 cggaggatgc tcttcttgaa ggtcagctga ttctttcttc atattcaggt aagtttcttc 1360321 actgatatcc tctaaaacag tcatttcgtt ttctttaaat attactaagg tacccattat 1360381 ttacaccctt ctttggaaaa atccttgact attttatcac tgttagttgg aaagtcaatg 1360441 gttattagga aaaaagtttc ttttttgagg aacgcggctt gttgccttcg gaattcgatt 1360501 ttgaagagct gccattcact ttttacaaat tacgccgata tatacagtac aatactgaat 1360561 gcgaatagcg agggattgaa ttgtcgttac aacaatacga aattttattg gattctggta 1360621 caaatgaatt agaaattgtg aagtttggcg tgggtgaaaa tgctttcgga attaacgtca 1360681 tgaaggtaag agaaattatt cagcctgtcg aggtgacatc agtgcctcac tcccatcagc 1360741 atgtagaagg aatgattaaa ctcagaggag aaatcctccc tgtgatcagt ctcttctcat 1360801 tttttggagt agagcctgaa ggatcaaaag atgagaaata tatcgtgact gaatttaata 1360861 aacggaaaat tgtttttcat gtcggctctg tttctcaaat tcacagagta tcctgggaag 1360921 cgattgaaaa gccgacatcg ttaaatcaag gaatggagcg gcaccttacc ggtattatta 1360981 agctcgaaga cctgatgatc tttttgcctg actatgaaaa aattatttat gacattgaat 1361041 cagattcagg tgttgacacg tataatatgc ataccgaggg cttcgatgaa agaagaactg 1361101 ataaaaagct tatcattgta gaggactcac cgcttttgat gcgcctcttg caggatgaat 1361161 taaaagaagc agggtacaac aatatcgctt cgtttgaaaa tggaaaagag gcatatgaat 1361221 acattatgaa ccttgctgaa aacgaaactg atttatcaaa acagattgat atgatcatca 1361281 ctgatattga aatgccaaaa atggacggac acaggctcac aaagctgctg aaggaaaatc 1361341 cgaaaagctc agatgtgccg gttatgattt tctcatcgtt aattacggat gatctgcgtc 1361401 accgcggcga agttgtaggc gcagatgagc aaatcagcaa gcctgagatc agtgatttga 1361461 ttaaaaaagt ggatacgtat gttattgaat aaataaaaac agccgttgcc agaaagaggc 1361521 acggctgttt ttattttaaa agtaactctc gccaagtttt ttaaagaccg gtttatggta 1361581 agctggctgc tggcgatttg gcactagcgg cttttctttc atgccgacat attcttgcaa 1361641 taggtgtttc gcttttgtta aagacatttg agctttagga tttcgatacg attgattaag 1361701 tgtacctaaa tgcggaagat gttcgaagtc ttctttagtt ggaggcatgt gaaaatagta 1361761 gtctccgatt gagataagca cgtccgattg ctgttggctg aaccttggat tttttgaaaa 1361821 atgaagccct attttctttc ctttaccttc tttgacaagc ttttgcaaag cccgtttttt 1361881 cagcagatat aggtatttag ggttgggggc ggtttttgca tggcggttca cagtgtaaac 1361941 tgcttttgaa agattttcta cggttggctg cagatctttc gtatatgcat ggtcgtccat 1362001 tatttctctc ctttgctctt atcaatttct atatgtttag attatacttt tttaaagttg 1362061 aaatgcaaat attgaatgta aaaatgcgct tttttctaag aaaaaaagcg catttttaac 1362121 ctgcattata cagatcttgc cttctttttc ggctgttctt gaaatgcttc ctgaacattc 1362181 acttccacag cctgagcact gtattttggc agtgcaataa aataaaaaat aaaaacgagc 1362241 aggataataa cacccatgcc gtaataaaga taatcaatgt ttgaaacaaa cttagggaat 1362301 aacagcgcga ctaagccgag tgtcaaagat tgtgcaaaca tcataaaagg gtcctgcatg 1362361 ccgcttacac gtcccatcag ttttggatga acaatttttg gcatccaccc tccgattgca 1362421 atgttgatcg gtccgataca cattcccagt gcaaaagctg ccgcgtaata cacccataaa 1362481 atattggtgt agccgaggac gaagatcagc aaacctgcaa tgaaaatcgg tatcgacatt 1362541 aaaaagtgcg gcttcacttt tttagagatg agcgtgccga ttacgcttcc tgccagaagc 1362601 ccaaacccga gtgcgatcgt aaatacagac gtatgccact cataacggtc aggcgccaat 1362661 ccatatttca ttgtaaacat cggcaatacg gcgaatcctc cattgacaaa tccaaaaatg 1362721 aagaagccaa aaataagaga tgccagcaat ttgtttttta aaatatagag gatgccttct 1362781 ctaaagtcat ttattgaatc cttaacagaa gtctttctcc agctgaatgc accgtttggc 1362841 tgtcgggctt cttttggaat ccggcagctg cggatcagca gcccggaaat gataaagctg 1362901 acaaaatcaa gaataatggc gccttcaata ccgattgtgt tgtacataaa cgcgcctatg 1362961 ccgactccaa acaccataaa aatgctaaaa agcatctgat taagccctgc cgctttcgca 1363021 taatgctcct tcggcagaat ggcttgtacc aaactgtttt ctgccggaaa gaaaaacttt 1363081 gttacagcgc ttctgataaa taagatacaa aaaacaagag gaatattgcc ggtaaataaa 1363141 gtgaaaaaaa gcacgacagt caggcctgct ctgatccaat cacaattttc tgccaccttt 1363201 tttctatcaa accggtccgc gacgactccc acgatcagaa atacaaatat ggtcggaaga 1363261 gaatacatca gctccgccaa ggtcgtatat gaaggctggc tgctgaatcg gtccagcaaa 1363321 aaaaaagcaa aggccatgtt gcctactgtc gtgcccattt gagaagcgag tgctgcgaaa 1363381 aatagacgaa caaaattacg atttttaaat atatccataa aaacgctcct taccctaaag 1363441 gtcccacttt atcatattat aaaccgcctg tttttgaaac aaataagaaa acattaccgg 1363501 ttaatcgtga ctctcgttcc gtttggcaca attgaagcaa gttcgatcac gtctttgtta 1363561 tgcatgcgaa tgcagccttt agaaacagcc ttaccaatcg aagcgggatt attcgtccca 1363621 tgtattccgt agtgctgctt tgaaaggctc agccaataag cgccaaatgg gccgccggga 1363681 ttgcgctggc ggttaataat gtaaaactcg ccagtaggcg tttgcgttag tattttacca 1363741 acggcgatgg gataggtttt cattacccga ttatttaggg acagcgtaag ggtcttcgct 1363801 ccgattgaga ctgcgatatg atacggaatt gtataagggt ccggcagtcc ggggatgact 1363861 atggactgtc ccgcggtgag ccctgcctgc agtgacggat tagcctggag taatgcagcc 1363921 gtgctgattc tgaaatcagc cgcgatgctg ttcagtgtat caccttgctt cacctggtac 1363981 gtaagcagtt tcctcatcct ccttttttac ttataagtat tgatgaggag cccatcctgc 1364041 tacattaatt tgtgcttttt aaggtgaaga cagtgatttc aggcttggca agaaaccgca 1364101 aaggcagcct ggtcatcccg aggcctcggt ttacgtaaat atgagtgctg cccgtttgat 1364161 acattccctc tgtgtagact tttccatatg gaggcgtaat aatcggtccg taaaaaggca 1364221 gctgaatctg gccgccgtgt gtatggccgg aaagctgaag gttcacggga taatctgttg 1364281 ttttcaaggc tgcatcaggt tcatggacga gaagaatgga aaaaagtctg tcgctcagcc 1364341 ttgaaagggt gccttcataa tctgggtttc ccagcattaa gtcatcaagc gaagcaatct 1364401 cgattttgct gccatctgcg agtgacaatg tttgatagcc attgcgatat accgtgaaac 1364461 ctccggccgt catcaggctt ttgtaaacgg cagttccata gcctccgtga tcatgattgc 1364521 cgtaaataca aagcttgccg aagggagcat taagctttct caataatgga atgactgcct 1364581 ggtggtgctg gtacgtatca ggattatcaa taatatcacc tgtaaaaaca atgagatcag 1364641 gtttagattc attaattgta agaatgacag tttttaaatc ttcgagagta aagtaatcac 1364701 tcaagtgtgc atcgctgaac tgcacgattt taaaaccgtc aaatccgtgc gggatgagag 1364761 agctttttat tgtgtgttcg gttgtctcga tcatatgcgg ctcgagatac ctggcatagc 1364821 catatccccc gccggccgtt aaagccccgg cagcaagagc gccgaacatt ccttttagaa 1364881 attgtcttct ggacatcttt ttcatttcaa accaaccttt aatagagttt ttctattata 1364941 tcatctgtat ctgataaaaa tctcatatga gcatgtgctg acagaggcag ggatataatg 1365001 atagaatatt attgaatgaa taatcattca caattggagg gataaacatg gaaaaaaagg 1365061 cggtaattat taccggcggg tcaagcggca tgggaaaagc gatggcaaaa aaacaggctg 1365121 aattagggtg gcacgttatg gtgacaggga ggaaccatga ggcacttgag gaaacaaaaa 1365181 aagaaattca gacctttgag ggacaggtcg cttgttttca aatggatgtc cgttccgatt 1365241 ccgccgcttc agacatgatt aaagaagcgg taaaagcctt tggccggctt gacgcgctga 1365301 ttaacaacgc ggccggaaac tttatttgtc cggcagaaaa gctgacgccc aatggatgga 1365361 aagccgttat tgagattgtt ttaaacggca catttttttg cagccaagca gcggcaaggc 1365421 attggattga ccagaagcag cagggtgtca ttttaaatat ggcagccacg tacgcttggg 1365481 gagcgggagc gggggtcgtt cattccgctg cagccaaagc gggggtattg tcattgacaa 1365541 gaacgctggc cgttgaatgg gggagcaaat acggcattcg tacaaacgcg atagcccccg 1365601 gaccgattga acgaacaggc ggtgcggaga agctatttga atcggaaaaa gcgatggccc 1365661 gcacgatgaa cagtgtgccg ctcggccgat tgggcacacc ggaggaaatc gccgctttgg 1365721 cagcgttttt gctttctgat gaagcatcct atataaacgg ggattgtatc acaatggacg 1365781 gggggcaatg gctgaatcct tatccgtttt aatctgaata tttataagtg aatatttaag 1365841 ttattaagaa cttttatgtt cgaatgtaat acctccacaa ttaaccttct tcctatccaa 1365901 tttgataaca catagagctt tatttgttta tgaggtgttg tgtcatacgt aagccaccta 1365961 atatatgaaa ggtatatttt aaaaggggag acgaaatatg aagaacttag atttcaaata 1366021 aaacattcat ataattactt cgttaactaa aaagagaaat tataagaatg aaaggtttca 1366081 aggttacatc agattgggag gaaggtaata taatggacga gatggtatta ttaactcagg 1366141 aatggctcaa tgaaacgtac aaaggaaaaa gtggctacaa ttccattgag gaaaatggga 1366201 aaactggctg gaaaacaatg tatgcattaa ctagagcatt acaactagaa ttgggaatta 1366261 cacagacttc cgacagtttt ggtcctacaa ctttaagaaa gcttaaagaa ttaggcccga 1366321 tttctacgtc aactaattca aaaaaaaata ttgtgaaaat tattcaaggt gctctttatt 1366381 gtaaaggtta tggtccaggt ggattaacgg gtacatttgg tcagggaacg aaagaggcga 1366441 tagcagaaat gcaattgcat atggggcttt ctaaaacaga cggtgtagta acgcctaagg 1366501 tgtttaaagc tttattaaac atggactctt atatcctttt aaatggggcg tcagagaaag 1366561 ttcgttcaat acagcaatgg ctaaataata aatattacaa tagagagaat ttctacttta 1366621 tgccctgtga tggcctgtat tcaagggata ctcaaaagtc tcttgtttat gcaatacagt 1366681 acgaggaagg gttaagtgat agtatagcta atgggaattt tggaccaact actcaaagat 1366741 tgattcctgt attaagaatt ggagaaacag atgaaaaaaa cagttttatt catttatttc 1366801 aagctgctct aatctttaat ggctacaatg ttccttttga tggagtatac tctgaatctg 1366861 taagatcaaa agtaaaggct tttcagtctt ttgcaaaatt acaacagagt ggtactgccg 1366921 actttcaaac atgggcttca cttctagtaa gtactggaga ccccaatcga aaaggagttg 1366981 cttgtgactc aattactcaa attacatcgg acagggcgga gtcccttaag agggcaggtt 1367041 ataagattgt agggcggtat ctaacaaatg cgccggggag tacactaaat aaaaaaatac 1367101 aaccaggtga attagaaact atcttaaaat caggtttaaa tgtttttccg atttatcaaa 1367161 cctatggggg agcaacaaat tattttaata aagaacaagg aaagaaagat gcgtttgctg 1367221 cttataaagc agcaaaagaa tacgggttta aaaataacac tgtaatatac tttgcagtag 1367281 attatgatgc atatggtaac gatttaaaca acaatattat tccacacttc gaaggtataa 1367341 atgaaataat gaacggtttt ttaggttcaa cttacaaaat tggtatttat gcccctagga 1367401 atgtatgtac tatagtttct aaaaaaggtt tagcatttgc aagttttgta agtggtatgt 1367461 ctactggctt tagcggaaac ttaggatatc ctttgcctta caattgggcg tttgaccaaa 1367521 tttcaacaat tactgttgga aatggttctg gaatgattga aattgataat gatatttgtt 1367581 caggtttgga taatggagtt aataccataa atatagtgcc ttcagagaat aagaagtttt 1367641 ttgatcaaat tgatgtttta tatgaaactg ctgaaaaata tgctcaaatg caaagcgact 1367701 taaataatgg ggtaaaaaaa acacaattag ctaatgagtt ggttgcccag tatttaagaa 1367761 aggatgacta caaagggtgg aagtgggtcc ctaccgcagg ccagattgat cctatttatc 1367821 gtgaatgggc agtaaagcgc taggggaaga cctagtaaat ggaattgttg atcctatatc 1367881 aaaaactgtc ataggaacgc agcatcttat ggcaacttat aatgccatta tttatagtgg 1367941 tggttactct caaacactac gagattttgc tggttggact ggagatctat taacaacaat 1368001 acaggacatg aaattacacg ctcaagaatt taattcgcct tatgatgcgg ctatgaaaat 1368061 aataggtaat atgtatcaat ttagcctaga tgatttattt agtgatgtag atgcaattaa 1368121 tctagcgaat aaaacatcag ttggtgctaa tgcacaacct ctaaatatcg caattagaga 1368181 ttattatagt aataatgact gtatgaatag gttcactcaa tttgtaaata atagatttga 1368241 tggttcgtta gacaaaattt tctctgaagc agagtattat ttaaatacaa accttgaccc 1368301 agttgttgtt ccaattaggt tagcctttaa acgtgctttt gatgttgagg attatagtga 1368361 agagattgga aaaataacag cacaagcatt tagagatgtt atcgagaaaa aaatgatatc 1368421 tgaataaact gcaaaacaag cgaacgttaa aactggtcgt tcgcttgttt tattttctat 1368481 ttaaatttat gatataattt ttaaagatta aggagtgatt cattgaagaa attgttaaaa 1368541 aagttagttg tattattttt aagcagttta gttatcatct ttaatgtttg gtactttatt 1368601 atttgtgctt tttccccaga gtattatcaa aatacaaatc ttacttctaa tgaaataata 1368661 agatttgaaa aactatacca catagatttt cctgatgaaa caaaatttat taaagctaga 1368721 gagtatttgg ctgggcccgg aggagatacg tcagctgtat tatatgtgtc tctgccaacc 1368781 aagcgggtag aaaaagtttt atctgattac acgtatatga aaataaacta tactgacaat 1368841 gtcggttcaa tgtatggagt tgacgtttca aagagtgtcg ccggtttaac aactcttaca 1368901 tttggcactt acgataaaaa aggaactttc tataatatga aacatgatga tgattggatg 1368961 tataaaggca ctgactggaa tctttacttt tggacagctg ctagttataa tgctgttatt 1369021 tttgtatttg ttttggttat tgtgaaacaa atgaataaaa ttcttaatta accagtatgt 1369081 agattgataa tctcaaaaaa attttcctct tcttttaaca tactccatac gacctacttt 1369141 tccatactat gatttttttg aaatttgtgg tgtagttata attgtgcgta taatcagaca 1369201 aagatagaga agcaggtgat aacatgttgg atccacttga tattttaacg aacattgatg 1369261 atgtccttcc atattaccag gcgattttta gtgccgagga gcagaaggtt gtcggatatg 1369321 aggtgcttgg acgaattttg gcagattcag aaatccaaag tctcgggccc ttctttttag 1369381 atgcggggat acccgaagaa tataaattag aggttgataa cagaattatc cgccaggctc 1369441 ttgaccgctt tttagaggcg gattctgatc tgctgatttt tatgaatcag gatgccaatc 1369501 tgctgatgct ggatcatggt gaaagctttc tggagcttct gaaagaatat gaagcgaagg 1369561 gaatcgaact ccaccgtttt gtgcttgaaa ttacagagca caattttgaa ggggatattg 1369621 agcagctcta ccatatgctt gcatactatc gtacatacgg aattaaaatc gcagttgaca 1369681 acatcggaaa agaaagcagc aacttggaca gaatcgcgct gctctcacca gatctgttaa 1369741 aaatcgattt gcaggcgctg aaagtgtcac agccgtcacc gtcatatgag catgtgctgt 1369801 acagcatatc tttattagca agaaaaatcg gtgcggcgct gctgtatgaa gacattgagg 1369861 cgaacttcca gcttcagtac gcctggagaa acggaggccg ctattttcag ggctattact 1369921 tagtgtctcc atctgaaacg tttctagaga gagatgtatt gaaacaaaga cttaaaactg 1369981 aatttcacca atttatcaca catgagaaaa agaaactgga gaccgtctat gagcactctg 1370041 aacagtttta caaacgagtg catcaggctg tgacctcttt gagaaaaaac aatctgtctt 1370101 ctgatgatga ctttattaaa aagctggcgg aagagctgac agattgcagc ttcaggattt 1370161 acatgtgtga tgaagaaggc gatcagctga cgggaaatgt gtttaagcaa gatggagaat 1370221 ggatttatca gccggaatat gcggaaaaga actggagctg gcgcccttat tttctggaga 1370281 acattatgag aatgagaaat ctcagaaaag gttttttcag tgatctgtac agtgatttgg 1370341 aaacaggtga aatgatcaga acgttttcat atccgatgga tgatcagatg tatttattta 1370401 tagacttgcc ttattcttat ttatatgagc aggacggact gatttaacgg ctgaaaggcc 1370461 gtttttttta tgaaatgaaa aaaatatcaa aaaacgattg acattgatac tgagaatcat 1370521 tatcatttaa ttatagagag aagctactct ctgttcccca acccctctat cagatcaaga 1370581 tccgaaaaaa cttggcgcta cccccgccaa gttttttatt tgtcaaagca taggacaatc 1370641 caatgaaaca ataaacctaa ctagtggtaa acgtttaaca cggggagaaa cattgagtgc 1370701 cgaacacccc tgacactgct gcacgggtga ggaggaaaat tcgttctgaa atgattattt 1370761 cagttccgtt gtttacctct atccagcatg actcccattg attatggcca cgcgggactt 1370821 caccataaaa ttcaaaagaa ggttttgaca aagttgcaaa aaggcattct taatgctgcc 1370881 aaagattcga aaaaaattat aattatgtgc atgacattca aaaaaagcct caaactaaag 1370941 aaaaatagtt tttttcactt tttttctttg cttaaattca gcagtgaaaa tgccatcctg 1371001 tccgacttta tggtatgatg ctcaatagaa cttgtattat aataaatact tgttgatttg 1371061 aagttgcttt ttgaaaggag tcttttttta gaatgtcaca attaatgggt atcatcacac 1371121 ggctgcaaag tctgcaagaa acagcggaag cggctaacga gccaatgcag cgttatttcg 1371181 aagtgaatgg tgagaaaata tgcagtgtta aatatttcga aaaaaatcaa acgtttgaac 1371241 tgacggtttt ccaaaagggt gaaaaaccta acacatatcc gtttgataat atcgacatgg 1371301 tttccatcga aatctttgaa cttcttcagt aagattcctg aaataggggg aacaagcttc 1371361 cgcctttgca aaagtaatcg aaataaacgg taaggaacat acttgtttca tggttgtaaa 1371421 tccttgaaaa ggagtgtcgt gatggctgat tcttttctgt tttataatct ttcagaagca 1371481 cagatgacct ttcaagatgt gatggaacgg cttaaagcct ttgttcaaaa ggacccccgt 1371541 tcttcttatg tgttatcgat cggaaccgat tcacaggttt accgcgatta cacaaagttt 1371601 attaccgcat tgcatttgca tcgtacaggc aagggagctt ggggctgctt gaaaaatcat 1371661 acagtcgaca gacccataca tagccttcgg gagaagattt cgttagaaac ggcgtacagc 1371721 caagaaacgg ccgctcatat tcttgatgga cacttaatgg atattaccga tctgctcctg 1371781 ccctttaccg gtgagggggc ggatcttacc tttgaagttc acttggatat tgggaaaaaa 1371841 gggcttacaa aagatctgat ccaagaaatg actggacgta ttacctccat ggggattgag 1371901 gccaaaataa agccggattc atacactgcc ttcagctatg caaatcgttt cacaaaataa 1371961 tttggctgaa aaagccaagg taaatgtcga attatgcggt tgacgtttgt tatctgatta 1372021 cttattctag cggtagagct gaaagtaagt tgtcttgctt tcagaggtat tcagtataaa 1372081 acagggggcc tgattgcgaa tgagtcttat cggtgaacga tttacagaag aagaacaaaa 1372141 acttctgctg aatatcctga tcaaccatga gtatgccatc gagctattaa gcagtgagat 1372201 caacgatata gagacaggga ccaaaaacgt tgacggaacc acctacaaaa aacttgtaac 1372261 gctatacgac cgatttcgat ttgaaaatta atgggacacc ctataattga tactccacaa 1372321 agagtatctt ttttattgaa aggaaacttt tcgacaaata ctgataaagt ttatattatt 1372381 gcaatatagg gaatgtattg atgatgaaaa tgaaaagggg tcgaaaacat gataagctta 1372441 caatcagatc aacttcttga ggcaacagtc ggacaattta tgattgaggc ggacaaagta 1372501 gcgcacgtgc aagtcggaaa taaccttgag catgcattat tagtattgac aaaaaccgga 1372561 tacacagcca tcccggttct ggatccttcc taccgtttac atggcttaat cgggacaaat 1372621 atgatcatga acagtatttt tggacttgag cgaattgagt ttgaaaagct tgaccaaatc 1372681 actgttgagg aagtcatgct gaccgacatt ccgcgccttc atatcaatga tccgattatg 1372741 aagggattcg gcatggtcat taataacgga tttgtctgtg ttgaaaatga cgagcaggta 1372801 tttgaaggga tttttacgag aagagtcgtt ttaaaggaat tgaataagca tatacgctca 1372861 ttgaataagt aggctgtacg gtcctatttt tattatatag gcagagtgaa aaaagaaagc 1372921 gcatacataa tttaaacgag aatagggctt gaataagaaa ctaagatttt attagaatgg 1372981 gagataagaa aaacttattg ataacaaaaa ggaggacgac atgcagcttc aagagcttca 1373041 tatgctcgta gttttagctg aggaattaaa tatgagaaag gcggcagaac ggctttttgt 1373101 atctcagccg gctttatctc agcgcttaca aaccattgaa aaggcgtggg gaacaaaaat 1373161 ctttttaaga tctcaaaaag gattaacggt aacgcccgcc ggtgagaaaa tcattcagtt 1373221 tgcgaatgat gtgacattag agcaggaaag aataagagaa aatattgacg agcttgaagg 1373281 tgaaattcac ggcacattga agcttgccgt cgcctccata atcggtcagc attggctccc 1373341 taaagtcctg aagacgtatg tggaaaagta tccgaatgca aagatctcgc tcataaccgg 1373401 gtggagcagc gaaatgctga aaagcttgta tgaggatcag gttcatatcg gcattataag 1373461 aggcaaccct gagtggaagg ggcgcaaaga ttacttaatg acagatcatc tgtatttagt 1373521 ggatactgaa atttcctgca tcgaagatat tgcccataca gaacgtccgt ttatccagtt 1373581 taaaagtgac agcacttatt ttcaggaaat tcagcactgg tggcatcaaa aatttaaaac 1373641 gtcgccgaaa cagacgatat tggttgatca gattgaaacg tgcaaacaga tggcgctgca 1373701 cggaatcggt tatgccattt tgccgtctgt tacccttcaa aatgaagata aagtgaataa 1373761 aatgcctctt ttagacatga aagggcatcc gatcggtcgg gatacatggt tattaggtta 1373821 tgagcctgcc tttgaactga aacaagttca agcttttgta caagtgataa aggatatgct 1373881 ggatcaggaa aatccatttt aaagacagcg aggtgctgtc ttttttttat ttatctgttg 1373941 acaatgaaaa tcattatcat ttaaagtgat acatatgata ttgaaaatca ttatcaacta 1374001 atggggtgat aacatggcta aagccttgat tacatatgcc agcatgtcag gaaatacaga 1374061 agacattgcc ttcataataa aagatacgct tcaggaatat gagttggata tcgattgtgt 1374121 cgagataaat gatatggatg cgtcttgttt aacctcctat gattatgtac tgattggcac 1374181 ctatacatgg ggggacggcg atttgcccta cgaagcggag gattttttcg aagaggtcaa 1374241 acagattcag cttaatggtt taaaaacagc ctgcttcggg tctggcgatt attcttatcc 1374301 aaagttttgc gaagcggtga atttgttcaa tgtcatgctg caagaggcgg gagctgctgt 1374361 ttaccaggaa acactaaaaa ttgaattagc gcctgaaaca gatgaagatg tggaaagctg 1374421 ccgagcgttt gcgagaggtt ttcttgcatg ggcagattat atgaacaagg aaaaaatcca 1374481 tgtttcataa aggggcaacc gctgttacgg catcggcgtt ttctggatat tttgtggcgg 1374541 tacaaagaga aggcattttt cattactctt tggagcaggg ctggagaaag ctttttcgtt 1374601 tgaaaagtaa gatacactgt atcagctaca tagggcctta cttatttggc gttggtgaaa 1374661 agggaacagt cattcgttcg gctgatgaag ggaaaacctg gacgatgtcg agctttccga 1374721 caaatgcaac agtgtgggcg attaccggca gaaacaacgg gtttgtctgc gcccacggta 1374781 agcattgtat ttatgtatcg gatgattttg gtgtctcatg gcgcgtagcc aaaccttttg 1374841 ccgaatttca taatccccct gttatccggt cgttatgcct tcacgggggc aatctcttta 1374901 tcggcacgca aatacacgaa tattttggcg gcatttgggc ttacgacatt aagcgtgaca 1374961 ctgtccaagt tgtcaaaaaa gaaaaaaacc ggatgacggc atccatgctc gtgttcaatg 1375021 aaaattggct ggtggcggcg atgggttctg tgaaaggaaa gcacggtgct gtcactgtaa 1375081 ggaatctttt gaatggtgaa gaattcacca tacaatccag tatgatcaga aatgaagaat 1375141 catttcttga tctttcagag gatgatggca ttatatatgt cactacaaca caagatgaaa 1375201 atggtttttc gagaatttac caggttgatc tcgaagcccg gtcgttaaaa tggttcgata 1375261 ccattaaggg acatggatgg agagtggcca atcagaaaga gaatttcttt tgcgcaggct 1375321 tgtatgaatg taaatttgtc cagccgtacg aagtttcagc aatgattcat tagaggagga 1375381 acaaggaatt ggcgaagatt ttgctcgttt atgcaacaat gtcaggcaac actgaagcta 1375441 tggcagattt gattgaaaag gggcttcagg aggcgttagc agaagtagac cgtttcgaag 1375501 caatggatat tgatgatgcc cagctgttta ccgattatga ccatgtcata atgggaacct 1375561 acacgtgggg agacggagat ctgcctgatg aatttttaga tcttgttgaa gacatggagg 1375621 agattgattt ttccggcaaa acatgcgctg tattcggttc cggtgataca gcatatgaat 1375681 ttttctgcgg agcggttgat acgctagagg caaaaataaa agaacgcggt ggagacattg 1375741 tgctgccttc ggtaaaaatc gaaaataatc cagaaggtga agaagaggaa gaattaataa 1375801 acttcgggag acaattcgca aagaaaagcg ggtgcgctgt ctgatcactc actgggaact 1375861 gctaaaacgg ctgttccttt ttttcttgtc tttgtatctt tcctttgata cagtaatgag 1375921 gtagaaaatc aggaggagga ctatacatat gaaaatgatg gacgcaaatg aaattatttc 1375981 atttattcaa aatagtacaa aatctacacc tgtaaaggtt tacgtgaaag gtgagctgga 1376041 aggaatcaat ttcggtgaat ctgcgaaagc ttttatcaat ggaaacactg gtgtcgtttt 1376101 cggtgaatgg agcgaaatcc aaacagcaat cgaagaaaac caaagcaaaa tcgaagacta 1376161 tgtggttgaa aatgaccgcc gcaattctgc gatcccaatg cttgatctta aaaacatcaa 1376221 agcgcgtatc gagccgggtg cgatcatccg cgaccaagtt gaaatcggtg ataacgcagt 1376281 catcatgatg ggtgcttcta ttaatatcgg ttcagtcatc ggcgaaggca caatgattga 1376341 tatgaacgtt gtgcttggcg gacgagctac tgttggaaaa aactgccata tcggcgcggg 1376401 ttctgtactt gcgggcgtta ttgagccgcc atccgctaaa ccggttgtga ttgaagacga 1376461 cgtcgtaatc ggcgcaaatg ctgttgtgct tgaaggtgta acagtaggta aaggagctgt 1376521 tgttgctgcg ggagcgatcg tggtaaacga cgttgagcca tacactgtcg ttgcaggcac 1376581 accagctaaa aaaatcaaag acattgatga aaaaacaaaa ggcaaaactg aaatcaagca 1376641 ggaattacgc cagctgtaag gaaaagtttg ataaaaaagg cgtggataat atatccacgc 1376701 cttattcgta taggcaggag gaatagaaat gaagatagag gagctcatcg caattcgcag 1376761 agatctgcat cgtataccgg agcttggatt tcaggagttc aaaacccagc agtatttatt 1376821 aaatgtcttg gaacaatatc cgcaagacag aattgaaatt gagaaatggc gaacagggct 1376881 ttttgtaaaa gtgaacggga cggcgccgga aaaaatgctg gcatacagag cggatatcga 1376941 tgcgctttct atagaagagc aaactggtct tccattcgca tcagagcatc acggcaacat 1377001 gcacgcctgc ggtcacgatt tgcatatgac aattgcactc ggcattattg atcattttgt 1377061 tcaccaccca gtcaaacatg atttgctttt tctgtttcag ccggcagagg aagggcctgg 1377121 cggtgcggaa ccaatgcttg agagcgatgt attaaaaaaa tggcagcctg atttcatcac 1377181 tgcccttcat attgctccag agcttccggt aggcaccatt gcgacaaaaa gcggccttct 1377241 atttgcgaat acatcagagc tagtcatcga tctggaaggc aaagggggac atgcggcata 1377301 tccgcatttg gctgaggata tggttgtagc agcaagtaca cttgtcaccc agctgcaaac 1377361 gattatctct agaaacacag atccgctaga cagtgctgtt attacagttg gtaccattac 1377421 cggaggctcg gcacaaaata tcattgcaga aacggcccac ctggaaggca cgatccgcac 1377481 gctttctgaa gaatcgatga aacaagtaaa ggaacggatt gaagatgtag tgaaaggaat 1377541 cgaaatcgga ttccgctgca aaggaaaagt gacatatccg tctgtatatc accaagttta 1377601 caatacgagc ggattaacag aagaatttat gtcttttgtt gctgaacatc aactggcgac 1377661 agtaattgaa gcaaaagaag caatgactgg agaggatttt ggctatatgc tgaaaaaata 1377721 tcccggattc atgttctggc tcggcgctga ttctgaacat gggcttcatc atgctaagct 1377781 gaatcccgat gaaaatgcga tagaaacagc ggttcatgtc atgacaggtt atttttctgt 1377841 ttatgccaat taagtacaaa tgaaagaata aaattccata aaatgagcac tctagtaaac 1377901 ggaggtgttc aaaaatggct aaaaaaattg gaattgaaca atcgttatca gatgtagaag 1377961 ctgctttaaa agaaaaagga tatgacgttg taatgatgaa aagccctgct gatgctcaag 1378021 gctgtgactg ctgtgtcgta acaggtcttg ataataatgt gcaagggata gccgatacgg 1378081 taacacaagc acctgtcatt acagcttccg ggatgacggc tgaagaaatt tgtagcgaag 1378141 ttgagagcag aattcagtaa taaaaaaacc gaagcaaaaa gcttcggttc ttttatttat 1378201 tctgtttctt tagggaaagc gcggtcgaac gcgttcttta tttcttttct caacactcgt 1378261 tcgactcgcc actgttccat attttctgtt ttggcaatga ccctgattac aatttcagaa 1378321 gtccccagtt cttgaatccc gatgacattt gggccttctt ttatttgtgg aagagccgct 1378381 gccgtttcat cacaaacctg ctgtaaaata tgaatcattt catcaatatt tctttcagcc 1378441 ggcactttaa tgtcaacaag agcctgcatg gtaccacgag aatgattgct cacgtttgtg 1378501 atgtttctgt tggggatgta atgcagtgtt ccgtcaaagc tgcggatttg agttgtcctt 1378561 aagccaacct gctcgacaat tccgtcaaag gtggaaacgg taatataatc tccgacatcc 1378621 aattgtttct caagcaaaat aaaaaaacct gtcacgatat cactgacaag cccttgggcg 1378681 ccaaatccga cagccaggcc gacgattcct gcccccgcta aaagagcgct tggatcataa 1378741 tgaaacaaat ctagaaccat gacgaaaaat atgaaaatca atgtataagc aaatatgtta 1378801 agagtcaggc ttcggagcgt atgtgcacgt ccgatagaca agctattctg ctcctcgaat 1378861 tttgcaaaca gatgtttaat gattttcatg cctaatgatc gaacgataaa atagagcaat 1378921 atcataatgg cgagtttaat gagcagaaca ccggcatttg taatcagtcc cgcccaatca 1378981 tattgtttaa taaagtccat gttgagctcc ttttctaatt gattgctgca cattgagact 1379041 agttaccctg tacatgacca tgttaaacgt tttattcaaa aatgtcgaag ccaaagacat 1379101 acatgatttg ttaaaaattg actcaggaaa tctgctttta tataatggca ttgcaatata 1379161 actaaaaatg gttaatcacc ctttattttc atgcgatttt gacctttaag ccaaacaata 1379221 aattggaggg atacatatgg cagaacgtat ggtaggtaaa caagctcctc gttttgaaat 1379281 ggaagcagtc cttgcaagca aagaattcgg caaagtaagt cttgaggaaa acatgaaaaa 1379341 cgacaaatgg acagtgctgt tcttctatcc aatggacttc acttttgttt gtccgacaga 1379401 aattacagca atgtctgacc gctatgacga gttcgaagat cttgatgcag aagtcatcgg 1379461 ggtttcaact gataccatcc atactcattt agcttggatc aatacagacc gcaaagaaaa 1379521 cggtcttggc cagctgaaat acccgcttgc tgctgataca aaccatgagg tatcccggga 1379581 atatggcgtt ttaatcgaag aagaaggtgt ggctttgcgc ggattgttta ttattaatcc 1379641 tgaaggggag cttcaatatc aaactgtttt ccataacaac attgggcgtg atgttgatga 1379701 aacgcttcgt gttctccagg cgctgcaaac tggcggactc tgtccggcta actggaaacc 1379761 aggccaaaaa acactttaat tctttccaag aacgaaaagc ggtctagcat attcgttagg 1379821 cctctctttt aaaataggag ggaaaaagca atgaaattac gtcagcccat gccggaattg 1379881 acgggagaaa aagcttggtt aaatggtgaa gtgacgagag agcaattgat tggggaaaag 1379941 ccgacgctta ttcatttctg gtccatcagc tgccacttgt gcaaagaagc gatgccgcaa 1380001 gtgaatgaat ttcgtgataa atatcaagat cagctgaatg ttgtagctgt acacatgccc 1380061 cgttccgaag atgatcttga ccctggtaaa attaaagaaa cagctgctga acacgatatc 1380121 actcagccga tttttgttga cagtgaccat gctttaaccg atgcatttga aaatgaatat 1380181 gtacctgcat attatgtgtt tgataaaaca ggacagctcc gtcacttcca agccggcggg 1380241 agcggtatga aaatgcttga aaaacgtgtg aaccgcgttc tggctgaaac ggaataggta 1380301 tctgactaaa tagtatttcc taaaaacctg acctcatcag gttttttatt tgtgcaaaaa 1380361 gcaatggaag aagagtaaga agcttatttt tccaaatttg ggtataggaa ttgatgattt 1380421 gtttgattga tacgctaaaa aacacagcta atttttgatg tttttcctca attttagata 1380481 aatctcatat ctcataactc gaaaattgta gatattacac taaatttctt taaagaagta 1380541 agtaaaatat atattttcaa cattatacca aataaactag aaagcccctt aatcccttga 1380601 gaataaagga ctcttttgaa aaataaaaca ttttcagaaa ataaggaatt tttcatagag 1380661 taaatataat agtaaaatgc taaaataata gttgataaaa ttacttttgt aatctaatat 1380721 cttaattaaa gatgttaatt ttgatagggg gtacattgag gaatgtttaa tgaaagagaa 1380781 gctttgcgct tgcggttaga acaattaaat gaagctgaag tgaaagtcat tcgtgaatat 1380841 caaattgaac gtgataaaat atacgcaaaa ttaagagagc tggacagaaa tggaagccct 1380901 tccgaaatca aaaaggattt ccgttctgaa aaaaaacctg actctctgcc ggttctcgct 1380961 gagcttgcgg ctcaggaaat cagaagctat cagccgcaat cacagcagca gtctgttcag 1381021 cctcagcttc aatctatttc ctctcttcct gccggtatac cagacggaac aacacgaaga 1381081 agaagaggaa cggcaagacc gggatcaaaa gcagctaagc tgcgtgaagc tgctattaaa 1381141 acattaaaac gccacaacgc ggcgattaag agctcggagc ttcaaaaaga gattgaaaaa 1381201 gaaagcggtc ttgaaatccc taatatgaca acgtttatgc aaagcttaat taaaatgtac 1381261 ccggaagtga aaaagccata tcgcgggcag tacattttag agggtgaaat cgaatctgca 1381321 gaatcagcaa acgaataaat ataaagaaaa actgcttggc atcgctcaag cagttttttt 1381381 attgaggttt tttctgtgaa ggtttgtttt ctttttcaag attaagctta tacacccact 1381441 tttgataagg cttttcttca gcggctctgt ttttcagctc ttcgattgta tggctcttgg 1381501 cctggtctga tgattgggcg tgggcaagct gtttttgaag cacatgtatc tgtttggtga 1381561 catcttcaag gatagtctct acatgatttg gctgcgcgta ggccgctgga gcttcttctt 1381621 ccgttttttc tttttgtttc gtgccgccat caatatcggc aaaatgagaa gcaatccagg 1381681 catcgctttc atcaagttgc cgtttatacg atataatagt ttcgtgaaat aatttttctt 1381741 tcgttttttc tatgtctagc agtctttctt tcgtttctat gattcgatct ttcatatgat 1381801 caacttctat tttaatatgt tttagctgat attctttttc taccatttgc tcttttagac 1381861 gcccgttttc ggcttttatc aattcggctt gctgttttgc ctgaagcagt gcattttgtt 1381921 cctgctcaat tgaggcttga agttcgctga tccgtttatg aagattttta ttttcttctt 1381981 cgattttgac tttcgcaata tgaagtttat gtttttcttc gatttcggct ctgcgtttat 1382041 aggtttcagc agatagaagc tcctgcaaaa caacgatttt atcaagcagt tcagctctta 1382101 tttggtgcag ggtttggctg gtgtgggagg catgtttttc ttttgttgac atatgtgtta 1382161 attcggcaga cagctgctgg agtttttctt tcatatcggt attttctttg agcagtttgt 1382221 tatttttctg atgaaagtag cttgcttcaa gttcagaaat cagcttatgg caccttgaaa 1382281 gctcggattt taaataaagg ttctcctgag acacgtcgtg gaaaaaagga cctgatcttt 1382341 tcattcgaac catctccctc atgatgttaa cactacaata tgcaaatact gaacagctat 1382401 tcctctttaa taaacagaca agcagtagcg ttgagccttt gcttttgcta tgcttttaac 1382461 gaaactagag gtgagatgat atgaagcatg taaacgtact gctggcaggg ggagcctcac 1382521 gtcgctttgg agaaccgaag gcgtttgtca aatggaaggg caggatgctt tacgaatgcg 1382581 ctaaagaggc acttggagaa caaacggtta tcatcagccg tcccgaattt attgatagat 1382641 ttcaagaaaa cggtgaaaat gaagtgtatc aagatgctga gccatttcaa ggcatggggc 1382701 cattggctgg tatatatacc gcttttaaaa agacagacgg tgatctttat actgttcttt 1382761 cctgtgacac accgctgata caaagaagga cgatgctgga gctcaaacgt ctgatgattg 1382821 ccggtgcgga cgcggtagtc ccaatttcag acggacaagt gcagccattg attgcgattt 1382881 accacaaacg tatcatgcca gttctatacg atcagctttc tgagaagagg ttgagaatat 1382941 cagatttatt aggcagaatt tcggtttgtt acgtacaggc tgaaaatatc ggagcaaacc 1383001 cggcagagtt tatcaacatt aatacacgtg atgattttag ctgtttggaa gaaaaatcga 1383061 actccctcaa gcgggactga cggggcaata acatgataag atgacataaa agataaggag 1383121 aacaggtttg atggaggaac gttattcacg gcaaatcaga tttaagcaaa ttggggaaga 1383181 gggccagaaa agactggcag acagccatgt gctgattgtc ggagcgggag cgctcggcac 1383241 tgcaggagct gaagggcttt cgagagcggg agtcggtacg attaccatta ttgaccgtga 1383301 ctatgtggag tggagcaatc ttcaaaggca gcagctttat acagaaagcg atgccaaact 1383361 ccgcatgccg aaagccatgg ctgccaaaga gcatctatca gcgattaaca gcgagataca 1383421 tattgaggcg tatgttaccg aaggaacagc cgaaacgctt gagccgctga ttgaaaaagc 1383481 agatgtcgtg atcgacgcga cagataattt tgaaacccgc atgctgataa acgatcttgc 1383541 ccagaaaaca aagacacctt gggtctatgg cgcctgtgta agcagccagg gaatgttcat 1383601 gactgtcatt cccggagaaa ccccttgtct gtcttgtttg tttgagcaaa ttcctgtcgg 1383661 cggggcgacg tgtgatactg ccggcattat tccgcctgct gtgcatatcg tttcagcata 1383721 tcagcaggct gaggcattaa agctgttaac cggccaaaaa gaagcaatac agcgggggtt 1383781 tgtgacattt gatgtctgga acaattcgca tatgaagatt aacgttaatc atgtacgccg 1383841 tgaggaatgc ccatcttgcg gagctaatgc ggtatatcct tatcttcagg attggaacac 1383901 accaaaagct gctgtactat gcggccgtga tacagtgcag gtaaggtcag aatcattaaa 1383961 aagaatcccg aaacaggagc tcattaagcg gctgaaaaca atcggcaagg tcgaggctaa 1384021 tgcgtttttg ctgcatattt tttacgagga tttcagaatt gtcattttca atgacggacg 1384081 ggcactggtg catggaacaa atgatgtgaa agaagccaac tccgtgttgg caagagtgat 1384141 tggactgtaa caacaggagg ggtcagaatg ctggagaaaa gaacaccgat accggtagac 1384201 gaggcagttc ggcgtgtctg ccattttcaa aaacaaggtg aaacagaatg ggtggcgctt 1384261 gaagacagcc ttcatcggtt tttagccgaa gatataactg cggatcacca cgtacctgcg 1384321 tttgaccgtt cgccatacga tggttttgct gtcagagcgt gcgatacggc agaagcttca 1384381 cgtgaaaacc cagttcggtt tgaagttatt gaccatattg gagcgggagc agtatctgaa 1384441 aaagaacttg gcccgtttca ggccgtgcgg attatgactg gcgcgcaaat ccctgaaggg 1384501 gcagatgcag tcgtcatgat tgaactgact caagcctttg aggagaatgg gaagtcattt 1384561 atgtctttaa aacgccgctt tcagacgggg gataatattt caaaaacagg tgaggacgct 1384621 caaaaaggga gtgttttact gacaaagggc acccgggtga caccaggagt gacggctctt 1384681 ttggcaacat tcggatacgc atctgtgcct gtcgtgagaa agcctgtagt cgggattatc 1384741 gcaaccggta ccgaattgct gaatgtcagt gatccgctgg aaccgggaaa aatccgcaac 1384801 agcaatgcga gtatggtata tgcgcaagcg atagaagcag gcgcaacacc gctttattta 1384861 gggaaaatct ctgatgaact ggataaaagc tttgctgcag ttaaagaagc gatgaaaaag 1384921 gtggacttcc tgatcacaac tggcggtgtg tcagtcggtg actttgactt tttgcctgcg 1384981 atctatgaaa aactcggagc ggacgtgctg tttaataaag ttgccatgcg cccgggcagc 1385041 gtgacaacgg tggcgcatgc aaacgatatg ctgctgtttg gcctttcagg taatccgtcg 1385101 gcatgctatg tcggttttga actgtttgtc aaaccgataa tccagacatg gctgctcaat 1385161 gaaacaccgc attcaatttg tgcggaagct gttttgacca aggattttcc gaagccgaac 1385221 ccatttaccc gatttgttcg tgcgctcgtg caccatcagg aagggaagct gttggcgaca 1385281 cccgttggct tagataagtc gagctctgtc acatcacttg cagatgccaa tgcatttatt 1385341 atcctgccgg gcggtacgcg aggctacgaa tctggcagaa cggttcaagt gctgctcatc 1385401 agagaagaga atggaagtga atggccttgg tccgtccttt cccgatcgtc caagttgtag 1385461 gatttcaaaa cagcgggaaa acaacgttta ttgagcgcat tcttgaaaaa gcctctgaac 1385521 agggagtcca tttgggctgc ctgaagcacc atggtcacgg cggtgaaccg caaacgctca 1385581 cggaaggaaa agacacggac cgttacaagg cggcaggtgc tgatgtaaca gcggtagaag 1385641 gtgctggtgt gttacagctg actgcccgcc gcaattggga tttggcacgg ctgattgagt 1385701 tataccaatt tctcgaaaca gactgtcttc tgattgaagg ctttaaaaaa gccccttatc 1385761 ctaaagtggt tatcctaagt gaaaaggaag atctggaagc gctgcaagca gtaaatataa 1385821 tcgccatcat ctatagaaaa aaagagcata tgacagagca tcagggatta cccgtttttc 1385881 atgcggatga tccggttgcc gtggattttg tgctttcaca gctgaagggg gaatctgcat 1385941 aatggaacgg tttgagatta cgaaaacacc cattaatact gaaaacatca tcaaaaaagt 1386001 ggagaaacgg gaagcgggag ccattacaac atttattggt acggttcggg aatggacaaa 1386061 cggaaaaaga acggttcggc ttgaatatga ggcatatgaa ccgatggccg tgcaaatgct 1386121 tgctcaaatc ggcgctgaaa tcgaagaaaa atgggaaggt gcctcagctg cgatcacgca 1386181 ccgtataggt gtgctcgata tcggtgaagc agcggtagtg attgctgtat cttctcccca 1386241 tcgaaaagcc gcatatgaag ccaatgagta tgcgattgaa cgcattaaac agattgtgcc 1386301 gatttggaaa aaagaaattt gggaagacgg tgagcaatgg atcggcgacc agctagaaac 1386361 gacagcttat ccgaacggaa aaccagacct aagcgaggga gagcagcatg attaaaattc 1386421 ttttatttgc agggcttgct gaacaggccg gtacacaagc aatagaaata gatatggaac 1386481 aagcaaccac agatgaaata aaagcgagtc taaaagaaca atacggtctt gaatctattg 1386541 atacggctat gattgccgtt aacgaaagct atgtaaaaga aaatacctct gtatcttcgg 1386601 gtgacacggt agccatcata ccgccggtca gcgggggatg aaaaccggac ggcatttcag 1386661 ccgtccggtt tttctgtatt tcattggcat atccccaagt atcctcagca tacaatgatt 1386721 ttctgtaagc gtttattcta catatgttac tccctataaa gtaagagact cactccataa 1386781 ttagactgaa attttgaaaa ataatagaaa tttatttcgg gtatcgatat agtgaagatg 1386841 ataaatgttg gaaaggtgct ggatatggag acatttaaaa gattaaaaat gtattattgg 1386901 ccgtacagaa aagtgtttat gtggtcgctt ctagccatgc ttttgatgac tgcaattact 1386961 gtcgtttatc cgattatcct gcaaattacg attgatgaga tcgtactggg acggcagtat 1387021 cagcttgcgg cgtgggtcag cttaggattt attgcggtga tggttttgaa aggaatggct 1387081 accttttttc atcagtattt aggtgatatg ttcgggatca aatccgttta tcggctgaga 1387141 aatggtctgt atgaaaaact gcagcggctt tctttttctt actatgataa cgcgaaaaca 1387201 ggagatttga tgtccaggct gactgctgat gttgaagggc ttcgtttttt cttatcatac 1387261 ggtctcgctg agctcattcg cttcggcctg ctggtagcca tcagcctgtc ggttatgttt 1387321 tactattctg ttcctctcac gcttgtgaca atagctgttc tgccatttct cgcggttgcg 1387381 gtataccggt ttgacaaaag agtccatccc gccttcagag gcatccgcaa atcgtttgcg 1387441 aaactcaata caaaagttca ggaaaatatc agcggcatta atacggttaa atctctttcc 1387501 agggaagatt ttcagatcag cactttcaat aaagccaatg cagaatacag ggcgcagtat 1387561 ttacaaacat catccatttg gtctgcgtat ttccctttaa tggagttcat tggtaacact 1387621 tgtattgtag ctcttctctc atacggcggt tacttggtta tgcaaaatca gctcaatccc 1387681 ggcgagcttg ttgctttctt cagccttgtc aattatatga tgtggcccat tatgaactta 1387741 ggttttgtca tcaatatgtt ctctcaagca aaagcgtcag gggaacgcct gctcgacatt 1387801 ctggaaaaag aagaagacat tacagatcat cctcatgctt tgcataaaca aaaattaacc 1387861 ggagatgtcc atttcaaaaa tgtttctctt gcatacggaa aagaacaaac aaacgcgctg 1387921 tgcaatgtaa gctttgaggc aaacagcggg aaggtaatcg gactgttggg cccgacaggt 1387981 tcaggcaaaa gctcagtgac acagcttctc accagatttt acagtcctgt tggcggaatg 1388041 attaccattg atcacaaacc catcacagat tattcgttaa aaacccttcg ctccaatatc 1388101 ggggtcgtac ttcaagaatc cttcctgttt tcatctacga ttagatcaaa tatttcgtat 1388161 gggcggccgg atgcctcaat ggaagacgtc atcgaagcgg caaaaagggc gcaggctcat 1388221 aactttatta tggagcttcc tgatgggtat gacaccatgc tgggagagag gggaatgggg 1388281 ctttccggcg ggcagaaaca gcgtattgcc attgcgagag ccatctgctt gaacccgagc 1388341 attttaatat tggatgatgc cacaagcgca gtagatatgc aaacggagca cagcatacag 1388401 cttgccttaa aagaagtcat gaaaaaccgc acaaccttta tcgtcgctca ccgcatttct 1388461 tcactgaaac acgctgatga aattctcgtt tttaataaag gacgcattcg tgaaagggga 1388521 acacatcatg agcttcttga aaaaggcggc tactataaaa agatttacga tttgcaatac 1388581 cgtgatgtca aaatgattaa tgagccgcat gaggtcggat agggaggggc caaatgaaac 1388641 aagcgaaaaa acagggggtt ttagagcgtt tctattactc ttcagatgaa atcattgaaa 1388701 agccgtttaa ctgggctcaa atgtggcggc tgctgagcta tgtcaaacca tatcgaaaaa 1388761 caattttgcc gctttctttt ctcactgtat tgattggcac tgctgtgaag cttgtgatcc 1388821 ccattttgat cggcgtttat gttcttgatc aagcgattac agggagaaac tcggagctgc 1388881 tgattcagct catttttatt attagcggtt tatatgtcct caattacgcc gccaatgtgt 1388941 taagaatcag gtggatgaat cagcttggcc agcatgtcat ttacgatttg cgacagcatt 1389001 tatttaccca tgtgcagcgc ttatcccatc gattttttga tcagcggtcg gcgggatcga 1389061 tcttagtcag gatcatgaat gatattaact ctcttcagga gctctttaca agcggagtca 1389121 tcaatttgtt gaccgacttg ctgcttctgg ccggcgtgat tattattttg tttacgctga 1389181 gccctgagct gactatagcc atcatggtga cattgccgat tatgtttttt atttcaacaa 1389241 gtctcagaaa aaaaatacgc cgatcctggc aaacggtacg gctgaagcaa tcgaagctca 1389301 actctcatct aaacgaaagc attcagggca tccgggtcac gcaggcattt acgcaggaag 1389361 aagaaaacat ggcgtatttt gacggtgtca atcaggagaa ctacgaatca tggcgggaag 1389421 caactagaaa aaatgccatg ttccgtccgc ttgtagaaat gacgaatgcg attgggacgg 1389481 ctgtcttgat ttggtatgga gccacactca tcatgaatga aaccattacg attggcgtct 1389541 tcgtttcttt tgctttctat ctgggaatgt tttgggaacc tatttcgaga ctgggtcagg 1389601 tctataatca gctgttaatg gggatggcat catcagaacg gatttttgag tttctggacg 1389661 aacagccaaa tgtcaaggag aagccgaatg ccattcataa tgaaaagata aatggggaga 1389721 tcagttttga agaggttgaa ttttcgtatg atgaaaaacg aaaagccctt cacgccgttt 1389781 ctttctctat tcctgcggga tcgacgcttg cgcttgtcgg gcatacaggg agcgggaaga 1389841 cgacgattgc caatttaatc agccgttttt atgatgcggc cggaggcacc attaaaatag 1389901 acggtatacc gattaaggat ctttcccttg ccagtctgcg ctctcaaatc agcattgtcc 1389961 tgcaagatac atttattttc tccgggacca tcatggaaaa tattcgtttt ggaaggccaa 1390021 atgcttcgga tgaagaggtg atgaaagcgt cccaagcggt cggagcggat gagtttattt 1390081 ccgatttagc ggaaggatac gcaacagagg tagaggaaag gggcagcgta ctgtctgccg 1390141 gtcagcgcca gctcatttca tttgcaagag cattgctcgc cgatccggct attatcatcc 1390201 ttgacgaagc aacggcaagc attgatacag agacagaagt aaaaattcag caagcgttaa 1390261 aaacgcttct gaaagggcgt acagcagtga tgatcgctca cagattgtct acgatccgcg 1390321 acgccgaccg catcattgtt cttgatcacg gcaggaaaat agaagaaggg aaccatgatc 1390381 agctgctcgc taaaggaggc atttatgccg ggcttgtgaa agcgcaatac agcacagcga 1390441 tagaataata tgaaaagcct tcaatattga aggtttttgg aaatttatta gaaaaacatg 1390501 aaactttttg atatccttcc cgtactattt gttagatatt ctcaaggagg ttttgaaatg 1390561 gaaacgaatg tagaaaaaaa cagcggaacg gcgactgaaa agccttcact tttcggagta 1390621 atcacaagtc cgtccgttca atttgaaaga ataagagaaa ggccggctgt atggggaccg 1390681 cttttgattg ttgcagcaat tatcatcgtc ggtgccgtgc tgcaatcact cggtacggat 1390741 tatagtgagc ttttgaaaag ccaggatacg caagggctat ctgctgaaca aatggaaact 1390801 gtcgcaacaa taaccaaatt tggcggaatg gcaggcgcta ttatcggcgg tatcgcagca 1390861 ttatttattg cccctcttat ttattggctc tgtgtaaaag tatcaggcgg tgttacgaca 1390921 tataaaaaaa tgctttctct cagtctgttt gtctctttga ttagcagtct cggattattg 1390981 gttaatggaa tcgttgcttt tacgactgac gtgaatcctc tttacagcac gacgtcactc 1391041 gcagggatta tcccatctga cggggctctc gccagtgtgt taaatacctt tgaaattttc 1391101 agcatctgga gctttgtatt attagcaatc ggacttcaca aaacgggagg catctcaaaa 1391161 aaagccgggt ggatttcagc aatcattcta ttcggaattt tagttgtatt ttcgcttttt 1391221 tcaggtttaa tcaattctgt ggcgggtgca taagctcatg aaaaaagtct ggatcggaat 1391281 tggaatcgca gttatagtcg ctctttttgt tggaatcaat atataccggt ctgccgctcc 1391341 gacaagcggc agcgccggca aggaggtaca gacggggagc gttgaagaaa atgaaatctc 1391401 atcaacggtt atggttcctg gcacgctaaa attttcaaat gaacagtatg tcttttatga 1391461 agcggataaa gggacattag aagacattaa agtaaaggaa ggcgataaag ttaaaaaggg 1391521 cacggcttta gtcacctata caaatgagca gctgagcctg gaaaaagaac agaaccagtt 1391581 aacgtctgaa tccaaccggc ttcaaattga ccaaattcaa gaaaagttaa aagccttgga 1391641 cagcaaagaa agagaactgg aaaaacaggt aggaaagaaa gaagcagaaa aacaaatcga 1391701 atctgaacgg acagagcttc aaatgcagaa aaaaacagcg gagatcgaat taaaacaaac 1391761 cgagcttcag cggcagtcac ttgccaaccg ggtgtcagat ttagaagtga aaagcgaaat 1391821 tgaaggcacc gttatttctg tcaaccaaga agcggcatcc aaaaagtcag atattcaaga 1391881 gcctgtcata catatcggca acccaaaaga ccttgtcgtc tcagggaaat tgtctgaata 1391941 cgatacattg aaagtcaaaa aaggccagaa ggtcacactc acttcagatg taatacaggg 1392001 taaaacatgg aaaggcacgg tttccgcagt cgggcttgtt ccggatcagc aggagagcgc 1392061 tgcggcacaa ggaacagaac aggcggtcca atacccgctt caagtgaaaa taaaaggaaa 1392121 tcttccagaa ggaaagccag gctttaaatt tatcatgaat attgaaacag ataaacggaa 1392181 agcaaatacg cttccttcaa aggcagtcaa aaaagaagat gaccaatatt atgtgtatac 1392241 agtaaaagac ggaaaagcaa agcgagttga tgtcaaaatc ggcgaagtga cagatgacct 1392301 gacagaaatt aaagaggggc ttacccaaga tgatcaagtc attttgaatc catctgatca 1392361 ggtgactgac ggaatggaag tgaaatccta aatgattcag ctttctaatg tgcgaaaaag 1392421 ctaccagatc ggaaaggaaa cgtttgatgt tctccattct attgatttgg acattcatca 1392481 aggtgaatat gtctcgatta tggggccgtc aggatcagga aaatcgacga tcatgaatat 1392541 tatcggctgt cttgatcggc cgacttccgg tacatatcaa ttggacggcg aagacatttc 1392601 ttcatataaa gataaagaac tggcggcagt ccgtaaccgg tccatcggtt ttgtatttca 1392661 gcaatttcag cttcttccgc ggctgaacgc aaaaaaaaat gtcgagctgc cgatgattta 1392721 ttccgggata ggcaaaaagg aacgtcaaga gcgggctgag agagcattgg aaaaggtcgg 1392781 gttagccgat cgaatgctcc acatgcccaa cgagctgtcg ggcgggcaga agcagcgggt 1392841 ggcgattgcg agggcgatcg tgaatgagcc gaaattgatt ttagctgatg aaccgaccgg 1392901 cgcgctggat acgaaaacaa gcgaggcgat tatggatcag tttacagcat taaatgccga 1392961 gggaacgaca atcgttctgg ttactcacga gcctgaagta gcagattgca cgaatcggat 1393021 cgtcatggtg cgtgacggaa acattgttcc tgccagctcc ggacaaagga gtgtgggaga 1393081 atgagcctgt tggaaaacat cagaatggct ctaagctctg tccttgccca taaaatgcgt 1393141 tcgatcttaa cgatgctcgg cattatcatt ggtgtaggct ctgtcattgt tgtcgttgcg 1393201 gtaggacagg gcggcgagca aatgctgaag cagtcgatca gcggcccggg aaatactgtg 1393261 gagctgtact atatgcctag cgacgaggag cttgcaagca acccgaatgc cgcagctgaa 1393321 tctacgttta cagaaaacga tattaaaggt ttaaaaggaa tagaaggcat taaacaagtc 1393381 gttgcttcga cttctgaaag tatgaaagcg cgttatcacg aagaagaaac cgatgctacg 1393441 gttaacggaa taaatgatgg atacatgaat gtcaattctt tgaaaatcga aagcggcaga 1393501 acctttaccg acaatgactt tctcgcgggg aatagagtcg gaatcatctc tcaaaaaatg 1393561 gctaaagagc tgtttgataa aacctcccct ctaggtgaag ttgtctggat taacggacag 1393621 cccgttgaaa ttatcggcgt gctgaaaaaa gtaacaggct tgctttcttt cgatttaagt 1393681 gaaatgtatg tgccatttaa tatgatgaaa tcctcttttg gcacaagtga tttcagtaac 1393741 gtatcattgc aggtcgaatc agcagacgac ataaaatcgg ctggaaaaga agcggcacag 1393801 ctggtaaatg acaatcatgg cacagaggat tcgtatcaag tgatgaacat ggaagagatt 1393861 gcggccggaa ttggcaaagt aactgcaatt atgacgacga ttatcggctc aattgcaggt 1393921 atttcccttt tggtcggcgg aatcggtgtc atgaatatta tgctcgtatc agtcacagaa 1393981 cggacgcggg aaatcggaat cagaaaatca cttggtgcga cgaggggaca gattctgact 1394041 cagtttttaa ttgaatcagt cgtattgacg ctgattggcg gtctggtcgg gattggtatt 1394101 ggatacggag gggccgcgct tgtttcagcc attgcgggct ggccgtcact catatcctgg 1394161 caggttgtat gcgggggcgt gctgttcagt atgctcattg gtgttatttt cggcatgctt 1394221 cctgcaaata aagccgcaaa gcttgatccc attgaagcgc tgcgttatga gtagcctcat 1394281 gcaacatgca tgaggttttt ttatgtttag tgatttctac tatgaatata aaagactttt 1394341 ttcattaaaa taagaagaaa atgtcgtaca attgtcctta tttttgtcga atttacagtt 1394401 tacaaaccct atagacatac gttaatatgg agaaacgtga aagattttga tagttattga 1394461 atgaatttga atgattttag ttgcctaaac cgaaaatagc gtttacaatg aaattgtatt 1394521 caaaatgaat acgttttcat taggaggtga agcatgctaa ctcctgaacg gcatcaattg 1394581 attattgatc aaatagaaaa gcatgatgtg gtaaagattc aagagcttat aaatctgact 1394641 aatgcttctg aatcaacaat cagaagagat ttatcgaccc ttgaagaacg cggtttttta 1394701 aagcgcgttc atggtggagc ggccaagctt tccgatatca gacttgaacc cgatatgctt 1394761 gaaaaatcat ccaaaaacct tcacgataaa ctgaagattg ctgaaaaagc tgcttctctt 1394821 ttagaagaag gggattgcat ttaccttgat gcaggcacga cgacattgca catgattgat 1394881 tttatggata aaaccaaaga tattgtcgtt gtcacaaacg gggtaatgca tatcgatgca 1394941 ttaataagga aagaaatttc tttttatctg cttggaggat acgtaaagca cagaacgggc 1395001 gcgattattg gaggcgcttc attggttgcc atggaccagt acagatttga caagagtttt 1395061 ctggggacaa acggtgtcca tacagaggct ggatttacaa cgccggaccc tgatgaggcc 1395121 cttttaaaac agaaagcgat caaacaggca aaacacgctt acgtcttagc agacccttcg 1395181 aagttcggag aaatttcatt ttcggcattc gccggaatag gcgacgcaac aatcattacg 1395241 actgacgctg aagagcttac attcgataat taccaagaaa aaactgtcgt aaaggtagtg 1395301 aaaccatgat ttacactgta acacttaatc catctgtcga ttatatagtt cacgttgaag 1395361 attttactgt aggaggcctg aaccgttctt cgtatgatac caagtatcca gggggcaaag 1395421 gcatcaacgt atcgagactg ctgaaaagac accatgtggc gtctaaagcg ctcggattcg 1395481 tcggcggatt taccggagaa tatatcaaaa catttttacg ggaagaaaac ctggaaacag 1395541 ctttttctga agtaaaaggg gatacccgta tcaatgtaaa gctgaaaacg ggtgatgaaa 1395601 ctgaaattaa cgggcaggga ccgacaattt cggatgaaga tttcaaagcc tttttagaac 1395661 agttccaatc tttgcaagag ggagatatcg ttgttcttgc aggaagcatt ccatcttcac 1395721 tccctcacga tacttatgaa aaaatcgcag aggcctgcaa acagcagaac gcacgagttg 1395781 ttctggatat ctcaggcgag gctcttttga aagcaacaga aatgaaacca tttttgatga 1395841 agccaaatca tcatgagctt ggagaaatgt tcggcacggc cattacatct gttgaggaag 1395901 ccgttcctta tgggaaaaag cttgtagaac aaggcgctga acatgtaatc gtatcaatgg 1395961 ccggagacgg agcgcttctg tttacgaacg aagctgttta ttttgctaac gtgccaaagg 1396021 ggaaattggt aaactcagtc ggagcagggg attccgttgt tgcaggtttc cttgccggaa 1396081 tttccaaaca gctgccgctt gaagaagcat tccgcttagg agttacttca ggcagtgcta 1396141 ccgcgttctc tgaagaactt ggaacagaag aatttgtcca gcagcttctt cctgaagtta 1396201 aggtcacacg tctatagagg aggaaacaca agtgaaaata actgagcttt taacgaagca 1396261 tacgataaag cttaatattg agagcaaaga aaaagaaaat gttattgacg aaatggtcac 1396321 tgttcttgat aaggctggaa agttaaatga ccgacaagcc tataaagaag ccattttaaa 1396381 tcgcgaaagc caaagctcca cgggtatcgg tgaaggaatc gctatccccc atgcgaaaac 1396441 ggcaagcgtt atcaacccgg cgatcgcgtt cggacgttca aaagacggcg tcgattatga 1396501 atcattagac ggccagccgg ctcacttagt gttcatgatc gcggcgactg aaggcgcaaa 1396561 caacactcac cttgaagcat tgtcaagact ttcaacgctg ttaatgcgtg aagaaatccg 1396621 taagcagctc cttgaagctg agtctgaaga tgccatcatc gacattatta atcagcacga 1396681 taaagatgat gacgaagagg aagaggaaga agaagcggca ccagcacctg ccggaaaagg 1396741 gaaaatttta gcggttactg catgcccgac aggtattgcc catacattca tggctgcgga 1396801 tgcccttaaa gaaaaagcga aagagcttgg tgtggaaatt aaggtcgaaa caaatgggtc 1396861 aagcggcatt aagcacaagc tcactgccca agaaatcgaa gatgcacctg caatcattgt 1396921 cgcagcggac aagcaggttg aaatggaacg ttttaaaggc aagcgcgtac ttcaagttcc 1396981 tgtaacggcg ggtatcagac gtccgcaaga gcttatcgaa aaagcgatga atcaagatgc 1397041 gccgatttat caaggcagcg gcggcggttc agcagcttca aatgatgatg aagaagcgaa 1397101 aggcaagtct ggaagcggta tcggaaacac gttttataag cacctgatga gcggtgtcag 1397161 caacatgctt ccgttcgtag tcggcggcgg tattctcgtt gcgatttcat tcttctgggg 1397221 aattcactct gctgatccga atgatcctag ctacaacacg tttgcagcag cattaaactt 1397281 tatcggcggc gacaatgcat taaaactcat tgttgcagtt ctggccggtt tcattgcgat 1397341 gagtattgca gatcgtcctg gttttgcgcc tggtatggtc ggcggattta tggcaactca 1397401 agcgaatgct ggattcttag gcggcttaat tgccggattc cttgccggtt atgtcgtgat 1397461 tttactgaaa aaagtattta cgtttatccc tcagtcactt gatggattaa aacctgtttt 1397521 gatttacccg ctgttcggta tttttatcac tggcgtatta atgcaatttg tcgtcaatac 1397581 acctgtagcg gcatttatga atttcttaac aaactggctt gaaagccttg gtactggaaa 1397641 ccttgtgtta atgggtatta tcttgggcgg catgatggcg atcgatatgg gcggtccgct 1397701 taataaagca gcctttacgt tcggtatcgc catgatcgat gcaggcaact atgcgcctca 1397761 tgcagcaatc atggccggcg gtatggttcc tccgcttggt atcgcacttg caacaaccat 1397821 tttcagaaac aaattcactc agcgtgaccg tgaagctggt attacatgct atttcatggg 1397881 agctgctttc gtaacagagg gagcgatccc atttgctgcg gctgatccgc ttcgcgtcat 1397941 accagctgct gtagtcggtg cagctgttgc cggcggatta actgaattct tccgagtaac 1398001 gcttccggcg cctcatggag gagtattcgt agctttcatt acaaaccatc cgatgcttta 1398061 ccttttaagt atcgtgatcg gtgctgtcgt gatggcaatt atcctcggta tcgtcaaaaa 1398121 acctgttaca gaaaaataag aaaaaaagcg tccttggttc gaaaggacgc tttttcttat 1398181 ccggccggca gggagcgcgg ttaagttatg tattttattc ttttttatga taaagtaaaa 1398241 gaagagaaac aactgacata gcaattgtct aggaggaaac actttgaccg aggaaaaaaa 1398301 tacgaatact gagaaaacgg cgaagaaaaa aaccaatacg tacctggaat ggggtaaagc 1398361 gattgtcatc gctgttctgc tggctctcct gatccgtcac tttttgtttg aaccgtattt 1398421 agttgaaggt tcatctatgt atcccacatt acatgacgga gaaaggctgt ttgtgaataa 1398481 aacagtcaac tatatcggcg agctgaagcg cggagatatc gttattatca acggtgaaac 1398541 ttctaaaatc cattatgtaa aaagattgat cggaaagcct ggagaaaccg ttcaaatgaa 1398601 ggatgacacg ctttatataa acggtaaaaa agtagccgag ccttacttgt ctaaaaacaa 1398661 gaaggaagca gaaaaacttg gtgtcagtct gacaggagac tttggaccgg ttaaggttcc 1398721 gaaaggcaaa tactttgtca tgggagataa ccggctgaat tctatggaca gccgaaacgg 1398781 gctgggactg atcgcggaag atcgaattgt cggcacatcg aagtttgtct ttttcccgtt 1398841 taacgaaatg cgtcaaacaa aataaaaacg ccttgctggc ctaggacagc aggcgttttt 1398901 attttgaaaa agaagcgacc aatgcaatgc ataaaaccgt gatgaacact gaaccgataa 1398961 tagccagcac actgaagaaa aggtgaacct gtttgttctc ttttccgcgc ttttctaata 1399021 gccgtttaga aaaaatgtgc gaaaatatgt aaataagggc tatgcctata tataagccga 1399081 tatctttggc ggtaaagcct gttacggcaa ggtaaaagcc cgtaaaaaag atcagtaagc 1399141 aatattcagt aagtgttaaa agcctcaacg tgttcctcca tgagagtgtg taattttcca 1399201 ggcggatgca ttctctctct ttaattgtaa cacagctggc tggtttgggt gtataagtgt 1399261 tttctctctg ttttatcagg gaatcatttc tcttgccctg cattcatggt atacttttat 1399321 tgatgataga catgatggag gataataaat gattgctgta aataatgtaa gcttgcggtt 1399381 tgcggatcgc aagttatttg aagatgttaa tattaaattt accccaggca actgctatgg 1399441 gttaattggt gcaaacggtg ccggtaaatc aacgtttcta aaggtgctgt caggcgaaat 1399501 cgagcctcag acaggcgacg tgcatatgag tcctggcgag cgtcttgccg tcttgaagca 1399561 gaaccatttt gagtacgaag agtatgaagt gctgaaagtg gtcattatgg gccacaaacg 1399621 cctgtatgaa gtcatgcagg agaaagacgc tatttacatg aagcctgatt tctcagatga 1399681 ggatgggatt cgtgctgctg agctagaagg tgaattcgcg gaactgaacg gttgggaagc 1399741 ggaaagtgaa gctgcgatcc tgttaaaagg ccttggtatc tcagaagatc tgcacacaaa 1399801 aaagatggca gacctcggcg gttcggagaa ggtaaaagtt ctcttggcac aggcattatt 1399861 cggcaagccg gatgttctgc tgctcgatga gccgacgaac cacctggacc ttcaggcaat 1399921 tcagtggctt gaagagtttc tgattaactt tgaaaacaca gttattgtcg tatcccatga 1399981 ccgtcacttt ttaaataaag tatgtacgca cattgccgac cttgatttta acaaaattca 1400041 aatctatgtc ggaaactatg atttctggta cgagtcaagc cagctggcgt taaagctttc 1400101 tcaagaagcg aacaagaaaa aagaagagca gattaaacag cttcaagagt ttgtcgctag 1400161 attcagcgcc aatgcgtcta aatctaagca ggctacatca agaaagaaac ttctcgaaaa 1400221 aatcacgctg gatgatatta aaccgtcttc ccgccgctat ccttatgtta acttcacgcc 1400281 ggaacgggaa atcggaaatg atgttcttcg cgtggaaggc ttaacaaaaa caatcgatgg 1400341 cgtaaaggtg cttgacaatg tcagctttat tatgaatcga gaagataaaa ttgctttcac 1400401 tggccgaaat gaacttgctg ttactacgct gtttaaaatc atttccgggg aaatggaagc 1400461 tgacagcgga acgtttaaat ggggtgttac cacatctcaa gcgtattttc caaaagacaa 1400521 cagcgaatat ttcgaaggca gtgatctgaa ccttgtagac tggcttcgcc aatattctcc 1400581 gcacgaccaa agtgagagct ttttacgcgg tttcttagga cgcatgctgt tctctggaga 1400641 agaagtccac aaaaaagcaa atgtactttc cgggggagaa aaggtccgct gtatgctgtc 1400701 gaaagcgatg ctttctggcg ccaatatttt aattttggat gagccgacca accatttaga 1400761 cctagagtcc attacagcgc tcaataacgg cttaatcagc tttaaaggcg ctatgctgtt 1400821 tacttcccat gaccatcagt ttgtgcagac cattgccaac agaattatag aaattacacc 1400881 taacggcatc gtcgataagc aaatgagcta tgacgagttc cttgaaaatg ctgatgtgca 1400941 gaaaaaattg actgaactat acgccgaata aaaaagcaga gatttctctg ctttttttga 1401001 tacctaaatg tgaaaggaga tcacaacatg aaatttttgg ttgtcggagc aggtggagta 1401061 ggcgggtata ttggcggacg gctttcggag aaaggaaatg atgtgacatt tctcgtgcgc 1401121 caaaaacgag ctgagcagct taaaaaaacc gggcttgtca tccatagtga aaaagggaat 1401181 gtatcatttc agcccgaact aatcagtgcc ggagaaacag ggcaatttga tgtcgttatc 1401241 attgcttcta aagcatactc gcttggtcaa gtgatagagg atgtcaaacc atttatccat 1401301 caagaatctg tcattatccc ttttttaaat gggtaccgcc actatgagca gctatttgcg 1401361 gcattttcaa aagaacaggt gctgggcggc ctgtgtttta tagaaagtgc tttagacaac 1401421 aaaggagaaa ttcatcatac gagcgcatcg catcgttttg tatttggaga atggaacggc 1401481 gagcgtacgg agcggataag agcgcttgaa gaggcatttt caggtgtgaa ggctgaagtc 1401541 atcattagcg ggcatatcga gaaggacatt tggaaaaagt atctctttat tgcagcgcaa 1401601 gcggggatca caacgttatt tcaacgaccg cttggcccaa tcctcgccac agaagccgga 1401661 cgtcacacgg cccaaactct tattggggaa atttgcactg ttttacgaaa agaaggtgtt 1401721 ccggctgatc cggctcttga ggaagagagc tttcgtacga tgaccagcat gtcttaccat 1401781 atgaagtcct ccatgcttcg ggatatggaa aacggccaaa cgacagaagg cgaccacctg 1401841 catggatttt tgattgaaaa agcaaaacgt ttatctctcg ctgcaccagt attagaaacc 1401901 gtttatgcga atctgcaaat gtatgaagca gaaaaataaa aaaaggaggc ggaaaagcct 1401961 ccttttattt acttaaaaag cccaatttcc gtttctgaag ataggctctc ttttcccgtc 1402021 tgccgtaatt ccgtcaatat tcatatcctt agaaccgatc ataaagtcca cgtgtgtaat 1402081 gctttcattt aggccttctt tgacaagctc ttcacgagac atctgctttc cgccttcaat 1402141 attaaaggca taggcgcttc cgatcgccaa atgatttgac gcgttttcat caaacagcgt 1402201 gttatagaaa agaatgtttg attgtgatat aggcgaatcg taaggaacaa gtgccacttc 1402261 acctaaatag tgagaacctt catctgtttc caccagttct tttaaaatat cctcaccttt 1402321 ttcagcttta atgtcgacta tacggccatt ttcaaacgtc agggtgaaat tttcaataat 1402381 atttccgccg tagcttaatg gttttgtgct tgataccact ccgtcaaccc cgtctttttg 1402441 cggcagcgtg aacacttctt ctgtcggcat attggccata aactcatggc cactttcatt 1402501 cacgcttccc gcacctgccc aaacatgctt cctaggcagc ttaattgtta gatcagttcc 1402561 ttctgcttga taatgtaagg cagcgtaatg tctctcgttc aaatggtcaa ctttttcatg 1402621 aagattttgg tcatgattga tccacgcctg aaccgggttg tcttcattta cgcgcgtcgc 1402681 tttaaaaatt tcttcccaca gaaggtggat cgcttcctcc tctgatttgc caggaaacac 1402741 cttgtgagcc cagcctgctg atgccgcacc tacgacagtc cagctgactt tgtctgattg 1402801 aatatattgt ctgtatgtat gtaatgcttt gcctgctgct ttttggaatg ccgcaatccg 1402861 tttggaatct atacctttta gcaagtctgg gttcgacgac acaacagaaa tgaaagcagc 1402921 tccatttttg gcaagctctt ctctgccttt tgcttcccat tcaggatatt cttcaaatgc 1402981 ttcaaacggc gcaagttcgt attttaattt ggcgacttcg tcatcctgcc aattcacggt 1403041 gacgtttttt gcgccctttt catatgcgtg ttttacaatt aaacggacaa aatcccgaac 1403101 gtctgttgaa gcatttacga ctacatactg gcctttttgg acattaacgc cgacttctac 1403161 cgccagctgt gcatatgtat ttaatttctg tgaaaatgaa tccatgaatc attcctccaa 1403221 gcttttttct catcatatca aatatgatcc tataaaggaa agaaggagcc caaagtgaaa 1403281 aacccaaaac gacacgtctt gggttttttc aatattatgg atgattcagt tttacagtgc 1403341 cgcctgcagg cgaatggggc atatttgcca aagaaatgct catgcctcca agaataattc 1403401 cgcttaaaat ggctgcgatc gctactcttc ttcctaaatc tcttagcatc tgtttcctcc 1403461 ttaacgtttc tccatttccc acaatatgaa ggaagtgagg aaaaaagaag caagaaattt 1403521 gccgcgtgtg agaattttgc gggtaaagac tatttaattg ccttttgcag cttatcaatc 1403581 acttctaaag aacggcctgt gccgattgct acagattcaa gcgggttttg cgccacgtgt 1403641 acaggcacga caatctcttc tgtgagccat tctttaattc cattaaggag cgcgccgccg 1403701 cctgttaaaa taacgccgcg atcaacaata tctccgctca attcaggcgg acagtcctca 1403761 agtgtcgctc tgatggcttc aagaatatgc aggagggatt cacgcattgc atcttgaatt 1403821 tcgttggatt gaagcataat ggtttttgga agacctgtca cgaggtcacg tccccgaatt 1403881 tccattgcct ctggtatatg ttcaatcaga gcatggccaa tttccatttt tacctgctca 1403941 gctgtgcgtt cgccgatcag caaattgtat tttttacgga cgaaagaaac gatatcctca 1404001 tcaagctggt ctccgccgat cctgatagaa tggcaggaaa caacgccacc gaaggaaata 1404061 atagcgacct ctgtcgtccc tccgccgata tctactacca cattggcaac cggctcatca 1404121 accggtaaat ccgctccgat ggcggctgca actggctctt cgattaaatg aacgtttttc 1404181 gcgccgcaat ttttcaccgc atcactgatg gcgcggcgtt ctactgctgt tgagcctgat 1404241 ggtgtgcaaa cgactacgtt cggttttctg aacgacatgc cgatgctttt tgcggctttt 1404301 ttcataatgt gctttagcag gtcagttgtc atatcatagt ctgcgatcac gccatctttc 1404361 atcggtctga cagcgacaat ttttcccggt gttttaccga tcatgttttt cgcgtcagct 1404421 ccgattgcaa gcactgcttt tgtcgtcgta tccactgcga caacagatgg ttcatttagg 1404481 ataatccctt tatttttgct gtaaacaagt atattagctg ttcctaagtc aatcccgatt 1404541 tcagttgatt gaaacatgtt ttcacccaat ctctatccta atttaatatg attctacatt 1404601 taaagtttct cagaaatact gcgatttttg ggggtgtgcg tcggtaaaga aatgtttttg 1404661 taaaaaatca aggaactgtg taacagaagt aatacatttt tcggttttat ggaaaaaata 1404721 tcttgtaatt cttatagaaa gcgggaaact ttttcaaagt ttcattcgtc tacgatatat 1404781 tgaggtacat ccttaaaaca ttacatgaga aaagaaacat ttaaaggaag aagggttttt 1404841 atgaaatcaa taggtgttgt gagaaaagta gatgaattag gccgcattgt catgccgatt 1404901 gagttgagac gggcattgga tattgccata aaagacagca ttgagttttt tgttgacgga 1404961 gataaaatta tcttgaaaaa gtacaaacct catggcgttt gtttaatgac tggagaaatc 1405021 acttcagaaa ataaagaata cggcaacggt aaaattacgc taagccctga gggtgcacag 1405081 ctgcttctcg aagaaattca agccgcttta aaagaataaa attatgctaa aaaaggcgga 1405141 gtgatatcat ctccgccttt tttgcgtgcc aatttttgat taccgccgcc taagataaga 1405201 catcaagata tttggtaatg aatgatttgg gatactttac atattttact caattatttg 1405261 tcgaagaatg gtacaataag tagagaaaca caagcggcag gtggtcatat gagaaaatat 1405321 caagctcgta tcatttccat cattttggca atgattttta taatgttttg ggattattta 1405381 ttttatttta taggcaaaaa cccgattaat tggcctgttg atattgtgta tactgcagtc 1405441 acgctggtaa gtgtctggat gttggcttat tatattgatg agaaacagca gctggttaag 1405501 aaaatgaagg ataacgaatg gaagtataaa cagctttctg aagaaaaaaa ccgcatcatg 1405561 gataatttgc aggaaatcgt atttcaaacg aatgcaaaag gtgaaattac atatttaaac 1405621 caagcgtggg catctataac cgggttttca atcagtgaat gtatgggaac aatgtataac 1405681 gattacttca taaaagaaaa gcacgtagcc gaccacatta acacccaaat ccaaaacaaa 1405741 gcgtcttctg gcatgtttac ggcaaaatac gtgacaaaaa acggcacgat tttttgggga 1405801 gaagttcatt ataaacttta ctatgaccgg gatgaccaat ttacaggcag cctgggtaca 1405861 atgtcagata tcactgagcg gaaagaggct gaagatgagc tcattgagat taatgaacgg 1405921 ctggcgaggg aatcccagaa actatcaatc acaagtgaac ttgccgcagg tattgctcat 1405981 gaggtcagaa accctttaac atctgtcagc ggtttcctcc agattatgaa aacacaatat 1406041 ccggacagaa aagactattt tgacatcatc ttttcagaga ttaaaagaat cgatttagtg 1406101 ctcagcgagc tgctgctgct tgcaaaaccg caggcaatca catttaaaac acaccagctt 1406161 aatgagatct tgaaacaagt cacgacattg cttgatacca atgcaattct gtccaatatc 1406221 gtcatagaga aaaatttcaa agagacagat ggctgtatga ttaatggaga cgaaaatcag 1406281 ctgaagcagg tctttatcaa catcattaaa aacggaattg aggcaatgcc aaagggcggt 1406341 gtcgtaacca tttcaactgc taaaaccgcc tctcatgcag tgataagcgt aaaggatgaa 1406401 ggaaacggca tgccgcagga aaagctgaag cagattggca aaccttttta ttcaacaaaa 1406461 gaaaagggca ctggactggg acttcccatt tgtttgagaa tcctgaagga acatgacggg 1406521 gaattgaaaa tcgaaagtga agctggaaaa ggcagcgtct ttcaagtggt tttgccttta 1406581 aaatcagaca gctgagagga gaaaaataaa gtgaactcgc ttctgtttgt atacgggaca 1406641 ttaagaaagc atgaaaaaaa ccatcatttg ctggcacaat cggcatgtat caatgagcag 1406701 gcgagaacaa agggaagttt gtttgctgca aaagaggggc ccacagttgt tttcaatgat 1406761 gaagatgaag gctatatata tggcgaagta tatgaagcag atgaattgtg tatacataag 1406821 ctcgatcaat tttttcaagg atatcataaa caaacggtgt ttgtagaaac ggatgtcggg 1406881 attaaaattg cgcttattta ttttatgaac aaagacgggt gtgccggttt tacgaaaata 1406941 agcagcggcg actggaaaga acatcagatg atcagcaaat cgaaaaatcc catttattat 1407001 tttgcctatg gatcatgcat ggataatgcc cgctttcaaa aagcgggagt cgatcactat 1407061 tttcaagatc cagtaggaag agctgtttta aaaggataca caacccgctt cacgctaaaa 1407121 agggaagacg gttcaagagc ggacatgttg gaagacggag gaacaacaga aggcgtttta 1407181 taccgtatcc cttattctgc tctctcctat ctatataaaa gggagggcgt cgaatctctt 1407241 acgtatcggc cggcatttgt agacgttgaa gctggcggaa ggcactacaa agactgttta 1407301 acctttctcg tcctccaaaa agaagcggaa attgccccgc ctcagcacta tcagattgaa 1407361 atcgaacgcg gagcggagct gtatttgtcg cctgagttta ctgaaaagct caagcggcat 1407421 atgaattcgc tgccaaaagg ataacactgt aacaaaagaa tatgataaaa tttgatcaat 1407481 atcatgtcat ataaaggagc accacgatga aaaaagaatt tgcggtaatt gggctgggcc 1407541 gttttggtgg cagtatttgc aaagcattaa gcgaagaagg cgtcgaggtt atggcaatgg 1407601 atatcgatga agataaagtc aacgagtatg ccaagattgc atctcacgca gttatcggtg 1407661 attcgacaga cgaatctgtc ctgaaaaatt taggcctgcg aaattttgac cacgttattg 1407721 tagcaatcgg ggaaaatatt caagcgagta ttttaacgac actcattctg aaagaacttg 1407781 gcgtccatac gattacagtt aaagcgcaga acgattatca cgaaaaagtg ctgtctaaaa 1407841 ttggtgcgga tcacatcgtc cacccggaac gcgatatggc aaaacgaatt gcgcataata 1407901 tcgtgtccaa caatgtactt gactatttgg agctgtctga agagcatagt cttgttgaaa 1407961 tcgtagctaa cagccgcctg gctggaaata cgcttctcga tttagatatt cgcgcaaaat 1408021 acggtattaa catcgtagcc ataaaaaggg gcaaggaagt catcgtatca ccgcttgcaa 1408081 ccgaagtcat ccaccaagaa gatatactca ttgttattgg atcagttaca gacatctccc 1408141 gtttcgaaaa aagagttctt catacaaaat agcagccaaa taagccgtcc tcaaagggcg 1408201 gtttttcata ttatcagaat ataacaactt taatgaactg agcgtcaatt tcttaaaatt 1408261 tcattgacta agcacaggcg ttccgatagc atattgtacc atataataaa aaaaggaggg 1408321 gcctatttga ataaagaagc gctagtcaat aggctgaatg cttcagccaa aagacaaaaa 1408381 gctgatatcg tcattaaaaa cggaaaaatc atggacgtat ataatcaaga atggatatat 1408441 gaagatattg cgattacaga tggagttatt gtaggcctcg gtgagtatga aggcgaaaat 1408501 atcattgatg cagagggaca aatgattgtt ccgggtttta ttgatggaca tgtacatatt 1408561 gagtcgtcaa tggttacacc gattgagttc gctaaagcag tgttgcctca tggcgtgacg 1408621 acggttgtta cagatccgca tgagatcgcg aatgtgtctg gtgaaaaagg gattgagttt 1408681 atgcttgaac aagctcggca tacaccgctg aatatccatt ttatgcttcc ttccagtgtg 1408741 cctgccgcaa gttttgagcg atcaggcgca attctcaaag ctgccgatct caagcctttt 1408801 tatgaagaag aagaagtatt agggctggct gaagttatgg attatgtgtc ggttcagcag 1408861 gctgaaaaag acatggttca gaaactgctt gatgcccgtg tggcaggaaa aaggatagac 1408921 ggtcatttag ctggtttatc aacagacctc attaacattt acagaaccgc atttgtctta 1408981 aacgaccatg aagtaacatc gaaggaagaa gcccttgatc gtatcagaag gggcatgtat 1409041 gtcatgatgc gtgaaggatc agtcgccaaa aacacgctca atgtgctgcc ggcggtgaat 1409101 gaaaagaacg cacgccggtt ctttttctgt acggatgata agcatgtgga tgatttattg 1409161 tcagagggaa gtgtaaacca tcaggtgaaa atggcgattc aagccggact taatccgttt 1409221 ttagcctatc agctaggaag cctcaatgca gccgaatgct acggattaga tacaaaggga 1409281 gcgattgccc cgggttttga cgctgatttg ctttttgtat ctgatctgga aaatgtcact 1409341 gtcacaatga cgatggtaaa agggcagact gttgctgaag acagcaaagc ggtctatcag 1409401 gatcatgctt caactgcagc accagatcag gcactgcttg attctgttaa gcttgctgct 1409461 cctcttaaca aacaggattt tcatatgcca atcgattcag agcagcagat caatgtcatt 1409521 caaatcatac caaatcagct tgaaacacga ttagtacaag ttccggctcc tgttgcccgc 1409581 gaatttgagc ctgacactga gcttgatttg ttaaagattg cagttgtcga gcggcataaa 1409641 ggattaaaag aaaccggact tggtgttgtg aaaggttttg gattcaagag cggagcgatt 1409701 gccacaacca tttcacacga ctcccataat attattgccg tcggaacgaa tgatgaggat 1409761 atcgcggcgg cagttaataa gctgcaggaa attggcggag gattaacaat tataaaaaat 1409821 ggggaagagc tccattcagt accgctgccg attgcagggt tattatccga ccaatctgca 1409881 gagcaagtga atcaaagctt gctgacgctt catgataaat tgtcgttaat cggtttcaca 1409941 ggcggattta atccattttt gacattgtcg tttttagcgt tgcctgtcat tcctgatatt 1410001 aaaatgacga ctacgggatt attcgatgta aaatcatttc aacacatatc actgcaataa 1410061 aaagaggcac tcccttaggg agtgcctctt tttttaaacc tccataatga tcggcaggat 1410121 cattggacgg cgctttgttt tttcgtacaa gaaaggtgca agcgtgtctg taatttcgtt 1410181 tttgatttca gaccattgag tcgtttttcg ttccattact ttttgtaagt gatttgaaat 1410241 gagctcttga gcgtcgttga tcaagtcacc agattctctc atgtacacaa atcctctgga 1410301 aatcaaatca ggacccgctg aaatcttgaa gtcgtccatg tcaatgctga caacaacgat 1410361 gacaagtcct tcttcagaga gaattctgcg atcacgaagt acgatattgc caatatcacc 1410421 gataccgctt ccgtcaatgt acactgaacc ggacgggatt tttcctgcaa ctgaagcctc 1410481 atcgccttta agtgctaata cttcaccatt atccatgata aagcagtttt cctctgggat 1410541 gccacaatct gttgcaagtt tgacatgcat cttttgcatt ctgtactcac cgtgaatcgg 1410601 catgaagaat ttaggcttga ttaaacgaag catcagcttc tgttcttcct gtccgccgtg 1410661 accggatgta tggatatcgt taagagggcc gtgaataacc tcagcacccg cacgatacag 1410721 ctggttgatt gttcgactca cgctgattgt gttgcctggg ataggggatg aagaaaatac 1410781 gactgtatcc ccaggattga ttgaaatttg gcggtgtgtg ccgtttgcaa ttcttgataa 1410841 cgccgccatt ggttcccctt ggcttcctgt acataaaatt gttactttat tagcaggcat 1410901 acgattgatt tcgttatgct caataaacgt atttttagga cagttaatat aaccgagtgt 1410961 ctgtccaatt tcgatagccg attccatact gcgtccaaat acggcaactt ttcttccatt 1411021 ttgtacagca gcttcaatta cctgctgcaa gcggtgaata ttcgacgcaa atgtggcgaa 1411081 gataattcgg ccgtccacct tgcggaaaat gtcatgaatg ctttctccta cacggcgctc 1411141 agacatggta aactccggat tttcactgtt tgtgctgtct gaaagaaggc acaaaacgcc 1411201 ttctttaccg atttcggcca ttttcgttaa gtttgccggc tcgccgactg gagtaaagtc 1411261 gaatttgaaa tccccagtat gtacgatgtt tccgggcggc gtttttacaa caatgccgta 1411321 ggaatccgga atactgtgtg ttgttctgaa gaatgacaca gccgttttgc ggaactttac 1411381 aatatcatcc tcgccgataa tgttcagttt cgtctgtctc aataatccat gctcttcaag 1411441 tttattccga agtaagccga tcgcgagttt tccgccgtat acaggaatat tcacttgtct 1411501 gagcaggtat ggaataccgc cgatgtggtc ttcgtgcccg tgggtgataa aaagcccttt 1411561 aattttatct tcgtttttga ctaaatacgt ataatcaggg atgacgtagt caattccgag 1411621 cagttcgtcc tcgggaaact tgatccccgc atcaatcagt acaatttcat cctggaattg 1411681 caccgcgtac gtatttttac cgatttcgcc caaacctccg agggcgaaaa cagcagtctg 1411741 atcatttttt acaaatttca taccgctcat aactccaata ctttaaaatt ttcgctctgt 1411801 tgttcatatt ctaagaatgc accatcaaca ggtgtaataa actcaatatt aaatttcttt 1411861 tctttcagct ttgttctgac gtcacgctca gatacgcctt caatataaag tgaatctgtc 1411921 ttttcccgaa caggtacttc gtcagccttc tcttgataaa ataccttata aatcattcca 1411981 aatctctcct taaatgccgt atgttagact cgctcattct attatattcg aaaacggaat 1412041 ataaggaaag ccttgagcaa aataaggatc tctcaaaaag tgaaagatcc cttgtcaggc 1412101 aattgctttc ttacggagca ttccgttcca ttgtcttctg agtttctttc ttaatttacg 1412161 cagcattagc cagtccctcc tttaatgaaa aatttgtccc agagttcttt tatacaaata 1412221 gtatacggag attgaggaag acttttcgtg gttattaatg gaatttaata tgatttttga 1412281 acgaaattgt ttgctgaatg acaatctttt tgtatgatga gggtgggaat tgcagaccaa 1412341 gacgataaag gggaagttgc gatggattct aaattaatct tttttgatat tgacggcaca 1412401 atatatgatc atgataagaa tataccggaa agtacgagaa aaaccgtggc ggagcttcag 1412461 cgccaagggc atcatgtgtt tattgccagc ggccggtctc catttttggt taagccgatt 1412521 ttggaggagc tgggcatcca ctcatttatt tcctacaatg gacagtttgt tgtctttgaa 1412581 aatcaagtga tttataaaaa tccgctgcct gaaaatgcaa tcaggcgatt attaaagcag 1412641 gcggatgaag gcaagcatcc tgttgtgttt atggctgagg acacgatgaa agcgactgtt 1412701 gcggatcacc cccatgttct cgagggaatc ggcagcctta aaacagatta tccagagacc 1412761 gatgaccttt tttatgaagg aaaagaaatt tttcagcttc ttttattttg tcaggatgaa 1412821 gaagaaaaag cttatgccgc ttttcctgag tttgatctag ttcgctggca tgagctatcg 1412881 actgatgttc tgccgcacgg aggttcgaag gcagaaggaa tcaaaaaagt gattgagcgt 1412941 cttccgtttg atatcggcga tacatatgct ttcggcgacg gattaaatga tttgcaaatg 1413001 attgaatacg ttgggacagg cgttgctatg ggaaatgctg ttcccgaact gaaagaaatc 1413061 gcggactttg taacaaaacc ggtggacgag gatggaattg catacgctgt caaagaattg 1413121 ggccttttaa aataaagaaa cggctggcat tgtgccagcc gttttctctt ttagcgctca 1413181 attgcgattg cattttcagg ttctttgaaa ggattttcct tatcaatatg atcatagaac 1413241 ataacgccgt tcaaatgatc gatctcatgc tgaaacacaa tagccggaaa tccttttaaa 1413301 cgaatatcaa tattttcgcc ttctagtgtt gttcctttta ctctgatgcg agcatagcgg 1413361 ggaacataac cgggaatcgc ttcatccaca gagaggcagc cctcgccgct tgttaagtag 1413421 cttttttcaa ctgaatggct gacgatctta ggattaaaca gagcatagct gtataattta 1413481 ccggaagcat cttccgcatg aacggcgatc attcgttttt tgatattaat ttgaggagct 1413541 gcgagtccta cgccagggcg cagcttgtat ttttcggcta attctggatt ttggctgttt 1413601 ttaacaaatt cgatcatgtc ggccagctgc tgtttttctg catcagttgg aggcagctca 1413661 acaggttcgg cagtctctct gagggctgga tggccgtcac gtacgatgtt ttccatagta 1413721 atcaagaaac ttcactccta aagcttaata tgtaaattat atcggatttc ttcacaaagg 1413781 tgcaacgaaa cgaatgacca gccgtatatg gctggtcaat ttcatgctgt gtggttagca 1413841 acagcctcca cctaaataag cagctccgac aatgattaac agaatgaata aaacaacgat 1413901 tagcgcaaag gtgcggccgt agccatatcc gcagccacca tatccgtaac caccataact 1413961 gcagcagcct ccgccgtaac catatccata catattacat aacctcctct tttaattacg 1414021 ccagagcctt tataagtagg catagcgtct aatataacct atgtaaaaac aaaaaagttg 1414081 tatggtcatc tgtcctgatt tttcactttt ttgatttaat ttcagtattg catttataca 1414141 gcacggctat tgccaaatgt ccccatggat tctatagtag aaattgtcaa gattggggga 1414201 tttaacgtga aagacgctat aaaacggcgg cctggaatca agatcggagc tttttgtgcc 1414261 atggcactga tattaacagg atgcatggga caggacccgg ttgattcact tcatcattca 1414321 ttagaaaaag ccgcggaatc ggaaaagccg tttcaagaag aacaaaacac actcaaagaa 1414381 ttagaggcca aagaaaatca gctttacgat agtgttatga agctcaatat ggatgattat 1414441 aaaaaaattg ttgctttatc taataaggcg cttgaaaatg tcagcaagcg cgaagaacac 1414501 ctaaagcttg aaaatgacag catgaaaaaa tcggaaacag aatttgagga agcaaaaacg 1414561 tcagcggaac atattaagga aaaagacata aaagaaaagg ccgatgccgc agcaaaccat 1414621 atggagaaaa gatatacatc atatggcact atgtataaag agtataaaaa agcgcttgag 1414681 cttaataaaa aactgtatat gcagctgaaa gacaaagatt tgacaagaga tgatctggat 1414741 cagcagatcg ataaagtcaa tgcttcttat gaaaagatcc ttaaatatag cggagaattt 1414801 aatgaacaaa ccgaaaaata taataaagcc cgggaagatt tatatgatgc tgcaggctat 1414861 cgtgtgaaaa agagctgact cgatcagctc tttttttgaa tgaaatgcga ttcggatttc 1414921 gttcaaaatt ttcatttcta ttgtagtaca gcatagtaag gtatactagt acagttttgg 1414981 gtgcggttgg catctgtttt tttgatgaaa atgtaaagcg aatacattta ttgaaaatca 1415041 gcgatgaaaa cgattgacgg ttcttcttta tttggtgtaa actaatccat gttaagcggt 1415101 gttgtattag ttttttacaa cttcgaaata atacagttca aagcagagtg taactatcct 1415161 acataaaagg ttttggcaaa ctggggatcg gctaaaatat aatacgactt actgctgata 1415221 ctttagggta ccctaagttt gtatgtataa aaggaatgca cgtctaatga ctgtttaaaa 1415281 gaaaggaaga ggtgacttag tatggctgca aaaacgaaaa aagctatcgt tgacagtaag 1415341 aagcaatttg atgccattaa aaagcagttc gaaacgttcc aaattttaaa tgaaaaggga 1415401 gaagtcgtga atgaagcggc gatgcctgat ttaactgatg atcaattaaa agagctaatg 1415461 cgccgcatgg tatttacgcg tgtgcttgac caacgctcta tctcattaaa ccgtcaagga 1415521 cgtctcggat tttacgctcc tactgcgggt caagaagctt ctcagattgc aacgcatttc 1415581 gcgcttgaaa aagaagactt tgttcttcct ggataccgtg atgtgcctca gttaatttgg 1415641 cacggccttc cattatatca agcgtttctt ttctctcgcg gacatttcag aggaaaccaa 1415701 atgcctgatg atgtgaatgc cctttctcca caaatcatta tcggtgctca atacattcaa 1415761 actgccggtg ttgcgctagg tcttaaaaaa cgcggtaaga aagctgtcgc aatcacttac 1415821 actggtgacg gcggagcttc tcaaggggac ttctacgaag gaattaactt tgccggagct 1415881 tataaagcac ctgcaatctt cgtggtgcaa aacaaccgtt acgcgatttc aactcctgtt 1415941 gaaaaacaat ctgcagctga aacaattgca caaaaagctg tagctgccgg tattgtcggc 1416001 gtacaagtag acggaatgga tccgcttgct gtatacgcag caactgctga agcacgcgag 1416061 cgcgcaatca acggcgaagg tccaacacta attgaaacac ttacattccg ttatggcccg 1416121 cacacaatgg ctggtgacga tcctactaaa tatcgtacaa aagaaatcga aaatgagtgg 1416181 gaacaaaaag atccgcttgt acgtttccgt gcgttccttg aaaacaaagg cttatggtct 1416241 gaagaagaag aagcaaaagt gattgaggat gcgaaagaag aaattaagca agcgatcaaa 1416301 aaagctgatg ctgaaccgaa gcaaaaagta actgatttaa tgaaaatcat gtacgaaaaa 1416361 atgcctcaca accttgagga gcaatttgaa atttatacac agaaggagtc gaagtaagcc 1416421 atggcgcaaa tgacaatgat tcaagcaatc acggatgcgt tacgcacaga actgaaaaat 1416481 gacgaaaatg tcttagtttt cggagaagac gttggtgtaa acggcggcgt attccgtgcg 1416541 acagaaggat tgcaaaaaga attcggtgaa gaccgtgtgt ttgacacgcc acttgctgaa 1416601 tctggtatcg gcggtcttgc ccttggttta ggcttaaacg gcttccgtcc ggtaatggaa 1416661 atccaattct tcggatttgt ttatgaagta atggattcag tttctggcca aatggctcgt 1416721 atgcgctacc gttctggcgg acgctggact tcacctgtaa caattcgttc tccattcggc 1416781 ggcggtgttc atactcctga acttcacgct gacagcttgg aaggtcttgt tgcacaacag 1416841 cctggtatca aagttgttat tccatcaact ccttacgatg ccaaaggact tttaatttct 1416901 gcgatcagag acaatgatcc tgttgtcttc ttagagcata tgaagcttta ccgttctttc 1416961 cgtcaggaag ttcctgaaga agaatacaca attgagcttg gaaaagctga cgtgaaacgt 1417021 gaaggtactg atctttcaat catcacttac ggcgcaatgg ttcatgaatc attaaaagct 1417081 gctgatgagc ttgaaaaaga cggcatttct gctgaagttg tcgaccttcg tacagtaagc 1417141 ccacttgata tcgatacaat tatcgcctct gtagaaaaaa caggacgcgc gattgtcgtt 1417201 caagaggcac aaaaacaagc cggtattgct gcaaacgtag tagcagaaat taatgaccgt 1417261 gcgatcctga gcttggaagc acctgtactt cgcgttgcag cgccagatac agtatttcct 1417321 ttctctcaag cggagagcgt atggcttcca aaccataaag acgttcttga aacagcaaga 1417381 aaagtgcttg aattttaatc aaactgcata atcgagaggg aagatgaacg ttttccctct 1417441 attatatatc tgttttcaat gcttacgatg taaactttaa aattgcttaa tcaaactagg 1417501 aggtcgagaa ctgtggcatt tgaatttaaa cttccagata tcggggaagg tatccacgaa 1417561 ggcgaaatcg taaaatggtt tgtcaagcct aacgacgagg tagacgaaga tgatgtactg 1417621 gctgaagtcc aaaatgataa agcagtagta gaaattcctt cacctgttaa aggaaaagta 1417681 ttagaattaa aagttgaaga gggaacggtt gcaactgttg gacaaacgat tattacgttt 1417741 gatgcacctg gttacgaaga tcttcaattt aaaggcagcg acgagtctga cgatgcgaaa 1417801 actgaagcac aagttcagtc aactgcagaa gctggacaag acgttgcgaa agaagagcaa 1417861 gctcaagagc ctgcaaaagc tactggcgca ggacagcagg atcaagctga agttgacccg 1417921 aacaaacgcg tgatcgctat gccttccgta cgtaaatatg cacgtgaaaa aggtgtagac 1417981 atccgtaagg ttactggttc aggcaacaac ggacgtgttg taaaagaaga tatcgacagc 1418041 tttgtaaacg gaggagcgca agaagctgca ccgcaagaaa cagctgcacc acaagaaaca 1418101 gctgctaaac cggctgctgc accagctcca gagggcgaat tcccagaaac acgcgaaaaa 1418161 atgagcggta tccgtaaagc aattgcaaaa gcgatggtta actctaaaca cactgctcct 1418221 cacgtaacgt taatggacga agtggacgta acaaaccttg ttgcacatcg taaacagttc 1418281 aaacaggttg ctgctgatca aggaatcaag ctgacttact tgccttacgt tgtaaaagct 1418341 cttacatctg cactgaaaaa attccctgtt ttaaacacgt caattgacga taaaacagat 1418401 gaagtcatcc aaaaacatta cttcaacatc ggtatcgctg ctgacactga aaaaggcttg 1418461 cttgtaccgg ttgtgaaaaa tgcagatcgt aaatctgtct ttgaaatttc tgatgaaatc 1418521 aatggccttg caacaaaagc tcgtgaaggc aagcttgctc cagctgaaat gaaaggcgca 1418581 tcttgcacaa ttacaaacat cggttctgcc ggcggacaat ggttcactcc ggttatcaac 1418641 catccagaag ttgcgattct tggtatcgga cgcattgcag aaaaagcgat tgttcgtgat 1418701 ggcgaaatcg tagcagctcc agtcttagct ctttctctca gcttcgacca ccgtatgatc 1418761 gacggagcaa ctgcgcaaaa tgcattaaat cacatcaagc gtttactgaa cgatccacaa 1418821 ttaattttaa tggaggcgta atgttatggt agtaggagat ttccctattg aaacagatac 1418881 tcttgtaatt ggtgcgggac ctggcggcta tgtagctgcc atccgcgctg cacagcttgg 1418941 acaaaaagta acagtcgttg aaaaagcaac tcttggaggc gtttgtctga acgttggatg 1419001 tatcccttca aaagcgctga tcaatgcagg tcaccgttat gagaatgcaa aacattctga 1419061 tgacatggga atcactgctg agaatgtaac agttgatttc acaaaagttc aagaatggaa 1419121 agcttctgtt gtcaacaagc ttactggcgg tgtagcaggt cttcttaaag gcaacaaagt 1419181 agatgttgta aaaggtgaag cttactttgt agacagcaat tcagttcgtg ttatggatga 1419241 gaactctgct caaacataca cgtttaaaaa cgcaatcatt gctactggtt ctcgtcctat 1419301 cgaattgcca aacttcaaat atagtgagcg tgtcctgaat tcaactggcg ctttggctct 1419361 taaagaaatt cctaaaaagc tcgttgttat cggcggcgga tacatcggaa ctgaacttgg 1419421 aactgcgtat gctaacttcg gtactgaact tgttattctt gaaggcggag atgaaattct 1419481 tcctggcttc gaaaaacaaa tgagttctct cgttacacgc agactgaaga aaaaaggcaa 1419541 cgttgaaatc catacaaacg cgatggctaa aggcgttgaa gaaagaccag acggcgtaac 1419601 agttactttc gaagtaaaag gcgaagaaaa aactgttgat gctgattacg tattgattac 1419661 agtaggacgc cgtccaaaca ctgatgagct tggtcttgag caagtcggta tcgaaatgac 1419721 ggaccgcggt atcgtgaaaa ctgacaaaca gtgccgcaca aacgtaccta acatttatgc 1419781 aatcggtgat atcatcgaag gaccgccgct tgctcataaa gcatcttacg aaggtaaaat 1419841 cgctgcagaa gctatcgctg gagagcctgc agaaatcgat taccttggta ttcctgcggt 1419901 tgttttctct gagcctgaac ttgcatcagt tggttacact gaagcacagg cgaaagaaga 1419961 aggtcttgac attgttgctg ctaaattccc atttgcagca aacggccgcg cgctttctct 1420021 taacgaaaca gacggcttca tgaagctgat cactcgtaaa gaggacggtc ttgtgatcgg 1420081 tgcgcaaatc gccggagcaa gtgcttctga tatgatttct gaattaagct tagcgattga 1420141 aggcggcatg actgctgaag atatcgcaat gacaattcac gctcacccaa cattgggcga 1420201 aatcacaatg gaagctgctg aagtggcaat cggaagtccg attcacatcg taaaataatt 1420261 ttcatatcaa aaacagcccc gctttgagcg agggctgttt ttttattttg acagcacatg 1420321 ctgtaatggt ttaatgatgt cttctttctt tttcacacat ccctcgattt tcaccacgac 1420381 atggcgctga tcaacaacca taagggtagg gacagtttca atctcatctt cccagccttc 1420441 ttttttatca tagaccttca ttttatctat ttgctcggga taatcttttt ctaaatcaag 1420501 cagtgcatcg taataaggcg cttcctggtc tatttggttc tcatcagaaa aaaacaggat 1420561 ttgtgtatga tgaatgttgt caatccggct ttttttcatc ggattgatgg tggaaagcgt 1420621 acagcccgat aaagcaaata ctattatcag catggggaat accgcgcgat atcgcatcta 1420681 tcttctcctc tgtataaaca gtagttaact agctttagtt tatcacgaga gacggcttaa 1420741 tctgcttctt gttacctaat tgttatataa ttgaaaccgt ttttaaagtg agattacata 1420801 ttatatcaat cgtttaaaat agcaacctgg ggtatattga attttttgct gcattcttgg 1420861 atgaaagttc aagaaaacgt gcaattacat tatgtgctgt ggcatatata tcgagtaaag 1420921 cttctgtatg aagaagatat tgtatgatgg aaaatggaaa aacaaggtga atatgatgat 1420981 atgaaataaa atgtgttata cagtttgttg ttgacatttt aaatgtgaca tattaatata 1421041 ataacaacaa aagaaattaa gcgttttcaa atttcaaaga aatggggaat aagagatggg 1421101 tacgattgtt tgccaagatt gcaacgaagc cattcattac tttgaagatg agaaagtgac 1421161 aacattatat ggaacttgct gcggacaatg tcaatgtcct gttgatgaag agtaaaaaaa 1421221 agcatgcggc ttaaagccgc atgcttttta ttttttattg aattgctttt tgttctttga 1421281 tgacccggat catatgtaaa gtcgagtcct caggtccttg aacagggagg cctgcgtcaa 1421341 ggtttttaaa aatgtagctg atgttttctt ctgtaataat ttctcctggg atgaagattg 1421401 gaataccagg cggatatacc atgacaaatt cagcaataat ccgtccggat gcttctttta 1421461 atgggatgac ttccgtattt gcatagaaag catcacgcgg agtcattgcc aataaaggta 1421521 tttctggaag cagaacctca gtttgctgat gtgttacatc ttgttctgac atttgctgtg 1421581 cgatctcagt taaagcctct acaagccggt ctgcatcatt ttggctgtca ccaggagtga 1421641 aaatacacaa aatattgtac agatcagaaa gctccacctc aatattaaag gattcacgaa 1421701 gccatttttc cacgtcatgt cctgtcaggc caagactttt cacagagata atcaattttg 1421761 tcggatcata gctgtaagct gctttcgacc caagaatctc agaaccgaca caataaatgc 1421821 cttcaatctg attgaggcga tctctcgtct gattggcaag cttgagtgtt tcctcagcaa 1421881 gctggcggcc ttctgttgca aggcgttttc tggcaacatc caaagaagcg agaagcaagt 1421941 aagaagttga cgtagttgtc agcatgctca ggatggattg cactctgtct ttagatacaa 1422001 ggccttctct catgtttaaa atagagcttt gtgtcagtga tccgcccagc ttgtgtacac 1422061 ttgtcgctgc tatgtccgct cctgcctgca tagccgatag cggcaattcg tcgtgaaaat 1422121 gaatgtgaac gccgtgtgct tcatccacaa gcactggcac atcaaacgaa tgagcgagtt 1422181 ctacgatgct ttttaagtcg gctgcaacac cgaaatatgt cgggttgatg acgagaagcc 1422241 cttttgcatc cggatgctcg gtaagcgccc gtttagcaga ttcaagtgta attccgtggg 1422301 agatgcccaa ttcattgtca atttcaggat gaataaaaat tggaaccgct ccggaaaata 1422361 caatagctgt cataattgat ttatgaacat ttcttggaat aataatttta tcaccaggtc 1422421 cgcaaacagc cattaccatt gtcataatgg cgccgcttgt tccttgaaca gaaaaaaatg 1422481 tatgatccgc tccaaatgct tcagcagcca gatcttgtgc ttgtttaata atgccttttg 1422541 gcgcgtgcag atcgtctaat ggttcaatat taatcaaatc tatgcttaac gcgttttcac 1422601 cgataaattg tctgaattct gggtccattc ctgccccttt tttatggccg ggaatgtgga 1422661 attgaacagg ctgtctgctt gcatgctttt tcagtcctgt gtataagggt gtttcatgtt 1422721 gcgacaattg ttttcccacc tttgtaatca tacctatgca taatagtgtg tattaaaatc 1422781 agtttctcaa ccgtttttta gacgtaaaac aaatgaatta tattatgaac ttgaaagaat 1422841 gtaaagaaca atttatgatc aaatgaagat gctttctctt aagggaagta aatctacaag 1422901 gagtgaagaa aatggagtat caatatccga tgaatgaaga ttggacaacc gaagaagcag 1422961 tggatgtgat tgcatttttc cagcaggttg agcttgcata tgaaaaaggg gcggatcgtg 1423021 aagaactgct taaagcttac cgccgtttca aggaaattgt accggggaag gccgaagaaa 1423081 aaaagctatg cggcgagttt gaggaacaaa gtacatattc tccttatcgc acggtcaaac 1423141 aggcgagaga atctgatcac gcgaagatta agatgtaaga aaaagagccg ggggatatcc 1423201 cggctctttt ttatgcttgt gttacttttt gggtgagacg gtacagaaaa gcaagctgtt 1423261 taaaggcatc gtcgatacgc tgaaggaatt cctggttatt catattcagc acttcttctt 1423321 tttggagctg gatgccgcat aacagctcgg ctttctttac agtctgcaaa cgctcaaaca 1423381 gtgtcttcag ctgttccttg tccatttcag actgtttatg tactcccggt tttgtgtgat 1423441 ctgcagacca aacgaagctg tcagggatat ttttcgtaat ggtttcttgg ttcacttcaa 1423501 gcaatttgcc gtattcttct ttgatagggg attcataaat aatcgcgaac catacaaaga 1423561 cgtggctttc ccataaacca atttggaaat gcggcagttt tttatagcct cttttgctgt 1423621 ttgcgaacgc cacccagctg tcagccgggg gattgacgga tcttcttgcg tgctttgcca 1423681 catgcggaaa catttcatct ccggttaaag ctgataaagt tggggcaaaa tgttcgccta 1423741 gagctgtaag cttcggacgg accgtctctt ttaatacttc catgcgcgcg tctaagcctt 1423801 ctattgtaaa tgtgttaaag tcttcttcag tgaaacgcat ttgtgtcatg attttcctcc 1423861 ttcatgctaa gtatacatat tttatcacag ttcatacgag cttcaaaaag attgagcgcg 1423921 tttgaagtaa ggagaaatgt ggtaataaac gagtaggtaa acacacaatt ttcagaatca 1423981 tgttgcgcgt aaatagaaca atcatacgat ataagaagta atcattgttg aatggcaaaa 1424041 tgggatgctt ttttacaaac aaatgatctc tggaaggggc gaaagacaat gaggcaagtt 1424101 gtaaaagagg gatttaagga agagaaaaac aatcgtgttg ctgtctggag actagaggtt 1424161 gattatgaat tggcaaccct atatgaagca atgcagaaag aaaatgaaga gcagattgaa 1424221 caaagcaaaa acaaacttga gcgacttaga aaagaatgga ttcgtcttaa cgggtaaaaa 1424281 agcgatagtg aaaacgaacc gcatgaatgg ttcgttttta cgtgagaagg gatatttttc 1424341 attttccttg ctttttcatt gccgttatca gtatcctata aaataaaagg tctacataga 1424401 agagaggtac gaacgaatga caaattggac ggaaatcgat gagattgcaa agaaatggat 1424461 aagagaagca ggcgcgagaa ttacacaatc catgcatgaa agcctgacaa ttgaaacgaa 1424521 atcaaatccg aatgatttag tcaccaatat tgacaaagaa accgaaaagt ttttcattga 1424581 tcgaattcaa gaaacatttc cgggacatcg gatactcggt gaagaggggc aaggagacaa 1424641 aatccactca cttgagggag tcgtatggat tattgatccg attgatggga cgatgaattt 1424701 tgtgcaccag caaagaaatt ttgcgatttc cattgggatt tttgaaaacg gtgaaggtaa 1424761 aatcggttta atttatgatg tggtgcacga tgagttgtat cacgcattta gcggcagagg 1424821 agcttatatg aatgaaacga agctggctcc attaaaagaa accgtcattg aagaagcgat 1424881 tcttgccatt aatgcaacat gggtaacgga aaacagaaga attgatcaaa gtgtgttagc 1424941 gccacttgtg aaaagagtca gaggcacacg ctcctacggt tctgccgctt tagagctggc 1425001 aaatgtcgcg gcaggaagaa tagatgctta catcacgatg cggcttgcgc catgggacta 1425061 cgcagccggc tgtgtgctgt taaatgaagt aggaggcacc tatacgacca ttgaaggaga 1425121 gccgtttacc tttttagaaa accacagtgt gctagccgga aacccatcta tacataaaac 1425181 gatatttgaa gagtatcttc atgctcggaa gtaggccatt tgagcaggat gatctcagct 1425241 tgttagaaaa gctcgcggag gctcatcctg tatggaaaga ggaggagttt ggagataaag 1425301 atgcagaaga ctatatcatt tcctactcca tgtacaacgg ttcatggctt gtatgggaaa 1425361 aagacggtat gcctgttgcc gtcagctacc atctcgagtg gtctccttca aacggtaagc 1425421 cgtggctcgg aacggtcctg attgacccgg ctgaagaaaa aaagggacat gcgaagatga 1425481 tcattgaaca gatcagcaaa ttgcttagag cgaaacataa agcgatgttt gcgggagttc 1425541 ccattgagcg cagggaatgg atactgtttt taagccaatg cggctttgaa cagctgaaaa 1425601 cggaaaaaga tgagaaaggc aaatcattta tgatcttggt gaagccttta gcagaagctg 1425661 ccgtatgata atggcagctt atttgctgca tgcgggttca ataaaaagcc tctcaaacat 1425721 tgagaggctt ctgatgattt gaaaattatt tttttaccgc atgaatataa tgaatcgttt 1425781 caaacgctga caaattgtct tttcgattac taaagaaaag gtcattgatg tcgtctggtg 1425841 atagatgttc atagatcagt aaaccagatg actctaacag atgttcaatc tcttgataag 1425901 tgaaacatga tttcatcggt tccccgcttg cggcagccat cttcaccata tgttcaactc 1425961 gattcgacgt cccttttgct gtaaaaagtg tttcgtccgc ataatcaaaa acaatagagc 1426021 ttccaggcgg gacatgagaa aataaattgc tgatcaagct tgcattttct tcccgtgtta 1426081 cataataaga cactccgaga aggctgaaga atgtttttgt gtttttaaat ccttcatcta 1426141 agagaggatc atacgaaaac gttttggtga aatccatagg aacaaaatga agatgacccg 1426201 gaattgtcag atttgcatcc ttcagcttat tttttttcaa ttgctgtgtg gccggatgat 1426261 caacctcgaa aacctgtaag ctgttttcta attctggatg ccgaaagcag aaagtatcca 1426321 gtcccgctcc aagaatgaca tactgttttg cccccaggat taattcgttg tgcaagactt 1426381 tttcacaata agaagcacgt gctaggggcg ttggagacag ctggatttgt gcaacccatt 1426441 ttaatatttt ttcaggatca ttttgaagac gttcggcgat ctctttgttg aaaaacgata 1426501 tttcttgaat catattttta ctgatgtcga taaactcttt ttcgttaatg agatcttttg 1426561 cgataaaatc atcaaaaata agaggtgtgt catatcggct gtgatatgca cgggcaaaag 1426621 ctgaaattag agacgttaag ctggactcat ttttcctcat gaaatgatcc tccacaaaaa 1426681 ataagattcc cctggccagg agaatcttat tatacataca aatatattaa tagtaaattt 1426741 tagcataaat aaattttttt gtcaatgttt ttgctcttaa ctggacgcgc gatccttcac 1426801 atagccacgt gacctgtagc agaattcgtc tatcaattat gtggactgaa tcattagctt 1426861 ttataaaatg cgcacttgcg gctgcatccc tctttatgca aatcaggagc ggttttctgt 1426921 ctcatggcag catcttttcg tcgtttcagc tgagagagaa atcaagatat gtaacaataa 1426981 aagcctgagg gatctcaggc ttttcctaat attacaatcc aacagcattc caggctgctt 1427041 caactttagc ggcatcagtt gagccgtaga ggtcacgggc agactgaatg agagctgcct 1427101 tggcatcttt gaacgtggaa gaaggcgtga ggtacgttgt taacgcacgg taatagattt 1427161 gctgtgattt agatacacca agttttgtga tggtgttgta agcggctttg tttggaattc 1427221 cgctgtttgt gtgtacaccg ccataatcgc cttcatctgt gtttggaagg tttcggtaat 1427281 tggcgtaatt gtcaggctgg ttgtattttg tagggttgga caggctgcga agagcaggct 1427341 ggctgaccgt aatgtcttca ccgatgtccc agtcttctgt atcgttaaaa tacccgaata 1427401 cgtcagagaa agactcgttt aatgcacctg gctgattttc ataaatcaag ttggctgttt 1427461 cttgggtgac gccatgtgtc atttcatgcg ctgtcacatc taatgagccg gaaagcggag 1427521 agaagaatga accgtcgcca tcaccgtaaa tcatctggtc tcctgtccat gcagcgttat 1427581 tgtattgagt gccgtagtga acggaagaaa cgattttact gcctttgtta tcatagctgt 1427641 ttcgtttaaa gtttgaataa aaataatcgt acactttacc gaggttatag tgtgcgtcaa 1427701 cggctgcccg ctgtgatgaa gatgtaaatg ttttcgttgt gcttgagaca agcgtgcccg 1427761 gaaggcggct ttgtctgttt tgcaaatcat atgtgatgat ttgggtgcct gttggttttg 1427821 aaagatctct tagaacatat tttccgcctt cataagagat gttcaaagga acagttgcgc 1427881 cctttagcgt tgttccgctt ccagtggcgg cggcatgttc tactttattt tgctgtttta 1427941 aaatgctgcc tgtttcggcg tcaactaaga cttcccagtt tgcaggttca ggctcgacat 1428001 agcgaatcgt cacgtcgtaa gcaagacgat agctgccgtc ttttgtttct atcgctttta 1428061 attcggcttt attgctgttt ttggccgctc cgttagaaac agcgtctggt gatttgccga 1428121 tagctttgaa agcgagtgcc agcgcttttt cagaagagac tttttggctg ttatctgttt 1428181 ttgcagcaga ttgattgtgt aattcaccat tgaccgcata gacattatcg gatttatcga 1428241 cgtgaacgat cacttgcgaa tctttaattg gcactccgtt aacgacaggc gcatatcgaa 1428301 agtgcttgta tccaagggca tcagtcgtgc tttcaacaag cttcagcctt ttggaagggt 1428361 cacctttaaa aatgttgctg ttctttttca aaaactgctt gacagccttg tcatttggtg 1428421 cagagagttc tgattgcgca atcgcgtttt tggagaggaa atttgtttga ttctctttaa 1428481 gctgatgacc ttcagcagcc tgaacacctg gcaggctgat tgataaactc ataaacgaag 1428541 cagcgacagc aacagacaat ttcttaccta aacccacaat aaatccccct ttttgaaaat 1428601 actgaaaact ttatattgtt atattaaact agcattctgg aatactcaac aaaaactaac 1428661 ataactagac aaaattgata gtattgtcct gtgtttgttt ttgttgaata atatcaagat 1428721 gagtcaagtg tcatgtggtg gttcattcaa gagttatgtt ttttacatat caaggggaag 1428781 atgagatatt tttgtttcat cttgaaactt tttgaaaagt ccgctgtcta accgaatgag 1428841 gccttaataa gaagtaaagg attgttgttc gtgttggagt tattcagtca ttatgtattg 1428901 catttcgaac gttattttat attaagcaga caaagcaccc tgctgattca atggtcaatt 1428961 gttgttctgg cgggcttata tcttttggtg catcatccca aaataaaccg gcagcgcaca 1429021 atgttcttgg cgggtgttat attgcggatt gtgctgctgg cgggagtgtc tgttgaactt 1429081 attcaccagg tgcaatcaac aaacttcacc agcgcttact taagagagga cggaaaagaa 1429141 ctgctgccgc tgctgcattt tttgttatac ggatatgtgc tgctgacggc ttttcactat 1429201 atgctgatgc cgcgtgatca tggcggaaag ggtaagtttt atacgttcga ccttgctgtt 1429261 gtcagtttgc cgatcgtaca aatgattttt agtttctttt cgtattggaa ggaatacccg 1429321 gatgggatgg agccgattgc attcgtgttt ctgtttttca tcatcactct tcccattgcg 1429381 ttgaatgtag tgtttttcaa gctgtattgg agaacggata agatcttact aggcttattt 1429441 tatacgctga ttatcggact gcttgtcttg ctgcttgcgc catatcccaa tcaaatctca 1429501 aaagattatg gtgcagtaat gccatatacg atttatttgg caatggcggg atttttgatg 1429561 agctatcatc tgttccaaaa gtcaggaaag gtttatgtgc gtgtgaataa gtgggtgacg 1429621 atggctgtca tggtgttttt tgtcctgctg ttaaatccga tatataacat aggaacggct 1429681 gctttcgctg tatcaaagcc agcaaatgtc catgattcat tcaattttgt cggggagcac 1429741 atttcatcag aaaaagcgga acagatacta aagtcatttt ttcctacgga tgaaacactt 1429801 tatttgcacg atacaaacat ggatgtgcat tatttctact catttgaaag caaaggttac 1429861 aaagctgagg tagatgaagt atcgcagcta attcgtaatt atgaatactt acaaaaagca 1429921 catgggaaaa agctaacgaa tcaggagtac aagcgaaagt ccatcgcttt ccttgagcga 1429981 cacggacgtg tgttacataa ggatcatatc gaaacaaagg tatctcaaga agacggccag 1430041 acagtcgtac gtatttacct gaaaaatcaa cttcataaaa aagatcatgc tgatgatggc 1430101 gcggtatttt attgggaaaa ggaaacctta atggggttta gtgaagatcc ttcgatttat 1430161 cagcttgact ctcttctgca tgttcatata acggaacaag acattcacga caaagtggaa 1430221 caaatgttta cagcgctgaa catatcaaaa cagccttatc agatcactga tattgaaagc 1430281 gacagcctgc ttggaagcat ggtgagagtt gaaacaaaag ttggaattgt tttggaattt 1430341 gagggcgaat caggttgttt acatagtctt tcgcttccga tgaaaaagaa tatctcaatg 1430401 gctaacagcc ggctgcagca tcagatatta tcgatcttcg atgctcgtgg atcagaaaag 1430461 aagaaaaaaa gcagtcaggg tgacatggtg atgtatactg attcttctaa aacatatgag 1430521 tttgttgaag ctcaaggtca gctaaacgtt tatgtataca gcgatacacc tgatcagtca 1430581 ttcccctata cgtatcgtaa tggaacattg gcttacgaaa aagtagcttc tctatatcag 1430641 gatgtcattt acaaaaagcg tatgcgtccg attatcgttc aaagagggga tgaacggcat 1430701 tatgcatggc tgatcattat tcagccgttt ggttcaaatc gccatgatgc ctatgtagtg 1430761 gatggagaaa cacaagaggt gaaaagtctt tatgaatcat aaagaaaaag agtctgtttt 1430821 tgtagactta tacgacctgt ataaagaagg agagctagag gatgaatcaa tggaatggat 1430881 gaaacagcat gaatccctat ttcaaaagaa tgcggaagac ttaaagagta aaacttgttt 1430941 aaagagaagt cccggtgctg aagaagaaag ccaaatcaga tatatgaaag tatacctgtc 1431001 ttccatgtat atctgtttca ttttattggc catttggatg acggtgtggt tttattttta 1431061 atgaagcata gggattccat tgaggacttg tatcggcagt attatcaaga aattttaaat 1431121 tatttattca gaaggactca tcatcttgaa acagccaagg acttagcgca ggacacgttt 1431181 gtaaaagctc ttaacggtct ggcttcgttt agggggcatt cttccatcag aacatggctc 1431241 tacaccattg cgcatcatac ctttatcaat tggtaccgaa gggatgtcaa ataccaattt 1431301 actgaaatca gcaaaaatga agggttaacg caaacaactt atgaccagcc tgaacagtat 1431361 ctgtcacgga cggtgaaaag cgaaacactg cggcaggagc tcctgaagtt aaaagatcag 1431421 catcaatccg ttttgatttt aagagaattc caagagcttt cttatgaaga aatcgctgag 1431481 atattaggat ggagtctttc taaggtgaat accacattgc accgggctag attagagcta 1431541 aagaaaaaca tgacgaaaag tagagaggag gagcggatat gacctgcttt ctagtaagag 1431601 acctgcttcc tctgtatctt gaaggtgatt gtaaaagaga aacggaacac gttatagaag 1431661 agcatttaaa aatgtgcagc agctgcagag acatgtatga cacgatggct gagccatttg 1431721 aattggaaag cgaacaggcc gttgaggagg cttatctgcc ggaagaagaa ctgcgtttta 1431781 aacagaggta ctatggatta ctgatcatga aagctgcctg ctggtttgga gcggcggttg 1431841 ccatgatgct gatcatcaaa ctgctgatat aaaaaaagcg cttgtccgat tccggcaagc 1431901 gcttttttac attaagcctg gggatgaatc atatcgtaaa tagcggcaag ctgttcttgt 1431961 gacagggcac tgaagagttt ttcataaacg tcagcttgca gtggcgttgc acctgcttgt 1432021 agcgctgcgt ctttatcata gctgtacaca tcatcttgta gcacaatggc tgcttgaaga 1432081 atgtgaatct tgagagaaac agcggagaaa aattgttcaa gtgcaagtgc ttctttttct 1432141 gtgaagccaa gttcaactgc tttttctgta tcaaatttgt aatttccatc ctcgagatac 1432201 acacattgtg aaacaatgct gaaaaattct gatgtcgatt cccagagtgt agcaattacc 1432261 tgagcctctt cttttgtcat tcctaactcg acagcttttt cgctgtcaaa ataatataca 1432321 ccgtcttgtt cgtatataca ttgatttaat atatcaatga atgtattgag atcttcgtta 1432381 gtgctcgcct gatgctggag ttgaacagca gtgttatcaa ccggtgtttt tgcgctggct 1432441 gcatcaggac cgaacgttaa tagagcagct gaggtcattg cggcagtcgt taacatagct 1432501 ttttttacaa atgttttctt catgtttctt ctctcccttt tatgaattgt gctacaaatt 1432561 ccattatagg gagtagtttc cggtggagga ataggcgcta tggtatttta tgtgtatcgt 1432621 tgccgaacta ctttttgaag gctgcacgtg tgatcgttag aacgattgtc tatgtatgaa 1432681 ggctgttttg catcttcctg actaagaaac aggggagata aggcttaaag aaatgaaaaa 1432741 caccgctttc tttgcggtgt tttttgatta caatgtcgcc ggcggggcaa tgcttttaat 1432801 caagcaagcc ttgttcgcgc attttctttt ttaatgtaaa tccgccgccc atgacagcgc 1432861 aaacaagtac aatgctggcg ataatgcctg cagggctttt ttcagcgata aagacgccga 1432921 tcagcataat gctgaaaacc gctgcaaatg caaataatag taaaagccaa ttcatttttt 1432981 tcataaattc catccccttt tacgtcttat attaagttta cagaaaaacg tgacgctttt 1433041 aaagaggatg tgtgatataa tatgaaagtt atctaatttt tttaggagat gaaaaagtga 1433101 aacttcgaaa tgatcttcgc aacatcgcga ttattgccca cgttgaccat gggaaaacga 1433161 ctctagtcga tcagctttta catcaggctg gtacgttccg tgccaacgaa caggttgctg 1433221 aacgcgcaat ggactctaat gatcttgaac gcgaacgcgg cattacaata ttggcgaaaa 1433281 atactgcgat taactataaa gatacacgta tcaatatttt ggacacccct ggacatgcag 1433341 actttggggg agaagtagaa cggattatga aaatggttga cggcgtagtg cttgtcgttg 1433401 acgcatatga aggctgtatg cctcaaactc gttttgttct gaaaaaagct cttgagcaaa 1433461 acctgaaccc tgttgttgtt gtaaacaaaa ttgaccgtga ctttgctcgt ccagaggaag 1433521 ttatcgatga agttctggat ctgttcattg agcttgatgc caatgaagag cagctcgagt 1433581 tcccagtggt atatgcttcc gcgattaatg gaacagcgag tcttgatccg aaacaacagg 1433641 atgaaaacat ggaagcttta tatgaaacca ttattaagca tgttccggca cctgttgata 1433701 atgcagagga gccgcttcaa ttccaagttg cccttcttga ctacaacgac tatgtaggcc 1433761 gtatcggaat cggacgcgta ttccgcggca caatgaaagt cggacagcag gtttctctta 1433821 tgaagcttga cggaacggca aagtcattcc gtgttacaaa gatttttggt ttccaaggct 1433881 taaagcgtgt ggaaattgaa gaagcaaaag cgggagacct cgttgcggtt tccgggatgg 1433941 aagatatcaa cgttggtgaa acggtatgtc ctgtagacca tcaagatccg cttccggtcc 1434001 ttcgcattga tgagccgaca cttcaaatga catttgtcgt gaataacagt ccgtttgcag 1434061 gccgtgaagg caaatatgta acggcccgca aaatcgaaga gcgtcttcaa tcacagcttc 1434121 agacggatgt gagcttgcgt gttgagccaa cagcttctcc tgatgcttgg gttgtttcag 1434181 gacgcggtga gctgcacttg tcaattttaa ttgaaaatat gcgtcgtgag ggctatgagc 1434241 ttcaagtgtc aaaacctgaa gttattatca aagaaatcga cggcgtacgc tgtgagcctg 1434301 ttgaacgtgt gcaaattgat gttcctgaag agcatactgg ctctgtaatg gaatcaatgg 1434361 gtgcccgcaa aggcgaaatg gttgatatga tcaacaacgg aaacggccaa gtccgtctca 1434421 tctttacagt tccttcccgc ggattgatcg gttactctac agaattccta tcattaacac 1434481 gcggattcgg tattttgaac catacgtttg acagctacca gccgatgcag gcaggccaag 1434541 tcggcggacg ccgtcaaggt gtacttgtgt caatggaaaa cggaaaagca acatcatacg 1434601 gtattcaagg aattgaagac cgcggtgtca tcttcgttga gccgggtact gaagtatacg 1434661 aaggaatgat cgttggagag cataaccgtg acaacgacct tgttgttaac gtcagcaaaa 1434721 tgaaacagca aacaaacgtc cgttctgcga caaaggatca gacaactaca attaaaaaag 1434781 cgcgcatcat gtctcttgag gagtctctag agtacttaaa cgaagatgaa tattgtgaag 1434841 taacacctga atccatccgt ttaagaaaga agatcctcaa taagaacgaa cgtgaaaaag 1434901 cagctaaaaa gaaaaaaaca gcaggattgt cttaatctcg tgcagaattt gaaaagatag 1434961 aacccgtacg tttacagggg agggaatctt tttgaatgac gtaagcgaac gcctgtcgtt 1435021 cttcgccgct ctatatcaag tagaccggca gcctgcggca ggcatgtggc tgctgtacgg 1435081 cacgattttt gtgttggccg ttattgtatt taagcttgga tttgctaaac ggcttcctgt 1435141 attaaaatct gcagtggtgt atgtattttt ggctttgggc tgcactgttt tgactttttt 1435201 aggggtgttt ttgcccgtgg cagaaggatt ggtcgtcgct gcgctgattt taatcattta 1435261 caaaatccgg ctgtatcagt cgaaaaaagg acagtctgca aaatcataaa agactcagct 1435321 gaaagctgag tcttttttgt gttctgtatg gttaagcggc cgctttattt tttgactttt 1435381 tcttttttct gctgtcccgg gtgaaaagta aattttcccg ttttcagccg ttcctctgtt 1435441 tttttggcaa tccgatcgtg gcattcctgg cacatatatg tatggatcgg gcggtttcga 1435501 agccgtttcg cgatcagggt atcatcatca attgtttcaa ttttatcgca aatagaacat 1435561 ttgaccctca tcatatcacc tctttcacta acatgtatta taccacggat cagaagctgt 1435621 ccaaaataag aaaaagctaa agcgcaaggc tatagcttag tcattgttgt tctttttcat 1435681 atgatgatca gattgatcgt tttgttcctt ctccatttcc tgttgctgtt ttctatttaa 1435741 ttggtcattt tgctgctttg tttgcggttc atcttcattg tcaatcacat cgttaggcac 1435801 ttcgggaagc actcggccga caattgcagc taattcatcc agtatacctg ttaccggatg 1435861 gccctcgctg atttctctgc tcatttcgcg aaggcggctg accgtatcgg gatcagcaat 1435921 gactactgcg ttggcgccat atcgatcatt ctttagcgcc tgagctacag aatatttaat 1435981 ggtttccact ttgcttctgt ccaaagtatc atcgacatca atcccaacaa cagcatagcc 1436041 tcccagcaca acggctgttg catccttgac gtcggggttt ttttcagcaa cgctgacaag 1436101 atgcttggca atatccgttc ttgttccatt gtcttttgtt tcttgagttg tgtcctttac 1436161 gtgaatcggt ttagtctcct gctgtcttgt tgattctttt tcaacattct ggccctgttt 1436221 tccttgttga taggcacaag cggacaggat aagtgtcagc tgtatgataa tgaaaagaat 1436281 tcgcacttgc gggttccctc cttaaaatgc tttcattaat tttattgttg aattaacctt 1436341 ctatctttat gcacaaaaac atatatttta gcaggcattc acctttttca tcaaaagaga 1436401 agcaggaaga actttgaccc ttatatcagg aggctgagac ttgagtaaaa tttatgtgtt 1436461 agatacgaat gtgttattac aggatcctaa cgcgatattt tcttttgaag aaaatgaggt 1436521 tgtcatccct gctgtcgttt tagaagaggt tgattcaaaa aaacggtata tggacgaagt 1436581 tgggaggaat gcaaggcacg tatctaagct aatcgatgcg ctaagacaaa agggcaggct 1436641 gcatgagcat gtaccgcttg acaccggcgg cacactgaga attgaactga atcatcgttc 1436701 gtttcaccag ctgcaagaga tctttattga aaagacgaac gataatcgca tattagccgt 1436761 tgcgaaaaac ttaagcctcg aggaagaaac caaggaaaat ggcaggccgg ttatccttgt 1436821 cagtaaggat gtactggtca gggttaaagc cgacgcaatc ggactgcttg ctgaagattt 1436881 cttgaatgac cgggttgtgg acaatgatga aatgtacagc ggctataaag atttatatat 1436941 cagccagcag ctgttcagct ctttttacgg gaaaaatcaa atttcagtaa acgatgtgaa 1437001 acagcatgcg ttttatccga atcagtttgc tttaatgaag gatgagctag gagggtcctc 1437061 ctcggcagtc ggaattgcag acaaaaccgg aacggtatta aaaagactcg tatttgatga 1437121 tgaacatata tggggaatca ggccgaaaaa tgtacagcag acaatggcat tagagctttt 1437181 gctgcgggaa gatattccgc ttgtcaccct gatcggcaaa gcgggaaccg gcaaaacgct 1437241 cttagctttg gcggcagggc tattacagac agaagacttg ggaatatata aaaagctggt 1437301 cgtcgcaagg ccgattgttc ctgttggcaa ggacatcggg tatttgccag gcgaaaaaga 1437361 ggaaaagcta aagccttgga tgcagccgat ttttgacaac ttagagtttc tgtttaatgc 1437421 gaaaaaacca ggggagcttg atgctatttt ggcgggaatt ggctcaattc aggtagaggc 1437481 gctgacttat atcagaggga gaagcattcc agatcaattt attatcattg atgaagcgca 1437541 aaatttgacc aggcatgagg tgaaaacgtt gctgacgaga gtcggtgagg gcagtaaaat 1437601 tgtcttaatg ggcgaccctg aacaaattga tcacccatat ttagacagtc tgaacaatgg 1437661 tttggcctat gtggttgagc ggtttaaagg acaacccatc tcaggcagcg tgaagctgtt 1437721 aaaaggtgag agatcaggtc tcgcccagct tgcagctgat ttgctgtaac acttaaatga 1437781 tttcgatctc ttttacatcg gtaatcggct gtttgtgatg aaccgggtct tcaaagtaaa 1437841 tatgcacggg gccgccttct tgaatcggct tgcctgcctc actgaaatgg acaatactgt 1437901 tcagagcggt ttccagagaa acggcggcct ttcccgaact tgtgacaaat acacattgtg 1437961 tcgcagagct gttcggctca gcatttttca ggacagtccc aagtctcatt gcgaaactgc 1438021 cgttcatcag tttttgcttc tcatattgct tttccgtctt taatgtaggc ggcgcgattc 1438081 gcccctctct gatgacgcgt tccggatcaa ggtcggattc atccccggct gattgtaaat 1438141 atgtgtcttg actgtcccct ttgcggtcaa acgaaaattt gcgatcatca aaaatccata 1438201 cgcttggatc aatggtaatt ggatatgtaa cattgccttt tacttggata acgctcatga 1438261 tatgaccccc ttctctcaaa attataaaag ttttcgcatg aattgtcact ttgtgtacaa 1438321 attatgtgta ttgaaatgct gagggaacga gggtgtttgc atggtatgcc agcataatga 1438381 tgagcttgaa gccttagtga aaaaggcgaa aaaagtaacg gacaaggggg aggtagccag 1438441 ctatattccc gccttggcaa aagctgataa acacgacctg tcagtggcga tttattattc 1438501 caataatgtt tgtctgtcag caggtgacgt agaaaaaaca tttacgcttc aaagtatatc 1438561 gaaagtcctt tcccttgctt tggtgttaat ggaatacggc aaagataagg tcttcagtta 1438621 tgttggacag gagccgaccg gtgatccgtt taattcaatt atcaagctcg aaacagtgaa 1438681 tccgagcaag ccgttaaacc ctatgattaa tgccggggca ttggtagtga caagtctgat 1438741 aaggggaaga acggtaaaag agagacttga ttatttgctt tcttttatca gaaggctgac 1438801 aaacaaccaa gagattacat actgccggga agtggctgaa tctgaataca gcacttcaat 1438861 gattaatcgg gcgatgtgtt attatatgaa gcagtacggc atttttgaag atgatgtaga 1438921 ggcagtaatg gatttatata cgaagcaatg cgcgattgag atgaacagct tggatttagc 1438981 gaaaatcgga tctgtattcg cattgaacgg cagacatcca gagactgggg agcaggtcat 1439041 ctcaaaagat gtcgctagaa tttgcaaaac gtttatggtg acgtgcggaa tgtacaatgc 1439101 aagcggggaa ttcgcaatta aggtcggaat tcctgcgaaa agcggcgtat ccggcgggat 1439161 aatgggcatt tcgccttacg atttcgggat cggcatattc ggccccgcat tagacgaaaa 1439221 agggaacagc attgcaggtg taaagctttt ggaaataatg tctgagatgt acaggctgag 1439281 tattttttaa tttatgtcat atgcttaaat cctcttgcat tttctgttga taccctttat 1439341 gataaataga agaattaggt actcgcctgg ggaacggagg gatacttttg gcttcagaga 1439401 tgatagttga ccatcggcaa aaagcttttg aactcttaaa agtggacgct gagaagattt 1439461 tgaagctgat ccgagtacaa atggataact taacgatgcc tcaatgtcct ctatatgaag 1439521 aggttttaga tactcaaatg ttcgggcttt cgagggaaat cgattttgct gtccgcctgg 1439581 gattggttga tgaaaaagac ggtaaagacc ttttatacac attggagcgc gaattgtctg 1439641 ctttgcatga cgcgtttaca gctaaataaa tgataaaact caaacttatt aacagtttgg 1439701 gtttttttat aaccgctatt tttctctcat ctcataaaag acggtctttt tttacacatt 1439761 ccttccgaat cgtatagaga ttcttcgtct cgtttgataa attgtagtaa aataaaaaag 1439821 ataaatacat aaaaaccata gataatggaa gttagaagca gggaagagga tgttatgtta 1439881 aaaaaaatgc taaaatctta tgattactca ctgatattcg caatcgtttt attatgcgga 1439941 ttcggtttag tgatggtata cagctcaagc atgattacgg ctgtctcccg gtatggagta 1440001 agcagtaatt ttttcttcat gcggcagctg tttgctttaa ttgcgggtgg cgctctattt 1440061 attctcatgg cgttgtttcc ttataaagca ctggcccatc aaaagtttca gaaggggata 1440121 ctgcttgtat ctgttcttgc gcttatctca ctgtttgttt tcgggcatgt tgccggaaac 1440181 gcgcagagct ggtttaaaat cggcggaatg agtattcagc cgggggagtt tgtgaaactg 1440241 gtcgtgattt tataccttgc agccgtatat gcaaaaaaac aaagttatat cgaccatctg 1440301 ttaacgggag tagcccctcc ggtagtcatg acgcttataa tttgtgggtt aattgccatg 1440361 cagccagatt tcggtacagc catgattata gggttaattg cgacgtgcat gatcttgtgc 1440421 tccggcttca gcggaaagac gctggtgagg cttgtgatac tgggcggaat tgttttcatt 1440481 ttagtcagcc ctattatcta tttgaatcag gacaaaattt taactgaagg ccgtttagcg 1440541 cgttttgaga gtcttgaaga cccatttaag tatgcaaatt catcaggttt gcaagtgatc 1440601 aattcttatt atgcgatcag ctcaggcggc attttcggcc tggggctcgg tgaaagtatc 1440661 caaaaatacg gatatctgcc tgaatcacac actgacttta ttatggctgt cattgctgaa 1440721 gagctcggca tttttggggt attgtttgtg attttcttat tgggttttgt cgtcataaaa 1440781 ggtttttata ttgccagaaa atgcgaggac ccgtttggaa gtcttctggc gatcggcatt 1440841 tcaagcatga ttgccatcca gtcgtttatt aaccttggcg gtgtcagcgg attaattccg 1440901 attacagggg ttacgctgcc atttatcagt tacgggggct cttctttggt gctgctgctg 1440961 gggagtatgg ggatattagc gaatatcagc atgtttgtga aatattcaga gaataagaaa 1441021 aagaaagagc ccttggcgcc gaagggaatg aaaaagaaac agctcaaaaa aactgtttat 1441081 ctgtaaaaaa caagtgtgta caggggaagg atattccgct atgatagatt atattccatt 1441141 cgggtaaggg ggagaaaagt ttgtctcagc aatcgataca aaaagtatta gtagcaaaca 1441201 ggggagaaat tgcaatccga atattccggg cgtgtaccga gttgaatatt cgtacagttg 1441261 cggtctattc aaaagaagat tccggttcct accatcggta caaagcggat gaagcatact 1441321 tggtcggtga agggaaaaaa ccgattgatg cttacctgga tattgaaggt atcattgata 1441381 ttgcgaaaag aaacaaagtc gatgcaattc atccgggata cggtttctta tctgaaaata 1441441 ttcattttgc gagacgatgt gaagaagaag gcatcgtatt catagggcca aaatccgagc 1441501 atctcgatat gtttggtgac aaggtaaaag cgcgtgagca ggcagaaaaa gcgggaatcc 1441561 ccgtgattcc gggaagcgac ggtcctgccg aaacgcttga agccgtcgaa caatttggac 1441621 aagctaacgg ttatccgatc atcattaaag cctcgcttgg cggcggcggc cgcggtatgc 1441681 ggattgtcag atctgaaagt gaagttaaag aagcatatga gcgtgctaaa tcagaggcga 1441741 aagcagcctt tggcaatgat gaagtttatg tagaaaaatt aattgagaat ccgaaacata 1441801 ttgaggttca ggtcattgga gacaagcagg gcaatgtcgt ccatcttttt gagagggatt 1441861 gctccgttca aagacgccat caaaaagtca ttgaagtggc gccgagtgtc tcgctgtcac 1441921 ctgaattaag ggaccaaatt tgtgaggctg cagttgcgct tgccaaaaat gtaaactata 1441981 taaatgcggg gacggtcgaa ttccttgttg caaacaacga gttctacttt attgaagtaa 1442041 atcctcgcgt acaagttgaa cacacgataa cagaaatgat tactggtgtc gatattgttc 1442101 aaactcagat ccttgttgcc caagggcaca gccttcacag caaaaaagta aatattcctg 1442161 agcaaaagga catttttaca atcggctatg ccattcagtc acgggttacg actgaggatc 1442221 cgcaaaatga tttcatgcct gatacaggaa aaatcatggc ttaccgctca ggcggcggtt 1442281 ttggtgtccg tcttgatacc ggaaacagct tccagggcgc cgtgatcaca ccatactatg 1442341 attcacttct cgttaagctt tcaacttggg ctttaacgtt tgaacaggca gctgccaaaa 1442401 tggtgcgaaa ccttcaggag tttagaatca gaggcataaa aacgaacatt ccgttccttg 1442461 agaacgttgc aaagcatgag aagttcctga cagggcaata tgatacatct ttcattgata 1442521 caacgcctga attatttaat ttccctaaac aaaaagaccg cggaacgaaa atgctcactt 1442581 acatcggcaa tgtgacagtg aacggcttcc ctggaatcgg gaaaaaagaa aaaccggcgt 1442641 ttgacaaacc gttaggcgta aaggtagacg ttgatcagca gcctgccaga ggaacaaagc 1442701 aaattctcga tgaaaaaggt gcagaagggc ttgcaaattg ggttaaggag cagaaatctg 1442761 tccttttaac tgatacgaca ttcagggatg cccaccaatc gttattggca actagaatca 1442821 gatcgcatga tttgaaaaaa atcgcaaatc cgacggctgc gttatggcct gaactattca 1442881 gtatggaaat gtggggaggc gcgaccttcg atgtagccta ccgattcctg aaagaagatc 1442941 cgtggaaacg tttggaagat cttcgcaaag aagtgccgaa taccttattc cagatgttgc 1443001 ttcgctcatc aaatgcggtc ggctatacga attatccgga caatgtgatt aaagaatttg 1443061 tgaagcaatc agctcaatcc ggtattgatg tgtttcgtat tttcgacagc ttaaactggg 1443121 taaaagggat gacgttagcc attgatgctg ttagggatac cggcaaagtg gcagaagctg 1443181 cgatttgtta tacgggagat atccttgaca agaaccggac gaagtacgac cttgcatatt 1443241 atacatcgat ggcgaaggag cttgaggcgg ccggagccca tattctcggg attaaagata 1443301 tggcagggct gttaaaaccg caggctgcat atgagctcgt ttctgcgttg aaagaaacga 1443361 tcgacattcc ggttcacctt catacgcatg atacgagcgg aaacggtatt tatatgtatg 1443421 cgaaagctgt tgaagccggc gttgatatca tagacgtggc ggtcagctca atggcgggat 1443481 taacgtcaca gcctagcgcg agcggatttt atcatgcgat ggaaggcaac gaccgccgtc 1443541 cggaaatgaa tgtccaaggc gttgaattgc tgtcccaata ttgggagtcg gtgcgtaaat 1443601 attatagtga atttgaaagc ggaatgaagt ctccgcatac tgaaatttat gaacacgaaa 1443661 tgccaggggg ccaatacagc aacctgcagc agcaagccaa gggagtaggc cttggcgacc 1443721 gctggaacga agtcaaggaa atgtacagac gcgtgaacga tatgttcggt gacatcgtca 1443781 aggtaacgcc ttcctcaaaa gtagtcggag atatggcact ctacatggtg caaaacaatc 1443841 tgactgaaaa agacgtttac gaaaaaggtg aatctttaga tttccctgat tctgtcgtgg 1443901 agctttttaa aggaaatatc ggccagcctc atggcggatt cccagaaaaa ctgcaaaagc 1443961 tgatcttaaa agggcaggag ccgattacag tcagaccggg cgaactgctt gagccggtgt 1444021 catttgaagc gatcaaacag gaatttaaag agcagcataa cttggaaatt tcagatcagg 1444081 atgctgtggc atatgccctt tatcctaaag tcttcactga ttatgtgaaa acgacagaaa 1444141 gctatggaga catctcggta ttagatacac cgacattctt ctacggtatg acattaggtg 1444201 aagagataga agttgaaatt gagcgcggca aaacgctgat cgttaagctg atttcaatcg 1444261 gtgagcctca gcctgatgcc acccgcgtcg tttatttcga actcaacggg cagccgcgtg 1444321 aagtagtcat taaagatgaa agcattaagt cttccgttca ggaaaggctg aaagcagacc 1444381 ggacaaatcc aagccacatc gcagcttcca tgcctggaac agttattaag gtattggctg 1444441 aagcaggcac aaaagtcaat aaaggtgatc atttgatgat taatgaagcg atgaaaatgg 1444501 aaacaacggt tcaggcgcct ttctcaggaa caatcaagca ggttcatgtg aaaaatggtg 1444561 agccgatcca aacgggagat ctgctccttg aaattgaaaa agcataaaaa acaaagagtg 1444621 tatatcaatg atatacactc ttgtttttta tatagaaaat gtggagtgaa acagatggtt 1444681 agaagagata taaggggact tcagagatta tagagtactg tcacaagccc aaaataaaaa 1444741 gaggcttata cagccaatat tttagatgct ttgtagtatg ccgtgcatat ttctttaagc 1444801 actatctgat ttaaaaggct ttaatactta tgttcgcgag ctatagatcc atatgaaatt 1444861 tctataatca cgatgagaaa ggggacagac cgaagtgagc cgctcactga tcatcaagtt 1444921 cggcgaaggc tggcgattga aacgcataaa gcgccaaaaa acaagacata aaaaagacca 1444981 aagccgccta aggctttggt cttgagtcct tatgattgcc tggattcata acggaaacga 1445041 gcaatcaata ataagaagta gcatagaacg ccaaacagac aggcaataaa gaacgagtgg 1445101 gcaagtgcaa agcccagagc cagttcagag tatacgatca taataccgga cagtgcctgt 1445161 aatgtaatga aaataagaca tgagatccat ccccaaaaga tctgtttttg atctttatag 1445221 gaagtaatag catgaacagc ggcaacaata atccatacaa ataaaagtaa ggctgctgct 1445281 ctgtggccca tttgcaccca ttcatggaat tgggtcggaa gtccattgtt cagcgggctg 1445341 cacagcggca cattaggaca tgccagactt gattcagtgt gtcttacata tgcgcctgta 1445401 tacacaacga tataggaata tattaaaatt cctatcatgt gaaattgcat ctttttgccg 1445461 atttgaagcg gcttaaccag tgttctgact gatttatcag cttcaaatat gagcaatgtt 1445521 aaaataagca ctgaagcaaa agaaattaat gagatgccga agtgaagcgc cataatcagc 1445581 gcgttcgaac cgaatacgac agccaatgcg ccaagcaatg cctgaagaaa taaaaagata 1445641 attgacatga tcgcgagaaa cgttgtttca cgaaaaatcg gcgtgatttt tctccatgac 1445701 caaaacgcaa ggcttagcac aaggataata gagattccgc ttgcgaatcg gtggctccat 1445761 tcaataattg aagccggatt cagttcaggg aaaaaacggc cgtgacacag cggccactgt 1445821 ctgccgcatc cttggccgga acctgttttt gtaacgaggg cacccccgat taaaacaatt 1445881 agcatgacaa atgtcgtcag aacaccgaga gcttttaatg ctttattcat acaatattca 1445941 ccttcttaac atactgctgc aattttatat acgttccaag tgtaagcgaa tatgtgtttt 1446001 gtggcaattc ccagagcctt ttgttcacaa aaatataata gaatgacggc ttctggaaaa 1446061 tgtacacttg attattcatg ccgggtctga tagaaataag gtaaacgcaa tgccgatttg 1446121 gagattgcct tcatctttgg taaaattcat aaaaagttca caaataaatt cctgtttgtc 1446181 gtttaatatt taataggatg tttttttaca agatgttatc ttgtatgata gagttgcagg 1446241 ttattttatt ctcctgcgtt aggtttgtaa gggaggttta cgttatggct aactccagaa 1446301 tcttaaatga tacagctata gacggacaaa ttgaagaaac aacggcatgg aaagattttc 1446361 tgtcccttat taaaataggg atcgtcaatt ctaacctcat cacgactttc actggaatgt 1446421 ggcttgcact gcatatatcc ggtttaagtt ttttaggcaa tataaacacc gttcttctta 1446481 cgttaatcgg gtcttcactg attattgcgg gctcctgcgc gatcaataac tggtatgacc 1446541 gggacattga ccatcttatg gagcgtacga aagtaagacc gacggttacg ggtaaaattc 1446601 agccgagtca ggcgttatgg tctggaattt tgctggttgc tttaggattg atcatgctgc 1446661 tgatgacaac tgtcatggct gctgttatcg gttttatcgg agtctttacg tatgttgtat 1446721 tgtacacaat gtggacgaaa cgccgctata cgattaacac agtagtagga agcgtttccg 1446781 gtgcagtgcc gccgcttatt ggatggacgg cagtggaagg gaatatcggt gtcgtagcat 1446841 gggtgttatt catgatttta tttatttggc agattcctca cttcttagca ttggctatta 1446901 agaaaactga ggattacaga gctgcaaata ttccgatgct tcctgtcgta tacggatttg 1446961 aagtgacaaa aagacaaatt attgtgtggg ttgcgtgcct gatgccgctt ccgtttttcc 1447021 ttggtagcct gggtcttccg attgtcattc tcggcttgct gttaaatatc ggctggctga 1447081 ttcttggctt aatgggattc cgctccaaga atatcatgaa gtgggcaacg cagatgttcg 1447141 tttactcgct taactacatg acaatctatt tcgttgccat ggttgtcttg acgcttttct 1447201 aaaaaataga tatgatgctt gttttatcgc ttcaaaataa acgatgacaa ctagtaaatg 1447261 ccgccttgac ctcttgttta atcaggcggc tttactttta tacatagatg gcattttgag 1447321 taaaaaaact cataatttaa gagaagagga aatgtaagtg ctttattggt gataggttgg 1447381 atggcgatag atttcgatcc gctttccgcc tttgtattga ccagaaaagg ggttgggtga 1447441 aatggtaaag cattggcgtc ttattttatt attagcctta gtgccgcttc tattaagcgg 1447501 atgtggaaaa ccttttttat ccacgctcaa gcctgctggc gaggtggctg ataaacagta 1447561 tgacctgaca gtgctcagca cattgattat ggtggttgtt gttgcagtag tatctgttat 1447621 cttcttttat gtgattgtga gattcagaag atcacgggtc ggtgagaaca cgataccgaa 1447681 acaggtagag gggaataaat ttttagaaat cacatggacc gtgatcccga ttttgctgct 1447741 cattattctt gtgattcctg ttgtattata tacgctggag ctagcggaca catcaccaat 1447801 ggataaaaaa ggccgcaaag ctgaggatgc tcttgtagtc aatgttaggg caaatttata 1447861 ctggtgggag tttgagtacc ctgattacgg cattatcaca agccaggagc tgattgtacc 1447921 gacagatcag cgtgtatatt ttaatttaaa agcctctgat gtaaaacatt ccttctggat 1447981 tccttcagtt ggaggaaaac ttgatacgaa tacggataat gaaaataagt tcttcctgac 1448041 atttgattca aaacgaagca aagaggcagg agatatgttt tttgggaagt gtgcagagct 1448101 ttgcggccct tcacatgcgc tgatggattt taaggtgaag acgatgtctg caaaagaatt 1448161 tcagggctgg acaaaagaaa tgaagaacta taagtctaca gcagagagcg atttggctaa 1448221 gcagggtgaa gaactgttta aagagaaaaa ctgcctgagc tgccatgcgg tagagccgaa 1448281 tgataagcgt gcagaagccg ctagaacggc acctaacttg gcgaccttcg gtgaaaggac 1448341 aaaagtggca ggggtgaaag aggccaacaa agaaaatgtg aaggcttggc tgaaggaccc 1448401 tgacagcata aagccgggga acaaaatgac aggcacatat ccaaagctct cagacagcga 1448461 aacaaatgcg ctttatgaat acttaaaagg cttaaaagcg gaaagcaagt agggaagaaa 1448521 gggagatatt gggggaggtc acatatgttg aatgcgctta cagaaaagcg gacgcgcgga 1448581 tctatgcttt gggattattt gacgacggtg gaccataaaa aaatcgcaat tctttattta 1448641 gtggcagggg gattcttctt tcttgtcggg ggaattgaag cgatgtttat cagaattcag 1448701 cttgcaaagc cggaaaatgc gtttctcagt gctcaagcgt acaatgaagt aatgactatg 1448761 cacggaacga cgatgatctt tctggctgcg atgccgctct tatttgcctt gatgaatgcg 1448821 gttgtgcctt tgcagatcgg ggctcgggac gtttcgtttc catttttaaa cgcgcttggt 1448881 ttttggctct tctttttcgg gggcattttc ttaaatctaa gctggttttt gggcggagcg 1448941 ccagatgcgg gctggacatc atatgcctca ctttcgcttc attctaaagg gcacggcata 1449001 gactttttcg tcctcggact ccaaatatcg gggctcggga cgctgatagc cgggattaac 1449061 tttttggcca cgattatcaa catgagggct ccgggcatga cgtatatgag gctgcctttg 1449121 tttacatgga cgacatttgt ggcctcggca ttgattttgt tcgcgtttcc gccgcttacg 1449181 gttggattgg ctctcatgat gctggatcgg ctgttcggaa ccaatttctt taatccggag 1449241 cttggcggaa atacggtcat ttgggaacat ttattttgga tcttcggcca cccggaggtt 1449301 tatatcctaa ttttgcctgc attcggtatt ttttctgagg tcatccctgt gttcgccaga 1449361 aagcgtttgt ttggctattc ttcaatggtt tttgcaatcg tgctcattgg ctttctgggc 1449421 tttatggttt gggtgcacca catgttcacg actggtctcg gcccgattgc aaatgcgatt 1449481 tttgcggttg caacaatggc tatcgcgatt ccgaccggga ttaagatttt taactggctg 1449541 ttgacgattt ggggaggaaa tgtgaagtat acaaccgcta tgctgtatgc tgtctcattt 1449601 attccatcct ttgtgctcgg cggtgtgacg ggagtcatgc tggcagctgc tgcggctgat 1449661 tatcagtttc atgatacgta ttttgtggtt gcgcacttcc actacgtcat tattggcggc 1449721 gttgtattcg gccttttagc cggtgttcat ttctggtggc cgaaaatgtt cggtaaaatt 1449781 ctgcatgaaa cgatggggaa aatttcattt gtattgtttt ttatcggctt tcacctcacg 1449841 tttttcattc agcattttgt cggcttaatg gggatgccgc gccgggttta tacgtttttg 1449901 ccaggacagg gtctggaaac cggcaacttg atcagtacaa tcggggcgtt ttttatggcg 1449961 gcagctgtta ttcttctgct ggtcaatgtc atatggacat cggtaaaagg tgaatatgta 1450021 ggtgctgatc catggcatga cggacgtacg ctggaatgga ccgtttcttc accgccgccg 1450081 gagtataact ttaaacagct tccttttgtc agaggacttg atccgctttg gatcgagaag 1450141 caggcagggc acaaatcaat gacgccggcg gaaccggttg atgatattca tatgccaaac 1450201 ggctcaatcc tgccgctcat catttccttc ggcctttttg tcgcagcgtt cgggctgctg 1450261 tacagaagtg attacgcttg gggcctgccg gtgatcttta tcgggctcgg catcacattt 1450321 attacgatgc tgcttcgttc agtaattgat gatcacggct atcatattca taaagaggaa 1450381 ctgccgaacg atgataaagg ggtgaaggca taatgcaagt tcaagaaaaa ttcaccgcag 1450441 aaacctttcc agcttctcct gaaaaagtaa ccctggaagg gaaaaataaa tttttaggct 1450501 tttggctttt tcttggcgga gagactgttc tgtttgcgtc tctcttcgcc acgtttcttg 1450561 cgcttcggaa ttcaaatgcc ggtgatccgc ctacgacgga aatgttcgat gtgacacttg 1450621 tattcattgc cacaatgctt ctattaacga gcagtttaac gagtgtgtac gcgatgtacc 1450681 acatgaagaa cttttccttc ggcaagatgc agctttggct gggaattacg attttattgg 1450741 gggcgggctt tttaggactg gaaatctatg agttcaagca ttacacccat gaatttggct 1450801 ttaccatcac aagctctgcc cttggttctg cgttttacac gcttgtcggt acacacggcg 1450861 cccacgtggc atttgggctt atgtggatca gcacgcttat gatccgcaat gccaagagag 1450921 ggctgaatct gtatacggcg cctaagtttt acgttgccag cctttattgg cactttattg 1450981 atgtcgtgtg ggtcttcatc tttaccgttg tatatttaat ggggatggtg ggataaacat 1451041 ggtcgataaa aaaagcagag ggcatatcaa tagcgacctt gaatttaaga aaaaaaagca 1451101 tgcccgggag atgaaatatc aagtcctgtc ttttggttta atgatcggtc ttacgattgt 1451161 tgcatttctg actgtggcca cggacggtgt cggcagctgg tttacgattc ctttcattat 1451221 tttgctagct gcaattcaag tcatttttca gctgtattat ttcatgcata tgaatcagaa 1451281 agggcatgag gcgccggcac tgtttttgta ttcaggggtg tttgtcgcgt ttatcactgt 1451341 gcttgcgttt gtgacaatta tatggtggta atttgaacag ccgccggagg tgaagaaatg 1451401 aatcagttgg agatatttgg gtttcgcgcg atgtggagcc cttatctttt ttgtatcctg 1451461 ttaggcatta cggcgcttta tctctatttt tacaggcgaa tgtcttcaaa gccgaatcga 1451521 ataactggta aagagatggt gtgctttctg tcggcgatgc tgtttttata tgcagccgag 1451581 ggaagcccgg ttgatctgct cggacatatt atgttcagtg cgcatatggt gcagatggcc 1451641 gtcctgtatt tggttgtccc gccgctgtta atcgcgggga ttcctgcatg gctctgggaa 1451701 aaaatcattt tcaggccttc aatcaaaccg gttttttcct tttttacgac gcctttaatt 1451761 gctttgcttt tgtttaacgg cattttttct ttatatcatg taccgcttat atttgatact 1451821 gtcaaaacag atccgtttta ccatacatta atcacttggc ttatctttgt gcttgcgttc 1451881 ttcatgtggt ggccgcttgt tcataaggtt gagcgtctac ggcagctcag cggcttgatg 1451941 aagctgggtt atattatggc ggacggtatg ctgctcacac ctgcttgcgc cttgatcatg 1452001 ttcagcggtg caccgttata cgccacctat acagatccgg ctttatgggc tgaggcaatg 1452061 aggctttgcg tgccagcgga tatgatgggg caggtcccat taacagggcc agagatgttg 1452121 aatacactgc ctttgttaga ggatcagcag ctcggagcag tcatgatgaa aatcattcag 1452181 gaaattgtgt acggtacttt tttggccgtt atttttttcc aatgggtgaa gaaagaaagg 1452241 gaaaaggacg ggcaggagga gccgccgtat attcagcaga cgatatcata aaaggtacag 1452301 cgaaatatgc tgtacctttt cgttacattt gaactgtttt taacatgttg gctatgtcct 1452361 gaatcagtgc cttgcttttt gtcacaacct gtacgggaaa ctcttccgtt tctccatatt 1452421 ctactccatg agggtagtaa tgctttccta ggagagggga cattaattga atcacggcgc 1452481 gcccgcttcc gacatcgcct tctgccgcaa taccttgtat ccgcaggtaa aacgtaccct 1452541 caatcgtcga aaacttcttg tcataggtga ctctctcgta atcccattga cccgctctga 1452601 taagaccttt gctttccatt aagtcgtcta gccagctgag ctcagcctta accccttcaa 1452661 gtccgctttc agtaaacttc aacactgacc cctccttata aaaattacct ttcctgacaa 1452721 tcatagtatg aaagcgttaa actttcaatg aatcttcttc ttttgaaagt atgcaaaaat 1452781 taaattttga cgacaatagc actagactaa aggaggttaa acggatgaca aaaataaaag 1452841 atctgatgac agccgacttg caatattgca cggtattaga taatgtatat gaagctgcag 1452901 taaagatgaa ggacgcaaat gtaggagcga taccggtagt tgatgaggac ggggaaacat 1452961 tggtcggcat cgtaaccgac cgcgatctcg tattaagagg aatcgccatc aaaaaaccga 1453021 actcgcaaaa aatcactgac gcgatgactg aaaaacctgt cagtgtggag gaagatgctt 1453081 cagtcgatga ggttcttcat ttgatggcat cgcatcagct cagaaggata ccagttacaa 1453141 aaaataaaaa actgactgga attgtcacgc ttggtgatct ttctttatct gagcaaacga 1453201 atgaacgtgc cggcagcgcc ttatcggata tttccgaagg ggataataga gaagaaggct 1453261 tttttcatta acacataaat ctttgacatg ttaaataggc tgtattgtaa tgggatgtaa 1453321 acaagagatt gtgaatcgcc acgggggtga tagattgaaa aatatattga gagcaatggt 1453381 tatccttttg attatctgcg gaacctatgt tctgtttatt caatatggat ctgttcctga 1453441 aaagaaatca aatgacagcg agcctcaggt gtcgaatgag gaagcgcaaa gcggcaaacg 1453501 aatacatatg ccgacttcag ggttattgtc cttcatgggc aagcacgccg atgaagtaac 1453561 gaaaaagctt ggggaacctg aacgtattga cccttcggct tatgattacg attggtgggt 1453621 atacaatcaa ggtaaggatc aatatatcca aatcggggta ttaaacaata aagtggtcac 1453681 attattcgcg tcgggtaatg atattaacgc caagcctttc aaaattggag aatcaactgg 1453741 cgaagtattc aagaccaccc aggtggcacc atttgtgaat gtagagtata aaggaaattc 1453801 ctatcggttt gaattttctg aagaagatat caatacaaga ccgactgtaa aggtaggaaa 1453861 gatgtatgtc cagctgtata tggacaaatt tgaggggaag ctatccagca tcagggcgtt 1453921 tgatgcgcag acctttgtaa agcaaagacc ttatgaggta gtgtaccgcg gggaattaat 1453981 taaaccgaaa gccgtttcag atgagaaatg gaaaaagatc caaacaacga gcgaaaagca 1454041 aatccttgat ttgacgaatg tcatacgcgt taaacatgga cttgcgaagc ttgagtggga 1454101 tcagccaacg gcggaagtgg catttgggca tagtgaggat atgaaggaaa ataattattt 1454161 ctcccatgtc tctaaaaaat acggctcgct gaaagaccgc ttagaagaag ggcatgttga 1454221 ttttcagcaa gcgggagaaa atatcgcata caattatgtg gacggtccgg ctgctgtaga 1454281 aggctggctg aatagcgaag gccatcgaaa agcgcttctg aattcagatt atacgcatct 1454341 tggtgtcgga gtagaccgga aatattacac ccaaaacttt attaagcgat ggtaatgaaa 1454401 gccgcggacg aatggttccc ggctttttct atttccatac aagctggtct gaatgaatgt 1454461 gctgatagct tacagataag gccgtttccc atcccttcag tcaggctttt tcaccagtgt 1454521 atagggatat cgctaaaaat tcatttggga atgaatatag gcgaacacaa tgcccgacaa 1454581 aacgatacat tgtagtaggt aacgattttc ggagggggtg aggattgtgg cgaatcaaca 1454641 tgccaatcat tcaatcaatg actttaaaca attcgtcaaa aagcatccca agctgataaa 1454701 agaagtgcgc aaagaacaaa gaagctggca ggacgtatat gaaaattggg tcctcttcgg 1454761 ggagagcgac ccgatttggg atccatatcg ggaaccggaa gaagcttctg aagctgtgcc 1454821 tgaaacaccg caaaaaaatg attttgtctc gaaaatggtg acagcggtga aaaagatgga 1454881 tgtcaatcaa atgaacgaac aaatcaataa aatgagccag tcgatctcat cgttgcaaag 1454941 ccttcttaat acattttccg gaagcggaca gaagcattct cagccaggct ctggacagca 1455001 tcctttttct tttcgaaagg attaaaaaag gggagctcat atgcgcaaag aggttcagga 1455061 atatatttta gcaaacgaag aacggaaacg attcatcaga gaacagccga tatggtaccg 1455121 caggctttca agaaaaccgg atgatctgtc ctcctttcag cttgaaatga tgaattttta 1455181 tgaaaaaacc attccgcatc gggtgaatca gtttacgaac gggattcaaa tggcgcaaat 1455241 gatgatgcaa atgtttcaag cgatgcggac aaaagattaa aaggccccga agaagggtct 1455301 tttttcatgc ggtcataagg ttttgttggc ggctgcggtt aagcattttc caattggctg 1455361 gtttcatggt aaactaacaa ctggaggtgc atgttatgta tgcgacgatg gaatccgtgc 1455421 ggcttcaaag tgaagctcag cagcttgccg agatgattct gcagtcggag acggctgaga 1455481 actaccgcaa ttgttacaag cgtctccagg aagatgaaga ggcaggtcgg attattcgtt 1455541 cttttatcaa aataaaagag cagtatgagg atgtacagcg ttttggcaaa tatcatcctg 1455601 actatagaga aatatcccgg aaaatgaggg agatcaaacg tgagctggac ctgaacgata 1455661 aggtggctga cttcaagaga gctgaaaatg agctccagtc cattcttgat gaggtcagcg 1455721 ttgagattgg gacagctgtt tcggagcatg tgaaagttcc gactgggaac ccttattttg 1455781 acggtttgtc ttcatgcgga ggcggctgcg gttcaggcgg aagctgcgga tgtaaagtgt 1455841 cctgacgaga ctggccgtct cgtcttttac atataagaga aaacaggcag gtgattgtat 1455901 tggagaatag gcgccagggc atggttgtgt atctgcactc cctaaagcag agcaaaatgc 1455961 tgaggaagtt cgggaatgtg cactatgtat caaaacgatt aaaatatgtc gtactgtact 1456021 gtgatatgga ccaaattgaa aaaacaatgg acaagattgc gtcttactca tttgtgaaaa 1456081 aagtggagcc ttcttataaa ccgtttttaa aattggaatt cgagtcaaag cttgataagg 1456141 caaaagaata cgattataaa atcggcatat agctataaaa aaatccccgc aggcatctgc 1456201 ggggtccttc tattccttaa tatgttaagg agaaggcaaa gggagaggag aaaccggagg 1456261 aagaacttat ggggaaacgt aagtcttctc cgcggttggc aacaacatcc tctagatgct 1456321 gttgcttata gtatggacaa ggatcatgct gcctatacac ctgtttatca agattagcgt 1456381 tcattgtttg gaagaatgct ttatgttaag ataggattga tttttttcta tgtacatagc 1456441 ggcgtccggc cgaataaaga aacaaaatag cttttagaaa aagtggtgtg gaacatgaga 1456501 gtaatttctg gatcaaaaaa aggccgttca ctaaaggctg tagccggaac atcaacaaga 1456561 ccgacaaccg acaaagtgaa ggaatccatt ttcaatatga tcggccctta ttttgacggg 1456621 ggcaggggac ttgacttatt cgcagggagc ggaggtcttg gaatcgaagc gctttcacgc 1456681 gggtttgagc attgtatatt cgttgaccgt gattttaaag cgattcaaac ggtaaaatct 1456741 aatttgaaaa cgctggagct tacaaaacat gcacaggtat accgcaatga tgcggaacgt 1456801 gctttgcacg ctgctgctaa aagagaaacc ggctttcgcg gaatttttct cgatccgccg 1456861 tataaggaac aaaagctgaa agcactttta actttgattg acgaatatca aatgctggaa 1456921 gaagacggct ttatcgtcgc tgagcatgac agagaggtcg agcttcccga aaccgtagga 1456981 gatcttgtga tgacaagaaa agaaacctat gggttaacag gtgtagcgat ttataaaaag 1457041 agggggtagt gaggtggcga gtatagctgt ctgtcccggc agttttgatc ctgtgaccta 1457101 cgggcatctg gacatcatca aacgcggggc gcatattttt gaacaagtgt atgtatgtgt 1457161 gctgaataat tcttcaaaaa agcctttgtt cagtgtggaa gaacggtgtg agcttctgag 1457221 agaagtcaca aaagacattc cgaacataac agttgaaaca tcgcaaggcc tgttaattga 1457281 ttatgcaaaa agaaaaaatg cgaaagcgat tttaagaggc ttgagagctg tatctgattt 1457341 tgaatacgag atgcagggga catcagtaaa ccgggtgctt gatgaatcta ttgagacgtt 1457401 ttttatgatg acaaacaatc aatattcgtt tctaagttca agcatcgtaa aagaagtggc 1457461 aagatacaac ggctcggtat cagagtttgt accgccggaa gtagagttgg cgcttcagca 1457521 aaaattcaga caaggatgag ggttttgact catccttttt ttgttccgtt tgtcagtctg 1457581 taagaaaaaa tgataatgta cgtaaacagc gcgcatagtg tgacagcagg tccgatctgc 1457641 acaagcagat tccagccgtt tataaaggca gttgacatgt cactgctgtt aagagattta 1457701 aatacatact gatacggatc atgccatgct gtgtaaagag gtttccataa aagcatgacg 1457761 aagacagcgg cataaacgcc ctgcagcaaa cgtgcgataa agaatggttt aaatctaatg 1457821 tcggtttccg ataaaatacc tgccacctga gcttgtacgg aaaagccgct aaacccaaga 1457881 ataaagctga cgataatggc tttttgcaga agagaaacat ctgtctcgct gacaagcttg 1457941 ctgcctaatg taatttcaaa catccctgat aaaagcggaa tgtccaattg agtcggaagc 1458001 tgaaacaaag tcagtgctcc ttttgtgaaa acagacaaaa catcagtcag ctggaccact 1458061 gacaacagcc gattgaagac agaaaataaa ataataaagc cgcctaccat aagaagcgtt 1458121 tgaacagaag acgtcacggc gtcgcctaaa attttaccta agggccgttt ttctgcaagt 1458181 ctggcggtat gaagagcgtg taaagcatct ttgactgaag ggaaaggtat cgttttcttt 1458241 cttctgagat gctgctcttc cttgcggcca taggagcgca ttgttaaacc gacggcaaga 1458301 ttccccaaat agtgtgcaga agctaataaa atgcctagtg atgcgttttg aaagaaaccg 1458361 acggcaacag cgccgaaaat aaagagcggg tttgaagaat tggtaaacga cgcgagccgt 1458421 tctgcctcta ctcttgaaat ctgattttcc tgccgcagac gggcagtgag ttttgcgccc 1458481 gctgggtttc ctgatgccat tcccatagca agaacgaagc cgccgacacc cggcacgcga 1458541 aagatcggcc gcataaaagg ctcaagcaaa acaccgacaa accgcacaat gccaaagccg 1458601 attaagagtt cggacagaat aaaaaatggc agcaatgacg gaaacacaac ctcccaccac 1458661 atagacagcc cggttttaga ggcttcgaat gaggcctgtg gatgtgagat gacagtcgct 1458721 gttaaaaaaa gaaaaaacga ggcaatcaaa agtgtattaa tcttcgacaa gttcattctt 1458781 acctccccga tgctaaaaat gcccaatgac atgtatatca tgataaaata atgtatgatg 1458841 taaaacggcc aagcagtacc tgtcctcttg attctttgta ctaatatacg agcatagggg 1458901 ttcagtttag accatagaat tcggtataca gggaattcag gcaggaggtt aacgctttgg 1458961 ccaaacctaa aatcgggtta gcgttaggat cgggaggggc cagagggctt gctcatctcg 1459021 gtgtgctttc cagtttacat aagcaccaaa ttgaagtgga tatgattgca ggaagcagca 1459081 tgggcgcttt ggtgggcagt ttttacgccg ccggacatga cgtggcaacg atgaaaaaag 1459141 tagccaaagc ctttaaacga aggctttatg ctgattatac ggtgccgaaa ctcggttttt 1459201 taaaaggtga ccgcgtcaga cagcttgtgc atgcttatac attcggaaaa ccgattgaag 1459261 agctccaaat cccgctgggc attgttgcgt gtgatctaca gacgggagaa aagattgtgt 1459321 tccgaaaagg atcagtgtca gatgcagtga gggccagcat cagcatcccg ggtatcttta 1459381 ttccgcagcg gctggacgga cgccttcttg tagacggcgc ggtcgtcgat cgaattccgg 1459441 tttctgttgt gaaagacatg ggagctgata ttatcatcgc ttcggatgtt tccagggttc 1459501 gaaaaactga aacagcagtg catatttttg atgtgattat gcaaagtatg gatatactgc 1459561 aaaatgaatt agtgcggcat caaacaattg ccgcagatat catgattcgc ccttcccttg 1459621 aaacatacag ctcaagctcg tttgccaata ttgaagaaat gatatcggca ggcgaagagg 1459681 cgacaaaccg aatgatcagc aagataagaa aagaaataga gaattgggag ggctcataat 1459741 ttgctacgta aaaaacattt tagctggatg ctcgtcatcc tcatactgat cgccgtttta 1459801 tcatttataa aacttccata ctatattaca aaaccgggag aagcgacaga gcttgcttca 1459861 ttgataaaag tggagggagg ctacccggaa aaaggaagtc tgtccttaat gactgttaaa 1459921 gtgggaccgg ctaatccatt tacatatgtg tgggcaaaga tgcaccctta ttatgaaatt 1459981 gttcctgatg agagcattaa ggaggaaggc gaatcagata aggagtatat gaaaagacag 1460041 ctccaaatga tgaaaagctc gcaagaaaat gcggttatag ccgcctatca aaaggcagga 1460101 aaaaaagtca gctattcctt taacggcata tacgcaagct cagttgtaga aaacatgccg 1460161 gcaaaaggga aaatagaagt cggtgataaa atcatcagcg cagacggcaa aaactatcag 1460221 tctgctgaaa agctgattga ttatatcagc agcaaaaaag cgggagataa agtcacgtta 1460281 aagatcgaaa gagaagaaaa agaaaagcgt gtcaccctta cgttaaaaca atttcctgat 1460341 gagccggatc gggcaggaat cggagtttcg ctttatacag acagaaacgt gaaggtagag 1460401 cctgatattg attttgaaat cgaaaatatt ggcggcccgt cagcagggtt aatgatgtcc 1460461 cttgaaatct ataatcagct gacaaaacca gacgaaacaa aaggctacga tattgcggga 1460521 acaggtacga ttgatgttga cggaaaagta ggcccgatcg gcggcattga tcaaaaagtc 1460581 gtcgccgcag acaaagccgg aaaagacatt ttcttcgcgc caaatcaaaa cggcgccagc 1460641 aattccgatt ataagaacgc agtaaaaaca gcaaaagata ttgattcaaa tatgaagatt 1460701 gtgcctgttg ataccatgca ggatgcgatt gattatttga ataagctgaa agcgaaaagc 1460761 acctgattct caggtgcttt ttctatacat ttaaaaagtg ttgttcatct tcgtcatatc 1460821 gaatcggtgc atgtccgtat tcctgtaggt caaactcagt tctcagcggc tcttctatcg 1460881 gcaggctgta aatcctgctt gcttttacgt ccagatcgag agctggatgg gagaaagagg 1460941 acagtttgct gacaagcgga acagacagtg cttttttctt ttcggataaa taagcctgtc 1461001 cttttttcgt catgccgaga agcctgatat acggcgcctt atcgttgtca agcagctttt 1461061 gcatatcctg tttttttgtt ctggttaaaa tgtgtgtatt catccgctgg agccttgtcc 1461121 acgtatagcg ttttgttttc agcagttcca taaattcctg ataggagctg gattttctga 1461181 tcgaacgaat aattctgtgc tctaaacctt cctccacctc gtatacttgc tgtaattccc 1461241 gtgccgttac agttgaaagg ctgtatttta agtaagaaaa gtagctttca ggtgtatgcc 1461301 acaatccgaa agatttgcgg taagctgcta attcacgtgc agatgcagca gggagaaaac 1461361 gaaggcaggc ttcgagattc tggccaatca tcgcttttct aatgcttgtg gcacttgcta 1461421 tatggttttc gccttcaggg agatcggcat catgatagtc cgaagagatt cgtgccgtag 1461481 tataaggttt cataggatat cccccggtta gaatcgaggt cacatactgg tatcccaaaa 1461541 tgttatttgg ttttgacaag tcaagtgcac tttcagtatg caaaatggag ctgaaggcga 1461601 tagccgccgc tgctgggtaa ctggccccct ttttaagttc ttctttaatt cggtcattca 1461661 atatatgttt atgctcatca ataagctgtg ctgtttctaa aaaaggcttg atatccccat 1461721 tttcactccc gaaaaacagc gcctcacatt caagttcgtt caggatggaa acactgccgc 1461781 gtgcaaaaat gtctgctttt tgcacggcat aaagataagg cagctcaatg acaagatcaa 1461841 ctccgctttg cagcgccatt tttgttcggg cccattttga tacaacagcg ggttccccgc 1461901 gctgtaaaaa atgtccgctc atgaccgcga cagccgtgtc acatccggtt tgcagctttg 1461961 ctgtttgggc atgataaagg tgaccgttat gaaagggatt atattcaacc accaatccga 1462021 cagctttcat attttttccg cctttcttgc tatgtttaaa aacgtatggt acatttgcaa 1462081 atgaaaactc ttacgcctta tttttgtttt aagtgtatgc atagcatatt ccgctgtcaa 1462141 cgatacttca atggcagcat tatgctgtaa agaaaaaata ttgacaaaaa caatcttaaa 1462201 agctataatc atgtttgttg ctttcctgag gtgatacaaa tgaaatggac gatttatcag 1462261 ctgcatcaaa tgccaaaaca aagttttgag tttgatgaaa cagttgagtt aaatgagctg 1462321 acaaagctga attctgacat tcgccgcatt tctcccgttc gggtgaaggg cagagcggat 1462381 atcaaatcca aacaggtttc gtttgatttt acaatttcag gcgaaatgct tttgccatgc 1462441 tcaagaacac tcgttgatgt tccgtatcca tttgaaattt caacaaaaga actgtttata 1462501 tttcatcaca cggatgatat agaagatgat gacgttcaca ttgttgagga cgatactatc 1462561 gacataactc cgatcgtgaa agaagaaatt cttttagaaa tccctatgca aatcttttgt 1462621 gaatctgaac aagaaaaagg agctgctcct caagaaggaa aggattggca agtcatttcg 1462681 gaagaagaca agaagaatca agttgatccg agacttgcag cccttgaaaa gctcttaaaa 1462741 caagatgatg aatcttaact ctttaaggag gtgggaataa tggctgtacc ttttagaaga 1462801 acttctaaaa tgaagaaaag attgcgccgt acacatttca aacttaatgt acctggtatg 1462861 acagaatgtc cgtcatgcgg agagatgaag ttgtctcacc gtgtatgcaa agcatgcgga 1462921 tcatacaacg gcaaagacat aaatgtaaaa agtaactaat gagaaaagcg cagggtgaaa 1462981 gccctgcgct ttttcttttt ctcttcctgt cagcttgcgg aaaatttgtg agtgcaaata 1463041 gtctatctaa tctattaccg gcatatgtat gagataaata agctgacatg gagggagatt 1463101 gaatttgacc attacaagac aagatgcttg gactcaggat gaggatttgc tgctggcaga 1463161 agtggtgctt cgtcatattc gagagggagg aacacagctt tcagcctttg aggaggttgg 1463221 aagggcgctg accagaaccg cggcagcctg tggtttcagg tggaactcgt atgtgagaaa 1463281 acaataccag tcaggtatag agcttgcaaa aaagcaaagg aaagaactga gaaagcaaat 1463341 cggcgttcat tcggtcaata tgccgaattc catgaagcag actgcctcgg catcgtcaga 1463401 aggaaaacga gatttgtcca ttcaggatgt cattcaattt ctcgaacaat tcaaagaaac 1463461 accgtctgca caagaatttc agcttgaaag ggaaaaattg aaggagcaaa tccaatcgct 1463521 gcaaaaagag cttgaggatt tgcggagtga aaatcagaca ttgcggaatc agctagagat 1463581 gacagaagag gattacaagg cactgatcga tatcatggat cgggccagaa aaatggttgt 1463641 ttcgaaggaa gacggaagaa tgaaaaaagc ggctcaagaa acgtaaagaa acgcctgaaa 1463701 tgaaccggcc ctatagtaag aataggccgg ttgttttgat ttctatgcag actctcccgg 1463761 tgtcatttcg cgatccatat caggatgcca gatgagcggg ttttcccctt tgtcccgcgc 1463821 catatcatac ttaacagttt taaagttcat tttgttccaa aattccgctg atttcattct 1463881 cggatttgtc cggatcggca ttttgaatga ttttgcaaat tcaaccaagg ctctcccgta 1463941 tcccctgttc tggtagcccg gaagaacctc aagcttccac agctccaaat aatcctggcg 1464001 gttgtcaaaa tagggattcg atttgccgtt aacttgatac agactcattc gtgctacaag 1464061 tttatcgcca aaataaatcc cgtaaaaagg cgaggtgctg tcattttcaa taatattatc 1464121 ctgaagttct tcaagcattg aaagctcctg aatgccgtat tctttgaatt tcttgaattc 1464181 ttccagcgtt ttatagttga taagcagacg ttctaccttt gtcaaacaaa tctccccctt 1464241 tgttgtttct acatatattg taaacgcttt atttaaaaaa tccaaatatt taaactttaa 1464301 ttttaagcac atgggatctt tgagaagtaa tttcttctta cttctgctat gataatacgt 1464361 aaatgctaaa ttgggtgtga catcatgaaa attggaatta tcggcggagg ctccgttggt 1464421 cttttatgcg cctattattt gtcactttat cacgacgtga ctgttgtgac gaggcggcaa 1464481 gaacaggctg cggccattca gtctgaagga atccggcttt ataaaggcgg ggaggaattc 1464541 agggctgatt gcagtgcgga cacgagtatc aattcggact ttgacctgct tgtcgtgaca 1464601 gtgaagcagc atcagcttca atctgttttt tcgtcgcttg aacgaatcgg gaagacgaat 1464661 atattatttt tgcaaaacgg catggggcat atccacgacc taaaagactg gcacgttggc 1464721 cattccattt atgttggaat cgttgagcac ggagctgtaa gaaaatcgga tacagctgtt 1464781 gatcatacag gcctaggtgc gataaaatgg agcgcgttcg acgatgctga accagaccgg 1464841 ctgaacatct tgtttcagca taaccattcg gattttccga tttattatga gacggattgg 1464901 taccgtctgc tgacgggcaa gctgattgta aatgcgtgta ttaatccttt aactgcgtta 1464961 ttgcaagtga aaaatggaga actgctgaca acgccagctt atctggcttt tatgaagctg 1465021 gtatttcagg aggcatgccg cattttaaaa cttgaaaatg aagaaaaggc ttgggagcgg 1465081 gttcaggccg tttgtgggca aacgaaagag aatcgttcat caatgctggt tgacgtcatt 1465141 ggaggccggc agacggaagc tgacgccatt atcggatact tattgaagga agcaagtctt 1465201 caaggtcttg atgccgtcca cctagagttt ttatatggca gcatcaaagc attggagcga 1465261 aatacaaaca aagtcttttg agctttttcg gtaacatgct atactcattt cggatcacta 1465321 actatttatt ggagaaagga agttctagaa gatgcagcta actgaacttt ccatcaaaaa 1465381 tcagaatgtg tttgtacagc actatataga tggcaaagaa gaaatgtctt ctttttttga 1465441 ttacagtatt catcataagg acatgtggcg cgaaagactg gaagacttat cttcccggtt 1465501 tttcgcaaga gaggaattgg cggcgtactt aacctcttac cataataaat tcggttcaag 1465561 tgcgatgcag tctgctattg agaagctgaa ggacccgtca agtgccgctg tagtcggcgg 1465621 acagcaggca ggacttttaa caggaccgct ttacaccata cataaaatca tttcaatcat 1465681 tgttttagca aagcaacaag aaaaggaact gcaagtgcct gtcataccaa tcttctgggt 1465741 ggctggagaa gaccacgatt tggatgagat taattttgtt cacacatctg aagagaatgg 1465801 gcctgtgaaa aaaaagctgc ctcagtctta ttggaagaaa tcatcagcag cgagtacatc 1465861 gcttgatcag gaaaagtgtg ccgcgtggat agatgatgtt tttgccgctt ttgaagaaac 1465921 agaccatacg aatacacttc tcgacaatgt gaaacgatgt ttaagggaat ctgttacgtt 1465981 tactgacttc tttgaactgc tgatcgcgga tttgttccaa gaagagggct tagttttatt 1466041 aaattctggg gatccgggga ttaaaaagct ggaaacggcc atgttccaaa agattcttcg 1466101 agaaaatgat gaactcgccc gggctgtatc agatcagcag gccttcatgc gtcaagcagg 1466161 ctacaaaccg attatcgagt ccggaaaaga gcaggcgaat ctgttttatg aatacgaaga 1466221 tgagcgtttt ttaattgaaa aagataacgg ccgatttgtc atcaaagagc ttgatctagg 1466281 atggacgagg gatgaacttc atacacatat ggaagaacat ccagagcgtt tcagcaacaa 1466341 tgttgtaacg agaccgttaa tgcaggaatt tctcattccg actttagcat ttattgcagg 1466401 gcctggggaa atcaattatt ggggcgagct caaacaggca tttgcggtga tgggcttcaa 1466461 aatgcctcct gtcatgccaa ggctgaacat tacgatactt gagcggcata ttgagaaaaa 1466521 actggctgaa cggaatatct cattacaaga cgcgattgag cgcggaacgg agaatcaaag 1466581 agagacatac ttcgagcgcc agattccgga agagtttacg gcggtgatgg atcaggcgaa 1466641 aagccaaatt gaagcgattc acaaaacggt ccggcaggag gcgttaaagg ttgatcaaag 1466701 cttggaacct ttacttctga aaaatgccgc ttttattcag gatcagcttc aattcttaga 1466761 gcgcacggtg atgaagcgaa ttgaagaaaa agaaggctac gtcttgaagg attatgaaag 1466821 aattcaaaat agcattaagc cgcttcttgc gccgcaagaa cggatttgga atatcatgta 1466881 ttatttgaac aggtacggtc caaaattctt cacgacattc aagaatctgc cattttcttt 1466941 tcaaaatcaa catcaagttg tcaaactttg aaataaagtt ttaaagaacc ctgactagtt 1467001 cagggttttt ttttatgggt aaacagtgta aaatgaagtt gtggagcgaa gtggtgaata 1467061 gtggtgagtt aaggagagaa agtggggcaa gagatcatgt ttatgggtga atatcagcat 1467121 accatcgatg cgaaaggccg catgatcgta cccgctaaat tcagagaagg cctaggtgag 1467181 caatttgtgc tgactagagg acttgaccaa tgtctcttcg gctaccctat gcacgaatgg 1467241 aaacaaattg aagaaaaact aaaagctctt cctctcacaa agaaagatgc ccgcgcgttt 1467301 acccgtttct tcttttcagg ggcgactgaa tgcgaactgg ataagcaagg cagggtaaat 1467361 atcgcatcat ctctattgaa ttacgccaaa ctggaaaaag aatgtgttgt tatcggggtt 1467421 tctaatcgaa ttgaattgtg gagtaaagta atttgggaac aatacacaga agagcaagaa 1467481 gattcatttg ctgaaattgc tgaaaacatg attgggtttg atatataatg attcttcgtg 1467541 tataacactc taaaaacaat ttcaattcat cctgataaaa ggtgggacca acacaatatg 1467601 tttcaacaca agacagtact tcttcgtgaa accgtagacg gacttaatat taaaccagac 1467661 ggtacatatg tagactgcac actcggcgga gctgggcata gtacatactt attgcagcag 1467721 ttatccgaga aggggcgttt aatcgctttt gaccaagatg atacggcatt acagcatgct 1467781 aaagaagtgt tgtccgatta taaaggacag ctcattctga ttaaaagcaa tttcaggtat 1467841 ttaaaagaat atttgaatga acaaggcgtt acagaagtag acggcatttt atttgattta 1467901 ggggtgtcct ctccgcagct ggatacaccg gagcgcggat tcagttacca tcatgacgca 1467961 ccgttggaca tgaggatgga ccagtcggct acgctttcgg cgaaagaagt cgttaatgag 1468021 tggcgctatg aggatctcgt ccgtattttc tttaaatacg gagaagagaa gttcagtaaa 1468081 cagatcgcca gaaaaattga ggaggcaaga atgaagtctc ctattcaaac tacgggccaa 1468141 ctggtcgatc taataaaaga cgcgattccc gctccagcga gaaggagcgg gggacatccc 1468201 gctaaacgcg tgtttcaggc aatcagaatt gccgtaaacg atgaacttag ggtgtttgaa 1468261 gaagctttgg agcaggcaat tgaggttctg aagccagggg gcagggtatc ggtcattacc 1468321 ttccactcgc tagaagacag aatttgcaaa accactttta aagaaaagtc gtcgcttccg 1468381 gaacttcctc cgggacttcc tgttataccg gaagagtttg aaccggagct gaagctcatc 1468441 acacgaaaac cgattacggc atctcaagaa gagcttgaag agaacaaccg ggctcgttct 1468501 gccaagcttc ggattgctga aaaaagaaaa taacgaaacg cgaacgcaaa attaaaagga 1468561 ggtcatcagc ctatgagcaa tttagcttac caaccagaga aacagcagcg gcatgcgatc 1468621 agtcctgaga aaaaagtgat tgtcaagaaa agggcttcca ttactctcgg agaaaaagtg 1468681 cttcttgtcc tctttgctgc ggcggtgctc agcgtatcgc ttttgatcgt atcgaaggcg 1468741 tatgcggcat atcaaaccaa tattgaggtg caaaagcttg aggagcaaat ttcatccgaa 1468801 aataagcaaa ttggtgacct cgaaaaaagc gttgctgatt taagcaaacc gcagcgcatt 1468861 atggacattg cgaaaaagaa cggcttgaat ttaaaagata aaaaagtgaa aaacatacag 1468921 gaatgattca aatgccaaaa aagaataaat ttatgaatag aggagcagcg attctaagta 1468981 tttgtttcgc tctctttttc tttgtcatcc tggggagaat ggcatatatt caaataaccg 1469041 gaaaagcgaa cggcgaagtg cttgcgacaa aagcgacaga gcagcatgaa aagaaacgga 1469101 ccatcgaagc gagccgcggc tcgattttag accgaaaagg aaaagtcatt gcagaggaca 1469161 cagcgacgta taaactgatt gcgattctcg ataaaaaaat gaccactgat gtcaagcatc 1469221 ctcagcatgt tgtaaacaaa gaaaaaacgg cggaagcatt gtctaaagtg ataaacttgg 1469281 acaaggccga catccttgat atcttaaata aagatgcaaa acaagtcgag tttggctcag 1469341 ctggccggga tattacgtat tcacaaaagc aaaaaatcga aaaaatgaaa ctcccgggca 1469401 tttcattttt acgggataca aaacgctact atccaaacgg agtatttgca tctaatctaa 1469461 tcggctatgc cgaggttgat gaagaaacaa atgaaatttc cggcgcgatg ggattagaaa 1469521 aagtgctgga taagtatttg aaggagcggg acggatatgt gacatatgaa agcgacaaat 1469581 ccggctggga gctcccgaac agcaaaaata aaattacagc gccaaaaaat ggtgacaatg 1469641 tatatttaac cattgaccag aaaattcaaa cctttttgga agacagcatg acaaaagtgg 1469701 cgcaaaagta taatccgaaa aaaatcatgg ccgcagtcgt tgatccgaaa acgggcaaag 1469761 tccttgccat gggacagcgc ccaagctttg atccgaacaa gcgcgatgtg acaaactact 1469821 ataatgattt gatttcatat gcgtatgaac ccgggtccac gatgaagatc tttacactcg 1469881 ctgctgcgat gcaggaaaac gtgtttaatg cgaacgaaaa atataaatca gggacatttg 1469941 aagttggcgg agcacctgtt aaggatcaca ataacggtgt aggctggggt ccgacaacat 1470001 atcatgacgg cgtcctaagg tcgtcgaatg tcgcttttgc gaaactggcg aaagaaaagc 1470061 tgggatatga ccgcctcaat caatatttgc acaaattcaa tttttaccag aaaacaggta 1470121 ttgatttgcc aggagaagtc tccagcaaaa tcaactttaa atatgaattt gataaggcgt 1470181 caactgcata tggccaagcg tctgcggtca caccaattca gcagattcag gccgcaacgg 1470241 caattgcaaa tgacggtaaa atgatgaaac cttatgtcat tgaccatatc gttgaccctg 1470301 ataaagataa aactatttat caaaataagc cggaatcagc cggaactcca atttctgcaa 1470361 gtactgcgaa aaaggtgcgg gatatattag gagaagtcgt tacatcgaag atcggaacag 1470421 ggcaagctta taaaatcgaa ggttttgatg ttgccgggaa aacaggtact gcgcaaatag 1470481 ccggtaaagg cggatattta gacggcacag ataactatat cttttcgttt atgggtatgg 1470541 cgccaaaaga tgatcctgag cttttaattt atgttgctgt acagcagccg caactaaaag 1470601 caggacaaag cagttcagat ccagtatcag aaatcttcaa tccaacaatg aaaaatagcc 1470661 tgcactacct aaacatcgaa ccaactgaaa aatctgactc agataaggaa gaaacaaaag 1470721 cgcagacaat gcctgattta acagatcaaa cggtagctgc tgctcaaaag aaagcaaaag 1470781 aggagaatct cacaccaatt gtcatcggca gtgatgtcgc tgtaaaagaa cagtatccga 1470841 aagcggatga ggaagttctc accaatcaaa aggtcttcct gaaaacgggc ggcaaaatca 1470901 aaatgcctga tatgacaggc tggtcgagaa gagaggttct gcagtacggc gagctcgcgg 1470961 gaattcatat tgaagtaagc ggacaaggct acgctgtcag ccaaagtgtt aagaaagaca 1471021 aagaaatcaa agacaaaacc gtaatcaagg ttaagtttaa aaatcctgat taaaaagaaa 1471081 gccgtcgtta tgcaggcttt ctttttttat gccttcagag gagcatcgtt ctacctgtcc 1471141 aaattcaggc ataaaatgaa acaagcctaa ataaggagtg aacggtctct tgcgcgtctc 1471201 gaatgtaacg gttagaaaac gtttattatt tgttttgctt tttggcgtga tcgtgtttct 1471261 gatcattgat acaaggctgg ggtatgttca gtttgtgatg ggcgaaaaac tgacttcgct 1471321 agcgaaagat tcctggagcc ggaacttgcc gtttgagccg gagagaggcg agattctgga 1471381 tcggaatggt gtgaagctcg caacaaataa aagtgcgccg accgtattcg tcgtgccgcg 1471441 ccaagttcag aatccgatga aaacgagcaa gcagcttgcg gcggtgctca atatgtcaga 1471501 agaaaaagta tataaacatg tgacaaaaaa agcgtcaatc gaaaagatca ctcctgaagg 1471561 gagaaaaatt tcaaatgaga aggcgaaaga aatcaaagcg cttgatttaa aaggtgtgta 1471621 tgttgcggag gacagtatcc gtcattaccc gttcggcagc tttttatctc atgtgcttgg 1471681 atttgcagga attgacaacc aagggctcct tggacttgaa gcctattacg acgatgattt 1471741 aaaaggggaa aaaggttctg ttaagtttta tacagatgcc aaggggaaga agatgcctga 1471801 tgaagcggat gactatacgc cgcctaagga tgggcttgat atgaagctga cagttgattc 1471861 aaaggttcag acgataatgg aaagagagct tgataacgct gaggccaaat atcatccgga 1471921 cggcatgatt gccgtagcca tgaatccgaa aaacggagaa attttgggga tgtctagcag 1471981 gcctgacttc gaccctgctg attaccaatc tgttgatccg tccgtctaca atcgaaatct 1472041 gccagtatgg agcacgtatg aaccgggatc tacctttaaa attattacac ttgcagcagc 1472101 ccttgaagag caaaaagtaa atttgaaacg ggatcaattt tatgataaag ggcatgctga 1472161 agtggacgga gcgagactgc ggtgctggaa aagaggcggg cacgggctgc agacgtatct 1472221 ggaagttgtg cagaactcct gcaacccggg gtttgttgaa ttaggcgagc gcttaggaaa 1472281 ggaaaagctt ttcaaatata tcaaagactt tggttttgga caaaaaacgg ggattgatct 1472341 ccaaggcgag ggaacaggca tcttattccc gcttgagaga gtgggcccgg tggagcaagc 1472401 aactacggct ttcggacagg gagtatccgt cacgccgatt cagcaggttg cagcagtatc 1472461 cgccgctgta aacggaggaa cgctctatac accttatatt gcaaaggaat ggatcgatcc 1472521 tgttacgaag aaaacggtca aaaaacaatc accaatcgca aagaaacaag tcatttctga 1472581 ggaaacatcc aaacaaatcc gctatgctct agaaagcgtc gtcgcagaag gaaccggccg 1472641 caatgcattt gtagaaggat atcgtgtcgg aggaaaaacg ggaactgcac aaaaggttaa 1472701 agatggaaaa tatcttgaaa acaaccatat tgtatcattt atcggtttcg cgccagcaga 1472761 tgatccgagt ctagtcgtct acgttgcggt ggataacccg aaaggcacga ttcagtttgg 1472821 cggaacggtg gcagcgccta ttgtcggaaa tattatgaga gacagtctgc cggaacttgg 1472881 tgtgaagccc cggaaaaatc aaatcgagaa aaaataccaa tggaacgaca caaaaacaat 1472941 agaagttccg aatgttgtag ggatgtctgt ctcagatctt gagtcactat tggtgaatct 1473001 caatgtggat gcttccggga aagggagcaa aatcgttaaa caatcgccag ctgccggaac 1473061 gaaagtaaaa gaaggctcaa agatacgcgt gtatttgact gaagaagatg aaaaggaggc 1473121 agccgattga ttcgggctgc ctattctttt attgcagaaa aaatgctgat atctttcaag 1473181 attagctgga tgtatccttt tatttacgct aaaatatgaa ctgtatgctt aaaatcatta 1473241 ccacatcatt tgatgtgact tcaatgataa aaagaacgaa ttagaatgtt gagaggtttg 1473301 atacgatgaa acttacaaag ctgcttacat acttaacaac cgaaccttct gtaaacgact 1473361 cacaagaccc tgaaataact tcaattgaga tggactccag ggaagtaaag aaagggagtc 1473421 tttttgtatg tgtaaaaggg tatacggtgg atggccacga ttttgcgcaa aaagcagtag 1473481 aaaacggtgc agcggctatt gtggcagaaa gagaggtcga tgtgaatgtt cctgttatta 1473541 ttgtccggca gtcacttcgc gcgctcagcg ttttgtctga tgcgttttac ggacagccga 1473601 cgaagaagct tcagctgatt gggataacag ggacaaacgg caaaacatca acgacccaca 1473661 tggtcgatga gattctgaaa aaagcgggaa aacgcacagg cttgatcggt acaatgtaca 1473721 tgaaaatcgg agacgaaaca cttcctgtta aaaacacgac tccggaaagc gtcacgctgc 1473781 agaaaacgtt taagaaaatg aatgacaagc acgttgacac tgcaatcatg gaggtttctt 1473841 cccacgcttt gtctttagga cgcgtccatg gctgtgatta tgatattgcc gtgtttacga 1473901 atttaacaca ggaccatctg gactatcata aaacgatgga tgagtaccgg catgcaaaaa 1473961 gcttgctctt ttcccaactt ggcggggctt tcaaccatga acatccaaag cgtgccgtcc 1474021 tgaatgctga cgatgaggcg agcgcttatt ttgaaaaggt aacagctgcg catatctcta 1474081 catacggaat taaaaacgat gctgatgtga tggcgaagaa catcagtatc actgcacagg 1474141 gcacaagctt tgatctcgtg acaaacaaag gcacgaagca catcacgatg tctctcgtcg 1474201 gacaatttaa tgtgtataac gtgctggccg ctgttgcgac atgtattgca gcaggcatac 1474261 cgtttgaaat catcactgag gctgttgaag aattgcatgg tgtaagaggc cgttttgaat 1474321 tggtcaatca gcagcaggag tttcctgtca ttgtagacta cgcgcacaca ccggacagcc 1474381 ttgaaaatgt gctggagaca tgcagagaca tgacggaagg aaagctattt gtcgttgtcg 1474441 gctgcggagg agacagagat aagacgaagc gcccgaaaat ggctaaaatt gctgtggagc 1474501 tggctgacga gccgattttc acgtcagata acccgagaag cgaagatcct cgcgcgattt 1474561 taagagatat ggaagccgga gtagagaacg catactatca cagtattgca aaccgcgagc 1474621 aggcgatctt tttcgcaatt gccaatgcca aaaaaggcga cgttgtcctc attgccggaa 1474681 aaggacatga aacctatcag cagatcggaa atgaaacttt cgattttgat gatgctgaag 1474741 tagcggcgag agccattgtt gaactcaata agaataagac gaattcatag gaaagagatg 1474801 ttactgaata atggagcttg aaaagatttt tcatatggaa aaaaatcatg aatatgataa 1474861 ctacgtatgt cgtttgaaag aaacaggagg agaaaaggac aatgcttgag caagtcattc 1474921 tgtttacaat tttaatgggg tttttaatta gtgttctgct ctctccgatt cttattccgt 1474981 ttttaagaag attaaaattc ggccagagta ttagagaaga aggaccgaaa tcacatcaga 1475041 aaaaatcagg gacaccgaca atgggcgggg tcatgatcat actttctatc atagtgacaa 1475101 caattgttat gacacagaag ttttcagaaa taagccccga aatggtgctg cttctgtttg 1475161 ttacgctagg ctacggtttg cttggctttt tagatgatta catcaaggtt gtcatgaagc 1475221 gcaatcttgg attgacatca aagcaaaagc tgatcggaca aattattatt gcggttgtat 1475281 tttacgccgt gtatcattac tacaattttg cgacggatat tcgcattcct ggaactgact 1475341 tatcatttga tcttggctgg gcttacttta tccttgtgct ctttatgcta gtcggcggat 1475401 caaacgcagt taacctgact gacggccttg acgggttatt atccggtact gcggcgattg 1475461 cctttggcgc ctttgccatt ctggcatgga atcagtctca atatgacgta gcgattttct 1475521 cagttgccgt tgtcggtgca gttctgggct tccttgtatt taatgctcat ccggccaaag 1475581 tttttatggg agatacggga tcgcttgcat tgggaggagc catcgttacc attgccattt 1475641 taacgaaatt agagatcctg ctggttatca tcggcggtgt attcgttatc gagacattat 1475701 ccgttatttt gcaggtcatc agctttaaaa cgacaggtaa acgaatcttt aaaatgagtc 1475761 cgcttcatca ccattatgag cttgtcggct ggtctgaatg gagagtagtc gtgacgtttt 1475821 gggctgcggg acttttgctt gccgttttag gaatttacat cgaggtgtgg ttataagtgg 1475881 aaaatgatca atttttacag aaacagcatt ttttaatcct tgggcttgcg aaaagcggat 1475941 atgcggcggc ctccattctt catgaaaaag gcatttatgt tgcagtcaat gatcaaaagc 1476001 cttttgaaga aaatgaaccg gcacaaaagc tttctgaaaa aggaatcgaa gttgtttgcg 1476061 gagagcatcc agtttctctg ttcgatcagc atcaaatcac gattctgatc aaaaacccgg 1476121 gaattcctta tgaaaatatc atggttcagg aagcagagaa acgaggtatt ccggtttgga 1476181 cggaaattga gctcgcttac tacctgacca gcgccaagtt tatcgggatt accggatcga 1476241 acggtaaaac gaccacgaca acgctaattt acgaaatgct caaggctgac tcgcaaaaag 1476301 cactgattgc cggaaacatc ggcacagtcg caagtgaggt tgcctatcat gctgatggag 1476361 atgaatggat cgttaccgaa ctgtcttcgt ttcagctgat gggaacacac gctttcagac 1476421 cggaaatcag cctgatttta aatgtatttg acgcccatct ggattatcac catacgcgcg 1476481 aaaactatga aaaagcgaaa cagaaagtgt accttcatca gactgcttca gataaagcta 1476541 ttgtcaacca ggatgatgaa accgtcgtgc gtcttgctga agccggaaaa gccgaaatcg 1476601 tcccattttc agtcagcaaa acgcttgaac agggcgcata tgtaaaagac agtatgatta 1476661 tgtttaacgg cgaagccatt cttcctctgg aagaggttgt actgcccggt gctcataacc 1476721 tggagaacat tttagcagct attgcagttg tgaaaacggc aggagcatcc aatgaggcgg 1476781 ttaaaaaggt gctgacaagc tttactggtg tgaagcaccg cctccaatat gtcacaactg 1476841 tgaatggccg caaattttat aacgacagta aagcaacaaa cattctggcg acaagcaagg 1476901 cgctttcagc ttttgataag ccggtcattc tgcttgcggg cggactggat cgcggaaatg 1476961 gttttgatga cttgaaacct tatatgaagc atgtcaaagc agtgcttaca tttggccaga 1477021 cggcgccaaa actcgagaaa ctcggcaatg aactgggaat acaacatgtc aaacgtgtcg 1477081 ataatgttga acaagcagta tctgcggcgt ttgcgctctc aaatgaagga gatgtcatcc 1477141 tgctgtcacc cgcgtgtgcg agctgggatc aattcaaaac atttgaagaa cgcggtgaca 1477201 tgtttataga tgccgtgcat atgcttaagt aagggcttgt cttgaagtaa atcggcagcc 1477261 ctaatgactt taagcttggg gtgtcgattg ctttgactac taaaaaaaca tcgcctgatt 1477321 tgttattggt catcattacg ttattattat taacaatcgg attaattatg gtgtacagtg 1477381 cgagtgcggt atgggcggat tataaatttg acgactcatt ctttttcgcg aaacggcagc 1477441 ttttgtttgc gggaatcggc gtcattgcta tgttttttat catgaatgtt gattattgga 1477501 cttggaggac atggtccaaa ttgctgatgg ttatctgctt tttccttctg gtgcttgttt 1477561 tgataccggg cgtcggaatg gtgcggaacg gttcaagaag ctggatcgga gtcggagcat 1477621 tcagcataca gccttcagag tttatgaagc ttgcgatgat tgcattcctt gctaaatttc 1477681 tctctgaaaa acaaaaaaac atcacatcgt tcagacgggg gttcgtccct gcacttggca 1477741 tcgtgttttc agcatttttg attatcatgt gccagcctga cctcggaacg gggacagtta 1477801 tggtcggaac ttgtattgtc atgatttttg tagccggcgc acggatcgcc catttcgtct 1477861 ttctcgggct gatcggcctc agcggatttg tcgggctcgt actatcggct ccatatcgga 1477921 taaagcggat tacctcatac ttaaatccat gggaagaccc gctcggaagc ggatttcaga 1477981 tcattcaatc gctttatgca gtggggcccg gcgggttgtt cggaatgggg ctcggacaaa 1478041 gcagacagaa gttcttttat ctgcctgagc cgcaaacaga ctttattttc gccatcttgt 1478101 cagaggagct gggctttatc gggggaacac ttattttgct cctcttcagc gtcctgctgt 1478161 ggagaggaat cagaattgcg cttggtgcgc ctgatctgta cggaagcttt gtcgcagtcg 1478221 gcattatttc aatgattgcc attcaagtca tgataaatat cggcgtagtc acgggcctga 1478281 ttcctgtaac aggcatcacg ctcccgtttc tgagctacgg aggctcttca ttgactctaa 1478341 tgctgatggc agttggtgtg ctgctgaatg taagccgcta ctcgaggtat taacgaatgt 1478401 atttccaagc ctcctgtcta acatgaagct tggaaacaat tgatgcgata accctgtcca 1478461 acaaaacagg gttatcgtta tgttatagag aaacttagac tgggggaaaa aagaaatgcg 1478521 aattgcaata agcggaggcg gtacaggggg acatatttat cctgctcttg cttttattaa 1478581 agaagtgcaa agacgtcatc ctaatgtgga atttttatat atcggaacag aaaacgggct 1478641 ggagaaaaaa attgttgagc gggagaatat accgtttcgt tcaattgaaa ttacaggatt 1478701 taaaagaaaa ttgtcatttg aaaatgtcaa gactgtgatg cgttttctga agggcgtcaa 1478761 aaagagtaaa tcgtatttag cggaatttaa gcccgatgcc gtaattggaa cgggcggtta 1478821 tgtatgtggg ccggttgtct atgccgctgc gaaaatggga attccgacta ttgtccacga 1478881 acaaaacagc ctgccgggca tcacgaataa gtttctttca aaatatgtta ataaagtagc 1478941 gatttgtttt gaagaagcga aatcacattt tcctagcgag aaagttgtat ttacgggaaa 1479001 cccgagagcc tctgaagtcg tctcaataaa gacgggacga tcattggctg aatttgggct 1479061 ttctgaagac aaaaaaacgg tcttaatttt cggcggaagc cgaggcgctg caccgattaa 1479121 ccgcgctgtc attgacatgc aggatgtgct gaaaacaaga gactatcaag tgctgtatat 1479181 caccggtgaa gttcactatg aaaaagtaat gaatgagctg aaaagcaagg gtgccgctga 1479241 taatatggtc acaaagccgt ttcttcatca aatgcctgag tatttaaagg ccattgatgt 1479301 cattgtggcc agagccggtg cgacaacgat tgccgaaatt actgctctcg gaatcccaag 1479361 tgttctgatc ccaagtccat atgtgacagc gaatcaccag gaggtcaatg cgaggtctct 1479421 tggccagcat gatgcggcga ttgtactgaa agaaacagag ctcagcgggg agaagctgat 1479481 tgaagcgcta gaccggattg tactgaatga gcaaacgtta aaggaaatga gcgaacgaac 1479541 aaagtcactc ggtgttcctg acgcggctgc ccgtttatac agcgtactcg aggaattaaa 1479601 aaaatagtag aaaagcaaat ggaatgcgga ggtttacgat ggagaaagtg atacaggaat 1479661 taaaagaacg agaagtcggc aaggttcttg caaatgaacc gctcgcgaat catacaacga 1479721 tgaaaatcgg cggacctgcg gatgtattgg tcattccaag cagtgtggat gctgttaaag 1479781 acatcatgga cgtgattaaa aaatatgatg tgaagtggac agtcatcggc cgcggatcaa 1479841 atcttcttgt tttagatgaa ggaattagag gcgtagtgat caagctgggg gcgggtcttg 1479901 accatttgga gcttgaaggg gaacaagtaa cagtcggagg cggttattcg gtggtccgcc 1479961 ttgctacatc attgagcaaa aaaggcctgt ccggtttgga atttgctgcc ggcattccag 1480021 gatcagtcgg cggagcggtt tatatgaatg ccggcgctca cggttctgat atgagcgaga 1480081 tcctcgtcaa agcgcatatt ttatttgaag acggaacgat tgagtggctg acaaatgagc 1480141 agatggattt cagctacagg acatctgtac tgcaaaagaa acgcccgggc gtttgccttg 1480201 aagctgtttt gcagcttgag cagaaggata aggaatcaat cgttcagcaa atgcaaagca 1480261 ataaagacta tagaaaaaat acacagccgt attcaagccc ttgtgcggga agcatattca 1480321 gaaatccgct tccgaatcat gccgggaacc ttgtagaaaa agcaggcttg aaaggatatc 1480381 aaatcggcgg tgcaaagata tcggagatgc acggaaactt catcgtcaat gcggggggag 1480441 catcagcaaa agatgtgctt gatctcattg accatgtgaa aaagacaatc cgtgaaaaat 1480501 acgagattga tatgcacaca gaggttgaaa tcatcggcgg aaatcgctga ttcaagttct 1480561 gactgaagct gttcatatga tatactgtaa gcaaacgaca aacggcatca tagtatgccg 1480621 tttgttttgg aatagacaga cttttaacag ctgtttcatt tgaatgaggt gaacaggcaa 1480681 tgaacccggg tcaagaccga gaaaaaatcg ttaacattga agagcggatc cctaaaatta 1480741 aagagcagag gaaacaaaag gcaaaccgcc gtctcatttc atttattatg ctctttttta 1480801 ttatggtgct gatcattgtg tacctgcaaa caccaatcag taaagtatca acaatctctg 1480861 ttacagggaa tgaaaatgta tcaaaaaagg aaattatcga cctttccgat attaacagcg 1480921 gagatactga gttttggagt ttggacaagc aaaaaacaga aaagaagatt cagcaaaata 1480981 aattagtgaa aaaagcggag atcagcaaat cgcttcctaa taaaatcaac attgcaatcg 1481041 aagaatataa agcgattgct tatttagaaa aagacgatgt gtactatgaa gtgcttgaaa 1481101 acggctcagt tctgccaaac gaagtaacgc cggatgatgc cggaccgatt ttagtgaatt 1481161 ggacaaacgc gaagaagcgg tctcaaatgg ccaagcagct cgatgcgttg tcaaattcgt 1481221 taaaacagtc gatttcagaa atttattata cgcctgtaaa aatggatgaa aaccgtatta 1481281 agttgtacat gaacgacggt tatgttgtta cggcatctat taaaacgttt gcagaccgaa 1481341 tgaagacgta tccttctatc atctcacagc taagcagcaa taaaaaagga atcattcatt 1481401 tagaagttgc cacctatttt gaagagtttg ggaaaaacga taaagctgct aaaaaggaag 1481461 atgaaaattg aggggcaaat cagcagtcct tctttccttg attatgctta tcgcaggttt 1481521 tttgatttca ttttcttttc aaatgacaaa agaaaacaac aaaagcgcgg ctgagacgga 1481581 agagtggaaa aaagaatatg cgctgagaga tgaactgctg aaacaagaga aagaaaataa 1481641 gaagtttgaa aaagaattat atcaaaagca aaacaaagtc cgccaggcgg aaaataagct 1481701 gaagaaagag aagtcggaat actataatgt cctcgaagat acagaaaaat acaggatgta 1481761 tattggggaa gtcggtgtgc agggagaagg cgttgaggtg acattggaag atgcgtcata 1481821 cataccggaa ggggagaatg tgaatagtta catcgttcac gaaagccata tcttccaagt 1481881 agtaaacgaa ctgtatatct caggagcggc agctgtcgcc gttaatggac agcgtttgac 1481941 gcatgattcg tatatcaaat gcaatggtcc tgtggtaacg gtagacgggg tgcagcatcc 1482001 cgctccgttt acggtatccg ctattggaga tccagatgtc ctgctgccct cgttaaatat 1482061 cgctggaggc ctaattgatc agctgtcaat ggatcatatt tctgtgtcgg cagaaaaaga 1482121 gaaaaacgta caaatgaaac cgattctgaa aacgaaggaa tgactgaaaa agcgggtgaa 1482181 atagattgaa aataaagcgt tccttcataa gcatcagtgt tcttatggtc atcttcggcc 1482241 tgatgatatc tgttcagttt aattcgttaa agcaccccaa agtccgggat acaagagata 1482301 tgtgggatat tagggaagag ctgacatcag agcagaagaa gcaggaaaag ctgctggctg 1482361 aaataaacaa atatgacaaa ttgctgaata gctattcgca aacgaaagaa atgacaaaag 1482421 aaaccgcgct aaataatacc ttgcaatcct taaaaaaaac agccggcatg accgatataa 1482481 caggtagcgg aattgtcatt acgatttccc cgcttttttc tgaaagctta acaggagagc 1482541 cgatcgaaaa tccgcctccg gatttgctga aaaagctgat aaatgaactc aactcctacg 1482601 gtgcagagca tatctcgatt aatgagcgaa gagttgtgaa tcatacagtc atcagagata 1482661 taaacggcac tacaaaaata gacggatacg cccttgacga ttatccttta acagtaaaag 1482721 tgcttgccaa agatccggac atgttacaca gcagagtgaa ggggtcaggc cttgaggatc 1482781 tttttgcatc tgaaaattta gcattaaaag ccggtaaatc tgaaagcaaa ctaacattaa 1482841 aagcatatga cagaccactg gacgtacaac agctgaaact gcttaaagac tgaaaaggag 1482901 gagaattgtc atgtggctgc ccgtgttggg actggtgctc ggaatagcga ttggactaat 1482961 gacaaactta acgataccga gtgaatactc aaactattta tcgcttgcgg tgcttgccgc 1483021 acttgataca ttaatcggcg gaatcagggc gcatttacaa ggtacatatg atgaaatggt 1483081 atttgtttcc ggtttctttt ttaatattat attggcaata agtttagctt ttctgggagt 1483141 ccatcttggt gtagacttgt atttagcagg tatattcgca tttggagtca gattatttca 1483201 gaatatagcc gttatcagaa gaaatctact aacaaagtgg actctttcta aaaaaaataa 1483261 aaaaaatgtg atataaaaga ggatatacat aggatataac gaatattttc aataaacata 1483321 aaatgtgaaa agcacataaa aatattctgt tgttattttt tgttacacac ttgtaaagcc 1483381 acattcattg tattgttgtt ccgcaaataa tagaatagaa atgatcgaaa tgtgaggagg 1483441 tgccatagaa tgaacaacaa tgaactttac gtcagtcttg acatcggtac gtccaataca 1483501 aaagtgatcg tcggagaaat gacagatgat tcccttaata ttatcggtgt gggaaatgta 1483561 ccgtctgaag ggttgaaaaa aggctcaatc gttgatatag atgagaccgt tcattctata 1483621 agaaaagcgt ttgaccaagc tgaaagaatg gtaggttttc cgcttagaaa agctattgtc 1483681 ggcgttaatg gaaattatat caatattcaa gatacaaacg gtgttgtagc agtttccagt 1483741 gaaaataaag aaattcaggt tgaagatgta cgccgtgtca tggaggcggc acaggttgtt 1483801 tccgtaccgc atgaacagct gattgttgac gtcattccta aacagtttat cgtagatgga 1483861 agagatgaaa tcaccgaccc gaaaaaaatg ctgggtgtgc gtttagaagt agagggcacc 1483921 ttgatcaccg gttcaaaaac aatcttacat aacttactcc gctgcgttga aagagctggt 1483981 attgaaataa ctgatatttg ccttcagccg ctggcagccg gttctgctgc attatcaaag 1484041 gacgagaaaa accttggtgt ggctctcatt gatatagggg gagggtcaac aaccattgcc 1484101 gtattccaga acggacatct cacttctacc cgtgtcattc ctctcggagg cgaaaatatc 1484161 accaaagata tctccatcgg attgagaacg tcaacagaag aagcagaacg cgtgaaaaag 1484221 caacttggac atgcctacta tgacgaagcc tcggaagatg aaatatttga ggtaaccgtt 1484281 ataggcacca atcaaaaaca aacatttaca cagcaagaag cagcgaatat cattgaagcg 1484341 agagtagagg aaattcttga aattgtttca gaagagcttc gcagtatggg aattaccgat 1484401 ctgccgggag gcttcgtgct gacaggagga caagcagcta tgccgggtgt catgtctttg 1484461 gcacaggatg tgctgcaaaa caatgtcaga gtggcaagcc cgaattatat cggtgtaaga 1484521 gatcctcaat atatgacggg agtgggcctg atccaattcg cctgccggaa tgcaagaatc 1484581 caaggcagaa aaataggctt taagatgcct gaagaagcga tacaggaaat cgcagtctca 1484641 tcatctgagg aacaagagca gcatcatcac caaaatgagg tgcagcagcg gccaaaagga 1484701 aaacaaaaaa cacaagccga acataataaa cagagcaaaa tgaaaaaact attaagcatg 1484761 ttttgggaat agatagatag tcattcggca gattaggagg atttagcatg ttggagttcg 1484821 aaacaaacat agacggctta gcatcaatta aagtaatcgg agtaggaggc ggcggtaaca 1484881 acgccgttaa ccgaatgatt gaaaatgaag tgcaaggagt agagtatatc gcggtaaaca 1484941 cggacgctca agctcttaac ctgtcaaaag cagaagtgaa aatgcaaatc ggcgcaaagc 1485001 tgactagagg attgggagca ggtgcgaatc cggaagtcgg gaaaaaagcc gctgaagaaa 1485061 gcaaagagca gattgaagaa gcacttaaag gtgctgacat ggtattcgtg acagctggta 1485121 tgggcggcgg aacaggaaca ggtgccgcac cggttatcgc acaaatcgcg aaagacttag 1485181 gcgcattaac agtcggcgtt gtgacaagac cgtttacctt cgaaggacgc aaaagacagc 1485241 ttcaggctgc aggcggaatc tcggcaatga aagaagcggt ggatacactg atcgtgatcc 1485301 cgaacgaccg tatccttgaa attgttgata aaaacacacc gatgcttgaa gcattccgcg 1485361 aagcggataa cgtacttcgc caaggggttc aaggtatttc tgacttgatt gctacacctg 1485421 gtcttatcaa ccttgacttt gctgatgtga aaacaatcat gtcaaacaaa ggatctgctt 1485481 tgatgggtat cggtattgct actggggaaa atcgcgcggc agaggcagca aaaaaagcaa 1485541 tttccagccc gcttcttgaa gcggccattg acggtgcgca aggcgtcctc atgaacatca 1485601 ctggaggaac aaacctcagc ctatatgagg ttcaggaagc agcagacatt gtcgcttcgg 1485661 cgtctgatca agacgtaaac atgattttcg gttctgttat taatgaaaat ctaaaagatg 1485721 agattgtggt gacagtgatt gcaaccggct ttatcgaaca agagaaggac gtgacgaagc 1485781 ctcagcgtcc aagcttaaat caaagcatca aaacacacaa tcaaagtgtt ccgaagcgtg 1485841 agccaaaacg tgaggaacct cagcagcaga acacagtaag ccgtcatact tcacagccgg 1485901 ctgatgatac gcttgacatc ccgacattct taagaaaccg taataaacgc ggctaatgta 1485961 aaggacaaaa tcgttttcga ttttgtcctt ttttgttttt ctcttcacac tttccttctt 1486021 ataaagtctt tttccctatt gcttccttcg cgagctcgat tatggatggt ttacgttttg 1486081 gaaaaagtaa ggtatcctag ttcgtacaaa gttttatgaa aattaaaaca attataaaag 1486141 gcaataaaga ggaggaccac gatgattttg cagcttgaca atgtctcact aaaacggaat 1486201 gggaaatgga tactgaaaga tattcattgg aaggtggaag aaaaggaaaa ttgggtgctt 1486261 tacggcctaa atggcgccgg gaagacagcg ctgttaaata tgctttgctc atattatttt 1486321 ccaacatcag gcgagatgca ggtgctcggc catgaatttg gcaaaacaga gcttggggaa 1486381 aagctcagac gtaaaattgg cctcgtctca gcagctcttc agcaaaaatt gtatccggca 1486441 gattcagctt ttgaaattgc tttgagcgga gcttacgctt cgattgggtt atatgaaacg 1486501 ccaagtaagg aaaccaggga aaaagcgata ggtttgttag aggacttggg agcaattgaa 1486561 tatgccgatc gccgctatga aaccctttct caaggggaaa aacaaagagc attgattgct 1486621 agagcactaa tggccgatcc ggagctgctg atactggatg aaccagtcac aggactggat 1486681 tttattgccc gggaaaagct gttagatacg attacataca ttgcaaacaa agaaaatgca 1486741 ccatctatcc tttatgtgac tcatcatgct gaagaaattt tgcctgtctt tgataaagcc 1486801 cttttattaa aacagggaga ggtttttgga tccggagaaa taaaggaaat gcttactgat 1486861 caaatacttt ccgctttttt tgatacgcca atccatgtat tatggaatca ggatcggccg 1486921 tttttaacaa gagctgagcc gataacgaat gcctgacaaa tatatataga ttcatcctag 1486981 gggtgctttg cgaagctgag agagactttg tctcaaccct tttgacctga tctggatcat 1487041 gccagcggag ggaagcggtg aaaagcggag tacatcggac tccgtttgtt tttattaagc 1487101 cgtttcatca catttgaaac ggcttttttg attttaaaga ataggagcgg atttacattg 1487161 gatcaacaaa tatactcttt gcaaaaaaaa gtggaagaac ataaggagga gcttattcag 1487221 cttgcgaaaa cgctgatttc ttatcaaaca cctgctccgc ctgcaagaaa tacagagggc 1487281 attcagtctt ggattgcggg atatttaaat gaattgggat tctcgatcga caaatgggat 1487341 gtgtaccctg gagatcccaa tgttgtaggg aagctaaaag gaacagattc agcagattat 1487401 tatagcctga ttatcaatgg ccatgtagat gtggcagagg taaaagagga tgaagaatgg 1487461 aagcacgatc cgtttcatcc cattgaaaaa aacggtctct taatcgggcg aggcgcttcc 1487521 gatatgaagg gcggaatggc ttgtgtgctg tttgctgtca aattaattcg tgaagcaagc 1487581 attgaacttc caggtgatct gattctgcaa tcggttattg gggaggaagt tggagaggcc 1487641 ggcacacttg aatgctgcaa gaggggctac cacgctgatt ttgcaattgt cgcggatacg 1487701 agcgatatgc atattcaagg ccaaggcggt gtcattacag gctggatcga aatcaaaagc 1487761 agtcaaacat ttcatgatgg aacgagacgg aatatgattc atgcaggcgg aggaacattc 1487821 ggagcaagcg caattgaaaa aatggcaaaa atcattgcgg ggctcggtga acttgagcgc 1487881 cactggtcta ttatgaaaag ttatcccggt tttaaaccag gcacaaatac gattaacccg 1487941 gcagttatag aaggcggcag acatgcggct tttatagcgg acgaatgccg gctgtggatc 1488001 acagtccatt tttatccgaa tgaaacccat gaccaagtgg cagcggaaat agaagattac 1488061 gtcaatcggc tgagtgacag tgatatttgg cttagggaaa accgccctgt attcaagtgg 1488121 ggaggctcat ctatgataga agacagggga gaaatttttc cggcattgga agttgaccct 1488181 ggccacccag gcgtcttagc gctaactgcc tctcatcaga aagtgaaacg ggagtgtcca 1488241 attattgacg tttctcaatc agttacagat ggcggatggc tgtatgatgc cggtattcca 1488301 tgcgtaatat acggtcctgg agatctgcac aatgcacact ctgtgaacga gaaggtatcg 1488361 attgagcagc tagtagagta tacaaaaatt atactcgatt ttatcatcag ctggtgcagc 1488421 cggaaaaaag aacaatgaca tgaaaatttc ttcttgctga caaggttcag cctgcccgtt 1488481 catatacttg aacaaaagga cggaaaaagg acgtgatgga atgatcagca tttcagaatt 1488541 tcaggtaaag gatgtcgtca atgtctcaaa cggaaaaaag ctggggagta ttggtgatat 1488601 tgatatcaat gtgaccactg gaaaaattca ggcgatcata ctcggaggaa atgggaaagt 1488661 tctcggattt tttggaaaag aagaggaatt ggtcattcca tggcgaaata tagtaaaaat 1488721 cggggaagat gtaatcttag tccgattaag tgaaccacat gcataaacct gcttgtctgc 1488781 cgcagattgg caaatgccgg aagtctcgat tcttccggca catttcattt agaaatatgc 1488841 aaatcggcgc tcaacgaatg cagtaagatg tggtaaaata agtgggaaat tccgcttttt 1488901 taaatgtttg tcgaaaggtt ggatcatcat gaatacatat cacccattca gtcttaccac 1488961 accctcgaca ctcatgatac aagactgggc tcaaacgaat caaaacaaca aagaggtcat 1489021 tgccggattt acgacaaaaa acggcggtgt cagccaaaag ccttttgaat cgttaaatac 1489081 aggattgcac gttcatgaca aagatgcaga tgtagttaaa aatcgtgaat atattgccga 1489141 tatgtttaat actgatttgc agtcttgggt attcgctgat cagacacatg ataatcgcgt 1489201 tcagaaagtg acgcagaggg ataggggaaa aggcgcccgt gagtatcaca cggctctaaa 1489261 agcaacggac gggatctata caaatgaaaa aaatgtattt ttagcattat gctttgctga 1489321 ttgtgtgcct cttttctttt atgatccggt taagtcgctt gtcggagtcg cccatgccgg 1489381 gtggaaaggc accgtcaaac agattggcag agaaatggtg aagcaatgga ctgagaagga 1489441 aggttcaaat ccctcagata tttacgctgt tattggcccg tctatcagcg gagcatgcta 1489501 tacggtagac gaccgcgtca tggatgctgt ccgcgcattg ccggtttcag cagaccttgc 1489561 cgccaatcag acggcaaagg cacaatatca gcttgatctg aaagagctga accgtcttat 1489621 actgatggac agcggtttgg caagtgaaca aatttctgtc agcggtttat gcacggaaag 1489681 cgagccgtct cttttctatt ctcatcgccg cgatcagggg aaaactggac ggatgatgtc 1489741 ctttatcgga atgaaggagg cataaaagat cttgcgtgtt gttgataatt tacgacatat 1489801 aaacgaacga ataaacgaag catgtaacag atcgggccgc agctccgatg aagttacggt 1489861 tattgcagtc acaaaatatg tatcacctga aagagcacag gaggcagtag atgctggcat 1489921 cacctgcctc ggagagaatc gggatgcgga actgctccgc aaacaggaat tgatgaaagg 1489981 gaatccggaa tggcatttta tcggcagtct gcaatcaaga aaagcaaaat ctgtcgtcaa 1490041 ttcggtttcc tatatccatt ccctagaccg gctctcatta gcgaaagaaa ttgaaaaacg 1490101 ggctgaaggt actgtacgat gctttgtgca ggtcaatacc tctcttgagc cttctaaaca 1490161 tggcatgaaa aaagaagaag tcattccatt catacaggag ctttccggtt tcgaacatat 1490221 ccttgttgcc gggctgatga caatggctcc gctgactgat gatcaagatc agatcagaag 1490281 ctgtttcagg tcgctgagag aactccgtga ccaggttcag aagctgaacc agccgaacgc 1490341 tccgtgtact gaactgtcga tgggcatgtc aaatgatttt gaaattgcaa ttgaagaagg 1490401 agctacttat attagaatcg gctcatcgtt agtcggaaat gaaacagggg gtgtacagca 1490461 atgagtatga aaaataaact gaaaaacttt ttctcaatgg aagatgaaga atacgaatat 1490521 gaatatattg agacagagcg ggaatctcat gaggagcatg agcaaaaaga aaagccggct 1490581 tacaacggga ataaacctgc gggcaaacag aatgtagtga gcttgcaaag tgttcagaaa 1490641 tcctctaaag tggtgttgag tgagccgcgc gtttatgcgg aggcgcagga aatagccgac 1490701 catttgaaga accggcgggc agttgtcgtc aatcttcagc ggatacagca tgaccaggcg 1490761 aagcggattg ttgacttttt aagcggaacc gtttatgcca ttggcggcga tattcaaaga 1490821 atcggctcag atattttcct ctgcacgcct gacaacgtag atgtatcagg cacaatttct 1490881 gagctcatat ctgaagacga acatcagagg tggtaaagcg agatgatcct ttatcaagtt 1490941 ttttcggttt taagcttatt aatcacaata tactcatttg ccctgatcat atatattttt 1491001 atgtcatggg tgccgagtac gagggaaaca gcagtcgggc gttttttggc ttcgatttgt 1491061 gaaccatatc tcgaaccatt cagaaaaatc atccctccga ttgcaatgct ggatatttca 1491121 ccaatcgtag caatacttgt gcttcggttt gcgacaaccg gcttgtgggg actttatcgc 1491181 atgattgcgt tttaatgtga cagtttgata ggggcttggc agcagccaag cctctttaca 1491241 tagaagggaa agacgatgag cgatatatat cagcacttca gaaaagacga gcgggccttt 1491301 attgatcaag cgctcgaatg gaaaagaatt gtccaggagc agtaccggat gaagctgacc 1491361 gactttttag atccccgaga gcaggtcatc ctctctgctg ttacgggaca ggcagatgtc 1491421 gggcttgcct tttccggcgg ctatgacaga gcggagcgga aacgggcgat tctgtttcca 1491481 gagtacatta ctccggaaga atcagatttt gaactgcagg cgtttaacgt ccgttatgct 1491541 gacaagtttg tctcagtaga tcatcgttct ctgcttggtg cattaatggg cataggatta 1491601 aagcggcaaa aattcggtga catcgtgttt tctgagacag cagtgcaatt gattgtctca 1491661 gccgataccg ctgattttgt ggctgcacag ctgacccaag caggcaaagc ggcggtcagc 1491721 ctagagaaaa tcgacttgtc agaccttaac attccagcag ttgatgtcga aataagagat 1491781 gacacggttt cttctttaag gcttgacgcc gtctgcgcct ctatgagcag gcaatcccgc 1491841 cagaaatcac agacgcttgt gaaaaacggc cttgtgaaag tgaactggaa ggtggttgaa 1491901 gatccttcat acatagtcgc ggaaggggac atgctgtcta tcagaggttt tggccggtgc 1491961 agcttaacaa aaatcgaagg aaaaaccaaa aaagacaaat ggagagttac gtttgaacga 1492021 caaaaatagt cggtttttca gtttttttct ccatctgtgc gaaatttgtt ttataatgtg 1492081 aactagataa ccgtactgaa atgtaaaaat ggaggtggca tcatgccatt aacgccaaat 1492141 gatattcaca acaagacgtt tacaaaaagt tttcgcggat atgatgaaga tgaagtaaat 1492201 gaattcctag cccaagtcag aaaagattac gaaattgttc tccgcaagaa aactgagctt 1492261 gaagcgaaag tcaatgagct tgatgaaaga atcggacact ttgccaatat tgaggagaca 1492321 ttgaataaat caattttagt tgctcaagaa gcggctgaag acgtaaaacg caattctcaa 1492381 aaagaagcaa agctgatcgt tcgggaagcg gagaaaaacg ctgatcgcat tatcaacgaa 1492441 tcgttatcaa aatcaagaaa aattgcaatg gaaattgaag agctgaaaaa acagtctaaa 1492501 gtgttcagaa cacgtttcca aatgctgatt gaagctcagc ttgatcttct gaaaaatgac 1492561 gattgggatc atctccttga gtatgaagtc gacgctgtat ttgaggaaaa ggaataaatt 1492621 ctctgattat cttgacattt tcttagcttg tcgaatataa tacgttcata aattcagatg 1492681 aaaaaacggt tgaaagggac agtcatgttt ccttcaggcc ttcatagcga cccggagatg 1492741 gtgagagtcc gggatggccg gaatcatgta gatcagccct ttagtttcct tgctgaactc 1492801 acagtaggtt aggacgttca tcacgttacg atgctcaaga ggaaaaagtg tatgcttgct 1492861 ttttctaaaa gggtggtacc gcgagataag ctttctcgtc ccttatggga tgagagggct 1492921 ttttttattt tctgaaaaaa tgcagtggag gaatgaaaat ggattttaaa gacacgctct 1492981 taatgccgaa aacagatttc ccgatgcgtg gaaatttgcc aaaccgtgag cctgacattc 1493041 aaaaaaaatg ggaggaagaa gatatctacc gtcttgttca ggaacggacg aaagaccgcc 1493101 cgaaatttgt tttacatgac ggacctccgt atgcaaacgg cgacatccat atgggccatg 1493161 cacttaacaa gattttgaaa gacttcattg tccgctataa atcaatgagc ggctacaacg 1493221 caccgtatgt gccgggctgg gatacacacg gattgccaat tgaaacagct ctgacaaaaa 1493281 acaaaaaggt caaccgcaaa gaaatgtcag tagcggaatt ccgcaaacta tgcgaagagt 1493341 acgcttggaa gcaaatcgag ggacagcgtg agcaattcaa acgtcttggt gtccgcggtg 1493401 actgggaaaa cccatatgtg acattaaaac cggaatacga agcgcagcaa atccgcgtat 1493461 ttggtgaaat ggcaaaacga ggctacattt acaaaggcct taaaccggtt aactggtcac 1493521 cttcaagtga gtctgctctg gctgaagccg agatcgaata tcaagataaa cgttcagcat 1493581 ctatttacgt cgcttttggt gtaaaagacg gaaaaggcgt tcttgaaaac ggcgagcgca 1493641 tcatcatttg gacaacaacg ccgtggacaa ttccggcgaa cctcggaatc tcagtgcacc 1493701 ctgatcttga gtacagcgtg attgcagtag gtgaagaccg ctttgttgta gcaagtgcct 1493761 tagtcgaaaa tgttgcatcg gcatgcggat ttgatcagta tgaagtgaca agaacggtca 1493821 aagggaaaga ccttgagaac attatcgctg aacacccgct atatggcaga gactctctcg 1493881 ttatgcttgg tgaacacgta acaactgatg ccggaacagg ctgtgttcat acagcgcctg 1493941 gacatgggga agatgacttt atcatcggcc aaaaatacgg tttagatgtg ctttgcccgg 1494001 tcgatgaaaa aggtgtaatg acaagcgaag ctcctggctt tgaaggcatg ttctatgatg 1494061 atgcaaacaa agcgatcaca cagcagcttg atgaaaaagg cgcacttgtg aagcttgaat 1494121 tcattactca ttcttatccg catgattgga gaacaaaaaa accaaccatt ttcagagcaa 1494181 cagcgcaatg gtttgcgtct attaaagatt tcagatcaga cctgctggat gccattaaag 1494241 aaaccaaatg ggttcctgaa tggggcgagc agcgtttgca caacatggtt cgggaccgcg 1494301 gagactggtg tatttccaga cagcgtgcgt ggggtgtgcc gattccggta ttttacgctg 1494361 aaaacggaga accggttatt acagatgaaa ccattgaaca tgtttctgaa ttgttcagac 1494421 agcatggatc aaacatttgg tttgaaaaag aagcaaagga tcttcttccg gaaggcttta 1494481 cgcatcctgg cagcccgaac ggcacattta caaaagaaca ggatatcatg gatgtttggt 1494541 ttgattcagg ctcttcacat caagcagtgc ttgaagaacg tgatgacctc gttcgcccgg 1494601 ctgatctata cctagaggga tctgaccaat atcgcggctg gtttaactct tctctttcta 1494661 cagcagtagc cgtaacaggg aaagcgccgt ataaaggtgt gctcagccat gggttcgcac 1494721 tggatggaga aggacgtaag atgagtaaat caatcggtaa cgttgttgtt ccggctaaag 1494781 tcatgaaaca gcttggtgcc gacatcttaa gattatgggt atcttcagtg gattatcagg 1494841 cggacgttcg cgtgtctgac gccattctga agcaggttgc ggaagtatat cgtaaaatcc 1494901 gcaacacgtt ccgtttcctt cacggcaacc ttttcgattt tgatccaaaa acaaatgcgg 1494961 tggctgtcga agatcttcgc gaagtggatc agtatatgct gattaagctg aacaagctga 1495021 ttgataaagt gaaaaaagcg tatgatgagt acgaatttgc ggttgtgtat cacagcattc 1495081 ataatttctg cacaatcgaa ttgagctcat tctaccttga ttttgcaaaa gatattgtct 1495141 acatcgagca tgcggatcat ccggatagac gcagcatgca gacagtattc tacgaaacgc 1495201 ttcttgcatt agtgaagctt tcagcgccta tccttccaca tacggcagac gaattgtggt 1495261 ctcatttaac atttgttgaa gagcagagcg ttcagttgac cgatatgccg gaaacaatca 1495321 cggttccaaa cagtgaagcg actgaagaaa aatttgaccg ctttatggct cttcgtgatg 1495381 acgtgttaaa agcattagaa actgcgcgaa atgaaaaaat tatcggtaaa tctttggaag 1495441 caaacctgaa attgtatcca aacaaagaaa acaaggagct cttggcttcc ataaaagaaa 1495501 acctttctca gctgtttatt gtgtctgaac tgacaatcag cgaagaaaat gaagcgccga 1495561 acgatgcgca aagctttgcg acgggtaaaa tcgctgtcga gaaagcggaa ggcgaaatgt 1495621 gtgagagatc tcgtgtgatt tcaaaagatg taggggcaaa tccgaaatat cctacacttt 1495681 cattacgcaa cgctgaaatc gttgaaaaat actatcaaaa ataatgcaaa agagcccggc 1495741 gtaaaagccg ggcttttttt gtgccaagag tgacatcctt tagaacgaaa ggaaaaatct 1495801 tatgggcttt agatcatcat tcacaggcaa caataaagat actacgttaa gagcaggagt 1495861 tgtgaagaat gaatgatcaa ctgaccgcaa tttatacgga acttcttctg atgaaagaag 1495921 aattacagtc gagattattt gagtattctt gctttcaggt ttctacaagc ccgcaagcag 1495981 caatcaatca aaaacaaaaa gcaactctga tctatcatat taaagaagaa cttcaagacg 1496041 ttctccttgc attgtccaaa atcgaaaacg gcacattcgg atactgtgaa gaaactgggg 1496101 cccccattcc tcttgcaaag ctggcagtgc tgccgacggc ccgaacagca aacgattttc 1496161 tttattctgt ccaatttgag aaaaaaacgc ttccgatatg gaaatcaacg gatatcgaat 1496221 atggtcaggc actgtatgaa taacagtgtc tgtccggtta atatgcctga tatttcttta 1496281 ctccagtgct ttttattgat aaaatgcata atggattaaa gtaaccgtaa actggaggaa 1496341 cgtttgtgct gtattatatg attgcactac ttattattgc agccgatcaa ttgacaaaat 1496401 ggctagttgt taagaacatg gaacttggcc aaagcattcc gatcattgat caggtattct 1496461 atatcacctc ccatcgcaat acgggtgctg catgggggat attagcgggt caaatgtggt 1496521 ttttctacct cataacaacc gctgttatta ttggtattgt ttattacata cagcgttata 1496581 caaagggaca aaggcttctt ggcgttgccc tcggacttat gcttggcggt gccatcggca 1496641 actttatcga tcgggctgtc agacaggaag ttgtggattt tatccatgtt attattgtca 1496701 attacaatta cccgatattt aacatcgcgg actcttcact atgtgtcggc gtaatgcttt 1496761 tatttataca aatgctgttg gacagcggga aaaagaaaaa ggagcaatag catgaatcaa 1496821 attgatataa ccgcttcaga agaacaaaaa agtgagcgga ttgataaatt tttggcatcg 1496881 actgagaatg attggtcaag aacccaggtt cagcaatggg taaaagacgg acaggttgtc 1496941 gtgaacggaa gcgcggtgaa agcgaattat aaaattcagc cgggtgatca ggtgaccgtc 1497001 actgtacctg aaccggaagc gctcgacgtc ctggcagagc ctatggatct ggatatttat 1497061 tatgaggacc aggatgtgct ggtcgtcaac aaacctcgcg gaatggttgt tcacccagca 1497121 cccgggcatc ttacgggcac acttgtaaac ggtcttatgg ctcattgcac agacctttcc 1497181 ggaataaatg gtgtgatgcg cccgggtatt gttcacagaa tcgataagga cacgtccggt 1497241 ttattaatgg tggcgaaaaa tgatatggcg cacgagtcac tcgtaaacca attggtcaac 1497301 aaaacggtca cgcggaaata tacggcggtt gtccacgggc ttatttctca tgatgacggc 1497361 acaattgacg cgccgatcgg acgggataaa aaagaccgtc aaagcatgac tgtgacacgt 1497421 gatggcaaaa acgctgtcac tcattttcat gtgcttgagc gttttcagga ttttacgtta 1497481 gtggagtgcc agcttgaaac agggagaacc catcaaattc gtgttcatat gaaatatatc 1497541 ggattcccat tagcaggcga tccgaaatac ggcccaagaa aaacaatcga ctttaatggc 1497601 caagcgcttc acgcgggagt tttaggtttt gaccatccac gaacaggaga atatgtcgaa 1497661 tttgaagcgc cgcttcccga ggatatggca gaattaatcg aaaacctcag aaaaaacggt 1497721 tgacagaggg tttcttttct gaaataataa acgaagctga atagattctt taaaacagtc 1497781 cagagaggct gagaaggata acggatagac gggatgcgtg tataggcgcg caccttgtcc 1497841 taaaacccct ctatgctctg gcaggagggg ttttttcttc tatatgaact gtgaggtgtc 1497901 acacattgaa tcaaaaagct gtcattctcg acgaacaggc aattagacgg gcgctgacca 1497961 ggattgctca cgaaatgatc gaacgcaata aaggaatgaa taactgcatt cttgtcggca 1498021 ttaagacaag agggatttac ctggcaaaac gccttgcgga acgcattgaa cagattgagg 1498081 gaaatcctgt tacagtcggt gaaattgata ttactcttta cagagatgat ctttctaaaa 1498141 aaacaagcaa cgatgaaccg cttgtaaaag gtgcagatat tccggtagat attacagatc 1498201 aaaaagtcat tctcgttgat gatgttctgt ataccggaag aacagtcaga gcaggaatgg 1498261 atgcgcttgt tgatgtaggc agaccttcct ccattcagct tgcagtgctt gtggacagag 1498321 gacaccggga gctgccgatc cgagcggatt atatcgggaa aaacatcccg acatcaaagt 1498381 ctgaaaaggt tatggtacag cttgatgagg tagaccaaaa cgatctcgtc gccatttatg 1498441 aaaacgaata atagatcacc tttttaaggg caatccagag aggttgcaaa gaggtgcaca 1498501 acaaaggccc aaaaagtatt cggcaggtct ttgtatgcct ctttgcgtaa aaaagcaaag 1498561 aggttttttt atacagtcat tgagtcatcc taaaatgaaa gtcaacaatc agggggaaat 1498621 catcatgagt aagaaaaaag taaatttagg ggtcagggat gtcccgacac ctttctcttg 1498681 ggtttcattc agccttcagc atttgtttgc catgtttggc tcaaccattt tggttccgaa 1498741 gctcgtcgga atgagtcctg ctgtggcgtt ggtgacaagc ggcatcggaa cactggcgta 1498801 ccttcttatt accaaaggac aaattccggc gtatctcggt tcatccttcg cctttatttc 1498861 tccgatcatt ctggtaaaag cgaccggcgg gccgggagcg gcaatggttg gagcgtttct 1498921 tgcagggctg gtgtacgggc tgattgcctt attgattagg cagcttggaa caggatggct 1498981 gatgaagatt ctcccgcctg tagtcgtagg gcctgttatt atcgtcatcg ggctgggact 1499041 ggcaagcact gcagtaaaca tggcgatgta tgctgatccg aacgcgagtg agttggtcta 1499101 cagcttaaag cactttagtg tcgcaggagt tacgctggca attacgatta tttgtgcgat 1499161 tttcttacga gggtttttaa gcctgattcc ggttctgatc ggaatcatcg gcggatacct 1499221 gtttgccctt actcaaggga ttgtcaactt ccagccggtg cttgacgcga aatggtttgc 1499281 agtgcctgaa tttatcattc cgttcaaaga ttattcaccg tcagttacgc tcggcatcgc 1499341 agccgcaatg gttcctgtcg catttgtcac aatgtcagag catatcggcc accaaatggt 1499401 gctgagcaag gttgtcggac aagacttcat taaaaagcca ggtcttcatc gctctattat 1499461 gggtgacagt gtggcgacaa tcctcgcttc cctgatcggc ggccctccga caacgactta 1499521 cggagaaaac attggcgtgc tggccatcac aagagtattc agcgtctttg tcatcggggg 1499581 cgcggcagtg attgcccttt gcttcggctt tatcggcaaa atttcagcgc tgatcagttc 1499641 agtgccgtca gcggtcatgg gaggcgtctc cttcctgctg ttcggaatca ttgcttcaag 1499701 cggcctgaga atgctgattg acaacaaaat tgattatgaa aacaacagaa acctcattat 1499761 tacatcagtt atccttgtca tcggtgtagg aggcgctttt atccaagtgt ctcagggcgg 1499821 attccaagtg tcaggaatgg cgcttgccgc aattgtcggt gtcatcttaa acctgattct 1499881 tccgcaggcg aaggaagagc aggcagacac atctgaacaa catcatattt aaaacctttt 1499941 aatgaaagtc cagagaggct tggaagggtt atgaagagaa ggaagcttca atgctgccct 1500001 ctatttaacc ataccccgag tctatcttag accggggttt tttttcagcc ttaagttgaa 1500061 aagagagggg aaagaacatg aagcatttaa cgacgatgag tgaacttagc actgaggaaa 1500121 tcaaagattt gcttcaaaca gcacaagagc tcaaaagcgg aaaaacagac aatcagctta 1500181 caggaaagtt tgcagcaaac ctgtttttcg aaccgagcac gagaacgcgg ttcagctttg 1500241 aggtcgcaga aaaaaagctg ggcatgaatg tgcttaacct tgatggaaca agcacaagcg 1500301 tgcaaaaagg cgaaacctta tatgacacga tccggacgct tgaatcaatc ggtgtggacg 1500361 tctgcgtcat caggcacagt gaggatgagt attatgaaga gcttgtcagc caggtgaaca 1500421 ttccgattct gaatgcggga gacgggtgcg gccagcatcc aacacaatca ctgcttgatt 1500481 taatgacgat ttatgaagag ttcaatacgt ttaaagggct taccgtctcc attcacggcg 1500541 acatcaagca tagcagagtg gcaaggtcaa atgcggaagt gttgacaaga ttgggtgccc 1500601 gggtcctatt ttccggccct tcggaatggc aggatgaaga aaatacattc ggcacgtatg 1500661 tctcaatgga tgaagcagtt gagtcttccg atgttgtcat gctgctgcgc attcaaaatg 1500721 aacgacatca gtccgctgtc agtcaggaag gctatttaaa caaatacggc ttgaccgtag 1500781 aacgggctga gcgtatgaag cggcatgcga tcatcatgca tcctgctccg gtaaacagag 1500841 gagtggagat tgatgacagc ttagtagaaa gcgaaaaatc aagaatcttc aagcaaatga 1500901 aaaatggcgt atttatcaga atggcagtga tacagcgtgc cttacaaacc aatgtgaaaa 1500961 gaggagaagc agcgtatgtc atatctcatt aaaaacggct ggatactaaa cgaaaatggt 1501021 gaaaaaacac aagcggatat ccgagtgact ggagaaacca tcaccgcaat cggcaagctt 1501081 gatgcaacgg ataatgaaac ggtaattgat gcaaaaggtt tgctcgtttc acctgggttt 1501141 gttgatctcc acgtgcattt cagagagccg ggcggagaga aaaaagaaac tattgaaacc 1501201 ggggcaaaag cagcggcgcg cggcggctat actacagtag cagcaatgcc gaatacgcgg 1501261 ccggttcctg atacaaagga gcagatggaa tgggtgcaaa acagaattaa agaaacatca 1501321 tgcgtaagag ttcttccata tgcatccatt acgatcagac aaatcggcga tgaaatgaca 1501381 aactttgaag cgttaaaaga agccggggca tttgctttta cagatgacgg cgttggtata 1501441 cagacagcag gaatgatgta tgaagcgatg aaacgggcag ccgcaattga caaagcgatt 1501501 gttgcacatt gcgaggacaa ctccttaatt tacggaggga gcgtacatga ggggacattc 1501561 tccaaagcga acgggctaaa cggcattcct tctgtgtgtg aatcggttca tattgctcgc 1501621 gatgtgctgc tggctgaggc ggcaaactgc cattatcatg tatgccatat cagcacaaaa 1501681 gaatctgtca gagttgtacg cgatgcgaaa aaagcgggaa tcagagtgac agcagaagta 1501741 tcgccgcatc atttgctgct ttgtgatgag gacatcccgg ggctggacac aaactataaa 1501801 atgaatcctc cgctccgcag cccagaagac agagctgctt taattgaagg tcttttagac 1501861 ggaacaattg attttatcgc aacagaccat gcaccgcata cggaagaaga gaagaacaca 1501921 gaaatgaagc tggcgccatt cggaattgtc ggcttagaaa cagcattccc gcttctttac 1501981 acacactttg tcaaaaatgg cagctggtca ctgaagcagc tgattgacta catgacaatc 1502041 aagccatgcg aagcgttcgg tctcccatat ggaacattac aaacggggca agctgcggac 1502101 attacgttaa tcgatttaga aaaagaagca gttatagaca aagagacatt tttatcaaaa 1502161 ggaaaaaata caccattcaa cggcatcagt tgcaccggct ggccggtcgc tacaattgcg 1502221 gcagggaagc ttgcttatga agaggggaga cttgtcaaat gaagagacga ttagtactgg 1502281 aaaacggagc ggtattcgag ggagaagctt tcggaagctt agaacacaac atgggagaag 1502341 tcgtttttaa tactgggatg acaggctatc aggaaatttt atctgatcct tcttactgcg 1502401 gacagatcgt aacattaaca tacccgctta tcggaaatta cggcattaac cgtgatgatt 1502461 ttgaatccat tacccctttt gtcaaagggc tgatcatcaa agaattatgt gagctgcctt 1502521 ccaactggcg ttcagcatac accttagacg agtatttaaa aatgaaaaac attcccggac 1502581 tccagggaat tgatacaagg aagctgacaa gaatgatccg cacggcaggc gcgctaaaag 1502641 gaacattcgc ttcatctgat gaagatatcg aagcagtgct gaaaagactg aacgaaacgg 1502701 aattgccaag aaatcaagta tcccaagtat cagcaaaaac agcatatccg agcccgggaa 1502761 gaggcaaacg cattgtcttg gttgacttcg gcatgaaaca cgggattcta agagagctga 1502821 acaaacggaa atgtgacgtc atcgttgtgc cttacaacat tacagcggaa gaggtgcttc 1502881 agctgaaacc ggacggtatc atgctttcta acggacctgg agacccgaag gatgtgcctg 1502941 aagcgattga aatgattaaa ggtgttcttg gaaaagtgcc attattcgga atatgtctcg 1503001 gccaccaatt attcgcgctg gcgtgcgggg cgaatactga aaaaatgaaa ttcggccaca 1503061 ggggctcaaa ccacccggta aaagagctgg ctacaggaaa agttgcctta acatctcaaa 1503121 accatggata tacagtttcg tctatcagta aaacagaact ggaagtgacg catatcgcaa 1503181 ttaacgacga tacgattgaa gggctgaagc ataaaacatt gccggcattt acggttcaat 1503241 atcatcccga agcctcacct ggtcctgagg atgccaacca tctatttgac agattcatcg 1503301 aaatgatcga aacaacagag aaagaagggg aagcggtatg ccaaaacgcg tagacattaa 1503361 caaaatttta gtaatcggat ctggaccgat catcatcggc caagcagcag aatttgacta 1503421 tgcgggaaca caagcctgtc ttgctttgaa agaagaaggc tatgaagtca tccttgtcaa 1503481 ctcaaaccct gcaacgatca tgacagatac agaaatggct gaccgggttt acatcgaacc 1503541 gctcacacct gaattcctga cacgaatcat cagaaaagag cgcccggatg ccattcttcc 1503601 tacactcgga ggccaaaccg gtttgaatct tgcggttgag ctttctgaaa gaggcgtttt 1503661 ggcagaatgc ggcgtcgaag tgcttggcac gaaactgtct gcgattcagc aagctgaaga 1503721 ccgtgacttg ttcagaacat taatgaatga actgaatgaa ccggtgcctg aaagtgagat 1503781 tatccactcc cttgaagaag cagaaaaatt cgtcagtcaa attggattcc ctgtcattgt 1503841 ccgcccggca tatacattag gcggaacagg cggaggcatc tgctcgaatg aaacagagct 1503901 aaaagaaatc gttgagaacg gcttgaaatt aagcccggta caccaatgtc tgcttgaaaa 1503961 aagcatcgcc ggctataaag aaatcgagta tgaagtcatg agagacagcc aggatcacgc 1504021 cattgtcgtt tgtaacatgg aaaacattga tccagttgga atccatactg gagacagtat 1504081 tgttgtcgcg ccgagccaaa cgctcagcga tcgcgaatat cagctcttgc ggaatgtatc 1504141 gttaaaactg attcgcgcgc ttgggatcga aggcggatgt aatgtccagc tcgccttaga 1504201 tccagacagc ttccaatatt acattattga agtaaatccg cgtgtcagcc gttcatctgc 1504261 ccttgcatca aaagcaacgg ggtacccgat tgcaaagctc gctgctaaaa ttgcagtcgg 1504321 actttcatta gatgaaatga tgaacccggt gacaggaaaa acatatgcag catttgaacc 1504381 tgctcttgac tatgtcgtat ccaaaattcc gcgctggccg tttgataagt ttgaatcagc 1504441 aaacagaaag cttggcacgc aaatgaaagc gacaggtgag gtcatggcaa tcggccgcac 1504501 gcttgaagag tcattgctga aggcagtgcg atcactggaa gcggatgtgt atcatcttga 1504561 attgaaggac gccgctgaca tttcagatga gcttcttgaa aagcgaatta aaaaggccgg 1504621 tgatgaacgc ttattctact tagctgaagc gtacagaaga ggctacacgg tagaagacct 1504681 ccatgaattt tccgctatcg atgtcttctt cttgcataag ctgttcggaa tcgtacagtt 1504741 tgaaaaagaa ttgaaggcca atgcgggcga tacagatgtg ctgagacggg caaaagaact 1504801 cggcttctct gatcagtaca tcagccgtga atggaaaatg aaagaatctg agctttacag 1504861 cttgagaaaa caagcgggga ttgcgccggt attcaaaatg gtagatacat gcgcggcgga 1504921 atttgagtca gaaacgccat acttctatag cacatatgaa gaagaaaatg aatctgtcgt 1504981 tacagataag aaaagtgtga tggtgcttgg ttcgggtccg attcgaatcg gtcagggtgt 1505041 cgagttcgac tatgcgacgg ttcactctgt atgggcaatt aaacaagcag gctatgaagc 1505101 cattattgtc aacaacaacc cggaaaccgt ttcaacagac ttcagcatct cagacaagct 1505161 gtattttgaa ccgcttacga ttgaagatgt catgcacatc attgacctcg aacagccaat 1505221 gggcgttgtc gtacaatttg gcggacaaac tgcgattaac cttgctgacg agctttctgc 1505281 acgcggagtg aaaatccttg gaacttcatt agaagattta gaccgtgccg aagaccggga 1505341 taaatttgaa caagcgcttg gagaacttgg tgttcctcag ccgcttggca aaacagcgac 1505401 atcagttaat caggcggtaa gcatcgcaag tgatatcggt tatccggtac tggtacgccc 1505461 ttcctatgta cttggcggcc gggcgatgga gattgtttac catgaagagg aactgcttca 1505521 ttacatgaaa aatgcagtca aaatcaatcc acagcaccct gtattaattg atagatactt 1505581 gaccggaaaa gaaattgaag tcgatgcagt atccgacggt gaaacagtcg tcattccggg 1505641 aattatggag cacattgaac gtgcgggcgt tcactccgga gactcaatcg ctgtttatcc 1505701 gcctcagtct ctcacagagg acattaagaa aaaaattgaa caatacacga tcgcattggc 1505761 taaagggctg aatattgtcg gtttgctcaa tattcaattc gtcttgtcgc aaggcgaggt 1505821 gtacgtgcta gaagtgaatc cgagatcaag cagaaccgta ccgtttttaa gcaaaattac 1505881 gggtatccca atggcgaatc tcgcaacaaa aatcattctt ggtcaaaagc tggctgcgtt 1505941 tggctataca gagggccttc agcctgaaca gcaaggtgta tttgtaaaag cgccggtctt 1506001 ctcctttgcc aagctgagaa gagtggatat tacgttaggg cctgaaatga aatcaacagg 1506061 tgaagtcatg gggaaagatt cgacacttga aaaggcgctc tacaaagcct tgatcgcttc 1506121 aggtattcaa atcccgaact acggttccgt gcttttaaca gtagctgata aggacaaaga 1506181 agaagggctt gccattgcta agcggttcca cgcgatcggc tacaacattt tagcgacgga 1506241 aggaacggca ggctacctga aagaagcttc cattccagcg aaggtcgtcg gaaaaatcgg 1506301 tcaggatggc ccgaacttgc ttgatgtcat cagaaacgga gaagcgcagt ttgtcatcaa 1506361 tacgctgaca aaaggaaagc agccggcaag agacggtttt agaatcagac gtgaatcagt 1506421 agaaaatggt gttgcctgcc taacatcttt agatacggca gaggcgatat tgcgagtgct 1506481 ggaaagcatg acattccgtg ctgatcaaat gccggcagtc aacacaaatc aggaggcggc 1506541 agtcactata tgaaaaaagc gtatttgaca gtatgttcta accagcaaat tgcagaccgg 1506601 gtgtttcaaa tggttctgaa aggggagctt gtccaagggt ttacaacccc tggacagttc 1506661 cttcatctta aagtgagcga agcggttacg cctcttttga gaaggccgat cagcatcgca 1506721 gacgtcaact ttgaaaaaaa tgaagtcacc atcatttatc gggtagatgg ggaagggaca 1506781 agactcttgt cactgaagca gcagggagaa cttgtggatg tcctcgggcc tttgggaaat 1506841 ggctttcctg ttaatgaagt tcaacccgga aagacggctt tgctggtagg aggcggagta 1506901 ggtgtgccgc ctctccaaga gctgtcgaaa cgcttgattg aaaaaggggt aaatgtcatc 1506961 cacgttttag gattccaatc ggcaaaggat gttttttacg aggaagaatg ccggcagtac 1507021 ggagacacgt atgtggcaac agctgacgga agctacgggg aaaccggatt tgtcacagat 1507081 gtgattaaac ggaaaaagct agagtttgat atcctcctca gctgcgggcc gacaccgatg 1507141 ctcaaggcgt taaaacagga atatgcccat aaagaagtat atctgtccat ggaggaacga 1507201 atgggctgcg gaatcggcgc atgcttcgcg tgtgtgtgcc atacaaacga aagtgagaca 1507261 tcctatgtaa aagtatgtct cgacgggcct gtatttaaag ctcaggaggt ggcgctgtaa 1507321 tgctagaggt gaaattgccg ggacttgatt tgaaaaaccc aatcattcct gcatcaggct 1507381 gcttcggttt tggaaaagaa ttttcacgtt tttatgattt gtcttgtctt ggagctatca 1507441 tgattaaggc tacgacaaag gagccgcgct ttgggaatcc gacgccgcgg gtagctgaga 1507501 ctggtgctgg aatgctcaat gcgatcggtc tccaaaatcc ggggctggat agtgtgttgc 1507561 atcatgagct gccgtggctt gagcagtttg atacaccgat cattgccaat gtcgcaggtt 1507621 ctcaagtcga tgattatgtt gaagtcgcag aacatatcag caaagcgcct aatgttcatg 1507681 ctcttgaatt gaatatttcc tgcccgaatg tgaaaacagg cggaatcgct tttggcacga 1507741 atcctgaaat ggctgccgat ttgacaaaag cggtgaaaga ggtttcggat gtacccgttt 1507801 atgtgaagct atccccgaac gtggctaata tcacagaaat tgcattagcg atcgaggaag 1507861 cgggagcgga cggtcttacg atgatcaaca cactaatcgg catgagactc gatttaaaaa 1507921 ccggcaaacc gatattagcg aataaaacag ggggactttc gggccctgct gtgaagccgg 1507981 ttgccattcg catggtgtat gaagtcagcc agatggtcaa catcccgatt atcggaatgg 1508041 gaggcgtgca aacggctgaa gatgccctgg aatttcttct cgcgggagca agcgcagtcg 1508101 ctgtcggaac agcaaacttt gtgaatcctt ttgcatgtcc agagattatt gaacagctcc 1508161 catctgtttt gctccaatac ggctatcaat caattgaaga atgcatcgga aggagctgga 1508221 atcatgaaaa acaacctgcc catcatcgcg cttgattttg cgtcagctga agaaacactt 1508281 gcgttcttag cgccttttca gcaagaaccg ttatttgtaa aggttgggat ggagcttttt 1508341 tatcaagaag ggccatctat cgtgaaacaa ctaaaagaaa gaaactgcga gctattttta 1508401 gatctaaagc ttcatgacat cccgactact gtaaacaaag cgatgaagcg ccttgccagt 1508461 cttggagtag acctcgtcaa tgttcatgct gccgggggca aaaaaatgat gcaggcagct 1508521 ctcgaaggct tagaagaagg tacgccggct ggaaaaaaac gtccgtcact tatcgcggta 1508581 acccagctga caagcacatc tgaacaaatc atgaaagatg aactgctgat cgaaaagtct 1508641 ctgattgata cggttgtgca ctacagcaaa caggcggaag aaagcggact ggatggagtg 1508701 gtctgctctg ttcatgaagc aaaagccatt taccaagcgg tgtcgccttc atttctgact 1508761 gtcactccgg ggatcagaat gtcagaggac gctgcgaatg accaagttcg cgtagcgacg 1508821 cctgccattg caagagagaa aggttcatca gcgattgtag taggacgctc gattacaaaa 1508881 gcggaagacc cggtaaaagc ctataaggct gtcagacttg aatgggaggg aatcaaatct 1508941 tgaaacaaat catcgcaaaa catctattag acatccaagc tgtattttta cgcccgaacg 1509001 agccgttcac atgggcaagc ggcattttat caccgatcta ctgtgacaac cgccttacgc 1509061 tatctttccc agaggtcaga aacgatgttg cttcaggtat cagcaagctt gttaaagagc 1509121 attttcctga agctgaaatg attgcgggaa cagcaactgc cggtattcct catgctgctc 1509181 ttgcggcgga ccatttgaat cttccgatgt gttatgtgag gagcaagccg aaggcgcacg 1509241 gaaaaggcaa tcagattgag ggagctgtgc aagaagggca aaaaacagtc gtcattgaag 1509301 acttaatttc cacaggaggc agcgtgcttg aagcttgtgc agctttacaa gcggccggct 1509361 gtgaagtgct tggtgtcgtc tcaatcttta cgtacggact tcctaaagcg gaggaagcct 1509421 tcgcaaaggc agaactgcca tactactcat taaccgatta tgatacgctc acagaggtcg 1509481 cgcttgaaaa cggaaatatt cattcagatg atctaaaaaa gctgcaaaca tggaaacgaa 1509541 atcccgagtc aaaagattgg tttaaaaaat aaaaaataaa ttcaaatgat gtaaagaggc 1509601 ttcaaagcct tgctgtactt gaaaacaggc tgtgaggcct gtttttttat taatcctata 1509661 aaaaaagtcg ggttgactta tgttagaatt gtgctaaaat ttactacaaa tctaaaaact 1509721 tatcaagagc ggctgaggga ctggacctat gaagcccggc aacctgcata gtttgtaagg 1509781 tgctacttcc agcaaaatga attccatttt gaaagataag ggctgcatgc tgttcctgtc 1509841 tttctttccg ccggattgaa agttttttat tttaagaggt aaaaaggcta tctgtatatc 1509901 agcagccgcg aatcacatta catgggaaaa gacaaccggc agaaagctac tgtttgtttg 1509961 tctccgaaag gaggaaagaa gaaatgttaa cgtatgataa ttgggaagaa ccaacgatta 1510021 catttccgga agacgatcct tataaaggag cgctgtcagt tttaaaatgg gcatacggcc 1510081 attacggcga tcagcttgtt tatgcctgca gtttcggaat tgagggaatc gttctgattg 1510141 acttaattta taaagtgaaa aaagacgcag agattgtgtt tcttgataca ggacttcatt 1510201 ttaaagaaac ctatgaaaca attgaacgag tgaaagagcg ttatccgggt cttaatatca 1510261 tcctgaaaaa accagatctc acccttgagg aacaagccga agaacatggt gacaaactat 1510321 gggaaagaga gccgaatcag tgctgctatc ttagaaaggt cgttccttta agagaggcgc 1510381 tttcaggaca tccagcctgg ctttccggcc tgcgccgtga tcaagggcca agccgtgcca 1510441 atacgaattt cttaaacaaa gatgaaaaat tcaagtcagt aaaagtttgc ccgcttatcc 1510501 attggacttg gaaagacatt tggagatata catcccggaa tgaactggac tacaatccgc 1510561 ttcatgacca aggctatcca agtattggct gtgcgccttg cacttctccc gcttttacag 1510621 cagaagattt gcgctcaggc agatggaatg gtatggcgaa aacagaatgc ggactgcatg 1510681 aataaggagc tgcaaaatgg aattagccgc tattttattt agcttgtttt tcgcgatgaa 1510741 tattggtgca agcggcgctg cagcttcgat gggggttgct tacggctccg gagccatcaa 1510801 aaagaaaact tacgctttga tcctatgcgc agtcggtgtc tttgccgggg cggtcattgg 1510861 cggaggcgag gttgtaaaaa caatcagctc cggcattatt cctgagcaga cgattacact 1510921 gacgattgtt tgcatcatta ttggagctgc tgccctgtcg ctctttactg ctaatctgct 1510981 cggcattcct ttgtcgacaa gtgaagtaac agtcggcgcg gttgtcggcg tgggagtggc 1511041 ttataaagta ttgtttgtga acaatcttct gatcattgtg tcattttggg tttttgtccc 1511101 gctgttcgct ttcggcttca cctatttcgt atctaagctg tttcgttatt ttaagattga 1511161 agtaaaatct tctaaaaagc aaaaaatcct cggcattgtt ttgttagttg ccggattttt 1511221 cgaagcattc tctgccggca tgaataacgt ggcgaatgct gttggcccgt tagtagctgc 1511281 cggtgtgctt gatgtcggaa aaggaacctt gtatggagga gcttttgttg ctcttggcgc 1511341 actgttatta ggccggcgag tgctagaaac aaacgggaag aaaattacga ggttctccaa 1511401 aggggaaggc attctcttat ccggtacagg agcgggactg gtgatcatca gttctgtatt 1511461 tgggatgccg gtgcccttgg cgcaagtcac gtcatcgtct attatcggaa taggcatggc 1511521 gaaaaacggt ccgaacgtgt tccataaaca agttgttcaa acgatgctga aggtatggat 1511581 cgtatcgccg tttttatctt tatcgatttc ttatctgctt gtatccttgt ttttaaaagc 1511641 agattattat tcgatcttta tcatggtaag tgtgctttta gcggcgggcg gtgccatcag 1511701 cctgacaaag gccattcgta aagagagacg ctcagtccac gaacaaggcg ggggaatctg 1511761 atcattaatc tgagtaattt tataagttaa ctaggaggag atggatatta tgagcttagc 1511821 accacacgga ggaacattag taaacagagt agatgaatca tatgatgtga gcggcattca 1511881 aaaagaaatt gaacttgatt taatttcttt cgcggatttg gaattgatcg gtatcggtgc 1511941 atacagcccg attgaaggtt tctttaatga aaaagattac gtatcagtgg tcgaaaacat 1512001 gcgtctttct tccggcgttg tctggtctct tccaatcacg cttccggtcg atgcgcaaaa 1512061 agcagcggaa ctgtcacttg gtgaaacggt aaagttaacg tatgaaggag aaacttacgg 1512121 cgttatccaa atcgaagacc tgtacgtgcc tgacaaacaa aaagaagctg tcaatgtgta 1512181 caaaacagat gaacaggagc atcctggtgt taaaaagctg ttcagccgcg gcaatacata 1512241 tgtcggcgga ccgattacgt tgattaaaaa agcttcaaaa cagttccctg aatttacatt 1512301 tgaaccgtca gaaacgagac gccagtttgc ggaaaaaggc tgggaaacca ttgtcggttt 1512361 ccaaacaaga aaccctgttc acagagcgca tgaatacatt caaaaaacgg ctcttgaaac 1512421 agtagacggc ttgttcttga atccgttagt aggtgaaaca aaatctgatg acattccagc 1512481 tgatgtacgg atggaaagct accaagtgct tcttgatcat tattacccga aagatcgtgt 1512541 tttccttggt gtctttttag cggcgatgcg ttatgcaggc ccgagagaag caattttcca 1512601 cgcgcttgtc agaaagaact acggctgcac acatttcatc gtcggccgtg atcatgcagg 1512661 tgtaggcgac tattacggaa catacgaagc acaggaactg tttgacacat ttaaacctga 1512721 agaactcgga attacaccgc tgaaatttga gcacagcttc ttctgtaaaa aatgcggaaa 1512781 tatgggaaca gcaaaaactt gccctcatgg cagagagcat cacgtcattt tatcaggcac 1512841 taaggtaaga ggtatgctga gagacggtgt gctgccgcct gctgaattca gtcgaaaaga 1512901 agtagtagaa gtgttaatca aagggatgaa gaaaaaagaa gaagtaggcg tatcttaagg 1512961 aggactggca gtgacaaatc gcgatattgt atggcatgaa gcctctatca caaaagaaga 1513021 gtatcagcaa aaaaacaagc ataaaagctc cattctctgg ctgacagggt taagcggctc 1513081 aggcaaatca accattgcca acgccgctgc gagagaattg tttgagcaag gctaccaagt 1513141 cattgtgctg gacggggata atatccgtca cggcctaaat agggatcttg gtttttctga 1513201 tgaagaccga aaagaaaaca tccgccggat cggagaggtg gcgaagcttt ttgttcagca 1513261 gggaaccatt gtgattactg cttttatctc tcctttccgc gaggacagac aacaggttcg 1513321 cgagcttgtg gaagcgggcg aatttaatga agtctacatt aaatgcgacc ttgatatttg 1513381 tgaacaaaga gatccgaaag ggctttacaa aaaagcaaga aacggcgaga ttccgttctt 1513441 tacaggaatt gattctcctt atgaagaacc ggaagctcca gagctcgttc ttgattcagg 1513501 acagcatgac cgtgaagcgt gtaaaaatca gctgatcgag tttgttaaac aaaaattgag 1513561 ctgaatatga tctgctgcgt tcttctcaga tgccggaatg caagcgagaa catcatcaca 1513621 gcgaatcttc tggaagaact cgaatagatc gggggaaata cgatggggaa agtatatatt 1513681 gtaggagcgg gtcccggtga ccctgatctg ctgacaatta aagcgctgaa agccattgaa 1513741 aaagctgatg tcatcttata tgacagatta gtaaataaag agattttaca atatgccaaa 1513801 gagcaagcag acctgatcta ctgcgggaag cttccggatt ttcatacgat gaagcaggaa 1513861 accatcaatc gatttcttgt gaagtatgcg caaaaaggga aaatggttgt cagactgaaa 1513921 ggcggagacc cttttgtgtt cgggagagga ggggaagaag cggaatgcct ctctgaaaat 1513981 ggaattccgt ttgaaatcat tcccggcatt acgtctggaa tcgcggcagc cgcttatgcc 1514041 gggattcctg ttacccatcg ggatgcgggc tctaacgtcg cttttgtaac gggtcactat 1514101 aaaaaagaag aagattttga ggaaaagtgg aaagcgctgg ctacaggaat tgatacactt 1514161 gtcatctata tgggtatcaa aaacgtgcag cagattgaaa gaaaactcct tgaaaatggc 1514221 cgggacggtt ctacgccagc agcctttatt cattggggga caacggacaa gcaaaaatct 1514281 gttttttgta cagttgacac cctttcagaa acggtgataa aagaaaacat tacaaatccg 1514341 agtttaattg tcattggaaa tgttgtaaat tatcactata agctggaatg gtttgaatct 1514401 gaactaaaaa aacaagattt aagcgaggcg ttgtaaaaat gaaacaagca attttatatg 1514461 tcggccacgg cagccgggtc aaaaaagcgc agcaagaagc cgcagccttt ttggaaggat 1514521 gcaaggccca catctctgtg ccagtacaag aaatcagctt tttagagctt caggagccga 1514581 caattgagac aggatttgaa gcatgtgtga agcaaggtgc cactcatatc gcagtggtgc 1514641 ctctgcttct tttaacagct gcgcatgcaa aacatgatat tccggaagaa attgtccgtg 1514701 ttgcatctcg atatccatca gtccgtattt catacggaaa gccgatcggg attgacgaag 1514761 aagtagtcaa ggctgtatat caccgaatga aagacatagg tgttccgtat gaaaatgcca 1514821 gagtggtgct catcggaagg ggaagttcag atccagacgt caaaagagac gtaaccggaa 1514881 ttgctaatct tcttcaggaa atggttccag tgaaggaagt cattccgtgc tttttgacag 1514941 catgcggccc taattacaaa gaggtttttt cagaacttga aaaagatgac ggcataacaa 1515001 cctttatcgt tccatatttg ctttttacgg gtatgctgat gaatgaaatc gaacgagagg 1515061 ttcagaaatt aaaagcccat aatccgaacg tctacctctc ttcctatatc ggttttcatc 1515121 ctcatgtgaa aaacgcattt ttgaaccgtg tgagagaaac tgcggcaaat tctgagggac 1515181 aatttgattt tgatggaggt tcatatgctt ccgctgcaca ttagcctgga aaagaagaag 1515241 gttgtgattg cggggggcgg aagcatcgct ctcagaaggc tgaaaacggt gatttctgag 1515301 ggagctgata taacgcttgt cagtccggat gtggaaccgg aaatcaagca aatggcagaa 1515361 gagcggcgta tcaaatggga aaaacggaca attgaaaaag aagattatct caatgctttc 1515421 ttcattattg ctgcgacgga taatgcggca gtgaacaaag aaattgccca atccgcttcg 1515481 ccttttcagc ttgtcaattg tgtcagtgac gctgagcttg gcaatgtata tatgccgaaa 1515541 atcgtaaaaa gagggcatgt cactgtgtct gtttctacaa gcggagccag tccaaagcac 1515601 acgaaagagc ttgctgaaaa cgtggataag ctgattgacg gcgattttgt tgctgaagtg 1515661 aacaggcttt atcagatgag aagaaagaaa taagccagag catacaaatg ctctggcttt 1515721 tctttatgcg gctcagcttt ttttgagctt gatgacagta tcagcatcag gcgtgacaaa 1515781 gacggtatgc tggctgtcat aagtgacgaa accgggtttc gcgccgtttg gttttttgac 1515841 atgcctgatt tttgtataat ctacaggcac tgaacttgaa tctttagctt ttgaaaaata 1515901 agctgcaatt gtcgcggctt ccatgattgt ttgctcatca ggttcgctgc ttctgatcac 1515961 aacgtgggag ccgggaatgt ccttcgtgtg aagccagata tcgtctctgg ccgccactct 1516021 tgtcgttaaa tattcatttt gacgattgtt cttacccact aaaattgtca gccctgaggt 1516081 ggattcatat gtttctaaca ccggattgtg cggtttttgc tttttctggc ctttttgctg 1516141 cttagggcgt aaatatttgc cctcaacaag ctcttccctg atttcgctga tatcccgggg 1516201 agaagcggac gaaagctgct gaatcagctg atcaaaatat tcgatctctt cctgtgccag 1516261 cctgatttgc tcctcgacaa ctgcgaccga atttttcgct ttctgatact tcgtgaaata 1516321 ggcctgtgcg ttttcagaag gcgttttgtt cgggtttaaa ggaatcgtga ttgtcgggct 1516381 ttcttcatca taataattga tgacctcagc ctgtttatca ccttttttca gcatatataa 1516441 attagcggtt aaaagctctc cgtaaagctg aaattccttc gcgttttccg aatactccag 1516501 ggttttctct aattttttga ttttgttggc attcttcttc cgttcgttca caacaaaacg 1516561 ctcaagatcc tgagcctgtt gcttaacccg gtctcgttca gcttttccga aataaaaacg 1516621 gtcgagcagt tcgcttaatg aatcaaaacg gcgcgcttcg ccctttagat gagtcagctc 1516681 cagcagataa aaatattcct ttccgtttac agtcgtaatg ttgggaatga aacggtgctc 1516741 tttcacttcg gcaaacagtg ccagcaacgc ttttggcagt gtgactttgt tggcaaggcc 1516801 tgctctgtga accgcttctt tggcgaaaag cggagacacg cctgaaaagt ggtcgacaat 1516861 ttgtttatca agccttcctt cttgaaagct gaggtgacgc aaaatatcat cttctgacgc 1516921 ctcaagaggc gatattttgt cctgagcagg cggaagctta taatcttggc cgggcagtac 1516981 tgtacggtag ctgttcattg acggtgataa atgcttaagt ccgtcgataa tcacattttc 1517041 tgctgcgtca gtcaaaatga tattgctgtg gcggcccata atttctacat aaagctttcg 1517101 tacggtttca tcgccaattt cgtttcggct tttgatatga aaaatcataa tgcggtctaa 1517161 gcccgcttgt tcaattttct caatgaatcc gccttcgata tgctttctca gcaacatgca 1517221 aaacattggc ggttcgcttg gattttcata agcttgtgcc gtgatatgca cccgtgaata 1517281 gctcggatgt gccgataata atagtttttg gttttttccc ttggcacgga tgtggaaaat 1517341 cacatcgtgc ttatatggct gatggatttt tgtaattcgt ccgcccatta ttttctcgtt 1517401 aagttcgtgt gtcattccgt atgtaaacat gccatcaaac gacatatgca atacaccctc 1517461 tcattcttcc tgcattcgat aattatagca tgaaatggga cgagtcagaa taagcatgct 1517521 tatagagtga tatctctata agagagcagg ggagtggacg agcggaatga agtttcatga 1517581 aatgggacaa acagatttac tagaggcaac caatacgtcc atgaaacaag gattaacaga 1517641 aaaagaggta aaaaaacgcc ttgacaagca tggaccaaac gagctgcaag aagggaaaaa 1517701 aacttcagcg cttctcttgt ttttcgcgca gttcaaagat tttatggtgc ttgtgcttct 1517761 ggcggcaacg ttaatctcag gatttcttgg tgaatatgta gatgcggttg cgattattgc 1517821 gattgtgttt gtgaatggca tactcggttt ctttcaagaa aggcgtgctg agcaatctct 1517881 tcaggcttta aaagagcttt caacaccgca cgtcatggca ctcagggaag gaagctggac 1517941 aaagattcct tctaaggaac tggtgccggg tgatattgtg aaatttacga gcggggacag 1518001 aattggcgca gacgttcgaa ttgttgaagc gagaagcctt gaaatagaag aatcagcgct 1518061 aaccggggaa tcaatcccgg ttgtgaagca tgctgataaa ttgaaaaaac cggatgtttc 1518121 actcggcgat attaccaata tggcatttat gggtacgatt gtgacccgcg gcagcggtgt 1518181 cggggttgtc gtcgggacag gaatgaatac ggctatgggg aaaattgccg acatgcttga 1518241 atcggcaggg acattgtcaa ccccgctgca aagaagactg gagcagctcg ggaagatttt 1518301 gattgttgtt gcattgcttc tgaccgtact tgtcgttgct gtcggtgtta ttcagggtca 1518361 tgatctgtac agtatgtttt tagcaggtgt ctcgttagcg gtagccgcta ttccggaggg 1518421 gctgccggcg attgtgacag tggcgctttc gcttggtgta cagaggatga ttaaacaaaa 1518481 atccattgtt agaaagcttc ctgctgttga aacgcttggg tgtgcgtcta tcatttgctc 1518541 agataaaaca gggacaatga cccaaaacaa aatgacagtg acgcatgtct ggtccggagg 1518601 gaaaacatgg agagtggcag gggccggcta tgaaccgaaa ggaagcttca cactaaacga 1518661 aaaagagatc agtgtcaatg aacataagcc gcttcagcag atgcttctgt tcggagcgct 1518721 ttgtaacaac tccaatattg agaaaagaga cggcgaatat gtgcttgacg gagatccgac 1518781 agagggagcg ctgctcaccg cggcaagaaa aggcggtttt tcaaaggagt ttgttgaatc 1518841 taattacaga gtgattgaag aatttccgtt tgattccgca cggaaaatga tgactgtcat 1518901 cgtagagaat caagacagaa agcgctatat cattacaaaa ggtgcgccgg atgtactcat 1518961 gcagcgatct tcccgtattt attatgatgg ctcagcggct cttttttcaa atgaaagaaa 1519021 agcagaaaca gaggcggtat taagacattt ggcatcacag gcgctcagaa cgatagcggt 1519081 cgcctacagg ccgataaaag caggcgaaac accgtcaatg gagcaggcgg aaaaagatct 1519141 gaccatgctt ggcctttcag gtatcattga tcccccgcgg ccggaagtca gacaggcgat 1519201 taaagaatgc cgtgaagcgg gaattaagac cgtcatgatt acaggtgatc atgtagaaac 1519261 cgctaaagcg atagcgaaag acttgcgcct ccttccgaaa agcggcaaaa tcatggacgg 1519321 caagatgctg aatgaacttt ctcaagaaga gctttctcat gtggtggagg atgtgtatgt 1519381 atttgcccgc gtttcccctg aacataaact aaaaatcgta aaagcctatc aggagaacgg 1519441 gcatattgtg gcgatgacgg gagacggcgt caatgatgct cctgccatta aacaggctga 1519501 tatcggcgtc tctatgggca ttaccgggac agatgtggcc aaagaagcat catctcttgt 1519561 tctcgtggat gataattttg cgacgattaa atcagcgata aaagaaggca ggaacatcta 1519621 cgaaaatatc aggaagttta tcagatacct gttggcgtct aacgtcggag aaatccttgt 1519681 catgctgttt gcgatgctgc ttgcccttcc tttaccgctg gttccgattc agattttgtg 1519741 ggtcaacttg gtgacggacg gattgccggc aatggcgctc ggcatggatc agccggaagg 1519801 agacgtcatg aagcgcaagc cccgtcatcc gaaagaaggg gtatttgccc gcaagctagg 1519861 atggaaggtc gtttccagag gatttttaat cggagttgcc actattttag cgtttatcat 1519921 tgtgtaccac cgcaatccgg aaaacttggc ttatgcccag acgatcgcgt ttgccacatt 1519981 ggtgctcgct cagcttattc acgtgtttga ctgccgcagc gaaacttctg ttttctctag 1520041 aaatccgttt caaaacctgt atttaatcgg cgcggtattg tcatccattt tgctgatgct 1520101 tgtagtaatc tactatccgc cgcttcagcc gattttccat actgtagcca tcacgccggg 1520161 ggactggatg ctcgtcatcg gtatgtccgc catccctact tttttgctgg cggggtcact 1520221 tttaacaaga aaaaaataaa ttcatatgat ataatcttag gggtaatagc gtgtctattg 1520281 cccttttatt atgagaacag ggaagaattg ggtgttttaa aatgatacga agtatgacag 1520341 gcttcggcag tgcaagcaaa acacaagacg atctctctgt aagcgttgaa cttaaatctg 1520401 tgaactacag atttaaagaa gtgaacgctc gtttgccaag gcctttgcta tattttgaag 1520461 ataagctgaa acagaccatt ctgcagcata ttcagcgcgg aagaattgag cttttcgtat 1520521 ccgttgacag cgatatgctt gttgagaaaa ggcttgaaat tgattggccg ctgctcgatg 1520581 agtttgtcgc agccgcgaga gatatgaaga agcggtatca attgtctgca gagcccgatg 1520641 taatggattt ctttaagctt gatcatgtcg tccaggttca tgaagaacag acgcaaaatg 1520701 acaagctgga ggcgttgatc atcgatgctg cagaagaagc ggtaaaaggt ctctgtgaaa 1520761 tgcgtgaaaa agaggggctg ctcttagcga aagactgcct gatgcatatt gatcagcttg 1520821 aagagctggt gagagaaact gaattgctgg ctgcagatgt cgtatctcgt taccgggaac 1520881 ggctgtatgc cagaatcaaa gaatggactg aagacgtatt agacgagagc cggcttgtaa 1520941 cagaatgcgc tatttttgca gaccgctctg atatcactga agagattaca aggctgaaga 1521001 gccacttcgc ccagtttcgt gatatattag ctagtggcgg agctgtcggg cgcaaactcg 1521061 actttcttgt tcaggagctc aatcgggaag caaatacgat cggctcaaaa gcaaatgatc 1521121 atcagatcac aaagcttgtc gttgaaatga aaagttctat tgaaaaaata aaagaacaag 1521181 tgcaaaatat agaatagtga ctgtgcgtat tgtttacaga cggtcttact aggctaaact 1521241 agagacgtct attttacagg gggaacgtag aagatgacga ttaaactgat taatatcgga 1521301 tttggcaata tcatctccgc caatcggatg atttcgattg tcagcccgga gtctgcgcca 1521361 atcaaacgga tgattcagga tgcaagagac cgcggaatgc taattgacgc tacatacgga 1521421 cgaagaaccc gtgcagttgt cgtcatggat agtgatcaca ttatcttatc tgccgtccag 1521481 cctgagacag ttgcacacag actttctgtt aaagaagaaa ttatggatga agggcagggg 1521541 taattgccgc atgaaagaaa gagggttatt aatcgttctc tcaggtccct caggagttgg 1521601 taaaggaacg gttcgacaag cgatcttttc gcaggaagac acaaaatttg aatattcgat 1521661 ttcagtaacc acaagaagtc caagagaggg cgaagtgaac ggagtcgatt attttttcaa 1521721 aacaagagac gaattcgagc aaatgattgc ggacaacaag ctgcttgaat gggcagagta 1521781 tgtcggcaat tattacggca cgccagtcga ttatgttgaa cagacgcttc aagatggaaa 1521841 agacgtcttt ttagaaattg aagttcaagg ggctcttcaa gtgagaaatg ctttcccgga 1521901 aggcctgttt attttccttg cgcctccaag cctttctgaa ctgaaaaaca gaatcgtgac 1521961 acgaggaaca gaaacagacg ctctgattga aaatcgaatg aaagccgcaa aagctgagat 1522021 cgaaatgatg gatgcttatg actatgtcgt tgaaaacgat aatgtcgaaa cggcttgcga 1522081 taaaatcaaa gcaatcgttc ttgctgaaca tttgaagcgt gaacgcgttg caccaagata 1522141 taagaaaatg ctggaggttg aataatcaat gttagatccg tcaattgatt ctttaatgaa 1522201 taaattagat tcaaaatata cgctggtgac tgtttctgcg agacgtgccc gtgaaatgca 1522261 aatcaaaaaa gaccaaatga ttgaacatac gatttcacac aaatatgtag gcaaagcttt 1522321 agaagaaatt gatgcaggcc tgctttcgtt tgaaaaggaa gaccgcgaat agtagcacaa 1522381 gtagcaacct atatcatgta ggttgttatt tttttccgtg cggttttgta aagtgcagag 1522441 ggggagaatt cattgcttaa caatcgaaat gtgttacttt gcgtgagtgg aggcatcgct 1522501 gtttataaag cctgtgcgtt aacgagcaag ctggttcagg caggagcaaa tgtcaaagtg 1522561 attatgactg aatccgcttg ccgattcgtt tcaccgctga catttcaggc attgagccgc 1522621 cacgaagtct atacagatac atttaaagaa caaaatccaa gcgtcatttc tcatattgat 1522681 gccgcagact gggccgactt gattatcgta gcgccggcta cggctaatgt gattggaaaa 1522741 ctggcaaacg gcatcgctga tgatatgctg acgacaacat tgttggcagc aacggctccc 1522801 gtttggatcg cgccggcaat gaacgttcat atgtatgacc acccggcagt caaacgaaac 1522861 atttctgttc tttatcagga cggttattgt tttattgagc caagtgaggg ctatttagca 1522921 tgcggttacg taggaaaagg cagattggaa gagccggaaa acatcgtaaa gctggccgaa 1522981 aaacattttg ctgaagaaac atccgctcct ttagaaggca agcatgtggt cattacagcc 1523041 ggcccaacgc gggaagcgat tgatcctgtc cggtttttta ccaataaatc gacgggcaaa 1523101 atgggctacg cactggcgga ggctgctgtt cagctcggcg cacgggtaat cttaatttct 1523161 gggcctgttt cacttgatca gcctaaaggc cttgctgagt ttatccctgt tcaatcggct 1523221 gcggatatgc gcgaagctgt gctctctgtg tatgacgcaa gcgatatagt cattaaaaca 1523281 gctgcggtag ccgattttac gccgaaaaca gtatttgacc ataaaatgaa aaaacaagac 1523341 ggcggcatga ccttagaact gaaaagaaca gtcgatattt tgaaagaatt gggcgagaaa 1523401 aagaaagagc agattttggt cggatttgcc gccgaaacac aagacattga acactatgca 1523461 cgtaaaaagc tcgccgctaa aaaccttgat ttgattgtgg caaatgatgt gaaagcaaat 1523521 ggggccggtt ttggtgctga tacgaatatc gtgacaatct ttttcaaaga cgggcataaa 1523581 cgcgaactcc cgattatgtc taagctcgat gtttcttttg aaatccttca ggagatcgca 1523641 gccctctcaa aacaaaccgg agagcgctca tgaattttgc agaagtcatc gttgatgtca 1523701 gcaccaaaaa tatagacagg ccttttgatt ataaaatccc agaccatctg aagggcatga 1523761 tcaaaacggg gatgcgggtc attgttccgt ttggcccccg taagattcaa gggtttgtga 1523821 cagcagtcaa agaagcatct gacctatcgg gaaaatctgt caaggaagta gaggatttat 1523881 tagatcttac acctgttctg acagaggagc ttatgattct gtcatcatgg ctgtcagaca 1523941 aaacgctgtc ttttaaaata acggcgcttc aagcaatgct gcctgccgcc ttaaaggcga 1524001 aatatgaaaa agaattaaaa attgcacacg gagccgatct tccgccgcaa gtggaacggc 1524061 tgttttctga aacaaagacg ctgctgtatt cagatatacc cgatcatgag acgctgaaac 1524121 tgattcaaag gcatgttcaa aaaggggaca ttgacgtgac gtataaagtc gcgcaaaaaa 1524181 ccaataaaaa aatggtcagg catattcagg caaatgcgag taaagaagag cttgctaagc 1524241 aggctgaggg attgtcccgc caagcagcaa aacagcaggc gattcttcac tttctcatct 1524301 ctgagccgga aggtgtgaaa attcctgcgg cggaattgtg caaaaaaacg gacacgagct 1524361 ctgcaaccat caaaaccctt atccaaaaag ggcttttgaa ggaaagctat gaagaggttt 1524421 acagagatcc ctatcaggac aaaatgttca aaaaaacaga gcccctgccg ctgacagacg 1524481 aacagagggc tgccttcgag cccatacgcg agacattgga cagcgatgag cataaagtgt 1524541 tcctccttca cggcgtgaca ggaagcggaa aaaccgaaat ttatctgcaa tcaattgaaa 1524601 aagtactggc gaaaggaaaa gaagccatcg tcctcgtacc ggaaatatcg ctgacgccgc 1524661 aaatggtcaa ccgcttcaag ggccgcttcg gctcccaggt ggcagtcatg cacagcggtt 1524721 tatccacagg agaaaaatat gacgagtggc gtaaaatcca ccggaaggaa gtacggcttg 1524781 tcgtcggtgc cagatccgcc atttttgctc cgtttgaaaa tctcggaatg ataatcatcg 1524841 atgaagagca cgagtcttcc tataaacagg aagaaatgcc gcgctatcat gcgaaagagg 1524901 tggcaatcaa gcgggctgag catcacagct gcccggttgt attagggagt gctacgccga 1524961 cattagaatc atatgctaga gcgcaaaagg gcgtatacga gcttctttca ctgaagcacc 1525021 gtgttaacca tcgggtgatg cccgaggttt cgcttgtcga tatgagagag gagcttagaa 1525081 acggcaatcg ctcgatgttt tcagttgaat tgatggaaaa gcttgaagaa acgattgcca 1525141 agggtgagca ggcggtgctg tttttaaata agaggggcta ctcttccttt gtgatgtgca 1525201 gggattgcgg ctatgtcccg caatgcccgc actgcgacat ttccatgacg tatcatcgtt 1525261 acggccaaag gctgaaatgc cattattgcg gacatgaaga gcctgttccg cacacttgtc 1525321 ctgaatgcgc aagcgagcat atccgctttt tcggaacggg aacacagcga gtggaggaag 1525381 agctgacaaa agtgctgcca agtgcgagag tgattcggat ggatgttgac acgacatcac 1525441 ggaaaggcgc ccatgaaaaa ttactgtcag ctttcggaga aggaaaagcg gatattcttc 1525501 tcggaacgca aatgatcgcg aaagggcttg attttccgaa tgtcacgctt gtcggagtgt 1525561 taagtgctga tacaacactt catattcctg atttcagatc ggctgaaaaa acatttcagc 1525621 tgttaacgca agtcagcggc cgggcaggca ggcatgaaaa gcccggccat gtcatcattc 1525681 aaacgtatac accgtctcat tacagtatcc agctgacgaa aacacacgat tatgaaacgt 1525741 tctatcagca tgaaatggcg cacaggagag agcaatccta tccgccatac tactatttgg 1525801 ctcttgtgac tgtttctcat gaggaagtgg cgaaagcagc ggttacagct gaaaaaatcg 1525861 ctcatttttt gaaagcaaac tgcggagctg acacgaaaat tctcggacca agcgcgtcgc 1525921 cgatagccag gatcaaagat agatatcgct atcaatgcgt gataaaatac aaacaggaaa 1525981 cccagttatc cgctttattg aagaagatac tggaacatta taaacgcgaa attgaacaaa 1526041 aacatgtaat gatttcaatt gatatgaatc cttatatgat gatgtaagat ctcacgtctt 1526101 ggagggtaac aaattggcag taaaaaaggt cgtcacacat cctgcggagg ttttggaaac 1526161 acctgcggaa accgtgactg tttttgataa aaagctaaaa aaactgcttg atgatatgta 1526221 cgacaccatg cttgaaatgg atggtgtcgg actggcagcg ccgcaaatcg gcattttaaa 1526281 aagagcggcc gtcgtagaaa tcggggatga cagagggaga attgatctcg ttaatcctga 1526341 aattttagaa aaaagcggcg agcaaaccgg aattgaagga tgcttgagct ttcctaacgt 1526401 ctatggtgat gtcacacgtg ccgattatgt caaagtgcgt gcgtttaacc gtcagggaaa 1526461 accgttcatt ctggaagcgc gaggcttttt agcaagagcc gtgcagcatg aaatggacca 1526521 cttagacggt gtgctgttta catctaaaat aagtaaatac tatacagaag atgaactagc 1526581 ggatatggaa ggatgatttg atgacgagaa tcgtatttat gggaacgccg gatttttcag 1526641 ttcctgtttt aagaaccctg atagaggacg gatatgaagt agtgggggtc gtcacacagc 1526701 cggaccgtcc gaagggcaga aaaaaagtac tgacacctcc tccggtaaag gaagaggcat 1526761 tgcgccacgg catcccggtt cttcagccgg aaaaagtcag attgacagaa gaaattgaaa 1526821 aagtgctggc attaaagcct gacctgattg taacggcggc attcggacaa attttgccta 1526881 aagagcttct cgacagtcca aaatacggct gcattaacgt tcacgcatcc cttttgccgg 1526941 aactgcgcgg cggtgctccg atccattatt ccattctgca gggaaagaag aaaaccggga 1527001 ttaccattat gtatatggta gaaaaattgg atgcgggcga tatgatctca aaagtggaag 1527061 tggacattga agaaaccgac aatgtcggaa cactgcacga taaattaagc gttgctggcg 1527121 cgaagctatt gtctgaaacg gttccaaacg ttattgccgg cagcatatca cctgaaaagc 1527181 aggatgaaga gaaagcgacg tacgcgccta acattaaaag agagcaagag ctgctcgact 1527241 ggtccagaac gggcgaagag ctttacaacc agatccgcgg cttaaatcca tggcctgttg 1527301 cttatacgac tctaaacgga caaaacttga aaatatgggc gtcgaaaaaa atagcggcac 1527361 caacaacagc tgagcccggc acagtcgttg cagttgaaaa ggaaggaatt atcgttgcca 1527421 caggtaacga gacggctctg ttattaaccg aactccagcc ggcaggcaaa aaacgaatga 1527481 aaggcgaaga ctttgtgcga ggcgctcatg ttgaagccgg tgatgtgtta ggagtaaaca 1527541 atgaaaaaaa ctagtgttcg tgacatcgcc cttgaggcgc tgatcaaatt agaacaaaac 1527601 caggcataca gcaacctgct gctgaaatcg gtcattaaat caaatgaact gagtgatcag 1527661 aacagagggc ttttgactga acttgtctat ggtacattac aaaataagat cgcgcttgat 1527721 tatatgctta aaccgtttat caataagcct caaaaggtaa agccgtgggt gattcagctt 1527781 cttcgcctat ccttatatca aatggagtat ttggagaaga ttccagacag ggcagccatt 1527841 catgaagcgg ttgagattgc taaaatccgc ggacacaaag gcattgcttc atttgtcaac 1527901 ggcgtgctcc gttctattca gcgcgaaggt gttccatcct ttgacgcgat cgaagatcct 1527961 gtccgccggc tggcgacaga aacaagccat ccggaatggc ttgtgaaaga gtgggcggat 1528021 gcgtatggat ttgaagctgc ggaaaagatt tgccgcatcc atctcattcc gccgaaacag 1528081 acgctgcgtg tcaatcaaat gaaagcagac agagctgagc tgcttgacca aatggctgct 1528141 gagggaatcg aagttgaaaa aggcgacctc gctgaagatg ctgtgaagct cttaaaggga 1528201 acaattgccg gaactcattt cttccaaaac ggcgaagttt ctatccagga tgagagctcc 1528261 atgctcgtcg cccgcgccct tgatcctaag tcagatgaaa cagtgcttga cgcgtgtgcg 1528321 gcgcctggcg gaaagtcggc tcatatcgca gaattaatga agaacaaggg gagcgttacg 1528381 tcgcttgatc ttcacaaaca taaagtgaag ctgatcaaag aagcggcaga tcggcttggc 1528441 ctgacaatca ttcatgcgga aacaatggat gctagaaaag cgggggaaac gtttgaaaac 1528501 gaacagtttg accgaatatt ggtcgatgcc ccgtgctcag gtttcggtgt tatcagaaga 1528561 aagccggaca tgaaatacac gaaaaaacct gacgacagcg cccgtctagc tgaaatccag 1528621 ctgtcgatct tgagggaaat cgcaccatta gtaaaaaaag gtggcactct tgtctacagt 1528681 acgtgtacaa tggaccggac agaaaatgat gaagtaatac atgcgtttat acaagaacat 1528741 cctgattttg aacccgattt gtctcttgaa aagcggctgc ctgaaaaggt gagacccttt 1528801 gttcgggatg gaaggcttca aatccttcct cattatttcg gaacagatgg tttctttatt 1528861 tgcagcatga gaaagaaggg ataagcaatg gcagaactta ataaaacaaa agtaagaaaa 1528921 gaattgcgga cagagcgtcc gtctatttat tcttttgaat tagatgaaat caaacaatgg 1528981 ctgacagaca atggagagaa accgttccgt gcagcccaga tctttgaatg gctatatgaa 1529041 aaacgcgtat cttcttttga agatatgaca aacctctcaa aggatctgcg tgagaaatta 1529101 aacactcgct ttgtgttaac aacgctgaaa acggctgtta aacaaacctc tcaagacggt 1529161 acgatgaagt ttttgtttga gcttcatgac ggttatacca tcgaaaccgt tttaatgaga 1529221 cacgagtatg gcaattctgt atgtgtaacg acacaagtcg gctgccgtat tggctgcaca 1529281 ttctgcgcgt caacgcttgg aggcttaaaa cgaaaccttg aagcagggga aattgtcgct 1529341 caagtagtca aagtgcaaaa agctcttgat gaaacggatg aacgcgtcag ctctgtcgtg 1529401 atcatgggaa tcggcgaacc ttttgataac tttaacgaaa tgctcgcttt cttgaaaatc 1529461 attaaccatg acaagggcct gaatatcggt gctcgccata ttacggtctc tacgagtgga 1529521 atcatcccga aaatttacga atttgctgat cagcaaatgc agattaactt tgcaatttct 1529581 ctgcacgcgc cgaacacaga aatcagaagc cgtttgatgc cgattaacag agcatataaa 1529641 ctgcctgatc taatggaagc cgttaaatat tatattaata aaacaggacg ccgtatcagc 1529701 tttgaatacg ggctgttcgg aggcgtaaac gaccaggtgg aacacgccga agagcttgcc 1529761 gacttgctgg aaggagtcaa atgccacgtg aacttgattc cggtaaacta cgtgcctgaa 1529821 cgggactatg tgcgcacacc gcgtgatcag atttttgctt ttgaaaaaac gctgaaatcc 1529881 cgcggagtaa atgtcacaat ccgaagagag caaggacatg acattgacgc agcctgcggt 1529941 cagcttcgcg cgaaggagcg tcaagacgag acgaggtgat gagggttgtt aacagcctta 1530001 aaaacagata caggaaaaat ccgccagcat aatgaagatg atgcggggat attcaagggg 1530061 aaagatgaat ttatattagc ggttgtcgct gatggcatgg gcggccatct tgctggagat 1530121 gttgcgagca agatggctgt gaaagccatg ggggagaaat ggaatgaagc agagacgatt 1530181 ccaactgcgc cctcggaatg tgaaaaatgg ctcattgaac agattctatc ggtaaacagc 1530241 aaaatatacg atcacgctca agcccacgaa gaatgccaag gcatggggac gacgattgta 1530301 tgtgcacttt ttacggggaa aacggtttct gttgcccata tcggagacag cagatgctat 1530361 ttgcttcagg acgatgattt cgttcaagtg acagaagacc attcgcttgt aaatgaactg 1530421 gttcgcactg gagagatttc cagagaagac gctgaacatc atccgcgaaa aaatgtgttg 1530481 acgaaggcgc ttggaacaga ccagttagtc agtattgaca cccgttcctt tgatatagaa 1530541 cccggagaca aactgcttct atgttctgac ggactgacaa ataaagtgga aggcactgag 1530601 ttaaaagaca tcctgcaaag cgattcagct cctcaggaaa aagtaaacct gcttgtggac 1530661 aaagccaatc agaatggcgg agaagacaac attacagcag ttttgcttga gcttgcttta 1530721 caagttgaag agggtgaaga tcagtgctaa tcggcaagcg gatcagcggg cgttaccaaa 1530781 ttctccgcgt cataggcggc gggggaatgg ccaacgtgta tttagctgag gatatcattc 1530841 tagaccgtga agtcgcaatt aaaatcctgc ggtttgacta tgcaaatgac aatgaattta 1530901 tcagacgttt ccgcagagaa gcccaatccg catcaagcct cgatcacccg aatattgtca 1530961 gcatttatga tttgggcgag gaagatgata tttattatat tgtcatggaa tacgttgaag 1531021 gcatgacgct taaagaatac ataacagcaa atgggccgct tcaccctaaa gaagcgctga 1531081 acatcatgga gcaaattgtc tcagccatcg ctcatgccca tcaaaaccag attgttcaca 1531141 gagacatcaa gccgcataac attttgattg atcatatggg aaatatcaaa gtaacggatt 1531201 ttggaattgc gacggcacta agttcgacca caatcaccca taccaattca gttctgggct 1531261 cggtccatta cttatcacct gaacaggccc ggggcggctt agccacaaaa aaatcggata 1531321 tttatgcgct tggaatcgtt ctatttgagc ttttaaccgg ccgtattccg tttgatggag 1531381 agtcagcagt cagcatcgcc ttgaagcatc ttcaagcgga aactccttcg gcaaaaaggt 1531441 ggaatccatc ggtcccccaa agcgttgaaa acatcatact caaggcaact gccaaagatc 1531501 cttttcatcg ctacgaaacg gctgaagaca tggaagcaga cataaaaaca gcttttgatg 1531561 ccgacagact caatgaaaag agatttacga ttcaagaaga tgaagaaatg acaaaagcga 1531621 tacctatcat taaagatgaa gaacttgcta aagctgctgg cgaaaaagaa gctgaagtga 1531681 caaccgcaca agaaaacaaa acaaagaaga acggcaaaag aaaaaagtgg ccgtgggttt 1531741 tgctcacgat atgcctcgtt tttatcacag ctggaattct tgctgtcact gtttttccgt 1531801 cgcttttcat gcctaaggat gtcaaaatac ctgatgtctc cggaatggaa tacgaaaaag 1531861 ccgcagggct cttggaaaaa gaaggtttac aggttgattc cgaggtgttg gaaatctcag 1531921 atgaaaaaat tgaagagggc ctgatggtaa aaacggatcc taaagcggat accacagtca 1531981 aagaaggcgc cacggtcacc ctttataaga gcaccggaaa agcaaaaacg gagatcggtg 1532041 atgtgacagg ccaaacggtc gaccaagcaa aaaaagcgtt gaaggaccaa gggtttaatc 1532101 atgtaacagt aaatgaagtg aatgacgaga aaaatgcggg cactgtcatt gaccaaaatc 1532161 cttcagcagg gactgagctg gtcccgagtg aagatcaagt caaacttaca gtcagtatcg 1532221 gacccgaaga cattacgctt agagacttga aaacctacag taaagaagca gcgtctggat 1532281 atctggaaga caacggattg aagcttgtag aaaaagaagc atactcagat gatgttccag 1532341 aaggacaggt tgtcaaacaa aaaccagcag caggtacggc agtaaagccg ggaaacgaag 1532401 ttgaagtgac attctctctc ggaccagaga aaaaacctgc gaaaacagtg aaagaaaagg 1532461 tcaagatccc ctacgaacca gaaaatgaag gggacgagct tcaagtgcaa atcgcggttg 1532521 acgatgcgga tcacagcatc tctgacactt acgaagaatt taagataaaa gagccgactg 1532581 aacgaacgat cgaactaaag attgaaccag gccaaaaagg gtactatcaa gtaatggtaa 1532641 acaataaagt tgtcagctac aaaaccattg agtatccgaa agatgaataa caaggaggga 1532701 aaatatgcct gagggcaaaa ttattaaggc gctaagcggc ttttactatg tactggatga 1532761 atcagaggat tcagataaag taatacaatg cagaggaaga ggcattttca gaaaaaacaa 1532821 aattacccct cttgtcggtg attacgttgt gtatcaagct gaaaatgaca aagaaggata 1532881 tctaatggaa attaaagaaa gaaccaacga gcttatcagg ccgccaattt gcaacgttga 1532941 tcaagcggtc cttgttttct cagcggttca gccttctttc agcacggcat tgctcgaccg 1533001 cttcctggtt ctcgttgagg ccaatgatat tcagccgatt atatgcatta ctaaaatgga 1533061 tctgattgaa gatcaagata cagaagatac gatacaagcc tatgcagaag actatcggaa 1533121 tattggttat gacgtatacc ttacctcctc taaggaccaa gatagtttag cggacatcat 1533181 cccgcatttt caggataaaa caacggtatt tgccggtcag tccggtgttg ggaaatcctc 1533241 gcttctcaac gcgatcagtc cggagctcgg attaagaaca aacgagattt ccgagcattt 1533301 gggccgcggg aaacacacaa cccgccacgt ggagctgatt cacacgtccg gaggtttggt 1533361 tgcagataca ccgggattca gctcgcttga atttacagac attgaggaag aagagctggg 1533421 ctataccttc cctgatatca gagaaaaaag ctcttcatgc aaatttagag gctgtttaca 1533481 tctgaaagag ccgaaatgtg cggtgaaaca agctgttgaa gacggggaat taaagcagta 1533541 tcgctatgac cattatgttg aatttatgac ggagattaaa gacagaaagc cgaggtatta 1533601 gcataatgat aaaggttgca ccatctattc tttccgctga ttttgccgct ttaggcaatg 1533661 agattaaaga tgtagaaaaa ggcggagccg attgtattca tattgatgtt atggacggcc 1533721 attttgtccc gaatatcaca atcggtccgc tgattgtaga agcggtccgg ccggtaacgg 1533781 atctgccgct tgatgtccat ttaatgatag aagagccgga tcgttatatc ccggcttttg 1533841 cgaaagcagg cgcagatatc ctgtctgtgc atgctgaggc atgtccgcac ctgcaccgta 1533901 ccatccagct cattaaagag caaggagtga aggccggagt agttctaaac ccgcataccc 1533961 ctgtacaagt catcgaacat gttttcgacg atcttgatct tgttctttta atgacggtga 1534021 acccgggctt cggcgggcag aaatttattc attcagtcct tcctaaaata aaagaggtta 1534081 agcgaatggc ggatgaaaaa ggaaaaaaag atctgttaat tgaagtagac ggcggcgtca 1534141 acaaagaaac cgctccgctc gtcattgaag cgggcgcaaa tttactcgtt gccggttcag 1534201 ctgtttatgg ccagtctgac cgcaaaaaag caatttctga aatcagagga agtaaataag 1534261 cagctttaga aaagagctgg gcatacaata gcctaagctc tttttcctgt atgcagagaa 1534321 aggaatcaga gatgaaaaca attaatatcg ttgcgggagg cccgaaaaat ctcattcccg 1534381 atctaaccgg ctatacggat gaacacacgc tttggatcgg tgttgacaaa ggcaccgtca 1534441 ctctcttaga tgccgggatc attcctgttg aagccttcgg agattttgac agcataacgg 1534501 agcaagaacg ccggcgaata gaaaaagccg ctcccgccct tcatgtgtat caagcagaaa 1534561 aagatcaaac agatttagac ctcgcccttg attgggcgct ggaaaagcag ccggatatta 1534621 ttcagatttt cggcattaca ggcggcagag ctgatcattt tttaggaaac attcagcttc 1534681 tgtataaagg tgtaaaaacg aacataaaaa ttaggctgat agacaaacaa aatcatattc 1534741 aaatgttccc tcctggtgaa tatgatattg agaaggatga aaataagcga tatatctcct 1534801 tcataccgtt ttccgaagac atacatgagc tgaccctgac cggttttaaa tatcctctaa 1534861 ataattgtca tattacgctc ggttcaacac tatgtattag taacgaactc attcattcac 1534921 gaggtacttt ttcgtttgca aaaggcatat taataatgat aagaagcacg gattaagcat 1534981 gtgctttcat tcaattgctg aaaacaatga acaaggcggt tacgggacgt tataggaggg 1535041 gacaaaaatg aaattttaca ccattaaatt gccgaagttt ttaggaggaa ttgtccgggc 1535101 gatgctgggc tcatttagaa aagattaatg cccaggggtt caaagccctc tttcaccaca 1535161 taaaaacgcc tgccacatat cggggcaggc gttcattttg ttatacacgc tcaactttac 1535221 cggatttcaa agctcgagca gatacatata cttttttagg ttttccgttc acaaggatac 1535281 gaaccttttg aagattcgcg ccccaagtgc gcttagaagc gttcattgcg tgagaacggt 1535341 tattcccagc tgttgttttt ttacctgtga taacgcattt acgtgccatt tgtttccctc 1535401 ctcacttgca caaaacatct actttttaac attcatataa tcttagatgc tttcgatatg 1535461 gatactttaa ataatttacc acagctaaaa aacgtttgca actattgttt catcatcttt 1535521 caagaaaatt cacttgacat cttgcggaaa cagcagcgct atagtatatg tagaggtacg 1535581 gccagcgatt attgcctggt cttttcataa tggaaaccat atagtagaat agctgtaact 1535641 ctatgcattc gaaggaggaa ctagtgtgtc cattgaatta agaacgaagt acggacagat 1535701 tgatatatct aatgaagtca tcgcgatggt tgcaggaggc gcggcggttg actgttacgg 1535761 cattgtcggc atggcctcta aaaaccagat taaagacgga ctgactgaaa tccttcggaa 1535821 agagaatttc agcaggggtg tccaagttcg ccaagaagga gaacagatac atatcgacat 1535881 gtatatcatt gtcagctacg gcacgaaaat ttctgaagtg gcacataatg tccaaacaaa 1535941 agtaaagtac acagtaaatc aaaccatcgg actggcagtg gattctgtca atatttatgt 1536001 ccaaggcgta cgagtgacga acccgtagtt aggaggagta ggattgtcta tcagaacatt 1536061 agacggcaga acctttgccg agatgattct tgcgggagcg cagaatctgt ctcaaaacgc 1536121 cagtgcagtt gatgcactga acgtgttccc ggtgccggac ggtgatacgg gaacaaatat 1536181 gaacctgtcg atgacttccg gagcaagaga agttgaacaa atggatacgg atgatatcgg 1536241 gaaggtgggc tccgcgttat ctaaagggct gctcatggga gcacgcggaa attcaggagt 1536301 tatcctatcc caattgttcc gcggatttag caaaaacatt gaaacgaaaa aagaaattaa 1536361 tgcacttgag tttgccgctg cgctgcaagc aggtgtagac atggcgtata aagctgtcat 1536421 gaaacctgta gagggcacca ttttaacagt tgcaaaagac gctgcaaaaa aagcaatgat 1536481 cttagcagaa aaagaaaccg atatcactgc gctgatgact gcagtgacag aagaagcaga 1536541 ggcgtcttta aaccgcaccc ctgaattgct acctgtccta aaggaagtag gagttgtcga 1536601 tagcgggggc aaaggcctgc tctgtgtgta tgaaggtttc cttgcttcat taaaaggtga 1536661 aactgtacct cagaaagcag ttcttccgtc acttgacgac atggtcagcg cagagcatca 1536721 caagagcgcg caaagcatga tgaataccga agatattgaa tttggattct gtaccgaagt 1536781 gatggttagg cttgatcaga caaaaagaga gttcgacgaa ggcacgttca ggcaagacct 1536841 cagccagttc ggagattctc tgcttgtgat tgcggatgaa tcgctggcga aggttcatat 1536901 tcatgctgaa gagccgggaa acgtgttaaa ctacgcccag cattacggtg aattgatcaa 1536961 aataaaaata gaaaatatga gagaacagca tacctctatc atcagtcaag aaagcaaacc 1537021 tgcagacaac gaaacaccgc cggcaaaaca gccgtatggc attgtgactg tagcgatggg 1537081 agaaggaatt gcagacctat ttaaaagcat tggcgcttct gttgtgattg aaggcggcca 1537141 gaccatgaac ccaagcactg aggatattgt tgatgccgtg aagtctgtaa atgcagatac 1537201 ggtatttatc ctgcctaaca actccaacat tatcatggct gctaaccaag cggccagcgt 1537261 agtggatgaa caggtttttg tcattcctgc taaaacggtt ccgcaaggga tgtcagctct 1537321 gctggctttt aacccggatc aagaagctga agcgaacgag gccaatatgc taagcgccat 1537381 tcagcaagta aaaagcggac aggtgacgtt ctcagtcaga gatactcata ttgacggtaa 1537441 agacattaaa aaaggcgact ttatgggcat tctgaatgga acgattatcg gcacttctga 1537501 aaatcagctg tcagccgcga aaatgctgct gtcagaaatg atcggagaag atgatgaaat 1537561 cgtgaccatt ctatatggtg aggatgcgtc tcaggaagaa gctgagcagc ttgaagcgtt 1537621 tctcagtgaa aagtacgagg agattgaggt tgagatccac aatgggaaac agcctctgta 1537681 ttcgtatata gtttcagcag aatagaaggg caatttgccc ttctattctt atgtctgctt 1537741 ttaagtgcgg cagcgctgta acgcgcccgc ttgccatttt atatctgatc aattagtcta 1537801 gaagcaaagc gctaataagc tctggttcat aaggaggaat agcatgaaat acagaagcgt 1537861 ttttgatatt atcggcccgg ttatgatcgg tccgtccagc tctcatacag cgggagctgc 1537921 tagaatcggg agagtggcca gaagtttatt tggcagagag cctgagcgca tcattgtatc 1537981 tttttacggc tcgtttgcgg aaacgtataa gggccacggc acagatgtcg cgattatcgg 1538041 cggattgctt gattttgata cattcgatga acggattaaa accgctatac aaattgcaga 1538101 agctaaagga attgatatag agtttcgggt agaagacgca gtcccggtcc acccgaacac 1538161 agcaaaaatc accatttctg atgaaaaggg tgagctggaa ctgacgggta tttcgattgg 1538221 cggaggaaag attgaaatca cagaattgaa tggttttgag ctccggctgt caggaaatca 1538281 tccggccata ttagttgttc ataatgacaa gtttggcaca attgccggtg ttgccaatgt 1538341 tctggcgaaa ttttcaatca acgtaggaca tatggaagta gcccggaaag atatcggcca 1538401 gcttgcgctg atgacaatag aggtcgatca aaatattgac gaccacattc tcgacgagct 1538461 gtcgaagctg ccgaatatta ttcaagtgac aaagattgct gactagcgaa aagggtcagg 1538521 aggagccagt tatgtttcgt aatgtaaaag aattaattga gattactaaa gaaaaacaaa 1538581 tattgatctc tgatgtgatg atagctcaag agatggaagt aacagaaaaa acaaaagagg 1538641 acatttttca gcagatggat cataacctgt ctgttatgga agcggcggtt cagaaaggac 1538701 tcgagggagt tacgagccaa acgggcttaa caggcggaga tgccgttaaa ttgcaggcct 1538761 atattcgatc aggaaaaagc ctgtctggcc cgctgatttt agatgctgta tcgaaagccg 1538821 ttgcaacaaa tgaagtaaat gcagccatgg gaaccatctg tgcgacaccg actgcaggtt 1538881 ctgccggtgt ggtgcccggt acgttatttg ctgtaaaaga aaagctgaat ccaacaagag 1538941 aacaaatgat ccgctttttg tttacagccg gggctttcgg atttgtcgtg gccaataacg 1539001 caagcatttc cggcgccgcc ggaggatgtc aggcagaggt tggatcagct tcaggcatgg 1539061 cggctgcggc tattgttgaa atggcaggag gaacacccga acaaagcgcg gaagccatgg 1539121 ccattacatt aaaaaatatg ctaggcctcg tgtgcgaccc tgttgcaggg cttgttgagg 1539181 tgccttgcgt gaaacggaat gcgatgggcg cgtcaaatgc gatgattgct gctgatatgg 1539241 cattggcggg cattacaagc cgtattccat gtgatgaggt tatcgatgcc atgtataaaa 1539301 taggccaaac gatgccaact gcacttagag aaacaggcca gggcggttta gcggcaacac 1539361 cgacaggaag agaattagag aaaaaaattt tcggaggagc gctaggttca cgtgaaacaa 1539421 catcagcaaa ctagtatagc taacattaag ggtattgggc cggaaacaga aaaaacattg 1539481 aatgaactcg gtatttatga catttctgat cttctgaatt atttccctta tcgctatgat 1539541 gactacgagc tgagggattt agaagaagta aagcatgatg aaagagtcac agtcgaaggg 1539601 aaggttcatt cagagccttc tcttacctat tacggaaaaa aacgaaacag gctgacattc 1539661 aggcttctgg tcggccacta tttaatcaca gccgtatgtt ttaaccggcc ttatttgaag 1539721 aagaagcttt cgctcggctc tgtggtgacg gtttcaggta aatgggacaa gcaccgccaa 1539781 accatctctg ttcaggagtt gaaaaacggg ccgcatcaag aagacaaaag cattgaacca 1539841 gtgtattctg tgaaagaaaa tgttaccgtc aaaatgatga ggcgctttat tcagcaggcg 1539901 ctgacccaat atgcagactc acttcctgat cctcttccgg aaaagctaag aaaaagctat 1539961 aaactgcctg actattatca agcgttaaaa gcaatgcacc agcctgaaac aagggaagca 1540021 ttaaagcttg ccagacggcg gtttgtttat gaagaatttt tgttgtttca gttgaaaatg 1540081 caggcgttcc gaaaggcgga aagagagcag acacaaggga tacggcagcg tttttcaaac 1540141 gaagaactca tgagatttat caaaagcctc ccgtttcccc tcacaaacgc ccagtcacgc 1540201 gttcttcgcg aaataacagc agacatgtct tctccataca gaatgaaccg tcttcttcaa 1540261 ggggacgttg gatcaggaaa aacggcagtc gccgccattg cactgtatgc cgcgatccta 1540321 tccggatacc aaggagcgct catggtgccg acagaaattc tggccgagca gcatgctgat 1540381 tcgctcgttt cgctatttga aaaatgggac gtcagcgttg ctcttttgac aagctctgtt 1540441 aaaggaaagc ggcgaaaaga actgcttgag cgtcttgcgg cgggtgagat tgatattctt 1540501 gtaggaaccc atgctttaat ccaagacgag gtggagttta aggcgttgag tctcgttatt 1540561 actgatgaac agcacagatt tggagttgag cagcgcaaaa agcttcggaa caaagggcag 1540621 gatcccgatg ttctctttat gacagccact ccaatcccaa gaacattagc gatcacagta 1540681 ttcggtgaaa tggatgtatc tgtcattgat gagatgccgg ctggacgaaa gcgaattgaa 1540741 acctattggg taaaacatga catgcttgat cgtattttgg catttgtcga aaaagaatta 1540801 aagcaaggca ggcaggctta tatcatctgt ccgctgattg aagaatcaga taagcttgat 1540861 gtgcaaaacg ccattgacgt gtacaatatg ctttctgata tttttcgggg aaaatggaat 1540921 gtcggcctta tgcatggaaa gctgcattcc gatgaaaaag atcaggtcat gagagaattc 1540981 agcgcaaatc actgtcaaat tctcgtatca accactgttg tggaggttgg cgtaaatgtt 1541041 ccgaatgcaa caattatggt gatttatgac gccgaccgtt tcggactatc acagcttcac 1541101 cagctgcgcg gccgtgttgg acggggtgag catcaatctt tctgtattct gatggctgat 1541161 ccaaaatcag aaacagggaa agaacggatg aggatcatgt cggagaccaa tgacggtttc 1541221 gagctgtctg aaaaggatct ggaactgaga ggtcccggtg atttcttcgg gaaaaaacaa 1541281 agcggaatgc cggaatttaa agtggcggac atggttcatg attacagagc gcttgaaacg 1541341 gcaaggcagg atgctgcgaa tcttgtggct tctgacgcgt tctggaagga gccggaatac 1541401 gctgtgttaa gagatgaatt gctgaagagc ggagtaatgg acggggaaaa attaagctga 1541461 gtatcagaag tttttggtgt tcagccagaa acaatcgttg cattccaatc tatgaaatta 1541521 tatactacta ttagtaccta gtcttaattg tccggatggt gtttagatat gagaagaaat 1541581 aagagagaac gccaggaatt acttcagcag acgattcaag caaccccctt tattacagat 1541641 gaagaactag cgggtaaatt cggggtgagc atccagacga tacgtttgga ccgcttagag 1541701 ctttccatac ctgaactgag agaaagaatt aagaacgtgg cagagaaaac acttgaggac 1541761 gaagtgaagt ccctgtcact tgatgaagtt atcggagaaa ttattgacct tgagctggat 1541821 gatcaggcga tatccatttt agaaataaaa caggagcacg tgttcagccg gaatcagatt 1541881 gcgagaggac accatttatt tgcacaggcg aattctttgg ccgttgcagt cattgatgac 1541941 gagctggcgc tgactgcaag tgcagacatc cgctttacaa gacaggtaaa gcagggtgaa 1542001 cgtgtcgtag caaaagcgaa agtgacggct gtcgaaaaag aaaaaggaag aacggttgtc 1542061 gaagtgaaca gctacgttgg cgaagaaatt gttttttctg gacgctttga catgtatcgt 1542121 tcaaaacatt cataaaggtg gagcatgcat gagaatagct gtagatgcaa tgggaggaga 1542181 ccacgctccc aaagctgtta ttgacggagt tataaaaggt atagaggcat ttgatgatct 1542241 ccatatcaca cttgtcggtg acaaaacaac gatagaatca catttaacaa ctacatcaga 1542301 tcgcatcacg gtgctgcacg cagatgaagt gattgagcct acggatgaac cggtccgtgc 1542361 cgtgcgaaga aaaaagaact catctatggt tcttatggcg caggaggttg cggaaaacag 1542421 agctgacgcc tgcatttcag cgggaaatac cggtgcatta atgacagccg gtctctttat 1542481 tgtcgggaga attaaaggaa ttgaccgtcc ggcgcttgct ccgacacttc cgactgtttc 1542541 gggagacgga tttcttctcc ttgatgtcgg cgccaatgtc gatgccaaac cggagcacct 1542601 cgttcaatat gccatcatgg gttctgttta ttctcagcaa gtgcgcggtg tcacttcacc 1542661 gagagtcgga cttttaaatg tcggaacaga agataaaaaa ggaaacgaac tgacgaagca 1542721 gacgtttcaa attttaaaag aaacagcaaa catcaatttt atcggaaacg tggaagcgcg 1542781 agacctttta gatgatgtgg cggatgttgt agtaacagac ggctttaccg ggaatgttac 1542841 actcaaaacg ctggaaggct ctgcgttgtc aatttttaaa atgatgagag acgtaatgac 1542901 gtctactttg acatccaagc ttgcagcagc tgtgctgaaa ccaaaattga aagaaatgaa 1542961 aatgaaaatg gagtattcga attatggcgg agcaagtctt tttggcttaa aagcgcctgt 1543021 gatcaaggcg cacggctctt cagattcaaa tgctgtattc catgcgattc ggcaagcaag 1543081 agagatggtc agccaaaatg tggctgcgct cattcaggaa gaagtgaaag aagaaaaaac 1543141 agatgagtag tctggaggtt tttacatcat gagtaagatt gcatttttat tcccgggtca 1543201 gggatcacaa tttatcggca tgggaaaaga gctttatgag caggtgcctg ctgcaaagcg 1543261 tctgtttgat gaagccgatg aaacgttgga aacaaaactc agctcgctta tttttgaggg 1543321 ggatgctgaa gaattaacac ttacatacaa tgcgcagcct gctttgctta cgacaagcat 1543381 cgctgttctt gagaaattta aagaatctgg cattacacct gatttcacag caggacacag 1543441 ccttggtgaa tattctgcac tggttgcggc tggcgctctg tctttcaaag atgctgttta 1543501 tactgtcaga aagcgcggag agtttatgaa tgaagcggtg ccggctggcg aaggagcaat 1543561 ggctgcgatt ctcggcatgg atgctgaagc attaaagcaa gtaaccgata aagtcacaga 1543621 ggaaggcaac cttgtacagc ttgcgaatct caactgtcct ggccaaatcg tcatttccgg 1543681 aacagctaaa ggggttgagc ttgcatctga actggcaaaa gagaacggcg caaaacgcgc 1543741 aattccgctt gaagtaagcg gtccgttcca ttctgaactg atgaaaccgg ctgctgaaaa 1543801 gctgaaagag gtattggacg cctgtgacat aaaagacgct gacgttccgg tcatctcaaa 1543861 tgtttctgct gacgtgatga ctgaaaaagc agatatcaaa gaaaaactta ttgagcagct 1543921 ttactctccg gttcgttttg aggaaagcat taacaagctg atcgcagagg gtgttacgac 1543981 ttttattgaa atcggtcccg gaaaagtgct ttcaggcctt gtgaaaaaag tgaatagacg 1544041 gttaaaaaca attgctgtat cagatccgga aacgatcgag ctggcaattc aaacgcttaa 1544101 ggaggagaat gataatgctt aatgataaaa cggctattgt cactggcgca tcccgcggaa 1544161 tcggccgctc aatcgccctt gatctggcaa aaagcggagc aaatgttgtc gtgaactact 1544221 ccggcaatga agcgaaagca aatgaagtgg tagatgaaat caaatcaatg ggcagaaaag 1544281 caattgctgt aaaagcggat gtatcaaatc ccgaagatgt acaaaacatg ataaaagaaa 1544341 cattgtctgt tttttctacg attgacattc tggttaataa tgcgggaatt acaagagaca 1544401 atctcatcat gagaatgaaa gaagacgaat gggatgacgt cattaacatt aacctgaagg 1544461 gtgttttcaa ctgcacaaaa gctgttacaa gacaaatgat gaaacagcgt tcaggccgca 1544521 ttattaacgt atcgtctatc gtcggcgtca gcggaaaccc tggacaagcc aactacgtgg 1544581 ctgcaaaagc cggcgtcatc ggtttaacca aatcttctgc taaagagctc gccagccgaa 1544641 atattacggt aaacgcaata gcgccaggat ttatctcaac tgatatgaca gataaacttg 1544701 caaaagacgt tcaagacgaa atgctgaaac aaattccgct cgcgcgcttt ggtgaaccta 1544761 gcgatgtcag cagtgttgtc acgttcctag cttcagaggg agctcgttat atgacaggcc 1544821 aaacgcttca tattgacggc ggaatggtga tgtaagtttt ttctcgaaaa tttcatcgta 1544881 gtttctctag ttttttaaaa acgaatccac tataatactt gaggggaggt gaattgctat 1544941 ggcagacaca ttagagcgtg taacgaaaat catcgtagat cgccttggcg ttgatgaagc 1545001 agacgtcaaa cttgaagctt ctttcaagga agacttaggt gctgattccc tagatgtagt 1545061 tgagcttgtt atggaacttg aagacgagtt tgatatggag atttctgacg aagatgctga 1545121 aaagattgca acagtcggcg acgctgtgaa ctacatacaa aaccagcaat aagctgatgc 1545181 taaaagtccc gccgaaacgc ggggctttag ccctttattc gtgcagttat tacagcatgc 1545241 cgcttttacg cgcgctgtat ccggtttagt cagagaagcg cggtgaacct gatgtgccta 1545301 tggaggttac tatgtcaaaa cactcacatt ataaagataa aaaaaagttc tataaaaaag 1545361 tagaacaatt taaagagttt caagaacgga tttcggttca ctttcaaaat gaaaagcttt 1545421 tgtatcaagc atttacacat tcatcttatg tgaatgagca tcggaaaaag ccgtatgaag 1545481 ataatgaaag gcttgaattt ttaggtgacg ctgttttgga actgacgatc tccagattct 1545541 tatttgccaa atacccggct atgagtgaag gagatttgac gaaattgaga gccgcaattg 1545601 tttgcgaacc gtctctcgtt tcattggctc acgagctgtc attcggcgat cttgtcctgt 1545661 tgggtaaagg cgaggaaatg acaggcggaa gaaagcgtcc tgctctattg gcggatgttt 1545721 ttgaggcatt tatcggagcc ttgtaccttg accaaggatt agagccggtc gaaagtttct 1545781 taaaagttta tgtgttccct aaaattaacg atggtgcttt ttctcatgtg atggatttca 1545841 aaagccagct gcaggaatac gtgcagcggg acggcaaagg ctctctggag tataaaatct 1545901 ccaacgaaaa aggacctgcg cacaaccgtg aatttgaagc catcgtatct ctaaaaggtg 1545961 aaccactcgg agtcggaaac ggccgttcaa agaaagaagc cgaacagcac gctgctcagg 1546021 aagctttagc taaattgcaa aaacaccata cgaaacaata aaatccccct tatgactcag 1546081 ggggatttca gtatgtatgc cgtcttattt gaccaatgtt tatgatagaa ttgaaatact 1546141 tattacataa ggaggatcgc tatgttcctc aaacgtttag acgttatagg atttaaatca 1546201 tttgcagaac ggatttccgt agacttcgtt aaaggcgtga cagcagttgt cgggccgaac 1546261 ggaagcggaa aaagcaacat cacggatgcc attcgctggg ttctcggcga acaatcggca 1546321 cgctctcttc gcggcggaaa aatggaagac atcatttttg ctgggagtga ttcaagaaag 1546381 cgattaaatc tagctgaagt tacgcttact cttgataatg atgatcattt cttgccaatt 1546441 gacttccacg aggtgagtgt cacaagacgt gtgtacagat caggtgagag tgagtttctg 1546501 attaacaatc agccatgccg cttgaaagat attattgatt tatttatgga ctctgggctt 1546561 ggtaaagaag cattttctat tatcagccaa gggaaagtgg aagagatcct gagcagcaaa 1546621 gcggaggatc gccgcagtat ctttgaagaa gcggccgggg tgcttaaata taaaacgaga 1546681 aagaaaaaag cagaaaataa actgtttgag acacaggaca atctaaatcg ggtagaagat 1546741 atattacatg agcttgaagg acaggttgaa cctcttaaaa ttcaagcttc aatagcgaaa 1546801 gactaccttg agaaaaagaa agagctggag catgttgaaa ttgcgctgac tgcctatgat 1546861 atcgaagagc tgcatggtaa atggtcgact cttaaagaga aagtgcagat ggcaaaagaa 1546921 gaagagcttg ctgaatcgtc tgctatttct gcgaaagaag caaagattga ggatacaagg 1546981 gacaaaatac aagcgcttga tgagtcagta gatgagctcc agcaagtttt actggtaact 1547041 agtgaagagc tggaaaagct tgaaggccgt aaagaagtcc tgaaagaacg aaagaaaaac 1547101 gctgtgcaaa accaagaaca gcttgaagaa gccatcgttc agttccagca aaaagaaacg 1547161 gttctgaaag aagagctttc gaagcaggaa gctgtcttcg aaacgcttca ggctgaggtg 1547221 aagcagttaa gggcgcaagt aaaagaaaaa cagcaggctc tcagtcttca caatgaaaat 1547281 gtcgaagaga aaatcgagca gctgaaaagt gattattttg agctgttaaa cagccaggct 1547341 tcgatacgca acgaactcca gcttcttgat gaccagatgt cccaatccgc tgtcacattg 1547401 cagagacttg cggacaacaa tgaaaagcac ctgcaggaac ggcatgatat ttctgcgcgt 1547461 aaagccgcat gtgaaacgga atttgcccga attgagcagg agattcacag tcaagtcggt 1547521 gcatatcgtg atatgcagac aaaatatgag cagaaaaagc gccaatacga aaaaaatgaa 1547581 tccgctctgt atcaggcata ccaatacgtt cagcaagcga gatcaaaaaa ggacatgctt 1547641 gagacgatgc agggagattt ctccggcttt tatcaaggtg ttaaagaagt gctgaaagcg 1547701 aaagagcgcc ttggcggaat tcgcggagcg gttcttgagc tgatttctac agaacagaag 1547761 tatgaaacgg ccattgaaat agcgctcggc gcttctgctc aacacgtcgt gaccgacgat 1547821 gaacaatctg cccgcaaagc gattcaatat ttaaagcaga attccttcgg ccgggcgacg 1547881 tttctgcctc tttctgttat tagagaccgc cagcttcaaa gccgtgacgc ggaaacagcc 1547941 gcccggcatt catcatttct cggggttgcc agtgaacttg tcacatttga tcctgcgtat 1548001 cgaagcgtca tccagaatct tcttggaacc gttctgatca cagaggactt aaagggtgca 1548061 aacgagcttg cgaagcttct cgggcaccgg taccgcatcg taacccttga gggagatgtt 1548121 gtgaaccccg gtggttcaat gacgggcggc gcggttaaaa agaaaaataa ctccctcctt 1548181 ggaagaagcc gggagctaga agatgtgacg aaacggctcg ctgaaatgga agagaaaacg 1548241 gcactgcttg aacaagaggt caaaaccctt aagcactcca ttcaggatat ggagaaaaaa 1548301 ctggctgact taagagaaac cggggaaggc ttaaggttaa agcagcagga tgtgaaaggc 1548361 cagctgtacg aacttcaagt tgccgagaaa aatatcaata cccatttaga gctctatgat 1548421 caagaaaaat ctgctctgtc agaaagcgat gaagagagaa aagtgcgcaa acgcaagctt 1548481 gaagaagagc tctctgccgt atctgaaaag atgaaacagc ttgaagagga catagacaga 1548541 ctgacaaaac aaaaacaaac gcaatcctca acgaaagagt ctctctccaa cgagctgact 1548601 gagctgaaga tcgcagcggc caaaaaagag caggcttgca agggggaaga ggacaacctt 1548661 gccagattaa agaaagagct cactgaaaca gagcttgcgt taaaagaagc aaaagaagac 1548721 ttaagcttct taacgtcaga gatgtcatct agcaccagcg gcgaagaaaa gctggaagaa 1548781 gcagcaaaac ataaattgaa tgacaaaacg aaaacgatcg aactgattgc attaaggcgc 1548841 gatcagcgca tcaagcttca gcatgggctt gatacgtatg agcgtgagct gaaagaaatg 1548901 aaacgcctgt ataaacaaaa aacaacgctc ttaaaagacg aagaagtcaa acttggacga 1548961 atggaagtcg agcttgataa tttactccaa tacttacggg aggaatacag cttgtccttt 1549021 gagggggcaa aagagaaata tcagcttgaa actgatccag aggaagccag aaagcgcgtg 1549081 aagctgatta aactcgcaat tgaagagctg ggtaccgtga acctcggaag catagatgag 1549141 tttgagaggg tcaacgaacg gtacaagttt ctgtcggaac aaaaagaaga tttaacagaa 1549201 gcgaaaaata ccttgttcca agtgattgaa gaaatggatg aagaaatgac gaagcgcttt 1549261 aacgacacat tcgtccaaat ccgctcacac tttgatcaag ttttccgctc cttattcgga 1549321 ggagggcgag ctgaactgag gctcaccgat cctaacgatc tgcttcattc aggagtcgag 1549381 attatcgctc agccgccggg gaaaaagctg caaaacttaa acctcctgtc aggcggagag 1549441 cgtgcgctta ctgctatagc gctcttattc tcaatcctaa aggttcgtcc agtgccgttt 1549501 tgcgtccttg acgaagtaga ggctgcgctc gacgaagcga atgtgttccg atttgcgcag 1549561 tatttaaaaa aatacagcag cgatactcag tttattgtga ttacccacag aaaaggaacg 1549621 atggaggaag cggatgtgct ttatggcgta accatgcagg aatccggtgt ttccaaggta 1549681 atttcagtta agctggaaga aacaaaagaa ttcgttcagt aacgaggaaa gaggttaaaa 1549741 gatgagcttt tttaaaaaat taaaagagaa aatcacaaaa cagacagatt ccgtatctga 1549801 aaagtttaag gatggccttg aaaaaacaag aaactccttt caaaacaaag tgaatgatct 1549861 tgtatcccgt taccgtaaag tggatgagga tttcttcgaa gagcttgaag aggttcttat 1549921 cagcgcggat gtcggtttta caaccgttat ggaattaata gatgagctga aaaaagaagt 1549981 caaacgcaga aatattcaag atccaaagga agtccagtca gtgatttctg agaaactggt 1550041 cgagatttat aacagcggag atgagcaaat ttcagaactg aacatccagg atgggcgttt 1550101 aaacgtaatc cttctggtag gtgtaaacgg cgtcgggaaa acaacaacga tcggaaagct 1550161 tgctcataaa atgaaacaag aaggaaaatc tgttgtactt gccgccggag acacttttag 1550221 agcgggagcc attgaacagc tggaagtatg gggagagcgt acaggagtgc ctgtcattaa 1550281 gcagacggca ggaagcgatc cggcggctgt catctacgat gctgttcatg ctgcgaaagc 1550341 aagaaatgcc gatgtattaa tttgtgatac ggcagggcgt ctccaaaaca aagtaaatct 1550401 catgaaagag cttgaaaaag taaaacgtgt tatcgaaaga gaagttcctg aagctccgca 1550461 tgaggtgctg cttgcccttg atgccacgac cggccaaaat gcaatggctc aggcaaaaga 1550521 attctctaaa gcaacaaatg ttaccggcat tgctttaacg aagcttgacg gtacggcaaa 1550581 aggcggtatc gtccttgcga ttcgcaacga gcttcacatc ccggttaaac tagtcggttt 1550641 aggagaaaaa gttgatgacc ttcaggaatt tgatccagaa tcctatgtgt acggactctt 1550701 ttcagattta gtggaaaaag ccgacgatta agaaaaaggc cccaacatct tggggccttt 1550761 ttctttttta tcttcttact tgataggcga aatgataaag gctgttatca gtggatacca 1550821 gtcttgactc accagaaaaa actctgaatg ggatgatgtc atagtaatga acggaaacag 1550881 atgtgtaata cgtatagtaa ccagcagctg gccccaaata cattggaacc tcaaatgttc 1550941 cgtttgcatc agtcgttcct gaagcagttt gtgttgtgtt tccgaccttc gtgtccgctt 1551001 caaatcttac gggcgcgttt ggcactggct gtccgttttg gtcgagtaat ttgccgctta 1551061 ctgtaatatt gtacttgact cgccaatatt gaccttgtcc gtaattgatt ttaccgtata 1551121 cccctccatc tgtgctgata tttgtgattg aggccttata aggtgcctca gcagcgtctg 1551181 cttgctgtgc cgggaaacct attgtaaaca gggctgccag acataacata aacaataaac 1551241 cgattttttt cataaaaatc ctccttaaaa tagggttcat atacaatatc ggaataaatt 1551301 ggatgatatt tagcgtattt tggaaaagtt aatcgccgct ttgacaagat aaaaacttga 1551361 cagtgtcatt aaaaccgtgt aaactaagtt atcgtaaagg gatttgactt aacaaagggg 1551421 agagctcaaa tgtcactcga aaagacaacg agaatgaatt atctgtttga tttttatcag 1551481 tcgttgttga cgtcaaaaca gaagagctat atgtcgcttt attatttgga cgatttctcc 1551541 ctaggcgaaa tagccgaaga atatgaggtt tcaagacaag ctgtttatga taacatcaaa 1551601 cgaacagaag caatgcttga acaatatgaa gaaaagctgc tccttttgaa aaagtttcag 1551661 gagcgtaaag agatgtttaa taagctgaag gagcttgctt ccggttcaaa agaagaggaa 1551721 gaaattacag ctctgattga agcgcttgag aaattagatt aggaggcggc aaactatggc 1551781 atttgaagga ttagccgacc gactgcagca gacgatttct aaaatccgcg gaaaagggaa 1551841 agtcagcgaa caagatgtaa aagagatgat gcgtgaggtc cgtcttgcgc tgcttgaggc 1551901 tgacgttaac tttaaagtag tcaaggattt tgtcaaaaaa gtaagtgaac gcgctgtagg 1551961 ccaagacgtc atgaaaagtc tgacgcccgg ccagcaggtc attaaagttg ttcaagagga 1552021 actgactgag ctgatgggcg gcgaagagag caaaatcgcc gtcgcaaaaa ggccgccgac 1552081 tgttattatg atggtcggtc tccaaggtgc cggtaaaacg acaacaagcg gtaagcttgc 1552141 gaatctgctg cgcaaaaagc ataatcgcaa accgatgctg gttgctgccg atatttaccg 1552201 cccagccgca attaagcagc tggaaacact cggcaaacag cttgatatgc ctgttttctc 1552261 tcttggcgat caggtcagtc ctgtagaaat agctaaacag gctattgaga aagccaagga 1552321 agaacattat gactacgtca ttttggatac ggcagggcgc ttgcatatcg accatgaact 1552381 gatggatgaa ctgaccaacg tcaaagaaat cgcgaatccg gaagaaattt tcctggttgt 1552441 cgattcaatg accggtcagg acgctgtgaa tgttgccaaa agctttaatg aacagctcgg 1552501 tttaaccggt gttgtgttga ctaagctgga tggagacaca cgcggcgggg ctgcgctttc 1552561 tattcgcgct gtcacaaaca cgccaattaa gtttgcaggt ttgggcgaaa agcttgatgc 1552621 gttagagccg ttccatcctg aacgcatggc atcaaggatt ctcggcatgg gcgacgtgct 1552681 gacattgatt gaaaaagcac aggccagcgt tgatgaagac aaagccaaag agctggaaca 1552741 aaaaatgaga acgatgagct tcacattgga cgattttctg gagcagctcg ggcaagtcag 1552801 aaacatgggg ccgcttgatg agcttctgca aatgatgccg ggtgcaggta aaatgaaggg 1552861 cctgaaaaac atccaagttg atgaaaaaca gctgaatcat gtggaagcaa tcatcaaatc 1552921 aatgactgtt cttgaaaaag aacagccgga tattatcaat gccagccggc ggaagcggat 1552981 tgcaaaagga agcgggacat ccgtacagga agtcaaccgt ctgcttaagc agtttgatga 1553041 aatgaaaaaa atgatgaagc agatgacaaa catgtcaaaa ggcaagaaaa aagggtttaa 1553101 gctacctttt atgtaatcgg ttatacatga taaaaccgtt gttaagaaaa aacactttac 1553161 aaacactttt atcattgtta atatactatc ttgttgaaat attttcggag gtgctagtaa 1553221 aatggcagta aaaattcgtt taaaacgtat gggagcaaaa aaatctcctt tctatcgtat 1553281 tgttgtagca gattctcgtt caccacgtga cggccgtttc atcgaaacag tcggaactta 1553341 caacccggtt gcaaaaccag cggaagtaaa aattgacgaa gagcttgctc ttaaatggct 1553401 tcaaactgga gcgaaaccat ctgatacagt tcgcaacttg ttctctagcc aaggaatcat 1553461 ggaaaaattc cacaacgcta aacaaggcaa gtaatgactg atcaacactt ggaagatttg 1553521 attgtccaca ttgtgacgcc gcttgttgat catccagatg acattcgcgt cataagagaa 1553581 gaaaccgatc aaaagattgc gctgcgctta tctgtccata agtcagatac cggtaaagtt 1553641 atcggaaagc aaggccggac tgcaaaagcg attcgaacag ctgtatttgc agctggcgta 1553701 cagtcttcta agaaagttca atttgaaata tttgactaaa agggagaggg ccggcacctc 1553761 cccttttttt acacgcaaaa aaagggtaaa ctgatagaag cttaggcaaa atagaaaagc 1553821 ctggacgagt aaaagtttta aaagcgggga gcttggtgcg atgcaaatta ttcaccgtgt 1553881 agccgttatg caagtcttaa ccgagcgcag taaagaaaag cttttagctt cttttgctga 1553941 gaagaaacaa atgcttgaac gagaatgcag ccagctctat tttcagctta gaaaacatga 1554001 gaaagaacag caaaacccta atatgattga acaatttaaa aaggcaatag aaaagcgaaa 1554061 agatgatata aaaatcattg attttcaaat tgctcaagta catacattgc cgcttggcag 1554121 tgagttgaaa gaaaaggaag tcgatgcgct gctgacgatt gaagccgggg atgactggca 1554181 tgagaaaaca gcagcgaaca ccatcgtcat aaaagacgga aaagtaattg aaattcgcca 1554241 gaggtgatca tatgacaaag cgatggttta atgtaggcaa aatcgtaaat acccacggaa 1554301 tcaaaggcga agtgcgggtg atttcaaaaa cagattttgc cgaagaacga tacaagccgg 1554361 gaaacacgct gtatttgttt atggacggcc gtaacgaacc agtggaggta acggtaaaca 1554421 cacatagact gcataagcaa tttcatctcc tgcagtttaa agaaagacaa aacctaaatg 1554481 aagtagaaga gctgaaaaac gcaatcatta aagttcctga agaagaatta ggagagctga 1554541 atgagggtga attttatttc cacgaaatta ttgggtgtga agtatttact gaagaaggcg 1554601 aactcatcgg aaaggtcaaa gaaattttga cgcctggagc caatgacgtt tgggtcatcg 1554661 gacgaaaagg aaaaaaagac gcactcattc cttacattga atcagtggtt aaacatatcg 1554721 atgtcaggga aaagaaaatt gagattgaac tcatggaagg gttaatagac gaatgaaaat 1554781 cgattttttg acgctgtttc ccgaaatgtt tgaaggcgtg ctcggctcat cgattcttca 1554841 aaaagcccag gaaaaagatg cggtgcagtt tcaagtcgta aatttccgag agtactctga 1554901 taacaagcac aatactgttg atgattatcc ttatggcggc ggggcaggca tggttctcaa 1554961 gccccagcct gtttttgacg cggtcgagga cctgacatca aaggcagccg ctgctccgcg 1555021 tattatcctc gtatgcccgc aaggtgagcg ttttacccaa aaaaaagccg aacaattagc 1555081 taaggaagag catttgctgt tcatttgcgg ccactatgaa ggctatgatg aacgcattcg 1555141 cgagcacttg gtaacggatg aaatatcaat tggcgacttt gttctgacgg gcggtgagct 1555201 ccctgcaatg atgatcgcag acagtgtggt cagactgctt ccgggtgtac tgggtaaaga 1555261 ggcttcccat attgaggatt ccttcagcac cggactttta gagcacccgc attatacaag 1555321 accggcagat tacaaaggtt taaaagtgcc tgaaacactc ttgtcaggaa accatgcaaa 1555381 aattgaagaa tggcggaata aagaatcgat cagaaggacc tacctaagac gtccggatct 1555441 gttgaaagac cacccgctta cagagcagca aagaaagtgg atttctgaat gggaaaaaga 1555501 atagatttta ttgcataggc tatgaaattg tgataagata ctacttgtgg cttaagcggg 1555561 cttatccgct gcaagcttga aaacgatgtt ccgctgtgcc ggtttttgtg gccaagagca 1555621 tctgttggaa ggagttgaaa acgatgcaaa aactaattga agatatcaca aaagaacagc 1555681 ttcgtactga tcttcctgcg ttccgtcctg gtgacacttt acgtgtacac gttaaagttg 1555741 ttgagggtaa ccgtgagcgt atccagatct ttgaaggtgt tgtgattaag cgtcgtggtg 1555801 gtggaatcag cgaaacgttc acagttcgta agatttctta cggtgttggc gttgaacgta 1555861 ctttcccagt acacacacca aaaatcgcga aaatcgaagt tgtacgttac ggtaaagtac 1555921 gccgtgctaa actttactac ctgcgtgaac ttcgcggaaa agcggctcgt attaaagaga 1555981 tcagacgata atgataacga acgaaaagag cttgttacct gtaacaagct ctttttttat 1556041 acagaatttg aaaatgccgg acaggcatcg taaaatacat aaaggacaac aatgaatcat 1556101 gcatactgaa gataaaggcg gtgttcgtgt cacatgacaa ttcaatggtt cccgggccat 1556161 atggcaaaag caagaaggga agtaaccgaa aaattaaaat taatcgatat cgtatatgaa 1556221 ttggtagatg ccagaattcc aatgtcatca agaaacccaa tgattgaaga tattctaaaa 1556281 aacaagccgc gaattatgct gttaaacaag gctgacaaag cagatgcggc agttacacag 1556341 cagtggaaag agcactttga gaaccagggg atccgctctc tgtctattaa ttctgtaaat 1556401 ggacaagggt taaatcaaat tgtgcctgca tcaaaagaga tcctccaaga aaaatttgac 1556461 cggatgcgtg cgaaaggtgt gaagccgaga gcgattcgcg ctttgattat cggcattcca 1556521 aacgtcggaa aatcaacgct catcaaccgg cttgcaaaga aaaacatagc aaaaacggga 1556581 gacagacctg gtattacgac ttctcaacag tgggtcaaag ttgggaaaga attagagcta 1556641 ttagatacac cgggaatttt gtggcctaaa tttgaggatg agcttgtcgg tttgagactg 1556701 gcagtcaccg gggctattaa agactcgatt atcaatttgc aggacgtggc cgtgtttggt 1556761 cttcgttttc tcgaagaaca ttacccagaa cggcttaaag agcgttatgg ccttgatgag 1556821 atcccagagg acattgccga gctgtttgat gcaataggtg aaaagcgggg ctgtctcatg 1556881 agcggtgggc tcatcaacta cgataagacg actgaagtca tcattcgcga tattcgcact 1556941 gaaaagttcg gcaggctgtc atttgaacag ccgacgatgt aaaggcgcgc agaaatgcgg 1557001 gtctttattt tttcttggct gaaccgatac atacagtaag ggagaagaga aagtgaatac 1557061 attaaccgta aaggacatta aagaccgttt gcaggaagtg aaggatgcac aagacccatt 1557121 tattgcccaa tgcgaaaacg acccgagaaa aagcgttcaa acgcttgtag agcaatggct 1557181 taaaaagcaa gcgaaagaaa aagcgctgaa agaacaatgg gtgaatatga cttcctatga 1557241 aaggctggca agaaacaaag gatttcgctt gattgcaggt gttgacgagg tcggccgggg 1557301 gccattggca ggaccagttg tcgccagcgc agtcatcctt ccagaggaat gtgaaatact 1557361 tgggctgaca gactccaaaa agctttcaga gaaaaaacgc gaggaatatt acgagcttat 1557421 tatgaaggaa gcactggcgg tcgggatagg aattgtagaa gctactgtga ttgatgagat 1557481 caatatatat gaagcttcaa aaatggcaat ggtgaaagcg atacaggatt tgtcggatac 1557541 acctgattat ttgcttgttg acgcaatgac acttccgctc gacacggctc aggcgtcaat 1557601 tataaaaggc gatgccaaaa gcgtgtctat tgcggcaggt gcgtgtatcg caaaagtgac 1557661 gagggaccga atgatgagcg cttatgccga aacgtatccc atgtacggct ttgaaaaaaa 1557721 taaaggctat gggacaaaag aacatttgga agctctcgct gcatacggcc caactgaatt 1557781 gcaccgcaaa actttcgctc ctgttcaatc tttcagataa atcaccatgg acaaggaggc 1557841 acctttttaa aatgaacata cgaaatgatg tgcaaaaggc gctgcagcac cttttcgggc 1557901 gtacagccgt cccgcaggaa acatcaaaag taaacgaagc gctaaacggg gagaagcgtc 1557961 tcctcttagg aaaagtgctt cgtttactag gagatcagca tgccctgatc caagtcggca 1558021 atcaaactgt tcagggaaaa cttgaaactc agcttcgtcc tcaggcatac tattggtttt 1558081 cctacgaaaa aaaaacggca gagcaaacag gccgtcttca ggtcgttcaa agctttgatc 1558141 aaaatcctaa aaccattcag gatgcagctg gcaaactttt aaatgctatt tcagtgaaga 1558201 cgtcaaacgc agctctcatg atgacaggag cgatgctgaa aagcaaaaca cccgtaacag 1558261 aaaatgatat caaaacagct gtccgctgga tggacacgct gccttcgcaa gacacaaaaa 1558321 aagcagttga aacggttctc ttcgctttaa agcgtgatct tcccattcac tccgagattt 1558381 tgaatggtgt tcacgctgtg aaatcgcctg ttccgttgca tcagcacgta tcccagctgc 1558441 tacaggcaat cgaccaaaac cctcagcaga gccaaatgat gtcaaagcta aaggaagcag 1558501 tcacggtgct tttaaatagt gaaatcgatg tccatgcaga acggctgatt gataagctta 1558561 tttctttaac cgacaatacg aaagcacctt ctccgacgaa tacagctgga agcagggagc 1558621 ttagcacacc agctggctcc cccggaaaag ccagcctgcc gattgcaaat cacacagcag 1558681 aacagggaag catacaagaa gagcctgtta aaacagcagc agacattcca attaaagaag 1558741 cccgccagct gctggtgaag ctgacggaat ctgctgaaaa aaacagtctc caaattgtga 1558801 aagaagcagc aaattggatt aaagcggctg cttcatcggg tgatagtaag tcacttgcag 1558861 cttcagctgt tttacaggcg gcacaagtca cagatcagga agccgaagtc tttttaaagg 1558921 ctgttcagca gacagcaccc catttggcgg ataaggcaga tgttctttct ttcttatcca 1558981 aagtgaaaac ggcaatcggc gcaagggacg aggttgcgtt cattaaagcg tttgaacaag 1559041 gaagcgcagt cacatctggc gaaatgcaat ccatcaagct ggctctttct gccttaagag 1559101 catcgcatga ggtagccgaa ccagtcaaac aagaagccga tcagcttttt cataaattaa 1559161 atggccagct tttcatgcag caggaccatc catcatacag ccaaattgta atgtcatttc 1559221 cgatgttttc gaagtcaggg gttcaggaca tgactgttct gtttaaagga aagaaagaag 1559281 cggatggaaa gcttgatcct tcccattgcc gccttttgtt tttgctgcag cttgatacac 1559341 taaaagaaac cgtcgttgat tgcttggtac agcaaaaagt catgaccatt acaatagaga 1559401 ctgatttcga gctgcaggct gcgatcgatc cgatggtgcc cgcgcttaaa caggggctaa 1559461 aggaaatggg gtacagcctt tcaggggtaa acgctaaaaa aagggttcac accgaagaaa 1559521 aggcttcaat cgatcaatat ataacaagta tcagtgatca ggaagtggat gtgaaaatat 1559581 gaaagagcag acaccgatca gaaaagctgt tgctctccat tatgacgaac aaaaagacaa 1559641 ggcgccgaga gtgattgcca cagggaaggg ccatgtagct gacaacatta taaaagaagc 1559701 gaaaaaagca ggggtcccga ttcaagaaga tcggaccctt gtcgaattaa tgcgccattt 1559761 gacggtagat gatcaaattc ctgaagctct ttatgaaacg gtagccgaga ttttttcatt 1559821 catttacaaa ttggacgaaa gcgtaaaaaa caaaaaatag ctaaaatatt ccccatcctt 1559881 ctttgaaatt tatgttttta ataaagtaaa agtttgaatg tttagaagga ttaaaagatt 1559941 ttgcatcgaa ctgtagacaa ttcttccagt attattatag aatgaaagcg cagtctattt 1560001 tagttttgtt acataagtta ggaggatggg aaatgaatat ccatgagtac cagggaaaag 1560061 aagtcctcag aaaatatggg gtatctgttc ctgaaggtaa agtggctttt acagcagaag 1560121 aagcagttga gagtgcaaag agcttatcca gctcggttta tgtcgtaaag gctcaaattc 1560181 atgctggcgg tcgaggcaaa gctggtgggg taaaaatagc aaaatcatta gacgaagtaa 1560241 aagcgtatgc cgaagaacta ttagggaaga ccctagttac acatcagacg ggtccggacg 1560301 gccaagtaat aaaacgctta cttattgaag aaggctgcga tattaaaaaa gaatattaca 1560361 tcggtctagt gcttgaccgc gccacttcaa gaatcgtttt aatggcttct gaagaaggcg 1560421 gaacggaaat tgaagaggtt gcggagaaaa caccagaaaa aatcaaaaaa gctgtcattg 1560481 atccagctgt tggccttcaa ggctatcaag ccagagaaat tgcattcgct attaatattc 1560541 caaaagagct cgtgggaaaa gctgctaaat ttatgcttgg actatataaa gcgtttgttg 1560601 agaaagactg ctcaatcgcc gaaatcaatc cgcttgttgt gactggcgac ggaaatgtga 1560661 tggcgcttga tgcaaaattg aattttgaca gcaatgcgtt gtaccgacaa aaggacatta 1560721 tggaatacag agatttggat gaagaagatc cgaaagaaat tgaagcgtcc aaatatgatc 1560781 taagctacat ttcccttgat ggaaatatcg gctgtatggt aaacggcgcg ggacttgcaa 1560841 tgtctacgat ggatattatc aagcattatg gaggagaacc ggccaacttc cttgatgtgg 1560901 gcggcggtgc aaccgcggaa aaagtcacgg aagcatttaa aatcattctt tctgatcaaa 1560961 acgttaaagg gatttttgtc aacattttcg gcggcattat gaaatgtgat gtcatcgcag 1561021 aaggggttgt tgaagcgact agacaagttg gtttgacatt gccgcttgtc gtccgtcttg 1561081 aaggcacaaa cgtggatcta gggaagaaaa tccttagtga atcaggatta aacattacat 1561141 ctgcggaatc aatggctgac ggcgcgcaga aaatcgtatc cttagtttaa gaaagaatga 1561201 aaggcagggg accaaataat gagtgttttc attaataaag atacaagagt tattgtgcaa 1561261 gggattacag gttctaccgc tttatttcat acgaagcaga tgcttgaata cggcacaaat 1561321 atcgttggcg gtgtaacacc tggaaaaggc ggaacagaag cggaaggtgt tcctgtattt 1561381 aatacagtgg ctgaagcagt tcaaacaacc ggcgctaacg cgtctgttat atatgtgccc 1561441 gcaccgtttg cagctgatgc gattatggaa gcggtagatg cggagcttga tctcgtgatt 1561501 tgtatcacag aacatatccc ggttttggat atggtgaagg tcaaacgctt catggaaggc 1561561 aagaaaacga gactgatagg gccgaactgt cctggtgtca ttacgcctga agaatgtaaa 1561621 atcggcatta tgcccggata catccataaa aagggtcatg taggcgttgt atcacgttca 1561681 ggaacattaa catacgaagc ggtgcaccag ctctcagaag cgggtgtagg gcaatctaca 1561741 gctgttggaa tcggcggcga ccctgtaaat ggaacaaact ttattgacgt tttaaaagcg 1561801 tttaacgaag atcctgacac acacgcagtc atcatgattg gcgaaatcgg cggtacggcc 1561861 gaagaggaag cggcagagtg ggtaaaagcc aacatgacaa aaccggtagt cggttttatt 1561921 ggcggtaaaa cagcacctcc tgggaagcgc atggggcatg caggcgccat tatttccggc 1561981 gggaaaggga cagctgatga aaaaatcaaa acccttaatg catgcggaat cgaagttgca 1562041 gagacacctt ctgtcatggg tgaaacctta atcaaggtgc tgaaagagaa gaacttgttc 1562101 gaaacttgta aaacgcatta ataaaaaagg gacagccgtc aaggctgttc ctgctttttc 1562161 taacaaaagg aggtcaatct attggatcag gccgctgtct gcctaacgat ttgcagaatc 1562221 aatcaattat tatccccatc ccttctatta aaatggtgga aagccgatcc gtctatgtcg 1562281 ctgacatcac ccgtgttaca aacggttact cgtgatcaaa taaaagcagc tgcattaaaa 1562341 aacgaaatag aacaatttta tccaaagctc ccgcgtgtac ttgctgctta tcgtgagcaa 1562401 ggcattaaca ccatccctat ttcttcaaag caatatcctt tctggcttaa aagcatttat 1562461 gatccccctg ccgtactgtt tgcaaaaggt gatatgactc ttctttcgaa agggagaaaa 1562521 attggaattg taggcacaag aaatccaaca gcttatggga aacaagttgt caatcatctt 1562581 acaaaagaga tctgtcgtaa aggttgggtg attgtcagcg gactggcgtc tgggatagac 1562641 ggaatgtccc atgctgcaag tattaaggcg aaggggcgga caattggcgt cattgcaggc 1562701 ggatttcaac acatttatcc ccgagaaaac cttcagttag cagatcacat ggctaaacac 1562761 catatcctgc tgtcagagca cccacctgaa actaaacccc aaaaatggca tttccctatg 1562821 agaaaccgta ttatcagcgg actaagtgaa ggcgttattg tcgttcaggg caaagaaaaa 1562881 agcggttcgc tgattactgc ctatcaagca ttggaacaag ggagagaggt atttgccgta 1562941 cccggttcat tgtttgaccc ttacgccgga ggtcctataa aactgatcca gcagggggct 1563001 aaagccatat ggtcagcaga ggatattttc gaggaacttc ctgagagaaa cgttcaatat 1563061 acggaaccct tttgaattat cgtttgacaa acggtattgt aatatttaat aatagtgagg 1563121 atttaaagtt gcatattgtt ttctatttaa ttaatgacgt tcatgataaa gaatgaaatg 1563181 ttgaaagcca aataaagaca gctgcaaaaa taaaattgaa atatcttgaa aagagagaga 1563241 acacctcttg agggggatga aaatgtctga ttatctagtc atcgtggaat cgcccgctaa 1563301 ggcgaaaacg attgaacgtt acttaggtaa aaaatataaa gtaaaagcat caatgggaca 1563361 tgtccgggat cttccaaaaa gtcaaatggg agttgacata gaacagaatt ttgaaccgaa 1563421 atatattacc attcgaggta aaggcccggt attaaaagag ctgaaaacgg ctgcgaaaaa 1563481 agccaaaaaa gtgtatctcg cagctgaccc cgacagagaa ggggaagcga ttgcatggca 1563541 tttggcacac agtcttgatt tagatctcaa ctcagactgc cgtgtggtgt ttaacgaaat 1563601 tacaaaagac gctattaagg aatcgtttaa gcatccccgc atgatcaata tggatttagt 1563661 ggatgcacag caagcgagac gtattttaga caggcttgtc ggatataaaa tcagtccaat 1563721 cttatggaaa aaagtcaaaa aagggcttag cgcaggacgc gtgcaatccg ttgccctccg 1563781 tttgattatt gaccgtgaaa aagagattaa cgactttaag cctgaggaat attggacaat 1563841 tgacggtacg ttcttaaaag gtcaagaaac ctttgaagcg agctttttcg ggaaaaacgg 1563901 caaaaaactt cctttaaata gtgaagctga tgtaaaagag attctttctc agctcaaagg 1563961 gaatcaatat acagttgaaa aagtaaccaa aaaggaacgc aaacgtaatc ctgctttgcc 1564021 ttttaccact tctaccctgc agcaggaagc ggctcgcaag ctcaatttca gagcgaagaa 1564081 aacgatgatg attgcacagc aattatatga aggaattgat ttaggaagag aaggaacggt 1564141 tggtctgatc acgtatatga gaacggattc aacccgtatt tcaaatacgg ctgttgatga 1564201 agcagctgca tttattgatc agacatatgg aaaagagttc ctaggcggaa aacggaagcc 1564261 tgcgaaaaag aatgaaaatg cccaggatgc ccacgaagca attcggccga catcagttct 1564321 tagaaaacca agtgaattaa aagcagtcct cggcagagac caaatgagac tgtataaatt 1564381 aatttgggag cgttttgttg ccagccaaat ggcaccggct gttctcgata caatgagtgt 1564441 cgacctgaca aacaacggtt tgacatttcg tgcaaatgga agtaaagtca agttttccgg 1564501 gtttatgaag gtgtatgttg aaggaaaaga cgatcaaatg gaagaaaaag accggatgct 1564561 gcctgactta caagaaggcg acacggtatt atcaaaagat atagaacctg agcagcattt 1564621 tacccagccg cctccgcgat atactgaggc ccggcttgtt aaaacccttg aagaacgcgg 1564681 tatcggccgt ccatccacat atgctccgac acttgatact attcagcggc gcggctacgt 1564741 ggcattggat aataaacgtt tcgttccgac tgaattaggt cagatcgttc ttgacttgat 1564801 catggagttt ttccctgaga tcattaacgt tgagtttaca gctaaaatgg agagagatct 1564861 tgatcatgtt gaagaaggaa ataccgaatg ggtcaagatt atcgataatt tctacaccga 1564921 ttttgaaaaa cgcgtcaaaa aagccgaatc ggaaatgaag gaagttgaga ttgaaccaga 1564981 gtatgctgga gaggattgtg aattgtgcag ttctccaatg gtatataaaa tgggacggta 1565041 cggtaaattc ttagcttgct ccaacttccc tgactgccgg aacacgaaac cgattgtgaa 1565101 acaaatcggt gtgaagtgcc cgagctgcgg agaaggaaac attgttgagc gaaaatcgaa 1565161 aaagaaacgg gtgttttacg gctgtgaccg ttatccggac tgtgaattcg tatcatggga 1565221 caaaccaatt gaacgaaaat gcccgaaatg cggaaaaatg ctcgtcgaga aaaaactcaa 1565281 aaaaggtata caagtccaat gcgtggaatg cgattataag gaagaaccac agaagtagcg 1565341 gtgagcaggg tcttgctcac cttctttgtg tgttaaaaga aggccttgaa taataaacta 1565401 ggagatgtga aagatgaacc aacaaacagt gaatgtaatc ggagccggac tcgcaggaag 1565461 tgaagcagca tggcagcttg ccaaacgtgg gattcaagtc aaattgtatg aaatgcggcc 1565521 agttaaacaa acgcctgcgc atcatacaga taaatttgct gagcttgtct gcagcaactc 1565581 tcttcgctct aatacacttg ctaacgctgt cggtgtatta aaggaagaaa tgcgtgcgct 1565641 tgattcagcc attatcgctg cggctgacga atgttcggtg cctgccgggg gcgctcttgc 1565701 agtagaccgt catgaatttg ccgcaagtgt gacaaatcgg gtgaaaaatc atccaaacgt 1565761 aaccgttatt aatgaagaag tgactgaaat tcctgaaggc cctactatca tcgcaacggg 1565821 tccgttaaca tctgaatcgc tgtctgccca gctgaaggag ctgactggag aggactattt 1565881 atatttttat gacgcagcgg cgccaattgt agaaaaagac agccttgata tggataaagt 1565941 gtacctgaaa tcccgttatg ataaaggtga agcagcatat ttgaactgcc cgatgacaga 1566001 agaagagttt gaccgttttc atgaagcatt aacatcagca gaaacagtgc cgttaaaaga 1566061 atttgaaaaa gagattttct ttgaaggctg catgccgatt gaagtcatgg caaaacgggg 1566121 taagaaaaca atgcttttcg gtccgatgaa accagttggt ctagagcatc ctgttacagg 1566181 aaaacgccct tatgccgtcg ttcagctcag acaggatgat gctgcgggaa cactttataa 1566241 tattgtagga ttccagacac atttaaaatg gggagaccaa aaggaagttc tcaagttgat 1566301 tccaggactt gaaaatgtag aaatcgtcag atatggcgtg atgcatagaa acacatttat 1566361 taactctcca agcctgttaa agccgactta tcaatttaaa aaccgcagtg atctgttctt 1566421 tgcaggccaa atgacgggag tagaaggata tgtggaatca gctgcctcag gacttgtagc 1566481 aggcattaat gcggcgaagc ttgtattggg agaagagctt gtgatcttcc ctcaggaaac 1566541 agcaattggc agtatggcac attatattac aacaacaaac cagaagaact tccagccgat 1566601 gaatgcaaac tttgggcttt tgaaagaatt gccagttaaa attaaaaata aaaaagaacg 1566661 aaatgaacaa tacgcgaacc gtgcgattga aacaattcaa acaatttcga aaacaatata 1566721 ggtattgatt gcaacctgag cgcgatttgt gataccattt aaaagccctt cctggggagg 1566781 tattaggcat ggagaatgtt aagaatttcg taaagttatt cgttgaatat ttacaaattg 1566841 aaaaaaatta ttcacaatat actattgtga attatgtgga ttcaattgaa gaattcgaga 1566901 ctttcctgcg cgttcaaggt ataaatggat ttgaagaagc tgcatatcaa gatactagga 1566961 tttttttgac agaagcctat gaaaaaggtt tatcgagaag aacaataagc aaaaagatat 1567021 ctgcattaag aagcttttat aagtttctga tgcgggaaaa gcttattgaa gaaaatccgt 1567081 ttcagcttgt tcatctgcca aaacaggaga aacggatacc gaagtttcta tatcaaaaag 1567141 agcttgagga gctgtttgaa gtttcagata taagccagcc ggccggaatg agggatcaag 1567201 cgctgttaga gctgctctat gccactggaa tgagggtcag tgaatgctgt tccataacta 1567261 ttaacgacgt tgatttattt atggacactg tgcttgttca cggtaaaggc aagaagcagc 1567321 gctatatccc ctttgggtct tatgcccgcg aagcgttgaa ggtatacatg aatagcggaa 1567381 gacagtgctt gctgatgaag gcaaaagaac ctcatgatct attattcgta aatcaaagag 1567441 gcggaccgct tacagcccgt ggcatcagac atattttaag cgggcttgtt caaaaagcgt 1567501 caagcacttt acatatccat ccgcatatgc ttcgacatac gttcgccacg catctgttaa 1567561 atgaaggagc ggatttgaga agcgttcaag aactgctcgg gcattccaat ctgtcttcta 1567621 cacagatata cacgcacgtt tcgaaggaaa tgttgagaaa cacatatatg tctcaccatc 1567681 caagagcatt taagaaaaat taaaggaggc cctttatgtc atcttttcat gcgaccacaa 1567741 tatttgccgt acagcataaa ggacgaagcg ctatgtccgg agacggccaa gtaacatttg 1567801 gtcaggctgt tgtcatgaaa cacacggcac ggaaagtgag aaaactgttt aacggcaaag 1567861 ttcttgctgg ttttgcggga tctgttgcag acgctttcac tttattcgaa aagtttgaag 1567921 ctaagcttga agaatataac ggcaacttaa aacgggcggc tgttgagctt gcaaaggaat 1567981 ggcgcagtga taaagtgcta agaaagctcg aagccatgct gattgttatg aatcaggata 1568041 ctttgcttct cgtatcggga acaggcgagg tgatcgaacc agatgacggc attctcgcga 1568101 ttggatcagg aggcaattac gctttggcag cgggaagagc actgaaaaag catgccgggg 1568161 aaagcatgtc tgcaagtgag attgccagag ccgcgttaga aacagcaggc gaaatttgtg 1568221 tttacacgaa cgatcaaatc atactggaag agcttgaata gaaaggactt gaggcgcatg 1568281 gaaaaaaaac cgttaactcc tagacagatt gtagatcggt tagaccaata tattgtcggt 1568341 cagcaaaatg cgaaaaaagc tgtcgccgtg gcattaagaa accgctatag aagaagtctt 1568401 ctggatgaaa agctgaagga cgaggtcgtt ccgaaaaaca ttttaatgat gggtcctacc 1568461 ggcgtcggga aaactgaaat tgccagacga atcgctaagc tttcaggtgc gccatttatc 1568521 aaaattgaag ctactaaatt taccgaagtc ggctatgtag gcagagatgt tgaatcaatg 1568581 gtcagagatc ttgtggagac ttctgttcgg cttataaaag aagagaaaat gaatgaagta 1568641 aaggaacagg cagaagaaaa tgcaaacaaa cgcattgttc gtctgttagt tcctgggaag 1568701 aaaaaacaat ctggtgttaa aaatccgttt gaaatgtttt ttggaggcag ccagccgaat 1568761 ggtgaagatg aggcggagag ccaggaagaa gcaaacatcg aagaaaaaag aaaacgaatg 1568821 gcgcatcagc tggctttagg agagctcgaa gactactatg taacagtaga agtcgaagaa 1568881 cagcagcctt ctatgtttga catgctgcag ggctcgggta tggagcagat gggtatgaac 1568941 atgcaggatg cgctgagcgg attaatgcca aagaaaaaga agcggcgcaa aatgacagtc 1569001 agagaagcca gaaaagtcct gacgaatgaa gaagcaagca aactcatcga tatggatgaa 1569061 gtcggccagg aagctgttca gagagcagaa gagagcggga ttatctttat cgatgagatt 1569121 gataaaatcg caaagaacgg cggtgcatct tcttctgccg atgtttcaag agaaggtgtt 1569181 cagcgggata tccttccgat tgttgaaggt tctaccgttg tcacaaaata tggttctgta 1569241 aaaacagacc atgtattatt tattgcagca ggagcgtttc atatggccaa accgtctgat 1569301 ttgattcctg agctgcaggg gcgtttcccg attcgtgtag aactgaacaa actcacggta 1569361 gacgacttcg tgagaatttt ggttgagccg gataatgcgc tgctgaaaca atatcaggca 1569421 ttattgcaga cagaaggtat atctcttgaa ttttctgacg aagctattca taagattgct 1569481 gaagttgctt atcatgtgaa ccaggacaca gataatatcg gtgcgagacg ccttcataca 1569541 atacttgaac gcctattaga agatttgtcg tttgaagctc cagatgtaac gatggagaaa 1569601 ataacgatta caccacagta tgtcgaagaa aagctcggaa cgatagccaa aaacaaagat 1569661 ttaagtcaat ttatattgtg aaaaatttaa tatgaggaat gtttaggagg attatttatc 1569721 atggctttat tacaaaaaac aagaattatt aactccatgc tgcaagctgc ggcagggaaa 1569781 ccggtaaact tcaaggaaat ggcggagacg ctgcgggatg taattgattc caatattttc 1569841 gttgtaagcc gcagagggaa actccttggg tattcaatta accagcaaat tgaaaatgat 1569901 cgtatgaaaa aaatgcttga ggatcgtcaa ttccctgaag aatatacgaa aaatctgttt 1569961 aatgtccctg aaacatcttc taacttggat attaatagtg aatatactgc tttccctgtt 1570021 gagaacagag acctgtttca agctggttta acaacaattg tgccgatcat cggaggcggg 1570081 gaaagattag gaacacttat tctttcgcgt ttacaagatc aattcaatga cgatgactta 1570141 attctagctg aatacggcgc aacagttgtc ggaatggaaa tcctaagaga aaaagcagaa 1570201 gaaattgaag aggaagcaag aagcaaagct gtcgtacaaa tggctatcag ctcgctttct 1570261 tacagtgagc ttgaagcaat tgagcacatt tttgaggagc ttgacggaaa tgaaggtctt 1570321 cttgttgcaa gtaaaattgc tgaccgtgtc ggcattaccc gttctgttat tgtgaacgca 1570381 ctcagaaagc tggagagcgc cggtgttatc gagtctagat cattaggaat gaaaggtact 1570441 tatatcaagg tactaaacaa caaattccta attgaattag aaaatctaaa atctcattaa 1570501 tcacaaaaag aacccttttt gagggttctt tttttatttc aaataaagga aatcaataag 1570561 ctttatttcc tgggttgaaa gtctttctat gtaataattt taataaattt tgcatttttc 1570621 ttcaaaaagt ttcaaaaatg ccgaaaagaa aggagaaaaa acagaaattc tgctattttc 1570681 aggcttatat caaggcgaga aatgtagttc taacaatcta ggactttata cctagttgca 1570741 aaatagataa ttgtgaggac atttttttac acgaacttca tagactttat gcctgttatt 1570801 tcttacaata agcatatagt tttacaattc tcgacaagga tattgagggt gaaaaaaact 1570861 gaaatggagg taagtggatt tgagcttatt ttctggaacg atacaaaatc ttgaaaatgc 1570921 cttgagcaga gcggatatta agcaaaaagt cataactaat aatatcgcca atatagatac 1570981 accgaactat aaggcaaaaa aagtctcttt ccaaaattta ttagatcaag aatcctcgcg 1571041 tcttgaagcg ataaaaacag actatcgtca tgttgatttt tctgatactg attcgaatta 1571101 ttcaattgtt gcgagcggag atacatcgta tcagcaaaac ggaaacaatg ttgatgttga 1571161 caaagagatg acagaattgg cgcaaaatca aatcaactat caagctttgg ttgaaagaat 1571221 gaacggtaaa tttaattcgc tgaagaccgt attaacagga ggaaaatgat gacagctttt 1571281 catagcttaa atgtttcagc atcggcttta acagctcagc gagtcagaat ggacgttgta 1571341 tcatctaact tagcaaatat ggatacgaca agagctaagc aggtgaatgg agagtgggtg 1571401 ccttacagaa gaaaaatggt ttcccttcag tcaaaaggtg aatcgttctc ttccattctc 1571461 aattctcaaa tgagcggaag cgggaatgct ggaaacggtg tgaaggtttc aaaaattacg 1571521 gaggatgatt cggattttaa tcttgtctat gatccgacag accctgatgc aaacgctgaa 1571581 ggatatgtac aaaagcctaa tgttgatcca ttaaaggaaa tggttgatct tgtcagcagc 1571641 actagatcat acgaggcgaa tgtcacggcg atgaatgcca caaagggaat gctgatgaag 1571701 gcgttagaaa tcggaaagta ggtgaatgaa tgtgattaat gcaatttctc cttttcaggt 1571761 tcaaaatact caaaacactc aaaatgcaac aaatcaagta aacaatagcc aaaaaacaga 1571821 ttcttcaaat caaacaagct tttcggagct tttaaaaaac tctattagtt cgttaaatga 1571881 gtcccaagta gcttctgaca acatgactaa tgccttggct gcaggaaaag atgtaaatct 1571941 tgatgaggtc atgatcgctg ctcaaaaagc tagcatctct ctaactgcag caacagagtt 1572001 ccgcaataaa gctgtggaag cttatcagga gattatgaga atgcaaatgt agggggtctg 1572061 acgatttaga gaaagagtgg aatgaccggg ggttaacatg aatcgtactc taatgcaaat 1572121 gaaaaacaaa acgagtgagt tttggaaaaa tagatctaaa ttacaaaaga ttttaatggt 1572181 tagtgcttta gcggcaatta ttattattgg aattattatt agtgtttttg cttcaaattc 1572241 taaaatggcg ccgctgtaca aagatttgtc tgccgaagaa gcaggacaaa tcaaagaaga 1572301 attggatgca aaaaaagtgc caaacgaact ttcgaatggc ggtacagtga ttagtgttcc 1572361 ggaggatcag gttgattctt tgaaagtgca gatggctgca gaaggacttc ctaaaacggg 1572421 atcaattgat tattcgtttt ttggacagaa tgccggcttt ggtttgacag acaatgagtt 1572481 tgatatggtg aaagtgaaag ctacacagac agaactgtca aacttgatca atgaaatgga 1572541 cggtattaaa aattcaaaag taatgattaa tctcccgaaa gacgctgtgt ttgtcggtga 1572601 agagcaatct gcagcatctg catcaatcgt tttgcagatt caaccgggtt atacacttga 1572661 tcaaagccaa atcaacggat tatatcatct ggtatctaaa agcgtgccaa acctaaaaga 1572721 agataacatc gtcatcatgg accaaaattc tacatactac gacaaatcag acagcgatgc 1572781 agggtcctac gcggatagtt attcttctca gcaaggaatt aagtctcaag ttgaaaaaga 1572841 cattcaaaaa catgtacagt cactgctggg tacgatgatg ggccaagata aagtcgttgt 1572901 ctccgttaca gcagacattg atttcacaaa agaaaatcgg acagaagaca ttgtcgaacc 1572961 tgtggataaa gaaaacatgg aaggcattgc agtcagcgct gaaaaggtat ctgaaacata 1573021 tcagggcgac ggtgcagcca acggcggaac tgccggaacc ggcgaggaag atgttacaaa 1573081 ttataaggct gacggtgaaa ataccgaaag cgggaactac gaaaaaaaca gcaacaaaat 1573141 caattacgag gttaaccgaa ttcataaaga aatcgctgaa agtccttata aggtcagaga 1573201 tttagggatt caagtaatgg tagagccgcc tgatgccaaa aacactgcgt cgctatcaac 1573261 tgaaagacag gatgatatac aaaaaatcct ttcaactgta gtcagaacat ctttggataa 1573321 agatgaaacg caaaatcaga atttatctga tgctgatatc aataataaga ttgttgtttc 1573381 cgttcagcca ttcgacggaa aagtcaattt ggatacaaat acggaagaat cctcaggtat 1573441 cccgctgtgg gcatatattg taggcggtgt tttaatcgca gcgatcattg ttctgatcat 1573501 tatgcttatc agaaagaaac gggcgcaaga ggatgaattt gaggaatatg agtatgaggt 1573561 tcctcaagaa ccaatcaatt tgcctgatat caacgaagag gaaaatgaaa cagcggaatc 1573621 agtcagacga aaacagcttg aaaagatggc gaaagacaag ccggaagatt ttgcaaaact 1573681 gctgagaagc tggctggccg aggattagga ggaattagaa atggcgagac gtgatcaaga 1573741 taagcttaca ggaaaacaaa aagcagccat tctcatgatt tccttggggt tagatgtgtc 1573801 agcttctgtc tataagcact taaccgatga agaaattgaa aggcttactc tggaaatatc 1573861 aggtgttcga agcgtcgatc atcaaaaaaa ggatgaaatc atagaagaat ttcataatat 1573921 agccattgcg caagattata tttctcaagg cggtttaagc tatgcaagac aagttctgga 1573981 aaaggcgctt ggagaggata aggcggagaa cattctaaac aggctgactt cttctttgca 1574041 ggttaaacca tttgattttg ccagaaaagc ggagccagaa caaattttga attttatcca 1574101 gcaagagcat ccgcagacga tggcgttaat cttgtcttat ttagatccag tgcaggccgg 1574161 gcaaatttta tccgagctga accctgaagt gcaggctgag gttgcgagaa gaatcgcggt 1574221 catggataga acgtctccag aaataattaa cgaggtagaa cggattctgg aacaaaaatt 1574281 atcttctgca tttactcagg attatacaca aacaggcgga attgaagctg ttgtggaagt 1574341 gttaaacggg gtagacagag ggacagagaa gacgatcttg gattcattgg aaattcagga 1574401 tcccgatctt gctgaagaga ttaaaaagcg gatgtttgtc ttcgaagata ttgtcacact 1574461 tgataaccgt gcaattcaga gagtcattcg cgatgttgag aacgacgatt tgctcctttc 1574521 attaaaggtt gcaagcgagg aagtcaaaga aattgtgttc aacaatatgt cacagcgtat 1574581 ggttgaaacc ttcaaagaag aaatggagtt tatgggccct gtacgtttga aagatgtaga 1574641 agaagctcaa tcaagaattg taagcatcgt cagaaagctt gaagaagccg gtgaaattgt 1574701 aatagcaaga ggcggagggg atgatattat tgtctaatat cattaaacaa gaatcatcta 1574761 tttctccaca aaaggaaaaa agaaaacttt ctatacaaga ggtgcgtatt gatcattctc 1574821 accttttgca ggctgaagag aacccggagg cgcttatggc ccgagtgaaa gaggaagctg 1574881 accggatttc tgagcaggca aacagtcata tagaaaatat tcgccgtcaa attgaacagg 1574941 agaaaaacga ttgggcggct gaaaaacaga agcttattga agaagcaaaa gccgagggct 1575001 ttgaacaagg agtagcgctg ggcaaagctg aggcaatgaa acagtatgca gaactgatcg 1575061 gccaagcaaa cagtataact gaaatgtcca gaaaagctgt tgaggacaag cttgaagacg 1575121 ctaatgaaga aatcgttgag cttgccgttg ccctagcaaa aaaagtttgg cagcaaaagt 1575181 ctgatgataa agaggctttc ctcctgcttg tacaacaggt tataaacgaa gtgaaggaat 1575241 atgacgatat atcaatttat gttgatccat attactatga gacaatcttt cagcaaaaag 1575301 atgaaatcca gcagcttctt tataaagaat gtcggcttgg catatatgct gatgaaaaag 1575361 ctcaaaaagg aacctgttat attgaaactc cttttggcag ggtagatgcg agtgttgaca 1575421 cacaattgat gcaattgaaa gataaacttc tgacagcgct ggaagcaggt gcagctgaat 1575481 gaagacacag agtctgatag attgtataga aatgacagac tcgtataaac ggtacggaaa 1575541 agtcaagcgg gtaatcggct tgatgattga atcaaaaggg ccagcaagct caattggtga 1575601 cctgtgcctg atttatgcaa aaggacagtc tgggaaagtc attaaagctg aggtagtcgg 1575661 cttccaggaa gaaaatattt tgcttatgcc ttatttagag gctgcgagca ttgcacctgg 1575721 cagcattgta gaagctactg gggaatcact tcgggttaaa gttgggaccg gactgatcgg 1575781 acaagtcatc gatgcttttg gagaaccgct tgacggaaag cttctgccga aagggctttc 1575841 gcctgtatca acggagcaat caccgcctaa cccgatgaaa cggccgccta tccgtgaaaa 1575901 gatgggtgtt ggagtcagat caattgacag cttgctgaca gtcggtaaag gccagcggat 1575961 tggaattttt gcaggaagcg gtgtcggaaa aagcacctta atggggatga tcgccaagca 1576021 gacagaggct gacttaaacg tcattgcact tgtcggagaa cgcggacgag aggttcggga 1576081 gtttattgaa aaagatctgg ggaaagaggg gctgaaacga tcgattgtag tcgttgccac 1576141 ctcagaccag ccagcattaa tgagattgaa agcggcatat acagcgactg caattgccga 1576201 gtatttccga gataaaggcc aaaatgtcat gtttatgatg gattctgtta caagggtggc 1576261 aatggcgcag cgagagattg gactggctgc aggagagcct ccgacgacaa aaggctatac 1576321 accttcagtg ttcgctattt tacctcgttt actagaacga acaggtgcaa acgagcatgg 1576381 aaccattacg gcattttata cagtgttggt agatggggat gacatgaatg agccgattgc 1576441 cgataccgta cgcggaattt tagacgggca tattgtgttg gacagggcgc ttgccaataa 1576501 aggccagttt cctgcagtta acgtactaaa aagcatcagc agggtgatgt caaacatttc 1576561 aacaaaacag catctggatg cggcaaataa attccgtgaa cttttatcga catatcaaaa 1576621 ttcggaagat ctcattaata tcggagctta caaaagagga tcatccagag aaattgatga 1576681 agcgatacaa ttttatccgc agcttattca atttttaaag cagggaacag acgaaccggc 1576741 tttattggaa gaaagcattg ctgcattaac tagtttgaca ggaaatgagg aataaacgtg 1576801 gcttatcaat ttagattcca aaagctgctg gaactaaaag aaaatgaaaa agaccaatcc 1576861 ttatccgaat atcagcaatc agtttctgaa tttgaaaacg ttgctgaaaa attatatgag 1576921 aatatgagca aaaaggaatt gctggaacaa aataaggaaa agaaattaaa aagcggcatg 1576981 agtgtacaag aaatgaggca ctaccaacaa tttgtctcaa atcttgataa tacgatctat 1577041 cactatcaaa agcttgtcat tatgaaaaga aatcaaatga atcaaaaaca agaaattttg 1577101 acagagaaaa acattgaagt gaaaaagttt gaaaaaatgc gtgaaaaaca gtttaaaatg 1577161 tttgctcttg aagataaagc tgcagaaatg aaagaaatgg acgatatttc gattaagcag 1577221 tttatgattc aaggccatta ggagcgaatg taatgtccgg caaaaagaaa gaatcaggta 1577281 agttccgttc ggttttgctt atcattatcc tcccgctgat gtttctatta atcgcagggg 1577341 ggattgttct ttgggctgct ggtatcaatg tcttaaagcc gatacaggat gctgcggcaa 1577401 aaacgccggt tcttaaagaa ttggtccctg aaaccgaaaa taaaaaaggc gcagcatcaa 1577461 gtaaggatag cagtaatacg gcagctctgg aaaagaccat taaggatcaa aaaagtgaaa 1577521 tcagtatatt gaataaagat ttagaaacaa gtaaatcaga aatcgacagg ctcaatcaaa 1577581 agatccgttc acttgaaaag acggctgagg atcaaaaaaa gtcatcagaa gatcatactg 1577641 aaggatcagc agactcgaaa gcttcttctg aaaatgacaa agtgatcagt gtgtacaaaa 1577701 gcatggacag cggaaaggct gctaaaatta ttgcccaatt aaaggagcaa gaagcactga 1577761 aaatattgaa tggcctaagc aaaaagcagc ttgctgacat attggcgaaa atgactcctg 1577821 agcaagcagc aacctataca gaaaaaattg ctgccagcca agaatagggg gaatgaaagg 1577881 tgaagctgct tgaattagcc ggacctttgc tgcaaaccac aacgggttct gccgctaaaa 1577941 acatgaaaag tagccaggga gtttttcaaa actggcttat gtctgaggct ggattgaagg 1578001 aactttcaga acaaggaaag ggaactccta attctgaaga tcagctttta gcagatgcgc 1578061 ttaaaaagat cggtgaatgg ctaaatgcaa gtcctgaaga tcaagacaaa caaaatgcgg 1578121 atcttttgca aacattaagc aaactgacag ggaagcaatt ggatgcgaat gctctgcaaa 1578181 tgttgcaaaa tcttttgcaa gcagttgaat caaaaatgtc aggcgggacg gatcaattgc 1578241 tcacagaaac ggagaaaatc ttttcagaag ctaaaacggc tctgagtgcc aatgattctg 1578301 cttctgacat taatggagca ctgaagtctg ataaagagca atcaaatcag gaaaatgaag 1578361 tatccgagcc tgcaaaagag cttatctata tccagatgtt cattagccag ctcgtagaag 1578421 ggaataagct gactgatctc gggaatggca atgaagctca tgccatttac caaaatggag 1578481 atcaattcct ttctgcatta gaaaagaagg gtgtatctca acaactaatt caggatctta 1578541 aacagcaaat attcactaaa gctgagtcaa gttcaaaact ttactcgatg acagcgtcag 1578601 agctgaaaag ttttcaaagc ttaatggatc aaatgtctat gcttcctcaa aaagggacca 1578661 aagaatggag tttagctgaa agccagctga aagccttctt gttatcgaaa tcatccgaat 1578721 catcacaaga ctttgggaag agtgttctca caccgctctc gcagagttca tccagcaaaa 1578781 atgcatcgga tgtttctgga agtattcagc ctgtagatag taaatcagga ctccaaatgc 1578841 tgttttcggg gtatcggggc ataggaggag ttcaaacact tgatctgcag cagatgtcat 1578901 ctgatatacc aaatgccgaa acaaaaacgg tggctgatca agtgattaat gcgtggaagc 1578961 agatgaaata tacgcctttc ggcagatcga cgggaagttt cactattcgg ctgaaccctg 1579021 aacatttagg atttgtcaca atcaagctga caaatgaaaa tggaatgttt cagagtaaaa 1579081 tcatagcatc tagccaatca gcaaaagaat tgcttgaaca gcatcttcct cagctgaagc 1579141 aatcattgcc gaatatggcc gtccaaattg accgttttac tcttccggtc caaagcgggg 1579201 atcagccgat atacggccag cttgctgatg aacagaaaca gcagcaagag gggcagagac 1579261 agcaaagaca gaaaaagcaa tcaaatgatt ttggcgatct gctcgatgaa gtgtcgatgg 1579321 ttgaaatgga ggaagaagaa tgacttctat aagttcagaa tataaactgc ctgaaaaaac 1579381 gaacactgtg tcgacgaaca acagcagctt ggggaaagac gagtttttaa aaatattaat 1579441 gactcaagtt caaaaccaag atccgcttaa cccgattgac gataaagaat ttatcagcca 1579501 gatggcgact ttttcaagct tggagcaaat gatgaatctg aatacgacaa tgactcaatt 1579561 cgttgaaaac caagatccgt ttacaacgta tgttgattgg atgggaaaag aagtatcttg 1579621 gactgatggt aaaagtgcaa cagataaaac aggcacagta agctctgtta aacattttaa 1579681 aggaaattat tatctcgttc ttgatgatgg gaccgagatc agtcctgcga atgtcatgtc 1579741 tgtgggacaa tcatctaaat aaaaacatct gggggaatat attatgttac gttcacttta 1579801 ttctggaatc agcggtatga aaaactttca aacaaagctt gacgtaatcg gtaacaacat 1579861 tgccaacgta aatacagtag gattcaaaaa gagccgtgtg acctttaaag atatggtaag 1579921 ccaaacgatt gccggcggtt ctgctgctgg tgcaacaatc ggcggaacaa actctaagca 1579981 aatcggttta ggttcatcat ctggcacaat tgatacaatt cattcaacaa gcgcgacaca 1580041 aagcacagga agaacacttg atttagcaat tgacggcgac ggttacttcc gaattgatac 1580101 aggtgacggg acagcttata caagagcagg gaacttctat ttagataata ctggaacact 1580161 ggttacaggt gatggctacc atgtactaaa tatgaatggc ggaacaatta aaattcctac 1580221 tgatgctcaa agctttagca ttggttctga tggaaaggtg tcaattgttg atgctgaggg 1580281 gaaaacacaa gacgggggac aaatcgggat tgttactttt gccaacagtg atggattgga 1580341 taaaatcgga agcaacctat accgtgaatc tttaaactct ggaacggcca gtgcagcgaa 1580401 ccagcctggt gacggcggaa ctggtgctct taaatcagga tttctcgaaa tgtctaacgt 1580461 cgatttaact gacgaattta ctgaaatgat cgtagcccag cgcggattcc aatcaaactc 1580521 aaaaattatt acaacatctg atgaaatcct tcaagaactg gttaacctta aacgttaagg 1580581 agggagggga ggcgagtaat cgcttctccg ctgttttatg attaaagtaa cccgtttgaa 1580641 cgggcagccc tttacactga atgcgctatt tattgaacag attgaatgtt ttccggatac 1580701 tacaattact ctgtcaaatg gtaagaagtt tgtagtaaaa gaagatgaag aagctgttct 1580761 ggaaaagatc gcagctttct accgaaaaat acaaatattt gcaatggatc aaggaataga 1580821 ggaaccggaa tgaagaaaaa gttaatgatc atattactaa ttattcttat cgtaattggt 1580881 gctctcgggg cggcggctta ttttgtttta ggcggaaagt ccgaaaaaag tgaagcgaaa 1580941 aaaagtattg atgaaatcgt tgcgtcttct gttgatgtag aagagatcac aacaaattta 1581001 aagtctgata acattatccg tcttgctatt aaacttgaaa ctgattctga taaatcaaaa 1581061 gaagaacttg agaaacgtga tttccaagtg aaagacgctg ttatatcact gctggctgat 1581121 acgaatgctg atcagattga gggagacaag ggaaaagaaa cctttaagaa ggaactaaaa 1581181 gataaaataa atagctacct ccaagaagga aaagtagaaa aagtgtatat tacctccttt 1581241 aatctgcaat aaagcataat ttgacagaat acggaggtga ggaaaatgtc aggagaagtt 1581301 ctctcccaaa atgaaataga tgcactgctc tctgcaatat caactggtga aatggacgct 1581361 gaagagctga aaaaagaaga aaaagagaag aaagtcaagg tttatgattt caaacgtgcg 1581421 ctgcggtttt ctaaggatca gatccgcagt ttaacgagaa ttcatgacaa ttttgcaaga 1581481 cttcttacca ctcatttttc tgctcagctc agaacctata ttcacatatc tgtcagttct 1581541 gttgatcagg ttccgtatga ggaatttatc agatcgattc caaacatgac gattctgaat 1581601 ctatttgatg ttcatccgat ggaaggaaga attatgatgg aggtcaaccc cacgatagct 1581661 tatacgatga tggatcgagt catgggcggg attggaatca gtcataacaa ggttgacagt 1581721 ttgacagaaa ttgaaacaaa aatcatttct aatttatttg aaaatgcact gggtaattat 1581781 aaagaagctt ggcagtcaat tgctgatatt gaaccggaaa tgactgagtt tgaagtgaat 1581841 ccgcaatttg ttcagatggt atctcctaat gaaacagtcg tggtgatctc gctcaatact 1581901 caaattggtg aaatcagcgg tgtcattaat ctctgtatcc cgcatattgt actcgagccg 1581961 ctcataccga agctttcagt ccactattgg atgcaatcag accgaaatga gccaaagcct 1582021 gaggaaacaa agtcgcttga aaaacgtatc atgacagcac aaatacctgt cgtggccgag 1582081 ctcggcacat ctgaactgac gatagaagag tttttaagtt tagaagtcgg agactgcata 1582141 actttggaca aatcagtcac ggatcctctt actgtattgg tcggagataa gccgaaattt 1582201 ttaggacaag ccggccgggt gaatcgaaaa caggcagtgc aaattttaga tcacgacata 1582261 agaggtgaac aagatggaga ataatagatt atctcaagat gagattgacg cgcttcttaa 1582321 cggtactggc agcacgcttg atgagccaga gattccggaa gtagatgact tatcggaaat 1582381 ggagcgtgat gcgatcggtg aaatcggtaa tatttcattc ggcagttctg cgacagcact 1582441 gtcaacgctt ttaaatcaaa aggtcgatat tacgactcca agcgtaacgg tcattccaag 1582501 aagtaaaatc agcgatgcgt ttcctgaacc gtatgtagcg attgaagtga attatacgga 1582561 gggcttcagc ggaagcaacc tgttagtcgt ggaacaaagt gacgcggcga tcattgcgga 1582621 cttaatgatc gggggagacg gaaaaggtgc ggacccttca ctgggtgaaa tccatttaag 1582681 tgcggttcaa gaagcaatga accaaatgat gggatcggct gccacatcaa tgtctactgt 1582741 attcagtaaa aaaattgata tttcacctcc tcgggttgaa ttgctggatg ttactgaaga 1582801 aaagggtaca gaccgtattc ctgatgatga aatgctggtg aaagtttctt tcaacttaaa 1582861 ggtgggagaa ttaatagact ccagcattat gcaactttac ccattgacat ttgcgaaaga 1582921 tttaatttca agccttatga actcagaaag tgcagaggaa gaagaaacgg tgcagcctga 1582981 agttacatac gaacagccga aagagcctgt gacgccagag ccgcgtattg aaccgaagca 1583041 acagcagcag ccgccaaaaa ggcagggaac agcaaaaaaa gcagcgccag ttcaggtttc 1583101 accggtggaa ttttccgcgt ttgatccaaa cgaagctgta caagccccta ttcataatct 1583161 ggatatgctt ttggatatcc cgctttcgat tactgttgag cttggcagaa cgaagagaag 1583221 cgtaaaagag attttagagc tttctgccgg aagtattatc gagcttgata aattagccgg 1583281 tgagcctgta gatattttag ttaatcagcg tatcgttgcc aaaggcgagg tcgttgtcat 1583341 tgaagaaaac ttcggagtga gagtcactga cattttaagc caggcagagc gcattaataa 1583401 tttaaaataa cgaaacacaa ggagagagat agattatggc acatagaatt ttaattgtag 1583461 atgacgcagc atttatgcga atgatgatta aagatatttt ggttaaaaat ggttttgaag 1583521 ttgtggcgga agctgaaaat ggagcacaag cggtagagaa atataaagag cattcacctg 1583581 accttgttac tatggatatc acgatgccag aaatggatgg tattacagca ttaaaagaaa 1583641 ttaaacaaat tgatgcgcag gcaagaatca tcatgtgttc tgctatggga cagcaatcaa 1583701 tggttattga tgccattcag gccggcgcta aggatttcat tgtgaaacct ttccaggctg 1583761 accgtgtgct tgaagcaatc aacaaaacat taaattaaag ggtgtacgac tgttgaaaaa 1583821 gagtcaatat tttattgttt ttatttgttt tttcgtttta ttcagtgtac atccgattgc 1583881 tgctgccgcg gcagactctg ataattcaac tgtaaacgaa tggtttcaaa agaaagatga 1583941 aaaaactgca gatcaatcag agcaaaagaa agaaaaaaca acaaaaactg ctgatgagac 1584001 ggagggagcg gctgctcctt ctgtctcagc ttttgatttt gtaaagatga ttttcgcttt 1584061 actgtttgtt atcgtgctga tttacgggct ggttaagctc atgaacaaaa gaaatcggct 1584121 cctaaagcct tttcaatatg ttgaaaatat tggcggcaca tcggtcggtc agaacagatc 1584181 catacaattg atcaaggtcg ggaaaagtgt gctcgtcgtc ggtgtaggag agacgatcca 1584241 gctgctgaaa gaaattgagg atgaaaaaga gattgaagtc attctcagtc agcatgaaga 1584301 ggcaatgtca agcaaaatag agtggcaaaa gtttgtgaag ccgcttaaga gttctgaaca 1584361 tcagccgcag caaaaactgc cttcattttc aaaagcatta aaagagcaac ttgaagagtt 1584421 aaaacaaaac cgttctgaag gaaagaagaa aggcccacgt catcatgaat gagtttataa 1584481 atattttcag ttcaagcgat ccggaaaacg taagttcgac tgttaaatta ctattattgt 1584541 taactgtatt ttcagtggcg cctggaatat tgattcttat gacttgtttt actcgcatcg 1584601 tcattgttct gtcatttgtc agaacttcac ttgcgacgca atctatgccc ccaaaccagg 1584661 ttctaatcgg gcttgcgctg tttttaacat tttttattat ggctcctact ttttcagaaa 1584721 ttaataaaga agcgctgacc ccattaatgg acaacaaaat cagcttggat gaagcgtata 1584781 cgaaagctga ggaaccgatt aaagaattta tgagtaaaca cacaaggcag aaggatctgg 1584841 cgctgtttat gaattacgcg aaaatggata aacctgaatc attaaaggat attccgttaa 1584901 caacaatggt tccggctttt gccatatcgg agcttaaaac agcatttcaa ataggtttta 1584961 tgatttttat ccctttttta attatagata tggtagtggc gagcgtcttg atgtcaatgg 1585021 gaatgatgat gctgcctcca gttatgattt ctctgccctt taaaatatta ctttttgttt 1585081 tggtagacgg ctggtattta attgtgaaat ctttgcttca gagcttttag ggtaggtgct 1585141 aaacgtgagt tcagaatttg taatttctat ggcggaaaaa gccgtatacg taacgctgat 1585201 gatcagcggg ccattattgg ctattgcttt actggtcggt ttaattgtca gcatatttca 1585261 ggcgacaact caaatccagg aacagacttt ggcgtttatt ccgaaaatcg tggcggttct 1585321 cctggctctc attttttttg gtccgtggat gctgtcgacg attctttcat ttacaacaga 1585381 gctgttttct aatttaaatc gttttgcagg gtaatgtaga gatgaattca attattgact 1585441 tatttcctgc ttttttattg gtttttatta gaatctctgc tttttttgta acgattccgc 1585501 tatttggaca tcgaaatgtg ccagctgttc atcgcatagg ttttgctttt tttcttgcgg 1585561 tcatttgttt cagcaccatt gataaaccgc cctctttgga gatagatgag cactatatgc 1585621 ttttggcgtt taaagaagct ttggtcggcc tatgtctggg tttaattgct tatatgatga 1585681 ttgccgcagt gcagattgcc ggctcgttta ttgattttca aatgggattt tcaatagcaa 1585741 acgttattga tccgcaaacc ggtgcacaaa gtccgttgat tggccagttt atctatacga 1585801 tggcactttt gtttatgctg agtgtcaatg cccaccattt gttgctggat ggtatttact 1585861 acagctttca gtatatttca gttgatcagg catttccgaa tttcggcgat gaaaagtttg 1585921 cctattttat tgcgaaaagc tttaatgcaa tgtttattat cgcttttcaa atgtcagcgc 1585981 cggttgtggc cagtttgttt ctagttgatt tagcattagg tatcgtggct cgaactgttc 1586041 cgcagttaaa tgtatttgtg gtcggtctgc ctttaaagat cgctgtcagt ttcattatgc 1586101 tcattgtatg tatgtccgtt atcttcgtcg ttgtccggaa tgttttcagt ttaacgattg 1586161 aaacgatgcg gaatctttta gcattggtcg gtgtttctta atgaagctta gagttgacct 1586221 gcagtttttt gcgggagaga agacagaaaa agccactccg aaaaaacgga aggatacgcg 1586281 aaaaaaaggg caggtagcca aaagctcgga tgtcaatacc gccgtttctt tactggtaat 1586341 attcctttcg cttattgcaa ttggtccgta tatgagagac aggctgctgt cattcataga 1586401 aacattttat accgaatcgc tcacaatgaa gctctcagaa tcaaatgtgc atacattgtt 1586461 tgtcagctta ttaaaggata tgggcatgat actcgcaccg atcttgcttg ttgctcttgt 1586521 tgcaggagtc gtaagcaact atatgcaggt tgggttcttg ttttctgctg aagtgataca 1586581 gcctaagctt gaaaaactgg atccgatcaa aggctttaaa cgaatataca gtatgagggc 1586641 gattgtagag ctgattaaat caattttgaa aatcgtagtc gtcggttttg cggcttttgc 1586701 tgtgctttgg ctgcattatg gagaaattct ccggcttcct ctcctgacac ccgaagaggc 1586761 actttctttc gtttcaaaac tcactttgtg gatgggacta agcggtgcag gtgcattgtt 1586821 gattcttgct ggtctcgact atttatatca gagatttgac tatgagaaaa atatcaaaat 1586881 gtcaaaacaa gatataaaag atgagtacaa aaaatctgaa ggagacccga ttatcaagtc 1586941 taaaattaaa caaagacagc gggaaatggc gatgaggcgg atgatgcagg aagttccaaa 1587001 agcagatgtc attatcacaa acccgactca ctatgcgatt gctttgaaat atgatgaaga 1587061 aaaaatggac gcaccttata ttgttgcaaa aggcgtcgac caccttgcgt taaaaatcag 1587121 gaaaattgct aaagagcatg atgtcatgat ggtagaaaac agaccgcttg cccgtgcgtt 1587181 atatgatcaa gtggaaattg accaggcagt gccggaagaa ttttttaaag ttttagcaga 1587241 aattctggct tacgtatata aaacaaaaca aaaagtatat tgaatttttc gatttaaaag 1587301 gagagaaaaa acagcatgtc aacaagagat ttatccgttt taataagtgt tgtcctcatt 1587361 gtggcgatgc tggtgattcc atttcctcca tggctgttaa gtattttgat cattattaat 1587421 atttctcttg cgttgatcgt gcttctcacc acaatgaata tgcaggaagc gcttcagttt 1587481 tcgatttttc cgtcactgtt gctgcttttg accctatttc gtttgggctt gaacgtctca 1587541 actacccgtt caattctttc acacggtgag ggaggtaaag tcgtcgagac tttcggaaat 1587601 ttcgttgtcg gcggaaatgt attagttgga ctcgttgtat ttatcatcct tattattatt 1587661 cagtttatcg tcattacaaa aggtgctgaa cgtgtttccg aggttgcagc aaggtttacg 1587721 ctggacgcaa tgccggggaa gcagatgagt attgatgctg atttaaacgc agggatgatt 1587781 accgaacagg aagcgaagca tcgccgcgaa aaagtggcaa gagaagcaga cttttatgga 1587841 gcaatggacg gtgccagtaa atttgtaaaa ggtgacgcca ttgccggaat catcattgtg 1587901 atgatcaata ttattttcgg aatcgtgatc ggaatgcttc agcagggcat gtccattcaa 1587961 gaagctgctt cacactttac gatgctgact gtaggggatg gaattgtttc gcaaatcccg 1588021 gcactgttaa tttctacggc tacgggtatt gtggtcacaa gagctgcatc tgaaggaaac 1588081 ttagggcatg acattacagg ccagctgttt gcgtatccaa agcttttata cgtcgcagca 1588141 gctacgatca tgcttttagg tattttcact ccgatcggca tccttctgac ggggccgctt 1588201 gcgggattgc ttgcttttgg cgcatataca ctatctaaat caggtaagga aaaagaagaa 1588261 gtggatgaga ttcttgagga agaggctgag gtggacgagc ttaaaagccc tgaaagtgtt 1588321 gttcagcttc tgcatataga tccgatagaa tttgagtttg gatatggcct gataccgctt 1588381 gctgatgcca atcaaggcgg tgatttatta gaccgaattg ttatgatacg ccgtcagttg 1588441 gctttggaac tcgggcttgt cattcctgtc gtgcgaatca gagataatat agcgttgcag 1588501 cctaatgaat accgattgaa aattaaagga aacgaagtag caaaaggcga gctgttgctt 1588561 gatcattatt tagcgatgtc gcctactcct gaggacgatc tcattgaagg gattgaaaca 1588621 gtggagcctt cattcggact gccggctaaa tggattagcg aagcggtaaa ggatgaagcc 1588681 gacatgcttg gttatacagt agttgatcct gcatcagtcg tttcaacgca tattacggag 1588741 aaaattaagc agcatgccca cgaattgatc ggaaggcagg agacaaaaca gctgatcgat 1588801 cacttgaaag aatcgtatcc agtcctggtt gaagaggtta cgccgaatcc attgtctgtc 1588861 ggtgatattc agaaagtgct tgctaagctt ttaaaagaaa aagtttcaat tcgaaactta 1588921 gtaacgattt ttgaaacact tgctgactat gggaaattaa caacagattc tgatctcttg 1588981 acagagtata caagacaagc gcttgctaaa caaattacag cccagtttgc caaagaaaat 1589041 gaagtgttga aggttgttac ttgttccggc cgtgtagaaa aagcaatagc agacggtgtg 1589101 cagcagacgg aacacgggaa ctatttatca cttgaaccag atatttcaga aagtatagtg 1589161 cgctctgtcg ccaaagaagc tgaacagctc tcattacgtc aggaaaccgc gattcttctt 1589221 tgctcgccgc ctgtcagaat gtatgtgaag cagctactgg aacggtactt ccctgatctt 1589281 ccggtactct cttataacga acttgaggcg aatgttgagg tacaaagcat tggagtggtg 1589341 gatatttaat gaaaataaaa aaatttactg ctgcttcaat gcaagaagcg gcacttctca 1589401 tcagaaaaga gttaggtaat gaagcggtca tattaaattc gaaaaaaatt aaaaagcgaa 1589461 aatggtttgg cctcgtcaac aagcctgctg ttgaagtaat cgccgtattg gatcaggact 1589521 ttcttgagaa aaaaacgcct cagaaggcag ctgaaccgaa acaaacatta aaaactccgg 1589581 tcagcagtcc aaaaatagag gagagaacat atccccctca aattccggcg caacaggagc 1589641 taggtgattt ttcagcatat caatctgtac ttcctgagcc gctgcgaaaa gcagaaaagc 1589701 ttttgcaaga aacagggatc aaagagtcta cgaaaacgaa cactctgaaa aaattgcttc 1589761 gcttctctgt tgaagcaggc ggcttgactg aagaaaatgt tgtcggcaaa cttcaggaaa 1589821 tactatgcga tatgctgccc tcagcagaca agtggcagga gccaattcat tcaaaatata 1589881 tcgttctctt tggttcaaca ggggctggta aaacaactac actggctaaa ctcgcagcca 1589941 tatctatgct tgaaaaacat aaaaaaatcg cttttattac aacagatacg tatcgtattg 1590001 cagctgttga acagttgaaa acatacgctg aactgctgca ggctcctctg gaagtttgct 1590061 atacaaaaga agaatttcag caggcgaagg agctattttc tgagtatgat catgtgtttg 1590121 ttgatacagc tggaagaaac ttcaaagacc cgcaatacat tgatgaactg aaagaaacga 1590181 ttccttttga gagcagcatt cagtcatttc ttgttttatc cgcgactgca aaatatgaag 1590241 atatgaagca tattgtcaaa cggttttcat ccgtccctgt caatcagtat atttttacga 1590301 aaatagatga aacgacttcc ttaggttctg tatttaatat actggcagaa tcaaaaatag 1590361 gtgtcgggtt tatgactaac ggccagaatg tgcctgagga tatacagact gtatctccac 1590421 ttggttttgt gaggatgctg tgcagatgaa cagatatgac caagcagcaa ctttacgggc 1590481 gaaaatggaa aaacgtgagc gcgttctgcc aatggtttat tcacaaaaag cgaagacact 1590541 tgctgtcatc agcggcaagg gcggtgtcgg aaaatccaat attaccttaa atatggcact 1590601 tgcgctgcag gataaaggta agaaggtgct gctcatcgac cttgatatcg ggatggggaa 1590661 cattgatata ttaataggaa attcatcgtc tgccacgata atcgatgttt taaccgatcg 1590721 taagcctttg ctgcagtcat tatccgttgg cccaaagggt ttgcggtata tatcaggggg 1590781 aaccggtctt gatgtgatgt ttcagctcga tcagagaaaa tggacgtttt ttgccaatga 1590841 actttctcat gcattaagcc agttcgatta tgtgctgttt gacatgggag caggcttatc 1590901 aaaagatcaa ctgcctttta ttttatcagc agaagatatt ttgattatta caactcccga 1590961 gccgacggcc attatggacg catacagcgc tgtcaagcac ttggttttga cagaaaataa 1591021 gctttcaatg aaggtggctg tcaatcggtg ccgtgaccaa aaggaagggc ttgacgcttt 1591081 tgcccgcctc tcccgtacaa ttcatatgtt tttggatgtt caggttcagt ttgccggttc 1591141 cgtttctgac gatgtgatcg tgagcaaagc ggttgtcgaa caggttcctt ttttcataaa 1591201 aagccctcag gcaaaagcca gccggtcagt ccgtatttta gcggacgcct tgtttgaaag 1591261 agaagaaacg agacacaaag aagacaaaca gacatttatt gagaaattat cttctttttt 1591321 aatgaggagg gcttaatttg attcgtgtgc ttgtagttga tgattcagct tttatgagaa 1591381 aaatgataag tgattttctg accgaagaaa agcagataga agtaatcgga actgcgagaa 1591441 acggagaaga agcgcttaag aagattgaat tattaaaacc ggatgttatt actcttgatg 1591501 ttgaaatgcc ggtcatgaat gggacagata cgctccgcaa aattattgag atttataact 1591561 tgccggtcat tatggtgtct agccagaccg agaaaggtaa agaatgcaca attaattgtt 1591621 tggagatcgg tgcctttgac tttatcacaa agccatcagg ctcaatatct ctggatctat 1591681 acaaaattaa agaacaacta gttgagcgtg tcgtcgcggc aggactttcc ggcaagcgga 1591741 aacgtcctgt ttcccagaca gttcggcccg aacctattgt gcgtgctgtc gttaagcctg 1591801 aattaagcaa accgaaacct ggcacgggca gacaaattgt gtgtatcggc acatcaacag 1591861 gcggtccacg ggcgttacaa aaggtgatac cgaagctccc taaggatttg aacgcaccag 1591921 tggttgtcgt tcagcacatg cctgaagggt ttactgcttc tttggctgat cggctgaatc 1591981 atttatctga cattcaggta aaagaagcaa aagatggtga agcagctctt aacggctgtg 1592041 tttacatagc accgggcgga aaaaacatat ccgttattaa aaacagcgaa ggactccagg 1592101 ttgtgcttga taaccatgac acaccaagcc gtcataaacc atctgctgat tatttattcc 1592161 gttctgtcgg gaaactgaca gattatgaaa aagtagcggt tatcatgacc ggaatgggca 1592221 gtgacggcac tgctggacta aaggacatgc taacagccgg caatgtgaaa gccattgcgg 1592281 agtctgaaga atcttgtgtc gtatacggga tgccaaaagc tgctgttaaa gcgggtctca 1592341 ttcatgagat taaacatgtg gaagatatcg cagcatccat cacaagctgt gtgaaaaaag 1592401 agagggtgtg attcaaatgg atatgaatca gtatttagat gtctttattg atgagagtaa 1592461 agaacattta caaacatgta atgaaaagct tcttctttta gagaaagacc cgactgatct 1592521 tcagctcgta catgatatat tcagggctgc ccatacatta aaaggaatga gcgcaacgat 1592581 gggctacacg gatttagcac atcttaccca tctgcttgaa aacgtgctgg atgcaatccg 1592641 aaacggagac atggaagtca cctcagactg gctggatatt ttgtttgaag ctctggatca 1592701 cctggaaaca atggttcagt ctattattga tggcggggat ggtaaaagag atatctcaga 1592761 agtgagtgcc aagcttgatg tgaatggtgc gcacgctgaa tccgctgcct ccgctgaacc 1592821 tgcagaagca cagagttcag catctgattg ggaatatgat gaatttgaac gcacagttat 1592881 acaagaagcg gaggagcaag gcttcaaacg atatgaaatc aagatttctc tgaacgaaaa 1592941 ctgtatgtta aaagcagttc gtgtctatat ggtgtttgaa aaactaaatg aagtcggaga 1593001 agtagccaaa acaattccaa gtgctgaagt gcttgaaaca gaagattttg gaactgactt 1593061 tcaagtttgt ttcttaacac atcaatcagc ggaagacatt gaacaattaa tcaatggcgt 1593121 gtcggaaatt gagcatgttg aagtcattca aggggctcct ttaacatcag ctgaaaagcc 1593181 tgaagaatct aagcaagaag attcaccagc agcagctgta cctgcgaagc aggagaaaca 1593241 aaaacagcct gctaaaaacg atgaacaggc gaagcattca gccggcggat ctaaaacaat 1593301 tcgtgtcaac attgacaggc ttgattcttt aatgaactta tttgaagagc ttgtcattga 1593361 ccgcgggcgt ctcgagcaga ttgcgaaaga gcttgagcat aatgaactga ctgaaacggt 1593421 tgaacgaatg acgagaattt ccggagattt gcaatcgatt attctgaata tgagaatggt 1593481 cccggttgaa actgttttta acagattccc gagaatgatt cgccagcttc agaaagagct 1593541 gaataaaaaa attgaactct cgatcatcgg tgcggaaact gaactggatc gtacagtaat 1593601 tgatgaaatc ggagatccac tcgttcactt gatcagaaac agtattgacc atggtatcga 1593661 ggcgccggaa acacgtttgc aaaagggaaa accggaatca ggaaaagttg tgcttaaagc 1593721 ttatcacagc ggcaaccatg tctttatcga agtagaggat gacggcgcag gccttaatcg 1593781 aaaaaaaatt ctggaaaaag cgcttgagcg cggggtcata acggaaaaag aagctgaaac 1593841 cttagaagac aaccaaattt acgaattgat ttttgctccg gggttctcaa ctgctgacca 1593901 aatttctgat atttccggcc gcggtgtagg acttgacgtt gtaaaaaaca aactggagtc 1593961 tcttggcggt tcagtcagtg tgaaatcagc cgagggtcaa ggctctctat tcagcatcca 1594021 gctgccgctt accttgtcta ttatttcagt tctgctgatt aagttggaag aagagacatt 1594081 tgccattccg atttcttcaa tcattgagac agcagttatt gacagaaaag acattttgca 1594141 aacgcatgac cgtgaagtga ttgactttag agggcatatt gtccctgtcg tttatttaaa 1594201 agaagagttt aaaatagaag atacaagaaa agatgcggaa cagctccata tcattgtcgt 1594261 gaaaaaaggc gacaaaccta ctgcatttgt ggtggactcc tttattggcc agcaggaagt 1594321 tgtgctgaaa tcactcggag attatttaac aaacgtcttt gcaatttccg gagctactat 1594381 tttaggagac ggagaagtag cgctcattat tgattgtaat gcactgatta tttaaccatt 1594441 cgaggaggtg tctcacatga ctgcagaaat taaaacaggc gaaaaaatga tagtctttat 1594501 ggtaaatggc aaagaatatg ccatttccgt cactcaggtg aaatcaattg aaaaatggca 1594561 aaagccaacg agggtacctg gcgtcgaacc atatatttgc ggggtaatca atttacgcgg 1594621 ggtggtgact ccggttattg atttaagaaa acgcctgaat ttgccagagt atgaaattac 1594681 agatgaaaca cgaattatca ttattgctta tcgtgatatt gaagtcggct ggattgtgga 1594741 tgaagcgaat gatgtgatta ccgtacacga aagtgaaata gaatctgctc cagaaggcgt 1594801 tcagaaagat acggatgtgt cgatcgaaca gattgtgaaa caagagaaca gactcttaaa 1594861 tattattgat gcgaacgcgg ttttggataa agaatcatct cagtccgctg tgcccgatca 1594921 agcttaatct taaaggggtt atgacatgag tatttttaat ggaatcaaag aagagcagat 1594981 ggacattttg cgggaagtcg gcaatatagg cgccggccac tccgcctctg caatggccca 1595041 gctgttaaat agaaagatag atatggaagt cccatttgca aagctgctgt cttttgatga 1595101 gcttgttgat tttttcggcg gcgccgatgt cccggttgcc agcatctttt taagaatgga 1595161 aggcgattta acgggttcaa tgttctttat aatgcctttt tttcaggcgg agcagtttat 1595221 cagagagctg attggaaacc ccgattttga catagaggac ttaggtgaag accacatgag 1595281 ctcatccgct ttgcatgaac tgggcaatat tttagcgggg tcatatttaa cagctttggc 1595341 ggatttgacg aaactccagc tctatccaag tgttcctgaa gtctcattgg acatgttcgg 1595401 agctgtgatc agcgaagggc tgatggagct cagtcaggtt ggagaacacg ccattgttgt 1595461 cgacacgtca atttttgacc aaagccatca gcaggagctg aaagcgcata tgtttatgct 1595521 gccggactat gattcatttg aaaagctctt tgtcgcctta ggtgcatcat tatgagtaca 1595581 actgaggctg ttgttataaa ggttgggatt gctgacgtga agatcgcccg cttcccggat 1595641 accatccgga cctctggttt gggctcatgt gtggggctgg tgctttatga taaagaaaag 1595701 caaacggcgg gtcttgttca tgtcatgctt ccggattcga cgttatcgaa aactgccgag 1595761 ctcaaccggg ctaagtacgc tgacaccgcc gtacagacca cgattgatat gctgatagaa 1595821 gcgggatgcc ggaaatttgc attaaaagca aagctggccg gcggatcaga gatgtttaaa 1595881 tttaaatcga caaatgattt gatgaagatc ggaccgagaa atgtattagc gataaaagaa 1595941 cagctgtctt tatttaatat tcctattatt agtgaagata cgggcggctc aagcggccgg 1596001 acgatagaat ttgaaccgaa gtcctgcatg ctgcatattc gaactgttaa acaaggtgaa 1596061 aaaacgattt aattaaggta ttagggggat aacaatgcaa tccttgaatt atgaagatca 1596121 ggtgctttgg acgcgctgga aagagtggaa agatcctaaa gccggtgacg acttaatgcg 1596181 ccgttacatg ccgcttgtca catatcatgt aggcagaatt tctgtcggac tgccgaaatc 1596241 agtgcataaa gacgatctta tgagccttgg tatgcttggt ttatatgatg cccttgaaaa 1596301 atttgacccc agccgggact taaaatttga tacctacgcc tcgtttagaa ttcgcggcgc 1596361 aatcatagac gggcttcgta aagaagattg gctgcccaga acctcgcgcg aaaaaacaaa 1596421 aaaggttgaa gcagcaattg aaaagcttga acagcggtat cttcggaatg tatcgcccgc 1596481 ggaaattgca gaggaactcg gaatgacggt acaggatgtc gtgtcaacaa tgaatgaagg 1596541 tttttttgca aatctgctgt caattgatga aaagctccat gatcaagatg acggggaaaa 1596601 cattcaagtc atgatcagag atgacaaaaa tgttccgcct gaagaaaaga ttatgaagga 1596661 tgaactgatt gcacagcttg cggaaaaaat tcacgaactc tctgaaaaag aacagctggt 1596721 tgtcagtttg ttctacaaag aggagttgac actgacagaa atcggacaag tattaaatct 1596781 ttctacgtcc cgcatatctc agatccattc aaaggcatta tttaaattaa agaatctgct 1596841 ggaaaaagtg atacaataat gaatttcatg gttagcgagt gaaaaacatg tcaacactat 1596901 tatggctttt aagctttatg ctccacggcg ttcttctgta cgctgtcatt atcctgtata 1596961 cgaggctcgc tgcagtgaaa gaaacagaaa aacagcaaaa acagatactt gaagagacgg 1597021 aaaacacctt ggcggcattt ctgcttgaat taaaagaaga aaatgagaaa ctgatagaaa 1597081 ataaagcttc atctgcaagt caatcagatg aagaatccca aaagtcaggc cttcagacct 1597141 ctgaaacata tcaagagcgg gatccagtcc aagaggcaga gaatcttcct gaacatattg 1597201 aaggtctgat tacagaggtt gaccgtcggg aagagctcgt aaacagtgag gtccaatcat 1597261 ttgaagacca ggtcatagaa ttatatgaac agggatattc ggcaagtcaa attgcccaga 1597321 aaatgaagag cggaaagaca gaaatcgagc tatttttaaa atttcgctcc aaaggtgtaa 1597381 aggattcttg attgtcggat aaagctgtgt tatattatgt cttggtgtta aatacacacg 1597441 cttaacgatt tatgcagagg gtgctgcagg cggcagttct gtacaaaaat gacctaagcg 1597501 gaggaaaaaa accattatat taggaggaaa taacatgtca gtcatttcta tgaagcaatt 1597561 gcttgaagct ggtgttcact tcggtcacca aacacgccgt tggaacccaa aaatgaagcg 1597621 ttacattttc acggagcgta acggaatcta catcattgac cttcaaaaaa cagtcaaaaa 1597681 agtagaggaa gcttacaact tcactaaaaa tcttgctgct gaaggcggaa aaatcctttt 1597741 cgtcggaaca aaaaaacaag ctcaagattc tgttaaagaa gaagctcaac gctctggcat 1597801 gtactatgtc aaccaacgct ggttgggcgg tacattaaca aacttcgaaa caatccaaaa 1597861 acgtattaaa cgtcttaaag acattgaaaa aatgcaagaa aacggtacgt ttgatgtact 1597921 tcctaaaaaa gaagtcgttc aattgaaaaa agaattagag cgtcttgaaa aattcctagg 1597981 cggaattaaa gatatgaagg atcttcctga tgcattattc atcatcgatc ctcgcaaaga 1598041 gcgcatcgct gttgcggaag ctcgcaaatt aaacatccct atcatcggta tcgtagatac 1598101 taactgtgat ccagatgaaa tcgatgttgt tatcccagcg aacgatgacg ctatccgcgc 1598161 tgttaaactt ctaacttcta aaatggcaga tgcaatctta gaagcgaagc aaggcgaaga 1598221 agaagcggaa gttgctgaag aaactgcacc agaaacagaa acaacaactg cgtaacctat 1598281 tcaaaaggtg ataagaggga ctgcctttta tcaccttttt tcaagaaaaa tgtgtaatat 1598341 acatactctt gtttaaacat ataaggagga atacaaatgg caattactgc acagcaagta 1598401 aaagaactgc gtgaaaaaac tggcgcgggc atgatggatt gtaaaaaagc gttaactgaa 1598461 actgacggag atatggacaa agcaattgac cttttaagag aaaaaggaat tgcaaaagca 1598521 gcgaaaaaag ctgaccgtat cgcagcagaa ggttctactc ttattaaaac tgacggcaac 1598581 aaaggcgtta tcctagaagt aaactctgaa actgatttcg ttgcgaaaaa cgaaggtttt 1598641 aaagagcttc ttaacacttt agctgaccac cttcttgcaa acacgccagc tgatgttgaa 1598701 gaagcaatgg gccaaaaaat ggaaaatggc tcaactgttg aagagtacat cacaagcgca 1598761 gttgctaaaa tcggtgagaa aatcactctt cgccgcttta cagttcttac aaaagacgac 1598821 agctctgcat tcggtgcgta ccttcacatg ggcggccgca tcggtgtatt aactgttctc 1598881 aacggtacaa ctgatgaaga aactgcgaaa gatatcgcaa tgcacgttgc tgcagttaac 1598941 cctcgttaca tttctcgtga tcaagtatct gaagaagaaa caaatcatga gcgtcaaatc 1599001 ttaactcagc aagccctcca agaaggcaaa cctgaaaaca tcgtagcgaa aatggttgaa 1599061 ggccgtctga acaaattctt cgaagaaatt tgtctattag accaagcgtt cgttaaaaac 1599121 ccagatgaaa aagtgaaaca agttattgca gcgaaaaacg ctactgttca aacttttgtc 1599181 cgctatgaag ttggagaagg catcgaaaaa cgtcaagaaa actttgctga agaagtaatg 1599241 aaccaagtga aaaaataatg gtgaaaagat ttcgcggcta agtcgcgtct tttcaggcag 1599301 tataggggac acattttgtg ttccctattt ttaaaactat atttacaaac ctttttttct 1599361 cttgcataat agaaaacggc aatgtttaca cttggaggtt atcatggaaa aaccaaaata 1599421 caaacgtatc gtattaaagc ttagcgggga agcattggca ggagaacagg gaaatggaat 1599481 taacccgact gtcattcaat ccattgcaaa gcaagtgaag gaaatcgctg agcttgaagt 1599541 cgaagtggct gttgttgtag gcggcggcaa cttatggcgc ggaaaaacag gaagtgacct 1599601 gggcatggac cgcgcgactg ctgactatat gggaatgctg gcgacagtaa tgaattcgct 1599661 tgctcttcaa gacagcttgg aaacactcgg aatccagtcc agagtgcaaa catccattga 1599721 aatgagacaa gttgctgaac cgtacataag aagaaaagcg atacgccact tagagaaaaa 1599781 acgtgtcgtt attttcgctg cgggcacagg aaacccatat ttctcaactg atacgacagc 1599841 tgcactgcgg gctgctgaaa ttgaggcaga cgttatttta atggctaaaa ataacgttga 1599901 cggtgtgtat aatgctgatc ctagaaaaga tgaatcagct gttaagtatg aatcactttc 1599961 ttatcttgac gttcttaaag acggcctgga agtcatggat tcaacagctt cctctttatg 1600021 catggacaat gacattccgc ttatcgtctt ttctattatg gaagaaggaa atatcaaacg 1600081 tgccgttatc ggtgaatcaa tcggaacgat cgtgaggggg aaataacgtg tcaaaagaag 1600141 tattaactca aacaaaagaa aaaatggaaa aagcaattgc tgcttatcag cgcgaattgg 1600201 ctactgtacg cgcaggccgt gcaaatccat cattattaga taaagtaacg gttgaatatt 1600261 acggagcgca gacaccttta aatcagttgt cttctattaa cgtgcctgaa gctcgtatgc 1600321 tcgttatcac gccatacgat aaaacagcaa tcggtgatat cgaaaaagcg attttaaaag 1600381 ctgatttagg tcttacacca acaagtgacg gcaatatgat tcgaattgca attccggcac 1600441 taacagaaga gagacggaaa gaattagtga aagttgtaaa aaaatatgct gaagaagcaa 1600501 aagtagctgt tcgtaacgtt cgccgtgatg ctaacgatga tctcaaaaaa cttgagaaaa 1600561 acggagacat tactgaggat gaactgcgtg cttccactga agacgttcaa aaactgacag 1600621 atgaatatgt gtcaaaaatt gacagtgtca caaaagacaa agaaaaagaa atcatggaag 1600681 tttaatgaaa aactatgtac aatagataat agtgaaaaga ccctctcatg tttacagggg 1600741 gtttttttgt taatactgtt gattacattg attatcagca gggaatgtaa cctttttggg 1600801 tgacggagga atctcatgct caacatactc aaaaattgga agaatcagca aactgcggct 1600861 tccaacttag aacgttatac aaaagaagac atacttaagg gagaaattcc cgaacacatc 1600921 gccattatca tggatggaaa tggccgttgg gctaaaaaac gctctcttcc cagaattgca 1600981 ggccaccatg aagggatgaa ggtggtaaaa aggaccacga agctcgcaaa cgaattaggt 1601041 gtcaaagtac tgacattgta tgcattttca acagaaaact ggaaaagacc gaaaatggag 1601101 gtcgattttt taatgaagct tccggaagaa tttttgaata cgtatcttcc agagcttgtt 1601161 gaggaaaatg tacaggttcg gatcattggg gatgaaacgg ctttgccggc gcacacatta 1601221 cgtgcgattg aaaaagctgt acaggacacg gcgcaaaacg acggaatgat ccttaatttt 1601281 gctcttaact atggaggccg tactgaaatt gtcagtgctg caaaatcact cgcggaaaaa 1601341 gtgaaggaag gctctttgaa tattgaagac attgatgaat cgcttttttc tacttatttg 1601401 atgactgaat ctttgcagga tcctgaactt ttaattcgaa cgagcggcga gataaggctg 1601461 agtaatttta tgctatggca ggttgcctac agtgaatttg tctttactga cgtcttgtgg 1601521 cctgacttta aagaagatca cttcttgcag gcgttaggag agtttcagca gagaggccgg 1601581 aggtttggcg gaatttagag gatggtggac atgaaacaaa gaattttgac aggtgttctg 1601641 gcagcaattg tatttttatt tttggttatt gtcgggaaat tgccgttcac catattaatt 1601701 tatgctatgg gcagtgtggc gctttttgaa cttttacgga tgaaaaagct gaagctggtt 1601761 tcactgccgg gtttgatcgg tcttttatta ttgtggatgt tcttattacc aagccagtat 1601821 tcgttttttg aagcggacgg gatttccaaa atggaaatcg ctttatttgc ggtactgcta 1601881 ttgctgactt acacagtgtt ggtcaagaac acctttactt ttgatgaagt cgggtttatt 1601941 acgcttgcag caatttacat cggaatgtgt tttcattatt ttatcgaaat cagaaatctt 1602001 gaccaatacg gattaacata cattttttat gcgtgtgttg tcatttggtc caccgattcc 1602061 ggtgcctatt ttgtcggtaa atcgcttggg aagcggaaac tgtggcctga aatcagtccg 1602121 aataaaacag tggaagggtt tgcaggcgga attgtcatcg cacttgtatt ggcgacgatt 1602181 tttcagcttg ttgcacaact tccgatcccg tatatctatc tgctgttgat cacgctgttt 1602241 ttgtctgttt ttggacaact gggagattta gtggaatccg ccttgaaaag acattacgat 1602301 gtaaaggatt ctgggaatat tcttcccggg catggcggta tattagaccg ttttgacagt 1602361 ttcttgtttg tcatgccttt cttgtacttt ctgcttgccc ttttttcata aaaaagtcta 1602421 atatgaatat gagactgatc atgcagcaat aagaatagga gtagtggcaa ctttgaaaaa 1602481 tatttgtctt ttaggagcaa caggatcaat cggcgaacag actcttgatg tactgcgtgc 1602541 acatcaagac caatttcagc tggtatctat gtcgtttggc agaaatattg ataaggccgt 1602601 tccaatgatt gaggtctttc agccgaagtt tgtctctgtc ggtgatctgg atacatatca 1602661 taaattaaaa caaatgtctt tttcttttga atgccaaatc gggctgggag aagaaggact 1602721 gatagaagca gcagtgatgg aggaggttga cattgttgtc aacgctttgc ttggaagcgt 1602781 cggtcttatc ccgacattaa aggcaattga acagaaaaaa acaattgcgc ttgcaaataa 1602841 ggaaactctt gtcactgcag ggcatatagt aaaagaacat gctaagaaat atgatgttcc 1602901 gctgctgcct gttgacagtg agcattcagc catttttcaa gctcttcaag gcgaacaggc 1602961 taaaaacatt gaacgcctca tcattacggc atccggcgga agttttcggg acaagacgcg 1603021 ggaggagctc gaatcagtaa cggttgaaga tgcattaaaa catccaaact ggtcaatggg 1603081 tgcaaaaatt acaattgatt cggctacaat gatgaataag ggattagagg tgatcgaggc 1603141 acactggctt ttcgatatac cttatgaaca aattgatgtg gttttacata aggagagcat 1603201 catccattca atggttgagt tccatgataa aagtgtgatc gcacagctcg gaactccgga 1603261 tatgagagtc cccattcaat atgcgctcac ttatcctgac cgattgccat taccagatgc 1603321 gaaaaggctt gaattatggg aaatcggcag ccttcatttt gagaaagctg attttgacag 1603381 gttccgatgc ttacaatttg cttttgaatc aggtaaaata ggaggaacaa tgccgacagt 1603441 gctaaatgcg gcaaacgaag tagctgtcgc tgccttttta gctggcaaga taccgttttt 1603501 ggctattgaa gactgtatcg aaaaggcact aacccgccat caattactga aaaaaccgag 1603561 cctggcggac attcaagaag tggacaaaga tacccgggga tacgtcaatt caatactcac 1603621 ataaggtggt atgttcgtga atacagttat agcgtttatc attattttcg gaacgctcgt 1603681 tttcttccat gaactgggcc atttattgct agcccaaaga gcgggaattc tctgccgtga 1603741 atttgcgatc ggcttcggtc caaagatttt ttctttcaaa aaaaatgaaa cagtttatac 1603801 gatcaggctg cttccggtcg gcggatttgt tcgtatggcc ggcgaagatc cggaaatgat 1603861 tgaggtgaaa cccggataca cggtcgggct tctgtttaat aaggaagatc aagttgagaa 1603921 agtcatcatc aatcaaaagg aaaaatatcc ggatgcttta gtcattgaag tggaaacagc 1603981 ggatctagag catgacatga agatcaccgg ttatgaacag gggaaagagg acgaactttc 1604041 cagctttact gtcagcgaaa catccttttt tattgtagac ggagaagaag tgcagattgc 1604101 gccgtataat cgccaatttg gttccaaacc tgtatggcag cggattaaag caattgctgc 1604161 agggccgatt atgaacttta ttttagctta cgtcatttta gtgatgcttg ggctgattca 1604221 aggcgtaccg tcaaatgaac ctatgctcgg gcagctgaca gacaatggac gggcggctga 1604281 agcagggcta aaagaagggg attatatcca aagcattaac ggagagaaaa tgaggtcttg 1604341 gactgacatt gtctccgctg taaaagaaaa cccggagaaa gaaatggacg ttgcagtaaa 1604401 aagagataac aaaacgcttc atatttcggt gactccggaa gctgttaaag atgagaacaa 1604461 aaaaacaatc ggacgtttcg gttcctatgc gccgactgaa aaaggcgtac tctcagcggt 1604521 tgcttacggc gcgacatcaa cagttgatgt caccaaagcc attttaacca atctgagcaa 1604581 attagtaaca ggccaattta aactcgatat gctgtcaggt cctgtcggca tatatgacat 1604641 gacagaccaa gtggcgaaaa cagggatcgt gaacttattt cagtttgcgg cgtttttaag 1604701 cattaacctt gggattgtca acctgcttcc gattccggca cttgacggag gaagactgtt 1604761 gtttctattt attgaagcga ttcggggcaa accgattaac agggaaaaag aagcatttgt 1604821 tgtgtttatc ggagtagctt tcttaatgct tcttatgctg gttgtcacat ggaacgatat 1604881 ccagcggctg tttttgtaaa cgaaaagtaa atcaatcaga ggtgcgaaga aatgagacaa 1604941 agcttgacgc ttattcctac gctccgtgaa gttccagctg atgccgaagc aaaaagtcat 1605001 cagcttcttc tgagagcagg atttatcaga cagaatacga gcggggtata cagctatatg 1605061 cctcttgcgt ataaggtgat tcaaaacatt cagcagattg ttcgagagga aatggagaaa 1605121 attgatgccg tagaaatgct catgcccgca ttgcagcagg cagagacatg gcaggaatca 1605181 ggcagatggt atacgtatgg tcccgaactg atgagactaa aagaccgtca tggccgtgaa 1605241 tttgctttag gggcaacgca tgaagaggtt atcacttcgc ttgttcgcga tgaggttaaa 1605301 tcttataagc gtctccctct gactctttat caaattcagt ctaagttcag agatgaaaaa 1605361 cgtcctcgct tcggtttgtt aagaggccgc gaatttatta tgaaggatgc gtactctttc 1605421 catgcatctg cagagagcct ggatgaaacg tatcaaaaaa tgtacgaggc ctattctaat 1605481 atttttgccc gctgcggcat taatgtaaga cctgttatcg ctgattcagg cgcaatggga 1605541 ggaaaggata cgcacgaatt tatggcactt tctgcgatcg gagaggatac gattgcgtat 1605601 tctgatgaat cacagtacgc ggctaatatc gagatggctg aagttcttca ccaggaagtt 1605661 ccttcagatg aagagcctaa agctctagag aaggttcata cgcctaacgt gaaaacaatc 1605721 gaagaactga ctgcgttctt acaggtttcg gctgaagcgt gcattaagtc agtattgttt 1605781 aaagctgatg accgttttgt cttagtgctt gtaagagggg atcatgaagt taacgatatt 1605841 aaagtgaaaa acttgcttca tgcagaagtt gtagagcttg ctacacatga agaggtcatt 1605901 cagcagctcg gaacagagcc aggctttgta ggccctgtcg gtattcatca ggatgtggaa 1605961 gtatatgccg atcaagctgt gaaagcaatg gttaatgctg ttgccggggc aaatgaagga 1606021 gatcatcatt ataaaaatgt caatgtgaat cgtgacgcgc aaattaaaga atttgctgat 1606081 cttcgtttta ttaaagaagg tgatccttca ccagacggca agggaacgat ccgttttgct 1606141 gagggaatcg aagtcggaca agtctttaag ctcggaacac gctattcaga agcgatgaat 1606201 gcgacatatt tagatgaaaa cggacgcgcg cagccaatgc tgatgggctg ttacggaatc 1606261 ggtgtgtcaa gaacgctttc tgctattgct gaacagcatc acgacgaaaa aggcttaata 1606321 tggccaaaaa gcgttgcgcc gtacgatctt catattcttg ctttgaacat gaaaaacgat 1606381 gggcaaagag agcttgctga aaagctgtat gccgatttaa aagcggaagg ctatgaagtg 1606441 ctctatgatg accgtgctga gcgtgccggc gtaaaattcg ctgattcaga tttaatcggc 1606501 cttccaatcc gcatcactgt cggaaaacga gctgacgaag gaatcgtcga agtgaaaatt 1606561 cgtcaaactg gtgagtcaac tgagatttca gtagacgaat tatctgcgtt tatcagcaag 1606621 cagtaatcac cataacgatt tatcaaaaaa catgttaaaa tagaaataat agaaggtacc 1606681 tcattgcctg aggtaccttc acttatgatg tttttaggga gggatactgt cttaatggaa 1606741 cagttatcag taaacagaag gcagtttcaa attcttctgc agcagattaa tatgacagat 1606801 gataccttca tgacatactt tgaacatggc gagattaaaa agctgacaat tcacaaagct 1606861 tctaagtctt ggcattttca ttttcaattt aaatctttgc tgccttttca aatatatgac 1606921 acattaacaa cgaggctgac gcaatcgttt gcccacatag caaaagtgac atcttcaatt 1606981 gaagttcagg atgccgaggt cagtgaaagt atcgttcaag actactggtc acgctgcatt 1607041 gaagaactgc agggcatttc gccgccgatt atcagtcttt taaaccagca aaaaccgaag 1607101 ctgaagggca ataaactgat tgtcaaaacc aaaacagata cagaagcggc tgcgctaaag 1607161 aacaaataca gttccatgat tcaagcagaa taccgtcaat ttggctttcc ggatcttcag 1607221 cttgatgctg aaatatttgt atccgagcaa gaagttcaaa agtttcggga gcaaaagctt 1607281 gcggaagacc aagagcgggc tatgcaggcc ttgattgaaa tggagaagaa agataaagaa 1607341 agtgatgaag accaagcacc atctggtcct cttgttatcg gttatcaaat taaagataac 1607401 gaggaaatcc gaacacttga cagcatcatg gacgaagaac ggagaattac ggtccaaggt 1607461 tatgtgtttg atgtggagac gcgcgagctg aagagcgggc gcacgctgtg tatcttcaaa 1607521 attacagact atacaaatag tattttgatc aaaatgtttg cacgtgaaaa agaagatgcg 1607581 gcgctgatga agtctctgaa aaaaggaatg tgggtaaaag cacgcggaag cattcaaaat 1607641 gatacatttg tcagagacct tgtcatgatc gcaaatgacg taaacgaaat aaaagcaaaa 1607701 acccgtgaag attcagcacc tgaaggagaa aaaagagtgg aattgcatct tcattcccca 1607761 atgagccaaa tggatgctgt tacgggtatc ggaaagcttg tcgaacaggc gaaaaaatgg 1607821 gggcatgagg ccatcgcttt gaccgaccat gctgtcgttc aatccttccc tgatgcgtat 1607881 tctgcggcca aaaagcatgg aattaaaatg atttacggga tggaagcgaa tctcgtggat 1607941 gatggcgtgc caattgctta taatgccgca catcgtctgc tcgaagaaga aacatatgtt 1608001 gtttttgacg ttgagacgac aggattgtct gctgtatacg ataccattat tgagctggct 1608061 gcagtaaaag taaaaggcgg agaaattatt gataaatttg aggcgtttgc gaacccgcat 1608121 cgtccgcttt ccgccacaat catagagctg acagggatca cagatgatat gctacaagac 1608181 gctccggatg tcgtagatgt aataagagat ttcagagaat ggattggcga tgatattctt 1608241 gtcgctcata atgcaagctt tgatatggga ttcttaaatg tagcctataa aaaacttctt 1608301 gaagtcgaaa aagctaaaaa cccagtcatt gatacgcttg aacttggacg ttttctctat 1608361 ccggaattta agaaccaccg gttgaacaca ctttgtaaaa agtttgatat cgagctcaca 1608421 cagcatcacc gtgcgatcta tgatactgag gcaaccgctt atttgcttct gaaaatgctg 1608481 aaagacgcag ctgaaaaagg tattcagtac catgatgagt tgaatgaaaa tatgggtcag 1608541 tccaatgctt atcaaagatc aagaccgtat catgcaacat tacttgccgt gaacagcacg 1608601 ggacttaaaa atttatttaa gcttgtgtca ctttctcata ttcattattt ttacagagtg 1608661 ccgcgtattc cgagatctca gcttgagaaa tacagggaag ggcttctgat cggttctgct 1608721 tgtgacaggg gagaggtttt tgagggaatg atgcaaaaat cgcctgaaga ggtggaagat 1608781 atcgcgtcat tctatgatta ccttgaggtt cagccgcctg aagtgtatcg tcacttgctg 1608841 gagcttgaac tggtccgtga tgaaaaagcg ctgaaagaaa ttattgcgaa tatcacgaag 1608901 ctgggggaaa agcttaataa accggttgtt gctacgggaa atgttcatta cttgaatgat 1608961 gaggataaaa tctacagaaa gattttaata tcctcacaag gcggggcaaa tccgctgaat 1609021 aggcatgaac tgccgaaagt gcatttcaga acgacagacg aaatgcttga agctttttct 1609081 ttcttaggtg aagaaaaagc gaaggagatc gtagtcacca atacccaaaa ggttgcttct 1609141 ttagttgatg acatcaagcc gattaaagat gatttatata cgccgaaaat cgaaggcgct 1609201 gatgaagaga tcagagaaat gagctatcag cgtgcaagaa gcatttacgg ggaagagctg 1609261 cctgaaattg tcgaagcgcg gattgaaaaa gagttaaaga gtattattgg ccacggattt 1609321 gctgttattt acttgatctc tcacaaactt gtaaaacgtt cactagatga cgggtatctc 1609381 gttggttccc gtggttccgt aggatcttca ttagttgcga cacttactga gattactgag 1609441 gtaaacccgc tgccgccgca ctatgtttgt cctgagtgcc agcattctga gttctttaat 1609501 gacggttctg tcggttctgg ttttgacctg cctgacaaga catgccctca ttgcggaacg 1609561 cctttgaaaa aagacggcca tgatattcca tttgaaacgt tcttaggatt taaaggggac 1609621 aaagtacctg atatcgattt gaacttctca ggggaatatc agccgcaagc acacaattac 1609681 acaaaagtat tgttcggaga agacaatgta tatcgtgcgg gaacaatagg cacggtggca 1609741 gaaaaaacag cctacggtta tgtaaaaggc tatgccggag acaacaatct tcatatgcgc 1609801 ggtgccgaaa tagatcggct cgtacaggga tgcacaggtg taaaacgtac aactggacag 1609861 caccctggcg gtattatcgt agttccggat tatatggata tttatgattt ttcaccgatc 1609921 cagttcccgg cagatgccac aggttcagag tggaaaacga ctcattttga tttccactcc 1609981 atccatgaca acctgttaaa acttgatatt ctcggacacg atgacccgac tgttattcgg 1610041 atgcttcaag acttaagcgg aatagatccg aaaacaattc cgacggatga tcctgaagtg 1610101 atgaagatct tccagggaac cgaatcactc ggtgtgactg aagaacagat tggctgtaaa 1610161 acgggcactc ttggaattcc tgaattcgga acccgatttg tccggcagat gcttgaagat 1610221 acaaagccga ccactttttc tgagctcgtt cagatttcag gcttgtctca cggaactgat 1610281 gtatggcttg gcaatgcaca ggagctcatc cacaataata tttgtgagct gagtgaggtt 1610341 atcggctgcc gtgatgacat tatggtttat ttaatctatc aaggccttga gccgtccctt 1610401 gcctttaaaa tcatggaatt cgtgcgtaaa ggaaaaggat taacgcctga atgggaagaa 1610461 gaaatgaaaa ataacaatgt cccagactgg tatattgatt cctgtaaaaa gattaaatac 1610521 atgttcccga aagcccacgc cgcggcatat gtcttaatgg cagtccgcat tgcttacttt 1610581 aaagtgcatc atgctctttt gtattatgcg gcttatttta ccgttcgtgc agatgacttt 1610641 gatattgata caatgatcaa gggctctaca gcaatcagag cggtaatgga ggatataaac 1610701 gctaaaggac ttgatgcttc accgaaggaa aagaaccttc tgactgtttt agaattagcg 1610761 cttgagatgt gtgagagagg ctattcattc caaaaagtcg atttatatcg ctccagcgcc 1610821 acagagttta ttattgacgg caacagtctt attccgccgt ttaactctat tccagggtta 1610881 gggacgaacg ctgctttgaa cattgtaaaa gctcgcgaag aaggcgaatt cctctcaaaa 1610941 gaagatttgc aaaagagagg gaaagtatca aaaacgattt tagagtactt agatcgccat 1611001 ggctgtctgg agtcactgcc tgatcaaaac caattgtcac tgttctaata tggaaagcag 1611061 aatttctcag aaattctgct tctatgcata cataagcgca aaaagtgcca tcgtaatatt 1611121 agagtttctg tcacttgctt aggtatgaag gtaagcgtat atccatttgc aataaaaata 1611181 tggttatggt atagttttat tggaaatgct aacgattacc gaggcaaaga gtggggaaac 1611241 ccgctctttt gtattgaaca ggagaatttt gtctcgacat gttcatcgtt tactttttag 1611301 cccctgctct tttgaagcag ggtttttatg cagagtgacg agacgaatat gagatcgaca 1611361 gcacaaggag gaagaacatg agcaaaaaag tgactgacac cgttcaagaa atggctcagc 1611421 caatcgtaga cagccttcag ctggaactcg ttgacattga atttgtcaaa gagggccaaa 1611481 gctggttcct tcgcgtgttt attgattccg atgacggtgt ggatattgag gaatgtgcca 1611541 aagtaagcga agctttaagc gaaaagcttg atgaggcaga cccaatcagc caaaattact 1611601 ttcttgaagt ctcatctcca ggagctgagc gtccgctaaa gaaaaaagcc gatttcgaaa 1611661 aatcactagg aaaaaacgta tacattaaga cgtatgagcc tattgacggc gtaaaagtgt 1611721 ttgaaggtga actggctgaa tttgatggac aaacagtgac agttgagatc acgatcaaaa 1611781 caagaaagaa acggatcaat attccgtatg aaaagatagc taatgcaaga ttagctgtta 1611841 cattctaatg aatacaaatg ttttaagggg ggagaccgtt aaatgagcag tgaattatta 1611901 gatgctctca cgattcttga aaaagaaaaa ggcatcagta aagaaattat catcgaagca 1611961 atcgaagctg cgttaatttc tgcttataag cggaatttta atcaagcgca aaatgtacgg 1612021 gtggatctaa accgtgaaac tggctccatc cgtgtatttg caagaaaaga tgtcgttgac 1612081 gaagtatacg accagagatt agaaatctca attgaagagg cacagggcat ccatccggaa 1612141 tatatggtcg gcgatgtcgt cgaaatcgaa gttacaccta aggatttcgg gcgcatagct 1612201 gctcaaacag cgaagcaggt cgtcacacag cgtgtgcgcg aagctgagcg cggtgtgatt 1612261 tattctgaat ttatcgaccg tgaagaagac atcatgacag ggatcgtcca gcgtctggac 1612321 aataaattta tctacgtgtc tttaggcaaa atagaagcct tgctgccggt taatgagcaa 1612381 atgccgaatg aaagctacaa gccccatgac cgcattaagg tatatatcac aaaagtagaa 1612441 aaaacaacga agggtccgca gatttatgtg tcaagaacac atccaggcct gttaaagcgt 1612501 ttgtttgaaa ttgaagtgcc tgaaatttat gatggaactg tcgagctaaa atctgttgcc 1612561 agagaagccg gcgaccgttc gaaaatttct gttcgcacag atgatcctga cgttgatcct 1612621 gtcggttcat gcgtagggcc taaaggccag cgtgtgcaag caatcgtcaa tgaattaaaa 1612681 ggtgaaaaaa ttgacattgt caactggtcc agtgatcctg tagaatttgt cgcgaatgcg 1612741 ctcagccctt ccaaagtgct tgatgtcatt gttaatgaag aagaaaaagc gacaactgtt 1612801 attgttcctg attaccagct gtctctggca attggaaaaa gaggacaaaa cgcacgctta 1612861 gctgctaaac tgacaggctg gaagattgat attaagagcg aaacggacgc aagagaactt 1612921 ggaatctatc cgagagaact tgaagaagat gatgagccgc tctttacgga gcctgaaact 1612981 gctgaatcgg atgaataaga ggtgacttta ggtgaataaa cacaaaaaga tcccattacg 1613041 caaatgtgta gtgactggtg aaatgaagcc taaaaaggaa ctgatccgag ttgtacggtc 1613101 gaaagaaggc gaaatctcag tagacccgac cggaaaaaag aatgggcggg gtgcttattt 1613161 aacgctggat aaagagtgca tcttagcagc aaaaaagaaa aacactttgc aaaatcaatt 1613221 tcaatcacaa atcgatgacc agattttcga tgaattgctg gaactggcgg aaaaggtgaa 1613281 aaaataaaat gtctggaatg gaatggtttc ccttgctggg tctggccaat cgagctcgta 1613341 aggtcgtgtc aggcgaagac ttggtaataa aagaaatcag gaatgcgcgt gcaaagcttg 1613401 tcctgcttac agaggatgca tcatctaaca cagcaaaaaa agtaactgac aagtgcaatt 1613461 attataaagt cccttataaa aaagtcgaga gtcgcgcggt tcttggacgc tctatcggta 1613521 aagaagcccg tgtcgttgtc gccgtcactg accaaggttt tgcgaataag ctgatcagct 1613581 tgctcgatta atatttttgg gggtgaacga atggctaaaa tgagagtata cgaatatgca 1613641 aaagcgttaa atgtttcaag taaggaaatt ttgaccgcac tgaagaacat ggatttagaa 1613701 gtgaataatc acatggccat gcttgaagaa aaggccatta aaaagctaga tgccaaatat 1613761 aaaaaaggcg gcgcagctgc taaatctcaa aagccagcag aaacgaacaa aaacaaacag 1613821 ccacaagggg ttaatcagca atcagctgga aatcaaccaa ataaaattcg agacggaaag 1613881 aagaatgacg tgcagaataa tcaatttaac aaaaacaaga agaataacaa caacaaaaaa 1613941 aataaacgca acaacaacaa taataaaaac caacatcagc aaaagcctgt aaagccgaaa 1614001 aaagagcttc ctgagaaaat tacattctct ggcactttaa cagttggcgc acttgctgaa 1614061 gagcttggca aagagccttc agaactcatt aaaaagctga tgcttcttgg cgtaatggca 1614121 accattaacc aagagcttga taaagacaca atcgaactca ttgcatcaga atatggtgtt 1614181 gaaacagaag aggtcattgt gcttgaagaa acagagctgg aaaaatacga agagcctgat 1614241 aatgaagagg atcttgaaat tcgtcctcct gtcgtgacaa tcatgggcca cgttgaccat 1614301 gggaaaacaa cgcttcttga cagcatccgt aaaacaaagg ttgttgaagg ggaagcaggc 1614361 ggaatcactc agcatatcgg cgcttatcaa attgaagaga acggcaagaa aatcacgttc 1614421 ttggatacac cgggccacgc cgcatttaca acaatgcgcg cacgcggtgc agaagtaact 1614481 gatattacga ttcttgtcgt agctgccgat gacggtgtca tgccgcaaac agttgaagcg 1614541 attaaccatg caaaagcagc agaggttcca atcatcgttg ctgtgaataa aatagataaa 1614601 gaatccgcaa accctgaccg tgtaatgcaa gaactgacgg aatacggact tgtccctgaa 1614661 gcttggggcg gagaaaccat ttttgtgccg ctttccgctt taactggaaa aggcattgat 1614721 gagctcgttg aaatgatttt gcttgtcagt gaggtagagg aactgaaagc gaatccgaat 1614781 cgtcaggcaa aaggaacggt tattgaagct gaactcgata aaggcagagg gtcagtcgcg 1614841 acgttgctcg tacagactgg aacactgcat gtcggtgatc cgatcgtagt cggcaataca 1614901 tttggccgtg tccgtgcaat ggtcaacgac attggccgcc gtgtgaaaac tgccggcccg 1614961 tcaactccgg ttgaaattac cggtttgaat gatgtccctc aagcgggaga ccaattcctt 1615021 gtctttaagg atgaaaaaac agctcgttct gtcggtgaag cccgtgcttc gaaacagctt 1615081 gaagagcagc gcagcgataa agcgaagctc agtcttgatg atttatttga gcaaattaag 1615141 caaggtgatg taaaagacat caacctcatc gtaaaagctg acgttcaagg atctgctgaa 1615201 gctttaacgg ctgcacttca aaaaattgaa gtagaaggcg ttaaagtgaa aatcatccat 1615261 acaggcgttg gtgcgattac tgaatcagac attatcttgg catctgcttc caatgcaatt 1615321 gttatcgggt ttaatgtgag accggacgga aatgctaaga gtacggctga agctgaaaat 1615381 gtagatattc gacttcaccg tatcatttac aaagtaatcg acgagattga agctgccatg 1615441 aaaggtatgc ttgatcctga atatgaagaa aaagtaattg gtcaagtaga agtacgccaa 1615501 acattcaaag tatctaaaat cggtacaatt gccggcggat atgttactga aggaaccatt 1615561 acgcgcgaca gcggcctccg tttaattcgt gacggcgtcg tcatctttga aggcgaagta 1615621 gatgttctga aacgctttaa agacgatgtg aaagaagttt cacaaggcta tgaatgtggt 1615681 attacaatta agaaatacaa tgacattcgt gaaggtgaca tccttgaagc gtttgtcatg 1615741 caagaaattg aaagaacgtg atcggatttg cggagtgtga atgcatcatt tatgatgcag 1615801 gatcgctaaa agaaaagcgt gccgttctga agcggatttt aaccagggtt caaaacaagt 1615861 tcaatgtttc gatttcggag attggctatc aggacacctg gcaaagaacc agcttcggaa 1615921 tcgccgctgt ttcttcctct cgcgttcaaa cagaaaaaga actgcagcgc gtcctagcgt 1615981 ttatcgattc ttttcctgaa attgaacgga cgatcactag gacagagtgg ttttaactta 1616041 gaggtgattg aattgagtat gagagcaaac cgtgtcggcg agcaaatgaa aaaagaactc 1616101 ggtgatatta tcagccgcaa gctgaaagac ccgagaattg gttttctgac agtaacggat 1616161 gtacgtgtat caggtgattt gcaaattgca aaggtgtata tctcggttct cggtgacgag 1616221 aaaaaacggg aagaagcgct gaaagggctg gcaaaagcga aaggatttat ccgatccgaa 1616281 atcggcagcc gcatcagact tcgaaaaacg cctgaaattg aatttgagtt cgatgaatca 1616341 atcgattacg ggaatcggat cgaaacactg attcacgaat tacattcaga gaaaccatct 1616401 gaataaaaaa agagaggata ggcgtatatc gtctgtcctc tttcttcgtt tataagaaaa 1616461 aaactcaaaa gaaggagtga aaggcaaatg gttaacggag ttctcctttt acataaacct 1616521 gttggcatga catcgcacga ctgtgtcatg aagatccgaa agctgttaaa aacaaaaaaa 1616581 gtaggacata caggaacgct cgatccggaa gtatcaggcg tgcttccgat ttgtgtagga 1616641 agagcgacaa aaatagtcga atacttaact gaaaaatcta aaacgtatga tgcagaaata 1616701 acattgggct tttcaaccac aacagaggat caaaccggag aaacggtgga aacaaagcct 1616761 gtcaatcacg acattgataa agcggatgta gaaaaggttt taaacagttt aaaggggaaa 1616821 caagaacaaa ttccgcccat gtattccgct gtaaaagtaa acggcaaaaa attatacgaa 1616881 tacgcaagag cagggattga agtagaacgt ccgaaacgta tgataaccat tgaagacatt 1616941 gccctgacaa cagagattaa acatcatgga gaaaccgcaa gcttccggtt tacagtgact 1617001 tgctccaaag ggacctatgt aaggacgctg gcggtcatga tcggagaaaa gctcggatat 1617061 ccggcccata tgtctcattt aatccgtacg gcatccggag atttttctct cgacgaatgc 1617121 tttacttttg atgaactcga agcacaggcc caatccggaa ccgtggaaga gcatacagtt 1617181 cctattgaac gtgcgctcaa tcatttgccg aaatggatca taagtgatac attagctaag 1617241 aaagtagaaa atggggcttt gcttgagacg cccgagcagt tttctgaaat gacaagtgga 1617301 gaccgtattg ccgtctttac tgaatccgga acctgcttgg cgatctattt ccctcatcct 1617361 gcaaaaaaag ggctgttaaa gccggcaaaa gtattgatgc aaaaaagcga acaatagaaa 1617421 aaaggtgacc gttctgtgaa gacgatacat attacacatc ctcatcattt aataaaagag 1617481 gagcaggcaa aatcagtgat ggcgttaggt tattttgacg gcgttcatct cgggcatcaa 1617541 aaggtaatcg gcacagcgaa gcaaatagcc gaagaaaaag gtctgacatt agctgtgatg 1617601 acctttcatc cccatccttc tcacgtgttg ggcagagata aggaaccaaa ggatctgatt 1617661 acgcctcttg aagacaaaat aaaccaaatt gaacaattag gcacagaagt tctgtatgtc 1617721 gttaaattta atgaagtgtt tgcttctctt tctcctaagc agtttataga ccagtatatt 1617781 atcggcctta atgtgcagca cgcagtggca ggctttgact ttacgtacgg caaatacggc 1617841 aagggaacaa tgaagaccat gccggatgat ttagacggaa aagctgggtg cacaatggta 1617901 gaaaaattaa cggagcagga taaaaaaatc agttcttcgt atatccgtac cgcgcttcaa 1617961 aacggagatg ttgaattggc gaatgtcttg cttggacaac cttattttat taaaggaatt 1618021 gtcattcatg gtgataaaag agggcggacc atcgggtttc cgacagcgaa tgtcggttta 1618081 aataacagct atatcgttcc gcccacaggt gtatatgccg taaaagcgga agtgaacggc 1618141 gaagtttaca atggcgtttg caatattggc tataagccaa cgttttatga aaagcgccct 1618201 gaacagcctt ccatcgaggt caatctgttt gatttcaatc aagaggtata tggagccgct 1618261 ataaaaatcg aatggtacaa acggattcgg agcgagcgga aattcaatgg catcaaagaa 1618321 ttaactgagc aaattgagaa agataagcag gaagccatcc gttatttcag caatttgcgg 1618381 aaataacttg caacgcacgc aaattttatt ctaaaatatt tgcatatagg cacgattttt 1618441 agtatgatag ttttcgtagt cttaaaacca ttgcttggca atccgaagtc accgacggtt 1618501 gctaggtaac tggggctaaa tatgatttgg aggtgaaaca ggatggcaat tactcaagag 1618561 cgtaaaaacc aactcatcaa tgagttcaaa acacacgaat ctgatactgg atctccagaa 1618621 gttcagatcg ctatcctaac tgactcaatt aacaacttga acgagcattt acgtactcac 1618681 aagaaagacc accactcacg tcgcggtctt cttaaaatgg taggtaagcg tcgtaatctt 1618741 cttacgtatc tgcgtaataa agacgtaact cgttaccgtg agttaattaa caaactaggc 1618801 ttacgtcgat aatcgtaaaa agcgggagga ttcccgcttt tttatcgtat taaagcgaaa 1618861 tttcttataa caaatcattg aaatcctttt acatactact ttgacattga tatgttcaat 1618921 tcatttcgtt cataatagga gtaattgatt atttcacaca acgaagagag gagttcgtaa 1618981 ttgtatggga caagaaaaac atgtctttac catagattgg gccggaagaa cgcttaccgt 1619041 tgaaaccggc cagcttgcca aacaggcaaa tggtgctgtg atgatccgct acggtgatac 1619101 agcagtactt agtacagcaa ccgcttcaaa agaacctaaa ccgcttgatt tcttccctct 1619161 tactgtaaac tatgaagaaa gattatatgc ggtagggaaa attccgggcg gatttattaa 1619221 aagagaagga cgtccaagtg aaaaagcggt tcttgccagc cgtttaattg accgtccgat 1619281 ccgtcctttg tttgccgatg gattccgtaa tgaagttcaa gtcatcagca ttgtcatgag 1619341 tgttgaccaa aactgctctt cagaaatggc tgccatgttc ggttcatctc ttgcactttc 1619401 tgtatcggat attccgtttg aaggaccgat tgcaggggtt actgtcggac gcattgatga 1619461 tcaatttatc attaacccga cagtcgatca gcttgaaaaa agcgatatca atcttgtcgt 1619521 tgccggcacg aaagatgcga ttaacatggt agaagcggga gcggacgaag ttcctgagga 1619581 aatcatgctt gaggccatta tgttcggcca tgaagagatt aaacgcctga ttgcattcca 1619641 agaagaaatt gttgcagcag tcggcaaaga gaaatctgaa attaagctct ttgaaattga 1619701 tgaagagctt aatgaaaaag taaaagcttt ggcagaagag gatctgctga aagccatcca 1619761 agttcatgaa aagcatgccc gtgaagatgc cattaacgaa gtgaagaacg cagttgtggc 1619821 aaaattcgag gatgaagaac atgatgaaga cacaatcaag caagtgaagc agattttatc 1619881 caagcttgtg aaaaatgaag ttcgccgcct gattactgaa gagaaagtaa gaccggacgg 1619941 ccgcggtgtc gatcaaatcc gtccgctctc ttcagaggtt ggcctcttgc caagaacgca 1620001 cggttcaggt ctatttacaa ggggacaaac tcaggccctc agcgtatgta cgctaggtgc 1620061 tctgggagat gtgcaaatcc ttgacggctt aggtgtcgaa gagtcgaaac ggtttatgca 1620121 tcattacaac ttcccgcaat tcagcgttgg ggaaacagga ccgatgcgcg gaccgggacg 1620181 tcgtgaaatc ggacacggag cactgggtga gcgtgcgctt gagccagtta ttccgtctga 1620241 aaaagacttc ccttatactg tccgtcttgt ttcagaagtg cttgaatcaa acggttctac 1620301 atctcaagca agcatttgcg caagcacact tgcaatgatg gatgccggtg taccgattaa 1620361 agcgccagtt gctggtattg cgatgggtct tgtcaaatca ggcgaacatt acactgtctt 1620421 gactgacatc caaggcatgg aagacgcgct cggagatatg gactttaaag tagcgggaac 1620481 tgaaaaaggc gtaacggccc tgcaaatgga cattaaaatt gaaggccttt ccagagagat 1620541 tcttgaagaa gcgcttcagc aggcgaaaaa gggcagaatg gaaatcctca acagcatgct 1620601 tgcaacatta agcgaatcaa gaaaagagct ttctcgatat gcgcctaaga tcttaacaat 1620661 gaccattaat cctgataaaa tccgcgatgt catcggacca agcgggaaac aaatcaataa 1620721 gatcatcgaa gaaaccggtg ttaaaattga tattgagcag gacggcacaa tctttatttc 1620781 ctctacagat gaaagcggca accaaaaagc gaaaaaaatc atcgaagacc ttgtgagaga 1620841 ggttgaagtc ggccaacttt acctaggtaa agtgaaacgg attgaaaaat tcggggcttt 1620901 cgttgaaatt ttcagcggaa aagacggttt ggtgcacatt tcagagcttg cgcttgaacg 1620961 cgtagggaaa gttgaagatg ttgtgaaaat cggagacgag attcttgtca aagtcactga 1621021 aattgataaa caaggacgag tgaatttatc ccgcaaagcg gtgctccgtg aagagaaaga 1621081 aaaagaagaa caacaatctt aaatgaaaac ataaaaggag cctgggagac ccggcttctt 1621141 tattttgaag cttttcaaaa gcaggcgggt tctaccttgt ccttctcctt cataatgtga 1621201 ggtgaggggg ggacagaaca tgtacaaaaa atttgtaccg tttgccgttt ttttatttct 1621261 tttttttgtc tcatttgaga tgatggaaaa tccgcatgca cttgattata taggggcaat 1621321 gaaaaaagat acggtgactg tcacggcgtc aaaagacccg ttatatgaag aattgcttca 1621381 aaaagcgccg gagtacgaag ttaagcccca gaatgcaaga attgataaag tgtggaaaag 1621441 cattccaggc tacaatggat taaaggtcaa tattgaacaa tcatataaaa aaatgaaaca 1621501 gcatggtaag tttcgggaaa aagatttggt gtacagtcaa gtaaaaccaa gtgttcatct 1621561 tgagtcactt cagcctgagc ctatttataa aggaaatcct gacaaaccga tggtggcttt 1621621 tttaatcaat gtggcatggg gaaatgagta tttggaaaaa atgcttccta ttctgcaaaa 1621681 gcaccaggtt aaagctacgt tctttttaga aggcaattgg gtgagaaaca atgtacagct 1621741 cgctaagaag attgcaaaag acggacatga aatcggaaat cattcataca atcatccgga 1621801 tatgagcaaa ctgactacag gaagaatttc cgagcagctc gacaagacta atgaacaaat 1621861 agaacaaacg atcggcgtta agccaaagtg gttcgctccg ccaagcggaa gtttcagaaa 1621921 agcggttatc gacattgcag cagagaaaca gatgggaaca gtcatgtgga cagttgatac 1621981 aatcgattgg caaaagccgg ctccgtctgt acttcagacg agagtgttaa gcaagataca 1622041 taatggtgcc atgattttaa tgcatccgac tgaccctacg gcggaaagtc ttgaagcgct 1622101 gattacacag ataaaagaca aaggatatgc gcttggaaca gtcactgaac taatggatga 1622161 aacaagacta ttgaagtaac agatgaaggc agcttgtctt tgaataggag gaacaaattt 1622221 gattaaacga tatacgtgtc aaaatggtgt aagaattgtg ctggaaaata acccgacagt 1622281 ccgttctgtt gcgatcggcg tatggatcgg cacaggttcg agacatgaaa cgccggagat 1622341 aaacggaatt tctcactttt tagagcacat gttctttaaa gggacgagca caaaatctgc 1622401 acgcgagata gcagaatctt ttgatcgtat tggcggccag gtcaatgcgt ttacttcaaa 1622461 ggaatatacc tgctactatg caaaggtgct tgacgagcat gcgaattacg cgctggacgt 1622521 attagcagat atgttctttc attcaacgtt tgatgaaaac gagctgaaaa aagagaaaaa 1622581 tgtagtatat gaagaaatta aaatgtatga agatgcgccg gacgacattg tacatgattt 1622641 attgagcaaa gccacttacg gcaatcattc tttaggctac ccaattttag gaacggaaga 1622701 aacgcttgct tcctttaacg gtgactctct cagacaatac atgcatgatt attatacgcc 1622761 ggaccgagtg gtgatttcgg tagcgggcaa tatatctgac agttttatca aagatgtaga 1622821 aaaatggttc gggtcatacg aggcgaaagg caaagcgaca ggccttgaga agcctgagtt 1622881 ccacacggaa aaactgacga gaaaaaaaga aacagagcag gctcatttgt gccttggatt 1622941 taaaggctta gaggttggcc atgaacgtat ttatgattta atcgtcctca acaatgtgct 1623001 cggaggcagc atgagcagcc ggctgttcca agatgtgcgt gaagataaag gacttgctta 1623061 ttctgtttac agctatcaca gctcatatga ggacagcgga atgctaacga tttacggcgg 1623121 aacgggtgca aatcagcttc agcagctgtc ggaaacaatt caagaaaccc tggccacatt 1623181 aaaacgtgac ggcattacct cgaaagaact ggaaaacagc aaagagcaaa tgaagggaag 1623241 cttaatgctg agcttagaaa gcacaaacag caaaatgagc cgaaacggaa aaaatgaact 1623301 gctgctcggc aaacataaaa cattagatga aattatcaat gaattaaacg ccgtgaactt 1623361 agagcgtgtt aatggccttg ccagacaatt gtttaccgaa gactatgcat tagcacttat 1623421 cagcccttcc ggcaatatgc cgtcttaaaa aggaaagcct gccccataat ggagcaggca 1623481 ttttttaatc cctttcatca tacatagtac aagggggtga cagacatgcg gctcagtgaa 1623541 ttatcgggaa aggaaattgt agacatcaaa agagctgaac ggctcggagt gctcggccag 1623601 accgatttgg aaatcaatga acaggatgga cagattacag cactcctcat tcccacagtt 1623661 aagtggtttg gtttgagaaa gcaaggtcat gacattcgtg tcccatggca ccatattcaa 1623721 aagatcggtt cagatatgat tatattagat gtacctgagg aaatgcctcc tcgacaagag 1623781 taaatagccc aattgactgt gaagcgggct ctaaagaaaa catctgaaac atcggctgcc 1623841 ggagccgatg tttttttata tggaaaaagc gcatctttta tattcaccgg tatttccttt 1623901 tgatcataag atgaagggga gcttaacaac tagagatcca gtatatacaa agaaggtgaa 1623961 cgtttagaat gttaaccgga ttgaaaattg cagttatcgg cggtgacgca agacagctcg 1624021 aaattataag aaagctcact gaacagcagg ctgacatcta tcttgtcggt tttgaccaat 1624081 tggatcacgg ttttaccggg gcagtaaaat gcaatattga tgaaattcct tttcagcaaa 1624141 tagacagcat cattcttcca gtatccgcga caacaggaga aggtgtcgta tcgactgtat 1624201 tttcgaatga agaagttgtg ttaaaacagg accatcttga cagaacgcct gcacattgtg 1624261 tcattttctc aggaatttct aacgcctatt tagaaaacat tgcagctcag gcaaaaagaa 1624321 aacttgttaa gctgtttgag cgggatgaca ttgcgatata caactctatt ccgacagtag 1624381 aaggaacgat catgctggct attcagcaca cggattatac gatacacgga tcacaggtgg 1624441 ccgttctcgg tctggggcgc accgggatga cgattgcccg tacatttgcc gcgctcgggg 1624501 cgaatgtaaa agtgggggca agaagttcag cgcatctggc acgtatcact gaaatggggc 1624561 tcgttccttt tcataccgat gagctgaaag agcatgtaaa agatatagat atttgcatta 1624621 ataccatacc gagtatgatt ttaaatcaaa cggtactttc tagcatgaca ccaaaaacct 1624681 taatattgga tctggcctca cgtcccgggg gaacggattt taaatatgcc gagaaacaag 1624741 ggattaaagc acttcttgct cccgggcttc cagggattgt cgctcctaaa acagctgggc 1624801 aaatccttgc aaacgtcttg agcaagcttt tggctgaaat acaagctgag gaggggaaat 1624861 aaggatgtcg tcattaaaag gaaaaagaat cgggtttggg ctgaccgggt cgcattgcac 1624921 atatgaagcg gttttcccgc aaattgagga gttggtcaac gaaggagctg aagtccgtcc 1624981 ggttgtcaca tttaatgtaa aatctacaaa tacccgattt ggagagggcg cagaatgggt 1625041 taaaaaaatt gaagacctga ctggatatga ggccattgat tcgattgtaa aggcagaacc 1625101 tcttgggccg aagctgcccc ttgactgcat ggtcattgcg cctttaacag gcaattcaat 1625161 gagcaagctg gcaaatgcca tgacggacag cccggtgctg atggcggcaa aagcgacaat 1625221 ccggaacaat cggcctgtcg ttctgggtat ctcgacaaat gatgctcttg gtttaaacgg 1625281 aacaaattta atgaggctca tgtcaacaaa aaatatcttt tttattccat tcgggcaaga 1625341 tgatccattt aaaaaaccga attcaatggt agccaaaatg gatctgcttc cgcaaacgat 1625401 tgaaaaggca ctcatgcacc agcagcttca gccgattcta gttgagaatt atcagggaaa 1625461 tgactaaatt tacagaaaat ctttcccaaa ctaaaaaatt cggtcatcac ccgcatattc 1625521 tatggtaaaa taaaacgtaa aatcatagtc aaatcaattc aatgaagctg attggcggaa 1625581 ggagttttac agatgggaag aggtttacac gtagctgttg tcggagcgac aggggctgtg 1625641 ggacaacaaa tgcttaaaac acttgaagac agaaactttg aaatggacac acttacattg 1625701 ctatcttcaa aacgctctgc ggggacaaaa gtcacgttta aaggccaaga gctgactgtt 1625761 caggaagctt ctcctgagag ctttgaaggg gtaaatattg ctttgttcag cgccggcgga 1625821 agcgtatcac aagcattggc accagaagct gtaaaacgcg gcgctattgt tatagataat 1625881 acgagtgcgt tccgcatgga tgaaaataca ccgcttgttg tgccagaagt gaatgaggca 1625941 gacttgcatg aacacaacgg cattattgcc aatccaaact gctctacaat ccaaatggtt 1626001 gcggcacttg aaccgatccg caaagcatat ggcttaaaca aggtcatcgt atcaacttac 1626061 caggcagtat caggagcggg taatgaagct gtaaaagagc tttacagcca aacacaggcg 1626121 attttaaata aagaagaaat agagcctgag atcatgcctg taaaaggtga caaaaaacac 1626181 tatcaaatcg ccttcaacgc gattccgcaa atcgataaat tccaagataa cggctatacg 1626241 tttgaggaaa tgaaaatgat aaatgaaacg aaaaaaatca tgcacatgcc tgaccttcaa 1626301 gtagcggcta catgtgtgag actgccaatc caaactgggc actcagagtc cgtctacatc 1626361 gaaatagacc gtgatgacgc tacagttgaa gatattaaaa atctattgaa agaagctccg 1626421 ggcgtgacac ttcaggatga tccaagccag cagctttatc cgatgcctgc tgatgctgtc 1626481 ggcaaaaacg atgtgtttgt aggccgcatc cgcaaagact tggacagagc aaacggtttt 1626541 catttatggg ttgtttctga taacctatta aaaggcgcgg catggaactc tgttcaaatt 1626601 gcagaaagcc tgaaaaaact aaacctcgta taaaagagag aattttctaa agacgaatag 1626661 aagagagtaa ggcgctatca gcctgctctc ttctgttacg tccgaataat ttggagtgaa 1626721 aacagtgaag ataattgttc aaaagttcgg cggaacatca gtaaaagatg ataaaggccg 1626781 caaactggct ttagggcata ttaaagaagc aatcagtgaa ggatataagg ttgtcgttgt 1626841 cgtttcagcg atgggccgaa aaggggaccc gtatgcaaca gattctttgc tcgggctgct 1626901 ttacggcgat cagtcagcga tttctcctag ggagcaggat ttgcttttat cttgcggaga 1626961 gactatttcc tctgtcgtct ttacaagcat gctgcttgat aacggtgtga aagcagctgc 1627021 gctgacaggg gctcaggctg gctttttaac gaatgatcag catactaatg cgaaaatcat 1627081 tgaaatgaaa ccggagcgtt tattcagtgt gctcgccaat catgatgcgg tagtcgtcgc 1627141 aggcttccag ggcgcaactg aaaagggtga tacaacaaca atcggcagag ggggcagcga 1627201 tacgtctgca gccgcactcg gagcagctgt tgatgcggaa tacatcgata ttttcaccga 1627261 tgtagaaggc gtgatgactg ctgacccaag agtggtagaa aatgcaaaac cgcttcctgt 1627321 tgtgacgtat acggaaatct gcaacctggc gtatcagggg gccaaggtca tttctccgcg 1627381 tgctgtggaa atcgcaatgc aggccaaggt tccgatccgc gtccgttcga cttattcgaa 1627441 tgataaaggc acattggtga catcacatca ctcttccaag gtcggcagtg atgtttttga 1627501 aaggctgatt acgggaatcg cccatgtcaa agatgtcacg cagttcaaag tgcctgcgaa 1627561 aatcggccag tataacgttc agactgaagt gttcaaggct atggcaaacg ctggaatcag 1627621 tgtcgatttc tttaacatta cacctagtga aatcgtctat acggtagccg gaaataaaac 1627681 agaaacagct cagcgtattt taatggatat gggctatgat ccaatggtga cgagaaactg 1627741 cgcgaaggta tcggcggtcg gcgcgggcat tatgggtgtt cccggtgtta cgtccaaaat 1627801 tgtatcggct ctttcagaaa aagaaattcc gatccttcag tcggctgaca gccatacgac 1627861 gatatgggtg ctcgtccatg aagcggatat ggttcctgct gtaaacgctt tgcatgaagt 1627921 gtttgaactt tcgaagtaaa tgtgattgaa tcatgatgag gtgaataaaa tgaatttcgg 1627981 aaatgtgtct acagcgatga ttacaccctt tgacaataaa gggaacgtag actttcaaaa 1628041 actgtctaca ctgattgatt acttgttgaa aaacggaacg gattctttag tagtagcggg 1628101 aacaactgga gaatctccga ccctttcaac tgaagaaaaa attgcgcttt ttgaatatac 1628161 ggtaaaagaa gtaaacggac gggtgcccgt tatcgctggt actgggagca acaacacgaa 1628221 agattccatt aagctgacaa aaaaagctga ggaagcgggc gtggacgctg ttatgcttgt 1628281 taccccgtat tacaataaac cttctcaaga aggaatgtac cagcatttta aagcaattgc 1628341 ggcagagaca tctcttccgg ttatgctcta taatgttcct ggccgtacgg ttgcttctct 1628401 tgctcctgaa acgacgatcc gtttggcggc agacattccg aatgtggttg cgattaaaga 1628461 agcgagcgga gacctcgaag cgattacaaa aattattgct gaaacacctg aagacttcta 1628521 tgtctattca ggggatgatg ctctaacgct tccaattctt tcagttggag gtagaggagt 1628581 tgtgtcagtg gcgagccata ttgcaggcac tgatatgcag caaatgatca aaaattatac 1628641 gaatgggcaa acagctaatg cggcactgat tcatcagaaa ctgctgccga ttatgaagga 1628701 actgtttaaa gcgcctaatc ctgctccagt caaaacagcg cttcagctga gaggtcttga 1628761 tgtcggttct gtgcgtctgc ctctagtccc attaactgag gatgaacgtc tgagcttaag 1628821 cagcacgatc agcgaactgt aagaaaattt catacagtga aacaaacgcg gtcattctca 1628881 cattcagctg agtttgaccg tttcttttac atattggttt tccctaaacc ttctgcttta 1628941 tcttgttttc taaatttact ttcagttata ataggaacaa gtgatgatgg acgggtatga 1629001 gactaggagg atatagattt tgaaaaagaa aaatacagaa aacgttagaa ttatcgccct 1629061 tggcggtgtc ggagagattg ggaagaacct ttatgtcatt gaaattgact cagacatatt 1629121 tgtcgttgat gccggcctta tgcatccaga aaacgaaatg ctcggtattg atgtagtgat 1629181 tcctgacata tcatatttga ttgaacgggc tgaccgcgtc aaggcaatct ttttaacgca 1629241 cgggcacgat gaaaatatcg gcggcgtttt ttacttatta aacaagctgt ccgttccagt 1629301 gtacggaaca aaactgacgc ttgcactgtt aagagagaaa ttaaaacaat acggacataa 1629361 ccgaaaaact gatttaagag aaattcactc caaatctgtc attacatttg aatcaacaaa 1629421 ggtatcgttc tttagaacga ttcacagcat tcctgattct gtaggtgtga gctttaaaac 1629481 atcacttgga tctattgtat gcacgggaga cttcaaattt gaccaaacac ctgcacttaa 1629541 tcagacgtgc gacattggcg agatcgccaa gatcggcaat agcggcgtgc tcgctctgct 1629601 ttctgacagt gcaaatgcgg aacggccggg ttacacccct tcggaagcgg ctgtcagcgg 1629661 agaaatttcg gatgcgctgt ataattcaca gaaccgggtg attattgctg ttttcgcatc 1629721 caatattaac cggattcagc aagtcattca tgcagcggct caaaatggca gaaagattgc 1629781 cgtagccgga aaaaatcttc aatctgtcct gcagctggcg agaaagttag gatatattga 1629841 agcagatgat gaattgttta tttctgtaca ggatgtcaaa aaatatccga agcgcgaagt 1629901 ggccattatt acagccggaa gccaaggtga accattagct gctttgacaa gaatggcaaa 1629961 caaagctcac aaacagctga acattgaaga aggggatacg gtggtcattg cgtcaactcc 1630021 gattcccggg caggaactca tttactctaa aacagtagat cttcttgcga gagccggtgc 1630081 acaagtcatc tttgcccaaa agcgtgttca tgtatcaggc cacggctcac aagaagagtt 1630141 aaagctgatg atcaacctgc ttaaaccaaa atatttgatt cctgtaaacg gcgaatacag 1630201 aatgcaaaaa gctcattcaa aaatcgctga agaaaccggc atgaagcgca gtgacatctt 1630261 cttaattgaa aaaggcgacg tcgttgaatt ccgcggccaa aacgtaaaaa ttggggataa 1630321 agttccttac ggcaatattt taattgatgg tttaggtgtc ggtgatatcg gcaatatcgt 1630381 attgagagac cgccgcttgc tttcacagga cggaatttta atcgttgtca ttacacttga 1630441 taaacaaaag aaacatcttg tatcaggacc agaaattatc actcgcggct ttgtttatgt 1630501 aagagagtct gaaggtctta tcgtacaggc tactgagctt gtacggtcca tcgtgacaga 1630561 agcgactgaa acatcaaatg tcgaatggtc aacgctgaag caggcaatgc gggatgcttt 1630621 gaaccaattc ctttatgaaa aaacgaaacg taaaccgatg atcatcccaa ttattatgga 1630681 agtataatga ctgactaaag accggagctg ctccggtctt tattttttgt ccttcaagcc 1630741 gggattgaat gaagtatctt tgttcataat acaaagagaa actcggaaag gatgaaagcg 1630801 agatggatca tcgtatggaa aacacagaag aagagcgtcc tgaaaaaaat gatgcgaagg 1630861 acagcattat gaataaaata cagcagcttg gtgaaacgac gcttccgcag ctgccccaag 1630921 atacaaatat tcattgtctg accattatcg gacaaattga aggccatgtt cagcttcctc 1630981 cgcaaaacaa aacaacaaaa tatgaacatg tcatcccgca gattgtggca attgaacaaa 1631041 atcccaaaat tgaaggcttg ctgatcatat taaatactgt cggaggagat gttgaagctg 1631101 gtcttgccat agcggaaatg cttgcatctt tatcgaaacc gaccgtttct atcgtgcttg 1631161 gcggggggca ttcaatcggc gttccgattg ctgtatcctg tgattacagc tatatcgccg 1631221 aaacagcaac gatgacgatt catccagtta ggctcaccgg gctggtcatc ggggtgccgc 1631281 aaacgtttga atacctggat aagatgcaag aaagagttgt taaatttgtg acaagccatt 1631341 ccaatataac cgaagagaag tttaaagagc taatgttttc aaaaggaaac ttaacacgcg 1631401 atatcggaac aaatgtagtc ggtaaggatg cagttaaata cggattgatc gatcacgcag 1631461 gcggtgtcgg acaggcaatc aataaactga atgagctcat cgatgaagca aggaaagaag 1631521 aaggacggat gattcaatga ttctttatac cgtgatgcct caggaaattg tgtttgcaga 1631581 acagaaccaa gagacaagcg cacatgagca aattgaatat aaaggtgtac cgcttctagt 1631641 cgaaatgaaa gggaatgaag cggaagtcat tcaaatcatg agcaccaatc caatgcattt 1631701 tctgcatccg gacatttcac cgggacaaaa gctgaaatta aacgtataag aatccaaccc 1631761 ttttttaagg gcaaaatatg ctataatagg ggaatcctac agaaaaaacg cagcctgtaa 1631821 acggctgctt tcttcattat gtatgaactt acatttttta acgcagtaag gtgatgagtg 1631881 tggcaaagaa aaaacgaaaa tcaagaaaaa aacaggcgaa acagctcaat ataaaatacg 1631941 agctcaacgg attgctgtgt atagccattt caattatcgc aatcttgcag ctgggggtag 1632001 tcgggcaaac gtttatctat ttgttccgct tttttgctgg agagtggttt attttatgct 1632061 tgttaggttt attggtgtta ggagtctcac tgttttggaa gaaaaaaacc ccaagccttt 1632121 taacgagacg aaaggccggg ttgtactgta ttatcgcaag catattgctg ctttctcacg 1632181 tgcagctatt taaaaatttg acgcacaaag ggtctattga gtctgcaagc gtggtgcgca 1632241 atacgtggga attgttttta atggacatga atggcagctc tgcttcacct gatttaggcg 1632301 gagggatgat cggtgcgctg ctgtttgcgg cttcacactt tttgtttgcg tcgactggtt 1632361 ctcagatcat ggcaattgtc atgattttga tcggaatgat tttagtaaca ggacgctcgc 1632421 tgcaagaaac gctaaaaaag tggatgagcc cgattggacg ttttataaaa gaacaatggt 1632481 tagcatttat tgatgacatg aaatccttca aatcaaatat gcagtcatcg aaaaaaacga 1632541 aagcgccgag caaaaaacaa aaaccggccc gcaaaaaaca gcaaatggaa ccggagcctc 1632601 ctgatgaaga gggggattat gaaacagtat cgcctcttat tcattcagag ccgattatct 1632661 caagcttttc tgatcgtaat gaagaggaag agtctccagt tatagaaaag cgcgccgaac 1632721 ctgtgtcgaa gccgcttcag gacatccaac cggagacagg tgatcaggaa actgtttctg 1632781 ctcctcctat gacctttaca gagctcgaaa ataaggatta cgagatgccg tcactggatt 1632841 tgctggcaga tccgaagcat accggccagc aggctgataa aaagaatatt tatgaaaatg 1632901 cgagaaagct tgaacgcaca ttccaaagct ttggcgtaaa ggcgaaagtc acacaggttc 1632961 atctcggacc ggccgtaaca aaatatgaag tatatcctga tgtcggagtg aaggttagca 1633021 aaattgtcaa tttaagcgat gatttagcgc ttgcgcttgc tgcgaaggat atcaggatcg 1633081 aagcgcctat accaggcaaa tcagcaatcg gaattgaagt tccaaacgca gaagtggcaa 1633141 tggtttcgct gaaagaagtg ctggagtcta aattgaatga cagaccggat gcgaagctgt 1633201 taattggact cggccgcaat atttcaggtg aagctgtatt ggctgagtta aacaagatgc 1633261 cccacctttt ggtcgcaggc gcaaccggta gcgggaaaag tgtctgtgtc aacggcatta 1633321 ttacaagtat tttaatgcgg gcgaaaccgc atgaagtgaa aatgatgatg atcgatccta 1633381 aaatggtaga gctaaatgtc tacaacggga ttccgcattt gcttgctcct gttgtaaccg 1633441 atccgaaaaa agcgtcgcag gctttgaaaa aggttgtcaa tgaaatggag cggcggtacg 1633501 aattattttc tcatacgggt acaagaaata ttgaaggata caatgattat ataaaacgcg 1633561 ccaacaatga agaaggagcg aaacagccag agctgcctta tattgttgtc attgtggacg 1633621 agctagccga tctcatgatg gtcgcttcat ctgatgtgga agattcgatt acgagattgt 1633681 cccaaatggc gcgggctgcc ggcatccatc ttattattgc gacacagcgg ccatcggtgg 1633741 atgttatcac aggggtgatc aaagcgaaca ttccgtcacg aatcgcgttc agcgtatctt 1633801 cacagacgga ttcaaggacc attcttgaca tgggtggcgc tgagaagctt cttggccgcg 1633861 gcgatatgct gtttttacct gtaggggcta acaaacctgt ccgtgtgcag ggagcatttt 1633921 tgtcggatga cgaagtggag aaggtcgtcg accatgtgat tactcagcag aaagcgcaat 1633981 atcaagaaga aatgattcct gaggagacga cggaaactca ttccgaggtt actgatgaac 1634041 tttatgatga agctgttgaa ttaatcgtcg gcatgcagac ggcatctgtt tcaatgctgc 1634101 aaagaagatt cagaattggc tatacgagag cggcgcgcct gattgacgca atggaggaac 1634161 gcggtgttgt cggaccgtat gaaggcagca aacctaggga agtattatta tcaaaagaga 1634221 aatatgatga gctctcttct taatgaaggg agttccgctt tctatagttg tcaataatga 1634281 tattatgtaa actgatcacc tttctattta ttttttcgac aaaacatgat atagttgtcc 1634341 caattgttca ataattttta tcgaaagtgg tttacggagg ggaaacatgt ctacaaaagc 1634401 tgataatcgg cacttgtatt tgaaagtaat tgaacgaatt aaagaggata taaaaaatgg 1634461 gatctacact gagaaggaaa agctgccttc tgaatttgag ctttccaaaa agcttggtgt 1634521 cagcagagcg acgctaagag aagccttgcg gatactggaa gaagagcatg tgattatcag 1634581 aaggcatggt gtaggcactt ttgtccattc taagccgtta tttctttcgg gtattgaaca 1634641 gctgaacagt gtaaccaaga tgatagaaca ggcgaatatg acccctggca cgatttttct 1634701 atcatcacaa gtgcttatgc cgtctgaaga tgatacgaag agatttcact tggcagaagg 1634761 gcaagaactt ttttaccttg aacgagtcag gacagctgac ggacagccga ttgtgtattg 1634821 tatagacaaa attccgatga atattttgcc gaattctttt tctcatcagc aagaatctat 1634881 gtttgacctg ctagagaaaa attcaggctc cgtaatcagc tatgcagtaa ctgatataga 1634941 accgatcggc tatcacgata ccatttctcc agtgcttgaa tgcgatccgg aaacagctct 1635001 tttgctgtta aaacaaaccc attacgatca gcacgataaa ccggtgcttt attctttaaa 1635061 ttattttaga gcggataaat tcagatttca tgttttgcgt aaacgattct aaaaacggac 1635121 gcctgtatgt gtctgttttt ttatttgcac tgattcatgt ttctttgtac atactttcat 1635181 tccggttaac gcaatatata agggatgaca agaaagtgaa tgggtgaaaa tgttgagaga 1635241 gaaaaatgga atgaaaaata ttattgcatt gtcttctgtc ccgcttgtga tgacactcgg 1635301 gaactccatg ctgattcctg ttcttccgat gatggagaaa aagctgtctg tgacttcatt 1635361 tcaagtatct ttaatcatta ctgtatattc agtagtagca attatttgca ttccgattgc 1635421 cggatatttg tcggatcgtt tcgggagaaa aaaaatattg cttccatgcc tcctcattgc 1635481 aggattgggg ggagccgtag ctgcttttgc ctcgacctat atgaaaaatc cttatgctat 1635541 gatcttggcg gggcgggttc ttcaaggcat tggttctgca ggtgccgctc cgattgtcat 1635601 gccgtttatc ggcgacctgt ttaaaggaga cgatgaaaag gtcagcgcgg gtcttggcga 1635661 tattgaaacc gccaacacgt cagggaaggt actgagtccc atacttggag ccttactggc 1635721 ttcttggtat tggtttgtac cgttttggtt tattccgttt ttctgtttga tcagcttttt 1635781 gctcgtattg tttttggtgg ccaagcctga agaagatgaa gatgcgcctg ctgtttctga 1635841 gtttattaag agtgtgaaga aaatttttaa acaggatggt cgctggcttt atacggtctt 1635901 cattatcggg tgtgtcatta tgtttttgtt atttggcgta ttattttatt tatcagatac 1635961 gctggagaac aagtatgcta ttgacggagt agctaaaggc ggattactgg caatcccact 1636021 tttgtttttg tcaaccagtt cttttatagc tggcaaaaag atcggtaaag ataaaggccg 1636081 aatgaaattt tgcgttgtta caggaatgat tctgttaacc ctttcgttta ttgccttgtg 1636141 gtggaaccac agtttttatt ttttatttgt ctttttaagc tttggcggga ttgggattgg 1636201 aatggctctt cctgctttag atgcattgat aaccgaaggg attgaaagtg aacaatgcgg 1636261 aaccatttcc tccttttaca atagcatgcg ctttatagga gtagctctcg gtccacctgt 1636321 ttttgctgca ttaatgtcta atgcaaactg gattattttc atactctcgg cgttttgcag 1636381 catcgtttct ttatttttag tgctctttac tgtagatgct aaaaaaagtg aagaagaaaa 1636441 aaacttaggg acggtctagc cagccgtctt tttttgcgct ttcttgcaca gtttacaact 1636501 gtacctatac agcatgcgga ggttattgtt tccttataaa tcctacagtt gctataatta 1636561 catgaaagag tgtttctgcg gatgctgaaa attggtcata atacatacta attaagaaat 1636621 gaacgaagga ggttccatat gtcatatgtt aatgaactca aatcaaagca cggcggttta 1636681 accgcacaca ttgtaaaaac agaaaaattc aaaaccgtct cgcttatttt taagatgctt 1636741 gcgccgctga caaaggatca agtcaccaaa agagcgcttc tcccgcatgt gcttcttcgc 1636801 ggaacgaaaa gccatccgaa aaccgcagga ttgcgttcat acttggatga gctgtacggc 1636861 acgtcagtat cggctgatct tacgaaaaaa ggagagcggc atgtcattac gttcaggctt 1636921 gaaatcccga atgaaaaata tttaaaagac caaacgccgc ttctcgagaa agggctccag 1636981 cttctcgcag aactcgtctt ttcacctgct ttggagggag acgcttttca gtcacaatat 1637041 gtggctcaag aaaaacggac gcttaagcaa agaatccaag ccgtctatga tgataaaatg 1637101 cgttattcga atttaaggct gatacaggaa atgtgcaaaa atgatcctta cgcgcttcat 1637161 gtcaatggtg aaatcgacga tgtcgatgac attacggcag agcaattata cgaaacatac 1637221 caaagcgcta tccaaaaaga ccagcttgat ctatatgttg ttggcgacgt ggacagtaac 1637281 caggtacaat cggcaattga taagtatttc aaaacagaag agcgcactct tggcatgatt 1637341 gaaaacaatc acgctgatga aaaagttcag ccaaaagaag taattgatga agaggatgtc 1637401 aagcaaggaa aactgaatat cggctaccgc accagcatca cttatacaga tcaggattat 1637461 cctgctttac aagtgtttaa cggattgttc ggcggattct ctcattctaa acttttcatt 1637521 aatgttcggg aaaaagccag tcttgcttac tacgcggctt cgcgtataga aagttttaaa 1637581 ggcttgttaa tggtgatgtc aggcattgaa gtgaaaaatt ttgaacaggc ggtttcgatt 1637641 attgctgagc aattccaggc aatgaaaaat ggcgatttca gtgagcagga tatagcacag 1637701 acaaaggccg ttattcgaaa tcaagtgctg gaaacgattg atacagcata cggtttatct 1637761 gagtttttat atcagcaggc cgctgctcaa gtcgagattc ctatcgaaga ctttcttgcc 1637821 aatattgaga atgtcacaaa agaggatatc attaaagccg gcgaaaagat tcagcttgat 1637881 acgacttatt tcttaaaagg gacggagggt gcatcttgat caaaccaatc gaatatgaac 1637941 agcttcagga gacgctgtat catgaaaaaa tgtccaacgg ccttgatgtt tacgttttgc 1638001 cgaaaaaagg cttcaacaag acatatgcgg tctttacaac aaagtacggc tcgatagata 1638061 accggtttgt ccctttaggt aaaaacgaga tggttcacgt gccggacggg attgctcact 1638121 ttcttgagca caagctgttt gagaaagcgg acggagacgt ttttcaagat ttcagcaaac 1638181 agggggcttc tgccaatgcg tttacgtcat ttacaagaac ggcttacctt ttctcaagca 1638241 catcaaatgt tgaacgcaat ttagagacgc ttatcgattt cgtacaggac ccatatttta 1638301 ctgaaaaaac ggttgaaaag gaaaaaggga ttatcgggca ggagattaat atgtacgacg 1638361 ataaccctga ttggaggctt tacttcgggg tcattgaaaa catgtacaaa gagcatcctg 1638421 tcagaattga catagcggga acagtggaaa gcatttcaca tattacaaaa gaccttcttt 1638481 atgaatgcta tgaaacgttt tatcacccga gtaacatgct ccttttcatt gtcggccctg 1638541 tagatcctga agcgattatt tctcaggtaa gagaaaacca ggggaaaaag ccgtatactg 1638601 atcagccgga gatcaaacga gaagaagtga aagagcaaga agcggttttc cgaaaagaaa 1638661 aagagatcaa aatgaacgtg cagggaccga aatgccttgt tgggctgaaa tccaaaaatc 1638721 cgtttaaatt aggcaaagag ctcttaaagc atgaactttc aatgaactta ttgcttgaag 1638781 ctctttttgg caaaagctct gcccagtatg aatcacttta tgaaaaagga tatattgacg 1638841 aaacgttcag ctttgatttt actgctgaat atgggttcgg ttttgcggcg atcggcggag 1638901 atacgcctga gcctgatcaa ttggctgaag acatttcaag catgcttttg cgcgccggtg 1638961 aactgattac tgctgaaaag attgaacttg ccagaaagaa aaagatcggc acattcttaa 1639021 aagcgctgaa ttcccctgaa tacatcgcca atcaatttac ccgttatgcg ttcttggata 1639081 tgagcctgtt tgatgttgta acggtactcg agcagattac cctcgaggat gtccagaacg 1639141 taatacaaga ggaaatcgct gcagacagac tgactgtctg caaggttgtt cctaaatcat 1639201 aaacaaaaca tccctccagt gtgaggggtg tttttctgcg gaaagaagga aagaggatga 1639261 acaaaacagc actaatcacc ggagcaagcg gcggcattgg caaaagcatc agcgaaaccc 1639321 ttgcagctag aggatacaat ctgctgctgc attacaatac aaatcaaaac gcggcagcgg 1639381 agcttgctga aaaactaagt cagatgtttg gcgtaaatgc ggagatatta caagctgacc 1639441 tgtccgcgca agatggagca gataagctga caagttcaat tgttcagccg attgatgcga 1639501 ttgttttaaa cagcggacga agccattttg ggctgattac ggatgtagat aacgcaacgg 1639561 tccaggaaat ggttcagctt catgtggcga gtccgtatat gctgacgaga aaccttctgc 1639621 caggcatgat tcggaataaa tcgggagcga ttgtggctgt cagctcgatt tggggagaga 1639681 ctggagcatc ctgtgaagtg ttgtacagca tggcaaaagg agctcagcat tcatttgtaa 1639741 aaggattggc taaggagctg gcgccaagcg gaatcagagt aaacgccgta gcgccgggtg 1639801 cagttgatac aaatatgatg aatcaattta ccccggctga aaaagaagag atcgctgatg 1639861 agattccgat cggccggctg gcccggccgc aagaaattgc ggatgcaaca gcttttctcc 1639921 tgtctgaaaa agcgtcatat atcaccggcc aaattctgtc ggtgaatggc ggctggcact 1639981 gctgatccga aaatattcgg tgtatagttt cttttgcgaa ggacacaata atcttgtaac 1640041 ttcacatgaa atggaggaaa caagcatgtc agtattagaa aactgggata gctggaaaaa 1640101 cttccttggc gaccgtctga actatgcgca agataaaggt atgagccagg atacgattac 1640161 agatcttgcg acagaaatcg gcagctactt ggctaatgaa gtggaatcta agaacgagca 1640221 ggaaaaagtg ctggcagatc tttggagtgt agcatcaaaa gatgaacagc acgccattgc 1640281 caatatgatg gttaagcttg ttgaaaataa cagcactcac taggaagaga ggggattttt 1640341 cctctctttt ttatgttttc ctcatcacag caacattctt ctttctaatt agagaaaaat 1640401 gctttatgat aaaggaaggt aaaattttgc cacaatgaag ggggtatatc atttggcaaa 1640461 gctcgaatgg tattttgaat atgaaattca agtgaaccgc cccggactgc tcggggatat 1640521 ttcatctctt cttgggatgc tttctatcaa catcgtaacg ataaacggcg tcgatctttc 1640581 cagaagggga atgctcctca ggtgccgcca tatagatcaa attaaacgat tagaatcaat 1640641 cttaaaaacg atggaaacaa ttaaagtaac gaagcttaga gaaccgaggc ttcgcgaccg 1640701 tcttgccgta cgccacggcc gttatattca acgggatgcc gatgacaaga aaacgttccg 1640761 ctttgaacgg gacgagcttg gcttattagt cgattttatg gccgaattgt tcaaaaaaga 1640821 aggccataaa ttaatcggaa tcagaggtat gccgcgtgtc gggaaaacgg aatcgattgt 1640881 agcctctagt gtgtgcgagc aaaaggtggc tgtttgtgtc atcaaccttg ctgaagcaga 1640941 cgataagaag ccagctgatt gccgatgaat acagcactga aaatgtcttt atcgttgacg 1641001 gaattgtgtc aacacgaaga gggtcagaac gccatctcca gctggtccga gaaatcatgc 1641061 ggctgcctgc aacaaaagtg gtggagcatc cggacatatt cgttcaaaat acagagtata 1641121 cactagatga ctttgattat attattgaac tgagaaatga ccctgatgag gttattacat 1641181 atgaacatgc cgaggaaccc caaatgtttg atcaatccgg gttttcaagc tttgattttt 1641241 aaaattggaa ggtgtttgtt gtgactgaac taggaatccg gctcaaagaa gccagagagg 1641301 aaaaagcaat gtcattggat gatctccaag cggcaacaaa gattcaaaaa aggtatttaa 1641361 ccgccttgga ggaaggaaac tatgacatta ttccggggaa gttttatgtt cgggcattca 1641421 tcaagcaata tgcagaagcc gttgggcttg atgcggatca gctgtttgag gagcataaaa 1641481 aagatatccc taatacgtat catgatgatg tgtctgaaaa gatctccggc atgaatcttc 1641541 aaaaggaaat gccaaagcca gcatctaagg cgctggagct gctgccaaca atacttgtta 1641601 ttctcggcgt gattgtcgtg attgccattg tgtacgcgat cattcaattt gccaatcaca 1641661 aaaacagtga tgatcacaat gcggcatcag aaaaagcaat tacgcaaagt gagagcaagt 1641721 acgaaatccc taaagattca acgctgaaag agaatcaaaa taacagctct gaaaaagaga 1641781 cagacactaa aaaagaaacg aaagaaaacg aagataagaa aaaagaaaat gacagtgaga 1641841 agctggagat taaagctgct ggcactgaag gatcgttaac gacttatgaa gtgtccggcg 1641901 ctgataaaat cgagctggaa ctgaaggcat cagacagctc ctggattaga gtgcgcgatg 1641961 aaaacagcag ctctttaaaa gaaggaacgc tgaaaaaaga cgaaacctat aaaaaagaca 1642021 taactgatca gaaacaagtt gatatccgca ccggatatgc acctaatctg aaaataaaaa 1642081 tcaacggtaa ggttctttca tatgaacttg atccgaaaaa agtgatggca caaaccataa 1642141 agattgtaaa taaaaaggaa gaaaagtcat cttaattacc agatgacttt tcttcacgtc 1642201 cgagtatgaa attggagggg ctttatgttt aacttaccaa ataaaatcac actagctaga 1642261 atcgcattaa tcccaatctt catgattatc atgctggcgc cgtttgactg gggcaggctc 1642321 gaagttggag acgaatccat cccggtcgca catttggcgg gggccattct atttattatt 1642381 gcatctacaa cagactgggt ggacgggtat tatgcccgaa aattaaatct cgtaacaaac 1642441 ttcgggaaat ttcttgatcc gcttgcggac aaactgctcg tatccgcagc gttaattatc 1642501 cttgttcaat ttgatctcgc tccagcttgg atggtcattg tgattatcag cagggagttt 1642561 gccgtgacag gtttaaggct tgtcttagcc ggaacaggag aagtcgtagc tgctaacatg 1642621 cttggtaaaa tcaaaacctg ggcacagatt attgcggtat ctgcattgct tcttcataat 1642681 cttccatttg aacttgtgtc attcccgttt gcagacttgg cgctgtgggt agccgtcttc 1642741 tttactgtcg tctcaggctg ggaatatttc tctaaaaatt gggaagcgtt aaaaacatct 1642801 aactaagaaa gaaggacttc gtcatggaat ttccaaaaaa agcagaaata attgcagtcg 1642861 gttcagagtt gctgcttggt caaatcgcca atacaaatgc tcaatttatc agcaaacagc 1642921 tcgctgaaat cggggtcaac gtattttatc atacagcggt cggagataac ccggagcggc 1642981 tgaagcaggt catccgcatt gctgaagaac gctctgactt cattattttt tcaggagggc 1643041 ttggacccac aaaagatgat ctgacgaaag aaacgattgc aaatacgctg ggacgtccgc 1643101 ttgtgttaaa tgatgaggca ttccaatcca ttgaggacta tttcaaacga acaaaacgca 1643161 cgatgtcacc taataaccga aaacaggcgc ttgtgatcga aggctctgac gtgctggcga 1643221 atcactttgg aatggccccg ggaatgctca cagagcatga atcgcgctat tatatgcttc 1643281 ttcctggacc gccgagcgaa ttgcgtccaa tgtttgaaaa cgaggcaaag cctcttctgc 1643341 tgaaaaagat gggttcaaat gaaaaaattg tgtcaactgt tcttcgcttt ttcggtatcg 1643401 gtgaatctca gcttgaagcc gatttggaag atattattga tgcacaaacc aatccgacaa 1643461 ttgcgccttt ggcggctgat ggagaggtga cgctgcgtct gacagccaaa cacgccgatg 1643521 aaaaggaaac agagcgtctg ttaaaagaaa cagaggccgt tatcttagag cgtgtcggtg 1643581 aatttttcta tggttacgat gatacttctc ttgtaaaaga gctatctata gcatgtaagg 1643641 aaaaaggcat aacaatttct gcggcagaaa gctttaccgg agggctgttt tctgaatggc 1643701 tgacggatca tagcggtgcc tcaaaattat ttgccggggg cgttgtttgc tatacaaacg 1643761 acgtgaagca gaatgtgctt ggtgtcaaga aggaaacatt agatcgtttt ggggcggtca 1643821 gcaaggagtg cgcatccgaa ctggctaagg gtgttcaaaa actcactggc agcgatatcg 1643881 gcattagctt tactggtgta gcaggacctg atgctcaaga agggcatgag cctgggcatg 1643941 tgtttatcgg catttccgca aatggtaaag aagaggttca cgagtttcac tttgcgggct 1644001 ccagaacggg gatcagaaaa cgcggcgcta aatacggctg ccatttaatc ttaaagcttt 1644061 tagagcaaaa ataatatttt cagcacatta tcctcctaag aaaacatgat ttctctgata 1644121 cattatgata ttttgatagg aatcacgcca agaaaaaatc cgaatatgcg ttcgcttttt 1644181 tcttggcaaa tcccttcaaa cagggtatag tatatgtagt ggtaacataa aggaggaaaa 1644241 aatagaatga gtgatcgtca ggcagcctta gatatggctc ttaaacaaat agaaaaacag 1644301 ttcggcaaag gttccattat gaaactggga gaaaagacag atacaagaat ttctactgta 1644361 ccaagcggct ccctcgctct tgatacagca ctgggaattg gcggatatcc tcgcggacgg 1644421 attattgaag tatacggtcc tgaaagctca ggtaaaacaa ctgtggcgct tcatgcgatt 1644481 gctgaagttc agcagcaggg cggacaagcc gcgtttatcg atgcggagca tgcgttagat 1644541 ccggtatacg cgcaaaagct cggtgttaac atcgaagagc ttttactgtc tcagcctgac 1644601 acaggcgagc aggcgcttga aattgcggaa gcattggttc gaagcggggc agttgacatt 1644661 gtcgttgtcg actctgtagc cgctctcgtt ccgaaagcgg aaattgaagg cgacatggga 1644721 gattcgcatg tcggtttaca agcacgctta atgtctcaag cgcttcgtaa gctttcaggg 1644781 gccattaaca aatcgaagac aatcgcgatt ttcattaacc aaattcgtga aaaagtcggt 1644841 gttatgttcg ggaacccgga aacaacacct ggcggccgtg cgttgaaatt ctattcttcc 1644901 gtgcgtcttg aagtgcgccg tgctgaacag ctgaaacaag gcaacgacgt aatggggaac 1644961 aaaacgaaaa tcaaagtcgt gaaaaacaag gtggctccgc cgttccgtac agccgaggtt 1645021 gacattatgt acggagaagg catttcaaaa gaaggcgaaa tcattgatct aggaactgaa 1645081 cttgatatcg tgcaaaaaag cggttcatgg tactcttatg aagaagagcg tcttggccaa 1645141 ggccgtgaaa atgcaaaaca attcctgaaa gaaaataaag atatcatgct gatgatccag 1645201 gagcaaattc gcgaacatta cggcttggat aataacggag tagtgcagca gcaagctgaa 1645261 gagacacaag aagaactcga atttgaagaa taaaaataaa ataagtttca aatgatacaa 1645321 aaggctgagt gaaaaactca gcttttttgt attttgcaaa aaaatgataa aaatattgct 1645381 ttttttgaca acttttttag ggctttattc gtctaacaaa acgtgtgcaa aatggaattt 1645441 attttgggag gaaaaaatga atgacaagcc caacccgcag aagaactgcg aaacgcagac 1645501 ggagaaaact aaataaaaga ggaaaactgt tgtttggtct tttagcagtg atggtttgca 1645561 ttacgatttg gaatgctctt catcgaaata gtgaagaaaa cgaaccatct caagaaactg 1645621 cagcggtttc aaataccgat cagaaaaaag aggtcaaaaa gaaaactgcc aaaaaatcag 1645681 aggaacaaat caaaacagtg gatcgaaacc aaaaaatcag caattattta aaagagatcg 1645741 gtttcagcgg aacagccatg attgtcagaa atggagaaat cgtaacaaat aaaggttttg 1645801 gctatgctga ccgtaaacac tacattcaaa ataatccatt gacatctttt tatgtcggtt 1645861 catcacaaaa agcgctgatt gcaactgcta ttttgcagct tgaggaaaag gggaaacttc 1645921 agacaagtga tccggtaagc acgtatttac ctcattttcc caacggacaa acgattactt 1645981 tgaagaatct gcttacacat acatcgggga taaacggaca tattgaagga aacggcgcca 1646041 ttactccgga cgatttaata aaagatatag aacttcaggg aatcaaacgt cagccgggcg 1646101 tatgggacta caaggattcc aactattctg ttcttgctta tattattgct gaagtaagcg 1646161 gtgagcccta tgaacagtac ataaagaatc atatttttaa acctgcggga atgacgcatg 1646221 caggctttta caaaacatat gaaaaagaac cttatcctgc cgtcgggtat aagatggagg 1646281 gcagcaaaac agttacaccg tatatacctg atttatccca gctgtatgga gcgggtgata 1646341 tttatatgag cgctatagat atgtacaaat ttgaccaagc gctgatagac ggaaaactgt 1646401 attcgcaaaa aagctatgaa aagatgttta cgccagggag cagctccaca tacggcatgg 1646461 gattttatgt tgctcccgga agctattcaa accatggtgt tatgccgggc ttcaatatct 1646521 tgaacagctt tagcaaatct gggcaaacca ttgttatttt gttctcaaac attcaaaata 1646581 atgctaaatt gggccaagtg aacaataaaa tataccagct tctaaatcaa gaatgattgg 1646641 cgatcttctt ttggatgaat tgcattcggc acgtgaaaag aagactggcc tgcaaacgtt 1646701 aagatggcaa gcttgacaag tatttccgac acatttacaa tgaagttgta acatttgttt 1646761 ttttaacatg attgttaaac catttaaact tgacaagggc gatgaacaca ctcattccct 1646821 gtgaaggttc tgtatgttga gaaaactaga caatgtacat gccgacactt tttaagcaac 1646881 aaccaagttc atagcaagag gaggtgaaag tatgacccca attatgatgg ttctcatctc 1646941 cattttgctg attctactcg gtttagttgt tggctacttt gttcgtaaaa ccattgccga 1647001 agcgaaaatt gcgggcgcac gcggtgcagc cgagcaaatt cttgaagatg cgaagcgtga 1647061 tgctgaagca ctgaaaaaag aagctctgct tgaagcaaag gatgaaatcc acaaacttcg 1647121 aatagatgct gaacaggaag ttcgtgaaag acgaaatgag cttcaaaaac aagaaaaccg 1647181 tttactccaa aaggaggaaa accttgatcg caaacatgag ggaattgata aacgggaagc 1647241 gatgttggag aagaaagatc attctctgaa tgaacgacaa caacatattg aagagatgga 1647301 aagcaaagtg gatgagatga ttcgtatgca gcagtctgag ttggaacgaa tttcgagtct 1647361 gactcgtgac gaagcgaaac aaatcattct tgagcgggtt gaaaacgagc tttcacatga 1647421 catcgccatc atgacaaaag aaactgaaaa ccgtgcgaaa gaagaggcgg ataagaaagc 1647481 gaaaaacatt ctttcactcg ccttacagcg ctgcgcagcg gaccacgttg ccgaaacaac 1647541 ggtatcagtt gtcaatcttc caaatgatga gatgaaagga cgtatcatcg gacgggaagg 1647601 gcgtaacatt cgtacgcttg aaacgctgac aggaattgac ctgattattg atgatacgcc 1647661 tgaagctgtc attctttccg gatttgatcc gatcagacgt gagacagcca gaattgctct 1647721 tgataaactc gttcaggatg gccgtattca tccggcacgg attgaagaaa tggttgaaaa 1647781 atctcgccgc gaggtcgatg actatattcg tgagatgggt gagcaaacga catttgaggt 1647841 tggcgttcat ggcctccacc cagatctcat caagatcctc ggccgcttaa agttccgtac 1647901 aagctacggt caaaatgtgc ttaagcattc catggaagtc gcattcttgg ccggtctaat 1647961 ggcatcggag cttggtgaag acgcaaagct tgctaaacgt gcgggtcttc ttcacgacat 1648021 cgggaaagca attgaccatg aagtagaagg aagccacgtt gagatcgggg tagagcttgc 1648081 gaccaaatat aaagagcacc cagtcgtgat taacagtatt gcatcacacc acggggacga 1648141 ggagccgact tccattattg ctgtactggt agctgcagca gatgcgcttt ccgctgcaag 1648201 acctggcgca agaagtgaga cgctcgagaa ttatattcga agacttgaaa aacttgaaga 1648261 aatttctgag tcctacgaag gtgttgaaaa atcatttgcc attcaggctg gacgcgaagt 1648321 gcgaattatg gtgaagccgg attcaattaa tgatcttgag gctcatcgac tggcgcgaga 1648381 tatccgcaag cgaattgagg acgagctcga ttatccaggt catattaagg tgacagtaat 1648441 cagagagact cgagccgtag agtatgcaaa ataaagtgat gcgctaagca tcactttatt 1648501 tttttgacgg caaggaattt tcaagaagaa aggatttaca aaatgagaat tttatttatc 1648561 ggagatgttg tcggttcacc gggccgtgac atggtcaaag aatatgtacc aaagctaaaa 1648621 acaaaatata agcctcactt taccattatt aatggtgaaa acgccgcaca tggaaaaggc 1648681 ctgacggaaa aaatttatca cagcttaatc cagtccggcg cagatgcaat cacaatgggg 1648741 aaccacacat gggacaaaaa agaaatattt gattttatag atgacgttcc gaacttggtt 1648801 cgcccggcaa actttcctga aggaacaccg gggaaaggga tcacatatgt gaaagcaaac 1648861 ggcaaagaac tagcagtcat taatttgcag ggacgtacgt ttttgccgcc gcttgatgac 1648921 ccgtttttaa aagcggatga attgatcgca gaagctgcga aaagaacacc gtacattttt 1648981 attgactttc atgccgaagc gacaagtgaa aagctcgcac ttggctggta cacggatgga 1649041 cgggcatcgg ctgtagtagg aactcataca cacgtgcaaa cagcggataa ccgcattttg 1649101 ccgaagggaa cggcatatat tactgatgtg ggaatgactg gcccgtatga cggtatactg 1649161 gggatggaca gagagacgat tattaagcga ttcaaaacga accttccagt ccggtttact 1649221 gtcgctgaag gaaaaacaac gctcagcgga gttgtcattg acattgacga tcaaacgaaa 1649281 aaagccgtga aaattgagcg tattttaatc aacgatgatc acatgttctt tgaatagttg 1649341 aacatatggt tattttataa aaatattaaa aagaaaagca ggaatatagc aactccttag 1649401 tgaatatagt aaaaatggaa ggtagcccgc tatttttgaa aagcattgtg gggatggctt 1649461 tttggatagc aacatctaat aatgattgtt ctaatgaaca ctcacttatc cattgtaaaa 1649521 ctaaggggga gcagaaatgg aaatcttaaa agtttcagca aaatcgagtc caaattcagt 1649581 ggcaggtgcg cttgcaggcg tgttgagaga gcgaggagcc gccgagattc aagcgatcgg 1649641 agcgggtgca ttaaaccagg ctgtaaaagc tgtggcgatt gccaggggat ttgtggcgcc 1649701 aagcggcgtt gatttgattt gtattccggc ttttacagat attcaaatcg atggggaaga 1649761 aagaacagcg attaaattaa tcgtggagcc tcgctaaaaa caaataaagc attctcaacc 1649821 tgtttgcgta atgcaaacag gttgtttttc atttattgtg atattttctc ccgatagtat 1649881 ttttagcaca taaatgagcg aatatacaaa atcagaaatg agctaaaacg tttcaaaaaa 1649941 aatttccgcc catttttcaa gacagatact tttgtccttc tggaaaagac agttctgttt 1650001 acgcttattc catatcatgg tacaatccga atataacaag aatttttcaa ggaggattgt 1650061 acatgcagag tggaaagatg aaagctctaa tgaaaaagga cggggcgttc ggtgctgtgc 1650121 tgactgaagt tcccattcct gagattgata aacatgaagt cctcataaaa gtgaaagccg 1650181 cttccatatg cggcacggat gtccacattt ataattggga tcaatgggca cgtcagagaa 1650241 tcaaaacacc ctatgttttc ggccatgagt tcagcggcat cgtagagggc gtgggagaga 1650301 atgtcagcag tgtaaaagtg ggagagtatg tgtctgcgga aacacacatt gtctgtggtg 1650361 aatgtgtccc ttgcctaaca ggaaaatctc atgtgtgtac caatactgct ataatcggag 1650421 tggacacggc aggctgtttt gcggagtatg taaaagttcc agctgataac atttggagaa 1650481 atcccgctga tatggacccg tcgattgctt ccattcaaga gcctttagga aatgcagttc 1650541 ataccgtact cgagagccag cctgcaggag gaacgactgc agtcattgga tgcggaccga 1650601 ttggtcttat ggctgttgcg gttgcaaaag cagcaggagc ttctcaggtg atagcgattg 1650661 ataagaatga atacaggctg aggcttgcaa aacaaatggg agcgacttgt actgtttcta 1650721 ttgaaaaaga agacccgctc aaaattgtaa gcgctttaac gagtggagaa ggagcagatc 1650781 ttgtttgtga gatgtcgggc catccctcag cgattgccca aggtcttgcg atggctgcga 1650841 atggcggaag atttcatatt ctcagcttgc cggaacatcc ggtgacaatt gatttgacga 1650901 ataaagtggt atttaaaggg cttaccatcc aaggaatcac aggaagaaaa atgttttcaa 1650961 catggcgcca ggtgtctcag ttgatcagtt caaacatgat cgatcttgca cctgttatta 1651021 cccatcagtt tccattagag gagtttgaaa aaggtttcga actgatgaga agcgggcagt 1651081 gcggaaaagt aattttaatt ccataaaggg ggataaacat gacgaaggaa tttgagtttt 1651141 taaaagcaga gcttaatagt atgaaagaaa accatacatg gcaagacata aaacagcttg 1651201 aatctatgca gggcccatct gtcacagtga atcaccaaaa agtcattcag ctatcttcta 1651261 ataattacct cggattcact tcacatccta gactcatcaa cgccgcacag gaggccgttc 1651321 agcagtatgg agccggcacc ggatcagtga gaacgattgc gggtacattt acaatgcatc 1651381 aagagcttga gaaaaagctg gcagccttta aaaaaacgga ggcggcactt gtattccaat 1651441 caggcttcac aacaaaccaa ggcgtacttt caagtattct atcaaaagag gacattgtca 1651501 tctcagatga attgaaccat gcctctatta ttgacggaat tcgactgaca aaggcggata 1651561 aaaaggtgta tcagcacgtc aatatgagtg atttagagcg ggtgctgaga aagtcaatga 1651621 attatcggat gcgtctgatt gtgacagacg gcgtattttc catggatggc aacatagctc 1651681 ctctgcctga tattgtagag ctcgctgaga aatatgacgc atttgtgatg gtggatgacg 1651741 cccatgcatc cggagtactt ggcgaaaacg gcaggggaac ggtgaatcac ttcggtcttg 1651801 acggcagagt gcatattcag gtcggaacat taagcaaggc aatcggagtg ctcggcggct 1651861 acgctgcagg ttcaaaggtg ctgatcgatt atttgcgcca taaaggccgt ccatttttat 1651921 tcagcacatc tcatccgccg gcagtcactg cagcttgtat ggaagcgatt gatgtcttgc 1651981 ttgaagagcc ggagcatatg gagcgcttgt gggagaatac tgcctatttt aaagcaatgc 1652041 ttgtgaaaat gggtctgact ctcacgaaga gtgaaacgcc gattcttcct attttaatag 1652101 gtgatgaagg tgtggcaaag caattttcag atcagctcct ttctcgcggt gtttttgccc 1652161 aaagtatcgt tttcccgact gtagcaaagg gaaaagccag aattcgcacg attataacag 1652221 cagagcacac caaagatgaa ctggatcagg cgcttgatgt catcgaaaag acggcaaagg 1652281 agctccagct attgtaacaa gaggaagagt ttactcttcc tcttttgatt ccttattgat 1652341 tattattctc aatgagtgta caatgatagg ttgccagttg tgcagagctt caataacctt 1652401 tatactgaag ggtggaagtt tggtttgaaa ggagaaaata tgacatgaat gaaaaacaaa 1652461 aattagagag cggacaagtt catccatcgg acaaaaaatc cgagaaggat tacagcaagt 1652521 actttgaagc tgtttacatt ccgccttctt taaaagacgc gaaaaaacga ggcaaggaag 1652581 ccgttactta tcataatgac tttaaaattt ctgaacaatt taaaggattg ggagacggaa 1652641 gaaagttcta tatccgtacg tacggctgcc aaatgaatga acacgataca gaggttatgg 1652701 cagggatctt tatggcgctc ggttacgaag cgacaaactc tgttgacgat gccaatgtca 1652761 ttttgttaaa tacatgtgca atccgtgaaa atgctgaaaa caaggtgttt ggtgagctcg 1652821 ggcacttaaa agcactgaaa aaaaacaatc ccgatctgat tttaggcgtg tgcggctgta 1652881 tgtcccaaga ggaatcagtc gtgaaccgta ttttgaaaaa acatccgttt gtcgatatga 1652941 ttttcggaac gcataacatt catcgcctgc cggagctttt gtcagaagca tacctttcaa 1653001 aagaaatggt tgtagaagtt tggtctaagg aaggggacgt tattgaaaac cttccaaaag 1653061 tccgaaatgg aaaaattaag ggctgggtca atatcatgta cggctgtgac aaattctgta 1653121 cgtattgcat tgtgccttac acacgcggaa aagaaagaag ccgccgccct gaggatatca 1653181 ttcaggaagt gagaaggctc gcaagtgaag gctataagga aattactctg ttaggccaaa 1653241 acgtaaacgc gtatggaaaa gactttgaag atatgacgta cggacttggt gatttgatgg 1653301 atgaactgag aaaaatcgat atcccgagaa tccgttttac aacgagtcat ccgcgcgact 1653361 ttgacgaccg cctcattgaa gtgctggcaa aaggcggaaa tctgcttgat cacattcatc 1653421 ttccggttca atcaggaagc tcagaagttc tcaagctgat ggcccgcaaa tatgacagag 1653481 agcgttacat ggagctggtg cgaaaaatta aagaagcaat gccaaacgct tctttgacaa 1653541 cggacattat cgtcggattt ccaaatgaaa cggacgaaca gtttgaagaa acgctttctc 1653601 tataccgtga agtggagttt gacagcgcct atacgttcat ttactctccg cgtgaaggca 1653661 ctccggctgc taagatgaaa gataatgtac cgatgcgtgt gaaaaaagaa cgcctgcagc 1653721 gtctaaacgc actggtgaat gaaatttctg ctaaaaaaat gaaggaatac gaaggcaagg 1653781 ttgtcgaagt attagttgag ggtgaaagca aaaataaccc tgatattctt gctggctata 1653841 ctgaaaaaag caagcttgtc aatttcaaag ggccgaagga agccatcggc aaaatcgtcc 1653901 gcgtgaaaat ccagcaagcg aaaacatggt cgcttgacgg agaaatggta ggagaagcaa 1653961 tcgaggtgaa atgagatgac gctctactca aaaaaagaca ttgtgcagca ggctcgaaac 1654021 cttgcaaaaa tgatttctga aacagaagag gttgattttt tcaaacgggc tgaagcgcaa 1654081 atcaatgaga atgacaaagt gtccacaatc gttaatcaga ttaaagccct gcaaaagcag 1654141 gctgtcaatc tgaagcatta tgaaaagcat gaagcgctca aacaagtaga agcaaaaatt 1654201 gacgcgctgc aagaagagct tgaagagatt cctgttatcc aggaattcag agactcgcaa 1654261 atggaagtaa atgacctact gcagctcgtt gcacacacca tttccaacca agtcacaaat 1654321 gaaatcatca catcaaccgg aggcgacctg ctgaaagggg aaaccggttc aaaggtgaag 1654381 cattcaaata acagctgttc tctctaaaca cggtgccttt acaggcccgt gtttttttat 1654441 catttgtgcg gttaaaaatg aactaaataa tctatgtacc aaatgttcaa ttggtttttc 1654501 tgtgctcagc cgcgtataaa ctttatcgca cttataagta aagtttctag gcacccctgc 1654561 atacaatgga acagaaactt tgtattttta tattttattt ataaaaatgc acactagaca 1654621 aatgcccagc ataagataac acgaagaaga acaaggaggc atgccggaat gtctgaatac 1654681 agggaaatta ttacgaaggc agtagtagcg aaaggccgaa aattcaccca atgcaccaac 1654741 accatctcgc ctgagaaaaa accgagcagc attttgggtg gttggattat taaccacaag 1654801 tatgacgctg aaaaaattgg aaaaacggta gaaattgaag ggtattatga tataaacgta 1654861 tggtactctt acgcggacaa cacaaagaca gaggttgtca cagaacgggt aaaatatgta 1654921 gatgtcatta aactcagata cagagacaat aattacttag atgatgagca tgaagtgatt 1654981 gccaaagtgc ttcagcagcc aaactgcctt gaagtgacca tttcgccgaa tggaaataaa 1655041 atcgttgtgc aggcagaaag agaatttttg gcggaagtgg taggggaaac aaaggtagtt 1655101 gttgaggtca atcctgactg ggaagaggat gacgaggaag attgggaaga tgagcttgat 1655161 gaagagcttg aagacatcaa cccggagttt ttagtgggag atcctgaaga ataaaaaagg 1655221 gactagggga gacagtaccc ccaagtctct tttttatatt gatatatcat tcttttatca 1655281 ctttttgttt atgttataat gaaggttgga aaatagaaac gttgatacat agtgagggat 1655341 taaacaatgg ccggttatac gcctatgata cagcaatatt taaaaataaa ggcagagcac 1655401 caggatgcct ttttattttt tcgcctgggt gatttttatg aaatgttttt tgaggacgcc 1655461 aaaaaagcgt cacaagagct ggaaattacg ttaacgagca gagacggcgg tgcggctgaa 1655521 aaaataccga tgtgcggtgt gccgtatcat tctgcttccg cgtatatcga acagcttatt 1655581 aaaaaaggat acaaagtggc gatctgtgaa cagacggaag atccgaaagc cgcaaagggc 1655641 gttgtgaaaa gagaagtagt tcagctgatt acgcccggaa ctgtaatgga cggcaaaggc 1655701 atccatgagt cggaaaataa ttttatcgca tctgtttcag cctgctcgaa cggatacgga 1655761 cttgctctgt ctgatttaac aacgggagaa aatttggctg ttttgattga acggcttgaa 1655821 gacgtcatat cagaaattta ttcagtcggc gcacgggaaa tcgtggtttc aggaagcttg 1655881 gatgccgata cagtggcaca gctgagagag cggtgcggtg caacgatttc aattgaagac 1655941 ggagaaacag acgaacacgt aacgatcatt gagcacttaa ataatgaaga tataacaaaa 1656001 acatttctgc gcttatatac gtatttgaaa agaacccaaa agcgcagcct tgatcatctt 1656061 cagcccgtgc aggtgtatga gcttgaggaa gcgatgaaaa ttgacttgta ctcaaagcgt 1656121 aatctggagc tgaccgaaac gattcgttcg aaaaataaaa aaggctccct tttgtggctg 1656181 ctggatgaaa caaaaacggc aatgggaggc cggctactta aacagtggat tgaccggccg 1656241 cttatcagag tcaatcaaat cgaagagcgc caagaaatgg tggaaacatt aatgtcccat 1656301 ttctttgaac gggaagatct gcgtgaacgt ttaaaagaag tatatgactt agaacgcctt 1656361 gccggccgcg ttgcattcgg aaatgtcaat gcccgggatt tgattcagct gaaggaatcg 1656421 ttaaagcaag tgcctggcat caaacagctg gttgcttcac tggctcatga caaggccaag 1656481 gaacgtgcaa agcgcattga cccttgcggg gatgtacttg aactgctgga agaagcgctg 1656541 tacgaaaacc ctcctttatc ggtaaaagaa gggaacctga ttaaagatgg ttataatcaa 1656601 aagcttgatg aatatcgtga tgcaagcaga aacggaaaag actggattgc ccgcctggaa 1656661 cagcaggagc gggaatacac aggcattcgc tctttaaagg tcggctttaa taaagttttc 1656721 ggttattaca ttgaagtgac aaaagcaaac ttgcatttgc ttgaggaagg gcgttatgag 1656781 cggaagcaga cgttaaccaa tgcagagcgc tacattacac ctgaattaaa agaaaaagaa 1656841 gcgctcattt tagaggcgga aaataacatc tgtgagctgg agtacgagct gtttaccgag 1656901 ctgcgcgaga aagtgaagca gtatattccg cggctgcagc agcttgcaaa acagatgagc 1656961 gagctggacg cactgcaatg ctttgcgaca atcagtgaaa atcgccacta cacgaaacca 1657021 gagttctcta aagatgaagt cgaagtgatt gaaggcagac acccggttgt tgaaaaagtc 1657081 atggacagcc aggaatatgt cccgaacaac tgtatgatgg gcgataacag acaaatgctt 1657141 ctcattacag gtccaaacat gtcagggaaa agcacgtata tgagacaaat cgcgctcatt 1657201 tccattatgg cgcaaatcgg ctgctttgta cccgcgaaaa aagcggtgct cccgattttc 1657261 gatcaaattt ttacgcgaat cggcgctgca gatgatttga tttccggaca aagtacattt 1657321 atggtagaaa tgcttgaagc gaaaaatgcg attgtcaatg cgacgaaaaa cagcctcatt 1657381 ctgtttgatg aaatcgggcg gggaacgtcc acttatgacg gcatggcgct ggcacaggcg 1657441 attattgaat atgttcacga tcatatcggc gccaagacgc tgttcagcac acactatcac 1657501 gagctgaccg ttcttgagga caagctgccc cagctgaaaa acgttcatgt tcgcgctgaa 1657561 gaatataacg gaacggttgt ctttcttcat caaattaaag aaggtgcggc tgataaaagc 1657621 tatggtatcc atgtagctca gcttgccgaa ctgccgggag atctgattgc gcgcgctcaa 1657681 gatattttaa aagagcttga gcattcagga aacaaaccgg aagtgccggt gcagaaacct 1657741 caggtgaaag aagagccggc acagctgtcc ttttttgacg aagcggaaaa gccggctgaa 1657801 acaccaaagc tttcaaaaaa agaaaagcaa gtgatcgatg ctttcaaatc acttaatata 1657861 ctggatatga caccgcttga agcgatgaat gaaatgtaca agctgcaaaa gaaattacat 1657921 taaaacgggg tgatgaatgt ggcaaaagtc atccaactgt cagatgagct ttcaaataaa 1657981 atagcggcgg gcgaggttgt ggaacggccc gcctcagtcg tcaaagaatt ggtggaaaat 1658041 gcgatcgacg ctgacagcac agtcattgaa atcgatattg aggaagcagg ccttgcatcc 1658101 attcgggtct tggataacgg cgaaggaatg gagaatgaag attgcaagcg agctttccgg 1658161 cgccacgcaa cgagtaaaat aaaagatgaa aatgatttat tcagggtgag aacgctcggt 1658221 ttcaggggag aagccctgcc gagtatcgcg tcagtctctc atctggagat tacaacaagc 1658281 actggtgaag gagctgggac gaagctcgtc ctccaaggag gaaacatcat ttccgaatcg 1658341 cgttcctcaa gcaggaaggg aactgaaatt gtcgtttcca acctgttttt taacacaccg 1658401 gcccgtttga aatatatgaa aaccgttcat acagagcttg gaaacattac agatgtggtt 1658461 aaccgtattg ctctggcgca tccagaggta tcgatccgcc tgcgccatca tgggaaaaac 1658521 ctgcttcaaa cgaacggaaa cggagatgtg cgccatgtac tggcagcgat ttacggcacg 1658581 gctgtcgcca aaaaaatgct tccgctgcat gtgagctcct tggattttga agtaaaggga 1658641 tatatcgccc tcccagagat tacacgggcg tcgagaaact atatgtcgtc tgtggtcaat 1658701 ggccgttaca ttaaaaattt cccgctcgtc aaagcggttc atgaaggcta tcatacgctt 1658761 ctgccgatcg gacgccatcc gattactttt atagaaatta cgatggaccc gattttagtc 1658821 gatgtcaacg tgcatccatc gaagcttgag gtccggctca gcaaggaaac agagcttcat 1658881 gacttaatac gtgacggaat taaagatgtg tttaaacagc agcagctgat tcctagtgcc 1658941 caggtcccga aaaaatcagc acctgccatc aaaaatgagc agcagtttat aacctttgat 1659001 gaaaagcctc cggaaaaaaa agttccggaa aaatcgactg cgccatctta ttcaccgatg 1659061 aagctcagct cagtcgtaaa agagccggtt gatgcggagg aaaaattgcc ccctctccaa 1659121 tttgatgctc ctcctatcgt tgatcaggaa caaacccttg aggtgtccga tgtttcagca 1659181 gaacagcctg aaacatttga gcaggaatgc catgaggaac agccgcagcc agcgtctgat 1659241 cgggttccaa ttatgtaccc gattggccag atgcacggga cttatatatt ggcacaaaac 1659301 gaaaacggcc tatatattat cgaccagcac gccgcccaag aacgtattaa atatgagtac 1659361 ttccgtgaaa aggtggggga ggttgagcct gaggtgcagg agatgattgt accgctgacg 1659421 ttccactact ccacaaatga ggctttgatt attgaacagc acaaacaaga gctcgaaagc 1659481 gtcggtgtct ttttagagtc attcggctct aacagttaca tcgtccgctg ccacccagcc 1659541 tggtttccaa agggagaaga agcagagctt atagaagaaa tcattcagca ggtgctcgac 1659601 tccaaaaata tagatattaa aaaacttcgc gaggaagcgg cgattatgat gagctgcaaa 1659661 ggctccatca aagcaaatcg ccacctcaga aacgacgaaa tcaaagcgct tctggacgac 1659721 ctccgaagca catcagaccc atttacatgc ccgcacggcc gcccgatcat cattcaccac 1659781 tcgacatatg agatggaaaa gatgttcaaa cgcgtgatgt agcgggggtg gtaggcattg 1659841 atccattctc tgaatggatc aatgcttttt ttgtactcct tcgagtgtca gattataaga 1659901 aacggttgta aacgtgtgag cagtgttaac gcattatact tcatggttcc tccgtataac 1659961 aaaatttcca tttacaggca attgggatta atgtatattt tgggtgaggg ggtggaaaca 1660021 tatggcatgt ggtccgaaga tcattatctt tttggatgaa cttgatgatc caaatgtgag 1660081 aatcatttta gaatgcagaa tttaaattac aacattgtgt tttgctccct gttcgtgtga 1660141 acagggagat tttttcgttt atataactgg tgatgtccaa atatagggtg ttatgaattt 1660201 tccatatctg ccatcggctt taagctgctt ctctattagg ctggttatca aaagcaagtt 1660261 caatgatagc catgaaagct gatatcacaa caagcaagac atctggaata taaatagact 1660321 gcataaagta atctgcaaaa cagatcgtta taagattgct gataaaatac agtataaaag 1660381 caaaaagtgc agtctttttc aatgaaagtg attttgccaa aatgatagag ataatctttg 1660441 tgagtgggtc tatgattaaa cctacagcaa agcaggctaa aataaataaa gctaatgttt 1660501 gattggaagc gtatgtgatg ccaagtatgg agaataagcc tttcatcccg aagaaaaagc 1660561 cgccgaagat gactgcaagc gcgatggccg cgataaaagt aatagataca attccgatta 1660621 attttgatct caggttaaaa tctttagagt gctcgttctg ttctttttgg ttcatgtatg 1660681 acactccctt cacctgctta ctcatacaaa cagcaccctt gaatcagccc aaaatatcta 1660741 taagtctgtt ttctgacgaa aatagtatag catattttaa caaaaccaaa aaaggccctt 1660801 tccactgggg aagggccttt ttcatcatgt taactcctga gattcgccga agctttctct 1660861 ttttttggcc aaataaaata gctggctgta atgagaaagt caatgcctat aatgacagtc 1660921 cacagtttaa gaatgccgct caacgcctcg gttcgggaag agtcattgat aaaatagatc 1660981 atccctgcca atagtcccgc accaattaag taggccagca catgtcttag ccagcctttc 1661041 gcaccgtgct tggcatggtc cattccaaaa cgtttcagcg gttttgttcc tttttttgtc 1661101 acataatatt gaaacttttc atctgcccat tgaatcattt gtttcccata agcgatcgat 1661161 ataccgatgt aaacagctgc aatcccatgg gctgcggtcg ctgaggctcc gcggtaaagg 1661221 tccacaccag ttgccgctaa caagatcaaa tcgataactg gagttaaggc aaggaatagc 1661281 agtcctaatg tatgtcgttt gaatacgtag cgtacagcaa gccccaaaac aatgacaacc 1661341 caaaacgcaa tttcacagaa aacaatcatc catgcgatac cgttcaatcc attcccctct 1661401 tttcaataca gttgtattat ttaaataata tgttaccatc tttgtttttg taacacaact 1661461 gtattataaa aattgccccg cctttgaacg aaagctcaaa ggcgctacgc tgtattattt 1661521 tgatgaaagt ggctgtcagc tgtgctggat atcaattgta tatactgcac gatctgttac 1661581 gaccttcaat ccttcgtttt cttggtgaat atgaagctca cctaataaag gaatctcata 1661641 ggcattttgc ggaagcggta cgtttccgtc ctcagtgaat gttgttcctt cgccttctaa 1661701 aacaagctct tctttcgcaa cataatcatc aggatgattc gtactgcgta tagccacttt 1661761 ttgaaggtgg agaacaatct gatccaagtc tgatatctct tcatcatggg tcaattcacc 1661821 ttttctaata tcaagcgtct ggccgacttt tgattccagc cattgagaaa gctgtgtatt 1661881 cgtgtgtgcc atcaatattc ctccttttga tctacacgat actattccca attgctgcat 1661941 cttttacacg ggaaagagcc gccccactct ttatgtatga aacagttcgc tgttgagtgc 1662001 cttgatatag cgtacggcag aacgctggac cgattcgtcg gcattttctt tgacaacttt 1662061 agagaaagca ttgtaaagcc ggttgaattg aagcggtttt actttggctg ctatttcttc 1662121 aactttggag gcgggaaggg gaatgagatt tgggtagctg tacataaagc tgacccagtt 1662181 tcgatccgcc gcaaccgtaa tgatatctcc ggtcaataga cagcctttcc cttcattgcc 1662241 cttgctccaa tgcaaaacag caccgccttt aaaatgtccg cccagtcggt aaaggtccag 1662301 tcccggcttc atattgagcg tttcccctga ccagaagtga atgtgattgc ttggccttgt 1662361 cacccattct ttatcatcct catggatata gatcggcgcc tgaaacgctt cagcccactc 1662421 aacctgagta gagtaataat gtggatgaga caaggcgatg gcttgaatac cgcctaattc 1662481 gttgatttgg tcaattgtct tttggtcaag atatgtcatg caatcccaca gcacattgaa 1662541 gcccttatgc tgaataagat gggctgtttg tccaatcgca aactctggtt cagttttgat 1662601 gctgtaaaga tgctcttctt cctttttaag gatgttttga aggtttcctt tctcacgcat 1662661 gtcttcaagg gttgtccaag tttgtccatc gggatgaata tactgtcttt catcctcgca 1662721 aatcagacac gagttgggcg gatctacagt ctgtgcatgt tgcacaccgc atgtattgca 1662781 gatataatat ggcactttct tcacttcctt catctatttt ccattatttt accttatgat 1662841 tatgaatatt caaacgaaaa aaccggcagt tctgctgaga gagaattgcc ggcttttgat 1662901 gatgtttatt ggccgggaac ggaattttct gcgttgacag cgcccgctcc gtagatattc 1662961 ggatcttcat ctttccattt gtccgtgccg tttttcaaaa gctcttttac ttcatcaggg 1663021 gtaagatccg ggttttgctg aagaattaaa gctgcgattc ctgcgcaaat cggtgttgcc 1663081 atcgaggttc ctgacattgt aaagtactga gaccctacac ggcttgactt ttggagctta 1663141 tcaatataag aattcggaga gcgaagggaa ataatattaa cacccggcgc taaaatatcg 1663201 ggcttttctt tcccgtatac tgtcgggccg cggcttgaga aggaagcgac agtatcatca 1663261 tcgctgcttg cagtattgtt atcgtcaagc gcacctactg taatcacctt ttcgctcacg 1663321 cccgggcttg caatggtctg cgaatcaggg cctgagtttc cggcagcgac acagacgaca 1663381 atccctgcgc tccacgcttc ctcaaccgct ctgactaacg gatcttcctg ttcatgatca 1663441 tatctaaggg catcgccccc gagcgacatg ctcataatat caatcggttc atcggggttg 1663501 tcctcattgt attgaataca ccactcaaca ccctctataa tatctgctaa cgttcctgaa 1663561 ccctgcttgt ttaatacctt tacgccgatg agattggctt ccggtgcagg tccgcggtat 1663621 tgaccggaag aggatgcacc gctgcttgcg acatcacctg cacagtgtgt gccatgacca 1663681 ttatcatcgt acggctctgt tttttgattg accatgtccg cgaatccgat aattcttcct 1663741 tctagatcag gatgcgggta gattcctgta tcgacaacag cgacagtaac accttttcct 1663801 gtcagggttt gcccgtttct gacgacttcc ttcgcatggc ttgcttcggt tgccgtgtct 1663861 aaaagcgctt tgacttcgcg gtttaaatac actttacgga tattgctgca ttcagagaga 1663921 agggaatgta atgctgaagg agtaacctcg gcgctgcagc agttgatttt gttgaagcgg 1663981 ctttttagct tgctgcgttt ttctttttgc agcacctctc cagccatttg aaagccggtc 1664041 tcgtgacagc cttcctcaaa ttcgataatg actgacattt tttttctgtt ttgcaatttg 1664101 gtttcgaaaa atttatgcaa gaagcaagga gtccatttga agggcttgta aagttgcaat 1664161 acggtttccc gtaacggcca atctagcttg tgagcatttg ctctcaccat ttgtaccata 1664221 gagtacccaa acatgtattt tcctcctatt ataaggttct ctgtatactc tatgaacaga 1664281 tgataggttt ggtaagtttg tttgtcctct gtaagagaca gacaagagtt tgtttttctg 1664341 aatctttcgc attagatacg atagattcag aagctgagga aatcattggg gattgaaaaa 1664401 gaacgtttgt tcgtattata atgtgatcat atcaaactgg gaaggggaga gcaaccgtat 1664461 gaatttctac ttgcaccgat ctttggaaag ccaaatgcca atcagcatta tatatgaaga 1664521 aagacggaac gattagtaaa agaacgatta ttgtgagaca gaaaagcaaa acgaaaatca 1664581 aagcattttg tttttcgaaa caacagatca gaacattttt attggactct atcctctcct 1664641 gtgattttgt gagaacaaat aagcaaaatc tctattctgc aggccggtaa cagctgtccg 1664701 tctcagcaac cgggcagcct gttactaaaa ccctccttaa acctatatac atttatttgc 1664761 caagtgaggt tgttcctacc ttttttgtct ttcctctcaa ccttttttca ctcttatttg 1664821 aaatgaaccg ctaataaccg tgacaatcaa ttgatttttt gaaaccggga actttttcac 1664881 tgatgatatt gtgtatacaa tggtaagata aaacctattg gctaaacctc atataatgaa 1664941 ccgcgccatt cttatgaaag gagttaaaca tgagaagatt tttactaaat gtcatattag 1665001 tcttagccat tgtcttgttc ttgagatatg ttcattactc attggaacca gaaccatcaa 1665061 atcagccaga tacatattca aatttcagca gcttggcaga gaatgagagc ccagccgatt 1665121 acgatatttc atataatgag aaaaaaggaa gcaaagtctt aattatgtct ccgcatggcg 1665181 gaagaattga aggcggagta agtgagcttg tgcgttattt caataatgaa tactctacat 1665241 acctatttga agggttgaag tcccatgata accaaacact gcacattaca agcaccaact 1665301 ttgatgagcc attggcaaaa aagaaaatca aggagcatca atatgtggtg gcttttcacg 1665361 gatataaagg agagaacaag aatacccttg tagggggaac agaccgaaag cgggcgaaaa 1665421 tgattgtgag agcccttgag cggagagggt tttccgctga gttagcgtcg tctaaaagcg 1665481 gtcttgctgg attgaatgcc gaaaacatta ataaccaagg ggaaacgggg ctaagtatcc 1665541 agctggaaat cagccgtgag cagagagaag cattttttga tgatttttat tataaaaata 1665601 gaaaatacac aaagaacagt gaattttatg cttatgtcag tgcgatcaaa ggtgtcctgg 1665661 aaaaagagta ttcgtaacaa gcagatcaga agacaaaata agagaagatc agtagactga 1665721 aataggataa aaaaggaggc aaaacaatgg cagatcatca tttttattta aaagcgaact 1665781 ggccgggtaa ccgtaatgat gtcggtacga tcgaaagcgg aaacctgatc acatcgattt 1665841 ccattcctaa agaaatggat ggcccgggag aagggaccaa cccagatgaa atgcttctcg 1665901 gggcggcagc gacctgttac attattacac ttgcagcgat gatggagaga agcgggctgg 1665961 aaaaagaaga cttacagatg gagtcagaag gcattgtcaa cgttacaaaa ggagtcttta 1666021 catacaaaaa gatcattcac cgtccctctg tcgtgcttaa acatgatgct tcacaagacg 1666081 acgtcgcatt ggcgcacaaa ctttgtaaaa aagcggagtc gtcatgcatg atttcgcgtg 1666141 caattcaagg aaatgtcgag ctgcagcttg aagcctctgt gaaactgggt ggagaataaa 1666201 gaaaacagac ggtcactcac aggccgtctg ttttttatct tcagcgtggg ctttcgattg 1666261 atttagcacg accacgcctg caatgacaag cgtgagaccg aatacacctt ttaaactgat 1666321 ggtttcgcca aaaagcaaaa acccgacaat tgctgtaagc gcggtaccaa cgcccgacca 1666381 tgttgcatac gcgcttgata agtcaattgt ttttaaagaa aagcttagaa acgtaaaagc 1666441 agaaagaaat ccgactatga ctccggcaat gggccaggct tgtgtaaatc cttctgaaag 1666501 cttcaacatc gtgctcccaa acacttcaga tacaatggcg agagccaaat aaagcaatcc 1666561 tctcatcttc atcactcctt tacggccaat taagtaacac gacccctgat agtaataaaa 1666621 gaatcccgat aagccctttg gcattcagat cttccttgaa ccattttact ccgatcactg 1666681 tcgtcagcac cgtgcctgcc ccgctccaag tcgcatagga gaggctcagg ggaatatggt 1666741 ttaaagtcag ggacagcata taaaaggcga gggaatagcc aataacgacc aaagcacttg 1666801 gcttccactt tttgaagcca tcagatactt tcagcatggc tgctcctatc gattccgaac 1666861 atatggcaat cgtgaggaat atatatccta tcaacatcat gaattctcct cactatattt 1666921 ttagattaga aaaaaaactt cagctagaaa aatattagtg tatgcctatg tatgagtcaa 1666981 gagattcatt ttcacacact taaaaagacc cctttttaag gggtcttttg cgtttaataa 1667041 taaaaaggga acggggcata cggataatag gggtatccgc catacaaata aggattaaat 1667101 aaagcgcttc ctataagccc gcctgcaagg ccgccgataa acggtcctcc aaaaaatccg 1667161 aatggccggc caaacccata accaaatccg ggtcttccaa acccgtaacc gaacccgaac 1667221 ggtcttccaa acccaaatgg tctcccgaat ccgaacggcc ttccaaatat tcttgtatct 1667281 tcagggctga aatgctctaa ctcgttcatg ttttctttcc tcctgtaata aagtgtagat 1667341 gatgcagtgt attcaccctg cccggatttg attgggcgaa tcgaggaaaa ggaggatgtg 1667401 aacacattgg gcctgtatca gtctgactgg tcaaaagcac cgccccacgc acatgcttat 1667461 catgtcaaaa caacgagaga acagggccat tatcatctca tcgaagggtt tactcagccg 1667521 gcaaacggat caaataccga tcagcataca cattactata cagggatcac ttcatttgaa 1667581 aacggccatt ttcatcggta ttacggaatc tcaggaccgg cgattccctt agcagatggc 1667641 acacattatc atgaaatcga agaaacgacg tatctggcct ataacgagcc gattgagatc 1667701 cagtacggag gggttgtgta cgatcccgga gatgacagaa gaaaaacgca tcgtcatacc 1667761 ctgaaaggaa agacaaggga aattgtcggc aatgagccgc tcggctggta gaaggatgtt 1667821 taccgatgca aaaaaagggc aaaatggata ggtggttgtc catgttgaat gctataatgg 1667881 ggggagattt ataaaagaga gtgatacata ttgaataata cgaagcagcc cgttgtcatt 1667941 ttagtcggac cgacggcagt ggggaaaacc aatttaagta ttcagctagc caaatcctta 1668001 aacgcggaaa ttatcagcgg agattcgatg cagatttata aagggatgga tattggaaca 1668061 gctaaaatta ccgaacagga gatggaggga gtgccccatc atctgattga cattttagat 1668121 ccccaagact ctttctctac tgccgattat caaagcttag taagaaataa aatcagcgag 1668181 attgcaaata gaggaaagct tccgatgatt gtcggcggta cagggcttta tatacaatct 1668241 gtgctttacg attatacatt tacggaagag gcaaatgatc ccgtgtttcg agagagcatg 1668301 caaatggctg ctgagcggga aggcgctgac tttcttcatg ccaaacttgc tgcagcagat 1668361 cccgaggcag cagctgcgat tcatccgaat aatacaagaa gagtcattcg cgcactggaa 1668421 attttacata cgtccggaaa aacgatgtcc cagcatttga aggaacaaaa acgagaactt 1668481 ctgtacaatg cagtgttaat tggcctgaca atggatagag acacgcttta cgaaagaatt 1668541 aatcagcggg tcgatttgat gatgcagtca ggccttcttc cggaagtgaa acgcttatac 1668601 gacaagaacg tgagagactg tcaatcaata caggcgatag gctataaaga gctgtatgca 1668661 tattttgacg gttttgtgac actttccgat gctgtcgaac agctaaagca gaactcgagg 1668721 cggtatgcga aacgccagct gacgtggttt cgcaacaaaa tgcaggtcac atggttcgat 1668781 atgacaccgc ctgttgatat ggagctgaaa aaaaaggaaa ttttcacaca tatagcagga 1668841 aaactcgaac tttaatcgaa actgtatgat atagagaatc aaggaggacg aaacatgaaa 1668901 ccgattaata ttcaggatca gtttttgaat caaatccgga aagaaaatac gtatgtcact 1668961 gtttttttgc tgaacggctt tcagttgcgg ggccaggtga aaggctttga taactttacc 1669021 gtattgttgg aatcggaagg taagcagcag cttatatata aacatgcgat ctcaacgttt 1669081 gcgccgcaaa aaaacgtcca gcttgaactc gaatagatca aaaaatgcca tgtcaagaca 1669141 tgaggaaagg ctgtcggggg ttcccggcgg ccatttttaa catgaatcca cttttgctcc 1669201 aagctttttg tgtaagctga ccatgccaag gcacggtctt tttttatgag aacaacatac 1669261 ggaagtaaaa atggtatatt atgtataaaa tgaatttggg agtgatcgat cttgtttgaa 1669321 agtgaagcag aactgagacg aatcaggatt gcacttgtat ggatagctgt ctttttactg 1669381 ttcggggcgt gcgggaatca agataccatt attgaaacag acaacggcaa ttcagactat 1669441 gaaacgcctc agcccacctc gtttccactt gaacataacc attttggcgt tatggaggac 1669501 ggctatatca aaatttatga gtataatgag tcccgcaatg aggtaaagct gaagaaagaa 1669561 tacgcggatg atgagcttga ataaaattca caagcattcg aatttacaaa gcggatgcca 1669621 gccgctaaac taaatacaga cacagatcaa acagagggtg aaaacatgaa gcataaagtg 1669681 atcgtgaatc attgggaaga aatttgcgaa gatgattctt gctatgaata cggaacaagt 1669741 atcattgtga acggaaaaga attaatcaga gaagcgtcaa ttatcactgc tttgaaggcg 1669801 gttttagaag agatcggcgc ggatgttgaa atagaagaaa cagtagagag cgaaaaatgc 1669861 tgtgatagct taagaaaaaa aaatctagac tactaagcag ttttttttca tgttatgata 1669921 tacatcggct aaaaacgaca ccccgagtag gacgagagat gattctcgtt ctgctctctt 1669981 ttttgggccc taatgagtct gcccgtttgc ctgatttgat caaaatatga atttttcata 1670041 aaaacgaatc tatatattgt gtttttgcta gagggtagta tactatatat agtgttagtg 1670101 atgagagatt catatttttt gataggtcgt gataaaacgt ggtacaaatc atatttgatt 1670161 cgaaaacagg gaatgttcag cggtttgtga ataaaacagg ctttcagcag atacgcaagg 1670221 tggacgaaat ggaccacgtg gacactccgt ttgttttggt cacctacacg acaaacttcg 1670281 gccaggtacc ggcatcaaca caatcatttc tcgaaaaata cgcccatctc ttattgggag 1670341 tcgctgcgag cggcaacaaa gtatggggcg ataactttgc aaaaagcgcc gataccattt 1670401 caagacaata tcaggtgccg atcttgcaca aatttgaact cagcggcaca tctaaagacg 1670461 ttgaattgtt tactcaggag gtagaaagag ttgtcacaaa atcaagtgcc aaaatggatc 1670521 cagttaaata acgaaatcat gatccaaaaa gatgggaaat tccagtttga taaggataaa 1670581 gaagctgtac atagctattt tgtagattat atcaatcaaa acacagtctt ctttcacaat 1670641 ttaaaagaga agctggatta tttggttgaa aaccaatact acgaagagga attcttaagc 1670701 ctttattctt ttgaagacat taaagaagtg tttaagacag cttacgctaa gaagtttcgt 1670761 tttccttcct tcatgagtgc gtttaaattc tataatgact atgctttgaa aacgaatgac 1670821 aagaaaaaaa tcctcgagcg ttatgaggac cggatctcaa ttgttgcgct gttcttcgct 1670881 aacggcgaca ctgagaaagc aaaagaatat gtaaacctga tgatcaatca agaatatcag 1670941 ccgagcacac cgacattttt gaatgccggc agaaaacgcc gcggtgaact tgtgagctgc 1671001 ttcttgctcg aagttaatga ttctttaaat gacatttcaa gagcaatcga tatctccatg 1671061 cagctttcta agcttggtgg cggggtttct cttaacctgt ccaagcttcg cgcgaaaggt 1671121 gaagccatta aagatgttga gaatgcgaca aaaggcgttg taggcgtcat gaagcttctt 1671181 gataacgcgt tccgttacgc tgaccaaatg ggacaaagac aaggctccgg cgcggcgtat 1671241 ttaaacattt tccaccgcga tatcaatgat tttcttgata cgaaaaagat ttctgcggat 1671301 gaagatgtgc gtgtcaaaac gctttcgatc ggtgttgtca ttccggataa gttcgttgag 1671361 cttgcacgcg aggacaaagc ggcttatgta ttctacccgc acacgattta taaagagtac 1671421 ggccagcaca tggatgagat ggacatgaac gaaatgtacg acaagtttgt cgacaaccct 1671481 cgggtgaaaa aggaaaaaat caacccgcgg aaactgcttg aaaaattggc gatgcttcgt 1671541 tctgaatcag gctatccata catcatgttc caagataacg tcaataaagt gcatgcgaat 1671601 aaccatattt ccaaggtcaa attttctaac ctttgctctg aagtgctgca ggcatctcaa 1671661 gtttcttcat acacagacta tgatgaagaa gatgaaatcg gtctggatat ttcctgcaac 1671721 ctgggttcgc ttaacattct caatgtcatg gagcataaat caatcgaaaa gacagtcaag 1671781 cttgcgacag actctttaac acacgtgtct gaaacaacag acatccgtaa tgcgcctgct 1671841 gtaagacggg caaacaaagc gatgaaatca atcggcctcg gtgctatgaa ccttcacggc 1671901 taccttgcgc aaaacggcat tgcgtatgaa agtccggaag cgcgtgactt tgcaaacacg 1671961 ttctttatga tggtgaattt ctactccatc cagcgttctg cggaaatcgc aaaagagaag 1672021 ggcgaaacgt ttgatcaata tgaaggatca acctatgcga caggtgaata cttcgacaaa 1672081 tacgtttcaa ctgatttctc accgaaatac gaaaaaatcg ctaatctgtt tgaaggtatg 1672141 catatcccga cgacagagga ctggaaaaag ctaaaagcat ttgtcgctga acacggtatg 1672201 tatcacagct acagattatg cattgcgccg acaggctcta tctcatacgt tcaatcaagc 1672261 acggcgtctg ttatgccgat tatggaacgg attgaagaac gaacatacgg caactcaaaa 1672321 acgtactacc caatgcctgg gcttgcatct aataactggt tcttctataa agaagcctac 1672381 gatatggaca tgttcaaggt tgtggatatg atcgccacta tccagcagca cattgatcag 1672441 ggaatcagct ttacattgtt cttaaaagac acaatgacga cccgagattt aaaccgaatc 1672501 gatctgtatg cacatcatag aggaattaaa accatttact atgcaagaac gaaagatact 1672561 gggcaagaca gctgcctttc ttgtgttgtt tgattaaagg agagtttata gtgacaaaaa 1672621 tttatgacgc agcaaactgg tcaaagcatg aagacgattt tacccaaatg ttctataacc 1672681 aaaacgtgaa acagttctgg cttccggaag agattgcttt aaacggcgat ctcctcacat 1672741 ggaagtacct cggaaaaaat gagcaggaca cttatatgaa ggtactggcc ggacttacgc 1672801 ttcttgacac agagcagggg aatacgggga tgccgatcgt ggctgaacac gtagatggcc 1672861 accagcggaa agcggtgctg aactttatgg cgatgatgga gaacgctgtc catgcgaagt 1672921 cgtactctaa tattttcatg acccttgcac cgactgaaac gatcaatgaa gtatttgaat 1672981 gggttaaaca aaataaatat ttgcagaaaa aagcgcaaat gattgtcggg ctttacaaag 1673041 ccattcaaaa agatgatgaa atttcactgt tcaaagccat ggttgcttcc gtctatctgg 1673101 aaagcttcct tttctacagc ggtttctatt atccgttata tttctacgga caaggaaaac 1673161 tgatgcaaag cggtgagatc attaacctga tccttcgtga cgaagcgatt cacggcgtgt 1673221 atgtcggtct ccttgctcag gaaatttata ataaacagac agaagagaaa aaagcagagc 1673281 ttcgtgaatt tgcgatcgac ctcctgaatc agttatatga aaatgagctt gagtatacag 1673341 aggacttgta cgatcaagtc gggctctcac atgatgtaaa gaaattcatc cgctataatg 1673401 cgaataaagc gctgatgaac cttggatttg atccatactt cgaagaggaa gacattaatc 1673461 cgatcgtttt aaacggatta aacacaaaaa caaaatcgca tgacttcttc tctatgaagg 1673521 ggaatggcta taaaaaagcg acagttgagc cgctcaaaga tgatgacttt tattttgaag 1673581 atgaaaaaga gcagatataa tatctgctct tttcggcttg aaggttcaaa tgaggaggac 1673641 gcagtaccca tgggaaaaat ggacgaaatg attttagttg ccccgcgcga tgatgtgttt 1673701 aaaaaagaaa gcttaacctt ccagggcgtg tacagtgaag atagcagagt agcagaaatc 1673761 atggctcaga ttgaagcggc ctatcgtgaa atgagaagag gggacgcaga agaagatccg 1673821 cgtttcaagc agccgatacc ttatgtcgtc attaagcgtg aagatgaagt ttttctttac 1673881 gagcggctgg ctggcggcgg tgaatcacgt ctgcacaaca agctttctct cggttttggc 1673941 ggccatatga acgccatcga aggggcagct tcatttgctg aagtcttaaa gctgaacaca 1674001 gaccgtgagc ttgaggaaga actgcaaata aatgaagaag ataaacaggc gattgtcaca 1674061 ctgggattga tcaatgatga tgaaaacagt gttggcaaag tgcatatcgg tattctttct 1674121 gcgcttcaat taaagcctgg cgcacaagtg gaagtgaagg agaaagaaca aattgcgggt 1674181 aaatggatga aagtttctga attaaaacag gatgatatct acaaccgtct ggaaacatgg 1674241 tcacagtttg ttgttgatat tcttgaataa aaaaacccgg tttctcgcga tgaggagccg 1674301 ggttttttta tgagacgctc gtccccgtct cggctatgat tctaggatca caatagcgtc 1674361 aaagccggca tttttcgctc tggcagcgag ggtgtctgca ttgtctttgg atgaaaatgc 1674421 gccaatctgc actttgtata atccgtcctt taaaaggaca atcgagtcaa aacctttggc 1674481 ttcggcatta cttgcgagcg agtcggcatt cgctttgact ttaaatgcgc cgatttgaac 1674541 cttatataac cctgagctgg aagtcttttt aaggttaaag gcttgctcca gcccgtttgc 1674601 atgtcctctc gctaagcttt gaataaaact gctcgttttc agcttatttg catcggaaac 1674661 ggtatcaatg aagccgttct cggtcaagag ggcaggcatt gccgactccc ttaggacgtg 1674721 gaagttcgct gtttttttgc cgcgatcggc aaagtcgaca gcttgtatca cttcagagtg 1674781 aattgtcgat tgataagtcg tcgtcggggc tcctacatct ggataaatat agctttcaaa 1674841 acctgtgcct cccccggaat taacgtgaat ggacaaaaag aaatctgctc cccagttatt 1674901 tgcggcattt gtccggtcgt ttaagctgac atattggtcg cttgtccggc tcagcagcag 1674961 agaaacgcct tcatattcat tagttaatat cgtacgtaag gctaaagcga tttgcagggt 1675021 taacgttttc tcctgaaggc cattacctgt tgcgcctgga tcagacccgc catggccagg 1675081 atcaataaaa attttaacca tttttcatca cctcattaca ggatatgaaa aaacacggct 1675141 tctgcttgta cgattatcat tcaactgaaa aatgaggaaa taaccctttc acatccagaa 1675201 attatttctc gggaaagcgc acaattcaac atgaagcgac aacagatacg gtccgacatg 1675261 aaatctgtgc atacgccata tgtttgtatg tactatgggt tcggttaacc tgcactgatt 1675321 cctgctggtt ttaagctttg cgttcatatt aaatcaagca tttaaaacgt aaattgatga 1675381 ggaaagctcc tttcattaaa gacaccgctt tataaatcga aaaaaagaaa aacacttcag 1675441 gtatcttagg gcgggtaata cgtttcgtac aaaaatcagc ccgttgtatg aaaaagaaat 1675501 aatgagaaag aagctcacta taatactctg acaaaatgat taaaaacaaa atctcatggt 1675561 ttgtccaccc catgtccgtg aatacaataa gaaataaagt atttctcggg aaagcgcagg 1675621 attccttatt gttcccgaaa aaagcaattg tttcgacaca tgataggcgt ttgtcacaat 1675681 cggcatccgc ttgaatatca tatagagaga acagagaggt gaagatgttg gagcgcgctg 1675741 tgacttataa aaacaacgga cagatcaaca ttattctgaa cgggcaaaag caggtgctga 1675801 cgaatgctga ggcagaggcg gaatatcagg ctgcattgca aaaaaacgaa gcaaagcacg 1675861 gcattttgaa ggaaatcgaa aaagagatga gcgcattagt tgggatggag gaaatgaaac 1675921 gcaacatcaa ggaaatatac gcctggattt ttgtgaacca aaaacgcgcg gagcaaggct 1675981 tgaaggttgg aaagcaagcg ctgcacatga tgtttaaagg aaatccggga acgggaaaaa 1676041 cgacggttgc acggctcatc ggcaagctgt tctttgaaat gaatgtcctg tcaaaaggcc 1676101 acttaataga agcggagcgg gctgacctgg tcggggagta tatcggacac accgcccaaa 1676161 agacgagaga tttaatcaaa aagtcattag gtggcatttt gtttatagac gaagcctact 1676221 cgctggcaag aggcggcgaa aaggactttg ggaaagaagc gatcgacaca cttgtaaagc 1676281 atatggaaga caaacagcat gagtttattt tgatactcgc cggatattca cgggaaatgg 1676341 atcattttct ctcgttaaat cccggactcc aatcaagatt tcccatctcc attgattttc 1676401 cggattactc tgtgacccag ctcatggaga ttgcgaaacg aatgatcgat gaaagggaat 1676461 accagctcag tcaagaagcg gaatggaaat tgaaagatta cttaatgaca gtgaaaagca 1676521 cgacaagtcc cattaaattc agcaatggac gttttgtcag aaatgtgatc gaaaaatcga 1676581 tcagagcaca agccatgagg cttttaatgg gagaccaata cttaaaaagc gacttgatga 1676641 ccatcaaaag ccaagatctt tccattaaag aagaagcatc tggatctgca tagacctctc 1676701 agtttttgag aggtctgttt tttgctcgta tttccgcttt tcaaagcaat cgatttgtgg 1676761 tatacacatg cagggtttgg tatgataata ctactgccca atatgcaaaa gaaaggaaca 1676821 tccatttgaa cgaacaagaa acgattcagg agaaagccat tttagtcgga tgtcagctgc 1676881 cgcatatcac ggatgagcat tttgaaaatt ctatggaaga gctagcatct ctgacgaaaa 1676941 cagcagacgg aaaagtactg accagcgtca cacaaaaacg gaacagggct gacgccgcta 1677001 catatatagg aaaagggaag gtagaagagc tgaaggcact cgtggaagag cttgaagctg 1677061 atctcctcat ctttaatgat gaactgtcgc caagtcagct gaagtcattg gcaacagcaa 1677121 ttgaagtgaa gatgattgac cgcacgcaat tgatattaga tatttttgca aagcgggcga 1677181 gaacgagaga aggcaaactt caaattgagc tggctcagct gcaatatgca ctgccgcgtc 1677241 tgacgggaca agggatcaac ctttcccggc aaggcggagg aattggggca agaggtcccg 1677301 gggaaacgaa actggaaacc gaccgccgcc atatcagaaa tcgcattcat gaaatcaaca 1677361 cacagctttc cactgtcatt cgccatagaa gccgataccg tgaaagaaga aagaaaaacg 1677421 gtgtgcttca aattgcgctt gtcggctata caaacgcagg gaaatcaaca tggttcaacc 1677481 gcctgacgag tgctgacagc tatgaagaag acctcctgtt tgccacgctg gacccgatga 1677541 ccagaaaaat ggtcctgcca agcggctaca gtgttcttct ttcagataca gtaggattta 1677601 ttcaggatct tccgacgaca ttgattgctg cattccgctc aacgcttgag gaagtaaaag 1677661 aagcggattt aattctgcat ttaattgatt cttcaaatga ggattatgcg ggacatgaaa 1677721 aaacagtgct tcggctgctt gaggagcttg aagcagatga tatcccgatg ctgacggctt 1677781 acaataaacg tgatcaaaaa ctgcctgatt ttataccgac cgccggaagg gatcacatta 1677841 tggtcagtgc gaaatttgag gacgacgctg cagcctttaa agaagcgatt cagcgctatt 1677901 tgcgccaaga actgttaacg tcttttgaag cacatgtgcc ggcaagtgaa gggaagctcc 1677961 tttccagaat caaatcggaa acgatggtag accgcttcta ttttaatgaa gaaaatgaac 1678021 agtatgacat atccggctat gtccaagaag agcaaagtat catcggtgaa ttaaagaagt 1678081 atatgtagga aggaaatata aagacatgtt tgacacatta acacacggag aattattgaa 1678141 gaaaacggca atggaagtgg aagcggacat tgccggcatt cataaacaaa tagaagaaat 1678201 cagcgagcga aatgagtgga gagtgcttca aagctataga aaacacaaag taagcgacac 1678261 tcatttcacg ccgtctactg gatacggcta tgatgatatc ggaagagaca cgcttgaaag 1678321 catatatgcg gatgtgtttg gcggagaagc ggggcttgta aggccgcaaa tcatttcagg 1678381 cacacatgcc atctcaattg ctttgttcgg tgtcctcaga ccgggggacg agctccttta 1678441 tatcacgggc aagccgtatg atacgctaga ggaaattgtg ggcgtcaggg gtggagaaaa 1678501 cgctggttcg ttaaaggatt ttcaaatcgg ctataatgcg gttgatctga cgaaagacgg 1678561 aaagatagac tatgatgcag tcgccgctgc gatcaatccg aagacaaaag taatcggcat 1678621 tcagcgctca aaaggatatg cgaatcgccc ttctttctta attagtgaaa taaaagaaat 1678681 gatccgtttt gtaaaagaaa tcaatgaaaa tctgatcgtc tttgtggaca actgttacgg 1678741 agaatttgtg gaagagcttg agccttgcca tgtcggagcc gacctgatgg cgggatctct 1678801 cattaaaaat cccggcggcg gccttgcgaa aacaggcggc tacctcgtcg gaaaagcgaa 1678861 atggattgaa gcttgctcat accgtatgac gtcacccggc atcggcagag aagcgggggc 1678921 atctctttac tcgctccaag aaatgtacca aggcttcttt ttggcgcctc acgttgtgtc 1678981 tcaaagttta aagggagcgg tgtttacagc gagattcctt gaaaaactcg gcttcacttc 1679041 aaacccgaaa tgggatgcga aaagaacgga tttaatacaa tccgttgagt tttctgacag 1679101 agaaaagatg attgcttttt gccaggctat tcaatttgca tcgccaatca atgctcatgt 1679161 gacgccttat ccagcctaca tgcctggata cgaggatgat gtcattatgg cagcagggac 1679221 gtttattcaa ggagcaagca tcgaattatc agctgatggc cctatccgcc cgccgtatgt 1679281 agcgtatgtt cagggaggat taacctattc gcatgtgaag aatgccatat gcagtgcagt 1679341 ggattcattg atgcaaaagc aattaattta aattttttaa aaatttctct ggatttgatg 1679401 ttaagaatcc ttacatcgta ttgacacata atataacatc acctataatg aaactaagtt 1679461 aagaaaagga ggaaattgag atgagtgata atattcgccg ctcaatgcct ttatttccaa 1679521 taggaattgt catgcagtta actgagttat cagcaagaca aattcgatat tatgaggaaa 1679581 atggactgat atttccagcc agaagtgaag gaaatagacg attattttca tttcatgatg 1679641 tagataaact gttagaaatc aagcacctga tagaacaagg tgtaaacatg gcaggaatta 1679701 aacagattct ggcgaaagcc gaagccgagc cagaacaaaa acaaaacgag aagacgaaaa 1679761 aaccaatgaa acatgatctg tccgatgacg aactgagaca gctcctgaaa aacgagctca 1679821 tgcaagccgg ccgttttcaa agagggaata cattccgtca aggcgacatg tcccgcttct 1679881 ttcattaatc cgttagcaac tgttttgcta tatacattta ccttttaaga ggaggaattt 1679941 taccaaatgg caaagtacac tagagaagat atcgaaaaat tagtaaaaga agaaaacgtg 1680001 aagtatatcc gccttcaatt tactgacatt cttggaacaa tcaagaatgt tgagattcct 1680061 gtaagccagc ttggaaaagc gcttgataat aaagtcatgt ttgacggttc ttctattgag 1680121 ggattcgttc gtatcgaaga gtcagacatg tacctgtatc cagatctaaa tacatttgtt 1680181 atcttcccat ggacagctga aaaaggtaaa gtagcacgtt tcatctgtga tatttacaat 1680241 ccggatggca caccttttga aggtgacccg cgaaacaact taaaacggat tctgaaagaa 1680301 atggaagacc tcggcttcag tgattttaac cttgggcctg agcctgaatt cttcttattc 1680361 aaattggacg aaaaaggcga gccgacgctt gaactaaacg acaaaggcgg atatttcgac 1680421 ttagctccaa ctgatttagg agaaaactgc cgccgcgata tcgtacttga gcttgaagag 1680481 atgggctttg aaatcgaagc gtctcaccac gaagtagcac ctggtcagca cgaaatcgac 1680541 tttaaatatg ctggagcagt ccgctcttgt gatgacatcc aaacatttaa actagttgtc 1680601 aaaacaattg cccgtaaaca cggcctgcat gcgacattta tgccaaaacc attgttcggt 1680661 gtaaacggtt caggtatgca ctgcaatcta tcactcttca aaaatggtgt taacgcattc 1680721 tttgacgaaa acgcagatct tcagttaagt gaaacagcga agcacttcat tgcaggtatc 1680781 gtgaagcacg caacaagctt tacagcagta acaaacccga cagtaaactc ttacaaacgt 1680841 cttgttcctg gctatgaagc accttgttat gtagcatgga gcgcgcaaaa cagaagcccg 1680901 cttatccgta tcccggcttc tcgcggcatc agcacacgtg ttgaagtacg cagtgtagac 1680961 ccagctgcaa acccatacct tgcacttagc gtattgcttg ctgcaggatt agacggaatc 1681021 aaaaacaaac tggaagcgcc ggctccaatc gaccgcaaca tctatgtgat gagcaaagaa 1681081 gagcgcatgg aaaacggaat cgttgacctt ccagcaacac ttgcggaagc actagaagaa 1681141 ttcaaatcaa acgaagtcat ggtcaaagcg ctgggcgagc acctattcga acacttcatc 1681201 gaagcaaaag aaatcgaatg ggatatgttc cgcacgcaag tacatccttg ggaacgcgaa 1681261 cagtatatgt ctcagtatta atatctcaat cccttggcac taaaagtgtc aggggatttt 1681321 ttatgttaat aggtaataaa ttatggagcg gcatagtgtt taacacagcc attaatcctc 1681381 agacagtcaa atagccattt ctactccggt tgaaagcttc tctatttttg cttcttattt 1681441 atctttcctg tattgatata tgtatgtagg gttggactta taacataaac tattctggcc 1681501 attccgttct ttcaattcat gaccgggctt gccatcagca taaatctagg ctaacagtct 1681561 ccatacatcc tgtgatcacc tttatcaaac tcttaaatgc aacttaccac taaccaattc 1681621 tttatttcgc atagatcatc tttgtcatgt gtttacacaa gaatctgttt tggactgaga 1681681 cactgaatat aacaaaacag tcaaaaatca atatttaatt cattctgttt aaactttctg 1681741 aaaaagatgt tgaaaaagtc gaaaggattt tataatatta agtcaagtta gtttgtttga 1681801 tcaacaaact aatgaaatga actttcatta tccacaagat aagatcttac taatatggat 1681861 ggaaggggga taagagggtc gatttaatgg agctaaacaa tataagaaac gaaagaatga 1681921 ggcttttatc cttttccagg tatataaggt atgacgaaaa aagatgaatt ttttgcttgc 1681981 tgatcaccat atttttttgc actgttttga aagcgctttt ataaaagttt actgaccgta 1682041 aattcgagaa attgttatac cgtttcacac tgttccatat taaaggatcg aaaaggggag 1682101 aaatcatgct cagtgaaaat gtaaagaaga ttagcatggt tgaaaaagtt ggatatgcgt 1682161 ctggagattt tgcttgtaat ttaatttatg caacagtgtc tacgtatctt ttgttcttct 1682221 atacagatgt ttttggttta tcggcagcag cagccggtac tatgttttta gtggttagaa 1682281 taatcgacgc tctcgctgat ccttttatcg gaacaatagt tgacagaacg aacagcagat 1682341 ttggacgctt tagaccgtat cttttattcg gagcttttcc atttgtcata ctggcaatac 1682401 tctgttttac aacaccagac ttttcggata tggggaaatt aatatatgcc tatataacct 1682461 atgttggctt gtcgcttaca tacacaacga taaacgttcc atatggcgcg ttaacttctg 1682521 caatgactag aaataatcaa gaagttgtta gtataacttc tgttcgcatg ttatttgcga 1682581 atcttggggg acttgtcgtt gcattttttg ttcccttact ggctgcttat ttaagcgata 1682641 cttccggcaa cgagtctctt ggctggcaac taaccatggg tattttggga atgataggcg 1682701 ggtgcctttt aatcttttgt tttaaaagca caaaagagcg ggtcactctt caaaaatccg 1682761 aagagaaaat taaatttacg gatatatttg agcagtttcg tgttaatcgt ccacttgttg 1682821 tattaagtat tttctttatt attatttttg gagtgaattc catcagtaat tcggttggca 1682881 tttactacgt aacgtataac ttagaaagag aggatttggt gaagtggtac ggtttgatag 1682941 gaagtttacc cgctttggtc attttaccgt ttattccaag gcttcatcaa tttttgggga 1683001 aaaagaaatt actaaactat gcattattac tgaatattat aggcctctta gctttactgt 1683061 ttgttccgcc aagtaatgtt tacctcatac ttgtctgtcg attaatcgct gctgctggaa 1683121 gtctcactgc cgggggatat atgtgggcgc ttattcctga aacaattgaa tatggagagt 1683181 acaggactgg gaaaagaatg ggtgggctca tttacgctat aatcggattt ttctttaagt 1683241 ttggtatggc cttaggagga gttgttccgg gtctggttct tgataagttt ggatatgtag 1683301 caaatcaggc acaaaccccg gcggccttaa tggggatttt aattacaaca accattattc 1683361 ccgtgttctt gcttgttcta gctttaattg atattaattt ctataactta gatgagaaaa 1683421 aatataaaaa catggttcga gaattagaga atagagacaa agtttatttg gatcatattg 1683481 atgatttcaa ggcttaaaaa agaaaataaa ctgaggagga gtcccaaatg aagattacca 1683541 atcccgtact taaaggattc aatcccgatc caagtatttg tagagcagga gaggattatt 1683601 atatcgctgt atctacattt gagtggtttc cgggagtcca gatacaccac tcaaaagatt 1683661 tagtaaattg gcacttagtt gcacatccat tacagagagt ttcacaatta gacatgaaag 1683721 gaaacccaaa ttcaggtgga gtttgggcac catgtttaag ctatagtgat gggaagtttt 1683781 ggctgatcta tacggatgtt aaggtagtag atggcgcatg gaaagattgt cacaattatt 1683841 tagttacttg tgaaacgatt aatggtgatt ggagtgagcc gattaaatta aatagctcgg 1683901 ggtttgatgc ttctttgttc catgatacgg atggaaaaaa gtatttatta aatatgttat 1683961 gggatcaccg tattgatcgg cactcatttg gaggaattgt tatacaggaa tattctgata 1684021 aagagcaaaa attaatcggt aaaccaaaag ttatatttga aggaactgat agaaaactga 1684081 cagaagctcc gcatctttat catatcggga actattatta tttattaact gcagaaggag 1684141 gaacacggta cgaacatgct gctacaattg ctcgttctgc aaatattgag gggccatatg 1684201 aagttcatcc cgataatcca attttaacgt catggcatga cccaggaaat ccattgcaaa 1684261 aatgtggtca tgcatccatt gttcaaacac atacagatga gtggtattta gctcatttaa 1684321 cgggacgtcc tattcatcct gacgatgatt caatttttca gcagagagga tactgtcctt 1684381 tgggcagaga aacagctatt caaaaacttt actggaaaga tgaatggccc tatgtagtag 1684441 gtggaaaaga aggaagcttg gaggtagatg caccttctat acccgaaaca atatttgaag 1684501 caacgtaccc ggaagttgat gaatttgagg attcaacatt aaatataaat tttcaaactt 1684561 taaggattcc attcacgaat gaattaggtt cattgactca agcgccaaat catttacgat 1684621 tattcggtca tgaatcattg acctcgacat ttactcaggc atttgtagcc agacgctggc 1684681 aaagtctcca ttttgaagcc gaaactgctg ttgagtttta tccggaaaat tttcaacaag 1684741 ccgctgggtt ggtgaattac tacaatacag agaactggac ggctcttcaa gtcacgcatg 1684801 atgaagaact tgggcgcatt cttgaattaa caatatgtga caacttttct ttttcacagc 1684861 cattaaataa taaaattgtt attcctcgtg aagtaaagta tgtatattta agagtaaata 1684921 ttgaaaagga caaatattat tatttctatt cttttaacaa agaagattgg cacaaaattg 1684981 acattgcact ggaatcgaaa aaattatcag atgattatat ccgtggggga ggattcttca 1685041 caggggcctt tgtagggatg caatgccaag ataccagtgg taatcatatt ccggccgact 1685101 ttagatattt tcgttataaa gaaaaataat ttgcacatga aaaaggagat ttctatttta 1685161 gaactccttt ttcatatgag aaggtgccat gtcactattg cttcagaaat actcctagaa 1685221 taaaaaaact catctttaaa gatgagctgt ccattccata aaaaattaca ttgtaatcat 1685281 gtccagaaaa tgatcaatca caatggagga cattcctaat gccggtgcat tctgtcctaa 1685341 ggaagatggc aataattcat agctattgcc taattgggaa taaacccttg atgatacttc 1685401 acttctcatt gaatttaaaa ccataggatg cgattcaatt atgctatttc ttaaaattac 1685461 ggcttgtggg ttgaaagtat ttagaatatt ggtaaggcct attcctaaat agaatccaaa 1685521 attttgtaat gcatttaagg ttccgatatc attcagatgg gcgaggttta tgatatcttg 1685581 ataggacagt tttttctctt tggtctgaag agattttaat aaagccttct ctgaagcata 1685641 caattcccag catcctcggt ttccgcaact gcatttagga ccattaaagt ctattgtcat 1685701 atgtcccatt tctccagaga agccgcttac tcctctatat aaatgattgt tgataataac 1685761 accgatccct attcctgtgc tgatacttac gtaaataatg ttatcgtgat tttttgcagc 1685821 tccaaatact ttttctccat atgcgccagc atttgcctca ttttcaataa aaacaggcac 1685881 attgtacttc tcttgtatcg aagattttaa gtcaatatct ctccagttgg agttcggagt 1685941 gaaaacaatt ttttgatctt tatcaatgag tccaggcacg caaataccta taccaataag 1686001 cccgtacgga gattggggca tttgcgtaat aaagtgatga atcatatcaa tcaaaatgtc 1686061 tttcgttatt tctggagaat tggattccaa atggcggtat tgatcaagaa cgattgttcc 1686121 ttcaaggtct gttaaaatgc cattaatata atccacacca acatctattc caacggagta 1686181 tcctgccttt ttattaaaaa caagcatgac aggtcttctt ccgccacttg attgtccttg 1686241 acctatttca aataccatac tttctttcat taacgtgttt acctgtgatg agacagttga 1686301 tttatttaat ccagtcattt cagataattt tgctcttgaa ataggtgaat ttttaaggat 1686361 ttcttttaat aataactttt gatttacttt tttgacaaag gtttgatcag cgatatccac 1686421 ttcatccact ccatttgttt aatctttaaa ttaagtatca acatagtaca tagcgaatct 1686481 tccctttatt atatctaatg tgttcataaa aaactaaaaa aaatattgaa aatactgacg 1686541 aggttatata agatgaaaat aagttagttt gtttaaacaa caaactaata ggtgatgtac 1686601 ttactatatg aaataaaatg catctgtatt tgaatgaatt tatttttaag ggggaaatca 1686661 catggctcaa tctcattcca gttcaatcaa ctattttgga agcgcaaaca aagtggttta 1686721 cgaagggaaa gattcgacta atcctttagc atttaaatat tataatcctc aagaagtaat 1686781 cggcggaaaa acgctgaaag agcatttgcg attttctatt gcctattggc atacatttac 1686841 tgctgatggt acagacgttt ttggagcagc tacgatgcaa agaccatggg atcactataa 1686901 aggcatggat ctagcgaaga tgagagtaga agcagcattt gagatgtttg aaaaactaga 1686961 tgcaccattc tttgcttttc atgaccggga tattgcacca gaaggcagta cgctaaaaga 1687021 gacaaaccaa aatttagata tgatcatggg catgattaaa gattacatga gaaatagcgg 1687081 cgttaagcta ttatggaata cagcaaacat gtttacgaat ccccgtttcg tccatggtgc 1687141 cgcgacttct tgcaatgcag atgtgtttgc gtatgctgca gcacaagtga aaaaagggtt 1687201 agaaacagca aaagagcttg gcgctgagaa ctatgtattt tggggcggcc gtgaaggata 1687261 tgaaacattg ttaaataccg atttaaaatt tgagcttgat aatttggcta gatttatgca 1687321 tatggcagtg gattatgcga aggaaatcgg gtacacaggg cagtttttga ttgagccaaa 1687381 accaaaagag ccgaccaccc atcaatacga tacagatgca gcaacaacca ttgccttttt 1687441 gaagcaatat ggcttagaca atcattttaa attaaatctt gaagccaatc atgccacatt 1687501 agccgggcat acattcgaac atgaattacg catggcaaga gtacatggtc tgcttggctc 1687561 tgttgacgca aaccagggtc atcctctttt aggctgggac acggatgaat ttccgacgga 1687621 tttatattct acgacattag caatgtacga aatcctgcaa aatggcggcc ttggaagcgg 1687681 cggattaaac tttgacgcga aggtcagaag atcttctttc gagcctgatg atctaatata 1687741 tgcccatatt gcagggatgg atgcatttgc aagaggattg aaagttgccc acaaattaat 1687801 cgaagatcgt gtgtttgaag atgtgattca acatcgttac cgcagcttta ctgaagggat 1687861 tggtcttgaa attatagaag gaagagctaa tttccacaca cttgagcaat atgcgctaaa 1687921 tcataaatca attaaaaacg aatctggaag acaggagaaa ttaaaagcga tattgaacca 1687981 atacatttta gaagtataac aggataagct ccagatcctg ctatcaatac caagtcactg 1688041 aattacccgt catgattcct ttcctattgc ttgttgttat gacgggtaac ttctataatt 1688101 aggatttatt tagagtgaat ggttttttaa aagggcaagg agtgaaaaaa tgaagtatgt 1688161 cattggaata gatcttggaa cgagtgctgt taaaaccatt ttagttaacc aaaacggcaa 1688221 ggtttgtgca gaaacgtcca aaaggtatcc gctcatccaa gagaaggcgg gatatagtga 1688281 gcaaaatcct gaagactggg ttcagcaaac aattgaagca ttggctgaat tggtttctat 1688341 atccaatgtt caagccaagg atattgacgg gataagctat tcgggacaaa tgcatggatt 1688401 agtactgctt gaccaagatc gtcaggtgtt acgtaatgca attctttgga atgataccag 1688461 aacaacgcct caatgtataa ggatgaccga gaaatttggc gatcatcttc ttgacatcac 1688521 aaaaaaccgt gttttagaag ggtttacatt acctaaaatg ttatgggtaa aggaacatga 1688581 acctgaactt tttaaaaaaa ctgctgtgtt tttgcttccg aaagactacg tgcgattccg 1688641 tatgaccggt gtcattcaca ccgaatactc cgatgcagca ggaactttac ttttacatat 1688701 tactcgcaag gagtggagca atgatatttg caatcaaatt ggtatttctg cagatatttg 1688761 tcctccgctt gttgaatctc atgattgtgt aggatcgctg cttccgcacg ttgccgcgaa 1688821 gaccgggcta ttagaaaaaa caaaagtgta cgctggggga gcagataatg cttgcggcgc 1688881 tattggagca ggtatccttt cttccggaaa aacattatgc agtattggga cgtcaggggt 1688941 catactttcc tacgaagaag aaaaagaaag agactttaaa gggaaagtcc acttttttaa 1689001 tcatggaaaa aaggattctt tttatacgat gggcgtcacg ctcgctgcag gatacagctt 1689061 ggactggttt aaaagaacgt ttgcaccaaa cgaatcgttt gagcaattat tgcagggggt 1689121 ggaagctatt ccgataggag ccaatggact gctatacact ccttatttgg ttggtgaaag 1689181 aacgccgcat gctgattctt ctattcgggg aagcttgatc ggaatggatg gagcccataa 1689241 tagaaagcat tttttgaggg caataatgga aggtatcaca ttctctttac atgaatcaat 1689301 tgagctattc cgcgaagcgg gaaaatcagt tcatactgtt gtttctattg gtgggggagc 1689361 taaaaatgat acgtggctgc aaatgcaagc tgatattttc aatacgaggg taattaagtt 1689421 agaaaatgaa caagggccag ctatgggggc tgcaatgctg gctgcctttg gaagcggttg 1689481 gtttgaatca cttgaagaat gtgcagagca gttcattcgt gaggctgctg cattttatcc 1689541 aaaggcgcaa aatgttcaaa aatataaaac actatttgat ttgtataaga acatttacac 1689601 tcacacaaag gatctcaata cagctttgaa gagctttcga aaaaactaat gatgttattg 1689661 tctggagatc aaccgaagaa caattaatga tcaatcatca tcaaaggcct ttgataacat 1689721 ggctgccttc ttttgaaaag atggtgagaa taaggtatcg caacctttaa acagtattgg 1689781 agtatccagc agacaaaacg aacgagtgga accgtatttt gtcagcgaac acttcaagaa 1689841 gtggggaagc ttaggaatgc caatgggtaa gatgtatgaa accgcgctaa cgacggtaga 1689901 gggatctctt gatttatgaa gaaataggaa ggatgttaac acacaaataa cccctcacat 1689961 tgacgtgaag gggtgttttt tattgttact atacagcgga aattttacag gctagttgca 1690021 tgattttagc ttgttaagca gaatggaact agactctcca tcatctcttt ctcattcttt 1690081 ggaaactgca ttctgctagg tttgctgctt tttttaacaa acagtgtttt tctatttcac 1690141 acagccatta aatcctctgt tcgtcacata accgctctta ctccaaattg acagtttatc 1690201 tgattttgct tcttgctcat ctagtctgaa ttggtctatg tattttgtgt taggctcata 1690261 tacatatgct actctggcca atccctcttt caataatgtc tcttgaacag atttgccgtc 1690321 aacataaacg tatgctaaca gtcttccata cttatctctg cgatcgcctt tatcaaattc 1690381 cagctgtagc ttaccgctgt tgaccaattc tttatttcgt ttcgacgcat cctcaccgta 1690441 tggttgaaca caagaatttg gtttcttcgt ctcaggtgta tcaacgagca agtagcgaac 1690501 tgtgtctttc tttccgttgt aaataacctt aatcgtatct ccatctattg ctctatctaa 1690561 tgtaacattg accaatttct tctgattttt tgaatgaggc gtgccagcct tttgttctgt 1690621 ctgattatat tcattagagt gagtatcttg agagacttgc tccgtcccat tagaatctga 1690681 atggtttttg gctgcgtgat ttgatccgca agctgccaaa gtaatactta aaacgattgc 1690741 gatcatactg atcaaaatct tcttcatatt gattccctct ttatcatttt ctcttttcgc 1690801 gattaaacat catcattata acgatatgga cattttttgt gaatggaaaa cttcaaggga 1690861 acttataaca ctccaaattg ccaatagtta acttcacaac gagatgatca aaacatcacc 1690921 atcacatagc ggaaataaat aatcctgaaa ataatattga ctgaaaatgc ttttagaatt 1690981 atgataatat gagaaatgac aataatgtga caaagacatt actacaacat aacaactaat 1691041 agcttaggtt tattctattg gttaaaaatg taaacggtta caaatccaga ggcgaaaatc 1691101 taagatagag atgactttag ttttgactca atatccacac tgaaagagct tattaagtat 1691161 tcttaaaggc aggggaaatg gatatgaatg aacatcgaaa tcgaaggttg aaattaataa 1691221 tgatttcagc aacttttgga gggcttctct ttggatatga caccggagtt ataaatggag 1691281 ctttaccttt tatggcaagg ccagatcagc ttgatttaac acctgttaca gaagggcttg 1691341 ttacgagtat tcttttatta ggtgccgcgt ttggagcgtt gttatgcgga agattggctg 1691401 atcgatatgg ccgccgtaaa atgatcctta atctttcctt tttatttttc ctggcatcac 1691461 tgggaacagc gttagcacct aatgttttca tcatggcggt ctttcgtttt ttactggggc 1691521 tggctgttgg aggagcctcg gcgatggtgc cggccttttt agcagaaatg gcaccgcatg 1691581 aaaagagagg gcgtatggta acccaaaatg aactaatgat tgttggcggg caatttttag 1691641 catatgtttt taatgcgatc ctcggtgtaa caatggcaaa tacgggacat gtttggagat 1691701 acatgctagt catttgtgct gtaccggcta tcatgttatt tgccagtatg cttaaggtac 1691761 cagaaagccc ccgatggcta atctccaaag gcaaaaacag tgaggcgctg cgagttctta 1691821 aacaaattcg agaagataaa cgtgcagaag ctgaatgtag agaaattcaa gaagcggtag 1691881 aaaaagatac agcactagaa aaggcatcac tcaaggactt ttctacacca tggctgcgcc 1691941 gtcttttatg gattggaatc ggtgttgcca tcgtgaatca aattacaggt gtgaactcga 1692001 ttatgtatta tggcacacaa atccttaaag aatctggttt tggtacaaaa gcggctttaa 1692061 tcgctaatat tggaaatggg ctgatatcag ttattgcagt tatatttggg atttggctgg 1692121 tcggaaaagt gagacggcgt ccaatattat tgattggttt ggcagggacg actacagcgc 1692181 tcctattgat tgcgattttc tcaattgtgc ttgatggatc tatggcactt ccttatgtag 1692241 tgctttcttt gaccgtttta tttcttgcct ttatgcaagg gtgtgtagga cctgtgactt 1692301 ggcttgtcat agcggaaata ttccctcaaa ggttaagagg acttggttct gggataagtg 1692361 tttttttcct ttggatatta aactttgtga tcggttttgc tttcccgatc ttgcttagct 1692421 ctgtaggttt gtcttttaca ttctttatat ttgtggcttt aggtgtattg gcaatcggtt 1692481 ttgtgtacaa attcatgccg gaaacaaaag ggcgtacact tgaagaatta gaagagcatt 1692541 ttcgttctcg acacgatcat aatactcctg aacaatcagt tattgaggta taaatatgtt 1692601 gaaaatctct cttcttatag gagggatttt tttagtttca gaaaaaacaa aatccctctg 1692661 gtagagggat tttgattcag cattttaaga tgttctacac gtataatact ggagttgata 1692721 ctttaaaaat ctcgccatct cttatataaa aacgagggat gcggcggctt aatgtagaca 1692781 cgacttcata gttaatcgta ttgagcattt cagccacttc atcaacggaa atctcggctc 1692841 ctttttgctt accgtaaatc acgacttcat ctccttgttt accttcaccg ttttctccta 1692901 aactgaccat gatcatatcc attgttactc ttcccgccac tggcactcgt tttccgcgat 1692961 gaagaacaaa cccgcgattg gaaagggcac gagaatagcc gtcagcatag ccaatcggga 1693021 gtgtagcaat tacttcatta ggttctgcga tgtatgtagc accatagcta acggttcggg 1693081 gttctgtccg catggttttc acataagcga tgcgtgcctt taaacttaac gcaggttcaa 1693141 gcttaacgag atttagttgt ttaatatagg ctgaaggata taaaccatat aagccgatac 1693201 ctaaacggat catatcagcg ctaaattccg gaaatgcgat agctgcagcc gtgttgcaca 1693261 tatgcacggt gggcagctca atcccctgtt tttttaaaaa gctgagaaaa ctgatgaatt 1693321 tttcatgctg cagctttgtg agtgttgtgt ccggttcatc agctgtcgaa aaatgtgtga 1693381 aaatccctgt ccatctgagg aatttacttg cctttaaggc tttcactacc tctaaaagtt 1693441 cttcctttgt gcgtacacct aatcgtccca tgccggtatc cacgttaata tgaatggcca 1693501 gccggttagc actcgcttct ttttccaata tctcgtttgc ttctttcatc caatcaacct 1693561 gaaatgctga taatgttata ttccaagctg ctgacttctt tacacaacta agggatgtaa 1693621 aaccaagcac aaggataggt gctgtaatcc cagctttacg taaaacgatt ccttcctcca 1693681 cactggcaac agcgagctca ctcgccccgt gttccagtgc atggcgtgcc acttctatag 1693741 acccgtggcc ataaccgttc gcttttacaa cagccataat tttgctctta tgtggaatat 1693801 gacggcggat cgctcgcaaa ttctttttaa cggcatcaag attgacttcg atccaaactt 1693861 ctcggcaaag ctttatcatc aacgcttcct tccttcttat ggattataaa taccacctat 1693921 tgccgcaaga ataaatgtta attgttggat gattcgatct tattttattc aactttattt 1693981 gaaatcattc aacagcaaat ccatgtgata cgagaaggtg cctatcaatg ttcgaataat 1694041 agcaagtacg ggatacatga ggcttgtaag tggggtgtta atggatgcgg cgaccgagga 1694101 ttacaaaaat gattatttgt tttgggacat ttttttctaa gggtagatga taacgagaaa 1694161 tctaatcagg aaatacttac cgttgttatg aacattgaag aaccttttaa atgagaaggg 1694221 ctgaggaaat tctgtaaaag ataatcggtt gaaaaggcag tcgattcctt gttccataaa 1694281 cctaacatca gagtatataa ttatactcgt attcacaaaa atcgtttaag taaggggtat 1694341 acatgaatag gggagttagt tttcaaatac cgaatgaata tggaaatttt ctatggagaa 1694401 tactgcagcc ggtagaaata gctaattata ggtggcaaac gagtggggaa tcttattttg 1694461 ttgtagaagg agagctcgat gatgaggagc tttttcatga ctacgaaatt gttgaggggg 1694521 cagtttttga gcaacaatta aaaacgaatc agtactatac cattttcgtt gaactgaaag 1694581 catttccata tggaaaaatg gttaatcaag tcaatacata tgaagagttt gctgacagtg 1694641 attgcgaact tgtccttttg atagcagata atagctacgt ttcgatttac tgtaaaaaca 1694701 aaaatatcat tgaaaaactt tacttcaatg ctttacagca tgattttgaa gacgttcaat 1694761 ttataactga tgaaaatgac acaagaacaa gccttactgt atgatactca ataaaaatta 1694821 aaggagctag tacatgacaa tgcaaattaa aatcaagtat ctagatgaaa cacaaacaag 1694881 aatcagcaaa attgagcagg gagactggat tgatcttcgg gcagctgaag atgtaacaat 1694941 caaaaaagat gaatttaagc ttgtcccatt aggtgttgca atggagctgc ctgaaggtta 1695001 cgaagcacat gtcgtccctc gttcaagtac atataagaac tttggcgtta ttcaaacaaa 1695061 ttcaatgggt gttatcgatg agtcatataa gggagacaac gatttctggt tctttcctgc 1695121 ttatgcattg cgtgatactg aaattaagaa gggtgatcgt atctgccagt ttagaatcat 1695181 gaagaaaatg ccggcggttg aattggttga agtcgagcat ttgggaaacg aggatagagg 1695241 aggactcggt tcaacaggta cgaagtaaac aaaataaatc cttggctgtc ttcatgctgt 1695301 gtgattgatc aatggaggtt tcagccaagg tacatataaa tattatgtat aaaatgaata 1695361 ttttaatacg aaggatttaa ttaaaaacaa agtttaaaaa gggaagtttt gaaaaagtga 1695421 aatagtaata actaaagtcg ataaagaacc taaagatgtc aaagaaacaa tttttctggt 1695481 gctttgcttt tttgaaggtt tacttagctc gtggataact gccccccata aaagcatgga 1695541 tgctaaaatt ataatactta tatacataaa gatgctcctt ttattatatt tacagttttt 1695601 acatttttat cgattttacc acatttagga ttgagttgtc gatgaaacaa gcatctctat 1695661 aaagaaatac ttttatctaa atttttataa ataggggaag gcaactaaaa actagtaatg 1695721 ccactaataa taagccaagt taaatgactt gtgttcatta ataattgaat tttacagcag 1695781 ccatgagcac aaaaaaatct gagttcgtcg ataaatatca taaaaaagcc cccggtatgt 1695841 cgccagggaa taaatagacg tttaagagat ttagtgatgt tttttatatg attcgacaaa 1695901 atcataataa tgatcatcgt catcataata ctttttttcg taatgataat cgtgatcatc 1695961 gtaatacttt ttatcatggt catcatactt tttgtcgtaa tcataatgtt ttttatcatg 1696021 atcataatac ttgtcgcaat cataatgctt cttatcattg tcgtaatact ttttgtaata 1696081 tgtttttttc caagtataat actcttcttt atatttttta taataaccca attaaattcc 1696141 tcctttatgt tattcgaatt taatttatga agtttaaatg atatggtatg gtcaaatgaa 1696201 ataagaatag taaaaagagg ctgtttaaaa cactttctga aaaacaaaac ggatagctgt 1696261 ttatgaaaat aagagcgaga gagagcactc aatcactgta aaataatagt aaagtgtata 1696321 gagagattag tatacgtaaa aagggacttt ctcattgaag aatatttgaa cgttatggtt 1696381 aagattcaag agctctatga tgtgattttt cacactgctt ttgaaggatt tagagttaga 1696441 catcaaaaac aaacagcaaa accggctaga aacagatcat ataaggaatg aaccgctgcc 1696501 aaatatcata aaaaagttgt taatgatcaa atgaatgaaa ttagagagaa tttattttaa 1696561 agaaagccca attgcacatg gacaaatgac aattgatatt gaggtaaaat acaatgcatt 1696621 aaatcagaaa aagctattgg aggatttaat gtgtttagac aatttccaat ttggtataca 1696681 caaacacctg actatttgaa tttttatgta ccgcaatatc aaaccatttc gtataatcct 1696741 caacaatgtt atcaacggtg tatgtaccaa actggcggta actatgagct atgtgacaga 1696801 ctatgttatg gagaaataca ggtgtaaaag agggggatta actcctcttt aaacacacag 1696861 tgagtggaat aagatcctca ctttatctgc aagtgcttag tatttgcgat aatattgcat 1696921 tcgtaataaa ttatgcttag caactgaaaa tgaaagaagg atatgaatag tcatgacgca 1696981 attcgataaa caatacaatt caattataaa ggatattatc aataatggaa tctcagacga 1697041 agagtttgat gtaagaacca agtgggactc agatggaaca ccggcacata ctctaagtgt 1697101 aatcagtaag caaatgagat tcgacaactc agaggttccg attttaacga caaaaaaggt 1697161 tgcctggaaa acagccatta aagagttgct ctggatttgg cagctgaaat ctaatgatgt 1697221 taatgattta aacatgatgg gcgtccatat ttgggatcag tggaaacaag aagacggaac 1697281 catcggacat gcatatggat ttcagctggg gaagaaaaac agaagtctaa atggagaaaa 1697341 agtggatcag gtagactatc ttcttcatca attgaagaac aatccatctt cacgcagaca 1697401 cattacaatg ctgtggaatc ctgatgaatt agacgcaatg gccttaacgc catgtgtata 1697461 cgagacacaa tggtacgtta aacatgggaa actccacctt gaggtaagag cacggagcaa 1697521 tgatatggca ttgggaaatc cattcaatgt attccagtat aatgtgttgc agcgcatgat 1697581 tgctcaagtg actggttatg agcttggtga atatatcttt aacattgggg attgccatgt 1697641 gtacacacgt catatagaca atttgaaaat tcaaatggaa agagaacagt ttgaagcacc 1697701 tgaactatgg atcaatcctg aagtgaaaga tttttatgac tttaccattg atgatttcaa 1697761 gttaatcaac tataaacatg gggacaagct tttatttgag gtagcggttt aatgctgcct 1697821 ttttattgtg cagtgaatag atagcaggta tcctaatttc attaagcaat ctggaagatg 1697881 aataaaaatt gaaggacaaa cacgtataat acataaaaaa gattaactct acagttaatc 1697941 ttttttattc agaagaaaat atcctaactt tgaaactaaa tacaaagtaa aagcaatcat 1698001 tacagttcta gatattacaa ttccatgaat agctagatca tatccagcag gtatcaacgc 1698061 atttgtatta cacataaaat atatagatat tagaagtgct acaataacta aaatcattcc 1698121 aaaaagactt gttttttcat atttcatacc aatttccacc cttattaaag ttaggtttaa 1698181 acaaaagagc tgaagaaacg aactatgacc agtatgctcc aaggaaaacc gccagacaat 1698241 gctggcggct ttttgctgct tcgtttattt attaacagag atcgtaacgt tatttcctgc 1698301 aactgaaacc tttgcgaaat cctgtgtatc taccacagga gtgacggctt tattgtcgat 1698361 agtgatgttg ttaaaagagg tcgaaaaggt tgctttgatc gcatcacgct ggctttcata 1698421 cgaaacagcc gcggtagcaa gtgttttcca ttttgaaatc gtgccgatgt tggttccttg 1698481 aatttctgtg ataatccgtc cggtgtagcc gtcattgttc gttccccaaa gggtcatgcg 1698541 cgtattgccg cttaaatttt tatagattgt catttggact gtgcttccag ggcggaagcc 1698601 tttattgtat gtgaatttgt cttttccttc gatgtacgtt tcttcatttt tggacccaac 1698661 cttcatgagg ggcttccaga cgttgtattg tttgctgtac tgaagcccga tatcggcttc 1698721 agttccgctt gttgccctaa agccagaata aatataggga gtagagaccg agtcgttgtt 1698781 tttgacagtt tcaggaagca cgattttagc tgtaaaaacg gcgcccgtac tgttcaggta 1698841 gacacggccg ccgattccgt taggcagctc ggatgctgct tttgcgactt gagcgtctgc 1698901 cgcgggtaaa cctggtatac ctgatgaaag ggttccgaaa agaactgctg ttcctactgc 1698961 acctgcaatc aatacttttt tcaccaaaat tccccctttt gatagtggtt tcgccattta 1699021 ttatacctta ttttggaact ggatttacgt atataaatcg acaaaatatt tcattttgaa 1699081 tgatgtaagg tcgaaacgct tcgccaatct gaaagctata tacctttatc agaggaaaga 1699141 atgagatcac attcgtttta accgatttga aattttcctc aaaataaaag tacaaatgct 1699201 taaagaaacg attattaaaa gaatgcccgc tatcgtttcc aagcctgtaa aaaagaggtg 1699261 acgtttcatc aatgtctgtc cttgtaaaat gataaaagca cagataccga ctaagaaaag 1699321 aaaacaaata cttaggattg ctaacgcttt acgtgagtat gttttcattt catctttaaa 1699381 atacagcaat acgaaaataa agcagataac attggctatt gttctaatca cctcaaagct 1699441 tttcatgaca actgatataa atagacaaag taaaatgaga taaaatacga tgtttctata 1699501 caaaaaacct ctccttttat gtaggatcct caaagagttt ataaaagttt ctttgtaact 1699561 gcaataaatt gaatgcgctc acttatgaac taactaaact atgtactaaa tattcactat 1699621 tctttttcag attcagtcac caaggttttc atagaaaggg aagcttcaga aatatacata 1699681 tagtgcacaa acaaaaaaga cccggcaata gccgggggaa agtaaaaacg aggagatgtt 1699741 aatggcgttt agtagtgttt tttatgcttt ttatactcta caacataatc atagtctttt 1699801 ttatcgtgat cataatattt tttatcatag tcatcatatt ttttgtcgta atcacagtca 1699861 taatcttttt tatcatattc gtaatacttc ttataatacg tttttttgac cgtataatac 1699921 tcttctttgt attttttgta ataacccata tatactcctc ctttattttt actacgcttt 1699981 attatacggc gagtagattt tgcggcttgg acagttaaaa tcatagaagg aaaaaagggc 1700041 tgtccaaatg atagaaaaag acagatgaca caaaaacaaa tcaaaataaa gagccgattt 1700101 ttcatcggcc caaacgattt atcctacatt tgtttgtctt ctttgttttc tgagtcattt 1700161 tttctgatat cctgagtcag tccgcttgtt gcttgtttaa attctgataa ggcttttcct 1700221 gctgcacggc caagcgccgg cagtttatca ggcccaaata ctaaaaaacc cacaaacaaa 1700281 ataacgagta tttttgtgaa gcttaattcc atatcctttt ccccctgatt gaagtacaac 1700341 cttttaaaca aattataaga gatagcagta caaatgggaa tgcatttatt ttgaacattt 1700401 taaaaccagc acaaagacgg attcataaaa cggctgctgc tgaatataat gtccaatgcc 1700461 acctgcctaa gaagcaggag gcaggctgga tcaattatgt agctctgccg gaaatgatac 1700521 aaacgtagcg gctatcattg acatagagga gtggtgtagc tgatgagatt cactaaggta 1700581 gttggatttt tgtctgtttt agggttggct gcggtttttc cattaacggc acaagcagaa 1700641 aaagccggaa ctgcgggggc tggagagtgg gataagttgg ggacttacac atatacttac 1700701 tcaagtccga cggtatactc gaccggagga gattttagag tgtgcctttc aggaagcact 1700761 cctttttctg tttcactgca cttatatgag gatgatcccg gtgacaatcc tgatgattat 1700821 gtaggggcaa actatttttc acccggagaa tgccacacct ttggcagtat tggaaaattt 1700881 gtagatggga gcaataacaa ggccgagttc tttgttaccg attactctgg taaatctaaa 1700941 actgttacgt tttatgattg atggactcaa attgtgaagt ataacccttg gaaaaaaaca 1701001 aaaaagagag atacctctct cttttttatt cttcgacagc cttacgaagc cgttcattta 1701061 caatgccagt ccagccgcca tccatcttac cgcgaacgac ggagcttttc tcgtttgctt 1701121 tgccgatcac ttcattcggc tctttccagc cgctgtgaat aagggtaaac cctgtctttt 1701181 cccccaagtc ttctaattga aaggtaacga cccatccttc tgtatcccat tcaaaagaaa 1701241 gttcagttgg agcttgaaca gccaaaactt tacaagggga cggcccaaac ggcgattgta 1701301 agtgaaattc ttgtccttct ttgagctgaa agtcattggg cataaaccac ttggcaatgc 1701361 cttctgaagt agagactgtc tcccagactt tctgaatggg agcctccaga gtaatgcttt 1701421 ttgtaatatc cggtaatgca ttttcgttgt tttgagccat ttcgtttacc tcttgacata 1701481 tgatgttttt tcaattcaat catataataa ctaataagat catgtccata gcgtgcatta 1701541 tttatgctag agctgctgtt gaacagcgtg tcagtcgcca gtctgatctg tgaatgggag 1701601 aattctgcat gcgcgaaaaa gagagagagg tgtatgttgt catttcgttc attcttgttt 1701661 gcagccgcaa ctgttatgtt tgaactggga ttcctgttca gccaatttat tttgcgattt 1701721 ttgttttaat agtaaatgag ccattttcta aaacaggagg ttttttatgc ttggaaaaat 1701781 caaagcagcc attgataata gtccagggaa gccggccaga attttagtta gtgaaaaagc 1701841 gtttcagcaa ttagaggaag aaatgcgctt tgtttacgtt tccaaaccga aaacgataat 1701901 ggggattcct gtggaagttt cagatcaggc agaaagcttc aagctggaat tttagttttc 1701961 ccagactgct aaaaggctca ttttgtgtta attatgcaaa atggtcaggt tgatttcttt 1702021 aaaagcatga tgaaatgttc atcatgcttt tttattgaga aaaaagacga acataaaaaa 1702081 taggtatacg ggaaaaataa tcctattaga gagaggggaa ctgacagatg gataacatga 1702141 tatcaacact tactgactgg aatgtgtggt ttcaagcgtt agtagtattt ctcgttccat 1702201 atgtaatcta taaagtgttt acttggattc atgtataaga aggtgcaatg atgaggtggc 1702261 ggaacaatca gtacaaaaca cagaagcagc ataaatcaga ttattcgaca gctgaaaagc 1702321 aggatcagga tgtgttaacc ggtaacatcg gatacgactt agaacatgta aaaagaaaaa 1702381 taggacataa cggggacgtt catttccgtg agcttgaaat cactcaatta catgtgaaag 1702441 cggcattgat ctttgttgaa ggactgtctg atcaggactt gattaataaa ggactatcag 1702501 tgttagtcat gaatcaacct aatcaggtaa gcgatgaaat ttctcaatcc ggcaaaggta 1702561 ttttaacttc gaaacagata aaaaatcaaa tcgtatcaat cggtgatgtc atagattcag 1702621 agaaaatcag tgatatcgtg ttgaatgttt tcatgggttc gacagcgctt ctcatcgatg 1702681 gaataccgca ggcctttctt ctgggaactg taaaaaaaca aaatcgaagt atcgaggagc 1702741 cgctttcaga agcgcttgtc agagggccgc gcacaggctt tacagaagag ttgagtacga 1702801 atacagctct tttgagacag caaggaaaaa atgatcaatt aacattgcag agatttgaag 1702861 taggaacacg attaaaaaag gatttaatta tcgcttatat gaatgacatt gcagatccaa 1702921 aagtagtcga ggaagtaaga aaaagagtga gagggattga gatcgatcat ttgccggagt 1702981 caggctacgt tgaacagtta attgaggata attatttgag cccgttcccg caagtacaga 1703041 gtacagaacg tcctgatcgc gtcataagcg gattaatgga aggaagagta gctattctgc 1703101 ttgacggcac tccgtttgct ttgattgttc cagtcacttt cagcatgatg cttcaatcgc 1703161 ctgaagatta ttatgaacgg tggttcccga gctcgctcat cagattgctg aggttcatcg 1703221 cagcaatgat aacgttattc gcacccgctt tatatatatc atttatttct tttcatcctg 1703281 ggttaattcc gaccaagctg gcgatttcaa tttccgggac gcgccaaggt gttccgttcc 1703341 catctctgat tgaagcctta tttatggaag tcgcgattga aattttaaga gaggcggggc 1703401 ttcgtttgcc aaaaccaatt ggacccgcaa taggcatagt tggcggatta atcatcgggg 1703461 aagcagctgt gcaggcgggg attgtcagtc caatcatggt cattgttgtt gcgctcacag 1703521 caatttcttc atttgccatc ccgcattata gcacaggtat agcacttcgg atgcttcggt 1703581 ttggcgcgat gttttgtgcg gcggtgtttg gattgtttgg agtcattatg tattatctgc 1703641 tgctaagcag ccatgtcgta aagctaaaga gctttggtgt gccatacgca agtccggcag 1703701 tgccctatca cttaaaagat tggaaagact ttgttatcag aatgcctctt ttagtcatga 1703761 agcgccggcc taaaatgatg aatacagata atacaaaacg ggtgaagtga tgaactcgac 1703821 aggatggtga taaagtctca tgttcagccc aaccagtaaa atcacaaccg ctcaggcaac 1703881 gattatcatc attaattata tgcttgctgc cggagttctt acgctccctc ggacagtaac 1703941 agaacaaaca caatctcctg atggatggat ttcagtttta ttaggcgggg tcctagcggt 1704001 aatagccggg atgattatag ctaaattaag ccagcagtat cctaaggaga ccttttatga 1704061 atactcccga catattgtag gaaaatggct cgggcatctg atcagtattg tttttattac 1704121 ttattttctg gcactcggtg catttgaagt cagagtcatg tccgaaatcg tggatttttt 1704181 tctcctcgaa gggacacctt cttgggccat cattatgaca gttctttgga ttgggcttta 1704241 ttcaattaca caaggcctag atccgattgc acggcttttt gaaatgattt ttccgattac 1704301 ggtcatcatc tttttaacga tagccctcat gagtttaggc atatttgaga tcaacaattt 1704361 gcgccctgta ttaggtgatg gaatcatgcc ggttcttaga ggtgtaaaga caacgaacct 1704421 ttcatttaca tgttcagaaa ttatgttcat tttagtagca tttatgaaaa agccgaaaaa 1704481 tgcggtgaaa gcagttgtga tcgggacagg cgttgtgacc agtttttata tgattacgat 1704541 gattatggtc atcggtgcac tatcagttga gggagttgtg acgagaacat ggccggggct 1704601 tgacctgatg agaagttttg aaatacctgg tttaatattt gaacggtttg aatcatttct 1704661 gcttgtgatt tggattatgc agctttttgc cacgtttatt atcacttttt atgcagcttc 1704721 cctgggagtc tcacaagttt ttaaaaagaa acccctttca tgtatgtttg ggctgcttcc 1704781 tgttatatat atcctctctt gcatgccgaa aaatgaaaat gacgtcttta tattgggcga 1704841 tacggtcagt catatcgctt tgtatatatt tggcgctttg ccgattttgc tgttagtcat 1704901 ttcgaaatgg aggaaaagag gtgaaaagta aactaaaacg tcaattgcct gctatggtca 1704961 tagtatgtct gctgatgatt tgcgtaacag gatgctggag cagtcgggaa atagaagatc 1705021 tgggtctcac attcgctatc gcaattgata aaggaaaaga aacgaacact gaaaaagagt 1705081 taaaagaaga gggcgggagc tatccgaaaa aagacaacat tacgctgacc tatcaatttg 1705141 ttaatgaaaa agcggcaggc gcgggcacaa gcgggggagg cggtagcgga caaggagcgc 1705201 aaaaagcgta cattaatata agtgaaacag gggattcatt acagcagatc ggaagtgagg 1705261 ttgcattaag acgggaccga gaagtgttta gcccgcattt aaaagttgtt gtcatgagtg 1705321 aagatgtgct gcacacattt cctatcgacg aaatgctgga tcaatttttt cgtgataatg 1705381 aaatcaggct gagctgtctt gttttatctg ctaaagggga agcaagagac gctctccagc 1705441 tgaaagagaa cggagaaatt ccggcatttc ggctgattgg attaggtgaa aatgaacata 1705501 aagtttccag aattcttccc cctatgacac tcgcgaaact aattggaaaa ctgcattctg 1705561 gcagcagctt tttactgcaa aatgtggttg cggcgaatgg agcggtcaag tattccggag 1705621 cagctgtaat caacggaaaa tcgaaaaaaa tgataggcac cttaaatgaa tatgaaactg 1705681 aggggattac atggattaga ggagaaggga aaggcggagt tgtcaaaagt catgataaaa 1705741 agagccaaca gacgttagcg tacgatatca ataaaatcaa aagcagaatt cagccaatcg 1705801 taaaagggaa agatatttca ttccatgtcg atattgaatc agaaggcgat ttggttgaaa 1705861 actggaacac aaaagaggcg ttggacaccc agtttataga tcgtctcgaa acgactattg 1705921 aaaacgaggt aaagaaaata gttggtcagg tattaaaaaa aattcagcat gattataaag 1705981 cagatgttgc gggttttgat gaatctttta gacttacata tcctcactta tggaaaaggg 1706041 tgaaaaataa ctgggatgac accttcagta aagccgacat cacatacagt gtgaacgtca 1706101 caattactca tttcggcacg gttaaaactc agtaatgaat cccaaggaag agaaggaaac 1706161 ctctcttctc ttttttatgc atttattagg ataaagatac tttttttgga gagatataca 1706221 cttttcaaat cgaccaatat gctaatatag gaattgcttg aaatagaagg gagaaggggc 1706281 tgtgaggcag aaaccgattt atgtagaaat cgaaatgaaa tctgatctgg atacactctg 1706341 ggaatataca caaaacccat cactgcataa ggaatgggat ctccggtttt caaatattac 1706401 gtatttgaat agtcagccat gcgaaaaaca gaagtttctt tacgaaacaa gggtaggctt 1706461 tggattaaag gtgtcaggta caggagaaac cgtcggtgtt ttcaacaaat gttcatctga 1706521 aaggtcttct tcactggctt ttggctctga tcatccatta tctctgattc ggcatggaag 1706581 cggctactgg aagtatatac agagagaaaa tgggaaaatg acgtttttaa cacagtacca 1706641 atacaaaaca gcctacggac tgctgggaag atggattgat cgtttattat ttcggccgct 1706701 gcttggctgg gcgactgcct ggagctttga tgcattaagg ctttgggtag agcaaaataa 1706761 acatccgaag cgcttcattc gatctgctat catctatgtg ttcatgtgtc tgtttttcag 1706821 cctgttttgg ttctatcaag gctttgcagg tgttaagaca agcatattga caggaacagc 1706881 ggagataggc ttagctattt tgtggctgct tcctttaaaa agaaaatgga tcattcatgg 1706941 tgtccaggct tgtatttttg ctgggtttgc ttgtctaggt tccgaaatat tcatgtgggt 1707001 tctattgagt gtgttttccg ctgcaagcgg cgctcttagc ctgcagctcc ccagtgccag 1707061 gcgcacaaaa cgaaagagaa agaagtgaca ttgtgagttc gatttatgaa aaatcaatta 1707121 ttaactatca tttgctgcat cccaagctgc agaaacggta ccaattagac gggtctcata 1707181 cattcagcgg gacgggaacg atgtcagaaa taagcggagg ctcttttctg gttagaatgc 1707241 tgttaaagct gggtgttttt ttcagatgct tcttttcaga aagaggcaaa gacattccat 1707301 ttacaataca aaatagaact tgtcttttga aatcgcaaca tacaggaata gaatggaatc 1707361 gtacattttt ctttaaaggc aaaaaacgtt tctttgatgc gttaatgata tatgacgaga 1707421 aagaaaatag aatacttgat ttcttcggca aacctcatct gctgctgtct gttttgacgt 1707481 tcgaggcatc tcttgacggc tctcttacga tcacatcggg aaagcaatgg ctattgatat 1707541 gcggaaaaag aatcccgctg ccgaaatggc tgaccggtac atccgaagtt tgcgaaacgt 1707601 ttgatgaaaa aaagaattgt ttcaccattg aagtgcatgt gcaaaataca attcttggca 1707661 ctcttttctt ttataaggga acgtttcagg aggaagagag agaatcatga aacgaaatgg 1707721 catagtcagt gcgctttgtt ttattggatt tcttgcagca gaagcaccgg atatttcagt 1707781 ggcagaggca ctcgttttgt tatccattct atttttcgtg ccgggaattt ttccttttgt 1707841 ttttcgtcaa tctccggttc gtgctgctca gtttatggaa aacgggctaa tccagtgcta 1707901 tcctgtagcc gcattctttg cggtgctggc tctagtgacg gaggttgggg gtttcgcact 1707961 tatctggtgg atgtacacag tttttaatgc attgtatgcg atcctccgcc tttgggaaac 1708021 aaagatacat agaatcgaag agacatcagt tttgttcggt cttatttatt tggcgggagg 1708081 aggattttgg ttttttgctt atgctgccca tttgcagatc atgcaatttg gccctctcat 1708141 cattttgctg actgctgtcc actttcacta ttctgctttt ctgatcccga tcttcaacgg 1708201 tttactcggc agaaccatta gaaaacatcg gatgttgtac agttggataa catgggtgat 1708261 tttgctttcg ccccttctta tcgcactggg catcacatat tcaaaaacac ttgatgtcat 1708321 tgcggttagc atttatatgg cggcgattta tcttcatgca tttttggtgt tcacggcagc 1708381 ttttcgcacc aagacgggga catttcttat tcggctttct tccgctgttt taatgataac 1708441 gattgctttc tcgatgattt attcatttgg tgtctttcgg caagaagtta cattgaccat 1708501 caatcagatg atttggattc acggttttgt caacgcgttt ggtgttatct tgcccgctct 1708561 catagggtgg agaatagagg atgcgaaacc ttttgatgca gacagtgtaa agacattcag 1708621 ccgtatctac ggaaaaagaa agattggaga agaattttta gctaacattc aagctgaaaa 1708681 taacgctcgg tacagcggac ttgtggatga tatgggcagc ctgcgttcaa aagatttttc 1708741 accagaaaaa ctggcgccgc tcattctttc gttttatgaa caaaccatcg aatacaatat 1708801 taaagcaaaa gtaacatgga gcacgtggtt tcggccgctt gcaattattt acgaatggtt 1708861 cagcagaaga atcggccaaa tacatctttc gacgaaccct gactggtata ggatgtacag 1708921 caagataaaa ggtgttcatt cgaaaaaaga cggaagggaa agagtacgtg cctggattag 1708981 aacaaatgaa aaaaacgaaa ccatttttac cgctctttat tcagtgtatc gttcaaatgg 1709041 agaggggtat atgaatattt ctttaccgct tccattcagc agcatgacag gtattttaaa 1709101 accatatcat catcaggaga agctggtttt aacaagcagg cggagaaaaa gcagagcggg 1709161 ggatgagggg atttatctgc aaacaagagc gggaacttgt ccgcttcctt tatctgaaac 1709221 ctttctgata gaagctgtac atgacaacaa attaaccgct gttcatcata tgtggctgtt 1709281 tggaataaaa tttctaactg ttcattacag cattacacat attaaccagc ctattgaaag 1709341 aacctaacac aaagaagaag cttcgtctgc cagttgtaat gagatgaact gttttaaaat 1709401 tctgcaccgc atcaagacag gaaaggaagg gtttatggtg ttttatatca gtttatttct 1709461 gattctttgg ctggctgctg ggtttgcagt gggaatgaaa caagtgtatg tcgatcagct 1709521 gtttgataaa gctgtgatcg aaagactgga aaaagaagcg aatgatcatg gacatgctga 1709581 ccggatgatc aaacagcgcg tcctttatat tgcagcagtg acagtaagcg ggtttatttc 1709641 tgtttattat gaaatgaaaa caatcccgca aaggcgaaac ataagaaaaa ttgaaaaaaa 1709701 catcatgaaa ttaaatcaag caaaaaaacg aagaatgaag agaaaataaa aagtgcacag 1709761 gccaaagggc aggtgcattt ttgttttgta tggaaaatgg gggaggtggt gccagcttac 1709821 ttttcataaa ttcaaaaatg agaagaacag cgcccgggct aatggtatat aatattgtga 1709881 atttaacaaa aatttaacaa ggaggacgag agaattcgtg ctaaagcctc aaagagacct 1709941 acattctgtt gatttggact tagaggcgga gtagatgaaa ccggccaaag tatccctgct 1710001 ccgccgtttg ctccattcct tgaagcatgt tgattgtaac atagccaaac gttttccatc 1710061 aactattaaa attgtaaaat tattgatgat ttttatggtg tttactccga tttcttcaat 1710121 ttatgctgaa gatgtatatc agaattttga ggaattaaaa aacaatgaag atccttctga 1710181 ttatggcgtt gttacgaaag aaaccggaag ccctgttctt gttttagcta ttcacggagg 1710241 aggtattgaa ggcgggacaa gtgaagtagc gagagagctc agcaaagagt actcgatgta 1710301 tttatttgaa ggcttaaaat cggcaggaaa ctcagtcctg cacattacga gcacacactt 1710361 tgatgaacct cgggccctta aaatgacggg aaatcatgaa tatgtcattt cattacacgg 1710421 gtacgcagaa gaagatcagc agatcgaagt cggcggtaca gatcgcgtaa gagcggcaga 1710481 tttagttgag aaattgcagc atgccggttt tcctgctgta ttgctcaata tggaccatcc 1710541 gcatgcgggc gttagtccga ataacattgc aaataaatca aaaacaggtt taagtattca 1710601 gatagaaatg agcacagggt ttcgaaagtc tttgttcggc atcttttctt taaaaagcag 1710661 agctgttact caaaatgaga ggttttatga gtttacagaa gtgatgttcc gttttctcaa 1710721 aaatagctac tgaaaaatag gaggcgataa gacagcctcc tattccttat gcttctcttt 1710781 cgtttcggga aacagctcgt ccgcggcttc cgtttgatac tgcaacgtgt tatctctcgc 1710841 tgacagttca tttcggaaat tttcatcaag cacatttttc agtaaatacc gatgaaaaaa 1710901 gtattcaaaa acagtaagac aggcagcgga aaggagagcc gctccaaatg gtgagaaatc 1710961 gtttcttgtt tgggttaaaa caaataccca aagaataacg aatgaaaggc caaagtcagc 1711021 caatgaagct gtaatattgt ttgttctggg taagacgagc atgtcaccag aaagatagga 1711081 aacaaaacct aagaaaagtg caataaacat cacacttaaa aaggatgcgt gatagactct 1711141 gtccaaaatc acatataaaa gggcgagagt gaaagcaatc tttgaagcaa gcgcaatgat 1711201 atgtttcatt tgaccaccta aattgttatt ttttgaagaa aattcttggg cgtaaacaaa 1711261 tgataaataa tgcaattcaa aaccattcat aatggtcatg ttactatttt aaacagtccg 1711321 tttttgttta cactggtatt tttttcagct gtatgaaact ttcttatgaa aaaagtcgta 1711381 tatgtggatg atcagctttc aaggggggaa tgatttgtgg agataaaagg aatcaatcac 1711441 ttgctatttt cagtttcgca tttggataca tcgattgatt tttatcaaaa agtgtttggt 1711501 gcaaagcttt tggtaaaggg aagaacaact gcatattttg atatgaacgg catctggcta 1711561 gcgcttaatg aagaaccaga catcccgaga aatgacatta agctttctta tacccatatt 1711621 gcttttacaa ttgaagatca tgaatttgag gagatgtcag ctaaattaaa aagacttcat 1711681 gtcaatattc tgcctggcag agaacgagat gaacgcgatc gaaaatcaat ttattttacc 1711741 gaccctgacg gccacaaatt tgaatttcat accggaaccc ttcaagacag gcttcgatat 1711801 tacaaacaag aaaaaacgca tatgcacttt tatgatgaaa cggccttttg atagcacaac 1711861 catatttcat ataaggttaa atttaaagaa gggtgttggt ggagacttta tgtttgggga 1711921 aggtttctac ccgacttgtt caacgatgcc atatcttttg aactgcacaa gtgattgggt 1711981 gaaggtgaaa ttgaaataca cattacatta cattttatat gaagaaagcg agctgtttta 1712041 tcaaatgttg aactaattaa actatgtact aaattttcag tatatttcaa ttgctttgcc 1712101 ccttaataaa tataaaaccg catccttcca cgacctaaaa aatgaaacgt ttttaagaag 1712161 atggcgtcta atattctaaa tgttcatatt ttgataaaag tttcctaaag gaaagaaaat 1712221 ttcttgactt caacaatctt ttggtggata attatggtgt aaacatgatg ttctttttcc 1712281 tcctattcgg gctcgcaccc aaaagtcagg gcgagcctgc tttttttgaa caacaaaccc 1712341 cctctccgta aaggaagagg gggttatttt atgcatctga tagatcaata gattaatgga 1712401 cggttctgaa cacgccaatc actttcccta gaatgctgac attctgcaaa atgataggtt 1712461 ccatcgttgg gttctcaggc tgcaagcgaa tgtgggtatc ctctttatag aatcgtttta 1712521 cagttgcttc atcatcttct gtcatcgcaa ctacaatttc cccattgttc gctgtgtttt 1712581 gctgtttaac gatgacatag tccttatcga gaataccagc atctatcata ctgtctccca 1712641 taatctccag cataaataca tgctcgtctg gaggaaccat gcggtcaggg agcggaaaat 1712701 attcttcaat attttctact gctgtaatag gagatcccgc cgtgactttc ccgatgaccg 1712761 gtacattaac gacctggctt tgcggaatgt ctacttcttc atcaagaatt tctattgctc 1712821 ttggttttgt cggatctcgt ctgatcagcc cttttgtttc caaacgggcc aaatggccgt 1712881 ggacagtaga actggacgca agcccgacag cctctccgat ctctctcacg gaaggcggat 1712941 atccttttga tttaacctct gctttaataa aacggaggat atcaagttgc ctttttgata 1713001 gcttcgtcat ttttcgcacc tcaaaacgtc gattttaaga agattatagc atgattttcc 1713061 ttacagtaca aacataggtt cgaaaaaaca attgacagaa acgtttgttc gtatatactg 1713121 aaattataaa aatgcgaaca aacattcctg ttggaggtta tgatcatgag taaagaatct 1713181 attatttttg tcggtctgtt tacagtgatt ttgagcgcgg ttatccttat gctgtcatat 1713241 acaagcagcg gccaagagct taatcagtat gttaaaatag aagtccagca aggcgacaca 1713301 ctctggtcaa ttgctgatca ggtagccgat acaaaaaaga taaacaaaaa tgattttatt 1713361 gaatgggtag ctgataaaaa tcaacttcaa acctctgata tccagccggg tgatgagtta 1713421 gtgatcccat tgaaaaagaa gcatcaggat gcatatgaat tagcaactgt aagatagaga 1713481 ggaaagagag ataaaatgaa agcactcatt tatgcccgtg taagcacaaa taaagaacag 1713541 caggaaacgt cattaaagcg gcaggaggag gagcttacgg ccattgcagc ggagaacggc 1713601 atggaagtgg tcaaagtgat ttcagaaaaa gccagcggat atgaaatgga tcgggatggt 1713661 gtatttgagc tgctcgatga gattaagaac gctgatattg atgtcatttt ggttcaggat 1713721 gagacaaggc tcggacgggg aaacgcaaaa atcgcactgc ttcattgtat ttatagagaa 1713781 ggtgtgaaag tctatacaac ggctcataga ggtgaactgg agttatcgga ggctgactca 1713841 atggtcttgg aaatcgtcag cattgtggaa gagtatcagc gaaagattca caacatgaaa 1713901 atcagacggg gaatgaaacg tgcagtaaaa aacggtttta aaccgcaaaa aaacttaaaa 1713961 aaccaacatg ggaacagtgg aaaagaaaaa atagaggtgc caatctcaga gatcgtccgc 1714021 ctgagagcga ataaactgac gtttgctgaa atcgcggcta ccctaagagg gtttggctat 1714081 gatgtctcta aagcaaccgt tcaccggcgt tttcaggaat acatagagaa tgaagagact 1714141 gcagagtgaa tcagttgtaa aacttttttt gatctagtac tatatagaca aaatgcaata 1714201 aaggagttta acatgatttc aaacgcgaaa attgccagaa ttaatgaact tgctgccaaa 1714261 gctaaagctg gcgttattac agaagaagaa aaagccgaac agcaaaagct ccgtcaagag 1714321 tacttgaaag gttttcgttc ttctatgaag aacacgttaa aaagtgtgaa aatcattgac 1714381 ccagaaggca atgatgttac accagaaaag ctaaaaagag aacaaagaaa taacaaactt 1714441 cactaatata agaggaatac ggcaatatcg tattcctctt ttgcatatac tataatcaaa 1714501 actcttatgt gacaaaattc aacaagtttc tctcaaattt aagctgaaac agttgagaaa 1714561 aagtcgtcag acatttatga tgtaagggta caacacataa ggaaggggat ttttatggat 1714621 acaattgaaa agaaatcagt tgctaccatt cgcacactgt caatagacgc tattgaaaaa 1714681 gcaaattctg gtcacccagg gatgccgatg ggagccgctc caatggcata cacgctgtgg 1714741 acaaaattta tgaacgtaag tccggcaaac cctggctggt ttaaccgtga ccgttttgtt 1714801 ttatctgctg gacacgggtc agcactatta tacagcatgc ttcatttaag cgggtttgat 1714861 cttagtattg aagatcttaa gggattccgc cagtggggca gcaaaacacc aggacatccg 1714921 gaattcggac atactgccgg tgttgatgct acaacaggtc cgcttggcca aggaattgcc 1714981 atggcagtcg gtatggcaat tgctgaacgc catttagcgg aaacatacaa ccgcgattca 1715041 tttaacgtag tcgatcatta tacatacagt atttgcggtg atggtgattt aatggaaggt 1715101 atttcttctg aagccgcttc actcgcaggc catcttcagc ttggccgtct gatcgtacta 1715161 tacgattcta atgacatctc tcttgatgga gacctcgacc gttcattctc tgaaaacgtg 1715221 aaacagcgtt ttgaagcaat gaattgggaa gttctttatg ttgaggatgg aaacaatatt 1715281 gaagaattaa cagcggctat cgaaaaagca cgccaaaatg aaaagaaacc tacattaatt 1715341 gaagtgaaaa cgacaatcgg attcggttca cctaaccgtg ccggtacatc cggtgttcac 1715401 ggtgcgccgc ttggtaaaga agaaagcaaa ttaacaaaag aagcttacgc gtggacatat 1715461 gaagaagact tctacgttcc gtcagaagtt tatgagcatt tcgctgtagc tgttaaagaa 1715521 tcaggtgaga aaaaagaaca agaatggaat gctcaattcg ctaaatataa agaagtttat 1715581 cctgaacttg ctgaacagct tgaactggca atcaaaggag agcttccgaa ggactgggat 1715641 caagaggttc ctgtgtatga aaaaggaagc agtttggcat cccgtgcatc ttccggtgaa 1715701 gttctcaacg gacttgcgaa aaaaattcct ttctttgtcg gaggttctgc tgacctagcg 1715761 ggatcgaaca aaacgactat taaaaatgcc ggtgatttta cagcggttga ttactcaggc 1715821 aaaaacttct ggtttggtgt acgtgaattt gcgatgggtg cggccttaaa cggtatggcg 1715881 cttcatggcg gtcttcgtgt attcggcgga actttctttg tcttctctga ttacctgcgt 1715941 cctgcgattc gccttgcagc gttaatgggc cttcctgtga catatgtctt cacacatgac 1716001 agtattgcgg ttggtgaaga cggtccgacg cacgagcctg ttgaacagct tgcttcactc 1716061 cgtgcgatgc ctaacctttc tttgatccgt ccagcagacg gcaatgagac agcagcagca 1716121 tggaagcttg cagtgcaaag cactgaccac ccaacagcgc tagtgcttac acgtcaaaac 1716181 cttcctacca tcgatcaaac atctgaagaa gcattggcag gagtagaaaa aggtgcatat 1716241 gtcgtttcta aatctaaaaa cgaaacacct gacgctcttc tcatcgcttc cggatcagag 1716301 gtaggtcttg caattgaagc gcaggctgaa ttggcaaaag aaaatatcga tgtttctgtt 1716361 gtcagcatgc cttcaatgga ccgttttgag aaacaatctg atgaatacaa aaacgaagtc 1716421 cttcctgcag atgtgaaaaa acgtcttgca attgaaatgg gctcatcatt tggatggggc 1716481 aaatacacgg ggcttgaagg tgacgttctc ggcatagacc gattcggtgc atctgctcct 1716541 ggtgaaacca tcattaacga atacggcttc tcagttccga acgtagtgaa tcgagttaag 1716601 gcattaatca ataagtaagc ttttgaaaga ggatgagtca aatcatcctc tttttcttgt 1716661 ttatccgaca aaaatagtat tggctgttta acagtaatag acaattcttt cttttcttct 1716721 tttgtataat agagagcaaa tgaaatgctg ctggaaaagg ggatgaaaag atggaacgtc 1716781 actactatac gtacctgatc aaagaggaat ttgccaatca ctatttcggc cgggaatcgg 1716841 ttatgtttga gctgtttcaa gactatcatt ggacaagcct tgaaaagcag cagtatgaaa 1716901 tgacagagaa acagattcaa tatattacac aaccaatccc gattttacat atgcatcagc 1716961 ggttaaaaat gaatttaaac aagacggatt acaggcagct ggattatatt tatagaatag 1717021 ctttgccgaa agcaaaaggc cacgcgacgt ttatgatgaa ggagcacatg atagaaattg 1717081 tggcttcggg agattacgag gcagaaacga tattctttga agtgttaaga aaagtaagcc 1717141 cttgcttttt agcaatggat ttcaattcga agcgttacgg atggctaaat ccggtgaaag 1717201 aaagaaattt tgtctaaaac cgaagaaaaa gagatgtaaa tgttgtataa tagcttttgg 1717261 tttagtacac tttaaactag acaacatgaa ggaggaaata aaatgacttt atgggttggc 1717321 atcctagtgg gcgttgttgc attgctcata ggtgttgcac tcgggttttt tattgctcgt 1717381 aaatatatga tgagctacct gaaaaagaat ccgcctatta atgaacaaat gttacgcatg 1717441 atgatgatgc aaatgggaat gaaaccttct caaaagaaaa tcaatcaaat gatgaaagcc 1717501 atgaataatc aaacgaaata atacgtaaag attatgatat agagaaacat ggttataaaa 1717561 taaaaaaccc ttatacgggt tttttatttt gcaatcattc atcacccgct actgctcgaa 1717621 ggcgctgctt ttgatattgt atgagaagat ggtcaagctc ctgactgagc tctatcgtaa 1717681 tatgagatgt cattccgttc gccatgacaa tttgcagcag ctctgctctt tttttttcaa 1717741 tttcttttaa tagatgctct ctaatcacag ggatgtatcc tttcatacat tagatcttca 1717801 aagtgaatgt ttatattata tccatattta tactaatttt caaatgagaa ggagtataat 1717861 gtctcaatgt caaattaaat tatataagtt ttttctgaaa atagaaatcc ttcaagtgaa 1717921 agtgttaaaa aaatgaaatg attttgtcat aacttgaagg aatgtcaaat catgaaggga 1717981 tgatgacatg ggagacgtga attatttttt gacattcgga gcggggtttt tatcctttat 1718041 ttcgccttgc tgcctgccgc tttacccagc ttttttgtca tatattacag gggtcagcat 1718101 ggacgatgta aaaactgaaa agctgctgct gcagaaaaga agcttgtttc atactttgtg 1718161 ttttttgctt ggcttttcag tcatttttat tgctttaggc tatggaacat cttttattgg 1718221 cagcctgttt agggattatc acgatgcgat tcggcaaatt ggcgcgttgc ttattatttt 1718281 gttcggtttc attacactcg gtgtgttccg gcctgaggct atgatgaaag agcggagaat 1718341 ccattttaag cataaaccaa gcgggttttt agggtcggtc ttaatcggaa tggcatttgc 1718401 agctggatgg acaccatgta ccggtccgat attagctgct gttatcacac ttgcaggcac 1718461 caatccgggc tcagcggtgc catacatgat gttatatgta ctcggttttg cggtaccgtt 1718521 tcttttattg tcttttttta tcacaaagct gaagtggata aggaagaacc agcttttcat 1718581 tatgaaagct ggtggcgttt tgatgattgt gattggtgtg ctgttattct ttaattggat 1718641 gagcctgatc attattttgc tgtcagatct ttttggaggc tttactggtt tttgacggta 1718701 aattactttc gtactactac taatcctttt gtttttggta caataagact attatctgtg 1718761 gaaatcgatt gttggagggg aatatgacaa gagttttagt tgtagacgac gccaagttca 1718821 tgagagtgaa aatcagagag atcttggaag aggcaaatta cataatcgca ggcgaagcgg 1718881 cggacggtga acaagcagct gacctgtata aaaaactgcg cccggacctt gtgacaatgg 1718941 atattacaat gccggtgaaa aacggcataa aagcgcttcg tgatatctta acctttgatc 1719001 ctaaagcgaa ggtcatcatg tgcaccgcca tgcgccagca aagaattgta acggaagcaa 1719061 ttgagctggg ggcaaaggat tttattgtta agccgtttga ggaaacaaaa gtgctggaag 1719121 ctgtaagccg cgttatggga cattaaagtc atttcttttc aaaatggttt tttttattgt 1719181 tttggagtat agtatatagt atcaacactc cgagaaacaa aggaatgata agtatgatga 1719241 ttatagtttc atcaattatt gctgtgttaa tggctgtagc tgtgatggtg gtcagaataa 1719301 agtcctctga caagcctgtt tcaccaaaaa aaatcattct tccgccgatt tttatgagta 1719361 cgggagcgtt aatgttttta tttccggtat tttgggtaac tggagcagag tttttggaag 1719421 cattcacttt aggtgtgatt ttctctattt ttctaatcaa aacttctaag ttcgaaatta 1719481 aaaataatga aatttacatg aaacgctcta aagcatttgt ttttatatta gtcggtcttt 1719541 tggtgatcag aatcgtgatg aaatcgatct tgagcacatc aattgattat ggtgcactga 1719601 gcggaatgtt ttggattctg gctttcggta tgattgtgcc ttggagaatc gccatgtatt 1719661 tatcatatcg aaaacttcat aacgagctgc agtcatctaa tattcaaatg aattaaaaaa 1719721 cctttcctct tgtcaggaaa ggttttttat ttgagaaggg tctgataagg ttccaaatcg 1719781 atttttttgt cccgcagatg cctttttaag aaggtatggt ctcttttagg agttgcgaga 1719841 atatagcctt tgatcataag ttgctgatca atctttgcta ccttttcttt taatgcaagc 1719901 tcaccgattt tgcctgcgat tttagctttt gctgcatctc tgaacagctc tggcacgggc 1719961 gcagtcaatt catctagaaa ctgtttgttt tcatcgttcc ataaatgtct gctgttttca 1720021 atatagtaat cctgccaatc aagctctgat ctgccgtcct cttttggtaa acgctttaaa 1720081 aactttcgaa acatgaaaaa accgccgatt gataataaga ctaccatcat gattacccaa 1720141 aacagaataa accataaaaa ccatccttcc agcatcaatc attccccctt attctaacca 1720201 tattgtatac gaagagagat tagaagaaca cagtaaaaaa agaatagaaa aaagtgatag 1720261 acgtctagtc aaaagagata gtagatcata ttctattgta tagtgaatct gctatttggc 1720321 catgggagag tcactagagg gtatttgacg ataaatggac ggaaaaaaag tcactttcat 1720381 aataggggat gaaagtgact ttttatgttt agctgagagg aaattgaaga gaaaaagaag 1720441 agccatcttc tgtttcttta ttgacggcga ctgtgagtat ttgattttcg cattcgactt 1720501 gaatgttttt gtcattaaaa taaaaaggaa gcatcatttg tttttcaaaa gtctgtcctg 1720561 acgatttgac agttaagatg aactcgcatc cagaaagggt aactgttact tgtgtaggct 1720621 gtaaaaaagt cagatccgct tctataatat actgctgact tgtttcatat aaatcaatag 1720681 gcaatgtttc gtcgtaccag gcgaaggggt cttcaaaaaa ttgccgaagc cattcatcca 1720741 tactatcgaa atcattcgca tcgttgcgtt ttgaatggtt catggaagca ttcctccaca 1720801 tatcaacctt gctttacatc atatgcggtg gattataaat gggtgaacgc ataaaaaaac 1720861 agacactaag gtctgctttt cttacatatc atggcttgag ttgtgctttt gtcttgtatg 1720921 gtttcggttt tttacttttt tgcttccgct tagaggctcg ggttggccgg gattgtgtcc 1720981 tttaggggcg tttttatgca tatctttact tgtattctta ttggtcataa aatgagaacc 1721041 tccttaaaag agttcggtgt tattgattgg tttttctttt tttgttattt tggcgttctg 1721101 cttcagtcag tacaagctgg tcgttttcaa tatagccggc gcctttgcct tggctttttg 1721161 cgtcattcat tccgttaatg acgtgattcg cttttctttt gaccatcatt atcacctcaa 1721221 tcataatatg gcttctttta ttgtgttata tgagagagcg taaacagtaa aaattaccgg 1721281 tacatttttc tcataagtcg aacttattgt atttaataaa aacattgata tttacttatg 1721341 tatgattttg ttttaatatg aaattgtgag aaaattgtga tggaatgtaa tgttcatctg 1721401 agaatgatct gatctgaagg gggattttgg agaatggcaa acgagcaaaa aactgcagca 1721461 aaagacgttt tccaagcgag aaaaacgttt actacaaatg ggaaaacata tcattactac 1721521 tctttaaaag cgttagaaga ttcaggtata ggaaaggttt cgaagcttcc ttattccatc 1721581 aaagttcttt tagaatcagt attgcgtcaa gttgacggct tcgttatcaa aaaagaacac 1721641 gtggaaaatt tggcaaaatg gggaactgcc gaattaaagg atatcgacgt tccgttcaaa 1721701 ccgtctcgtg ttattttaca agacttcaca ggggttccgg cagtagtaga tctggcttca 1721761 ctgcgtaaag caatggcagc tgtcggcgga gatcctgata aaatcaaccc tgaaattcct 1721821 gttgatctcg ttatcgatca ctctgtacag gtagataaag cgggtacaga agatgcatta 1721881 gcagtaaata tggacttgga attcgaaaga aatgcagagc gctacaaatt tttaagctgg 1721941 gcaaagaaag cgtttaacaa ttatcaggca gtaccgcctg caacaggtat tgtgcaccag 1722001 gtcaaccttg agttcttggc aagtgttgtc catgccattg aagaagacgg cgagcttgta 1722061 acgtatcctg atacgcttgt cggaacagac tcacacacaa caatgattaa cggtatcggt 1722121 gttctcggct ggggtgtcgg tggaattgaa gctgaagcgg gaatgcttgg acagccttct 1722181 tacttcccag ttccagaggt aatcggcgcg aaacttgtcg gcaagcttcc aaacggaaca 1722241 acagctactg acttggcgtt aaaagtaaca caagtgctgc gtgaaaaagg cgttgtcggt 1722301 aaatttgttg aattcttcgg accgggaatt gctgaactgc cgcttgcaga tcgcgcaaca 1722361 attgcgaata tggctccgga atacggtgct acatgcggat tcttcccagt agatgaagaa 1722421 gcgcttaact acctgcgcct gactggccgt gatcctgaac atattgatgt tgttgaagca 1722481 tactgcagaa gcaatggctt gttctacact ccagatgcgg aagaccctca atttactgat 1722541 gtggttgaaa ttgacctgtc tcaaattgaa gcaaacttat cgggtccaaa gcgtcctcag 1722601 gatttgatcc cgctatctgc tatgcaggaa acgtttaaaa agcaattagt cagccctgca 1722661 ggtaaccaag gattcggttt aaatgctgag gaagaaaata aagaaattaa gtttaaactc 1722721 cttaacggcg aagaaacagt tatgaaaacg ggtgcgatcg ccattgctgc gattacaagc 1722781 tgtacaaata catcaaaccc atacgtgctg atcggcgccg gactggtagc gaaaaaagcg 1722841 gttgagttag ggcttaaggt gcctaattac gtgaaaacgt cacttgcacc gggttctaaa 1722901 gttgttacag gatatcttgt gaattcaggc cttcttccat acatgaaaga gcttggcttt 1722961 aacctcgttg ggtacggctg tacaacatgt atcgggaact caggtccgct ttcaccggaa 1723021 atcgaagaag cggttgcgaa aaatgatctt ctgattacgt ctgtcctttc cggaaaccgt 1723081 aactttgaag gacgtattca cccgcttgtt aaaggcaact atcttgcttc accgccgctt 1723141 gttgtggcat atgcgctggc tggaacggta aacattaact taaaaaccga tccaatcggt 1723201 gtgggcaagg atggtcaaaa cgtatacttt aatgatattt ggccgtcaat ggacgaaatc 1723261 aatgcacttg ttaagcaaac tgttacgcca gagctattcc gcaaagagta tgaaacagta 1723321 tttgatgaca acaagcgctg gaacgaaatt gaaacaacag atgaagcttt atataaatgg 1723381 gataacgatt caacttacat ccaaaaccca ccattctttg aagagatgtc tgttgagcca 1723441 ggcaaggttg agccattaaa aggactgcgt gttgtcggta aattcggcga ttcagtcaca 1723501 actgaccata tttctcctgc gggggcaatc ggaaaagata cgcctgccgg aaagtatttg 1723561 caagaaaaag gtgtttcacc tcgtgacttt aactcctacg gctcccgccg tggaaaccat 1723621 gaagtcatga tgagaggaac atttgccaac attcgcatca aaaaccaaat cgcaccgggt 1723681 acagaaggcg gatttacgac gtactggccg actggtgaag taacatccat ctatgatgca 1723741 tgcatgaaat acaaagaaga taaaaccggt cttgtcgtat tagcaggaaa agactatggt 1723801 atgggatctt cacgtgactg ggctgcaaaa ggaacaaacc ttctcggcat cagaacggtc 1723861 attgcagaga gcttcgaaag aattcacaga agcaatcttg tattcatggg tgtgctgccg 1723921 cttcagttta aacaaggtga aaatgcggat acactcggct taacgggtaa agaagtcatc 1723981 gaggtagatg ttgatgaaac agttcgtcct cgtgaccttg tgactgtaag agcaatcaat 1724041 gaagacggca atgtaacaac ttttgaagca gtcgtccgct ttgatagtga agttgaaatt 1724101 gattactacc gccatggcgg catccttcaa atggtgcttc gtgaaaaaat gaagcagtcc 1724161 tgatgaatca ataggaagag aaggcatttc gctttctctt ctttttatga cacaatgtgc 1724221 tgcggaggtg gcatatgctg aaaaaatggc tcgcagggat cctgcttatc atgctagtcg 1724281 gttatacggg atggaattta tatcaaacat acagcaaaaa agaagtcgga attcaagagg 1724341 ggcaacaagc acctgatttt tctttgaaaa cgctatcagg agagaaaagc tctttacagg 1724401 atgcaaaagg caaaaaagtg ctgctcaatt tttgggcaac ttggtgtaag ccgtgccgtc 1724461 aggaaatgcc tgcgatggaa aagctgcaaa aagagtacgc cgacaaactt gcggttgttg 1724521 cggtaaattt cacttcagct gagaaaagtg agaaacaggt ccgagcgttt gctgatactt 1724581 atgacttaac gttccccatt ctgattgata aaaaagggat caatgctgac tataacgtga 1724641 tgtcatatcc aacgacatat atcttagatg aaaaaggtgt tatccaagac atacatgttg 1724701 gcaccatgac aaaaaaagaa atggaacaaa aactggatct tgattagatt cagttttttt 1724761 tatactcaaa tatgcttaca agttttcaga attggaaaaa ataaaagaat atgcggaggt 1724821 gagaagcgtg aagaagatga gaaaacgttc ttttcatgag ctcgtcatgg aaaacaaaaa 1724881 agagctgatg accaatacag agtatttaaa tcagcttgag gaaaagcttg aacagcgatt 1724941 taagcaaaaa taacctttaa tttgtattca tgtttacccc tccttttgag aaacctatct 1725001 gttgaggagg gataaacatg ggaaacaaca agaaaaacgg tcagcctcaa tatgctccaa 1725061 gccacttggg tacaaagcct gtaaaatata aagccaataa aggggaaaaa atgcatgata 1725121 cttcaggaca gcggccgatt atcatgcaga caaaaggcga gtagcgaaaa ttcgagttta 1725181 tttctaggag gtacatccga atgacaaaga accaaaatca atatcagcag cctaatcctg 1725241 atgatcgttc tgacaatgtg gaaaaattgc aggatatggt tcaaaataca attgaaaata 1725301 tagaagaagc agaagcatca atggagtttg cttcaggaga agataaacag cgtatcaaag 1725361 aaaaaaatgc aaggcgcgaa cagagcattg aagcgtttcg taatgaaata caggacgaat 1725421 ctgcagcgag acaaaacgga taccgttctt aaaaaaccag ggaaacctgg tttttttctt 1725481 tctgatttga ttatggtaaa atggggctaa attgacgtta agggagcaga gtaatcttgc 1725541 atgtatcaaa aaaagaaata gaagtgcgtt atgcagaaac agatcaaatg gggattgtct 1725601 atcacgcaaa ttatcttgtg tggatggagg tcggcagaac ggccttgatt aaggacttag 1725661 gctttttata tagtgatatg gaaaaaaaag gcgttctgtc cccagtcgtt gatatcaata 1725721 tttcctataa aaagccgctt cattacggag aaaccgcggt tgtacataca tggatagagg 1725781 actataacgg atttaaaacc gtctatggtt accacattta taatccggcc ggtgagcttt 1725841 ccatcaaagc cacctcatct catatttgtg tggataaaga aagctttaag ccaattcaat 1725901 tccgcaaagc ttttcctgat tggcacacag catatgaaaa ggccaaaaaa tagggaagtg 1725961 aacgggatat ggcgtttggt gtgaaacggg aggaacttaa ccggtggaaa caagcagtga 1726021 aaagaggaga aatcgcattt ttaacacatt actggctgga tgaccgattt ccagaagcaa 1726081 agaccgtgac aaaagccggc tgtgcagaca ttgataagct ggttcagtgg ggagcggcgt 1726141 acgggttaaa aaaagaatgg atccataaga aaagtgaatt tccccacttt gatctgctgg 1726201 gggaaacaca aaaatatatt ttggaacaag aaaacctaac cgatcatctt atacgatttc 1726261 atttgtaaaa aaagaacgca catgaagtgc gttctttttt attggtattc aaaaaccggt 1726321 tcatcagcgt cttctgaata gctgacgaga aggtcgtggt tatcaaagta ccataaatca 1726381 ctttcttcaa taaagaaggt aatgccatca gcttctgcag tgactccagc ctcttgtggg 1726441 gcatctttcg ctacaccgag agaaaaaccc ttttgaacgt tgctgcagcc tccatagcgg 1726501 acgaaaaagc gaacctggtc tccgctttcc aaatcgagtt cttctttata ccagttcaat 1726561 gcgtcttcgt taattgtcat attcataaca gaacacccct ttgttcttca tttgaatttt 1726621 ctctattata aacgtattag gctattctgt gtcaaaagag aagtttttta agcttataac 1726681 cattttactt taggttctgt tttattgata attcgtttaa tgttcgctcg gtgtctgtat 1726741 atcacaaaaa tagtgagcag ggtaacgaca atcaataaat acgtatcatg gacaaagaaa 1726801 ctatatataa cagtatagat ccctgttaac atcgatgaga gagaaacaaa tttagtcaag 1726861 tataaaaaga tgaagaatac cgcaaccatc gtgataaata acaggggtgc gtaaaatagc 1726921 aaaacgcctc ctgatgtcgc cacggcttta ccgcctttaa atttggcgaa gatgggaaac 1726981 acgtggccta aaaccgcaaa gactcctgca agaagcgggt gaatatcaac atgcatgaga 1727041 aaaggcaatg cagttgccag tgtccctttc aaaatatctc cggctatgac gaccgaacca 1727101 gcttttacac ccaatgtacg gaatgcattg gtagcgccta agttgccgct tccgtgctcc 1727161 cgaatatcaa ttcctttggc aagcttgccc acaattaagc cagatggaat gctgcctatc 1727221 aagtaggcca aaataatcaa taaagcaatt aacatctaca tttctccttt ttcaaattcc 1727281 cttcttttta ttttaacatg agatgtcatg atctgatgat aagttttttt gtaaagtttg 1727341 cttacaaatc aaatcaaaca tgcatcatat tttgatttct cctgttttga tcgtgtaaaa 1727401 taagtgaaaa aggagtgaca cacgatgcaa aacccttcta aagcggaaat taaagagatt 1727461 cttcaaagaa gcaaacgtat agcggtagta gggctttcag accgtccgga tagaacgtca 1727521 catatggttt caaaagcaat gcaggacgcg ggttatgaaa ttatccctgt gaaccctaca 1727581 attgatgagg cgctaggtgt caaagccgtt tcatctttaa aagagataga cggtccgatt 1727641 gacatcgtaa atgtattccg gcgctcagaa cagcttcctg gagtggcgga agagttttta 1727701 gagacagatg cgccagtatt ttgggcacag caagggctag ttaatgagga agcataccag 1727761 atgctaaaag aaaaaggcag aacggttatc atggatctgt gcataaaagt ggcacacgct 1727821 gtaacaaaat aggtgcagaa ctgcaaaaat ccttgtaaat tcaaggattt ttgcttttta 1727881 attttaagat attgtttgcg tattacggtg aaacagatac aataaagctt gaacagcttt 1727941 ttttgaatac cttgtccagc tgggtttcgg ccgttcgatt tgcgaaggtc tgctgcttta 1728001 tatataataa acaaacatac gttctcatag tgtaaaaaca gcactagccg atgttttgag 1728061 aagaactgat tcgttagctc tatgttgcga ttgcaaacat attggttata atgaggagtc 1728121 caaggcagta ctggctcgag gcgaggttta taaaaaatat cttatataca aatgatgtgt 1728181 aacactgaaa agagaaagac aatgttagtt tttgaaaggg gtttgtacgt ttggctagaa 1728241 aacagcaatt tgattacaac gaagatgcca tacaggtgct cgaaggcctt gaggctgtca 1728301 ggaaaaggcc gggtatgtat attggctcta ctgacgcgcg gggtttgcac cacttggttt 1728361 atgaaattgt agataactct gtcgacgagg tgcttgccgg ccatggagat cacataatcg 1728421 tcaaaataca taaagacaat agtatttctg tacaggatag aggccgcggc atgccgaccg 1728481 gaatgcataa gctcggcaaa ccaacccctg aagtgatttt aacggtgctt catgccggag 1728541 ggaaattcgg ccaaggcggc tataagacaa gcggcgggct ccacggagtt ggtgcatcag 1728601 tcgtgaatgc tttatctgaa tggctgacgg ttaccattga gcgggacggt tttgtctatc 1728661 agcagcgatt tgaaaatgga ggaaaaccgg ttacatctct cgaaaagatc ggcaaaacaa 1728721 aaaagacggg aactcttaca cactttaagc cagatccaac gatgttcagc acaaccactt 1728781 ataattttga aacgctctct gagcgcttaa gagagtctgc gtttttgtta aaaggactga 1728841 aaattgagct gattgatgaa cgcaatgacc agcgtgaggt cttttattat gaaaacggca 1728901 tagaagcgtt tgttgcttac ttaaatgaag aaaaagacgt cttgtctgaa gtggtctcgt 1728961 ttgagggtga gcatcattct atagaagtgg actttgcgtt ccagtttaac gatggttatt 1729021 ctgaaaatat tttgtcgttt gtcaacaatg tcagaacaaa agacggcggg acgcatgagt 1729081 caggtgcaaa aactgcgatg acgcgtgctt ttaatgaata tgcgcgaaaa gtggctttgc 1729141 tgaaagaaaa ggataagaac cttgaaggca ccgatataag ggaagggctt tcagccatta 1729201 tttctgtccg cattcctgag gagcttcttc aatttgaggg acaaacaaaa ggaaagctcg 1729261 gtaccagtga agcaagatca gcggtggatg cgattgtttc agagcagctt gcttactttt 1729321 tagaggaaaa tcgggacacc gcaacgcttc ttgtcaaaaa agcaatcaag gcgagccagg 1729381 cgcgcgaagc ggcacgcaaa gcccgtgaag aagcaagaag cggcaaaaaa cgaaaaaaat 1729441 cagaagcgac tttaagcgga aagctgacgc ctgcgggttc aagaaacccg gcaaaaaatg 1729501 aattgtatct cgttgaggga gattcagcag gcgggtcagc caagcaggga cgagaccgca 1729561 gattccaggc ggttctgcct ttacgcggta aagtcattaa tacagaaaaa gctaagcttg 1729621 ctgatatctt taaaaatgaa gagatcaata cgatcattca tgcgatcggc gggggagtcg 1729681 gggcagattt ctcaatcgat gacatcaact acgacaaaat catcattatg accgatgccg 1729741 atactgacgg cgcccatatt caagtgctgc ttcttacctt tttctatcgc tatatgaaac 1729801 cgctcattga gcatggcaag gtgttcattg cgctgccacc tttatataag gtcagtaaag 1729861 gaagcgggaa aaaggaaatc attgaatatg catggtctga tgaagagatg ggggatgtcc 1729921 tgaaaaaagt cggcaaaggc tataccattc aacgatataa gggtcttgga gagatgaacg 1729981 cagaccagct gtgggaaacg acgatgaatc cggagtcccg cacacttgtt agggtcaaaa 1730041 ttgacgatgc ggcacgtgta gagagacgtg tgacgacgtt aatgggagac aaagtagagc 1730101 cgcgcagaaa gtggattgag aaaaacgtcg ctttcggctt agatgaagaa agcaatattt 1730161 tagaaaatga aaacttatcg gtcgctgagg aggtttaatg attgtcacag ccagaattat 1730221 ttcatgattt accattagaa gaggtgatcg gcgaccgttt tggacgctac agtaaatata 1730281 ttattcaaga cagggcgctg cccgatgcga gagacggatt aaagccggta cagcgcagaa 1730341 ttctgtatgc aatgcataca gatggaaaca cgtttgataa aaacttcaga aaagcggcca 1730401 aaacggtcgg taacgtcatc ggtaactatc atccgcacgg tgacagctcg gtttatgaag 1730461 caatggtgcg gatgagccag gattggaaag ttcgtaatgt gttaatcgaa atgcatggaa 1730521 acaatggaag catcgacgga gatcccccgg cagccatgcg ttatacagag gcacgattat 1730581 ctccgatagc atctgagctt cttcgggata ttgacaaaaa cacggttgaa tttgtgccga 1730641 acttcgatga tacaagcaag gagcctgtcg tactcccggc gatgtttcct aacctattgg 1730701 tcaacggatc taccgggatt tcagcaggat acgcgaccga cattccccct catcatctgg 1730761 gagaagtcat tgatgctgtc attaagcgta ttcaaatgcc ttcttgctct gttgacgaac 1730821 tcatggaagt tattaaaggg cctgattttc cgacaggcgg tattattcag ggcgttgacg 1730881 ggataagaaa agcttacgaa accggaaaag gaaaaatcat tatccgcgga aaggctgaaa 1730941 ttgaaacaat cagaggcgga cgagaacaaa ttgtcattac tgaaattcca tttgaagtaa 1731001 ataaagcaaa ccttgtaaaa aaaatggacg agttccgtat tgataaaaag gttgaaggca 1731061 tctcagaggt tcgtgatgaa acggatcgaa cagggctgag agtggtcatt gaactgaaaa 1731121 aagaagctga tgccaaaggc attttgaatt tcttatataa aaatactgat ttgcagatca 1731181 catataactt caatatggtg gctatccata accgccgtcc gatgctgatg agcctgccgt 1731241 ctattttgga tgcatatatc ggacaccaaa aggaagttgt cacaaaccgg tccgtttacg 1731301 agcttcaaaa agcaaaagac agacatcata tcgtagaagg gctcatgaaa gctttgtcta 1731361 ttttggatga agtgattgca acaatccgtt cttctagcga taaacgtgac gctaaaaaca 1731421 atttgatcgc gaaatatgaa tttacagagc ctcaggctga agccatcgtg tcattgcagc 1731481 tatatcgttt aaccaatacc gatatcacag cgcttaagga agaggcagaa gagctcggta 1731541 aaaaaattga agagctcgaa tctattctga gcaatgataa aaaactgcta aaagtgatta 1731601 caaacagctt aaaagcactg aaaaagaaat atgcagatac gagacgctcc gtgattgaag 1731661 aaaaaattga agaaattaaa atcaatctcg aagtcatggt tgcatctgag gatgtatatg 1731721 taaccgttac gaaggatggt tacctaaaac ggacgagcca gcgctcattt gccgcttcca 1731781 acggtcagga cttcggaatg aaagatacgg acaggatgct gcatcagttt gaaatgaata 1731841 cgacagacgt gctgctgctc tttacgaaca aaggaagcta catctattgt cctgttcacc 1731901 agctgcctga tatcagatgg aaggacatgg gccagcattt ttcaaatcta atcactattg 1731961 accgtgatga aacgattgta aaggctatac cgataaaaga atttgatccg tcggcatatc 1732021 ttctattctt tacgaaaaac ggtatggtga aaaagacaga gctcactcat tataaagcac 1732081 agcgttattc taaggcactt gtagccttaa atctgaaggg tgaagatgaa ctgattgatg 1732141 tacatgtaac aaatggggaa agccagatct ttatggccac tcacttaggg tatggtctat 1732201 ggtttggaga agacgaagtg aatgtagttg gcgcgcgtgc ggcaggtgtc aaagggatta 1732261 acttaaaaga ggatgacttt gttgtctccg gtgagattct tcagcaatct gattcaattg 1732321 tcttgttcac acagcgggga gcggttaaac gcatgagtct ttctgagttc gagaagacat 1732381 cccgtgcaaa acgcggtgtc gtaatgctaa gggaactgaa aaagaatcct caccgtgttg 1732441 tagcactgtt cgcttgcggt cttgaacagc gactaatggc agaaacagaa aaaggcgaca 1732501 gaaaagaact gcagacaaaa gagttgcgga caaacgacag atacagcaat ggctctttct 1732561 tttttgatga agaggaatca ggcaaggtta cagctgtttg gcgccttcat acagaacaat 1732621 aataaaaaac ccgctcatac tatatgagcg ggtttcgttt gttttttatc agctttcatg 1732681 gttggtgaat agatctgtta cagcatgaat gacttcaatc ccctgccata caaataaatt 1732741 cagcgctgtg aaagaaaata agcctaaaat caccattctt aagataaaca acatgtttaa 1732801 cagcctcctc atattttcgt tacataatcg ggtgatgttg aacatgaagt ttgccgaaat 1732861 aagacgattg ataaaatttg gccagtataa agcttttttt ccgctgacgt ctgcgggagt 1732921 atcccgtact tttgctttca gcggtcagca gcagaacagc cattgcccat aaagcggtca 1732981 gcgtaaatgc ccctgtgatg gatttcttct catcatcagc attttggccg gctttcatct 1733041 catgcatttc ctgctggtcg gctacggctt tataatgatg gccgatatca aaggcgtggg 1733101 gaattgagaa caaatgaaaa ctggcaatcg ccaagaataa gatggatgct ttcaatatcg 1733161 ttactttttt caaatgatct ccccctcctt taatattact gaatattttt ataataatac 1733221 cccaatccat cctaaaagta aacctgattt attaaattta aaaataaatt taactttgtt 1733281 aagtatatat ctttttgctt atttttgaaa gagaaaactt cttttattag cgtatgtata 1733341 cccggtttat ggtgtgaata aaaacatatt ttaaatgata tgttgtttag gatttattac 1733401 tttatttatg tgtaaatcaa agagaaaggc aagagaatgg gaagaaatga ttacattgtt 1733461 aatagggtac tcttttttta aagccagttt gcaaggaatg tttttattcg taggaaaata 1733521 atagagaagg ggtcgacaga gtaacatctg gctatgacaa tattcttctc gaaaaaactt 1733581 cctaattcgt catattgtga tataataaaa ctcgttatgt taaaaaatct aacatcaaaa 1733641 tcgaattcgt attgaattga tgaaaacggg aggtaaatat ggagtctttt ttcaatagtt 1733701 tgattaatat tccaagtgat ttcatctgga aatacctatt ttatatttta atagggcttg 1733761 gattattttt taccatacgt tttggtttta tccaattccg ttattttatt gaaatgttca 1733821 gaatagtagg ggagaagccg gaaggaaata aaggtgtttc atctatgcag gcattcttta 1733881 tttcggccgc atcccgagtc ggcacaggga atttgactgg tgtagcctta gcaattgcga 1733941 caggcggacc aggcgctgta ttttggatgt gggtagtggc tgcagtaggc atggcttcaa 1734001 gctttgtcga aagtacatta gcacagcttt ataaggtaag agacggggag gatttccgcg 1734061 gagggccggc ctactatatt caaaagggtc ttggtgccag atggcttggc atcgtttttg 1734121 caatcttaat taccgtctca ttcggcttga tttttaacgc tgttcaaaca aatacaattg 1734181 ctggagcatt ggatggcgca ttccatgtaa ataaaatagt tgtagccata gttctggcgg 1734241 ttttaactgc gtttatcatt ttcggcggtt taaaacgtgt tgtcgctgtt tcacagctaa 1734301 ttgtgccggt tatggcaggc atttatattc ttatcgcttt atttgttgtc atcacgaata 1734361 ttacggcttt ccctggcgtt atcgctacaa ttgttaaaaa tgctttaggt tttgaacaag 1734421 tcgtcggcgg cggaataggc ggcatcatcg ttatcggtgc gcaacgcgga cttttttcaa 1734481 acgaagcagg aatggggagc gcaccaaacg cggctgcgac ggctcatgta tcccatccgg 1734541 caaagcaagg ctttattcaa acattaggcg tatttttcga tacatttatc atatgtacgt 1734601 ccacagcatt tattattttg ctgtacagtg taacgccaaa aggcgacggc atccaagtca 1734661 cacaggctgc tcttaaccat cacattggag gctgggcgcc gactttcatc gcagtcgcaa 1734721 tgttcttgtt tgcattcagt tcagttgtcg gcaactatta ttatggcgag acaaacattg 1734781 aatttattaa aacaagcaaa acatggctga acatttaccg tatcgctgtt attgctatgg 1734841 ttgtgtatgg atctttatca ggcttccaaa tcgtttggga tatggcggac ctctttatgg 1734901 gtatcatggc gctgatcaac ttaattgtga ttgcgctgct gtcaaacgtt gcttacaaag 1734961 tgtataaaga ttacgcgaaa cagcgtaagc aaggacttga tcctgtgttt aaagcgaaaa 1735021 acatcccagg gctgaaaaac gctgaaacat gggaagatga gaaacaagaa gcataatata 1735081 aatataaaac aaagctgcat tcaatagttg aatgcagctt tttcattatt ggaaataaat 1735141 ttaatttttc gactcgaatg aaaaatgacg tgtaaagtcc caattcagtc cagttttctt 1735201 tgttctatat gtgtcatgtg tgtcttattc attggaggta gagcaaattg acaggctttt 1735261 aaacctcccc aaaacaagaa attaggttga tagacaatca tgagaaagat ttttacaatg 1735321 agttcgtgct cataagaagt gtagagccaa aatgatgcga aggaggaaaa gatcagatat 1735381 gaaacggtca atctctattt ttattacgtg tttattgatt acgttattga caatgggcgg 1735441 catgatagct tcgccggcat cagcagcagg gacaaaaacg ccagtagcca agaatggcca 1735501 gcttagcata aaaggtacac agctcgttaa ccgagacggt aaagcggtac agctgaaggg 1735561 gatcagttca cacggattgc aatggtatgg agaatatgtc aataaagaca gcttaaaatg 1735621 gctgagagat gattggggta tcaccgtttt ccgtgcagcg atgtatacgg cagatggcgg 1735681 ttatattgac aacccgtccg tgaaaaataa agtaaaagaa gcggttgaag cggcaaaaga 1735741 gcttgggata tatgtcatca ttgactggca tatcttaaat gacggtaatc caaaccaaaa 1735801 taaagagaag gcaaaagaat tcttcaagga aatgtcaagc ctttacggaa acacgccaaa 1735861 cgtcatttat gaaattgcaa acgaaccaaa cggtgatgtg aactggaagc gtgatattaa 1735921 accatatgcg gaagaagtga tttcagttat ccgcaaaaat gatccagaca acatcatcat 1735981 tgtcggaacc ggtacatgga gccaggatgt gaatgatgct gccgatgacc agctaaaaga 1736041 tgcaaacgtt atgtacgcac ttcattttta tgccggcaca cacggccaat ttttacggga 1736101 taaagcaaac tatgcactca gcaaaggagc acctattttt gtgacagagt ggggaacaag 1736161 cgacgcgtct ggcaatggcg gtgtattcct tgatcaatcg agggaatggc tgaaatatct 1736221 cgacagcaag accattagct gggtgaactg gaatctttct gataagcagg aatcatcctc 1736281 agctttaaag ccgggggcat ctaaaacagg cggctggcgg ttgtcagatt tatctgcttc 1736341 aggaacattc gttagagaaa acattctcgg caccaaagat tcgacgaagg acattcctga 1736401 aacgccatca aaagataaac ccacacagga aaatggtatt tctgtacagt acagagcagg 1736461 ggatgggagt atgaacagca accaaatccg tccgcagctt caaataaaaa ataacggcaa 1736521 taccacggtt gatttaaaag atgtcactgc ccgttactgg tataaagcga aaaacaaagg 1736581 ccaaaacttt gactgtgact acgcgcagat tggatgcggc aatgtgacac acaagtttgt 1736641 gacgttgcat aaaccaaagc aaggtgcaga tacctatctg gaacttggat ttaaaaacgg 1736701 aacgttggca ccgggagcaa gcacagggaa tattcagctc cgtcttcaca atgatgactg 1736761 gagcaattat gcacaaagcg gcgattattc ctttttcaaa tcaaatacgt ttaaaacaac 1736821 gaaaaaaatc acattatatg atcaaggaaa actgatttgg ggaacagaac caaattagtt 1736881 aagctttttt ttggcggaca tcagtaacga tgtccgtttt tatcatctaa taggaggttt 1736941 gcgttgtgga tgaaatactg aaacagtata tggtgctgta taaaaaaatg agtaatatga 1737001 taaatggtcc cgactatcca ggtaaggaaa aagacatcca gcatcaaaaa gatcagatcg 1737061 aagtttacga aaaacagctg cagcaaggat tttctacaga ttatgactat gatgtgtttg 1737121 ctgattctgt tatcaaatgc gcatatggcg atatgacgct ggaagattta gaagccgttt 1737181 attatggatt gacaacacca tttttttgat ttgtcattca gcagtaaaat ttcaatttct 1737241 gtctcactaa cttaagtata ctttgatatt gagacagaaa tttatttatt ttgtttactt 1737301 cctagaatat atattatgta aactagaaaa gatgaagaat aaagctttgc tgtttttatg 1737361 tacatccttt cttcttcctg taattcagca acaaaataaa aaagcgattt cccaatcgga 1737421 aaatcgccaa ttcagacact ctattattta tgtgtgtctt tgtgctctta acgatttaca 1737481 acaaatgttg tcacgctttg agctggaaga tgagcccaaa aatgattgcc tgatacagtg 1737541 agattcgttc caggttgtag attgctgctg ctgctcgtga tccatctaga tacgtttgaa 1737601 gcagatccat tctgcaaaac aaagttttgg ttgactcctg tgttgctttt attgatggca 1737661 acaataacga ccttgttgtc acctttatag gctgacacgt aaacgttcgc attagggttt 1737721 ttcgttgcat caatccttac atagccggga cgcacaaact ttgagaaatg agccatattg 1737781 tagccgcgtt tgctgatcgt accatcttct ttcataggtc catatgatct tcggatgtac 1737841 caccatacat aagcttgaaa gtccccctct accatcgcat tgtgaatatg ctgtgaaaca 1737901 tccaatgcct caggccatcg atccgccgag ttggtatcac tgtttggata gtatacttcc 1737961 gtcatccaaa ggtccttccc cgctcctttt tgtttgaaaa gaggataagg gaattggctg 1738021 acctgggtgc cgtacaggtg agttccgaga atatccatat tggcaagagc ctgcggatcg 1738081 ttcaagatcg ggtccgacaa attcttcaag tattgaaatg actcaggcgc aatgacgcgg 1738141 gcattgatcg agccggcgtt ttctctcata aagcgaagta tttcttgcgg cgtccaccac 1738201 gtccactcgt gagcgtaatc aggctcgttt tggaccgaaa tcgcgtaaag attcacacca 1738261 ttattcttca tgaaggtaac aaaatcgtta agatgctgcg cgtatgctgc gtacttgttg 1738321 tatttcagcc gtttagccga tgtgtcacca ttccgattaa aggtctcaac catatcactt 1738381 ggaggattcc aaggagaagc aaaaacgatt gctccgtgtt tgaccgcact ctttgcagtc 1738441 tccacctctt tataccaatt atttcgattt tcatctacat gaattcttaa gattgaaaat 1738501 cctaactggt tctgtccatt gccaaaagca gtttctcttt gagctgctgt aagatcccca 1738561 gcccaagccg gatgattcat ccctccaaaa ccgcgaatca cttgtttctc tgcagataca 1738621 ttaactgtta catcacttgc tgccaaaact tcagtagcgc ctggccctaa catgactgac 1738681 agcatagtga aacatactaa tagtacacaa attgtttttt ttatgcgtgg aatcatttat 1738741 tcctctcctt cgtcatgtgt cttttacggt attaaaaaat ctgcatggca tatccataat 1738801 ggcgggctgt tccggtgctg gcccgtactt cacccgcctc gtttttaagc ggtcccatta 1738861 cgagtactat ctttgcgtaa actgccagta atcaaaatta aacaagtttc ctgtacctgt 1738921 tccggtaaat acaaagaata ctttgtgcac accggttgcc ccgcttaccg cagtttctat 1738981 ttccctccac gtttgcgctc cgcctgttga aggcacattc agagttccaa caagcttacc 1739041 gtctgcactg tcgaggcgca cttctatttt cccgcctaaa gtggatgcta catttgcttt 1739101 aaatgacctg gcaccgcccg ctccgaagtc tgcatttcct acagcaatcc agtctccatt 1739161 ttgaatgctt gttacatgct gattatttac tggcccgccg ggtgctgtgg acttctctgt 1739221 caaaatgcgt ccattccaag caaacgtttc agcttctacc cggttatatg ggtttaaatt 1739281 ggaaatttgt gttacacctg cataatttgc cgctacctct tgaatagatc catctgcatt 1739341 atgcaccagc ttattaatat ggggagagcg gtatcctttg ccggccccga acagagcgga 1739401 actgacagtt tgcgcatggt acaccacata ccactcgttt ttaaaattga aaacagcatg 1739461 atggttgttt ccgccacctc cgaaaaatgc acccggattt ttcaggaagt gccctctata 1739521 tgtaaaggga cccatgggac ttgaactggt catgtagccg atctcacccg ggggtttatc 1739581 ggccgggtgc gtgccgccga aattgatgca ataggagtaa taatatgttc cgttatactt 1739641 gtgcaatccc gaatcttcaa acatgaaagg cgcatcaatt gtagatgcac ttccaacaac 1739701 actcgtcata tcaggcccca attttatgac tctagccgtt ttaggattgg cccattgtcc 1739761 ctgcgttgga tttgaaacgc caggaacgcc tccgccggca tacaggtaac cggttccgtc 1739821 gtcatctaca aatactgccg gatcaaaaag ccatacaaca ccagacattc ctggcgtact 1739881 tggcgttacg agcggttttc cgattgggtc ggtccatgga ccaatcgggc tgtctgcggt 1739941 gagaaccccg atacctccgc cgctgtttgc gaaataaagg aagaatttat ccttgccatt 1740001 aattttttta actgcgattg acggtgccca tgacgcacct gcccattttg caattccacg 1740061 gcctccatta gctccattgg cacctgctac cggaatggct ccgtggtctg tccagttcac 1740121 catatccgct gaagatatga cgaatactct attcaaattg gcaaatgaat tatctttaat 1740181 tgttccgttg ctattatatt catagtcatc acttgacata tagatgtaga ctcttccgtt 1740241 ataggtcagc gcaaccggat ccgctcccaa atgatggtcg ataagcggat ttgaattccc 1740301 tatatgtttt gcaattgtag tactagtggc agcatacgca gacttcccag ataagcagct 1740361 caataataaa actagaatcc ataaacatac gctacacttt ttcctcatca cttcacatcc 1740421 tcctttttcc ttaaaatggg ggattttctt ttggaatttg ataacaacag gtcacgaaga 1740481 ttgcacgcat aaagtagccg gaagctgttt agcaatgttc ccagttgttc tgaaagctca 1740541 tcttcatgtg tctccattct ctcttttctt cgaggagatc gcaccactcc ttcaaaattg 1740601 ttcaaaaaaa cttccccatt cctagcgacc attgtccaga aaataaaaag acaggattgt 1740661 tcatggcctc ccactaatca cattgaacgg agattacatc attatccaag atatcccttt 1740721 atctaacatc ctacatcatt aaaaaaattg tgtatagaaa cttttggagg agttagtgtt 1740781 cgattctaca aaggaactgg atacatttat tcattgataa gatggggcta acactccgtt 1740841 tatatttgta tgttttcaga cacaaaaaac agccgttcaa tgcggctgtt tttttcaaga 1740901 gtataagact attgagcggt atacccgctt tttcatgttt tgttcatatt ttattaattg 1740961 tttattcaac actgtccgct atagtaatcc atatcaacaa atatgactgc cactcgcatc 1741021 ttttatgaag ggaggttcgt tacgctgaaa gaaaaaataa agacattagg ccgtttttgc 1741081 accgtaggcg tcggcaatac gctgatagat tttggtgtct tctttcttct taccgcttgt 1741141 catgtctctt atctgccggc gcagatctgc tcctatactg caggtatcgt caacagctat 1741201 gtgtggaacc ggaattggac gttttgtgtg aaacgtaagg ctgacgggaa agagatcgtg 1741261 cgttttctca tgattaatat tgccgcgtca gggatcacct ttttgctgct ttatttgttt 1741321 caaaattgcg gctgctcgct tttggtgagt aagctcgccg ccactatcgg cggaatgatg 1741381 atgaatttta tcggaaaccg aatctgggta tttggagatt cgctgaaaaa catacaggat 1741441 caggagtgaa gatgaatgag aaaaaaagtg agaaaagcgg ttatacccgc agcgggttta 1741501 ggaacgagat ttctgccggc gacaaaggcg cagcctaaag aaatgcttcc aatcgtcgac 1741561 aaaccagcaa tccaatatat tgtagaagag gccgcagagt caggaattga agatatactg 1741621 attattacag ggagaaacaa acgctcgatt gaagatcatt ttgatcggtc ggcggaattg 1741681 gaattcaatc tccgggaaaa aggcaagacg gagacactta aggaaatgca gcagattgcc 1741741 gatttggcca acattcatta catccgccag aaagaaccgc tcggattagg ccatgcggtg 1741801 ctgtgtgcgg agcattttat cggagatgag ccttttgctg ttctcttagg tgatgatatt 1741861 atggtgtctg aaacaccggc tcttcggcaa ttaatggatg tatatgacgt ttatggcaca 1741921 gaggttgtcg gtgtacagtc agttctccct gaggatgtca gcaaatatgg tattataaat 1741981 acatcagggt ctcaagggca tgtatatgaa gtgaacgatt tagtggaaaa gccttctcct 1742041 gaagaagcac cttcggaaat cgcagtaatg ggacgttatg tgctgaattc ttcgatcttc 1742101 tccgttttga agacaattgg cagaggcgcg ggcaacgaaa ttcagctgac agatgcgctt 1742161 cgtgaggttt gccgtaagga gccgatccat gcccggctgc tggaaggaaa tcgatatgac 1742221 attggcgata agctgggctg ttttaaagcg agcaccgaaa tcggcttaat gcgtcccgaa 1742281 atgagatctc agcttttggc ctatttagaa gatgtgatca aacgggaaac gaaagaaatg 1742341 ctgcggtaaa aaaattgtaa ccatcttgct cgtcaatcag tcatataata gtgaaaaaga 1742401 ttaggacagg ttgtgaagaa tgtgggcagt ttgataagcg aaattttaac atggctgacg 1742461 aacatgggat atgcgggtat tgcgattggg ttaatgattg aaatcattcc gagtgagatt 1742521 gtattagctt atggcggcta tatggtatcg gagggcacga ttggatttat tggcgcaatt 1742581 attgcgggtg ttatcggggg caccattgcc cagatcttta tttactggat cggtcgctat 1742641 ggcggcaggc catttctgga caaatacggg aagtatttat tgattaaaaa gcatcatatc 1742701 gatatgtcgg aaaactggtt tcagaaatac ggcgccggag ttgtcttctc ggctcgtttt 1742761 ataccggttg tcagacatgc catatccatt ccggcaggta ttgccagaat gccttttctc 1742821 aaatttgtgg tactgactgt gcttgctatc attccatggt ctatcctgtt tgtttattta 1742881 ggcatacagc taggaagcca gtgggatgat gttgagaata tagcaggcac ttatacaaca 1742941 ccgattatga tattggctgt tgtcgtgata gccctttatt ttgtgattaa gaaacgtaca 1743001 gccatattta aacgatagct agcggatatg cataggggtg actgacgctc ccctatgcat 1743061 atttttttac ttgcgatgtt gatttgccag cttcagattc tccgctaaaa atgcgacaaa 1743121 cacttcatcc cgcacgagcg atgcggcata atttctctta ataaaccatt ctgcctcttc 1743181 aaacgctgcg aatgtttcgt cttgggtttc tccgttaatt tgaatattcc attcgttgtc 1743241 taaagggaaa agaaaaaatc tcatttgtgc gcgattttca tataatgatc cattcgcaga 1743301 tccctttaga ttatagatgt tacggaaggc atccggccgt acaggatcaa tacggaaagc 1743361 ttcagctaca aacaactcgt atacttcatc ggttattgaa cagccggacg cttttgcatg 1743421 ccctccgccg ccatatcggc cggcgatttc tgacacatcg atgtaatcat gaatggtgcg 1743481 gagactgact cgttttgacc ccatgctcaa aatcgcaatg taatcgaggt gcgggttatc 1743541 tttccctagc ctgttcccca gctctgaatg gtacgattca gcgtgaacga tgcctacaca 1743601 gtgttcgtga acaaaggttt gtaccatttc ccttttcttt ctgcggaggt agcgctcgat 1743661 tttttcgtct tctaaatcaa gcagtttttc ttcaaaatca tcgaagaaaa attcgtcatg 1743721 cgtggaaagg cgctggatca tttttgcttc aaattcatcg attgacagca aaaagaaaag 1743781 atcattaagc cgcttcgcct gtttttgatc gtaccgctcc cactcccatg tatcgtattg 1743841 gcggacgagc tctgtgaatt gatctaaggc gtttgtcggt ttcatgaagc cattttcaat 1743901 gagatagcca tataaaagcg atgtcgcgga tgtgagcctt ccatcatcgt attccacctg 1743961 gacaaatccc cattcatgct cattcaaatg aagggctgtt ttatgatggt caatgagctt 1744021 cactttgccc cctgcatgaa catactcatt caatctctct tcgttttctt cattgacggc 1744081 gagatcggtg atgaataacg cgtcctgtct gttgctctcc ttcgcttttt ctaaaaagta 1744141 ctgcacctgt gcgtttaagc cgttgacaga gttataccgg atctctacgt cttttccgaa 1744201 cgccaatttt gctacgattc cgcatcctac tccgtccaag tcgttatgtg aatataaatg 1744261 atacataatg taggcccctt tttatgataa actgacaatt gccgctagag gtgcggcagc 1744321 ctttatttac tattctaaaa aaccaagcgt tttatgcaat ggtaattagt tgacataatg 1744381 ttgttattgt aaatatataa aggagcgctt tttttgcgct cctaagttct tgcttttaca 1744441 ccggataaac cggatgcttt cgattggtaa atgtcatttc ctttgtcatg tatgccttga 1744501 gccgtttggc cagctcatca cgcagcgaat tggctgggat aacagcatca atgatcattt 1744561 ctgaagccag acggtagata ttgatgtcct ctttgtattc ctcccgtttg ctgctgataa 1744621 atgcggctct ctcttcttct ggcagctcgg cgattttttt agcgtagaca gcgtttacag 1744681 cggcctcagg gcccatgacg gcgatttggg cggttgggag cgctagacag caatccggtt 1744741 caaatgccgg ccctgccatt gcatacaacc ccgccccgta agcttttcgg acaatgacag 1744801 agagttttgg aacagttgcc tccgacatcg cagaaatcat tttcgctccg tgtctgataa 1744861 tcccagcctg ttctactttt gtgccaatca taaaaccggg gatatcggct aagaacagca 1744921 atgggatatg aaaagcgtca cataaggtaa taaacttagc cgctttgtct gctgaatcgt 1744981 ggaataagac gcctcctttt accttcggct ggtttgcaac aatgccgaca ggctgtccgt 1745041 ggattcgtgc gaggcccgtc aataattccg gtgcaaataa ggctttgatc tcaaaaaatg 1745101 agtcttcatc tatgacccgc tcaatgagct catgcatatc aaaaggtgcg ttttgatttt 1745161 gcggaatgac gtcggcaagc ggagtttcga agtgttttgg cgggcgtttc tcatgaatgg 1745221 gcgctttttc ttgaaaattt gccggaaagt aagacaaata agcccgcacc agctgtatgg 1745281 cttcttcttc agtttctgca agaatatctc cgcagccgga gattgagcaa tgcatacggg 1745341 cgccacccat ttcttcgaga gacacttttt ctccaataac catttccgcc atccttggcg 1745401 aacctaaata catggaggcg ttaccgtcta ccataacgac gatatcacag aaggccggaa 1745461 tataagcgcc tcctgccgca gatggtccga aaagcagaca gatttgcgga atgcgtcccg 1745521 ataatttgac ttgattgtaa aaaattcttc ctgcaccgcg tctccctgga aagacattga 1745581 tttggtcggt aattcgggcg cctgccgaat cgactaaata aatgagcgga cagtttaatt 1745641 tttcggcgat ttcttgaatt ctgatgattt tttcaactgt ttttgctccc catgaccccg 1745701 ctttcactgt tgaatcattc gccatgacgc aaacggtttg gccgccgatt ttgccgatag 1745761 cggttacaac tccgtcagcg ggaagcccgt ctgacataca ttccgcaaaa aaagcgtctt 1745821 ctagctcaat gtcatcgtca aagagaaggg aaagccgctc tctgacaaag agcttgcctt 1745881 tttcccgatt gctttgatga tacttttccg ctccgccttt tcgaatccgt tcagcccgtt 1745941 ctgttcgttc cttttcataa tccatcagca ttgcctccct tttatattcc cttgtatacg 1746001 gcccgtcttt tttcttgaaa ggcctgaagc ccttctctcc tgtcttttgt cgggatggtt 1746061 tgttcatacg ctttttgttc aatcgcaagg cctgtagcaa gatctgtctc caatccttta 1746121 ttgattgcaa atttagcctg acggacagcg atcggtccgt tggcagaaat ggctgcggcc 1746181 agttcctctg cttttggcat aaggtcacaa ggagccgtga catgctctac aaggccgatt 1746241 tcttttgctt cgtgtgcggt cacgcgtctg cctgtataaa tgaattcttt tgcttttcct 1746301 ctgccaatca gccggggcag cctttgggtc cctccagcgc ccgggataat agctaaccct 1746361 gtttccggaa gtcccagcac agctgcttca gttgcgattc gaaggtcgca tgccaatgcc 1746421 aattctagtc cgccgcctaa tgcgcttcca tttatcgcag ctatgaccgg ctgcggcaag 1746481 gcatcaagta aagccgccgt tctttgaatg agagatacac tttccagaac ctgatcttct 1746541 ttcagtttta tccgttcctt caggtctgcc cctgcacaaa acgctttttc accggtgcct 1746601 gtgaggatga cgcaacggat gtttgagtta aattcaattt cctggataat catttgcagg 1746661 tttctaagca tttccgctga aagagcattt gctgcctgag gcctgtttaa ggtgatcaac 1746721 gccatatgtt catttttaac agtaaaaaga atagaatctc ccattgtatg cgtcctccct 1746781 tttatcaaga tgatttaaac acctgtaaat ttctgctcgg cagcggtttg cccatttttt 1746841 cttcaatcca tttggccgca gatagcagtt tttctagctt tacatttgtt ttgatatcca 1746901 tctgttcaag catgtacacg atatcctcag ttgcggcgtt tcctgatgaa cctggcgcat 1746961 atgggcatcc cccaagcccg cctgccgagc cgtcgaacac cgtgatgccc atttggagtg 1747021 ctgtgaccat gttggccaga gcggttcctc tcgtatcatg aaaatgcagg gcaatttgat 1747081 tagccgggaa tcgtgccaaa agagcttcaa gtacagtttc cacttgggcg ggattagctg 1747141 ctccaatcgt atctccaagc gacagttcag aaatcccaaa ttcaaataga gcttctgaaa 1747201 ggcgaatgac ttgttcaatg gggacatctt tttcgtacgg acagccgaaa acagtcgaga 1747261 ggtaggctct tgttgtgagg tttgcttttt gtgcgtcgtt gtttacttgt ttgagtatat 1747321 ggagggattc agaagtggat ttattgatgt tttttctgtt gtgcgtctcg ctggcggaca 1747381 taaaaacgca agcctcgtta atgcctcctt caagtgcatt ctccagtcct ctttgattcg 1747441 ggacaagtgc cgcgtacgtt accccttttt ctcggtcgat gccttttgct acatcgatag 1747501 catctcgaag cgccggaatc catttcgggt gaacgaagga tgtgatttca atatacgaca 1747561 gccctgtccg ggaaagctgg ttgatccagg ttattttatc ctctgttgcg atccaaacgg 1747621 gctcgttttg taagccatca cgcgggccga cttctttgat tgtcactttt ttaggatatg 1747681 gcatggtctt cctccaaatt attgagtgga attgctcagt tcgagcagta cgtctccttc 1747741 atttacaaag tcgccttcct tttttttgac ttcttttacg attccgcttc tatctgcaac 1747801 gatcgggatt tccattttca tcgattccaa aatggctacc tcctggccct tttcgatttg 1747861 gtcgccggct ttgacgtgga ctttccacag gtttcctgcc atttgtatgc taaccgtcat 1747921 gacaactgcc tcctttatag gtgctgtttc aaaaagtcag tcgtgacatc cccttcttta 1747981 aatgcctttg ttgccgcagc ctgtatgagg agcggaaggt ttgttttgat tccctctaca 1748041 cgatagtcgc gaagcgctgt ctctagtttt tcaattgctt ctgttctggt ttggcctttg 1748101 acaatcatct tagcgatcat cgggtcataa aaaggggtaa cggtgctgtc ttttgctacc 1748161 gcacattcgt gtctgactcc tttttggtca ggaagtgaaa acgcagtgat cgtacctggt 1748221 gacgggaaga aggtcttggg atcttccgcg tatattcgaa cctctatcgc atgcccgttc 1748281 cgttggatgt ctttttggga gaatgtgagt gtatggcccg cagcaatccg cagctgctgc 1748341 tcaactaagt ccaggcctgt tatttcttca gtcacggggt gttcaacttg cagtctcgta 1748401 ttcatttcga ggaaataaaa attttgtttc tggtcaacta taaattcgat ggtgcctgcg 1748461 ttcgtatagc cgattgcctt cgctgctttt accgctgttt gaccgatctt cattcttagt 1748521 tcatcgtcta caaatggaga cggtgcttct tcaatgactt tttggtggcg cctctgaaca 1748581 gagcaatcac gttcaaacag atgtactgta tggccgtgtt gatcggccaa aagctgaacc 1748641 tcgatgtggc gcgcatgttc aataactttt tctatataca tagacccgtc accgaaaaaa 1748701 tctgctgcgc gctttttgtt tccctcgtac gcttttttta atgcttcttc attttcaaca 1748761 cgctgcattc cgatgccgcc tccgcccgct gaagctttca gcatgacagg atagccgatt 1748821 tgacttgcgg tgcggcaggc tgcctctata tctccgaggg attcagaaac gcccggcacc 1748881 acagggacac ctgcagcctc cattgctttt cgcgcttcaa ttttgctgcc catctttgcg 1748941 atgatatcag gggaaggtcc gataaacacg atgttttctt gcttgcagcg ttcagcgaac 1749001 cggctgtttt ctgataacaa tccatatccc gggtggatcg cgtcggcttt tgcttttttc 1749061 gccgtcttta tgattctctc tatatttaaa taactttcac tgactctcga ttccccgatc 1749121 aaatatgcct ctgtagcggc ttttgtatgg ggcgcgtcct tgtctgcttc tgaataaaca 1749181 gcgaccgttt taatgccgag acggctgcat gttcggataa ttctcattgc aatttcaccg 1749241 cggttggcga tcagtacttt tgtaaacatg atttcacctc attgacttga tgataagttg 1749301 aacatttcaa tcgttttttc tcgcagttta tatttttgaa ttttgcctga ggccgtcatc 1749361 ggatagtcat ccgtaaaaat aacataacgc ggaattttgt ggcgggcgat tttccctttg 1749421 caataggctt taagctcatc aggtgaaacg cttttaccgt ctttcagttt aatccaggct 1749481 gcagcttcct ccccgaattt ggcgtcaggc acaccaacca cctgtacatc taaaacagcg 1749541 ggatgctggt ataaaaattc ttcaatttcc cgcggataaa tgttctcgcc gcctctgatg 1749601 agcatatctt ttaatcttcc ggtgatgcgg cagtacccgt cttcatccat gacagcaaga 1749661 tctccggtaa acagccatcc gtcatgattg attgcttttc tggtcgcatc tttgtcttta 1749721 taatagcctt tcatgacgtg atagccacgg gtgcacagtt ctccctgcat gcctctttga 1749781 acttcttgac atgtcccggg ttctacaatt ttcacctcag tatgtggcag ggcacggccg 1749841 gttgtttcga ctcttcttat gaaggaatca tttgctctcg tttgtgtaat gactggcgag 1749901 gcttcggttt gtccataggc gatcgtaatg tctttcatgc ccatcctttc aatcacagct 1749961 ttcatcactt cacttggaca gggagagccg gccatgattc ctgttcggag cgtcgataga 1750021 tcatatgcat caaaatccgg atgatgcagc tcggcgataa acatggtagg cacaccatgg 1750081 agcactgtgc atttctcttt ttctaccgtt ttaaggacgg taacgggatc aaattcttgc 1750141 acgggtatca tggctgcccc gacggataca catgccaaaa ccccaaggac gcatccaaag 1750201 cagtgaaaaa acggaacagg gatgcacatg cggtcttgag aggttaaagc catacattca 1750261 gcgatattag cagcgttatt gatgacattg aaatgggtca gcatcacgcc ttttggaaac 1750321 cctgtcgttc ctgatgtgta ttgcatatta atcacattgt ctttatccag gctgttcatt 1750381 ctctcttcaa gctcagcatc tgtcactgtt ttcgccaata tctctgtatc gtcccaatga 1750441 tacatgccag acaatcgttt attgccaata tagatcagcg tttttaaaaa gggatagcgt 1750501 tcagatttca gttggccggg ctttgcttct tgcagttctg gaattaaact gttcacgatg 1750561 tctggataag aagtgcccct gtatgaatcc atgataataa gcgccgcggc atccgattgc 1750621 tttaacaagt aatcaagctc atgtgcttga taattggtat tgacggtcac gagcacggct 1750681 ccgatcttcg cagttgcgaa ctggacggca agccattcag agatattaga agcccatatg 1750741 gcgacgtggt ctccttttcc aatccccatc cgcatgagac ctttagcggt ttgacggcac 1750801 agactgtcaa attgagcgta cgtatagcgg atatttcggt ctggatacac aacagcatct 1750861 cgatcgggat acgcatcagc tgtttgttcc agcagcctgc cgattgtgga atggatgagt 1750921 tcagccattc attgttcctc ctttcttaat gataggaaag cgtttacatt tttattttaa 1750981 aagctgtctg gcgatcacga gacgctgaat ttcagatgtg ccttcaccga tttccattaa 1751041 ttttgcgtcc cgcagcatcc gttccacccc atactctttc atatagcctg aacctccatg 1751101 gatttgaatg gcttgattgc aagctcttgt cgccatttca gatgcgaata gcttggcgta 1751161 cgccgcttct ttggtgaacg ggcggttatg atctttcagc caggcggctt ttaacaccat 1751221 ttgccgtgcc agatcaattt ccatcgccat gtcagcaagc ttaaattgaa tcgcttgaaa 1751281 ggaagaaatc ggctgtccaa actgctttcg ctctttcgca tatgccaatg atgcgtcaag 1751341 ggccgcttgg gcaatgccga ctgcaagagc agcgatggag attcgaccac catccagcgt 1751401 atatagaaac tgtttaaacc cttttgttgg atcgccaagt aagttggccg caggcactct 1751461 tacatcttca agcaagattt ccgctgtatt cgaaccgcgg acgcccattt tatcgtacgg 1751521 gctcgtaatc gtaagtcctg gtgtgtcagt tggcacgatt aatgcggaga tgatgttttt 1751581 tccgtctttg tttttgcctg ttacggcggt tacaataact gtgcgtgcgt agcttgcatt 1751641 agtgatccag cacttttcgc cgttgattac atactcgtca ccatttgaaa tcgcttttgt 1751701 ttgagtgcct cctgcatctg agccggcatt tggctccgtc aggccgaatg atccgagtgc 1751761 tgtgcctgaa gccagcggcg tcaaatgcgt ctgtttttgc tcttctgttc cgaagtagta 1751821 aagagggctt gcgcctagcg agaccgctgc agcatagctt aatccagtac tgccgcaggc 1751881 tttgccgact tcttcaaccg ctaaggcata tgaaatcgta tcaccgccag atccgccgta 1751941 ttcttctgga aatggaatac ccatcagacc gagttcaccc atttttttaa atgtttgcat 1752001 cgggaactcg cctgtttgat ctacatgttc agcgtgagga gcaatttctt ttttcgcaaa 1752061 atcttttacc atttcacgca ccatttgttg ttcttttgtc agctcaaaat tcacatcgtt 1752121 tcctccttca catctttgta acatcctatt aggcgagttc tataatcatt ccctgacaag 1752181 aaaagtctga aaattaaaac tgaatcattt tttatgtgat aatatcagcg ggatgagcaa 1752241 atacatgcag taggcgcata ccatccatat cgtaaacgca ataacttggc cctttgataa 1752301 agccgggaag atgaggggaa gattccaaag ggaaatcgta tccatcaata aaccgaccgc 1752361 tgatccccat atacctagct tgatcaccgc gaactgtgat tgatcgagtt tttgatagag 1752421 aaagaacaca aggcataaaa caagagcagt gcccgctccc aagagaagaa agttcggcaa 1752481 aaaggcttct tcagccggat cagtcaacac agcatctccg aacagcacaa aaaataatgt 1752541 ggcacctaac cagactagaa atgaaaacgt aaaacacgtc ctgtacgtgt ttctcttcga 1752601 ttttattttt atttagtact agtttctcag attccaataa tggtaaatgt ccaaacaccg 1752661 cctccatatt catgtgaatc tcacctttgt tttttaaaaa attcagcggt ttaccatcgt 1752721 ttcctgtccc aaaatcactt tttaaaaaaa gacgacttag aaagccgtcc ttctcatttc 1752781 ttattttgtt gttcgtttgg aagctttgct ttcgttatga agccggtctg ctgaagtgac 1752841 ataatacgta tatttcttgt tgggatctgc cgtgttatct aagaaggttt gctgctcatg 1752901 tgtttttctt tgcgttgcca gcaatgttct ctgctttttc ccttcggctc tgtatatcgc 1752961 ataataggct gtttctttcg ttttttgatt tgatgggtga tctttaatct gcagaagatt 1753021 gccgtttttg tcttcggtga ctttcgtaag cttcggtttt tttggggcgg tattgtcaag 1753081 ccaaggcatt tgcggaacca gtgccggctt gctgtaaaga tcggtgctga gactgtcttt 1753141 gatgccaagc ggatttttgt tgaggtcctt gaggctgaaa tgcatgcttc ctttcaccag 1753201 ttcaagctgg cggttcaaag tgatttgccg cacatattcc tcaggatcgg accaaggcgg 1753261 atcaaaattg ttattgattt tatatgctgc ctggccaata tataagtgaa caggcctatt 1753321 tttgacttca ttgctccacc aatcagccag cacgtcgtaa gccgctgcgt taaagccgat 1753381 actccaataa atttgcggag caatataatc gatgtcgcct tcttggatcc aatgccttgt 1753441 gtctgcatat agatcgtcat aatttctgac gcctgctttt gtattcgatc cggtcgggtc 1753501 atctgcggcg tttctccata ctccaaaggg actgatgccg aatttgacat acggttttgc 1753561 agctttaatt gtttggttga tttgtttgac aagctggttc acattgtccc gccgccagtc 1753621 atcgatatta gaaaaagcgt cttttccgta ttgttcgtac tgtgcttgat caggaaattc 1753681 ctgtcccgct attttataag ggtaaaaata atcatccata tgaacagcat cgatatcata 1753741 atgttttacg acttcttcaa tgcctttgac gataaaatct ctcgcttctg gaatgcctgg 1753801 atgataatac agctggtttc cataggcggc aacccaatct ggatgttttc ttgccgggtg 1753861 atcctcagac aatttattaa gatctgtatg attcattgta atacggtaag gattaaacca 1753921 cgcgtgaaat tccaaatttc gtttatgggt ttcttcaatc ataaatgcaa gaggatcata 1753981 gccggggtcc ttcccttgga caccggttaa gtattccgac caaggcccgt aagctgacgg 1754041 ataaaaggca tcagccgtcg gtttaatctg aacgataacg gcattcattc ccattttttg 1754101 cacatcgtcc agcagtttga tatactcctg tttttgctct ttcacagata accctttttt 1754161 ggacggccaa tcaatattta atacggaagc aatccatacg gctctcagct ccctgtcaga 1754221 ctgcgcattg gccataaacg gaacggaaat gacaaacgtt ccgatgatca agctgacaag 1754281 gaaacggaca atcgactttt ggcaaacctt cattctgttt cttctccccc attacatcac 1754341 tttcactatt cgctattacg gtattcccgg gctataaaag ggtgattaac agaatgtcta 1754401 tctcactaaa taaacgaaaa aagtcctaaa gcatgttgtg aaccgctttt aggacttttt 1754461 atcattcatc atggtttgca gactttttaa cacatcaata agttttacgc cgacaccgac 1754521 agccgtttca aggatcgctt gtgctccggc aatggctaaa ataaagatca gcggtattgc 1754581 aatacgaggc aaaaaaagat agccaagtcc gatcaagatg gcacaccaaa caccggcaca 1754641 ccagtagcaa ttgagcatgt atccaaagtt agaagccggc acgctttttt catctacatg 1754701 cccgttttga tcaacaatcc ttttcttttt cataaaaggt tttcggataa attctgtgat 1754761 tttgtcaaat acaatcaaat gtgtcagcct gtaactggct agaatcagca tgataaaagt 1754821 tagaaaagaa agacggtcca ttgagaagcc tccaagaaaa aggatgatgt tatcattccc 1754881 aagtgtccct tatccattct tgatacaaaa agaaagacgg acagagaatg gcctctgtcc 1754941 gctaatccga gctcattccc tccagttctc ataataagag gataagaaaa tgtagaaaaa 1755001 agcagaaaaa tgacaataaa agaaattata tgactatata atccatatat gcactatatt 1755061 aacggatatt ttttaaagta caataaaaaa cattaaattt ttataacatt ttttttgaat 1755121 atagtattat ttctttattt ttcgtttctt tttttatcaa atttccggat ataaagtgat 1755181 aaaagtattg ttttacataa ggtcttatac actacttttt aatcggacta attttctttt 1755241 gtgcatcatt cttctaattg ttggaaggtt cgacaaagcg ttattacaga cataaaaaaa 1755301 cctgttttct cttggaaaac aggtctcccg ctattattga tttgccaaaa tgacagcgat 1755361 ttgatcctca atatcttttc catcctcttc atcaatcaat ccatttagaa gaatagagaa 1755421 aacaagtttt tttccgctct ttgtttctgc gtaccccgat agagagctta ccgtactgag 1755481 cgatccggtt tttgctctta cttttccttg tgcaggagtg cctttcatgc ggtttctcag 1755541 cgttccgccc accattctgt caggattccc cgcaacaggt aaagaattta gataagccga 1755601 gaaccaactc tgatcctgaa tgtcatataa cagctgtgaa agttgatctg aggatacagc 1755661 atcaatatgt gagattcctg atccgtccct taagacgagt gatttagaat caacaccaaa 1755721 ttccggaagc gtactgttta acacttcgag ccccttttcc cagctccctt ctcctttttt 1755781 cactttcccc atctctttta cgagcacttc ggcatgtccg ttattactta atttcatgaa 1755841 cggcacaaaa agtttcgata aaggcattga gcgatgagag agcagcacat ctgaagaact 1755901 aggtgcttca cccgtcttga tgtccccttt cacagtaata ccttgttttt ttagtgactg 1755961 cttaaataaa tctaaggcat atccggcagg ctcccagaca gaaatccatt cctttgtctt 1756021 gtttgcgtca accggtacgc tcccttcaat tgtaatcgtg tttgttccat gctctctttc 1756081 gattgtgagg tctttctctg aaccggcagc agtcgtttta gcatcgttct ttatcgttat 1756141 ataatcggtt ttcggagaga cagacacggc aggctcttcc ccttcttttt gatttggggt 1756201 gacctcaaca atcacagtgc ctgcatcata gtcttcgttt ggagacgctg ttagagcgga 1756261 gattggcgcg ccataatatg tgtattcatc gctccaaggc atatcaggtg ataatcgcat 1756321 gtcatcatgc cacgtatcat caccgatcag attgccttta attactttta cgccggaatg 1756381 tttcaatatc tcagccattt tgtcaaaatc agatggtaaa agtgtcggat cgcctttccc 1756441 tttcaaataa aggttaccat tcagcttttt ccctttcagt gttccatccg tccggacctc 1756501 ggttgtaaaa gaatagttct cgccaaggac agaaagtgcc gcggccgctg tcaaaagctt 1756561 tagagaagag gcaggcctca ttcgggtgtc tcctgaatgt tcatatagaa cagcacctgt 1756621 ttccgcagag cgaacggtga tgccggccat tgcgccttcg agggcaggat gatcagctaa 1756681 aatcttatcg atctgcccgg aaagtgcatc ttgtttttca gcggcaagcg cagcctgatg 1756741 catataaggc accgaagcaa cgacgaaaag cagtaaaaca gcaacataaa gctttatgct 1756801 ttttttcatt aatttccccg cctctctgcg cttcatcatt ggctattgat gattcagttc 1756861 aatggtgata ctgcttttag ctgtcgtttc ttctcccggc tccagcactt gtaaaccagt 1756921 gagtgacgaa ggtaaatcaa gattcactgc gtttgtcacc catgtgtaag gctcagggca 1756981 taaataccct tgttttccgt ccgcattgta tacaacccaa tgtttaaact gttcatctgc 1757041 cttataaata atgctgatat gtgcatgctg atgataaatg actgcctggt tttctccgcc 1757101 cctcttctga taagaagata aaaagacatc atccagctgc ttgtggcgca aatccattcc 1757161 ttcatgcaaa gcttctttat acgggacatc catcagcttc ccggtcggca gcaggcgttc 1757221 atccaactcc cattgctgat ctgctgtcag ggagaataac gagctttctg ccggaaatat 1757281 aaatgtagta tgataaccaa ttccccaagg aaacgcttcc tttcctttgt tcatgaccgt 1757341 cgcatgttta aatagggtat tctccttgat cgtgtatgtc atccgaacga cggcatgatg 1757401 aggaaattgc ttctgcacat ggggaagctc agaaagatca atttctgttt caacaatcac 1757461 tccttcatca gtttgcttcg tggtcacgac attccacttt tcatggtaaa gaaacccgtg 1757521 aagatggttg tgtttatcct tctcgttgat atcaaaatga tacgttctgc cccggaaact 1757581 gaatgtaccg tcacttatgc ggttaggcgg gaacaggatt ggaatgccat acaatgttgg 1757641 tgtgtcgtga aaactttctg ctgtttccgg ttcacgcaaa agctggacat ttgttgtttt 1757701 gtccacgaga gaaatgacgt tgctccccca ctcagggaca acaatcattt ctagatgttc 1757761 gttgcccgct ttgatggccg gcgttcccaa atacgtgatt ttctcaataa agtttgccat 1757821 gtttactcaa cctctccttg attcattgct agtataagaa ttcaatgtac tgtaccatat 1757881 ttcctccatt ttatattttc ccctatcaaa taaaaaaaca ccgttcaaac ttatgaacgg 1757941 tgtgattcgg aggctattgg atgagacgtg tgatttgttt ctttttccag acgaattgat 1758001 aatacccata aatcaacagc aagctgacgg caaacgcagc tggataacca acccagacgc 1758061 cgagtatttc aagctttgta tagtgagaaa ggacgaaagc gacaggcacc tctactcccc 1758121 agattgcaaa aatactgatg acggtcggcc ataaaactgt tccgcttgcc cgcatcgttg 1758181 cagaaataat ttgggcattt ccaaacagca aatagctcca cagtgtaatc atcaaaagac 1758241 ggtgcgcaat gtaaagcgtc tcttgctcgg ttaaaaataa cgataaaatc tgatgtgaaa 1758301 aaacatagat cagaatgatc agtacgccgc caatgatata attcagccaa atcccaacgc 1758361 gaatgacctg ctttaagcgg tcaaactcgt ttgctccgat cgattgcgca gcgaaaatag 1758421 aaaccgcaat accaaggctg acggccggca tctgtacata gctggccacc tggttgacca 1758481 ctccgtatgc agctgttgca ttagagccgt aatgattgac gaatgaaata accgctatct 1758541 ctgataatga gacaagaatc atattgatgc ttgctgggac cccaagacgc agcaggagaa 1758601 ccagcagttc cttatccatt ttcaaataac gacgcactgt tttatcaaat tgcagcgggt 1758661 gttttcgctt tcgtaaatac accattaaca cgagaaaagt cgcaatcgtg gaaatgacag 1758721 ttgcatatgc cgagccgtat atgcccagtt tcggaaaacc aaacatgcca aggattaaaa 1758781 caggcaaaag cgcgatgttg atgaccgtgc tcacaatcag cgtataaaac ggtgtcttgg 1758841 aatctcctgt tccgcgcaaa aaggtagtat atgcaaaata taaaaacata aacggcatag 1758901 cataaaataa aatacgtgca tagttagcgc tgacatgaat gacattttca ggtgttccca 1758961 ttaaacgaag gatatccagg gtgaaaatac tgccgataac ggctaacaca acgcctaata 1759021 aaaatgtaaa cgtgagtgtc gtcccgacaa cagcctttag ccgttcctca tttttcgctc 1759081 cgtaagcttg tcctatcaga atcgaacttc ctgaaccgat cccaatcgta aatgagatta 1759141 aaagaaaaaa taacgggaaa aaggatgata cagctgccac tgcatcaaca ccgagccatc 1759201 tgcctacagc catcatcccg actagctggc cgactgattg cagcacattg ctcagcagaa 1759261 gcggcactaa aaagagtgac atcgaccgcc aaactgatgg tttgcttttc ttttgagtta 1759321 caagaggttc ttgtgatgtt tccatattaa aggactcctt tatttgaaat cgtttttaaa 1759381 catgccctca ttttttgaca aaaacaggat atgtaacatg ttattattca tcactgcact 1759441 tatgaaaccc ttcccgattc ttctaatttt acacatcttt ttagcttatg aagaataaac 1759501 tagcaagtaa tggcgtattt tttgtgagta aaagaataaa aaataattta tgcaaaagta 1759561 ttgtaatcta tccgtaatta ttgtaacatt tgtaacataa gagaaagaga ttttgaagga 1759621 gagagcgata atgaaaaaat gtcttctatt tctaacaacc attgcactta ttctgtcatt 1759681 aagcacaaat gcatttgcga aaaatacatc aggcgattta tcacaaaaac aagcattaca 1759741 gttggcatta tccgctagag aacatttttg gaacaccatg agcggccaca atccgaaggt 1759801 gaaaaaagca gtttgcccat caggcacatt cgagtatcaa aatcttcaat atgtatacat 1759861 gtgcagtgat ctaggcacta aagcaaaagc ggtgaattat ttaactccta tttttacaaa 1759921 aacagcaatc gaaaaaggct ttaaagatta tcatttcact gtttcaaaag gaaaacttgc 1759981 tgttccaatc ggtgacggag acaatctttt gaattggaaa aaatcaactg ctaaactgat 1760041 ctctaaaaaa ggcagcacaa tcacatacga atttactgtc cctacattag acggatcccc 1760101 ttctgcaaaa cggaaagtga catttgtgaa agaaaataaa aaatggaaag tcaatcaatt 1760161 tgacgcagtt atataagaaa aacgcccggt ataagcgggc gttttttatt tggtttgcat 1760221 aaagaaagac aacaggcgaa aagtgcctgt tgtctttttg tgaatataac gctctaggag 1760281 agattcgaac tcccgacctg cagtttagga aactgctgca ctatccgctg tgctactaga 1760341 gcttttggta tttatatagt agctctgatg atcaatattt tcaagcgatt tgtattaaag 1760401 ccctccaaaa accttatatg cggctcttgt cgtatcttca tcaataccga tataccgcat 1760461 tgtaattgat ggtgatgaat gattcagtat tctctgcagc tcggcgatgt ctttcgttcg 1760521 ctgataaaaa tgatagccaa acgttttccg gagtgtatgc gtccctatct cctcaagtcc 1760581 gcacgctgca gcggcctctc ttaaaattct gtaggcctga atgcgggaaa tcggcttcct 1760641 ggtccgcact gatttaaaaa gatattcgtt ttccttcatg tctttcgtat actcgtatat 1760701 ttcctgtttc agcgattcta aaataagaat ctttcttttc tttttcgttt tgctttcagt 1760761 cgcccataaa tgatctttat tttgaacgtc cttcacttgc agcggcagaa tatcagaaat 1760821 acggagcgcg ctgttgatgc cgaaaataaa cagaaaataa tcccgcttgt ttttgttaag 1760881 caaatactgt ttgacttctt ggattttctc tagactgcga atcggctgta caatatgcat 1760941 caaaaaactc cttaaaaacc gttatgtaac attttgaggt ctatgttact attatagctg 1761001 aaaaacgttg aatgtcaaag tgcggcggcg tttatgtaac ataatataca tagtgttaca 1761061 taagctttta aaaaagcttc ttccaacctt caccctataa aataagcttt aaagcctctt 1761121 ataaagcttt taacctcttg gatacttatc cccctactaa tcatcaaaaa acctcttaaa 1761181 atgaaatctg acactcccaa ttttctggag cttccgcaaa aatatacaaa aaaagacaca 1761241 atttcaaatt gtgtcctaat cctcatcctt tacatcaata tcttccggga tcggttcatt 1761301 taatatttcc tgcacaagtg ctttgtaatt ctccagctgt tcgagatgcg ttttgaactg 1761361 ttccttataa atcaaaaatt gctccccgtc atgaacggct ctgattttcc cttcgagcac 1761421 caagctttta atataatcct ctgaaagatt tgtatattct gctgtttctt caatcgttaa 1761481 atacatatag cagtcccttc ttaatccgta tgctgattct aatatagcac atggctcata 1761541 tcaatataat caattctgca cagaaaaacg gcattatgca ctatataata taccatttgt 1761601 cacttgtgaa aacgctgtaa tttttttacg ctaagattgt aacaatacag cttcatatag 1761661 gagggagaac atgaaaagaa cgtggaacgt ctgtttaaca gctctgctta gtgttctgtt 1761721 agtcgctgga agtgtccctt ttcacgcgga agctaaaaaa ccgcccaaaa gctacgatga 1761781 gtacaaacaa gtagatgttg gaaaagacgg catggttgcg accgcacatc ctcttgcttc 1761841 tgaaatcggt gctgatgtgc tgaaaaaagg aggaaatgct attgacgcag cggttgccat 1761901 tcaatttgca ctcaatgtaa cagagccgat gatgtcaggt attggcggcg gcggttttat 1761961 gatggtgtat gacggaaaaa cgaaggatac aacgataatc gacagccgtg agcgtgctcc 1762021 agcaggcgca actcctgata tgtttctgga cgaaaacggc aaagcaattc ctttctctga 1762081 acgtgtaaca aaaggtactg ccgttggtgt tccaggcact ctgaaagggc tggaagaagc 1762141 cttggataaa tggggaaccc gttcgatgaa gcaattaatt accccttcta ttaaactcgc 1762201 tgaaaaaggc tttccgattg attcggtgtt ggcagaggcc atttctgatt atcaggaaaa 1762261 gctttcacgg actgccgcaa aagatgtatt tttaccaaat ggcgaaccgc ttaaagaagg 1762321 agataccctt attcaaaagg atttggctaa aacatttaag cttattcgct ccaaaggcac 1762381 tgacgctttt tataaaggaa aattcgccaa gacgctttct gacactgtcc aggatttcgg 1762441 cggatcaatg acagaaaaag atttagaaaa ttacgacatt acaattgatg aaccgatttg 1762501 gggagattat caaggctatc aaatcgctac tactcctcct ccaagctccg gcggtatttt 1762561 cttattgcaa atgctgaaaa tccttgatca ttttaacctt tcacaatacg atgtccgctc 1762621 atgggaaaaa tatcagctgc ttgctgaaac gatgcatttg tcatatgccg accgtgcgtc 1762681 ttacgcaggt gatcccgaat ttgtaaatgt tcctctcaaa ggcctgcttc accccgatta 1762741 tattaaagaa cgccagcaat taatcaacct agatcaagtg aataaaaaac cgaaagccgg 1762801 tgacccttgg aaataccaag aaggatcagc aaactataaa caagttgaac agccgaaaga 1762861 caaagtagaa ggccaaacaa cccactttac agttgctgac cgttggggaa atgttgtttc 1762921 ttatacaaca acaatcgaac agctattcgg aacgggtatt atggtccctg attacggtgt 1762981 tattttaaac aatgaattaa cggattttga tgcgatacca ggcggagcta acgaagtaca 1763041 gccaaacaaa cggcctttaa gcagcatgac cccgacgatt ttatttaagg atgacaagcc 1763101 tgtcctcacg gttggatctc ctggcggggc cacaattatt tcatccgttt tgcaaaccat 1763161 tctctaccac attgaatatg gtatggaatt aaaagcagct gttgaagagc cgagaattta 1763221 cacaaacagc atgagctctt accgttacga agacggagtt cctaaagatg tcctcagcaa 1763281 gctaaacggc atgggccaca aattcggcac aagtccggtg gatatcggaa acgtgcaaag 1763341 tatatcgatc gaccatgaaa acggcacctt taaaggtgta gctgattcaa gcagaaacgg 1763401 cgcggcgatc ggcattaatt taaaacgtaa ataaataaaa aactgtactc gcttcaaatg 1763461 agtacagttt tttcatgcag atctttaaaa taaaaactga caaacgtctt tattctgcta 1763521 atgcacgtct atcttcatct tttcatttcg tttatctcat caagaaatgt ctgaaacgca 1763581 ctcgtaataa aaaagtcttt cctgtatata aagacgatct ctaagtcttg atatgatggt 1763641 ggcagctgat gaatccatac atttgtacga tgctcggagc cgtcaacagc ggactttggg 1763701 agcagcgccg tacccatccc ggcggaaaca ccttttataa tagcctccaa tgtgccaaac 1763761 tctatgattt tttgattgtg tatgcctgct tcctctagta atcttttgac cctgtcacga 1763821 tgagaacagc cagccccaaa aaagagcatc ggctgctgaa gcatgtcttc tgccgtccct 1763881 tctcgtgatg aaatcaaaac taattcatca tgggagacat ggagttgtct aactgcagcg 1763941 tgttcaaccg gcccatatac aaaagcgcca tcaactttat gatcaagaac ctgttgaatc 1764001 aaatgatgcg tatcagctgt gttcactgat aaatccactt caggaaaacg cctgaggaag 1764061 gatgctgcat gctcaggcag atgcgttacc gccattgttt ccagtgatcc gatccgcaaa 1764121 ggcccttttg gttgcctgct cattcgggtc gatttttcag cttggtctaa cagcgataat 1764181 acttgatctg catattgtaa aagattttct cctgcagcag tcagcttcat tccccgattc 1764241 gttcgatgaa aaagcctgat attcaaatct tcctcaaggt tatgcactct ggctgtcaca 1764301 ttcgactgaa cataattcag catttgggct gctttcgtta tgcttccttc gcgagcaaca 1764361 gcctgaaaaa tctttaaatc tccgctttcc acgcgctctc acctgcttgc tatgatgaaa 1764421 agtgatattg gctatcatat ttgttcattt tactcgaaga aaaccgctat gtaaaatatg 1764481 taaagatatg aaaatacaat taatgaggag gcagacagca tgaaagctgt aattcacaac 1764541 ggaaaagccg gtcttctggg gttatcagtt caggacgttc catcaacaaa gcctggatac 1764601 ggagaggtaa aggttaaatt aaaatctgca ggcctgaatc atcgtgactt gtttcttatg 1764661 aaaaacaaat ctgaacaaga tcctcacatg atactgggtt ctgacggcgc gggtatcatc 1764721 gaagagattg gtgaaggcgt gaaaaatgtt actgttcaga cagaagtagt cattttcccg 1764781 acattgaact gggatttgac agaaaatgtt ccacctgtac ctgagattct gggaggtcct 1764841 tcggacggaa cacttgctga atatgtgatc attccttcac aaaatgcaat caaaaaacct 1764901 gcttatttat cttgggaaga agcgggcgtt ttacctttat ccgctttaac tgcatatcgg 1764961 gctctgttta caaaggggca attaaaaaaa ggcgagcatc tattgatacc cggcatcggc 1765021 agcggtgtag caacctacgc tttatttatg gctaaggcga ttggggcaac agtaagcgtg 1765081 acctcccgca gtgaggagaa aagaaaaaag gcgctgaaat taggtgctga ttacgcattt 1765141 gacagctaca gcaattggga tgagcagttg cagggaaaaa agatagatgt tgttcttgac 1765201 agcataggac ctgccctctt ttcggaatac ttccgccatg taaaaccaaa tggccgtatt 1765261 gtcagctttg gggcaagctc aggggataat ctcagttttc cggtgcgttc tttattcttt 1765321 cctcaggtca atgttttggg aacctcgatg ggaagcggtg aggaatttca agctatgctc 1765381 gctttcattg acaaacataa gctgcggcct gtaattgacc ggatatatcc tttagaaaaa 1765441 gcatgtgaag catataaaag aatgcaggaa ggcagacagt ttggaaacat cgggatcgta 1765501 atggaataaa aaaagaaacc ggctggcagc cagaccggtt tctcttatat gataatcccc 1765561 tttatttacg gaagaactga actccccatc aaatatcgat ccacttcacg cgccacttca 1765621 cggccttcat taatcgccca tacgattaag ctttgccctc ttcttgcatc ccctgcggcg 1765681 aatacaccat cgatatttgt ttgataatcc ccatatgctg cactgatttt gttatttact 1765741 gaattaacac cgaactgttt caacagcggc tgttctgtgc cttcaaagcc gatagcgata 1765801 aagacaagct gagcaggcca tactttttcc gttccaggca gctcgcggaa ctcgtatttt 1765861 ccatgctcat ttttcacttt ttccatttgg atggtatgaa gctctttcag ctttccgttt 1765921 ttatccgcga ccatttttgt cgtttgaatg gagtattctc tcggatctct tccgaatttt 1765981 gcttctgctt cctcgtatgc atattcaagc gtaaagacgt gtggctgttc aggccacata 1766041 ttgtcattcg tgcgggctgg cggaagtttc gggtgtttgc cgaattggtg cacgcttttg 1766101 gctttttgac gcagagcggt agccacacag tcagctcctg tatctccgcc tccgattacg 1766161 atgacatctt tccctttggc atcaatgaat tgcttgtctt taaaattaga atctaaatag 1766221 ctttttgttg caagtgtgag gtagtccatt gcgtaatgga ctccttttga gtcgcgtcct 1766281 tcgattaaga ggtcccgctg tttttgagcg cctgtgcata agatcacagc atcaaattgc 1766341 tcctttagct catcagctgt aatgtcaaca ccgatttctg tgttcgtgac aaaatcaatt 1766401 ccctcttgcg tcagcaattt aattcggcgt tctacaatgc ccttctcaag cttcatgttt 1766461 ggaatgccgt atgttaaaag gccgcccgct ctgtctgctc gttcaaaaac agtgacggaa 1766521 tgtcccgctt gattcagctg gtcagcactc gccagtccgg ctgggcctga cccgacgatg 1766581 gccacttttt tgcctgttcg tttttttgga attctaggtt gaatccagcc gttctcaaat 1766641 cctttatcga taatggtccg ctcgatgttt ttaattgata cggccggatc tgaaatcgct 1766701 aaagtgcatg atccttcaca aggagcgggg catacccgcc ctgtgaattc aggaaagttg 1766761 tttgttttca acagacgttc caatgcttcc ttccatctgc cccggtagac aagatcattc 1766821 cattcaggaa ttaagttgta aatcggacag ccggatgtaa atccgttaat gtccgcaccg 1766881 atctggcaaa acggtgtacc gcaatccata caccgcgccc cttgccgttt cgatgcttct 1766941 tctgaaaaag gagcagaata ttctttccaa tcctttaagc gagtgagagg gtcccgctcc 1767001 gcaggttttt ctcgtttgat ctccataaat ccagttggtt tccccatgtt cctctcccct 1767061 tccttactgt actaccgctt gtttttgtcc cgatgctgct gtattctgct ttggcttcgt 1767121 gttggcctca aaagcgaaca tgatggcttc ttcatctgat aaacctgcag ctttttgctc 1767181 ttcgatgctt gcgagcattt gtttatagtt tttcggaatg actttgacga attttttcac 1767241 actgtcttcc cattgatcta gcagatcttc tgctttttgg ctgtttgtat acgcagtatg 1767301 tctttcaagc attgctttga tttgctggat ttctttctca tcctctaatg attcaaataa 1767361 aatcatctca aggttgcatt tgcgtttaaa cgctttgaca tcttcggtca gtacataagc 1767421 gattccgccg gacatacctg ccgcaaagtt tttgcctaca tcaccgagaa cgacaacgct 1767481 gccgccagtc atgtattcac agccgtggtc gccgatgcct tctacaacta cgttcacacc 1767541 gctgtttcga acggcaaagc gttcaccagc acgcccgtta atatatgctt ctccgcttgt 1767601 cgcaccgtaa aaagccacgt tgccgataat gacattgtca tccgaagcag agttgaatcc 1767661 ttctgatgac ttgacgatga tttttccgcc agaaagccct tttccgacgt aatcatttga 1767721 gtctccgtcc aaataaagcg tcatcccttt aggaacgaaa gctccaaagc tttggccggc 1767781 tgatccggta aagtgcagct tgattgtatc ttcaggaaga ccttcttctc cgtaacgctt 1767841 tgagatttca ctgccggtta tcgttccggc tacacgattt gtattattga tttcaatcga 1767901 aatatcagct tcttttccag attcgatggc ttcttgtacg gccgggagaa ttgttgtaat 1767961 atcaagtgat tgatcaattt tatgattttg cggcgattgg aacgtccgca ccccttcagg 1768021 ctgataaaga agggtagaca aatcaagctg gcttgctttc cagtgctcct ttgcccgttc 1768081 acttgcatga agtacatcag tgcggccgat catttcatca aatgtcttga agcctaacgc 1768141 agccatgtac tcacgaactt cttcggcaat gaacagcata tagttcacaa tatggtcagg 1768201 atctcccatg aactttttgc gaagctctgg attttgtgtc gctacaccga cagggcatgt 1768261 atccaaatgg caggcacgca tcatgacaca gccgagtaca actaacggag ccgttgcgaa 1768321 accaaattct tcggcgccga gcaaggcagc catcacaacg tcgcggcccg tcatgagctt 1768381 tccatctgtt tctaatacaa cacggtcacg aagtccgttc agcattagtg tttgatgtgc 1768441 ttctgcaagg ccaagctccc acggaagccc tgtatgttta atactggttt tcggagaagc 1768501 gcctgtacct ccgtcatagc cgctgatcac aatgacatct gcagtcgctt tggcaacacc 1768561 tgcagcgatt gttcctacac ctgcttttga caccagcttt acgctgattc ttgcgtcacg 1768621 gttggcattt ttcaaatcgt ggatcagctg ggctaaatcc tcaatcgaat aaatgtcatg 1768681 gtgtggcgga ggtgagatta atccgacacc tggcgttgac ccacggacat cggcaaccca 1768741 tggatatacc ttgttgccag gaagctgccc gccttcaccc ggcttagcac cttgagccat 1768801 tttaatctgc agctcatcag cattgacgag gtaatggctt ttgacaccaa accgtccgga 1768861 tgcaatttgt ttgatcgcac ttcttctatc atcgccgttc tcatctggaa caaagcgttt 1768921 gggatcttct ccgccttcac cgctgttgct ttttcctcca agacggttca ttgcgattgc 1768981 taaagcttcg tgcgcttcct tactcaagga cccgaatgac atcgcacccg ttttaaaacg 1769041 tttgacaatc gattcagcgg attcaacctc ctccaacttc aaaggcttgc ggtttccgtc 1769101 aaatgcgaac aagttccgca aaaatccgat gcgttcttca tcagccgctt ttgtatactg 1769161 tttaaacaga ttgtaatcat ttctgcggca cgcccattgc aaagtatgaa tcgttttcgg 1769221 attaaacgca tgatgctctc cgccatttct ccattggaag tcacttcccg gttcaagcgt 1769281 tttgctgtaa tcatcctgat acgcttcccg gtggcggcgc tgtgcctctt ctgcaattgt 1769341 ttgtaaatcg atgccgccta gctgtgatgc agtacctgag aaatagcggt cgatcacatc 1769401 gcggctgatt cctaccgcct caaagatttg tgcgcctctg tagctttgca cagttgaaat 1769461 tcccatcttg gacatcactt ttacgacgcc ctcagtaatg ctttttccat atttgctaac 1769521 cgcttcttca tagctgatat ccaaacggcc ttcatcaatt tcctgcttgt aggtcgcata 1769581 agcgagataa gggttaatcg catctgcgcc ataaccgatt aacgctgcaa agtgatgcac 1769641 ttcacgtgct tctcccgatt ccacaataat gctgaccttc gtacgcagcc ctttgcggat 1769701 taagtgctgg tgcagtgcgc ttactgccag aagcggcgga attggtgtca gtcgttcgtt 1769761 catctttttg tctgataaaa ttaacaaact tacgccttgg ctgatggctt tctctgcctg 1769821 tgtgaacatg tcctttaaac cgcgttcaag atcctctgaa aacagcacat caattttttg 1769881 gctttttaaa tcaggatgaa caatcgtttt caatgcgtaa aactgttcat tggataaaac 1769941 aggtgtatac agtttaatcc ggcgaacatt tcgttcactt ggatgaagaa gatcgccttc 1770001 cgcaccgagc caagtcatcg ttgaagtgac aagctgctca cgaatcgcgt cgattggcgg 1770061 gttcgttact tgtgcaaaca gctgtttaaa gtagttaaac agcgattgcg ctcggtcaga 1770121 aagtacagca agcggagcgt cattccccat tgaaccaagg ggatctttgc cttctttaat 1770181 aacaggaatt agatactttt ggatatcctc atatgtgtat ccgaatgcct tctggcgagt 1770241 aagaagatca ctaaattgtt cttcttctct tgactccgga tcaggattta cttgtacaag 1770301 ctcttcttca agccattttt ggtacggata ctcagttgca atttgtgttt tgacttcctc 1770361 atcggagata atacggcctt cttccaggtc gattaaaagc attttcccag gctcaaggcg 1770421 gtttttatat aaaacgttct cctgttcaac ttcaataacg cctacttcag atgagaaaat 1770481 aatataatca tcttttgtga cataataacg ggccggacgg agaccgttcc ggtcaaggat 1770541 cgccccgatt tgtttaccgt cagtaaatga aatagctgtc ggtccgtccc aaggctccat 1770601 cagggagcta tggtactcgt agaacgccct tttttccttg gacatatgcg tattttccgt 1770661 ccaaggctct ggaatgagca tcattgccgt atgtgccggt ttgcgtccag ccatcacaaa 1770721 aaactcaaat gcgttatcca aaatggaaga gtcactgcca tcagcattga gaatcggcaa 1770781 aatcttgttt aagtcctcac cgaagctttc agaaacaaat tgctgctcac gtgctctcat 1770841 ccagttgata tttccgcgaa gggtgttaat ttcaccgttg tgaaccaaat agcggttagg 1770901 atgcgctctt tcccatgtag ggaatgtatt ggtactgaag cgtgaatgaa caagcgcaaa 1770961 agcagaaacg aatgcttcgt cttgcagatc agaataaaat gcatcaacct gttcaggtgt 1771021 taaaaggcct ttgtaaacaa tggtctggct tgaaagactg gcaaaataaa aatcaagacc 1771081 ttccgttact ccccaatttt cagcctgttt acgaatgaca tacaattttc gttcaaaaga 1771141 taaattgtcc tttagatcag aacttgcgcc gataaatacc tgacggacaa acggacagct 1771201 tttttgcgcc actgttccga tttttccgac atttacaggt acagttctcc atccaagaac 1771261 gacttggcct tcttgttcaa ttagtgcatt gatttgcttt tcaatttttt ttctttcatc 1771321 ttccttctgt gagaaaaaga ccattcctac cccgtaacgt tctttttctg gcagattgat 1771381 gtttttgcac tcttttctaa agaaagcatc agggatttga accagtaagc cggctccgtc 1771441 tcctgtatcc ggatcactgc cttgccctcc tctatggtct agctggcaaa gcatcttaag 1771501 tccttgtttg acaatgtcgt gagtctgctt gccctttaag tgtgcatata ggccgattcc 1771561 gcatgcatca tgttcaaatt caggacggta gagaccttga gcttttggca tttgattgta 1771621 cgtcataatt cctctccccc gatcaatttc cgataatacc ggtcataaaa tctaacaact 1771681 ctataatcat tgtaggtttt caaaacgata taaacaatat ataatttaga tcaaaagaat 1771741 ctcaaaatga gatagatgga tgtgagacaa acatggagct gcgccaactg cgttatttta 1771801 tggaggtggc tgaaagagaa cacgtttcag aagccgctga tcatttgcat gtggcccaat 1771861 cagcaatcag cagacaaatt gccaatcttg aagaagaatt aaatgtgacc ttatttgagc 1771921 gtgaagggag aaatatcaaa ctcacgccaa tcggaaaaga atttttaatt catgtgaaaa 1771981 cggcgatgaa agccattgat tatgcgaaag agcaaattga tgagtatctt gacccgcatc 1772041 gcggaacggt aaagatcggc tttcctacaa gcctcgccag ccagcttttg ccgactgtca 1772101 tttcagcgtt taaagaagaa tatccgcacg tcgaattttt gctgcgccaa ggctcctata 1772161 agtttctgat tgaagctgtc agaaaccgcg atattgatct ggccttatta gggccggtgc 1772221 cgacgaattt ctctgacata acgggaaaaa tattatttac tgaaaaaatt tacgcgcttg 1772281 ttccattaaa tcatccgctt gctaaacaaa aaacggttca tttaatcgat ttgcgcaacg 1772341 accaatttgt attgttcccg gaaggatttg tacttagaga gatggcaatc gatacttgca 1772401 aacaagcagg ctttgctcct ctcgtttcca cggagggtga ggatttggat gcgatcaaag 1772461 ggttagtgtc cgcaggaatg ggcgttaccc ttctgcctga aagtactttt gctgaaacaa 1772521 cacctcgttt tactgtgaaa attccaattg agttccctca agtaaaacgg actgtcggaa 1772581 tcattaaacc gaaaaataga gagcttgcgc cttccgcgaa tgatttttat gagtttgtca 1772641 ttcaattttt ctctaagctg gagcagtatc aataaaaaaa atgaacccga gcttctatat 1772701 agaagcttcg ggtttttttc tgcaaattaa tttacaggta aagaaaaatc cacatggcaa 1772761 acaaatgctt cttgatcaat tagagctcta tttgtcagtt cctttttctt ttccggttct 1772821 tgaagctgta cagaagagta attgacgatt ccaaggccga tttccgtccc ttttgaatcc 1772881 atcagccgaa caactgaacc gcttttgaat ttccctttaa tcttctgtac accgtctagg 1772941 tataaactcg attgtccgtt tgttattttt cgtgaacaat catctgataa aatcatttca 1773001 ccttccggac cggaattaaa agcgatccat tgctcctttt gattcaacgg aagcgttcct 1773061 tctgcttcaa aataggtgcc ttccgcctgt tcatgaacgg cgtggtataa aatatcgcca 1773121 gcatctgcct gacctaggaa acctttaatg ccagacgcca ttacgatttt aaacgcatca 1773181 agcttagagc gcatgccgcc ggtgccaacg atgcttccag tgtcacctgc gcatgcttcg 1773241 atgtcaggtg ttatttcact cacccgctgt atctttttcg cttctggatt tgtgcgcgga 1773301 ttgccgtcat ataatccgtc tatatctgat aaaatcacaa gcatatctgc atcaatcaat 1773361 cctgcgactt ttgctgcgag cgtatcattg tcgccaaact tgagccgatt gacggtaact 1773421 gtgtcatttt cgtttatgat cgggatgatg ccgcgctcga gcagtacatt cattgtattc 1773481 ctgacattgt tgtatcgata ttcatcagaa aaatcgcttc tcgtaattaa aatttgggat 1773541 gcgacatagc cgtgtgccaa aaacagcttt gaataagcct ccattagcaa tccctggccg 1773601 attgaagctg atgcttgttt ttctggaagc ttctcgggcc tttggataaa tccgagcttc 1773661 cgatatcccg ccgccactgc gcctgaggaa accaaaatca cttcataacc ggcgtctttg 1773721 agtttgacga cctggtcgac caacgcttct aattttcgaa tgctgatttc tccatgaagg 1773781 cttgttaatg aactgcttcc aatcttcaca acgactcttt tcatgcttgt atcaggcgtc 1773841 actttatcac tcctgatagc ggcgctgcag ttttttcgat atcttcgctg atttcctttg 1773901 aacgcttagc cgcatgcttt attgcttgag aaatcgcttc tccgccgccg ctctttttca 1773961 aggcttgcag ccccgctgct gtcgttccgt tcggtgacgt gatattatct cttaagatct 1774021 caggatgttc tcctgtttcc atgagcattt ttgcggcacc taaaagtgtc tgtgcgccga 1774081 tgcttcgaga taactgttta tcgaggcccg cttcctcgcc tgtcttttca atgaattcca 1774141 ttaaataata aaaatacgcg ggtccgctgc ctgcaattcc ggtgaatata tccatttgat 1774201 tttcttggat tgtatagact tcgcccatgc atccgagcaa tgcttcggcc agcttcttca 1774261 ggtcttccga cacatatttg ccaagggcaa tagctgttgc agaagcgcca atcatactgg 1774321 aagtgttggg catcactctg acaaccggct gttcattaag caatgattgt tcaataaaag 1774381 aggtagttat gccggcaagg accgacaata ttaattgatg gggttgaata cgtgatttta 1774441 gtgatgacag agcgttttcg gcgtcttttg gcttcattgc caaaatgagc acatccatgt 1774501 cttcaataca tagttggttc ggcaaggcgc ctttaatgcc atattgaagt tcaagttcag 1774561 ttaatcgctc tgtattgctg cggtttgtaa cgcagatgtt ttgtttcggg attttgttgg 1774621 ctcgaacgat acctgatatc attccttccg ccatagatcc tgctcctata aaggctactt 1774681 tcttttgatc aaagatcggt aacatctcct ttgttcgctt ttttgttcgc attttcacac 1774741 gtttaaaatg ttaccacgtg aggaaatgat gtcaagtttg aaggccatta ttgatttgta 1774801 ttgtttcttt tcgacaaata tgtataatga aaagcagaaa acacccggtt cacactgctg 1774861 cgccgggtgt ttgtttctat taaaaattat ctgagagagc tttttcaatc agttttttac 1774921 agcgatccag ctctaccttc agctgttttt tatatagctt ggcagcttcg taatctttaa 1774981 attgatagag gacgacttcc tggagcttag ccccttcttt ttttacttta atttgtttta 1775041 gtatcccgtc atcaagaagc tcatgcaaag accggtatac ttctgtatga tttggtttaa 1775101 aaccaatctc tttaaattca gaccgaagta cttcaagcag ctttaaccca tagagtctct 1775161 cttgctctgt catcgttatc atataaagct tcaaaaatgc gcgctgtttc actaaaaagc 1775221 ctgttgaact ccttttttct tctttcatca tatgcactcc ttcttctgtc actgacaaca 1775281 ctatgtacta aatattcaat tttcttttat tgttttcctt ctttatatta aagactgata 1775341 gtccagttat ttcatgttta ctgattatag gtgtagcgga aaaaataaat ttcgactgaa 1775401 catttggtac atagttttct tagttctatt atagcctgca tttactgcta tcttcaattt 1775461 aaacgattgc cagggtttac atatctcatt ttaccggtac ggatttcatt caaataaaaa 1775521 aacctgtcga aagacaggtt ttcattttta aggatttgtt gaccataatc ccgctgtttt 1775581 gatgaaaata cgaggatcta atttcagttg tgccaccatg tactcagcaa gatcctcagg 1775641 ctgcataact ttttcaggat taccgtctgt taagttcaat tcgatagaca tatcactagc 1775701 gacagtgctc ggcgttaacg cgctgactct gatattatgt tttctcactt cttgcataag 1775761 agactctgtt aacccgagaa cggcaaattt agaagcgctg taagcacttg ttacagcagc 1775821 tcctctttgg cccgctgtag atgaaatatt aatgatgtct ccggctttgc gttcgatcat 1775881 ttccggaagc accgcgcgag tgacatggta cacacccatt aggttgactt gaataatatt 1775941 ttcccactca tcagctgaca gatctaagaa accgccaaat ttgctgatgc cggcattatt 1776001 aatgaggata tcgatatcac cgagctgttc cttcacttga gctacagctt ggttaacctg 1776061 atcggcatct tttacatctg cagcagcaaa tgcagctttt acaccaagcg ctttgacttc 1776121 ttcagccact ttttctacat tagcggaagt ccggccaatt aacccgatat tcacgccttc 1776181 tttggcaagc gccagagcag tagcgcggcc aattcctctg cctccgcctg tgattagtgc 1776241 agttttatgt tgtaaacttt gcaattgaag caccctttct ttgtttacat atgtacgata 1776301 tcacattata agtacaatac atccaatacg caaatcaaac gaactgtgta aatatcattt 1776361 cttctgatta aaaaaacgga tacagggtaa tgacataaga aaaggagtga acatatgatt 1776421 atagtttata tcagtcttgc agtattagca gtttctatta tcttcttagg agttaccgtg 1776481 atccaaaaca agaaaaaaat agaccccgca ctaaaggagc tttcctctgt tacgcaggct 1776541 atgcaaaaac aaatcgaagg attaaaaaca gaaacagagc tgctgacgca aaaacaaaag 1776601 aagattcagc aggatgtcca aataaaaaaa tacacgcttc agcagaccgc agctgaagtg 1776661 aaagaagttc cccaagcagt caaagaggtg tggcaggcag gacattttaa tagcagataa 1776721 ggatgaatga gatcccgttg ttacgatcag aatggacaaa tgggatctca tttttcgagg 1776781 aggcttacac atgattataa accgcagctg cttaaaagag ttcgcagaaa aagtacattt 1776841 tcttccctct tcacttacaa agtccgattt acttactgat ccatttcgtc tccatcaaga 1776901 aaacgaactt ggcatctact attcacctca taatgaattt atcaatcggg atgcctcgct 1776961 tgtgattgcc gggatcacgc ctggtttttc ccagatgaag acagcgtacg aaacagccgc 1777021 cgaaagcctg ctgcaaggcg ggactcttga gcaaatggca gtagacacaa aaatagcagc 1777081 gggtttctcc ggatcgatga gacataacct tattaccatg ctggatttat gcgggctgcc 1777141 gcaagctttt ggcattcaaa gcgccgcaaa gctttttgga gaattacggc atatgctcca 1777201 tacaacttcc gttattaaat atcctgtctt tatccagcaa aaaaactata ccggatacaa 1777261 accggctatc actcattctc ctatcctaag cacttatgct tttgggcact tccctgcaga 1777321 gcttaaccat gtgacgggac cagctcttct cattccgtta ggaaaagcgg ccgaaacagt 1777381 gtgtgaaaca ttgatcagac agcacagcct ccagaatttg atttgcctta acggctttcc 1777441 ccatccatca ggcgcgaacg gccatcgttt gaaacaattc agcaaaaaca aagagcaact 1777501 agaaagacaa attcgttcct ttgctgcatt ggttgatttc gctatagaaa agaggaaata 1777561 aaagggatat gataaacaaa aacacaaacg tggggagtgg ttgaatgttt cctatattag 1777621 aaacggatcg gcttatactt aggcaaatca cagatcagga tgcggaagcc atttttgctt 1777681 gtttctcaaa cgatgaggtg acacgctatt atgggcttga aaacatggaa tctatagaac 1777741 aggccatttc aatgattcaa acgtttgctg ccctctatca agaaaaacgc ggtatacggt 1777801 ggggaattga aagacgggac actaaagaac tgatcggaac aattggcttt cacgctctgg 1777861 cccaaaagca taggcgcgcg gaaatcggtt atgaaatcat cccggagcat tggcgaaacg 1777921 gatttgcatc agaagtcatt tcaaaggtcg tatcttacgg attttctgcc cttggactgt 1777981 cgcgtattgg cgcagttgta tttaccgata atgaagcatc aaatcgtctg cttctaaaaa 1778041 tggggtttca aaaagaaggc gttttaagac agtacatgta tcaaaatggg actccatatg 1778101 atacaaatgt gtactctatt gtgaaaccaa gagaatgacg gtattctctt ggtctgtgcc 1778161 acatcccttt tcctttaaaa agataaaaag cgcccctcaa acagggcgct ttctaattaa 1778221 gatgcatatt gaggagatgt ttcctcctta actgcttttt cctcaggtat atgaatacat 1778281 tttgtcaaga ccgcacttgc aaggtaaagg gccgcaaaga tccagacgac accttgcgcg 1778341 ccgacgagac cgatgaacag ccaagcgagt gcagggccga caaacgctga taaacctgca 1778401 gctaaattca atacagacat ggctgcccct ttatcttttc ctgccaccgt cggcacaatt 1778461 gcaccaatcg gcacatagcc tgccagcaaa ccgccccaaa taaagccgat cacgctgaca 1778521 accgctaaac ttccgccgga gaaaacaggt gcgtagtata ataagacggt gaaaatgccg 1778581 cagccgactc cgccgaacca aataacagta tttttccagc cgaatttatc gccgacaata 1778641 ccgaagataa ggttaaacac aatgttcccc aggaaaatcg ttccccaaat ttgcagccac 1778701 acattggttg aaattccatg ctgggccatg tgcatcggca aaaagactgg aaaaccatat 1778761 gtaccaatgc tgttgatgat tctgatgatt ccgcctgtaa gcacgcgcgg atttgtaaat 1778821 agaatcgtaa ccccttttaa aagctcctcg gctgtttctg atctttttct tttcttcttt 1778881 tcaaaacggt ctttattgat aaacaatgca aagaatgcac cgagacatac ccagaaaata 1778941 gagctccaaa gcgtattcaa ataaccgaac gctttgatcg cgtagcttga gtaccaagcg 1779001 ccgaacacaa acatgccgag gcaatatgca atccaaaacc agccgacagc agtgctcagt 1779061 ttgctttgcg gtgttctgta aatgacccat gtcaagaaag aataagcaaa aagcgggtaa 1779121 cctaaccctt ttacgaagta agtcacatac atcactggca ggttcagctg ttcaaatcca 1779181 aatacgataa aagcagctgt accgatcaca taaaacaaca gccccataaa catcgttcgt 1779241 tttgcgccaa atgcttcgag acatacaccc gaaaaccagg aagctatggc aagcgcaatt 1779301 ccgtatatac taaaaatgga agcggactgc tgaacggtga gcccgttttc gatcaaaaaa 1779361 ggactgagcc agccttgttc aaggccatct cccatcataa acaaaacaac ccctaaaaat 1779421 ccccaggcaa gccgcttcgg tattcctatt ttatccaaca tatctgtctc ctccttagat 1779481 gctattattc attaccgtat taccttatta aagttgaaaa ttaaatgatt cctcaaaaca 1779541 gcagaaattc cgtcttaaat taatactttg ctttctgatc ctgaaaaaaa gcgctgtgtt 1779601 tgcttccatt cctcatataa agccaattct atctgacagt ccttcggttc gatcacccgg 1779661 acatttgctg acatctcctc cgttaattga aaggtttcat tgcaaatgac tgcagcaccg 1779721 acgacagatg cctgatgata tccctcttgg acatagacct ttttttgaag aagatccgcg 1779781 atatattgag tgagcgcttt gctttggaat ccccctccgc acacccaaac ataatcacgt 1779841 tcaaacggag taacctctgt taaaatgtca aagttccatt tgattgaaaa tgcgatctct 1779901 tctagcgctg cacgtacaaa atgtgccctc tttaaatgtg ctgacagcgg ggcatcaaaa 1779961 agaaaaccgc ctctcgttaa cgcattcttt tcagccgata aataagagcc gagagccgct 1780021 acacatgcat ggtcttcttt tgcaagtgca gaaatctcct cctccattac ttcgtacgtt 1780081 tcattcggat aaaaaatctg ttttaatttt tgataattca agccggtaat tcccggattc 1780141 gtttccacaa gccaatgccc ttgatccgta tgacagttca accaggcttt atgttttgtg 1780201 tcgccatgat cctcagtaat tttggttatt ggcgttgttg tccctgatac aatgacaatg 1780261 tcctcaagtc cagctccggt gcttttgaca gccagctgtg tatccccgcc ccctgctata 1780321 accttagcat ttattgaaag gcctaattcg gatgcatatt catttgctat cgttccaatt 1780381 gctgttcccg ctcttacaag aggcggaagg atagatggag aaaagccgaa aatgtcgcac 1780441 atctcttctg accaagtgtt ttgcttcaca tcaaatagca gggtttctgt tgcctgtgat 1780501 ggttcatatg ttaatattcc gctcagttgg tacgtcaccc aatcactgat gcttgtaaag 1780561 cttgcagtct tttcccataa agagggctgg cgctgtttta atccataaag cttgagcgca 1780621 gaaaaaagtg cagttggcag gcggcctgtg ctgctgtata tctcttccca atcgggaatg 1780681 cccgcctccc actctcggcc gcgattatcg atgttcggca gcccgagaaa aggattgccg 1780741 ttttgatcaa tcaaaacaat cccctgtctt tggctcgtcg atgtcaaacc aatgatgtca 1780801 atatcacacg aacgggatag cgcacgtttt gccaaattca tcacctgctt ccacagcacc 1780861 tgaggagaaa aataacggct gtccgggtaa agcgtctctg tggaatactc gatgtcctcc 1780921 cgttcaactg ttagaacact gccagttaca ctcacgaccg ctaccctcgc attgcctgtg 1780981 ccaatatcaa aaacgagata gcctttttgt tttttcattc tgttagcctc ctttcttatc 1781041 cccctgtttt cagtgcgtcc ttgttataca ttgtctgaat attaagagtt ttttcaccct 1781101 tccacttttt gagggcttta ttcagtatcg tcacgtgatg atcctccact tcaaatgttg 1781161 ctccagcgag atgcggtgtt gccagaacat taggcaatga aatcaattca taatctgatt 1781221 cctctggagg ttcatgataa aaaacgtcta gtatcgcacc gctgatttta tgttctttta 1781281 atacaaataa aagatcttca cggtttacaa caactgctct tgaagtatta acgaaaatcg 1781341 cactctcttt catcagatca aaatattgcc gatctatcag tccgagtgtt tcctcagtgc 1781401 gaggcagatg gacagaaacg atatcgctgt ctgaaaacac cgttttaaga gatgcttttt 1781461 catacaacgg atgatcgtct tgaatgtatg gatcgtaata ttttatctta cagtcaaacg 1781521 cagtcagcag ttttgcaatc ctttgcccga ctgcgccgaa cccaatcatg ccaaccgttt 1781581 ttcctgttag ctcatttcct ttaaatttga cataagcctg caggtaatca ctgtcccact 1781641 ctccatcctt cagccactga ttcgaggcgc tggtatggcg cagaaaggaa atcacatttc 1781701 caataaacat ttcggcaacg gcttgtgcat tccgccctgg tgtataaaaa acaggtatgc 1781761 ccctttttga ggcagctgcc acatccacat ttgagggcat tcccctgcaa acaccgacaa 1781821 atgaaagttc gggaacagaa gcaaatacgc tgtctgttac ctgatcaagt tcagtaatca 1781881 agcctgtcgc atttgttgct tttagcagct gaatgagttc atcctcccga tatgccctac 1781941 cttgttcctt ccaagattga taagcaactg agccaaacaa gttttcaagc tcttttcgtc 1782001 cttcttcgtt gtacggtgct gtaaccaaaa ccgtcatgct gcaaaacatc cttttcatcg 1782061 tatttttcat aaaaaaaatc tctttccgaa gatggaaaga gattcatata taggcgcgct 1782121 ctgttacagg cagacgccgg tataaacctt gctttcctat ctttcaagct agcgcttgct 1782181 ggaattggca caataatgtt gccgaggttt catagggcca gtccctccac ctctctggat 1782241 agaaaatatt gagtatgtaa ttttcagaat gaagaatacg tttatcataa agaagactca 1782301 gattgatgtc aatctctttt tttcagaatt gacgttatca tcggaaatgt tataattctt 1782361 acaaaatatc taactagaga gaggaactgg gccatgagat cttttgccac acaacaaaac 1782421 ggcattttca aatccgtttg ctcgctggac tgcccggatc agtgcggatt gttaatacat 1782481 aaaaaagacg ggaaaatcgt aaaagtgcaa ggagaccctg atcatcctgt cacagctgga 1782541 aacatatgca acaaagtccg gaatatgacg gagcgcatct atgatgaaaa gcggctgact 1782601 acaccgctca aacgaacagg tgcgaaaggc caagcgatat ttgaaccgat ttcctggaaa 1782661 gaggcaatcg atacgatcac ctcccgctgg aaacagctga ttgatgaaga gggagctgaa 1782721 agcatacttc cttacagctt ttacggaaat atggggaaat tgacagctga aggaatggac 1782781 cgccgctttt tttaccgcat ggggtcaagc cagcttgaac ggacgatttg cagcaaagcg 1782841 ggatctgaag gctataaata tacaatgggc ataagcgcgg gaatcgatcc tgaggaaacc 1782901 gttcatacaa aactatttat tttttgggga atcaacgcgg tcagcacaaa tatgcaccaa 1782961 attacgatcg cccaaaaagc gcgaaaaaaa ggtgccaaaa ttgtcgtgat cgatgtgcat 1783021 aaaaatcaaa caggacgtct tgcagattgg tttatcccaa taaaaccggg aaccgacagt 1783081 gcacttgctc ttggcatcat gcacatttta tttaaagaaa accttcatga tgaagcattt 1783141 ctgtccgagt acacggttgg ctatgaagag ctccgtgaac acgtgaaaca atatgatcct 1783201 gaaaaggtat cgacgatcac cggtgtcagt accgaagata tttaccgact ggcaaaaatg 1783261 tacggggaaa cctccccttc ttttatcaga atcggaaacg gaccccagca tcacgataac 1783321 ggggggatga ttgtaaggac gattgcctgt cttccggcga tcaccggcca atggctgcac 1783381 acagggggcg gcgcaattaa gcataacagc ggaattttag aatataacac aaatgccttg 1783441 cagcggcccg acttattgaa agggcgcacc ccgaggtcgt ttaatatgaa tcagcttggc 1783501 agggtgcttt tggaaacaga cccgccgatt cgctctctat ttatttacgg aacgaaccct 1783561 gccgtcgtcg cgcccgaagc aaacaaagtc agacagggct tgctgcggga agacttgttt 1783621 actgtggttc atgatttgtt tttaacggaa acggctgcat atgcggacat tgtactgcct 1783681 gcaacatccg cttttgaaaa tactgatttt tacacctcct actggcacca ttacattcag 1783741 cttcagcagc cggtgattga gagatatggg gaaagcaagt ctaacactga ggttttccga 1783801 ttactggctg aagccatggg attcacagac caggagctta aagattcaga tgaagtatta 1783861 atccgccagg cgcttgacca tccagataat ccgcatttgg cagagattga ttacgattca 1783921 cttactaagc attcatttat gaaagcgaaa cgtgaaaagc cgctgtttcc gggcgaactt 1783981 ccaacgccaa gcggaaaaat agaattatat tcagaaaaaa tgaaacaaga cggcttccct 1784041 gctttaccga catatacacc tcttgtaacc gataatgaac atccgtttat gtatgttccg 1784101 gggccaaacc ataatttctt aaactcaaca ttttccaata atgaaaaaca catcaagctt 1784161 gaaaagacgc caaagctctt tatcaacaca aaagatgctg aaaaacacgg aatcgttgat 1784221 ggggcacctg tacgaatttg gaacagccgg ggagaatgcg agctgaccgc tgcagttgga 1784281 gaacaagtgc tgccaggtgt cgttgtcagc caaggattat gggcggatga acaaggaaaa 1784341 aaacagcttg taaacgcgct aaccccagat cgcttgtccg atatgggcgg cggcgccacc 1784401 tttttttcag gccgtgtaca gattgaaaag gtttgaaaaa taatgaaacc cggagtatgc 1784461 caagcccgta taacataaca tcgacataat ggaggcatac acatggacgt ttttttagga 1784521 attggtattg ctttggctgg atattttatc ggtgaaggct taaagcagag gaaccaaacc 1784581 aaaggtaatg aacaaaatga tatcttccta ataaaagaac gggatattta cttttacatt 1784641 ggactttttt taggaataac aacgactgaa gcaaaacagt tagctggaga catggcagac 1784701 ctgccttaca tcgaaataaa cggaaaaaaa tatgtccaga aacatatgtt aaaagattgg 1784761 acattcacat tagttgaaaa acatcagggt gaataaaaca aatctgagga gagcgagatt 1784821 cattgtcacg ctctcctctg tttagctgta tggatcctgc caccaaaact ttgtgctata 1784881 agcgctgata aaacgataaa ccaccatcta tgttctttcc tcaaacaact caagatgccc 1784941 gttccacaac aatagttttt atattccttt gatgacgtga tgttcttgat gaacgtatgt 1785001 atcgtaaaac acttagaaaa cctattcggt ttgaatgtgt gctctcatta tgcccccata 1785061 ctgcgccttt atccgcggag gattttttta aaaaaatatg aaacctaaag cttttagatc 1785121 ctgaattttt attgaacctc catatttctc cgattggtaa aaattagcct atacaccgga 1785181 agctgtacgt ttataaagga tcagagaatc ccataaccag taaatcactg cagccgcaat 1785241 acttaacata taataaaagt acgattgcaa tgtccatgct attgacgcag gttcattgat 1785301 aacaaaaaac aggaaagctg cgataaaagc aaccacactg taaatcaata ggtacatgac 1785361 attgaaagtt ctcgcttttt tctgcaactt catttggagc ggaacagcaa aaaggccata 1785421 caccacaaaa ccgtataata aagcaattgc tgccgtaaac aatgcaatta tcatatcgcc 1785481 atacataacg aaagaataaa accctaataa caaaccaaat gtaaggctgg atagccctaa 1785541 tgtcattaaa taatatgatg cgattttttt cattttttca ccccccttgt ttgatttatt 1785601 cacagtgctg ttagtataaa ttcacaacct ttgtatttct tttatcgaga tgtcttccct 1785661 aacgtgctat acgcaatgcg ctaataaaag gtttcaaaaa tgacgttctt ttattagata 1785721 atacgctggc tgaaaacgcc tctcctgatt ggccaaagcg cgaatgaaaa aagtgcatga 1785781 atacctgccc aacagacaga ataagaagag ttgatatttc aacacttttc gtaaaggggt 1785841 gaaaccaatg agtaagaaag gtattcaaaa ttcaagtatt gaacaaataa gaaatgacca 1785901 tgagactgaa acagctttta aagcagatga tcctaaaaaa cacggttccg atcctaaaag 1785961 aacgaaataa gttcttaccc ccactaaaat atcaataatc tggaggaagt aaagtgactc 1786021 aaaaaaacgg tgcagacaga cctgatgatt ataaaagatt ttcttcatta gacaaggaat 1786081 atgattttca gcaatctata cgcagcaata ctgagacaga aagtgtaaac actgaaacac 1786141 aaactcataa caaagaaaac aaaaatgaca caacagatgt tgccgggaaa tactttgagc 1786201 cctcagatta taaaggaagc acgcaattag aaaaaggatt ggctgaaact catgaacagg 1786261 tcagcgatga ctattttgaa gggacaatcg atcaaaattt ggactagcca tacaaacgga 1786321 actaacttaa aagaagtcag ttaactctgt ttttagaaac aaccacagta aaagtagcca 1786381 acccccaccg aataagatgg gggttgcacg taagtagcct gtttaatatt taaaacgatt 1786441 aatgacggtt tgaagttctt ctgccaactg agatagagat tctgcggcat aggagatttc 1786501 ccccattgaa tgaagctgtt cctgtgatga atttgcaacc gcttctgtat ttgctgacgt 1786561 ttcttttgta ccagcagcca atgtatgaac tgtgtgctga atcacttcaa cgcctgaagt 1786621 aagctgttga gttgctgctg caacttcttg tatttgagaa gtgacctgtt ccaccaggtt 1786681 cagtatttca ttgaaatttc ctgttgtctc ttgagaaaga acaatacctg agctcacatt 1786741 ttcttgaaca actttaatat tatttaccgt ttctatcgat tcgttttgga tggtcgctac 1786801 caccgattgg atgtggtttg cagatttatt tgtttcatcc gccaacttcc gaacttcttc 1786861 tgccaccaca gcaaatcctt ttccttgctc tccggctctg gccgcctcga tcgctgcatt 1786921 tagtgccaac aaatttgtct gctctgaaat cgtcgtgata agcgaagaga tatcgctgat 1786981 ttctgctgtg ctcgctacca atgtttgcaa tccattgccg gctgaatcta cagatttatc 1787041 aatgaatttc atctggtcta acatcttgtt gacggactta gagcctattt cagccttgtc 1787101 tctcatcgaa gaagaaagat ccgctatgtt ccctgtattt gaagcgactg atgatatact 1787161 gtctaataat tcagtgatgg attctgcgct cttttctgtc attgagcttt gcttcacatt 1787221 gctgtcggca gccatctgca tggctcgtga aatatgttca gatgttgatt tcgattcttc 1787281 cgcgcttgcc gataattctt cagaggaagc ggcgacttgt tcagatgagc tgctgatctg 1787341 cttcacaatt tgagttaatg aatgagtaaa agaattaaaa gattgggcaa gctggccaaa 1787401 ttcatcttta tttttcacaa tgactttttt ggttaaatca gcctcgccgt gtgcaatttc 1787461 ctccagctgc ttatttatgc ttcttagtgg caccataatg gactttaaca gcattatgct 1787521 tagaacaatg cctaatatta ctgatatccc tgtgacaatg ataatgagcg attgactcat 1787581 tttcccattg ccctgtattt catcctttag atcctctacc tcttgatcca ggcgatcaga 1787641 cagcttattg acagccggag ctacgccttc ttttcttatt gttctttctt ctccaaaatg 1787701 gatggtttct gcttttttag gatttgaaga gtaggctgtt actacttgct gattcaaagc 1787761 tctatactga gtaaaacttg tcttaatgtc ttcaatattg gattgatact tctcttcatc 1787821 aatcaagtca ttaacccggt caaggctctt taagacatcg tctgcttttc ccttcatacc 1787881 ctcgtcgtat tctttgtctc tggtaatcaa gaagcctctt tcatcatttg ataacccggt 1787941 caattcatat tggatgtgtt ttatctcttt ttggaattcc attttgtctt taagttcttc 1788001 attctttttc acagtagaag aaatcataaa tactgaggag cctccaattc caataattga 1788061 aacaactaat attgatataa tccccagcaa ttttgttttc actttcatgt gtcgttttcc 1788121 ctttccgcac aatgtaatgg ctgaaataaa atatgttcaa gcgcgtttga atccaattcg 1788181 cttacgctca tgtccataat atcgacacgt gttatcaagt tttatagtga tattcttata 1788241 tgaataagca aattctttac gtctctgaac ttacagaaaa accttaagta aaatttgcag 1788301 tcttttgcgg tatgtaagtc actcttattc gtttttctaa aaaaggcttt tcccacctca 1788361 aattggctga accggctgtt ttctcgaaaa tataatacaa tacgcagcat aatatgaagg 1788421 agcgaaactt aaatggggat catcaatggt aaagaattca ttgaccgatt gaataaacta 1788481 gaaaacgaaa tatggtatga tggcgaaaaa ataaagggta acatttctga gcatcctgca 1788541 tttaaaggaa taatcaaaac aaaaagctca ctttatgaat tgcaaacaaa ggatgagtta 1788601 atacatgaaa tgacttattg ccttcctgga gatcataatc gaatcggcct ttcctatctc 1788661 cagcctaaaa caaaaaatga tttgaaaaaa agaaggacca tgattgaaca ttgggctaga 1788721 catactcatg gaatgatggg gagaagtccg gattacatga atacggttat gatgagcttt 1788781 gcttcgtcag cggagcttct aaaagataaa gagaattgct ttcctgaaca tatactagat 1788841 atgtatgaac aagctgctaa gcatgacctt tcctttaccc atacattcat tactccgcaa 1788901 gtgaaccggt cacagtccta ttttgggcta agtgaaaaac cgatatctgc taaagtcatt 1788961 gatagaaccg aaaaaggttt aatgattcat ggcgcacgac tgcttgccac acaaggcggg 1789021 ttgaccgatg aaatcttggt tttttcagcg cctaaatttt tctttgaaac agatgaagct 1789081 tatgcttttt caatcccttc taatacaaaa ggcgtaaaat tcatcacaag agaatcattt 1789141 gtattaagcg actcttcctt taatcatccc ttaagctcaa ggtatgaaga aatggattca 1789201 attgtggttt ttgatcatgt gttagtgccg tggaatcgtg tgttttttta cgataatgtg 1789261 gaagcagcta aagattttat gacaaaaagc tcttttcatg cctttacctt tcaccaggtt 1789321 gtcattaggc aaatgataaa aattgaattt ctattaggtg ttgcacagct tcttgtcgac 1789381 accattaatg tttccgaata tcagcacatc caagaaaagc tctcagaaat cattgtggga 1789441 ttggaaacaa tcaaagccct cattgacaaa tcggaaaatg atgctcagtt agatgaattc 1789501 ggctatatgc gcccctgttt aattcctctt caagtcatca gtacgatcat tcctaagcta 1789561 tatcctcgat ttactgaaat catacaatta attggagcta gcggaatggt gacactgcct 1789621 accgaaaatg catttgactc agagatacgg gaagatcttg accaatatct tcaagcaacc 1789681 aatacaaatg ctgaagaacg tgtgaaaatt ttccgtttgg catgggattt aacaatgagt 1789741 tcattcggaa ctagacaaac tcactacgaa agatattttt tcggagatcc tattcggatt 1789801 tcaagcaggc tgtataccag ttatccaaag caggagcagt tgaacatgat taaaacattt 1789861 ttacatgcag atacagaaca ttgaaaaaac agcgggaaaa gatccgctgt ttcgtatttt 1789921 ttattcagga aactgaacat ggcccggtac tgtataggct ttggacgttc cgctttcagg 1789981 cagctttgga atggtgtctt tcacaacttt tccgcggatg tcagtcattc tgactttgag 1790041 agagccagta cctaaattcg tactcacaaa atggttatag tccattttct ccatgttgat 1790101 ccacttacca tccttttcat attccatttt cataacagga tacttgtgat ttctgacttg 1790161 gattgctgcc caccacctgc tgctgccttc tttgatccgg tacgtgaaat tgccggtgat 1790221 tggggctttg acaacacgcc atttaatatt gatttttccg tctttcatat tgccgatttt 1790281 acggaaggca ttaggtgaca gatcaagagc tccccgagcg ccttcgggat aaagatcagt 1790341 aacatatacg gttgttttcc cttttggccc ttcaacttcc aaataagagc cggcaagtgc 1790401 cgcttttact cctccgtaat tgagatccgc cggatttatt gcagtaatct ccatatcgga 1790461 aggaatggga tccagcagga aagctcctcc tgaatagcct gaccctgtat acgttgcata 1790521 accttcatgc aggtcgtcat atgctgccga agcttgcggg gaaaaacaga agatcgtcaa 1790581 caaaaccata ccaacaaatg cactcatgat ctttttcata tttggtcctc ctcaaaccag 1790641 acttcaaatg agaatcatta tcattataag actcaatcca tctggtttga aagaggaaat 1790701 agattcatag ttgattttaa ggcaaattca ctatcattca tatatcaaat gtaggtactt 1790761 atgaaaaagc caatacaaat gaacgaatgt gcacttcagc cgaatgtctt atttttccct 1790821 ctcaaaattc gcatttcaat aacgaaatga aacaggctgt tggcctgata acagctatac 1790881 aggaaaagct atttttcccc gctcagtttc aacttagctg tcatcatgat gccaaagatc 1790941 agcacaatcg gaacccaaat aatgaagtga taaaaatcag gctcagccag agcaacaata 1791001 atagccccta cacaatacaa aataatagcc agtgctctta acacagtatc tcttaagaaa 1791061 gtcttctttt gcttcttaaa aaacaaacgg ccggatatat cctctaaaag agaagccaaa 1791121 gtgccggtca acacagttga agaaatacct gcaatcccca gtttttttgc tgctgtagtt 1791181 tgaatcccca tagaaatgct catgagtata attagaatgt gcacaggaac aaatgcccgg 1791241 taaaaagaaa gacaagcaaa gacaaacaaa atgaatgctt caagtgcgag ggcttttgtc 1791301 acagcagaag gccaaagggt attttccgcc tttccgacca tcaatgtagc aatgatcacg 1791361 ccgcatataa atccgattag cgcagtcaag gaattaaaaa cagtgacctg aatggatttg 1791421 ccgatagcta accccaataa tacaatgttt ccagtcatat tagctgtgaa cacatgtccc 1791481 aggcttaaat acccgattac atccacgatt ccagctgtta aacataaaag tgatagcaag 1791541 gtgtttcgat aagctgctgc agtcaacggt gtatcaatcc tttcttctat ttcaattgtt 1791601 agtatgtctt ttggcgcaat ctctattttt taagtaaccc aacattaatt aggaagatag 1791661 aacctattat tcctttccat taactgtaat aataatcccc gcaaggaaat gattaaaatt 1791721 gaaaggaagc atattgtgat gaaacgactt tgtttatggt tcaccgtctt tagcttgttt 1791781 ttggttctct tgcctggaaa agcattaggt gcagtcgatt ttccgaatac ctcaacaaat 1791841 ggccttttag gttttgccgg aaatgccaaa aatgaaaaag gcatctctaa aacgggcaca 1791901 acgggtggaa aaaacgggca gattgtttac attcaaagcg taaatgattt aaaaacccat 1791961 ctaggaggat ccactccgaa aattttagtg cttcaaaatg atctttccgc atctgcgaaa 1792021 acaacagtta ccattggctc aaataaaaca ctcgtgggct cttacgcgaa aaaaacgctg 1792081 aaaaatattt atttaacaac ttcatcagct tttggaaatg tcatttttca aaatttaacg 1792141 tttgaacaca gtccgcagat taacggaaat aatgatatcc agctttattt agattccggt 1792201 atgaactatt ggattgatca cgtcacattc tcaggtcata gctataatgc aagcggaagc 1792261 gatttggaca aactcgtgta tatcggaaaa tccgcagatt atatcacgat cagcaactca 1792321 aaatttgcga atcataaata cggtttgatt ttaggatacc cggatgattc tcagcatcaa 1792381 tatgacggct acccccacat gacaatcgcc aataattatt ttgagaactt gtatgttaga 1792441 ggcccaggtc tgatgagata cggttacttt catgttaaaa acaattacag caataatttt 1792501 aaccaggcga ttacaattgc tacaaaagca aaaatatatt ccgaatataa ttactttggg 1792561 aaaggcagtg aaaaaggcgg catccttgac gacaagggca ctggttattt caaagacata 1792621 ggcagctatc catcactcaa caagcaaacc tctccgctga cttcttggaa tcctgggtca 1792681 aactatagct atcgtgtcca aacgccggaa tatacaaaag aatttgtcac gaaatatgcc 1792741 ggatcacaaa gtacaactct ggtatttggc tactgatata aaagaggccc tgcgttaaaa 1792801 acgctgtgcc tctttttata ctataggcta tttttaagcg atccttgtaa ttccatcaag 1792861 atccagcgtc ggtcaaacta aaaagcatat gttcttttcc acaataactt cttaactggc 1792921 tttcttatta taccagttta tcgcaagtga aaagaaatca ttgttctgaa cctgtattaa 1792981 atgaacgatc gtcccacaaa ctacttaaaa acccctaaaa aggatgatgg atatgtgcgg 1793041 caggtttact ttgtactctg catttgatga tattattgac cagtttgaca tcgatcaatt 1793101 ttttcctaaa ggtgaatacc agccaagcta taatgtcgca ccatcacaaa acatccttgc 1793161 aatcatcaat gatggatcaa ataatcgctt aggcaagctt agatggggac ttattccacc 1793221 ttgggcaaaa gatgaaaaga tcggttataa aatgatcaat gctcgagccg aaacaattac 1793281 cgagaaaccg gcctttcgaa gaccgcttgt cagcaaacgc tgcatcatac cagcagacag 1793341 tttttatgaa tggaaacggc ttgattccaa aaccaaaatc ccaatgcgga tcaaattgaa 1793401 atcatctgct ctttttgcgt ttgctggctt atatgaaaag tggagcacac atcaaggata 1793461 ccctctttat acctgcacca tcataacaac tgagcctaat gagttcatga aagatataca 1793521 cgaccgaatg ccggttatat tggcccatga tcatgaaaag gagtggctta accccaaaaa 1793581 tacaagccct gattatctgc aaagtttgct gctgccttat gatgctgatg acatggaagc 1793641 ataccaggtt tcatcattag taaattcacc caaaaataat tcagctgagc ttcttgatgc 1793701 agaaaatcat atgtagtgat tgaaaaaatt ctctagcaag aacttgtcaa atagctttgt 1793761 tccttaggtg ccaatccctc tagtaattat gaatatttag tacatagatc aattagttat 1793821 ctttagcatc agtttgaaat aattttatta tgtaaactta aataagcaat gttattcctt 1793881 tcatataaaa tagtttacat ttttataaaa tcgcttcact tttctatttt gtcagcaaaa 1793941 aaactgaacc acattaaact tatgaaacct gccgcacctg tggattgcaa atatgatata 1794001 agcccataga ggtaaatcca tacactttcc ctcctaagaa ttaaatgaaa tttctttcat 1794061 cttacatgaa ggtcttcttt cttttgttta tccagtgtaa tacttaataa tatgttgatg 1794121 aatgcagctg gaaaatatat aaatcccact ccaagaatgc ctagtatcgt acttaaactt 1794181 actatgtaat tctttgtcat cgtttgactg tcaatcaata ttagaagtga aatcaatcca 1794241 gctaaaacac ctataaacca agcatcgcca acagcataag aatcatccag catccctaac 1794301 catcgcccca atatagagct cccaatggca gtcaaactgg ataaaaatat gagtgctttc 1794361 atttcttctc ctcctttaaa gccaatcaaa ctggtagaaa tcggccattg aatccccatt 1794421 atcgaatggt taccatttca tttccacatt aacattttaa agctcattac aatacgattc 1794481 aagcagaaaa accctacata acgtatatat agggatttaa taaaacacag gccaaaattc 1794541 agctctatct actttaaaaa gatatgaagg gcagctgtgt gatctgttac gtctttacgt 1794601 accgggatat ttcacaacag gcactttctt cttgcgcaga gaatcaagca tgactgatcc 1794661 agcattcaag ttgctttgta ctaattcttt aggcgtcaat gccatccact gattgagtga 1794721 cacatctgca tagcggttac ttttgaacat ttctaaaaac cataatgttt ctgtaccagt 1794781 gttttgtata tagtgtccgg cattagaagg cacgtatcca acgtcgcctg ctctataatc 1794841 aaatgtgcgg gcagtcccat ttccgataaa taccgtcatt cgtccctgtc ctgttagata 1794901 atattgccac tcatcgctat tgggatgcca atgaagctct ctcatcgcgc caggctcaat 1794961 ctgaacaagt gcagcggcta tcgtttttga aattgggaag ttagaagaat ccacaattcg 1795021 tacactcccc cctggcattt gaattggggg ttgatttaac agctcgtgtt taaaggtcat 1795081 ggggactttt ccatatggtg actgaatgtc ttcactggcg actgatcccg gcacattccc 1795141 ttggtagata tagacttgct cagacggaag agagttgaaa gcattctccg ggacaccgaa 1795201 atttgcagac agaacatctt ttggtgtgtg tgcaagccaa tctgaaatgg ttaacgttga 1795261 aaactcagaa aagttcccat catcgaaaac gagcagaaac tcgcagtgtt ccaatccctg 1795321 tatggaatgc ggaattcctg ccgggaagta ccaaaggtcg ccgggaccaa catcagcaat 1795381 gaaatttcgt ccgtcttggt caacagcggt gatacgtgcc cgtcccaaaa gcatataagc 1795441 ccactccgct tgcttatgcc aatgaagctc gcggacgcct cccgcagtta agctcatgtt 1795501 tacacctgca atcgcagtcg aaatcggaag ctgtcttacg gtgatttctc ttgaccagcc 1795561 gccgtgatct aatttcatgg gagcgtctga gaatgaaaat ctcaagttag gaatcatacc 1795621 ctcatctgta acaggcggaa caaatatatt cggattttga atatcccgta ttatatttcg 1795681 cgggcctgta tcaatagctc cagctccatc acttcgaata ggctgcggca cgtttctgtc 1795741 ttcatgattg attggttgtt gttccaacag catgcacctc gttttagaaa tgaacaagat 1795801 tttatttcag cctatgcaga atcttagatt gctgtgccta ggaatccgca aataaaaaag 1795861 tgaccaccaa tgtgatcaca aatacatcaa ataaactatt ttttatacca tggcttctta 1795921 tgtaatttga ttgcttctgt ctgttttttc tggcctgtcc tccactccac ttttactaat 1795981 acatcatgac ctatcacttc atcttcaggc atataatcaa aggtggaaat atggtcctcc 1796041 atgcgtcccc cacccggcat ttcatcacct gtgtactccg ataagtcgta ctcatctacg 1796101 ttatcatctt gatacttttc gccatctaca tacagagtaa ttctttcaac aacagtccac 1796161 ttttcttcct tcttactccc ctgccaatat agatttagaa aataattggg tccaattgaa 1796221 gttttgtctg atttttcaag gttagacatc cacagtccgc ttttcccgct gccctcatat 1796281 ttcactttgt tccctgacac cattacaaat aatgtgatga tgcagatgat caagaatcca 1796341 gcaatgatca atagccattt cttaatattg ttcttttttc tcatgttttt cctcactttc 1796401 ctaacttttt agtaggaaaa tacgatcaaa atgttaccga aaagaaaata agaaagggct 1796461 aatgatctaa cagatgactg tctaaacttt tgacttaaat taaagtgctt tctaaagaca 1796521 agattaaaac gtataacagc tcttaaatgc attttttgtt tcattgagtc aagaacctta 1796581 aaatggcttt ttattattaa aaatcaagct agtgtattaa gtaacttttc aaatttattt 1796641 atactcatga tctcgtgagt cacaaatctc ccatcaaaaa aaacgctaaa agttgtccaa 1796701 atagctggtg acttttgtgc ctcttctttc gatgataact gaattgactg aaattgaacc 1796761 cctttctttt cagtcaattc ccgcaaatca tttatcatgc ccactgcaaa cggacactga 1796821 gctgtatagt atatcgtaat ccccttttca ttgatagaat cacttttcac ctggctctta 1796881 aatgcaggag aatctgcaag gccattccaa gtcaaagcca ttaattgaaa ataaggggca 1796941 gcttcatctt gtagagtaaa ccccatatgc tcaaagaaat gcttatcact taaatagggc 1797001 agttttttct tgcctgcgat atggataatg ccatccatgc cgcacgcttt cgcatctgct 1797061 atacatttgt ccaacaatcg tttcgcatga ccgttatttt tatatctgcc agacacccac 1797121 agacaattaa tgtacataaa attaggcgca ttgataggca cccatgcctc attcgcaggt 1797181 aggtattcaa taaagacttt tgcccgttca tgtaagcgat agaacaccaa tccttcatcc 1797241 attcgagctt tgagccatct cttcttttca ttaactgcat gctcatattg tttcgtgctt 1797301 aatgcacagc aaatatgatt gtcttcaata ttgtcctttg tgatttcaat gtagcacatc 1797361 tcctctttcc cccctttaac ataattacat ggaattcaac ttcacacttt acatgcctaa 1797421 tagaataaat acccgttcca acttaaatac tttttctttt ccattttgcc aattaactgt 1797481 aaaacccttc ttttattcag atattatctt gattcctata tcacccattt caaatccaaa 1797541 gtgtgttcat ctttgaggat tagatgcact gcttatgcta taaatacagt acacgaagtt 1797601 ttttatttga agtaatattt gttacgggac agcaatagta aataagtgat aaaaggggaa 1797661 ttaaacttgg tggaaaaatg ttattcttgt ttaatttgcg gatacaaagg attaattcaa 1797721 aatcctttgt ataaaggcga gtatcaaaaa acgtttgaca tttgtccatg ttgcggtttt 1797781 gaatttggct acagtgagga tcatgatgtg aggttaggtt ttattgtaac tcctgatcat 1797841 ttaattgagg ctgcatttca attgtatcgc aaacaatggc ttgagagcgg gatggtaatt 1797901 gctcatccgg aagatattcc agaagaattg aaaaatggca attgcttaaa atttgaagtt 1797961 ttgttgaaac aattgaaaaa actaaatctt gacatagaaa attttgaaat tagcggtttt 1798021 taatgatgaa acaggttgca cttgtttagg tttcactgtc attatcagta aaatgttaag 1798081 ttgaaatgcg caatcagtca caaagtctct attcgtattc aataaagact ttgtgatcat 1798141 cgacaaacat ttcactccca tcggataaag tatccaaaag gcctcctctg gttcttctct 1798201 atagtcatta atcacagtca ctttgacatt tgactcagct atgattggtt ttccaacaat 1798261 ttttcgtttt ttcctcaggc aaagtaagag atcgaatcat caaagccatt ccatctttac 1798321 tgtctaatta acgccatctt cagtgaattt aaaggtctgt tttaaattgc gtccttcttg 1798381 ccccttctgt gtccaaatta taacaacctc taattcagag gccttatctg ccagcataaa 1798441 atgattgaac ttcagcggtg agccatcatt taaactttca gctaacattt tagaatcttc 1798501 ttttggtttg acacaatttt catcgggaca tccaaaaagc gaaaaccttg tgattgaatt 1798561 agggtcattt ctatacaatt gcacatccac tgtagctgct ttttccccta tatttttgac 1798621 ttccaaggaa tatacttgat attctccttt atgaggtctc gtaaattcct ttacattttt 1798681 tgcttcactt acttttactg accactggtc tgttttttgt gtaataggca acaccgtaaa 1798741 agtcagggca tgcgcttttg attggcaaaa cgtaaatcca actgctgtaa aaacaattac 1798801 agaaaataat acccttttca cttcatttat ccctccttcc tttcactggc cgctccttaa 1798861 agaattgatt ttgagcaatc tacaagctct cttaaccaaa accttacctg aggttttgtc 1798921 tttactgctc tgcatttatt tctttcggta tccgagaagg agctttgggg atttttctca 1798981 atctgctgtt aatcacatca gaagagtata gcgtaataat catacttccc ccataccttt 1799041 ttgcccgaat taagattggt tggttatatt ggttttgaaa gcgaaagtca ggacctcccc 1799101 agcttaccgt cgcatcccgt ccgggcggta catatggtac acttctagta tgagaatagc 1799161 gctgaacgat ctgcagtcct gcacgatcta ctgcattaaa tagagttgag gacacctgac 1799221 aaattcctcc tcctacacct tcagacaact ccccttttac aataatgggt gcacttttat 1799281 atcctttgtt ccgagttctc attcccacaa cttggttaaa cgaaaacgtc tcattaggga 1799341 aaacaacgtg attgtcgatt gcttttgcag aaagagaaat attgtgtgaa cggcttttat 1799401 tgcttgagtt aaaatacgtc acgtactgac caagctgctg cgtactgatg tgagctagca 1799461 gctcgctgtc aactttcgga taaatgttca tttccggcac ttctatcttg gagggacctt 1799521 gcccataaaa atacgcataa aacttttcca taaacgcctg ttgatacagt ttgtagccaa 1799581 ccctgcccgg gacgatgctt ccatgatcgt taaggacagc atttatcggc tcacggtaca 1799641 ctttctgatc aagctgtttg atgaatttac tgtatttttc atagtcaacc attggagtgc 1799701 cgggaagagg cattgtaaag tcttcacggt taacagtggc aatcgtccgt ccttgctgtg 1799761 tgaccgttaa actgtcctgc ggctcactcg gctgagccaa taaaaaaaga ccagtgatca 1799821 aaatttgtat cataagtcgg tttacctccc aatcattagt atgaacagcc gcttatcctt 1799881 tgatgtattt cttcccatcg tttgtttgaa tctttagacg ttgataaaaa ccttcataaa 1799941 agagcttagc tttatgttca caccgatccc tgagctcact gaggcacacg gttcattcag 1800001 tcggcaagtt tgaagtagtt cagcatctcc cagtgatgag ggatgctttt ttgtcttgtc 1800061 aaaaatgaaa agggtctcct ataacaacaa aaaatcaatc catttcaata tttttttatt 1800121 gagaaacgat aaattttttg ttacattcaa ttagacaaca aataaatgag gtgcttgtta 1800181 tgaatcgaat gtcgacaatt tttttaaaga tagctttggt tcttattgga attccaattc 1800241 ttgctttatg cattttttta gtgcctaagg tagccaacta ttcagcagaa ttatttccaa 1800301 atatcgctta tataaaatat ctcgttttca tctatttgta tgtaacggcg ataccttttt 1800361 actttgctct ttatcaagcg ttcaaacttt taagctatat tgacaaaaac aaagctttct 1800421 cgggtttgtc tgtaagagct ttgaagaata taaaatattg cgcagtcact atcagtatct 1800481 tttacgcagc aggcatgcct gtcttttatc tgatggccga gatagacgac gccccgggta 1800541 tcattgtgat cggattggtt attatttttg cttcaatggt gattgcggtc tttgctgctg 1800601 ttcttcaaaa actgttaaaa gaagcgattg atataaaatc agaaaatgac ttaacggtct 1800661 gaggtgatga catggcgatt attatcaaca ttgatgtgat gcttgctaag aggaaaatga 1800721 gcgtaacaga gctttcagag agagttggca tcaccatggc taatctttcg atattaaaaa 1800781 acggaaaagc aaaggctatt cgattatcaa ctttagaagc gatttgcaag gctttagaat 1800841 gtcagcccgg ggatatattg gaataccgaa gtgatgaaga cacaggattc gtaaagaaaa 1800901 aatatgaagg atcaacagaa aaataaagtg attggcggtg agcttatgga cataaactta 1800961 tatccatcta gctgctatac taagcgtccc tttcatacac gaagaacaca actatggagg 1801021 aggcatacat catgagagcc ataaaacaaa tcgtccattt tggctgggaa caagcccttt 1801081 catgtttgtt tcctgccgtt atttttgcct ctttggctat tacgcaaatc atcccactgc 1801141 ccttcttgcc gcggtatgac tggctgctca ttatctgcgt tctcatgcaa ttgtggatgg 1801201 tgcgttccgg tcttgagaca cgggatgaat taaaagtgat cacattattc caccttattg 1801261 ggcttgctct ggaacttttt aaagtccata tgggctcctg gtcttatcca gaagaaggat 1801321 actccaaaat atttggagta cctttgtata gcggctttat gtacgcaagt gtagccagtt 1801381 atttgtgcca ggcatggaga aggcttaagg ttgaactggt taagtggccg tctttttttg 1801441 cagttgttcc gcttgccgca gcgatttatt tgaatttttt cacccaccat ttttctatag 1801501 acattcgatg gtggttatca gggcttgtca tcattgtctt ttggcaaaca tgggttacat 1801561 acgaggtgaa tggagctcgt taccgtatgc cgctcgcact ttcttttata ctcatcggat 1801621 tttttatatg gatagcggaa aatatcgcta cgttttttgg agcttggaaa tatccaaacc 1801681 aaatcgatac atggagtctc gtacaccttg gaaaggtaag ttcatggctc ttgctagtga 1801741 ttgttagctt tcttatagta gcatcattaa aacaagttaa ggagcagagt cccacaaagg 1801801 cagagatgga tgaatctttt tcttagcata cgcatacaag ctcccaaata gagtgaaaag 1801861 caacgttcaa atggttgctt ttttctttta tgtaactctg ccggtgagta ttcatcttct 1801921 tcaaatttca tcgcaacacg ataactgatt cagattacaa ctgctttcaa cactttgaca 1801981 aactcatgcg ccgccggcgt tatctcttca aatgaatgtg cgatgacgcc aatatcgcgt 1802041 gtgaccctag gaaagatgtc ctttttaatc aattgatgcg ggacggatga aagtgtaaag 1802101 tttgaaatga tgccgatacc caagttattt ttgaccatat taatcaaggt ttcggcattt 1802161 tgcacagtta agttttcctt taattcgatg ttgtattgcg aaaatgcgtt tgacatcgcg 1802221 atttcatgac cgcctttaca aaaaatgagg tcatcttgat atgtttcaag gtcgacatgc 1802281 ttttcaagtt ttaattcgtc acgctgcggc gggatgacgg ccaccatata gtcgttacac 1802341 aatagctgat tttcaaacgg ttcaaatgga gatgctgcga tcccgatatc aaccgtccga 1802401 tcttcaaccc atccttttat ttggtcagag gttccttcga tcaattctat gcggatcagc 1802461 gggtagtttg atctgaatgc cgcaatcgcc tgtggcatga tatttgttga aactgcagga 1802521 aatgaaccaa ttttcacctt cccgtttaac agcttgtttt cccggttggc tacttgatat 1802581 attttgcttt caattccctt catttgcctc gccagcagca atatttcttt tccgatgtca 1802641 gtcagcatta aaccatgatg tttatccctg atcaataatt tgagctgcag tgagctctcc 1802701 aggtttttta tcgctttact taccgccggc tgagagatga acaattcttt tgccgcttct 1802761 gtaatattta atttctcccc aacttttaca aatatgtgaa gatggttcat gttcataacc 1802821 atttggttat acccccaata ataaaaatgt atttcagtta tacataaatg taacatatga 1802881 tagaaaccag cacgatattt taacaagaaa ggcggcttca ttatggtaaa agttatgctg 1802941 ggaatcatat ctgtcacact tatttggggt tatacttggg ttgcgatgaa agtaggaatt 1803001 catgacatcc ccccgctttt attttcgggt ttgcgcctgt tcatcggagc agttccttta 1803061 tttctcattc tcttcatcca aagaaaaaag ctttcaattc aaaaagaaca tctcaaaagc 1803121 tatatcatca tgagcctgtt gatggggctg ggctatatgg ggattttgac gtatggaatg 1803181 cagtttgtcg attcagggaa aacctctgtt ttggtatata caatgcctat atttgttacg 1803241 gtgatcagcc atttttcatt aaacgagaaa atgaatgtgt ataaaacgat gggactggtc 1803301 tgcggcctct tcggactgtt atttatattt ggaaaggaaa tgctcaatat cgatcaaagc 1803361 gctttatttg gggagctgtg cgtacttgtg gcagcgctta gctggggaat cgcgaatgtg 1803421 ttcagcaagc tacaattcaa gcatatcgat attattcaca tgaatgcctg gcaccttatg 1803481 atgggagccg tcatgttatt ggtgttttcc tttatatttg aggcggtccc ttcagccgag 1803541 tggacatatc aggcggtgtg gtcattgctg tttaatggct tgctttccac cggctttacc 1803601 tttgtcgtat ggttttgggt gctcaatcaa atccaagcgt caaaagcatc catggcatta 1803661 atgtttgttc ccgtattggc cctattcttt ggatggctgc aattgcacga acagatcacc 1803721 atcaatatta tcctcggcgc actgctgata tgctgcggga tttttatgaa tacatttaca 1803781 ttttcacgac ggaaagtgtg aatgatatac atttcccctg tcatttgggc ttcatgtgac 1803841 aggagaagac tattacgaga aagtcttcta gaatcctgac gacagcctat taaacaatga 1803901 aaaaagctaa tgtctgcatg tagacattag cttggctggc gtttaggctg gtgagaatcc 1803961 agatactttt ttattaccat tctggctgat caaactgaaa accgtataga ccttttactt 1804021 taacatctcc gcaatctgga tcttttgtca aaatcaaata atgagtctta taaggcatcg 1804081 tctcaactcg atcagttgca ctaaaatcaa aatgatcccc cgagaagttt ttttcactaa 1804141 cggttatttc atatcctgac aaagtcattc gcatgattct tgcgttaatt gtacatcctt 1804201 cagtatcgaa aatggtgaat ctgtacccaa agtgagatgt ccaatggttt gaatttaggt 1804261 catcagactt cataaaccat ttttcattct ctgtcattgt aaaactcact ttctcctcat 1804321 ctttcacgat aacggccgaa gcttccccta catggatagt caaagccaaa agaaatgtaa 1804381 aagctaacat caacatcttt ttcaaaagag ttcctcccga tatcttttac ttcaatatat 1804441 tggaagggtc ttttctgatc aagacagtct tctccaaatg aatctttagc accatgaaat 1804501 gagccttaat aagaacagtt ttaacccaaa tcaacctcta ttcgaaataa ggcttaccaa 1804561 tctatattct ttttaaaagt ttctgcattt ctttatttag ctcctagaca catataaaaa 1804621 atgctcctat aagttcagga gcactacaaa aaactgctaa agtgttttct atcgatttat 1804681 tgtattcatt agctcaaaga aatattcagg cttttgagtc ttatttagct tataccatga 1804741 acgcaatgta tctggtgcaa atacatctaa ttttttcaat acttctaccg caaattccag 1804801 aggagcaatt cctgatgcag taaccaaatt ttcatcagat actgcaggcc ccttttcata 1804861 gaatgtttct cctttgtaat tagggcagac catattcata tagtcgaggt cattgcttgt 1804921 gtgctttctc gaatttaagt atccttcatt cgcgaggccc aaggttgccc cacaaattgc 1804981 agcaatagtc gtgccgagct ttaaagcgtc gccaactttt ttcaagatcg gctgatgaat 1805041 atcttctccc caagtgtttc ctccgggtaa aatgataaga tcttgactcc caagagtaca 1805101 ttcgtcaaga gaaatatctg gttttatgct taatcctccc aacgtagtta tcatttcttt 1805161 attaacccct actgtaacta cttttaaaga tgctgcatct tgtttaaagt atctccctga 1805221 gtttagttcc gcaattaaat atccatattc ccagtctgac attgtgtgaa atacgtagag 1805281 ataaactttt ctcgtttgca tccaataaca ctccaatcac aattgataaa gctttctaat 1805341 agatgacttt gctgacagtc attgtcagct tttttgttga ttctattctt atgcccttgt 1805401 tctcccaact tataaaaata taagatcaat tgattctatg tttactagcg caaaggggtt 1805461 tgttacacta actgtcatgg gaaacatttc aaaggtaata caaaatcatt tgaatgagga 1805521 ggcctgatga agttgaaaac taaagcgtca ataaaattcg gaatatgtgt tgggctttta 1805581 tgtttaagca ttactggttt cacacctttt ttcaactcaa cacatgccga agcaaaatcc 1805641 atagaagaca caaacatggc aagctgtata acgaataaaa aatttgttca acttgagaaa 1805701 aaatttgatg ccaggcttgg tgtttatgca attgatatag gttcaaacaa gacaatcgcc 1805761 tatcggccga atgaacgatt tgcttacgca tcaacctata aagttctagc cgcagctgct 1805821 gtcctgaaga aaaactcaat tgaaaaactt aatgaagtca tccactacag caaggacgat 1805881 cttgttacat attctccaat cacagagaaa cacctagata caggcatgag cctaaaagaa 1805941 atctcggaag cggctatccg ttacagcgat aataccgctg ggaacatctt gttgcaacag 1806001 cttggcggcc ctaaaggttt tgaaaagtca ctgaaacaga ttggggatca tgtaacgaaa 1806061 gctaaacgat tcgagacgga tctaaactct gcgattcctg gtgatattcg tgacaccagc 1806121 accgcaaaag cactggcaac cgatcttaaa gccttcactt tagataacac tctcacgact 1806181 gacaaacgca tgatcttaac cgattggatg cgaggcaatg ctactggtga cgaactgatt 1806241 cgggcaggcg ctccaatagg atgggaagtc ggcgataaat ccggagccgg aagttacggg 1806301 acacgaaacg acattgctat cgtttggccg ccaaacagag ctcctattgt tgtggcaatt 1806361 ctgtcaaacc gctttacgaa agatgctaat tatgataatg ctcttatcgc tgaggctgca 1806421 aaagtcgtcc ttaacgatct caaataatat gtttagcctt ttgccacaaa ggaaaagaca 1806481 ttactttttt aacttctacc gttcattttt tgatgaacgg ttctttcata agacctctag 1806541 aatcatatat ttaaacacca caaaattaaa cattattata attaacagca agttttcatt 1806601 ttatggaaca agtaaagttt gaatctgaca agaattaaga ctaagcaccc taaaatccgt 1806661 tttcttttct tccaagaata tactccttag tgcaagccat tataaagata caagtgaaca 1806721 tacaatgcag acaactctct taagtctctt attctgtgac caatttgtaa tactcatgaa 1806781 tatccggact cacttccaat atttcgtctc gttcgaagac actaacatat caaaccactt 1806841 gaattaacat aactgaactt gatattggtc actggcagtt tcaatgcaat agaacaacat 1806901 ttgttgtctc agaggttatc tatatgagaa ttcaacaatt tttttataat aattcatatt 1806961 tttgtatcgt tgcacttggt ggatttgact cttttcgtgt atggaaccac acttttattt 1807021 tttcacctct tttgagatca tctgtgttat caatctcact taatcctaca attactatgt 1807081 tatttttaaa cttgttcata agttgtcctt cagaaagatt gtaatcttct tttcctggag 1807141 cttttgtatc ggtaatgaga attgcccttt cattgtcttt aagcacgaca tagcctacta 1807201 ggctctgcat ctttgtttcg tctccgtttt gttcattttt attgcagcct gcaaggaaaa 1807261 taatgagcat aatgagcact atcaagctta ctccgatttt aggcatcttt cttcctcctc 1807321 tttaaactca tctttaaaat aaacaacagg atatcaccca acccatctac ttctttttgc 1807381 aattcataac agcagcatac tcattctcca attcctcaac cttcttttta ttctttctca 1807441 aatatttgca tgtggtagcc ctcgatatta tccgcttact catttttgcg ctttcaaata 1807501 tattattgaa ggccgcttct ttctggattc cagcataaat atacttatcc ttactgtcgt 1807561 ttactatcgc aacttccatt aaaatcgaga tttttacttt ttttatgatc cattattcac 1807621 ttccaaaata acttccaatt acaacataat atatgtataa attgtaaatg gagttgatgt 1807681 aattgaagat taggaaaatc ttattgagtt ctgctttatc ctttggcatg ctaatatccg 1807741 cggttcccgc attggctgct ggcacttcgt ctgaggttgc agtaaaaaat gaagaatatg 1807801 attatgacac tatataccgc attagtcctc tgccaatgga cttccagcca acaatagaat 1807861 acaacggtta tacttatacg cttacacgtc attattttga ttactcaatc gggttttaca 1807921 cggctattta tacaaaagtt gtttaaactt ataaaggagc tttttagctc ctttttctct 1807981 tgttttaagc aaggtatttc tttctatgtg gtcccctatc aaatacaaca tcaacattct 1808041 ccagttctct ttgacacgaa caaaatctaa agtttggttt taaatgctgg taataaaaaa 1808101 ttcactttaa agaagtgccg cccgcaaaat acggcttttg tacactacgc caattttata 1808161 ttgaaaagcc agacctcctc aaagaggttc cagcttttct taatgtgcta tcgatcttcg 1808221 ttagttcaac gggaacttta tcattcggta caaatgcagc ctcccaactt ctagttaggg 1808281 ctgatggcgg aatatctgac ggttctctac acacatcaga cattagaaga tttcaatgta 1808341 gccttctgta ccatgaacgc gaattcgttg cccatctttt atcagcttgg cagcattttc 1808401 aacgccaaca actgcaggta agccatattc acgggctata acagctccat gggtcatcag 1808461 ccccccaact tcggtgacta ggccttttat ggatacaaac aatggtgtcc agcttggatc 1808521 ggtaaaggag gtaactaata tatctccatc ttctaaatcc gcatcttcca tgtttaaaat 1808581 gacacgcgct cgcccctcta taactccgga ggaaacaggt agacctacaa tcgctccggc 1808641 tgggagattt tctcgtttat actcacctgt aacgatttca ccatcagacg tgataacacg 1808701 tggtggagat agtttttcat ataatgtgta ctcgtctttt cgtgtactga tgatttgata 1808761 atccagttta tgtgtgcgca cgacttcgtg aagttcttca aaagtgagat agtatatatc 1808821 ttctttttca tgaataacgc ccgcttctat gagttgttcg gcttctttca gtaaagcctg 1808881 cttataaacg aagtatcgat taaccatgcc gtattttgga tattccctaa acccgctgaa 1808941 attccggatg atatctatcg ctcgttttgt ttctttggct ttttgttcac catccggtaa 1809001 ttgcttcaat cgatctaata actcttgttc tttcttcaaa gcttcctgtc gcccttgctc 1809061 aaatttccga tggccgacat taggctcaaa atttttaata ttattaagaa tcattgggac 1809121 aagtgtagtt ggtttttcgc tccatcgagt tcttgtgata tcaatctctc cggtacatcg 1809181 cattccgtat ttgctgagat aatcatagat cgcgtctcgg gttttgcttc cgccatcaaa 1809241 cttagccagt tcatccaaaa agttatcatc ttttacatgt tgtaagtaat caattacctc 1809301 tggataagga cgaatcacat ctgcgacgtc taatagcgca agacccattt ctgaagtaat 1809361 attatggggt acagattgag aaagcgtatc tgctgcgttt ttttcaccta accactcgtt 1809421 cattttttcg ttaatccata atgaagcatt catagcagtt cgaattagaa ccgaactttt 1809481 tgggttaaat aaaatcttct ttaattcctg aatatcttcc agaataaaac gaaataaatc 1809541 tgatcctgat ttcgtttgga tgttttgttt taactcttct atcgatgttt gactgctctc 1809601 aatcaaatca gacacgattg tcggatcgtt ttcaacttga gccggcatat ctgcattgcc 1809661 tctgctggga tttggtgctg ttttatcatt tggtatcgac tttatgaaat ctcgtcgctt 1809721 tattatggtc ataagtgcgt cttttaagag ctgatcgtgc tgccccatgc cttttaagaa 1809781 aacttctctg ctgtcagggg atgccagatg atgtgtgaca tcaacaaata gccttccacc 1809841 ggctttacgc atgggtgcaa cagtcgtcaa cagaaaaaaa gacaatccca gtggttttat 1809901 gggatccgtc atcatttgtt gatgaccaac agaaatatag acgtgatttt cttggtcact 1809961 cgcttcaggg atggggaata aagtagtgat tggacgactc tgtacaatat aaaaagtatc 1810021 gcgggccaaa caccattcga tatcttgcgg ctggccgaaa tgagcttcga tctgtcttcc 1810081 aatgcgtgcc agctgtaaaa tttgttcatc agtcagtgtt tgagcctttt gctgatcaga 1810141 atcgatctgc tgtgtttctg ttccgccttc ttttcgtccg tagatagcca tttttttagt 1810201 tgctattctc ttatcgatga tttgcccatc ctgtacttta aaacaatcgg cagataccaa 1810261 gccagaaacc agtgcttcac caagtccaaa accggcatcg atggataaca cctttcggtt 1810321 ggaggtaatc ggatcagcgg taaataaaat ccccgaagcc tgagggaaaa ccatcctttg 1810381 aacgataacg gataaataga cttggctgtg gtcaaatcca ttttgcatac ggtaaataac 1810441 cgcgcgatcc gtaaataggg acgcccagca tttactgata tgctgcaaga ttgcatcgac 1810501 gccggtaata tttaaatagg tgtcttgttg accggcaaaa gaagcatgtg gtaaatcctc 1810561 agcagtcgca ctagaacgca cggcataggc atgttcctcg ccaaactggg agagatattg 1810621 agccactgct ttcacaacat cggaaggaat gtctacttcc ataatgattt gccgaatctt 1810681 ccggctgatg ttaccaatct gatctcggtc ctcaactttt agcatggtca attgatccaa 1810741 caacacttgt aacgtttcgt tttgttcgat ggctttttga tatcctactg ttgtgacaca 1810801 aaatccttct ggtacttgta taccttgaat ttttgataat tcccctaaat gtaacccttt 1810861 tcctccaacg agcgaaagct gtgttttttc aatttcatgt aaaccgagaa ccaaagaact 1810921 cattctacat ctccccttca aaaaaaaata ttgacaagag cttcctagca ggatataata 1810981 aaattataag atggatatct ataacttttt aactagaaag cgcacgtagt gtgattatat 1811041 caccgtgtct gtttttgtgc aatataaaaa gaacctggga aatttcacca ggttcttttc 1811101 ttaatttcca tagctagtcg cattaaaaaa cttggtttga gctgattcaa tcctctaagg 1811161 aaatcctaaa gttgggttct ttttgaactt acttgctttg ttcgtagagt ccccattcat 1811221 aaattggact ttttgttctt aacagtccca cctttaacta gtataaagtt atgaggatct 1811281 ggttaactac tagatatttt tattttgaat aaggcttatg tttgataaag aagggttatg 1811341 taaaggtgtc tgttgtgagc aagcgctgac tacaaaaaat tgatagcatt ctcatttaaa 1811401 taccattcta ttaacctata gggaaagttt taaaaccaga tggagaatac cctacctcca 1811461 gcaattccaa ggccgttcac ctagtagaaa acaaccttta accattacta acgattttaa 1811521 taatcattga ttataaaact tctcaaggaa cgatcagcag cccgttagct acccctgatt 1811581 aaggatgatc tgttaccaca ctgttacgtt agaacttcca ctactttgat atccttctgt 1811641 cgccatgact tggtaagccc aattactgcc cagattcatt ccatggctct tccatgcgtt 1811701 cacatgattg ctgaaagtga ttgtagcgtt gcttccggtt ggtctcttcg actggcgaac 1811761 actccagtac tgcgtaaaag tagtgcgatc gccatcaatg gaaggtgcgt tataacgtgt 1811821 agttgtatat atgtcatatg tacccccatc actttttaca gtacctttat acgttccagt 1811881 aggtctataa gtaccccatg aatccactac ataatattct atgagaggtg atctcgtcca 1811941 accatataaa gttaaatatc cattgccatt cggcgcccaa actccggcat tatagtttat 1812001 cgtcctaaat ggcgaacctg tagtccaacc tttaccaaca acaaaatttc cggtattaga 1812061 ccaattaaca ctgtaattcc cgccagaccc attgacagcg tttactatac cgcccccatc 1812121 agtccaattt tgccagtagt ctgtgctagc tgcagaggcg gttgccgaaa acaagctaat 1812181 actcattaaa gctgccgata atccaactaa gaaattcttt ttaaacttaa acatatgtta 1812241 cctcctataa tattttttcc gactttgagg tagcactcgt atacatttaa aacattctta 1812301 attactaacg ccaaagcttt tgatcgtccc cttcagtata ataccacgaa ttcatgagca 1812361 aatattaaaa gtatttgtaa ttcaattaca aatacctaga aacacattat aagtggtctt 1812421 cttccaccat atcctgatcc gagctcgatg tacatgcctt tacggcacac acgaatgtgg 1812481 cgtgtggtgc atcgcctcaa tacgcaaaga cgtttgcctt aggcaaacgt ctttttttgc 1812541 gttatccgat ttttgtgccg tttgggacag gctgatccgg ctgcaaaagg acgacgtcgc 1812601 cctggccggg tatgccgccg aggaccaaga cttccgattt aaatccggcg atccggcggg 1812661 gcggaaagtt cacgactgct atgacttgct tgttgatgag accttccggc ttgtaacgct 1812721 tcgtgatttg tgcgctcgat tgttttatgc cgatttcagt cccaaaatct atcacaagct 1812781 tgattgccgg tactcttgct tcaggaaatt cttccgcttt tacaattgtt cccgttctga 1812841 tatccaattt ctcaaagtca tcaataactg ccatatcaat aactcctttt tctcctattg 1812901 taaaggagat atacaatatt cttttaacta aagagccatc attttttatc cgaatataag 1812961 gtgtttcgat acaggcgggg cggcattcct gtgcttttcg tgaaccatct tgtaaaagaa 1813021 gaaaggtttt gaaagcccag cgcctcgctc acgacggtaa gagtttcatt tctctccatc 1813081 agcattcttt ttgcttcctc aaggcgaagg tcggcaatat agttctgcgg ggacttccct 1813141 gtctgttttt tgaaccagct tgaatagtaa gctgggtgat aatgctcgat ttctgccagc 1813201 ttcttaatcg tcagccgctc aaataaatgg ctgtgaatgt atgcaattga ggcatagcta 1813261 tgggattgaa gcttttcttt tatgtattgt actagcatat gaagcgagtt ggctgttccg 1813321 gcctttgctt cctctgtcag caagtacctg atcgaagacc agaaaggatc gagggcagct 1813381 tcaattcctg atcctgcacg atactcatca attttcattg catgaagcgg aacatccagt 1813441 acaagacatt catttcttcc gatagaacgg aagcgatgct cgcactgcgg cggaatatat 1813501 aaaaaatgat ccggatttaa tttcacctgg cgcccctcag tctcaagatc aatactccct 1813561 tcaagcggaa aaagaaattg gctgtacgcg tgcttatgtg aatgatatag ccgtgtgtat 1813621 gtccgttttt cgcaaattat ctcttgaagc gagtccatta gcaaacccct tcctttggtc 1813681 atcttttaat ccggtaatgg tgttccgata taggcgaaaa gccgattttt ccatataaag 1813741 aaactgccgc cagattttct ttcatcactt gtaaaaacat gcgttccgct ccgttgtttt 1813801 ttgcccattc agtcaacacc ctgatcactt gggttcctgc cccttttcct ctgtgctcct 1813861 cagctacaac gatattacta agtccgccat aaccatcaat gacagaaacc gtgccaagcg 1813921 ctgtcaggct ttctttgtca tacatcttga aaaaagtttt acacggcggc atgcgttcga 1813981 atatgtgttt gtaacctttg tgacgctcgg gtgaaaaccc ttctaattga ataaattcat 1814041 ctatccaaac agatgatggc tcttgttccc acttgtatgt aaatcggctg ttgtcatttg 1814101 ttcggctcat aattgaccgg cacaacgctg tcatctggaa gcactcgtct accttttcat 1814161 aacggctgtc tgccaatgcg tcatcaagcc ctttcggtga tgcgttgcta atatgaaaac 1814221 aaacaggtaa gcctaaactt tgataaaaaa gttcggcctc tagctgaaaa tccccttcag 1814281 gcatatccgc agacgtccat acgctatttg cccttttggt tacgccaaaa ttcgctctga 1814341 gaagccattt ccctatgctt ttttgaaaat aagccggcca tgaagctgcc gctaatcgtt 1814401 caatcttgcg aatgtcatcc attgcataat gcctctcccc tatgtatact cccttgatat 1814461 tatacaatat tcagaaatat aagacatcca tttatttgtt tacataatat ttttattgtt 1814521 tattaataat cctgacaaaa atgtccgaat tgaaaatgac aggctttcta aaatgtcctc 1814581 ctcacgttca aatgcttctt ttgcgattaa aacagtaaag ccatgcagca gacttctgag 1814641 cccccttgtc gcatgaatgg cagtcttttc acttgcatag ccgttttcaa tgagcagctt 1814701 cgtcacaaga cagacaattt ggtcagagac gatttccgtc cgtttgtcgt gaaccttaag 1814761 aagagccgct tcataatatc cgggattttc aattgcaaaa tcaacatatg catgagctaa 1814821 agaaagcatc gcggaatctc cctttcgttc ggttacggag tccgccattt gatcaaaaag 1814881 ctttgtcagt cctctgacag caagttctgc tctgatcgct tgcagcccgt tgatatggtt 1814941 atacaatgac ggggggcgaa cattcatttt tttagaaagt gcagcaagtg agacaccatt 1815001 taccccttcc tgatcggcaa tctctgctgc agcgtctaca atcatttttt gggtcaaacc 1815061 tattctcggt gacatgctca tcatcctttc tttgcttttt ggatcgcctg tctcatccgc 1815121 tctgaaggtg atcgcaggaa ttttccatgt ccgacagcga gacaggaagg cgccttatcg 1815181 gcgagcaatt gtgcactttt gatggcctcc tccttattcc atgtggcgaa agcgggaaaa 1815241 ggaaacgccc attttatctg acctgataca gcgattcctc cgcgcaactg aaacgcatct 1815301 cctgctatta aagtgccgtt tcttgtatca agaaatgaca tgctgcccgg tgtatggccc 1815361 ggtgttggaa tggcaagcag agaaccaatt gtttcaccgc ccgtcagcag ttggtgaggc 1815421 tttgtttgta tgtgtttcgg aatacctcct tttataggcg tctgcggctc atcttgccgc 1815481 aaagatgtgt caccttggag caagaatgaa tcccgttccg agatcatgac ctttgcatgc 1815541 ggaaatgttt gtgccaatgt atccagtgat ccgacatggt ccccatgtgc atgagtcagt 1815601 aaaatatgct gaagcggttt tccaagctga ttcacagctt gaataatccc tttatagctg 1815661 cctggcagtg cggcatcaat aagggtgact tcgttttctt cctctactaa atagcaatta 1815721 accggaaaca atgctggaaa aaaagtcagc tgccaaaccg tttggtactg agtaattctc 1815781 atctttttat tcctcctaac aaaaactaat ggtgttagtt ttattattaa ctaacaccat 1815841 tagtttttca agagtttatt atttttttat cgctacataa atgttaactt gtgctcgctg 1815901 tggcactgcg gcattttgat catacatctc aaagtcacct gtaaacgtgc gcagatgccg 1815961 cttatcccaa gtccaaattt ccttccacgt ttcaagcaca atctcttcaa taggaccgat 1816021 tctggaagtg aaaacggcgt aagcggaagc cggcaaatca atattttcat atggtcccgg 1816081 aagaatgtcg tcgtattcct gaaacgttcc gactgaaaac gtataaaacc cattcgtctc 1816141 ttgttcataa ttcgaatata aggcaataat gctcttgtct ttttcagcct gtgataaaag 1816201 agcgctcata tcctgcttcc ataattgatc ccacagtgcc ggaatcctcc tttcttccgt 1816261 catttccagt gcgttgcttg tccgttgtga tagtccggca aatcgtttca ggtctaagtg 1816321 tgttatatgt gaaaagccca tacgatctcc tccttttttt aagattatag acaaagaaac 1816381 ctgacagcag tgtgtcaggt ttcatatatt ttttgcatgt gatgaatggt ttcttttact 1816441 ttatccctta tatgaagagg ctgcagaacc tcaatatcct ttccgaactg gagcaaaaaa 1816501 ccgatcagcc attgatcttc tggaagtgaa atcaccgcct ggcagatttc atcttcctca 1816561 caacagtgaa ggacatcata tccgaaccat tcacctatac gctgacgtgc tgacggctga 1816621 acaagaataa ccaattcagt taaacggtcc ttttggtacc aactcttatc ccatggcaaa 1816681 gtgtccagct gaatgtcttt tctgataaat gtctgatgta agatggccag atctttcatc 1816741 cggttcagtt taaaaaagcg aaaatcattt cttaccaggc agtaggcata taaataccag 1816801 tgccccgcct tgcaaaccaa tgtataaggt tcagtttccc gaagtagtgt ttccccgctt 1816861 gcgcttgtat atgtaaaaga tatcgttaac aaccgatcga tggcagcgct gattttctcg 1816921 cgcagcgtct tttgatcctc agtatggccc caagccgtca tgtcaataaa ccatttttct 1816981 gtttggtgct taaatgcttg agtagattgc tcaggtataa ggtgtttgat tttttgatag 1817041 gctgtgctgt gagaaacggg ttcatacata gatgaaacgc tttgcaaagc ggaagcaatt 1817101 gcaaacaatt cctcctcctt cagccactct ctttcaagcc gatacgtttc catgatgcca 1817161 attccgcccc cggaaccctg tgaggtcaca atcggaatac cagccctatt gatcgtctca 1817221 atatcacggt aaattgttct gacagatact tcaaacagct cagcaagctc tgcagcctgc 1817281 acttgttttt tgctgatcaa taacacaacc atcgctaaca aacgttccag tttcattctg 1817341 cgcacctttt cttcttgtat tttccaacaa aacaatcata acattttgat aaagcttggg 1817401 catatctatt atgcggcgga atacacctcg catatgctat gaaaacaggg gtttcccctt 1817461 cttttttgtg ttcagtattt atttcagcta ctatttccga ccggataagc atacacttct 1817521 caacggaggg gatttcacat catgcatctt acacttcaga gcgtttatcc tgccataatc 1817581 atcatctttt ttctgtataa aaaaattaaa aggtccatcg gataccagcc gctgaagccc 1817641 cgctggctgt tcacccgtat cattcttttc tcgctgtttg cttttggact ttcaatcttc 1817701 agcgccattc accctttttt atatggatat ctcattttgg gcattcttgg cggatggctc 1817761 cttgtctttt tcgctaagaa aaacatctct tttgaaaaac gcagaggaaa gatctatttt 1817821 cggactcata tttgggtaga ggtgattctc ttaactttat ttctatcaag atttctgtat 1817881 cgagtgacgg agctttatct tacctcacct gatctaaacc gccttggatc atacagtcag 1817941 tcaatcggaa cggaccctct gacaattggc gtctgttttc tgatagccgt ttattatatc 1818001 ggtttttctt cttttatcat caagctcagc agaaacgaac ttgaacagca cgaatacaat 1818061 aaagaaaaag acatccttgc ccgctaacag cgagttaagc aaggatgtct ttttcaatca 1818121 tgctgtgtat gatggatcat ttgctgaaga acatctaaaa catgttcatc ctccggagag 1818181 taataaatcg atgttccttc tctgcgcgat ttgacaagcc ggagattttt taaaaatcta 1818241 agctggtggg acacagtgga ttgcagtaaa ttcagctttt ctgcaattcc gtttactgca 1818301 tgctcacctt gggacaataa atggagaatt ctgattcggg taggatctga aagcgctttg 1818361 aatgtttgcg cgactagaaa cagcgtctcc tcgtccagat cagcagccga ttgttccgtt 1818421 tctctaaatt cagtcatatg tatcaccttt ctttattcat agttttatct tataacaaat 1818481 gcgcttgagt gcaaaccagc ctgcttgtat tccatttcaa tctcatagtt taaatttatg 1818541 tttcaaatca ggtttttact tggtctgata taccctctta tgtcataata aaaaaggtca 1818601 tactgctcca aacattgagg gtgaaacaca gtgaagaaaa agagaaaagg ctgtttcgct 1818661 gctgcgggtt ttatgatgat ttttgtcttt gtcatcgcct cttttttatt ggtcctgctt 1818721 tttttcaacc gggatttaat caaaaaactt ccgatcgata cgaaaacgat tgttttggaa 1818781 cgtttaaccg attacaaacc cttggtggaa gaagagcttg aaagccaagg actctctaat 1818841 tatacatcac tcatattagg catgatgtat caggagtcaa aaggaaaagg caatgatccc 1818901 atgcagtcct ctgaatctct ggggttaaaa cgcaatgaga taacagaccc tcaactcagt 1818961 gttaaacaag gcatcaagca atttaccctc atgtacaaga ccggtaagga aaaaggcgtg 1819021 gatttggata ccattattca aagctacaac atgggggcag gttacattga ttttgtagct 1819081 gaacatggag gaacgcatac tgaggaattg gcaaaacaat actccgagca gcaagtcaaa 1819141 aaaaatcctg atctgtatac ttgcggggga aatgcgaaaa atttccgcta tccgtattgc 1819201 tacggtgatt atacgtatgc agaaaaagta aaagaaaaaa caaaaactgt tgaagaatct 1819261 ttgcaggttg caacacttga aaccatggaa tccaaggctc atgaataaga gtctatcaat 1819321 ttactgacaa aagcccaaaa atgaatttgg gcttttgcca tgtttacacg taaaaaaagc 1819381 catactgagt atggctttta ataatacggt gaaatcatca aatatacaat aacgcctgta 1819441 aggcttacat acagccatag aggcattgtc catctcgcaa tttttttatg gcgctccacc 1819501 tgcatgctga agcctctgat cagcgtaaac agcgcaagcg gcacaataat tgcagaaagg 1819561 cagatatgtg taattaaaat aaagaaataa atcgggcgca taataccttc tccgccatag 1819621 agcgtgtttt ccgcaatcga gtggtacgtc acatagcaaa tcaaaaatag taatgttgtt 1819681 gtgaacgcag ccaaaataaa gcgtttgtga gctttgatat ttttctgttt aatcataatc 1819741 agcgcggcca ataagaagat aaacgtaaag ctattgaata tcgcattcag cattggcaaa 1819801 atgtgaatat tcgcatggct gaactgatct aatttaggca taaaaaacag cactgcgatt 1819861 aaaccgttaa tcagaactgt cagcgtaagg acaatccccg tgtaattttt cggtttattt 1819921 tctgtttggt tcatttggtg acctctccta atttgtactg gctatccaaa tcgtatgcaa 1819981 attcaaagaa gatgtcaacg gtttcgattg cttcgtcaga aattagacac acttcaaagg 1820041 ccggaggcta ttagccccgg cctgttaggt ttacgcctct tttatcaaat gttcaatgac 1820101 cttatgttca ttttcattca gcaggttctt ttgaattttc gaatgaatgg gtttattcat 1820161 atgctgatcc aagatatcgg ccgtttcttt atccccggca ataaccattc gttcccatct 1820221 tttcgcggca gctttttgat caaggctggc agccagccgc ttatacagtc tcgattggtt 1820281 ctctgttaca tgttccctca tccggttctc ttcaaatggt ggcgctttgt ctacagcgga 1820341 atggctattc ttccaagact cattgatcat atcatactca taacgctcca ccgcctcaat 1820401 ttttcctaaa acagtttcaa taattttcac ttcatgctgc tgagttaaaa taaacgccgt 1820461 acttgggtat gtctggcgca aaccctttag ctgatccagg acagctgttt cttcccagta 1820521 aaatcttgta tctacaggga cttgaagctt aataggttcc catatgccgc tgtcggaaac 1820581 aaaaaacacg agactgcggg gcatgtcttt tcccattgca ttcaagtatt gattcatttt 1820641 agccctgatt ccatccagac acttttcctc ctctggatca ctagctgcca aatactcttt 1820701 taatcggctg aatcctgact ttagggcaat cttccattct cccccctgct gctctggatc 1820761 tctcatgtct gtattgagat acagagagag aattttatcc ggcggttcca attggacata 1820821 ctgtaatttg ttaatcaatg aatcaatcgc cattccgatt cctccttttt cacaggttag 1820881 ttttcttttt cctctcttaa aaacgatcaa acctgacttt ccgctaattt ctagtaataa 1820941 tggaattgtt gtttacaata cgcctctctt ctaatacaat tggtaactgt gtttctaagc 1821001 tgttttttga aaggagtttg atcttgttta ctgttaaaga aaaaaatcgt caagagcttg 1821061 aggaagaact aaatgattta gaatttcaaa tttatcgcat gcaggagaat atgaaggatt 1821121 tatctaaaga tgccaaagtg cttggtattg atcaatcgaa acatgatgag tggatgattg 1821181 tttcctcgat tgatgatggc caaacatgca aaattatgct aactgattgt aaaacggcat 1821241 accgaggaaa aggctgtttt tcacttgtag cgtcttacaa ggacgatgcc attcatatag 1821301 gggatataaa aggccctccg aatcacgggt ttggctccat ttgcatgaaa tatttaaaag 1821361 atattgcaag agaccataat ataccgaaag tcaccggaga catcgccaaa cgggattgga 1821421 atcatgtaga ccggctgatt cacttttatg aaaaacatca cttcaaagta tgtatcgatc 1821481 atgataccca atccggcagc attaagtggg ttgatttgta aaaaagtctg gaagaaagag 1821541 ccaagatatg ctgtaatggt ataaaaccat tgatggaggg ttctatgtac gcctcaaaac 1821601 tgaaaaaggg agacgaaatc cggatcgtgt ctcccgcgac cagcatgtct atattatcaa 1821661 atgaagcaaa aatccaagca aaaacggcgt tagaacgctt aggttatcgg gtaaccatcg 1821721 ctgaacacgc aaatgaatgt aacgaatttg attcatcctc tatcgagtca agagtccatg 1821781 atctgcacgc tgcctttttt gatccaggcg tcaaagcgat tttaacgaca ctcggagggt 1821841 ttaattcaaa tcagctgctg cgttatcttg attacgagaa aatcaaacga catccaaaaa 1821901 ttctgtgcgg ttattccgat ataaccgctc tttgcaacgc tatttatcaa aaaacgggtc 1821961 ttgttacgta ttcaggtccc cacttctcaa catttgcaat gaaaaaagga ctcgattata 1822021 cagaggagta ttttctttct tgctgcgctt cagacgatcc gtttgaaatt cacccctcaa 1822081 gtgagtggag cgatgatcgc tggtttttgg atcaagaaaa caggcgtttt tatcctaata 1822141 acggccctgt tgtaatccaa gaaggttatg cggaaggtac tttaattggc ggaaacttat 1822201 gcacgcttaa tttgctgcag ggaacggagt attttcccga aacagaacat actattttat 1822261 tgattgaaga tgattatatg tcagacatcc atatgtttga ccgcgatctg caatcactca 1822321 tccacctccc cgctttttca catgtaaagg cgattttgat cggcagattt cagaaagcat 1822381 caaacgtatc aatagatctt gtaaaagcca tgatcgaaac aaaaaaagaa ttatccggca 1822441 tcccgatcat cgcaaatata aatgccggac atacctcgcc aattgccacg ttccctatag 1822501 gaggaacatg caggattgaa gctatttcgg gtacatcacg aatatggatt gataaacatt 1822561 aatcagcttg taaatttttt tacaagcttt tttagcgcaa tcggctatgc atgccgcacg 1822621 agacatgaca aatgtcatat aggaggcatg atgtgtgcta ctacaaaaga cttctctcat 1822681 tagcgtatac tgaaccgaga cacacaatga gaggatactt actatgactg aacaaaccat 1822741 tgcacataaa caaaaacagc tgacaaagca agtcgctgca tttgctcagc ctgaaacaaa 1822801 aaacagcctg attcagcttt taaacacgtt tatcccattc ttcggcctat ggtttcttgc 1822861 ttatctcagc ctcgatgtct cctatcttct tacgttagca ttaacggtga ttgccgcagg 1822921 ttttctgaca agaattttta tcatcttcca tgactgctgc catcaatctt ttttcaaaca 1822981 aaaacgctat aaccacattc tcggttttct gacaggtgtc ctgactttat tcccgtatct 1823041 tcaatggcag cacagccatt cgattcatca tgcaactagc agcaatctgg ataaacgcgg 1823101 aacaggagac atctggatgt taacagtaaa cgaatataaa gctgcatcca gacgaacaaa 1823161 gcttgcatac agactttata gaaacccgtt tatcatgttt attctcggac cgatttatgt 1823221 ttttctgatc acgaaccgtt ttaacaaaaa aggcgcaaga cgcaaggaac gtgtaaacac 1823281 ataccttacg aatctggcaa ttgtcgcgtt ggctgccgct tgctgtctga tctttggctg 1823341 gcaatcgttt ttactggtgc aaggcccgat atttctgatt tcaggttcaa tcggtgtttg 1823401 gctgttttat gtgcagcata cctttgaaga ttcttatttt gaagcggatg aaaactggag 1823461 ctacgttcag gctgctgttg aaggcagctc attttataaa ctcccgaaac tgcttcaatg 1823521 gctaacaggc aatattggtt accaccacgt tcatcatttg agtccaaagg tgcctaacta 1823581 taagcttgaa gttgctcatg aacatcacga accattaaaa aacgtaccga caatcacctt 1823641 aaaaacaagc ctgcaatcac ttgcgttccg tctatgggat gaagataaca aacagtttgt 1823701 gtcatttcgg gctataaaac atatacctgt aagccttccg cctgattcac cagaaaaaca 1823761 gaagctgcgg aagaatgcct gatgataaag gaggtcttct aatatactag aaggcttcct 1823821 ttttattgtt ggagggtgca ttctggcttt cacaatgata aagttacaag taagatgaaa 1823881 agctgaaaat gaggtaagat catgattaaa aatcatttta catttcaaaa actaaacggg 1823941 attacgccct atatatggac gatatttttc atcctcccct tctactttat atggaaatca 1824001 tcatctacat ttgttattat tgtcggcatc attttgacgc ttttattttt ttcggtatat 1824061 cgatttgctt ttgtctcaaa aggctggacc atttatttgt ggggattttt attaattggc 1824121 atttcaaccg cctccattac tctgttcagt tatatttatt ttgctttctt tattgcttat 1824181 tttattggaa acattaagga acgcgtccct tttcatattt tatattatgt ccatttaata 1824241 agcgcggccg tcgcagccaa tttcagtctc gtattaaaaa aggaattctt tctgacacaa 1824301 attccttttg tcgttattac cctcatcagc gcaattttat tgcccttcag tataaaaagc 1824361 cgcaaggagc gcgaacgact tgaagaaaag ctcgaggatg caaatgaacg gattgcagaa 1824421 ctggtaaaat tagaagaacg tcagcgaatt gcccgcgatc tccatgatac gcttgggcaa 1824481 aagctttctc ttattggttt aaaaagcgac ttagcaagaa aattgatata caaagatccc 1824541 gaacaagcag ctcgtgaact gaaaagtgtt cagcaaacag cgcgaacttc tttaaatgaa 1824601 gtaagaaaaa tcgtttcctc tatgaagggc atccggctca aggatgaatt gatcaacatc 1824661 aaacaaattc tcgaagcagc tgacattatg tttatctatg aagaagagaa atggcccgag 1824721 aatatctcat tgctgaatga aaacattttg agcatgtgct taaaggaagc tgtcacaaat 1824781 gtcgtcaaac acagccaggc taaaacttgc cgagttgaca ttcagcagct ctggaaggaa 1824841 gttgtgatta cagtgtctga cgatggaaca ttcaaaggag aagaaaattc cttttcaaaa 1824901 ggacatggct tactcgggat gagagaacgg cttgagtttg caaacggaag ccttcacatc 1824961 gataccgaaa acgggaccaa gcttaccatg gcaattccta ataattcaaa ataaacataa 1825021 aggatggctt atatgattag tatatttatt gcagaagatc agcaaatgct gctgggcgct 1825081 ttaggatcac ttctaaacct cgaagacgat atggaagtcg taggcaaagg tacaaccggc 1825141 caagatgctg ttgattttgt caaaaaacgc cagcctgatg tatgtattat ggacattgaa 1825201 atgcccggaa aaacagggct tgaagctgct gaggagctaa aagatacagg ctgcaaaatt 1825261 atcatcttaa ccaccttcgc cagacccggt tactttcaga gagctattaa agctggcgtt 1825321 aaaggctatt tgttaaaaga cagtccgagt gaagagctgg ccaacgccat ccgtagcgtc 1825381 atgaacggaa aacgcatcta tgcacctgaa ctgatggagg acttatacag cgaagctaac 1825441 cctcttacag atagagaaaa agaagtgctc gaacttgtgg ctgacggtaa aaacacaaaa 1825501 gaaatcgctc aggaactcag catcaaaagc gggacggtgc ggaattatat ctcaatgatt 1825561 ctagaaaagc ttgaagtgaa aaatcgaatt gaagccatta cccggtcaaa agaaaaaggc 1825621 tggtttaaat aaaaaaggat cttggcatct gccaggatcc tttttgttaa cctgaaattc 1825681 ccgtttgaga acctcgtcgc aaccagaatt aaattgatcc atatcctcgc tcctacgccc 1825741 gctgaacgat tgtttggtta acagcccaat aaaagactgg attgaatgat atccctgtta 1825801 aaatggtcgg ccattgcaca tcagcagaat ttctgatatt gattatattg tattttcagt 1825861 atgacaaagt tgtgccactt cgctcccgaa gctgccatgc ccaactgcaa gagcctaata 1825921 tcacaataaa aaaccgtctg aaatcaatcc gattccgtaa atggtatctg ctacatccaa 1825981 ctgcttatta tctgccaaaa acaccagctc gtttcgctga tcaaagatag taacaaccag 1826041 ctataaatgt catgatgccg aatgtctctg taatgtggaa tcaatctttt aacccgagag 1826101 cccctgaatc gcacataaag aaaaacggga ccactttctt ttatcagcat atgatataaa 1826161 cagctctaag cagaacaaaa aaagacacaa gccaaaagct tatgtctttt atcacaatct 1826221 atattattag tttaagactt taacacttac agttttgacg ccccaattag aagcatcact 1826281 tttacttggt acaaatacgt cgattttatt tcctttaata gcgccgccag tgtctgctgc 1826341 tgttgcttcc ccgtagcctt caacatagac tttagaacct agcggaatta cattaggatc 1826401 aaccgcaata actttcgcgt tcgggttctt atttaagtca atgcctgtag ctgtaacgcc 1826461 ggaaatgccg ccgtcgttag cagtgtaagc agtagcagta actgttagtt cttttgaagc 1826521 ttcttgatta tttgtatttg attgaacagc cttctcctct gtgttaacag aagtttctgc 1826581 ctcagccttt gtttcttgtt taggttgctg ttgtacagct tcttgtttag gttgctcttt 1826641 ttgcacagcc tcttgttttg gcgcagcttg aggtgcgttt gtttgcgcat tctcagtagc 1826701 tgtgtttgct gctgttgcct gaccttttac tgaaagagtt gatccagcat agatcatgtc 1826761 agagcttaag ttattccaaa ctttcaggtt gttgactgtc gtgccgaatt tttgagcaat 1826821 cttagaaagc gtatctcccg ctttaattgt atattgccca gtcgtggttg tttcttctga 1826881 agaaatggtc agtttttctc ctgcaatgat tttatcagaa gttaacttgt tccattcttt 1826941 taagtccttt aggttcactc catttttctg agagattccc cagagcgtat cacccttttg 1827001 caccgtaatt tcttttgcag aagcgtgagc tccgaatgca gttgttgaaa gtgcagcaac 1827061 tgccacaaag gacataatcg tcttcttcat aagtaaatcc tcccttgtta gctttttatt 1827121 ggcggctaac aggtgatatc gtaacacacg taaatgtcaa atcaataaca aaaagatatg 1827181 atttagatta cagttccttt acatgaagga tttctctctg atggaaagac ttgctgaacc 1827241 cttgatataa taggcttcgc aggtcttttt attttgaggc gaaacagaga aaataaaatg 1827301 tgttttttat agaaaaaaag attgtttttc tgttttttta gtctgtcatc cttgcataag 1827361 cctgtatttc ttgtaaaaaa agccggccgt attttgctct tttttgttct ccgactcctt 1827421 ttatagacaa aagttcatca tcatttacgg gctgttttcc tgacatttct tttaacgttt 1827481 ggtcagagaa aacaacaaat ggcggaacac cctgctcagc cgcaatttct ttccgaacca 1827541 tgcgcaatcg ttcaaatagc tcgtcatttt cagtaatcgc tgccgctttt aacgcttctt 1827601 ttctcgctac tgataattct cctttcagca cattccttcc tttactgctg acaaaaagag 1827661 tcggaaacgt tccgtctgac atcctgatga agtcgtcaga aataagaaat tcgataaaat 1827721 cactgatttc gccaacggat tggtgtttta atatcccgta tgttgaaagg tcggaaaagc 1827781 cgttttcaag aactttttta tttttggagc cggcaagcac ctgggcaacc atcgtcttgc 1827841 caaaccgttc tttcatgcga atgatacaag ataagaccat ttgcgcctcc cgcgtcacgt 1827901 catgggccgc tcttgtatcg gtacagtttc cgcactgtcc gcacgcatca ggctcctttt 1827961 ctccgaaata cataaggata aaacgctgca gacaatcttc cgtatgacag tagtcgacca 1828021 tttgtctcag cttttttaaa tcctgctttt gtttctcttc atgttctgat tgctcaatta 1828081 agaagcgctg caccataata tcctgcggtg aaaacaggag aacacattca ctggcaagac 1828141 cgtcccgtcc agctcgtcct gcctcttgat aatagctttc catatctttc gggatttgtg 1828201 catgcagaac aaatctgata tttgatttat caatacccat tccaaaagca gaggttgcca 1828261 ccatcacttg aagctcatca ttaagaaatc tttcctgctg ctcttttctc acatcatcag 1828321 ccaaacctcc atgataccgg cctgccctga cctgatttcg tttcaatctc tcatatatcc 1828381 gatcagcttc ttttctggtc gctgtataga caattcctgc ttcatgcctg ttgttttgca 1828441 catattcgtc tataaaccga tctttatttt ctccttttac tactttaaag gttaaattct 1828501 ctcgggaaaa tccggtatat accgtgtttt ctttttgaat atgcagctgt ttgcaaatat 1828561 catcatgaac ctcgggtgtg gctgttgctg ttaacgccat gatgacaggc ttgtcgtgta 1828621 attcacggaa caagatttca atattcctgt agcttggcct gaaatcatgg ccccattgag 1828681 aaatacaatg cgcctcgtct attgcgacca aaggaacatc tatgccctgc aaaatccgga 1828741 taaactctat ggacgttagt cgctctggtg taatgtaaaa aagcttataa gccccttctt 1828801 tgagtccgtt cagcctctca tatatttcct gattggattg tgtgctgtta atgtaggcgg 1828861 cgttaatccc cgcttcttct aacgcatcaa cttgatcctt catcaaggaa atcaacggtg 1828921 aaatgacgat cgtcgtccct tcaaacatta atgccggaat ctgatagcaa atcgatttgc 1828981 cgcctcccgt cggcataatg caggccgtat tttgcctcgc ttccgtcacc aagcggatcg 1829041 cttcatcttg gccgctccga aacttctcat aaccaaaata atgagccaga agggattggg 1829101 ctctatgtaa cataacgtgt aaacctcgct tttccttgaa tttctcccat catatcataa 1829161 aaaagcggcc ttcatttctt tcacacaaaa atggaatatt cactatacca aaccttttta 1829221 gataaaataa aaagccattt ccgaaaagga aatggctttc gctacgtctt gccgtatgca 1829281 agtaagaaag ttttaaacca ccactcctca aagtgggtgt ttgcagaaac gttcctgtcg 1829341 tcctctgcaa tggaggcatg acattccggc ttcgatataa aactccctat tacagcttaa 1829401 aggttaaaac ttaattaaca atacgcacaa agtagcttct ttaatatagt acaccatcag 1829461 gcgcttttaa tcaagaggtc agaacaattg tttagaaaaa ctttttccag tgaataaaac 1829521 tgttttttct ccaaaatacc tgacaattcg acaaacaaaa aatatattac aataaaaaaa 1829581 atagccttta ttgctaaaag cgaatgatta ttttcttcta tattaatgtg tatatacaaa 1829641 aagactccta tttgtaacga taggagtctt ggctttatta gaattttgca gcaagatctt 1829701 ttgcttcttg taaacctttt tcaacgattt cttgcgcttg atcaggtgct gcgttatgtc 1829761 cttcgatgac aactgtgtgc aagtcttgaa caccccagaa accaagaact gttttcatga 1829821 agtttaatga catttcaagt gcagccattg gtccttctga gtagacaccg ccgcgagcgt 1829881 taagaagcgc aacttttttg ccgcccatta aaccgactgg tccttcttgt gtgtatttga 1829941 atgtaacgcc tgcgcgagac agataatcaa cataagtatg aagcactgct ggcactgtga 1830001 agttccaaag cgggaatgcg aaaacaactt tgtcagcttt tacaaactgg ttcagatatt 1830061 tgtcagcaat tgctgcttgt tttttctcat cttctgtcat ttccattcct tgacctgctt 1830121 taaatgttcc gttaatcata tctctgccaa ggtaaggaag gttttcctta tgaagatcta 1830181 attcaaccac ttcatcatta gggttgtttt ctttataagc agctaagaaa gcttcgtaaa 1830241 gtttagttga aacgccttct tcagctgtac ggtcgcttga ttttacaaat aaaactgtag 1830301 acatttgtat tcctcccggt aaacttttta tatttactta caaatagtat gttactttct 1830361 tttttacgta aagtcaatca ctttattttg aatatgagat tttttttcaa aaaaaagcaa 1830421 gtacatctaa tatcggtgta cttgcttggc atttttactt cgaatcttgt tcacgatcca 1830481 agatttcata cgtctgcgag cttttttgat caattgtttc tttgttggat aagtctttta 1830541 cctgttcatg aaactctctt tcataagaag gagcatctgt ctccagatca tcctccacat 1830601 cagcttgggc ctcaactgtc attcttgcat aaggaacagc ttcaagtctt tcgtaaggaa 1830661 tctcttggcc ggttttttca cacacgccat aagttccgtc tttcatcttt tgtaatgcac 1830721 ggttgacctc ctctaacagc tcccggtcaa tctctttcac tgtttggtct gtcatccggt 1830781 ctgtgacgag cgtcccgtgg tctgccatat ggttgtcaac cccattggaa agctccccca 1830841 cttcttccgt cattgattct gtttcctttt tctcgccaga caattctttt tgcatatcga 1830901 gcaatttatg atagagatgc tgtgtttgtt cttttgtcag tgccatgtat atcctctcct 1830961 ttctatcctg tttcccgttt tgccttctgt caaacatgga aacatcgatg gaaagatgag 1831021 ctactgcctt tttgaacgga tcgtgaccgc tggcgtcgat ggtgcttcgg gttttcgttg 1831081 gcactttttg tccttctctt ctggcggtat ataataggtt gcgcctatat ttaatctgcc 1831141 gctcagttca tcaatggtca gctcgccgaa ttcaagatga tagtcaactt tttcgacatt 1831201 cagcgtttca atatgtatat aggtttcttc agactcttgt ttgctgcttt gtttttgttt 1831261 ctcaatcact gagagtcttt cttcacattc acgcagtttg tcaagttctg gtttcaagca 1831321 atgcctgatc agcgaccgga acattttttt catgacatca cgaccctttg catactcctc 1831381 tttcgtctac atatataatg aggtatatcc catagaaagg agaggttttc atgcttccga 1831441 ctaacatcaa tatttctcat ctcaagacta actcgatagg caccggctca tcccttacct 1831501 ttggttctgc ggagttaagg aacaggtgct ctgctatcaa aagaaataac ggttttgggg 1831561 aacaaaatgc agatggtatt gttatggtca ttccgattga atcaattgat gaccgtgatg 1831621 tgtcagatgc actcagtatg aaaatcaatc atcaataaca atggttttcg cttgaccttc 1831681 gtctttttga atagtgatgt ataggattcc gtctttaaaa atggcattca tctttccatg 1831741 aagatgatcg gaaagcggaa ttttcttttc aaaacttccg tatttccctt ctttttggcg 1831801 aaagtcctgt tcattaaaat aggaaaagcg ctgccccttc accactaaat aatctccgta 1831861 cgataatatg tgaacgtctt gtttacggta gcctggaaga taaattaaaa actgcacttc 1831921 cgcaacggta tctacaatat ccatgctcgg aaatgaagca tctcctttcc ctcgctgatc 1831981 ttgctgcgca aacggaaacg gagattggcc atttgtcata aaaggggttt tttggtcttc 1832041 atcaaatacc tgtttccaaa agtcaccgcc gtacatctgc tgtgcgaatt ccatccactg 1832101 cttcatcttt tcgaaatcca tttgaagccc cctgtcttaa catactttat aaccgccagc 1832161 atacaactat agaaaggagg tttgcctgtg gttcaaccaa ctccgtatat caatattaat 1832221 attttcatgc tgaaaattaa ttcctttgaa aatgcttcag cggttaacgt aggacaaaat 1832281 ttattggcag aatggcaaaa ttcagataaa aaaaatcaag gctacggaca gaattttgga 1832341 gatgcgagcg gatttatggg cacgagaagc catgtggatg acagagacca aattgattct 1832401 ccggcctctt ttgaaagtga agcggttaac tcctcaatca aaaggaagtg atgagatgtt 1832461 cttttcaccc tccgtcgtaa atgtcggcgg atttaaaatc aatacgatgg atcgaggttc 1832521 ctctttaaca ctcggtccgt atcagcaggt cgattacttt ttatcagcta aaataaatca 1832581 agggtttgga gaagaaaatg gcgactttac tcctcttgtc gtgccgattt caaatgtatt 1832641 agatgcagat cttgttgatt cgaactcagc gaaaaacagt gtggtgtaat aagaacaggg 1832701 cgcacatgcc ctgttcttgt ttttatatat aaaaaaagcc taaccatttt ttgaacggct 1832761 ggctcatcaa atattcagct gcacaaatgc tttgtcagca ccgcctgaac ctcgcttaaa 1832821 tcggtgtctt tcgcaaattc taattcgaaa gttttgcttc ttgtcatcaa taaaagccca 1832881 gtgtccggat caaacattcc cgcttcttgg atggcaaagc tttcaattgt tttatatgga 1832941 agaaatacac gaaccttctt tttagaaaac attttattgt caaagaaaat gatccgctta 1833001 tttgtaaagc aaatttggtc cactcggagc ttataaatcg attcaattct ttccccttca 1833061 acgagcaaag cctcaagctt ctttgcgtcc gttgatctgc taacagaaaa aatacccaat 1833121 gaagaacccc tctttctgca tttatctatt tgttttatca ttcactacat aaaaataagt 1833181 cctttatccc tatataagaa tacgacatag aagacattta aaccattacg aacagattac 1833241 atttttcaaa tttttgattt gttttttggc ttttaagctg ttgtcatcaa gtaatacgca 1833301 catatagaga aaaaagtttc aatattcagc aatgttttta taaaaaagtg gtttttaatg 1833361 atttttttaa ttttgtttta tatttcctgt tttaaccaca aaaaaaccgc agctgagctg 1833421 cggttttatg tatcgactgc ttttaacaaa atctgtttga tgcttcaagg aagcattaca 1833481 tctcttcgaa gtattcttta taatagccgc cgactttatt cgtattgtcg accacaaaga 1833541 gaaactcctc tgtttcattt tttacttcat attcttttcc cggcgttaaa acgcggttta 1833601 cgatatattt ttttgcgttt gtctgcacac actttacttt tttaatggtt tctttttcaa 1833661 gccaattttt atgaatcatg atgaaatctc cttttcttat ctataagctt attgtagctt 1833721 ttttcttttg taaattgcaa tatcggttat tcattgattt tgccttgatt tctattatag 1833781 aatgtttgta tacgcttacg tttgaagcaa ctatcacagc ttatttctgc tattcaatcc 1833841 aggaatcaat gtgctatcac caagaatctc agaacagacc ataaaaaatg actggaggtt 1833901 tgttacggat gagttcttta acgatgcaag tgacgaaaag gctggagaca tttttacagg 1833961 gaacaaagaa gctttatatt gacggaaagt ttgttccgag tgcctcaggg gcaacctttg 1834021 acactccaaa cccggcgacc ggcgaaacct tgatgacgct gtatgaagcc caggctgcgg 1834081 atgtggacaa agctgttaaa gctgcccgga aagcctttga ccaaggtgaa tggagaacaa 1834141 tgtctccagc ttcgagaagc agactgatgt ataagctggc agacttaatg gaagagcata 1834201 aaactgagct tgctcagctt gaaacacttg ataatgggaa accgatcaat gaaacgacta 1834261 atggagatat tccgctggct attgagcata tgcgctatta cgccggctgg tgtacaaaaa 1834321 taacaggaca gacgattccg gtttccggcg cttattttaa ttatacgcgt catgagcctg 1834381 tcggtgtcgt cggccagatc attccatgga atttcccgct cctgatggcg atgtggaaaa 1834441 tgggcgcggc acttgcaaca ggctgtacaa tcgtcctcaa accggctgaa caaacaccgc 1834501 tttcagctct ttatttggca gaattaattg accaagccgg tttccctgcc ggtgtaatca 1834561 acatcatccc aggattcggt gaagatgcgg gagaagcgct gacgaaccac gaagcggttg 1834621 ataaaattgc ctttaccggt tccactgaaa tcggaaagaa aatcatgtcc accgcagcga 1834681 aaagcattaa gcgtgtgaca ttggagctgg gcggaaaatc gcctaatatt cttctgccgg 1834741 atgcgaattt aaaaaaagcc atcccgggcg ctttaaacgg tgtgatgttt aaccagggcc 1834801 aagtctgctg tgcgggctca cgtgtcttca ttcataaaga ccaatatgat gaagttgttg 1834861 atgaaatggc atcctatgct gagtcactcc gccaaggagc gggacttcat aaagatactc 1834921 aaatcgggcc tctcgtaagc aaggaacagc atgagcgcgt tctttcctat attcaaaaag 1834981 gaaaagatga aggagcaaaa gcagtgaccg gcggaagctg tccttttgaa gcaggatatt 1835041 ttgtcgcacc gactgtgttt gcgaatgttg aagacgaaat gaccatcgca aaagaagaaa 1835101 ttttcggacc cgtgctgact gcaattccgt acgaaacagt cgatgaagtt attgaacggg 1835161 caaaccattc agaatatggg cttgcagccg gactatggac agagaacgtc aagcaggctc 1835221 actatatcgc ggaccgactt caagccggaa ccgtttgggt caactgctat aatgtgtttg 1835281 acgcggcgtc tccatttggc ggttataaac agtcaggact cggacgagaa atgggatcat 1835341 atgccttgga taattacaca gaagtcaaaa gtgtatgggt aaaccttgaa gactaacatg 1835401 tatgtttaaa aaactgctgc ctgccagcag tttttttctt tctgtaatgg cagtaaaaga 1835461 cgctgaatat atatgcttct gaaggagttg agcgtgatgg gcacacttca ggagaaagtg 1835521 aggcgttttc aaaagaaaac cattaccgag ttaagagaca ggcaaaatgc tgatggttca 1835581 tggacatttt gctttgaagg accaatcatg acaaattcct tttttatttt gctccttacc 1835641 tcactagatg aaggcgaaaa tgaaaaagaa ctgatatcat cccttgcagc cggcattcat 1835701 gcaaaacagc agccagacgg cacatttatc aactatcccg atgaaacgcg cggaaatcta 1835761 acggctaccg tccaaggata tgtcgggatg ctggcttcag gatgttttca cagaactgag 1835821 ccgcacatga agaaagctga acaatttatc atctcacatg gcggtttgag acatgttcat 1835881 tttatgacaa aatggatgct tgccgcgaac gggctttatc cttggcctgc tttgtattta 1835941 ccattatcac tcatggcgct ccccccaaca ttgccgattc atttctatca gttcagctca 1836001 tatgcccgta ttcattttgc tcctatggct gtaacactca atcagcgatt tgtccttatt 1836061 aaccgcaata tttcatctct tcaccatctc gatccgcaca tgacaaaaaa tcctttcact 1836121 tggcttcggt ctgatgcttt cgaagaaaga gatctcacgt ctattttgtt acattggaaa 1836181 cgcgtttttc atgcaccatt tgcttttcag cagctgggcc tacagacagc taaaacgtat 1836241 atgctggacc ggattgaaaa agatggaaca ttatacagct atgcgagcgc aaccatatat 1836301 atggtttaca gccttctgtc acttggtgtg tcacgctatt ctcctattat caggagggcg 1836361 attaccggca ttaaatcact ggtgactaaa tgcaacggga ttccttatct ggaaaactct 1836421 acttcaactg tttgggatac agctttaata agctatgccc ttcaaaaaaa tggtgtgacc 1836481 gaaacggatg gctctgttac aaaagcagcc gactttttgc tagaacgcca gcataccaaa 1836541 atagcagatt ggtctgtcaa aaatccaaat tcagttcctg gcggctgggg gttttcaaac 1836601 attaatacaa ataaccctga ctgtgacgac actacagccg ttttaaaggc gattccccgc 1836661 aatcattctc ctgcagcatg ggagcggggg gtatcttggc ttttatcgat gcaaaacaat 1836721 gacggcggat tttctgcttt cgaaaaaaat gtgaaccatc cactgatccg ccttctgccg 1836781 cttgaatccg ccgaggacgc tgcagttgac ccttcaaccg ccgacctcac cggacgtgta 1836841 ctgcactttt taggcgagaa agttggcttc acagaaaaac atcaacatat tcaacgcgca 1836901 gtgaagtggc ttttcgaaca tcaggaacaa aatgggtctt ggtacggcag atggggtgtt 1836961 tgctacattt acggcacttg ggctgctctt actggtatgc atgcatgcgg ggttgaccga 1837021 aagcatcccg gtatacaaaa ggctctgcgt tggctcaaat ccatacaaaa tgatgacgga 1837081 agctggggag aatcctgcaa aagcgccgaa atcaaaacat atgtaccgct tcatagagga 1837141 accattgtac aaacggcctg ggctttagac gctttgctca catatgaaaa ttccgaacat 1837201 ccgtctgttg tgaaaggcat gcaatacctt accgacagca gttcgcatag cgccgatagc 1837261 ctcgcgtatc cagcagggat cggattgccg aagcaatttt atattcgcta tcacagttat 1837321 ccatatgtat tctctttgct ggctgtcggg aagtatttag attctattga aaaggagaca 1837381 gcaaatgaaa cgtgaatctt atcaagcgga gatgttcaat tggtgtgaag ccctgaaaga 1837441 tcagattcaa aagcgaggtc agcttgacca gtttgaagat caaatcgaca agatgattga 1837501 ggctctggaa gatgaccaaa caacagaaga agattggtat aaacaggccg ctgcccttta 1837561 tcgggatatt acagaatcag atgatacaag tgaaagacgc gcttatgtcc ctatagggaa 1837621 acacgtgctg ccaaagcttc cttacaaata ctccgcctta gaaccttata tatcacgcga 1837681 tattatgatc cttcatcata caaaacatca tcaaagctat gtcgatggcc tgaacaaagc 1837741 agaatcagag cttaaaaaag cgagagcgac aaagaattat gacttaatca ctcattggga 1837801 aagagagctt gcgttccatg gagcaggcca ttatttgcat agtatttttt ggttttctat 1837861 gcatccaaac ggaaaacggc gtcctacagg ggcattgttc caaatgatag acctttcatt 1837921 tggaagctat tccgctttta aagaacattt tacccaggcc tctaaaaaag tggaaggcgt 1837981 cggctgggcc attctggtct gggcacctcg atcaggacgg ctggagattt taacggcaga 1838041 aaaacaccag ctctttagcc aatgggatgt gatccccctt ttaccgcttg acgtatggga 1838101 gcatgcctac tatttgcaat acaaaaatga ccgggccagc tatgtcgatc actggtggaa 1838161 tgtcgtggat tggcgcgagg ctgaaaaacg ttttgagcag gcaaaagaag tcgtttggaa 1838221 gctctattaa aaaaagcccc ctttcctcgg gggcttcgtg tgttaaaaaa tacctatcac 1838281 atgcaaaaac acgatgatga tggcaacagg agatagatat cgaatgagca gcagccaaac 1838341 cgcaaaccac tttcgtttga gattggaacc gcttttcagc tcgtcaaaca aatcctgttt 1838401 cggtattttt agcggaacaa aaatcgaaat cagtaacgca cctaacggca ttaaaatatt 1838461 gctcacaaga tagtcagccg catcaaaaat agacagatga aatatagtga cgtcacttaa 1838521 gacaccgtat gataatgcag acggcacacc gacaataaaa atagcaatac cgcctaacca 1838581 agcgaatcgt tttctcttat tgatatcgcc tttcgacagt actgcgacca aaatttccag 1838641 cattgaaaaa gcagatgtca atgcagcaaa taaaaataga agtaaaaatg ctaataaaaa 1838701 gataattccg aacggcattt gattaaacac agtcggcaga acgttaaata acagaaccgg 1838761 gccttggtct ggcttgaggc cgaatgaaaa tacagctgga aaaatcgcaa ttccggccat 1838821 tacagcaaca agcatgttca taacagttac agatacagcg gactgtacca gattttcctg 1838881 tttctctaaa taagcgctat acgttaccat gacagataca ccgacactta ataagaaaaa 1838941 ggattgtccc attgcatata aaatggtatt ggcatcaatt gcagttaaat caggcatgag 1839001 gaaaaatttg attccttcca tcgcgccatc aagtgtaacc gaacgcacca ttaaaatgat 1839061 gaataataga aaaagcgccg gcattaatac ttggcttgct ttttcaattc cgctgcttac 1839121 cccttttgca acaactaaaa ttgttaccac cataaagagc agctggcctc ctacagccaa 1839181 ataaggattt gaaatggtac ttgcaaatat cgtatcaaaa ccagatgttt gcgataaacc 1839241 gccagtgaag ccttttataa tataaattaa aatccatccg cctacgacac tgtagaaaga 1839301 tagaagaata aagcacgtca ccatgcctaa ataaccgatc caatgccact tcgttcctgg 1839361 agcaagtgtt ttataggact gaacggcatc tttctgtgtt cttctgccta tgatgaattc 1839421 acctaacaat aaaggcagtc cgattaaaac cgtaaataaa ataaaaataa gtaaaaatgc 1839481 gcctcctccg ctggttccgg caacatatgg gaatttccat atcgcaccaa gcccgatagc 1839541 tgatcctgcc gcggctaaaa taaagccgag cttcgaagac cattgatttg cttccttcac 1839601 cgtatcactc ctatttgatc taaccattat aaaggttcat tgtaagaata tcttcctata 1839661 tagtcaagaa cattttaatt agtttacatc atatatctat agacatctgc caaaaactaa 1839721 tattgaatta ttcagaaaat tatttataat aagagaatgt tatgaaattt gtaagaattt 1839781 ctgctgaagt tcttgataag tgtgttagga gtgtttttat ggacatcatt agaaaaataa 1839841 gccattttgc aggacaaacc tttggcatat gggtcattgt ttttgcagtg ctgggatttt 1839901 ctttcccatc tttatttacg tggatcagtt cttatattac gatttttctc ggcattatca 1839961 tgtttgggat gggccttaca ctgcaagccg atgatttcaa agagctggtc agaaagcctt 1840021 ggcaagttat tattggagta atagctcagt atacgatcat gccgctcgtt gctttcggcc 1840081 tcgcatttgg gcttcatctt ccagctgaaa tcgcagttgg tgttattctt gtcggctgct 1840141 gtcccggggg aactgcatct aatgttatga cattcttagc aaaaggaaat actgcccttt 1840201 ctgttgcggt tacgacaatt tctaccttat tggcacctgt tgtaacaccg ttgttgatta 1840261 tgctgtttgc caaagaatgg cttcctgtct cgccggggtc tttgtttatc tcaatcttac 1840321 aggcggtttt atttccgatc attgcaggtc tgattgtcaa aatgtttttc agaaaacaag 1840381 tggcaaaagc cgtacatgcc cttccgcttg tttctgtcat tggcatcgtt gcgattgtct 1840441 cagctgtcgt cagcggcaat cgggaaaatc tgcttcaatc ggggttgctc attttttcag 1840501 ttgttatcct gcataacggt atcggttatt tactggggtt tctttgtgca aagcttttaa 1840561 aaatggatta cccgtctcaa aaagcgattg caatcgaagt cggcatgcaa aactccgggc 1840621 ttggggctgc acttgccacg gctcatttct caccgctatc tgccgtacca agcgcaatat 1840681 tcagtgtgtg gcataacctt tcaggttcta tgcttgcaac atattggtca aaaaaagtga 1840741 aaaagaagca agctggatcc aaaagcagca atctatcact ttaaatatgc atcaaaaagg 1840801 gtacatcact ttatcgtgat gtaccctttt ttattatcct tctaataaaa gctgttcagg 1840861 atcttccagt aaatttttga ttgtcacgag gaaaccaacc gcttctttac cgtctacaat 1840921 tcggtgatca taagataaag cgatatacat catcggacgg ttttcgaaac gctcttcatc 1840981 aatggctaca gggcgcagct gaatcttatg catgcccagt ataccgactt gcgggctgtt 1841041 taaaattgga gttgacatca atgaaccgaa agtccctccg tttgtaatcg tgaaggagcc 1841101 tccctgaagc tcgctaaggg ttaatttatt gtttcttgct tttttcgcaa gctcgccgat 1841161 ctctttttcg attcctgcaa atgtcaggcg atccgcatcc cgtacaaccg gaacgacaag 1841221 accttcatca gcagcaacag cgattccgat atcgtagaat tttttaacga tcaactcatc 1841281 gccttgaatt tctgcattca acagcggata ttttttcaat gcagccacga ccgctttcgt 1841341 gaagaaagac ataaagccga gcttcacttc attttgctca aaaaattgat ctttgcggcg 1841401 ttttctgaga ttcatgacag ccgtcatgtc cacttcatta aatgtagtca gcatcgctga 1841461 tgtttgctgt acctctacaa ggcgttttgc aatcgtttgt ctgcggcgtg acattttttg 1841521 cacttcaaca ggtttgtcaa agctttgctg tgctttttga gcctgaggct gctgcttttg 1841581 ctgaggagcc ggttttgatg ccggtttttc gtacgcttcg acatcctgct tgcgcactct 1841641 tccaagcgga tctccagttg gaacttgaga caggtcaatt cctttttctc tcgcaagctt 1841701 acgggccgac ggagaagcga tcgttcttga ttttgcttca gattgtgctt cctcgctcac 1841761 ctcttgtgca gctggttcag cctgtttctc ttcttttacg ctttccttgc tttctgtttt 1841821 ctctgtagga gcaggggcag aactttcacc cgcgccttct gaaatcgtac cgataatttc 1841881 tccgacctgg acggtatcac ccgaatcttt caatacctct tgaagtacac ccgattcttc 1841941 tgctgtcaat tcaacattca ctttatccgt ttctagttca agcagatatt caccctgttc 1842001 tacatagtca ccaggctgct ttaaccattg ggctattgtt ccttctgaga ttgattctgc 1842061 taattcaggt accttaattt ccgccatttt ttcatttccc ccttagtttt tgcgagtcaa 1842121 gctatcagat acaatacgtt cctgttcttt tttatgaact gtcggatctc cctctgcagg 1842181 gctggatcgt cttcttcgtc caatatattg aacgcttact ccctctggtg caatctctgt 1842241 caaatacggg ctgatataac cccaagcccc catgttctgc ggctcttcct gcacccaaac 1842301 gatttctttc aggttcggaa gttttgcaaa taattctttg actccttttg ccgggaatgg 1842361 atacagctgt tcgattctcg caatgtgaag ccactcttta ccgtcttcta acttattaaa 1842421 atgatcgcta atgtctatag acactttacc gctggataat acaagtctgg ttactttttc 1842481 atagtcatga gaaagtcccg actgttcata aacaggctgg aagcggcttt cgctgagctc 1842541 ctgcacttcc gacaccgtat ttgggttgcg aagaaggctc ttcggcgtca taatgacgag 1842601 cggtctgatt tcttcacgaa gcagcatttt agcctgtctt cttaaaatat ggaaatactg 1842661 tgccgcgctt gtcaggttgg caaccgtcca gttgttttcc gctgcaagct gcaggaatcg 1842721 ctcaattctt ccgcttgagt gctcaggccc ctgtccctcg taaccgtgcg ggagcagcat 1842781 gactaatccg gatttttggc cccatttcgc gcgtccggca gaaataaatt ggtcaaaata 1842841 cacttgagca gcgttggcaa aatctccgta ctgtgcttcc cacaaaacaa gcgtttccgg 1842901 tgaatgcacg ttatagccgt attcaaaacc gagaaccgat ccttcagaca gcgggctgtt 1842961 atgaacagca aatgatgtgc tgcagtcaga taagtgatga agcggcacaa attctttgcc 1843021 cgtctcactg tcatgaagca caaggtttct ttgggcgaac gttccgcgct cggaatcctg 1843081 tcctgttaaa cgaatcggtg ttccgtcttt caaaattgaa gcaaacgcga gtgattctgc 1843141 caaagaccat tccacttttc tgtcatcatc gaacgccttg gcgcgtcttt ctaaaatgcg 1843201 ctttagcttg ccgaaaacat taaatgactc cggccagttg atcaattcgc cattcagctt 1843261 gcggagcaca tcaaaatcaa tcgaagtgtc cacatctggg aaaccgtttg atacaggctc 1843321 tggaagttca atttcacaag cagtgtgttc ctttttagac ggaactttct gatatgcatc 1843381 ctcaatgcgc ttcgttaccg atttttcgat gttttgaacg acttcctcgg taaccacgcc 1843441 ttcttttacc agcttttcag cgaaaatttg tttgacggtc ggatgctttc tgacagcatc 1843501 atacagcatt ggctgagtgg ttgacggttc atccatttcg ttgtgtccat agcgtctgta 1843561 cccgatcaaa tcaatcagaa aatccttgtt gaatgttttt cggtattcga ccgcaaactt 1843621 aacagctgaa agacaagctt caggatcgtc cgcattcacg tgaacaatcg gaatttcata 1843681 acccttggcc aggtcgctgg catattttgt cgatctggat tcagcgcttt ctgttgtgaa 1843741 tccgatcatg ttattggcga taatatgaat cgcaccgcct acttgatacc cttttaaaga 1843801 gcttaaattc aatgtttcag ctacaattcc ttccccaggg aatgcagcgt ctccatggat 1843861 taaaatggcc agcgattttg tttcatcttg taccgggtat ccgctttgtg ttcgcgtttc 1843921 ctgtgccgct cttgtgctgc cttcaacaat cggattgata aattccaagt ggctcgggtt 1843981 gttcgctaac gtaatgcgcg ctgattttgt ttcagcgtct tgaagctccc gattcgcccc 1844041 caaatggtat ttgacatccc ccgtccatcc gtagctgatt ccaatggatc cctcagacgg 1844101 tacaagatct ttgttcggcg catgctggaa ttcagagaag atgatttcat acggtttgcc 1844161 gagcacatgt gccaagacat tcaggcgtcc cctgtgcgcc atcccgatgt tgacacttgt 1844221 cgtgcctgat ttgacagatt gtgcaataat gtcatcaagc actggaacaa gagcgtccag 1844281 accctcaatg gaaaagcgct tctgcccgac gaatgtgcgg tgcaaaaact gctcaaagcc 1844341 ctctacttct gtcaatcttt ccagcacagc tgacagcttt tcagctgagt tcttctggaa 1844401 cagctcgcca gattcaatct ttcttgtcag ccactcgcgc tctttgaagt catgcacatg 1844461 gtcaaattca aaagagatgg ttcttttata cgtatttcgt aaatactgaa tggcttctaa 1844521 accgttcgaa atgtttttag gagcgtcttt gcagatgaca gacgcaggta ttgcttttat 1844581 ttcctcttct gttagcccgt aatcggataa tggaaaaagt tcgctctttt tctcatcctt 1844641 tctgagcgga ttgacggaag cgttcaaatg gccataggtt cggatatctt ctgcaagtct 1844701 gactgcggat gcgatctttt gaatcagatc ggctgtaaca cgtccctttt cttttgttcc 1844761 cgaggcctct tttatatcgc ttggcggagc accgagctcg tcgaacattt ccttcaaatc 1844821 cgggtcaatg ctgttcggat cctgggtata ctgatcgtaa agctccagcg catagccgag 1844881 gttcggaccg taaaaatctt cccaattcat tcgttgtttc atactatttt gaaacatttg 1844941 aatattaccc ccaacttaaa taatcaagtg attgattcac tatcttgaaa taactttcga 1845001 acgctgtgtc caaaattatg taataaaaac gcttccaacg atattttacc actgtttgca 1845061 atttgattct accttgattg ttcacaaaat agtaaaaaac ctttataaaa aacaaaaaat 1845121 ttaatcattc gaaaaaacaa acgccaaaaa gcataggatt aagggctatc ctatgctttt 1845181 atgaagcagt tttttcagca gcggatacaa aacatccggt agctgatcaa catccgggac 1845241 aaatatactg aattttccgt acatatcctg gatcgtcttc atttgcgatt cttctatttc 1845301 tgagttggag agaaaaacat ttatcacttc tattcctctt tttcgggctt cgataaccgc 1845361 ctcacttgta tcaacgatcc cattttgttc gtagccaaat gcggccggct ctccatctga 1845421 gaaaacaatt aagaactttt gcgcctcgct gcgatgcagc atttttttcg tcatctgcct 1845481 aattgcgtac ccgtcacggt tatcttcttc tggctcaagc tgcataatgg ccggtccaga 1845541 atcttgtctt aatgatgatt ggaagggaat aaccgtattg aaatagtttg gctggctttt 1845601 ttcggttgca tcatttgtgt cctcccaaaa accgacaatc tgatgcggaa ccgctaccga 1845661 tttcaacgct tcgtgaaaca gcacgattcc tcgttttgtt tcgtccattt tgtcgaacat 1845721 gctggcggaa caatcgacca gcaatgtaaa aactgcgtcg atttctgaag atggttcttg 1845781 ctttttgtag aacaggcgcg gatttcgctc agtgaagtaa cgaagaagct tattgttcag 1845841 tctcccggca tgaaggtctg ttctcggcaa tgttttttta tgctccagcg ttttttgaat 1845901 catttgtttc aaacgctttt gatacgattc aatcgttttt gcctgctgtt tataagaaag 1845961 ctcttcttca ctggttgccg gctgcggttc tttataaatt ggaaatgcat atttattttc 1846021 tttgccgtca gccatacccg ctccgttcgg ctggtctttt tgggactcca gcgcttccag 1846081 cttggaatag tctttccgtt tcgtttgtct ggctgatcct tgaacagagc caagggcctg 1846141 atctccatcg tcgccttccc ttgaagcatc ttttcctaaa tctgattttg cgccgtgttc 1846201 aatatcaaat tgaaggaagc ttttagacgg tgcttctgtt tcccggtgcc atgtcggcat 1846261 ttcttcttca tggatatcct catcaccgtc tgattgtttt ggaagcgtga tgtcatcact 1846321 cagcttcggc gcttttttct cttcttcaaa taacggctgt tctgcagctt ttgcgtaatc 1846381 aagctcaggc aaaaagaagt aggtgttcaa catgtcttta tcgagtacct cttcaagtcc 1846441 gtccatgagg tcctcaacaa ttttcagaac ctgccgtgtc gaatctgctt catacacacg 1846501 caagagctgc tgctcaataa acgggcgcat cagatcgata tcttcacgca tggatggaag 1846561 ggtctcgagc ggcgattccg ctgtgagctt gaaatagatc gcgcaaaaga gcgcatcggt 1846621 aaaaatgctt cgttccaaat ttaaggtcag ctgggttgag aaatgttttc tgtacatgtc 1846681 ttttcgcttc gcaaatacat gtttcgtacc cgggcgctca cgtttgatgc attcttcgat 1846741 cctaatgtct tcaagcagca taaagagctg cttggcaaaa cttttaaacg taagatggcg 1846801 atggatatca ttcaaaaagt tcgcaaactc atgcagcgag ctatatcttg ttccgactga 1846861 acgcaggtag acgtcgcttt tcagacccgc ttccatgtcc tcagctgccc tgtctttcca 1846921 aaagtggctc atatagattt tcttttcaaa tggattgtaa taggactgaa cgccatactc 1846981 cacttctacc gcttcactct tggtgagtgt tttggccaaa tcagtcagca tcataaataa 1847041 aaatgaatca atcgtgctgt cgttaaattt gataaatttc atcgcagccc cctcattcaa 1847101 acagagtttc tgcaatattt cggacagccg ctttttcccg atcatcatca agcttttcta 1847161 caattccccg ctcaatggca cgacgcggcg gaatataagc agctaaatca catgtatcga 1847221 ttaaagctct gatggatgcc gcttcttcag acacctgtcc gttattggcc tgaacgatca 1847281 agtcagagga aagcgtgata aatctgtcaa tcaatttctc gtctttcaag gctgactgag 1847341 acatgagcac ttgtttcagc agctcgcctt taatataagg cacatcaatg atgacaaaac 1847401 ggtttttcaa cgcttcattc agaggaacag ttccgacata gccttcattg atggctgcaa 1847461 tgactccgaa accgctttta gcccgtatga cctcgcctgt aaacggattt gtcatcattt 1847521 ttctgtaatc taatacaccg tttagaatag gcagtgtttc cggcttcgcc atattgattt 1847581 catctatata aagaaaatgg ccttccttca ttgcctttgt aacaggtcct gaaacaaact 1847641 cgattgttgc ctggccagat tgattttcaa tcgttttata accgaccaat gcctcagcgt 1847701 ccaagtcgac tgaacagttg acgctgtgca tcggtttatg aaaatagctg gacaatgttt 1847761 ctgccagctt tgtttttcct gaacctgtag gccctttcag caggacattt ttccccatgg 1847821 ctaatgcaat aatggcgtca aataaaatgg cttcatcctc cgcctcatag cctgatgttc 1847881 ctataagcga ttgaaactct ggggaaatag gctgctcttt atatgataaa agcttttgtt 1847941 gtatatcttc cggcaatgtt aagtgctgta gttgagttgt catagacaga ttccctttcc 1848001 tattcatatt ccattaacga gtatactaaa aaagcccctg tatgctcaat acaaaagggc 1848061 ctggatgata ttactgcttc tcgttatttc ccaaaagggc tccgcagaca atacgcgcac 1848121 cggaattgcc gcttgggttt gtcagataat cgtccgcttg ttcatgaata ataaatgcac 1848181 ttccgtcctc gtcgagaata tttagtttac ttcctttttt cagtgaagtg tcaggcgcat 1848241 tcattatgac atctaccttt ccatcagcac cgacttcaag gttcggcaga tctccggcat 1848301 gatgccccat cggattatta aagccgtgtt ctttgttcag tggattaaag ggaccgcccg 1848361 ctgattcaaa atccggcctg acacaagaac ctttctcata aatatgaaaa ccgagagaag 1848421 cacctggacg caggctgttt gcggaaatat gaatatcgag gccttcatca tctgattctt 1848481 tgatctctat aaaaccgact gctttccctt cacgattgac cagctggaca tgatgaccaa 1848541 acgctgacgt ttcaaccact tttttttccg gcacccggtt aggagggtct ggaggttttt 1848601 tttgtccgca tccggcaact cccagtgccg tcagcatcat caacagcaag agacggtgca 1848661 tactgtctcc cccttgtttt ttctaacagt gtggtcaatc attgtctggt ataaacaaaa 1848721 aagcctataa aaggcttttt gtcatactca tttttaaaaa taacttcttg cgcccaagta 1848781 ccgctgtttc caatacgaat tgctgagatt ggaaatgtcg acgcccgatg agcttgcatg 1848841 aataaaatca ccgccgccta gataaatccc catgtgagac gggccggatt tatatgtggt 1848901 aaagaagaca aagtctccta ctgacggctg gctgactttc tgcatgacat tccaataccc 1848961 tgccgtactc aatcttgata tagatgatac attattaatg aggtaataaa tgaagccgct 1849021 gcaatcaaaa ccggcaggcg tgtttccgcc ccatcggtaa ggcactccga catatttttt 1849081 cgcttccgtt atcattctgt caatcttcga acctatttga atgtttgacc ctgagttatc 1849141 ttttggcttt gttggctttg tcggatttga aggattagat tttgatgctc ccgaaatagt 1849201 cagaacctgc ccgatttgca acacatccga tgataaattg tttttatcac ggatgctttg 1849261 gacagtgact ccgagccgat ttgcaatttt ccacagcgaa tcgcctgctt ttaccttgta 1849321 cgtcgttgtt tttgagggat tggagtttga cggctttttg gaaccgctgt ttccgttctt 1849381 aggtgaactg cttcctttta ttttgagcac ctgtttagga taaagtgtat ctgatgttaa 1849441 gccatttaag gtttttaatt cggctacagt catatttaag ctgtttgcga ttttccacag 1849501 tgagtcacca agcttgaccg tatatgtact ttttgaagaa cctgaagaat tggaaccgct 1849561 gtttttcttt gatccatttg atccgcttga actgcttgtc cctttgatct taagcttttg 1849621 ccccggacga atcaggtcac tgctcaggct gtttaagctt ttaagctcag aaacactcat 1849681 tttatgattt ttagcaatca tccataggga atcaccatat gcaactgtgt atgttgatgt 1849741 tttgcttgaa ttagatgggg atgtcgtgct ttttttgctg ctttcaggaa ccttaagact 1849801 ttgtccgaca taaagcaccg ttgatttcaa tttgttttcg gatttcagag ctgatattgt 1849861 cgtatcatac tggcgggaaa gtttccaaag agagtcaccg ctttttactt ttatcgtttt 1849921 tgcttccgcg ggtgctgcgg ccatcgacga cccaacaact gcagaaacag ccaagccggc 1849981 tacaatcttc tttttcattc attcaacctc ctaaactgtt tttttgcaaa aacagctagt 1850041 attttgtttc caaaaatggc acacaactgt tttatcgtca atttttcagc aagttaaacc 1850101 cttttcaaac atttggcgca gcattttcag catcgttcga cctttaaacc ttcaaataaa 1850161 catctaacat tttacataag cacgatatgt ttttcgaaag tctaaggaac tatttaagcg 1850221 agggtaaaaa tgatggtttt ctattgatga acgaagcagt ttctcctcct ttcttgtcta 1850281 tttttctaat caattctcta tcggcgtgtc aaatcccttc ctctgcattc ttatgaaatg 1850341 gcaaaaagcc tgttctttcg ataagaacag gcttttacac tatgcatttg ctgattgagt 1850401 tttttgtttt acagcttcaa gaatgctgtc ggctgctttt ttagagccgc ctgccgcttt 1850461 cagtgattgt ccaatttctt ttgccttttc agcatacgaa cgattattca ttacttcttg 1850521 tatcgtctct ttcagtaggc tttcagacaa ttcttccttt ttaattactt ttcctgcgcc 1850581 gactttttct acctgatctg cgacaacaaa ttggtcgcct cccatcggaa tgacaacgag 1850641 cggggtttca aaatacaaac cttcacttgt gctgttcatt ccgccgtggg tcacaaataa 1850701 gctggctctt ttcaagatct caagctgagg gacatacggg cgtacaatga aattctccgg 1850761 aatgtcgttt aactcacttg ttttaatatg cttgccgatg gaaagcacaa ctttaccgtc 1850821 aaagtcctta cacacttcaa ggcattgatt aaaaaactgc ttttgattat taaaaatggt 1850881 tcccattgaa ataaacagca cgttttcatt gtcaatctga tcaaatggga aatcattgtt 1850941 tccggctctt tctgtaatgg aaggaccgac aaatacatat cgctcgccaa attgctcagc 1851001 cagtggctga aatccccttg atgtaaagac gattgtcaag tcaccatcag ctaaaaaaac 1851061 atcaaatggc ttcttgatct ctgcttgaaa atcagcattt aacgtttctg caagctgctg 1851121 gtatgattca taatgaggcg aatcttcaag tgatcctttc atgtacgctc ccatcatttc 1851181 cttcgcaaat tcctcattca tcgcaaaggt tgtacacaat gaaaatcttg gcagcttcag 1851241 catgttggca atgactttac ccgcgagaag atggtgatca tatatgacat aatcatacga 1851301 ttcatgtttg acttcctcat aaatatgagt cgcgatatcc ttacaggctt tcaaaaaagc 1851361 gcagagcatt tctgtgaaat ctctttcttc atcgccggtt gcgtttttcc cgaagtaatc 1851421 tcctctgaaa tcatgatact cacgaaactc tatatcaaga gctgtgattt tttctttata 1851481 ttccttcact gcgtagtacg taatgttttc tccccgggat ttcagctcct tcatcacacc 1851541 gatagaggga ttaatatgcc cttcaccggg gaaaccgatc attaatacat tagccatgcg 1851601 gcagcaccct tcctttgaga atttatgtaa tattttatac ggtactataa atgcataaac 1851661 aggtaaagta tttcacttaa ttaatattca tcatatataa cttttctacc agtttatatt 1851721 ccctgtcttc aagacaaaaa gcattcagct tgaagcgaat gctttaataa agatgcgaat 1851781 tcagtcattt tgtctcatga taggattctt aatcaggccc tttttattat ttttacgttc 1851841 ttggtgaaat taacggatat aatacaccgt ctttggcaaa cgacatcttc cctgtttcct 1851901 ctgaaaccac gagcaccagt gcatccgtat agcccgacat accaagagcc gcccggtgcc 1851961 gggttcccaa atggatatcc acttccttcg tcgtcagcgg gagcacattg gctgctgaca 1852021 cgagtttgtt ttccctcact aataaagcgc cgtcatgaag agggtttccg ggaaaaaaga 1852081 tgctttcaat taatgaagag ctgatctcgg cgtgtaggga ggtgcctttt tgaataaaac 1852141 gttcaaccgg gtctgctctt tcaatcacaa ttaaagctcc atgcttatgt tccgataagg 1852201 ctttaatcgc cttggccagc tcaataaatg ccggcgtaaa ttcctcaatg tatgattgca 1852261 aataaaagga ggatgcaatc ccctgcatgt cctgaaaaac gtgccccaaa tcatctaatt 1852321 cacaaaggag acactggtct ttttcgtgaa gcgttttcaa gattagagat gcatcaccta 1852381 atatttgctc taagtacacc tgtattttcc ccttgaacgc attttctgat atctgctcat 1852441 agcgcatagc cttcatctcc tgtttaaatt tccaactttt cacgaatgct tatcttattg 1852501 atgcacattc tattggtaaa ggagggatgt aaagaatgga aatcgaaaga atcattcagt 1852561 atatttgcac ctttttaggc gtgatttcgc tttcttttat ttatgcccaa atgtttagaa 1852621 aaacgaaacc gacaaaaaaa gaataggccc ggcgttcatt gctttttata cataaaatgt 1852681 tataatttct ctcgttatga aaaagaaacg gagatcaatg tatgaaagaa actcaaaacg 1852741 cccgggaaaa aatcaaacag ctcttgcaca ttttaatacc gatattcatt acccaagcgg 1852801 ggctttctct gatcactttt ctagatactg tgatgtcagg gaaagtcagc cccgctgatt 1852861 tagctggtgt cgccattggc tcaagccttt ggacccctgt ttacacagga cttgcaggta 1852921 tattaatggc ggtcaccccg attgtcgctc agttattagg tgcagagaaa aaacagaaga 1852981 ttccctttac tgttttacaa gctgtatacg tggccgcgct tcttagcatc gccgttttag 1853041 tgattggata tgctgcagtt gaccttattc ttggccgatt gaaccttgat attcacgtgc 1853101 atcagattgc taaacacttt ttaggctttt tatcactggg aattttccct ttatttgttt 1853161 acaccgtgtt gagatcattc atcgactcat taggaaaaac gagagtcacc atgatgatta 1853221 cactcagttc tcttccaatc aattttgtat tgaattatgt atttatcttc gggaagttcg 1853281 gaatgccggc acttggaggt gtaggcgcgg gactggcatc cgcgttaact tactggtgta 1853341 tatgcatcat cagttttttc attattcata aaaacgcacc gttttctgaa tacgggattt 1853401 ttcttaccat gtataagttc tcttggaaag catgcaaaaa tttgctcaaa atcgggctgc 1853461 ctattgggtt cgccgtgttt tttgaaacga gcattttcgc agctgtcacg cttctcatga 1853521 gccattttca tacagtgacc atcgcgtccc accaggcagc catgaatttt gcgtctcttt 1853581 tatatatgct gccgcttagc gtgtccatgg ctctaacaat tgttgtcgga tttgaagcgg 1853641 gtgcagcccg ttttaaggat gcacgctcat atagcttaat cggcatcatg atggcgatcg 1853701 gcttttcttt gttcactgcc gcctgtatcc ttttattcag agagcaaatt gcgggcatgt 1853761 acacttctga ccccgatgtg ctccggctga cacagcactt tttaatttat gcgctatttt 1853821 ttcagctttc cgatgctgtt gccgcaccga tccagggagc actcagaggg tacaaagatg 1853881 tgaactatac gcttgcggcc gcttttgtct cttactgggt cattggcctt ccggtcggtt 1853941 atatggtcgg tacgtttaca agcctcggtg cattcggcta ttggattgga ttaatagcgg 1854001 gactcgccgc cggagcagtt gggctgtttt tcaggctggc aaaactgcaa aaacgttatt 1854061 cgcaaaaaca acacatttaa aagaggtgat caatcatggc aaaaaacaaa aaattattcg 1854121 agtatctttc ccagcatgcg gaaaccatca gttcaacatg gtatgaaaca atcgaggaga 1854181 ctgatcccaa ttccatttat gcctcaacag accctgttgt cattcacaat ttaaagagcc 1854241 agaatcttgc ctttaactat aaaataaacc gtatttttat agatgatgag gacgtatact 1854301 tgcctatact gaaagaatgg gcctttgaag tcacacagga tcaagagcat ttaaaaactc 1854361 ctatccacta tattattcgg gagtttgtca gagtgagaga tttatatgtt tcttatgtga 1854421 aagaatttgt ccatctcaat cagaatactg tgaaaagcga agaagccgaa gacctgtatc 1854481 acgcccttat aaaagcgttt gatcttgtga ttcatatttt tatagaagaa atgtacaaaa 1854541 acacaagcct tcagcttcag gcccaaaaag atatgattac tgaattgagc gctccggtca 1854601 tcgtgctgtt tcacagcgtc ggactgctgc ctttaatcgg agatattgat acagtccgcg 1854661 ccaagctgat tatggaaaac acactgcatc aatgtgcgaa aaaaaaggtg acacaactgt 1854721 atattgattt gtcaggagta gctgtgattg atacgatggt tgcccatcag ctgttcagtc 1854781 tgattgaggc gcttcgttta atcggtgttt cttcaacttt gtctggaatc cgtccggaaa 1854841 tcgcgcaaac agcggttcag ctaggtttgt ctttcgaagg tatttccttg agatccactc 1854901 tcgcttcagc tattgcatcg gacttaaaat taaaaaaggt ataaggctta aggccttata 1854961 cctttttgat taatcattcc attgatacgt ccaatatatt tcttcttcaa accatgttgc 1855021 cataacaggt tcattatttt tcaatttctc ttcaagctct ctgagcatgc cttctgtttg 1855081 tgtgcggtga gctcttaacg cattcatttt aatatcagct acttctttga tatcaagtac 1855141 gacatcagct tcgccgagaa cctcttctct gttgcgggta atggccatgc agattgtacg 1855201 cggacggtct tctttctttt tgcggtataa tgcacggata accgcttccc cgcatgcatc 1855261 atggtcaggg tgcacaccgt gtccgggata aaatgtgaca attaaacttg gttttacatc 1855321 atctatgatc tcttccatga tatcagctaa atactcatcg tcttcaaatt cgagcgtttt 1855381 gtcacggagt ccaagcatcc gaaggtcatt gatatccatt tctttgcaag cgttgatgag 1855441 ctcttgtttt cttagcagcg gcaacgtttc ccgattcgcg aaaaatggat cgcccatatt 1855501 tctgcccatt tcacctaaag tggcgcaggc atacgtaacg ggaatgtctt tttttctgtt 1855561 taaggcaatg aggcctgcca ctccatatga ttcatcatca gggtgaggca ggattactag 1855621 tacatgttct ttcattatta ttcacccttt tctttaaact gtgaacggtt tttcgctgat 1855681 ttgcagagaa atagccagtt taccgcccgg caggtgtccc gccattaata aacggttttc 1855741 ttcatctacc gtgtattcag tcaagccttc agcataaatc cagccttctt ctgttttcaa 1855801 gccaacgcgg taaggcccgt tgcctttgat ttttgcctga tgataagtga cttttgcatt 1855861 gcgaatatac gcaacaaccg tcatgttctt ttcatttaag tgcgctgaat aagaacctgt 1855921 ggtggtttct aaatggatat atacagggcg gtccgcatat cgttctaaag atgcttgcac 1855981 atcttctttt atgatcgctt tcatgattgc tcccctcttt cttcttttaa atactctgca 1856041 cgttctgtat gtaatttgac cagctgatat ttcacagccg gttcgagctg tgaattcaca 1856101 atgcgctgaa tcgcggcaaa atatttttcc agcatcggtt ttcggagtct tggatgtgtt 1856161 cgtttatcca agagctcaag atcaatcgcc tctgctaccg cttctgcgtc atcatgtgcg 1856221 agagatcggt tattccaaag tgaagcatag gctttcacta tctctttatc attgtccatc 1856281 gtcttgctcc tttatgtctt acatacatga aatgattata cataatatat gcatcagctg 1856341 aaaagccaaa ggcctcaatg gctttttgac gcccgtttcc acttcacttg tgaaaacgta 1856401 aacaagagca gcgcagccca tatacagctg aatgtaaaag ccttcgagct tgaaaatggc 1856461 tcatggtaaa caaacagccc gatcagcagg gtaatggtcg gcgcaatata ttgtaagata 1856521 ccgacttgat acagtggcag ccgtttcgct ccttccgcaa acaataagag cggcaaagcc 1856581 gtaaacacac cggccaaaaa gagaagcagc cacgtccctc cgctttctgc acccgctggc 1856641 tgaacatgtc cgctgaacag caaatacccc aatgcaatgg gcataatcat gaatgtttcc 1856701 agcgttaaac cgatggcgct cggcaggctt gttctttttt tgcttaaccc gtacagccca 1856761 aagctgaatg cgagcagaag cgcaacataa ggaatggagc cgtattggaa cgccgagatg 1856821 atgacaccgg ctgccgcaat cgaaacggcc actaattgca ggcgattcag tttttccttt 1856881 aaaaataaaa tcccaaggag cactgataca agcggattaa tgtaatagcc aagactagcc 1856941 tcaagcaaaa agccatggtt gacagcccat atgtatacaa accagttgat cgaaatcagg 1857001 atagaagcaa gaaataaaga gaggatccct ccgttctttt tcagagagcg caactcctgc 1857061 catcctattt tccattgccg caagaaaaaa agtacgatac acataaaaac aaaagaccat 1857121 ataatacgat gagccaaaat atcaagagcc ggcagctgtt cgagaagctt ccaatagagc 1857181 ggaaacaggc cccacatgat aaatgaaacg gctgtgtaaa taacgccttt ttttgtttct 1857241 gcatgttgca ttgatatccc tgcctttctt tagagcatct tatattatat cacgtgaaag 1857301 atctggtggg catatactat tttgtccgtg aagaaaggat gtgaagacaa tgtttgagtg 1857361 gaacaagtac tttcctttcc acaatcaatt ttctaaagaa gcattaaaaa aagctgatcc 1857421 gaaagaagtt gaaacgtatg tcaatcgtgt gatggaaagt gtgttcggca gtgattatgc 1857481 ggctcaattt cctttccgcg atcctctccc ccaaaaagaa catcccgcca aacctgatgc 1857541 aaaacctgat gtcaaacctg atattgatat attcgaaaca gcagaccatg tgtttgtaaa 1857601 ggtgccaatc agcgaagaat ggctggaaca agtgagaatc aaacacacat ctcacgaatt 1857661 atggttggaa aacctcccaa gagcagatca tccgaaaaaa gtaaaccttc cttgtttagt 1857721 caaacgcaaa ggaacaaaag ccgtctataa ggatggcctt ctggaagtca tgtttcaaaa 1857781 gcagcaagac tacaatatgt ccgaggtaga aatcatccga taaaaaacgg cctgcaatcg 1857841 atgcaggccg ttttttatta atagaagccg ggatatcccc cgtatggcac gccggcacca 1857901 aaaccgtacg gtccgcctcc atatccataa gggccaggag gataggcata gggacgagaa 1857961 tagttaaaca gcgcactccc gagaaaaccg cctaataaac cgccgactag aggagcgcca 1858021 aacaaaaaag gactacgcgc cggatatccg gctggacctg ggattccgcg taaatacgaa 1858081 tgatgagggt acatgatttt ttcctccttt atgtctgcct atacgtaaag tattcagcaa 1858141 ggaagaaaaa cgattgggct acggactgtc tatgattgtt acatcacaag ccctgccaat 1858201 aacacacagc cgagccctgt aaccgaaaga actgttgtaa gcagcgtcca ggtttgaaat 1858261 gtttctttca tgctcaagcc gaaaaattcc tttaccatcc aaaatcctgc atcatttaca 1858321 tgacacgcaa tgacactgcc ggctcctgtt gcaagcacca ttaacgcagg gtttacactg 1858381 ccagcctcca taagcggagc tgccattccc gctgtggtaa gcgcagccac ggtagcagag 1858441 cctagacaca gacgcagaac cgcggcgatg gtccatgcaa cgaatagcgg cgacatgttt 1858501 gtttgacgga aaaaatcagc gacataatcg ccgactccgc cgtcaatcag cacctgttta 1858561 aacgctcctc cccctcctat gatgagcagc atcatcgcaa tttgcgaaat tgattctgaa 1858621 atagatctgc cgatttcctg catagatatt ttacgggcat atcccatcgt atagagtgca 1858681 agcaacagcg aaatgagcat tgccgttccc ggagtgccga taaattctat aatgtctttt 1858741 ccttttgaat gttcactcaa taataaagaa aaaattgttg ccattgccat aaagataacc 1858801 gggaataaag acgtgacagc actgatcgca aagcccggtg tttcatccag ctgaaattct 1858861 ttccttggtc ctaaccccga taggtttcca tgcttttgat acgcaccagg aaaccgtttc 1858921 atcgcaaatt tattaaataa aggcccggca atcacagttg tcggaacagc gatgatgatt 1858981 ccaaaaagca gcacctggcc aatatgggca ccatatgcaa ctgagatagc agttggagca 1859041 ggatgcgggg gcaaaaatcc gtgagtaaca tttaaggcgg cggccatcgg gattcccaga 1859101 tacagaaaag gcatttttaa ttctttagca atcgcgtaaa caatcggtat caacagaaca 1859161 agaccgactt caaaaaatag ggcaatcccg atgataaaag aggcaaccac aaccgccgcc 1859221 tgtattcgtt tcctcccgaa tttgtcaatc agcgtaatgg cgatccggta gccgccccca 1859281 gcatctgaga caagcctccc aagcatcgcg ccaagtccaa acactaaagc taaatgcccc 1859341 agctgcccgc caattccagt ctcaattgaa agaacaattt tattgatatc cattccaagt 1859401 ccgatggcta ctaaaaatga aacgacaatc agtgagacaa aggtatttaa ttttacttta 1859461 ataatgagaa ataacagaat cagcactccg acagctacaa ttaaaatcgg catggtaccc 1859521 ctccaaaagt gttttatatg attctcgcga caatgttttg gcgcttttca tgcctagatg 1859581 aacagaaagc gctttcatta ataactaaaa acgtcttggt tatatgattg ttatcttttg 1859641 atcaactaat atgttcatac taatctccta atcaatgact gtcaatcgtt tttatgagct 1859701 tgtctcgatt acctaccgcc taacccaatg atttattagt tatatgttga ttaacttttg 1859761 gttatatgtt atgtttttta aagttgactg ccaatcatta tatctctcca ttgtctggaa 1859821 gcaaatgaga caatatgaga acagacggat aacaacttca taagaggagg agtacacatg 1859881 ccattattgc gttttgatgt aattgagggc cgtgatgaaa aatcgctgca attgttatta 1859941 gatactgctc accaagcgat ggttgaagca tttggtgttc cggaaagaga ccgttatcaa 1860001 attgtccatc agcatcccgc aaacgagctt ataatccagg atgcgggatt agggtttcag 1860061 agaaccaagg atatggtcat cattagcatg acaagcaaag caagaaccga aagccaaaag 1860121 gaaaaattgt atgctctgct tgctgaaagg ctagaaaaaa aatgcgaaat ttcccctgac 1860181 gacctcatgg tatctattac tgagaatggt gacgcagact ggagtttcgg tctcggtgag 1860241 gcgcaatttt tgaatggaaa actataagat ttcgtctccc cacaaaaaaa agaagagaga 1860301 gctccaaaga agctctctct tttttcataa atgcggaagt catcagtata gaagcatcca 1860361 gcaatacgaa aaacctggat ctccttttat atccggttta aatgccaatt ggaagctgac 1860421 tgggttttgg ctgaaaatat aaaattttgc tgatttgcat aataagatac atcataatcc 1860481 ccatttacaa taggttggat gttatagctt attgatcatt tcctatttta tatatcccct 1860541 tcatatgcac atgacatttt tgccaatccg gaaatatcag tctgacaaat ataaaaagtc 1860601 atgtaaacgg gtgtgaaccg tacttacatg actcaccatg gaaacaaagg ctctttttca 1860661 ggtgccgctt tccttatttc tcttcttcac acactgtgtc accaggctcg caaaattgat 1860721 cggcccatgc ctgcatttct tgaaatacag cttgaagcgc tgttcctttt tcagtcagcg 1860781 tgtagatgac tttgaccggc gtttcaggga gaacctgccg ttcgacaatc tcgttttgtt 1860841 caagctcctt caagcgctct gccaacattt tttggctgat catcggtatt gtttccgtta 1860901 tctctttaaa ccgtttcggc ccatccatta gcacatggat gatcagaccg ttccatcgtt 1860961 ttcccagcaa tgagaatgcg gattccattt tagggcacat cgtatttccc ataagtcttc 1861021 atcccttcat ctattgattg acatgtattc aatgatccat tacaataatc tttcaagtta 1861081 catttagtaa gcttctaact tttctattat cataccacgt ttatccgaag gaggaaacac 1861141 tatgacgaat actctggatg ttttaaaagc acgtgcatct gtaaaggaat atgatacaaa 1861201 tgccccgatc tctaaggagg agctgactga gctattagac cttgccacta aagcgccttc 1861261 tgcttggaac cttcagcatt ggcattttac agtattccac agcgatgaat caaaagcgga 1861321 gcttcttcct gtagcgtata atcaaaaaca aatcgttgag tcttctgctg ttgttgccat 1861381 tttaggcgat ttaaaggcaa atgaaaacgg tgaagaagtt tatgctgaat tagcaagcca 1861441 aggctatatt acggatgaaa tcaaacaaac attgctcggc caaatcaacg gtgcttacca 1861501 aagcgagcaa ttcgcacgtg attccgcttt cttaaatgct tctttagctg ctatgcagct 1861561 tatgattgcc gcaaaagcaa aaggttatga cacttgcgca atcggcggat ttaacaaaga 1861621 gcagttccaa aagcaatttg atatcagtga gcgctatgtt ccggttatgc ttatttcaat 1861681 cggcaaagca gtgaagcctg cgcatcaaag caaccgtctg ccgctttcaa aagtatcaac 1861741 ttggctgtaa ggatatgaaa aaccttagtc cgaaatccgg actaaggttt ttttatacaa 1861801 tcgcctcttt gtaccattca cgagcctgtt cagcttcatg ctgagtcagc tgatggcccc 1861861 cgtcctgcca gtaaacggag gctgatgccc cgctgtcacg caaatagcgg taaagctctt 1861921 ctgattcttc cttcgtgcaa agaggatcgt atttcccggc accgataaaa acagggagcc 1861981 ccgccatatc aggcagctcg ataccccgaa tcggaaccat tggatgatgc agaatagccc 1862041 cttttaacac atctttataa tgaaaaagca ggcttgccgc aatgtttgcg ccgtttgaat 1862101 aaccgactgc aatcactcgg ccgcgattaa actgatgcgt ttctgcagcc tcgtcgataa 1862161 aatctttcaa ttctcttgtc cgcaccacaa gatccttttc atcaaaaact ccttcactca 1862221 gacgtttgaa aaatcgcggc attccatttt caagcaccga tcctctgaca ccaagcaaat 1862281 gggcatcagg gtctataaac cgccccaatg aaagcagatc gtgttcatta ccacccgtgc 1862341 catgcaacag caaaagtacg ttgtcagatg ttcctttctc ataaatatgc ttcattataa 1862401 attccccctt ttaaagttca ggtaaaatgt ctgtaatttg ttgtctatgt ttctccagcc 1862461 attcaggcag ttttaaggaa gtccctagct cagcaaacgt ttcatctgtc ataaagcccg 1862521 gttcatctgt ggcaatttca aataagatac cgcctttctc cctaaaataa actgatgtaa 1862581 agtattccct gtcgagaatt tctgacgaag gcagatggtt ttcagcaata atcggcagcc 1862641 atttcgcctg ttcctttttc ttagtccgaa acgctacatg gtgtaccgta ccatatcctc 1862701 cgactcctct tttttcagga tgtaaatgga catcaatgac accgccgacc gccgctgaag 1862761 atgccagtct gacaatctgg tcttcttcgg ccactttggt gtatccaaag ctttccgtta 1862821 acaattgtat ggtcgcctgc gggtcgtagg aatatagcag cacacctttc attcccgtaa 1862881 ttgcttcatt tgttgtgatc ccgtcaggcg tccactcgct tttgccgctt ttcgcatcct 1862941 ccatgatcgc cagcggaagg tcttctgtat catcaaaaat aagacctttt tcaccaaaca 1863001 acgttttttc ctctaggctc agcccgcttt tctcaagacg ttccttccaa aaagacaggg 1863061 agcctgaggg aactgaaaag tacacccggc ccgcttggcc ttttcctacc gttccctgtc 1863121 cgcttccttg gaacggaaaa aaggtcatta ttgtaccggg atctccgttt tgattcccaa 1863181 agtaaaaatg atacgttccg ggatcatcaa agtttactgt ttttttaacg agcctgagcc 1863241 caagcacttc tgtataaaat cgcaagtttt cttgcggatc tctggcgaat gctgtgacat 1863301 ggtgcaatcc ttctgttttc attttctcac tcctatttat ctcgatttca agatatttat 1863361 tattttaaac ctttattgaa aaggatgcaa accatgtgtt ttgattaaat aattgaaaaa 1863421 atcatttttt tctaataatt atcttgtgat cttttcttac aactgctatt atagtgagca 1863481 ttatcatgtt tcaggaggaa agtaaatggt taaaaaagca cttattgtta ttctcattct 1863541 tttgccattc gttcagctcg cgcttttgcc gcttgtgaat cgaatagaac cgattatgtt 1863601 cggcctgccg tttttccact tttggctgct gctgtggatt attgttacgc cgttatgctc 1863661 gtttggcatt tatcagatgc aaaaaaaaga tggaggactt gaataatgca agggaatctg 1863721 actgcacttc tcattactgc tattattgtt ttaaccgttg tctgtatcgg ctttctcgcc 1863781 ggaagagaca aatcctcacg tacttctgtg gaagaatggt ctgtcggcgg cagacgcttc 1863841 ggcggtcttc tcgtctggtt tttagtaggc gctgaccttt atacggccta tactttctta 1863901 gggttgacca gtactgcttt tacaggcgga agtgttgcat ttttcgccat tccttattct 1863961 gtgttggcct actttatcgc ctacttcttc ttgccaaaac tttggaaagt tgcgaaaatt 1864021 cataaattaa caacactcgc ggattatgcc cgggaacgtt ttaacagtaa gcttttggca 1864081 agcctcgttg ccatcgttgg ggtactcatg cttattccgt acatatgcct tcagctgagc 1864141 ggcattcaag acacgcttca ggttgccggc actggctata ttaacgtaaa attcgttgtg 1864201 atcatttcat ttattcttgt tgctctttac acattcttca gcgggattaa agggcccaca 1864261 tatacagcca tcattaagga cattttagta tgggtcatta tgctgtttat ggtggtgtcc 1864321 ctccctctca ttcattttaa cggctggacg ccaatgattg acacgttagt gaaggaagcg 1864381 ccgcaaatgc tgacgatacc gtcagaaggg ccaaaaggca ttccttggtt tatcacagca 1864441 tctattgttt ccgctctggc actttttatg tgggcacatg ccgctacagg tgttttcacg 1864501 gcgaaaagcg ctgatgcagt aagaaaaaac agcatgtttt tgccgcttta taatatcgtg 1864561 ttaattttgg ttatttttct tggctttatc gcctttcttg ttctgccgga agatacaaat 1864621 ccaaggctgg cgctgctgca tttgattcaa acatcttacg gcggcgtggc acaaggcttt 1864681 gcatatgcca ctatcgctct tgcttcatta ataccttgtt ccattatggc aatcggcgca 1864741 tcgaatttat tcgccaacaa cctataccgg gatttgattc atccgaatgt gtcgcaaagc 1864801 aagctgactc ttgtcacacg ttcaatggtg tttgttgtca tcggtcttgc gctgctgttt 1864861 ggaatgctgt tcccgactgc cttagtgaca cttcagctat taggtgtatc cggtatggtg 1864921 caaatcttcc ctgcgattgc tgtcagcctg ttctggaaaa accaaacgaa agaagcaacg 1864981 gttatcggat tattagccgg cctagcggta acgtttattg tgtatatcac tcaatccgca 1865041 catggcattt atgaaggatt ctggggattg gccgccaaca tgatcgctgt ggtcatcctg 1865101 aatccgctgt tcgttaaaaa cgcgggatcc aatcctgtca ttgaaggttt atttggcaaa 1865161 aaacaagacg ctaatccaaa tcaaaagggc gcataaaaaa accatacgcg gcagccgcgt 1865221 atggtttttt ttacatttct tttttcagtg tttcaattgc cttttccatt tgcgtatcat 1865281 tatcagacag cttcttttga agttctatca ttaatttcgt tgttgtatcg ccagtcagta 1865341 tgcctgtttc attcagcttc tcttttttct ggaactgttt gacgacagat acaaaatcct 1865401 ggtcatacat actgttaacc tttaccttgt aaccaagtgc tttgagcatt ttctgagcca 1865461 ctttgacgtt tgtgcctgta tcacctgatt tgtacgtttt atctgcgtcc aaatacggca 1865521 gcttcgcgta atcaggcagc tctgctttca cttgaggctt gatgcctttt ttgtgaatcc 1865581 attcgccatc agcagtcagc catttggcaa ctgtcagttt gacggtagag ccatcatcat 1865641 attcttttgc cgtttgtact gtacctttgc cgaatgtcgt ctcgccgatt aacggtacgt 1865701 ttgacgattc atgaagggca gcggccataa tttcggctgc gcttgctgta ccgtcattta 1865761 ctaaaacgac ggtcggcttg gtcactttcc gttctttttc ggccttcatg acttcttttg 1865821 aaccgttttt gtattcaacc tgcatgatgt ttttcccttt atcaatgaac aggttgctca 1865881 tcgtaatcgc ctgttccatt aagccgcccg ggttgcctct caagtctaaa atatagcctt 1865941 tggcgccttt tttctctaaa ctgtcaatcg catctgtcag ctctttagct gttgtttcag 1866001 agaaagaagt gatttgaatt tctccgatgt tgttgtcttt catctctgaa tagacagtct 1866061 ctacaggaat ggtatcgcgc ttaatggaaa gatcgatatt ccccactccc gctctgttca 1866121 gttcaagctt cacctttgtg ccctttttgc ctcggattaa agcgacggct tcatttacat 1866181 tcatgccttt tacgcttttt ccatttacct taatgatttg gtccctcggt ttgataccgg 1866241 ctttttcagc aggtgaacct ttaattgggg atacaataag gatttctccg tctttctcct 1866301 ctacttgggc tccgattcct tcaaaagatg ctgaaatcgt ctcgtcgaat gatttcgctt 1866361 gctcttgatc catatatgta gaatacggat catccagtga ttgaatcatt cctttaattg 1866421 ctccgtctac taatttgtca tcatctgttt tttggtaata atcacttttg atttgctcat 1866481 acgctttatt taatttgtcg aacttgctgt ctcctgtgct tgctgatttt tggcccagga 1866541 tactggaatt gcccgtaata aataaagtaa gcgccgaagc gacaactgca gtgatcagca 1866601 caataaaaaa cagttttaat tgccgtttca attaaacacc acctttttct tcttacatta 1866661 ttatcatgga cgaattctta ttcgtcaact cggagcagaa atgaaagaga aacgcccttc 1866721 ttttgctttt cataaaccta tgtctttata cgacatatga taaggaaaaa ggaggattcg 1866781 atattgagcc gatatttaga aatgctgtcc ttattcggtg tcgcaggggc gcacccaggc 1866841 gggctggctt tttcaaaagc ggtcttgcaa aaggctgcac cctctccgga tcagccgatt 1866901 cttgatgccg gatgcggaac agggcaaacg gcggcttatt taggacattt gctgtatcct 1866961 gtaacagtcg ttgataaaga tcctattatg cttgagaaag cgaaaaaaag atttgcgaat 1867021 gaagggcttg ccatccctgc atatcaggcg gagctggaac atctcccgtt ttcttctgag 1867081 tccttttcct gcgtcctgtc agaatcggtc ctcagttttt cacgcctgac atcctctctt 1867141 caagaaattt caagagtttt aaaacccagc gggatgctga ttggtatcga agctgcttta 1867201 aaaaaaccaa tgccccctgc agaaaagaag caaatgatgg atttttacgg atttacttgc 1867261 ttacatgaag aaagcgaatg gcataaactc ctaagatcct atggctttca aaaaacagaa 1867321 gcgatgtcac ttcttccgga agacatggaa tttgaaccaa ccacagaaat ggatttatcg 1867381 caaacgattg atcccatcta ttacgatacg cttcaaacac attatcagct catgcagtta 1867441 tatagtgagt acatgggtca ttgtattttt atcgcgtaca agtaaaacgg cgtatcgccc 1867501 cctgttttcg tccaaccttt ttttcctatc tatcatatgc tgatagaaag tcaggatagg 1867561 aggggaacaa tattggagag atattatcat ctttgcaaaa accatcaagg taaagtcgtc 1867621 agaattacag agagaggcgg gagagttcac gtcggcagaa ttacccgtgt aacaagagac 1867681 agagttttta tagctccggt cggcggaggg ccaagaggtt tcggttacgg atattggggc 1867741 ggttattggg gatatggagc ggcttacggg atttccctcg gtttaattgc aggagtggct 1867801 ctggctggtt tattcttctg gtaagcatag aacaaatgct agattcacca gacacaatga 1867861 agcccgctta tctagtgtaa gcgggctttt cattttaaat tttcttcact ttttcaaagt 1867921 actcttcaag cgttaaatca ttatcttgga tgacctttgc ggcttttttg cctacatagc 1867981 gcagatgcca tggctcatat tcatatttcg tgatatcttc tttatttttc ggatagcgaa 1868041 taataaagcc atatttataa gcattgtcct gcacccattt cccgtctgcc gtgcttccga 1868101 acgcttcatt tagctcaaag ccattgctcc ggctcgaaat gtccatcgca aggcctgttt 1868161 gatgctcgct ttcacccggg taagcgaccg cttcctttgc cttcctttcc ccttttaggc 1868221 ttacttcatt gtcaaaaatg actttctgtc tgtcatacga acggtaccct gagacagctg 1868281 ccagttcata gccttccttt ttggcagcat cgaacattgt ttttaatgcg tcggccgctt 1868341 cttttctgat gtaacgtttt tgaatctttt cttcaaaaga aaactctaca tcaggtatga 1868401 caagatcgct aggttcatag tttccgggca gtgcatattg tttattgaca agcgcgagta 1868461 tattttctgg attttgaatg gtttccagac catcgacttt tttaatatca ttgaaatact 1868521 ggctttccaa tgaaaactca ctgttttgag tgtttgattt tttgctgtca gctgtttttt 1868581 gttctgtttg ctttgtttct gctgtggttt tcgtatcctt ttgagcatct ccgttcgaca 1868641 tgctgcagcc ggctccgact attgccgtta cactcagagc ggcagccagt gagaaccatt 1868701 taccggactt tttcatatta cattaccttc cttttatcaa tcgtttccgc atgcataaag 1868761 aagaggctgc cggcacccag cacgcctctt gatatatttt attgtgatac ggaatgtaaa 1868821 gccacttcta tcatatcatg aaatgtcgtt tgacgctctt ccgctgtcgt ttcttctcct 1868881 gttaatacgt gatcactcac ggtgagaatt gacagggctt ttcttccgtg cttcgctgct 1868941 aatgtataca atgcagttgt ttccatttca acgccaagca caccgtattt tgcaagtttt 1869001 tcaatttgcg aatcgtcatt gtagaactgg tcagctgtaa atacgcttcc tacagtcacc 1869061 ggcacacctt tatcctttgc ggcatcatag gcatttttta aaagctcgaa atctgcgcaa 1869121 ggcgcaaaat caacgcttcc gaaagcaact ctgttcattt gtgaatcagt tgaggaggtc 1869181 atcgccaaaa tgacgtctcg cactttgaca tctttacgaa tagcgccgca ggaaccgact 1869241 cttattagat tttgcacatc gtagctttga attaattcat tcacataaat tgaaatagac 1869301 ggaactccca ttcccgtgcc ttgtactgag atttttttac ctttatatgt acccgtaaat 1869361 ccatacatgc ctctgacttc attgtagcat tctacatttt caagatacgt ttctgcaata 1869421 aattttgctc tgagaggatc tcccggcaaa agcacagtat ccgcaatttg tcctttttca 1869481 gcacctatat gtacactcat ctcatatcct cctgtaaatc taaattatca tccagcccgt 1869541 ccattttaca acgaatgtca tgatgaaaca aacttcagca ttgattataa aggaatatat 1869601 cgaaaaaaga aatgttcgag gatctgttag gcacttcctc agaaaaacgg ataatcgggg 1869661 tgttaatttg aaaacctaac cgcaggaagg aggggtggga catgggtaaa aaacatcgta 1869721 accggatcac cggccaaaaa aagaacaatc atatacctga aaaagatatc attgcagctg 1869781 aagaagcaca cgggaaagaa tattccgctg ccaaacgcaa gccttaaaac tgcagaaaac 1869841 tgcgggtttc cgcagttttc ttttcattat gtcgtttgta caatcagacg attgattttc 1869901 ctccagccgg cgggaagcag ttgataatat gttttccctt ttctgccttc atcaatcagg 1869961 atcacgtccc ctgtggccat gaatcttgca tcataatcac tcggaacagt gtcgaataca 1870021 ttaaacaaag agaatgctct tttcagcacg tcttgatgat cgctcccgtt cagttcagtt 1870081 cgatagacgg ctctgtagcc ctttttttcg ccaaaccggg gtgtctgaaa tattgtcacg 1870141 tcataggaac aagacttctt tttaaacacg gataacatca tcaagatccc ctccctttta 1870201 tttctttaac atattggcgt ttttgctgtg ttttcctctc tctatttttg tcgaaaccgc 1870261 ttaatctttt cgtcaaaacc ttttactagg aaaaacagaa gcaagccgag gctaaagcct 1870321 cctaacacgt ctgtcacaaa atgaaccccc agatacactc tgcttatgcc gactaaaaca 1870381 gcaattacac cggctatgat atataccatt tttttatgct tagacaaaaa cgggagatgt 1870441 ttcactaaaa agtaagcaat aacaggatag acacaagcag cattcatgga atggccgctc 1870501 ggaaaactga aggatgattc atgaaccagc ggtgcaaaat caggcctcac tctttcgatc 1870561 cattctttta agactttgtt taacagccga tctgtgccga atactaagag catcaacagg 1870621 ccgtcccatg tttttctgta gaaaaacatg cctgctccaa tgatgacaat tagagggagc 1870681 agaaaagaag aagcaccaag atgcgtgatc cccgtcatga cttcattaag ccatggctga 1870741 cggatcaaaa cagctgcctt gcttattgct tcatctgcag attgaacagc atttgtatga 1870801 atggccgcag ctagaattaa aaagaaaaga aacaaactaa cgggcttgta caattttaac 1870861 cacctcaatt ttcacagaag tcatagaaca tgaataataa aaccggagct gaccgctccg 1870921 gttttaagcc tcactcatct tcatccagct cttcatctat catacatttt tctatcaaat 1870981 aatcaaaggt aatatcagcg atttcaaaca gctcatcctc actcggtatg tagccccgtc 1871041 ttgcaagctc tctgtaaaaa aattcagcga tttcttccgt atcaatcaca agatctattt 1871101 ctttcatctc cgtaccgcct ccttttttat gttttatgaa aaaacaggct gaattatacc 1871161 cggtgttcta aacaattctt tcagtcatat attgaataaa aaacgagcca tgggaggctg 1871221 acgctatgat tgctaaaatg atggaagcac tggacggaga aagatttgat atcataatgg 1871281 aaaaaacgct caaaggaatg acgcgtgtga tgatttgggg ctgtctgcca tattttttat 1871341 atgtcttgat ccgtatgttc acaaattaac tgaaatgctc ttttaaactt tccaaaacaa 1871401 acatcatcat gtctttatat tcttcatcct gaaacatttc gtacagaatt ttgtagtcat 1871461 tataaatatc cagaagctca tcaacaattg acacagcaag gatgtgaagg gtatcttgat 1871521 cttcatcacc gccttcaaac tgaagaagag cagacgatgc gatatcttcg ccgatctcat 1871581 ggccagtttc tccgacataa tggacaaaca acagctgatg cacaaactgg tccatttcat 1871641 attttctaag caccagcgtg agatcctctt cctccgtttc aagccactct ccatccttta 1871701 aacgggtcag ctcataaatg atatcttccc agccatcttc taaatatctc caaatttctg 1871761 ttctatggcc gataatgcga aagagttctt ttccataatc tttaacataa acaacgtccc 1871821 caataaggaa ttcatactca atatcaagct tctccatgtc gacaatgaca ccctcataat 1871881 ctttataaag ctgaatagat gattcaaagt ataaaacttc gttatgattg acttcataaa 1871941 gatagtgttt atcaatttgg tgtacttttg tgatggtgcc gactgttcca tacataatga 1872001 cgactacgat atcccctact tggaatttcg gtttattttg cttcatggtg tctccccctc 1872061 gccgcaacat ttctcatacg ctatcgtatg ccgggtgaag ccaattcgca tgggcatgaa 1872121 aaccaaagga aatatccaat tatggtatgg gtatggacat aaaaaaatcc gcagtgatct 1872181 gcggatgaaa cagctattat ctgccgtgca cttcagactc gtattgatcc caagcttcat 1872241 caaacgtcgc catcgtgtga aggtaatcag cattcagctc caaatatgaa ctgatttcat 1872301 gataatcggt tgatgttttt ggaaagctgt gatcctcata cgcctgattg gcaaattcac 1872361 tgatgctgtc cttcggctta gggtgtctgt atttcaataa atagtgataa aaggatttca 1872421 tgggtttccc ctcctgatgt ctgtcttttg ttgttctatt atacagttca agtgtaaaat 1872481 tacaacaaaa gaatactgaa acatgactca ggagaagtca aaatagttgc gtttcaaaat 1872541 tctttctgtc tccatgagct gctgatatgt caggctttca ggcagttttt ttgtttgaat 1872601 taaaagcagc tgatcctcaa tctctttaac cgtgttttcc tcttgatagg tcataccgca 1872661 ggaagaacat accatggcag gggtgtctgt cagttctata gccctcgttc catcagggag 1872721 ctcccagtac accgtgttcc tgccgggcac cgcttcgagc tcgccgcacc attcgcatgt 1872781 tttcatgaag aatcccctcc gcattcagtc tctttctgtt ttttctgctg cgccaaaaat 1872841 ttcttttctt tgagctgatc tcttttctca cgccgatctt ttaatgtttc atgctccgga 1872901 tttgcgatgt atgcctctct ccttttgatt ctgtctacat tttcaggtgt aaacgaaact 1872961 tctttgtcag caaaaatggc actcagcccg atcggctcct ttttgtcagc ggtttcaggg 1873021 aaaacggact caaaataggc gtctgcctga ttggggatat aattctctgg ttccggatat 1873081 gacgtaatca caccttcaaa atttcttaag atcactttgt caggactttg tgacaggaca 1873141 tagtttggct gcagggcgat tttacctcct ccgcctggtg cgtcaacgac aaaggtagga 1873201 accgcatagc ctgaggtatg acctctcagc ccttcaatga tctccaaacc tttggaaaca 1873261 ggagctctga aatgccctat tccttctgac agatcacatt ggtaaatata ataaggacgg 1873321 actctgattt ttaccaagtc atgcatgagc tttttcataa ttggaaccga atcattaata 1873381 cctgctaata cgacagcctg atttccgacc ggcactcccg cgttcaccag cttttcacat 1873441 gcctcaacgg attcttctgt catttcgatg cttgtgttaa aatgggtgtt cagccagacc 1873501 ggatgatatt ttttcaatat ctcgcacaga tgatcggtaa tgcgctgcgg aaagacgacg 1873561 ggagctcttg ttccgattct gatgacttcc agatgcggaa tgctgcgcag ctcttttaaa 1873621 atatattcta aaatttggtc gttgatgagc agcccatcac cgcctgaaat taaacaatcg 1873681 cggatttcgg gtgtttcccg gatataagca attgcagcat caagctgttt tttggggacg 1873741 cccattccga tttgtccgga aaagcgcctt cttgtgcagt agcggcagta catggaacat 1873801 tgattcgtga caagaaacag cacacggtcg ggatagcggt gtgtcagacc gggtaccggt 1873861 gaatcttcat cctcatgaag cgggtcttcc agatcgtatt ttgttttgtg catttcttca 1873921 gaaagcggca cagactgcat gcgtaccggg catctcggat tgtcggggtc cattaaagaa 1873981 gcatagtaag gtgtaatatt taaggggatc gttttggtag aaattctgac gccttcctct 1874041 tcatcctcgg tcagattaat gactttcttt aaatcatcta acgttcttac agtgtgtgtc 1874101 agctgccaaa gccaatcgtt ccatttctct tccggaacgt ccttccataa ctcgatctcc 1874161 ttccaatgcc gtttcggttt ataccatttg tttttcaaac gaactcctcc tcgcgcatat 1874221 tttgacttac agttgcttgc accaaatatt catgttttca aggccttcgg ctataaagca 1874281 attattgatc agccttccgc catactgata acctgaatgg tacaacacag cattcatccc 1874341 aaaagacgaa gcacgggcga gagaaaacac atgaacgata tcctctccag ccatttcttt 1874401 ttctaacgcc tcgattaaaa agcttgttaa cgaatggccg cgatattccg gcagcacagc 1874461 gcaatcggtt atttctgcat gcccaagctc tggattgatt tctgcgcttg ctgcgctgat 1874521 caggcggtca tgatcaagca tgatataata caccgtattt gcattcatcg tcttttcaat 1874581 ataagcgggg tcaaataccg gggttgggta cgtgcggaat acttttttat acagcatcga 1874641 tagctggtac atgtcgtttg tttctgcttt tctcatcgta aaaacgggtg tactgtcgtt 1874701 gcgaagacgg ggcgctgtgc gatatatggc ttcgatgatc tcctgttcct ctgtataaga 1874761 atctgtttgt ctccggcttt ctgaaaggta acgtaccatg acacaagccg aatggccgag 1874821 ataatagccc tttagatagc cctccggcgc aaataattgt ttggcaagga tcggctcatc 1874881 atgctgcttc gcatagacaa tgattttttc tgcattctct tcttttgccg ctgccacgat 1874941 atccggcagg gccttctcaa tggctccgtc ataacgaacc actctgattc gtttattaaa 1875001 gccgtcatgg tccaaaactg ctgtgacacc gctactcttt attgacttga gcatccgcat 1875061 cctccccatc tgtatgaagg ccgcaccaat ccatgacaaa aagtgcaata attttagcag 1875121 attctatcat ggcttcaacc tcaatgtatt cattggcctg atgagccgtt tttgtttccc 1875181 ccggcccgaa aacgatcact ggtgtatctc ctgcatggta caaaagccct ccatccgttc 1875241 cccacgggga agcctcaata atcggctctg tctgtttcat tttttgatag gctgattgca 1875301 gcacagaaat taaagggtga tcatcaggta aatcattcgg cagccattga gcgccaaacc 1875361 attcgacttg tacgggatgg cgtttaaacc attcgtcatg gtattctaaa tccttcagcc 1875421 agttttccaa ttcaagtttt acagcttctg gtttctcatg gggagcaatt ccgcatctcc 1875481 cttctatgac gacacggtct gcaactgaag atggccaggc accgcctgag atggtgccga 1875541 tattcaccgg taccggtatt gggatattgt catacagcgg atctgaaatt ctcgcattgc 1875601 ggactttctc cagctcttgt atcgctgtga taacgtgcat gcttttttca atcgcgctta 1875661 ccccttcata gcgtgtgccc ccatgtgcgg ataatccctt cacagtgatc cgaaaccaca 1875721 tcgaaccctg ctgcttaata aatagtttca tattcgtcgg ttcaggaatc agcgccccgt 1875781 cagcacgata gcctctcatg atggcggaaa gtgtaccggc gccgccgcac tcttcatcta 1875841 caacactctg aaacaataca tctcccttca gtttgacatc gcaggcgtgc agggcttcta 1875901 aagcaaaaag aagggctgta ttgcctccct tcatatccgt tgagccgcgg ccgtatattt 1875961 taccgttttc ttcgacagct tgatacggtt catacttcca atcctttacg cttccttcag 1876021 gcacaacatc gatatggccg ttcaaaatca gggacctgcc tccgccggct cccgtttttt 1876081 tagccacgat attcgggctc tcatgaaaat cggatcggtt agatttaaag tagggatgct 1876141 gttttaattg ctttatgctt ggctcccata catcaatgtc catatgaaat tgccgcagct 1876201 tttcaagcac aacagcttgg gcgttaaact ctgaccccaa tgtgcttttt tccccaatca 1876261 gccttttgag aagacgaatg gctttggccg aatgctgatc aagccactcg attacttttc 1876321 tttcaatgtc ttgcatcctc attccccctc ttaagaaaaa ggcatatcta ttttgatttc 1876381 agcttctgtc agcctcgtca cctcatcgat tgtcgagcca ttcatcagct cttttaaaat 1876441 gaagtgatgg ctatcgacct caagaaccgc tttttcggta ataatcaaat ctacacagcc 1876501 tgcagcagtt aatggcagcg tacatctttc tgttaattta ggccttccct tttgatctgt 1876561 atgactcatg acgacaacca cttttttcgc tttttgggca agctccatcg ccccgcccat 1876621 accaggcacc ttttttcccg gaacaagcca atttgccaaa tctcctgatt ggctcacctg 1876681 cagggcgcct aaaatcgtaa tgtcaatttt gccttttctg atcatcgcaa aagacatggt 1876741 tgtatcaaaa taagaagccc cttttacagc gcggacagga tatcccgcgg cgttgcataa 1876801 atgcgcatcc tcttctccct tttcgggact ttctccaatg ccaaggacac cgttttccgc 1876861 ttgaaacatg acctgcatgt caggcttcaa aaagttcggt accaaggaag ggataccgat 1876921 accgagattc acaatcatgc cctgcttaat ttcagtagca gcgcgttttg caatctgttc 1876981 tctttctgct actcccaagc ccatttccac ttcactccct cgcttcgtac aaccccctca 1877041 acaaaaaccc ccggtgtgac aatcatttct tcagaaatct cccccatcgg aacgatacgc 1877101 tcagcttcgg caaaggttct cctggcggcc attgccataa gcgggttcat attgcgcgcg 1877161 gttttgtcat acgttagatt gccgaattca tctgcaatgt aagcattgat gaaagcaaaa 1877221 tcagcagtca gcgcctcttc aatcaagtat cgttttcccg ccactgttac gatgtccttt 1877281 ttttcgcaaa ccatttgatt atcaatgccc acgtcggtta aaataccgcc aagccccgct 1877341 ccgccggcgc gaatccgttc cgcaagcgtt ccctgaggtg aaaattgaac ctctaacgtc 1877401 ccctctgtca tctgttttcc ggctactgga ttggaaccga tatgcgaggc gatcagggtt 1877461 ttgacccgtt gattaacaat aagcgggccg attccgatat ccgggaaacc ggcgtcattg 1877521 caaatcacag tcaaatccgt tacaccgctg tccaatatcg cttcaatcaa tgaaggaggc 1877581 gacccgactc ccccaaaacc gccaaacatc agaaccgatc catcccgaac atctgcaatt 1877641 gctgtgtcaa tgctgattgc tttttgaaat ggcgccattt aatgtcaatc cttttttaag 1877701 tttttttcga ccgctgcaac tgtttctgaa aaaatagaga taagctcttc catttcaccg 1877761 tctgaaatag taaaaggagg agcaataatg acagcatctc cttctccact gtctattcca 1877821 gctttggaag gataaacaat cagcccgcgt tttttcgcct cgctgacaat aagctgggtt 1877881 atcgcctgct ctggcggaaa cactttcttc gttttttggt ctgccacaaa ttcaatgcct 1877941 aatagcagtc cttttccgcg cacctcacct ataatgccgc tttgagatgc cgcctcatca 1878001 agcttcttct tcagcacagc gccctttttt tctgattgtt tgatcaagcc gtgctttaac 1878061 acatatcgca aaacttcaag agcagctttg gctgaatagg gatgtgcact atatgtgtga 1878121 ccgctcataa tcacacctga cccttgtttt atggtttcaa taatagaatc agatacgacg 1878181 gcagcagcaa taggtgcata ccccgcaccg agtcccttcc ccagtacagc aatatcaggt 1878241 acggtatccc aatgctctgt cgcgagcatc cttcctgttc tcccaagccc cgtcatcact 1878301 tcatctgcaa taaaaagcac atcgtgtgtg cggcatacct cacttaatct ctcataatat 1878361 cccggaggcg gagtaatcgc tgctcctgca gcaccaataa taggctcagc cacaaagccg 1878421 gcgatgaatt ggcttccgat tcttttaatc atggtgtcca gttcatcagc tgcagtctga 1878481 acaaagtctt cttccgtctc gtgattcagc cgataaatat gtggagctga gatagctgga 1878541 taccgctcaa tgagatgggt gaaccggtat ctcctttcat aaaaaccaga caatgaaagc 1878601 gctcccaaag ttattccgtg gtaactgctc catcgagaca aaaagatgga tttttgtgtt 1878661 tgcttttttt cctgccaata ctgaatggcg attttcatag ctgtttctat cgcttctgat 1878721 ccgctgttga caaaaaaaga ccaattcaca tctccgggca gctcctgtgc caagagagcg 1878781 gctaattgct cggcgggctc actcgtaaac tgtgagcggt aagcaaaaga cacctgatca 1878841 agctgttctt tcagcttctc agtcacatca cgaactccgt ggccgatatt acatgtcacc 1878901 gcacctgacg agccgtcgag atattttttt ccggtctgat cataaacata tgaacccttc 1878961 gcataactga caaccggata ggccgagcta agctctggct taatcaaata actgctcatg 1879021 ctcccacctc aaaacccctt ttaccatatt gtatgagtgt ccaaatggcg gcatgacgtt 1879081 ccccgcaaaa actttttcac ataaaaagag ccttcctaat aaggaaggct cttttgaaat 1879141 ttcagcatct agcaaataaa agcggctcca acaataatta ataaaatgaa caagacaaca 1879201 attaacacaa atgtatttgt cccgcagcca aatccgtaac cgtacccaga gtatccatac 1879261 atgctgtttt catcctttct tatcacgata tacgacattt tatgcgggcc aagtcccaaa 1879321 tggtttgtgc aaacgcctat ttcatgtaag gaaataatga aatacagtat gcacccgctc 1879381 atatttttta aacgtcagct tttcgtaaaa ctgagttgca ccgtcagtgc ttgcagccac 1879441 taagtaggct gcttccattc ctagtgattt ggcgatggac agcatttctt tcactaagat 1879501 actgccgtag cccttccttt gaaactgatc taaaattgcc acttcttcga ttttagccgt 1879561 tttctcttga tgatcgataa acagctcgcc gcacccaatg ggaactttct gtgcctggtc 1879621 gctgtaacaa acaacaagaa tgattatatc tgcttcatag aaaggatatt ttctttttaa 1879681 tttttgttca gcgattgctt ctccaatata aatggaatcg taaattttca taatagaaga 1879741 tccgtcgcta agactttttg ccgtccccca tgcggttaaa ggatgtccca tctgcccctt 1879801 ccagtcacta agcttcatgt catatagtag ctcatcctcg acgacaaaac cgctttttac 1879861 aagtgactgc ttcaaaccga gcggaaaaac atgctgcggc gacgctttta aatggagata 1879921 attcgcatca agcagctttg gtacggaggg taaaaagtta agtaaccgct ccaatggaaa 1879981 cgtatcatgg agctgaacaa agttatgaga aaaaatttgc ggaagctgcg gatctctgta 1880041 tacgctgtaa tgatcaaacg atgccgattc agacgttaac aatatatatt gatgttccgt 1880101 ttttgaataa tgtcctgtca tgaacgtctc ctttttatga cctatacctt tactctgttg 1880161 caatattcaa tttctttata atctcatcgt acaccggata aaacggcttt ccaattggaa 1880221 attgctgaat atttcggaaa gaagcggaga ttggcttctg atgtaaaaaa aacttccttg 1880281 ttacttgttc actaatcggg tgaaagacgc cgtttagaaa caaaaacggc tcgcgttcga 1880341 tgaaaaacag acgtcggcca ggcggatttt tgatcaattc agatcgtttc cacgtaatcg 1880401 gcggcccttc cggaagcgtc tccatctctt cttttccaat tgtcactatg tcttttcttt 1880461 gaaattgata aaattgaaac gcatactggt ccacaattcg cctttttttt ccggcttcga 1880521 tataaaatat tgcaggatgg tcagcttcct ttactaaaat ataattcgga atgtttaaaa 1880581 ttttgccaat cctatattgg aataaatatg ggtctggaac agcgacagtc cgatttagat 1880641 acaaaaaacc ccacttttct ccaacaggat gccttacacc ctgatcaaaa aaatacacat 1880701 tttgatctga accttttaca aaagagccgt caatcaaatc ggcgggcaga aaccgatatg 1880761 cattttgaaa tgaatctggg gttttatagg ttgtgtctaa tacttcattt atcggcagaa 1880821 atggggtaaa gttgttgagt ctcgcccaaa aaattgcgtc gccatgattc caatgcttca 1880881 tatcatcatc ccagtagcct ccaaatttat ggtgaatgag attaagtaac gaacggcgat 1880941 gcataactga gcaatgatca acttgaaaag cggcctgatc aagcactgca ttggcatttc 1881001 tgtagaaatg tgagatttcc tctccccttt cgtttacatg tacaactttt tgttttgaat 1881061 agaccgcctg cgcttcaggc ttatgtgaaa actcttgcac catacggctc agccgctcag 1881121 gatgataaac agtgtcgtca gtaagatagg aaatgtaatc gccgtctgca aatgggagcg 1881181 cactgttaat taatgtggca taacgggctg tttttaatcg atctgcagga tgcacgaaac 1881241 tgttatgata ttgaatgcgc cggtcatgga gatacttgtg aatcaccgca gttgtttctg 1881301 cattcgaatg atcatccatg ataaaaagct cccaaagatc atgcgtttgc tgtatcacgc 1881361 tttcgatcgc tttttgcaaa taatcgggtt tgttgtaact tgttaaaata atagacactt 1881421 tctctcccat ctataccgcc tcccgccgtc aaacataaaa acggctccgc agcaagcaga 1881481 gcctctgtca tcatttaaaa agcaccccag cttacaacac ttgagagtga aacatgagat 1881541 ctcgtgttat ttaacgggtt ttggaaaata accaaatcag tcagaacttc ttttacgatg 1881601 acattttgaa gtgtatctcc gttgatcaaa ttgacttttg aaaccggtac gcccagctct 1881661 tttgcaaaaa caagctggcg tctgaggtca gatggatttc cttcagaaga cgattgacgt 1881721 atcagcagaa tcagcaaaag caaaataaaa tgcagatcat cttggttttc ttctcgatcc 1881781 acttgtttct ctaaatccaa atcatccctc tcccttatcc ttatctctgt ttcacaatat 1881841 gtgcgacttc gatttatggt ataggctatg tccactccat taaaaaatca gcattttcct 1881901 taaatagatg aaaaatagat caggtacggc gttcgactca taccaaataa cagccggaag 1881961 aatatgaata acgtgagttc actatcgaat aggaggtgtg tgtaatgagc tctgaaaatg 1882021 cacagttaaa aaaggattta attaaagccg ttttaagccc tttatttcca actgcaacag 1882081 aaggaggaga aaatatggat agtaatctta aagccttgct tgatgctgcc atcgatcaaa 1882141 aagtagatga aagtgaaacg gttacggcag aatctatttt agacccttct cttccggcaa 1882201 gatggatttt tgccagaatt acgccaggca ctacaatcag cattgtgact gattcaggtg 1882261 acatgatcgg accggttgtt ttcgttgctt tcgatcaggt tcacgggatc gtatttgtaa 1882321 cacaggaaag ctccgtcact ccggcaggcc aagctacaac attaattgat gtagacaaag 1882381 tagaaagcgt tacgttcttt tcataacatc cgatgaaagt cttgtatatc cagtcgggat 1882441 acggaggaat atacagttat tttgatcgct gggctgaaga atgttttcag aacactcata 1882501 cagagtatat gattgcagat aaacctgaag cagaatcttt gatgaagatc gaagcgtttc 1882561 agccggattt cacacttatg atggttggag accgcgttcc tcacgactgg ctgacctggt 1882621 taaagggtaa ggatatcccc gtgtatgttt ggctgaccga agacccattt tatatggata 1882681 tcagccttca ggtaattaag cttgctgacg ccatattaac gatagaacaa aatgcagctc 1882741 tctactatca agagctcggc taccagaacg tctattatgt tccgatacca gttaaccatc 1882801 ggctgtttaa aaaaatgggc accgaacatt cctatcattc aaatctgtta atcatcggct 1882861 atccttaccc taatcgggtt cagcttatga aagaagcggt ccatctgcca ttcacggttc 1882921 gggtaatcgg caaggaatgg ggaaaatatc tgcctaaaaa agtgctcaaa cagccgcata 1882981 ttgatgtcgt cagcacatgg gttccacccg aacaggccgt tcattattat aatggggcag 1883041 acatcgtaat taatgcgcat cgtccctatc attttgcttt caaccaaaat actatgcgca 1883101 tcaaaaatgc cagttttaat aaccgaacgt ttgatatcgc tgcatgcgaa gcatttcaat 1883161 taacagattt acccgcggcg catccttttt catccattat ttcttatcac ggcatgaacg 1883221 actttaagga aaaagccgct ttctatatca accaccctga agaacggcaa aaagctgcag 1883281 cagccaatta taaagagacc gtacccgcat ttacgtttga tgagcttcct gcaaaactaa 1883341 aagcgattca tctggcgctt tcttgaaaaa tcgttcattg ctatgaacga tttttttatt 1883401 catagaaaaa agcagctgca caagctgctt tctattctag ccgtcagaac ggtctttcag 1883461 cttcctcgga tttacctgtt tatgaagatc aggcatttcg ccgagatgct gtgcaatttg 1883521 ttcccacgat acaattttga aattttgatt gacggcttgt ccgttatcaa tattttcgcc 1883581 gtcctgcgcc acaaaaatcc cgtacggata ttttgggcca agtccgaaac cgagaacatc 1883641 aataccatcc gtgtcactag taccgtctat cttctcgcca tctgtaatct caaagttggc 1883701 tacatagcga tttttcccct gccgttcata cattgcatag ctgttatttc cttgacttga 1883761 agccatgaga tatcctttgc catttggtgc ataatagatt gtcagtcctt caatatcagc 1883821 tgtcaaatga tctcctgtcg cacggtcaac aacctgcccc tttgaccctc cgccgggctc 1883881 agcgttaaat ttccagatgg cctcatcttc ctctgctatg tataggtttc cgtactcatc 1883941 atccgcaaca aggccttcgg tctgagaatt caacttaaat tcacgcacct ttttccctgt 1884001 tacataaccc tttccaccat caacaatttc atactgctca aattcccctt gtttgcctgt 1884061 cactaatgcg taaaatgctc ctgttttctg gctgtgatac aagctgaatc cataaacctc 1884121 agaaatattg gtggaaatag gatggttcgg atctgtaatg cttttcaatt ttcctttatc 1884181 cccgtctatt gcatatactt caattgtatt ttttccttcg gaccggttgg atgcggcagc 1884241 aatatcaatt ttttcgccgt tcaatggaaa atcatagcgc agatcgacat tattgagctt 1884301 gccaaactca taagaatgaa gctgttttcc gtctaaatca tacacaacga gccctgactt 1884361 cttatttgtt gtaatcaact tgcttttttc cgggtgtttt tcatgaaccc aaatggccgg 1884421 gtcatctgct gcatcatcgc cagatgcgac cggatctgtc tccgtgtgtg cagtcacttt 1884481 gaaatgatgt tcctcattca cataatgagc cgacaccgag gttgctgtca ggctaagcaa 1884541 taaacccgcg gcagtgctta gcagcattgt ttttggaacc ttcatttggt accctcctct 1884601 tttatcacta acactactat tgtaaaatat atacaggtga ttaccgtgag gaaaatgaac 1884661 ctttttttat agggtttctg actcataaac aacttattcc ccaaagaggt ggtgagatga 1884721 ctttgccaga tttacttttg cggagcgaaa taaaaatatg ttgaatattt agtacattat 1884781 ttatttagtt ttgtttttcc ctagttacgt ccgtttttcc attttctatt aaaaaagaac 1884841 actttgtgac atgatcattc ccctaaattt tgttttattg gttgctttca ttaattcgat 1884901 tacaaagttg aacatatgat gcatggtaga gaaacgagag ttggaggata agccatgcct 1884961 aaacagcaaa cagcagaact aaaaccattt ttccataaca aaacagtttt agtcactggc 1885021 ggaacgggtt caatcgggag tcaaattgtc aaacgccttt tgatgcttac acctaaacag 1885081 gtgattgtat tcagcaaaga cgacagtaaa cagtatgtca tgagccaaaa gtatgcggag 1885141 gataagcggc tattatttgt acttggagat gtacgcgatc acagaagggt gaatcaggtg 1885201 atgaaaggcg tcgatatcgt ctttcacgcg gctgcgctga aacaggttcc gacatgtgag 1885261 gaccatccat ttgaagcgat ccagaccaat ctcatcggcg gacaaaatgt ggtggaagct 1885321 gccctttcac accgagtgca gcatgtcatt aatatcagta cagataaagc tgtatctcct 1885381 gtgaacacaa tgggtgccac caagctgtta tctgaaaagc tgtttcatca agcaaaccgc 1885441 cacgtccaaa acaaaggaac cttgttttgt tcggtccgct ttggaaatgt tctcggttcc 1885501 agaggttcgg tcatccccat attatttgaa cagatgatgg agggtgaacc tctgaccatc 1885561 acagacaaaa acatgaccag atttttcatg tcaatagacg atgcagctac attgacatta 1885621 caatcggctg ctattacaaa aggcggagaa acctttattt tcaaaatgga atcactgaaa 1885681 cttgaagaac tgattcatgg gtttgaagaa tatgcatcgc agcacgggct cccgcggccg 1885741 gctgcagtag aagtgggcaa gcgtccaggt gaaaagcttc acgaagaatt aacatctcca 1885801 catgaaattg aatcactgta tgaatggggc aacctttatg cgatccttcc agagccggaa 1885861 aaacatcctg actttcgcaa agtcaatctg cctgggtatc aatcagatca agccccgctc 1885921 attacgaaag aaagaattgc tcagattatt gaagaattgc atcaagagaa aaaggcataa 1885981 aaacaagcct gtctatccat taggcaggcc tgtttttaac agtttattta ttaaagagat 1886041 gcagatagct ttcgtatcct tcttctttta gcttatgctt cggaacaaac cgcagcgctg 1886101 ctgaatttat gcagtaacga agtccgtttg gccccggtcc gtcattaaat acgtggccaa 1886161 gatgagaatc agcagttcgg cttcttactt ctgtgcgaat catgccgtgg ctcgtgtcca 1886221 gtttttcttc cacttcttct tcaatcggct ttgtaaagct tggccagccg cattgggaat 1886281 caaatttatc tttggatgta aacaatggct tgcctgacac aatgtctaca tacaaccctt 1886341 cttccttatg atcccaatat tcattttgaa atggcggctc cgtgccgtta ttttgcgtta 1886401 cttcatattg catgcgattt aatgacttta ttttttcttc tttattgtac gccatttatt 1886461 tagcccccca atgctcgctg ataaatcccg ctcgtccgga acctgtccgg tagcgctgat 1886521 aatgtgctgg attcttttta taaaaatgct gatggtagcc ttccgcttca tagaaaggtt 1886581 cagcttttaa aatgtccgtt acaatcggat ctttaaagat gccgctttcc gccagacgtt 1886641 gcttggaagc ttccgcaagc tccttttgtt tatcattatg ataaaaaatg gctgcgcgat 1886701 aggaactgcc gcgatcagca aattgccctc cggcatctgt cggatcgatt tgctgccaaa 1886761 ataattcaag cagtttttca taagggaata catcaggatg aaacgtgatt tgaacggctt 1886821 cacgatgtcc cgtcgtttca ctgcacacct cttcgtacgt agggttttca gtatggccgc 1886881 ctgtataccc ggacaccact ttttcaattc ccggctgttc gtcaaaaggt ttaaccatac 1886941 accaaaaaca gcctcctgca aatgtggcga tttctttttt ttcagacata ctggtgcctc 1887001 ctttgttaat acgtggtatt attatattat agcatgtaaa aatagaatga aaatgattct 1887061 gcttttcaat aaaatctata ggttttaagc aatatgctta tgtaatggag gttcacaaat 1887121 ttgaaagtaa gaacacagat gatgtacgat atggaaactt tactccgtaa agtctttaaa 1887181 caaatacgca atgaaatcaa tgaaatttta gataaagagc tgtcgcggaa tgaattcacc 1887241 attcttcgaa tccttagtga acaagggcct aaaaaagtca ctgaatttgc gcctatttta 1887301 gaggtatcgg caagccacat tacggctgtg accgatgcgc tggtagaaaa ggaatggatt 1887361 acgagaatca gatcgaagga agacagacgc atcatccgca ttcatatcac tgaagcgggc 1887421 gaaaaagtcc ttcagcactt taacgagaaa aaaacggaat atttctttaa acgctttgac 1887481 tgctacactg atgctgaact tgccacgtta atcgagctct tcagcaaact tgataaaaaa 1887541 cggtgaaaaa aagcacatac cgatatatag gtatgtgctt ttcgcagtgc ttcacttatt 1887601 tttcagtaaa cagcttcatt gctttccagc ggccatatct ataatacaaa aatgccgcgc 1887661 agctgctaaa taaaaaactc attccgattc caagcccgat tcctttttgt ccaagccaag 1887721 ctgaaaatag agctgtgaaa ggatacctca acacccaaaa cgagatcaaa tttaatacca 1887781 gaacctgcag catcgctccc gcggccctga cgattccgtt cagcacaaaa ttaaccccaa 1887841 taaaagggta gaaaaacgcg atccacttca aatattgttc accaaatgcg accgcatcag 1887901 gctcactgat aaataacctt atgaggtatt taccaaatac ccaaatcata accgcaatca 1887961 ccagcatgca ggaaataaca gctatcacac ctagccttgc aattgttccc actctttttt 1888021 cgtttccgat tccaatattt tgccctgcca tactattgac ggccgtaccg gcagccattg 1888081 ctggaagcgt gatgatgcta tcaagccgct gcaccgcgcc aaagcctgat accacgtgat 1888141 ccccgtatga gttaacaaca ctcataatcg ccatcatacc gcctgtaatc accatcatct 1888201 gcagacctgc cggaatcccg agtttcaaaa tcagcgcgga ctcttcccac ttgggcattc 1888261 tcggaatcga gaatggcaca agcttgtgtt tgatgacata aaacaaccca tacaaaaacg 1888321 caatgccctg tgacaaaatc gttgaataag ccgctcccgc tattcccatg cggaacacag 1888381 aaataaagag cggcgcaagc actgtattca gtacaacagc aaacgcaata aaccggagag 1888441 gtgtcttgct gtcgcccagc gcacgaagca cagtactgat aaagttataa ccaaacaaaa 1888501 ataaaatgcc gataaattga atctgtaaat acgtctcagc aagcggtatc attgactccg 1888561 gcgtttttag aagacgcagc aaaagctctg agagaaaaaa accggccgcg ccgaatccga 1888621 tgcttaggcc tgttaataaa acaacaaaag cgttaatata cgacgccatt ccttttatat 1888681 catcttttcc tttttgctga gataaaatgg ttaacgtcgc attgttaagg cccaaaataa 1888741 aagacagcac ggtcaaaaca atcgtgcttg ataccgcggc tgccccaagg gcctttgccc 1888801 ccagtaaatt gccgatccac aagctgtcta taaattgaaa ggaaacctgc aatgcgtttc 1888861 cgagcataat aggcattgaa aacagtacaa gctgtttcag cacgttcccc tgtgtaaaat 1888921 cgtatgcttt catcttttct ccttgtgttc tcaaattttc ttcggaccac acgaaaaaag 1888981 agacgttgtt tcatgtctct tttttcatga cttatcggtt ttttttcggt ctcgcatacc 1889041 gaatgtaaac accatcacac ttaggaacaa ggcacaatag gaaacattca aatacatttg 1889101 atccatatct tcagcagcca gatgatgata agcaagccag ccgaagtaca gggaaaatgt 1889161 aaaggataat aaactgaaat actggtaaat ccgtttcatt ttcagtcacc tctattgttt 1889221 aggatggtaa taggaaaact caatttcatc tttttctaaa tttatcttat ccgctttgac 1889281 atacattcca ttcgttaaag gcatttctga caaacgcact tcaatgcttt tatctccggg 1889341 gtgaacatgg acaaatgacg gcaattcata aaagctgtcc atataattta acacaaagct 1889401 aattggtata ctcaatttcc ctaacgaaaa tttcgtgaca ttcagctcta catcaccgtt 1889461 ttttttcacg gtcggctcaa aagcgataaa cgcatcaata gacgtggaaa atgccttgat 1889521 tttccctgcg acatgaacat catcatcaat ctctacttta taatcaagct tgtttgatgc 1889581 tttgtcgttt aaatatgagt taacaaacgc agctaatgat tcttttgtgc ttgtcacttg 1889641 aaatccatac tcgctctcag atgcatcttt cacctgagcc tgttcccccg gaagcaaaac 1889701 aagtgccaca aacccggcgg cgaggataaa attgattgca agcaatataa aaaacagtcg 1889761 cttccactta ttcatgctgt caccctactc tttcggtaat ccttcttttt taatggcttg 1889821 atagacgcgc tttgcgataa gagaataacc cgtaccatta ggatgaaaat catcttcctc 1889881 agaaattcgg ctgctgtcac ttttttgatt aaacaaatct tcgatatgga cgatttttgc 1889941 atgtttatct tttttcagct ctttttcagc aatatggttc caatccgtga cgacaccatt 1890001 tatttcattt agttctgata atgtaaacgt aaacggattg tacatgctga cataaatcag 1890061 ctcagcgtga tcattcagct cgcgaatttc agaaatgatt ttttcaaagc gcttttcgta 1890121 cggtttttcc gcttcctgaa acggttcaac ggttaattgc agaaagtttt ggcgaaggat 1890181 tttcatcaaa tcattaccgc caattgtaaa aaagacataa tctgcgtcct ttatgccttt 1890241 ttgaaccttt ttatctttta gtttttctaa taaatcatcc gaacggttcc cttttacagc 1890301 ataatttttc acgtcgaccg ttttgacttg tttatctgac cggatagaat ccgccacctt 1890361 gccgacatat ccctttccgt cgggatctcc gactccttct gtcagcgaat ctccgacagc 1890421 cgctatgaca atgtgttctt ttgttttcgt ttcatgggct ttttgttttc cctcagatga 1890481 tgtacgtatg ctcgtacacg cagtaagaag caaaatcaaa ctggccatga ttgaaaaaat 1890541 gcgcagcttc aatcttgttg ctccttccca ttctactagt ggaaagtgta tcatgtttta 1890601 gaagatttgc aaatgcctag tctcttagct tacttgagtg tactggctga cttcacatcg 1890661 gaaatgatat catcgtacgg tgtattctcc actccattgt aatctttcag caccttaccg 1890721 tccggaccta ccaaataaaa agaagattga tgaatcactt ggtcctctcc ctccggcttc 1890781 tttacgatcg ctttaaagct cttaagtgcg aactcctcaa tctcactctg gctgtatccc 1890841 gtgagaaaat cccagttatc aaaagataat ggataatttg cggcaaattt cttcagctgt 1890901 ttcggcttat cgttttctgg atcaacacta aatgatatga tgcggacatc tatattttcg 1890961 gctttcagtt ttttttgcag atcggtcata tgagcggtca ttggcggaca tatagtttca 1891021 caattggtaa aaataaaatc cgccagccat acttctcctt ttaaactctc taaagaaacg 1891081 ttcttgccgt cttggttttg aaatgtaaaa ggctccacct cgtaattgag cggatcttta 1891141 atctgctgtc ctccgcatgc acacaaaaac agaaaaatca gcccagccgt taaccccttg 1891201 ataaccttca tgacatccat cctttccagc cagcataaaa acgctttcta aaaccgtcct 1891261 tactgtccca tgtttgtatt cgatactgag caaaaaaaat cctgcatgcc tccccattaa 1891321 cgattacaaa ggagggcatg caggtaaaaa acggcatgtt acgcgttgtg ctttaacacc 1891381 tcttgatgaa atacagcctg ataatctgcc cacttcatcc gccgcttcat ataatgtcgg 1891441 aaagaataca cttttgccct gctgtttgat gaaaacactt cttttaagta gaattgcaaa 1891501 tggtgatgta acataaagaa atagtgctca tcttccttta atacaggtat ttctgtcact 1891561 ttcacctgaa tcccgtcacc gcgtttgaac tctaggcttt tgagtaacaa gctatcaatc 1891621 ctcttttttg tttttcttct attatatatg atgccagccg ggctgtctgt cattttgcgc 1891681 ggttgtgtaa aaaaattaga ttagcaaatg gaacaagtcc tcatccttgt tcacctctac 1891741 ataatgaaac ggttttttgt tcatccgttc aatcagcggc ccataatcgg ctttgttctg 1891801 cagctcgatg ccgacaagag caggtccatt gcttttatta tttttcttcg tatattcaaa 1891861 ccttgtaatg tcatcattcg gcccgaggac ttcgtcaaga aattcgcgga gcgcccccgc 1891921 tctttgtgga aaattgacga taaaataatg ctgaaggcct tcaaaaatca aggaacgctc 1891981 cttcatttcc tgcattcttc cgatatcgtt attgcccccg cttaccacac acaccacgtt 1892041 tttcccttta atttgatcct tgtacaaatc aagcgctgcg acagaaagag ctccagccgg 1892101 ttcagcaaca accgcacatt cgttatataa ttcaagaatg gatgtacata cttttccttc 1892161 aggcacaagg agaatgtcat caacgacagt ttccagcgtc cggaaggttt cctcgccaat 1892221 ttttttaaca gccgccccat ctacaaactt atcaatttta tcaagtgtga cgacatgccc 1892281 agctttgttt gattcaaagt aggatgccgc tcccgccggc tcaacagcaa ttacctttgt 1892341 atcaggagac acgtttttca aatatgtacc taccccagag agaaggccgc cgcctccgac 1892401 acttgcaaaa agaaaatgcg gttctgtatc aatgtcgttt aaaatctcga ctgcgagcgt 1892461 tccctgtccg gccatcacat ccggatcatc gaacggatgg ataaacgtcc gagattccgc 1892521 ctcacagcat tcagcagcgc ttttatacgc gtcgtcaaac gtatcgcctg tcaaaataat 1892581 atcgataaat ccttttccga atagttcaac ttgagatact ttttgtctcg gtgtagtaga 1892641 cggcataaaa attttcccgt gaatgccaag atgtttacac gaaaatgcca caccttgagc 1892701 gtggtttccg gcacttgcac acacaactcc gttctctgtc tgctcgctgg aaagctgttt 1892761 cattttatga taagcccctc tgagcttaaa agatctgaca acttgcaagt cttcgcgttt 1892821 taaatagata ttgcattcat atctctcaga aagtctgtca ttcctctgca aaggtgtgtg 1892881 aatgacaacg tcctttacgt tttggtgagc cttcaaaatg tctttcactt ggatgagaga 1892941 gttttcttta agcaacggtt tcatgtacag attcctttct tgttttaaat ccctatttaa 1893001 tatgccatta taacatgaat attcaaaaaa taagacaatt atttttattt aataattaaa 1893061 aaaatacaga ctatgtccac cacatcttgt ggtaacttct gttcaaccat tatcctgcag 1893121 agccaagaaa aaagatgatc gtaaaataaa gggtgttttc aaccaaaagg catgatataa 1893181 tgaaaccaat tagaaccaaa aggagccaat tgatgaatag tgcaccaaaa ctcaatacat 1893241 ttcaacatct aatcggagaa catcaaactt ttctggaagc gaagcgaatc gccaagcagt 1893301 tctcgttatc ggagcttcct gtcttaataa caggaaaaat cggaacaggc aaaaatcact 1893361 tcgcacatgc catacacttg gaatcttcga gaagcaatga accgtttata agcgtcaatt 1893421 gcagcaccca ttcggaagaa acccttattc atgagctttt tggccctaac ggaaacacag 1893481 gtgtttttca aaaagcggta cgaggaaccc tttttcttga tgatgtatgg cgcatgcctg 1893541 cttctgtaca agctcagctg ttaaaagcgc ttgattcaga cacggagaaa ccgcgaatga 1893601 tctgtgcttc tgcagaccga tccgtggaac atacattcag gcaagactta ttctacagac 1893661 tgaacatttt aacgctcaca ctgcccgaat tatcggaacg aaaaagcgat attccgcttt 1893721 tgacacagca ttttctctca aattctggtc agcaattgtt aatcgatccc tccgtttttc 1893781 ccgtgcttga gaagcatgca tttgaaggca atgtcaggga attaaaaaac gctgcagatt 1893841 atatggcggc agtatcaagc gggggaacga ttcagccata tgacctgccg ccgtatatta 1893901 gaggcacgat agacggaaaa acgtcgaaga aaaaagcgaa actgcttact ttaatggaaa 1893961 aagctgagtt tttgtttatt ttggaaacaa taaaagtatt gaacgaaaaa ggagaacctg 1894021 ccagcagacg gatcatttct gaacacagca aaaataccca aacctcgtta actcctcagc 1894081 aggtcagaag ccgtctcgac tatttggaga aaaaagatta tgtcaccaaa agccgcggac 1894141 gcgcaggcac aaaaattacc tttgagggct tgagctttat agagacgtta aaaaatcaaa 1894201 tgatctagcg atcgaaagga gaatgtactt gtttacaatc aaagaagaga tcgccaatgc 1894261 gattacacac ggcatcggtg tcctcttatc catcccagca ttagtgtttc taatcatatt 1894321 tgcggctaat tacgggtctg catgggacat tgtcagcttt acaatattcg gtgtctctat 1894381 gctgctgtta tatttgagct ccaccctgct tcacagcatc acacataaaa aaacgaagga 1894441 cattttggag attattgatc atagcgcaat ttacgtactc atcgccggaa cctacacgcc 1894501 ttttttgctt gggccgctga aaggcacact cggctttacc ctgttggtta tcgtatggtc 1894561 acttgcccta ggcggaatcg tttttaaaat tttctttgtg aaacggttta tcctattgtc 1894621 aaccttcgtg tatttagtca tggggtggct gatgattatt gcagttaaac ctttatatgc 1894681 ttcactgagc ggagcgggat tcagcctcct ttttctcggc ggcattttat actctgtcgg 1894741 aaccatcttt tacatttgga aaaagatccc cttccatcac gccatttggc acagctttgt 1894801 attgggcggg agcgctgcca tgtttttctg cgtgctcttc tattgtgtaa aggtgccttt 1894861 cctttcgtaa cagtaacaga aaagcgcagt cttcacgact gcgctttttt atgcacgtaa 1894921 ttgtttttca ttggcaggta tataagcttt tgaaaaggac aattcaatgt ctgccggttt 1894981 taagcgttta aaaaacgagc cattttgcat gttatctgtt cctttcgttt ccaccatcac 1895041 caacggaaga tgatagcggg ccgcaagttc tacaggatca atagaaccat ctagtgaaag 1895101 aatcaggctt tgtccctttt ccagctgttt tgtcacatct tcatatacct tttctgaatc 1895161 cccgtctgaa atcacatcca tccgatccag ccattgcccg ataaaaggca agcggaacac 1895221 ttttgggtta gcgataaagc cggccggttc ctcaatatat ccagcaatta aggccagttc 1895281 agccaaacgc aaacggggat gcacatacaa aacaggaccg tgtggtattg gctctggctg 1895341 atggatcgtc acaactgaac cggagatgcc gatacagcct tctaaaaacg cctttggctg 1895401 ttcgtacaca agagccatct gttttttgta tgacagacgg ggatcgagca ttgtttgatt 1895461 aaataattgt ttcatatttt ttaacagcat atacacaata taaaccacta gaaggctgta 1895521 gcgaaccaat taaaatcctc ccgctttaga agaattcttt ttttcataca ttagaaattc 1895581 gtaatcatac gggttttttt cgtctttggt cccctgctca gaagaaacca gcttccaatt 1895641 ggattcatca aattcaggaa agtgacggtc accctcaaac tcgtgatgaa ttttcgtcat 1895701 atacagtctg tccgcataag ggaacaggtc cgtatagagc tgagcccctc cgatcacaaa 1895761 gcattcttca gggcctgaac aaatgtccag tacatccttt aatgaactga caaccgtgca 1895821 tccctgaaat tctgaatccg gcgctgaggt aacgacaata tttttccgat ttggaagcgg 1895881 acgtccgatc gattcaaatg ttttccggcc cataatgatt gaatggcccg atgttatttt 1895941 cttaaagtat gcaagatcat tgggcaaatg ccacggcaaa tcattgtctt tgccgataag 1896001 cctgttggca tccatcgcaa aaatgaatga aatcatacgc tgaccgcccc ttttatatga 1896061 ggatgcggat cataatcctc gatgataaag tcctcaaatg caaagttaaa aatagaatca 1896121 acctttctgg cgaaacgaag ctgcggaagc ggtctaacat ctctttccag ctgcaaattg 1896181 acttgttcaa tatgattttg gtaaatatga acatcaccaa acgtatggat gaactcgccc 1896241 ggttcaagcc cagtcacatg agcaatgatc atggttagga gggcataaga tgcaatatta 1896301 aacggcacac ctaagaaaac atcggcagag cgctgataca gctgacagga cagcttgccg 1896361 tcagacacat agaattggaa caggcaatgg cacggcggca acgccatttt atcaatttca 1896421 ccaacattcc aggcgctgac gattaagcgt ctggagttcg gatttgtttt aatatcttca 1896481 ataagacggg aaatttgatc aatggtttct ccatcagctc cccgccaaga acgccattgg 1896541 gagccatata caggtccaag ttcaccgttt tcatcagccc actcattcca gattcgcact 1896601 ccgttttcct gcagatagcg tacattcgta tctcctttta agaaccacag cagttcatgc 1896661 gcaattgatt taaagtggag ttttttagtg gtgagcatcg gaaagccttc ccgtaaatta 1896721 aatctcattt gatatccgaa agtgctgatt gttccggtcc cagtccggtc tccctttttc 1896781 tcaccatgct ctaaaacatg tctgcagaaa tccttatact gtttcatttt tttcatcctt 1896841 taaaagtagt cttctagtag tgtaacacaa taaaaaatca tttctgaacc cagaaatgat 1896901 ttttttatag tcagctgacg acaggctttt catcctgttc tttttcttca tcttgcagat 1896961 cctgatgcgt atgtgcaatt ctgctcgccg ctgctgcagc aagagctgcc acaatatcat 1897021 ccaaaaaggt gtgaataccg tctggacttt catcaagttc cttaataatt ccaatcttct 1897081 ctttatccaa ataaccgaaa ttggtcaaac cgatcgaccc gtacacatta acgattgaaa 1897141 gcgggataat ttcatctatg ccgtaaagcg gttcatccgt ttcaacaagg tgctgcagcg 1897201 gttcggggag aagtttctgt tctgcaagct gatcgagtgc aaggcctgtc aaaacagcat 1897261 gaataatttc acgtttgttc aggacttttt ctacattctc catgcaaaca ctgagcggca 1897321 gatttggatt gtatttttcc tgaagttttt gaacaatccg tgcaatatct tctatcataa 1897381 cgccccgttt gttcagcata tcctttgtta tatcgaccat ttcattcatt gtgtactttt 1897441 tcatgtctaa tggcatctcc tttaggcact catccagttg ggaggcgtgt tgcggtccca 1897501 gtaaatgctc ccaagctcat gatgtgattg aaatccatct tctgctgtat gataatgaaa 1897561 attaaaccag tagccgtcat gaggcgggtg gtctcttcgc acatggaatc tgagaagatc 1897621 ttctccagtt gtccgattgt aaacgttgaa aattttttcc gttttgcccg ctgaaggcat 1897681 gcttgagatc acaacatctt ggtacgcctc atcatcttgc aatgtcgcta aataatcact 1897741 aatcacattt tcgatttttg gcaggatctc tttccgatag tcatcctcaa tgacaggagc 1897801 gattctgctg ccgaatttta aaaaggactg atcctcagcg ctgtcaagga gctgttcctt 1897861 gtacgattga aaaagcagtt caggatctcg cctgtcatcc gactcatcat cgtacaggtc 1897921 atgctcatca taaaaagcgg tgtaatcatt ctgctcaaga ctgctcggct gtccggaagg 1897981 cttgtccgcc ataagggcag ccggaggaga tacgagcccg aacgttacaa tggtaaataa 1898041 aaccacaagg gtctttctca tccacaattt catgactgct tattcctctc tattttattg 1898101 tcatgtttct cttattttag cacatccaaa acatgcaagt catgtactat atgaaactga 1898161 tatgcaaatt aggagattcg ttgctatgca ctttgtgtaa aaacgcttac aatatttcat 1898221 gaaaggaggc tttccgcatg attgacgctc tgtttgccac agtttcactc ttaacattat 1898281 tatactttgt cgtcatggag gtcaccgatt aacagaaagc ccgtgatatg aatcacgggc 1898341 ttgtttgaat gacgccataa tggaacagtg ctgtttttct tttcatgacg ttaaaaccaa 1898401 actgttcaaa ccgcgggctt ttccagtggt cttttagcac aacgcttttt ctggcgactc 1898461 gtaccgcttc attgatacat ccttcgtgca aaacggaatc ctctgccaaa tcacgtaaag 1898521 gcgcgatgcc gtcagaggtt tctacaggtt catgaaacat tggatcgaaa taaaccacat 1898581 caacagagtt gtcagggagc tgcttgatgt gttcaaagca atcaccattc ttcacctgga 1898641 ttcttctcat cgcagcttga agctcttcta tacccgtttc ccatgaatgc agccccgtcc 1898701 tcactaaaac agacacaaga tggttttttt caatcccaac aacagaaccc gtttcgccta 1898761 ctgccatact tgcgataatg gcatctgacc ccaacccgag tgtgcaatct aaaaacgtat 1898821 ccccttcaga taagccggca gcccgaagca taggttcttt ctccccctgt aagaagcgtt 1898881 tggctctgaa catcgctgta ttcggatgaa aaaagaattt ggcaccttgt ttcgtataca 1898941 gctcaaaccg ctctttgccg accacaagca aatcacgttc agctgatttc agcaggtgct 1899001 caaccgtttg tttattccgg ccgcagtatg gcatatttag ctctttagaa agctgctttg 1899061 cagtttttat ggtgtgttca gacggtctat agcttgttgt tatcatcttc tgtactccca 1899121 aaaagaaaat gcccggagaa cgggcattta gcagtgcgca tcgaaggcag cagtcagatt 1899181 tttcatgatt tcttccatat cgtgtccttc aatttcatga cgcggaataa aatgtacgac 1899241 ttctttgcct ttcaaaagag ccattgatgg tgaagaaggc tcctggccag taaaatactc 1899301 acgcattttc gcagtagctt ctttatcttg gcccgcaaat acagtcaccg tattgtcagg 1899361 tgttttgtca ttctggagga ctgcctgtgt agccgcagga cgcgcaaggc ctgccgcgca 1899421 gccgcataca gagttaacga ctacaagagt tgtgccctct gccttttcca taaagttttc 1899481 tacttcttcc gctgttgtta actcttcaaa acctgctcca gtcagctcgc ggcgcatcgg 1899541 tacgacaagc tggcgcatgt attcttcata agccattgac ataaaaaaag ccccctctag 1899601 tatccttcat ctgaagtaaa ggatactata gagagggccg gatttcaaat gttcacgcct 1899661 taaaataaaa gaaagtgtcc ccagctatct agattttcat aataccgccg gtgttggcac 1899721 ttgtcacaag tttagaataa cgtgccaggt agccggtttt cactttcggt tcaaaacctt 1899781 tccagttcgc ttttcgtttt tcccactctt cttctggcac ttgtacatcc aagatgcgtt 1899841 tttcaatatc aacgataata tggtctccgt tttcaacaaa ggcaagcggc ccgccctcag 1899901 cggcctcagg tgatacgtgg ccgattgaga ggccacggga ggctccggaa aaacgtccgt 1899961 ccgtaatcaa tgccactttt ggcccgagtc ccattccaac gatttgggat gttggcgcca 1900021 gcatttccgg catgccaggt ccgccttttg gcccttcgta tctgatgatg acaacgtcgc 1900081 cttcttttac ttttcggttg ataatgccgt caagcgcctc gtcctgagaa tcgaatacga 1900141 cagccggccc ttcgtgtctt gtaatcccat tctgtacgcc gcctgtttta atgatagcgc 1900201 cgtccggagc tagattaccg aataaaacag caaggcctcc cttttcagtg aatggttgat 1900261 ccagcgggtg aatgacgtca taatccttta cttcatgtcc ggcaatggtt tctccaagag 1900321 tttttcctgt aacagtcagc gcatctaaat gaagcgctcc ttctttcttc gaaagctcat 1900381 tcagagccgc tgaaacgccg cccgcttcgt gaagatcttc aataaacaca tccgatgcag 1900441 gcgccagctt agccaagtgc ggcacgcgct cagcgacttc gttaatgcgt tctaaagagt 1900501 attcaacgcc ggcttcgttt gcaagggcaa gggtatgaag aacggtattt gtagaacctc 1900561 cgagcgccat atcgagtgca aacgcgttat caatcgcttt tactgtaaca atatcacgcg 1900621 gtttgatatc tttgcgaatc gtttccatta attgcgcagc cgattttctc acaaactctt 1900681 tgcgttccgg agatgttgcc agaatggttc cattacccgg caaagcaaga ccaagtgctt 1900741 ctgacagaca gttcattgag ttcgccgtaa acatgcctga gcaagacccg cacgttgggc 1900801 atccgaactg ctctagttct tgaagctcgt tttcgttgat tttccctgct tggtaggcgc 1900861 ctaccccttc gaatactgag gaaagggaga tttttcgccc gtcacttgtt cttcctgccg 1900921 ccatcggtcc gccgctgaca aaaatcgtcg gaatgttgat gcgcattgcc gccataagca 1900981 ttcccggtgt gattttgtcg cagttcggaa tacagaccat tccgtcaaac cagtgtgcgg 1901041 atacaaccgt ttccacagag tctgcgataa tttcacggct tggcagcgaa tatctcatac 1901101 cgatatgccc cattgcgatg ccatcatcta ccccaatggt attaaattca aacggaacgc 1901161 cccctgcttc tctgattgct tcttttacga ttttcccaaa ctcctgcaag tgaacatgac 1901221 cgggaacgat atcaatgtat gaattacaca ccgcaataaa cggcttgccg aaatcctctt 1901281 cttttacccc tgctgcacga agcaaactgc ggtgcggagc tctatcgatt ccttgtgtga 1901341 tcatattact gcgtaattct gccatggtga tcctcctaaa ttctttcaat tgtttgattg 1901401 gattttattt tgacaatttt cagtttattt atgggctgtt tttgcaaata agataaatac 1901461 aggccgccct caccttgttt tgttctttcg tgtttttata tttatatagc tttctttcga 1901521 tttgaaccct ccaactatta atattgttac ttactataaa tagttttcgg atatttttca 1901581 acaatattcg aaataatttt tataaaaagt gaattcacat aaaaaaggtg catgatctgc 1901641 acctttttta tctttattcg cctttttttc tgctttccgt catttgtttc caaacagaac 1901701 cttttgcttc ttctccatgc tcaatacgtt caagcgccat tttgacttga aggctgacct 1901761 caaattcggg gtcatcttcg gcagcgcgca aagcttcaat tgcactttca tcgccgactt 1901821 cgtacaggaa catggcggca cgccagcgaa caagcttgct ggagtcgctt aatgacttga 1901881 tcatagcagg aatggcttga ggatcgccga tatcagacag gcagtctccg gccgttcttc 1901941 tgactgatac agctttgtcc tcaagtgctt tatacaatag aggaagaaca tcaggtgttt 1902001 caatcattcc taagtacaca acagcctgtc ttctgatgga cacctttgga tcatccaatg 1902061 ccttctgtaa aaccgggata tcctcttctt tcggatccat ctgttccaag tgtgcataac 1902121 gctttttcca gtcctcatca tccagcatat caagcgttac tttatacgct ttgcgctgta 1902181 cagcttgttt tgcttcgccc tttccttgag cggctgcttc agtcagtcgt ttcagccgtt 1902241 catcactgta tgccgcttga agctcttctg tcacatcatg gccgatttca tcaaagtcac 1902301 cgaatctgac accttgttct ttccaagccc gctcaaacac aacattggaa gcttcagatc 1902361 taagttttaa gatcgcctgc tgaaagcgtt caggtaagcc gaagcgttct tcccgctctc 1902421 catcggttaa tttaacttgc ataggaatgc cgctgaacat ctgcacaaaa acttttacct 1902481 ctccaaaaga ttcttgatca gaacgatttt cttctgcgct ttcagcactt tccatcccaa 1902541 atgcagtgcg gacttgcggt aaaatgtctt tccagtcgta tcttgcattc cgttcaacag 1902601 caagaaaatc tgcgacgtga tatacccctt taactccatc tattttaagg atttccgcta 1902661 taacaagcgg tgcgccttct gcttgctcag gtttatagtt attgcttttg cccgccggaa 1902721 gctcttccgt taagatgact ttcattgtat tcgggcttgg tgtaggttca attgatttta 1902781 tcttcatgat cgtcctccta tagcatatct gtgacttatt ctatcatagt cgctccaagc 1902841 cttctattac gacgtttcgg catcaatccc gggtatgtct ttttctaatt ggcggacaaa 1902901 ttgaagcata aaattgtgtc tttcttctgc cagttcccgt gcagtgtctg tattcatcat 1902961 atctttcagc cgcagcagct tatgaaaaaa atgagcgtag gcgctttgct catctccata 1903021 aaggccatgc ccttttgcgc ccgcaaacat gaaagctctc gcaatgccga cagcaccaat 1903081 cgcatcaagt ctgtcagcat cctgtacagc ttttccttca attgagagcg gctccttcgc 1903141 caatttcccc ctgtcccgaa aggacatcct tgttataata tgaatcaccc tgtcagcatt 1903201 ctcttttcct actccgaaaa aaacgagctg atcatatact tcgctcacag aaagcctgac 1903261 cgtgtcaggc agcttcacat caattaaatc atgaaccaaa gccgccgttt caacaatgaa 1903321 caaatccgct ttttcctttt ctccaatata cgctgcaaga tctgctactc ttgatacatg 1903381 atgccagtca tgtccagagc tttcgtcagt caggatagat tgaacccatg tcctgatttg 1903441 ctctgcctgc ttcaattcct tcacaaaaac accctctttt tattgctcta atagcttcac 1903501 gatatcgtct tccaactctt tcggatttgt atttggtgaa taacggccaa cgatttctcc 1903561 atttctatcc actataaatt tcgtgaaatt ccacttgatc gccttagttc ccagcatccc 1903621 tttcgcatgt tctgtcaaat acacaaacag cgggtgggcg tttttcccgt ttacatccac 1903681 ttttgaaaac ataggaaatg taacaccgta atttgtttca caaaattcct gtatgtcagc 1903741 ctcttcacca ggctcttggt tcatgaattg attgcagggg aaccctaaga tctccagccc 1903801 ctcctgctga tatgtatcat ataattcctg cagctgcttc aattgggaag taaaaccgca 1903861 cttacttgct gtattcacga tcatcagtac ctttcccgcg aaaggctgaa gtgtcatgtc 1903921 tttccctgtg attgtacgta ccttcatatg ataaatagac atgtaagtcc ctcctatgtc 1903981 cttggtgctg attattttac cttttttaaa tcgcaattca aaatgtaaac atcaattaag 1904041 aactcataag aaacctaacg atatgagcgt cagttcatta tcaattcata tggctcgttt 1904101 tttatcttat cattctataa aacattacaa ttccctctta catctttgaa aatcatttta 1904161 ctgtgaaacc aaaaggcgtg tcagtgcgtt ttatttaaag agttttctgt tgtttccccc 1904221 tcaacacgta tagatagatt gaaaattggc gtgaaaattc ctataatgaa gaaaattaaa 1904281 cggggaaata atggaggtgg cacgttgcct attaatatac caacacacct gccggcaaaa 1904341 caggtgcttg aaagtgaaca tatatttgta atggatgaaa gcagagcatt tcatcaggat 1904401 atccggccgc aaaaaattat tatattaaat ttgatgccga aaaaaatcca aacagagact 1904461 cagcttctca gattgcttgg aaattcgcct ttacaggttc atttcacatt tttaatccca 1904521 agcacacaca cgccgaaaaa tactgcgaga gaacaccttg acgaatttta cacgactttt 1904581 tccaatatcc gtcacaagag gtttgacggc atgattatca ccggtgcgcc gatcgagcat 1904641 ttggcgtttg aagaggtttc atattgggaa gagctcaagg aaatcatgga gtggagcaaa 1904701 acaaatgtca cttcaacctt gcatatttgc tggggtgctc aagcaggttt gtattaccat 1904761 tacggtgtgg aaaaaattca aatgccgaaa aaaatcttcg gtgtgttcga acataccgtt 1904821 ctttcaaaac acgaaagatt ggtaagaggt tttgacgagc tatactacgt gccgcattcc 1904881 cggcatacag atataaatat ggaacagctt caagcagtgc ccgagttaaa cattcttacc 1904941 gcatcaaagg aagccggggt ttgcttaatt gtgtctaaag acgaaaaaca agtctttttg 1905001 acagggcacc ctgaatatga tacaaatacg cttcttcaag agtatgaaag agatttggaa 1905061 cgaaaccttt ctactgtcga ggcccctaaa cattattttg caaaaggcag caacgagcca 1905121 gtgaatcgct ggaaagcgca tgccacatta ttgtttatga attggctgaa ttattacgtt 1905181 taccaagaaa ctccttatga atgggactaa tttttctttt tttagtgata cgctgagcaa 1905241 aaaatatgat aaaatacatc tgattcagtc tgcgtataac aaaaatttaa aatactggaa 1905301 tccaaatcat ttaaaattag cttaactttt tcactgcatt aataattcga ttatgtattt 1905361 gtgttatgtt tatgtataga caataactcc ttacgatgca tgaagcttgc ttgttgttga 1905421 ttacattgag gtgaatttac ttgaatacca ataaaagagt attaattttg actgcaaatt 1905481 acggaaatgg acatgtgcag gtagccaaaa cactttatga acaatgtgta cggctcggct 1905541 ttcagcatgt aacagtttct aatttgtacc aagagtcaaa tccgattgtt tcagaggtaa 1905601 ctcaatacct ttatttaaaa agcttctcaa tcgggaaaca gttttatcgt ttgttttatt 1905661 acggagttga caaaatctat aataaacgta aattcaatat ttactttaaa atgggtaata 1905721 aaagattggg cgaacttgtc gatgaacatc agcccgatat tattattaat acatttccga 1905781 tgatcgtcgt gccggaatac agacgccgaa ctggaagagt cattcctacc ttcaacgtta 1905841 tgactgattt ttgtcttcat aaaatttggg ttcacgaaaa cgtggataaa tattatgtgg 1905901 cgacagatta cgtgaaggaa aaactgctgg agatcggcac tcatccaagc aatgtaaaaa 1905961 tcacaggaat tccaatcagg ccgcaatttg aagaatccat gcctgttggc ccgatatata 1906021 aaaagtacaa tctttcacca aacaaaaaag tgcttctgat catggcaggt gctcacggtg 1906081 tattaaagaa cgtaaaagag ctgtgcgaaa accttgtcaa ggatgaccaa gtgcaagtag 1906141 ttgtcgtgtg cgggaaaaat acggctttaa aagaatcttt gagtgcgctt gaagcggaaa 1906201 atggtgacaa attaaaagtt ctgggctatg tggagcgcat tgatgagcta tttcggatca 1906261 cagattgcat gattaccaag cccggcggca ttactttgac agaagccaca gccattggag 1906321 tgcctgtcat tctgtacaaa cccgtgcctg gccaggaaaa agaaaatgca aacttctttg 1906381 aagaccgcgg agctgccatc gttgtgaacc gtcatgaaga gattctcgag tcagtcactt 1906441 cccttcttgc agatgaagat accttgcatc gcatgaagaa aaacattaag gaccttcatt 1906501 tagcaaactc ctctgaagtg attttagagg atatcctgaa ggaatcagaa atgatgaccg 1906561 ccaaacaaaa agccaaagtg ctatcgtaat ggcgtacttg agagcatacg aaaatcgtgt 1906621 gctcttttta tttatattca gccatcaata aaagcggtta cattttttta tggaacttgc 1906681 ccttcttttg aaaaataagc cgtttcgcaa cttgacgggt gctcccagat ggtgtatagt 1906741 tgaaccatca tttaacaatg aatcaaagtt agatgatgac aaaatttttt ttagcacatg 1906801 ggtgctacag tactaggagg aattaagcaa tatgcaaaac ggtaaagtaa aatggttcaa 1906861 caacgaaaaa ggattcggct tcattgaagt tgaaggcgga gacgatgtat ttgttcactt 1906921 cacagctatc gaaggagatg gatacaaatc attagaagaa ggacaagaag tttcttttga 1906981 aattgtcgaa ggtaatcgtg gacctcaagc ttctaatgtt gtaaaactct aaactcaata 1907041 catgatgatg agatgacaaa tagaggagag gcattcgcct ctcctatttg attttcatct 1907101 ggatttcaat cgccaaaatg ttttgtttac acctctgttc aatctcttca acatactttt 1907161 ccattgatgg ttttcctttt ttcgcgatat cggccagttc ttctaaatca ctgtatattt 1907221 ctataaatgt tttgtgaagg atcaacttca agtctttatc atccatagct gcgttcccct 1907281 tctctatcaa gatacctcaa atagtaaaac ggtcctattt attctggttc aatagttata 1907341 tcggcttatt tttattttct tttctatttt ggtacataaa tttcaaaaaa actctgcaaa 1907401 ataatggcgg aggtgttttt tgtgacttca gaatttcata atgaggatca gaccggcttt 1907461 acggataagc ggcagctgga actagcggtg gaaacagcgc agaaaacaac aggagccgcg 1907521 acgagaggcc aaagcaaaac attagtcgac tctgcatacc aagccattga ggatgctaga 1907581 gaactgtcac aatctgaaga gctggcagct ctcgatgatc ctgaatttgt aaagcagcaa 1907641 cagcagctgc tagatgacag cgagcatcag ctggatgaat tcaaagaata aaaaccgcag 1907701 cttctgcggt ttttattttt agtgattggt taagacatct ccgtattgtt tcaacttttc 1907761 accaaccgta catttattga tacaaaatga atgcgcataa gttttgccaa attctttgcg 1907821 aaactgcttc ttaataaaac agtccttgca atattcatcg tgcagttctg tcagttcttt 1907881 aaagatcatt ttcttatcca atatcgtcat ctccgttacg gtctaatttc gtgtggcttt 1907941 ctacgaattg atgggataga atttttttag cgaggccgtc agcttcctga ttgtcttttc 1908001 gttgtattgt ttcgtaggtt ggagtaagct tcagcgattc aaggagtgct tctattttgt 1908061 ccagccattc attatgagat ggatcataac aaggccagct gccgtcaagc tgattcagca 1908121 caacaagcga gtcccctttg attgtaattg aatttctgct tgccccaagc tctcttactt 1908181 ctcttattgc ttcataaagc gctgcgtatt cagcttcatt attggttttc agccggaagc 1908241 ttttattttt tctcaagcga tgccgggttc ctcccaatga ataatagatg acgatcccga 1908301 gaccggccag ttcgctctct ttatcgaaac tgccgtcaaa ataaacagta atgtcatcag 1908361 gctcttgagc aagctcctct gtcagctttt ccaattcctt cagcgtccag ctgccgcctt 1908421 tctcgtcttc gaactctagc tccttcatgt atggaaaacg gccaagttct ctggcgaacg 1908481 tacgtgcctg ctgtgctgtc agccagtctt cgctaaaaaa tgagacggat cccgttcctt 1908541 ttgcttctat tttcaaatgc ggtctgagct tcattacaat caccttacca ttcattagtt 1908601 gccgggctta tgctataatc aaaccaatct taccccggaa aggaagcttt ttcatcttgt 1908661 ttaataattc gttttggatc ttttttgcga tcattcattt tatcattgtt cttttatttt 1908721 ataaaggatt tggcaaaatg ggactgtttg tttggatcgg ttttgcgaca gtctgcgcca 1908781 acctccaagt cgtcaaaaca gtcgaactgt ttggcttaac agcgacactc gggaatgtga 1908841 tgtatggcac aatctttttt gcgacagatg tgctgaatga aaaatacgga ccagctgaag 1908901 ccagaaaagc ggtatggctc ggattctcaa cgctcctgac gctgacattt gtcatgcagg 1908961 gcgtgctgct tttcgaaccg gcttccagcg acatatcaca aacagcgctg gaaacgatct 1909021 tcggattcct tccgcgagtt gcgttaggaa gtctgcttgc ctttatcttc agccaaacgc 1909081 tggatgttta tgtatattcg gcaattagaa ggatatttcc ttctgatcgg cttttatggc 1909141 tcagaaacgg cggcagtaca gcagtcagcc agttgtttga tacattcata ttcactgcag 1909201 tcgcctttct cggcatttat ccggcagacg tgtggcttca tatttttatt tctacatatt 1909261 tgattaagtt tgcggtatct ttaatttcat tgccttatgc ctatgcagcc aaaaaaatga 1909321 tacctaatga tgaaaggagt tcataatgcc tacagaaata tatgtagacg gcgcaagcgc 1909381 cggtaatcca gggccttccg gtatcggcat ttttatcaaa catgagggaa aagcagaatc 1909441 tttctctatt ccaatcggag tgcatacaaa ccaggaagcg gaatttcttg cattaattga 1909501 agggatgaag ctatgtgcaa cgcgcgggta tcaatcagtt tcctttcgaa ccgattcaga 1909561 tattgtggaa cgcgccactg agcttgaaat ggttaaaaat ataacgtttc aaccgtttgt 1909621 agaagagatc atccgattaa aagcggcatt ccctcttttt ttcatcaaat ggataccggg 1909681 caagcaaaac caaaaagccg atcttctggc aaaagaagcg attcggctga atgaaaagaa 1909741 ttaaatcttg atcattggtt catcctaatg gcgaggtgaa ctaacatgaa aaagaaagat 1909801 aaaggccggc tgaccggcgg tgttactccg caaggcgacc tggaaggcaa tacacataat 1909861 gaccctaaaa cagagcttga ggagagagca aaaaaaagca atacaaaacg ctagagagga 1909921 tctaaacgat ctctctagcg ttcagctttt caagcatacg ctcaattcct ttaatttggt 1909981 ggcggcgaag catgtcagcc gcctgctcca tttgcaaagt aaataaagcg tctttcagtg 1910041 tgcaggccag cggcactgag caatggattt ccgcaagctt cctcgacatc tccaaatcgc 1910101 ttaaaccttg ctgaattttt ccctgctgtc cttttggaag aagagaaaga ttttccaata 1910161 aacggtcaat cgtttcgtat tcacgaatca gtttgtaggc tgttttttct ccaatgcctt 1910221 tgactccggg atagttatca ctggaatcac ccataagcgc tttaatatca atcaaagcct 1910281 tcggcattac gcctgtttct tcataaaaag tctcttttgt atagacttta taatttccga 1910341 ttcctttttg aagcaaagca acgcttactt tatccgttaa cagctgaagt aaatctctgt 1910401 cccctgttac caccgtaatg tccgcttcat tcgcaaataa atcggcaaga gtaccgatac 1910461 agtcatccgc ttcatagccg gcaaagccaa tattcatgat tccaagctct gcggctgctt 1910521 cctttgccaa atcaaactgc ggaatcagct ccacaggcgg cgcgctgcgg ttggccttat 1910581 aatcttggaa caagtcattt cggtacgttt tgctccccat gtcccagcag cagacgacgt 1910641 gtgtcggctg gaatgtttcc acagctgtaa tcaaatgctt taaaaagccg ttgacgccgt 1910701 tcgtcggcac cccgctgtca tttatcataa agttgcgatg tacggccgtg gcaaaaaagg 1910761 cccggaataa aagagccatg ccgtcaacca gcaatagttt attattattc atcaaataac 1910821 tcccttttct ttcattcctt ctattttatc ataaagcagc ccaaaaataa aaaacagtat 1910881 ctctttaatt agagatactg tttgaatatt tatcaatcgt tgtgtctttt gttgctggcg 1910941 atcagctttt cagcttcgcg tcctgcgtaa gagtcaaaat gggtttgaaa tccgtttttc 1911001 tttttggcgt tgttattcgc ctgtgcattt ctgtttccga gctttgttct gcccaacatg 1911061 aatcccccct tacgtcggat gcatatagta tatgcttccg gcaggaggtt cactcgcgac 1911121 aggatcatcc agcttacatg cggcttacgt attctctgac catttctttt gatacaagcc 1911181 gtcttgtcgg gacgatgcct tttttagcga gctgattcat ttgctcggta atttcattaa 1911241 ttgcatctgt agtataaggc tcatcgtttc tgcatttagc aacagcttct tcaatcgcca 1911301 attcacgcat attttcaaga cgcataaatg ctttgatatg ctcgtgctgt tttgatgaat 1911361 gtgctgaaat tgctttatgt acctctgaca ttaatcgttc atctcgcttt tttctattta 1911421 gtctatcatg acttgaaata caagccaact gaattttaca tttttattgt attgtctgaa 1911481 tttttccagg agatgcacgc ctgatacgcc atttcaatct ctttcgcatg ttccccttcc 1911541 gcatatcctc ttaaatatgt ctctttttga tccgttattt gcgcgattgc tttttcaccc 1911601 atatcttcct gtaagcgtct gaggtgagca gtgtaatgag atatcaggct ttcttcttca 1911661 ttttttatcc atgcctctgt gattttcgta agtttcatcc gtacagcttc gataaaggtc 1911721 gcttttcctt tctgctcaaa aaactgcttc ggtgatttga tctcttttag ttcctgctca 1911781 aaagcacgtt cttctatttc cggttcaact tccttcaact gtatgccgtt cgaatgctga 1911841 tcacccgcat aaacggaaaa ataaccgtcc tcgtttaatg ttttttgaaa atgatccagc 1911901 cattcttcat tgatatgccg ttcgatgaaa ccgctcatgc gaacatcaag cgttttgatt 1911961 tcctgaatat attcaaatag atattcatgt aaggctgttg tcatcgcttt actgacgttc 1912021 tttttccaat ccccgttttg cagcccggga tgaaatgccg attttaataa atcatttgca 1912081 aaatatgata atcgctgtgc aatgtgatat agctgctctc ttgtatcttt ttttactttt 1912141 tcaatgatgg tttttgagtt ccgccgtttc tcgatatcgg ccgctgtccg ctcaaatgac 1912201 agcataaggc actgtttctg cgcttccttc tcttctcggg actgatgctg ggattggtga 1912261 agctgaaaaa cagtttcgca tagtttgtct gcctccgaac tgagctgcgc tgctgacgct 1912321 ttttttacat ccacttcgat aaaccggtct aagtgttttc ttactttcga gaactgatta 1912381 taaaatgact ccggttttcc caccagttcc tccttacttg atacggtaaa gagctgcggc 1912441 tcataaaccc cttcttttac aagctctgcg ctgacataat cggtcactgt ttcgagctct 1912501 gttttatctt ttgcaaggtc tgcagcatta ataataaaaa acattttatc catgctgagc 1912561 gattctttca caagtccaag ctttcgcaaa aatgaacggt ctccttttga aaaagagtgc 1912621 tgataataag tcatataaaa aaatgcatca gcatctttga tatattggaa tgccagttct 1912681 gtatgccgtt tattcatgct gctcgcgccg ggtgtatcaa cgatcgtaat ccctttttca 1912741 gtgagcgggc atgtatagta gaccgttacc tctttcacag cacaggccgt tgtttcctct 1912801 gctacatacg gctttaattc agagagcgga atcgttaatt tcttctgttc ctgtatatac 1912861 tgctgatact tctcgtatgc aagcaggaaa ttgctgatca atttcacgtg ttcttcctgc 1912921 agcctgtttt ttttgactgc cttttcccac ttctctgtga aggaacggcc tgccggctcc 1912981 tttggtattc cggtgagctg caaaatttca gccgttaagt catcctctgt cttaaacact 1913041 acattcgctg ttttgtttaa gttgccattg attggctttg tgatcttgtt aattgtcgct 1913101 gtggttggcg ttggtgagga tggcagcact ctttcgccga caagcgcatt ggcaaatgat 1913161 gatttccccg agctaaagcc tccaaaaaga gcgagtgtaa atttccgttc ctcaagcctt 1913221 ttcacccttt cacgaaacgc tgaagtttgc tttaacaaca tgctgcattc gcctaaaatg 1913281 tcagacaaag tgtaaaagcg tttgatttgg tcttgaagcg gcatttcttg ttccattttg 1913341 atttctgatt tcggcatcgg ctgcgccgtc agctggcttc ggccttgttt ctgctctgga 1913401 gccgccactc ttgttttctt cgatttaaac cattctgtgt ctatatgcat tgggcatgcg 1913461 gactcttctt cccaaatggc ccacaggcga tcggttttct ctcgggcatt attctctaaa 1913521 cgtgcctgtt cttgaagaaa gacaagtttt tctgattctt ggacgagccg gtcgttaatt 1913581 gtttgcacat ctttggaaac acgctctttc accatagcgg agagcacctt tatgatgtct 1913641 gcggcttctc ttttcgcctc tttccggatg agctctgcca agtcttttgt atattgcaat 1913701 acatattcag aggaaaaggc tgcaccatgc ttgaccgcgt gttcaatgat gcttatatca 1913761 agcggtgtgc gataggcctg aatcagcttt tcactttcag cggtatagac atcaaatacc 1913821 ttggcgagtt tatgaagcgt gtctatcata tgccaatccg cttcggcctc tgttcgtttt 1913881 gccacatcag agaaaaaagc attccgcctt ttatctcttt cctgtgcagt tttcgcttta 1913941 gaaaagaaaa agccggtttt aaaggaaggc tcttgtgatt ctaaaaatgc agccgccaat 1914001 tcacgcattt caaaaggcgt caggttggcg ttttttaaaa tacgattgat ttcttcctgc 1914061 atcctcttct ctgcctcagt catttgtttt tcggcctcat ccaattgatc acgcagcgat 1914121 tggaccagtc cagtatggat attaagctgt tcagcgaaac tcggagcgcc tgtttcgtct 1914181 ttcttcagca tttccgtatg ttcctttagc agattacgga ctttttgttc ggttaaagcc 1914241 tgcatattgc tttttgattg ctgttctatt ctgcttaact cttctctcag ggcccccatc 1914301 tgattgaacg ggtgatccgg ttctgttact gatgtaaaat agagcgcttc ccttgaaatc 1914361 ccttcattgc aaagcatctc ctctacctgc gcttgatagt ctccaaattt cgtctccgtc 1914421 tcatcatggc ggtcaatttg attgacgata aaatacacat tcggaatgct ttcttttatt 1914481 gatctgagaa actttacatt ttcctcagcg tgcacgtgat tatagtgaac gacgtaaaac 1914541 agcgcatccg cttggtgaag aatagaagca gccgatagaa aatgcgcatc atctgttgaa 1914601 tctatccctg gagtatcaat atacgcaacc ccggaatcga tctcagtata cctgtcaaaa 1914661 atttcgacgc tttcaatctg ttccccgtct ttacaatatt gctgcacctt gtctttctgg 1914721 taagtccctt ccagctcagc acacgctccg tctgttgtat gaagccgaac tcgcttttcc 1914781 ccgtttctga tcacaacaag gttagcgctt gtcggaatcg ggcttgtcgg caaaatattc 1914841 tccattaaca ggcagttcag cagtgacgat ttccccgctg aataatgccc ggtaaacgcg 1914901 atataaacct cttcatcagc cgcttttttc atgaccgcag ccagtttagc agccctttgt 1914961 tcatcttgat tctcaataaa ttgcttataa agttccccgg ttttatgcaa aagctctttt 1915021 ctgttttgat ctgtcataag tctgaacccc tttgtgccgt ttcaattgtg aacctttttc 1915081 gaaagatctg aattcattcc cttttcattt tacacaagaa taaaccaaat ttctttagga 1915141 gaatagaaaa aagccgccat tacggcagct tctataaaag aaaatctgca acttttacaa 1915201 gttccagatt catcaaacag atttattaga gattcctttt aatacaaaac caattaatac 1915261 actatatgta caaaccgctc caagcaaaaa cagcattgtc atttgcttca ccatcctgat 1915321 tgagaatctt tttcaaaccc attttaacat ggttgagaat gattttcaat cgctatttta 1915381 cgctgtattc ctgtaatgct ttgtcttctg cgcgaattct gacgcttaac aacacggcat 1915441 tgaaaatgga aaacagacac atggtgacgt atgcttgata aagcagcgga atcagcaaaa 1915501 tttcgaggat aacaacggca tagtttggat gtttcatcca tttatatgga ccttttttta 1915561 caagctctac acctggaaca acaaggattt tcgtattcca atatgctcct aaggaacaaa 1915621 gcgcccaata ccgtacgatc tgtacgctta aaatcactgc agcgataccg agccaccagc 1915681 tggacggctg tttattcatc agcagcacct cggcaattaa ggacaggaaa aaaaggatat 1915741 gcatcgtaat gatatacgga tagtggctct cgccaaattc aattgctcct tgcttcttta 1915801 ccttttgttc gttttgcctg gccactgcca tttctgctgc tctttgaaca atgagaatgg 1915861 cgatcaacaa ccaaaacatg agtcaggccc ccttttccca gctgaataat agcaactctg 1915921 atgagaaacc cggccctaat gcgccaatca gtcctcgttc agcttccttt ttatgtccgt 1915981 tctgcagatg gtctttgatc acatacaaga ttgtggctga agacatattt ccgtgctttt 1916041 gcaaaatgct ttgcgcagat gaaagctttt ctgacgacag cccgagactt ttgatgtatg 1916101 catcgatcac tttttttccg cctggatgcg ccaaaaaaac actgatatca tggaatgaca 1916161 gcttatgttt gtccaaaaaa atctgtacat ttgttttgag ccatttttcc accaaggtcg 1916221 gaatgtctcg tgagaaaatg actttgaatc cttgatcggt aaagtcccag cccatgacat 1916281 cttctgattg tttcatcaaa acagattggg cgtccattat cttcggcgca agcttcagct 1916341 ttgacaccct gcggtccgcc ttctctccgc ataataaagc tgcggcaatg ccgtcaccaa 1916401 aaagcgaggt gccgatcaga ttgctttttg ttttatcttc cggctggaat gtcaggctgc 1916461 acagctcggc agaaatgaca agcacaaaag cctcaggata cgctttgcag tattcggctg 1916521 cacgcgcaag tccgctggct cctcctgcac agccaagccc ccaaatcgga atccgcttcg 1916581 tatatggaga aaacggaagt tcattcataa gccgcgcctc gatactcggt gtggaaagac 1916641 ctgtactgga gacgaaaaaa acagcttcca ctttctcata aggaatggct tcttgaaaaa 1916701 attccggatg agagaggcac tcacgaacag ccgctctgct gtgtttaagt gtttcttcta 1916761 tgtatatttg atttttttct tcaaagctgt gcccctcttt ataccattca atcggcttaa 1916821 caaactgtct cgaatggatt tgcccgtttt taaaggagga taacagcctg tcaatatcct 1916881 taaaagaatg ctgaaacata tagcgggcga actcggccgc tttctcttgg tttacattat 1916941 acgcaggaag acttgttcca atggataaaa taaacgccat gcgatcacct ctttgcatac 1917001 attgtgccgc aacaatcttt tttatatgca aaaaaaactc cgccgcggcg gagttagact 1917061 gctgtttttt gttcagcgag gtcagcttct tgttctattt ttttagcttt agaaaaaacg 1917121 ttatatacaa tatttaagac gactgcagta aagctgcccg ccacaatgcc attcgttgta 1917181 agcagcgtta aggcactcgg aagctgtttg aaaatatccg gcacaacggt cacaccgagc 1917241 cccaatccca ctgagcaagc aacaatcagc agattttcct gtttcgcaaa atcaatgcgg 1917301 ctgagcattt taattccgta agcaatcacc attccaaaca tcgccaccat tgcaccgccc 1917361 aaaacagcgg atggaataat agtcgtgaaa gcagcgatct ttggaaacag cccaaatgcc 1917421 attaggatca cacctgtgac cacaatgacg gcattttttt tgatccctgt gagctgaaca 1917481 agcccgacat tttgagagaa tgccgtgtaa ggaaaagcgt taaaaatacc gcccagaagc 1917541 acagccagtc cttcagctcg atagccttta gacaaatcta tctctgtcaa acggcggttt 1917601 gtcaggtcac ctaaagcaaa gtaaacacca gttgactcca caaggctgac aattgcaacg 1917661 atggacatcg taatgatagg cgctgcgtga aaagacggcg ctccgaagta aaatggctga 1917721 atcatttgaa caactgccgc gtccgaaaca ttatcaaatt gaacttttcc cataaaatat 1917781 gcgatgaagg tgccaatcaa aataccgatc aaaatcgaga cggacttgat aaagcctttt 1917841 gtaaaacggt atagaagcac aatgatactc aacacggtaa aagcaagtgc aagattggag 1917901 agatctccga aatctgcact tccttctccg ccggccatgt tattcatggc aaccggcatc 1917961 agtgtaatac cgataatcgt aacaacagag cctgtcacga ccggcggaaa aaacgatacg 1918021 agctttccaa agaaaaatga aataagaatg acaagaatgc ctgaagcgat aatgctgccg 1918081 taaactgttg aaaccccata ttcagatcca atcgctatca tcggcgatac agctgtaaag 1918141 gtacagccaa gcactaccgg aagcccgatc ccaaaaaatc ggttgctcca cacttgcaga 1918201 agtgtagcca caccgcacat aaaaatatca atcgatacta agtaagtcag ctgctcgaca 1918261 gtcagtccca ttgcttttcc gacaatcaga ggaacgacaa tggcgccggc atacatggca 1918321 agaacatgct gaatccctaa agacagcgtt ttgccgaatc catttctcat gaatgaacct 1918381 cctgtacgaa ggacactttt ccttcttcta aagactgaat tcttgccaaa gattccactc 1918441 ggtagcccag ttttacaagt tcatctcttc ccggctgaaa tgacttttca ataacaatgc 1918501 cgattcccgc aatagaagct cccgcttgct tcacaatcga cacaagcccg tgcgctgcct 1918561 gtccatttgc caaaaaatca tcgataatca gcacatgatc ctgatccgac aggtgggtcc 1918621 cagacactgc gatttggctt tctgtttgct tcgtaaagga ataaacagac gctgtcagca 1918681 agttgtcggt gagtgttaac gatttatgct ttctcgcgaa gacaactggc acacccagct 1918741 tcaagcccgt cattacagcg ggagcgatac ctgatgattc gattgtcaca attttggtaa 1918801 taccgtcttt tgcaaaccta gacgcaaatt catcaccaat tctctgcata agcagcggat 1918861 caatttggtg attcaaaaaa gaatccactt tcaatacctg atcagataat acgacgcctt 1918921 cttcctctat tttccgtttc agtgcttcca tcctgtctac ctccgttatg agaataaaaa 1918981 aagcattgcc cgctcaaata aagagcaagc aatgctgata tcacaaaaaa ccgtacacgt 1919041 gcggttccat tgctcaccca tagtcggaca tttacggtgc ccggtagaaa cttgcgtgcc 1919101 atatccacgc gattatatga gtgttcctat tatattgtaa taaattatat caagattcta 1919161 atctcttgca taggctgaaa ataaaaattc ccgaacttta attttgtttt tttagatatc 1919221 attcgtattt caaggggatt cgatataaaa gagtctgacg accgcgccgc caggcttttg 1919281 attataacag atagagattt gaatatttgt ttgataaata atcaattaaa tagcgaacat 1919341 tcagctcttc tcctgttgca tctttaataa tgtctaacgg ctttttccgt tttccgtgaa 1919401 tgtgcacctt ttccgtcagc cattgcttta tcggatggaa ctctcctctt tccaagagag 1919461 cgtcaaattc agggagatcc tcaagcattt tttgtttcag ctgagccgca tacatgtagc 1919521 cgagcgcata ggatgggaag tagccgaaat ctccacctgc ccaatggacg tcctgtaaaa 1919581 tcccctctgc gtcggtctgc ggtgtaatcc ctaaataatc ctggtatttt tgattccaaa 1919641 gcgacggcag atcttccaca gacacttcat tgctgaaaat cgctttttca atttcataac 1919701 ggatgatgat atgaagagga tacgtcaatt catccgcttc gaccctgata aatgaaggtt 1919761 ttgattcatt gattgcccgg acaaaatcat ccagggagat gtccttgaac tgtacaggtg 1919821 atgcctcttg aatcttctta tagtacggag tccaaaaatg cttgttgcgg ccgataaaat 1919881 tctcgtaaaa taatgattgc gattcatgaa ttcccatcga tgcgccgtct gacaagttcg 1919941 tgccactgag tgcttcatca atattttgct cgtaaatcgc gtgcccgcac tcatgaatgg 1920001 tcccaaagat cgccgtccgg aaatcttttt catcatatct cgtcgtgacc cgaacgtctc 1920061 cccgattcag cgtagttgca aacggatgaa cggtttcatc aagtcttccg ccatcaaaat 1920121 cgtagccaag ctcctgtaaa aaatacagac tgagctcttt ttgcttttct ttcgggaacg 1920181 cttttgtaat aaagcttgta tctggtttat ttccggaagc tgtcacctgt ttaacaagag 1920241 ggataatcgc ttccttcagc tcagcaaaca actgatcaag cacctttacc gtgacgccgg 1920301 gctcaaacaa atcaagcaat gcatcataag gatgctcttg atatccccaa tacgtaataa 1920361 aacgtttatt gaattcaatc agctgttcta aataaggaga aaacaagctg aaatcagatt 1920421 ttcctttcgc ttcctcccac gctgtttctg cctttgaaca cagaatcacg tattctttgt 1920481 attcagcctc agggattttc ttattctctt catactcttt tttcgccagt tccactgctt 1920541 ttttcgtatc ttccgacaag tcatcaaatc gttcatacag gacatcgata agctccttca 1920601 ttcgatctga tgtttggata ttgaatatat ctgttgaaag ctggccgata ctttcggcac 1920661 gatcctctga gccatttttc ggcgcgcctg ttctggagtc ccagtgcatt aacgcaactg 1920721 cttcgctgta atgtgagatt ctttttaaaa gatcaaaaaa ttctttttca tatgtatgta 1920781 tctccatatc cattccctcc ctattctagc cgttccatta caggctaatg gaagggggta 1920841 tgaaagtcaa attgtttgta taaaaggctg ccggtatgtt ttgtggcagc ctttttattc 1920901 agttgatcgt catttgattt tttggcggag gtgttctccg ctttttctgc ttgatttttt 1920961 tatctaccca cactgttgcc agcggggtta agagcgaggt gacaataacg cttgtcgcga 1921021 taattgcagt tgccgactca gcaactggcg caaatgaggc attcgcttcc gctaatgcat 1921081 atggcacggc tacagccgcc cctgccgtag aagaagcggc cactcccgcg acaccatctc 1921141 cccgcgcaat aaaacgatca agcaaaaaca aagaactgcc cgataaaatg acgacagaaa 1921201 ctccgataaa aatgccgagc agccctgatt ggatcagcat tccaaaattc aaggtattgc 1921261 cgagcgaaaa ggcgaaaaat ggaatgatcg ccggcacaac cttgctgaat aagtctctga 1921321 gatcatgatc cagatttcca agtatacatc caagtaaaaa cgggatgact gtcgctgcca 1921381 gcgtttccca tgggaatgcg gcaagtcccg tcacaccaaa cgtcaccatg gtcataaaag 1921441 gaccagattc tgtactgata aaggcgaaag cgcccgcatc ctcttttctt cccatgtgat 1921501 tcatgagcgc caaatacagt ccgccgttcg tttcattcat taccgcgaca attgctaaaa 1921561 cagaaaggcc tgcaaaaaag ccggattgta tgccatcgtc aggtataaat tgcgctgcga 1921621 tcacgccgag cagcgccgca aatccgatct tccccaataa taacgtgatt ccttttcttg 1921681 cgatatagcc tgaagaacga aaatcaatcg ttgctcctac gcaaaagata aaaacaccca 1921741 gtatcggcag cgttccggta atcaaagcac ccgtaaaccc tccaaagaac tccgctgttc 1921801 caggcgcaaa cgtgttgagc gccgctccaa gaaatagcgg aataatcatc attccgccag 1921861 gtacccgttc aattgtcgcc ttgattttca tattgtggat tctcccatcc tccggttatg 1921921 aaaaaacaat tccacttaca cttggaaaac agcctgcaaa tcctcttttg aacagctgcc 1921981 caactggctg ccgactccga cggcgccagc tccggctcta agccaatcag gcacttcaga 1922041 cggatgtatc ccgcctgtcg gaataaaggt cacctgcggg aaaggacccg ctaaattttt 1922101 cataaacgga atgccaaaca caccgcttgg gaacagcttt aatgtcgtaa aaccgaatgt 1922161 cagcgcttcc ataatttcgc tcggagtcaa gacgccgggg atataatgtg tctttacaaa 1922221 agatagatgt tcagcaagat cagctgaaaa acccggactg acaataaact gcgcgccagc 1922281 cttagcagct tccccagctt gctgcgcgct gatgaccgta cccgcgccaa ttaaaatatc 1922341 ttccctatta cggaaggatt cgataatatc tgatgccccg ggggtcgtat acgtcacttc 1922401 aactgcacga atccctttat ctaataaact ctcaatctgc tgacaggcct cctgcttatc 1922461 ctttgaacga atgactgcaa tcagctttgc ttctttcaga cggttttcaa cgactttgga 1922521 ctccatatta ataatcccct ttcttttggt gaaccgttct ttgagcagat aaaaaagaag 1922581 ctaatttctc cctggtcggc aaaccgtcca tatcccccgg tgcctgcact tgcaaagcgc 1922641 caatcgcatt tcccctttgc accgcatcct tgtacgacaa accgtctagg ataccgctga 1922701 ttacaccgac tgcaaatccg tctccggcgc cgaccgtatc aaccacccgg tcgacccggc 1922761 agccttctag aaatccttca cttgtccccg ttttaaagta agcgccttct tttccaagtt 1922821 taatagcaac aaagctggca ccttttttca aataatagtc ggcaatgcct tcaggtgttt 1922881 tttctccggt caatagctct ccctctgcga tacccgggaa aaaccagtct gcaagcccag 1922941 ccagatcatt gattgtgtgt accattgttg cttgatcagg ccaaagcgaa ggtcttacat 1923001 tagggtcgaa tgaaatggtc ttccctgcgt ttctcatgtc gttcatgaca tgatacgtga 1923061 agtctttcat ctcggctgat aaagcaggcg gaatacctgt cacatgcaaa tggcctgcgc 1923121 attgaaaata atctctcgga tattcagctg tagttaatgt gcttgcagct gagtttttcc 1923181 tatagtaggt aacttgcggg tcgccttctt tcacttttga cttcagcagc agcccggtgg 1923241 gattttcgtc ctgcgagcgg atcacgcggg acacatccac tccctctttt ttaagctctt 1923301 gtaaaataaa cgttccgagc tgatcattgc cgaccttgct catccatccc attcgaaatc 1923361 cgagtctggc aaggccgcag gcgacattgc tttctgctcc ggcaagccct ttagaaaaag 1923421 tggatacttc atgaaggcct ccatactcat ttgcataaaa catggccatt gattccccga 1923481 atgtcaccgc atcaagcttc atctcttccc aacctcctct tagttgaggg cacctaggat 1923541 taaagtgact ttctcatgat gacttttgcc tctaattcaa tggtttgagg cgctcctttg 1923601 tcaccttcaa tcctttttaa tacacgttcc atcgccgtcc tgcccatatc atgtgacggc 1923661 tgggcgatcg ttgtaatgcc tggaccgatc agtttgtacc actccgtatc atcgaatcct 1923721 gcaatcccta tatcttgagg gatgcgcagg ccaagctctt ccatacagct gatgattttc 1923781 agcataatca agccattcaa agccagaatc gctttttttt gctccggcat ttccttgtga 1923841 aaagaacgaa gctccgcctt aagctgctcc ttgtccttta cgtcaatttc atgcaatctg 1923901 acaagcccgt tcacattttg aaccgaagcc atttcctgat acacagctgc tctttctgca 1923961 cgagggctga tagaggaaat cggttcggta aacagcgcga catcagtata ccctttgctg 1924021 tacaccttct gaagaatctc ttttgtgatc catctgttgt cagtcgttac ggtatccagt 1924081 ttcagatccg gcagtttccg gtcaattaag attgttggaa tttgctgttc agcaaaagcg 1924141 cggagtacat ccttgttttc ccctgttgcg tttaaaatca agccctcaac cgaatgggct 1924201 tctagcttta agagcatttc ccgctctttt tcaggactgt tatctgtgtt gcacaccata 1924261 atgctgtatc catattgatc acaaacctct tcgactcccc tgaaagcagc gaccgaaaaa 1924321 ggatttgtaa tgtcagccac aacaaatccg attaacttgc ttttttttat tttcaaacct 1924381 tgtgccattt tactcggccg ataattcaat tctgcgattg cctttttaat gtttttcact 1924441 ttttcaggag aaatcgcgtc aatttttccg ttaatatagc gggaaactgt cgatttcgaa 1924501 actcctgcac attcagctac gtctttgatg gttgtatggc ctgttgtttt ctttttcatt 1924561 caagtgctcc tgtatctcat atatttgaaa ccgatttcaa aaccgttaca acaaaagaat 1924621 accataattt taaaatttgg gaagagtttt tttaataata tgtcaattca ttattttttc 1924681 gttgactctt ttcactattt atcctaaaat tttctttgaa accgttacca aaatattttc 1924741 attcaagtga tgctgaaatc ctaaccaagg gggaaatata atggaaaatc gttattctgt 1924801 acatcctgaa caagtaaaac gctttacaac agaggagctt cgcagtcatt tcttaatgga 1924861 ttctttattt acagaaaaca aacttacgat gtattactca catgaagacc gggttgtcat 1924921 cggcggagcg gctccagggc aaagtgaact gaagcttgat gcaggtgatt ttctaaaaac 1924981 agacttcttt ttggaacggc gtgaaatcgg gattattaat gtcggccagc ctggtgccgt 1925041 tagagtcggc gatgatgaat atgtgcttca aacaaaggat tttctctata ttggaatggg 1925101 caatcaggat gtatcgtttt caagcctgaa cggggaaaaa gcgaagtttt acttcgtctc 1925161 cgcttgcgcc cacaaaagct atccgacaca aaaagccgcc ctatctgaac tgacaccgga 1925221 ccgccttggt gatgatgcag cgtctaatgt cagaagtctg tacaaagtca ttcatcagga 1925281 tggcattaaa agctgtcagc tgatgatggg aataacgatg ttagatcaaa acaacaactg 1925341 gaataccatg ccagcacacg ttcatgaccg tcggatggag gcttatcttt atctggatct 1925401 tgaaaaggac tcaaaggtat ttcatttcat gggccagccg gacgaaacac gccatcttgt 1925461 tgttggaaat gagcaggctg tcctttctcc cgcttggtct attcattctg gcgcaggaac 1925521 atcaaactat agctttgtgt gggcgatggc tggagaaaat tacacattta cggacatgga 1925581 tctcattcca atggatgggc tgaaataaga tgggttatct acatgacgcc ttttcattaa 1925641 aaggaaaaac agcgctggtg acaggcccgg gaacagggat cggtcaagga atagccaaag 1925701 ccctagccgg ggctggcgct gatattatcg gcacatcaca tacaagcagt ctgtctgaaa 1925761 cacagcagct tgtggaacag gaaggccgga tatttacatc ttttacattg gacatgagca 1925821 agccggaagc gataaaggat tctgcagctg agctgtttga aaacaggcag atcgacatcc 1925881 ttgtcaataa tgccggcatt attcatcggg aaaaagcgga agattttcca gaagagaact 1925941 ggcagcacgt actgaatgtc aatctaaaca gcctgtttat tctgacacag cttgctggca 1926001 ggcacatgct gaaaagaggt catggaaaga ttattaatat tgcctctctc ctgtcttttc 1926061 aaggcggcat cctcgttccg gcttacaccg cgagcaaaca cgctgttgcc ggtttgacaa 1926121 aatcatttgc aaatgagtgg gcagcgtcag gtattcaggt caacgcaatc gccccaggct 1926181 atatttctac tgcgaataca aagcctattc gggatgacga aaagcgaaat gaggacattt 1926241 taaagagaat tcctgccggc cgctggggcc aagcggatga tatcgggggg actgcagtct 1926301 ttttggcatc acgtgcttca gattatgtaa atggacatat tttagcagtt gatggcggct 1926361 ggctatcccg ctgacaaata aaaaagctga cgaacgatcg tcagcttttt tccattacat 1926421 catgtgcggt tcaacaggca agaccttttt gacctcatca atgatgcgtt cattttctcc 1926481 gccagcgtaa atgtgaatcg agccgctgtc ttgattcgag cgaatcaggc gcccgatgcc 1926541 ctgccgtaca cgtaacaaca tatatggcag atcaacttct tcgaacggat cttttttcgc 1926601 tccgttgcgc ttcgctgtaa atacaggatc gtgtggcggg aacggtaatg accaaatggt 1926661 aacattcttc aatgcgtcac cgggaatgtc gagtccttcc cataagtgaa ctgaacaaag 1926721 tactgtttct tcttcctctt ggaatttctc tactaagctg ctgatttcct catcaccttc 1926781 gaagaaaatt ggatacggca gctcccatgc cgccgacagc tctttaaact cgtttaattc 1926841 ttcaaaagaa gggaaaagca ccagcgttct tcctttgtat cgtttgattg tttcaatcgt 1926901 ttcagccgtt ttttgttcag cgtccatatc tgtttttgcg tatagattaa tactcatttg 1926961 ctcgtcataa tcataagggg aatcaacagt taatgacaaa taatcatgaa tcccaagact 1927021 gtcggcaata taatcaaacg aaccgccttc tgacagcgta gcagaagaaa agatataagg 1927081 aattttctta gaaaacactt tttcgccaag tacttctgct accgttctcg gcatcacgac 1927141 aaaggttgat tctgcttcct ttttctccag ccagctgatc gcatcctttt gatatagaga 1927201 taatgaatac gccatttgtt caacatattc ttccactact gacagttcgt attgatcaat 1927261 cgtatacatt tcagactcaa atacaagtgc ctcaccgatt ttatcaagta aacggcaaag 1927321 ctcgtccgcc gcctttttga cacgatggtc attttttatt tctaaacggt gtgaaccggc 1927381 tacttccttt gattcttcag aaagaacata gaaaaattcg tcgtttgcga gaagcgcatc 1927441 ttcaatcaat tctgcaaact cttctctgat gtcattttgc agcaatcgtt ctaaaaacaa 1927501 ttcaagagta gactgcttca ctctataggt tagcgctttt tgcgcagcaa actctaacaa 1927561 gtgcccctca tcaaatacaa ctgcactatg atcaggcaag agcggcagct ggccctctcg 1927621 tttgcgtgat tcttccgtcc acacatgctc catataaaaa tcatgggaac aaatgattaa 1927681 gtccgttgac ttgcggtagt aatctctgga aagtgtcaga ccgcatctgt gtctcatatc 1927741 acaagtcaga cagtcctgaa acgagtcgta gcttacgtca gaccactctt cattcgatag 1927801 atttgcgtac tgcttacggt cgccatacgg ataaaagcgc tgcatcgcct gggactcgtg 1927861 gacaaatgac ggtaacgact cataaagatc cagccattta tcatcatcag aacgctgcat 1927921 tgttttttca agcttcttca agcataaata ttgctcatgt gattttgaca gccttgtatc 1927981 aattttcaga tcaagatgct cagccagctt agaaatatcg ccctcttttt tcaccagctg 1928041 ttcaattaat gtttcatccg cacaagcgat gatggcaggt ttgccgacat accttgcata 1928101 gctgattgca aaaagaagat ataccagcgt tttccccgtt cccactccag cttcggcgaa 1928161 catgactttt ttctctttaa acgcccgctc cagctgaaaa gccataaata cttgctcgtc 1928221 ccgaagatca aacccttttt cgggaaggat atcgtaaaac acgtcaccaa tccaattgtt 1928281 caattcttca taaaaattct ttgttttcgt taaagaaaaa ggcaaacgtg atgttgtcac 1928341 ctagttccaa cccccaacta ttcgacattc agaccaccaa taatatcatt ttccgctgat 1928401 gaatacaata aaaaacttgg caatgccaag ttttttgcag tttacttacg attgatcaca 1928461 tgcgacgata aaaaaggatg gtctgttgaa taaatatgtt ctaccgcttt ttctaaatca 1928521 gtttgcgcat gcgaaatcac agacggagac gaatcagtcc cgagctcctt cagctcgttt 1928581 gctgttgcgt caagcgccct ttgaataaga ttaaaatgtt cgctgttcag catgagatca 1928641 cctctgatgg aaataatcat cattgtatgc gaacttttca ttttatatac atgctttacc 1928701 gcatgttatc accgaaacat gcacaaacta cacttgatat tccgtctccg gattatccgt 1928761 cttatcaaca atattctatc agggagtgat gttgacatga gttatagaaa ccgattagat 1928821 cagcattctg aactgtttca tcacaattgg acgcggccta aacgttcaaa gtctcaagta 1928881 aacggtcaca ctgaaatgtc ccaaaccaac attatattga gaagcaacgc gaaagctcac 1928941 cgttggtaac gatagaatag ggctgaaaga tgaaagaaga cgcatgcaga gcgtcttctt 1929001 tttatgcgtt ttctgttttc ttgcgctgcg gtcttacttt tgaccagtat tgataataat 1929061 ccgttttaat aaacccgtta aagagttttc gtttcttcgt tgcttttctg ccatatgctt 1929121 cctcaaagtt ttcatttgat gtcagcatat acacagacca agtatcaagc ggctcgaacg 1929181 cctgccccat ttctttgtac atctgctcaa cggctttttt ctcgccgaga cgctctccat 1929241 atggcgggtt gccgacaatt acgccaaatt ccagatttgt ggtaaagtct ttgacctgca 1929301 tctgtttgaa ctggattaga tctcccaatc ctgcttcctc tgcattttct tttgcgattt 1929361 gaaccatgcg gtggtctatg tcgctagcga aaattgtaag cggctgatca taatttgcct 1929421 tttcttcgac ttcaagccgc gctttgttcc acagatcttt accgatccat tcccaatcct 1929481 ctgatacaaa atcgcggttg aatcccgggg cgatgttttg gccgattagc gccgcttcta 1929541 tcgcgattgt tccggagccg cagaaaggat caacaaacgg gcggtcaggc gtccaattgg 1929601 ttaattgcac caaagcggca gcaagtgttt ctttaatcgg cgcaccgccc tgatcgacac 1929661 ggtatcctcg tttgtgaagg cccgtccctg atgagtccag tgtaatcaaa gcctgatctt 1929721 tcaataaaga tatttccact ttatactcag cacctgtttc ttcaatccaa tcattggctt 1929781 tgccggactg cagcttgagc ttttcgacaa ttgctttttt gacgatccgc tgacagtcag 1929841 gaacgcttgc aagtgttgat tttaccgatt ttccgatgac agggaatttc ccgttttcag 1929901 gtataaatga gcgccagtta atcgctttcg ttttttcaaa cagttcatca aatgttttcg 1929961 ctttaaaaga agcaacctga acctttatgc ggtcggctgt tctaagccaa aggttcgcac 1930021 ggcagatggc aagtgcatca ccttcaaaaa taactttccc gttatcaacc ttgcattcgt 1930081 atcctaaatc tcgtacttcc tttgcgacaa cagcttcaat gcccatcggc gccgttgcaa 1930141 ttagtgtata cttcttcatc gtatcaccct gtcttttaaa acttttctct tttcaagata 1930201 aaagctctcc ttatacggga gagcttgttt tcatcatttt aaatgtaagt ggtctaacgt 1930261 tctgtaagcc atgttttgtt ccatcgtact gcaaacggct catcacctcg tactcaggcg 1930321 gcaatcatct atctacagaa agcattctgt ccttctctcc gttgaattcc gttaagaagg 1930381 ttcccctacc aaaatttggg tttctcgctc gaggggttta ccgcgttcca ctctcaccat 1930441 ttctagtgag acttcgtcac tgtggcactt tcaaggatac tcagccatat ccgaagacgt 1930501 aggctttttt cctgccgtca gcctctaaag actgccctag cttatgactt cgctaggcac 1930561 gaacactacg ggcatctcag caccgtgcga gcatggactt tcctctacag attcaagatc 1930621 tgcagcgatt acccgaacgt taagaacatg aattattata taacaactga ttacaattta 1930681 caagcgccat ttttttcaag cgtgatcaat cataaagctt gctgccaaaa acgtgttttt 1930741 ctaagttaga cagccgtttt aaaatatcaa agtttgttgt gttagattgc acaggctgtt 1930801 ttttgctggc ttcttcaagc tgttttttca gctgcagatt ttcctgctgc agttcttcaa 1930861 tttcttgatg gaaggtttca taatccttaa taatcatatc taaaaatttg tcaacgtctt 1930921 cttgcttgta gcctctaacg cctgttttaa attctttttc caaaatttct ttcgcagaaa 1930981 gctttacttt atcagcaagc atctttttca cctcgtatcg tgaatcatca catatatttt 1931041 ttcagaaatc tgtacggttg tcaaatttct ctctcattgt tagtagctgt cttcctccac 1931101 tgtcactctc aagtcatcca ttgtaataaa gtagatggga tagccatcct gttcgcgcct 1931161 tttttccgct gtcccaagca tatacttagg ggagccttcc ttttccgggt catataaaag 1931221 cagaagcccg tcggacttat caatgaagaa ctgatttttt tgtttgaatt gaagcgggct 1931281 ttcataagga cggtgagtca ggcttgcttc atagtctgcc tgagccagaa ctgcttcata 1931341 ctgttcttta ttcggttctt tccagttctt ttcctgctcg taaaatggtg tgatgacagc 1931401 tacctttaag tcagggtatt cctcctgcaa atcatatgca gcttctgccg cccacagctc 1931461 aactccaagc tggcccgaaa ttaaaatcca ttctaatcct tcatccaaaa aagcaatcag 1931521 ccggttttta atggcttttt ttatgtaata cagcgccttg tcatcctgct taaatatccc 1931581 cagttcaaac ggtttatagc ccgttattgc caatactttc atcatttcac ctgctttaaa 1931641 aaatggggct cccgtgggcc ccatttgttg tgctgcattg tttacaccat caagctgcac 1931701 gttttccata ctagtagtcg cagcaaggtt ttcctgcttg aaaatgctga tgcgtagccg 1931761 ggtcaacatt tgagaaagtg tgtggaaagt agtgaacgtg ctgaaaatgc tggtggttta 1931821 cgtttgttgt atgctgtggg tgaatgtgcg gcacgatagt cttcgaaaac gtatggtgtt 1931881 cacagcaatg agtaggatgg acaattggcg ccatcatatg cggtctgcag tgatgcatga 1931941 taaaatcccc tttccataaa ctttattaca atactaagtt atgaaaaata aggggtacat 1932001 gttctgatgc aaagacctat tttaaaagtg tgcaattaag ctgtctttaa agtttgaaaa 1932061 cacaaaagca atcaaaaata ccacaacaaa gaacaagtaa aaaacaccct tatacatacc 1932121 aactctccct ttaaaaataa ctaacgtcat tttacaggat tcgccgctat tctacaacaa 1932181 aatcaatgtg aattcagcaa aaaaaattca tggcgaaaca agtcgtcttt tgcgctttcc 1932241 cggggaatat ttaagaggaa tatttcctct ttagccgggc aattctcaca tgcagttttt 1932301 cagtttcttt ctctgataag catgccgcat cgctaagcga ttgctctgct acttgcaatg 1932361 cttttccgaa ttcttttttc ttatgctcaa aatatttcgc gagctctatt acagcagcgt 1932421 atctgcactt ctggttttgc gagcgggaca gcttttccca aagcggcact gcttcttcca 1932481 agcggttttg ttttttgtac aggagcgata aatccagccg tgcactgtcc tggtcctcaa 1932541 acgatttttc tataagcctt tccaactgct tgatcgcttg gtccgtttct ttatgagcca 1932601 taaaccattt cgccatagca taggcttcac tgtgttcttt tggcgcatgt gattctgaaa 1932661 ggattttttt agacatatgg atgtacaatg aaatgagtga taacacatcc atttcattat 1932721 gatgcaggac accttttaaa agatccggct cttgcgcctt gataaaatga aagtaaagca 1932781 ttggcgccaa gtagcccggt gtgtcttcta gcctgcggat gccgagctcc tctttttcaa 1932841 ccgtgccaag agatacacgg tccattttgt gtttccacag gcgtctagct ccatgcaaaa 1932901 gatcaaagtg gccaaactcc ggaagcttcg gaagtctgtc acggatcaag gtgtgccttg 1932961 ttttcacctg cggccaatca aaggctttgc cgttgtaggt cacaagtgat gtaatgtcaa 1933021 cctcgcttaa aaagctttgg tacaaggcga cttcgttccc cggtttgggc aaaagatgct 1933081 gtttgactgt cactcggtct tcatatactc tcgcatgccc aagcaaaaaa atggtattcc 1933141 cagctccacc cccaagaccg gttgtttctg tatcaaagaa aaagaggttg tttttgttat 1933201 acccttttgc tgacaatgta tgcgacaggc cgctttgatt ccacagtgtg atcacttcct 1933261 caagctcaga aaagctgtat aacccatggc ggtgagaaag cggatattct acttctctga 1933321 tgaggcaata ttcatcttcg aagatgaaag gcttcatgcc aaaagcctcc cactcttcta 1933381 aaaacgggat gtcatcaaag tggttttctt gtttgcctgc ttctattttt tgttctcctt 1933441 cgtcgagcgc catgtgcttt ttcatccgtt ggagtttccc ttttaatgac atatccggcc 1933501 tccctcctta cgacatttga tccaacagct gcaaaattct ttcctttgct tttatccctt 1933561 ctatttccgt acctatacaa gacggacagc cgtcatgaca aggacaatgt gtaatcagtt 1933621 gtttcgccgc ttcattaatg tctgaaaaac gtttaaagac ttcctccgcc aaaccgatac 1933681 cgcccggata atgatcatat aaaaatatgg ttggcaatcc ggtatgggct gctttaattt 1933741 gagaaacaac atgaacatca tttcgatcac acatgatata cacagggaca atatgctgca 1933801 gcacattcga gatgccaaga agcagctgtt ccagtgtctt ttccccgatg tcttcatccg 1933861 ctgttttgat ttcgagccaa gctgcacttg tatgcagttc ttcttccggc aaatgaatag 1933921 gtccagaccc aatattttca aaagtggtca tttttatttt tttaaaaatg gtcggcaggg 1933981 cattgacagt gacgtctccg tagtgcaatg acgtacggct tttttctttc gttttatcga 1934041 tttctaatac cttcagctga actgccaggt ttgcatccgt ataatattcg acatcgactt 1934101 ttctgacata cgccttttta tggtcccaat cgagcttctc aacttgatac tgaacgcctt 1934161 catgcaaata aatcgcttca tcatgcaaaa gcgtcatcgc actaaaacgg tccatttcac 1934221 cgataatcct tacatttgca atatccgact gatcaactat aacgacattt tcctgggagg 1934281 cggaacgcaa actgatgttt gacgcaggga acgactcact tgcccaatgg taccgttcgc 1934341 cgttgcggtg aagaacagcc tcttcctgaa gatactcaag aatatcactg acttccatgg 1934401 ctccaaattc ttcatcagct ctaaaaggaa gctcataagc cgcacacttt aagtggtcta 1934461 ctaaaataat caaattctcc ggattgattc ttgcagattc cggcgaacga ttaaagaaat 1934521 attcaggatg ccgcacaata tattggtcaa tcggtgttga attggctacc atgataatca 1934581 aagattcacc gtgtcttctg ccggctcgtc ccgcctgctg ccaagcactt gcaacacttc 1934641 cgggataccc cgtcattaca cacacttgca gctggccgat atcaacacca agctctaagg 1934701 cattcgtact gaccactcct aaaatgtcgc cttctctcag tcctctttcg atttctcttc 1934761 gctctttcgg cagatagcct ccccgatagc ctctgattga ttttgttcca atctcttttt 1934821 tcacaagctc ctgaatatgg cttaaaataa tttccacccg aactctgctt ctggcaaaaa 1934881 caatggtctg cactttgttt ttaaggaact ctttcgccag ttcattcact tctgcggttg 1934941 cgctccttct aatattcagc ggtttgttca caattggcgg attgtaaaac acaaaatgct 1935001 tgcgtccgct cggtgcgccg ttgtcatcga ccagccgcat cggtttgcct gtcagctgct 1935061 ctcccaattc ctttgggttg gcaatcgttg cggaagtaca aataaaaact ggatcacttc 1935121 cataaaaccg gcagatccgc ttcagccgcc ggatcacatt tgccacatgg ctgccgaaca 1935181 cacctcgata cgtatgaagc tcatcgatga cgatatactt aaggttttca aacaaactga 1935241 cccatttcgt atgatgcggt agaatggcag aatgcagcat atcggggttt gtaatgacaa 1935301 tatgacctgc ttttctcacc ttttgtctga ttgccggaga cgtatccccg tcatatgtaa 1935361 agcttttaat atcaatgccc atttcatcaa taatttcatt tagctcgctc ttttggtctt 1935421 gtgccagcgc tttagtcgga aataaatata acgcccggtt tgtttcatct tgggcgatgg 1935481 actgcaggac tgggaggttg tagcataacg tttttcctga tgctgttggc gttacggtaa 1935541 cgatgctctc tcctttttgc acatattgaa aagcggaata ttggtgagta tatagttcat 1935601 caatgcccct tttcgaaagg gccgctttga ttctctcgtc tatactttcg ggcataggcc 1935661 ttgtttttgc ttcccgaggc tcaatttcat gccaattcac aacgttttca tttcctttta 1935721 aatcagaaat gagttcagtc agtgatttct ttttcattct ttacacctct ttgtcaagta 1935781 cagtttaccg aatatttgtt tgcatggcta ggtgcaaatt ttatacagtt gaataaaaaa 1935841 agcaaggcat acgccctgct tatttcgctt ttattgtaaa gagctttgat tcgcctttac 1935901 gagcagcctt ttcgcctgcc gataccattg atcctacagc ctcaccattc attataacga 1935961 ttgggatgac tgtgctgctc gctttttctt ttattaattc caaatcacat gtaatcagcg 1936021 ggtcaccgac cttcacttta tccccttctt taatgtgggc agtaaatcct tctccgttca 1936081 tattgactgt ctccagcccg acatgaatta acagctcaat tcccgagcga gtccgaatgc 1936141 caacggcgtg tttggtgtgg aaaatctgaa tgacttcacc ttcagcggga gaaacgattt 1936201 caccgctaga aggttccacc gctattcctt ctcccatcat tttctgtgaa aaaacagggt 1936261 ccggtacatc tgacaggtcc attactgtac cgtctgccgg agaataaata acctcttctg 1936321 tcaccttttc ctgaattttg cccattccga ataatttttt cagcaatgta ttttctccct 1936381 tctcattcac ttcaaccgtt atcccttcat tcaccactat ttaaccacac tttcaatttt 1936441 gcttcaattt ataacaacat ctggcataga cgcataatct ggttaaaaaa ggcggtggcg 1936501 atattggaat tccatgatga caaaaagaac gaactgcaaa agaaagaaga aatcataacg 1936561 gaggcaatcg acactctttt tcaatcctca gcgttcggca accttataaa cggatttcag 1936621 aacctaatca actcgagttt aaaggatgtg cagacgacca tacatgtcag agaaagagat 1936681 actgggctgt atatcgatat taccattccg gcgacgtttc gagatggcga gatcgtcgtt 1936741 gatgttaaat cgaggtatct ccatgtaaca ctccaagaaa aacagaaaca ccaaaatgag 1936801 gctaccttta caagcatgac aagaacggtt cagctgcctt atgaagttcg ccaagaagat 1936861 atggaaacgt cttggaacga gcagacaatg acacttttct ttccaaaaaa taagcatgaa 1936921 tgaacgattc attcatgctt ctatcattta aaaaagctgg taaatccctt tattaaagat 1936981 ccgacctgat tcattgcact cattacttga cctgtcgtat ccatcatttt attaaaatca 1937041 aattgcccat tggctttttt gaactgcgac ataatgcttt gaaattgtga aggctgctgt 1937101 tgattaggcc ttgggatagg ataagggtta gaaaatacag gcggctgcat aggcataggc 1937161 tggatcggag cataaggctg ataataatcc tgctgtccat aatgctgctg aggcagttgt 1937221 tgctctaaat aaccgggtgc agcctgctga taatatcctt gcatatgctg aggataataa 1937281 tagcccattt gccgaggata gcttcgagag ctcccgttca ttgcgattcc cccctaaaca 1937341 caacatattt ctcttctata tatgtatgaa tgacttctat tgtttgtgtc acaagtgatg 1937401 attagcattt gtcaaattgt gtcgaaagtt taaatttttt aaaaacagaa aaaagtcgaa 1937461 tcattatggt accatatttt caatacagat gagaggggat gcaccataat gaacgtatca 1937521 tacttaagca aacgttttgc agaaatgaag aaatatgaaa cagactgtat gaataaactg 1937581 atggactttg ccaagttcct ctatattcaa ggacatctca gcataactga gtttcgtaac 1937641 agtatgaagg ttctcgaagc aaatggagca gaaagcccgg catatgagat gaattaacgt 1937701 ccggccccct ataaaaacga aaagaagaca gccttttacc ggctgtcttc tcttgcaatt 1937761 tcatccttta ctgcgtgcaa tgtataaagg actgactcag tgatgtcctt gaatcgtttt 1937821 ttatgaatat gatgaacata agattgaagg accaattcca ggaaattatc ctttacggcc 1937881 tcaatttgct ctttatgcac atattttggc cggcggactt ttatcaattc aagagcaccc 1937941 tctgcccagc gagcagccag ttcatcattc tcttcaactg caggctttat cgtctcaaaa 1938001 aaatcataag aatgattact gttttttcct tcctgatacc gatcagcgcc tttttcagca 1938061 acttcaatca tttgctcggt catttccagc aaagtttgtg atagcaatat ctttcacctc 1938121 aatgcctatc gtaccaaatt tcactcacaa attcagccga tgcggtatac cttctcaaac 1938181 gcatacctgt gttcaggcga ttgatacagc tcatttatac aaatatgaag atctatgatt 1938241 tcttcttcga gcacacttag gcgatcgttc tccgtttccc gcatctcagc ctctaatgca 1938301 tttacagaat gattcaggct ttgctcagct cgcgttaatt catcttctat atcagaaagc 1938361 atacggagaa tatctgtctt gcatacataa ccggacattc gtgtacctcc ctttccttgt 1938421 ctctcccggt taacattctt tgctctcaag gctctttcct tcctcatgac aaaactagaa 1938481 gcaaatcgcc aaacaaacag gtattccacg aaaagctgaa gttttcgaca aaaacacccg 1938541 caaaaattgt atgatcctcc tcattaatgc aaacgatact tgtgaggagg tgccgtatga 1938601 aaacaagacc gaaaaaagcc ggccagcaaa aaaagactga atcaaaggca atcgattctt 1938661 tagataaaaa attaggcggc ccgaaccgcc cttctacgta agaagcaagg aatttccttg 1938721 cttctttatt ttttcagcca ctgctccacc gcaaaaagcg catgaagctg gcgcttttta 1938781 tgtaaatacc agtctgtcaa ttcaatctgc ttcggcaatt cctcgcgcct aaagaacgtt 1938841 ttctttatct ttccatgaaa ccaatctgtt ttcgttccgt ctaatgagtg gattaactca 1938901 gggtagcatg tccttagcat aggagatgtt ctttttgtaa tcccgatcat cttttccata 1938961 tcaaaacggg aacctgtgtg cggcactgtg tgcaaaaagt gataaaaaga ggagaacaat 1939021 tctggcttga acagcaattg agacagctgc tttcccagcc ttatcctttc ctccgccttt 1939081 gaaaagcgtt tcactgaaat gccgtaaaaa aacccatttg aggaaggaaa aataacggtg 1939141 ttaaaatgaa accagtcact taaataaaaa ggaatcgtgt caaaaacatt ctttttaaac 1939201 gaaggatttt gtataatagg tgtttggata gtgttttgtt catttataat gagggcatac 1939261 attagccgct ccgtatttcg ctcatgccaa aaacgggtcc attcttccga cataaattgt 1939321 gagacgccaa acacatgcag cagatgaaac agcggtttcc caactctttt tgaccagtgg 1939381 tataaaagaa gctgcggata ggcatccgaa aaaataagcc agttcgctct ttcataggct 1939441 aaaaagaacc atttttgctg tctctcacgg agtccaagct gaaacagact gccttttaag 1939501 tcagtcattg accagccggc attacgagaa acgaaagaag ccaaaagcga ccatttgatt 1939561 tccggatgac ggtcgtaaaa tgctttataa gcatttgttc ttgaaatgtt atccgcgttt 1939621 ttcatttttg tctgccgctc aatccggctc agaagctttc tgatggcctg ttgttcttgc 1939681 acgttcattc acttccgtca tgattagttt aataaggagg atgagaaagt gattcggtat 1939741 cctaatggaa aaacatttca gccgaaacat tcggtttcat cccaaaacag tcagaaaagg 1939801 gccccgtctt acagtaatcg cggaatgacc ctcgaagatg acttaaacga aacgaataag 1939861 tattatctga caaaccaaat tgccgttata cacaaaaagc cgacacctgt tcaaattgta 1939921 aatgtccatt atccaaaaag aagtgccgca gtgattaaag aagcttactt taaacaatca 1939981 tcgacaacag actacaatgg gatttacaaa gggcggtata ttgattttga ggcgaaagaa 1940041 acgaaaaaca agacctcttt ccccctgcag aattttcatg accatcaaat cgagcatatg 1940101 aagcaggtaa aggctcaaga cggtatttgt tttgttatta tatccgcttt cgaccaggtt 1940161 tattttttgg aagccgataa gctgttttat ttctgggaca gaaaagaaaa aaacggcaga 1940221 aaatcaattc gaaaagatga gttggaagaa acagcttatc cgatttctct tggatacgca 1940281 cccagaattg attatattag tattattgaa cagctttatt tttcgccatc atctggtgcg 1940341 aaaggttgat taacgaaagg ttgagatgtt atgtcagatc aatttaacag ccgtgaagct 1940401 cgacgaaaag cgaacagcaa atcgagtcct tcaccgaaaa aaggcaagaa acgaaaaaag 1940461 ggcggattgt ttaaaaagac ccttttcact ttactcattc tgtttgtttt aggcgtagtc 1940521 ggcggtgctg ttacatttgc cgtcatggtt tctgatgcgc cgtcccttga tgaaagcaaa 1940581 ttgaagacgc cttattcatc aacgatttat gataaaaatg gaaaagagat cgccgaagtc 1940641 ggcgccgaaa aacggaccta cgtctcgata gatgaaattc ccgatgttgt aaaagaagcc 1940701 tttatcgcga cagaagacgc tcgtttttat gagcaccacg ggattgaccc tgtccgtatc 1940761 ggcggtgcat tagttgccaa ctttaaagac ggcttcgggg ctgaaggcgg aagtacgatc 1940821 acccagcagg tcgtcaaaaa ctcccttctt tcacatcaga agacgttgaa acggaaggtg 1940881 caggaagtat ggctttcgat tcagctggag cgcaattact ctaaagatga aattttagaa 1940941 atgtatttaa accggattta tttttctcct agagcatacg gaatcggaaa agcggcggaa 1941001 gaatttttcg gcgttactga tttaagcaaa ttgactgtcg aacaggctgc gacgcttgca 1941061 ggaatgccgc agagcccaac agcgtacaac ccggtcaaaa acccggataa agcggaaaaa 1941121 cgacggaaca tcgtactcag tctgatgaaa aagcaaggat ttatttctga ttctcaatat 1941181 aacaaagcga aaaaagtggc agtgaaagac gaaggcgtcg tgtcacagaa ggaatatgaa 1941241 aaagcaagta caaacaaata cagcgcattt gttgaagagg ttatgaagga aattgatgaa 1941301 aaatctgatg tcgatccatc tgctgacgga ttaaagatct atacgacatt agatacaaaa 1941361 gcacaagata aactagatga attaatggac ggagacaccg tcggatttac tgaaggcatg 1941421 cagggcggtg tgacgcttct cgataccaaa aacggagaag tccgagcgat tggtgcggga 1941481 cgcaatcagc ctgtcggagg ctttaactat gctactcaaa ctaaggcaca gcctggttcg 1941541 accataaaac cgattttgga ctacggacca gttattgaaa ataagaaatg gtccacatac 1941601 gaacaaattg atgactcagc ttatacgtat tctaacggaa aaccgattcg tgattgggac 1941661 cgcaaatatc tagggcctat ctcaatgcgt tacgctctgg cccaatcaag aaatatacct 1941721 gctttaaaag cattccaggc agtcggtaaa gatactgctg tagactttgc aaatggactc 1941781 gggcttggtt taacaaaaga taatgtaaca gaggcctatt ctattggcgg tttcggtggg 1941841 aacgatggtg tttctcctct gacaatggca ggtgcataca gcgcgtttgg aaataacgga 1941901 acgtataatg aaccgcattt tgtaaaatct atcgaattta acgatggcac gaagcttgac 1941961 ttaacaccaa aatcaaaatc agccatgagt gattatactg cgtttatgat tacagatatg 1942021 ctgaaaacag ctgtgaagac aggtactgga cagcttgcac aagtacctgg tgtagaagtt 1942081 gcaggaaaaa caggaacgac taactttgat gataatgaag tcaaaaggta caatatcgct 1942141 agcggtggcg cccgagattc ttggttcgtt ggctacacac cgcaatatac agctgccgtc 1942201 tggacgggaa tgggagaaaa cgaggctgga aagaaatcac tttcagctga agagcaaaaa 1942261 gttgcaaagc gcatcttcgc ccagctcatc gccgatgtcg atgacggaag cggatcattt 1942321 gagaagcctg acagcgtagt ggaagccacc gtagaaaaag gttctaatcc ggcaaaactg 1942381 gcagggccaa atacgccaag cgataagaag ctcacagagt actttgttaa aggcacagct 1942441 ccttctactg tttctaaaac atatgagaaa gaagaaaaag aggaaacagc taaactgtct 1942501 ggtttaaacg tgaaatacga taaagacaat caatctttaa cgttaagctg gaattacgac 1942561 ggagatgcga cctttgctgt taagcaatct gttgacggcg gcagctactc ggaaattcaa 1942621 aacagctctg caaaagaggc agttatttcg ggtgtgcagc caggatctgt atacaaattc 1942681 gaagtaacag ccgtcagtga tgatggcaaa agtacagctt ccacatctta tgaggtgcca 1942741 aaagctgaag acgatgaaga taaaaaagac cagcaacaaa cggatgatga aaaacaagat 1942801 gatgagaaga ctcaggatga tacacaaact gatgattctc aaaaagatga cggtcagacg 1942861 gatcaagatc agacagatga ttcaacaaac gatcaagaca aaaaacaaga caatacgaac 1942921 accaatccgt ccgacaacaa taaccaagac caatcaaacg ataatgataa cgacaacagt 1942981 aacaaccagg atacgtcgga tggtgattcg aactctggta agaatgattc aacaggttct 1943041 gacacgaata aaaataaaac agacacatct aataaaacac aaacaaactc atcatccatt 1943101 gaaaaaacaa attaaacaaa aaagccgtca cctttggggt gatggctttt ttggtacaca 1943161 ataaaaaacc tcccgtttta acaggaggtt ttatcgattc atcgcatgat atttataaaa 1943221 atgctttttc atttcggtaa tcagctcatc aagctgaata aagcaatggt attgggtcgg 1943281 cttaagaaga ataaattcca ctcgttcagc ccaattaatc ggctttgcgg gatatgattt 1943341 ctccctcagt tcttgccaat cgagcgattt caccggctca cctgctgtcc aatgtaacga 1943401 agccagcaaa cacacaatgc cctttaacat ttcgttttgg tcacatctcg attttcgtgt 1943461 ttgaaagact gggagaagtg atgctttgat gtcatcccac acttcaaata aaagcggaac 1943521 gtatttcccg ctgtcctccc atggcaaatc gccttgtaat tccgtgcaga aatcaaaata 1943581 cacgggattg gtctgcaagg ttttcttcat atccgaggaa ctcttctggc caagactgcg 1943641 caagtattgc tcataggaag ccaacacttc ttttgcttgc gtcatcgttt caccagtcct 1943701 tttttatccc tcttctgccc ttctctgcac aaagaaagca gcggacactc cgcacagcgc 1943761 ggagattggg ctttacagtg atatctgccg aagaaaataa gccggtgatg cgtaacggac 1943821 caatcttctt tgggaacctt gcgcatcagc gtcttttcaa cttccagaac cgagtccttc 1943881 caccggcaaa tgcccaatcg tttgctgact ctctccacat gggtatctac ggctatggcc 1943941 ggcacgccaa acgcaacgga taccactacg tttgcggtct ttctcccgac ccctggcagt 1944001 ttgacaagct catcgcggtc tctcggcact tctccgccgt aatcttcaat aatcatttta 1944061 ctcagctttt gaatattttt cgctttatta cgatataaac cgattgattt aatatcctgc 1944121 tgaagctctt ccagcggaac agccaaatag tcttccggcc gtttatattt ttggaataat 1944181 gttttggtca ctctgtttac aagtgcatct gtacattgcg cagataaagc aacagccacc 1944241 actaattcaa aaggattgga atgaaccagt tcacactccg catgaggaaa catgtcacct 1944301 atcttgtcta aacagaattc aatttgtttt agatttaaca cgattgtcac cttttcactt 1944361 tattgttcaa gccaattgta aaaaggaacc tgccttttat actctttttg cggttcattc 1944421 tgctttgctt gtacacgccg gaatttttgg ctgtgtattt ttgcctgctc cacagtttta 1944481 agcccatttt tcttccattc aaacaaaatc cggtcaatgt agcggaaact gagttttcct 1944541 gatagtacag cctcttttaa cgcgtgtttg atcagttgtg cgtcatgctg atcctggtcc 1944601 tgccagatcg ccagcgtttc acactccaaa ggcgataacg gtcttgcgaa ctcttcctca 1944661 aaaatggtat aaaggctttt ttgttcccct tctgcttttc tttcctgtgt ttgattctgt 1944721 gcaagctgaa tatactcgta cagcttgccc cataaaggct gaagagaata tttctcaaat 1944781 ttgatgccgt tttgatcctc gcattcttca ataaacagaa agcctttttg aataaacatc 1944841 cgcaatctgt ttgtacattc ttcaacagaa attgacatac cttcctgcag ctgattcggt 1944901 gtaggaaaat atgatccttt ttctaaatgc attttaattt ttaacagcag aataagttct 1944961 gtttcattaa gcccaagctg tttataatgc gtgagcagaa gattggggat ggttgatgtt 1945021 ccctgctcct gcatatcaat aaattgctgt tttttcatcg tcacacctct tactgtaaag 1945081 gattgtgatt gcccctttac tgtaaaaagt ctcccttgca ggagactctt ttttgtttca 1945141 tttgaatgta ttacggatac agacggttta acagtcttgg gaacggaatc gtttcacgaa 1945201 cgtgaggcgc tccgctgatc caagctactg tccgctctaa tccaaggccg aagccggaat 1945261 gaggaactga tccatatttt ctaagttcag cataccattt ataagcgtca gaatccagtc 1945321 catgttcttt aagacgcgat tccaaaagtt ccatatcgtg aatccgttca gacccgccga 1945381 tgatttctcc atagccttcc ggcgcaatca agtcagcgca aagcacaacg tcctcacggt 1945441 cagaagccgg ctgcatatag aacggtttta aggacgtcgg atagcgagtg atgaataccg 1945501 gtttgtcata atgttcagca atcgctgttt catgaggcgc tccgaaatca tctccccact 1945561 cgatatcgtc aaagcctttt tctttcagaa attcaatcgc ttcatcatac gtaattcttg 1945621 ggaacggggc tttgatttgc tcaagttttg acgtgtctct tcccaatgtg tttagttcaa 1945681 ttttgcaatt tttaagaact gattgcacga tgaaagaaac gtaattttcc tgtacttgaa 1945741 ggttttcttc aaattctaca aacgccattt ccggttcgat catccagaat tcgattaagt 1945801 gacgctttgt tttagacttt tccgctctga atgtcggtcc gaaagagaat acttttccta 1945861 aagccattgc cgcagcttcc atgtagagct gtccgctttg agacagatat gcatcttcat 1945921 caaagtactt tgtcgcaaag agttctgttg ttccttcagg tgcgcttcca gtcaaaatcg 1945981 gcggatccac ttttacgaag ccttcgttat taaagaattc gtaagtcgcg cgaatgattt 1946041 cattacggat tttcatgatc gcatgctggc gctttgaacg cagccataaa tgtctgtgat 1946101 ccatcaaaaa ttccgttccg tgttcttttg gtgtaattgg ataatcggtc gcttcgtgaa 1946161 tgacttcaat atctgtcaca gcaagttcat atccaagcgg agaacgctcg tcctctttga 1946221 caatcccttt tatatagagc gacgtttcct gcgtcactga tttagctgtt tggaaaatgc 1946281 tttcttccac ttccgctttt actacgacac cctgaataaa accggtaccg tcccgaagct 1946341 gtaaaaacgc aattttcccg cttgaacgct tattagcgac ccaagctccg atcgttactt 1946401 cctcacctac gtgcttgtac acttggttga ttgttgtttt caacatattt ccctccaaaa 1946461 caagaaagac attcggaagc tcattgcccc gcgaactctt ttatcatcac tttattatac 1946521 ccgctcttaa ctaaccgggt caatgcagat aaaaagcggc ttttctgtca gccgcttttt 1946581 gatctgttag ctatgttttt ctacaaaacg cttgattctt tcaatggctt cttcaagaag 1946641 atctaacgat gttgcataag aaagacggac attctcagga gagccaaatc cggatcctgg 1946701 aacaatcgca actttttcct cctcgagaag cgctttaaca aattcatcta catctttgaa 1946761 accgcaagat tgagctgcct cttttgcatt tgggaacaag taaaaagcac cttccggctt 1946821 cacgcagctg aaccctggga tttctatgag ctttgcatag atcgtattta atctatgttc 1946881 aaatgcttct ctcatttctt ccaatggctc agaaggcccg ttataagcag caatcgctcc 1946941 gtattgtgcg attgatgtcg ggtttgacgt gctgtggctt gcaaggttcg tcatcgcttt 1947001 aataatgtct tcagagcctg ccgcataacc gattctccag cctgtcatgc tgtgggactt 1947061 cgatacgccg tttataatga ccgtttgctc tttcagtctg tctgacagct gtgcaatgga 1947121 aacatgtttc tttccgccgt atgtaagttt ttcataaatt tcatctgaca caatcaagat 1947181 atcatgttca aggcacactt caccgagcgc agatagttct tcttccgtat acatgacacc 1947241 agtcgggttg cttggagagt taataacgat tgcttttgtt ttttccgtaa ttgcattttt 1947301 cagctgctca ggcgaaattt tgaagtgatt ttcctcaagc ccttctacat aaacaggctt 1947361 tccgccagcg agtttcacct gctccgggta gcttacccag taaggcgttg gaataataac 1947421 ttcatcttct tcatccaaaa tcacttggaa aagggtatac agagcatgtt tggcaccagt 1947481 gcagacaata atttgagacg gtttgtattc aatattctgg tcgcgtttaa atttctctgc 1947541 aatgctgttt ttcagttcag ccaaaccacc ggaaggcgtg tatttcgtat ggccctcgtt 1947601 catcgaacgc acagcggcat caataatatg ctgcggtgta ttgaagtcag gctcgcctgc 1947661 tcctaagccg atgacatcat ggcctgcggc tttcagttct ttcgctttcg ctgtgattgc 1947721 cagtgtggtt gatggtgtta atgcggatac tctttttgcc agtttcaact tgaactcccc 1947781 ctaattcgtc ttaaggcgtg atatttttga gaatctttcc agttgtaaag tccacataac 1947841 ttaaactgta ttgcccttct ttgtctaagt acgtcacttc ccaaagcagg acgtttcctt 1947901 ctcttgccag atgaacctct ttttgctttg aaaccagccc ttcatccttt atgattttcg 1947961 ccgctttgtc ttcagagatt ccctctttcg cttcttttga gagaattttt gcttttttat 1948021 cagcaggaac ccagacatat aatgcagtgc cttttttatc cgttcccttt acaacataat 1948081 atttttcttt tccgacaaat gtttcgactt gatcaacatg ggcgagatcg gtttcttttt 1948141 tagcttcagc agctgctgct tcgtgcccct cttccttttg tgccatggct gatttataaa 1948201 tgcttgccga gacaagaagt actgctaaaa aaataatacc aaaaatgacg gtaaatatta 1948261 atgctttttt tctcatcttc tcacctacgt acgataaatg gtaaaaacgg cttggttttt 1948321 gttttcttca tccagcgcaa ggccgaacat cagattgtct cttttcagtg tacgattcaa 1948381 tgtgtccaca attttataca gatcatcaga atgctctaca ttaattgttg aaagaatttc 1948441 gattttactt tccatttttt catcctccag tttgaacaaa tattgttagt catactccat 1948501 ttcaggacac gccatactag tatcacagag cgggaaatcc gcttttaaat aaaacaccat 1948561 cctactccca caccgcaaaa gccgctttat gcggctttta ttctttttcc cctgcaacat 1948621 aagcttcaag ctcgctgtca gtcatttcgg atactgaggt tgtcggcaag gcatcaagaa 1948681 acagccggcc gtaaccagcg gttttaatcc gtctgtccaa tataataatc gttcccttgt 1948741 ctcccgcaga acgcagcaag cgtccgattc cttgcctgaa ggtcagcaca gcttccggta 1948801 atgacactgt ttgaaacgga ttctttcctt ttttgcgggc aagctcacat tttgcagcat 1948861 gaagcgggtg atcaggggac cggaatggga gcctcacgat cattactgtc gtcagctcat 1948921 caccagggaa atcaacgcct tcccaaaaat gatttgttcc gagcaggatc gcctgattgg 1948981 atgttttaaa agtcttcatc agtttgccgg gacttccgcc tgtaatccct tgtgccaaga 1949041 gctgaatgcc ggaagcactc atgttatgct taagctcctg gtgaaccttt ttcagcatat 1949101 catgggatgt aaacagcaca aggattttag gctgtttttc ctttgccatc agttcgatat 1949161 aacgggctgt atcctgtata aattcaggtt gccctgtatc ctgaattgat ttcatttctt 1949221 ttggaatcat cacctgcata cgctcatcgt aagaaaaggg tgactcaatt ctcattgtcc 1949281 gcgggaaaaa gtcactcagt cccagtcgtt caatcataaa ttgaaaagaa ccttcgactg 1949341 taagagttgc agatgtcagc accacactat ttttgcgcgc gaaaaactga tcagccagaa 1949401 gttcaccagg ttcaagaggc tgtgcgtaaa tggccactgc atttttcgca ccctttgcat 1949461 ctatttcaat ccaaaccgct tcatcgtcat cagagccaaa gaagagcttc tgcaacgtct 1949521 gacagtaatg ctgcaagcct ttcatgcttc tttggtattc atcggctaaa aagacggttt 1949581 tgctcttcat gcccttcaaa tgtttttcca taagggatga ctgcgcctca aaaagctgct 1949641 gcaaatgtgt cagcatggaa caaagcctct ccgcaccatc tgttaagatc gaccagcttt 1949701 tatcctggct ttctttgttc accttaaaca ctagacggtt taagtcttct ttaggttttc 1949761 ttcgtttgac aaaagaatgt acagagctaa agaaagcatc actttctgct tgaacgtgct 1949821 gaagccactc ttccaattcg aaaaatgaat caaccggcag gctgtttcgc tggaatagct 1949881 gtctcatctt ttttagaagt ccctgctcct tcagagtgcc gattctgctc aatttcgtat 1949941 gcaattctat gtacgtggct cttttcccta aatgttcgct tgccgcacgt tcaaaatggt 1950001 gtgcttcatc aataataaat gtgccgcttt cgggaagcct ttttttatgg ctgccttcat 1950061 cggtcagcaa aagagaatga ttggtgatca ccaaatcgga acgcatagca atctgtttgg 1950121 cccgctcgta aaaaccgatc acatgctcac tgcgacttct tttataggag tcatcgtcat 1950181 aagccaatct gtcccacagc aattttccgc ctgaaggcaa attcagttcc gctacatctc 1950241 ctgtatttgt ctctgtcagc caaacaagaa gctgtgcctt tgtcagtacg gcatcataat 1950301 tatcatcttc ttcatgaagc acctgctcaa atttatacag gcataaataa tgcgattgcc 1950361 cttttaaaat cgccgctgtt accggaaatg gaaacagatc ttggacaatc ggcaaatcct 1950421 ttgtgagaat ctgctgctgt aaaagcgtcg aatacgtgct gattatgacc ggcttttttg 1950481 atttcttggc aaaaagcgca gccggaataa gatagccaat cgtttttccg atgcctggag 1950541 gagcttcaat cagcgcatgc tcacgattgg caaacgcatc agccacctct ctcatcatca 1950601 tcatttggcc gtctcttttt tcatacccag gcattaactc tgacagcgct ttttcatttc 1950661 ccgcttccca gctttcgatc tcaaatgaga agttctcgtc ctcatttata cgaacatcga 1950721 tagcttcagg ttctctgaca gaaaacgaag aaaagcgcgt atagcccggt atctcggtat 1950781 gtctgttttc attaatgaac atatccaaca aatgcgtcag atcactgatg aaatgctgcg 1950841 aaagccttct taactgcttt aatgtcggat aaggaagctg ccgcagcttt tcaaggattt 1950901 ccaaaaaaat aagccctgtc acttcagcat cgctgtcagc ccggtgcggc tgatcatgcc 1950961 gcagctgaag ctcctcgctt aattccgtca gcttataccc ttcaaatccc ggaaaaacaa 1951021 tgcgtgagag ctcgacagta tcaagcactt cacaatctgg gagctgaaag cccgccttat 1951081 gtagctcata cttgacaaat ccaaggtcaa aatggatatt gtgggcgaca aaataagcgc 1951141 cgtcaagcaa ttggaatact tcttcagcaa ctgcttcaaa tggctgttca ttctcgacca 1951201 tttgattaga gattccagta agctgctcaa taaaagcagg gattgattta tttggattaa 1951261 tgtattttga aaaccgctca gtaatttgtc cattttcgat tacaaccgct gcgatttgta 1951321 tgattttatc gcctttcttc ggcgaattcc ctgttgtctc tacatctata acaacgaacc 1951381 gttgcttatt cattaaaatg gacacctcaa ttcttgcata cgacaaaagt gtaacacgtt 1951441 ttgtacggaa atggagcggc aaaaccgttt tactctcaaa atcttaaaag aaaacccccg 1951501 ataaaggggg cttttcttct acaaaattgt acgggctggt tcgttcccca gcatttgttc 1951561 aattttgttt tgatcattca gaacagccac tttcggctca tggcttgccg cttcttgatc 1951621 agacatcatt ttgtaggaaa taataatgac cttatctcct tcctgcacaa ggcgtgcggc 1951681 tgcaccgttt aagcatatga cgccgcttcc ccgtttacca ggaataatat acgtttcaag 1951741 acgtgctcca ttattattat tcacaatttg tactttttca ttaggaagca ttcccacagc 1951801 atcaatgaga tcttcatcaa ttgtaatgct tcccacatag ttcaggtttg cttccgtaac 1951861 agttgccctg tgaagtttgc cgctcatcat tgttcgatac atattatatt ctctccattt 1951921 ctcgaatatc aataatgata ttatctatta aacgcgcttt tgaaaaagca actgcaacag 1951981 cgagaatcat ctttccagca atttcattca caggctcgag ttccggatag gaataaagct 1952041 ctacatagtc tatggttccg ctagtcgttt caatgatatc ttttgcagct tttatcaccg 1952101 cttcaggatc tctttcaccg gcttggacaa gttccgcact tgtttgaagg gcccgataca 1952161 gcttaggcgc ttcttttctt tcctcagctg ttaagtatac attgcgagag cttttggcta 1952221 agccgtcttc ctctctgacc gtatcgacag gaaccaattc aatatccatg aagaagtcgc 1952281 tgattaaccc atcaacaaca gctacctgct gcgcatcttt taaaccgaaa taggcacgag 1952341 tcggcttgac tagattgaaa agcttcgtca gtacgatcgc gaccccgtca aaatgtcctt 1952401 ctcttgagcg cccgcataac acgtctgtgc gtctttctac atgaatcgtg acattctttt 1952461 caccgggata catatcatga gcatctggcg taaaaagaat atcgactccg gcgttttctg 1952521 caagagctgc atcccgctca atatcgcgcg gatatgcttc aaaatcttca ttagggccga 1952581 attgtgcagg attcacaaaa atactcataa taacggcgtc gttttcttgt cttgctttgt 1952641 ctgctaaggt taaatgcccc tcatgcagaa accccatcgt cggaacaaat ccgattgact 1952701 tgccctctga atggtattgt tttatggctt ctttcagctg tgaaatatca gtaatctgtc 1952761 tcatcttatt ttcccccgta caagccgtca agcactgtct ggttcatttg aaaggaatgc 1952821 ttttgttcag ggaaagcacg atgtcttaca tcctgaacat atccgctgat tgctgtttcg 1952881 atggtttcat caatgcgcgt atattgcttt acaaatttag gtgttctctc aacaccgtgg 1952941 ccgataatat catgataaac gagaacttgt ccgtccgctt tcacaccagc cccgattcca 1953001 atgaccggta tgcttagcgt ctcggcaatt ttggctgtga gttctgccgg cacacattcc 1953061 agcacaagca tcatagctcc tgcttcttcg cattttatac tgtcttctat taattttttg 1953121 gcgctttgtt cgtctttgcc ctgtacttta tagccgccca gtacgccgac tgactgcggt 1953181 gtcaaaccta agtgactgac tactggaatg cctccaagcg tcaatgcgcg aatggattca 1953241 aacacgcctt ctccgccctc aagcttcagt gcgtcagctc cgctttcctg aacgatagcc 1953301 gctgcatttt tcagcgtatc ttccttagac aggtgataag acataaacgg catatctgtc 1953361 acaataaagg tattcggcgc acccctttta acggcttttg tatgatggat catgtccgca 1953421 actgtcacac cgacagttga atcaaggccg aggacgacca ttccaagtga atcaccgact 1953481 aaaatcatgt caactcccgc ttgttcagca agtttagctg ccggataatc ataagcggtc 1953541 agcatgacaa tcggttcttc agactccttc atttttagaa aatccagttt tgttttcatg 1953601 ttttctcctc ctcatgttta gaggagatga tctgccgttt tcttctgcaa gccaaaaaac 1953661 cttccgttac aacgagaagg attcttcact ttctaaagtt cggcgagttt catccctctg 1953721 tcccagtcct tttttggatc aaggcagact gctgcaatgt ctatctattt taataatagg 1953781 tgcagttcgc aggcgatact gcccaatgga agtataccaa aatcaacggg cttgtaccaa 1953841 cacattagcc caattcgata tcggcagaat agattttttt aatgccttcg ttcgtttcta 1953901 aaagcagaac gccttcatca tctataccta acgccttacc gtaaaaggtt ccgtttaacg 1953961 ttctggctct catattagtg ccaataccga gcgcatagct ttcccataaa agcttaatcg 1954021 gcgtaaatcc gtgcgtcata taatcccggt accgtttctc aaagcatagt aaaatatgct 1954081 ggatgacgcc ggcccgatca attttttccc cagcagcttg gctgaggctt gtcgcgatgt 1954141 ccttcaattc atctggaaaa tcattaggct gctggttaac gttaatgccg atcccaatga 1954201 tcactgaacg tacgcggtct tcttcagcct gcatttccgt taggataccg actgtttttt 1954261 ttccgttaat caaaatatca tttggccatt taatatccgt ttggatgcct gctgcctctt 1954321 ctattccctg cacaacagct actgcagcaa gcagagtcag ctgcggtgtt ttttggagcg 1954381 gaatgtcagg ccgcaaaatc aggctcatcc aaacaccgtt tccttcttga gaatgccata 1954441 ccctagacat tcggcccctt ccggctgttt gtttgtcagc caccacaagg gtgccttccg 1954501 gtgcgttatt attcgcgagc tcatgagccg ttttttgcgt gcttgaaaga acgtcatggt 1954561 aaataagatg ctggcccatc acttccgttt ttaatccaaa acgaatttcg ctttcactga 1954621 gttttccggg ttttttgatg agccgatatc cttttcttct aacggcttct acttcataac 1954681 cctctttccg aagctcttca atatgcttcc acacagcagt tcttgaacag ccgagagcat 1954741 cactgatttt ttggccggaa ataaattcat tgccggcctg agaaaataat tcaataaggt 1954801 cttttcttaa tgttgaccgc atgtcttcag ccactcctct atgtgtttct tttgattgga 1954861 gagcttccct gtcacaacag cctgctcgat ccactgtaat tcttctgaca cccattttcc 1954921 ggccggccgg tttcgaagcg caagcaagtc cttacccgtg atatcaagat ccttaaggct 1954981 tttgatcggc aggttttgat aagcgtactg aatgtccttc agtttctttt catccagttt 1955041 ttcgttttgc cgaagctgcg atattttggc cgctgagagc agtgcttttt tcccagctct 1955101 gtacattgtc attgcgtcaa ggctctggcc aaacgtatcg gcaatgtgaa tggcttcctt 1955161 gatcactttt cccgggagct tccaggcttt caggaaaagg ggcgcgtctt tcaaaactat 1955221 gccaaggtta attaaaagag cagcccaaag ctcctcacgg gatgttaaag agaagaatgg 1955281 aaactcactc gttgaaatca ggttttctcg tttatgataa aaaccaggaa gctcttcata 1955341 caatctcgtt tgaatgagtg tttgaagcgc ctggcgagaa gctcttccct gcagcaattt 1955401 ctcaaactct atagtttttc gttcgactga aacatgggag aggagtgatt tttctttcgc 1955461 aatggcttct tctgtttccg gtgaaagcgt aaagccaagc tggctcataa agcgtacggc 1955521 tctcagcata cgaagcgcat cctcttgaaa tctatcctca ggctttccaa cggttcgaat 1955581 cactttctga tcaatatctt tcttgccgcc aaaataatca agcaccttcc cgtccgctgt 1955641 catggccatc gcattgatcg ttaaatctct gcgttttaga tcctcttcta atgatgagat 1955701 aaattgcact tctgacggtc ttctgaaatc aacataatca gattcagtcc ggaatgtcgt 1955761 gacttcatag gtttcatcct cccagagcac aataatggtc ccgtgctctt tgcctacatc 1955821 aacagtccgc tgaaacagcc gttctacttg atcaggtgcc gcatctgtcg cgatatcgac 1955881 atctccgatc gttcgtttca tatagctgtc acgaactgcg cccccgacaa aataagcctg 1955941 atggcccgct tcgattaaga tgcggagcac gggaagtgct ttgataaaaa ctttttccat 1956001 gtgatcactc cggttctgct aaatcggcat aaatctgttc atactggctg acaatttttt 1956061 tagaagaaaa ttcattttca agcatctcta ttgccgcctt tgtaaaacga ttgcttagct 1956121 gttcatcttc taaaatgctc atcgcgcggg ctgttgcggc cgtaacatca ccgacatcca 1956181 ccaaaaatcc gctcacattg ttttttataa cctcagggat accgccaatg tttgttccaa 1956241 tacaaggcac tccgcaagcc atcgcttcaa gcaggacaag gccaaagctt tctttttcag 1956301 atagcagcag cttcaaatcg ctaatagaat aaagatcttc aacacggtct tgatttccaa 1956361 gcattaagac ttggtcttcc aagccatatt ttctgataag ctcgcaggct gtcgatttct 1956421 ccggaccgtc tccgactaaa agcagcttcg ctttcgtttt gccagcgata ttgcggaaca 1956481 cacggatgac atcctgcacg cgtttaactt ttctgaagtt ggacacatgg atgacgactt 1956541 tttcatctgg taaaattcca tgtttctctt taattgccgc tgtgtttttc ttcagataca 1956601 cgcgctcgtc tataaagtta taaatcgttt caattttttt ctccggttta attaaatcgt 1956661 atgtttcagc cgcaagcgct gaggagacgg ccgtcaccct gtctgatgac tcaatagcaa 1956721 aacggatcag atcttttaga gacggatcat aacctaacac cgtgatatcc gtgccatgca 1956781 aagtggtaac aatgccgata ttgcgtttca gcatttgttt tgcaagatag gcgcaaacgg 1956841 catgcgggag agcatagtga gcatggataa tgtctaaatt ctcccgttcc gccacctcag 1956901 cgattttgct tgccaatgtc aaatcatacg gaggatactt aaaaacagca tattgattaa 1956961 cctcaacttc atgaaaatga atattgggat gatatgtatt cagtctaaac ggaatgcttg 1957021 atgtgatgaa atggatttca tgtccctttt cagcaagctg cttccccagt tctgtcgcaa 1957081 tgatacctga gcctccaacg ctcggatagc atgtgattcc tatttttagt tttctcattg 1957141 ttcgccccca agcacatcat gatcaagcat cagcatccgt ttggaaaaga aaccttcggc 1957201 atactccacg cccgcttctt taccgtaaag cttttctctc gcttcaacga tttcaatata 1957261 cccattcgtc agaggagtag aaacggaatc ctttgacggg ataaactggc ttttgtaggc 1957321 gttgaggctt tgtttctttg cctctattgt atccgagata tcaataacaa aatccggctg 1957381 atgaaaacca tttatcatat aatagtaaac cttgctgact ttatgcgccg gaaggctttt 1957441 ttcgtcttta tatttatgga ttccggcgga aaagatcgct tcttccacca gtgcagccgc 1957501 attgccgtga tccggatggc gatccttttt atacggcata aaaaccgctt ttggccgaca 1957561 gattctgatg acagtgacaa ttgaccgaat tgcctgatca ctcattatta ggccgcggtc 1957621 tggaagcgtt agctgaattc ttttatctgc gcctaatatg cgggctgctt cagctgcttc 1957681 ttctttacgc aaactgaccg taccgttaga agagagttcc gcttctgtca aatcgcatat 1957741 cattactttt ttttcctgtt tgacaaactt cgctattgtg ccgcccattc cgatctcgac 1957801 atcatcactg tgggcgccaa aagcaagaac gtcagcatta tacattcggc tcttctcccc 1957861 gaagaaggtc acggaattcg aaaacacctt catcaagtgt gcgcacaaga atttccgcag 1957921 tacccatatt tgtggcgagc ggaatggaat acacatcaca taaacggatt aatgccgaga 1957981 catccggttc atgcggctgc gcggtcagcg ggtcgcgcaa aaaaatgaca agatcgagtg 1958041 cattggcagc gatcagtgca ccgatttgct ggtctccccc taaagggccg gattgaaaac 1958101 gttcaatttg aagacctgtc gcctcatgaa ttttcaaccc tgtggttccg gttgcgtata 1958161 gatcatgatt ctttaaaata tcccgatagg cagtcgtaaa ttgaaccata tcctgttttt 1958221 tcttgtcatg cgcgatcaaa gcaattttca ttgtttatcc ccccgtctaa tcaatgatat 1958281 tttctaaacc atacacaagc tgatcaatct tcatgacttg ttcgactgac agtttaacgc 1958341 ctgacatgaa agaagcacgg ttataagaat catggcgtat ctgaagcgtt tggccatcca 1958401 tgccgaacat gacctcctga tgcgcgatca gtcccggaag acggacgctg tgcaagcgaa 1958461 taccgttttg ctccgctcct cttgctcctg ggagaatttc tttttcatcc ggatgtcctt 1958521 gctgcttttc tttacggact tctgaaatca tttccgctgt tttaagcgca gttccgcttg 1958581 gtgcgtcaag cttctggtca tgatgaagct caataatctc aacatcctca aaatagttgg 1958641 cagccatttt tgaaaatttc atcatcagta tcgcaccgag cgcaaaattt ggcgcgatga 1958701 tggctccgat ccctttttct tctgttaaag atgtgagctc ttttaaatca gcttctgaga 1958761 aaccggttgt tccgacaact ggacggactc cgtgctctaa tgcaattttt gtatgtactt 1958821 ttccgatttc gggcgttgtt aaatcaatca agacatccgg ttgtgtttct gtaaaacagg 1958881 catggatatc tgtgtaaatg aaagcatctg actcaacagg catcacatca gataattttt 1958941 gctgatcgta tgtatggtct atggccccta caaggtcaaa atgtggtgtt cgttctgcca 1959001 atttaacagc ttcctgcccc attcttccac gcggtcccgc aatgactaat ttaattgttt 1959061 cgtttgacat cttgatctcc tctactttcc ttcttctttt ctggtccagc gatctttatc 1959121 tcttgtatta aatttatgca tgactcggtc gtgagcttcc tctaaagaga tatcaagaga 1959181 gttggctaaa caaaccaata caaatagcac atcgcctatt tcctcttcca tgcttttatc 1959241 atcttcagtc gctttttttg gtttttctcc ataacggtga ttcacttctc tggcaagctc 1959301 gcccagttct tcagtcagcc tcgccatcat ggccagcggg ctaaaatatc cttctttaaa 1959361 ttggcctatg taacggtcta cttcagcctg tatgtctttc attgttttat cactcactga 1959421 acgaaacctc ctatcatcct cttacatgtt agctaattca gatacgtttg acaaatgttt 1959481 aagcacgttt gctgttttct ttttcatcca ctataatata aacgctatct aatggaagga 1959541 aaaggggttt tgtgtgatgc ttggagaaat tagattaaaa aacatatttt ttattttaat 1959601 cggagcggca attttttcat ttggcttggt tcatttcaat atgcagaaca atctggctga 1959661 gggcggtttt acaggtatta cacttttgct ttatgccctt ttccacatca gcccctctat 1959721 atcgaacctg gtgttgaaca ttccgatttt ttttattggc tggcgtttgc tcggcaggac 1959781 aatgtttgtt tatacccttg tcggcactgt agccttgtct ttgttcctca gcatctttca 1959841 gcgatatgaa atccatatgc cccttcagca cgacttagcg ctcgccgctt tatttgccgg 1959901 cgtattcatc ggagccggac tgggtattat ttttaagttc ggcggtacga caggcggtgt 1959961 tgatatcatc gcacgtttag tgaataagta ttttgggatt ccgatgggca gaacgatgtt 1960021 tgctttcgat gcctgcgtca tcattttgtc tttgcttact tatctctcct ataaagaagc 1960081 gatgtatacg ctggtagctg tatttgtagc ggcaagatta atcgatttta ttcaggaagg 1960141 cggatacgct gctaaaggcg ctacgatcat ctcttcgaaa aacgacctga ttcagaaaaa 1960201 gattcttgaa gaaatggaac ggggcgtcac cattttgaaa ggacaaggtt cctacacaaa 1960261 agaggatata gatgtacttt attgtgtggt gccgaaaaat gaattggtga tgctgaaaag 1960321 cgtgattaac tccattgatc cccatgcctt tgtagcggta agcgatgttc acgatgtgct 1960381 cggagaagga tttacgcttg atgaaaataa aaatccgctt ccgcgctgac atgtaataga 1960441 aaaaaggcgg ctgaccgccg cccctcatcc ttatttaggg tagtcccttt ttttcagctt 1960501 gtttttttcc gccttgtact ttctgtaacc gacataggta agagcagtaa tgatgatact 1960561 gccggttgta atgatcaccc agagtaaaga cggatcggca tcatcctcct ccaccctgtc 1960621 aaacacattt ttcaggtcat gctgaagaag ggaaagccgt tcaagcttcg tgctctctgt 1960681 catttgctga aattcctctt gctcaataac atctatatgt tttccgactg tttcaagctg 1960741 atcctctgat acatcgattg taagactggg gtaaatcaag tcatataaac tgataaattc 1960801 attccatttt tcatgaaagc ttgtgcttcc attcttttgg acatctcgct tcagttcagt 1960861 aaaagcttcc ataatcggtt tttccagtga gccccaaagc gggtcagacc gattgtcaac 1960921 cgcatccatc agcattctga actgcgcggc tgctctgagt ttttgtgtgt ctgatgtatc 1960981 agcttgcttt aaactccgaa ccatatcatt atagcccaat gtgatttgac gaatttgggc 1961041 tcccgttagc atggggtctt gctgtttttt ctcagcggat tttaatgttt tttcaaaata 1961101 ctccaagact tgaagcgcct cttcatattt cgcctgtcgg gtcatttgaa agactgtatc 1961161 ggataaatca ttcaattcct cgaggcttcc ccgctctgca gccttggcat ttccattata 1961221 aaaaataagt gcaatcaaca aacagatcgt cagctttcgt ttcatgcagg tccctcccac 1961281 tctctctcct tacagaatat gaagaaaggg acaaggatag accaacattg tctttacatc 1961341 agctcaagct tcgtttgctt ttttgagacc acaagaaagt aagcaagcgc gattgaaaag 1961401 atacttagcc aaaatgttcc gtatcctatt tcagtcatat aatcagaaag catagagtat 1961461 tgcggcatca tatcaaacaa gtagtcaatg acatcgttat gcagtgtcca gactgcagca 1961521 attgcaagat gccaaaatga aaaacgaaaa tacggactgt ataatacgcc ttgaactgcc 1961581 attgcaaaat gcgaagcaat tagcatgtag ccctcccacg gcaagtcacc agttactgca 1961641 agcacaagaa aattcatagc caccgcccat aggccatact ttacgagggt aactagcgca 1961701 agcgcctcta aaagcggagc attccgtttc atgagaaagg caagcagcac aaacagaaag 1961761 aaaaacgttg ctgtcggact gtccggaaca aaaatcagga aacgggccgg tgtctccaaa 1961821 agctgcggca agtaccaata gtagccgtaa accgttccca gaaaattaat ggctaagaca 1961881 agaataagca tcggccgctg ccctaataca tattgaaacc atttcacatc gaatcaactc 1961941 tcagtctgta aaaataatat gtccatataa aaaagctgac gccgggtcag cttttgataa 1962001 taaaagtata tccttccatt tgacaattca caatacgtta ttttgcggtt gtttcagaaa 1962061 taaattttgc aagttcttcg agctgcttat catttccttt gaacacaccc gccggcattt 1962121 tgcctttccc ttctacagcg atttttttga tttcatccgg tttcagcccg ctgtcaacca 1962181 atgaaggccc ggccgctcct ccctgaaggt tatccccatg gcaagaaata cagccctgtt 1962241 ccttaaaaac cttatatcct tctgcattgg tgtcaatgtc ggcttctttt gtaattttcc 1962301 cctgttcttc tgccttggcc cagtcatgag tagcaactga ctgccacgtc aaaaatacag 1962361 cagcggaaat ggccagaagc atcataccga cagcgaccgg acgcttccac ggccttcttt 1962421 ctgtccctct gtctaggaat ggagccaaaa gcagggcccc aaaagcgaga cctggcataa 1962481 tcatggcgcc gaccactgta aagcttccgg cggcgtattc atacttcaac agctggtata 1962541 agaaaagaaa ataccaatcc ggcagcggaa tataaccagt atcagtcggg tccgccatcc 1962601 gctctaaagg cggctgatgc acaatcgtca aaacgagaaa accgatgaga aagacagctc 1962661 caaccatcca ttcctttaac aagaaatttg gccagaaagc ctctgtttta cccggatact 1962721 ccgaataatc cttcggtata ttcggctttt tttcagccgg tatccttgag tcgcctacaa 1962781 atttcatccc tttgccccgg tgcatgtcat cccctccctt ttattcgcag atcaagagtt 1962841 taaagcggtc ctgaaatccc ctgcttccgg atcataataa aatgtgcagc catcagcccg 1962901 aacaatgcgg caggaagaaa aaatacatgg atcgcaaaaa acctagtcag cgtttgggcg 1962961 cctacaatat ccggatgccc tgcaaggagc gttttaactt gcgttccgat caaaggcgtg 1963021 gcttcggcga tctgcagtcc gacttttgtt gcaaacagag ccttcatatc ccaaggaagc 1963081 aagtagcctg taaagccaag accgagcata acaaaaaaga tcagcacacc gacaatccag 1963141 ttcagctcgc gcggtttttt atacgcgcct tggaaaaaga ccctcagcgt atgtaaaaac 1963201 atcatcacaa tgaccaggct cgcaccccag tggtgcatcc ccctgacaat ctggccgaat 1963261 gccacttcat tttgcaaata atataccgat tcccaggcat ttttgatatc aggcacataa 1963321 tacatcgtta aaaacattcc agataatact tggataacgg ttacaaaaaa cgtcagtccc 1963381 ccaaagcaat acacaaacgc agagaaatga tgggcgggat tcacatgttc cggtacttcg 1963441 tgatcggcaa tatccctcca catcggtgta atatcaagcc gctcgtctac ccagtcataa 1963501 attttgttca gcatgtcacc cttccccctt aggctttgct tttccaagat acaggaagcc 1963561 gtcttttact tcttgctcat aatgatcaag aggcgcaagc ggcggcgtgc cagggacatt 1963621 ggtgccgtcc ttttcataga gtccgtaatg gcatggacaa aagaatttat tcgggttttt 1963681 aggatcacta ttccagttca ccgtacaccc taaatgctta caaattggcg aaagtgctac 1963741 aatttcatcc ccgtttttga agacccaggc tgatcttgac tcttctgact cataccaggc 1963801 atcgacttga ttaattttaa aatcaaagcg ctgcggctct tttgtcaact catcaacgct 1963861 gacaacctga accatatcct gcttccctgt cgattttaat accgggtcga gtgcgaagcg 1963921 aaccataggc atgagcatac tagccgccat aaaacctcct acgcctgtga gcgtataatt 1963981 caaaaattga cgtctggata tatcatgttt tccgcccatc tcttctcccc cctctaagtc 1964041 acccctgcaa actgactaaa atagaaaata ttgcaataac tctagacacc ctcataatat 1964101 atgaatctct cagcaaggtc aatatagcca aaatattgtt tataaggaaa tgtaagtgtt 1964161 tttataaagt gctccataac tgtaacaaaa cgttcaaaat ttcagcagtg cgttcatcca 1964221 atatttttct ttttaaagag tcatttaaat gctctaatgg aacagacgat gtaacaatca 1964281 ttttgcctaa cgcatcctca gctctccaac tttcgtcaga tgtgagcagg acaacatgcg 1964341 gaaattccgt tatcagctct tcccgcaaat ccttaagccc ttgaacggtt atttcatttc 1964401 tatcaacata tgtataaggc ggaagtaaat atacccgtcc ctttaactgc ctttcaagtt 1964461 cttctgagag aagctgcgta aactcgcctt tctccgccgc cattttaaaa tggttattaa 1964521 cccttatgtt aattaatggt atgacagcgg tatcaatgta atccttagct tgtaaatagt 1964581 ccttggcatc agtgattctc cacctcatcg ttctccccct ttacggcaac aagccttgca 1964641 attcactgca aggctggtca tattatgtga gctgatttaa ttggcgcgat aattgttcaa 1964701 atgcctcttt atcatgacga tctaacgcgt cgtcaatgtc ttttaataat ttttctcttt 1964761 ggaatgtgga aatagcgtgc tctaaaatct gttccgccaa tccctgatct tttttattct 1964821 caaaaaggtt tttcggaata tgcgggttgg actccagcac cgccgcatat tcaggtgagc 1964881 tgtaagccga acggaaatta agctggataa acaaatcctg ctgtttattt aatctaatat 1964941 catgaaaaga tttttccgcg tcggtagtca tgacattctc tttatagaac cggaacggaa 1965001 cttcttcaac acaatgtgtt gacattataa tgcctctcgg gcaaaattca gcctgctcca 1965061 caaaatgaac cttctccatg agagaatcat ggctcattaa gtagttcaag atccaaacgc 1965121 actctcggcg ctttaactga taatggttta aaaaccaacg gataaaatct tttttctcat 1965181 tgacagaaac aggggtctgc atgtaattcc ctcctctatc gttcgtataa tctatatact 1965241 tatatgttcc acatgaatgg ttaatattcc tgcttatcta gaaaattcat cctcgattcg 1965301 caaaatcgtt tcttcaagct cttcattggc tccgtccatt tcaagaacct ttttcaaaag 1965361 cggcagcgct tctttttgaa gaccttcttc taataggaag cttgcgtatt catataagaa 1965421 atctctatcc tcccggtaat gaagataggc agcctcaaag gattgttttg cttcctcgta 1965481 ttgctctaat tcagtatatg cgcttgcaag ataccaattg tatttaggat cttcttcacc 1965541 gtagcttcga acctcttgaa taagatcaat gatctgatca taatcctctt ctttgtgata 1965601 cacggcaaga agtgtatgaa gcgcctcgac aaagcccgga tcaagcgcaa gcgcctcctg 1965661 aagcagcttc ttcccctctt ctgacttccc gattttcaag gccattttgg cggcataaag 1965721 gaaaagttct ttgttatatt catcatatct gatcccctct tttgccgttt ttaatgcctc 1965781 ttcatacatt ccttcagctt catagctttt cgagagcggc atataaagtg aagtataaga 1965841 tggatcaagc tcctttaaat cagacagctg cttaatagct gttttcacaa gccccgcctg 1965901 taaggctgta aaaccatagc cgaaaatcgt attaggatca ggattctcat cgacagcttt 1965961 ctcataccat ggaatggcat cctcaaattc acctgaggca cttaacgatt ctgccagtct 1966021 ttgatggaca ttaacgcccc cgatctcact ctgctcctca gccgttgttt taaaatattg 1966081 aaccgctttt gcataggctc cctgagcaaa gtaaagttct cccagtgcaa aatcaataac 1966141 aggttcattg tccagaatgg actttgcctg gaaaagcttt tgttcactga cttcgaataa 1966201 cccctgcatc tgataaagat ccgccataag cagcaaactt tccggatatg atggatctgt 1966261 ttccggaata gtctccagca cagcgagggc tttttcttct tcgtcaatat ctattaaaag 1966321 ttcagcgtag aaattcgtca gttctgtttc atttggatat aaatcatgta gatcactaat 1966381 cagtgaaatg gctttttcta catcgcccca ctcgtaataa agctgggctg caatggcttt 1966441 atcttcatca tgcagctgtt tttcagcctt cgagagcgtg ttgaggcctt tttctgtttc 1966501 acctgcttca actaatttta tggcttcttg aatcaatgta ttcaaatcgg accggtcctt 1966561 tcttttccta tacaacatca accatacaaa aaaagcttta tttgttcggg ttaatcttat 1966621 cataattcag acgaatgccc ccggcaaata agatgcttct gtacggaagg gaattattga 1966681 gtcttattag tttaccaaaa gatcttgaga tagaaaatga aaaaaggaag atcgccctct 1966741 gtacagtaaa gcagctcttt gacctgccgg cttgtaagta aagcacatcc ccccttttcg 1966801 tttttctatc cgttctataa gacaagctat gttttttcgc ctcgaattat gatctgcata 1966861 aaaaatcctg aagtaaaact tcaggatttt ttcgaaagct tatttaaatg ctcgaagaag 1966921 gttggataag aaacgtgaat ggcatccgtg tgctcgattt caatcggctc ctccgttata 1966981 caggaagcaa taccaagcat cattccgatt cgatgatctc cgtggctgga cactgcagcg 1967041 ccgcctttca acgtttgttt gccataaacc ttcattccat ctgctgtcgg ttcaatttca 1967101 gcacccagct tgcgaagctc agaaacaaca gtatcaatac ggtttgtttc tttcactttt 1967161 agctctgccg cgtccttaat aacggtggtt ccttccgcct gagtcgcaag aagcgcgatg 1967221 atagggatct catcaattaa acgcggaatg atatctcctc cgatttcaac tgcctttaga 1967281 gatgacgttt ctataatcaa atctccataa ggctctgcac cgctatcagc agatggtttg 1967341 atttcaagtt ttgcccccat gttttgaagg acatcaataa tacctgtccg agtcggattt 1967401 aaacctacgt ttttcaatac aattctgctg tttggaacca tcgcgccagc agcaaggaaa 1967461 aacgcggctg aagaaatgtc tccaggaaca aaaatatcag cagctgtcag tttctggcca 1967521 ccagcaatgg aaacactcgt ttgatcttca gaaagcttaa cgccaaaagc agaaagcatc 1967581 cgctcagtgt ggtcccgaga tttatggggc tctgttacag ttgttgtgcc ctcagcctgt 1967641 aatccggcca gcaaaacagc agatttaatt tgcgcgcttg caacaggtga tacataatca 1967701 attcctttta atgaagcgcc gctcactgac agcggtgtaa actctccgcc ggctctgccg 1967761 tcgattttag cccccatttt tttcaaaggc tcagtcacac gcttcattgg gcgtttcgca 1967821 atgctctcat ctccggctac cgcgctgtaa aaaggacggc ccgccaatat tccgagcatc 1967881 aggcgaatcg ttgtacctga atttccgaca tctaaaaggc tttctggctc tttcagggca 1967941 tcgattcctt ttccgtgaat cacgacatcg ctgctgcttt gctcaatgtg aacacccatt 1968001 tttctaaagc aatcgatcgt gctcagacaa tctgctcccg gcagaaagtt tttaactgtt 1968061 gttgtgcctg ccgctagcgc gccaaacata acagagcggt gagaaatgga tttatcaccg 1968121 ggaatatgta tttctccatg taaggtctgc accttatctc gtttcatttt ttccacctca 1968181 atcagcataa aaagtttcat attccgcccg ggcttcaatg cattgttctg cccttttgcg 1968241 gtcgtcatca gactgaaaac tgatccttaa aatcccgtta atatcctctc gtgtttcgat 1968301 aatgcggata ttcgtgatac tgatgcgctc cgcagctaag atcgctgtta tctcggatat 1968361 tacacccgga tgatcgggta catccacata taaatcataa aatgcaggta tcgctccctt 1968421 ctgccgaagc ggcagcccgt cgcgataatc cttggctgtt ttaaaataac gaaatagatt 1968481 ttccgcatct tcttgttcta catatgtacg gatcttgtca atttcacgaa tccactcatc 1968541 aaaacggtct aagattttat ctttattatg taataaaata tcccgccaca ttgccgggct 1968601 gcttgatgca atccttgtaa tatctctgaa cccgccggca gcaaaacgct taacaagcgg 1968661 atacaggttt tccgaatgat gggtttggtg aacaaggcta gctgctacaa tatgcggaaa 1968721 atgactgatt acgcttgtaa cgccatcatg ctcctctggc gacatttcca caaaatgggc 1968781 attcgtcccc ttcagcaggt tttttaactg ttccacagct tgtttgtccg ttttctggcc 1968841 tggcgttaaa atataaaatg cattttcaaa caggaactcc ttcgcagcgg ccactcctga 1968901 tttatgtgaa cccgccatcg gatgccctcc gacaaattga tagcggctag gcagcacttg 1968961 atcagcgtaa tcaaccactt tttgctttgt gcttcctaca tccgtaatca aaagctcatg 1969021 ttcaattcct gaatgagcca gctcttcaag cataaccagt gtttgttcaa caggtgtcgc 1969081 aatgattact gtagctgcct ctttcacacc gctaataaac gaatcagcac gatcgtctat 1969141 cacgcctaat tttaatgccg ctaccgcctg ttcatcagag atgtcgattc cgataatccg 1969201 tttgccggga tgattttttt tgatggctag ggcaatcgaa ccgcctatca atccgagacc 1969261 ggcgagcaat attgtatctt tcatttgatt catacgtcat cacctggttt atagactaaa 1969321 gaggtgatat ttgatcacct cttataaaat ttcagctaaa atggcaagta tttcttcatt 1969381 ttgctctttt gttccgatcg taatccggag tgatgtcggg aaacctaatg cgtttcctga 1969441 ccggacgata tagccttttt ccagcagagc ctgaaacagt tcatcagcag gacgtttaaa 1969501 gtcaattaac acaaaatttg tctgtgaagg gtagcacttt aaaccatgag ttttcgcaaa 1969561 atcataatac tgctgaaggc ctgcattatt ttgctcgaca caggaagcaa taaacgcttg 1969621 atcatcaagt gctgcaatcg ccgcagcctg gcccagacgg ctggtattaa acggctctct 1969681 cgccggctca atctggcgaa tcaggttctc gtcagcaatt ccgtatccga ctctgagcgc 1969741 tgccagaccg tatgcctttg aaaatgtgcg caaaatcatc aaattggaat acttgcttaa 1969801 gagcggcacg gtttccgggt aatcctctgc tgttacatat tcataatatg cttcgtcaag 1969861 aacgacaagg acacgagaag gaacgcgctc cagaaatgcg agtaattctc cttcagatgt 1969921 ataagtgcca gtcggattat tcgggctgca tatccaaacg acttgtgtct gttcgtcgat 1969981 ggcttctaac atggcgtcta aatcatgtga gccgtcggga cgaagtgcaa tttcacgtac 1970041 ttcagcacct tcaataaccg cattatgttt atattgcgga aaagtggggg cagcagtaac 1970101 cgtgtttgtt ttatcgttta aaaatgcccg gcagatgatc tgtatgattt catcagaacc 1970161 gttgccgaaa ataagtgatg tttcgctgac attgaggtgc ttactgagcc ttgtccgcaa 1970221 agcggcgcta tacccgtccg ggtaaagggc tagctgttga atctcatgat gaagcgcctc 1970281 ttttgcagcc tctgaacagc cgtaaggatt ctcgtttgaa gcaagcttca caactttatc 1970341 caagccatat tctgatttca ctgcttcaat cggctttcca ggctgataag gcttcagctg 1970401 ttttaaatgt tctttgatac gcaaatcagt cacctcattt taaactgtac aagccgctaa 1970461 acgccattgc ataatcctca aactcctgca gcgcctgatt tctcgtttca gcgctgatga 1970521 gccggtcctt taattcttct atttttctga cgagcgcact tcccactacg acaccgtcac 1970581 taatttcatt catctttatg acctgttcac ggtttgatat accgaaccct acagcaaccg 1970641 gaacagtgct gagattcttc acagtacgaa tgaacgggta cacggatgaa ttgaactcat 1970701 tgcggacacc ggtcacaccc agagaagata cacagtagac gaacccctcg gcttgttcaa 1970761 taatggtttt caaacggctt tcgcttgtcg gcgcaactaa agaaatatac gtcacctcat 1970821 ggcttttaca ttcctcttga aggctgttgc tttcttctaa tggcagatcc ggaacaagca 1970881 gaccgtcaat atgattttcc cgcagtaaag cgaaaaagta ttctttgttc aattgtaaca 1970941 caggattata atacgtaaag aggataatcg gaatattcac tccgtttttt ttcatttctc 1971001 cgcctaattc gattgccttt acgatattca ttccttgatc aagcgcccgc tttgaagccc 1971061 gctggatcac cggaccgtct gcaagcgggt cagagtatgc aacaccaagc tccaatgctg 1971121 tggcgcctgc tttttggagt gacttcgcca gttcaatcga aacctcagga actggatcgc 1971181 ccgccgtaat aaacgggata aacaattttt ctgatggttg aagatccaat ttaaacatgg 1971241 gctttcacct cttcttccaa tacattcatt aatgtgttga catccttgtc tccccggcct 1971301 gataaacaga cgagaatgag ttgaccgcga tccattcctt tggcgagttt gaatgctttc 1971361 gctaacgcat gggcagattc gattgccggc aaaatcccct ctttttctga caaaagcttt 1971421 aatgcatcca ccgcttcttc atcggttata ctgtcataag tgacacggcc gcttttatgc 1971481 aaatatgcat gctccggacc gattccagga tagtcgagac cggctgaaat agagtagggc 1971541 tcaataattt gcccgaactc atcctgaatg agataagtca atgaaccgtg aataacccct 1971601 acggttcctt tcgaaatagt ggcggcatga agaggtgtat caattccttt tcctgctgct 1971661 tcagcgccga tcagttcaac atcttcattt aaaaatgcct gaaacatacc catcgcattg 1971721 cttcctccgc ctacacatgc cactacttta tcaggcatag tgccttcaat acgtttcaac 1971781 tgatccttcg cttcctctcc gatcattttt tgaaattcac ggaccacttg cggataagga 1971841 tgcgggccga caactgatcc aatcatataa aagtgatcct cacaatgctg aacccagtac 1971901 cggatcgcct catttgtggc atccttcaat gttccgtttc cgcttgttac aggcactacc 1971961 tccgctccaa gaagcttcat gcggaaaacg ttcagagact ggcgggcaac atcctcttca 1972021 cccataaaca cagtacagga aaagccgaat ttggctgcaa ctgttgcagc ggcaacacca 1972081 tgctggccgg caccggtttc agcaatgatt ttcgttttgc ccattttttt agcaagcagc 1972141 gcttgaccta gcgcattatt gattttatga gaacctgtat ggtttaaatc ttctcgtttc 1972201 aaatagattt tcgcgccgcc taagtattca gtgactcgat cagcgtatgt taatgcagtc 1972261 gggcgtccgg aatagtcctt taacagctta taatactctt cacgaaaagc gggatcatcc 1972321 ttgatttgtt taaatgctgt ttgtatttca tctaacggct gcatgagtgt ttccggaaca 1972381 aactttccgc caaaatcacc gtatctgcct atttcattcg gatatggata catatcggtt 1972441 catcctttct tctaaaagcc tcatcagatt ctgatctttt tgtccgtttt tttcaattcc 1972501 gctggcaagg tcaattcctt ctggctgcca tttcaatagg cgtgtgatgc tatccggatt 1972561 cacgccgcca gcgataaagc agcgtttacc aatagccgcc tgctgatatt ccggcacaca 1972621 ttcccaagaa aatgcaacac cagttccgcc tctagaccct tttacagatg aatcaatcac 1972681 aaagccgtca acattatctt taaagcgggc tatttcttga gttgtgttat cttgatggtg 1972741 aagcgccttc catatttcac agcctgtcag cttgcgaaga gcagcagcat ccgccggttt 1972801 ttcatcaccg tgaagctgaa tgacgtcgag cttcaagctc ttggcaatac gtgacatcgt 1972861 ctctattgat tcattaacaa aaacacctgc aacctgtttt tcgacacgaa cttggttcag 1972921 ccattttttc acatcttccg gagatacttt tcgtttgctt tcagcaaaaa taaatcctag 1972981 gtaatcagcc tgtgattccg ccgcaagctg caaatccttt agtgaccgaa taccgcaata 1973041 ttttaatgcc ggtttcttca caacctcact ccctaaacaa agcatggatt gctttacgct 1973101 gagaagtttg tctcatcaat gattcaccga taagtacagc tcgtgctcca tgttctttga 1973161 caaatgttaa atgttctaaa gaaccgattc cgctttcgct gacaagcagt gattctttcg 1973221 gagcaagaga tgcgatttgt tctgtctgca tgatagaggt ttcaaaagtt tttaggtttc 1973281 ggttgtttat gccgagaata tcaggcgtga atactttcaa tatttgttct agcgttgttg 1973341 catcatgaac ctccactaac acgtccatct ccttttcacc tgcttcaaga tataattcat 1973401 gaaggtgtaa gggatcaagc acttcgccga ttaacaatat ggcatccgct ccgattcttc 1973461 ttgattcctc cacttgaaga gaatcaataa taaaatcttt tctgagtaca ggtatcgaaa 1973521 cagcgcgctt tacgtctgat aaatagctgt tttccccttg aaaaaacggg gtgtctgtta 1973581 aaacggaaag cgcatctgct ttcgcagttt catagtcttt tgcaatccgc acaggtacaa 1973641 aattctcttt aataagccct tttgacggcg acgctttctt cacttcagca atcaacccga 1973701 taaaccgatt caggcttgcc agcgcctctt taaatgaacg tttttcgaaa ggctgctcta 1973761 ccggcagaac cagtgttttc acttcttctt tcttttgttt gatgattttt tcaagcatag 1973821 atctcttcct ctttctgctt tagtcgttca agctgcgcgg cagcgcctcc gcttgtaatc 1973881 gtctctaacg ccagctccgt tccttccttc agtgaggcgg taattcccgc cgtgtaaatc 1973941 gcagcacccg cattaaaagc cgtaatagat aaagcggaac tgctgctttt attttcaaaa 1974001 atattctgaa tgagataagc gctctctttc ggagactgca cctgtaaatc ttcaagtctg 1974061 ccatttgtga aaccgaaatc ttcgggtgaa acggtatact cccggcgctc tccgtccttt 1974121 aattcaatca cgtcggtcgg tgctgtaatt gaaagctcat ctaaaccgtc acggcttgat 1974181 acaaacataa cgtgcttcgg ctgaaacgtc tccagtgcgc ttgccatcag tccagctttt 1974241 tcaacagaat agaccccaat cacctgacgc ttcgcctgta aaggattgct gagcggccca 1974301 agcagattaa ataccgttct gaaacctagc tcttttctag tacctgctac atgtttcata 1974361 gacgaatggt aaagcggcgc aaaaagaaat cccatgttgt ttgtttcaat gctgcttttg 1974421 accttttcgg gagtggtttg aatagaaacc tctagctcct ctaaaacatc agcgcttccg 1974481 cttttagaag agacagagcg attgccatgc ttagcgattt tcgcaccagc tgccgaggca 1974541 acaattgccg aggccgttga gatattaaaa gtggaaatac cgtctccccc tgttccgcat 1974601 gtatcaacaa tatcaggaag tccatcgact gtaagagcgt gtgcccgcat tgccttcaca 1974661 aaacccgcaa gctcttctgg cgtctccccc cgatgagcaa gaattgacaa tatccccccc 1974721 atttcagaag gagtcatttc cgctgccatc atcatattca tcagcgtttc agcctcaccg 1974781 gcagtaaggg tttttccgtc aacgcacaat tgtagaaatc tgttcatcag ctttatcctc 1974841 cttgctatga aacatgtctt ctgcaatatg aatcgttttc agcagcgcac cggctttatt 1974901 acagctttct tcgtattcgg cttccggaac agaatcagca acaatgccag cacctgcctg 1974961 tatcgatgca acaccgttct ttacactcat cgtgcgaatc gtaatacaag agtcgatatt 1975021 cccgtcaaac ccaatgtagg caatacaccc tccgtatgtc tctctcggtg ttggctcgag 1975081 ttcttgcaaa agctgcatgg cacggatttt gggtgcgcct gttaaagtcc ccgccgggaa 1975141 agcagacatc agtgcatcga caggatgaac cccttttttc aatcggcctg taaccaccga 1975201 gataatgtgc atgacatgtg aaaaggaaac aatttttgtg aactccggca cagaaacaga 1975261 accatactct gctactctgc cgatatcgtt tcgggcaaga tcaacgagca tgtaatgctc 1975321 cgctttttct ttttcatcct tcatgagctc aaccttcagt ctctcatctt cagctttgtc 1975381 tgcaccgcgt tttctcgtac cggcaatcgg atggatttct aagtgcccgt cttgaacgtg 1975441 tattaaccgt tccggagagc tgccgactat ttctctgtct agcagtttca tataatacat 1975501 atacggcgaa ggattgacga tcctaagcac tcggtataac tcaaaagcat ctgcttttat 1975561 cggcacctca aatttttgtg ataaaacacc ctggaagata tcgcctgctt ttatatagct 1975621 tttgattttt tctacatcag ccataaaagc cgatttttca taattagaag atactgtctc 1975681 aaagctgggt gtcttgtatg aatcagcaga aagaaacagc tcttttatgt ttttttggtc 1975741 catcattttt tcaatgagat tttgaagctc cagatgattt tgatggaata catccatttt 1975801 ttcgtttttt gtttcctctc cagtgagcct tgcatattgg ataaagtgga cgtttttggt 1975861 ttcatgatca tacgcaatta atgtccggca aacaaacagc atacactttt ccatgtctgt 1975921 ttctttggta tgcgaaggaa cagaaggctc aatcagcggg atcatatcat agcttaagta 1975981 cccgacagct ccgccgacaa aaggaatgcc aagctcaggt gttttgattt tgtatgtggt 1976041 attcatccag ttcagcactt cttttagttc atttcctgtg taaagagatt tgctgtcctg 1976101 atcagcggcc gaaaaacggc cctgctcttc tttaattgtg agaaatggat tcaggccgat 1976161 aaacgaatat ctggaccaag tggatgtatc gtccttgctt tcaagaagat acgtaatctc 1976221 cctgtcaagc ttctctatca tttgaatggg tgtcagtgta tcgactgtga aggtctccac 1976281 aatcggtatc gtgtggtggg acaagctgtc ctctaaaaat gcggaaatgt ttgattggaa 1976341 attcattgct ctcactcctt atggcaagga gaatgagaag atggcatgag aggataaaat 1976401 actatataac aaataaaccc aaaagaaaga cttcttttgg gtagaataaa cataatgtct 1976461 cagctcaact aaactcattc tctgctaccc tattctctaa ctcaactcat tctaattgct 1976521 ttatacacac tcttgtgtat ttctaagctg ttcttatcgt attacaattc agtatttttt 1976581 gtcaatgata aatcgggcct caatacgaca actttttcta aatatacatg tctgatctga 1976641 tcctgaggga catctgtctg gaccgtcatc atgactctta tgcacttttt cagaccgcct 1976701 gttacgtcca tttcctgcat acatgttacc ggtacatact gccatcctga aagctcgcga 1976761 acagcttttg ccgggaaaac agcgtgcaaa tcaggtgtag ccgacagaag catttgaaca 1976821 acatcttccg gttttgtatg attttcttct atgattttct ctaacagctg tttagttttt 1976881 tgtaaaattt cttcttcagt atcccgttca actgtagttg ctccgcgaat tccgcgaatc 1976941 atcatgatgt ctcctccaat cgccatttgt tcagccagct ctcaagttca tttctggaaa 1977001 atgtatgatc agcaactttc cctaattcgt tgagcacaat aaactgaatc ttcccgccac 1977061 gggttttctt atcattcatc atacggttca agagaaccga agtttccgtc tcttttctga 1977121 tttgacttgg ataacccagg ctttttagcc agctgaccaa acgttttctg tccatttcac 1977181 agcctacagt cttttcgctt atatataaag caaactgcat tccgagggct acggcatcac 1977241 cgtgagtgat ctgcccatat ccatattccg cctcaacggc atggccgagc gtatgcccaa 1977301 agtttaagta agctcttatc ccctcttctt tttcatcctg ctgaacgaca gacgctttaa 1977361 ttgaaatgcc tttaaaaatc atgtcattca gctgatcatt agtgatatca cgcagtgagt 1977421 ggatattcag cagctcctcc agaaacgctc tgtcatagat aaaagcgtgt ttaatcactt 1977481 ctgccattcc ggacctaagc tctttttcag gcagagaacg caggaaatct gtatcataga 1977541 gcacggcttt cggctgataa aacgcaccga ttagattttt tccaagcgga tggttcacgg 1977601 ctacttttcc tccgactgcg ctgtcatgcg ccaagagcgt cgtaggcatt tggatgaaat 1977661 caatgccgcg cataaaagtg gcagccacaa aaccggcaag atcccctaca acaccgccac 1977721 cgaatgcgat gatgcatgag gagcgatcca tatgaaaacg aatcgcttca ctctgcaatt 1977781 ttgtgtacat gtccatggat tttgcctgct ctccactcgg taccgtcact tttttcacag 1977841 gccatttttc ttgcagcaaa tggagcattt catcaccata caggcggtcc acttcttcat 1977901 ccgtgacaaa cataatcctt gttaaaggcc tgtttaaaga ggttaatagt tcgcaagcct 1977961 tttttctgat accttgtccg ataaaaacag gatatgacga ggaagcagtt tgaacatgca 1978021 gtgtcttcat taaaattccc tcgacagttt tctcatattc tccacatttt ctctaatgcg 1978081 gtcaatttga tctaatccga attgttcaac gactgcgttc gcaatttccc aagcgacagc 1978141 cgcttcagcg actacacttg ccgcaggaac agcacagctg tctgaacgtt caatgctggc 1978201 agaaaacggt tctttcgttt caatatcgac acttttcagc ggtttataca aagtcggaat 1978261 cggcttcatg actccgcgga caacaatcgg catccctgtc gtcatgccgc cttccagtcc 1978321 gccaagtctg ttagtagcac gggtgtatcc tttttcctcg tcccaaatga tctcgtcatg 1978381 gacttcgctt ccatttcgcc ctgctgcctc aaatccgatg ccgaattcca cacctttaaa 1978441 tgcgttaatt gacagaacag cggcagcaag cttgctatcc agcttgcggt cataatggac 1978501 atagctgccc acgcctaccg gcattccctc gacaatgact tctactattc cgccgatgga 1978561 atctccgttt gcctttgctt catcaatggc agccatcatt tttttgcctg cctcttcatc 1978621 gtagcatctg acaggagact cttccgttac acgctgcaag tcttcaattg acgtatactc 1978681 tgttttttca gctttaacag cgccaatttg caacacgtgg cccgccacct taatgccaag 1978741 ctcagaaaga atctttttag ctacagcccc tgccgccact ctgacagttg tttcccttgc 1978801 tgaagaacgc tcaagcacat ttctcatatc acgatgatta tatttaattg caccgtttaa 1978861 gtcagcgtgc ccaggtctcg gtctggaaat ctggcgcttc atttcctttt cttcatcttc 1978921 tgtaatcgga gcggcgccca tgatttttgt ccaatgcttc caatcgttat tttcaactac 1978981 gagagcaatt ggcgaaccga gtgtacgtgc atggcgcacc ccgctcataa ttttggcctg 1979041 gtctttttcg atctgcatgc ggcggccgcg gccgtgtcct ttttggcgtc tggcaagctc 1979101 aaaattgata tcttcctccg ttatgtaaag cccggcaggt acaccctcaa taatggttgt 1979161 cagttggggg ccgtgtgatt ctccggctgt taaatatctc atgacttctt ctcccttcat 1979221 cgcattaacg cttttaagta agactactat aacatatttt tcagcaaaaa gtcagtctat 1979281 cttttttgat aaaagaatgt atcggctggg actaggccaa atttctcggg attgaagatt 1979341 tgctcggtgc tgccgacaaa aagaactcca ttcttcttca agctatgtgc catttttaaa 1979401 tacagctctt ccttcgcgct ttctgtaaaa taaataaata cattgcggca cacgattaag 1979461 tcaaagtctt gttcataacg atccgccagc aaattgtgct ttttgaatgt aatattcttt 1979521 ttgatttccg ttttcacttc ataacttcta tttgcgtttt gcgtaaaata acgatctttc 1979581 acagatagcg gcacttcctg taaagaccgc tcctgataaa cgcctttttt cgctttttcc 1979641 aatgcttttt catcaatatc cgtcgctaaa atctgatagc ccggaagacc tttttgctgg 1979701 tccaaaagca tggcaagcgt gtatggctcc tcccccgttg agcaggcggc actccaaatt 1979761 tttaaaggcc tagaggtctt gattaacggc agaattgcag tctcaagaac ttcccatctt 1979821 ttataattac gataaaattc tgaaacattg atcgtcattc tgtccaatgt ttcatttaag 1979881 agagcttgat ccttttccaa tgccgcagca aagtccttaa agctttggaa cccctttttc 1979941 tcataaagtg acgttagcct tctcttcatt tgtgcttctt tatatagtgt taaatcgact 1980001 ccggttaatt gtttccattt cgttgtaaat acgctgtatg tatccatctc tactctccca 1980061 gtctcgctgt ctttttgtcc tagtatagct tgttttatca ggaaattgta ttgtttcaat 1980121 aaaaaaatca gcttttcagc tgattttaga tcgttgggaa aggcagaggt ctgatgcaca 1980181 ctgccattca accctttatt cactttaatg taaaccttta caaaacagaa caaaaaccgg 1980241 cggcgttata tgttgccggc tctgttgctt attttcacaa tgattaatag atccagcctg 1980301 ccataagctg ctgatatgat actaattctt cattcttaaa gaaaatgtta atctcgcgtt 1980361 ctgcactttc gagagaatca gagccgtgga tgatgttttt tccgacaaac atgccataat 1980421 ccccacgaat cgtaccaggt aaagcttctt tagggtttgt tttcccgatc agctgtctcg 1980481 tcacttcaat gacattttcg ccttcccaca ccattgcgaa tacaggtcct gaagtaataa 1980541 actcaacgag ctctccgaag aaaggcttac cttgatgttc ggcgtagtgt ttctcagcca 1980601 tttgttcagt cactctcatt aacttggcgc cagctaattg taagccctta cgttcgaatc 1980661 tagataaaat gtccccaatg agctgacgtt ggacaccgtc tggtttcacc atgataaaag 1980721 tcttttccat catattctcc accccatcat tatgtatgta taggctttca cactgcacac 1980781 cgaaatcgta acatctttct gataattaat caatccgggg cggagaaatt tcttaatatc 1980841 tacaaaaatt aaaattttct tttaccgata tattttgcga tggctgcaag agacgagcgt 1980901 gcgcgccctc gaggaagcgt gtttaatttc tgaaaagctt tctgcagata catttcgctt 1980961 actgccatag atgcttcaat tgcatctgtt tttttgattt cttcaatgat tggttcaagc 1981021 tgttcctgcg ttgtctcact gttaatcaat ttaagctggt tttttaatgc aggatttttc 1981081 agggcataca gcactggcaa tgtgacgttt ccttgaagca aatctcctcc tacgggttta 1981141 cccagctctt cctcagttga agtaaaatca agaatatcat caataatctg ataagacatg 1981201 ccgacgtaat acccaaacca gtacaatgcc ttatgaatct tctcatcagc tccagacgca 1981261 atggcaccaa gctggcagct gaccgcgatc aagagagctg tttttctttt gatacggcgg 1981321 agatacgttc tgagattttg ttccatgttg tatttgtctt tgatctgctc aatttcccct 1981381 agacaaactt caacgatcgt ctgtgacaaa atcctatggg ctttcggttc gttaattctc 1981441 gtcatcattt caagagatcc cgcaagcata taatcgcctg tgtacatcgc aatacgattg 1981501 tcccactttg ctttgattgt cggttttcct cggcgaagct ctgcatcatc aatgacatca 1981561 tcatgaacca aagatgccat gtgaatcatt tccagagtga cggcgacata tttaatctta 1981621 ttaatatcat aatcgccaaa catgccagaa agcagcacga aaacaggccg aatacgtttc 1981681 cctccggcct gcagcaggtg aagacctgcc tcgcttaaaa gcgggtaatc ggaacgtacg 1981741 gtttgttcaa gttctctttc gattacatca atatcgtcat ttaaaaaaga gtaggccatt 1981801 ttaaatttca tatcattcac ccaaacatct gtgttttcat ttccatccga tatgcgtggc 1981861 agcgactccg ccagtaaacg aatgatattt aacatttttc aggcccgcct cttcaaacag 1981921 gcctgccagt tccttcattc cagggaaatc tctggctgat tcttgaagcc aagaatattc 1981981 tttatagctc ttcgcaaaca gtttcccgaa aaacggcata atatacttaa agtacataaa 1982041 gtaagcctgt ctgaatccga acatttccgg ctgggacgtt tccagacata ccacctgccc 1982101 gcccggcttc actacacgtc tcatctcttt cagtacagtc aagtaatcag ggacattgcg 1982161 gagtccgaag ccaatggtga cataatcaaa tgtatcatca tcaaaaggaa gctccatcgc 1982221 atttccgtgc agcagttcaa tttggctgaa tccgccgtct tttactttct gctcgccgac 1982281 actcagcata ttttcactga aatccaagcc cttgatctcg ccgcttttgc ctgccgcttt 1982341 tgcaagagcg atcgtccagt cagccgttcc gcagcagaca tcaagtgctt ttgcgccttc 1982401 ctttacattc atgatgcgca tcgttttgtc gcgccatttt ttatgctgct gaaaactgat 1982461 gacagagttc atttggtcat aatttttata tattttttca aatactccgt gtacgcgctg 1982521 ttcttttgag tcctgcataa tggtttaccc ttcttccact ttctgatgat aggtttgatc 1982581 ttggctgatt gtcttcagac ggtttattaa aatgttctga ataggtgaat ttagaggcag 1982641 aagtgactca atgctgtttt tcgctttttt aaaacaatct tctaatatct cttcttttgt 1982701 ttttcccagc tgtataaaac tgccgatcac atccagaaat gcatcatttc cgttcataag 1982761 ccgcttaaat acaaaaaaat cactcgacag ctttttccag cgcgggaggt tgaagtgttc 1982821 cgccacacga tggaataaag ctgattcaac gatgccgaca ctttcgaaaa aatcgttttc 1982881 gtccttgaaa gaacggtcat acagacgaat tttatgttcg ttgatttctt taatggctgt 1982941 agcaagcgtc cgaatcatgt agatatcctt catttcagat agtaaagagt agtacagccc 1983001 gctgaaataa tcgcccgcga gaacagtcaa ttggcggttt ttgttttcgt ctcgttttat 1983061 gactctagct gtcgtcactt catcatgggt atcaagggcg ctttgtacaa gcatcgctgt 1983121 tacaatataa ttttctctgt cgttgttttt tatgtcggct tcttcaaata aagcatgaaa 1983181 aagaagaagc ttatcctcat caattttcgg cgcagaaata tgcttcgcta aataaggatg 1983241 agacagcttt tgttttaatt tcgtgttcag attggctaaa gttccgtaga tgtcttgcaa 1983301 aaatatcacc cttgtcccca aattcacatt tatttcttaa tctatgtatg agttttatct 1983361 tttcattcgc ttacgcaggt atcattatag cataaaaaaa agaaattggc tgtatcctcc 1983421 cgctgtttgc gagcatttgc ttttaacagc ggggacagcc agcttatttt ttttcgcttt 1983481 tcatttctcc gtacgcggtt tgaatcagtg cctctcctct gactttaatg gcagaagtat 1983541 gctctgtaaa ctgagcgatg atcacttctc ccttgtcgag tttttcggaa tggtgaaact 1983601 ttgtgtctgt tcctcttgtc aggccgatca cattcactcc gtcctcaacg gctttaatga 1983661 cgacaaaatc acttgaatgc ttttggttca tttatagcac cctctatctt tattagtcct 1983721 ggcgtttaat atgttccaat acttctgcac gggcagcggc atcatcttta aaaacgcctc 1983781 tgactgctga agtcacagtt ttcgcacccg gttttcttac accgcgcatc gtcatgcaca 1983841 tgtgttccgc ttcaaccact accattacgc catgcggatc aagcgtttct acgatgcttt 1983901 ctgcaattgt agaagtgatg cgttcctgaa gctgcgggcg ctttgcaacg gcttcaacgg 1983961 cacgtgccag tttgctgagt cctgtgacct ttccgcctcg cgggatatat gcaacatgtg 1984021 cttttccata aaagggaaca aggtgatgct cacacataga atgaaacgct atatctttta 1984081 caagaacaag ctcctcatgg ttttcaccga agatagtctg gaaatgttct tttggatctt 1984141 cattcaagcc ggagaatact tcggcataca tctttgcgac tcttttcgga gtatcaagaa 1984201 gcccttctct attcgggtct tctccgatcg cttctaaaat ttgacgaaca gcttgttcga 1984261 tttgctcttt attaacttct ttcatgttct atgtcctcca ccaatgaata catttaattt 1984321 cgattctagc acatatgccc cgctaaaagc aaagtgaatg ccctgtcagg aagcccatgc 1984381 tcttgaaata tgaaaagccc cttagaaagg ggcttttctg tgaagaaata aagtgtatgt 1984441 aagctagatg catacacgat ctatattcac aattattttc cggcaactgc gtctttaagc 1984501 gctttacctg gtttgaaagc aggtactttg cttgctggaa tttcgatttc ttcacctgtt 1984561 tgaggattgc gtcctttacg tgcagaacgt tcacgcacct cgaagttacc aaaaccgatc 1984621 agttggattt tatcaccgtt tttaagtgca tctaagatcg tatcaaaaac agagtcaact 1984681 gcttttgtag cgtctttttt agacaattcg cttgcttctg caaccgcatt gataagttct 1984741 gttttgttca tgcctttcac ctcctcccaa aaggatacat tcagttcgtt tattatcatt 1984801 tcttcacagt tcagtctgat tctaaacctg tctcagaaaa aaatgagagc aagtaagaga 1984861 aagacaatta aacggctttt taagaaaaac tgcactctga ggaatgtttg tccaacaaag 1984921 tgaagaattt ctgtatgtag agtaacacat ataaaaagcc atatcaagca ttttaaagcg 1984981 tcaatccctt gctcgtcaag gatttaaggt gatttaccga acgaatattc ctttttttcc 1985041 ttttttcatc ctattccttg atccttttcc attattaaga gcaaagaaaa aagacctccc 1985101 attctataaa gaggtctacc ggtattacag gatgatggcg attaagccgc cagagccttc 1985161 gtttatgatt ctttctaatg tttcttttaa tttataccgt gcgttttcag gcatcaatga 1985221 cagctttgcc tgaatccctt ctctcacaat tgagctcagc gaccttccga agatatcgga 1985281 attccagatg gagagcggat catcctcaaa gtcctgcatt aaatagcgta caagctcttc 1985341 actttgtttt tccgttccga taatcggggc gaattcgctt tcgacatcta ctttgatcat 1985401 atggatcgac ggagcgacag ctttcagcct cacaccgaat cgcgagccct gccttataat 1985461 ttccggctca tcgagactca tatcagctaa agcaggcgct gcaatgccgt atcccgtctg 1985521 tttgaccatt tttaaggcat cagacacttg atcatattct gttttcgcat gggcgaagtc 1985581 ttgcatgagc tcaagcagat ggtctcttcc tctgatttcg acgcccacaa cttcttttag 1985641 gatttgatca tatagatgat caggcgcgta caaatcaatt tctgccaccc cttggcccag 1985701 ctcaattccg gctaatccgg cactttcaat gaattcaaac tcgctgaatt ggccgacaac 1985761 cctgtctacg tcccggagcc gtttaatatc cttaaccgtt tccttcacgg actcctgata 1985821 gctttcacgc aaccaatggt tttctttcag caccattacc cagcttggga gattgacatt 1985881 cacttctagc accggaaact cgtagagggc ctctctgagc acactcagca catctgattc 1985941 ccgcatgctc tctacactca ttgccaatac cgggatatca tatttttcgc ttaaatcctg 1986001 gcgcatggct tccgtttccg ggtgatacgg cctgactgag ttgatgacca taataaaagg 1986061 tttgccaacc tctttcagct cttcaatgac tctttcttca gcctctatat agtcacttct 1986121 ggcgatatct ccaatggtgc cgtctgtcgt aatgacaact ccgatggtcg agtgttcttg 1986181 aatgactttt cgtgtgccga tttcagcagc ctcatgaaat gggatcggtt cttcgtacca 1986241 aggcgtattg atcatccgcg gcccgttttc atcttcatat cctttagcgc cgggcactgt 1986301 gtaacctaca caatctacta atcttatatt cacatcgagt ccgtctgaca catgaacaga 1986361 catcgcctga ttcggaacaa atttaggctc tgtagtcata atggttttgc cggctgcgct 1986421 ctgcggcagt tcatcctgcg ctcgggcccg gtctgcttcg ttactgatat tcgggagcac 1986481 cacaagctcc ataaattttt taatgaacgt ggattttcct gtacggacag cacctacgac 1986541 tcctaagtat atatcgcctc ctgttcgttc agcgatatcc ttgaaaatat cgaccttttc 1986601 caagtgatcc cctcccggac ttcctatcct tttcaatttt attaagctct ttcaatcaaa 1986661 cacaggacac tatatgtgta tgacgttgtc ctatttgaat atgacatctt tagaaaattt 1986721 ctcatcctca atctattaat ataaaaaaac ctttctccct atttgtatgc aagggagaaa 1986781 ggttcattcc tttttcatat cattttctaa aaaaacaggt tcctgtttgt catttaccgt 1986841 atattttaca gaaaacgcgg ggacaaaggg ggtttcatgc caaatcatat cctggatttc 1986901 agtcccgggt ttaaacgttt ttttgctttt tttgaggcaa gaagccagct cagtccggta 1986961 atcggcatat atttctccgt ctccgtcaat cataagcggc aaggaattcc ctgagattgg 1987021 gcttgtcact gtaagagagc tgccatcccc aagcttcttc tcatcgagtg taaataaatc 1987081 acgagatagc acatccttgt aaggcggata ttgatgctcc tgacgataca tttggatgcg 1987141 caatttcaca tcgcgaattt tttctgccat ctttagatca attaatttaa cagtcggatc 1987201 gttctctacg tcaacaagca cgtattgata gtctcccccg ctttcaaatg ccgtacttgg 1987261 aggttcagct atgtatcttg gcgctaaccg gttaaagtct atcggatatt tttgatatag 1987321 cggtgtcgac atatctttgg tttgaatagg aagcagccct ccatttgcct tttgaaattc 1987381 atcaacagca gattgaacct gctttagctg gtcttgataa ggaatggcat gcacactgct 1987441 tttccgttca tttggatata aacatccgga taaaaacacg actgccgcaa aaatgattgc 1987501 gcacttcagt ttacccatac agcacttcct tttacagctt tattcattga cagggccgct 1987561 aaaaaccacg acaaacacaa taattccaga tatgagcata cacatgtatg cgaatgatga 1987621 aatcgcaatc ttcaaaaaac ggttttggca cttaaagcgg cttaaataga tggaagctac 1987681 agccagaaac atcagaccca tggaccctag agcaaaccac attttcatca atgccagatt 1987741 caatgacgtg cgcctccccg atatgtaaga tataagcgtt atattatatt ttaatataca 1987801 gcgccggaaa agatcaacca gattttccat ccattgatag aacaaaaaaa ctgaagcaaa 1987861 gagggggacc ttcgcttcag tcaacttgac tatattcacc tgcacgttta agaaacactc 1987921 tcttggactt cgatgctata gtatgcgact tggcatacag atgcatcctc tattgcctaa 1987981 atcggcaaaa tgtttcagga gatcccaaga cttgggtgtt cttctgtttt tcgggctttc 1988041 gttcaattaa gatatgcgat tcaccatttg attgacactt ttacttcact tgattttcaa 1988101 acgtatttac caaatcctcc atctcgtggg ttttccctct cgccattaaa gattcaacag 1988161 cggtttccac tttttgtccg ttgaatagga cctgatggag agcttctgta atcggcattt 1988221 taacatcata tttcttcgaa agctgataag ccgctttcgt cgtgcggacg ccttcgacta 1988281 ccattcccat ctcttcaaga acatcttcaa gcttgtaccc ttttccgagc aaattgcccg 1988341 cacgccagtt tctggaatga acacttgtgc acgtcacaat cagatcgcct actcctgtca 1988401 atccagagaa cgtcaaggga tttccgccca ttttcgttcc gagtctcgcg atttcggcaa 1988461 gtccgcgtgt aatcaaagca gctttggcat tgtcaccgta ccctaaacca tctgtaattc 1988521 ctgcagcaag ggcaataata ttttttaaag cccctccgat ttcaactccg ataatgtcag 1988581 gatttgtgta cacccgaaaa ttgtgattaa taaatagatc ctgcacctct tctgctgccc 1988641 tcatgctctt tgaagatgca gtaacagttg tggggtgccg cagccctact tcttccgcat 1988701 gactcgggcc ggaaaggaca acgatatctt ttctgacatc actcgggagc tcaatttcca 1988761 taatttcaga aatgcgcaga agtgaatctg gctcaatacc cttgctgaca tgaacaaaga 1988821 ctgccttttt cgttataaaa gggacagcct gtctcagcac ttcccgaatt gcttttgtcg 1988881 ggaccgcaac gataatgaca tctgcgtctg aaacagcctc tttcatatct gttgttcctt 1988941 taatggatgt agacagctta acattcggca aataatcttt gttttcatgc aactcattaa 1989001 tttgatgaat taaatctgca cggtgagccc acacacacac ttcatttcca ttatcagtta 1989061 gaactaaagc cagtgctgtt ccccaactcc ccgctccaag cattgtgact tttttcatgt 1989121 ttgattcaca cctttttatt ttctagctct tgcaaatatt ttgattggtg tcccctcaaa 1989181 accgaacgcg tctctgattc ggttttctaa aaaccgttcg tatgaaaaat gcatcagttc 1989241 cggatcgttt acaaacacaa cgaagcttgg cggctttacc gacacttgag tcgcatagta 1989301 aattttcaaa cgagaaccgt tatgagtcgg tgtcggattc attgccacag cgtccatgat 1989361 gacatcattt aagacgtttg tttgaactcg aagtgaatga ttttcactag ctttgataat 1989421 cgcaggcatc agagtatgga tccgtttttt cgttaaggca gacataaata ggattggcgc 1989481 ataatccaga aattgaaaat gatcgcgaat attttcttca aattctttca tcgtgctctc 1989541 atctttgtca acagcatccc atttgtttac gacgatgacg acggccttgc ccgcttcgtg 1989601 tgcataaccg gcgatacgct tgtcctgttc aataatgcct tcttcgccat ccagcacaac 1989661 cgccacgact tctgagcggt caatcgcttt tagcgcccgc agtacactat acttctcagt 1989721 cgtttcatag actttccctt tttttcgcat acctgcagta tcgacaatga caaactcctg 1989781 ctggttgtaa gtaaatgacg tatcaacagc atctcttgtc gttccagcca cgttgctgac 1989841 aataacgcgt tcttcgccga gcatcgcatt cacaagtgaa gactttccga catttggacg 1989901 tccgatcaga cagaattgaa taacttcttc attgtatttc gtttcaggaa tgtttttaaa 1989961 atgctctgca acggcatcca gtaaatcacc cagtccgagt ccgtgtgttc ccgaaattgg 1990021 atacggctcg ccaaagccta gcgaataaaa atcataaata ttcgctctca tttctgtgtt 1990081 atccagttta ttaaccgcta aaacaacagg cttttttgtg cggtacaaaa ttttcgccac 1990141 ttcttcatca gcagctgtca cgccttcacg gccgttcacc ataaaaataa tcacgtccgc 1990201 ttcatccatg gcgatttcag cttgctggcg aatctgcgct aaaaacggct catcaccgat 1990261 atcaataccg cccgtatcaa tcaaattaaa atcataattc agccattcag ccgagctgta 1990321 tatccgatcc cttgtcacgc caggggtatc ttctactatt gaaattcttt ctcccgcaat 1990381 ccggttaaag attgtggatt ttcctacatt tggtctcccg acaatggcta cgacaggttt 1990441 acccatagta cccttccttt caatccagcc gctttcattt ttacataaat tttcaaccgg 1990501 ttattaaaat catttcattc acttttatga aaagaaaccc ttcagaggaa gggcttaact 1990561 catttattat atcagttttt actgggatca caactattct taaaaatgtt tcacgatcaa 1990621 atacacgtca tctccgattc tgtgagctat tccatcaagg atcgcctcaa gatttttagc 1990681 gaaaagctcc atctcctttt ggtcattgca aaaaaagaca ggtgctcccc ctgcaacccg 1990741 atttcgattt gtcgtgatta cagacaaaat cactttcgta agagattcac tcatcctatc 1990801 accttatcct gattcttgat aaattcagtc ggcattctaa tcgcattttc cagggttgga 1990861 acattgctaa taatttgaac agccgtttcg ggatggtgaa tttgcgggag aacaaatact 1990921 gccactctcc catcatttaa atcccgtttt gcaattggtg tcaaagatgg ctctcctgaa 1990981 tcccgataaa ccccgagcac attggaaaca tcaaataaaa tggcctgacg ctgccctaaa 1991041 tttgctatcg tcgctgctga attaaagttt ttcggcgtca aaataaagcc catgccatgc 1991101 tttaaaatca gttcctgttt ctctggaagc ccgatattca tcatataaat attatcaaca 1991161 aacagtcccg gaccgtcaaa gcgcggcttt atgtactcga tatctacaat atccttcaac 1991221 acactgcccg acataaactt catggccagt aaaaaacaaa cgacagccgc tatgactgca 1991281 gcccagatgg ataaaaacac atacgcagag gttgtcaaaa gcgctgtaaa gatcacaata 1991341 taatttctgc tttcaaacgc aatggcaatc ccctcaatat atgtgcttcc ccttgagaca 1991401 agttcatacg aatccatttg cgtcaatgtg ttccgctcca tgtttcggac atctctaaat 1991461 tgcgtcgctg ccaatgttaa aaatgtgatg gccgtaaatt cctcctgcaa aagcgccggc 1991521 ataataattg cacctaaacc agccgctatc aaccccagtg cgatgtgaat cactttccca 1991581 tgaacatagg tcggatactg gcggtaatcc gttttcagca tataaagcct tgtcgcaatt 1991641 ccggcaatga ccccagcaat aatcggatag atgtaatcac tcatgacatt ttggtagctc 1991701 ctttgtttga tcttttgctt ttctgaccaa tctggcttgc gaggtgttcg tatttagata 1991761 tgccaaacag caatatcatc cccgcagaac acgcattcag ccattgaaag ccgccgacag 1991821 ccatagcccc ggccaacttc tggatcacaa atgaatacac cagttcgcct tggcacatcc 1991881 ctaggacaaa taagacaagc tgcttctcaa aattcctttc aacagaagct gttaaaagca 1991941 ctattaatat aacagcagcc cactcaggtt ttatgatgaa ccaaaccggg tcatataatg 1992001 caaaaagata aacaaacgca tacgcggcaa caagcgtcag atagaccatg atgtaacgaa 1992061 aacgatacat tcccaaatac ccggcataga cacatccgca aacgaaaaac atcaaatatg 1992121 cagcattcag ggaaaaatat aaagcgatgt catgtatgct tagaataata ttagttaaaa 1992181 taaagacaga gacggcaatt cgtcttttcg tcttttcaaa aataaatgtt gtcagaaccc 1992241 acagaaacca cattgaccaa tagtaataaa attgttccat tttacttcct ccatattccc 1992301 agtatggagt tcaagcacat tttttaaaca atcgatctca cattaaggag tatgatcatg 1992361 ggaaaagaca gacaagagaa aaaactcaaa gcttcaggca gagtcgaatc agatcgcgac 1992421 cagtccattc actatgacgg agcgacaagc cttgaacaaa acggaagatt caaaaagcga 1992481 aaatcataat acaaaaagcc caaaccacat atggttttgg gcttttatca tttatcgcac 1992541 actatagctt gatgtattga cccctctctc tgtgagccaa tgatgggttt cacctttgat 1992601 cacaaggggc gccttttgta aatcggcaat tgttctggca cccagcacgg tcataatcaa 1992661 ctttaattcc tcaaggatca gctgaatctc ctcaagcagt ccttcctcac cgctgtcagt 1992721 cagcgctttt aaaaaatgcc ctgccattcc ggtgcaagag gcccccagcg caattgcctt 1992781 tgccacgtca agcgcatctt gcagaccgcc agaggcgatc atggtgcttg caggaaactc 1992841 agagcggatt tccgccaaac ttgcagctgt cgaaatgccc cacgaattaa aaaaggagat 1992901 ttgccgctgt cttcggagat tttcgatttt cgagaaattt gttcccccgt aaccgccaat 1992961 gtcaacagct gcagcaccag cttcatacag ctttcctgct gatgctttgc tcataccgaa 1993021 gccgacttct ttcacaatga ccggtacact gacccggctg caaatttgtt caatgcgttt 1993081 caatgcgccg ctaaagcttc tgtccccttc aggcatcaca atttcctgaa tcacattgag 1993141 gtggatctgc agtgcgtttg ctccaatcat ctcaacggct tcctttgcct gagcagccgt 1993201 tgcctcgctt cccaggttgg caaaaatcag cccgtttggg ttttcctttc gaacaatttc 1993261 ataggaaaga cgctctgatg gatcttttaa tgctgacatt tgcgatccca cagcaagggg 1993321 aattccagcc tgagaagccg ctcgcgcaag cgatttatta atctcatatg taagttttcc 1993381 gccgccgcca gtcattgcat tgataaaaat cggcgaactg cttgaaagtt cgccgatttt 1993441 tgtggaaata tctacttgtt ctaatgcaag atcgggcaga ctgacgtgaa caaacgtaat 1993501 atcatcaaga cctgtttccc gcttctggcc gatggacaag gcatgattga tgtgttgtct 1993561 ttttcgttct gctcgagtca cgtttatcac caattatttt agtttattca gcttatctcc 1993621 gatcagatct ccaagctgga agccagtgct tgtttcttcc ttcgcttgat attgacggta 1993681 atcttcctgg tcagctttag gcgtttcttc aagttcacgc atgcttaatg aaatgcgctc 1993741 ctcattttca ttcacatcaa gaaccttcac ttttacagtc tgtccttctt caaggacttc 1993801 atgcggcgtg ccgatgtgtt tattggaaat ttgagaaata tgaacgagac cttcaacacc 1993861 tggaaggatt tcaacaaagg caccgaagct tacaagacgc tgtacagttc cttcaagcac 1993921 atcgccaggc ttcacttttt cgccgatttg gttccaaggt ccaggcagtg tatctttgat 1993981 cgataaagaa atacgttcat tatcacggtc aaccgataac actttcactt ttacttcttg 1994041 tccctcttca acaacgtcag acggcttctc tacatgagag tgggaaagct gtgaaatgtg 1994101 tacaagtccg tcgatgccgc caatatcaac aaacgcgcca aagtcagtca ggcgctgtac 1994161 tttgccatca agtacacttc caacttcaag agactgaaga agttcttgtt ttttattcgc 1994221 ttgttcactt tcaacaacag cacggtgtga aaggatcacg cggtttttat cacggtcaag 1994281 ctctacaacg agcagtgaca gtgtttttcc tttatagtca gtgaagtctt caacgaaatg 1994341 tgcttcaaca agtgatgccg gaataaaacc gcgaacgccg atatcaacga caaggccgcc 1994401 tttcacgaca tctttcactt cagcttcaaa cacttctttt gtttcaaatt ttttctcaag 1994461 gtcttcccaa gcgcggtctg catcaacagc acgtttagat aaaatcaaag catcgtcttc 1994521 cacttttgtt actttcaggt caagctcgtc gtctacttta acaacatccg atgctttctc 1994581 tacatgaaga cttgataatt cactgattgg aataataccg gattgtttga cattgataat 1994641 ttctacatct acatgtttgt cttctacctt tgtcacaatc cctttaacta catctccaac 1994701 ctctggcact tgaacatcaa tttgattcat ttcctctgtc atttgaataa cctccttggt 1994761 ccaaacctac acagcttaat taaaacggtt tgaaagctga acatataaca tgcccgcttt 1994821 tagccgaata tgtattaaag aatcatccaa aaaagttttt tgaatgatca ataaaaagtt 1994881 ttattagtat taacttctaa taaaaggaca ggtttgtcaa gcaataacat tctatcttcg 1994941 ttgaaaaatt caaaaaaagt ggcatttgcc atcctcagcg ggacttttgc tccacagcct 1995001 cgaggatttt atcagctacc tcttgaatgg aaagcgatgt cgtgtcgatt tcaagagcgt 1995061 cttctgcttt acgcagcgga gatacttcgc gctctgaatc aagcttgtct cttcttgcaa 1995121 tttcctcaat taatgtttcg tagttgacat caaagccttt tttcacattt tcttcataac 1995181 ggcgtttcgc tctctcttcc acagatgcca aaagaaagat ttttacttct gcatttggca 1995241 gcacatgcgt cccgatgtca cgaccatcca tgacgacgcc gcctttttcc ccaagctgct 1995301 gctggcgttt caccatttct tctctgacac ttctgtgctt ggccgcaatt gaaacttggt 1995361 tgctgatttc atctgttctg atcgcctcag ttacatcggt gccgtttaca aacacttttt 1995421 gtccatcttt tgttgtaatc agctcaatgt ctgtccgctt tagcagctca gccagttttt 1995481 cttcatctgt cagatcaacg ttttcctgta aagccgcgta cgtaatcgcc cgatacatcg 1995541 ctcctgtatc aatatatatg tacgattttt tctcagccac aattttggca acggtgcttt 1995601 tccccgcagc tgccgggccg tcgattgcaa tcgataattt cttttccata attcctctcc 1995661 ttgctctttt ctcctctaag gattgtatca cgaactttat gaaaaagggt gaaaaattga 1995721 tgaataatta atgtttgaag gtttcaatcc tattgttttc ctccatttta tccacccctt 1995781 catattgaat cacttttgat acgtatggtt caatatgctg atagtgaaaa agaaattgga 1995841 caccaagtaa aatgatggcc tgaatgaaca ataatttgat cagcagccgt tcaaatgttt 1995901 tcattggagc acctccatta caaatagtat ggaagtgttt gccgatgttt attccattcg 1995961 ggcctttctt ctcttattta actggcgcct gatgcagtat tgaagcaaag cctgctggtc 1996021 acctgctgca atttctgaat actctaaagt catttttcgt ttttctgact tggggtcatt 1996081 aaagattcgt ctgacaactg cttctgtttc tatttgacgt gtgtgctcct cttcaggaag 1996141 acggatgatc aggcgcaatg attcccccga ttgaaaagaa aggccatcag ctaaaaccac 1996201 ggcgatgccg cctgcactga tgttatagga tagtgtgcgg atctcttctt catttcccgg 1996261 ctgaatttgc acatctaata ccgcatcagt tcttacatat tggcggcgct ggattctttt 1996321 cattttttca cggggaggca tttcaagaca gatcatttga agtttgtcct tcactttacc 1996381 ttttatacgg cttataaagc gataaggaac ttcgtctttt cccacaaact ctaccgttac 1996441 ttccatatcg ttatgtaaaa tcacagttcg ccctgtaact acatcaacag gatacgcgat 1996501 caaaagttca ttgttttcga tgctgaccgc cttgcttttt gcctttttca attcattttc 1996561 ttctatatat tctaaaagta cattttctcc aatctctatc attgacttca ctctttcgca 1996621 ttcaatatac tcacgttttt attaaagcac gtaatgaaaa aaaggaaaag acatttagtc 1996681 ctttcctcct gtttttatag gtctttatat ataggttctg cattttttag tttttcaacc 1996741 ttttcttccg atccgtcttt ggcattgata tacattctga atgtgtcatt ttcaattgtc 1996801 ccaagcattt cgtagcataa cacttcttga cctagttcat ttgtaatcaa agcgagcctt 1996861 gtttctctca cttgtacatt tttatttaat ttagactttg cctctgcttc agtaattgca 1996921 ggcttaggta tggttctttt tctgtgagat gtgaggaagt ctcttgctga aaagccgaca 1996981 acctcaccgt catccaaggc cactttcata cgaattgcct cggggtacat ccggacttta 1997041 ttttcaacag gaacatatga aaatacaccg attttatcat attgggcact ttcatcaatt 1997101 tccaaatcat ctgtttcaaa tccgtttttc tttaaaaatg caagcgctcg gttcgatccg 1997161 tcatttaaac tgattttctg atctttcact tctctgtttt ggatcaagta taccggatgc 1997221 ccgcccttct tcgtaatatc catataaatc actgctttat ggtctgggtc tttcatgctg 1997281 atgctatata catcgcgatt tgtttttttt ccgctcttta ccactttaat tgaataattg 1997341 tcatctgggg caaagcgctc agcaatttgt tttgcttcct gttcggaaat ttgttttccc 1997401 ttcagatggc tgaagccttt ctcttctttt ttcgtactgg tgaaactcgg gccaagatca 1997461 gtgccagtgg agaatgcacc aacatttttt tcgactgttt taaagctgtt gataatcgta 1997521 ttatcacttt gtttttcgtc agaagccaga gccatttcta cgtccatcca gcgaaggttt 1997581 ttgctcatga caaggtgctg aacatgacgc aattcatttt gtatatcttc ggactgctga 1997641 tatagcttat ttagtgatgt atactcgttt ttatcaagcg gcttttggtc caaatctctg 1997701 actgacgttt tatagctgaa atcgccgatc tttgataata gctcttcagt tttattaaac 1997761 ggcattaatg taagcggcag ctgactgacg ctgttatgag cttctgatgt aatcctccac 1997821 acatcgatca atgcaggcga cagtgatttt tggctgttca tggcaagtgt tgttccgatt 1997881 ttatcatgaa gctgatccac ctgataggta agctcatgaa acgcccgctg atagttattt 1997941 tcagcatgaa gaagaactgc gtctttttcc tggtgttctt tgtatcccca gtagcctgta 1998001 ccgactattg caataccaag cacggcgatt aaaattcctc tgatcattta tcacacctct 1998061 ttttatgctt tctcatatct gctactcaca gaaaatgtgt ttaccgattc ttttaatctg 1998121 cggacgcccc caaatccacg gacttgtagc cgtatccgga ttaaagtagt aaagtgcttc 1998181 ctctgatggg tcccagccat tgatggcatc cagcactgct tctcgtgccg tttcattcgg 1998241 ctgcatgtaa atttgtccgt cggctactgc tgtgaaggca agcggctcaa aaataacccc 1998301 cgctactgaa tttggaaata acgggctgtt caaacggttt aaaatgactg ctgcaatagc 1998361 aacctgcccc tcgtacggct cgccccgggc ttcgccataa accgcttgag caagcagcct 1998421 gatatcgttg ttggaaaatc caccaggcat gttcgctgct accgcatcct gttttcttgc 1998481 ttttgctggt gtattgtttt gctgtttatt cgcattcgct ttaggcttct gcgttgtttt 1998541 ttccgcaggc tgtttctgcc gtgcttctgc ttgttgtctt gccttttgtg ttgctgcttt 1998601 tgatggtttc gtctgatact ttagcggaat ttttccgtaa tgcgtgaatg tattcccttt 1998661 attgagctgt tccatgacat attcacgata gtattttgat ttacatatta aggtttgctt 1998721 tgttttagct cctacaaggc cgtcaacctc ttttaacccg aattgatcct gaaaatttcg 1998781 aactgcccag tacgtccccc atccataaac cccgtcaatt tttccgttat aatatccgtt 1998841 gtattgaaga cgcgcctgaa gctcgaccac atcatcccct gttgcccctc tttgaatgac 1998901 ctgattcgaa aaggcagaga tcgtttcagt attaataaac gtcgttattg taaaggaaaa 1998961 aaggatgaga catgccataa tcgatccttt ggacttcatc ttttcaagcc tcctactgca 1999021 aatttttaag tgtaatcgta ttttctgtaa cgaggttatt tttatacact ctttccttgt 1999081 tatccctcag aacataaaaa ctgcacacaa aaaagccgca cggttgctgt gcggcttcta 1999141 tacttgcatc atattaacgg aacgggcttt tttcgcttta cgcaaaccaa accaccataa 1999201 aaataccata aatggaagca tataataaat ccaattgcta agcgctgtta ggataaaatc 1999261 atatgatcca tgcaaaaggg atgggacaac taaagaaaga gtaagccact ttacacgcgc 1999321 cttatcagcg gaaaaacggg cttttccaag gtaaaatccc attataacgc caatcaaggc 1999381 atggcatgaa acaggcagca gcgccctgac aaacgcatgc tccacgccgt ggccaattaa 1999441 ataaagaata ttttcgaggg ttgcaaaacc gagtgataca cttgcaccgt acacaatccc 1999501 gtcataatgc tcatcaaagt gggcgtgcgg gtaaacactg atcatcagta taaaccattt 1999561 taatgattcc tccaaaaacc ccgaagataa aaaagaaacg aaaaagcttc cgcctcctac 1999621 attctctttt tcaagtacat actggataaa catgatggga aatacaagaa caaccccgag 1999681 aaaaaacgac cgtagcacca tatgtacagg ttcattatca tactgatctt ttaaataaaa 1999741 ataacttaat aacgcgatgc cgggggcaat tcctgcagag atgattgcaa acatcaggca 1999801 acctctttcc tttatattcc tacatctatc ctaccatgtt gtttaaaatt ttacatctgt 1999861 ctgcacttaa aaaaacaaaa agagcatacg aatgcatcat atgctcctca tctttaatgg 1999921 ttttctcttt tggcgatttc cgctgcgata tgccccccgt gaaacctgcc gttttcaata 1999981 aatatttcat ttgcattgtt tcccgcagca ataacaccgg caataaagac accttcaacg 2000041 ttcgtttcca tcgtttcttc gttgaaaaat ggacgccctg tttctttatc aatttcaaca 2000101 ccaatttttt caagaaattg atgatcggga tgatagcctg tcatggcaaa tacaaaatca 2000161 tttttaatgg taatgagttc tttctctccg gagcgaaaca caacttcatt ctcggtgatt 2000221 ttttcgacac aagctccaaa ttccatacgg attgtaccgt ttctgacgag agcttcaaat 2000281 tccggcagaa tccacggctt aatgctcgga gaatactcat tgcccctata taaaactgtg 2000341 acacgcgccc cagatttcac gagttcaagg gcggcgtcca cgcttgaatt tttcccgccg 2000401 atgacaacaa catctttatc aaaatacggg tggccttctt taaaataatg aaatactttc 2000461 ggcaaatcct caccgggtac gcccatatag tttggatgat cataatagcc tgtggcgatg 2000521 atacaatatg gcgtcgtgta ggtctctttt gacgtctcaa taacgaatgt gttattttgc 2000581 gttttcgtca ctttacgcac catttcaaac gcattaacac ggatgttttt ccgtttaacg 2000641 acttcccggt aatacgataa agcctgaatt ctgacaggct tcctgttctc tgtaataaat 2000701 gccacatctc cgatttcgag cttttcactt gaactgaaaa aggtttgatg cgtcgggtaa 2000761 ttgtaaatac tgttaacgac attgcctttt tcgatgacga gggcatcaat gccaatttgt 2000821 tttaggtgaa tggcagcaga tagtccacaa ggtcctccgc ctataataat tgctttttct 2000881 tgaatcattt ctgtcaactc ctgcgattgg catttcactt catattttct atttccgaat 2000941 aaaaaaatct cctattttat cataggagat tttttatttt tatgcaaatc atcaacttat 2001001 atccagcctc taaaacgcga agcttcagcc attttgcgaa cgccgaccat atatgcagcg 2001061 agcctcatgt caattcttcg gttgttagcc atttcgtaaa tattgttaaa tgatttgacc 2001121 atcatttttt ctaatttttc ttctacctct tcttcactcc agtagaagcc ttggttattc 2001181 tgaacccatt caaaataaga aactgttacg ccaccggcac ttgccagcac gtctggtaca 2001241 agcagaatgt cccggtctga aagaattttt gttccttcaa gcgttgttgg tccgttcgct 2001301 gcttcaacga caattttagc ccggatatta tgggcatttt cttctgtaat ttgattttca 2001361 atcgcagcag gaacgagaat atcacaatcc agctccagca gctcttggtt ggtaatggta 2001421 tcgttgaaaa gctttgttac ggtaccgaag ctgtcgcgtc ggtcgagtaa ataatcgata 2001481 tcaaggcctt ccggatcata aagtccgcca tacgcatctg agatgccgac aacttttgcc 2001541 cccgcatcat gcataaattt tgccaaatag cttcccgcgt ttccgaagcc ttggacaacg 2001601 acacgcgcac ctttaatatc gatgcctctc ttcttagccg cttctttaat acagatggta 2001661 acaccttttg ctgtcgcaga ttctctcccg tgagatccgc caagcacaag cggtttgcct 2001721 gtaataaatc caggcgaatt aaattcatca attcttgaat actcatccat catccaagcc 2001781 atgatttgtg agtttgtaaa tacatccggt gccggcacgt cttttgtcgg gccgacaatt 2001841 tggctgatcg ctctgacata ccctctgctc agacgctcca gctctctaaa cgacatatcc 2001901 cttggatcac aaacaattcc gcctttacca ccgccatatg gaagatcaat tatgccgcat 2001961 tttaaactca tccaaattga aagcgccttc accgccttca cctctttttc tgttacgttc 2002021 gggtgaaaac gtatcccgcc tttcgttgga ccgacagagt cattgtgctg cgcacgatat 2002081 cctgtgaaaa tctttactga accgtcgtcc atacgaacag gtatttttac cgttaataat 2002141 ctcatcggct cttttaacaa ttcgtatacc tcttcgggat atcccaattt ttccagagcc 2002201 ttatgtatta cggtttgggt tgattttaat acatcaagtt tgtcctcttc tgtatgaccg 2002261 gtgtttcgat cggctgccat ttgagttaac ctcctagaat cttctgtttc tcacatgctc 2002321 cctttcagag aatagtatac accttcatat gatctgtgca tagaataaac gttatgtttt 2002381 tccatgtttt ttaacgaaaa aaaactgctg aaatcagcag ttttccgttg cattcttatg 2002441 aaaaatgagt ttgtatcgtt tctacggcat taccgtccat aatgagctta ccatactctt 2002501 gcaggcgata aatcgttaaa gttgtcggat tgccgtattc agccagaacc gccacaaccc 2002561 cttcagccgt atgtgaccct agatcttcaa ggcttaaaaa gtactgcccg tcatagtggt 2002621 agacagttcc ccctgtgata ccgattcgct gtaagctttc tgaaagctga atgatatctt 2002681 caaaggaatg gaattgatat atgatgtccg cgctttcatc aagcttgact tgcatttcga 2002741 tgtaatcatc atcatactca tcgtcttctg aatcggcgtc ttggttcttt gttacaatca 2002801 cgaccatccc ttgtgcttgg agagaataca cttccactgc aatcggtcca ttcgcttcaa 2002861 agccgagctc tgtatttgct tcattcatca tatctttaaa taactggtgg actttaaatg 2002921 agtccttcca gaggtcttct tttgtcaatc cccggtctgt caaatcatcg agggttaaaa 2002981 agattttgat cttattataa ttcagacgct caagccgcat aacgttccct cctgcctcta 2003041 cttgcacaca aatcatataa cacattatat gagatgatga gtcataggtt cttaattgtt 2003101 atcagtttac actgagttca ctagtaagac aagcacaatg cagtttttat tgccatacgg 2003161 atttttgctt tttagaagtt attctggccc gcaaagagtc acaatgtgag tttcaggctc 2003221 agcacctaaa cgaagaggca cttttgtcgt gccgtagccg ttgctgatca gatatgccgc 2003281 gtttttaaca atacctgttt tccccagttc ataaggaccg aattttccaa acctgatctg 2003341 gcctccatgg gtatgtccgc tgagtatcac atcaataccg tcatcttcat tgatttgttc 2003401 atgaatctcc ggattatggc aaaccagaat attcagctgg ctttcatcaa gttctttgat 2003461 ggcttcctca taatgatcca tctccatcct gatatcatca acccccgcaa tcgcaatcgt 2003521 atgcccattg tatgaaaacg ggactgactc atttctcaga gtgatgacgc cgtgcgcttt 2003581 aaatatggaa tacagcttat gctgcctgac ttcataatca ttattccccc acacaaacac 2003641 gatagggacc ccgaaatgta cgagcctttt gatgttttcc tcgattctcg cactgggcac 2003701 cccgccctca gctaaatcac cgccgattat aaccaagtgg ggggcatggc ttcgcgcttt 2003761 ttctaaaagg tcttgatcga tgagacgttt gtgaatgtct gaaataaaaa agattgtcag 2003821 aggcggcttg cccttcatct ttgataaagg aaacgtatgt gtcttcaaat gattgccttt 2003881 tgctgttgca tacatttttg ccgtcattgc cgctgccgca acagttagta caccggcaat 2003941 tttcactgat agcttcataa aaaactctcc attcttttta gaacttatca ataagacgga 2004001 caataaaaaa agacgtttct atcgtttgag aaaacgcccc attttattta ctttcaaaat 2004061 atagattaat gtcatatttg tgcttcatca tatgaaaaac agactctctc gccttccatt 2004121 tatcgggctg cggccagaga tcagtgcttt tctgaataat ttcacatctc agtttatgga 2004181 aatcagtctc ggatttttct tcctttttct tgaaataata tgaagtgcag taggcaaaag 2004241 cggttgccag catccaaaat aaataaaagg tatggctaag tatttcttga agtataagct 2004301 gaggctccgg gcttttgatc atgatcataa cacataataa gcctaggcag ataagtgaag 2004361 cccatcgcca tctgcggcat tgtgctgcat aattttcgaa tttttgtttt cgttttacca 2004421 gcgcttggag catctgtttg gtcggcgcgt ctgtaaactg atccagctga ttccataagg 2004481 attccatacg cttcacacct tgtccatttt cattgctaca atatatgaac gtaaaataaa 2004541 aataataccc tattcatcca ttaaagggat gtccaaaact tgtccggtgt aaacatcatt 2004601 tccattcaga tgattatatg ctcgaatttt ttcttctcct gtccggcttt tataatactt 2004661 catggaaatg cggtatagcg tttctttctt ttggacggtg tgcttgacaa cgcgattcgg 2004721 cacattttga actggctcag ctggctgttc ttgctgttgt actgttgatt gggaagagga 2004781 agcagccgcg gcggttgctt cctccttatt tggcgagtct tctttttccg ctacagcagt 2004841 ctgtttctta tcagcagctg tttgctcttt tggcttggaa tcttctggct ctttttttga 2004901 ctccttctgc agtgcggttt ctttagtgtc tgcggtatcg tttttatcct ctgatttcgg 2004961 gacaacctca tatttgcttt ggctgctgtc aataaaaaca tcttcataat cgtcatgatt 2005021 atccgggtgg ctctttagat aaaataaggt gactaaaacg ataaccggca caaatacaaa 2005081 tattactgcg agtactgtga ataatggcgt ttttgttttg ccttgctttt ttttctgttc 2005141 tctttgattt tttacagatt gtcttgtcgg aaggctttct ccatcatcga cataatcgtc 2005201 cgccaatgcg gcgttttgat cttcataaag attctgggct tttcttctct ctactctcga 2005261 catgttcgtc atgtttatcc ctcctcacat gttcaaaacg aatctgacag gcaaacacgg 2005321 catcaatgat aaaatgcgcc gtcatcggaa caaataagtt gccggtccat tcatacatca 2005381 gaccgagcaa aaagctgatt gctgtcacca taataaataa cagccatttt gacaaatacc 2005441 gaaagtgcag agcggcaaat ataaggctgg ccgtccataa accgatatga gtctgcagca 2005501 ctcctctgaa taacatttct tccgcgaaag caatcagaag cgttaaaaat ataatatgag 2005561 ggattgacct cttactgaat atttttttat tgattccgcc gtcatcatat aaatgagacg 2005621 gaaaccattt cattactgcc atatcggcta aaataacaat aacagctata gaaacaccat 2005681 accagatgat tcgcatatcg cgaatgtccc agagctttaa tacgtcccgt acatcctcaa 2005741 aaaagaacag tcctgctgca gcagcggcaa agatgatgag tagctgcgtc aaatataact 2005801 gcttcagcat atcatggtca gtcatatgct gaatataatc tttttgctgt ttcagttcag 2005861 ctcacctaca gtctgcaagc tgaatatccg gtgcaattcc gaactccagc tgtctaatgg 2005921 cgccatttta ctccgttccc ctttttgttc atacaaggat aaatcaaaac cgcaatgtga 2005981 acagcacggg aggtttccgt catcaggctc gtatgattca tcaaagtagg ttaacagtgc 2006041 ctgccttaaa cagccgtcac gctgaagcaa aaatgataca cggtgcattt tttccagctt 2006101 cagctccatg cgatatgaaa tttctttctt catcagttca actgatgttt ttccctgcat 2006161 aaagagatga atcatcatac gggcctgtgt ctctccgacg ccatactgaa gtaatacgtc 2006221 acgcagcctt ctctcatccc gctcctccgt cttctctagc acacggatta cgtcggcgat 2006281 ttcttcagct gtgacactct ccatctggat aatttgttcc tgcaattcaa aatcccctgg 2006341 cgcccgcagc aaaatgctga cactcggctt tccgtcgcgt cccgctctgc cgatttcctg 2006401 cataaaagct tctgccgtct gcgggagatg aaaatgaatc acatatctga tatcaggttt 2006461 atcgacaccc attccaaacg cattcgtaca acatatcaca tcaagctggt tatgaataaa 2006521 ctgctgctga attaaaatcc tgtcccctga ctccaaaccg ccatggtaaa agtcggctct 2006581 gctgctcgtt ttgcttttaa tttcacccgc taattcctta gcccatttcc gtgttggaca 2006641 ataaacaatt cccggacctt gcaggttttc aaccagctga atgaccctat ctattttttc 2006701 ggcagtatcc gccgcatttt caaccctcag tgcgatgttt gggcggttga ctgagttgag 2006761 atggcgtaca gcatgctgca gctccagcag gttcatgaca tcttgcagcg tttcctttgt 2006821 agccgtggcg gtcaatgcca gaacgggtgg gtgtccaagt ttttttctca gctgtccgag 2006881 ctttgaataa tcaggcctga agtcgtgtcc ccattcagaa atacaatgcg cttcgtcaat 2006941 aacaaatagg ctaatcggaa cgcttttcaa tttttccaat acatatggag actgtaaagc 2007001 ttcaggagac aagtacaaaa atttatatcg atgaatatgt tctaaaacaa attgtctttc 2007061 ctgcctgtta agcatgctgt tcaaagctgc agcacgcttt tccccccggg ctttgagctg 2007121 ctgcacctga tcctccatta aagaaagcag tggagaaacg attaatacca tgccatcaag 2007181 catataacca ggcagctggt agcaaagcga tttccctccc ccagtcggga gcattgcaat 2007241 ggtatccttc ccgctgagta tgctttcaat aatgtcctgc tgcccttttt taaaggaagt 2007301 aaaaccaaaa aactgatata acgtttgctg taatttagtc atattgctgc acctgctttg 2007361 tcaatgccag tctgatttga aagtagctga accgctgttc cagcccgtcg cgaatttgtt 2007421 tgattttatt cgtccgcatc cgtttggcaa actctgcgat ttgaagctgg tcttctgctg 2007481 atacatagtc attaatcata aacgcaggct catggagaga aatctcgaca atgtggtctt 2007541 caatcgtcgc tgttttcagc tttctgattt cagcaattcg ctgtatcgga aacccttgtt 2007601 tgaccatctg ccatgttttc ctcgtcgact ctgtcagggc attatctaag tgcacatcag 2007661 aaaggagatc ctttaacaaa gcatcttcac actccggaag agaatgaata aaataatgta 2007721 ccgaagccca aaacatgata tagacatacc attcgtcttc tttcagcgta tcagcaagct 2007781 gcctgctcgt ataaccgatc cgatggtgcg aggttaagga gtagacaaaa atttgcgctg 2007841 ctttgttttc aatctttttc aaatgcgcct caagcatggc aaaaaggctt tttgccatct 2007901 ctatatgatc cgtatgccgg gacaggtatt tctttaccca gtgaagtgtc ttatgatcct 2007961 ttgtgacagg gatatactgc ctgctccctt gctgtttatg ggataggacc tgcacaagca 2008021 gcgaaagcct tttccaaagc acgccggcag cctgctgata atgagcgccg tgacaatgaa 2008081 cgggccaagg ccgctcgcta agggcatgtc tcaaaactgc tgcgccgctg gctgtcactt 2008141 tgtatgtatc tgattcagac attggcgcga gatatgaatg cttttcaagc ttgtcaagcg 2008201 acgcagaaat atcgcttctc gaacattttg ccgccattcc aaagtatttt gcagtctgaa 2008261 ataagccggc atcttgaatg gtctgtgacg atctcttgcc tttgaatagg tgaaaaacag 2008321 cgcttcccga ccgttccccg tttattttgc aaagacaatc gagaaccata atatcgaagt 2008381 aatttaatga caacctatcc acctacattc ttcctgacaa aaatcgttga tttgctcttt 2008441 ttattttaac agatttcaaa cagaaatcga cgtttaaagt catcattaag ggggatgtta 2008501 tgtagataac cccttatgtg ataagcattc tcaatcattt ttctgttgaa atgtggcagc 2008561 aacatcatta caataagtaa gaggaatagg tgttaaattg attaaatata aagattgatc 2008621 catttgttcc accaagaaca atctgggagg ttttattcat ggcaaagtac acaatcgtag 2008681 acaaagatac atgtattgca tgcggcgctt gcggagctgc tgcaccagac atttacgatt 2008741 acgatgatga aggcatcgcg ttcgtaacgc ttgatgaaaa caaaggtgtt gtcgaagttc 2008801 ctgaggtact ggaagaagat atgattgacg catttgaagg atgccctact gattccatca 2008861 aagtggcgga tgagccattt gaaggcgacc cgcttaaatt tgaatagaag taactaaaaa 2008921 aagctcccga acgggagctt ttttatttaa tggatatgtg cacttcgctg ctgctcaatc 2008981 catggcttaa gcttgataaa aattagtgag aatacaaccg taattacaat accttttatc 2009041 atgttaaacg gcaggatacc tgcgacgact gctgttttta gcgcgctgtc ggataatgcc 2009101 ggtgaatgta aaaaccacgt gtatgccgga agaatcagaa cataatttaa aatactcatt 2009161 aaaatggtca tcgctgcagt tcccaaaagc aggctgacag ccaagccctt tgctgagttg 2009221 agttttttaa ataagaaagc agtcggtaat ataaagagtg ttcctgcaat aaaattcgca 2009281 acttgcccta caggaactcc ggccatgctt ccctgaatga tatactgaag aacatttttt 2009341 atcgcttcta cggcaatacc cgccaaaggt ccgtaaatca gaatggcaat aattgcggga 2009401 acgtcgctaa aatcgatttt taaataatcc ggaagacccg gaaacgggaa atttaacagc 2009461 atcaaaacaa atgcaatgct gctcagcatg ctgaccacaa ctaatttttt tactttcact 2009521 tcattctctc cttttcgatc acatcttact cgaaaacgga aaggttcttt tccagccaat 2009581 aaaaaaaccg cttcatatat aaaagcgggg tttcgaaaat taggctaggc aaagaaacgt 2009641 ttgaaaaatt caatttcaaa acgcttatga acctccatct tctcccatcc agactgtact 2009701 gtcggctccg gaatctcacc gaatcctgct gtaaagacag ctcgcgggct tagagccatt 2009761 ggctcatcac cgccggtagg gaatttcacc ctgccccgaa gattgatcat atgaaattta 2009821 attacattat aaacgataac tggttggctg tatagagaat tgcttcaaat taaatatatt 2009881 acctgcaagc tgtcagatca ttgatttatt aggctttact tttatccttt actgcgtcaa 2009941 tacacgttga cactcttttg agaatatgtt aaattatcag atatttagtt tgtcaattta 2010001 ggaggaaatc taacgatgtt tcgagtattg gtctcagaca aaatgagcaa cgacggttta 2010061 cagccactta ttgaatcaga ctttattgaa atcgttcaaa aaaacgtagc agatgcagaa 2010121 gatgaattac atacttttga tgctcttttg gtgcgaagcg cgacaaaagt aacagaagac 2010181 cttttcaaca aaatgacttc tttaaaaatt gtcggaagag ccggtgtcgg tgtcgataat 2010241 atcgatattg atgaggctac gaaacacggg gtaatcgtga tcaatgctcc gaacggcaac 2010301 accatttcga cagctgagca tacatttgca atgatctctt ctttaatgag acacattccg 2010361 caggctaata tctcagtgaa atccagagag tggaaccgca cagcttatgt cggttcagag 2010421 ctttatggaa aaacgcttgg tattgtagga ttaggccgaa tcggaagtga aattgcacag 2010481 cgtgcgagag cgttcggtat gactgtgcac gtttttgatc ctttcttaac ggaagaaaga 2010541 gcgaaaaaaa tcggcgtaaa cagccgtaca tttgaagaag tgcttgaaag tgcggatatc 2010601 attaccgttc acacgccttt aacaaaagaa acaaaaggct tattgaataa agaaacgatt 2010661 gcaaaaacga aaaaaggcgt tcgcttaatt aactgtgcgc gaggcggaat tatcgatgaa 2010721 gcagcacttc tcgaagcttt ggaaaacggg catgttgcgg gagcagcgct tgacgttttc 2010781 gaagtcgaac cgccagttga caacaaactt gttgatcatc cattagtcat tgccactcct 2010841 cacttgggag catcaacgaa agaagcacag ctcaatgtcg ccgcccaagt gtcagaagaa 2010901 gttctgcagt tcgcaaaagg cctgcctgtc atgtcagcta tcaacctgcc tgccatgaca 2010961 aaagatgaat ttgctaaaat taagccttac catcaaattg caggaaaaat tggcagcctt 2011021 gtatcacagt gcatgaaaga accagtacag gatgttgcca ttcaatatga aggcacaatt 2011081 gctaaacttg aaacatcgtt cattacaaaa gcccttctgt caggcttttt aaaaccgcgc 2011141 gtagactcta ctgttaatga ggtcaatgcc gggggtgtcg caaaagaacg cggcattagc 2011201 ttcagtgaaa aaatttcctc ttctgaatct ggatacgata actgcatcag cgtaaaagtg 2011261 acaggagacc gcagcacctt tactgtaacg gctacgtata ttcctcattt cggagaacga 2011321 attgtcgaga tcaatggatt taatattgat ttttatccga ctggtcactt ggtgtatatc 2011381 cagcatcaag atacaacagg tgtcatcggc cgagtaggac gtattctcgg agataatgat 2011441 attaacattg caactatgca ggttggccgt aaggaaaaag gcggagaagc catcatgatg 2011501 ctttcctttg acagacatct ggaagataaa attgtgaaag aactaacaaa tgtccctgat 2011561 attgtgtctg tgaagctcat tgatctgcca taattaaaaa aactcaagct atatagcttg 2011621 agttttttta ttgttctatc cccgtgtgtt tttatgcaaa atatctaaga cactccttag 2011681 ctcagaaaca ggaatttggc ctggtgcgga cgcctcttct ccagctccaa aagtacaagc 2011741 cgatccaaaa acctcaccgc tcagcctgct gatgagccct gttgcagcca ttgacattgt 2011801 aataatgggg cggtctgcat atattgtttt cattgtatac gtcgcatcaa gcagtgttag 2011861 gagatctcca gtatcattcg gcatgacagc catttttgga atatgcgcgc ctaagtcctg 2011921 catttttcga agtctggaaa taatttcatc ttttacaggt gttttttcaa agtcgtgatt 2011981 tgacatcacc acatagacgt tgttttcttc cgccagcgat actaacgctt ttacatttgc 2012041 atctcctgaa aataattcga tgtctatcag atcgatgtct tttgtttgga ttgccgattc 2012101 cagcaaagca agataggagc tttcgtccat ctccatgctc ccgccctctt tgtgggttct 2012161 gaatgtaaat agaaatagct tgtcttctaa agatttacga agcttagaaa tgagctttgt 2012221 gaccgcttct ctgtcattcg ctttttcaaa tacgtcgact ctccattcaa caatgtccgg 2012281 attcagtaat tttactgcct ctgcttcatt cagaatttgt ttttccgtct ttcccatcag 2012341 cggaatgatg attttcggca tcccttcccc gatggaaact cctttaatcg ttaacacgtt 2012401 cactcgtctc aaatcctttc aatctttacc ttgttttatt atacacgtac aacttttttt 2012461 tgaaaatttc tattatatga atagcaacta aaaaagagcc ttaaagggct ctttttagtt 2012521 taaggaaatc ggatttggag cagctggcac cggaattgca tctgatatgt catatttgcc 2012581 gatttttttc gttctggttt ccgtaaaggt cacttctgtg aagccaaact cttttgcagt 2012641 caaaagtagt ccctcaatca ttaaaatacc ggcaatagaa tcatcaactt ctgactcctt 2012701 tgaaaagcgg atatataagt gtttctgttt cttcgttaca gattggacag cacccgcttg 2012761 aataagaggt gtcgtatctt cttggctgct cgattccatt tccttaatcg cttcttttac 2012821 tgtatcaaaa gaatgatttg acggaacgag aaagtcttgt ccttgtttat tttggtacaa 2012881 gtagtaggat cgttttgact gtttgggaat cgaaatttcc gtaaaagtgc catatgagcc 2012941 aatccgaacc ccagtctcat tttgatccga taaaaatttg actttttcat aaggactcca 2013001 ttttaaggat tctttaagca atttttttaa cagtgtatca tcttttatag aaaatgccgt 2013061 agctggctga tggactcgta tacttaattc cttctgcttt ggtttttcct ttatttctac 2013121 ttcatctatg aaggttggaa ttgtaatggc atgatcaagg atgcccaatt cactactttc 2013181 aaacagcata tcctggatcg tttggtctgc atttgttttt tgaatgctga cgggtatgat 2013241 tgcagatgta tcggcatcag caaccgctac agtgatgtaa ttgtcttgtt ccttttcagg 2013301 aacgacaaac gatgtctgat ccaaggacga tgcagctttt gggctgtctt ctgtctcagt 2013361 tttcgttact gcgttctctt gggacgcttc tttttgttga ggctgtgcct gatcaaagaa 2013421 atgaggagaa ataatgaagg cgatataaac cgcaattgca gcggcacacg cggggccaat 2013481 ccacctgaca gcgggcttat ttttacgctt tgccatcgtc agccgcttgt aaatatcctg 2013541 aggcgaacga tggtctttaa ctgccggaag ttgacttaac aactccttta tctgttcttc 2013601 gttccattct gacttcatca tccattagct cctccctcaa aagctccata tgtttccgaa 2013661 gtactttgag ccctctgtgt tgggtcgttt ttactttgct ttccgagaag cgcagagcct 2013721 tggctgtttc ctgtattgaa tatccctgaa taaaccgcaa gataatcaca gctctttgat 2013781 cgattgtaca ttgatcaagc gcagcataaa tttcccggac attttcatgt tgaaccgcaa 2013841 gttcgtccgg cagcaattgc tgatccctga catcctgtgt atcccagtca aatgtaccga 2013901 gtatacgctg tctgattgtt tgctgtttac ggaaccagtc tatcgcaaca tggcgtgcga 2013961 tagacaaaag ccatgttttt tcactgcttc ttccttcaaa cgtatgataa gaatttaata 2014021 cccggatata aacctcttga agaaggtctt ctgtctggtt tttatccttt accatataaa 2014081 ataaaaattg gtacaaatct tgatgatatg tatcatataa taattgaaag gtttcttcca 2014141 tttgaaaccc ctccgttcac ttttttgtcg tatgaatagc ttgaaaagtt acattacaac 2014201 tatattacga gtaactggaa tttggaaggg aatttatatt aacatatcct taaattttat 2014261 taatgttggc tattaaaaaa acacccgctc agtcagcggg tgtttcttat ggaacaagat 2014321 tcttcggcaa attcagactc gattttaccg ttttgtcgga atataaaaag aaaatgttgt 2014381 tcctttatct attcggctgt gcacagtaat tgatccgttg tgggcttcca cgatattttt 2014441 aacgatagcc agccctaacc cggttcctgc tctgcccctt gtccgcgctt tatctgcctt 2014501 ataaaaccgc tcaaagataa atggcagatc ttcttccggt atgccagacc cggagtcttt 2014561 gatatcaatt ttcaatccat ccttcacaga atggactgaa atggagacac tgccgccggc 2014621 tgaagtatgc cgcagcgcgt tatcaatcaa attggtaaat acctgctcca tcttgtcttc 2014681 atcaaacata aattcctctt ctgtgagaga aatgtcatga tctaaagcaa tatttttttc 2014741 tttcgcaaca ccggaaaact tccgaatgat cttttctaaa aactcattca cattgatttt 2014801 ttcataatgt aagcctgtat ggcctgattc cattcgggct aaatcaagca aatcattaac 2014861 taaacggccc attcggagcg attcgtcata aatgatttgg gcaatttctt tccggtcttc 2014921 ttcagagctt gcaatgtcat cgacaattgc ttcactgtat ccctgaagca tggagatcgg 2014981 tgttctcagc tcatgactga catttgcgat aaagtcctcc cgcagcttat caaggcggcg 2015041 ttcttctgtc atgtcacgca gtacggcaac cgctcctctg acgtgcgatt ccgcataaag 2015101 cggcgacatc aaaagcaccc atgatctgcc ttgaagcgtc atctcaatca tttgttcttt 2015161 ttcagtgctg acagcgtttt gaaacagctc ttttgcttca ggcggaagat tgtcgccttc 2015221 tttgatattc atgttctgtt cataatacca agcctgaaga aaacgttcag ccggcgggtt 2015281 ggtcacaaga atcgtaccgt caatattaat ggtaataacc ccgtcagcca tactgctcaa 2015341 aatgttagaa agctgctctt tttcttgatt gagcgcattg atatgaaagt taagctgccg 2015401 gcccatttga ttaaaagcgg tcgccagttc accgatttca tcctgagtta aaatcgggat 2015461 ttttgtatcg aacttgccct tcgccaaatc ctgcgcgcct tctctcattt ttcggagagg 2015521 gtacgtgacc ctgcttgata aaaagaatgc gaaaaatgtg gtcagcacaa tcgcaattcc 2015581 agcggcaaga aaaatatagc gggtcgtatg ttttgttgta tctttaacgg caagcaaaga 2015641 ctgggataaa aagaccatgc ctttctttcc gtctttttca tacgggacac ctacaatcag 2015701 gcgttcatta tccgtgtctg tatcgctcag tcccgtccgt ttgcttactt ttttatggtc 2015761 tttgagagct ttatttaagt ctttgtcatg ctgtatttgc tcaaccgtaa tagacgacag 2015821 gcgattttta tcattcggag aataccagtg gttcttctca tcctggatga tggcaatgct 2015881 tgttaagtta tcagcgagtt cccaagtgat tgaccttgcc agtgcctggt cctcgtgatt 2015941 ttctaggatg acagcaactt tattcgcaag ctgtgttaaa tcattctcag cttcttccac 2016001 atggtagttt tcaataaact ccagcaaaag aaccgttaaa atgaacaata cgatcaagac 2016061 gagtgaaagg atcgtaaacc acagcttgcc tactacgctt ttccaaaatt tcattcagcg 2016121 ccgacctcaa atttataacc tacaccccat acggtgacaa tttttttcgc agcttccgga 2016181 gataccttgt tcagcttctc tctcaagcgt ttgacgtgag tgtccactgt ccgtaaatca 2016241 ccaaaaaact catattgcca cacttctttc agaagctttt cccgatcata caccttgtca 2016301 ggcgttttcg ctaagaaata tagaagctca tactcttttg gcgtcaggct cacttctgtt 2016361 ccatcagctg ttacgcggtg agcatcatgg tctattgaca gatgtgaaaa cacgagcaca 2016421 tttttcgtcg gtgtattggc attgaaataa gaggtttggg atgctcttct caaaagggcc 2016481 tttacacgca gcacgacttc tctcgggctg aacggcttaa caatataatc atctgttccc 2016541 gcttcaaacc cctgcacccg gtttgcttct tctccttttg cggtcagcat aataatgggt 2016601 gtcgcttttt tttcacgaat ttgccggcac acttcaattc catcagtccc cggcatcatc 2016661 agatcaagca aaattaagtc ataattggct tcaagccctt tggcaatggc ttcatcacca 2016721 ttttcagctt catctatagc ataattttca cgttcaagat acattcttaa aaggcggcga 2016781 attctggctt cgtcatcaac tactaatatt tttgtttcgt tcgtttggtc catgttttcc 2016841 ccctgctttc cttctgttac tttcatttta tcaaatcgtg agaaagtttg agaactgtgt 2016901 cgctttcaaa ggactatgca taagaatgaa gtccggcaag cacaagattt acgaatatta 2016961 aattaaacat aataatagca aaaccgatta cggccagcca tgctgacttc tcaccgtgcc 2017021 agcctcttga cagtcttaaa tgcaagtaag cggcatagaa caaaaatgtg atcagcgccc 2017081 atacttcctt agggtcccag ccccaaaatc tggtccacgc gagctgagcc caaatcattg 2017141 caaagatcag cgcgccgagt gtaaagatcg gaaatccgat tgatacggcc ctgtacccaa 2017201 cctcatccac cagatcaaga ttgacgtttt tcaccagcgg atgtaataga gcgctgattc 2017261 tttttctgat gatcagacgg agagccccat acaacacaag acctgctcca aatgaccaaa 2017321 tgacagtgtt cacttttctg cctgagaaaa gcgcgggaag atcaacaagc ggttccattc 2017381 ttccttcggt caaaagctct ccctgatgcg gaccgacaag cgcgggcatt tcgtacacca 2017441 tcacgctttt ttctttactt ttgtccaccc agttaaactc cgcttcatag cctgcaagac 2017501 gaaatgccga tgtgattgca ataaaggcga cggttgtgac caggataaac ataatcgctt 2017561 caagccagaa ggtctttttg cttggctttg tctggtctac atgcttcaaa agaaagatga 2017621 caccagcgac aaagctgatg gcaagtatag cttgcccaag cgcggccgtt gttacgtgaa 2017681 tatacagcca gttactttgg agcgaaggaa ttaaaggcga gatatctgtc ggaaacatgc 2017741 tggcgtaggc aatcagcaat aaagcaattg acagcgtaaa caggcctaat gaaggcaatc 2017801 tatagagaaa ataaagaatg ataaacgcca aaacaagcat catgccaaaa gcggtggtga 2017861 attcaaacat attgctgaca ggcgcatggc cgcttgcagc ccaccttgtg atgaaatatc 2017921 ctaggtggca gaaaaaaccg acaatagaaa gggtgattcc aatgttggcc catcggtttg 2017981 gcctgccctt tttatcttta ttcccgcgta tggccccgcc gaagattggg acagcgatta 2018041 aatacacaag aaaggccgca taaagaaaat ttccgctcag ctctgccatg acatcactcc 2018101 cttttcgcct atttctgtgt tttgattaat tctttttggt ccaccggttc agtcagtccg 2018161 gaatcagcca atataaatgc taaatccttc ttcaggccaa accagttttt attggtatgc 2018221 cctgctacca taactgcacc gtcctgtgag tgcagccaaa ttcttcgatg ctgccagtac 2018281 ataccttgaa tgacaccgat cataaaaatg gctccgccga cagcaagcac ccagagtgtc 2018341 agatcctttc tgactgtaag tccagtaatg tttttcgttt cgacatggtc aaatttcagc 2018401 ttgtatttat tattgcctga tccttcgatg gtttcttgga tggcgacaaa gctcttttcg 2018461 cctttcggtt tgtccggcgt tatgatatta aagacaaaag ccggattgtt agggatcttt 2018521 gtttttgtgc tcggctctcc gtcctgatta aaatagaagt caggcaggta gctggcgatt 2018581 tccaccttgt aaccgttacc aagatcatag actgaatctg gatccagaag gttgatcttc 2018641 aggctcccaa aggatttttt tgttttttta tcaatcagct ggaacaccat ttggtcaagc 2018701 tgattctctt tgtaatccac ctggtaaacg gaaaaagaat caaaacgcag cggctgattg 2018761 acacggatgt cttcttctgt tactttttcc agcttcggct tctcgccata aacaattttt 2018821 ccttctctct tgtagagtac ggcatcagtt tgaaagttct ttgccactct accgtccccg 2018881 actctgtcaa tggcatctgc aaataccttt ttttccgttt tgctgttata ggtctctacg 2018941 ctgaattgat tgtttttcaa ataatatttt ccgtctgtac ccggaattgc tgcggtttcg 2019001 ccttctctga cccaaagcgt ctcatcgacg tacatgccag gcacaaatct cagcatcgca 2019061 ccaatcagaa agatgatcaa tccaatgtgg ttgacatacg ggccccagcg ggaaaagcgt 2019121 cctttttcag caagaatgct gccctctttt tctctgattc tataatgttt tttctttaat 2019181 agagtaacta tcttttcttt cgattccccg ttcagtacag taactgtttc actgaacaag 2019241 cgctgccttc ttaaaaaggc cgggctcctt ctgacacctt ggttttttaa cgctctatac 2019301 aacggaatga cccgatcaag gctgcaaatc acgagtgaaa tgccgatcga ggcaatgagc 2019361 agcaaatacc accaagaacc atataaatga tgaaacccga gcaaataata aagctggcca 2019421 aacgtgccgt actgctcctt gtaataagta tcagcctgtg cgcccggagg cagataggct 2019481 tcctggggaa aaatggtgcc gaacgctgat gcggcaaggg ttatgacgat aagccatatt 2019541 cccaccttaa ccgaggaaaa gaaattccaa attttgtcga tgatcgtttt gttataggtt 2019601 tgcgaacgtc ttgcgcttcc gtcatatctc atatcagcga gcggaggttg agtttcctga 2019661 agagctcttc cgcacgattc gcataaaacg gttccgaccg ggtttatatg tccgcattca 2019721 catttgactt gcttcatccc gaagtctctc cgggttttat gagattcata taatcgtgta 2019781 tcatgctttc tgtcatagtg ccggtcacca ccttgacaac ttttccttcc ggattgatca 2019841 aaaaggttgt cggaagcgga gatacgtcat aggcatcaag cacttggcga tctgtatcca 2019901 gaacaaccgg gaaattgact ccgtaggatt tcataaaatt atgtactgct atctttgact 2019961 ccccaacatt tacagcgaca atttcaacac cttggctttt aaaatgctta tattggtttg 2020021 ccatataagg aaactctttt ttgcacggtt cacaccatgt accccagaaa ttcaaaaaaa 2020081 cacctttccc ttttaagtca ctgagctcga tacgtttccc attcgtatcc tctaggacaa 2020141 aattcggtgc gtcggaccct tcggatatac tctctttgcc ggcaaataca gcgttgtaaa 2020201 tggtatagcc gagtgcgcag attaaaacga gaaggatgcc ggtccgaatg aataaacgcc 2020261 tttttttctt cattgtccac tgcccccttc cccctattgc agatccattc aattatatca 2020321 ttgcacgttc atttcacatt tcttactttt tgaaggttat gtgaaattta gaaagcgttt 2020381 ttaccgtgat ccgccagtgc tctgagcctt tttacttcgt gaggcgtaag ctctctggca 2020441 tcgcccgtgt gcaggcctcg caggtttaaa aacgcgtatt cctcacgctt cagcttgatt 2020501 acctcatgtc cgatcgcttc aaacatgcgg cgcacttgtc tgttgcgtcc ctcatggatc 2020561 gtcagctgaa taatgcttgt ctgctttttc ttatccaaag acagcagctt cgctttagca 2020621 ggcgctgttt tgccttcctc cagcctaatt ccgcgctcca gctttctgag cagctcttta 2020681 ggcgggattc ctttcacctt cgccacgtat gttttgtcta tttcatactt aggatgcatt 2020741 agcttattgg cgaattcgcc gtcattggtt aaaagcaaaa gaccgctcgt atcatagtcc 2020801 agacgcccaa tcggataaat gcgctgcgga atatttttaa aaaagtccgt caccactttg 2020861 cgtcctttat catcttgcgc tgcggaaata acgcctcttg gtttatataa gagaaagtaa 2020921 accggctctt cgcgttcaac ctttaacccg tttacctcaa tctgatcaga accggtgacc 2020981 ttaacaccta gctctgttac tactttgcca ttcaccttta cttttccttc tttaatcagc 2021041 tcttctgcct ttctgcgcga cgcaactccg gcatgagcaa tcactttttg cagtctttcc 2021101 atgtctttca cctcaagtat tatcttactt ttttcaacct taacaaacaa gctttttcaa 2021161 attcctatgc caaatctaaa aaaaacgccg ttttcaggcg ctcccaaata ataacgtaac 2021221 gatgatgata gatgcaacta cgccgattaa atctgcaaga agtcccacct ttaatgcatc 2021281 acccattttt ttaatgccga ctgctccgaa atacacagtc agtacgtaaa gcgttgtatc 2021341 tgtagatccc tgcatgacgg aagccagcct gccgataaag gaatcgggcc cgtatactgc 2021401 aattaaatcg gtcgtcattc caagtgcggc cgtaccggag atcgggcgga tcagagcaag 2021461 cggcactact tcagcaggga tgccgatagc ggagaaagcc ggttttaaaa gatccattat 2021521 aaaatcaagc gcgcctgatg atctgaaaac agttatagcg acaagcattc cgactaaata 2021581 ggggataatg gaaaaggcaa tttctatccc ctctttcccg ccttcgacaa acgattcata 2021641 tgtcggaacc tttttgatcg ttccataaag aagaattccg gcaataatga ttggaatcat 2021701 ggctaaagac agccagttga tgatttccat ccgctcacct tcccttcttt ttgcggcggt 2021761 aataaaaata ccgatcaatg ataatggcac cgattccgga aataagcgtt gccaaaatgc 2021821 ttggcccgac gatatctgtc ggcgttttgg aggaataagc cattcggaca gcgatcaccg 2021881 ttgtcgggat gagtgtgatg caggacgtat taacagctaa aaaagtaatc atcgaccggc 2021941 ttgcttccga tcggtttccg ttcagctttt tcatttgttc cattgcttta atgccaagcg 2022001 gagttgctgc atttccgagg ccgaagaaat tcgccataag attagataaa atatagccca 2022061 tcgccgggtg atccggcggt atatcaggga acagtttaga tataaaaggt ctgcacatcc 2022121 ggctgaaaat atccaaaagc cctgactgct cggcgatttt cattaagcca agccagaaaa 2022181 caagcacgct catcaatcca aatgagatcg taatcgcttc tttcgcaccc ttaaacacgg 2022241 cttcatttac atcttgcaga gttccgttgc acatcgcaaa aacgagtccg atcacggtta 2022301 aactgaccca aattatattg accattttgc tccgcctgcc gcattcagaa agattgattt 2022361 aaacgtttca aaaaattgtt tcttcggttt ttgatgccgc tcattttcat aatagatcgg 2022421 cacttttgcg atggttgcat cgttgaacat gatctccatg tgccctacga tgtcagggat 2022481 tttcgaggca tctttttccc atgctttttt cggcttgagc agtgtggtat taatttttac 2022541 attttctttt tcctcttcgg tcagcaaata ggtgatatca cgtttgataa aagccttcga 2022601 ttcataaaat gtgcctttca gctttggaat atcccctttt tttgcaatta aataggtttg 2022661 ataatgctca aacacatagt taaacatctt catatggtca tcccaatcat tagggtcatt 2022721 aatggtgacg gctatcaggt caatgccgtc ctttgaagcc gtagagacca gtgtccgttt 2022781 tgcaagtttt gtatagcctg tttttcctcc tgtgctgtac ggataaagca tggtcagcag 2022841 tttgtttttg tttttccata cgctttccat cgtttccgct ttgtatattt ttgtgcctga 2022901 aatcttttga tagtctttca gcttcatagc atacttagtt aaaatggcca tgtcataggc 2022961 tgttgaataa tgattttcat ggtcgtccaa tccgtgcggg ttttgaaaac gggtgttttt 2023021 cataccaagc tgctcggctt tttgattcat catataaaca aacccatcga ggctcccacc 2023081 gacatgctca gcaatcgcga cagcggcatc gtttcctgat cttagcatca ggccatacac 2023141 aagatctttc agcttcactt tttgaccttc tgttaaataa atggcggagc cttctgttct 2023201 gacagcattt gccgaaaccg tcactgtttg atccattttg ccggattcga tggcgaggac 2023261 ggcggtcata atttttgtga tgctcgcgat ccgccttttt tgatgctcat ccttggcata 2023321 taacactctg cctgacgcac cgtcaataat gatcgcgctt tttgcactga catctatagc 2023381 agcatgtgct gtattcacat ttacggttgc aataagaaaa gaaatcatga tcacgaatac 2023441 tgcttttttg aaaatgcgca tgtttgctca cgtccttgtg gtggtttgta caagtttatg 2023501 cgcatgtcca tcagttatga ataacaatta tatttctgga agcaaacata aaaaaactct 2023561 ccctgaaaaa gggagagtaa acgttatctg attggcgcca tgcttgatcc ggacgcttcg 2023621 taatgagcca gctcttccct catcttcaga aaggccgcgc tcaacggcaa taataattgc 2023681 tcaagcgacg caggaacagc atgataaaac tcaattgcgc tgaccccggt ataagacgcc 2023741 cggctatttt cacaccacgt gtcttttttc ggcataaaga actcttcaat gcattggtga 2023801 tacacattat aaagtgtttt ttccgctctg gcttcctgaa aaggctcctg catcaggaga 2023861 cgacggcacg cttctgcgcc tccttcacaa aatactgcca ttcttctcag agtgctaagc 2023921 acatcacagc agtatccttt ttcaataggc aattcagcct gtaaggactc aagcgtcgtt 2023981 tgatttaggt aatcgttcac ggtattgaca accattgata agaattcgcc tgttttttga 2024041 gtctgcgctc gcacaatcga atgtcccatt tcgtttggta tcttcccctc atgtatttgt 2024101 ctctcacatt ttgcttcttt catgatagct tcttccttat atcttatgat gatgaaaaag 2024161 cgcgattcat taaacttcta ttttatatct tcgaaggttt ggttaaagtt ttcaaaaaat 2024221 aaatctgctt cttcttgaag aacgtcttct tccgcatttt caggcagcgg cggaagctcg 2024281 tccagcgttt tcagaccgaa ttgttcaaga aaagtcggcg tagtaccgta taaaatggcc 2024341 cgccccggac catcggcacg ccctacttca cacaatagcg ccttcgcgac aagactgtgt 2024401 aaaatccgct ctgattttac tcctctgatt tcttcaattt ctgctctcgt aattggctgt 2024461 ttgtatgaaa caatggccag tacttctaaa gatgcttgag aaaggccctt tgacggcact 2024521 tcaatcagtt ttttcaagta aggcgcaaag tcttttttgg tagagagcat gtacgtatct 2024581 gcatactcaa taagttcaat ccctcgtgta tctccgcggt attcgtccgc cacatccgcc 2024641 atgatcgtgt tcagttcagg ctcttcgatt tcaagcactg ttaacagctg cttttttgta 2024701 agcccttcat cgcctgccgc ataaagaagg gcttccacaa tagctttcca attcacgata 2024761 tcaagcccca tgaatggatt cactccccgt aatgtaaata tctgaaaaat tgtgctcctg 2024821 ttcaatgagg accagctgat ttttcatcag ctcaagaaca gctagaaagg tcactactaa 2024881 atgttctttt tgctcatatg gaaacagatc cataaagtta attctcgttc ctctagattt 2024941 caagctgtgc acgatttcgt tcattctggc ttcgattggt atgtcctgtc ttgtaattgt 2025001 tgtttccatc ggcctgttta tttttttgcg tttcagcact ttttgaaaag ctccgatcat 2025061 atcatagacc gtgacagaga gcttttgctc agactgtttt acttcttttg catattcact 2025121 caaatcactc ggcggtttcg tgaacgattt ttgtctttct tcttcccgtt cttttaaatc 2025181 cttcgccgca tctttatatt ttcggtactc aatcagcttt tcaatcagtt cctcccgcgg 2025241 atcttcttct tcaagtaatt catcttcaaa aagctcctcc tcttgcttcg ggagcagcat 2025301 tctgctttta atgctgagca gcgtggcagc cataaccaaa tactcgctgg caatgtcgag 2025361 ctcaagcacg cgcatcgtat gtacatataa taaatattgt tcagtgatct tcgccacagg 2025421 tatatcatat atgtcaattt caagacgatt gattaaatga agcagcaggt ccaatgggcc 2025481 ctcaaacgta tcaattttca cttgatattc ttccatcatc tcaccatttt caagtatcac 2025541 tctcattgcc ggaaaaactg gctaccctat agtataagcc accaaaaagc tctcgtccaa 2025601 tactatttca tatcctgttt tgaaggagtt tgtacagaat attcaaaaca caagaggtgt 2025661 ttgctcggag cgcagaagcg ggagaaaaag cctttgcttc tggttttcct ttctaagaag 2025721 cactagaggc cgggcgttct tttttccttt tatcccttct atggtacact aaaagcacat 2025781 taaaggagga agcaccttgt atccgaaagc ttatatagat tatctcgttg agtttcatgc 2025841 gacacgggat tattttgaat gccatgaaat attagaagaa tattggaagg aagatccgcc 2025901 aaagaaacga aaacgctatt gggtgggctt tattcagctt gcagtggctt tatatcatca 2025961 cagaaggcag aatacagccg gggcaaaaag actgatggcg aacagcatcc ggattcttca 2026021 agcagaacac cgggcagtcg aagacttagg gcttgatcat ggccgtttgc tcgaacttat 2026081 gcaatcggtt tacgaacaaa tcgaaaccgt ctctgcctat aaaagcatta tactgccaat 2026141 caaagatgag aaactggagg aagcatgcag gatcgaatgc aggaaaaaaa agtatacatg 2026201 ggggcagccc agtgcactca gcaacatatt tcttatcgac aaacaccgtt tgcgggatcg 2026261 gactgacgtc atccgtgaac gtgaaaaaga aatagaacgc agaaaaaaaa gcagagactg 2026321 atcacagcct ctgcttaatt attgtatgaa atgtcttgat cctgctgacc ttgacaacgt 2026381 tcgaaaaagc tctgcgttaa ttcatttgga accagtactt gcgttttgaa taaatgcttt 2026441 aaagcatcca tcatctgttt tccgattcct tgatggcgat gagaaggatt cacactgata 2026501 tgccggatct caacctcaga atcctttttt tcgactccga ttgctccgac gatatcctcg 2026561 tcctctttcc aaagaaagag ctggcggtct gtatccgttt cgtagtcctt aattgtctgc 2026621 tgaagctgct taaggtcttt ttcattcggc ataaacgaaa gaagccccat cgcaatcttt 2026681 tcaaacgatt ttttataacg aattaacata aaaacccctc tatatccaaa atgtccagtc 2026741 tgctattaac ggatacgaat aggtgatccg ttttctcaca ttatatcatt ttcgccatat 2026801 ttttaaactg ttttcagcaa attattcaaa tgagcggttt aaatttgcca tttcaatggc 2026861 agaaacagca caatctacac ctttgttgcc cgcttttgtg ccggcacgct cgatagcctg 2026921 ttcgatgttt tcagttgtta caattccaaa gatgacaggt acaccagtag tgtttgctgc 2026981 ttgcgcgatg ccttttgcag cttcattgca gacataatcg taatgtgtcg ttgcgcctct 2027041 gatgacagtg cccaatgtga taatagcatc atattttttt gtttccgcca tttttttcgc 2027101 agcaaacggt atttcaaatg cgcctggaac ccaagccaca tcaatgtcat ttgtgtctac 2027161 gccatgtctg agcagcgcat cttctgctcc gctcagcagc ttgctcgtaa taaaatcatt 2027221 aaatcttcct actacgattc cgattttaag acctgtacca actaaatttc cttgtatgat 2027281 attcatatga ttcccatcct tttttgtgat atttgtgatt agaaatgaag taaatgacct 2027341 agcttgttca ttttggtttg caaatatttt ttattgtgtt ctttcgcctc catttgaagc 2027401 ggcactcttt ctgaaatact gagtccgtag ccttcaaggc ctgcgatttt tcgcggatta 2027461 ttcgtcaaaa gcttcatatt ccggacaccg aggtcgcgta aaatttgtgc tccgatgcca 2027521 tagttgcgaa gatccggcaa gaatccaagc gcctcattgg cttctacggt gtcatagcct 2027581 tgttcctgaa gcttataagc ttttaattta ttgattaaac cgatgcctcg tccttcttgg 2027641 cgcaagtaca ggagcactcc acggccttct gcggcaattt ggttcagcgc ggcgtgcagc 2027701 tgcggtccgc aatcacagcg atgagagcca aacacgtcac ctgtgagaca ttctgaatgc 2027761 acccggacca ataccggttc ttctccgaac ggcacatctc ccatcacaaa tgcgacatgc 2027821 tcttttccat ctacctcatt tgtgtatcca taaaccttaa atgtcccaaa atcagtaggc 2027881 agcgtaatgt caacttcacg ctcgacaagt gttgtcagat tgtaacggta ttgaatcaaa 2027941 tccttaatgg tgatcatttt taattgatgc tttttcgcaa tttcaatgag ctcaggcact 2028001 ctcgccatcg ttccgtcttc attcataatt tcacaaatga cgccggctcc tggagatccg 2028061 caagcttcag caagatcaac agcagcttct gtatggcccg ctcttttcag gacacctcct 2028121 tttttcgcaa tcagtggaaa aatgtgcccc ggacgctgaa aatcagatgg cacggatttg 2028181 ctgtccagca atgcttgaac ggtaaaagat ctttcttgag cgctgatacc tgtcttcgtt 2028241 tcacgatggt ctatgcttac ggtaaatgca gtgtggtgag agtctgtatt atgctcaacc 2028301 atagggtgaa gatcaagcct gtctgcgatt tcctcactga gcggcgtgca gatcagtcct 2028361 ctcccatgtg tcgccataaa gttaatgact tccggcgttg catgctcggc aagagccaca 2028421 aagtctcctt cattttctct gtcttcatca tctacaacga tgatgacttc gccttttttt 2028481 aaagcgtcca gtgcttcttc tatcggatga aacatgcaaa tcttcctctc taaaagccgt 2028541 tttcgcttaa gaaggctttt gtaatggttt gttgggtctt attttcattg gctttatgca 2028601 aaaatcgata catatatttt ccgatcatat cgcattcgat attcacttta gagccgatcg 2028661 ttttttctga aaagatcgtt tcgctgatcg tatgcggtat taaggagatc gtcactgtgt 2028721 cttctgtcag gccgaatatg gttaagctca cgccatccac agtaattgat ccctttaaaa 2028781 ccaatgtttt tgttaatgac gggtccattt ttaaatcata gtaaactgcg ttgcttttct 2028841 cttcaattcg tgtgatttcc gcagttccgt cgacatggcc tgagacgaaa tggcctccga 2028901 aacggccgtt tgccgccatc gctctttcca gatttacttt gcttcctttt gttaaatcat 2028961 tcagtgacgt agctttgact gtttcaggca taacatccac tgtgaattga ttttttgtaa 2029021 aatcagtgac agtcagacaa atgccgttca ctgcaatgct gtcgccaaga tgaacatcct 2029081 ctaaaatctt tgagcattta atagttaagg ccattgcatg ccctgctttt ttcatggatt 2029141 cgattgtgcc tgtttcttcg ataattcctg taaacatggt caccatccta ttcctttgtc 2029201 ggttttgccg tcagtttgat atcacggccg atttgggtta tatcagtgaa ttgtaataag 2029261 gggacatctt tcattgattg aaaaccttca ccggagatta agctgggagc atgcgttcct 2029321 ccgattagtt taggggcaaa atagaagatg atttcttgaa aacagccttc tttgacaaag 2029381 cttccgtgaa cagctgaacc gccttccaca tacaccgaca tgatgccttc ttccgctagg 2029441 atcttcaaaa catcaggaat ttgaatgcgc tcggtttcaa gtgtaaatat gttcactccg 2029501 aaagctgaaa gccgtttttt cttttcctcg tctgcgcgtg ccgtcgtaaa aatccatgtc 2029561 ggcgctattt gatcgcaaat cactttagcg tcctcaggaa tcgagagtac ggtatcaagt 2029621 atgacccgaa ccggctgttt tgttacattc ggcagtctgc aggttaagct cggattgtcg 2029681 gctttcactg tgccaactcc gactaaaatg ctttggtgtg ttttcctgta ttgctgagca 2029741 tcctgtcttg cagcctctga cgtgatccat ttgctgtcac ccgtgctggt agctatcttg 2029801 ccgtcaaggc tggcagccgc ttttagcgtg acgtacggaa ggcctgtcct cataaagtgc 2029861 agaaattttt cattcagcct ctccgcctgg tctgccagga tgccttccct tacctcaatg 2029921 ccagcttctt tcatcatgct gatccctctt ccagccacaa gcggattagg atctctcatc 2029981 gccacgaaca ctcttttgat accagagttg ataatcaatt ctgcacatgg cggtgttttt 2030041 ccgtaatggc tgcacggttc gagtgtaacg taaatgtcgg caccctctgc atgtgctcca 2030101 gccatatgga tggcatgaac ttctgcatga gcttcaccat attttaaatg ggcgcccatt 2030161 ccgacaattt gtccgtcctt tacgacaaca gcgccgacga gcggattgga ttcggtctgt 2030221 ccttcgccct gcttcgcaag atctaaggcc agcttcatat aatactcttc catttgtttc 2030281 cctcccctct tttgttattt accgtcaaaa aagccccgaa tttataaaaa attcggggct 2030341 ttaggtattt tacgcaatag gaaataacac tatgcatttt taaacatttt gcatagcggc 2030401 tcatcatcct tctcccatcc agactttcac tgtcggcttc agcttaaact gaatccaccg 2030461 cgtgcttatg cacacgggtc acgggctcta aagcaaatgt gctttactac cgccggtcgg 2030521 gatttccacc ctgccccgaa ggatacaatc tttattcatt tgtccttatt ggttattata 2030581 gcgatccttt ttaaagtacg caatgaaata aacttacaat ttgagaaaaa caaaacatca 2030641 cccttcgatc cgaaaggtga tgttttttaa tcattcactt ttgcaacctt gattaatccg 2030701 tcgatccgct ttgatttgct gaagtaagcc ttaatcttgt caccttcttt tatatcagat 2030761 aaatcctgat ttaatttttt tccgttgaag atgattttcg ttccgttttc tgctactcca 2030821 tgatactctg agccgtcaat tttcgtcact ttatattcct ggatggtgta ttcctcttct 2030881 tccgaggaca aggtttgtcc aattgctgtc ggaacatcct tcagctcaat atcatttatg 2030941 tacatataac cgcctgcaag taaaagcaaa agcactaaca gaatggtaat cttggttttt 2031001 attcttccca tttctaaacc tccagccaat atgaatctat tcattcatat gagttattcc 2031061 tttttttcat gaataaaaaa ccgtaaattc tcgtaaatta ttaatataac gatgcataac 2031121 gggaatatgt ttcacatttc tgcaaaaatt tcttttctat agatatacga atttatgttc 2031181 tgtttttagg ggatgaccgt aaaaaagata taaaaaaagc agccccaatg ggaagctgct 2031241 tgatcctaat ttgttttgcg catttcgtta aacgggtaga aaacaaactt tgacgtaccc 2031301 gcaatttgtt ttttcgtgaa gaggccaagg ccgttacggc tgtccatgga attgcgacga 2031361 ttgtcaccca tcacaaaata cttgttatca ggcactttaa ccgggccgaa atcatcggtc 2031421 aaatggtcaa aaccgtcctg tttcgctctc tttttattag ccgccaaata aggttcgtcc 2031481 acctttttcc cgttgatata gagctggtca tttttcatct caaccgtatc gccgggaagg 2031541 ccgataatac gtttgacata gtgaacatca tctccgttta acacgacgat gtctcctcta 2031601 tcaaactcgc cgatgtattt gactgtcata ttaacaaaaa ccctttcacg gttgtgaagt 2031661 gtaggataca tagagtcacc atcaacgaca tacggcgcaa aaataaagtt gcggatgagc 2031721 aaagcaagaa cgacagcaat cacaattgct tttgcccatt ctaatattga ctttttcttc 2031781 gaaacatttt ctgatttcaa ctgatttcct ccaataaaca acggtcttca atttatgtta 2031841 tcacgaatcg aaaaaaaatc ccattaggac cattgaagtg attttacaaa ctgttaatct 2031901 tcatcttcta cccacatcat gcctattttt tcttgtcgat cataactagg cctgaaaata 2031961 ttgaaagaaa tgaatcgcat aattcagaag cgatggactc agaagaaaga gagttctcat 2032021 atgcaaaatc tttagatcgt atataaagca tgaggttacg ggcagtttgt tcatttactg 2032081 cattccattg atctcccagt ccatgatacc catggcactt gacaaaacaa ttaacgtcat 2032141 gaaggttact ggaatgtttg cggcaaccta tttcacaggt gataaccgca ccccgttttt 2032201 tgctttcata atatgtttaa aatcattcaa gctcgaaaac atggatcagc ctccaaaaaa 2032261 taaatccaat atattcccgg cagttgaaga ctctttatta taaaactctg aatatccgca 2032321 gttcttacag taaaccacta gaaatcggtt atgctgcacg tcaaacagct ttgataatcc 2032381 cgtgccggtt gtagctattt ctttttgtcc ggcttcagta ctaccgcatt ttatacagcc 2032441 tttgttgttc atatcgcgat ctccttttca ttacatcacg tttgtttgat ttattttact 2032501 acaaaatatc aatcccaatg acccgtacta ctttaaagtt tacttaattt tgattacata 2032561 ctaattgggt tcgtttctca gcttggtaaa tcttctggag aaacggaaaa gctccatgac 2032621 caaaacattc aaactcagcc aaacaccgcc gaaggcgtaa cccgcagcaa catcactcgg 2032681 atactgctca taaagtacac acggctcagc ccgatgagga ataaaacgat aataaacaaa 2032741 aaaatgcaac agtttgcaga cgcgtcttgt gagaatgacg aacaaaaaga taagcacaaa 2032801 aaccaaaaat gacaaatgcc gttaaagtct gttcgctcgg gaatggatat aatacatgac 2032861 tttccaaagg agcgtgaaca ggatgaaggg aatgaaagag ccgtctgatt ccctcttcat 2032921 aaagctcccc accaatgact aggaaaaata agaaagagag ttcgattttc cgatcttgcc 2032981 ctctgaatac cgtccaaaaa aaagttagaa caataacggc taacagaaca cctctcgacg 2033041 caaaagcttt ctgaattgca gctgggccca gtctataccc gatccaatac gacatgctca 2033101 ctcccacagc tccccaatcc ggccgctaac atgcttagca cccagtttaa cttttcttga 2033161 aacacgagaa caccggcaaa ctctcccggt ccaagtaaag ctagaagctc taacatcaag 2033221 acaataaaca agacggcata tccgtactgt tcgagcaacc ccgtcaaaac ttgcatgtga 2033281 ttctccttaa acttttttgt tcttttatca ttcccaatcc actttttgta taatcagcac 2033341 aattttatct tcagtcgtcc aacaacattg tctatggcgg gatcttctct catacattct 2033401 tttttgacat aggaggagca atagcatgaa atgggaggaa acaaaagata cgcagggagt 2033461 ttgccaaaat tttgggcagt tcgttctgcc accgagtcag gtgtttgttt gcccacctca 2033521 tcccttgtca attccccatt tttcccgttt gaggttcgaa atggtaaagt atttcactta 2033581 gtttcttaca tgaagaggta aattctttgc tcaccgaact aggatagcgg cgtatggcga 2033641 tttctacatt gcataaccac tggttattta gtgagccgtg agcaatgtat atgcactttg 2033701 agtcagcaca ggatgatcct attacattcg ccagaaaagc agctgccgca ttcagagtag 2033761 ttaaaagaat agacagatat ctgggcttcc ggaagcttta aaggaggctc ttttttcgag 2033821 catttttata aatcaataaa aacaggcatc tcctaaatat ttttgccgat aagtttacgc 2033881 taatcaactc tagcactaat acatataaaa aatagaatga tatgaaagga gacttgatag 2033941 tatgattgat tatcctatta atataaacaa cgtttccggg aacagtgtaa ttaacgtagg 2034001 cggcgctttt atgatcaggc ctttaacttt gtccaaatct gtgtttggct ccggaggttt 2034061 aaacacagga attgtctttg aaaataactt tgtaagcaaa gctaaaatga ttaatcatca 2034121 atttactgat caaaacgtca ccaaaacttt ttaatgtatt caatacacgg gggtcactaa 2034181 ctaaacacct ggttttgcca accgccatca gcattcggcg gttttttatt gaacattttt 2034241 ggccaataaa aaaagcttcc tctctaagag gaagcctttt gcctgccgat tagccttcta 2034301 cacgaacttc tttcatgaca tcgccattag acatgttttt cgcgaattct aatccgcttg 2034361 ttactttacc aaatacagtg tgaacaccgt tcaaatgagg ctgtggctca tgaacgatga 2034421 aaaattggct gccgccagtg tcttttccgg catgtgccat agaaagtgcg cccgcctcat 2034481 gtgtatgcgg gttgccttct gtttcacatt tgattgtgta tcccggaccg cctgtaccag 2034541 ttccgtgcgg gcatccgcct tggctgacga agccagggat cactcggtgg aatgtaagcc 2034601 cgtcataaaa gccttcgttc gcaagctttt caaagtttgc aacagttcca ggtgcagctt 2034661 caggataaag ttcaaattca attttgttcc cgtcttctaa taaaaagtaa cctgttttca 2034721 attgtatgcc tactttcttt attttaattt tcaaaggaga ttatgtatag gttatagcct 2034781 gtctctcctt gtcgcggcta ttataccaca cctttcgggg gaaaacgaat ctcccgagct 2034841 ttactaaaaa ataaaaatga aacctgaatc tctttatctc cgtctaacct aacggaactg 2034901 tatttttcat gattcaggtc ctcacaaagc agcactatcc agctgcttgt gaaattgaag 2034961 gaggtcaaac tgctttgaag aaaatttgga ttggaatgct ggcagcggcc gttttgctgc 2035021 tgatggttcc gaaggtcagt ctcgcggatg ccgcagttgg agatgtcatt gtaacactgg 2035081 gtgctgattt gtcagaatct gacaaacaaa aagtgcttga tgaaatgaat gtccctgata 2035141 atgccacaac ggtaaccgtg accaataagg aagaacatga atatttagga aaatatatat 2035201 cgaacgcgca aatcggatcg agagcgattt cttcatcgtc aatcaccatt gccaaaaaag 2035261 gctccggatt gaatgttgag acccataata tcagcggcat cacagatgaa atgtacctga 2035321 atgcactgat gacagccggt gttaaagatg cgaaggtgta tgttacagca ccgtttgaag 2035381 tatccgggac tgccgcttta actggattga ttaaggcgta tgaagtttct tctgacgaag 2035441 cgatctcgga ggatgttaag caggtcgcca accaagagct tgtcacgaca tcagagcttg 2035501 gagacaaaat cggtaacgaa aatgcggcag ccctgattgc aaaaatcaaa gaagagtttg 2035561 ctaaaaacgg ggtgcctgat aataaagctg acatcgaaaa acaagtggat gacgcagctt 2035621 ctgatttaaa cgtcacactt acagacagcc aaaagaatca gcttgtctcc ctattcaata 2035681 agatgaaaaa cgctgacatt gactggggac aggtcagtga ccagctagat aaagcgaaag 2035741 ataagattac gaaattcata gaatcagatg aaggcaaaaa cttcatccag aaagtcattg 2035801 atttcttcgt atctatctgg aatgcgattg tatctatatt caaataagaa aagcgccgaa 2035861 aaatcggcgc tttcttttat tgctttacac ccgttttaaa tggcagatca agttttacaa 2035921 tatcttcgta tgtttctcgc ttcacgacta aatgagcctc accgttttcg acaaatacaa 2035981 cggcgggtct cggaatacgg ttataattgt tggccatgct gtatccataa gcgcctgtac 2036041 aaaaaacggc aagaagatcg ccttctttta cttccggcag gtcaatatcc caaatcagca 2036101 tatctccgct ttcacagcac tttccggcaa ttgataccgt tttgtcatgc gcttctccga 2036161 tcctgttggc tgccgcagct tcatatttag cttggtaaag cgcaggacga atattgtcgt 2036221 tcatgcctcc gtctacagcc acatattggc ggacacccgg cacttctttt tgagagccaa 2036281 ccgtataaag agttgtgcct gcgtctccca cgagagaacg gcccggttcg atccaaattt 2036341 ccggaatgtc aaaaccgtaa cgggaagcat tttctttcac agcttcgata attttttcaa 2036401 cgtattcagt ggcatgaagc ggttcatcat cttccgtata acgaatgccg aaacctcctc 2036461 caagattcag caccttggat acaaatgaat atgaatctct ccattcgtct agttttttga 2036521 agattttttc cgctgctaac acaaaaccgg ccgtatcaaa gatttgcgag ccgatatggc 2036581 aatggacacc cagcagctga atgtgttccg attgtaatac ttgttcaatg gcccgttcag 2036641 tttgtccgtt atgaagatcg aaaccaaact ttgaatcttc ctggcccgtt gtaatgtagt 2036701 catgcgtatg cgcttctact ccgggcgtga tccgaagaag aacatcgatg gagtgacccg 2036761 tttctttaca taggtcttca agaagcgcga tttcatagaa attatccacc acaatgcagc 2036821 cgatgcggtg ctcaagcgcc atccgcagtt cttccctgct cttattgttt ccatgaaagt 2036881 ggatgcgttc tgccggaaag cctgctgcaa cagccgtata tagctctcct ccggatacga 2036941 catctaaaga aagtccctct tcctcagcga gctgaatcat tgcgactgat gagaatgctt 2037001 tgctcgcata tgccacctgt gctttcagcc ctgcagaaat aaacgcctgc ttaaagcttt 2037061 tagcacgctc acgtattaaa gccacatcat atacgtaaag aggtgtacca tatttctccg 2037121 ctaaatagag agcatccaca cctccgattt ctaaatgacc atgttgattt tgtctgcttg 2037181 tgccgtgtaa gaacaatgtc attccctctt tctccgctta tggatgaaag gacagtttta 2037241 tggactgtcc cttcataatt aagacataca ttatcatact cttcagtcag tttcaatgcg 2037301 attatgaatt ggtaggctgc cttaagcgat ttttggggtg aacgatgctg ggtcttactt 2037361 ttgcgccagg tttcgctgtg cggacaagaa cctgccacag cgcctttccg ttaaagggaa 2037421 tcagcggcca taagtacggt gtctgaaggg atttgatgct tgccatggca ataattagca 2037481 ctgtaaatcc gatgacgagc ccttttatat gaaataaagc aacgagtatc atgaggacaa 2037541 gacggctcat tttgtttgcc aagcttaatt cataactagg cgtcgtaaag gttccaatcg 2037601 ccgcaagtga gacgtacaga atcacctcag gagaaaaaag gccgacctca atcgcaatct 2037661 gcccgatcag aacagcggca attaaaccca ttgctgtcga taaagccgtc ggtgtgtgaa 2037721 tggcagccat tctgagaaac tcgattccta agtcagctaa aaatatctgc aggatgatcg 2037781 ggatatgcgt atctttattt aaaccgataa atttcatgtt gtccgggagc agatcaggct 2037841 gaagcacaaa gagaaaccag atcggaagaa ataaagtaga agcaagaata ccgaaaaatc 2037901 ttacccatct taaaaaggtc ccgactgaag gcgcctgcct atattcttca gcatgctgca 2037961 catggtgaaa taaagtcgtc ggggtaatga tcacactcgg cgatgtgtcc actataatga 2038021 taacatggcc ttctagaaca tgatttgcgg ccacatccgg tctttctgta tagcgcacga 2038081 gcggaaaagg attatagctt tgattaacaa tgaattcctc gacagttttg tctgccattg 2038141 ttaatccatc gacatcaatg gatgcaattt ctttttctac gatctcaacc agatccggat 2038201 cagctatatc ttctatataa caaatgctta aatccgtctt tgaccgctca ccaactttag 2038261 tcatcttgac tcgaaggcgt tcgtctctga tccgccttct gagaagggcc gtattgacga 2038321 cgatattttc aacaaatccg tctctggctc ccctgaccac cttttccgta tcaggttctt 2038381 ccgggtttct gcccggatag cttctgacat caattataaa tgcgaagcct gcaccttcaa 2038441 caatgacagc gacgagcccg gacagcactt ggtcggtggt ttcatccaag gtttttactt 2038501 tttcgacctg ggcgttaagc agcctgtttt cgacgatgtc gaccagctca tcagggtctt 2038561 ctttccgatt gttaatggca acaagctctc tcattaaatg aataatatag gctgtatcgc 2038621 ataatccatt tagatagtaa agctggatct ctttatctaa aatcgtgagc ttgcgaacac 2038681 ctacatcata gctcgtcccc atcccaacac ggtttttgaa atactcttca tttttagctg 2038741 gattccgata aacccgaatt ttctcttcct tgtggtccgg catgataccc gctcctttct 2038801 aaaataaact cgaccgcttt catggtgatt ggcgaccctt ttgagatatc gtcttttctg 2038861 cccattttgc cgatatcccc gataccgaca ataagcggga gatcaagttt atcaaggcaa 2038921 tagactgtat ctccactcat tctgtggtca tcaaattccc tttccccgac tttatcgacg 2038981 ccgtattcag ttatttctcc attgcggtca atgcttacat cgaccctggt ccattcagcc 2039041 tgatgtgttt ttgacgcgac cgcaatcaca ccgagcactt caatagacgg atgggttgcg 2039101 acataggtta gagcggcttc tcccgggccc tctccttgaa ggccggagtc gtcaaacatg 2039161 acaaatacag gatcatacgg tgctgaggcg atcagcttga caagctcggc gccgctgcgg 2039221 gtggaaggat tcccttttga ttgtgaaata catcggcctc ccactttgct tgcggcgtat 2039281 tcaattgttt tagcggcata aacatccccg tctgttacca gtatgacctt gcgttttgtc 2039341 gtcatgtcgg cattatcctt tcggtttgaa aataacagct acgataaagg cgaaaagaat 2039401 agcggctgag ataccggccg aggtcagctc aaaaatcccc atgccgattc cgataaatcc 2039461 gtgtatatgc gcctgatgca tggcgccgtg cagaagactg tgaccgaagc tgacgatcgg 2039521 aacggtggcg cctcctccgg caaattcaat aaatttatcg taaatgccga aaccatctaa 2039581 tattgcaccg attacaacaa atgatgtcat gacatgagct ggcgtcaatt taaaaatatc 2039641 caagagcagc tggccgacga tacagatggc cccgccgcag acaaaagcca aaaggtagtc 2039701 catattaaga tgcacctcct gcacgctcaa atacaacccc gtgggcgata gtcgggatgg 2039761 tttctttttg ctggatcatc gtcgggctta atagcgcccc ggtcgccacg acaaatacac 2039821 ggtttagttt tccttctctc agctgcttaa aaatatgaga gtaggtgaca accgctgaac 2039881 aagcacagcc gctccccccg gcaaagacct gctgatccgg agtgtaaatc agaagcccgc 2039941 aatcatcatg ctttgtgccg actggatatc catcttcttt taaaatgtct tttacgattg 2040001 gagaaccgac gcctgacagg tcacctgtca ggattagatc atagtcatcc gctgtccggt 2040061 tgagatcttt aaagtgctgc ttaatcgtat cagctgcagc cggagccata gccgatccca 2040121 tatcaaaagg atctgtaatt cctaaatcag aaaccttccc gacagtcgca cttgtgattt 2040181 ggatatcacc cggtgtctga ctgatgacaa ctgcaccgct tccggttaca gtggaggtag 2040241 cagtgtccgg tttttggcct ccgtattctg tcggatagcg aaactgtctt tccgcagttg 2040301 cattgtgact gctggtggca gcgagtgccc ttttggcaaa ccctccatca actaaggctg 2040361 atgcgacagc cactgtttcc attgatgttg aacaggcgcc aaacatacaa agaaatggga 2040421 ttttcaagtg tcttgccaca tagttagccg tcacgttttg gttcagcaag tcgcctgcca 2040481 gcaataggtc aatatcatct tttgtcagat tgtttttttg aagtgcaaca ttaacagcgt 2040541 cttccatcag ctgccgttcc gccatttccc agcttttttg attacaatgc atttcgtcat 2040601 aggttttatc aaataaagag ccaagcggtc cgtctttttc ctttggtcct gctgccgttc 2040661 ccgctgagtt gacaaatatg ggatgttcaa atacccaggt ttgctttcct gttaatttca 2040721 ttttcttctc ctcctatgac atcagtttct caaaagcaaa ccgaatcatt ccaacgatgt 2040781 atgcagctac aactccgaaa acaataacat ttcctgccag tttaaacata tttgtcgcta 2040841 ctccaagcac taatccttcg cttttatatt caagagccgc acttgccata ctgttggcaa 2040901 aacccgtgac aggtacggct gaacctgcgc ctgcgaattg tccgattctg tcatagattc 2040961 caaaccctgt aagcagggca gaaattaata tcagcgttgc agctgttgga ttccccgcag 2041021 ttttttcatt gaaatcaaaa aaatggatat aaaaattttg cagaccttgc ccgattgcac 2041081 aaatcagtcc gcccactaaa aaggctttta cacagttcca gacgtaaggc ggcttaggct 2041141 gatatgtttt cacttttgat ttgtaatttt cttttatgtt tgtcatcttg aaacctcctt 2041201 atgaatggtc aataaagtac agccagtgaa ataaagatcc cgcgattttc ccaatcacga 2041261 tggccattaa cagaataatg attttacttc tgagcccgat tcgtttcgcc aaaatcggca 2041321 ggacatttaa aacctctgta agagcagccg ctagcatccc gacgaacaaa cctgccagaa 2041381 gcccgaccgg cacagctatc cattttgtta gataaagatg attcatatga agcgtctccc 2041441 atcccccgca aaccgcgcca agaataacag ccgcttcata agcctgaaca aatctcattg 2041501 ttttggtgag ctgcatcagc cgcggaatga ttcccattac ggttaaaaaa gcaacgaaac 2041561 ccgcccccac cgttatgcct ccgccgagcc cgacaaaaat gatgaacaat acactaacga 2041621 tcatgcagat cctttatggt ttcttgattc tcatgcatgg ccacatattg atcgagatca 2041681 agctgatagt taaacatctc aacctccagc gggctgggct cttcatttag gcgcttttta 2041741 aatatgtggt taaaaaacac gatcatcccc agtcccaaac cgatgctgta tgggatttga 2041801 agcaaatatg gatagtcatt cctctctccg gttatgattt catatagtgc gatatgaaca 2041861 tctctcatgc ttacatcctc atgaaagttc atgatggcaa gacacgatcc aataaacaga 2041921 agcagccaga caccgataaa tagaaccgtt gataaatttc gctttcgata ctgaatttca 2041981 acaatggttt ctgctccgcc tacggtttga acatcaattg tcgggtcttg taaatgaatg 2042041 gctctgagga cttgtatgat atccagaatt acgatatttt tatctttttc gctcacctga 2042101 taaagcggca tagccgaaag tttctttttc agctgaagct gcccttctat ttgcgcggca 2042161 tctccaacgg taataatatc ccctggatgt gccagcactc ggtggcgaag ccggataaat 2042221 attcgtcgtt ccatcattga tcaccatctt tcggtggtta tatatgtagt atgtggttcg 2042281 attttgttct cattcatccg ctcgaaaaga ccataaatta ccacgctttt gcacaaaaaa 2042341 gctagcctgc actgcagact agccatccgt atgatccatt tgaaccttga tctgttttaa 2042401 tattttcttt tcaagcctgg aaacctgcac ctgagagatc ccgagccgct cagccacctc 2042461 ggactgtgtc tggtctttat aatatctgag atagacgatt agtttttccc tttcctccaa 2042521 atcgctgatc gcttctttca gcgcaatttt gtcaaaccat ttttcttctg agttgtcagc 2042581 gatttgatca agcagggtaa tcggatctcc gtcattttca taaacggttt cgtgaatcga 2042641 agatggagcc cttaccgcct cttgggccag tacaacatcc tcagcttcaa tctccaaatg 2042701 gtcagcgatc tcctgcaccg tcggcactct gcccagtgtt ttcgaaagct catccttcgc 2042761 gcgccggatt ttgtttccaa gctcttttaa tgaccgtgat acctttacgg ttccgtcatc 2042821 acggataaat cgttggattt ctccgataat catcggcact gcatacgttg aaaaacgcac 2042881 atcataggtt aaatcaaatt tgtcaacaga ttttaacagc ccgatgcagc cgatctggaa 2042941 gagatcgtca ggctcatatc ctctgtttaa aaaccgctgt acgacagacc aaacaagacg 2043001 catgtttttt tctatgagga ggtctcttgc ctgctggtcg ccattttggc tttgtttgat 2043061 taattccttt acttcatgat ccttcagctg agcgtttttg ccgtttttct taacctccac 2043121 atccataaca aatctcctta attacaaagc gctttgcttt ttgataagtg ctttgttaag 2043181 cgaatcgttg ttcccatttc aggcgatgaa tcgatactga catcatccat gaaattttcc 2043241 ataatggtaa agcccattcc agagcgctca agctcaggct tagtcgtaaa tagaggctga 2043301 cgggcttctt caagatctgt aatgcctaag ccttcatcac gaatagtcat atatacgaca 2043361 tgatcttcca gcgtcactga aatgtaaact ttcccttcac agttctcttc atatccatgg 2043421 ataatcgcat tcgtgacagc ctctgacacg actgttttga tttcagtcag ttcatccatt 2043481 gtcgggtcca gctgagctat aaatgaagca actgtcacac gggcgaacga ttcattctga 2043541 ctgagggcag aaaactcaag gtgcatttca tttttcatga tgccaccccc agtgtcagga 2043601 gtgcctgctg ttcagattgt tcaaatcgga taattttaaa cagacccgac atatcaaaca 2043661 atcgcttcac cgcaggagag atagcgcaaa caaccatttc tccgccaatt tgcttaattt 2043721 gcttgtatct tcctaaaata acgccaagcc ccgagctgtc cataaaggaa aggtcctcca 2043781 agttcagcac gatatggcga atatcatcct tctccaatga ttgagtcact ttttgcttca 2043841 gggtttcagc cgtatggtga tcgagttcgc ctgttaatcg aatacaaagc acagattctt 2043901 tgacattcat gtcaattcca aggctcatgc tcattcctcc ttgatatgat cggataatga 2043961 gtgtttcgat ttcgacggaa tgaattcctt caccgtgaca aaactagtgg tcattcggca 2044021 taattactta aattttgtcc agtctcccat cgtccgcttt aagaatgtga taaacccggc 2044081 tttcttcata tcttcttttg cagcaacagg actttcagcg agtacttctc catccttttt 2044141 cagaacaaga gtgccaagct cttggccttt ttgaatcgga gcactaatat tgtccttcat 2044201 cttgatttct tttttcacat cgttcatatc ctcgcctttt ttcgtcaata ttgaaatcgg 2044261 ctcagatgta gtgagttcga taaatttttg tttccctttt ttgaccttta cttttgctac 2044321 tgtttgattt cgtttatata aaggatgcgt ttcatattgg ctaaaggcga agtcaagcat 2044381 ttttgtcact tgcgcgtttc tttctttagg cgtgctcgct ccgaatacaa ccgctatggc 2044441 ccgcatgttt ccttttttag ccgaagcagt cagacaatat ttcgcttcgc ctgtatagcc 2044501 tgtttttacg ccgtctacac caggataaaa tttgataagg cgatttgtat ttacaagcca 2044561 aaacttttta tctgtatttt cacgcagata atcttcatac gtgccggtaa acttcgtaat 2044621 tgattcgtat ttcaataatt ccttagccat gattgccatg tcataagcag agctgtagtg 2044681 tccttcctcg gtcagtcctg ttgggttttt aaaggatgta tttttcaatc ccagctcttt 2044741 tgctttttta ttcattttct tcacaaattc ttcttcagag ccggaaataa attcagccat 2044801 ggcgacggaa gcgtcatttc ccgaagcgat tgcgatgcct ttcagcattt ctttgacagt 2044861 catttcttcg ccgggctcaa ggaatatctg tgagccgccc attgacgccg catgctcgct 2044921 tgtacggacc ttatcactca ttttgatttt gcctttatct aaagcttcca taatcaaaag 2044981 catcgtcata attttcgtca tgcttgcagg cgccagtctc tcattgctgt tcttgttgta 2045041 aagcactttt cccgtgtcac gttctatcag caccgcagac ttcgcttcat gagcaagctc 2045101 cgatgtacgt tttccgtctt gttttgcaaa tgcagacggt gcaaatgtaa gcagcattat 2045161 accaatcaac aaagtggata aaagacgttt catctcaaaa gccctccatt tcataatcct 2045221 ttttattttt tccaagcgtg atggttttat acgccactga tggaaaatgt ttcgaatttt 2045281 gggcataaaa aaagacagct gtgtgatatc agacacagct gtcttttggt cctgcattga 2045341 ttcatattta ttcgtactga gcgacgatcg ctttaacaag ctttaagaat ccagctttta 2045401 ctttttcggt cacttccata acttcatcgt gacttaaagg ctgatccaga attccggctg 2045461 ccgcgttaga gatgcaggaa atgccaagaa cccgcattcc cgcatgattc gctacaatga 2045521 cttccggaac agtagacatg ccgactgcat cagagcccat cgttcttaag aaacggactt 2045581 ctgccggtgt ttcgtaagaa ggtcctgtca cagcagtgta cacgcctttt tgaattggga 2045641 tattaaggtc tttcgcaatc ttttcagcca ggctggacag atctttgtca taggctgaag 2045701 acatatctgg aaatctggcg ccgaaatctg cttcgtttgg cccgattaac gggtttgttc 2045761 ccataaagtt gatatgatcg gtaataatca ttaaatctcc cgcacggaat tcagtgttga 2045821 caccgcctgc ggcatttgtc acgatcaacg cttccacacc gagcgctttc atcacgcgta 2045881 cagggaatgt gactttctcc attgagtagc cttcataaaa atgaaagcgg ccctgcattg 2045941 caatgacgga aactccttca agagtgccaa gcacaagctg tccggcatgc ccttcaacag 2046001 tagataccgg gaattcaggt atatcttcat atttcagctt gaccggattt tcgatttcgt 2046061 ccgccaaaat gccaagacct gagcctaaaa taaggccgat ctttggagat tccggcaggt 2046121 tttgtttaat aaaagcggct gcgcgttcaa ttctgtcctt caagaaacag tccccctatt 2046181 gtaataaaga taaaaagctt ttcccgtatt tcggtttatt tgtttggaaa ttatcagcga 2046241 tcgttgcgcc aatatcggca aatgtatctg caagcggcag catttgcgct ttcttatgtt 2046301 ttttgctgta agcgagaatc ggcacatact cgcgtgtatg gtcagtccca tgatgaatcg 2046361 gatcattgcc gtggtcggct gtaataatta acagatcgtc ttctctcatt ttttcaaaca 2046421 cttccggaag ccgcgcatca aattcttcaa gcgcgcgtcc gtagccttca gggtcacggc 2046481 ggtgtccgaa taacgcgtca aaatcaacaa ggttcgcaaa gctcagaccc gtaaaatctt 2046541 ctcccagcgt atcgatcacc ttgtccattc cgtccatatt agaaaccgtt ctgcgtgaag 2046601 aagtaatgcc ttctccgtcg taaatatcag agattttacc gattgaaatc acatctaagc 2046661 cgcagtcttt caattcattc atgacagtgc ggtcaaacgg cttcagcgca taatcatggc 2046721 ggtttggcgt ccgtttgaat tgacccggct ctccgacgaa cggccgtgca ataatgcggc 2046781 caaccatata tttcggatca agcgtcagct ctctcgccgt ttcgcaaatg cgatacagct 2046841 cctcaagcgg cacaacctct tcgtgagcgg caatttgcag aacagagtca gcagacgtgt 2046901 aaacaattaa agcccctgtc tccatgtgct cctggccaag ctcatccaaa atcgctgtgc 2046961 cggaagccgg cttgtttcca ataattttgc ggccagatct cttttccagc tcttgaagca 2047021 attcatcagg aaagccttcc gggaacactt taaacggttt atcaatgtat aaacccataa 2047081 tctcccaatg gccggtcatc gtatctttgc cgtttgacgc ttcttgcatt tttccataat 2047141 aggcaagcgg atgttctgtt ttttctacac ctttgatatc ttcgataaga ccaaggccga 2047201 gctttgccat attcggcata tgtaatccgt tcatatgctc ggcaatatga ccgagcgtat 2047261 gagcgccttc gtcattaaag tcagcggcat ccggcgcttc gccgattccg actgagtcca 2047321 tcacaattaa aaacacacga ttatatttgt atgcaggcat cttgaaagcc tccttttttt 2047381 ctatacgtct attgtatcgc taagaggtct gacaactcaa gtataaaccg ttttcattcc 2047441 cgttgacaat gtatttggaa ataatgagaa acttcaatat tttctgtcgc tctaaacaaa 2047501 aaagccgcag ccacctgcgg ctatgctcgc ggatgaaact gcttgtacac atccttcagc 2047561 cttgttttcg tcacatgcgt ataaatttgc gtcgtggata tatccgcatg accgagcatt 2047621 tcctgcaccg ctcttaaatc tgccccgttc tcaagcagat gcgtcgcaaa ggaatgcctg 2047681 agtgtatgcg gagtcagctc tttcttaatg ccggcttcca atgcgatttt tttcaggttc 2047741 ttccaaaatc cctggcggct gatctgtttg ccgtgatgat ttaaaaagag ggcgtcagat 2047801 acattatttt ttaacagttt tcccctggct tttgtcatat attcctcaat ggcggaagca 2047861 gcggcttcac cgattggcac aatccgttct tttcttcctt tgccgaagca tcggataaac 2047921 cccatagata aatgaacatc agccgttttc aattcaatca tttcactgac tcgtatgcct 2047981 gtcgcataaa gcagctccag cattgcttta tcccgatatc cgaaagggct cgtcagctta 2048041 ggcgtgtcca ataaccgctc gacttcattg agcgcgagca ccttcggaag cgcccgttcc 2048101 gtcttttgtg tttcgatatg aacggaaggg tccttatccg ttactttttc cctgagcaga 2048161 aattgatgaa aagagcgaat ggatgccaaa tgccgcgccg atgtcttgcc ggatttcccc 2048221 gagtccttca aatgctttaa gtattggata atatgtatgc gggtaacgtg attccaatct 2048281 gtaacatgaa gggtttctgt taagtagaga gaatagcttt tcaagtcacg ttcataggat 2048341 acgatcgtat tttgagagag ccctctctct accataacgt agtggatgaa atcctttatt 2048401 tgatctttca ctcttgatct actccccgtt ttggtaaaaa aagatcaacc ggtcgaacca 2048461 tccgcctttt tcatcctgat ccatttcaac aacttttaca gcggagcctt ccggtttatc 2048521 ataccgatga tagttttcat actcttgatt cacccatatc atagcataat agaacaaagc 2048581 ggtaaaaccg gtaaacagga tgaaaacttt caatgcatcg acagctgttt tcaggaatct 2048641 tcccatgtcc taatcgatcc tttccctatg gttccagtta tataaaccat atgccaaatc 2048701 agaaaggttt tatacataga aacagcaaaa aaccctttcc ccatgagaaa aggttcgcgc 2048761 tcggcaccgt ctattcagtt tcttttccgt tacagcggtg gcaaatgccg tgaaacgtca 2048821 atctatgatc tttaatctta aatttccaat cacgttcaat gatttcttcc acgtcttcaa 2048881 gcaaatcttc ttcaatttca tcaacggctc cgcactccat gcacaccaag tggtgatgaa 2048941 agtgagctgc gccctctttc cgaaggtcgt aacgggacac accgtctcca aagttaattt 2049001 tatctacgac ttttaattca gttaataatt caagcgtacg gtatactgta gcgagaccga 2049061 tctcaggaga tttctctttt acgaggaggt atacatcttc tgcgcttaaa tggtcttctt 2049121 cgttttcaag cagcactctt actgtcgctt cacgctgtgg cgtaagttta tagctggatg 2049181 agtgcagttg tttcttaata cgatcaatac ggttttccat gtctttccct cctacgccgc 2049241 attccatgac tcattataac aaaatacgcg cagagttcca actataatta ttataaactg 2049301 ataaataaaa tggttttctt ttaataatga ttttaaaaaa gtctagatgt aagcttttcc 2049361 attaaaacag gagataagta tgcttcaaag agagatgaaa tcagcgctaa aaacagaatg 2049421 accagcagca caaaggcata ccgcccgaac cattgaatcg gcgcgtcatg caggcttcgt 2049481 ttcacgaaca gctgtctgat taactttaaa gaaaacgcaa ttgcacatgt gcccataatg 2049541 agataagccg gaatcagcag cacattttgc ggcaaaacgg agacaaatga taggaaaaac 2049601 ccgcttactc ccatctgatt gactaggaac ccgacagtaa agccgacgac gatccctttc 2049661 agaaagatca taatgaaaat aatcggcatc ccaatgacgg aaattcccag tatccacatc 2049721 aggcctaaat actttgcatt atgaaagata ctttgcccaa acatatcagc tgaacttgcc 2049781 tgttttccat ccgaaagctg tccaaaaaat tgacttaagt agtagtataa atcttctttc 2049841 tggctgatgg tcatactgtt gacaataatc gcgccaaaga tgacacccat gaaaaacagc 2049901 actgacacaa atatataaag agagagatga tctttgacat gcctgagaaa catgtcctta 2049961 taagagattt ttcgcatacc gtttcctccc gcccgctcta gtgatttgat ttaatagatt 2050021 gtatgaaaga aacagaaaaa catgcccttt ttcaaaaaga aacaatagag atgaatgcta 2050081 ggcggctttt tggggcacaa aaaaatcctt atcatcaact gctgtatgat cataaggatt 2050141 cttatgcttc cgtttattca aaatctcttt tttgcttttt gtcattcttc catgtgtgct 2050201 gaaagatggt gtgctgcctc ttgataataa gacgtcacgt ccgccgtttc tcaatcgatg 2050261 cccccgcttc tttttcgctt ggctttttgc catgtgatca ctcccttttt tattttcata 2050321 gtaatgataa caaaattgaa caatgataag aaaaaaacag cacctgctac gacaggtgct 2050381 gtttagctac atttatttca ctgctgtaag agctgcatgc tcgacagctg ctgctaccgc 2050441 atgatggact tttgaatcaa gcggctgagg gacaacatca ccttgtttag tgcaagctgc 2050501 gatggcctct gctgctgcga caagcatatc atgattaatc tccgtgcttt ttgcgttaag 2050561 cgctcctcta aaaatccctg gaaaaccgag tacattatta acagaacgcc cgtcagctgc 2050621 atatgcggcg ccagcctgca gtgcggcctc cggctcaatt tccggcttcg gattcgataa 2050681 agccagaatc acttgaccag aacgtacaaa tgccggtttt attaaacccg gaacgcccgt 2050741 tgtagcaatg acaatatcac atgtttccat aagctcctca atactggaaa ctgcctgtcc 2050801 gccgtattgt tcgagacggt tcattgctga ctctgatttg tctgttccgt atacagcatt 2050861 cacaccataa gccatgaaca tccggcagat ggccacgcct gctgcgccaa ggccgatttg 2050921 ccccactttc gcttccttca ggtcaacccc cgcactcctg catgccgaaa tggcagctgc 2050981 cagcgtcact acagctgtac catgctggtc atcgtgcata acagggatgt tcagctcctc 2051041 ttttaggcga tcctcgattt caaaacaatg cggcgaaccg atatcctcaa gaaggatgcc 2051101 gctaaagccc ggagaaatat gttttactgt tttgatgatt tcttcaggat cactcgtatc 2051161 aagcagtatc ggaatgccgc taatacccgc cagctgatca aataaagcag cctttccttc 2051221 catgacaggc atgccagcca cagagccgat attcccaagg cctaaaattg cggttccatc 2051281 cgttacaatt gcaacagaat tgctgatcgt tgtataaata gaagcttttt caggttcttt 2051341 ttcgatcagt cggcacacgt ccgcaacacc tggtgtgtag acacgtccca gctctgccag 2051401 tgaacggatc ggcattttgc ttttcatttg gatttttccg ccttcatgtg cggacaggac 2051461 ttcatcagat acggtgtgaa gcctgatccc ttctccgagg gcctgtacag ccgcgatcac 2051521 ttcctgaagc tgttcttcat tctccacttg aacggtaata ttccgcattg tgtaattggg 2051581 tccgactttt accgtctcca cttcaccaat atccccgccc agaaggccga tggccgtagc 2051641 cacccttcca agatttccgg gaaccgaagg cgtttcgatc atcagtgtcc gaatcatgtg 2051701 tttcgctatc attcagtgat cctcccctat tagcctagtt tttcggcttt aactgtattg 2051761 tttttcgtat accatataaa ttttcctgta taaccataga taattgcaag acctattgct 2051821 acaaaactga gccacataaa cggcagataa gagaaggtag aaacacctaa aataccagcc 2051881 atgtaaatcc cattatcaga ccaaggaacc atccccgaag tcaatgttcc cccgacctct 2051941 gagttacgtg ataacactct tctgtccaga tgtaagcgat catagctgtc ttccataatt 2052001 ttcggagtca aaataagaga tacatacatc gcacagccga agatgtttgc taaaaacgct 2052061 acgatcagtg tagacaatgt gacattgccg gctgaagtta atttcttttc aaacgttgaa 2052121 acaatgactt ttaacacgcc gagtttctca agcagaccgc caaaaccaag gccaaagatg 2052181 atgacgacga gagaatcaag cataccgaca attccaccgc ggtttaacaa gccgttcaaa 2052241 aattcaacat ccgttttaat agagaagccg ttgtacgcag ttgcaatcgc atgggcaata 2052301 tccattcctt ggaaaacaac agcccagatt gcaccgagta aagcgccaat tacgataact 2052361 ggcatagatg gctttttcat cgccaataag actatgacga gaactgccgg gatcagcatc 2052421 caaatatgaa tgtcaaacgt gttttgcaaa gatgatttta agaattcaac tttatcaaga 2052481 tcaatatttt tcccgccgta cataaatcca acaactgtaa agagtatagc tgtaatgaca 2052541 taagcaggta ttgataaata aagcattgct ctcacgtgag ccaatacatc gacttttgat 2052601 agtgaagaag ctagaactgt actgtcagac agcggagaca gcttgtcccc aaaataagca 2052661 cctgaaagaa tagctcccgc tactagagga agcggaatgc ctaacccctc tccaattgcg 2052721 atcatggcaa tgccggcagt tccgactgtt ccccatgacg ttcctgttgc cacagacata 2052781 atggaacaaa taattaacgt tgccagtaaa aagatacttg ggtgaataaa ttccagtccg 2052841 taataaatca aagtcggcac aacgcctccg gcaatccatg ttccgatgag cgccccaact 2052901 gaaacgagaa tcagtacggc ttcaaggcca tttgatatcc catgtacaat cgcattttgt 2052961 aaatctttat aagaataacc gagtctaata cctaaaagca ttgcaataaa ccatgaaaca 2053021 aaaagcgcca gctgtatcgg caagtcgaga aagactgtaa acgatagaac aagtgctaaa 2053081 aatactccta gtacaataat aatttcaaat agtgttggca atcttacatc cttcaaaaga 2053141 agtccccctt catgtaaaag ctaaaacgct ttcaatatat agtgcaacac gtatactata 2053201 cttcctcatc cctatgttgt aaacagctta ttcatccgac tattcggaga tgaataagct 2053261 gtattttata caaattttat ttttctaata gttctttccc tgcgatacct ggtttggtca 2053321 tctcatatgg gtttaaaata atatccaatt cttcttcagt cagcacatca tgctgcagac 2053381 aaagatcccg gacagattgc cctgtcataa ttgcttccct ggcaattcta gctgccgctt 2053441 catacccaag atgcggattg acagctgtga tcacgcctgc gcttttttct acgtattgct 2053501 tcatacgctt ttcgttggct tcaatgcctt ttaagcagtt gtcagtgaac gaacggaagc 2053561 cgttgttcat gatgctgatg gattgaagca aattaaagac aagcacgggc tccatgacgt 2053621 tcaactcaag ctggccggct tctgaagcaa ggcagattgt attgtcattt ccgataacct 2053681 ggaacgcaat ttggttgatc agctccgcca taaccggatt gactttcccc ggcataatag 2053741 atgaacccgg ctgacgtgca ggcagagaaa tttccgcaag tccggcgcgc ggtcccgacg 2053801 ccattaagcg caggtcgttt gcgatcttcg acatgttcat catgcagact tttaatgaag 2053861 ctgatacctc tgtataggca tctgtatttt gtgtcgcatc aacaagatga tcagcgccga 2053921 caagaggaag cccgctaata tcagcaaggt gctttactac ctgtttgata tattcaggat 2053981 cagcgttcag ccctgtacca acagcagttg cgcccatgtt gacttcatac aggtgctggc 2054041 gcgattgctt gattcgtttg atatcacgct cgagaacacg gctgtaagct tcgaattcct 2054101 ggccaagacg gatcggaacc gcatcttgaa ggtgtgtccg gcccatttta ataacagagt 2054161 caaactcctg tgctttttgc ttaaacacac tatgcatatc ttccattgtt ttcagcagtt 2054221 tttctaagag cttcaatgtg gaaatatgga tagcagtcgg gaacacatcg ttcgtagact 2054281 gtgacatgtt cacatgtgtg tttggactta aatggatata atctcccttt ttatgtccca 2054341 tgatttcaag cgcccggttt ccgataacct cattcgcgtt catgttcata gaagttccgg 2054401 caccgccctg aatcggatcg acgataaact gatcgtgcca cttgccttcc agaatctcgt 2054461 cagcggcttg tacgatagct tggccaattc cttcatacag ccgtttcacg tccatgttgg 2054521 caagagccgc agcttttttc acaatcgcca gtgcgttaat catttcctca tggattttgt 2054581 atcctgtgat cggaaaattt tcagaagcac ggagcgtctg aattccgtaa taaacatctg 2054641 cttcaatttg tttttcccca aggaagtctt tttccacgcg atattctttt tggccgttta 2054701 acataatctt taaccttctt tctctttgct ggttatcgtt tttacatttt acaggacaac 2054761 gtcatcagct atcggcgttt ccataattct cttgacgaca ggaagatccg aagactgacc 2054821 tagcgcccac atcaattttg gcacaattgc ttctgtgttc atatttcttg atcggataat 2054881 taagtcttgg ttgactctgc ggccaacctc gtaaatgctc atgtcttcgc cttcttcaag 2054941 acattgagtc gtaatgacga cgacaatgcc gctttcgatc agttcattca cttttgacaa 2055001 aatgtctctg ccttcaaacg gcactcctcc gctgccataa ctctcaatga caattccttt 2055061 gtacatgctt ttcagggcat caaacatttc gggctttaag cctggatgca gcttcagcag 2055121 acatacatct gtgcatagtg aagtgtcaac tgtgaaggtg tcgttctcag gttccgttac 2055181 ttgtttgttg tattcgatcc cgtcttcatt gataaaagcg atatatgggt aattgatgct 2055241 ttcaaatgcg tcgtagcttt tcgttcttaa tttgatcgca cgcgttccct gaatgactct 2055301 gccgtcaaac acaacataaa cgccgcccac gccttcacag gcaaatcgaa tggcatctgt 2055361 aatatttttt ttggcatcgg ttttttggaa cgtgatcgga atctgcgagc cggtgatgac 2055421 aatcggcttt ttggcatgct gcagcatata cgatagtgcg gcagatgtat aggccattgt 2055481 atctgtaccg tgagtaataa caaacccgtc ataggcatca taattttcct taacggcttc 2055541 tgctatttcc acccagtatt caggctgcat attggtgctg tctatattca taagcgactg 2055601 agtttccatt gtgtaatcgt tatcaagttt tgatacgtaa cttaataatt catcagcctt 2055661 gactccggga gccagcccat tttccccttc aactgaagca atcgttcccc cagttgtcaa 2055721 catcaataat tttttcatac catgcacctc ttcactgtat ctaaagatgg gttgcgagaa 2055781 ggtattcgct tttcgcatac ttttaatgca attatagaca cggaaaataa aatacgcaag 2055841 acattattat tcaattcgcg tacacttcct aatacctata tgatataatc agctcaaggt 2055901 gaaaaaggag cggaagttca tgaatctaga tcgtttaact gaattgagaa aaaagaaaaa 2055961 ttggtcgctt caatatacag ctgaccttct cggtatcgca aaaagcacat atgccggcta 2056021 cgagtcaggc taccgacggc cttcacttga agcgcttgcc atgctggctg acctctttga 2056081 cacaacctgc gatgaacttt taggccgcga gaaacaaaag cagactgctc ctcaggccat 2056141 agaattggcc acgtggagca gcctcgactt taccatttct gttgatggcc agccgctgag 2056201 tgaagatgaa atcatccagc tgattacctt tatacgcaca aaaagaaaag tacaggagga 2056261 actgagttaa tctttagctc acggtttaat tttaccgtag gttcctcctc ctccggcttt 2056321 caattccagt tttccggatc tcgcttttac gataagcgcc gcggttttcg gcgggacaac 2056381 gcgagccaaa tcttcttctg cagcctcatg aagaacagcc atttctgttc cgaaggcttt 2056441 ttttagtttg tccagcgttt tcgggcctac acccggaaca aattgcagcg ggatctgatg 2056501 tacatatcgc ggacgcggga cgcgaacttc aagctgatca ctcaattcac gcaatctatc 2056561 gctgactccc ttggtaaatc tggcttttcc gcaattcgcg cacgctgttt ccccgcttac 2056621 agcaggctct ccgcacgctt cgcaagccgt ctgataatat ttccccaata acgggtccaa 2056681 gccataattt gcgataattt tcctgtcatc ttgtcccttt aatgcaagag caaattcagt 2056741 aaaatcagct gactgcacat ataattcatt atattctctg ccgattttcc ccaacgaatg 2056801 cgcatcagaa tttgttaaaa aaggatacgg attcaattgc gatacgtgtg atgccatgtc 2056861 tgtatcacag cttaatccaa gctccaccgc gtctatcata gatggatcaa aaacctcagt 2056921 taagcttgat ttaacccctt ttccatataa gcttttatgc ggcgtaaaga tatgggcggg 2056981 gataaacagg ccgcccatat cctgcacttt tttttgcagg tttaagcccg tttcataaat 2057041 ccgctgcgag cttaaatgaa tatttttcag ccgggctgac agccagtttg aaaactgttt 2057101 catatcagcc agcgtcggca taaatacgag cacatggatc ggtccgctgc aggcttcatc 2057161 ataaatctcc agctcgctcc ccaataaaag agtcgtgctg cgataacgga ttcctccccc 2057221 gtcaagctcg cgatattttc cagatgaaat gccttcctca agctctagaa tgacttccgg 2057281 agaatgacag tcgataatgc cgaggagttc aattccttta tgttcactgg cttcaaccaa 2057341 aattctgtcc agcgttaatg ttttggcgcc tgttattttg acagcccttc ctgtaaaggt 2057401 ccggccgata tgaatgtgca aatccgcgta aatctttttc atttttgtgc ttggagcgct 2057461 tctttcagct gaagatactg aatcgcgtag gctgttttag catcatatac ttcacgcgat 2057521 tcaaccagct ttagcgcatc ttcaagcgtc acctccatca cttcaacaaa ctcgtcctca 2057581 tcaagctccc gtttttcttc aagcacagaa agctcctcag caagaaaaac gtgaacgatt 2057641 tcatctgcaa atccgggtga tgtataaaac gcagttattt ttgtcagttt ttttgctgta 2057701 taaccggttt cctcttcaag ttcccgaagt gccgtatact ccggctcctc acctttttca 2057761 agcttaccgg ccggaatttc aacgatcgtc cgctcaagcg gcttacggaa ttgtttgacc 2057821 atgatgattt tcccttcatc tgtgacggct agtaccgcta cagctccagg gtgtttcaca 2057881 atttcacgtt tactggcttt gccgtttggc agctctacat cctcgacata aagatcaatg 2057941 actttacccg aaaaaatctg ttctttggca attgtttttt cttctaatga tttcatttct 2058001 tcatctcccg ttctgtctct atatgatgcc ccatacattt tatcatacta gagcaaaagg 2058061 gggcttcttc gtgaaagtgc accgcatgcc aaaaggtgtt gtcttagtcg gaaaagcatg 2058121 ggaaattcga gcgaagttaa aagagtatgg acgcacattt caatatgtga aagattggat 2058181 ctcaaagcca taaaagttga aactttagct cctttatatt acggtcaata caaagcctaa 2058241 aaaaggagtg tgcacatgag aaagcgcaaa ttgggtacat ctgatttaga cattagcgaa 2058301 gtcggactcg gctgtatgtc tcttggaact gaaaaaaaca aagcattgtc cattctggat 2058361 gaagcgatcg agcttggcat caactatttg gacacagcgg atttgtatga ccggggacgc 2058421 aatgaagaaa ttgtcggtga tgcgatccaa aacagacgcc atgatattat tctggcaaca 2058481 aaagcgggaa accgttggga tgacggaagc gagggctggt attgggaccc ttcaaaagct 2058541 tacataaaag aggcggtaaa aaagagcctt acacgtctga aaacagatta tatcgacctt 2058601 tatcagctcc acggcggcac gatagaggac aacattgatg aaacgattga agcgtttgag 2058661 gaattaaaac aagaaggtgt catccgctac tacggcattt cttccatccg cccgaatgtg 2058721 attaaagaat atgtaaaaaa atcaaacatc gtcagcatta tgatgcaatt cagcctgttt 2058781 gacagacgcc ctgaggaatg gctcccgctt ttagaggaac atcaaatcag cgtagtcgcc 2058841 agaggtcctg ttgccaaagg gctcttaact gaaaaaccgc ttgatcaagc ttcagaaagt 2058901 atgaaacaaa acgggtactt gtcctattca ttcgaggaac tgacaaatgc ccgtaaggca 2058961 atggaggaag tggctcccga tctttccatg acagaaaagt cgctgcagta tctgctagca 2059021 cagccggctg tcgcttcagt gattacaggc gccagtaaga ttgagcagtt acgggaaaat 2059081 attcaggcag caaatgcacg gcgtttaacc gaagaggaaa tcaaagcgct ccaatctcat 2059141 acgaaacaag acatttacaa agctcatcgc tcatagcaga aaaaccagca cctgtacggg 2059201 tgctggttta tttatattga tgccaatcca tttggctttc atttaggagt tcttcaaagc 2059261 tcttattttt ttcgatctct tttttctttc taatctgttc tgctttttct cttttctgcc 2059321 tcttttcatc ctcttccttc aattggctct tcatctccat aagctttgct ttgatatcgg 2059381 attgaaggcc gtcttttagc tggtgtttgt caatggattt ttgttttttc atgcagactt 2059441 cccccatgtt ttgttttgaa gccagtttat cacggagcat ataaactgaa caagcagact 2059501 ctcttctgat cactttctca gcgtagcagt gtttaggtat aatgatctta aacacgaatt 2059561 gcctatatat ttcgttgaaa ggtgctgtga cttttgaaga aaatcctttt ggccattggc 2059621 gcgctcgtaa cagctgtcat cgcaatcgga attgtttttt cacatatgat tctattcatc 2059681 aagaaaaaaa cggatgaaga cattatcaaa agagagacag acaacggaca tgatgtgttt 2059741 gaatcatttg aacaaatgga gaaaaccgct tttgtgatac cctccgctta cgggtacgac 2059801 ataaaaggat accatgtcgc accgcatgac acaccaaata ccatcatcat ctgccacggg 2059861 gtgacgatga atgtactgaa ttctcttaag tatatgcatt tatttctaga tctcggctgg 2059921 aatgtgctca tttatgacca tcgccggcat ggccaaagcg gcggaaagac gaccagctac 2059981 gggttttacg aaaaggatga tctcaataag gttgtcagct tgctcaaaaa caaaacaaat 2060041 catcgcggat tgatcggaat tcatggtgag tcgatggggg ccgtgaccgc cctgctttat 2060101 gctggtgcac actgcagcga tggcgctgat ttttatattg ccgattgtcc gttcgcatgt 2060161 tttgatgaac agcttgccta tcggctgaga gcggaataca ggctcccgtc ttggcccctg 2060221 cttcctatcg ccgacttctt tttgaagctg aggggaggct atcgcgcacg tgaagtatct 2060281 ccgcttgctg tcattgataa aattgaaaag ccggtcctct ttattcacag taaggatgat 2060341 gactacattc ctgtttcttc aaccgagcgg ctttatgaaa agaaacgcgg tccgaaagcg 2060401 ctgtacattg ccgagaacgg tgaacacgcc atgtcatata ccaaaaatcg gcatacgtac 2060461 cgaaaaacag tgcaggagtt tttagacaac atgaatgatt caacagaata aaaaagcgaa 2060521 aggcctcttc ggctctttcg cttttttatg ttacagaacg tcggtaatgc catccatatt 2060581 ttctctgatc cattcaatcg caagatctat cgttgtaaac tcctgcgtct cgaaggtcat 2060641 ttcatcctgc aatagccaga catctttctt gatggactct gctcctccga ttgaccagtg 2060701 aagcaaggta taaggatggt tttgattcag gaaggatacc cacgttttat tttgtgctgt 2060761 gttcttcatt gccttcagct tttgttccac gtttcgcgtc tcctacttta ctaatatgct 2060821 cattctgggg ctgagcattt cagccgggct tttcagcgcc aatgttttgg ctttttcatt 2060881 gtaatcgatc gtcatttgat cgtcaaaaaa cactttttgc gacgattgga tatacagcgg 2060941 aatgccgttc gtttccagct gctcgcactg tcccgttaat tcttctgcca gccagattgt 2061001 cgggacaccg cttaccgcgc agccgcatcc ttctgcatcg taacgaagct gggctttttt 2061061 tcccgggttg gcgtcaaacg cctgctgcag tgcctgtttt gctgcatctg tcacatgtat 2061121 gttcataagg tgaaaccccc gttttcatca ttttcgctat tgtagcatac aatactgcca 2061181 ttcgcattgt ttctgccttt tttccaccgc ttcgcatttt cttctgcagt cttgatccac 2061241 tcatctttcc cttgtatata ctgattgatg ctgtcagggt gctgggccgc cagctgtttt 2061301 ttgagaacgg cgtattcttt cgctatgttt ggatgagctc tgagataatc tctgaataac 2061361 agatgccttt caatagcagg gtttccctgt tcgtacatat ggacatgatg agtgcgttta 2061421 tttccgccct tttggaaata acgcctgccc gctataccgt tctcaccttt tggtgtatag 2061481 ccgttggcct tcatttgttc atcaaattgg ctcacggctt caatgcttct gacttcaatt 2061541 aacatatcaa tgattggctt cgctgccatg ttaggtattg atgtgcttcc gatgtgatga 2061601 atagcgataa tctccggccc gaacacaagt ttcagccgtt ctttttcttc atcgaaacat 2061661 tctgcccatt tttcgttgta gagaatgatc tcaacttttc ttttcggata caaatgaaag 2061721 accgacagca atagaccctg cgctgctttg acggtttctg ccttttggaa tccggcctgt 2061781 gtatagagtg acacagccgg ggtattgttc tcggctgtga ctacttcgat tttctcagcg 2061841 tcttcattat gatcaatgac aaattgcaga agcgctcgtc caattccttt tctgaaaccg 2061901 tcaggatgca caacaagcct gcaaatggtg agataatgca tgtttttctc atatgaaatg 2061961 acaccgatca gcttgccgtt tttccgatat cccgcaaacc gttcatggga tgcttgaata 2062021 tcctttacct tctcttgtaa agcgggaata ccgtcaaaac cgataatctc tgtttccttt 2062081 atgtaggcgg ggatctgtac ggctaaaatc tcacgcgcta tagtggcttc cttatgctgg 2062141 agaaattcaa tcattcgtgt tctcctgaaa cagccgctgt ctgtcgactt ttgcgacgcg 2062201 gactgcatac gactcgtacc aaacgcttct tcctttttct tttgctgctt gatgttcagt 2062261 gtgatgcctc caatggttaa ttgcgtccat actgtcccaa taggaaactg tgatgcccct 2062321 tccatccgct tcacgtacgc tttccacgcc taaaaatcca ggctgatccg ccgcaagtga 2062381 taccatccgc tccgctgttt ctccatatcc tgtgtcattt tcgcttttga cagaagaaaa 2062441 aatgactgca tagtaaggag gctcaggtgt ttttgataaa aaatccatca tatttccccc 2062501 tcatatgttt ttgacaaata gtaccctgtc ttggcccggg ccatcatagt ttgcaaacac 2062561 tgagatgcca tttaccgttt tggtgccctt ttcaatatca aaccccaatt ttgtgtgata 2062621 tgcgattgat accttattca caggtgaagt gacacacttc acccgggtgc agcccctttg 2062681 ttttactgtt tcgataaata catcatacaa ttgtttccca atttgcattt ttctgaaatc 2062741 cggatgcaca ccggaaaaat gaatgtacgc cgtttcagga tcggattgcg attgaaatcc 2062801 gattaaaaat cccgtcatgc tgttatgttc ggatgtaata aagcttgtgt cctgaaaatg 2062861 ctcaaaaaat agtctcggca atttttcttt cagctgtctg ccgccccacc attcattcag 2062921 tacagacgtt accatttcat aatctgaaga cgtgattgtt cgaatatcca ttacgatttg 2062981 atctccctcc gtctggcaaa acgaatgtca gctctttttc tcacaatata aaaattatat 2063041 tttgcctggc tggaattgta aatgccttct ttcctgtatc atacgtttcc agactgccga 2063101 gggaacaatg tttgatcatt ttacgcctat ttctccccca aacaggagga gagactttac 2063161 agcacaatat caagcacttg atcaagtttc agcttataaa gctgatcctc gtctcctttt 2063221 atccatactg ctttttcaaa ctcttcatac cggcagattt tcccggtgca gcagacaatc 2063281 tcaccgtcct gaaagcagct gacagtgata tcctgagcaa actccatcgc ggcgcaaagc 2063341 gtttgattca tctcttccag cttatcgggg tcaaggatcg gcttttgcag cttctgttta 2063401 agtcgctttc tctccagcag gctttgctta tgttccggca gaaacatcct gctcccttcc 2063461 cacagcaggt tgcccctttt taaatggtcg ttcatttata atgcccccct attttagccg 2063521 cacgttcaaa tgcctggcct gccgctgtca gtgacgccgc cctgatgatt gctgtatcgc 2063581 cgaatcgatt tttaatgcca tccatcacat agcctaggct cattttcttt gcataatcct 2063641 gaaataaatt gagctgccat atgtcatcag atgagagctg agacagattg acaccgaggc 2063701 ggcggacggg tttcccgtcc caaaatgtaa gaaacagccg tcgtacagcc tcatatacat 2063761 cctgcgtaga attagtcggc tctgccagct tcacttgccg gttgaagccc gtcggccaat 2063821 caaaatcagc accccggcag ctcactgaca ctgtctgccc catgaccccg gcgtttcggc 2063881 ttcgcctgca cacctcttca ctcagctcaa gcaatacgac cttgatttct ttgtcaaagt 2063941 gttcgtagtc tctcgggaga gtcattccat gacctatcgc cttttgcccg tccagagacg 2064001 aagttgacac aggggaatag tcgattccgt ttgccgtcat ccacagcacg tggccgttaa 2064061 tgccccattt cttttttaaa agatcgagcg gaaaagccgc gagcccgccg atcgtgctga 2064121 tgcccattcg atttaaatga tgcttcatgc ggctcccgac gccaaacatg ctgcccaccg 2064181 ggagcggcca catttcggtt ttcatatttt ctttcgttaa ggtaaaaata ccgttcttat 2064241 tctttttggc aaaattgtca cacgcaattt tggccagcgc tttgttaggg ccgattccga 2064301 cccgtgcata aacgccgatc tcccgcatga ttctgccctg aatgcttttc gcgatctcca 2064361 tcggcgtccc aaacagcttc tggctgcctg taatgtccat gaactgttca tcgatggaat 2064421 acggctccac aaggtctgta tactcctcga gaatggccgt aatttgcagt gatacatcaa 2064481 tataccgctg catacgcggc cggagcacaa cagcctcagg acacttttcc tgcgcctccc 2064541 acagccgtga agcattcacc acaccctttt gtttcgccag cgggcaggca gccaatacga 2064601 ctccgcccct tttttcaggg tcacccgaaa caatgacggg cctatttttc aaatgtggat 2064661 tttccgcttt ctctacagat gcataaaacg attgcatgtc aacgagaaaa atcacttttt 2064721 ctttcatcat acacacctct aaaaagaact tatgttcgct tttcattata tgcgaaagta 2064781 tgttcgtttt atactggtaa atgattcttg tctgacagaa aatatgatcc aagggtttga 2064841 gagaagaaaa acatttagta gaataaaagc gaagcataag gataggagag tcatgatgga 2064901 gaaatttgtc gaaaaaatgc tgggacaggc attgcggcaa tacggcagaa acgttgctat 2064961 agatccgtta agcccgtatg aaaaacaaag cctgaaagcg gctctacaag agagacggaa 2065021 tgaagaacca gatgaggatt tgcatgcgca tatagaagat atcatttatg actatgtcac 2065081 aaaccaaggc ctgttctctt aaacgcatga ctgtcagttc tttcagccgc tgatgcggct 2065141 tccctttgaa aacaccgcct gaaacaaata aacagtctca ggcttacaga aaaaaagcag 2065201 gattttctca cgctccatag attcatatgg cctggcgtaa aattcccctc aatgctcgcg 2065261 caaaacggaa taagctgtcc atgatcacgc gtatacactt tttcgaagag atgtgctctc 2065321 ttgttctgtc atgcggtcca tgccggtttt cagcgtacat cttgatctca tagccggttt 2065381 cactgccgat atgatccacg ttctggcggc ttaaactaac acaccctcac tgaccaatcg 2065441 ctttgctttt catcggacat cccgtcattt tccttctttc aagatgtaaa ctccgtcagc 2065501 cacacgcatc ctcaacgcat agtatattgc catccataca atcaggcata ctacatgtca 2065561 ataacgaaat attttgaacg atctattgga gaaggaaatt ttttcatata tgatagagaa 2065621 agatcataca tacaggagag aatataattc atgaagaaat ggaaagatat ccacccgatc 2065681 agctggacaa ttataatcgg aaccattttc ggcagaatgg caacatcgat gagcattcct 2065741 tttttagcga tttatttgac agccgtccaa ggcgcatcag cttcctatgc agggctggtc 2065801 atcgccgcga gctcatcagt cggcatcctc gcaagctttt acggcggata tatctcagat 2065861 aaattcggca gaaaaaacat gatgcttgta tcgattttcg gatggatgct ggtatttgca 2065921 ggctttgcgg cagcatctaa tctctgggtg ttttttgtag taaacgcatt aaacggtctt 2065981 tgcaaatcac tgtttgagcc cgcttcaaag gccttgttgt ctgatatgac agaagaaaaa 2066041 acgagactgc tagtttttaa tttacgctat gcggctatta atatcggcgt tgtcttcgga 2066101 cctgtgcttg gcctatattt cggctcatcg caatcgacta cgcccttttt ggtgcctgca 2066161 gtcatttacg gactatacgg aattgtgctt gccctccaat ttaaaaaaca tccatcctta 2066221 tcagcaccag cccagtcccg aaatatgagc gtgcgggaag cgtttatggt cacgcaaaag 2066281 gattatcttt ttaccattgc tttggtcggc attacgctat gcaccttcgg ctactcacaa 2066341 ttcagttcca cattccctca gtatatggcg cagaacccct tgatcggcaa tggaacgaag 2066401 ctgtatgggc tgatgctgac attaaacgca atcgttgtgt tggcgacgca atttcccatt 2066461 gtccattttg caaaacggtt ttcgccgctt tgttctctga tgctcggtaa tgtgatggtt 2066521 agcatcagca tggccatttt caccgtatca cacggtgttc catcaattgt gatgattgtc 2066581 atcacattta caatcggcga agtgctttta ttctctatga tggatttgta tgtagaccag 2066641 attgcaaaac caggattaaa aggcacttat ttcggggcaa tcggtttttc acagctcgga 2066701 aacgtcatcg gcccttgggt cggggggata tgtatagacc tgtttggcgc tggccggccg 2066761 atttatattt tttctgtcct gagcggcatt accctgctcg gcctgccatt tttagcgttc 2066821 gcctatcggc aaatgaaaat ggagaccaca aaacaccgtt cccgtctgga aaagccgctt 2066881 taaataaaaa acggaagaga atgaatctct cccgcaaaca tgaggtgaag aacatgaata 2066941 taggtgatgt gatgtttcag ctgtttgtat ttattatatt tgccgctgtc gtctttgcgg 2067001 ctgttacagg cttcaagtat gcgaaaaacc gaaaagcgca gctggatcgc attgagaaaa 2067061 agctgaacag cctgtccgaa gatcacgatt aacagcttgg ggcaacgagc tctaccttaa 2067121 tccggtctgg atcctcacaa aagactgcat aatgcccgtc tcctccggca aaaggatgcc 2067181 tgtctcggta caacacacga tagccttttg ccgtcaattt ttcagtcatc tgatcgactt 2067241 gaagcttgga ttcagcatga aatgcgagat ggttcagacc gactcggcat ctatggtatt 2067301 ccggctctag aaatggctct ttcgcctgca caatcactag gtaaaaacga tctttcttcc 2067361 agctgatgcc tgagctccat ttttgatact ctttataacc aagttctttt aagaaccagc 2067421 cccaaaaccg cctagacgcc tccaaatcag agacatacag ttcaatatga tgcacatttc 2067481 ataccctcct taccaacact tcctcgacct tatgcccgtc tcccttacgc aaaatgagat 2067541 ctgacctgaa tttagttggc aaaatatttt catataaatt cggccggttg acactctccc 2067601 aaatcgaggc tgccatctcg tcagcctcct gatcggacaa gtctttaaat ttatgaaaat 2067661 atgaatcagg attttgaaaa gctgtttccc gaagcaggcg aaaacgctct aaataccaag 2067721 tgaaaatccg gctttcctcc gcatccacat aaatcgaaaa atcaaagaaa tcggaaacaa 2067781 aaatacgcgg gttttcccgg tcatcctcca aggtgggcga ctgaagaaca ttaatgcctt 2067841 caataatcac aatatccgcc tgttctacaa cctcgaacac accttcctcg cggtcatagg 2067901 ttagatggga atacaccggg gcctttacgc tgtcctttcc tgattttaag tcattcaaaa 2067961 attcgagcag cgcctttaca tcatagcttt caggaaatcc ttttcttgac atcatatttt 2068021 tctttttcag ctcggcagta ggaaataaaa aaccatctgt cgtgataagg ctcacttttg 2068081 gacggtcagg caaacgcgaa agcagcttct gcaagatccg cgccgtcgtg ctttttccga 2068141 ctgcgacact gccggcaatg ccgataataa acggaatttt ggctgaatgt gggtgcttca 2068201 aaaaaacatt gacatgctta ttgcgttcag ccgcagactt gacatgtaaa tgaagcaagc 2068261 gaacaagcgg aatatagatc gtctccactt cttcaacaga tagataatca ttcaatcctt 2068321 ccacagcttt tgcctcttct tcagatacag caatcgacaa atgcccccca aaaccagacc 2068381 aagactcccg attgtgctgt gtatataaag tatgtaggtt aagttcttta tttttcactg 2068441 tttacacctg actctctgta ggttaaaacc cttacaaaga ttgtaacgga aaaccttttc 2068501 actgtctgct tatttttcat ttcgtttttt tagcaaatca gcaccgattc ggttatacgc 2068561 agccatttca tcttttggaa ccatgcttcc tcccgttccc cagacgacat gtacggcatg 2068621 ttccatctta tatttctgag catagcgcct tccctcttct gtcgaaaaaa gctgaaccgg 2068681 cccgaacatg ccagcaagag cagagggctc taaatattta tcttcagata cagccagcat 2068741 atgaagcaaa gtataaagcg tattgtcctc taccgtataa cagccgctca gaagcggttc 2068801 aatcagcttg ccgacaaatc ctgacggcct ccctacggca agtccgtcag cagccgtctg 2068861 attatccagg ccgatatcct ggacggagat cttctcgtga agtcctgaat aaagccctaa 2068921 cagcatacaa ggtgaatgag ttggttctgc gaaaaacaca tgaacatcat ctccgtataa 2068981 aagcttcagc ccaaatgcta caccgcccgg tcctccgccg actccgcacg gcagatacac 2069041 aaacaagggc gtctcaagac ttggctttat attcatacag tcaagctgtg tttttaatcg 2069101 gcttgcagca acagcatatc ctaagaacag ctgacgagaa tgttcatcat caataaaata 2069161 acagaatgga tcttgttccg cctgccgtct cccttcgttc accgcttcac tgtaatctgt 2069221 ttcgtactcc ataacagtga ctcccttttg gcggaggaga tcctttttcc actgcttagc 2069281 atcggcggac atatgcactg tcacgcgaaa cccgagtgcc gcgccgatga tgccgatgct 2069341 taaacctaga tttcctgtcg aaccgacagc aatcgaatag cgggagaaaa acccggtaaa 2069401 ccgctcttcc tgtaagatgc ggtaatcatc ggtttcctga agcattcctt cttgaagcgc 2069461 gagattttca gcatacttta acacttcata aatcccgccc ctcgctttaa tcgatcctga 2069521 aatcggaagc tcatggtcgc actttaaaag ccatcttccg ggaaatggct gctgatatgc 2069581 cgcttccagc tttcccttca tatgctgcac ctcaaaaagc ggagactcga tgattccttt 2069641 agcgcctttc gtctcaggaa acacctcggc aatgtaaggt gcaaaccgct gcattctttt 2069701 ttccgcttcc gctatctcgg ttgcccactc atctgcacgg ggtaatggcc cctctttctt 2069761 gcctgaattt gcccagaata caggctctgc atcaatcagt ttctgaataa acggatcttt 2069821 aagcagagca tgaaggactt ctgaatgaac tgacattcaa caatctctcc cttccactat 2069881 caaaaactgc cccgtgagaa acaagccact ccaccacagg cagttctatc attatttttt 2069941 catgagcgcg cgtcctgcca gcttttctac aagagctgga aacagctgat acagcttagt 2070001 gccggcattc attaaacgcg gaagattgat ctcccgcttt ttcgtaaaaa ttgcagctgt 2070061 aatttgagct gccacgtcat caggatcaag catccagcgg ccgacatttt tggcgtagtc 2070121 cccgccttta tcagcaatgg aaaaaaagtc cgtctgaatc gggcccgggt tgactgttgt 2070181 cacataaatg ccggttcccg aaagctccat ccgcaaagcg tttgagtaac ctaacacggc 2070241 atgtttggtc gcggaataca ggctagactt cggtgtggcg attttccccg cttgagaggc 2070301 gatattgatg atatgtccct ttttttgctc aagcatttgc ggaagcaccg cttttgtaca 2070361 ggcgatcagg ccgaagacat tcacatcaaa catcgctttc atgtcatcca atgtagagtc 2070421 taaaaccgtt tcaaatatac cgaagcctgc attgttaatc agtacatcaa tcgagccgat 2070481 ctgatcgcgg acccgggcga tatcctctag gcggccgaca tccagaggaa aaatctcaca 2070541 ctgtccgctc cattcctcgg ttattttcct tttgatttct atcaaacgat cctcgcgtct 2070601 agccgacagc aggacatggg ctccttcagc cgcgcataag tatgcgattc tttctccaag 2070661 ccctcctgaa gcgccggtta tccaaatcct ttttcccgct atatgtttca cccatttcac 2070721 ctcttcattg ttttaaagta tacggtattt ccttcccaat atgacgtgat ggcttcttca 2070781 gcctccaaca catcaaggtg acctgccgtt tctgacatcg ttaaaaacaa ttccttttca 2070841 tatacagcag gaaaaagctg ctgacagacc tgaaaagcgg tcatcggctt ttcatccagc 2070901 atgcgacgca catcctccgt cctgttcctc tgcttgtcaa aacgcttctc aatcagcgct 2070961 tgtacactgg tgataggctc gccgtgacca ggaaatacga ttgttggatc aagttgagac 2071021 agccttcgca atgaccgctg ataatccact aaaggctttg acctgacgtc tcccgctttc 2071081 ggcgcttcca aaatcggatt agacgagctg tttgccagca gtagatcgcc gccaagcatc 2071141 cttccgcttt tttcatggaa cagaacaata tgcgattcag catgtccagg catctccaac 2071201 acagaccagc cctcaagccc atctatgccc ataccttctc tgattgattt tgtcagagat 2071261 ctcgtacagg aaaatgcgta cgctgatcga atcagctttt ccgccttccc cgtatcaaat 2071321 ggaacgccta attcaggcag cagcttttga aaaaaacgtt tttgccaatc cataaaggct 2071381 tgattttggc tgatataagg ttcgttgaat gtatgcccaa tcacttcgat ttcatctgaa 2071441 aagacatcaa gcaagcctgc atgatcagca tgatggtgag tcagtacaac ctgctcgata 2071501 tctgacaatt tcacatttac agcggcaagc tgctcttgta aggctctggc agcctctttt 2071561 gtattcggcc cggcatcgat aagtgtcagc gcatcacctt ttacgaggta aacgataaca 2071621 tcgccgacag caaacggtgt cgggacgcgg atcgcaatta catcttcagt tgtcatcctt 2071681 tcgctccttg tcttcattca ttattcatat tttagctttt tctcggtctt gtgtcattat 2071741 tgcagaatga gaacaaacct ttttgaaaaa gctattgaca ttagcttgtc cgccattgca 2071801 taatgaacaa caaactaaaa cgagaaccat tggaacgcta tgacgaggaa tagtatacaa 2071861 ggcaatggcc taagagagcg atacccccgg ctgaaaggtg ttgcggcccg cttgtttgta 2071921 gaacctgccc tcaagtcgcg gttaggaaaa cctaaacgtt tcccgcgtta cggggatttg 2071981 agctgagcac aatttgtgct aatgagggtg gtaccgcgaa ccttttcgtc ctttacgtga 2072041 tgaaaaggtt ttttgttgtt ctaatagaag gaggatatca atgaaaaaga taggatttgt 2072101 cggcgccggg tcaatggcag aagcaatgat caacggcatt ttgcaaagcg gcatcacaaa 2072161 accagaacat atctatatta caaatcgctc aaatgacgag cgtctgattg aattaaagga 2072221 aacgtacagc gtgcgtccat gcagagataa aaatgagttt ttcactcaca ccgatatcat 2072281 tatcctcgct ttcaaaccga aagacgcggc ggaaagcatc gacagcatcc ggccgtatat 2072341 caaggaccag cttgtcattt cagtacttgc aggccttacc atcgaaacca ttcagcatta 2072401 ttttggcaga aagctcgcgg tcattcgcgt catgcctaat acatcagcgg caatcagaaa 2072461 atcagcaacc ggattttccg taagcacgga agcaagcaag aatgatatta ttgccgcaaa 2072521 agctctattg gaaacaatcg gtgatgcaac actggttgag gagcggcatc ttgacgctgt 2072581 cactgcaatc gcaggcagcg gcccggccta tgtgtatcgt tatattgagg cgatggaaaa 2072641 agcagcacaa aaagtaggat tagataaaga aacggcaaaa gcactcattt tgcagacaat 2072701 ggcaggggca acagatatgc tcctccaaag cggcaaacag ccggaaaagc tgcgtaaaga 2072761 aatcaccagt cctgggggca ctacagaggc aggtcttcgc gctttacagg actcccgctt 2072821 tgaagaagca attattcact gtattgaaga aacagctaaa cggagcgcag aaatcaaaga 2072881 acagtttgcc ggtgccgcct tagagagaca ttcttagatg taaggacaaa aacagaaggc 2072941 acagtgcctt ctgtttttta tttttcccgc agcagctggc cggcagattc tgattgcttt 2073001 aatagcgcgg agatcgtaaa tgaaagcaaa tcgggaagca cttcaaagga ataaggcata 2073061 tacaatcttt ccgtccattt atgcgggtct ttaccagccg gaccgacatt taaaactggg 2073121 acatataaag cctgattttt accgcttggc aatgaatacc ctctgttaaa gagcggcata 2073181 ttgcttgtgt atgcatcaac ctcctgtttt tccagctgaa gataactcaa gtccgaaagt 2073241 ccggggaagt actgaacctc ccgtaatgca atgccgtatc gctcagccgc ataatgcttt 2073301 atctgatctg ctgtatttct gatcaattga tcatcctttg aagaaacagc tggataaagc 2073361 ggcggactat aaaacagaac gatgagcggc gcatcctcct tacaaagcga agcaagctca 2073421 gaaacaattt tcgtcgaaaa atccctgtct ccaagctccc ccctgttagc aaaggcataa 2073481 tttagagccc gctctgtttc cgagatcccc gcacgctttt ttgcacgcga gaccagctca 2073541 tcaaatgtca aaacagtgac gtcccgctca atcggctgaa atggctcaaa ttgttgaaaa 2073601 tcctgtgttt tcttccgaac gttcgacatg atttcctccg ccgcctgttc tgctgtttta 2073661 agcagcatct gatgcagctc actagctgag cgtttcattg acagcacatt aaataatgtg 2073721 acggctgtat gcggtgtctg gactgaatat gcctctttca agtccttttg cattaagttt 2073781 accggcggcg gagtgacctc gccatcaacc ttttcgcaat aatcagcatt cagttcaagc 2073841 aaacggttaa tctcagatac cattaaattt gcgtttagac ctgaaaacgg ctctccaaca 2073901 tgtgtctcaa tccccttgca gaaaaaaccc gcaagcacct tgccaatgct tcctgtataa 2073961 aaatattgct gctgatcgcc gggaaatttt tcaaacatcg gttcggcatt caggcaagcg 2074021 gttaatgtga tatcatgctt tttctccatc tccttcaatg caggaaccgc ttcaatcatg 2074081 cctcttgaat tcacttcctc gtccggaacc gttatcaaca gcagattgcc ctcaaaatgc 2074141 ccgttcattg ccctctccag catcgacagt tgaatacaaa gccccgcttt catatccatc 2074201 gtccctcttc cgaacagcca gtctccgctt tcggcatctc ttctcacacg ttccgggagc 2074261 agctcttttt tctctaaaaa ggagctcaaa agctcagcag gcttgcaagc catatgttta 2074321 aattcgccgt aatcttctat gtcaacgaca tcaaaatgac tcagcagaag cactgtcttt 2074381 ttgacattct tctttttgac tagagccgta agaaaagatc tgccatcgtc catcggatga 2074441 agtgttacat catcagggtg cttttgaaaa tagggcttgt ccttcaaaat aaaataaaga 2074501 tactctgcaa gcgctacctc gccctttgaa ccggtgatgc tttcgtattg cacaagagaa 2074561 gttaaaagtg ccagcaattc gtccttcgtc tgccaattca ttgattccgc ccctcctatg 2074621 aataaaaatg cttctatact gaaaaataaa ctgatttctc gtctattata cagaaatgtt 2074681 tgacaaaagc ggttcatttg agcagtttat atgacgggaa agaaatgact tgatataatc 2074741 aatctctaaa aaccttacgg gaggcgaaag aaatggccag aaaattattt acacctatta 2074801 caattaaaga tatgacgtta aaaaaccgca ttgtcatgtc gccaatgtgc atgtattctt 2074861 ctcatgaaaa ggacggaaaa ttaacaccgt tccacatggc acattacata tcgcgcgcaa 2074921 tcggccaggt cggactgatt attgtagagg cgtcagcggt taaccctcaa ggacgaatca 2074981 ctgaccaaga cttaggcatt tggagcgacg agcatattga aggctttgca aaactgactg 2075041 agcaggtcaa agaacaaggt tcaaaaatcg gcattcagct tgcccatgcc ggacgtaaag 2075101 ctgagcttga aggagatatc ttcgctccat cggcgattgc gtttgacgaa caatcagcaa 2075161 cacctgtaga aatgtcagca gaaaaagtaa aagaaacggt ccaggagttc aagcaagcgg 2075221 ctgcccgcgc aaaagaagcc ggctttgatg tgattgaaat tcatgcggcg cacggatatt 2075281 taattcatga atttttgtct ccgctttcca accatcgaac agatgaatat ggcggctcac 2075341 ctgaaaaccg ctatcgtttc ttgagagaga tcattgatga agtcaaacaa gtatgggacg 2075401 gtcctttatt tgtccgtgta tctgcttctg actacactga taaaggctta gacattgccg 2075461 atcacatcgg ttttgcaaaa tggatgaagg agcagggtgt tgacttaatt gactgcagct 2075521 caggcgccct tgttcacgca gacattaacg tattccctgg ctatcaggtc agcttcgctg 2075581 agaaaatccg tgaacaggcg gacatggcta ctggtgccgt cggcatgatt acagacggtt 2075641 caatggctga agaaattctg caaaacggac gtgccgacct catctttatc ggcagagagc 2075701 ttttgcggga tccatttttt gcaagaactg ctgcgaaaca gctcaataca gagattccgg 2075761 cccctgttca atacgaaaga ggctggtaat gcccataaga gatatcctgt agaggatatc 2075821 tcttttttta tttttagaga aacgatcggc taaggttctc cgtctcccta gtagaaccaa 2075881 ttagaggaga tgactccaat gaaatcagct tggatggaaa agacatatac aattgacgga 2075941 tgtgcgtttc atacacagca ccggaaagga tcaagcggtg taacgattgt ctttgaggcc 2076001 ggctatggta cttcttctga gacgtggaaa ccattaatgg cggacattga tgatgaattt 2076061 ggcattttca catatgatcg ggcaggcata ggaaaaagcg ggcaaagcag agctaaacga 2076121 acagctgatc aacaagtgaa agaattggag agtttgctta aagcagctga tgtaaaacct 2076181 ccttatttgg ctgtttcaca ctcatacgga gctgtcatca ccggtttatg ggcctgcaaa 2076241 aacaagcatg atattatcgg catggtcctt cttgacccag ctttaggcga ttgcgccagc 2076301 tttaccttta tacccgaaga aatgcacaaa tcacatacga gaaagatgat gcttgagggc 2076361 acacatgcag agttttcaaa aagtctgcag gagctcaaaa agcggcaagt ccacttagga 2076421 aacatgcctc ttcttgtgtt gtcatcagga gaacggactg agaaattcgc tgctgaacag 2076481 gagtggcaaa acttgcacag cagcatattg tctctatcta accaaagcgg ctggattcaa 2076541 gctaaaaaca gctcccacaa catccatcat gatgaacctc atatcgttca cttggctatt 2076601 tatgacgtat ggtgcgcagc gtgccagcag gccgctcctc tttaccaggc agtcaattaa 2076661 cgtaaaaaaa gaccgggccg taagggattc ccggtctttt atattatttt gtttcacggt 2076721 gaagggtata tttctttaaa cgcggtgaat attttttcag ctccaaacgg tctggattgg 2076781 tgcgtttatt ttttgttgtg atgtaatttc ggtctcccgt ttcagtgcaa agctaaagta 2076841 acatttactc tcataattaa catctcctta taaaacgtaa tgattacgtt ttattataca 2076901 acgtcatcac aaattgtcaa ataagagctc cgccttcagc ctcgcgggac gtttacctct 2076961 aagaaatcat atgccgccac gctattgggg aaaacgtcaa ccgcttcttt ttgaagctcc 2077021 aaagaagcat ctccctgata tcttgcgctg atatgggtta aaatgagctg cttcgctctt 2077081 gcttctttcg ctgttacagc cgcttgttcc gttgtactgt gataataatc ataagcaagt 2077141 ttacggtctt ccttagcaaa ggttgcttca tgaacaagca catcacaatc cctcgcaagc 2077201 tcttttagtt tgtcacttac tctcgtatca ccggagaaca caacagatct tcccttttta 2077261 ggaggctcca gaaaatcatt cccattgatg attcgtccgt cttcaagcgt taccgtttcg 2077321 ccttttttga ttttctgata tacaggtccg ggcgggatgt tcatttcttt taatacgtca 2077381 gccttcaagg aacccggtac gtctttttcc tgcacacggt acccgaaggc ttccactcca 2077441 tgaataacag ataccgctgt gacaataaac tgatcgtcct caaacacgat tccttcttca 2077501 atttcctgga tcgcaagcgg atatgtcaaa tgggttttcg tgacggcaag gcttgtttca 2077561 ataaacgcct tgatcccttt aggtccgtac actgtcagct cgtcctctcc gccttgaaag 2077621 gaacggctcc ccagaagccc cggaagtccg tatacatgat cgccgtgcat gtgtgtaata 2077681 aagattttct ctattttacg aggtttaatc gttgtatgta aaatttgatg ctgtgtggct 2077741 tccccgcagt caaaaagcca taccgaacgc ctttcttcaa gcaattttaa tgccaccgac 2077801 gttacatttc tcgccttggc ggggatgccg gctcccgtcc ctaaaaaaag taattccacg 2077861 tttccttcct cctactagaa ccagatacct acaagaatac aggatcaagc ggaaaatgtg 2077921 aatcttgcct ctgaaaagaa caatcctttc gtgctagaaa cattttttca gcattctgct 2077981 taaaaaaggg cttaaatgtt tgctttcgtt gaattttaga tttaaaatga aggaaatata 2078041 cggggtgtac taaaataaag cttcgaataa agtgaggtac ttttagtgaa aacaaaccaa 2078101 caaccaaaag cagtaattgt catattcggt gcaactggag atttagcaaa acgaaaattg 2078161 tatccgtcta ttcaccgttt atatcaaaac ggacaaatcg gagaagagtt tgcagtggta 2078221 ggagttggaa gaagaccttg gtctaatgag gatcttcgcc aaactgttaa aacatccatt 2078281 tcctcatctg cagataagca tatagatgat ttcacgtctc atttttacta tcacccgttt 2078341 gacgtgacaa accctggttc ttatcaagag ctaaacgtat tgcttaacca gctggaagat 2078401 acatatcaaa ttcctaacaa cagaatgttc tacttggcaa tggctcctga attcttcgga 2078461 acgattgcaa aaacattaaa atcagagggt gtaacagcta caaccggctg gtcccgcctt 2078521 gtcatcgaaa aaccgttcgg ccatgatctg ccaagcgcac aggcattgaa taaagaaatc 2078581 cgcgaagcat ttacggaaga tcaaatttac agaatcgacc attatctagg caaacaaatg 2078641 gttcagaaca ttgaagtgat tcgatttgcc aatgcgattt tcgaaccgct ttggacaaac 2078701 cgctacattt caaacattca aatcacatct agcgaatcac taggcgttga agaccgcgca 2078761 agatattacg aaaaatcagg cgcccttcgc gacatggtgc aaaaccatat tatgcagatg 2078821 gttgcccttc ttgcaatgga gccgcctatc aaattgaaca cagaagaaat ccgcagcgag 2078881 aaagtgaagg tgctgagagc actgcgtcct attgcaaaag acgaagtgga tgaatacttt 2078941 gtgcgcggac aatatcatgc tggtgaaatt gacggtgtac cggttcctgc ttatacagat 2079001 gaagataatg tcgctcctga ctccaataca gaaacctttg ttgccggcaa gctcttgatc 2079061 gacaacttca gatgggctgg tgttccattc tacatcagaa ccggaaaacg aatgaaagaa 2079121 aagtccacaa aaattgtcgt tcaatttaag gacattccga tgaacctgta ctacggtaat 2079181 gaaaacaaca tgaatccgaa cttgcttgtc attcatattc agcctgacga aggcattacg 2079241 ctttacttaa atgctaaaaa gcttggcgga gcagcacacg cacagccaat caaactcgat 2079301 tattgcagca attgcaatga cgagttgaac acccctgaag catatgaaaa actaattcac 2079361 gactgtcttc ttggcgatgc aacaaacttt gcacactggg atgaagttgc cctttcttgg 2079421 agctttgtcg actctatttc tgaaacatgg gcagcaaaca aaaccttatc tcctaactac 2079481 gaatcaggct caatgggacc gaaagaatct gatgatcttt tggtgaaaga cggcttacac 2079541 tggtggaaca tataataaga agaaaaaagc cgaaaatgtt tacaagcatt ttcggctttt 2079601 ttacgctgaa caaaggtata acaatctcct taataacaaa acccccaaag cttaagagct 2079661 tcgggggttt ctattgatta cttcatccat tcagtatgga agatgccttc tttgtcagta 2079721 cgctcataag tatgagcgcc aaagtagtcg cgctgtgctt ggattaagtt tgcaggcagt 2079781 acggctgtgc ggtagctgtc atagtaggct aatgcgcttg agaatgatgg caccggcaca 2079841 ccttgggcaa ctgcaagtga aatcacttgg cgaagcgctc cttgatagct ttctacaata 2079901 ttcttgaaat agctgtcaag aagcaggttg tcaagctcag gctcgcgatc gtaagcttct 2079961 ttgatcttct gaaggaatgc cgcgcgaatg atgcaaccac cgcggaagat catagcgatt 2080021 tcaccatatt tcagatccca gttgtattct tcagaagcag ctttcatttg ggcaaatcct 2080081 tgcgcgtatg aacagatttt actcatgaac aacgcttttc tgaccgcttc aatcagctct 2080141 tctttatttt ctgtaacagg cttcacttct ggtcctgaaa gaagtccgct cgcttttaca 2080201 cgctcttcct tcatagctga gataaagcgt gcgaatacag attcagtaat aatcggaagc 2080261 ggaacgccta agtcaagtgc gctttggctt gtccattttc ctgttccttt ttggcctgct 2080321 ttatcaagaa tcacatcaac aagcggtttg cctgtttctt cgtctttttt tgtgaagatg 2080381 tcagccgtaa tctcaatcag gtagctatca agctcacctt tattccattc agcgaaaact 2080441 tcatgaagct catcagcaga aaggcccagc acctgtttca gaatgaaata tgattcagag 2080501 atcagctgca tatctccgta ttcaattccg ttgtgcacca tttttacgta atggccggcg 2080561 ccgtccggac cgatatatgt cgtacaaggt tctccgtcaa cttttgcaga aatggcttca 2080621 agaatcggtt ttacaagctc atgtgcttct ttttgtccgc caggcatgat agaaggtcct 2080681 ttaagcgctc cttcttctcc gccggaaacg cctgttccga taaaatgaat gccgctttca 2080741 gcgagttctt tgttacggcg ctgtgtatct ttatagtatg tattaccgcc gtcaattaaa 2080801 atatcatcct tctctagatg aggaagaaga gattgaattg tcgcatctgt tgcagttccc 2080861 gctttaacca ttaataagat tttgcgcggt gtttccaagg attggacaaa ttcttcaatg 2080921 ctgtaagtgc caacaacatt ttttcctttt gcctcctgta aaaactcctc agttttactg 2080981 cttgatctgt tgtaaacaga aacagaaaat ccccggcttt cgatatttaa agccagattt 2081041 ttacccatga ccgcaagtcc gataacgccg atttgttgtt ttgacatatt ctaacgtccc 2081101 ttctgcaaac gtttaatcat tttaaaattt aaattaaaat aaaatgatat ttataataaa 2081161 gaaattacca tacattcacc ctttttttca agcgattcag cttttctttt catcttgaaa 2081221 aaaatcttta ttaaagcttg ttccctttgt tttgctctcc tcttttttta acgttgcccc 2081281 ttttctgatc agtttggtac cgtacttttt attcagcttt tccatcatct gctgaatggg 2081341 ctcatccttc gcatcttcat taaagctgaa caaatcgagc tgtttatagg cctgctcttt 2081401 ttctactaaa tccgttccgg taatgccaag cagcctgaca ggatttttat tccaatgttt 2081461 aaaaaagagg tgctccgctt ctttcaaaat gtcatttttt tgatcaatcg ggtttctcag 2081521 cgtagtgctt cttgtgatgg ttctccaatc cgcatatcta atcataataa aaagcttcga 2081581 agccatgact tccttgcgct gtaaacggtc actcacagaa gcggcaagct ttctaaaaac 2081641 gcctaacagc tcttcttcat cactggaatc atgggaaagt gtcgatgagt tgccgacgct 2081701 tttaaattcg taaatgcgct ccgggtcaac cggcgcatgg tgaatgccat ttgctttatt 2081761 tttaaggcgc ggaccgttga tgccaagcag gcgcttcagc gagtgttcat cagctgcagc 2081821 tagctctccg attgtatgga tgccgagtcc cttcagtttt tccgctgtct ttttgccgac 2081881 tccgtgcatc tctccaacag gaagcggcca caggatatcg ggcacttgcc tctttcttaa 2081941 gatcgtaatt ccaagcggtt ttttcatatc agacgccatc ttagcgagaa atttattcgg 2082001 tgcaatccct atgcttgacg ggagcagcag ctctttttgc agcctgcttt ggatttcttt 2082061 tgccgtctct agagcgcggc tgctgtatgg tgtatcggtc atgtccatat agccttcgtc 2082121 gatggagaca ggctccacta ggtcagtata ttcacgaaga atggtaaaca tcgctcgtga 2082181 agagtttcta tagcggtcaa agttcggcgg aagaacgatg agctcaggac aatggcgctt 2082241 cgcttgccaa accggcatcg ttgttttgac gccgcgcgct cttgcttcgt agctgcatgt 2082301 taccacaatg ccctttcgct cctttacgtt tccggcaact gcgaccggct ttccccggag 2082361 agccggatca tatgccattt caaccgacgc ataaaagcta ttcatatcaa tatggaaaat 2082421 aattcggctc tttcccggca taaacaaatc tccttttcgg tcattagaca acagcttgta 2082481 catatagtaa aatgaagcta ttgaatggat gtgatgacaa tgtttgtgga atcgataaat 2082541 gacgttttat tcttagtcga ttttttcaca attattcttc ctgctctaac ggcaatcggg 2082601 attgcattcc tcttacggga gtgccgtgcg ggcgagcaat ggaaatcaaa acgaacagat 2082661 gaacatcaga cggtctttca cattaaccga acagactttc ttattattat atatcatcgc 2082721 attacaactt ggatacgtaa agtcttccgc atgaattcgc ctgtgaacga tgaggaagac 2082781 gccggttctc ttcttttata aaccgcattt ataaaaagga ggagaacaaa attgttaaaa 2082841 acatatcaaa aacttttggc tatgggtatc tttttgatcg tattatgctc gggcaatgct 2082901 gcatttgcag cgactaatca ggtgggaggc ctcagcaacg taggtttttt ccacgattat 2082961 ttaatcgaac cgttttccgc tctgcttaag ggtgttgccg ggctgtttca cggagaatac 2083021 ggactctcta ttatcctcgt aaccattatt gtgcgtatag ttgtattgcc tttgtttgtc 2083081 aatcagttca aaaaacagcg catcttccaa gagaaaatgg ccgttattaa acctcaggtt 2083141 gacagtatcc aggttaagtt gaaaaagacg aaggacccgg aaaagcaaaa agagctgcaa 2083201 atggaaatga tgaagctgta tcaggagcat aatatcaacc cgcttgcgat gggctgtctt 2083261 ccaatgctga ttcagtctcc gattatgatt gggctttatt acgcgattcg ctcaacacct 2083321 gaaattgcgt cacactcgtt tctatggttc agtttagggc aatctgatat tctcatgtcc 2083381 cttagtgcag ggattatgta ttttgtccaa gcctatatcg ctcaaaaact gagcgcgaaa 2083441 tattccgctg tcccgcaaaa ccctgcagcg cagcaatccg caaaattgat ggtgttcatc 2083501 ttccctgtga tgatgacgat tttctcgctt aatgtgccgg cagcccttcc gctgtactgg 2083561 tttacaagcg gactgttttt gacagtgcaa aacatcgtcc ttcagatgac gcatcataaa 2083621 agtaaaaaaa cagccgctct tactgagtcg gtgaaataaa aaagcaaccc cgtgcaaaaa 2083681 gccggggttg ttttttgtta cttgcaaagt accgcgccaa acagtcttgt ttatcatggc 2083741 tgaagcagaa atggccatcc taaaaaatag ccgtatcgtt taaaaagaag gaaatcggga 2083801 atacctttac tcacctccaa ccgaaaggag cctatacgtt gacggaacgc tttcagcaaa 2083861 aaaatatttc tgtacctgat ggaatctgga tcatgagaca aacctggaat gatgtcttat 2083921 ttgctcactg gcctgttgat gtttctatcc ttcgcgcttt ggtaccgtcc gttttagaat 2083981 tagatacata taacgggcaa gcttggatca gcatgcttcc ctttatgctc acgaacctga 2084041 gggcgcgtta tctccctgtc attcccggtg cgcgtgcatt tcctgagctt aacctccgca 2084101 cctatgtcac gtataaaggc aagcccggca tttatttttt tagcttagat gccgatcatc 2084161 gtctggcggt ccttggcgct cgcacattct ttcatctgcc ttatttttac gcggatatga 2084221 agtccgaaaa aaacggtgat gccattgact atgtcagcaa gcggaaaaat gacaaagaag 2084281 cagcattcca cgccgcatac cggccaattt cagcgccttt tacagcagaa aaggattcgc 2084341 tcgattactg gctgacagaa cgatacaggc tctacaccac ttatcgcaat aagctctatt 2084401 acgaagacat ccatcatcat ccgtggctgc tgcaaaacgc cgaagcagaa atttcagtca 2084461 atacggtgac tgatgctcac ggtattacat tgccggagtc agaccccttg cttcattatg 2084521 ctaaaaaaca ggatgtgtta ttttggccgc ttaggaaatg gagctaaaaa aacccgatgc 2084581 gggaaatcgc actcgggttt tcttttttta ttttgccgcc tcttcaataa tggcaacaac 2084641 catttctgcc gttttaacga gctcttcgat cggcattttt tcattttttg tatggatttg 2084701 ctcataaccg acagcaagat tgaccgtcgg gatgccatga ccagcgatta cgttcgcgtc 2084761 gcttccgccg ccgctcgttt gcagctcgct tggacgtccg attttagcag ccgctttttt 2084821 cgcgatttca acaacttggt cgccgtcttg atatttaaag cccggataca taacctcaat 2084881 ttcgacttct gcgcgtccgc ccatatcagc agctgcctct tcaaaagcag ctttcatttt 2084941 ttgaacctga gcttccattt tctcaggaac taaagagcgc gcttcagcaa gaatatgaac 2085001 ttcgtcgcac acaatgtttg tttgtgtgcc gccttcaaac cggccgatat tagctgttgt 2085061 ttcttcatcg atacggccca atggcatttt tgagatggct ttgctagcga ttgtaatcgc 2085121 tgaaatgcct ttttcaggtt caaccccggc gtgagcggtt ttcccgaaaa ttgccgctct 2085181 taccttcgcc tgtgtcggcg cggccacaat gatatttccg acttttccgt ctgaatcaag 2085241 agcatagccg taggatgcag tgatcataga acggtcaagc gccttcgctc cgatcagacc 2085301 cgattcttcc cctactgtga tgatgaattc aatcgtgccg tgttcaatat tttcttcttt 2085361 cagcacctta atcgcctcaa acattgcagc caatcccgct ttatcatcag cacctaaaat 2085421 cgtcgtgccg tcagttttga cgtaaccgtt ctctacaact ggttttacgc cgtttccggg 2085481 tacaactgtg tccatatgag atgtaaaata gatcgtatct gtttgttttg tcccttttag 2085541 cgtgcaaatc aggttaccgg ctccgtggcc cgtgatatcc attgtatcgt cttctttaac 2085601 gtccacacct aaatcagaaa attttcgttt cagcactttg cagatttcag cttcgtgctt 2085661 tgtttctgag tcaatttgga caagctctaa aaattcttcc agcaggcgtt tttcattcac 2085721 catttgtaag tccctccata ttaaagcggt atgttaccgt gctttttttt cggtctctct 2085781 tctgtcttat gtgtaagcat atgaaaagct tgaatcagtc ttccccttga ttcttccggc 2085841 aaaatgatgt catcgaccat tccacaagcg gccgctttgt atgggccggc gttttgcttt 2085901 ttgtattcag cagttttttc gcgtttcgtc ttttgcgggt cagctgaagc tttgatttcc 2085961 ttttcataca aaatcgatgc cgcaccttct ggacccatca ctgcgatttc agcattcggc 2086021 catgcaaaca caaggtccgc tccgatcgct ttgctgttca tggccacata ggcgccgccg 2086081 tacgcttttc taatgatgag tgtgactttt gggacagtcg cttcagcata agcaaacaat 2086141 aattttgctc catgcctgat gattccgttg tgctcttgct gaatacccgg cagaaacccc 2086201 gggacatctt cgacagtcaa cagcgggata tcaaatgcgt cacaaaaacg gatgaacctt 2086261 gctgctttat cagcagcgtc aatcgtcagg cttcccgcca gatgcttcgg ctggctcgcc 2086321 acgatgccga ttgctttttc acccagcctt gcaaacccaa tgacaatgtt cttcgcaaaa 2086381 aatggctgaa tctcaaaaaa agactgcggg tcagccagct ccctaatcac cttccgaaca 2086441 tcataaggct ttgtcgtatc agcagggaca agacggttta ataacggtct ggacgcctct 2086501 ttctctggct tcggctctgt tgtccggcca ttcagcggca aataagacag tagttttctc 2086561 acccctgtca gaacctcctt ctccgtatgc ccggaaaagt gggcgtttcc gctgacggca 2086621 ttatgtatcc ccgctccgcc taagctctcc gcatcaacct gttcccctgt cactttttca 2086681 atcaccttcg ggccggtaat aaacatccgg ccagtctgtt cagccataaa tataaaatct 2086741 gtgagtgccg gagaatatac agcgcctcca gcgcacggcc ctaaaataac cgatatttgc 2086801 ggaatgactc cggaatataa gacgtttcgg taaaatatgt gaccgtatcc atctaatgat 2086861 aacacaccct cttgaattct cgcaccacct gagtcattca gcccgataat cggcgcctta 2086921 ttttttgctg ccagatccat caaagcgcag attttcctgg catgggtttc gccaagcgcc 2086981 cctccgtaca ctgtgaagtc ttgcgcaaat acataaactg agcgaccgtc aattgtgccg 2087041 taccctgtca cgaccccatc ccctaacatg cgctgttctc ttgttaacac ttgactttcc 2087101 atgaaggggt gtaattcgat aaagctgtcc tgatctagaa gaaatatgat cctttcccga 2087161 gcagtgagct tgcccttttg ccgctgctga gccagctttt cccgtcctcc gccttcttct 2087221 gcctgcttgc gtttcgtgta aaaatgatcc atgtgctcat tcatgctcat tgtgttggtc 2087281 tcctttcggt tcacaaagct ctacaagaac accgtttgtt tcccgagggg aaataaacgc 2087341 gatctttttc ccgttcgctc cctgtcttgg aaacctgtca atcaattgaa catgctgatc 2087401 agacaatgct tgaagctgtt cagataggca gttgcacaaa aacgcaatat gatgcagtcc 2087461 ctgccctttc ttctccaaaa ataaatggac ggggctgtca gctgtcaacg gctctatcag 2087521 ctcaagtttg acgctaccag cttgaaaaaa agcaacattc accttttgct cttcaaccgt 2087581 ttcttgatga agaaatgcaa gccccaatac attttcataa aagcttcttg catcttttat 2087641 cgaaaaaacg gctatcccga tatggtcaag cctgttcatt ttcatccctg ctttcgctaa 2087701 tagatatcgc ttgtccgccc attcaaaaca cgctaaaata tagacagatt gtttaaggag 2087761 tgaaaatcat gtctcaaaaa ctgatgaaaa gcgttttgat cgtgattttg ggagttttta 2087821 ttctttcaac tgtactctca ggaatcgtca tgtttctata acgataaaaa agcaggcgcc 2087881 ttattcaatg ggaatatcct gcttttttat cagagcttta tgctcgatgg caatctcctc 2087941 aaaagagcgg ttgtcgtccg tgatcagcac tctcgttcct actggtatcg tttgaaacaa 2088001 atgaacaacc tcatcgttat gcatacgtat acagccgtta gacacaaatt ttcctactga 2088061 ttcctctcgg tttgtcccat gaattccata aatccgcccg tccgttcctt tcgcgtcaaa 2088121 tccgatccat cttgccccaa gcgggttatc aggagatccc ccttcaatat ttttctttct 2088181 gtagtaagga ttttccgctt ttaccgttac cgaaaactct ccttcaggcg tcaaatcatc 2088241 tgtttttcca gtcgccacac tatacacgcc ttctactttg ttgtcgagga taacagcaag 2088301 ttcatttgtt cgcttgttga caataacata cggatcaccc ggcagcggat tttcgccgag 2088361 cggccaaatc ggtgaaatca tcatgaaaat cgaacataag aaaaaacgca taagctcctc 2088421 ctttttcatt aggttgacca atgaaggaag agctcatgcg aatcatccga gtgatttttg 2088481 cgcttttatt cctttaaaat aacttttaat cactaaatat tgttccattt cgccgagaag 2088541 atggaagaga gcggccctcg cttcaaattc ctctctagtc gcaggaagcg gcatctcctc 2088601 aaattctttt ctcatgtcag caagtctttt cagaaatttg tatgctgtat tcccagggtg 2088661 tatcgcctcc cgcaaatcat gaataaattc agcgatcatt tttccctgat ctaccgtgat 2088721 ggagatcgat gtcactttag ggagaaggcg ttcgataatt tcaaattgct tttctctcat 2088781 tttaaaataa tgataatgca gattttcata acgcaaaatg tggttttgca catctcgata 2088841 tgccaggttt ttagcctccg taatgagctg gtgcgtttcc ggaatttctt ttcctgacca 2088901 atcttgctca ccagttaaca aataccgttc gatttctgca aaaatgacag caaagttatc 2088961 ctctatcttt ttgcggtagg caatcagttt ccggtcaaga ctaggcatat acaagttcat 2089021 caatagagcg acgccgatgc caaccgtaat cagctgaact tcattccaga tgaaagtagg 2089081 cgtaatgccg ccggacatgt ataaatgaag gataataaca gaactggtga cgataccctc 2089141 gttaattttt aacagaaccg ttatcggaat gaatatcaaa agaagcgctc cgatcacaaa 2089201 cgggtggtag ccaataagct cgaaaaagag ataagaaaaa gcaattgcca gacagcatgc 2089261 cgaaaagcgg gcccatgagg cctgaagcga ccgtttttgt gtgatttgta tgcacaaaat 2089321 ggtgatgatt cctgctgatg cgaagttttg caaatgcaat aactggctta tataaatagc 2089381 caaagctgtt ccaagcgcgg tctttattgt gcggtaacca attttaaaca tgtcggactc 2089441 catttctatt tgtttcttca ataaaaaaga agaggcggcc agccttcttc ttttttatat 2089501 tctataatat tttctctaaa aagtcctgcg ctcttttgga ttttggcgac ataaaaaatt 2089561 ccttcggatt gccgtcttcg acaatcattc cttggtccat aaacagcaca cggtctgcca 2089621 cttcttttgc gaagcccatt tcatgtgtga caatcaccat ggtcatgccg gtttcgacca 2089681 gctctttcat cacctgtagc acttctttga ccatctctgg atcaagggcg gaggtcggct 2089741 cgtcaaacag catgatgtcc ggattcatcg caagagccct ggcaatcgcg acacgctgtt 2089801 tttgtccgcc agacaaacgg tttggatagt catttcgctt ttcaaacaaa ccgactttgc 2089861 ggagcaggtc ctcagctttc tcctgtgcag cctgttttga ttcttttttt acattgacag 2089921 gcgcgtacat gatgttttcg agaaccgttt tgtgcggaaa gagatgaaaa tgctgaaaaa 2089981 ccatcccgat gttttcccgg acctttaatg tgttggtttt cggcttcgta atctctgtgt 2090041 cttttattgt aatggttccg ccgttaggct tttccaacag gtttaaacag cgtaagaacg 2090101 ttgatttgcc tgagcctgaa ggaccgatca cggcaacaac ctcaccctca gcgattgttg 2090161 ttgaaatgtt ttttaatact tcgtgtttcc caaatgattt tgacagcttt tcaaccttaa 2090221 tcattggatt tcagcttcct ttctacagcc ttgccgataa acgttaaaat caggacaagc 2090281 acataataaa tcaatcccgc gataatgagc ggctcaaggt aattgtaagt ggcggcgcca 2090341 gcttgatatg cgcgtctcat gacatcacca agcccgatga cggtgacgat cgccgattct 2090401 tttgttaacg taattaattc attcacaatt gcaggtgata tatttttgaa ggcctgcggc 2090461 agcagcagat ccttcatcat ttttccatac gggacaccga gtgcaacagc agcttctttt 2090521 tgccctttat caatggcatt gattccggct ctgataattt ccgatacata agcggcggaa 2090581 ttcaaagaca atgcgacaac cgcagcccaa aactggtcaa tttgaaatcc gagcagctga 2090641 ggaaggccaa aatagacaat cataagctgc agcactaaag gcgtgcctcg gaacactgat 2090701 gtataaaaat cagcgatcca gataaacggg cggaatgtgc tgatcttgca taagcttagc 2090761 acaataccga gtataagtcc gataatagca gatacaacaa caatttttaa tgtaattgcc 2090821 aagccttcta atataaaagg aatttggggg atcgttgctg aaaaatccaa attcatagcc 2090881 tttgtctcct tttcttacag gaaaaaagtt tcctattcaa taaaaaggct caacgaaaaa 2090941 gttgagccgc ttttttttac ttctcgccag tgaaccattt tttcttcaat ttctcaagct 2091001 ctccgttatc ttccatttcc ttgagcgctt tattgaattt gtctgtcagt tcactgtcct 2091061 ttctgaaagc aattgctgaa ccggcttctt ccgctttcgc atcaggaatc acaaagcctt 2091121 gcaggtcatc atttgatttg aaataccctt ctgcaacaat gtcttcaata atcgcggcat 2091181 cgaagcggtc agatttgatt tcctgcacca aatcagaaat tctgttgcgg tcttctgttt 2091241 taaaaccata ttccggagaa agctctttcc ccttctcttc ctgaatagag ccaagctgaa 2091301 cgccaactgt ttttcctttc aggtctttca aagattgaat gccgctgtct tttttgctga 2091361 caatcatatg gttcgctgtg taatacacat cggaaaaatc aacttgtttt ttacgctcag 2091421 gcgttggtgt cattcctgac agaacgagat ccacctgttt tgatttaagc gctgtaatta 2091481 agctgttgaa gtccatatcc tgcacttcaa tttcatagcc tgccttcttt gccagagctt 2091541 ttgccagctc tacatcaaag ccgacaatat tatctccttc tttatattca aacggtttgt 2091601 aatccgccga agtacccata attaattttt tctttccgct ttctgaacct gaattgcttg 2091661 agccgcacgc agttaatgca aaggtgatgc aagcagccac aagtaataag agccattttt 2091721 tcatgatcca tttcccccgt attcattact tttggtgtat ttgaatattt attcgttaat 2091781 ttgtatttta aacagtttct catttttatg caatactatt tttaaaaatt atctttaggc 2091841 ttatctttcc agtgatctct tctgatatta ctagataaaa attaaatcgc tgtacaatcc 2091901 gattgaataa tcccttaata tttattcata tatccttgga aatttatgca caaaaaaacc 2091961 cgggctgctt tgagcatccg ggttgttcgt cttatacttc ttcacaatat tcttcaaagg 2092021 cttcctgcag ctttgccact acagccatcg gctcatggcc ttcaatttca tgacgctcta 2092081 ccattttcat gatctttccg tctttcaaaa tcgcaaagga cggagaagat ggtggataac 2092141 cttcaaaata gtcacgcgca cgcgctgtcg cttctttatc ctgtccggca aaaacggtga 2092201 cgagctgatc aggtctttta tcatagtgaa cggaatggta ggctgccggt cttgcaattc 2092261 ctccggcgca tccgcaaaca gagtttacca tgacgagcgt cgttcctttt ttcgtaagtg 2092321 cctcatccac ctcttcggct gttttaagct cggtgtatcc ggcagctgtt atttcttgtc 2092381 tcgcttggcg gacaatatca ttcataaata aattaaagtc catgttcaat gaagacctct 2092441 cctttttcat catctgttct tatgatagca aggaaacgtc catatcggca aatgactttg 2092501 cttcgccgtg cacttttttt gctcttcgtt tactgcttac agaaaaaggg gattatataa 2092561 ccagaagtaa aataaaggag cagttgtata tgagccaccg gaaagcgtta ctgattcata 2092621 acggaaatgc cggcaacaaa aatatagaaa aagcacttgg tgctgtggtg ccggttttat 2092681 ctcaccattt agatgaggtg attattaaac agacaaagaa aaaggatgat gcgtatcatt 2092741 tttgccgatc cattgatgat tctgtcgaca ccgtcttcat tctcggcggc gacggcacga 2092801 tccatcaatg cataaatgct atcagcgctc tagaaagaaa acccgctgtc ggaattttgc 2092861 ccggcggcac gtgcaacgac ttttcaagag tgcttggcat ccctcaaaat cttgcaaagg 2092921 ccgcggaagc acttatggcg ggaaaaaaaa ccagcgtaga cgtatgtcag atgaatgacc 2092981 gttatttttt gaatttctgg gggatcggct taattgcaga aacgtcgaat caaatcaacg 2093041 aaacggaaaa agcattattg ggaaaaatca gctattttac aagtgccttg cgaaccgtct 2093101 catctgctgc atcgtttccg atgacattaa aaattgatgg agaagaaatt aaagaagaag 2093161 ccgttatgct gcttgtgatg aatggccaat acattggaac gaatcgaatt cctctgcccg 2093221 atgccagtat tgaagacggc ttacttgatg ttctcatatg ccgcaatacc aacctcaccg 2093281 cgctgcggga gctgatgagc atggaacaag gctcaattga tcgttttact ggagagttgt 2093341 cctatgtcca ggcttcccgt atcgagattg aaacagacac tgccaaaaag gcggatatgg 2093401 atggagaagt ttatacacat acacccgcag tcattcaggt cctgccacag catatcgaca 2093461 tgcttgttcc cgcaaatgaa taactgtcat aaggctttag aaagattttg caaatccgtt 2093521 gactctcccc taggaggagg tcttacagta taagggatac acacttgaaa aaggggaagt 2093581 catatggaga agaaaaatat taccttaact atattattaa ccaatttatt tattgctttt 2093641 ttggggatcg ggcttgtgat tccagtaacg ccgaccatta tgaatgaatt gcatttatcg 2093701 gggaccgcgg tcggctatat ggttgcctgc ttcgctatta cacagctcat tgtctcacca 2093761 atagccggac gatgggttga tcgcttcggg cgcaagatca tgatcgtaat cggcctgttg 2093821 ttctttagtg tgtcggagtt tttgttcggc attggaaaaa cagttgagat gttatttatc 2093881 tcccgtatgc tgggcggtat cagcgcagcc ttcattatgc ccggggtcac ggcttttatt 2093941 gcagatatca cgaccattaa aacacggcca aaagcgctcg gttatatgtc agccgctatt 2094001 tcaacaggat ttattatcgg ccccggcatc gggggatttt tagcagaagt ccattcccgg 2094061 ctgccttttt tctttgcggc agcttttgca ctgttagcag ccattttatc aatcctcacg 2094121 ctgcgcgagc cggaacgaaa ccctgaaaat caggaaataa aaggacagaa gacaggcttt 2094181 aaacgaattt ttgcccccat gtatttcata gcttttctca ttatcttaat ttcgtctttt 2094241 ggtttagcat catttgaatc tttatttgca ttattcgtgg atcataaatt cggatttacg 2094301 gccagcgaca ttgccattat gattacagga ggagcgattg ttggcgccat tacgcaagtc 2094361 gtcttattcg accgcttcac aagatggttt ggcgaaattc atttaattcg gtacagctta 2094421 attctctcga cgagtctggt attcttgctg acaacggtac attcatatgt tgcgattctg 2094481 ctggtgacag tcaccgtatt tgtcggattt gatctcatgc ggcctgcggt aacgacttac 2094541 ctgtcaaaga ttgcgggaaa tgaacagggg tttgccggcg gtatgaattc aatgtttaca 2094601 agtatcggca atgtattcgg gcctattatc ggcggaatgc tgttcgatat agatgtaaac 2094661 tatcctttct actttgcaac ggtcacctta gccataggga ttgcactgac cattgcttgg 2094721 aaagcgcctg cacatcttaa agccagcacg tgataagaag cgcattcttt gtgtactgca 2094781 aagaatgcgc ttcttcttta tactgatgat agaaggagtg atggcatgaa ggaatcgtat 2094841 tactcaattg gggaagtatc aaaactggca aacgtgtcga taaaagcgct ccgttattac 2094901 gataaaattg atttatttaa accagcctac gtcgacccgg ataccagcta ccgctattat 2094961 acagattctc agctcattca tctggatttg atcaaatcat tgaaatatat cggcacacct 2095021 ttagaagaga tgaaaaaagc acaggactta gagatggaag aactgtttgc tttttataca 2095081 gagcaggaga ggcaaatcag ggagaaatta gactttttat cagccctgga gcaaaccatt 2095141 tcattggtga aaaagcggat gaaacggcag atggaatatc ccgcgctcgg tgaggtgttt 2095201 gttttagatg aagaagaaat acggatcatt cagacagagg cagaaggaat cgggcctgaa 2095261 aacgtgctca acgcctccta cagcaaatta aaaaaattta tcgagtcagc agatggattt 2095321 acgaacaata gctacggcgc tactttctct tttcagccct acaccagcat tgatgaaatg 2095381 acttaccgtc atattttcac acctgtattg acgaataaac agatttcatc aattacgccg 2095441 gatatggaaa tcacaacgat ccctaaaggg aggtatgcgt gtatcgcgta taatttttcg 2095501 cctgaacatt attttctcaa cttacagaag cttatcaaat atatcgcgga ccgccaatta 2095561 acagttgtca gtgatgtata cgagttaatc ataccgattc attactcccc gaaaaaacaa 2095621 gaagaatatc gagtcgaaat gaaaatacgg atcgctgaat aataaagcat agaaaaagag 2095681 cattttttga aacaaaactt caaaaaatgc tctttttgct tatttagtaa acagatgtct 2095741 tctcgtcaat cgattctaaa atttgtttca ctcgtccgag gaatcgtccg cacacgagac 2095801 cgtcaagcac tctgtgatct aatgacaggc acagattaac catgtctctg acagcaatca 2095861 tgccattgtc catgacaacc gggcgtttga cgatggattc tacttgaaga atcgcagcct 2095921 gagggtagtt gataatgccc atcgactgaa cagacccgaa cgaacctgtg ttgttgacgg 2095981 taaacgtgcc tccctgcatg tcatctgcag tgagttttcc gtctcttact tttttagcta 2096041 ggccggtaat gtctttcgca atgcctttaa ttgttttttc atcagcgttt ttaatcaccg 2096101 gaacaaataa agaatcctct gtggcaactg caattgaaat attgatatcc tttttctgaa 2096161 taattttgtc ccccgcccac atgctattca tttgcgggaa ttcttttaac gcctgagcga 2096221 ccgcttttac aaaaaaggcg aagaacgtta aattaaagcc ttctgtcttc ttaaaagaat 2096281 cttttatact gttgcgatat gcaaccatat ttgtgacgtc gacttccatc atcgtccaag 2096341 catgcggaat ttctgttttg cttcgcttca tattggaagc aattgctttt cttacacctg 2096401 tgacagggat ttctttatca ccggctgcag acgcaggata tgacgtctct tcttttggct 2096461 caggttttga tgcagacttc ggtgcaggag ctgctgtttt cagctcctca ggattctgtt 2096521 cttgcacgcc gcctgtttca attaagcgct gaatatcttt tcgtgtgatg cgcccgccgg 2096581 caccagttcc tgtcacttga tcgaggtcaa tgccgtgctc tccggccaaa cggagaacag 2096641 ctggcgagta gcgcttttta ttgggctgat cggctgctcc agcacttttt gcaacagggt 2096701 tctcagcggc ttctgatgct gctggctgtt cttgtttttg ttcagccgga ttcgcgcctt 2096761 ctgtttcaat tttgcaaatc atttctccga cttgcagggt ttggccttct tctcccacaa 2096821 gctctgttat cgtaccagta aaagaagacg gaacctctgc atttacctta tctgtcatga 2096881 cttccgcgat cggatcgtat ttgttcactt tatcaccggg ggcgacaagc catttgctga 2096941 tcgtcccctc tgttacgctt tctccaagct gcggcatcgt catttgttca attgccatga 2097001 ttgtatcctc ccttacgtct ttaaaactcc gctaattctc tcatcgccgc ttccacttta 2097061 tcagggttga ccataaagta tttttccatt gtcggcgcat aaggcatagc cggaatatca 2097121 ggacctgcaa gccgtttgat cggcgcgtct aagtcgaaca gacaatgctc ggatataatt 2097181 gcggctactt cgctcatgat gctgccttct tttgtatctt ctgtgaccaa aagaaccttt 2097241 ccagttttgg acgcagcttc gatgatggct tctttatcaa gcgggtaaac tgttcttaaa 2097301 tccaccacat gcgctgaaat gccatctttt tcgagacgtt ctgcagcttg taaggcgaag 2097361 tggacacaca ggccgtatgt gatcactgtg atgtcgtcgc cttccctttt tacgtccgcc 2097421 ttgccgattg gcaggacata atcatcagcc ggaacctcgc cctttatcag acggtatgcc 2097481 cgcttgtgct caaaaaacag cacggggtct tcgtcacgaa ctgcggcttt taagagccct 2097541 ttcgcgtcat atggtgttga tggcatgaca attttcagtc cgggctggtt ggcgaaaatt 2097601 gcttcgactg attgagaatg atacagggct ccgtgcacgc ctccgccgta tggcgctctg 2097661 acgacaatcg gacagctcca gtcattgttg ctgcggtagc ggattttagc cgcttcagaa 2097721 ataatttggt tgactgccgg cataatgaaa tcagcaaact gcatttcagc aatcggtctc 2097781 attccgtaca ttgccgctcc gataccgact cctgcgattg cagattcagc aagcggcgta 2097841 tccataacgc gctcttcccc aaattgttca tagagtcccg ctgtcgcttt aaacacaccg 2097901 ccttttcttc ctacatcttc cccaaggacg aaaacgcgag aatctcgttc catttcttct 2097961 ttcatcgcca aattgattgc atcaatatat gacattactg acatttgttc ttcctcccta 2098021 cttcgcataa acataatcaa gcgctgactc aggagctgca tatggggcgt tctccgcttc 2098081 atccgtcgct tcatttacga ttgccataat ttcatccagc atggtttgtt ctatctcatc 2098141 ggacagcagg cctgtttcct ttaagtaagc ttgataagta agcaggggat cacttttttt 2098201 cgcttcctct acttcttcac ggcctctgta gctgctgtca tcgtcatcac tggaatgtgg 2098261 tgtaaggcgg taagaaatcg tttcaattaa tgtcgggcct tctcctctgc gtgccctttc 2098321 gcgtgcttct ttaaccgctt gataaacttc cagcggatca tttccattca cagttacgcc 2098381 aggcatccca tagcctatgg cacggtcgga aatgttctca catgcgactt gcttatcgta 2098441 aggcactgag attgcgtatt tgttgttttc acacatgaaa ataaccggca gcttatggac 2098501 agcggcaaag tttgcccctt catggaaatc gccttggttt gaagaccctt ccccgaatgt 2098561 aacaaaggct gcgatatcct ttttctccat acgtcccgca agcgcaatac cgactgcgtg 2098621 cggcacttgc gttgtaaccg gagatgatcc cgtcacaatg cggtttttct tttgtccgaa 2098681 atgtcccggc atctggcggc ctcctgagtt cggatctgct gcttttgcaa acccggacat 2098741 cattaagtcc tttgctgtca tgccaaacgc gagcacgaca cccatgtctc tgtagtacgg 2098801 caatacataa tccatttcac ggtcaagtgc gaaagccgct cctacctgtg ctgcttcctg 2098861 tccttgacaa gagattacaa atggaatttt gccagaacgg tttaacagcc acattctttc 2098921 atcgattttt cttgctaaca gcatggttct atacatatca acggcttcct gatcagtcag 2098981 ccctagtgct tgatgtcggt ttgtactcat tcaagcccct cctttatgct tttaaaaatg 2099041 aatggctttg ccatctgcgg caagcgcagc ttctccaatt gcttcagaaa gcgttggatg 2099101 cgggtgaatc gtttgcccga cctcccacgg tgttgcgtcc agcactttgg caagacccgc 2099161 ttcagaaatc atgtcggtga catgcgggcc aatcatatga acgccgagaa tatcatctgt 2099221 atctcggtca gccacgattt tgacaaaacc gtcgctttca ccgtatacaa gcgcttttcc 2099281 aatcgccata aatgggaact tgccgatttt gacattatgc ccgttcgcct ttgcttcgtc 2099341 ttcggttaag ccgacactgg cagcttcagg gcttgagtaa atgcacttcg gcacaagcgt 2099401 cggatcaagc ggatgcggat tgagacctgc aaaatgctca acagcaataa ttccctcatg 2099461 tgaagcaacg tgagctaact gcaggccacc gattacgtct ccgattgcat aaatatgaga 2099521 ttccttcgtt tggcagcttt cattgactga aatcatgcca ttttcagtaa caatatcggt 2099581 gttctctagg ccgatgcctt cgatatttgc ctgtctgccg atggaaacaa gcattttctc 2099641 agcagaatag gtaacggttt ctccgtcttt ttccgcttgt atgctgatat cgtctgatgt 2099701 ttttgtcatt gtgtcaggca gcacttttgc ccctgttatg aactggatgc cttttttctt 2099761 aagaagactt tccatttctt ttgaaatctc tagatcttca gtcggcaata tgcgatccgc 2099821 gtattcaata accgttacct taacgccaaa atcatgaagc atagacgccc attcgatacc 2099881 gataacccct ccgccgacaa tgatgattga ctgtggcagc tcctccattt ggagcgcctc 2099941 atctgaagtc agtacagact taccgtccac ttcaagaccc ggaagcattc tcggtcttga 2100001 tcctgttgca atgatcactt gtttcgggat cagcatgtca ttttcttcgc catttccccg 2100061 ctcaacagaa attgttcccg gcagcggaga gaagattgac ggtccaagga tacgtccata 2100121 tccggtgtac acgtcaattt ttcctttttt cattaaatga tttacacccg ctgcaagctt 2100181 atcaacaacg gcttgcttac gctgctgcac tttttcaaag ttgagggaca cgccagccgt 2100241 ttccactccg aattgatcgg cttcacgagc tgtccggtat acctctgcgc ttctaagcag 2100301 cgctttactc gggatacagc ctttatgcag acatgttccc ccgagttttt ccttttccac 2100361 aacggctgtt tttaagccga gctgagcggc tctgatggcc gcaacataac cgccggtacc 2100421 gccgcccaga atgactacgt catactcagt tgccatggtg actcactcct gtctgtctat 2100481 tcaatacgat attgtttgga ttgctcttcg ccctgcaata ctcttagcgc cccttgggca 2100541 agagactgca gttcattttc acccggataa actaaaacgt ctgaaatcca atctatgtat 2100601 gatctgatag cagaaacaaa gctttttccg tacgcaaggc ctcccgtcag cacaatcgct 2100661 tcaacttcgc cttttaacgc cgcgctggct gccccgattt cctttgctac ctgatatgcc 2100721 atggcatcat aaatgaagcg ggctttttca tcgccccctt gaatcatctg ttccactttt 2100781 actgcatcat ttgtaccgag atagcctaaa agtccgccgg tgccaacaag ctttttcatg 2100841 atttcttctt ttgtatattc ccctgaaaaa catagatcaa caagatctcc cgcaggcact 2100901 gttcctgctc gttcaggact gaatggtccc tcgccgtgca ggccgttatt gacatccacc 2100961 actcgcccgc ggtcatggac gccaattgta atacctccgc ccatatgggt aataatcatt 2101021 ttcatgttct catatcgttt gccaagggag gctgccgctt tacgagcgac agctttttgg 2101081 tttaacgcat ggaaaatgct tttcctttca atttcaggca tgcctgaaac tttcgcaagc 2101141 actgacattt cgtctacgac aacagggtcg acgatatacg aagggatatt caggccgtca 2101201 gcgatttccc gcgcgataat gccgccgaga ttagaagcat gctgaccggc gtagccgctt 2101261 ttcaaatcct caatcatctc atcattcact acgtaggtcc cgccttcaat tggccggaga 2101321 aggccgcctc ttgcgcagac tgcatcaaac tttgaaatat tgattccctg ttcatgaagc 2101381 gtttcgagaa tatggttttt acgaaattca tactgatcaa taattcggtc aaatcgctgc 2101441 agctcttcta tgttgtgtct caatgttttt tcaaaaatgc ttctttcgtt atgaaaaaca 2101501 ccgattttcg ttgaagttga gcctggatta attgtgagaa tgcgtttttc gtcatgtagc 2101561 actttcataa cctccagatc aatttcttaa cgtctgctta atacactgtg gccgttttgc 2101621 aaaaactggc ttcttgagcg gcgcatgcgt tcaatccgtt cctctgctaa gcggtcagcc 2101681 gctaaatatg caggaatgcc gtcacgctga gaaatctcaa gtacacgctc gatattgccg 2101741 taaatgcctt caactttttt caatgcacgt tctgcattat agccgtaaag ctcatctgcc 2101801 acgttgatga caccgcccgc gttaatcacg taatccggtg cataaacgat gcccatttcg 2101861 tgaatttgat caccatggcg tgtctctttt aattggttgt tagccgcacc tgcgatcact 2101921 ttcgccttca gctgtttaat ggtgtcgtcg ttaatagtcg caccaagggc acacggcgca 2101981 taaatatcgc agtcttgtga ataaatgtca tcaggatcta ccgcacgggc gccaaaatct 2102041 tcaactgcac gctgtacaga ttgtttgttg atatccgtaa cgattaagtt tgctccttct 2102101 tcatgcaggt ggcggcaaag gttataggct acgttcccaa caccctgtac agcaatggtt 2102161 tttccttcaa gagagtcggt tccgaaagca gctttagctg ctgccttcat tcctctgtac 2102221 accccgtacg ctgtgactgg ggacggattt ccagaagagc cgaaagcagg agaaatccct 2102281 gtgacatagt ctgtctcatc atgaatgata tccatatcct cgaccgttgt gcccacatct 2102341 tcagccgtga tgtatctgcc attcagtcct tgaatatagc ggccaaacgc gcggaacatt 2102401 tcctcatttt tgtctttgcg cggatcgccg ataatgactg tttttccgcc gccaaggttt 2102461 aagcctgccg ccgcgttctt ataggtcatg cctcttgcca atctgagcgc atcttcaatt 2102521 gccgcttctt cattttcata tgtccacatt ctcgttccgc caagcgccgg accaagcgtt 2102581 gtatcatgaa tggcgataat cgcttttaat ccagattgtt catcctggca gaataccaat 2102641 tgttcgtaat cgtatttctc catatattta aaaagttcca tgttcgttcc tcctaatgtg 2102701 tgtattcttc agatgcgcat attgccagcg caatggaata cagtttattt tcagcagagt 2102761 ccgctctgct tgttaaagca atcggtgctt ttgctcctgt aatgacagcc gccacgctgg 2102821 ccttggcaaa ataaatcagt gatttatata aaatattgcc ggcctcaatt gttgggacga 2102881 gaaggatatc tgcgttgccc gctacgtctc ccgaaatttt tttctgggcc gcggcaattt 2102941 gtgaaactgc gttatccaaa gcaagcggtc catcaacaat gcagcctttg atctggcccc 2103001 ttttgtacat ttgagctaga gcagctgcat tcacggtcgc ttccatttta gggttcaccg 2103061 tttcgaccgc tgcaagggca gctgcttttg gcatattgtt ccccactgca tgggccacat 2103121 gaacggcatt ttgcaaaatc tgccggagct cttccagcga aggagcaata ttcattgccg 2103181 aatctgtcac aaacatcagc cggtcaaaat ccggtatatc gaagacagcc acgtgagaaa 2103241 ggacacttgc tgaccgaagc ccctcctgtc tgttcaatac cgctttaagc aaaacagaag 2103301 tcggcacatt gcctttcatt aaaacgtccg ctgttttatg atgcacagca cgaaccgcta 2103361 atttcgccga ttcctcagga gtattggcat ggacgatttc cacttgatgc ccttgcatgg 2103421 atgatgtcag ctcgttcagt tttttgctgt cgcccgttaa caagaaacgg gcggataggt 2103481 gctcggctgc cagctttaca gcccggatca cttcctcatc ctcagcatga gcaaccgcaa 2103541 tggtcttatt tttgtgtatc gacgctttgc cgattaaatc tttcagcttc atctgttacc 2103601 acctttcttg tttcgactcc gccttttatt atgcaagttc catgccagct cttaagggtg 2103661 ctgtcatacc aggtataccg aaacattcgt gcagatgttt gcgtttattc tgcaaattat 2103721 tgcatgcctt catttgcaag gccatattta tccattttgt aatataaatt ccgaatgctg 2103781 acaccgagag cttttgctgt ttttgtccgg ttaaaatgat gcttttcaag cgtttgctgg 2103841 atcaaatgcg cttcaaattt ttctactgcg acagacagct tttcgccttc aatatccgga 2103901 aaatcaaaac ctgttccctg atctgtgtca ttttcttttt gctcaagttc gaatacaggc 2103961 aagtgatctt tttcaatcca ttccatatgc ggattcagaa aaatcatggc tcgtccaagg 2104021 acattttcaa gctcccggac attcccaggc caatggtagg cagataaggc gcgcaaggct 2104081 tgctgtgaga gcccttttac attcctgccg taatcccggt tgatcttttg gataagtctg 2104141 acgctcaatg cttcaatgtc ctccaaccgc tgccgcaaag gcgggatgga gatcggatag 2104201 cgattgatcc ggtaatacag gtcttcccgg aatgttccgt ccgccatcgc cttttcaata 2104261 tttacatttg tcgccgcgat cactctgacg ttgacaggga tcgctttcgt gccgcccact 2104321 ctgacgattt ccttttcttg aaggacgcgt agcaatttgg cctgcatatt ttgtgtcagc 2104381 tcaccgattt catctaagaa aatactgccg ttatttgctt cctcaaataa acccttttta 2104441 ccgccgcgct tcgctcctga aaacgcacca tcctcatagc cgaacaattc tgattcgagc 2104501 aggttttcag aaagggctgc acaattcacg cgaataaatt tattgtattt ccggtcactt 2104561 tcgttatgga tggcatgggc gaacagttct tttcctgttc ctgattcccc gcgcagcaag 2104621 atggttgccg gtgttttcgc accgagcttc gcctgctcaa gcgcaaccag catttgctcg 2104681 cttttgccga taatgtcgtc aaacgtgtat ttcgcttcaa gcgtgcgaat aatttgtctg 2104741 gcgcgattaa gctccgctgt cagcatttta atttcggaaa catcgtgaat cacgccgacg 2104801 ctgcctttca aaatcccgtc cacaatcacc ggtgctacat taacgatcac ttctttttca 2104861 ttcgggccga ccttcattct gacaccgcgg acaggacgtc ttgtttcaag cacctttaaa 2104921 tgcatgcttt cgccttcgga aatatcagtg tttgcaggct tgccgatgac ttctttttca 2104981 gaaagccccg tcattttcgt atacgcttta ttgattagca ggccgatgcc gttttcatca 2105041 acgacagaaa tcgcctcatc ggaggattga ataattgcct ccagcatcgt acggacctgc 2105101 tttaagttgg tcacttcctc tgccagctcg accgcatcag tgatatcttt aaacacacaa 2105161 agagccccga gcagacgtcc gccttcatca ataatcggca gtcttgtggt cacaatttgc 2105221 aaatgatcgc ctaacagctg cttctggttg tattcaggca ctcttgtttt taaaatccgc 2105281 ggcatcttag tgctcggaat cacttctttt attgggcgcc caatgacttc ctcacgtttt 2105341 tttccgacca ttttttcggc catatggtta aagagaatga tttcttcatt gatatcaata 2105401 aaaatcattc catcatgggt ggaattaaaa attctgtcat atttataggt ttgctctttt 2105461 agcatttgaa tcaggtgctg cttttcttcc atcagctgaa aaacgatgta tgccattttt 2105521 cccggcatga caatggtatc ttcatgcttt ctttgaagga gctcgtcaaa cacggcttga 2105581 tcgccggtag tatgaatgac gatatccggt ttttgttgta tgtaaggttt ccaatcagat 2105641 gatacggcaa tcccatactg ttctgcttct ttcaatcccg gcgcctcggg gtctttgtca 2105701 actacggcaa tgatatctat gatggctgtt ttaatcagaa tatgtaataa cgccgttccc 2105761 cttttgccgg cacctactat cagtaccttt tgcatcccga tacccctttg tatgaaaaaa 2105821 tttgcacacc tatttattcc gttgcaataa tttgcacaac cctatgttac cacgttttct 2105881 tctcttgaca aaatattttt tccgctggac aataaaggaa atgaaaagat aaaggggttt 2105941 tctgaagatg agccgacttc ttgcgctttt aatattagtc atccccgggg ctatttctgc 2106001 tttaggcatt aaactgatga gagatacact tttcggccat acaatcaagc cattttcagc 2106061 tctttggctc caagggttgt caggattcat cttttttgcg atcggcctct atgtgctggc 2106121 cgggttcatt ttatacagag acagaaaacg caatcaagtc agcccgcgat tcagaaaacg 2106181 atagctgaaa aaaagccgga gaatgctccg gctttttttg ttgcattatt cgtcaggcaa 2106241 aacggtcttg gcaatcgttt tgtctaacgc ttcatagtca taataagaaa tcgtatcgta 2106301 cagttctttt cgtgtctgca tatcatgaag tccttctttt tgtgagccgt gctccttcat 2106361 caaaccaaac atccgctcac aagcttttgc cgccgctcga agcgaggtga caggatatat 2106421 caccatgtga aaccccatat cttcgaattc atcggcacga taatatggcg ttttcccaaa 2106481 ttcagtcata ttcgcaagga gcggaacggg gatacgctca gcaaactggc ggaattcatt 2106541 ctccgcctgt agcgcttccg ggaaaattgc gtccgctccc gcctcaatgt aagcctctga 2106601 acgttttatt gcggcatcaa gcccttcctg cgccctggca tcagtacggg caacaacaat 2106661 aagggagggt gccgcttgtt taatggcttt tattttttgc gccatttcct ttatcggaac 2106721 tagctgtttg ccatttaaat gtccgcattt ttttgggagc tgctggtctt ccatttgaac 2106781 ggctgctacc ctggcttcaa gcatctcccg ggctgttcgg gcggcattta agacaccgcc 2106841 aaatcccgta tcgatatcca caagcaaagg cagatcagct gcacgcacaa gatctttggc 2106901 ccgttcagct atctctgccg atgtgatgat ccctaaatca ggcagccccc tgctggctgt 2106961 ataggcagca ccggacaaat aaatagcaga aaaaccggct tctttcgcaa gcaaagcggc 2107021 catcccgtca tgggcgccgg gaatttgaag aatgtccggt gctgacatca gcttgcggaa 2107081 acgcccggca agctcctctt gtgacgattg cttattgacg atccacgaca tgaaacaaaa 2107141 tccccctttt acatgcagaa catgtctacg aattcattta cgcgcatcgt ttgtaatgtc 2107201 tcatagctgg tacagcgctc ataaatgtgt ttgtgctgtt tatcaggaaa atgggttttg 2107261 agattgtcag aaaacttttc cagcagtttc ggcactgctt cctctcttcg aaaacgatgg 2107321 ccgaggggaa actcacattc caccatttcc gtgctcgttc catctttaaa atgaacctga 2107381 acggcatttg agatggagcg tttatcaggc ttcaaataat cctcggtata tgttttattt 2107441 tcagtcactt ccattttatc acgaagttta tctattctcg gatcattcgc tgtttcagct 2107501 tcataatgct gtgcggtgat atcaccaaaa agcaaaccga ttgctgtaat gtattggagg 2107561 cagtgatcac ggtctgccgg attgtggagc gggccttttt tatcaatgat tcggatagct 2107621 gattcatgcg ttctgatgac aactcggtca atctcgtcaa tccggttctt tacctgcggg 2107681 tgaagaatga cggcggactc cgccgctgtc tgggcgtgaa attccgcagg ataagacact 2107741 ttaaataaca cattttccat gacataagcg tcgagcggac gggcaagctt gatctctttc 2107801 ttattgaata aaacgtcttg gaacccccaa cccggtgcac tcaaggctgt cggataaccc 2107861 atttcccctt ttaacgacat cagcgccaaa tgaacacctc tgctcgttgc atctcctgcc 2107921 gcccatgatt tacgcgagcc tgtattcggt gaatggcggt atgtcctcaa tgctgcattg 2107981 tcaatccatg cattcgaaag cgcatttttg atttcttctc ttccgccgcc caaaagcttt 2108041 gctgcaacag cagttgtcgc aactttgaca aacagcacat ggtcaaggcc aactcgattt 2108101 aagctgtttt ctaacgccag cacaccttgg atctcgtgtg ctttgatcat catctcaagt 2108161 acgtcgcgta ccgttaacgg ctcttttcct tcagacagcc tcactcttga tacataatca 2108221 gcagcggcaa ggattcctcc caagttatcg gatggatgcc cccactccgc cgccagccac 2108281 gtatcgttgt aatcgagcca gcgaatcatg cagccaatat taaacgctgc cctcacagga 2108341 tcgagaacat atgacgttcc cggcactttg cttccattcg gcacagtcgt tcctggaaca 2108401 atcgggccaa gcagctttgt gcattccgga taccgtagcg ccaagattcc gcagcccagg 2108461 gtatccagca atacatgccc cgctgttgta tacgcttcgg cactagtaat ctctttctca 2108521 agcacatagt ctgtgatttc ttcgataaca cgatccgttt tcggcattct accagctcct 2108581 ttcatgattt tgtttgatat cgcgggccca tgtaactgac acggggacgg aagagccgat 2108641 tattggcatg ctgttcgatc acatgggcgc ataaaccgga cgttctcgcg ctgaaaaaga 2108701 tcggcgtata taaaggaatc ggtatgccga gcatccaata cactggggca gcatagtaat 2108761 ccaaattcgg gtaaagccct ttttccttct ccatcagccg ctcacccgct tcgcacatct 2108821 catataaacg atggtcaccg gctttatcgc ataattgctg cagcgcctct ttcatcatga 2108881 gtgctctcgg gtccattttt ttcatataca cccggtggcc gaagcccatg attttttctt 2108941 ttcttttcag ttttgtttgc aaaagctgct caaaatcaga tgtcgttttt gcctccaaaa 2109001 gcaaatacat cacagcttcg tttgctcctc cgtgaagatt ccctttcagg gaagcgacag 2109061 ccccagtcaa agccccataa agatctgaat gtgtagatgc aatgaccctg gccgcaaagg 2109121 ttgaattcgg catctcatgc tcactgtaca ggacgagcga ccggtcaaaa atctgttctt 2109181 ccaatgaaga cggcaatttc cctgtcatca tgtagagaaa attcgcactg taggataggg 2109241 tttgaagcgg aagaatcggt tctttcttat taatgatcct gtagctggca gcagtgaggg 2109301 caggcatttt cccaagaagc tgataggcgc gttctttgtt tgcggaagga gaccgatcat 2109361 caatttgccg atcatagcca gcaagtgccg acaggccggt acgcagacca tccattggat 2109421 gagtgtcctc agggagcagc tcaagcagac ggagatgatc agcaggcagg cttgaggcac 2109481 tgtttatttt acgttccagc gtttccattt cactttcttc tggcagcctg ccctccagca 2109541 ataaatggac aagctccaga tagctttttg tttcagaaag ttctattaaa tcatagcctc 2109601 ttatcaaaat ctggctggac tgcgtgtcaa gataagaaat atgagtttct gccgcaatca 2109661 caccgtccaa ccctggagaa taatgctgtt tctcctccat atcctcaacc tccgtttttg 2109721 cgttttttgt ctatcaggtt ccgccaagca aatacttgga aataatcagt ctttgaatct 2109781 cgttcgtccc ttcataaatt tgcgtcacct ttgcatcgcg aagcaggcgc tcaactggat 2109841 aatccttcat atagccatat cccccataaa tttgaacggc gtctaacgcc gcctttacgg 2109901 ctgcatcgga agcaaattgt ttagccatag acgcttcttt tccacagttt aggccgcggt 2109961 tatgaaggtc tgcagcgtgg tagacaagat gtcttgccgc ctcagctcta gtcgccatat 2110021 cagccagctt aaatgatatg ccttgattgg ctgcaatcgg ccttccaaat tgcactcgct 2110081 gcttcgcata atcaacggca tgctcaagag ccgcctctgc aattccgagg gcctgtgccg 2110141 caatgccgat ccggccgaca tttaaattcg ccatggcaat gtgaaagcca tccccctctt 2110201 tgccaagcaa attggcttca ggcacttctg cattatcaaa aatcagttcc gtagtattgg 2110261 agccataaag ccccagcttt ctttcttttt ttccaacggt aaaaccgggt gtgttttttt 2110321 caacaataaa agccgaaatc ccgtgcctgc cttgatctgg agctgttaaa gcaaatgtga 2110381 tatagatatc agctgctccg ccattcgtta tgaatatttt cgatccgttt aataggtatt 2110441 tgccgttctt tttgattgct gttgtgcgga ggctcccggc atccgacccc gagtgaggct 2110501 ccgttagtgc aaatgcgccc aaatggtctc ctgacgcgag atttggtata tatttcatct 2110561 tctgttcttc gttgccgaaa tacagaatcg gattcgtgcc gactgaggta tgaacggaga 2110621 gaatcacgcc gacagccgcg ctgattctag aaatctcatg aattgccaaa atataagaaa 2110681 caacgtccgc tccagcaccg ccgtattgtt ccggcaccgg tattcccatc agtccgtgtt 2110741 tacccatttt tttgatcagc tgaaagggaa attcgtccgt tttctccatg atttccgcag 2110801 cgggagcaat ttcttttcgt gcaaaatcac gcaccatttt tcgcatcatg acttgctctt 2110861 gggttacatg caactcggcc acccccggat ggaatagact tcaggaagtc ttctcctcat 2110921 agtcataaaa accgcgtccg ctctttttgc caagccagcc tgctttgaca tacttgcgga 2110981 gcagcgggca aggacggtat ttggaatcgc caaggcctga gtgaaggact tccataattg 2111041 ataaacacgt atccagtccg ataaaatccg ctaatgcaag cggacccatc ggatgattca 2111101 tgcccagctt catcacttca tctattgcct ccggcttcgc cactccctca tacacgcaat 2111161 agatggcttc attaatcatt ggaagaagca cacggttgga aacaaaccca ggaaaatcat 2111221 tgacttctac cgctgttttc cccatctttt ccgctaatgc cataacatct aaggccgttt 2111281 cttctgatgt agccaagcct cgaatcactt ctaccagctt cattacaggg acgggattca 2111341 taaaatgcat gccaataacc cgttgaggcc ggtttgttac agcagcgatt tctgtaatag 2111401 gcaaggaaga tgtattgctg gccaaaatcg tatgaggcgg gcaaatgcga tcaagtgttt 2111461 taaacatctc agtttttgcc gccatgtttt ctgcgatagc ctcaatcaca atgtccgcat 2111521 gctctgcctc ctcaagtgtt tgagaaatcg aaatgcggtt gattacgctc ttcacttccg 2111581 tctcggtcct ttttcctttc tcagcatcac gggccagctg tttcttcagc cgtttcaatc 2111641 ctgcctccgc ggcctctgga ttcacatcat acatccgcac ataaaagccc gcgtcggcgg 2111701 ctgtttgagc aattccgctc cccatctgac ctgcgccagc taccatgatt tgtttgattt 2111761 ccattcaaat cccctttttc atcatgtttt aatgaacctg cactaagacg gcgtctccct 2111821 gtgctgcccc gctgcaaata gcggcaacgc ccagaccccc tccccgtcgc tttaattcat 2111881 aaacaagcgt catgagaatt ctcgcaccgc tcgcgccgat cgggtggccg agcgcgatcg 2111941 caccgccatt cacatttact ttttcaagat cgaaacctac gattttttca catgtcaaaa 2112001 caactgaagc aaaagcttca tttacttcaa acaagtcaat atcttggaca gttaaaccat 2112061 tctttttcag gagcttgtta atagcaaacc ctggcgctgc cgccagctcg tgcgctggca 2112121 ttcccgtagt tgaaaaacca agaattgtag ccagaggccg tttgccaagc tcagcagctt 2112181 tttcctcaga catcagcacg aacgcgccgg ctccgtcatt gactccagga gcattgccgg 2112241 ctgtgataga accgtcactt gcataaatcg gagcaagttt tgcgagctga tccagacttg 2112301 tgtcacggcg aatcgcttca tctttatcaa caacgtttgg ttttcctttt cgaccgatcc 2112361 agttgacggg aacaatttca tcctgaaact tcccttcatc ggcggcctta gctgcccttg 2112421 catgacttct caacgcccat tcgtcctgct ctcttcgtga gattgcatat tccttggcag 2112481 ctgtatttcc gtgaacagcc atgtgcacct cgtcaaatgc gcacgttaat ccgtcataca 2112541 ccattaagtc cctaagctcg ccgtccccca tccgtgctcc ccagcgcccg gcgggaacgg 2112601 catacggaat attgctcatg ctttccatcc cccccgcaac aagtatgtcc gcatcctgcg 2112661 cccgaatcat ttgatcacat aaagtgacag cgcgaaggcc ggaagcacag actttattca 2112721 gtgtttctga cggcacactc caaggcattc ccgccagacg ggcagcttga cgggaaggta 2112781 tctgccctga gccggcctgg acaaccatgc ccatgacgtt tccttctaca tcatctccag 2112841 agactccagc ctgttgcagc gcctccttca tcacaatgcc cccaagctca gcagctttca 2112901 cctctttcaa aactccgccg aatttgccaa atggagttct tgcagcactt acaatgactg 2112961 ttttcctcat ggtttcacct cattcagaag atagacagcg cttacaattt ctagttgtct 2113021 tctatgaatg tatgctttga aacgggcatg aatgaatgaa aaaagaaggc tgcgtcaaac 2113081 agcctccttc taacaactat tcatttttca gcaatgccga agccttttct ggaaagtcgg 2113141 taaacatgcc gtctgctccc gcttcaatga gacgcttcat atcttccgga cgattgactg 2113201 tatacggcct taccttaatc aaaccgttcc tcattttctt cagtacttca tctgtgaccc 2113261 ctgggctgtt tatcttcggg tgatagccgg aagccggaat agacgcgata tatcgatctg 2113321 cctgataaag cacatctgaa gttaatactg cccgttcgat atgcggtgca agccgggcgc 2113381 acagcgccaa gctgtcatga ttaaacgtgg ataggatgac tctgtcctct acattaaatc 2113441 gcttcactgc ctccagcact ttttcttcca ttccctcata gcggatcacg ctgtttttta 2113501 attcaatgtt gatgagaaaa tcctttttta ccgcccacga gagcacatct tctagcagcg 2113561 gcacttttat atcgctgtac gcttgatcgt gaccagcggc cgcattcgca gtctttacct 2113621 catcataggc tgtatccttc acgaatcctt taagtgatgt cgtgcgatta agtctttcat 2113681 catgaattac aacaatgcgt ccgtctttcg tcagctgtac atcaagctct atcccatccg 2113741 ctccggcttc aattcctttt tcaaatgcaa gcattgtatt ttcgggaaat tgacctgatg 2113801 ccccccggtg ggcaaaaatc tttgtcatcg tttcacctca aaccctaaag ttttctccat 2113861 tatacttatt ttgtcggctc cactctagga ttaaggctgt atcaatctac tgatcataat 2113921 aagaatcaat gccattgaca atcgcatctg cggccttttg ctggtattct tcacttccca 2113981 gcttgtccgc gtcagagctg ttcgtgataa acccaagctc cgccaacaca cttggcattt 2114041 gtgaatatgt aatgacgtaa aagtctgatt ctttcacgcc cctgtctctc gtttgtaagg 2114101 aagaaacgag ctgtgactga atatcggatg ccagacgccg gctgttctcc ccttcataat 2114161 cagattgaaa atacgtttct gttcctgaag ctgaagcaac ccctgaattc acatgaatgc 2114221 tgacaaaaag gtcagcctga ttggcacttg ccttagccac tctttcctcc aaggtcagaa 2114281 aatgatcgtc agaccgggat gcaacaggat tggctccctc ctcttttagt ttgtctgtca 2114341 catgctctga gacagccaaa ttaatatcct tttcaaagag cccgtttccg accgctccac 2114401 tgtcttcacc gccgtgtccg gcatcaatat acactgtttt cccttctatc ggctctgctg 2114461 cctgtgcaca aggcgcgagc gtcaaagcca atccgcacag cgccaagctc ctccataaca 2114521 ttctcaactt actccctccg gtcacgagtt ctttcgcagc tgaatatctt ccagctgtaa 2114581 agttccatta tccttctttg tatatttcac caggacatgt gtctgatctg gcagtgattc 2114641 acattcatca cgtttatcct tcggaacttg tatcatggtt tcttctccat taagagaaac 2114701 cgcaatcgta tgaggatcag ccgagccaat gtattttccc tcttcggtaa acctcggcac 2114761 tgagtcatcc gcacttgcaa cactgcaccc cgaaagaaag agcgcagtaa acagcaaaag 2114821 aaccgtttgt ttcacatgac cacctcttcc tgatgtttgg cttttatctt tgaccagaat 2114881 ggagaatttg taaagacaac gcgaatgcag gcgagcaagt tccatgattt tcaaaagggc 2114941 tatacgaccc gatcatttcc tgttgttaga aagataacga gcagatttgt ctatgaggat 2115001 ggctctaatt gaggcgccaa ttagaaaaaa ttagcggaaa gaagcaactt tttattcatt 2115061 ttaaaaaatt tgagaatagg gtgagcaaat cgtttgacgg gtgggtcagc caagcgtaac 2115121 cttttaaagg atatttactt tattgaaaga agttaaagcc atgaaaaaat tcgttctgct 2115181 gctggcggca gctgtcatca catgctccat cggccaccaa atcagtggcg gctacaaagg 2115241 ccccgaaaaa gagcggccaa aacatcactc tgcactcaag atattcagtc ggtaaagcag 2115301 atcaattgca ttaattttta catataggct agaatatgtg cgaatccaaa cgaaagaaga 2115361 tgatcaaatg aatcctaagt ataagccact ttttgaacca tttacgttta aaagcggcgt 2115421 tacaatcaac aaccggatcg cagtagcacc gatgactcat tacgcttcta atgaagacgg 2115481 tacaatatct gaagcggagc tcgactacat catcccccgt tcaaaagaga tgggaatggt 2115541 gattacagcc tgcgcaaatg ttacaccgga cggaaaagca ttccccgggc agccggccat 2115601 ccatgacgat tccaacattc caggtttaaa aaagttagca caagccattc aggcacaagg 2115661 cgctaaagct gttgtacaaa ttcatcacgg cggtattgag tgcccgtctg agctcgttcc 2115721 tcaacaggat gttgtggggc caagtgacgt gtttgataac ggcaaacaaa ttgctcgcgc 2115781 attaacagaa gaagaagtgg aaaacattgt gaaggcgttt ggagaagcga caagacgcgc 2115841 cattgaagcc ggctttgacg gtgtcgaaat tcacggtgca aacggctact taattcagca 2115901 gttttattct ccgaaaacca accagcgcac ggatcgctgg ggaggaagcg atgaaaaacg 2115961 attagccttc ccgctcgcta ttgtcgatga agtgaaaaaa gccgcttcag aacatgcgaa 2116021 gggtgcattc ttagtcggct accgcctgtc tccggaagaa cctgagacac cgggattgac 2116081 aatgactgaa acttatacgc ttgttgatgc tttaggggat aaagaattgg attatcttca 2116141 tatctcactg atggacgtga actcaaaagc gcgccgcggt gcagatccga ctcgcacacg 2116201 catggactta ttgaatgaac gtgtcggaaa caaagtgccg ctgatcgccg tcggttccat 2116261 ccattccgct gatgacgcgc ttgccgtcat cgaaaacggt attccactgg tcgctatggg 2116321 acgcgaaatt ctagttgacc ctaactggac ggtaaaagta aaagaaggcc gtgaaaagca 2116381 aatcgaaaca gtgatcaaag gcacagataa agaaaaatat catttgcctg aaccgctatg 2116441 gcaagcaatt gtgaacacac aaggctgggt gccttataaa gattaatgtg caaagactgc 2116501 cgaaacgatt cggcagtctt ttttcccttt atataaatag tttgtgtaca catctaaaca 2116561 gcaaaagaaa gagctcccca ccaacttcga aaagaaaatc caggaaaaac ccctcacgct 2116621 ttcttgcttt tttctttttc attcgtacgt ctccttttta catgaatacg ccttacttac 2116681 gattttgcag gagaaaggtt tcattttata acggacacat ctagggtcga tcatgcttcg 2116741 tgatcctata agatgtatga atggaccaag agtgcaggta ataccgccat ttgctttcct 2116801 tacttttcaa acctatcctt tactatatgc ggatacttaa tattcttctc ccatactaca 2116861 aatgtcccca aaacaaaacg cctcctattt atcagcgcaa actaataaat aaaagacgtt 2116921 tgatttaatg accacttaat aagctcatgt ttaagaagcc ttatgctcta acctcagctt 2116981 atccgcaacc attgcaatga attcactgtt ggtaggttta gcttttgtca tgctgacagt 2117041 ataaccaaac aacgaggaaa tggaatcaat gtttcctctg ctccatgcca cttcaattgc 2117101 atggcggatc gctctttcta cacggcttgc ggttgtgtta aattttttgg cgatgtccgg 2117161 atagaggact tttgtaatgc tgccgagcaa ttcgatgtca ttgtatacca ttgagattgc 2117221 ttcgcgcaga tagagatagc ctttaatatg ggctgggacg ccgatttcat ggataatgct 2117281 tgtgatgctc gcgtcgagat ttttcttctt tggttcaggc tggctgctgc gtataatact 2117341 gctttgcgat gatggcgcac gatgcgtcac actgctggca tttccgctga cctggcggat 2117401 atggccgaca aggttttcca tatcaaacgg tttgagaata aagtaggacg cgcctaaatc 2117461 gacggccttt ttcgtgacat cttcctgccc aaaggctgtc agcataatga cattcggctg 2117521 ttttttcaga tctgattccc tcagcctctc taaaaccgca agtccgtcta gatgcggcat 2117581 aataatatct aatacgagca catcgggatc tttttcttta aacagcgaca ggcattcctg 2117641 tccgttataa gcaacgccga tcacttccat gtcttcctgt ccttctatat attcacttaa 2117701 caggcttacc agctctcgat tatcatcagc aacacaaact ttaattttct ccacgtttct 2117761 tcctccccaa atgtagttaa caggattcac ccttgctaca tgtttacatt cgacaaaacc 2117821 gctatatacc ctctaaaaaa atcataatca ccaatattag tggcatatct ttgttattct 2117881 atgtttttct ctgtttttcg actaaaaatg aaatttgaca aacaaggaaa cgtgaatttg 2117941 tcgaaaaatc ttcttttgta tattttaccg tatgtattct gagaagtgaa gagggatcaa 2118001 aataaaaaaa ctgccggaaa ctccggcagt cagcttgctt tttcttttcc ataaatatcg 2118061 attcctgctt ctgacagcat ccattcaata tgaacaccgt agccgcttgt cgggtcattt 2118121 acaaatacat gggtgacagc accgatcact tttccatttt gaatgatcgg gcttccgctc 2118181 atcccctgta cgatgcctcc tgtttctttc aacagtcttg gatcggtaat tttcaacacc 2118241 attccttttg tcgcagggaa tttttgcggc gttgtgctga cgatttcaat atcgaatttt 2118301 tctactttgt catcatcaat aaccgttaaa atttcagccg gccctttttt gacttcggta 2118361 gaaaacgcaa ccggcaatgc ttgatctgat atgttgtttt gaatcggctg atgcagtgtg 2118421 ccgaaaatcc caaacgggct gtttctgtta atatccccga tcgttttgcg ttctgaggaa 2118481 aatcgcgcca gtttttctcc cggattaccg cctgtccctt tttcaattga tgttacagtg 2118541 gatttaacga tttctccatt ctccactaca attggtttct ttgtgtccat atcggaaatc 2118601 acgtggccaa gtgctccgta tttttttgtt ttcggttcat aaaaggtcat agtgccgatg 2118661 ccagcagcag aatctctgat atataacccg attctgtatt tgccttctcc ttcatccttt 2118721 tctgggatca gcttcgtttt gattttctgt ttatcacgtt tgatcagtaa gtctaaagat 2118781 tcaccagttt tcccagcctt ttgaataaat ggggctacat cattcatttt ttcaattttc 2118841 tgtccattca tctcaataat gatgtcgccc gcttcaattc ctgccgtttc tcccggagat 2118901 tttttgcctt cacttgtatt gatttgatga aatccgacga caagaacacc gacggaatga 2118961 agttttacac cgattgattg tccgccaggt ataactttta aatcaggaag aacatgcact 2119021 tttgtttttt taattggaaa tccggcaaga tcatatacca attctgactc acctgatttt 2119081 ttgcccgtca ccttgatttc atgcggatct ttctttactg taaacgcttc tgaggattct 2119141 gatgtctgag cgtttaccga taaactcgtt tcaatcgctt gtgtttgggt ttcaaatact 2119201 ctcatttgcg ttggaatcag taaatattct tttagcggtt tgcataaacc tacacttaat 2119261 aacgaaacaa ggagaattaa acctactgct tttctgatgt tatcgggcat tcactacttc 2119321 actctcctcg ctcctatccc acaccttctt tatgacttgc tgctacatca tttaattttg 2119381 ccttctgacg gcttatttat aactgtcata tgaagaaaaa cattggatat actgatgaac 2119441 gaatggatgt gcacgaaaaa aataagctgc gcttctcgcg cagcttaccc agttgttttg 2119501 acttgatccg cttgttttaa aagttctttc gcatggcgtt tcgttaagtc ggttacttcg 2119561 acacctgcaa tcatgcgccc gatttccgct accttttcct gcttagagag cggcttgaca 2119621 cgtgtcgtcg ttctgccgtc ttttaactcc ttcgcaatat aaagatgcgt atcggccatg 2119681 gcagccacct gaggcaggtg tgtaatgcac agcacttgtg atcctattga caccttatgg 2119741 atcttctcag caattgcctg tgcgaccctg ccgcttacac cggtatcaac ctcgtcaaaa 2119801 atgatcgatg tcacatcctg ttgtgaggaa aaaatgcttt ttatggcaag catcacccgt 2119861 gacagctctc cacctgaagc gactttcgaa agggatttca gcggctcgcc tgtattggtt 2119921 gaaattaaaa acttcaccag gtcaatccct tgttcagtca gctgaacggg ctggccgttt 2119981 acaagcggcg cctcttcatt gcgtgacgct gttctgacct taaattccgt atcaaaagtt 2120041 gatttttcca tgtacaggct ttttaattcc cgatgaatct catcagccag ctttttcgcc 2120101 catgtttttc ggatttgtga cacatttgcc gcttccactg cgacatcttt gccgacggag 2120161 tcaagctcct ttttcaagct ttgaaggtgg ctgtccctgt tttcaatttg gtcaatctct 2120221 tcttcaattt tagaagcata ttccaaaatg tcttcaacag tggcaccgta ttttcgtttc 2120281 agctgtttga tttcattaag tcgcgtctca atatagttca ggcgttccgg atcaaattca 2120341 agctcatcca gcatatttct catctgaaat gtggcatcct caagcaaata gtaggagttc 2120401 gaaacacttt cagacatttt tttcagcggt tcgtttatat cagatatatc ttcaagctgc 2120461 gctgatgcca ttccaaccca gtccaatccg ccctgctcac tgcgaagcgc gttatatgca 2120521 ttttgcagcg actcatatat cttctcaaag tttgaaattt gctggcgctc ttcttggagc 2120581 tgttcatctt cgttaagctc aagctttgcc gattcgattt cttcgagctg aaattgaata 2120641 agatcaagac gatgggccat ttcctgttcg ctttcagaaa gctgcttaag ctttttgagc 2120701 agcttcacat accgctggta cccttcctga tacgttttga gcgcgctttc cacttcggcc 2120761 ccggcaaact tgtccaaaag ctggagatga ttttcgtctt ccattaacag ctggttatcg 2120821 tgctgcccgt gaatatctaa taaaagcctg ccgatctctc ttagtgaagc aatcgtgaca 2120881 agcttgccat tgacacggca aacgcttttc ccgctcgtgc tgatatccct tctcatgacg 2120941 atcatttcgt ctgaaacgtc gattccctgc tcagcgcata cgcctaaaac aggatggccg 2121001 ctctccaaca gaaacagccc ttcaagttcg gcttttgctt ccccatatct aacaaattca 2121061 gatgatccgc ggcctccgac taaaagagaa atggcatcta tgatgatgga tttgccggct 2121121 ccggtttctc ctgttaaaac cgtaagcccg cgttcaaaag aaaccgtcag ttcctcaata 2121181 atggcaaagt ttttaatcga tagttcagct aacaaacagc attacacctc ttatctttgt 2121241 tagattttct gttacagcag ttcaaggagc ctgtttttta cgccttctgt atcttcagga 2121301 gtccggcaaa taattaaaat cgtatcatct ccgcaaatgg tccccatcat ttcatcccag 2121361 tccaaattgt ccatcagcgc cccgattgcc tgggcattgc ccggcatcgt tttcagcaca 2121421 atcatatggc ttgctgagtc tattttcaca aatgcgtcca tcaatgcccg ctttagcttt 2121481 gacagcggat tgaaacgctg gtccgccgga agactgtatt tgtaagaacc attatttgta 2121541 ggcactttta caaggtgaag ttctttaata tcccgtgata ccgtggcctg cgttactttg 2121601 tatccatcct gctttagcat gtcgaccaat tcatcctgcg tttcgatttc attgcttgta 2121661 atgatctctc tgattttaat atgcctctgg cctttgttca tgtaagcacc tctatttcca 2121721 agcttatctg ttcttttatg ttatatgatt ctctgcacat tgtacatgaa tgcagaaaaa 2121781 aggaataata gcgccctatt attccggtac atctgctttt ttttctttta acgtcttatg 2121841 tgcttcttct acaacgcgca tgatctcttc ttccggcagt tcctggcctt cctgtccctc 2121901 tcccggccaa tgcaaatgaa ggagaaactc aatatttccg tctcctcccg tgattggaga 2121961 aaatgacaag cctttacaga tatagccttc agcggcagaa aaactgatca ttcgcttgag 2122021 cacatcagca tgcactttag gatctctaac aatccctttt ttgccgacgg attcccgtcc 2122081 cgcttcaaac tgaggcttaa ctaaagccat gcagtcgctg cccggtacga gcaaagtcct 2122141 taggacaggc aggatgagcc gcagtgaaat aaaggacaca tcaattgtgg caaactccgg 2122201 catgcccttt gtaaagtctg ccggtgttgc ataacgaaag ttcgtccgtt ccatcacgac 2122261 gacccgttca tcctgtctaa gcttccatgc aagctgatta tagcctacat ccacagcgta 2122321 tgactgttta gctccatttt gcaaagcgca gtccgtaaaa ccgccggtgg aggagccaat 2122381 atcaatcata attttatctt tgacagagac gggaaattcc ttcaacgctt tttcgagctt 2122441 taagccgccc ctgctcacat acctcagcgg gtttcctttg acagttaacg gaaggtcgcg 2122501 gtcaattttt tctccaggct tgtccaagcg gttttcgttt gaatagacga tccccgccat 2122561 aatggctctt ttggcttttt cacgcgtttc cgccagccct ctttccacta ataatacatc 2122621 taatcgttct ttctttgacg tcatgatcca attcctttgt gtgtctttgg tggcatcagt 2122681 aatctaatac gatttgccac ctgctgtttt gtcagtccaa tttcctcaag aagcgctgtt 2122741 acacttccgt gttcaataaa ccgatcaggt atacccattc tgtcaatcgg agtatgatat 2122801 tcaccttgat catgagcgaa ttctaaaatc gagcttccga aaccgccttc taagaccgct 2122861 tcttcaattg ttaaaattgg caagccttct tttaggatac tcttcatcat cttttcatca 2122921 atcggcttaa taaaacgcgc attcacaacg cgcacggaaa ggccttcttt ctgcagctct 2122981 tcggctgctt caatcgccat ttcgattgtt gtgccgaatg ttaagatgac agcatcgttc 2123041 cctggacgca gcacctccca cgtaccgatc ggaatcgttt tcaactgttc atccattttt 2123101 acgccgagtc cgtttccgcg cggaaaacgc attgctatcg ggccttcgtc atagctaagt 2123161 gctgtatgaa ccatgtgctg gccttcattt tcgtctttcg gcatcattaa gaccatgttt 2123221 ggaatgtggc gcataaacgc aatatcaaac acgccttgat gtgtctctcc atcagcgcca 2123281 acgagtccag cacggtcaat tccaataaac acattagcgt tttggcggca gatgtcatga 2123341 acaacttggt catatgccct ttgcaggaag gttgagtaaa tcgccaaaaa cggcttcata 2123401 ccctgcattg ccatagctgc agccattgtt gcggcatgct gttctgcgat tcctacgtcg 2123461 aacatccggt cagggaattc ctttgcgaag ccttcaagct ttgaaccgac aggcatagcc 2123521 ggcgtaatgg ctacaatgcg tccgtcctcg cgcgccattc gctgcacagt tccgctgaca 2123581 agaccgctcc acgaaggagc tgcggctttc ggctttacaa agtcaccggt attaatttta 2123641 tatggtccgg taccatgcca tgtcccaatc gtatcggtct cagccggttt gtaccccttc 2123701 ccttttttcg taatgacgtg cagaagaaca gggcctttcg tttttttggc gtattgaaga 2123761 ttctcaatca gctcatgata agaatgtccg tccactgggc ccaaatacgt aaaaccgagc 2123821 tcctcgaaaa acattccgga gacgagcatg tatttcaggc tgtctttgac ccgttccgcc 2123881 gtggcggcaa gcttgccccc aactgccgga atctttttaa ataagtattc aagctcatct 2123941 ttgacccact ggtatttccc cgcagtgcgg agccgtccga gcatagagtg aatggcaccg 2124001 acgtttggcg caatactcat ttcattatca ttaaggatga caatcatgtc ttttttctcg 2124061 tcgccgatgt ggttaagggc ttcgagcgcc ataccgccgg tcagcgcgcc gtcaccaatg 2124121 atcggaataa tatattcatc cgttccttta atatcacggg cagctgccat tcccatcgcg 2124181 cctgacagag aagtcgagct gtgcccggtt tcccaaacat cgtgctcgct ttcactccgc 2124241 tttggaaatc cgcaaagccc tttgtactgg cgaagcgtcg caaattcttt tccgcgtcct 2124301 gtcagcagct tatggacata cgactgatgg cctacatccc ataaaaattt gtctttcggg 2124361 ctgttaaatt ccttatgcag ggcaacagta agctctacga cacctaagtt tgggccgatg 2124421 tggccgccgg aagcggataa acttgtaatt aaaaactgac ggatttcatc acttaatttc 2124481 tctaattcat caatggacat gttttttaaa aacgacgggt cctgtattga taaaagatcc 2124541 aaagcggatc aactcacttt cagcatgaat ttctgcaatg atacatgtct tttgcatgcc 2124601 gagctgacaa taatctcaga cataaaaaaa gacaaacgcg cttttccttt tcatttttca 2124661 tataaactgc ttacatttta ccatacctcg tgcagccgct tcaaattagg atcgttttag 2124721 tgatctcttg ccgcaattaa atcacaaagc tcatataaaa ggtctttttg aagagagagt 2124781 ccgccgatca atcgcttcgc ctcttttata tgaacatcca atttatgttt ggccccttcc 2124841 aatgaaagaa gcgacgggta tgtcgatttg tcatttgtgg tatccgagcc gacacgtttg 2124901 ccgattttct cttcactgcc ttctaaatct aaaatatcgt ctctgatttg aaatccgatt 2124961 ccaatgtggc tgctgaaggt acgcagtgtt tcaatgtctt cctcaggcgc atcagccaaa 2125021 atagcaccgg cgattacaca aaagccaagg agcttggcag ttttccgttc atgaatggat 2125081 tcgagctctt caagcgtgac ttgtcggttt tccgcttcca tatcagctac ttgcccaccg 2125141 accatgcctt cggtgcctgc cgctgaaatc agttcattca caagccgcag gcgcttttct 2125201 gctgacacct cgtctgacac gtgggaggta atcagcttaa agctttctgt gagcagcccg 2125261 tcacccgcta atactgccgt cgcttcacca aacactttat ggtttgtcgg cttcccgcgg 2125321 cgcaaatcgt catcatccat gcatggaaga tcatcatgaa ttaacgaata cgtgtgaatc 2125381 atttcgacag cacagcccac cggaatgccg tctttttcgc tttttccata tgcatttaaa 2125441 acagccagta caatcagagg ccgcaaccgc tttccgccgg cctgtagaga atatagcata 2125501 gatttcttta atgagtccgg catatcaagc ttttctgtat agacagaaag ctgattttca 2125561 attgtttttt tccggtccgc cagaaagctc gttaatttat ttgtcacctt cgtcttcctc 2125621 ctgaacactg aaaggtgcca gttcgccgtc ttcttttaaa atgaagtcca tttgcttttc 2125681 gactttttgc agcttttcat ggcacatttt tgacagagcc atgccttctt ggaaatagtt 2125741 aatggcttgc tctagaggca catctccctc ttcaagcttt gatacaatgc tctcaagccc 2125801 tttcatcgct tcttcaaatg tcatgttttc attttttttc acgtctgtca tttttcttcc 2125861 cctctctttt ctaatacttc acaggtcagc acgccatcct tcagcttgat ttcaagccgg 2125921 tcctgctctt ctatttgact gacactttta atgagtttat cttctttata agccaagctg 2125981 tatcctcttt ccatcacttg aagaggactt agtgcattca gcttgccaag aacggtttga 2126041 aattgggaat gcagctgctt catttggata ttcatatttt ttctcagctg atttgtttgt 2126101 tcctggtatc gtgttctcgc ttgtttcagc tgttcatgag gatgcaatgc ctctaatctg 2126161 tacgtttcac gctccagctg tctgcttttc cgatctaaaa gagcggtcag ctgtgcttga 2126221 aactgctggt acgcgaggtc aaactgctgc tctttttgcg catacaaacg ctttggaaaa 2126281 cgaaaggcat aggacgattg cagcgtttgt atccgttctt ttttctggcc gagatgctgc 2126341 tgcattgctc ttgtcattct gacttccgct gtttttgtcc gttcgattaa atcagtggta 2126401 tgaggcacag caatctcagc tgctcctgtc ggcgtcgcag ctctgatatc ggcgacaaaa 2126461 tcactaatcg taaaatccgt ctcatgtccg actgccgata taatcggaat attggaagca 2126521 aagatggcgc gtgctacaat ttcttcattg aatgcccaca gttcttctat cgaaccgccg 2126581 cctctcccga caattaatac gtcgcaaatc tctttttcat ttgcctcttc aatgcgcgta 2126641 acgatggatc tgctcgcatt ttcaccttgt acgagcgctg gaagaacaat gacttttaca 2126701 aggggatatc ttctttttag agttgtaata acgtctctga cagcggcacc cgttggagat 2126761 gtcacaaccc cgattgtggc tggaaatgcg gggatttgtt ttttgtagcg gtcgtcaaat 2126821 aaaccttctc cggcaagctt cttttttaat tcttcgtacg ctaaataaag cgctccaacc 2126881 ccgtcaggct gcatttcttt ggcatataat tgatagtttc cgctcggttc atatacggaa 2126941 attccgcctc tgaccagcac tttcattccg ttttcaggtt taaaaggcag acgctcgctt 2127001 tgtctcgcga acatcaccga ctgcattctt gcgttttcgt cttttaaagt gaaataaata 2127061 tgccctcgtg tgtgtatctt tacattcgac aattcgcctt taatccaaat attttcaagg 2127121 tgaggatcta catcgaattt tcgttttata tactttgtca gcgctgagac ggtcacatac 2127181 gctgcttcac ccatgtctaa aaactcctct cctaagcatt cctgcaccat aactaaagaa 2127241 aacccgccct ggctttagga gcctgaagaa gcgggtatcg tgctcatatt caaggcgggt 2127301 aaacatttcg cctgtgaata tctccaatta tctatgataa cgtacgtttc gcagatttaa 2127361 cagtattatg cgcaagcatc gtgatggtca tcggacctac tccgcccgga accggcgtta 2127421 tgaaggacgc tttttccttt gccccttcaa attcaacgtc tccgcaaagc tttccgtttt 2127481 ccagacggtt aacgccgacg tcaatgacaa cagcgccctc tttgatctgg tctgcactga 2127541 tgaagttggc tctgccgact gccaccacca ggatgtccgc ttttttcgta tgttcagtaa 2127601 tattttctgt tcttgaatga cagtaagtaa ccgtcgcgtt ttcatttaat aaaagctggc 2127661 cgacaggttt gccgacaatg ttgcttcggc cgactacaac aacctcttta ccggaaaggt 2127721 caatattggt tttcttcaaa agctcaacaa ttccatgagg cgtgcaagga agaaacgtat 2127781 cttcgccaag cagcattttc cctacgttta acggatgaaa accgtctaca tctttatcag 2127841 gggagatacg ttcgatcacc gctttttcag aaatatggtc tgggagcgga agctgaacga 2127901 gaatgccatg aaactcaggg tcttggttat attgatcaat aatggaaagc agttcagctt 2127961 ctgtgaggct gctgtcaaat tgatcgagct tgaaattcat tcccattgtt tctgccgctt 2128021 ttttctttcc tcgcacgtaa gagtgagaag caggatcatc tccaatcaaa ataaccgcca 2128081 gtccgggagt gacgccttgc tttttaagct cttctacctc ttttgccaat tgttcgcgtt 2128141 tttctctagc cgtttctttt ccgtcgatga ttgttgcagt cattttcttt cctcctatga 2128201 ttgttcaata tcagatttaa tgttagaaag aaccccgttt acaaactttg tcgctttgtc 2128261 atcaccaaac cgttttgcca gctcaatcgc ttcgttcatg gagacattca ccggaatgtc 2128321 ttcggcatat gccatttcat atgctgccag gcgcaaaatc gcacggtcaa cattggcaat 2128381 ccgatcgagc ttccaattca ccagatgctt ggagatcatt tcatccagct ggtcttggtg 2128441 ttccaatacc ccgtgtacaa gctgttcaaa gaaaggatct gttttttctt catccagtgc 2128501 gtgttctatg gcttcattca ctgcaatatc gctgacatca atttgaaata gtgcctgcaa 2128561 agctttttct cttgctgttc ttcttttcat tttctttctc ctttgatcct ctttatccgc 2128621 ttgtcgttaa gccacaaaga gatcataaca tatttttttc gtatccgcat attgaaatca 2128681 aggttttttt accctattac cgaatatttt cacacacctt aatatgatta ttcggatttc 2128741 acgttcatga agaaactcgg ctatgtaagc cggctttctt catgctttga aataaagggt 2128801 aacgtgtaaa aaaaccaaag ggccgccctc cccttggttt cgtgttaagc catttacatt 2128861 tcttcgtcga tttggacttc ttgggctttt gtgtcaaatt gaatgccgac gatgtgaata 2128921 ttgatctcgt taatcgaaag agacgtcata tttaataagg tttgacgaat gttttcctga 2128981 acggatgctg caactttcgg aatcgaaacg ccaaatgtaa cgacacagta tacatcgatc 2129041 gtaattccgt catccgccag gtcgactttg acacctttgc catgattcac tttgccaaag 2129101 cgctcaacga cgcctgtcgc aaagtttccg cgcatttcgg caactccatc aacttctgat 2129161 gctgcaatgc cggcaatgac ctcaatgacc tccggtgcaa tctcaacctt acccaaatgc 2129221 gtatcttcgt gatccatttt aagcaagctg ttgtctttca ttcaattcac ctccgtaaaa 2129281 attatgagcc cattacatca tatgtttcta aaaatttcgt attaaactct ccgctcacaa 2129341 atgtttcgtg ttcaagcagt tttaaatgga aagggattgt tgtctcaatg ccttcgatga 2129401 cgaattcgct caatgcgcgc ttcatgcggg caatcgcttc atctctcgtt tttccgtatg 2129461 tgattacctt tgcaatcatg ctgtcatagt acggtgggat ggaatagcca gggtacgcag 2129521 ctgaatcgac acggacacca agaccgccag gaggcaggta cattttaatt tcaccaggtg 2129581 acggcatgaa atttttgctt gggttttctg cgttgattcg gcattcgatg gcccagcctt 2129641 caaattcaac atcttcttgc ttgaggctca gttccattcc tgaagccact ttgatttgtt 2129701 ccttgatcag gtcagttccc gtcaccattt ctgtgactgg gtgctccacc tggattctcg 2129761 tgttcatttc catgaagtaa tagcgctgtt cattgtagtc atagataaat tcaactgttc 2129821 cagcacctgt atagccaacc gctttggcag cctttaccgc tgcatctccc atttgctccc 2129881 tgatttctga atcaagggca ggagatggtg attcttccaa aagcttttgc aggcgtcttt 2129941 ggatcgagca gtcgcgttcg cccaaatgga tcgtatttcc gtagttatca gcaagcactt 2130001 ggatctcaac gtggcgaaaa tcttctatgt atttttcgat gtatacacct ggattcccaa 2130061 atgcagttgc cgcttcctgc tgtgtaatct taatgccatt aatcagttcc tcttcagtgc 2130121 gggcaaccct aattcctttt ccgcctccgc ctgcggtggc ttttataatt acaggatacc 2130181 caatttcatt agcaagcgaa accgcttctt ccacattttc tataattccc tgtgaacccg 2130241 gtacgattgg cacgccggcc tgtttcatcg tttcccgcgc aacgtctttt gttcccattt 2130301 ttgaaatggc gtcagcgctc gggccgacaa acgtgacatt cacttcttca cataattcag 2130361 cgaaatcagc attttcagct aaaaatccgt atcccggatg aatggcgtcc gtgccagtca 2130421 gctttgcaac actcacaata tttgtaacgt ttaaatagct gtcttttgat gctttcggtc 2130481 cgatacaaaa agcttcatcg gccatttgaa catgaagggc atctttatca gcttctgaat 2130541 aaacagcgac agtctcaatt ccgagctctc tgcaggctct gatgattctg acagcaattt 2130601 ctcctctgtt ggcgatcaat agctttttaa tcatgttcag tctccttact ccgcttttac 2130661 aagaaataga ggttgtccgt attcgaccag ctggccgttt tctactaata cttcaacgat 2130721 ttcgcctttc acttctgctt cgatttcgtt gaaaagcttc atcgcttcta caatgcagac 2130781 aactgtgttt tcatttactt ttgaaccggc tgttacatac gggccagctt ccggtgatga 2130841 agaagcataa aatgttccta ccattggtga agtgatttta tgcagattct catcttgctt 2130901 tggtgcttct tgggcaggtg ccgctgcttg ctgcgcttgc ggctgaactg cctgcggagc 2130961 ctgtgcttgt acaggtgctg ccggtgcctg ctgcatgact tgaaccgtgc ctgcttcgtg 2131021 ttttttcagt tttaaggata caccttcatt ttcatatacg aattcgtcaa ttgtagactc 2131081 gtcaattgct ttaatcagct cgtggatttc tttgatattt aacattcaat cgcactccta 2131141 tgtatgaaat ttcttttttt ataggttact actaaaagta catactatgt tcatcttaca 2131201 ggagcggact tttgaattca actctaatat gacagcaacg caaaaagccc gcttgtttag 2131261 cgggcttttt tccctcattc ttatttagag ggttcaaatg tgacagcgac atctttcatt 2131321 gttttgattt cttttgccac aaggtctata atggctgtcg ccttcgattt agagtgtttg 2131381 tctgatttga ctgtaatatt gattttatct ccttcagcat taacaagcgc atcctcgtaa 2131441 ccttgtgttt taatcagcgt ttccagctgt ttttctgttc cttccacttc actgagagcc 2131501 gtcattttat cgtatgcttc gcttttctcc ttggctgttg catcatcgct tgacacaatg 2131561 gcattcagct cttctctttc tttgcttctg gcatcttcta aatcaagacg gtacgttgta 2131621 aacaaatcat catcggctgt ttccgtaaca acagttcctt tttcactggc ttcagcggat 2131681 gtttccttgt ctgctgatga atctttcgtt ccctttgttc catcttcttt tcctttttca 2131741 gtttctgtac cgcttttttc cttcgtgtct tgcttggcag gcgctttttc agttgcgacc 2131801 tctccgctgt cagacgcgct tttttcactt tgcatctgca cggcgttttt gctttccggc 2131861 gacatgatat agtagacgct taacaccacg acaagactga gcattgttaa tagccaaacg 2131921 gtttgttttt taagcattta tgaatcctcc tttatttttt taggggcaac cgcaacccgg 2131981 tggcttggaa catccaggac ccgtgtcacc gcttcgataa tggtttgttt tatttgaacg 2132041 ttgtccactc cttgagcaac aacgagtaca ccgcgtatat caggtttttt cgtttggacg 2132101 acgacaggtg tttctttatc gccgtttttg atcatgacga tttcttcctc cgatgattgg 2132161 tctgtaacgc ttctttttcc gccttctttg tcagtttctt cagtggttgt atttttgttt 2132221 gatttgtttt tttcgtatac tttcagcgac gttgcatcta cattcacgac aaccgagaca 2132281 tcgtccacac caatgattgt ttcaagaatt tctttcagtt gattttcgta ttctttttca 2132341 tagtcatcga tcgagtcttt aggtttatca gattttgagg ctttaaacac ttcggctgtt 2132401 ttctctttgc tgtctgcgga atgttgtgat gatacggccg ttatcgtttt ggcgttttca 2132461 gttttctcag gtgaagaaaa cagctggctg acaagcataa aggaaactcc gagaacaaaa 2132521 acgaatagaa agtaatgata tttggtcagc ttcggctttt cgccgtcctt cgtttgtccc 2132581 ggaagaaact gctttttcaa tacattccat aatccgtttt tattcattgc cgacactctc 2132641 cccgccttcc atatgaaccg taattttctc acttccgatt tcccaaatgt ccgcgagctg 2132701 cgtttgtatc tgtttggctt ctttttgttc ggctgcttct tttgttacgt atgcatgatc 2132761 tgtatcaatg tggaccggcg cgaccgtttg gaccgttttt tcagaagacg gggccatata 2132821 cacgctgatt gttttaatat cctcttctga atctaccttt tctcctgccg tgagtttgat 2132881 gcggcctact ttatattcat catgactgaa tctctcctcc gctttctttt ttagttggac 2132941 agccatttct tctagaatat atgcgcgctg ggaagcttgt atttctattt tttttgaatt 2133001 gatttgattt tttatgtcgg cagactctga ctgcccgttt tttgtgaggt attcaaagat 2133061 gacttcgggg tctgtcttga aaagtttaaa aatcggcgta agcatgacga caatcaagag 2133121 caggctgact accatttttg cgtacttttg catgctggag ctcggcagca gcatatcaat 2133181 cacaattgca aataggataa acaacacgat ggtggtaagc cattccgtta aaaaactcat 2133241 ttgcctgcct ccttcatttc atcatcatcg tgaggtttcc ggctgtgatt atgacagtaa 2133301 ggcttaaaaa aaacatgaga gacacaatgg cgagagctgc aaaaatataa atgacgcttt 2133361 tgctgatgac gtcgaggcag gtgatgacgg gcccgcctcc tagcggctga agaatcgcgg 2133421 ctgccagctt ataaataaaa gcgagggaaa gcactttgat tgccggaaat gccgcaatac 2133481 agatcaaaat agcgacaccg agaatcccta ccgtattttt cagcagtaaa gaggcgctga 2133541 ttactgtatc tgttgcgtct gtaaacattc ggccaagcac aggaataaaa tttccggtta 2133601 taaatttagc cgtcctgagc gtaatgccgt ctgtcactgc agctgacgct ccctgaacag 2133661 agatgacgcc gagaaagatg gtaagaaaaa cagccagtgc tccgatggcg atatttctga 2133721 gcaggttagc cagctgcgtt actttgtatt gttcagtcat cgtgctgaca atgctcagaa 2133781 tcgctgataa aaaaatcagc ggcatgacga tattctgaat caagagaccg ctcgtgttca 2133841 tcaggaagag gataacagga tgaaagaagg cagcagatac agctccgcct gaggaagcca 2133901 aaagcgccaa gaggagcgga atgagcgcca ggataaagct ggtcatcgtc tgaatcgcct 2133961 cagttgcata gttaattgcc acatgaaagc tattaagcgc aaggataatc agcaccatgt 2134021 acacaattga gtaagcgacc ttactgacgg tgctttgctg aaaagcattt tgcaaaagct 2134081 gcagaatgac gcaaaaaatc gtgagcaaaa tcaatgtgcc cagcagcttt ccgttggcaa 2134141 gcacttcatg aaacaaataa gaaaagagag ctttcagcca ttcttgcggt gagaatgatt 2134201 tatcgccatt gataaactcc attaagctgc ctttttggct ttccggcagc agtccgccgt 2134261 attctgtcat aatgtcattc caaaattccc cgatcttatc tgtttcaagc gaggctgctg 2134321 tcctttccgc taattgctcg gctgtttcag catggtcttc cgtttgttct gcattaccag 2134381 ctgcttgtac aatttctgca cggcctgcta tgatcagcac ggccaaaagc aaaacccatt 2134441 gaaagcgctt caatctaccg cctcctttcg gttatgacat agaaggtata agtccgagaa 2134501 tcgtttcgat aatgacggtt aaaataggca cagccattac gagtattaaa attttccccg 2134561 ccaattctat tttcgaggcg atggctcctt gaccggcatc ttttgtgagc tgtgccccga 2134621 attcagcaat ataggcgatt ccgataatct ttaaaatggt ttcaacatag accatgttga 2134681 catttgcatt aatcgcaatt ttttctatca ttcgaataat gtcgtagatt tggtctacca 2134741 aataaagaaa aatggcacat ccggcaaaaa cgacgattaa aaacgcaaaa gtcggctttt 2134801 gttcttttac aattaaagaa aggaaggtgg cgatcagccc taaacctaca atttgaacaa 2134861 tgtcaatctg caagcccccc tatccttgga ataaaaacac agcttttatc tttttaaata 2134921 ggtcatctac aatcgtggcg accataaata aaatatagat aaaacctaac agcgtcaccc 2134981 actgagcata ttctttcttg cccatctgat ccaatatcgt gtgtaaaaaa gcgaccacga 2135041 ttcccactcc ggcgatttga aatatgacat tcacgtctac tcccatttta tttttgctcc 2135101 cctcacgttt acatcaatag aagaatgagt aacaagcccg ctaaaaagcc caaacttttt 2135161 atcatctttt cgtttttcgc ttgcgcctgc tcagcatccg cttctgaggc ttccaaatgt 2135221 gtcagcgcca gcttgatgtg cttttgctga gagattcgat catgaatccc aagcgtctcg 2135281 ccaaactgct tcagcacttc gtattcgctt tttttcaaag acagggtgtc ccataccttc 2135341 tttaagcttt gctcccacgc cgttttcgcg gaatcacttc ccttgtccag ctgatcactg 2135401 aatgcggaaa aaagagttga aacaggctgt gcgagctgtt tggcaatctg ctgtgaagca 2135461 gtatgaagcg gtgtatggcc gtacatgatt tcagcctcga gggattgaag cgccgcacgc 2135521 agctggcgga tttgccgcgg ccgttctgta taaatcttcg ccatctcaaa acctgtccat 2135581 gttgtcgcta ccacaatgaa tacagcgccc agcagcttca gcatgttttc acgcccgtcg 2135641 tcctagacag cacatttccg tctttgtcat aaatttggct cactgtgccc ggcccttttg 2135701 ctcttgataa ttccaaatag cggtcaaagg ctctttcttc ccacaaacgc ttcaatgaag 2135761 gccgcttcat caggtcggat atactccagc catgcgccga tacgattact gaaacaccgg 2135821 catgcagcgc ctccagaagt gcatctgtat cttccatacg cccgatttca tcgacaatca 2135881 tcacctcagg gctcatggat cgaatcatca tcatcagccc ttcagctttt ggacaggcgt 2135941 ctaacacgtc aattctctga ccaaattgat gctgcggaat accgcgaaga catccggcaa 2136001 tctctgaccg ttcatcgacg atccctgtct ttacgggcag catgtttttt ttgccggtgc 2136061 ttgagagcct cgcaaggtcc cggagaagtg ttgttttgcc ggtttggggc ggtccgataa 2136121 tcagcgtatt cagccagctg ttttgatata agtatggaag cagcggctcc gcaatcccca 2136181 gcttttgccg ggcaattcgt atattaaaag atgcgatgtc acggaggcct ttcacacctc 2136241 cgttttccgt aatgactctg cccgccagtc cgactctgtg gccgcctctg atcgtgacat 2136301 accctttctt cagctcttct tcaagtgtat acatactata gttgctgagc cggctcagga 2136361 tcagatgggc atcctcggcc gtgcccgcat aggacaaata aacaggttgt cctcttcgaa 2136421 tcaattcaac agggcggttg atccgaattc tgacttcttc gatttccagc cattgttgtt 2136481 ccggtatttc agaaagggcg tttttcatgg attcagggag aacctcagcg atttcattca 2136541 acagagcctc ctcctttcta ccgattggct tctttaaaat gtatgatgtg aggcagactt 2136601 tatgacaagc ctctctttat ttatgaacac ccgccaaaat caagacaaca cccgtaaaaa 2136661 tcagaatcag ctttgcatac gaaagctgcc cggcaatttg gtagattccg acagtcattg 2136721 taatgataaa aatcaacgga ccgacaatag cgagaatgct gttaaccaca accgccttcc 2136781 ggacatcgtt ggtcacaagc atgacaattg ctgccgtcag ctcaatcata gaggataaaa 2136841 ctcgtaatcc cgccattgtt aaaacagtag aattgatatt tccaagtaaa aatttcatag 2136901 cactctccca acctcccatt tttttatatg atatgctcta gcttgctgaa gtagtcttgt 2136961 cattttcgta taaaagaaag attctgtttt tgggcacaaa aaaagcctgc tcccatttgg 2137021 gaacagactt ctttttttct ttctatgctc ttgaaacgta agaaccgtct gatgtattga 2137081 caacaagtgt gtcgccttca ttcacaaaga acggcacgtt tacaacaagc ccggtttcag 2137141 ttttcgcagg ttttgtaccg cctgacgctg tatcaccttt aataccaggt tcagtttcaa 2137201 caactttcag ctcaactgtg tttggaagtt cgataccaag tgtttcatcc tggtacatca 2137261 tgatatgcac agacatgttt tctagcaggt attttaattc ttcttcgatt tgagttgcgc 2137321 tcagttcaag ctgctcataa gaagaagtat ccataaatac gtgctgatct ccgtttgcat 2137381 atagatattg cattgttttg gtttcgattt gcgctttcgc tactttttca ccagcgcgga 2137441 atgttttttc ctgaatcgcg ccagtgcgaa ggttgcggag tttagagcgg acaaatgccg 2137501 caccttttcc aggttttacg tgctggaagt caacgacgcg ccaaatgccg ccatctactt 2137561 caattgttaa tcctgtacgg aaatcgttaa ctgaaatcat gtttaatgtc ctcctatatt 2137621 ccaatcacaa aataataagt tcttttgggg aatgggtgat tgtccggttg ccgttttctg 2137681 taatcacgat gtcatcttca atgcggacac cgcctgtttc tggtatgtaa atgcccggct 2137741 ccactgtgac caccataccc ggttcaagga tagctgaaga tctgacggat aatcccggcg 2137801 attcatgaac ttccatgccg agcccgtgcc cggttgaatg gccgaaatag tcaccgtagc 2137861 cttttgcagc aatatgatcc cttgtgaggg cgtcagcctc ttttcctgtc attcccggct 2137921 taatatgtgc gacgccaagc gcctgagcat caaatacaac ctgatagatc tccttcaatt 2137981 gatcactggg ctgacctaca gcgaccgtcc gggtaatatc agaacaatat cctttataat 2138041 aagcgccaaa atcaagcgta acaaggtctc cgctttcaat cagtttgtca ctggccacac 2138101 cgtgcggaag gcttgaacga aggcctgagg cgacaatcat atcaaaagaa gagctgtctg 2138161 ctccctggct tctcatataa aactccagct cattggcaac agcgatttca gaaatgccgg 2138221 gtttcataaa cgtcaagata tgtctgaagg catcatctgc aatcttcgca gcttcctcta 2138281 atatcttaat ctcttcacta gacttaatca agcgcaactt ttccacggat tcagccacag 2138341 gcactaattc ggcatcactg ataacggcgc tgtatgaagc gtaagtgcca tatgtcatgc 2138401 tgttctgttc aaagccgaga cgcttgatgc caaacgattc aacagtgtcg gcagtggtct 2138461 gaatcaagct gccgccatgt tcaatgatct caaaaccctt tacctgaacc ttcgcctgct 2138521 cagtataacg aaaatccgta ataaacgctg ctttgtcacc cgatataaca gccaaacccg 2138581 ccgaacctgt aaaccctgtc atatagcgta cattagtgtt gcttgtaatc agcatgccgt 2138641 caattcccag ctgtccaaac aggtttctta atttctctag cttcatcttg attctccccc 2138701 ttgctggctt aataagtagc gaacagcaag cttgtagcct tcagctccaa gaccgacaat 2138761 ctgccctttc gcaacaggag cgataaccga ctgatgcctg aattcttccc tggcgtataa 2138821 gtttgataaa tgcacctcta ccacaggaag actgatgctt gaaacagcat ccctgatcgc 2138881 atagctgtaa tgactcaggg cgccggggtt cagaacaatc ccgctgtatt gctcctcagc 2138941 ctcatgtatc gcatctatca aatcaccttc gtgattagac tggaagaaag tgagctggat 2139001 atgtaaggct tcagcaaact gaaaaagatc tgtttcaata tcggtcagtg tctggcggcc 2139061 gaatacttca ggctcacgac tcccaagccg gttaacattc ggtccgttca aaatcaaaaa 2139121 atgaggcaca caatctctcc ttttcgcgag ggtttctcat gtaaaaaatg ttcacttctc 2139181 gtgaacattt tatcatactg gaaaaggatt atacactatt ctctatgcat tcccagcgca 2139241 cgtgcaagct tttccgaatt cagctcattg tattcaaatg aaatagaata cccgacaaac 2139301 agcccgtaaa gcaaataaat gcaaatggtc gtaataattg tatctgatgt cagttcggtc 2139361 accgtgcgca catctggaaa aatcggatta aaaacaaaaa acacgagcag ccaaagcacc 2139421 aagccgtata aaatacccgg ccacattgtt tttaaacgtt tcaatagaag aaaataaaga 2139481 aatgctgcgc caattgaaat tactccaatc aaaatgatgc tgattaccgt tcccagccca 2139541 tgttttttcc actctccgag tacaaacggc tgcaatatca tattcgggct gatttcggaa 2139601 aaatgaaaca aatatgcgat ataagcaacg aaactccaaa gtacgcctcc gcaaaaacct 2139661 gttgccgcca ccctgccggc cattgaaaca ggcggctttt gcttctcatt caattcttca 2139721 ttttgttctg tatctttttc gcttgtcatc atggcacctc cagttaaagt gtgcccaaaa 2139781 aatgaaatgt caataaaaaa gctcacactt tttggcagct gcgagtaaaa tttgaaaata 2139841 acgggtataa tgcatgtaga aaaagcaagg ctatggcaat tttttcagcc tgtcaatcta 2139901 gaggtttagc gctgtttcct gtacaataga gtgaaaggaa atggttagca atcctaaaga 2139961 aataggcagg ttgataatat gtcaaaacat aaagttccgc ccgcttacgg cgggcaggct 2140021 gttgtggaag gcgttatgtt tggcggaaag catcattacg ttacagccat cagaagaacg 2140081 gatggaagca ttgacttttt taagcttcca cgcaaacaca acccgaaact gaacatcgtg 2140141 aaaaagatac cgtttttacg ggggatcgcg gccattatcg aagcgagtgc aaacggcaca 2140201 aagcatttga atttttcaag cgaacgttac gggctcgatc catctgaaga cgagacactt 2140261 gagcaggaag aaaaaaaatc ctctgggctg tctatgtatc tcagcctcgc agttataggc 2140321 gtcctatcat ttttgttcag taaattcgta tttacattgg ttccagtttt cttagcggaa 2140381 ctgacaaggc cgattttttc cttgaacaca gcgcaaatcg cgattgaaag cctgtttaag 2140441 ttgattttgc tgctcggtta catctatttt ttgtccatga caccgcttat taaaagagtg 2140501 tttcaatatc atggagccga acataaagtc ataaactgtt atgaacagaa tttgccaatt 2140561 actgtggaga atgtccaaaa ccaatctcgg cttcattacc gctgcggatc aagctttatt 2140621 ttatttacga ttattgtcgg catgtttgtt tatttactcg ttccgacaga tccgctttgg 2140681 ctgcgtgtta tagatcgtgt cgcactgata ccggtcgtgc ttggtatatc ctttgaagtt 2140741 ctgcagctga caaacaaagt gcgtgacatt cccggtctga aattacttgg gtacccggga 2140801 ctttggcttc agctgttaac cacaaaggaa cctaaggatg aacaggttga agttgccatc 2140861 gaaagcttta acgaacttct cagactcgaa gcattgtctg agcaaaatca gaagccttct 2140921 cacaacgtca tctaaaatcc gttgccctgc tattactttc ggaggtggac agttatgaat 2140981 catcgtgtac aacctattat tgctgtatta attgcgctgg gagcgttcgg tttcctctat 2141041 gtgctggtaa ccaatcccgg agaaatggca aaaatggcgg taaccgtcat cgtggcaggt 2141101 atcattattt attttattgt gaaatatgta atgaatcgaa atgcgggcag cgaaggagca 2141161 gccttcaaaa aagcggcgaa acaatcacgg cgccggatga aagaacaaaa agcaaaacac 2141221 cgcgccggac ataagggacg tgtcagccac ctgcgaagcg ttccgagcgc cagcaagcct 2141281 aagccgatga ttctcaagaa aaaaagccag actcagctga ctgttataga agggaaaaaa 2141341 aataaaaaga aaaacagagc gcttttttaa taggtccact gctttaaaaa cagctctgtc 2141401 cgtcttttac ctagctcaat cagggctagt tttttttgtt gtgttaaatg aaaatcagtg 2141461 gccattacgt catcaacagg gagaaaaatg atattttgtt catagcgtga cgcaatgtgc 2141521 cttgcgtcat gagcatcctt catcgtttca aacagggcgc cgaacagttc aaaagcgttg 2141581 cggatatttt ttttcggacg ctctctttca cgcggcgcaa gcgtgacacc gatcacaggg 2141641 cgctttcttt cctttgaaaa cagccagatt ggaaaattgc ttaacacgcc tccgtcgaca 2141701 accgtggcgg tgcctgtgtc cgtttttaat tttatcggtt caaagaaata cggaatgctg 2141761 cagctcattc tgaccgctct ggcaaccggg aacatatctg gatttaaccc gtaacgggcc 2141821 aaatcgtccg gcaaaacaat catggtgccg tttgtcagat cagaagcaat aaggcgcaga 2141881 gaccctttct gcaaatcgcc gaaaaccctt atgcctttcg ctcttaacag atcagcaatc 2141941 catttttcta tcgtatcgcc tttgtataag ccaagacgcc agtagatgga cacccactgg 2142001 agcatcttta aggggagaaa tgagtacctc tgatccagca atttctctcc gtccacttct 2142061 tcaattaaag cgtggatttc cttactggtg taacctgacg caatgaaagc ggcaataatg 2142121 gcgccggcgc ttgtacccgc aactctttta aagcggaagc ctttttcctc aagcacttca 2142181 taagcgcctg cgagcgcaat gccttttact cctccgccgg aaaacacacc gtcaatatac 2142241 atctcattcc ctccccctcc atccgatcgt ttattaccat tttaagaaaa cacgcgaaga 2142301 aatagaccaa cgaatgacgg gtggcgtcag cgtatcaaaa aagacggcct ccttcgagac 2142361 cgccttttta ctgattatga tgttctgttt tcttttggat tgatttcaga tcttttttac 2142421 gggcatcatc ttcttcaaaa tattgaacaa gatccccgat gcgatcaata ctgttccagc 2142481 ttaaatgatg ttcgattcct tcgacatcgt tatatatttt ctcttcatca acaccaatga 2142541 ttcttaaaaa ctgctcaagc aattcatgtc tgtataccag ccgtttgcct atttttttcc 2142601 ctttagacgt taacacgaga ccgcgatatt tttcataaat taaatattcg tctttatcta 2142661 gtttttgaac catttttgtt acagaggagg gatggactgc caatgcttcc gcgatatcgg 2142721 aaactcgtgc atatcctttt tcttcaatca gcatataaat ctgttcaata taatcttcca 2142781 tacttggtgt tgtcatcgaa accctcccaa aaagcacctt aactttataa accattacaa 2142841 gtttacacta atgaacttga aaaaacaagg atgctccgcg ggtcaaaagc cctgtttacc 2142901 gcttataatt ccattcatct gaagcgtact ttgtttcagc caagtgatga acaaaatcaa 2142961 gctcttcctg agaaagttca tatggctcca aatgaatgtt aagacctgtt tcaaatcctt 2143021 ctttaaaggc tttacgagcc tcatccatcg tcacccgctt ttcgatgagt tcattaatgg 2143081 caaccgcttt atttttgaaa ttgcgctgca tccgctctct tactctttca cttggatata 2143141 agaacagatc gaacagcttg tcctcatcta aatcaagaag aatggagcca tgctgaagaa 2143201 tcacaccttt ttgtctcgtt tgcgcgcttc ccgccacctt gcgcccctca accactagtt 2143261 cataccacga aggcgcgtca aaacaaacag atgaccgcgg attttttaag ctttcttttt 2143321 ctttttcagt tctcgggatg gcaaagtaag cgtccagacc gagatttcta aagccttgaa 2143381 gtatgccttc tgaaataacc cggtaagcct cagtaacagt cgccggcatc tcggggtgct 2143441 cttccgaaac aattacgctg tatgtcagtt cctgatcgtg cagcacacct ctcccgccgg 2143501 tcgggcgtct gacgaatccg agattatatt tatgtactgc ttcaaaattg atttcctttt 2143561 taatattttg aaaataccct acagaaagtg tcgccggatt ccagccgtaa aaacggataa 2143621 ccggggggat tttcttttcg ctgtgccaat ataaaagcgc ttcatcaagc gccatattga 2143681 atgcaggact tgcattgcct gagtctataa accgccaagt ttctttttgc attttaagac 2143741 cttccttacc gttttaatag aatcagttta tcaaactgtc gggaaaatga aaaatatttt 2143801 agttccatta tagatgacaa tcacgctgtg ctttactata atagtatttg tcgaaaacgg 2143861 ctctatgacc ttgttttatg aagcagggtt ttgattttat atgctaaagg agtagaatca 2143921 cattgtctaa tatgatcgtt ttgattattt ttgctgcatt tatcatctat atgattgctt 2143981 catatgtcta tcagcagcga attatgaaaa cacttaccga agaagaattc cgcgcgggtt 2144041 accgcaaagc gcagcttatt gatgttcgtg agccaaatga gtttgagggc ggacatattt 2144101 taggcgcccg caacatcccg ctttcccagc tgaaacagag aaaaaatgag atccgtacgg 2144161 acaagcctgt ttacctgtac tgccaaaaca gtgtccgcag cggacgcgcg gcacaaaccc 2144221 tgcgcaaaaa cggctgcact gagatttaca acctaaaagg cggctttaaa aaatggggcg 2144281 gaaagattaa agcgaagaaa taaagcaaac agctgtctgg tagacagctg tttttattta 2144341 tctttcttcc gcctcgtatc tgagcactgg gtgtctcgcc gcttttgttt catccattct 2144401 ttttacaatc gttgtatgcg gggcctcctg aacaagctcc ggattctcct ccgcttcttt 2144461 tgcgatttga atcatagcat caataaacgc gtccagtgtt tcctttgatt cggtctctgt 2144521 cggctcgatc atgatgcatt cttcaacatt aagcgggaaa taaatcgtcg gcggatgata 2144581 gccgaaatca aggagccgtt ttgcaatatc aagcgtacgc actcccagct ttttctgccg 2144641 cttccctgat aatacaaatt catgcttgca atggcggtca aacggaagat cgtaataagg 2144701 cgcgagtttt ctcatcatat aattggcgtt taacactgcg ttctcagtaa cagcctttaa 2144761 tccgtcaggc cccatggagc gaatatacgt atacgctctc acattaatgc caaagttgcc 2144821 gtaatacggc ttcacacggc cgatcgcatg agggcggtca taatcaaacg taaagcgccc 2144881 ttcttttttg actaaaactg gctttggcaa ataaggaatc agatcttgtt ttacgccgac 2144941 agggcctgag ccggggcctc cgccgccatg agggcctgtg aatgttttat gcaggttgag 2145001 gtgcaccacg tcaaatccca tatcaccagg tctcgccttg cttaaaacgg catttaaatt 2145061 agcgccgtca taatacagtt tcccccccgc ttggtgtaca atttccgcca tctctgtaat 2145121 ctgctcctca aacaagccga gcgtgttcgg attcgtcagc ataagagctg cagtttcttc 2145181 attcactgct ctttttaaat cctctaaatc aacaagccct ttttcattcg atttcaccgt 2145241 aacggtttca aagcctgcta ctgttgctga tgcaggattc gtcccatgcg cggaatcagg 2145301 gacaatgacc ttcgtccgct tgaaatcccc gcgagcttca tgataggcac ggatcatcat 2145361 cagccccgtc cattcgccgt gcgctccggc agcaggctga agcgtaacct catccattcc 2145421 cgttatttct tcaaggtgtt tgcttaaatc atataaaagc tctaatgcgc cttgcaccgt 2145481 gtcttcatcc tgaagaggat gaatcgcagc aaaaccagga atacgtgcga ttttttcatt 2145541 gattttcgga ttatatttca tcgtgcaaga accgagagga taaaaaccgg aatccacccc 2145601 gtgattgcgt ttggacagcg ctgtataatg gcgcatgatg tccagctctg aaacctccgg 2145661 cagcgctgcg tcttcgtcac gaatataggt gtctgacaag aggtccccca attcgatttc 2145721 cggtacatcg agctccggca gactatagcc gattcggcct tctcttgaaa gttcaaaaat 2145781 aagtgcctgg tcctgattac tcatggcgat cccccaattc ctgaatgagt gcgtcaattt 2145841 cttcttttgt tctcagctct gttacagcaa tcagcatatg gcagtccagc tctggatacg 2145901 tcaacccaag atcatatccg ccaatcatgc cttttgccag caaacgcttg ttcacagctc 2145961 tcaccggctc atccagtttg atgacaaatt cattaaacat cggcccgtca aacataacag 2146021 taaggcctgc tttttttgct tcttgctttg catagttggc ttttaagaga ttttggcggg 2146081 ctatatcttt tacgccgttt tttccgagag cagtcatggc cactgatgct gccagcgcat 2146141 ttaaagcttg gttcgagcat atatttgatg ttgctttatc ccggcggata tgctgctccc 2146201 tggcttgcag ggtaagcaca aagcctcttt ttccgttttc gtcttccgtt tgtccgacga 2146261 gacggcccgg cacctttctc attaattttt tagtaacggc aaaaaagccg caatgcgggc 2146321 cgccgtatgc tgaaggaatg ccgaaaggct gcgcatcacc gacgacgata tcagactgaa 2146381 acttgcccgg cggagtgaga agacctagcg ccagcgggtt ggctgaaaca ataaacatgg 2146441 atttcccttg atgagcgata ggctcaatat cctttagcgg ctcgatcctg ccgaaaaaat 2146501 tcgggtactg aacgatcact gcggctgtgt tctcgcaaac ggtttggcgc aatgcatcaa 2146561 gatccgtaac gccatccgca gcgggtactt caacaacatc aatatactga ccttttgcgt 2146621 aagttttcag cacctctcgc gattcaggat gcacggtttt tgacacaaca atttttttct 2146681 ttttcgtgtg gcctgaagca agcattgctg cttctgccaa ggctgttccg ccgtcataca 2146741 tcgaggagtt ggcgatatcc atgcctgtca gttcacagat catcgtttgg aattcaaaaa 2146801 tagcctggag ctctccttgt gaaatctctg gctgataagg cgtatatgcg gtataaaact 2146861 cagagcgcga aatgacatga tccacaatga caggctgata gtggtcatat acacccgctc 2146921 ctaagaaaga agcgtattgt acggtatcac gatttttaga ggccagcttt gtcagttctc 2146981 ttgttaattc tgtctctgat ttcgcttttt tgatttgatg ctctttttta tatttgacgt 2147041 tttccggtat atcagcaaat aaatcatcga tgctgcttac gccgatagta gcaagcatct 2147101 cctgtttatc cttttctgtt gcgggcaaat aacggtgctt catgtgttgt ctcctctctc 2147161 caagaaaaaa tattagcgtt tataaaatgg tgttttgaca acctttgctt tcactaattt 2147221 tttgcgtatc tctacatcta caacagtccc gatctcactc gtttccgaat caattaaggc 2147281 aaggccgacg ttttttccta atgtcggtga ctgcgtgccg gttgtcacct ttccgacaga 2147341 cttgccattt tggaaaacct catatccgtg ccgcggtatc cctttttcaa tcatttcgag 2147401 accgacaagt ttgcgcttcg ctccgttttc tttttgttca ctcaatactg acttaccgaa 2147461 aaagtcagac tcctttttgt gctttacagc aaagcctata cctgcttcaa tcggtgtaat 2147521 atcccgggtc agctcctgac cgtagagcgg gagcttcgct tcaaaccgga gtgtatcacg 2147581 tgcaccgaga ccgcatggaa tcaatccgta tgcatcccct gcatcgatga tttttttcca 2147641 aatatgcata gcatcatcac tgcggcagta aatttcatac ccgtcttctc ccgtatagcc 2147701 agtgcgtgaa ataagtgctt tgcggccgct gatatcggct tcatcaataa acgcaaacgg 2147761 ctttaatgca gacacatccg catctgtcag attttttaag atcgcttctg ctttcggtcc 2147821 ctgtacagcc aagagcgcga tttgatctga ctgattgtca atctgcacat cacctgctgc 2147881 atgttctttc atccaagcca agtctttatc tatattagaa gcattaatga caagcagata 2147941 gcggttctct cctttttgat agataagcaa atcatcgacg gttccgccat ccgggtaaca 2148001 catcgctgta tattgagcac ggcctggcgt taacgcggaa acatcatttg tcatcaatct 2148061 ttgcaaaaaa gacagactgt cgttccctga cacttcgact tctcccatat gagatacatc 2148121 aaacaaaccg gctgcagttc ggacagcctc gtgttctttt tttatagaag aaaattgaac 2148181 aggaagctcc cagcctccga aatcaatcgt ttttcctcca tattccttat acaggtcaaa 2148241 taacggcgtt cttttcagca tctaattcct cccctttatc aacggcgcag ctaaaaaaca 2148301 tacaaaaaag gacagagaaa cacctcatgt aaaatgaagg ttctctgtcc tggcacctga 2148361 aagtttactt tgcatacgca aagacgtccc ctttggtggt ttgcgcatcc gcacaaacac 2148421 tctccagagt tgcgtcgagc aagagttctt ttgcctgaga gattcactcc gcagtttgct 2148481 ccttcggcgc ctgtatcccg aggttttcgg tcaggtctct ccccttgctg tcattcgctc 2148541 atattttcat gctgttatgg acatactata gcaatatctt acatcaaata catactcata 2148601 tcctaccatc atcactatat gctgggcaac agcaatttgg gcagattttt cttatattat 2148661 tcatcttaag aatcgaagaa taagaaaggc ggtttcaaag caatgaatac agaaatgatc 2148721 tacgatgcaa aatggcctga agaatttgct gaaagactga aaaacgatgg cccttgggca 2148781 aactgggaac tgtacaagct ctctgcagaa atccagaaaa cattagcaat tccagagttt 2148841 gaaggcttac gggctccttt atatctgcct tcctttacgc cgctccccca ccagcttgaa 2148901 gtggcgcaaa aagtggttga aaaaatgaac gggaaagcga ttttagcaga tgaggttggt 2148961 ctcggaaaaa cggttgaagc tggactgatt ctaaaagaat atatgattcg cgggttagca 2149021 aaaaaaattt tgatccttgt gcccgcttcc cttgtgtcac agtgggtcaa agagcttcag 2149081 gaaaaatttt tgattccggc tgttgaacaa aagaaaagct atgtgtggga gcaatgcgat 2149141 attgtcgtct catcaataga caccgcgaag cgctcgcccc atcgagaaat cgttctgtct 2149201 atcccatatg atcttgtcat tattgatgag gcacacaaac tgaaaaatag caaaacgaag 2149261 aactatgaat ttgtccggaa tctcgtaaaa aaatattgcc tgcttcttac cgcgacgcca 2149321 atccagaacc gtatcgaaga gattttcaat ttggtgtcct tattaaaacc cggccattta 2149381 ggcagtcaga atcactttca ggaggagttc gccaagaaga aatccagttt agaagcgcat 2149441 gaacatttaa aagatcttgt gaataaagtc atgatccgta acaggcggca tgatacaggg 2149501 ctgaattgga aacagcgcca tgttgaaaca gtgccgattc aattttctcc atcagagcag 2149561 gcgctttatg atgaaatttc tcgtttgaag gacagtatca ataaaccagc cagcatgttc 2149621 tcgattatga ccttgcaaag agaatgctgt tcgagcagag aagcggtata tatgacgctg 2149681 aaaaagatgc ttgatcaaaa agagaaacaa gcacctgcca ttgatgagga tacgatttca 2149741 gttttgatag atcgcatcaa tcaagtgaca caaaactcta aagcgcttca agttgttgac 2149801 ttgatcaaaa agatcgacga taaggtcatc atttttacag aataccgcgc aacccagatt 2149861 tatctgcagt ggtttcttca gcaaaacggc atcagttctg tgccgtttag aggcggattt 2149921 aaacgtggaa aaaaagactg gatgaaggat cttttccgcg gaaaaatcca agtccttatt 2149981 gcaactgaag caggcggtga gggaattaac ctgcaatttt gcaatcacat gatcaactat 2150041 gacctgccat ggaacccgat gcggcttgag caaagaatcg gaagaattca cagactcggg 2150101 caggagcgtg acgtgcatat ttataacatg gcgacaaaac atacggtgga agagcatatt 2150161 ctaaagcttt tatatgaaaa aattcatttg tttgaaaaag tggtcggtga acttgatgat 2150221 attttaacga aaattcaagt gaacaatttt gaagagcacc ttcatgacat tttgtatcac 2150281 tcagcaacag aagaagaaat gaaaataaaa atggataact taacctcatt tttgtcttat 2150341 aaaaaacagc tgcctgctga aaaaagagga tcttagcctg taaggaggtt ttattagtga 2150401 gacagcaaga ggttcacgat tttctgctgc gtttttttca agcaaacagc tgccaaatcg 2150461 tcgatcaagg cttaggctat atgacagtgc agcttacagt tgaaatggac aaacaaatca 2150521 tgaaccgccc tttctactgg cattggcgcg agaagacagg cggtgatccg aatccaatga 2150581 aaatcacttt tattacagat aaagaaaatg cgccaaaaga cctagatggt gaatttatat 2150641 attttggggc cccgcgtctt tttcaaatat tcaaagctgt taaacaaaat gggagattta 2150701 ccagaatgta tgagaaaatt gaatcagccg gagctaaagt cccacttcag ccttggcttg 2150761 gtataaatgt cacgatttca taccagtccg acatgaaaaa ggataagtta ttgtcactag 2150821 gtcttcacct agtctctgga acgataattg aagattttca aagcaagctg acccagtttt 2150881 cactgacgtc tcaaatatgt gactattgct tcaccatttc acctatgatc aaaccagaaa 2150941 gcggacttaa gcgtatggaa aactatattt ccaaatccgc tatgcaggag ccgtccgact 2151001 gggcggaaca ggcggttaac aggtggaaga atgatatgac attgcttgat aagttttacg 2151061 agcatataga agaaaaacca gaagaatacc atctagaaaa acaggcgctg aaaaccttgt 2151121 atcaaccaaa gatatcagtt gaaattgaaa atggcggatt gttttatctg caaaataata 2151181 tttcaagcta acttttttac cattcgacat cattctcgtt ttttttgaga aaatacgatt 2151241 ataataaagg tatattggaa aaaaattctg gtgatttaat ggcaaatgac ttccagagac 2151301 taatgaagca tacaataagt catggccgga ctggctgaaa tacataaaca agtattttag 2151361 gaggagaaac tgcatgaaga atgcaaaaca agagcacttt gaattggatc aagaatgggt 2151421 tgaattaatg gtggaagcca aagaggcaaa tatcagcccg gaagaaatac gaaaatattt 2151481 acttttaaac aaaaagtctg ctcatcctgg tccggcagcc agaagtcata ccgtaaatcc 2151541 tttctgaatg tgctataata tcacaaggaa ggtgatgaca ttgattggcc agcgtattaa 2151601 acaataccgt aaagaaaaag gctactcact atcagaacta gctgaaaaag ctggggtagc 2151661 gaagtcttat ttaagctcaa tagaacgaaa tctacaaacg aacccctcca ttcaatttct 2151721 cgaaaaagtc tccgctgttc tggacgtctc ggttcatact ttgctcgatg agaaacatga 2151781 aaccgaatac gatggtcaat tagatagtga atgggagaaa ttggttcgcg atgcgatgac 2151841 atccggggta tcgaaaaaac aatttcgtga atttttagat tatcaaaaat ggagaaaatc 2151901 ccaaaaagag gagtagtgcc tgagcagagg cactaactcc tcttttgtca ataaccatcg 2151961 agacggccca gtatatgaat actgggccgt ctcttttttt tgctgttatt aatttttatc 2152021 ctcgctatgc gctttttcat tttctttcac gtaaccatct ttatcagtat ggtccttttt 2152081 gattgtcaag ccgttccact gtgtagcttc gaatgagaat tgaagcttaa tggagttgcc 2152141 ttgatattta ttttgaacca taagcccttt ttcatctttt gttttatcat ccttgaattg 2152201 gatttccatt tgaacctgat cgaagtcagt tggtgttttt ggaacaccat catattcagg 2152261 agcggtttta ccatcaattg ttgctacatt gactttaccg cttgcattta agaatttagg 2152321 gtcaatttgt tttttgattt tttcagcagc cgctgcatca tttttagcag acatcaaata 2152381 caagtcttta aggttcgcat catctaaaat aatgtttttc gggtagccat tgccgccctc 2152441 ttttccaact gtcaacaatg tcacttcaaa ctggctgagg aaatcttctg gagatgtatt 2152501 gctgccgccg tttgctttaa aatctccata attaagcgcc attagaactt ctttgatcgc 2152561 aagtgatccg ttattttcaa attggaaatc ctttgtcaac ttatctcccg gctttagatt 2152621 tgataagttc acactcgctg aattctcttt agcagataaa tcaagcgtac ctgatgcaaa 2152681 agtagcatcc tttgatttaa tgtcgttaaa tgctgcccat gttcctcctc caactaaagc 2152741 taatcctagt gctgcagaag caactcctaa actcaatttc tttttcatac ccatggtaag 2152801 ctcccctttt attgaatgat tttatatcga aacctgttgc caggtttaca actgaagtta 2152861 agtagacatg gtgctgtcct ttgtatctgt ttccaaggct tttgtctttc tttcaatttc 2152921 tctaatggcg ctgctgatcg tcacaaaagc gtaaactaac agcatcacgc cgggaacaat 2152981 caataataca gccgttccaa tcggctggct ggcaaaatga agcatatagc cggcatatgg 2153041 aagctgaaaa cctgtgtatt gcgcgcgaac attttcgtcc gatacaggcg ctgaatcagc 2153101 tgctgcatta ttatcacctt ttgttttaaa taacaaatgg tctccttgct ttgttatgtc 2153161 aacaattctg tgggtgaccg ccgtatttgc atcctgcata aatgtaataa cgtcaccttt 2153221 ttggagctct ttcacatcag tgatttcttt gaccaatatt aaggaacctg tattgaactc 2153281 cggctccatc gaacctgaca gaactgattt cagcgtatac ccaaacactg ccggctctcc 2153341 cccggatgaa cgtgttgaaa tcacgacaag tgtcagcaca ataataagag taaagatgat 2153401 cacgtataaa atattactga tcagcttcat tgcttttttc atcctcttcc ccgctttcct 2153461 tctggtctga ttgagtttct ttttctttgg ttacagcttc ttgagatgtt tcttctttca 2153521 ttgttttttc cggtatatct ttttgtgttg tttcattctc ctttttgacg tccgactttg 2153581 tttctttttt agggactgtc ggtttttcat cgcattttgc aagcctcata ggctccgacc 2153641 actcaaatgt actgccgttt gccgggtagc ctgccggttt atatacttta aatgcataaa 2153701 tgccgggttt catttttttc ttggtctcaa ttttataaag tgaatcgccg atttgattgg 2153761 agacaaatcc tttttcgatc acgttcccat cctttaacgg tttgcgggca ttttcaagct 2153821 tatgaagctc ccacttccac tttgatttct taagtttctc acctgtattt tcgagcacag 2153881 caaataaggc gaaaggtgag catacagtgc ctttcgtatc cgtttgatct gatatgtgca 2153941 aatcactttg atcccagcgt ttatcataat ggcagttttt atctgtatgc tgaaagtctt 2154001 tacacgtttg aagtgagaca tcaaatgttt caatatcatg aaaagcagcg cttgtatcat 2154061 cggaaaattg taagcatatt gcggcagtca gactgaaaat gactgaaagc tgaaagataa 2154121 gcagaacttt cagtttcgtc ttcgcctttt gctgattgtg aaacaatcga aacatatctt 2154181 acctcctgta aaacactgta acttgatatg acaatcgttc tctttaaaga acttcacaaa 2154241 tagagtataa tcaacgattt atagatttaa aaacaccgaa atcgctcatt ttgttcgttt 2154301 aaaagaatgt tttcatcata ttacaaagtc ttgctcagta ttgctcattt tttcaatttt 2154361 ttagaaattt ttgggattgt tatgtgagaa tttaaatgca tatcccatta ttatttggta 2154421 ataataaaca aagaaagggt gacagcatga tgatcaaaca atgtgtgatt tgtctatctc 2154481 ttctcgtctt tggcaccaca gccgctcacg cagaagaaac accgcttgta accgcccgcc 2154541 acatgtccaa atgggaagag attgctgtaa aagaagcaaa aaaaaggtac ccgctcgcac 2154601 aggtactgtt caaacaaaaa gtatgggacc gtaaaagaaa agatgaagca gtgaagcaat 2154661 accatttaac tctgagggaa gggtcaaaag aattcggcgt ttttgtgacg atttcatttg 2154721 atccttatag ccaaaaggtc aataaaattg ccatattaga agaatatcaa taaggtcctc 2154781 cattttttga aggaccttat tcgtttattt gcggttattt tttccgtttc agccaaagtc 2154841 ggaagccata gggtaaaata ccgaaccact gctgggaaac aggcgttttt gtttctttcc 2154901 gcacctcttt tcgttctttt cgctcatctc tcggagtatc tatatatttg acaaattgct 2154961 gcgtcatata tttaacataa tcattcgttt tcacgtgatc acctcatcat tcaattatta 2155021 tgagtgttgt ctcacatgac tttttttata ccctttacac tgttttattc tgtccatctc 2155081 agcagttttt tctgtttttg gtcaaacacg atctgtgcag ttctttctgt tcccgaatcc 2155141 gttgacactc ttaagttgat ttctttttgt tcttttatcg atgtatcatg aatgtaataa 2155201 gaaacccgtc catatagaaa ttgctgcgta ccctcctggc ctttccgttc ctctagaaca 2155261 tgccgaatcg aaagaagcac cccattttga agcaaattct ctcctatgta taactctttt 2155321 gtttccttct caaacatgca gcgtgaaata tattgagcag caacaaagtt cacgattaac 2155381 agcacaagcg ctgacacaaa aagaacagct ggataaataa accctcttgt acgatacatt 2155441 cacccccctc ctaaatacga atagactgga aaagcagttt gatacacttt ttggtcttca 2155501 ctctcaattt tcagcaaaac aacaccattt tcaatatcag ctttcatggc agtaatatga 2155561 tctaaaatcg gaacatgccc tttgccatcc actctttttc ttatcattga atgataaatg 2155621 tcaaaacgga tgtcttgtcc ggaaagattg gtgcagatta acacgctccc atgctcggct 2155681 gtcttaactg cctgtgattc cttgcattca ttcatcatct gttctatcga aatcatccat 2155741 tcctgctgtg tgaaaccgtc atgttcctgc tgtcgagaca aaaacagatg gataatcgca 2155801 gctaacgatc ctgatatgag caaaaagact gagagcgaaa ataatacgtt aagaagcgtg 2155861 tagccattct gtctgcaaaa tgctgaggca aaatgatttt tctttataag ctgcggcttt 2155921 gatacatacg ttttgatatt cgccctcctc ctcccacttc attgcataga tatgattgtt 2155981 ctttgtaatc gtttttgacg cggctccttc accactcatg acatatttgc taatgctctc 2156041 attcatcatc tgatagccaa tttctcgtga ttccgccatt ttttcatcag ccatcagctt 2156101 gtcccacaag gggacgactg tcagcagcac aaacagccac aggcttagcg cagacattgt 2156161 ttctattgta gaaaaacctt tattttctct ccacattgac tctcccgctc cctagataaa 2156221 ctgttatgtc ataaacggca tggcctttta ctcgtatttt tccgcctgca ttcgggtgcc 2156281 ctttctcatt aaattccaaa cggtctttta atgtcagcag ttctatagaa agtcccgttg 2156341 catacggacg ttcaataacc gtatcaccaa tgactaattg atattctttt ttatgaaaga 2156401 gaatttttgt tctttgttga cgggaaatag cagtctgctg tgtgagcata atatcatttt 2156461 tcagctgact tgctgcctgt cggacagctg tattgtcata agcaggagga agtgtagtga 2156521 agacggccac caggaggata gaggcaaggc ttaacacaag caaactttct aaaagggtaa 2156581 accccttctc ctcgtttaat ttaatgttca accttaactt ctccgccggt gatgataatg 2156641 cgcttaccat ttggacagac agcatccttt ttcacatagc cctctgactg taaatcggca 2156701 aggctcggag tttgtccttc atgatcaagc tcaaatgcag tcatttgtgc cttaaccatg 2156761 ttttgtaagc cttcacagcc ctttttttga atggtttgat tatgtttcgt gacgttcggt 2156821 atcgtaatta aaagcaaaat cgaaataata aagagcacga ttaacatttc aacaagtgta 2156881 aatcctttct cattcatcag cctcttcctt tcacatttga ttcatcatct gatacatagg 2156941 cacaagcata gataaataca caagtaagat catcgctgca acaaatccat aaatcattgg 2157001 ctgaaggatg cctgtccatt tttgcgcttt gtgttccagc cgctgtaata tgaattggct 2157061 gtatgtgaaa agctcccgat ccaatcggcc gctcagctgg ccgtgagata tgacttttga 2157121 taaatcagtt tcataaaaaa ggcttccaca aatagcggat tcaattgact caccggcttt 2157181 tagccgttca atcaattgtt cagcctcgca gcggtagaaa gggagaaacg tttgatgttt 2157241 aaatgcatta aggctgtcat aaattgagag gcctgatttt aaaaggctgc ttagctgcaa 2157301 agaaaaaaag tagctgttaa acagctttac aagctttcca accaaaggaa tcctgataca 2157361 aatcagcatt tgccgggcag gtgatttttt cttaaacaca agccaataat aaatcccgat 2157421 acctgctgta aaaagaacaa gcaaaatgat cacaagatca atatgctgaa aaaaagcaaa 2157481 aagcatatcg gttgaacgtg aggtttccat attcatcgat tgatagatac cggaaaactg 2157541 aggaatgatg atggactgta acatataaaa catgacagcg accgtaaaga tgaggaaaag 2157601 cggatagcgc agcactcttt tcagctggtc tgcctgtgca atttttcgtt ccagcagctc 2157661 tccgctctgg atcattgaag caggcagttc accatgtgtt tcagcaaaat aacaaatacc 2157721 tacggcttcc ttatgaaatg acaaactctt tagtacttga taaaacggag ccccttccct 2157781 caaacaagtg accgaatcag tcaagtcagc cgcctgcctc ttattcatct gaagttccat 2157841 caggcgtaat ccatccagaa gtgtatatcc gcccgcagtc atttcaccga gcctctttaa 2157901 taacctggct tgatccttta acaaccagac ttttctaatc tttttcatga taaacccacc 2157961 ggtcatagtt gtttgtcgtt aaatagccga gcgcaattcc ttttctgata atttgacgaa 2158021 gcgtttgata ttggtaattt gcatgatttc cttttgcctc ctggatacat tgctgaagat 2158081 ttttcccgta tagaagctca taaacgctag ctctcctagt atttcgtgac tgtcggcaat 2158141 acactgatga acatccgttt tcacaaaacg ggcaagccaa atcaaccaag cgctgagccg 2158201 ctattgcaat gacagtctgt tcgatttcat tcatattgat accgaattca agcagtctgt 2158261 aaattgcgcc ctttgcgtct ctcgtatgaa ggctcgttag taccagatgt cccgtcatcg 2158321 ctgcccgcac cgcaatttca gctgtttccg cgtctctgat ctcacctaaa ataatcatat 2158381 cggggtcatg gcgcaaaatt gctttcagac ctgcggaata agttacaccg gctttttcat 2158441 tcacctgaac ctgaagaaca tcttcgtccc ttgtttcaac agggtcctct aatgtgacaa 2158501 tatttcgatt aaagtgtttt tttgcatatt gaacgagaga gtataatgtg gtagtcttcc 2158561 ctgaaccagt cggcccggta aaaatgagca tgccatggga atgttttaaa aacgagagta 2158621 atgtggctcc tgtcttcgga aatagcgaca atttatcaat cgaagggata ttgtattggg 2158681 gcatcactct gatcacgagg ctttcttcat taattgtggg cagcgttgac attcttaaat 2158741 gaacatttcc ctctttcaac tttaacgtaa gcgaaccgtt ttgcggcttt cgcctttcac 2158801 ctatatccat tgctgaaaga aatttaaaat gtgaaatcag tcttacgcac tcttcttttt 2158861 tcatgtccct ttttttcagc aaggcatgat cgacccgaaa atgaatgata gcgtcccgct 2158921 ccctcggcac aatgtgaata tcagaagcct ttgttagata tgcctcttca atcaagtttt 2158981 tgcttacctt ttctattgaa tccaatttga ttccctctcc tttcaacgca tattgtagaa 2159041 aaagaagaaa aggtaatcaa acagggaaaa cgtgattttg tgagatgtta tatgctgaaa 2159101 aaccaattct ttctggcaag aaaaaagact ttcaactgaa tgtacccctg tcattataat 2159161 tttccctata aataaaaaag cagacatggt caccatgcct gctagattcc attttcatta 2159221 tgctgttttc gcttattgac cagtatcttt ctcaacggaa agatcgccta atgcaacaat 2159281 accggtcatt tggtcatttt caagaatcga taaactgcgg atttaatgct ctgtcataag 2159341 ccccttgaca tcgtatccgg tcaccctgat atgtctggtg aaaaagcggg gcacgctgca 2159401 caaaatatga aacatcctat agagtccgcc tttttcgagg tttctttttc ttcttccgct 2159461 cctgcagcat atctcccgtc cagccttttt ttctcaaata gagatagatc agaactgtag 2159521 atgtgacaat caataagagg gaaaagagat atccgtattt ccaattcagt tccggcatca 2159581 ctgaaaagtt catcccccat aaggcaccca gagctgtaat cggagtaaaa agcgtcgtga 2159641 aaatggtcag cgcttttaca atttcattcc ccctatgtga ggtaatgact tcctctgaat 2159701 gcagcagatt gttaagctcc ccttcaaatt cgctgatgta tgtaaatccc ctgtcaatct 2159761 tcagttgtgt ccgctgataa tcctttttcc cttcattttg aggtaaaaag gtttctttca 2159821 acgccatttc aattttttta gcgcttaata tcaaattttt ccaaatcatc agttcatggc 2159881 gcaggagatg gacgcggttt aaaatgcttt tgctattgtc gtctttaatt tgccatctga 2159941 gctttctcag cttgacttca aattcatcaa caccgattaa atacgcattc attagttcgc 2160001 cgagaagaat taaaaacccc tctatcgcat tgtccgctct ttccatttgc cgaacaactt 2160061 ctttgccttt aatctctctc aaaattgaaa agtcaaagtt gattgtaaaa aaatattgtc 2160121 tggtgatata aaagtgaaaa acagtatggt ctttttcttc accaagcccc tgatcataaa 2160181 caatcgaccc aaatactgct tcattttccg tttcagttgt atctactcgc aaaaaattaa 2160241 cgtgatggtt attttcaaac cacttttcac actgaggcca gtgagaaaaa tggattagat 2160301 ctcttgcctt acttctttct tgaggcccca tttggtacca aaaccaatcc tttcccgtat 2160361 gtgccttcat gtcaagctcc tccaaacttt tgttctttat tctttaattg cccaataacc 2160421 gcgtcactaa accagtctgc cgcttcaaca catgttttat gagcattttc aggtggtatg 2160481 gaatgtagaa agacatcgga aaagggaggt gcatgccttc cttggagaag gcagttgttt 2160541 tggaatttat caatttacta gcagtcgcta ttctcatttt gttaacagga tttttcgttg 2160601 ccgtagaatt ttcaatcgta aaagtgcggc gatccaaaat tgatcagctt gtcgcaaaag 2160661 gaaagaaagg tgctaaagcg gcaaagcatg tcatcactca ccttgatgaa tatttatcag 2160721 cctgtcagct gggcatcaca gtcgcagctt taggactggg atggcttggg gaaccgactg 2160781 tgcaaactct gcttcgaccg ctttttcata aagcaggctt aaatgaatcg cttacccacc 2160841 tgctttcact cgtcatcgca tttttagtgg ttacgtattt aaatgtcgtt attggggagc 2160901 tggcgccaaa gagtttcgcc attcaaaaag cagaaagcat taccttgttg ttcgctaaac 2160961 cgcttatttg gttttataag atcatgtttc cattcatttg gctgttgaac cactctgccc 2161021 gattgattac aggagtgttt gggctgaagc cggcatcaga gcatgagctg gcttatacag 2161081 aggaagaact tcgggtccta ttggctgaaa gctataaaag cggcgagatc agaaaaagtg 2161141 aattaaagta catgaataat atcttcacct ttgataaacg aatggcaaag gaaattatgg 2161201 tgccgcgaaa tgaaatggtt agtttgtcac tagatgaaga ctccatttca aatcttcagg 2161261 aaacagtcaa gcaaacaaaa tatacacggt acccggttgt aagagaggat aaagataacg 2161321 tcattggcgt gattaatatg aaagaagtgc tgttttccat gctgacgaaa gatttttcaa 2161381 tcaagaagca tcaaattgaa cctttcgtac agcccgttat ccatgtaatt gagacgattc 2161441 ctatttataa actattgctg aaaatgcaaa aggaacgcac tcatatggcg atcctcatag 2161501 atgaatatgg cgggacgtcc ggtttggtca ctgtcgagga tattatcgaa gaaattgtag 2161561 gagaaatccg tgatgaattt gatgcggatg aagtgcctca tatccgcgaa cttggaaagg 2161621 atcattactt gttaaatgca aaattattaa tcagcgatgt taacagcctg cttggaaccg 2161681 atttatcaga ggctgaagta gacaccttgg gcggctggtt tttgacacaa aacatagacg 2161741 ctgagcctga aagtgccata gaatatgatg gctactcttt taaggtaaaa gacatcaaca 2161801 gccatcacat tttatttata gaagttaaaa aagctgaata gcccgtgaaa ggctgttcag 2161861 ctgctatctt tcaagataaa catggcaaag gcatcaacac tcttttattt taaacccttt 2161921 attggccagg gctttagcaa gactttgctc tgttttcaca ttcgaaaaat ccagacccag 2161981 cttcacgaca gtttgggcaa tttccggcct gattcctgaa ataatagtct caatgccgag 2162041 caatttggtg ctgtcaatca ctttaaaaat ttgataggct accatggtat caacgatagg 2162101 aacgcccgaa atatctaaaa ataaatacga gagctttaac gctgagcact gctccagcac 2162161 agactccaaa atcgtcctcg ctctgtgcgt atcaatttca ccgacaagcg gaagaatccc 2162221 aattccatca gtaatcggca taatcggcgc actcaattca ttaatcattt ctttttgcgc 2162281 gtttaattgt atcatggtca cctggtgata ttcttccgta aacacttcga tgatctcatc 2162341 aatgttttga ttcaagatcc ggctccactc ataaaattcc tgaatgctga tgtcttgaga 2162401 agaagcttcg ctgaatttat gaatccattc aaacatgatg tgcctgaaag tgttaaactg 2162461 gccgacactt tgtgtaaccg tcacttcatg aacggcacgg tctctggcgc attgaagaga 2162521 ccaccggttg agctcatcct ctacgtcttc ttttctaagg gattttgcta cgatggtcac 2162581 caataattca tgctggtctt ttaacttttg ttctagtttt tgctgatctt tcgctgaata 2162641 cagccagctg ccgtttgacg tacaaacttc cagccattgt tgcgtaatat cttttttgtg 2162701 ctctgttaag tgctgatcaa gagctatcat cttaatgagt tacctcctgt ttttgaaaaa 2162761 tgtacgctat atatgtataa cgcgtctgcc tttacacata ctatgtttag attcaatggg 2162821 ctatagccaa gcggtaaggc aatggacttt gactccgtga tcgttggttc gaatccagct 2162881 agcccagttt ctgaacaggt gaaaaaccga agataagctg attcgtataa atcagcggat 2162941 cttcggtttt tcatcatgca gattgatgaa ccgttttctt cttcgataac ttcaacagtt 2163001 ctcccgggtt ataaccaatc accagctttt tgttgtctac tagaatcggg cgtcgcaaaa 2163061 gcttcggctt ctcgattaaa agttccagca cctcatttac cgtcatttct tcaatgttta 2163121 aatttaaatt tttgaaagtc tggcttcttg tcgccaaaat ttcatcaatt ccttctgtcg 2163181 ttaacgataa aatgtacttt aattcttctc ttgtcggggt ttctctgaat aagtgccgtt 2163241 cgttaaattc aatttgatgt gctttaagcc aatgttttgt ttttcggcat gacgtgcagc 2163301 ttggatatga gtaaaaagtt aattgttgtt ccattcgttt tttcctcctc agttaaccat 2163361 ctctttgtag aataactacc cggatcattt ttcatttaaa ccatttacag aacttttttc 2163421 ggattatttt ttaaaaaaca ttcatacaat agaaaacaca atcaaaggga caaattccat 2163481 ttgtatatta ataatgaaaa tgtttacatt tctaggtgtg atctattata ataacagtca 2163541 gagggactct cgggagggga taaaaatgaa tcgcatgttc cgggtgttag gattttggac 2163601 gggaattttt gcagtcatgt tttatttagg tgatatgaaa gatgcttccc ttttattttt 2163661 tggacagacg atcttatttg tgtttctatc gtatttgaac ttaaccgaac gcatgtatat 2163721 ttatattttt ggcgcttatt taacaatttt cttcgccggc tttacatatt actcaatttt 2163781 tattatggtg cccggcggcg gaggccatta aatgcagaaa gagacaaacc ttatcggttt 2163841 gtctcttttt ttacaatgaa aacccattta aaaacggatt ttgatcctgc tcagtcagta 2163901 cgtctgtttc aggtccatgg ccgcttaaca ccagcgtgtg ttccggaagc gtaagcagtt 2163961 tttcatgaat ggacgtcagc agcgtctctt gattgccgcc tattaaatcc gtacgtccta 2164021 taccgccttg gaacaagaca tctccggaaa tgaccaagtc tgcatctttc acgtagtaag 2164081 acacactgcc tggtgaatgt cccggcgtaa ataatgtttc caaatgaaac ggcccgatat 2164141 tcaactcacc gtcgccttca attagatgat ctgcaggctt agctgtgact tctatccctc 2164201 gcagcatgcc ggagccgttt aaagaagcgt ccgcaagcca atttttttca ttttgatgca 2164261 ggtaaacagg gatatcccat ttttctctca cttcatcaag cgccccaata tggtcaaaat 2164321 gggcatgtgt aagcaaaatg gctaaaggcg tcagcccttt ttcttttatg tattgattga 2164381 ttttatgtcc ctcgccgccc ggatcaaaaa tcagacattg atcatcactg atgagaaaat 2164441 atgcgttcgc ttgaatcggc cctactggca ttcgtctcca tttcactatt atcacctctt 2164501 tcttttttat gctcttatta tgagggtttt tgaaaaaaga ttcaaacaat cgcaatgaaa 2164561 acgctatcga caaacctata aaaaacaggt agaataaaac tggaaagaat tgcaggtttt 2164621 tcaatgtaaa gggggctgtg ttatgttact tgtcgtgatt ttcggccttg tcgctctttt 2164681 cgctttatgg ggagtcttgc gttctgttag aaataaaaat atactcgggt ttttattagc 2164741 cggtgccacc ttatttgtct ttggatggtt taccgtgatg accgtaataa acagcgggta 2164801 tccaaccgca cattaaaacc tgtatccgat cggatacagg tttattttta tggctgtaaa 2164861 tgtttattga cactttctat tttgctctca agcgtcgttt ttttgtcacg cctgtcatcg 2164921 atacggatat tcgttgccac tctgtgcaat cctttttgaa atggcgcttc gtgaattgcc 2164981 tgaataactg caaaaaggtc actgagttct ccctcgatca gcgtattcat cggtgtcagc 2165041 tgatatttga ttttcccttc tgcttgatat ccttctaata tcttttgcac atcggctacg 2165101 taagcactga cactgggtgt ttccgtaccg attgggataa tggttacatc tgcgatagcc 2165161 atcgttattc catctccttt tgatcaatga tgagttgctt cgtttcatgt gatttcaata 2165221 aaataatttg ctcaaaatga aagccgtata acgcatattt cccgttcgga gatatttgaa 2165281 tcggctccat ttcccgcaga gacacaagat cttttgtctc tcccgatgct acattgattg 2165341 ctgcgagctt atatgcatcg ccgctttgtt tgaatgtata aaacaggcct cctgcttcat 2165401 catagtcata ctccattgga gccaaacttg tatatttcgc ttggagcggc catttcgctg 2165461 taacaggtga tgttgattgc ggcgttttaa actgatacgt cccttttcct ccggaagctg 2165521 atttgacagt aaaactcatt tgatggaaag aatcgaagaa tagaacgtta tcctcaagct 2165581 tctgttccgt cttagaagct gtatcgaacg tatataaagg ccctgtttta tcgtctctac 2165641 cctcttttac ataatcaaat gtatttttgg atgtccaatg aatgaacgga acctgtactg 2165701 ggcttaagaa agattcgtct tttttagcat tcacctgata tgtatggaaa tcccagtttt 2165761 cattgaattc cgtcaccatc atttgataag gatcatactg attccaagca gcttcaagct 2165821 catacgtttc gtaatctttt tcgtaaagcg tctctccttc tgcattaagc aaaaccactg 2165881 ccgtcttttg gctatgtgtg atttgcagca gaatcatctg ctccctcgca ttgatttgaa 2165941 catcaacgat ttgaccatcc gtttgataga gctttttcgc tttgcctgta aagatgcggt 2166001 acgcaaaaag ctctgttttc gtcggattag acgcagtata taatattgtg ctgttattca 2166061 gccagccttc cgccccatcc gctttttccg cggaaagcgg tatgatgtct tttttctcat 2166121 cttttgccgc cgatgcctgt ttttgctgct gatgagatgg ttcgcatgcc gataaactaa 2166181 acagcaatac cgccagcaga ataaaacaaa ctgatctcat cagcattccc ctccgatcat 2166241 ctttattctc tcatatttgc ttcggcagaa aaaagaaaaa gtttcagtta ctcatgaaaa 2166301 aataacgccc tccacaagat accgcttgtg gcgttatata tgtgtgaaaa ctgctgaaac 2166361 ggcaaaggat tttggccttt tccaagttcc accgtatacc cttccttaaa ataatggtga 2166421 ataaaccaat cacgaaatcc agcatagctg tctatatccc ttactccctt ataaatgttc 2166481 ccgcttaact cctcaaactc ctttatgacg gcagcagatt cctcaggctc aaggccttta 2166541 tagccccaat aaatttcttc tccttgagta tgaagagcca gcagtctgtc aggcggattc 2166601 tccgtgatca gccggtacat cgcaatagat tccggctccg taagcggaga gattcccgga 2166661 aaatcgcggt agctgggtgc tgtcggtttt cggtattttt caatttccca taatgatgga 2166721 aattgtttat ttaaatcaac cccgtttata ttcgccttcc attcattaaa atttggacga 2166781 tgttcattta gcctttcgag ttcatctctt ctggctccca tgacttctga tccgtttaaa 2166841 acaagatcaa cgccatccgg attgacaaga ggaacgaggg ataaggatgt gctgttaaac 2166901 agctttatgg gagaaaagcc aaagaaaggc gaattgcagc ataatgacat acagtattcc 2166961 ttaaaccatt ttagcaggac agacgttgta atccactcat tcgcatgaaa tgacgcgttc 2167021 atatggacct tttttacggc atgctcccca ccagccttca gctcccagat aggcctgccg 2167081 agtacagaac ggccaatttc ccggcatgag acaaacggaa aaacatcaat aatcttcttt 2167141 atttcctttt caacagctga atcatcatag attttctctt gctcaatcca gctatctgaa 2167201 agtttcagct gccgaggctg taaaaagcgc tttatgtcct gaatggtttg aagctctttg 2167261 ccgctatgct cctctatcac ataaccaggg caatacaatt gatgtttttg tgcggagcga 2167321 tttgcacttt taagcaattc ctcgtctatc ttcagttctt tcgccacatt ggccaaattg 2167381 ttcttgatct caggtttcac cgtaataaac gccatcatca tccccctttt ttgttactat 2167441 atgacagcgt atttaaaaaa agaaagcctc ccgctcactt cgatgcggga gacattgtga 2167501 ttatgatgcc tgatcaagca tttgtttttc tttccgcttt gacgaattgt ccagcctttt 2167561 ctggtcataa aatcgcaaca aatccccata aatgatttca tcagaaagtg atagctcctg 2167621 ttttgcttta tcagcaaatg cttcacattg ttttgtctct tctaacggtt ttcccgtctc 2167681 tttgtcataa cacgcaccgt ctgtataaac aacctgatct gtgataaagc tcccgtcccg 2167741 gagcaccgtg aagtccagtt tttcgtctga aagcagatcg ttgccgaatt gaatttgatc 2167801 tttcgtatca atccctaaaa gattcatcag cgtcggcctg atatcaatct gcccgcctac 2167861 tgtttcaatg gtttgcggct ttttatcagt aatacccgga atatgaatga ccagcggcac 2167921 tttttggagc tgtacctctt caaatggggt tatttctttt cctaaaaact gccccatcgc 2167981 ttcattatgg ttttctgata taccataatg gtcaccatat aatacaataa cagagttgtc 2168041 gtataacccg tcttccttca gcttttcgat aaaccgtttc agcgcctcat cctgataacg 2168101 cactgtcgga aaatatttat ttagcgtctg gctgtttgaa tcatattcat caatcaattg 2168161 atcctcttca tcaagatcaa acgggaagtg gttcgtcagt gtaatcagcc tcgagtaaaa 2168221 cggctgaggc agatttttca tcagctctga ggactgctca aaaaattctt tatccttaag 2168281 tccccagccg actgaatttt cgtcagttac atcatacgag ttaatatcaa aaaacgaatc 2168341 atatccaaat gagtcgtaca ttaaatcacg attccaaaag ctcttattat tagcgtggag 2168401 caccgctgaa tagtatccgc tgtttttcaa aatttcagga gcggccatat attgattgcc 2168461 cgcattcgta aaaaatacgg cacctcgtcc aagcggatac agtgaattgt ccacgataaa 2168521 ttcagaatcc gaggttttcc cctggcctgt ttggtggtaa acattattaa agttgtagct 2168581 ctgttttata aagtcattca gaaaaggcgt gatttcttct ccattcaatt tttcattaat 2168641 cacgaagctt tgcgtcgact ctaaggatac gagaatgacg ttccttcctt ttgcagcgcc 2168701 gaataagcgt ttgttggcat ccttcgcatt agcggttacg tagttttcaa tctccgtcag 2168761 gctgttgctg tctgccaacg ctctctgtgc ggattgcttt gactgaagaa cgccatcgta 2168821 aatatgaaaa ttaaacaggc taatgttttt aacaagcatt tctctgtcaa atgagcgtgt 2168881 caatagctga ggtctttccg cctcagacaa gcccaggttg aagaaataaa cagaagcaac 2168941 gaacaaaaaa taagccgccc gttcattttt cgttgaggga atgtccgatt gaaaagcttt 2169001 ttgccggatg tgaagccata ttaaaaccgc aatatctaca gctaatagga ggtctgtcgg 2169061 ctcaagaagt gttccgatgc tgcttccgag atcacccata ttgctcgttt gaaaaagaac 2169121 agggattgtt aagaaatcat tgtaaaaacg gtaaaaaacc atatttgcca gcaatacaaa 2169181 cgtgacaaga cagctcatcg cgataatgta gcgatttctg tttttgcctt ttaaaaacag 2169241 gctgaggcca aaaataagca acaaaaaact caatgggttg ataaacagaa taaattcctg 2169301 tgttagattg tcgattttaa tatgaaaact ggttttgtaa acagcatacg ttttcagcca 2169361 catcaataaa atggcaatca gcataaatga aatcttcgaa aaaaacgttt ttcgcatttc 2169421 aacctcctat gcagcacgct caaaaaaatc agtctattcc caacattctc attaacacat 2169481 caaattaaat cttaacctga gcacaacaaa aaatcaattt catttacaca attttaacaa 2169541 ttttgatgtt tcagccattc atttttagcg atccaagcgc ctccgataac gccggcatca 2169601 tttccaagtg ctgcgattga aatatcagca gcttgggctg cccgcggaaa cgcgcatttg 2169661 cggaatgttt tctcgacttt tgatctcagc agttctccgg ctctcgatac gccgccgcca 2169721 agaacgattt tggatggatt aagcgagctt gccaaatttc cgagcaccaa accaagatgc 2169781 ttggctacat aatcaaccac ctcaagggca atttcatcat tttcacccgc cgcttcaaac 2169841 acatctcgcg ctgacaattg ttcggttgct tttaaacgtg tcgtcttttt agcatttgct 2169901 attttttctt ttgcaattct tacaattccg gttgctgacg caattgtttc gatacagccc 2169961 gttttgccgc agttgcaggg cgctccgcct tcagggatgc tgcaaatatg gccgatttct 2170021 ccgccggcgc catttatacc atgtacaatt tcaccatttg caatgatgcc gccgccaact 2170081 cctgtgccaa gcgtcacgag aatgacgtct tttgcgccat cacccgctcc cttccacatt 2170141 tccccgagcg cagcaatatt cgcgtcattt tctataacag ctgggatgcc ggtttctgtc 2170201 tccagatggt ttttcaaagc ataatttttc caccctagat ttactgtttc ataaaccact 2170261 cctgccgcca tatctacagg gcctggtgca cccattccga tgtatttgat gatgtgcttc 2170321 ggtttttgca gctcatccag cttgctgtcg attgtttttg caattgtgac agtaatcgtg 2170381 tcgccggttt tatctgtcgg aacttcccac ttatgctgaa tttcgccata ttgattaata 2170441 aaagcgagtt taatcgtcgt tcctcccagg tcaatgcccg caaaccatat ctcgtccatt 2170501 tttatcacct tagcctttat aaaaatctct tccgtttttt gtttgttcca attcttttcg 2170561 aaggacagct gccgctctgg cccactgctc cttttcaatc atgtggttca tgtataattc 2170621 ctttaattca tccagcataa actcaatttc aagctctctg tctccaaaat aaacaatgtg 2170681 gccaaacgtt tttaacagct gctgcacatc ataaaatgta ttcattttcc tcaccatttc 2170741 ttgaacttaa ctatcataag cgtattcata aggaagcggt cagtcaagaa gaaaacgctg 2170801 acaaaaaagc cagcttcctt tccatattcc acctctatga ttctttattg ttttcaattt 2170861 gccgctgcag ctccttgtag cgctgctcct tcggcttcag tttcacagcc gtctggatgg 2170921 ccttttctgc ttgtgcaagc tcattttttt ccgcatacaa taacgctaaa ttgtaatagg 2170981 aagcatggtc tttaggttct tttttcactg ctcgttccaa aagggaaacc gcctgatcat 2171041 attcgccgat ttgaatatca gaaacagcaa gaattttcaa aagatcggca gaggcatctt 2171101 tttgcgctgc ttctccgttc agcaattctg ttacttcttc atactttcct tcctgataca 2171161 gctcgcttgc ctgctgaatc agcgctgact cctggtgtga aggcgaatgc aatccgtaat 2171221 ataaaaatcc aacagccaaa gcaatcagca aaaccgctga caacaatctt tttccaaagg 2171281 ctccggcttt aggcaacccc agtgctgctg cagcgaaaaa gccgccaatc aagccgccga 2171341 tatgtcctga attatcaata ttcgaaaccg caaaaccaaa gcccagattg atgataataa 2171401 tgacaataat attggttcct atagttctta aaaacatttt tcgattagac aaagcaacat 2171461 acagtaatgc acctaagcat ccgaatatgg ctcctgatgc ccctgccgaa ggatacgggc 2171521 tgaacacaaa actcgcaatc gaacccgtaa tgccagcagc cagataaatc agcaaaaatc 2171581 tccccgatcc atacatccgc tcaaccgctg taccaaccga ccataaagcc agcgtattaa 2171641 aagctaaatg cgctatgccg atgtgaagca cgatcggtgt cagaagccgc caccattctc 2171701 cttgtgcaat caggctgttt tcttttgctc caaaagccac cagtgtctcc gtattagtgc 2171761 tgcctccgtt tatttcgagc aagaaaaaca tcaggatctg aagcgcaata aataaatatg 2171821 taaaagtcgg ttttccgttt tgaaaaaccg ccgcttcagt ttttctctgt tcttcttgtt 2171881 tcagcactag cgaaaggaag cgttctcgcg ccatttgcgc gttttcaaac gaagcgtgtt 2171941 cctctgaaca atcttctgta cgaaatgatg gaaaaaccgc ttgaagatca tctcgaagca 2172001 tcgttcctct aacgatcgcc ggctcaactg acacagttcc cttctcaaaa gttttttttg 2172061 caatctcttc ccagtcatca actggggctt ccgttgaaaa aaacacgttc agcagcttca 2172121 tccttcgtct gcccaattga tgtctgactc gttctactcg ttcggcctgc tcttcgatgt 2172181 ctctaaccat ttcttgacgg aaatcaagat cgtgcttata aagacgaact agatcatgag 2172241 aggacttgtc cggcgcttcc agccatattt catctgactc accggcttgt atgacgccat 2172301 acccgctatt caccaggtgc gccgcaattt tccaatatgt atactccagc aaaaacatgt 2172361 ttaccgctcc aatagttttt tttcattata acagctggcg ctccgaaacg cctactgaaa 2172421 gcaaaaaatc ccgtttttca cgggatttta gaaagcttgc tgtataaact tattgcggat 2172481 aaatggaatt cttaaaaaca aatggataaa agaccgcctg attcctggct ggctgagtac 2172541 agtattcata agacggtagc gattttgata aaacatgacg gcagaaaccg cgaaaatggc 2172601 atatatcaaa agttttttca tgatatccct cctgccaata gggtttgtta ttctacctta 2172661 tttattctcg aataagggac aggaaagtta tgaaaaacaa gaaataatcc gatcctctgt 2172721 tatcagctta tgtaccggga tgtcatgcgg cagacggggt acgtgcgcaa acaactggca 2172781 ctccaaaagc aaagagactg tcttcccttc atattcactt aaatagcgat cataatagcc 2172841 gcctccaaag ccgaccctaa acccgttaac atcaaaacaa acacccggaa cgatcatcaa 2172901 gtcaatttgt gatgggttta cttcttttgt tttttcaatt accggctcga gcagtccggc 2172961 gtacacggtt tcgagctgat catcagtctg atatgtgcga aattgcattt tcttcgtgtc 2173021 cggatggcat tttgggatgc aaacttgttt cccttcttcc caagcctgct caatgacagg 2173081 acgcgtcggt atctctaatc ctctggaaat agtgacggca atggtgccgg cattttgcca 2173141 ctccggcaga gaaaacaagt acttatacat acgttccgtt ttttgaagaa tatcttcatt 2173201 tgataaagca gacagtgcct ccagcgtctt ttttcttaat tgtgatttca tctctcatcc 2173261 ccctcggaat agaaaaaaag ccagaacctt tttcaaagct ctggcttttt tcttacacct 2173321 caaacagcaa agctgttatt ttgtttcacg gtgtaacgta gattttttat cacgtgggca 2173381 atatttttta aattcaacgc ggtctggatt gttgcgtttg ttctttttag aaatatagtt 2173441 acgctcacca cattcagtgc aagccaaagt aatattaacg cgcattattt tccctccaaa 2173501 ctaaaatcat ttacttattc agacttatat ataataccac tataatggac ggaatgctag 2173561 gctgtttttc aatgaattgc tgaattattg aagatacgct cataaagctg caaatatgat 2173621 gacataatga gtcgggggtg gtggagcttg aacacttgtt gtctgccagc ttcttttatc 2173681 cggcgggctt tttcccggtc ttttaaaaaa ctgtccagca gatcagcagc ttcctgtacg 2173741 agcgtaaaat cagcgatgat tgccgttttg tcatgaaccg cataatcaca aaaaccacct 2173801 gactgagaaa cgacagtcag cacaccttgt tccatgcttt cttgcgcggc aagcccaaac 2173861 ggttcataag aactagggaa aacagccatt tcacagtgag acagtaacgt tctgatatct 2173921 ttcctattta gaaacggcag aaacatgacg cgatccttca ggttatatgc cgcagccaat 2173981 ttctcatagc aggacagaga cggcccctcc ccagccagca ctagatagag gtcaggctga 2174041 cgctgcttca agatggcaaa cacctttaac agctgcgata atcctttttc cggaacaaac 2174101 cttccatatg aaaagaggaa tcttctattc atgcttctcg ggattttccc cttctcttcc 2174161 tccatagatg cagggcttgg gataacggtt attttcttat gtgccgcctt atcaagagac 2174221 cgcttcataa atgtgcttaa tacgatcaat gcatcagcgg attctataag gagccgttcg 2174281 gtcatgagcc tgtatgggtg tggggcttct cggcacacct tcttcctttc gctttcaaga 2174341 ccgtggattg tcgcagcaag cggaaggcca agccgttgtt tcaaatactg ggcggcaggg 2174401 gcagttgtgt catcatgggc atgaatcaga tcaaagcgtt tattgtgtga taacacatgg 2174461 cgaaccattg taaagttagc atcagctatg taatcttcaa acttcgcata cgaaaacagc 2174521 tgcccgctcg gagtaaaaac cgtaatgttg atatgagggt ttaaatagga aatgaggcgg 2174581 tttaaatgga caccgagccc gcttttcggc tcatcgggat gttcgggtga aagcatgaga 2174641 atgttcaccg ttctttttcc cctctcccat aacaggtgta tgcagaaaat tgcgcctccc 2174701 acctggtgtg cgcttcttca atctgaaaac tgtttatatg acgaatccca ttttcatcaa 2174761 gatagatgtc gtctgtaccg gcaagcttga gagagacatt cattgaattc acaattctgt 2174821 attcagcccg atatacagca tcaccagccg cctgtctaat cgtccattct cctttatcat 2174881 acgttgtgcg ttttgtcctg acagcttcaa tgtcttttct tttgatgaca atgcgcaatt 2174941 cttttatcat atcctgcgtt ttttcgaaaa ggaccgcttc agccagccgc attgtttctt 2175001 ctgagatttc ccagcttacg gtcaaggtgt gagcgttttg aatgattatg tcgaatgtgt 2175061 ccctaaaaaa ggaaagctta tgtcgtatat tatagggaaa tgggtgttta tccatggact 2175121 cctaacattc tcctttccaa tcgttcactt cgtgttccta ttaaaccatt acatgaagaa 2175181 gaagcgaaga aagatttctc gacaaaatct cgtttttttc gcgaattcct ttagaaacta 2175241 ttggttttat ggtataaaaa agaaggataa aaaaagaata gaaggtgatg aaacgtggaa 2175301 attgctatta ttgcgttgtt tatcgtcagt atagcgctaa ttgcattctc atattctcaa 2175361 agagacccga tgaaagatgt agaacaggag ctcgaaacac tgcagctttc tgcgatgcag 2175421 gaaatttaca agctcaaaaa gaaaatgaca gtgcttgagg aagaattact ggaaacaaac 2175481 cttgtcattc gcaaatcaaa gcagaacgac atcaatcaaa aaatcgctaa acaaatactt 2175541 tctaaatata ataacggtat gtcagctgaa gcgattgcta aagctgaaca tgtatcagtg 2175601 gaagacgtga atacgattat caaagataat gagaaggtgc tcgtatgaca aaacggggca 2175661 ttcaggcatt tgctggcggc atcattttag cgacagccgt tcttgcagct gttttttatc 2175721 tgactgacga agaccaggcc gctgctgtaa aagataataa aacagtaacc gaacaagacg 2175781 tgaacaatta tcttgattct aaaaaattgg tttctgtcaa ccgtgatgaa tatcaaaaac 2175841 ttctcgattc aaaagagaaa tccttaaaca atgacagcgg ctcagacacg aaatcagaca 2175901 aagtcaaaac ctacaagctc accattaaag acggcatgag cacggcggat gtatctgcta 2175961 ttcttgaaaa agagggcatt atctcttcgg ctcaagactt taatgactat gtcattgatg 2176021 ccggctatca caaagaaatt cgtgccggcg agtttaaagt aaaatcagac atgagtttca 2176081 aaaagatcgt aaaaacgtta acacgataaa aaaacaggct gactcagcct gtttttttca 2176141 tccaaacttt cctgaaatgt aatcgagcgt tctttggtcc ttcgggttag agaacatttt 2176201 attcgtattg tcgcattcaa caagctcgcc catgtagaaa aaggcggttt gatcagaaac 2176261 ccttgctgcc tgctgcatgt tatgcgtgac aatgacaatt gtatatttat ctttcagctc 2176321 tagaatgagt tcttcaattt ttctcgttga gattggatct agtgcagatg tcggttcatc 2176381 catcagcaaa atatcaggat tggtcgcaag tgctctggcg atgcaaagac gctgctgctg 2176441 gccccctgac agcgaaagag cggacgtatg caatcgatcc ttcacctcat cccataacgc 2176501 cacgtctttt aatgactttt ccacaatttc ctgaagcttc ttcttatttt tggtgccgtg 2176561 gactctcggt ccgtaagcca cattatcaaa aatagattgc ggaaacggat tccctttttg 2176621 gaataccatg ccgatatttt ttcgcaaatc cacgatgtcc actttatcct ttaaaatgtt 2176681 gctgccatta tagttcagct cacctgcaag ctttacattc ggcgtcattt gaatcattaa 2176741 attcaatgtc ttgataaagg tcgatttccc gcatccggat ggtccgataa tcgccgtaac 2176801 ctcattttca taaatgctca aattgatatt ttttaaagca tgatgctgcc cataccataa 2176861 gttcattcca ttgacttgat atacttcctg tttcattaca gcttcggtag caatactcat 2176921 tgccgccctc ctatccgaat ttcccgttaa tataatcctc tgtcttttgc tttttcggac 2176981 tcgtgaaaat ctgttcggtc tgtccgtatt ctacaagctc gccgtttaaa aagaatgccg 2177041 tccggtcaga aacccgcaga gcctgctgca tattgtgcgt gacaataata attgagtatt 2177101 ctcttttcaa tcctgtaatt aattcctcta tttttgcatt tgaaatcgga tcaagcgctg 2177161 aagctggttc atcaagcaga agaacagccg gcttcatcgc aagcgttctc gcgatgcata 2177221 aacgctgctg ctggccgccg gataacgaga gtgcggatga atgtaaacga tccttcacct 2177281 catcccagag cgctgctttt gttaaacttt cttccacaat ttcatctaaa acagctttat 2177341 tccgctctcc ggcatatttc aatgcatgtg tgatattcgc atagatcgat ttcggaaatg 2177401 gatttggttt ttggaaaacc attccgattt ctcttctcaa gctgacaacg ttaatattgc 2177461 cgcccaatat atttaatccc tcataaagga tttcaccttc cgctcttgca gatggaatta 2177521 aatcgttcat tcggttaata tttctcaaaa aagtagattt tccgcatccc gacggcccaa 2177581 ttaaagcagt caccgcattt ttttcaatat ccatgtttac atgatgaacg gcttgtttat 2177641 ttccgtaata aatggacaga tctttgacct caagcacgtg gttctgcttc ggaacaataa 2177701 cagctcgctc aggtttttct tttaccattt gttcagacat gtttttcgcc tctttccgtt 2177761 ctaatttgcc gtaagctttt tgtagatcat cgtgccaagc catctcgccg cgagattaaa 2177821 cacaagaaca gaaatcacca gcacggcaga accaccgttg gcaatcgctt cagcatccgg 2177881 aatcattcct tgtgtattga cgttccaaat gtggaccgca agtgtttcag cgggcctgaa 2177941 aatattaagc ggtgatgttt ccgaaaacgg gttccactcc gtaaaattaa gacgcggtgt 2178001 tgtcaggcct gccgtaaata ataatgcggc cgcttccccg aacacccttc ctgacgctaa 2178061 aattgctcct gtgatgatag aaggaatcgc acttggaatt aaaactgttt ttacggtatg 2178121 ccagcgtgat acacctaaag cgagagaggc ttccttcaga tctttaggga ctgaacggat 2178181 cgcgtcttct gtcacacgca ccatgacagg aaggttaaaa acagttaacg caagcgctcc 2178241 gcctatgatc gtataacccc agcctgttaa gttgacaaac atcaataatc caaacatccc 2178301 aatgacaata gacggaagag atgaaagcac ctctatacat gttctaatga agtcagttac 2178361 tttgttatta ggcgcgtatt cagccatgaa gactccgccg cccacaccga gcgggattgt 2178421 aatcagcatt gtaataaaca aaatataaaa ggagttaaac agctgatctc gtatgcctcc 2178481 tccagctgca atggcgctcg actttgttgt aataaattga aaactgagct gagaaacacc 2178541 gtttataata atataggaaa acaaacctac taaaatggca gcgataatgg ctgcacacaa 2178601 accaaacatt ccggtcgcca gtttatctgt tattttgcgg ttcattacac tttcctccta 2178661 gatgacaagt agcgaataag caggatgaac aagaatgaca tcaccagaag cacaagcccc 2178721 attgaccaca gcgtattgtt ttcaacactt ccgtatgtgg tgtggcccat attcagcgtg 2178781 atgatcgttg tcagcgttcc cgcagtgtca aacgggcttt ccggcaatac tcttgtattt 2178841 ccaatgacca tctgaacagc caaagcttca ccgaacgccc gagccatgcc taacacaaca 2178901 gctgtcatca atgttggaaa agctgcaggc acaagtactt ttctgatcgt ctgccatctt 2178961 gtggcaccaa gcgcgtaaga accctctcgt aaactcttcg gaagagaagc cattgcatca 2179021 gcagaaatcg atgtgatcgt cggcagaatc atgacggaaa ggacaatcgt tcccgccaat 2179081 aaactgtgcc ctgttccgct cgatttgaac tgggcgataa acggcaccaa tactgtaaga 2179141 cctatgaatc cataaacaac agatggaata ccgactaaaa gctcaatcac cggctgcagc 2179201 actttctttc cccaattcgg ggcaatctct gtcataaaaa tcgcacctgc aatgccaagc 2179261 ggcgcagcga ttagagcaga aagaatcgtt actgcaaatg agccaaaaat aaatggcagc 2179321 actccgtatt tcggatcact atctgtagga ttccaattta agctcgttaa gaattcaatt 2179381 gggcttacac catttacaag aaaagattgc agccccttaa cgccgaggaa aatggtaatc 2179441 gcaacagatg ccgcaatcat aatcagtgca caagctgtga ctatcattct tccccgaact 2179501 tcatccaatt gccgattttg cctagagctg attaagcgct cgctcacaga catattttct 2179561 ctattgttta tcattgtttt acactcctat gaatgtgtta agaggagaaa cggttgtccc 2179621 cgcactcctc tttttattaa gatcagcttt gcttcccgtt ggcatcacgt gtcactttca 2179681 tatcagtaac cggaatgtag ccttggtcag taacaatgct tttttgaatg tcttcactct 2179741 ttagataatc aagaaattct ttagctaaac ctgtcgcttc accttttgta taagaatgtt 2179801 gataagccca gatcggatac tcgccagttg ctacattttt cgcttcaggt ttaacaccgt 2179861 caatagatag agcagttact ttgtcatctg ttaaatatga gaatgcaaga tatccaatcg 2179921 ctcccggagt atcagcaatg atctttttca ccgtgttgga ggaatcttca gtaatgcctt 2179981 ctgcaggctc cgctccgtca agcgcatatt tcacaaatgt agcacgtgtg ccggaagaat 2180041 cagggcggtt tacaagtgta atcttttggt ctttgccgcc gagctctttc cagtttttga 2180101 ttttgccagt gaagattttt ttcaattcat cttttgaaat atcctttaca ccagcatcag 2180161 ggtttacagc tgctgccata ccaactacag cgacttgatg atcgacaagc gcttttgcat 2180221 cgatgccttc tttttcttca gcaaaaacgt ctgaattccc gatctgaaca gctccttcag 2180281 agacttgaga aagccctgtt ccagaaccgc cagcttgtac ctgtatatca gcatcagggt 2180341 tttcttccat aaatttttcc gcggctgcaa gtactagtgg ctgcattgcc gatgaaccag 2180401 aaatggttaa agaacctgat gccttttctt ctccttttgc agaatcgcta ttcgattttt 2180461 tactttctcc tgcatttccg catgcagctg caatcatcat aaaagcagcc atcagaagca 2180521 taagcaccaa tttgtttttt ttcatttcct gaattccccc tgcgtataat gtgtaatttg 2180581 tcctacacgt atagagtaaa ggttctatgt aaaaagggtt tgaaccgaat gttaaggttt 2180641 tgtaaatcag tgcgtttttt tgtataaaaa aaacgcccac atcatgtgag cgtttttttt 2180701 tagttatcag aagacgttgt gttttctgca ttttcttcaa ttttgtcttt attcttttgc 2180761 tgagtacctt ctttgtcctg cttcgatttc agctcaaaat atttatccat tacttccctg 2180821 ccgatttcgt ttgtaattga gtatctttga ttgtaatcaa tgtaagtcca aggaactacg 2180881 acagaaatag caatctcagg attgtcagct ggtgcataag ccacaagcgt cgtattataa 2180941 gtgtctgttc ctgtttttga tttatccggt ccgtcgtaaa atgattgggc tgttcctgtt 2181001 tttgcagctg gtttatacga tgctgaagcc agttgacctg cagctgtccc tttagtggca 2181061 acccgtctaa aaccggcttg gacctcttca atatagctac tcttcatatc gactttattc 2181121 aatacttcag gctgaacaga atcaacgact gcgccgatcc cttttttcgc atttgaatct 2181181 ctgacttcct ttacaagctg aggcttcatg cggtagccac catttgctat ggtggagaca 2181241 tattgagcca attccagcgg tgtataagta tcatactgtc caatggcgaa atcaagcaag 2181301 aaaccagata atctgcttgt acctttatat cccgtcattt catttggtag atcaattcct 2181361 gtttttactc ctaatccaaa ttgactgaaa taatttctga aggtatcaaa tgcagaagta 2181421 tccaaaggca atgcttggtg aggtttatat tcacctttac caactgcaat tgctgtttta 2181481 aacataaaaa cgtttgatga cttctctaat gcagtttgaa taccaaccgg ccctaagttt 2181541 tgccaagatt ttttccctct tttatcctgg ccgatataca atggttcatc cttaaataca 2181601 gtattcaaat taatcgctcc agtttgaaga ccggtcaaaa cggttgcacc ttttacagct 2181661 gatcccatag cgtaggatga agtcatggct cctaatgcat aatcatcaaa cttataggct 2181721 ccattttctc gtttaatctg cttccctgcc attgtcagca cttcgccgtt tctagggtcc 2181781 atcatgacaa cgaatgcacg atccaacaat tcggtactag gtcttgcttt agcagcttta 2181841 agttttttct caataatttt ttccactgat ttttgcaaat caatatcaat tgttagtaca 2181901 agatctttcc cggctttgcc ttcagatacc gtttttgttc ccgtgacatt gccttttgaa 2181961 tctgtgatat tttcgacttt tgctttttgg ccctgcagaa ggctttcata ttggtattcc 2182021 agatagcttt ttccgaccct gtcatttcgg ctgtagccaa gcgacagata atggtcgagc 2182081 aagttggacg gcaatccttc attagagctg gaaacacttc cgagcactga gcgaagaagg 2182141 tttttataag gatattcacg ttcccaatcg gacgtgacat caacacctgg cagttcgtct 2182201 aaatgttcac ttaccactgc catttccttc gctgatacat cttcgttttt gatatattga 2182261 ggggtcaatg catagcccga atccatctgt cttttgatag caaggatctg catatcttta 2182321 tccgtcaatt cattcagctg cttatcagta atccgtttta gctgaagctg gtataaatcg 2182381 tcatcggata tttttttgtc ttcaacctgc tgtctttctt tagagctaat gagctttttc 2182441 gcttctttcg gtctagtcaa aatccaataa tcttttttat cccgttctgt tacttttttt 2182501 gtatcgactt tgatcatgtc agacagcttt tttgcgatct ttaagcgctg ttcttgcgtg 2182561 gtcgatttag atctcgtgta tgtgattgca tttaaagcct tatttgtcac aatggcatta 2182621 aagtttcgat cataaatttt cccgcgtggt accgctgagc tgacttcact ttgttcctgc 2182681 ttattcgctt ggtttttgta atcatcacct tgcacgatct gcttgatgcc cagttccaca 2182741 ataatccagg taaatataac aaaggcagct aaaaataaaa tattcagccg gatcggaagc 2182801 gacttctttt tctctttatg attttgcttt tttggtttat ttctcctcat aacatcacct 2182861 tttctattta cagaaagaaa agacactcaa gtaagagtgc cagttttcat tttaaaggtt 2182921 ttttcgactt ttttctacag ataacccctt tttggcaaaa aaattatctc tcgcctttta 2182981 aaagggtcgg ttctgttacc cgtttttggc cgtcttcttc catggtttca ttttcccctt 2183041 ctttctcctt aaaacgaata tccttgacaa agtaataaat caaaggatgt cctataccca 2183101 atatcgcaag tgacaaagga attcccacat cctctttcag aagggccaca atcaggagaa 2183161 agcacaaaat ggaaacaatt ctgccggcgt tcaagaacat ttctctaagc acgatatatt 2183221 caattcttgc ttttctggca tgcctcgcgc gccctatcac atcatatgta agtgatacat 2183281 atggcacaag caacagagga tagccgatgg caataaaaac gccgtacgtt aataatgtcg 2183341 aaaagctcat atggaacaga atcaaaaaca gcgcgccata caaaataagt ccgcccagca 2183401 aaatcgattt ttttctcgcc tttttcttaa tcagcctgga tgcaaagtag taggcaaaga 2183461 aggaaacagc tgaattgaca agaccgaatg taccgagagc aagctcgctg tttgtctcaa 2183521 taaatacaaa cacactgatt aaaaagacaa aaatcccttc tctcaaaccc tgaaaaaaat 2183581 gcgcattcgt gattctccgc caattcatat tgctatggcg ctctccaaat actttgctca 2183641 gcataaaacg gccctttgat tctctccgtt ttaagaaaaa gctcatcacg acagccaggg 2183701 caaataaact gagggagaga ctgaaaatca ctgtataacc cgtattattt tcaagccttg 2183761 agatcacgaa tccggctaca atcgggccga tcattcctgc agaggaagac agaatgccca 2183821 taaacccgtt gaaaaagtct cgtgtatccg gctctgttat ttcaaaggtc agcacgttaa 2183881 acgctagcca ataaaagcca tagccaactc cgagcaccgc gccgattagc acgaggcggc 2183941 tggccgccgt ttctccggct aaaagcacac ttaaataaaa ggcagctaaa aaaatgacgc 2184001 cgaaccttaa aatgaatacc ctgtctattt ttttggctaa ccgtccagcc aaataaaagg 2184061 ttatcggctg cattgtcaca atggataaat tatatatcgc caaatcaata aatttccctg 2184121 actgcttcca aagatacaca ttaacaaatg tattggacag tgcaattccc agcgagtaaa 2184181 gcccgccaat ggtcagcaga aagagtaagc ctttgtttac gtctacatcg cctatcactt 2184241 tttttagttt gctcattact gactcccctt tactatccct tagtctgtct cactcaaacc 2184301 gagatatgta aaaagaagac ataaaaaaac aaggtcccat aatgaggacc ttgtttgtgc 2184361 cattattttg cttcgctgta tagacgagcc acttcgtccc agtttacaac attccagaaa 2184421 gctgaaatgt aatcaggacg gcggttttga tagttaaggt agtaagcatg ctcccaaacg 2184481 tcaagaccta agataggcgt tttgccttct gaaagcggag aatcttggtt tggcgtgctt 2184541 gtgatttcaa gtttaccgtt gttcacaaca agccatgccc agccagaacc gaagcgtcca 2184601 gctgctgctg ctgcgaattg ctctttgaat ttgtcaaagc ttccaaatac actgttaatc 2184661 tcttcagcaa gcgcgccagt cggttcgcct ccgccgtttg gagataaaag tgtccagaat 2184721 aatttgtggt tcgcgtgtcc gccgccgttg ttgcggactg cagtgcggat gttttcagga 2184781 acagaatcaa gatctgcaac aagctcttca actgatttgt tggcaagagc agtgtttcct 2184841 tcaaccgctt tgtttaaatt tgtcacgtat gtgttgtggt gtttcgtatg gtgaatagtc 2184901 atagtttcct tgtcgatatg cggttctaaa gcatcgtacg cataaggtaa ttctggaagt 2184961 tcgtaagcca tgataattcc tccttagtat atatgtactg aaatgccgct tcacagcgag 2185021 cctttcttca ttcaatgtaa caaaagaatg ctttgtaatc aatgaaaaag ctcacgattt 2185081 ggctcatttc agcggacata tttcacttta accgataatc tgccccatta aacctgccgc 2185141 cagcatttct tataggaccg tccataaaaa gtaaccgatc atcaaaagct gtatgatgcc 2185201 ctttgcaata acccctgtta aaaaaccaat gagtgagccg aggccaattt taaacgctga 2185261 ctttaagtcc ttctgatgga cgataagttc tgcgcaaaca gccccgataa acggccccaa 2185321 tatgatccct gcaaccggaa tgacaaaagg cccgattaat aaaccgatcg tgcttcccca 2185381 tatggcagct ttgcttcctc cgaacctttt tactccaagc agattcgaca cgtaatctgc 2185441 tgcgaataat actgcggcaa aaactgcctc aacaagccag aacatataag aatacggact 2185501 gaatgaaaat aaaaatccgt acaatacaaa tccggcaaca ataaatacta cgctaggaat 2185561 aacaggatac accagcccga taaaggcaat gataaaaacc gctgcaatca acagccaata 2185621 caacatatcc atagcttcca tcctcccatt ttactctgtc ttcttcatgt cttccttgta 2185681 ttcacacgca tgcaacgata caataagcaa catatattag tttagctagg aagtgaagat 2185741 agtgaatgtg tttcagcttt tcattaaaag tacatactct ccccgtgata ttgcaaaaac 2185801 aagatttcaa ggaatcggaa aagcgattct ttatgtattt ttgctctctg tcctgtttgc 2185861 aatccctacc gcttattatg taagtacagg gaccgtaaaa tcaatgaacg gctttaaaac 2185921 tgttttaaac aaagatttcc ctgatttcac aatttcaaac ggcaaacttc aaacggatga 2185981 gaaaaaagcc acggaatctc aggcaaatgg tttcgttatc gtgttcgatc cgacagactc 2186041 ctatggcact gaacaaattg aagcaaagca aaacgcaatc ggcatccttc agaacaaatt 2186101 tgttttggcc attgacggac aagcccaaga aatgtcttac tcaatgatgc cgtcagagtt 2186161 acagaaaaaa gatgtcattg caggtttaaa ccaaaataaa gcgatgattg taactgttct 2186221 ctcagctctt atttttctcg taacagcagc gggaaaattt attgaagtat cgtttttagc 2186281 gcttatcggg ttaatcatta agaattcgca gaaaaaacat ttatcctatc atcagctctg 2186341 gaagctttct gcttattcca tcacactttc aactgtattc tttacaatca tgcgggcact 2186401 agaagcaacc gtaccaagtg aatttttgct gaactggttt gtcaattttg tcatcctgtt 2186461 tctcgtttta aaagagattc cgtccaaaaa agtaattaat aaaagttaaa ttatatttat 2186521 ttttatcctt taagtagaga gtgtgaaagc atttgcatta actttttact taagggatat 2186581 ttaataaaat gtatagagct taaacagata catttataaa aaaagctcta caattactca 2186641 agaacaagct ctggacaata atatcagaag tagtaagatg taacatgaaa gaagttctta 2186701 acagcatttg acatatgttt ttaacaaaat aagaataatg ttaaatttta actaatagac 2186761 tagttaaaat catatggcaa aatattttgc atcctttcac aacatattta cataagatag 2186821 ttgctattta aaaagccagg taccaatagg gcacctagct ttcagaatta aatcatcaac 2186881 aagttagaat tatcttcttt ccttctattc tcattattga actgttatct tttttgtggg 2186941 tttatgtata caaatgcagc tcccttagct ttccccttat atactgataa acctactgcc 2187001 caaggtgttc ctgtcggttt tggtaattta ctgaagtaaa actttttggt tggagttcta 2187061 cttgaaaagt accctgaata ttgcgggcca atgtccccac cctcaactat agatacacca 2187121 aagctcttat aatttagttt accgcatttt ccatttgttt cggcgtaagc atcaatagat 2187181 gttgcactct tagtatatgt ataagcatct gtaataactc ttattttaca accagaaata 2187241 ccacttaccg gttgccaacc actgcttgca gcctctgctt tttctttagg tgcaactacc 2187301 aaagttaaca ttagtagcaa aattaaaaac acagaaaatt ttccttgctt cattttgtag 2187361 atcctccttt aaactattac ataattatcc taacagatcc attgttcatt gtaaataatg 2187421 gaatacgagt tttatattat aaaagcctct ttttgatcta attttgcact attttctatt 2187481 ttctatctga agttaatgtt tagtcgaaga aatcctgtca aaaaagcgcc tgtataaaaa 2187541 ccgagcattc gcagtctctt ttcttttgtc atgaatcgaa atggacaagc atactatggt 2187601 ataaaatttc gtatgcggga ggaaaagcga tgaagcgtct caccttagta tgcagcattg 2187661 tttttatact ttttattctt ttttatgacc ttaaaattgg aaccataccc attcaggacc 2187721 tccctgtcta tgaagcatca gcaaaaacgg ctgtacaaga accggcttat aaaacggtga 2187781 aggtaaagcc gggtgatacg gttatgtcga tagtcggatc agcaggttct ccggatgaca 2187841 ttgtaaagga ttttgaagca ctgaatccaa atgtgaaagc taacgccatt caagccggaa 2187901 cagcgtataa attcccggtc tacccttaat ttaacgttaa tttcttgtca gttcggcgaa 2187961 gacactgtta caatgtaatt tgtaaaataa attcacataa accatactag aattgttata 2188021 tctagaagcg gcaactacaa ttaaggagcg attgcaagtg agtgaaatca cacatcgtac 2188081 aaaaacgcgt cccgtcaaag tgggaccttt aacaataggc ggcaacaatg aagttgtcat 2188141 ccaaagcatg acaacaacaa aaacacatga tgtagaagca acggttgcgg aaattaaccg 2188201 tttggctgaa gccggatgcc aaatcgttcg ggtagcatgt ccggatgaac gggcggcaaa 2188261 cgccattgcg gatattaaaa agcgcatttc cattcctctc gttgttgaca tacatttcga 2188321 ttataaactt gcgttgaaag ccattgaagg cggcgcagat aaaatccgaa tcaaccccgg 2188381 caatatcggc cggcgcgaaa aagttgaagc ggttgttaaa gcggccaaag acaaaggcat 2188441 tccgatcaga atcggagtaa acgccggttc attggaaaaa cggattttag aaaaatacgg 2188501 ttatccgact gccgatggaa tggtagaaag cgcacttcat cacattaaaa ttcttgagga 2188561 tcttgatttt cacgatatta ttgtcagcat gaaggcctct gacgtgaacc ttgcaatcga 2188621 ggcttatgaa aaagcagcga aagcgtttga ctacccgctt cacctcggga tcaccgagtc 2188681 aggaacactg tttgccggca cagtaaagag cgcagcagga ctcggcgcca ttttaagcaa 2188741 aggcatcggg aacaccatgc gcatttcact aagcgcagac cctgtagaag aggtaaaagt 2188801 agcaagggag cttctgaaat ctttcggctt agcctccaat gctgccacgc tcatctcatg 2188861 cccgacttgc ggccgtattg agattgatct aatcagcatt gccaatgaag tggaagagta 2188921 tatttctaag ataaaagcgc cgattaaagt tgctgttctc ggctgcgctg taaacggacc 2188981 tggtgaagcg agagaagctg atatcggaat cgccggcgca cgcggtgaag ggctgctgtt 2189041 ccggaaaggg aaaattgtcc gtaaggttcc agaggaaacg atggtagaag aactcaaaaa 2189101 agaaattgac attcttgctg aggaacacta cgcaaaactt gaagctgaaa aagcaaaatt 2189161 aaaagaagaa acacaaaaag cttgacggga acccgtcaag cttttttgtg ttagaaaaat 2189221 ggaataataa atattccaag cactaatgaa acgacaccga tacccattgc ccaggctcca 2189281 aggccttgag cacctcttct tcttgcgata tagccgacaa taataccagc agctcccaat 2189341 aaaacaggca gtacaaacaa tgaaatgatg gacaaggcta aagcgatgta ccctattccc 2189401 cgtccttcat tgacattgcc gccgctgcga tcattgtctt ggtcattgct gcggtcagca 2189461 gcacgataag gctctgcgat ttcagcagct gtttcctcaa aaaaaccgtc attgtcgcgg 2189521 gtaatatttg tcccttcaga tccatgatca acatagtaac tgttgttatc acgcttttcg 2189581 taatcgtttg ccaccttcaa ttcccccttc tgttttatta aaggagcttt tatagtttga 2189641 tccattttgc ctgattcatg tttgctaaac ttttctgtta atgtcaattg tttatgttac 2189701 acttgaaggg atgaaactga aggagtgtgg gcatgttacg cttaggaata gatattgacg 2189761 gcacaatcac ggctcaggat acattcgtcc cttatttgaa ccgttcgttt aatctttcca 2189821 tttcattaaa cgatatgacg gattatgatt taacaaagct gttaaacatt acccaggaag 2189881 aattttggga ttggatgaat caaaatgaag cgatcatata taaggaagca ttgcttgcac 2189941 agcatgcgaa acagtctctc gatcttctca aagaggagca caagcttatt tatattacag 2190001 cgagacggac tcatttaact gatattactt atgaatggtt tgacagacaa aacattcatt 2190061 atgaccacat cgaacttgtt gggggtcatc acaaagttga agcggtcaag aatcataaca 2190121 tcgacctgtt ttttgaggat catcacggga acgccatgat gattgcgaaa gaagccggga 2190181 taccggtgat tttgttcaat tccccttata atcagcttcc gattgattca aacatcatca 2190241 gagtaaacaa ctggctagaa gccgttcaat ggatgaacaa caacaagcat cacttaatac 2190301 gcgtcaataa ctgaaaaagg agcccaaacc gggccccttt ttcatatata cgcattttac 2190361 gcagtagtgt tttcttggtt ttccgctgta caatcagggc atgtgccata aatctcaaat 2190421 ttatgcccgc tgacctgata gccatccaaa tcatcacaaa gcttgtccat cggacatgat 2190481 tcaatttcct ttgttttgcc gcaggcaaga caaataaaat gatggtggtg atgggtgaat 2190541 gaacacttaa atcggaagag cttttcaccg gacagctcag ttgtttccaa aatcccaagt 2190601 tcttcatata aagaaagatt tctgtagatt gtatcaaagc ttaagcctgg ataatcatca 2190661 ttcagtgcag acagtacgtt tttagcggta agatatctgt ctgaatcagc aaaaagctgc 2190721 agcatatcct cccgtttgtt tgtatattta tatccgtttt cttttaatag gttcagcgct 2190781 tcttggacgt tcatgaaggg tccccctttt cgctttgctt aagaacgtat cacatgtatg 2190841 aaaaagaaaa tggcagctgt ctgtccagca agccattttc tttactgcag ataaaattat 2190901 acccataaaa tgaataaaag taaatgaaag cctagtggat tgcgtttttg aattttccgc 2190961 ctctcgtttc atgagtattc ataattgtta tgaatgcatt ttgatcaact tcaaacacga 2191021 tcgatttgag ctttgtcact tccagccttg tgacaaccgc gtaaattacg tctttttctt 2191081 cgtccgtata cccgcctttc cccttcagct tcgttgtgcc ccgaccgaga cggtgcaaaa 2191141 tcgcgtcgga aatctcatca tactgctcag acacaataat gacagctttt gtttcatcaa 2191201 gcccttggat cacggcatca atcgttttca tcgcaatata ataagtcatg aatgagtaca 2191261 tcgcttgctc aggaccgaac acaaaaactg cccaaatgaa aatgaacaca ttgatgaaca 2191321 taacgaactc acctacagaa aacgggagtt ttttggtcag caaaataccg agaatttctg 2191381 taccatccat tgaacctcca tttcgaataa caagcccgac gccaaagccg agtaaaagac 2191441 ctccgaacac agtagccaaa ataggctggg ttgtaatggc ttctacatgg tgaagtgagg 2191501 attcaataac ggcaagcccg acaatcccta taaacgtaga gactagaaag gtcttaccga 2191561 tatatttata tccgaagatc ataaaaggaa tatttaatat gacaacgaaa aaagcgaaat 2191621 tcagaaaggg gtttgacata aagaggtggt ctaaaataag agatacaccg ataatcccgc 2191681 catcaataaa atcattgggg attaaaaata attcaatact tacagccgca gatgcagctc 2191741 ctaccagaat cataaagacc ctgaaaataa aatgggtaaa tgtttctttc ttatgttgtt 2191801 ttgttggggt cataaaatct cctttcctgc aataactatt ttaaatacat tataaatcta 2191861 ttttaccatt aaacactgac acattttact gatttgccca tacattaagt ctggaggtgg 2191921 aatgaccgat gattttattt caaagaatta ttttgcagcg gcttaatcag gctactgctg 2191981 atgatttgct gaagtactca aaacaatacg gaatcagctt aacaagatcg caggccgttg 2192041 aagtagcgaa cctgttatac gggaaaaatg taaacatctt taatgagagt gaacgaatgc 2192101 ggctgctgaa acaagtagag acgattacat cgaaagaaac agctcaaaca gttaatgaac 2192161 tattcaaaca atttacaagc taaaaaatgg gggtgttatc ccccattttt tattgctgta 2192221 aaatcttttc aagcaatgta tcatcaaatt gtttttcttt cagcatttca atctcaaaac 2192281 ggtatggcgg ttttttgttc tttttatctt caccgacgta tggtgtttca agaatttttg 2192341 gaatgtcttt taactgctca tggtgaacaa catattgcag tgcgtcaaaa cctatttcac 2192401 caaagccaat attttcatgg cggtcttttc tcgcaccttt gacatttttg ctgtcattga 2192461 tatgaagcac tttaatacgg tcaatgccaa tgattttatc gaactcattt agcactccgt 2192521 caaagtcttc gacaatgtta tacccggcat catgtgtatg gcacgtgtca aagcacactg 2192581 acagctgctc attgtgtgta acgccttcga taatctgcgc aagctcctca aagcttctgc 2192641 cgcattctga tccttttcca gccattgttt ctaatgcaat ctggacattt tgattcggat 2192701 caatcacttc atttaagcct tcaataattt ttttgatgcc ggcttcagct cctgccccta 2192761 cgtgagcgcc aggatgaagg acaatttgct tcgctccgat ggccgctgtc cgttcaattt 2192821 ctgaacgaag aaaatcaaca cccagctcaa aagtggacgg atttgtcgtg ttgccaatat 2192881 taataatata aggcgcgtgt acgataatct cgtcaatgcc gttttcttgc atatgtgccc 2192941 ggcctgcttc tatatttaag tcttcaattt tctttcggcg cgtattttgc ggtgcgcctg 2193001 tatagatcat aaacgtattc gccccataag agactgcttc ctggcttgca gccagaagca 2193061 tatgttttcc gctcatagag acgtgtgagc ctattctcag caacaggttc ccctactttc 2193121 ttttcttaga ttggtttctt ctctgttttt tcttgatttt ctccatctca tagctcattt 2193181 tctttttata cccaggctta accttcttcg gctttttcac gagacgatga gcaatttcat 2193241 ccgcttcatt cggcgttttt ttacgttttt tgcggcgctg acggtcatcg ccttttttcc 2193301 attcgccctt ttcaagctct aagtactcaa attcgatgcc cattttttca agtcttacta 2193361 atgcatcctc atcagtaagc tcataaatgg tcatcgcttg tcctgatgag ccggcacgag 2193421 ccgttctgcc cacacggtga acatagaaat cgagatcatc cggcagctca tagttgataa 2193481 catggctgac acctttaata tcaatacctc ttgcggcaag gtcagttgca atgatatatg 2193541 tgaattccaa atcattgatc tgcttcatga cttttttccg ctcacgtggt gttaatccgc 2193601 cgtgcagcaa gccgattttc atgcctttgc cagtcagata ctgggcaata tggtcagccg 2193661 tatttttcgt gttggcaaac acaatcccca ggtatggatt cagatgcgac atgatgtcaa 2193721 aaaggagctt gtccttgtca cgatgtttcg aaggaatgag gatatgctcg attttcgcag 2193781 cagtcacctg ttttggctcc acatgggcgt atttcggatt ttccatgtat ttcttcaaga 2193841 atggtttcag cttttccggt atggtcgctg agaacacaag catttgcaga tcctcaggca 2193901 tgcgggaacc gatgtaatct acatctgcaa ggaatcccat gtccagcatt aaatccgctt 2193961 catcaataac aagagattcc gctttatgaa cacttaacgc ctgttctttg attaagtcag 2194021 caatccgtcc aggtgtaccg acaacaagat gcggctgtat tttcaattta tcaattgatt 2194081 tttgtttatc agtgcctccg ataaaacatt tcgagcgaat ctgacttcct tcttcaccct 2194141 gcgtgatttt aagcgcttcc tgataaatct ggttggcaag ctctcttgtc ggagccgtaa 2194201 tgactacctg aacgacatcc ttagcaggat cgattttgtt taataaaggc agtaaataag 2194261 cgtgagtctt tccagtaccc gtctgagact ggccgatgac gctttctttt tttaacactg 2194321 caggaatcag ccttttctgg atatcagtcg gttcgtaaaa accaaggcga tgtactgcat 2194381 ctataataaa tggtttcaat tcataaagtt caaatttcgt ttctttcatt tttcccagct 2194441 ccttaaagcg gcacattatg tgtccatcat cacattatac ccgattttgc ttaaaaacac 2194501 cacgtttgca aggcgtttgt tttattcagt tatgtaaagc aaataccgca gcccatgcat 2194561 attctaatag cagagagagc tgaaaggagg tacaagtatg ttttcaccgc agcagccaat 2194621 gagaaattac ccacagcccg gaccgccccg ccccatgcca aatcagcgaa tgatgggcag 2194681 aagaccgcct aatatgcgag gaccttcatt tggagcacag cagcaaggtt ttcagcaagc 2194741 cggacaattt cttcctcagg caaatgccgg agcgagaaat ggtgcaggtg caggcggagg 2194801 cttaaaagga atgctgtcaa ggttcctccc cggcggagga ggcgctggca gcgccggggt 2194861 tcccggaatt ccaggagcag gtgcagcagc gagcggaggt gctggcctgc aaggcattca 2194921 aaatattgcc aatcctgcat cattatccag tatgcttgga aatgtgcaaa aagtactcgg 2194981 catggcgcag caagtcaccc ctatgatcca gcagtacggc ccattagtcc gcaatctgcc 2195041 agcaatgatg aagctgtaca gccaattaag taaaagtgat gatactgaga cagaggccaa 2195101 tgaggaaagt gaaaaacaat ccgtttcaga agaatcatca gaaaaagaaa aagagactga 2195161 aacaaaaacc tcagatggga acaaaaaatc aaaaccaaaa agttcttctc tcccaaagaa 2195221 atctaaaaca actgacaata aagaacaaga attaaaaaca tctgccccga agaaaaagga 2195281 agctgcctct cctgctccga aaagaacatc aggcagttca aaaccgagat tatatattta 2195341 acattctttg atatcttaag tgagattggc tataatgaga tcagaagaat gcaagaatag 2195401 agccgtttga ttacggcttt ttatattgcc tttactcact tcagtattgg aggacaaccg 2195461 aaaatggacg taattaaaat ttcaccgcgc ggctattgct atggtgttgt tgatgctatg 2195521 gtcattgcca aaaatgcgtc gctagataaa agcttgccaa gacccatcta tatactcggg 2195581 atgattgttc ataataaaca cgtcactgat gcgtttgaag aggaagggat ttttacattg 2195641 gacggctcta accgtctgga catcttaaag caggttgaca aaggaactgt cattttcact 2195701 gcgcacggtg tttctcccga agtcagaaga atcgcagaag aaaaagggtt agtcgcaatt 2195761 gatgctacat gtccggatgt gacaaaaact cataatctaa tcttagagat gaaagaaaaa 2195821 ggatatcacg tgatctatat cggcaaaaaa gggcatccag agcctgaggg agccgttggc 2195881 gtagcgccgg agatcgttca cttagttgaa acagaagaag atgtaaagaa ccttgatatc 2195941 caatctgaga agttaatcgt gacgaatcaa acaacaatgt ctcaatggga tgttcacgac 2196001 attatggagc ttgtcaaaga aaaatatcct catgtcgaat atcaccaaga gatttgcctc 2196061 gctactcaag tgcggcagga agctgtatca gagcaggcaa aaaaagcgga cttaacaatc 2196121 gttgtcggag acccgaaaag caacaattca aataggcttg ctcaagtgtc agaggaaata 2196181 gccgggacaa aagcataccg gatcggcgac ttaagcgaat tgaagctcga atggctgaaa 2196241 ggcgttaata ccgttgcagt tacagcggga gcttcaacac cgacgccgat cacaaaagaa 2196301 gtcattcgct ttttagagca gtttgatcac gaagatccat caacttggac aactgaacat 2196361 aatataccgc tcaaaaaaat acttccaaaa gtaaaagcaa aaaactgagg ctgtaaaagc 2196421 ctcagttttt ttatagaaat gtaaatggat ttgtatctgt ttcagaaaca aagatattca 2196481 cgccaaactt tttatcatta cacattgatg taagttttct cgtgacgcct tctttcatga 2196541 ttttttccgc gtaatggccc ggatcaacca catttaggcc aagcatcatc gcatcatggg 2196601 ccacatggaa gtataaatct cctgtgacgt aaacatcggc tccctttcgt tttgcatgat 2196661 gaatatactt gtttccatct ccgccaagaa cagctacttt tttcaccatg ctgtcagcat 2196721 ccccaaccat tctgacacca ttgacgtcaa gcttgtcttt cacaaataaa gcgaattcct 2196781 tgagcgtcat ctcattttta agggttccga cacggccgag ccctttttcg gcgggagtct 2196841 gttcgacagg atagatatcg taagcgactt cttcatatgg atggcttttt atcattgcat 2196901 tgataacagc cttttcgacg cttttaggaa atacagtctc aagccttact tcatgaacaa 2196961 gctcaagctc tcccacttca ccgataaaag gcttagctcc gtccaatggc ttaaagctgc 2197021 cgattccttc agatgaaaac gcgcaatggc tgtattcacc gatatggccg gcccccgcat 2197081 ttccgagcgc ggctctgacc tgctcttcat attccttcgg cacgtaaact gccagctttt 2197141 tcagaggatc cgtataagta ggtgccagca cttccgtctc actcagctct aatgcttcag 2197201 caagcaaatc attcacaccg ccgtccgcaa cgtctaaatt tgtatgagct gcataaacag 2197261 caatatcatg cttcaaacac ttttcaatta accttccggc aggctgatct gttgaaatat 2197321 gctttagcga ccggaaaatt ggtggatggt gtgcaataat caagtcaacc tctttttcaa 2197381 tcgcttcatc gataacgctc tctaacacat caagtgtaac catcacattt ttaattggtt 2197441 tgtttaaggt gccgatttgc aggccgattt tatctccttc aaccgcatag gctttcgggg 2197501 aaaattgttc aaacagctgg atgatctgct gcccatttac acttttagcc atgatcgatt 2197561 acctccttta acagctccat tcgatcggcg agctccttta atttttgttt gttttgctct 2197621 gtatccgccg cttggctgat ctgttcataa atgctttgag tgtgctgaag ctcttgtgtc 2197681 cactttttca aaaagacagc atttttttct tttgccaaga aagggccaac gagcatcccg 2197741 gctgataaag aaataccgtc ataagccgca tccctgtctc ccgcttctgc caccagcacc 2197801 tcatagcact ttccgtcctc ttcaaggatt acctcatcta tcagcgcata tctttcttta 2197861 taaagccact ccctgatatg aacagcatga atattcggct gtaaaatgag ccgttccttc 2197921 cccgttaatt tgtctttgcc cgcttctaaa atgtgagcga tcaaagcccc gcccattccg 2197981 gcaatcgtaa tggcatcagc ttcacctttt ttaatcactt ccagtccgtc tccctgcctt 2198041 acagaaatgt gcgagtttaa gcctgatttt tcaacctgcc gctttgcaga caaaaatggg 2198101 ccgtctgtta tttctccggc aatcgccccg ctggctttat gattcagcac cgcataacaa 2198161 ggaaggtagg cgtggtcaga gccgatatcg gccatcaccg ctccattcgg tatgtactcc 2198221 gctactgttt gcaatcgttt agataatttt aattcgttca cttgtcatca caacttttct 2198281 caatcatttt ttcctttact atcatataaa aaatcagccc ggaatccaag ctgaagcaaa 2198341 tgattttgaa attatttctt ttgatgcggg tctgcacgca gcagtcaaaa ataaaaggct 2198401 gtcgagaaca tctcggcggc ctgtgaatgt ataaagagaa aaatagttct tttatttaat 2198461 ttttgacacc cactctgcca tatcatccag cttatcggcc ggaacaagac cggaaggcat 2198521 tccattaccg cctttttcga tctttgtttt aatttcagcg acatctttct tatcccctac 2198581 accttttaag ctaggacccg aaacaccttc ataattttca ccgtggcatg cgatgcagtt 2198641 tgccttgtaa atttcttctg gtgaagcgtt tgcatctttc ttttcagcag atttgctttc 2198701 tcctccgctc gcaatctccc gagagtcatc aagtcctttt actgataaaa agaaagttag 2198761 accaattcct aaaacagcga tcagcaaaaa tggaataagc gggttccatt tcatttccct 2198821 tccccctttt tgatccttcc ccctatgtaa acacttctaa ttctaactta tttttacaaa 2198881 aagtaaatgg attgctatac aaaagttttt tattcacact ttatacaaaa ttgaatagaa 2198941 acatgcctaa atctctaata tcctttttat tctattgtat aatgtattgt atacgcttac 2199001 aatagaaaat atggaattag attttgaaat ttttcaccac aatgttcatt tgcaaatgac 2199061 atcatttttc agtaaaataa aggcatatta tccatatatc tttttaaaaa aagaagaacg 2199121 gatcttcaag acccgttcca tcttattcaa ggaaatcttt caaacgttta cttctgctag 2199181 gatgtcttag tttccgcaac gctttggctt cgatttgtcg aatacgctct ctcgttactc 2199241 caaatacttt gccgacctct tctaatgttc ttgtacggcc gtcatcaaga ccgaatcgaa 2199301 gacgcaatac attttcttca cgatcagtta acgtatcaag cacatcttcc agctgctctt 2199361 tcaatagctc gtatgcggcg tggtcagaag gtgaagttgc ttcttggtct tcaatgaaat 2199421 caccaaggtg cgagtcatcc tcttcaccga tcggtgtttc cagagatacc ggctcttgag 2199481 caatctttaa gatttcgcgt actttttcag gcgttaaatc catatcttcc gcaatttctt 2199541 caggtgttgg ttctctgcct aagtcttgca gtaattgacg ctgcacacgg attaatttat 2199601 taatggtttc aaccatatga acgggaatcc ggatcgttct cgcctgatcg gcaatggcgc 2199661 gtgtaatcgc ctgtctgatc caccacgtag catacgtact gaatttataa cctttgcgat 2199721 aatcaaattt ttcaacggct ttcatcaggc ccatgtttcc ttcctggatc agatcaagga 2199781 acagcatacc gcgtccgaca taccgttttg cgatactgac aacaagccgc aggttcgctt 2199841 cagccaatct gcgtttagat tcttcgtcac cttcttcaat cttttgagcg taggcgattt 2199901 cttcttttgc agaaagaagg ttaacccgac cgatttcctt taaatacata cgaactgggt 2199961 cattgatttt aacgccaggc ggtacactta ggtcattaag gtcaaattct tcttcggctt 2200021 tggcaagctg ctgaatatta ggatcttctg tttcttcatt ctcactaatt aattcaacac 2200081 cttgttcacc taaaaattca taatactcat ccatttggtc tgattcaatt tcaaagctgg 2200141 acatacgctc agcaatttct tcatatgtca aaacgccacg ttttttacca gactctgtta 2200201 attgctcttt tacttggtcg aatgttaatt ctgtctcgtg ggtttgttta tcagccatta 2200261 tggatccctc cttccaaagc ttgcaacgaa ttctataagc ggtatgattc ttattcggtc 2200321 cattcaggcg ttttctatgt gaactgcctt taacaatgtg cgaataatga aatgacaatt 2200381 catgatgagg ttaagcgatc tatttgctcc tccgcaagga atcattgcca ataaatgctc 2200441 ctcatcagtt ctccagttat tttaaagatc ggttcaatgt aacgatttct tgagccaaag 2200501 aagcagctct taaaaaatct ttttgccttt ctgcttcggc tctttccgcc tctttttctt 2200561 ttatcattga ccaatttctt tgattcaaca ctttttttac ataatctgat aactcggctt 2200621 cgctaagctc ttgattaacc tgaagcatta atatatcgga caagagctgg cttatatgat 2200681 catccgtcac cctggccatc agatgctgag gcgtcagctc ggctccctct tcataaaaag 2200741 cataaagata agcggctaat gcccggtgct catcaatatt aaattgaaac cctacccggt 2200801 caatcacttt tttgatgacg ctccgatctc gaagcatgtg agcgagtaac agcctttctg 2200861 cattttcata cgccggacgc aaacgttttt gccttgcttt tgtcgtcaga tgcgctcgcc 2200921 gcgttttagt ttcaccgcta ttgtcagcag gtttgttttg cttgctgaaa acagacagct 2200981 gctcagttaa agactcctgt gaaagcgaaa actctgaagc aagctgcttt acatagactt 2201041 cctgctctag agaccctgaa agcgtgctga tttctttcag tacgtcttta atgtaagcta 2201101 ggcggtcgcc ttcatcggac aggttctttc cttttcggaa atattgcatt ttgaacgcca 2201161 ttacggtgac acttgcgtca ataatgtcgt ttttaaattt ttccccgccg aattttttga 2201221 tgtaatcatc agggtccaat ccgtcaggaa tcattgcaac tctgactttg cagccttttt 2201281 tttgcagaag ctccgaagct tttaaggtgg cttcataacc ggctttatca gagtcatagc 2201341 aaagaatgat ttcttcgacg tttcttctca ggatcttgac atgatcatct gtaagagacg 2201401 ttcccatcgt ggctatgctt tcctttacat ccgagcttac ggccgatatg acatcagcaa 2201461 acccttcaaa taagactgct ctttcctgct ttctgatatg aaggcgggcc ttataaaaat 2201521 tgtaaagcag tttgctttta tgaaagagcg gggtttcagg actgttcata tacttaggct 2201581 gctggctgcc aagagccctg cctgagaaag caacaacagc cccgtgatga tcatggatcg 2201641 gaaacatgac acggtttctg aagcggtcga aatatccgct tccgtcttcg cgtctgatca 2201701 ggagacccgc tttttccatt tgcgcctcac taaatcccct ctttacaagg aatttcgtga 2201761 taaagtccca agaatcaaga gcatagccaa tctgaaattc attaatcagc tctttcgtaa 2201821 agcccctaga aagcagataa tccagtgcct cttgaccttc ttttgtattt attaacaaat 2201881 gatggtaaaa tttcttcagg agctcatgtg cctcagccat tttttgttct ccagaagact 2201941 ctggccgggc tccggaatgg actgttatat catctggaaa atcaatttgg tatttgtcag 2202001 caaggtgaga aaccgactcg gcaaaagaat agccttccat ctgccttaaa aaagagaaaa 2202061 cattgccgcc cgctccgcag ccaaagcaat gaaaaatctg tttgtcgggc gatacggaaa 2202121 acgaaggtgt gctttctcca tgaaaaggac agagtccaaa gtagtttcgg ccttgcttct 2202181 ttaattgaac ataatcacct atgacttcaa cgatatctgc cgacttttgc acctgatcca 2202241 caatttcatc tggtatccga tttcccatct tataacactc cgtcgtacat tattcgatgc 2202301 tttagtgcaa aatcccttca tcgttcgaca ggattttttg cagcagtgta ataaatcgtt 2202361 ctcgatcttc tttattcaat tttttaggcc ctttggcata tacgcctttt cttctttgtt 2202421 tgccggaaaa atgacggccc tctagggcaa aatcaatcgt gtcttccttg taaagacgac 2202481 ctctttccga cataacagag acatttctgt tcaacagcag agatgctaat ccgatgtcct 2202541 gcgtcacaac aatatctccc ggtttcacgt gatttgcgat atataaatca gcagcttctt 2202601 tatgaggatc aacatacttc catttttctt cattgcttct ggaaagctga taatgttcaa 2202661 atgaagcgac aaaaagaact tgaacttcat actcggatgc tgtttgtaaa atttcatctt 2202721 ttaccggaca agcatcagca tcgacaaaaa tcgtcttttc ttgttcatta agaagagtaa 2202781 ttctccatcc ctccattaaa ctcctgcata aaagcaagca aaatcgcaca tcctttatta 2202841 ttgtggatgt atatgaattt gtcgaaaaat ttccgggaga aattcttgac atcttaccca 2202901 taatagttta ttcgtatcac acgatcctta aacctaaaat taatcatttt atcacaattt 2202961 tttattataa tacaaacttc acaaagatgc tattgttttt cattattccc ttttggcaca 2203021 gccaaaaacc caggatagag cgtcctgagt tatatgtttt ttgttttgag atgatggata 2203081 atatttgctg tttcctcaac cgctttattt gaaacatcaa caacctggca gccgatccga 2203141 tccacaatct tttcgaaata ctcgagttcc tctttgattc tgttgatatt tgcataaatc 2203201 gctttatcat taagcccgag tgattttaaa cgttcttttc tgatatgatt cagtttatca 2203261 gggctaatct ttaaaccgat gcattttttc ggatcaacgt taaagagttc ttccggcgga 2203321 tcaacctccg gtacaatcgg aacattggca accttcaggc gtttgtgtgc gagatattga 2203381 gacagcggtg ttttagacgt tcttgacacg ccgatcaaaa cgatatcagc ttttaaaatc 2203441 cctcttggat cacgtccatc atcgtattta actgcaaact cgatggcctc cacttttttg 2203501 aaataatctt catcaagctg gcgcacccgc cccggttcgt atttcgctgt taaaccgtag 2203561 gctgtttcca ttttatcaat caacgggccg ataatatcat aatataaaac atttgctttt 2203621 tccgcttcgg ctatcaaata ttctctgatt tccggcacca cgagtgtaaa acagataatg 2203681 ccgccgtctg cctttgcaag tgaaatcact tcattgatag tgcctatatc ttcaacataa 2203741 ggaattcttc ttacatgagt atcatccgcc gatccgttaa attggctgag tgctgctttt 2203801 actaccaatt cagccgtttc accgacggaa tccgatacaa catagatgat gcggttattc 2203861 atattatccc cccgttagtt tgcaatctta taggatttca ttttcagata aactgacaag 2203921 tattttggtc atatttgttt ttgtcactct gccgatcact tcaaagcctt tatcggtgtc 2203981 tttgatgaca ggcagtgcat caatttgttt ttctattaag tgctttgcaa tgtccatcac 2204041 ataatcctcg cgtctgcaca ccgtaatgtt cggcatcctt gtcatgatga tgtgaacagg 2204101 gaccgatgta agctcctgct ggccaatgct cgctctgagc aagtcttttc gtgaaagcac 2204161 cccgactaaa acagcatcgc ggtccaccac aaacagagta cctacatctt ctaaaaacat 2204221 ggtgcaaatc gcatcgtaca cagaaacgtt ttcgtgaatc actacgggga tagattgaaa 2204281 gtctttcacc tgaagctttt tgagtttatc cgccaaaagc tgtgtgccgg tttttcccgt 2204341 atagaaataa ccgactctcg ggcgcgcctc gaggaatcct gacatggtga gtatggctaa 2204401 atccgggcgc aatgtcgccc tggttaggtt cagcttttct gcaatatgct cccctgtaat 2204461 cggcccgttt tcttttacaa tctgcaaaat atgttcttgc cgtttattta gttcgatcgt 2204521 actcaccacc ttttcacttc atagctatgt aaagaaataa caatccatat tataacgtaa 2204581 atatcttgta atcaaacaaa aaacttataa atggggaaaa gacgattacc gatcacacag 2204641 caaccgcctt ttctctcttt attttacaat aagggcattc atattcgcaa aggacttgat 2204701 ctcatccgcc aagcttacca tttgcgctaa acgatttgcc tttaatgact cattatccgc 2204761 tataaccatt gtatgatcga agtaagcatc gatcggttct tttaaggctg caagtgaagc 2204821 aagcgccgcc tcataatctt ttttgctgaa gttttcctgc agattttgct tcgctgtttg 2204881 gtaggcatca aacagttttg cttcgtattc attttcaaac agatcaggct gaatgtctcc 2204941 gcggactcct tttttgctga tagagatcac tcggcctaac gcttcggctg tttccttaaa 2205001 gccaggtgca ccaagctttt gctccagtac ttgtgcttta tgcagcgcag agtacggctc 2205061 aagctcagag ctttccagca cggcgtcaat gacatcatgt ctgatttgtt cagcattcaa 2205121 gacatatttc aagcgctgag tgaagaaatc cagcagttca ttttctttat cggtttgaac 2205181 gaaagtaagc agctcttcaa atgaaattcc ccagttgcgg tcaagaagaa tcgcaacaat 2205241 accgcttgct tggcggcgca gtccgtaagg gtcctgggaa ccggtcggaa ttacgccgat 2205301 agagaagaat gaagcgattg tgtcaagctt atccgccatt gctacaacag ctccggtgaa 2205361 agtagaaggc gtttctccgc ccgctgatct aggcatataa tgttcattaa ctgccgcagc 2205421 cacagcttca tcttcgccaa gcattctcgc atacttttcg cccataattc cttgaagttc 2205481 agggaattca tatatcatat gcgtcacaag gtcgaattta gaaatttcag cagcccgctt 2205541 cacatgtttt aatgtatctt catcagcctg aagacgaacg gcaagtttct ctgcgattga 2205601 tgtgactctc ctaaccttat cagcaagaga accaagctct tcatggaaaa cgatattttc 2205661 aagcttcttc acatttgcat caatgtttag tttctgatct tctttgtaga agaatgaagc 2205721 atcagataaa cgtgcgcgca gcactttttc attgcctcgg gccacatttt caatcgcgtg 2205781 gctgttgccg tttcggactg tgataaagtg aggcagcagg tcaccgtttt tgtctttgac 2205841 agggaagtag cgctgatgct ctttcattgt cgtgacaagc acttcttcag gaattgacag 2205901 aaactcggat tcaaatgaac cgtaaagagc tgtcgggtat tctactaaat gattcacttc 2205961 atcaagaagg tcttcgtcaa ctggaatgct ccaattgttt tcagcagcca ttgtttccag 2206021 ctgagattga atcatttgct ttcggacgct aggatcagca ataacatgct gtcctttgag 2206081 ctgctcttca taagctgaag gtgattcaat tgacacttca tgtccgagga aacggtgtcc 2206141 ctgtgttgtc cgtccagact caacgtttgt gatcgaaaat ggaatgacat cctgtccaaa 2206201 taatgcgaca atccatttga tcggtcggat ataacgcaaa tcttcatttc cccagcgcat 2206261 gtttttcggg aaatgcaagc ttgtaattaa accgctcaat tctggcagaa gcgacttcgt 2206321 ttcttggccg gcttggaatt tttgcacgaa tacatactct atgcctttta cttctttgat 2206381 gtacaggtct tccacatttg cgccttggcc ttttgaaaag ccgattgccg cttttgtcca 2206441 gttcccgtcc gcatcaaggg caattttttt cgcaggccct tttgcttctt cttttatatc 2206501 atcctgcttt tctgcgacat ccttaacgaa cacagcaaga cgtctcggtg tattgaagag 2206561 tttcacttca ccgtgagtaa tatttttttc tttaagccag cctgtcagct tgtcgccaag 2206621 ctgaaccatg ctttcattca aaaagcgcgc cggcatttcc tctaatccga tctctaaaag 2206681 taaatcctgt ttactcatga gaagaaccct cccctttaag cattgggaac cctagttttt 2206741 ctcgttcctc atagtaggtt tttgctactt ttctagctaa attccgcact cttgcgatat 2206801 agcccgtccg ctcggtaaca gagatcgcac ctttggcatc aagcaggttg aaagtgtgcg 2206861 agcatttcag cacatagtca tatgctggat gaacaagtcc gttgtccatt tgcttgatcg 2206921 cttctttttc atatgtgctg aacaattgga acagcatatc gacgtctgat gtttcaaacg 2206981 tataaacaga atgctcatat tcagccatca tgaataaatc ttttactgta aaccctgacg 2207041 tccattccaa gtcaaacacg ttttctttat cctggatata agacgcgaga cgctcaattc 2207101 catacgtaat ctctacagaa acgggtttac actctaatcc cccgacctgc tggaaatacg 2207161 taaattgtgt tatttccatt ccgtcaagcc aaacttccca gcctagaccc gcgcagccta 2207221 aagacggatt ctcccagttg tcttcaacaa agcgaatatc gtgctcaagc ggatcaattc 2207281 caagagcacg caaggaatcc aaatacagct cttgaatgtt atcaggtgac ggtttaataa 2207341 tgacctggaa ctgatgatgc tgatacagtc tgttcgggtt ctccccgtag cggccgtctg 2207401 ccggacgtct ggaaggctct acataagcca ctttccacgg ctcaggaccg atactgcgca 2207461 aaaatgtata cgggctcatc gtgccggctc ctttttctac atcgtaagcc tgcataagca 2207521 cacagccctg actggaccaa tgcttttgca aggttagaat catgtcttga atattcattt 2207581 caagcacctc cacttttctt tcataagttg actgcggcag caaccaaaaa actcccgtct 2207641 ctatgcttgc cagccgcaaa catagggacg agagttctcc cgcggttcca ccctagttgc 2207701 tgagaacaaa atcccagcct cttttttaaa attgctcaag aatgcctttc gttgcgtgct 2207761 catccttagc ttacaccgcc ctaaggtcgc tttcatgagg taaacgcaag tacttctttc 2207821 tctcactgca acatatttta taataaatga tcatataaaa agatggacca aatgtcaact 2207881 tttgttttca cccataagat gtttcatgct ttccatttga tctaaaaagc gctttgattt 2207941 taaatacaat cccgaatatt cttcgtaata taaatcaatc acttgcttta attcagcttt 2208001 tgtttcctct tttaaggaca cattgccgag tctcgacaga tcaaaatagt aaaagagcct 2208061 taacagcctt gccgtttgcg gtttaatcgg tatcctgtaa ggatcttttt caaaacagcg 2208121 gtggcatata aaaccattat cacgaacaga gaaatgaaag gttccgtctt ggcttttaca 2208181 atgtacacaa tgattcagct caggatacag gcccatgaca ccgagcatct tcatttgaac 2208241 aatgaaggtg ataacatccg gatctgttcc ttcattcaac tgttttaatg attctaatat 2208301 gaattcaaat aaataaggat ttggcttttt ttcttctgtg cctctgtcga ctaactcagc 2208361 aacataggca gcatatgctg ttaaaaacaa gtcttccctg atgcctctca tgctgaggat 2208421 catttccccc tgctgaagcg ttccgaggcc cgatgttttt tgcattaaga aagaaccata 2208481 caaaaagggc tggctgactg ctgataaacg gctgttcggt tttttggcgc ctcgtgccat 2208541 aacacctatt tttccgtgtt ctcttgtcag taatgttacg attttattcg tctctccgta 2208601 atcatttgtg cgaagaacga tcccttcaca ttttgtcagc atttccgcac cttcctcaag 2208661 caggagcggc caagaggttt ataaaattgg ataatcaaat cgggctagct catcttctag 2208721 ttcttcgggt ctttccatgt tctctttttc cagttcttta aaaagaagat acgtatcaac 2208781 atttcctgtt tgagaaaata cgttccaggt aaaattcaac acaagaaacc cacctttctg 2208841 tagttaaact agcttaccta aactccaaat tcttaccttt atcttgacca gatgtcctcc 2208901 atttcatgtt aaacaaaatt tgctaatgta tccctgttcc tgtgagataa tgacacacac 2208961 gggaagagat taatattcgt cctctttaaa gccaaaatcg cgaagctggg acattttatt 2209021 acgccagtct ttctgcactt tcacccacaa ttcaaggtag acacgggagc ccaacagtgc 2209081 ttcaatatcc gctctcgctc tttttccaac ctcttttaga aggcttcctt ttttaccgat 2209141 cacgatgcct ttctgggaat cccgctcgac cacaatcgtt gccgctacgt gcacagaacc 2209201 gttgtcctgc cctttgatgg attcgatggc caccgcaatg ctgtgcggga tttcttctct 2209261 cgtcaaatgc agcacctttt ccctgattaa ttcagaaatg ataaatcgtt cagggtggtc 2209321 agttacctgg tcactcggat agaattgcgg cccttccggc aaatacgctt cgatctgcgc 2209381 gagcaaggtt tcgatgttat ttccttctaa agcagaaatc ggaacaattt ccttaaaagg 2209441 ataacgtttg cggtattcgt caattagcag aagcaattgg tcgggatgaa ttttatcaat 2209501 tttgtttacg attaagaata caggcgtaga catcgtctgc aatttctcaa tgatgaattc 2209561 gtcgcccttc ccgtagcctt cctcagcatt gatcataaac aagatcaaat cgacttcttt 2209621 taatgtattt tgcgccactt tcatcataaa gtccccaagt ttatgcttag gtttatgaat 2209681 ccctggtgtg tcaataaaaa tggtttgtga tgtgcctgtc gtcagtactc cttgcacctt 2209741 gtttctcgtc gtttggggct tatcgctcat gatcgcgatt ttttgtccaa tgactctgtt 2209801 caaaaatgta gattttccta cgtttggtct tccaataatg gatacaaatc ctgatttaaa 2209861 gctttcgttc gtcatgtaaa tcctccgatg aaaatgcgcc tggcaataat tcttccacag 2209921 tcatttcttt tatttgtcct tgtaaattag tcagtacgac aataacgtct tttgtgcaaa 2209981 gctcagaaat cacctgtcgg caggctccgc acggagatac tggtccaggg gtgtcagccg 2210041 caacggccag catctgaaac tctgtatccc cttcagaaac agctttaaat aaagcggtac 2210101 gctcggcgca attgcacatg ctgtatgccg cgttctcaat attgcagcct ctgtacactt 2210161 ttccatcctt ggtaagaaga gcggctccta cttggaattt ggaatacggc gcatatgcca 2210221 tatcacgcgc ttttaaagct tctgttatta attcttgtct gttcatgtgt acattcctct 2210281 cttacctata atggtaccgc tatcacttta tattttacat aatcgcgcgc tttttttcac 2210341 gcccatttct aaaaatgtaa aataaatgta agaattttca gccattacag ctttggcaaa 2210401 aaaataagta aaccaatgat acacgaaatc acggcaaaaa cgcaaacagc cccggcggca 2210461 gcgtccttgg ccgctttagc aagagggtga tgtttgtcag ttattaaatc aaccgtatgt 2210521 tcaatggctg tatttaaaag ttcaagcgaa aacataccac ctatcaaaag gaatataatc 2210581 atccactcaa taatgctgag ctctacaagg aagccgcaaa tgagaacagc gcaggcggct 2210641 gcggcatgaa attggaaatt ccgctccgtc cgcgctgttt cccatatgcc ccggcctgca 2210701 tgcacgaagc ttttgaagaa tcgattcagc tcatttctat gatcttttga gtccataagc 2210761 gtccagcaat tccttttgct tagtaaacat ctcctcttct tcctctttcg tcatatggtc 2210821 atatcctaaa aggtgcagaa atccgtgtac agctagaaat ccgagctctc ttttaaaaga 2210881 atgattatac tcctctgcct gctctcttgt gcgatcggca ctgatgataa tatcacctaa 2210941 aaccggaggc atttcggcgc ccacgatttc gatctcgcct tctccctctt cttcaagagc 2211001 aaatgagatg acatctgtcg gagcatcctt tccccggtat tctttgttaa tctgatgtat 2211061 gtcatcattg gaaacaatcg tgacagaaac ttcagcctga tcctgaacgc cttcacgctc 2211121 agcggcaaat tgaagcagat tttctacttc tttgagcatc tcttctgaga cgcttcccgt 2211181 ttcatcaacg atatcaatca gtaaactcat ctatttcacc ttcttagtag cctccggata 2211241 ttcaatccgg gagtggaaaa ttccttttaa tgttgcacag agcgtttttg cgattgtatc 2211301 cagctcttta aatgtcaaat cgcattcact gaactgtccg tcctgaagct tatcggatat 2211361 aataccccgg acaagctttt caattcgttc aggatttgga ttgtgcatgg atctgacggc 2211421 cgcttcaaca ctgtcggcca ctgatataat tgcggcttcc tttgactgcg gcttcggtcc 2211481 cggataacgg aactcttcct ctgtaatctg gtcgcctttt tccttcgctt tatagtaaaa 2211541 aaactttaaa agcgaggttc catgatgctg ctcagcaata tcgacaagct ctttcggaaa 2211601 tttatagctt ctcagcatat tcgcaccgtc tgtcgtatgc gagataataa tatttttgct 2211661 caactgaggt gacagcttgt catgcggatt gtcaatattc atttggtttt caataaaata 2211721 ttgcgggcgc tttgtttttc cgagatcgtg ataatatgcg ccgactcttg caagcaaacc 2211781 attagcccca accgcttcac aggctgcctc tgataaattg gcaaccatta cactgtgatg 2211841 atatgtacct ggtgtttccg tcagtatttt gcgcaatagc ggatggttag gattagacag 2211901 ctcgagcagc ctcatggtgg ataaaatgcc aaagcccgtc tcaaaaaacg gcatcagacc 2211961 gatgatcaat acagatgaag caaaccccga cacaaccccc atgagcatta acgtgccgat 2212021 ttcaagaccc gacagcgcag tgttctggat caataataag gatagaacga caaccatatt 2212081 aataaacgcc acgaaaagtc cggtctgcaa aatctttgat cttgcattgt gttttcctaa 2212141 aaataataca cctgaaatgc cgctgatcaa ataataaatc cctatgacat aattgaatgt 2212201 tcctgtcaca ccctgattaa acatcatact tccgcaaatc gcaagaatga tacttcccaa 2212261 aatggcaatg cgttcattca tcagcagttt gattaagatg gcgccggccg caatggggac 2212321 cagatagccg atattattat actccatctt ctgaaacaaa ctgacaacct ccatgatcac 2212381 aagcaaaagt gttgtgatta tggagaataa cagaatggat tggtttttaa acttcagatt 2212441 ttgtttctgt ttttcaaaat aatatacaag tgttgcaatg aaaagtccga tcataatcaa 2212501 tagcccgctg atcggtttaa agagatttga gttatttaat aacccggtca gctcaagttt 2212561 cctgtacact tcccgatcaa tgaggtcatt ttcttccacg agcacttgcc cctgtttgat 2212621 ttgaacctgc tggacattat ctgaggcttc ctgccgtttt gcctctgttg ctttcggatc 2212681 gaagacgtaa ttcggaataa tagcaaaacg cccgatttct gtcgcggctc ccaagtattt 2212741 agacggaata gaattgctct ttagctcttt ttctacctta tcctttgcat cagatagttt 2212801 atccgaaggg atttcactgc tcatgaccgt atttaccgcg gtaatgaccg tatctctgac 2212861 aaaagaaaag tcttcactgt ctgctttcag caatgtcttg atggaatcct ccgatataga 2212921 atcattcaca tctgatgtca atttgtcctt tacagatttg accattgatt tttccgatgg 2212981 tgatttactg ccttcttccg atgatttttt cacttcacta atactgtcga atattgatga 2213041 cacaaggtca atccgattgt ctgtatattc tttttttaat gtatattgat cttcaaccgc 2213101 gtcctcagcg gcttgctttt tttcctctgt ggctttttga tcttctacgg ttgccggagc 2213161 gtaaatggtc ttgtcgctga ctgaaaacag gtctaaatca agtgtttccg gcttaacatg 2213221 tacaaagagc aaagcaaaca taatggcagc cagcagaaga tacagcagta catgcatgga 2213281 gcgggcattt ttaaaactgc tccatttttt tgagctgctt ttggtcttag ccttcttttt 2213341 caacacaaga acctcctctt gaaacatcaa gcccataagc aatcataaaa atgacccgat 2213401 aacgcgcgat cgggtcattc agcattaatt ttgcttatcg tatgcttcaa taattttcgc 2213461 aacaagcgga tgtctgacca cgtctgtctg gtctagctca atcatagaaa tgccgtctat 2213521 tcctttcagc atctccttcg ctactgcaag tcccgatttg acgcctttcg gcagatcaat 2213581 ttggctaacg tcacctgtaa tgatcatttt agagccaaaa cccagtctcg tcaaaaacat 2213641 tttcatttga gcaggcgtgg tattctgtgc ttcatcaagt ataacataag catcatcgag 2213701 cgtccgtccc ctcatatatg cgagcggagc aatttcaatg atgcctcttt ccatcagacg 2213761 ttctgtatga tctgccccaa gcacatcatg gagagcgtca tacagcgggc gcaaataagg 2213821 atctactttt tcttttaggt cacctgggag aaaaccaagg ctttcaccgg cttccacggc 2213881 aggtcttgtt aaaatgattt ttttgatatg tccgtttttt aaagcatgga ctgcttttac 2213941 gacagccagg tacgttttcc cggttcccgc cggaccaatg ccgaatacaa ggtcattccg 2214001 cttcatagcg gccacgtatt cccgctgtcc cattgttttt acacggattg atttgccttt 2214061 tgcgtttttt gtaatttctt cttcatacat gctttcaaag tattcaagtt cattcttctt 2214121 tgccattttg atggcgtaaa tcacatcacg ttcagagatc tctatcccct tgcgaattaa 2214181 agcgaggagc gatcccagca gcctgtctgc aatctgaaac gattcatcat cgcctgaaac 2214241 ataaatcgtc tcgccgcgcg taatgatatt taaattcaga tctttctcca tcaatttcaa 2214301 aaaagaatct tggttcccga agagtgaaag cgcctcgtcc gggtttttca gtttttgatt 2214361 catcgcaagt aaatgttctg tcattcttca gtctccctga caataggtgt ggtttgaacg 2214421 atatcttcta taacttggta gagaataatc aactttactt taccattctc aacagtctgg 2214481 tgcaaaactt tttcactttt cacctcgccg ttttcgccta ttttatcctc tacatcctgt 2214541 ttacccaatt taatgccttc ttgaactgct tcttcttttg tatattttcg caaagcctct 2214601 tcactttctc tcgtttgctc tttgacatag gatacaggga gcttaaatcc gagaaaatga 2214661 agcgaatgct tttcttgttc tgtttttgga tgcttcaatt cctctttttt aaacgtcatc 2214721 ccccagatcg ggattgccaa agaaccaaaa gaaagcttgt gctttgtcct tactttgccc 2214781 gtatagacgt taaataatgt ttcaagcggg actgtcactt ctgatctata ccaggtttct 2214841 ccataaattt ctgcttttga ggcgacttcc tgctgatggt cttcgctgcc gatcagtccc 2214901 gaaacaagca gctgtccctt ttcaacatga tcgtgtatgg cggccatggg ctgtcctttt 2214961 tgcacaaaca ttctcgtaat ggttgctttc tttttggcga caatattgcg cgggctaaca 2215021 tatttttctt tttcgggctc atttttctcc acaactttca tatgaatggt cgtccccttc 2215081 agatcaactc cgacccaagt gatattgtct attccattgg ttaatgattt ctgtattttt 2215141 tcgggcgaca tcattaaaaa ctgcagacgg ccctttttga cgccgatttc attaagatgc 2215201 tgcctcattt gatgttctgt ttcaggctta gcgcctgtca catcaatttt ccacaccata 2215261 ttggacagca aaaacaaaag aatgaaaaaa atcgcaaaac cgatcgtaaa ccctatattc 2215321 agctttgatt tcagcaacag gaagggaaat cccttccgat tgataaatcg ggctttacat 2215381 ttaaatttac ttcttacccg ccgaaaggca tgtacatcct gaagctgtat atataacgat 2215441 acggcttctt tctttttttt gacatgaaag accggaatcc cctgtcttgt gcattcatta 2215501 aggagccgct caatccctct tcccgtcaat tcaagctgga ccttacccga aaaaaaagac 2215561 agccatttat ttttcacaac atttccccct cggctttatg actcaacata tcgaacgaca 2215621 tcaatcgtac cctccaaaag tatctcttcc ggaagaatcg ccttgatgac aaaattttta 2215681 ccagatatga tgcactggcc ctgcttcagc atcagccgca cttcattctc actgaaaagc 2215741 aaaaggcctc tgtggttttc tatgtagata tgaagtctgc caaccattgt aatcctcggc 2215801 agatccatca taacgtccgg gggaatttcc aatgctcttg tcagccaagc tttcatacga 2215861 ttctttcttt gccccataca aaaagaaccc cctttcatct catatgtatg atttgaaagg 2215921 aggttctaac actttaattt ttacgggccg ggcgcatcgt acggtgaggt tttttcgccc 2215981 gtggaggtcc gaacacctct cctagaacga tcccctgtac gacggtgtct ttattcacct 2216041 gaagcatttt ttgttttgtg tatactgttt tttgtttggc agcagcaaga tctcgttcca 2216101 gccctttcag gtttcttgct gtttccctgc gtctttcttc cgcttcccgt cttgcctgtt 2216161 ccatacggtt agggataggt gcaggggcat cttcttttga ctgcttcttt tgaggagaag 2216221 cagattgcac gtgttgaggt ttttttcttt tttggctgtt ttgcttttct tctttgctct 2216281 ttttgccgaa aatcgcagaa atgattccga tgatcgctgc aataataagc ggattggtca 2216341 gtaaatcttc catcagcgtt ctcccttctt agagagatta tgatttgcgg tcttcatccg 2216401 aagggtcttt cgtcagcttg ccgaatgaat cacgcatttc tgtgtcagca tcgatgttct 2216461 tgatattcat gtaatccatg acgccaatat tcccttcacg caaagcttct gccatcgcaa 2216521 gcggcacttc cgcctcggct tctactactt tcgcgcgcat ttcttctacg cgggcacgca 2216581 tttcctgttc ttgagcgaca gccatcgcac gtcgttcttc cgcttttgcc tgcgcgatgt 2216641 ttttatcagc ctcggcctga tcggtttgta aaattgcccc gatgtttttg ccgatatcta 2216701 catctgcaat atcaattgag agaatttcaa acgcagttcc tgagtccaat ccttttccaa 2216761 ggactgtctg agaaatcatg tcagggtttt caagcacttt tttatgatta tcagatgaac 2216821 cgattgtaga aacgattccc tcacctacac gagctacaat ggtttcttcc cctgctcccc 2216881 cgacgaggcg ctcgatattc gctcttactg tgattctcgc tttcgctttc acttcaatcc 2216941 cgtccattgc gacgccggca atgaacggtg tttcaatcac cttaggatta acgctcattt 2217001 gaacagcttc caacacgtcc cggcctgcaa gatcaatggc agcacagcgc tcgaatgtga 2217061 gttcaatgtt agctcgctga gcggcgataa gcgcgttgac gactctgtca acattacctc 2217121 cagccagata gtggctttca agctggtttg ttccaacatt aagtcccgct ttatgcgctt 2217181 taatcagcgg gttaacaacc cgattcggaa tgacgcggcg aagcctcatc ccaactagag 2217241 tgaaaatgct gattttcact ccggctgcca aagctgaaat ccaaagcatt acaggcacaa 2217301 atgtaaaaaa tactgccaaa acaatgatcg ctactgcgac aattgccaga atcataagtg 2217361 ttgacggatc catataactt ctcctcgttt ctatttaaat ttctctcacg acaatgcgtg 2217421 agccttctac ttttatcact tttacttttt tatctttttc tgtaaacgat ccctccgata 2217481 caacgtcaag gcgttcatca tcaataatca cggtaccgga aggacgcagc ggtgtaaagg 2217541 ttatacccac ttttcccatt aagtccgtgc gcgtttgatt tgaaacgtag ccgctctccg 2217601 tgtttgtaga atcatttaat atcaatttct taaagaattt catacgcttt cccaacaccc 2217661 ttgtcagtaa aataaaagct gtaatcgaaa cagctgaggc gatcaagaga gaaaccgcca 2217721 tgacagtgaa gctccccgcg gctaaaaaca ggctcgcaat aatcgctccc aagcccagta 2217781 atccaatgat tcctccggga agaaaaatct caagcagaat gagaatcacc cctgctataa 2217841 agaggagaac cgtctcatac ccggcaaggc cggctgcaag atgcccgtaa aagaacagca 2217901 ataacgcaat gagtccagcc gttccaggga ggccgacacc cggggaaaaa agctctaccg 2217961 tcagacctaa aaaagcgatt gtcagcagaa tagggacaat gaccggattc gtcagccatc 2218021 ttgccgtctt ttccgcaaag ctctcctttg catagctgat ctgcgccttt tcgaacccaa 2218081 gcttctttac gagcgtggac aaattgtcag cagtgccttc tgaatagcct acctcaatcg 2218141 ccttgtctgc gttaagtgtc agcagatctc ccttaggcgc gccaacttcc ttggcatcta 2218201 tatctgggtc agccattgcg agcgcatatt ttggatcgcg gttatttttc actgcggcat 2218261 cttccatctc tgccagccaa agtgattgag ctttttggtc agcggcattg ccttggccat 2218321 caacaatcgc ggcggctccc atttttccgc caggcgccat ataaatgtga tctgcttgaa 2218381 gtgcaatata tgcaccagca gacaacgcgc gtttgttgac atatgcagtt acggggatct 2218441 cgctttcggt tatcaaatcg gccatatcaa tagcagattt gaccaatccc cccggggtat 2218501 tgatatcaag aataatatgg tctgcatgtg catcctttgc gtcttgtaac gaacgggaca 2218561 aaaacgaggc gagaccctgt tcgacatttt tttcaaccgg gatcacataa acagtttgtt 2218621 tttctgcttt tgcgttcagc tgtacgccta ataaagaaag taaaaatata cccaaaagag 2218681 cagcacggaa tcctttgatt tgaagcaagg gcggtgtatc cctccttcct tttataataa 2218741 gtgccttctc ttcatacgta acaaatgtat caaaggtttc atttttttat gtataaaaaa 2218801 agacatctct cttagaaaga tgtccttttc tttgccattt aagacagttg actgctcaca 2218861 agcttattaa ttaaacttcc gtcagcttta ccttttactt taggcataat tgcccccatc 2218921 actttgccca tgtccgcttt tgagctcgca ccgacctccg cgatggtttc atttacgatt 2218981 gtacgcagct cttcttctga cagctgctca ggtaaataaa cttctaaaat gtccagctct 2219041 ttttgaactt tatctactaa atctaaacga ttagcgtttg aaaattcctg gagggagtct 2219101 ttacgttgct taagttcacg agaaaggaca gtgagttcct catcctcggt caaactgtct 2219161 ttcttaagct taattgcttc attttgaagt gaagccttaa ccattcgaac gacagtcagt 2219221 ttgtctttct cacggttttt catatacagc ttcatatcct ggttgagacg ctcaagaaga 2219281 ctcataaatc caccctcttt tagaatttgc gttttctagc agcttcagac tttttcttgc 2219341 gctttacgct aggtttttca taaaattcac gctttcttgc ttcttgcaaa gtacctgtct 2219401 ttgatacact gcgtttgaag cgacgaagag catcttcaag cgattcgttt tttctaacga 2219461 ccgtttttga cattctcttt ccctccctcc gaatacacca atcgactacc tttaagttac 2219521 acatataaac atgtactttg acattataat ataagccatc agtcaggtca actaagtgag 2219581 ttcacttttc cgtcatgagt gcgactgcct gtctatataa tgaaagaaag gggttggtga 2219641 ataggatgtt aattctgatt agctttactg ctcttatatt attctttctc gcaggcatga 2219701 acatgcttcg aaagggctta atttcaatgg cgtactcaaa aattgaagaa cgtttgcttt 2219761 tatttacaga ccatccgtta aaagcgtttc ttatcagtat tgtatttacg gggatacttc 2219821 agagcagctc agcctttatg gtcattgtca tcggctttgt aagtgcgggc gttctttctt 2219881 ttaagcggac gatcccgatg attctgggga caaatgttgg ctctactttt acaactgaat 2219941 ttattgctat caaaatggat attgtgattt gggttctttt aataggaggt ttattgtttt 2220001 ttctgactgg caggtatcct ttgaaacagc tgggaacaag cttccttgga ctgggcatca 2220061 tcttcttttg catcagcgga ttcagccatc ttgccgggcc gctgacaaag ctgaaaacgg 2220121 gcgccgacgt tctataccat gttaacgatt caaactggtc cgctttgctc atcggcatgg 2220181 tgttaactgc catcattcac tccagttctg tctgtatcgg cattttgatg agttttatga 2220241 atgaagggat tatcggactg acacaggcga tgagcgtcgt actcggatca aatatcggga 2220301 catgcattac agctgtcatg gctgctgtat ccggcggata tgcggcgaaa cagacagcat 2220361 atgcccatgt ggtatttaac gtgctagggg tggctctagt attgcctttt ctgaccgcag 2220421 cgaccggctt tgtagagcag ttatcacctg atcccgcaca aaagatcgcg catttcagcc 2220481 ttttatttaa tgtggtgaca gctcttttat ttcttccgct tacaaacttg ttttaccgat 2220541 tgattcacct tcttatcccg gctaaataaa aaaatcggta cattttaatg caccgatttt 2220601 ttaggttaag aagacaaacg catgtgttca gttatttcat cctcaaccac acggacaaac 2220661 tgtccttcgt tgtaaggata acctgctttt aggattttga cttttacgat tttgccgatc 2220721 atatcttccg tacctttgaa aacaaccttc atataattgt ctgtgtaacc gacaaacata 2220781 ttttcttctt ctgtttcctt aaacgcttcc tcagggataa tctcaagcac ttcattttca 2220841 tactgagaag cgtattcttt tgcaagctgg tcagaaagag caatcaggcg gtgcacacgt 2220901 tcgtttttca cgttttcatc cacttggtct tccattcgtg cagctggtgt tcctgtacgc 2220961 ttactgtaag ggaaaacatg cagctcagag aatttatgtt ctttaataaa gttataggtt 2221021 tccataaatt cttcttctgt ttctccaggg aacccgacga tgacatcaga agtaacagct 2221081 aagcctggca gtgctttttt caatttattt aaacggtctg caaagaattc cattgtatat 2221141 ttgcgtctca tccgtttaag cactgtgttt gatccggatt ggataggaat atgcaaatga 2221201 ttcactatct tatctgagcg gtctaagacc tcgatcactt cgtcagtgat ttggctggct 2221261 tcgattgaag aaattctgat ccgtttcacg ccttccacac gggtgtctaa ttcgctcaaa 2221321 agcttcgcga agttgtaatc tttcatatct tcgccgtagc cgcctgtatg aatacccgta 2221381 agaacaattt ccttatatcc ggcatcgaca agctgctgcg cttgtttaat gacttcttca 2221441 gggtcgcggg agcggagcag gcctctcgcc cacggaatga tacagaatgt gcagaaatta 2221501 ttgcagccct cctgtatttt caatgacgct cttgtgcggt ccgtgaaagc aggcacatca 2221561 agctcttcat atactcttgc tttcatgatg ttgctgacgc cattaatcgg ctggcgttct 2221621 tctcggtatt ggtcaatgta gccaagcatt ttttcacggt cctgtgttcc gactacaatg 2221681 tcgacaccgg ggatcgccat aatctcagca ggtgaggttt gcgcgtagca gcctgtgaca 2221741 cagatgacac cgtcaggatt ttgacgaatg gcgcgtctga tcacttggcg gcttttttta 2221801 tctcccgtat ttgtaaccgt acatgtatta atgacatata catcagctgt ttgttcaaag 2221861 tctcttcttt catagcccgc ttctttgaaa agctgccaga ttgcttctgt ttcataatgg 2221921 ttgactttac agccaagcgt atggaaagca acagttgcca ttactgatca cctcttaata 2221981 actctgtttg ataagaaatc gcactcaacg cgtatagcgg agcggtttct gtccttaaaa 2222041 ttctcggtcc aaggccgcac gtcacaccgt cttgctctgt gagccgttca acctccgctt 2222101 ctgttaaacc gccttcggga ccaaatacga tcaatagaga tgatcctttc ggaaggctgc 2222161 ttacaatcgc gctgaatgcg cttatttccc cttgcttcga tgactcctcg tatgcaacga 2222221 cacatttatc gaaatcctgc atcctttgaa gaagctgctg aaaagaatgg acatccatca 2222281 ctcgcggcac ttcgttacgg tacgattgct cagccgcttc cttcgcaatt ttcgtccatc 2222341 tttcccgctt tttctttgcc tttttgtcat ccagcttgac aacagaacgc gcggcttgga 2222401 aaggaataaa ggcatgagct ccgagctcag tccccttttg gataatccat tcaagcttat 2222461 ctcctttcgg aaggccgctc gcaatataga cctttatcgg aagctctctg ttttcattcg 2222521 tccattctat cacaaggcag gacactttat ctttggaaac agattgaagt tcacattttg 2222581 cctcgaagcc gtcttgagag cagcagataa tctgatctcc ctcattcatt ctcatcacgt 2222641 tcacaatatg atgaacttct tcgccggtaa tcgaaaaagt cggcgcttcc tctatttgct 2222701 gcttcgtgag ctcgataaaa tatcgttgca tacgctgtga cacctactaa ctgttatttt 2222761 ttcgcaataa tgctgaccca atcttccatt gaaaggattt ctacaatggt aaagccagct 2222821 tgttccagtg cttcttttac ttcttgtttt ttatgaccga tgattcctga cgtaataaag 2222881 tgaccgcctt cttttaacag gctgtacgct tgtgaagtaa agcgaagaat gacttcagcc 2222941 aaaatgttgg ccacaatcac atcatgttcc ccttcaatcc cgtctaacaa attgttttgc 2223001 ttcacttgag caatatcgct gactttgttc agcttgagat tgaggcgtgc actttctaca 2223061 gccacgggat caagatcgta ggcatgaacc gattcagcct caagcattgc agccgcaata 2223121 cttaaaattc ccgaaccagt gccgacatca atcaccttat cacccttttg cacaaagcgt 2223181 tcaagcgcct gaatgcagag tacggttgtc ggatgtgtcc ctgtgccgaa agccattccc 2223241 gggtccattt caataatcag ttcatcagta tggaccggcg tatattcctc ccacgtcggc 2223301 acaattgtaa acttttcaga aattttcaca ggatgataat actttttcca ggcagtcgcc 2223361 cactcttctt catttacttc agaaatagtg atgtggtttc tgcccaaatc aatattgtaa 2223421 agaaggagat tattaatcgt ttctttgatg ccgtctacag tttcgcccag aaaactgtta 2223481 accggcagat atgctttgac aatgacaccc tcatctgggt aatcattggg gtcgagctgg 2223541 tagatttccc cgtacacatt ctcacgttct ttaattaaat caagcgggtc ctctatcaca 2223601 accccacttg caccagcttc atgcaatata tttgagatag gttcgaccgc ttcatgtgtt 2223661 gtgtgaatgc ttaattcgga ccatttcaaa actaccaact cctcatccaa taattaatcg 2223721 cctttaaacg cgcgttttac cttgtcaaag aaactcattt cctgttcgtc aggcaggttt 2223781 ccgctgactt cggcaaattc gcggataatg tctttttgtt tatcagtcag atttgtcggc 2223841 gtaacgacgc ggacgacgat atgctggtca ccctgtccat agcctctgac attttgaacg 2223901 cctttgcctc ttaatctgaa tttcgttcct gtttgtgtac cggccggaat tttcaatttc 2223961 acttttccat gcagcgtcgg cacttctacc tcatctccaa gagcagcctg agcaaacgtt 2224021 aacggcattt cacagtaaat atcatcgccg tcacgctcga agaactcgtg tgcgcgtaca 2224081 tggaacacga caaataaatc cccggcaggg ccgccgttta ttcctggttc accctgtccc 2224141 gagagacgaa gctgctgccc gtcatctaca ccggctggaa ttgtcacatt gattttcttg 2224201 cgttttttga tttttccttt gccgccgcag tccgcacatt tgtttttaat gattttgcct 2224261 gtaccttcac agtggtggca gacccgtctg ttaacgactt ttccaaacgg tgtattttgc 2224321 tccacgttta actggccgga gcctccgcag tgggagcatg tttctggatt tgttccaggt 2224381 ttcgcacctg agcctttaca tgtttcgcac gtttcctcgc ggggaatttc gatggttgtt 2224441 tctttaccga aagccgcatc ctcaaacgac agggtcatcg tatactgtaa atcagcaccc 2224501 tggcgcggag cgtttggatc tcttcgtctt gtgcctccgc cgaatatact tgagaaaata 2224561 tcatcgaaac caaaaccgcc gaaatcgccg ccgccaaaac ctccgccgcc gaagccttgg 2224621 ttagggtcag tgtgaccaaa ttgatcgtaa tgcgcacgtt tttggtcatc tgacagcgtt 2224681 tcgtatgctt cttttacctc tttaaatttt tcatctgatc cggcttcttt gttaatatca 2224741 ggatgatatt tttttgacag cttccgataa gcttttttaa tttcatcctt tgaagcgctc 2224801 ttacttactc ccagcacttc atagtaatca cgcttactca tctcgcttca ctctcccgaa 2224861 tttctcacat aaattagatt gtatcatttt gaattatgat ttttcaattc cttttatccc 2224921 gggcaagaaa aaaagtcaaa gccaagagat gcctgacttt gactttctaa tcattgaatc 2224981 agattatgaa atgtgttctt ttcggtcagc tccggaagcg gggctgacac taaaaagaac 2225041 ttattttttg ttttggtcgt cgtttacttc ttcgtattca gcgtcgacaa cgttgtcatc 2225101 cgctttgcct tcagcgtttg ctccgccttg agcttgctgt gctttagcag cttcttcata 2225161 aagcttcata gaaagctctt gaacgattgt ttgaagctca tcttttttcg ctttgatctc 2225221 ttcaaattcg tttttctcaa tcgctgcttt taaagcgtct ttggcatcgt tggctttttt 2225281 cacttgttct tcgtccactt tgccttcaag atcttttaat gttttctcag tttggaaaac 2225341 aagctgatct gcttcgttgc ggacttcgat ttcttctttt ttcttcgcat cagcgtcagc 2225401 attttcttcc gcttctttta ccatgcgttc gatctcttca tctgagagac ctgaagaaga 2225461 tttgattgta atgttttgtt cttttcctgt gcctaagtct tttgctctta cgtttacgat 2225521 accgtttttg tcaatatcga aagaaacttc gatttgaggc acgccgcgcg gtgctggcgg 2225581 gatatcagta agctggaagc ggccgagtgt tttgttgtcg gcagacattg ggcgctcacc 2225641 ttgaagaaca tggatatcaa cagctgtttg gttatcagca gcagttgaga acacttgaga 2225701 tttgcttgtt gggatcgtcg tgttgcggtc gatcagtttt gtaaacacac cgcccattgt 2225761 ttcgataccg agagaaagcg gtgtaacgtc aagaagaaca acatctttta cgtcacctgt 2225821 gataacgccg ccctgaatcg cagcaccaag cgctacaact tcatccgggt ttacgccttt 2225881 atgcgcttct tttccagttt cttttttgat tgcttcttgt acggcaggga tacgagttga 2225941 tccgccgaca aggatgactt tgtcgatttc gcttgcagaa agtcctgcat cttgaagcgc 2226001 ttgacggaca ggacccattg tgcgctctac taaatgagaa gaaagctctt cgaatttagc 2226061 gcgagttaat gtaagttcaa ggtgaagcgg tcctgcttct ccagctgtga taaacggtaa 2226121 agaaatttgc gtagaagata cgccggaaag atcttttttc gctttttcag ctgcgtcttt 2226181 caaacgctga agcgccattt tgtcttttga caaatcaatg ccgttttctt ttttgaattc 2226241 agacaccaga tgatcgatga taacttggtc aaaatcgtcc ccacccagac ggttgtcgcc 2226301 ggcagttgaa cgaacttcga atacaccgtc gccaagctca aggatggaaa cgtcgaatgt 2226361 accgccgcca aggtcgtata ctaggatcgt ttgatcttca tctgttttat caagtccgta 2226421 tgcaagcgct gctgcagtcg gctcgttgat gatacgttct acttcaagac ctgcaatttt 2226481 accagcgtct tttgttgctt gacgctcagc atcgttaaag tatgcaggaa ctgtgataac 2226541 tgcttttgat actgtttcgc caagatagct ttcagcgtat gatttaaggt gttgaaggat 2226601 gatagcagac acttcttgtg gagtgtaatc ctttccttca atttcaactt tataatcagt 2226661 acccatatga cgtttgatag acataattgt gttagggttt gtaatagatt ggcgtttagc 2226721 cacttcccct acttgacgtt cgccgttttt aaatgcaaca actgatggcg ttgtgcggtt 2226781 tccttcagcg ttagcaataa ctttaggctc gccgccttca agcactgcca cacatgagtt 2226841 tgttgttcct aagtcgattc cgataacttt actcacttga ataacctcct gctatgtaat 2226901 tattgattca ctttgaccat ggaagggcga atgacgcgat ccttcagctt atagcctttt 2226961 tgcatttcct caacaacaat gttggagccg tagttttcgt cttcagcctg cataacagct 2227021 tggtgcagat taggatcaaa ttcctgccct acagcttcga tggcttcgac gccttctttt 2227081 ttcaaggctt ctacgagctg acggtggacc atttccattc cctggagcaa acttttcgtc 2227141 tgttcattgt cggcttcaac ctgaagcgct cgttcaaaac tgtcaagagc cggcagcaaa 2227201 tcagtcacga tattttgaga acggtatttt tgggacgctt ccatctctaa acggctgcgt 2227261 cgtttatagt tttcaaagtc tgcttgaaca cgcaaaagtt tgttttcttt ttcctcaagc 2227321 aaaccttgca attcgttaat ttggttttga agaagttcgc tttcatttgt ttcttcctgc 2227381 tgttcatcag cggcagcttg ttcttcaatg atttcttgct cttctgtttc gttttgttca 2227441 acggtttgtt tttcttctga cattgtgttc acctccctca aagtgtaagg agaaggacag 2227501 gtgctgccct tcgataaaat ttgccaaaat tcccttattc atcatacaga cttgttaatg 2227561 cttttgacaa gtccgaagtc acatgctgaa gcaggctgac aaccctggaa taattcatgc 2227621 gggtcgggcc gataatcgca attgagccga tctgcttctg gtctacggaa taagaagccg 2227681 taatcagact gcaattttcc atctcttcat agtcgttttc ttttccgatt ttaatcgaaa 2227741 ttcccgtgtg cggggattga accagcttta aaacatcctg ttctttctca attaatgaaa 2227801 gcagcgaccg aactcgggtg atatcatgga actcaggctg gttcagcata ttgattttcc 2227861 cgccaaaaaa caacttttca acgtgatttg tggaatgaaa ggttgaacga agcgcgtcga 2227921 gtatattgtc atagttttta atgtgctgtc ttaggtacat gacaacttct ttaaatatgc 2227981 gctcattcag ttcatccatt ggaacgccgc ttaaacggtc gttcagtata tttaccagtt 2228041 tttcaatatc agacagatcc attttggtcg gaaagttaat cgttttgttt tccacatgcc 2228101 ccgtattggt aacgagaatc gctaccgcca tatcaggctg aatcggaatg atttgaatct 2228161 gtttaaggta attctcactc aacttcggcc cgagtacgat ggatgtgtaa ttcgtcagat 2228221 cggacaaaat ttgcgctgat ttttgaactg tcttctccag ctcgaaaatt ttctctttga 2228281 agatcgagtg gatttggtcc aggtcgcttt tcgtcaattt gacgggtgac agcaaatggt 2228341 caacatagta ccgataccct ttttctgacg gaacacgtcc tgaggatgaa tgggtttttt 2228401 caataaagcc caattcctcc aagtcagcca tctcgtttct tattgttgca gagctaaatg 2228461 tgatttcatc ttttttcgaa agagttcttg atcccaccgg ctgtgccgat ttaataaaat 2228521 cgttgattat aacctgaagg atcagcagct gacgatttgt taacatcatc atcacctctg 2228581 ttagcactct caataagcga gtgctaattc tataacaaaa gtatcaaacc acaagaaaaa 2228641 tgtcaattat aactcaccca aaaaagcgcc aaaaacttca ttgcctaata atttcccttg 2228701 atgagtcaaa taaacggcag actccgaatt gtgaatcagc cctttttcag cgaggtcttt 2228761 taacacgctt gggaaaagtc catccaggga acggccgtat ttttctgcga atcgtttttt 2228821 gctgacaccg gctgtttttc tcaaacctaa aaacatttct tcctcaatct gttcttctgt 2228881 tgtcacttca tgtgtatctc tgtacggaaa acccttttca gctatcaggt caatgtaatg 2228941 cttaacaggt ccgacgttca ctgttcgtgt gccgccaata tatccgtgag cgccagctcc 2229001 gaaaccgaaa tattgttcgt tgctccaata cgttagattg tgcttagatt ccatgcctgc 2229061 cttagcaaag ttgctgattt catattgatg aatgccgtga gcttccatct tgctcatcac 2229121 tatttcatac atttcagctt cctgctcctg cggcggaaga tgaagccgcc ctttttgcat 2229181 caaattataa aataccgttt tcggttctac aataagggag taaacggaat aatgctcagc 2229241 gtccaatgat aaagcagtgt ttatggaatg ttccagatgc ttgagggttt gccccggaag 2229301 cccgaacatg agatcaagac tgatattctc aaaaccgatt tcccgcgctc tttcaaaaga 2229361 ggtgaataca tctttttgct tgtgcactcg gccgattttt tctaacagat cgtcttcgaa 2229421 cgtttgcaca ccaaagctaa ggcgatttac gcctgcttct tttaatattt ttaatttctc 2229481 tgcggacaaa tcgtccggat tcgcttcaac cgcaaattcc gataagtcgc ttgagggctt 2229541 tagcacgcgg ttgatcatat ccatcagctt tttaagctgt tcctcagaca gggaggtcgg 2229601 cgtgcctcct ccgataaaga ttgttttgag atcaggctgc ccggtttttg ctattgtatt 2229661 tatcatttcc tgttcgagtg cgtttaaata ctcgtcgact ggctgacttt gaataaaata 2229721 tttattgaaa tcgcagtagt ggcaaatatg ctcacaaaat gggatatgga tataagctga 2229781 tttcaacgga ttcaccttct ttacagaaag aagccgcagt acaagactgc ggcggcttct 2229841 attgtttttt cggactgtcg tccattttca gaactgccat aaatgcttct tgcggcactt 2229901 caactgagcc gacctgcttc atacggcgct ttccttcttt ttgtttttca agaagtttcc 2229961 gtttacgcga gatgtcccct ccgtaacatt tagccaatac gtttttacgc attgctttta 2230021 tggtggagcg ggccacgatt ttctggccga ttgcggcttg taccggaact tcaaactgct 2230081 ggcgcggaat gagttctttc agtttttcaa cgatcacttt tccccgttca tatgcgtaat 2230141 cacgatgcac gataaaggaa agggcatcga ttttttcacc attcagcata atgtccattt 2230201 tcacaagctt ggacggtttg tagccgatca gttcataatc aaaggacgca tagcctttag 2230261 tgcttgattt cagctgatca aaaaactcat atacgatttc cgctaatggc atatcataaa 2230321 tgatgctgac acggtttgcg tctaaatact gcatatcaat gaaattgccg cgttttcctt 2230381 ggcaaagctc cattacagcg ccgacatagt cattcggcac catcatcgtc gcttttacgt 2230441 atggctcctc aaccctttcg atcttttgag gatccggcat gttggacggg ttgtcgacaa 2230501 cgaccttttc gccgtctgtc atatacacgt catagataac gcttggcgct gtcgtaatca 2230561 ggtcgatgtt gaactcacgc tcaattcgct cctgaatgat ctccatgtga agcatgccta 2230621 aaaatccgca gcggaacccg aatccaagcg cttgcgaagt ttccgcttca tattgaaggg 2230681 aggaatcatt cagctcaagc ttttcaagag cttcccttaa atcattatac ttcgctgtat 2230741 caatcggata caaaccacag tacaccatcg ggtttagctt gcggtatccc ggcagcgctt 2230801 cttctgcagg attggcagcg ctcgttattg tatcaccgac acgtgtgtca ccaacatttt 2230861 tgattgaggc agtcaggaag cctacatcac cgaccgtcag ttcatttgtc ggagttgctt 2230921 tcggcgtgaa cacgcccacc tctgttactt cgaattcttt gccggttgcc atcattttga 2230981 ttttttgtcc cggctttacc gttccttcaa cgactctgat ataagccacg acaccgcggt 2231041 aggcgtcata aagcgagtcg aagatcagcg ctttgagcgg cgcctccgga tctccggtcg 2231101 gagctggcac cttttctacg atttgttcta aaatctcctc aatcccgata ccggcttttg 2231161 ctgaagcaag cacggcttct gatgcgtcaa ggccgataac gtcttctacc tcttggcgca 2231221 cacgttcggg ctcggcgctc ggaaggtcga ttttattgat gaccggaagg atttcaagat 2231281 cgttgtcaag cgctaagtag acattggcga gcgtctgcgc ttcaatcccc tgggctgcat 2231341 ccacgacaag aatcgctccc tcgcaggcag caaggcttcg ggatacttca tacgtgaagt 2231401 cgacgtgtcc cggcgtatcg attagatgaa agatatattc ttctccgtct tttgctttat 2231461 atttaagctg aacagagttt aatttaatgg ttatgccccg ctcacgttca agatccatag 2231521 aatcgagcaa ttgttctttc atttctcgtt gagtgattgc cgacgttttt tctaaaatac 2231581 gatccgctaa ggtcgatttt ccgtggtcaa tatgggcaat gatagagaaa ttccgtattc 2231641 tcgattgcct ctctaaacgc ttttctttat ctgtcacaat ctatcactcc tactattaaa 2231701 cgcaaaatac actagcttag attatatcaa taggattgta aagattcaat gtaaaacaag 2231761 aaagagaaaa gttccctatc atatctgggt tgcttttctc tttcacgtac ttattgattc 2231821 atatcccgta tccattcata cattgactgg gcagtattgg ttacggtgtc cgaaagcgct 2231881 tttccggctt ttgaaaacat attgaatgtc tccacctttt ccagctcttt ttgtttttct 2231941 actaaatctt ttgccgtgac tgtttctcct aggattgagg cttctttttc attatctttt 2232001 ccgtcggtga gcgtaaacgc ccccttcagt gaagggtcat gatagccttt catactcagc 2232061 atcccgtggt ttgcctgctg catgccgaac agaacgccta aaaacatgat cgtgacaagc 2232121 agtaagcact ttccaaagta tgcaatcaaa tcaaccacct atttcttatt gttttttcgt 2232181 ctccccgctc gctgcgttga ccttttcagc atcccagtac atttcgctga atacgtccgc 2232241 ggccgcgtta gccgcacgct gcagctcttc gagattatta tccactccgc caaactcgag 2232301 caaaagcgct ctatcggtta aatcctgatt gtaaacacca ttatcgcctg gcgagccttt 2232361 ggaaaagaca cctgtgctaa gtccggggta ttttttctcc atcagtttat gaagctcact 2232421 cgcaatttta tagttttctt cgaagttttt gctttttttc ccgacgacaa aggctaccct 2232481 ggcatagctt ttccctttaa tcgttgcggt tgtgtctttt ttgcgccgag agtctctgtg 2232541 gatgtcaatg atatattgca gatttttgtt tgaagcgagg gcgtctttca cgaccggcct 2232601 tgattcatca taggacctgg catagtttaa gcctttttta ttcaattttg actgtatatc 2232661 ggttttattc actgtggctc cgattccctg ggattcaagc gcttgtccga acatatctcc 2232721 tacaagcgtg acattggctt tagaatggcg cgccatgtca ggatcggtct cgccttttaa 2232781 tagagggaga tatgattccg tattgtgcgt gtgatagata aacacgacct ttttatcacc 2232841 tgttgtttgt ttcggcggat ctttttgcgc attatctgat tgcgtttgct gtttttcaat 2232901 ctctgccaaa ttcgcttctc tttcttcctc catcacctta gacggcggcg gcgattccgc 2232961 aggcatattc gtataatccg ttccttgtcc agctaacaaa atctcggtat caaattgtgc 2233021 aaatcctggc agctcccgac cgagaaagct ccgcggatct tcgaggttaa tgctcgtcgc 2233081 cagctttaaa gaaagacgag aaagatgaaa tgagctgtct gtttgagaga ggtcagaagc 2233141 gaaataatgg ttttccatct gcagcaaatg tgcaaatacg tcacccggca attcttcagc 2233201 aatcccataa aaagagtcag acgacggcct aagttccggc cggagagacg tcagcacacc 2233261 ggatagaaca aaaatcacga taaggcttac gataaataga aagatggctt ttaccgcttt 2233321 ccctccattt accgcaacaa caatctgtct gtttctgcgt ttatttctca ttgaatccct 2233381 ccagcgcttg tctagtaatt actctatgaa caagctagag gaagtagaac tgtttagtga 2233441 ttgtaggagc ctttgttttc ttgtgacact ttttcatgaa gcgctgtgtt taatccgttc 2233501 gctaaaacat ttgccatatc gtcgataaat gaatcgactt ccttcggtgt aaccattaag 2233561 ttgtgcccta aaggcgaaag cacctcgtga atgagctgcc gtttttcatc ttcttgaagg 2233621 gttccgacaa tacctaggaa cgattggcgc tgcttttgat cgggaagatc gtcttcagtg 2233681 agcactttct ttttcccaaa cgtcatgcct gccggaacaa gcgatcttga tggcctgtta 2233741 tccttcattt ctctgccaaa atgttttaat atgtagtcca ccgtgtcgct ggcaattgtc 2233801 acggcatcaa ctactgtcgg aacaccgata gcaatcaccg gaacaccaag cgtgtctttg 2233861 cttaaatctt ttcgtttatt ccccactcca gaccccgggt gaatgcctgt atccgatatt 2233921 tgaatggttg tgttgaccct ttccaccgcc cgcgccgcca acgcatcaat ggcgatgaca 2233981 aaatcaggct tcgattgctc aatcacacct ttaataatgt cacttgtttc gattcctgtt 2234041 atccccatta cacccggtgc aaaagcactg acaggcctgt aaccctcctg tacgttttcc 2234101 ggctgaagct taaacaagtg ccttgttacc aacagatttt ctactgccat cggtccaagc 2234161 gcatcaggtg tcacgttcca gttgccgagc ccaacgatca aacagctcgc atcttttgag 2234221 atattaaggt tttcaagaaa agctgagaat tcctccgcaa agacagcaga gaccttctcc 2234281 tgcatttccg aatcattctc cctgattccc tgtgcttcaa gcgttaaata gcgcccttct 2234341 ttttttcccg aaagctctgc gccttccttt gtaacatcaa ctgtgcggat tttaatgccg 2234401 ccgtgatcac gctctttttc aataaagcct ttaatttctt ttgtcggcac agcctgctga 2234461 ttggccattg cttccttcgt ttccactgcc aaatcggtcc gtatcaaata ctgattcaca 2234521 tccagctcac tctttttcat acaggggcct ccttcacatt aagtacctat attgttgcca 2234581 tttgctgaat aaatcatgct aaaaagagaa ccttcaatga aaaatacttt acatttatat 2234641 tgcaatctaa aggtgtgttt gatagaatac aatttgttct attgtgaaga agatttaacc 2234701 ttaagacact gtgctacagg ttgtatctta ggaggtgaaa cacatgccaa acattaaatc 2234761 agcgattaaa cgtacaaaaa caaacaacga acgccgcgtt cataacgcga caatcaaatc 2234821 tgctatgcgt actgcaatca aacaagttga agcttctgtt gccaacaacg aagctgacaa 2234881 agcgaaaact gctcttactg aagcagctaa acgtattgat aaagcagtga aaacaggtct 2234941 tgtacacaaa aataccgcag ctcgatacaa atcaagacta gcgaaaaaag tgaacggact 2235001 ttctgcataa tataaaaacg atcctcaata atggggatcg tttttttcat ttctttttaa 2235061 cagctgtaaa aggaacagtt cgagcaggag ctgcttgtcc tttttcccgg ttttcatctc 2235121 atagtccatg acggcaagct gttcaataat taaacggagc tcctcctctg aaaaaagcct 2235181 tgcttgatcc atcgccagct ttacccgaaa tgggtgaact tttagattag aagcgatttg 2235241 tttttgtccg tatccctgtt ccgcgaagta cttcgtctgc agaatcagcc ggaactgatt 2235301 cgaaataagc gccataattt tgatcggttc ttcattttgt tttagcaaat cataaaaaat 2235361 ttgcagactc tctgttcgtt ttcggttgac gattttattg atcagctcaa aaatattttg 2235421 ttcaaggctt ctagcaacaa gcatttttac atcatccagc gtaatttctt cacgatctcc 2235481 aataaacgtg cagagctttt gaatctcctg aaaaatcgat gacagatgac cgttcacaag 2235541 cagaaccaaa tgctccgccg cttccgtgcc gattgttttc tgctctgttt ttgcaaggtt 2235601 gacagtaaag tctgtcgttt cctttgcatt taattccttc gcctccatca taaacgcgtg 2235661 cttctttaac gctttcgtca gcttttttcg ctcatcaagc ttttcatacg gagcaagcag 2235721 gacaaagact gtgtaaggcg caggtgattg tatatatgat tcaagcgcac tgacgttgtg 2235781 ctcaattttt tcttttttct tttcacctgt taaaaaatat ggatttttca caatgacaag 2235841 acgccgctcc cccataaacg gaaacgtttc agcatctgca atcgcttgat ccagcgggtc 2235901 ctcttccaga tcaaaaacgg acagattgaa atcctttgtc tcctgatcaa cgaccgtctg 2235961 tctgatcctg ctgacggttt cttgcagcag atatgtctct tttccgtata aacaataaac 2236021 cggatggacc tctccttttt tcaggctttt ccacacatca aataccattg ttgtacgact 2236081 tcctctcttt catcatcccc ttctatccta aattgagttt gcaaaatagt aaagaggaag 2236141 cctgactgct gcttccccat ttatattaaa cgcctgttcg caagcccccg ggacagcttg 2236201 taaaaaggcg ataatcacca gaacagaaaa cgttacctta gcttctagat ttttcaaaac 2236261 aattccatta tacttaagtc agtcaggagg gataaagttg aatgattttg aaaaaaacgt 2236321 tcaaagcaaa cgaaatgatg ctgtagattc agctgttggt tttgttgtgt ccttcggatt 2236381 tttcgccttc ttgtttgtca tggcaacggt tattcaccta gttggttcat aacagcgact 2236441 gcccgggctg ctgatttctc ggcagtcttt tttagttcgt ctctgttata tctgatgtat 2236501 catatggagg atagacagaa aaggttccaa ctctgttttt gtatctatat tggatcgttc 2236561 cgttttgatc tgttcgcagc acgcggatag aatgtctctg taatagttgc agaacttttt 2236621 gatgaggatg atggtaccga ttgtttttcc cggctgagat aatggccgtt ttcggctgaa 2236681 gctgttggat gaattcttca ccggtagagc ctttgctccc atggtgcccc acctttaaca 2236741 catctgcttt tatattcgga aacacgttca tcacctcttg ttccccttct ttctccagat 2236801 cacccgtcaa gatccagctc ataccgcccg tctccatcca cagaacgaga gatgaattat 2236861 ttttgcttgc cggatcaggt gcttccggtg acagtacatg gaactgcaaa tcctttattt 2236921 gcaacacatc gcctcgcttc acctcttcaa ttgccactcc ctcttccctg gctgcctgca 2236981 gcactttctc atctttaggt tcagaaacga accctttcgg aatcacgagg cgctttactt 2237041 tatgatgctt cagcagaatc tccgcctctc cgatatgatc ttggtcagcg tgcgtcagaa 2237101 ttaaagcgtc aagctgcttg attcccttag cagttaaaaa cggaatcagc accttttccc 2237161 ccagtgaaaa cggatgctgt ttttcgcgcc aaggctctga cgagtaagac aaagtgccgc 2237221 cggtatcaat taagacacga ccccgctgat gcggagcacc tacaaacatg ctgtcaccct 2237281 gtccaatatc tatcatatcc acttctcctt cggaactaag acacggatat ataaagagca 2237341 gaaacatcac cgtgcagcaa atgcctccgg ttaccatcaa ctgcgacaag gagcgttttt 2237401 caatcgccat aagcaatagg atgatcgtga ctgtgaataa aaaaagcaaa acaggtgcag 2237461 gatgtgcgat cataatcgtg aacacatcaa catctgcaat gtttgtgatt aacctattga 2237521 tccagcttat caataaatca aaccagctga aaaacaatct cccaaacgaa gcggaaagac 2237581 ttaatagaag aacacctgct acagctcccg gcaaaataca gaaggtataa aatggtacca 2237641 tcaacatatt catcggtacg ctgatgatag aaaactgatg aaaatgatat aggagaatcg 2237701 gaagcgagcc cagctgagcg atgagtgata caattgtcag ctgccccaag gaggttttaa 2237761 cctgctgaaa aatagaagag gatagaatta aagaaaaact gacggcgaac gatagctgaa 2237821 aaccggcttc aaagagatga taaggattga agagcagaag gacgatgtac gaaaggcaaa 2237881 ttgcagttgc agagcggaca cgccatttga caagacttcc agctaagtaa acacccgaca 2237941 tgagagcggc gcgtagcact gaaggagcag cgccggtcaa catcacatag agcggcagaa 2238001 ataacagcaa cagaattgac gccttttctc tagttatacc aaggcggatc atgatataaa 2238061 acaaacctgc tgtcaaaatc cccacgtgga gtcctgatat tgccaagaga tggacaacac 2238121 caagcttttg atacgcggta agcacttcat cctccacgta aaatctgtca ccaactgtaa 2238181 gtgcctgtac aatccctgtc gaatcaggag gcagaaggct gtttgtgaat gatatgatat 2238241 gttttctcaa gctgagcacc ttgtacttga aattttcagg ttcgctgcag ttttggatag 2238301 acgtgacaga gtagttccaa tgaatatgct gccgataaag atactcgtta taatcaaatg 2238361 cacccggcac agttgcgtga ttcggttctt ccaatgtacc agtcaactca catgacattc 2238421 ctggttctat gtataacagc tgttcttttt caccagcaga ctgaatgcga tacgcagcag 2238481 cccatttttc cttatcaggt gtctcaacca tcatagacat acggtcgccg tcaattttgg 2238541 gaatagtgtc aatcactgcc ttgaattgat aggttccctg ccgataggaa gagacattct 2238601 gagaatctgt gactgcatac agtacaaaaa acaatataaa agagaagaaa caaacaataa 2238661 taagaaaagc gtgcctcgtt ttgattaaaa tgatgaggag aaagaggatg aaaagaaaaa 2238721 tagcggggaa ataagcggcg gcagtaattc cagccgttgc cgaagctgcc gccataggca 2238781 ataataagcg cgaattacgc attcatcaca cgtagctcgt gaaaagtgta ttcgcctgtt 2238841 catgtatctt tttcaattct tcctccgcta aaccggcatc agccaatttc cctattagac 2238901 ccgctacaaa tgaaagcttt tctctgtttt tcagatcaac gatcatttca tcgagttcaa 2238961 cctgttcaac agttacaccc gcctgttcaa ataattcctg cgcatacgga tgtgttttgt 2239021 aatcctcagc ataataaacc gttttgatac cagcttgaat aatagatttg cagcattgaa 2239081 tgcacggata atgcgtcaca taaatctcgg ctccatcagt cggcacccca aacttagagc 2239141 attgaagaat cgcattcatt tcagcgtgaa tggttcttgc gcaatgatca tctatcatta 2239201 agcatccttc atctgcacaa tgtacgccgc ccgcgattga cccattgtag cctcctgcta 2239261 tcatgcgttt gtctctgact atagtagcgc cgacagataa tctcggacat gtgctgcgca 2239321 gcgccaataa atggctttga gccataaagt attgattcca tgaaattcgt tccacgttgt 2239381 tccctccaaa tgttgtgttg cctgaccttt agtttaccta tcataatgca tgaccgtcaa 2239441 atcactttac tgtaatggaa gactttattt tctcaaatga cttttcacct attcctgaaa 2239501 ccttagtgat atcttcaatt gtttggaaac gaccgttttc ctcccggtat gcaataatag 2239561 cttcagcttt ggatggcccc acccctgaga tgccttgtaa ctcctctaag gttgctgtat 2239621 tgatattcac cagcgctccc ttccctccat cgctttggac agaccctccg ccaccttgct 2239681 gcactgctgt ttcctctccc tttttcggga tgtacaccac tgtcccgtcc tgcagaatct 2239741 ccgccaaatt tacttgcgct tcgtctgctt gttcactggt cccgcccgct ttctcaattg 2239801 cctgagatac tctgtcccct gttcgcattt cataaacgcc aggatgctga acagcacctt 2239861 tgatgtctat cacaattgtt tcgtttgact cgtcgttgtt tgcttcctgc tttaccactg 2239921 tattttctgt ctctgttggt acagcttgct tcaccggctc tttatttttc cctgtggcca 2239981 gaaagatcat aatcgctgtg aaaacagccg cagaagccgc taaaataatt gctttcttat 2240041 gctgattcaa ccaattcatc gtgcatgttc cccgctttcg tcatatttta ttttcataac 2240101 acatatggtt tagaggataa tagctcaaag gaggggaaac cattgaagat aggctttatc 2240161 ggcacaggaa atatgggtac gatccttatc gaatcattta ttgaatcaaa agcggccgat 2240221 ccctcaaaca tgacaatcac aaaccgcaca attgaaaaag cgttgcacat aaaaaaccgc 2240281 tacaacagca taaacgttac cgaaagtctc gaaaagctcg tttctgaaaa cgagatgatt 2240341 tttatttgtg ttaagccgct tgatatatat cctttactgg caagagcgtt accttattta 2240401 agaaaagatc atattctcat ttcaattaca agccccgttc aaaccgaaca gctcgaacaa 2240461 tatgtgccgt gtcaagtggc gcgagtgatc ccaagtatta cgaacagagc gctggcaggt 2240521 gtttctctcg tcactttcgg cacaagctgc ggcgaatctg caaaagcgaa aatcaatgag 2240581 ctgatgcagc atatctctca tccgctgcaa attgaaagtg acatcacgag ggttgcatca 2240641 gacatcgtaa gctgcggccc cgcttttatg agctatctga ttcagcggtt tatagatgca 2240701 gctgtttcgg aaacatcagt gtctaaacag gacgcgattt tgatgtgtaa ggaaatgctt 2240761 gtcggaatgg gaaaactgtt agaaaccgaa ttgtataccc tgcctgcatt acaggaaaag 2240821 gtttgcgtta aaggcggtgt aacaggagaa ggcattaaag cgctggaaag cggtgtgcag 2240881 gatatgtttc accgggtatt tcaaaatact catatgaagt acgaggagga tatttccgca 2240941 gtgaaaaagc agtttcatgt gtagacgagt atgtcatacg ttcgtctgta ctgcaaaagc 2241001 ataaaaaagc attttaaaaa accatcgttt taggaaacga tggtttttga tttctgcgcc 2241061 ttgaaaaaga ggcgttctga ttgtgctgat ggctcggtat ccgtaaaatc agctgtcacg 2241121 cgatggagct gaaagccgca gttcttaagc atttcttcgt attcttccac cgggaacgtt 2241181 ctttgctcgt gtgtctcatc aaaacgatca tacgcttctc cgttccacac aaaaaacgac 2241241 atatcatgaa tgacagaaag ctcgtcactt ccggcaaagc tctgccaaat atagctgata 2241301 tcttcgtcct ggtcagcaaa tgtgctatcc ggaaagactt ccgcaatttt aaaagatgaa 2241361 tgaacatcaa acagcaggat gccttcaggc tttaataccc gaaaaacact tttaaaggtt 2241421 tcgatcacat cattttttgt ttttaaataa tttaatgagt cacagcatat cacaacagcg 2241481 tcaaattgac cgtcaaagcc ggtaatctct ctcatatcct gctgaagaaa taaaataggc 2241541 tggctactcg ataccttttg ctgggcgaaa gaaagcatct cttcgctgag atcgatgcct 2241601 gtaacctcga agcctttttc ggcaagccgg atggagattt cccccgtgcc gcatgccaga 2241661 tcgagaatac ggcctttttc cgggagagat gcttcaatcc attttgtcca ttgatcgtaa 2241721 ggcgcgtgtg acattagctc gtcatacacg cttgcaaagc cttgataaat cattgattca 2241781 ttccaaagtc aagatctgcg agcggagcgt ctccccacag cttttcaagg ttgtagtagc 2241841 ttctttcatc cttgtggaag acatggacaa ctacatcgcc tagatcaacg agaacccatc 2241901 ttgcttcatc aaagccttcc atctttttga cttgaatgcc gttttcatca gcttgatcct 2241961 tgatttcacg ggcaatcgcc tgtacctgtt tatctgaatt tccgtggcag atcagaaaat 2242021 aatcagcaac cagagaaata ccttccatat ccagtgctaa aatatcctct gcccgtttat 2242081 catcgcaagc cgcagctgcg atctttaaaa tggacttttg gttcattcac aaattcctcc 2242141 tgttcagctg ccagacacaa gccagttata cgttaaaaat gtgtctggaa aaaccggttg 2242201 attttttttc ataagaaaaa ccattgtatt tttaatggac tgaatcagcg cttgattcaa 2242261 atctgtctca gcaagcttac gcacctcatc gacaccggga aatgcccggt ttggctcaat 2242321 gtaatcggca acgtaaatga ctttttctaa aagtgtcatg ccggggcggc ctgaggtatg 2242381 atacctaatg gcgtcaagaa tgtcttcatc ttgaacccct gcctctcttt ggaccaaata 2242441 agcgccgacc ggagcgtgcc agagctccgg attatgatcc aataaatgcg caggcatttt 2242501 ttcacgcgca ataatttgtt tcatttcttc tttcgggcgg aatttggcgt aatcatgaaa 2242561 gattgccgct atttccgctt ttttagaatc ggctccaaaa cgctccgcaa gttcgatcgc 2242621 cgtgttcatc acgccaaccg tatggatata tcggtgttcg gtcaattgct gcttcacgca 2242681 tgcaagtgcc tcctcacgat tcatataaac cattctcctc tacatacttc ttcactttat 2242741 cagggattaa gtagtcagtg ggcttcttgc ttttaaaccg ttcccttatc atagttgatg 2242801 atacctcaaa ttccggaacg tctgcaaaga gaagcggata aggggtttca acatgaaaac 2242861 cggggcgctt tactccaata aattgaatga ggttcagcag ctcgtccagc ttataccatt 2242921 tcggcaaata ttcaatcata tcagcgccga taataaagaa cagctgatca tttggataac 2242981 gctgcttcag taaagaaacg gtatcaaagg tatatgatgg cccttctctt tccatttcaa 2243041 caagctccag cttaaaggac ggattagatt gaattgcaag ctttagcatt tccacgcgat 2243101 gaaagctgtc ggtatagtct tcgttctgtt tatgcggcgg aatttgatta ggcataaacc 2243161 aaatttcatc aagccccgcc tggtacagca cctcattcgc cattaagagg tgaccattat 2243221 gcggagggtc aaacgtgcct ccgaaaattc cgattttctt catttcaacc acctttaagg 2243281 aagctcgatt tgtttatttt cctttgattc cttatataac acaatcgtat tgccgattgt 2243341 ctgcaccaat tgagagcggc ttccttttac aagagcttcc gctacatcgt ttttatcctc 2243401 ttcgcaattc tgaagcacgc tgactttaat cagctctctc gcttcaagcg cctcagcaat 2243461 ttgtttaatc atgttgtcgt ttactccgcc tttacctact tgaaaaatcg gcgttaaatg 2243521 atgcgctttt gaacgcaaaa aacgtttttg tttacctgtt aacattctgt tcctcctaat 2243581 tttcctatta caatagatct cattttttca atattaggct cttgtccagt ccacaattgg 2243641 aaagacaatg ctgcctgttc aacaaacatg cccacaccat cgagtgtttt caagcctttt 2243701 tggcttgctt cttttaaaag tgccgtctgt attggattat acacgatatc acatacgacg 2243761 gcactgctcg cggcacgctg taatgaaagc ggcacatcgt ccacgttcgg atacatgccc 2243821 acagacgttg tatggatgat aacatcatac tgctcaagac gttcttctgc ttcttttatg 2243881 cttaatactt ctttattgtg aaacgaggga gtagcttctg taagccgctt tgctttttct 2243941 aacgtccggt tgcaaatgtc aaattttttc ggggtatttc ggacaattgt tgtaaaaatg 2244001 gctctcgccg ctccgccagc gccgatcatt aagaatgaca gttcagagat gggcttgtct 2244061 aataccttca ttaatgactt cacgaagcct tccccatcgg tattgtatcc gacaagctta 2244121 tctccctctc ttctgaccgt gtttacggca ccgagcactt ttgcactctc atcaatatga 2244181 tccaaataat ccataatgga aaccttgtgc ggaacagtca cattgattcc ttgtacgcct 2244241 agagctctta ttccttttac cgcatcctcc agatcattct cttctacctt gaaggcatga 2244301 taatgtccgt caagcccgag gtctttcaat gatgcgttat gaatatcagg tgacatagaa 2244361 tggccaatag gatttccgat aaccccgtac agctttttca tacacctctc cccttttctt 2244421 aaattaatga acgccgaaca aatacatgaa cgccttttgg cgcgtatgca gttacctttt 2244481 tatcagcgtc atggacagta acccagccta acccagagaa aacgatatct gtctttttgt 2244541 cttttatcgt aaacgtatgg gcgaccaatt caggaaactc atccatttca tctttacccg 2244601 gaggtgtgag caattcccct gcatgctttt cataaagcgc gtctgcattt tcaagttttg 2244661 ttctatgaat catcagctca ttcggcatat agcaaataaa aggagatctt tccccagaca 2244721 cataatcaaa ccttgcaagt ccgccaaaat acagtgtttg ctgatcatta agctggaatg 2244781 tgcgaggctt cagctccttt ttaggagata atattttcag gtccttttta ttgacataat 2244841 gcgccatttg atggttgttg ataattcccg gtgtatcata aagcgatgaa ccgtcatcca 2244901 gcgggatttc aatcgcatca agggttgtgc caggaaattg ggatgttgta ataatatctt 2244961 cttcacctga cacttcttta ataatccggt taataaaggt tgactttcct acatttgtac 2245021 atccgacaac atagacgtct tttccgttgc ggtaatgctc aatcgcgtca attacttctc 2245081 tgattccctg gccgcgaccc gcactgacca aaaatacgtc aaccggtttt aagccaagct 2245141 ctttcgcttc acgcttcatc cattggatca gacgctctct tttcagtgac ttaggcaaaa 2245201 tatccgcttt attgccaact aataagatag ggtttccccc caccaagcgc tgcagcccat 2245261 taatccagct gccgttaaaa tcaaaaatat caacaatttt tacgaccaga gagtccgttt 2245321 ctccaatacc gtgaagaatg ttcaaaaaat catcatcagt taaggagaca tcttgtattt 2245381 cattatagtt tttcagtctg aagcaacgct ggcaaatcac attttctttc gtaagcgatg 2245441 caggcggcgc gtaccccaaa cctgttttgt cctcggtttg gatcgtaact ccgcacccga 2245501 tacaaacaac cttttccatt tcttactcct cccactgaat gtgccctttt cgtttgagag 2245561 cactcagtat tctgcgttcg acctggcggt taaagcgcgt aatgaatccg tcagaggaag 2245621 cgactggcac gaccaaaatc gtatggtagc cgtttcggtt tcccccgagt acatcggtca 2245681 gcagctggtc tccgatgaca acgcagtcct cttttttcag ctccatattg cgcaccgctc 2245741 tattaaaggc tttacccatc ggttttcttg ctttatagat gaatgggatt ccaagcggtt 2245801 ctgagaaaag tttcactctt ctttcgttat tattagagac aattgtcact ttaatgccgt 2245861 gttccttcat ttcttcaaac cactcgatca atcgcggcgt cgcgttcggc ctgtcccatt 2245921 caacaagcgt attatccagg tcagtaataa ttccttttac atttcgttcc tttaatttct 2245981 caggtgtaat atgaaaaata ttttttacaa actcgtcagg taaaaaaaac ttttttaaca 2246041 aaacccgcac ccttcccttt ttctttcttt caaaatgatt gtcgaaaaaa atcgaacttg 2246101 cgcctaaaga aaaactgagc aaaaaaattt cgacaaaaat tgggtttctt caccaggtgt 2246161 ggataaattt acacacacta tccactctta ttacatcact ctttagacaa attataaaca 2246221 cgatactcac aagttatcca ctttttggtg tggataacag aacgattgtt cttatatgca 2246281 tttcatggta gattaaagat aacttcaacc tcagatgaat gcaacttatc attgtatgcg 2246341 ttaaaatcat gaatgattcc aacttttaag gaggtgcctc tcccattaat tgggttccta 2246401 gcatgagaaa actgtctgat gaattactaa tagaatctta tttcaaagcc accgaaatga 2246461 atttaaaccg tgactttatt gagttaattg aaaacgaaat aaaaagaaga tcgctcggac 2246521 atattatttc cgtatcttct taataggaat ttgtctattt tttccgggcg tatttccttt 2246581 ttttactcag atgactgata ttatatcact ttggctgcgc gctttactac tattttcagc 2246641 aaaaaacacc cctaaaaaga ggtgttttaa agggccggtt attatgctaa ccagtatatg 2246701 ccgcccacaa caaggagaac aacaactaaa acaacaataa aagcgtatcc atatgctctg 2246761 cctgcgccat acatgtgaag cgcctcctta ataaggtttt ataacagcct atgtaggaga 2246821 aataaatcgg actaggcggt tgtccggctc aacgctgcag gatctgccca tcttgtattc 2246881 cttcatatac gatccttgcc cctttaggtg tcatatgatt tccagaagga tctataagac 2246941 cagattggat aagcgcttca tcagttgctt ttccgccgtc tgcttctata aaatgcttcc 2247001 agttatctac aagagggaca tccaggcgct tcgacacatc tcttgtaata tcgttatatg 2247061 agttgtgcca tttccttgct ccgccttttg gttcaaaagc agctgcttga tatctggaat 2247121 agtaaaacaa atgatgcttc ccattacctt ctataattgg gatacacgtc attaagattg 2247181 gcttgatccc gtgttttctg ctttcttcaa taaaataaac cagattttct ctaaaacgct 2247241 gcttcgacac tctcggtttc ccctcagtca gtatggcagc gtcattggtt ccgaacataa 2247301 taaacaaata cttcggtttt tgatccagca catctgtctg aaatcggaga cgggcatcct 2247361 ctgtcgtctg tccgccgatt cccgcattga gtatatcaag gttaccgcgc tcagctgttt 2247421 ttaatatatt gacccactgc tgtgcttttg gataatcgcg ataatcccaa ttagagccac 2247481 gcgtattact gtcaccaaat gctacaacgt cttcgtatcc ccttccctcg catcctgctg 2247541 taacgaacag cagaaggaaa aggatgataa aatgtttcat ctttacaccc ccaaaagcct 2247601 cactttaatg ttatacctct gtttctcttc gttcaatgaa gagtttttcg ctatcactgt 2247661 tttttcctat agttaacgtg tccccctcag tgaatatcat tctgctttca ttgcggcgca 2247721 gctgatgatt ttttaaaatt cccttctttc caatctgaaa aacacacaaa ccaaagaaaa 2247781 gaaaataacc tgaatccgca ctggaaacag gttatccgtt aaatcctgca tttactttaa 2247841 cttcgattta agcttggcct ttgtttttgg cccataaatc ccgtctgcag ttaatccgtt 2247901 catgagttga aaacgcttga cggcattcgc tgttttcggt ccgtaaactc catctatgcc 2247961 attgtttttg gctcccttat cagggtaaaa gtgaagtaca gctaaagcct tttgcagctg 2248021 gagaatgttt gtgccctttc gataaggcga agtgagcttt ataaccccag acggcagagg 2248081 atatgatggt gaagtttctt ttggaggtgt atccgaggaa gaaattccgt ttagaaaaga 2248141 gttccagtgg tccaagagtt tccgcggaca ttctttcccg gaccactttt tgtggggaac 2248201 aacacgattt aacggaatat tgttttcctt catcagcttt ctgatcagcc actgggcatt 2248261 tgatgttgct ttttcaaaat cgccgtcagc attttcacag atttcaatcc cgatcgattt 2248321 gcggtttcct gtcccgtttg taccgtctcc cgcatgccag ccgttttcat ctatcgggag 2248381 atgctgataa atgactgaat cgtcaactgt aaaatgccag ctttcggatg tgttcgggtt 2248441 tttcacaaac ttggcgtgca ttttcgcatc agcgcctttg gctgtattcg ctgtattatg 2248501 caccgtaata taagcaggcg ccatcgcata gccaggacga ttatcatttg ataccggtat 2248561 aaaatccttt tttatggtta ccatttctat ccctccctat taataagaat gcagaaaaca 2248621 gagagatgga cagccttttt tatgaggtaa aaaagaattg tgttcttaac ctggttttca 2248681 gttgaacagc tgaaatggca ccagttatac taatttagat gacggaggtt ttgactcctg 2248741 acatcaccta agttgggagt gaccatagac atgttaaaaa aagtaatagg tatacttgtg 2248801 attatcgcta tcatttcagt tggttttttt cagaaagaag cttggcttga tgcaatcaaa 2248861 gcaggaggga tgttttccgt tttatttagt atgctgctga ttgctgccga tgtttttttc 2248921 ccaatagtgc cgtttgcttt gattgctgct ttaaatggcg cagtgttcgg gactgcaaat 2248981 ggaatttgga ttacactgac cggctcaatg cttggtacaa tattgctgtt ttttctcgcc 2249041 aggtacagtt ttagagattg ggccagaaaa aaagttcagg cctatcctgc catacaaagc 2249101 tacgaggctt ccttcaacaa aaacgctttt accgctgttt tattaggaag gctgatacct 2249161 gtcatacctt cacttgtaat gaacgtgatc tgcgggctga gccaggttcg ctggcatgtt 2249221 tttttctttg cgtctttaat agggaaaatc cccaatattg ttgttgtcac tattgcaggt 2249281 gccaatttca ccagcaataa attattgtct atcagcattt acggtacata tattctgatc 2249341 atcatgctgg tcatttataa aaagttccct catcttctga aggtgccaaa aaaataagga 2249401 ggcttgttgg cccccttact ttttttctgt cgcatggcct ccaaattcat ttcgaagcgc 2249461 agcaaccacc tttcctgtaa acgtatcgtc tgttaaagaa cggtatctca tcattagtga 2249521 catggcgatg accggcgttg ccgtctgcag atcaagcgcg gtttccaccg tccattttcc 2249581 ttcacctgag gaatgcataa tgcccttgat ctgatccagt ttcgcatcct tagcgaaagc 2249641 tcgctcagtc agtcccataa gccaagaacg aatgacagaa ccatgattcc acactctggc 2249701 aaccttctcg tagtcaaaat caaattggct gttttcaagc acttcgaatc cttcaccaat 2249761 cgcggccatc attccatact caattccatt atggatcatt tttaaaaaat gtccgcttcc 2249821 cgcttcacca gcgtatagat aaccattttc gacggcagta tcacgaaaaa gcggttccac 2249881 aatctcccat gcttcatgat cgccccccac cataaaacag gctccatgcc gtgcgccttc 2249941 cattccgccc gacgttccgg catcgagata atggataccc gcttctttca tttgattgta 2250001 gcggcgaatt gattctttat aatgagagtt tccagcttcg ataatcatat cgcctttact 2250061 taataaaggt gatacatcac gcaaaacagc atcgacaatg ccatgcggta ccataaccca 2250121 taggatgcgc ggcgggtgta ataaagaaat gaactcttta agatttgttg tcccctcagc 2250181 cccgtatgct ttcagttcat caacagccgc ttgatttaca tcatatccaa ccacttgatg 2250241 attgcggtca atgaattgct ttcctatgtt tatgcccatt ttccctaagc cgattaatcc 2250301 gattttcata tctgttcctc ctgattgtct aaaaagcctt tactctttat gttccctatg 2250361 gattgtattg tgatacgcag aaaacaaatg gggcttacat cgtctgcgca tgtaaatttt 2250421 atttttcatg accgacggcg cctgccagtt ctattactga atctctttat atccataatt 2250481 atcgctttat ccttgattta ccatcagttt aagttaaaat atgggaagga attcgatttt 2250541 ttcagtaaaa agaaggtgac atgttgcaga atcaatctca tactcttatt ggagttacga 2250601 aaaccgctgt attcttttta tacgctgcac ttgcaatcat cggttttgca atcgggtatt 2250661 ttattccgca gattgcgaaa tgggcattat ccctcccctg gatccctctt gaaggaccac 2250721 ttcggctcat tacctctttt cagggatcta cagcttcatt tatcactgct cttctcggta 2250781 tgtgtgcggg gatttggttc gctcattctg ttattgcaat gctgctgtct gtcaaaatta 2250841 cagatcacac agtggaattc atcaaaggaa aaaaagtgca aacaattcat tccgatgaca 2250901 tcgctcttgt atttatggat cacaaacggc ttgtcctcct gggaacagcc ggatatgaat 2250961 tggtacggga agaaattgat gaaaaaccag taaacgttga gaaggccttt agacagcatc 2251021 attacgaatg ggcaacagat ggtgatccgt ttaaagatca atttcgccga tggattcctg 2251081 atgcaccaga cctatcgcaa ggcgcccatg ccttattaaa agctcgtcac aaagcactgc 2251141 aggacgaaga aaaagacgat attgaagaat tccgtctcga actggcacag ctgggcatcg 2251201 ttgtacggga cgaaggcaca cgccaatatt ggcgaaaagc agaaacctat cccccgaaaa 2251261 ttcagctcgg cgaaggattg taacaacaga ggctcaagaa agagcctctt ctttactact 2251321 gcacaataaa cagcactctg gtaccgtcag gatagctgct catttgattc cctacccacg 2251381 agccggcgcc gcgattatca gaaggcgtca catatcggac atcagcccct gcaccgcctt 2251441 cctcgcagac cgccatcggc cactcatccc ggtcatagcc cggcttggtc gggattccct 2251501 ttaaagattc ctcccgcctt ttgtctgctc catctctgtc aatggtacaa atatctggat 2251561 gtccctctgc aatcgcatcc ctaatatgac tgccggtttc cggataacga gacagcggaa 2251621 aatataacac tttgtcatac gaagatgcgc cttggatctg ttgcggaacc attaaacaaa 2251681 gaagaactgc tgcagcaaga aacaggcctg ccatccattt tttcatcccc atccccccat 2251741 acctttgttc atttcaatgt atgggcgctt gatgaagaat atttttaaca tttgaagtta 2251801 gtatgctgct taccaaagcc ggactccccc gcgagaaatt tcccggtaca gacacagaca 2251861 gcctcccggt cacatacatt tacatatagg cttttgccta catacttttg tggaggtgac 2251921 gatggtgaca ggtgttttcg cagcgctcgg ctttgttgtt aaagagcttg tctttttagt 2251981 atcttacgtg aaaaacaatg cctttccaca accgctctca agcagcgaag aaaaaaaata 2252041 cttagagctc atggctaaag gggatgaaca tgccagaaac atgctgattg agcataatct 2252101 tcgcttggtc gcccatattg tgaaaaagtt cgaaaataca ggtgaggatg cagaggactt 2252161 aatctccatc ggaacgatcg ggcttattaa aggaattgaa agctattccg ctggaaaagg 2252221 gacaaagctg gcgacgtatg cagcgaggtg tattgaaaat gagattgtaa ttacaaaagg 2252281 ggggtgcata cacccctctt taatacgttt caatatatat ggtgtcagaa tccacaatgg 2252341 taacttcttt cacgataaag ttaacaattg tttttttatc ttcaagagtt aagttatctg 2252401 caccgattga ttgaaaatag tcgatggctc tttttagagc attttcactt gagctcgtat 2252461 catctaggac tttcattttt gactggattt cgttacactt ttcagtaagc tgattttgct 2252521 ttttttgcag ttcaataatt tgtgctttga tttcatctat gtctaaatca tcgtcatcgc 2252581 ttaggctgat tagcgttaaa agacgcttgc ggcctttttt tgttttctct atctcttttt 2252641 caataagttc taattcatca gacaggtgat ttgattgttc agcctcttta aaagaaacat 2252701 acttttgagg atttgtgatg aatttaaaaa tttcacccca tacatgccgg ttcaatttat 2252761 tctcagacat ttcttttccg cagccgcggt cctttgcgcc agaataattt ttccggcaag 2252821 tatatacata gtagtcttta ccatgtgatt ttcttttctt ccctgtcatg gtatttccgc 2252881 attttccgca tctaaccaaa cccgataaca agtaattgtg agggctgata ctcaagtgtt 2252941 ttcttttact ttgacctaag agttcttgag cataatccca ttgttcagct ggaacaattg 2253001 ctggaattgt cacagtgatt tgttcttctt caggccttat tttaattata gatttgttcc 2253061 ctgcctgctt tgaaacatag gaaccctctg tatcatattt atactgtcta tgttcaccct 2253121 tataggaaga gttcattaat atttgccgaa caacctgcct gtgccatact ttggcgcctt 2253181 tttttgtttt aacccccatc tgagttaaat gtagagcaat accatttact ctgccgaaaa 2253241 aagggctttt atgatcggtg aaatagttaa aaatcatccg aatgattttt gcttcctctt 2253301 ctaatatctc aagagttctt ttctctttaa caaatttata gccatatagt ttagaatctt 2253361 taatgatcat gccttttttc attttttgaa gtcggccgct tgatgtccgt tctttgattt 2253421 tggctttttc aaattctgag attgccccgc gcattgcgaa aaacaattga ccttctggag 2253481 aattggcgta ttcaccattt acaaaaatca aaggtatgtt tcgctttcgc aattcgtcat 2253541 caatgattag ctgattcatt aatttccgag aaagacggtc aggatcgtaa caaatgactt 2253601 gacttataag tcccttgctt gcatcctccc tcaagcgatt caaagccgga cgttctaaaa 2253661 gctctcctga aaatccttca tctgcatact tcagcacatc tttagtccct gctttcttta 2253721 tacaggcctc gatttggctg tcgatgctcg atcccttgat cgcttgttcc tcggtcgata 2253781 cccttacata tattgctatc accctgaatc tccttcctat aaagttttat taaataatga 2253841 tagcaatcgt taatgcattt gtcagcttgc ggtccctcga tgattatcac tttcataaaa 2253901 tgcatcaccc cttgggtaat gctatgtaac agctgtttgt ccaaatgagg agattttaaa 2253961 ttaaactata gtgttattaa acgtttcaat gaatatgcaa aaaatttaaa aaaagttgtt 2254021 gtgacttttc tacactcctt taggtcctca atagaaaaga ttttattttc tatgcctcaa 2254081 cattcgctta ttatagtttt caatgattta ttattatttg agagtacaat ggagtagtgt 2254141 ttttcattgt tagatagtta atgacatttc actggtgtca agttcgtata gctagacatt 2254201 aataaaaaaa ggacacatat aaatatgcat cctttaacaa aagagtttat ttatttccct 2254261 gtttcagcaa attccttcaa cctattccct atttcatcac gaactctttg gaaaaacgcc 2254321 catttttctt cttctgtccc ttgtgctctt gccggatcat caaaacccca atgctcacgt 2254381 tttacatgtg gaggcgtcat cgggcattta tcagcagcat ctccacaaag cgtaacaact 2254441 aaatcagcat tgttcagaat atcagaatcg attatatctg acgtttgatt agagatatct 2254501 ataccaactt ccttcatcgc tttaacagca ttcggattta atccatgtgc ttctatcccc 2254561 gcgctataca ctttccactc atcacctaaa tattgtttag cccatccttc agccatttgg 2254621 ctccggcaag agttccctgt acataaaaag taaatgattt tattctccat atattccacc 2254681 tctacatcga gtgacttcca aagtattttc gttgaaacca taaagcaacc ttaacaagtg 2254741 ctatcatgac tggcacttct acaagcggac caattacggc ggcaaatgct gcacccgaat 2254801 gaattcgata tcaagcttcg cacttaaaca cagcggaatt tataatatat gcttggacag 2254861 ccgtaaaagc cgaactgaac aatggtatga ttttgctcat gaattttgcc atatatatag 2254921 acatgaaggc gataaaaaaa caatgcctgc aacttggact gattatttgg attggcagtc 2254981 caattatttt acatatcact tttgcattcc aacttgcatg ttgcgtaata tcaaccttcc 2255041 gtacatacaa tcacatgcaa ttgaaaatgt agcttggtta tttaaggtat ccccttcatt 2255101 cgctaagaaa cgtttaagca tttattacag gaaactgact caacatttat ttagtcaaac 2255161 tgttacggga aatttatgcc cccccttttt gtaatgaata atgaaatcct catgcatttg 2255221 cgcgcattga aaaaaacaaa aaaagacgtc tcccttcacg atccgatcgg gcaggataag 2255281 gaagggaatg aaataagcct gattgacgtt ttgaaatcag aaaacgaaga cgtgatagat 2255341 acgatccagc tcaatatgga gcttgaaaaa gtgaaacaat acattgacat tttagatgac 2255401 cgtgagaagg aagtgattgt cgggcggttt ggacttgatt tgaagaagga aaaaacgcag 2255461 cgagagattg ccaaagaact cggtatctca cgcagctatg tatcgcggat tgaaaagcgg 2255521 gcgctgatga agatgtttca tgagttttat cgggcagaga aggaaaagcg gaagaaggcg 2255581 aaggggaaat aatgcagaag aagccggatc tcatactccg gctttctcta tttgaaagag 2255641 ttatgaaaat catttttttc atcgctgata agctctccga gaaagacagg caggatcgta 2255701 acaaataact tgacttataa tcctcccgca ggcattcaaa gccggacgtt ctaaaagctc 2255761 tcctgagaaa atccttagat cggtatactt cagtacatct ttagtccctg ctttctttat 2255821 acaggcctcg atctggctgt cgatgctcga tcccttgatc gcttgttcca cgatatattg 2255881 ctatcaccct ggatctcctg cctataaagt tttattaaat aatgatagca atcgttcatg 2255941 catttgtcag tttgcagtcc ctcgatgatt attaccttca taaaatacat caccccttgg 2256001 gtaatgctgc gtaatacctg tttgtcctaa tgaggtgatt ttcaatgagt atgaaaacaa 2256061 ataaaaaaac cgatggtttg taccatcgat ctgttttcta tatcactagg ccctcaatat 2256121 agtaaatcta gctcattggt tatgaaagct tattttcatt acacactata tattcatttg 2256181 ttatcatttc tatacgttta tatcaattat ggtaaaaaat ggttacaaaa acccaataaa 2256241 cgtccaacct aactttttca tcttatttat taagaatttt aacctcttcc ttgtgaaata 2256301 aagaagcgat tttcatctcc aaacagttaa tgctatttca tcgggacatg tctgttaaag 2256361 tagccaataa atacattcgg atatccactt acaaccacga ttcaatttga tccactacag 2256421 atttctgagc tgacattaaa cagatagagt tataaaaatc tgtaccagtt ccctttcaca 2256481 attaggacat ttcggcggcg tttcggcata atgcgaacta atttattaat gttcaacaac 2256541 agaatttcgt ctattggcaa taaagaatcc acaaatcatt gcaagaatgg ccatcgccca 2256601 ccagaacgtt gagatcgcct gatcatgatc gatgataatc aaacgaatga cagctgtgat 2256661 gccaatataa atgaagtagc gaagcggaaa atgaaagtct gatttgaagt atttgataat 2256721 caaagcaatg aactcaaagt acatgaagaa tataagcagt tctccaagca tctcataata 2256781 gctgtccact ttgttgaaca gtgacttgta tacgaatagc acaatgtacc aagtctcgct 2256841 gatcagaagt gcgcttaagg ctaacgccag aaagaacaga cagacgttga gaagcgcttg 2256901 taacaggtaa ggcacctttt tgaatttgtt agaaaatctc atcatgttgt ctcctatttc 2256961 aatatattcg tggtttttat tctcagccta catcttggtg ttccaaaatc gtagcacaat 2257021 gtagtactta gaattctttt gtatactgtg aaactgtccc tgcatgcggg acatcattcg 2257081 cgcaatgctt ctttcaccga gtccgttgct ttccggtgtt atatctgcaa gtttaatcgt 2257141 attgctaaca tggatctcaa atatctcttg atccgataca aacgtgatac tgattttttc 2257201 ttccggatct gcgtatttca ataagtttga catcacatta tcaaatacac gaccaagctc 2257261 ctccaaattc acgttaatat aggtttccgg cagctcgcct gaaatatgga cccgaaaatg 2257321 ctcctgatga aggatagcaa tctgatctga tattagatcg tagatcactt ctttcactgc 2257381 aacggtctcc agatcggcct catattcctt gttcagcagg aaatacgcaa acagattgtc 2257441 agacaagctt tttaattgca gtgctttacc ataagcattg gctacatacc gatctttgct 2257501 ggcacccgct tcgcctccct cttttttggc aaactccaga ttcatgatca gcgacgtcag 2257561 cggtgtgcgc atatcgtgcg acatttcggt aaccaggctg cggctctcag cttgcaattc 2257621 ctcgatagct ttaagtttat ccaggaaagc tttccgcaga tcctcaatgc tctttgcaat 2257681 catcgctaat tcatcatgcc cttttatcgt catctcgtag tccagttcgc ccccttcaag 2257741 aatatgaatc tcttgatgaa tcgttttaag gtagcgaaga ctttggcgaa ttccgaagag 2257801 aacaatgatt aaaaagatga gggttgcccc gagcaaatcc aatgcaaagg ccagatcata 2257861 atatcgggaa gagtagaaac cgtcgataat gactcgtcct tcaccatcgc taaacttgac 2257921 aggatgtgaa tgattttgag cgtactgagt cagcttttcc tttccataat ccgattcgga 2257981 ataaatagaa tcatattgca gctcctgatc cttgaatatg gtgaggttaa tgtaattttc 2258041 ttttttgacc cactcgccaa acgcttttct atctgatgta gacaactcat tttctgaaac 2258101 gtacttgctg aatttttgaa tgtatcttgc tgactcctcg tgataatact cttccgaact 2258161 cagatatccc tcgatcagat catctgtgat cttttgcaac gtcagaaaga tcacaccact 2258221 cacaatcgca gcaaccatta tcagcaaagc cagttttttg gttagcgtaa atttaagatg 2258281 cgccaaatcg atatcctctt ccccattcag tttttatata aaccggacgt gccggatcat 2258341 cctcaatttt ggagcgcagc ttccgtatat gcaccatcac cgtattgttg gaacagtaaa 2258401 agtaaggctg tccccacaca ctctcatata tattttgggc agaaaatatt ttgttgcgtt 2258461 tgttcatcag aagtttcagg atacgatact ccagatctga caacttgatt tgcttctcct 2258521 ctttccacac ctcattaaat tcttcgctca ctcttagttt gcccccgata agaaatgttt 2258581 cttcctgttc cttcttttcc tgatagatag tatatctgcg taattgagca atcactctag 2258641 cgtgaagttc ctcttccgag aatggtttag tcatataatc atcgccgccg gcgagtaatc 2258701 cctcagtttt atcgagtgta ctcgatctgg ccgtcagaaa cagaatcggg acgttagagg 2258761 atttcctgat gtgctgacat gtttcaattc ccgaaatgcc tggcatcata atatccaaaa 2258821 taaccaaatc aagcgagtca ttcacaagtt gcaatgctcg ctttccatcc ttggctctta 2258881 gcacctcgta acctgcacgt gtaagggatt cctccaaaag atcaccaata tcctcatcat 2258941 cctctacgac taatattcga taggccatgt ctctctcacc tcatgattct tgttgttatt 2259001 tctcgtgtgt ccttactata tatcgttcat agtaataagt acgttataag atactacgta 2259061 aatcttaaca atttatgaaa gctgatgctc gccacaaatt tgtcacattt tctaaaaaaa 2259121 atgatgactc ttcataaatt gttaagattc ggtctttata tttatccatt gtaaggctca 2259181 agtttttcag atccgcacta cacattgccg tgataaatgg gaaaggagta ttgatatgat 2259241 tgtacaaaaa gaaggacgcg ggcaaccggt gagtctgcgg gaacgggttc attttctgga 2259301 catcgtacga ggatttgcct tgcttggcat tattattgtc aattattttc tgatcgtaga 2259361 ttcagtaaag ggattcgaaa tggcctccga tgacgtactg cataagctgg tttcctggtt 2259421 tgccgaaggg aaattcgtta cgttattctc cttcctgttc ggagtcgggt ttatgatctt 2259481 tatggatcga gccgcgcaga aggtagagag tcccaacaag ctgtttgccc gcaggttatc 2259541 tatcctgttg ggatttggca ttttgcacat cacatttgtt tgggtcggtg acatattggc 2259601 cttttacgcc gtaagtggct tcctgttact cgccttctat aaacgcacgg ccaaaacggt 2259661 gcttagatgg attatcgcac ttatcgtgtt tcaattcctg actcctgttt tcacaatgtt 2259721 gtacaatgtc atcaatactg cagggtcaaa aaacccgaat ttttcagagt ttactttgtt 2259781 tagccacagc agccttacct acatggaatc catcagcact cggtggacag atatggtcac 2259841 gatggctgcc ggctctttct ctatgatcta ttccatgttt ctcatgtttc tgctgggcgt 2259901 gtactttgtt aagatggaat ttttcaaaga catggaagcg aaaaagccta tatggaagcg 2259961 tatctggatc attagcacaa tcgcttttct aataacacaa agcagtatat tactagacat 2260021 gtttaatctt tctgagaata tgctgtggaa ggacatttcc tctgtcttgg gtcaaaatgg 2260081 cggcttaacc ggaagtatgt tttatatgag cacttttgca atgctgtttc tataccttcc 2260141 tcagctgcga ggccctatga tgatattcac caaagtcgga cggatgtcat tgacctgtta 2260201 tctgcttcac tctatcattg gaacagttct gttcctcagg tacggattcg ggcttgcgga 2260261 tcatattcaa tccgccggca cgttcatgtt cagtctggcc gtgtacttcg ttcttatgag 2260321 ctttagtaca ttgtggttga aacggtttag gtacggtccg atggaattag tatggcgcaa 2260381 gctgacgtac ggcaaagtaa acgggagtcc caaagcaact ccgctgcatt cggaaaaatc 2260441 tattcagaaa taaccccctt gcacagattg catgacttca aattagtgtt gttgaatgaa 2260501 gcgggcatta aacggacaga tttgatatat ggactagtta tttttatatc atttaggctt 2260561 ctttgggcta ataaatccac cagagtttac tcaatgtgca ttgctcatga tcgaatctaa 2260621 attgaatctt ttacgcatgt tcatagtcaa aggcgcctca ttcgactatt tttgtaactt 2260681 ttcgcaggaa aaattcgaga atgatgacaa atcccgcata cgacacttaa tacggtagtg 2260741 aacaatagta aattagggtt acatgcagct tgttttccaa tgaaacaaag aaaaagaatc 2260801 atacaaaaag acaggagaaa gcttttgaag tattttaacg ccaaatttac cgcggaagaa 2260861 agagcgatgg aatcactttt ttgtgaaaag gcctcgcaga gcagctcgaa tgttttactg 2260921 aacgactgaa ctctatattt tagcaactga gggagtgaac aatcatgaaa actaaaaatg 2260981 aaccaaaagt tattctggaa ctagcaaagg aatctgatct gccagaattc caaaaaaaat 2261041 tacaagaagc ctttgcgatc gccgtgattg aaacgttcgg tgattgcgaa gatgggccga 2261101 ttccatcgga caatgatgtt caggagtctt tcaatgctcc cggagcagtg gtatatcata 2261161 ttcttcagga tggtaagaat gtcggtggtg cagtagtacg tatcaacagc caaacaaatc 2261221 ataattcgct agatttattc tatgtatctc cagaatatca cagccaaggg attggtcttt 2261281 ctgcttggaa agccattgaa gcacagtatc cggatactgt gctttgggaa accgtgacac 2261341 cttatttcga aaagcgaaat atcaacttct atgtgaataa gtgtggattt catatcgtag 2261401 agttctacaa tgaacatcac tctaatccgc atatgcatcg caatggacgt gaagatgaca 2261461 agcccctact gaatgatgat gactttttca gatttgtaaa gattatgaaa aaaaaggact 2261521 aaacaattga acacggcgag atgccgcaga gagttgctgg taactttttt atatttcatt 2261581 atcagaggaa ggtaataatg atgtttaaaa ggtgttttga tccctgtctc ataaacaggg 2261641 gtcaaaacac ctttgaatca tcggtttctt ttctgacata taccacgccc actagtccct 2261701 caacatagta aaaacatatc atgagttaca aaagctttta ttcaaagcat atgtttattt 2261761 tatttatact tattttcatc atttttcaga attctggaca caaatcgggt acctattaga 2261821 ggccaaggaa ctctacattt cattaagaaa tacgtactca ttgccctgct ttaattaatt 2261881 ttaagccctc gcactatgcc cccccctgaa ttaagtattt gatgtaactt tgaaattaag 2261941 tttatgaaaa tctgtcacaa acccttattt cataacacat catttgtttc agcttccctc 2262001 gcgaataccg gattaatgct cggctttaag atagtcaacc aatctctccg cactgttctt 2262061 aacatcttct tttgaaagat gaagtgtccc atattgtgta aacgcaggaa gaaaacgcat 2262121 tcctatatag ttagcagtga cttgaaacgg tctgataagc tcgctgatcg tgatattata 2262181 ttctccgcct gcttgataat cagattcctg tgcgcctaag gagatagcta agagtagttc 2262241 ttttccatgc aatttagttc ctccagttcc ataagcccag ccatgtgtta acacatcatc 2262301 ttcccattgt ttgagtaacg cgggactgct gtaccaatac attgggaact gaaaaacgat 2262361 acgctcatga tctaacagga gctgctgctc tttttctaca tcaatgataa aattagggta 2262421 ttcaccgtac aggtcatgaa ccgtaatgtc tttctcttgc tttaaacgat tcatccaggt 2262481 tttgttgaca acagacgttt ccaaattagg atgtataacg ataactaatg ttttcattag 2262541 actgattatc ctttctttgc caattagtta ttatttttta cgataatgaa ttgattctaa 2262601 ttttaaaata gcaactttat ttacacctat tttatccttt ttcatgaatt cagggcaact 2262661 aattgggcac caaaatcaat gatgacttaa gacattgttt tgtagaaatc cgatatacag 2262721 aataatccat tatttagaaa atttctacct tttccctcaa tccgagctcg ctcttcatgc 2262781 ggatggccta ttttaaagga ataactgact atgttcatca gttattcctt taaaatacga 2262841 aagtctacga tatttccata tcgatccgct tcaatgtgac agcacccctc aagcagctgt 2262901 tttaattttc cacgtccgcg ttgtaccctt gattttgctc cggagtaaga aatgccgagc 2262961 ttttcactca actctttttg tgataacccc tggaaatcag ttaactcgag cgcctctcga 2263021 tacttttcag gcaaccgttt gatggtcgat cgaatacaca cagttgcttc cttggtgaaa 2263081 ttttcttcct ctgcactgtc attaaaatgt agaacatcag gcaatatttc gcttgttttt 2263141 tttgtacggt aaaaatcaat aatcgtattt ctagtgatcc gataaatcca gctgtcgatc 2263201 ttttgttcat cgatcagatt tgggagatgc acttgtattt tcataaatac gatttgcaag 2263261 aggtcatcaa cgatagattg atcgttaacc ctatgtgaaa tatatgtttt taacggctga 2263321 tgaaattgat cccatagatc ctctatattc atttgaaaaa acctcctata attttgcgtc 2263381 tgctttacat ttgcttcgtc tttttaatcg taacaaagag caaacaattg ttgaatcaat 2263441 tgtattgcag ctgttgccaa aaataatgat aaaggagagg tttgttgtgg agtataccta 2263501 tttagggaga acaggattgc gggtgagccg tttatgttta ggcacgatga attttggagt 2263561 tgatacagac gaaaagactg cgttccgtat catggatgaa gcacttgata acggcattca 2263621 attttttgat actgccaata tttacggctg gggcaaaaac gcaggattga cagagagcat 2263681 cattggaaaa tggtttgcac aaggaggaca gcgccgcgag aaagttgttc tggcgacaaa 2263741 agtatatgaa ccgatttctg atccgaatga cggaccaaat gatatgaggg gcttgtctct 2263801 atacaaaatc agacgtcatc tggaaggatc actgaagcgg cttcagacag atcatatcga 2263861 attgtaccaa atgcatcata tcgataggcg gacaccgtgg gatgagatat gggaagcttt 2263921 tgagactcag gttcgctccg gcaaagtaga ctatattgga tccagtaatt ttgcaggctg 2263981 gcatttagtt aaagcgcaag ctgaagctga aaaacggcga ttcatgggac tcgtcactga 2264041 acagcataag tatagtttat tagaacgaac agctgaaatg gaagtgctgc cggctgcacg 2264101 ggatcttggt ttaggagtag tggcgtggag tccccttgca ggagggcttc ttggcgggaa 2264161 ggcattgaaa agcaatgccg gaactcgtac agcaaaaaga gcagatttaa ttgaaaaaca 2264221 tcgtttgcaa ctcgagaaat tttcagattt atgcaaagaa ctaggagaaa aagaagcaaa 2264281 tgtggctttg gcatgggtgc tggcaaatcc agttttaact gcgccgatca tcggaccacg 2264341 aacggttgag cagctgcgtg atacgataaa agccgttgaa atcagtctgg ataaggagat 2264401 tctccgcatg ttaaatgata tctttcccgg acctggagga gagacacctg aggcatacgc 2264461 ctggtgatac attcattact caatactgac atttttctta aatatttata ctgaactatc 2264521 atattaagaa agacaagagc atgtttgtct cttgtctttt ccacatcgtg ctgaaaatgc 2264581 tggctaaaca tcgacaaaaa tgctgccgct taaaaaagaa ccctaaacaa tagagtaact 2264641 ggaaagacaa ctggcttgat cagcttggga cccctttcag ctgtatttaa atcaatcaaa 2264701 ctaatgattc attggcagtc taaatattat tattgtttct ttacaaaata gtaatagccc 2264761 ctgtaatgat tgctaacaac gtaataacta atgatgtaat tacagcccac ttaacggcaa 2264821 acctttgaaa tgaccccaag tccattttaa gcatgcttac tagcaatact gttgacgcaa 2264881 ccaatggact catcagatga accggctgcc ccattataga agcccttgca atttctactg 2264941 gttctatacc atatgctgag gcagcttctg caaagatagg taccatacca aagtaatatg 2265001 catcatttga taaaacaaaa gtaaacggaa tactagtgag tgctacaata acggggaaaa 2265061 accctcccat tgatgagggg atgatggata ttaatgatcc tgctatggca tccaccatct 2265121 ttgtcccgga taatatacca gcaaatactc ctgctgaaaa taccaataat accacggtta 2265181 tggcattacc agaatgctcg gcgattcgct ccttctgcat ttttacattc ggataattta 2265241 tagtaagggc aagaacaaaa ccaattaaaa ataaaactga cggatgctta gttccaagca 2265301 caataaacac catgatactt ataacgagga ataaattaag atatattaag cgtggccttt 2265361 tcaattgttc gctctccaaa gtagcagcca tataagattg agagctgtcc tttgttatat 2265421 gtctaggctc taattgaacg atgcctattc gattcctctc tttccttccc attagaaaag 2265481 ccagaaatat cacacaagca atacctccaa gcatggtcgg aagtaatggc acaaagaaat 2265541 ctgaaggatc caaacccagc actgaaatcg ctcttgtagc tggtccgccc catggagtca 2265601 ttccgctaac gatactcaac gacagcattg ctaatgtcgc cataaccatg ggattcatac 2265661 caattctttt atacaaaggt aacattgctg agactgttat catataggtt gttgtaccgt 2265721 ccccatctaa agcgataagc attgccaaga cggcagaccc tatcgctatt ttcacagggt 2265781 ctccctttac tatagataaa attttttcta ttagcggatc aaataaacct gcatcaatta 2265841 aaattccgaa aaaaagaata gcaaacaata gcaatgccgc tgaacttgca actgtttgaa 2265901 ttccttctaa aatcatgtcg ccaataccct taccaaaacc tccaataaga gcaaaaacaa 2265961 tgggagtgat ggtcaaggca acaataggcg agactttctt tgtcattatt aatattgtaa 2266021 aaacagttac catcgaaaaa cctaaaatag taagcatatt acacctccaa gaatgcgctt 2266081 tcaaatgact tttgattaac atatcttata cggtgtaata agttaaataa atattttttt 2266141 actgtgtttc aaaaaaaatt ctatcataac tttaaatggt taccatttgt tcacccttta 2266201 aaaaatcaat gaatgcttta acgagtttga ttcctaatga tttttgatcg tacattagcc 2266261 aagtatctct cattagaggc ttacccttag cattatacag ttccattgtg tacaaatgat 2266321 cagattcctg caggcaaatt tctggtgcta tggagtaacc aagaccatgc tttaccatct 2266381 ctttgcaagt ctcttgtcga tccacttcca ttgcaataat gggggcttgt tttagattcg 2266441 tatgcatcca atcttctata atcgttttta aagaagcatc cgttttatat ttgataaaag 2266501 gtaaaaaagg aagttgctct atcgttattg gtttttttga gatgatatgt aatttttccc 2266561 gtgtcagccg ttcctccacc cctttccagc gatggcttcc tctcagtata ccgacttgta 2266621 caataccagc atctaataat ttcatgacat ctgtgctcca gcctgtttgt acactatatt 2266681 ggacattagg atacatagtg gaaaattccc ttaataactt agggagctta tattgagcga 2266741 aattgcttga tacccccagc cttagatgtc cttgcacctc tttgcttaga ttagagatat 2266801 gatctttggt atcttgaagt tcctgtagca ttcttcttgc ataagcaacc aagtgttctc 2266861 cttccgcagt aaaggtaatt cctttatgcc ttttggtgaa taattcaatt ccgaaaatct 2266921 cctcaatctt tttcaaccga taagtgatgg aaggctgtga tgtaaataat cgttctgctg 2266981 tttttgttac actttgttct tcgtgaagaa ttttcaataa aatccaatct ttctcatcca 2267041 ttttcatctt cctttctagt ccttctttca caattataaa agttttttta tcgaatatta 2267101 agaaaactta tattttattt ttattttttt accttctaca ctaaaaaaca taaaaaatac 2267161 tacctttaag atgaggatga tgacgatggt caagacgaat gtaacaatca tgagaggcgg 2267221 aacaagcaaa ggcgtttttt tccacgaatc agccatgcct aacaataaaa acgaatggga 2267281 gccctttttg cttgatgtca tgggaagtcc tgataaaaga caaatagatg gtttgggtgg 2267341 cggtaattcc cttactagta aagtggcaat aataaagaaa gcatatactt cggatattga 2267401 tgttcactat actttcggtc aagtcagcat ttcggaagaa aaggtggact ttaaggggaa 2267461 ctgcggaaat atctccgctg ctgttggtcc atttgctatt gaagaaggac ttgtaaaagc 2267521 gaaagaacca atgactgcgg taaggatcct gaataccaat acgaataaaa tgatcattgc 2267581 ggaagtagaa gtggaagacg gtcaggtcaa atatgacgga gatgttacga tatctggagt 2267641 acctggatct ggatctccaa tctatttaaa ctttcatgat gccgctggtt cagttaccgg 2267701 tcatttattg cctactggaa atagttcgga gtttttagat acaagtcaag gccaaataga 2267761 ggtgtctatt atcgactatg caaatccatt agtttttgtg gaagcgagca gtatcggcct 2267821 ggatggaacg gaacttgcag aagaatttac tgatctacag ttggctcaat ttgaagaatt 2267881 aagatccatt gcggcagaga aatgcggctt tgccagtcga ttttcagcta caaagttatc 2267941 gccggctgtc cccaaactgg ctatagtagc aaaaccagag aaatataaag atagtacagg 2268001 tgcttggcat tcaagcgttg agatggactt acacatcagg atgatgtcca tgcaaaagcc 2268061 acatcaagca ctggctgtca ctggagcgat atgtacaaca agagcccttt cagtggaagg 2268121 tgcaatccct gcaagaatag caaaaaacca ctctacaaag gttcggctag ctcattcttc 2268181 tggtattatt gaaacaatgg tggagcccac tggtataaag atcgtccgta ccgcacgacg 2268241 tattatggac ggaacagttt atacgcatgg agactatcaa atgatgtaga tggactgtgc 2268301 aaaaagcctc ccccctttcc atcgttaata gatggattga atgcgccttc ttgcacagat 2268361 ccattgtaat cttgcatggc tttaaaaaag cctctatatt gttttttatg aaatcgccaa 2268421 ggtcctttca tgtatctgcc tcaagcatga cataatcatt atagagaaaa ttgaatactt 2268481 tttactgcaa ataaaaagat accaacatca ttggtatctt ttagattgag ttcatctgca 2268541 gcggtttctt ttcctcactg cttatttgat tacaaaatta ccgtactcgt ttgaacgaac 2268601 atgaatcggt ccgtttagat tatagttgtt ctccttggcg atagagcgaa gcacgtccac 2268661 acgggcaact gattctctcc attcgtcacg ggtgtcatga ttggccggat tcatcagatc 2268721 gtcatagcgt acgtccaaga atttattcaa ccacttcttc tcgtctattc cgtctttagg 2268781 tgatccgccc gcttttttgt tcgtacgttt aatcaaggca taaaaagagt cagggtcatc 2268841 accatcgcca tgctgaataa ccgtatcgta catcacagct cttgccaatg ctgtttttag 2268901 tccggcatta tccgatcgtt tcatggcagg ctgataatac aaatggtcat ttactttgtc 2268961 ttgagcggcg cgaaattcct tatcatttgc aagcgacttc caggcagaag cgaatccctt 2269021 gagattgctt gtatcatcgc tttcttcctt ggccagacgg cgcaattcag gcagatactt 2269081 tttcagtttg ttattcggaa ctgcctttgt gtatacttcc actacttcca atgcatcccc 2269141 ggtagccgtt gtaaagcctg cccgtccgca tgtatagcct cgcccgtcat ccaatcgctc 2269201 tacatatcca tattggatct ccgttgtgcc gttttcaaag atacttgtca gctgttccgc 2269261 ccggcgcttt tgatctttat tcagtcccgc cgcaaaaacc gtttcgctca tcatcagggt 2269321 aaaaaacatg gtgaaaacaa gtaatgagat cgctgctttt ttccaaaaat ctgctttttg 2269381 catactgatt ttcatttcac ttcccctttc taaatattgt aaatacagac tcagtataca 2269441 tgaagaaact gccctattgt tgaaaataca tcaatttgtc aatattttga atctaaagta 2269501 atatagcttg aatcttactc tattcattgc caatcagcct tagcccctct cactgggaag 2269561 gtcccttgat tttcatactg cttcaacttt cattaacaag atgccataag gctttactct 2269621 attttataat ggaagtgatc atcgaaaatc gttagggagg tgatgtaatg gcaagcaaga 2269681 tgagaatgcc agattccgca acgtcccatg caaagcctac tattgggaag gcgatacttt 2269741 gcatggggta gactttctaa aagatcgccc aagtaagctt ttctgatata gtggctttgc 2269801 accttatttg acataaaaaa ataaggagct ggcagaaatg gcatatgtaa aagcaaccgc 2269861 tattttacct gaaaagctga tatcggaaat tcaaaagtat gttcaaggaa aaacaatata 2269921 tatccctaaa cctgaatcct ctcatcaaaa atggggtgcg tgttcaggaa caagaaagct 2269981 gatcgatgac agaaacgctt ctattaaaaa agcatttaaa aacggcaaaa ccattcatca 2270041 attatctgat gaatatcacc tctctattga aacaataaaa aaaattgtct actctaaata 2270101 aacaaaacgg aagcactgat aaaaaataat cagtgctttt tatatggcga gtttgtttct 2270161 tagttatttc ctgcatatga taccattggc caattgtgta aagttaaggg agatgagaag 2270221 aaaggaaggt cctacaaatg acgataaaca atggaacgtt gcaagtaccc ggcgcgaaca 2270281 tccactatca ggtgcgtggc tctggtccaa tcattctttt ggtccacgga ggaggcggtg 2270341 atgccgacaa gttccatcat gttgccaatc atctggctaa ctggtacacg gttgttactt 2270401 atgatcgccg cggccattcc cgcagcaatc tcgccaatca gattgagggt taccgtgtgg 2270461 aaacacacag tgacgatgct caccgtcttc tagccaaaat caccaataag ccggcctatg 2270521 tatttggaag cagctccggg gctgttatcg ggcttgatct gtgcatacgc catcccgaac 2270581 aagtacatgt catgatccca cacgaaccaa tcttattgca gcttctgcat ggaaatgagc 2270641 tgaaacaagc cgagcaattc atggaagacc ttaagaaaaa tcatcgaagt gaagtcatta 2270701 aattaatgtc aagattagag acagacgaac aatcaaaggc tgtcctgaca aagcggcttc 2270761 tcggcaattc aacgtatttc actgagtatg aaattcaagg aattctcagc tatacattag 2270821 atttcgaagc attaaaaact gtgtttacat cttcaccgat gaagatactc ccagctggcg 2270881 gaagtgcttc tcgggagctt tttccttatc gttgcgcgaa cgccctagcg gaacaattgg 2270941 aaacagaatg ggttgaattc cccggaaatc atacggggta cacaatgtac cataaagaat 2271001 tttctgagag gttacacgac atgttagaaa aagaaaagaa acatacgtgt taaggattga 2271061 ttaaaatttt caaaatagga caggtgaaac taactatgga attggagaag atttcacgaa 2271121 gcgtaaaaag aacttttcac taacgagaac gcaatgtgag atgtttaacc aaagtgatat 2271181 tagggatttc atcgaaaaat aggtttgtac attacgttct cctattgatt atttcctatc 2271241 ttaattccgt attttatacc attagataca actctaaagc ggctcgttat tttgtcctca 2271301 acaacaacca gtgtctaaca tcatgaatct cttttgaaaa tcaccacaaa tgcaggtatg 2271361 gaagacttca tcgcagcaaa aaccatacca actattgttg ttggtatggt tcgtcctaga 2271421 taggccctta agaagagatt ctattgtacg gagtatttag ctaattgcat ttgtaaccga 2271481 cagggccgtc tgaacctgtg tacacatatg tgtcagacac atatccaata ttcacgacac 2271541 cccgggaatc tttccactgg atttggtccc agatattact cgttccatac ttccctgtaa 2271601 cagtcgttcc ataagcgtaa caataataag gaacacggga gccactcgga atggaaagca 2271661 taataggata atttgtacca ggaccgctgc gcatattgac aggcgcaccg ctgcttgttg 2271721 agacagtaaa gtactgaacg gcaagtgcct gactggaaaa aatgaataaa gatgcaatca 2271781 tcacggttaa catactcagc attttcagtt tagtcaatgt catccctctt tcttcaattc 2271841 cttcatttta agaaacgata gaacataggc taccagctgc atttaggaac aaccggaccg 2271901 tctgagcctg tatacatata tgtatcagag acaaatccag gaacgatctc cccgctggca 2271961 agcgtccgct ctgtgtaatt ccaaatattg ctcgttccat actttccagt tacagttgta 2272021 ccggttttgt agcaatagat cgggatgcgg gttccgctcg gaatggtcgt tacaattccc 2272081 caacttgtac ctgggccgct gcgcatgttg acaggagcac cgctgcttgt tgaaaccgta 2272141 taatactgag ccgcaagtgc atggctagaa aaaatgaaca cagatgcaat catcaccgtt 2272201 agcatactta gcctctttaa cttattcacc ttataccctc cccttataaa tgccgtacgt 2272261 ttgactttct tacatccagt taaggattta ctttcagata ccatgccccc tcccctccca 2272321 tatatttatc aatgtaccat aaactagatc tttcaaaagt ggaattattc ctatgttttc 2272381 gacaattaag gatacaaaat aaatggtagt caggcttgat attgatggtg tgttacattt 2272441 ggctcttaat catttgtcca gtcggtaatc acgattgaca atcaggaaaa aggacatgga 2272501 tcaagcggct tcgtttccac caattaactc aatcagtgta ctgcttcctt gtatccacgc 2272561 ttcttctcga ttcatagata ctccaccttt ttcaccaatc aaaaacggac accatacaaa 2272621 tcagcgtaaa tgctgcaagt tcagtgtccg caacctatta tgactttgct ttcttttacc 2272681 agggcgtgta aaaatgatta ggtacgttat caaacgttat tctatgattt tgcgagtcaa 2272741 aaaatcataa cattttatat atttcaatca gattatgatc tggatctctg aagtgagcaa 2272801 ctcgggcact ccattccttg cgatcatgcg gtttattctc acatttaact cctttttcgt 2272861 gtaaatcgtc atacgtttta tcaacatctt ctaccttaaa ctgaagcaaa aattttgatt 2272921 gagcttctcc ttccaaggac tttttttcct ctccaacgat ttcagccatc gtttctcgag 2272981 ataaaagctc tattttcgtt tccccattat caaagagtgc atattccatt tcattctcta 2273041 accaacttat tggaagtcct aatgaatctt tataaaactc gacgcttttc ttaaaatcat 2273101 tcaccaacag tctaatttgt aacagcttca tatcgagtgc ctcctataaa accatacttt 2273161 tactggtcat ccaatttaat gataccaaag aaacctgaca gcactatgtc aagtttccat 2273221 acttcaccct tatttcagat ttaagtgcag tttagtccat gtcataagaa cgagcaaaaa 2273281 cagcgattct taaaacaaaa aatgataccg agtgtatttt ctgtatgctt caacttcatt 2273341 tcgggaaatg taacgttgat aaaaggaggt tacatcaata tggatcatca aacattggca 2273401 gctcatgagg ctgttgactt acatgaaatc gtgaacttta aaacactttg tatagcgaaa 2273461 tcaaagttaa tgcaagggct tgtgtttgac caagaactga aggacttgat ggaaaaagat 2273521 gtacagcaat ccattcaaga ccttactgaa ttacaagcgg tttatgagcg tgcctcattt 2273581 caggcccctg tccctcaaag ccgcccaacg ccaatcatca attgaaaggg aggtaagcct 2273641 ctttgaataa tgatcattta gaccccatta attcgctgaa tgtgcctgaa ctagcagaca 2273701 ctacattcgc gatggatttt cttatacgag ctaaggaagg cgtaaggaat actgctgtag 2273761 ctttgacaga aaccgcttca ccagatgtaa gagcactgct tcggaaacag ctgatgcaag 2273821 gaattgcgat gcaccaagag attacggaac tgatgatcag caaaaagtgg ttccatccat 2273881 atgagctgag cgaacagtat aagctggatc agctctctgc aaaaaacacg atcatggtcg 2273941 gcaatatgaa cctctttcct gatgaaacaa atcgcaaagg gatgtttgac cggacacctg 2274001 atgaacacta acactggagg ttttacagca tgaaggcagt aacgtatcaa ggcattaaaa 2274061 atgttgttgt caaagatgtc cccgatccaa agattgaaaa atccgatgac atgattatca 2274121 aagtcaccag tacagccatt tgcggatcag atttacattt aatccatgga ttcattccga 2274181 atatgcaaga agactatgtc atcggccatg aaccgatggg aatcgtcgaa gaagttggtt 2274241 ctggggtgac taaactaaaa aagggagatc gggtaattat tccctttaat atagcatgcg 2274301 gggaatgctt tttttgtaaa aaccagctgg aaagccaatg tgatcagtct aatgacaatg 2274361 gggaaatggg tgcttatttc ggctattcag ggcaaactgg cggttatcca ggcgggcaag 2274421 ctgaatattt aagagtgccg tttgcgaatt ttacccattt taaaatccct gaatcttgtg 2274481 aggaacccga tgagaaatta agcgtgattg ccgatgccat gaccaccggc ttttggagtg 2274541 tggataatgc cggcgtaaaa aaaggcgata cagttatcgt tctcggctgc ggaccagtcg 2274601 gcctgtttgc tcaaaagttt tgttggctaa aaggcgcaaa acgcgtcata gcagttgact 2274661 atgtaaacta tcgcttacag catgcgaaac gtacaaacaa agtagaaatc gttaattttg 2274721 aagaccatga gaatacaggg aattatttaa aggaaatcac gaaaggcgga gcggatgtag 2274781 tcattgacgc tgttgggatg gatggtaaaa tgagcgatct cgagttcctt gccagcggct 2274841 taaagcttca tggcggaacg atgagtgcat tggtcattgc ttcccaagct gttcgcaaag 2274901 gaggaaccat acaaattaca ggtgtgtatg gaggcagata taacggtttt ccgttaggag 2274961 atattatgca gcgaaacgtc aatatacgct ctggacaggc tccagtgatc cactatatgc 2275021 cgtacatgtt tgaactagta tcgacaggca aaattgatcc gggagatgtt gtcagccatg 2275081 tcctgccgct tagtgaagcc aagcatggct atgacatttt tgattcaaaa atggatgatt 2275141 gtatcaaagt tgtgttaaag ccttaaaaaa cggaggttac agaaatggaa tacgccttac 2275201 acgaagtgct tgaggttcag gaaatgactg catttaagac actttgtttg acgaaatcta 2275261 aaacaatgaa agcactggta tctgatccga agctgaaaga aatcatgcag caagatgttg 2275321 atatcaccac acgccagttg caggaatttg cctctatttt atctaatgca aagcaagaat 2275381 gaggagatga ataaatcatg aatcctatca tagaatatct gactggcatg aatgttctaa 2275441 cagaccaaat cattgctatg gacttattaa tttcagcaaa gaacggagtc agaaattatg 2275501 cgatggcagc cactgaagcc ggaacgcctg aagtaaaaga ggtccttatc cgccatttgg 2275561 aagaagcact cgatatgcac gaacaactct caagctatat gatggaaaaa ggctggtacc 2275621 atccttggaa ccctgacgaa caagtcaagc tgaatttaaa aaatattgat acagccattc 2275681 aattgccaac cctttaacat acaatgactg atttgctgag gaacagtatt gattggccac 2275741 aactgttcct cagcttcaaa atgagcactg tttgttcggg tcctatgacc gtaaatagat 2275801 taaccgcttt tctccatctg atctccgata atgtttgcaa attctccaat ccaaataagg 2275861 aatcgtaacc acctcttttt atgcgatctc ttgatggaga aaacaggcca gaaacaaaat 2275921 ccttcgtttt tgacctgccc tcttcacacg caaagaatgc taccttcttt gctccactga 2275981 tccgtgaaga ctttccgttt taggcctgct tttgagcttt gcctcatttt cacgcaattt 2276041 cccatcataa tctttaattt ttgtgtctaa tctcttaatt gtttcatcaa tttctttccg 2276101 cttctctatc agccgctgtc gttcgtcagc caggatattt tttcgagctt ctaccgtacg 2276161 gtcaccttcg gtaaataatg ttgtatattc aattagcgct tctatcgata gtcccgcatt 2276221 tcgcatgcat ttaatgaatt caatccattt gatatcttct tcatcatagt cgcgaatgcc 2276281 gctgtctttt cgttttacag gcgggattaa tcctacacgt tcgtaatatc ggagtgttgc 2276341 ggctgtcagg ccaaactgct ttgccacctg agcaatattc atgatcttca cctctctatc 2276401 ctgtatgttg tgaaggtaac acttaaagtt aactttaagt caagctcaaa acaagtggtt 2276461 agctgctgaa tctgggttta tatattcggg acttgcctta aagcacactt taaactctat 2276521 acttctccat gcactaaaaa cagtgtagtt ggagggattg ctgaatggca aataaacaca 2276581 ctgccggaag agaacaatta ggagaatttg cgccaaagtt tgctgaactt catgatgatg 2276641 ttctattcgg tgacatttgg gcaagagaag aagaactttc atcccgggat cgcagcatga 2276701 ttacagtttc tgcattaatt actgactgtt tctcagctta taaatcaggt tcattttaaa 2276761 tggttttttt aaaaaaccct tgccttaaag cagactttaa ggtttatcgt tatgttgaag 2276821 acaccataaa acataaataa gtgcatgttt ttatttacaa cacttatgat gaagaaagga 2276881 taggttcgta tgtgtaatca acatcaaacc cgtgtattaa gcgtgtcaca tgcaaaagcc 2276941 aaatttgaac aaacgacgat tgagcgaaga ggattacggc cgcacgatgt cttaatcgat 2277001 attaaattca gcggcatttg ccattcagac attcatagcg cttttgatga atggggcggt 2277061 ggcatcttcc caatggtgcc tggacatgaa atagccggtg ttgtaacagc cgttggaaca 2277121 aaagtcacca agttggctgt cggggaccgc gttggtgtcg gctgttttgt tgactcttgc 2277181 ggagaatgcg aatactgtct caacgcagag gaacaattct gcacgaaggg tgttgttcaa 2277241 acgtataact cagtagacta cgacggaaac cccacttatg gcgggtacag ccaaaaaatc 2277301 gttgtcactg acagatttgt tgttcgcata ccagatcgtt tggaaatgga tgttgccagt 2277361 ccgctgttgt gtgcaggtat cacaacgtat tccccgctga aacactggaa tgttggccct 2277421 ggtaaaaagg ttgcgattgt aggcgtaggt ggccttggac atttggcaat tcaatttgca 2277481 catgcgatgg gtgcagaagt aaccgtcctg agccgttcca tgaataagaa agaggaagct 2277541 ctggaactcg gtgcaaatca ttactttgca acaagtgacc cagccacatt cactgcattg 2277601 gccgggcgtt ttgacgtgat cttaaatacg gtatcggcaa atctcgatgt agatgcctat 2277661 ttatcaatgc ttcgtataga cgggacactt gtaagcgttg gagctcctgc caagccggac 2277721 acatacagtg tgttttccct aatcatgggg cgccgcagca ttgcaggttc tctagtcggc 2277781 ggaattcaag aaactcaaga gatgctggat ttcgcagctg agcatggcat cgaacctaaa 2277841 atcgaagtca tcggagctga ccaagtggac gaggcatacg aacgtatcct ccgaagcgat 2277901 gtccgttatc gatttgtgat tgatatttcc acattgtaat aggttagtcc ttatatgggc 2277961 tgccgctttt attgaaactc acgaaaaatg atctctttaa gcaaatattt tgaaggccgg 2278021 tcaatcttcc tgttattcta tgaatagaga gttattagga gggtttttta tgagcaaaaa 2278081 aattgcagtt cttgttacag accaattcga agacatcgaa tatacaagtc cggtaaaagc 2278141 atacgaagaa gctggctaca gtgttgtggc tatcgatttg gaagccggca aagaagttac 2278201 cggtaagcat ggcgagaaag taaagattga caaagccatc tctgatgtgg atgcaagtga 2278261 ctttgatgca cttttaattc ctgggggatt ctctccggat ttgcttcgtg cagatgaccg 2278321 tccgggtgaa ttcgcaaaag catttgtcga aaacaaaaaa cctgttttcg caatttgcca 2278381 cggcccgcaa gtactgattg atacggatct tctaaaaggc aaagatatca caggctaccg 2278441 cagcatccgc aaagatttaa tcaatgccgg tgcaaactac aaagatgcag aagtagtcgt 2278501 cagccacaac attgtcacaa gcagaacacc tgatgatttg gaagcattta accgcgaatc 2278561 tttaaacttg ttaaaataac aagaaggcac agactgttcg ggtctgtgcc ttttttaaaa 2278621 ttaagactcc ttcgttacat tctgaaagac agcagtcgcg tcccacacat tcaagccaaa 2278681 ttggccttct gaaaatacgg aatcatgtgc atcaatcaca agacgatcat ctaaatagat 2278741 tttaaagcga tcgccctcgg cctctgtttt cagatgatac tttttattaa cgtctatcgg 2278801 tgttttgtat tcagcaatga cagaagcagc accgttctca aatttaaaga atttcactag 2278861 gtcatgcttc gcatccacat tggcaaggta accgtttttg gcatctttgt cagagcgaaa 2278921 cattagtgct cctgcccctc ttccgtttcc atccttaatg gtgatatcag attcataagt 2278981 gaagtctgac ccggatgctg aagacaagat aaaggaatcg ccgtccgacc tcccttgttt 2279041 cccctcaatt gtgtctgccc acgtgccatt tacagtcgtc cagccagtca tattggacat 2279101 aaaaggtgtc gttccccata ccttttttaa agggtgtatc gttaaagatt ttacctttac 2279161 accgccattt gcagcatata attcaagccc tttgcttgat cggtctggga gaataatatc 2279221 cgttatgacc tgctttccgt cattcccaaa tacttcaacc gaggagcggt caacaaaaat 2279281 gcgcaactta accttcccat ttaccggctt caacggggct gtttcttttc cggtgttaaa 2279341 ggccggatta aaggtgtcgt tgcctgactc gctccggtca acgaacaatt tggcgttcct 2279401 tcggtcatag ccgaccttcg taaattgatt ttcacctgtt cggaccttaa aaccaaattc 2279461 agcagctgaa ccagggctta ctttaaattc tgcatttatt tcataggcat ctccagattg 2279521 ccccgctaac acattatgac ttgcaggcga tatggtcaga ttcttccact tcttagaggt 2279581 tccgcgaatg gtttccagct ctttcaccgg tgtttggacc actctaaccc cttcggtaaa 2279641 cgctttcaat tttaactctc ttggaatgga cgttgcactt ctccatgggg atgtcggaac 2279701 atcattcgca tattgccaat tgctcatcca ccctaaccat agccggcggc tgtctgtgga 2279761 tggaatatca gaccaggata cagccgcata aaagtctctg ccgtaatccg tccagagaac 2279821 tttgtttggc gggttttcat ttttaaaatg agttccatca aagtccccta caaaatattg 2279881 catgcctgat cctcccgaga ccgctccgtt tccgacactg acctgcatga cccatttctt 2279941 ttgattcgga ttgccgtcta ccggaagctc aaataaatcc gggcattccc atactccccc 2280001 gtggcttcct tgatcctgtc caaattcact tgcatacgtc cactgcttca gattttttga 2280061 tgtataaatg aggattcggt caccggccgc aagcaccatc acccactttt tttctttctc 2280121 ataccaaaag acttttggat cgcgaaaatc ttttttaccc gggtttggaa tgacagggtt 2280181 gccagcgtac ttcgtccatg ttcttccttt gtcgttgcta taggcaatac tttgcacttg 2280241 atggccttcc cgatcctgtg tataaatggc cacaagcggc ttctctttgc ctgtttgaaa 2280301 accgcttgtg ttatttttat ctacaactgc gcttccagaa aagatcgtgc ctttttcatc 2280361 cggatacagc gcaacaggaa ggtgttccca tgtaaccaaa tctttgctga cggcatgccc 2280421 ccaatgcatg ggcccccact gaagcccgta tggatggtat tgatagaaca agtgatattc 2280481 cccagcataa tataccattc cgtttgggtc attcatccag tttgcctccg gtgtgaagtg 2280541 atattgagga cggtaatcct catcatagta gcttgaatcg gctgcatctg ccgaaaatgc 2280601 catagtcaac agcagggtga acatgatcat gacttgaatc agtctctttt tcatttgttc 2280661 cttcgctcct ctcttcatgt ttgaacactt tcaaaagaga ctgctgcgca agctggtccg 2280721 tttctggcaa ttctcctctg tttcactgtt atccgaatga tttatatatg aaaagactgc 2280781 tgcagtttct ctctctttcc ttcacacacc ttatgctaag aatccagccc aatacccgag 2280841 aatcccgatg acaaagatgc cgcaaataat gagaagtgga ttcacccctt tgcgaagcat 2280901 ccatgccacc aataacgtta atccgagagg cagcgccccc ggcataatgc tatctagcac 2280961 gttttgtacc gtttgaacat ctacttttcc gctttcatcc ttaatcctgg atacaacgat 2281021 tggaatgttg atggtggtcc atttggacac gagagccccc ataacaaata acccgagaat 2281081 cgaagcgccc tctgtaagct tttgaatgcg attccccgct aaatcctgaa gaatctccat 2281141 tcctttcaca tagccatact ttaatccgta atattttgtg cttaatctta tggcattcag 2281201 caagaaaaag aatagcaaag gaccggcaat gtttcctcct aaagcaaggg aggctcctag 2281261 cgcagctaag acaggacgaa tcgttcccca aaaaattgga tcgcctacgc ccgctattgg 2281321 tcccatcaaa ccgattttca ttccgcttat cgcttttccg tcaattcctt tattgttcgc 2281381 catttcttct tccatggctg ccgtcacgcc aaatataggc gctgtcagcc acggatgtgt 2281441 attaaaccat tccaaatgcc gctgtaaggc ttcgtttctt ttcgctccgg gaccgtacaa 2281501 ttttttgatc gccggtatca tgacataaca atatcccatt gcctgcacac gttcgaagtt 2281561 aaaggaaccg agtaaaaaat ttgaacgaat aaacatgctg aaaatttctt tcttcgttaa 2281621 tcgtttttct ttctccattt tttcttcccc ctcatcgttt aggcatcaag atcatcatca 2281681 tcgtcatcat aaacagcaac actgccactg tctgatgcgg ccgcgactgc tccgtgagcg 2281741 ctttgttttt gcatcacctg ctggtataaa agcgccagac agagaccaag ggctccaaat 2281801 cccactaagt taaaatcggt aaacgccgct aataagaaac caatatagaa aaatggcttt 2281861 aaataaggaa tattcatcat attgatcacc atggcatacc cgacaaccac aataatgcct 2281921 ccgcctattt gcagtccttt tgtaatgaca tcaggaatat ttcccaggaa cgcctgaaca 2281981 gcgctgacac taattaaagc aacaatcaat gtaggaatca tgacgcgcaa agcttgaaac 2282041 accatcgcgg taatatgcat aatttcaatt ccttttatat ttcccgcttt tgcatattga 2282101 tcagcgcggt ggatgaaaaa gacagtgatc gtccgaacaa aaatcgtcag cgcctgaccc 2282161 gcagctgcta aagcaacagc gacagcaatc ccttcgccaa ttccttgatc agcggtaata 2282221 actaaaatgg ttgagatgac agaggcgatc gctgtatcag gtgccatggc aagcccgacg 2282281 ttcatccagc cgagcgccat cagctccagt gtgcctccaa gaataattcc cgtttttaag 2282341 tccccgagca ccaagccaac caacgtacag gccactagcg gccggtgtgt ctgcccttca 2282401 tccaatacac ttgcgattcc ggtgattgct gcaatgatta acaacaaaat aatttgtaat 2282461 gaagacatat tctcatcccc ttgattattt tgttacgttc cgtaaaatct gtacaaaatc 2282521 ctcactggca tctgaaggca gctgcctcaa ttccagtttc acgcccttgt cacttaatgt 2282581 ttcaaatgcc tttatatctt gttctgtgac actgactgat tttgtgattt gcctgcgatg 2282641 attttcaaaa cgcattcccc cgacgtttac ggttttgatc ggtacacctg cttctataag 2282701 agatacaata tcggacggat tttcaaacaa gagcattgcc gttacccctt cgtagcgcgg 2282761 actatgaaat gcttttgcca ttttagaaac cgagacggca ctcgccttta catttgaagg 2282821 cgcaacagaa aggatcagcg tttttctcat ttcgtcctga gcaatatcgt cggagacaac 2282881 gatgattcgg tcggctgcat ggacttttat ccaccttgtc aggatttggc cgtgaataaa 2282941 gcggtcatca attcttgcta acacaatgtt catcataatt catcctctct tgtatcttga 2283001 ttggctgttt ttactttttc taaatgttca ctgcacactt gaaagctttg ctgactcatt 2283061 gcttttaagt tgttcagcaa atctttgaga gccagatgtt ctctcaggct taatacctcc 2283121 agcagaatcg gcaggtttac gccggcagcc atatccattc tttgatcctc agcaataaag 2283181 gaagctgccg cgttatatgg cgtccctcca aaaatatcga ctaaaaaaag cacttcatgt 2283241 tcttccggga tatccttgag cgcctgatga tatttttctt gcagcgtttg tattccttcc 2283301 cctttgaaaa acggcactgc aatcaggtta ttttcttcac cgaatatcat ccctgaagac 2283361 tcttttaatg ctatgggaaa atctccatga ccgctgataa taactgaaat catatctatt 2283421 gctcctttcc tgttttgtac atccatatat aatgcaagga tcgtgccaac acagttgtgt 2283481 taagcgtttt cattgttatt tcagccaata gcaatttgtt gttgaaacac ttaaaacgaa 2283541 aaaaataaac ctgtattaaa atggtgttcc atttaataca ggttcatatg aaaaaactgt 2283601 ttttaaaaca gctggccatg cacttcttca gcaaatatgg cggctataaa taatttttca 2283661 tcatcactta tgcgaagtcc gagcttttct tcataagggg ctaatgttcg ctctgtcacg 2283721 tacaccattt ccttcagctg atcattgatc tcttcttcct ctgagaaagc gatcggattc 2283781 tgcttaatta ccctttcaaa ggcgaaagcc gtgtgcataa tgactttgat caaaaccgca 2283841 ttattgaaaa tgacccccag ctcatcctga acggtttgca gccactccaa taacatgtcg 2283901 atcacatggt ggggattcaa gaagacaagg tattttttca ggctatcctc gcaaagctcc 2283961 ctgacaataa tatttgcttc gttcaatcca ttgctcaagg agatgcttcc ttttgtaatc 2284021 gcctgttgaa tcagcttctc tccctcccct tcaattaaca cttctaaaga tacatgcgga 2284081 gcattgattt tagggtcttt cgttccgact gtcgcaagga tttcatactc tttttcgatt 2284141 tcttttatgc tgttggccag cttaatcgat gatacggtca atatgtgaat gggggtatcg 2284201 gaggccttgt ttacgatcgt ggttagaatg tcttccagct ttttggccgt tccgctaccc 2284261 gtcgtgcaga tggataccaa tgccttcttt ttgccggatg ccgctggctg acgctcccac 2284321 aactcgataa aatccttcgt gaccgattga tagatcgcat gcaaatttaa attcaaatag 2284381 ttgacctttc tgacagcatc cagcaccatt gaagtcgtaa cattgctgat cgttttaata 2284441 gaaatgcctg tcttttcctc cagcctgctt tccagcattg caagcgaccc catatctacc 2284501 agcattaaaa caccttcacc ttcatcaacc tgtttcattt tttctgctac gcattcaaga 2284561 atgtccgaag gtgaaacagt aagcggcatg tcaactgctg caatcggcgt actccctagc 2284621 agttctgtcg cgacttcaac cattgaactc gccgtgctgt ttccatgagc tgccacgata 2284681 ataccgactc ttttgttctc ctttaacgat ttgatggaat gaattaacat cgttaagtag 2284741 atgacttcta tttcaggaat agccacttta aaatattcct gaattttatc tttaaaaatc 2284801 atcgccaccc gatattcttt cacatgggta tcacgaattt catctgtctc ctgtgtattc 2284861 aaaacatcaa tttgctttcc tcgctttaaa aatgcgtcaa tatgcatact caagaaataa 2284921 ataaacttac ggtcaaatgt gcaatccagc tcatgttcag ctatttcttt taactgtttt 2284981 gtcatttgaa tcacatcgtc ttcaacgaat gtcagcaggt tgtctttttg aaaagcttga 2285041 tgatgaaaaa aacttctgac atgcaaatgg acatcagtca agatgtactg gttaatatcc 2285101 tttttggata aaccttcttt cataagcgtt ttcacttttt cctcaatcaa atgatataag 2285161 ttaaatgaga ggtcttcgtc aatttttgtt gtttcatctt ctacaatcgg agagataatc 2285221 gttgtaatat tgacatattc agaaatggct ttgcttcttt gcatgttttt gctgctggac 2285281 atccattctt gcttgatttc atcaggcaga tcgcgaacag tcagttcaat aacttcattt 2285341 ctgtcaaggt tatgcaaaaa tccgtgtgcg caaactaact gaacatttga tttcagctgt 2285401 ccgacattcc caaatttcgc agagtgaata agcgcattat agacatcgat atgcacactc 2285461 agattcttct taattcgctc tgcttctttc cctaataaaa acgtcgtcag atccactctt 2285521 tcattaagcg atcgttcttc aagcgaagga atatgaatgg tcattgggat tcttcgcaaa 2285581 aacgttttca atagtgcaga actcggattt tctgtagtcg cacaaataaa caatacgttc 2285641 gatgttcgtt tatgttcaga ttctccaagc ctgttataag aaccgctgtc aataaaataa 2285701 aacagcattt cttgtccctc gggagggaga cggtggattt catccataaa aagaatgccc 2285761 ccattggcct gttcgactaa acccgcctta tcctcggcag cacctgtaaa tgaacctttt 2285821 ttgtgtccga ataattgaga aagcaataat tgagggttgt tgtagtagtc tgcacagtta 2285881 aatgtaataa atggtgcgcc ggccttcaat atgtcagagt aaatggcaaa ctggtaaatt 2285941 cggttcgcaa aaagggattt accggaacca gtcggcccta ggaggagcat atgcagaccg 2286001 ttcggcggat aaaagacagc tgcttttgcc tgggagatcg ctttcttcaa actccctttt 2286061 gcccctatca taagctctag gggattcgtg gaaatgtgtt gatgattttg ctttgaattt 2286121 ccggaaaacg cctgaaggtc tttcacttcc atcatctctg tatcccattt cttgttgaat 2286181 aatttttctg ctatctcgac tgggatgtat cttacaggaa atgttttaat tttgatgacc 2286241 tttttggacc ggacgagatt gttcaattca aagctgacat tggaccgctc cattttcagc 2286301 tgctcggcaa tctcctttgc tgaattccct tgtattttta aaagatgatc taaggttgaa 2286361 tcatgaaaat tatgcttgag ctgatggtat attttatcta ttcttctcac gtctatcatc 2286421 ctttgtcctt attagataag ccattaacaa gaatatttcg aaactttata gtccgcgttg 2286481 agatttacac gtttaaaaag gtctctatag cagattgaca aagctggctt ttatgcgtat 2286541 atgtttacat gttgaatcat ttgcacctca tattagtatg atagatgctc agttctggag 2286601 ggccagtccc cttcaaaagt aataatcagt aaacagttta tcattctcgg ggaatgtaat 2286661 gatgtcaaaa taatcaatga caaaaaatga atcttataga tcatgacaaa ttacccaaat 2286721 ataacccctt aagttcgttc acaactaaaa agacggacac tctatgtgac cgccacagta 2286781 ttacaatttg caaaacttcg tcatttttgc aatccacatt ggaggttaag gaatctgtaa 2286841 gcttaaaaac tttatctccg atcctatcga tttgatcccc ctgccggcct caatcatagt 2286901 gggtatgcaa ttatacaaat cgttaccgat taaaactagc ctgtcagatt gtccaaatga 2286961 ctttcctgtt ttactctgct attcaggtag aatcacgagt gaaaaataga gccacaagac 2287021 atgtaacagc acttaaaata gttttaaaat ttaaaaataa aagtatctat tcttttaaat 2287081 gttataatat ccgataaaac tttactcatc tttttattac tggaggaaaa taaaattgat 2287141 aggcaattct agcaaagaca attttggcca gcaacagaaa ttgtctagag gccttaaaaa 2287201 caggcatata caattaatgg cgattggagg tgcaatcggt acaggtttat ttttaggttc 2287261 aggtaaatcc atccattttg caggaccatc cattttattt gcttacttga tcaccggcgt 2287321 attttgcttt ttcattatgc gttcgctcgg agaactgctc ttatcaaatg cgggatacca 2287381 ctcttttgtt gattttgtaa gggactattt aggaaacatg gcagcattta tcactgggtg 2287441 gacctactgg ttctgttgga tttccctcgc gatggctgat ttaacggcgg tcggcattta 2287501 tacgcaatat tggcttcccg atgtgcctca atggctgccg ggtcttcttg cgcttattat 2287561 cctgctgatc atgaaccttg ccaccgttaa acttttcgga gaattagaat tttggtttgc 2287621 attgatcaaa gtcattgcca tactggctct gatcgtaact ggtattctcc tgattgcgaa 2287681 aggtttttcc gcagcttccg gccctgccag cctcaacaac ctttggagcc acggcggcat 2287741 gttcccaaat ggatggcatg ggtttatcct atctttccaa atggtcgtct tcgctttcgt 2287801 gggtattgaa cttgttggac tgacagcagg tgaaacagaa aatccccaaa aagtgatccc 2287861 taaagccatc aatcaaattc ctgtccggat tttacttttt tatgttggcg cacttttcgt 2287921 gattatgtgt atctatcctt ggaatgtgtt gaatccaaac gaaagcccat ttgttcaggt 2287981 cttctctgca gtaggcatcg ttgtggctgc cagtttgatc aattttgttg tattaacatc 2288041 agccgcatca gctgcaaata gcgctttatt cagcacaagc cgaatggtct attcacttgc 2288101 aaaggatcat cacgcacctg gactattaaa gaaattaact tcttctaacg tgccaagcaa 2288161 tgcgctgttc ttttcatcca tcgccattct gattggcgtt agtctgaatt atttaatgcc 2288221 cgagcaagtc ttcacgctga ttacaagtgt ttcaacaata tgcttcattt ttatttgggg 2288281 catcacggtg atttgccatt tgaaatatcg aaaaacaagg cagcatgaag cgaaagcaaa 2288341 caaatttaaa atgccttttt acccattatc caactattta acacttgcat ttctcgcgtt 2288401 cattcttgtc atattggcac tggcgaatga tacacgtatt gctttgtttg tcaccccggt 2288461 ctggtttgtt ttattgatta ttttgtataa ggtgcaaacc cgcagaggac ataaggtgaa 2288521 ataaaaaaaa gacaagggat actcactccc ttgtcttttt atatgtgtca aacactaaat 2288581 taaactttgg tttcaaattt cattcacttc atttaagtgt taactcaaac cagttttgat 2288641 gccgaaacct actaatatta ttccggtaat tttttgaaac actttctgga acttcgagtt 2288701 tttcatccat ttttttgcgt aatcaataat ataaacaaga aacaggaacc acaacaccgc 2288761 taataaggtt aggattgaag ctaaaatgat gagctgctgg tttatatttc cgttcaaatt 2288821 gataaattgg ggcatgattg taacatacac caaaacagtt ttaggattga gaatgttact 2288881 gagtgatccc tgcataaagg aagttttata ataacgtttc ggagaacttg ccatattttt 2288941 tgcttgggat tgcatgtcat ctaacgaaaa catactttta gcaaaaaaac tttttacacc 2289001 taaataaatt aagtatgccg ctcccaaata tttgatcgtt gtgaaaagaa tcactgactt 2289061 tgcgattacc actgataatc ctaaaatggc aatcaccgtc caaaaggaaa gtcctgtcgc 2289121 caatccgaga atgttataac ggccggcttt cggaccatac ctaagcgtat ttttcatcac 2289181 aagcatcgta tctgcccccg gtatgataac catcatggca gcgatcggta tgtatgcgag 2289241 taagctgtgc attgttctct ccccctttaa aaatcccctc aatcatatag tgactacaaa 2289301 agtaactact tataaaagtg tatcaatgcg tttggaataa atcaatatga tttgttaaaa 2289361 tagcgattac taaggcagcg attgctcttt atattggagg atatatgaaa gaaaatatgt 2289421 tagacatttt aaaaaacctc aattttacag aatatgaatc gaaagcgtat ttagcattat 2289481 tgcaagaatc acctttaaca ggctatgccg ttgccaaaaa atccggagtg ccccgttcta 2289541 aaatttatga agtattggaa agtcttgtca taaggggaga tgtttttgtc agtcatggaa 2289601 atacgcctca gtatgttcca gtccccgcaa aagaactgat taaaaaccgc cggctcaaag 2289661 cggaagagca ttttgatcag gctgagaaat attttgaaaa gttcgagcag accgcaaatg 2289721 accgggaaaa catctggaat atcaccggcc gcagtgaaat tcttgaaaag gtgaaggctt 2289781 gtatcttatc tgccaaaaaa agaatcctct tagaaatatg gaaagaggat tttaaggaga 2289841 tagaagcaga gctcaaacag gcggcagaac aaggcgttat tgtcaccatt attgcgtacg 2289901 gagacatcgt atctgatttt gccaatgttt accttcatga tatgagcagt gaaattacag 2289961 aagagtatga cggacggtgg cttgtctata gcggagatga ttcagaagta gtagcgggca 2290021 ttgtctcact tggcaacgac agccgtgctg catggacgat gcatgtaggg ttagtcatgc 2290081 ctattactga agtgatcatt catgatctgt acctcatgga aattctgaaa aagcatagag 2290141 agcttttaga agagagcttc gggaaaaatc tcatccagtt gcgccgtaaa ttttctattc 2290201 actcagattt caaaaaacat tatttggaat aatgtttgtc atctcttacc ccaaaaacaa 2290261 ggcttgtaca aaacaagcct tgttttttta tgcataaacc ccccatgctg atttacttct 2290321 ctcttttaaa aaatgtgatt ctgcgcaaac tatttttcag cctgccgcgt ctatcctagg 2290381 taacagccta cgatatacgt atattcaaaa aggagccctt tattgcaatg aagaaaaaac 2290441 aaacaacaaa agcgttgctt gtcacatgca taactgacca taagcaagat ttctacaggt 2290501 tggctttcag ttatgtgaaa aatcaagatg acgcattaga tattgttcag gaatctataa 2290561 aaaaagcgct gagctcagtt gaaacggtca ggaaccctga gacgataaaa agctggtttt 2290621 ataaaatttt agtacggaca gccattgact ttttgcgcaa acaaaaaaag ataagagtga 2290681 tggacgacga aacgatagaa tttttaagca aaggaaagga agaccattac aaggatactg 2290741 atctccatga agcgcttgac gaattgccgt accgctataa aaccattatt attttacgtt 2290801 tttttgaaga cctcaaatta gaagaaattg cggaaattac aggagaaaac acgaataccg 2290861 tcaaaacgcg cctatacaga gcattgaagc tgatgcgcat tcagttgacg aaggaggatc 2290921 tttcttaatg gataagagat tacagcaatt aagagaagaa tataaaaatg ttcagattcc 2290981 taaagaattg gatatcattg ttgaaaaagc ccttcagcaa gaaccaaaaa agaaaagaat 2291041 cgttatgtgg ccgacatcag cagcaatcgc tgcagctatt ttattcactg cgcttgttaa 2291101 tatcaacccg gacgccgctc aggctatgtc aaagatccct gtcatcggca aaatcgtcaa 2291161 agcgatcacc tttattgaaa tcaaagagga aaaagaccaa tcaagcattg atgtcaaaac 2291221 acctgctttg tccgggcttt ctaataaaga gcttgaaaac agcattaacg agaaatactt 2291281 gaaagaaagc cagcagctgt ataaagagtt tatacagtcc acatccaaaa acaaaaaagg 2291341 gcatctcagc atctacagtg attacgagac ggtcacagac acgccagatt tactctctat 2291401 ccggcgcaat attgaaacaa cacaagcatc ttcctacaca caaagccgtt atattacaat 2291461 tgacaaaaag aatgatattt tacttacatt aaaaagctta ttcaaagatg agcgctatat 2291521 caaagtcatc agtcaaaaca tcaaagaaca aatgaaacag caaatgaagg aagatccaaa 2291581 taaaatatat tggctcactg acgaagatgc agaaccgttc aaaacgattc ttcctgatca 2291641 gacgttttac attactgaag accataaact tgtgatctca tttgacgaat atgaagtcgc 2291701 ccccggctat atgggcgtta cagagtttac aattccaacc ggcgtcattt caaacttgct 2291761 cgtgggagaa cgttatattc gataaaataa aaacatccat ctaagattat ggatgttttc 2291821 tctcttctct attcgaggtc gtaaccccgc tatcaaaaac aacgagaata tttgcatact 2291881 attggaggaa tacccatgta tcacaagaca cagcatcatc gatacattcc tggacttgat 2291941 ggccttcggg ctttcgccgt cctgtcagtt atcacttatc acctaaattt caattgggct 2292001 aacggtggtt ttatcggggt tgatatcttt tttgttttat ccggatattt gattacatct 2292061 attctattac cggcatatgg aaatgatatc aatcttgatt ttcgggattt ttgggtgcgc 2292121 cgcattcggc ggcttctccc ggcagcgtac cttatgatct tttccactgt tgtgtgggtc 2292181 gtattgtttg atcgagaact attgcacact gtacgtggag atgcgatctc ttctctcttt 2292241 tatatgagca attggtggtt tatttttcac aagctatcat attttgatag tttcggttcc 2292301 ccatcacctc taaaaaacct ttggtcgctg gcgattgaag aacaatttta tatcatatgg 2292361 ccgatgtttt tagttgttgg aatgtacata atgaaaagcc gcgccagatt ggctgcggtg 2292421 atatcattgc ttgtgctttg ttcagccgtg atgatgagcg tactgtatga acctggcgga 2292481 gatccgagcc gcgtttacta tggcacagac actcgttcgt ttgaacttct catcggatgt 2292541 gccttggctt tggtatggcc gatgaaaagg ctgtcttcca acaggctgcc aagcaaactg 2292601 aagcacactt tgcacgccac tgaatttttg gcattttgta ttttagtgtt gtgtgtctat 2292661 ttcacagatg aatacgagcc ttttctttac agaggcggaa tgctattcat tagcgtgact 2292721 gccgcaatcc ttattgcatg tgtttgccat ccgagcagct ttttaggcaa tctgctttca 2292781 tggaggccgc ttcggtggct tggaacgagg tcttacggaa tttatctttg gcactaccct 2292841 gttattgtgt taagcacgcc agttcaagaa atcggaaacc ctgttttttg gcatatcgtg 2292901 ctaaaggtca ttgtgacatg tatacttgcc gagctctcct accattttat tgagaagccg 2292961 atacggacac agggatttag gtcattttcc cgccgtgttt ttatacatag aatcaaggaa 2293021 tggaaaacga catctgtcat cagcaaaatg tcaattggtt tcattatttt cgctatactt 2293081 atttttgcag gcgggctgtc agggctagcc ggcgagcaaa agcaccctac caaatggacc 2293141 tatagctcac aagaaacaaa tgctgacacc agccaggctt ctggggataa aaagaacgct 2293201 gcagcagata aaaaacacaa tcctgaacaa aagacaacag attccaatca gggtcaaaag 2293261 gaaaacaaag atagtgggca agagactcat aaaaagaaag acacgcaatc ccaacagttg 2293321 aaaaaaccag cagacactgc gaaagaagtt ttagctatag gagattccgt catgcttgat 2293381 atttcttcac acctgcgtca gtcattttca aatgtgacga ttgatggaaa ggtagggaga 2293441 caaatgtctc aagctttgga actcgcaagg gaatacaagt cttttaatca gccgaacaag 2293501 gctgtcatca ttgagcttgg aaccaatggc tattttacaa acagccaaat cgaacaactg 2293561 cttcaatctt tctcaaaagc tcatatttat cttgtcaata cacgggttcc ccgccaatgg 2293621 gaaagcaagg taaatgaatc tttgcagcaa caggcccacg cacatcaaaa tgttacgtta 2293681 gttgactggc atacagaagc tcttcagcat ccggaatatt ttacccctga tggtgttcac 2293741 ttggttccta aaggggcaaa aactttgact gctcttattg ttcaggcgat gaaatcgtaa 2293801 aaaagagatc ctatacagat cactttttta ctttagtttc tgatcgttga ttatgtcttc 2293861 tttcagcaag gcagccctta tgtttacatg ccgtttacgt aagggtaagc caaaattgaa 2293921 tggagggatg ataatgaaag gaaatgaaga acatgacatc caaaaagagt tgaaacgata 2293981 tgagcttttt ttcaaaaaac gatataaggt tctttataca gtaaacgatt ttatcatcgg 2294041 tgctatgttt ctcgttggaa gttttttctt tttttatgac cggttaatgt cggcagggat 2294101 atggctgttt gcgatcggaa gtttgctgct gttaatcagg ccgaccattc ggctgattca 2294161 tgactttcat taccgtaagc atgtggaaca gcaattcaag catcaatctt caacagatga 2294221 ctgatcttaa ggaataagaa agaacaaaat gccaaaagcc tgagtcgaaa atcaaaaaca 2294281 agactttcag actatttatt tttaaaaaca aggtaaaaag aactaaactt ttgcctctgc 2294341 atgccgatat gaataataag gccggcgcga tactccctat aacatccttt tcagtagatt 2294401 tcattatcgt gccggttttc tcatatgcaa agcaatcccg ccaatcagat tggcgggatt 2294461 ttatatttta cattcctgtc caaacgtctt tcacataacg tctttgatct tgcagctttt 2294521 gcagccatac agctgattct tcctgacttg ctgctttttc agcttcatat gccaatcgca 2294581 aagttctctc tacatcagga gccatttgcg atccatcacc gcatacgtaa atatgagccc 2294641 ctttttcaat gagtgtcatc aatttctgcg tatcttgctt gagcaagtgc tggacatatc 2294701 cttttggttc gttttcgacg cgcgagtagc atcggcggat tgtgaccaaa ccgtcctgtt 2294761 ccgcttgatc cagctcttct ctgtaaaggt cgtcatggtc cgggcggcgg cagccgaagt 2294821 ataaaagtgc ttcaccaagg gtgcttcctt ccttcttcaa aaccgatctt gcctgaataa 2294881 agcctctgaa tggcgcaatt cctgtgcccg gcccgaccat aatcataggc gtttcaggat 2294941 cattcggcat ctgaaatccg gactgcggcg tacgaatgaa gcaagctgct gcatcacctg 2295001 tattcaattc tgctaaataa ttagaggcga caccccggta ttcacctcgg ccgctccatg 2295061 ctgaggcttt cacaactcct accgtcatgc tcacgatatt tgcatgaact ttcggtgagc 2295121 ttgaaatgga atagtatctc ggttttagtg atggcaaaag tgctaaaaac cgttcaaacg 2295181 gcatttcgca agcaggataa tcctctaaaa aatcaagcat ggtaagacgt tttgcaagta 2295241 cctgctcttt gtaaatgcca tcatctgaaa cgagctgttc cagctctttt tgatgcggcg 2295301 gacaaactgt ataagaggcc agctcccgaa gctgaagcct tgatgccggt tcctgcagct 2295361 ctacatagga cgacaataaa tccactactt tgattggccg atccatcggc agatgagcca 2295421 tatgagcgct tccgcttact tttatcacat gattggactg caaaccgaat cggctgagaa 2295481 cccgctgaac aagctccctg ctgttctttg gcaggattcc gatatgatcg ccttctttat 2295541 atgttttacc agccggaatt tccaattcaa tatggcgggt tgaacgcgtg ctggcagctg 2295601 tctggagttc tcgattctct aacacaatcc cttcaaacgc gccatatgct ttagcaaccg 2295661 gcgtttccgt cgcttcactg agaaaagtaa tcgataatga aggcctgtct tctttctggg 2295721 ctatttcgtt aatatcaaat gcgtccatcg tttccttcca gaagcggttt tcccaagact 2295781 cgcggtggct ttcaaaatca tcggcggcgt caccttcccc aatcgctgtt aaacgcgatg 2295841 ccccctttgc tttcatcatg tcatcaatca ggcggggaat ccgctgatac gtgctggccc 2295901 agctccggtt tccgcagccg aataccgcat aggaaacacc tttcaattgg ccttcctcaa 2295961 gctctttcag ccactctaca aatccggcag cattatcagg cggcgcccca ttataagaag 2296021 ccgttacaat gacgactgcc ccttcttcag ggagcttgcc gatataatca tcaagcggag 2296081 ccgtttcagc tgtaaagccc atctggcggc cttgagcagc cagttcaccg gctattccct 2296141 cagctgtccc aagatttgaa ccaaaaagaa caagtaaagg tgtgccgtgt ttaggtttgg 2296201 tttcttttgg ctttgtttct gctttgatgt ctgcctgttc ttttctctgt acattgattg 2296261 ccgctgtttt tcgcggtttc acagtaattt taaaatcatc cggcttgatc gttaatgctt 2296321 ctttgatttt tagttcgtag ccagtatggt ttatcaattc aaaatgcttt aatacaagac 2296381 cgagaaccat tgtcgcttct tgaagagcaa actgcatgcc aatacaagcg cgctgtccgt 2296441 ttccaaacgg cttatacgca tggtgaggga tacttgaagg atcctcaaac cgttccggac 2296501 ggaaatcttc cgcatccggt ccccaagcgt tttgatcccg gtgcagtttt ggaattaaaa 2296561 cagtgactgg ctgccctttg ctgatcggat attccccgcc tagaacagta tcctccttcg 2296621 catatagaga aaaagccgga gctgttggat acagtctgag ggtttcattt aaaaccatcc 2296681 gaatgtattt gagctgctgg atttgtttat attcaggcgt gtcatccgtt aacacgcgat 2296741 ccgcttcctc ctgagctttt ttcagttttt ccggatgtgt aagcagacaa taaatcgcaa 2296801 aggatagcaa cccgcttgtt gtctcatgtc cagcaattaa aaatgtgatg atttggtatc 2296861 gaatgttttc gtcatccagc gtttcacccg ttactggatc tttggcataa agcatgagag 2296921 acaagagatc cttaatgttt tcatccggat tcgcctttcg ctccgctatc attctatcaa 2296981 ccagggagtt catgacttct atatcctttt ggaactgcag cttcgttttc accatcattt 2297041 tatcttgcag gcccagtctt ttcgattgat tcatcgcctc ttttaaggca cggagcatac 2297101 tggtgataaa cggatgctgt gaatcacggt aaaagctgtt gaatcgatag ttaaacccgc 2297161 ataacccaat cgtatcaagc gtcagacgtg tcatatcgtc cgctacatca atttcttcat 2297221 tagggtttaa ccggctccac ttttgaatca gctgggttgc gatatccagc atcatagaat 2297281 gatagccttt catcgctttt tgactaaaac tcggcagcaa aatgcggtgg gctttttgcc 2297341 agttcggttc gtgcgtccag cttgtaaata agccatctcc cccgaactca cgcacctttt 2297401 gcaagccttt gccaaggttc ttgtcaaagc gtttttcatc acacacttca gccacaagat 2297461 tgtggccgga cacaaaaaca ctggatactc ccggaaaatc aaaacggaaa atcggtccca 2297521 attcatcagc tatccgccat aaggattgag aaagctgttc tttttccaga tgcggaagat 2297581 tttttaaagg tccgtatgtt ttgggctgag gtattgcgct tgcctgtttc attaacatct 2297641 ccctttccta tttttgtgat gaatgaagct taatggcgtc ccagcagcat tgttccaatt 2297701 cagtaattaa atcagtgtcc atctctatat cacctgtttg aacgagctga tatatcttga 2297761 gaaacgcccc taatacaatc gcaattaaca cattagaggg caggctgcga atcacgcctt 2297821 ccgcttttcc cttattaaaa tagtcatcaa gcatttgagt cagattttct atcatttttt 2297881 tgcttgtatg atttaagtaa tgagcgtctt ttttggtttc aagaaaaaaa agcgcatagt 2297941 cgctctcttt cgtaaactga acgagacagc aaaatacgtg gtgaaagcct tctctgacag 2298001 gcaattctga aacgtcttgc ttcagttttt ccgtaaatcg ctggatgctt tcttgaaaca 2298061 gtacgttaac gagtgtttct ttgctgtcaa aataacgata gatcgttcct gtccctacat 2298121 gagcacgttc agctatcata ggaatagtgg tagcgtcaaa acccctttcc gtaaaaagtg 2298181 agactgacgc tttcataatc atgtcgtatt tactgctgga tgcggatatc atgtaatctg 2298241 acaacctccg attcgtttac ggaatgaata ttcattcctt ttgttcacaa agaatgtctg 2298301 ccctgtctga tatcacctct ttgttctttc ttctgttata agtttatatg aaaaaaactt 2298361 tttttaatat aaagtatatg caaaaaataa aaaattaaga aaatataccc aaatcctaat 2298421 acgaggatct tggatatatt tcccgagaaa ttttttattt aacagccaca atacatagac 2298481 aggaagcacg cctgataaca gaaagatccc tgaaatgctg gtctttcagc agttgaatat 2298541 acgttttctc tttttcaccg gtatttgtgt caatactgat ataaaaccgg ccgtcaattt 2298601 gaagcaccct gtaaatttct cttaatgcaa gcctaatatc ggtgcagctt tgaaccgtat 2298661 gtaaagaaaa gactttatta aaggtacggt catcaaaggg aatgtcctct ggatagccat 2298721 gaaaaacctc cccgttcccc atgttctttc gattcgcacg tgatatctgt cttacctttc 2298781 gttttgaagg atcaatgctt tttaggctac ccttttttag tttcttggtt atgcttttaa 2298841 agacagtgcc gtttccaatt ccaatttcta aaattctgtc attttcttgt atatctatag 2298901 agtcaatcat catatgctca attgttttgg ttagcttata tttccgagaa aataatttcc 2298961 aaaaatccga tcgtttatag agtctatttt ctagcatttt aaacacctgc ttttggtttc 2299021 ctatgtttat ttattatctt aaaaaaataa acatcatctt catttctaaa agtgaaggaa 2299081 ggtaccaact agacggcaat gtattgaaaa atgtttcaat agaactaaac tttttcattt 2299141 ttttccgaaa aaaaagcaga aaacataatg ttttctgccc tctttctaat gccaatgata 2299201 agggaataca tacagccttt gctgctgcat tgccatcagc ctctgctgtc ggaatggatt 2299261 tccataacca tgtttgaagg aatgcggcat ggacgcataa ccatggccaa tcgacggcag 2299321 tcttttttga taatcgttca tcatgccatc acctgcctca caataacgtt gatttactat 2299381 atgcaggcgc gcattttctt gacagctatt tcgctaaact tggtccttct ccattgtata 2299441 atgcatcaat agttccattc taagcatatg ccattccccc ttcagttttt ttcgttgctt 2299501 ttagcgccag tttgttaaat aaagatgctt taactgagac tctttcattt catcataaat 2299561 ttgttcaatc tgctgttctc gttcgaattc ttccaggctt ttaaaccgtt ttttaatcgt 2299621 taacgttaaa aagaataggt taatcgtcat atcgctcacc ccctttcaaa gtccgcatca 2299681 agcgaaataa cccgcggcac aacccttctg ccgcgggcaa ataaaaaccg cagacaaaag 2299741 aagacaccaa tgcctctact gcctgcgggg agttgcgtat gtccgactat tccgaattta 2299801 atgcgtgcga taagcatcgg ttaaggaagg acacgaactc ttccacaggc tgaataaacc 2299861 atgaactttt acatgtgtat cacgtacagg ttgacgtcgt tgtctcattg tcattttggt 2299921 tcagcctcct ttgctttttt cttactttgt aagtatatcc accaaattcc attttgtaaa 2299981 catctttttc taaaaatgga cggaaattgt gcaaatcatc gaatggattt gcccgttggt 2300041 catgacacct gcttcatttc ttttctggag cggtctttct tatgatatgc aataaaataa 2300101 atgagaccga caaatacagc tccgccgatg acattaccga taaaagccgg aatgatgttt 2300161 ccgatgaact gcccccacgt gaatgagcct gcaaaaatgg cagcaggaat cacaaacatg 2300221 ttggcgacaa cgtgctgaaa tccgatagcc acaaaagcca tgattgggaa ccagatgcca 2300281 aggatttttc ctgctgcgtc ttgggcgccg aaagaaagcc acactgcaag acatacaagc 2300341 cagttacagc cgatggcgga aatgagaacc ttgccaaagc tcatatcaag ctttccttgg 2300401 gcaacggcaa tcgttttttc taaataagga cctgtttcag tcaatccaac caaatgcccg 2300461 aaaaagtaag caacaaacaa tgcgccgatt aagttcataa ttgtgacgat tccccagtta 2300521 atcgctaact cttttactga tatttttctc gaaaataacg ccatcgcaac tgacatcata 2300581 ttgcctgtga tcagttcagc gccagcgaga acgacaagga tcaggccgac tggaaatact 2300641 gctgcaccaa tcaaactgga caggctcccc cattctttcg gaagatcgcc aattaccctg 2300701 atatcaagca aatacccaag cgcgataaat gcaccgccta aaaaccccag cacaagcagt 2300761 gacggcagcg ggagctttat ttttttcatc cctgcttcaa ttgctgcttc cgctatttca 2300821 tccggttttc gaaaagccat aataaaacgc ctccattact tcttcttttc tcacagttat 2300881 gcaagaaagg caataaaaaa ggcagcactc aaataacctg tgtcaaacca ggcgtttgaa 2300941 tgctgcctaa cttgtatgca tacccataca acaatatcaa gcagtatata agatattgaa 2301001 agagaatata tacagttcgt gcatacattc cattgcttta gccttctata actgtagcaa 2301061 catcatatca aatgtgacaa atttgtgtca atgacaaata tactagcttt gcagagcttc 2301121 tttttgctca tctatttttc ggtcaaaaac aaatacagat acagcgatgt tttcctcaat 2301181 tttaatatca gaaaacaaat ggactagctt agctcccata agttcctcca ttccttccgg 2301241 tgtttgtttg gaataaaggt cttgaattag gcttgtccgg gccgcatgta ccatctctct 2301301 tccttcaggc gtgcgggcaa taaactgctc gcttgcactc agatttccgt atagtgttga 2301361 aactgccatg ttttctacaa atacagtatg aattctctca ggcccttttc cgaacaattc 2301421 tttgcgaagt tttcgaataa tatcattgaa ttcatgaatt tttttagaca tgctgattac 2301481 cccttccgat attgccttat aaaggctttt cccggttccc ctcaggacat ttcacttggt 2301541 taaaattttc ctgccatatt gtattataat aaatatcaca ttataataaa agcagtgttg 2301601 atggatttgt aataggatct tgttatgagt ctatcgtttt ataaaaatca aggattggtc 2301661 tgttagtaag acttgctagt gaactattcc gccatgtgtg tttacacctt cttagaatta 2301721 agggcaggtg tatctataca tggctttttt tgacttcttg aaagaaagat ggaggggaat 2301781 atgaatatga tggacgttaa gtcgatcagt gtccgtgtag acggaacaga aattcaagca 2301841 cgagcagggg ccacaatttt agatatttta aatgaaaacg gaattgagta cccgcagatt 2301901 tgccacgtac cagaggttga cccgattcaa acttgtgata cttgcatagt agaggcaaac 2301961 ggcaagctgg ttcgttcatg cgcgacggtt gcagaaaacg ggatgtctat tgatctttca 2302021 ggaaatcgag tgaaagaagc gcaaaccgaa gcgatggacc gccttcttga aaatcatttg 2302081 ctgtattgta cagtttgcga taacaacaat ggaaactgta cgctgcataa tacagcggaa 2302141 atgatgggga tcgagcatca aaaataccca tacacgccaa aagaagatcc ttcttgcgcg 2302201 gttgatatgt ctcatccttt ttaccgctat gatccaaacc aatgtattgc ctgcggccag 2302261 tgtgttgagg tctgtcaaaa ccttcaggta aatgaaacac tctcaatcga ctgggaacgc 2302321 gaacgccctc gcgtcatttg ggatgaggga gttccgatca atgaatcttc ctgtgtcagc 2302381 tgcggtcagt gtgtaacagt atgtccatgt aatgcactga tggaaaaatc aatgctcggg 2302441 caggctggtt ttatgacagg cattaaagag gacgtcatgg aaccgatgat tgatctcgtg 2302501 aaaaatgttg aaccggggta tggcagcatt tttgccattt ctgaagtcga agcggcaatg 2302561 cgtgaaacga gaacgaaaaa aacgaaaact gtatgtacgt tctgcggtgt cggatgttca 2302621 tttgaagtat ggacaaaagg acgggatatt ttaaagatcc agcctgtttc tgatgctccg 2302681 gttaacgcaa tttccacatg tgtcaaaggg aaattcggct gggattttgt caattcaaaa 2302741 gagcggatca caaagccttt aatccgtaaa aacggagcct ttgtggaatc ttcttgggaa 2302801 gaagccctcg atcttgtcgc aagcagatta ggatcaatta aagagcagta cggtaaaggc 2302861 tctgtagggt ttatttcttc ttctaaaatt acgaatgaag aaaactacgt cattcaaaaa 2302921 ctagcgcgtc aggtatttga aacaaacaac gtcgataact gctcacgcta ctgccagtct 2302981 cctgctacag acggattgtt ccgcactgtc ggcatgggcg gtgacgccgg cacgattaaa 2303041 gatattgcca aagcaggcct ggtcatcatt gtcggtgcca atccggcgga aggacaccca 2303101 gtgctcgcaa cacgcgtcaa acgggcacac aagctccacg gtcaaaaact gattgttgct 2303161 gacctgcgta aaaatgagat ggctgagcga tctgatctgt tcatcagccc taaacaaggc 2303221 acagaccaag tttggctgat ggctgttacg aaatatatga tcgaccaagg ctggcacgat 2303281 caggcgttta ttgatgagaa cgtcaattac tttgaagatt ataaagaaac ccttaaaacg 2303341 tatacgcttg attatgcaga acgcatcaca ggcctttcaa aagaaaacat cattcaaatt 2303401 gctgaaatga ttcgtgatgc tgacggcact tgtgtccttt ggggaatggg tgtcacacaa 2303461 aatacaggcg gttctgatac atcagcagcc atttcaaacc tgcttctcgc tacgggcaac 2303521 tatcgccgtc caggtgccgg cgcttatcct ctgcgcggac acaataacgt gcaaggcgca 2303581 tgtgatatgg gaacattgcc tggctggctg ccgggatatc agcatattac agatgacaaa 2303641 gcacgcgcta aatttgaaga ggcatatggt gtcgagattg atggaaagcc tggtttagat 2303701 aatattcaaa tgcttcatgc cattgaagaa ggaaaaatga aagctatgta tcttgtcggt 2303761 gaggatatgg cactggtcga ttcaaacgcg aaccatgtgc atgatatttt atcaagcctt 2303821 gatttcttcg tggtacagga catcttcctg tcaagaacag ctcaatatgc tgatgtcgtc 2303881 ttgccggcca ctccttcact tgaaaaagac ggaacattta ccaacacaga acgccgtgtc 2303941 cagcgattgt atcaggcgct tccgacgctt ggtgacgcaa aaccggactg gtggattatt 2304001 caagaggtgg caaaccgttt aggagcgaat tggaattaca gccatccaag tgacattttc 2304061 tctgaaatgg cgagtctttc tcctctgttt gccaaagcaa gctatgaggt gcttgaaggc 2304121 tggaacagct tcctatgggg cagcttcaca ggtgaaagca caccgcttct gtatgaagac 2304181 ggatttaatt tccctgacaa aaaagcccgc tttgcccttt ctgattggac cgagccagcg 2304241 gcatttccgg aggaatatga ccttcatatc aataacggcc ggatgctgga gcatttccac 2304301 gaaggaaaca tgacaaataa atcgaaaggc atccaagcga aagtgccgaa tgtattcgtt 2304361 gagatctcac ctgagcttgc acaagagcga ggtgtttgtg acggttcgct tgtacggctc 2304421 gtttctccgt tcggagcagt caaattgaac gcgctgatca cagaccgggt acggaaaaat 2304481 gaactctatt tgccaatgaa ctcgacagac aaggagtcag cgattaactt cttgacgggc 2304541 cctgcagctg ataaacggac gaacacgcct gcttataaac agacaaaggt ccgcatggaa 2304601 gtgcttggcg gctgtgaaac agcgccgctt ccaaaaacaa atccgcgcaa caaaaaacgg 2304661 catccgcaaa acggagtcga agcagaaaga aaatggaacc gccctggcta tgtacatctg 2304721 actgattaaa cgataggagg aaaacgaatg gccactccga ttacgacgat caaaaaagaa 2304781 acaaaaacag ctgagcaaat taagcttgaa aaaatagaag aactgaaaga gctgctggcg 2304841 gaaaatgagg acgccgtctc taaaacgatg acgttaatga atgaactcaa tgatcttgga 2304901 atttttgatg cggcaacaag catgctcaga gcgaaggaag acattgccaa gattgcgctt 2304961 ggccaagttt cccgcgagcc tgtcaccaac ctcatcaaca cgatgatggc cgccggaggc 2305021 gcattgacaa aagccgatcc tgagtttaca gcaaagcttt tagaaagcgt aatggctggg 2305081 actgaacagg cacaaagctt tttaaaagaa gacaagaaag tcgggattct cgacctgtta 2305141 aaagcaatga acgatcctga catcaacaga gccgtcgggt tcggccttca gtttttaaaa 2305201 ggcatgggaa aagaacttcg agaacaataa cagaaaaaca gccatctctg atgatggctg 2305261 tttttttatt cgtcggcttc ttccagacgc ttcttgtaaa taagtgaacg gtcagcgcaa 2305321 aagaaggcac cggctaaaaa tacgcaatcc gctaaaaaca tcgtcgattt ctggcctaat 2305381 gttaagcctt gatcagggag aactgcgcct atatataaaa aagtgctgac tgcaagcaat 2305441 gtaaaagcaa aatgcttgta gtcttctttt aaagatttca ttctattttt gttcaaaaga 2305501 atcacctgcc agattcatag tatacgacta ttataatata atccggcggc ttacagagaa 2305561 agtaattcta tccatttgtt atatattttc aagcgcttgg ccgatatctt ccaacaagtc 2305621 ttccgcatct tcaattccta cagaaattct gatcaagccg tccgtaatgc cgagctcaag 2305681 ccggcgttct ctcggaatag aggcatgtgt cattcttgca ggaacagaaa ttaagctttc 2305741 aaccgccccc aggctttcag caatggtaaa cagtttcaga tttcctaaaa acgcatcaac 2305801 ccgttcttca ctgccaatat caaaggagat catgccgccg aagcccgctc cttgcgtttt 2305861 tgcaagctca tgtccgggat gatttgaaga accagggtaa tataacgttt ggacagcagg 2305921 gtgattctca agaaagcttg cgattttccg cgcattttga tcgatcgctt ccattctgag 2305981 tcccaacgtt ttgattcctc tcattaacag ccaggaatct tgagggccga gcacgccgcc 2306041 tgtggagttt tgcacaaaat gcagctcttc tccaagctct ttcgaagctg tcacaactaa 2306101 acctccgacg acatcactgt gtccgccaag atattttgtc gcactgtgca gtacgatatc 2306161 agcgcctaaa gtaagcggct gttgaaaata aggagtatta aaggtattgt ctacgataag 2306221 cagaacaccc gctttttttg cgatatcagc catgagcgtc aggtcggtga ttttgagcaa 2306281 cgggtttgtc ggtgtttcaa tataaattgc ttttgtatta gggcgaatcg ctttttcaac 2306341 ttcttccctg ctgctcgtat caacaaatgt tgattcaatg ccaagacggt taagcacctt 2306401 tgtcatcacg cgatatgttc cgccgtacac atcatcagtc aacacgacat gatctccgct 2306461 gttaaacagc atcataaccg ctgtaatggc agccattcct gagctgaacg catagcctgc 2306521 ttccccgctt tccagttctg tcacaagtgc ttcgagagcg gttcgagtcg gattggccgt 2306581 tcttgaatac tcgtagcctg tatgctgccc tgctttcggc tgcttgtacg tgcttacttg 2306641 ataaatcggc acggaaactg cgcctgtttt ctcatcacct gtgattccgc catgtatcat 2306701 caatgttttt ttcttcatat cagatgcctc cttcgtatat ttgtttgctg atatatcgat 2306761 cgctgctgtc aggaaatact gtgacaatgt tagttccagc ggatgctttt ttcgcttcct 2306821 ccaatgccgc ataaagcgct gcacctgaag agcttccgat cagcaggcct tctttttctg 2306881 ccgcttcttt cacaagtcta aacgcattct catctgttac ggtgtagatc tcgtcaaaat 2306941 ggctcttatc catataatcg gggataaact ccatgccgat gccctctgtt ttatgagcgt 2307001 ggggctctcc tccgtttaaa atcgagccca ccggttcaac aatcaccgtt ttgactgctg 2307061 gatttttttc ttttaagaag gaagctgtcc ctgcgaatgt gcctcctgat cctgcccctg 2307121 cgacaaatgt atgaatattc ccgtcaagcg cttcccacat ttcaggtcca agcgtcttat 2307181 agtaagtcga tggatttact cggtttttaa attgcaaaac gcaataagaa ttttcaattt 2307241 cagtctccag ctgaatggct ttttgaatgg ctccctgcat tccgtcttga cgcggtgtat 2307301 gaatgattga tgcgccaagc gcttgcataa tttgctgttt ctctctgctg aaatgttcag 2307361 ggacacagaa aatcgctttc agcccatatt ttctggcact taacgcaagg ccgatccctg 2307421 tattgcctgc cgtagcttct ataatcactc cgccgggttt cactttgcct gaatcgagcg 2307481 cgtcacgaat cagcatatct cccagtctgt ctttgatgct tccccctgga ttcatcattt 2307541 caagcttggc atacaccgcg actccttctg gaacatcaaa gttcttcaag cggagaagcg 2307601 gtgtattccc aatcagctcg gtaatgtccg taatcactgt catatatgtc ctcctcctta 2307661 atagaggttg tttttagaga aaaacggagg agaacgttct ccccgtttta atgaattcgt 2307721 ttgatcacct ttaacacaag ctctgttgaa tgaacagccg cctgctctaa aaattggtca 2307781 aatgaaacat gtgattcttt gcctgcgata tctgataacg ctctgatgac gacaaacggc 2307841 gttttaaatt gatggcatac ttgagccact gccgcagcct ccatttcaac cgcgtacaga 2307901 tcagaaaatc tcgcacgcac ctcttcaacc cgcttcggat cgttcatgaa agaatcgcct 2307961 gttgcaatcg ttccttttgc aacctgaatg ccgtcgagtt cagataccgc ttcttcagtg 2308021 atgctgatca gcttttcatc cgccgcataa gcagccggaa gacccggcac ttggccgtat 2308081 tcatagtcaa aagccgttac gtctacatca tggtggcgaa cgtcagtgga aatgacgaca 2308141 tcccctacat tcaatgtatg atgaaatccg ccggctgagc ctgtgttaat gacataatca 2308201 ggcttgtaac ggtcaagcag aagcgtcgtg ctgatagcag catttacttt tccaattcct 2308261 gattttaaaa gaatcacttc agttccttca tattcgcctg ttgtaaattc acagtgtgcg 2308321 atcgtttctg tttttgcatt ttcaagtttg tttcttaaga tggtaacttc ctcttccatt 2308381 gctccgatga ctgctagtct catctattca cattcccttc actttaccgt ttgatcgcct 2308441 ccattatcca cacgaagtcg ttttgctgag tgaatcggac tgcaaaacct tcagctgtaa 2308501 acatttcttt caacgcatcc aatgtaggat aatgctctgt ctctaaatca tttgcaagct 2308561 gataaaagcc ttgagaacgg gctttatcga tagcctgttg atacgcttgc gcattttcaa 2308621 agacggtatc ggcaaacact attttatcat gcaagtgaag gtatttgcca tattgcttta 2308681 tggcagcccg cttttcttcg tcagtcaaat gatgaaaagc atatgaactg acaatcgtat 2308741 cagcctgaaa tggcggctca gggaatgtca ggaagtctcc atcaacgatt tccgtcctgc 2308801 ctgagagctt gtcagaagcc agtttacgca ttgctggaga aggttcgatt ccaaatacag 2308861 ttttgcctgc atcgagcagc ttagctgtca aattcccggt ccccgggcca aattctaaca 2308921 catgcgttcc agattttctg acgatggcat caaggatatg atcgtagcct ctgaacgctt 2308981 ctttatactg aatatctaaa ccttgtactg tttgatcata agttgctgcc caatcttcaa 2309041 agagagggat aaattcacgg cccatatttg tcacactcca tatttaataa ttcctataag 2309101 tatactatgg attaatgatg gaacagttcc tataatacca catattctga aaagcaggta 2309161 ctaaaacact ttgtgtattt tatgccatct catattgcgc attgaccgca aaaaagctta 2309221 tacttcatat gacttgtgaa agctggaggg tcaagacatg aattttcaat tagatctgat 2309281 taaagacaaa gtggaatttt ttgaagcggc ttcattgcag gagcttgaaa agaaaatcaa 2309341 tacacaaatt gaaaacaata aagccatcat gctccgggtg aaatctgttt cacaccaaac 2309401 tcttgtggca gaaggaagaa tattgtacag cgcggtggtt catttctcag ctgaagccta 2309461 aaacaaaagc agccggtttt aacccggctg cttttgttta ttttagcttt tctacttttg 2309521 tcggcttcca gcctttttca tcgacccatg taatcgtgac ttgatattta ttcccagtcg 2309581 ccttgtccaa aatcttgcct ttggcatcct gagggctgcc gttatttcca agccagagca 2309641 ccgtcatgtt atctgttgag acaccagttg cgtacgaaat ggctttcagc atctcagccc 2309701 agtcttgtga gcttgaatca taagtagcgg catgctcgcc agtctgctca gttccgactg 2309761 ctttccagtc aggattttca tacgtttttt ccacatcgct cgatgagccg ccttctgtta 2309821 cttttgcatc tttaagcccg tcaccggctg aatctgagct tgaatctgaa tcagagtcat 2309881 cttttttaga agaagaatca tcttttttgg aatcagagtc agaagacttc tcagaatcct 2309941 tttcgctgtc agatgtatct ttcttgctgt cttttatatc ctcatccgat ttcttttccg 2310001 tctttcctga agccggagat tcctgttttt gcgccgtttc agaatccttg ctgacatctt 2310061 tgctagaagg actgttaatg aagagattcg ctgctactac gacaattagt atggatacga 2310121 ttgcgattaa aatgttaagc actaaattgg cttttctgcg tttatcacga ttttcataac 2310181 gagattgatt attgctcaat aattctgcac tcctttatcc ctcttggctc agcatatatt 2310241 ttaacatgtg ctgagaagtt gttctatttc tgattgattt caatttcgtg tactttttta 2310301 acaatatcat aaaacaccga atttgtcaga gccttatctc ccggtgtatc catgtgtaaa 2310361 acaactagag cgtatttcgg cttatccgcg ggaaaatatc cggcaaacca tttttcgtag 2310421 agcgtttcct tctcttttga aagcttgcct gtctgggctg tgcccgactt ccctgctaca 2310481 gtatacggaa gatcttgaaa ccttctgccc gttccggaag gagattctac tacccgccgc 2310541 agtatttttt gaagctgctg tgacgtatat ttgtctatcg tttccccttt gagcttctga 2310601 tctttaaacg taacgagcgt tgtgccgttc ttatactcaa tttgttcggc aattttcacc 2310661 tgccgttttt ctccgccgcg ggcgattgtc gccatcatat tggctacctc cagcggcgtt 2310721 acctttacat ttttctgccc gattgctgtt tgcgcaatgg cttttttgac tgatttgtct 2310781 ttttcatccc cccaaatcac gccgcttttt tcgttataca gctggcggaa atcggtttcg 2310841 tggtacagtt ttccctccca gcctgcccga tcagtgagag ccagcttctc ggacatatct 2310901 tcaataaccg agctgtcttt tttcattaat tgttctgcaa gactcgtaaa tgtgtaatta 2310961 cagctttggg caaaactttc atcaaaagac aaggtgcctt tgtcgtcccc cggttccccg 2311021 tacaggttta aattgcaatt aaaggtttga ctaggcttca ccatattatt ttcgattgca 2311081 gctgcggcaa tgactgtttt aaaaactgat ccgggataga ttggcgtcag catataattt 2311141 tgaagtgtgt tttgccggga cacgtctgca tctggtttgc ttacaattcc cagaacactg 2311201 ctattttcga tgtccagcag cacagctcct ccctttttca gcccctgttc atccaatacc 2311261 tcctccatcg ctttttgaat gctttgatcg atcgttgttt tgatctggag cggataaaat 2311321 gtattggctt cagctgtata tttgacgtcc atgccaaaca aagggtttcc ttttccgtcc 2311381 acatgatata aaagctttgt gtcttgttcc ggaagcaaaa actcgtcaaa tgtccgttct 2311441 aaaccggttg ttccgatttc tgttgtaatc ggaaggctct ccttgtcagg atatttcttg 2311501 cgaagcagcg ccggatcttg gttcgtgctc cctatcgtat gtgaagcaag gctgggcttg 2311561 tcttcattct ccatatatac gccgtaaatg ccgggatatt tcaaagaatt gatttttgtg 2311621 atagattgtt ttgaaagtgt tttgattttc ttttgctgca aaatgaccgg tttttttgcc 2311681 tgacctagtg tctggcgcaa atcatcttca gacatgccga ggatgtccgc aacttttttg 2311741 atcggccaat cctgcgtcag cagaaaaggg aacaaaacaa ccgcaggctc gctttgtcct 2311801 gtcagcgccc gcccgtttcg atctaaaaaa gagcctcttc catctgaaat gagcacttcc 2311861 tccgtccgct gtttcacact ttcttgaatc aaattaattt tctttttaga aaatgattct 2311921 gtgaaaaaca gctggatttc tgcaagtctc agcagaagca gaaaaaatac aatcaaaaaa 2311981 gcgatgactg ccagcttcat tcgtttcgat atcttcataa aaaaacacct cacccacatt 2312041 gtggacgagg tgtttcgctg ctaaacagat attatgaaat tttcacaatt ttcacgagca 2312101 tttctccgcc cggtgtttgt actgtgactt cttcatctac ttttttgccc aagaggcttt 2312161 ttgcgatcgg tgaatcgttt gagattttcc cttcaaacgg gtcagcttcc gcgcttccga 2312221 cgatcgtata tgattcttca tcaccgtcag gcagttcgac gaaagtgacg gttttaccca 2312281 aaccgacaac gttagagccg ccgtcatctt caatgatttt cgcattgcga atcatatttt 2312341 caagagtcgt cacgcggccc tctacaaatg cctgctcttc tttcgctgaa tcgtattcag 2312401 agttctcgga aaggtctccg aagcttctcg caattttgat tcgctctact acttcttttc 2312461 gtttaaccgt tttcaaatat tctaattctt gttcaagttt ttgttttcct tctgcagtca 2312521 taggaaaaac tttctcttgt gccatgtccc ttcactcctt ctggttgtcc ctcaacatct 2312581 tcgattatgt atgagagcat aaactaaaaa atacaagaat gagaacacag ggcagtcctc 2312641 gttcttctct cccatatagg tactgtttat cttaaactga atcgtgtcgt tctgcaaata 2312701 tttcgcgttt ataaacaggg aaagaaggga attcgcacat tcccttcctg cctatacata 2312761 atatggtcag agttatttat gtctatgcta tggtattaca aaatcgcgtt ttgttcaaga 2312821 atggtttgaa tttttgtgac catcagatca attgcgacgt gattctgacc gccttccggg 2312881 ataataatat cagcgtatcg tttcgtcggc tcgacgaatt ggttatgcat cggacggacc 2312941 actgacacat attgttcaat gacagaatca atagagcgtc cgcgctcatt aatatctctc 2313001 ataatccgtc tgatgatacg caagtcagcg tccgtatcaa cataaagctt gatatccatc 2313061 agatcacgaa gccttttgtc ttcaagaaca agaatgcctt caaggataat aacatccttt 2313121 ggctctacgt gaaccgtttc ttctgaacgt gtgtgaagct tatagtcata aatcggcttt 2313181 tcaatcgggc ggtaattcaa tagatcttga atatgctcga ttaaatagtc attatcaaac 2313241 gcaagcggat gatcatagtt tgtgttcagc ctttcttcaa acggaagatg gctttggtct 2313301 ttataataaa ggtcctgctg gatcattaaa attgagtgtc ctttaaactg ttcataaatg 2313361 gaccgtgtga cactcgtttt tcctgaaccg gaacctcctg cgattccaat gactactgga 2313421 ttcttaccca tgggctgtta cttccccttt ctcatcatgt tgctcggata aatctttttg 2313481 tctagtttga atttgacaat ttgcagggga tggcgggcag catctagctc atttccgtct 2313541 tcgtcccaaa tggtttcaat cgtatgtgta aagttttcga tttctggacc gaaaaattcc 2313601 acttcgtcgc cttttttgaa gaaattgcgc tgctgaagcg tgaccatttg tgtatcttca 2313661 tcataattca gcactaagcc gacaaaatca tatgtcgttt tcttggcgtg ttcgccgaac 2313721 atttgctctt catagcctgg cgttccttca aagaaagctg tcgcagtgtc cctgttggcg 2313781 cacttatcaa gctcttcaag ccattctttt tgaatcacaa agttttctgg atcagcgcaa 2313841 taagcatcga ttactttgcg gtatacgctg acaacagttg ctacatagtg aatggatttc 2313901 atgcggcctt caatctttaa gctgtcgatc cccatttcaa tcatttttgg aatggattca 2313961 atcagcttca aatctttcgg gctcatcgca aatggtgcat cttcttcacc atacaaagca 2314021 acggcgttgg caccgtctgt ttggtagaga tcataatccc agcggcatga ctggcagcag 2314081 cctccgcggt tggaatcccg cgctgtcatg tgattgctca gcacgcagcg gccggaatat 2314141 gcaatacaca ttgcgccatg aatgaaggat tcgatttcga tatctacctt ttctttcatt 2314201 tctctgattt caagagcgct agtttcacgt gccagcacga cgcggtcgag accttcttcc 2314261 ttccagaact ggacagcctt ccagtttgaa agagactgct gtgtgctcaa gtgaacctca 2314321 acattcggcg ccactctgcg gcatgtttca ataataagcg gatctgccac aataataccg 2314381 gcaacgttgg cgtctccaag cgcttttaaa tagtcttcaa gcccgtccat gttttcatta 2314441 tgagcgaaaa tattcgttgt tacgtagatc ttcgcgccat atttctttgc gaattcaacg 2314501 ccttctgcaa tttcttcgat cgtaaagtta tcggcattcg agcgaagccc gtattcctgt 2314561 cccccgataa agaccgcgtc cgctccgtaa tgaacagcga ttttcagctt ttcaagatta 2314621 cccgcaggtg cgagaagctc cggctttttc gtaatcacac gctttccatt aacgattgtg 2314681 gatattttat catttacggc agtcatagct taacctcctt ttgattaata aaccgtttcc 2314741 ttgaagaaga atccggtatc aatttttctg tttactggct ggatgctttc aatgcgttcg 2314801 atccagtctt cttttttcgc ttcgtattcg tcacggtttt ccacgcacaa atcaattgct 2314861 tctctgtaca ttttggtgac ttctattagg tattcaggca ttttcaaaac accatcgatt 2314921 ttgaaagaat caattccggc atctatcaat tcctcgagct catcaatgat gcacacatcg 2314981 ttcgggctca tgatgtgagt gccgttttca tcttcgaaaa tcggatattt attatcgcgt 2315041 tctttatcgt gtaaaaacat gcctgattct tttttctttc tttcaatgtc catgactttg 2315101 ccctgatatt caaaatagtt tccaatcaaa gaacgcttcg attggaacat gcacgtcatt 2315161 ccatgcacct ggatttcaat ttcgacttca gcattttctt taatctcaac aatgctgtcc 2315221 atgtttaatt ctctggcaag cacagaacgc gccgcaccct tgcgtcccca gtagttgcat 2315281 gtataatagt tggtgcctgt cgtttctgtg ctccaatgaa gcttcagatc aggcgcagat 2315341 tcacgggcag ccatcagcac ggcaggatcg ccgaataccg ctgcatcgac accggcttct 2315401 gctaagaaag ccagatattc gccaagctca cccactttat cattatggaa aattgcattt 2315461 acagcaacgt atacttttgc cccttctttg tgagcaatct ctacggcttt tgttacatct 2315521 tcacgagaaa attctccggc taatctcaag ccgtatctct gttccccaac taaaaacgca 2315581 gttgccccag cctgtatgag cggcaaaatg tccgctgtac tcgtcggcgt cactaagagc 2315641 tctggttttt tcatgacgtt cacctcttct ttttactaat cgcaagtccg tccccgacag 2315701 gaataatcgc agtttgataa tccggatgat tcatcagcca atgattatat tcatcaattt 2315761 tggctacaag cctgcgcctt ctcttcggtt ctattttgct gtaatcctct gccaccagac 2315821 ctttaaacag cacgttgtct gttataatca ccccgtccgg tgaaagcatc ggttcatata 2315881 aatgaaaaaa gttttgatac tgaccttttg cagcgtcaat aaaaatgaca tcgtaaggcg 2315941 cggttacatg aacggcgtcg gctaattcaa gcgcatctcc gtaaaaaaca tgaatccggt 2316001 catcaagctg aaattccttg atattgttta ccgcttcttc atgccgtttc tcattgcgtt 2316061 caattgtata tatttcagca gacggcagtt ccagagccat tcgaatggct gaataaccaa 2316121 tggccgttcc gatttctagt atttttttcg gctgtttcac agacaaaatt tgaagcagca 2316181 cctccatgcc cgctttttcc ataatcggga catgatgttc ttctgcatat gcttcaagtc 2316241 tcttcacgtt atccggccga ggctttaata atgcttctat atagtcattt atttgttcat 2316301 accggtcagt cactacaaac agcctcccgt tctaaaaagg agtgccccag tcttatgcgc 2316361 aggacactct ctgaatacat catgatacat cggtaaacaa cccgatatat tttatcataa 2316421 aaccttgcgg aaagcgaaca aaaggagagc tttttgctct ccttttattt ctcatttttt 2316481 gaggaaatgt atttttcttt tgctttatta tgctctttta gcgtttttgt aaatacgacc 2316541 tcaccatttg atttggccaa gaaatacaga tagtccgttt tatccggatg cagcgctgct 2316601 tcccatgatg acatgccggc attggcaatc ggccctggcg tcagccctgt gtttttatac 2316661 gtattgtatg gtgaatcgat ttccagatcc ttataaagaa cccgatcttt atgcttgcct 2316721 gccgcgtaca ggacggtcgg atctgtttgg agcggcattt tctttttcag gcggttataa 2316781 aagacgctcg caattttatg gcggtcggct ttttcagtcg cttcttcttc tatcaaagaa 2316841 gccattgtca gcagcttatg cacagaaact ttgtttttct tcatttctga tttatatgtt 2316901 tccacataag aatttgtctg cttaatcatt gccttgataa tgtcttcaag tgatgtgtcc 2316961 ggatcgttaa aagggtatgt agccgggaat aggtaccctt caagcgggtg cttaatgttt 2317021 ttattgaaaa catcatttgt cacagtgtcc gggaattctt tcttcagctg attgataaat 2317081 gtttcatcgt ccagcttcgc tatgacttgt tttttagagt attttgtttc atcagcaata 2317141 gcagccgcga tttgggtcag ctgtgctccc tcagtcactg tgatttgaaa agcgtaacct 2317201 gtagccccgc ttgtcagctt ctgaataatg gcatctaaat ccataccttt attcagatgg 2317261 tagaatccgg cctgaaaccc ggaagcacct ttatatttca catagtactg aaacgccttc 2317321 tcgcttttta tgacatcatt tttctttaat atcgatgcga tggctgaaac agacgaaccg 2317381 ctcggaatgt taatattaac tgtcgtttta ctgtcttttt caacaggttc aagcaatgat 2317441 ttcccatata aaaatgcccc gccaatgatg agaaacagca caacaatgga agacagtatg 2317501 attctttttt tattaaaaaa cgattttttt tgctgattga tatacattag gtctcctccc 2317561 atcagctctt atactacatg attcattgta tttcggcaat ttattacaaa aagaggcctg 2317621 cataaagcag aaaaaagccg gagcagtata gctccggctt tggtttggcg cgatgtttta 2317681 ctcttcgtct tcgtccgcta agaatgtgtt tagtgtttct tcgatcatat cccattcttc 2317741 gtcagtttca atcgggaata gctcaccgtt ttcaccgtct tcgtttggcg tgaagctgga 2317801 agcaagaatt tctacttctt cgtcatcttt tgattcgatt ggatagtaca agacataaga 2317861 tttgccaaac tcttcatttt caaatgtaaa cagcacttca caaagctgtt catttccttg 2317921 atcgtcaaca attgtaatat ttttttcgcc gtgttccatt ttcttcacct ctggctttaa 2317981 tttaagctgt caagatatcc ttgtaaaatc ataacagccg ccattttatc aatgactttt 2318041 tttcgttttt gcctgctgac gtcagctgca atcagcattt tttcagccgc cattgtggta 2318101 agacgctcgt cccacagcac aacaggaaca ttgtacgttg tttcaagcac tttcgcaaat 2318161 gtttggctgg cttcgcctct cgggccgact gttccgttca tgttcttagg aaagccgagc 2318221 acgattttat ctatagtata gtcctttatc agttcagata aacgggataa accataatcg 2318281 ccttctgctt catttatctt tatggtctca atgccttgag cagtccagcc catttcatcg 2318341 ctcagagcta caccgagtgt tttggttcct aaatcgagtc ctaatattct cattctttat 2318401 ttacgcctct ttatgctgtt ctaaataaga ctttaccaat tcctcgatta attcgtctct 2318461 ttcaagtttg cgaattaaat tgcgagcgtc acgatgccta ggaatataag cgggatcacc 2318521 tgacagcaag tatccgacaa tctggttgat tggattgtag cccttttcct gaagcgcgtc 2318581 atacactgta atcagcacct catttacgtt agtctcagca gaatcatcgg agaaattaaa 2318641 tttcatcgtt ttatcaaacg agctcaccgt tttgcacctc tttcccaaat tcgcaggcaa 2318701 agttcagcct ggggtcctaa tcttaccatc attctacact acatgggcga attataaaac 2318761 ggatttcacc caatcttcta cagaagccaa agcttcttct aatttttccg gctgtttacc 2318821 gcctgcctgc gccatgtccg gacggcctcc gccgcctccg ccgcaaactt ccgcagcttg 2318881 tttaaccagc ttgccggcgt gaagtccttt ctcaatgagg tcctttgtga ctccggcaga 2318941 gatattaact ttatcgtttt gtaccgcacc aagcacgatc accgcagagc caagctttgc 2319001 tttgagttca tcgaccatag tgcggagatg attcatgtct tttgcattta cttttgccgc 2319061 aagcacgttt acgccgtcaa cttcttttac tttcgacagg attgctcctg cttccacgtt 2319121 gcctagtttt gcaagaagag attcattttc tctttgtgca tccttcagtt cagcctgcag 2319181 agccgcgacc cgtttcggca cttctttgat atttgttttc agctcgtcag cggtctgctt 2319241 caatacagaa atctggctgt tcatttcgac gtaagcgcct tgtcccgtta cagcttcaat 2319301 ccgtcttgtg cctgctccga ttccggattc agaaacgatt ttaaacaagc cgatttctgc 2319361 tgtatttctg acgtggcagc cgccgcacag ctctaagctg taatctccaa cttgaacgac 2319421 acggacaata tcgccatatt tttcgccgaa cagtgccatc gcacccattt cttttgcttc 2319481 agcgatcggt ttcaaatcaa tgctgaccgg gatgctcgcc cagatctttt cgtttacgat 2319541 tctttcaatt tgttcgagct cttcttttgt cacttggcca aagtgcgaga agtcaaaacg 2319601 aaggcggttt tccgttacaa gagagcccgc ctgattgaca tgagttccaa gaacatcttt 2319661 tagagcctga tgcaataaat gcgttgccgt gtggttttta atgacgccgc ttctcatatg 2319721 gtcttcaact tcagccgtaa catgcaggcc tttttgaaca gtaccgctct ccacaacacc 2319781 ttcatgcaca tgctggccgt tcggcgcttt ttgaacatct ttaattctta caactgcctg 2319841 ctcgcttcgg agatagcctt tgtcgccgat ttggccgccg ctttctgcat agaacggtgt 2319901 ttcatcaaga atgatttgaa cgctttctcc ttcatgagcc tcttcgatta attggccgtc 2319961 ctgaagaagc acaatgatat tggcatcagc tttggtttga gagtagccga caaatgtgct 2320021 ttcaactgtc acgtcgcgca gtgcgccgcc ctgcacctgc atgctgccga catcctggcg 2320081 ggcgtttctt gcccgttcac gctgctggtt catttcctcc tcaaagccct catggtcaac 2320141 cgtcatgttc tcgtcttctg cgtattcttc agtcaattca accgggaatc catacgtatc 2320201 atacagttta aacacatcag cacctgagat aacgctgctg cccttgtctt tttctttttt 2320261 gatcatttct gacaggatcg caagcccttc attaagggtc tcatggaagc gttcttcctc 2320321 ggttttaatg acttttgcga tgaaatccgc tttctctttc acttcaggat agaaatcagc 2320381 catgatttct gcgacaaccg gcactaaatc aaacatgaac ggacgatgga tgttgatcgt 2320441 tttggcataa cgcacggcac ggcgtaataa gcgtcttaat acatagccgc ggccttcatt 2320501 tgacggcagc gcaccgtcac tgacagcaaa ggcaaccgtt ctgatatggt cagcaatcac 2320561 tttaaacgca gtgtctttca cattgtcttt gccatatgtt tcaccagaaa tcgattctgt 2320621 tgctttaatg atcggaacaa acaaatcggt gtcaaagttt gtcggaacat tctggatgac 2320681 agacaccatt ctttcaagac ccatgcctgt atcaatattt ttctttggaa gcggtgtgta 2320741 cgtgccgtca gggttatggt tgaactctga gaacacaagg ttccatactt ccaggtaacg 2320801 gtcgttttcc ccgcctgggt aaagctccgg atcttctgga tcattaccgt atgcttcacc 2320861 gcggtcgtaa aagatttccg tattcggtcc gctcggccct tcaccgatat cccagaagtt 2320921 cccttccaga cggataattc tttcttcagg aataccgatt tttttcgccc aaaactcata 2320981 tgcctcttca tcttcaggat gaaccgtaac agagagaagc tctttgtcga agccaatcca 2321041 cttgtcgctc gttaaaaact cccaagccca tgtaatggct tcttctttga aataatcgcc 2321101 gatggaaaag tttccgagca tttcaaagaa agtgtgatgg cgcgcagttt tacctacatt 2321161 ttctatatcg tttgttctga tcgctttttg agcgtttacg attcttggat tttccggcac 2321221 gacacggccg tcaaaatatt ttttcagcgt cgcaacaccg ctgttgatcc aaagcagtga 2321281 aggatcctca tgaggcacta atgacgcgct tggctctacc gcatgtcctt tttctttaaa 2321341 gaaatccaaa aacatttgac gcacttccgc agaagttaag tgtttcattg tatttcctcc 2321401 tctataaaaa tcgaaattct cttcagtgac agcaaaaaag ccctccccct atgcaaacca 2321461 acgtttacac agggacgaga gctgtctcgc ggtaccaccc tgattacggg cattcatgcg 2321521 cccgtcacct ttaaccctgt aacgcaggat aagcggcagt gattaactgc actcaggatt 2321581 agcttcctcc gatcttctga taaagctcct ttcagcttat ggagcttctc tctttaacag 2321641 ggcttcggcg tactcagatc cgtcactcga gattcgtatg tattctacga gaaattatag 2321701 acaagcggca cgccgatgtc aatgctccgt cctcatccgc aaaaaatgga tcatcattac 2321761 ttttaaaaca gccgtcgcag gaacagccag aatcatcccg acgatacccg caagctcccc 2321821 tccggcaagg agtgcaagca tgataacgac cggatgcatt ttaaggcttc tgccgacaat 2321881 gaacggactg aggatatttc cttccataaa ctgcagaata aacaccgtaa tcaccacaac 2321941 aagaaccgcc ttgactgaga tcgtcatcgc aattaacaac gcaggaacag ctccgatgaa 2322001 agggccaaaa tacgggatga cattcgttac cccagagata aggccaagta tcagcggata 2322061 cggaagccca aatacccaga acgaaatgcc tgcaatcacg ccaagaatca agcagaccaa 2322121 aagctggccg cggatataat cgccaagcga atcatccaca tcccgcaaaa aggcgctgcc 2322181 ccgctttctc cacgacttcg gagtcaagta ccatactgtc tttttcatta actcaatgtc 2322241 cttcaccata taaaacacga gaaaagggat tgttgcagca attaagaagt aatcaagcac 2322301 attgcggatc ccgctgatcg caccctcgat cgttcccgca aaaaacgcct ccgtctggcg 2322361 gatcatttta tctatacggt gatgcatacc atcaggccag tcatccgtat ggttatgcac 2322421 atgaagaaga agcccgttat acgtttcggc aaacatgggt atattttctg acaaatccgt 2322481 cagctgcacg attaaaacag gcaccccttt atacaacgcc cagccaatcc cgccaaaaaa 2322541 aagaacataa atgaccaaga tgctcaaagt cctaggcaat cctttgccat gcagccattc 2322601 tgtgaccgga agcaataaat aagatataaa aatagaaatg atcaagggaa taaagatcgt 2322661 ttttatgacg agccaaaagg gtgaccataa catatcaagc ataaaaaaga catagactgt 2322721 taacagaacc agcaaacaaa tagccaccca caacaaaagc tgcaccggtt tttggagcat 2322781 ctgctttcac ctcacctata tcttttgagg tttacaagga attattcttt atgtttcttt 2322841 agtcagtcag aagtcatgga cattttttca cttttaattt tcagaaaagt ttgatcattt 2322901 actttttggt caaattttct gataggagga ttgcgatgat cacatttcaa aatgtaaaca 2322961 agcattacgg agattttcac gtgttaaaac aaattaatct tcaaatcgaa aaaggtgaag 2323021 tcgttgttat catcggccca tccggttccg gtaaaagcac attgctcaga tgcatcaaca 2323081 gacttgagtc gatcaatgag ggagtgctta cagtaaacgg caccgccatt aacgacagaa 2323141 aaactgatat caatcaagtg cggcaaaata tcgggatggt gtttcagcac tttcatttat 2323201 atccgcataa aacagtgctg cagaacatca tgctggctcc ggtaaaagtg cttagacaat 2323261 cacctgaaca agcaaaggaa acggcgcggt actatcttga aaaagtcggc atcccagaca 2323321 aggctgacgc ctatccttcc cagctttccg gcgggcagca gcagcgtgtt gccatcgcaa 2323381 gaggactggc gatgaagccg gaggtcatgc tgtttgacga gccgacatca gcacttgatc 2323441 ctgaaatgat cggtgaggtg ctagatgtca tgaaaacact cgccaaagaa ggcatgacaa 2323501 tggttgtcgt gacacacgaa atggggtttg ccaaagaagt tgccgaccgg attgtcttca 2323561 ttgacgaagg aaaaatttta gaagaagcag tgccggctga attttacgcg aacccgaagg 2323621 aagaacgggc ccgcttattc ttaagccgta ttttaaatca ttaaaacaga aatgggggag 2323681 cttgtatgaa aaagattttt tctttagcat tgatttcttt attcgctgtc atcttgcttg 2323741 ccgcttgcgg cagcaaggga tcaaacggag aagcctcaaa ggagagcaaa aaagatacgc 2323801 tagccgccat taaagacaat gacaaaattg tcttcggcgt aaaaacggac actcgactgt 2323861 tcggtcttaa aaatccaagc tcaggtgaga ttgagggttt tgatattgat attgctaaac 2323921 aaatcgctaa agacatttta ggtgatgaga aaaaagctca atttaaagag gtcacctcaa 2323981 aaacaaggat tcctatgctg caaaacgggg atatcgacgc cattgtcgcc acaatgacga 2324041 tcactgaaga acgaaaaaag gaagttgact tttctgatgt ctatttcgag gccgggcaat 2324101 cgcttctcgt gaaaaaaggc agcaaaatca agagtgtcga gaatcttggc aaaggctcaa 2324161 aagttcttgc agtaaaaggc tccacctcct ctcaaaacat tcgtgaaaag gcgcctgaag 2324221 catctgtttt agaatttgaa aactacgcag aagcctttac agcccttaaa tcggggcaag 2324281 gcgatgccct caccacagat aatgcaattt tatatggaat ggctgatgaa aataaaaatt 2324341 atcaattaac aggaaagcct tttacagatg agccttacgg gatcgccgtg aaaaaagggc 2324401 aatctgctct cgcgaaagaa atcaacgctt cacttaaaaa gatgaagtcg gatggcagat 2324461 acgatgaaat ttataaaaaa tggatcaaag aagacccagc tgaataacaa ccatcccggg 2324521 atgagcaggc gatgctcatc ccaatttgat aaggagtgaa taggcagatg aatgtgtcaa 2324581 ttcttttcga taacttcagc atgtatatgg acggttttta ccataccttg ctcgcaagtg 2324641 ttatcgcgct ggccggcagt tttgtcctcg gcgttgctgt agcggttatg agaataacag 2324701 tctttaagcc gctgcaatgg ctcgggaccg catatgtaga attcatccgc aacatccctc 2324761 ttcttttaat tacctttgtt ttctatttcg gacttccaaa cgcaggcctg aggcttgacg 2324821 gttttcaagc gggaacggtt gctctcacca tttatacctc tgcgtttatc gctgaagcca 2324881 tcagagcagg catccagtct gtttcaaaag ggcagatgga agcggcacgc tcgtcaggct 2324941 ttacctacag ccaagccatg ctccatatca ttttgccgca ggcaatcaaa atcgtcattc 2325001 cgcctttagg caatcaattt ttaaacttag tcaaaaactc ttcgattctt ggggttgtgg 2325061 ccggattgga tcttatgtac caagccgatt tagtttcgtc gagcacactc gttgtatttg 2325121 atgtttatat ttttgtggcg cttttttact tagtgctgac gattccgctt agcatcggtg 2325181 ttaactatct ggaaaaacgg ctggaaaaaa gctattgata aggagtgagt tacattggat 2325241 ttcatcggtg cttattcaca ggagcattta gcgtttttat gggatggctt tctcgtcacc 2325301 ttgtacgttg ctttcatctc catcattctg agctttttct tcggtttaat cgcaggcacc 2325361 ctgcgttatg cgaaagttcc cgttctttct caattgattg cagttctcgt tgaaacgatc 2325421 agaaacctcc ccttgctgtt aattattttc tttacgtttt ttgcccttcc ggaaattggg 2325481 attaagcttg aaattacagc tgctgcaatt acagcactaa cgatttttga atccgctatg 2325541 ctatctgaaa ttatccgaag cggactgaaa tcaattgaca aaggacaaat tgaagcggcg 2325601 cgctcctccg ggctgagcta tacacagacc ctgttcttta tcgttatgcc gcaagcgctt 2325661 cgccgcatgg ttccgcccat cgtaagccag tttatttctt tattaaaaga tacatcgctc 2325721 gctgttgtga tcgccctgcc tgaactgatt cacaacgcgc aaattattaa cggccaaagc 2325781 gctgacggca gttatttttt cccgatcttt ttacttgcgg cccttatgta tttcgcagtc 2325841 aactacagcc tttcactcgc agcaagacgc ctcgaggtcc ggcaaacata gaaaaggata 2325901 ctctttggag agtatccttt ttgcattaaa acattttcgt aattcttctt ctcatccgct 2325961 tcatgcttcg attattcagc atgtcagatt gagtcgccat tcggtacacg agagctccgg 2326021 ctcccattgc caaaagagaa gtcatcgtcc gattcatcct gcgcatctcc tttcatgatt 2326081 aaaaattgat gctgcgttca tcctcagaaa acaaatcatc caagctgctt aacgttccgt 2326141 cttcttccac ctgatgagtt gcaatcttcc ctttcgccac tgtcagttca ataaaacagc 2326201 cccagcaata atattggttc acgccgattt tgccgatatc cttacttttg caattcgggc 2326261 atataagcat acctcacacc tctatccgtt cagaacgatc tcgtctttcc gcacctcgac 2326321 aagcgaatcc gctctttgga tctggcgctt gcttcccgcc aggtcagaaa agaaaccgtc 2326381 cgagagttca tatgctacga ttatgcccct gtccaaacaa aagtatacat cttccagcat 2326441 ccccaatata tccccctctt gcgatttcac aagcttcatc ttcatctgct cgtatgtgaa 2326501 gcatgatttc ggaagaggca aaagctgttc tgaactgacc gaagccaata tgcggtcatc 2326561 aaaaatggaa gagatatcac acgcccgtaa tagcgcatga tgatgatgca aaaagcgttt 2326621 ttgtgcaaga ataaacccaa gacaatctcc tttcagagaa aaacaaatat cggaaattgt 2326681 cccgagataa ctagaagttc gttctgagta tactgggaat ccttctactt catggcatgt 2326741 tctcaaagtg tgatcaacca ccttttgttg aacaggctta ggttttgctt tgcgccttag 2326801 actcatacga tgaaatcaat tccactgcaa atgaaaaaaa actcccgctt gcacgggagc 2326861 attttattgc tgttcttctt tcataaaatc gaatggtgta atgccttcca tgccaatgtt 2326921 ggcgtcgtgt acgctgaacg ggagctcttt ttgcaaagct tcaagctcgg catccatttc 2326981 ctcaacctgt acggacagcc tgtttttcaa ggaggtctgt ctgacagttg catcattatt 2327041 tttcacgccc cactccagcg cctcctcttc cccgcataaa atgagaaatt tcttcgctct 2327101 tgtaatcgcg gtataaagaa ggtttcttct gagcattcta taatagcctt tcacaacagg 2327161 caaaaccaca atcggaaatt cacttccctg cgatttatga atagaacagc aatacgcatg 2327221 ggtaaattga ttaaaatctt ttttcgtaaa tgtcatttca ttgccgtcaa aagaaacgac 2327281 ggccatgtct tctttttctg tattttcctt tgcataaaat atcgacgtga tttcgccaat 2327341 atctccgttg aacacattgt tttccggctg attgacaagc tgcaaaattt tatctccggt 2327401 tctgtagaca acatccccga acttcaattc tctccgtttt tctttaggag gatttaaaat 2327461 gtcctgcagc atcacattca attcattaat gccggctttt cctctgtaca tcggagcgag 2327521 gacctgaatg tcctttgctg tatagccttt tttcaatgca ttggcgacaa ccttctcaac 2327581 tacttctttg atttgcgacc cgccgcagcg aataaaggaa cggtcctttg tcggggcagt 2327641 caaattgttc ggcagcaatc catttttcat ctggtgggca agctcgacga ttgatgaccc 2327701 ttctgcctgg cgatagatgt ctgtcagtct cacagtcgga atcacctggg atgccagcag 2327761 gtctctgagc acttgtcccg gaccgacgga aggcagctgg tcttcgtctc cgacaatgat 2327821 gatttgtata tgatcaggga tcgccttgaa caaatgattc gccagccata tatcaagcat 2327881 actggcttca tcgataatta acagcttccc ttcgatcggc tgatcctctg tatgagtaaa 2327941 gccttcagcg ccgttccagc caagcagcct gtgtatcgta actgcaggga gtcccgttga 2328001 ttcactcatc cgttttgctg ctctccctgt cggagcggcc aaaacaatcg gaaaagcttc 2328061 atccttttta taagctgacg ggtctagtga cacaccgtga agctctccgt agagctcgac 2328121 aatccctctg attaccgtcg tttttcctgt tcccgggccg cctgttaaaa gaagcatcgg 2328181 cgaggaaagg gctttttgaa tcgcttcctt ctggctgggg gcatactgaa cgtccatccg 2328241 ttcttccagt tctcccaacg cgagcaaaaa ctctgattcg ggaaactggt tctcatattc 2328301 ggtttggcta gcgatatgtt tcacacgctt tgcaacgttt tgttctgcgt aaaacagcga 2328361 aggaaaataa cagcggccat cttctatgac aatgtcttta ttttctccaa gggcaataat 2328421 tgcgttagcg gcatccattt ctgtaatgcg ctgcccttcc cttgctgact ggtttaacag 2328481 tgattgagtg tcgatgatca gctgttccgt ttctatgtac gtgtgcccct ctgacagaca 2328541 agtcgtttca agcgtgtaca aaatagcagc ttttacccgc tcaggatgat tacccgaaag 2328601 acccattctg ctgcccagct catccgcttt tccaaacccg atgccttcta catccttcac 2328661 aagctgataa ggattttcct gaatcttttc aagcgtctcg gattcatagg cttgatagat 2328721 tttcatagac agctgcgggc caaagccaaa ctgattcaag gaaatcatga tttgctccag 2328781 tccctgatgc cgctgcaatg cgccagccag cgtgtctgct ttcttttttg agagtctggg 2328841 aacatcataa agcactgaag catcagccaa tattttatta atggcgctgt cgcccagctt 2328901 tttcacaatt tcttcagctg tttttttgcc gatcccctcg aataaatcac tcgataaata 2328961 ttgaatgatg ccttccttag tcgttggaat ctcctttttg aaatgctccg cctgaaattg 2329021 gagcccgaat tttggatggg ttacgatctt tccgtaaaac gtgtaggtct cttcttcttg 2329081 aagcgcaggg aagtagcccg tcacggatac ggctttatct tcaatggctt cggaggtctc 2329141 tgtgactttc actttcagaa ccgtatataa attggtgtca ttatgataga tgactgtgtt 2329201 gactgtccct tttaaatagg gctcttcctc cagtttaagc tgatccggat gctgctgcac 2329261 gagctgtccc tcctcctgtg cctgttatga tggatcaatc agttttttag catgaagcgc 2329321 aagcatatga tctggctgga tatcgattgc cttgtccagc atttccagcg ctttttctcg 2329381 gttttcttta taagcataag tgacaccggc attataaaat gcatctgcat gccccgggtc 2329441 ttgctctgtc acagctgcga attggctgag cgcttcgtcc agcatgccct cgttggctaa 2329501 gcacatcccg aattgaaaac gcgcttccgt atcgttttca ttcagttcga ctgctctttg 2329561 taaatatggc agtgcaagct taggctgttc gagcttgaca agtaccgttc cgagcatgta 2329621 aaacaggtcg ccgttttcca tccccgcacg tagcgctttt tcaaacatgt ctttcgcttc 2329681 tttgtacatt tcttttacaa catagacatt tcctgctcca taataagcag tggctgcgct 2329741 actgtctaat tcaagcgctt tatcataaaa cgcaagcgca cgttccagct cgtttacgga 2329801 tgaaagaagg ttggcaaaat tgatatacgg aatcgcgtct tctttatttt cttcaatcgc 2329861 ttttgtaaat gcctctgccg ctttctcgta atcgccttcc tgcatcgcct ctataccgag 2329921 ttgattataa tccaccgatc atcttccttt cattaaaaaa ccccaactca gtgttgaggt 2329981 ttttcatctt ttatacgtac cacaattttg ttccgtcttt gtacacatca tcaattgtcc 2330041 cgccgccaag gcattcttcg ccgtcataga agacaacggc ttgtcccggc gttacagcgc 2330101 ggacttgttc atcaaagatg acttccgctt caccttcgcc agtcatgcgc actgttactt 2330161 tatgatcctc ttggcggtaa cggaatttag ccgtgcagga aatctcttcg cccttcatga 2330221 tatccgaacg tacccagctg atatttgttg ctgtgatttt gtcggaatat aaaagcgggt 2330281 tatggaaccc ttgatctacg tagaggatgt tcttttcaag atctttgcct accgcaaacc 2330341 acggctcgcc gcttccgccg atgccaaggc cgtgacgctg tccgatcgta tagtacatca 2330401 acccgtcgtg gcggcctttt acttcgccgt ccatcgtcat catatcgccc ggctgtgcag 2330461 ggagatattg gctgagaaac gttttgaagt tgcgttcgcc gataaagcag atgcctgtac 2330521 tgtctttttt cgtcgctgtt gcaagttctg cttctttggc aatttcacgc acacggcttt 2330581 tttgaagttc gccgatcggg aacatgactt tgctcagcgt atcttctgtc agctgattca 2330641 ggaagtacgt ttgatccttg ttttcatcaa tgccgcgcag cattctgact tttccgccgc 2330701 ttctgtctac tcttgcatag tggccagtcg ctaaatagtc ggcgccaagt gacaatgcat 2330761 gctccaaaaa ggccttgaat ttaatttctt tgttgcacaa tacatccggg tttggtgttc 2330821 tgcctgcttt atattcatca aggaagtatt gaaatacctt ctcataatat tgcttttcaa 2330881 agtttacggc ataatacgga attccgattt ggttgcagac gcggatcaca tcttcataat 2330941 cctctgtcgc cgtgcaaaaa ccgttttcgt ccgtatcatc ccagtttttc ataaagattc 2331001 cgattacatc atagccctgt tcttttaaca gcagggccgc cacagatgag tctactccgc 2331061 cggacatgcc gacgacgact cttgtatcct ccggccgttt ttccatttca ttcactccaa 2331121 ttactacgcc gccttattat gtcagccgtt tgacaacgtc ggccacatgt ttggcagcag 2331181 ttttcacttg ctcagccgta ttgccgaggc cgaagctgat tcgaatagag gacgtcagcc 2331241 ggtcactctc ttcgccgaac atagcagtca gaacatgtga cggcaggact gaaccggccg 2331301 tgcacgctga accgctggag acagcgacac cagccatatc aagattaacc agcagcgctt 2331361 ccactgacac accggggaaa taaagattca gaacatgcgg cagactatgc tctttgtccc 2331421 cgttgacctc gaatgccaca cctgcatctc taagcgtgtc ggcaaagatt gctttaaacg 2331481 attgatactt ctcgtttttt tcgtcacgtt cttcacttga cagcttgatc gcttctttca 2331541 gcccgacaat gcctggaaca ttttccgttc cggcacggcg ttttctttct tgctctcctc 2331601 cgaataaaag gggtgaaagc ttcacatctt tactagcata taaaaagcct gtcccttttg 2331661 gcccgttgag cttgtgcccg gaaacagaca gaaggtcaat atggctgttt ttcacatcaa 2331721 ttggcagcaa cccgaatgcc tgaacagcat cggtatgaaa ataagctttg tgttccttta 2331781 acagctcacc gatttcttcg atcggctgca ctgttccgac ttcattattt ccatacatca 2331841 ctgtcacaag gattgtatca tcacgcagtg cttctttcac ctgttttgca ctgactcttc 2331901 cattttggtc aacgtccaga tacgttatgt caaatccgtc tccctcaagt ttttcacatg 2331961 tgtgaagcac ggcgtgatgc tcaatttttg ttgtgatgat atgtctgcca agatcttttc 2332021 ttgcaagtgc ggttcccatg atcgccaagt tatcagcttc cgttcccccg cttgtaaaaa 2332081 tgatctcctg ctctgccgct ccgatttctg ctgcgatctg cgctcttgct tcatccaccc 2332141 attttcgaga ttctctgcca aatgaatgaa tactggaggg attaccgaaa ctgccggaga 2332201 agtgcggtat catttgttcc agcacgcgct catccatcgg agacgttgcg gcatgatcta 2332261 aataaatccg ttccattatg tttacacctc tgatctaaat atagaacata taagcttctt 2332321 gctctccgtc tgtatagctg gcaagatcct ctaatgttgt actgtctaaa acctctttta 2332381 cagcatcccg gatgcgaatc cagagctcac gcttggcagg ctcctcatct tccagcactt 2332441 caacagggct gatcggcccc tcaagcacac ggataatatc tcccgcagta atggcatccg 2332501 gctcactgcc taatacatat ccgccatatg cgcctctgat gcttttcact aaaccggcat 2332561 ttctgagcgg cgataccagc tgctccaaat aatgctcgga caaattattc gtctgtgcga 2332621 tgctttttaa tgaagtcggg ccttcaccgt gcttttttgc aagctcgatc ataatggtga 2332681 gcccgtatct tcccttagtt gatattttca acatgaacac ctctgttatt tcatgatttt 2332741 ccacatttat aatggtaatt tctatatgtt tcgtccgttt attatcttat agaccaactg 2332801 ttattataac ataccttcag cgaattttca ttgaggcaga aggaaagggg cctttaccct 2332861 tttctaatgt acggttttcc gttaccctgt aattaagtaa ggagagatga tagatgaagc 2332921 cattggcata tcggatgcgt ccgacaaaaa tagaggatat tatcggccag cagcatctgg 2332981 tggctgaaga taaaattatt ggcagaatgg tccaggcaaa acatttgtca tccatgattt 2333041 tgtacgggcc gcccggaatt ggaaaaacat caatcgcaac agcaatcgcc ggttcaacaa 2333101 gtattgcttt tcgaaagctg aatgctgtca ttaacaataa aaaagatatg gaaatcgtag 2333161 ctcaggaagc caagatgtcc ggccaagtga ttttgattct ggatgaagtc cacaggctgg 2333221 ataaaggaaa acaggatttt ctattaccct atttagaaaa cggaatgatc attttgatcg 2333281 gagcaacgac ggctaacccg tatcatgcca ttaatccggc gatcagaagc cggacccaga 2333341 tttttgagct tgaaccgtta acacctgaac tgattaaaca ggcactggaa cgtgcgctcc 2333401 atgatgagca tcggggcctt ggcacctatt ctgtatccat tgatgatcag gcgatggagc 2333461 attttgccca cggatgcgga ggagatgtcc gctccgcttt aaatgcgctt gagcttgccg 2333521 tgttgtcaac gaaggagtca gcagacggtg aaattcacat tacattagaa accgcggaag 2333581 aatgcttgca gaaaaaaagc ttttctcacg ataaagatgg tgacgcgcat tatgatgtac 2333641 tgtccgcttt tcaaaaatca atccgcggct ctgatgccaa cgctgctctt cactatttgg 2333701 ctagattaat tgaagccggt gatctggaga gcatcgcaag acgattgctt gttatcgcct 2333761 atgaggatat cggtttagca agcccgcaag ccggccctag agtgctgaac gctattcaga 2333821 ccgctgagcg agtcgggttt cctgaagcgc gaatcccgct ggccaacgca gttattgagc 2333881 tttgcctctc accgaaatca aactctgcca ttctggcaat cgatgaggcc ctggcagata 2333941 tcagagccgg aaaaattggg gatgtcccga agcatttaaa agacgcgcat tataaaggag 2334001 ctcaggaatt aggaagagga atcgactata aatacccgca caattacgac aacggttggg 2334061 tcgaacaaca atacctccct gatcctctga aaaataagca atactataag ccgaaacaga 2334121 ctggaaagtt cgaatctgcc ttaaagcagg tgtacgataa attaatgaaa agaaaataaa 2334181 acaaaaaaac agccttgatc atcaaggctg tttttatgca ttatttatcc ttcacacgtt 2334241 tgatttcaat gtctttcaaa agatccatga caacatgtcc gcccataatc aaacctgcaa 2334301 ctgacggcac aaaagcatta gaggaaggcg gcatttttgc tttacgtatt ttcgcttcgt 2334361 cattccccac ttcttttctg acatcttccc gaataacaat cgggctttca tcagagaaaa 2334421 tcacttgaac gccttttttg ataccctcct tgcgtaattt cgtacgaacg accttcgcaa 2334481 ttggatcagt gtgcgttttt gagatatcag cgatttggaa gcgtgtcgga tccgttttat 2334541 ttgcagcacc catgctggag atgagcggaa tatcccgttt tagacattct ttcattaaat 2334601 gaattttata acaaatggtg tctgacgcat caatgacata gtcaagacca tagtcaaaaa 2334661 actgctcata cgtttcctcc gtatagaaca tttttaacgc gatcacttca cactccgggt 2334721 taatgtctgc gatccgcgcc ttcattaaat caactttcgg ctgtccgaca gttgaaagca 2334781 gcgcgtgaag ctgacgattt acatttgtaa tgtcgacatc atctttgtcg acaagcagaa 2334841 tgcggccgac gcctgaccgc gcgagagctt ccgccgcgaa cgacccgact cccccgactc 2334901 caagcacagc aactgtgctg tttttcagcg tttcaaggcc ttcttttccg atagctaatt 2334961 cattgcgtga aaactggtgt aacaagaacc tcactccaca ttcgtattct ggtttcatct 2335021 ataaaatggc tgatccatga gcagccgttt tttctgcgca caaaaaataa agtcccaata 2335081 gtgccgttgc agctttcctt tgttttgaac ccgctctcag caggtgggtg ccctctttta 2335141 aatcttgtaa gtcctcttta ccgaatgaaa agaggcatgt acgccattta aaaatgcggg 2335201 ctcccaaatc aaaaaaatgt tcggtcaaaa ctaggtgtac aactaacaca tcaggacttt 2335261 atttaacttg tcaaaatcat atcacagacg attttgattt tcaagaatcg aactgcaaat 2335321 tcagttctta acttttttct tgatagaaag atgaagctcg tcaagctggg cgtcgcttac 2335381 ttcgcctggc gcttctgtca tcaggcagct tgcacttgcc gttttcggga atgcaatcgt 2335441 atctctcagg ttcgtacgtc cagcgagaag cataacgaga cggtctaagc cgagtgcgat 2335501 tccgccgtgc ggaggagcgc cgtattcaaa tgcttccagc aggaatccga actgttcagc 2335561 cgcttcttct ggtgagaagc cgagaagcgc aaacattttt tcctgaatat ccttttcgaa 2335621 aatacggatt gaaccgccgc caagctcata gccgtttaag acgaggtcat aagcttgcgc 2335681 tttcatgtct tcaggcgctg tttcaatcag ctcaaggtct tctcggacag gcattgtgaa 2335741 cggatggtgc gctgcgtaaa aacggccttc ttccggatca tgctctaata gcggccagtc 2335801 gatgacccat aagaaattga acaatttttc gtcaatcagt ccgcgttctt tcccaagctt 2335861 taagcgcagg gcgccgagtg atgcggccac aacttcgaat tgatccgctc cgaacagcag 2335921 caaatcacct tcagcagcat caagtgcttc aatcagctta gactgctttt cttcatcaaa 2335981 gaatttagcg atcgggcctt tcactccgtc tgcctcaacc ttcacccagg caagcccttt 2336041 tgccccgtag tttgcagcaa aagcgccaag agcgtcgatg tcttttctgg agtaatcgcc 2336101 ggcaccgcct tttacattga tggctttgac cacgccgccg tttgctacag ctgatgagaa 2336161 cactttaaat tccgtatcct ttacaatgtc agacacatcc gtcaaaagca tgtcaaaacg 2336221 cgtatccggt ttatcagacc cgtacttgtt cattgcttcg tcatacgtca ttcgaggaag 2336281 aggaagctga agttcctcac cttttgtttc acgcataacc tttgccatca tctcctcagc 2336341 caatgacata atgtcttcct ggctcataaa ggacatttca atatcaattt gcgtaaactc 2336401 aggctgacgg tccgcacgca agtcttcatc gcggaaacag cgggcaattt gataatatcg 2336461 ttcaatgcct gataccatca gaagctgttt aaatagctgc ggagactgcg gcagcgcgta 2336521 gaactcacct tcgtgcacac ggctcggcac caagtagtca cgtgcgcctt caggcgtgct 2336581 tcctgttaaa atcggcgttt caatatcaag aaacccattt tcatctaaaa agctgcgaac 2336641 agctttcgtc acgttatggc gcagctgcat cgtctggaac atagccggtc tgcgcaaatc 2336701 taagtaacgg tgttttaaac gaacgtcctc tgacacttct tcagcttgat cagaaatcgc 2336761 aaatggaggt gtctttgcag catttaatac gttcactcca tcagcatgta tttcgatcgc 2336821 gcctgttttc aaattcggat taactgttcc ctcttcacgc gccaccactt ttccttgaat 2336881 atcaagcacg tattcatttc tgatgccttc cgcaatagca agcgcttctt ttgacacatc 2336941 agggttaaaa acgacttgaa caatgcccgt acggtcacgc aagtcaataa aaatcaatcc 2337001 gccgaggtct cgtctttttt ggacccagcc tttcagcgtt acagattcgc caattgcttt 2337061 ttcagttata tcaccgcaat aatatgttct tccaaacaat gcgtttcact ccttatccct 2337121 tttggtttgc cttcatcaca tgtataaatt catcaagtgc cacttcaatc tgttcgcccg 2337181 tctgtgcatc ctttacattg attttgtttt gggcaagctc atcttcaccc aaaatcgcaa 2337241 taaatctggc ctttaagcga tcagctgttt taaactggcc tttcattttc ttattttcat 2337301 aatcgatttc actggaaatg cctgcttctc tcagtttgta caccaatgaa acagaataat 2337361 cctttgcttt ttcgccgagt gtgacgatat agcagtcgat tcccttatca acaggcagct 2337421 ctcttttttc agcatcaatt gcggcaagca agcgttcgat gctcatcgca aatccgatgc 2337481 ccggtgcttc aggtccgccg atctgttcga caagcccgtc gtagcgtccg ccgccggcaa 2337541 gtgtcgtaat cgcgccaaag ccctccgcat tgctcataat ttcaaatgcg gtgtggttgt 2337601 aataatccag ccctctcaca aggttcggat cgatttcata cgaaatgcca agatcattta 2337661 agtattgttt cactttttca aaataagcgg ctgattcttc atttaaatat gtcaaaatcg 2337721 aaggtgccga tttcatcagc tcatgatcac ggtctttttt gcagtccaaa attctaagcg 2337781 ggttcgtgtg cagccgggac tggcagtctg aacaaaattc ttcgatgcga ggctcgaagt 2337841 gtttcacgag cgcttctctg tagcttttgc ggctatcttg atcgccgaga ctgtttatga 2337901 caagcttaac gttttctaaa cctgcttttt cataaatact catcgcaagc gccattactt 2337961 cagcgtcgat tgcagggtct ttcgaaccaa tcgcttcaat tccaaactga taaaactggc 2338021 ggtaacggcc cgtctgagga cgttcataac ggaacatcgg cccgacataa taaagctttg 2338081 tcggctgtac aggatttgcg aacagcttgt tttcattaaa agcgcgaacc gcagcagctg 2338141 ttccctccgg acgaagcgtc aggcttctgc ctttgcggtc ctcgaaggta tacatttctt 2338201 tttgtacgat atccgttgat tctccgacgc ctctggcaaa cagttctgta tgctcaaaaa 2338261 tcggtgtgcg gatttcttta tattgataag tgcggcaagt gtctctcata atttgttcaa 2338321 caaactgcca gcgatctgat tctccaggca gaatatcctg tgttcctctc ggaatgttat 2338381 atcccatagg tagacctcct tatgtattcc ttataaaata tccaatgatc gttaatgatg 2338441 aaaatgaaaa aaactcccgc ccctactata catgatagta gggacgagag ttatacccgt 2338501 ggtgccaccc tagttggaat acgttcatat tcccgctcga tcctttaacg caggttcacg 2338561 ttcactgcct aatggcgtta ttcacgcgtt cagcaggaaa cctccggagt gttgtttcga 2338621 gaaagacgca atgggatccg ctttcagcct ggggcgggtt cctctctaat catgcaatct 2338681 gacctactct tctccattat tggttcaaat ctttcatcat ttgctatgta ctcaatttct 2338741 attataataa tgggattggg gttctctgtc aagctttatt ccggttgttt ttcctcagcg 2338801 ctgcttcttt ggacataaga ccaaattcag atgctgtttc cgtaagataa ccagtcgtat 2338861 cgggatctgc gtgatcgctg taatgcagat tcgcttcacc gtcgtgaaat gcacgtccca 2338921 tttttggatg atatttcatg atttgcacac ctttttgatt gtatttacgc ttagtataaa 2338981 caaatcattt tatttttatt taaaaatcag aaaggacttt acgatattaa acaagaatgc 2339041 ttttttaatg atcatcagaa aggaggacac aatgaacaag aaatactttg tccttattgt 2339101 atgtattatt ttcacctcag cgctattccc gaccttttca tccgttacag ctgctcaagg 2339161 agaagcggtc atcgcaacag atgaaatgaa cgtcagaagc ggcccagggc ttagctacgg 2339221 cattacagcg gaagtaaaaa agggagaacg ctatccaatt ttaaaggaag atggagactg 2339281 ggtgcagata cagcttggtt ctggagaaaa gggctgggta gtctcctggc ttattacaaa 2339341 ggaagaccag gccagcacaa gctcctcagg aagcagtgac actgtgacat caacagaccc 2339401 cgatctgcgg atgagaagcg gcccgggcac ttcctacgaa gtcatcggca aattcccgca 2339461 aggcagccaa gcatctgtca ttgataaaga ttcgggctgg atcaagatat cctatcacag 2339521 tgccaccgga tgggtatcat ctgaatatgt cacatcagga ggcagcagtt cagcgtctga 2339581 tgagagtgac caaaccgagg attccggtgc gtcaacgacg ggcacagtcg gtgtttcttc 2339641 gctaaatgta agagcctccg cctcacatga cgcggcaatt ataacaaaac ttgatcgcgg 2339701 aacgaaactg acggttctca acgagaaaaa tggctgggct cacattgagg tgaacgggct 2339761 aaaaggctgg gttgcaagcc attacctttt gactagttct gttccagctg atgattcagc 2339821 aaatgccggc agttcatcct ccgctaaaaa agcctatatc atgtacggag gaacgaatct 2339881 aagaagtgat gcgtcaacat cagcttcgat cgttgagcgc gctgccaaag gagattcata 2339941 caccattacc ggttcaaagg gaagctggta tgaaataaag cttgataacg ggcagactgc 2340001 ttatgtagcc aattgggtgg tccaaacgtc taaaagcgca gaagaagcag gtgaaccgcc 2340061 agtctctgat tccccgtctg gaaacggctc tctaaacaat aaaacgatta ttgttgaccc 2340121 gggacatgga ggaaaagaca gcggaacgat cgggtattcg gggaaattcg agaaaaacct 2340181 gacgatcaaa acggcaaaac tgctcgccag caaacttaga tcggctggag cggatgtata 2340241 tgtgacacgc caggatgata cctttgtcag cctgcagtca cgggtctcta cctctcacta 2340301 ccgtaacgct gacgccttta tcagcattca ttatgacagc tatgcggata cctctacaag 2340361 aggcagtaca gcatattact acagtcctgc caaagatcag gaactcgcat cagatgtcca 2340421 ctcagaagtg gtgaagcgtt cttccattcc agaccgcggc gtattattcg gagattatta 2340481 tgtgctccgg gaaaacagac agcccgctat gctgtacgag ctgggatatg taagccatcc 2340541 gcaggaagaa gccattgtac atagcaattc ataccaagaa aaagtaacag atgggatcga 2340601 aagcggatta gagaaatact tccaataaaa aaagctgcct tttggcagct ttttttattt 2340661 tgaatccata atgagcgtga ccggtccgga gtttgtaagc tgaacatcca tcattgctcc 2340721 aaacgttccg gtctccactt tgattccttt ttcacgaagc aggtcattcc atttttcata 2340781 aagacctaaa gctttatcag gtttggccgc gttcatgtag ttcggccggc gccctttttt 2340841 cgtatctcca taaagcgtaa actgtgagac ggataaaatc tctcctccta tatctacaag 2340901 agacagattc attttccctt cactgtcatc gaaaatacgg agattgacaa ctttatcggc 2340961 taaataagct gcatcatctt ctgtatcatc gtgagtgatg ccgaccagca ccataaggcc 2341021 ttgtccaatt tggccgacga cctcttcgtc cactgtaacg cttgcttctg ttactcgctg 2341081 aacaactaat ctcttttcta acccctttag ttcatgacgc ggcgcacaga atagatatct 2341141 ctaatctgtt taatacgctc gacgacttta tgcaagtgat tgatattctg gataaaaatc 2341201 gccatatgga tggttgccac tttattgcga tccgatttgc cagagacaga tgaaatattg 2341261 gttttcgttt cattcactgc ctggagtacc tcgttcagca atccgcggcg gtcataccca 2341321 agaatctcta tctcaacatt gtattccttg cgcttttgaa cttgtgactc atgttcccac 2341381 tctaccggga tcagccgctc ttgggcttca ttcgttttga cattcggaca gtcttcgcga 2341441 tggaccgaaa cccctctgcc ttttgtgata aagccgacaa tatcatcacc tggcacagga 2341501 ttgcagcatt ttgataaacg gacaaggagg ttgtcaatgc ccttgacacg aacgccagct 2341561 tcccgttttc ttccttgcgg gtatggctta ggttccccag tgacttcctg aacgatcttt 2341621 tcctgttctt cctggtcgcg ctgctttctc tctttttctg ttaggcggtt cgccacctgc 2341681 agagctgtga tgccgttgta accgaccgcc gcgtacatat cctcttcatt tgagaaatta 2341741 aatttgtcag caaccttttg aatattctcc ggcgttaaaa catccttcaa ttcaaaatcc 2341801 aagtttttaa tttctttttc gaccagctca cggccttttt cgacattttc ttcacgccgc 2341861 tgtttcttaa agaattgacg gattttatgc ttcgcttggg atgtttgggc aagcttcacc 2341921 caatcctggc tcggaccgta ggaatgctta gaggtgagaa tttcaacgat atcacctgtc 2341981 cgaagcttat ggtcaagcgt aaccattttt ccgtttactt tggcaccgat tgttttattg 2342041 ccgatttcag agtgaatccg gtaagaaaag tcaatcggaa cagaaccgga cggaagctcg 2342101 attacatctc cttttggcgt aaagacatac accatgtcag agaacaaatc aattttgagc 2342161 gattccataa attcttctgc atctgtcgat tcattttgaa attctaaaat ttcacggaac 2342221 caagaaagct ttttctcaaa ggttgcacct tcattggctg ctttcccttc tttataagcc 2342281 cagtgagccg caaccccgta ttccgctatt tcatgcattt caaaggtgcg gatctgcact 2342341 tcaagcggat cgcctttagg cccaataacc gttgtatgaa gcgattgata catattcggc 2342401 ttcggcattg cgatataatc tttgaatctg cctggcatcg gtttccagca tgtgtgaatg 2342461 atgccaagca ccgcgtagca gtcctttatg ctattcacaa gaatacggac agccaacaaa 2342521 tcgtaaattt cattgaattg cttattttgc agcaccattt ttcgataaat gctgtaaata 2342581 tgtttcgggc gtcccgagaa gtcagccttg atatttactt cttcgacacg tttcttcact 2342641 tcattgacaa cctcatcgac ataaagctct cgttctgcac gtttcttctt catgaggttg 2342701 acaattctgt aatattgctg agggttcaaa taacggagcg ccgtatcttc caattcccac 2342761 ttaatttttg aaatcccgag acgatgcgcc aaaggagcaa aaatttccag cgtttcattg 2342821 gagattctcc gctgtttttc ctgaggcaga tgtttcagtg tccgcatatt gtgaagacga 2342881 tccgccagct tgatcaatat gaccctgata tcttgagcca tagcgacaaa cattttgcga 2342941 tgattttccg cctgctgttc ctcttgagat ttatatttaa ttttgccgag tttcgttacg 2343001 ccgtctacaa gcattgccac ttcttcggaa aatgcttctt tcaggtcatc gagcgtcaca 2343061 tctgtatctt ccacgacatc gtgcaaaaat ccgcccgcga ttgtggaagg gtccatttca 2343121 agatcaacga gtatccccgc aacctgaatc ggatgaataa tatatggctc gcccgatttg 2343181 cggtattgct cgcgatgagc atcttcagcg tacagatatg ctttttcgac aaatgcgata 2343241 tgctcatcag atagatagct gcgtgcttta tctataactt gctcggcagt caatacttgt 2343301 tcgttcgcca tggaatcacc ttttttaaaa tgtaaactgt attgtagttt attatcaaga 2343361 aaaaaacgaa agatgtaaag agcagaagtt caaatagcca aatattatat aaaataaatg 2343421 caaaacaata ggaaaaaagc accctgacat ggagtgcttt ttcgttatgc ggttatcctt 2343481 agtatttcat caatgttaag atgtcgtaat cttcgagctt atttctgccg tcaaggtaag 2343541 aaagctcgat taagaaagcg ataccagcaa caacgccgcc aagttcttca acaagtttga 2343601 ttgtcgcttc aattgtgccg cctgtcgcaa gcaggtcatc tgtaataagc acacgctgac 2343661 caggcttaat cgcatctttg tggatcgtta atacgtcttt tccgtattcc aagccataat 2343721 ccactttgat tacttcacga ggcaacttgc cttctttgcg gaccggcgca aaacctacgc 2343781 caagcgcgta agcaacggga cagccgataa taaagccgcg cgcttcaggg ccaacgacca 2343841 aatcaatttg cttttctttc gcatattcaa caatttgatc tgtggcatag cggtatacat 2343901 cgcctttatc catcagtgtc gtaatatctt taaattgcac gccctctttc gggtaatccg 2343961 gtacaattgt tacgtattgt tttaaatcca tctgttttat gtcctcctcg tactttcata 2344021 agcctctgaa tcttgtttca tcagcttatt cagccattcc ttcagctctt cagcagaaga 2344081 ataattcagc ttttgatcca gttccatcag ctgctgtttc gcctgatatg tttgtgagtc 2344141 tgttaagtcg cgtttctttg ctccgctcac aacagacagc acaccattct ctattttaac 2344201 aaaaccgaga tcaaaaaaca cctttgtcat gaaattgatt gtttcaacgg accagccttt 2344261 atgttttgca agctctgaac cgtgtttttt cacgtcaaaa gcgcctcttt tcagcaagaa 2344321 cgcataatac catttaaagt ggtctcttgc gggaaaagtt gataaaaagt ggtcctcatg 2344381 attgagaaaa ataaaatata tccgctcggg cgcctttcct tccagcaaac gtgcgagcat 2344441 gtccagcgaa ggcggcggat ccagtaatac aatatatgca ccatcgaggt caaacgcctt 2344501 tgcttgatct ttagaactga tgacgtgcac ttctcggcga aggtcttcag tttgaagtaa 2344561 tgttgttgag tcttctttga aagagacaat ggcccgttta gcagatggaa gggcggaaac 2344621 tgtgtcttcc cacgtccgtt ttccccttaa atcaaacagc tgccattcag aaacagcggc 2344681 atcctttatc ataagctgcg gcttttttcg attgttccat tcgttgattg acatctcacc 2344741 gacaatggaa attcttgaac ccggtacgat gccttcttga agctcgcctt tattaaaacc 2344801 gacgcaatca agctgggacg actcgtttct gatcgtcatt ttgacatgag ttttatttgc 2344861 ccctatcttg cggacatctt ccagtactgc attttctacg agaacgtgcg gtttcgggtt 2344921 cagcatgcca aaaggagaca gcatgttcat ttctgcgatg ctttcaactg taatgtcttc 2344981 gacgccgcag acaaggtcga cttcctgtac gggaataaaa tcctcttccg taagcgtatt 2345041 gtccgctatt tcattcagcc tgcttcgcaa atccggcaca tcttcggctt tcagcgtcat 2345101 ccccgcagcc attggatggc cgccgaaatg aggaagaata tctctgcatt cagaaaggct 2345161 ctcaaataaa ttaaatcctc tgatgcttcg ggccgaacct ttagcgattc ccttttcttc 2345221 atcaatacca agaacaatgg ccggtcggta gaaacggtcc acaagctttg aagccacaat 2345281 cccgacgact cccgggttcc atccggcttt ggccacgaca attgcagttt gatcgagccc 2345341 ttgctgttca accatttcaa tcgcttcatc cgtcattttg ctgaccattt tttggcgctc 2345401 tttgttcagc tggtcaattt ctgcggcaag ctcttccgct tcaaacgaat cctctgacat 2345461 aagcaaatga acagcgggat ccgcctgttc gattcttccg acggcattca gccttggtgc 2345521 gagctgaaat ccgactgttt cttcgttcgc ttctccgatg tctccgcctg acagcttaat 2345581 cagctctttt aagccgagcc gatttgtccg tcgaagcctt tcaagtccta gtgttgctat 2345641 taatctgttt tcgtcatgca gcgggactag atcggcaatg gtgccgatag ccgccaggtc 2345701 aagcagttca tcaggaagtt cacccaataa agcgtgggca agcttaaacg cgactccaac 2345761 cccggcaagc tctttaaacg ggtaagtgca gccaggctgc ttcgggtgga cgatcgcacg 2345821 gacatccgga agctccggtc ccggttcatg atgatcggta atgatgacat ccagtccgag 2345881 ttcctttgcc accttcgctt catgcacagc ggcaattcct gtatcaaccg taatgatcaa 2345941 agagaagccc cgttctttaa tcgaacgaaa cgcctgttca ttaggtccat atccttcttt 2346001 aaaacggtca ggtatataaa aatcaacttg agccgacagt ttttgcagcg tgtgaagcat 2346061 cactgacgta cttgtaaccc catcggcgtc ataatcgcca tatatcataa tcttttcttg 2346121 ttgtgaaatc gcctgtttta ttcgatctgc cgcttctttc atgcctttca tttcaaaagg 2346181 atcataaaaa tcggcatcct ttgtatgtaa aaacagccta gcgctttctg ccgtatcaaa 2346241 gcctcttttt acaagcaggg acgcaacaag aggtgttata tgcaattgtt ctgtgagtga 2346301 tttgacctta tcctgatctg gtcgctggat ttcccatcgc atttttgacg ctaacataaa 2346361 ttcacccctc aaccacccta ttatactaga gcaggctgag gggtttcaaa taatattcga 2346421 aaactagtct tttttctcaa tcatggctga tgcatcctgt gtgtcagtct gatcagcaag 2346481 atgagtatcc tcttgtttat gtattgctgt tctattttct ttccgcaagg tttttatttc 2346541 ccgcttcaat ttcattacct gaaaaatgcc gacagaaaat acgatcagtg ctcccattaa 2346601 aactgagccc aaaataacaa gaatgagcgg ccattctgat cttccaaaca ggtaatcaac 2346661 ttctacggat cgaacattaa tgactgcgaa aatagcgaca attaaggtga aaataagtgc 2346721 gaaaataatg gtccattgtt tattcattct cttttccccc aaacttctta ttgaggtaac 2346781 tttcccaatc aagactggtt ttaaacatgg cttaacacta ggttaagctc cctttgctgt 2346841 taatttttcc cggatcagcc tcttcagtcc ggttccctca ccggaaatca caagtgtatc 2346901 gccttcgtca atgactgttt cagagctcgg attcagttgt ttatcctgat tctttttaac 2346961 aattgcaatg accgtcacat gatattcctg acccacattc aaatcaccaa tcgtctgatg 2347021 aatggcaggc gctcccgcct ctgctttaca ccactctata atcaaatcat caagggctga 2347081 ctcgacctgt tctaatgctt tcggtttata tgccattccg ccaagaattg cagacatttg 2347141 ccttgcttca gcgtcatcaa actgcacgga ggcaacacat tcctcatggt cgttttcgtc 2347201 aaaatagtaa agctctctcc gtccgtcatg atgaatgata attgaaattt tatcacggtt 2347261 tctagtaatc atttcaactt tttgtcctat gcccggcagc tctgattcgc gaaccctcat 2347321 atataaaccc tcctacatat ctgaaaacca gccataaaca cttttaacac catatatatg 2347381 tttaaatgta agcgtatgtc attatagcaa atgtctattt taagttcaat gaaacttcaa 2347441 aaaacaggct gccctgcaga ggacagcctg atatttttta ttgcgccgaa tcttttttca 2347501 gttctcttcc tttccatgca agccaaattt gtgcggcaat gtatagagaa gaataaacgc 2347561 ctgttaacag cccgaccaat aaagcaattg agaagttagt aatagaagat gctccaaaga 2347621 tcagcaatgt cacaacaaca atcacaacgg ttaatacagt gttaattgaa cgtgtaaagg 2347681 tttgctgcag gctcaggttt acaatatggt tcagatcggc aaaggttttc ggcttacgct 2347741 ttttcatatg ctcgcggacc ctgtcaaatg taacgattgt atcgttaatg gaatacccga 2347801 ttatcgtcaa gatggccgcg atgaatgtaa catctacctc aagccttgta atactgaaga 2347861 acgtgacgat aaagaatgcg tcatatagca atgaggcgat ggcagcaatc gccattttgt 2347921 attcgaatcg gattgaaacg taaataatga tgccaataga agctatagca actgcgtaca 2347981 gcgcatttct cgccagctcc ttaccgactg tcggtgaaac tgtgctgaca tttggatcag 2348041 atccgtattt gtctttaaaa tacgttttta cttttgcaat ggtttcttta tctggcaccc 2348101 cgacaaaacg ggcaacaccg atattgctct tttcgcctga cagaactaca gtatcagggt 2348161 ccatacccag agattcaaaa tccttctcaa cttgctctgt cgtcagctta tggtcgcttt 2348221 gcacttcaat ccgtgcaccg cttgcaaagt caatgccaag attcagcctg aacacaagca 2348281 ggataataat cccggcaacc gtgaccgcac tggagaaaat aaagaagtat ttgcgtttgc 2348341 tcgtgaaatc ccatttttgg aatggcgtat gcggctctgt attttcatcc gtatcctgaa 2348401 tatccatgat atgtttctta ttgacaccaa accagccttt tttccgatca agccatctgc 2348461 tttccacaag gagagcgagg agaaatctcg ataagaaaac ggcagtgata aagcttgtca 2348521 aaatcgatag gatcagcatt gtcgcaaacc ctttaacaga gcttgtccca aagataaaga 2348581 gcacaaccgc tgcaataatg gttgtaatat tcgcgtcaaa aatcgtcgca aatgaccgtc 2348641 tgtttcctga acggaaggca gagcggactg actttcctag cttgagctct tctttaatcc 2348701 gctcataggt aataatgttg gcgtcaacag ccatcccgac acctaaaatg agagcggcaa 2348761 ttcccggaag cgtgagtacg gcattcatcc agtcaaagat ctggagtgta atgtagatat 2348821 aaacagacag cgtaatcacc gcgattaatc ccggcagacg gtaatagaaa agcataaata 2348881 agaaaataat tgcgataccg acaataccgg caaacaccgt atcatggaga gcctgctggc 2348941 cgaattgcgc gcctactgat gtcgaatact tttcagtcag tttcacagga agtgcgcctg 2349001 cgtttaaaat gctggctaaa tctttcgctt cttgagctgt gaaatgacct tcaattttta 2349061 catcagttgt atttagttcc tgacttacat ttggagcgga tacaaattta ggatgctctt 2349121 tttgaacttc tttcttaaag gaatcacctt tatcataatc caaccaaatg acaagctggt 2349181 tgtttggcgc cattttcatg accttcttgg tcacttcacc aaatttatca gcgtctttca 2349241 gcttaatcgt gacaattggc tcatttgttg tgctatcata agtttgttta gcgccgtttt 2349301 cgactagatc agcaccgttt aacagttcct tatcatttgc atctctgaaa gaaagctgcg 2349361 cttcagtcgc caaaatttca cgcgctctgt tttggtttgt cacgccagcg agctgaacgc 2349421 gaatccggtt attcccttca atttggatgt tcggttcgct gacaccgaga acattggccc 2349481 ggcggttcag tgcctctact gtgctgacca gaacgtcttt tgtgattttg tcaccttttt 2349541 ttacaggctg tacatcatac agcacctcaa atccgccttg caaatccaat cctaacgtaa 2349601 tattgttagc ggcaggcttc gtaaagtagc ccaagcccgt gccgatcaat agaacgaaaa 2349661 ggaaaaacgc aatcaagcgt ccttttttca ttatgtatat cctcccttaa acctgtgcga 2349721 atcaacctgc tatctcagca gttcttccaa tgcttcctgg ccctcttcac tgcccagcca 2349781 attagacgtt ttaaatgact caacggttgc atagttcata aattcgccaa ttttcactga 2349841 taaaatatca ctcgccagtt cataaatgct cagttccgtt ttctttttcc acttcttatc 2349901 tgttaagtat gaccacaaac tttcgagttc aacatcatca tacccgagaa tcttaaactc 2349961 ttccagtttg ctgtaaagaa acggcctgac gtggtcttta tatagatcgg ctggatgctt 2350021 ctccacgaat tccacgctcc ttttttattg tttttcaaga agacttgtca tgcttggacg 2350081 acatatacgc atatctttat tgtatatgat tccaggtagt ttgagaaggc agggggtaaa 2350141 aatggcgaaa cagacgtttt taaagggcac tcttatcctt atcgcagcag gaatggttac 2350201 aagaatgctc gggtttgtca accgggtggt tatcgcccgt tttatcggtg aagaaggagt 2350261 cgggctttac atgatggcag cgcctacttt cttcttggcc actacattaa ctcaattcgg 2350321 tctgccggtc gcgatcagca agctagtcgc tgaagccagt gcgcgcggag atcatcaaaa 2350381 aacgaaaaat attttagtca tgtctctgac cattacggga gtgctcagcc tcatctttac 2350441 accgctgttt ctgtttttcg cccctgttat ggctgaaacg atgctgacag ataagcgaac 2350501 actgtatccg ctcttggcca ttacgcctgt tgtgccgatt attgctatat cgagtgtgct 2350561 gaggggatac tttcaaggaa aacagaatat gaacccgctt gctatgtcac aagtccttga 2350621 acaggttgtc cgcatttcac tcgtggctgt ctgcacaacg atttttctcc cttacggaat 2350681 tgaatatgct gcagcggggg caatgctatc ctcagtggca ggggagctgg catcacttct 2350741 ttatttattc gtttgcttta agtataaaaa gacaattaaa atcagaaagc attttttaca 2350801 gtcaattaaa aacggaaaac aaacctttac ccaattaatg agcgtgtccc ttccaacaac 2350861 cgggagccgc tttatcggaa acctctcttg gtttttcgag ccaatcgtcg tcgctcaaag 2350921 ccttgccatc gccggtgtgg caacagttgc cgcaacaaag caatacgggg aactaaccgg 2350981 ctttgccatg acgctgctga ctctgcccag ctttattaca tattctttgt cgaccgcgct 2351041 tgttcctgcg atcagtgaag gaatggagca gaaaaaattg caggtggtgg aataccgctt 2351101 agaacaggcg atgcgtctct gtctgctcag cggaggcatt tcagttgtta ttttatttgt 2351161 atttgcggat gagctgatga gagtgatgta cggttcctca ggcgcagctg tatttataaa 2351221 agtgatggcc ccgttttttc tgctttatta tttccaaggc ccgcttcaag ctgtgctgca 2351281 ggcgcttaat ttggcaggag ctgcgatgat gaacagctta atcggagcgc ttgtcaaaac 2351341 aggccttatt tttgtccttg ccacaaggcc ttctcttggc attatgggcg cggcattagc 2351401 cattgtgaca ggcatggtgc tcgtcacgct attgcacgca gcaaccgtaa gcaaagtgct 2351461 gccgatcagc atcaaaatca aggagtacgc gctcagcttc gctgttattg taatttgcgg 2351521 attcatcagc tccgccatca aacaatatat aagctttgga gcatctgagg ctgtcaatct 2351581 agccggatgg attgcggcga gcgccgccat ttatatgatc ctcctgctcg ttttccgttt 2351641 aattaaaaaa gatgagcttc gccgcattcc cattatcgga cggttgatca tccgataatg 2351701 gtcacgtgcg gtgcccatct ttttcatcaa tatatatttc tccgtctgta aacgagcaaa 2351761 atgaaatatc tgaagggttt gtgtatccgt gtttttgcaa actttcaagc agccattttc 2351821 tatctttact gattctggac aggttttctg tttgaatgaa gccgtctata atgagcggca 2351881 tttcgagctg ccgatgctct ccgctgtttt ctttcttaac aatagtcagt ttgcccgacg 2351941 gctctaaaat agcaaatgat acgtcagcta ctctgtcgat gctattttct ctgagctgaa 2352001 ccattaaatc atcaaaatta taacgctgtg atttcatggc ttcttcgtca atttttccat 2352061 atttgataat tatggtcggc ttaccgtcaa gaagctggcg gacttttcgg ttttttaaag 2352121 aaaagtatgc caaagtcact tgaatgatca ttaatacaag cattggcaaa atggtatgaa 2352181 atagatgatc gtctacgttt tctatggcta aaacggcaat ttcagccatc atgataaaga 2352241 caacgagatc taaaatacta agctctccga tctcccgttt gcccatgaaa cgaaaaatga 2352301 ccaatatcac aaaatacaat acgactgtgc gaaacgcaat agtgagaagc tcttccatta 2352361 tgcacctcca actcattata ggttgcaaca aaatgatcaa tttatgtaag aaaaaccgat 2352421 tgcatttcac aaagctttta cgtctaattc atgggataag ggaatacatt tttacaaaga 2352481 cgagccatca gcatgtctga cggttttgaa caaaaagaac agaagccttt taatacaggc 2352541 agagaggaga caatcatgga ggaaacgaaa caagttggaa aaggcattct ttacggctta 2352601 atcgccatat tttcagccat gctcctgaca agtttagcgg tttcactttt attgaccgca 2352661 acctcgctgg aagaatcatc atttaactgg ctgatcaccg ctatctcatt tctctcttta 2352721 tttatcggcg ggttcatttc aggcgggaaa ggcaaggaaa gaggctggat gattggcgca 2352781 ttgaccgcct taagtttttc tctgattatc ttattgtttc agtatttagg attcggaaag 2352841 acatttacag cagaacagct gatcttccat ctgggatttt taggggtgtg catgctgggc 2352901 gggattttcg gcgtgaacat gaggggaaac aggtcttcca cataaaaaag agcgggctca 2352961 cttgcccgct cttttttgtt tgctatgtat agctcctgct gttattcagc agcagaaact 2353021 tctctgatcg cgcggcggtc gaacgtaaga cgtgtgttat caccagtctt aattacgact 2353081 ttgctttcgt cgatagagtc aacagtaccg tgcaatcccc cgattgtcac tactgaatcg 2353141 ccttttttca gttcctcttg catttggcgt acagcctttt gctgcttttg ctgaggacga 2353201 atcagcaaga agtaaaggac cgcaaacatt aaaataatag gaaccaatgt acctaaagtg 2353261 ccagtcatca ttttcacccc tttctgtaag cctgttatgt ttatttagaa gcttttcgca 2353321 tttggcttgt tatagccgta acgctcaaag aactcttctc tgaaatcacc cagacgatcc 2353381 tcgcgaatag cctgtcttac ctgctccatt aagtgtaaca gaaaatgaag gttatggtaa 2353441 gttgttaatc gaaggccgaa tgtttcattg cagcgaatca agtgcctaat gtacgcgcga 2353501 gtgtagtttt tacatgtata gcaatcacac tcttcatcaa tcggacggaa gtctctttca 2353561 aatttcgcat ttttcatatt gagtcgtcct tcagcagtaa acactgtgcc gtttcttgca 2353621 atccgtgtag gcagcacaca gtcaaacata tcgaccccgc ggatcgctcc gtcgatcagt 2353681 gcgtccggag aacctactcc catcagatat ctcggtttat ccttcggcaa gagcggtgtt 2353741 gtgaattcga gtacacggtt catgacatcc ttcggttcac ctacagacaa tccgcctata 2353801 gcatatcccg gaaaatcaag cgaaatcaag tccttcgcac tttgtgtccg cagatcttca 2353861 tattctccgc cttgtacaat accaaacagc ccttgttcat cctgacgatt gtgggcattc 2353921 aggcagcgtt ccgcccagcg gcttgtccgt tcaactgacc tcttcatgta gtcgtactcc 2353981 gccgggtatg gcgggcattc gtcaaacgcc atcataatat cagagccgag tgcgttttgg 2354041 atctccatcg ctttttccgg agataaaaac agcttgtctc catttagatg attgcggaaa 2354101 tggacaccct cttcctctat attacgaaac ttgcttaaag aaaagacctg aaaaccgcct 2354161 gaatctgtta aaattgcgcg gtcccagttc ataaatttat ggagcccgcc cgcttctttg 2354221 acaatgtctt ggcccggacg aagccataga tgataagtgt tgctcaaaat gatgcctgca 2354281 tccattgctt tcagctcttc aggcgacatt gttttgactg tcgccagtgt gccgaccggc 2354341 ataaaaaccg gcgtttcgaa ggagccgtga ggcgtatgca ctttgcccag ccgcgctcct 2354401 gtttgtttgc attcttttat aaattcatag cgtattggtt gttcagccac ttttgatgag 2354461 gcctcctgtt ctcaaattat ataatcagca tcgcgtctcc gaagctgaag aaacggtatt 2354521 cctcttccac tgcatggtta taggcacgca gaatgttttc tcttccagca agcgcgctga 2354581 ccagcataat caatgacgat ttcggcaaat ggaagtttgt aatcattccg tcaatggctt 2354641 taaattcata gcccggataa ataaaaatag atgtccagcc gcttgatgct ttaaattgcc 2354701 cgtcatgttc tccggcaatc gtctcaagcg tgcgtgtcga ggtcgtgccg acagaaatga 2354761 tccgaccgcc attttctctt actttgttta aggctgcagc cgtttcttct gacatttgat 2354821 aaaactctgc atgcatatta tgctcttcca cttcatcggc actcacaggg cgaaacgttc 2354881 caaggcctac gtgcagtgtg atgaactcaa tttgcacgcc tttgtctttc agctgctgta 2354941 agatttcttc cgtgaagtga aggccagctg taggcgcagc agcagagcca atttcttttg 2355001 aatacactgt ctggtagcgc tctttgtcat caagctgttc tttgatatat ggagggagcg 2355061 gcatctctcc aagggattca agcacctcgt agaaaatacc gtcatattga aattccatct 2355121 ttctgccgcc gtgctcaagc tcttccgtgc agattgcctt caatcttccg tctccaaatg 2355181 tgacaacagt tccttttttc acccgtttcg ccggtttggc aagtgtttcc catttatcac 2355241 cggtttcctg tttcaacaaa agaagttcca ctttcgcgcc ggtatcctct tttgtgccga 2355301 ataaccgcgc aggcagtacc cgggtattgt tcaggactag acaatcgcct tcgttaaaga 2355361 agctgataat gtgtttaaac gagctgtcag taagctctcc tgtatgttta tcgagcacca 2355421 tcagccttga agcatcacgc tgctccaacg gtacttgtgc aattaaacgt tctggtagtt 2355481 caaaatcaaa taaatcgact ttcatgatga tttcaccttt attctagtct tttgttattt 2355541 cattctgcca aaaagattaa gcaaaattga taataccaca cttataataa tacaagtgac 2355601 aaccgggaag aaaaacgtaa catttccttt ttttacaaaa atatctcccg gcatcttgcc 2355661 gacaaaatgc aaaactgctc cgataataag caaaacagca ccaagaatca taatgatctt 2355721 aggaaattca gtcatatcgg ggagcctcca tttggaaatg atgataaacg gccggtgtca 2355781 cgatccttcc acgcggcgtt ctttgtataa atccaatttg cagcagatat ggttcatata 2355841 cgtcttcaat cgtatgcgat tcctcgccga tggtagctga aatcgtatca aggcctactg 2355901 ggccgccgtt gaatttttcg atcatgccca tcagcagctt atgatcaata tgatccaaac 2355961 cgaggcggtc aacctgaagc cgctccagcg cattctgaga aatgtcttcc gtaatcctgc 2356021 tgtcacccag cacttgggcg aaatcgcgca cccttctcag caggcggttc gccacgcggg 2356081 gcgtccctct cgatcttctt gcaatttcaa gagccgacgg tttatcaatc tcaacctcga 2356141 atacatcagc ggttcttgtg acaatatccg ccagttcttc ttgtgtatag tactcaaggc 2356201 gagacattac gccgaatctg tctcttaaag gagccgtcaa aagccccacc ctcgtcgtgg 2356261 ctcccaccag cgtaaaaggc ggaaggtcga ggcgaaccga gcgggcagat gggcctttgc 2356321 caatcacaat gtccaggcaa aagtcttcca ttgcaggata aagcacctct tcgatcgatc 2356381 tgtgcagcct atgtatttca tcaataaata atacatctcc cggttccagc gccgttaata 2356441 tagcagccaa atcaccaggc ctttcaatcg caggccctga tgtcgtccgc aattccactc 2356501 ccatttcatt agcaacaatc gaagcaagcg ttgtttttcc gagtccgggc ggcccgtaca 2356561 gaagaacatg atccagcgtc tcctgtctca ttttcgccgc atctataaac acgcgcaaat 2356621 tttcttttac cttatgctgc ccgatatact gtgccagatt ttgcggcctc aggctttgct 2356681 ctatcactga ttcatggttg tctgcttcac ttgagacgag ccgttcatcc atgaacatca 2356741 ccttacttta atagtttttg taatgctttt ttcacatatt ggtctgttgt cagcccaatt 2356801 tcttctttaa ggtgaggaag cacctttttg atttcttttt cagcatatcc gagaaccctg 2356861 agggcttcaa gtgcttcttc aagagccgtt tccgctgttt gcttttcaag cctttcttca 2356921 tgattaaaca gattttcaat catttcaggc acaacatctg ccagctttcc ttttaaatct 2356981 agaataatct ggcgtgcggt tttctttcct actccaggaa acttgaccaa aaaagcttca 2357041 tcttcatttt caattgcttg gatgaccgct ccgggatcac ccgagcccaa gatggcaagt 2357101 gctcctttcg ggccaattcc ggtcacgttt aacagctttg taaagagcgc cttctcctct 2357161 cttgttgaaa aaccataaag cgaaaaagca tcctctctga tatgatggta tgtaaaaatc 2357221 gtttcttggc ttctctcctt atatataaac ggattcggcg tgaaaatctg atagccgatg 2357281 ccgccgttct ctatgacaat atattgggga gatacataat caatcgtccc tttaacaaat 2357341 tcaatcacgc aaattcacct ctttgactgt tcttcattgt accataaaaa cagccaaagt 2357401 cttatagaaa agttaacata tgttcgcttc tctctcattc tttcacgaaa aaaaagacat 2357461 gaatacatgt cttcaatcag cggacgctac ccgctgtatg tcttcatatg ttcgatgaca 2357521 tcctcaaact ccgcttttgt ccgaaatgga atgcctttca gcagattttt ttgcatatgg 2357581 ctttccagcc tttctaaatc aatttgaaaa aaagactgaa ttggttcgga agctggctca 2357641 ggccgcccat gaaaagtgga aatcactcca ttatccgata caccgatata cccgttgacc 2357701 ttgctgagcg gagaaatatc gtccatttgc ttccggaaga gcacatatcc ctttttttgt 2357761 tccactagcg tccatccggc ataagctgcc caaaaatcat ccatagaaaa cactttttca 2357821 tgcttatgct caatgctgac atcgccgtcc aaatacacct tttcaagctg cacatgcacc 2357881 tgcagcggct catagtgctc cacttccgcg ccaagtgcgc gggaaggagc tcctattaaa 2357941 aatactgccg ctgagcaaag aatgcccagc aaaagatacg ccgtgctgaa tcgtttcacc 2358001 ctctacacct ctttgcacac gtttatgatt agtttgacca aagaggctac tgcttaaccg 2358061 ttttatcaaa atttgtctgc acattttccc tgacaaaccg ttcctccgta tacacatctg 2358121 tgctttgctc agaaattgtc aagaatcgcg tcagaaaggc actgaaaaaa tacaatgccg 2358181 caaagatcca aatcacgcca cctgcaccga gcggcccaat gaaaagactc acgatgcccg 2358241 gcgcgataaa cgcacataaa ccagatccca aattcaacac tgacatggca gcacctttat 2358301 tatcaggtgc aagcgtcggc aaaagcgcgc ttaatgggac gtaccctgct aaagccgcgc 2358361 cgtagcagca ggcgataatc atgagcaccc aatactgatg cccgatcagc tgaggcgtgt 2358421 aatacagcgc cagcgtaaaa ataccgcatc cgacaccgcc aaaccacatg accgtattgc 2358481 gccagcctag tttatctccg actgcaccga aaatgatatt aaacacaata ttcacaaaaa 2358541 acagcgtccc ccatatttgc agccattccg aaaccgaata cccgtatcgt gctaaataag 2358601 taggaagaaa gatggcaaat ccaaattgtc ctatcgcatt aatcgtcttg accactccgc 2358661 cgatgcctac cttagggttt tcaaacataa tcgtaaatgc cttcgacagt tctttccatt 2358721 tcggctgatc ttgtttttgt atcggagtaa atttatcttt gttaaaaaat aaggcaagaa 2358781 ttccgcctgc cgccacaaac agtaaagcgc tccaaagcgt attgatttct ccaaaggccg 2358841 gaactgcata gctggaatag aacggaccga gcacgttaag gccgcacgta aacataaacc 2358901 aaaaccagcc gacggctttt ccaagaatat tttgagaggt gctgtatgac acccatacga 2358961 gaaaagagta tgcaaacagc ggatatccca agcctctaag agcatagctg cccaagagag 2359021 ccggataata catatgagga atcgcccagc cgataaaagc ggccgaaccg aggataaatg 2359081 caagcaatcc gacagtcatc gtttttctcg gcccccaagt ttggacaaac gttcctgaaa 2359141 gccaagctga gatggtgaca gcaatgccgt acatggtaaa taacgatgcg gattgctgca 2359201 tactgagacc atgatcaacg agaaaaggag acagccagcc ttgttcgagg ccgtctccaa 2359261 ccataaagat gacaacgcca atataacccc aaaccatgtg agaaggaatt ccgattttgt 2359321 tcaaaacatt tcctttagca tgtactgtat tcattttctc caccgcctac ttaaagtatc 2359381 aatggagtat atacccaagc ttgctgaatt gtaatcctgt tagattaaaa agcgattttt 2359441 tcagtgtgct caatgctaac aggcatgcca aaagcaagcg attgctgtgc tgctctggcg 2359501 atcctcccgg cctgtaaacc gtcattgccg gtgcagggag tctcctggtt tgtgccgatc 2359561 gcttctgcaa aacggagaat ctcctcctca tatgaatcct tatagcgttc aaggaaaaag 2359621 aaatgcggtt tatccttcat cacaaaatca gctgttgaca cctcaaccgt tgtcggcctg 2359681 ctattgtcag ccgctgcaga gcctttcgtc ccgaaaacct caacccgctg gtcatatccg 2359741 tacacagctt ggcggctgtt atcaatcaca gccatggcac cgttttcaaa agtcagtgta 2359801 ataacagctg tatcaatatc acccagctcc gcaaaagaag gattcaccaa agccgcccct 2359861 ttggcataca cttccgtcac ttcgcttccc ataatatatc tggccatatc aaaatcatgg 2359921 atcgacatat ccataaacaa tccgcctgac gtacggacat aatctatatt cgggggttct 2359981 gggtcccggg acgtgatttt taataaatga ggtgtaccga tttcaccatt ttcaacaatc 2360041 gttttgattt tcttaaaatg aggatcaaag cggcggttaa atccgacttg aagtgttacc 2360101 ccgtgtttcc ggacagccgc aagcgcttca ctcgtttcgt ccagagagaa actaacgggc 2360161 ttctcacaaa atatatgctt tttcgcctcg gctgcttctt tgatcatctg tgcatgtacg 2360221 gctgtaggag agcaaataaa aatagcatca atatcaggat catgtaataa atcacgataa 2360281 tcagaggtta tgtattcaat ctgatgactg tcggcccagc tttttatacg gctcgcctga 2360341 atgtcagaga ttgcttttat tttcatgtga ggaatccggc ttatattttg aacatgaagt 2360401 ttgccgatgc ggcctgcacc gataatccct gtcacaatct gttttgtcat ggcttcttcc 2360461 cccttgatca ttcacgaaag cgctttattt aaaattaata ctatcccatt tgtaagcgct 2360521 tttcaagaat ggaaattaaa cgttctatgt ctcttttatc acaattcatg cttataagta 2360581 gccttcttct tcaagaccag atacactaga attaggctct ttttcctgaa cagtttatga 2360641 ttttcctata aacagctgca taaaatagag caaagaaggt gaatgaaatg ctgacaaaag 2360701 cagaggcact ggcccatacc gtcatatacc gcaagaacag cagatttgat aaagtcaaag 2360761 agaaatccga ggaattaaca ctaatcggca agggaagaag cgcctatgtg tttgccttaa 2360821 cagaaggcgg tcgaaaaatg gcgctgaaag tattttttcc ggaatatcaa gcgacagcag 2360881 tcaaagaagc agcgatctat gaaaaattag ccgggtccgc attctatcct gacatttacg 2360941 aaactggcga ttcatttatt ctcatggaat atattaaagg tgaaaccttt tataactgtc 2361001 tgaagaaagg cattgcaatc agtgatgaca tgattcagca ggttgaagaa gcgctttctg 2361061 acgcccgggc agccggactg aacccgtcag atattcattt gcggaatctg atattgacag 2361121 aaaccggggc ggtgcgggtg attgatgttg cgagatttga gcagacaaaa acatgcacgc 2361181 agtgggacga cttaaaatcc gcatatcatg cactctacaa aaaaccgata ttccccaaaa 2361241 agattccggg tttttggctg gagatcatcg catttttata taagaaagat tggtttcaaa 2361301 agcatttcgc acagcggaaa agaaaatatt cttaaatcaa aaaggcagcc gcacaagcgg 2361361 ctgcctttat catgtatttt ttactttctg acggcagaaa tcagtttcat ttgttcaggc 2361421 gacagcttaa ttcgatagcc tctcacagtt aagtagaccg cttctgggtc cttctcgccg 2361481 gaatgacaat acgttttttc catttctgtc tcccctcacc ctttattggc tttatttcat 2361541 cttatcattg ctttattgag gtaattttaa agaaatgtaa agattatatg aatccgatat 2361601 atagtaaaat gagagaaaaa aagggagaga gtcacattaa gaccgaaaac accttgagct 2361661 tagatgcagc cagaggtgaa cttgtaaatg aaaaaacact tgtcaagaga acaatctact 2361721 ggaattaccc ggacagccgc ccagcagtga cgtggatcaa tcacaataca gtgaaaatcg 2361781 gcaatcagac tttacatctt gatactgatg aaacgtatga ttggcgaaaa gatgatcatt 2361841 ggatccgtga agaaccgccg caggcgtcag tgaggtgatg aaacatgaat aagatgaacg 2361901 gaacaaatga tgaaaagcat ttcaatcatt ttgtgattgc tttatccttt atatacggtt 2361961 tgactgaact aggctatttg ttgctgaagg attttataac aattgccata agtttgcctc 2362021 tgtagaaaaa cgcagcgtag tcgatacgcc gcgttttttc tttttccctt cctcttctta 2362081 ttgataatta caggtcatat aatgtgacaa atcgattgta gaaatagttc gattagacca 2362141 aaatcctttt tatacatgta ttcgaatttg aagtgagggg gaagcttgat ggcagatttt 2362201 gttgctagtt tgaatgcggt cttatggagt acgcccgtca tttatatttt attgggaatt 2362261 ggattcgcct tttcaattat gacccgtttt ttacaagtcc gacatttaaa agaaatgatt 2362321 gttcagatgt tcaaaggcaa gagctctgaa gccggcgttt catctttcca agcgttatcg 2362381 attgcgctgt ccggccgtgt gggcacagga aacatcgcgg gagtggcgac agcaattgca 2362441 ttcggcggac ccggtgcagt gttctggatg tgggcgattg cctttatcgg ggcggcgagt 2362501 gcctttgtag aatcaacgct tgctcaaatt tacaaagtga aacaagacgg tcaatatcgg 2362561 ggcggccctg cttattatat agaaaaaggc ttaggcatta agtggtttgc cgtcttattt 2362621 gccgctgctg cccttattgc aatggccttt ctaatgccgg gcgtacagtc caactccatt 2362681 gcggctggga tccaaaatgc attcggcatc tctcctttcg tcacagggtg cggtctggtt 2362741 ttattattag ggttcattat ttttggcggc gtcaaacgaa ttgccaatgc ggcgcaaatg 2362801 attgttccat ttatggccat tggatatatc ctgctgtctt tgattattat tgtcatgaat 2362861 gtgtctgaat tgcctgctgt gatctcatta atattcaaaa gcgccttcgc attggattcc 2362921 gcttttggcg gcttgatcgg tatggcgatt tcctggggcg ttaaacgtgg catttactca 2362981 aacgaagccg gccagggaac aggcccgcat ccggcagctg ctgcagaggt ttctcatccg 2363041 gtcaagcagg gactggttca ggcattttct gtttatattg acaccttgtt tgtatgttcc 2363101 gctacagctt tcatgatctt gtttaccggc atgtacaata cccaggctgc agatggttcc 2363161 tttatcgttc accagcttaa aggcgtagaa gcaggacctg gtttcacaca agcggcaatt 2363221 gacagtgttc ttcccggatt cggtgcaggc tttgttgcca tcgctttatt cttcttcgct 2363281 tttacaacaa ttatggcgta ttactacatc gcagaaacaa atatcgccta tttagcacga 2363341 ggcagagaaa gcaaatgggc gatgcttggc ttaaaactga ttattttagc cgccacgttc 2363401 tatggtactg tgaaaacagc ttcacttgct tgggcattag gggatgcagg gcttggcatt 2363461 atggtatggc tgaacgtcat tgccattgtg ctgcttgcca agccggcgct ccttgcttta 2363521 aaggattatg agcgccaaaa gaagcagggc ttagacccga tctttgatcc aaaagcgctg 2363581 ggtatcaaaa acgctgattt ctgggagaaa gaatacactc atgaaagtga acgtgtctcc 2363641 tgaacatact aaaaccggcc cgatatgacc tcgtgccggt tttttatgaa cgatagtttg 2363701 tatacacttc ttgaacatca tcgtcatctt caaggacgtc tattaatgtt tccagcttct 2363761 caacagcctg atcatcggct tctgcatagg tattgggaag catggtcacc tccgccgaag 2363821 aaattagata tttcgattcg agggctgttt tcacctcttc aaaatgctca ggctctgtga 2363881 aaacctcata taggtcttct tcaattcgca gctcttctcc tcctgcttca agcacatcaa 2363941 gcatgagctc atcttcttct atttgccgtt cagtacggtc tatcgtaatg aacccctttc 2364001 gttcaaataa aaaggctaca catccgcttt ctcccagact tccgccattt ttattaaagg 2364061 ctgtccgcac atttgacgcc gttcggtttt tattatctgt tacgcattca accatgacgg 2364121 caatccctga agggccgtag ccttcatagg tgatttcttc atagctgctt ccgtcttggc 2364181 ctcccgcagc ttttttaatg gcccgatcta tattttcatt cggcatattg gcgccttttg 2364241 ctttttcgat gacaagacgc aatgctgaat ttgcttctgg atccgctccg ccttctttcg 2364301 ctgccacata gatttctttt gccagcttca taaatatttt cccgcgcttt gcatcctgtg 2364361 cattttttct tttttgaatg tttttccact tggaatggcc tgccatgttt tcaccttctt 2364421 ttacattttc tatgtacact ttaatgggaa atgttcgctg atgcaaagaa aaaggctgcc 2364481 gaatatcact tccggcagcc cttccttcct agcggttgtt cattttatga agttttctga 2364541 acagcccttt atctgttgat acttggacgt cacggccatt tgcatagttg cgcgctgctt 2364601 ttacaacatt atctctgtca gactttgtga actctctgtg gcttttgact gcgataacta 2364661 ctcggtcatc cgataccata acttgtgtgt cattgacgtt tttcacttgt ttcacacggt 2364721 tggcaatttt tgcagccagt cttctgtttt cttggttgtc atacccgttg ttcgctgcat 2364781 tccgattcat gtttcggtta ttcgtgttgt tatatgttcc gtcagttgcc aaaggaacac 2364841 gatcgtcagc agtaacacgg tcacggttat ttacattcgt ggtgtttcgg ttaccgtcgt 2364901 tctgatcctc cattaattca gaaacaggac catcgtggtc gattccgtct ccctgtctat 2364961 cggcgtcatt ttcatttgta taatatccga ttggacgggt attgccgtta ttgcgcgtat 2365021 cattcatagc attatcgttt gctccgcatg ctgttaagcc ggctgtcatt agaatcaggc 2365081 tagcgatcgt cattttttta cccaatggaa aaaccccccg tggacgaatt gagcatgttt 2365141 gctcgctttt atcatgtgcg tatggggggc atgttaagcg tgtcagttct ctccatttgg 2365201 cagtgatctg cttgaaaaca aaaaaaggaa cgatttacat cgttccgaac gatcactcat 2365261 tttcttcttc cggacggcca aacatttggt ttacagaagg ctggttcgtc attggcatag 2365321 aaactcctgc cgaatatggg tttggatttg ggttagctgt gccatatggc atattagggc 2365381 ttccataagc tcccattccc gaatggccag gtgcagagaa atatggctga tgatcaccgt 2365441 cacagccgca gtcgtcatga tctttgtatg gcatgtaacc atgagccgca gcaggctggt 2365501 atgctcccat tacttgggga gtgccgtaat aagggccata cggcatatgt ccatacggag 2365561 atccataagc cggagatgcg tattgcggcg caccgtatga accgtaatgt ccgtgatggc 2365621 tgttttcatg atgctggttt tcataacccg ggtcatactg aggcgataca aagcctggct 2365681 ggtatccatg catcggatgc attggataag cttgtgccgg atagtacgga tagcataatc 2365741 ctgatcctgg aagaattggc gaaacaggca ccggacacgg tacgaaatga gccggataat 2365801 gataataagg ctgaacagcc ggcatcggca tattcggaac tgtgtgatga acgttttcct 2365861 cttctatacc gcctacctct ggcgcctttg gcatattagg catattcgga taatttgcat 2365921 tttccatatt actcatagcc tcctgttgtg gaaattggtc ttgcatatga tacatatgat 2365981 ccatatttcc gtcatgatgt tttttcggct cctccggttt aggaggcgac caaggctgga 2366041 aaagctgttt catatcataa taatcgttca catcagcttc agggtacaca ttttcctgca 2366101 aattaggcat cggcgggaca tacggcatgg acttcttttc tttcggcttt gtgtcttcta 2366161 catcgacaac ggatttaggc ttctctttcg catatggatg ttcttgcttc acactcccgg 2366221 ccgcaggact tttgcccgct tttggctctt ttctgaccgg gactccttct gacggcactt 2366281 ttattttcat tccaggcatg attaagtctg gattgctaag ctgtgtattg agttttttca 2366341 cttcctcaac atcgactccg tacttttcag ctattttcca gagcgaatcg cctttttgaa 2366401 cgatatggat tttcaacgtt ttcccctcct atgcaaaacg tgaacagttc agctgtgatt 2366461 acaatatgtt tcttcacaac atatgcctga acaaaagaag ttatgagtaa aggaagggaa 2366521 aatatttctg atctacgtga tcgaaagcat tcgattcagg gcaaggagtg catcttcctg 2366581 aatggctttt ggcaccttga tgacgcctga aggttctcct ttttcaattt gttccagcga 2366641 ccacaacaaa tgcggcaaat caattcggtt cattgtcagg caagggcaca tgtcagggtt 2366701 gagtgattcg atttgtttat ctggatgctc gtgaatgatc cgctgaacaa gattcatttc 2366761 tgtcccgatt gcccacttgc ttcccgccgg agcctggttg attgtgtcga taatatattt 2366821 cgttgatccg ttatcatcgc ttagtgtcac gacttcgtgt gaacattccg ggtgcacaat 2366881 gatctgaatg tcggggtctc gctctctcat atcatggata tttttagtgg tgaatttctc 2366941 gtgaacagag caatgccctt tccacaaaat cactttcaca ttcgtatgcc cggattcagc 2367001 tactaattca tctttcatcg gatcccacac agccatatct tcaagcgcaa tgcccagatc 2367061 ataagccgta tttctcccta aatgctgatc aggcaaaaat aaaattcttt ttttctgtgt 2367121 aaacgcccat tcaagcactt ttttcgcatt cgaagaagtt acagttgctc cgccatgctt 2367181 tccgacgaat gccttgatct ccgcagtgga gttcacataa gttaaaggta tgatcgtatc 2367241 tccaaatata tgctgaagct tcttccatgc cctattggtc tgctgcatgt cagccatgtc 2367301 agccatagaa catccagctc tcatatctgg caggacgacc gtttgctgct cgcttgtcag 2367361 catatcggcg gtttctgcca taaagtgaac gccgcaaaat acgatataat ccgcttcttt 2367421 gtttttttcc gctacttggg ccaattgcag ggagtcgcct gtttggtcag caaattgtat 2367481 cacttcatcc ttttgataat gatggcctgg tataaagagc ctgctgccga actttttctt 2367541 aatggcggca acgcgcgttt ccatatcctt tctcgatagt tctttataac tttcgggcat 2367601 catatcattc gattgtttga tcacatcaag aattgacata acagcattcc tccacagatt 2367661 catttgataa cgtaacatcc atgctgatat ctaaactttt gacggaatga gtcagaaatc 2367721 ctaatgaaat ataattcaca cccgtccctt taaaagcagg caaagattct aacgtaatcc 2367781 cgccagaggc ttcagttttt atattagccg gtgtgagctt tgcaaaatga cggaccgtat 2367841 caggcggaca gttgtcaaac ataataacat ccgctccagc tgcaattgct tcccgcagct 2367901 gttcctccgt ttcaatttcc acctcgatat ttaccatgtg ccctgcggcc tgacgggctt 2367961 ttttgcacgc ctctaaaata gagccgcatg ctgcgatatg attatcttta atcatgatgc 2368021 cgtcatacaa accgaatcga tgattatacc cgccgccggc tctgacagca tatttctcca 2368081 gcattctgag ccccggtgtt gtttttctcg tgtcacaaat tttaatctgt tcatcatcca 2368141 gacaccgaac agcctctctt gtcattgtcg caattcctga cagcctctga ataagattta 2368201 atacgacccg ctctcctgaa aggagcgcag ctgcgggacc gtgtaactcg gcaatcactt 2368261 cacctttatg caacatgtcc ccatcttttt tgtgtaaaat gctttgaaca ttttcgtcca 2368321 ataacgaaaa gccttctttt atgatcgctg ctcctgcaaa aataccctct gactttgcaa 2368381 caatctccgc ttcacagctc tgttctccaa aaatagactg cgatgtaaga tcccctgtcc 2368441 caatatcctc aagaaaaaag tgattcagta attttttcag ctgtaaatga ttcattgttc 2368501 caaatcccct cgttttttct gatcttcgtt cctttttttg tatggacaat ttgtcttcct 2368561 tgccagctca cctcagcatg aggaaaatcg gtgcggaagt gagcccctct gctttcctcc 2368621 cgcaaaagcg cagaaaacgt catcagcttt gcagtttgcc atagatgaga aagttccatc 2368681 tgccgaattg tgatatcctt cacatttact tcctgaaaag gcagcgtatg aagccagatg 2368741 ctaagctcaa tcaaactgct ttgttcccgc agaatagaca tgtggcttgt cattttgctt 2368801 tgcagttcat gcccctctat atccggcacc tcgtagaaga cactggtttc tagccctgat 2368861 tgatattgcc tgttataaac cggtttttgg ataatatgct ctgctgccct ttttccaaat 2368921 accagcgctt ccaataaaga attgcttgca agccggtttg ctccatgtaa accggagcat 2368981 gctgtctcgc caatcgcata aagccccggc actgtcgttt ctccccagcg attaactgaa 2369041 acacctccca ttaagaaatg cattcccgga gcaacaggaa tttttccgct gtggatatca 2369101 atccctgctt tttcacaaat agcggtgatg gtagggaaac gcgtttcaaa atcagaaatc 2369161 gcactgaagt ctatataaac gcgatttcct tttgccattt cttcgtgaat aacccgtgag 2369221 acaatatctc ttggagccag gtcacctaaa ggatgccgtt cagccataat cctgcggccg 2369281 ttttcgtcta ctaaacatcc gccttcccct ctgacagctt ctgaaacaag cccgtaggaa 2369341 acaccatttt tcacaagcag tgtcgggtga aactgagtaa actccaaatc cgttaattcc 2369401 gccccggccc ggtaagccag agaaagaccg tcacctgtga cagtgagatc attcgtatgg 2369461 tgaagaaaca ggtttccaca gccgccggca gccagcacaa cttcgtctgc gtgccttacc 2369521 ttgagccgcc ctttgctgtc ttttgtcatg acgccgatac atcgtccgtc ctctataagc 2369581 aaatctgctg ccgtttcatt ctcgattaac ttgattttgc tgttgatccg tttgagcaaa 2369641 taatcgataa gcagcctgcc tgttgcgtct ccgcctgcat gaaatatgcg gttgtatgag 2369701 tgggcccctt ctcttccaag acaaacaccg cctcgttcat tgcggtcgaa tggaaatcca 2369761 cgctccaata ggctttgaac catcattttt ccatcatgta atacgtctgc tacaatagct 2369821 agattattat ggccgcaccc tgcgtataac gtatcctcca gatgggcttc aatcgagtca 2369881 tcttttgcat aggccgcagc aatcccgcct tgtgcataga cagaattgct gtttttgacg 2369941 cttttttttg tgataacagt cacttcgtat gagggcggga aagctgcagc taaggaaagt 2370001 gccgccgccc ctgaaccgat gactgcaatc gtctttttag acatatgcca tcctcctgtt 2370061 gtttacacct gtcttgacac ctatatttac acaaggataa aataaactca agagtttttt 2370121 atggagaacg gatggaggaa gaccggatga tttatttaga ttatgcagcg acaacgccta 2370181 tttgtgagga agcccttact gtatatcaga agcttagtat ggatatgtac ggaaatgcca 2370241 gcagcctgca tgatgcagga ggaaaagcaa agcacatact ggagtactgc cgtgaaaaaa 2370301 tcgccaacat cattggcgga gaagcaagcg gcatctattt tacaagcggc ggcactgaat 2370361 ccaattttct ggccattcaa tcattgttaa acggcctgcc aaaaacgaaa agacatttta 2370421 ttacgactgc catggagcat cagtccattc ataattgcgc tgcttttttg gaacagcagg 2370481 gatatgatgt aacagtcatt gaaccgaatg aatacgggct tattaccgag gaaatattac 2370541 taacccatat ccggccggaa acaggccttg tatctattca gcatgcaaat tctgaaaccg 2370601 ggatcattca gcccattcaa cacctgtctt catacctgca caataagggg attcttcttc 2370661 attgcgacgc tgttcaaacg tttggaaaga tcccgatcaa tacaaaaaat ctgggagtag 2370721 atgcactctc aatgtccagc cataaaatcc acggtcctaa aggagtaggg gcggtctata 2370781 tccggccgga tgtcccttgg aaacccgttt atcctctgac tactcacgaa tacggattca 2370841 gagccggcac cgtaaatgtt cccgggatcg gtgccttcac tgccgctgca gaattgatcg 2370901 taagcgaaat ggaaaaacag atatcccgca atgaggcatt aagaacatac tttctagacc 2370961 aaatccgtat tcggtctctc cctgtaaccc ttgcagcaga cacttcgaaa gcagaatgtc 2371021 ttccgcatat tatagggtgt ttttttcact catttgaagg acaatatgtt atgttagaat 2371081 gtaatcggag taatatttgc atttcaaccg gcagcgcttg ttctgcaggt taccacggtc 2371141 cgtctgaaac aatgaaagca ttaagaaaaa ccgaacaaga agctctgcaa tttatccgca 2371201 tctcttttgg caggcataca acagctgaac agctggaaca gttattacat acgtttacag 2371261 tgctttggga acaaaagaaa ggagaatttg atattgaccg aagaattaaa gctaatgggc 2371321 gccaacaggc gtgaccagct tcttctgtgg ctgaaggaat ctaaatcacc gctgacagga 2371381 ggagaactcg caaaaaaagc gaacgtctca agacaggtta ttgtacagga tatatcgctc 2371441 ttgaaagcga aaaatgtacc gattatcgcc acaagccaag gatatgtata catggatgca 2371501 gccgctcagc agcaccagca ggcagaaaga atcatagcat gtctgcacgg tcctgaacgg 2371561 acagaagagg aactgcagct catcgtcgac gaaggcgtta cagtaaaaga cgtaaaaatc 2371621 gagcatcccg tatacggaga tttaactgca gccatccaag taggcacccg gaaagaagtt 2371681 agccatttca tcaaaaaaat caattctacg aatgctgcct acttatcaca gctgaccgac 2371741 ggcgtgcacc tgcatacact gacagcacct gatgaacatc gcatcgatca agcctgccaa 2371801 gccctcgaag aagccggcat tttaattaaa gactaaaaaa agccctctag tgggcttttt 2371861 ttataattgg taagactggt atgcacccag aagcctcact ttgcagccga gtgcttcaag 2371921 ctcctgcatg gcccctggaa tcaatacatc atcaaacgct ttctcaatat caataataaa 2371981 gaaataatgg cctaatccgg ttttagtcgg acgtgactca atttttgaca ggtttaaatt 2372041 tctccaagaa aatgcagaca gcactctatg cagcgccccg gactgatcat cctgcggcag 2372101 catgaccatt aaggtcgttt tgggcctaga gctcaatttt gaattcactt caaaagatat 2372161 gttttcatcg ggagacagga taacaaatct tgtatgattg tccctataat cctgtatatc 2372221 ccgtttcacg atttttaatt cgtatgtaga agctgccata tcattggcaa tgaccccgat 2372281 attcagctcg ggatggtcac tgacaaactt tgctgccgcc ccggtagaat tggcgtattc 2372341 atatggaacg gaaggaaaat gtcgatgaag aaatttatgg cattgcgcaa tcgcgtgtga 2372401 atgtgagtaa attttgtcga gctctttcca tgcattctct cttgagggat ggacgagcaa 2372461 gtgctggtga atcggcaacg tcatttcacc cacgattggc aaaggctgtt catgtattaa 2372521 atagtctatt gttagattaa cagatccttc taaagcattt tccaaaggaa caaaagcaaa 2372581 atcaacttcg cctgcaacgg ctgcatctat acactccgga atggtgcggt aagcaacatg 2372641 ttcggcgccg ttttgaaaac aagaactgac tgctagatgt gtaaatgtag ctgctggacc 2372701 taaataaccg actttcatga cgattttctc tcccttatgc acctgaacct aatatttcaa 2372761 ccttttctac aaaatcaaac ttcctgagct tattcattaa tgtatgaatg tcttcttcca 2372821 ttgccgacgt actgatagac agtgtcacat ttgctctgcc ttgaagcgga atggtctggt 2372881 gaatggaaag aacgttgctt ccagaatcag ctaccgcctg aagaagctga gataacgcac 2372941 ctgacctatc ctccaaatga aagaaaagtg tgataatttg ttcttttacc atggtgtaga 2373001 atggaaaaac agcatccctg tatttataaa acgcacttct acttaaatcg accttttgaa 2373061 cggcatctgc tactgaatct gctttttttc gatcaagcag ctttttgact tctaatgttt 2373121 ttctcattgc atcgggcaat acatcttcac ggacaagata aaatgtctcc tctttcattt 2373181 gcatcccccc tttaaaatag agagcctggc accaggctct cttttcagcc aacattgatt 2373241 aatcaataaa ttcaaattca aattccagaa gcctgattat atctccatcc ttggctccgc 2373301 gttctctgag tgcttcatca acacccattc cgcgcatctg tcttgcaaac cgtttaaccg 2373361 attcatcacg tgagaaatca gtcatcttga ataaccgctc aaggctgtct cctgaaagca 2373421 caaatacacc gtctggatcg cgtgtaatgt taaatggcac ttcttcattt tccatcgtgt 2373481 acatgacacg gttttgtgta agctcttcct cgtcatacag cgggaattcc ggtgtgttct 2373541 caagctgatt ggcaacctca aacagaagct cacgcagacc ttctcttgtc accgcactga 2373601 tcgggaatac cggataatca tccgtcagct tttctttaaa ggcttcgaga ttttccgcag 2373661 cctccggcat gtccatttta tttgcaacga taatttgcgg acgctcagtg agacgcagat 2373721 tgtactcgct cagctcctgg ttaatcgtaa gataatcatc atatggatca cggccttcta 2373781 agcctgacat gtcaatgaca tgaacaataa ccctcgtccg ttcaatatgg cgcaaaaact 2373841 ggtggcccag tccgacgcct tggtgtgcgc cttcaatcag ccctggcaaa tcagccatga 2373901 caaagctgcg tccgtcatcc gtttcaacca tgccgagatt cgggacaagc gttgtaaagt 2373961 gatagtccgc aattttcggt tttgcagatg agacaacaga cagcaaagta gattttccca 2374021 cactcgggaa cccgacaagt ccgacatctg caagcacttt taattcaaga acaatgtagc 2374081 gttcttttcc cggctcgccg ttttctgaaa gctgaggcgc gggattagcc ggtgtagcaa 2374141 agcggctatt tcctcttccg cctcttccgc ctcttgcaat gacagcccgc tgtccgtgct 2374201 ctgttaaatc agcgatgacc tgttttgtat catcgtctgt cacaacggtg cccggcggaa 2374261 ctttaatgac catatcatca gcatttcgcc cgtgctggtt tttggacatg ccatgctcgc 2374321 cgcgaatcgc tttaaagtgt tttttgtatc taaaatccat cagggtgcgg agaccttcat 2374381 ctacttcaaa aacgacgtct cctccctttc ctccgtcacc gccggcaggg ccgcctttcg 2374441 gcacatattt ttcacggcga aacgcaacca taccgttgcc gccgtcgccg ccttttacat 2374501 atactttgac ctgatctaca aacataatgt cctccgttct aaaccgttaa aaactccgct 2374561 agtccaaccc aatttcaatc agacattcgt gactcgtgat ttcaaaacgc atgatatcaa 2374621 cgtcctcata tccattctgc cgaatatcat caaaagcaga tggatcggca aaggcgccgt 2374681 gaaaatcaag gtacagaatc agctgtctgt caggatgatc cgtttgaagc gaaaccgtta 2374741 aatgattttc actctctctg ctgactgctt gatcaaacag atgaaacagc tttctcatca 2374801 gtttcgccag cttttgatca taagccgaca aatccttaat ttctccgaga acttcatatt 2374861 caagcgtcat ataatgggtt ttccaattaa acgtaagaaa atcaaacgcc aaatgcggtg 2374921 ttttcaggtt tgagagcttt gattcgtgct ttgcgtctat aaccatttct tcaatcattt 2374981 caaagacacg gtcatacttc tgtaagctta agtttccttt aatcagctgc agcttattca 2375041 tccaatcatg ccgggaatgg ccaagcagat gaatcagttc gtttgttaat gccgtgtcgc 2375101 ttatattttc ttcttgattt tttgaaacat ccttcatttt cgcactccca atcatttaat 2375161 ttcttattta ggagtctgta taagtgtgta ttatgaatta taacagagaa ggctttgtta 2375221 gaaaaacaat tgtttttccc agaaatatca tgttcctttt ttctggcttt ggttgatttg 2375281 cagccaggca gaacatttta tgtattactg cttggggaac atatccagtg ggtttgagat 2375341 gtttattctc attcttggcg gggtctgctc gcacatactc tgcatttcat tctaggtgtt 2375401 tactccgcat attgcaaaaa aaactccagt catcatcgac cggagttttt tgaatcatta 2375461 ttgagctaca ggatatacgc tcactttttt gcggtcacgg ccgaaacgtt cgaatttaac 2375521 agttccgtcg attttcgcaa atagagtgtc atctccgccg cggcccacgt tttcacctgg 2375581 gtaaattttt gttccgcgtt gacggtaaag gatagaaccg cctgttacga attgaccgtc 2375641 agcacgttta gcacctaaac gtttagcctc agagtcacgt ccgttctttg tagaacctac 2375701 tcctttttta gaagcgaaaa actgaagatc taatctaagc atgtagctca cctcctatat 2375761 tatgtttgtg gtcacacgca agttgtcttt gtaatcccgt tcgattgtct ccagcgaaac 2375821 aatcatgcct tcaatcagca gctgagcttt ttggcgtgcc tctggatcaa gagattcagg 2375881 gaattcaaaa taaaaataac ccccgtcctc tcctatatca agaagcggct cgaagcccgc 2375941 gagcacaatg accgcgttaa cggccccaaa cacaacggct gtcactccgg cacaaacaag 2376001 atcttgtcca tgttcagcaa aattcgcatg gcccgtcatt tcaaaagaca atatgccttt 2376061 atcatgagac cttctgattg ttgcctgaat catgcttacg cgttgatttt ttcgatcgtc 2376121 actttagtgt aaggctgacg atgaccttgt tttttatgaa cgtttttctt tggtttgtat 2376181 ctgaaaacag tgattttttt cgcgcggcct tgtttttcaa ctttagccgt tactgttgcg 2376241 ccttcaactg tagggttgcc gactttcacg ttgtctccgc caacaaacaa aacgtcttca 2376301 aaagtaactg tttcacctgc ttcagcagca agtttttcga tgtaaacagt ttggccttct 2376361 tcaactttga tttgtttacc gcctgtttta atgattgcgt acattctctg cacctcctat 2376421 tagactaaga ctcgccagat accagggggc tgtaaaagct cttaacacct gtactgagcg 2376481 gttgtagcaa tggtgctaca tccataacat taaaaaatat accaaaatac aaggcgtttg 2376541 tcaatcagtt ttagtagggc agaagcagtt cctccatgga agaattcgtc cgcttatcgg 2376601 caaagtaagc gtgcagcact tcattctcgt caagctggct gagcttttgg cctgattttt 2376661 ctataataat cggatgctta cagccacgtt tgaactcggc catcacatga tagactttat 2376721 cctccgcctt tactgtcagc ggcagaagtt tctcaagctc cctgtttttt ccgtaatacc 2376781 tttcgaggag aaatctcaca tggatatagt gcctttgccg atattcctca aacaaggaaa 2376841 cagccagaaa gacaaacaaa acccatgcgc tgatttgcag aggaatcacg aataaaaccc 2376901 agcacccgag cagcaggcag aagcagagcg acgtttttag attaagccgg tgagcctttt 2376961 gaaaaggcag ctgtttggaa aacaacaaaa ataacagttt tcctccatcc agcggccaga 2377021 tcggcagtaa attgacaaat aagatagaaa gattataaaa ggtgaagagt tcaaaggtat 2377081 gctgatgaat cactgagact tctgcaagca tccaggcggc aaactgaagc cagatgtgct 2377141 gaagaggtcc ggcaataatg accgcaaact cttcctttaa cggccgattc ccgtgctctt 2377201 ccacttcgac cgttccgcca aacggcagca aaaaaacacg cttgattctc caagaaaaaa 2377261 acacagccag agcagcatgc cccagctcat gaatcaatac aatcaggagc agacataata 2377321 atgctttcat atggcctgtg agcaagccca gcgccgcaat aatccaaaga aaaggatgca 2377381 catggatctt taagataagg tcgagccatt tattcaaatg aaatcacctg aatcggatca 2377441 ataaatttat cgccgtcttt catggcaaaa taatagaccc ctttattatg atcatcaagc 2377501 ttaatcgaac cgagcttttt gcctttatcc acaaaatcat ataaagcaac atccacatct 2377561 ttgagctcgc catagatact ataggtgttg tcagcatgct gcaccttaac cgtcagtccc 2377621 gtttggctgt ctttgctgac ttcaaccaca tagccttctt ttacgctatc aatcttatca 2377681 ctgcttgttt cgactttaat tccttcccca ttgtcctgaa aatcctgctg tactttcccg 2377741 gatgcaggcg cgatcagatc tttgcctact tcaatctgct gttccttatt tttgtgttca 2377801 ggagccagga aagcaagcgg atttccgaat ttggtttcga accaatggct tgctgaagca 2377861 aattgaaatt cagtttcaaa ggttttggct acggcgggtt taatctgact gacgggtcca 2377921 atgtttgttt tataggctat agctgaaacg agaacaaggc aggccgacag aagacatttc 2377981 aggataattg aatctgtttt caccaatggg tgttttccgt tgaatgttgg catgttatct 2378041 tcgtagaccg gaagtgttcc atgcttttcc tgatccgtta ccatcaccca ggacgggggt 2378101 ttctgctttt cagaaactgt ctgagtagag aaacgttttg agccggaaag ctgctttctt 2378161 cttttctcta atcgttttct gatttcatct gctctgtgac tcattgccat catcctttgc 2378221 attcgttggg tttgtacatc atatgtcttg tccatggcaa atattcggtt tagtcaagaa 2378281 caaagcaggc aaaaacaaaa aaaacctgac acagcatatg ctttgtcaga ttcttctctt 2378341 tgattctatc acattaagat cttactccga aaaatgactt aatcttagcc atcattcctt 2378401 tgttttgctc ttcaagcacc tgtaaaggaa cagattcacc taagatgcgg cgggcaatat 2378461 tgcgatatgc aatggaagcg cggtttttag ggtccatcgc aatcggttcg ccatgattgg 2378521 aagctttaat gacttcatca tcatcagcca cgattccgag caaatcgatc gacagatgct 2378581 gtacgatttc gtcgatatcc atcgtgtcac cgtttttcat caggtgattt ctgattctgt 2378641 taacaacgag ccgcggcggt tcaatatttt cctcttgctc cagcagtcct ataatacggt 2378701 cagcatcacg aacagctgag atttcaggcg tagtgaccac aatcgcttta tcagctccgg 2378761 aaacggcatt tttgtaccct tgctcgattc cggcaggaca gtctatgatg acatagtcaa 2378821 attcctgttt gagctcttgg accatgtttt taatttgttc aggagcaaca gctgtcttat 2378881 cgctcgtttg agcagcgggc attaaataga gcagatcatc gaaacgtttg tcttttacga 2378941 gcgcctgatg cattttgcat ctgccctcta caacgtctac cagatcgtaa ataattctat 2379001 tttcaagacc cattacaaca tcaaggttgc gcagtcctat atcagtatct actaagcata 2379061 cgcgcttccc taaaatggct aaggcggtac cgaggttcgc agatgttgtt gtcttaccta 2379121 ctccgccttt tcccgaagtt attacgatag cctcacccaa ttcacattcc tccctcaagc 2379181 cttgttagat caggtcttaa atgagccaaa tgttgaaggc gttcaatgac catatttccg 2379241 tctgtatcta aataagcaca ttccatttcg ttcccttttt gaatgtggtc tggggagcga 2379301 tttaacacat gattgattct taattgtgtc ggaagcattt cagaggcggc gatgaccgct 2379361 tgattatttc cattgaatcc agcatgcgca attcctttca gtgagcccag aacaaaaatg 2379421 ttccctccgg ccctgactgt tccgccggga ttcacgtcac cgatcaggag caagtcgcct 2379481 tttacctgca gcacttggcc tgaacggaca atttttgaaa cagaaataat ttcggcttcc 2379541 tctcttatct gctgtgcttc ttttttagta atgacttcac tgtcaataga atgaacaaac 2379601 aaatctttct ttgacgcaat caattcggtt agctgttcct cttgctcctt atataaaaag 2379661 cgatttccca gcttaacatg aacgctgatt ttctggcctt ttccatcggt atattgttca 2379721 attgacagca tattctgaag accatcgaga agctcatcaa aagaacacgc atcatccaga 2379781 tgcaatgtta gtccattctt tgttcctttt attgttacat attgctgctt tttggtcttc 2379841 acaatattca cctcaacaac atactcattt cgtcaaaaaa agataaaatc ctttttactc 2379901 atctctcaat tctttcttta gactcataaa aaacaatcta aatggcagaa caagaataag 2379961 agctgctgca atatttaata aaattgtcgg tataaaccgg tcaagcacaa atccgttaaa 2380021 cgtcataatg tctttatgaa tcaaagactg aatgccgaat acgtaaaatt cgagcagaca 2380081 gacagccaga actgctatca atatcactac aaatgcgttt gtatgcaaca ctttaaacgc 2380141 ttttgaagcc aaatagcata gccctgcaaa accaaacatg taaacgccta atagacttgt 2380201 atagttcatg tcatatagaa agccaaaaat aaatccgtaa atcatcgcgt gtttttggtt 2380261 gataaaagcc gacatgaata tcaatacaag catcaaaaaa cgcggggcga gcacttggtc 2380321 atctgtaacg aaaggaaaat gcaccaaatc tgtaaaaatg ctttccgcag aaaaaacaag 2380381 catcataacg aaagggagaa ggaaacgttt cacgatcctt cctcctctgt atcgacagtc 2380441 ggcacgtcac ggttaacaac gatcacatta tttaaatctg taaggtcagc cgcaggtttt 2380501 acataagcaa ccttcgttaa tccataggaa tctgactcga tatcagtcac ttcaccgatt 2380561 gtcagccctt ctgggaaaac accgcctgtc cctgatgttt caataagatc gccttttttc 2380621 acgtcttgtt tatccttacg ctcaataatt gtcatcttaa gacgtttttt ctctttgtca 2380681 tatccttcga tcaagccgta gcctttgctg cctttttttc cggaaatttt tgtcgcgact 2380741 ctgttattgc ggtcagtatc gcttaaaagc tgaacagcag acgtaaaatt gttaagtccg 2380801 gagcttttga tcttgccgat taatgcgcct ttttcgtttg taacggccat atctttcgct 2380861 acgttttgct gagtcccctt gttaatggtg acctgtttcg cccaattatc agggcttctg 2380921 gcgatgaccg ttgctaaaat cggcttgtaa tctttaatcg atttgacatg gccaagctcg 2380981 tcacgcaagg atttgttttc ttcttcaagc tcttgaagct tggcttcata ttgtgtctgt 2381041 ccgtcaagtt tttctcttag acgctcgttt tctttgtatg tgttttttaa atcattgatg 2381101 ttctcaaata ttcctgcaaa aaattcggca ggcgtatgaa aaatattttg aaatactccc 2381161 gtcgtatcgc cgatcacttt ctcaggccag gtggtattgc ggccgccctt cagcgaaaat 2381221 ccaatcatag ccaccaatat gataatacac agaagtaata gcattaaccg cttattcggc 2381281 atcgtgttac acctcttcta ttgaactccc gattatctag ttttcccttt gaaaagatgg 2381341 atgtgctcca gtgctttccc tgttccgatc gctacacaat caagcggatc ttcggcgata 2381401 aggaccggca tttttgtttc ttcgctgatg actttgtcca aattgcgcaa aagcgctccg 2381461 ccgccggtta acactatacc tctgtccatg atatctgctg caagctcagg cggtgttttt 2381521 tcgagtgtgc tcttcactgc ttcgacaatt gtagatacag tgtcgcgtag agcgttagaa 2381581 atctcttttc ctgtaatttc aattgttttc ggcaaacctg tgagcaaatc gcggccgcgg 2381641 atttccatgt tgtcggattc ttcaggagct tctgcagatc cgatttccat tttaatcgct 2381701 tcagccgtac ggtcaccgat catcagattg tacgtttttc tgatgtagtt gataatcgcg 2381761 tcatccatct catcaccggc tacacggatt gactgagacg ttacgatgcc tccgagggaa 2381821 ataatcgcaa cttctgtcgt accgcccccg atatcaacaa ccatgcttcc agtcggttcc 2381881 caaactggca gattggctcc gattgctgcg gcaaaaggct cttcaatcgg atacgcgtca 2381941 cgcgctcccg cctgtcttgt cgcatcgata acagcgcgtt cttcaacagc tgtaatgcct 2382001 gatgggacac ataccattac atatggtttt ctggcaaaca tgcctttatt ttttatggcc 2382061 tgattgatgt aatatttcat catcgtcgcc gttgtttcat aatcagcgat aacgccgtct 2382121 ttcatcgggc gaagagccac cacgttgccc ggtgtccgtc caatcatatt tttcgcatca 2382181 tttccgacag cgacaatcga tttcgtatcc gtctgcaaag cgacaactga cggctctctc 2382241 acaacaattc cttttccttt tacaaaaaca agcgtattcg cagttccaag atctatacca 2382301 aggtctctag caccaattcc aaacatatgt atgtatcttc ctttcttaaa gcaaaaatac 2382361 cctaaaggga aaaactcata aactctatta tagcttaatt cgacgaaaaa aaaagtgtta 2382421 caaatatcct ttttccttta aactcacaaa ttttttatcc ccgatcacca aatggtcaag 2382481 cagctcgatg ccaatcaggt ttccgcattc aaacagccgt cttgtcactt caatatcttc 2382541 cctgctcggc gtcggatctc cagaaggatg attatgaaca cagataaagg aagcggcaga 2382601 tcgtttaaac gcttctttaa acacctctcg cgggtggaca atagatgaat tcaggcttcc 2382661 gataaatacg gtgcgtttat ggatgacttg attttttgta tttaagtata aacagacaaa 2382721 atgctcctgg gttaaaaagc gcatatcctc catgacaaga ttagcgccgt cttccgggga 2382781 gcgaataacg aaatgttctt cgttggctaa tttatgaatc cggcttccaa gctcaactgc 2382841 tgccagtatt tgaatcgctt ttaccatacc gattcccggg atgcttgaca gctcttcaac 2382901 cgatgcttcc ttgagcaggc gcagcccgtc aaatgagcgc agcagccggt ttgacaggtc 2382961 caaaacagat tcgtgtttag tccctgtccg caataatata gccaaaagtt catgattcgc 2383021 taagttctcg gctccgactt tcaggagccg ttcccttggc ttttctttca ttgggaaatc 2383081 tttgagtttt aatggcagat cgtgtatgac caagcactcc ttttctttcc cttcccgttt 2383141 atagaaccgt catgccctta tatcaaaatg gcgaagagct ctcattgttt ttgatatagg 2383201 aaggcccatg actgaataat aatctccgtc tattttcttt acaaaaagcg cgcctcttcc 2383261 ttggatgccg tatgcacctg ctttatccat cggctctttt gtttcaatat atgtccaaat 2383321 ctcttcttca ctgagggacc aaaacgcaac ttctgtctta tcataaaaag tctcgctgtg 2383381 attttcagct tgaatgctga ccgcggttat tactgagtga cttcggcctg aaagcctccg 2383441 cagcatagaa gcagcttctt cttgatcctg cggtttgcca agacattcgc cgtcaaggca 2383501 taccattgta tcagcaccga taacgattgc atgcgggtgg agatcagcta cagccttagc 2383561 tttttgtttt gccaaccatt ggacgttttc ttctggtgaa aagtttcgat ttaatttttc 2383621 ttctacttca ctgacaataa tggagtaggg cagctggaga agatcgagga gttctttcct 2383681 gcgcggagat tgtgatgcaa gtattagcgg ttttgtcatg ttcgtcatcc tttcagggtt 2383741 tgcttaagaa aaaaagatac tcgtttatcc taccaaatca cgaggcttgt cacaatttca 2383801 gaaaaataac tttttcatga caaaataaaa aaagcctgtc actaaaggac gaaggctcag 2383861 ggcactatct cttattttac gacggctaac agctcctgct gagccttcca cccggcttca 2383921 gcacttggat cctctaattc ctttaaagcc tgcaaaatcg cttttttctc tcctgtttct 2383981 gacgcttttg tttcaccaag cgacttttct attttctcta cactcgcttt tgtaatgtct 2384041 tcgtcgagaa tcgcctttgc tgcaagctcc gctgtttcct taaaagaatc tgtcatatct 2384101 gactctattg ataaggaaag ctccttgcct ccccaggctt caaaatcact gtcgattaaa 2384161 acctgtccta actgctgtga gacctccttt tcacttgcta agcctgcaat aacatacgta 2384221 tacccgtcat cctttgacag tgacacggcg gaatatcctt tttcggtcaa ttgttctgtt 2384281 aacgtttcgg cgcccttttc atttgaaaat tttccggctt gcacagcgta tgttttgtat 2384341 gtaccttcag tttgtgccgc ttgtttttct gcgcctgagg tttgtttatc agcagaagta 2384401 tcccctgctt ttgccgtttg gctgcctaaa gaatcctcta aagaggccgg tgctgacgct 2384461 tctttattcc ccgatatgtt taacgcgaat aaccctaatc cagtgccaat gacagccgcg 2384521 aaggcaatcg tcgcggccac tctttttacc ggtttggcag ccccggtctt tccttttgcg 2384581 taaagctttg tttttttctt ttgaaaagga ggaacaactt tagggtcctc tttaaacacc 2384641 ttgtcctcct cggaatccca attgaattca tcttcatcag ggtgttcctg ggatgccgca 2384701 acctcttgtt ctgcctgtct tttttcctcc caatttgaaa atgtcatgct tttattcgcc 2384761 tctgtctcag gcgtctcttg ttcgtaaacc gtctcttctt ttccattaat cgtcaccttg 2384821 agggcttttt ctgcggcttt actgtttttt ttattctttc tttttttcaa ttccgcttcc 2384881 tcccttcatt tgcttgaccg ttcttgtcgg cttttcatgc tacacacttt agcacaggca 2384941 aagaaaaaaa gaacaagact tttgtcgcct tgtccaaaaa acgttcgtca aatttttcag 2385001 cagtcagccc aatgccattt tgatataaaa agaaatgata gagtcaccgt ataaataggc 2385061 taaaatgctc cctgcggcta tagcgggggc gaagggaagc ggctgccttt tagcgagtct 2385121 accagtcaga acagctgccg ctccatataa tgcacctatc aaaactgaaa agaaaaaggc 2385181 agctgccagc attttcacac caagcacaaa gccaatcacc gcaaataatt taatatctcc 2385241 tccccctact cccccatggg tgattgcggc aattacagcc agaaacaaaa atccggctgc 2385301 cgcacctaac aggcctgcat accaggaatc aagcggagaa atcaatctcg cggccgccaa 2385361 aaagggaaga aagaaaatca atattcgatt tggaatcagc ataaaatgaa tatctgtcac 2385421 tgcaacaata atgagaagag agataaacac cacagcggga aacagttcca gcgatatgcc 2385481 aaagcgtatt cctgcggcgg caaataaaca cgctgtcaca agctctgctg cgggatacat 2385541 aaaagaaatc ctatgcccgc agcttttaca tttacctttt tgaaatagga atgacaggat 2385601 gggaattaat tctgcaggag ttaatgttcg ccggcaaaac gggcatgatg aacggggcgc 2385661 aataatagat agatgtaagg ggatacggca cccggccgta tagtaaaaag aaccaaggat 2385721 aagcccgaag ataaaaagaa tggatagcat agacaacaca cctttactca ttgagttctg 2385781 gtatggattg tagcaaaatg gacatcctga gctccaattg ggaatattca attttacaca 2385841 tgaaaaaaac ggcagaatct ttttttgatt ctgccggagc cggatgcttt tatttcaacc 2385901 tttttcgaat gtcagaaata aagtaaagag atccggtaat cagcacaatt tcatttgagc 2385961 cctttttact ttctatgaat ttgattacat cgtctggatc ttcactccag cttttattgc 2386021 tgatttcact tgcatcatag agatcttttg caagggaagc acgcgggaaa tcaaaagaag 2386081 caaaatgaat cgcatgagca atggtttcca gtcttttaat catgttctga tacggtttgt 2386141 cctttaacgc gctaaacacc acagaaatgc gtgaattggc gaaacgctgc ttcatcgttt 2386201 ccgccagctt ttcaacacct tcttcgttat gcgcaccgtc taaatatacc ggaggatgtt 2386261 cctgaacaag ctctaaccgt cccggccaag cagccttcac aagcccgctc cttaacgctt 2386321 cgtcactgat atgggcgata ttctccttat tgagccactc cgcagccaaa atggacaaag 2386381 cagcattttg tctttgatgg gtgccaatca gagatgtccg aatatcttca tagcatttct 2386441 cttccgtttt gaatgaaaac tgttctcctg caggcagagc ctcttcattg aaaataacac 2386501 atgcatcatg caatgactgg aacggcgcag catgccgttc ggcttcatgg cggatgacct 2386561 gtaaagcttc cggctgggta actgctgtaa cgattggaat accttcttta ataatgccgg 2386621 ccttttctcc tgcaatttct tcaatggtgt ttcccaaaat gttcatatga tcgtgtccga 2386681 tgcttgtaat cacagttaag agcggttcaa ccacattagt agaatcgaat ctaccgccca 2386741 gacctgtttc aaaaataaca aaatcgacct tatgaaactc tgcaaaatat aaaaatgcac 2386801 aagctgtcat aatttcaaat tctgtcggct gtccgtattc cgtttgatca agggcttcaa 2386861 cgtgcggttt catttgattg acgagtgctg tccattcctc atctgaaatc ggtatcccgt 2386921 ttacgctgat ccgttcatta aacgtaataa tataaggcga tgtaaatgtt ccaaccgtat 2386981 atccggcttc ctgcagcata gaacggataa aagcgacagt tgatccttta ccgtttgttc 2387041 ctgcgacgtg gaacgctcgg attttttttt caggatgtcc taaccgcgcc atcagctgtt 2387101 tcattcgacc aagtccgggc ttcaccccga atttcagcct cccgtgaatc cagctgcgcg 2387161 catcttgata tgcagtaaac aatgataatc ccctctttta taagacaagg cggtttctct 2387221 agaaaccgcc ccggcttttc attaaccctt cagctcagcc attcgttttt gaacagcgtc 2387281 acgcttcgcc acataatctt tttctttttc acgttcttca tcaattacgt gtgcaggcgc 2387341 ttttttcata aatccttcat ttccaagttt cttttggaca cgctcaactt cttttgtcag 2387401 tttatcaaat tctttttgca gacgggcaat ttcttcatca atattgatta agccttcaag 2387461 cggaagaata acctctgctc ctgagacaac ggccgtcatc gccttatcaa cagcctcaat 2387521 atcggtgccg attttaagca cgctcggatt cgtaaagcgt tcaacatatg aacggttcgc 2387581 ttcgaggcgg gacgctattt cgtctgtgct tgttttaatg tacagttcaa cctgcttgct 2387641 cattggcgta ttgacttcac tgcggatatt gcgcacagaa cggatcagct caacaagaag 2387701 cttcatgtca gctgccgctt cagtatcggt atgctccggc actactgcag gccattgact 2387761 tactgtaatc gattcccctt ggtgaggaag gtgctgccaa atttcctccg ttaagaatgg 2387821 cataaacgga tggagcagac gcatcgtttg atcaagtacg taagcaagga tggaacgggt 2387881 agttttctta gccgcttcgt cttctccata aagcggaagc ttcgccattt caatatacca 2387941 atcacagaaa tcatcccaaa taaagttata taaatggcgt cctacttcac caaattcata 2388001 tcggtcagca agctgggtca cgtgctcgat cgtttcattt aatcgcgtta aaatccactt 2388061 gtcagcgact gacttttcac ctgacagatc aagctcatcg tacgtcatgc catccatatt 2388121 cattaatgca aaacgggagg cgttccaaat tttattggca aaattccagg tcgattccac 2388181 tttttcatag ctgaagcgca gatcctggcc aggagagctt ccagtcgcaa ggaaataacg 2388241 cagagaatcg gctccgtact tgtcaatcac atccatcggg tcgacaccgt tgccaagaga 2388301 tttactcatt ttccggcctt gctcgtcacg gattaagccg tggattaaaa catctttgaa 2388361 cgggcgctcg cctgtaaatt caatgccttg gaaaatcatg cgtgataccc agaagaaaat 2388421 gatatcgtac cctgtcacga gaacatctgt cggatagtag cgtttaaagt cttcagccgt 2388481 tacatcaggc cagcccattg tggagaaagg ccatagcgca gaactgaacc atgtatccag 2388541 tacgtctgta tcctgttccc aattttcgct gtcttccggc gcttcaagtc cgacatatag 2388601 ctcgcctgtt tctttatgat accaggcagg aatacgatgg ccccaccaca attgacggga 2388661 gatacaccag tcgcggatat tttccatcca gtgtaaatac gttttttcga aacggtcagg 2388721 cacaaagttg accttttctt cttttttttg cagctcaatc gctgcatcag caagcggctg 2388781 catgcgcaca aaccattgtg tagaaagata aggctccaca acagccccgc ttcgttcact 2388841 atggccgaca gagtgcatat gatcctcgat cttgaagaga actcccgcct cctgtaaatc 2388901 tttcacgagc tttttgcggc attcaaaacg atccatacct tgatattgga gcgcattttc 2388961 attcatcgtg ccatcttcat tcatgacaag gatgcgttct aaattgtggc ggttgccaag 2389021 ctcgaagtcg ttcggatcat gagcaggcgt aattttcacg gcacctgaac caaattccat 2389081 atcaacatag tcatcaccga caatcggaat ttcacgattt acaatcggca ggatcaccgt 2389141 ttttccgata aggtgtttat agcgctcgtc ttcagggtga acggcaacag ctgtatcacc 2389201 gagcattgtt tcaggacgtg tcgtcgcaat ttcaattgag cctgaaccgt cagcaagcgg 2389261 atagctcata tgatagaatg cgccttgaac atccttgtaa atcacctcaa tgtcggatag 2389321 ggctgttttt gtcgctgggt cccagttaat aatatattcg cctctgtaga tcaggccttt 2389381 ttcataaagc ttaacgaata cttcccttac cgctttgctc aagccttcat ccagcgtaaa 2389441 acgttcacgg gaataatcta ggccaagacc taatttcgcc cactggctgc gaataaagtc 2389501 agcatattct tccttccact tccacgtttc ttcgaggaat ttttcacggc ctaaatcgta 2389561 gcgggatttg ccttcttcac gaagtttcgc ctccacttta gcctgtgtcg cgatgccggc 2389621 gtggtccatg ccaggaagcc acagcacatc atagccctgc atgcgtttca ttcttgttac 2389681 aatgtcttgc agcgttgtgt cccatgcgtg gccaaggtga agtctccctg ttacgtttgg 2389741 cggcgggatg acaacagagt atggctcttt tgtctggtca ctgcccgctt caaaaaattt 2389801 gccttttagc caaaaatcat atcggtcttt ttcaaccgct gccggatcat atttcgtcgg 2389861 cattgtttgt tcattcgttt ccatcataac cctccagcat gtttaaaaat ggctgagaac 2389921 gaaaaaagag ctcttcatcc ctgtaaaagg acgaaaagct ctttcgcggt accacctttt 2389981 ttcatgaact caatcagttc atgcacttat aacggataac gggtgtttcc cgaatttctc 2390041 tactcttctt tcaagaaatt atgctcccgg gcgaccttcc aatcagacaa cataagaagc 2390101 ctttcagcaa acggcttctc tctctgcatg cgcctttttt gtactcttcc cgttctaagc 2390161 aggtgtattt atcagctcat tgtatacatt atttatgttc tttattatag taaaagtgtt 2390221 tttgattcgt caatcatctt ttccaaaaac accgctttct atacagatgg gcaggcacct 2390281 attgcccaag tttacatatg atgcttgtaa atgcgtagag gaggatgcac cgtgaagaaa 2390341 cgtttcagct cttattcgct gccgccatgg gtaaggcaaa ttcggcttgt atccgcacaa 2390401 gtgattattc ccattacgat ttttcaagga atcagaacca ttttctttcc gacaaccttt 2390461 gatgttttgc tgctcgcaat cctaatcttt ttagcttgcg cccttcattt agaatggata 2390521 taaacaaaca agtccgcgcc attaagacgt ggactcgttt tcagcctgaa attttttctc 2390581 ttgttcaatc tgatgaattt tcatcacaaa cggctctatg tttttcattt gccaataagc 2390641 ctttaataat tgtgtacatt cctctttttc atgctgtctt ttcccagttt gataaccgtt 2390701 cagcaccttg tacatggctg ccggatatgc catatagctg agaaaaaggc tgacttccgc 2390761 ttcacgcaaa gggaatgatt tcgtatatcc ataaaaccat tcgacgcatt ccggacaagc 2390821 tttcggaaag cctctgaaca tttttgtata aaagccgagc aggtcgtttt gcggcggacc 2390881 gacagatgct ctttcgaagt ttgtaaaata tccggtcccg gcatcattat acagaaaatg 2390941 gtgtatagac aggctgccgt ggttcattac aacccttgaa acgtcctttt cctttgcgga 2391001 ctcataccag tcctccagcc gttccagcgc aaagttcacc gcggaaatgg tttcagaaaa 2391061 ataggttatg gcctggagtt caaagggaga aaggtaccat tccttctccg ctctatccac 2391121 aaactgctca tagaaaattt tatcttgttc ccactttttt ttcgtttgcc cgtaataacg 2391181 ttcaatctca tcacgtctaa cctttagttc ctgcgcggtt ctctcgtgaa gacgggctgt 2391241 ttctctaaat aaataagcat gtttttgatc ccgttcttcc tcttggtcaa attggagcca 2391301 aggcattaaa tagtagatat ctccgtattg tatgcctgct gagaaaaact caccgctatt 2391361 tgttctgtaa acgggaacga atgaacgaaa gcctttttcc tcaatcgcca ccatatgatc 2391421 tgtaaaatgc ttgccgcgac cttctttcaa ttttttcagg gcaaatatgc cgtagtctgt 2391481 atacactttc caaacaagag gactgacagg ctcaataaat tgagcagtca gtccgtattc 2391541 ctgaagaacc gattgggtat cttccatttc attcaccaca ttttccgatc acttacggtt 2391601 tacgcatggc tatttttata ttgaggaata tagagaatct gtcctgcttt taattcatca 2391661 tccaaggcta aagaattcat cctgatcagc tgctgggatg taatttcata ccgttcgcat 2391721 aaacgctcga tcgtatcttc ctgctgcaca atacaaattt tcattctcga aaactcatcc 2391781 gcttcttttg taaagagttt tgttaaataa agagaattat cactttcctt tgtttgaggt 2391841 tccttcgttt cagcagcagg agcaacccta ggaacagcat ccgtttcctt cctttcagtc 2391901 tcagaagatt caggcagctg gaaggattga aaaggtgttt cttccttagg ctcttcagct 2391961 gatggtgttt ttctcacttc aatttcgaag ctctcttcct cttgttcttc ctcctccagc 2392021 agcttaggcg ctgaataaaa agaatcctcc tcttcttgtt caggcaggaa ggtacggtat 2392081 gccggttcag gcaattcttc ttgagatgcc tcctccgagc ttgttttttg attgaaatgg 2392141 aaatgtaaat cggcattgtc attctccata tatacagctg aagctgtttc tctgctatct 2392201 tctatggaga gagcggcctc tgatacactc tccaaagctt catccggttc cgcctcttct 2392261 tggcaaagcg caggatcagc ctgatccgat tgagctgctt cttcattttg agcctcttgg 2392321 cgcagcgcat attcatgatt aggagacact gttgtttcct ctttttcctt tgcaatcaca 2392381 gtctctgaat gaagctcagc ttccaaagca ggcgattctt ctgctccaac gtgttcacga 2392441 agctcagtct ccgctggaga gtctgcttct tcacgaacat ccgctattgc agctgccggc 2392501 tctgccgttt ctttttttgc tttaacgatc tcttgaatct ctatttctga aggatcaggt 2392561 tctggctcag attcttctgt ttccgattca gcacgaacct ccgtttccgg cacagcaagc 2392621 tcttctgact cttcttcctc tttcacatct tctctggcct ctggttctga agcaaccgat 2392681 tcaggcggct cagattctgc tttttctgtc tccagttctt cacggagccc cgctttcgag 2392741 ataaaaagtt ctggcggttc ggctggcggt tcatgctgaa gaactgcttc ctctgccgat 2392801 gatgcacccg gttcttctac tacactatgt gccggcggct ctgaaagctc ttcctccctg 2392861 aatgccgcag gagcttcata taaaggtatc tccggctctt tgtcttgcgt atcgtccaaa 2392921 agcccttcga tcgctaaatc agcttgaatt gttaaaatgc gcgaatccgt caattgatag 2392981 tcaaatgcgt caataaagac gaagacatcc tgtaaatggc tcactttatt tttcggaatg 2393041 gtaatatcca caggaaaaca gtgagtcagt tccgcacttc catcctctct ctttctgact 2393101 tgttcaacaa accgcttatc tgtataaatc tcttcggtat gtttgttttg atctatgttg 2393161 tactcacctg taagttcaag cgatcctatg attgatacat aatcatttac ttcctgaacc 2393221 ctaatatcag gatctaatga aatagaaagc agttcagaaa cttcctgtcc tttttggaaa 2393281 cagatcgatt cttctacaga aaattgcaat cgatgatttt gcggcaagtt catatcctcc 2393341 tttcatctaa tccttaaaat tagatgtcac taaaggtgta tgtatgaact ggagaaaata 2393401 tgagtgggag agcacgaaaa aaccggcaca aggagtcctt gataccggtt ttcactctta 2393461 tctgcggctg atctcagcaa atactttctc agctgcctgg attgtgtttt caatatcttc 2393521 atcagtatgg gccgttgaga ggaaaagacc ttcgaattgt gatggcggaa ggaatacccc 2393581 ttcatttgcc atccctttat aatagcttgc gaacagcttc aaatcagatg atttcgctgt 2393641 ttcataattg atgactggtt cgtttgtaaa gaagaaaccg atcatcgaac ctgcacggtt 2393701 aaaggtatgc ggaatgccat gagccccggc ggtttttgaa attccttctt ccagtctgtc 2393761 gccttttttg atgaaattct tgtaggattc aggtgtcagc tgtttcaatg tctctaagcc 2393821 agccgtcatc gcaagcgggt tgcctgacaa tgtaccagct tgatagatcg gaccgcttgg 2393881 agcgatctgc tccatgattt ctgcctttcc gccataagcg ccgacaggaa gtccgccccc 2393941 gattactttt cctaaacaag tcagatcagg cgttacgccg aagtagcctt gagcgcagtt 2394001 ataatcgacc cggaagccag tcatcacttc atcaaaaatc agcagggagc cgtactgctc 2394061 agtgatatca cgcagaccct gaaggaaacc ttcttgcggc ggaacaacac ccatatttcc 2394121 ggcaactggc tctacaatga ctcccgcaat gtcttcaccg aattgctgga aagcaagctt 2394181 tacactttct aaatcattgt acggaacggt gatggtgttt ttcgcaatgc cttcaggcac 2394241 ccccgggctg tcaggcagac cgagagtggc aacacctgaa ccagctttaa tcaagagaga 2394301 atcgccgtgt ccgtggtagc agccctcaaa ttttaaaatc ttgttgcggc ccgtatagcc 2394361 ccttgccaaa cggagggcac tcattgtagc ctctgttccg gagcttacca ttcgtacaat 2394421 ttctacagat ggcacacgat caatgacgag cttagccagt tcattttcta cttcagtcgg 2394481 agcaccaaag cttgtcccgt attcagccac ttttttgagg ctttctacga cgcggtcatt 2394541 tgtatgccct aaaattaaag gcccccatga caagacgtag tcaatatatt cattcccgtc 2394601 aatatcaaag attttcgagc cttttccgcg ctccataaaa atcgggtcca tgtctaccga 2394661 tttaaatgcg cgaacgggac tgttcacacc gcccggcatg agtttttgcg cttctttaaa 2394721 agccgttttt gatttttcat agcttctcat ctgcctcaac tcctgtcaac tgaataaaat 2394781 tactccgcaa gccatttcgc tgcgtctttc gcatgatacg taataatcag gtcggcaccc 2394841 gcgcgcttca tgcttgtcaa aatttccaac acaatttctt tttctttgat ccagccgttc 2394901 tgcgctgcag ccttcaccat tgaatactct ccgcttacat tataagcgac gagcggcaaa 2394961 gtaaactcat tttttacgtc acgcatgata tccatataag aaagcgaagg tttgacaatc 2395021 aaaaagtccg cgccttcctc aacatctgat tgtgcttcgc ggagtgcctc catacggttg 2395081 gcagggtcca tctgatatgt tttgcggtct ccgaattgcg gtgtgctgtt tgctgcatca 2395141 cggaacggac cgtaaaactc acttgaatat ttaacagcgt aagacatgat gggaatattg 2395201 acgaatcctt ctttatcaag tgcttctctg atcactgtaa caaatccgtc catcatgttt 2395261 gatggcgcaa tgatatccgc acctgctttc gcttggctga cagctgtctg cgccaaaagc 2395321 tccagcgatt catcattgag aatgactccg tctttgacaa gtccgcaatg gccgtggtct 2395381 gtatattcgc acaggcacgt gtcagcgaca acaaccattt cagggaagtg ttctttaatt 2395441 tctgtgatgg ctttttggac aattccgtga tcatggtacg cttgtgttcc gcaatcatct 2395501 ttttcttccg ggatgccgaa cacgataaca gattgaatgc ccagtttgac cagctccgct 2395561 acttcatcct tcaataaatc taatgataca tggtgaacat caggcattga cggaacagct 2395621 tttttgcctt ccagcccttc aacgacaaaa atcggatata taaaatctga tggatgcaaa 2395681 cgtgtttcct ttaccatttc tctcattgct tttgatgtcc gcaggcggcg gtgtctatta 2395741 aatgattgac tcatattctc tcttcctctc ttgacatgct gcacattaac tcaagcatgc 2395801 catctattgt aaatgtatca ggcgtatgcg atgtgatgcc gtacgtcaga agggcatcat 2395861 ttgttaaagg cccaatgctg atacaggccg tcccattcgc cttccacttt tttaattctt 2395921 ctcccaagac atgcataaac gtatgtacgg ttgatgaact cgtaaatgtt acatagtcaa 2395981 aggaatattg acccgcagcg tctttcaatg cctcaatgcc ttcttcatcc ggaatcgttt 2396041 cgtagagaac ccattccttt acttcaaaac cgagcgggac aagctcttgt tttatcacat 2396101 cacgtgacaa attccctttc atcacggtaa tggtctcccc cggttcagca tgctgcttaa 2396161 gagcgtcagc caattgttca gcaatatact cctgtggcat cacatcaacc gatacgttat 2396221 gcatttttaa acggcgcgcg gttttttcac cgacggctgc aattttttta tgcgcaggga 2396281 gaataagctg attttccttc agataagaaa aaaagaagtc tgccccgttc acacttgtaa 2396341 aaacaagcca gcctggcgcg gcaagatcct ctcttacctg ttccgcaaca tcattcggca 2396401 aagcgcggcg aaacgtaatc aaagaggtta aaaccgcttt accgccaagc gcctccactt 2396461 tttgctgaaa tgatgctgcc tgtgccttat tccgggtgac aagcactgtt tttcctttca 2396521 acggaaaatc attttccatc ctcgtcaagc tcccgtttta cacgatcaat taaatctttt 2396581 gctcctttgt cagccataag agcggcacag cgctttccta cttcctccgg atcgtttccg 2396641 gtgacggttt ctttaaaaat gattttgccg tcaggtgaag cgacaagacc tgtcatttca 2396701 atttcatcct gtccatttaa cacggagtag cccgcgatcg gaacctggca gccgccctcc 2396761 atcgcgttta aaaaagcacg ttccgctaag acagtccgtt ttgtatattc atctgtaaac 2396821 tgagaaaaca acgccaacag ctcttcatcc gattctcggc actcaatcgc cagggctccc 2396881 tgccccacag caggcaaaca gcgctcaggc tcaaggaatt cggttacgac atcttgcttc 2396941 caacccattc tggaaaggcc ggcagccgct aaaataattg cgtcataatc ctctgtttcc 2397001 agcttttgaa gtcttgtatc tatattacct ctaatccatt taattgtaag gtcagggcgc 2397061 tcaatcaaaa gctgcgcgct tcttcttaaa ctgcttgtgc caatgacagc acctttcttc 2397121 atttctgaaa gctttacgcg attctttgaa ataagggcat cacgcgggtc ctcccgttca 2397181 ggaatacagc cgatcacaag gccttcaggc aaaacagcag gcatgtcctt catgctgtgc 2397241 actgccatat caatctcttc gtttaaaagc gcctgttcaa tttctttgac aaaaagccct 2397301 tttccaccca cttttgagag tgtaacatcg acaatccggt cgccctttgt cacgatctct 2397361 ttaatttcaa aagcaaacga aggattgatt tccttcagtt tttgaataac ccattttgtt 2397421 tgagtcatag cgagtttgct ccgtctggaa cctactttaa tcgttctcat catttctttc 2397481 ctcccgaatc tgcttgggac atcgtttaac tgaaccaatg gaattgcgac aggcttccaa 2397541 gcaggaaata attgatcatc agcaccagaa aacaagccgt attccacagt gcagcgacct 2397601 ttccttgcag ctccttaatc agcctgatat aaagataata gctgtacagc agcaggacga 2397661 caaacgaacc aagcactttg gcgtcaaacc aatacagcgt ttctagtgag acatacgccc 2397721 aaatgacgcc gagaatcaaa ctcagcagca gcatcggaac cccaatgaca tttaaaacat 2397781 acgccatata atcaagctta gataaatctt ctattctcaa cagccatttt ccccactttt 2397841 tctttttcag cagatgatat tgaaacatat atagcacaga aaaaacgaaa gaaagggaaa 2397901 aagcgccgta tgaaagaatc gccattgtaa tatgaatcac caaaagctcg gatacaagct 2397961 gcccggaaaa agcagctgac tgctgctctg tcggtgaaaa tgtgtgaatg gcgatcatag 2398021 aaaatcctat aacatttgta aaaaacacga taaagtcaac acgtaaaagc tttgtcagta 2398081 caagtgacag cgtgacaagc acccaggcat aaaaataaag tgcctctgtc acatttaata 2398141 ccggaaaccg ccccgtcacc cacataaaat aggccaaata cacggtttgc agagtccaga 2398201 caatagaaag caaccagaag gccatttttc cagccttccg gttgtgttga agaaaatcta 2398261 taaaataaaa gagtacactt aacgcgtaaa tgacgattgt cccctcatta agtcttgcca 2398321 ttgcagtatc aatcattcag ctttcactca cttacaagtg ggctaaagcc cgcttttgat 2398381 tcagccttct taaaagagtg gaccttctgg ctgctttcaa cggttttcat catttgacgg 2398441 cccgcagctt cttcaatatc aaaaatctgc ataaacaacg cgagcttttc ttcagaatca 2398501 gcatctgccg caagctcttt cacctttaaa atcggatcac gaagcatttg gttaataata 2398561 cttttggtgt gtttgttcaa cagttttttc tctcttgtgc ttaagtgagg cagcttacgc 2398621 tcaatgctgt ccatcgtttc tgactggatg gcaagcgcct tttcgcgcaa tgcagaaata 2398681 acaggcacaa caccaagtgt attcatccat tgtttaaatt ccacaatggt ttcttcaatt 2398741 aacagttcaa ctttttcagc tgtttctctc cgctctttca tgttcgcttc tacaatgcct 2398801 tccagatcgt cgatatcata aagaaaaaca ccttcaagat cattcagcgc cggatcaaga 2398861 tctctaggca cggcaatgtc gaccataaac agcggacgtc ccttgcgaag cttattcgcg 2398921 ttttccatca tctctttgga cacgacaaat tcacttgcac cggttgaact gattaaaata 2398981 tcagcctccg caagcgcgct ttcaagctga ttcaagcttc tcgcttcacc tgaaaaacgg 2399041 tctgcaagct ccttcgcttt caagtatgtt cggttaatga cagtgacctt gccgattccc 2399101 tgtccgtgca ggttttccgc agcaagctcg cccatttttc ccgcaccgag aatcaatatg 2399161 tgcttgcttg aaagatttcc gaagattttt ttggcaagtt caactgcagc atagcttact 2399221 gacaccgcat ttgagccaat gtctgtttcg gcgtgagtcc gtttgcccac tgtaactgcc 2399281 tgcttaaaca gctcattaaa aatagtcccg atcgtttttt cttgctgagc tgttttaaag 2399341 ctgtcgcgta cctgtccgag aatctgcgtt tcgccaatca ccatagaatc aagtccgcag 2399401 gctacacgga ataaatgctc aacagcggca tcgctctcat aaaacgttaa gaacggtgac 2399461 agctcttctt tgcttaattg aaaccaatca gctaaaaact tttttatata ataacggccg 2399521 gtatgaagct ggtcgactac cgcataaatt tcagtgcggt tgcaggttga gacaatgatg 2399581 ttttcaagaa tgcttttctc ttctttcagc tgcaccattg cttctgccag ctcattcggc 2399641 tgaaaactta ctttttcacg tatctcaata ggggcggatt tataatctac tcccacaaca 2399701 agtatatgca tcgctctaat tacaccccca acacccaatc ttaatttata atcattctaa 2399761 catagaactc attatttata ataattataa catagtttct ttcacaaaat gtgaacagat 2399821 tttaaaattc ttatgctata ttagaaaaag cttcagggaa aagaagcatt cctattgaca 2399881 ataccaaaaa cagcagaaat ttactacaca tcagctctaa aaaacaagaa ggtgatatgc 2399941 atgaaacaaa aatcaatttt attcccttgt ctgctgcttg ccgcttctgt atatgcatgg 2400001 ctagaaagcg gccaagccga actgttttca gggcaggatc aatggcctgt tctcctcatg 2400061 ctgttaggcg cagcctttgt atatcaagga aaaaaagaag ccgtcacacc ccattttttt 2400121 atcggtttgc ttctcttcgg gatcggttta cacttttttg ccaagccgaa atgggtatgg 2400181 tggccggatg attttgaaat gctcctcttt atgatcggct tctcacttct cgtttcaacc 2400241 gttcaaaaaa aagaatatgt atatgaagct gtgtcgatga tttgtttttc cctgtttttg 2400301 tactttttca aacaaattat ggcatggctt gagtctgcgc atattccaac agcgcttctg 2400361 aaggagtatt ggccgtttgt ctttattgga atcagtttat tgttattatt gataaaacga 2400421 aaaaaatcta tacgataaat aaaaccggta gaggatcctc taccggttta tcattttttt 2400481 gatcgctccc caagcttcgt cttttccctt tttcgtttct gaagaaaaga ggatcagctc 2400541 gtcttccgga tcaatattta atgtttgtcg gacaaccttc gcgtgtttgt cccatttacc 2400601 tttcgggatc ttatccgcct ttgtagcgat aacaataaca ggaatgccgt aatactttaa 2400661 aaattcatac atctgtacat catcattaga tggcgcatgc cgcaaatcaa cgatctgcac 2400721 cacagctttt aattcctcgc gtgtcgtgat ataggtttca atcattctgc cccatgcttc 2400781 acgctcagac tttgacactt tggcaaaacc gtagcccggc acatccacaa aatgcagctc 2400841 atcattgata atgtagaaat taagcgtttg tgtttttccc ggctttgatg acgttctcgc 2400901 aagatttttg cgattgatta atgaattgat aaaagacgat tttcctacgt tcgatcttcc 2400961 ggccaatgcg atttccggaa gccccccttc agggtactgt tccggtttta ctgcactgat 2401021 cacgatttct gactttgtga ctttcatttc ttctctccta ctaaggcatg ttccaaaacc 2401081 tcgtctaagt gggacgccaa tataaatgtc agcccctccc tgacgctttc cggaatatcc 2401141 tctatatctt tttcattatc tttaggcgca ataatggtcg ttaatcccgc tctatgtgcg 2401201 ccaagcgctt tttcctttaa gccgccgatc ggcagcacgc gcccgcgaag cgtgatttcc 2401261 ccagtcatgc cgacttcacg cgaaaccgcc cgtcccgtta aagcagaaac aagcgctgtt 2401321 gccatcgtaa taccggctga cggaccatct tttggcaccg caccctctgg tacatgtata 2401381 tgaatatcat acttctcatg aaagtcaggt tcaatgccaa gttcttctgt tttggatcgc 2401441 acatagctga atgcagcctg agcagactct ctcataacat ctccgagctt tcctgtcagg 2401501 attaatttcc cttttcccgg tgaaagcgat acttcaatcg aaagcgtatc tccgccaacg 2401561 gttgtatacg caagccctgt cactacacca acttgatcct ctgtttcagc ttgtccatat 2401621 ctgaaaatgc gttttccgat aaaatcttga aggttcttct cagtaaccgt aattcgtttt 2401681 cgctcttcag caacaatggc ttttgcagct ttacggcaaa ttgcggcaag ctggcgttca 2401741 aggcttctta cacccgcttc tctcgtatag taacgaataa tatcaagaat cgcctgatca 2401801 cgcagctgaa gattgctttt cttcagcccg tgttctttga tttgctttgg aagcaagtga 2401861 tcctttacaa tttcaagttt ttctatttct gtgtagcctg cgatattaat aatttccatt 2401921 ctgtctctga gcgggcccgg gattgtggcc aaattgttcg ccgttgcgat aaacagcact 2401981 ttggataaat caaaggtttc ttcaatatag tgatcactga agctgctgtt ttgctctgga 2402041 tcaagcactt caagcatagc ggatgatggg tctcctctaa aatcagatga cattttgtca 2402101 atttcgtcta ataagaagac cggattcagc ttgcccgctt ttttcatccc ttgaataata 2402161 cgtccaggca ttgctccgac ataggtccgt ctgtgtccgc gtatctctga ttcatcccga 2402221 actcctccga gtgagattct gacgaatttg cgtcccaagc tttttgcaat tgatttggct 2402281 aaagacgttt ttccgacacc tggaggtcct gccaaacaga gaatcgggcc tttcagggat 2402341 tttgtcagct tctggacagc caaatattct aaaatacgtt cttttacttt ttcaagcccg 2402401 tggtgctctt cgtccaagag acgtcctgct tctttcaaat caagcttatc atctgtttca 2402461 tccgtccacg gaagagcaac cagccagtcg atatagttgc ggatcacaga gctttccgca 2402521 gaacttgacg gaattttttc atatctgttc aattctttaa gcgctgtttc tttcacatga 2402581 tcaggcatgc ctgcttcttc gattttttcc gtcagcgtct gaacttcgcc agttttgcct 2402641 tctttatcgc caagctcttt ttggatcgcc ttcatttgtt cacgcaagta gtattccttc 2402701 tgcgtacgct ccatcgaacg tttgacgcgc tggccgattt ttttctcaat ctccagcact 2402761 tctttttcat tattaataaa atcaatgacc ttgttcagcc tgtctttgac atcagccgtt 2402821 tctaaaatat cctgcttatc ctttagttta aggggcagat gagaagcaac gatgtctgcc 2402881 attctccccg gctcttcgat atcagtaacc gcagcgtacg tttcggccga gattttttta 2402941 gaaattttta tgtactgatc aaagtggtct agcaaagtcc gcatcaatgc ttcgtcttct 2403001 gtatcttttg aatcatcttc atgaataagt tgaatgtcaa ccgacgtgta atcctcgtgt 2403061 tcattgtatt tgacgatatg ggcgcgcttg aggccctcca ccaacacacg aatcgtaccg 2403121 ttcggaagct tcagcatttg cttaattttt gtataggtgc cgacagtgaa aatctcgtct 2403181 tcaccaggtt cgtctatcga aatatcctgc tgagtggcta aaaatatcat atgatcatgc 2403241 atcattgcct gttcaagagc ctgaaccgac ttgtcacgtc ctacatctaa atgcaaaacc 2403301 atcgtcgggt acactaataa acctcttaaa gggaggagcg ggatgctgcg ttttaattct 2403361 tctgccatgt gactgacacc tccgtgactt tagtatgaac cattataata caactttttc 2403421 atccttgtac aataaacggc atggttccat tttctataaa acagtctcct cgtagtatac 2403481 cctttctttc tgatatgaaa aaggaaaaga tgtccttcat gaaaaaaacc ctattatcaa 2403541 aatagggttt aaacggattc tttattgatt tcgatatgaa acggtttttg ttccgttggc 2403601 ggattcacca aaatttcatc aagcacttct tggaacgtct tcactgcaat aatctcgatc 2403661 ccgtcaatct gctttaagat ggcctgctga ttttcatatg ggataatcac ctttttcgca 2403721 ccggactgct tggccgcttt tattttcgga atgacgcctc cgatgggttt cacaagaccg 2403781 ttcaggctga tttcgcccgt catcgcaacg gtattgtcaa taggaatttt gtgtatcgcc 2403841 gagaaaatcc ccgccgccat cgcaatgcct gctgacggcc catcaatcgg aatccctcct 2403901 gggaaattga tgtgaatatc ataatcagaa ggcttcattc ccattgtccg gagcacggtt 2403961 aatacatttt caaccgaacc cttcgccatg ctttttcgcc tgatcgattt tgattggctg 2404021 ccgatgcttt cttcttcagc tattcctgtg atgttaattg atcctttatc ttgagccgcg 2404081 gttacactta cttcgatttc cagaagcgat ccgctgttag gcccatagac tgcaagccca 2404141 tttacaatgc caacctgtgg ttcaacaccg attttttgct cgtgctttgg agtaagctga 2404201 ctggagtgaa tgacccattc aatatcctca atcgtaatgt cctttcgatt ctccgttaca 2404261 gccatccccg ctgcgatttg aatcatattg acggcttccc gcccgttccg cgtgtagctg 2404321 gtcaaaagat ccagtccttc ttcggagata tttttttcaa ttttatccgc tgctgttttg 2404381 gcaaccgttt tcagctcgtc cttttcaagc tcgcggaaaa aaacctccaa acagcgggac 2404441 cggatagctg gcggaatttc gtttggcatt ctcgtggtcg cgccaatcaa gcgaaaatca 2404501 gccggcagcc cattttgaaa aatatcatga atatgattcg gaatttgtgt attttcctca 2404561 ctgtaatacg cactgtctaa aaagactttt ctgtcctcaa gcaccttcag cattttattc 2404621 atttgaatag gatgcagctc ccctatttca tcaataaaca gcacaccgcc atgggcatgg 2404681 gtgacagctc cctgcttcgg ctgcggaatc ccagcctgtc ccatcgctcc ggccccttgg 2404741 tatatcgggt catggacaga gccgatgagc ggatcggcaa ttcctctttc atcaaaacgg 2404801 gctgttgtcg catcgagttc cacaaagaca gcctgctctt taaacggtga ttgtttatgt 2404861 ttttttgctt cttccaacac aagccgcgca gcagccgttt tcccaactcc cggtggccca 2404921 tagacaatca catgctgagg atttggcccg cataaagccg cctttaatgc tttaatgccg 2404981 tcttcctgtc cgacgatatc tttaaagctt ttggggcgga ccttctcaga taatggctcg 2405041 gacaagctga tagcgcgcat tttccgaagc tgctccattt ccttctttga ttctttatct 2405101 atcgtgacct tttgtgtcct ttgattttta agcaaattcc aaaaatacaa accgatgatg 2405161 atcccaaaaa acagctgaat aaataacgcg atccctgtcc aactcatggt ggtccctcct 2405221 gaaaaacaat ttatgtatcc aattcattcc tctgattgct agtatctccc atagaagacg 2405281 ggaataaacg tttttccgga agagttgcat gcaaaaaaac ctcctgagtg ttaccactca 2405341 ggaggtttgt gcttatcttt atgcagatgt tttatcttgg cttacctcag tgccgtcttt 2405401 taataagagg cgaggaggct ctccgtgtgt cacagttgcc ccggtgatta cacatttttc 2405461 aatgtcatca cgagaaggca gctcaaacat cacatcaagc atgatgcctt caatgataga 2405521 acggagtccg cgtgctccag tcttgcgttc aattgctttt ttagcaattt cagaaagcgc 2405581 ttcttcttca aactcaagct caacgttgtc aagctcaagc attttcttga attgcttaac 2405641 aagagcgttt ttcggttttg ttaagatcgc aaccaatgct tcttcgtcaa gcttttcaag 2405701 gcttgcaata accggaagac gtccgataaa ttcaggaatt aacccgaaac ggagcaaatc 2405761 ttctggaagc acttttgaaa gaagatcttc tttctcaaga tcagcagctt tattgtcggc 2405821 accgaatcca atcacttttt ggcctaaacg gcgtttgatg atttgttcga taccatcgaa 2405881 agctccgccg caaatgaaca aaatatttgt tgtgtcaatt tgaatgaatt cttgatgagg 2405941 atgcttacgt ccaccttgag gcggtacgct tgccactgta ccctcaagaa ttttaagcaa 2406001 tgcctgctgt acaccctcac ctgacacatc acgtgtgata gacgggtttt cagattttct 2406061 agccacttta tcgatttcat caatatagat aatgcctttt tcggcttttt ccacatcata 2406121 atcagcagct tggatgagct tcaagagaat attctctaca tcttcaccca cgtatccagc 2406181 ttcagtcaaa gatgtagcgt ccgcaatcgc aaacggcaca tttaaaatgc gagccaatgt 2406241 ttgcgccaga agggttttac cgcttcccgt agggccgatt aatgaaatat tactttttga 2406301 aagctcaaca tcatcaactt tgctgttgga gttaatgcgc ttatagtggt tatacacagc 2406361 aacagcaagt gatttcttcg cttgatcttg gccgatgaca tattcattca aaatttcgcg 2406421 aatttcctga ggctttggta cgtctttaaa ttctacttct tcttctgttc cgagttcttc 2406481 ctctacaatt tcagtgcaga gttcgataca ttcgtcacat atatatacac caggtccagc 2406541 tacaagctta cgaacctgat cttgtgtttt tccacagaac gagcatttta attgtccttt 2406601 ttcctcgtta aatttaaaca ttctttcacc ccttaatctt gtctcacttt ttcttttacc 2406661 ggcagagcaa aagaaaatga ttcttgaaac gaacgagtat gtattgcatt ttaccatact 2406721 ttccaaaaag acggtaacaa tgtgtttctg acttgcacat tctatatgta tgacaaaaaa 2406781 cagccctgca ttaactatat tgccccaaga aaaagagata actcataatt gtacaaaaca 2406841 aggcacgaat gattcgcgcc ctgttttatt agtactatta ttatgcacca tattaacggt 2406901 tttctacaag aaaatcaatt gctttgcgaa cttttaaatc ttctttcatc gcgtcagtag 2406961 aaccgatggc ttgtttaata ttttcaacag gcatgttgta tgcttcagcc atttttgtaa 2407021 gctcagcatc aacttcctca tctgatactt caaggttttc cgctttcgca atcgcctcaa 2407081 gagtcaggtt agattttacg cgtttttcag catcttcttt catttgctct ttaagcgcag 2407141 cttcatcttg gcctgagaat tgagtgtaaa gctcaaggtt catgccttgc atttgcagac 2407201 gctgttcgaa ttctttcagc atgcggtcaa gctcagtgtc gaccattgct tgaggcacat 2407261 cgatttcagc attttcagaa gctttcagaa caagctcttc acgcaattta gcgtcagctt 2407321 cgttttcttt tgcttcttct aaacgtttct ttgttttttc agttaattca gcaagtgttt 2407381 ccacttcttc atcgatatct tttgcgaatt catcgtcaag ctcaggaagc tctttcgctt 2407441 tgatttcgtg aattttcact ttaaacacag ctggtttgcc tgcaagatct tcagcgtggt 2407501 actcctcagg gaatgtcact tcaacatcct tctcagcacc tgcttcaagg ccaactaatt 2407561 gatcttcgaa gccagggatg aatgaaccag aacctacttc tagagagtag ttttcagctt 2407621 ttccgccttc gaaagcttcg ccgtcaacga atccttcgaa atcaagaaca actgtgtttc 2407681 cttcttcaac ggcgccttct tcttttacaa caagctcagc ttgacgctct tgaagggctt 2407741 ttagttcgtt ttgaacatct tcgtcagtta cagttgtgtc gtctttttca atgcccaggc 2407801 ctttgtattc gccaagcttc acttcaggtt ttactgttac tttcgcagtg aagattaagc 2407861 tttcgccttt ttcgattttt tcaacatcga tttcaggacg gtctacaggc tcgattccag 2407921 cttcttcaac cgctttaggg tattctacag gaagaagaat atccaaagca tcttggtaaa 2407981 gagcttctac gccaaagcgc tgttcgaata atccgcgagg aattttacct ttacggaatc 2408041 caggaattga aacttgtttt actacttttt taaatgcatc atcaagtgct gttttaaacg 2408101 tttcagcatc aacttcaacc gttaaaacgc cttcgttgcc ttcttgtttt tcccatttta 2408161 cagacatgtg tttccctcca aaaatctatt caggttgtgt cggtcttcca ttctaaagca 2408221 atcattcggc ttcgtccaac aaaaacaaag ctgccaaaga tcagaatcat tatgtataga 2408281 tgttaataat gaactgcaaa gcctgtccaa ccgtatttct tataacccgt tatacacaaa 2408341 tacaaccact atattataac ataacacata gcgctttcaa ctatatggcg cgatttacaa 2408401 ataagaaatt tcttcaatat cttttaacat tgtgcaagct tcatcgagtt ctctgtctgt 2408461 aaattcatac atcatatgaa gttcttcgct ttcaatttca atcccgtgca tctcgtaacc 2408521 gactttatga agggcagccg cccaaaggtc agccgacagc aatttcggct ggaacggata 2408581 taaaacgtac aaatgtcttc tccacaattc ttctactgct gcatataagg ttggattttc 2408641 atttccaagt gtctcatcta gcaccctgag aacacggtga agaatcggcg cggcatcagg 2408701 cggaacaatc tctgacggtt caattgtcaa cgactcgcca aatttactaa tgtgtacagg 2408761 tttactgtac tcatgctcag ccaacagcat gacaatcatc gttttgataa tcggatgggc 2408821 tgaggggtct tggaggattg ttttgagcaa tcctgtatac tttgctacgt tacggtcttt 2408881 taaggaatga atgagattca tttgctcctc agggcttgcc agcactttct cggtgtcaat 2408941 tgtatcctca tattcttcgg cccaagcctc gtcctcacga tccggatcgg tcattttccg 2409001 gctgaaatcc agcagcttat aaaattgctc ggcactttct gccggcagct gattttcttc 2409061 caaaacggct tcaatggtgc ttttgacttc ttcgtacttt ttgagctgaa ttaagatggt 2409121 catgtacacc tgcaaaaccg taaaataatg gccataacct tctttgagca tcttctcgca 2409181 cacgctttct gcctcttcca gctcgcccag ctctaaaaag cagatggcca tccctaagtg 2409241 aagatcggat tcagtatcat catatttcat cgcttctgaa aacagttcaa gcgcttcttg 2409301 atactttttt tccttgagtg atgacatccc tttttccaca aggcggtctt tcagatgagg 2409361 aaaaggaata atttttgcgt ttttcttgtc atgcgtcata cctatattcc tttcaggcat 2409421 ttattttgtt caagtgtatc aacacctgtg aacaaaaaca agaaatgaaa ggtttcacca 2409481 ggcaaaaaaa gccgccggac aaataccggc cgctttttca ggcttgaagc caagagcttc 2409541 tttgtgattc aaattgcttg atttcatctt ccagcagcag cgttaatgaa atttcatcat 2409601 atccgttgat cagcatctct ttccaatgcg gatcaacttc aaatgaaatt tgattgcctt 2409661 cactgtcatg aatcagctga ttttcaaggt caacagtcat ttgcaatgac tggttttcat 2409721 actggccgac aagctgtttc caattgtcat atggcatgcg gatcggaagc atgccgtttt 2409781 taaagcagtt ctgatggaaa atatcagcga atgacggcgc aatgataatt ttaaacccat 2409841 aatcatcaag tgcccacgga gcgtgttcac gcgatgaccc gcagccgaag ttttctcctg 2409901 ctattaaaat ggaagctcct tgataaacag gctggtttaa ttcaaattca gggttcggtt 2409961 caccattcgc atcatatctc cagtcaaaga atgcaaaacg tccgtagcct gttctttcaa 2410021 tcctcttcaa aaattgctta ggaataatct ggtctgtatc cacattgatc cgatttaata 2410081 cggctgcttt ccccgtatgt gatttcaaag gttccatctc gcgcactcct tacacaactg 2410141 ttttttcctg ataaaacttt ctgacatcaa cgaagtgtcc gtgaatggca gccatcgcag 2410201 ccattgccgg gctgacgaga tgtgttcttg caccttttcc ttgtctgccc tcgaagttgc 2410261 ggttagaggt tgatgcacag cgctctccct caggaacaac atcattattc atactcaaac 2410321 acatgctgca gcctgactct ctccattcaa atccagcttc caagaaaatc tggtcaagcc 2410381 cttctttttc agcctgaagc ttcacgcttt gggatccggg cacgacgatg gcccttacgc 2410441 tgtcagctac cttcttccct ttgatcatgt cagcagcctg tcgaaggtca gtcatgcggg 2410501 aatttgtgca ggaaccgata aatacgtgct ccactttaat gtcttcaatt ttttggtgag 2410561 gagtcaatcc catatattca taagcacgaa tcgcttcttt tttatcgtct tctgcagaaa 2410621 agctttccgg cgcaggaact tcagaatcga caggaagaac cattcccggg ttaatgcccc 2410681 atgtcaccat aggggaaatt ttgttgccgt caaggacgat agatttatcg taaacagcgc 2410741 ccgggtctgt gcgcagcgcc ttccattcct ctacggcctt gtcaaattct tcgccttttg 2410801 gcgtgtactt gcgatttttg caatattcaa acgtcacctc gtcaggtgca atcaaacctg 2410861 ctcttgctcc tgcttcaatt gacatgttac aaacagtcat tcgttcatcc atcgtcatat 2410921 ttctgaatac ttccccagtg tattcaatga cgtagcctgt gccgaatttc acaccgtatt 2410981 tgccgatgac agcaaggatg acatcctttg ccgttacccc tttttgaagc gttccatcta 2411041 cgcgcacttc aagtgttttt ggacgctgct gccaaagtgt ctgtgtggaa aggacatgtt 2411101 caacttcact cgtcccgatt ccaaatgcaa gagcgccgaa agcgccatgt gttgatgtat 2411161 gactgtcacc gcacacaatc gttttccctg gaagcgttaa gcctagttca ggtccgacga 2411221 catggacaat cccttgatcc acactgtgaa gatcggcaag gcgcacgcca aattcctcac 2411281 agtttctttc aagcgccgtt acctggcgtt tcgcaacttc atcctttatc tcaaaacgat 2411341 tgacagtcgg gatgttgtgg tccattgtcg caaatgtgtt ttggggtctt ctgacctttc 2411401 ttcccttttg tctcaagcct tcaaatgcct gaggagacgt cacctcatga atgaggtgca 2411461 aatcaatata gagaagatcc ggctttccct caccatgttt tacaatatgc tgatcccaaa 2411521 tcttttcgat gattgttcga ggcatcatct tttatttcct ccctctacct agagctaaga 2411581 ccgcttaacg taagctgtca cacattagaa attgtatttt cactcatgat tgctgcctta 2411641 acttcctctg taatggcctg agtgctgctg aactcttcac tccgtgccaa gtctcttgtt 2411701 ctttttccag aagccaagac tttgtttacc gcatcttcta cagctttcgc ttcctcttca 2411761 agcccgaaag atgttctcaa aagcattgcc gctgacaata tggctgcgaa cggatttgcc 2411821 atccctttac cggcaatatc aggcgcggag ccatgaacag gttcaaacag atgaaggcca 2411881 gagcttgata ggctggctga cgggagcatt ccgagcgagc ctgtaagcat ggacgcttca 2411941 tcgcttaaaa tatcaccgaa catattttca gtcaccacga catcaaattg attcggtgca 2412001 taaattagct gcatggccgc gttatccaca agcatgtgct caagcttcac atcaggaaat 2412061 tcttgtgcaa cgtcctcagc cacttcacgc cacagccggc ttgattcaag aacattcgct 2412121 ttatctacag aggtcacttt gccttttctg gctgccgcca ttttgaagcc ctctctgatc 2412181 actcgttcaa tttccgttcg cttataaaac agtgtatcta ctgcttcctg ctcaccttca 2412241 gtgtttacat aacgtttgct cggctggccg aaatacaagc cgcctgtgag ctcacgaacg 2412301 ataacgaaat caacattatc tatatattct tttttcaaag gcgaagcgtc agaaaggctt 2412361 tcaaatacct tcacaggccg caaattcgca aacaaatcaa gctgttttct gatgctgagc 2412421 agcccttttt ccggtctcag ttccgaagga ttttgatccc atttcggtcc gccgacagca 2412481 ccaagcaata tcgcgtctgc atttttacaa gcagcaacgg tttcctccgg gagggggtta 2412541 tgatgttcat caatagccgc ccctccaatc aggccatatt caaattcaaa ttcatggtta 2412601 aagcgttcgg caacactttt cagtacgtct gtcgctgatt ctaatacttc agggccgatc 2412661 ccgtctccgg gcaatagagc aatacgtttc ttcaagttaa ccgttctcct ttcttttatg 2412721 atccgacagc tgtgtggttt ttcaatccgc tcatattcga ctggaaaacc aattgacggt 2412781 ttactgcgtt caaataggct ttcgctgatg cttctaatac gtcttgcgct atgccccgcc 2412841 ctgctgattc ttttccgttc accaaaactc ttacatacac ctgggcaaat gcatcttcgc 2412901 cttttctatt agactgaatg cggtagtcta agagctccac atccttatcg atgcagcgct 2412961 caagcgtatt gtagattgct tccacgcttc cagctccagt tgcagcttcc tgaataagct 2413021 gtgcgttttc ttgatttttc aaagatagag tagccgtagg gacctgactt gttccgtaat 2413081 gtacttgcag agaaagaaat tcatacccaa tcttgcgatc tgttactttt tcttctaaaa 2413141 taagagaaac aagatcctca tcagtgattt cttttttctt ctcagtcaac tctttgaaca 2413201 tcgtaaagaa tttattaatc tcttcactgt caaattggaa tcctaaagca gtcagccggt 2413261 ctttaaatgc gtggcgtccg gaatgtttac ctaggacaag cgcatctgcg gttacgccga 2413321 caagctccgg tgaaataatt tcataagtcg atttttcctt taaaaagccg tcctgatgga 2413381 tgcctgattc atgagcaaat gcattatctc caacaaccgc tttgttgcgc gggacagcca 2413441 tgcctgtcag tttgcttact aaatcacttg ttctcttaat ctcgttcagc gtaatacctg 2413501 tttcgacttg gtagaaatct tttctggtat ggagggctac ggcaatttcc tctaatgccg 2413561 cgtttccggc tctttcaccg atcccgttca cagcgcattc gatttgatca gcgccatttt 2413621 caatcgcagc aagagagttt gcgactgcca ttcccaaatc atcatgacag tgggctgaaa 2413681 gctttgcttt gtgaatgttc ggaacgtttt ctttcatata tttaaagata tttccgtatt 2413741 ccgccggggc caggtagccg acagtgtccg gaagattgat aacactggcg cctgcgtcaa 2413801 tcactttctc gacgatttct gctagaaacg gcagttcagt gcggcaggca tcttcagctg 2413861 accattgcac aatcggaaaa cgttcttttg cgtatttcac cattccaact gctctttcaa 2413921 tgacttgttc acgtgtcatt ttcagcttgt gcttcaaatg aatgtccgat gtcgcgataa 2413981 atacatgaat tcttggttga gcgccatcct ttaacgcttc ccaagcagca tcaatatcac 2414041 cttttacaca acgggccaga ccagttactg aacaattttt aatggttctt gcgatttcct 2414101 gaacagctaa aaagtcacct cgggacgaag cgggaaatcc cgcttcaatg atgtctgccc 2414161 cgagtctttc gagctgctta gctatggcaa gtttctcctg tgtattcaag ttcactccag 2414221 gggactgttc accatcacga agcgtcgtat cgaaaaaatt aattttgcgc aacggagacc 2414281 accgcttcct tcttcttgcc ttgtttcaca aacggcatca tttcacgaag ctttcttccc 2414341 actacttcga tttgatgttc gttctcgctt gcattgatag cgttgaaacg aggacggttt 2414401 acttggtttt cgacgatcca ctcttttgcg aatgtaccgt tttggatatc ttttaatact 2414461 tctttcatag attcttttac tttggcgtcc acaacgcgag ggcctgatac gaaatctccc 2414521 cactgtgctg tgtcagagat tgaatatctc attcctgcaa gtccttcttc gtacataagg 2414581 tctacgatta atttcagctc atgaagacac tcgaagtatg caagttcagg ctgataacct 2414641 gcttcagtta aggtttcaaa tccggctttg acaagcgcgc ttaatccgcc gcaaagaact 2414701 gcttgctcac cgaacaaatc tgtttctgtt tcttctttaa atgtcgtttc taatacgccc 2414761 gctcttgcgc cgccgattcc tttagcataa gcgagggctt tgtctcttgc ttctccagtc 2414821 acatcttgat agattgcgaa caatgcaggt acgccagctc cttgctcata tgttcttctt 2414881 accaagtgtc ccgggccttt aggggccact aagaatacat ctacatccgc cggaggaaca 2414941 atttgatgga aatgcacgtt aaatccatga gcgaatacta atgattttcc tgctgtcaat 2415001 tcatctttga tttcagcttc gtatactttt tgctgctgct catccggaag cagaaccatg 2415061 atgatttcgg cttgggctgc cgcttctttt actgaaaata ctttatgtcc gtcttcttgg 2415121 gcttgagtga aagattttcc ttgtctaaca ccgacgatca cgtctactcc gctttcttta 2415181 aggttcaggg catgtgcgtg gccttgcgaa ccgtacccga taaccgctac tgtttttcca 2415241 gccaatacgt tctctttgat atcaccgtta taatatactt ttaccatttc aatctctccc 2415301 ttgttatgtt ttatacaata gatattgttt tattggatga cgccttttgc tgggttcccc 2415361 tcgcaaaagc cgttgtacct gttctcgcga tttctttaat gccataaggt tttaataact 2415421 caataagcgc ttcaattttg ttagattcac ctgtcacctg aacaacgatg ctgtctctgc 2415481 tgacatcaac gacagaggct ctaaacggtt ctatgattcc attaatctct gttcttgttg 2415541 aaggtgcgga gacaaccttg attaaggcca gctccctctg gacaatcgat tgatttgtga 2415601 tgtctgtgac tttcagcaca tcaatctgtt tgttgagctg tttcgttaac tgttcaacat 2415661 cattttcacc ttcaacatga acgacgaagg tgattctgga aacgccggct gtttctgtgt 2415721 gtccaactgt aatgctttca atgttgtaat gcctttttgt gaatagaccg gtgatccggt 2415781 ttaacacccc ggagcggttc accacagtca atgtgataat tcttttcaag gtttcacccc 2415841 caccatttca tgcagccctt tccccggagc caccatcggg aatacttttt cttcgctggc 2415901 aacccgcacg tcaatgacaa caggttctct tgatgttaat gcctcttcca gcttttcctt 2415961 tgcttccgct tctgatgaaa ttctgatgcc tttaatgccg tatgcttcgg acaatttgac 2416021 gaagtcaggc tgagaagcga atttagattc tgaataacgt tcttcataga aaatttcctg 2416081 ccactgtctg accattccga gacaagcgtt atttaaaatc actaccttga ccggaagatt 2416141 taattcgcga ataacatcga gttcttgaag cgtcatttgg aatccgccgt ctccgacaac 2416201 cgcgacaaca gtagcatctt tttcggccag ctgtgcgccg atcgccgccg gaagaccgaa 2416261 tcccatcgtt ccaagtccgc ctgacgtgac ccatttatct gctttttgga acggataaaa 2416321 ttgcgctgac cacatttgat gctggcctac atccgttgcg acaatggcct ctccttttgt 2416381 aaattgatga atatattcaa tcaatttctg aggtttaaaa ccttcttctt cattatctac 2416441 ataccagagc ggatactctt ctttccattc tgcgagctgt tttttccatt cgcttgaatc 2416501 gctttgtttg ccgtcttgtt tgatcagctc ctgcaggaca attttgctgt ctccgactac 2416561 aggaatctgt gttttcatga tttttccgat ttcagctgga tcaatatcga tgtgggctat 2416621 ctttgcgttt ctggcaaagt gtttcaggtt tcctgtgaca cggtcatcaa aacgggcgcc 2416681 gatactgatt aatagatcac attcatgaag ggccatattg gctgtataag taccgtgcat 2416741 tcccgccatc cctaggaaaa gcggatggtc agccgggaag cctccgagcc ccaaaagggt 2416801 gtgtgccaca gggatttgct gctgttcagc ataatttttt aattcttctg acgcttttcc 2416861 gtgcagtacg cccgcacccg ccaggatcac cggttttttc gcactgctca cggcttccac 2416921 aagcttgcgg atctgcaaat aattcggctc tgttgtcggc tggtatcccg ggagattcat 2416981 ctcatgatcg tagctgaatt ctccttcaat tgttgctaca tctttcggaa tatcaatcaa 2417041 tacaggtccg ggtcttccag ttgttgcaat atggaacgct tctttaatga tgcgcggcag 2417101 atcttccggc tggcgaacct ggtagctgtg ttttgttact ggcatcgtaa tccctaaaat 2417161 gtctgcttcc tgaaatgcat cgctcccgat tacagaggtt gctacctgcc ctgtaaagac 2417221 gactaacggc aatgaatcaa tcatggcatc agcaaggcct gtaacaaggt ttgtcgctcc 2417281 cggccctgac gtggcaatga cgacacccgg ttttccggag acccttgcgt atccctccgc 2417341 tgcatgaatt gctccttgtt cgtgacgggg aaggatatgt accaaccctg aattgtatag 2417401 cttatcgtaa atcggaagca cagccccgcc cggataaccg aagatcattt ctactttctc 2417461 tttttttaat gattcaatca gcattaatgc tccgctcatc gtctgtgtac attcggcaga 2417521 tgctgaatcc acctgtacat tagtccccat tttagttcct ccttttggat tttcatcctt 2417581 taaagatcat cttttcatta gctagatagc tgattattca ataaaaaaag cccttccgcc 2417641 cacaatcagc cgcgcagtaa ctgcgatagc taaaaggggc gaaaaggctt ttctttccgc 2417701 ggtaccaccc ttgtttacgg cctgttaatc ggccgtctca tggatatttc tatccgcttt 2417761 agtaacgagt gaatcaagtt cacccggcca agtcctactg tcatttcaga ctggcactct 2417821 gaggcgagtt caccttgtaa agcttcgccg gttctcagct aacccggttc tctgtggaaa 2417881 actttatcaa ggctacttat cctcatctgc gcttttcata ttcagccttc ggaacggctt 2417941 tccagctgtt caagaaggtc gtttgttttt cattttttta gaatcatact gcgatgattt 2418001 tcgcttgtga agcttgcatt tatcttttgt tgaactcata ttacgccgct ttggacgcag 2418061 tgtcaacagc attttttaaa attattagac aattttgatt aatcaatcta tattgtatac 2418121 gctttcatta ttggtacaaa aggaattgca aatgttaaaa gtttttataa tttttttatt 2418181 aatctatcaa gaatacacca gaattattta attttatata aacatggaag attttataac 2418241 acgatatggt tcgtatatgg attgagtctg acagatcatc ttgcaatcca tttcaatttc 2418301 ggataggcac ttctcttgtt ccctcggcat acattaatga tatcttgcaa agaaaaggtg 2418361 atacgatgaa taaatcattt gcagacatgc aaggatttcc tgcgggcttt ccaagcttcc 2418421 ccaactttcc gcagcagtac tatcctgctg tccctccctt ttaccagcaa agccagcagc 2418481 catttggagg ctacggatac ggacagccgt tcagtcaggc atacagcccg ttaaccactc 2418541 cctctggaat gtactcctca ttcccatacg cttcaggatt ttacggacag caattttcag 2418601 gtgcaggctt tagcggccat ggcggcagct taagtgctcc agcgatacat gccggcggat 2418661 tcagcggggc gccaggcgta cacggaggct ttagatatta aagaatacca caagggccga 2418721 acatctattg cggtcctttt attgttttaa aacgacttca caagtacagt cacattttct 2418781 gtctttatat ttggaaacag gatggaatat gattaagatg aattgaacga tattctgcac 2418841 aatccgtaag ttttcgagga ggaataaaat tgcatataaa aatagacgat ttaactggac 2418901 gtcaggtggt ttcactggtg aatgagcatt tacatagcat gacgcttatg tccccgccag 2418961 aaagcattca tgccttaggt ctagaaaaac taagagggcc tgaaataaca ttttggagcg 2419021 catgggaagg tgatgaacta gctggctgcg gagcgctaaa agaactggac acccggcatg 2419081 gagaaatcaa atcaatgcga acatctgcat cacatttaag aaaaggcgtt gccaaacaag 2419141 ttctccagca catcattgaa gaagccgaga agcgaggcta tgagcggtta agcttagaaa 2419201 cgggttcaat ggcttcattt gagccggcaa gaaaattgta tgaaagcttc ggtttccagt 2419261 attgtgaacc gtttgcagac tacggtgaag atccaaacag tgtgtttatg acgaagaaat 2419321 tgtgagacgg ctttataagg atagataagt gcaggggaag gtctgtctta tctatctttt 2419381 tttatattca cacatttttc acctttatga tacacgccaa tgttttcaat tttgtttaat 2419441 tcaaagaaca gcgggaatta caaacgacat gaacgatatc atgcaaattc ataaaggagg 2419501 agattgatat gaaaagcata gttggtgtat atgaaactcc gcaggaaacc atcgcagcga 2419561 ttgaaggctt acttacaaaa ggctatgatt ctgatgacat ttctgttgtg acaagccggc 2419621 gagatacaga ttatttggag tcacgtacag gaacagaagt caatcaagct atcgatgcac 2419681 atcaggacga atctgaatct tttttcgata aactgaaaga ttatttcaca atggatgata 2419741 ctgctacaca cagcaaagca ttatccgact tggatattaa aactgatgaa atagacaagt 2419801 atcaagaaga tttggatgac ggaaaacttc tggtagccgt cgatacagat gcagatgtaa 2419861 ttgctcctat tgataacggc aatgcccttt caggcggctt ttcaagcaca aatgaattgg 2419921 attatacaac gaaagaagaa aaaacgatgc cgctccggga agaacagctg aaggtcgata 2419981 aggaagacgt tcaaaccggc gaagtagaaa taggaaaaga agtgaaaaca gaaaaaagag 2420041 atatggacat tccggtgaga catgatgaaa tttatgtcga acgccgtcca gtggatgaaa 2420101 ataaaacgga cgctgctccc gtcaacgatt cggaagagat cagagttcca atcgttgagg 2420161 aaaagctgga agtgactaaa aaaccggttg tcactgatga agtggttgtc ggcaaacgca 2420221 ctgttgaaga aaatgaacat atttctgaaa ctgtgaaaaa agaagaacct cgtctgaata 2420281 aagaaggaaa agttgacggc ttggatgatg atccgttaaa taacaaatga aaatcataga 2420341 ccgacaacaa aaaacctcaa atcctaaatg gatttgaggt ttttcttttg gtacgtccca 2420401 ggagagattc gaactcccga ccgacggctt agaaggccgt tgctctatcc agctgagcta 2420461 ctgggacacg ttttgttttt ttgtttttcg ctttaactat cagcgacaag atttattata 2420521 tatgggatgc aataataagt caacggtttt ttagaatttt tttcatgagg aagaaaattt 2420581 tcttcctcat gacattttca tagtgtgact cgattttgca gatcctcaat ttcattgcct 2420641 gcttggtcgt aaaaacggac tgtcgcagca tcattttcta atgtcagtat agcatagctt 2420701 tctgtcctgc gcaccctcgg aagccggatg ctgcctgggt taatcatcag ttttccgcgc 2420761 agcacttcgc ttcccgcgat gtgcgaatgc ccgaagcaga taacatccgc cccgagctcc 2420821 tctgcacgat agtatacgtt taacaaggtc tgttttatac cgtgaaggtg gccgtgtgtg 2420881 actagtattt ttcttgagcc ggcagtcaga agaagctcgt ccttaaaatc gccggcaaaa 2420941 tcgcaattgc cttttacaac cgcataaggc tccaatgcag gatgcctcgt ctcaagctca 2421001 gagtccccgc aatgaatcat gagatcaact tctgcctcat gccgtttcgc aatggtttgg 2421061 agttcttctt caagcccatg gctgtcactg ataatcagca cgttcatgta caagcttcct 2421121 ccttatgcct ccaaaagctt agacagcttt ttaagcgcgt cagccctatg gctgatttta 2421181 tttttttcat cacttgtcag ttcagccatc gtcttatctt tatctttcac gataaaaatt 2421241 gggtcatagc caaagccata ttctcctctc ggttcttcag caatataccc ttcaacatgg 2421301 ccttcgactg tttttgtttc ctctccggga atactcacgg ccagtgcgca gcggaaacgg 2421361 gcggtgcgct gttctttttc gatacctttc agctcgctga gcactttttc gatatttgcc 2421421 tggtcgtctt tctgttcccc tgcatagcgg gctgaataaa ccccgggtct gccgccaaga 2421481 ttatcgatgg atagtccgga gtcatccgca atcaccattt tgttcactgc tttggcaaca 2421541 gcttccgctt tcataatggc attttcttca aatgtatggc ctgtttcttc aatttcctct 2421601 gtgaatccaa tttcagctaa agatttgaca tcatagcctc ttggctcaag aatttctttg 2421661 aattccttca cttttcccgg attatgtgtt gcaataattg cttctttcat gatgatcaag 2421721 cctttctgtc tttatttcag ttctggcaga gaatcaccca gcacttcttt ttgcttgtca 2421781 atcagctctt ggattccttt ttccgcaaga cccagaagac cgttcagatc ctctctagaa 2421841 aaagttgcct cttccccggt tccctgcaat tccacaaaac ggccgctgcc tgtcatgatg 2421901 acattcatgt caacttcagc agaggaatct tcttcataat ttaaatctaa caaaattccc 2421961 tgttccttat caattccaac agagattgca gcaagaaaat cagtgatcgg atttgtcttg 2422021 attgttcctg ctttgatcag cttgccaatc gcaatcgcca tagcaagaaa tgcgcctgta 2422081 atggaagctg ttctagttcc tccatcagct tgaatgacat cacagtcaat ccaaatcgtc 2422141 cgttcaccga gcttttccag atctacaaca gctcgaagcg cgcggccgat caggcgttgg 2422201 atctccattg ttctgccgga aattttcccc ttagaagatt ctctgattgt tctttggttt 2422261 gttgcccgcg gcagcatgct gtactctgct gtaatccagc ctttccctcc gccccgcaaa 2422321 aacggcggta cgcggtcctc aacagacgcg ttgcagatta cctttgtatt tcccgctgtt 2422381 attagaacag aaccttccgg atggctgata aaatccaaat cgaatgtgat tggacgcagc 2422441 tcatcgtgtt gtcttccgtc atgtctcatg ttttacctcc gattgtatgt acataaacca 2422501 tttttgtccc ggaattgaat aaagaaagag gcagccggaa cgctaacctc tttcttccta 2422561 gtatatcaaa aatcccaatt taaaaactac ccgtattcac ttgagatggt ctggagaccg 2422621 gttctgtgag cttttcgcct ttttcattta ccagctctga ttttccgttc actttaacag 2422681 agacgctttt tacatccggc tgctccgtta acgtcagcac aatgctgttc agcacttctg 2422741 aagaaatcat tttcgtcttc tcatcggcgc tgccgaatat agattgattg aaatccaacg 2422801 tcacgcgccc gtctttgatt ttcggtttgc tgaccagctt tacatcttca ctgaagtctg 2422861 ttaacagccc gctcaccttg ctcggccctt tagccaattc attaatggct gctgtgatgt 2422921 cgtctttttc cgaattgtcg attcgtttgg tcaccggcac gtagtattca ctgtcttcat 2422981 tttccgccaa atagtagact gtcagcggat gggtagcagt gagatcattt acaccggctg 2423041 tttccaaatt aatgccgtct ttgcggctta aatcatctga gatcggcgtc cctcctacag 2423101 gcatctcctt cagttcatgc ccgtttattc tcagcttcac tttatctatc gaactaaatt 2423161 gcgtcagcgt ccacgtcaca gattgaacga ttttctgttc gtcttctttc ttataatttt 2423221 tgaactcatt agagaaatca gctatcgccg ttccatcttt tttgatgtca acgttaacgg 2423281 tggtgtcagc cggcaataca gctctgaagc cattcggaag aatttcagac acaggcccgc 2423341 cctgtacgag gtattcaagc gcctgcttag ccgtgctctc acttttagga agaggcagcg 2423401 tttgcgcaac aacatacccg tttttatcaa tgagataaag ctccctcata acagtagatg 2423461 aggcttgatc cgcttttgcg gtatcgcttt tttcactttc tgtttttttg gctgctgttg 2423521 tatttgaatt ggcacccgct tcatcgttca cgaatgtaac gtcttgaggc ggatcaattt 2423581 cctcggctgc cttatcagat tgaaacaaac cgcatccgga taaaagcaag gcagaggtga 2423641 gacaagtggc accaatgact gcaggtcctt ttttcagcat acttttccct cctaaggatg 2423701 tttgtactat tatgtatacg agcctcttta ggaaatagac cgaagaattc cggcaaaaca 2423761 gaaaaaaacc cgcaacatac cgttgcgggg aaaactatct tttaatcggt tcttgcagtg 2423821 agatacattc cacatgcccg acttcatggc caaaccaatc gtctgcgatt tttgcaaact 2423881 gatcacgcgc ccctgttgtc aggaactgat gatccggggc aatcggagac tggttcagca 2423941 gccctttata agagagaatt gtgctgactt cccgggctgt ttcatcgccg gacgaaataa 2424001 tgtttacgtg ctctcccata tatctttgaa tggcttcttt taaaataggg taatgggtgc 2424061 agcctaaaat cagcgaatca attgatgtgt cttttaacgg atacagcgag gttttaacaa 2424121 tctcgtctgc tgttttgtcg agaaacttcc cgctttccac aaaaggcaca agcagcgggc 2424181 aggcaaggtt ttcaaccttc aaatcagggt ttaatgccaa aagcgcttct tcgtatgcat 2424241 tgctcttaat cgtattctct gtgccgatga caccgatatg ctgattatcc gtcactttta 2424301 tcgctgctct cgcaccaggc tggatgactc cgaccaccgg tataccgacg ctgcgctgga 2424361 tgtcatccaa agcgatcgct gttgctgtat tacaggcgat cacgagcatt ttgatgtggt 2424421 ggttttcgag taaataattc gtcagctccc acgtatattg aagcacctct tcttcagggc 2424481 gcggcccgta aggacaccgt ttcgtatccc cgacgtagat aatattttct ttaggtagct 2424541 gtctcatgat ttccttcgca acggttaaac cgccaacccc ggaatcaatg actcctattg 2424601 gttgttccaa caaaatcgcc tcattttctc ttcatttcat gctgcagttt catcaaagat 2424661 ttttcgaaga tggctatttc ttcatctgta aacgattcga acatatcacg cagatattcc 2424721 tgtctttttg taatgacctc ttggataatc cgttctcctt caggcagcag atgtatcctg 2424781 acaacacgtc tgtccgccgg gtccttgacc cgctcaacaa gctcattttt ttgcatgcgg 2424841 tcgattaagt ccgttgtcgt gctgcatgcc agatacattt tgcccgataa ttcaccgatt 2424901 gtcatatctc ctaattcata aagccattgc aagccgacaa attgcggcgg cgtaatcgca 2424961 tattggttaa ggatttctcg tcctttttgc ttaatgatcg cggcaatgtg gcggagtgac 2425021 ttttcaatat ccgcaacatg ctccaaaggt tttgatgtca tttgtccatc cctcactcaa 2425081 ggatctctta cgcacaaaag cgttccgtgt ctattttcct tcttttttga agaaaatgca 2425141 agactcgcag gagagaaata gaggacttta gtcaaacaac atcaagaaat aaaatttaat 2425201 ttatgacttg cctacgtttt gcacagcatt ccaaatatgg tttcgaatgt tccaaacaaa 2425261 cagcaataac cggctccttc caaaagaagg aataccggca aggattaaag ctctagctca 2425321 cccattctaa gaagctcaac aacggcttgc gaacgccctt tcacacccaa tttctgcatg 2425381 gcatttgaaa tatggtttcg aacggttttc tcactgataa atagctcgct tgcaatctcc 2425441 tttgttgtct tatcttgaac gagcaattcg aacacttctc tttctctttt cgttagcagc 2425501 ggcttcgatt gaaattcttt ctccttcaag tattgtaacc ctccttgcta aggtgagagc 2425561 gaatcagaaa cgaatgggtt ttgatatagt cgagatatca tatgtaagaa gggcgcagga 2425621 ggtgacgttt acaagataat tagtttatcg tgtatgaaga agcgtttctt tctcctcatc 2425681 cgtccagctg acagccttgc cgctttcctt tgagacttga accatcacga ctgccccggt 2425741 gaagcagggt tcgccttcga ggttctctcc gagatagtgc aaggtaagag atgaactgcc 2425801 gactgcgctt gttttcacat agatgcgcaa ctcttcataa ggcatgactt ggcgcaaata 2425861 atcgcattgc tggcttgcca cgactgtcat ggtctgtttg ttttcactca tcatattcag 2425921 ctttttaaaa taagaaatcc gcacctcctc aaaatatata aaaggggtta cattattcat 2425981 atgcccaaac atgtctgtct cggaaaatct tacggatacc ttattgaaaa aagaaaagga 2426041 tgttttccat tcttgaaacg gcatatcaat ataagcggga agcttcatct tttttcatct 2426101 ccttattgtt taaaaaaacc tctcccatgc ggaagaggtt ttttcttctt atactctgtc 2426161 gcttccgaag aaattgcgga acgcttgtaa gtttgtatct ctattcaagg ctgcaatcga 2426221 agtggtaagc ggaatcccct tcggacagga ttgaacacag ttttgcgagt tgccgcaatc 2426281 tgcaaggccg ccttcatcca ttaatgcttc taatcgttca gatttattca tggcgcctgt 2426341 cggatgcgcg ttaaacaggc ggacttgcga catcggtgca ggccccatga acttcgattt 2426401 gctgttcaca ttcgggcaag cttcgaggca gacgccgcat gtcatgcatt ttgataattc 2426461 atatgcccat tgacgacgtt tttccggcat tctcggcccc ggtcctaaat cgtacgtacc 2426521 gtcaatcggt atccacgctt ttactttttt caatgaatca aacattctgc tgcgatcaac 2426581 ctgcaaatca cgaacgactg ggaatgtttt cattggtttt aaacggattg gctgttcaag 2426641 ctggtcaata agcgccgtac aagactggcg gggttttccg tttataacca ttgaacatgc 2426701 gccgcatact tcctcaagac agttcatatc ccatgtgaca ggggttgtct tctcaccttt 2426761 gacattaacc ggattccggc ggatttccat cagagcggaa atgacgttca gattcgggcg 2426821 gtatggaatc tcaaattctt catcataagg cgtgctgtca gctgtatctt gacgtgtgat 2426881 aataaatcgt atggtttttt gttcactcat gattatttcg ccaccttctt cttcgagtaa 2426941 tcccgtttcc gaggcgttat cagtgataca tcgacatcct gatactcaaa ttccggcgct 2427001 tcatacgggc ttacatgttt agccattgtt gttttgagcc attcatcatc attacgttca 2427061 ggataatccg gtttataatg ggcgccccgg ctttcattac ggttgtatgc gccaagggta 2427121 atcaccctcg caagctgaag catgttcgag aactggcgtg tgaacatcgc tccctggttg 2427181 ctccattttg tcgtgtcatt gatgttgatc tttttgaagc gctccattaa ctcctgaatt 2427241 ttgtcatccg ttttcaaaag cttgtcatta tggcggacaa ccgttacgtt cgccgtcatc 2427301 cactcaccga gctctttgtg aagaacatag gcattttcgg ttccgtccat actcataata 2427361 tcagcccatt tttcttcttc tttcttaacg tgagcgtcga ataaagatga agacatgtct 2427421 tccgctgaag attctaagcc gtttacatat ttcaccgcat tcggaccggc caccatgcct 2427481 ccgtaaatcg cagacagcag ggagttcgct cccaagcggt tgccgccgtg catagaataa 2427541 tcacattccc cagccgcaaa cagtccaggg atatttgtca tttgatcgta atccacccat 2427601 aaaccgccca tagaataatg gaccgccggg aagattttca ttggaagctt acgcgggtcg 2427661 tctcccatga atttctcata aatctcaatg atgccgccaa gcttaatatc aagctctttc 2427721 ggatctttat gagacagatc gagatatacc atgttttcac cgttaatacc gagcttctgg 2427781 ttcacacaca catcaaatat ttcgcgtgtc gcaatatcac gcggcaccag gtttccgtat 2427841 gccggatatt tttcctccag gaaataccat ggtttgccgt ctttatatgt ccacacgcgc 2427901 ccgccttcac cacgcgctga ttcactcatc agtcttagtt tgtcatcgcc cggtatggct 2427961 gtcgggtgga tttgaatgaa ttctccgttt gcataatacg ctccctgctg ataaacgatt 2428021 gacgcagcag atcctgtatt aatcatggag ttcgttgatt ttccaaagat gattcccggt 2428081 ccgcccgtcg ccataatgac agcgtctgaa cggaaggatt caatttgcat gtttgtcagg 2428141 ttttgtgcaa caattccgcg gcaggttctg tcatcatcta aaacagcgcc aaggaattcc 2428201 cagccttcgt attttgtgac cagacccgca acttcgtatc tgcgcacttg ctcgtccagt 2428261 gcgtaaagca gctgctgtcc cgtcgtcgca ccagcataag cagttctgtg gtgctgtgta 2428321 cccccgaatc ggcggaaatc aagcaggcct tcaggcgtcc ggttaaacat gacgcccatc 2428381 cggtctaata agtggatgat cgaaggcgcc gcttcacaca tcgccttgac cggcggctgg 2428441 ttggcaagaa agtctccccc gtataccgtg tcatcaaaat gttcccacgg agagtcacct 2428501 tccccttttg tattgaccgc tccgtttatg ccgccttgcg cacaaactga atgagaacgt 2428561 ttgacaggaa cgatggaaaa caatttaacc gccattcctg attccgctgc tttaattgtc 2428621 gccatgaggc cggcaagacc cccgccgact acgataatgc ttgattgact catgatagcc 2428681 cctctccctc tagtaatcta gtactcttaa acaaatgcaa aaatcgcttt taagcctacg 2428741 tatgacagtg caacaaaaat aatcagcgta acgtatgtcg aaattctttg agaacgaggc 2428801 gttaccgtga tgccccatgt aacagcgaaa gaccataaac cgttcgagaa gtggaaaatt 2428861 gttgataaaa caccgacaat gtaaaaacca agcatagccg gagagctcaa aatattcgcc 2428921 atcatgtcga aattgacctc agcacccatt tgtgcggcaa tgcgggtttc ccacacgtgc 2428981 cagctgacga aaatgagggt gatgataccg gttacacgct gcaggacgaa tagccagttt 2429041 ctcatgtagc tgtattgacc ggcgttattt ttcgcagtaa acgctatgta cacaccataa 2429101 actgcatgat aaattaatgg taagaagata ataaaaattt ccaaggcata cctgaaaggc 2429161 aggctatcca taaaatgagc agcgctattg aatgcttcag cgccccttgc ggcaaactgg 2429221 ttgacgacta aatgctgaat aagaaagatg ccgaccggta tgacgccaag caaggaatgc 2429281 aatcttcgaa aataaaactc tctgttccca gacattactt taccccctgt ttgataagtg 2429341 cgaaatgtgc taaatctctt cccccacttc tttcaattgt aagcacttta ttaagattta 2429401 ttgacaattt cattttactc ctccctcaaa agggcgtcaa gaaaacgcgt acataaatta 2429461 taattttccg aattgattag ttgattgaaa aattttattt tatcaatata tatttcttgc 2429521 ttaatttttc ataagaatta caggatcatt ctgtaatcct cccccctgtt tgagctataa 2429581 tatacgcagg agagagggga gacagatatg aagtctaaat ttgaagcatc tattgacaac 2429641 ctaaaagaaa ttgaaatgaa cgcttatgcc tacgaactaa tacgagagat cgttctccca 2429701 gatatgcttg gccaagatta ctcttccatg atgtattggg caggaaaaca tctcgcccgt 2429761 aagtttcctc ttgaatcatg ggaggaattt ccggccttct ttgaagaagc gggctgggga 2429821 accctcacca acgtaagcgc taaaaaacag gagcttgaat ttgaacttga agggccgatc 2429881 atttccaacc ggcttaagca tcagaaagaa ccttgctttc agctggaggc tggttttatc 2429941 gctgaacaaa ttcaattgat gaatgatcag attgccgaat catatgaaca agtgaaaaag 2430001 agagccgata aagtggttct gactgtgaaa tgggatatga aagacccagt gtaatcaaaa 2430061 aggcggtgac tgcatagtcc cgcctttttg attgtcatta cacagctgaa gggtgttttg 2430121 aaagctcaaa tgcatcgtga agcgactcga ctgctttcac catgtcattt tcgcttacga 2430181 ctgttgacac tttgatttca gatgtgctga ccattttgat taaaatgttt ttttgcgcca 2430241 gtacagcaaa catttcagcc gctacaccgg gatttgagac catgccggat ccaacaatag 2430301 atactttagc caatttgctt tctgtctcga ttttctcaaa ttccagcgcg tctttatact 2430361 cttcaagcac cgcaacggtt tggtctgcat cttctgtttt gacagagaag gaaattccag 2430421 tcttgtcctc ggcctgcgtt tggataatga tatccacgtt tatgtttctt ttggcaagtg 2430481 ttgtaaaaat agtagacaaa gttgtcaggc cgctagtcag cccgtaaatg gttactcttg 2430541 tgatttgatc ttcaaatgca atgcctctga caattaaatt ctgttccatg gatgattcct 2430601 cctcaattaa tgttcccgct tcggtttctg tacttgaacg cacttctaac ggcacttggt 2430661 aatttttcgc gaactcaact gctctcggat gaagaacacc ggcgcctaaa ttggcaagct 2430721 caagcatttc atcgtatgag atgccctcaa gttttctcgc tgatttcaca tagcgcggat 2430781 cggttgtaaa cacgcctggc acgtctgtgt atatgtcaca tttatcagct tttaaagcgg 2430841 cagccaaagc aactgctgtt gtatctgaac cgccccggcc caatgtcgta atttcacaat 2430901 cctctgtcat gccttggaat cctgcaacaa tgacaatttt tcctttttca agctggtctg 2430961 ctaaaaccga agtgtcgata tctgtaattc tggcgtttcc gtgaatggcc tccgtacgga 2431021 ttcccgcctg ccagccagta taagacacag cgtcatagcc tttttcctgc aatgccattg 2431081 aaaggagtga aatcgtgacc tgctcgcctg tcgccagcag catatccatt tcgcgtttgc 2431141 tcggctggtc agaaatagct tttgcaaggc tgaccaattc gtcagtggat tttcccattg 2431201 ctgaaacgac gacaacgact tgatggcctt tctgtttttc tgcaattgcg cggtttgccg 2431261 cattttgaat tttttcgact gagccgacgg aagtgcctcc gaatttttgt acaataagac 2431321 ccatgtatta ccacccttta cattttggtt cgtgcgggtg aggagaaaga gcgctttgtc 2431381 cacaataaaa aaagcaatga gaggaatact ctcattgctt atcaattaat catcataaat 2431441 gattatgaac aacgagatag ccctccaaga aaatgatttc ttgacagcct tacatttatt 2431501 caatgcacgg ccagcaaata ataccgatgg ggttttattt gcttcggcga cgctcccctt 2431561 tcagcctttt tcacagaatc catctttctc caaaggcata ctcttgaagt tcgcacctct 2431621 atcttcacca tataacacga tctaactatg aaattagttc acattttatc agatcttatt 2431681 taaaaggaca acattatttt tgcaatttgt cgtaaaggag ctgagccgcc gctgcgggaa 2431741 caccggcttt tttgatgtcc tcaaggcttg cttccttcat ttttttaacg gaaccgaaat 2431801 gctttaacag cattttcttt cttttctctc cgatacccgg gatgtcgtcc aaaacggatt 2431861 gaaacgcgct ttttccccgg atttgcctgt gaaaactgat tgcaaaacgg tgcacctcgt 2431921 cctgaatgcg ctgcaggagg taaaattcct ggctgtttcg ttccagatac gccacctcca 2431981 gcggatcacc gatcagtaaa tttgaggttc tgtgtttttc atctttcgct aaaccggcga 2432041 tcgggatatc caagccgagt tcattttcaa tgacatccct tgctgcgttg atctgccctt 2432101 ttcctccgtc aatgataatc agatcgggca gcggcagatt ctcacgaagc actctcgtat 2432161 agcgtcttct gacaacctct ctcatagaac cgtaatcatc cggccctgta acagttttga 2432221 ttttatattt gcggtattcc tttttgtatg gtttgccatc gataaacaca atcatcgcgg 2432281 aaaccgggtt tgtcccctgt atatttgagt tatcaaacgc ttcaattctg tgcggcgtat 2432341 aaatatttaa tgcctcacct agtttctgca ctgccccgat tgaacgctcc tcgtcccgtt 2432401 cgattaaaga gaatttttct ttcaatgcga ttttcgcatt tttatgggca agcatgagca 2432461 gttctttttt cgggcctttt ttcggctggt gaacgtttgt ttccagtagc tgctcgatca 2432521 tagattgatc tatgctgtcc ggaactaaaa tctccttcgg aaggaagtgg ttgttttttg 2432581 aatagaactg cccgatgaac gtgaggaact cttcatctgc ttcctgataa agcgggaaca 2432641 tgctgacatc gcgttcaatg agctttcctt ggcggatgaa aaagacctgc acgcacatcc 2432701 agcccttatc gtacgcgtac gcgaacacat cacggtcgac tagatcgttc atcgtcattt 2432761 tttgtttttc catcgttgat tcaatatggg caatttggtc acgaagctct tttgctcgtt 2432821 caaactcaag attctcagca gcttcatgca ttttctcttc aagctctttt ttgacctcat 2432881 tatagccgcc ccttaagaaa cgtgtaatgc tttcaaccag ctctctgttc gtctcttcgg 2432941 aaatatcctt tacacacgga gcaaggcatt ggcccagatg atagtaaagg cacactctgt 2433001 ccgggagctt ggagcatttt ctgagaggat acagacggtc gagcagtttt tttgtttccc 2433061 ttgctgcctg tacattcgga tacggcccga aatagcgccc tttgtctttt ttgacattgc 2433121 gggtgacaat cagccttggg tggcgttcat gggtgagttt tatgaaagga taggttttgt 2433181 cgtctttgag catgacgttg tatttcggat catgcttttt gatcagattc atttctaaaa 2433241 taagcgcttc aagattggag gacgtcacaa tatattcaaa atcctcgatt tccgtcacaa 2433301 gcctttgggt tttcgcgtcg tgagaaccgg tgaagtagga gcgcactctg tttttcagca 2433361 cttttgcttt ccctacgtag atcacagtct gctgccggtc cttcatgaga taacaacccg 2433421 gttgatcagg aaggagggcg agtttttctt tcagttgttt gttcatatgt tacccttcct 2433481 tatgtttaat cctttatttc cagtttaaca cgaacgtttg tttttctcta tggttcacaa 2433541 ttggcgaata aaaaaagcga tccctcaatc ggaatcgctc tggcatgtaa gcagcggaaa 2433601 attaaagatg tttgtttaca agctcttgaa gcgcttcttt tggtttgaag ccgactgaag 2433661 tttcaactac ttcgccgtct tttaacacaa gaagagtcgg gatgctcata acgccgtatt 2433721 ttccggcagt ttcttggttt tcgtctacat cgatttttac gattttcagt ttgtctccca 2433781 tttcttgatc caattcttca agaacaggtg caatcatttt acaaggtccg caccaaggag 2433841 cccagaagtc tgccagtacg acgccttcgc ttgtttcagc tgagaaagat tgatcagttg 2433901 cttttacgat agccattatt gaattcctcc aatgtgaaat gatgattttt agtatagcat 2433961 ctcccattcg ttcacgctat tttaatgctt acaaattatt ttttcctgat cacagccggt 2434021 ttactcattt ttatatggtt gaatgggata tgctcttttt ttaaaacaca aatctgataa 2434081 tggccccgat cactacaatt gccccaataa tcattaaaat ggtacgaagc ataagatcac 2434141 atctcctctt cactgtcatg tactttacca tgccctgccg gagctgtttt aaaacctgaa 2434201 aaagagcgcc ggcatgaagc tccggcgctc ttgcgcgatt aagaatcagc acgcagcgta 2434261 agtaagacga ctgacattgg cgggagtttt actttcagtt tgtttttgct gagcgtgtat 2434321 tgtctgaagg attccggttt gacatgatga ggatcgtcaa acgtgttatg cgcattcatt 2434381 ttttctgccg taagaatgac tccggaatgg tccgctgcct tgtgtaggcc cctcagctcg 2434441 atttccgcct ctgctttgtt ttggtgatcg atgttgcaaa ttgtgatatt gatatcgcct 2434501 tcagcttgtt tcgacgctga aatgctgatt tgcggaagcg tttcaccgtt ccattcatag 2434561 tcggcagaca ttgtctctgt ggctaaaaga gaagcgtcct ggtgcacctt aaacatattg 2434621 aatacatggt acgtcggtgt caaaagcatc cgctctccct cagtcaaaat catcgcttga 2434681 agaacattta ctgtttgggc gatgttggcc atttgcaccc ggcggcaatg ctgatggaaa 2434741 atgtggaaat gagaagccgc caccagtgca tcacgaatgg tgttttgctg atataagaaa 2434801 ccgggattcg tgcctggctc gggatcaaac cacgtgcccc attcatcaat aatcagcccg 2434861 acccgctgct ccggatcgta ccggtccata atcgtgccgt gtttttgaat caattcatcg 2434921 atgtatttgg cttttttcat cgtaataaac cattcatctt ccgtgaattc tgtggctgat 2434981 cctttgccct tccagaaatc ccccggaatc gtgtaataat gaagactcaa cccgtccatc 2435041 aggccagcgg cttttttcat aagcacgtcc gtccaattaa aatcatccac atttgcgccg 2435101 cctgcaattt tataaatgtc attcccgctg taattgcgga cataagtctg aaaacgccgg 2435161 tacagatctg cgtagtattc gggatgcatg ttgccgccgc agccccagtt ttcattgccc 2435221 acgccgaaat atttcagctt ccaaggctct tctcttccat tttgctttct ccagtctgac 2435281 atcggcgtgc cttcttcaaa tgtcatatac tcaatccact ccgacatttc ctgaacggtt 2435341 ccgcttccga cattgccgca aatatatggc tcgcattcaa gcagctcgca aagcatcata 2435401 aattcatgcg ttccgaattc atttgattca attgtaccgc cccagtgagt gttcagcatt 2435461 gtcttacggt caccgacacc gtttgcccaa tggtattcgt ccgcaaaaca cccgcccggc 2435521 cacctaagga caggaatgtg cagctgtttg agcgcctcca gcacgtcctt tcgtatcccg 2435581 ttgatattgg ggatgtctga gtccgttccg acccagatcc cctcataaat ccctcttcct 2435641 aaatgctcag caaaatgacc gtatatattt ttgttaatgg ttccttttgc gatatctgtt 2435701 tgaatcactg cttgatgttc agacatgcct ctgatcattc ctttcatacg gatatgaaaa 2435761 gcaccacagt caaatatgtg atctgtcgtt tgcctgagga gtcagcatga atgtaagcgc 2435821 ttttaaagta accatattat atatgttcgt acatgtcaac gacattttct attgttttta 2435881 tatttgtacg tatgtattta taaatatgaa aaaacccgga cttttaaagt ccgggatttc 2435941 ctttatgagt gtatattcag ctgtttgaat tcctcagtta ataacgggac aacttcaaat 2436001 aaatcaccga cgatgccgta atccgctatt ttaaagatat cggcttcggg gtctttattg 2436061 atggcgacga tcaccttgct gtttgacatg ccggccaaat gctggatggc gccggaaatg 2436121 ccgcatgcaa tgtacaaatc cggagtaacg actttcccgg tctgcccgat ttggagagca 2436181 taatcgcaat aatcagcgtc acatgccccg cgagaagccc cgactgcggc ccctagcacc 2436241 tctgcaagct cctgcagcgg ctgaaatcct tccttgcttt tgactcctcg gccgcccgca 2436301 acgataattt tcgcttcgga gagatcaaca ccgtccgccg tttttttcac gacctcttgg 2436361 ataacagtgc ggaggtcagt aagagaaaca tcaatgcttt cgatgctccc cgatctgctg 2436421 gtgtcttttt ctgaagcttg aatgttattg gggcgaattg ttgcaaagat catcggatcg 2436481 gttgaaatga cgcgttcaaa agctttcccc gagtaaatcg gccgtgtgaa cacaacattc 2436541 cctccggtaa cgcttacatc tatagcatca gaaattaagc ctgtttgcag acgggcagca 2436601 agcttcggtg aaagatcctt gcccattgcc gtatgcccga agatgactga atcaggattt 2436661 tcttgctcga taacacctct catgacctgg ctgtacccgt ctgccgtgta tgttttcagc 2436721 ttcgggtcct cagcggtaag aactttatct gctccgtaat gaataagctc ttgtgcaatg 2436781 ctttgtacat tttcaccgat gagaacaccg atgacttccc catctcctga aatggttctt 2436841 cctgcagcta ttgcttcaaa ggtgacattt cgcaattccc catcgcgtat ttctccaagc 2436901 acgatcactt tttttcccat tctaacatcc ccctgtttct ttgaatgtcc aagttttaaa 2436961 tgactttagc ttcgctgcgg agcaatgaaa caagctcttt tgcctgttca gcaggctcac 2437021 cttggagaag cttcccggct tcttttttcg gcggcagaaa acgttcaatg gttttcagct 2437081 ttggttcagc atcctcttcg tccagatcaa gatcatcaag ttcaagctct tcaagcggct 2437141 ttttcttagc cttcataatt cccggaagcg atggatagcg cggctcgttt aagccctgct 2437201 gagctgtgac aagcaatggg agcgtcgttt tgattttttc aacatcccct tcgacgtccc 2437261 tttctgcttc tgcatcagtg ccgttgattt cgagtttggt gatcgtagtg atacacggaa 2437321 tgtccagtag ctcggcaagc cgaggcgcca cttgtcctga tcctccgtca atggcaacat 2437381 ttccgccgag aatcaaatca aactcctgat ccttcatata gtggtataaa acttgagaaa 2437441 tggaatattg gtcgggttca tcaagatcat cttctatgtt gattaaaaca gcttggtcac 2437501 aacccatggc aagcgccgta cgcaattctt tctccgcttc ttcaccgccg accgtgacag 2437561 cggtgatcgt gccgccatgc ttttccttca gctggatggc ttcttctatc gcgtactcat 2437621 catatggatt aatgatccat tccgctccgt catcctgaat ctttcctgtt tcaatgacga 2437681 ttttttcttc tgtgtcaaac gtccgtttca tcagtacaaa tagattcatg atcatatccc 2437741 cttttattcg cctttgaact gaggctttct tttttcgaga aatgcctgga tgccttcctt 2437801 ggcgtcctct gactcaaatg cttccccaaa tcgctttgct tcaagcttta agctgccttc 2437861 ataggaatac accttgttgg aataaagaag ttcaagcaaa gatgccagcg tttgcgggct 2437921 tttctctgca aacttagcgg caagtgcttt tgctttttca atcacttctg cctcatcttt 2437981 cgctccaatt gagacaagtc cgagatcaag cgcttctttt ccggatatcg gttctcctga 2438041 tccgatgagc tccagtgctt tggctgtacc gacatatctc ggaaggcgct gtgtccccgc 2438101 aaaacctgga atgataccga gattaagctc cgggagcccc agcttagcat cttctgccgc 2438161 gattctgatg tgacaggcca ttgcaagctc cagcccgcct ccgagagcag cgccgtgaat 2438221 cgctgcgata atcggttttg gaaaactttc gattctctcc attaactgct ggccgcgctc 2438281 agcgagcaat gaggaatcct cattgccttt aagcgatgta aattctttaa tatcagcgcc 2438341 ggctgagaaa aatcttccct cgccgtgaat gataatgctt cgtacgcctg catctgtctc 2438401 acattgatca agacaggaag acagctcttc taatatccgg cttgaaagcg cgtttgccgg 2438461 cggattgtga atcgtcaaga ctgccacaaa ttgatcaacc gcaagtgaaa ttgcattcat 2438521 aggacagaac tcctttactt attgtgaatt ccggatacca ataattctaa aacgctgttt 2438581 gaaagcgcaa cgagatcgta cttttggtca ttcatcaccc aagttgtcac agtttcgtca 2438641 atcgttccaa aaatcatctg ccgggcgagg cggacatcga ggccttcttt tatttcgcct 2438701 gattgtatac cttccgtcaa aatgccatcc aaaatattta agtagccttt taatatttcg 2438761 ttgatttttt ggcgcagctc caagttggat tggcggagct caagctgcgt gacaatggcg 2438821 agattatggt cacccgctaa aagggaaaaa tgctttgaaa tcacaagcgc caatttctct 2438881 ttcgctgttg ctttttcttt aatgtcctct tccatccgct caataaattg acccattttt 2438941 tctttgaaaa gagaaattaa aatatcttct ttgtttttaa aatagagata gatggtgccg 2439001 tccgctaccc cggcttgttt ggcaattttg gatacctgtg actggtggta gccgttttct 2439061 gcaatgactt ctactgctgc atcaataatc tgcatatact ttggccgttt ttgcttcaat 2439121 gttcatcgtt ccttcctata gaaatgaatg actattcatt cataatttca tgataagaag 2439181 gattttcagg tttgtcaagt ttattcatag gcgttctctt tttttatttg atatgatgat 2439241 tttcggtttc ttcttcaagt aaacgccttc ttaaaatttt tcccaccgcc gttttcggca 2439301 gctcctttct gaactcatag gctttgggca ccttataggg agctagacgt gatctcgcaa 2439361 aagcgtccag ttcttctgta tcggcttttg cgcctttctt taatacgaca aatgctttta 2439421 ctgtttctcc cctgtaggaa tcgggaacgc ctgcgacaac aatttcctgg atggcttcat 2439481 gttcataaag cgcttcttct acctcacgcg ggtaaatatt gtaaccgccg gcaatgatga 2439541 tatccttctt cctgtcagca atatagaaaa agccttcttc atccatatag cccatgtccc 2439601 cggtgaacag ccagccatct ctcagcactg cggcggtttc ctctggttta ttccagtatc 2439661 ctttcatgac ttgcggacct tttacaatga tttctccatg ctcatacgga gcggcaagct 2439721 cacccgtctc ttcagaatag atcgcagcgt ccgtactcgg ccaaggacag ccgatactgc 2439781 ccggcttgtt ttttccccag ataaagttgg cgtgcgtcac tggggatgcc tcagacaaac 2439841 catagccttc cacaagcttt ccaccagtca ccttttcaaa tttctgcttt acctccacgg 2439901 ggagcgcggc tgatccgcta agacagcttt taatggatga cagatcataa tgctgcaatt 2439961 cagggtgatg caaaaggcca atgtaaattg tcggtgcgcc aggaaagagc gtcggtttgt 2440021 gtttgtcgat gattttaagt gtttcgagcg gatcaaactt aggaagaaga atcatttcga 2440081 agcctagttt aatcgaatag ttcatgactg ccgtcagtcc gtagacatga aaaaatggaa 2440141 cgatgcccag cactttttca gcgccttctt tcacgtcata catccaagcg gcgcacattt 2440201 cagtatttgc caaaatattt tggtgcgtga gcatgacccc ttttggagct ccggttgttc 2440261 ctccggtata ctggaggaca gcgatatcat gctcaggatc gatcttcggg attgtcagga 2440321 gttcagtttt ttcctgcttc atacaggaag cgaacgtgtg aatgttagct gttttgtcaa 2440381 agtcgatatg cactttttgt ttttgcgtca gcgggtaaag aatatttttc ggaaaaggca 2440441 aatagtcttt tacactggtt atcaaaatct ggtcgactat tgataacgtt ttcattttta 2440501 ttgccttcgg gaaaagcaaa tctaaggtga tgattacact tacctgagca tctctaagct 2440561 ggtattcaag ctcatgctcg gtataaagcg gattcgtctg caccacgatg ccaccggcaa 2440621 acaagacgcc ataataagaa atcactgttt gcgggcaatt gggcagcata acagccactc 2440681 tgtctccttt ttgcaggcca ttgcactgca aaaaagctgc aagtttaaga gcatccgtca 2440741 gaatgtcatg aaaggtgagt ttttttccat aaaacgatat tgcggtttta tcagggaatc 2440801 gtgcggcgga gtctgtcagg atggattgca gggttttatt cggcaacgga agctcatgcg 2440861 ggatatcgtt gggatactcg gcaagccacg gcttttgaga ctgcataaaa cctccccttt 2440921 cgattttaga gatccacctt atcattatag cagatggacg gcaaaaaaaa gaaaaagaaa 2440981 ggtaaatctt tctttttctc ataatatgaa cagatatata agaccaatta acaaaaagat 2441041 tcccgctgcg gcgagcagta ttttcgcaag cttttccatc tattctccgt ccccttatat 2441101 tccggctgcc accacaaaag aaagcccgac agaaatgaca aatgaaataa agccgacagc 2441161 ccggttatca ttttcgattt cctgatcaat tttaaaccgc ggagtcaaaa actcaaaaat 2441221 aaagtagctg atcagaagca taacaaaccc gtaaacgccc cagccgatca tttgcagcag 2441281 cgaattatgc tgggagatgg aatgctgaaa tacgtttgcg attcccaaaa tttttccgcc 2441341 ggtcgccatt gccaccgcaa gatttccttt ttgaatctct tcccagtttt tataagccgt 2441401 caccagctca aacacagtca aaaagaggac gaggcagaga accgcgacac tgtaatatgc 2441461 cgcgatttcc acaagctcgt tttcccaaaa atcactcatg gccatactcc cttttatttt 2441521 agttcaacaa ccgtaacgcc tgatcctccc tcacctgctt caccgaaacg ggaacttttg 2441581 acgctgcggt ggtttttcag aagatcctgt acgccttttc ttaaagcgcc ggttcctttt 2441641 ccgtggatga ttgacactct tggatatccg gctaacaccg catcatccaa gtatttttca 2441701 acccggctga gggcattttc atagcgttcg ccgcgaagat caagttcaag cgatacgtga 2441761 tagtcctttc ctttgaccgc tgtaatcatt ttttcttttt ttggctccgg agctgatttg 2441821 ataaactcca gatctttttc ttttactttc atctttaaaa taccgatttg aacgttccat 2441881 tcattgccgc ctgttttttc gagcaatgtt cctttttgcc cgaaagtgag gactttcacc 2441941 tcgtcgccag gcttaaagtc gcgtttttgc gttttcggct tttccggttt cttggacttt 2442001 tcaaaagcag gcatagcgcc ttctaaccgt ttcttcgcgt taatcagctc gtgatccttg 2442061 aaggatttgt gttcttcttt tatggtgcgc aattcatgaa taatgtcctc ggcttctttc 2442121 attgccgctt ttactttttc agcagcctgc tgttctgcct cttcaagcat tttgtctttt 2442181 ttgctgttaa gctcgatgat ttgctgctgc agctctttat gcagtttttc cgcttctttt 2442241 ctgattgatt ctgtctcaga aagctcttct tccgcacgtt ttttgctttg ttccagcgac 2442301 gcaatcatcg tatcgacttc gttatgctcg gccgtcattt ctgacttcgc ctgcccgatg 2442361 atatggtccg ggagcccgag gcgttttgaa atttcgaaag cattgcttcg acccggcaca 2442421 ccaattaaaa gtttataggt cggtgacagc gtttcgatgt caaattcaac gctggcattc 2442481 atgacgcctt ctctgttata gccgtacgcc ttcaattccg gataatgcgt cgtagctaac 2442541 actcgtgcat tggtgcgatg cacgtcatcc aagatgctca tggcgagggc cgccccctcc 2442601 tgcggatctg tccctgcacc aagttcatcg aaaagcacaa ggctgttttc attgacctgt 2442661 tctaaaatgc cgacaatatt caccatatgg gatgagaacg tacttaaact ttgctcaatc 2442721 gactgttcat caccgatatc agcgaatacg tgctcaaata ctgccgcttc tgacccttca 2442781 tctgccggga tatgaagacc tgactgcgcc attaaggtta gcaggcctaa cgttttaagg 2442841 gtgactgttt tccccccggt gtttggccct gtgatgacaa tggttgaaaa atcgcggcca 2442901 agctcgatgt cattggcaac aacctgatca ggcggaagca atggatggcg ggcttttttc 2442961 aaacggataa agccggtgtc gttcataatc ggttttgtcg ctttaaccgc ttttgcatat 2443021 ctagcttttg caaaaataaa gtcaagcgtc tgcagcactt gcaaatctag aaatagctcc 2443081 tctgtatact ctgccgtttt ctctgtcagc acacgcaaaa tccgttcaat ttcttgcttt 2443141 tctttcactt tcgcctgctg aagggaattg ttcatatcta caatcgcctg cggttcaatg 2443201 aatagtgtcg caccagagga tgaggtgtcg tgcacaattc ctccatagct ggatctgtac 2443261 tcctgtttga ccgggatcac aaagcggtca ttccgaatcg taacaatcgt atcagacagc 2443321 attttcgatg cggaagagga acgcagcatc gactctaacc ggtctctgac tcttgattcg 2443381 agtgttctga gctgtgtgcg gattcctctt aatgtttccg atgcatgatc aagcacttct 2443441 ccgtgatcat caatgcagga attaatgtcc cgctctaaat cggacagcgt gataagctgt 2443501 tcagcatgct gatggatcag cggaatgtcg acaccgtctt cagccatttg cgtgataaaa 2443561 tgtttcattt gtttaactgc ataaagcagg cctgagattt cagtgaattc agaaggactg 2443621 agaacgctgc cgatttccgc ccgtcttaac gctcctctga tatctacaag gccgccaaat 2443681 ggcgcttggc ctctcagccg gataatgtca gaagcttcgt ctacttcatc cagctgtttt 2443741 ttgatttcgt ctatagaagc agaaggctta agctcgagaa gcatttcttt tccgagcgat 2443801 gaagcggcat gcccaataac ctgttctttc actttatgaa attcaagagc tgataatact 2443861 ttttgctgca cgattgtgtg agcctcctta cttaatcgtt gcgcttcaga aatgcctcta 2443921 cgtctttaag cgaccgggca ttcagaacgt ttttcgtttc cgtccatcct ttgcgcgcgg 2443981 cagtaacgcc agttttcata tcgtctaaca tctcaatatt atgggcatca gtattaatca 2444041 ccaatgtaac cccttgttcg tttgctttca ttaaatgctc tgtgcgcaga tcaaggcgcg 2444101 cagggttggc attgagttca agcgccgtat ttgttttcct cgcaagctca atcagctgat 2444161 caatatcgat ttcgtaaccg gcccgtctgc cgataaggcg cccggtcggg tgtgcgataa 2444221 tgtcaacatg cttgtttgtc agtgccgtct caagccgttt cataatcacg tgttccggct 2444281 gattaaaact ggaatgaatc gatgcaataa cgatatccat ttccgcaagc acatcgtcat 2444341 cataatcgag cgtaccgtca ggcaggatat ccatctcaac gcctttcaaa atacggaagt 2444401 tttcaaactc tgcattcagc gcgtcaattt cttttgcctg ctgcttaagt ctttctgcag 2444461 taagcccgtt ggcgaccttt aaatattgtg agtgatcggt gatcgccatg tattgatagc 2444521 cttttttgat gcaggcttca gccatctctc tgatcgaaaa tgcgccatcg ctccacgttg 2444581 agtgcatgtg gagatcacct ttgatttgcc cgagctctat cagttcaatg ctgtcgctgt 2444641 aggtttccac ttcctgtccg ctttcacgaa tttccggcgg aatcagcggc aggccgaagt 2444701 gcgcataaaa ttcacgttca ctcggaaatg ttttgatctc tccggtttca actgtctcaa 2444761 cgccgtattc actgatccgc tcgccgcgtt ctttggcgat ttggcgcatc ttaatattgt 2444821 gatcctttga tcccgtaaaa tgatggagtg ttgtcggaaa ctgctcttcc gtcacaagac 2444881 ggaaatcgac gcttgtttca tattcaaagg aaaggatgac ggacaccttc gtatctccgc 2444941 ttgcgatcac gcttttgatg tttggcagct caagaagctg ctctcttact tcagccggat 2445001 gatctgtagc aatgatataa tccagatcct tcaccgtttc ccgcgctctg cggagacttc 2445061 cggcacgaga aaatttgatg atatgcgtaa attgagaaag atgctcctca atttcccgcg 2445121 cgatccggag ggcgtagccg atcgggaacc gttcaggctg ttttccggct tccccgagcg 2445181 cctgtaatat tttttcttcc gattttttgc cgaagcccgc aagaccctgg accttttgct 2445241 gctcacaggc ttccttcaga gattctgcat cgtgtacgcc gagctcttta tacagctttg 2445301 cgattttttt gccgccgagc cccggcagct tcaataaagg cacgagtcct tccggcactt 2445361 ctttctgaag cgattcgagc gtgcttgact ttccttcatc tatatactct ttaatgacgc 2445421 tgtacgttcc ttttccaatg ccggacagcg acatcatatc gtccatttct gataagcttc 2445481 ggtcgtcctg ttccagagct gccgccgctt ttcggaaggc ggatacttta aacgggttgt 2445541 cccctttgag ttccatatag actgcaatgg tttcaagcag ccggataata tcttttttat 2445601 gcatatcata acccccagac gttcacatat gtttccatca tacttgaaaa aaacttctcc 2445661 ggacaagaga agttttttta tgccccgtac tgtgtccaca gctcttgtaa aagccctgac 2445721 aagtacggtg tatggttaat gatcacattt gcgagagacg attgccccat catttgctgc 2445781 aacgcgtcta ccggcagaac ggatgcgaca tacagcagca caaatgtaaa taaatagact 2445841 tctagaaaac cgagaacggc tcccagcatc tggttgattt gtttaatcac cggaatgccg 2445901 gctacaatac tcaggaacga gccgatgatt ctcagtaaga ttttagcaat gataaataaa 2445961 acgataaacg caatcgcatt atagtacgct gcttccaaat tccccgtaaa aaaagaaaga 2446021 gccggctgtc ccgctgaaaa atcgggtgcg ggaatccaat gtaaatgcgg tgccacgttt 2446081 ttatagaata aagccgcaaa ggcaattgat aaaataaagc tcgtcaagcg gataaactgc 2446141 aggataaaac cgcgttttaa ccccagtaaa gtccccatca ggagcaagat taagatgatg 2446201 atatctagca tagttgttca atccttttct ttaagctgac gctccagttt ttcacatttc 2446261 tcttgtaatt tgacataatc gtgcaccaca tttaccgctg tcagcactgc aagtttattt 2446321 atatcaaggt atggattttt ttcattgatt tctctcattt tatcatcaac aattccggcg 2446381 acatacctca tatgggctct gctttcttca ccgacaatcg tgaagtgctg gccgtaaatg 2446441 tcaacggttg tttttgtttt tttgccgtca gacaacgttt ctcctccatt ccgcgagaat 2446501 cctagttctt atcataacac gtttattaaa tgaatggaaa gacgagcctc ccgctgttat 2446561 gatacactgg tatatacagc gaaaagtgta aaaaaaggag attattacgt gtcccattca 2446621 gtgataaaag tatcgttgtc tgctattgac caaatgaaaa tgacgtacag cggttcactt 2446681 acagcctctg ttccgcaggg agccgttttt caggcaaaac cgcccggctg taccattaca 2446741 gcatatcaat caggtaaggt cttgtttcaa ggaaaaaacg ctgcggcaga atccgcgcgc 2446801 tggggaacag cagagcctca ggaaaagaag aaaacggcca aaaagccggc tgatccccgc 2446861 tatgcccctc cggcagatat cgccggaatg tctgttatcg gttctgacga agtcggaacc 2446921 ggagattact ttggcccaat gacggttgta tgcgcgtacg tcgacaaaac catgcttcct 2446981 ttaatgaagg aactcggtgt taaggattct aaagatttaa aagatccgca aatcatcgag 2447041 attgcccgaa acctgattaa aaccattccg tacagcctgc tggtgttaaa gaatgaaaag 2447101 tataacagca tgcaggaaaa aggcatgagc caagggaaaa tgaaagcttt gctgcacaat 2447161 caggcgatca cacatttatt aagaaaattg gatggagtaa agcctgaagc cattttgatt 2447221 gaccaattcg ctgagccagg cgtctacttc aatcatttaa agggcagaga cattgtgaag 2447281 gagcggacct attttagcac aaaagctgaa ggtattcacc tggctgtcgc cgctgcttca 2447341 atcattgcaa gatattcatt tttaatggaa atggataaac tatcacgcgc ggcaggaatg 2447401 acgcttccaa aaggggccgg tccgcacgtc gatgaagcgg ccgccaagct gatcctcaaa 2447461 aaaggggcat ctgcactcag aacctttaca aaactccatt tcgccaatac gcaaaaagcg 2447521 cagcgccttg ctgataaaaa acgttcatag aaaaaagctt gcagatttct ctgcaagctt 2447581 ttttatcagc ctcttaaaac agcttgatat gtgtcttcta acgctttcag cactttgctg 2447641 tgcgcctttg tcacttcttc ttcagtcagt gtttgttcag gattgacata ctggagtgag 2447701 aaagcgactg acttcttgcc ttcctccata tgctctcctt cgtatacgtc aaatacggtt 2447761 acctctttca gaagcttgcc cccggcctct ttaatgacgc tctcgagctg tccgcttgtg 2447821 acggttttat ctgttacaag agcgatatca cgtgtcacag acggatattt tggaatcgcc 2447881 gtgtaaacaa gcggtgctgt ttctgctgcg agcaacgcat gaagatcgag ctcaaatacg 2447941 tatgtttcct ttatatccag ttctttttcc aatgaaggat ggacttggcc gatgaagccg 2448001 atcagagaac cattcaataa aatgttcgct gttctgcccg gatgcagctg tttgcgttca 2448061 gactgtacaa attcaatgct gtctaggacg ttgagtttgt ctaacagccc ttccacaatt 2448121 cctttgacaa caaagaaatc aactggtttc ttttcaccct gccatagctg cttgcgccat 2448181 aatccggtaa cagctcctgc tacgcgttct gtttcaacag gttttgtgtc ctcttccttc 2448241 gttaggaaaa cggagccaac ttcgtacagt gcaactgagt cagtctgcct cgcaagattg 2448301 taagaaacag aatcaagcag atttggaaca agactgtgtc tgagaatgct tctttcttca 2448361 ctcattggaa gcgcaagcac agtattcagt gatttttcaa tcgcaaacgc tgtcgctttc 2448421 ttctcgtttg tcagtgagta agtgatggct tgtgataagc ctgcgccttc aaggaagcgt 2448481 ctgactttac ggcgttttgc ctgatatggc gttaatccgc ctgtagttcc cgctgtctca 2448541 ggaagcgtag acggaatgtt atcgtagccg tacagtcttg ccgcttcttc gattaaatcc 2448601 tcttctattg taatgtcacc gcgccgtgat gggacagtca caacgagaag atcatccgct 2448661 tcaccgaccg taaaaccgag acgtttataa atgctgatca gttcttcttt actgatcgtc 2448721 aggcctagaa cgctgctcac tttgtcagca gatacgtgaa tgttatttgc ttcgattgtc 2448781 aggtgatctt cctcaaccgt tccagcaagc acctcaccgc cggcatacag atggatcagc 2448841 tgcgcagccc gttctgctgc aagacgtacg cgtgccggat caattccttt ttcaaatctt 2448901 acgcttgatt cacttctcaa accaaggtct ttggaagcct tgcgaacctt ctgcccgttg 2448961 aaatacgcag cctcaagcaa aatggttttc gtatcttcct gaacctctga ctctgctcct 2449021 cccatgacac cggcaacggc ctgcgctttc gttccgtttg taatgacaag gtgatcggca 2449081 gacagcttac gttcttgatc atcaagtgtt acgatcattt cattctcagc tgcttttctt 2449141 actacgactt ccttagagcc aaatctgtca taatcaaacg catgaagcgg ctgtccgtat 2449201 tccaacagga caaaatttgt gatgtcaacg acgttgttgt gcggacgaat gcctgcattc 2449261 atcagctttg tctgcatcca aagcggtgac ggagcaatcg tgacattttt aatgattttt 2449321 gcagtgtaca gcgggttcgc ttcttgatct tcaattttga ctgaaatgta atcagacgct 2449381 tgttctgaag cagccgggta atccgtttgc ggaagcttta cctcagtgtc taaaatcgcc 2449441 gcaacctcgt aagcaacacc aagcatgttc atggcatccg cgcggtttgg cgttaaaccc 2449501 agctcaagaa tcgcatcgtc aagctgtaaa gccgctaagg catcgcttcc tgtttcagcg 2449561 tcattcggga atacgaaaat gccttctgca tactccttcg ccacaagttt gctttcgata 2449621 ccaagctcct gtaaggaaca gatcatgccg tttgattctt caccgcgaag cttggctttt 2449681 ttgattttga aattgcccgg cagcaccgct ccgactgttg caactgcgac tttttgtccc 2449741 ttatccacat tcggcgcgcc gcaaatgatt tgtacagggg cttcagctcc gatatccaca 2449801 aggcacttat tcagcttatc agcattcggg tgctgctcgc gctccagcac atggccgatg 2449861 acaacgcctt tgatgccttc tcctttgtat tcaattcctt caacctcaat accggctctt 2449921 gtaatttttt cagcaagaac agccgggtcc atgcctttta aatcaacata atcctctaac 2449981 catttataag aaacaaacat ccttgcatcc tcctcttacg cctgtttaaa ctgcgaaata 2450041 aatctgacat cgtttgtata gaagtggcgg atatcatcaa tgccatattt cagcatcgcg 2450101 atgcgctcaa cacccattcc gaatgcgaag ccctgatatt ccttcggatc aaagccagcc 2450161 attttaagca cgttcgggtg aaccattccg gcaccgagga tttcaatcca gcctgttcct 2450221 ttacatactg agcagccgtt cccaccgcat ttaaagcatg tcacatccac ttctactgaa 2450281 ggctcagtaa acgggaagaa gcttgggcgg agtctgattt cacggtcttg cccgaacatt 2450341 tttttcgcaa caagttcaag cgttcctttt aaatcactca tgctgatgtt tttgtcaacg 2450401 acaagccctt caatttgcat aaattggtga gagtgcgtcg catcatcgtt atcacggcga 2450461 tatactttac ccgggcaaat gattttaacg ggacctttgc cttcatgctt ttccatcgta 2450521 cgtgtttgga caggagaagt ttgcgttctc atcaaagttt cctctgtgat gtaaaagctg 2450581 tcctgcatat cgcgcgctgg gtgttctttc ggaagattga gcgattcgaa gttgtagtaa 2450641 tccgtttcaa cctctggccc ttcctcgact gtgtagccca taccgataaa taaatcttca 2450701 atttcttcaa tgacaacagt gagcggatgg cggccgccga ctgcaacagg gttccccggc 2450761 agcgtgacgt caattgtctg tcctgcaagc ttctgtttca tttcctcttc ttcaagcttc 2450821 tcgtttttgt cagcaatcgc attggcaata cgctccctta cttcgttcgc gagcgccccc 2450881 atttttggac gttcctcagc agaaagcttg cccattccgc gcagcacttc tgtaatcggc 2450941 cctttttttc cgagatattg cacccgaata tcattgacaa ccttcaatga gcttgccgct 2451001 tctacttgtt ctaaagcttc ttgttccagc tgttttagct tttcttccat tttgcatcct 2451061 ccttttatgt aaacaaaccg tcatatgtct ttggaaaata aaaaaaaccc gtcccttgta 2451121 caagggacga gttgtggccg cggtaccacc cttatttcag acagactgat gctgtcgtca 2451181 gcttcattga cataacggaa tcagattccg gttcaccttt acgcgcagtg tacgcggtcc 2451241 cggcgacaac tcaagaggtg aagccaattt ccggctgcgt taaaaatgct ctcagtcagc 2451301 ggcattttct ccctggaaag cagttgatca gaaattgagg tcctctgtca cggtttttga 2451361 aatattatgt tctattatag agaaatccaa cgcttggcgc aacactatcc tcgcaagtga 2451421 tacacgagga tggcagccgc aaccgcaacg tttagtgatt cagcctgtcc gtaaagcggc 2451481 acgtacaggt tcaaatccgt tttttccagc aatgcagcat ctacccctgc accttcattt 2451541 cctacaatga gcgcaaagga ttcagactga ggaatctcct ggtaaggcgc tccgttttgc 2451601 agcgccgtgc cgtatacttt tacgccctct gccttcaatt cgtccacata tgaaggcagg 2451661 tttcttctca caacaggaat atggaagtga gatccttgag cagatcgcag tgtttttccg 2451721 ttaaaggcgt ccgccgtgcc gtcaccgagt acaaccgcat ccaaaccggc cgcatcagcc 2451781 gttcgaatca ttgtgccaag gtttcccgga tcttgaacag cgtcaatcag cagcaccttg 2451841 cgtgccgttg ccagcttttc ttcaggcata tggcacacag cggcaatctg ctgcggcgtt 2451901 tcggtttcag tcacagctga aaacgcatct tcactcagca tatagcactg gataccagtc 2451961 tcaagatctg aaggaatcct cgtttcatcc tttacaagga tttctttcac aatgcccggg 2452021 cttttcaacg cctcttcaac gaggtgttct ccctctatca gaaatgtatt tgtttttgtt 2452081 cgttcttttt ttgtgtgaag ctttttccaa tccttcactt tttggttttt tgccgattct 2452141 atttgtttca ctgtctatgt ggcgctcctt tttttaacat gatgttatta tatcgcaaga 2452201 acagcacata ataaaccagg tgcagggtta gaatatacgt attacatttt agaaaaagga 2452261 gcgttttaca tggatcttaa tttacgtcat gccgtcattg ccaatgtcac cggcaataat 2452321 caggagcagc ttgagcatac aatcgtagat gcgattcaaa gcggtgaaga aaaaatgctt 2452381 ccagggctcg gcgttttatt cgaagtcatt tggcagcacg catccgaaag tgagaaaaac 2452441 gaaatgctga aaacgcttga aggcggatta aaacccgccg aataagacat gaaaccgggt 2452501 gacagcgccc ggtttttttc ttatataata aaaacatgat gagggggaac gccatgtttt 2452561 tacagccgtt attagcgaaa aaaattattg ctgaagttaa aaaaatgtac gaacgtgaag 2452621 tcattattgt aaacacggac ggtcttatta tggcaggcac aaacgatgag cgtgtcggac 2452681 aatttcatga gggagcgctt atctgcgcaa aagaaagacg cagcgtgatt attacaaaag 2452741 aagatgaaac aaggttaaaa ggagtgaaag caggcataaa cctccctgta ttttttgacc 2452801 atgatgtgat tgccgtcttc gggctgacag gtgagcctgc agagattcag ccattcggag 2452861 aactgcttcg aaaaatgaca gaactgttca ttaaggaatc gcggcactta gagcaatccc 2452921 agtggcgtga gagaatgctg gagtccttta tgatcgattg gctgcaatta aaggagtggt 2452981 ctcccagttt tcttgagaaa gctcagcttc ttggtgttga cctttcttcc cggcgccaaa 2453041 tgattcttat tcaggggtat gagtggtcac ctcatgatat tgaacaaatg gcacgcagct 2453101 ggaaatcctc gtaccctgcg gatttgttca tcaggtgggg aaatgaacgg attttgatta 2453161 atcatgaagt gccgcagcat gaacaaaggg atcggctttt gcggaaaatc cttcacattt 2453221 gttcgtttgc caataccgca agcagccaat atacagcagc tggcgccgga agggctgtcg 2453281 caagctccag cctgacagat tcatacgagc aagcggaaaa agcgctggct gtcagcctta 2453341 agcgaaaaac gcccatattt gaagaggatc tgaagcttga tatgtgtctg acggagatca 2453401 gcccgggaac ccgaaacgaa tttccgcaaa gagtattagg aaaggcgcta gagcatcagg 2453461 aacttatgaa tacgatacgg actttctttc atcacgattt gtctttgaaa caaaccgctg 2453521 aagacatgca tatacacatc aatacattgc gttatcgtct ggctaaggct gaacagctga 2453581 cgggattacg ttttgaccgt accgaggacg tcgtcacgat gtacgtcgca ctctattttt 2453641 tagatcaaga tacaaaatag agagagtttc agtttcattt tttgtatgtt tctccatgga 2453701 aggctttgct ttttttcttt tacaatagat tgaaagcgtt ttttgacagg gggatgggtg 2453761 aaatgatcac caaggatgta aaggagcagc tgattcaggt ctccggacca gaaaactttg 2453821 atgactcgaa tgccggccgt ctcgtctatt catatgatgc gacgcctcag tatcagtcta 2453881 tgcctgatgc cgtgattgct ccgaggaata ctgatgaaat atcacgcatt ttaacaattt 2453941 gcagcgaaca tcgagtgccg atcgttccaa gaggatcagg gacaaacctg tgcggcggca 2454001 cgtgcccgac tgaaggcgga cttgtgcttc tctttaagca catgaaccag attcttgaaa 2454061 ttgatgaaga aaatttaact gccacagttc agccgggcgt cattacgttg gatatgatcc 2454121 gggcagttga aagcaaaggt ttattttatc cgcctgaccc gagttctatg aaaatatcaa 2454181 ctatcggggg caacatcaat gaaaattccg gcgggctacg cggattaaaa tacggtgtca 2454241 cccgcgacta tgttattgga ctggaggttg ttctcgcaaa tggtgacatc atccgcaccg 2454301 gcggaaaact cgcaaaggat gtggccggat acgatctcac acgtcttttt gtcggctcag 2454361 aaggaacact cggcattgtg acagaggcaa tcgtcaaact cgttccaaag ccggaaacaa 2454421 agaagacgct gcttgccctt tatgaaaaca tcgatgccgc tgctcaaacg gtatcggaca 2454481 ttattgccgc aaaaattata cccgctacgc ttgaatttct cgatcagcct acactattgg 2454541 tgattgagga ttatgccaaa atcggacttc cgacaagcgc aaaagcagtt ctgttaattg 2454601 aacaagacgg gccatttgaa actgttgaac gggatatgga aaagattgag gcgatctgca 2454661 aaaaaggcga cgccgtatcc gttcagaccg cacaaacaga ggaggaagcg tttgccctga 2454721 ctgaagcccg gcgttctgca ctttctgccc tagcccgcct caaaccgacg acgattttag 2454781 aggatgcgac cgttcctcgc tcagaaatcg ccaatatggt taaagcgatt aatgatattg 2454841 ctgctaaata tgatatttcc atctgcacct ttggtcatgc gggagacggg aaccttcacc 2454901 cgacatgcac gacagacata agaaataagg atgaaatgga acgtgtcgaa caggcttttg 2454961 ccgagatttt tgagaaagcg attgaacttg gcgggacgat aaccggagag cacggagtcg 2455021 gggaaatgaa agcgccttac ttggaaatga agctgaaaaa agaaggcatt gatgcgatga 2455081 aagcgttgaa agcggcattt gacccccgga acatattaaa tcccggcaaa atgtttgcga 2455141 aagatgccag aaaacgtgtg gtggcggaaa gatgacaaca gaaaaagaaa tgaaacagat 2455201 ccaaaatgaa tttaaagagc gtatggatga aggagagtta ttaaattgta tgcgctgcgg 2455261 cttctgtctt ccttcctgtc cgacctatat cgaatcggga tttcaggaaa cacactctcc 2455321 gcgtgggcgc atcgccttaa tgaaagccgt agccgacggt atgattgaac cggatgaaga 2455381 tgtcgaacgg tcgctgtcac tttgcctcgg ctgccgcgcc tgtgagcctg tatgcccgtc 2455441 tggcgtgaaa tacgggcagc tgcttgagga agccagagat attatccacc aaaataaaaa 2455501 acactctctt ggtgaacgtg tcatgcgaaa gacggctttt cacgagctgt ttccgcatca 2455561 aaaccgcatg cgctcagctg taagccttat cggtttgtat cagcgttcag gactgcaaac 2455621 cgctgtgcga aaatcaggca tgcttcgggt cctgcctgag catttgcgga cgatggaagc 2455681 tgttcttcct gatgttccaa aaagcaaaga catgaaacat cggccgcgtt tcctgccttc 2455741 cattggcccc atgaaaaaac gggtcgcctt tttttcgggc tgcttaatgg atacaatgtt 2455801 tttaccgacc aataacgcca cattgaagct tttacagctg gcaggctgcg acattgtcat 2455861 tccgcctgaa caggcttgct gcggggcgct tcatggacac agcggtgaaa aaaacacagg 2455921 gaaagagctc gcgaaacaaa atatcgctgc tttcgaagca ttagacgtgg atgcagtcat 2455981 tacaaacgca ggaggatgcg gagcctttct cactgaatat gatcatttgc tgaaggatga 2456041 ccctgagtgg tcggaacggg ctgccgcttt tgttcaaaag ctgaaggatt tttcttctgt 2456101 tttggttgaa ctcgatttcc atcaaatgga tctagcactc gagacgcctc aggtcgttac 2456161 ctaccaagat tcatgtcatc taagaaatgt gatgcatacg tcacttgagc cccgccagct 2456221 tcttaaaagc atcaaagggg cggaattcaa agaaatggag aaagcagaca gctgctgcgg 2456281 gtcagcggga atttacaaca tcgtcgaagt tgaaatgtct atgaaaatac tggacagcaa 2456341 aatggctgcc gtcaaagcaa ccgaagcgat cctcattgta acagcaaatc ctggctgcct 2456401 gctgcagatg aagctcggca ttgaacgcga aggactaagc ggtaaagtca gagccgttca 2456461 cctggctgat ttgctattag aagcagccgg gcacaaaaca tcatgagaaa gcccaaaaca 2456521 gacattgttt tgggcttttg tgcgttattc catcggactg caaatttcga tataatgtcc 2456581 atccggatca gcgatatagg cgaccgtctg cccccatggt ttcactttcg gctccccgat 2456641 aatcgatacg ccttgttctc tcatcctttt gatgaccgct tctacatttt cagtaacaaa 2456701 cccgatttca aatgtgtttg aagcagatgt atccggaatg tccagcgccg tgatgtctct 2456761 ggcgctttcc cgggtattaa gcgccaatat cgtagaccct gtatcaaatt cgacatacgt 2456821 gccgtgttca gcacgaatcg gcagtcctaa aatatcccgg taaaaaatga atagcccgct 2456881 tgctgtccga tacgtataga ataagatatt tcattgatag attcattgcc aacccctctc 2456941 agcattttca atagtccttc tagcccggta tagatgcttc catccttaag ctcggatctt 2457001 tccacatctg cgcccatttt ttcacagccg ccacgataat gatgaagcct aacaccagca 2457061 tgatgataga taatacgcca ttcaatacac tatatcctgc tgcttcagga ttgagataca 2457121 cattgcgcac catccaatag cccgcataat tgacagtgac atataaatag gcaagcggga 2457181 taaggcaagt cagaatgtac cggcgtttat cggcgatttt cagcacgatc gtcgctccga 2457241 taatcagccc cactgaagcc atcagctgat tagaaacgcc gaagagcgcc caaatggaac 2457301 cgatatctcc tgaatacagc aagtaccccc acatcaaaca ggcaagcgcg ctggcaaata 2457361 cagagcccgg aatccagtct gttttcttca gcggcttata cacctccccg aagaagtcct 2457421 ggatcaaata acgggcgaca cgtgtgccgg cgtcaatcgc tgttaaaata aagaccgctt 2457481 caaacataat gacaaattgg aaaaagtatg aggccaaatg gctgaaaaac ggcattccgg 2457541 taaaaatata agtcatccct accgcaagcg tgacggctcc ccctgttctt ccttctaagt 2457601 ccaaaccgat ttccccgctc aattcaggca aatgtacgac attcatgcca agcgtacgga 2457661 aaacctcagg cgtgctgtta atcgcaaagt aatcagcagg ctgtaaagcg gtcgctgcaa 2457721 tcagcgccat gataccgaca agacactcaa caagcattgc gccaaacgca accggcttca 2457781 tatcactcca tttattcagc attttcggtg tcgttcctga gccgacaaag gcatggaacc 2457841 cagagatcgc cccgcaggcg atggttattg agatgaacgg ccagacaggt cctgccagca 2457901 ccggccctcc gccttttacg aattctgtaa acgcagggaa cggaatggac ggattgacga 2457961 caaacacacc aacaatcaaa gcgataaaaa caccgatttt cataaagctg cttaaataat 2458021 cacgcggagc cagaagcagc caaacgggaa gcgcagccgc aaaaaacgca taaacaggaa 2458081 gcgcgattgc aagcgttttc gtatctagcg ttaaaaagtc accgagcgcg gtagtctgta 2458141 cccatggacc gataaagact cctgccatta aaaagagaaa gccgaccgtt gaagcgagct 2458201 ttaaatttcc cgttttctta taaaataagc ccacacccat cgcaatcgga atcgtaatcc 2458261 ccaccgcaaa tgttccccat ggattacgtt caagcgcatg caagacaacc atcgacaggc 2458321 ccgccattgt gatcgtgatg ataaacagca tggacagtcc tgtacaaaat cctgcaacag 2458381 ggccaagctc atccttcgcc acttccgaca gcgattttcc gtttttgcgc atcgatgcaa 2458441 acaacaccac aatatcatgg acggctcccc caattaccgc cccgattaac agccacaata 2458501 atcccggcaa atagccaaac tgcgccgcca gaattggtcc gaccagcggc ccggccgctg 2458561 cgatcgcggc aaagtggtgg ccgaacgaaa cccatttatt tgtaggcaca tagtctttcc 2458621 catcctcaag cgcatgagca ggtgttggct tgtcatcatt cactttgaga accttcacca 2458681 tcataaatgt tccgtataaa cgataggcaa tagccaaaat acacattgat gctatcacaa 2458741 ttgtaaccgc attcattttc tcccatcccc ttttctgttt ttcataaata tatcataatt 2458801 tcatggtgaa aagcggtcat tttttcctat acaaaaagcc ggctggaatg ggccggctcg 2458861 tggcagttga aagacaagcc ggagagaaat ctccggcttt gctattctta tgactgtttt 2458921 ttcaggcgga tcacattcca ggaaagcggc gtgaaatgag cagttaagcc gttttcgctg 2458981 acagacgatg atccgttgga atgcggaacg acattttttc tgttatgctg gtttgttgct 2459041 ttgatatcct gatgctcaag tacgatgtgc tctgcgattt ggtaggattc aaagcctctg 2459101 agcgaaatct ccgtctccat ctgatcctca gccttgttta ccgcaaaaat agtgagtgtt 2459161 tcttcctctt cagagtacac aacagcagca tcaacatatg gcacatcagt gaaatcagaa 2459221 caatcgtact taggagaaga aataagcggt ttcagtgact cgccccttcc gtaaacagaa 2459281 gcatgcatgt atggatagaa aatcggctgt ctccatgctt ctccgccttt ttccgtcatg 2459341 atcggcgcga tgacattaac aagctgtgca agacacgcaa ttttcacacg gtctgcgtgc 2459401 tgcagcatcg taatgagcag agagccgact aataaggcat cttcaaaatt gtaaatatcc 2459461 tctaaaatcg gacgcgcagt gatccacggc tcgacttttt tatcagcctc atttgagtgg 2459521 taccagacgt tccattcatc cagagagaga ttgatagttt tcttgctgcg tgtttttgct 2459581 tttacatagt cacaggtcgc agcgactgat ttgataaaat gatccaaatc catagaacgt 2459641 gccaagtagt ttggcagatt gttatcccgg tttccgtagt aagtgtgaag agagatatag 2459701 tcgacatgct catacgtatg ctcaagcacc ttcgcttccc aatcgataaa ggtcggcata 2459761 ccgctgtttg agctgccgca ggcaacgagt tcaattgatg ggtcaaccca cttcatgacc 2459821 tttgctgtct ctgcggcaag ccgtccgtat tcatcagctg ttttgtggcc gatctgccat 2459881 ggtccatcca tttcgtttcc taagcaccat gttttgatgc catacggctg ttcatagcca 2459941 tgcgatcttc ttaaatcact ccagtaagag cctttcggat ggttgcaata ttcaacgaga 2460001 ttacgggcgg catctatgcc tcttgtgcca aggttgacgg ccatattgac ctcagtgttc 2460061 accttttttg cccaagataa aaattcattt gttcccactt cattggtttc tgtcgtttgc 2460121 catgccaagt caagccgtct cgggcggttt tcgactggtc cgacaccgtc ctcccagttg 2460181 tatccggata aaaagtttcc gcccggatag cggatgatgg gaacctgtaa ttctttgatc 2460241 agcgactgga catcttttct aaatccatct tcatccgctt cagggtgatc aggctcgtat 2460301 atgccttcat ataccgcacg acccatatgt tcgataaacg agccataaat ccgtttatct 2460361 acttcaccga ttttatattc tttgtctaca atcattcgcg cttttttcat cacacgtttc 2460421 ctccttcatt aacctttgac tccccctacc gtcaggccgg agataaagta cttttggaaa 2460481 aacaagaaaa tgataatcac cggcaaaatc gcaaatactg agccggatat aagcatgtcg 2460541 taattatttc cataagggct cagcaagctg gacagcccta ttggaagcgt aaacatttct 2460601 ttcgaccgaa gcacaatcag cggccacaag aagttgttcc agctgtttaa ggactgaagg 2460661 ataatcatcg caccgaaagc cggtttcatc agcggtgcca taatcctgaa aaagatgccg 2460721 aattccgtac agccgtccat ccttgcagag tccagcagat ctcttggaag gccaagagca 2460781 tattgcctga aaaagaaaac agcaacaggt gaaacgataa acggcaatat gacacccgta 2460841 tatgaatcga tcaagtgcag tccgacagta agtttaaaca gaggaagcat catcacttcc 2460901 agcggaacca tcataataat cagcacaaga acaaagatga tatttctgcc cttaaaatca 2460961 taaaccgcaa gcccgtaccc gatcatcgaa gaaaaaaaca gagtgagcac agtcgtaaaa 2461021 agtccgagta caagactgtt aaaaaaccat ttgaaataaa tgctgccgcc attaaacaga 2461081 aatgtgtagt tatcaaaact catcactttt ggatcaatat caagattcag ccccacacgc 2461141 aaaagctcag atgacggctt taatgatcct aaaagcaaac agaaaatcgg aaaaagatac 2461201 aataggctca gcatcataaa aaacagggtc agcgcaattc tataaacgct aaactgagga 2461261 ctgtgccgca acatttatcc ctccccctta aacgagcctg acagctttaa tgaaatcagg 2461321 ctgacaacaa ggatcacaat caaaagcaca atgccgatgg ccgctccgta tcccatttca 2461381 ttgtaggcaa gtccctgctg atacaaatat ccgacaagcg tcagaccaat attacccggg 2461441 gaattattct gccaaaggac gtagctttcc tcaaacatcc tgaagccgcc gatgatgctg 2461501 atggtcagca catatacggt tacaggcttg agaaacggca gcgtgatgtg cagaaatttt 2461561 ttcattgtat tcgcgccgtc tatatcagcg gcttcgtaca gctctttcgg cacattttgc 2461621 aaacctgcta aaaagtaaag gatgttgatt cccatccatc tccatgaagc aagcagcacc 2461681 atcaaaaaca tgccggtatg ttcattgttc atccagttct gaggtgaaaa gccgagttta 2461741 agtaggatgg aattggccag agacgtttcc atttctccga agatcagccg aaaaatgatc 2461801 cccgcgacaa tggttgaggt caatgccggg ataaataatg ctgatttaaa tatatttcta 2461861 aatttgacca gctttgaatt caggaatatg gccagaagca atggaacagg aatcagcacg 2461921 atcagcgtcc aaaaggtgta ttccagcgta ttccaaaggg cggtatagaa cgtcgggttg 2461981 tttagcgctg tataattaga caatccgaca aaggacacct ctcccggcaa aattctttgg 2462041 aagctcatga tgaagacact aatgatgggg tatagaaaaa atacgagaaa ggataaaacg 2462101 aatggcgctg taaacagata gggcgccgct ttttttgaat aaaacagatc tcgccagcct 2462161 gattgtttcg cagctgaagg aacgggatga accgttcccg ttttcacagg tttcatgaga 2462221 acctccccgc tttcactttt tgaatgggat tctatttctg tttcagttca cctgccgctc 2462281 tgtccaaggc ttgtttaggc gttttttgct gagatttaag cgcgtcgaac aatacgcttc 2462341 tgttgacaag gtctgaagcc ttggcaaaat cctcatgtaa ataaattgga ttgatttcat 2462401 ccttgatatc gagcagcaca gaaaaaatgc ctgttccgtt ttggaagtaa tccgtgtatt 2462461 tgtttttctc tttcaattcc ttggagctcc aaacatccca gcgaagcggg tcaaagccga 2462521 gtacgctcca gagtttttta tttccttctt cagagccctt cgcaaaggcc aaaaactctt 2462581 ttgctaactc aacatgcttg gattgcttcg gtacaacagt tgccgtaccg cccaaacctg 2462641 ccgagcggtc gcccccctct ttccatgccg ggagcggtct gatggcaatc ttccctttca 2462701 gatcaggcat ataatcgata aatcttccca tataccaaat cggcatgaga actgaagcag 2462761 ctcctccttg gttcataaag ccgtagtatt cttcactgtg atgcccgccg cccggcgcag 2462821 gaatcatcgt tttatcattg atcatgtctt ttaaatattg aagtgttttt acgttggtgt 2462881 cattattgag gatcagcttg ccgtttttat caaaatagcc tgagttttgc tgtgaaatca 2462941 tagataagaa cgttgcggaa tcatttgttt ccaccgttcc catcggcttc ccggtcactt 2463001 tgcgcacttt ctgtccggct ttatggtaat catcccatgt tttaatatcg tcaggattga 2463061 cgccggcttt tttcatcaca tccatgttat aaaacatgac cgttgtccct acatgtgtat 2463121 cgagtccgta aagctttccg tttttgctgt acaatgtcag ccgcgcctca acgaatttat 2463181 cgcgatcctt ttcaatcagc ggagtcaagt cggcaagcgg tatgtcagag cccttcaaaa 2463241 agtttgaaaa acgggccaat tcgacatctg caatatcagg aacgccttct cccgctatta 2463301 gggagataga taagttatcg tgcatttgtc catatggata aacgaccgta ttcagcttaa 2463361 ttttgcggtc aggatatttt ttgttccatt ccttcaccat ttccacatag aactgctcat 2463421 gaagcccgtt aaatgtccaa aaggtcagct cagtttcacc cgatttgccg gatgattttt 2463481 ctgctgaaca cccggcaatg actaatgtca gcaacatcat gagcacaaga aaacagacag 2463541 tcattttttt catctgcgtt accccttcca ttcgaggtgc gggctattca tatagaccat 2463601 ggttgatcag cgttttgttt tcattgatga ttcttaatcc ggtgcatcgg tctcttaagg 2463661 tgtgcgcgtg tctgaaggca tttttgacgg aatcctgccc gacaccgatt tcgtcaaaat 2463721 acgcagggcc tccggctgat ctcagccaat cagccagcac ttctcctctc gggagtgttt 2463781 gataagccga ttggatggct tcccggcggc ttggtgaaaa ttcgttcagc ccgtcatcct 2463841 gagcgagctt tctgtatgtg tcagttaata aaacagcggc acagcccacc tttgccccat 2463901 gaagaatctg aggccgtttt ttctccatta actccatttc aatccaatgt gaaatatgat 2463961 gctcgccgcc tgatgccggt cgggaatgat ctaatgccag catgacaagc cccgatacaa 2464021 gtaaagactc catcaaaacc cgtatgccag tttccgtttt catcgcaatg tcttctgtgt 2464081 gttcaatgca ggcagcaagc gcctcctgaa cgatcttagc tcctgcaggc gaataaggct 2464141 caccggcaag atgccgggat atttcccaat ctgctaaaga cgtgatttta ccgagcatgt 2464201 caccaaagcc agccgccacc attgactgcg gtgccgcttt taatagatcc agatcagcga 2464261 acagcgcaga tggggccttc gtttgaatgg ttgttttcgt gccgtataaa ataatcggcg 2464321 caccggctga tgtaaaaccg tctacagatg gagcagtcgg ataagaaata aacggcaaat 2464381 ctctttgaaa cgccgcaaag cggacgatat catgaatcgt gcccgaaccg actgcgatca 2464441 tgacatccgt tggttgtttc gtatggatca gcacatgaat gagcgatcgt tcatcagctg 2464501 tcacatctcc ggcttcattt tctggaatga tcaggcactc ggcctgaaat ccttcttgat 2464561 tcagtcggtt ttctaaatca attcctgcaa tgcggtgtgt attcgcgtcg cagacaagga 2464621 caatatgttg attgtttttt cgttttacat aatccaaaag cgaatcagct gcttgcttac 2464681 cgagaacaat ttcttcaact tttataggca acgtcttttc tccggcgttt tcaaaagcac 2464741 gctgaacgtc agctgcgata cgattcatat cagaatcccc tcctcagcca atttggttac 2464801 atccttaata gaatccagca cataatccgg cgtgtacaaa cgctgttcac cctgtttcgc 2464861 agaaccagtt agcactaagg cgcttttcat gccataaagc ttccccatcg caatgtcaga 2464921 ttcaatgctg tctcctataa tcatgcattc atgtgcggac agccccattg ctgtacaggc 2464981 agcctccgcc atcagccatg acggttttcc gacaacaagt tcagtcttcg cttgtgcaga 2465041 agtctcaatt gccccgatca ttccggccac atcaatggca tttccgtctt cgttcggaaa 2465101 agagcggtct ttgtttgtag cgataatacg agcgccgccg gcagccgctt gaaaggcttg 2465161 atttaaatcg tcgtacgtga gcgtttcatg aagggagatc acgagccaat ccgcttcctt 2465221 cggttcgctc gcgttctgca caccggccag cctcagctcg tcaaccaagc cttgctcccc 2465281 aagcacccat acctttgaaa aacgataatg ttttttcaga aaagccgctg tcacgcttga 2465341 tgacagaaca atgtcgttta cgtccgtttc aatccccgcg ccaagaagtt tttttctgca 2465401 catggcacgg gagatattcc cccggttgct taaaaagacg attttctttc ccattctcct 2465461 aagcgttttg atcgcttctc ttgctccttc gatcaactca tttcctctga atacagtacc 2465521 gtccaagtca atcagaatgc cagccggtga cacaggcgta tcatgactgg ccataatacg 2465581 catttgctcc gtgttttcga taaaaatgct tttcatgcag gactgtattg attggggtta 2465641 catccttgtt cagcataatg gagtgatagg ccatttcggc aaccgtttct aatacaactg 2465701 cgttatgaat ggcatttaag gcgtcagtgc cccagcagaa cggtccgtga ttattcacga 2465761 gcacacccgg cacctgttcg taattatgat gctgaaaggt ttccgctatg acttttcctg 2465821 tattcagttc gtagtcatga atgatttctt catcgtacat ttctcgagta catggaatcg 2465881 cactgtcaaa ataatcagca tgggtcgtgc ctaacggagg gatgtctctg cccgattgcg 2465941 cccagcttgt cgcccattga gaatgggtat ggacaattcc cccgatattc ggaaaggctt 2466001 tatatagata aacatgggta ggtgtatctg aagaaggttt aagcgagcct tcgacgacct 2466061 ctccatcaag gttcaaaaca accaagtcat cggctgtcag gtcgctgtat tcgactccgc 2466121 taggtttgat gacaattctt tctttttcac ggtcaatgcc gctgacattt ccccacgtaa 2466181 aggttaccag ctgatgctct tgaagcttca ggttggcagc cagcacttct ttttttaatg 2466241 tttcaagcat gctccatcac cctttatcaa ttctttttgg cggcagatga aaattgaaga 2466301 tttttgatcg ttttcagacg cttcatgaca tggttttctt ttccgaaata atgaaccagc 2466361 tctttatatt cagcgtacaa tttttcataa accgcggcgt tttcggcatt tggcgtataa 2466421 gttatatctt tcagttttcc catgttcgcc gctgcctttt tgatatcatc gtagccgcct 2466481 ttttctttgc ctgctgcaag cgcgccgaaa atggcagatc ctaaggctgg ggcttgcggt 2466541 gaaccagaga ttttaatgtc catgtttgtc acatccgcat aaatctgcat gacaaacggg 2466601 tttttctcag ctattccgcc ggctgcgaac agttcctcaa tcggaacacc gctttctttg 2466661 aatgtttcga taatcatccg ggttccgtaa gctgtcgctt caactaacgc tctataaatc 2466721 tcttcaggct tcgtcagcag tgtcatgcca agcagcatcc ctgttaaatc tgcatcaaca 2466781 agagttgaac ggtttccatt ccaccaatct aaagcaagca agccgctttc accaggcgct 2466841 tgatggtttg ctttctcact cagcagctca tgaacgccaa tgtttttttc ctttgcttcc 2466901 tcttgataag ctggcgggac acatgttttc acaaaccagt caaaatgatc gccgacacag 2466961 gactgcccgg cttcatatcc cgcatagccc gggagaattc cgttgtccac aacgccgcac 2467021 attcctggaa cgatatgcac ctcttcacca agtagaacat ggcacgtcga ggttcccata 2467081 atcatcagca ttttccctgg ctctgtaatg ccgaccgccg gtaccgaaac atgagcgtcc 2467141 acattggcaa ccgcaacagc cgttcccggg agaagccctg tcagctttgc cattttttca 2467201 gtcagactgc cggctttttc tcctactgaa tgaatagaac ctgacaattt gtcctttgta 2467261 atcgttttca ttgaaggatt taatttctca aagaaatcat ctgacggata ccccgctttt 2467321 tcactccaca tcgctttata ccctgcggta caattgcttc gcttgagcga gccgcacagc 2467381 tggtacacga tccagtccgc agcctcgatg atccggtcag ccgcttcata aatgtgaggc 2467441 gcttcctcgg caatttgcat gacctttgga atcatccatt ctgatgaaat ttttcctccg 2467501 taccgctgta aaaaagcctc tccttcttct tccgcgattt gattgagccg atcagcatgt 2467561 ttttgggccg catgatgctt ccagagcttc acatagctgt gcggctcctc ttcatattca 2467621 ggcagcatgc ataacggctg cccgctgctg tcaataggaa ggatcgtaca tgccgtgaaa 2467681 tcaattccaa tcccgataat gtctttcggg tcaacgcccg tctgttcgag taaagacgga 2467741 atggttgttt ccaagacttc gaggtaatca gcagggtgct gcagcgccca gtcacgcggc 2467801 agcttttgac ccgtttttgg aaggacggta tcaatgacag catgcctgta ttcttttaca 2467861 gcagccgcaa gttcctcccc tgtttggaca tgaacgagca ctgctcttcc tgataaagtt 2467921 ccaaaatcaa cccctattgt gtaagccatg tgacatcccc ctctactttt gaagccggta 2467981 aagcgcctcg ttccatttta actcgtgttt cagtttatga attgtcgtat cacgggaaat 2468041 gagaacactt tcgattcccg ccatttccgc ccaatcaagc atttgctccg ctgtcagttc 2468101 ataagacagg caggtatggt gtgcaccgcc ggctaaaatc catgcctccg ctgctgtttt 2468161 caatgacggc tccggcttcc agagaacacg ggcaaccggt aaattcggca tgtctttttc 2468221 aatttcctgg ccgttgactt cattcagcac aaggcggaaa cgcccgccaa tatcaacaat 2468281 gctagcttga atggcagaac cgctgatgcc gttaaatacc aaacgcgcag ggtcctcttt 2468341 gccgccaatc gaaagcgaat gaacctcgat tttcggctga tccaaagcga cagtcggaca 2468401 cacttcaagc atgtgagagc ccagaatcat ttcatttccc ggttcaaaat ggtacgtgta 2468461 atcttccatg aaggaagttc tttttccttt agccatgatt ttcatcatcc gtacaagggc 2468521 cgctgtcttc caatctcctt caccggcaaa cccatagcct ttctccatca ggcgctgaac 2468581 ggcaagtccc ggcagctgtt tcattccgtg cagcacttca aacgatgtcg taaacgctgt 2468641 gtatccgcct tgctcaagaa aagcggttaa tccaagttca attttcgcct gttctttaat 2468701 ggacgctacc tttgcttcgt cacgttttgt ttcctcactg atcacatata gtctgtcata 2468761 ctcggcataa agcgtgtcaa cctcgtcgtc cgtaatgcga tccatcactt caacgagatc 2468821 cccgatgcca tatccgtcaa cctgccagcc aaattgaata tgcgctccca ccttgtctcc 2468881 gtccgttacc gcgacatgac gcatgttatc tccaaatctg gcaaccttaa tatgtctgct 2468941 ttcatttaat gcagccgccg tatccatcca ctgggacatt tcttttttca cttcttcatc 2469001 atcccaatag ccggcaatga cttttcggct aagccccatt ctcgagttga tgtaaccgta 2469061 ctctcgatcg ccatgcgcgg attggttgct gttcataaaa tccatgtcaa tcgtacccca 2469121 cgggatatcg cgattatatt gggtatgcaa atgcataagc ggtttttgat aagaggaaag 2469181 gccttctatc cacatttttg caggggaaaa tgtgtgcatc catgtaatga tgccagcaca 2469241 tgtctcactg tactccgctt ctcttaacag ctctctaatg gtttccggtg aagtgacgac 2469301 gggcttatga gtgattttat atctggaaga aatcccgctg agcccctcac aaatgctttt 2469361 agcatgctga tctacgagtt ccagcgtctc ttccccgtat aggtgctggc ttcctgtcac 2469421 aaaccagaat tcataatcct ttgtctgaag catgtaaact gcccctttct cataaaataa 2469481 aacgctttca aatacaaaag atacgtacta atgatagaaa ataaacctat aaataaatat 2469541 ttgtacgaac aattttatta tagtaattga ctattatact gtcaatcttt tcttttaaaa 2469601 aaagccgggg gcagagcccg gctttttaat tcaataggac ggccagcccg agctccaatt 2469661 caaatcattg atgagaagct ttggaatgcc gttgtcattg gcatcatagg catggcgaac 2469721 aagaatgttt ccgttcacaa tatcctggcc tccaggtcct ttccattggt cattgcccga 2469781 atccaaaatg gtgcctccgc cttcaagcat gctttttccg cttttatcaa gataagggcc 2469841 tgtaatgctt ttggatcttc cgtaagcaat tttgtacgta ctgtttaccc cgtcacagca 2469901 tttatcaaat gaaaccatta aatagtaata tccattttga tacgtaagag taggagcttc 2469961 taaggcacct ccattattcg gtctagctgc aatcgaatag agcgagcctg taggcttcat 2470021 tgtactctta tcgagcttag tcagcttaat gccgctccaa aacgagccga atgcaagcca 2470081 cgggttgcca tccttatcga atgtcagctc cggatcaatg gcgttataat tatttgagct 2470141 tgtcgaacgg atcaccaagc cctcgtcctt ccagcccccc gaactgatgc ttgttgaaga 2470201 tgccaggcca atggcagatg tattgcttcc aaaagaagaa acggaataat atagccagta 2470261 cttgccgtta tagtattgga tgtccggcgc ccactggttt tggccataat tcggcacata 2470321 attggaccac cacgatagcg gtgtagtgaa aatggatttt tgtacggtcc aatttttagc 2470381 gtctgaagac ttcaaaaccc gcagtccccg ttcttcagta agccctgttc cgagcgcata 2470441 ccatgagctc ccctctttaa tcatagtcgg gtcatgaagc agctcattgg atgcacccca 2470501 aaacgctgcc tctgcgggag cagcagaagt gaatatcaaa cctgcagcca gagctgcact 2470561 cgaaaagtgt aagaagcgtt tccatgtttt tttctttttc aattttgttc aacctccttt 2470621 attttagaaa gcgcttacaa attagattat ttatcctccc ttcctgtcaa atcgactgcg 2470681 tatcgtatat cgtcatgttc aggaaatttt cggtatcccc tttattgtag tcactatgct 2470741 gtaatttgta cagacaaaaa aatagaatcc acctcaatag gcggattctt ccgtatcttt 2470801 attggtacgt aatttcgtca accgtttttc ggtctaactt cttaatgact tctgtaatta 2470861 actttaccgc gttttcataa tcatcacgat gcagcatggc cgcgtgcgta tgaatgtagc 2470921 gggttgcaat ggtaatggac agcgcaggaa cgccatttgc cgtcaaatgg atggcacccg 2470981 aatcagttcc gccgccggca atggcatcaa attggtacgg aatgccggct tcctccgcag 2471041 tggctacaac tgcatcgcgc aaacctttgt gagagaccat ggatgcatcg taaacgataa 2471101 tctgcgggcc tttgcccatt ttgctctgcg cttccttctc ggaaatgcca ggcgtgtctc 2471161 ctgctatccc tacatcaaca ccaaacgcaa tatcaggctg aatggtgtgt gcagccgttt 2471221 tcgctcccct cagcccgact tcctcctgca cggttccgac gccatacact atatttggat 2471281 gatctgtgtt ttgtaagttt cttaacacat caatagcaat cgcacagccg atgcggttgt 2471341 cccaggcctt tgcgagtagg aatttttcat tgttcatgac cgtaaattca aaatgcggaa 2471401 cgatcatatc tcccggaagt acaccccact ccaaggcttc ttcccggctt gaagctccaa 2471461 tatcaataaa catgtctttt atttccactg atttttttct tgcttcagga gacaaaatat 2471521 gaggcggctt agatccgata acccctgtga tttctccttt ttttgtgaca atggtgacgc 2471581 gctgagcaag cataacctga gcccaccagc cgccaacggt ttgaaaacgg ataaagcctt 2471641 tatctgtgat ttgtgtcacc ataaagccga cttcatccaa atgtccggcg atcataattt 2471701 tcgggccgtt ttctgcacca gttttttttg caattaaact gcccaggcga tctgttgtca 2471761 cctcatcagc aaatggttct atgtatgatt tcatcacttg ccttacttct ctttcattgc 2471821 ccggtatgcc ttttgcatct gttaaatctt tcagcatggt caatgtttca tctaattttg 2471881 ccatgttcca aaccctcctt catcagtcct gcattcttat tatacaaaac atggcgctaa 2471941 ccatacgact atttcacttg aaaatcgggt atatgttttt acagctttct tttagaaaaa 2472001 gtgaaacctt tttctatgct tttcgtatta catcagatca tcaccataag ggaggtgcct 2472061 tcacacaatg tttgtcatgg ttctaaggat tattttgctt gcactttttg cttattgtat 2472121 ttatgccgtg gtcaaatatg tcgcgaatcc taagagaagg cttaagctgg cccaatcaaa 2472181 agaacatttt tatattattg atgaacaaaa caatacccgg aagaattttc agctgacgta 2472241 taaaggcgtg ctttttgagg gagaaaagca tattccttcc aaggatcatc cgctgtttat 2472301 tcacacgatc tttgtctgga cagaatctcc tgagaagctg aaacatttct ctgcaaaaga 2472361 ttttgagaac attgaagaaa aagtgctgga acgatatcca aattgtaaga ttgactggga 2472421 ccagcccatt aaactcgcaa aaaaagcaga agagcgttaa acgcttttct gctttttata 2472481 aatcaaacgg gctgtagtaa atagcgatga gaatcgcttc tattaccaga agaagcggta 2472541 ctccgtactt aaaagaagcg tgtttcgttt tatgtctgaa ggtttgcatg ccaagccaga 2472601 caccgagcgc tccaaacacg atggctatca gccacagccg gtcttcagaa attctccact 2472661 tgtgctgctg cgctttgcgt ttgtcaatgc ccatcaccca aaaaccgcac agattaatca 2472721 acaccaaata agcagcaata atcatgttgc ctcatccttt atatagaaaa agccgctctg 2472781 ctggagagcg gctctatatg attacttgtt taattgagct ttagcagcat cagcaagctg 2472841 attgaatgca gtaagatcgt ttacagcaag atcagcaagc attttacggt ttacttcgat 2472901 accagaaagc ttaagaccgt gcattaaacg gctgtaagaa aggccgttca tgcgagcagc 2472961 tgcgttgata cgagtgatcc aaagtttacg gaaatcacgt tttttctgac gacggtcacg 2473021 gaaagcatag tttccagatt tcatgacctg ctggttagct actttgtata atgtatgttt 2473081 tgaaccgaaa taaccttttg ctaatttaag aaccttttta cgacgcttac gtgtaacagt 2473141 tccgcctttt actcttggca ttgaatttcc ctcctaattg ttccttatcc gattacttga 2473201 tgttagcaag catttgtttg atacgtttga agtctcctgc gcttacaaca gcactcttgc 2473261 gaagcttacg cttttgcttt tgagatttgt tggcgaataa gtgacttgtg tacgcgtgag 2473321 aacgttttaa cttcccagaa cctgtctttt taaaacgttt agcagatccg cggtgagttt 2473381 tcatttttgg catgggattt cctccttatt gcttttcgtt tttcggtgcg agcattaaga 2473441 acatgctgcg gccgtccatt tttggttttg tttcgactgt cgcaacctca gcacatgctt 2473501 cggagaaacg gtctaataca cgctgaccga tttctttatg agtgattgcg cgtcctttaa 2473561 agcggataga agctttcact ttatcgcctt tttcaaggaa tttaatcgca ttgcgcaatt 2473621 tcgtgttaaa gtcatgctca tcgattgtcg gacttaaccg aacttctttt aagttaatga 2473681 ttttttgatt cttgcgtgct tctttttcct ttttctgctg ctcaaatcgg aacttaccgt 2473741 agtccatgat tcggcagaca ggcggttttg cattcgctgc aactaacaca aggtcaagat 2473801 ttgcgcggcc ggcgatttca agtgcttcct gacgggactt gattccaagc tggtcgccat 2473861 tttgtccgat taaacggacc tcacgtgcac ggataccctc attaaccaat tgatctttgc 2473921 taataatgag ccacctccat agtttcttcg aattgattca caactcattt tgaatgcatt 2473981 ttgcaggcaa acaaaaagtg tgggcattat aaaacaccca cactacgaac atctgtatca 2474041 ataaaaatgt acggtcaacc tgccaactac atgcatgtgt caatcaggtg agaagcgggt 2474101 gcttctgctt gtgatttata ttcaattcaa taactattct acacaatacc ggatctttag 2474161 tcaaggacga cttatccgga acaactttta cattgtaaca tgggttttct atgagcgcaa 2474221 gagagaaaaa gaaaatcttt catccccacc cagaatacaa agaaccaaca attccccctt 2474281 attacgcaat ttacaacaaa accaccgaca ggaagaaatg taaaacaaag ttaatctctg 2474341 accgatataa ggagcagaag ggagcctgac acatgaacaa actgatacag cttgctttat 2474401 ttttcacatt gatgttaacc ggttgctcga atagcagcac atcttccgaa tcaaaagtcg 2474461 aaaccactgt taagacaacg gcagcatttc ctcaaaagga gctggagaaa gagctaaaaa 2474521 aactaaaacc cgtttcattg gacatgaagt tcgagagtcc actcgctacc gagttaggaa 2474581 agcggaaggc aaaagaggaa gctgaaaagc aaagacaaat cgccgctgag aaaaagcttg 2474641 aaaaagagcg ggaggcgaaa cgaaagaaac agcaggagga aaaagcggag agacagcgat 2474701 tagcagagca gcaggctgca gagagacagc gattagccga agcggaaaga caagctgaac 2474761 ttgaaagaca gcggcaggca gcaatccaaa aagagcagaa agcgaacgct gagaaaaagc 2474821 ggcaatcgca ggcacaacgg cagcagactg aggcaccctc atctaatagt caagatccac 2474881 catcttcctc gagtcagaca gataaaacca ttcaacagcc agcttcagag cttcctgatg 2474941 acgatggtta tggttatgaa gaacgaaaaa agtggcatga cgatcaagta gaatggggca 2475001 ttaaacaagg gtatatcgat cccgaagacg caccataaaa taaaaaaagc caaggcattc 2475061 agccttggct tatcctccga tcagctgcac gaacacaggg atgaccagaa ccgttaccac 2475121 tcctactacg acaacagcaa tacttgccat cgcagcttca acttctccca tctcaatccc 2475181 gaccgctaca ccaagtgcat gtccggatgt tccaagagcc aatcctttag aaatcggatt 2475241 tttcacttta aacaccttca agaacaatgc tccgagcgca tatacgatga cagcgttaaa 2475301 gatgaccgca aaggctgtga tgtcgctgat gcccccgatg ccttttgata aaggaagcgc 2475361 aattgccgtt gtagccgcct gcggaagcat gcttttcatt acggccgaat cgagatgaat 2475421 gcctttagcg agcagataaa caatcgtgac agagcagata gagccggcaa taatggaggc 2475481 catgatttgc caccagtact ttttaagctt atctctttgt ttgtacaaag gaattgcaaa 2475541 tgcgatcgtt gccggttcaa gaaaaaactt aatgatctct cccccgttat tataatccgc 2475601 gtaggaaaaa ccgccgattt ttaaaaatgc gatccccagc accatggcaa caaacaaagg 2475661 agtgaaaagg aagaagcctt tcgttttctt aaataaaaag gtgccgatgc cgaatgcagc 2475721 aagtgatacg acaatcccaa aataaggact cattgtgctt tccatgtgaa gaacctcctg 2475781 tttcccttaa tggtgaacga gttcgttatt gttctgcggg ctttgcactg tttttgtttt 2475841 catgtccgct tcggttttgc gttttccgct cagcgacaga atcagctgag aaaacaatcc 2475901 cgtagccccc agcaaaataa tcgttgcgag cagaatgaca agaacaattt gcaggccgta 2475961 ttgctgcatc acaccaagcg aattcataac agatatacct gatggaacaa ataaaaatcc 2476021 gatcagagag gttaaagacg ttccgagcgt ctccacttgt tccagtttaa tgactttcaa 2476081 acataatagg agaaataata agaccaaccc tacaaccgat gccgggatag gtattgggac 2476141 aatagcggca atcatatttg aaaccagcat aatgacggca aaaataaatg cttgtgttaa 2476201 aaacccgtac acttttttag cactcatttt cttcacctct ttctctttgg taccctcatt 2476261 ataaataaga attccctgtt ataaagcgct tacaagataa catgccgtat agcgggtctg 2476321 agttgcagaa tcaaatggct gaaatgcaaa aagccgccca tcaaatatgg agcagctttt 2476381 tcaattcctt cgcatatgtc cggctgaccg gtattttcga tccgtctttc atgatcagat 2476441 tatacgttga attaaaccat ggctgaattt ctttaatata ttcagtattc acgacaaagc 2476501 tccgatggac gcggataaaa tcagaatccg gcagcttttt ctcaatcaca acgagtgtat 2476561 cgctgaccgt ataagaatga tcgaaggttt ttacattgac atgaccatct tctgttccgg 2476621 catagataat gtccttcgta tccacaatca caatcgattc ccccacagat agcgcgagct 2476681 tgtgctggcc ggcatggctg ttttgctctg tttctacaat atcccgattg acttttttat 2476741 attttttcag cgtttgctga attctttctt catcgaaagg cttggttaaa taatcaagag 2476801 cgtccacctc aaacgctttg agcgcatact ggtcatacgc tgtcgcaaac acaatagcag 2476861 gaggatgctt cattttcttc aatcgctttg cgatatcaaa accgttttct ccggataaat 2476921 caacgtctaa aaacagcaaa tcaggttttt gatccatcat ttggtcaaaa gcggattcga 2476981 tattttccgc ttcattgatt tccatttcat cattggtccg cttaagcaag taagccagtt 2477041 catcccttgc cagcatctca tcatcaacta ttaacaccct gagcatgttc ttctccctct 2477101 ttcatctgtt gcattggcac ttgaaaggaa acctctgtcc ctttatgaac ctcactgctg 2477161 atatgcagtg cagcctgctg tccgaataaa ccgatcagcc gctgatttag gttataaagc 2477221 gctgtaccgg ttccctcctt agacggaaac ggtttcttcc ccagttccgg caagacgtcc 2477281 ggcggaattc cgcgtccgtt atccgccacc ttcatataga cggatgcatc atcagataag 2477341 acacagactg taaccttgca tatgtcttgt tttttcggaa acgcgtgccg aagcgcgttc 2477401 tcgacaagca cctgcaaaac aaacggaggg atttcaatct gctccagtct gctgtcgata 2477461 ttaagctcaa ttttatattt cccgggaaaa cgcgcctgtt ctaatgacaa ataggcgtta 2477521 agatggttca gctcctttga gagcggaatc agcagctgtc tcgctccttg aaggtttgaa 2477581 cgaaaataaa cactgagctg caataggagc ttacgggttt tttcaacatc tgtacggcat 2477641 aacgcagaaa tcgtgttgat cgcattaaat aaaaaatgcg gattcacctg tgcttgaagc 2477701 gctttaattt cagcatcctt gagaagtttg ctttgcagct ctgcttcccc aagctcaagc 2477761 tgtgtcgaaa acagcatggc cagcccctcg gcaagttcct cctctacctg actcaggcct 2477821 gccgggcttt taaagtacat ttttaaggtg ccgattgtat tgccgttcga tgtcagcggt 2477881 aggacaattg cagcgtgcaa agggcattca gcatgcgtgc attcaatctc ttcctgcgaa 2477941 atcgccttca taatatgccc tgttttaatc acctttttgg acaggccggt gatcaagctt 2478001 ttcgatggga tgtggtgatc cattcccgca ccgacatgcg caaggatctt ttctttgtca 2478061 gtgagagaca ccgcatctgt tcctgtcagc ttatggataa tagccgctac acttttacag 2478121 gagttttcat ttaatccttg gcggaaaaat ggaagtgtct gatcagcaat cgtaagcact 2478181 cgatgcgttt cgagagccct tgcctgttct tccttgcgaa tgatcgcttg aataatagac 2478241 agaaaaataa aactgcctgt tccattgatg agtatcatcg gaattccgat catgctgaca 2478301 agctcccaag cgtcactgaa cggctttgcc atcagcaaaa taatgatcat ttgcagtgac 2478361 tccatgccga ttcccacaag agcggcgatg cgcggtgtcg gcattcgata tcgcttcgta 2478421 aaatacctgc cgatcaagcc tgcaagaaca cccgctaaaa tagatgagac ggcacagctt 2478481 aaggccgtgc tgccaccgag tgaaaaacga tgcaggcccg caagtatgcc gatcccagcc 2478541 cctacaaaag gacctccgag aaggcccccg atttccacgc ccaaaatacg ggtattcgcg 2478601 atagagcccg atggatctat cgtaaacacc cagtcattgt ttacaatcat atttctttga 2478661 atttcgatgc ctgtataatt gctgatgatg ctgaaaagag aaaaaataga aattaaaatc 2478721 gcttttcctt tatagccgtc ctgattctga agagcttgtc tgaaaagttt cgtatgggcg 2478781 agaatgaacc ctaatataac aataatcccc actctctcca gcatcataat cattaaatga 2478841 atcattcatg tcacctgttc tttccgtttt cattctagca tgttttcgtt ttgcggctga 2478901 ctgttttttt aaaatcgtct gaaaacatat ttcacaaggc ttttatctat tgtaaaataa 2478961 aacatgagcc ttttggcaga aagatttgaa tctgaagcag aggagaagat catgaaagcc 2479021 gtattttttg atttagatga tacactactt tgggacgaaa aaagcgtcag aacaacattt 2479081 gcagaaactt gcttacaggc ggagaaaaaa tatggccttg cccctgagga attcgaagca 2479141 gctgttcgcg aagcggcgag agaattgtac atgtcatatg agacgtatcc atatacagtg 2479201 atgatcggca ttaacccgtt tgaaggactg tggtccaatt tctcagagcc aatcagtgaa 2479261 ggctttcaaa agctgaacaa gattgtgccg gagtacagaa gaaatgcatg gaccaacgga 2479321 ctgaaagcgc ttgggatcga tgatcctgca tatggcgaat acttgggaga gttttttgcg 2479381 gcagagcgca gaaagcgccc gtttgtatat gatgaaactt ttgctgtact cgatcaatta 2479441 aaaggcaagt atgaattatt gcttttgaca aatggcgatc ctagtctgca aaaggagaag 2479501 cttgccggcg tgcctgagct cgctccttac ttcaatgaaa tcgtcatctc gggcgcattc 2479561 ggcaagggca agccggatgt ttcaattttt gaacactgcc ttaagctgat gaatattgaa 2479621 aaagacgatg ccatcatggt cggcgataat ttgaatactg atattttagg cgcttcaaga 2479681 gccggaatca aaaccgtttg gatcaaccgg actgataaga aaaacgaaac tgacgtaaag 2479741 cctgattaca tcatcagcag ccttcatgat ttgtttccta tattagagaa ataaaaaaag 2479801 catgatctct tcaatgagat catgcttttt tattttattt tttcgcttca gctactgcct 2479861 ttttcacaaa ctcatcaagt gaaatggttt cagagttctg ttctccgtat ttacgcacgt 2479921 ttaccgctcc gttttctgct tcttggtcac cgaccaccag catgtacggg attttttgca 2479981 tttgcgcttc acggattttg tagccgattt tttcatcgcg gctgtcgact tcaacacgca 2480041 ggccttcaca ttgcaggcgt tcctgcactt ttttcgcgta gtctaaatgc acagccggag 2480101 aaaccgggat gacttggaac tgaaccggtg caagccatgt cggcagcgcg cctttgtgtt 2480161 cttcgattaa gaaagcaaca aagcgttcca ttgttgaaac gacacctctg tgaatgacaa 2480221 ccggacggtg ctgcttgccg tcctcaccga tgtatgtcag gtcgaaacgt tccggcaata 2480281 agaaatcaag ctgaaccgta gacagtgttt cttcttttcc gatcgcagtt ttcacctgaa 2480341 catcaagttt aggtccgtag aatgccgctt caccttctgc ttcgtaatag tcgtggccga 2480401 tttcatccat tgcctctttc agcatggatt gcgctttgtt ccacatttca tcgtcatcaa 2480461 aatatttctc tgtatcttcc ggatcgcggt aagacagacg gaatgtgtaa tcacttaaac 2480521 cgaagtcttc ataaacatcc tggattaaac ggactgtacg gataaactca tccttaattt 2480581 gatccgggcg cacaaagatg tgtgcatcat ttaacgtcat tccgcgtacc cgttgaagtc 2480641 ctgacagcgc acctgacatt tcatagcggt gcatcgttcc aagctctgca atacgaatcg 2480701 gaagctcgcg gtaactgtga atgtcttgtt tgtaaatcat catatggtgc ggacagttca 2480761 tcggacgcaa tacaagtgtt tcattgtcca tttccatcgg agggaacatg ccttcctgat 2480821 aatgatccca gtgtcctgat gtttcataca gctctttgct gcctagcaca ggtgtgtata 2480881 cgtgctcata gccgaggctg atttctttat cgacaatgta gcgctcgatg acgcggcgga 2480941 ttgttgcgcc ttttggcagc caaagcggca ggccttgtcc gactttttga gagttcgcga 2481001 acagctttaa ttctttgcca agctttctgt ggtcgcgttc tttcgcttct tctagcatac 2481061 gaagatgctc ttcaagatca gcttttttga agaaagctgt accatatacg cgctgaagca 2481121 tttggttttt gctgtcaccg cgccagtatg cgcctgcaag gcttaacagc ttaaattctt 2481181 tgatttttcc ggttgaagga acatggacgc cgcggcacag gtcaaagaat tcgccttgct 2481241 catagatcga aacggtttct ccttcaggaa tcgcatccaa tagttcaagc ttcaggtcgt 2481301 cgccgatttc cgcaaaacgg gctttcgctt cttcacggct gacttctttt cgaacgatcg 2481361 gaaggttcgc attaacgatt tttttcattt ctttctcgat tttcggcaga tcctccggtg 2481421 taatcgcttc gtccatttct acatcgtagt aaaaaccgtt ttcgataacc ggaccgacgc 2481481 cgaatttaac atccttgtag atgcgtttaa tcgcttgagc cagcaagtga gccgcactgt 2481541 ggcgcataat ttgaagacct tcttctgagc cttctgtaat gatttccact gtaccgtctt 2481601 cattgatcgg cgttctcaaa tcgatttctt ttccgttcag ttttccggct aatgactttt 2481661 tctttaatcc cggactgatg gatgccgcga tatcttctgt tgttgttcct ttcgcaaact 2481721 ccttgactgc tccatcagga aatgtgattt ttaccatatc tgacatcttt gtcactcctt 2481781 tttttgcata taaaaacccc gccccctatg aaagggacga ggttgaataa acggaatcgt 2481841 ggttccaccc ttttttccgc aaagccaata cacggcacct gcggctctaa gctctgtaac 2481901 gggagttccc gtcagccatt actgttcctt ttcaagaggt tcacagctga agttcaaagg 2481961 cggtaaagcg aatggtcctt agctgggaag cttgcagcca gggcttccct ctctttgagc 2482021 cggtatcatt ccttcgtgtc cttatcaata cgtgtgtctt tcttaatctc ctatgtatta 2482081 taaattgttc aatccaaaaa atcaacacga tcgcgtttcc ttttttttaa accgacagcc 2482141 ttaaatagac aggctgccgg ccctcatcct tccgagtgct tcaccggtat ttctgcatct 2482201 gtaaaagcat gcagcgggag catttccact ctctcttgaa atacgttttg aatggtcctt 2482261 gccatcatgt gctcgggctg gtcggtataa agcacgactt catcaggcgc aatggaaatc 2482321 agcggcgcga gcaaatgaga atcaatatac ataggatgat cccggacaaa tcttctgtct 2482381 atgtatttca ttttttcccg ttccggcaca tagcgcagct cccataatgt aaaggaacca 2482441 tcatggacaa tatgcacttt tttgattcgc ggctgtttgg cgtccacata gtctctgagt 2482501 gtttgaataa agttttgata ttcctgttcc atcttatatt catcaatcgc tgcttctgta 2482561 atatctctca gctgcttata gtatgatcca agtcggaagg tctgaaagga gcgaatgtaa 2482621 aatactcctt cctctaaaca gatcgtttgg agttcatcca aaattgattg tttccgtgaa 2482681 agcttcagcg gctcaaacgg aagatcgtct gcttcacctt caataatact gtgtgcgagc 2482741 tgaaggattt gctgctgttc atcctggtcc gtgaaacaat acgtttcctc aatcaatgac 2482801 agcatatgct cgtcttcttt gcattccaaa aaaaatttga ccagaatcgg ctccataaaa 2482861 cgctgaatag gaaaagccgg attcgctttt tcaatcccga tttttcgtat gccttcacgg 2482921 acaatgatat tgttccgatc gtccgaatgc tgaatgagat gtaaaaaagc ggctgcatca 2482981 tggtcatctt caaagattat ttcaagcatg tttgtccccc cttacggcat ctgttacaag 2483041 tatatggggg atgtttttaa aatagacgta aaggtcattg gcaaatctta atttgattct 2483101 tggaacaagt tttgcatttt ctttctgaag atgaacggca atgagataaa cacgatatac 2483161 aaagcgagca ccataaagaa agcgggcaga ttgccagcca aaaagctcgc acccagcaca 2483221 ttaagcgcaa tcgtcccagg gatgattccc acagccgttg cggcaaaata cggcagcgct 2483281 ttgacattgg aaaggcctgc cgcatagctg acgaaatcaa aattgatcgg caggattctc 2483341 aaaagaaaga tatagaaaaa tccgttatcc tccatttgct tctgtatggc ttcaagcctt 2483401 tcgtaatgcc cgttcttttt cgccgaaaac aaaccagccg caaaaaacga aacagctgaa 2483461 gcgcacatcg aaccgaataa cgtataaagc gtgccgagaa gcgggccaaa cgcaagtccg 2483521 ccagctattg aaataacaga caccggaaat aaaacaagtg gcctgacgat ggatatcccg 2483581 ataaacatca gaggtgcaaa gactccgaac gacaataccc ataccctgat ttctttcggc 2483641 gatacattca aatacgtttt atttccccaa tagagtaaac cagcacctgc aagcactgcc 2483701 agccatttga cagccgtttt tcgtttcata ccctcagttc cttccccttt gaaccacagc 2483761 aattatggat gtcggcggtt ttctccgtca aggcggatcg gagcagccaa atataatatc 2483821 cgctccatta atcttgcagc ttttacttct tctttttctc ccctctgcga atacgtaaaa 2483881 tgatgcttca gctcgtcagg tgagaaatta gaagaaaaga acgttggcag ctgctgggac 2483941 attctgtgct gaagcaccgt tccgatgacc tcatccctta cccagcttgt cattgattct 2484001 gctccgatgt catcaagcat taatacgggt gtggtcttta ccatattgag cttctcttcc 2484061 aatgtctggt cttgcagcga attcttaagc tctctcacaa attcaggcac ataaacaatc 2484121 atggaggaat actctttttc cgccagctca ttggcaattg cagcgagcat aaacgttttt 2484181 cctaccccaa atttcccgta taaatataat cctttccctt ttcccgtctc attatagctt 2484241 ttcaggaagt ctgtaacatg ctgaaacatc gcgagtctgc ttgggtcact gatatcaact 2484301 tgctggaacg tcgctccaag aagatcctgc tggatataca tgcttttcat aagagactgt 2484361 tgtttcttct gctggtcgag cttccgtttg actggacatt cgtaatactc gatatcaata 2484421 gacctcccat tgacaacaag cttcggatgg tagccctcca acaaattgtt gcagttttca 2484481 tcttccgaac aataggagca attcttgctt tgttcgatat attcataaag cttatttaag 2484541 ctcttttcga tcattttttg gtcaatcact tcttcgtttt ccttcaaaaa tgcttgaaca 2484601 tcttgatctt tcatgacttt ttccttcatt tgttcaagac gtttttggaa atccggcctg 2484661 ccggttacgc cctgcaggga acggccgatt ggttccatct attccttcac cccgcatctc 2484721 tgtctttaat aggcagagta ttttttcagt ttttgcattt cttccatcat ctttttcttc 2484781 tgttcttcca aatcctgcgg atgcagcttc tgctgtccgg attctgaatc ggacgctgtt 2484841 tccttttctg tcatccaatc aggaagcttt tcttcacgaa tcactttttg gtttcgtttc 2484901 gaagactttg tttttccctc agcccattca agatactggc ggttttcttc tattgcgagc 2484961 ttcatcgctt ccctgaccgt tttcaccttt ttgcgtgccc aatgcgaagc gattttttgg 2485021 atatagtttt tcgacagctt catgtcggtt ttcagcatga cataataaat taacacattt 2485081 gtgacgcctg gctcgagctt ctgttcgaac ataatttctt ctatgatctt cagatcagct 2485141 tttgacggct ctgttccgtc agcaatgtcc tgcagaagct tcttcgggga aatcgcctcc 2485201 agcaatgcaa tcagcttccc atccagagaa tcctcttctg ccggttgttc gccttcacgc 2485261 agatgcaccg gctgtgtttt ttccaccaaa tcgggcagct gtccgtttct ttcaatttga 2485321 taccagtcgc tcgccgcttt tcttaatgcc tccgtcgtaa tgacgtcacg ctcatcaatt 2485381 gcgctcatca caacattttg catttgcaaa gggtcaattc cgtacagata agaaagcttt 2485441 ttgattgtgt cccgcacctg ctgggtcatc gcttttctcg gtatcatcgt ctcagaaagt 2485501 cccgctaaaa acaaatcaaa atcaaacaca tcctccgtta tggtgtagga cggagactgt 2485561 ccgacagaag tatactcgga cccctcggca agccttaccg tttcctccat atcggatgtg 2485621 agcttccatt cactcggctg cagcgattca aacgcatgat taaacggacg cgtaatgtcc 2485681 ttcgcatctt ctgaaatggc cgggtgcgta aaaaattgtt ttaattgctg atatttcgtt 2485741 tttccgaccc tattatacag aaaaacattc agcattccgt cttcaaaaaa ttcatttggt 2485801 ctgagcggcg gaaggagttc atatataaag aggcgctcct gccgctcgga ttctttcata 2485861 tatactttca gcaatccgat gccctcgagc ttcccctgtt cctgatggat cgtttttaag 2485921 ttggactgtg tcatccccat cagctgtcta tgtgtggact ctccgcccca cagacggttt 2485981 tgttcaagct ctccccacaa tgtcatataa agagagaatg caacagggcc gattaagggc 2486041 tggtacagtt gtgtaataat ttgtctgtca atatcctgca gcatcgatct gcttttaacc 2486101 acatacgggt ctacaggcag tacatctttc caatagtcag ccatacattc tcaaaccttc 2486161 cgaatttgtt tctacctttc attttacacc gtttcttata tctatcaaat gccaattttg 2486221 cacatgagaa aagagctaga agaatcctct tagctctttt aacgctcttt ctttattaag 2486281 tcttttaatt catcgataaa gacgtttata tctttaaact gccgatagac ggacgcgaac 2486341 cgcacatatg cgacttcgtc aatcttagcc agccggtcca tgaccatttc tccgacgagc 2486401 tcactcttca cctcggagca gccttgattg cgaagttctt tttcaatatc aaagcacatg 2486461 tcttcaagcg ttttgagtga aacaggcctt ttttcacatg cttttatgag gccgcgcagc 2486521 attttttctc tgctgaattc ctcacgcaca ccttcttttt tcacaacgat gagcggggtt 2486581 tcctccactt tctcaaaggt cgtaaaccgg tagtggcagg attcgcactc gcgtcttcgg 2486641 cgaatcgact ttccgtcatc cacaggccgt gaatcaagga ctcgtgttcc gttatgctgg 2486701 catgaaggac atttcaataa aatcagctcc caactatatc gttccctgca atgtattttc 2486761 ggcagcctcc gccttttaaa aatagatgtg acagcatctg tcgggagagc cgttgttaaa 2486821 tttgtttcta tagcattagg tggtttgtga aaatctcctt cttattttac aaaaaaaatg 2486881 aaaaaagaaa aagctgacac tctcgtttct ttataaaaat aaaaggagca taagctaaaa 2486941 agcgcataat ggctttctag cttcagctcc ctttgtgttc gcaatttact ttatagtact 2487001 ttcgcttgcg cctgtttaat ttgcacaggc cccattcctc ttggtatttc aatgttttct 2487061 cttgtatcag catgtaatgc ctctgcaatg taatcagcag cgacattagg atctaagtct 2487121 ccacaagtat aaacatcaat gctcgcatat ccgtgctcag gaaaactgtg aatcgttaag 2487181 tgtgattcag aaataatcac aactccgctt acgccttgcg gtgcaaattt gtgaaatgca 2487241 acctcgcgca cctcagcacc tgattttaga gcagcattta caaacgtttt ttcaataaaa 2487301 tccatgtcat tcagcttatc aaaatcgcat ccccatagct cggagataac gtgacgcccc 2487361 attgtttcca tagtcatgga ccccccttaa caagaattaa aaagtgaaat tccaacaact 2487421 gggtcggcca tttaccacgg gggaaagtta gtccggagag gtcctaaccc tttaagtaat 2487481 tccgaaacag tctcaagcaa gaagttcacg aaaaatagta tactgtgttt aagtctaatt 2487541 tgcaaggtgc gttttttcag aaatatgctg ttaagggttt tttctttaaa atgtgtccat 2487601 gaccttattt tatacagcag acggatgttt cattcgtgcc gctacatggc ggattagatc 2487661 aacaactctg caggagtagc cccattcgtt gtcataccac gccagcacct ttactttcct 2487721 gtcttccatt accattgttg taagcccgtc aatgaccgct gaatgcggat tcgtattata 2487781 atcagtcgaa acgagcggtt catctgagta atcaagtaca ccgtacatcg acgttttggc 2487841 agcgcgttta aatgcctcgt ttacttcttc agccgtaaca tccgttttca gatcaacaac 2487901 gagatcaacc aatgagacgt tcggaacagg gacacgcaag gcgaggccgt gaagttttcc 2487961 tttcagatgc ggcagcacaa gcgaaagcgc ctttgccgct cctgttgttg ttggaatgat 2488021 ggattcaccg caagcccgcg cccggcgcaa atctttgtgc gggttatcaa tatttttttg 2488081 gtcattcgta tacgcatgaa ctgtagtcat cagaccgctc tcaatgccaa actcttcatc 2488141 cagcactttt acaacaggcg caaggcaatt tgtcgtgcat gacgcatttg aaataatgac 2488201 atggcgctca gcgtcgaatt ggtcctcatt tacgcccatc acaatggtaa cgtcttcatt 2488261 ttttcccgga gcggtcaaaa tcactttttt tgcacctgct tctatatggc ccatcgcttt 2488321 atctttagca ttaaacttcc ctgttgcttc gacgactatg tcaatatcat attcccgcca 2488381 aggcagctgt tttggatcac ggctgtttaa caaaagcact ttctttccat ttacgatcag 2488441 gctatcttca ccagccacaa cctctttgtc gtatctgccg tgaattgtgt catactttat 2488501 taaatgagcc agcgtttctg cggaatagct ggcgttaatg gccactactt gaatttgatc 2488561 gtctaacatc gcttttctaa aaaccattct tccgattctt ccaaacccgt tgatcgctac 2488621 ttttaccttc atgttggaca ccccttatca attatgccat cctaatttgt tactatctaa 2488681 aattagtata acacattaaa acaaattcgc cagtacatat tgataaaaat caacgattat 2488741 aacgctaatt tatgatgcat cttatgtttt cttgcacaga atatcaggcg taagaaccaa 2488801 aaagcagcca gcgctccgca ctgactgccc tcatgcttta tgattcctgt tttaacttat 2488861 cattgagcac actttcttct agcacagaaa atgtatcccc gtacactctg ttaatatgat 2488921 tcgctcccca agcacacagc atatctaaaa tcccttctaa gctgcggccg tattcgctga 2488981 gctcgtattc cactttggga ggaacttgat tatatacgat tcggttaatg acaccgtccg 2489041 cttccagctc gcgcagctgc tgagtcagca ttttttgcgt gatattgggc attaggcgtt 2489101 ttaattcact tgtgcgtttt tttccgtgcg tcagatggca taaaatgacg catttccatt 2489161 tcccaccgat cacttcaaga gtcgcttcaa cagaaatgtt atattttttc ttctccatac 2489221 aatccattct cctcacaggc accaaaaagt gactatagca cttcaaagta cgtactttta 2489281 tttcttaacg atatgtttca taatcacatt tgccggctga tttgaatctg ctctttttta 2489341 tttatatagc ttactcggca gaatttcaat catacaacac atcttacaaa ggaggaacat 2489401 catgacttca gccaataaaa gcaatattcc tgcactactg gctttggccg taagtgcatt 2489461 cgcaataggg acaactgaat ttatcagtgt cggccttttg ccgctcattg ctgatgacct 2489521 ggatattccc gtcacgacag caggattgac cgtttccctt tatgcgctcg gcgttacatt 2489581 tggggcacct atattaactt cattgacctc aagcatgtca cgtaagacac tattgctttg 2489641 gatcatgttt atttttattg ccggtaatac gatggcagca accgcttcaa gcatcgggat 2489701 tttactagca gcacgtgtga tatcggcatt ttcgcacggt gtgtttatgt cgatcggttc 2489761 gacaatcgca gcggatattg tcccggagga taaaagggct agcgcgattt caattatgtt 2489821 tactggcctc actgtggcaa ctgtaaccgg agttcctttt gggacattta tcggccagca 2489881 gttcggctgg cgtttcgcct ttatggtcat tatcgccgtc ggaatcattg ctttcattac 2489941 aaatggcatt cttgtaccgt ccaaattacg aaaagggacg aaaacaacga tgcgggatca 2490001 attgaagctt gtgacaaaca gccggttatt gcttttattt gtcattacag cgcttggata 2490061 cggaggaaca ttcgttgtgt tcacgtatct gtctcccctg cttcaggaag taacaggctt 2490121 caaagccggg actgttgcag tgattctgct cggatacgga atagctattg ctatcggcaa 2490181 tatgattggc ggaaagctgt caaaccgaaa tccgattgcc gctttattct atatgtttat 2490241 cgtacaggca atcgttctat tcgtactgac atttacagcc ccgtatcaag cagcagggct 2490301 cattaccatt ctctgtatgg gattgctggc ctttatgaac gtgcccggcc ttcaggtgta 2490361 tgtcgtcatg ctggctgagc gttttgtccc gagtgcagtt gacgtcgcat ccgcgatgaa 2490421 tatcgctgcc tttaatgcag ggatcgcgct tgggtcatac cttggcggtg tgatcaccga 2490481 ttcaatcgga ttgattcata ccgcttggat aggcggatta atggtggtcg gtgcagtcat 2490541 tttaacaggc tggagccgct tgatggaaaa acgagatcgg caggaagcct gacaatttta 2490601 aaggaggaaa taaacatgac aacacattta caagcaaaag caacacttca taatggggta 2490661 gaaatgcctt ggttcggcct cggcgtgttc caagtggaag aaggatctga actggtaaac 2490721 gcagttaaaa ctgccattgt tcacgggtac cgcagtattg atactgcagc aatctatgga 2490781 aatgaagctg gagtcggaga agggattcgg gaaggcattg aagaagcagg catttcaaga 2490841 gaggatctgt ttatcacatc gaaagtatgg aatgcggatt taggctacga agaaacactc 2490901 gccgcgtttg aaacaagtct gtccaaactc ggtctggatt atttggatct atacctcatc 2490961 cactggcctg tagaaggaaa gtataaagaa gcttggagag cgcttgaaac gctgtataaa 2491021 gaaggccgta tcaaagcgat tggcgtaagc aacttccaaa ttcaccatct tgaagatctg 2491081 atgacggcag ctgaaattaa gcctatgatt aaccaagtgg aatttcaccc gcgcctcaca 2491141 caaaaagagt tgataagata ctgccaaaat cagggcatcc agatggaggc ttggtcacct 2491201 ttaatgcagg gacagctgct ggatcaccct gtattggctg acatcgctca aacatataat 2491261 aaatctgtcg cacaaattat tttgcgctgg gatctgcagc atggcattat aacgattcct 2491321 aaatcaacga aggaacaccg cattaaagaa aatgcaagcg tatttgactt tgaattaacg 2491381 caggatgaca tgaaccgaat cgatgcactg aatgaaaact tgcgcgtcgg tcctgatccg 2491441 gacaactttg atttttaatg gccaaaaaac accgttcaat atgaacggtg ttttttgtat 2491501 tatgcccagc tgttcatgat ttcatcaagc tgccttttgg tctcttcaag cgtgccgctg 2491561 ttatcaatga cttgatctgc tcttgctgtt ttttcctcta agggcatttg agagcggata 2491621 cggctgactg cttcttcttc tgtcagctga ttgcgcttca tcagacgttc cagttgaagc 2491681 tcttttgtca cactgaccac aataatttta tcaaccaatg attccaattt gctttcgaac 2491741 aatagcggga tatccaatac aacaaatgcc tcccgatttg caacggcttc atcacggcga 2491801 ttgagcattt cctgcctgac tgcgggatga acaattgcat ttaaagcgag acgtttttgt 2491861 tcatttgtaa ataccagcgc tccaagcttt tttctatcta tatcgccatt tgagagcagt 2491921 atgtcttcac cgaattcgtc aatgatttgc cggtaggccg gcatcccttt ttctaccgct 2491981 tgttttgcaa tgatatctgc atctataact gttattcctt tttcaatcag catattggct 2492041 accgtgcttt tgccgctagc tattcctccc gttaaaccaa tgactaaggt caagagatcc 2492101 actccttttt acaatttcca gagcccaatc gtgattaata gaagccccgg caaaaacgcc 2492161 attttatcga tccatttcca cttagacaga aaatggccgg cattgattcc aattgataca 2492221 aacagcgagc tcatgattgc cacggcgatg ctcatcacaa tcggcgaaaa accgagaatg 2492281 gctgcgccta tacctgctcc aaaggcatca atcgataagg caaatcccaa taagaccgcc 2492341 tcaattccgt tgatcacacc cgatttgtcg atatccgcac tcatgggttt tctcaaaata 2492401 tgaatcacaa ttcctaatga ccgaacctct agattaagca gtgttttttc atgcaatagg 2492461 tattctttat cttttgccgg tttgaaaaat tgatacagaa cccacgcacc gattccaacc 2492521 aatatcaaac cgccaagctt ctccgtcaca tatacaggaa aaaacttcgt gagaaagctt 2492581 ccgatcagca tggatataaa catgacagca ccggaacagc aggcgataac caaaatcgct 2492641 ttaaacggta ttttcatttt tctcaatccg tacgtaaatc cgactgaaaa actgtccaag 2492701 ctgacagcca acgccagcag cagtatagaa accatttgca tatccgtttc ttcctttctg 2492761 ttggtgctct tgtatcagat gtgaaatgcc cgggattcat cacaatcata tatatgggaa 2492821 agtgaaaaat ccgtgtttcg aaaatggcat ccttaatcca gagttactga tatatgcacc 2492881 gacagcttgg acaatgaagc attatgctac ttttttgtct ggcactttgc gcaaaaatgc 2492941 gtgcctcttc ctccaacgac aattttcgaa atcatcgttc cgcaattttt gcatggctcg 2493001 tctttttttc cgtacacaaa atgctgcagc tggaacattc cgatttcccc ttgggagttg 2493061 atatatgaac ggactgtgct tccgcccgca tcaatcgcct cctgcagagt gtttttgatt 2493121 tcagcgtgaa gggttttgat tgttttatct gataattgat ttgcttttgt ctcgggatgg 2493181 acacccgctc tgaaaagagc ctcatccaca taaatgttcc cgagtccaac taccgttttt 2493241 tgatccagta gggcagtttt gacagcgcgg tttgttttcg caagccggtc ttttaaatac 2493301 gcacttgtaa attcttctgc atccggctcc ggccctaact gagaaagcgg gagctcgccc 2493361 gcttcttctc ccggtttaaa taagtgcatg gttccaaatt tccgcacatc cctgtaccgg 2493421 agctgggttc catccgtcat cgtgaatatg acatgcacgt gtttatcgtc aggctcctcg 2493481 gcttgatgaa gaccgtattt tccttccatt cgaaggtgag aaaccataac ataatgatct 2493541 aaatgaaaca gtaaaaactt tccccgtctt ccgatggact gtatcgtttc tcctgctagt 2493601 tttcgcgcaa attcctccgg ttcggcaggc cgtttgatga tattcggcca tctgatctct 2493661 accgatttga ttgtttttcc ctttacaagc ccggtcagag tgcgccggac cgtctcaacc 2493721 tctggtaatt ccggcacatc catcacttcc tatctctgtt tatttcgcat cgtaccaaga 2493781 tgggcctgat gcaaagtcca cctttaacgg cacatctaat gcaagcgcat gctccatcac 2493841 ttcaggaaca agcttttcaa gaatttcaat ttcttccttt ggcgcctcaa aaatcaattc 2493901 atcgtgtact tgaagcagaa gccttgcttt caactgtttt tctttcagct tggcagccat 2493961 gtcaatcatg gcttttttga taatatcagc ggcgcttcct tgaatcggcg tattcatggc 2494021 cgtccgctcc gcaaaacttc ggatattaaa gttccggctc gtcagctcag ggatgtagcg 2494081 gcggcgatgc ataagcgttg ttacgtatcc tttttgtttc gcttcctgta ctgaatcttc 2494141 catgtacgct tttacgcctt ggaagctttc cagatagcgg tcgataaatg ctcccgcttc 2494201 cttccgggta atgccgaggt tctgtgacag accgtaatcg ctgatcccgt aaacaatgcc 2494261 aaagttgacc gctttcgcct ggcgtctcat cgcagatgtc acttcatcct tagcgacatg 2494321 gaacacatcc attgccgttt tcgtgtgaat atccatatca ttagtaaaag cttcgatcag 2494381 attttcatcc tttgaaatat gggcaagcac ccgcagctcg atttgtgaat aatcggctgc 2494441 aaaaatgagc cagtcttttt cagacggcac aaaagcttgg cgaattttcc gcccttcctc 2494501 aagcctgatc ggaatgtttt gcaggttcgg atcagtcgag ctgagacggc cagtttgcgt 2494561 taaggcctgg ttaaatcgcg tgtgcacttt atgcgaatcc ggtctcgtca cctttaaaag 2494621 cccttcgata tatgttgatt gaagcttgcc aatttgtctg tactgtaaaa tatagtcgac 2494681 aatatcatgc ttgtcagcca gcttttcaag cacatcggca gacgtagaat agcctgtttt 2494741 cgttttcttt acgacaggaa ggccgatctt ttcaaataag atgacgccta gctgtttcgg 2494801 agaattgatg ttaaacggct ctcccgcaat ctcatggatt ttttcttcat attccttcag 2494861 cttcgcaccc agttcttcac ccatccgttt taaacggtca acatcgacct tgacgccagt 2494921 tgattccatt tcgccaagaa taagcgcaag aggcatttcc agctcttcaa acagttcaag 2494981 ctggtcgttg ttttccagct cttgaacgag cttttcccga aggctttgaa tcgctaacgc 2495041 ttttcggcca aggtgctcag acagtacgtc ttctgacggc actgcccgtt ttgctccttt 2495101 tccataaact gattcatcac ttgaaacgat atgcaggccg taatccttag ccacactcgc 2495161 aacgtcgtca tatgaattgc ccgggttgat gatataagcc gcaaggagcg tatcaaactc 2495221 ggctcctttc agctcaatgc cctgccagcg caaagcgaca acggcccgct tgctgtcgaa 2495281 gacccatttc ttctgctcgt cattttccac ccattcttta aacacctcag actcaacggc 2495341 aatgtctttc ggaatgaaat aagctcccgt ttcatttacg atcgaaaatc cgaggatcgg 2495401 ctcttcatga taattatcgc caatctgttc aacgacaaat gcggatggag aaaccaatat 2495461 atcgcttgtc acgtctgtga ctgttttgac attaatgtct tccaacgatt gatcctgttc 2495521 tgcttctgca ctgtcttctc caagccgttc aagaagcgtg ttgaagccaa gatctttaaa 2495581 gatggcaatg acctgttcac gattaaagcc ttgatattcc aggccggaaa cagatacctc 2495641 aatcggagca tccgtcataa ttgtcgcaag ctccttgctc atcaatgcct gatccttaaa 2495701 ctcctcaagc ttttccttca atttctttcc gctcacctcg tcaatggact ccagcagctt 2495761 ttcaacggaa tcaaattgtt ttaaaagctt aatcgcagtc ttttctccga cgccgggcac 2495821 acccggaata ttatctgagg aatcgcccat cagacccttc atgtcaatga tttgttcagg 2495881 cgtaagccca tatttctctt tgacatgctc cggtgtgtaa aattcaacat cggtaattcc 2495941 ctttctcgta atggcaactg tcgttttgtc cgttgccagc tgggttaaat ccttatctcc 2496001 tgagaaaacc ttaacttcaa atccgtcttt ttcagccgat ttggccagtg tgccgataat 2496061 atcatccgct tcatattgtt ccagttcata gcggctgatc tggtaggcat ccagcagctc 2496121 gcggataaac ggcatttgtt cggaaagctc aggcggggtt ttctgtctgc cgcctttata 2496181 ttctttaaat gtgccgtgac gaaatgttgt tttcccggca tcaaacgcaa ccagcatgtg 2496241 cgtcggtttt tcatcctcaa gcattttcat caaaatcatc gcaaagccgt atacagcatt 2496301 cgtatgaaca cctttatcat tgcttaacag cggcaatgca aaaaacgccc ggtaagccag 2496361 actgtttccg tctacaagca ctaatttttt tcgttccgtc attcaatttc ctcctaagaa 2496421 gcctcaggct tccattcatc tcttacatag tcattagctc ctcttatttt aacaaagttc 2496481 aatttgaaag gaaaatacgt gaactataag agaagacaca aaaaaggacg ggaacacaaa 2496541 taggttcccg ccgtcaaaat tggctccttg gatgaagggg ttctactaca tcctaccagc 2496601 ataggtttaa cagtgcatga agatattgtt aaacctttgt aaacattagg cggacttttc 2496661 agcggcccgt ttcagcgtca cggtaaagac agttccccgt ccaagctcgc ttgtgacatc 2496721 aattttccct tcatgagcct ctattaaatg cttgacaatc gctaggccca gcccggttcc 2496781 gcccgaattt ctgcttctgt ctttatctac acggtaaaag cgttcaaaga tgcgcggaat 2496841 ttcttctttc tgaattccga ttccagaatc ggcaacctca atctgaatgt ctttttctct 2496901 gggctttaca ttgatagcca cggagccccc ctcaggcgtg taggttaatg cattgtttac 2496961 gagattaaga aatacctgtt tcagcctgta cgggtcacca gatacatatt gagggtcttt 2497021 cgggacattc aggtgcaagg agatgccttt ctcatccgcc ttatgcttca gaagcgtttc 2497081 aatctcacca agcattttgg ccggctcaaa cgtttcgata ctgagcgtga aattttgctg 2497141 ctcgattttt gagagatcga gcaaatcctg aaccaaagac tgaagccttt cgctttcctt 2497201 aagaataata gagagaaatt cagaaagcgc ctctttgtct tccatcgccc cgtccaataa 2497261 cgtctccgta aaccctttta tggacgtaat cggtgttttc agctcatgag aaacattggc 2497321 cacaaaatcc ttcctcatct gctctaattt cttcgtttcc gtcatgtcat ggaaaacgag 2497381 cacaattcct ttccattcat cgtccggccc cataatcgga acgccgtcca cttcaaaata 2497441 acgccgttct attttgatcg gcagtcttaa cagcttgcat ttctttgtct ccgtcataaa 2497501 aatgtcttcg acaagctgga tcacttcttc atgttcaaat gcatcgtgat aaagacggcg 2497561 cagcatatga ttcggattga tatgaaactg cttggcgtaa gacctgttta cgagattaat 2497621 aaagcctctt ccgtcgatca taatcagccc ggagccaatg ttttcaatga ctgtcagcag 2497681 ccgatcccgc tgcatttcct gcgttcgcgt catttccatc agatcaatgg caaggctgtt 2497741 catcgcatgt cctagcttat cagaacgcct aatatagccg ccgtacgtcc gtgcatcgta 2497801 gttgccctta gagagttctg tggctacatt tgtcgctgac tcaattgacc ttttataacg 2497861 tgaggtcatg ctggaataaa aataaacaat gacgataaat gcggtacaaa gactggccgt 2497921 cagcatcccc cacaattcgc cttttaagcc gtcgcttttt tcagaggcgg aaagcagcac 2497981 atatcctgtt ttttcacctt cgcttctaag tgaaagtccg taataaagct tgttatctgt 2498041 tgttgacaga ataccctcat ggccagaaac aagcgcctgc accttttggg aatcagccga 2498101 tctaccgttt gacccataca gcaccttacc gtctgtatcg ataacggatg cgctcacatc 2498161 aagcgcgccg cctgcatctt taatgatttt ctcatttgct tgattattca gattgccggc 2498221 atcaagaagc gaagccaagt attttgcttc tttttcaatg tgttcctctg ctttcctttg 2498281 atcagatgtt tcaaaaagct gctgtaaaaa cagcccgagg acacaaaaca ccagaatcat 2498341 acagacaacg aatacagaaa aaaggcgcac acggtattta ttcattcatt tttggctcct 2498401 ccagtttata ccccaatccc ctaatcgttt taatgtagat cggttttttg gtattgtttt 2498461 caattttgtc gcgaagatgg ctgatgtgca catcaacaat tctcgtatct ccggcaaaat 2498521 cataattcca gactgcgctc agcagcaggt ctcttgtcag aactctgcct ttatgtctgc 2498581 ctaaatagag cagcagttcg aattctttcg gtgtcagttc aagctgactt tctttaaagt 2498641 acgcttcata atgatcaggc aggattttca gatcgccgat tacgatctgg ccttccattt 2498701 catcgttctt catctcacta gagggcgcag ctatttccga acgccttaaa atcgctttga 2498761 ctctcgcatt tacttccctt ggactgaacg gcttggtcat ataatcatca gcaccgagct 2498821 ccagccctaa tactttgtcg aattcctcat ccttcgctgt cagcattaaa atgggaaaca 2498881 tcagtttttg ctgtctcagc tgcttgcata cttcgattcc gtccaatttt ggaagcatca 2498941 catcaagcac aatcaaatca ggtttctctg tttccgcttt tttgagtgct tcttccccat 2499001 ccgaggcggt aatgacatca tagcctgacc gttccaaatt gtactgtaaa agagtaacaa 2499061 tagattcttc atcatccaca actaaaattt tcttgttcat gctgtgcctc cagtattata 2499121 attccccgac atcctatttc tctattttat gtcatcttaa catgtttcat gattttattt 2499181 tagcgaaagc aggacattcc gacaattcgc cttttacatc atttttaaaa gaaataaaga 2499241 cgtttatgat agcgctttca tttatagtaa aaagagaaag gctgtattaa gcaagccttt 2499301 ctctcttttt attaggataa tactttcatg acatttttga cagattcaac tgatttattc 2499361 agctgcgctc tttcatagtc tgtcagttca agttcaatga tttgctcaag accgttgccg 2499421 cctacaattg taggaacacc aaggtagatg ccttcatagc cgtattcccc ttcaagataa 2499481 gcaattgtag gaaggacgcg gcgctgatct ttcaagatcg cttcgaccat ttctgtcaga 2499541 gaagccgcag gcgcataata cgcgcttccg tttccaagaa gattcacgat ttcgcctccg 2499601 ccttttctag tgcgctccac aattgcgtca atccgttctt tcggaataag agtttcaagc 2499661 gggataccgc cagcataaga ataacgcaca agcggaacca tatcgtcacc gtgtccgccg 2499721 agtacgaaac cagtcacatc tttcactgac aggtttaatt cctctgccac aaatgttctg 2499781 aatcttgccg tatcaagcac acctgactgg ccgattacac gctctttagg gaagcctgat 2499841 tctttgtaca ccgcgtatgt cattgcatca acaggatttg tcagcaccac aataatagag 2499901 tcaggagaat atttcacgat ttcctgcgta acgcttctca taatcttttc gtttgtagag 2499961 accagatcat ctctgctcat accaggtttt cttgcgatac cggctgtaat gacaacaatg 2500021 tcagagccgg ctgtatcctc gtaattggat gttcccgtaa tttttgcgtc aaagccttga 2500081 accgggcttg cttcaagcat atcaagcgct tttccctttg tcgggttctc caattgcgga 2500141 atgtcaacaa gaacaacgtc tgccagctct ttttgagcga ttaaaaatgc agttgtagct 2500201 ccggtaaaac ctgctccgat aacagaaact tttttacgag tatttcccat gtctctcttc 2500261 tcctttatgg ctagttttag gctttttcct tgcttagtcc atgtttttga tcagttcttc 2500321 tccgaactct gaacatttca cttcagtcgc cccgtccatt aatctggcaa aatcgtaagt 2500381 tacgacttta gaagcgattg ttttttccat agatttgata accaaatcag ccgcttcgtt 2500441 ccatcctaaa tgctcaagaa gcagaacgcc tgaaagaata actgaagatg ggtttacttt 2500501 atcaaggcct gcatatttag gagccgttcc gtgcgtcgcc tcgaaaatcg catgtcctgt 2500561 ttcgtagttg atgttcgctc caggagcaat gccgattccg ccgacttgcg cagcaagagc 2500621 atcagaaatg taatctccgt tcaagttcat tgtcgcaacg acatcaaact cgtttggacg 2500681 cgttaagatc tgctgaagga aaatgtcagc aatgctgtct ttgataatga tttttcctgc 2500741 tgcttccgct tcgctttgcg ctttgttggc agcgtctttt ccttgttctt cagcaatgcg 2500801 gtcatattga gcccatgtga agactttatc tccgtattct ttttcagcaa gttcatagcc 2500861 ccagtttttg aaggcgcctt ctgtgaactt catgatgttt cctttgtgaa caagtgttac 2500921 agatttgcgg ccatgctcga tcgcataatc aatggcagct ctgaccaagc ggcttgttcc 2500981 ttcttctgaa acaggcttaa tgccgatacc tgatgtctca gggaaacgga ttttattgac 2501041 gtttaactca ttttgaagga agctgataag cttttgcact tcttcagagc cttttgcata 2501101 ctcgatgcct gcgtaaatat cttctgtatt ttcacggaag atgaccatat cagtatcttc 2501161 agggcgtttt accggtgacg gcactccagt aaagtatctt acaggtctta agcagacgaa 2501221 taggtcaagc tcttgtctga gcgctacgtt caaagaacgg ataccgccgc cgacaggtgt 2501281 cgttaacggg cctttaatcg cgatgaaata ttcgcggatc acatctaatg tttcagcagg 2501341 gagccactca cctgttttat tataagcctt ttctccggcg taaacttctt tccatgtaat 2501401 tttcttttcg cctttgtatg ctttttctac tgctgcttcc aaaaccttcg aagccgcgtt 2501461 ccaaatatca ggaccggttc cgtctccttc gataaatggg ataatcgggt tgtttggtac 2501521 gtttaatact ccgttagaga ctgtaatttt ttcaccttgt gccacaataa aaacctccca 2501581 gtatgtaatt catatttaga aaacatttta tttttcttat atagaaaata aaatgatttt 2501641 tcctaacatt caatttaaag tgtaacccaa ttttgatgtc tgaacaagag gctaacctca 2501701 ttgacgcaag ccagcctcca atggttcttt aggctctttc ttcaatcgga acgaattttt 2501761 gtttgtcagg gcctgtgtaa tctgcccgcg ggcggatcag acggttgttg tcatactgct 2501821 caagaatatg agcgagccag ccggacattc tgcttacagc aaaaatcggt gtaaacaaat 2501881 catggtcaat accgaggctg tgatatacag aagccgaata gaaatcaacg ttaggcggaa 2501941 gctttttctc tgatgtgacg atgtcttcta tacgaatcga catctcatac catttgcttt 2502001 cgcctgtcag gttggtcagg cgcttgctca tttctttcag atgcttcgcg cgcggatcac 2502061 catgcttata cacacggtgg ccgaatccca tgattttttc tttcttttca agtttagcgc 2502121 ggatgtacgg ctcagcgttt tccacttcac cgatttctgt cagcattttc ataacgcctt 2502181 cattcgctcc gccgtgaaga ggccctttca gcgcgccgat tgctgcagta atgcctgaat 2502241 agatgtcaga aagtgttgcg acgcagaccc tcgctgtgaa cgttgacgcg ttcagctcat 2502301 ggtcagcatg taaaatcaat gctttgttga aggcttcaac ttcaattggt gaaggctctt 2502361 caccgtttaa tgtgtaaaga aaattctccg caataccgta atcttctctc ggttcaacag 2502421 gctcaagacc cttgcgaatt ctggaaaacg ctgcaaccag gccaggcacc tttgcctgaa 2502481 ggcggatcgc ctttctgtag ttggcttccg ggttcatggt atcagcctcg ctgtcaagca 2502541 ggcctagtaa tgaaattgct gtccgaagag cagccatggg atgaacattt tcgagggaat 2502601 aagatttgaa gtgctcaata atttcttgcg gaacggcagc ttcctttgca agctgctgct 2502661 ttaactcttc aagctctttt ttgtttggca gccttagatg ccaaagcaag tagatgattt 2502721 cttcaaaact tgcattctct gtcaaatcat cgatatcata ccccacatat gtaagggtat 2502781 catcaataat agaactaaca gatgatgttg ttgctacaac cccttcaaga ccgcgtgtcg 2502841 ctgtcatata taacatctcc ttttcaataa atttcccctt taagagtgtt gtaaaaacat 2502901 gaggcttact taaaaagcac gatgcaagta tttctctccc ccaaaaagaa aatgcttaca 2502961 ttttactggc tgctggaact aaaacccttt gcttttgaaa gaacataaca aatttttata 2503021 agcttattta agtttaagcc tattctcatt ataaacaata atcagacatt tgttaaatgt 2503081 ttacctataa tttttttttt ccattctgtg atttccccga aaaaacgcct ttatttgcgg 2503141 gtttttgcat aaaaaaaagc ggctttaagg ccgctttttt ttatgaagtg aacagtttta 2503201 cgatctgcat ggctaaataa gcaatccccg ctccgatcag cggccccacc gcaactcctc 2503261 caaaaagcgc gactgcaaga atggtcccga tcacgagagc agttgtaata tgcggatcat 2503321 tttcaagcag ggtcaggccg ttttttgcaa tcagcgccac tgcgatcccc gctccaaggg 2503381 cgatccatgc gtaggaagac cgcattgctt ctccaagctg cttaaatccg atttctcccg 2503441 tggcaatcgg gacaagaacg gcgatggtaa taatggtcac accccagtta atgccttttg 2503501 actggatggt cggaaataat ttctgatcaa gcccaacgat tttgatgatc aaaaggacgg 2503561 atacagcaaa gagcaatgat tggttttttg cgataagtgc gatagccaag agtaaaatta 2503621 aaaataaatt cgcttgtgta aacacatgcc atccctcctt taagatgaat gtattcatat 2503681 tcagccgcag cgtgaataca tataaaaaat aggacatgct gacgagagga ggaccgtttt 2503741 tgtgaatcaa tcttatatca ctattttttt cagaaccctc tttgtcatat caatgaccgc 2503801 agggtcgata gctgcggcct attattcgtt tccgttaact tatccgttcc tgatcgccct 2503861 tattctatct tcagtgattc atcctgttgt cgattatttg gacaaagtga caggattccc 2503921 ccgaacgata aatgttctgg gcgttcttgc tttttttctg ctcgcagcct tcggcgtgct 2503981 caccattctg gtagccgaaa tcgtaacggg aacagcctat ctagcaaaaa cgctgcctcc 2504041 gcatatcagc acgtttattt catattgcga aaaattgttt accactcata ttcagccgct 2504101 ctataacgag ttaactcttt tgtttcaaga attggaaacg aaccagcagg cttccatcgt 2504161 cactcatatc cagacactcg gtgattctgc cgctaaaaat gccgggctcc tgctgtccca 2504221 cattctagag atgatcccga gatttttcgc tcttcttccc aatacggcgg cggttctgat 2504281 tttttctctt ctggcaacct tttttatgac aaaggattgg cataagctga aagccatgct 2504341 tgttttaatt ctgccggatc gtgtgacagc taacagcaaa gcaatcagca gcgaattaaa 2504401 aaaagcaatg actggtttta tcaaagcaca agccgtcctc gttttcatca cgatggtgat 2504461 tgtatttatc ggcctttctc tcttaaaggt tgaacacgcc gcaacaattg cttttttaat 2504521 cgggcttgta gatcttctcc cttacttagg tgccggctcc gtatttgtgc cctggatttt 2504581 gtatttatcg attacgggcc agctgcccca agcaatcgga attggtatcc tgtacctcgt 2504641 cgttcttatt cagcggcagc tgacagagcc caagatacta agtaaatcta tcgggatcga 2504701 tccgctggca acactcatcg ccctgtttgc cggctttaaa ttattcgggt ttttaggact 2504761 gattgcggga ccggctgtac tcgtcatcat ccaagctttc atcacaacag gcgcattaaa 2504821 agaaatatgg tcctatatca ccgttcagca aaaataaaac ggcagccgtt ttttcatggc 2504881 tgccgttttt tatttgatga tgatccgctt attcttcgac attcctctca gccatttgaa 2504941 cagaatcggc ttacaccagc cgcgggtaaa cgggataaga agacaggcgc cggccaaatc 2505001 tgataaaaag cccggaagca tcagcaatag accgccaatg aaaatgcaca gaccgtcagc 2505061 aatcgcttct cccggcattt tgccatattg aagatcacgc tgaaccttat aatacacttc 2505121 ggttccttgt ttttttgcag ctgctgcgcc gataatgcca gtcagaatca tgaatagaac 2505181 tgtcggcaaa ataccaatca gatttcctaa aaataggaat ataccgattt ctattgccgg 2505241 aaacacaata aaaagcaaaa acaaaaatct catatccaag ccccccacac gtgtaacacg 2505301 ttctgttcaa caaaaggcat gataaagaga aaaggaaggg attccccttc cattttcacc 2505361 tgtaattaaa gaacgctcgc acggccttga tagactgcgc ctctggaagc gtcaactgta 2505421 atatcctggc catctgtcaa aatagatgtc gcattttcca gacccacgat aaccgggatg 2505481 ccaaggctta atccgactac cgcagcatgg ctagtcaaac cgccttcttc tgtaataaga 2505541 gcagacgctt tttcaaggga tgcaatcata tcacggtcag tgcttttggt aacaagtacc 2505601 gcaccgtcag tcattttttg ctcagcttct tttgcatttt gtgcaacgac aaccggaccg 2505661 taagctgatt tgcgtccaat gccttggcct ttagcgatga tatcgccgac agtatgaacc 2505721 ttcattaagt tcgtagtgcc ggactcaccg acagtgccag ctgtaataac gataagatcg 2505781 ccgtgtttta caattccgct gttcaatgat ttttggacag catcctcaag catctcatct 2505841 gttgagctcg cattttggcc gctttccgcg aatacgccag atacgagggc aagctttctg 2505901 gaaatagagt catttacagt aaccgcaaca atcggagcct gcggacggta ttttgcaatc 2505961 atacgtgctg tatggccgct ttctgtcggc gttacgatcg cagcagcatt caggttaatc 2506021 gccgtatgtg cgacagattg tccaattgcg tctgtaattg tcatgcccac ttggtctctg 2506081 cgttttgaga gaatttcttt ataatttaat gcttcttcag aacgggacgc gatgttatgc 2506141 attgtttgaa ctgcttcaac cgggtaactt ccggcagcag tttcaccaga aagcatgatc 2506201 gcatctgttc cgtcgaagat cgcgtttgca acgtcacttg cttccgcacg agtcggacgc 2506261 gggttgcgct gcatgctgtc aagcatttgt gtcgctgtaa taacaggttt gcccagcgcg 2506321 ttgcattttt tgatcagttc tttttgcaca agcggcactt cttcagctgg aatttccaca 2506381 cctaagtctc cgcgtgcaac cattaagccg tcagacactt cgagaatcgc atcgatgttg 2506441 tcaacgccct cttggttttc gattttaggg atgatttgaa tatcctgagc gttgtgctct 2506501 tcaagaagct cacggatttc gagcacatcc gtagaacgtc gaatgaaaga tggtgcgatg 2506561 aagtctactc cttgctcaat accgaaaacg atgtctcgcg catccttttc agtaatcccc 2506621 ggaagattga cacttacgcc cggtacgtta acaccttttt tatttttgag tgttccgttg 2506681 tttaatactt ttgttttgat ttcgcgttta gcggcatcta catcaagtac ctcaagaccg 2506741 ataaggccgt catctaacag aatcgttgaa ccttgttcaa cgtcatggac taaaccttca 2506801 tatgtcactg aaattttatc tgttgttcct acaacctcgt ccattgaaat aatgagctct 2506861 ttgcctgttt caagctcaat accgccgttt tccattgtat gtgtgcggat ttcaggacct 2506921 tttgtatcaa gcagaattcc aacgttcttg ccaagttttt tacttgcttc gcggatattt 2506981 ttaattcttg caccgtgctc ctcaaaatct ccgtgagaaa agtttaatcg agccacgttc 2507041 attcctgact ccattaattt cgtaagcatt tcaatacttt cacttgccgg accgatggta 2507101 caaacaattt tagtttttct catttggttc acttccttct gaaatcttca gccttcagct 2507161 gtacattaga tagacagttc ttttgaaagc tgatacatgt tttgctcaac tgtgtgtttt 2507221 gtctcaagta tttctataat atcatggtct acaagcttat tgttttgtat acctacacag 2507281 cgtccgcctt ttccttcaag cagcagttca actgcatatg cgccgagacg gcttgccaac 2507341 acacggtcag cagcactcgg agaacctccg cgctggatat ggcccaatac agatacccta 2507401 gtttcaagat ttgtttcttc ttcaatgcgt ttcccgaatt caacaccgct gcctacacct 2507461 tcggcaacaa taataatact gtgcttcttg ccgcgttcgt ggccgcgttt taagcgggca 2507521 atgatttcgt gcatgtcata gtctgcctca gggattaaga tcgattctgc gccccctgca 2507581 agaccggccc acaatgcgat atcgccggca tgacggccca ttacttcgat tacatatgta 2507641 cgttcatgag aagtcgctgt atcgcgaatc ttatcaattg cgtcaattac tgtatttaaa 2507701 gctgtatcga aaccgattgt aaaatcagtg cccggaatgt cattatcaat tgtacccggt 2507761 acacctacac atggaaaccc gtgttccgtt aattttttcg cacccatata ggaaccgtct 2507821 ccaccgataa caacaaggcc ttcaatacca agcttcttca agtttgctat ccctttttca 2507881 cggccttcaa ctgttttgaa ttcaggacat ctcgccgtat aaagcttagt ccctccacga 2507941 tgtataatat cgcctactga tccgagttca agcttttcaa tctttccgct gatcaatccc 2508001 gcgtatccgt tgtaaatacc gtaaacttca acgtcatgat agatcgcttt tctgactact 2508061 gcgcgaactg ctgcgttcat tcccggggaa tccccgccgc tcgttaatac ccctattcgt 2508121 ttcattctcc attcacctca gcaacatata tgattaaaca taacatgatc attgccctaa 2508181 aaacaatgaa aagggatctc catcctccct atgaaacctt acctattata caattaaata 2508241 aattgttttt aaataaaatt taaggaatgt cacaaaaaat aaacgtgagc caaaggcttc 2508301 acgtttattt agtttacccc gatatattga tcttcaaccg agactttgcc aattgcttta 2508361 tatttttcat aacgctgctg aactaattct tcttcgctca gcttcagtaa agtttttaac 2508421 gattgtttaa gggtttcgtc catatagctt gcctgcagct tcacatcatg gtgcgctccg 2508481 ccttttactt ctttaatcat atgatctata atacctaatt cttttaaatc cggcgcagtg 2508541 attttcattg tttctgctgc ttttttagca agactggagt ccttccataa aagtgccgcg 2508601 gcaccttccg gagaaataac agaataagta gagttttcca gcatatgcaa gtgattgcct 2508661 acacccagac caagggctcc gccgcttccg ccttcaccaa tgacgatgca gataacaggc 2508721 actcgaaggc cggccatctc aaacaggttt ttggcaatag cttcactttg tcctctttct 2508781 tcagctgctc gtccagggta tgcccccttc gtatcaataa aacagataat tggtctgtta 2508841 aatttgtcag cctgtttcat cagacgaagc gcttttctgt agccttctgg atgcggcatc 2508901 ccaaaattgc ggactaggtt ttccttcgtg tctttgccgc gctgatgccc gattaccgtt 2508961 acagggaggc cgtggaactt cgcaatcccg ccgacaatgg cttcatcgtc cccgtacgct 2509021 ctgtctccgt gacattcaaa aaagtcggta aacaggtgtt cgatataatc aagagttgtc 2509081 ggacggtccg ccagacgcgc gatttgaacc cggtcccacg gcttcaaatt tttgtaaata 2509141 tcatcctgaa gcttagcgag acggtcttcg agccgttcga tttccgcact tagatccata 2509201 tcggaatctt gggtgaattt ttttagttcg gcgattttgg tttgcagttc aatcaccggt 2509261 ttttcaaatt ctaatcttgg agccactcaa tgtcacctcc tgtttgatgc atatccagca 2509321 gattttctaa cgtttttttc atatcgtcgc gatgaataac cgcatcaagc tgtccatgtt 2509381 ttaataaaaa ctcagccgtt tggaagtcct caggcagttt ttctcctatt gtctgttcaa 2509441 taatccgtct tccggcaaaa ccgatcagcg cgccaggctc agcgaaattg taatcgccaa 2509501 gggatgcaaa gcttgctgat acgcccccgg tagtcggatg cgtcattact gaaataataa 2509561 gaccctgttc ttcactgaac agttttaacg cagagcttgt ctttgccatc tgcatcaaac 2509621 ttaatacgcc ttcctgcatt ctagcaccgc ctgaagccgt aaaaataata aacggaactt 2509681 tatcagcttt tgctttttca atcgcaagcg tgattttttc accgacgact gaacccatgc 2509741 tgcccattct gaatgaagag tccatgacgg cgacaacagc cgggtgtccg ccgatggtgc 2509801 ccttgcctgt cacaacagcc tcgtttaagg atgttttctc gcgatctttt tcaagctttt 2509861 ccagatatcc cgggaaacca agcggatttt ccgagagcat tccctgatta aattcctcaa 2509921 aggattgttc atccatcaag ctttcgatac gctgttttgc gttcattggg aaatgataat 2509981 cgcagttcat gcatacccgc atatttttat ccaactcttt agtgagcatg atttttttac 2510041 acttaggaca ttttgtcata atgccttccg gaacatcgtg cttcgcttga tcagacggta 2510101 cggaagcata ctttttcttt ttcgtgaata tatcctttaa caaatgatta cctccctttt 2510161 gtgaagggtt ctcttcaccg catgtcatca aacagataga cttgctaata actttaccga 2510221 aactattgta ctttttttgt caaacgctgt catcctcaat tcgacaactt tttattcgat 2510281 gacgtgctcg gaaaggcttg tatgaaatca gataaggtgt tgaaacgaca aggttgacag 2510341 cgcattcaaa aataatgtta aacccggctg aaattttttt aaggctaacc ccctaaaaaa 2510401 atttcagccg tcagtttaac ttgagaacag cgcgccggtc tccgccaacg cgctgccatt 2510461 tttggaatga attaaaatta ttcaccaata atcgtaagtt ttcttgtttt ttctgcgact 2510521 tcctcagggt caacagtgat tcttgcaaca cctgtttcca tcgcagcttt tgccacagcc 2510581 ttcgcaacag caggcgcaac acgtttatca aacggtgcag ggatgacata gtctgcgcta 2510641 agctcatctt ctgaaaccag tgaagcaatg gcttcaaccg ctgcgatttt catttcctcg 2510701 ttaatatgag tggcacgcac atcaagcgct ccgcggaaaa taccagggaa tgcaagaaca 2510761 ttgtttactt ggttcgggaa gtcagaacgg ccagttccga caacgcttgc tccggcttca 2510821 cgcgcatctt ccggcatgat ttccggattt ggatttgcca ttgcaaagat aatcggatct 2510881 tttgccatgc tttgaaccat ttcttttgtt aacgcgcctg ctacagagac accgataaat 2510941 acgtcagcat caacgataac atctttcaga gaaccgtctt tgcgatcttg gttcgtgaac 2511001 ttcgccactt catttttgac atcgttcatg ccgttcgggc gcccttcata aatggcccct 2511061 ttggaatcgc acatcacaat gtcgcgaacg ccataatgat gaagaagctt gataatcgca 2511121 atgccagccg cacccgcgcc gtttgcgaca actttaatgg atgacatgga ttttccagac 2511181 agtttcagcg cgttcacaag acctgctacg gttacaatgg cagtaccgtg ctgatcatca 2511241 tggaaaaccg ggatgtttgt ttcttttttg aggcgctctt caatgataaa gcagtttggc 2511301 gctgcaatat cttcaaggtt gacgccgcca aatgtcggtt ccagcaattt tacagtttca 2511361 acgattttat caacatcgtt tgtgtttaaa gcaatcggga acgcatctac gcccgcaaag 2511421 cttttgaaaa gaactgcttt cccttccata acaggaagcg ccgcttcagg gccgatgttt 2511481 ccaaggccaa gcacagctgt accgtcagtt acaactgcta ccatgttccc cttcattgta 2511541 taatcatata ctttgttaat gtcttcatga atatccttac acggttctgc aacacccgga 2511601 gaatacgcga ggcttaaatc tttcgcattt ctgacctcta cttttgattt agactccagt 2511661 ttcccctggt tgactttatg caggtgtaat gcttcttctc ttaatgacat tctcctaaac 2511721 actccttatg gatatttttt gattcgtata ctgctgcgtt gattgctgca ttctgcggag 2511781 taaatctatc tgaatattta aacaggatca cataattgct ccaattgtat aacaaaaagc 2511841 gaatcgttac cactgtttta aaacgacgtt tttttgaccc aacagctctt ttaagcgata 2511901 taacacctgg tgatctgcat tgatatggaa cgactcaggt agcttaatcg tctgtttttg 2511961 cctttcataa tagagataaa cgcctgtttc ccctttatgc tccagcaaaa tgcgcttaat 2512021 ctttgccagg atctcctggc tgtgctgact gctttctatt tttatataaa ccgatggcgc 2512081 tttttctgca tccatatctt ctaataattc tgcccgggac atgatgaatt ggatcttatc 2512141 ttgtctaact tcacatttcc ccgcagtgaa caaaagagcg ccttctctta aaacgggaga 2512201 aagctgtctg aattgttcag ggaagactac ggcttccatc tcgccggttt catcactgag 2512261 cgttaaaaac gccatgtttt gacctgtttt cgtccgaatc gttttgatct tcgacagcag 2512321 aacgcctagt gaaagctgcc ttttgactgc ccgctgagcc tgcagaatgg agactgctcc 2512381 ttgcgcagtg agctgttttc ggaaggcgga gaggggatga tttgaaaaat aaatgccaag 2512441 cgtttccttt tcaaacgcaa gtaaatccac cagaggaagc tcctccgtct ccacatactt 2512501 cggcttaatt gaaaacgatt catctaaaaa caatcccatt tggtcatcgt ccgcggcgaa 2512561 tagctcagca tgttccaaag caacatcaat ggatgcgagc agcgtggccc ggttttggcc 2512621 gaattcgtcc atcgcaccag aaaagataag tgcttcaagc attttgcgat ttacgctttt 2512681 tgacggcacg cgaaagcaga aatcgaaaag atcttcaaat ggtttctctt ttcttgcttt 2512741 atatatatct ttgactgctg agacgcctac actttttatc gcgcggaggc tgtatctgac 2512801 agatccgttt tcaactgtaa acggaaaact gcttttattc actgacggag gaaggatacg 2512861 aatcccgctc ccctttgctt cgtaaagata ttgagagatt ttatcctcat tgccaatgac 2512921 gcttgtcagc aatccgcaca taaaatataa cggataatga gctttcaaat acgcaagctg 2512981 gcacccgatc atgctgtatg ccaccgcatg gcttctgtta aagccatagt ttgcgaattt 2513041 gacgattaaa tcgtagacct catttgcagt gtctacagaa tactcctttt ttaagcaccc 2513101 ttcaacaaaa tggcttcgct ctctgtccag gatttctttt ttctttttgc tgaccgccct 2513161 tctcaatagg tccgcttcgc ctaaagaaaa ccccgccata cgggaagcaa tcatcataat 2513221 ttgttcctga tacacaatga cgccatatgt atcttccaaa atgctcctta aatcttcatg 2513281 aggatagtga acaggcgccc gaccgtgttt acggtcgata aataacggaa tattttccat 2513341 cggacccggc cggtacagtg cattgaccgc cacaatatct tctaggcccg aaggtttcag 2513401 ccgtttcaag acgcttctca tccctgcaga ttcaagctgg aaaatgcctg tcgtatcccc 2513461 ttttgacagc aaggagaacg ttttgtcatc gctgtaggaa atacttgaaa ggtctatttt 2513521 aatattttct tctttttcaa tcattgaagt gatggattca ataagtgtca gattcctcaa 2513581 acctaagaaa tccattttta aaaggcccaa gtcttcaaga tggtccatcg cgtattgcgt 2513641 taaatagatc ccttcatgcc cttcttgaag cggaacaaca tctgttaacg gttcttcact 2513701 caggacaacg cccgctgcgt gggttgatgc atgccttggc agcccttcta ttttccgggc 2513761 aattgaatag acttgctgaa gcaggcttga ctcccgaagc cgcttatcca gctgcggtga 2513821 ctgctgtctc gcttcatcca gcgtcattcc cggtcttgaa ggaatgagtt ttgcaagctg 2513881 atctgcctcc ttcgggctga cgccgaatac tctgccgacg tcccggagcg ccgcctttgc 2513941 cgcaagtgtt ccaaaggtga taatctgtgc gacgtgcatt gcaccgtatt tctgctgaac 2514001 atattgaatg acttcatccc ttctagtatc gggaaagtca atatcaatat ccggcatgct 2514061 gacgcgttcg ggatttaaaa atctttcaaa cagaaggtga tgcttaatcg ggtcaacatc 2514121 tgtgatatac agcacatatg ccacaagaga acccgccgca gaaccccttc ccggtcctgt 2514181 aacaatccct ttttcatggg cgtgcttcat aaaatcccac acgatcagaa agtaatcgct 2514241 gaacttcatc cgcttgatga catcaagctc atattgaaga cggcgaaggt atcgttcatc 2514301 aggcttgccg aaacggctgc ggagtccctc catacagata tccgttaaat aatcatcagc 2514361 ggacgttccg tctggggtcg gaaaagacgg tagacgggtc tgcccgagac tgacgtcaac 2514421 ccggcattgt tccgcgatct ctacagaagc ttgcagtgcc tcgggatgct ctcgataaat 2514481 gttttgcatt tcttcgagtg gtttcaaatc gagatcaggc aaatcttcag cgggtgcatc 2514541 cgtcagtttt tcccccgctt taatcgcttt caaacaacgg taggcagcct tatcttcctt 2514601 ccttatgtaa tgcacatcgc ctgtggccgt aacagggata cccgtttctt ctgacagctt 2514661 tagaatctgc tcagacaaga cttgattccc tttaaaaggc tgataggaga aataaaaagc 2514721 tccctttccg aatatagact gaaattccag cgaggcttga gcagcctgtt cgaacagccc 2514781 tccttcaaga agcgtttcaa tatatccttt ttcgccgggc gttattgcga taatcccttc 2514841 tcgataactg tgaagccatt tcggcttcag tccgcctttt gatttagatt gcagaacgct 2514901 gctgattttc agcaggtttt gatagcctgt attcgatttt gccagcagga cgagcgggta 2514961 tgcttcaagc tcgctgtcat ctgtaaaaac agaagccgtc aaaccgatta ttgggttgat 2515021 ccctctcgcc ttgcaagctt tataaaattg aatagctccg tacatgacat gatcatctgt 2515081 cagcgccaaa gacgcatatc cgagcctgtc agcttcactg acgagttctt ccacagccgc 2515141 ggcgctgttt agcaggctat acccgctatg cacttgcagg tgaacaaaag acatgctatc 2515201 acctctttct cattacgatc catttcttcc ttcattataa ggccggtttc caaaagaaac 2515261 aaatgttctt ttttgactca tcatcatact tgtcctgaaa gctcaatatg atataaaagg 2515321 tgaggtgata aagatggatc aggaagcagg atttatggtg aattttatca atagctactt 2515381 cattgcgtta ggggtgctga tcgggggcgc actcatcgga gggctcggag catacttggc 2515441 aggcgaaccc ccgcttacag ccattacaaa gcttgccaac cggttaaaaa tatgggcgct 2515501 tgtcgcagct atcggaggca cctttgatgc ggtatacagc tttgaacgcg gcatactcga 2515561 aggcaatacg agagatatct ttaaacagct tcttttaatt atttcggcca tggggggcgc 2515621 gcaaagcggc tggcttatta tatcatggct gacccaggag catctttctt catgagggtc 2515681 ccccagcatt acaaaaaacc gggatggcag cgttttttcg cgggaatgat gtgcggagcc 2515741 gtaatcagct ggttcttttt cctgtttact tacggaacat tccaagagga gcaggtcagc 2515801 ctcatcgaaa agcaaaaaga gcatgtaaaa gacttgaaca atcaaatttc gatctatcag 2515861 gaagacctcc ataaactgaa tgaagataat aaaagaaaac tgctgattca aagcgtcagc 2515921 gtcaaattgc tgaatgggga taaatataaa atatcacagc cggataaaac gaaattcgag 2515981 gagcatgtaa aggatgatat ttcagaggtg attacaaaag acatagagag cgtctatcaa 2516041 acaaaggatc tcttgaagcg gacaattgaa aataaagtct atatgatcaa tgaaaaaaaa 2516101 tacgaggcaa ccgtcagaga attgattatt tatacgaggc tgacagtgga acttgaaatt 2516161 tctttcgcca cataattatg gatttttttt aaattctcca aacttctgtc gctttttccc 2516221 attctttttt ataaactata tgtgaggctt aatggcgaaa ggaaggagga agggaaatgg 2516281 aggtttacag tgaccgtcag ttagcaaaag atcaagcagc ccgtctcaga caaggttttt 2516341 ctgcatatgc cgaaacaaac tcactcgctt ccctcatcaa aaaagaactt caatcacaca 2516401 atctccaagt ctacgaggac cttactgatt tcggctgctg gttcatcccc gtcacagatg 2516461 aacactaaga gagagggtct cccctctact cgtgttcttt acataatgtt tccagatcag 2516521 ctaaaatacg atcagcttca tcccagctgt aaatagaggc gcctgaagct aacggatgcc 2516581 ctccgccgtt atatttccgg gcaagtccgt taatgacagg ccccttcgaa cggaatctga 2516641 ctctgatttg atcgtcttct tctacgaaaa acacccaggc gcgaatacct gagatattgc 2516701 caagcgtccc gacaagctgc gacgcttcag aagccgttgt gccgaatttt tcaagcgtat 2516761 cctttttgat gaaaacagaa gccgccccgt tttcggacaa agacacattt tgaaagataa 2516821 agccgttaag cttcaccaca ttcagttttg tttcatacaa ttgattaaat aactctgagg 2516881 aagagaatgg atactgaatg agctcgcctg catattttag tgttttttcc gtggtattcg 2516941 gaaataaaaa gcgtccggta tctccaacaa tgccggcgta gatcagctct gccgctttcg 2517001 tattcagctt ccagccgtgc tcttttcctt ctaaatacag ctcgtaaatc atttcactta 2517061 ctgagctggc gcttgtatcg acccagagaa ggtcaccgta tggatcttcg ttcggatggt 2517121 ggtcgatttt cattagtttg gcgcctgaag gataacgctg atcgtcgatt ctttcctgat 2517181 ttgccgtatc gcagacaatg acaagtgcgc cttcatatgt ttcattgtcc acctcatcaa 2517241 gggaatataa gaaagagagg gacggttcag gcgtgccgac cgcaaaaata tttttttcag 2517301 gatatgtttc acgcaggatt tccgtaagcc cacactgtga tccgtaggca tccggatcag 2517361 gacgcacatg tctatgtaag ataatcgtgt catataatga tatggttctg atcaattctg 2517421 ttttcatttg atactccttt attgttttta ttcattaaat cacattctct gccgacggaa 2517481 aagaaaaata acgtcaaaac caagcccgtt tttgtataaa atggggttgt aaacttttac 2517541 gatggaggat ttcatttatg ctggttcttg tttttttgat tgggctttca gcctgctttt 2517601 atgtgtacta taaagtaaaa ggcgtacggg caaagccatc tttggcaaaa gaaatatgtt 2517661 cagcaaaatc aagcatggcc ttagggtcac tagtcctgtt ctacgggctt aaccaaatga 2517721 tattattcca ttcagtatta acgttagtaa tcggcggtat ctttatcgtc ataggagcag 2517781 gaagcgcttg ggcaggttat aaagccttca ggcattacaa tccccttcac gccaaagaag 2517841 ctgaaagaga tcacgcgtaa ggggcgcctg aacgtccctt agcttctttc catcagctga 2517901 accatcagca tcgctttaga cacgatatga ccttggctgt gcacttccac ttccattttc 2517961 ccaaactttc tgccggcctc caagatgcga ggtttgactt cgatgactga ttccatctgc 2518021 acaggcttca aaaagaagat ggtgatgctc tctatgacga gttcgccgcg ttttttcgag 2518081 cgcaaaaatc ggtttgccgc ttgcgtcaaa atggtcgtaa atacgccata agaaatggtt 2518141 ccaagctgat ttgtcatttg cggcgtgact tcatactcgt aaaccgtttg atcttcttta 2518201 tcatcaccct catctttaaa cccccttgaa acgatatcat caagcttctc cccgacctgc 2518261 ggctgctttt gaatcatttg aagagctttc aatacgtctt ggcggctgat catgccgatg 2518321 agtttttggt ggccgtcagt gacgggaagc acttcgatcc cttcccatac catcatttgc 2518381 gcagctgaag cgacagatgt tttcccaata accgtgacgg gatttttggt catgactttt 2518441 tctatagatg catttcggtc atggccagca atatcttttg atgtcagaat gccatggatt 2518501 ttcatttgat cgtcgacaac cgggaagcgg ccgtgccccg tttcaaaatt tttctcatac 2518561 catttttcaa gtttatcctt aggcgaaaga tataccgtgc ggtcagcagg tgttaggatg 2518621 tcctccacca aaacaatttc ttttttgatc agctggtcat atattgcccg gttaatcatc 2518681 gcggcaactg taaaggtgtc atagctcgtg gataaaatcg gcagttcaag ctcatctgcc 2518741 agctgcacaa tgctgtcatc cgtgttaaag cccccggtca ccaatacggc cgcgcccgct 2518801 tcaagcgcct gcctgtgtgc attgattctg tttccgacaa tcaaaagatt ccccgctgcg 2518861 gtgtaacgca tcatcgcgtc aagctccatc gcgccgatga cgaatttatt caatgtctta 2518921 tggagccctg ccctgcctcc gagcacttgt ccgtctataa catttacaac ctctgcatag 2518981 gtaagctttt caatgttctc ttttttcttt tgttcaattc tgattgtgcc cacacgttca 2519041 atcgtgctga caaacccttt attctctgct tccttgatcg ctctgtacgc ggttccttcg 2519101 cttactttca tttcctttgc aattcttcgg acagaaattt tttcaccgac aggcagtgaa 2519161 tcgatatacg ttaaaatttg ttcatgcttc gttgccaagc ctttcacctc taaggacagt 2519221 cttcttgttt ttattataag gtttcaaagg atttatacgc aatgaggctg gaaaataaaa 2519281 aagaagcccg accggcttct tacagcgttg atttcgttcc agtcaaacgc aaggaccacg 2519341 tgattccttt tacatcgtaa agcggaaaaa cctttatttt tcttttaaat ggacatcaac 2519401 cgctgtctta acaatatttc gattccctat tttagataaa acaaataaaa ctgcggatag 2519461 ccatatcgcc cctatggccg tatagatcaa tggatgaaca gctgtgtttg cgatccattc 2519521 atttattaat gttctggcat ttaccagaat aataaatcct cctacaagca cacccatcaa 2519581 ttgcggatga aacttctgca ccagccatgc tgcgataggg gcagcgataa ttccgccggc 2519641 cattagtgaa aacacccata accaattgac gtcctcccat cctaatgaaa taagaaaacc 2519701 ggcggttgca gatacggcga tggcaaattc acttgtgtct acagtcccga caactttcct 2519761 cgggctcaag cctttgcggg ataataaaat cggagtggtc accggtcccc agccgcctcc 2519821 gcctgtggca tctgcaaaac cagcgatcac tcccaatggg atggattgtt ttcggtttaa 2519881 cggcacatgc ttcttctcaa gagccggctt atattgaaat aaaaacctga tcaatacata 2519941 tccgcccaga aggagcaaaa acaaagaaat atagggtttc gccacatctc caggtaattg 2520001 gctgaggaat gccgcgccta aaaaagcgcc tatagagccg ggaatgacaa gctgataaac 2520061 ggtttgtttg tcaacattgc caaatttaat atgcgacact cccgatgcgg cagtcgttac 2520121 gacttccgct aaatggacag aagccgaagc cacagcaggt gtgatgccaa acgccaataa 2520181 caaagaagtt gaggtaaccc cataagccat acctaacgaa ccgtctatta actgcgacaa 2520241 taaaccaata aatgcaaaaa cgattaattt cttcatcaga acaccccatc tatatcaatc 2520301 agatattttt gactcttcat tcgaatctaa caatctcttg gcgctttcat ataaaaaata 2520361 agaggctttg ataattgcag tttcatctat tgtaaatgca gggtggtgcc aatcatgatc 2520421 accgtctgtt ccaaaaaacg caaaggatcc cggaatatgc tcaagataat aagcaaaatc 2520481 ttcccccgcg gttgatgggg cgggatcaat gacttgaagt ttcgctttat gtgcagcgtc 2520541 tcgcaccagc cccgtaattg cctcatcatt acaaagcggc ggcggtccgg aatgccactt 2520601 cacatttgcc tttaacgaga aagcggcaga aatctgctct gtgactgcaa aaaaacgctg 2520661 tttcacttga ttacgaacct ctgaatcaaa tgtacgaaca gtgccctcaa tgaccactgt 2520721 atccggaatg acattccaag tgctgccgcc gttgattttc cctacggtta aaatcgcgct 2520781 ttgcagcggg tttacatttc tgcttacaat cgtttgcagg gcgacaataa gctgagaggc 2520841 gccgataatt ggatcaaaac cattatgcgg caatgctgca tgagcacctt tcccttctat 2520901 ctctacttta aatcggtcaa cagcagccat aagcgggcct gtttttaacc ctacagtccc 2520961 aaccgcgata tccggtttat tgtgaaggcc aataaccgca tcaatgccat ccagttggcc 2521021 gtcctctatc acttttgtag cgcctgcacc cgcttcctct gctggctgaa ataataaacg 2521081 aatctttcct ttcagactgt cttgattttc cttcaataaa aaggccgcac caagaagcgc 2521141 tgccgtatga aaatcatgac cgcacgcatg catgatccct ttatgtttag acgcataagg 2521201 caatcctgtt ttttcttcaa ttggcaaggc gtcaatatca gccctcaaag caatcgccgg 2521261 accttctgac tcccctgcta tgtctgcgaa cacacccgtt tttagagcag tagggcgaat 2521321 ctgtatcccc ttttctttaa ggcatttttt tataaaagca gttgtttcaa attcttcttt 2521381 tgacagttca ggatattggt gcaggtgccg gcgaatgccg atgagctgct tttctagcgt 2521441 tgagagattt acgggattag actcctcttt caacgtcagg atgtcatttc ctgtagtctg 2521501 atatggatag gagccttcta tatttctcca ataatccaaa gacatatgtt ccgctccttt 2521561 ccctatccca atatattttc ttcagactct tcaacataag atgaaataaa tcggttcaat 2521621 ttatcagcaa gaccgcccgc cccaaatctt atatacttgc tggaaacttt cggattatct 2521681 tctttcaaaa agcttaaaaa agataaaata taaatgcgcc tgtaagctac ttgtgtaatt 2521741 ccgtactcaa aaaaccagtt atcaatgaca ttgtatacgc ctcggttgac gccatatagg 2521801 ttattacatt tcttgtaaaa gcagagatcc ggaagattta actcctgatg ggaaagaagg 2521861 ctttcttttt tgtttggtgc cataatccca atcagctcaa agcgttttgc aacgcacgaa 2521921 atatcctttt taatttgctt tgttaaagac tccaaagaat caaaccttct ttcttctcta 2521981 attttaaaga gaatgctgca ttcgattttt tctccataaa tgtctctatg aaagtcaaac 2522041 aaaaaaatct ccaatgtctt ttcaaggtta gagcccaccg tcggtttcac accgatattc 2522101 ataaccccta aatgaaattg atgattgact gtcgccagaa ccccataaac tccattacgc 2522161 agcccatgta tttttgcatc tacatttgcc gtggggaatc caagctttct gcctaattgt 2522221 tttcctttca caaccgtacc ggcaatgatc gtcaaaaaag tcagcctcct ctctcagctt 2522281 ccgcattcga tcagacgaaa cctaatgatg tgatgaatgt aaaacggatt gatgctgcgg 2522341 aatgccaaga ccgagatttt cccgcaatgt cccgccgcga taatcttgac gataaagccc 2522401 tctttcttga agaatcggaa tcaccttttc tacaaaagca tcaagtgttc ccggtatatc 2522461 cgacccaacg ataaacccat ccgccgcctc agcgttgaac caagtttcaa ttaaggatgc 2522521 gacacgctct ggtgttccga tgaatagagt ccgtggaaaa gccatttcct gtgctacctc 2522581 ccgcaatgtc agatttctgg cttttgcttc tctcttaatc cggtctgttg tgctttgaaa 2522641 cgcattcttt cccacatcgc caatatcggg aaatggctca tccaacgggt aaacactcag 2522701 atcataatca tcaaaaaaac gggccaaata agtaacagca ttttcaatcg gtatcaattc 2522761 tgcaaattca cgatacttct tttccgcctc ttcttccgta tctgccacaa tcgggctgat 2522821 ccctggaaaa atccgcacac ttgaaggatc acgcccttca tcagcagctc ggcttttcac 2522881 atccgcataa aacgcttttg tctcttctaa tgaattggaa tgggtaaaaa tcgcatccgc 2522941 atttttagca gcaaactgcc ggcctgtttc tgatgaaccc gcttgaaaca ctacaggctc 2523001 tccctgctta gagcgcccga tattcaaggg cccctctact tgaaaatact ttcctttatg 2523061 attcaggcga tgaagcttcg cctgatcgaa aaactgccct gttttcttat tgtgtataaa 2523121 tgcgtcatgc tcccaggaat tccacagccc gcgcacaaca tccaaatgct cttgtgcgat 2523181 ctcgtaacgt tcagtgtgtt ctggcaaatt agacttacta tggttgcgcg ccgctccttc 2523241 ctgcggcgaa gtaaccagat tccagccggc cctgcccccg ctgatatggt ccagcgacat 2523301 caattgtctg gagatagtga atggctcagt aaaagatgta gagaacgtcc ctactaaacc 2523361 aatatttttg gtaaccgatg ccagcgcaga taaaatggtg atcggttcaa aacggtttaa 2523421 aaaatgagga atcgattttt cagaaataaa taagccgtct gcaatgaaaa taaaactaaa 2523481 caaacctttt tcagctgttt gcgccttttt catgtaaaat tcaatattcg tgctggccga 2523541 gggatcaaca tcgggatgac gccagccgtc agttgttccc ccgacaccgt gaatcatggc 2523601 tccaaactga ataaaatctg cacgtgtcat ctttttgcct cctttatctg tgcatgatta 2523661 gcaagtgcaa gatcaaggtg ttcaatgccg atttcagtta tcccttgata ctgattgccg 2523721 cgcccgattt cgaccacagg cacatggcgc accccatatt tcacctgtaa aatatcccga 2523781 agcttttctt tctctgaaac atcgatattt tggaacggga accctttttc attcaaataa 2523841 ttcttgactt cctcacaata cgaacagcct tttttactcc aaaccacaat gttcacaaca 2523901 tcactcattc ttctgtccct ccttaacgtt ttgcagctaa aactgcatcg ctcagcagct 2523961 gataagacag ctgtttttct acagcatttt tgatcggtgt aaaaataaca aaatcattga 2524021 ttttgtatgt gcctgataaa cgtgttaatt cttctgccac ttcttccttt gttccggcaa 2524081 taatcccggt tttttgcacg atgatgtcat agggctctgt gacgttttcc agataggcct 2524141 cagcctgttc gcgggaaccg acgttgacct tacgcccgtc tttcaaaacc acttttatcg 2524201 attcacgcga cacaatatgt ttttccgctt cttcttttgt atgtgccgca aaaacagcgg 2524261 gggcaagatg aaattcagcc tcagatcctg gcgggagatg cgcgtcaaat gctcggcggg 2524321 cttccttcag cacttcctct tcaccgttaa taaagtaagc aaagacaaaa gagattccca 2524381 gttttgcagc agaaatggca ctctctgtgc ttcctcccaa tagaaaaata cccggcttcc 2524441 gatcaacctg cggcctagga cgcaatgcgg catagcggtg ggtatcagga aaatcatccc 2524501 gaacgaaatg agtaagctcc tccagttttt catcaaactg acgcaccggt tttttatatt 2524561 cggcctgcag cgcgtctgtg gacagctgaa acccgccggg cgctttgccc actccaagat 2524621 ctatacggcc gggagctaac gctgatagaa gatggaattg ctccgctact ttataagagc 2524681 tgtaatgctg cagcatcact ccgcctgatg ctaaacgaat ttttcttgtg cttgcagcaa 2524741 gatagcctaa aagaacctcg ggtgcagacc ctgcaatctc atcattgttg tgatgttcgg 2524801 ccacccaaaa tcggtgatat ccacattctt cagccatttg tgccaatttc actgtatgct 2524861 gtaatgtatc agctgctgtc tccccttcac caatcaagct ttggtctaaa atacttaagc 2524921 ggatcatatc accggctcct ttatgtgttc ttttggttca aataaatatt ccggcgaaac 2524981 acggcggaga aactgcctcg ttctgtcttt tttggtatgg cggaagactt cctccggggt 2525041 tccttgttca acaatgactc cttcatccat aaaaacaact tgatcagaga cccttcttgc 2525101 aaactccatt tcatgtgtaa caacaatcat ggtggctccg gttttcacga tttccagcat 2525161 tacctcaagc acttcaccga ccagctccgg gtcaagcgct gccgtcggct catcgaacag 2525221 cagcacatca ggatgaatgg caagcgccct tgctatccct accctctgct tttgtcctcc 2525281 cgataactga ctcggataag cgttcaattt atcttgaagc ccgacctttc tcagttcatt 2525341 ttccgctacg gcatacgcgt cttgttttct cattttccgg gcaatcgtca agccctccat 2525401 gacattttca atcaccgttt tgtgagcaaa caggtggtat tgctgaaata ccattgccgt 2525461 ctgttttctg agccagtgaa cctctttttt ggacggaaag cggcaattaa tcactttgtc 2525521 atgtatagaa atgatccctt cgtctggacg ttctaataaa ttcaggcacc gtaaaaaggt 2525581 ggttttccct gatccgctcg gcccgataat cgtcacaact tctcccttgc gtaccgtgag 2525641 atttatccct tttaatacat ggtggatgcc aaactgttta tggatatttt taatctcaat 2525701 cataaagtgc ctccttgaaa tctggctgcc tttctctcta atactccatt tgcggattct 2525761 aggattagag tcagcaccca atagataatc gctgctccga taaacgcttc taaaaatgca 2525821 taattatcag aagcaacgat agtcgccgtc cctgtaatct ctgggacagc cactatagcc 2525881 gcgatagagg tggtatgcaa aaagccgata cccaaatttg tgaagtttgg gatggaaacc 2525941 ttcagcgcct gcggcaatat tacacgccga aaggtttggc tgtatgtcaa gccgattgaa 2526001 taagccgctt cgacctgtcc ggtatccatc gccagaatgc ccgaccggat gatttctgtg 2526061 agataagctc cggcagttaa agacaaggcc atgatgacaa acatggagac cggtatctca 2526121 ttagcggacc agccgagatg aaaaaaactg ctgacttgat ctgcaacagg cggtatccct 2526181 aaataaatca acataatgtg aagaattgca ggtgtacttc gaaagaaaga cacataaaac 2526241 cttgagcaag ccaccaagcc cttaattcta aaaattctaa caattatatt tccaagagcc 2526301 acgagaaatc caaacacaat cggcaaaaca gccatcatca atgtcagagg aatggtcttt 2526361 accatttctt tcatggcgga aacgataaat ggaaagtcaa attgcaatct tctcccccct 2526421 catccgaaga aatatatcaa tgtatgttca tgtcaaaaac agtaacaatc cttgtttgat 2526481 tcttcttgat tcgtttttct gccactcgaa agaaccattc gaataaaacc gctacagcat 2526541 aataaacaat cgatagcgca atgtaaactt caagagaatg gttgcttgag gtaatcagtg 2526601 tttggcccct tccggacata tccataacac ctattgaaaa ggctagagac gtatctttta 2526661 aagaactgat caccatgttt cccatattcg gaaacgcctg gacaagtgcc tggggcagaa 2526721 cgattcgcct gaaggcctga ctaccgctta agccaatact gtacgccgct tccgtttggc 2526781 ctttatctac actgcccacc cccgctcgaa tgatttctgc ggctgccgct gcattgctta 2526841 acgcgtaggt tgcgacagca gcataaaacg ggtccatttt tgatgtatca atcccgataa 2526901 gccccgtaag cgccgggatc ccgtaaaaca cgatgaaaag ctgcaccatg ataggcgttc 2526961 ccctgaaaaa cgagatatac acttttgcca attgatttac aattggaata ttatagatgc 2527021 ggggcagtgc cagaaagagt cctaatacaa aaccgaaaag caaggacagt gttaaaatgt 2527081 ataatgtaac cggtaaataa gcggttaacg tcggcacaaa atctccaatc atgttcatat 2527141 caaacgcttt ttccatcact gctccctctc tttttaccta atactgctct ttggaatagt 2527201 cgtcaccaag ccatttcaaa ctgagccttt tcaacgttcc gtcatcaatg atttcctgta 2527261 aggctttatc aatatcgtca cttaacgttt gttcattttt gttaaacata aaatacactt 2527321 tggcatttga aagcacatta ccgacggttt tttctttaat agtgctcgtc ttgttttgaa 2527381 agtctactgc aaaaggcgtt gagatcgttg cgtccgcacg ccccgatttc agctgattcg 2527441 cagtctcatt tgcgccttgg ccctcatagg caatctcaaa cggccgtcca ttatcctcat 2527501 tccatttttt cagtacaagc gctccgttgg aggttgcact cgtaatcacc cgttttcctt 2527561 ttaagtcttc aattccacgg atcgtatcgt tattttgaag cacagtaatt tttaaaggaa 2527621 aatggttgta agcaaccttg ttaaacagaa attttttctc acgctctttg cttttctcca 2527681 tttgatgtgc cacgatatcg actttatgct gtccgaggct gacaagcagg ttggaaaatt 2527741 ccatcgtttt aaatgtgaat ttataatgtg gcaggcgctt atcaagctct ttgatcagtt 2527801 cgacatcata accggttaaa tcgccttttt catcgataaa gcaaatattc ggaaattggg 2527861 ttccagttcc gaccgtgatc gtctgtacct tcttttgccc ggctcccgtc gtttgactgc 2527921 ctgcaccgca agctgacaga actgttataa gcgaaaataa tattgccatg aatgctgttt 2527981 tcgttttcat ctcatcgccc catttatttt tcaaaacttg attttgaata atctgccccg 2528041 agccattttc ggcttagttt ttttagcgtt ccgtttttct ccagcttttt aatcgcttga 2528101 tccgtgtcat ccgccaaggt ttggctgcct ttattaaaca taaagtacac ctcggtatct 2528161 aataacacgt caccgactgt cttttggcgg aaggcgtgcg ttttattctg aaaatcgacg 2528221 gcaaacggtg tagctatcgt tgcatctgcg cgcccggttt caatttgatt ggcggtatca 2528281 ttgcttccct gtcccgcata tttcaaatga attgggctgc cgtgcgtttt gttgtacttt 2528341 gtaatataat ctgccgcatt tgacgtggcg ccaactatga ctgtttttcc gtgtaagtct 2528401 tttaatgtat gaatcttgtg attatcctct ttcaccgtga tgtacatcgg cgagtagtta 2528461 tatgggactt tatgatacaa aaaacgcttt tctcgttctt tatttttggc catattgtgc 2528521 gcaatcacat caattttttt atttccgaga ctcgtcagca aatttgagaa atccatcgtt 2528581 ttaaattcaa atgtatattg aggcaactcc ttatcgatgg ctttcatcac ttcaatgtca 2528641 tacccggtca attcaccttt ttcatttaaa aacgcaatat tcggaaaatc tgttccagtg 2528701 ccgactatga ccgtttgagc ctgacgatct gttttgttat ttgtttgcga acatcccccg 2528761 ccaagtaatg caaacactga cagcagcaaa accaatcctt tacgcttatt cataggctgc 2528821 ctcacatcat gcccagctgg gcgcacctaa aagcgttggg ttaaatcgtt ccggaatcag 2528881 aaccttgtgc atcatcacac ctatgtcccc gtctttttcc tgctcaaaat acacttcata 2528941 ccctctcctt ctgtacatgt cagcaagcca aggatgcttg cgcgccgatg tgccgagtgt 2529001 cagcgcagga gccttcagca tatctcgaag cactttttct tcaacatacg taagcagctt 2529061 acttccggcg ccttgccctt tatattccgg cagtgtcgca aaccaccaca caaatggata 2529121 ttttgaagga ggcgtctcac tctcccacgg gaacctgatt gtaatcgttg aaatcagctt 2529181 cccatcccgc tccagcacaa tcgctgaatg atgttcaata ttttctgata ccatttggat 2529241 atcagctctc gtggatggcc aatcaatatc cagctgccga atgggctgaa atgcgctgtt 2529301 aaccagtttc aacagctccg atgcatcttc aacagttgcc agtcgaaaaa tatcatcact 2529361 catttttgtc actcctcttc acaaaatata taattcctat ttgtttacta agcttttatt 2529421 gtttatacta taaagcatac tctgatcttt gactaatcaa aaaaagtaaa ccttcacttc 2529481 agtaatttta atgatgaaaa acaggaggga gcacattgga gttacgctca atcaaaacgt 2529541 ttcatacgat tgtaaaattt ggaagcttct ataaagctgc agaaatactc aactactcgc 2529601 agccgacgat atcgatgcgt atgaagcaat tggagcagga tttaggcgta ctgctgtttg 2529661 aaagaggaaa aagcctgcag ttgacaaaag cagggaagct tttttatgaa cgaacaggag 2529721 atcttttgat gcaatacgag gcgcttaaac acaacctctc cgacttaaag gaagaagagg 2529781 caggcattat caacataggg gtttcagagc caaccgccag tctgatattc cccgagattt 2529841 taaaggattt cttaatggat tacccaaaga taacggttaa tatcaaggtt gatgacgcca 2529901 atacctgcag tcaaaagctc ttagacggga cgattgattt tgcagtctgc ggcgagccgg 2529961 agctgattct tgaaaattac taccatccat ttttttatga cacattaaat gtgattgtat 2530021 ctgatcaaca tccgctcgct gagaagaagg ctgtccattt gtctgattta gcagaagagc 2530081 gcttcatatt tacgcccgcc aattgcccca ttcgcttaca aattgaacag catttacata 2530141 gagaactcgg gaatcgctac aaaaaaatgg agctcacaag cagcatgtca catgaatatt 2530201 acgtacgtga aaacatcgga atttcaatct ttaccagcac cgcacattct aaaccgttca 2530261 acggcactaa agtcattcca attctgaacc tggatatcac cccgcccata gggctgttga 2530321 caaatcaaaa agaagttcat tttgaccgcg ccacgaagga cttgatcgcc cggataacca 2530381 aacgttttca gcagcgcagc aaagaattgg aaggaacctc tgataagacc attacaggat 2530441 aactgaaaaa ataaaaacca cctcctgatt catcaggaga tggtttcacg gtttaaagct 2530501 cgatcgtctc accgaccgac atgactttgc cgactccgcc cggcaggctg tcagcgaatg 2530561 cttctgggtc ttgttcgatg accgggaatg tattgtaatg caccggcacg acctgttttg 2530621 cgcgcagcca ttcagcagca agcttggcgt cttcaggccc cattgtaaag ttatcgccaa 2530681 tcggaaggaa agcaaggtcg atatgattca attcgccaat gagtttcata tcagagaaaa 2530741 gtgccgtatc gcccgcgtgg aaaatcgttt tatcttctac agtcagcaaa ataccggcag 2530801 gcatgcctgt gtaagtgatc gttttgtttt cttcatctgt gatggctgat ccatgaaagg 2530861 cctgtgtgag cttcactttt ccaaaatcga actggcggga gccgccaata tgcattggat 2530921 gaacattcaa gcctttccag cctaagtaca cagcgagctc gttcggggct ataaccagcg 2530981 cgttattttg cttggcgatt tgttcagtat caccgacatg gtcattgtgg ccgtgcgtta 2531041 gtaagatgac atccgctttt acatcctccg gctttatatc cgttaatgaa ttccctgtta 2531101 aaaacggatc aaaaataata tgatggtcct tcgtttccac tgtgattaca gaatgtccgt 2531161 gatatgtcac tttcatttct ttcacctcgt cacatgattt tgtttttttt attttccctt 2531221 tttaaaaagc tgaaaaactt atgttgtttg attcttgtta atgacattga ggcctccggt 2531281 ggcttcaatg acagtccctg tcacaaggtc tgagttctcc tcacacaaga aagcgataat 2531341 cctggcaata tcctcgcctg taccggatct tcctatcggc gttttttctt tgccgattcg 2531401 cattctggct tcctctatcg atgcttcttt catgtcgccg acaatgtctc ctgggcaaac 2531461 catgttggcg gttatgccga attcggcttc ttcaatggca attgtcttcg tcaaagaagc 2531521 caagcccact ttcgcagcgc caaatgccga tcggtgaagc cagccgggcg cgtgagccgc 2531581 accttggaat ccgtacgtaa taatgcgtcc aaattgctgt tttctcataa taggaataac 2531641 cgctttgaat aaatgaaaga cggcgcttaa atttccttcc agcatgccat accattcatc 2531701 atcagtataa tcggctaact ttttacgttc aaatatgtat ggtccagcgt tgttaatcaa 2531761 aaagtcgatc cttccgaagc ggtttaaggc agcctctgca atacgcagca gatcttcttt 2531821 tttggtgaca tcacctttta caaattgcag ccggtcaaga caatcgggac aggcttcctt 2531881 caggcggctg actgcctcct catcctgtct gtaattgact gttactgaat acccctttgc 2531941 aagcaacgtt tcagtcactt tgcggcctaa acccttcgaa ccggcagtaa ttaaagcatg 2532001 tcgcacatga atacctccca aagcaacgtc gccgctttca ataaagtgtt tcttcttcta 2532061 ctttactata aaaggcttgc aatatcactt tttacacttt ggcatacaaa aaaagctgcc 2532121 tgtacagaca gcttattctg caggagatga agactcctga tcaggcatat cgacataacc 2532181 gctttgatat gcttctgaaa tgagccttgt tgtctcctgg ctttcttgtt catcataaat 2532241 atagcgttcc ggttcttttt tcatcattct gcctcccatc attatagagg taggttggct 2532301 ataatgacgg gattttatga aggaaatttt aacaaactcc tgctgccacg caagctttcg 2532361 ctttttcaag cgcctgttcc acctgtttga atccggtgcc cccggcgctc attctttttt 2532421 caactgcgta gtaagggtct aacacagtgt aaatatcttc ttcaaatagt gtgctcgcct 2532481 gctgaaactc gccaaacggc atatcgctta aatagatccc tctttcgatg catgtgtaca 2532541 caagtttccc gaccacttca tgcgcttctc tgaacggcat tcctttttta gctaaataat 2532601 cggccagttc cgtcgcgttt gaaaagtctt gttttgttgc ttgcttcatg acgtctttgt 2532661 ttacagtcat tgtttggatc atgcctgtga agatttgcag gctgccctcc accgttttca 2532721 ccgtgtcaaa catgccctct ttgtcttcct gcagatcttt gttgtaagcg agcggaagtc 2532781 ctttcatgat cgtaaacagc cccatcatat cgccgtatac gcgtcctgtt ttgccgcgga 2532841 tcagctccgc catatcaggg tttttctttt gcggcatcat gctgcttcct gttgcgtacg 2532901 tatcgtcaag ctcgatgaat ttaaactcct gcgagcacca taaaatgatt tcttcagaga 2532961 aacgggatag gtgcatcatc agcatactgc tgttgcttaa aaactccaaa atgaagtctc 2533021 tgtcgctgac gccgtccaag ctgttttcat aaatggcatc aaagccgagc agttccgctg 2533081 aataatcacg gtcaattggg aaggttgttc ccgcgagcgc cccgcagccg agcggagatt 2533141 tgttaatccg cttcattgaa tcctgaaaac gctccttgtc gcgctcaagc atccagaaat 2533201 acgcaagcag atggtgagcg aatgaaatcg gctgggcgcg ctgcaaatgt gtgtagcccg 2533261 gcagaatcgt ttcaacgttc gcttccgcct tttcaatcag cgcactttgg aatgcctcaa 2533321 tcagctcgat gatgtggccg acatgattct tcaagtataa atgcatgtca gtcgccacct 2533381 ggtcattccg gcttctgccg gtatgcagct tgccgccaag aggaccgatt tcgtcaatga 2533441 gcattttctc aatgttcaaa tgaatatcct cataatcgac tgagaattcc aatgctccct 2533501 cctctgcttt ttgcaaaagg gtattcaggc cctctcggat tttcaactct tcttctgctg 2533561 tcagaatacc gcattttttc agcatggcag catgtgcgag agaccctgta atgtcttcag 2533621 caactaaatt ttggtcaaat gatatggacg cgccgaactc gtcgacccat ttttccggtg 2533681 ttttttgaaa tcggcctccc caaagcttct tcatgcttta atctgctcct tctttttcac 2533741 gatgctgttc acttttgtcg gaagtcccca aagctcgata aatccgattg ctgcatggtg 2533801 atcaaatgca tcgtcttttg tatatgttgc aagtttttca tcatatagag agtattccga 2533861 tttacgtcct tctacaattg catggccttt aaacagcttc acgcggacaa tgcctgtgac 2533921 atgcttttgc gtttctttta agaaagcgtg cagcgcgtct tttaacggtg agaaccataa 2533981 gccgttgtaa atgatttctg acattttttg ctcgatgatc ggtttaaagt gggctacctc 2534041 tttcaccagt gtcaaatctt ctaattcttt atgcgctttg atcagtgtca tcgcaccagg 2534101 gcattcgtat acttcccggg atttaatgcc gacgaggcgg ttttccacgt ggtcgatacg 2534161 tccgacaccg tgcgcgcccg ccatttcatt cagcttcaag atcagctcag aaagcgagta 2534221 ggaaacaccg tcaatggaga caggcacgcc ctgttcaaat gcaatttcaa tcacttccgg 2534281 cgtgtccggc gttttttcca gcggagctgt taaatcgtat gcaccttctg gcggcgccgc 2534341 ccatggatct tctaaaatgc cgcactcatt ggcgcgtccc cagaggtttt ggtcgataga 2534401 atacgggctg tcaagattga tcggaatcgg aatgccgcgg ctagccgcat attcaatttc 2534461 ttcttcacgt gaccactgcc attcgcgaac cggcgcgatg acttctaggt cagggtttaa 2534521 tgatttaatg gagacttcga aacgaacctg gtcatttcct ttccctgtgc atccgtgggc 2534581 aatcgcctgt gcatcttctt tttccgcaat ttcaaccagt tttttcgcga tcagcggtcg 2534641 agataatgcc gaaacaagcg ggtattttcc ttcatacatt gtgtgggcct gcaaagagat 2534701 aagcgcgtaa tcctgtgcaa attcttcttt tgcatcgatc acgtaggagt ttgtcgcgcc 2534761 gacttcaagc gctttctgct gaacaaatgc caaatctttg ccctcaccga catccaggca 2534821 gcaggcgatt acattatatc cttgctcctg aagccatttt attgcgacgg aagtatcaag 2534881 acctcctgag tatgctaata cgactttttt ctgttctgac atgataaaaa tcccctctca 2534941 accgtgtttc tattttgtat aaaaataaat tatatttaat aaaaatacat tttgtatgta 2535001 tacactttaa caagtacgtt tcgttttttc aagcctttta taaaaaaaac ttcacctaaa 2535061 tttcaggtga agtttcatag tatttattca tttacttgtc ttttctgatt tctctgacca 2535121 catgcgcaag ttcgggaata atcagcttat tcattgccag ctttactgcg ccgcttgagc 2535181 ctggcgttga gaaaacagcg gtatgctgaa tgacgccggc agttgctctc gacatgattg 2535241 cggcagagcc gatatcctct gtataactca gcatcctgaa tatttctcca aagccgggca 2535301 gttctttcga aaacagcggc gttatggctt caattgtgac atcccgatct gctatgcctg 2535361 tccctccgtt taagagtacc gcgtctgtct gttcatccat gcagcccgca agcactgacc 2535421 gttgcaaagc atccttttcg tcttttacaa tttcatatgc ggcaatatga tgaccggctt 2535481 cttctaaaaa tgagatcatc agcttgccgc ttttatcggt ttcatctgtc ctcgtgtcac 2535541 tgacagtaat cactttgcac cgaacgatat cgggagcttc ttgtttatgc tcttgaacgc 2535601 tcattggccc acctctttta tgttttctgt ctgtcactat catgcatcaa caaaaaagca 2535661 cattcaagag aatgtgcttt catgcgattt attttgctaa acgaacaacg tcgcgcgcaa 2535721 tcatgacttc ttcatcagtc gggatgatca tgacttttac tggagaatgc ggatagctga 2535781 tgaaagcttc ctcgccgcgc acgttattaa gcgcagggtc ccagtatacg cccatgaatt 2535841 ctaaaccgcg aagaacgcgt tctctgactt ccacactgtt ttcaccgata ccggcagtaa 2535901 agatgatcgc atctacaccg ctcattcttg cagcgtaaga accgatgtat ttgtggattc 2535961 tgcttgcgaa tacttcaaga gccgtttccg cgcgctcatt tccttctttc gtagcttcaa 2536021 cgatgtcacg aagatcgctt gagaaaccgg aaatgccgag cagtccgctt tttttgttta 2536081 atgtattcag tacttcgtca gccgtttggc ctgttttctc catgatgtat gggatcaggg 2536141 cagggtcgat gtttccagag cgtgtgccca ttgctacacc ggcaagcggc gtaaagccca 2536201 tggatgtgtc aatagatttt ccgccttcaa cagcggcaat acttgctccg tttccaaggt 2536261 ggcaggaaat caggcgcaag tcttttaacg gacggccgag aagctctgcc gcacgctcag 2536321 ttacatattt atgtgaagtg ccgtggaagc cgtatttacg gatgccgaat ttttcatagt 2536381 attcatacgg caagctgtaa aggtaagact gctcaggcat tgtttggtgg aatgctgtat 2536441 caaatacagc taccgcagga acatttggaa gcacttcttt gaacgcttta attccaacga 2536501 tatttgccgg attgtgaagc ggtgccaatt cagaaatatc ttcgatttcc ttaatggttt 2536561 catccgttaa taaaacagaa tcgctgaatt tttctccgcc gtgaacgaca cgatggccaa 2536621 ttccgtcaat ttcattcaag tctttaataa tgccgaattc cgttaactta ttcagcagca 2536681 ttttaacagc taccgcatga tctggaatat cagttacttc tgtatttttt tcgccgttca 2536741 cagaaattgt gaatacgctg tcggcgatac cgattcgttc aactaaaccc ttcgttaaaa 2536801 cggtttctga aggcatttcg aaaagctgaa atttcaaaga cgagcttcct gcgttaattg 2536861 caataatttt ggacatgatt gacgctcctt tatactctgt atcaacaact tcgtttttcg 2536921 tacttttttc ccggtgaata tcaacatctt ctccgaaaaa tatctgactt ttccatttaa 2536981 acattgtcat gtcggctttt caagtcaact tgcgtattga taacgcttac aataagaagt 2537041 cgttattttc agacacattc actataggtt ttgtattgat gaacgcttac aatttgcggt 2537101 ttttccctct gtattttgtg tttcaaagct ggattcaatt cgtcaagtcc ggtcttcaaa 2537161 agcataaata aaagcagctt aggcatcgac ctcatacggc tgtctaagct gcttttaaaa 2537221 cacttacttt tcttttttaa accattcatc aaattgagcc atcatatcaa gcatcgcctt 2537281 ttgattggag aaagacggaa gattcgcaag cagaatttgc cccggcgctt tcgtattctc 2537341 tccttgtttc tgaagcacaa ggatgctttt ggcatgagct tcgtctttaa aaatagattt 2537401 tggcagctgc aacagtgcgt tgatatgaac cttatctttg aaaaactgtt tcagcttgcc 2537461 gctttgggag ctctcaaaca aatgattcgg aatcataaaa aataagtagc cgcccggttt 2537521 ggtatgcttg acgctctgtt caataaacag atgatgagcg aaggaatggc cttcgtcagc 2537581 tttgagctca aacgcttctg ctccttcgtc attcggataa tagccgactg gcagatcaca 2537641 aatgaccgtg tcaactggat cgataaacaa cggctcaagg ctgtcctggt ggaaaagctc 2537701 aagctctttt ttcagaaggt tcgcttgggc ataggcgatc ttcaagagca catcatcaat 2537761 ttcaatgcca aagctgtttg ccgttttttc agacagctgg ttcagcacgg taaacagaag 2537821 gttcccagtt cccagggctg gatcaagaat ggtcagttcc tttttgtccg ccataaattt 2537881 attcaccaaa tagctgatga aaagcccgat cgtatccggc gtcatttgtc tgtttggatg 2537941 cgagatatct ttcattcctt taaggacggc aagctgaaaa gccttgcgta cccactcatg 2538001 ctcatacgtg ccgaattccg ctttttcaag cagagcctga agttgtttgg ttttctgatc 2538061 agcaggcagt ttcagctgat ccgttttttc aagaaaatac atttctcctg cttcggccag 2538121 cgcctctata tatgaaatct gcaattcatt ctttatcata atcgcggctt cgtttaacag 2538181 ctcatacacc gcacctacat ggtctttttg catattgtgt tcctccttgc catgaaaaaa 2538241 gctccggcgg cagcctggag cttttttccc tgcttacttt actaatgcct tagcagcctc 2538301 aattggcttt tcatagttcg ggtggtttgt tgcttcgctt acatattcag cgtaaacgac 2538361 ttttccgttc tcatcaagga caaatacgga acgcgcaagc agacgaagtt ctttaatata 2538421 cacaccgaac gcttcgccaa atgacatatc tctgtggtca gacagtgttt ccactttgtc 2538481 aattccgtta gcgccgcacc agcgcgcttg cgcgaatgga aggtctgcac tgattgtgta 2538541 gacgttgaca tctccaagct ttgcagcttc ttcgttaaaa cggcgtgttt gtgcatcaca 2538601 aacacctgta tcaattgaag ggataacaga aataatcgtt acctttcctt tcatgtcagc 2538661 taacgatttt tcttcaaggc tgttagtcag cactgtgaaa tcaggagctt gatctcctac 2538721 cttcacttct tgtccgacaa gtgtaaccgg accgcctttg aatgtaattt cagccattat 2538781 aattcctccc ttttgtatgt atgtctctat catagtaaag tttcctgcaa actgcaaagt 2538841 ttatgccaaa aaaaagttaa ctgcggccag cgcagttaac ctttttttaa taattcatat 2538901 tgttcatttg gttttgattt tggccttggc tttggttttt gttatttttc ttgaacattt 2538961 gctggatgcg ctcgagtgtt tgaggggctg cgtctaaaat tttctctatt aaatgggtat 2539021 tttcatctaa atgaagcatt ctgatgcctg tcgatccgac aattaaaaac gcgatcggcg 2539081 taatggacac accgcccccg cttccgcctc cgaaaggaag tttctgttct cttgtctcat 2539141 cgtcttccga tttcttttcg gccggctttc cgccaaactc gcttccgcct gcggcgaatc 2539201 cgaatccaac tttagaaaca gttaaaatca cacttccatc aggcgtttcc actggatctc 2539261 cgatgatggt gttaacatca atcatttcct tcaagttttc cattgcggtt ttcattaaac 2539321 cttggatggg atggtctgcc atatacgctt cctccttaaa ctgatgaatc attctttgaa 2539381 gtcattctag ccgacggatt cttctttaat acggatagct cccgtccgta tttgacgaat 2539441 ttgaaagctg caagcatagc atgtccaaag cgaaaaaaga atatacactg aaaatgggtc 2539501 ttggaaacag ggacttgaaa cgacgggatc acctcataga caggtttatt cacaaagtcc 2539561 aggtggtcgt agagcattgc tgcgataccg cccttcacgc cccatacagc accggttaac 2539621 acacctgtca ctgccgcgtc ctgaattccg attactgtaa cccattctag ttttgtgata 2539681 tgtaaatgcg cgagaaaaga cgcgctgatt ttccgcagtc tggtgacctg atgcaaaagc 2539741 atttcgattt tattaatgct ttgctgcaca tcgttttgtg taattttttt ctttccgctg 2539801 ctttttttca ttttggattc agttttttgt ttgatatcca ctgttccgtc ttctttgttc 2539861 accttaatcg ccgggattgt ttttttgatc cttataaggc caaacagcgc cgtaatcttc 2539921 aaggtcaatt tgtcattatc atcggcatga agatactcca gcgcgacatg gattttcatt 2539981 ctgagaagca gtacgatccc tatgagaata agaatggctg tcagtacata caccatattc 2540041 ttcacttcct ctaggagcat tatcgccaat tcctaaaaaa ataaacccgg acggaagtcc 2540101 gggttatcgg ttatttgcgg tataattttt catgcaccac ggtggtatcc gcgatgtaat 2540161 catgaatccc ttgttttgta ggtgaaaagg caacaacgat atataaaatc caaatcttat 2540221 caatataccg tccaaccact tcacgaaaaa tcactgtact ccatgtcagc ttgctatctt 2540281 gcttcacaga aaccactttg aggccgaaca ccattttacc aagcgtctgc ctgaagtatt 2540341 ttgtcatgag tgcgaaatag gcaagataca caataagcgt tgtcacactg taggccgaga 2540401 aggtaaacat gccggatgtt ttcggcagat ccaatacggt aaagagggga gaaacgagca 2540461 aatggtttaa tccccatatc acgagccaat caagcaggaa agcccagaaa cgaacccaaa 2540521 agccagcata ggcatgtgtc agcagctccg cttcttgcgg gcctttgatg tcattgcgct 2540581 ctaactcttc atatgtcgcg tccattattg ttccctccta cttcgcatag agatacatca 2540641 ttctcggcga accggattgc gatagaattt ctctcatatt caaaaaatca atttcacttt 2540701 taaacatttt gttcgcgccc atggaaaaca gtgagcctaa tccgaagctt tcctcataag 2540761 aaatgacaga ggcgtttttc aaatccttgt gatccttttt catggccgta atggtatcgt 2540821 cataaaaacc aagctcatca acgaggttca gttttttcgc ctgccgtccg tcatacacgc 2540881 ggccgtccgc aattttcttt acctctgctt tcggcatgcc gcgccctttt gaaatgacat 2540941 caacaaagcc ttcatacgaa ttatcaacca tcgattgcat gatgtttttt tcttctttcg 2541001 tcatctcacg ggaaggagac ataatgtcct tatgggcccc gctcttaatc gtttcaaaag 2541061 aaatgccaag cttgtcggca agctttgaat aattgacgct ttccataatg acgccgagtg 2541121 acccggtcag ggtttccggt gtcgcaaaaa tcttatcagc cgctgttgag atgtaatagc 2541181 ctcctgatgc tgccatcgaa cccattgaca cgtaaatcgg ttttttcgtt tctttcttga 2541241 tttcttccag tttcttatgt atttcagcac tttcatacac tccgccaccc ggagaattca 2541301 ccttcagaac gatacctttg accgtcttgt catcttttgc gcgctcaagg ttttttaaga 2541361 acgttctgtg gttatatccg tctgcaccaa gcagactgct tgagtcccca ttatcctgaa 2541421 tggtgccgct gacctctaat acggcaattt tacttgaggg actgccgttt tccagcgtct 2541481 tctcctgcga ttcatccgtc agtgatgtga gatccgtttg agcgcctttg acgctttcaa 2541541 agaaactcat agagatgctg acgataatag acacgccgaa aatccccaga gcaatcacta 2541601 atgcaatcca tctttttgca ttcatttttt ctcctccttt ttcctaaact ctctcattat 2541661 acgattcaat atgaaaaatg tttcacttca tgagaaagct ccggcttaac gggctgccgg 2541721 caaacgtggt acacttatgg ccaaaggtat tttatcacaa atactggatg gcagaaaaac 2541781 ttaaatatga cagcaaaggg gaaatgggat atgaccgatc aacgccgtaa tgtttatttt 2541841 tttcacaaac aggatcagga aacgaacgaa caagcccgct cgttaacaca attagcggaa 2541901 gagcatggat ttaccgttgt gaaccagcac tcagacgcca atattatcgc tagcattggc 2541961 ggggacggca catttttgca ggcagtcaga aagacgaatt ttcgtgacga ctgcttgtac 2542021 gtcggcatta ccaaaaaggg gaaagctcat ttatattgcg actttcatag tgatgagcga 2542081 gaaaaaatgg tcgatgcaat gacgtttgaa caaattgaag tgagaaaata cccgctgatt 2542141 gaagtgacag tggatcaagc cagtcctttt cactgcttaa acgaggtatc catccgctca 2542201 agcatcatca aaacctttgt gatggacgtg ctgattgacg atctgcactt tgaaacgttt 2542261 agaggtgacg gaatgattat ctcaacgcct acagggagca ccgcctataa caagtctgtt 2542321 gcaggagctg ttgttgatcc attgcttcca tgcatgcagg tatcagagct tgcatccctt 2542381 aacaataata cctaccggac actcggctcg ccatttgtcc tcagctctga ccgaaagctg 2542441 acccttcgtg tggtgcagga cggcaacgaa cacccaatca tcggcttgga caatgaagca 2542501 ctcagcacga gaaatgtgaa aacgatcgaa atcaaactgt ctaataagaa aatcaaaaca 2542561 gtcaaactaa aggacaattc attttgggaa aaagtgaagc gtactttttt atagaaaata 2542621 aaaggacagg ctgctgcctg tccttttatg atttctcata tacaatctgg ccgttaatca 2542681 cggttttttt aatctctaaa agatgaagct gtgcggggtc aatggcaaac ggatcaccac 2542741 tgagaactgt aaaatccgcg tcatagcctt ccgcaatttt tccgcgtgac ttctctttat 2542801 aaatgatacc ggcgctacct tctgtataaa gctttatcgc ttcatataca ggtaaacatt 2542861 cactttcatt atagcttggc ccgttttgct catgactgct tttccggagg accgcggact 2542921 ggatccctag aagcgggtca acaggctcaa tcggggcgtc tgaaccgccc gcgcataaaa 2542981 tgcctttaga tatgagggtt ttccaggcaa atgcagtctt catccggtct tttccgagac 2543041 ggtcaatgac ccacggaaag tcgcttgcaa cgaagtgcgg ctgaaggtca agtgcgatcg 2543101 gcatgcgtgc tgctctctcg attaattcgt tatcaagcac ttgagcatga ataagccgat 2543161 catgccggcc gtttttgggc ggatgctttt ctattgcgtt cagcactttt tcaaaagcaa 2543221 gatcgccgat tgcatgaaca gcaacctcca tccctttttc tctcgctttg cgaatgagcc 2543281 ggccaagggt ttcgtcatcg tgaacctgaa caccatttgt tgatggatca tcctgatatg 2543341 gttctttcaa taaagccgtt ctcccgccaa gcgccccgtc cgcaaagatt ttcatagcac 2543401 cgaactccac atacgggccg gacagcttct ccagctgctc ccatcgatcg acagcttcat 2543461 gatgaacgag caaatggcag cgaaacggat actttccgcc agcggcagct ttctcataag 2543521 ctttcatcgg caccgaaaca tcaccataat aggacaagtc ttccgaatga ccgcccgtca 2543581 ggccttttgt ccagcaatcc tttattgcag ccgttaatgc ctcatcaaca tagtgctggg 2543641 agactggcgg gacagccttc agaatcaaat cctgcgcctt atcaaacagg agtccggtcg 2543701 gctcgccatt tgcatctttt acgatgactc cgccgtcagg atcaggagta tttcttgaaa 2543761 ttcccgctgc ttgaagagcc gcagaattga cagctattgc atgccggcat atacgcttga 2543821 gcaagacggg cctgtcagga aacaggcgat caagatcatg cttagtcaag tagtcaggtg 2543881 tctcaaactg attttcattc cagccttctc caatgagcca atcgttttta ggaagctgcc 2543941 gctctctttc cttcgcagcc tgtaaaattg aatctttcga cgtcagtgcg gacagatcga 2544001 gctgaagctg tttctcaccg tggccgatca aatgtagatg gctgtcaaca aaaccgggga 2544061 acatcactgc tccgttcagg ctgatttctt ctgtttccgg cgacccgtac ttttccttca 2544121 aacgttcata gctgccggtg ccttttataa caccatcctc aacataaact gcctcagtcc 2544181 gatcgccttc ttcgagcatc gtataaatga aaccgccgtg ccatatcgcc ttcattcacg 2544241 ttcactctct ttctttacgc ctttttattg gctttgagct gttcttcacg ttttcttaat 2544301 tccactcgtc tgatttttgc agaagccgtt ttcggcaggc tttccacaaa ttcaatttct 2544361 ctaggatatt tgtatggagc ggtaatcgtc ttcacatggt tttgcagcat tttgacaagc 2544421 tcatcactgc gtttttcatg attttgcagg acaacatatg cctttacgat ggagcctctg 2544481 atttcatcag ggcttgcgac aacagcacat tcttttactt ctgggtgctt aacaagcgcg 2544541 tcttccacct cgaaaggccc gatcgtatag ccggagctga taataatatc gtcatttcgg 2544601 ctttcaaacc agaagtaacc ttcctcatct tttcttgctc tgtctcccgt taggaaataa 2544661 tcgccgcgaa tttgtgtttt cattctttcc ggatctttaa aatactcttt aaagagcgca 2544721 ggcgtactga ggtgaacagc gatatcgcca acctcaccag gtttgcagat ttcaccgtct 2544781 tcatttatga tctccacctg atttcccggt gtcggttttc ccatgcttcc cggtttaata 2544841 ggcgtatctt tcaaaacacc aaccaaaagc gtgctttctg tttggccata tccgtcccgt 2544901 accttaatgc caaagtgctt ttggaaaaca tcaatgactt cacggttgag cggctcacct 2544961 gcggaaacag cgctgtgcag ggcagaaaga tcaaagcgtt tcaagccttc aaccttcgcc 2545021 attaagcggt attctgtcgg agtgcagcag aaaacattga ttttgtagcg atttaaaagc 2545081 tctagatatt tttctgcttt gaatctgccg tggtacacaa aaccggttgc tccgctgcca 2545141 agcaccgcta aaaacggact ccatacccac ttttgccagc caggggcagc agttgcccag 2545201 acgatatcct tttcagaaat gtcaagccaa gcgccggcag aagtttttaa atgagcaaat 2545261 gcccatccat gtgtatgtac aacacctttc ggctgacctg ttgtcccgga tgtataagat 2545321 aagaaagcca tatcatctct tgttgtgtca gctgttttaa attggcttcc gtccgcttca 2545381 attgataaga ggtttttcca gccggcatca ttttcaccaa tagacagtgt aatcagtttg 2545441 tcagccgtac tgacatcccg gaaagcgcca ataaattcgg agtagacgat agcgcctttt 2545501 acctctgcat gttcaatccg gtattcaaga tctttcgcgc gaagcatttc ggagcacgga 2545561 atgacaacca ttcctgattt caggatagcc aaataaacag cataggcttc aagcacccgc 2545621 ggaaccatta caatcagctt gtctcccttt ttaaatccaa gatcagctaa ggccgctccg 2545681 attttatttg tttcttccat cagcttttca tacgaccaag attcttgctt gcccgactcg 2545741 tcctcccaaa gaagagcggt tttttgtcca gcagcactga acttttccat ttcattcact 2545801 aaattatatt gcacaggggc aattaaatct tcacgtttta acacgaacaa ctcctcactt 2545861 tctccaccca ttatacataa atacaggctc tttccgtaag gatatgccta aaagcaacct 2545921 ctgtaaacat agattttata ggccgctggt ccttttttat atgtaaaaaa tgaaaaagag 2545981 tggggatacc cccactccta agccattatg tgaaattgta aattagaatt gtcctccgcc 2546041 catgttttgt tgagcaaaag atacaagacg ttttgtgatc tctcctccaa cagaaccgtt 2546101 agcgcgagaa gttgtgtctg ctccaaggtt tacaccgaat tcagaagcga tttctaattt 2546161 catttggtcg atcgcttgag cagctcctgg tactaaaagg ttgttgctgt tacctgagtt 2546221 attgttagcc atgtgtctca cctccttgtg agtatagaat gtgtcaaaac acatggcttc 2546281 attcagaaaa actttggtaa ttgtatacag gagctgaaaa ttgatttaaa agagttcagc 2546341 gaatttatcg ttagcttctt gttcgctata aagggtcatt gtctcaatgt tatctaccgc 2546401 ttcttgaata tacggctcga aatcaacaaa gctttcaaag tgttcaattt tctctttttt 2546461 agggcgtgtt ttcgggcttg gcggtgtaaa gatcgtgcag cagtcttcaa acggctgaat 2546521 acttgtctca tatgtgccaa tttcccgtga tttttcgatg atttctgttt tgtccatggc 2546581 gattagcgga cgcaaaatcg gtgttgacgt caccgcatta attgcataca tgctttcaag 2546641 cgtttggctc gctacctgac cgaggctttc tcccgtaata atggcaagcc cgtttctctt 2546701 ttctctgatt ctgtcggcta tctgaagcat gaggcggcgg gttgccgtca ttgtgtaatt 2546761 ttcaggaatt tgtttttgga tgagctcttg cgtttttgta aatggaacaa tatgaagtgt 2546821 catgcttccc ccaaaacggg acagacattt cgccagatcc attacctttt gctttgcgcg 2546881 ctcgcttgtg tatggcgggc tgaagaaatg aacagcttct accgacaatc cccgtttcat 2546941 cgcataaaaa ccggccacag ggctgtcaaa accgccagaa agcatcagca tcgcttttcc 2547001 tgctgaacca actggcagcc cgcctgcacc tttttcatca cgaattgtca aaaatgttgc 2547061 ttcttccctg atttcgattc tgagcgggat gtctgggttg cgaacatcga ccgtcaatcc 2547121 ttctgtattt cgcaaaatat ggccgccgat ttcagcgttc atctggtttg tatctaattc 2547181 aaattgctta tacgctctct ttgtcgcgac tttaaacgta tcacctggtt tatactgatc 2547241 tttgatagcc tttagtgcgg ttgccttaat atcatcaagg cggctgtcac acttaattgc 2547301 caggctgaag ctttgaatcc caaacacttg ctttaaatga ggaaaaagag cctcaggatc 2547361 ctctccattt aatgtaatcg tcatacgatc cctgttggaa aagtatttta aattcggata 2547421 gtctttcaaa acgagtctga tgttttgttt taagcgctca ataaagcttt ttctgttttt 2547481 gcctttggtc gaaatttccc caaaacgaat taatatatga tcgtaattca tgttctacct 2547541 catcatttcc cttaattttt tgatgccagg acgaagcgcg ttcataaacg gttctgccac 2547601 atcgcttgtc tggctgtaat ttaaactgat tctgatgctg cttccggcaa tctgctctcc 2547661 tttgcccatc tctaagagaa ccttgctggg cttatgttct tttgccgagc aagccgatgt 2547721 tgtggagacg aatatatcct gttcctcaag catgtgtaaa agcacttccg ctttaatccc 2547781 cggtacagag aaattaataa tgtgcggcgc gctattcatt tgaggcgtgt tgataacgac 2547841 gccctcaatt tcactcagcc tattcataaa caattccttt acggcagtca tcgtgtcaag 2547901 ccgtgtgtca aaatcagcag aggccagatt aatggccttg gcaagcgaaa ccgcaccagc 2547961 agtatgttct gttccggccc gtatgccttt ttgctgagag cctcccgtta tgagcggaat 2548021 aaggcgtgtt ccttctttta caataagtgc gcctgtcccc tttaggccgt gaaatttatg 2548081 ccccgaaatt gaacatagat caatgccggc cttttcaatt gccaagggca ctttatagat 2548141 gccctgcaca taatcgacgt gaaacaaaat gttcgaatgc tctttcagca cttctcctgc 2548201 cgcttcaatc ggctgcacgg aaccgacttc attgttcaca tgcatcatgc tgacaagcac 2548261 ggtatcggga cggatggctg cttttagatc ttcaatagaa acaaatccgt cttcattcac 2548321 agaaagataa gtgatatcaa acccgaacaa ctctttcagc tgttctaacg attccgtaac 2548381 ggatggatgt tcaatagaag tggcaatgat atgtttgcct gtttttatct ttgacaaagc 2548441 cgctcctttt aaagccgcat tattggcttc tgtggcgcct gacgtaaata caatatcata 2548501 tttttttagg cctaaggacc ttttgatttg atttttggct gcttgaagca gctgttccgt 2548561 ttcggctcca tatcggtgca aagatgaagg attgccaaag tatcggctgc tcgtctgttc 2548621 atatacgttc aagacttcat cgtaaggctt cgtcgttgaa ctattatcta aatatatcat 2548681 cttttttact cctttatgaa agcggtacaa ggtatgatat ttatgttacc ataacaaaat 2548741 ttaatagaaa attacgaaaa actagtattg acttctaatt tttttaccat ataataagat 2548801 ttgttcgttt cgtcatatta tctgacaatt aattgacaga atattttaac ataattatta 2548861 ggaggatttt tttcatgaaa cactcactgc ctgtcaaaga taccattatt attggtttca 2548921 tgctatttgc gttattcttt ggagcaggaa atatgattta tccgccggaa cttggacaag 2548981 cagccggaca caacgtctgg aaggccatcg gcggattttt actgacaggg gtaggcctgc 2549041 cgcttctcgg cattatcgcc atcgcattaa ccggtaagga cgctaaaggc cttgctgaca 2549101 aagcgcaccc tgttttcggc acaatcttta ctgtcgtgct ttatttatca atcggaccat 2549161 tattcgccat cccgagaaca ggaactgttt catatgaaat tggcgctgtt ccgtttttga 2549221 ctggtgtacc agaaagactt tctttattaa tatttacact tatctttttc ggcgttacgt 2549281 actatttagc gttaaaccca tctaaggttg tggatcgagt cggaaaaatt ctgactccca 2549341 tcaaattcac aattatttta atcattgttc tcaaagccat cttcacgccg atgggcggat 2549401 tgggcgccgt gacagaagca tataaaggaa caccggtttt taaaggattt ttagaaggct 2549461 ataaaacaat ggacgcactt gcttcaattg tatttggcgt tgtcgttgta aatgctgtaa 2549521 aaagcaaagg cgttacacag tctaaagctc ttgctgcagc ctgcattaaa gcaggtgtga 2549581 ttgccgcttt aggcctgact ttcatttatg tatcccttgc ttatttaggt gcaacaagca 2549641 caaatgccat tggtcctgtt ggtgaaggag ctaaaatttt atctgcgtct tcccattatt 2549701 tattcggttc attgggcaac atcgtactcg gagcagcgat tacagtcgca tgtttaacaa 2549761 caagcatcgg ccttgtcaca tcttgcggcc aatatttttc aaaacttatt ccggcattat 2549821 catataaaat tgtcgttacg attgtcacgt tattcagctt gatcattgcg aatttcggac 2549881 tcgcgcaaat tatcgcgttt tctgttccta ttttatcagc tatctatccg cttgccattg 2549941 tcattatcgt tctttccttc atcgataaga tctttaaaga aagacgcgaa gtgtacatcg 2550001 catgcttgat cggtacagga cttttcagta ttttagacgg tatcaaagca gccggttttt 2550061 cacttggatc tttagatgtg tttctaaatg cgaatcttcc tctttacagc ctcggcatcg 2550121 gctgggtgct tccaggaatc gtcggagcgg ttatcggcta tgtgctgacc ttattcatcg 2550181 gaccatccaa acagcttaat gaaataagtt aatgtcacag aacgcctgcg ttattgcgca 2550241 ggcgttttgt aataaaaaaa gagcctgctc attacactgc gggctctttt tcatggtcgt 2550301 gattatctaa gcggatatgt cagctttgat tttttcaact gcacctggcg cagccttttc 2550361 tacagcggca gcggcaattt cataagagtc gtcataatca aaagcataaa aacgtctttc 2550421 cgcttctttc agctgttcag ataaaatatg attctggctt ctgaaccggt ttccgaactg 2550481 aatgattttt tcaatgagga tgacctgctc gacaagttcc tctgattccc ggcttgccct 2550541 gttgacgata tcttctgctt gtttcaaatg ggctccggct tcttccatat ttaatggaag 2550601 ttcgtttagt tgattgaccg tttcttgaat atgatgatgc gcgttctcca gcatctcttg 2550661 aatatggctc ggaatgcctg gaatgttgct agtcttcagc agtcttgctg tctcagaaat 2550721 tgtttttttc aaattgctga gcgtctccct cgcctgaagc tcttcttttc tcagcgcttg 2550781 cagattttca cgatactcgg catgctcttt tttcacttct tcaatttgct tctctattga 2550841 agcaacttct tctactaaaa gtgagtaggc gacatgctct gcatcaagct tatctttaac 2550901 ggatgatagc agctttccaa tttcatcaag gcgcttttca aaagcctgct gtttgccgag 2550961 ctcaccggct gtcagcctgt agctttcctt caccagctca gtttccgctt tcgtatgctc 2551021 tttctcttct ttaagcttgt cgtaagcaat aatcaattca ggcattttgc ttagtacgga 2551081 ttgaccggct tcaacttcgc cctccagctg ctgataaaca gattgaatat tttcgtcaat 2551141 gagctgcagg attgcggacg cttcatcaat atccagttca gtcatcagga catgttccgc 2551201 tcgtttcagc tggtttgaca gattttctaa ttccttatca agctggatat gctcaagctt 2551261 gtaccctttt tctttcattt cgccatagcc atccttgagc tttgcaatct gtccgggcac 2551321 cgtctgttta cagtcagcta acagcttcgg cacatcatct atgtatgact gaagccgttc 2551381 aagattgcgg tcctgctcaa gcagtacttt tcgtgcagta atatagtttc cgccttctgt 2551441 ttcttcttca aattgtttga tgccgctcca aatttcgtcc agatcctttt caaggctgtc 2551501 ataaagctcc ccgtaaaggt ggctgtaagc cagcaggttt tttcgagatt tcgaatagcg 2551561 ctccctcacc tgttcaatct cttcacggct cttttcctca cttgtgacaa gatcgctgat 2551621 ttcccgaaga atcttttcaa tgcttgattc agccgctgtc agcaggtcgt cgatatgaac 2551681 gagcacttga ttggcctttt taaaccggta tttgtctgca ttttcctcgg catcataaag 2551741 gagctcttca actttcggca tgtgggctgt gacaatctca tcccattctt cacgccactt 2551801 ctcaaagaac tcttctgtct gacccgtcat ttttaaatgt tttattttag acatttcttc 2551861 cacgatcgac cgattcagaa tttcaatctt ccacgattcc agccggtcga tttcggcgta 2551921 gatttttttc ctgaaaaagt agcctgccgc aaacagcgca agcagtacaa ttaataatcc 2551981 aatgacaaac tccataatga gcccccttgc tgtttacctt aatctgtcag ggtgttttat 2552041 ttattcagaa agatttcagg atatgtattg agaaaaactg tcgttttcat tgttattatg 2552101 ataccatgta acaaacattt tttgaccaga aatcaaaaac tttttgtgca aaatcggcag 2552161 gatttgacta ttttttcatg gggtgacatc aatgcaaaag cgagacggac atattcacac 2552221 accattttgc cctcacggct ccaatgacac actcagacaa tatgcagaag aagccttaaa 2552281 aaaagggttc gaatcgatta cttttaccga acacgcccca ttgccgccat cttttaccga 2552341 tcccacgccg ctgaaagaca gcgcgatggc gcaagcttct ttggaacgct atattcatga 2552401 aatttccgga ttaaaaaaag aatatcgcgg acagcttagc atacggacag ggcttgaagt 2552461 cgattatatc gctgaatttg aagacgaaat tacattattc ctagacacat acgggccata 2552521 tttagatgac agcatcttat ccgttcattt tttgcgcaca gactcttcct atctatgcct 2552581 tgattatgac gagcatacct tcaaagagct gatttcagcc tgcggaagca ttgaagcggt 2552641 atatgaacaa tattaccgga gtatctattc ttccattgta gcatctctcg gcgtttataa 2552701 gccaaaaaga gtcggtcaca tcacactcgt ccaaaaattc atcaagctgt ttccatacag 2552761 catgtcagag catattcgcg gcctcgtttc tctgtgcctg aatgccattg aagaaaacgg 2552821 aatggagctc gacttcaata cttccggctt aagaaaaact tacgctggcg gtatttatat 2552881 cgaggattgg atgctgaatg aagcgaagca aaagaagatc ccgcttgtgt ttgggtctga 2552941 tgcccatcaa gcgggagatg tcggatatgc gtatgaggcg tttttggaac ggtgctagtt 2553001 ggtgagcgcc acgtctcctg tccggaagac gcttctgatc caaatcttga tttcttcaaa 2553061 atacatttta taaaaatacg gctcgtgcgg ctgcatgtag agtacttctg aaatatattg 2553121 aggctggaga tagggcatca tcaagagaga ttttaattgg agaataaaat gaggcagcgg 2553181 cagcgttaaa tattcacgct gtttttctcc ttcctcaatg atcagctgga agatatactt 2553241 ttccttcatt agatatgtcg acataatttc cctgattaat gtggagtcaa ttgtgacttc 2553301 ccggtagaca aaacgagtta attgacgatg attatgctga taggataaaa tatcgaaaac 2553361 caattgaaga agctgttcct gcgtgctttg agtagagata ttgcttgccg ctgtttcaag 2553421 cgttttgctg tagccttcgt aaaactctga aactaagtgt tccatcaagc ctcctttgcc 2553481 tttaaaatag taggagatgt gcgcaacatt tacatcagct gactttgcga tttcacggac 2553541 agacgtgcca gaaaatcctt tttggttaaa aagcatgaca gcagattcaa taattttgtc 2553601 tttggtgctt actttcatac ggctcactcc ttcctcttga tactattcaa gcagaaagcc 2553661 gctgttcctg taagaactta tcgacaaatg ccggcagaaa agccggaact ttgttttata 2553721 ttatagaaaa agtgagggtt ttccatgttc catgtcgaaa aacaatctgg agataaagaa 2553781 aaagactatc agcttctgct aaaacagctc gaagccatga ccgaagacga aacagaccaa 2553841 atagctaact atgcaaatgc ctcagcactg ctgtatcatt cgctgcctga agtcaactgg 2553901 gcgggtttct attttgccaa agaagaggat ggacagcttg tgttaggtcc gttccaaggc 2553961 ctgccggcat gtgttcggat tcctttcggc agaggggttt gcggcacagc gtacgcaaac 2554021 ggaaaagtgg aacgtattga ggatgtaaac gcgtttccgg gacatatcgc ctgcgatgca 2554081 gcgtctcaat cagaaattgt gcttccgatt cgtgtagacg gaaaaattgt cggcgtcttg 2554141 gacatcgaca gcccagtgaa aaaccgtttc gacgaaattg atgaaaaata cttaactcaa 2554201 tttgccgaaa cgctagaaaa agcgttagcg cagtaatata aaagcccaaa actgatatcg 2554261 ttttgggctt tttttatttt attgagtcat gaatcatcaa gcggtttttc ccgctccgtt 2554321 tcgcgctgta gagcgcttca tctgcctcat gcacaagctc tttcagcgac ttttttgttt 2554381 ctgtcgtcca gcaggagata ccgcaggaaa tggttacctc gggtttcgta ttttttctga 2554441 ccgcgtaaac cagtcgctcg gtaatccgtt tccccactgc aaccggcaca tttggcaaat 2554501 aaatcgccag ctcctctcct ccccagcggg caccgacatc atgctttcgg atgttgcttt 2554561 taatcactga agcgacttga attaaaatct cgtccccagt ctgatggccg tacgtatcat 2554621 ttacattttt aaaattatca atatcaacaa gaataaaaac acccttttga tggattttca 2554681 tgctgtattg aattttttca tctaaatacg ctcgtgaata cagttcagtc agctgatctg 2554741 ttttcacgag atgctcaagg cggtcgcgaa gcattgaatt ggttacagcc agtgtcgcgt 2554801 gatgaatcag cgcctgaaac agcttgtaca tttcaaatgt aaaagcgtac agctcctgtt 2554861 tcaataaaac cgcaaagcct aaaagccggt cgttttgaat catcggagca gccatcagcg 2554921 agccgtaccc cgccttccca aaaacagact ggccattccc gatgaaaacc cctttttcac 2554981 cttcatacag cttttctttc agctcattat aaaaatctga cggcttcgct tctttaaaaa 2555041 atgctgtgct gcctgggagc aatgttaggt tttcaaaatg gtctatatga aaaaatccca 2555101 cttcttctgc ctgaaacgat tctgccattc tcacagccag atcattcatt gtatcagtca 2555161 atgtcagccg ctgattcagg cgtcgtgatg tttcattaat caattccaaa tttgcgatgc 2555221 ttgctttgga ttgttcgtag agctgggcat tttcaaacgc ttttcccgcg gcgtttgcta 2555281 acagcgacat ttcatcaagg caggcatcag taagaaagct gtcacccgtt ccttcagcct 2555341 tcaacacccc gtatgtgccc tgctgtcctt tgatcggaat ataggcgaca gattcatttt 2555401 tccgcaaaat gtctccggac aaatacactt tgagcgcaaa ggaatcggat ttttcccctt 2555461 ccatatacag ctcttttgca ggaatcccta aacattggtc ttgatcgtgc gatataaata 2555521 aagaaaactc aaaaagagaa aatgtgcttg tcaagctttc taaaagctgc ttcagcacat 2555581 ctgtctgatc aagcagtgaa tggaacagct ctgtcatttt gtatatcttt ttttggtaga 2555641 tcgttttgtt atagagtctt tcctgtttca tcgactggtt taaaaatgaa gcaaccacgt 2555701 ccggaagccc ttcaggaatc tcttcatcct gcctgcacgc aagatggaaa cgcctgccgg 2555761 agccgtcctc aatcagataa catgaagcgt ttatttttga agcggaaaaa cgcgcttcac 2555821 catctgccag ttttgtcaca aagtctgatg gtgacggtgt aagcgaaaca caaagggttg 2555881 aaaaataggt ttgaatagcc gaagtcagcc atatgaaaga gtcggtgaat gtgacttttt 2555941 cagatttggt taataaaaaa tcgagcatat gataatgaaa ggcggataat tgatctttag 2556001 tttgttctac catgttttta tcacctaaaa gtttaccact aatttttgtt tattatatca 2556061 taaacggtga agcaataatg gaggaatggt tgacttcaaa acaaataaat tatataatga 2556121 cctttgtgtg aaatattgca gcctttttgt tcagcttcta tgttttcatt ttgttcctta 2556181 tcaataaggt gtatcgtgta actctctgct gctggagcga ggatacatga aaacaaaatg 2556241 tgcatggtcg aatagagcag acggttttta ttttccacaa aaataaaacc aaaggaggag 2556301 tcacattatg gctcgctata caggtccatc ttggaaactg tcccgccgtc taggaatctc 2556361 tcttagcggt acaggaaaag aattagaaaa acgcccttac gctccaggtc cacacggccc 2556421 aggacaacgt aaaaaattat cagaatacgg tttgcaattg caagaaaagc aaaagcttcg 2556481 tcacatgtac ggtgtaaacg aacgtcaatt ccgcactttg tttgacaaag ctggcaaact 2556541 agctggtaaa cacggtgaaa acttcatgat tcttttagat tctcgtcttg ataacgttgt 2556601 gtacaagcta ggtttagcac gtactcgccg tcaagctcgc caattggtta accacggtca 2556661 cattcttgta gacggaagcc gcgttgacat cccgtcttac ctagtgaaac ctggtcaaac 2556721 aatcggtgtt cgcgaaaaat caagaaacct ttctatcatc aaagaatctg ttgaagtgaa 2556781 caacttcgtt cctgaatacc ttactttcga cgctgaaaag cttgaaggta ctttcactcg 2556841 tcttcctgag cgttctgaac ttgctccgga aattaacgaa gcgcttatcg ttgagttcta 2556901 ctctcgttaa tcgttttaaa aacccctgcc gctatgcggt cggggttttt ttatcggctt 2556961 tcgcctcttg ctggccaaca ctatcttgcg cctgctgctc ccaatgatcc cgctgcagcc 2557021 gttcttttgc aatcgtacac atgagattca cgctttagcg ctcctttcat ttaaaaggtg 2557081 gtgattggtc gtgtttgccc tatctaatat actcttttcc tttcattcct atgcggtaaa 2557141 caaaaagatc ctttgccttc agtggcaaag gatctttttc ttatttatac gtcacaagga 2557201 agtatttttt cttcccgcgg cgcagaacag taaattggtt ttcgatgcgg tcttcacctg 2557261 atagggtata atttatttcc gtctggcgtt caccgttaat gtaaacagct ccgttttgga 2557321 tgtcttcacg cgcttggcgt ttagaaggag ataatttaga ttgcaccaac acatctacaa 2557381 gtgaaagctc ttgggtgctg tcaacttcca tagaaggaac atctttaaag cctactttta 2557441 cgtcttgagc agaaagctct ttaatattgc cgctgaacag cgcttgggag atgttgatgg 2557501 cttgctccag cgcctcgcgt ccgtgaacaa gtgatgtcac ttcttctgcc aggcgttttt 2557561 gcgcttcacg tttttctggc gccgtttctg ttttttcagc gtatgcttca atttcctctt 2557621 ttgaaaggaa cgtgaagtat ttcaagtatt tgacaacgtc acggtcgtct gtgttgatcc 2557681 agaattgata gaattcatat ggcgatgttt tttctttatc aagccagatc gcgccgcctt 2557741 ccgtttttcc gaacttcgtg ccgtctgctt ttgtgacaag cggaatcgtt aggccaaacg 2557801 cttttgctcc ttcttcttct gattttctga tcagttcaag acccgctgtg atgttgcccc 2557861 actgatcgct tccgccgatt tgcagtttac agtttttgtc tctgtaaaga tttaagaaat 2557921 cataagattg aagaatcatg tagctgaatt ccgtgtacga gatgccggat tcaattcttg 2557981 agctgaccgt atcttttgcc agcatgtaat tgatgccgaa atttttacca acgtcacgaa 2558041 ggaaatcgat cacattcatt ttgccgatcc agtcaaagtt gttcgcgatg acagctgggt 2558101 tttctgctgc ttcaaaatct agaaatctgg acagctggtt tttgattttt tgggaccatt 2558161 cggatacgat gtcagcagtg tttaatgtac gctctgcttt ttttccgctt ggatcaccga 2558221 tgaggcccgt cgcgccgccc acaagcgcaa tcggatgatg ccctgcaagc tgaaaacggc 2558281 gaagtgttaa aataggcagc aggtgtccga tatgcaagct gtctgctgta gggtcaaagc 2558341 ctgagtacaa gcggattttt tcttcattca gctgtttatt taacccttct tcatctgtca 2558401 tttgctgaat caatccgcgg aaggataagt cttcaagtaa gttagtcata agataaagct 2558461 ccttttttaa ttaaaataaa aaacgcccct tcgtttacac gaagggacga ttgattatcg 2558521 cggtaccacc ctactaataa gagaatgcaa acattcgtct tatcactttg cctgataacg 2558581 gatcaggtcc gttctttcac tactgaaagc ctggccggct ttgtttgcaa aagcggttca 2558641 tgagtgtatt cgatatatcc gtctgtgctg attttcaccg gccatcagct ctctggaacg 2558701 taaggatatt ctacttgtct caatctttac cttttcatat gaagctatat catttttaac 2558761 ataaataaaa tcctgtgtca acgccgcctt ttaatcctcc attgttgaca gatctccagc 2558821 cggcagatta agctcccatg ccttcagcac gcgcctcatg atctttccgc ttctggtttt 2558881 cggaagctta tctttaaatt cgatctcacg cggagccgca tgggctgcaa gaccctgctt 2558941 tacaaatagg cggatctctt ctttcagttt atcagacggc tcaaatcctt ccctgagtgc 2559001 aataaaggct ttaatgattt ctccacgcac cgggtcaggc tttccgataa cgcctgcttc 2559061 tgcaatagcc ggatgttcga caagcttgct ttccacttca aatgggccga cgcgctcacc 2559121 ggaggtcatg atgacgtcat caactctgcc ttggaaccaa aagtatccct cttcatccat 2559181 gtaagcagaa tccccagaca cataccagcc gcccggcatg aaatacgatt catacttttc 2559241 agggttattc caaatggtat gcatcatgga aggccagccc tttttgatgg cgagattgcc 2559301 cattcggtac ggcggtagct cgttgccttg attgtcaacg atcgctgcct ccactcctgg 2559361 aatcggctta cccattgaac ccggtttaat atccatgcaa ggatagttgc agatgagctg 2559421 actgcccgtt tcggtcatcc accaggtatc atggattcgt ttgttaaaaa ctttatgtcc 2559481 ccatctgatg acttccggat ttagcggctc accgacactg agcacatgcc ggagtgaagt 2559541 tagatcatat ttcgcagcca tttcatctcc cgctcccatc agcatccgaa aagctgtcgg 2559601 cgcgctgtac cagacattga cgccaagctg ttcaatcgtt ccataccagc tttccgggct 2559661 gaaacgtccg ccgacgatga catttgtcgc tccgttcagc cacggtgcaa aaatgccgta 2559721 taccgtacct gtcacccagc ctggatcagc cgtgcaccaa taaatgtctt cttcctttaa 2559781 atcaaggacc cactttcctg tttgatattg ctgaatcatc gcttcatgga catgcaacac 2559841 gccctttggc gtaccagtgg aacctgatgt atagtgaagc agaaagccgt cttttttatc 2559901 catccattcg atatccaatc ttgtgctttc ctgtttcgct gcttcatcat aattgatgat 2559961 attcgtgccg ctctcagcct ctcccccgac tacgaagaca tgctgcaagt gaggcagttt 2560021 gtctaccggt attctctcca gcagctcagg cgttgtgaca acaacctttg cctcactgtt 2560081 ttcaagccgg tctttcaccg ctccctccat aaatgcttcg aacagcggcc cggcgatggc 2560141 gccaattttg attgcgccaa gcataataaa ataaagctcg ggtgatctcg gcataaaaat 2560201 aaaaacgcgg tccccttttt ccacatttcc ataccgtctc agcacattcc cggctctgtt 2560261 tgattcttcc ttcatttctt taaatgtgta tttttcatcc ctttttgcgt ctttataata 2560321 aagcgctact ttgttttttc gaaacgattc ggcatggcgg tcaatcgctt catacgccgc 2560381 attcagtttc cctgtctcat gccaagagaa atgtttctct gcctcggccc aatcaaaatg 2560441 ccggtacgtt tcttcatagt tttttaagtt atgatccccc tctattgctg gtaacgcttt 2560501 caagttcatg cccaaacatc cccctttgct gaagttgtca caattattat agtatatatt 2560561 catattcttc tcaattttta aaatataaac catgttgaaa acgctttata atttggtatt 2560621 cttaaagaag gcatgtattt ttgataagaa ttgatgggac ggtgaattag tggaacatca 2560681 taaaacatac cattcagcaa acatcaaaac agcaaccggc tctttactga tagaagggcc 2560741 tgtctctcca gaggatttgg caggttatga gtttcataaa gatttaaccg catttcgccc 2560801 gcctcgcgag cagcatgaag cgctagtcga cattgcaggc cttcccgaag ggcgcattat 2560861 tattgccaga gacggccgaa ccattgtcgg ctatgtcacg tatttatatc ctgacccgct 2560921 cgaaagatgg tctgaaggaa atatggagga tttgattgag ctcggagcca tcgaagtagc 2560981 gccggactat cggggatgcg ctgtcggaaa gacgctcctg accgtcagca tgatggatga 2561041 acaaatggaa aactacattg tgatgacgac agaatattac tggcattggg atttaaaagg 2561101 gatgaaaaaa gatgtgtggg aatacagaaa gatcatggaa aagatgatga atgcaggcgg 2561161 attggtctgg tttgcaacgg atgagccgga gatcagctcc caccctgcaa actgtctgat 2561221 ggcccgcatt ggaaaaaacg tcagccaaga atcaattgag caatttgaca ggctccgttt 2561281 ttatcatcgt tatatgtatt aactgacact gacaaagggg aaaaaataat gattgttgag 2561341 caaatcatga aaagagatgt cattacatta acgaagacgg atacgcttga aacagcaata 2561401 tgcaaactga aggaattcca tatcaggcat ctgcctgttg tagatgaaga acgacacgtg 2561461 atcggcatga ttacagacag ggacatgaaa caggccagcc cgagtatttt tgaagaaaac 2561521 aaacgaagcc tatttctcac acgaagcgta gattcaatta tgaaaaagga tgttgtctgc 2561581 gcccacccgt tagattttgt cgaagaaata tcagccgtgt tctacgagca tggcatcggc 2561641 tgcctaccag tggtacacca tcaaaaatta ataggcattt taacaaaaac cgatttgctg 2561701 cggacgtttg tcaaattgac aggcgctgac cagccgggct cgcaaattga gataaaagta 2561761 aacgacatca ccaaaagcct cgctgagatc agcagtcttt gccaagacct tcaagtgaaa 2561821 atattaagcg tgcttgttta tccgcatgac gatcccggtg taaaagtgct tgtcttccgt 2561881 gtaaaaacga tgaatccgct gccgtttttg caggcattac aaagaaatgg acaccacgtc 2561941 gtatggccgt cagagcaaag ggatctgcta tgagagacag tgtatttatc tattctccat 2562001 cctaccaaac ctatatgttt catcaggagc atccctttaa tcagcagcgg gttctgttaa 2562061 catatgattt gcttaagacg atcaatgcct ttgatgatgg agacattgtc acccccagac 2562121 tcgcttcaga agaggagctt tcccttgtcc acacggacga ttacattcag gccgtaaagc 2562181 ttgcgggcgc cggaaagctc cccgctgaag aaggagaaag ctacgggctc ggcactgaag 2562241 acacacccgt ctttgccggc atgcacgaag cggcatcact cttggtcggc ggcactttaa 2562301 cggccgcaga ctgggtcatg tcaggacaag ccctgcatgc ggcaaacctt ggcggagggc 2562361 ttcatcacgg ctttcgcggg agagcatcag gattctgcat atacaacgac agcgctgtgg 2562421 ctattcaata tatccagaaa aaatatagcg ccagagtgct ttatattgat acggacgccc 2562481 accacgggga cggtgtgcaa tttacatttt acgataatcc tgacgtatgc acgctgtcca 2562541 ttcatgaaac aggaaggtat ttattccctg gaaccggtca gatccaagaa aaaggaagcg 2562601 gaaaaggata tggctattcc tttaatattc cgcttgacgc ttttacagag gatgattctt 2562661 ttcttgaggc ttaccggaca gcagcttcag aagtcgccgc gtatttcgag cccgatgtca 2562721 ttatcagcca aaacggcgcc gatgcccatt actacgaccc gctgacgcat ttatcagcaa 2562781 caatcaatat atacgaagaa atcccccgtc ttgcacacac tttggctcat caatattgcg 2562841 gagggaaatg gattgcagtc ggaggcggcg gatatgatat ttggcgtgtc gtgccccgcg 2562901 cctgggccag aatatggctt gaaatgaagg gaattgaccc gggtcacgag atcccgccgg 2562961 aatggattgt taaatggcaa aaacaatgcc ccgtggccct tccgtcgagc tggagcgatc 2563021 cggctgattt atatcctccg attccccgca agcctgaaat tacagaaaaa aatgcccaaa 2563081 ctgtcagcaa agcattatat gcgatacgtt ctgaacagca aagaacaaag taaaaaacga 2563141 cctttacgaa gaggtcgttt ttgatttttt aatcactatt tccacacgcc gattttcctt 2563201 catgtgttca tttgtcttgt tatcctttac tggctttgta tccgcataac cgacagcaat 2563261 aaagcgcttg gagggaagct tctctttaga cgtgaagtat tgaatcactc cacttgcccg 2563321 tgctgctgat agctcccagt tcgacgggta tcggtatgtc gaaatgtttc ggctgtctgt 2563381 atgtccctca acctgaatgt catttggaat tgtttgaaga agaacggcaa tttggtgaag 2563441 aagtgtttcg gcatttttca gcacctttgc ctcacctgta tcaaacagca cagcctcctg 2563501 aagaacgagc acgacaccgc gttcatcccg tttggctgtc atttgggcct tcaaatgatt 2563561 gtcttttata tatgtattta ctttcttgag aagctgatcc tgctgatcct cttgcttctt 2563621 cgtatcagat ggggatgtat tctttttttc tatggatgtt tggtccggct gaagcccgtt 2563681 gccttccttc tggatcgagt ccactgccgc tttgaatttt tgcagatcga tttgggacat 2563741 cgaaaagagt aaaataaaga acacaaggat caaggtgatc agatctgtaa aggttaccat 2563801 ccagctggat gaagattgac tgttttttcc gcttccattc cttctttcaa aacgttctct 2563861 tctaagcttc atgtacagat cccttttttg tttttacttg ttttggctgc ttctgccatt 2563921 cttcccgtga gctgaaaacg accagctggc tttcaaggtt gcgcgggttt tttccggatt 2563981 gaacaccgat aatcccttcc accattacct gcttgatgaa aatttcactt tctgttttct 2564041 cttcaagctt agccgcgatc gggttgaaga ccatatttgc cagtaatgaa ccatataaag 2564101 tcgtcagaag cgcaatggcc atgtttggtc cgagcatatg cgggtcgttt aagtttttga 2564161 gcatcagcac aagcccgacg agtgttccga tcattcccca tgccggagcg aattctcccg 2564221 ctttttcaaa aactcgccgc ccttttcggt gccgttcctc cattgctgcg atttctgaat 2564281 ccatgacgag ccgaatcgtt tcttcatccc agccgtcaat cgctaaaagc agcccttttt 2564341 tcaagaatgg atctttgatt tcccgagcct gatcatccaa tgataaaagc ccgtgttttc 2564401 gcgcgtgatc ggaaagggaa acaaaggttt tcacaagatc tttcacattg tcttcctggc 2564461 ggatgaatgc ctgctttaac acagagggcg cttttttcag ctcacttggc ggaaaactga 2564521 taaaaacagc ggcgcaaagt ccccctgtta cgatgaagaa agaggtcaga tcaagaaaag 2564581 agcggaaacc gcttactccc gatcctgaaa taatcccgat aacaataata atcgttccta 2564641 acacaaatcc aacaggtgta agataatcaa aacgtttcat catttctccc catgaaaaaa 2564701 gcaagaattc accataaagg tgaagcttgc tctttgtttt tcttatgact tggttgactt 2564761 tctaagctct atacggtgcg gcagttcgac gatatgctct tcaaccggct ctttattcat 2564821 gagcttcgtc agcagtctca tcgcaacggc gccgatatca tatgtcggct gaacaactgt 2564881 tgaaagctga ggacgaacca tgaggcttaa tcttgtatta tcaaaaccga taatgtcgag 2564941 atcctccgga atggataagc cctgatcctg agcggcatgg ataatgccga gtgccatttc 2565001 atcagttgca gaaagaatgg ctgtcggttt tttatccagg ctcatcagat gctgcagtgc 2565061 ttcgagtccg gaatcatatg tgtaatcccc ttcagctaca aattgttcat taaacggaag 2565121 gttcgcttct tcaagcgcac gtttgtagcc ttggagtttt ttcgaacggt tgatcggttc 2565181 tgccattggt ccggaaacga acgcgatgtc tgtatgtcct ttatcaacca aaagcttcac 2565241 ggcatcataa atcgcctgtt cgtaatcgat agcgactgac ggtgtttcct cctgctcttc 2565301 tacagaagcg gcaagtacaa tcggcactgg agaacgctta aattccgcca catgctcgtc 2565361 cgtaatgttt ccgcccataa acacgatgcc gtccacttgt ttgccgagca ttgtgtttaa 2565421 caagtgcagc tctttctcca tgttttggtc agagttgctc aaaataatat tgtatttata 2565481 cattgtcgcg atatcttcaa ttccgcgcgc aagctctgaa tagaaaatgc ttgagatatc 2565541 gggaatgatg acacctacag ttgttgtttt tttacttgcc agccctcttg ccaccgcgtt 2565601 tggacggtaa ccgagacgtt caatggcttc caagactttt ttcctcgttg tcggttttac 2565661 attcgggttg ccgttcacga cacgggaaac ggttgccatg cttacattag cttctctcgc 2565721 tacatcgtag atcgtaatat tgctcatcct aaaaccactc cttttactgg atacacttat 2565781 ccttatctat agcataaaca ctttatgtag agaaatgtca taatgtccga atttatgtcg 2565841 tttatgattt gtaagcgtaa gtcagtagtg tacattattt ttcattattc atcaaattta 2565901 attacttctc atgaaattat acacgttttt atagatgatg aaaacgtata cttggttttt 2565961 ataactaaat aaacgagaaa gcataaaaaa aggccgcagg cgcggccttt tggattgttc 2566021 aattaagcgt tgactttcac cattggcttc agttcattca gccatttttc gaattcagga 2566081 atcgccattt gctgagcaga gtcagaaagt gcgactgacg gatcagggtg aacctcagcc 2566141 attacgccat cagcaccgat cgctaaagcg gctttagctg tcggaagcaa gaggtcacgg 2566201 cggcctgttg aatgcgtaac atcaacaaag actggcaaat gcgtttcttg tttcaaaatc 2566261 ggcacagctg aaatatccag cgtgtttctc gttgctgttt catatgttct gattccgcgc 2566321 tcacaaagga taatttggtc atttccttgt gacatgatgt attcagcagc attgatgaat 2566381 tcagagatcg ttgcagcaag accgcgcttc agaagcactg gctttttcac ggcgccggcc 2566441 gctttcagca attcgaagtt ttgcatgttg cgcgctccga tttgaatgac atcaatgtag 2566501 tccagcgctt cttcgatatg agccggagtt acgatttcac tgataaccgc cagatcaaat 2566561 tcatccgcta cacgttttaa aatttgaagg ccttcaacac caagcccttg gaaatcgtat 2566621 gggctcgtac gaggcttaaa ggctccaccg cgcaaaattt taatcccttg ttttttcgca 2566681 gctgcagcga cttcagctac ctgctcatag ctctctaccg cacatgggcc gacaatgaat 2566741 ctttgctggc cgtctccgat tttttcgcct ttgatatcaa caattgtatc ttcaggtttt 2566801 ttcttgcggg agacaagcag cgctttgctg tgatcttctt cctgaagctc taaaccggct 2566861 ttgaatatct ctttaaaaat gtgctggatg gttgaatttt cgaacggccc gtcattgttt 2566921 tcaatgatat tgtttaacat tgtgcgttct ctgacagggt caaatcggtt gacaccctgt 2566981 gcttccttcg ctttaccgat ctcttttaca acattgccgc gttcgttgat taattttaaa 2567041 atttgtaggt ttaattcgtc tgctttctgc cttaaaagct ctaactctgt gttgctcatt 2567101 tttttcatcc tttccctgca cattcatttt ttattttgta gttatcatgc atcttactat 2567161 aagtaattcc aaatggaaat actgaaatac aaaaaatttt ataaaaactc tactttatta 2567221 cccaaacgct tttaagtgat aaagtaatct atgaagctat cctacatgat gtgagggcaa 2567281 tgttcaaggg ttttttacaa aaaaaagcgc cagatgatat ctggacgctt ttttctatga 2567341 caaatgctgc tcaatagcgg cttctgtaat ttgtgaatgt gaggtatgcc atttcacttc 2567401 accgttctgg atgatgaata tctgagggct ttcatgcttg accccatatg tttctgcaat 2567461 gaaattggac agcggccggg cttcttgtac ttgaagatag taagccggca catcctcatg 2567521 ctgatttgca aaggcatcaa actcatgaaa tgctgcctgg ctgatcgggc atgtggtgct 2567581 gtgtttcaag aagacgaaaa cgccttcctg ttctgcaatc cgtttaaatt cttcctcaga 2567641 ttgaataagc tgtttagcca tgactcaagc tcttccttcc ctgctcagcg attcaactgc 2567701 tcagcctgtt tttgtgcatc tttcagttcg tcttttacat cttctttcgt ctggaggact 2567761 tgatcttttg tttcatcagc tgcctgcatc gcttcttccc tcatatcttg cattgcagtc 2567821 gatgaatccg ttttgtcaga tttggaacgg tctctcaaat cctttacctt gttcatgatc 2567881 tgtccagact gatccgctac aagctgtgtg atgttggaag ttttgtcttt tgcgatgctg 2567941 acatattgcg tgcctttttc cttcgcatct gccgtcattt tatcagtttt gtcccgtaag 2568001 gcaacagcct ggctgccgag atcgtcgcga agttctttgc ctgatttagg cgctagaaaa 2568061 agagctgtag tggcaccgat gattcccccg attaaagttc cgattaaaaa atctttacta 2568121 ttaattccat ctttgctcat cattattcct cctcttagta tttttttctc ttacagggct 2568181 gattttttct tttgcttcca tttctcccaa atttccattg ctgcttgact ccaagtgaca 2568241 acttgattga tcttatcttg attctctcta actgatgccg atacagaccc tgccgcttgt 2568301 ttcatggatg tattgaactg ctgtacagaa gctcccactc cttgaacagc atgaacgacc 2568361 gtgttcagct tttctgattt ttcctgaata tcttcagcca ggcggttggt cttatgtaaa 2568421 agctcggctg tttcagttgt gatgcccttc atttgtccct ccagcccttc aagagtggat 2568481 gcgacgtttt ttagtgtcag ctgcagtgac ttcaatgttt tagacaagta gatcactaat 2568541 acgagaaatg caactgcgat gagtgcaacg ctcaaataaa gaataataat catctcaaac 2568601 ctccttgctg caggatatac tgctgtttac ccgttttctt caatcataaa catgtgtact 2568661 gggctgtata catactattc tccgttatgt aagaaaatcc tttaataagc tttcccatca 2568721 gataaataaa aagcagtgag atcactgctt tttattatgc catgacgttt tcgtaggctc 2568781 tcatatattt ttggatatct cctgctccca tgaagatgag aacggcttta tcatgagctt 2568841 ttaaaacaga tgtgtcatct tcttcaatca gcttggcatt atgaattttt ccctggagat 2568901 caccgatcgt cagctttccg gcattctcac gggctgagcc gaaaatatcg cataaataca 2568961 cacagtcggc gccgctcagg ctttctgcaa attcgtcaag gaactgctgc gtccgggtaa 2569021 atgtatgagg ctggaatacc gcgacaattt cccgatcagg atacttctgt cttgccgcct 2569081 cgattgtcac ttttatttct gtcggatgat gggcatagtc atcaatcagc acttgatccc 2569141 caagctgctt ctcattgaat ctgcgtttga cgcccccaaa ggatttgaga gcatgcttaa 2569201 tgatgctgga atcaatttct tcataatggc ataacgcaat gaccgccaat gagtttaata 2569261 cattgtggtg gccgtacgca ggaatataaa acgtatcata gaacgtattg cggacaaaga 2569321 catcaaaagt tgtcccttcc gtgcttttta cgatgtttct ggcttgaaaa tcattttctt 2569381 cccccgtgcc ataatacaca accgggacgt tcgcatggat tttcggcaga tgctcatcgt 2569441 ctccgcaggc aataatgcct ttgttgactt gaagagccat ctcttggaaa gcgtcaaata 2569501 catcgtcaat gcttgagaag taatcagggt gatcaaaatc aatattcgtc ataatcgcat 2569561 aatctggctg atagcttaag aaatggcggc ggtattcgca cgcttcaaac acaaagtatt 2569621 cgctgttttc atttccctgg cctgttccgt ctccgattaa gaaagacgtc ggttttgcgt 2569681 tttggatcac gtgagccagc agacccgtag tcgacgtttt gccgtgtgcg cccgtaacgg 2569741 caacactcgt gaattttttc atgtagtcgc ctaaaaactt atgataacgt atcaccggaa 2569801 ttccctcaga catcgctttt tctatttcag gatgcgtgtc tgggaatgcg tttccggcga 2569861 tgactgtcat gccgggttta atattttccg cgctaaaagg aagaatcgta atatttcttt 2569921 tttcaagcgc tgtttgcgta aaaataaatt tttcgatatc cgatccttgg acagtatatc 2569981 cattatcatg aagtatttgg gcaagcggac tcataccggt cccttttatt ccaacaaaat 2570041 gataaacagt cataattgta cctccaacaa acgtctatct gttccccagt atatgacgct 2570101 catttcaatt tgcgaccgcg gcggctgaaa agcctccctt agcggcgtat tttatatgtt 2570161 ttgttatgtt tagtatcagg ttatttcttt ccgattaaac ccagatatca agatttgtct 2570221 atgcacagct gctgtaaagc ggcatagctg ttaaatgctc taaacactat cataccatgt 2570281 ttggtgtgaa aatgaaccca tattattcgt ttattaaatc acttgctgtg atcagcacct 2570341 ctcgaggctt gcttcctttt gcctcagaga tcatgccttc cgcttccatc atgtcgatca 2570401 gccttgccgc acgattgtaa ccgattctga atcttctttg caggcttgaa gtgctcgcac 2570461 tgttttgctc tacaacaaac tcacacgctt cgtaaaacag ttcgtcctct tctttcaggg 2570521 cagatccttg tcttacgagc tcttcttgtt caaataaata ggtcggcggc atttggcttc 2570581 tgacgtggga aacgacgcgg tcgatttccc ggtctgacac aaagttacct tgcagacgaa 2570641 ccggttttcc cgagccgttt tccaaaaaga gcatatcccc ttttccgaga agcttttctg 2570701 caccggctat atcaataatt gttcgggaat caacctggct tgagacagaa aaggcgattc 2570761 tcgttgggat attcgcctta atcagacctg taatgacatc gactgacgga cgctgagttg 2570821 cgacgagaag atggataccg cacgctctgg ctttttgggc gatccgcgca atgctttctt 2570881 ccacatcgtt tggagccacc atcatcaaat ctgcaagctc atcaataatg acaactaaat 2570941 acggcagctt ttcacccatt tggtgttcag cggttaattg attaaagcgg tcaatgtcgc 2571001 ggacacctga atgggcaaaa agctcatagc ggcgctccat ttcctcaacg acccatttca 2571061 aagcagccgt agccgcttta gcatcagtaa tgaccgggct gacgaggtga ggaattttat 2571121 tgtaaggggc cagctctacc attttcggat caatcagcag cacctttacc tcactcgggt 2571181 cagctttata aagcaggctt actaatattg tattgatgca tacgcttttt ccggagcctg 2571241 tagcgccggc aatcaagcca tgcggcattt tcttcaagtc gataacaaca ggatttcccg 2571301 aaatatctaa tcccagcgca gctgtgagcg gtgacttgct tgtcctgaaa gctgagctgc 2571361 gaatcatttg gcgcaaatca accaccttgc tcgtgcggtt cggcacttca attccgatcg 2571421 tgtttttccc cggaatcggc gcttcaatcc gaatatcttt agctgagaga ctgagtttaa 2571481 tatcatcgga caagttggtg attttattca cctttacacc cggttcagga tgcacttcaa 2571541 atctcgtgac agacggaccc tgggttacat ggaccacatt ggcgcggaca ttgaaatttt 2571601 tcaaggtcaa atcaagaagc tgacgctgtt cttcgatcca cgcagtatca tcttgaacct 2571661 gcgctggcgg gacatcaagc agtgcaacat tcggaaatac atagctgccg cggcgctcct 2571721 ctgctttttg ctgtttatgc gtatctcttt tcagcatcat cacattaaaa ggaacggatg 2571781 gccctttttg agaagatgcg ctttgttcag tccttttctc ctgtacacca ggcctttttt 2571841 tcggctcttc tgaagcttcg cgaggtttgt ctgcgcgaat ttcctgccgg ttttcaagag 2571901 ttgcagtaga cgatttggaa ccctgctcca tgtgttcagt tttctcaagc tctgtatggc 2571961 tgtctggctg aacatctatc ttcgtttcct gagcctctcc cagggtgtca taatgattat 2572021 ttattatgct ttctgatggc tcttctgatt cttttgccac agtttctgct tgagccagag 2572081 cctctgatga atactcatga tcagtaaata aaggctcttc ctgacgaatg tccatttgtt 2572141 cttcttgaac gaacggggac tcagcacctt ctgccgcgtt ttcatgatga ttgtatactg 2572201 ggctgtctga cggctctttt gctttttcat cctcagatac tgcctctgtc tgagattcag 2572261 gagctgtttg ctcttcatca agttcagcgg agaaaacagg ctcttcaaat ttctctggct 2572321 gctgctccct ttgttcttcc tcagccgttg caggctcttc gcggcctact tcactgtctg 2572381 aaagcccttc agccgccgta tctgtgagca tctcaggcgg tgtttgctct tcggcttgtt 2572441 cagctgggaa gaaaggctcc tctttttccg gctgttgaac gcctgactca aatggcactt 2572501 tgttacctga cggctcggct ggccgtttcg ccagcgcctc atcatgctcc gtatcctttc 2572561 tgtttaaaac gccagaaggc tgtttttcaa attgggtatc cgggaagaaa ggactttcta 2572621 ttttggaatg cgcctgtgtg tctgaagcag gatagccgcg ttcacgttcg atctcttctg 2572681 acagcagtgt taccttctct tttaccgatt tatccggttc gttcaatgtt tcagaaggct 2572741 ttttcggcac atccttttta acagatggtt tttgattgaa tccatagaca ggcgaaggga 2572801 tatttgtcgg tttaaacggt ttcttcgccg gctctgctgc ttgatatgta tgctgctctt 2572861 cttcatttct gggacgctct ctgtaaggtg cagcacttgg acgaggcgcg gatttcggtt 2572921 cgtccgatgg tgtgcggcgc cttctcaggt catgattttt gtatccgtca ggcacgactg 2572981 gaaaacggaa tttgcctttt ggatattcat aatatatttt aggatcttcc aatcttttta 2573041 attgtccttc aggatgatgt acttcttgtt gctgcggaat ttgagcgggt tttgtctccc 2573101 gttcagcatc ctcttcgctt tcgcctaaaa acaaatcaaa aaatttatga agccaactca 2573161 taatttatct ctaactccct tatagttttc tgggacggtt tttagtatac cactgctggt 2573221 cggcccagaa aagattaagc tatcagcaga aacaaagccg ctaaacaagg gcttagcggc 2573281 ttttcacatg attcgttttt tttggcggat ttatgggagt ctaaaactga aatgcgtctc 2573341 ccgcctcata gtctccttct aacacaagga ttcctttttc agcaggggca tccggcaaat 2573401 caagctcttt cgctgagcag atcatcccgc ttgacggaac gccacgaagc tctgcatcct 2573461 taatgacaag tccgctaggc atcacagcac cgactttggc aacgacaact ttttggcctt 2573521 ggtcaacgtt aggcgcgccg cagacgatct gaagcgtttc ttctcctacg ttgactttac 2573581 atacgcttaa tttatccgca ttcggatgtt tttcttttga ttctacataa cccacaacaa 2573641 acttcggaga taaatcaacg actaatgttt cttcaacgcc gtttctgttt aaaatctcat 2573701 tcacatcttg cacgaatgtt tctgagagcg caacagggcc gttttcatca atggtcaagt 2573761 aagaagacgc attgaaaatg ttgaagcccg ttgtttcttt tgtttcgtta ttgaaaattt 2573821 tgacgacgtc gccgtgtttt tcatagccta attgttcgcg tgtcacatct tgaagagaga 2573881 tcaggagcgt gtctcccaca ccttctttat tataaaaagc gttcataagt aaaaatcctt 2573941 tctaatcctt tttcggacgg cttttcgcca ggataaacac cggttccagc tttccttcat 2574001 tgtacaaaaa tgatagggcg gtaatcggga cggtgccgcc tgcaaagaag ctcatcgaca 2574061 tttgtcctag aatatcatac cccgattcat tccggatgtc agcaagaatc aaaacgtcct 2574121 gatgaggaac agagatcgcc agctcacctt ctgcatgctg cttatactca tttaagatcg 2574181 cttcgttcaa aatccggctt gcgtcgtatc cgtcgtttgc cctgaagaaa taaaagtaat 2574241 tgccggcaac cgtatcctct ttgacaaccg tcggcaggga acggagatta aatgcggccg 2574301 tctctctgat ccgctctttt gtccagtttt ctttctcaag catgcgctgg tcaattaaac 2574361 ggtaggtttt cccgagatct agcgcgtaat aaattcttgt ctctgcggta tgatcgtcat 2574421 aaatgagcgg gatatcttcg ctggacttgt ccgggaagga agtcgagcgg atgaccggat 2574481 aaatgcgagt ttctttcccg gtcatttcct gagccttccc ttccattgcc gtcatcgctt 2574541 cggagacata gtacacgatc tcatcaatgg cttcgtcttt tttcagttcc cattttgcaa 2574601 taatcggcgg caaatcgagt gtaatccctt ttttagtcgt ttgatcctca acacggaggg 2574661 tgtctttttc tctgtcaaac agaaaggagc gattctcgtg ctgaaggcgc tgcttcagta 2574721 tatctgacag cttccttgag gtcattttca aaccgatgtc ctcctttacg ctttagcgag 2574781 agagtctgtt aaaaactgtt caatttcttc ttttgttttg cggtctttgc tcacaaaacg 2574841 atttacttct tttccttcat taaacaccac aaagcttggg attccgtaaa tttcccactc 2574901 tgcacatgta tcaatgaatt tgtcacggtc tacgtagtag taggtgaatt cagggaaatt 2574961 cgcttccagt tcaggcagga aaggctctac aaaacggcaa tccgggcacc aatcggccga 2575021 aaacataaat acagaccaat catcctttac cgctttttcc agctcttgag ttgattcaat 2575081 ttttttcatt tcatatccct ccagttgttt atgttcttac atgtttttta tcgatactcg 2575141 tccatttgga tcataccaaa ctgcttgagg caaaaccact tatatgcaac gaatgaatat 2575201 gtaagattgg ctttcccatt atcattatca tattttattt gcattatcaa gctcgtttcg 2575261 tttaacatcg tgtacatgag ggtgaaattt acagatggat atacataagg agggattttt 2575321 attatggagt ttatcgtcta tttagcagga gaaatccaca gcaattggcg cgaggaaatt 2575381 aaagaaaaaa caaaatcact gaagctcccg attacgtttg ttggcccgat ggagaatcat 2575441 gaccgctcag acaatattgg tgaagaaatt atgggcgtac agccaaatgc cgttttaaag 2575501 gatgacaaag cctctgacat caacaacttc agaaccgccg tcctgatgaa taaagcagac 2575561 tttgtgatcg ccctgtttgg cgaaaagtac aaacagtgga acacggcaat ggatgcatca 2575621 tatgcgatcg caaaaggaaa acccctgatt atcatccggc cggaatcgct ccaccatcct 2575681 ttaaaagagc tttccaataa agcgaatatt acggttgaaa ccgttaacca agccattaag 2575741 gccctttcct atctatttga aacagaataa gaaaaaagct tgtcgatccg ggcttactgc 2575801 tcgttcaaca agcttttatg aaacctacat attttcttta atcgcatcca ctgtctgctt 2575861 atcgcaggct gttacaagtt tgatgagcat ttctttagca gcagcataat catcaatatg 2575921 aatgatagta gcgtttgtat gaatatagcg ggaacatatt ccgataaccg ctgacggcac 2575981 accgctgttc gaaatatgaa ccttgcctgc gtctgttccc ccgccggata caaaatattg 2576041 atatggaata tcatgcgttt cagccatatc aagaacgaat tccctcattc cgcgatgcat 2576101 gactgtcgtt ctgtcaagaa tgcgcagcaa aaagcctttt ccaagctggc cgaattcatt 2576161 tttgtctccg ctcatatcgt ttgccgggct ggcgtcaagg gcgaaaaaca agtccggttt 2576221 aatcatatga gaagccgtct gcgcgcccct tagccctact tcttcctgaa ccgttgcacc 2576281 cgcatagagt gtattcggaa gctctttacc gtgtaattcc ttcagaagtt caatgcttaa 2576341 gccgcatcca tatctgttat cccatgcttt tgataaaatt ttcttttcat tcgccatcgt 2576401 cgtaaacgga caaacaggca cgatctgctg tcccggtcta atgccgattt tgatggcgtc 2576461 ttccttatca tccgctccaa tgtcgatcat catgtttttg atatccatcg gtcggtttcg 2576521 ctgcgcatct gtcaataaat gcggcggtat gcttgaaatc acacccggaa ccggcccgtt 2576581 atctgtttga atttcaaccc gctgcgcaag caaaacttgg ctccaccagc ctccgagcgt 2576641 ctggaatctg agcagcccgt tgtctgtaat ggatgtcacc atgaagccga cttcgtccat 2576701 gtgcccggct accataattc tcggtgcgtc ctctgcgcct cgtctgactc cgaaaacact 2576761 tcccagtctg tcctgaacga tgtcatctgc atatttggct agctcctgct tcataaaagc 2576821 acgaacctga tgctcattgc ccggcgcgcc gggaagctgc gtcagtgttt ggaaaagcgc 2576881 tttcgtttct tgattcatgt tttcccctca tttctatgta gtccttttat tttattagaa 2576941 acaatgaagt tttccaagca ctctgaccca atctgctcga tcagccgcgt attgcttaac 2577001 aggatttggc tgtttctgta taatgaaaag tacgatcaac caggaggtgc tttattttga 2577061 aattgcgtca tcttctttta ggagcaggac ttggaatttg tacggctgtc gttgtgagac 2577121 aatatgtgat gaagccttat atttcttcag aaaaagcgct tcgaattgta aaatctgctt 2577181 ttaagcagcg gggcccgatt gacggatcat ggatttacac ccagccggag ccctacaata 2577241 ttaacggaga aacggtacag gtatacaaaa ccggcattac acgatcagct ttcggagaat 2577301 tagaacagta tgaagtcatg gtggatgcga aaacgggaga aattgttgat gtcattgata 2577361 caatcgcctc ttaacaccgg acaagcaaaa aatagaagcc gctgcctatg cagcggctct 2577421 tttttattat atcgcgcgaa tcggtttgta taccggatac cacatcgcat cctgcactgc 2577481 ctgtataatg tcttcaggct cttccgtagc gacgccttcc ttcattgcgg tttttgcaac 2577541 ttcaacagca acggttgccg aaacagtgcg caaatcttca acttttggaa gcatcggcgc 2577601 cccaggcacc ccgacattga ccatacctgc gattgcccgg gcacatgctt caaacatgcc 2577661 gtcggtaatt aattttgatt ttgtaacaat cgttccaaga ccgagaccag ggaagacaag 2577721 cgcgttgttt gcctgcccga tatgatacgt aactccgtta tattcaactg gcgggaacgg 2577781 gcttcctgtc gtgatcagcg cacggccttc tgtccattcg attaaatcct ccggctttgc 2577841 ttcagaaaga gttgtcggat ttgacattgg caaaatcgcc ggccgtttca catgtgacgc 2577901 catttctttt acaatttctt cagtgaaagc gccggaaacc gtagatgtgc cgatcaggat 2577961 cgtcggtttc gcctgccgaa ccacttcaag aagatcaatg cctccgccgt ctccgttccg 2578021 ctgataatcc ttcacttcat cagccgaacg ggcatacggc ttttggaaat caagaagctg 2578081 atccatatca tctgttaaca gcccgttcct gtctatgcac cagaagcgct tgtatgattc 2578141 ttcttcactc agtccctcgc gcaccaatgc ttcccgcagc tgttcggcaa ttccgattcc 2578201 tgccgttccc gctccgaata taacaactct gtgatctctc agcggaactt tagacgcttt 2578261 tgcacaggat aagactgcgg ccaaagaaac agcgccagtt ccttggatat catcattgaa 2578321 ggtacacact ttatctttat agcgtttcaa aatgcttcgc gcgtttttcg ccccgaaatc 2578381 ctcccaatgc agcaatgcat tcggaaatgt ttctctcgcc agcgcaacgt agtcgtcaat 2578441 aaattggtca taacgttccc cgcgcactct ggaatgctgg ttgccgacat aaagcgggtc 2578501 gttcaagagg ctctcctgat ttgtccccgc atctaaaaca acagccagca ctctgctcgg 2578561 atcaatgccc gcagccgctg tataaaccgc cagcttgcca atagaaattg cgattcctcc 2578621 gacgccccag tcaccgattc ctaaaattcc ttccgcatca gttgcaacaa ttaaatcgat 2578681 cgtatcgctt tgatctttat actgtttaaa agcttctttc ataccgtccg ggtcatcgat 2578741 tgacagatag agccctcgtg gttttctgta ttcatggctg tatctctgaa ttgccgttcc 2578801 gactgtcggt gtgtagacaa tcgggagcat ttcccctaaa tggtcattta acaggcggta 2578861 aaacagcgtt tcattccgat cgtgcagcgc cgttaaatag acatttttgc tcaaatcgtc 2578921 aggctgtgcg gaatattgtt catacgctct tttcgcctga tcatcaattg ttaatacctt 2578981 gggcggcaga aagcctttta aaccaagttc ttttctttct tcctcagtaa aagcaacacc 2579041 tttgttcaaa aaaggaacag agagcacttc aaggcctctt aatgttgttt gaatgtctcc 2579101 ttcgtttgtt actctgaatt gtttcaccct gcctcttcct ttctgagcat aatagtacta 2579161 ggtttgcatt attagccgga aaacatgcag ggtaaacata aaaatatgct atcgcttcat 2579221 tcgcttaact gactttttga tgcttccgtc ctcctcccat tgaagggcgc gatactcggc 2579281 atcatggtaa aaaataaacc aagcatcttt ttctgctgcg aacgcctgcc atttctgctt 2579341 ttgcgggata gaggtcatcg gataatcatc gtaagccagc acccatagcg gattgcggtg 2579401 ggcatgtgtc ggcatcagat ctgccatatg tacggcagtt tcacccgcat cctcgcatat 2579461 caggacactg tgtccgtcgc tatggcctcc ggtgtgatgc attgtaatac cctctgtgat 2579521 cgttaaggtg tcttcaaagg ttttgacttg gccagctaca gcctcccaat tttctttcca 2579581 atacgtattt ttcgacctga tattcggatg gcgcatttcg tcccattcaa cagctgatgt 2579641 ataaatcact gcattcggaa agacagagac gagccgttca ccttcatatt ccgttaaacc 2579701 gcatgcatga tcaaaatgaa ggtgtgtcat tgcgatcaca tctatatcgg caaccgttaa 2579761 tccgagtgca gctaatgagg gtttcacatt cgactcttgt gtcacgccat agtttcgttt 2579821 ttgtttatca gtcagcttgc cgtacccaat tccggcgtca atgatgatat tgagcccatc 2579881 cttttgaatc aaaatagggt ctgttcttag ttcaatctgg tttttttcat tgactggata 2579941 ttttttagac caaagcggct ttggcacaac gccgaacatg gcgcctccgt ccatatgcgt 2580001 cacgcctccg tcaagccagg tcaacgtgat gtttccaatt ttcattgttt ccattttcac 2580061 ccccccctat catcatggta gcaaacggcc cataaaaaaa acagactcct gtcagagtct 2580121 gtctttacgt tctccattca acctcagccc gatagatcgg ctggccgagt gcagagaatt 2580181 tttcttcata ttctgtcata atattgcctt ccagattgct gttatgcaaa tcgagactga 2580241 cgtatgtcag caggaggccg tactcagaga agctcttcaa agagtactca aataaacctc 2580301 ggttgtccgt tttaaaatga atcgatccgc ctttgcccat tacttcttca tattttttga 2580361 ggaagtggga atatgtcagg cggcgttttt catgccgttt cttcggccaa ggatcagaaa 2580421 agttcaagta gacccgtttc acttcccccg gctcaaacac atccgtcagc gtgtccgcat 2580481 ctatattcag aagctttaca ttctgcgctt cgctgtcttt tactttttgg acggctgtca 2580541 cgatgacgct tttaaataac tcaataccaa tataattgat gtcgggattt tgtttggcca 2580601 taccagaaat aaattggcct tttcctgtac caacctcgat atggatcgga ttgtcgttgc 2580661 caaacactgt gttccatttc cctttataat cagcaggatt gctgatggca atatctgcgt 2580721 tttcagccaa aaagtcatca gcccaaggct tgtggcgcat tctcatatga ttgacacctc 2580781 tatctattat ttcgactaac aacataccat gaattaaaaa gacccgcaag ctcgtttttc 2580841 cagtgtatct ctcttaaggc cgagcgcata aaaaaagagg gtcccgtctg ctggaacact 2580901 cctttcccat gtataaaaac gctctgtttt gaacaattta acccgtatga tactgaaggg 2580961 atgtgtaccg ttatgggttt acattatgag catcaagttc atttattgaa ggatatattg 2581021 actgaccatc aattggactg ctgcggaaca gtcgcagagt acgagcagct tgagcgtgtg 2581081 attaaatcac tgatggcaaa caccgagctt gattcaaatt tcaaaaacgt gcttgaagat 2581141 gtttaccgct acagccaatc aggaatatcg tccaaatcca tcgactcaca catacaagag 2581201 catcagaaca gcctgtctca atgggtagag caaatggatt cgtattcctg attaatcaac 2581261 aattcgtttc atgaggatat gcagctcttc cattgcatca tgaaattcct tatcattgcc 2581321 ttttgcttta tgccaggcaa tgaaagtaat tgtttcagat aacacatacc aagccattcg 2581381 caaccgaagg ctttctgtca gctctatgcc gtacatgctc agccagctct cccaagctgg 2581441 cttttcgacg tagtggtaca gcaaaggccc gaggtccatc gccggatcag cgatcatggc 2581501 gccgtcccag tcaattaaat acagctggtt gtcttcagac aatagccagt tattatgatt 2581561 gacatcacaa tggcaaacga ctttctcacc gaaatgcact tcatgcaggt gttcttccaa 2581621 atacttgatc ccttcttgaa tcagcggcga agattgctgc acagcaaata cagcctgctt 2581681 cagctgagac aaaagagccc ccgggttcag cggttctttt ccaagtctct tcagcatgtc 2581741 cagcaaggct tttgatgtgt gtattttacg aagcaattca gcaacgggcc gtccgctcat 2581801 gtctttaggc ttcagctctc tgccggtcat ccagtgctgg gccgtaatga cgtccccatt 2581861 ttccatccgt tttgtccaaa ccagcttcgg aacaatgcct tcggcggata aaacagctaa 2581921 aaaaggtgag ctattacgtt ttaaaaaaag ctgctgcccg ttatgtttcg cataatatgc 2581981 atctcctgta gctcctccgg cggggaagat ctcccaatcg ctacctagta attgtcccaa 2582041 ccagttcata tcaatgttca acccatcatt tcttaaaata ttttagaatt aaggctaatc 2582101 gtttctagtc tatccagcga atgccttttt cgtacgaatc gtataaaaat aaaaaagaca 2582161 gctattgaga gtctcatatg ctaatcaata gccgtccttt aaattttagc gctatagcac 2582221 aaacttcgtc aagcaaaact cttaagatct gatgctaaat ataagataac cgttccgatg 2582281 ccgtttactg caaccgtttt cttgatttct gttgggtctt cctgaaatcc tgatggatca 2582341 cataaaagcc gataaggtat gtcgtttggc agcctccact cgacggagtc tggactcgcg 2582401 tgatggataa caatgatatc tttccattcg tcaacctcgt caagatcata aagcctgtat 2582461 gcgataaggt gttcttttag cgtcaagcat tcaagatggc gctggatgtc tgcagcggac 2582521 ctaagacgga atgcaggatg cgcttttctc agcgagatca gcctgcggat atagtgaaca 2582581 tcttctttga atgtttcacg gcgatcccag tcgagctggt tgatgctgtc actggattga 2582641 tagctgtttt ccactccctg cttcgtccgg aaaaattcct ggccgctgtg aataaacggc 2582701 accccttggg caagcaaaat aatcgcggct gcaagccttt gcctgcttcg ctttcggctg 2582761 tcattttctt gaggaagcgc aaagctcatt ttatcccaaa aggtgtgatt gtcgtgtgat 2582821 tcgacataat tgatggactg gcttggttcc ggaacaatcg gtgctaatgc cttccatccg 2582881 gaagacccgg caattccatg catcacagct tgtgctgatt caccgttgcc gagcgcaaac 2582941 cctgttgcct taaggtgaaa ggtgttccct tttacagcgt cacgaaacat atcattaaaa 2583001 aagccgatgc ccggcattct tggcgcgttc gccaaagcag ctttctgttc atgcggcagc 2583061 ggtgtagcca ggtcccaccc ttctccaaaa agcaggattc cgggctttgc cttagttgct 2583121 ttctctttca tataaagcac ggtgtcaata tctaaaatcc cgaggagatc aaagcggaag 2583181 ccgtcaacat tgtattcttc aagccaatag accacgcaat ccgcaatgaa ttttcttgcc 2583241 atccttcttt ctgatgcaat atcattgcca acgccggtgc cgtttgatgg catcccacat 2583301 tcgtcgtgcc ggaaaaaata accgggcact gtcttttcaa agggggaatt ctccctctta 2583361 tacacatggt taaaaacaac atccagaatg actcgcagac cgtgctgatg cagggtattg 2583421 atcatttgtt tcagctctgt ttttctcgtt tgaggatcat gaggatttga ggcatagctt 2583481 ccctccgggg caaagaaatg aagcgggtta tatccccaat tgtatgcatc aagcggcttc 2583541 tcttcatcaa ctccggcaaa atcattcacc ggcagaagct ccacatgtgt cacaccaagc 2583601 tcttttacat acgctaatcc cgaagaactg ccatttgcgg tttgtgtatc agtttccgtc 2583661 agcgctaagt attttccctt gtttatcatg ccgctgtttt catggatgga gaagtcgcga 2583721 agatgcgtct catagatgac ggcatccaca gggtgtgaga atggtttaag aggagcagtc 2583781 catttcattt gatccgggcg caagacgacg cccttctctc catttacagt cacagccttg 2583841 gcatactggt caactgtttc catccattct gaattgttgc agatgcaaaa caaatactca 2583901 tatccgtgaa ggtcacctgt gaccgtgacg gcatagacgc ctttttccaa gcgagtcatt 2583961 tggaatgtgc gcccgctttt attggggtgt gaaagcttga cagcagctga ggttgcagca 2584021 ggcgcccata ctttaaatac ggtatgatcc gcggtataaa cggcgcccag ctctccgtca 2584081 taataaaatt cgtcatcaaa cgctgccgtc cggatgaccg cgccaatttg gagatccgtt 2584141 ttgtggccgc tggatgctct gacgcaatgg atttttccaa atgtcacagg atggtcggat 2584201 acgcagacgt acttgtattt tgcttcaagg gagtattcct ccctgacagc cagaggaaaa 2584261 tctgttattt ctgtctcaag ccgaaacggc ggtgtcatga tttccttttg ttcagcagga 2584321 atcagaacag taatgatatt catgtcatcg acatacgctt cgaagctgcg gcggatgctg 2584381 accatcggaa gctctctcct ccaaacacgt ttatgttttg attcttaggg gtgaaggact 2584441 agatgccaga cgaaacgggg tagtgcccat gatttctccg tcagcatgga acgggatttt 2584501 gtccttcgtg taaaatgtaa tgtccttcgc tttaaacatc gtaacgccat ccatctttgt 2584561 atgttttcca aatgccatga gacataaaag ccaatatttt ttcaaaaacg gctggttttc 2584621 aacgattacg atatcaaatg tcttctcgcg cggatttgct aggggcgccg ccttcatgcc 2584681 tcccccgtaa aacggatggt tggatacaac ggcaaaccag acatcatgaa attcgcgcgt 2584741 ctcgtcttcc gtcgtacaag ctaatgtaaa cggcttaaag gttgccgaag cgtgcaaatg 2584801 agaaagcgga tacacaagaa atcgaaggcg gagaaaaaga aaaacccgtc tcaacggaaa 2584861 ttccatcgcc tttttattga catatgcgtc aaacccgatc ccgatatgat tcataaaata 2584921 aagaatctgt gatttatcct gaaggaaatt gacgctccct aaatgaaagg ttcttgttaa 2584981 cgggcgcttt accttcttga tttcctgtat cagatcgatt tttttaatag agaaccctcg 2585041 cgaaaaatca ttatacgcgc ccgccggcac aaagctcagc tcaatatcgt caacatcttt 2585101 cagcccgttg acaacttcat gcatggttcc gtctccgcca atgacgatca ggcgcttcag 2585161 cttatattcc tgtatcgttg aaatctgtct ggcgagcacc tcggcgtgtc ccggatgttc 2585221 agttaaaaat gaacggtgct caacctttcg tttgatcaat tctttttgaa tggacttcca 2585281 aacacgcagg ccgtttcgat gtcctgctgt cggattaata ataaaaaacc aatggctcat 2585341 ctttctcacc tgcttatgtt atgagaaaac cgctcaaatc gttctctttt actccagcca 2585401 ctcctgtctg cgataggagt cagacatgca gtaagacaat agagcctttg cagcctttac 2585461 ctgatgatgt ttgatcggag cagtgttttt cttctgccgc tcaatccatt cttccgcgct 2585521 ccgcttatcc gctatttcta agccgtatgg cggctccggg taatcgatgt acgacgttct 2585581 gctcagaagc aattttcgaa ccggaatctc agcctgtttt tcctttacga tctttgacac 2585641 aaccgagtcc gtacgaaaca ggctaagccc tggatttaac actgatgcag tctgagaggc 2585701 tgttttcttg tcccaaaaac gatttttaga ccctatgtag acactgtctt cctcagcctc 2585761 taaaaaagaa acgcaataaa tttccagagg agaaataatc acaatgctta attcaaccgc 2585821 cgcctgctga attttcagca caggcttata cataataaaa taagaatcag gcagctgctg 2585881 ggtcagataa cgcaaaatgc ggtcctgctt cacttggttt gagagttgag atatttctga 2585941 aagagtagag cttgcccatt tgagctgaaa atcatataaa tgccttttat aaaaagaagc 2586001 aagcgccacc ctgctcttcg ggagccttac atgaatatct tcttcgtcct caaaccattg 2586061 gtgtctctct tcttgtatat cggcttttat ctcttctttt cttcttttca atgaaaattt 2586121 ttttcgtttc tgcaccggtt ccggttcttc agcactggct tgcctttctt catgctggcg 2586181 ctccgctgct tctactagtg aaagccagcg ctcttttttc aaacgtacaa actggttgat 2586241 ataatggtac ggatcaagct catatctcga tatataatca tgaattttga tgatttgtgc 2586301 catgtttgtt tctccactcc gcaatgaatt aagataattg aaatttgaat atttcctcgt 2586361 attttggtga ttggttcaag tgtatttgaa agagcgaaaa tcgttcagcc atcatcgaaa 2586421 cctcgccgct ttcaaacgga acatgagctg gaaatccatc ttcgcctgtc cattttcttg 2586481 ccagcgtcat atgaggatga tacggtcttt tttccacttg aaagccggcc tgaagtacag 2586541 cctgcttcgt atgttcccgc agtctatcaa gcgttttgtt tttctttggc tccagatgta 2586601 aaacgcgcgg ctttctgcgg tcgccgaata catctatctt gccaaactta attgaaaatg 2586661 gatcaatttc tgaagcaatc tctgctagcg aaccttcaag cttctttatt tgtgtctcat 2586721 ccgccgctcc gagaaaaatt aacgtgatat gatagtcaag cgggtgcacc catttttgaa 2586781 acgtcaatat cggttcgttt ttcgcagcct ggtagatcgg atttgcaatt ccctcaggta 2586841 tgggaacgcc gatgaaataa tgaggccgta tatctggcat ccgtctgaca ctcccttctt 2586901 tgacagctat tattttatca ataaagaggc tgtgcggata gaggaacagt gtatgaaaac 2586961 actctcgcac aaacgtttat tatgttagga tattatatga cacttgtttt attcagaaag 2587021 gaatgacaat gttgaaaatc gttgcaaaca cagctgatct gataggagat acaccgctag 2587081 tgagattgaa tcggcttcag ccggaaaatg cggcacaagt ctatttaaag cttgaatttt 2587141 tcaatccgag cggcagtgtg aaagacagag ccgcttatca aatgatcata gaagctgaac 2587201 aaaacggttt actcaagccg ggatcagtta ttatagagcc gacaagcgga aataccggca 2587261 tcgggctcgc catgaatgcg gcagcacgcg gatataaagc aatcttagtt atgcctgata 2587321 cgatgacgaa ggaacggatc aacctactta aagcttacgg tgcagaggtt gtattaactc 2587381 ccggagagga aagaatgccg ggcagcatca aaaaagcgaa ggagcttgcc gaacaaattc 2587441 cgaacagcta tattccaatg cagttcgata acactgctaa tcctgatgcg caccgaaaaa 2587501 caacagcgcc tgaaatcgcc cgggcaatag aggaaatcgg aaaaccgctc ggcgcttttg 2587561 tagcctcctc tggaacgggc ggaaccatta ccggaacagg tgaggcgctc aaagagcttt 2587621 ttccggatat cacggttcat gttgttgagc cagcgggttc gcctgtatta tccggcggaa 2587681 aacctggcgc gcataaactt gtaggaacga gcccaggctt tataccgccg attttaaatg 2587741 aagacgttta tgatgaaatt atcaaaatct ctgatgaaga cgcgtatacg acgacaagac 2587801 ggcttgctgc tgaagaagga attcttgtcg gtccttcatc aggcgctgcc tgcttcgcgg 2587861 caatcgaaac agcgaaacgc ctctctcctg acaaagttgt ggtctgcatg acagctgata 2587921 caggagaacg gtacttatca actgatttat ggtcatttat ttaaaaaaag gactggcttc 2587981 agcagaagcc ggtcctttta ttttgcaagc tcgtaaatgg cctgagcata taacgctgtc 2588041 gatctcagca ggtcatcaat ttcgatatat tcatcctttt ggtgtgcgct gtcagggcgt 2588101 ccggggaaca gcgggccgaa cgcgacaccg gcttttaagg atctcgcata agtccccccg 2588161 ccgattgaga ttaaatcagc ttttttaccc agctggcctt cataaacctt ttgcagggtt 2588221 ttgactaacg gatgatctgc ggacacgtga tgcggcttgc tgtctttgaa ttctcccagc 2588281 tcaaattcag atgcgctttc gaatgtatcg cggatcactt tgctttctgc tgtcacagga 2588341 tagcggatat tgatcccgag ctcgcctcct tgcccttctt tatagcgcag tgttccgaca 2588401 tttaatgtca gctctccgct gatttcatcc tcacagtcga tgtccagttt ttttcctctt 2588461 gtatcacctg agaacttatc tgtcacaact tgcacaaacc gctttcctgc atcgtcaagc 2588521 tcagtctgct ggagaaattc gcacaataaa atgccggcat tgatcccatt gttcggttcc 2588581 atcgcatggc aggaaagacc gtacatacgc aaaatgagct gtccgttctc tattgcagct 2588641 tccccttttt ggtccgtcgt gcggagcatg tctttaaatg aagacagaat ctcttcattt 2588701 ttcggccctt caatgacagc ttccgcagcg tcgggcacca tgtttaagcg aaggcctgat 2588761 tgaaacgaga caagcactgc ctttggttca gcttgatttg ggcggtgcgg aataagtaaa 2588821 gaagcatcga tgatcccttt ttccgcatta atgatcggaa aatcggcgtc aggcgcaaag 2588881 cccattgttg gcatttcttc atgcttgaaa taatgctcta cgcatctcca atcactttct 2588941 tcatctgttc cgataatcat tctgactcgc ttggacaggg gcaaattcat gtctttcacg 2589001 attttcagcg cgtagaatgc cgccattgtc gggcctttgt catcaatggc gccccttgca 2589061 taaatccgtc cgttgcggat ttcagctgaa aatggatcac tcgtccaccc atctcccggc 2589121 ggcacgacgt caacatggca aagtacgccg ataatgtcat cgccctcccc ccattcaata 2589181 tgacctgcga agccgtcaag attttttgtt gtaaagcctt ctttttctcc aagctccagc 2589241 aatgaagtca ggctggcatt taccccttct ccaaacggtt taccgggtcc ggcggttgtt 2589301 tcgtccatga cactgttgat tctcaaaaat tcctgtgtat cacgaattaa atcctctttt 2589361 tttctgatca cttcaacttc ccagttcata atgatcccct ttccgcaaga aatgacttgc 2589421 aaaaaccaaa taaaacgaat aatattaatg gtgttttgtt aaaacgttcg taattggagg 2589481 atactatgtt tcatctaaaa gagcagcaaa catccataaa gcaagaaatc atagcagggc 2589541 tgacgacctt tttcacaatg gtctatatcg tcgtggtcaa tccggtcatt ctggctaacg 2589601 ccggggttcc tttcgaccag gttttcaccg caacgattat tgcctccatt gtcggaacgc 2589661 tgtggatggc cctggcagca aattatccga ttgctattgc gcccggcatg ggcttgaacg 2589721 cttatttagc ctttcatgtc gtaagcgcaa gcgatggcgg catcacgtac gcaacagctt 2589781 tcagcgcagt atttacagca ggggttctct tcattattct atcgttaacg cctttaagaa 2589841 aacaacttat agaagcgatt ccaaacaatt taaaatacgg gatcacaaca gggatcgggc 2589901 tgtttattgc ttttatcggt ttgcgtcaag cgggaattgt ggcagctgat gagtcaaacc 2589961 tggtcactct cggcaatctg cattcacctg gtgttatctt aacgctggtc ggccttttga 2590021 tcagcgtggt cctgatggtg ctgaatgtaa gcggcgcttt atttatcgga atggcagcta 2590081 ccgctttgat cgcctttttc accggtcagc tccatttttc aaagggattt atgtcgcttc 2590141 ctcatttgcc ggaaggattg atgatctcaa atccatttac cgcttttggc gatgtcattc 2590201 atcacggcct gtacgctgtc gtcttttctt ttctattagt caccattttt gatacgacag 2590261 gcacgatgat cggagttgcc gagcaagccg ggctgatgaa aaacaacaag ctgccgaacg 2590321 tgcgaaaagc gctgcttgct gattcaaccg cgacgacagt aggagctgtt ttcggcacaa 2590381 gtccgacgac tgcatttatc gagtcttccg ccggtgtcgc agccggggga agaacggggc 2590441 ttacggcttt gactgtcgcg gtgatgtttg cggcttcaat gtttttcagt ccgcttgtca 2590501 gcgccttgtc aggtatagcc gccatcacct cgcctgcttt gattatcgtc ggcagcctga 2590561 tgatgggctc agtttccaat atgaactgga aagagatgga cgaggcattt cctgcgtttc 2590621 tcgtcattct agccatgcct ttgacctcga gcatttctac aggaatcgcg cttggcttta 2590681 tttcgtaccc aattgtaaaa gcggcgcggg gaaaatggag agagattcat ccgctcgtca 2590741 tcgttttcgc cattctgttt ttcatccagc tgtttatttt ataaggatag accaaaaaac 2590801 ccaaacgtcg ccgtttgggt tttttatgta aacaataaag agacagcggc cgctaaaaaa 2590861 caacaggcgg caaacgcata gtgcaggatg ttgatacagc tttttctggc ccgataatat 2590921 tcatcacttt ccttatcggt gccaattaaa aaaggggcat ccatgacctt gtcaaaaata 2590981 agcgtcagga tataacggca aacccctgtg tataccagca gcgcaatcac cttcagccaa 2591041 attggggaaa caaatatgag aacagtgaaa gctgacagta gcatgtacat ctgccttgca 2591101 tactcgccat tcctcagcat aactttaaaa aacaactcct tatagcctgt gcagatcgtt 2591161 cgtcttttaa atatcctttt tgaatttcgg tataataatg gttttcttct catcctgtct 2591221 tttacttttg gcattcccgc ctcctgactc atcatcatca caagtcctgc aagggcaagc 2591281 ctgctttttt tctcttcagt cacctcagct tcaaaagccg tgaacgaggc tgtctttttc 2591341 aaactgcgga taactgagaa aaacaaaaat aaaatgccaa aaagcgcaag caagtgccgc 2591401 tcagtaaaaa caatcaggat agcagaacca gcaaaaagaa tagctctgac aagggtatcg 2591461 ccaatccatc tcgaaatgga gcgcggcttt ctgatcctgt cttgctttaa ggataaaaag 2591521 aatatatgaa ggccaaacaa ataacacaat agagcagtgc tttctgcgaa tgtgatgaga 2591581 acagaatgac tgatcaaggg aaggacaatg aaaaagagaa gcagccattt agccagcgtg 2591641 gccagaaaag aatacaaaag cgcataccgt ttgagctgat agatgatttc cttcttttgc 2591701 agcaaaaaca ctttgtccgc ttccattaaa aatgtacgaa tcgaacctgt aaacatgatc 2591761 agcacacaca cagcatacag ccatctccat tccgccactt cagaccactc ataaagaagg 2591821 cctcttccgt tcatcaaatc aatatactga tagatgacaa aagcaatcgc cggcaaaacg 2591881 atatagagag cgactgtcca gtcaatgacc gcatgcaaca ctttaaactg atacttataa 2591941 tagtcaaaca gccttcgaaa aaagagcgta cgcccgttca tagccgatca ccttgaactg 2592001 ccttataaaa acagtcaagc aatgactgcc cctctaatcc ggtcttgtcc tgaacatctt 2592061 ttaacgtgcc ttggagaaat aatgaacctt tctcaatcat ataaaaccgg tcacagattt 2592121 tttccgcggt atcgagtaca tgcgtgcaca taagaattcc ggctccacgt tctttttcag 2592181 ccttaagcat gtccacaaag cgtttcgtcg atatcggatc aaggccgata aacggttcat 2592241 caatcacata catatccggc ttagagagaa aggcctggat aagcattagt ttttgctgca 2592301 tgcccttcga aaaggtgaca ggcagctcat gtttgacatg atctagcgaa aacgtctgca 2592361 gcaggctttg ggcccgatgc gcaaattcac tctcttcaat gccgtgaagt gtgctgatca 2592421 gatccaaatg ctcccacagc gtcagttctt cgtagaagga cggatgctcc ggaatatatg 2592481 caaatgaaca gtcgttccag gcaatatgcc ctttaaaatc ttctgaaagg ccgagtatcg 2592541 ccttgattgc ggtgcttttt cctgcgccgt tagctccgat cagtccaacc agttcccctt 2592601 ttctgacttc cagaaaaaca tcggtgagca ctttttttcg gcttgtatac ccggcctgtt 2592661 ctattgaagc ttcaagcaaa tttgtcaaaa ctcactcacc tccaaaattt actacgaaat 2592721 agaataaaaa aagtttcttt aaccataata atattgagcc gaaatacata gtaatccaac 2592781 aaggatggct gcccaacgcg aaattggaaa aaattaatag gagttatccc tagattcatc 2592841 actgcaatat cgtgtataat gagggcgaat tattttaaca attacagatg tctgcctttg 2592901 ttgctatttc gtacgcagtt gatagtcgtg agttgtggtt agtcaagtcc atccgatctt 2592961 atgataggga gtggtttttt gaaaccttca acaaaccgta tgctaactcg aatcaaatca 2593021 gtttacatgt ttattcaaga aaaaggtctt gtgacaacac aggaactggt tgacgaattc 2593081 ggcattacac ctagaacgat tcaaagagac ttaaatgtgt tggcatataa tgatcttgtt 2593141 catagtccaa gccgtggcaa gtgggagaca acgagaaaga aagtaaagat tacctcataa 2593201 attgaaaatt acatagggcc gcctgagagc ggtccgatag ataacagggc gaagaaacta 2593261 ctgagccttg tttttgtgtg cttataaata aaaccccgca ttcggtatgc ggggtttttg 2593321 tcatgcttgc ggctcattta gcaaatgaag ctcttcctct gtcagctcac ggtattctcc 2593381 gggtgccaga gcgggatcta gggaaacgcg tcccatcgaa agccgcttca gataaaccac 2593441 ttcattgccg actgcctttg ccatttgctt gacctgatgg tattttcctt ctgtaattgt 2593501 cagatatata acggtattgc cactgtcgtt tgttttgatt tccgcttttg ccggctttgt 2593561 tttatagccg ccctctatgt agacacccgt ttccaaatcg gaaatgtctt cccgagaaat 2593621 ctgtgatttt aaatggactt catacgtttt tggaacatgc tttttaggag aaaggagccg 2593681 atgtgcgagc tggccgtcat ttgtgagcag caaaaagccc tctgtatctt tatcaagcct 2593741 gccggctgga aatggctcaa atctcatctc ctccggcgtc agcagatcga ccactgtttg 2593801 ctgccggctg tcctcagtcg ccgacagcac gccctgcggt ttattcatca taagataaat 2593861 gaactctcga taatcaaccg gttccccgta tacggtcacc tcctgcgtat caggatcaac 2593921 gtgctccttt acatctttgg caggtttgcc gtcgatcatc acggctccag ccttcacaac 2593981 ggctttgact tcttttctgg aaccataccc gctgttggca agcagcttat caagtctcat 2594041 tcccaatctc tcctttataa aagaaagccc gcagcatgcg agccctcagt ttcatcatat 2594101 ctagttcatc agcctgcatg tctgcctttc ctaaagaaac ctggcaaacg gcggcctaaa 2594161 attttctgca aaaatcctaa tcggtagccg caatacaggt agacagctcc gccaacagcg 2594221 gccgcgatca ccacaacaat cgcagcttgc atctggccat cctgatagga aataaagaag 2594281 cctaataccc actgcacgat tttcacggca atacccataa tggctgataa gaccagcatc 2594341 aaaacagttc gtttaacaag tatcttatac gaatagcctg catggcgctt aatcatgata 2594401 aacccatata aaagggaagc gatatatcca agcgccgtcg ctaaaatcgc tccgtcagcc 2594461 tgcatcagct tgatcagcgg aacattcagc acaagcttga tcacgacacc gatcacaagg 2594521 ctgacaaccg caaatttttg cttattgatg ccctgcagaa tagctgcgtt gactgtaaac 2594581 aaagagaaca gaattgcgac aggcgaatac caaagcaaaa tgtttgcccc cagttcagga 2594641 tgaaggctct ctgacccgta aaagaacgta tacgtcggtc ctgacaatag agagatcccg 2594701 acaacagccg gaataattaa aaacaggatc gtctgcatcg tttgattaat ctgctgattt 2594761 aacagcttat agtttccgct tgtaaacgat tcagtaatcg ttggaattaa tgtcagtcca 2594821 aaagcagttg ctagggaaac cgggatcatc acgagcttct gaacatacag ggttagaatc 2594881 gcaagcatgt cctggctgat ggcttgatga ccggcttcaa tcatcgcttt gttaaacgta 2594941 tttgtatcaa tatagttata caaagggatg gctagtccga caaaaacgta cggagcagca 2595001 tagctgaaca gctcgaaaaa cattttcttg tagcttaggt ttgctgtcgg acccgtattc 2595061 ggcatcatcg ccagcaggct gcccttccgt ttgttccaat aaatataaag cacgaccagc 2595121 cctccgaagg caccgatcag cgctgcgaag gttgcatagc ccacagcgat gacaaggccg 2595181 ccgttgaaaa ccttcaaaat caagaatgtc gcactcaata gaaagatgat gcggacaatc 2595241 tgttcaacga cttgggaaac agctgtcgga cccatcattt ggtgcccttg aaagaatccg 2595301 cggacaaggc tcataatcgg tacgaccaaa agcgctaagc tgaccatgcg gatgacataa 2595361 acgacatgat caattgtcag gccgttatta tccttgcctc ccagcgatat ttccgcaaac 2595421 atcggagccg atagatacag aatgaaaaag gctatcattc ctgtgactag cataaccgac 2595481 atgcccgcct tgagcatttt cctgcttgtc tcataatccc cttttgaatt atatttggaa 2595541 acaaatttag aaacagcggc cggaaagccc atcgtagcaa tattcaaaaa taaagtgtat 2595601 tggttgtatc cgtattgaaa taatgcaccg cctgtcgccc cgaccataat gctgaaggga 2595661 attaaataga ccatccccag aatccgcgat atatatgtac cgagcgttaa tacaaacgtg 2595721 cctcttaaca gtttgcttga catgtttctt catcaccatt ttctacgaag attcaacttt 2595781 tctattttac cacaactggg catttagacg gtaataaata caaaagcaat cctgtgaaca 2595841 ttcatgtccg cggcaaaaga cgtttaagga gcggctttct ttcgctataa tagtactgcg 2595901 gacgggtgtc cgcacacgaa atgaaaagaa agttgatgat aaagatgaaa caatatgacg 2595961 taatcgtaat cggcggaggc ccttcaggct tgatggctgc gattgcagca ggagaacagg 2596021 gcgctggcgt gttgctgata gataaaggaa ataaattagg acggaaactc gcgatttccg 2596081 ggggcggccg ctgcaatgtg acgaaccgcc ttcctgtgga agaaattatc aagcacatcc 2596141 ccggcaacgg gcgtttttta tacagcgcgt tttctgaatt taataatgag gacattatca 2596201 agttttttga aaacctcggc attcaattga aggaagagga tcacggccgg atgtttcctg 2596261 tgaccgacaa agcccaaagt gtcgttgacg cgctgttaaa caggctaaag cagctccgcg 2596321 taacaatcag aacgaacgag aaaattaaat ctgttttata tgaagatgga caggcagcag 2596381 ggattgtgac gaataatggc gaaatgatcc atagccaggc agtcattatt gctgtcggcg 2596441 gtaaaagcgt gcctcatacc ggaagcacgg gagacggcta tgaatgggct gaagccgcgg 2596501 gccataccat aacagagctg tttccgacag aggttcccgt cacttctggc gaaccgttca 2596561 ttaagcaaaa aacacttcag ggcttatcac taagagatgt agccgtcagt gtgttaaata 2596621 aaaaaggcaa accgattatc acacataaaa tggacatgct gtttacccat ttcggcctct 2596681 caggacctgc cattctcaga tgcagccaat ttgtcgtaaa agagctgaaa aaacagcctc 2596741 aagtgccgat cagaatcgac ttgtatccgg atatcaatga agaaacgctt ttccaaaaga 2596801 tgtataaaga actgaaggaa gcaccgaaaa aaaccattaa aaacgtgctg aagccttgga 2596861 tgcaggagcg ctatctccta ttcctgctcg aaaaaaacgg catctctccg aacgtatcgt 2596921 tttctgagct gccgaaggat cctttcagac aatttgtaag ggactgcaag cagtttactg 2596981 tcctcgcaaa tggcacactg tcgcttgata aggcatttgt cacgggaggc ggggtatctg 2597041 taaaagaaat tgacccgaaa aagatggctt ctaaaaaaat ggaggggctt tatttttgcg 2597101 gtgaaattct ggatatccac ggctacacag gcggatacaa tattacctcc gcccttgtca 2597161 caggcaggct tgcagggcta aatgccgggc aatacgcccg ttcttaatca ttactcttta 2597221 aatctcttgc cgccaaactc acatttgaac attccccgca ttcatgttag ggtgagactt 2597281 gttttgtttc acctgattgc ggggtaattt taagagagga atgagctgcc atcgtacgac 2597341 catactaagc ctgcgagcaa gatataggcg tacacaaaaa attagagggt gagaaatgtt 2597401 gaaacatata tctagtgtat tttggattgt gattgcaatc acagctgcag ctgtattatg 2597461 gggtgttatt tctcctgaca gcctgcaaaa tgtgtctcaa tcggcacaag catttattac 2597521 cgattcattt ggttggtatt atcttttagt tgtctctttg tttgtcgggt tttgtctctt 2597581 tttgattttc agcccgatcg gaaaaatcaa actcggaaag cctgatgaaa aaccggaatt 2597641 cgggttatta tcatggtttg ccatgctgtt cagcgcaggc atgggaatcg gcttagtatt 2597701 ctacggtgcg gctgaaccga tcagccatta cgcaattagc tctccatcag gtgaaacaga 2597761 aaccccccaa gccttcagag atgcactccg ctatacgttt ttccactggg gtttgcacgc 2597821 ttgggccatt tatgccattg tggcattatg cattgcctat ttccaattcc gcaaaggcgc 2597881 acccgggtta atcagcagca cactgtcacc gattctcggg gataaagtaa acggaccgat 2597941 cggaaaggcc attgactgta ttgcagtttt cgccactgtt gtcggggtgt caacaagtct 2598001 tggtcttggc gcaacccaaa ttaacggcgg tttgaattac ctgttcggca ttccgaatgc 2598061 gtttatcgtc caattggttt taatcattat tgtgacagtg ctctttttac tttctgcgtg 2598121 gagcggactc ggaaaaggaa ttaagtattt aagcaacaca aacatggtat tggccggatt 2598181 gttaatgttg tttatgctcg ttgtcgggcc tacagtgctg ataatgaact catttacaga 2598241 ttctatcgga caatacattc aaaatatcgt tcaaatgagc ttcagactga caccgaacga 2598301 tcctgaaaaa cgcgaatgga ttaacagctg gacgattttc tattgggcat ggtggatttc 2598361 ctggtctcca tttgtcggca ttttcatcgc ccgtgtatcc agaggccgga cgatccgcga 2598421 atttttaatc ggcgtcttgg tgacaccttg tattttgaca tttctatggt tctccatttt 2598481 cggcgtatca gccatggatc tccagcaaaa aggcgcgttc aatgtagcaa agctgtccac 2598541 tgaaacgatg ctgttcggaa cacttgatca ctatccgctg acaatggtga catcgatcct 2598601 tgcattgatt ctgatcgcag tattctttat cacgtcagct gattcagcta cattcgtgct 2598661 gggcatgcag acgtcgtacg gttctttaaa tccggcgaat tctgtgaaac tcagctgggg 2598721 tatcattcag tccgccatgg cggctgtgct cctatattcc ggagggcttg ccgctttgca 2598781 gaacacagcg attctggcag cgctgccgtt ttctatcgtt atcctgctga tgattgcctc 2598841 tctctatcaa tcgctctcaa aagaaagaag agagatcaaa aaagcggaga aactcgataa 2598901 accaagaagt ccaagagtga aaaaagcata ttaacaaaaa agatctttcc gcgcctgcgg 2598961 aaagatcttt ttatttgcga tataaaataa gggcggaaaa acagtaaagc tgctcgccgt 2599021 ctgggtcgca cgccgccgaa accgtatatt tgatatctat cagctgctcc tccgatatcc 2599081 cttttaaaaa tgaattgatt tccgtttgta agtctttttc atgctcttca tcaaataccg 2599141 ctaccttcag cattttatcc gctctccttt ctctatcaat ctattccgtt tggaacagcg 2599201 ttatgataga gaaatgatga ttatctcgtt tccggataaa aagctttccg tatatgggat 2599261 ttcctctgtg gctcgccgcc gtgctgctcc actttcagca gcacggcata aacaatgcgc 2599321 atatggcagt agctgataag gctgacgctg aaaaaaggga caatgcccgg caggtacgca 2599381 agcaagaaaa agagagcaac agtcagcgca agcatagtaa gcgtatattg caaatacgcc 2599441 acactgagca agagcgaaaa tttcacatac agacgttttt tccagtcaaa atggacaagc 2599501 agcggaaaca cataaaaaag catggatacg aacaaaaagc caaatatcat aatggcgaag 2599561 cgcaggatgt gcagaaggaa atgacttgga taaattaagg ccaaatcaat ataaatgatc 2599621 actccgatga gcgccagtac agcgccgagc agatttgaac gaaaaaattc acccttgtat 2599681 tcctgccaaa acgttttgag caccggaacg ttgtcctgcc cctggatcca cttccgcatg 2599741 acagcgaata aagccgcggt cgcgggcatg atgccaaaca cgccgagacc gagcaacgta 2599801 aaaaacagcc acagcaagtt tgtatacgca aatctcataa tccattcgca aaaacgcagc 2599861 atccgtccca gtgagccatc atgttccatg gcgccccctc cttttttgca ttatacattc 2599921 tgcatctgaa aaagctcttt catgccgatc ggcttctttt cggcaaccga gcgccacatt 2599981 ccctcaccaa ccgcgatgga gtaggctcca gcttcagccc cggctaaaat atcatagcgg 2600041 cgcagcgggt ctttccctaa aaaaagatcc tcaagcaaaa gcggatcacc tccgccatgc 2600101 cccccttcat ttttgaccac ttgtatcgtc tgctttgatt caaaaagcgg atagtattcg 2600161 attgtctgct caggaaaagc aaacggaatt ctggaaggtt cgtgaaattc atttgattca 2600221 atacgtcctt ttgtgccgtt gatcgtcagc cggtagcctt catacggggc cgaaaaaata 2600281 atcgagtagc ttaacagtgc gccgccatca tatttgactg ccgccacgta cgtatcctcg 2600341 atgtcaattt cctcgtcaaa aatacacgcg tcaggcctgt atgcagtata taagctggac 2600401 tggtctcctg cttcaagatg atcatccttt atagaagctt tagaggaacg gggatgccac 2600461 cttgaatagt agtggcattt ttctttaaca cggcacgtcc cgcaaaaacg cccgtcttct 2600521 tccggcaagg ggttccactc actgtccggc ccatagtaat tcaaggcgcc ataagcaaat 2600581 acctcttccg gattttgccc gagccaccaa ttgacgagat cgaagtgatg tgttgattta 2600641 tggacagaaa gaccgccgga aaactgtctc gacctgttcc agcgtttaaa atagctggcg 2600701 ccatgatacg tatcaatata ccaatttaaa tcaacagaag tgaccctgcc tatttttccg 2600761 tccagaatca tttcttttat tttccgatga aacgggctgt agcgatagtt aaacgcgacg 2600821 gtgacttttc cttcgctttt ggcctccgct tcaagcaccc gattcgcatc ctgcactgtt 2600881 gtcaccattg gtttttcagt aatcacatct gtattccact gaaggctttt tacaatatat 2600941 gcgacatgcg tatcgtccct gcctgccaca atgacgatat caggctttga gacgcgcatc 2601001 atctcgtcaa aagcatcttc gctaaactca ggcacgtggg ccagctcggg aaatttcttc 2601061 ttgcaaacgg caaaacgttt cggatcggca tccagcaatc ccgtaatctc ataatgagtt 2601121 gaaaaccgct ccatcagtgg tttgataaac atactgaatg ctctgctgct caatccgcaa 2601181 aagacgatgt tcttcaatat cctcacctct atcgggcttc agttagttga gaaatcagct 2601241 gcagcgcttc ctctgttttt tcagcataca cagggataaa cgccgccata tcgcgattca 2601301 attgaaaaga atagccgttc agctgttttt tccctttttc gatctgaacg gcatagatcg 2601361 ttttttctcc tgttttttta ttaacagttg tataaggaga tgttttttca ggaggcaatc 2601421 cgtttaacgg ctgaaaattt tccggatcat cgtaagcttg aaacatgtct tcaggcacga 2601481 tgaaaacatc tccctcatgg gcggtaattt cagtcagcag tttttcctga aaagctggaa 2601541 agatatcgac cttcccggca ttctgctcgg cggccttttt tattttttcc tgtacgccag 2601601 cctgcatatc agaaaagaga atgacatgca ttccgtccgg cctgcttgag catgatgcca 2601661 aaaagagcac tgagacgatc acacacaaag ccgtacgtat cctttttgtc atttccccgc 2601721 tgacctaaaa agaggctcca gctctgtcat agctaaaata aacgcgccgg ctccgtgcag 2601781 atcgtttgtg cttctttcgc ggctgacata atagtcatag aaaccggctg acgttccgac 2601841 acatatgtct ttgacgagaa acgctccgtc ttctgatgtt tcggttttat gctgaatcaa 2601901 gccttgatac gcttttagca gtgttgtttc gtaagctctg tctagatagc ctttattgat 2601961 tccttttgcg attgcgtaca tgtacagaca ggatcctgag ctttccagcc agttatcaga 2602021 cctgtctccc ttatcaacga tctggtacca taaccccgtc tctttgtctt gatagcgaca 2602081 gatgctttta atcatgtcct gcagcgtgtt tttccacaca tgacggttcg gatgcttctt 2602141 cggcagctct tcaatcatgt cagcaagaga catgacgtac cagccgatgg aacgtgccca 2602201 aaattccggt gaacagcctg tctcttcatt ggcccaaggc atttttttcg cttcatccca 2602261 ggcgtgataa aaaagtccgg tttttgcatc cttcgtatgc tttctcatca atgactcctg 2602321 aagcacaacc tgatcaaaca gctccgtctc ctgcttcaga ttggcatatt tcagtgcaaa 2602381 cggccccccc atgtataagc cgtcaagcca catttggtaa ggataaccgt ctttgtgcca 2602441 aaaaccgccc tcagacgtcc ggttcagtgt tccatataag ctgcgcagcc tttttgccgc 2602501 tttgacatac cgttcatcct tcgtctgctc gtataatgga aaaagaatga gacctgcttg 2602561 aatggcgtcc agttcatctc ttctaaataa tagattgcca ttatcatcga ttaagagatc 2602621 tgcataagcc ttcgcatact caaaataccg cttttccccg gttgcttccc acagccgcaa 2602681 tacaccgcat aagaaaacac cctgatggta gtgccagcgg tttgcaggtg gcagctcctc 2602741 gactgtgtac gtgttcataa tggtgtttgc caatgcctcc gcgtacgtaa gaggcgattt 2602801 tacagcgatt gattgatcca ttgatcccat ccctttccta ataaattcct tcctcgccaa 2602861 atttcttcgc caaacgattc gctagcatga ccaaaatcag cccgaccgcc gctttaaata 2602921 cgccgactgc tgtactgtag ctgaattggc cctgtttcag ccctgcagta taaacatacg 2602981 tatcaaaaat ttccgccact tccctgttag tcgcatttaa cagcaaatac acatgctcga 2603041 agccaagctc cagcgtgtct ccgattttca aaatcagcaa aacgacgata acgcttttaa 2603101 tggcgggcag cgtaatatgc cacatttgcc gcagccgtcc cgctccgtcc attttcgccg 2603161 cttcatacag ctgggggtca accgctgtaa tggccgccag ataaatgatc gtcgaccagc 2603221 ccgcttccct ccagataacc tgcagaatat acaggggccg gaaccattct tcgttcagca 2603281 gaaaattgat tttttcaccg ccaaaaaaca caatcagttc attaatcaag cctccgtcta 2603341 ccgttaaaag cacaaacgaa agcgatacaa caatgaccca agacataaaa tgcgggatat 2603401 aaatcagcgt ctgaacaaat tttttaaaga gagcaatccg cacttcgttc aatagaagcg 2603461 ccagcagtat cggcaccggg aaaaatatgg ccaggttcaa agcaaataac acgagcgtgt 2603521 tttttaacaa gagaaaaaat gtaggctcag taaacagcct gataaaatgc ttcagcccca 2603581 cccactcact gcccaaaatg ccgaggaacg gctgataatc ctgaaacgca atcacaattc 2603641 cccacatcgg gacatactta aaaagcaaaa aataaataca ccccggcaaa atcatcaagt 2603701 acaaatattt ttgttgaatc agcttgatta gtaagcgctt tcttttttct tttttaaaaa 2603761 tgactgcatc aacagccggc gcttgcgctt ctgctgtttt cattttttcc tagcctcctt 2603821 tcacggattc ttgcattcac tgtagcgcag caggcaaaag tccgtctaca atcatatgat 2603881 cacatcctgt tttatccctt tataatcaag ggttcagccg gtccacctga aaaaaagaca 2603941 ccgatattag aaaatgatta ttgacaatat ctatcaatct ttggattaat tgtattaagg 2604001 tgaagtggat gttatgaaat ggggggtttt atgaaaagaa gccaatacaa gttttactac 2604061 aaactgatca cgtttttctg cctgctcagc accattccgg ttattttggt cggattattt 2604121 tcgtacgagc actctcagaa aacggctatt tccaacgttt cggaggaaaa attcgacaca 2604181 ctccagcaga cccagcaaag catcgagcat atattgaaaa ccgtcgatca ctctttaacc 2604241 cactatgtga gttcgccgcc tctccttcgc acattgtccg agcctttgca ctcagaccaa 2604301 tttcaaatct ataaccaagt gaaccaagag ctcaattatc tgcaaagctt tgataccgat 2604361 ctgtccaaca tgacgttagt cagttatacg aaaaaatggt acatgaacaa ttccggtttg 2604421 taccgtttga atacagacac tcttcatgaa gcagcctcag cgtacacgaa acaaaaagcg 2604481 agccgctcct attggacgct tgaggaaaac aatcatttga tttcaaccaa agaaggcaca 2604541 gcagaaaact gccgctacaa tatcaattta attaagcagc ttcctttgaa cagcacaaat 2604601 acaaagggat tggccgccgc aagcatcccg agctgttcgc ttgtcaaaaa tatgcccggc 2604661 tattcaaacg ccaacaacct gtttatcatc gatgaaaaag gcctcatcat ccttcataac 2604721 aatatgtctg acgttggtga atctcttcat aacgacggct ttgtccaaaa agtgctggcg 2604781 caaacggcca atagcggaca gtttgaaaca gtgattgacc ggattcatta taaagtcacc 2604841 tatcaaaaat ctgactataa tgcatggact tatttttctc tcgtttccct gcctgagtta 2604901 aaaaaagaag ccaaatcaat cggctggatc acttttgcag tatgcctcat tttgttaacg 2604961 ctttcattgc tgttctcttg gcttggctcc cgccattttt acaagccgat cagggtgctt 2605021 tacgaatcat tcgcaagaca tggagccata caagagaaac aacagcctcc tcaaaatgaa 2605081 tttgagttaa ttgaacagag ctttaagcag ctgaaggaca gaaatgacga ccttgaagaa 2605141 acgatgaagc agcaggccac tcatctgcag caatatttta tggtcaggct tatgcttgga 2605201 aaactgacgg atgaggaggt tgataaccgt tttgaaagcc tcggcttaaa gcaaaattgg 2605261 cggcaccttg ccctgcttgt gctccaaatt gacacactga atcatacgcc ttatgagaaa 2605321 aaagatatgg atctgctttt gtttgccgtc aacagcctga ttgagcgcaa catcccgacg 2605381 gacaaacatc ttgcccccgc cgtagttgac aaacagcagg cgacgatttt gatcaatcaa 2605441 agcgggacaa aggaagaatt catggctgag ctgaatgaga ctgcaaggat gattcaggaa 2605501 aaagcggaag ctgagctgca gctgtctgtc agcatcggca tcagccagcc gtttgatgtg 2605561 ctgacaaaag cgaaaacagc ctatgcggaa ggctcagaag cgttgaaata tcggctgaaa 2605621 gcggaaaaca agtcgatcat cttttacgaa gaccttgacc agaaaaaaac cttcaaaacc 2605681 cattttccaa agcagcttca gcatgagctg ttcgatgctg tcaaagcagg agacaaggag 2605741 aaagcggata aatgcctgca cgcgatttta caagccattt tcacccagaa caccaacccg 2605801 tatcaatttc aaatcgccat cgcccgtttt ttgaaccatg tgattgagct gatgcatgtg 2605861 cttgggatcg aattgtttga gcttgaagaa aacaaaatgc tgtatgacca aatttttgag 2605921 ctgaaaacgt tcgaggatac cgaaaactgg ctaaagaatg agtttattga tccgatgaca 2605981 gacaaagtga acgcccgcgc ggatgcccag tacaaaaata tttccgacaa catcattcat 2606041 atcatccatc atgagtttga atccgaattg acactggacg aaatcgcacg caggctgcat 2606101 tacaacccaa attatttaag cagtattttc aaaaaagaaa tgggaatttc attcagcgag 2606161 tatgtctcaa gctaccgaca ccatatggcg aaaagctggc ttgccgaaac cgacatggcg 2606221 gtcaaggaca ttgccgaaaa gctgaaatat aaaaactccc aaaacttcat cagatcattt 2606281 aagaagctgg aagggattac accgggaaac taccgccagc aaaaaagaag catgtaaaaa 2606341 acccaaaacc gcttgcgcgt tttgggtttt tccaatgtta ttttgcttgt ttaaacgctt 2606401 cttcgtattc ctgaataatt tgttttcctc cgcttgactc ccatttttcc acttctttat 2606461 cgaactggct ttctgtgatg tctccaatca tatatttgta ggtcgcgtca tcaatgattt 2606521 tcttcagttc gtcaccccgt tccgactccg atgcggaata caggctttca gccgggtttg 2606581 agacgataat cttttcattg tcctcggtca gctcctcgta cgccgtccga agcggatctc 2606641 cagtgttttt taagtaggct ttatcaatgg caattaaagc ggacagcggc tgaatatcag 2606701 tctgccagtc ttttacctgg ctttctttgc gtgtaaacgt tttgtcctca cctttgttgt 2606761 aatgaacgcc gtcaatgcca taagtcatca ggctatagac atcttcttcg gcaattcggt 2606821 caaaaaacgc caagatccgt ttaagctcag cttccgtttt cacactcgtt ttcgggaaag 2606881 caaacacgcc gttatggcct cctgatgccc atacccgctc tttcccatct gggcctttta 2606941 tgcggttgat gatctcgagc ttcatcgatt tatcagaggc atggtcgcgc agattgaccg 2607001 catctaccat attgccaata taaattccgg cttttccttg agaaaacagc tcttgctgct 2607061 gggttttgct tgtgacggga aaatccttat tcatataccc gttatcacgc agctttttca 2607121 tatagttcat cgtgtctttg tattcctgtg tcatgaaatc aggcgtgaat ttgccgcccg 2607181 attccttcca atctgtcggc atgccttcat acgagccaat cgttttaaac gcgccgtaaa 2607241 tcaagtcatt acggtctgcc agcccgaatg tatcatcttt cccatccttg tccgggtcgt 2607301 cctccgtaaa tgctttggcc acttcataaa gctcatccaa cgttttcggg gttttcaaat 2607361 ttaaattgtc cagccagtcc ttccgaatga cgatcccctg tctggaaagc gggcgctctc 2607421 tgtatatccc gtagagcttg ccgtcaattg tcacattttt attaatgagt ttgttcattt 2607481 tgtttaagtt gggataatcc ttgatataat cgccgatttc ccaaaacatt cctgaccgaa 2607541 aggcattcat gactgacgaa tttttaatat cctggatggt cacgatttgc ggaagattgc 2607601 cggctgcaag cgctgcattc agcctgtctt ctttcaccgc gtctggaacc caggtgatgt 2607661 cgagttctgt atttgtcagc ttttcaattt ctttaatcgc cctgtctttc ggcggctgct 2607721 ggtgatacaa aatcgccatc caagacagct ttacctttga atctgggcca gctttgcctt 2607781 cagccgaaga ctgatcagtt cctttacagc ccgccagcac tccgccgagt gccagtacaa 2607841 gcacaatcaa aagcaccctc catttgtttc ccatcgtacc cctccgtttc atatttcttt 2607901 atcctttgac agatcccagc aaagctcctt ttgcaaaatg cttttgtata aacggataga 2607961 caagcagaac agggatggtc gccaccacta tgaccgccat tttaatggtt tgctcaggcg 2608021 gcgggctgcc cgaccccatt tcagacatat ccccctgcat accgcttgat acaatgacga 2608081 tttggcgcag aagcacctga attggccatt ttgctgaatc atttaagtac aagatcgctg 2608141 tcatatacgt gttccaatac gtgaccgcat aaaatagtga aatcgttgcg atcgcaggaa 2608201 gagacagcgg cagcacaatt ttaaagaata tgcccagatc attgcacccg tcaattttcg 2608261 cggactcttc caggcttgac gggatatttt gaaagaagtt tttcagaatg atcaggttaa 2608321 aggcattaat ggctgtcggc aaaataagcg cccagtaaga atcgagcaat ccaagcgatt 2608381 tgaccacaag gaaagtcgga atcatgccgc cgctaaacag catcgtaaat acgacgagaa 2608441 acatgagcgg ctgccggccg attaaatcac ggcgggataa cccgtaagcc atcagtgacg 2608501 aaagaaacat gctgaccgca gtgcctatca ctgtcacaaa cacagaaaca agcaaactct 2608561 tataaataat atctgttgaa aaaatgtagc gataagcatc tagcgaaaaa gtggtcggta 2608621 ttaaaataaa ttttttcgac acgacttctt ctactgtggc aaaggatgct gcgataacat 2608681 gaatgaacgg aagtacgcat attaaagcga acatcagcaa gaaaccataa atcaacatat 2608741 caaacagacg gtttttcagt gaatgtgcga tagctcccac ctccctttgt aagcgttatc 2608801 atatttttgg aaaccgagct cagcatgtga cgatatcgtg tctaaaatgt agcaaatctg 2608861 tgattgccat gtctataatc atttgaacag tgtccccggc cgggcggggg ctgccgcgaa 2608921 ttgagaccga taacaaaaga aaaagagcat aatcttagaa aatgattatg ctccgttctc 2608981 ctcctcgttc agaagttcag ccgtattgat ttgtggcgaa aacccaagtt cattcacggc 2609041 agattcaatg gaccatggcc ggcccggatt atcagagacg gcgtaataag tgccataccg 2609101 gatgttggtc tcaatggcgg ctttgaaaat cgacagcaga tcggggtgag aaagcagtgt 2609161 ctttttcgtc cgttcttttt catgcagcgt atccatttca tctgtcacga ctgttccgat 2609221 tcgaaggttg attactgata gcttattttc caaataaaac aaatggccga tctgttcaga 2609281 ggtcagcttt aatacaccgt acaagttttt tgacagcgga taatcgcttg ttgtgatttc 2609341 ccgtcctaag agcgagcgcc cgtctttttc atatacatct gtgacatgat tgctgctggc 2609401 gaacacgagc ttttgaatgc cgagctccgc tgccgcacgg cacagataat agcttgccct 2609461 atagaaaaca tccgtcattt tttcaaactc agcgatgtcc ataatatcgt atttgatttt 2609521 cacagcgagt aaattcaaga tggcatcggt atcttttgga atcttcttca acagctcctc 2609581 ataatttgcc gcgtcagcct gaatggaaga ggctttgcca tcgaaatgat ctttatcaag 2609641 cacagtcact tcatagtctg aaataagccc ttcagcaagc agtctcccaa tcacaccatt 2609701 tccgccggcg atcagcactt ttttcacgat gttcactccc cttttttata gattgcccat 2609761 tttcggcggg gctgacactt ttttggcact cacattctta ggcttattca aaagtcaccg 2609821 gcagctcctc aagcgcccga aatccaaaaa gcggccgata ccgccattca aaatccgcaa 2609881 gattaaggct gggcattcgc tgcagaagag tgttaatcgc aatttgcgct tctaatcgtg 2609941 ccagcgagga ccctaagcaa acatgatggc catgcccgaa tgaaagatgc ggattaggac 2610001 ttctcgtaat atcgaagaca tcggggttcg tgaatatgct agggtctcga ttagccgctc 2610061 ctaacaaaag atagacttgt tctccttgac ggatcgtcac cccgcagatg tcaatatcct 2610121 ctgacgcaac tctggctgtc atttgcgtgg ggctttcata gcgtaaacat tcctcgactg 2610181 cggtaccaat aagatctgga ttttctctca gtttcaaaag ctgttctgga tgctgcagca 2610241 gacaaaggac tgaattgctg atgagattga ccgttgtctc atgtccggcg atcgccagca 2610301 atatgcacgt agatgccgcc tcctcttccg tcagcttatc cttttctctc cccttcaaga 2610361 gcatgctgat catatcctgt tgagggtggc gttttctctt ttgaatcagc tctttgaaat 2610421 atgccatagc ctgcacagcc ataatattgc cctctgttaa tgcctttctt gagcgggtaa 2610481 aatcaatcgt ttgaatgaga ctcgcagccc actcctttaa ttgctcccta tcttcctccg 2610541 gtacacctat aatgttagct atgacaaaac ttgctaaagg aaaagcaaag tccgaaatga 2610601 cctccatctt ttttttacct tgcacttgat caagcaaatg atggacagtt tcaatgatat 2610661 acggctgata actctctgtc gttctcggcg taaacgctcc gctggcaagc gtccgcaatc 2610721 gtctatgatc aggctggttc tgaaacagca tcatttgatt ttgcacatgt gaaaggtcct 2610781 gatatttggt tgagctctca ggcagcgggg tgcggacttt gaatctcgca tctttcaaaa 2610841 tagcagccgt ttcttcatat cctgtgacat accagcccgg gtattttaag aaactccctt 2610901 tatagatagg atgaacagct cgcaatgtgt cgtaaaaaga atatgggttt ttcaaaaact 2610961 cagaagatgc agttgacgat gcaattgtca cgtgattttc tcctttctgt tcaaaaataa 2611021 aaacaatcga catcataccg attgctttta ttgattcttt cagcttttcg cacttaaact 2611081 agccttcatt tcttcgactg attcaacttc aaagcctaaa tcactcagca ttttatgatc 2611141 ctccgtctcc tcttgcccgg cagttgttaa gtagtctccg acaaaaatgg agtttgcggc 2611201 gtaaagccct aatggctgca atgtgcggag attgacctct cttcctccgg aaatgcgaat 2611261 ttcttttgat ggattgataa aacggaacag cgccagcact tttaaacaat acagcgggtt 2611321 taattcgttg acgccttcta acggcgtgcc atcaattgca tgcaaaaaat tcacaggaat 2611381 ggaatccgcg tcaagagcct tcaagctttt ggcgatgtca atgacatcct gtttcgtctc 2611441 cttcatcccg ataatggcgc ctgaacacgg agacagcccc gattcttttg cgatttcaac 2611501 cgtattgact ctgtcatcgt atgtatgtga ggttgtgatg tttgaatggt ttctctgtga 2611561 cgtattcaaa ttatgattat agcggtctac tcctgcatct ttgagccgct tcgcctgctc 2611621 tggcttcaac agtccaagac atgcacaaat cttcagtcca tacgtctctt taatttcctg 2611681 aaccgcatct acgacctgat ccacttctct gttagacgga cctctgccgc ttgccacgat 2611741 acaatatgtg ccgatattca gatcgtgcgc ccgcttcgcg ccttcaagca gcgtttcctt 2611801 attcaccatc cggtaagact caatcggcgc tttcgaaatc gcagactgtg aacaatagcc 2611861 gcagttttcc gggcagagcc cggatttcgc attcataatc atattgagct ttactttttt 2611921 tccgtaaaag tgttttctga tgtgaaaagc cccgtgcatt aatagcaaaa tatcttcatc 2611981 aggacaatgt aatattgaaa gcgcctcttc gtcagtcact tctgctccag ccagcacccg 2612041 gtctgcgagt tccatccatt gattcattct cataccccca cttgattcat cagtaatgat 2612101 agattgatat ggtcttttac catatgtaga accgtttctt tcgtcacgtt ggcaagcttt 2612161 ggcgtaaccc ctaaaatcgg cacaccgcat aagcgctcaa tcatctcagg attggttttt 2612221 tcatcttcat caggagagtc actgattcca ttgatgataa ttccggcgat tggaagcccc 2612281 atgctttctg catatttgac agttaaaaag gtatgattaa tggttccaag gcgaggacgc 2612341 gccacaataa tcatgggaag ctgcaacgct tttatgacat gactgaccaa atagtcctct 2612401 cccaatggca cagaaatacc gcctgcacct tctacgatga agcattcatg tttttctcta 2612461 atccgccccc aatggcttaa aacctcttcc atggtgacag tctttccctc aagtttccct 2612521 gcaacgtatg gtgcaagcgg cgccttgaag gcaaaaggcg taatgtcttc atgagaaaga 2612581 ctggtctgcg acatatcttt cagcaaactt gtatcactat ctggatgatg gcgcgatatc 2612641 ccgcttaaaa atggtttata caccccgaca tgtctattat tgtctttcaa taaggcagca 2612701 agaccgctgg atataaccgt tttccctact tctgtatcag ttcccgtcac aaaaaaaccc 2612761 ctcaaatgat gtgcagctcc tttccgattg aatgaaatgt ttgcagcaaa tgatcaatat 2612821 cacccatact gtggtcagac gtgattgtaa ttcgaatccg gctttcaccc ggcgcaacgg 2612881 ttggcggccg aatggcagga gcataaattc ccttgccctg cagtttttca gcaaatagga 2612941 ccgttttatg ggcatcgcca atgactacag gaataatcgg tgtgtgatct cctttcacca 2613001 cataacccat attcttcaga ctggttctga tcatgctgat ataagaaaat aaaagctgtc 2613061 gtttttccct gctggcttca atgatgttga aagcctcgtg agcagccgca cagctggctg 2613121 gcggaatagc ggtttgaaag ataaatgttc tggcatggtt cagcaaaaag tcgatgaaga 2613181 ccgctgatcc tgccgcaaaa cctccttccg cgccaacagc tttgcttaag gtgccgataa 2613241 caatgtcggg acaaacacca aagtattcac tcgttccttg tcccgaatcg cccaaaactc 2613301 ctgttgcgtg ggcatcatca acgaccacga aggcatgata gcgtttcgca agtgagatga 2613361 tctgatcaag aggggcgatt gtgccatcca tgctgaatac tccgtctgtt acgataaaac 2613421 ggcgctgata acgctgtgtt tcattcagct tgttttcaag atcattcata tcaatatgcc 2613481 gataaacaac tgtatcagcc ttagaaagtc ggcagccgtc gatcatactt gcatgattga 2613541 gctggtcact taaaatgaca tcttcctttt ctggcaagga tgaaaggaca ccgacattgg 2613601 ccaagtaacc gctcgaaaac agcagggccg cttctgtcag tttaaagctg gcaatcttct 2613661 tttctagctt ttcatgccag accgaattgc ctgtcgttaa acgtgaaccg ctgcttcctg 2613721 tcccaaattg ctgcaatgct gtttgggctg catcgatcaa acgtctatcg cttgcgagcc 2613781 ctaaataatt gtttgaggac cagaccgttt gattttcgcc atcaatattc ctctctggaa 2613841 ccggcgctcc atccattgac cgcaggttac gatgtacgcc ggcttctttc attctgtcta 2613901 accgctcgtt taaccaggaa tcaatcttca aggctcgtaa cctcgtggat cgcttgtttc 2613961 ataatggcaa ccatttccga gagctcttca gctgtgctgg caagaggagg aagaaatgca 2614021 atcacgtccc caagcggtct tgtcagcatt cctaactctc tcatttttaa ggaaactttg 2614081 tatccaatcc gccgatcagc cgggtaaggt tctttagttt cctttgatcg tacaagctct 2614141 gcaccgcaca taaagccaag ctgccgaata tccccaacat gaggaagagc gtgcagatct 2614201 tgaagaagaa aatggagctt tttacttttt tccgctactt gttccacaat gttttcagat 2614261 tcaaataatg ccagattttc aagcgcaacc gcacagccaa gctgattgcc tgtataggaa 2614321 tggccatgga aaaaggtttt taggttttca taatcatcat agaatgcctt atagatgtct 2614381 tcagtggcaa acgtaacggc aattggcaaa tagcctcctg taatgccttt accggcagcc 2614441 atcagatcag gctggacatt ctcgtgctcg cacgcaaaca tttttcctgt acggccaaag 2614501 cctgtagcga cttcatcaac gatcattaag acatcgtatg ttgtacatag ctcgcgcacg 2614561 cctgccaaat atccttccgg catcacgatc ataccggacg cgccttgtac cattgattca 2614621 atggaaagcg cggcaatttc ctcatgatgt tcctcaagca gctgtgcaag ctctcggagg 2614681 cactgatcac ggcactcatc aggatcaccg ctttcagaac gatacacata aggaatcggg 2614741 gccttgtaac tctcgaacat caacgggccg tatacgtggt gaaaaagctc aattgaaccg 2614801 acactgacgg cgccaatcgt atcaccgtga tacccgtttt tcattgcgat gaatttttgt 2614861 ttctcgggct tcccgatgtt cttccaatac tgaaacgcca tttttagggc tatttccatc 2614921 gcctctgcgc cgctgtctga ataaaagacc cgcgtgagct tttttgggct gatgtcgatt 2614981 aatgtttcgg caagctgggt tgctggaaca ttggtcatgc ccaataacgt ggagtgcgca 2615041 atttttccga gctgtttttt tatggcgtca tctagttctt ttttgcggtg tccgtggaca 2615101 ttaagccaaa ccgatgaaaa accgtcatag tattccttgc cgtttatgtc tttgactttg 2615161 attccagtcc cgctttcgat gattaagggg ttttcatcat aatctttcat ttgggtaaat 2615221 ggcagccaga ggtgcttttt acttttttct atcaaatcat gagtcatgat cttcctccca 2615281 ctctattaaa ataggctgct tctccaggtc atgtatgtac gtgtttacat cattggatcc 2615341 atcaataaaa aagactcggc agccctcttc agtcccgtat tctttcattg ctgtaatacg 2615401 ctgatagccc attttcttac ccgcaacata gcctgttatg taatccggat cgtccgacca 2615461 gcataattct gcaacgactg ccgggtgccg gcttaccttt gaagcgagcg caagggcctc 2615521 ttttattctt gaatgagctg gcacgtgact gtgaagcgcc catttttcaa aattagcgtc 2615581 cggccaatcc attctggaga cccgcacccc tttttctttt gtttgatcca ttcgcttgcc 2615641 tgtatgaata tcaaacaaca ccgcacccct gacatctgac cattcaggga tttgttcata 2615701 tgctttttca atcacgtctc gtgaaacgcc ttctttttcc aataacaatc gggcaagctt 2615761 ttgtccttct tccgggcagc tcacttcatt cgtatgcaca ggcaatggct gaatggtttt 2615821 tatcgattca tgtacctctt caaattgaat ttgcataaaa tcaggttttc ctcttgaatg 2615881 ggataaccct ttttctaata aagcattgac tgtatgcttc atctcatgga aaggaataag 2615941 ccgttctccg ccggatatat gctttccgcc gtcttcatga gatccattca ttgaagccct 2616001 cattctgaca ctataaaaag tttcttcttg catcatttct cgccctttca ctgataactg 2616061 aagaacgtgt agcgcttctc acctaaattg ttaaccaatt atattcaaag gttaacaatt 2616121 agaatatatt attctctcct gtttctgtca atagaagaaa ggatcgattt atggcagttg 2616181 gttaaaagga aacaaaaaga ccgttttcac acaaaacggt ctttttcgat ttctttttac 2616241 agtcacagcc acttttgcaa aaaccggaca gcttcatgcc ttataactgc tgtttcgaaa 2616301 tgtcccgaag cagaacggac cactcggtag caatcagcag ctccctgtcc agcatagaca 2616361 gctgtcaatt ctttttcgat tttgtccacg ccctcagccg gcgttaaccg atcgtgtaca 2616421 ccaacaagac taaggtgcgg gcgcggcgcg atcaggcttt ggatctccga tgcggaaaaa 2616481 tgctttgcaa gcgatgggac gtaataataa aagccgtgcc tgtcaagatt ctgtgttttg 2616541 atcagcacgt gatgatccac ctggctgcac aaatccacac acaccttaat ccggtcatcg 2616601 agcgccgctg tccaccacgc catcaaacct cccatagaca tgccgatggt tccgatcctg 2616661 tcaggctgaa catcagagcg tgactgcata tagtctaacg cacttaaact gtcataaatc 2616721 atcatccccc acatcacttt tccggtgaga agcatttctt taaatatctc gctttccgct 2616781 tttccccgcc gatctccaaa cccccaatga tcaatcgcaa gaacgccgta tccgagtgaa 2616841 gtaagctcat cagaaaaaga aggcgttttc aaataatccg ctccctcaat cagctcactt 2616901 tttcccctat catactggcc tccatgcgaa tgctgaaaca atacggctgg gcacggtcct 2616961 tctgttttct tcggcttcac aaaataagcg ggcgcctttt catgtccatt taaatcgagc 2617021 aggagcgttt caacgatatt ttcttctctt tcttcaatac gtaatgtctc aacactgatt 2617081 ggcctccgat caggcaaatc accaagcaat cgaaacagtt gctttcttct ttcggctctc 2617141 atcccatcac ccttccttat tcgcttactt cacatttacg agacagatct gggttcccct 2617201 ttatttttcc aacataaatc acatcattta ctaaatattt agtaaatatt atggaatatt 2617261 tcgaaaacaa ttattgtaac cgcttacttt tatatgataa tatcaattta tcaaaaacag 2617321 atgagttaat attttactaa atagatgaga gggataccca tggttcgtat taaagatatc 2617381 gccttgaaag ctaaagtttc cagcgcaact gtgtccagaa ttttaaatga agatgagtcg 2617441 ctttctgttg cgggcgaaac gagacaaaga gtcatcaaca tcgctgaaga gcttggttat 2617501 caaaccgttg ccaaacgccg aaaatcccgc gggcaaaaac agcgggctca gccgctgatc 2617561 ggtgtgctga gctgtctgtc ccctgatcag gaaaggcagg acccttattt ttcttccatt 2617621 cggaaaggga ttgaaaagga atgctttgaa caggaaattt tcattacaaa ttcgattcat 2617681 ctcggctcct ttcaggaaca tatctttcgg gaattggatg gtgtcattgt catcggccgt 2617741 gttcatgatg aagcggttaa gcatatcagc gggaggctgg agcatgccgt atttatcaat 2617801 cattcaccag atccgcaagc atacgattcg attggcatcg attttgaatc ggcttcacgc 2617861 caggcgattg atcacctttt cgacttaggc tacaaacggt taggctacat tggcggacaa 2617921 gaaaaagagc atacgctgaa ggacggccaa agcattcgca gaacgattga agataaacgc 2617981 ctgaccgctt ttttggagtc agccgccccc cagcctgagc atgtgctgat cggagaatac 2618041 agcatgcgtg agggctatcg cctgatgaag aaagcaatcg atcaaggcca tctgccggaa 2618101 gcattcttta ttgccagcga ttctatggcg atcggcgcat taaaagcgct gcaggaagcc 2618161 ggactgcaag tgccgcggga taccgcaatc gtcagcttta acggcattga ggaagctgaa 2618221 tttgccagca cgcctttaac gacggtgaag gtatacacag aggaaatggg ccggacaggc 2618281 gtaaaactgc tgcttgaccg tctcaatggc cgaacgcttc ctcaacatgt caccctgcct 2618341 acaacattaa tcgtaagaca aagctgcgga tgtacagcaa aggaggtgac ataagcaaag 2618401 attcatcacg atgataagga ggaaaagatg aaacacactt ttgttttatt tctctctctt 2618461 attctgcttg ttctgcccgg gtgttcagca gagaaaagct cagcagatac cgcaaaaaag 2618521 acgttaacca tttattctac aatgtcaacc gacagtgaaa gagatacgtt cagaaaacta 2618581 gcggcagcat tcgaaaagga acacagtgac attcatgtca gccttcattt cccaggcaat 2618641 gactatgaaa atatgatgcg tgtcagaatg gcggccaatg atttgccaga tctattcgat 2618701 acacatggct gggggaaaat caggtacgga gaatatacag cggatctccg ggatatgaaa 2618761 tggactcaag atcttgatcc caatttaaac agcatcctca aaaataaaag cggaaaggtg 2618821 tatgcctatc caatcaatca ggcaaaagac ggtctggcgt ataatcgcaa tattttagac 2618881 cgttacggca ttgctccgcc ggaaaccatg gatgacttta tcaaagcact gagaacgatt 2618941 aaagaaaaga gcaagggaag cattgttccc ttctggtttg ccggatatga caaaagctca 2619001 ttcgcccaat attacgacca attcgctaca cctcttctca tcacagaccc tgcccataat 2619061 gaaaaaaaac agctcatcaa cggcactttt caatggagta aattcactta tttatcagaa 2619121 atcctcaaac aaatgcagaa agaaaaattg atcaatatcg acgccgtcac ggcaaaaaaa 2619181 tcacagctca ttgaattaat ggcccaaaac aaaatcgcct ttacaatgca aggcggcaca 2619241 ctcggccaag acgttgccca gatcaacccg aacgtcaagg tcggcattat cccgacacct 2619301 gccatccatc ccggtgatga cccgatatgg atcggcggtg aacgctacac ccttgcagca 2619361 tggaaagatt cgcctcaatt aaaagaggca aaagatttta tcgcatttat ggcccgcccg 2619421 gccaatgcca aacaaatggc tgaagccaca tcgcttcctt cagggctgac caatgtgaaa 2619481 gctgatattt tctacgcaaa cgattatgag tattatcaag atgtcaaagt cgagccttac 2619541 ttcgaccggt tatacttgcc aaacggaatg tgggatgtcc tgggcacggt tgggcaggag 2619601 ctcgcggctg acattttggc gcctcaagac atttcgcaga agctgggaag agaatataaa 2619661 cgactccggg agcaatccga aacacaggga gctgaaaaca atgagtgaga tcgcaaggga 2619721 cgttcatgtg aaacaggtta agccaaaaaa gcagtcctca ctttggtgga tgtacattcc 2619781 tgctttgctc tccgttctgg tctttatgat ttacccgttt gtgaaaggca cattgattac 2619841 ctttacaaac tggaacggat tttcacaagt ctaccaatgg gttggattcg cgcaatatga 2619901 aaggctgttt tctgatcctg atacttggca tatcttaaaa aacacgctgc attacgggct 2619961 tggcagcacc ttttttcaaa atgtggtcgg gcttctgtac gctctcctct taaatcaaag 2620021 cattaaaacg aaagcggtaa caagaacaat tgtgtatttg ccggtgatga tcagcccgct 2620081 cattatgggc tacatttggt actttttctt ctcctatgac ggaggcgcgc tcaacgattt 2620141 gctcggggtc ttcggcatca gccctattaa tgcgctcgcc agtccctcgc tcaatccatg 2620201 gatcattgtc atgattaaca cctatcaata tgtcgggatc gctatggttg tctacttagc 2620261 cggtctgcaa agcattccga aagactacta tgaagcggcg caaatggatg gcgcgaaaca 2620321 aggccagcag ttttttacca tcacgctgcc gctgttaatg ccctccatta ccattaatat 2620381 agtcatcaac attatcggag gcttaaagct gtttgacgtc atcattgcac tcaccgcagg 2620441 cggccccgga aatgcgtcac aatccatgtc cacgtttatg tatgatttgt atttcaaacg 2620501 gcaggatgcc ggctatgccg caacgcaagg catatttatg gcatttgtca ttttgatcat 2620561 cagcttttgc gcgcttgcgt actttaaaag aaaggagacg gaaatgtcat gagagccgcc 2620621 cgtacaaaaa gcatgcggat cattacgctt cttgcagcca ttgtggcctg tgcgcatttt 2620681 attccttttt atatcctgct gaccacttca ttgaaagcaa aaggagacta cagttcgaaa 2620741 tggatatttc cagccgacat ctcctttcat aatttttcag aggcgtggga gcgcgcttcg 2620801 ctaggaaact cttttataaa caccatgatc atcacaggtt tttctgcctt gttattaatt 2620861 atattcggct cacttgccgc ctacccgctt gcccggcggg aaacgaaact gaataaagcc 2620921 gtttttgcct tgctgatttc cattatgatc atccctccgt taacgtccat ggttcctttg 2620981 taccgaatgg tcgtggacgc cggaatggtc aatacacacg caatcgccat tttcatcaat 2621041 acagcggctt acatgccgtt aaccgtattc ttatattcag gctttatccg atcgaccatt 2621101 ccaaaagagc ttgtagaagc cgcaagaatt gacggtgcag gcatgctgaa aatctttttt 2621161 acgattgtgt ttcctctgct gaagccgatc actgcgacca tctgtatcat ttcttgtgtc 2621221 tttatttgga acgactatca atttgccatt ttctttttac aagatcaaaa ggttcagaca 2621281 ttaacagtag ccatggcagg ttttttcgga gaaaacgcaa acaaccttca tttagttgcc 2621341 gcagcggcac ttatggcaat gctgccgatg gttgttctgt ttttggcgct gcaaaaatac 2621401 tttattgccg gcctgtcttc cggagcggta aagggttaac attaaagggg gaagcaatat 2621461 gaaaaagatt acatttatcg gtgcagggag cacgattttc gccaaaaatg ttttgggaga 2621521 ctgcctgtta acagaggcac tgaatggatt tgagttcgct ctttacgaca ttgatcccaa 2621581 acgcctgcag gaatcccagc tcatgctcga aaatctaaga gaccgttata acccaagtgt 2621641 ggccatcaac agctatgatg acagaaaact cgccttgcaa aacgcaggct atgtcatcaa 2621701 tgcgattcag gttggaggat acaaaccgag cacagtcatc gatttcgaga ttcctaaacg 2621761 gtatgggctg cgccagacga tcgccgatac agtaggcatc ggcgggatat tcagatctct 2621821 cagaacaatc ccggtcttat ttgatatcgc aaaagatatg gaggaaatgt gccctgacgc 2621881 atggttctta aactatacaa atccaatggc cactcttaca ggcgccatgc tccgctatac 2621941 caatatcaaa acaatcgggc tctgccacag tgttcaagtg tgcacgaagg atttatttaa 2622001 agctctcgga atggagcatg acggaattga ggaacgcatt gcgggcatta atcatatggc 2622061 ttggcttttg gaagtcaaaa aagacggcac agatttatat ccagaaatca aaaggagagc 2622121 gaaagaaaaa caaaaaacaa agcatcatga tatggtgcgg tttgaattaa tggataagtt 2622181 cggctattat gtcacggaat cgtccgaaca taacgcagag tatcacccgt actttattaa 2622241 acggaattac cctgaactga tcagcgagct gcaaatcccg ctcgacgaat atccgagaag 2622301 gtgcgtcaag cagattgaaa attgggagaa aatgcgggat gatatcgtca ataataaaaa 2622361 ccttacgcac gaacgctcaa aggaatatgg ttcaagaatt atagaagcaa tggaaacaaa 2622421 cgaaccattc accttcggag gaaacgtctt gaatacaggg ctgatcacca accttccttc 2622481 aaaagcggtt gtggaagtga catgcgtcgc cgacagaaaa aaaattacac cgtgcttcgc 2622541 cggagaactg cctgagcagc ttgcagcctt aaaccggacg aatattaata cacagctgat 2622601 gacaatcgaa gcggctgtca cacgaaaaaa agaagcggtt taccaagctg caatgcttga 2622661 tccgcataca agcgcggagc tttccatgaa ggacatcatc tccatgtgcg acgatttatt 2622721 tgcagcacac ggcgattggc ttccggaata caaataaaaa ctaggggacc gctctcccct 2622781 agttttttgg ttttgtttcg ccttcccagg ccatcatgcc gccttcaaca ttgactgttt 2622841 taaagccttg ctcatccagg tacttgcaga cgttcatgct gcgcattcct gagcggcaga 2622901 taaatacgta ctctttgtct ttatcaaggg tttccatttt ttcaggaata tcccccatgc 2622961 gaatatgaac ggcttgcggg atcatgcctt ccgctacctc ttcatcttct ctgacatcaa 2623021 ttaaatataa ttcttcgtcc gcctcaattt tttctttcaa agcggctgtg ctgatttctt 2623081 ttatttccaa agaaaacact cctattcaca gtgatcatgt tcagtatatc aaagtcagcc 2623141 gaacgattgc tattctgaga ctgatgaaaa aaaatcccct tttggcaaag gggatttttt 2623201 ctaggcttag tttgccacaa tattgacaag cttcccaggc accgcgatga ttttccgaat 2623261 cgttttgcct tcaagctgct ctttgacctt ttcatctgct tgagcaagct gttccagctg 2623321 ttctttcgtt gcatcggcag gaacctgtaa tttcgctttt acttttccgt tcagctgaac 2623381 aacgatttca acttcatcat ccacaagttt tgtttcatca tatacaggcc aagcttcgta 2623441 ggcaattgtg ccggaatggc caagcttctc ccatagctct tccgctaagt gtggcgcgac 2623501 aggagaaaga agcttcacga agccttccat atattctttc ggcagttctg ttgctttata 2623561 agcttcatta ataaagacca tcagctggga aatacccgtg ttgaaacgaa ggccttcata 2623621 atggtctgtg actttcatga ccgtttcatg atagacgcgc tccaatgttt cacccgcgcc 2623681 ttcaacgatt tttccattaa gctcaccgct gtcttcaata aataggcgcc atacacggtc 2623741 aaggaaacgg cgcgcaccgt ctaatcctga ttcagaccag gcgattgaag catcaagagg 2623801 tcccatgaac atttcgtaca atctcagcgt atcagcaccg tgagaggcca cgatttcgtc 2623861 aggattgaca acgttccctt tagatttact cattttttcg ttgttttcgc cgagaatcat 2623921 tccttggttg tacagctttt ggaacggttc tttcgtcggc actacgccga tatcataaag 2623981 gaacttatgc cagaagcggg catacagaag gtgaagcacg gcatgttctg caccgccgat 2624041 atacatatcg accggaagcc atttttccaa tttttctggt gatgccagct gatccggatt 2624101 gtgcggatca atatagcgca agaaatacca gcagcttccc gcccattgcg gcattgtatt 2624161 cgtttctctt cttccttttt tccctgtctc agggtctgtg acttccaccc actctttaat 2624221 gttcgcaagc ggtgattcgc ccgttccgct cggtttgatt tcatccgttt ttggcaaaat 2624281 cagcggcagc tcctcttccg ggacagctgt tgacgttccg tcttcccaat gaatgaccgg 2624341 aatcggctcg ccccaataac gctggcggct gaagagccag tcacgaagac ggtacgtcac 2624401 tttcttctca ccgtttttcg tttcttccag ccaagcgatc actttttcaa tcgcttcctg 2624461 tttgtgaagg ccgttcagga aatcagagtt cacgtgctcg ccgtcgccag tataggctgc 2624521 ttcctcaacg ttcccgcctt ttacgacttc cttcaccgga aggccgaatg ttttggcgaa 2624581 ttcaaaatca cgctcatcgt gtcctggaac tgccatgaca gcacctgttc cgtatgatgc 2624641 aagaacataa tccgcaatcc aaatcggcag tttttctccg tttacaggat tgatcgcata 2624701 cgctcctgta aatacgcctg tctttgtttt cgcaagatct gtgcgttcta ggtcactctt 2624761 tgattgaatt tctttgatat aagcttcaac agcttctttt tgctctgccg ttgtgatgtt 2624821 ttccaccaat gcgtgttccg gggcaaggac agtgtatgta gcgccaaaca gcgtatctgg 2624881 tcttgttgta aacactgtaa aggaatcatc atgtccatct atagcaaaat gaacgtgagc 2624941 gccttccgaa cggccgatcc agttgcgctg catatcttta atgctttccg gccaatcaag 2625001 ctcttccaag tcctcaagga gcctgtccgc ataagcggtg attttcagca tccactgctt 2625061 cattgggcgt ctctctaccg gatggccgcc gcgttcgctc ttgccgtcaa tgacttcttc 2625121 gttggcaaga acagtaccga gcgcagggca ccagtttaca ggcacttcgt caacgtaagc 2625181 aaggcctttt tcgtatagct ttaagaaaat ccattgcgtc catttatagt attcagggtc 2625241 agtcgtattg atttcgcgat cccagtcata tgagaagcca agcgcttgaa tttggcggcg 2625301 gaagttatca atattctgct tcgtaaacac agcggggtcg ttccctgtgt caagcgcgta 2625361 ctgttcagct ggcaggccga atgcgtccca gcccattgga tgaaggacat catagccctg 2625421 catgcgcttc atgcgggaca gaatatccgt agctgtgtat ccttcaggat ggccgacgtg 2625481 caacccagct ccagacggat aaggaaacat gtccagcgcg taaaattttt gtttttcatt 2625541 attatcaaga gtggcaaatg ttttgttttc aagccaatat gtctgccatt tcttttctat 2625601 ctctttgtgc tgaaaactca aagtaaaaac ctccttctga ttgaatacgg cgtgtatggt 2625661 tcaagtattg acgggaagga gaggattata ttcagaatat tcccaaacta aaaaaaactc 2625721 cctcatccca aaaagggacg agagactttc gttttcccgc ggtaccaccc tcgttagcgc 2625781 ggcatacgcc gcactcactt gatactttta acgcagttat gcgtcagcgg cttttcaccg 2625841 ctgcaactct gaggtgagtt cggaaacaaa cttgattgac tttcaccagc cgtcaactct 2625901 ctgcaacaat atctgtttct tactgctcct cttcattgtt cttatcgcaa ccgtaatcta 2625961 actgtatttt atagaattct gttcataagt gcaagcaggt ttgtatacaa tgggaatgta 2626021 ccctgaacgg gcggagattg aggacaatta ttcgggtgga gttttggttt gacgtttgga 2626081 ctcggccggt tcgccgccgc tgttcagttc tctcacaaag tcaaaacttc tgagaacagc 2626141 ttcaccgccg tagcctgaga taatggataa gatgacaagt tgaattcctg aatcggggtc 2626201 agcggataat acaagtaaaa tggaagccgt catgccgata aaccaatctt ccaaaaatcc 2626261 aaggtagata aaccgcttcg tcattctggg cttctccagc ctgcctctct ttttcacatg 2626321 accgagaatc cccatgattc ctccaattac acaagcaatg agtacctgat gcagcatctt 2626381 catcatcacc ttcctaaagc ccttatttcg taaagcgact tcaggccatc cagccccctt 2626441 aaacgattcc gatgattttc gatatctaca taccggcaaa tctgtaaaaa gcttgtttct 2626501 tccattatat gtgaacacat gatcggtaag cttgatgcat tggattcatt tttcacccag 2626561 tgacattgac ctagtcacct atttagcatg tagaaaacct ttccgttcat atgttcaaat 2626621 tctgttctta tttttagtgt atacgaggac aagccctaat gacaaacaac aaactgcact 2626681 tgcttgaatc agaacatgtg ttgtgctacg gttactgtag aattcatttt taaaaagggg 2626741 aatatcaggc tttcgcatag caagctgacg gcctaagggg gatttatatg gctagttttc 2626801 aatcatttgg gataccagga cagctggaag tcatcaaaaa agcacttgat cacgtgcgag 2626861 tcggtgtggt aattacagat cccgcacttg aagataatcc tattgtctac gtaaatcaag 2626921 gctttgttca aatgaccggc tacgagaccg aggaaatttt aggaaagaac tgtcgcttct 2626981 tacaggggaa acacacagat cctgcagaag tggacaacat cagaaccgct ttacaaaata 2627041 aagaaccggt caccgttcag atccaaaact acaaaaaaga cggaacgatg ttctggaatg 2627101 aattaaatat tgatccaatg gaaatagagg ataaaacgta ttttgtcgga attcagaatg 2627161 atatcaccaa gcaaaaagaa tatgaaaagc ttctcgagga ttccctcacg gaaattactg 2627221 cactttcaac tcctattgtc ccgattcgca atggcatttc ggctcttccg ctagtcggaa 2627281 acctgacaga ggagcgattt aattccatcg tttgcacatt gacgaatatc ttatcaacat 2627341 ccaaagatga ttatttgatc attgatttat ccggattggc ccaagtgaac gaacaaacgg 2627401 ccgaccaaat tttcaagctg agccatttgc tgaaattgac cggaactgag ttaatcatta 2627461 ctggcattaa gcctgaattg gctatgaaaa tgaataaact ggatgccaat ttttcgtcgc 2627521 tgaaaacata ttcaaatgta aaggatgccg ttaaagtgct tccgattatg taaaaagatc 2627581 ccgctcaccc agctggatct ttcagattgt tgacaaaatc ctaaaatggt tttcatttta 2627641 ggattttgtc atcttttcag cgtgattgaa aacccttgaa gtctaggaag gacgagcata 2627701 ggagcggagc gaatgttcta attcgtgagc accgaagcgc aggcctgaca acgaatgcga 2627761 gggtttgtcg acacgctgaa agatcccgct cattcggcgg gatcttttat tatgaagaga 2627821 ttgatgcctg cttatttgtt tctttagctg attttatccg tttgtcatat agaagcgttg 2627881 tggcaatact gatcagcagc aataccaaca gagataaaac aagagcccta atgccgtaat 2627941 gatcgacaag cactcctccg aacaggggac caatcattct gccgcctgtc gccgcactgt 2628001 tgacaaagcc ttgataaaag ccttctttcc ctttaggggc aagctgattg gcaatagtcg 2628061 gcacagcagg ccaaacaagc atttctccga tagtcaggat caccatcgca gcgagaaaca 2628121 tcggaaattg ctttgcagtc agcagcatgc tgaaagacac aataaaaatg ataaagccga 2628181 tgaccatttg cgcttttagc gactcggccc attttttcac cacaaaactg acgagcggct 2628241 ggccgagcac aatgagaatt ccgttaaccg tccacagcac gctgtataag gaaagagata 2628301 ttccaatgct ttgtgtgtac gaagcaattg tggttgacca ctgagaataa gccagccatc 2628361 cgagtacata gcctccgctt aaaatgatca gtgcggcaaa ttttgctttg ctgttcacag 2628421 catcataatc aagcacggat gtttgggatg catcgcccgt ttgaatattt cgaaatccga 2628481 aatatacaat aaagaaaaag atcagataca atacggcatt tgccaaaaat acatatgaaa 2628541 acgagaaaga tgccacgaca ccgccaagcg ctgaaccaac ggccacgccc gcgttttgcg 2628601 cgacatatat cgcattaaat gccttccttc ccccttcagg ccataccgat cccgccattg 2628661 cgtagcttgc cggaaaaaca acaccggagc caaagcccac aatcgtcagc agcacaatat 2628721 aggctggcca atcatgaaaa aagacaagac ccatcaggct tgctaacgta atggctatcc 2628781 caagcataat cgatttaaaa ccgccgattt tatcaaacaa aaaacctccg cataaattgc 2628841 cagccacact ggcgccggaa ttcagcatca ggacaagtcc ggctactgtt aacgactttc 2628901 ctaaatgatt atggatataa atcgtattca gcggccataa aaaagaagca cccgtcacat 2628961 tgataaacat tccaatgact aaaattttaa gagcacgcgg catactcatc cccctttctt 2629021 acctaaaaaa gctcatgaaa aaaacgaaac ctaaaacggc tccgtacgaa tccagttatc 2629081 atagcacatt cattctatct gtctctctca catttttcaa ctgatgagcg tgaaaaaatc 2629141 taacaaatat tgtttgaaaa atgtaaaata aatagaaaaa ggggtcatat tatggaaatg 2629201 gtattagcat tcttaggttt tctggcatgt ctcattgcac tgggctatgg attatatcac 2629261 cttgtcagat atgtactgaa aaaggaaaaa cgtttctcaa agagactttt ttggccgctt 2629321 ttcattggag gccttgtgct gctctttacc ggggcagcat tggcagaacc tgacactgcc 2629381 gcagcaaatg ccgagaaaaa atattcagcg ctaaacgccg aatataaaaa cctcacaaaa 2629441 gagcacgaag aacttgagaa agaatataaa tctgtcagct ctgaagcaaa gaaattaaaa 2629501 gacaacaaag aagatcaaga caagcttgag aagcttaaaa acgaaaatag cgatctaaaa 2629561 aagactcaga aatcattaaa agctgagatt aaagagcttc aagaaaatca aaagcagctc 2629621 aaagaagatg caaaaacggc aaaggctgaa aatgaaacac ttcgacaaga taaaacaaag 2629681 cttgaaaatc aattaaaaga gacggaaagc caaaccgcca gctctcatga agacactgga 2629741 agttcttcaa acaatacgag taaaagtgat gaaaccaaaa cagctgacaa agcagaaggc 2629801 tgtaatatca aaggaagcag aaacggcatc taccacacgc caggcagtac atactacgac 2629861 cggacaaccg atccggctga aatgttttgc tcagttgaag aagctgaagc cgccggttat 2629921 cgggcgccaa aacgataaac aaaaagctcc agaatgtctg gagctttttc tgtttcacaa 2629981 cgacgattta atgaccttct tataataaag aactgacaga aaaccaaaaa tggagtagag 2630041 cgcagtatat aacaccatca ccataatcat aggcgcccat acctctgatc cgaataagaa 2630101 ccagccggat tggacggcaa agtaactgtg gaagaggccg acaacgagcg gaatgccgaa 2630161 gttgtacatt tgtttgatgc gtatcccctt tatcaggtcg ccctgcgtaa agccgagttt 2630221 tcttaaaatt gtatagctcg gtttttcatc ttcactttca cccatttgtt taaaataaag 2630281 gatacaacct gatgtaatca ggaacgttaa ccctaagaag ccgacgatga acatcaccat 2630341 accaaacagt gatttttgcg cagcgcttgt atctagtctt gataaatgct cgtttttctt 2630401 gttcacctgt tgaaaaagct catttgcttt ttccatttga tcgtcatgtt tcacattgac 2630461 gccgataaat gtagattgcg ccagctgaat gcgggggtct ttatccttgt ccagctgttt 2630521 aaacaggctg tcatccacaa tgacagcggg catgcccccg cttgtaaacg tgtaggacac 2630581 aagaaactct tctcttaatc ctttatattt taatggctgc gtctcgtgct tgctttttac 2630641 tttaataaca ccagagtcct tgaaaaccat tattttttgc agcaagtcgg tgtatcctga 2630701 gaaaacggct tctccagccg ccacatcgac tccttttaca tctttgtcgc taacaacagc 2630761 aagctgcata ttgccgggat cgccctgcat ctctttcgga gttccatcca taatatttgc 2630821 aatgtcaaca tttgcttgca ggacaggtgt tgcctttttt acaaacgaga tgttgctttc 2630881 cctcaatttg ttttcaaata acttggcatc tttctcattc atgaatgaaa aatcagccgc 2630941 tacattttgt tcagcggtct tttccgacga gtaatacgag atgtaagcaa gagataacag 2631001 cccgatggcg agcgctgaaa cggttgtaat aatcgtcagc agcagcgcat tcgatttcat 2631061 tctgaacatg atcgaagaca gtgacagaac ctcagaaata tttaagtagc cgcccttgct 2631121 ttttcgaatg atattcgaga taaacgtaac tgatccttta taaaacaaaa acgtcccgat 2631181 aatgacgctc cccagaatga agctcatcgc aacaaacagt tcattaatgg tcttaaattt 2631241 tccgccaaac agctcagaag acacatagta tcctgtcaaa atcaacacga tgcctaaagc 2631301 gccgatcagc atttggaaaa atgatatttt cttcactttg tcttcagtgg aggacgttac 2631361 tttaaacaaa gataaaatac tctgtttttt gataaacgta taattcatga tcatgatcaa 2631421 aaggtaaatg ccgcagaaca caatgaccgt ttggaccaag gcctgctcag aaaaatgcag 2631481 tttcgcatcc gctttgacat cgacaatttt gaacagaatc atcaagacaa gcttcgatat 2631541 cgaaaacccg gccgctaccc cgatcgctaa tgaaccgaaa tacagcatga cattttctgc 2631601 acttaagatg cgaaaaattt tatgcttcgt cattccaatt aattgaaaca gcccgatttc 2631661 tttactccgt ctcttaataa aaatcgtatt ggcatataaa atgaagatcg ccactacagc 2631721 cacaagcaaa atcgaagcgg ttttaatagc cgcggctccc ttgattgaag ccttcacttc 2631781 gttaattgct ggatcatact gcagcgtgac aaaggcgaaa taaagcgcca cgctaaagat 2631841 gagcgcaaac acatacaaat agtaattccg gagattcttt ttcaaatttc gcaggatgag 2631901 ctgattaatg ttcatgctgc accccgccta acacgccttg cgttttcata atatcctgga 2631961 aaaacgtttg cctgtcctgg ccccctttat tcagctgtgt atacatttgc ccgtccttaa 2632021 taaaaatgac tctgccgcag tagctggcag cgacgggatc atgggtaacc ataataatcg 2632081 tcgcgttgcg tttttgattg agctggctca gcttatttaa tagatcggag gccgatttcg 2632141 aatcgagcgc gccggtcggt tcatcagcga aaataatgct cgggtcatga ataaacgctc 2632201 ttccagcgga tgttctctgc ttctggccgc cggaaatttc attcgggtat ttatcccgca 2632261 attcatatat tcccagttcc ttggcaactt cctcaaactt gcgattggct tccttttttg 2632321 atagtttcgt gatcgataaa ggcagaagga tattctcttt cactgtcaat gtgtctaaca 2632381 aattgtaatc ctgaaagata aagcctaaat gctgttttct aaattcagcc agctgctttt 2632441 ccttcatagc cgtcatgtca tttccattaa tatgaatggt tccgtgactg acctgatcga 2632501 ttgaggacag aacgttgagc aaagtggttt ttcccgaccc ggaagcaccc ataatactga 2632561 cgaattcgcc cttttcaatg tgaatatcga tgcccttcag cacttcctgt ttattcagct 2632621 tgtttccata actttttcga attttattcg cttctaaaat caccatttac gcagtctcct 2632681 ttatattgga taatctcatt ataaaaagga atgccgggct tttccttcga tacggcgaac 2632741 aaaaaagaaa agcatgtgac attttcgtca cacgcttatg acatgttcaa attgattccg 2632801 tattggaaag gttaatgtaa aaactgttcc cgcaccaaac tccgactcaa catcaatatg 2632861 gatcaataac ggcgccgctg ctttttttgc caagtacagc cccatgccag ttgacgcttg 2632921 atcatggtga tccgttgtgg atgtaaaccc tttatcaaaa atacgcggta catcttttgg 2632981 atcaatgccc ctgccacaat ctttcacttg gagctgcgtc tgttcccctt tttgaaagct 2633041 tttgatctcg atttcagagg cttcgctgta tttcaccgcg tttgtcagca gctgcctgat 2633101 gataaacgcc agccattttg catcgctcag cacttctttg gcctcgagct gtatgtcaaa 2633161 accgatccct ttttggatac accacgattg taaatctttg atttctttaa agatcaaagg 2633221 ctgaagctga atgaattcta ctgacaggtc gttttcaata aatgaaatgc gtttttgatg 2633281 aagctgctga tcaagaagca ggtgaatacg cagccattca tatgacagct gggatttcag 2633341 tgctttttct tccattctat caatgattaa atgcatcgct gttaatggag ttttgacctc 2633401 atggatccat gccatcagct catctttttc attttccaat gctaagcgat gccgtgctgc 2633461 ggtctgcttc aagtgttctg tttgcccggc aatgcttctt tcaaccattg cttcaaacgg 2633521 cgtttccggt tcatttatgg ctgtcacatc gagattgttc tcccatgttt tcaagctttt 2633581 ataaaacgct gtttctttcc gatagcggaa ccaaaggaat atgataaaaa acaagatgca 2633641 caaatacacc atataaagta cattcccaaa tgatatggaa ggatcgacaa aagcaatgaa 2633701 cagcatcaaa gcctgctgaa acaaaaacgc ggcaatccag ctccgccttt cgataaggaa 2633761 tgctttaatc atagaacttg tcctcttcct tcgcgatgta gccctggccc acctttgtct 2633821 cgatatatgc accaagctgc agggcgtcca gtttttttcg caggcgattg acattgacgg 2633881 tcagcgtatt atcactaaca aaacgctcat cgttccacaa gcttctgatc agctcttccc 2633941 ggctgacgat cttgtttttt tgctctatta attgttttag aatgaacatt tcatttttgg 2634001 tcagttcaac agatcctttg tcattgctga cgaggttctg ctccgcgtct acagcagcgc 2634061 cgcaccacgt tttaatcgta ctcggctccg tattataatg gtgcacacgc cggaacatcg 2634121 cttggatttt cgcgatcagc acatcaaaat gaaatggctt ttgaataaag tcatctgccc 2634181 cgagctgcat ggacatcacc atatcagcag gatgatcccg ggaggataaa aagagaatcg 2634241 gaacatttga ccgggagcgg atcagacggc accaatgaaa gccgtcaaat ttaggcagct 2634301 gcacatcaat aatgacacaa tcaggattaa ccgccgcaaa ttcctgcagc acctgactga 2634361 aatcctgaat gccgtataca tcataggacc atcccgttaa acgatccttg atttcatgaa 2634421 acagcgattc atcatcttca atcagcaaaa gtttaaacaa tcgactcacc gcactttttc 2634481 cttttttatc aagtgtatag caaaacgcca gcatgcgcta tagaaaaagc cggctgtctc 2634541 agccggctcg ttcgcattat aattctcttc tcaacgctgt cagcacgttg gttttggtag 2634601 cttttctcgc cgggttcatt ccggaaatga ctgcgacccc tccgcaaatc acaacggcaa 2634661 tgatcacaag gctcgccggg atgtaggaga atgtgtaatt caaatcgccc gcatcgccac 2634721 cgcttgtggc cgcaagaatc atcggaacgg ccaggttgac aaggtagctc acgccgtaag 2634781 aaatgataat cccaatcaca cagcctaaaa ttccgatata cgcgctttcc atcaagaaca 2634841 ttcggcgaat gattgacggg ctcgccccaa tcgctttcat aatgccgatc tcttgcgttc 2634901 tctctgtcac cgccatcgtc atcgtgttaa aaatgccgat cgctgaaatg ataactgcga 2634961 tacatccgac aaagatcagt ccgattttga agaccatgaa gaaggtattg gctccctcaa 2635021 gttcagtagt cactgatgtg acatagtacc cgtcatctgt tagatcattt gtcagctgtt 2635081 ccacattctc aaacttatca gcaaaaacac caatgttcgt ttcaacattt ccgcctttga 2635141 aatctaagaa ttccgaaaaa tcttttttga attgatcact gataaaaata tttgagtcct 2635201 ccatccagtc ttgagatggt ttttttgtaa taccgacaat tttaaagtca tatgtttttg 2635261 tttttgtaac atcccctgtt ttagaatctg tcttcgatac acttagttca attgttttat 2635321 ttagaatatc tttcgtatag ccctttggtt cttttatatc ttctggattt ccttttgctt 2635381 cctcgatttt tttgttatat tcttccgatt cttttttcgt taataatctc tttgcgaagt 2635441 cgtatcctac tacgatttca ttttccgact ttgcgactct tcccttttcc aattccatat 2635501 tggcctttaa ttcatcattc atattagtaa aaatgagatt tgagctttca tttgtacgat 2635561 tgcctaaagt agctttgttt ggttcataca cttgcgttct ttctacaact gaccttacgt 2635621 gatcatactt ctctaaatca gcttttttaa tcggcttgtc tccttccttg cccattacgc 2635681 tgactttcgt tacaatctgc tggctcattg tcatatctgt aatcgtcttt tgaatcccaa 2635741 atccaacgga cgacaacaca accaaaaacg cacacgccat tgttgtcgcc agaatcgtca 2635801 taaagacgcg aagcctgttt ttcttcatat ttcttctgat aaaatgaacc tgatccttaa 2635861 acctcaacgg taattcctcc ttttagcaca ccatcatgaa gctgaaattt tgaatgtccg 2635921 atagaagcga cttcatcatc gtgagtaatg atcacaaatg taatgccacg ctcacgattc 2635981 agctgctgga tcaattccag cacttcatgt tccgtttctg aatcaaggct tcccgtcggc 2636041 tcatccgcta agataatcga aggatttaaa atcaatgctc gagcaatact gacacgctgc 2636101 tgctggccgc ctgacagttc attcggataa tgagcggcgt ggttttccag accgacgcgt 2636161 ttcagcatgt cctgcacctt ttgcttccgc tcagatggct tgattccttt taacgccagc 2636221 ggcatttcca cattctcata cgtcgttaaa cccgggatga gctgaaagct ctgaaaaata 2636281 aacccgaaat ggtcaagccg aaattgcgcc cattcctttt cattaaaccc cgtaacatca 2636341 gtgccattaa tgacaatccg cccttttgtc ggcgatatgt agccggaaat taaattcaaa 2636401 agcgttgatt tccctgagcc gcttcgtccg acaatgcagg cgatttcccc tttcgccacg 2636461 ctcaatgaaa catccttcaa tactggaact tcattctcac ggcccttttt tccgatcgtg 2636521 aaagaatggt cgatatgctg aacatcaatc atatgttctc tctcccttac aaaagtttca 2636581 tttttttata aatcgcaaaa taactaatca agaaaccgat taccgcacct gtacccatgc 2636641 caatgagata accggcaaag ctctcgcttg cagtaaatcc aaaatagccg aagcccatga 2636701 ttcctatgat aataacgatg atctgcaccg ggcggttaag cggcttccat aagaagaaat 2636761 atccgtttct ttcattagac attttaacaa agctaatata gccgatgatg taaaaaatga 2636821 tagtcatgat agccggaatg actaaataat atggtgaatt ctcagcccat ttcgagtcta 2636881 cataaattat cggaatgaaa tactgcaccc atttaggtac tggaccatgg ataaaatcta 2636941 ttgatccgcc aaaaaggatc tcgaggttga tcacaggcag gctgatgagt aaaaacggcg 2637001 aaatggccac ggtaaatgag actagaagct gtgcgaaact attgcctgtc aaagctcctc 2637061 cggccataac caaagaataa gccagcatgc taacaataat cattcccaag ctgtaattgt 2637121 gaaaataaac ggcctgatct ggcttcaaaa gcatgatcag caaaacagac aaaacataac 2637181 ctatgagctg cggcaccaca atcaccattc cgccggtaag gaacttcgca tgaaatatct 2637241 gccctcgtgt atatggaagg cttaatgtaa aatcaaagaa gctcttgcta cgttcaatcc 2637301 caagctggct gaccgccaaa acgactcccc aaatccaaaa caatgagata aatgagctat 2637361 ttaaataatc aacgctgaat acgcaggggc cgacccaatt ttcttttcca gtgacacagc 2637421 cttgatagat gagatacata tttaaaattg ataatggatt acctaatata aaaaccaaaa 2637481 tggtgataac taaggcgact ttattctgcc gccactcttt gtaaagcagt ccggaatccg 2637541 gcaactcact tccctccaaa cctaaggcat ttcttacact tttgttttct tataaataga 2637601 gaagtagctc acaaagaatc cagccactgc tccaatgatc atacccaaaa tataaccaat 2637661 aatggaatgt ccggtatagt atccaaataa accaaatcca aggatgccga aagccataac 2637721 cagaatttgc accgggcgat ctaatctgtt ccataagaaa aagtgtccgt tccgttcact 2637781 tggaagcttc ttgaagctta taaagccaat caagtaaaat agcatgctca ttacggctgg 2637841 aatcaataaa agatatttac tgttaatcag ccattcattt acaacgtaac taatcggtac 2637901 taggttcgat aaattgcttg ccagagagaa ataactctca ggggaaggga atatttccca 2637961 tatattcgca ccaaaaacaa cttctaggtt tccaaccggc aatgcaataa ttaaatacgg 2638021 caatatagct gctgaaaacg ccgttaacag ttgggcaaaa gcatttccag ttaacgctcc 2638081 ggcggccatc accagtgaaa aagccataaa acttatcacg attactccaa tgctgctgtg 2638141 ctcaaaaaag tagacgtgtt cagggttata gacaagaatc agcagccatg caagtaaaaa 2638201 gccaatcaat tgtgacagca caatcacaaa accgcctaac caaaattttg tctgaaaaat 2638261 ttggcttctg ttatacggga ggcttaatat aaaatccatc gtgcctttcg aacgctccat 2638321 tccgaggaag cagaccgcca aaatgacacc cggcacccag ttgatatcta tcagattgct 2638381 tatggaataa ttcacaataa aatcacaata ttgcgggtct tggcgatcaa gacacccttg 2638441 ataagacaaa tacgtattaa cgatagaaag cggatttgcc aatactaaaa acgcgatact 2638501 taacaaaatc accacttgat tctgcttcca ctctcgatag aggagacctc ggtctaccat 2638561 ctccgcttcc ctccaaactt cgcaatgaac acttcttcca ggttgacagg aagctcattc 2638621 cacacttttg gcttcagctc tctcaaaaag ctctttttct cctcatcgct tttcggaatc 2638681 agcactgtgt aaaacacgcc ggcctgatcg agcatcggaa tgttttgctc tctgatggcc 2638741 aaattgacat ctgtatcgaa ggccatttga attttaatgt attcttcttt taactcatca 2638801 agatccatga cgttggtcag gctgttatct tcaagaaaac caattcggtt gcacatccgc 2638861 tctatgtctt caagccggtg ggacgtaatc aggatgctcg tatcacgctc tgccacttca 2638921 tcgaccatca gctgcagcac atcatgcctt gtcaccgcat caataccatc cgtcggctca 2638981 tcaaggagga tcagcgccgg tctcgccgca aacgacagaa cgagcgatag ctgctttttt 2639041 aagcctgtcg acagctcacg gtattttttc gtttccggaa tttcgtatct gttcatcagc 2639101 tcattcgcgt acgtgacatc aaatttcgga tatattcttc tcaaaatatc gactaactgc 2639161 ttgtatgtat acttatcgta aaacggattt tgaacaggca tgtagatgat attttgtttg 2639221 actttcgggt gctttttgat ttctacgccg tcaaataaaa tcgttccgct gtcagcgaaa 2639281 atgatttgct ggattaagcg aagcatcgtc gttttgcccg atccattgcg tccaagcaat 2639341 ccaaagattt ctcctttttc gattgttaat gaaacatctt ttaatacttg attgccgtca 2639401 atcgcttttg acagctgccg cagttcaatc attttttttg cctcccttca catcagcgct 2639461 gatttccttt atccattcgt gcagtttttc cagctcaacc cctgcatagt gtgcatcgat 2639521 gatgagctgt ttgagttgct ctttaatcat cgtcatcttc ccttcaacca gtgtcgtttt 2639581 tgcattctcc gatatatagg tccctctgcc ccgcagcgtt tcaataatcc cctctcgctc 2639641 aagttcttta tacgctttgc tgacagtgtt cggattcgca ataatgatcg ttgccaattc 2639701 tctgacagaa ggaagcttat caccaggctt catgatccct ttcaaacaaa gctctttcat 2639761 ttgctgaata atttgttcgt aaatgggtgt tgagcttctt ggatcgattt gaatcattta 2639821 cttccctact ttctatacga tctgaacctt ttatagataa aaatgatcaa ttatactttt 2639881 ttgccattca aaaccgatca tcacaagaac aagaaaaaaa gaacaagcga tcacagatgc 2639941 cgcaatcagc attggcacgt tacgtttgtt tcgtttttta tgtttcataa ctgcctccct 2640001 taatgtcaat atataaatga ttttatatta gtgtctatag tgtattactt caattagtac 2640061 acttaataca ataaatactt tgactcacaa agtcaatcct ttttttacaa aaaaacggac 2640121 ccttttaaaa gggtccgttt tcctacacat caagagggtg ctgcaggatc atattatttt 2640181 gcaaagattg aagctgaagt ctcattctgt acagctgttc tctctgctga tcatttgacg 2640241 acagccatag tttattcaag gcatttaccg catcttctag ctgcatttgt gcatcactat 2640301 attcttgatc gttataatgc tcttgtttag aagcgatttt cagctgttct tcagcataat 2640361 cataggcctg catacattgc tggagatgtt catctactga ttgtcttgtt gccacagtaa 2640421 cccctcctct tggtaatgga aatcatccat cattcatatt gtagcctcat ctgactttat 2640481 tcaataaagt aatttatggt cgatattcat ttgttctctt gtgaaatgcg tgctacaatt 2640541 ttaggatgca atcgtacgca aggaggcaca tgaattgtga tgcagaacaa tccttttcct 2640601 tattcaaata cggaaaaacg ctatcataca ttgaattatc atctcagaga acatttcggc 2640661 cataaggtgt ttaaagtagc gcttgacggc ggttttgact gtccaaatcg ggatggcacc 2640721 gtagcccacg gaggctgtac gttttgcagc gcagcaggct ccggagattt tgctggaaac 2640781 cggaccgatg atttaattac gcaattccat gacatcaaaa accgcatgca cgaaaaatgg 2640841 aaggacggca agtacatcgc ttattttcag gctttcacaa acactcacgc cccggttgag 2640901 gtgcttcgtg agaaattcga atccgtcctc gccttagatg atgtggtcgg catttcgatc 2640961 gccacacgcc cggactgtct gcctgatgat gtcgttgatt acttggcaga gctgaatgaa 2641021 cgtacgtatt tgtgggtgga gcttgggctt caaacagttc atgaacggac tgcacttttg 2641081 atcaaccgcg cacatgattt taactgctat gtggaaggcg tcaataaatt aagaaaacac 2641141 ggcatacgtg tctgctcgca tattatcaac gggctgcctt tggaagaccg ggacatgatg 2641201 atggaaacgg caaaggccgt cgcagatttg gatgtccagg gcattaaaat ccatctgctt 2641261 cacctactga aaggcacgcc gatggtcaaa caatatgaaa agggcaagct ggaatttctt 2641321 tctcaagatg attatgtgca gctcgtctgc gatcagcttg agatcattcc gcctgaaatg 2641381 atcgtccacc gcattacagg tgacggaccg attgagttga tgatcgggcc aatgtggagc 2641441 gtcaacaaat gggaagtgct tggcgccatt aataaagagc tagaaaatcg aggcagctat 2641501 caaggaaagt tctttcaacg gcttgaggag gaatcagcgc tatgattttg aagaaaattc 2641561 ttccttacag caaagaactg ctgaaaatgg ccgcgggaga gggagatatt gtcgtagatg 2641621 cgacaatggg caacggacat gatacacagt ttttagcgga gcttgtcggt gaaaacggcc 2641681 atgtatacgc attcgacatc caagaatcag ccgtggccaa tacaaaggaa cggctcggtg 2641741 acatgtatca agcgcgaaca acgttatttc acaaaagcca tgataaaatc gctgaatccc 2641801 tcccgcctga aacacatggc aaagtggcgg ccgcggtatt taacctcggc tatttgccgg 2641861 gcggggacaa atcaattacg acaaacggca gttctacgat caaagccatt gaacagcttc 2641921 tcagcatcat gaaagacgaa ggtctgattg ttctcgtcgt ctatcatggc cacccggaag 2641981 gcaaagctga aaaaaacgac gtgctcgagt tttgccggga cttggaccag caaacagccc 2642041 gtgtattaac atacgggttt atcaatcagc aaaatgaccc gccatttatt gtcgccatcg 2642101 aaaaaaaagc tcagatcagc aaatgatttg agcttttttc tttgaatttt tcatccagga 2642161 cattttttga aatttccggt aggctctgcc gttgatataa aagaaaaggg aggtttttcc 2642221 gctggctttg atcagcttct ttgcgagccg gacctgcttc gtcttacttt accatttttc 2642281 aaattatatt tgaaagcaat aaccatcgtt aacccggacg tcatacagtt cgggtttcga 2642341 tttttccata aaacgttcac atatagcatg aaacgtatga cttttatctt atcacaaaac 2642401 tataaacagc ctctgcaaaa acacatacct attctttcct gttctctatt ttctatgagc 2642461 acacacaaaa agagcccact gggagctctt tttgtcagct gatatttcgt tcgctggcag 2642521 cagccgcatt ttttttatga aacccttttc catagtacac agccagcaag atgagaaacc 2642581 atatcggccc gataatcacg gctactcttg tatcagggct gtaagccata agaatgacga 2642641 cgaatgctag aaatgccaat gacacataag acgtaaacgg aaataaaggc attttgtact 2642701 ttaattgttt cttttcttcc ggcttcaaac ttttcctgta ttttatttga gaaagcaaaa 2642761 tgattgccca cgtccaaatc gctccgaacg tcgcaatact tgtaacccaa gtaaatacct 2642821 tcgcagggac aacatagttt aacagcactc cgactaataa agcgcccgct gaagccagaa 2642881 cagctttacc cgggatgccg cctttcgtca gctgaccata tgcttgtggc gcctctttct 2642941 gttccgccaa gttaaacagc atccgccctg tgctgaaaat accactgttg catgaagaca 2643001 gcgcggctgt caacacgaca aagttaatga tacctgcggc cgatggaatg cccacttttt 2643061 gaaatgtgag aacaaatgga cttccttgag agccaatttc ctgccacgga taaatagaca 2643121 taatgacaaa taaagcgcct acataaaaaa tcaaaatccg ccaaaatact gtatcgattg 2643181 ctttggctaa cgatttttgc gggtttttta cttcgccagc cgtcaccccg atcatttcaa 2643241 tccctaaata ggcgaacatg accatttgaa gagacaataa aacccctttt aatccatgag 2643301 ggaaaaatcc tccgttgttc cacaaattgc tgattccggt tgcaatgccc ccattgccga 2643361 ctcctgcaat aatcatcaat aaaccgacag caatcatgga taagattgca acaattttaa 2643421 tcaatgcgaa ccaaaattcc agctcgccgt aagctttgac agccaggaaa ttaacacccg 2643481 tcataatgac cagtgccgat aacgcccaaa tccagtttgg cacgtccgga aaccagaacc 2643541 ccatatagat gccgacagca gtgatttcgg ccatacaggt gacaacccat aaaaaccagt 2643601 agttccaacc tgttaaatag cctgcaagcg gtcccaaata atcacgcgca tacctgctga 2643661 aggagcctgc gaccggtttt tgaatggcca tttccccaag cgctctcata ataaaaaaca 2643721 tgaccaggcc gcttgcggca tacgctacca aaataccagg ccctgctaat tgaatagctg 2643781 atgcggagcc gaggaacaac cctactccta tagcagctcc taaagacatt aaagaaatat 2643841 gcctttcttc gagtccgcgg tgcagctctt gtttttgttt ttgcatgctt cttctcccct 2643901 agaaaaaaat atcattatat catttttctg aatattccgt acggattggg taaatcaatg 2643961 atgatggaga aataaaagga taacaacaag gctttcgact actcgaaagc cttgttgtct 2644021 gttacacaaa gatgacttct ttaggctgat ggctcagctc ttcaggcata taccgttttt 2644081 caatattgat gctgtgccag atcataaaga ttagcacagt ccaaatttta cggctgttat 2644141 cagccttgtc cgcacaatgg tcttcaagaa gctgaaggac ataatcctta tggatataag 2644201 catccgtttg gctttcttga ataatattcc gcacccattc gttcatttcg tttttcagcc 2644261 aatgacggat cggtacaggg aaaccaagct ttttgcggtt taatacgtgc tcaggcacaa 2644321 ttccttcagc ggctttgcga agaagatact tcgtcgtgcc gttcttcgtt ttcagctcat 2644381 caggaatttt tgaagcgacg tcgaatacga ctttatccaa gaacggcaca cgcagttcca 2644441 aagaattcgc catcgtcatt ttatccgcct ttaacaaaat gtcgccgcgc atccaagtgt 2644501 ggatatcgac atactgcatt ttgttgatat cgctgtacga gctgctttct gtaaagtaag 2644561 tcttcgtcac atcgcgatat gaaaggttcg gattataatg cttcaacagc tgctttttga 2644621 cagactcttc aaagattttc gcgttaccga tataacgatc ctgaagcgga gtgcagccgc 2644681 gctcaagcag gctcttccct ctcatacctt caggcataac ggcagcaacg tgcagaagca 2644741 tctttttcaa gccggacgga atccgttcaa acggtttaag cgaaagcggt tcacggtaaa 2644801 tgttatatcc gccgaagagc tcatccgctc cttcacctga taaagcaacc gtaacatgtt 2644861 tttttgcttc ttttgcaaca aagtacaacg gaatcgctgc cggatcagca agcgggtcat 2644921 caaaatgcca tacgatcttc ggaagctcat tcatgtattc ctcaggcgaa atgactttgc 2644981 tgatattttc aatgcccagc gccgctgccg tttctttcgc tacatcaacc tcactgaagc 2645041 cctgctgttc aaagccgaca gagaatgttt ttaagcttgg atgaaattcc ttcgcaacag 2645101 acacaataaa ggaagaatca atcccgccag acaggaacga accgacagga acgtcacttc 2645161 tcatatgaac gtttacagag tcatagatcg cgtctcggac ttctttcaca agcttgtctt 2645221 cttcagtctg aaccggcttg aagttcgctt tgaaatacgt tttgaatgtg atatcgccgt 2645281 ccgggcggat tgtgaattgt gaacccggct ctactttttt cacatgggca tcaagcgtgc 2645341 ttggttcagg aacaaattgg aaagacatgt actgctgcaa tgcctcttta tctatttcaa 2645401 tatcattctg agcaaccatt aaactttttc tctctgaggc aaaataaacc tgatcattga 2645461 tcgttgtgta gtacaacggt ttaatgccga atggatctct tgccccataa agcacatgat 2645521 cgtttttatt ccaaatcaga aaggcaaaca taccgcgcag tttggacgcc gcttcttctt 2645581 tatagtgacg gtaagtcgca agaagaacct ctgtgtccga atccgtgttg aatgtgtacc 2645641 cctttgcttc aagttcttct ctcagttcga tatagttata gatttctccg ttaaagataa 2645701 tccaatatgt ttcatcttca tatgataaag gctgtccacc attttctaca tcaataatgc 2645761 tgagccgtct gaatccgaag ccgacgtgct catcatggaa atatccatca ctgtcaggac 2645821 cgcggtgaac gatcatttgg ttcatttgtt tgattagttc ttcttgatca gcggtttgag 2645881 ctaacggatg cttgttaaaa accccgacaa atccacacat agtattgcct ccataattaa 2645941 aattgtcatc attgaacccc tatttataga cgctgtgaat agtatttggt ttcacagtta 2646001 tgtaaaaaaa taaacatgaa tacaacgata aaaaagggaa agccgcttaa ccagtaagcg 2646061 gctataaaat tattctccta acgcttcttt acgcagctgc tccgctttgt ctgtgcgctc 2646121 ccatggaagg tcaacatcgt gacgtccaaa gtggccgtac gcagcagttt gtttatagat 2646181 cggacggcgc aaatcaagca ttttgataat gccggcaggt cgtaaatcaa agttattgcg 2646241 aacaacttca atcagttttt cctcagaagc ttttcctgaa ccgaatgtgt tgattgagat 2646301 tgacacaggc tgtgcaacac cgatcgcgta agcaagctgt acttcgcaag aatcagcaag 2646361 ctcagccgca acgatgtttt tcgcaacgta tcttgccgca taagctgcag aacggtctac 2646421 cttcgtcgcg tccttacctg agaacgcgcc tccgccgtgg cgtgcatagc cgccgtacgt 2646481 atcaacgatg attttgcgtc ctgtaagtcc cgcatcccct tgagggcctc cgattacgaa 2646541 acgtcctgta gggttgatga aatattttgt ttcttcatca atcagctctt caggaacaac 2646601 cggattgatt acatgttctt taatgttgcg ctgaatttgc tcaagtgtaa tttcagggtg 2646661 atgctgagtt gaaataacaa tcgcgtcaat gcggactggt ttgttatttt catcgtactc 2646721 aaccgttacc tgtgttttgc cgtcagggcg aaggtacgga agaatatctt ctttacggac 2646781 ttcacttagg cggcgggcta atttatgggc aagtgaaatt ggaagaggca taagctcttt 2646841 cgtttcgttg cacgcataac cgaacattaa tccttggtca cccgcaccaa tcgcttcaat 2646901 ttcttcgtcg ctcattgtgc cttcacgggc ttcaagcgct tggtctacgc ccatcgcgat 2646961 atcagcagac tgctcatcaa ttgatgttaa aaccgcacaa gtttccgcat caaatccgta 2647021 ttttgcacgt gtgtatccga tttctttaat ggtttggcga accgttttcg gaatgtcaac 2647081 atacgtagaa gttgtgatct ctccgcttac aagaaccaaa cctgttgtca cagatgtttc 2647141 acaagcaaca cgcgcgttag ggtctttctt taaaatttca tctaaaatgc tgtcagaaat 2647201 ctggtcacag attttatccg gatgcccctc cgtaacagat tctgatgtaa ataaacgacg 2647261 atttttactc atgatttgct tcctcctgca caaggcctcc cgaaagacct tgtatatatg 2647321 atacggaact cgctccctct tatacaatgt acagttatat tagagaatgt taattggcat 2647381 atttatgaaa taaaaaaacc ttttccatcg aggaaagggt ttggtctttg tgcctttcac 2647441 tcttatcgct caaggaatca tacaaccttg caacaggtta gcaccttggt tgtctcactc 2647501 agttgaacat aataaataac agagaaaccg gttgctgggc ttcatagggc ctgtccctcc 2647561 gccagctcgg gataagagta tccgctcaat gaaatatctt atcgtaaaag ggtttgcaat 2647621 gtcaatatga ttcagaagaa ataggcacct atattgaggg aaaacaatgg aaatgcacac 2647681 acaaaaaaca ataaatagta tagactattt gaaaatatat gttatactaa ttcacaatta 2647741 gcaaaacaca aaaaacgata aaggaaggtt tcatatgaac tcagttgatt tgaccgctga 2647801 tttacaagcc ttattaacat gtccaaatgt gcgtcataat ttatcagcag cacagctaac 2647861 agaaaaagtc ctctcccgaa acgaaggcat tttaacatcc acaggtgctg ttcgcgcgac 2647921 aacaggcgct tacacaggac gctcacctaa agataaattc atcgtggagg aagaaagcac 2647981 gaaaaataag atcgattggg gcccggtgaa tcagccgatt tcagaagaag cgtttgagcg 2648041 gctgtacacg aaagttgtca gctatttaaa ggagcgagat gaactgtttg ttttcgaagg 2648101 atttgccgga gcagacgaga aatacaggct gccgatcact gtcgtaaatg agttcgcatg 2648161 gcacaattta tttgcgcggc agctgtttat ccgtccggaa ggaaatgata agaaaacagt 2648221 tgagcagccg ttcaccattc tttctgctcc gcatttcaaa gcggatccaa aaacagacgg 2648281 cactcattcc gaaacgttta ttattgtctc tttcgaaaag cggacaattt taatcggcgg 2648341 aactgagtat gccggtgaaa tgaagaagtc cattttctcc attatgaatt tcctgctgcc 2648401 tgaaagagat attttatcta tgcactgctc cgccaatgtc ggtgaaaaag gcgatgtcgc 2648461 ccttttcttc ggactgtcag gaacaggaaa gaccaccctg tcggcagatg ctgaccgcaa 2648521 gctgatcggt gacgatgaac atggctggtc tgatacaggc gtctttaata ttgaaggcgg 2648581 atgctacgct aagtgtattc atttaagcga ggaaaaggag ccgcaaatct ttaacgcgat 2648641 ccgcttcggg tctgttctcg aaaatgtcgt tgtggatgaa gatacacgcg aagccaatta 2648701 tgatgattcc ttctatactg aaaacacgcg ggcagcttac ccgattcata tgattaataa 2648761 catcgtgact ccaagcatgg ccggccatcc gtcagccatt gtatttttga cggctgatgc 2648821 cttcggagtc ctgccgccga tcagcaaact aacgaaggag caggcgatgt accatttttt 2648881 gagcggttac acgagtaagc ttgccggaac cgaacgtggt gtcacgtctc ctgaaacgac 2648941 gttttctaca tgcttcggct caccgttcct gccgcttcct gctcacgtct atgctgaaat 2649001 gctcggcaaa aagatcgatg aacacggcgc agacgttttc ttagtcaata ccggatggac 2649061 cgggggcggc tacggcacag gcgaacgaat gaagctttct tacactagag caatggtcaa 2649121 agcagcgatt gaaggcaaat tagaggatgc tgaaatgata actgacgata ttttcggcct 2649181 gcacattccg gcccatgttc ctggcgttcc tgatcatatc cttcagcctg aaaacacgtg 2649241 gaccaacaag gaagaataca aagaaaaagc agtctacctt gcaaatgaat tcaaagagaa 2649301 ctttaaaaag ttcgcacata ccgatgccat cgcccaggca ggcggccctc tcgtataaaa 2649361 aacaaaagcc aagagcaatt atgctcttgg cttgttttaa ttgacggaat gcaaagaagt 2649421 cagcttgtat gtaatgatgg tccggccttc ttcccattga agcttctgca cttcagctgt 2649481 gcctgacttt tcgccaaact ttgttttgcg tacatccatt ggaatctcca tcggatatac 2649541 tcggtatccg tccttctcta acgtgaatat attttcatct atgcgaactt cttttccttt 2649601 tgtcacaatc agtgtattaa attcaacagg cattcccaaa gtgaaatccc ctttcgttct 2649661 cttttttctt tatcataaca tatttcactg tcagcggttt ttcatccatt gtgtgagctg 2649721 ccgcacgata cgccggtttt cttttggcgg gaaataatgt gtgaatgtac tgtagtacca 2649781 tgtttccacc ggcttatgca gttgttttag cttctcttct aataaatagg aatgctgaat 2649841 cgaaacattt tggtcttttt ctccatggat taacagcacg ggagcctgaa ttttgtttac 2649901 ttggtcaaac ggtgtcctcc attgatattc ctcaggcacc tttttcggtg ttccgccgat 2649961 gactcttttc atcattcgcc gcaaatcctg ccgctcctcg tatgtaagaa tcatatcact 2650021 gacgcctccc caggaaacaa atgaagctgc ctgcccgccc atttcgatcg cagtgagcat 2650081 tcccataatt ccgccgcggg aaaaaccgaa gatatggatt ctatccttct tgacatttgg 2650141 gtgctgctga agcaggcgaa aagcagaaaa tgcatcctcc ctgtcttctc cggcaaaatc 2650201 ctcattgcct tctcctcctt gattgcctct gtaaaaagga gcaaacacca caaacccttg 2650261 ggatgcaaac tggataatcc ggcccggccg aaccatgccc acgcttttaa tcccgccgcg 2650321 caaatataaa aatccgtcat attgtcccgg ttccgccggc tcagccagaa gccccttaac 2650381 ccgtaatcca tttgacagat agcagatcgt atacaaacgc acatgctggc ttggcgacgg 2650441 aaatcttctt ttctctacaa tcaaaacagc cgcctccttt tttctatatg ctttccttac 2650501 tccaaaatta catccggaga acctggttag gcattcacac atttttatac ccatcatacg 2650561 atatgtaaag caaaaaagga tattaacttg atgcgaaata aggaggttgt ctatgtgaac 2650621 agatggttaa ggctgggctt cgcctgtgtc ggcagtatct ttctgatgtt cgccctggcg 2650681 gcttgcaagc aggaagaaac gctcaccaaa gtcaaagtag ctgaagtgac ccattcaatt 2650741 ttttacgcac ctttatatgt tgctgagtct aaaggttttt ttaaggaaga agggcttgat 2650801 gtcgatgtga atacgacctg gggcggagat aaaacgatga catcgcttct ttccaacggc 2650861 tccgacatcg cgcttgtcgg gtcagaaaca tctatttatg tcgaagcgca aggggctaaa 2650921 gatcccgtca ttaatttcgc ccagctgact cagacagacg gaacgtttct tgtcgcgaga 2650981 gaagatgttg aacacttcga ctgggatcag ctgaaaggaa aaacgtttct cggtcagcga 2651041 aaaggcggca tgccgcaaat ggtcggcgag tatgtactga acaaacataa gattgacccg 2651101 cataaggata tagacctcat ccagaacata gacttcgcca atattgccaa tgcgtttgct 2651161 tctggaaccg gtgagtatgt acagctcttt gaaccgcagg cttctctctt tgagaaaaaa 2651221 ggcatcggcc atatcgtggc ttcattcgga gaagaatcag gagaggttcc ttatacgact 2651281 tttatggcga aacaaagcta tttgaagaaa aatgaagaca cagccgtcaa gtttacaaaa 2651341 gccatttata aggcgcagca gtgggttgaa aatcattctg cgaaggacat cacagatgcc 2651401 attaaagatg aatttgatga taccgaccca gacgtcatcg aaacatccat tgaacgctat 2651461 aaaaaacagc attcatattc accagaccct ctgcttaacg aaaaagaatg ggagcttctc 2651521 caaaccatta tggataaatc gggagaactg ccgaagcaca ttccatacaa tcagcttgta 2651581 aataaagaaa ttgctgaaaa agtcacctcg gagaaatagg aggcgccatc tatgtctttc 2651641 ttacatgtcg accatgtaac ccatacttat ttttctatta aagaaaaaac aacggctgtg 2651701 cgggatattc atttcgatgc cgaaaaaggc gatttcatct catttctcgg cccaagcggc 2651761 tgcggaaaaa caacattgct ttccattatt gccggtttga ttgagccatc agaaggcaga 2651821 gttctgattg aaggccgtga gccgaatcaa aaagaacata atattggcta tatgcttcag 2651881 caggattact tatttccctg gaaatctatc gaggaaaatg tgcttctcgg tttaaaaatc 2651941 gccgacacgc tgacagaaga aagcaaagcc gctgcactcg gtctattgcc ggagttcggc 2652001 ctcatagatg tggagaaaaa atatccgaaa gaactgtcag gcgggatgcg ccagcgggct 2652061 gcgcttgcaa gaacacttgc gcctaaccct agtctgcttt tgctggatga gccattttcc 2652121 gcgcttgatt ttcagacaaa gctgtctttg gaaaacctgg tattccgcac attaaaggaa 2652181 tatcaaaaaa cagcagtgct tgtcactcat gatatagggg aagcgatagc gatgagcgat 2652241 acgatctttt tattttcaaa tcagccgggc accatccatc agatttttac cattcctaag 2652301 gaattggccg cgatgttgcc ttttgacgcc cgtcaggaac cttccttcca gacactgttt 2652361 caaacgatat ggaaggagct gaattctctt gagaaacagc aaagaaacca ttgatctgct 2652421 tcacgagcag tatcaattca aacagaaaaa ggaaaagtgg aaggtccatt cctttcagct 2652481 tgccatattt attctctttt tctcgggctg ggaaatctcc agcaggcagg gctggatcga 2652541 tccgctgatc ttcagctctc catcagctgt gtggcgatta ttgctggaga aacttggtga 2652601 cggttcttta ctgtcacaca tcggcgtcac tttatttgaa acggtgcttg gctttttgct 2652661 cgggacgttt atgggcacgt gcctagccgc tttgttatgg tggtctaacc gacttgccag 2652721 aattttagat ccgtatcttg tgattttgaa cgcaatgccg aaagtggccc tgggcccgat 2652781 cctgattgtc gcgctcggtc ccagttttat cagcatcatt gcgatgggag ccatcatcag 2652841 cgtcattatc acaaccatcg ttgtctacac cgccttccaa gaggtcgacg aaaactatac 2652901 gaaagtcatg aaaacattcg gcgcaaaaaa gtgggttatt tttaaagaag tcatactgcc 2652961 tgcatcctcc cccgcgatta tttcaacact aaaagtgaac gtcggtttat catgggttgg 2653021 cgttattgta ggggaattcc tcgtttcgaa ggtcggatta ggatatatga ttatttacgg 2653081 attccaagtc ttcaatttta cactcgtctt cttaagcctg ctgatcatcg ccatcttcgc 2653141 cactctgatg tatcagggcg tcgagctgct ggaaaagaaa tggacgaagg ggaggacata 2653201 aaaaacccgg cacatgtgcc gggtttttta ttcaatccat ccagattctt tcagtttttt 2653261 caagctgatc ggaagaacgg aatccttcat aataaagctg aattttttat tgcgggaaag 2653321 gttctccggc agctcgtgaa acaaaaccgg gcctttcgtt tcaaagtaat cagcctgctt 2653381 ttcaagcttt tctatatctg caaaatatat attttttaca atcacttttt cttttccgag 2653441 aactttatac tgtccgagat acttgaggct tttgactctc gcgcccgtct cttcctttac 2653501 ttcccggagc gcagcctctt ctgcgcactc catcggctct actttcccgc ctggaaactc 2653561 atagcctctg tcctcatgtt ctgttaaaag ccatttgccg ccaaaacggc aaatcaccca 2653621 gacatgcttc gggctgtccg agaaaggctg atcgtcaaag gaaagctgaa cagtattctg 2653681 ataataatct ttaaactcgt acatgtttat ccctcaaatc cgttcctagc tatcttccat 2653741 acatcatacc acagttacgt ttcttcggaa gccttttatc aaaaaataag ggaaacccag 2653801 cacgccgtca ggttctgcat gcagactagc tcgtacagtt tttttgcgat acttttgccg 2653861 gaaagtgcga ccgacgctct gggctttatt atgacccgcg aacagggaaa agttacggtt 2653921 tgcgcttaaa tttatttttt aacgtttcta aaagatcgac aagcatctga ggaaccggta 2653981 tgccaagaga gctggctgtc acaacaattt gcacagattc ataaagaata taaaacataa 2654041 tagccaagtc acgaattgat ccctgtgtat tcagcagctg atcaaaaaag tggcatacag 2654101 agatcagagc cagcgtgact aattttttga caagccgggc aaataccttt ttaaatgaca 2654161 gtttgtgaat aatggtttcc ttcaaagtcg tactgataaa ttcaattgcc ataagagaga 2654221 gcaaaatcag aaatgaatac tgaaaacctc caaagaaaaa acccgctgct gaaacgctga 2654281 ctgctaaaaa cgaaaagatg ccaaagtctc tatccattta tcccaacatc ctttcacaga 2654341 aacggcctta cgatattcta tggtaaacaa gccgaacgga ttggattttt cagaaaaatg 2654401 gactggttgt cgcctatttt tcagatacaa aaagaaaagc cggacgtctt ttttaagaca 2654461 tccggccgtt ctatttttga acttaaccta ggtaagcttt tagcatccag ttatgttttt 2654521 caatattttg atggatcgca agaagcatgt cccctgttgt ttcgtcaccg acttcatcag 2654581 ctaaatccat gccgtttttc agctcttccg cgatgactgt gaaatcatca tatacgcttt 2654641 gaaccatttg ttcagctgtt tcatttccag cagcttcttt gacagaagcc gtttctaagg 2654701 attccttcat tgttgcaatc ggttttccgt tcagcgccaa aagacgttct gctaagtcat 2654761 caatataagt tgctgtttcg ttgtacagct cctcaaactt ttcatgaaga gtgaagaaat 2654821 ctttcccttt cacataccag tgataattat gtagtttcac atacatgacc gtccagttgg 2654881 ctacttgttt gttcactgct tgaatcaatt gttctgacat ggtatctcct ccttgttata 2654941 tgactatgta tacccttaat atcgtacgct aaaacctctt ttttaccctt atctgtcacg 2655001 atttcttcta ttatgctaca attgttaaaa aacgggaggt ggaatgtcat gacgcttctc 2655061 attacgataa gtattttgat tgtgctggct gttttgcttg taaccatttg gacgactgta 2655121 aaagcctata atgtaaagca taccattgat ccaccacaag aaaatcactc tgattcacac 2655181 aatcaatgat gatgtgaatg ctcctcttct gactgattgc tggcagcatc ggcgtctccg 2655241 acttggactt ttaaggtcgg catgctatgc tgtttttttg ctgtgacatg agattggaca 2655301 gtgtatacac catcttcctt aaacgtcgtt tccaatcggt atacgccttt ttcttgtttc 2655361 accttaaaca tttggcttgc gtctttttcc ccttctttcc atacttcaaa ctctacttca 2655421 tcggcatccg tcacagcttc atcaccatat gatacagctg cttcataagc agcgctttct 2655481 ccgggattta ctttttcagg cccggtcagc ttgacatcca aaacctcggg cgtctcagct 2655541 gtatttgctt tactttcacc agatccgcat ccattaagca ataaagcaga aaaaagcaga 2655601 acaaccaaca tctttttcat gccatcaccc tttcatcgtt tacctaaata gtagcaaacg 2655661 cttacagcaa atggtacaca aaatatgaga cgtcacaaaa aagacctttt tgcttaagcg 2655721 caaaaaggtc ctttctattt tagccaaata cttttagcaa ttcttcttta tcctgtgaaa 2655781 gccagaaacg cattaaacgt ttagcgcctt ccagatcatg aagcttcgct tggccgcact 2655841 gcttttcatt cgcagcaggt atttctgtaa tctctaccgc ttccttcatt gtgtcttcaa 2655901 gcagatcaac gatttccgct gatgtcggct ctccgctcac aactagataa tagcctgtct 2655961 ggcagcccat tggagaaata tcaatgatat caaaatgatc gtatttctca gcgtgagaac 2656021 gaatcgtaaa cgcgagcaaa tgctcgagtg tgtgaatggt gtcaggcttc atcgcctgtt 2656081 tatttggctg gcaaaaacga atgtcaaatt tatttacaac gccgtctgtt cccactttat 2656141 gcacgccgca atgtcttaca tatggagcaa caaccgcatt atgatcaagc tcaaaacttt 2656201 ctactgaagg cataatggca ctctcccctt ttttaaaaat gtaatttcat tataacatac 2656261 ttttccgata agaattattg attaactttt caatctgtgt tttttttctt atacttgcat 2656321 cagaaaggtt gctgaagaaa catgaaaacc ctattcatcg ctctgatcag aggatatcaa 2656381 aaattcatct cgcccctgac accgccaacg tgccgctttt atccgacctg ttcccaatat 2656441 ggaatcgaag cgattaaaac acatggcgct ttaaaaggcg gatggctgac aatcaaacgg 2656501 attttgaaat gccacccgtt ccatccggga ggagtcgatc ccgttcctga aaagaaacaa 2656561 aaacattaat tgttataacc gtttacgata agatccagtt ttccggtttt aggatcaatg 2656621 actaagccat ggaccggaac gttttcaggg aacagcgggt gatgtttaat aacatctacg 2656681 ctgtctttca cactcgcttc cactgaatca aagcttttaa accattgatc aaagtctaca 2656741 ccggagtact ttattgtttc gatgcgttct tccggaatcc ctcttgcttt gattttttca 2656801 agcatgcttt tgctgctgat tttgctcatg ccgcaatcgt gatgcccgat cacacacacc 2656861 tcatctgcat tcagctcgta cactgcgacg agtatacttc tcatgatgct tccgaatggg 2656921 tgtgtcacaa gcgcaccggc acttttaatg attttcacat caccgtttcg caaattcatc 2656981 gcatgcggca gcagttcaac cagacgagta tccatgcaag aaagaatcgc cattttttta 2657041 tctggaaatt ttgatgtttg atacttttca tactctcttt gttcagtaaa tgtcttgtta 2657101 aattcgagaa tatcatttag aagactcatg ttcgttgtcc ctttctattc tttttactct 2657161 tcaatatatc acaacccttg tttattcgtc ataataaaaa aagacaaacc ctcaggcctg 2657221 ccttatttcc ccatgttata gcgttttttg aactgctcaa ctcgtccgcc tttttcattg 2657281 aatttctggc ggcctgtata aaacggatgc gtgtcagagc ttacctctac tttaatgaca 2657341 ggatatgtgt ttccgtcctc ccactctgct gtttcattag atgttttcgt agaggtgctt 2657401 agaaaacggt agccgctgtt gacatcctga aatatcactt tgtggttctt tggatgaatt 2657461 ccttctttca tgggtatctc ctttcaataa atcgtaataa ttacgtttta ttttataacc 2657521 ttacaaacgt tttgtcaatc ttcttatatc cttccctctg tttcacatcg taaacctcat 2657581 ggcatttaag aataggaaga ataatctaac cgaggaagca aataataaac ccaaaataca 2657641 tacagaacgt ctttttggaa aggtggttta cgattgtgga tgatttagtt ttggccagaa 2657701 gcctttttgg cacgacgatg ggctttcata tcattttcgc aacacttgga gtcggtctgc 2657761 cgctcatgat tttagtggcg gaattgatct atcaaaaaac gaaagatgac cattatgcga 2657821 tcatggcgaa aagatggacg aaagcacaag ccgttttgct gggggtcgcc ataccgaccg 2657881 gaacgatcgc gggcactcag ctcgcgcttt tatggccggg atttatggaa gtcatcggcc 2657941 gggtgatgtc cctgccattt caaattgaaa tctatgcttt ttttgttgaa gccctattca 2658001 tgtcgattta tgtatacgct gcagaccgtt tgtcacctgc aatgaggatt gttgctgttt 2658061 tctttgtgtt agtcggggca gcagcatccg ctgttctgat cacgaatgtt cacgcttttg 2658121 aaggtacgcc cgccggtttt aaaattttaa acggaaaaat tacagatgtt gacccgtggg 2658181 ctgcgttttt taatcctagc ttttttatca ctgccggcca tgtcgtgctg tccgcgttta 2658241 tgactggtgc gtttatcgtg gcttctgttg cggcgtataa aatgatccga acgaggaaaa 2658301 aggaaagggt ctatcgcttt caccggaaag cccttttgct cgcactgacg atcggcggta 2658361 ttttttcatt gctgaccgct ttgaacggac acgaatctgc acagatgctg tacgaatacc 2658421 agcccgaaaa attagccggt gcggaaggcc tatttgaaac aagatcccac gccccgctcg 2658481 ctatcggcgg ttttaccgac ccgaatgaag aaaaagtaaa atgggcaatc gagattccat 2658541 gggctttaag ctttttggca gcgaaccgtt ttgacactgt tgtaaaagga ttaaatgcat 2658601 ttccgagaga tgaatggccg ccgcttttca ttcacacgct gtttaatgcg atggttggtg 2658661 taggcatgct gctaattctt tattccatta tcggtgtggt ctggagaaag gtgctcaaga 2658721 aagaccgttt cccaacgtgg cttttgatca ttttcatgac agcaggccct tttagtctca 2658781 tcggcattga attcggctgg attttcgcat gtacggggag gcagccttgg gtcatctatc 2658841 atctgctgaa aacgtcagat gtcgtaacaa cgactggctc gatcggggtg ctgttcttat 2658901 ttttcacatt tgtttatgcc gtgttaggcg cagctgtcgt ctacgtgctg ctgtattatt 2658961 tccgcaagca cccggttgac gaagatttaa atacagcgga gtcgtaatgg ctccgcaaac 2659021 aggaaaccaa atggaaggaa gatcgtacaa atggagattt caactgacgc tctgatcgcc 2659081 atctcaatta tctggggctt tgtgtttatt tacgccgtca tggcgacaat ggattttgga 2659141 gcgggatttt ggtctatgat ctatttaaac aaggagcata tgaaggccac cgatattgcg 2659201 aatcgctttt tgtccccgac ttgggaggtc acaaacgtct ttattgtggc catcgtcgtg 2659261 gcgcttttca gttttttccc cggcgcgaca tttgtgctcg gcaccgtttt attaattccc 2659321 ggaagcatga ttttgctgct tttagcaatt cgaagcggat ttctcgtgtt ttcaaataca 2659381 gcaaaggagc ggaaaacgct aagatatatt tccggcatct ccggctttat cattcctgct 2659441 attttaattt tggtgcttcc tgtgacacac ggagggttta tagaaaaaac ggatggaatc 2659501 tataacttaa atatgtctaa aatcttttca agccccaacg cctattcatt tatcgggttt 2659561 gcgattttaa gcaccttatt tttgtcctcg ctgttgcttg cagatttttc aaatgtggca 2659621 gaggaacagg atgcgtaccg agcctacaga aaaagcgccc tgattaccgg cccgatttca 2659681 ctgttgtttg ctgtatgcat tatggtaact atgcggaatg aagcaaactg gctgtacagc 2659741 ggaatgatga atgatttttc ttggattatt gcatcgttca ttacatttgt cattgctgga 2659801 atcgctcttt ttctgcctaa caaaagcttt ggtcaaaaca tcggaaaacc gcgtctcgca 2659861 cttgttgcga ttgggataca gtattttctc gcaagctacg cgtacgggcg ggcgcatctt 2659921 ccgtatatga tttatcccga tgtgacagtc atgtcaggct tcacagagcc agcaacgttc 2659981 agagcgctgt ttgcaacgta tatcgttgca tttatcattc tatttccggg cttctttttc 2660041 ttctggaaaa tgtttatgcg agataaacgc tatatccgcc aggaggaata gagggcaagc 2660101 cagccggcta tactaatcca gaacctttat aaggagggga tggcatggag cagaaaattc 2660161 tatgtgaggt caacaactgt tcttattggg gcaaaggtaa caaatgcacc gctgatgcca 2660221 tttatgttgt cagccatact ggtgaaacgg ctgaaaacag ccgggaaaca gactgcaaaa 2660281 cgtttaagcc gcatgattta taattaaaag aaagagctgc atcagccagc tctttctttt 2660341 tgcatgttga gtgttctcag ctttttagtt atgaccccgt ttgcaggtga aaacaaaaag 2660401 gcgcttgcat aacatacacc tgtcatggcc gccatcgctc ctgaaatcga aacattaagc 2660461 cacgttgcga agaaatagcc catgaccgcc gacagcccgc caatcaacgc gctgagaatc 2660521 agcatataaa gaagccggtc tgtcagcaaa tgtgccgcag ccggcggaac aatcagcatg 2660581 gccacaacca atacggcacc caccgaatca aaggaagcaa cagtcgtcaa ggacagcatg 2660641 cccatttgca cgtaatgaat gagcaaaacc ggtattccca aggctaaagc catttgagga 2660701 tcaaacgaag cgattttaaa ctccttatag cacacactga tcaacactac gtttaaaacc 2660761 agaacagatg ccagcatcca aaacgctttc ggcccaatat caaccccgaa taccgtcacc 2660821 gtattccacg gcacaaaagc gatttctccc attaacgagt gctcaatatc gagatggaca 2660881 ttcgctccat acacagaaag caaaataacc ccgattgcaa ataaggatgt aaacacaact 2660941 cctatggcag catctgattg aacccccttg ctatgaagaa gctgaaccaa gaaagccgtt 2661001 aacagaccgg ttgcggctgc gccaataaac atataaatcc catcgagact tcccgtcact 2661061 agaaaagcgc cgacaatgcc aagcaacact gtgtgactga ttgcgtcggc cagcatcgcc 2661121 atgcttctca gcacaagaaa tgtgccgatc aatccgcagc ttacaccgac taatacaccg 2661181 gtagctataa tccatgcttc aaaactcatt tgcgatctgt cccttctcgg catcatgaga 2661241 cgcttttcga cgctcaggca tccgtccata cagctttaag agtgaataaa gccgctctct 2661301 cgtttctctc ggtaaacggt ccgggtcaaa gtagtcctga tcggattcta tattggcaag 2661361 ttccatttca tgcatgagat acacttcata catccgctgc ttcaaagctg tgtgatagcc 2661421 tttttctatc cctttgcttg tgatttgcca aatcccattt tcgatacgct caatgcacct 2661481 ctcttgttcc aagtcattta atgccttaag gcataatgaa ggggataggc gtcttttctt 2661541 tcttacactt tcaacagtta cacaaagatt attcttttca tactgttcat aaatcgccaa 2661601 aagcacttgc tccctgcttg ttctgcgccg cagcctcatc agccttatgg ctttagcagc 2661661 caatccccgc ttaggcgcgc aaatcattga aaaaagaaag agcagcgttg cagataagat 2661721 cattaatggc cctgtcgcca ttcccttcat cgtggtgcta agcagggttc cggccactcc 2661781 gctgaccccg cctgtaatcc cggcaatgat gatcatcccg gttaatcgtt cggtccaata 2661841 tctcgcggtt atggcaggtg taatcagcat agccgccatt aatatcacac caacagtctg 2661901 aagcccaatg acgacagcac agacaatcag acaagccaaa agcccgttta aaaaacgcac 2661961 cgggattcct aatccctttg caaacgcgag atcaaaagta atcaatgtaa attccttaaa 2662021 gaaaacaata cataggagca gtagaacagc ggatatccct gcaataagga tgatatcctg 2662081 cctgaccaat gaagcagcct ggccgaataa aaaagaatca agcccgcttt ggcttcccgc 2662141 cccctgttgc tgaatatatg tcagcagaat gatcccgacg ccaaaaaaca cagaaagaac 2662201 aatcccgatc gccgagtcct cctttgtttt tgaaagccga ggaatcagct gaatacaaaa 2662261 cgttccgagc agtccggcga gcgctgcccc cagcaaaaag aaaggcagtg atttttgccc 2662321 ggtgaacaga aaagcgagac acactcccgg cagagctgaa tgggccatcg catcgccgat 2662381 taaactttgc tttctcagca gcacaaagct gcccaaaaca ccgcttgccg tcccgagcaa 2662441 aagcgtaccg gccagcaccc actgtgtatt cggatgctga agctgcagcc acaaactttc 2662501 aaacattgcg ctcactcctt atgtccttct gccagcactt tatcttttaa aaacgtaagc 2662561 cttcctccat atgttttttg caggttttcg atcgtaaaaa cgttttccgt cggtccgaaa 2662621 gcgattttcc ttaaatgaag cagtaagatc caatcgaaat aatcctcggc ggtctgcaga 2662681 tcatgatgga cgacaagcac ggtttttcct ttttctttga gttctgccaa cagcgtcata 2662741 atcgcgcgct ccgtcgctgc atcaacacct gcaaacggtt catccataaa ataaatgtca 2662801 gcgttctggc agagtgcccg ggcaagaaac acccgctgct gctgtccgcc tgacagctgg 2662861 ctgatttgcc ttttcgcata atcatgcatc ccgacttttg ttaatgcggc cttcgccatc 2662921 tccacatccg ctttctttgg cctctttaat aaaccgattc tcccgtatct tcccattagg 2662981 acgacatcga gcgggcttgt ggggaaatcc cagtcaaccg agccgcgctg cggaacatat 2663041 ccgattctgg tccgctgatc cttatagtct ttgccgtaaa tagagatgtc tccggaagct 2663101 ctgggcacaa gaccgagaat cgttttgatc aaggttgatt ttcccgcgcc gtttgggccg 2663161 ataatgccaa taagttttcc ttcaggcacc tgcagcgaaa tgtcctgcag tacaggcttt 2663221 ttatgataag caaccgtcac attatcaagc tcaacaggga acatatcctc cacctctttt 2663281 ctttatttaa gcgctttagt aatcgtgttg atattgtggc ggaacattcc ttcgtatgtg 2663341 ccttcttttg tgcccttttc acccatggca tccgaataaa gctgaccgcc gattgtgact 2663401 gtatggcctt tttctttagc gccttccacc actgcattga ttgatttttc agatacactg 2663461 ctttctacga acacagcttt tatttgtttt tctgtcagaa gatcaaccag ctcctgaaca 2663521 tcccttaatc catagtccga atctgtgctg agtccctgca ggccttttac cttaaatcca 2663581 tactcattcc caaagtacgc aaacgcatca tgagcagtca caagcacacg gcttttctcc 2663641 ggaatatgtg cgatctcctt acgcgaccac ttatctaaat attgcaaatc ttctttgtac 2663701 tctttggcat ttttccgaaa ggcatctgcg tgctgaggca ttgctttgct gaattgcgct 2663761 tcaatttcat ccaccgcata gatccataac ggaatgctga accagacgtg gggatcaaac 2663821 gtcttgcctt cccccgcggg aataagctta tttttcggaa tggcctcagc tactgccgcc 2663881 gattgttttt gttcgccgat tttttggagg acatcctcca ttttcccttc caaatgcaac 2663941 ccgctgtaca gaacaacatc ggcagacatt aattttttcg tgtcaccttg ggaagctttg 2664001 taaaggtgcg gatcaacccc cggtcccatt aaagaggtga cttttacgtg cttacctccg 2664061 atgttttctg ctgcatcggc aatttgagat gttgtcgctg tcacttgtaa ttgctgatca 2664121 gcgctttttc cggctgaatc cgttccgcat cccgttaaag caaaggtcgc aaaaagtact 2664181 gctgccatca gcccttgtct catatttctc ctcctctttg ccatcaatgt ccgattgttt 2664241 tatcttatgt tgtcagttct tagacatgtg acattaaatt agccaaaagc atgttttatt 2664301 tacacaggac aaaaagtttc cctcatgcaa aattatcgcg tttggccatt tttgtcaagc 2664361 tgatttacat aaaaaaaccg gctgggtcag cagccggtcc aaacgagaag ggatgtattc 2664421 aacgaacact tttactgtaa cagcacagtg tcatttattc aaaatagcaa aatgcttttt 2664481 tcttaaccat gctgtgtgaa aacatccatt ttggtcacat attttcgcat aatatcttgg 2664541 tttacctcaa cccctaaacc aggctgtttt gacacagaaa taaatccatt atcaatacga 2664601 atatcaggag ttacaatatc ttcatcccaa tagcgtgagg atgaagatat atcgccaggt 2664661 attgtgaatt gaggcagtga agcaagcgcc acgttctgcg ctcttgatat gcctgtttcc 2664721 agcattcctc cgcaccaaac ctgcatatga tgctctttgc ataaatcatg aatttttaag 2664781 gcttctgtta agccgccgac acgagaaggt tttatattaa taattttgca gcttcctagc 2664841 tcaatcgccc gtctcgcatc atcaactgaa caaatgctct catcaaggca aatggccgtt 2664901 ttcaaatgtt tctgcaagtg gcggtggtca acgatatcgt cagcttggag cggctgctca 2664961 atcatcatta aatgatagtc atcaagctcc tttaaacggc tgatatcctt cagttcgtaa 2665021 gaggaattgg catcggccat aagcgggatg gttgggaatc ggctgcggat ggccttgacc 2665081 aattccacat cctgcccagg ctgaatttta atttttattc tttgataacc ttctttttga 2665141 tagctctcaa tttccttcag catatcgtca agaggcgcca ggccgactac caccccggca 2665201 gggactttat ctcttgttcc gcccaatgcc tcagcaaggg atacgccctt ctttttggca 2665261 taaatatccc atacagccga ttcaagtccc gcttttgcca tccggtttcc tttataccgc 2665321 gccaggctgt ccggcacttc tgaagggtga ttgaattcac ggccgacgac atttgggata 2665381 aaaaaatctt ttagcatatg caaacatgtt ccaatggttt cctcggtgta ccaaggcgaa 2665441 gagaaagcgg aaacttctcc ccagcctgtg acacctgatg tatcaatggc ttccacgatc 2665501 agaaatttac gctcttgaag cgtttcgata ctgtttttaa acggtttctt taagttcatg 2665561 ctcaaatggt aaagcgtgat tttttctatt tcgatcatag cagttctcct ttacgcgcat 2665621 ccttcagctg atttcgcaag agcttattag acgcattgcg cggcaggcgg tcaagcacaa 2665681 agaattttgc cggaatttta tacttcgcca agcgttcttt gcagtagtca gtcaattctc 2665741 ctgcgctcac aggcttgtga aggacaagat aggcgtgagg cactttcccc cattttttgt 2665801 cctcagcccc tgaaaccccg gcttcggcca cagcggggtg tgaaagcagc actgactcca 2665861 cttcggccgg ataaatgttt tctccgccgg atatgatcag atctgaacgt ctgtctaata 2665921 catataaaaa gccttcattg tccaaataac caagatcacc tgttttcagc cagccatttt 2665981 gaaaggaggc ttcgtttgcg ctctcccggt taaaatagct tttcatgaca ttcgggcctt 2666041 tgaccatgat ttcaccgtgt tcatacggtt cacatacctg tccgtcccgc tctattttga 2666101 tttcacacga aaacagcggt ttccccgcag atccgagctt ttccatgctg aattccggcg 2666161 acagggtaac aatttgcgag catgtttctg tcattccata tgactgaaag acagggaatc 2666221 ctttctcacg gcattcctca agcaatggca gcggtgcagg accgccgccg agaagaatgc 2666281 atctgatgga ttcagggcag cggtttgttt cttccaaaag actggccagc atagtctgca 2666341 ccgcagatat cattgtcact tcatgcctgt tgatagaatg cagcacatcg cttacggaaa 2666401 aacgctggtg aagcacgaca gtcattccat agatcacaga tttaaataat gcggacaatc 2666461 cgctgatatg aaagagcggc aatgcgataa gccagcggtc ttgttctgtt atacccaaat 2666521 taagagcgga cgacaccgca ctgaaataat ggtttccgaa cgtttgctga actcccttgg 2666581 gctttcctgt cgtacccgac gtatacatca gcgttgccgt tgcatccatt tgcatataag 2666641 cctcgatctc aatttcctct gctgcttctt tcatcagttc atccacatca atcgtttgaa 2666701 cgatgtgttc atattctttc ttctcaaagc ttgaatctgt caataaaaag ccggatcccg 2666761 aatcctccag ctgaaacagc ctttcatgtg ttgacagctt cgtattcaaa agcaccgcct 2666821 taacaccaag caaaaaacaa gcgtgaacag cgtataccat ttctgcacgg ttttggagca 2666881 aaatagctgc agtatcccct ttccgaaccg aatgagcggc aagctgttcc gccattcgtt 2666941 tagacgcggc aaacaattct gcaaatgtca cggtttggtc ttcatagatg agagcgattc 2667001 tctcaggtgt cagctgtgcc cgctgcatga gccagttggg ctgttctgtc agcatgtcat 2667061 catctccgag gtaaaatgtc tgtattgaaa agaaaacagc ttggaccgca aagtctcaag 2667121 ctgttggttt actagatatt gctgatcacg gaaaacgagg gaactgtccg aaatcaggtt 2667181 tgcgtttttc cttaaaggaa tcacggcctt cttttgcttc atctgttgtg tagtaaagaa 2667241 gggtagcatc ccctgcaaac tgctgaattc cagcaagtcc gtctgtgtcc gcgttaaacg 2667301 cagctttaag aaagcgcagt gcggtcgggc ttttttcaag catttcttca caccatttaa 2667361 tcgtttcttc ttcaagctgt tccaaaggaa cgactgtgtt gacaagaccc atgtccagtg 2667421 cttcctgtgc gttgtactga cggcataggt accagatttc acgtgctttt ttatgtccta 2667481 caattcgagc caggtagcca gaaccgtaac ctgcatcgaa gcttcccact ttagggcctg 2667541 tttgtccaaa aattgcgttg tccgcagcaa ttgtcaagtc acatacgatg tgaagcacat 2667601 ggcctccgcc gatcgcatat ccggacacca tcgcaacaac cggtttcggg atgacgcgga 2667661 ttaaacgctg aagatccaat acgttaagac gagggatctg gtcgtctcct acatatccac 2667721 cgtggccgcg cactttttgg tctccgccag aacaaaatgc tttgtcccct gcaccggcaa 2667781 gcacgataac cccaacgttt tggtcgtctc ttgcgtcagc aaacgcatca atcatttcag 2667841 caaccgtttt aggggtaaac gcattatgta cctcaggtcg gttgattgtt atttttgcaa 2667901 tgccattata cgtttcatac aatatctcat cgtatgtccg ttttgttttc cattcagcca 2667961 tatgatgacc tccttttatt ctctatgtga atgagtcaga tgcttgtcaa aaactcactc 2668021 actattttac caaacaatcg cggctgctcc acatggaccg tatgtcctgc ttttggaaca 2668081 atctctattc tactagaagg aagcatctta tgcacctctt gattgatggc gcaaaatttt 2668141 tcgtcccact ccccgcagat cagaagcaca ggaacatcta tttcctctac acggctccac 2668201 aaggaaggct gtgaaccggt gcccatgccg gttaaactgt tcgcaagccc aatcttattg 2668261 ttccgcagac ggcccgatcg tatcctgtac cgaatatctt cagccagcct ctgctgagat 2668321 gaaaacaaag ggatattctc ccaatacgca acaaacgctt cgagcccgtc tcgtaaaata 2668381 aaatcagcaa gcttccggtc ccgcatgatt cgttcccgcc gttccccaag tgttttgagc 2668441 cccggcgtcg tgctttcaag cacaagtgcc gatacccgct cgggatatgt catcgcaaaa 2668501 gagtaagcaa gccttcctcc catagaatac ccaatcaatt tcactttgtg aagttttaat 2668561 tgatcaaaaa tctcggcaag gtcagaaact tgccgggttg tgctgtatct tttcccattc 2668621 agcggggcat cggtttcccc atgccctaaa caatcaattt tgatcaaacg ggaatcaggc 2668681 agcatttcat caagaaaagt ccatgattgt ttgctgccgg taaacccatg cagacagacg 2668741 acggcttcgg aagcattcgg tccctcgtct gccactgcat atcggacacc atctgatacc 2668801 gttatgttta cagttcccat tgttttttca cttcccgcac agcctcattc agcatatcgc 2668861 gatgaagctg gactcttgat tggcgatccg ttttgatttc aatcaaatgg agtccgggct 2668921 tgtctgcctg cggcgcgtaa gctgttttga attcatccca agaagccggg catgaatacg 2668981 ttccgccgta aagtgcagcc gcatgcttga aatcgagccc tgtcggtgtg ccgaacaaat 2669041 cttcaaagtg tgtcttctca gaagcctgcg gcaaaaagga gaaaatccct cctccgtcat 2669101 tattgacaag aatcacagta agaggaatac ccagcttttt ggccgccagc aggccgttta 2669161 aatcatgata aaaagataaa tctccaatca caagggtaac aggcgctttt gttccttcac 2669221 atacccccat ggcagaggag acgacaccgt ctatcccgtt tgctccccgg tttgaataaa 2669281 tccggaaagg gcggtcctgc ttttcaaaaa acgtatcaac atccctgatc ggcatgctgt 2669341 ttcccacaaa cagcgagctg ttttcaggca caagatgctg aaggattcga tagagattgc 2669401 cttcaaacga aacatcttca ctgctgattg tttgcagatg ctcgcggaac cgcccattga 2669461 caaactgcca cttttccagc cactctgagg atctggtggc agcagtaagg cctgccatga 2669521 tctcctcagc aaaaacagac gcattacaat gaatcatatg cgcgcttgcc tgtgtcgggt 2669581 ctctccaccc tccatcctcg tcaatcacga tttgctgaat cgtcggatca tccttaagcc 2669641 ataagaaaac cggttttgaa acaggcatcg gtccaaaccg aatgacaaca tcaggacgga 2669701 gtttccgctt cagctcatca tcttttaaaa acgaatcata cgcatcaata acagtgcttt 2669761 tatcatgaac accattccgc agattagaca gcggatctgc taaaattgga tactgaagcg 2669821 cttttgacag cgcaataatg ttttccttgt ccgcatcact atggagctct ccgcagacga 2669881 tcattccttt ttcagcctct gcgagcatct cagccacatc agacagggac tctcggtcaa 2669941 cagactgcgt acccgttttc acagacacat gacggcctgt tctcattctt ccaaacggct 2670001 catctgaaag atccggcatc agcggttcgc gcagcggcac attcacatgg acaggcccca 2670061 tcgggcgctt ttgtgcttct ccggcagcgc ggcttgccag cgttcggatg tatctcagca 2670121 tttgcggaga ctcttcagga agagcagagt ctgtgaaaaa cttaacaaag ttaccgaata 2670181 agaagtgctg attaatagcc tgcggtgcgc ctacttcgcg cagctcatga ggccgatcag 2670241 cagttaacac aataataggc acccttgaat aatgggcttc aaccacagcc ggataaaagt 2670301 tggccgcggc tgttccagat gtacagatca atagtacggg acgctgcttc gcttttgcca 2670361 aacctaatgc aaaaaatccg gcagaccttt catcaatttg gacatggacg ctgatatcgg 2670421 gatgcgcagc acaaagaaca gccagcggtg tagatcttga gcccggacaa acgacggcgt 2670481 ccgtaattcc ggaaagggcg aattcatcaa taaaacttcc gatgtaatga gtaatcgggt 2670541 tgactgtcaa cgcctctcac ctcctaatgc agagatcatc ggcttcaatt taatctgtgt 2670601 ttcttcatat tccgagattg gttccgagtc ttccacaata ccgcacccgg caaacagcct 2670661 tgctgtgctt ccttcgatga gccctgaacg aatggcgacc gcgaattccc cgttatcctg 2670721 gctgtcaatc cagccgatag gggccgcata ccagccgcgg gacatcggtt caatctccct 2670781 gatcacgtca acagcttttt cctgaggtga tcccccaagc gcgggagtgg ggtgcagctt 2670841 ctcaattaag tcaaaaatcg aagcagactc gcgcagctgt ccgacaatcg gcgtaaacag 2670901 gtgctgaacg ctttttgttt tgtacaaaac aggtccatca ggcttttcaa cctctgaaca 2670961 gcttgataca aaagcattat gaatcatacc taccacaata tcatgctcaa gcaggttttt 2671021 ctcatcgttt aataattcaa ggcctatccg gcggtcgtct tcttcattca cgcctcgttt 2671081 aatggagcct gccagacagg aagacatgac agtgccgccg tctcttttga tcagtctttc 2671141 cggagacgcg ccgacaaagg ttttgccttc ttgttcaatt gcaaaaacat agcttgtctg 2671201 ctgatcgtcc agaagcgttt taagcaccgg ttcaatttgg attggaccgt caaacgtgag 2671261 cagcagctct cgggcaagaa caaccttatc atattgtttc tctttaattt ggcttgtggc 2671321 cgtttcgatt gctttcagcc aatcatcctt atccagctct tcggctgctg caatcacagc 2671381 ctgatcttct tgcttgaaat cgggaaccat aaattccgcc gcaaaagctt ttaagccttc 2671441 taaaacagct tctgcgtctt ctcctccgct tacccatctg ttaactgtta agaacgggcc 2671501 ttcagcagtc atcgtcagca taagcgcagg cacaaagaaa tccccttccg agaaatggtc 2671561 ccattgtgaa cctctttctt cgcaagggtc aaaagaaaat cctccgaata acacaggtcc 2671621 cactgcagaa tgctgcagct tttcttcttc ataaatatga aaagccgtct ttttaaagcg 2671681 ctcccattgt tcaaaaacct cacgataccg ctcgctgttt ttttgatttg tctggaaaac 2671741 cgcttctttg ccaagaccga ctattgtcaa ttcactttca ggatctgacc aaaaaaatcg 2671801 attgcctgta tatttttttg ctccgtaatt gaaaaatgat agagggtcaa gagactcgat 2671861 ttgtctcgaa tagcttatta agacagcatg gttgacttct ttggctttat gtaatgcatg 2671921 tagaacttcc tttcggaacg tacgctgcac cgttgtcacc atgagacatt cctccataat 2671981 ccttaaaatg cttttaatac catacacctg tgtctccttt gtgtcaaaca cagatcatgc 2672041 agtccaaatg gcctgcctta cctattataa acctaatttc agaaatgaaa aagaaacaaa 2672101 gcttaaattt ctttctccac tgatagcaaa ggttgtatcc gcttaccata aaaggaaaac 2672161 ctcctatatt cctccacccg ccatttatga aagttctcag gcgatctgtt catactaaag 2672221 gtatgcatca cagagaaacg aggcgatcac attgcttacg aaagaacagc ttcagcattt 2672281 aaaaaatgaa ctggaacaaa cgaaaaaaga tatcttaaac cgtttcaaag acaatgatca 2672341 ttttcagctt aactcagcct ttccttatga ttcgtggggt gagctttcgg catacgacaa 2672401 ccatcccggc gatcaggcga cagaacttta cgagcgtgag aaagacatcg ctctagactt 2672461 gcatgagaga gagcaccttc gggacattga gcattcattg aaggcgatag aaaacggtac 2672521 gtatggcatt tgtgaagtca gcggaaagga aatccctttc gaacgacttg aagcgcttcc 2672581 gactgccaca accctcgcgg agtattcgtc acaggacgtg gtttccaaag accgtccgat 2672641 tgaagaagaa acaccattcg ggcaatttga atttgatgat gatgaagaaa tcagagcgcc 2672701 atatgacagt gaggattcct atcaggatgt cgaaaaatat gggaactcac aaacgccgca 2672761 ggatatggaa aaccctccgc tcagctatga tgatatgacg atgaatgccg aagagaatat 2672821 cggcaatacg gagtcttacg aaaatttcat cgctacagat atcactggga aagaaattac 2672881 cgtttatcaa agcagagccc atgagcgcta tgaagaagaa cttgacgaag agggaatcat 2672941 gaccacattc ggcgatctcc acgctgattg aacccccaat tattgggggt tcttttccgt 2673001 tttcagcata tcgtaaatca gcttcagata atccttttgc aggccgatgt cataccgctc 2673061 gccctctagc aatttcccgt atacggtaca tgccccgagc gaagctttta tcgcatccgt 2673121 tacctgcact tctcctccgc tatcagcttc taatgcctcc agctcattaa aaatatccgg 2673181 tgtgaaaata taacgccctg ctgcggcaaa atgagacgga gggttttgtt taggcttttc 2673241 cacaatatcc tgtatgcgat aaagcccttt ttcaacaggc tcccctttta tcaccccgta 2673301 atgatgtaaa tcctccgttt ttgtttcttt taagccgatc acactggact gatatttcgt 2673361 atacgcttca atcagctgcc ccaaagccgg ctgattggcg gaaaaaatca gatcatctgg 2673421 caaaacgacg gcaaaaggct ctcctcctgc aaattgcttt ccgaaagaaa tggcgtcgcc 2673481 aagacccttt gcataaggct gccgcacata gtgaatccgt atatccggaa tgggatgctc 2673541 tctaagtaaa tgcagtttat tcttagaggc caaaaaagcc tcaagtgcca aagaggaatc 2673601 aaaatagtcg acaatcagat ttttatggct cgatacaacc atcaaaatgt cctcaatgcc 2673661 tgactccttt aattcttcaa caagataatg aatcacaggc ttagatccta ccggaaacat 2673721 ttctttcgga atcaccttcg tcaccggcag atttctcgtg ccgaatccgc ctgcaggaat 2673781 gatcgctttt tttatcatgg tattttcccc tcagctcatg tttattacat gatattccaa 2673841 gagcgcatcc cgatgtttgt acatctgaaa ttaggcggaa gcaactgggc agaaagcgga 2673901 atcacgaacc agcccttttt taataggata ttgatatatg accagtaatc ttgtaaagga 2673961 gctcaggtga tgaaaatttg tgtggttggc gccgggtatg tcggtttaac cctatcagcg 2674021 gcactggcat ccatcggaca tgacatgata tgcacagaca aagacgtcaa aaaaatcggg 2674081 cagctgaaaa aaggagtcat tcccttttac gagcctgggc tttcagatgc aatacttcgt 2674141 tgcggcaatc tctcgttttc ttctgaagtg aaatcgagca tggaggaatg tcccgttatt 2674201 tttatcgcag tcggaactcc gccgcgttcg gacggatcag ctgatacgaa agccctgcag 2674261 tccgtcatcg gtgatttaag cgaggcgatc cgatcgtata aaaccattat tacgaaaagc 2674321 actgttccgc ccgggacaaa tgaaaacata gcaaaacagc tgattgcctc cggagtgtct 2674381 aaaaacctct ttaatatcgt atccaatccg gagtttctgc gggaaggcaa tgccttatat 2674441 gacatgctgc atcctgacaa aacagtcatc ggtgttcagg aagaagatca cgtatcggca 2674501 gccatcgtca aatccattta caaacacatt gatacccctt ttatcgttac aagcttagcg 2674561 ggagcagagc tgatcaaata tgccaacaat ttctttttag cggccaaaat ttcgttcatt 2674621 aacgaaatgg cccgcatatg tgaagcctat caatcagata tctcagatat ttcccgcgct 2674681 atcggtctag acccaaggat cgggaagcac tttttgcagg caggcatcgg atacggaggc 2674741 tcttgttttc caaaggatct gcaggcgctg caatttgctg cccaggaaaa aaacacggag 2674801 accttcctgc tccgggccgt gcagcacatt aatgacaccc agcttggcct gtatatcaaa 2674861 aaaatacagt cattcttcga aacacttcaa ggcaagaaag cggctgtact cggcatttcc 2674921 ttcaaaccga atactgatga catccggaat tctcaggctg tcagactgat ggaaaggctg 2674981 gcggagctgg gatgtgatgt tcatgcatat gatcctgaag ctgtacttcc agaacatttg 2675041 cggcaacatg taactcagca ttctcaagct tttgatgcga tcgaagagag tgacttttta 2675101 tttttggcga cagaatggtc tgagttttta gcgtttgatt ggaaaaaggc tgcagatatc 2675161 atgaaagggc gtcttgtgat tgacggacgc aacgtactaa aaaaagaact gatcgaggct 2675221 tgcggcctga tctgtacggg agttggccgt ccatgaaaat actcgtcaca ggagcagcgg 2675281 gctttatcgg ctcccacctc tgcgaagaat tactaaaaga taagaaacat aacgttatcg 2675341 gaatcgatga ctttatcggt cctactccat tttccttgaa attaaaaaac cttaaaaacc 2675401 tgctgccgga aaagcgattt acgttcataa aggaaaatct gctgacagcc gatcttgctt 2675461 ccttactgga aggagtggac gtcatctttc atttggcggc cataccgggt gtccgctcaa 2675521 gctggggcaa tcattttcac ccatatgccg cacataatat ccaagcgctc caaaggctcc 2675581 tcgaggcgtg ccgggaacat tctattcaaa cgttcgtctt tgcatccacc tcttccgtct 2675641 atggcgaaaa acaaggaaaa gtcagcgaaa acacgtcgct ttctccttta tctccgtacg 2675701 gggtaacaaa gcttacggga gaaaagcttt gccatgtgta taaacagagc tttggcattc 2675761 caattgtgat tctccgtttt tttaccgtat acgggccaag acagcggccg gatatggctt 2675821 ttcaccggct cattaagcag caccttcagc aaaagccgct taccatcttc ggtgatgggc 2675881 agcagtcaag agatttcact tatatcagcg actgtgtcaa aggcatcacc gctgttcttg 2675941 ggaaacccca ccttattggt gaaacagtaa atatcggcgg cgcagagcgt gcctcagtct 2676001 taaaagttgt ctccctcatt gaggatattt ccgggagaaa agcaacactg cacttttcgg 2676061 acaaaatagc aggggaaccg agcaacacgt gggcggatat ttcaaaagca aaacagctct 2676121 tgcattatga tcccgccaca tccttaaagg atggcttgac caacgaaatc gcctatttat 2676181 cgtcgctgta tcagggggaa taaaaatgaa gcttgccttt atctgtacag aaaagctgcc 2676241 ggcgcccgca gtacgcggcg gcgctattca aatgatgatt gacggtgtca cgccctattt 2676301 cagcagcagg tacgacctga ccattttttc aatagaagat ccatcgctcc caaaaagaga 2676361 aacaaaagac ggcgtacatt atatccatct gccaaaagaa cattaccgcg aggcggtagc 2676421 cgaagagctg cgagcctctt cctttgacct cattcatgtg ttcaacaggc ctttaaatgt 2676481 ctctttatat aaaaaagcct caccaaacag caagatcgtt ctgagcctgc ataacgaaat 2676541 gttttctgaa aaaaagatga ccttcgcgca aggaaaagaa gtactcgaca atgtctccat 2676601 gatcacaaca gtgagcgaat ttattaaaca aaccgtcatt gaacgtttcc ctgaagccga 2676661 ggacatcaca aaagttgtgt attccggcgt tgatttaaac tcttatccgc ccgtctggac 2676721 gatgaaaggc tcggctgtca gaaaaacata ccggaaaaaa tacggtattg aagataaaaa 2676781 agttatttta ttcgccggcc gcttaagccc gacaaaaggg cctcaccttc tcattcacag 2676841 catgagacgg attttgcagc agcaccctga tgctgtactg gtcatagcag gcgggaagtg 2676901 gttcagcgat gacagcgaaa accaatatgt cacctatctg cgcacgctgg cgctgccata 2676961 cagagaccac ataatcttta caaaattcat tcccgcagac gatatcccaa acctttttct 2677021 gatggcagat gtatttgtgt gcagctctca gtggaacgaa cccctcgccc gtgtgaatta 2677081 tgaagcaatg gcggccggca cgcccttaat taccacaaac cggggcggaa acggtgaagt 2677141 cgtaaaacac gaagtcaccg gccttgtcat cgatagctac aacaaacctt cttcatttgc 2677201 aaaagcaatt gacagagcct ttacagatca agaattaatg aacaaaatga caaaaaacgc 2677261 ccgaaagcat gtagaagctt tatttacctt tacccatgct gccaaaaggc tcaatactgt 2677321 ttaccaatcc gttctgaccc cgaaaaacaa acaatttccg ccgccttttc tgacgcaaaa 2677381 ttttgattta tcatctatca atcagctttt tgtgaaagca aaaacataaa acctacagct 2677441 cgtgttgcaa aacgggctgt tttttcgcta cagagaactt aaaaaaaggc ataaatgtga 2677501 ctttatgcct tgcgctttac agtttgagaa aaccatggag ctggtttaga ttcacttgga 2677561 agaatgatga tttccacttt agcttcttcc gctaagtctg gttcttcatc ttcatcctct 2677621 tcttcatatg ggggcgctga gcgtttcgaa tcacgctcct cctcaggctc cagagtggtt 2677681 tcgaattttg tttcttcttc atcatcgacg attttgcgat ctgtttcctt ttccttcgtt 2677741 tctttttgat attctttcgg tgcattgatg tgagggagct ctcgaatgct gcccacatct 2677801 aaatgcttct cctcttcttc cttctcagct gagattgagt catgagcctg ccatcccatc 2677861 ggtccaggcg gtgtaaatac gaattggtcg agatccagtt tagaaataga ggctttttgt 2677921 ctcgatgacc tcatgtcaat tcgcctcccg atacgctttt atctttttat acagttccgg 2677981 cagtttatcc aaaaacgaat ctttagattc ttcaacagaa atcatgtttt gcagcgccca 2678041 gttatacttc tcatctgacc acgttttctt ttgcttcaaa taatatttgt gcccgattgc 2678101 acagaacaaa tgcggaaacg cgagatcaat ccaaagtacc tcgtactgtt tttctgtgag 2678161 cggatacact gcgtcgtagg ccgcaagcag tgcaaccatg aaatcagtat cccatacaga 2678221 aagcttaacc atcactttat tcagcagaat acgaaggtct cttgacggca aatcgtaggt 2678281 aatcgagtga agctccttta aaaaaggctc cccttcgatc tcagtcaaac gtgccaatgt 2678341 aaaatcctga aaacagaatc cgccatgctc gagtgtctct tttgtccagg tttcgtattc 2678401 tgagtcatca agcgctctga gagcttcttt tcctcttgcc agcattttat cagcatgttt 2678461 taagaaagtt tgcgaaaata cgtcatcagg ataggatgct gcgatctgca tattcccttc 2678521 aagttcctgc agcttccaac ggtacaattt gtgccatttt cccagcctgc ttctcttctt 2678581 gctttcatct gtgcaaacat atccttttga ggcatgatga aaatggccgg caaatgacat 2678641 gacttttttc atttgctctg catcatagta aatcatttct tttcctgtca ctttgtcata 2678701 taaactgtaa gaaacctgat ccgtgcccaa gcagctaccg ccattttttg tttgatgaat 2678761 cggcgctatc ggcagccctt tctcttgtaa atgggcgtgt gcctgagtga taaaaagcat 2678821 ccgctccggt ttcatttgcg cttcttttag cagctttggg ccatgatcag tttcgacttc 2678881 ccagattttg cgcccgcttt tgttcgattt cagcgccaca tggtcgatat gaaacggata 2678941 ataactgaga atttcggaca caatctgttc ttcatgctct ttttggtaca ctctgttcac 2679001 cccttctatc tgttcttttc atagacgctg agcagatttt cagccaccct ctgccagcca 2679061 aaattgcttt ctgcctcacg gcggctgtat ttcccaagcc gttcccgctt ttccgagctg 2679121 ctcagcaaat cattgatacg ttcggcatat tgtttaggat tttcaaagtc atgaatgatg 2679181 tagccgtttt tcccttcctc tatgacctct ggattgcctc cccgattgct tgtaataata 2679241 ggaagtcccg cagccatcgc ttcataatgc acccttgcta aaggctcctg ccattgcgaa 2679301 gagcatacaa atacatctga catggtataa aggcgcggaa tgtcctttgg cttcacaaat 2679361 tgaataaatg tgacatgatc cttttgcatc gcaccaaggg tatgaagatg tttgacatag 2679421 ttatttaatt cattatctcc gaaccatttt gacccgataa acaccatcat gacatcgggg 2679481 tgctcctcaa tgatgtccgg caaagcctgc aataatatgt gcgggccttt gactttgcta 2679541 agccggccga caaacaagac gatttttttg ccgtgaagcc ccagctcgct tcgcatctct 2679601 tcgcgagctc gctgcccttc attcgtccag cgagggtggt acgtttttaa atccacacca 2679661 gaatacaccg tttttgtttt tgatcgtgct gacggaaaac ggcttgtgat cgtctgtccg 2679721 atataatcgc tgaccgtaac aatctgcgct acggagtcga tgcaaatctc gccttccgcc 2679781 tggctgattt tatcgtaagc gaacatttca ttgtgaacgc ttaaaataaa aacagcatcc 2679841 ggcgcctgtt tcttcaattt cggaacccag cttgggcgat tacaaacatg cacaagatca 2679901 aaacggctct ttttcagctc tgctccaacg gcttcttcat aacggtcttc atccaaatgc 2679961 acataatgga caccgtctac cttctctcta tcagcgagat tcggatcttt aatagaaaac 2680021 acagtcacct catgtttttt tgcaattaaa ggggcaaccg cttcgaggta gatttgaatg 2680081 gcgcctcctc gaaccgatgg gacaggaagc ttctctgtgg cgatcagtgc tattttcata 2680141 catagcctcc attcctgcat gatttttaac tagttagaat catgatacgg ctgaacaacc 2680201 aacttgtgcg gaatgggact gccctaaaaa caaaacgggt aaacaaccag attcatctat 2680261 taaatatagt caaataactc aatcattttt tccttttgat tcataaggta ggagtaaaac 2680321 aggtaaggat gtgtccttta atggcagaaa accatgaagt cattgaggag gggaattcat 2680381 cagagcttcc tttatcagca gaagatgcaa aaaaattaac ggagctggct gaaaatgtgc 2680441 ttcaaggatg ggatgtgcag gctgaaaaaa tagacgtcat tcagggaaac cagatggcgc 2680501 ttgtctggaa ggtccacaca gactccggcg cggtttgtct aaaacgaata cacaggccag 2680561 aaaagaaagc gttgttttcc attttcgcgc aggactattt agcaaaaaaa ggcatgaatg 2680621 ttcctggcat actcccaaac aaaaaaggca gcctatattc taagcacggc tcatttctat 2680681 ttgtcgtata tgactggatc gaaggaagac cgtttgagct gactgtaaag caggacttgg 2680741 agtttatcat gaaaggcctt gctgattttc atacagcttc cgtcggatat cagccgccaa 2680801 atggcgttcc catatttacc aaattaggtc gctggccgaa tcactacacg aaacgatgca 2680861 aacagatgga aacgtggaag ctgatggcgg aggcggaaaa agaagatcct ttctcacagc 2680921 tttatcttca ggagatagat ggctttattg aagacgggct gcgcatcaaa gaccggcttt 2680981 tgcaatcgac ctatgttcca tggactgaac agctgaaaaa aagccctaac ctttgccacc 2681041 aggattacgg aaccgggaat acactcttag gagaaaatga acagatttgg gtcatcgact 2681101 tagataccgt atcatttgat ctgcctattc gcgatttgcg caaaatgatt attccgcttt 2681161 tggatacgac gggtgtttgg gatgacgaaa catttaatgt catgctgaac gcatacgaat 2681221 ccagagcccc attaactgaa gaacaaaaac aagtcatgtt tattgatatg ctgtttcctt 2681281 acgagcttta cgatgtcatt cgcgaaaaat acgtccgcaa gtctgcttta ccgaaggaag 2681341 aattagaatc agcttttgaa tatgaacgca ttaaagcaaa cgcattgcgg cagcttattt 2681401 aagaccatca tttcccccgc atatcggggg tttgatattt ataagataaa gggtaattaa 2681461 atacatgcgg aggttgcaaa tatgaaaaag attgtcggcg ctttagccgt ttttgtgatt 2681521 acatatgcgc tgttttcagc cgcaggctac ctgtttcctg tggaccaaga atggtacaat 2681581 tcattgaaaa aaccggactg gacgccaagc ggaactgcga tcggcatcat ttgggccatc 2681641 ctgtttgccc tgatctccct ttcagcagcc attgtatatg ctgcgttttc atttaaaggt 2681701 gcgaaaagct tttggtttac acttttgata aattacgtgc tcaatcaagc cttcagctat 2681761 ttccagttta cgcaaaaaaa tctgctggct gcatcgcttg actgcctgct tgtcgccatc 2681821 acagcaatcg tattactgat cattgccaaa aaatacagca gagccgcaag ctatcttctt 2681881 ttgccttatt ttttatggag tgcatttgcg acgttcttat cctttacaat caattcaatg 2681941 aatctgtgaa caaaaaaagc cgcttataca gcggcttttt cacatcatcg gcttgatgcc 2682001 ccaaatgtcc ttcgcatatt cccggatcgt gcggtcgctg gagaaatatc cagaatgagc 2682061 aatgtttaca atcgaatgct cagaccattt ccttcgctct cgataatcag cttgaattcg 2682121 ctcctgtgca tctgcatatg agctgaaatc cttcagcaca aaatactcat cattatgcgg 2682181 aagcagcgag tcaaagatcg attcaaattc atctgcctct ccttcaaaaa aaccattgat 2682241 caactgatcc gctacctgcc tgattctcct gtcatgctga taatattccc tcgacctata 2682301 gccgccgttt tcctgatacg atagaacctc atccgccttt aagccgaacg tgtaaataca 2682361 gtcagggccc acccgctcaa ggatctcgat atttgcgccg tcatgcgtgc cgatcgtcaa 2682421 agccccgttc atcataaact tcatattccc tgtaccagac gcttccttgc ttgcggttga 2682481 aatttgctca cttacgtctg atgccggaaa aattcgctca gccatagaaa ctctataatt 2682541 ttctaaaaaa acaactttga tcagctgttt gaccgccgga tcataattga ctttttctgc 2682601 gacagaatgg atcagcttaa tgattttctt ggcataataa tagcttggtg aagcctttgc 2682661 cccgaaaata aaggtttgcg ggtagattga aaaccccgaa tcctccttga ggcggttata 2682721 caaatacata atgtgaagaa cattcagcag ctgccgttta tatgcatgaa gccgtttcac 2682781 ctgtacgtcg aatatgctct cagggttcac aaccaccccg gccgtgcaaa aaatcaaatc 2682841 ggcaagctct tgttttttct tgcttttgtt gttttgaaac tgttcaataa atgcaggatc 2682901 agtggcgtac ggttctaaac ggatcagtga ttccggctgc ttgacccatt catcgccgat 2682961 cgcctctgta atgatggcag acaagcctgg attcgctttt aacagccagc gcctgtgggc 2683021 aattccattc gtcttattgt taaaacgatt cggaaacagc aagtgaaagt cgcgcatctc 2683081 cctttccttt aatatatcgg aatgtatttt tgcaacgcca tttacactgt agctgcctac 2683141 tatggccaga tgagccattt tgacaacacc atgcgctgta atcgccatgt tctctatcct 2683201 tttccagtct ccaggatact tttcccaaac tgcacggcaa aacctctcat tgatctcttc 2683261 aataatcatg tacattcgcg ggagcagcgg cttaaacaaa tgaatcggcc atttctcgag 2683321 cgcttctgac aatgttgtat gatttgtata agaaatcgta tgtacagtga tatgccaagc 2683381 ttcttcccag ctcatgttct cttcatcgag caaaatccgc attagctcag gcaccgcaag 2683441 cgcagggtga gtgtcattaa tatgaatgct cactttttta tgcaggccgg ataaagattt 2683501 atgtgtttta cggtaattgt tcacaatgct ttttaagctt gcgcatacta aaaaatactg 2683561 ctgcttcagc cgtaaaattt tcccctcatc atgggtgtca tcgggatata agaattcaga 2683621 aaccgcttct gtttctcgct tataagacaa aatattaccg ccgtgataat gggcataggg 2683681 ctcggcgttc caaagcctta acgtgttgac agtgcccgtt tcatagccga tgatcgggat 2683741 atcataagga acagcggtaa caattgtcgc ttgttcatgg cgaaaatgca ggcgcccgct 2683801 tttttctgtc atatggactt cgccccaaaa cggcacgtcc actgcttgat ccgcattcct 2683861 tacttcccat acgttcccgt ttttcagcca ttgctcaggc agctccacct gatgtccgtc 2683921 tacaattttt tgctcaaaca aaccatgctt ataacgtatg cccatgccgt gcccaggcag 2683981 gttcaacgaa gcaagcgaat ctaaaaagca agcggccaag cgcccaagtc cgccattgcc 2684041 gagacctgca tcgttctcta tctgaaggat ctcctctaaa ttgatgccga tttcctttaa 2684101 accagcttct acaacatcac gaacaccaag attcattaag ttttgctcaa ggagctgacc 2684161 gagcagaaat tcgattgata aataatatgt ctgcttcccg gaatttgatc tgcttttttc 2684221 attcgtttcg atccaatcag cgctgatata ctctctgacc atattgccca acgttttata 2684281 ttgatccagc ttggcagaat ctttaaagct ttttccgcac gtcatttcca gacgctttaa 2684341 aaataagtct gcaaagcgtt ctttactcga gaacatcccg tccactcctt gtcacctgct 2684401 cgaaaatacg ctgatactct ttagccgact tcccccagct gtaatctgca ttcatagcgg 2684461 tcttcacgat gctcttccat acatcctgtt ggcaataaaa cgacagcgcc ctttctatcg 2684521 taaatttcag atcatgcgca ttaaaggcgg aaaacgtaaa gccattgccc gttccctctt 2684581 cctcctgata ggcacggaca gtgtcgtaaa gaccgcccgt ttccctgaca atcggaatgg 2684641 cgccatattg aagagcaatg agctgcccca aaccgcacgg ctcaaatttc gacggcatca 2684701 aaaacatatc agagcccgca taaatttgat gggctagcgg ctcatcaaac ccgatataag 2684761 cccggcactt ctcatgaaaa gcaaattctg cataccggaa ataatcttca aattcacgtt 2684821 ctcctgtgcc tagcacaacc agctgtatgt cttgctcctc aagaagttcg tgcataattc 2684881 tgcggacaag atcaagcccc ttttgtttag tgagccttgt caccatactg atcagcggaa 2684941 tatcgttttt ctctggaagc cccatccgct gctgaagctt cgttttgttt tccagcttgc 2685001 atgcaagatc ccctgaatcg tattgcgcct ctatataagg gtcgcttttc ggctgataga 2685061 acgtatcatc aatgccattt aatatgccgg ttacatcatc ttccctatat tgcaaaacct 2685121 gttccaactg ctcaccataa tacggcgtca tgatttcatt tctgtaagtg gggctcacag 2685181 ttgtcacatg atcagccgca atgatgcccg ctttcataaa attaacaaat ccgttgcatt 2685241 ctaacctttc ataatgaaaa tgatccatct caagacccag caagtcatgt gtgacatcag 2685301 gagggaatat gccttgaaac tgcaggttgt ggatcgtgag cacgcttttc atccgttcat 2685361 aaaaaggatg ttttctgtac tcctctttca gcaaataatt gaccatcgct gtatgccaat 2685421 cgtgagtatg aacaatatcg gcttgaacat tcacaacttt ggcagcctcc agcacagctc 2685481 ttgaaaaaaa ggcaaaccgc tcaccgtcat cataatgccc gtacaacgaa tccctgttga 2685541 aatagtactc attgtcgatg aagtaataat tcacatcatt ctctgccata tgttcaattc 2685601 cgcaatattg ctgccgccag ccgacagcta cggtacactc agcctgtttt ttcatacgct 2685661 ttttccacgg ttcaggtatt tggctgtact tcggcagcat cacagctacc tcattgccta 2685721 atcgcgcaag cgcctttggc agagcacctg ctacatcggc aagacctcct gatttcacaa 2685781 atggggtgca ttctgacaca gcaaataata tcttcaagaa ttcatcagct ctccttgcac 2685841 caaacctttt cttaatacaa gcggctgctc agctgttcct gcagcttccg tcgccttgcc 2685901 gattttaaca tccttatccg aaatgacctg ctcaagaaga caatcctctc caatctgcgt 2685961 tttttgcata ataatgcagt ttttcagctt cgtacccttt ccgacatgga ccgccctgaa 2686021 caaaatgcag ttttcaacct ctccttcaag cacacagccg tttgccacca aagaattttt 2686081 gacagtgctg tgctttccgt atttcgtagg cggctcatcc ttcacttttg tatagatcgg 2686141 ctgctgcggc aaaaacacct gctgccaaaa acgaggctga atgagctcca tactgtgggt 2686201 ataatatttt tccaccgaat caatgacagc ggcataacct gaatattcat aagggcaaat 2686261 ggtcagggcg gaagattcct tttcaacagc ctcctgaatg gttttatagc ctttttcgct 2686321 atgtccgtag atcagatcct ttaaaagcgt tgttgacatg atatagattt gcagcgactg 2686381 gccgtcctga aatacctcgg tgacgtcgca gccaacctcc tgatggcgtt tcagcacata 2686441 ttgaaattga atgttgcata cggtatggct gttggagatt acagcatatt gctgagtgct 2686501 tctgtggaag taatctagat ggtccgaaaa ctggcgaaag gaaccgaatt catcgtattc 2686561 gtgatgaaga tggggagacg ggaaaaaaaa gaggccgtcc tttttccggt gcaaatccca 2686621 ttccttaccc gccccaaggt gatccatgag cgaacggtaa cgatacttcg gaaaaattgc 2686681 aacactccta atatccgcat tcaccatgtt ggaaagcata aaatcaatca gtcggtacct 2686741 gccggcaaaa gggatcgccc cgagcgaccg ctgtgctgtt aaatcctgaa gagaatgctt 2686801 atatgtggtt tcatctataa cacctaacat ttgattattg aacactgact ctgccccctc 2686861 ttcagtaatt aaatcaattc tttttctaca aattcctctg aaacgagcag cacctcttca 2686921 atgtcttttt cggagcgaat cactgcgcca tccggcagca ccatcccatt aggaacgatg 2686981 gcattttcaa tgactacatg ctccccaatc gtcacatccg gcattatgac ggatgatgta 2687041 acagtcgtat gcttaccaac agtcacacct tgaaaaagaa cggagtgaga cacatttcca 2687101 tatacaacac aaccttcgtt cacaagcgaa tcttgaacct gcgcatcaga tgaaataaat 2687161 tgcggaggct gatttggatt gacggagtaa attttccatt tgcgttcaaa cagcttcagc 2687221 tccgagtcct cttttaacaa atccatattg gcttcccaca agctctgcac cgttccgaca 2687281 tccttccaat atcccttgaa cggataagca gaaagcttct ttttctcttc caaaagcagt 2687341 ggaataatgt ctttgccgaa gtcgtggcta gaataagggt tttgatcgtc catctcaaga 2687401 tactgtttca aaagcggcca attgaatata taaattccca ttgaggcaag attgctctta 2687461 gggaatttgg gcttttcatc aaaatgtgtg atcgtcccat ctggattggc cttcatgatg 2687521 ccgaaccggc ttgcttcctc ccagcccact tcgatgacag agatggtcac atctgctttc 2687581 ttttcaatgt gataatcaag cattttgccg tagtccattt tgtatatgtg atctcctgat 2687641 aaaatcagta catactcagg atcatactga ttcaaataat tgagattttc ataaatggag 2687701 cttgccgtcc ctttatacca tttgacttct gatgactcgg cataaggggg taaaaccgtc 2687761 acgccgccat tatatctatc caggtcccat gcactgccga tcccaatata ggaattcagc 2687821 tcgagcggct gatattgcgt taaaatcccg actgtgtcta tgcctgaatt agaacagttg 2687881 cttagggtaa aatcaataat cctgtatttt cccccgaaag atacagccgg tttggccata 2687941 ttttttgtta atccgctgag acggctgccc ttcccgccgg caaggagcat ggctacacat 2688001 tgttttttca tctttttatc tctcctcttt ttttaaccgc ccgtaaaatc gagatgccgt 2688061 aaggggggat ggtcatcgtg atataacacg gtttatgatg aagtgctccc tttttagccg 2688121 ataacggctt tttgttgatt tgccctgagc ctccatatgt ttcactgtca ctgttaagca 2688181 cttcaatgta ttgagtaaaa aaaggaactc caacatcata ttgatgatag accacgggtg 2688241 taaaattaca aatgatgaca agcgcctcac cgtgcttttg gccataacga ataaaagaaa 2688301 agattgattg ttcgtcatta tggacatcaa tccattcaaa cgattgtgca cgatggtcat 2688361 gctcataaag gattttgctt ttttggtaaa agcggagaag atcttgcgta aaaacgctgg 2688421 ctttctgatg catggggaag gagtccaaaa accaatcaag ctgttctgta tctttccatt 2688481 catcaaattg agcaaactct gatcccataa agatcaattt ctttccggga tgcactgtca 2688541 tatagcccag caaaagccga tactgggcaa atttctgcca gtagtcgcca ggcattttat 2688601 tgagaagtga tttttttccg tatacgactt catcatgaga aaacggcaat acaaaatgtt 2688661 cactaaacgc atatagtaat gaaaaagaga taagctgatg acaatgccgc ctttcttcgg 2688721 gcggcgtctc catgtatttc agtacgtcat tcatccatcc catattccat ttataatgaa 2688781 aaccaagccc cccttcctca acggcacctg tcacttgagg ccattctgta gaatcttctg 2688841 caatcatcat cacatgggga tatgcctctc tcatggtttg attgagtttt tttaaaaaat 2688901 caacagcata tggattcgtg tggcgttcat cctgatttgg ccaatacaag atattagcca 2688961 ctgcatcaac cctaaatcca tctatatgat agaattccgc ccagtacaac gcattcgaaa 2689021 ttaaaaaact atgaacttcc ggtttcccca ggtcaaagtt tgccgtgccc cataaccagt 2689081 tctcccgatc acgttcttct ttgtattcat aaagcggttc tccatcaaac atataaaggc 2689141 catgtgcatc tttacaaaaa tgtccgggga cccaatccaa aatgactccg atattttgtt 2689201 gatgacattc atccacaaac ttcatcagat catgcggcgg gccaaacctg cttgtcgggc 2689261 tgtaataccc cgttccttgg tacccccatg aacgatcata tggatgctca tacacgggaa 2689321 gcagttcaat atgggtaaac ccatgcttct tgatataagg gataagcgtc tgacttaatt 2689381 ctttatagga ataatgcctg ccatcagaat gcttcttcca agacccaaga tgcagttcat 2689441 aaatgaaaac aggtttttca tacagcgtct tagccttctg tttcttttgc catttttgat 2689501 cttgccagct gtatccttcc aaatcgtaag taagtgacgc tgtgtttggt ctgacttctg 2689561 aataaatagc gtatggatct gccttcagcc tgatctcacc gttattcgtc acaatttcgt 2689621 atttatatcg ttccttttct cctatacctg gaataaataa cgtccaaatg ccattatcat 2689681 tcactctgtg catcacatgc tcttctccag accagctgtt aaaatctcca gccactcgta 2689741 cttccgacgc atgaggcgcc cacacacaga attcatatcc gcttttgcca ttcagctcgc 2689801 ggtaatgcga gccaaacagc tgatagcttt taaacagact gccttcgtga aaaagataaa 2689861 catcatgtgc tgtcgggctg gcagcggcca tgtaatcatc ctttctgaca tcatagtttt 2689921 catttatagt atttattcga agaaataaaa aaaagccctt tcctgaaagc gcttatactt 2689981 atagacaatt aacttcattt tctgaagaaa aacgaaatat atggagattt ttgtagtctg 2690041 tttttaaaat aaagaacaaa atctaagaca tatcatgatt tataaaaaca aaaaaacctt 2690101 gcaggatatg caaggcttct ggatgacccg tacgggattc gaacccgtgt taccgccgtg 2690161 aaagggcggt gtcttaaccg cttgaccaac gggccgataa ttatgatatc tgtaatcata 2690221 tggcggagaa ggagggattt gaaccctcgc gccgcttaca cgacctacac ccttagcagg 2690281 ggcgcctctt cagccacttg agtacttctc catttggctc cacaggcagg attcgaacct 2690341 gcgaccgatc ggttaacagc cgatagctct accactgagc tactgtggaa caaaagtcat 2690401 ggtgggcctg aatggactcg aaccatcgac ctcacgctta tcaggcgtgc gctctaacca 2690461 gctgagctac aggcccatga cgatatagaa atggagcggg tgatgggaat cgaacccacg 2690521 acatcagctt ggaaggctga ggttttacca ctaaactaca cccgcaattt ttatttgggg 2690581 cgattgatgg gaatcgaacc cacgaatgcc agagccacaa tctggtgcgt taaccacttc 2690641 gccacaaccg ccaaagcata ttgataaatg gtggctcggg acggaatcga accgccgaca 2690701 cacggatttt cagtccgttg ctctaccaac tgagctaccg agcctaagta tttaaatggc 2690761 ggtccggacg ggactcgaac ccgcgacctc ctgcgtgaca ggcaggcatt ctaaccaact 2690821 gaactaccgg accattttaa aatttggttg cgggggcagg atttgaacct gcgaccttcg 2690881 ggttatgagc ccgacgagct accgaactgc tccaccccgc gatgattagg aatatgtatg 2690941 gcggaggaag agggattcga acccccgcgg gctttgacac ccctgtcggt tttcaagacc 2691001 gatcccttca gccagacttg ggtattcctc cgtatagtgg tggaccttgt aggactcgaa 2691061 cctacgaccg gacggttatg agccgtctgc tctaaccaac tgagctaaag gtccattggt 2691121 agcggcggag gggatcgaac ccccgacctc acgggtatga accgtacgct ctagccagct 2691181 gagctacacc gccaaatatt tttgaaatca agtggagcct agcgggatcg aaccgctgac 2691241 ctcctgcgtg caaagcaggc gctctcccag ctgagctaag gccccaagaa tggtcgggaa 2691301 gacaggattc gaacctgcga ccccatggtc ccaaaccatg tgctctacca agctgagcta 2691361 cttcccgatt tcatatagat catggcgcgc ccgagaggag tcgaacccct aaccttttga 2691421 tccgtagtca aacgctctat ccaattgagc tacgggcgca aaacttaatg ccgagggccg 2691481 gacttgaacc ggcacggtag tcacctaccg caggatttta agtcctgtgt gtctgccaat 2691541 tccaccaccc cggcgtggat ggtatagttg gagcggaaga cgggattcga acccgcgacc 2691601 cccaccttgg caaggtggtg ttctaccact gaactacttc cgcagaaatg gtgcggatga 2691661 agggacttga acccccacgt ctgtaaagac actagagcct gattctagcg cgtctgccaa 2691721 ttccgccaca tccgcaacat gtaaatggtg agccatgaag gactcgaacc ttcgaccctc 2691781 tgattaaaag tcagatgctc taccaactga gctaatggct cttcttacaa tagacttgaa 2691841 tattatatca tataaaagtg gtgccggcaa gaggacttga acccccaacc tactgattac 2691901 aagtcagttg ctctaccaat tgagctacac cggcatatat gtaaaaccga tatgtataat 2691961 gaaaaatggt ggaggatgac gggctcgaac cgccgaccct ctgcttgtaa ggcagatgct 2692021 ctcccagctg agctaatcct ccatacttgc actaacgtgc aattgcttgg cggcgtccta 2692081 ctctcacagg gggaaacccc cgactaccat cggcgctgaa gagcttaact tccgtgttcg 2692141 gtatgggaac gggtgtgacc tcttcgctat cgccaccaaa caaattgaga gtgttctctc 2692201 aaaactagat aacaggtgtg acatcattca aaaatatggt taagtcctcg atcgattagt 2692261 atctgtcagc tccatgtgtt gccacacttc cacctcagac ctatcaacct gatcatcttt 2692321 cagggatctt acttccttgc ggaatgggaa atctcatctt gaggggggct tcatgcttag 2692381 atgctttcag cacttatccc gtccgcacat agctacccag cgatgccctt ggcagaacaa 2692441 ctggtacacc agcggtgcgt ccatcccggt cctctcgtac taaggacagc tcctctcaaa 2692501 tttcctgcgc ccgcgacgga tagggaccga actgtctcac gacgttctga acccagctcg 2692561 cgtaccgctt taatgggcga acagcccaac ccttgggacc gactacagcc ccaggatgcg 2692621 atgagccgac atcgaggtgc caaacctccc cgtcgatgtg gactcttggg ggagataagc 2692681 ctgttatccc cggggtagct tttatccgtt gagcgatggc ccttccatgc ggaaccaccg 2692741 gatcactaag cccgactttc gtccctgctc gacttgtagg tctcgcagtc aagctccctt 2692801 gtgcctttac actctgcgaa tgatttccaa ccattctgag ggaacctttg ggcgcctccg 2692861 ttacctttta ggaggcgacc gccccagtca aactgcccac ctgacactgt ctccccgccc 2692921 gataagggcg gcgggttaga aggtcaatac agccagggta gtatcccacc gatgcctcca 2692981 ccgaagctgg cgctccggtt tccaaggctc ctacctatcc tgtacaagct gtaccaacat 2693041 tcaatatcag gctgcagtaa agctccacgg ggtctttccg tcctgtcgcg ggtaacctgc 2693101 atcttcacag gtactataat ttcaccgagt ctctcgttga gacagtgccc agatcgttgc 2693161 gcctttcgtg cgggtcggaa cttacccgac aaggaatttc gctaccttag gaccgttata 2693221 gttacggccg ccgtttactg gggcttcaat tcgcaccttc gcttacgcta agcgctcctc 2693281 ttaaccttcc agcaccgggc aggcgtcagc ccctatactt cgccttacgg cttcgcagag 2693341 acctgtgttt ttgctaaaca gtcgcctggg cctattcact gcggctctct cgggcttgca 2693401 ccctaacaga gcaccccttc tcccgaagtt acggggtcat tttgccgagt tccttaacga 2693461 gagttctctc gatcacctta ggattctctc ctcgcctacc tgtgtcggtt tgcggtacgg 2693521 gcacctctca cctcgctaga ggcttttctt ggcagtgtgg aatcaggaac ttcgctacta 2693581 tatttcgctc gccatcacag ctcagcctta tgggaaacgg atttgcctat ttcccagcct 2693641 aactgcttgg acgcggatat ccaataccgc gcttacccta tcctcctgcg tccccccatt 2693701 gctcaaatgg tgaggaggtg gtacaggaat atcaacctgt tgtccatcgc ctacgccttt 2693761 cggcctcggc ttaggtcccg actaaccctg agcggacgag ccttcctcag gaaaccttag 2693821 gcattcggtg gaggggattc tcacccctct ttcgctactc ataccggcat tctcacttct 2693881 aagcgctcca ccagtccttc cggtctggct tcacagccct tagaacgctc tcctaccact 2693941 gttcgaagaa cagtccgcag cttcggtgat acgtttagcc ccggtacatt ttcggcgcag 2694001 agtcactcga ccagtgagct attacgcact ctttaaatgg tggctgcttc taagccaaca 2694061 tcctggttgt ctaagcaact ccacatcctt ttccacttaa cgtatacttt gggaccttag 2694121 ctggcggtct gggctgtttc cctttcgact acggatctta tcactcgcag tctgactccc 2694181 aaggataagt cattggcatt cggagtttga ctgaattcgg taacccggta ggggccccta 2694241 gtccaatcag tgctctacct ccaagactct taccttgagg ctagccctaa agctatttcg 2694301 gagagaacca gctatctcca ggttcgattg gcatttcacc cctacccaca cctcatcccc 2694361 gcacttttca acgtgcgtgg gttcgggcct ccattcagtg ttacctgaac ttcaccctgg 2694421 acatgggtag atcacctggt ttcgggtcta cgaccacgta ctcatgcgcc ctattcagac 2694481 tcgctttcgc tgcggctccg catcttctgc ttaaccttgc acgggatcgt aactcgccgg 2694541 ttcattctac aaaaggcacg ccatcacccg ttaacgggct ctgactactt gtaggcacac 2694601 ggtttcagga tctctttcac tccccttccg gggtgctttt cacctttccc tcacggtact 2694661 ggttcactat cggtcactag ggagtattta gccttgggag atggtcctcc cggattccga 2694721 cggaatttca cgtgttccgc cgtactcagg atccactcag gagagaacga agttttgact 2694781 acagggctgt tacctcctat ggcgggcctt tccagacctc ttcatctacc tcgttctttt 2694841 gtaactccgt acagagtgtc ctacaacccc aagaggcaag cctcttggtt tgggctgatc 2694901 ccgtttcgct cgccgctact cagggaatcg catttgcttt ctcttcctcc gggtacttag 2694961 atgtttcagt tccccgggtc tgccttctca tatcctatga attcagatat ggataccact 2695021 ccattacgag tggtgggttt ccccattcgg aaatctccgg atcaaagctt gcttacagct 2695081 ccccgaagca tatcggtgtt cgtcccgtcc ttcatcggct cctagtgcca aggcatccac 2695141 cgtgcgccct ttctaactta accgttaaaa agaatcacta tgtgatatct tgtgttacta 2695201 attgaatgtg atgtctactg ttatctagtt ttcaaagaac acgtttcgaa ggaatgatcc 2695261 ttcaaaacta aacaagacag ggaacgttct gtttataaga ccttgggtct tatattccgt 2695321 ataatatcct tagaaaggag gtgatccagc cgcaccttcc gatacggcta ccttgttacg 2695381 acttcacccc aatcatctgt cccaccttcg gcggctggct cctaaaaggt tacctcaccg 2695441 acttcgggtg ttacaaactc tcgtggtgtg acgggcggtg tgtacaaggc ccgggaacgt 2695501 attcaccgcg gcatgctgat ccgcgattac tagcgattcc agcttcacgc agtcgagttg 2695561 cagactgcga tccgaactga gaacagattt gtgggattgg cttaacctcg cggtttcgct 2695621 gccctttgtt ctgtccattg tagcacgtgt gtagcccagg tcataagggg catgatgatt 2695681 tgacgtcatc cccaccttcc tccggtttgt caccggcagt caccttagag tgcccaactg 2695741 aatgctggca actaagatca agggttgcgc tcgttgcggg acttaaccca acatctcacg 2695801 acacgagctg acgacaacca tgcaccacct gtcactctgc ccccgaaggg gacgtcctat 2695861 ctctaggatt gtcagaggat gtcaagacct ggtaaggttc ttcgcgttgc ttcgaattaa 2695921 accacatgct ccaccgcttg tgcgggcccc cgtcaattcc tttgagtttc agtcttgcga 2695981 ccgtactccc caggcggagt gcttaatgcg ttagctgcag cactaagggg cggaaacccc 2696041 ctaacactta gcactcatcg tttacggcgt ggactaccag ggtatctaat cctgttcgct 2696101 ccccacgctt tcgctcctca gcgtcagtta cagaccagag agtcgccttc gccactggtg 2696161 ttcctccaca tctctacgca tttcaccgct acacgtggaa ttccactctc ctcttctgca 2696221 ctcaagttcc ccagtttcca atgaccctcc ccggttgagc cgggggcttt cacatcagac 2696281 ttaagaaacc gcctgcgagc cctttacgcc caataattcc ggaaaacgct tgccacctac 2696341 gtattaccgc ggctgctggc acgtagttag ccgtggcttt ctggttaggt accgtcaagg 2696401 taccgccctg ttcgaacggt acttgttctt ccctaacaac agagctttac gatccgaaaa 2696461 ccttcatcac tcacgcggcg ttgctccgtc agactttcgt ccattgcgga agattcccta 2696521 ctgctgcctc ccgtaggagt ctgggccgtg tctcagtccc agtgtggccg atcaccctct 2696581 caggtcggct acgcatcgtt gccttggtga gccgttacct caccaactag ctaatgcgcc 2696641 gcgggtccat ctgtaagtgg tagccgaagc caccttttat gtttgaacca tgcggttcaa 2696701 acaaccatcc ggtattagcc ccggtttccc ggagttatcc cagtcttaca ggcaggttac 2696761 ccacgtgtta ctcacccgtc cgccgctaac atcagggagc aagctcccac ctgtccgctc 2696821 gacttgcatg tattaggcac gccgccagcg ttcgtcctga gccaggatca aactctccga 2696881 taaatggatc acaggttaag ttcaccgcat cctgcggcga cacctgtgtg acctgcgtcg 2696941 tgcaggccct agtttgactg actacgcaca tcgcagtgcg atttttaaaa actgaattaa 2697001 caggtacgtt ttgtcttgtt tagttttcaa agatcatttc gttacttctc aatgaagcag 2697061 ctttactaat ataacattca gcttcttttt tgtcaacaac ttttttcaag ttgttttgaa 2697121 gcatctagtt tgtgtccgct gtgcatcagc gacgtttaat aatataacac ctgtatttat 2697181 ttattgcaat agttttttaa aaaaaatcta taaaacaaat aaactataat cctcgccatg 2697241 atttctaaag cgtgtgtatc atataagttt cttaaaagaa catatacatc agtcatgtga 2697301 tcttgttgtt tttttcgttt tcttgtatag tagaaacgaa ctaaatactg atgaccacaa 2697361 ggggagcatt aaagctgaga gtgagcggtt tcgttctgac cctttgaacc tgttagttaa 2697421 cgctggcgta gggatgtggc aaagtcaaat gaattgcaga tcgtaaagca gtgcgtggaa 2697481 cttttctcat ccttccgcgt gctgcttttt tgttgtcctt ttggttgtct gtcaatggaa 2697541 ggagatagat atgaatcaat ctaagcaact ggttcgcctt attgaaattg ccattatgac 2697601 agcggcagcc gttattttag acattgtctc aggaatgttt cttagcatgc ctcaaggagg 2697661 ctcggtctcc atcatgatga ttccgatctt tttaatttcg tttcgctggg gtgtcaaagc 2697721 aggtcttact acaggtttgt tgacaggtct agtacaaata gcaatcggaa acttgtttgc 2697781 tcaacatcct gtacagctat tgttagatta cattgtcgct ttcgcagcaa tcggcataag 2697841 cggctgtttc gcttcttctg tccgtaaagc cgctgtatca aaaacaaaag ggaaattgat 2697901 tgtttcagtg gtcagcgcag tttttatcgg cagtttgctg cgctatgccg cgcatgtcat 2697961 ttcaggagct gtgtttttcg gcagctttgc tccaaaagga acaccggtat ggatttattc 2698021 tttaacttat aatgcgactt acatggttcc ttcattcatt atttgtgcaa ttgtcctatg 2698081 tttattattt atgacagcac cccgtctgct taaaagtgac aaagcgtaaa agtaacaatc 2698141 ccccagcgaa ttccgctggg ggatttttcg ttatctgtta agaagtgttt ttaaagctga 2698201 aagatccggc cagccaagac ctacttcttt cagccttact ccggcaattt caaagttgtc 2698261 ctccgctact ctttcaggtg aataggcctg ataaaatata atcgagggat tctgctcaat 2698321 aacccaaaca aacatacttg aaaaaccatg ttgaagcaaa aactccgctc cttttgctaa 2698381 gagcgccctg cctgcacctt gccgctggcg ctcttccaga agataaatag cgtataactc 2698441 gccgtcatag ccttcttgtt cagagcgaat aggtccaaat gaagcaaagc cgaatactga 2698501 acccttttcg tcctgagcaa caaatactcc ctttaacgag cgacttttcc atttgtcttc 2698561 aaattcctta tagttcaggc tgtttaaata atcaatcggg ataatttcgt ggtatgttgt 2698621 cctccagctg tctacatgca cttttgcaat gtcctttata tcctctaact tcgcttcacg 2698681 tacagttacc atacggttct gccctttcct tactctgatt tttggatcgt tttggcttct 2698741 ttgatttcat ttgttaattc attaatgctt tgttttacgt ttccttttcc tgaaaagttc 2698801 tcaagcattt cttttacatc aattcctgag gatgctttta aactttcttg cagacttgac 2698861 attaagttcg tcgcatagct ggttactttg tttgctccgc ttgattcacc gcttcctcct 2698921 gtatcgacaa cggtgatttt atcaatattt gaaagaggtg ccgctgcttg tttcgcgtat 2698981 tccggaagca ttttgacaat catatcgaaa atcgccgcct gcccgtactg ttcaaaggcg 2699041 gccgcaattt tctcttttgc ttccgcttct gcaagacctt tcaggcggat aacctctgct 2699101 tctgtctctc ctttcgcttt ttccgcttct gcttttgcta gcccgtcaat tcttactttt 2699161 tccgcctcag cctttgccat tgcttcaata ctgtacttct tggcatcggc ttccgcgagc 2699221 tgtttggctt tctcagctgc tgcggactgc tcaacagaat aacggtctgc atcggctttt 2699281 ttctttacct ctgagtcgta ttgacgttca cggcgaagaa tttctttttc ttctagttct 2699341 atttgttttt ggcgttcgat aattttaacc tgcatttcct gctctgtgac ttgctggcgc 2699401 gctcgggcag tctctaaatc atatgcttgg tcggcattcg cttttgccgt atcttgttct 2699461 ctgcggaatt cagccatttt gagctgattg attttttcag cttcagcgat ttccgtcgcc 2699521 cgttcaagtt ctgatttttt tgcgtcttta tcggcttctg cccgcttaat tcgggtttct 2699581 ttatcagcct ctgctgttgc gatatcagca tcgcgtttta cttgggcaat tctcggtttc 2699641 cctaatgatt caagataacc gtttttatca cgaacatctt taatggtaaa cgagacgatt 2699701 acaagtccca ttttcgcgag atcctgtgaa gcgacacgct gcacctcttg agagaatttt 2699761 tctctgtttt tatagatttc ttctactgtc attgagccga gaatggaacg aaggtggcct 2699821 tctaaaacct cccgcgcttc ctgctcacgg tcgtcttttg atttccctaa aaattgttcg 2699881 gccgctgtag cgatttctcc tatagaaccg ccgattttaa taatcgcagt tccatcggcc 2699941 attactggca ctccttgttc tgtatagact tcaggtgtcg aaacatcgag tttgcttgat 2700001 aataggctta gcggctctgc ctgctggaag acgggaagga caaaggttcc tccgccgcgg 2700061 acgattttaa tacggttgcc gccttcatcg acatgaacat ttttattacc cagatagctc 2700121 cctgttacaa ttaacgcttc atcaggccct gctgtacgat acttcgtaat aaacacagct 2700181 attagtgcaa ttaataaaaa gaatacaact ccgatgatca ttataatcgg cattgtcata 2700241 tcaaattcct ccttttatgt taaatgggtt catgcggagt aaccgaaaga actccgttgt 2700301 taatatctac gactaacacc gttgtcccgt aactgatctg ctgattatca aaactgaccg 2700361 ctgactttga aatggtcccg cctatccctt ctatgaccac ttcaccaaac ccgtcaaccg 2700421 gcacagctgt aatcacttta ccgagtcttc ctctgagatc atcttctcta tatgccaatg 2700481 attcttctgc agatgataat ggcaccagta caaagatgtg aagcaatacc accagcatga 2700541 tcgaaaggat gcaagataaa agcgcaatca gcaagcttga cagaggcaat acaagttcac 2700601 ctatatatcc gcccgctgaa aaacatgtaa aaaatgagag cactaatgtc ggattaagaa 2700661 acggaatgcc ttctgacagc cctgaaaata catctccgaa aaacaggaat aacagcgtaa 2700721 ggctgcccgc aataataagc gtataaagat acattgtttg tataggtact ccaaataact 2700781 ccaacttcct catcctttct tcatcaatgc attgatgaac ggctgccgtt accatttata 2700841 cgagacacct cgggaaaagt ttcaaaattt taagacaaat aacccatttg aagtgcttta 2700901 taaatgataa ttgcttatat atatggtaat gtcattttag gaggagatat gatgagtatc 2700961 tttaatgaag ccagattaga aacgtggaac gaattgaaag gactttctga cgaaaagctg 2701021 aatcaaaagc cttctgctga agaatggagc atacgggaag ttcttgacca tttgaaaaaa 2701081 atcgatatga ccgcacaaaa aatgttgaag gaacgtgtaa aggacgctcc gattaaagaa 2701141 attgaagaaa aaccgcttga agtagcacag gacagaaata ataaacggaa agccccgagt 2701201 catcttgagc ctgcgcatga ttttatttca ggcagccaaa tgaaacgtga gcttgatgtg 2701261 gtaagagagc agctgactgc tgcgattgcc tctctgaaag aagaagattt tgaaagagtg 2701321 cttccgcatc ctgtgtttca agagctgact gtcagacagt ggatcgattt tatcggccat 2701381 catgaaaaac ggcacctcag ccaaatgaaa gaaattaaag aaaagataga aagggcctga 2701441 tttaatcaga ccctttctgc ttttcgtttg acttttcgct gataggaatg aacttctatt 2701501 tcatcacctg tgtaaacagc accaggtctc tccacaatac agacaatccc tctaatgccc 2701561 agtgcgtggc ggacgaaagc cgacgccagc ttcggttggt ccggataata agactgaatg 2701621 acttctcccg gctggataca cggatcattt tcgccctcac acagcagagc cgctccgctc 2701681 ggaaaaataa tccggcttcc ttcttttaat gaagtaagat ctggcatacc gctgactgcc 2701741 acattcgccc cgagccattc cggcaaaatt ctcggcactc ccatttttaa agcgatttcg 2701801 ttgcattcct ctattgaaac aattgaaatt tgtctgcggt tgaaaatttc agtccctctt 2701861 gaaaacattg gttctctggc tcccgctttt ttggtcaggc caaaatgcaa gtcgccgggg 2701921 atgccgccat aatcaaaatc aagcttgtcc atttgctttg ttacgaagct ttttgtatct 2701981 gcgatatata agccttccgc ttttgcagtc atacgcttcc acatcagctg gcaccttcct 2702041 tcttatctaa aatttccacc tatgcttcat tatcccaaaa aatcccgctc tgtaaaggag 2702101 cgggattttg attataccgt tttaggcgta aggttaaagc agcgtttgta gatccagttg 2702161 tatgcttttt catttaaatc tctagggttt ccgaaggttt gcggatcttt cattgcttct 2702221 ttagacaagc gttcgatcat atcaggtgat actccctgct cttctaaagt cggcacttct 2702281 aaatcttcga ccagatcata catccaattg acagatgctt tcgcagcttc ttctgttgtc 2702341 atcttgcttg tatcaatacc gaacgctttc gcaatacgcg caaacttctc aggatagccc 2702401 ttccagttgt attccatgac agggcccatc atcgccgcta cacattggcc gtgagcgact 2702461 gggataatac cgccaagcgt ttggctcatc gcatgagcag cgcccgctga ttcacttccg 2702521 taagaaagac cggcaagcat cgcagcctgc gccattccgt accttgcttc cagatcctct 2702581 ccatcagcaa atgccctctt gatgtaatga gcggcatact caatcgccat taaggcaacc 2702641 gcatccgtga ttggctgtgc aaatttcatt gtatagcact caatggcatg ggcgagcgca 2702701 tcaattcccg tcatagctgt tacatgcgga ggcattgaaa catgaagctc aggatcaatg 2702761 attgtcaagt gcgctgcaat cagcggaccg cccgtgttga atttgaattc tctttcttca 2702821 tctgtgataa ccgcccattg ggttacttct gatccggttc cagctgtagt gggaattgtc 2702881 gtcagcggag gaatgcggtt ttccagcggt tttttcccat ctgccgcttc ataatcaagc 2702941 acgcttcctt cgtgagtcgc ttctactccg attgcttttg ctgtatccat ggagcttccg 2703001 cctccgactg ccaccaaacc attacagttc tcttttttgt aaagctcaga tccttcattc 2703061 accagacgga caggcgggtt tggctcaact ttattaaaga gtaccacttc aatgcctgct 2703121 tctttaagtg attcgattac gggatcagca acaccggctt tataaatccc agggtctgtg 2703181 acaaggagcg cttttgaaac gcccagtgca gctacttcct cacccgtatg cttgatggct 2703241 ccgattccat gcttaatcac agtcggaatt tcaaatgtgt ggaatttctg catgctttct 2703301 accttcatat ttaatgtcat catcaatctc cccctcttat gaattaaacc agttaaccgc 2703361 tgccggtttt gtattgcggt atacatgttt gacttctgtg tattcttcaa ggcctatttt 2703421 tccaagctcg cgtccgaacc cggattgctt atatccgccc catggcgctt gtgcaaagta 2703481 cggatgaaaa tcgttgatcc aaacggttcc cattctcaag cgggctgcta cccgttcgca 2703541 cttttcaatg tcttttgacc ataccgctcc agccaagcca tagatggtat cattcgcaag 2703601 ctcgattacc tcttcttcag agctgaaggt ttcgactgtc aatacaggac cgaaaacctc 2703661 ttcctgaacg attctcatgt cagaattaca gtttgagaaa atagtaggtt catagaaaaa 2703721 gccgttttga agctcaggat cttccgggcg tttgcctcct gtctccagct tcgcgccttc 2703781 ctctattccg atctctacat atttttctac ctttgccctg tgctccgccg aaataagcgg 2703841 accgctttct gtctcagcat gaaaaccgtt tccgagtttt atgcgttttg cccgtttgac 2703901 cagctccgcc aaaaattgat catgaatggc atcctcaaca agcaagcggg aacctgcaga 2703961 gcatacttgg ccggcgtgga aaaatacagc gtttaaggcc tgatcaaccg caacttctaa 2704021 atccgcgtcc ttgaaaacaa tatttgggtt tttcccgcca agttcaaggg cgattttttt 2704081 gacgtttccg cttgccgccc gcatgatttt tttgcctgtt tcaattccgc ccgtaaatga 2704141 aatcaaatcg acgtctttgt ttacggcaag ctcgtcgccc actgtggctc ccggtccaag 2704201 aacaagattt gcgacacctt ttggaacacc ggcttcttcc atcagcttaa agactttgat 2704261 tgtcgtcagc ggcgtaatct cactcggctt catgacgatt gtgtttcctg cggccagtgc 2704321 aggggcgatt ttccagctcg cttgaaggag cggataattc catggagtga tctggccgca 2704381 aaccccgatt ggctccctaa taattttgct ttctgaatca ggaatcggag atgaaatgat 2704441 ctctccgcca tctttgtctg ccaagccggc gtaatattga aaaacattgg cgatatcgtc 2704501 catatcggcc ttgctttctt cgagtgtttt tcctgtatca agagattcaa gctcagccag 2704561 ctcctcaaga tcgcgtctga ttaattccgc aattttcaga acaatttttc cgcgttcaag 2704621 cccggatagc gatgaccatt ctcctttgtc aaatgctcta cgtgcggctg cgattgcttt 2704681 gatggcgtcc tctcgccctc cctcgcttac agttgcaatt tcttcttgat taaatgggtt 2704741 gataatactg cggatctgtt ctttttcggc actgatccat tctccgtcaa tgaataatgt 2704801 ttgactcata taagcctcct tgacgtaaat aaagtttgtt aaataaaaat ttaatgtttt 2704861 taacaacctt aatctaacat atggttttta aactgtcaaa gtcccatttt gatttttctt 2704921 tttgactttt cctcatgttt cgttaagata aagaacataa agaaataact taacgaattt 2704981 aattttctaa aggaaaagag ggtcagtatg gatgaaaatc cagaatttgc agctatagaa 2705041 caggctcggg atcttgttat tgactccatt gctgaaacga tggatcttta cggaattacc 2705101 cgcagtgtcg ggattttata tgggacgatg tatatgaggg atgagatgac gcttgacgaa 2705161 atgcgtgagg agttgcaaat gagcaaacca agcatgagca ctggcgtcaa aaagcttcaa 2705221 gacttaaatg tagtgaaaaa aacatttcac cggggcatcc gcaagcatac atttgtggct 2705281 gagaaggatt tctttaaatt tttcacaaat ttctttccac ctaaatggga gcgggaggtt 2705341 caagtgaatg taacagcgat cgaggaagct caagctgatt tacaaaaggt tttatgcaag 2705401 gaagatctcg atgaggatat caaaaatgaa gcactgcagt tatatgatca gctggaaagc 2705461 tctaaagctt actatgactg gctgaaacgg cttgctgaat cggtgcagac cggagaaatt 2705521 tttaaattta taccggtcga aacaaagtaa agcagaaaac gcctgggaaa ctaggcgttt 2705581 ttttgatgta actactacaa atttgaaaaa tacgggaaaa acaccccatt tacttccaaa 2705641 atatttgatg gtaattttat gtaggtaaaa tttgtatttg gcctttcaga ggaggtgaaa 2705701 agcgggcagg cctgtttaat ttatcatttt ttagggggaa ttttgttatg aaacgcaaat 2705761 tattatcttc tttggcaatt agtgcattaa gtctcgggtt actcgtttct gcacctacag 2705821 cttctttcgc ggctgaatct acatcaacta aagctcatac tgaatccact atgagaacac 2705881 agtctacagc ttcattgttc gcaacaatca ctggcgccag caaaacggaa tggtctttct 2705941 cagatatcga attgacttac cgtccaaaca cgcttctcag ccttggcgtt atggagttta 2706001 cattgccaag cggatttact gcaaacacga aagacacatt gaacggaaat gccttgcgta 2706061 caacacagat cctcaataac gggaaaacag taagagttcc tttggcactt gatttgttag 2706121 gagctggcga attcaaatta aaactgaata acaaaacact tcctgccgct ggtacatata 2706181 ctttccgtgc ggagaataaa tcattaagca tcggaaataa attttacgca gaagccagca 2706241 ttgacgtggc taagcgcagc actcctccga ctcagccttg cggttgcaac taatgtaaaa 2706301 gaccggttaa cgccggtctt ttttgcgttt taccctcccc tttttctcta atccccgtta 2706361 tcttttttct ggtttaaaat ttaaattgac aaacactaga aacaggagta aattcttgag 2706421 tgttcaattt catacagtct cttttaccgc ttaatcaaac acgaacgggg gaaccaacga 2706481 ttggctgttt tattaacagc cttggggtga atcttactaa gtaagagggg gtactctgaa 2706541 tccctaatcc gacagctaac ctcgtaggcg tatacagaga ggaggtctat tatcggccat 2706601 tctttgcaat ggtctttttt gtttcaaaaa cgttaattca ctaagggaga tatgaacatt 2706661 gggaagaatt aaaaataagc aatttgccgt gatcgggctg ggccggtttg gcggcagcat 2706721 ttgtaaagaa cttcatagaa tggggcatga ggtccttgcg gttgatatca acgaagaaaa 2706781 ggtcaatgca tatgcttctt acgccactca tgcggtaatt gccaacgcca ccgaagaaaa 2706841 cgaattgctt tcattaggaa tacgcaattt tgaatatgtg attgttgcca tcggagcaaa 2706901 tattcaagcg agtacgctga ccaccctatt attaaaggag cttgatattc caaatatttg 2706961 ggtgaaggct caaaactatt atcatcacaa ggtgcttgaa aaaataggcg ctgaccgcat 2707021 tattcatcct gaaaaagata tgggggttaa aatcgcacaa agcctttcag acgaaaatgt 2707081 tttgaattac attgatctat ctgatgaata cagtattgtc gagctgctgg ctacgcgcaa 2707141 gcttgattca aaatcgatta ttgacctgaa tgtaagagca aagtacggct gcacgatcct 2707201 ggccattaaa catcatggag atatctgtct ttcccccgcg cctgaagaca tcattcgcga 2707261 gcaagattgc ctggtgatca tgggccacaa aaaggatatt aaacgttttg aaaacgaagg 2707321 gatgtagaca aaggtgacac ttcaaaagga taaagtgatc aaatgggttc ggtttacacc 2707381 gcctcaagtg cttgccattg gttttttcct taccattatc atcggggctg tcctattaat 2707441 gcttccgatt tccactacga agccattgtc atggatagat gcccttttta ctgcggcttc 2707501 cgctacaact gttacagggc ttgctgttgt cgataccggc actcaattta cggtattcgg 2707561 gcaaacagta attatggggc tgattcagat tggcgggctt ggatttatga catttgcggt 2707621 cttgatcgtc atgatattag gaaaaaaaat cggcttaaaa gaacgaatgc tcgtccagga 2707681 agccttaaac cagccgacaa tcggcggtgt cattggcctt gtcaaagtcc tgtttctgtt 2707741 ttcgatcagt attgaattga tagcagcact cattttatcc atccggcttg tacctcaata 2707801 cggctggtca tccggcttgt ttgcaagttt gtttcacgca atatctgctt ttaacaatgc 2707861 cgggttttcg ttgtggcctg ataatttgat gagctacgtt ggcgatccta cagtgaacct 2707921 cgtgattact ttcttattta ttacaggagg gatcggattt acggttctgt ttgatgtgat 2707981 gaaaaatcgg cgttttaaaa ctttttcttt acatacaaag ctcatgctta caggaacgct 2708041 gatgttgaat gcgatcgcta tgcttacggt ctttatttta gaatacagca accccggcac 2708101 gctcggccac ctgcatatag tggataaact gtgggcctcc tattttcagg cagtgacgcc 2708161 gagaaccgca gggttcaatt ctctagattt tggaagcatg agagaaggaa caattgtatt 2708221 tactttatta ttgatgttta tcggagcagg aagcgcatca acggcgagcg gcattaagct 2708281 gactacgttc atcgtgattt taacatctgt tattgcttac ttgagaggta aaaaagaaac 2708341 ggttattttc cgccgttcca tcaaatatcc gattatcatt aaagctttag ctgtgagcgt 2708401 caccagtttg ttcatcgtgt ttttagggat tttcgccctg acgatcacag aacaagcgcc 2708461 atttcttcaa attgtgtttg aaaccttttc cgcattcgga actgtcggcc ttacgatggg 2708521 gcttactcct gaactgacaa cagctggcaa gtgtatcatc attgtcatca tgtttatcgg 2708581 aagaattggt cctttaacgt tcgtgttttc attcgcaaaa acagagcaat caaatatccg 2708641 ttatcctgat ggcgaagtgt ttacagggtg atatcaaaaa aatccggcgt gcagtcgccg 2708701 gattttttat gattcgatat gagattgatt ttgtcttttt tcctgttccg cgatgatttc 2708761 gttatcctcc gcgttatcac gggtcacttt ttgcgtaaga atcgcaccaa ctgctacaag 2708821 tatcataaca gcgatgtaat aacctttttc attgagttcc agattatcag cattatagag 2708881 tccgatacta aacaaaaata ctcccgcaaa aaaagtaaaa taagctagta ctgtaaaggc 2708941 aaccgtgttt ctgcgtctat atttctgcac ctttgttccc tcccgaaagc atagttaaaa 2709001 agtgataact tccgtggaat attatacctc aaattccccg gaatggaaca aagaattaaa 2709061 aataccagta aaaagggctt aggttgcctc ctttatttca acagctgaat catcaatcca 2709121 gccgataagt ttatcattga tttggaattg gtaccataca gactggcctt tctgtttttt 2709181 agacacaacc tttatgtctt tgccgacgta agattgggca gaggtaagcc ttatggaccg 2709241 atcatcagta gaaggcttgg accatacgtc ttgaacggca ctgtctttaa tagaggcgtt 2709301 taaatccaca gatttgaggg atggatttac ctcatcgtac tcatctaaat cgtatttttc 2709361 cacaatagcg ctgattttgt cagcgtagtc agggtctgta gcatatcctg atgtttgcag 2709421 ggcggttgcc gcttccttat aattccctgc ctcaagcacc ggtttatact tctttttatt 2709481 ccacgatgtg ccacggacga acaattgggc gtgatcatcc atagattcaa aaaacgtgct 2709541 gtattttcga aacttcgcgc gaatggtttt tcttttccct ttttcaactt cgtccgtttc 2709601 catcgtgaca tgatggcctt tataattccc ttttacgcca aaaaggttgt tggccttagc 2709661 agccagttca ctgttccccc agtccgattc gagaatggcc tgagcaattg tgatgctggg 2709721 gagaacatgg tatttttcat acaaaatttg ggcatgtccg gacagactgt ctataaatac 2709781 ttgctgttca tcgatttctt cagtttcttt ggatatttca atcggttttg ataaagttgt 2709841 cgctaaaaca aacagagcta gcggaatcga tacaaggaaa aatagtgaaa tcaagagttt 2709901 acgtttttta agttttttac gggccatgaa aaccttcctt cgaattaaaa gattacgaat 2709961 gtaaaagaat ctacctttta gaattttact tgcacttcta atatttttca attctttagg 2710021 gataaagttg ggaaaagatt gcaaaataaa aaccttttcg ctcaatgaaa aggtttttac 2710081 catgtttcta tttttgtaaa tttctgagtg cattccgata ttccgtatca tttattactt 2710141 tatatgattt gacagttgcc ttcgacaaac cttgtgctga gacggccggt ttttccggag 2710201 ctgttttcgc tttatcatgt ggtttatgtg ccagcttgtg ccccattcca gtggcattca 2710261 tacaaaatga caggcagacg agcagcacgc taaggataaa agaaatgaag aagagatcat 2710321 gataagcagt catcatagaa tcctgtaccg aaccgctttg tctggcagca tcttttttcg 2710381 tgaaaaagcc gatgagaatg ggaactccca tatagacaaa caatcttaaa aactgaacag 2710441 ctgtcattct cttgaccaaa tcaggcagcg ggcctcccat ggcagctccc atcagccctg 2710501 cggcgactgt caggcctgtt cccgctgcaa gcatgataaa cagtgccgcg aacatataaa 2710561 gagatgatcg atcctgtata tgcagccatt gaaaattcac aaaaacgaga atgagtccgc 2710621 cgataatacc gagcatccct ggtccgactt tatcgtataa cagagcgctc aaaatggccg 2710681 cgatcgccac tccgattaaa agagtcaagc ttaaaagaat gagatgctcc tgagaaatat 2710741 catacatttg acggagcaag ccttgaaaag cagaaaggct gacagctacc gttatcgtcc 2710801 ctgcagctat gatcaataag ccgagcaccg gttttggcag cagcatcagt ttaatagata 2710861 tgaaggggtt tttcacttta tattccacaa tcaatagacc aatgagcaaa cataacgtca 2710921 ccccgaaacc aatccataca taacccgatg acagccccca tttttgcaga aaaatgaatg 2710981 aaaccgctga ggctgcggca aggaagacag ataaaagaat tcccgcacga tcaagcggct 2711041 gttcttgatc cgccgctccg tgatgctcat catgaagaaa gaaatagctc accgcgacac 2711101 cgatcaggga caaggtgcca aagatgaaaa acagccatct ccaatgcccg cagcttgttg 2711161 caatggttcc caggattgta ccgatgataa cagaaccata gaatcccccg atcagcacaa 2711221 gcagtgcata gttcctgcgt tcaatcggga atgacagtac aagcattgga atcataatca 2711281 tcagcatgac gcctgttgcc gccccttgta aaaagcgccc tgccgccatc aatgcaatat 2711341 cgcctgaaca tgcgatgagc agtgagccta gtataaagac aggtaatgaa gccagataga 2711401 cgggacgagc accgaatttt ttcctcagca gcggtcctgc cggaactaac aaggcaaagg 2711461 ccatattgcc gatcaatatc ggatttactg atgtaaagac acttgttcca accgttttct 2711521 gaacaaggcc ttgaactgac gacaatgccg tgttagacat caatcccggc ccgaccgcta 2711581 agacggcgag caaagaaatc acccaatagt gttttgtctt catgttgtca tcccttccta 2711641 tatgaataca tgcgaaacac atcatttttt gaaaacaaaa gaagctaata gattttgcat 2711701 accattagct ttcattctaa tattctccct ttcaggggaa atgatattat tttattataa 2711761 ttatgtgaat gaatgagcat ataatcaaat attatttcaa atcgattgtg ttttgtcaat 2711821 ggagtaaatt tcaagcacaa catagaaagc ttgaaagctt ttccccgata ttgtgtctag 2711881 aactgcactt atgaatccct gctcgttccc tcaagcgaat taaagcaggc cgttttaatc 2711941 ctttcaatcc actattccaa ctaataaact caaataagtt ggtgataaga caacatttta 2712001 cccccacatt tttttgtgtt cactgggcgt ttgccgcctc taaattgtat atgggtaaat 2712061 accatgaatt aacctatgaa ataccaatgt aagggaggca aaaacgaatg gaactgtatg 2712121 agtgtatcca agacattttt ggcggcttga aaaatccatc ggttaaagat ttagcaacgt 2712181 ctttaaaaca aattccaaac gcagcaaaat tgagtcaacc gtatattaag gaaccagacc 2712241 agtacgctta cggccgaaat gccatctatc gaaataatga attggaaatt atcgtgatta 2712301 acattccgcc aaacaaggag acaacagtac acgatcatgg tcaatccatt ggttgtgcaa 2712361 tggtgttaga aggaaagctt cttaattcta tttatcgttc aaccggcgaa cacgcagaac 2712421 tctccaattc atactttgtc cacgaaggag aatgccttat ttcaaccaaa ggtttaattc 2712481 acaaaatgtc caatccaaca tctgaacgaa tggtgtctct tcatgtctac tcccctcctt 2712541 tggaagacat gacggtcttt gaggaacaaa aggaggtatt ggaaaattca tgattgacag 2712601 ataaactgct cactttgact tcactcaact ggaggattca gagaatgaaa ccttttcctc 2712661 aaaacaaaaa aacccttatc gaataagggt ttaaaggtat ggagccaagg gggctcgaac 2712721 ccctgacctc tacgctgcca gcgtagcgct ctcccagctg agctatggcc ccgtatgtaa 2712781 cgtcatgttt attatagatg attttatttt gaaaaacaag ctgtttcctc ttgaattgac 2712841 agaaaaaata aggctcggaa aagagcctta tttttcgact tacatcatga tcaaaagtaa 2712901 aatcacaccg agaataattc gatagattgc aaatgggaca agtttgattt tgttaatcag 2712961 ccttaagaag aaacggacga caaacagtgc gaccacaaag gcacagataa agccgacgat 2713021 gaaaaacggc atcagatccg aacttaagct gtcccaatgc ttcacgaggc ttagaaagct 2713081 ggctcccatc atgatcggca tcgccataat aaacgtaaag tcggctgcag ctcggtggtt 2713141 taatccgaga ataacaccgc cggaaatggt tgaacccgaa cgcgagaaac caggccaaag 2713201 ggaaagacat tggaataagc cgacggctat cgcctgttta taggaaatgc ggtcgagtgt 2713261 gtctgtcgct gttttccgtt tattgaccca gtcagcaaaa agcatgagga ttgccccggc 2713321 aattaaaccg atggccacag ttttaacgga aaataaatat tcatcaatgt aatcttcaaa 2713381 caaaaagccg agaacagctg caggcacgag tccgacggca atttgggcaa tgcttaattt 2713441 atgtccctgc tcctggtcgc ttgtaatatt ttttttcaag cccagtaaat ttaaaattcg 2713501 gtctttaaac acgatagcta ctgctaaaat ggagcctagc tgaataacca ccttgaatga 2713561 gttagcagct tcttctgaca tcagattact tgattttagc cagatgtcgt ctactatgat 2713621 catatgtcct gtcgaagaaa ccggcgcgta ctctgttaat ccttctacga ttcctaaaat 2713681 ggcggctaca aacaattccc atagagtcat gattttgatt ctccccatta gacatttatt 2713741 tttttacata acgggagctt cccataaatg gaaagcccgt cttatataac tataaacgaa 2713801 aatcacactt tatgccccgg cgtattttca tttttttctt catcgtataa atgtgactgc 2713861 attttaaacc agtcaaataa atgtgtcgta atgactttgg caaccgcata gccgggaatc 2713921 gcaagaatga ttccaacaac gccaaacagc ttgccggctg ttaacagcag aaaaataatc 2713981 gtaatcggat ggatgtgaag gttttttccc ataatttgcg gagagatcag cttcccttca 2714041 atcagctgaa caatcgtcca aacgatcacc agcttaagca gcatgagcgg cgatgtcact 2714101 atggcaatga taatcgcagg cgtaatggca atcgttggcc ctaaatatgg aacgatgctt 2714161 gtgcaagccg caatgactgc aagcaatgaa gcataatcca gcccgataat caaataaccg 2714221 ataaacagca aaaacccgat acagaagctg acaatgatct ggcctctgat ataagagctt 2714281 aaccgatgat tcatttcgct taagactgta tatgtctgtt ctttcaatcg agtcggcaca 2714341 aacttcagta tgtagaccgg taattttctt ccgtctttta gcaaataaaa tagaataaac 2714401 ggaaccgtga cgatcgaaat gataatctca gtcagtgcgc cgataaaatt cccaacaccg 2714461 gtaaaggtgc tgttcacgat cgtcgctgcc tgatccgaaa cctttgtagc aagatcagat 2714521 atattaatgt tcatcgtttg ctgggcctga ttgacgaagt tgctgccaat cagctgtttc 2714581 gtctgatttt ctacgacgtc cacatatctc gggatattgt caatcaaact cataatttgt 2714641 tcttttaaga agggaatgat cgacacgatc gtgatcgtga tcagcccgat aaccaatagg 2714701 tatagcagca atatagaata gattcttctt attcttcttc tctccagaaa atcgacgact 2714761 gggtttaaca gataaaaaac aatgcctgtc aaaataatcg gaagtgatat cgttttgagc 2714821 agaacaataa tcggggtgaa aataaatgat gtttttgtaa atactagaat atttaaacca 2714881 atcagcagca gcacaagcaa aaataaaaca aacttattat ccaagaagaa tcgcttgaat 2714941 ctgccgctcc atgtttgcaa cgtctccact atcgttcctc cgtcatacat agtttaatta 2715001 aattgtacac tatcgtccct ataatgaaaa ataaaaaccg ttaattgctg gaaaagcttt 2715061 ctcggtttta acattctatt tatatctatc atgtgatttt gttcttttta agctataatt 2715121 tagctatatc atgcaaaagg agcgatacga gtgatacgtt ttgcaataat aggaaccaac 2715181 tggattacag accgctttct tgagtcagca gcggatatcg aagattttca gctgactgct 2715241 gtttattcaa gatcggctga acgcgctggc gagtttgctg ctaaacacaa cgctgcgcat 2715301 gccttctcag accttcagga aatggcggcg agcgattgct ttgatgccgt atacatagcg 2715361 agcccgaacg ctcttcacaa ggaacaagcc gttctcttta tgaaccatgg caagcatgtg 2715421 ctttgtgaga agccgtttgc ttcgaataca aaagaaacag aagagatgat ctcagcggct 2715481 aaggcaaacg gcgttgttct catggaagca atgaagacca ctttcctgcc gaatttcaaa 2715541 gaactgaaaa aacacctgca taaaatcggc actgtccgca gatttaccgc aagctactgc 2715601 cagtattcct cacgatatga cgcgttcaga agcggaactg ttttgaatgc gtttcagcct 2715661 gagctttcca atgggtcatt aatggatatt ggcgtctatt gtatttatcc ggctgttgtg 2715721 ttgtttggcg cgccgaagga tgtaaaagca aacggatatg ctttatcctc cggagtggac 2715781 ggagaaggaa ctgtcattct gtcttacgac gggttcgaag ctgttctgat gcattccaaa 2715841 atctctactt cctatgcccc ggctgaaatc cagggtgaag acgggacgat tgtaatcgat 2715901 acgattcacc ggcctgaacg tgttgaaatc cgctaccggg acggccgcct tgaaaacatc 2715961 gcgatccctg atcctaaacc ggcgatgttc tatgaagcag aagaatttgt cacgcttata 2716021 aaagagaata agctggaatc tgaagaaaat acatttgaac ggtctttgac caccgcaaaa 2716081 attatggaag aagcaagaaa gcaaatgggg attgtatacc ctgctgatca agcttaaaaa 2716141 aatccgcccg cgtgcaaatg ccgcggcgga ttttttatta gacaatcgga gaagatgcct 2716201 tcctttttaa aagcacctgt tgctcatatt ctttgatgtc ataaagccat gcctctttta 2716261 ccggaacgcc catttgctca cagtaggaat cccagatggc tccgaaagga tatgttttga 2716321 attcctccat cagggccagc ctttctgtat agcggccctc ttcctgcaat tgttttaaat 2716381 atccgttcgg gagaagcagg gcatacaata aagctttgat catatttctc gttccgatgg 2716441 tccaggcggc tacacggtta atgctggcat cgaaaaaatc cagaccgatg gctaccttct 2716501 caagagcatg atttcgtaca atttcaagag cgatttctct caattcatca tccaaaacca 2716561 ctacatggtc gctatcccaa cgaacaggcc gcgatacgtg caaggcaagc ttgtctgtgt 2716621 aaagcagcat ggacgagatc ttgtttgata ccgtctcagt cggatggaaa tggcctgtat 2716681 caagtaaaca aagcttatga ttcgtcaaag cataagctaa ataaaattca tgagatccga 2716741 caacatatga ttcggagcca agcccgaaca gcttgctctc gattgaatca agattatgtt 2716801 gttcactgat ctcctctgag aagatccgat ccagtgattc ttttagtctt ttacgcggtg 2716861 tcagcctatc actcgggata tccttatagc cgtcgggaat ccaaatattc gtcaagcaag 2716921 gtgttcctaa ttctttcccg aagtattccc cgatacggcg gcaagcgatg caatgcctga 2716981 tccaaaattc tctgatgtcc ggatcagggt gtgaaagggt gagtccgtca gccgctttct 2717041 catgcgaaaa caaggttgga ttaaaatcta aaccgagacc aaggtttttt gcccatttca 2717101 cccagttttc aaaatgctgc ggcttcaatt cgtcacgttc taccgcttcc ctgtttgttt 2717161 ctgcgtatat cgcatgcagg tttacgcggt gctttccagg aatgagagaa agagccttct 2717221 ccaaatctct tcttaattct tcaggagttt gcgcttttcc gggataattg ccggtcacgt 2717281 caattccgcc tgaaagctcg cccttattta cttcaaagcc ttcaatgtcg tcaccctgcc 2717341 agcagtggat cgaaatgggc acttgctcta attgccgaag cgcctcttca acatcaattc 2717401 cccatttttc atatgcctgt tttgcactgt cataattggc ttttatggtc atacggctct 2717461 ctccctttat cagtttttca atccaaataa aaaacttcct ttagatctat cgcaacagga 2717521 ctgaaatccg aatttgtttt cattaatggc gccatcgatt tccaccatct ttggcaaact 2717581 tccgtgtccg ccatctttct ccatttctct tcatcctcta tttctaaata tgcaaaaagc 2717641 ctgcctgttt cctcgtctag aaaaatggaa taatggtgtg ctccatgagc tttgagtgct 2717701 tctgccatct caggccaaat gtcatcatgc cgctgtttgt attcttcgta cttgtcttga 2717761 tggacaaaca tgatactggc ttttcttttc aaaccttttc acctcttcat catttagata 2717821 gcgctttcaa aacagtttgc tgaaatgact gaatgatcgt gcttctatca atgtctttag 2717881 gtgtaaacac tttgatcgga aaggaatttc tgacgacttg ccgggcttct tttatgtctt 2717941 tgacttcttt ggcagcaatc atttgcatca aaagatttcc ggtggcagtt gcctctatcg 2718001 gccctgcata taccgctttt ccactcatgt ctgccgttaa ttgatttaag aaatcattcc 2718061 gggctccgcc gccgatgata tgaaattgct cgatcggttt ttctgtgatt gtttcgagct 2718121 ctttgatggc tatcgcatag atgatggcta aattgctgta gatgcagcag gcaagttcgc 2718181 ctgcagtacg gggaatcttt tggcgggttt gtctgcaata atgttgtatt tcctttatca 2718241 tgttttctgg attcaggaaa cgtttatcat ttaagtttat aaattgctgg aatggttctg 2718301 tttttttggc ttcttctgca agctgctgaa aagaataatc tgcttgtagc tgctgtttga 2718361 cttcttgtat cacccacatg ccgataatgt ttttgagaaa gcgaatggtg ttgtttgcgc 2718421 cgcgttcatt tgtatagttg ttttctaaag caagatcagt tattatcggt gttttgtttt 2718481 caaccccgat taacgaccat gttccgctgc tgatatacgc ccagccatca tttacgcctg 2718541 gcgccgcaat gacggccgag gccgtatcat gtgttgcgac tgtcatcacc ttgcacgccg 2718601 ggagatcata atccgggaac cactcatttc ttagcttccc gagttcacac cccggttcag 2718661 tgagcggcgc aaattgctgt tccagaacag acacggcttc aagcaattca ggatcaagat 2718721 ttcccgttga gacgtttaaa agctgtgttg tggacacgtt tgtgatttcc gttacagctt 2718781 ttccggttaa acaatagcct aaataatcag gaatcatcat aattttgtct gtctttttca 2718841 gcagctcacg gtcttcttca aacaattgat agatcgtgtt gaaaggctga aattgtattc 2718901 ctgttttttg ataaattgcg gcttttgaga gggtatgttc cagtttgtct attgtgtgat 2718961 ctgttcttct atcacggtag gagattgctt cccgcaaccg atcgcctttt tcgtccagta 2719021 agacataatc gactgcccat gtatcaatgc ctacggtgca gtgttcatac ccaagcgtct 2719081 ttactttttg cagtccttgc aggatttgtt ttagcaaatg atcaatatcc cataagcaat 2719141 gcccgtctct ttgactgaaa ccgttagcga acctgtgaat ctcttgtatg tcaagcttcc 2719201 cttcattcag ttcacctacc atgattctcc cgcttgatgc gcctacatca atggcagtat 2719261 aaatcatcct ttcaccctct cttcgaaaga ggaacagctg tcaccttcac ctttttgtcc 2719321 tcaagagctt ttaccgatgc cggatcaagt ccagaatccg taataaggcg gctgacatct 2719381 tgcagcgagg cgatatgtga aaactcgcgg ttcccccatt tgcttgaatc ggccatcaaa 2719441 atggtctggt ccgacctttc gatcatccgt tttttgagca gcgcctgcca ctcatttgaa 2719501 tcactcatcc cgttgtgtac gtcaaatccc ttacatgaca gaaaggtttt attgacatga 2719561 taggtctcaa gtgaacgctc tgctaacggg ccggcaaatg ataatgattt ttccagcaaa 2719621 atgccgcctg ttgaaatgac tgatatgttt tctttattgc tgagttcaat agctgctttc 2719681 attgagtttg taatcacggt gagctcaatg tcagggagta tttttgccat gtaccaagcg 2719741 gttgtgcttg catcgagaat gattcggtct ccgcttttta catatttggc cgcttcgtga 2719801 gcgatggctt ttttttcgat gacattcgtg atttcccgtt cagaaaaatg aatttctgat 2719861 tccttctgct gaatactgac cgctcctccg tggctccggc tcagtttatg ttctttttca 2719921 agcttttcaa gatcacgccg aatggtttcc tctgtgactg aaaaaatgtc acttaattcg 2719981 gaaacgcgga tgcttgaacg catatttact atttccacta ttttttgctg ccgttctgct 2720041 actagcatcg gtaacgccct tcctcatatc gtagtccgtc ttatattttt atcatagcat 2720101 atatctaacg cgtaaaagca gcagggacgc cgccgtctac cgtgatcatg cagcccgttg 2720161 ttttttcggc tttggaagaa gcgaagaatg caatggcttc ggcaatatcc tccgggtaaa 2720221 tattgacgag caatgctgtc cgtttccggt aatgttcctc cagctgatcc ggttcaatcc 2720281 cgtacgccgc ggctcgttcc tcacgccagc ttgaacccca gattgccgat ccttgaagaa 2720341 ctgcatcagg caaaacggag ttgaccctaa tgccgaattc tccgccttct gctgcgatgc 2720401 atcttgctaa atgggtttca agcgccttaa cagagctgta ggcagaggcg ttttttcccg 2720461 cataaactga atttttcgat ccgacaaata ccatgcttcc gcctctattt tgatgtttca 2720521 tctgtttaaa cgcttcacgg gctacaagga aatagcctgt tcctaaaaca ttcatattaa 2720581 gattccattc ttttagactt gtttcgtcaa atgggcttga tgtggccagc ccggcattat 2720641 tgacgacgat atcaatgccg ccgtaagcaa gcgccgctcg ttcaaaagct gactgtacgt 2720701 cttcctcctt tgtcacatcc attttgacag ccattgcccg tccttttccg tatgcatcgt 2720761 ttatttcccc ggcaattttc tgtgcgcctt ctatattcag atcagctacg atcacgtgcc 2720821 ctccctcagc tgcaaatcgg cggcatgccg cactgccgat tccgccggct cctccagtta 2720881 tcagcgctac ttttcgggaa aattctgctt ccggcggggc cagcgtgagt ttatatagtt 2720941 cgagcggcca atattcgaca tggtaggact cattttcatg taaagaaaca aattgcccca 2721001 gagcggttgc tcctttcatt acggcgatgg ccctccgata taaagccccg cttactttag 2721061 acatcgcata actttttcct gtattcacca ttccgattcc aggaatcaat atcacccgcg 2721121 gggcggattc aaagatttga tccccatcct gctgattgcg tgtaaagtaa gcctgatact 2721181 ctgatgtaaa ggtctcgact cctgacttga tcagatctgc aagcttgtgc acatcttgag 2721241 tttccggatt ccaatcaatg tacagcggaa cccgttttgt gtgaacaagg tgatccgggc 2721301 atgccgcacc gatttgcgaa agtgctggcg cttggacact gtttacaaat tccaagacat 2721361 cgtcatgatc atcataggaa aggatcattt tcttttcttc acttactgct cctctgatca 2721421 caggcatgat gcctgccaag atttgttttc ttttatcctc cggcagcggc tgataccttt 2721481 tgcctccgaa tacctcatgc tgattgatac gatcgttaat atactgctcg gcttcttgaa 2721541 tgatggatat cgttttttga taacatgttt cagacgtctc tccccaagtg actaagccgt 2721601 gtttctccat taatacaagc tcggcgtggg ggttgtttgc tacgccttca gcgatcattt 2721661 tagacaaagt aaatccagga cggacgtatg gcacccatac aaaccgattt ccgtaaatgt 2721721 cttcagcgat ttgttttcca ttatccgcac agcatatgct gataatcgca tctggatggg 2721781 tatggtcaac atgtttgtat ggcagaaaag cgtgtaatag cgtttcaatt gaagggcggg 2721841 gatgtttgct gtctatcata caatgagaca ggtagtctac catttcttca tcgggcattt 2721901 ggtccctttt aatcagcggg cggatatcat ctaatttcaa accggaaaag ttatgcgctt 2721961 tcattgttgc caaatccgat ccgcttcctt ttacccacat gacttctatt tcacggcctc 2722021 taaaatcctt ttccgttgtt ttcatagatg tattcccccc gccccagttg cagacagtgc 2722081 ggtctgaccc gatcagattg gacctgtaca ccaattcctc tacaccttta ggtagctgtg 2722141 cagctcgctc tgaatcccat atatgtttca ccatatttga tattcctcca taccctttta 2722201 tttgtatccg ttttcattat atatgatttc tgtttgtttt tgaatcgttt ttgtttattt 2722261 ttgcttttta acaaaaaaag aaagcagcag atatgccgct ttctcgtttc attatgattc 2722321 tattttaaat ttcttcgtaa tgtcctgaag ttcttccgcc atgtttgcca acgtttccgc 2722381 tgaagagctg atttcttcca tggacgcaag ctgttcttcc gccgaagctg cgatatcctg 2722441 aatgcctgct gagctttctt tcgccactgc agaaatatct tcaacagcac ttgacacttc 2722501 ctgtgatccg gctgacagtt gttcaaccgt cgcgttcaag ttttgcaatt cgccggaaat 2722561 ttgggttgtc atctcataga tttgtttaaa gctttccgct gtttgatccg taatctgcaa 2722621 gccttctttc acttcatgat tcacggattg gaacattgaa agtgaggtgc tgatttccct 2722681 gacaatctct tgaattaatc cttcaatttc cttggcggag tctgctgatt gtacagcaag 2722741 ttttctaacc tcttccgcaa ctactgagaa acctcttccg tattctcccg ctcttgccgc 2722801 ctcaatcgca gcatttaatg caagcaggtt ggtttgatca gcaatgccgt taatcacatt 2722861 caagatgctt gtgatgtctt gcgattttgt ttcaaggccc ttcacaaccg cttccgcttt 2722921 ttgaacggat tggtcaattg ttttcatctg gccgactgta tgctccacca gcttttctcc 2722981 gctgcccgct gcctcagagg actgaatcga tgatttcgta atggttgaag aggcttgagc 2723041 cacttttgaa atcccctcgt tcatttgaga aagatgattt gagcttgttt ccagtttctc 2723101 gctttgtgcc tcgttgccat ctgagaactg ttcgatggca agtgtaatat gttcagttgc 2723161 cttgcttgtt tgggctgcgc ttgctgtcag ctcctcagaa gatgaagcga cgttttctac 2723221 agacgtttga ataacgccta ttacagaacg caatgatgca gacatttcat taaagctttc 2723281 gccaagctgg ccaaactcgt ttttcgagtg aatgtcaatg acttctgtga gatctccgct 2723341 gctgattttt gcagacgttg agacaagttt tcttaacggc ttggtgatgg cacggataat 2723401 atagagtatg agtatgccgc cgattactat tgacacgcat agaatgataa ccgcagtgtt 2723461 cagcaccggg cttgaagcat cttgcaattc actgacaaaa tatgtgcccg cgattttcca 2723521 gccagtcagt ttatttgtcg taaaggccat tttcttttct ttgccttcga atgtatattc 2723581 aaatgagcct tcttttttgg aatatacttg gtttgtccaa tcgccggaac cggttgtccc 2723641 cggcttaatg gtcggatggg cgatatattt tttgttgcct gtcgtaataa atgcaaagcc 2723701 ttcttttccg attttgattc tttttgatgc agtaagcact tcatccaggt ttaaatctag 2723761 cgctataacc cctgaaccgt cttttaattg ttttgaaatt gtgacaacga tatctcctgt 2723821 cgcttcatcg gtatacggtt ctgagaaaac agcttgtcct ttttccgcaa ccgcctgttt 2723881 gtaccagtca cgtcctgtcg gatcgaaacc tttcggaaca ccgctatccg gatatttata 2723941 aagcttctta tcttctgagg cagcatagat tgcgcctaca tcgtcgttaa gtgtcgtgta 2724001 ctgcttaaat ttctctttca gtaatgtttt gtttttgcct aacaatatgt ctttatcgac 2724061 tgtctcacta taataatcta ttgcttttac tttatcttct aatttatttt gcagcgtact 2724121 gtttagttct tcaacatttc ccttcgcact gcttatgagc tctctgtcta acgcgttcca 2724181 agctgattga taactgaaat atgctaaaac cccaaccggc aaaataagca ctgccagaaa 2724241 cgcagcgatt agcggtttgc tgatcgatgg ctgtttgatc cattgtatga attttcccat 2724301 tctcgttgac tcctccttta agataaatct aatatcgtca aactaggata aaaggtttaa 2724361 taaaaaaact aaaaaaaaca cccaagcgca acaagcttgg gtgttaaggc ttattattca 2724421 attttaaatc gtttggtcat atcccgaagc tcttccgcca tagaggaaag ggtctctgca 2724481 gacgagctga tttcttccat ggaagctagc tgctcttcag ctgacgccgc gatatcttgt 2724541 atatgcgctg agctttcttt tgaaatcgat gcaatgtgct cagacgctcc cgaaacttct 2724601 tcggagctgg cagaaagctg ctgaaccgtc gcactcatat tttgcagttc gccggcgatt 2724661 tggttcgtca tttcagaaat gcgtttgaag ctcatttctg ttttatctgt gatgtcaagt 2724721 cctgtctgca cctcttgatt gacagattgg aacatgccga gtgatgtatt gatttccttc 2724781 acaatttcga tgattaatcc ttcaatctct tttgctgaat ctgctgactg tactgccagt 2724841 tttcttactt cttccgctac aacggagaag ccgcggccgt actcgcctgc gcgcgctgct 2724901 tcaattgctg cgtttaaggc aagcaggttc gtctggtctg cgatgccgtt gatcacacgc 2724961 aaaatgtttg taatatcttt cgatttcgtt tccaatccgc gtacgacttg ctccgcttct 2725021 ttaacggact tgtcaatgac attcatttgg ccgacggttt gatgaacaag cttgccgcct 2725081 tcacttgcaa tttctgtcga ttgaacagat gaatcagtga tcacttcaga agcttgagcc 2725141 atattcgtca acccgtcatt catttgataa atgtgctctg ctgccgtttc aatgttttcg 2725201 ttttgttttt cattgccgtt agaaaattgt tcaatcgcca atgtaatgtg ctctgttgcc 2725261 ttgctcgttt gcgcagctga tgcagtcagc tcctcagagg aagcggcaac attgtctacc 2725321 gaatcctgga tggcgtgtat gagagaacga agtgacgacg ccatattgtt aaagcttttg 2725381 ccgagctcgc ccaattcatc ttttgaacgg atatcaatgg tttccgtcaa atctccctcg 2725441 ctgatccgct tagaggaacc gacaagctgt ttcagcggtg ttgtaatcga ccgaatgatc 2725501 aatgtcatga cgataatccc tatgataata gctgcggcca agacaattaa agcaaggtga 2725561 aggacaggct gggctgcctc atggatttca tccaaataca tggtgccgcc gatcttccat 2725621 cccgtcaact tgtttgtgtc aaaggccatt tttttcttat cgccatccat ggtgtattga 2725681 aaatcgcctt tatcagcact caacatctta tcgagccagt cgccttttaa ttcagttcct 2725741 gattgttcat tagggtgtgc gacaactttt ttgtccttcg tcatgataaa tgcgtagcct 2725801 tgtgtgccga tgttgacttt tttggttgtt ttcagcagat tttcaatcgt catgttgatt 2725861 gcgataacgc ctgaaccatc ttttgtctgc tgggcgattg tcacaaccat cgtatttgtc 2725921 gacgcggttt tataagggtc tgtgatcacg actttccctt tatttgcaac cgcttttttg 2725981 taccagtcgc gttcaaccgg attatagccg cttggcatcg gaagatccgg atagcgggta 2726041 aagtgccctt ttgtgtcact tgtataaatg gattctacat ccttgttaat gctgatatat 2726101 tgtgagaatt tctctgcaat gcttgcattg ctttttgcat tgtatttctc ttttgtcagc 2726161 cattcgctga aataatcagc actgttttct ttttcgccga tgctggtgtt aatgatttcg 2726221 tttaattgct gtacattttc caatgcgctc cccatcatct gtctgtcgag tgagctgcta 2726281 gccgattgat acgcaaagat cgccaatatg acaaccggta tgatgaggat cgacagaaag 2726341 gaaacgagaa gcttccgtgt aattgatctt tgttttatga gttggagtat ttttttcatc 2726401 attcatttct ccttttttat gctacccttc atatcggctg gaaatgggta aatatataca 2726461 gcaaaaaaga agaaatttaa caaaagtaac taatttccca taaataaata gtattttaga 2726521 cctattattt gtctacttta aattgttttg tcagatcacg gagttcttca gacattcttt 2726581 caagcgtcag tgcagatgaa ctaatctcct ccatggatgc cagctgttcc tcagctgaag 2726641 cggcgatatc ttggatgcca tccgagcttt ccttagaaat ggcagtgata tcatttgaag 2726701 ctgcggaaat ttcttgagct cccgctgaca gctcctcaac cgtcgcattc atgttttgca 2726761 gctcggaagc aatttgattg gtcatttgcg atatatgttt gaagctctgt ttagtttcat 2726821 ccgtcatgac aagccctgtt tcaacttctt tgtttacgga ctgaagcacg ttcagtgatg 2726881 tgtgaatttc ttttactatt tcactgatca gcgattcaat ttcttttgct gagtcagccg 2726941 actgtaccgc gagctttctc acttcctcag cgacgactga gaagccccgg ccgtattcac 2727001 ccgctctggc agcttcaatg gcggcattta aagccaaaag attggtttga tccgcaatgc 2727061 cgttgatgac acgcaaaata ttcgtgatat cctttgattt gatctccagc cctttcacca 2727121 cttgttccgc tgcttttacg gaatggtcaa ttgtgttcat ttggccggct gttttctgga 2727181 cgagtgtctc ccctttgctt gacacttcgg ttgaatctgc ggatgtttct gtaatcactg 2727241 ctgcagcccg cgccagctct gccaatccgt cattcatttc attaatttgt tcggttgtcg 2727301 tttctatttt ctcgctttgg ctttcactgc cgtttgaaaa ttgctcgata gccatcgtaa 2727361 tgtgctcagt ggctctgctt gtctggtctg ccgatgcagt cagctcttca gacgaggagg 2727421 caacgtgttc tactgagtct ttgatcccgt gaatgagcga gcgaagcgag tgtgccatat 2727481 gattgaagct ctcactcaga acgccgagtt catcttttga attgatttca atcgtttcgg 2727541 ttagatcgcc ttcactaatt ttttcagcgg atgcgacaat gcgtctcaat ggctttgtga 2727601 tggatcgaat cacaaaataa atcgccgtca ttccagctcc gatggcaatc gccagaacga 2727661 ttgaagccat gatcagaacc ctgcttgcag catcgtgaat ctcgtttgca tacatcgtgc 2727721 cgctgatttt ccagcctgtt gtttggcttg ttgcaaatgc catttttttc tttttgcctt 2727781 tgtacgtata ttcaaagtcc ccgcttttat ccttgtagag cttatcaacc cagtcccctt 2727841 ttagctctgt tcccgctttt tctccggagt aggcgatgac tttcttgttt tggctcaaaa 2727901 taaaagcata gccttctttt ccgatattga ttcctttcgc ggtagtgact aagtcatcaa 2727961 ttttcatatc aatggcgaca acgcctgacc catccaccgt ttgacgggcg atggtgacga 2728021 ccatttttcc tgatgaaatc gattcataag gctcagtgac aattgttttg cctttattgg 2728081 ccattgcttc tttgtaccaa tctcgttcca aagcattaaa gtcgcttggc atgtcagcgt 2728141 acggataacg tgtgaagtcc ccgtctttgc cgcttgaaaa taccgcagcg acattatcat 2728201 tcatttggat aaattgttta aattcctgtt tcagctctgt tttcttttta tcctgaaatt 2728261 tttctgctgt agcccaatcg ctgaaatatg cgaggctttt ttcagtagtg ctgattttat 2728321 catcaatgat gtgatctaat atctgaacat tttcctttgc gctttgcgtc atctgtacat 2728381 caagtgaggc aactgctgat tgataagcgc taaccgaaag ggcggttatc ggaacaatta 2728441 agatcagcag gaaagaaata ataagtctcc ttgcaattga tgatctgcga atagtggtga 2728501 gtgttttttt catttccttt tgaaccttct ttcaataatt tacaaattat atcggcggat 2728561 cttcctttaa attacattga aaatggagga aaaaatgaaa aatagttcta aattcacctg 2728621 ttaaactagg actttattat tgtttaccat ataaaaaaac agcgctttga tagcgctgtt 2728681 tttcggtttt tactcgattt taaattgttt cgtcagatcg cgaagctctt ctgccatctg 2728741 cgcaagagtc gtcgctgagg aactgatttc ttccatggaa gcaagctgtt cttcagctga 2728801 tgcggcaatg tcctggatgc ttgccgagct ttctttcgac acgtctgcaa tgccgctgac 2728861 tgctgctgaa acatgctgtg aacggtctga cagctgctcg acggtggaat tcatcgtctg 2728921 cagcttgccc gcgatttcgt ttgtcatgct gaaaatgctc tggaagcttt cttttgtatt 2728981 gtctgtgaca acaagtccgg actgtacttc ctgattgacc tctttaaaca tgtgaagaga 2729041 ggtgtcgatt tctgcgacga tttcttggat cagcttttcg atttctttcg ctgaatcggc 2729101 tgattggaca gccagcttgc gcacctcctc cgctacgaca gagaagccgc gtcctgactc 2729161 tccggcacgc gccgcttcaa tggctgcatt tagtgcaagc agatttgttt ggtcagcgat 2729221 tccgttgatg actctcaaaa tgcttgtgat gtcttttgat tttccttcta agcctttgac 2729281 aacagcttca gcctgctgaa cagattgatt aatcgagttc atttgtccga ctgtctgctg 2729341 cacaaacttc tcacccgttc cggcgatttc cgttgattgg atagatgcct ttgtaatatc 2729401 tgacgatgtt tgtgagactt gctggagtcc ttcattcatt aagttcagct gatgagagct 2729461 ggattcaacc ttttcgcttt gctcctcgtt tccgtttgag aactgctcaa tcgccatcgt 2729521 aatatgctcg gtggctttac tcgtctgccc ggcagatgcg gtaagctgtt cggaagatgc 2729581 ggccacattg ttcaccgagt cctgaatagc gctgatcaga gagcggagag attgtcccat 2729641 ttcattgaag ctttccccaa gctctccaag ctcatccttt gaatggattt cgatcgtttc 2729701 ggtcagatcc cccctgctga tcgttttcga tgattgaaca agacgtttta acggttttgt 2729761 aatcgaacga acgataaaca gaattaaaat tccgcctgcc acaatggaag caatcagcac 2729821 aatcattcct gttgtcagca cagactttga ggcatcctta atttcatcca tatacattgt 2729881 gccggctatt ttccaaccag tcagttcgtt tgtagtatag gtcatctttt tatcttcgtt 2729941 attaagagta tactggagtt caccgctgtc attcgcatac attttggcta cccagtcgcc 2730001 tgaaagcttt tctccagcct tatggttctt gtgggcgaca taggttttgt tttttgttgc 2730061 aatgaaagca taaccttctt ttccgacctt gatttgtttc atttgttcta acaatttatc 2730121 aatggtaata tccatggcga caacgccaga tccgtccttc agctcctgtg caatggtaat 2730181 gaccatgctt ccgtcactcg cagccacgta aggatctgtc acgacaattt caccgccggc 2730241 cttcatcgca tcctggtacc aaggccgttg tctcgggtcg tatccttccg gcaatttttc 2730301 ttttggcgct tgtacataag tgccgttatc tgcgccccca taaattctgg ctactccttg 2730361 attaatagat acatattgtg aaaatttagc tttgatctct tcttgatttg atttcccttt 2730421 gaatgcggat cttttaagag attcactgaa aaaggtgact gctttcgctt tttctcccag 2730481 atcatttgta acagttgtat taaatgtatc gacactgttt ttcgcatttc ccataatttc 2730541 ctgatccagc tttccgctgg cgcttcggta agagctaaat tctaatataa gaatagggat 2730601 aatgagaatc gcaataaatg agacgattaa tttctttgaa atagacggtt tcttcagcca 2730661 attgataaaa gtcttcatgt cacttgctcc ttcaggtttg atacagtata tatcggctgc 2730721 ttaaaaaagt tttaaaataa aaaatggaag aagttctttt tggctgtctt ctgccttttt 2730781 aactttcatt gcccaagctc tttgcatatc ttataaaaaa caaggggggc taaacatgat 2730841 tattgtatca ggacaattgc tccgtcccca ggatattgaa aattggcaga ttgatcaaga 2730901 tctgaatccg ctcttaaaag agatgattga gacgcctgtt cagtttgatt atcattcaat 2730961 tgctgaactg atgtttgagc ttaaactgcg gatgaatatt gtagcagcgg caaagacgct 2731021 gcacaaaagc ggggcgaagt ttgccacttt tttaaaaaca tacgggaata caacgtattg 2731081 gagggtttca ccggagggcg ccttggagct gaaatacaga atgccgcctt caaaagcgat 2731141 tcgggacatt gcagagaacg gcccgtttta tgcgtttgaa tgcgcaaccg caatcgttat 2731201 catttattac ttggccttaa tcgatacaat cggagaagat aaattcaatg ccagctttga 2731261 cagaattatt ttatatgact ggcattatga gaaattgccg atatatacgg aaacaggaca 2731321 ccactttttc cttggagatt gtttgtattt taagaatcct gaatttgatc cgcaaaaggc 2731381 gcaatggaga ggcgaaaatg tgatactact gggggaagat aaatattttg cccatggtct 2731441 tggaatctta aacggaaagc aaattattga taagctgaat tcttttagga aaaaaggagc 2731501 cttacagtca gcctaccttc tgtctcaggc gaccagactg gatgttccgt ctcttttccg 2731561 catcgtccgc taaaaagccc catcgcctat tttccggacg atggggtttc aaatgccttt 2731621 cgttttcgat agaagggggc tgtgccaaaa tattggttcg cagcccactc cattttttca 2731681 aggtcatttc ttgtcacgat tggatcctgg ctgctccatt tgataaagcg gacaaaatag 2731741 tagcctttga taggaaccat tgtaactttt gagtgaggcc agccttcaaa tacaaactca 2731801 attttccctc tttttttata agaatattga agaatgttca tatctgtcac ctcagtttat 2731861 caagttacgt tcggcaaagc tcggtacgtt tacatccatt gattaactat ccctcatgca 2731921 ggctttccgg aaaacaaagg gtgaggcgcg tgtctctttc cctcgctttt tatttcgcat 2731981 atggacgaat gccaagcacg ccttcattcg ataaagccgc agcgtgggcg ggtgtgacaa 2732041 gccctccggc tatcggcgct tgttcagcga tcatgctttt gtcataaaaa acagcctatt 2732101 atcccatcat tttgatatag catgtccggg tgcgaggccc gtcaaattcg cagaaataaa 2732161 tgccctgcca cgttccaaga ataagccggc cgttttccac aatgacatgc tgtgaagctc 2732221 cgaccgtact cgacttcatg tgtgcagctg tattgccctc catatggcgg tccagctcat 2732281 gttcccacgg atatacctca tcaaaccttc tgagcatatc ttttttgacg tccggatcgg 2732341 cattttcatt aattgtaatg cccgcagtcg tatgcggaca gtaaatcagc gctgcgccgc 2732401 tcgttatacc tgtttcttga agaaacgctt ccacctcccg ggtgatatct atcatttcat 2732461 ctcgtttggt tgttttgatt tgcagtgttt tcagcatttg tttctccttt cgtttgtccg 2732521 ctctcatcgc ttaattcgtt ctgtgttctt ttttttcctg ttaaaccgct ctcataaacc 2732581 cgataaaaca aaaaaactcc agtctaaggc tggagtttag caccatagat atattcttgc 2732641 ttcatacggc tttaagagta ctgatgtcat atgcttgtgc ggctctgttt caatatttga 2732701 caagacgagt gcatctgatg acaatggcaa tccagagtgc ctgaacaacg ccggtgttcc 2732761 tgtcagattg gccgcaatca gtgcagtatg gctctcgttt ttccgaagat atgcaaagat 2732821 ttgctgatct tccggtaaaa tgagctcgta tgtcccgtta ataaaaacat catatgtttg 2732881 gcgcagcttg atcaagcttt tgtaaaaatg gtaaacggat gttttatcgt ttttttgcgc 2732941 ctcggcattc agccatttgt aattctcatt gattccgatc cacggtttgg cctcagaaaa 2733001 tccggcgtat ggaccagcat tccattgcat cggcgttcgc gaattgtctc ttcccttttt 2733061 ccagacaatc ttcatcacat cctcgtgtga tgtgcctttc gctgtttttg tttcatacag 2733121 gcgtttcaat gcgacatcat catagtcctc aatagatgga aaagccacgt tcgtcatccc 2733181 gagttcctgt ccctgataaa taaacggtgt gcctttcatg agaaaataaa cagcggaaag 2733241 cgcttttgca ctttctttca ggtacactcc gtcgtctccc cacacagaaa ctgaacgggg 2733301 ctggtcgtga ttctccataa acaaagcatt ccagccgatc ccttccagac tgtcctgcca 2733361 gtcagttaaa attcgtttaa atgcaacgat atcaatactt tcattgatct ctacatccca 2733421 caggccgaga tgctcaaatt gaaaaatcat gctgaatatg ccgttttttt ctccagccca 2733481 atcagctgct tcttttgcag cgacgccgtt tgcttcacca actgtcataa tcggatagcg 2733541 ggaaaatgtg ttttccttca gctctgttaa caaatccata atgccgtcag cattcatatg 2733601 ataaggaaag gaagggacat agtccagtcc ctttggattc ggcatgtcag gaaacccttc 2733661 ttttttctta atatgcgtaa tggcatccac ccgaaatccg tcaattcctt tatcaagcca 2733721 ccaattgatc atgtcataaa cggcattcct caccttttca ttttcccaat tcaaatcagg 2733781 ctgtttttta tcaaaaaggt gcagataata ctggcttgtc ttttgatcat actcccaagc 2733841 cggcccgccg aaaatgcttt cccaattgtt gggcgttttt ccgtttttgc cgtctttcca 2733901 aatataccag tcgcgctttt ccgagtgtat ggatgaacgg gattctatga accatggatg 2733961 ttcgtcgctt gtgtggttca caacgagatc cataatcagc ttcatatcca gatcatgaat 2734021 gtcaccaagc agctcatcaa aatcttccat cgtgccaaac tcgcttaata tgttttgata 2734081 atccctgata tcatagccat tatcggcatt cggtgaatca tacagcgggc aaatccatat 2734141 gacgtcagcg cccagctctt ttatgtaaga aagcttggtt ctgattcctt gaatatcccc 2734201 gattccgtcg ccatttgaat ctttaaaact gcgggggtaa atttggtaaa ctacggcttc 2734261 cttccaccaa gcctttttca tacagccact ccttcccagt gtaccgttct tatatatcct 2734321 atgtagaaaa aggtctttac agcattgctt tttaagaaat gacttgatga cacaaaaaac 2734381 agccgtttgt tccccggctg ttttttatca aaaatcagtt ttttttattt ctacaaaacg 2734441 gatgtggtga tcttcggcgt cgaggatttt aaattcacag ccctccgcgt gtatcacatc 2734501 ccctgctttc agctccattt tttgcgttag aagccagcct gcaatcgtat caatttcttc 2734561 attttcaatc gcaatgtcga gaaggtcatt cacttcgtct attagcgctt ttccatccat 2734621 cacataatgg tgctcgccct ttttcaggat gtgcggtgtt tcatcctgat catactcatc 2734681 gcggatttcc ccgacgattt cctcgataat atcctctaca gtgacaagcc ccgccgttcc 2734741 cccgtattca tcgacaagaa tcgccatgtg aatccgctcc ttctgcatgc ggattaaaag 2734801 ctgctgaaca ggaatgcttt caatgactct gataacgggc ctcatgattt gattcagctt 2734861 tatcggctgg ccgagaaaat aagctttaaa catatctttg ctgttgatga tccctaaaat 2734921 atgatccttg tcatctttga tgacagggta gcgtgtatac cgttcattaa tgatgtgatg 2734981 aattgcctct tcaagcgact gctccagaga gataaccgca atttctgtcc gcggaatcat 2735041 aatctctctc gctacccggt tgtcaaattc aaaaatctta tttacatagc ggaattcaga 2735101 ctgattgatt tctccctttt catagctttc agaaaggatc agccttagtt cctcttcgct 2735161 gatgacaacc tgatgctcct ttaccgaatg aaagccaaac aatttcacaa gaaaacttgc 2735221 agagccgttt aatgctttaa taaacgggta cgtgatttta taaaaccaga tcagcggctt 2735281 tgcaatccat aagcttacag cttcagcttt ttgaatagaa accgttttcg gggcaagctc 2735341 ccccatcacc acatgcaaaa aagtgacgat gataaatgca actacaaatg tgacaatgtg 2735401 gttaaacggt tccggtatgc ctgtcattgt aaataaggga tgaagaaaac gttcaaatgt 2735461 aggttcacca agccacccaa ggccgagggc tgtaatcgta atcccgagct ggcaggctga 2735521 taaatactcg tcaagattgg agatgatttt atgtgcggct agtgctcggc tgtcaccgct 2735581 ttcgatgagc tgattgattt ttgaacctct gattttgacg atcgcaaatt ccgctgcaac 2735641 gaaaacagcc gtaatgccaa tcaaaacaaa aatggcgatc aattgtaaaa taagcaaaaa 2735701 aagcccttac cataaatggt aaggggccac ctccttaacg ttaattctca tcacgaccgt 2735761 ttaagaaaat catcacaaaa cgaagtagtt caaacaggga aaccagggcg gcggccacat 2735821 acgttaaggc agcagcactc agcactttat ttaccccatt ttcttcattg tttcggatga 2735881 atccttctga cacaataatc tgcttcgcac gtgaacttgc attgaattcg acaggcaatg 2735941 taatcagctg gaaaaagaca gccgctgaaa acagtatgat gccaagcccg atcaaattca 2736001 ggctgccgag aagcatgcct cctaagaaaa gcaaaggagc tacaccggat gcaaaattca 2736061 cgactgggaa gattttatgt ctcagcacaa gcgcaccata tgactcctga tgctgcaagg 2736121 catgtccgac ttcatgggaa gctacggata tggcggaaat tgagcggccg taatagaccg 2736181 gctcagataa acgcaccacc cgtcttgtcg ggtcgtaatg gtctgttaaa gtgcctctta 2736241 ccggttcgac cggcacgtcg taaagaccgt ttatatctaa aatccgtctt gccgtttctg 2736301 cccctgtacg tccgcttgag gcttccactt ttgaatattt ttcaaagttg ctctttactt 2736361 taaattgtgc ccaaaacgac aatcccaatg cggctattgt taaaaatata aacagcattt 2736421 tttcatcatc ctttgttcat gatcatttct ctattacgat tattttaatg agttttcttt 2736481 ctcgtgtaca gaaatgcgct ttttcttccg gcttggagca cacaatccaa tcagcaaaaa 2736541 gaacaggcct gctgaaaaca aataaaaggc gaaactgccg gccagttctt tcagaaaatg 2736601 aagccaggag aagcttccgg aaaagtgatt atatgaattc aaatcgaaaa taaacaaaat 2736661 caccgcggat gccgccagct gcgtaccgat taaaaccacg atcgttcttt gaaagatcgt 2736721 catctttttc atcctttttg ttttagttta tggagaaatc cggttttata tgttttgtac 2736781 attttttgaa aaacatcacc ggaagtggga catactgtta gaaaaaagca cgggtgtgat 2736841 ggaagctatg aaagtgacga gtgaggaaaa ggaacagctg agcacagcaa tcgaccgaat 2736901 gaatgaagga ctggacgcgt ttatccagct gtataatgaa tcggaaattg atgaaccgct 2736961 tattcagctt gatgatgata cagccgagtt aatgaagcag gcccgagata tgtacggcca 2737021 ggaaaagcta aatgagaaat taaatacaat tattaaacag attttatcca tctcagtatc 2737081 tgaagaagga gaaaaagaat gaaatcaaat cggatattta tttcatggct caggtggccg 2737141 ttatttatcc gaatcggggt tattatttta tgtctgattc ttttgttcgg ccaaatcatt 2737201 tatatacttg agcctaagca gttcacttcg gtattcgaag gtatttggtg ggctgtcgtt 2737261 acggtttcta cagtcggtta tggagactat gtgccgcaca ctccgctggg acaggcagcc 2737321 ggaatactgc tgattttgag cggagcaagc tttgtcacag cgtatttcgc tacgttatca 2737381 gcggccgcat tcagcagaca gcatcgctac attgaaggaa aagttgctta caaaggccgg 2737441 gaccacatca ttctgatcgg gtggaatgaa aaaacaaacc ggcttttgaa ggaccttcag 2737501 cttgccgccc cttccaaaac agtcgtacta atcgatgaat ccttaacaga aggcccgctt 2737561 attgaaaacg ttcatttcat acgcgggcac gctgccgatg atgggacact gaaacgggcc 2737621 aatattactg aagcggaatc agtgatgatt actgccgatc agtataaaag tgaaactgat 2737681 gctgatatgc tgtcagtgct gactctttta tctgttaaag gtcttaatcc ccttgcttac 2737741 tgcatcgtcg agattttaac tgaccgtttt gtcaccaatg cggaacgggc aggcgcaaac 2737801 caaatcatcg gaacttcaga atttatcagc cgggcgatgc tgcagcatta ccaagtcaag 2737861 ttacggccgt ctaaacagca gaacggaatc aagctgacac ttgatcagca tgtggagctt 2737921 cttgctgttc ctgacgaact aaagggagcg gcttacaaaa cctgtgttct ctatttcctt 2737981 gatcacaaca caacaattat aggcatacaa aaaaaggagg ggccgatgct ttcccctcct 2738041 cttacataca aggtgctcga aacagatcaa ttccttgcca tctagtgtaa cagaacatcc 2738101 tccaattctt tcacgagaga ggcgccgata tccaaaaatg ccggatcaat ttccgcgtcc 2738161 cgcctttccg gttcggaaaa ttgattaaac agtgattgga aaggccctcc ctcggcgtga 2738221 tcgtcaacat ccgcctgaaa cacctgtctc agcataaatg gcgttccgat ccggacggcc 2738281 gcccctcgtt catcgagact gccctgtacc gcattgacgg gaattcttaa aaataaatag 2738341 ccgtctctat catcaatttt ataatcaaag tagccatgat cgtattccca gccgccgttt 2738401 atcacataac cgagcggctt catcacttgt tccagttctt gaagcagaaa agactgccca 2738461 tctatcgcgg aaggtattgg tatcatcaga atgccccttt tttcacttat cctgtcccgc 2738521 cgaacaagac ttcattcaga ggcgcctaca tggaaatcgt tgtttctttc gcgcggccaa 2738581 caggaaagaa agcgcattca attaagaagt aaacagccat tgccgctgca agccatacag 2738641 ctgaatccca agacacataa acaaccgttg catagagtcc taatttagtg aaaagagtat 2738701 gggttcgttt taaatgcaaa atccgatgta ccgcatcggt aaaaagggca agcggcaaac 2738761 caatgagaag aaaggagtgg atgaaaaaat gtgacagcgt gccgccaaag cttgaagaaa 2738821 accctgtata cacggcatca aaggagataa ggaaacttaa aatagctgca gaaaaaccgg 2738881 caatgatgag atgtttaacc aattgtttca tgaacatcag cacctttctg attttataaa 2738941 aagccgaccg gcaaatgcca gtcagctttc tcacattaat cttccagacg tttttcaagc 2739001 tctgcttttt tctcttcaaa gccaggtttg ccgagtaacg caaacatatt gactttatac 2739061 gcttctacac caggctggtc aaacggattg acgccaagga ggtaaccgct catcgcgcag 2739121 gctttttcga agaaatatac aaggtatcca aaagtatatg cattcagctc aggaatgtta 2739181 acgattaagt tcggaacatt tccgtctgta tgggcaagca ttgtaccttg gaatgctttt 2739241 ttgttaacga aatcaacagt tttaccggct aaatagttca agccgtcaag atcgttatcc 2739301 gcttcctcaa ttgtcagttc atgtttaggc ttctctacgt tcaggaccgt ttcgaataaa 2739361 tctctgcggc cttcttgtac atactggcct aaagaatgaa ggtctgttga atagttcgct 2739421 gaagaaggat aaatgccctt ctcatctttc ccttcgcttt ctccgaacag ctgcttccac 2739481 cattccgcaa agtattgaag cgccggttcg tagttgatga gcatttcaat tgttttgccc 2739541 ttattataaa ggacattgcg aacaaccgca tattggtatg ctgggttatc ttccagttca 2739601 gatgttgcaa aatctttgct cgcatccagg gcgcctttca tcatgtcgtc aatgttgacg 2739661 ccgctgacag caatcggcaa gagacctaca gctgttaaaa ctgaataacg gccgccgaca 2739721 tcgtcaggaa ttacgaatga ttcaaagcct tcttcgttag aaagcgtttt taatgcgccg 2739781 cgctctttat cagttgttgc ataaatccgc gctttcgctt cttctttacc gtatttctct 2739841 tcaagaagct tgcggaaaat acggaaagcg attgcaggtt cagttgtcgt acctgattta 2739901 gaaatcacat taatagagaa gtcaacatct tcaagaagat ccatgacgtc tctcatataa 2739961 gatgaactga tgttgttccc gataaaaatg acttgcggat tgccgcgttt tgcttttggc 2740021 aaagtgttat aaaacgcgtg attcagcgct tcaatcgctg cccgcgctcc aagataagaa 2740081 ccgccgatgc cgacaacaag caagacatca gagtcagatt tgattttttc cgcgcttttt 2740141 ttgatgcgcg cgaattcttc tttatcataa tgttcaggga ggtccaccca gcctagaaaa 2740201 tcgctgcccg cgcctgtttt ctcatggata ttatggtgtg ctgtttttac aaagtcccgc 2740261 aggtatgtaa gttcatgttc gttgaagaaa gtcaacgctt ttgagtagtc aaagcgtaca 2740321 tgcgtcattg cttgtccctc cataacggta taatgttttc atctttcact ttatatgaac 2740381 ttatctgtga aatcaagtca agaagaaagg gcggaatgac tggattccgc cctttgggtt 2740441 tatagagacg cgcgaaggat ggcaagcacg tcatctttgt tcagtttttg gaagttgccg 2740501 aagccgccgt gttccatttc cttggctgcg atatcagcaa tcagctcaag cttttcttct 2740561 ccaatattgt aatcagcaag acgagaaggt gcaccgaggc ttgtccagaa cgcagacagt 2740621 ttatcgattc cttcaagcgc aatttcttta tctgttttgc cttcagtatc aatgtcaaac 2740681 atgttgagca taaggttttt aaaacggcct acatttgtat caagcgtgta tctcatccaa 2740741 tttgggaaca gtattgccaa accgcccgcg tgcggaatat catatacagc tgaaacagcg 2740801 tgttccattg tatgagaagc ccagtcaccg aagtatccca tttggagcgt gccgtttaaa 2740861 gcaatagtac cagcatacaa aatcgtttca cgaagttcgt agttttccag atcttcaaga 2740921 agcttaggag ctgtttcgat gaccgtctgc aaaacagcaa agcacattct atcctgaagc 2740981 ggcgtgtttt caacattatg gaagtattgt tcgaatacgt ggctcatcat gtcaaccatg 2741041 ccgtatactg tttgattttc tggaacggtg aacgtatttt cagggtctaa aatagagaaa 2741101 cgcggatgag tgacattgct gccccataca aatttctcgt ttgtttccca gtttgtaatc 2741161 acggaatcag ggttcatttc agaccctgtt gcagcaagag ttaaaacagt gccaaacggc 2741221 agcgcatcct ccgctgttac ttttttgctg aaaatatccc aagcgtcacc gtcatatttg 2741281 acgccagctg cgattgcctt tgtacagtca atcacactgc ctccgccgac agcaagcaga 2741341 aaatcaatgt catgctctct gcaaagtcct atgccttttt ccactgtcgc aagacgcggg 2741401 tttggctcta cacctgacag ctcatgaaca acagcgccct cttcttttaa aatgcctgtg 2741461 acttgatcat aaaggccgtt gcgtttaatg ctgccgcccc cgtaaacaag cagtacattc 2741521 ttgccgtatc gtttgaattc ttttcttaat tgttcaagct gaccttttcc aaaaatcagc 2741581 tttgtcggat tataataagt gaaattttcc atagtaaaac ctccaaatga tgctggtaaa 2741641 aaacagattt tccattgtaa cataagttga caaaaaagaa aaagggaagc agccaaacgg 2741701 ctatttcccc tttttttata gtgatgcttt caaaattgac agcacatctt ctttgttgag 2741761 tgatttaaat tggccgaatg taccgttagc cattgccttg tcagcgattg tgtcaagctg 2741821 ctcatcatta atatcataat cagcaagacg gttcggagcg ccaagacttg tccagaatgc 2741881 ggacagctta tcgatacctt caagggcaat ttcttcatcc gttttacctg cttcttcaac 2741941 atcaaacacg cgaactgcaa gctgtttcat gcgggcaggg ttttcagaca atgtgtgtct 2742001 catccaattc gggaacagaa tcgccagtcc gccggcatgc ggaatatcat aaacggctga 2742061 tactgcatgt tcaatattat gagtagccca atcccctctt gcccccatag aaagcatgcc 2742121 gtttaatgcg attgttcctg tgtacaggat cgtctcacgc aattcgtaat tttcgagatc 2742181 attgatcagc ttaggcgctg tttcaatgac tgtacgcaaa agtgattcac acatgcggtc 2742241 ctgatacggc gtgtttgata catgatggaa gtattgttcg aatacgtggc tcatcatgtc 2742301 aaccatcccg tagatcgtgt ggtttttagg tacggtgaat gtattcaccg gatcaagaat 2742361 cgagaattta gggaatacga gcgggctgcc ccagccgtat ttttcttttg tttcccagtt 2742421 tgtaataaca gatcctgagt tcatttctga accagttgca gcgagagtca ataccgttcc 2742481 gaatggcaaa gcatcttttg gctgatgctt tttcgtaacg atatcccacg catcaccatc 2742541 atacttcgct cctgcggcaa tcgcttttgt acagtcgatt acgcttccgc ctccgacagc 2742601 cagcaagaaa tcaatgtttt gttctttaca gatggcaaca cctttattaa cagtcgacac 2742661 acgaggattc ggttccacac ctgctaattc atgcacggtc gctccggctt tattcagctg 2742721 ttcaatcact tgatcataca ggccgctgcg tttaatgctg ccgcctccgt acacaagcaa 2742781 tacgtttttt ccgtaaggtt tgagttcctc cggaagtctt tccacttcgc cgcgcccgaa 2742841 aattaatttg gtcggattcc agtatgtaaa gttttgcatg acatctcctc cttagatttt 2742901 ttattatgca gaatgtcctc accacatgta aagcaatcag ctctcaccga tcagcatacc 2742961 agatggtttt attttgcaag gtgctgggaa agaagctgat ataagcgagg gcaggccagc 2743021 ttccctcata tggagaatgc atgtatagat tctccaatat gtcacaatct ataactgttt 2743081 taataattca tggaggaggt tgcaaaacat gagtaccatt caaagaattt gtcttgtatt 2743141 aaccatcatt ggcgccatta actggggact gatcggattt ttccaatttg acttagtagc 2743201 ggctatcttc ggcggccaag ggtcagctct ttcccgaatc atttacggac ttgtcggaat 2743261 cgccggctta atcaacctcg gtctgctatt taagccaaac gaggaaagat cacgtgaaga 2743321 agcagcaaat cctgaaatgc gataggatat caatcacgct gaaataggat tttgcatgaa 2743381 atcaaaagca ccgaacattc ctgtccggtg cttttttcat gcttattttt tgataaggtc 2743441 tttgcggttg gacatttcga tccactcttc aagcttatct tttaatgtgt tgaaaccttg 2743501 tggtgtagaa gcttcttcgc ttacttgagc agctttaggt tttcttggtt tgctttcttt 2743561 tttctcaggc gcagcttgtg tcgcacgaat tgaaaggctg attttgcctt tttcttcatc 2743621 aacagcaagt acttttactt gtacttcgtc gccaactgaa aggtgctcgt tgatatcttt 2743681 tacgaaaccg tgagtcactt cagaaatgtg tactaaacct tgagtttctt catctaatgc 2743741 aacaaacgca ccatacgctt gtaatcctgt aactttacca gtgtaaacac tgcccacttc 2743801 aaattttgct gccattcata acaactccta agttaaatta aatatctgtt tatacgcaat 2743861 ttaaaattat atcacacatg tcttatttcc gcaaagaaaa cttttttata aaaaatcagg 2743921 tttatgcaca gcaaaaaggg ggtaaactga aaataccaaa ggctttctag tattcccccc 2743981 ttttattgga tgcgaacaaa aggttcgtat ctttttttat gttgttttgt gcaggaagcg 2744041 tttcattctg actaacgctt cttgaagctg ttcaatcgag gttgcgtatg aacaacggat 2744101 atatccctca ccgctcggac caaacacact tccaggaaca actgccactt tttcctgcgt 2744161 cagtagctcc tcggcaaact gttctgaact cattcccatg cttttgatag atggaaaagc 2744221 atagaaagcg ccgcccggat gatgacagct gagaccgatt tcattgagcg attctacaaa 2744281 cagattccgt cttcttcgat agcttttttt cattttttct acgtcttcca tgccgttctt 2744341 caggccttca agggcggcaa actgcgccat tgcgggcgcg cacatcatcg catactgatg 2744401 aattttaagc atggcatccc gaagcaagga tggtgccgcg gcaaaaccga gcctccagcc 2744461 cgtcattgca aatgcttttg aaaagcctga gatgactacc gtccgttcct tcattcccgg 2744521 taatgccgct atacttgtaa attcctcatc atatgtcagc tccgcgtaga tctcgtcggc 2744581 taagacgatg acatcatgtt ttttggcaaa ctcagcaatc tcattcagct cttccttcga 2744641 ataaaccgaa cctgtcggat tcgatggtga gcagatgaga atggcctttg ttttttcagt 2744701 gactgccgct tcaaaatcag cagccgttgc tttaaatcct ttgtctgccg ttgtatgaac 2744761 gtgaaccggg ataccgcctg ccaaagaaac aagcgcatcg tacgcaacaa aacacggctc 2744821 aggaatgatg acttcctcac ctggattcac aatggcgcgg atcgcaatat ccaaagcctg 2744881 acttgccccc actgtcacaa tcagctcatt atctggcgag tagctaaggt caaacctgtt 2744941 gctcaaataa cggctgattt cctcccgcaa tgagtataaa cccgcattgg ccgtgtatga 2745001 cgtatatcct tgttcaagag agagaatgct tgcttcgcgg acattccatg cggtaacaaa 2745061 atcaggctcg ccgacgccta aagaaatgac gccttccatc gttgccgcca aatcaaagaa 2745121 tttgcggatg ccggatggtt ttatttgttg tacatagtct gataaatacg aagtcattta 2745181 cggtgacacc acgattcttt tgtcgtcgtc tcctgtttca aacactttgc cgtcatgctt 2745241 gtattttttc aggataaaat gggttgtcgt agatacaact gaatcaagcg ttgagagttt 2745301 atccgaaaca aaacgcgcta cgtcagacat cgaattgccg cgaatcacga cagacaaatc 2745361 gtatacgcct gacatcaggt aaactgattc aacctcttgg aatcggtaaa tccgttccgc 2745421 cacttcatca aaaccgacgc cccgcttcgg cgttactttg acgtcaatca tggccgtaac 2745481 gccctcatgt ccgtcgactt ttcgccagtc aatcatagcg gaataatcga taataacctt 2745541 ttctttctcc agtttgtcaa taattgtttt cacttcattt acagggatgc ccgccatctt 2745601 tgcgattgtt tctaaatcgg cgcggctgtt ttcgtctaaa atttctaata tttctgtttc 2745661 tttttctgtc aatttcattt gattcacacc tttgcaatgt caagaaatct catgacatta 2745721 tatcacgttt tttgacgaat gctaagaaaa aacgaggaga aacttccgct agaattgaca 2745781 atttcagggc ataatacaac catcaaaaaa agggagtgac acagaatgga ggcggtttca 2745841 ccaataaggc ggtttacggt cgatggagtc aatgtatact acgaacatta tcaaaatccc 2745901 ggcaggcaaa cgctggtctg cgtacacggt tttttatcat ctgcattcag cttcagaaaa 2745961 gtaattcctc tccttcggga caagtacgac atcatcgcgc ttgatttgcc tcctttcggc 2746021 caatctgaaa aatcaagaac gtttatctat acctatcaaa accttgctaa gcttgtcatt 2746081 gggattttgg agcacttgca agtgaaacag gctgtgcttg tcgggcattc tatgggcggg 2746141 cagatatcgc tgtctgctgc tctccaaaaa cctgagcttt tttcaaaggt tgtgctgctt 2746201 tgcagttcag ggtatttaaa acgttcacac ccgacgatta ttttcgggac ccatatcccg 2746261 tattttcatc tttacatcaa acgctggctc tcgaaagaag gcgtgatgaa aaatttatta 2746321 aatgtggtgc atgacaaatc gctgattgat gaggagatga ttgacggcta tggcagaccg 2746381 tttcaggacg agcagatttt caaagccatg acaaggttta tccgccacag agaaggagat 2746441 ttagaacccg agcaattgaa gaaaatgaac aagcctgctc tattgatttg gggcgaggag 2746501 gatcgaattg tcccaatgga gatcggtaaa cggctgcacg cagatttgcc taattccgtg 2746561 ctgtactcac ttggccagac cggacatctg gtgcctgaag aacggcctga acttatttct 2746621 gaacacattg ctgattttat caaataacaa aaaaaccggt gctgaaccgg tttttttaag 2746681 gcgtgcagga gctgctgttt ttaatgaata aaagctggcc agccacttcc cggcagctgg 2746741 cgatcggcag cgtttgttca aaagaagttt caaatatttg ctgaatgctt ttcgccagca 2746801 agtcgggatc gttttcatca tagactgcct gcacgacatc aacagcctcc gtttcgtaaa 2746861 actcttctcc atatttaaac gggtcccatt tggcaatgat cttaatcatt tccctgaccg 2746921 catgactttc ttccatattc atcaccgctt ataataaaat ttgcagttct atcttatcat 2746981 agtgaagctt agaagaataa acatacatga gggggtaaca gaatgaactt tgataaacga 2747041 gaagaacgcc ttggcaccca atcggtcaaa tgggataaaa caggcgaatt atttggcgtg 2747101 acagacgccc tcccgatgtg ggtggcagat atggattttc gcgccccgga agcgataact 2747161 gaagcgttaa aagagcgtct tgaccacggt atttttggtt atacaactcc agatcaaaaa 2747221 acgaaggatg ctgtgtgcgg atggatgcaa aacaggcacg gctggaaggt aaatccggaa 2747281 agcatcacat tcagccccgg cgttgtaaca gctttgagca tggcggtaca agcttttacg 2747341 gagccgggcg atcaagtagt tgttcagcct ccagtttata cgccttttta ccatatggtg 2747401 gagaaaaacg gccggcacat tttacataat ccgctgctag aaaaagacgg cgcatatgca 2747461 atcgattttg aagatttgga gacaaagctt agtgacccaa gcgttacatt gtttatttta 2747521 tgcaatcctc ataacccttc tgggcgttca tggagccggg aagatttact gaagctaggc 2747581 gaattgtgcc ttgagcatgg cgtcacagtt gtatcggatg aaatccattc cgatttaatg 2747641 ctgtacggac ataaacacac gccgttcgct tcgctctctg acgatttcgc tgatatttcc 2747701 gtgacatgtg ctgctccaag caaaacattt aatatcgccg gattgcaggc ttcagcgatc 2747761 attattccgg atcgcctgaa gcgcgccaag ttttccgcaa gccttcagcg aaatggttta 2747821 ggcggactga acgcgtttgc cgtcactgca atcgaagccg cgtattcaaa aggcggaccg 2747881 tggcttgatg aattgatcac ttacattgag aaaaacatga acgaagcgga agcctttttg 2747941 agcaccgagc tgccaaaggt caaaatgatg aagccggatg catcatactt gatttggctc 2748001 gacttcagcg cttacggctt gtccgatgca gagcttcagc aaagaatgct aaaaaaagga 2748061 aaagttattt tagagcccgg gacgaaatac gggcctggcg gagaaggatt tatgcgcctg 2748121 aacgccggat gctctcttgc aaccctgcag gacggcctgc gccgcatcaa agccgcatta 2748181 tcgtaaatat agctgtaaac gcctttacgt cttcatttgt aaaggcgttc ttaataaagg 2748241 aattttatat tttacttcta atatttagtg ttataataga ttcatatttt atacgaaagg 2748301 atttcacacg aatggaaatt ctaaaagact atcttctgca catctgcttt attttgtttc 2748361 ctattcttct ttaccaagtg ttttggcttg gaaaacctgc gattcttgtg ccaaaaataa 2748421 acagcggttt ggtcacgctc ttcgcctgcg gcgcctccgt tttatgcatt attttcccga 2748481 ttcatgaaat ggactacata caatacggcc ttcagatgat tcccgttatc atttgtttat 2748541 tttacattag taccgcttcc ggacttacag tcgccgcatc tgtcctatgt tttgaactgc 2748601 ttttttacga accttccgca atgtttgttt tcactttgct gccttttctt atcattatcc 2748661 caatcttatt tcagaaaaaa tggccattca tgtccaaagc gaaaaaactg ctgctgtctt 2748721 tattgatcag ctgcgtggag attttcctat ttttcgcctc aagctggatt ctttccgcct 2748781 tgaatatttt aaattttcaa aaatcaggaa ttttcgttta cgaggcggca gtctcagggc 2748841 ttttccgctc cagtgttctt ctattaagca tctatattat cgaaagcatc gccgaaaata 2748901 tcgccctgcg ttcacagctt atccattctg aaaaaatgac gattgtgagt gaactggcag 2748961 cgagcgtcgc ccatgaggtc aggaatccgc tgacagttgt ccgcgggttt gtccagctgc 2749021 tttttaatga cgaaacccta caaaacaagt cgagtgcgga ttacaaaaag cttgtactgt 2749081 cagagcttga ccgggcgcaa ggcattatca caaactatct cgatatggcc aaacagcaat 2749141 tatacgaaaa agaggttttt gacctatctg cccttatcaa agagacaagc tcccttatgg 2749201 tgtcgtacgc caattacaag tcagtaaccg tcgaggctga aacagaaccg gaccttttga 2749261 tatacggaga cgcaacaaag ctgaagcagg ctgtcatcaa cctgatgaaa aacagtattg 2749321 aagcggttcc tcacgggaag gggatgatcc acatatcagc caaaagaaac ggccatacga 2749381 tcatgattaa catcacagac aatggggtcg ggatgacaga ccatcaaatg caaaaactcg 2749441 gcgaacctta ttattcctta aaaacgaacg gaacgggact cggcctcacc gtaacctttt 2749501 ccattattga acatcatcac gggaccattt catttaacag cagcttccaa aaaggcacta 2749561 cggtgaccat taagcttccc gctgatcttc ctcactagca aatcgattgg aactttaata 2749621 gaataaatgc gaggtgatga cagatgagca cgtttgagac aggctctatc gttaaaggat 2749681 tttacaaaac aggtgtatac ataggagaaa tcacggcttg caggccgcag cattatttag 2749741 tgaaagtgaa agcggttctt acccatcccg ctcagggaga ccttcatcat ccaaaacagg 2749801 cggatgtgcc attttttcat gagagaaaag cgctcgcata tggtgaacag accaatatcc 2749861 cccaccatat ggtgaagcct tatgacggtg aagtgccgga ttataccgaa tctctgcggg 2749921 aggcgacagc acagatgaga gccaaattga atgaggatgg ttcggagtgg gcaaagcgct 2749981 cccttcataa tctggacatt ttagaaaaag aatattttaa ccggccataa cccagtctga 2750041 caaaagattg ggttttttac gtcgcgcgct tcaacagttc ggttaaatcg attctctcgc 2750101 cgattgtggg cggttttggc ttttcgagat actgcttatc ctgctcaaca agcttaaaaa 2750161 gtttatatgc tgtgagagca tcatcaagcg ctttatgatg ggtgccggtt ccggaatctc 2750221 catactcttc ggcagctttc cataaacccg tcaatgtccg gtctccaaaa aagtttttgt 2750281 attcaagcga taaatctctc atttctccct taaacgggaa agggatatgg ttaaacatac 2750341 agttttgctt cagcactttc atatccatgt ttccccacgt aataattgtg ctgtttttct 2750401 caggatccag ctcgtttagt ttacggatga aatcctcgaa tctcattcct tcgtctacct 2750461 gtttttgggt tatttttaaa aatgatttgc agcgtttcgt aagcttcggg aactttttcg 2750521 gtctaacata gctagaaaac gtctcaacca cttcatcatc aatcgacttt acaattccgg 2750581 cttcaatgat ttccgggaag aagttttgag gactgtactt tccatcaggc attgtaaatt 2750641 cgaaatcaat aatgagtaag ctgtttgtcg tcacctttta cacctgcctt tcctccgatc 2750701 agaaaatgct atctttatag tatatcaatt ccccttctcg acatttcttc attttctaaa 2750761 aataatgaat tttcccagcc gcttcgtttc ttttaaattg tgaatcgttt ctttataatt 2750821 agtaaggaac ccgaaataat aagaaggtga tgttatttct atccgtaaga aaaactttgt 2750881 cattgtgtgg ctggcgaact tttttgtctc cgctagcaca acgatgatcg ttccttttct 2750941 ctccttatac attgagacgc tcagctcttt ttcaaacggc tttgtgcaaa ggtggagcgg 2751001 ctatgtgttc ggcattacat ttctcatggc gtttttggta tccccgtttt ggggacggtt 2751061 cggagacaaa cgcggataca agaaaatcct tatggcaacc ggaacaggca ttgccctcag 2751121 cattttcttc atgggctttg ttacatcggt gtaccaattg ttttttctgc gtatggcaat 2751181 gggtcttgta accggattca tcccgacatc tcttgcgatg atttcggcac agactccgaa 2751241 gagctcagct ggcaaaacac tcggcacgct gcaaatgggg caagtgtccg gaagcttgtt 2751301 cggcccgctt ttgggaggca tgcttgctga tcgtttcggc tttacgtata ccttttttat 2751361 cacatccttt gtgattttct cgtctgttct tctcgtgtta tttggtgtca aagaaaagca 2751421 tcttgcagag aaaacagcca aacgtacgtc ttactcgaga aaagaagtgc tctcctatat 2751481 ttttcaccat ccggcgctgt gggtcatgat gctgttaacc atgctgattc aaacaggcaa 2751541 tttcagtatc cagcccctgc tcgctttata tgtaaatgag ctgcacggac ctgtcaatct 2751601 tgcctttttc tccggcatgg cattttcagc aacggggctc ggaagtttgc tgctggctag 2751661 aaaatggggt gatctgggcg accgctacgg ccaccgccgc attttaatcg gacttttgct 2751721 cgccgcctct ttctttttta ttccgcaggc gctcgcgtcc tcactcagcg tgctccttgt 2751781 tttcagattt ttattcggaa tggcgatggg cggtttgctg ccatgcatta cggcagcgat 2751841 ccgcgttcag gctcccggca gcattcaagg tgaagttctc ggctacaatg tcagctttcg 2751901 ctttttagga aacgtgctcg ggcctctgct cggcggaatc atatcgagcc attttaccat 2751961 ttcggccacc ttttacgtca cggcgtttct ctttttcgcc ggcgcctgca tgctttggat 2752021 catgcagaaa cttcggaaag attcttatgc caaagcaagc tgattccgag aaaaaactaa 2752081 ggaatcttct aaatttaacc ttctcgtaat ctcaaaagaa tggtacgata tggctagaat 2752141 ttaggagaaa agagagtgac catgttacga aaaataatcg gatggatttt gctcctttgc 2752201 ataatcccat tgtttgcatt tacagttatc gcttccggaa aagaagtaaa acaaatgaag 2752261 tccctggatc aggtgcttga taaaaatatt gatctgaaag atatcagcct tgttcagaac 2752321 agctacatgt atgacaggga cggctccctt gtctcggaaa tcgtcagcga ccacgaaaac 2752381 cgtgtgctcg ttccatttaa caagattccc gaggaagtca aacagatttt cttaacatct 2752441 gaggaccgcc atttttacga gcataaaggc tttgacttta tgggaatggt gcgggctact 2752501 gcttctaacg taaaagacaa gaaaattgac cagggtgcca gcaccatcac acagcagctt 2752561 tcaagaaact tgtatttgag ccacgaacgc tccttcagcc gcaagctgac agagctcgcg 2752621 tattcctatc agctggagaa aaaatatacg aaaaatgaaa ttcttgaagc ttacttaaat 2752681 accatttatt tcaacaacgg tgtttacggc gtcggttcag cagctcaatt ctatttcagc 2752741 aaaccgctga aatctctcac agtgggagaa atggctttta tctgtgctat acctaataac 2752801 cctacattat atgatcctct caagcatttt gactacacga aaagccgtca agaacgttta 2752861 cttaaagggc taaaagatgc cggggtcatt acggacaaag agctgaaaaa agccgtaaaa 2752921 caaaaaatca aactggatgt tgaaaaaaga gaagacaaat atcctgacta cgtttcctac 2752981 gtcaatgatg aattcactca gctggtgtct gaatcagaag gctttgataa acgccttcaa 2753041 aaagcatcag gaaaacaaaa agaaaagatc gagaacgagc tgtccgcaag agtcagcacg 2753101 ctgatgaaag acggagtgaa aatttatact gcacttgatc cgtacatgca aaatcaagtt 2753161 gtggcacaaa tgaattccaa gctcccgtat gcggacgtac agggcggagc ggctgtgatt 2753221 aatcaccaga cgcatcaaat cattgctcta tccggcggga aaaactatca aaaatatgac 2753281 tttaaccgcg cctaccaggc gtacaggcag ccgggttcat ccattaagcc gcttcttgat 2753341 tacggccctt atattgaaca gaccggcgcg acaacaagca gcaccattga tgccagcaag 2753401 ttttgcagca aagactactg tccgcaaaac tacaataacc gcacttacgg cacagtgacg 2753461 cttgatacgg cgtttaaaaa ttcatataat accccggcta ttagaatgct cgaccgcgtc 2753521 ggcatccaaa aggcattcag ttatattgag ccgtatcatt ttgccaaact tgtcgacagt 2753581 gactatcttc ttccggcggc gcttggcgga tttacaaacg gcatgacgcc tcttgagatg 2753641 acaaaggctt atacgacatt cggaaacagc ggaagctata cgccgagcca tgcgattaca 2753701 aaggtgacag accttaaagg aaaaacactt tataaatgga atgataaagc gactcaaata 2753761 ttcagcgtcc gcacgaacat gcagctgaaa aaactgatgt cttccgttgt gaaaagcgga 2753821 acagggaaaa aagcatattt caatgcgcct tacatcggcg gtaaaaccgg aacatcaaat 2753881 gattatcacg atatgtggtt tgtcggcctg actgatacgt atacaatggg tgtctgggtc 2753941 ggaaaggata caccgaccag cgttgaatat cttcacagca tcagccctca gctttccatc 2754001 tggaaaggaa cgctgcaagc ggcttattaa aggatcggag gggatatgga gtgacttcag 2754061 aacaaattcc aaatcgcgtt ttgctgtttg acggtgtctg caatttatgc aatggcgccg 2754121 tgcagtttat cattaaacgt gatccggacg gattgatttc tttcacatcg ctgcagtcgg 2754181 aaacaggaca gagcctgctg aaaaaaagcg ggcttccgac tgatcggttt gacagctttg 2754241 tctttattga agacggccaa gtgtacacaa agtcaactgc agccattaag gttttcaggc 2754301 atctgcgagg cccatggcgg ctcttcgtcc tttttttcgc agtgccgaag cctgtcagag 2754361 atatggtcta ttctttcatt gccaaaaacc gctataagtg gtttggcaaa aaaaatgaat 2754421 gtatgctccc ctccccttcc attaaaaaaa gatttttacc gtaaataaaa aatggctagg 2754481 aagctagcca tcacagattg ttgacaaaat cctaaaacgg cttcgtttta ggattttgtc 2754541 atctattcag cgtgattgaa aacttttgaa gttgtgaaac ggcggaaacc tgagaatcta 2754601 gccgccgttt cattgcgtac agagcacgaa gcgcaaatct gaccaccaaa cgctgaaatg 2754661 gctagcttac acaggtaagc tagccattat gctattataa agcttgataa atatgaacag 2754721 aataccgata acaaaggtaa accaaaacag cagttccaat agaatgaatc caactaatga 2754781 catgagagaa agcgtcgaat aaatccggta tacggtaaac acaaagtaag cgagcgtgac 2754841 gaccgcaaac cagatcacaa tccaaatgac attttgcaag agcacaaagg ataaaatccc 2754901 gccgcccaaa taaatcatgg aacccattct gagttttttc aggttgttcc cttccggatc 2754961 attagcaaaa aacagcaatg acagctcggt cacggtattt gcaattaatt tcagagcgga 2755021 cagaaccata aaatataaaa gtgcaaaggc agcaaataac gcaagcctga ttcctttctc 2755081 tgaaaaataa tcgagcattc catcatacat tccaaatgaa gacagcatct tcaacgcata 2755141 aagtgaagtt gagatggata aggacgaact aaaaagcagg atcgcaatca gcggaaaata 2755201 tcctgtcaaa taagtatttt tcatataaaa aagtcccttt ctataatcta cctcatttat 2755261 tatggaggac ttaaaacaca ttgacaagat aaattattcc attttttctc ctttttacga 2755321 attacgggcc caaatcttca caaagcagca ttttgagagt aaagtagtac gcaggaatca 2755381 taaaacgtaa ggaagtttta tatgaaaaaa acattaaaac tgcaaaccag actcaccata 2755441 tttgtttgta tcgttgtatt aatcgcattg ctcattacgt tttttacagt cggtgcccaa 2755501 accaccaaac gaattagaga tcaggaaaag gccactgcgc tgcagactgc tgaaatggta 2755561 gctgaagcgc cgatgacagc cgctgcttta gaaagcggaa aaaaacaaaa ggaactgcag 2755621 agctacacaa agcgggttca gaaaattacc ggcacggaat ttgttgtcgt catggatatg 2755681 aacggtatcc gcaaaactca tcctgacccg agcaaaatcg gaaaaaaatt cagaggcggt 2755741 gatgagtccg aggtattaaa agggcatgtc catatcagca cagcctctgg cacgctcggg 2755801 aaatcgcaga gagcgttcgt ccctgtctac gcggagaatg gaaaacaggt cggtgcagtc 2755861 gcggtcggca tcaccgtaaa tgaaattgat gaagtgatca gccatagctt acggccgctt 2755921 tactttatta tttgcgtcag catcttcgtc ggtgtgatcg gagccgttat cgtcgcccgt 2755981 acagtgaaaa atatcatgta cggacttgaa ccttatgaaa ttgcgactct gcttgaagaa 2756041 cggagcgcga tgctggaatc gacgaaggaa ggaatactcg ctgtcgatga acatggcaaa 2756101 attaaacttg ccaacgcgga agcaaaacgc ctattcgtca aaatgggcat caacacaaat 2756161 cccattgatc aggatgtaga tgacatcttg ccgaaaagcc gcttgaaaaa ggtcattgag 2756221 acaaaaaaac ctcttcaaga cagagacgtc cgcattaacg ggctggagct tgtgtttaat 2756281 gaagttccta tccagctgaa aggacaaact gtcggagcga ttgcaacatt ccgcgacaag 2756341 accgaggtaa aacatttagc tgaacagctt tccggtgtta aaatgtatgc aaacgcactg 2756401 agagcgcagt ctcatgaatt tatgaacaaa ctgcatgtga tattaggtct cgtccagctg 2756461 aaagagtatg atgatcttgg agattatatt aaagatatag ccatacagca aaaatcagaa 2756521 acaagtgaaa ttataaatga tgtcaaaagc tccgtactgg ccggttttct gcttggaaag 2756581 caaagcttta tacgtgagca gggcgcaaat cttgatattg aatgcaacgg tgtcatcccg 2756641 aacgcggcag acccttctgt catccatgaa cttattacaa tcatcggaaa tctcatcaac 2756701 aatggcttag atgccgttgc cgatatgccg aaaaaacaaa tcaccatgtc catgcgcttc 2756761 cataacagca tacttgatat tgaaattacc gatactggag caggcatgtc tgaagaagac 2756821 caagccaaag tatttgaaca aggctattca acaaagggca aaaaccgggg attcggcctt 2756881 tatttcacac agcaaagcat cgaaaattta aaaggccaaa tgatcctcac aagcgaaaag 2756941 aatgaaggaa cgacattcag tattcgcatc ccgtacgaac cgaaggagga aaatcatgat 2757001 taatgtacta atagttgaag atgaccccat ggtgggtgaa ttaaataaac gatacttaag 2757061 ccaaatagat ggctttcagc tgaaaggcat cgcttcttcc tttcaaagcg ctctgcatat 2757121 tttaggggag caccatattg acctcatttt gcttgatatt tatatgccgg gaaaaaacgg 2757181 gctggaactg ctgacggaat tgagagccca aaatgaagcg gttgacgtga ttgtcatctc 2757241 agcggccagc gagcttgacg tgatcaagaa aacacttcgg tacggagctg ttgattattt 2757301 aatcaaaccg tttgaatttg aacgattcca aacggctctg tctgattaca gacgaaaaca 2757361 aaaggtgtat tcaacccatc gcaacatgag ccaaaaagaa ctggacgccg agctttttca 2757421 aaagaaagaa gcaacagaaa aagtgcagct tcctaaaggc ctgacaaaaa gcacgctgaa 2757481 gctgatctgg tccagtatcc agtcatttga aaatgaatct tttacgacag aagacttggc 2757541 aaagcacaca gaaatctctc aagtatccat acgaaaatac ttaaagtttc ttgaagatat 2757601 acaggttctg aatgtagaaa tggcgtacgg aacgatcgga agacctgtgt ttcagtacaa 2757661 cgtcaacaac agtaacatta acggaataaa gcaatatcta taagaaaacg cactgcttgc 2757721 tttgagcagt gcgtttttct gtcatatctc ttgccaagat gcttgattct attgttgata 2757781 agttatacaa gaataacaaa gggctttcac atttttaagc aaataattct aaaaatagat 2757841 aatttttaaa aaattatgcg aaattctatt tatttcttat tagttaaatg ataaattatg 2757901 attggttagt tgatcccgaa aaactaagtc ataagtctta cttcagaaaa cgatgtcacg 2757961 gttttccgcc cggaacgcct tccgcatcct tctcttcccc gcctttcgaa ggaaatactc 2758021 acaccacgct tattcaggga agaatagaac tgtctcagcg cattccattt gttattatca 2758081 gaaaatttta tcgattctaa gaaattgttc aggacagccc atcacatgac tggccggatc 2758141 agctttgaac caaatttttc tggggggtta tatcttgaat aaacgaaaaa tcggattggc 2758201 gatgtcactt gtgatcgcag caggcaccat attaggagca tgcggaaaca gcgaaaaaag 2758261 cagcggctca ggcgaaggca aaaacaaatt cagtgtggcg atggttactg acgtaggcgg 2758321 agtggatgac aaatccttca accaatcagc ctgggaaggc atccaagcct ttgggaaaga 2758381 gaatgggctg aaaaaaggca aaaacggtta cgactatctt caatccaaat ctgatgcaga 2758441 ctatacaacg aacttaaata aattggcgcg tgagaatttt gacttaattt acggcgtcgg 2758501 ctacttaatg gaggattcaa tcagcgaaat tgctgaccag cgtaaaaata caaactttgc 2758561 gattatagat gctgttgtcg ataaagacaa cgtcgcaagt attacgttta aagagcagga 2758621 aggctcattt ctcgtcggag tggccgcagc cctatcaagc aaatcaggaa aaatcggctt 2758681 tgtaggcggc atggaatcag agttgatcaa aaaattcgag gtcggcttcc gtgccggcgt 2758741 gcaagcagtt aaccctaaag ccgttgtaga agtgaaatac gcagggggtt tcgataaagc 2758801 cgatgtcggt aaagcaaccg ccgaaagcat gtataaatca ggcgtagatg ttatttatca 2758861 ctctgcgggc gccactggca caggcgtctt tactgaagcg aaaaacctga aaaaagaaga 2758921 tccaaaacgc gatgtctggg tcatcggtgt cgataaagac caatacgcag aaggccaggt 2758981 agaaggaaca gatgataacg tcaccctcac ttccatggtg aaaaaagtag atacagtcgt 2759041 tgaagatgta acgaaaaaag cgagtgacgg aaagttcccg ggcggcgaaa cacttaccta 2759101 cgggcttgat caagacggag tcggcatttc tccatctaaa caaaatctat cggatgatgt 2759161 gatcaaagcg gtcgataaat ggaagaaaaa aatcatcgac ggattggaaa tcccggcaac 2759221 tgagaaagag ctgaaaacct tcaaagctga ataagaatcg cagggataag gaggtcgagc 2759281 ccttatccct tgtttttctt ttattttgaa ataaaggagc ggtcaatcaa tggaatatgt 2759341 cattgaaatg ctcaatatcc gcaaggcgtt tccaggtatc gtcgccaatg acaatatcaa 2759401 tcttcaagtc aaaaaaggcg aaatacacgc gttgctcggt gaaaacggag cggggaaatc 2759461 aacattgatg aatgtccttt tcgggctgta tcagccggag cggggtgaaa ttcgggtgcg 2759521 cggcgagaag gtgcacatca acagcccgaa caaagcgaat gaccttggaa ttggaatggt 2759581 gcaccagcac tttatgcttg ttgacacctt tacagttgct gaaaatatta ttctcgggaa 2759641 ggagccaaag aagtttggca gaattgaccg gaagcgtgct ggccaagagg tgcaggacat 2759701 ttccgatcga tacggcctgc agatccatcc tgaagcaaaa gcagctgaca tatcagtcgg 2759761 tatgcagcag cgcgcagaaa tattaaaaac cctctaccgc ggtgccgaca ttctgatttt 2759821 tgatgaaccg acggctgttt tgacgcctca tgaaattaag gaactgatgc aaattatgaa 2759881 gaacctggtc aaagaaggga agtccatcat cttaatcacc cataagctga aagagattat 2759941 ggagatttgt gaccgcgtta cggttatccg taaaggaaaa ggcatcaaaa cccttgatgt 2760001 ccgtgataca aaccaagacg aactcgccag tctaatggtc ggccgtgagg tatcgttcaa 2760061 aactgaaaag agagctgctc agccgggagc ggaagtgctt gcgattgacg gcataactgt 2760121 aaaggatacc cgcggaatag agacagtcag agatttgtct ctttctgtca aagcgggaga 2760181 aatagtcggc atagcaggcg tcgacggaaa cgggcaatct gagctgatcg aagcggtgac 2760241 aggactccgc aaaacagatt caggaacaat caccttaaac ggaaaacaga tccaaaacct 2760301 gacgccaaga aaaatcactg aatccgggat cgggcatatt cctcaggatc gccataaaca 2760361 cggtctcgtc cttgattttc caatcggaga gaatatcctg ctgcaaagct attacaaaaa 2760421 gccgtattca gcattgggcg ttttacataa aggcgaaatg tacaaaaaag cacgcagcct 2760481 gatcactgag tacgatgtca gaacgccgga tgaatataca cacgctcggg cattgtcagg 2760541 cggaaaccag caaaaagcga ttatcgggcg ggaaatagac cgaaatcctg atttattaat 2760601 tgccgcccag ccgactcgcg gccttgatgt cggagcgatt gaatttgtcc ataaaaagct 2760661 cattgagcag cgtgatgccg ggaaagccgt tcttctcctc tcgtttgagc ttgaagaaat 2760721 tatgaatctc agtgacagaa tcgccgttat ttttgaagga cgcattatcg ccagcgttaa 2760781 tccgcaggaa accactgaac aggagcttgg tctcttgatg gcaggaagca cgcaaaagga 2760841 agcggggaaa gcaaatggtt aaacgactct ctcatttact cgtgccgctc atcgcaatca 2760901 tacttggtct tgcggccggc gcgttgatta tgcttgtgag cggctacagt gtggctagcg 2760961 gatattcggc tttgtggaat gggatattcg gagaaatcta ttatgtcgga gaaacaatcc 2761021 ggcaaattac gccttatatt ttatccggat tggctgtcgc ctttgcattc cgaaccggac 2761081 tctttaatat cggcgtcgag ggacagctgc tcgtcggctg gacagcagcg gtttgggtcg 2761141 gtacggcgtt tgacggaccg gcatatattc acttgccgct cgcattgatt acagcggcag 2761201 ctgcaggagg attatggggg tttattcccg gcattttgaa agcgcgattt tacgttcatg 2761261 aagtcattgt caccattatg atgaattata tcgcgctgca catgaccaat tacatcattt 2761321 caaacgtctt gacagatcat caggacaaga cggggaaaat tcacgaatcc gcctccctcc 2761381 gctctccttt tcttgaacag atcaccgatt actcacggct gcatttggga atcatcgttg 2761441 cccttctcgc agcagttatc atgtggttta tcatcaacaa atctacaaaa ggatttgagc 2761501 tccgggcggt cgggtttaac cagcacgctt cccagtatgc cggcatgagc gtgcggaaga 2761561 atatcatgac ctccatgctt atctccggcg cttttgcagg tcttgccgga gccatggagg 2761621 gcctagggac attcgaatac gcagcagtga aaggcgcatt taccggcgta ggctttgacg 2761681 gtatcgctgt cgctcttctc gggggaaaca cagccgtagg cgttgtactg gcagcatgcc 2761741 tgcttggcgg gctgaaaatc ggcgcattaa atatgccgat tgaatcaggc gttccatcag 2761801 aggtcgttga tattgtgatt gccattatta ttctatttgt ggcttcaagc tatgcgattc 2761861 gtttcgtcat gggcaaattg aagaaaaagg gggcgaacta agtggacatt gtgcagattt 2761921 tatctatcat tgtccctgcc acactcgtct atgcggcccc gcttatttta actgctctcg 2761981 gcggcgtgtt ttccgagaga tcaggtgtgg tgaatatcgg cctagaaggc ctcatgatta 2762041 tcggggcgtt caccagcgtg ttatttaatt tattttttgg tcaggaatta ggtgccgccg 2762101 caccttggct ttcgctcctt gccgccatgg cagcaggcgc cctgttttca ctgattcacg 2762161 cggcagcggc gatttcgttt cgcgccgacc agacagtcag cggtgtcgcc attaacatgc 2762221 tggcgcttgg ggcaacttta tttatcgtca aactgatcta cggcaaagcg cagacagaca 2762281 aaattccaga gcctttttat aagacgaaaa tccccggttt gggcgatatt cccgtcttgg 2762341 gaaagatctt cttttcggat gtctattata cgtctattct tgcaatagca cttgccttta 2762401 tttcctggtt tatcttgttc aaaacgccgt tcggccttcg tatccgttct gtcggcgagc 2762461 atccgatggc ggccgatacg atgggaatca acgtatataa aatgcgctac atcggcgtga 2762521 tgatcagcgg attgttcggc ggtctcggcg gcggcgtata tgcctccaca attgcgcttg 2762581 atttcacgca ctctaccatc tccgggcaag gttttatcgc cctggcagcg cttgtattcg 2762641 gaaaatggca tccgatcgga gcactggggg ccgccctgtt tttcggattc gcccaaagct 2762701 taagcatcat tggatcgctg ctccctcttt ttaaagacat accaaatgtg tatatgctga 2762761 tggctcctta tatcttaacg attctcgctt taaccggctt tatcgggcgg gcagatgcgc 2762821 caaaagccaa tggcgtgcct tatattaaag gaaaaagata aacattctcc cctgggaaga 2762881 cgattctcag ggattttttt ctaatccaaa agaccccctt aatttaattg tttattagtt 2762941 ttttaactta aaaaaatatg aagtgttaac gctttcttgt agactgtaac aaacaataca 2763001 tgggggtgta tgacatggga gcaattccaa aaacggggac aatttcacct gagcaaaaag 2763061 actcacagga gaaaaacctg tttcaaaaaa tttggtcttg ggaaatcggt gtgattcctt 2763121 tgccattata cacagtatta gctgttatta ttattcttgc agcatattac aatgagctgc 2763181 cggcaaatat gcttggcggg tttgccatca ttatgattct tggtgtgttt ctcggagaca 2763241 taggccaacg cataccgata ttgaaggata ttggcggccc tgctatttta tctttgtttg 2763301 ttccttcatt tttagtcttt tacaatgtac tgaattcaac atctttagac gctgtaacca 2763361 acttgatgaa aacgtctaac ttcctttatt tctatatcgc ttgccttgtt gtgggaagta 2763421 tcctcggtat gaacagaatt gttttaatac aggggtttat cagaatgttc gttccactgg 2763481 ttgcaggaac gatcgcggcc gttgcagccg gcatccttgt cggatttatt tttggctata 2763541 gtgcctatga ttcctttttc tttgttgttg tcccgattat tgccggggga ataggtgaag 2763601 ggattttgcc gctttcaatc gcctattcac aaatactggg ctcatccgcc gatgtatttg 2763661 tgtctcagct ggtgccagcc gcaattatag gaaacgtttt tgctatcata tgtgcagcct 2763721 taatgaaaaa gcttggcgac aagcgtccag atctaaatgg gaacggacgt ctcgtaaaat 2763781 ctaaaaaagc aaatgagatt ttcaatcaaa aagaagccga agcaaaaatt gattttaaac 2763841 taatgggagc aggagttctg ctcgcgtgta cattctttat ttttggcggg ttattggaga 2763901 aattcatctt catcccgggc gcgatcttaa tgattatttc agctgcggct gtcaagtatg 2763961 caaatattct tccgaaaaaa atggaagaag gcgcttacca gctttataag tttatttctt 2764021 caagctttac atggccgctg atggtcggtc tcggcatcct ctttattccg ttggatgacg 2764081 tagcgtctgt gatttctata ccgtttgtca tcatctgtat ttcagttgtt atcgcgatga 2764141 ttggttctgg atatttcgta ggcaagctga tgaacatgta tccggttgaa tccgcaatcg 2764201 ttacctgctg ccacagcggt ctcggcggaa cgggtgatgt tgccatttta tcggcatcag 2764261 gaagaatggg ccttatgccg tttgcccaaa tttcaacccg tctcggcggt gcaggcacag 2764321 ttatttgcgc gacagtgctg cttcgttttt tcacttcata aacagaaaga gttccgtttt 2764381 atgcggaact ctttttttat ttattcacaa tccgaatata ctctcgggga ccaaacggca 2764441 gatcctttga ttccgtctca ctcattctgg ctgacaggtg gtgctccagt aaatacagct 2764501 cccactcatc acaagccgcc acaccgctgc gcccgtcata ttgattcaac atgaatgccc 2764561 ctgcaaatac tgagcagaat aaacctgagc acatcacgac ttttgttttc acatgaccag 2764621 ctcctttcct tcagcttgat caggattgat tttaaatata caaataacct cttttttgtt 2764681 agacttattt tgaggtcaaa agaactcata aaaatccatt acagcagttc gaagcgtggc 2764741 agcttgcaga aaagtgcgat ataatttgga ctaggtcgtt tgaccgtata ttttatacat 2764801 agcgcatttt tcaattgaga acgagaaaag gaggtcttat ctttgcagct cttacatctt 2764861 gctattttat cgcctttttt atttgctttt atcattccct tcttggcaaa atacgcaaaa 2764921 agagtgcata cgggctggtt tgtgttgatc ctgcccgtct tgctgtttat atactttctc 2764981 ccaatgatca ggatgacgca atctggagaa acacttcgat cggtattaga gtggattccg 2765041 tcactcggca ttaactttac cgtttatata gacggcctcg ggttattatt cgctttactg 2765101 atcacaggca ttggctcttt ggtcactctt tacagcattt tttatttatc gaaagaaaaa 2765161 gaacagcttg ggccctttta tgtctactta ttgatgttca tgggcgccat gctcggcgtc 2765221 gttctagtag acaatgtcat ggttctctac atgttctggg agcttacaag cctttcatcc 2765281 tttttgctga tcggctattg gtataagcgg gaaaagtcgc gctatggcgc agccaaatca 2765341 cttttgatta cggtcagcgg cgggctgtgc atgctcggcg gatttattct cctttatttg 2765401 ataacggatt ccttcagtat tcgagagatg gttcaccagg ttcaattaat tgccggccac 2765461 gaattgttta tcccggctat gattctcatt ttattagggg cttttacgaa atcggcgcaa 2765521 tttccttttt acatctggct ccctgacgcg atggaagctc cgacgcctgt cagcgcttat 2765581 ctccattcag ctactatggt aaaagccggc atttatgtga ttgcgagatt cagtcctatt 2765641 ttcgcctttt cagctcagtg gttttggatc gtgtccctcg tcggcctctt tacgatggtt 2765701 tggggttcat tccatgccgt gaaacaaact gatttaaaat cgattttggc gttttcaacc 2765761 gtcagccagc tcggcatgat catctccatg ctcggagtca gtgctgcggc ccttcattac 2765821 ggacatacag aatattatac agttgccgct atggctgcca ttttccattt gatcaaccac 2765881 gcaaccttta aaggaagctt gtttatggca gtcgggatta tcgatcacga aacaggcaca 2765941 cgggatatcc ggaagctagg cggcctgatg gcgattatgc cgattacttt taccatttcc 2766001 ttaatcggga cattttcaat ggccggccta ccgccgttta acggattttt gagtaaagaa 2766061 atgtttttca caagcatgct tcgcgtgaca cattttgacc tgttcaacgt gcagacatgg 2766121 ggcgttctgt tccctctttt cgcctggatc ggaagtgtat ttacgtttat ctacagcatg 2766181 aaattgctgt ttaaaacatt cagaggaaat taccagcctg aacagcttga aaaacaggct 2766241 cacgaagcgc ctgtcggtat gctcgttcca ccggtcattc ttgtcgcttt ggctgtcagt 2766301 ctcttctttt tcccgaatat attgtcgtac agcctgatag agcctgcgat gaactcaatc 2766361 tatccgacac tgcttgacgg ccatgagaaa ttccacgttc acatttcaca gtggcatggg 2766421 gttacaacgg aattgctcat gactgcgggt attgttgtga tcggaacaat tggttatttg 2766481 tcgctgaata agtggaaagg aatctataaa ctgtttcctt cgaaactcac actcaaccgg 2766541 ttatacgata agcttttgac tatgatggag aaaggctctt accgggtcac aaaacaatat 2766601 atgaccgggt ttttaagaga ttatttgctg tatatcttcg ctggtttcat cattctgata 2766661 ggcggagctt ttgccattaa aggcggattt tcatttaaaa cggaaggcat ggctaaaatc 2766721 ggtgtatacg aaatcatttt gacgcttgtc atgatcagcg ccacagtggc gactgttttt 2766781 gctaggtcaa gactgacggc gatcattgca ctcggtgttg tcggttatac gcttgcattg 2766841 ttttttgtca ttttcagagc gccggacttg gcattgactc agctcgtcat tgaaacgatt 2766901 tctgtggcac tgtttctgct ttgcttctac catttgccga aactgaggct gaaaacaaaa 2766961 acgagaacgt tccggatgac gaattttatc atttctttag gcgtcggtgt tatcgttaca 2767021 ctgctcggca tcgcatcctc aagccagcgg acaaaagaca gcattgcgtc cttctttgtc 2767081 aaacacagcc acgatctcgg cggaggggat aatgtcgtca atgtcattct cgttgatttc 2767141 aggggatttg atacaatgtt tgaaattacg gtattaacga tagccgctct cggcatttac 2767201 agcatgatta aaacaaaagt aaaagaggag gggaaaagcg gtgaatgaac aaaaaacaaa 2767261 tgacttgatt cttcaaaccg cgacaaagct tgtatccttt atcattttgc ttttctcttt 2767321 ctatttattt ttatcagggc ataacgcgcc cggaggaggc tttgtcggcg gactgatcac 2767381 gtcctcttcc atcgttctct tgctcttggc atatgattta aaaaccgtgc gttccctttt 2767441 gcctgtcaat ttcatttatg tcgcgggagc cggccttctg ctcgctgtat taacaggcgt 2767501 tggctccttt gtcttcgggg ctcctttttt aacccacaca ttcggatact ttcagctgcc 2767561 gatccttggg aaaacggagc tcgccacagc gacgatattt gatttaggcg tttatcttgt 2767621 tgtcgtaggc ataacgatga ccattattca aacgattgga gaggaagaat aatggaaatc 2767681 ttaatggctg tattagccgg tattattttt atggctgcta cgtatttgct gctgtctaaa 2767741 agcctgcttc gcgtcattat cggaacagca ctgttaagcc atggcgttca tttaatgctt 2767801 ttgactatgg gaggattaaa gaaaggcgcc gctccgattt tgagcgagca tgccaaatca 2767861 tttgtcgatc cgcttccgca agccctgatt ttgaccgcaa ttgtcatttc ttttggcgtt 2767921 acgtcattca tcctcgtcat ggcctttcgc gcttatcagg aattgaaatc ggacgatatg 2767981 gatcaaatga ggggaaatga tcaacatgaa taattttgtt attttgccaa tcctgatccc 2768041 gcttttgtcg gctattcttc tgattttcat gacgaagaat cttatgctca tgagaatctt 2768101 cagcacggcg gcatcggcca tcgggattgt gattagcggc atacttgtac agactgtctt 2768161 cacaaaaggc atccagacac tcagcctagg cggatggaaa gcgccgtacg gcattgtgct 2768221 tgccgcagac caattcgcca gccttctcgt tctcacaaca gcgatcatcg gtttattggt 2768281 tgggctttat tccttccgtt ctgtcggtga aaaacgggag cgctcctttt actactccgg 2768341 cgttcagttc ttgcttgccg gcgtcagcgg agcgttttta acaggcgatt tatttaatat 2768401 gtacgtattt tttgagcttc tgcttattgc ttcctatatg ctgattgtat taggcggcac 2768461 aaaaattcag ctgcgggaat cccttaaata tattgtgttt aatattgtat cgtctgccct 2768521 gtttgtcata ggggtcggct ttttatacgc tgtaaccggt acgttaaaca tggcggatct 2768581 tagcgtgaaa atcagcgaat caggacaaac cgggctgatc actgtgattg gtgtcctgct 2768641 gcttttggta tttggcatga agggcggaat cttccccctc tacttttggc ttccaggctc 2768701 ttattacgcg ccaccggcgg caatctccgc gttgttcggc gctttgctga caaaagtcgg 2768761 gttatatgcg attacgaggg ttttcacatt gatttttatt cacgatacag cctttaccca 2768821 tcagttgatg atttggctgg cggcgctgac tgtgattttt ggtgtgatcg gttcactcgc 2768881 ttattcgaat gtcatgaaaa ttgtgatcta taacattatt accgctgtcg gcgtgatttt 2768941 gttcggtgtg gcagtacaca cccccgcatc cattcagggc gcgatctact atctgattca 2769001 cgatatgctg attaagggcg ctttgttcat gctggcaggt acgctgatcg cattgactgg 2769061 aaccgcgagc ctgcataaaa tgggcgggct gatcaaacgc tatcctgttc ttggatggat 2769121 gtttttcatt tccgctattt ctcttgcagg cattccgcca ctgagcggat ttgtcggcaa 2769181 atttaaaatt gcagagggcg gcttcgcaga aggtgaattt acgatatcca tgctgattct 2769241 gctttcgagt ctgcttgtac tgtactctgt gctgaggatc tttatacatg cgttttgggg 2769301 cgaagaaaaa gaaacgccaa aaccaaatca tcgaacagct aaaggacttc tttatccggc 2769361 agctattttt ctcttgctgt cccttctctt cggattgggt acagaatggg tgtcgcctta 2769421 cgttgatcaa gcggccgaga cgctgctgaa tccggaaaaa tatatcgaag ctgttctgaa 2769481 ggagtagatc gcatggcatt tcaaatttta ttaaatgtgt ttctcgcttt ttgctggatg 2769541 ttcttaagca acagtccaag cgccgcagga ttcattacag gctatattct gggaatgctc 2769601 tctctctttt tcttccggcg ctttttcact cgccagtttt atctatggaa attgatttct 2769661 attatcaagc tctgtttcat ttttataaag gaactgtacc ttgccaatgt cagtgtgatg 2769721 aaatcagtct tatctccaaa actgaatatc agaccgggta tttttgcttt taaaactgaa 2769781 ctgacgaagg actgggaaat caccatgctt tctctgctca ttacattaac gccgggaacc 2769841 ttggtgatgg atatttcaga tgacagaaca atactttata ttcatgcaat ggatatcgag 2769901 gatgcggaaa aagcgatttt tgacattcgg gagtcatttg aaaaagccat acaggaggtg 2769961 agccggtgat gtttacgctg atcctgcaaa tcgcgctcgg cattatggca gtgtctacct 2770021 ttttgtatgt cattcgtgtc attaaaggtc cgactgtgcc tgaccgggtc gtggctctgg 2770081 atgcaatcgg catcaatctg atcgcaatca cggcgcttgt ctccattttg ctgaaaacaa 2770141 gtgcgttttt ggatattatt ttgttgctgg ggattttatc gtttatcgga acgatcgcat 2770201 tttccaagtt cctggagaaa ggagagatta tcgaaaatga tcgaaaccgc taaggtcgtt 2770261 gtggctgtat tcattttgct gggtgctctt atatgcctca ttgcttcatt tggcgtactt 2770321 cgccttcccg atgtgtttac acgcgctcat gctgcttcta aaggctcaac attaggtgtc 2770381 aatatgattc tgctcggtgt cttcttctat ttgtggtttg tgacggggga gctctccgct 2770441 aaaatcctgc ttgggattct ctttatcttt attacgtcgc ctatcggcgg gcacttgatc 2770501 tgccgtgctg cgtataactc cggcgtcaag cttgatgaga gaagtgtgca agatgactat 2770561 aacggaatca gaaactttgt gattaaacga aaagaggatt cttatttata aaaataagca 2770621 gccggacagg cagagttccg gctgtttttt tatttcttga tgacagccag cgtgcatctg 2770681 gatatacaga tcagcctctc ttgctcgtca tatatgtgaa tatgatagac aatcgtcgtt 2770741 ctgcctatat gaacgggctc ggctatcgcc tttaccgttc cttcctttac agattttaaa 2770801 tggttggcgt taatctccaa accaacacaa gcttgcgttg tatgatcaat caggttctgt 2770861 gcacctgcgc tcgccgcggt ttccgccagg gccactgaag cgcctccatg caaatatccg 2770921 aacggctgta ccgtccgatg atccaccggc atgaccgcaa cgcatcgttc cgctgtgttt 2770981 tcaacaatct caataccaag cgcttcaagc aatgtgtgct tcatatccat ctctacaccc 2771041 cccaacattt aaagtacacc gtctgatttc gcaatcaaaa ccgcttccgt ccgtgaaccg 2771101 acattcagct tattgaaaat cgatgtcaag ctgtattcaa tggaccgctt gcttaaatga 2771161 agggcatctg cgatttcttg gtttgtaaat cccttttcaa cttcttgaag aatcaggcat 2771221 tctctaggtg tgagcacatc ttgttctttt tgagaggaag gagccggctt tgttttttgc 2771281 tgagtcatca gctgtttaaa gtaagcaaaa tcgactaaaa tttctccgtt gagtacgtgg 2771341 tatatgtatt gggtgatctt ttctttagat tccgttttgc tgatggcacc gtgcagaccc 2771401 gcacgaatcg cttcctcgaa ataatcctcg acctcataac cggtatacac gataatttta 2771461 caatgaggat tctcttgtaa aatctgttta gaaagctcca tcccattgac ctcgccgcct 2771521 agattcagat ccattaaaat gagatcatat gacgagaaat catgctgctt gataaactgt 2771581 tcgctcggtt caggactgag acaatcaaca gacaaattcg aatccgtttc caaaattgtc 2771641 ttggtgcctt ccatgacagc cggatggtca tcaatcacta gtatcttttt catgttttcc 2771701 tcccttttac tcactctttt ccattttata aaaaagactt ggcctgtgcc aagtcgtttc 2771761 cgttataaat ccattacaat tcgatttcaa tatcagcctt aaagcccttt ccttcacttg 2771821 tttcaatccg aaggcgccca tctaaagccc tgactctctc cttaatgcca gaaagcccca 2771881 tgctcatgga atgctcagta tttttttctt gatcaaaccc aacgccatcg tcctcataat 2771941 gaagaacgat tttgttttga atactgatga gcataatcag cacatccgtc gcctgagagt 2772001 gcttgaccgc attagacaga aactcttgaa tgatccggta caaattcagc tgcgaatcca 2772061 gatcaaggga agccgtaaat ctcccggtat ttaaacggat atgaaacgga acccgctcct 2772121 gctgctgcgc caccagcttc gacagcgcct tcaccaatcc aagatcatac agaagctgcg 2772181 gccgcagctc atgacacgtc tccctcgtca tcgaaatcac atcagacatc tgctcattca 2772241 tctgtacaag cttgtcctgc acctcttcac ggcacggatt atcatccttc ttgaaatcac 2772301 ccaaaaacag ctcacactgg cgttttaagg aaatcaaatc ctgaagaacc gaatcgtgga 2772361 gatcgcgggc gagtcctgaa cgctgttttt cttcgattgc aaacattagc tttttcagcc 2772421 agatggggtt ggttccctct tgttttaagt ccttcaaatg ttccatgagc tcctcaatat 2772481 gcaggacatt ttccatggac acacttgtat aaaaagacag tgttttcagc cacgatattt 2772541 catcacgtgt tagccgggga gtgttaatat tagataaaca aagcagaaca taagaactac 2772601 cgcctcgttc accaactttc ataagaaagc cttgattgac ttctataatt ttcccaattt 2772661 ctgaagttac gttttcaaat tcctcttgat aaaaattcca gtccggtcca acttcatgct 2772721 tatctaaaaa tatcactttg tgatcaggag taacctcaaa ggtataagct ttgcttacaa 2772781 gcaaaacatc cagtatagta tttttcagtt ctttaaaaac ttgttgaaga gaagttacac 2772841 ccctcattag ctgagtatat ttaaaaatac tgtcctgata gttgaatttt tcggagaaac 2772901 gttttaaccg aaatttaaaa tccatgacct ctttaaaata aaagacagcg aacatgacaa 2772961 cgaaaaaaaa tacagtttga cgcacagggt tcatctggat gtccattaca tcaaacagaa 2773021 ctaatgcacc aactattaga agagttggta tcatggcaag tagagcatag tatctcattc 2773081 ttcctaagat aaactctata tcaaacatct tattggctac aaattggtat actaacccga 2773141 acggaattag tactagtaat gacgccgaag ctaatgccgg gaaaatataa ttacctgtaa 2773201 atattattgg aagaacaaaa aatatcaaaa aaggcgcaaa tgaaagagtg tttgttaaaa 2773261 ttagtaattt aagaataaac gaatgctcag catatttata tttattaaga tgtaagtata 2773321 tcgctgaaaa agaaaataga gtcaaagttg caaaagaaac caaattaaga gttgctaaaa 2773381 aatcaatatc tacttgtaaa tagtcttgaa aaaactcaat accaagatta aatattggta 2773441 tgatataaag aaaagaaatt ctattcaaaa aagttttacc tatttctcca aggtatcttt 2773501 gtataaattg aagataaaga ataggagaag atataaaagt aaacaagtta atataccgat 2773561 tgattatatg tcctctaaat ggtccgcctg cacttatata tgctatcgaa atgtctaata 2773621 acaatagaat aagaatatag gcagcaaatg atctcctttt tttatttact ttaagtatat 2773681 aaaaaataca tattatgctt aaaaaataaa aaaacaaagg aagtacgaac agaaaaaaac 2773741 tataaggtct atttagagta actaaatcaa aatctttgag atgaatcttt tttccacttc 2773801 tcaaaatatc cagactgtta atatgactca aatatcccca tttcaaatgt ttgtctgaag 2773861 gtttttcttt attaattttt aatatgatgt ctccctgtct cagaccaaca aattgtccat 2773921 atgaagattc cgatatttct tctatcataa attgactttt atcattttta tgaatcttag 2773981 tcccaataat aattccattc atactgatat aagttgtata gcttatataa aggatactca 2774041 aaacaattac agctattgtg aattttttta ttaagttctt caatattaat ccacctatta 2774101 atcaccccat tgacgggtta ttggatcagc cagataataa tcattataag ctttaattat 2774161 tgtttcagtt tcttgcacat caaaacctat aaggcaggct tctttatttt tcaatttttt 2774221 taaagcctca ggataattta aaaagtagtt aattaggtct tgcatcttgt atcccccttt 2774281 gtataactta ataagcattc ctttattagc tctttttttc tttatctaaa tttaattgtt 2774341 ctatagcaga aatacatttc tgtttatata tttccaataa taccgaaatg tattgagtaa 2774401 ctcccgcttt aattaatttt tcttggaatt tctctttatc aagtaacgat ttataatata 2774461 agtctttatg tgaaattaag tataataaat cttccgaagc atcattaaaa aggcgcttaa 2774521 gatataagta aatcagtgta tgtttgtttt tttcaatatc actgcgattt ccggataaaa 2774581 gaacataata atctccagaa atttgagcta taatcccttt atagtaggaa tatctttcaa 2774641 ctgtttcatt atattctcct gtagccaata aaacacctgc tacatttgct agtgcaatca 2774701 gacttccaca ttttaatcta attacttcta aactttcatc ttctgtttta gatttattag 2774761 tgatatcgtc atgttgacct tgcatggcct cgtttacgta ttttaaaaca tatttaaaaa 2774821 ttagaggatt gttatttaat gaataaatac tcgttaatcc tactgtatac aaggaaagtg 2774881 ctgcatttaa cgactccgag cgattaattt tcatccataa tgcatggtga ttatcttcat 2774941 cttcaagatc atccataata tctgatgaaa gaataagaat ttctattccc gcgccaagcc 2775001 ttgttgcaac atctaaattc tcccctccaa aaacaacata atgtaagatt gtggattcag 2775061 caaaggagaa tgtttcttta gaatcaataa atgagtaaag aagttgtgac aaatcctcgt 2775121 taaatatgtt ttgctccaca atctccttca ttttctcctt gatccggaca gaatctaaac 2775181 atatctgctc aataacgact tcccccctcc cattccattt tactaaatgg gacatttaaa 2775241 ggacagcagg tttttcgttt tttaacaatc atataatact ttatccattt attgtatcgg 2775301 tagaacgaaa aaaaagactt gtttccaagt ctttttcacg aaattttcat tgcataattg 2775361 tatttatcga gttgatcaat gcttttgtta atgtttcgta atgaatctgt cgtttcttta 2775421 atatcaagtt cgagtcggaa taacaattgt tttacttctt caagtttctt ttccatcgtt 2775481 tccacactcc tttttttgaa agatcaatga attgtgtatg gtgaacgagt cctaggtatt 2775541 tgatctgtta ctaatagtgt gtctgctttc ggctcatttt tcaccgaaaa gtatgcaaaa 2775601 aagtcctgcg tgacaccgca aatctcaata ggtccttata ctcaaaggaa tcacaacaag 2775661 aacgggacta tctttctatg cgaaagagcg tttatatgtg ctgaaattga gaaagattct 2775721 taatctcctt gattttaacg ggtttcgcat tttcactaag caagactata gtccttcata 2775781 ccgtattttc aaaattgaat atgcgattct tggcgtttcc tgaccgacaa acaccgaaaa 2775841 agaccgcaac gctaaagttg tggccttttc gctttgtcat attcggcaat tagggatcta 2775901 tacatataga aacatccttt tttgcgaggt gctcccatga gatatcgtta tccctggttt 2775961 tacgtgtatc cgtatgaggt acgccgtccg cccgctcctg ccaacaatat tgataccttt 2776021 atccgttcag cgaagcaggc cgcagggata tttgcggatg cccagctcgt tctcagccgc 2776081 attgcgggct cgcgggagct ttcgcgccgc attctgaccg cagccgaaca gtctgataaa 2776141 caaactataa ggcgcctgat caaacaaatg ggcgtccggc atgaagtgga tacggtcttt 2776201 aatcccgacg gcatctatat cagccttatc ggaacgcaaa gccgaatgat tcttgctttg 2776261 cggtggtcag aggaccgcaa tcattttgcg tccataagat tatgacacca ttccagagcc 2776321 tctaaataac attcatacgc ttcttctttg tccagttgat tgcctaattc tgagcaagtg 2776381 tcccagttgt tgctttcaat taatttcaca agctcaagca tttggtagta gtcgttttga 2776441 tggcctaata atgcttgccc gacttcatct tttaaaggca attcttgaac aatttcctct 2776501 atttctctat gcaggagggt gtctatgaga gaaaacattc cgatcagcat ataagaagca 2776561 ggctgcggcc gggatgtctt tctcgccagc agttcgcaaa gctttgctct tatcagagaa 2776621 atcttaatga tttcgtgctt gctggaatgc cctttcctgc ttaaatcctt aaaggaaaga 2776681 atatatatcc accgtttgat ttcattaaat cccagcagca taatggcctg ttgaatgctt 2776741 tcaattttct ggctcaaacg gctgtgggat gagtttaaaa attttaaaat ttgataggac 2776801 agtgataaat cccgctctat gtactctgtc acacgcttta tgttaggctg ctctttactc 2776861 agttcgttaa gcagttcata gtaagaatag aaatgagtcg ataggtcatg cccgctgatg 2776921 atgcgcggct cgctgaaaaa gtagccttgg aataattgaa agccgtcttg gaccgcctgt 2776981 ttatattctt ttcgggtctc tactttttcc gctaaaaaaa tcaggccgcg gcagccgtag 2777041 gtttgcaaaa ttgttctgcg ttccattcgt gttgttttga gaaaatcaat tttcaatata 2777101 tcaatatagc tcatgagttt ttccagtaag tcctcatctt gcggatttat tgcataaaaa 2777161 tcatcaagcg ccagcatata ccccattttt ttcaattctt tgcatctaga aatgagggcc 2777221 ggcgtgatcg gtatatcttc aaggatttca atgacaagct gtttcggatt gaaggaggtg 2777281 ggaagattcg aaaacatcag gctttccgta aaattaacaa aacagcgttt cccttccgtc 2777341 agcttctcaa ttccgatgtt taaaaagctg ttgatcacca aatctgttgt tgcctgatcg 2777401 ccgtctttag cgctatacac gttctcttcg ctttctctat acagcagttc ataagcaaca 2777461 acctgttctt ttctattaaa aataggctgt cttgcaacaa acaccctcat tgatttatcc 2777521 cccttacaat acgcgcggct ttcaccccta agtatatcaa ataatttgac gaaaattgtc 2777581 taaacatgaa aaataatata tacataaaga aaactggccc ttcgcgaatg aaaggccagt 2777641 ttttctttat tcttcctcaa gctcttcttc aattctgctt ttcacttcgt ggatccgctg 2777701 cattttattg ctccagcagt cctcgcttaa atcaaccggg tattcctccg gcttgctgat 2777761 tctcttatat tcctcccaaa gcaggctgag gttatcctgc acatactgct gtatgtctga 2777821 aatctcaggg ttttggtagc aaagaatacc cttctcaaaa atcagttcat gaagatcctt 2777881 cgcataaaaa ttcgtgacaa atttgctgat gaatgtatga accgggtgga acattctgag 2777941 ccgcttctga tcattcacct gctcatcata aagcgcaata tagtcgcctt cagaatgatg 2778001 gttggactga ttaataatgc ggtagacttt ctttctgccc ggtgtcgtca ctttttcagg 2778061 attggacgaa attttgatcg tgtcgaccat tttcccgtct tcttcaatgg caacgagttt 2778121 ataaactgcg ccgagagccg gctggtcata ggcagtgatc agcttcgtac cgacacccca 2778181 gacatcaatg cgcgctccct gagcctttaa attcataatg gtgtgctcat ccaaatcgct 2778241 tgaagcaatc accttcgcat ctgtaaatcc tgcttcatca agcattttcc gggctttttt 2778301 tgacaggtac gccaaatcgc cgctgtccag acggatgcca atgaaattaa tgcggtcgcc 2778361 gaattccttg gcaaccctaa tcgcgttcgg catgcctgaa cgaagcgtgt catacgtgtc 2778421 aactaagaag acgcaatcct tatgtgtttc cgcgtatttt ttgaaagctg tatattcatc 2778481 gcggtaagcc tgcacaagcg catgcgcatg tgtgccggaa accgggatat taaagcgctt 2778541 tccggctctt acattgcttg tcgcgctaaa gccgccgatt aaggctgctc tcgctcccca 2778601 catggccgca tccatttcgt gcgcccgtct tgttccgaat tcaagcgcaa cttcatcacc 2778661 gatgacgcct ttaatccggg cagcctttgt tgcgattaat gtttgatagt tcacaatgtt 2778721 gagcaaagct gtttcaatca gctgcgcttc taccaggggt gcctccaccc tcataatcgg 2778781 ctcattgtta aaaacgagtt ctccttcttt catggagtaa agtgaacctg taaaagataa 2778841 gccgcgcaaa tattcaataa aatcttcatg atacccgagt tcatcctgta aataactcaa 2778901 atcgctatcc gtaaacttga aattttccaa gtattcaatg gctttttcca agcccgcaaa 2778961 tacggcatag ccattttcaa acggaagcct tctgaaaaac agctcaaaaa tcgctttctt 2779021 ttcatgaatg ccgtctctcc agtacgtttc cgccatattg atctgataaa ggtctgtatg 2779081 taatgacagg ctgtcatctt taaatccgta ctctaacact gtttttcccc ttccttactc 2779141 tgccacttgc gctccgatgc tgtttgcaaa atgggaaaga gcccatgcgt gcccctcctg 2779201 attaaagctg gcaacagctt gtttatgcac aacaatccga aaacctttgt tgtatgcgtc 2779261 aacagctgta tgcaacacac aaatatctgt gcagacaccg gcaagatgca gttcgccaat 2779321 ctgccgctct ctgagtttga gctctaaatc agttcccgca aaagcagaat atctcgtttt 2779381 ttccatgtag taaacattag gttcatgttc atgtttctga tatagaggca aaagctttcc 2779441 gtacagatct tttccttccg tgccttttat attatgcgga ggaaaaagac gggtttcagg 2779501 gtgatattga tccccttcat catgagaatc tactgctaat acgacgtaat caccgtttgt 2779561 gatgaattct ttagttaaat tgacgatcgc ctcttcaatc attctgccgg gctccccgca 2779621 ggtcaatttt ccgtcactcg ccacaaaatc attcgtataa tcaatacaaa taagtgcttt 2779681 tttcatagcc ggcctccccg ccatcagtat gagaacatta tatcttatct ccagttgtaa 2779741 gtgaattgcc atgaacaaaa agacaaacgg tccgtttgtc tcttacgatt tcagtactga 2779801 ccgattataa atgtcgtcct gaatatatat caattcacga ttcacagcga tatcagccgc 2779861 aatgacgatg cctaagggcg tatgaaactg gagatcagat acaatcttga aaggcactcc 2779921 gtaccggctc gccatttgga tataagaaga gtaagactga tactgaagct ctccattaat 2779981 caaaagggtg acgttatggc tgtttttcag ctcgtgctct gcctctttat acggtttgct 2780041 tctaagcacc tgtcctttcg tcagtgccaa aacgactctt tctcttaaag agcctaaaaa 2780101 caaatggcgc tcgtcaggct ttgtctccaa aggcccatac attccttgct gcaaatagag 2780161 atccatttta tcttcactca aaagcctgtc ctcccgtctt gtttgtcttc attatcacct 2780221 gatcaggcag gagctaaact ttcaagcgcc gtttacattt ctgttaccca atgaatgatt 2780281 tttttggcca gctcaccagc aggggtttcc tctgtatgcc ggcgcaacga cgcttccagc 2780341 cgttcaggca gagttgcttt atcttcttca taggaaatga tcgtgctcca ctccagctgc 2780401 ggtaccgcta caagcgtgcg cagttctttt ctgttttcat gcagatacac gtccgtgatc 2780461 attccggttt gcgtattgat atttgctttt ctgattttca taacatgacc tctctattca 2780521 aagactaccc atattataca ataaaaaagc aacagcctct tgtgaaaagg ctgttacccg 2780581 ttaaacgaaa ctgtttcatc agtgatatcg gcatctttga agagagtttt actcgtttgg 2780641 ttgttaatct tcacaaaatc accaagctga aatgtgcctg accccgcccc tgaatgagcg 2780701 acgcttttgg gcgaaatcgc aaatacgtct ccaaagcttg ccgcggcatt atccgtaact 2780761 gacatgatat aaatcggccc cacaattgca ggcatttccc cacctccgca ttgatttaca 2780821 gcatcatatg caaggagccg ataatggtgc ccgcctattc agctggcttt gcgttttcct 2780881 cgagtcgtga ccgctggcgc agcttgatca agcggacaat attcaggaag aacgccttca 2780941 ctaccgcata aaccggcacc gctaaaatca tgccgagaat tccgccgaag cttcccgctc 2781001 cgattaatag caaaataatc gtaagcggat gggtattcag ccgctttccg atcacaagag 2781061 gagacagcag gtttccgtcc agctgctgaa cgatgacgac cacaataatc gcaaacagcg 2781121 ctttggccgg cgagtccata aaaccgacaa tgacagccgg cgcggcaccg agaaaaggcc 2781181 cgacataggg aatgatattg gtaatcgcca tgacaatccc aagaatcagg gcatacggca 2781241 gtccggcaat taaatagccg ataaaacacg ctgttccgac aaaaagacag attaacagct 2781301 gcccctggaa atatgccgca agcgtatcgg ataaatcttt aaaaatcttt aagccttctg 2781361 tccgataaga agccggtaga atttttactg ccaaatgcgg aaagcggtgt ccgtctttca 2781421 gcatgtaaaa aaggataaat ggaacagtaa taataacaag cgtgatgttt gtcacgacac 2781481 caaacaccgc agataaactg gacgtgatat tttgcggcag gttttggaga aaacttgtca 2781541 atgactgttc aatttttgat atcgatacat aatcctggtt catcatccag gtaaaccatt 2781601 gagaatggga caaatccttt gtcagcgcct gaatctgttt tatataatca ggaaggttgt 2781661 taaacagccc tgtcacctgt gcggtgatga taggtccgac tgacgctgaa ataaaggcaa 2781721 gcaaaccgat aaacagtaaa tagatcaata gaatggataa tgtccgcgga atttttttct 2781781 caagcaggcg gacgaccgga ttaaatatga aatacaaaat tcccgcaatt agcatcggga 2781841 aaaacaatgt cgagataaaa acaataaacg gctgaaatac aaatgaaact tttgttgcta 2781901 caaaaataat cagcaaaaca aataaaatct gcaatgtcca aaaatggact tttgatttca 2781961 acaagctttg ttcctcctag tttttctttg tctgtcagat aaaagaactt ataccccatc 2782021 attgtaacaa aaatgaactc atatcagaac tcttaatata atgaaaggag tgttggtgat 2782081 gaaggccgtg acatacgata cagattcaga actggcttat atctatgttc ttcctccgaa 2782141 aaagaacagg aatgtacgga ctgaggagct cagagtcaat gattgtctcc tgctggatat 2782201 cagccaagat ggcaaaatcg ccggattcga atgttttggt gaggcagcac acctctgtgc 2782261 cccatttgcc gggaaatccc ggctgtatgt aaaagattca gacggttatc attttcgggt 2782321 ctgccagcat gcttcagtcc gttcctgcta tacggtgtac cgtgtcactt tctgtttttc 2782381 agatggtgac tatcaggaat ttgccggctt tgaccttgat ggaacaatgt atcatagtgc 2782441 gtttttacag cgcttaactg aaaaatagga cgtcctgttg tacgcctatt tttcatgcgc 2782501 aagcactgtt agacccgctc actgtaatct ggggtgacgg aaatcatgtg ctggattctg 2782561 atcaaacaaa cagaatttcg ggctccttca attgtgatat ggtcaggttt tacatcgatc 2782621 agtctgcctc tgaccgtatc tcgtactgtc tgtataacga accttgagcc gatgagcttt 2782681 ttaatggtct gatagacata aggatcgact aaagagacca gttgcggact accttggttg 2782741 accatacttt tatccccttt gtgtgtttta tctcagctta tgccgcgctt atggataatg 2782801 acacaggctt acctgataaa acaaaggggt gcggagattt taggagaata cgtttggagg 2782861 cgggtgtaaa ggaagtatcg atgaagcgga gacagcgaag aaagctggcg ctgttccgta 2782921 cttatacagg ctttatcacg gatgcctggg cttggtcgat taattggtcc agcttttcta 2782981 ttttttttcg tgcggttgaa ggatcaattt ggcggtaatg atggtggccg cccggctctt 2783041 catccagttc gtccgctttt ttgacaatct gctgcagtgt gtttttatct aattcgcctt 2783101 caggcaaata ggaatctgta tgaagcaaaa tggctagtgc aatctctttt gctgctttcg 2783161 gttcctcgcc aagccgaatc agaagtttat gcgcccgttc cgccccttta atggcatgaa 2783221 tgtcatttct tttgtatttc tcataatccc actttccgtc tgtataccat tcataatggc 2783281 caatgtcatg aagcagtgcc gcttttgctg ctaaatcagg attaatgtca gccttcacag 2783341 acagcctgta tgcatgataa gcgcaggcaa tcgcatgtgc cacgccggaa cgctgaagat 2783401 atttttgtgc aattggatgg gtgaaaacat ccattaatgt aacctttctc atggaaaccc 2783461 ctcctttaga tatttttaga atcctaacat aatttgcaga gaaactcaat tcttatgtca 2783521 catcattttg atcttcttat catcattgtt ataccctaaa agcaacgttt cagtcagtat 2783581 atgcggctgt tcaataaaat gcgctggctg cagccttttg tataaaaaaa agagcagaaa 2783641 atatctgctc tacaaaaact ctttaatatc ataaatgcgg ccgttttccg tccctttttc 2783701 tagtaaagaa agcagcgtgc cggcaataaa gtccggactg cgaaggcttc ctgtttcatt 2783761 taatttccgg aatcgttcaa tgtggtggaa atcctttttc gatgaagaac ggatgacggc 2783821 ctgcatctca gtgtccatca ctccaggtga gaacgaaatc atgttcaccg gcagctcttc 2783881 atcctcctgt tcaaatccga atgtcctcgt aaacatgtcg agcccggctt ttgaactgca 2783941 atacgcgctc catcccttat atggattttt ggcggctcct gaagtaatgt tgacaaccgt 2784001 ctttttgccg ctgtatgaag caaaccgttt tgtaaacagc tgactcaaaa gcacgggcgc 2784061 agtcaggttc agctgataat ggcgctgaag ctcgtcaaga gacgcttcgc cggcacgttt 2784121 gatcggcgtt accattccgg cgttattaat aagggtaata ccagaataac gatctgaatc 2784181 gatggatgag agcaatgttt caaattgctg ttcagcttct tcgagattga tgaggtctat 2784241 ttgatgctgc gttagttttt tgtgagagac atctgttttc gttctggata aggcatggac 2784301 ttcatgcccc ttttctaaag cctgtaatgc aatggcttga cccagccctt ttgacgctcc 2784361 ggtgatgata taaagttcca ttggaaacct ccttttccgt tattattgta cggcacctct 2784421 tttacacaac acaagcacgc ggcctacgcc ttcttgtttt cctgcgctgt gacttttggg 2784481 atgaggaaca cgatgcctgc aattccgagc aggatcagta cgacatagat catcggcagc 2784541 agcaatgatg atgtttcttg ttcatcttct gtttccgttg atgatgtctt tgtcattggt 2784601 ttttcagcaa aagtaattcc aagctgtttc gactgggccg caatcgtgtt ggaatcctcg 2784661 gcatttgttg atgtaaacaa atcttttatc agctcggcgt ccttgtcctt cggtttatca 2784721 aaagtgatat ccttttgttc ctcaggcagt tctgtttttt cttcatagta ggtatcttca 2784781 tgcaaataat tcgtatcgat ttcgatgtct tttttctcat actggtttgg cgcgacatct 2784841 gtattttctt cagtttgggc agccgctgca gagggtatga aaagggaaaa ggagagcata 2784901 caaatcatga tccccttttc catgctgcga tcacgcttca tacgtttcat cgctttctgc 2784961 tgtgtgttca gccatcaacc ggataatcag cggcagagcc acggcaatca ccgtaatgat 2785021 cagcagaact gttattccca ttgtaaacaa gtgcccagta ccgtactgga tgtcgatata 2785081 tactttcgaa accggatctt caaatgtaaa gttcggcatg atcaaatcaa taagcggtgc 2785141 gacatagaat aggatcattg ctgctgaagc aacccagcca gggattgatc cgaatctgaa 2785201 tgccgtccgg atgaaggcag agcttgcgac cagcaataga atcgtaaaca ccgaccactt 2785261 aatcgtctga tcgtccggca gtgaataaat attcaagccg aacaagctga tcataagtcc 2785321 gacaaggata ttcagaattc cgaataacgc tcctttgacg agaagcggtg cgttttggta 2785381 atacgagctg aaatagccga ttaacagact gctgatcaac acaatgacaa ggatgacaac 2785441 cggaggtacc gtctgaattt tttcttccgg aacctctccg ctgattttaa gcggattcgc 2785501 taagtaatca tatacatagc cattgttttg cccgtctact aatgtatttc cgagtatgcc 2785561 gtatacgtca tttcgcacga gtttcgtgga ggcgacattt ttcccccagt tgttgtttaa 2785621 ggtgtcggct ttcgcttgaa catcattaac gctttgctgc atgttggttg tgtaatcaat 2785681 gatgccggac tggcgatcag acaatgaacc catcatgtct gacatttgca gcacttcctg 2785741 gccgaccgta tcttggacac tcagtgccat ggtaccagac agcccatcgt tgctgaacgt 2785801 cgcagattcc tgtgttgcgc ccgttacaag ctgttctgac gcttttgcgg cactttcaga 2785861 gattttcgtc agttcgtcga gaacacctgc ttgagagtca cggatatagc cgctgtagtc 2785921 gtccgcaaat ttggtcatgc cgtcgatgaa gctgttaata tcctcatctg tttgcatcgt 2785981 gttgtttttg agagcttccc agctggctga ttcttcaggt gtgagagcca ggactgattg 2786041 gacgttgcca tcttgctctt ggatgacttc acctttaata atagtcaaag agcctagatc 2786101 cagattatca tttagcgtag acttatataa atttaaagag ttgtaatact tcatcaagtt 2786161 agaaatatta tcagtttcaa ttctacttga aaaaattgaa cttagttttt ctttctgatc 2786221 tatatagcct ctactctgca aagtttgtat tatttcgtct tccaaattgt atattaacct 2786281 ataagcatca ttgacattat tatcaaaatc aaccaacttt tttgttaagt caccaatttg 2786341 atcatttaat tttgaaactg ttttatttaa ctctttaatt tcttgattta actcatcaat 2786401 atgtttctct agtttgttgt tatgttcctc ttgtttttct tgaagtgcat tttctatttc 2786461 ctctaatttt atcgctgctt cgttcagacg tttttttgca cctgaaatat cagtttcacc 2786521 gtcagctccg tcaccctgta gcccatcact ttgatttgag ccatcgtttt catctgcgag 2786581 ttcaatcaaa gagaaatctg ttttagaggt tcctgtattc tccgtgtttg tatcttgttc 2786641 aggaacgttt tttgaagatt cttgatgttt ttgtcccgtt tcaatgttag tttgaacatc 2786701 attttgtgat ccattatctt gagtaccctc ttctgatgag ccagtatctt catttgttgg 2786761 ctgatcatcg gatgttggaa tatcattcga cggttcttca gtattaggag aatcatcggt 2786821 tgatggttct tcagcatcgg gtgttgttgg tttttcttgt tcaggttctt ttaacccttc 2786881 agagatatct ttaatttcag ttgcaacatt tttgagctca tcccgctgct tctctaaatc 2786941 caattttata tcttcaatat cttccttatc tgtgtcatct ttattatcag atgtgtcttc 2787001 tccatcttcc ttttcgtcgc tttccttagg tttaagtaaa ctaaggcggt tcttcccgat 2787061 attctcttgc aattgattta aattttgata tttaatagct tcatattgac ttttatatcg 2787121 agatagaaat gcattaaaca tgtcattctc aatttttttc atacccattt cttgcaatgg 2787181 cacttgattt tgccttaact tttcagcatt gttcaacgca aggtttgtca gtcctatttg 2787241 tgtcttcgct tggccgatcc cggttgccaa tccgctcatg cgttcgctga actgattcgc 2787301 cttttgctgt gcctggatgg catccagacc tgtccggatt tgctgctgtg ttgaatcctg 2787361 ggctgccaaa agcagctttt tctgattctc ttgatattct ttgtaccttt caactgtatc 2787421 aatgaattct ttcagcgtgt ttttggcttc ctccgccgta gaagcttttt cttttgtcgt 2787481 gccttgcgct tcattcattg atttcttcag ctcatcgatt aagtcttttt gctgtttgat 2787541 ttcacctgct aaatcattag agcttggttt gtaaaagttg tacatgacat tctggaattc 2787601 agattcttta ttgacgatct tgtcaaattc tcctctgatg ttgtccactt tttgcgaaac 2787661 aaaattccag tataaggccg acattttttt gttcattgtc ttttgggcat cctcaagctc 2787721 acgctgaact ttttctttgt taaccgcatt caggttatct tgaatgctga attcgagcgt 2787781 tgccttttga ggatggtctt tgtcatagct caaaatgttt tttgagaagt ctgagggaat 2787841 gtagacaatc gcatcgtatt tctttgaagc gagaccggtc tcggccgcgc ttcggtttac 2787901 gaccgtccac gaataatcag gacgttcacc cagaacggcc gctacttcct tgccgaactg 2787961 ggcggatttg tcctcttcat cagactttac ctcatcactc aatacgcctg tgtcttcatt 2788021 caccaccgcg atttgccggg tagaattgac tgcttttttc gttgggtcgt ctccgataaa 2788081 tcggaaaaac aacaccggca gcagcaaaat gatgatgacg gcggatatta acttgatcaa 2788141 gctttttcgt tgttctgtca tctagcactc tccctttcag cagaacataa aggaatttga 2788201 actttttgct ccttcccgtt ttccacaaca tatccgaagc ccggctgaat ctcaggctcc 2788261 tgtctttggt acgggagagg aatgacattt tgctcagact ttttcatcag cagaatcgcg 2788321 tggcggattt gcttcatctc agtcgtcaag gagtcatagc cttttgagaa ttcgctgtgg 2788381 tttccgcccg ggataaagct gaacccaaga tgagcgtatg atttcatgaa gttagcgaga 2788441 cgatcttgta ttctcgtatc aatcgtctgc tggaatctcg ttatcccgtc aatcatcagc 2788501 acgacttgtg agaatcgcag attttgtgcg tctccttggc ggacggcttc tacatacatg 2788561 gcttctcttg ttttgaaaat gtcttctgct gtttcaatcc actgctcaat atcttctttc 2788621 gtttccaaat atgaaacatc tgattccttc gcataatgag ataagccgcg gtcaatcgag 2788681 tcaaacaggc cgatcatttc ggtttcatca tcaatcagat gttcaagcat gacttttagg 2788741 acgtttgttt tcccgcgctg agtttggcct aaaatcaggc agtgcttatg cttgcccaaa 2788801 tcaaaataga ctgggctgac tgtttcttca tgaagcccga tcggtacaga taaaggcttg 2788861 cgttccagct tgaagcggat agacaattct ctcgtcgaca agctctcagg cagcatcgga 2788921 atcggtgccg gctgctccat tgaagcaaat cgcccttgaa gtttctgtac gtctgatttc 2788981 agctcgttga acatgccgat atcatcatcg gcgtcaacag gcaggaacat ttgcgcgaaa 2789041 taaagctctt ccttttgaat gatgacgcgt cccggaatcg gctcaagatt gaatttcgga 2789101 cggccgtaaa tggaatatcc ttctgattga tccatgagat aatggacaat ctttgttttc 2789161 aagttattta acaatgactg gcggacagca ttcacccgcg ttgctgtcag cataaagtag 2789221 atacccaagc tttgtccgtc tctggaaagc tggacaaatt ccgattcaag ctcatgcatc 2789281 tcatccttga caatgtcaaa gttgtcaatg gtgataaaaa tgaatggaag ctcttcttcg 2789341 ctcagcgcat tgtacatttt gatgtggctg atttcttttt cccggaacaa acgtttacgg 2789401 cggtcaattt cttctttgat gcgaatcatg aacttttcaa ttttccttga ctggtccatc 2789461 aggaagtaat ccgcggtatg cgggagcttc gctaatggca gcagcgttcc gtttccgaaa 2789521 tcaaagatat agacatgaag ctcttcaggt gtgtatacgt ccgcaaaact catcaggaac 2789581 gttgcggctg caatcgattt tccgtagccc gaagagccga agatgccgat atttccatct 2789641 tccatcatct tataagcaat tggcgcctgt ctttgcagat caggttcatc gacatacgca 2789701 aagtggaaat ggtctttttc gtttgaaggg aaaagagtgc gcggaatacg ttccgcaagc 2789761 ggcggcagcc aagggcttgg cagcttctcg attcccattt catcttggat gcgttcaatt 2789821 tcgtcaacta cagcttcgat ttcggtttga acgtcttttt tcgcgttatc ttcggtatca 2789881 acctcagaaa gcgggatcag acccgtatct gtgacgatcg cgatttcatc ctcggtaccg 2789941 tagacttcct ctaagtaagg cgccccgctc catgcagatt ggaacagctc atacacttca 2790001 ttgtttccga cctgcaaata gccgcggcct gttacggtaa tgtttgcggc atcgctgttt 2790061 ttcaaaattt ctttactgtc ggtggcatcc tggaccttga gcgctacttt aaagcgcgag 2790121 ttactccaga tctggtcgtc gatgatgccg cctggcttct gtgtcgccaa aatcaaatga 2790181 acgccgaggc ttcgtccgat acgcgcggca ctgacaagct ccctgataaa atcaggctcc 2790241 tcgcttttca gctcggcaaa ctcatcagaa attaagaaca agtgaggcat cgccacttct 2790301 gctttccctt gcttgtatag ctttgtatag tcattgatgt gattgacttg atactggtca 2790361 aacaggcgct gccttttttt tagctcgctt ttaatggaag caagcgcacg catactgaag 2790421 tttttgcttc cttcaatatt tgtgatcgtg ccgaggaggt ggggaatgtt acggaacggc 2790481 tgcgccattc ctccgccttt atagtcaatt agtaagaaag ccgcttcatg cggatgaaaa 2790541 tgcactgcaa gtgacaagat gtaggtctgg agaaattcac ttttccctga tcccgttgtc 2790601 cccgcaagca agccgtgcgg accgtgtgct ttttcgtgaa ggttcagata cacaatgtca 2790661 tctttccctt tatagccgat cggcactgac agcgacttcg acgattcact tgtcagccat 2790721 ctttgctgaa tgccgatttc ttttacttcc ttcgcatgaa aaagctccag gaacgatacc 2790781 gtttccggaa tggaattcgt aatgccgacc tggtggttca gcgtccgcag tgtgcgtgaa 2790841 aaccgttcgt tatcctcacg ctgatgatga tcgagacgga acggaattct taccgctttt 2790901 ttcttttgta ttaaaatgtc gccttcatgc tcattaatgt agcggacaag agttgtaatg 2790961 ttttccgaca agctttcctt tgtttctgca gcgacaattg tcgagatgcc cagatgctca 2791021 tgctgccctt ctaaatattc gagaatgaca tgctcagaga tcagctgctg attcgtgatg 2791081 acaaatacaa aatgcggttt gaactgcagt ttttctttgt catcttcgag atcacgctct 2791141 ctgatcaatt cgtaaagtga agacaggagc tgatctcggg tttgctcatt ataaataaat 2791201 ccttttgcat aaatatgggg catttgaaat tgcggaagcc acttcatcca ctcccagtct 2791261 ttatactctt cttcatgaaa aataaatacg aaacgcaaat cgtgatagct gttaaagaac 2791321 gacagctgtc cgattagctg gtgaatctca tttttcacaa tttgtgattt accgacaagc 2791381 cccatcggac cttctgccaa atcgaccgtc accggcgcat tacggatatc tttatagacg 2791441 cgttgcatgt gctgcgattt ctccatgagg tcatcgatat cacgattcgc caagtctccg 2791501 ccactcatat tgatttcata gcttgacgga actgttcccg tcccaagccg cagctggaga 2791561 taatccttgc tttcaagtga tttttcccag atccggtcac tgatttcact tgttaagtat 2791621 ttcatttgtt caaatgaagg aaagtgaaat tcaagaacct gcttttgctt ttcagcaagt 2791681 gcctgaagct ctttccgctt attgtctaag taaagcttat atacacgctc ccgtttttcc 2791741 tcgcgttttt tccgctggtt tttatcacgg aaatattgca ctgtcgaggt aatgagagtc 2791801 atcataaaca tcgccaaaga aacgagtata aatatgccgc gcggctggat gatggcaact 2791861 acgcccatca cgatcagcat cacaagcgga ggcaggatga cgagccacag ccctctgttg 2791921 gtttgatcgc tctcctgaga gggaaaactg aaagaaacgc ggtcatccgg cagatcgtat 2791981 accatccgcg gcgttcttct gtactgcgga tattttttct gcatctctgt actcggtttg 2792041 accgtttctg ttaacgctgt ttcaaactgg gcataatgaa caatttctaa aaggtcttgt 2792101 tccgtcaccc tcatttgcgt gaagttccag aatatttcat cccccggctt gagcggcgta 2792161 ttggcgttga ttttctctcc gttcaagaag atcgttccgc tttcagggcg gaccgaccag 2792221 ctgccgcctg cacggagcaa agaaaacgtg ctttgttctg caaatgcaaa atcttgcgga 2792281 ttcagataaa tatctgcatt cgttttttct gaggaacata caatttcatc ccgatttccc 2792341 gtaaaataaa cggatttctc aggttcactg cccgtcaata tcaagcgtat atcctgctga 2792401 tccgtttgga gagtaaatga tatatccgtc tcaatcgtgc cgagacaatc atttcccagg 2792461 aaaacttcgt attggccgcc ggattccttt cttttaagag aaatcactcc gctattaaat 2792521 ggaatggtgc tgatcgtaac agaatccttc acatcaggcc ctatggtcac cggatgagac 2792581 gacgggaggt tagacagatt taatttttga acgttatttt ggtaaaaaac ccataataga 2792641 ctcaaatggc gaaccccctt acggccgaat ggcagcatgc gatgacctgc gcttcatgtc 2792701 tcacgttatt tgtcatcttt tttctcatct ttcttttctg tttctttttt ctcgtcttct 2792761 ttttccttct gttcttcttt tttcgctttt tcctcggctg cggctttttc ttctgccgct 2792821 ttctcttctg cttgtttttc ttcgtctgtt tgtgtctgtt cttcgcttgt atcgactaac 2792881 gatgtttcag aattagactg tttattttct tgacgttctt tttgggcttt ttcaagctca 2792941 ctatttactg aatcaagttc tttttgtatg tcttcatcat ttgtatcctc agataaaagc 2793001 tgctgtttat atttagctag ggcaaagtaa atataatcat tgtattccag cttacggccg 2793061 atactgatcg cttctttgta ttctcctcga ccataatcaa tccaatataa gaaatgctga 2793121 gggtctgatt gaagggtgac taaattattt tctatatttt tggtttttgc actccccagg 2793181 ttttcgacct caacatagga cgtcgccagc tgatactgca ccgattcagg caggctttcc 2793241 gcatcgtact tggacagtgt gctgatgact tcactgtact gcttgtttaa gaacgcacgg 2793301 ttgctgtcca ctatcgcctg gtgctttggc tgcgcgaaaa ataaggcgta catcgaataa 2793361 ataagtgccg gtacaagcaa aacaatgagc cccaggccga tatatcgctg gatgttccac 2793421 ttctttctcg ggatatgtat gtatgttttt gctttggctt cgagctcatc aatatgggtt 2793481 tgaatcagct cgagcaaatc atcataggat tcagcatcta atatcgcctt tgcctctgcg 2793541 gagaacgtca gcgtttcatt gaatttcagg tagtcttcaa acgcaaaagc gccgtcaact 2793601 gccaaagccg ctgccgcttt cagctcctgc catactcttt cctcatcacg ctcgtaagga 2793661 ggaatgcttt cttttactcc ataatggaga aaataaggcg taagcccttt atcgaataca 2793721 atgttttcag gagcgacaat caaattcagc ctcgacagat tgtgctgctg tacggcttga 2793781 acaagctgat aggcaaactg ccatttactt tttttatcct tagctttcat gaagcggaat 2793841 gctttatagg aggagggagg ttggattgtg atgattactt catcatccgt cacatcgatt 2793901 tctttatgaa aaaatggatt tatatctttg atcacgttag cttcaagacc gtcgagaagc 2793961 tttatttttt cccgttgaaa ggtaaatgta tagccggcat ctgttttctc ggcaacagct 2794021 tctaattggt tttctaaata tgatttttgt tcacctgaca ttcaaccaga tcctttcata 2794081 atatttcaag ccggtctccg tttgtaatgc cgcaatcaga cagcttgcat tctccggaaa 2794141 acaccttatc cttgttcacc actctgatcc agtgcccttc gcgcggaggc atagatacgc 2794201 tttgggcctg ccaagcaata tcaattactt ttttcaccgg gtggtaatct gacaatctga 2794261 gatcaaagac actgccgtta taatgtttca aatctattgt aatatcaata tacatttagg 2794321 atcaccctta catagaaaga gcgccgtctt cttttgaatc aggcgctcct tccctttcat 2794381 actgttatcc gcggatttga tttgcgatgt cttggtcagt agactcaagt gtatttgctg 2794441 tttgatcaag ctgctgattc acatcttgaa gcaaatctga cattttgata aatgaaggtt 2794501 tgagctgctc gtattgatct gcgaacgctt cgcttgaagc accttcccac atgcttttca 2794561 aatcagagat cattcggttt aaacgatcaa cctgatttaa tacttcttgg ctttcaacgc 2794621 cgtattgctt cgccatcgct cttagctctt cgggtgtgac acgaattaat cctgccatat 2794681 tcctcattac ctcctgtgcc atcagcctaa atatgggcta attcacttat ttttagaacg 2794741 tcattattat aaaaacagtt tttcggcata gtcaaacaaa tatgttttaa ttttacaaaa 2794801 tgagtccaat ggtttacccc gaatcactca aaaatgacat atactgtaaa gtaaataggt 2794861 ttattttctt aatcttctct tcattctccg aataatccaa aagacccaaa taactctcca 2794921 actcccaaaa aaaacctttc agaaaatttg atgctacagc accatttctg aaaggttcag 2794981 ttttttcttt ccttaattag tcttgcctcc gatgactttc ttagaagatt aataggataa 2795041 gctgtcgtat tatatgagac atacactgtc ctgcaaaaag gcgattacac cgccaaatgt 2795101 atatagaacg tttctctcat gaaattgttt ttttgcttct gttctttgtt gttgattttc 2795161 acaaacaaca acaatcataa taaaaggaag gggatgagat gtcaaagaga aatcaagcac 2795221 gaaaagtagg gagatttatg accatgccga atgatccgtt taaatatagt tttgacagac 2795281 ttgaagatgt ggctgatcat atcagcgacg ttctgcggtg cccgatcacc atagaggatg 2795341 ttaaccacaa gctgcttgcc tacagtacac acagcgactg cacagaccct gcccggacgt 2795401 ctaccattat tggcagaagg gtaccggaga aggtgattaa caagctgtgg aaagacggga 2795461 caattcctgc tctcttaaaa acggaccagc cgatcagagt caagcaaatc gatgaagtcg 2795521 ggctgagcaa tcgcgtcgct atttcgattt ggaaaaacaa gcaagtactt ggcttcatat 2795581 gggcgcttga gatccaaaaa acattgtccg atgaagatct gctgacattg caaatggcag 2795641 caaaagcagt gaaaaacaag cttctcaaac ttcaaatcag aaaaacgaaa aatgaagaac 2795701 gcagccaaga atttttctgg aaaatgctga ccggacacat ccatcaggag gatgatatgg 2795761 cggatgggtt ccataagctt ggaatggccg ctccttcaga gttttccgtt atgatcatcc 2795821 gcataaatgg cgagctgact gaaaaaatcg aacagcagct gcaatattta caggaaacga 2795881 cccagcaggt ttacgtgctg ctggcgaccg tagattccaa tgaacttatt atattaacct 2795941 cacccaaaac agatcatcct tttcaagatt taaaacagtt tgctttaagt acgcaaaaac 2796001 agctgaagga gcggtataaa atagaagacg tttctatcgc ttttggcgga atatacaact 2796061 ctatttcttt tgtctcccgc tcctatcagg aagcattgtc cgtcttaaaa acgaaggaac 2796121 ggttcgctga agagaccaaa catcttttca gcttttctga gttaggcatt tatcaatact 2796181 tagatgtctt aaatgaaaaa cggaaacagg cgggccatta taattactcg ctttccaaac 2796241 tggaacaata tgaccgggat caccagtcaa atatggtaga gacgctagag cgctttattg 2796301 aagcggacag caacgtgaat accgcttcca agctgttaaa tatacacgtt aatacgttga 2796361 attaccgact caagcggatc agccagatcg ctgaaattga tttgaaaaat gtgaatcaaa 2796421 aattcaccat ctatttagat atcaaacttc ggcacatgga tttgtgaaat ttcacaaatc 2796481 catgtttttt tattttctta atcaaacaaa gaattttcca aaatatcaag ctacactaaa 2796541 aatatcacat atacaggagg agacagatat gatcataggg gttcctaaag agataaaaaa 2796601 caatgaaaac cgtgtcgcat taacacccgg gggcgtttct cagctcattt caaacggcca 2796661 ccgggtgctg gttgaaacag gcgcgggcct tggaagcgga tttgaaaatg aagcctatga 2796721 gtcagcagga gcggaaatca ttgctgatcc gaagcaggtc tgggacgccg aaatggtcat 2796781 gaaagtaaaa gaaccgctgc cggaagaata tgtttatttt cgcaaaggac ttgtgctgtt 2796841 tacgtacctt catttagcag ctgagcctga gcttgcacag gccttgaagg ataaaggagt 2796901 aactgccatc gcatatgaaa cggtcagtga aggccggaca ttgcctcttc tgacgccaat 2796961 gtcagaggtt gcgggcagaa tggcagcgca aatcggcgct caattcttag aaaagcctaa 2797021 aggcggaaaa ggcattctgc ttgccggggt gcctggcgtt tcccgcggaa aagtaacaat 2797081 tatcggagga ggcgttgtcg ggacaaacgc ggcgaaaatg gctgtcggcc tcggtgcaga 2797141 tgtgacgatc attgacttaa acgcagaccg cttgcgccag cttgatgaca tcttcggcca 2797201 tcagattaaa acgttaattt ctaatccggt caatattgct gatgctgtgg cggaagcgga 2797261 tctcctcatt tgcgcggtat taattccggg tgctaaagct ccgactcttg tcactgagga 2797321 aatggtaaaa caaatgaaac ccggttcagt tattgttgat gtagcgatcg accaaggcgg 2797381 catcgtcgaa actgtcgacc atatcacaac acatgatcag ccaacatatg aaaaacacgg 2797441 ggttgtgcat tatgctgtag cgaacatgcc aggcgcagtc cctcgtacat caacaatcgc 2797501 cctgactaac gttactgttc catacgcgct gcaaatcgcg aacaaagggg cagtaaaagc 2797561 gctcgcagac aatacggcac tgagagcggg tttaaacacc gcaaacggac acgtgaccta 2797621 tgaagctgta gcaagagatc taggctatga gtatgttcct gccgagaaag ctttacagga 2797681 tgaatcatct gtggcgggtg cttaattcac aataagcttg cagaaagatt tctgcaggct 2797741 tttttatttt ttaaaaggaa aaaagagacc atttcacgaa ttatgactat gaagttgatc 2797801 ataaaggagg attcatatgg ctgttcagca atatggcgtg ttaaaaggca tagtattaga 2797861 catgaagcgg gaaacagatg atgacagtcc tcatttccaa gtcaaaatgc tcggtgaaga 2797921 gaatacgtat tacaggtgcg ccatcaatgt gatgtccagt tctgaggaat ctgaagtatt 2797981 gtatttggct gacgatcagt ttgattcggg ctcaattacc atccttccga acatgccgta 2798041 tggatataca aggatcaatg aagcaaaccg tgaagtggca ctggattatg tgcggggcaa 2798101 tttgtttgac ccgcgggaaa tgaagccttt gcctcatgaa atcacgggac ctgataatga 2798161 tttaaatgat tttattgaaa cctatatgaa gaaagcacaa gatgagaaaa cgccggttta 2798221 tatattcggt tcaaaattcg gccctgaaca ggctgcagat aaaatattcg gctttacccc 2798281 gactaacgga atgcacaata tccatatgaa tcaagggaat gcaatggata cccgctggaa 2798341 aaaagacaac ggctcttggc atgacggggg tattctgatt cagtttgcag atcagtgggc 2798401 cgctgtgttt ttagcgtttt tatcccaatc ttggtgtacc gatgaaaacg gaaaccctgt 2798461 cagagattgt gatcataccc aaacgtctgc gtaagataga aaaagagact gcggcaagca 2798521 gtctcttttt gataagatta cacattttca acagtcttta ggctgtttgg cctcatatcg 2798581 ctccaatgcg attggatata gtccaaacaa gcttcacgcc ctttttgctc atgaacgact 2798641 gtccagccgc tcggcacatc tataaaaccc ggccataggg aatattggcc ttcttcattg 2798701 accagcacca aatatgtgcc atccgcattt tcaaaaggat ttgccattct atttctcctc 2798761 ccttatttat tcaactcttc caatttgaca gcgagaacct tgccgatttg agccagaggt 2798821 tcaggctgac ataaatcttt atgacggcag tcgatgtcga tttgttcaat ctgtccgtta 2798881 atataaggct tccacgagtc aggttcaatc gggtcaaacc attcaggaat gattgttgat 2798941 ctgaaaaaca aaacatttcc gcggaaggtt ttcggcttat aggaacctaa aatgccgaca 2799001 gaatttacat acgtattctt caaatttaaa atgaccgttt catccaggct cgcaagcgca 2799061 ctgccgtcac ggcgaagaat ctcaatcgcc gcttcaaaat ctagcggttt ttcccctaag 2799121 ctgtctggat catacccgcc taacgccaga agggcaataa gcgcttcctc atcatccggt 2799181 gcctctttta taggaaggaa gtggttcgga taggcgtcca gcatcaccaa cagggatact 2799241 tcttctcctt gattttgcag ctgggtagcc atcgcttgaa cgacattccc gcccagggac 2799301 cagcccagca gatggtacgg gccttttggc tggaccgttc ggatttgttt aatgtaatcg 2799361 gcagccatgt catcaagtgt tttcggaagc tcctcgcgct gcccgattcc ccgtgcctgc 2799421 aagccgtaga tcggataatc tgttcctata ttggtcatca aaccggcata acaccagctg 2799481 agcccccctg ccggatgaac acagaataaa ggaggcttgt ctccgcttgt tcggagcggc 2799541 agcagaacgt caagagcgct ttggcttgat cccatttcaa gtctttcagc gagcccggct 2799601 acagtaggtg cttcgaacaa gttgccgatg ctgagttcaa cgccgagcgc ttcacgaatg 2799661 cggctcatga gctgtacagc aagcaaggaa tgtccgccta aatcaaagaa acggtcatca 2799721 atgccgacac gcggcaagtg aagcacctcc ataaagaggt cacagagaat ttcttcctgc 2799781 ggcgttctcg gtcctcgtcc tgtcactgcc gctgcgaaat ccggagcggg cagcgcttta 2799841 cgatcaagct ttccattcgg tgtcagcggc aattctttca tcgtcacaaa ggcagcaggc 2799901 accatgtaat ccggcagtct ctcagcagca tatctgcgca gttccgccgt atcaaatgtt 2799961 tcttccgaag ggatgacata agctgctaac cgtttatctc ccggctgatc ctcacgaacg 2800021 atcactgccg catcttcaag ctgcggatgc tgaacaagcg cggcttcaat ttctcccaat 2800081 tcaatccgga atccccgaat tttcacttga tggtctgcac ggccgacata gtcgagagaa 2800141 ccgtcagcgc ggaggcgggc cacatcccca gtgcggtaca tccgggtgcc tggaggaccg 2800201 aacggatcag ctatgaagcg ttcagatgtt aaaccaggcc ggcctagata acctcgtgct 2800261 aaccccgctc ctgatacata cagctctccg gcaacacccg gcgggaccgg ctgcaggcgt 2800321 tcatccagca cgtatacacc aagatcggga atgccgcagc cgatcaagct gtttgcccgt 2800381 aaagctgcca tgcttcggtc taattcgata tagctcacat gcaccgtcgt ttctgtaata 2800441 ccatacatat tgataagctg cggtctattt tcagggtggc ggttgtacca atcctctaaa 2800501 cggctgagtt caagcgcttc tccgccaaaa atgacatagc gcagactgag tgcctgtccg 2800561 agatccggct gttcccgttc cgcctgcata aactgataga aagcagacgg tgtctggttc 2800621 agaacagtca ccccctcttt gacaagcagg cgcagaaacg cttctggcga tctgctgacg 2800681 tggtgaggca cgattacaag acgtccgcca tgcagcagag gaccccagat ctcccacacc 2800741 gaaaaatcaa acgcatagga atggaacatg gtccagatat cacctgagct gaaacggaac 2800801 cagtgctcgg tcgctgcaaa taaacgtgtt acattttggt gaggaatcat cacacctttt 2800861 ggaacacctg ttgagccgga tgtataaatg acatatgccg tattcaaagg ggaaagcggc 2800921 tgagtcctat ccttattttt tggattacct gcagggtacg tgtttagttt ctctgccagc 2800981 tcgggatcat ccagcacgat tttcggcacg ttttcaactg gcggaatgtg atttgcagct 2801041 ttagtgttcg tcatgataaa cgcaggctgt gcatctttta gcataaaagc aattcgatca 2801101 gccggataat ccggatcaag agggagataa gctgccccgg cctttagcac cgccaatagg 2801161 ccgacagcca tttccaacga tcggggcagt gccaatgcca caaattgctc cggcccgaca 2801221 ccttcactaa tcatcattcg ggcaagccgg tttgctcttt cattcagctc tgcatagctc 2801281 agttcctgat tttcatatac aacggcaatg gcatcaggac gtaaagcagc ctgcttctca 2801341 aattgctctg gcaaacatgc gtgcggaatc ttttcagata cactttgcca atcagtcacc 2801401 atgctgctgt gttcctctgg cgcaagaata tccagatttc cgatttgctc gtcaggatca 2801461 gactcggcag cctccaacag gcgcatcaat cggtcagcaa gagcctgagc agtttcccgt 2801521 ttgaaaagat cagtgctgta ttcaagcagt ccttccattc cgtttggtgt cccgtcagca 2801581 aggcgatctt cactaatttc cagcgtcaaa tcaaacttgg cagaaccgac actgttgatt 2801641 cgcaggctgc tctccatatc aggaagatgc agttcagcgt ccggtgtgtt ttggaacgca 2801701 agcatgattt ggaataaagg atgcgtcgca cgcgaacgag ccggattgag cacctctaca 2801761 agtctctcaa acggcagatc ctgattgtca taggcggcca gattcacttc ccgtactctg 2801821 tctagaagct cacgaaagct tgggtcaccg gacgtatcag ttctgagcac caatgtatta 2801881 atgaacagcc ctacaagatc gcccagcgca tcatcattcc gtcccgcgat cggactgccg 2801941 atcggaatgt cggtgcccgc cccgagcctt gtcaataaag cggcgagacc ggattgaagc 2802001 accataaaca ggctcaccct atttgcgcga gccagctcct gcaatcgctt gtgaaactcg 2802061 ggctcaatac gaaaatgaat cgtatctcca tcatgactcg gctcagccgg acgtgaataa 2802121 tcggttggca gttcaagctg atcaggcagg tttttcaagg tttctttcca gaaagcaagc 2802181 tgtccggcaa tcaagctatt tggatcatcc tcgtttccaa gcagttcttg ctgccaaagc 2802241 gcatagtctg catactgcac agcaagaggc gcccattcgg gagatcgtcc gtggcagcga 2802301 gccgcataag ctgtcccaag gtctctggtc agcggtgtta aggaccagcc gtccccgaca 2802361 atatgatgga cgagaagaag cagcacgtac tcgtcaggac cgatcacaaa aagctcggca 2802421 cgaaaagcag gttcagctgc aagatcaaag ctgtagcgta cagcttcggc aagccgatca 2802481 gaaagctcct tctcagcaat ttcagtaaca tgtaactcgg gacaggctcg atcggcatct 2802541 aaaatatgct gataggatgt cccctgtgat tcagggaaga tcgtccgaag actttcatga 2802601 cggcagacga ggtcataaag tgccgctttc agcaatcctt gatccaactc acctgacaaa 2802661 cggacagcaa ccggaatatt ataagtagga ctcggtcctt ccagacaatg caggaaccat 2802721 agccggcgct gggcaaatga gagcgggatc ttttcaggcc gctcagctct ctgcaaagcg 2802781 ggacatgcac tctgcgccaa atcaagatgg gcagcgagtc cggctactgt cggttcgtca 2802841 aagagcttgg cgataccaag ttcggctccc attacctcgc gaatgcggct catcagacgg 2802901 gctgcaagaa gagaatggcc cccaagctcg aagaaactgt catcgatacc gacgcgtgcc 2802961 aaaccgagaa cctctgcaaa caagtcacac aatatctctt cctgaggagt ccgcggggcc 2803021 cgatcactga cagatgtgct gaagtctggt gccggcagtg ctttccggtc aagcttgcca 2803081 ttaggtgtta acggcagctc gtccatctcc acaaacgccg acggtaccat ataatcagga 2803141 agactagccc ccatataacg acgaagctct gcagtatcaa tagcagcatc agcgactaca 2803201 taagccgcca atcgtttgtc tcccggctga tcttcccgta cgacaaccgc ggcctgttca 2803261 atgtgcgggt gattggcaag cacggcatca atttctccaa gttcaattcg gaatccgcga 2803321 attttgattt gatgatccgc ccgcccgata taatccaaag acccatcggc gcgccagcgg 2803381 gcctggtctc cggtccgata catccgagtt cccggcggtc cgtatggatc tgcaacgaag 2803441 cgctccgccg ttaaatcagg acgatggaaa taacctctgg ccaagccggt tcctgcaata 2803501 taaagctctc cgacaacgcc cggcggcacc ggctgcaatc cattatcaag cacatacacc 2803561 tgcgtgttcc aaatcggttt cccaatcgga ggaacgccct tcagcccttc ttcaagaaaa 2803621 gctgcggcag accaaatcgt tgtttcagtg ggaccgtata agttcgtgac tgaacaatga 2803681 aggtcttgaa gttcctgcaa aagaccgctc ggcagcgcct cgcctcctac aagcactcta 2803741 agcccccgaa gtttctcagg ttcactcgtt accaaagcgt gccacagtgt cggtgtcgcc 2803801 tgcataatgt taatatcgaa attttcaatc atttgagcta atgcctgcgg ctcacggatc 2803861 gtttctttct ttgcgatcac gatttgcgct ccgctaatca gcggaagata taactccaat 2803921 gctgaaatat caaaagcgac agtcgtcaca gccaacagcc tgtcttcttc tcctagagaa 2803981 aatgcctcct gcatagacag cagaaaattg cttaagcttt tctgtgtcac aacgactccc 2804041 ttcggtcttc ctgttgatcc tgaggtatag atgatatacg caggatggtc aagcgaaacc 2804101 gatacatcct gattttccgg cgaatagcgt tttataatct cctgtgtaac agcctgatca 2804161 agcacaagct caggtacagc caggtcatca ggcagactgg ctgctatttc ctcagtcgtt 2804221 atgatgcatg aaggtttcgc atcctccagc atgtaagaaa tgcggtcggc tggaaactcc 2804281 ggatcaaggg ggagatacgc cgcaccagtc ttgagcacac caagcattga agccaccatc 2804341 tcaggggaac gcggcagcgc caaagcgaca aattgctccg gaccaatccc tttttcgatc 2804401 aacagacgcg cgaggcggtt tgcctcttca ttgagctttc gatagttgac ttgaatgtca 2804461 tcacacatga gagcgatacg ttctggcgta agaactgcct gcttttcgaa catgtcctga 2804521 aggctgacca gcttctcgga ttttgccgtc tcattccatt tagaaatgac tttttctttc 2804581 tcctctggca acagaagctc catttgccca atcagcatgt cctctccggc agaagccgtt 2804641 tgcagcagct gcaaaatacg ctgctgatga agcttaatat cagactcact gtatacctcg 2804701 ggattcgcat caacatcaat tcgcagcccg ctgccgtctg ttctgtcata tacattgatt 2804761 gatagatcat caacaggacc ggctgaaaga ttatgcgttg tgccccggac gccggcaaag 2804821 tcgagaccgt aatcaaacgg cataagattg atttgagggc caaataatct atgattttct 2804881 cctatcaatt tcagatcgcg cctaagctct tcatggcgat acttatgatg tcgccgaata 2804941 ctgcggattt cccgggaaat ttgctgaatc agttcagaaa agctcatcga agagcttacc 2805001 gtcagccgga gcgggagaag gttcatcacc atagccggta cattcagtga cgcggaccct 2805061 atccgaccca tcatgggcag gccgagcaca acatcctcag agccggtcat acggtgcaca 2805121 taaacagctg acaccgcaat catgacttca tgccagcttc ctgagaaata gcgcgccgct 2805181 tcttttaacg cgtttacatc agacggaggc agatatgccg tatgacgaag aaaactgtta 2805241 gatgttcttg gcgcccgatc agccaagctc acaacttcag gtgcatctgc aaaacggtcc 2805301 agccagaatt gacgatcctt ctcatactgc tctgatccgc gataatctgt atcctcctcc 2805361 aaaatggcct ggagagaccc aaaggaacgg cttttagctg tttgtccttt tataagggca 2805421 gtatatgtac ttgccacacg ctgggctatc agggaaaaac cgaagccgtc gatcgctata 2805481 tggtgaatgc gctgatacca aaagaaacga tcaggcccgg caataaacag agcttcattg 2805541 aacaaagggg cataccctaa atcaaccggc tttgctaaat cagctttcat ccagtttaat 2805601 gctgtttttt ccggatcagg ctcagagctg acgtcaatga cgtgcagctg tacatccgga 2805661 gacgggttta tcatctgcca aggcccgtcc atattttcac cgaagcggac atgcagcgat 2805721 tccgcttcct tgatcacgtg ccgcaaagct tcttcaaaaa gagcaatatt gactggtcca 2805781 ttgatttcta tatattccgc tgtattgtag attggattgt ccggatcaag ctgctgagca 2805841 aaccatatgc cagtttgcgc cccggtcaaa gaatattgaa gatcttttgt atcaggcatc 2805901 cgtttgttta ccctcctttt ataaataatc cgcgtttggc agcacttgct ggctgcgagt 2805961 tgtgagcaat ttctgccatt cttcgatcgt tgggcgttca gccaattcca cgaaagtcac 2806021 ctctgcccct tcacggcgcc attgttccac caatgtcatg atccttaccg aatcaagacc 2806081 acgatcgagc aaatcctctt gatctgtgat gtcttccggt gtttcttgta gaagctcagc 2806141 aatttgttta cggatattct cacatgtaaa cacgttcttt ttgccagtgt ttgctgacgt 2806201 tttttgaacg tctgccggcg cattctgcag ctgatcaaga agactgtcag tcatcacggt 2806261 aaacgcacag cgtccagccg catattccag cgccatttga tgtttttcta atgaaaaatc 2806321 agcaactgca tctcccacaa aaaaggcttt aatatcctcc ataaatgctt cacatgctgt 2806381 aacaagacag ccgatatggg cgtaaattcc tgtaatgatc agctgatcgc gtccctcttt 2806441 gcgcatcatt tcaagcagat tcgttctctt aaacgcgctg tatctccatt ttgtcagcac 2806501 aagatcatca tcctctggtg ccagctcggt tataattttc tcctcataag gaccgctgtt 2806561 taatcccggg ccccaaaagt ctgtcagcag cgcacggtca tccggatttt ggcttcccgg 2806621 ctgtgcggta tagacaacag gaatcccaag ctgaacacat tgattcttca gctttcgtat 2806681 attcgctgaa agctctgtta ccggagacgc tcccgctgtg aaagcatcaa caaaatagtt 2806741 ttgcatatcg tgtattaaca agacagcccg attcggatca ggcacccatg atactttgtt 2806801 ttgcggcata tcagatgctg tcggcatttg atacggctga atggcaggta tagccatatg 2806861 aacacttcct ctcaaattgt tgttttattt tttaaatcct gcaagaagct tctcggaaat 2806921 ggcttcacgg agcgcttttt tgctgacttt tcctactcct gtctgcggga aggattcgac 2806981 aaattcaact cgatcaggga ttttatatgc cgccagtccg cgctctctca aaaatgcttt 2807041 aagctctgcg gcttttgggg cttcatcccg gggaataatg aacacacaag atctttcgcc 2807101 aagaaattga tcaggcatgg agaccattgc cgcatcatgg acagccggat gcgccagcag 2807161 atgattttct acctcttcag ccgcaacctt ttctcctcca cggttaattt gatccttcgc 2807221 ccggccttca acgacaatat agccgtctcg tgtcagcctg acgatatcac ccgtacggta 2807281 aaaaccgtcc tcagtaaatg aagcggcgtt atgctcttct gccttatagt aacctcgaat 2807341 tgtatacggc ccccgcgtca gcagatggcc tgtttcacca ggttttacgt cgcgatcatg 2807401 atcatcccaa acacgcattt catcatatgg agacatcggt tttccttggg tgttgacaat 2807461 gatctcctca ggatcatcca atctcgtata attgacgaga ccctctgcca ttccgaacac 2807521 ctgctgcagc gtgcagccga aaacagcttt taccctgcgc gcggcttcag cactaaactt 2807581 ggcaccgccg acctgcagca cttgaaggct ggataaatca tcacggcgtg aggatgccgc 2807641 atccatccat accatcgcaa gaggcggaac aagagcggtt atcgtgacct tttcccgttc 2807701 aattaaagga aatgcgtcat ctggacttgg agaaggagat aataccactc ttcctccagc 2807761 gtataatacg ccgagaacgc cgggtgagct cagcggataa ttgtgtgcca tcggcagcgc 2807821 ggccaagtac accgtgctgt ggtcgagcca gcagacctcc acactccgct tcaggctgta 2807881 tatgtagtca tcgtgggtcc tcggaatcag tttcgatagc ccggtgctcc cgccagaaag 2807941 ctggaggaac gccacatccg atgatttgac ttcaggcagt tttacaggtt ctgcatgcaa 2808001 atcctccagc ggtaaaaatt cctctgcctc acctgcgaca atgatgtttt tcaaagtcgg 2808061 cagcttgctt tgaacctgtc tggcaagcga acggtagtca aaaccggaat aagcgtcggg 2808121 aatgatatat gcagccgctt cagcaaactc gcaaaaatat gtaatttcac tgcttcgatg 2808181 agaaggcagt gcgaagactg gaagcgcccc cagacggaaa agcgcgaaaa tgacttcaaa 2808241 aaactctttg atatttggca actgcaccac aacacgatcc atctgttgaa tgccgagctt 2808301 ttgaaatccg gcagccaggc gatcagccct tgtgtcaagc tctcgatagc tccaatgggt 2808361 gtttccgcat gtaatggcaa tgcgatcacc atatttggct gcccggtccc ttaacaaatc 2808421 tccaaacgtc tcaccggccc agcagccgtt ctttcgatag gtctcagcta actcatcagg 2808481 ccaaggcgta aatcctttca gcatgttgta tccctccagc aattcattct gttcatatgt 2808541 gatccacgcc cattgcccgc agcattgtcc gaaactttgc ggacgtctcc tgaagctcgt 2808601 cctcaggctt tgaaccggcc acaacaccag ctccagcata caggcggagt gagcgttctt 2808661 ctgcttctgc acaacggatg gtcacgatcc attctccgtc accggcatcg tcacaccatc 2808721 cgaccatgcc ggtaaagaaa ccgcggtcaa atggttcaat gctgagaatc gcttctcttg 2808781 caagatcagt cggtgttccg cagacggctg gcgtcgggtg gagcgccgcc gccaattcaa 2808841 gtgcggttac agacgggtcg gaaagctctc ccttaatcac gctggacagg tgccacatcg 2808901 tttccgtttt gatcagtgaa ggcttctccg gaacctccag cgtccggcag aaaggtctca 2808961 gcgctgccgc aaccgcgtca gcgacaaccg cgtgctcatg aagatccttt gcggaagaaa 2809021 gcaattcagc tgcccggcgc tggtcttcaa caggatcatt actgcgcggt cttgagccgg 2809081 ctaatgggtt ggaaacgacc tgtgttccca tccttgaaac gagaagctcc ggacttgctc 2809141 cgagcaatgt tctgcgggga gacgtttcct cctgactgga cacgtctgcg gcaaacgtgt 2809201 agccatgcga gttatgctga gccagatggc gaagcaattc atccgtctga atcggttcag 2809261 gcgatgtcaa atgcagcgat ctggacagga cgattttgct gagtgttcca tcggcaatgc 2809321 gtgccagccc ttgttcaaca ccatttttat aatcctcagg ttcaggaaca ggctttatgt 2809381 ggtatgtatg cccagcctgc tgttcctttt cctcatgatc aaattgaagc ggtcctgacc 2809441 agcgcacttc ttcaggtaca acgagccgcg ctgcttttac ttgatcaaaa ggaacggccc 2809501 cgacaacaag cggccggctt tgccctgatt gttttgcctg acgtaacgcc tctgcaattc 2809561 ggccagaaag ggtttccatt tggttttgcc cgtctgcctc cggtacaatt tcacatatgc 2809621 ctttcgctaa cagtacacga tgaggagacg ctaagaaaaa ggcgcccggc tgatattcat 2809681 gaagcaaatg ctccgctttt gtttctgtta taacgttttg atccaacatt ctcatgaacc 2809741 tcctttaaat tcagttacac gcctaaggtc gcgccgccat ctacgcataa attatgcatc 2809801 gtaatatgcc ctgcctggcc agaaaccaaa aagagcaccg catccgcaat atccgaaggc 2809861 ttggctagtt ttttgagcgg gatccctgtt ttaaatgtct caagtgatcc ttttatgact 2809921 tgctccgctc cattctcgtc ggcccataat gaccactgca tgtctgtttc cgttgatccg 2809981 ggagatacaa tgttgcagcg aatattgtat tctgcaagct caaggccaag gcatttcgta 2810041 aacatcacag ccgcagcctt tgaagacgca tatgccgcca tagatgttct tggtacaccg 2810101 gcagcattcg atccgactgt tacaatcgaa cccgatcttc ggtccatcat atatttgctg 2810161 actgaacgcg aggcgttaaa tacgccagtc gaattcactg agaacgtcgc ctcccattcc 2810221 tcatcgctaa gcgaatggat cagtcccggg cgaaggacac ccgctacatt cactaaaata 2810281 tcaatcggcc ccatttcacg ttcgatgcgc gccgtgatct cgtcaatcgc cgcgctgtct 2810341 ctcacatccg caggaaaagc ttctgcatgg cggccttctg ctttgaggct gctcacaacc 2810401 ttttccagct tttcaggatt ataatcaact gccgcaatat gtgcgccttg actggcaagc 2810461 gtccgcgcaa cagcttcgcc tattccttgg gcagcccctg ttataaaagc aatttttccc 2810521 tctataccct ttgcattcat atcatcaatt cctttcttcg ctctaaatgc caaacagaca 2810581 tccagcgaaa aagactgctg cgccttgaaa aacgcaatct attgataatg attatcatta 2810641 tcaattataa aaataatcat atccaaatgt catgtgacag tcaaatataa tttcagtgac 2810701 aaatattttt ttaaaggcaa ggctgagtat gtctcagccc attgatagat gcggtccgtc 2810761 agggtgaagc gcaaaacgca gcgccctgct gaccaaaaca ggaagaactg aaatatgtcc 2810821 ttctcctgaa aactcgcaaa attctgcccg tataccttgt tcagataaaa cggccagccg 2810881 ctcataaagc tcccttgcat tatcattcat ccggctttta tgatgctgct ctaattctcc 2810941 tgcggcaagc aggatattga taggctgatt gtttttcttg gtgagagaga cgaaatggtc 2811001 cgttttcttg agaataaacg gtttattcca atgaatggac ggacttcccg cgatatacgt 2811061 ttgaaacgca tcgggctttg ttagcagcac ctgcagcacg aaaagccctc cgagcgaatg 2811121 gccaaagatt gtttgtcttt ttttatcaat ctggtaatct cgttctatct ccggttttaa 2811181 atcctcttca ataaatctga aaaagccctc cgctccgcca tgctccggcc attctctgcc 2811241 gtcgggcctt tccggcagct tcgattgggc tgttggcatt gtaaaatccc ggtggcgtgc 2811301 tgaggagaac ggctccgctg tctcatagcc aatgccgacg atcactgcag ggatcacccc 2811361 ggttttttcg ggtcggcgtc cctgtattcg aacggcttcc gtcatcgttc cgaagacaga 2811421 attggcatcc agcagataaa tcacaggata accagcgggt ggcggcggcg tactaggttt 2811481 cgagataaaa atgtgatagg tacggttttc attgcgtgaa gacatcatac gcacttccgt 2811541 accaggaatc gtaaatgcgt ttgatgtccc gccatttgtc cggtctgttg tttgttcttt 2811601 catgcagtac gacattcctc tccttaaact aaaccgcaat gtatgataat gattttcact 2811661 atcaactaga cacctcaaat aataggtttt cttccaaaga aagtcaactt tttcccgaat 2811721 aaaaaaggca ccttgatcaa ataaggtacc tgcagactat caatatggaa gtaaaaacct 2811781 aataaagatg cgtattgtcc tatttgaaat agaaccttaa tcccatgtaa acctttgatt 2811841 ttgccaaggg tcgcctctca tgtgatagcc attccgctcc caaaagccag ggtgattttc 2811901 tttcgtaaat tggatgccgc gcagccactt ggcgcttttc caaaaataca gatgcggaaa 2811961 tacaccccgc agcggaaagc cgtgttcagg ggttaaaggt tcgccattat gcgcataagc 2812021 cagaagggaa gtttccgcta agaaatcatc aagcggcaga ttggtcgtcc agccctcttc 2812081 agcatgtaaa atgacgtagc ccgcttcttc ttttacaccc gctttttccg ctatatcaca 2812141 agcccgcacg ccttgccaca cattatcaag ccttgaccat cccgtgacgc aatgaatgtc 2812201 gtttttcgat tcataccgtg gaaaggcttt gacatcttca aagcttagca gcatcggatg 2812261 gtcaaccaaa ccgtatactt gaagattcca tttcgtcata tcttcgtaat atgggacatc 2812321 tccggtatga agcacaggaa atgaagtggt gacgttttga tttggcggca ctcttccaga 2812381 ttgatcggac tgtcttgttt ttccgaaata catatgggcc tcctttttgt taacctaatt 2812441 taaaatcatg ttgacaatct ttttgttctt tattactcta tgattgtgta tgtcaaccta 2812501 agggggaaca acgatgaaac aacgtaaact tcgtgcggga gatatggcgc tgattggcat 2812561 gttcgccgca cttatggctg tcggggccaa cattacatca gtagcaccct ttttacaagt 2812621 agccggcatt ccgctttcga tgcagccgtt tttctgtctc ttggcagctt tgcttcttgg 2812681 cagcaaacgg gcagcgattg ccatgattgt atatgcactt gtgggattgg ccggagcgcc 2812741 tgtgtttgct caattttcag caggcttcgc accgtttgca gggaaaagcg gcgggtttat 2812801 tatctcatac attccggcag catttgcagc gggatggttt ttagaacgaa acattcagcc 2812861 aagtaaaatt cgatttctca ttgcttcact tatcggaacg gcgatcatgt atctcatcgg 2812921 cactacctat atgtatcttg cactgaagct gtggattcat acgccagtga gctacggcac 2812981 ggcttggggc tttatgattt ggtttatggt aaaagataca gcgctggctg tgatactgtc 2813041 gtttatcgca ccagcaatct accgctctat tcataaagca accggcttta acagaaatca 2813101 catatcatct acgtaaaaac cgttctattg gacggttttt ttatcataac gagaaaaggc 2813161 tccccagtaa aggggagcct ttttcctata aaacaagcgc tgcaatccag ccaaagatga 2813221 caagcggaat attataaaat ataaatgtcg gcacacaagt atcccaaatg tggtgatgct 2813281 ggccgtccgc actcaaacct gaagtcggcc caagcgtact gtcactggca ggtgaaccgg 2813341 catcgccaag cgcagcagca gccccgataa tcgcaatcgt tgccatcggg ctgaatccaa 2813401 gctgcatgca tagaggcacg aaaatggttg tgataacagg aatggtcgca aaagaagatc 2813461 cgatccccat tgtaattaat aagccgacaa tgagcatcag caatgcgccc aaggactgac 2813521 tgtgtccgat aaaaccagct gacgttttga ccagtgactc gacatctccg gttttcgtca 2813581 atacgtttga aaatccggct gcaacaagca tgacaaagcc gataaaggcc attaaaacca 2813641 ttccatcagt aatcagtgag tccgcttcat cacgcttcat cacaccgctg acaaacagaa 2813701 caatcagacc agcgagcgcc cccataatca ttccttctac tcccaaagtc tgagataagt 2813761 aaagctggac gccgagtgac acaacaatgg ctagaaccgc gataccaata ctttttctcg 2813821 tatatggcga tgcttctgca cctgaaatgt cttttgtttc atattgtttc ggtttacggt 2813881 atacgatcac tgataaaata aggccgacaa ccatacctgc aactggaata atcagtgcgt 2813941 acggaatatc agcaagcgga acgtttaacc cggcatccgc catattgtcc ttcagcatgc 2814001 cttggaagat ttggccgaaa ccgaccggaa gcaaaatata aggagccgtt aagccaaatg 2814061 taattacaca cgcgatcaga cggcggtcca tttcaagttc attaaagatt ttcaaaagcg 2814121 gcggaatcag caccgggata aacgcgatgt gaaccggaac gacgttttgc gaaaaacaag 2814181 atacaattaa aataatcagc acaatcagca ccttagacag tgcttttttt cgagaatctt 2814241 ctttatttcc gattaattta acggaggctt ccaccattgc gtccggaaga cccgttttcg 2814301 tcaaagcggc ggcaaacgcg ccaagcatgg catagctaac tgcaacggtg gcatttccgc 2814361 cgagaccgtc tgtgaaagct ttaaccgttt cgccaagacc gagcccgcct gttaacccgc 2814421 cggccaaggc gcctataatt aatgcgataa caatattgac acgcagcagg cttaatacaa 2814481 gcataagcag gactgcgatg acgactgcat tcatgatgat acccctccaa aaatccttta 2814541 gtttgctaat gtagtagata aataaagtac gaacgtatcg tatcataacc gatccacttt 2814601 agtcaactaa agatttcgga agaaaaaatc cctgccgcat catacagcag ggatttttca 2814661 ttactcgttt ttatcttctt ccaatgtaaa tcgctccgca agtgtagcca gtgttcttgc 2814721 cataacgcca gtagccccgg ccggtccgaa gcaggttgct ttattggcag tcgctgtgcc 2814781 tgcaatatca aggtgaaccc aaggtgttga ctcagcgaat tcaccaagaa acgttcctgc 2814841 cataatcgca tgtccctcgc gtcccggtga attgctgaga tccgccattt ggctgctttt 2814901 cacgcgtttt ttatccttct ctgttatcgg cagctgccag atcgcctcgc cgcactcttg 2814961 tgcagcatca gctacctgct ggtaaaagct ttgatcattt gtcattgcac cggttgtttc 2815021 tgttcctaat gccacaacga cgccgccggt aagcgtagct acatcgacaa gaactgatgc 2815081 gccatgctgt ttcgcgtatg taatgccatc tgcaagcact agccttcctt cagcatccgt 2815141 attaaggatt tctattgttt ttccgcttaa agatacgatc acgtcatccg gcttcatggc 2815201 cccgccggag atcatattat cggttgatgg aataacgcac agcacgtttt gttcaggacg 2815261 aagctctccg atcgtttcca tagccccgag aaccgcagct gctcctccca tatctgattt 2815321 catgccaaca attccagatt tcgttttaat ggagtagccg cctgtgtcaa aggtaattcc 2815381 tttcccgact agtccgacga cgtcttccca ttcctttttg ccctgatatt tcaacacaat 2815441 cattttcggc ggttcggtgg agccttggtt taccgcaagt attccgccca taccgagctc 2815501 ttccatctct gatttctcca atatctcaca ctcaaaatca tatttcgccg caagctcttc 2815561 agcatacgaa gcgaggtcag tcgctgtcag catgtttccc ggcatattca caagcgttct 2815621 agccgaattt gtcccttgtc cgtatgcctg gccgacgcga agccctgcct gcacttcctg 2815681 tgtatcttca tctgttacaa catacacggc ttcaatttgt ttgtcaggct catttgattt 2815741 atgcttataa tcctgcacct cataggaagc aagcaggcag ctctcagcta aagcatgagc 2815801 ggcatcggct ggaggcacgt cttccgaaat aaacgtatca agcagaacag cagtttcttg 2815861 ttttcgatct ttatgaatgg cttgaaaaac atgagcaaaa cgttccttcg cctgttcaaa 2815921 cgaataattt gcttctctcc ccaggccaac gaaataaatc cgtttcatac ccgcagaaga 2815981 tggagggaat acttttgata cttgattcgg tttcgcagag acatcaccct cttttaaaag 2816041 ctgtgtcaga tggccttcga gcatttcatc aatttccaac gcttttcctg tcagctggct 2816101 tttttgaaaa agcccgacaa caagggtttc tgtatgctct gattgttgaa ccgcataaaa 2816161 catgaggctt acactcctaa cgtaatgggt atttgtaatg aacaatggta taataggaaa 2816221 aacattcttt ccactatact tattttaaca aacaacagtc taagacttgc ttttttcttt 2816281 tgaaacacga aggatttttc aaatagaaag gatgtcgccg atggaacttt taacgaattt 2816341 tcctttatta tcaagcctgg ccgcaattat ttttgctcag gtcatcaaag tgcccataca 2816401 gtttatcgtg tccagaaaac tggactggtc gctggtcaca agcacaggcg gcatgcctag 2816461 ctctcactcc gcagcggtca ctgcgctttc tacaggcgta gccttggagc atggattaga 2816521 ctcctcactc tttgcggttt ccgccatttt cgccgtcata accatgtttg acgcaactgg 2816581 cgtcagacgt cacgccggtg agcaggcaac agtcattaat aagcttgtta ttgattttaa 2816641 ccgtttcgta aatgaagcga aggacttccc taaggctgca gagaaagaaa agcaaaaaaa 2816701 gctgaaagag cttctcggac atcagccgat cgaagtcttt ttcggaggat taacaggtat 2816761 tttactgaca ttggtactcg cttacttttt catgtaaaaa aaacgctcct gctttcgctg 2816821 gagcgtttta ttctttcacc gttttatatt gatttctgaa cacttgcaaa gattttgttt 2816881 cattgagctt ctcaagctca tcctcggtaa tctttcccgt tcccttttta atcacatata 2816941 catcaagggt ttttttgccc cattcattgt atacatcttt gactgtctca aagtacagat 2817001 caaggcggtt tcccttaata gctgatcctg tgtcggccac aactccgaga ccgtagttcg 2817061 gaatgaataa aattgttccg atcgggaaaa cggacgggtc agcagcaacc gtggaatata 2817121 aatcccgttt cactttcaca cctgaatatg taagcccgta taatggatca ccgggatttt 2817181 tgcccgtcga ctcagctcct gctgtgtagc ctgttgctgt tactctttgg actggatatt 2817241 catcccaatc aaatgcctct tctaacggtt ttgttttatc ctcagccgcg gacgtggttt 2817301 gtgtttgttt ctgctgcaat gcttttaatc tcagtcctgc atgcttcaag tgcttttcct 2817361 gatgttcctg cacccatttt gacaagtcct tcgcttcaat tcctgacact gataaaaatg 2817421 tcgtgccaaa tgcaagcaga aataaacagg tcatcagcaa acgtctgatc atattcaaca 2817481 tcattcacct ctcctccgaa tcattgttcc caagtggaga gagcattatt caaaatggtg 2817541 aatgagctga acgcataaaa aaagctttct ttagaagaaa gcggcattta aaacatttga 2817601 tatcctcttt ttctaagcat gttgatcgct ataccggaca cgatggcgcc ggccaaaccg 2817661 ctgactaaaa tcagcacatc agcagccgct aatgataaga cacgatgaaa caggctggca 2817721 aaggattctc ccggcgactg gacatagctg atcagctttt ctttgctgat aatgaaaagg 2817781 catacaattg gataaatcac agccataatc caagacattc tcagcagcat gtttaataag 2817841 aaaccgattc caaaaaacaa gacaaaaaac aaaacaattg agatgattac gactggcaga 2817901 ctaatcaacc tattccaccc ccctgcgttg tttttagtgt aacgcggggg ctgaaataaa 2817961 gtcaacggct ggaaaaagaa tgactgtctt ttcctgtccc ctggcaagac ggacaagtct 2818021 ctgaaccgcc gagaatcaat tgaaaatatc ctttccctga acaaaatggg catgcatgtg 2818081 aagcggttgt cgttgcagtt ttcatctaat catcaccctt tttcttaatt ttctgataat 2818141 ataccatatc aagctgtcaa caataaagtc agatcatgtg acaaatcttt tgatgtaagc 2818201 ggaaacatac ttgttttcct ctcgttctct ttttattttg gcgtttttta ataaagaaaa 2818261 cccgcttccg cgggttttta gaaaaacttg aacttgcctt ttttcaatgt cagtccgagt 2818321 ccgccaatca taaacagtga gcggttatca atgacttttt tcataaacga agcgggcgtg 2818381 cctttcagct ttctgccata aacaacccca accgcgttat gctcgccaag agaagccact 2818441 gttcccttaa tgtccggctt gaattcctca agctctccgc ctttaataag cctgccaagg 2818501 tttttagcga ccgttatgcc ctgctgcatt gcaatttgcg cagtcggcgg atacgggcgc 2818561 tctgtatctt cattcataaa cagcgagctg tcgccgagaa taaagacatt gtcatgtccc 2818621 ggggcgcgga gatcagggtt gactttgact cggccgcgca tattctcaaa accggcttcc 2818681 tccacaatcg gatggccgcg gacacctgcc gcccatacaa cggtttgcga tttgatctgc 2818741 tctggttctt catctttttt gccgactctg actccttctg gtgtacattc ttgtacagcc 2818801 gttccgatct tgaactcaac tccgttttcc tcaagataat gtacggcgta atcaacaagt 2818861 tccggatcaa agcccggcaa aacggtcggc gctgcttcca cacaaatgat gcggacaagg 2818921 cttctgtcaa cgtcatattc cttacagagc tccggcacgc gagcagccag ttcgccaaga 2818981 aattcaattc ccgtaaatcc ggcaccgcca acaacgatcg ttaacctgtc cggccgtttt 2819041 tccgcttccg tattgtaagt cgcaaactgc agctcaatat gttcccgcag caggcgcgac 2819101 gtgttgatgt tggcaatcgg aaacgcatat tcttttaagc ctttaatgcc gaacgtttca 2819161 ggcacggcgc cgagcccgat gactaaataa tcgtactgca attctccatt cgcaagcaca 2819221 acttttttct catcaatttt gattgccttt acggtatcct gtacaaaatt cacccgtgac 2819281 tggttgatta catcttttat ctgataacgg cagcggtcat gatggagcgt acccgcgctc 2819341 gcttcatgca tccatgtcgt ttcataatga taattgtgtt tatttacaag cgtaatgtca 2819401 gcatcattcg gcccgacata cttcgtcagc cttgtcaccg tcatcaatcc gccatatcct 2819461 gcacctaaaa tcacgatttt gggcttattc aatgccatca catccacctt ctcttttttt 2819521 gcttttgtta gacccataat aaaatcatca tttgtgttag cttcagctta ttggcgggat 2819581 tttatgaaat atattgaaaa gttttttgtg aagtccttac ccgtagcact attatcatgt 2819641 ttatccggct ggcccaagaa acattcagaa aaagatcatt tcatttggtt attatcgtag 2819701 cggcctgcgg aaatattttc aagaacggat gggcacgtta gatccttacg attttttctg 2819761 ctgactcgtc aatttgaacg gcaatatggt ataattaata acaattttca tttaggaggc 2819821 aattttcgta tgcgagagga tacaaaggtt tatgatatta caattatagg cgggggaccg 2819881 gtcggcttat tcaccgcttt ttacggcggg atgagacagg caagcgtcaa aattatcgaa 2819941 agcctgcctc agctcggcgg acagcttagc gccctatacc ctgagaagta tatatatgat 2820001 gtagcgggat tcccgaaaat ccgcgcgcaa gagcttatca ataacctaaa agagcaaatg 2820061 gcgaaattcg accaaaccat ttgtctggag caagcggttg aatctgttga gaaacaagcg 2820121 gacggcgtgt ttaagcttgt aacaaatgaa gaaacccact actctaaaac ggtcatcata 2820181 actgcaggaa acggcgcatt caaaccgaga aagctggaac ttgaaaatgc cgagcagtat 2820241 gaaggcaaaa acctccatta cttcgttgat gatctgcaaa aattcgccgg cagacgcgtt 2820301 gcgatccttg gcggtggaga ttccgcggtt gactgggcgc ttatgcttga gccaatcgca 2820361 aaagaagtat cgatcattca ccgccgcgac aagttccgag cgcacgagca cagtgtggaa 2820421 aaccttcatg cgtcgaaggt taatgtcctg acaccattcg tccctgcgga gctgatcggc 2820481 gaagacaaaa tcgaacagct agtgcttgaa gaagtgaaag gcgaccgcaa agagatttta 2820541 gaaattgatg acttaatcgt caactacggt ttcgtttcat ctcttggacc gatcaaaaac 2820601 tggggcctgg acatcgagaa aaattccatt gtcgtgaaat caacaatgga aacaaatatc 2820661 gaaggcttct ttgcagcagg tgacatttgt acatacgaag gaaaagtcaa cctgattgcc 2820721 agcggcttcg gcgaggcacc gacagcagtg aacaacgcca aggcttacat ggacccgaaa 2820781 gcccgcgtac agcctcttca ctcaacaagt ctttttgaaa ataaataata aaaaaaggag 2820841 cttgtgtctg cgacacagct ccttttttat ttgaagatat ttatataatt caatgcagtt 2820901 cctacaacca gcgcaatcac aagggctgcg actacccaga tcattgccat aataatgcgg 2820961 tcctgaatct tttgggactt cggtgttttt tcttcgtttt gggccatctt attcgctcct 2821021 ttcccatgtc catgccataa agaaagcctg gtgctgaacg accaagcttt gctgaacgta 2821081 tatcattcgc gttttgatcc gctctctaag accattcgtt aaaactatga tacctaaact 2821141 caccctgcat gacaagcttc ggcacttgca ccacacctgc cagcaaatca taatgtttga 2821201 catcctaaat aaaacagagt acattatata aggcgaacat ttcatatatt atacttttaa 2821261 atattcgttt ttaggagtga aaaccatgga aaacgtattt gattacgaag atattcagct 2821321 aattcctgca aaatgcattg tgaatagccg ttcagaatgt gatacatccg tacgtttagg 2821381 cggacataca tttaaattgc ccgtcgtccc tgccaatatg cagacgatta tagatgaaaa 2821441 actagcgatt tcattagccg aaaatggcta cttttatgtg atgcaccgat ttgagcctga 2821501 gacacgaatt gattttatta aagatatgaa cgcacgcggg ttattctctt ctatcagcgt 2821561 gggcgtcaaa gatgaggagt atgaatttgt ccgccagctg gcagaagaaa atctgactcc 2821621 tgaatacgtg acaattgaca ttgctcacgg gcactcaaat gctgtcattg aaatgatcca 2821681 gcaccttaaa aaacatttgc cggacagctt tgttattgct ggcaatgtcg gaacgccgga 2821741 agcggtcaga gagcttgaaa atgcgggagc ggatgccact aaagtcggca tcggaccggg 2821801 aaaagtatgt attacgaaaa tcaaaacagg cttcggcaca ggcggctggc aattagcagc 2821861 gctgcgctgg tgtgccaagg ctgccagcaa accgattatc gcggatggcg gcatccgcac 2821921 ccatggcgac atcgcaaaat caatccgatt cggcgcaacg atggtcatga tcggttcact 2821981 atttgccgga cacgaagaat cgccaggcca aacgatcgaa aaagacggaa agctttacaa 2822041 ggagtacttc ggctcagcct ctgaattcca aaaaggcgaa aagaaaaatg tcgaaggcaa 2822101 aaaaatgcac gtggcgcata aaggctcaat caaggataca ctgattgaaa tggagcagga 2822161 tcttcaatct tctatttctt atgcaggcgg aacaaagctt aacgccatcc gcaatgtgga 2822221 ttatgtgatt gtgaagaatt ccatttttaa tggggataaa tattaatcat aaaaaaacgc 2822281 caagtcagcg gttctccgct tgagttggcg ttttctgcta cttcttcagc aaagtaagct 2822341 tatatttgct ttttgagttt atcttccatc agttctgcca tttgttttgc atttggattt 2822401 tcttcatttt gcaactgttc aatgacgttc atataatccg tttcatttcg gttctggctt 2822461 aatttatatg ccgcttgaat gtcttccacc ttaatcttaa atccaacaat acctttcaat 2822521 tcactttcta agagttttgg agaaagctta tcccataaca caggattgtc acgatgtttt 2822581 tcgtatttct ccaacatgat tgttaattct tctgctaatt catctttctc taacatactt 2822641 gcttttccat acatgtggac agcctgataa ttccacgtcg gaacattttc gcgcgaatac 2822701 caggaagaag aaatataagc gtgcggtccc tgaaacatca caagcacatc ttcacaggct 2822761 tcaaacgttc tccactgagg atttccataa gcgaaatgcc ccgtaatata gtaatgatcg 2822821 tcttttttat tgaatcctaa cggcaaatgt gtggcaattg gttttccttg ttctgttgtg 2822881 acaaccgtac caaaggagtt ttcttgtaca aaattccaaa tttcttcagc atttgtgact 2822941 ttaaaatatt ttggaatata catcatcatc cacccttcga aaaatattat atgagtgttt 2823001 tagccatgat taaatccgtt tgttcttcat cacccatata aaatgagtgg gcgccggtct 2823061 gaacaaaccc cattttctta taaaaggcaa tggcattttc atttttttcc cacacaccta 2823121 gccaaatgtt ctttttatta cgttccagcg caatttctat cgctttattc agcagatgtt 2823181 tgccaagccc atgtttttga aagctgttct ttatataaat tctctcgatt tcaagtgatt 2823241 cagcacccat ttcttcagac tgagcatcat cgatattgac ctttacatat ccagcgattt 2823301 catgatcaaa gtaaataaaa aagaattgcg aagacatatt agataactct ttttccagct 2823361 gctcagtgtt aaatgcgctt tctaaatagg ctttcatatt ttcaggtgag ttctgttctt 2823421 taaaagtgtc attgaatgtt tcaatactca attgttgaag tgtttgtaaa tcttcccggc 2823481 tgcatttttt catttttaca ctcattgttc ggattcagcc cctttattta aaattcaatt 2823541 gtcttgtgtc ccttttatat atttaaacac ggaacacata ctgaccttgt taccattcca 2823601 aaaatcttct tcatcaccaa ctccctatcg tgattttgtt gtaaatgcaa taaaatatac 2823661 tccgcattaa atatatcgta actttgctgt atttacaaca aaaatcaaac aacaaagcag 2823721 cgtttctctt gccgaagttc ccggaactct ctgcatcatt tccccataat aaaaacgcct 2823781 cccttaacga tgatttatcg ctaagaaaag cgtcagtaat agttgctatc cgtttttagt 2823841 gcttagcact cttcaggctt gcctgcattc gttgctgttc tgaacgaaga accgcagccg 2823901 catgaagcga tggcgtttgg attgtcgatg gtgaagccgc cgccgagcat ggattgttta 2823961 taatcaatca cggtgccgtt catgatgtca aggctttctt tgtcaactag aacagtgatg 2824021 ccgtgctgat caaacacact gtctgattca ctcttttcat gctcaaagcc catgccgtaa 2824081 gaaagtccgc tgcagccgcc gcctttgacg cctacacgca gaaacgcgtt ttcttcttca 2824141 tgctctttca tcatatcttt tatatgcaaa gctgctgctt ctgtaattgt taccgggttg 2824201 ctcatcatta tgaacctcct tttaaaaacc ggttgctgtc ttttattata aacatgatcg 2824261 ttccaattct caaacaaggt gttttacaag aaatagacac cctcacaaac ggtttcagcc 2824321 ggccctgtca tcattacatg gccgttatct ttccagttta tcaccaaatc cccgcctgct 2824381 aaatgcaccg tgatgtcttg atttcgcttt gatacgccgt ttaatacaga tgcgactgcc 2824441 gctgcacatg ctcctgtccc gcatgcctga gtaatccctg atccccgttc ccagacgcgg 2824501 aaatgcaatt cttgttcatt cacggtttca acgaattcca cattgatgcc ttccggaaat 2824561 ctcggatctt tctcaatcac cggccccagt gtcgttaagg gtgcctgttc aatgtctgcg 2824621 atcggaaaaa cgatatgcgg atttcccatt gaaacggcag tgcctgttag ttctacttca 2824681 ccaaatgcca tcgtttcatt gattgtgtgc tcttccccgc cgtcaagcat aggaagctcg 2824741 gattttgtca agcgcggttc gcccatatcg acagtgacca cattcacttt tccgttttcg 2824801 acttgaacct ccgctttcac aagcccggag agagtttcaa tcagaaaaga tgtttcctca 2824861 accagcttat gctcatatgc gtattttgcg acgcagcgca ggccgttgcc gcagtttttc 2824921 ccttcagacc cgtcattatt aaaaatccgc attttaacag gcgcttggtc tgatgggcat 2824981 atcaggatca ttccgtcgga tccgatccct gtataaacag aagaaacctg aattgcaatc 2825041 tctgacagtt tttcttctgg aagctgttct tcaaattgat tcacataaat ataactgttt 2825101 cccaggccgt gcattttggt aaatcgaaat gagttcatag gtgcctccaa ctttttttct 2825161 ttttcttagt ataaaagcta ttataagcgg acacaataca attatccccc gtttttcata 2825221 cataaaagct ccttgcactg acgcaaggag cttttatcgt ttatataaac atgccggcaa 2825281 tggctgcgct gagcagattg gctaatgttc ctgcaagaac agccttcagg ccgagacgtg 2825341 cgatatctga acggcggctg ggcgctaaac cgccaagcgt accaagcata atcgcaattg 2825401 atgaaaaatt ggcgaatccg cataacgcga aactgataat ggtagcagtt ttcttagaaa 2825461 actcgccgat gtgcgaaccg aagttagaat aagcgacaaa ctcattcagc accaatttct 2825521 ggccgatata gcttcccgcc tgcaatgctt catgccaagg cacgccaatc aaaaaggcga 2825581 taggagaaaa cacatagccg agaatggatt ctaatgttac gccttttaaa ccgaacaagc 2825641 cgaaagcccc gccgagaata ccgtttacta cagcgattaa cgcaacaaac gcaagcagca 2825701 tcgccccaac atttaacgca atttgcagtc ctgttgacgc tccctttgca gctgcgtcaa 2825761 tgacattggc tgcgccttcg ccttcatcca ttttgaaatc gctttttacg gtttgcgttt 2825821 tttccgtttc gggtataatc aatttaccaa agactagtcc agctggagca gccataaagc 2825881 tggccgccag caagtactca atcggaatac cgagaagcgc gtacccaaac aaggtagatc 2825941 ccgcaactgc cgatagaccg ctcgtcataa tcgtaaacaa ctcagagcgc gtcagcccgg 2826001 caatcagggg tttgatcact aacggagatt ctgattgtcc tacaaaaata ttggcagcag 2826061 ccgccagaga ttccgttttg cttgttccaa ggagcttcga caatccgccg ccaatgacac 2826121 ggaaaacgag ctgcatgatt ttcaaatgat ataaaactgc aatcagtgct gagaagaaaa 2826181 tgataacggg cagtacactt aatgcaaatg ccggactgtc tccgaccttt agaagcggtc 2826241 caaaaataaa actgatgcct tcattcgcat agtcaatcag aagctgtaca cggcttgaaa 2826301 accataaaaa aacagcgcgt cccgcttccc atttcaacac gatgtatcca aacgccacct 2826361 gtgtgcataa accaacgatg acggttctta tcttaatatt gcttttcttt tctgaaaata 2826421 aaaacgcgat agcaatgatc gcaactgcgc ccagcagccc ccacagaaca ttcatgaata 2826481 ctcgtacacc tcttaaattt tatttaaaaa aatatctttt atacgataac aataatattt 2826541 tttgatgtct acacattttt ttagttcttt tgtacggcaa aataaaaaag ggcctgtcca 2826601 ggcccttttc tttaaaacat tggattttct tcaataaagg tatatatatt ctcaacaagc 2826661 tcagcaggcg tttcacccat gacgacttct ccgtttacca gagcgaaaag cgattccata 2826721 catgtcccgc agtagcttaa gcagccatat tcaaggacat caaggttggg atccttctcc 2826781 aaaatcgccc gggcttcctg agagccgtga gccagattgc tgacacaaaa ttcaatcatt 2826841 ggattcatgc ggtttcacct cacatatgtc cattatcgcg aatttttcac tattcgtcaa 2826901 agacaacgga tgattcaaaa tttattatcg taacatatta tttctcaaat aacgttttac 2826961 taatttgtgt tttcaggcta aattgtaggt tattttgaaa ctattattgt gattttagat 2827021 caaattcgat ataattctag atgttatttt acatagttcg tattttcttc aatgtatcta 2827081 tcatactctt cggattaaag gggaattcaa atgaaaaaat tggtcttgat cggcggaggt 2827141 tacgggaaca tgcgcgttct tcatcgctta ttgccaaacc agctgcctga tgatgtttca 2827201 atcacgttaa ttgacagaaa tccttatcac tgcttgaaaa cagaatatta tgcccttgcc 2827261 gcaggcacaa tttctgacca tcatatcaga gtgtcattcc cagagcaccc tcgcctggat 2827321 gtccaatacg gtgatatcac atcaattgat attgtacaaa aacaagtgct gttccaagat 2827381 cgtgaaccga tttcttacga tgacgccata atcgggctcg gctgtgagga taaatatcac 2827441 aacgtgccgg gagcgcctga attcacctac agtattcaaa ccatcgatca gtcccgcgaa 2827501 acctaccaaa agctgaataa tctgagcgct aatgccaccg tcgccattgt cggagcgggc 2827561 ttaagcggcg ttgagcttgc aagtgaattg agagaaagcc gtgatgacct gaacattatt 2827621 ttgttcgacc gcggtaatct cattttatca agctttcccg agcgtttaag caaatatgtg 2827681 caaaaatggt tcgaagagca cggtgtccgc attattaaca gggcaaatat cacaaaagta 2827741 gaagaaggcg ttgtgtataa ccacgatgat ccgatttctg cagacgccat cgtgtggaca 2827801 gccggcatcc agccaaacaa agtcgtcaga gacttagatg tggagaagga cgcacaaggg 2827861 cgtattgtat taacgcctca tcataatctt ccaggtgatg aacatctgta cgttgtcggc 2827921 gattgcgcca gtcttcctca tgcaccgagc gcccagctgg cagaggctca agcagagcag 2827981 attgtccaaa tcttgcaaaa acgctggaat ggagaagccc tgcctgaatc aatgccgcag 2828041 tttaagctga aaggcgtcct cggttcactc ggaaaaaaag ccggcttcgg gcttgttgct 2828101 gaccgtccgc tgatcggccg tgttccgcgt atgctgaaat ccggcttgct gtggatgtat 2828161 aaacaccata acggttaatg atagagaaga accgctgatc aagtcagcgg ttttctgtat 2828221 acccatgctt ctccatttcc tcataaacgt cttttaattt tggattgcct tcaccgacaa 2828281 ttttgtcttc tacaagcaca agcggataaa aatactcgtc atttctgatt ttttccgcaa 2828341 gctctttcgc atgttcattg tcaggcggct catgaatatc gatgtactgc atctcaaaag 2828401 gctgatttgg atattttctt ttcagcgcag cctcaagcca ctcgtatgta tccttggctg 2828461 tcggcatatt tacacagctc gcacaaacgt tttctgcccc gtacacgctt agcatgactg 2828521 gtttcatcac ttgtagacgc ccccttctcc tatgtaagtc ctttctttta agtatacaga 2828581 gcctaagggc gtttttatag aaaaaaaccg tttttgtgtt gaagtctgaa tgtgctataa 2828641 tagggaaagc aactttgcaa accaaacaat agatttttat tgttacactg aatataatgg 2828701 ttttatgacg acgaaaggag cgaatgtcat gactgaagtt gaaatgaaag aacaggtgca 2828761 ggaagtactg gacaaacttc gtccgttttt acttcgtgac ggcggtgact gtgagcttgt 2828821 agacgtagat gaaggtatcg ttaagcttcg tcttctaggc gcatgcggca gctgcccaag 2828881 ttcaacaatt acgttgaaag ccggaattga gcgcgctctt cttgaagaag tgccgggtgt 2828941 cgttgaagta gaacaagtct tttaataaag cagccaggct gatatttgat cagcctggct 2829001 tttttattag agatgttgat caaaccatga gctgatataa ttcaggcgct tgatccgctg 2829061 tcttgggtgt ccggtgcgtg ataaattgtg cgatgcattc ggaaaacgga caagcttggt 2829121 ttccttgccc atttttttca gagcgataaa cagctgctcc gcctgctcga tcgggcatcg 2829181 gtcatcccgc tcgccatgca gtatcaaaag cggtgtctcc acgtttgctg cgtattttaa 2829241 aggagaccgg tcccagagct tttctgtgtc ctcaaacatg tcatgctcaa gctgccagtc 2829301 tgtaaagaaa tagccgatat cactgacgcc gtgaaagctg atccaatttg atatcgagcg 2829361 ctgggtaacg gcagctttaa agcggttcgt ctgcccgacg atccagttgg tcataaaacc 2829421 tccgtagctt ccgcccgtga caccgagccg cttaggatca atatgcggat ctcgtttgat 2829481 agcctcatcc acagcctgca tcacatcgtc ataatccttt cccccataat ctcctctgac 2829541 cgcattcaca aattcctgcc cgtagccgtg gcttcctctc ggattgatat aaacgaccgc 2829601 gtatcctttc gccgccagca cctgaaactc atgaaaatat gtatgtccgt acatcatatg 2829661 cggaccgccg tgtatgttaa gaataagtgg atatgttgtc tcaccttcca tttgtgcagg 2829721 cctcatcagc cagccgttca ccatcacgcc gtcttctgta gcatattgaa tctcttcagg 2829781 tattgatatc gtatgctccc tgacaaactt gtcattcgcg ccagtcagct gtttctcttc 2829841 ctgtccaagc gggatactgt aaagctcact cggtctgtcc ggctttgtca cactggcaat 2829901 aaagtgctgt tcatcaggtg aaagagaaaa gctattgatg tactcttttt ccagacgaat 2829961 cggatacaca aggccttcaa tcgaaatata atagatgccc gtactgcctt gatctgtgcc 2830021 gatgacataa aacccttggc tgtcctttgt ccaaatcggg cgctgttcag caccaccgat 2830081 caatgaatct ccaatcagcg catccgctaa atgaacgtcc agcatctcag taagacatgt 2830141 gaggcggcct tgttcgatat catagagcca cgcctttgag agcgtagcat tcttatattc 2830201 cttttcattt ccaagcaaag caagatacct tccgtctggt gaaaatgagc ttgatccgaa 2830261 tgagccgcga tgaggtgtaa cctgcttaag atctccagac tccagtgaca ttatgtaaac 2830321 atcatgcggc ttgctggcat catctgtttc agttaaatta gctgagaaaa caagccattt 2830381 gccgtcagga gaaaaagcag gatcaccatg atcagctttg tgacttgtca gctctttcat 2830441 ctcacccgac tttacgctga caagcacaag ctgggcatac gcacctctcg tcagcccttt 2830501 gccgtcccgt ttgtaggaga ggccttgcac ttcaacaggt tcatagctgt cctgctctgt 2830561 tttttctcgg tcatcaatgc tttccccctc tcccaaactg acagtgacca gaatcgattc 2830621 accgtccggg gaccatagcg gctttgacac gccatatggg atatcagtca gttttcttgc 2830681 ttctccgcct tcagtgctca tgatataaag ctgtgccgca tcgccttctc gatcagaaat 2830741 aaaggcaagc gtgcgcccgt ccggagacca tcttgggtcg gtgcttcgct tttctccatg 2830801 tgtccaagga acagatcctc ccgttttcgt ttcatagatc catatatttg atgtatacga 2830861 atctttctct tgatttactt gtgattttac atatgcggca cgggtaccgt ctggggcgta 2830921 ttgaggatcg gtcacagaga caatcgctgt gatgtcgtct gcggttatca gctttttcat 2830981 attcatctcc tcctttttac atgtatttcg tttttctaaa taaaaactcc tttatctcca 2831041 gcaaaaaaaa gcgccctccg ctgacgctga ggaacgcttg gcatgatcta tacacttttt 2831101 acttgatata aaggatttcg ctctattata cttccctctt tcggaacggt caaagcgtct 2831161 acttcacaat gagggaaatg aagcgcgagc tgttctttta gctcttctcc ctttcctttt 2831221 tcggtcatga cgagaatcgt tgggcctgct ccgctgagag ccgttccata tgcgcccttc 2831281 atctcggcga cgtgctctac ttttgacagc tcaggcacaa gcatcgcccg gtacggctga 2831341 tggaacatat ccttcttcat gattttcccg acaagcggcc aatccttgga catgatcgca 2831401 gcaatgagga tattgctgac agcacttgct tttacggcat cggcatatgg aaactccttc 2831461 ggaagcacgt ctctcgcgtc tcttgtcagc acttcataaa aaggaatgac aacgactacg 2831521 tcaatgtcag cattcgggac gcggatcatt tgggtctcgt catcctcatg caggccgatc 2831581 acaagtccgc cgacgagaga agcgccagca ttgtccgggt gtccttcttc tagactcgct 2831641 aaatgcagct tgtccgcttc agacagcttt aagccgcata attcatcagc cagttcaatg 2831701 gccgctacaa tcgctgcggc gctgctgcca aggccgcgtg caagcgggat gtcgctccac 2831761 accttcacat ggacaggagg catttctttt ccgtacaaat ctgcggtccg tttagccact 2831821 tggtagatca ggttatctgt acccgccgga attccggcga ctgtttctgt ttcagcctca 2831881 aaagaccatt tgtcgctttc aaagacggtc agcttcaaat atctgctgag cgccattccg 2831941 actgaatcaa agccggggcc taggttagct gtgcttccgg gaacagtgac agagaacagc 2832001 atgtcggctt cgttcataca cgggccgctc cttttacata ttcaaggatg ctgtcttcat 2832061 cagtcggcaa tgtgacaggc ttgatttctg aaatgtcgac cgctgtgttc ggatctttca 2832121 gtccgtttcc tgttaacaca gctacgacct tgctgccttt cggaatttct ccggatttca 2832181 cctgtttcag cactcctgcg atagacgcgc aagaacctgg ttctgcaaac acgccttcta 2832241 cacgggcgat cagctgatat gcgtgaagga tttcatcatc agtgacttcg tcaattttcc 2832301 cattggattc ctcggctgcc tttacagctt tgtcccagct tgccgggttt ccgatacgaa 2832361 tggctgtcgc tattgtttcc ggattttcaa tcacttcatt gcgcacgatt gccgccgcac 2832421 cctcagcttc aaagccgcgc attttcggaa ggcctgtgcc gtttttctca tgatattcct 2832481 tgaagccctt ccagtacgca gtgatgtttc cagcatttcc gaccgggatc gctaaaacat 2832541 caggcgcttc ccccagctgt tcgcacactt cgaaggcagc agttttttgg ccttcaatgc 2832601 ggtaagggtt gactgagttg acaagggcaa tcggtgattt ctcacagatg gaacggacaa 2832661 ttttaagcgc atcgtcaaag tttccgtcaa ttgcgataat ctcggctccg tacatgacag 2832721 cttgagcgag ttttccaaat gcaatttttc cgttcgggat gatgacaatg catttcatgt 2832781 tagcacgggc tgcatatgct gccgcagcag cggaagtgtt acctgttgac gcgcacataa 2832841 tcgtgtcatt gccttcttct tttgcctttg ccacagccat aaccattccg cgatctttaa 2832901 atgatcccgt aggattgacg ccttccgttt tgacatgaag ctcaattccg agctgctcag 2832961 acagcttcgg caggtgaata agaggtgtgt ttccttcatg taaagttagc gccggtgttt 2833021 gatctgttac aggtaaaaat tctttatatt gatggataag tcctttccac attagctcca 2833081 accgttccct tctacacgat atgtgctttt gacttcttga acgacttcca aatcatttag 2833141 gttttgcagg atatcactga aatcagcttc tgatgtatga tgtgtgacaa ttacgatttc 2833201 agctaactca tcatggcctt taattggcag ctgaaggatt ttttcaaagc tcacgccccg 2833261 ctctgagaac acagatgtaa ttttcgagaa tgaaccaacc tcatctttta catgaattct 2833321 taaaaactgc tgtgcataaa tgtcagacgg cgatttcatg tttttctcat attgcggtcc 2833381 gacaaagctg ttgccggtta cacctaggcg catatttttc atgacagcga cgaggtcaga 2833441 aacaacggat gtcgctgtcg gcatgcttcc ggctcccggc ccgtagaaca tcgtctcacc 2833501 gacagcctcg ccgtatacat aaacagcgtt aaactcatta tgaacagcag aaagcggatg 2833561 atggtcagga agcagtgtcg gctgtacgct gacctcgatt ttgctgccgt cacgctgagc 2833621 aatcccgatc agcttcattg tatagccgag gcgtttgctg aagctgatgt cctcgtctgt 2833681 aatttgggag atccccttta ctttgacgtc ttccagatcc acgttcatcg agaagccgag 2833741 gcgcgccaat atcgccattt tccgtgcggc gtcaagccct tccacgtcag aagtcggatc 2833801 agcttcggca aaaccgagat cctgcgcttc cttgagcact tcctcgtatg ggcttttctc 2833861 tttgatcatt ttggttaaga taaagtttgt tgtgccgttc acaattccca tcatttttgt 2833921 aattcgatct gatgagaggc cttcctctaa cgtgcgcaga atcggaatcc cgccggcaac 2833981 actggcttca aagtagatat cgcatccatt ttccttcgct tcggcaagca gctcggagcc 2834041 gtacacagcc attaagtcct tgtttgctgt gacaacatgc tttttcgatc tcagcgcgtc 2834101 gaccaaatat tgttttgtct gttcaacgcc gccgatcacc tcgatgacga catcaacatc 2834161 tggatcatca atgacatcat acacttctgt cgtgagcact tccttcggca aatctacttc 2834221 tctctttttc tctaaatctt ttacaagcac tttttttatc gtaaccggac agccgacctg 2834281 atgcataagc ttatcctgat ggtcttgaat aattttaacg acaccgcttc cgacggtacc 2834341 taaacctaaa agccctacac gaatcgcttt caaaaaaact ccacctttct tttgattgtc 2834401 ctcttggaaa agacaattgt taactcaaca cagacatata agttacaaac attatataag 2834461 cccgctcctg ttttgacaag acatcattag gctgaatttt gcgaatgtaa acgcttaacg 2834521 cattgatatg acaagattct ttattttcta attatttttg tcagattttc tcctcacctt 2834581 gagctgcctt tgccgagcca gctgacgcgt ggaacaaaca gcttctgcgc ccgcatattc 2834641 atgaattcct gcgctgtatt gagaaattgt tcataacgcc cacagtcatt aagaatgaag 2834701 tcaagctgtt cttcaaaata atgcttttct gattctgatg acatgtaata gctttctacg 2834761 atttcaaaat aatgaagcgg gaaaagcaga cggctgtata aaaggcgttt cgaaaatgaa 2834821 gacagcggtg tgacttgctc gtattcctgt aaaaagagaa agccctgctg attaaaatct 2834881 tgtctgtgat gcaaaaacgt atgcctcata tattcagcca aatcacggga agcgtggtca 2834941 aacacccaat ccgccggaat cctgatcaat gattccggtg accatgtatg cctttccatc 2835001 cgctgatggc atatcgttcc tgaatcagcg gcttggggct tgtcatccag ctcagtgtcc 2835061 actaaatatt gtatcgcgtt ttctgacagt cctaaataat atggaaatga ttcgatcatt 2835121 tttttatcga atggctcatg cggaggggtc tgaacctttc tctgccaaaa tgcttccagc 2835181 tgatcaattc gttttcccca cagatccttc cactggccga ttcttccggc cgccttcacc 2835241 tcatatggat atcctcggcc ttttcggtga aattccgcaa gctccgctcc aatggagaac 2835301 gccctgtttg aataaggggg ggccgccttc agcagagcgt acgtttttcc ctcatgttca 2835361 aatgtcagtt caccttcttt tgtaaagata aaaaccgaaa cgtatgggtc actttgttct 2835421 tgtaaatact gactcatgta ataaagctcc gccagctctg tttctgagaa ttgggaaacg 2835481 gggacaatca gaaagtatga attaggcgtc tgaaagcatt gatatgtgtg ctggtacatg 2835541 gaaagctgcc tgatgtgaat gccgtatttt tcttttattg tacctttcac catgatcacc 2835601 tgcctgttga attagggctc atcacatcgt agtcatacac agccggaatt atgaatacat 2835661 attttaatcc gaagaaggcg caagaaaaag tcgtaaactt ctcaagcatt ttgtataaac 2835721 tagtaaaaaa gattgggtga agctgatgtc agaaaacgaa caattcagtc agatggaagc 2835781 taaagcaaga gcacggatga aggagcgcgg cgttgaggta tcagacattg ccgagcttgt 2835841 cttttttctg cagaaaaaat atcatccgga tttaaccatt gatgaatgca cgctgaacgt 2835901 caatcgtgtt ctcgcaaaac gcgaggtgca aaacgcgatt ttaacgggca ttgaattgga 2835961 tgttcttgct gagcagaaaa aattgtctga accgctgcaa acgatgctgg aaatagatga 2836021 aagcctatat ggagtagatg aagttctggc attttccatt gtgaacattt acggatcgat 2836081 cgggtttacg aactacggtt acatcgacaa agaaaaaccc ggaatcctta aacgattgaa 2836141 tgataaatca accggtgaat gccatacctt tttagatgac atcgtcggag cgatttccgc 2836201 cgcggcttca agcagacttg ctcaccgcgc gcggcataca gaataagggc acccttttag 2836261 ggcgcccttt tttcaaatgt atggaatcca ttcagtcaga gagtcaatgg cgtgagtcgg 2836321 tttttccata tcgtctgtca tatgttctct tttcgttacg cctgtgtgaa cgagcagcgt 2836381 atccataccc gcgttaatgc cggccataat atcagtggcg tagttgtcgc cgaccatgag 2836441 tgtttcagac acatctgtgc cgagaacgcg catcgcctgc tccataataa ttgattccgg 2836501 cttgccgata aatacaggct gtacacctgt agatacggtt aacaccgatg tcagtgagcc 2836561 gtttcccggc aggagccctc tttcagtcgg aatcgcaata tctccgttag tggaaataaa 2836621 gcgggcgcca tttctgattg ccaggcagcc aacagcaaat ttttcgtatg taatggaacg 2836681 gtcgatgcca acaacgacaa aatccgcgtt ttctccgcca aatgtcaggc cgttttcttc 2836741 aatcgcctgg cggattcctt cctccccaat cacatacaca gacgcgtctt ttttctgctg 2836801 tgcaatgtgc tgggcagttg ccatgctggt cgtgaagacc tgctcttctg ttgccggaat 2836861 atcaaaagac acgagcttgt ccgctacctg cttcggtgtg cgcgaagagt tgtttgtcac 2836921 gaaaagataa ggaacgccgc gatctttcag cgttctgaca aattcacacg cctcctcgat 2836981 tttttccgtg ccattgtaca tcgttccgtc taaatcaatt aaataccctt tatatgtttt 2837041 catatccaac actcctgtgg ctttccagtt gttatttaaa cgcggaaaca ggtcctagct 2837101 ctgtttccaa atagcttctg atccgtttcg ggaagtcctg aagagctgtt tgatgcgcct 2837161 tgatcagcct gtaaagctcg ccgctgtcag cgagcagata ctgttgaacc aacgttttgc 2837221 ggtaggcgat caattttttg agctcatcac cctctttttc cgtgacaact ttctcatcaa 2837281 caagtatatc cataatgtcg tcatagctgc ccgggtcccg cataataaag ccgtcaatca 2837341 tgtcattgcc tgtatccaaa atgcattcga ttaacagatg gcctatacgc tgaagtgcca 2837401 attccccgat ttcagactgc cagtctgttt gtgagtcaaa tagcgccagc tggtgctcga 2837461 agaaccctag tgttttttcg attttgcttc tgtcaacaaa atacatgaca gcatcccctt 2837521 tgtgtatatt tattttctga tccgtttcaa gacaaaatac gcacagccga aattgcagta 2837581 ttcgtaaata tattcatcta atgtgctgat tttcgtttcg aaggttgcct tttgattctg 2837641 gtcgtcaaag aagcccttga gccttaactg accgtatccc cagtctccca caatataatc 2837701 gtatttattt aatatatcgg agtagcgggc tttaaaagcc tcttcgttga agccgtcttt 2837761 gaaattgtgc accaattcaa attcggcatt ttgaataaga atcatgatct cacctctttt 2837821 ttcactcatt cctatcataa ttcattgccc cgtccccatc aattgctaaa gaataaatca 2837881 tgcgatttgg ctaccctaca catgaggagg gattgataaa tgaaacgaac cgctgtcagc 2837941 ctctgcctgc tgaccggact attatccggg tgcggaggcg caggattgga taatgcccaa 2838001 aatgtccgga atcagacgca gaatcaaacc aaacccattc atgtgtcgga ccgcaacgag 2838061 gcttttaaca ggcataatga gaacgaacaa tttggctatg tccgctatca aaaagaacaa 2838121 tttgacggag aacagcagaa aacgccggtg atgaaccggg aagaaaccgc tcacatgata 2838181 tcaagtttaa cggttcagct cccccatatt caagatgctg cgacattggt gactgaccga 2838241 gaagcgcttg tcgtatacaa aaccgattct aaaaaccggg agctgaccgc cgatcaggtg 2838301 aaaaaaacag cggcttctgt gataccgcga tactatcacg tgtatatttc cgataatcca 2838361 aaccatatgc aatccgtcga aaattacagc aatctcggct ctggttcaag ggatattaga 2838421 gagatcatgt cggggacgat tcaagaaatg aaaacctccc cgcaaggaag ccctgtctca 2838481 gagaatgaaa atgccaatgg agaaacgcgt caggacatga aaatcgatag gaatgacaaa 2838541 aacgccagat gatctggcgt tttggcatta tgcttgtgct tgacgctttt tagatgcttc 2838601 gtttacttgt tcatccgcat ggtaagagga acggacaagc ggaccggctt cacaatggct 2838661 gaagcctttt tgcatcgcga tttcttttaa ttctgcaaat tcatcaggat ggtagtattt 2838721 ttggactttc aagtgtttct tcgtcggctg cagatattgg ccgattgcca taatatccac 2838781 gttgttcgcc aagaggtcgt ccattacttc aataatctct tcttttgttt cgccgagtcc 2838841 gatcatgata cttgattttg tcggaatgtc aggctgcatt tccttcgcac ggcgcaaaaa 2838901 ttccaatgaa cggtcgtacg tcgcacgcgc gcggactctt ggcgtcaggc ggcgaaccgt 2838961 ttcgatattg tgattcagga tgtctgggcg tgtatccatc aaggttttta ggttatcgta 2839021 gtttccgccc atatcagacg gcagcacctc aattgttgtg aacgggcttt ttctgcggat 2839081 cgcacggaca gtttccgcga aaatgcctgc cccgccatct ttctgatcgt cacgcgcaac 2839141 agccgtaatg accgcgtgtt tcaaattcat aagcgcgact gaatccgcta cgcgttccgg 2839201 ctcttgcaga tcaagctcag ttggaaggcc tgttttgaca gcacagaaac ggcatgctct 2839261 tgtacaaaca gaacctaaaa tcataaatgt cgctgtacgt ctgaccgccc agcattcatg 2839321 aatattcgga cactttgctt cttcgcatac ggtatgcagg ttgttttccc gcatgagttt 2839381 tttgagccct gtatagtttt catttgtatt taatttaatt ttaagccatt cgggctttct 2839441 gaggtgttcg tctttctttg ccaattccca tcatctccaa tatccaatat actcaatttc 2839501 tgacacgaaa cattctgaaa acgagaaagg tgcaggtttt agttctgcaa caaaaataat 2839561 gtttttctaa ctaaagaaag tcttttcttt agacacttta acataggaaa aatttctcga 2839621 caagggaaga tgattactga catttttaag ccgggttgcc gcaaactatg tgtattcaat 2839681 atgaaaggag attattttgt gaaagttttg ttatccgctc ttcttctcct tttgtttgca 2839741 tttgagcctt ctgcgtctgg aaaaaaactt tcagatccag tgctgtcgaa acggatggaa 2839801 ttatatcata aaatcgaagc tgtgacgcag atcccttggt atgcgctcgc cgctgttgat 2839861 caatacgaag aaaacgtgcg gagcaaccgg aaagatctgc ctgaaaaggc gggaatcatc 2839921 agcatctata tacccgatga tatctggagc gggcctgaaa acccgaatcc gaaagacgat 2839981 gcgccgttaa gcattaaagt gtttgacgga atcggaatgg atggcgatgg agacgggaaa 2840041 gccgaggtca gcaacgatga agatatcttg tatacgttca gccaatactt actgtcgtat 2840101 ggcacagatg aagacaacat ccggatcggg ctttggaatt attaccggcg tgatcagaca 2840161 gtggggatta tatctgaatt catgaagctg tttaaagcct acggccatat tgatctgggc 2840221 gagcatgcat tcccgcttcc gatcagaacc gattacagct accgaagcac gtggggagat 2840281 gcccgcggct tcggtggaag gcggattcat gaaggtacgg atatctttgc ccattacggc 2840341 cttcctgtca aatccacatg ttacggcgta gttgaaatga agggctggaa ccgcttcgga 2840401 ggatggagaa tcggcatcag ggacattaac aatacgtatc attattttgc ccatctcaat 2840461 gggtttgcca aagggattaa aacaggacaa atcgttgagc ctggccaagt gatcggatca 2840521 gtcggcagct ccggatacgg cccgccggga accgccggga agttcccgcc gcatctgcac 2840581 tatggcatgt acaaagataa cggaagaacc gaatggtcat ttgatccata cccgcatttg 2840641 agggcgtggg agcgatatga ataccaaaaa aagaagtaac aaaaagccgc ctcttcaaca 2840701 ggcggcttat ttgctgcttt tttctttttt tgaatcggca ccgttttctt tgctgctcgg 2840761 aagctggaca gaaggcgtga cacccgagcc gccgcttcca ttataaaact gcggcacttc 2840821 gccctgcact gctttaatcg atacaggaac attatttgtg acgacagcgg ttttgctggc 2840881 aaatggaatg atgaccttca ctttaatttc gacaaagatg ctgatatcaa taagtgcgtt 2840941 atttatgcca tacggcttga ttttggtttt gacatctgta aaagcgtcac cgattaaatt 2841001 gaaccggacc gggattttcg gcccgaggtt tccaagaagg ctgttgccgg ttacctgtcc 2841061 cagcggaatg ttgatcataa tgttttcact ggcgccgctg tgtccggtat gggtttccat 2841121 ctctttcaaa tgagcctgaa gctgctttgt cacttttgtt ttcacactgt ttacaacctg 2841181 tgtattaaaa tcgattgtcg ttaagtttcc gttttcatca gaattcattt gaaacatatc 2841241 tttcatattt tcactgtcag acatatagtc ctcaatcgaa tcctggatca cctctgtcgc 2841301 tatacgcttc gtttccatct cgccgatgtc cattaaaaca ggtttgatcg agccattgat 2841361 catccaaagg ctgaccgttg ttgacaggat aaaaaagaca acggacagga gcatcacgta 2841421 acggaaaggc aaaggtcctc tcttgcgaaa agggccgcga tatcttggca agaaaatccc 2841481 cccttacata tcacaatgta tgcttgtaag aggggacata gtaatagccg gggccaattt 2841541 attttatttc atcattttta aaagcgcttc tctgccgctc atgccgactt tgatgccaag 2841601 atcttccgca gcgtacgtga cggattctaa aggtgcgtct aacagctggt caatggtgcg 2841661 gacaccaact gcgcgtcccg ccacgatgcc gcgctccttt aatttttcat tcagcagcgc 2841721 cacatcaagc gcgccgcaca taatgtatcc gtgatcattg gcgacggcca taaaattcgt 2841781 tttgggaagc tttactgtca cagctgtaaa aggctgtcct tctatcatga tcggtgtcag 2841841 gtttaccacg tcaaccactc ccttcattca tcactttatg atgaagggca cagcttgttg 2841901 tgggctgact gccttattgt gcaagcttcc aagcaagcag atcccgcaaa aattccggca 2841961 taaaatattc tttttctgca gcgtcgcgaa tcaacggaaa cagtttgccg agcgtaaaca 2842021 tatcaagcac cgcaacggag tattgtttat gtttttcaat atcttccccg ttcagtgtga 2842081 tccgagtgac gtgggtgatc ccgtcatcga gccgtttcgt ttctacctca acgccggcat 2842141 acaccatttt ccccatcact tctccgcgga agccgagtcc tttgatccgg agctgctcca 2842201 tttgttcgga agcggcatgg acaatggttt ccttcagttc ttctcccgtc aggcggacag 2842261 ccaccgggtt gatcggatgc ggacagatgc ggtgcagatc cagctttgtc acaggacctg 2842321 cttttagcgg accgagaatg acacctgaat tgaccatact gatgtccgtc tcgcaccatt 2842381 cctttaaggc gtatgccaaa agcaaaggca gctctgattc ttcaaaccac ttcacctcag 2842441 catcttgtgc aagctctgca acggcatcgg acagtttctc ctcggcttca cgttcttttt 2842501 cattgagaaa cgctttagtt tctgcggatt ctcctgtcca ttccgccatg ttctgcacag 2842561 aagccgtttt gctgttgatg cttcgctgta cgctgtccac cgtgatttct acacagccga 2842621 cataatgccc gtatttctcg gcgctggcca gcagtacccc attaaccact tgtccatctt 2842681 cgagcaaatg atgggtatgt gattcgagga ttacatcaat ctcaggcacc gcttcagcca 2842741 ctgcttgatc atcaagaatg cctaaatgtg acagcagaac gataatatca gcctgccctt 2842801 tcacttccag aatggtttcc tttatgcttt caagggcatc cgtaactgtc catcccagct 2842861 tgtcatatac aggataatac ggcacagtta cacctaagaa agcaatggac ataccgtttt 2842921 tcaatgattt gatatggtaa ggcaccgccc aggacggacg gtttccattt ttatcaaaca 2842981 ggttagagac gatgacagga aattcagcat gatcatataa ggcagcaagc tcttcatgcg 2843041 gaagcgtaat cccttcgtta ttgccgatcg ccgctccatc aatgtgaagg cggtttaaga 2843101 gatcgacatt cgcttttccg aatgtcgcct ctgtcacgaa ttgaaaacga tcaagatgat 2843161 cgccaatatc aaaaacgagc gtctcttcgc cgtctgactg atgctctttt cttttctgct 2843221 cgatataatc tacaattttc ggccagtttt caaaatggct gtgcaaatca tttgtatgat 2843281 ataagcggag cttctccttc ataatatctc tccctaatcg ttcagctgaa aatgccttca 2843341 taaatgagct ggcagccgat caaaatcaat acgatccgca tgatcataac gatcgttttc 2843401 gtctgcattt ttctgttgat ggcggcgcca agctttccgc cgaaccaagc gccgggcaca 2843461 agcgcgaggg cgtacagcca attgacgtgc ccggaaatca tatgtgaaac agaccctgtc 2843521 atagaagaca ggaaaataat aaacatggac gttgccaccg caaccttcgg cggaaacaga 2843581 aataacagca tcatcgccgg aaccatcagt gatccgccgc ctataccgaa aagtccgcct 2843641 aaaaaaccga caacaaaggc aatggcaata ccgacagagg cctgatatga gtacgtataa 2843701 ggctcaccgg catcatcctg aaatgtccgg ataattcctt tgtgcgcttt gttgattggc 2843761 cgggctttcg ctttcagcat taaggataat gaaatcagaa tcataaaaat gccaaaccaa 2843821 acggaaaacg agtttgaatt gaacagcttt gacacgtaag ccccgatcat gctgccggga 2843881 cccgaaccga taaagaaaat gagtccgctc ttataatcaa ctgttttata tttaatataa 2843941 gccaaagttg aagaaaggcc cgtaaaaata atgaccaaaa gcgaagttcc aatcgcaacc 2844001 tgcggcgtca catcctgaaa cagctgcgtc actgtgctta aaaacatcag agatggcaca 2844061 atgacaattc cgccgccaag cccgatcaga cttcctaccg tacctgcgat taatcccagt 2844121 acgaccaaaa tcacaaacga catcaatcaa aacctctttt ctaaaataaa tcgagctgtc 2844181 tcggagcaag tccgctgtac tcgatatcaa gcagttcaag catctgcttg ccattatccg 2844241 cagcgtcacc gccggaattg ttgttgaaca ggacaaaaac atccttacat tgctgctgca 2844301 attcattcag gtgctttttc caatcctcca gctcctgttg gttgtagcgg tataagtacc 2844361 tgacctcccg ccagtttttc ccgccatcag gcttcatcca gccctgcttg ttgcgtccgt 2844421 gaaacctgac gagcgttttg ttttcatcgg tcgcgcgcaa cacggtcgga acgctgcctt 2844481 ctccgatttg cggttcatca cagacactgt gaatccagcc ttccgctttc ataaatgaaa 2844541 gcgtctgctc ataaaatggc ggcgagaacc aggaacggtt tctgaattca agcgcgcaag 2844601 gaatatctcc catttggtgc ttacaccatc tcaaataggc gacattctcc ttcttgcagt 2844661 caaaccacgg cggaaattga aacagcacca tggcgagctt attgctatgt aaatatggcg 2844721 ttaaagacac cttaaacgca tcaaacatct cctcttttga gtcaaaggga atttcgccgc 2844781 gctgatgccc tgtcatgccc tgatatgctt tcacgataaa ttggaaggtt tcgggcgttt 2844841 ccttcaccca cttttcatta ttgcgcgccg gctgaatcgc gtaaaagctc gcgtctaatt 2844901 ccacgatcgg aaaatgggag gaataggcct gcaatttttt ctggctggcc gttttcggcg 2844961 gatagatgct gtcatgatcc ccccatcccg tcagtccgat ataaatcaca ctcattcacc 2845021 tctcttccag tttatcacac gtgttttcag gtttcctcgg aaatgctgtt catatggcgg 2845081 gaaaatgcct cacgcaaatg ctgatattgt tcctcattcg tatctaaaaa cgcctcttct 2845141 cttgaggaag gaatgtgctg atattcaata ggcgcctgaa actgctcact cgtaaaatcg 2845201 tacaccacac cattgatgct gttataaaaa tgccagctct catcgactct tgttttgaaa 2845261 atcgtgccgc cgaaatggtc ttgaatcacc aatgccgtca cgccgcattg gccgcatgac 2845321 gggcattctt ccgtccattt agagctcgaa tggcgcgacc aggattgctt aagtatgtat 2845381 ttgacatgct ccattgcctc cgcctccttt aaaaaaagat accacgttga tgagatttta 2845441 aaaactagaa cggaggaaat caaaaaaccc ggcggtaaaa tccgccgggc ttacgaagga 2845501 acgaccagag ctccgtcaat ttcagtgact ttttccccat cattgtacac gcaccggcct 2845561 ttgctgtaag tggccgaaat gctgcaggga aatgtatgtc cttcgtaaat gcttttttta 2845621 tgctttgcaa acatcgattc tcttgtaaca gtgtacggct ccatgctgac gagcacgaaa 2845681 tctgcatcac accccgcctc aagccgccct tttttctgaa ggccgaatcg ttttgcaggg 2845741 gccgccgctg tccattctgc gatggtttca aatggaatct gatgctcaag cgccagttcc 2845801 agcattccta ataaagtgaa ctgcccgccg ctgattccgc cccatgataa aaacatgtta 2845861 tcctcccgct tcaaggatgg acggcaaggg gaatggtctg aggaaaccat gtcaatgtcc 2845921 ccggcaatga gcgtctcgat cagcgtctct tttgattgcc gtgaccggag cggaggcgcg 2845981 cattttgcga cagagcccct ttgccgtaaa tcgtcatggc tgaacaagac ataatgcgga 2846041 catgtttcaa ccgaaacatc aagaccttcc tgtttcgcct ctctgatcag ccggaccgct 2846101 ttcgccgtgc tgatatggac aaaatgaacc ggacagcctg tcaccttcgc atactgaatc 2846161 gtgcgataca ccgcttcaac ttctgcttcc tccgggcggg aggcggcgta cgcatccgca 2846221 tccacctttc ctttattggc caaaaccatc tgcaagtagc ttgtgatcgc gtcgctttcc 2846281 gcgtggagag cgaggatttt tcctgcagcc gcgatttctg ccatgccttt gagcaatgtc 2846341 cgttcatcaa cagagcggaa ctcatcagtg cctgactttg ataaaaacgc tttaaacccg 2846401 atcgctcccg cttcagccat cggacggatg tcctcgatat ggcctggcac aaggccgccc 2846461 catagcgcaa aatccacggc agatttttgc ctgcctagct cagcttttgc gagaagatgc 2846521 tctgccgtca cggttgatgg aatacagttg agcggcatat caaaataggt agtgcaaccg 2846581 cctgcggcca tcatttgaga acctgtttca aacccctccc aatcctccct gcccggttca 2846641 ttaaaatgaa catggcaatc tatcacacca ggaaacacgt atttcccgtc tgcctggatg 2846701 atttccgtcc cgcttgcttc aatgtcagaa cctatctcgg caatgacacc gttttgaact 2846761 acaatatcag cttctataac gccatctggc gtaactgcct tcgcaccttt tatcaccata 2846821 tcgtaagcca tattgatccc cccatgtcag gatgacgatt ttccatgtca gtttatgtaa 2846881 cacaaccagt tctattttca acagtttact gctactatga tcgtattaca tcagcaaaac 2846941 cgctagaatt cctattgaaa attattcacc ttaaccaatg tttttataga aaaggagaat 2847001 gcgctatgaa tattcttgat gtgatgaaaa taccggcttt tgaaaacgcc aatttaatcg 2847061 ctggaaaagc aggaggggaa agagaggttc agcatgtcaa tatgatggac gctccggata 2847121 tcgtagactt tttgcataag aatgaattgc tcgtcaccac cgcctatcac ctgaaggatc 2847181 acccgcatca attatctgaa ctgattcggc aaatggcaaa acgcggctgc gcgggcctcg 2847241 gcattaaaac aaagcgctat ctggaagata tcccgaagga aatcatcgaa ctggccgatt 2847301 catatgcgtt tccgatcatt gagcttccgg aacacatccg actcggcgat attgtgaatg 2847361 ccacactcag ccatattctc gatatgcgtt ctaacgagct gcagcaagcc atttacgcgc 2847421 acaaaaaatt cacaaaccac attatgagcg gcaaggggct gcaatccctc ctcaaaaagg 2847481 tgtcagacat ccttcagctt cccgtgctgc tgcttgacca gcatgccaaa atgctgtctg 2847541 cgtctcatca gatttcagtt gagaccgaaa agctgaaagg caccctgaat accgtatccg 2847601 ggccattttt cacttgtttc tctacaatct cagatcagaa aacatattct gtcctgccta 2847661 tttataatca cgaaaaaaac tgcggctacc tgctgatacc cgacatggtg caggcaggcg 2847721 acaaaggatt gatcctcacg attgaacaag cggccaacgt catttccttt gaactgctga 2847781 aggaaaatgc gctgaagcag ttcagccggc gggcccgcaa tgagtttttc aacaatttta 2847841 ttgagcggac cttttcttca gatgacgaaa tcaaaaaccg ggcgaaagaa ttcaagctgc 2847901 gctgggatca aaaatacatg tgcatcgccg gcaaactcga tcgcaatgac gaatcaatca 2847961 gctttacaga aaatcagctc gcttccgaca gcgtattcga atttcttgaa ggtgaattat 2848021 cagccttccc gtttccacct cacttcttta tgaaaggaaa tgtcggcatt attctaatcg 2848081 aggcgacaga cagctggagt gaaatgcacg cctcggtgat cagcttttta gaacagtttc 2848141 aaacacaggt cagcgctcaa tttaaacgaa ccgtgtcctt tggcatcagc aatatctgcc 2848201 aaaagctcat tgatgttccc gacgctttca cagaagcttc tgatgctctg caatcggggc 2848261 atttgtcaag aagcaccgca tttatccagg tgtatcacgc caaagatgtg cctgagcttc 2848321 tgcgcttgct cccagttgag gatttgaaga aattttacaa ctccacgctt cagagcctcg 2848381 ctgaaaaaca gcaggaggat caaagcctgc ttcatacgct ttccgtctat ttagagacac 2848441 actgccaaat ttcagagacg gcaaagcgtc tgtacgttca tcgcaatacg gtcatatacc 2848501 gccttgaaaa atgcgaagag cttctgggga aaagcttaaa agatcctgaa acaacgatgc 2848561 gtttgcggct tgcattacgt atgcagcggc tgatcagcta aagtttgtta cattttctta 2848621 caaaacgaat cgtttttcgt cactttcagc aatcacacct gtctttttca gctactgtat 2848681 ccaatgacac ccctcgaccg gaacgatatt atgttactaa agttcacata cagggaggga 2848741 ctatagtgaa aaaaagatcg tttaaggtgt ttacacttag cctgcagcat gtgctcgcca 2848801 tgtatgcagg tgcgattttg gtgcccctgc ttgtcggcag ggcgctgaat gtaacaactg 2848861 aacagctgtc ctacctattg gcgattgacc tgttaacatg cggcgtcgct acgcttttgc 2848921 aaaccttgcg cggaacatac atcggcatcg ggcttcccgt catgcttggc agttcatttg 2848981 tggccgtcac cccaatgatt gcaatcggca gcaattacgg cattcacgcg atttatggtt 2849041 ccatcattgc ggccggtgtg ttcatctttt tgtttgcgcg ttttttcggc aagctgactg 2849101 tgttatttcc tcctgtcgta acaggtaccg ttgtgacctt gatcggcctt tcacttgttc 2849161 cgacaggtgt gaaaaatatg gctggcggcg aaaaaataaa cggcagcgcc aaccccgaat 2849221 acggttcgct cgaaaacctt cttctctctg tcggtgtcct tgttctgatc ttagtcctca 2849281 accgctttct caaaggattt gcccgaacac tgtccgttct gatcggcatc gccgccggaa 2849341 cagcggcagc agcgatcatg ggcaaagtca gcttttcttc tgttacagaa gcaccgttct 2849401 tccaaatccc gaagcctttt tacttcggag cccctgcgtt tgaaatcggt ccgatcttaa 2849461 cgatgctgat cgtcggaatc gtcattattg tggaatcaac cggcgttttt tacgcaatcg 2849521 gaaagatatg cggcagacct ttaactgaca aagatctcgt caaaggctat cgagcggaag 2849581 gaatcgccat tctcatcggc gggctgttca atgcctttcc ttataatacc tttgcgcaaa 2849641 acgccggctt attgcagctg accaaagtga aaacaagaaa catcgtcgtt accgcaggct 2849701 gtatccttgt ctgtctcgga ctgattccga agattgccgc ccttgcatct gccgttcctg 2849761 ctgctgtact tggcggcgcg accgtcgtca tgttcggcat ggtgattgcc tccggcgtca 2849821 aaatgctcag cacagcggat ctcaaaaatc aataccacct cctgaccatc gcatgctcaa 2849881 tcgcactcgg catcggcgcc agcacggccc ccgggatttt tgctgaattc cccgctccga 2849941 tccggattct ggtcagtgac ggcaccatca ccggaagcct aaccgccatc tttttgaatc 2850001 tatttttcag cttgcgcgac aaaaaagaat taacagcaca gcaaacagaa cttccggtat 2850061 tagaacatac actcgcatta gaaaaagagg tgtaaaaaag atgaaggaac agcacaatgc 2850121 cttacagcta atgatgctgg ggcttcagca catgcttgcc atgtatgcgg gagccattct 2850181 cgttccgttg atcgtcggag cagcgatcgg gctgaatgcg gggcagctga cgtatttaat 2850241 cgcgattgat ttgtttatgt gcggggcggc aactcttttg cagctctgga gaaaccgata 2850301 tttcggcatc ggccttcccg ttgtgctcgg atgcacgttt accgcagtcg gcccgatgat 2850361 ttccatcgga agcacttacg gtgtcccagc gatatatggt gccattatcg ccgcaggact 2850421 gattgtcgtc ttagccgcgg gcttcttcgg gaagcttgtc cgtttttttc cgcctgtcgt 2850481 aaccggatca gtcgtcatga tcatcggcat cagcctgatt ccaacggcaa tgaataacct 2850541 ggccggaggt gaaggaagca aagaattcgg ctcactcgac aacgtgctcc tcgggtttgg 2850601 cgtcacagct tttatcttat tgctgtttta tttctttaaa ggctttatcc gctccatagc 2850661 gattttactc ggtcttatcg caggaacagc ggctgcatat ttcatgggaa aggtcgattt 2850721 ttctgaggtt ttggaggcgt cttggcttca tgttccgtct ctgttttatt tcggaccgcc 2850781 aacctttgag ctgccggctg ttgtcacgat gcttctcgtt gcaattgtca gcctcgttga 2850841 atcgacaggc gtttattttg ccctcgctga tatcacaaac cgcaggctgt cggagaagga 2850901 tctggaaaaa ggctaccggg cagaaggcct tgcgattttg ctgggcggct tatttaacgc 2850961 gtttccctat acagctttct cgcagaatgt cggcatcgtt cagctctcaa agatgaaaag 2851021 tgtcaacgtc atcgccatca caggaatcat actggtcgcg atcgggctgg ttccaaaagc 2851081 agcggccctg acaacagtga tccccacccc agttctcggc ggcgcaatga tcgtcatgtt 2851141 cggcatggtc atttcttacg ggatcaaaat gctatccagc gttgaccttg attcgcaagg 2851201 caacctgctg attatcgcct cttccgtcag cttggggctt ggcgctacaa cagttcccgc 2851261 gttgttttca tctctttcgg gcgcggcctc tgtcttggca ggaagcggaa ttgtgatcgg 2851321 cagtttgacg gccattgcac tgcacgcttt ttttcaaacc aaacagccga atagcgcaga 2851381 cataaaaacg taaaggaaga tgccaatgtt cacaatggat gacctgaacc aaatggacac 2851441 acaaacactg acagacacac ttggctctat ttttgaacac tcttcatgga ttgcggagag 2851501 atccgcagca ctacggccgt tttcgtccct ttctgatctt caccgcaaaa tgactggcat 2851561 tgtaaaagct gcggatcgcg agacacagct tgatttaatc aaaaagcatc cccggctcgg 2851621 aacaaagaaa acaatgagcg atgactcggt acgagagcag cagaacgcag ggctcggcaa 2851681 attagaacag caggaatacg aggagtttct catgctgaat gaacactatt atgatcgctt 2851741 cggctttcct tttattttag cggtgaaggg aaagacgaaa caggacattc accaagccct 2851801 gctggcaagg cttgagagcg aacgagaaac ggagttccag caggccctta tagaaattta 2851861 ccgaatcgcc cgctttcgtc tggctgacat catcactgaa aaaggagaga cgcaaatgaa 2851921 aagaaccatg tcttatggca aaggaaatgt atttgcatac cgaacgtatt taaaaccgct 2851981 cactggagtg aagcaaatcc cggaatcatc ttttgccgga agagataata ccgttgtcgg 2852041 cgttgatgtg acatgcgaaa ttggcggaga agccttcctg ccatcattta cagacggaga 2852101 caacactctc gtcgtggcaa cggattcaat gaaaaacttt atccagcgcc atctcgcatc 2852161 ctatgaagga acgacaaccg aggggttcct acactatgta gctcaccgat ttttagatac 2852221 ctattctcat atggacacga tcactctgac tggcgaagac attccgtttg aagcaatgcc 2852281 tgcatacgag gagaaagagc tcagcacaag ccgcctcgtc ttcagaagat cgcgtaatga 2852341 acgaagccgc tctgtgctga aagcagaacg aagcgggaat accataacga ttacagagca 2852401 atacagcgaa atcatggatc ttcagctcgt caaggtgagc ggcaactcct tcgtcggctt 2852461 catccgggac gaatatacga ctctcccgga agacggcaac cgcccgctgt ttgtctattt 2852521 aaacatcagc tggcaatatg aaaatacaaa tgactcatac gcttctgatc cagcacgcta 2852581 cgttgcggct gaacaagtcc gcgacttagc gagcaccgtt tttcacgagc tcgaaacccc 2852641 ttcaatccaa aacctaatct atcatatcgg ctgcagaata ttagcgaggt tcccgcagct 2852701 cactgatgtc agcttccaat ctcaaaatca cacgtgggat acggttgtcg aagaaatccc 2852761 gggctcaaaa ggaaaagtct acaccgaacc gcgcccgcca tacggtttcc aacattttac 2852821 cgtgacaaga gaagacgccg agaaagaaaa acagaaagcc gctgaaaaat gtcggagcct 2852881 gaaagcctga tgggaaaact gacaacccat attttagatt taacctgcgg caaaccagcg 2852941 gcgaacgtaa aaattggatt gaagcggctg ggcgaaagta ttatgaaaga ggtatacact 2853001 aacaatgacg gcagggtcga tgtccctctg ctggctggtg aagagctgat gtcaggagag 2853061 tatgtgatgg aatttcatgc aggagactat tttgcgagta aaaacatgaa cgcagccgat 2853121 cagccgtttt taaccatcgt caccgtccgt tttcagctag cagatccaga tgcacattat 2853181 catatcccgc tcttgctgtc gccgtttggt tatcaggtgt atagggggag ttaagaagga 2853241 agcccgcctc accggcgggc ttctttttgc acttcaatta acttttgatc ctaggacagt 2853301 acttgaagtg atccccacac ttagtgaaac aacagctaga ataaacattc acctatattt 2853361 ttcaggataa ttgcctacga gaaaaatacc ctgtagtcct ttcatttata aatcgaggtt 2853421 tcaaactaat aagtcagctc ttagcagccg agctcccttc tccaatccta taaacagacc 2853481 gcgttttttc tcgaaaaaat actctgaaga caattgctgc gtttttaata gttttgataa 2853541 cgcgttctct cttacacctt tagacaaaat attcattttt tcttttttag acttaaatct 2853601 atgtcgaaaa taatcgttgg catatcttat cctatctcca ctaaaggagg tgacattatg 2853661 ggattctaca attctggtgg atacagtgga aactctggtt actcaaacgg tttcgggagc 2853721 tccttcgctt tgatcgtggt gctattcatt ttgttgatca ttgttggagc agctatcttt 2853781 aattattaag tttaactttc cttgcctccg ccgtatccaa cacctccctg tccgacagac 2853841 gccataagaa gtttttatgg cgtctttgct atgtgttcac taatcttttt gtaatccaga 2853901 agctgtcaag ttctacgaga tttatcgtgt gttttcccac aacgcttctg cgtcttgatc 2853961 gcgctgtctg actgaggcta aaaaagtccg gcttttaaaa gccggactcc cgtctacccc 2854021 cgttcaactc tcttctaatc ctgcaagctg accgcataat cccgccatac ccggtacacc 2854081 ggcacaaatt ccccgccagc ccttcttcta tatctttgtc agaaggttga ggggtttccc 2854141 gaaacaatgc tttaagcgca atgatcattc ccggcgtaca gtagccgcat tggaagccgc 2854201 cttcttccag gaaagcggtt tgacacatat ccagctcttc tttttgaagc ccctcgatgg 2854261 ttgtgatgga atggccgtct gcttgatagg ccatcgtcat gcacgcattg gccagttttc 2854321 cgtcgattaa aatagagcag gctccgcagc ggccgattcc gcaggacacc tttgtcccgg 2854381 tcagctgaaa ttcctttcta agcaggtcac tcagatgtgt cgtaggaacg gcagcaacct 2854441 cccacgcctg accattcacg gtcatccgga actgttcctt ttttacagga aatggcccgg 2854501 cctcttttat gtccattgct tcagcccctt tctgtcgatc gcttcaagca actcttctct 2854561 tgaaattggc agcttgttta tccagcatcc gaccgcatca tgtactgcct ttacaatcgc 2854621 cggagtgatg gcgattgttc cgatttcacc aacaccgcgc ggtccatata cgtctccctt 2854681 cattaagtct tctattgcaa tcagcttcat gtcaggaaca tctttgattc cgggaatcaa 2854741 atagtgatcg agattttccg cagcataacg gccatccgtc attttcgctt cctccatcag 2854801 tgtgtagccg agtgccatgg cagcgccgcc ttcaatttga cctcgatatc cctgcggact 2854861 gacaaccgga cctgccgcaa tagcgtgctc acaatctatc aatttgacat cgcctgttaa 2854921 cagatctacc tccacctcaa cggcagccgc tccaaatgag tagaggaaat ggccgcccac 2854981 cacaggatca ggcgttgttg gaaagtcaaa ggccgtttcc tctgccaaag ggcctttttc 2855041 agccagctcc ttatacgtca ccacgagcgc ctttgtgttt ttgtcacgca agcctgcagc 2855101 gccgggaata agattttccg ctgaacagcc gctccattct gccgcccgtt ttttcaactg 2855161 agctagaaac ggcttcttca aacgctggat cgcgtgccac accatgcttg tgccgcggga 2855221 tgctgtggag gagcctgact tcggcacttt tgcggtatcc ccaataacaa tggaaatatc 2855281 ctctgcggca caacccagct cctccatgac aatctgttca atcgctgcta gaatcccctg 2855341 tccgcattct tcaaatccaa acgaagcagt gattttgcct tcactcgaaa gagacaaacg 2855401 gcctcctgcc gcatccattc ggccaaaccc cagcccgccg ccgtgcattg taattgccgc 2855461 tcccgtgcct ctttgcagat acccgcagtt ccggcttgtt tttttaagaa tgggagattt 2855521 agatatggca ttcaacacct gtgccgctcc gtcagttggt gcaattcgat gctcaagcgg 2855581 ccccaagtca tgcggttttc tgatattttt tcttctcagc tcgagcgggt cgatgccaag 2855641 catgccgctg agacgatcga gatgggtttc gagtgcaaat gtgatttggt tgccgccaaa 2855701 gccccgaaat tcccccgcca ccccgttgtt cgtaaatact gatattcctt cagtccggat 2855761 attcggaata cggtacggcc ccgcggcatg ctcgacagaa aaatcaagaa cagccggtcc 2855821 gagcgtagcg taagcgcctg tgtccgccac aattttcacg tcgtgcgcca atagatttcc 2855881 cgaatgatct gcacccgttt ttatcgtaat cttcatcgga tggcgcttaa tgccagaacg 2855941 tacagattcc tttcgtgtct gatgaatttt gacagggcgt ccgcttttca gggccaaaag 2856001 cgcagcatac ggctgaatat tcagctcatc cttccctccg aacgagccgc ccatcggact 2856061 tgacacaatt ctgatcttct cttcaggaat atcaaaaata cgggcaagct ggaaacggtc 2856121 tttatagccg tgctgggttc ctgcatacat cgtaaaaccc ccgtcgtctt ccggaacggc 2856181 tacacctccc tccgtttcca tatacgtatg catctgccgc ggcagctcat aggtttcttc 2856241 aaagactgtg tcagatgctt gaaacccttc ttccacatca ccgtttgaaa aaaatgcgcg 2856301 gtgcaggata ttcccgtcct catgcagtct ttgcgcattc ggccgaagcg ctttttctgg 2856361 tgaatccatg acttccagct ctttatactc aacttgaatc agctccagcg ccgcttccgc 2856421 gatttcttcc gtttccgcag caactgcggc gatcgcatcc ccgacatacc gcaccctgtc 2856481 ctcacataaa accggctgat cagggatgac aatgccaaat cggtttaagc cgggaacgtc 2856541 tttatgtgtg acgacggcct gcacgccttc cattttctca gcttttatgg tgcaaaccga 2856601 cacaatctct gcatgaggat aagcacttct cagcaccttg ccatacagca ttcctggaaa 2856661 gctgagatcg gtcatatatt tcaattcccc tgtgacctta ccccttccat ccggcctgac 2856721 tcttgacggt ttgttgatga tcatttattc ccctccctca gccatcagct ctgccatgat 2856781 gacgttggca gcggcttttt ttctgtatgc cgctgacata aaaacatctg aggaaaacgg 2856841 cagctcatgg ataagtgttt tgtacagctc atgcgggtcc caccctggtg ccatccattt 2856901 cgcttcgctg tccaataatc tcctaggagt gatatcggca tggccagcgg cgaggcgaat 2856961 gctgccgtct ttcaaaaaac gtccagctgc aacagcagcc gctccggtaa aagcctggcg 2857021 ccttccaagc ttgtgataaa atacacgctc tccctccgcc cgcgggatga tgacacgcgt 2857081 gacgatagcc gttctaaagt cttcctcact gagccaagcg ccaagcggca gcctgattag 2857141 ctccttttga tatacgataa gctcagcacc aagcacaagc agaagcggaa tgaaatcacc 2857201 gattttactc gctatgttgc cgccaatcgt ggcacggctg cgaatccccg gtgcagcgac 2857261 agcggaagca gcgtcactga aacagctaag cgctctctta atcaaagggt tctttctgca 2857321 ttcattcagt gatgtgagcc ccccgatcga cacgtgggtg tcactggtgc tgatccctcg 2857381 catttcgtca atcccttcaa ggctgacaag gtgctgtttc ggtagagttc ctttgtccca 2857441 ctgaagctga aggagcgtgc ttcccgatgc ggcacacaca tccggagcaa gcttctctaa 2857501 aagcgaatag gcctcatcaa gcgctgccgg tctccataat tgaatattca tccttgcttt 2857561 tgtcacttgg ccgttcaaga catcgccctc cttaccatgt catattcctc gggtgtatca 2857621 atatcgtcca actcaccgct atcctttgcc tccaaaaccg ctcctgctcc aagctgtccg 2857681 cttttcagga gcctgcgagc cccttcatct ccctttaatc cctttacata aggaaaacat 2857741 gtcgacgaga agtagattgg cggggtgaac gcccctaaaa acgatgacac ggcaaatgac 2857801 tcaggagcca gagccacaag ggcattgaga tgatcgacgg aaagctgagg ctggtcggct 2857861 aacaaaatga caatgccgtc cgcccccatg ctttctgctt ttctcacccc gctgctgact 2857921 gaatgcccct gacccttttc tgcgtcttgg caaacgtgca ggctccagcg tttttgaaaa 2857981 ggcggagcgt gatacggcgc tcctatccac tcaagggagg catgttctgt ccgctcgacg 2858041 accagcacgt gatcaaggcg ggacgacaga gcagttttca aggaaagtga gcctatgttt 2858101 tctcctttta gcggcaaagc cagcttgttt tgtcccattc ttctgctttt gccggcagcg 2858161 agaaacacgc cgatcagata ggggcttctc atacaaccgc cacccgtttt cttgtttgaa 2858221 tgatttctgc aactacactt accgcaattt cctcgggacc ttccgcaccg attttcagcc 2858281 cgaccggact gtaaaagtga gacggaggat gttttccgct cagcagccgt ttcgtgcggt 2858341 ttgccgaacc caacagtcca atataatgga ggttttgaga aaataagaag ttgatgatcg 2858401 tttgatcgtg ctgataatga tgggttgcca caacagctgc atcatgcgga aaaaattgaa 2858461 attcgctaag catttgttcc ggaaaagcgg tgatcagctg atccgctttt ggaaaaagag 2858521 aggatgtaca ataagcgggc cgccaatccg tcacgataac agaaaaccct gtgtcagccg 2858581 ccaaattggc cagcggtaca ttatccggtc ccgccccaaa cagaatgaga cgcggcttcg 2858641 gttcaattcg ctgaataaac atgttagtgg tttgatcgaa atgcggtaaa tgaagcgttg 2858701 aaacagtacg ttgaatatct tgcagaggcg cgtccggcca gttcccaaaa tgtccgttct 2858761 ccgtcagaaa taaataatgg gaggattcaa tctttataac ggaagtgaca gctttgcctg 2858821 aatgaaggca gtccctcact ttctcatagt gccgcctttt ttcctgagtg attcgctctg 2858881 catgaacatg aataatgcca ttgcacccgg ctcccatgcc ccaagaaaga tcgtcctccg 2858941 accgcatgtc gtagggaatc agcgttgatg tgagctgatc gcccagcgca ctgattcttt 2859001 ggaatacatc ttcttccaca cacccgccgc tcagcaagcc aatccgtctg ccttttttct 2859061 taaagagcat agaggcgcct gcttttcgat acgcggagcc ttcaacttga acaattgtcg 2859121 ccagtacagc ctcctcctgg tcttccagga gcgcatctaa catcgtgtga aaattcccca 2859181 atgccgcatc ctcctctcga aaattgccgt gagaaacaac tagttcagcg tgattttata 2859241 ggtaacttgt ataaagaata gacgatggaa gaaaaaatga ctcatgattt gtcagaaaat 2859301 gaaacacata gaaagaggat ttgtaaaaag agtcaaacga agaaaatcag attggagaaa 2859361 acacgaaatc atatcgttaa aaagcttgcg gagttccgca agcttttctt tacaccgctg 2859421 cctggcggcc agcgttttca tacacatcca gcgctgcttg gagcgctttt cctgcttcga 2859481 ttcctgcgtt atgtctgaga agcacagcct ctaacccggc aagcacgaat agcacgtttt 2859541 cttttctgca gctgtacccc atcgtgccga tcctccagat cttccctgca agcgggccga 2859601 atgagctggc gatttcaatg ccgaattgtg ccagcagcat gtcacggaca gactcgccgt 2859661 caatgccgcc gggaatttcg acacaggtga caacaggcat tttgcagctg tcatctccaa 2859721 acaatcttag ccccattgcc tttatccctg ctgctaatgc ggcttcatgg tgccgatgcc 2859781 gctcgaaacg cgtctcaaga ccttcttcaa gcaccagtct gactccctca cgtaaggcgt 2859841 acagcatcgt cgtcgcttct gtatgatgat tgagccgtct ttcgctccaa taatcctcaa 2859901 gctggctcaa atcaaagtag ttgcttgtaa ttggccgatt tcccgaaagt gctgccctgt 2859961 cagcttgtgt cgcaatcccg cgttccacct ttttgcgagc tgcaatcacg tccgccaccc 2860021 gctcattata tgtaatcggc gccattcctg aaggcacaga caaacatttt tgcgttccgc 2860081 cgatggcagc gtcaatcttc cattcatcga ctttaacctc gcagccccca atcgttgcga 2860141 ctgcatcgac gataaacaat gcatcctcgg tgcggcaggc ttcgccgatg gctttcagcg 2860201 ggtgaatccg tcctgtcgat gtttctccat gcaccatggc cacaattttc ggcttcactt 2860261 tttttatctc ccgtatgatg tcctccgggt caaaaaccgt tccccattcg cactccagca 2860321 tatgaacatt tgccccatat cgctcggcga tttcagtcag caaataaccg aaacggccgt 2860381 aaatgggaat gagcacatca tcttccggct ctatcacact agccagcact gcttcaattc 2860441 ccgcccgtga agtgccgtca atcgggtatg cccagcggtt ttttgtttgg aacagctccc 2860501 gaagcatctc catcgtttca ttcataatac ctgtaaacgc cggatcaaat tggccgacaa 2860561 ccggggtgct cattactctt aatacacgcg gatcaacctc aacaggcccc ggtgtcataa 2860621 tcgttcttaa cggggtgcat aattctcttc tgcctgacac agccattcct cctttatcag 2860681 taagccagtt tgtataataa atcagtcagt gcgcggacgc cgatctcaag ctgtctggct 2860741 gacgtatatt ccttcggtga gtggctgacg ccgcctcggc tcggcacaaa cagcatacaa 2860801 gcaggatagc gccttccgat catttgcgcg tcatgccctg ctccgctcac catttcctca 2860861 cagctgaagc cgttttctaa tgctgtttca aaagccgcag ccttcagcct ttcgtccatc 2860921 ggcacaggct ctatccgcat atattcatca atcacagcgc gaattccttt ttgtaggcaa 2860981 atgccgttga tcaaagcaac catgtcttga tgaaactgtt ccagcacatg ctgatgctga 2861041 tggcgaatat cgattgaaaa ctggacgcgg cccggtatga cattggctac attgggctct 2861101 gccgttattt ttccgcatgt cagacggagc tcatccggca gctcatccga ccgcagcagc 2861161 agctcatgaa tgatacggct gctggctgcg agcgggtcct tgcgccattt catggaggtg 2861221 gttcctgcgt gattgcattc tccttcgagc gtgacgagat atcgtctctg ccccgcaata 2861281 cttgtcacga tgccgagatc ccggcctgac atttccaacg tcttcccctg ttcaatatgc 2861341 agctcaacaa acgcgctgat atctgtccta tatgctgact gaaacacacc tttgccaaaa 2861401 ccgctctcat gcatcgctgt ttggagggag actcccgact cgtctcttgg ctcttttgca 2861461 tcttgttctg aaaaaacacc cgtcatattc cccgaccccc aataggtcat tggaaaacgg 2861521 ctgccttcct cctcacataa ggagaccgcc tcgagcgttt tttttggcgc tccgtatgtt 2861581 tccttgagct gctttaacgc gagcattgcc gccagaacgc cataggcgcc gtcgtatttt 2861641 cctccattga tgacagtatc gatatgtgaa ccggttacaa tgacttcatc cggagactgg 2861701 gtgcccgaaa gccttccaaa cacattgccg acatcgtcga atcttgtttc aagcccgaaa 2861761 gaagacattt ccgttttcac agcaagctgt gcgtccatcc actcttttgt gtataaaagc 2861821 ctcgttacgc cgccatccgc agacgcaccg tattgggcga gccattcaat ataatctgtg 2861881 atgctgtttt ttactgaaag cttctgcttt tccatgtact cccccctctg gccgctatgg 2861941 tgacttcatt atagaaggag caacatgata gttcattgac agattaacca aaaaaacgtt 2862001 tattttttag ccacagtatc catccagcaa ccagatacac cctacatgtc acaactattt 2862061 tgatgtaaag gtcaaaagaa aacacggtaa ggaagagagc cagcaagagc gaaagagagg 2862121 gtcaaaatgc ctttcatatg aacaagctaa gctggagagg cgatgttcgc ggaacggatg 2862181 aaaacagaaa tgccggcagc ccgcaaaaac aggacctaaa gatatggaaa caggagattt 2862241 ccgcctcctc caaagggact aatttacaat tttaatgaaa aatatacaaa atgacacttc 2862301 tatcctttat ttcaatttta gataatagat atgatctgat aaaaggaggg caagtgatga 2862361 caaaaaaagc atggtttctg ccgctcgtct gtgtattact gatttccgga tggcttgcgc 2862421 cagcagcttc agcaagcgcg caaaccacat taagccttaa tgaccgattg gcgtcttccc 2862481 cttcaggaac gggaagcctt ctctcattag ccgcccccgc tgcaccctat gctgacacag 2862541 atacctatta tgaaggggct gaaggtaaaa caggagactc gctaaaaagc accctgcacc 2862601 gtattatcag cggacacacg atgctgtcct acagcgaagt gtggaacgcg ctgaaagaaa 2862661 cggatgaaga cccaagaaat ccgaataacg tcatcctgct ctatacgaat gaatcgcgtt 2862721 ccaaaaacct gaacggcggc aatgtcggcg attggaaccg cgagcatgtc tgggcgaaat 2862781 cccatggcga ttttggtacg agcaagggac ctggtactga tattcatcat ttgcgcccgg 2862841 ctgatgttca agttaacagc gccagaggaa atatggattt tgacaatggc ggcactgaat 2862901 atgcgaaggc acccggaaat tattatgacg gcgattcatg ggagccccgc gatgatgtga 2862961 aaggcgatgt tgcccgcatg ctgttttaca tggctgtccg ttacgagggt gatgacggct 2863021 atcctgatct tgagcttaat gataagacag gcaacggctc agctccttat catggcaaac 2863081 aatctgtcct gctcgaatgg aataagcagg atccggttga cgaccgcgag cggaaaagaa 2863141 atgaaatcat ttatgaaaaa tatcagcaca accgcaatcc atttatcgac caccctgaat 2863201 gggcggatga gatttggccg taagaaaaag gtgctccttt tgaggagcac ctttttctaa 2863261 tacacagcct cttccgtttc cgcatcgaaa aagacgacgt ggtccatttt cactgagagc 2863321 tggattgaat cgcctgcatc gattcgcgtg tttccgtcca ggcggacctt gagccgctcg 2863381 tccccagcca tgacatgcac tatgagctcc gagcccagat tttcattcac ttccacgttc 2863441 gcttgaaaca ctgaatcaaa caactggtca tttcctgtca tttgtgtgat gtgctccggc 2863501 cgtacaccgg caatcatctg ttctccggca tatccctttt ccttcagccg ctttgctttt 2863561 tcttcaggaa tatgaagccg gatcgaagaa tttgtgaaaa acagctcgcc atgctgctgt 2863621 tctatgatgc ctttcaaaaa gttcattccg ggagagccaa tgaagcctgc gacaaacaaa 2863681 ttggccgggt aatgataaat gtcatgaggt ttcgccactt gctgaatttc cccttcattc 2863741 atgacgacaa tccgatctcc cattgtcatt gcttcggtct ggtcatgcgt gacataaatg 2863801 atcgttgcct ctaatcgctg gtgcagcttg ctgatttctg tccgcatcgt cactcttagt 2863861 tttgcatcca gattagaaag cggctcgtcc attaaaaaga ccttcggctc cctcacaatc 2863921 gacctgccaa gcgccaccct ttgccgctgc ccgccggaga gcgccttcgg ttttctcttc 2863981 agcaaatgtt caatttctaa aattctggct gccgcatgaa cccgctcggc aatttcctgt 2864041 ttcgccatct ttctgagctt taatccaaac gccatattat caaaaaccgt catatgcgga 2864101 taaagcgcat agttctggaa taccatcgca atatcacgtt ctttcggcgg aagatcattg 2864161 acccgctccc catcaataag aagatttcct tcagaaatgc tttctaatcc agccaccatc 2864221 cgcagcgttg ttgattttcc gcatcctgac ggccccacca gcaccaaaag ctccttatcc 2864281 tttacatcta aatcaaagtc cttcacggtt aattgtgagt gatatgattt tttgacgtgt 2864341 tcaaatgtta atgaagccat cagaaaagtc cccctatctt ttgacccgtt atttcgtcac 2864401 tggaaacaac ttggtctttc tgttattttt agagtaatcg attcccattt ttgctatatt 2864461 tctaaaataa aaaatgtaaa tttgtattat aacgtcataa tacattataa tataaataat 2864521 aggttaaaag gaggctaccc tttgttaaac aacggaagtt ctacaccttt atacattcag 2864581 ctaaaacaaa tcatcactga tgacatcaaa aagggcgtgt attccccaac cgccaagctg 2864641 cctaccgaaa acgagctttg caccaagtat aacgtcagcc gcatcaccgt caggaaagcc 2864701 attctcgatt tagtcgaaga aggctatctg atcaggcagc agggaaaggg aacgttcgtt 2864761 aaaagcccta aattaaaacg agagctgatc gctgtaaacg gctactcgga atttatggaa 2864821 tcaaccggca aaaaaccgaa gcatcatgtg ctgtcccatg acatcattcc agcgtcaaaa 2864881 cccatcgccg aaaagcttca aatccaaccc gagagccctg tggttgaatt aaaacggatt 2864941 ttatataatg atgatcagcc tctcaccttt gaagtgacgc attatccgct tgatttgttt 2865001 cccggcattg atacctttat tgctgacggc gtctccatgc atgatatttt gaaacagcaa 2865061 tacaaagttg tacccacgca caatacgaag ctattaaacg ttgtatatgc ccaacaggag 2865121 gaaagcaaat acctggattg tgatatcggg gatgcgctgt ttgaaattga taaaacggct 2865181 tttacatcaa acgaccagcc aatctattgc tcattgtttt tgatgcacac aaaccgtgtc 2865241 acttttacca tcaacagccc ctacacataa caggcataaa aaacgagaca ctgcttatag 2865301 tattctcgtt ttttcactgc ttcccccgtc ctccaagcga taaggatagc catagccgaa 2865361 agctccgtac acaccgcaag ttttcgcagc cgtttcagca gcctggcgca aagcatacgt 2865421 tatatcctgc ttcacgcaaa aggcagtcaa aaagcctgct ataaaagaat ctcccgctcc 2865481 aagtgtatct attatatcag cttccacaat cggctgatga tagactcgat cacccgcaga 2865541 caggattgct ccttggcccc ctcgggtcat acaaaccatt ttggctccgt acccatgagc 2865601 tgttttggca agctcaccgc attccgactc actcaaatcg cttcctgaaa aaaacgcata 2865661 cgtcacataa ggacagaccc tcctcaaata atcatcctcc cgattggttg aaaaatcaaa 2865721 tgagaccggg accagcccgc acagctgcgg aagatcgttc tcaagcctgc tgtacacgct 2865781 cgtatgcagc agatcatgcc cgctgataaa agatacatct ttctcctgaa acgcgaggcg 2865841 aagccgggac tgaatgccgc ctttatttga tctgacaaaa atgcggtccc cctgttcatc 2865901 aagggtgaca atcgccatcc cgttttctcc gtgcgcctgg cggatataat ctgcattgac 2865961 ctgctccagc ttgagaacgt tcaacagatg cgccgcggct tcgtcattgc cgacgattcc 2866021 gatataggaa gactcatgcc cgagccgctt ggcaagcaca gcaacgttta aggcatttcc 2866081 tcccgggtaa aatgtttctt gatcctggta gtaatctaca acattatctc caaccgcaat 2866141 caatttcata gcgcttcctc ctttatcctt ttacactgcc gcttgcaatc ccgcggacaa 2866201 aatatttctg catcaataaa aatagaataa taatcggcgc ggctgaaatc gttaaccccg 2866261 ccagcaggac gccccagtct gtctgcagcg cgtctctgaa ctgcatcagc ccggctggaa 2866321 tggtccgtaa attctcatca tctatgaaaa taatcgcaaa cataaactca ttccatgtat 2866381 ggtaagccgt caaaatgccg gatgtcacca aaatcggcac gctcattggt aagaaaattc 2866441 tgaaaaatac tccaaaactt gtacacccat ccaaataggc cgcctcctcc aattcttttg 2866501 aaatagaaag aaaataagag cggatcaaaa tgatggtgaa tgggatccga taagccgcat 2866561 acggcaagat taacgcccaa tacgtattgt acaggcccag cgactgaata atagaataaa 2866621 gcggcacaag actgacctgc ggcgtcagca tcaatccgcc aagacatagc accaaaaaga 2866681 atccttttcc tttaaactca aaccgggaaa ggccatacgc tgcccatgca ctgataaaga 2866741 cagtgatcac acacgtcagc gccgtaacga tgacactgtt cataaaataa gaagaaatcc 2866801 cctgattcca ggcggaaaca aaattttccg gatgccacga agacggcagc gaccagctgt 2866861 gctcaaaaat atcgtcagag tttttaaagg cgctcatcac catccagaga agcggatagg 2866921 caatcgcaat cagataaaga aacagaaaaa cccacacaga cgtttctccg atataccatt 2866981 ttcgtctagg cttatctttc acctcaatgt gctggtcagg caccggctcc aatctgaacg 2867041 aatctgtctt cttctgaggc agcatcagtt actcctcctt tccggtttta aagaacttca 2867101 tttgcatgag cgataatgca agcgtaatga ttaacacgac agtggcaatc gctgaggcgt 2867161 agcccatcat atcctttgta aaggcgcttt tatataaaaa cgtgctcaag acttctgacg 2867221 cttttcccgg cccgccgcct gtcaaaatgt acggctcatt aaagaccgta aaggctccgg 2867281 tcagcgtcat gaccaccgca acaaaagaca tctctttcgt ctggggaaca gtaatatgaa 2867341 aaaactgctg aattttaccc gcgccgtcaa gccgggccgc ttcatacagt tcatccggta 2867401 ttttttgaat cgacacgatg tacagcatcg caatataacc gacagattgc cactgggaca 2867461 caaaaatgac agaaagcata gctgtgctgt catccccgag ccaggccctc gtcagctgat 2867521 caagaccgat ggcctgaagc agctgattca aaagccctgt ctccggattg taaataaaat 2867581 caaacaaaag cgcgatcacc gtcattgaga tgacaaccgg caaaaagaaa acggtacgaa 2867641 aaaacggcga ccattttctg accagcttat cctcaagcac cgccgccaaa atcaaaccgc 2867701 caaatacctg gcatacaatt gagatcactg cataaagcac attattggta agtgcctgat 2867761 agaagacagg atcatgaaat aattcaacat agttttttaa gccgataaac gttttttccg 2867821 gagaaaatga gctccactga aacaggctga ggaatacatt ctcaaaaatc gggatataaa 2867881 cgaaaagtaa aaaaacgaga gcgggcacca aaaacaaata ggggattatt ttattctgat 2867941 tgaccaaggg tatctcatct cctttataaa aagaaaaggt gcgaagcttc accttttctt 2868001 tgatttattc agctgacgcc ctcacctgct ttgctgcctt ttgaacggct ttcatcacct 2868061 gctgcggtgt catgtcgccg ccaagcattt gctggacgcc cgttaggtac gcatctgcga 2868121 cttcaacatc gacatccata tcaaaccatg gaaccattga tttggcatca acaatatgct 2868181 gaacggcttc acgctgaatg gctgttgcat tttcttcagt agccgtacct tgcactgcac 2868241 tgtatttccc gacatctttc acgagctttt cgcccattct tttcgacgtc aagaactgca 2868301 aaaattccat cgcttccttc ggatgttttg ttcttgagga gatcatgaat ccttccggcg 2868361 ctcccgttaa cgcttctgaa gatcctttct gcccgctgat ttcaggaaat gggaacatcc 2868421 cgagattaac cggttcaacc agcttgattt ccgctgtttc cgcatatatc atcgccgact 2868481 ttccgctctt aaattgctgt ctcacatatt cgtggtcgac ggagtttaca tgtttattaa 2868541 agtaaggcat cagctcttga agcttttcaa gtgcttttac gtagccttca tcagtaaatt 2868601 cacccgtttt ggcgttatag tccttttccc gtgttttttc atcgaccatc cgctgattaa 2868661 gcgtgccgat atagtgcgag attgtccaag tcgcctttgt tccaaagctg atcggtgtgt 2868721 agccatgttc tttcagcttt tttgacacat cgattaattc atcccacgtc ttcgggggat 2868781 caagattcag cttttggaaa atgtctttat tatagaagaa tgatttagcg tccatttgcc 2868841 acggtacgcc atattgcttg ttttcataag taaatggtgt aatttgcgat tgaacgagct 2868901 gtgatgacca atcggtgtca tttttgtagt aggacgagag atcaagtgct ttattgcctc 2868961 tgataaattt aaaagcaaac tcatcgctcc aagagaagta aatgtcagga gggctggtgg 2869021 ttcccagcat gaccttaatt ttatctttat aggagtcatt taaaacggct tcaatttgaa 2869081 tgtcgatatc tgggtgatct ttttcaaatt ccttaacaac ctcttcaaaa taactttttt 2869141 ccggctcctt tggccatctg tggaaaaatt tcaatgtcac ctttccgtcc gctgaactgc 2869201 tttggctcga acagcctgcg atggtgagca tactgacagc tgcaatgatc aagaacaaca 2869261 acattttctt caaagggttg gcctcctctg gacattagac tataatgtta tataacatta 2869321 tagtctaatg cataatggtt cttcattttc agatcaatac tcaactttcc acatgtatct 2869381 tctatgagat aaaggatgat ttctctcctc tgccagctcg tctgcatagc ttctcagcac 2869441 acgattgaga acgagcggag caagatagcc tttaactgaa tcgtcaattg cagtgaagtc 2869501 gtaagatgca gcatcaagca cagtgagctt tttgccatac tttttcgaga aggtaagcgc 2869561 ccgctcttca agaggtcttg tttcatctaa accgagcagg atgataaacg gcacggattc 2869621 atcaataatt tcaaacggtc cgtgaaaata ttctccggca tgaatggcgt gggaatgaat 2869681 ccattgcatt tccatgagaa tgcagatgct gtaggagtaa gcgacaccgt agtttgcacc 2869741 gcttgccatg gtataaataa tgctttcttt ttcatgggct tttgcaaatt gcttggcgtt 2869801 gtcagcttcc tgcttaaggg ctttttcata tacagcctgc aattgatcta agccttcaat 2869861 tgcttgctca aatttcgtat tgttttctaa tacttgcagg gttccaaaaa cgatttgata 2869921 caaaacgcca tagtttgtat tgatcgcaag cgcctcatca ccccaatcgt actgggcaac 2869981 atattgcgct tcctgcgcta aaggagactc cggtttaaac gtcatcgcaa tcgtaagtgc 2870041 gcccttgccc cttgcaaacg cagcagcttt gactgtctcc ggggtatttc ccgaatgcga 2870101 gcacaaaata acaagagact tttcaccaag ctgaacaggg ttgcgctgaa taaattcgtt 2870161 ggcgctgtag agatcggagt ttattgattt tgactctctg tcaaacacat acttactcgg 2870221 atacataatg gcagaagacc ctccgcatgc gacaaagaat acatgatcaa tggttttccc 2870281 tttcaaatcc tgcaagaaag cttgaacctc acgatttact tttgctgtgg cctgactcaa 2870341 atccttcact cctcgttttt attatataac gttatataac attatatatt gttatattaa 2870401 agtccgcggg taggattgtc aatattattt tctgaaattt ctcaataatt tattcggatg 2870461 acagacaaag ggtctatatg cgaaaaaatg cccaaatcaa aagccagaac ttgacttaag 2870521 ctctggcttc gctgttcaat ccgcagactg acgtcttatt taaaaaatac cttgtctata 2870581 ttgtacttcg agtgctgtgt attgatgata tatgtttcgt aaatctctct ttccattgga 2870641 tcatcaacta cacatacctc aattttataa acttcatctc tgtgatgttt gatcggtgaa 2870701 acagtgtctt cgaaatgctt cttaattctc tgtcttaact ttctggcttt accgacaaac 2870761 agcagctcgt catgaatgtt gtaaaacata aaaatgccgc ctttgtccct tgggatctgg 2870821 tgaaagtcga tgaatccgtg aatcggtttt atcttcggct cgttatcatt agctgactgc 2870881 tgtcgttcag tgatggtgac attcggtgcg ggtatatcaa tttttatcaa aatcagttca 2870941 cgtcctcttt ttcattaaag ataaatgcta acacatacag aaaagaaaag ctagaacagc 2871001 tttattatat ttgtttgtca tgctcttact tattatgcaa gtgctccggc tggatcataa 2871061 ggactaaggt ctaattctgt ctgctttccg agaactagct ttgcgagctc tgcacccaaa 2871121 aacggcccca tcgtcagtcc agaagcaccc aaaccgtttg cagcgtacag gccttgaaca 2871181 ttcggcacgg cccctacgac cggcagaaat cccggtgtaa acggcctgaa gcccactctt 2871241 gtttcaacag cagccgcatc agcaagaccc ggtgcaacgg ctaacgcttt gctcaatact 2871301 tcgtgctggc ctccggctgt cacacgaaga tcatcaagac cggcatcgtt ttcgtgtgtg 2871361 gcgccggcta caattctgcc gttatcaaac gacagaatgt actgatcact cggcggcatt 2871421 acaaccggcc acgatcctgt atctgcatct gtcatttcaa aatgcataat ctgcgctttt 2871481 tgaaatgaca cttgaaaatg aatgccaaga ggcttcaata tctcattggc ccatgctccc 2871541 gccgtcacaa tgaccgcgtc agccgcaaac tgctttgtat ctgtttgcac gccggtgact 2871601 gttccgtttt caaaaagcaa ggacgcattt cctttgatga ccgttgcgcc gcgtttctct 2871661 gcagcgctta aaagcgaccg gcacagcgct cttccgttca cacgggcggc accgctgata 2871721 tgaaccgatt catagccgtc agctaaaatc ggaaacagct ttttcgtttc acttgcagac 2871781 aagcgggtaa tgtcgccgat ttccggcgca tcctcccgtc tcttatacgc cctttcctcc 2871841 attttatcga gtttagacgc gtcagtatga atgctgatgg caccgacacg tttgtatcct 2871901 gtatccgatt caccgtcttt ttccaattga tggattaaat ccttatagta ccgcgctccc 2871961 cccttagcaa gctggtacca atcctgatta cggcgctgcg agagccaagg acagacgatc 2872021 cccgccgccg catcagtcgc ttgtcccggc tctttccgat caatgacagt aacgcgagcg 2872081 cctgtttttg cgagatgata agccgtcgac gcgcccagaa tccctgcgcc gacgatgatg 2872141 tacgatttca tatgcaaaca ccttttctat tataatgtct attcatttta ccaaatcaaa 2872201 tgctttcctt cgaccttttg ccctaatgtg gaaaaaccgc gaagttcgtc caatctcttt 2872261 actctcctat cgaatatcct gtcactatca atagagaaag gatgatacca tgagcgaaaa 2872321 tcgtcatgaa aatgaagaaa acagacgcga tgcggcagtg gcaaaagtcc aaaacagcgg 2872381 taatgcaaaa gtcgtggtca gcgtgaacac agatcaggat caggcacagg cgcagtcaca 2872441 agacggagaa gactaatgaa cgaaaacatc attcctctta acagacatac tcaagagata 2872501 cccactactg aatctgttat caaaaacagc ggcaactcag aggtccatat cgacattcac 2872561 attgatacaa tgccaattgc ttttgctata ttatgctctg cattagccgc aaagcagatg 2872621 acaaaagagg aattcgatat ggcttatact caattgcgag agatgaacag agaaaataac 2872681 agcagatcat ctgtaaagca aattatcaat caagagacag aagaagagta aaaaaccgcg 2872741 gcccctcggc cagcggtttt tcttctgcat acaaaaagga cgcgactgaa tcggttactt 2872801 ctgtacaatt tgaataaggt taccgcatgt atcgtcgaag acagctattg tgacttcgcc 2872861 catttttgtc ggttccgtcg taaacgtcac gcctttttcc tttaatcggt tgtactcttt 2872921 ttgaatatct gcaacgccaa acattgtggc cgggaggcct tcggagaata tcttcttttg 2872981 atactccttg gcggcaggat gttcattcgg ttcgagtaaa agctcggttc cgtcttgatc 2873041 atctggagaa acaagcgtta tccacctgaa tttccccatg ggaacgtctt ccttttttat 2873101 aaacccaagt ttttctgtat aaaactccag tgccatgtct tgatcttgta caaatatact 2873161 ggtaacaacg attttcatac tgtttttccc tccttcgata tgaatgaagc atggtactat 2873221 gctaacaatc tggctacaag caaaacaacc cacacattta tcagaggccc tgttctgatt 2873281 ttataaaatt attctatcca tcctttcagc aaatttttaa gcggttcgtt gttgaatata 2873341 agtactcgat attttccctt tcgttttgat gttacgagtc ctgcatcctc cagtacagaa 2873401 aggtgtttag ctatcgcctg tcgcgtaata gaaaggtcgt actttgtaat aagacgtatc 2873461 gtaagttcat acaacgtcag ctcgttgcgt tcagataatt cgtctaatat aagccgccga 2873521 gtcgaatcgc cgagtgcttt gaatatagcg tctttgttcc cattcatata ttgagtataa 2873581 gcaacccatt agttgcatgt caagtataag caactgtatg gttgcgtgat atagaaactg 2873641 aacctatccg gcgcaggtct gaaatattct aatcgataag gaattaaaac cattaaaata 2873701 acagtggata tgtctctgaa aaataaaaga agacgaactt caaaagttcg tcttctacaa 2873761 tcaaattcgg cacgccggcc attttaaagt tgataactat ctctaaaccc cttgataaac 2873821 aaaggagttt tcatcattaa ccgatagaac cttccatttc gaacttaatc aaacggttca 2873881 tttcaactgc gtattccatc ggaagctctt ttgtgaatgg ctcgataaag cccattacga 2873941 tcatttcagt tgcttcttct tcagaaatac cgcggctcat caagtagaag agctgctctt 2874001 cagatacttt agacactttc gcttcgtgct ccaatgaaat gttatcattt aagatttcat 2874061 tgtaaggaat tgtgtcagaa gttgatttgt tatccataat gagcgtatca cactcgatgt 2874121 tagagcgggc gccttccgct ttgcgtccga agtggacgat tccgcggtac gttacttttc 2874181 cgccctgttt tgaaatcgat tttgatacga ttgtagatga tgtgtttggt gcaaggtgaa 2874241 tcattttcgc acctgcatcc tgatgctggc ctttacccgc aagagcgata gaaagcgtca 2874301 taccgcgcgc gccttcgcct tttaggatac aagccggata tttcattgtc agcttagaac 2874361 cgatgttgcc gtcgatccat tccattgttg cgttttcttc acagactgta cgctttgtta 2874421 caaggttgta aacgttgttc gcccagtttt ggatcgttgt ataacggcag tagccgcctt 2874481 ttttcacgat gatctcaacg accgcactgt gaagtgagtt tgttgtgtaa acaggcgcag 2874541 tacagccttc aacataatga acgcttgctt cttcgtcaac aatgatcagt gtacgttcga 2874601 actgacccat gttctcagag ttgatacgga agtaagcttg tagcggtgtt tcaaccttca 2874661 cgcctttagg cacgtagatg aaagaaccgc cggaccaaac agctgagtta agcgccgcaa 2874721 acttgttatc agtcggcggg attacttttg cccagtgctc acggaaaata tcttcattct 2874781 ctttcagcgc gctgtcagtg tctttaaaga cgatgccttg tgcttcaaga tcttctttca 2874841 tgttgtggta tacaacctca gattcgtact gagcagaaac acccgcaagg tatttttgtt 2874901 cagcttcagg aataccgagc ttgtcgaatg tttgtttaat ttcttcagga acttcatccc 2874961 aagaacgctc tgaacgctca gacggtttta cgtagtacgt aatttcgtca aagttcagtg 2875021 agtttaaatc tccgccccat tgaggcatcg gcatattgta gaaatgctca agtgatttca 2875081 agcggaagtc aagcatccat tgaggctctt ctttcatgcg agaaatttct tctacgattt 2875141 cttttgtcaa tccgcgctct gaacggaaaa tggaaacgtc cttgtcgtga aaaccatact 2875201 tgtattcacc aatatcaggc atttttttag ccatccattt tcactccaat ccttttaatt 2875261 gccgccttct tctttcgcga ctcctttttc aagtgctttc catgacaggg ttgcacattt 2875321 gatacgggca gggaattttg aaacgccttg aagggcttca atatccccga gatctataga 2875381 atcatcatac tctttccctt gcatcatatc cgagaaaatc ttagacatgg aaagggcagt 2875441 ttcaatatct ttccctttaa tcgcctgagt catcatcgaa gcggatgcca ttgaaatgga 2875501 acagccttcc ccttcaaact tcgcatcttc cacgatgtct ccgtcaagct tcattgtcag 2875561 tctgatgcgg tcgccgcatg tcggattgtt catatccacg acaatgctgt catttaaaac 2875621 ccctttattt cgcgggtttt tgtaatgatc cataatcacc tgtctgtaca atgtatctaa 2875681 gtttgcatta aaagacattt gtaaaatact cctttgtctt ttgaagagct tccacaagct 2875741 tatcaatctc ttcctctgta ttatacagat aaaagcttgc tcttgcagta gcagttacat 2875801 ccagccattt catcagcggc tgcgcacaat ggtggccggc tctgactgcg attccctccg 2875861 catcaagcac agtcgccaca tcgtgcggat gaacatcatc aaggttaaat gtgacaagcc 2875921 cggcacgctc ttccggcccg taaaccgtta cgccgtcaag ctggcggaag cgttcaagcg 2875981 cataagctgc aagcttgtgc tcatggcggg aaatctcatc aagaccgatt tcttcgagaa 2876041 aatcaatggc ggcaccgagg ccgattgctc ctgcaataat cggcgtaccc gcttcgaatt 2876101 tccacggaag ctctttccaa gttgattcat aaagcccgac aaagtcgatc atttcaccgc 2876161 cgaattcggc aggctccatg ttttccagca gggctttctt tccgtacagc acaccaacac 2876221 cggtaggtcc gcacatttta tgggaagaaa gcgcaaagaa gtcgcaatcg agatcctgca 2876281 cgtcaatttt catgtgaggc gtgctttgtg caccgtccac cacaatgaca gccccattgt 2876341 catgagcgat tttcgccatt tctttaatcg ggttgaccgt gccgagaaca ttagatacat 2876401 gagacaccgc aacaattttt gtgttgcttg tgaccgtttc tctgacgtct tctaaagaaa 2876461 tcgttccgtc ttcctgcaac ggaatatatt ttaatgtggc gccagttgct tttacagcct 2876521 gctgccacgg aatgatattc gcatgatgct ccatgtaggt gatgaccact tcatcaccag 2876581 gtttcaggtt ggcgcgcgca tagcttaacg ccaccatatt cagtgatgtg gtcgtgcctt 2876641 ttgtgaaaat aatctcagcc attgacttcg cgttaataaa cttgcggact ttttcacgcg 2876701 ctccttcata accatctgtc gctctggttc caagtgtatg gacgccccgg tgaacattgg 2876761 aattgtattg gttataatac ttatccagtg tttcaatgac agcacgcggc ttctgggaag 2876821 tcgccgcgct gtcgagataa acgagatcat gtccgttcac ttgctgatga aggatcggga 2876881 actgttcacg aatatctgtg atattcatta cttcactttc ctttcgataa cagaaactaa 2876941 ttgtttctta acgccttcaa tcggaagttc atttactacc ggtgcaagga atccgtaaat 2877001 gactaagcgt tctgcttctt ctttcggaat tccgcggctc atcaggtagt aaagctgaat 2877061 agggtccaca cggccgacag atgccgcatg tcctgcagtt acatcgtctt cgtcaattaa 2877121 aagaataggg tttgcgtctc cgcgtgcttt ttcgctaagc atcagcacgc gtgattcttg 2877181 ctccgcattc gctttagaag cgccatgttc gattttgccg attccgttaa agatagaaga 2877241 agcggaatcc ttcatcacac cgtgcttcaa gatatagcct tcagaagctt taccgaaatg 2877301 gatgatttgt gttgtgaagt tttctgtttg ctctcctctt ccgacaacaa ccgttttcgt 2877361 atcgccgtat gtgccgtcac cgtaaaggtt tgttgtgttt tcggaaatcg tgtcgccatc 2877421 gttcatcagg ccgagagccc actcgatttt gctgtcgcgt ccgcgcgcag caccgcggcg 2877481 gttcacataa gttgtcacac cgcttgacag attatccacc gcaccgtatg tcacgctggc 2877541 attatcacct gtgatgacct cactgataat attgaagaca gcgtctttcg ggtttacagt 2877601 gctgatgtag ttttctacat atgttacaga gctgtggtct tcagccacaa tcagcacgtg 2877661 gttgaataga gctgtatcat tgctttcgtg gacataaaca gcctgaaccg gcgtctccac 2877721 ctgaacattt ttcggaacat aaaggaatgc tcctccgtta acaagagccg cgtgaagtgc 2877781 agttaactta tgttcgtcaa ccttcacgcc gtccttcata aagtatttct ccaccaagtc 2877841 gctgtgctcg cgtgcagcag tcagaatatc agtgaagatg acgcctttgt ctttcaattc 2877901 ttgagaaaga gaaagatgtg ccggcgtctg gtcacgctgt acgtataatg ttttatcttc 2877961 gttttcaatg tcgatcagcg cttttacttc atcagtcaaa tcttctaatg aagaaagcgg 2878021 ttcgttatcc actgtatgct tcgcgaaatt cgtgaagttc cagtttgtga tttttgtttt 2878081 gtcaggtttc ggcatcggca gatcctcagc ttgttcaaga gcctgtaagc gcaggttctt 2878141 cagccaggca ggttcttggt gcttttcgga aaagcttttg agatactcct gatctacgga 2878201 tagttttgta cctagtgtca tattaatccc cctaacgctt acgcttcttg gccaacagtt 2878261 tcgtcttcaa tgccaagttc ttgtttgatc cagtcataac cttctgcttc aagacgctgt 2878321 gcaagctctg caccgccgga ttttacaacg cggccttgca tcataacgtg aacaacatcc 2878381 ggagtgatgt agtttaacag gcgctgatag tgagtgatca tcaggcagcc gaagttttcg 2878441 ctgcgcattt tgttgatccc ttttgataca actttcaaag cgtcaatatc aaggcctgag 2878501 tcaatttcat caaggatggc gattttcggt tcaatcatca ttaattgaag gatttcgttg 2878561 cgttttttct ccccgcctga gaagccttcg ttaagatagc gctgagccat ttcagggtcc 2878621 atttcaagga actccatgtt ttcgtccatt ttgcggatga atttcatgag agaaatttca 2878681 tcgccttctt ctctgcgcgc gttgattgct gagcgaagga agtcggcatt tgtcacaccg 2878741 ctgatttcac ttgggtactg cattgcaagg aataagcctg cctgcgcacg ctcgtccact 2878801 tccatctcca gtacatcttt gccgtcaagc gtgatgctgc cttttgttac ttcatattta 2878861 ggatgcccca taatagcagc tgataaagtg gatttaccag ttccgttcgg gcccattact 2878921 gcgtggaatt ctccaccttt tatttcaagg tttacaccct ttaagatctc tttcccttcg 2878981 atttcaacgt gaagatcttt gatcgttaat gttgaagcag ccatatctat acctccaaaa 2879041 atatataatc attattctca ttttattctc attctaattt tataacaaat gaaaagtaaa 2879101 tacaactttt tatcgtgcct tgcacattcc tcaagtttaa caaagatcag cactttatta 2879161 aagcgattga aaaagaaaaa gagtggattc ccaccctttt ttaaaagatt gattttctca 2879221 ataagctccc gcagaaatcc gcttgctttt ttcataatca agctctctct gccgctctac 2879281 tttcattctt gtttccagcc ggcgtccata ttcctcgtat ccaattccgt gtgacagctg 2879341 catcgctttt tccatttctg acgtataatc gaggttcagt ctgtcctggc tgctgcaaat 2879401 aatgaatcaa tcccttcata tatttgcttt ttattgtacc agtgctgcgt tggatgccgc 2879461 aaaaacgatt tggcgtgaaa tagcggcaga tgagacgaaa gcatcctttc agaacaaatg 2879521 agaatggttt ttcggaatat tccttctctt aatgcgtggt gtttccgaat tcctcaatgc 2879581 actgttgaac gactgtcacg ccttggctga aagctgcgcc gcctccaaat gccgctgcca 2879641 cactgacggc ttcgagaatg ttttcttctg acgctccctg atcaagacag ccttttgtat 2879701 gatagatcat gcaatattcg tcctgagcat tgatggcaat tccgagggcg atcagctgtt 2879761 tttctctttc agtcagagaa ttcccggcaa agcactgttc agtaaattcg ttaaattttc 2879821 ttcccatcag cggcatcttt tgttcaaatg tgcctaaacc atgtttatat tgttttaacg 2879881 cgtcctgcat gcttcctctg tcttgattca aagaaaatcc ctccatctgt ttaacattcc 2879941 tttttattat gaacagcttt taggaaaata cgcgaaaaaa accccggaat tctcatccgg 2880001 ggtttcagtc ttattcagat acaggaagca cagctccgtc gtattttttc tcgatgaagt 2880061 ctttgatctt tttagagtga agaacttcca tcagcgcttt gatttttgca gaatcttctt 2880121 cgccttttct tactgcgatg atgttagcgt atgggttgtt tttcgttgat tctacttcaa 2880181 ttgcgtcttt tttaggattt aatttatttt ggatcgcata gtttacattg atgaagaccg 2880241 cgtctccttc tttgttttca tatgcttttg ccgttaattc aggcgctact tttttgaatt 2880301 caaggttttt cgggtttttc ttaatgtctt tcaatgttgc gtcaactgtt tccactttag 2880361 aatcaagagt gattaatcca gcgttttcaa gcattgcaag catacggcct tgttcagcaa 2880421 cgttgtttgt cagaatgatt gtcgcaccgt ctggaaggtc tttcagtgat ttgtatgttt 2880481 tagagtaaat accgaatggc tctaagtgaa cagcgccggc attcacaagt ttgtaatctg 2880541 tgttttcttt catttcttgc tcaaggtaag gaatgtgctg gaagtagttc gcgtccactt 2880601 ctttatcagc taaagcttta ttgtacattt tgtaatcact aagcactttc actttcagcg 2880661 tatagccttt ttctttcagc aatggttcag cttcttttaa aatttccgca tgcggtgttt 2880721 ttgttgccgc aacgacaatt tctttcttgc cggattcagc gccgttattc gaaccgcagg 2880781 cagccataac tcctgcaaat acaagcagta atgcacccaa aaatagcttt ttcaatgtaa 2880841 atcctccctt atcgtttgtc tataatattt gttattagat caccgatgat ttgaataata 2880901 aacacgatga ttaaaataaa cacagtagca acgaaggtaa catcagcgtt attagactga 2880961 tatccttcta cgtacgcaag gtttccaagg cctcctgaac caatggctcc ggcaattgcc 2881021 gttgaaccga ttaaagcgat ggctgtaacc gtaatgccag aaataagagc aggcattgat 2881081 tccggaatca gcactttgaa aataatcgta gacgttttcg cgcccattga tttagctgct 2881141 tcaatcacac ctttatccac ctcacgcagc gcgatttcaa caaggcgcgc gtaaaatggt 2881201 gccgagccga ttaccagcgc cggcaatgcg gcgtttggcc ctaagatcgt gccgactaaa 2881261 aatttcgtaa aacctaatag taaaataatt aaaataagga acggaatcga tctgaatatg 2881321 ttaacaacgg ctgcaatcac tgagttgacc gctttattct gccagaggct tcctttgctc 2881381 gtcagaaaga gcagcaagcc gaggatgacc ccgatgacaa aagcaaacag taaagaaatc 2881441 agcgtcatat aaagtgtttc atatgtcgcg ttccataatt cagttaaatc aacgttcggg 2881501 aagtattttt caaacattcg tgatcacctc tgctttcacc tgtttgtcat taatgaatcg 2881561 gatcacgttt tgcacttctt cctcgtcccc gtcaatgtgg atgaacagtg aaccgtaagc 2881621 cccatccttc gtctgcgaaa ttttcccttg cagaatattg acgctgacat tgaagtttct 2881681 gatcatctct gtaatcagag gctgttcagc tgactcaccg acaaatgtga gctgaaccat 2881741 ttttcctgat gctgtatcat caagaaggtg ctgaagcgtc tctttcgttt cttccggctc 2881801 tgtcacctgt tgaacaaatc gttttgtcat ttgttccttt ggatttttga agacatcgag 2881861 aacctcgcct tcttcgacca ccttgccgtt ttccatgacg gcgactctgt tgcagatttt 2881921 gcgtatgaca tgcatttcgt gcgtaatcag cacaatcgtc aaaccgagtc tttcattaat 2881981 atcggacaat agatccagaa ttgaatctgt cgtttgcgga tctaatgctg atgtcgcttc 2882041 gtcacaaaga agaaccttcg gattgtttgc aagcgctctg gcaattccga cacgctgctt 2882101 ctgaccgccg ctcagctggg acggataaga tttttctttt ccttctaaac ctaccagttt 2882161 aatcagttca ttggcgcgct tgatccgctc gctctttttc accccggcaa tttctaaagg 2882221 aaacatgata ttatctctga cagtccgcga ccaaagcaaa ttgaaatgct ggaaaatcat 2882281 actgatctca tggcgtgctt ttcttaaacc gcgtccattt acttcattaa tcttggttcc 2882341 cgccacttcc acggttcctg aggttggttt ctcaaggccg ttcagcagac ggattaagga 2882401 actcttacca gctccgctat atcctataat tccaaaaatc tcaccttttt taatggaaag 2882461 cgagacgttt tggacagcat tgacatctcc atgtttcgac ttgtaaactt ttgaaacatc 2882521 ctgaagattg atcaaagcaa tcacctgcct taacactatt ctaagaaatc ttccggtttt 2882581 ttctgcaaaa gaaaagcctt tctgcacact tgagcagaaa ggcttatata aaatgccttt 2882641 ctctcatctt tcaaagctga acgcttcgtg tgaattggca ccatttcaac agtgttgatg 2882701 gttgccgggc ttcatagggc acttccctcc acctctcttg ataagagaaa tatatagtct 2882761 ttttcgtccg gaaattctta atgtagaata gcacggcgaa tgattaaatg tcaataaaat 2882821 aaatgatgtc aacttttact attataataa tttattattt tttaattttt taaaatcctc 2882881 tgaaaaaatc catttgtcag ccagagaatg gcttccagct ttaacagggc cctgaatgac 2882941 ccctttactt tgaggcttcc gctctgaata aggtgctgaa gggaaatgtc tccgtgcaat 2883001 aaatcaataa tttccgtttg gtttccgtaa aaggtcaggt tggacgtttg gggcggagaa 2883061 acttttttca tttctccctg ttcgtttatt gagacggtta aggcttctgc ttctccttgg 2883121 aaggtaatga gcaatgttga ggcattcaaa aggggtttta aaaacagatg ctgatactca 2883181 tcttctaaaa cttccgcttt ctccatatgt acaacctcct atttgttggt catacataca 2883241 catttctctc tttgtcgcaa gaaccccttt ataaaacgaa cgacaatttc attggatatg 2883301 ctgagaaata tgtcataaat gggatgcgga agatgatttt tgtttgatca gctcatataa 2883361 ataagaaacg gaatgaaatg catatcctct ttcgaccatc tttccgcctt taaacagcag 2883421 aaaacaaggg acgctttcaa tttgatacgc ttttgcgaat gtcggagagt aattgacatt 2883481 gttttgatag aaggcgacat ccggcagcat ttctttcacc actgtcagca ttttgcttgc 2883541 aagctggcag gtgccgcaaa acggagtata taaatataga aggtacacat catcttcaat 2883601 gtgatcaagt tcgtgttctt ggagttcttt catgctatac acctcgggac tttctttcaa 2883661 gaaaaatagt atggacattc agattcgcac gcagcaatac agaagcgata tggtgcctgg 2883721 gcgcagccgc tacttcctta taggctctgt cgacatggag atggcaggct tcattaaatt 2883781 cacgcttcag ctgttttctc aatttctcac ctgattcatc agcatcaact aatatataga 2883841 cgtctttatc ataaagctcg tcagccaatt cctcgagcct cagctggctg attgttccgt 2883901 ttgtgcagat aatgcgcatc ggttcattca ggacgctttc gattttctct ttatctgatt 2883961 tcccctcgac aatcataacc ttttccagct catccatctt catcttgttc acctgccgcg 2884021 tcaaatttga aatgttcaga ttgtaaaaga aggcagtgaa attcaccgcc aacattaaca 2884081 ccagccgttt tcgtagtcac aatctacata ttttgcgtcg tctccagaga ccacatcggc 2884141 tgtcttataa aatttctcat tttcaaagga ataaccggac ttaagctcat attcattcat 2884201 gcttgtcatt tggccgatca tctcattatc atgatataac gagagccggc cattttgaaa 2884261 gcggcctgtc acgtcattgg tgacatcgag cttttgtttg tcgaaagcca tattggacac 2884321 ctcccataac gttagcgtgt ccaattgctt ttacggctat cctgttttag tcttcttgtg 2884381 tcatctcttc gtattgctct gctgtcatca gtttttcaat ttcagaagcg tcagatggct 2884441 caacgacgat catccatgct ttttcgtacg gagattcgtt gacgaattcc ggactgtcat 2884501 caagatcttc gtttacttcc acaaccgttc cgttaatcgg tgcataaagc tcagataccg 2884561 ttttaacgga ttcaacactg ccgaatggct cgtccgcttt gatttcagcg cccacttcag 2884621 gaagttcgac aaacacgatg tcgcctagtt cggactgggc aaaatgcgta attccgattc 2884681 tggctttttc tccttcaact tttacccact cgtgttctcc tgagtaacgc aaatcttttg 2884741 gtatgctcaa ttgaatccct ccatttttta cagcactaca ataagaagat accacacttt 2884801 tcaaaaaaaa tttacattaa gcccagtttt cttcaaattg gtcttcttta aatccgacag 2884861 tcactttttc gccgtctgtt gtaagcgggc gtttaattag cataccatct gaagccagca 2884921 gttcgagctg ttcgtcctct gacatatgat acagcttttc cttgagattg agctcgcggt 2884981 atttcatgcc gctcgtgttg aaaaatttct tgagatccag cccgcttttt tcataaagcg 2885041 cttttaattc ttctttgctt ggcggctgct cagcaatatg tatttcgttt atttctttcc 2885101 catgctcttc aagccacttc tttgctttgc ggcacgttcc gcatttaggg taccagtaaa 2885161 aagttaacga catcttcttc cccctcaata aaataatcga ggttatttta acacagtttg 2885221 ttttaaaaac ctaaaacagt gcttcttaaa aaagagctcc gcgcatgcgg agctcatggc 2885281 caatcagaca gtatatttct cagcctcaaa aatgcctgcc gccgcctcgc gttttttctg 2885341 aatcacgttt ttaggcgtta cgcgtgtcag cttgcgcaga gcggaaagca tcatgcggag 2885401 tgaatctcct tcttccattg cgataaggga ttcctttgca tgcgcttcga tttcgttaaa 2885461 ggcctcttga acgaaaattt ctgtgtacag caccttttgc gctgcttttt cagcgccttg 2885521 tgcggcaatg gccttttccg ttctgagcac ggctgattcc attgcgtata cattgctgac 2885581 gatatccgct acgttcacga gaatttcttg ctcacgatcg atcgcttttc cgtatttttg 2885641 cgcggctagg ccggcagcaa acaacgcaat ttttttggct tgcttgacga tatatttctc 2885701 ctgctctaag acgccgcttc caggctcttc aggcataagc atcatgagtt cttcctgcag 2885761 cgactgcgct ttttcgaata aaggcagctc gcctttaagc gcttttttca ggaaggtgct 2885821 tggcacgatt aaccggttga tttcgtttgt gccttcaaaa atccgattga tccttgaatc 2885881 cctataggcc ctttctactt cgtattcctg cataaagccg tagcctccat gaatctgcac 2885941 gccttcatca acgatataat caagcgtttc agagccgaat accttattca gagagcattc 2886001 gatggcgtat tccgcaatcg atttggcgat ttgccggccg tccttgagat cttcggccgt 2886061 gaactggctc atattgtctt caaacagccc gacggttctg tatacagagc tttccatcgc 2886121 atacagcctt gaggccattg tcccgatttt ttcctgtgtc aatgaaaaac cagcaatcgg 2886181 cgttttaaat tggcggcgct gatttgcgta tgccgcagac agctcgatga cgcgtttaga 2886241 tgcgccgatt gtgccaaccg ccagtttgta acggccgatg tttaaaatat taaaggcgat 2886301 gacatgccct ttgccgattt ctccgagcag gttttccttt ggcacttcag cttgatccag 2886361 aatgagggtt cttgtcgatg atcccttgat tcccattttc ttttcttccg gtcccgtgga 2886421 gacacccggg aactcttttt ctacaataaa ggctgaaaac ttgtcgccgt ctaccttagc 2886481 gtaaactaca aatacatcgg caaaagcaga gttggtaatc cactgttttt cccctgttaa 2886541 tacataatgg gttcctgctt cattcagcac agctgttgtt tttgctccaa gtgcatcaga 2886601 cccagagcca ggctcagtca gagcataagc ggcgatcttt tcgcctgaag cgagtccagg 2886661 caaatatttt ttcttttgtt cttctgaccc gaaaaagacg atcggcaagg aaccgatacc 2886721 gacatgcgcg ccataagaaa gagaaaagct tcccgcacgc gaaaatttct cagtgatgag 2886781 tgccgagctg attttatcaa ggccgagccc gccgtattct tccggcacat cggcgccaag 2886841 cagccctagt tcgcccgctt tcttcaacag tctgacagaa tgctcgaatt gatggttttc 2886901 gatatcatct atatgaggga gaacatcttg ctcgatgtaa tcctctgttg ttttcgcaat 2886961 cattttatgc tcgtcagtga aatcctccgg tgtatacatt tgatcgtatg tgacatcctc 2887021 gattaaaaat ccgccgcctt tttgtacgtc agccgctttt tttgccattt gtttttcccc 2887081 ctttagcata attcaaatac accggccgct cccattccgc cgccgataca catggtcacg 2887141 actccaaatt gctcgtttct ccgtttcatt tcatggatga gtgagagtgt aagctttgtg 2887201 cccgtacagc caagcgggtg tccaagcgcg attgcgcccc cgttgacatt cactttttct 2887261 tcatcaattc ccaattccct gattacttga atggcctgtg aggcaaaagc ttcattcagt 2887321 tcaaacaagc cgatgtcctg cagctgaagt ccggcaagct tcaaagcgcg cggaatcgct 2887381 tccaccggtc cgattcccat cacttccggc ggcacgccgc ctaccgcaaa ggagcggaat 2887441 ttcacaagcg gcgccaggcc aagagcatcg gctttttccc ggtccatcag catgacagcc 2887501 gccgctccgt cactcgtttg tgaggaattg cccgcagtca ccgtcccgtc aacggaaaag 2887561 gccgggcgca atgtcgataa gatgtctgca gtcgtttgcg ggcgaacacc ttcatcctga 2887621 gaaaacacaa actgtttttc cataggctta tggtcttctc cgatttctgt caccgtcact 2887681 tcgacgggta caatttcatc tttaaatttt ccttctgcaa gggctttagc ggcgttttga 2887741 tggctgcgaa cggcaaacgc gtcttgatcc tcacgggaga cgccgtattt tttcgcgact 2887801 tgctcggctg tgtgccccat gctcatataa tattccggtg ccttttctgc caaagcaagg 2887861 ttcggacggg taacatgccc catcatcgga acttgcgaca tggattctgc tccgccggcg 2887921 atcgctgtat cgtaggcgcc cagcataatt ttttctgctg catacgcaat agactgaagg 2887981 cctgaagagc aatagcggtt aactgtaatc gccggaaccg tgtacggcag gcccgcgagc 2888041 gcaccgatat ttctcgccat attaagcccc tgctccgctt caggtgttgc acagccgata 2888101 atcaagtcat caatattgcc ttcgtagccg cctgcccgtt tcagcgtttc ttttacacaa 2888161 atcgctccca aatcatccgg gcgaacggtg gccaacgatc ctttttttgc ttttccaacc 2888221 ggtgttcttg cacctgacac aatgactgcc tctttcataa gctccctcct aattccgtaa 2888281 aggtttacct ttcacaagca tatgctgcat tctcgcttga gattttgcct ctcctgacaa 2888341 actcaaaaac gcttctcttt cgatctccaa taaatactct tcatcaacct ctgtaccaaa 2888401 cggcactttt ccgcccgcaa tgacataagc gagttttttc gcgatcttaa aatcatgctc 2888461 agatatatag ccggacagct tcatctgctc agcgccaagc aagagtgccg cataaccggt 2888521 ttctcccggc accttgacct tttcttttac aggcggccgc cagccggtat cgtataaaga 2888581 tgcggccagc tgcttcgcat cgtataacag gtggtcttga ttcacgctga tctgatccgt 2888641 ttcttttaag atgttcatct cacgagcctc ttgagcggaa gcggacactt tcgccatcgc 2888701 gattgtttca aatgttttca ttgccgcatt catcggatca tggccgcggc gaagatggtt 2888761 gatgtacagc tctttgttac ctcctccgcc agggatgagg ccgacaccgg attccacaag 2888821 tcccatatag gcttcgcttg ccgcttgaat gcgcgccgcc ggcaggcatg cttccgttcc 2888881 tccgccgagc gtcatgccaa atggcgcggc gacgaccggt ttcgcactgt atttgatctt 2888941 catcatcgtc tcctgaaaac ggcggatcac aaaatcaact tccaaaaagt tgtcatcttg 2889001 gacttccatt aagatcatgg cgagattcgc gccgacgcag aaatttttcc cttgattgcc 2889061 gatgacaagc cccttgtaat tccgttctgt ttcctctaat cctttgtgga tcatttgaat 2889121 gatatcgagg ccgatcgcat tgcttttcga atgaaattca agaagggcca catcatctcc 2889181 aaggtcaatt aagcttgctc cgctgttttt cgcaatcacg ccttttgttt ctttaagtgc 2889241 ttgtaaatga attcgttttt tgttttcttt cacggctctg tattcgccgc ggtcataata 2889301 aaataccgtt ccgttctctt tgatgtagaa ggtttcattt cctttgtcca gcatctcttt 2889361 tatccagcca ggcatatctg ctccaagctg ctcaagcttt tccgctgact gcttgaggcc 2889421 gatggcgtcc cacatctcaa aaggtcccag ttcccagccg aatccccact tcatggcttg 2889481 gtcaatcgca tgaatatcat cggcaatctc gccaagcagc tcggctgagt aaagcagggt 2889541 ttgagaagtg atattccaca gcaaacggcc ggccctgtca tccgaataaa taagcgcttt 2889601 cattttggct tttgtccctt ttgcctgttt tgccgcttca agtgccggtg atttcatttt 2889661 tgtccgctcg ccgtaagtaa gcgtcactgg gtcaagctca taaatcgttt ttccttcttt 2889721 tttataaaag ccttggccgg ccttgcttcc gatccaccct ttttccagca tatcgttcat 2889781 gaagcttgga atgcgaaaca cttctttttc atcgccatca gctttgtcat acacatttcg 2889841 ggcaacgtgg gcgaatgtat cgaggccgac cacatcaagc gttctaaagg tggcgctttt 2889901 cggcctgccg atcagcggtc ctgtgatcga atcaacctcc ccgacctgat aaccgccttt 2889961 cagcatttct tggactgtca cgagaagccc gtaagtcccg atgcggtttg cgataaagtt 2890021 cggtgtgtcc tttgctgtaa caacgccttt cccgaggaca ttttctccga aagctgtcat 2890081 aaactttaaa atatcaggat ccgtttcctt aatcggaatg atctctagca gctttaaata 2890141 tcgtgcggga ttaaaaaaat gcgttccaag aaaatgggct ttaaaatcat ccgaccggcc 2890201 ttcagccatt tcctgcactg atatgccgga tgtgttgctt gagacgatgc ttccagtctt 2890261 tcgatgttca tccacaagag cgaaaatttt ctttttgact tcaaggtttt cgacaacgac 2890321 ctcaataatc caatctgctt ctttcagttt ttctgcatca tcctccagat tgccaggtgt 2890381 aatataggag gtatttttcg ctgatgtgag gggagcgggc ttttgtttca gcagtttttt 2890441 catcgcctgc cggctcagcc tgctgcgcac ctccgaactg tccttcgtca gccccttttt 2890501 ttcctcttcc tttgtcaaat cgttcggcac aatatctagc agcaggacag gaattccgat 2890561 gttagccaaa tgcgccgcta tcccggaacc cattaccccc gatcctaaaa cggctgcctt 2890621 ccgaatgtgt ttgtgcatga gatatccccc ttgaacattg aatgaatagt cattcatttt 2890681 ttgactaaaa aaaatgaaac ccgtttcttc tttcatctta aaagatttcc ggttcgactt 2890741 caatagctaa tttgttattt ttttgtatga agcctataaa agtcgggcaa cttaagcccg 2890801 gaggtgaagg gaatggtacg agagaaaaaa aatccgtctt cagcggcagt cagcgcggcg 2890861 agcgtaaagg gagatgccgg tccgactcag cattacggcg gcggaaaacg gacaagtcaa 2890921 aatcagcagt ataaaaaaca taacatggga caatcataat gcagctgctt cccacggctg 2890981 ctttcacttt ttcaaaattc cttttaacac aaacgctgca ttggcaggcc gttcggcaat 2891041 tcttctcata aagtagctga accagtccgt tccatatggg acatacacac gcattctgta 2891101 gccttccttg gcgagttcct tctgacgctc cggcctgatg ccgtatagca tttgaaactc 2891161 aaattgcgat gcggggattt gatgttcggc gacgagctgt ttcgtaaatg caatgatgtc 2891221 atcgtcatgt gtggcgacag ccgtgtagtt cccgcttaac aactgcagct ttattaagct 2891281 ctgaaaatga aggtccgtgc ctcttttgtc gggaaacgct acagccgcag attctttata 2891341 agcgcctttt acaagtctga gattcggctt taagtcccgc atctttctga tatcttctgc 2891401 cgcccggtac aaatacgcct gaatgaccgt gccgagcttc tcaaattcct gtttgcattg 2891461 cctgtaaata gaaagtgtct gttcataatg agaatagtct tccatatcaa tggtcacagc 2891521 aacatcatat tgcttcgcaa cggaaagaat ggcgcgcaaa tgagtaagag caagttcttc 2891581 tgaaagatcg agcccgattg aggtcagctt aagtgaaagc tctgaattca attgatgttc 2891641 ggcaatggct tgaatggctt tcttgcattc ctctgcgact tggtttgctt ctttttccga 2891701 agctgcatac tcgcctaaat aatcaattgt tgcacacaaa ccggatctgt ttagcctttt 2891761 gacggtctta accgccgatt caatcgtatc ccctgcgaca aaccttcgtg ctccaagccg 2891821 cgttccgtat gcttttgcga acttggtaag tgttttattt tgagataaga ataaaaacac 2891881 atgtctcaac atccgactcc ctcccgccgt catcttcaaa acacctgtat ataactccca 2891941 gtctgaagga aactataaaa tgaacagaaa ccaaaggagg atcacaatgg ataatcagca 2892001 gcaatctcaa atgccgcctt ccgttatttc gacaaaggat catttgtatc tcaatgacat 2892061 gctgaactgg aatttgctcg cgatgaaaaa agcgcatttc atggcgcagc agtgccagga 2892121 tcaaacgtta aagcaagaac tcgaccgcgt cggacacatg catcatgatc actatcaaag 2892181 aatattaaag cacctgcagc caggccagca gcagtccggc tacatccaat aaggaggcgc 2892241 cagaatgaat cagcaaaatc aaaaaatcag caacccgcag acacctgtac cgacaacatc 2892301 ggaaatgaat gacagagatt tcgtcaacga attgctgaca accgaaaaat acatgacaac 2892361 agcttattgc actgccttgc acgaattcag ccacgagtct ctttatcagg atattcaatc 2892421 catttttgat gagtcacaaa aagcgcaaag aaaactatat gatctcatgt tccaatatgg 2892481 atggtattct gttgaagcgg aggattcaca aaagctgcag cagtcctatc aaaaattcca 2892541 gcagaccatt cagcagcagt ctccttatca gcaataacaa cattagtaaa aaggatacga 2892601 tgttctttcg ggcatctatc ctttttttgt gtaaaatcag ttgacttttc atttacgctt 2892661 atttatattt aataagcatt aactattttg tcattaaaat atatatacag tgtatgtaac 2892721 agaggggaaa tgaatatgaa gagtgcggat cagttaatgt ccgatattca attatcgctt 2892781 caggcgctct ttcaaaagat acagcctgaa atgctggaaa gcatggagaa acaaggtgtc 2892841 accccagcgc agctgtttgt gctggccagc ctaaagaaac acggcagcct caaagtttct 2892901 gaaattgccg agcgtatgga ggtgaagcca agcgcggtga cgctgatggc agatcgcctt 2892961 gaacaaaaaa atcttatcgc cagaacacac aacacaaaag acaggcgagt gattgatctc 2893021 agtcttactg acgaaggaga cataaagttc gaggaggttt tggcgggcag aaaagccata 2893081 atggcgcgct atctttcctt tttgacggag gaggaaatgc tgcaggcggc gcatattaca 2893141 gcaaaactcg cacaagcagc agaaacggat gaaaagcaaa acatgaaaag aggaaacgga 2893201 tgaaaatgag taaagaaggc aaacaatcaa aacgaacgtt attaataaca ggcttaatta 2893261 ttgccatgtt tttttcagcc cttgacggta ccattgtcgg aacggccatg ccgaaaattg 2893321 tcggtgatct gggcggtttg agcatgatga cctggctgac aactgcatat ttgttaacat 2893381 caacaaccat tgttccaatt gccggtaaac tggctgattt attgggacgc cgcattgtct 2893441 atgtatcagg tttgattatt tttatggccg cttctgcttt gtgcggaatg gccaacaaca 2893501 tgacggaatt gattatcttc cgtggactgc agggcatcgg cggaggcatc atgatgccga 2893561 tggcgatgat tgtcatcggt gacttgttca caggaaaaca gcgtgctaaa ttccaaggtg 2893621 tctttggcgc aatttacggg ctggcttcag tgattgggcc gcaaatcggc ggctggattg 2893681 tagactcgtt aaactggaaa tgggttttct atattaacct gccagtcgga attattgcgg 2893741 ttatttttat tgccagggga ttacagggac gccagcagac tggtccgatc aacttcgata 2893801 tcgctggtat tttcacaatg attgtcggtg tggtcagcct cctgctcgcc ttaagctttg 2893861 gcggaaaaga ttatgcatgg gattcatggc agattcttgg gttgttcgct ctcgcactga 2893921 tcggcattgt cagctttatc atcgtagaat caaaagcaaa agagccaatc ctgccaatgt 2893981 atttatttaa aaacagaaca tttacatttc taaacttgat cggcttcttt atgagtatcg 2894041 gtatgtttgg cgccattacg tttgttcctt tctttatgca gggaattgtc ggtgtaagtg 2894101 cgtctgaatc gggtacaatt atgacaccga tgatgatttc tatgattatc acaagtatca 2894161 tcggcggaca gcttgtttat aaaattggga ttaaaccgca aatcattaca ggcatgctgg 2894221 ttatggccgg cggattcctg ctgttaacga cattggatct cgacacgagc aagcttgtcg 2894281 ctacatcttt tatggcgatt attggtctgg gaatgggtct tgttatgccg attctgacat 2894341 tggctttaca ggaaagcttt tcgaaggagg agcttggagt tgtcacttca tccagccaat 2894401 tcttccgttc tatcggcgga acattcggca ttaccatgct gggagccgta atgaatgcga 2894461 gatcaggaaa tctattaaca gataaattgg ttccatattt agactctctt ccggcacagg 2894521 caagctcgtt tgccgcccag ctaaagggta tgattgatac aaatccgcaa gggctgctgc 2894581 aatcactgtt cagtccggac gcggtcaaac aaatccctgc ggctttctca tcccatattg 2894641 tgccgatttt aaaaacatcg ttgatggatt cgctccacag cgtgttttat acgggcctga 2894701 tctttatcgc agtcggagcc gtattcacct tgttcttaaa acctatcaag ctatcaaata 2894761 agaaagcgga agaccaacaa gaaaaagaga aggcggcaaa agccgttgaa tcaccttccc 2894821 attaatagag caccccgcgg gtatcaatcc gcggggtttt ttattcaatc atctgggctc 2894881 ttccatttcc gaaagaccaa tcctcatcct gatttccggc cagcatgata aacacatctt 2894941 cttttcttac accaagctcg gaatgaatcc ggctcgcgat tgagcggtaa agtgcttttt 2895001 tctgttcagt tgttcttgac tgtttcagtg taaaatgaat gtatatcagt tcatcagtac 2895061 gctcgacttg gagataaaat ggatcataaa aaaattcgct tttttcatat tgtctgatga 2895121 cttggaaata gtcatcttcc ggcacattga tttcttcaat catcgattgg tggatagtcc 2895181 tgctcagttt ttgaagccac acttcgcttc ttcccgaccg taaatgaatc tgtacaaatg 2895241 gcatctcccc gcatcccttt ctttacagcg tctgtccgct gtcaattgtg ataatttggc 2895301 ctgtgagtga ttcctgttca attagtgaac aaatcaattt ggcaacatca tctggttcag 2895361 caatacactg cagcagcaaa gagccgatca tgcttttcat tttttcttcc cgtccggccc 2895421 accatctcgt tgccacagct cctggtgcta caccgctcac tctgatttca ggcgctaagg 2895481 cgtgggccaa tgatttcgtt aaaccgtgca ccgctgattt tgatactgcg taaggcattg 2895541 atgagccggc accagttatc cctgcgatgc tgccgacgtt tacgatcgcc ccgtccttgc 2895601 ttttcttcat gaacggaacc actgcccgcg cgcagaaaaa catccctttc acattgacgg 2895661 catacagctc atcctagacg tcttctgtcg cagcctcaag atcatccatt ggaatatgcc 2895721 gtgtaatgct ggcattgttg actaaaatat caaccgtgcc gtgtgtgttc acgattgctt 2895781 gaatcatatc ctgcacgtcg ctgtttttgg atacatctgc ttggatggcg aaggcttgcc 2895841 cgccagcttt ttgaatcatt tccactgttt cctccgcttc tgattgcgag cgtgaataat 2895901 tcaccgccac aatcgcccca cgctttgcca attccatact ggctgctttt ccgattcctg 2895961 tgccgccccc cgttacgaga gctattttgt tcaagacatt cattgccgcc actccttgct 2896021 gttgactaaa gtatatttct gattccattg taatccagct ttgatgttac gtataatgat 2896081 tgttaaagat actagatatc actcagattg atagtaaacg aacggaggag ttcaaaatgg 2896141 aaagcggaga tttacgtgtg tttcaaatgg tagctcgtga agggaccatt acgaaagcag 2896201 ccctgcagct tggctatgta caatcgaatg tcacggccag aattcaacaa ttggaagctg 2896261 agctgggtac cacactgttt ttgcgccata atcggggcat gacactttct gcaagcggaa 2896321 aattgctgct ggactacgca aataaaatta taggccttct tgatgaagcg tctaaagcgc 2896381 tctcatcctc cgcagaacca agcgggccgc ttatgatcgg ctgcactcag acaaccgccg 2896441 cggtaaggct tccaaagctt ctggcatctt attatgaaga acatccaaac gtccagctgt 2896501 ctttaacaac aggacatacg caatttctcc ttgataaagt tcttcgttat gaattggatg 2896561 gcgcgtttat cggatgcgaa tgccatcatc ctgagctcga atcctatcct gcgtttgagg 2896621 aagaaccagt agttgtttcg gctgcctccg tgcccgatgt tgaggaagcc atcacaaagc 2896681 cgattctcgt ttacagcaca ggctgttcgt atcgagaaac acttgaaaaa tggctgcgtt 2896741 ccgtcggtgt cacacagccg gtcattatgg aatttgggac gcttgaagca attatcggcg 2896801 gggttacagc aggtcttggc atctcgttgc tgccaagaac ggttgtgcag aaacatgaag 2896861 cagaaggatc aattcgattg tacccgctgc ctgaagctct cagccagatg aaaacagagt 2896921 ttattgttcg aaaagattcg tttatcagca gcgcgctgag aacctttatg gattccttta 2896981 cgccagttaa aacggctgaa tcacaaaaaa gcagtctgct ataatgaaca gactgctttt 2897041 tggctattgt ttgtttcgat gcgcttcatt taattcctta atatgctgaa tgatctcttt 2897101 aatgccctgc ttcgcgtcgg ggtatgtcgc attccaatgc ttagcgagcg gaggcatgct 2897161 tttggctata tgggtgtaca aaatccattg cttcacttct tcttttagct catcgtttgt 2897221 ttcaccaagc agaagctcag tatacttctc cagcaatcca tcaagctgct cctgaagttt 2897281 ttgttccatt ttccatcttc ctttcgaaaa aacagcaagg agctttctca attgaaagct 2897341 ccttcgctgc gttatttatc catgtgatgt gaaagccgct tcctggacaa tgcatctgcc 2897401 cctgccatga ggaatgcaaa gaggcgttcc gaagagcggg tcctgtgtaa cctgacagtt 2897461 catagaaaac acattttgca caagatcaca agtgatgacc tcttccggac ggccttctgc 2897521 ataaatccgt ttatctttta tggccacaag atgatgcgca tagcggcacg ccaagtttaa 2897581 gtcatggaga accataacaa tcgtccggtc ttccttttca ttcagctcaa acagcaaatc 2897641 aagaatttca atttgatgcg tcatgtctaa atacgtcgtc ggctcgtcaa gaaggatgat 2897701 atccgtttcc tgggcaagcg tcatcgcgat ccaagcccgc tggcgctgtc cgcctgacaa 2897761 agaatcaacg gcacggtcag ccatgtcctc aagctttgtt gctttaagcg ctctttcaac 2897821 tgcttcctca tcctcttttg accactgctt cagccagttt tggtaaggat atcttccttg 2897881 cttcaccagc tgatgcaccg tcagcccctc tggagccgaa ggaccttggg gcaggattgc 2897941 gagctctttt gcgacttcct tcgtcggaag cttggcaatc gctcttcctt ccagcagcac 2898001 tgaaccgcct ctcggcttca tcaggcgcgc taatgaacgt aaaagtgtcg attttccgca 2898061 gccattgctg ccaataaata cggtaatttc acctttggga attgttaaat tcaactcatc 2898121 aataataacg gcatccccgt atcctaagct cagcgtttct gtagaaattg cactcatacc 2898181 cataaccgct cctttttgct ggctttttag cagcactatg tattgcacgt tttctatata 2898241 catgctttta agtcaattgt catcaatgca aatgattccg atattcagcc atttgatatg 2898301 gtcatatatc cctcattgta gcagaaaaca ctgactttga aaatcatttt caattagttt 2898361 tatggacata attgacgttt atgggttttt tatcacaaga ttacttcttg atttctctga 2898421 tggagccgtc cttcagcttc aattttaaat cgatatgatc ataatgactg tccagattaa 2898481 atgctgccag cacactgtgt atcacttctg tttcagccat ttggtctgtc acggaaagct 2898541 cgctcaaaat cattttcatc tcatctaacg cttcttctcc ttcctgattg acaccggaga 2898601 gcttatcctg tatttccgct ttttcctgag tcccgttctt tgtatagatt ccttcataac 2898661 ggttatgctc accatccccg tagctcacac gaagcgaaaa attactgtag ggaacggact 2898721 tcagctgggt gacggctgta ttttctcctt ctgcctgatg ctggtcttca ttgaaacggc 2898781 agcccgcaat cagaaccact gcgagacata cagccccggc tgctctgatc aaatgcatat 2898841 gtttcccccc tgtaggattc catttatttt aggtatatcc agagaatgaa atcctcattc 2898901 agagaagaat tgaaaaagcc ggggcattta acgccacggc tttttcttta agattcggtc 2898961 atttgtaaaa aggtttcggc gtcacgcaca gccagcttga tggcattctc ccagaaatcg 2899021 cgctttgtga tgtcagcgcc caaatgcttc atcgccaaat cctccactgt catagaagcc 2899081 gtatcgcgca atagcgccat atacttctct tcgaatgtgt ctttttcttc aagcgccaac 2899141 gcgtaaatac caagagaaaa caggtagccg aatgtataag ggaaattgta aaacggcacc 2899201 ctcgtgatgt gaaaatgaag ctttgatgcc caaaaaagcg gatgatattc ttctaacgca 2899261 ttgcagtatg cctctctttg cgcctcttcc atcagctcat tcaagcggct ggccggtacc 2899321 actccccgct ttcgttcctc gtagaatctc gtttcaaata gaaatcttgc gtgaatgttc 2899381 atgaagaacg caacgcttct ttgcacttta tcctccagaa gaacaagctt ttcttccctc 2899441 gtctcggcct gctggacagt cgcgtccgcc actatcatct ctgcaaacgt tgaagctgtt 2899501 tctgcaacgt tcatggcgta ggaacggttt aacggcctga cgttgagcat tgcttcctga 2899561 tggaacgcgt gcccgagttc atgcgcaagg gtagagacat ttgaggcgct tcccgaaaat 2899621 gtcatgaaaa tccgggattc cccgctgtcc ggaaaactgg tgcaaaagcc gccgactctt 2899681 tttccgctcc tgtcttccgc ctcaatccag ccgtcccgaa acgctttttc agtgaatgag 2899741 gacagctttt tgccaaacgt tgaaaactgg ctggtaatga tatttgcggc ttcatcatac 2899801 gaatagacct ttccgtcaga accgatcggt gcctcgacat cgtaccagct gagtttttca 2899861 aggccgagca tggatgcttt ccggttcaaa aactgaacga acggcttctt gttttcagtg 2899921 atgacctgcc acatcgtatc aagtgtttct tttttcatcc tgttaatttg cagcggttcc 2899981 ttcaggacat tctcccagcc gcgcgcttta taggtttcaa gccggaatcc cgccaaatga 2900041 ttcagcgtgc tgctgaaaat atcttgcttg ctctcccaag cttggcggaa acgttcatat 2900101 actgtttttc tgacagtacg gtcttgatga tccatcatat tctccgcctg accgacagac 2900161 aattgcttgt tttcaccgtt ttcctcatac gggatcgtca ttttcccgac aaccatattg 2900221 tataagtcac tccaagcgtg atatccgtcc accgcaaggt ttccgatcag tttttcctta 2900281 ccggggctaa gcttttcggc aaccctctgt cttctttcat ttaatatgta agaaacatcg 2900341 cgcaatcccg gttttgttaa caattcattc cacacgtctt gattaatgtc cacaagttta 2900401 tgatctaatg taacgagcga cgattgaaaa tctgcggaaa gccgattcat gaggcctgat 2900461 gctctatagc cttttgatca ttgatattct gggcctggag gcaagcaaca aaagcgccgg 2900521 cctgctgaag cttgacggat gtctgttcga ataaatcaag caacgcggtc agcccttcag 2900581 cctcttcagg cgattcaggc acctgaaacg catcagtcct gtcttgaaat gcacgcagac 2900641 tttgtgacag cttctcaata taacctttga attcttccga ttggctcccg cccttaaaaa 2900701 atgaatcaag atcccatctt tggcctaccc cttgcagcgc catatcacaa aacccctttc 2900761 cttctttcgt tctattatag aacaattctg aattattgta taaaaatttc tattacaggc 2900821 gtcatttcgt gttcaggata gtacaatagc tgtagcagtt taataggagg gttaggatga 2900881 ataaaaaaat agccatcgtg acaggagcgt ccagcggctt cggtctgctg gcagctgtaa 2900941 agcttgcccg atcatttttc gtgatagcca catcaagaca gcctgaaaaa gcggaacagc 2901001 ttcgagaatt ggctgcagca cacaatgtgt ctgattctat tcacattaca gctctcgatg 2901061 tcaccgatga acaatctata gtctcattcg gaaaagctgt tagtgcttac gccccgatcg 2901121 atttactcgt taacaacgcc ggaacggctt atggaggatt tatcgaggat gtgccgatgg 2901181 aacatttcag acaacaattt gaaacgaatg tcttcggtgt gatccatgtg acaaaaaccg 2901241 tgctgcctta cataagaaag catggcggcg caaagattat aaacgtgagc agcatcagcg 2901301 gactgacagg attcccagcg ctgtcgccat atgtttcttc caagcatgca ttggaaggtt 2901361 tttctgaaag cctgcgtatc gagctgcttc cgttcggtat cgaaaccgct ttgatcgagc 2901421 cgggctcata caagacatcg atctggtcaa cgtcattatc aaattttatg tcggtgcctg 2901481 ctgacgattc agcctatcat caatactata aaaagatcct ttcctatgtt caaaaaaacg 2901541 gagaagaaag cggagatccc caagaggttg ccgacctcat ttatcaattg gcaacaaaac 2901601 agcacataaa gaatttgcga tacccgatcg gaaagggcat caagctcacc ctgctgttcc 2901661 gatcgctttt tccttggtct gcgtgggagt ctatcctgaa gaaaaagcta ttcagctgat 2901721 ctaaattata attattataa tttagtattg atttttattt agtatatgat ataattaagt 2901781 caacagatca caaggaggac gttatcttat gaaaactgaa aacgcaaaaa caaatcaaac 2901841 attagttgag aattcactga acacacaatt atcaaactgg tttcttttat actctaagct 2901901 ccaccgtttc cattggtatg tgaaagggcc tcatttcttt acattgcacg agaaatttga 2901961 agaactttat gaccatgcgg ctgaaacagt ggataccatc gctgagcgcc tgctggcgat 2902021 tggcggacag cctgttgcca cagtgaaaga atacactgag catgcatcta tcacagacgg 2902081 cggaaacgaa acatcagcat cagaaatggt acaagcattg gtaaacgact acaaacaaat 2902141 cagcagcgaa tctaaattcg tgatcggcct ggctgaagaa aatcaagaca atgcgacagc 2902201 ggacttgttt gtcggattaa ttgaagaagt tgaaaaacaa gtgtggatgc tttcctctta 2902261 tttagggtaa caaaaaagct gaaccttaat cgggttcagc tttttgtttt ttcttagctt 2902321 gaactgcttt ctgtctgctt ggtcagtgtt gcgttcaacg ttttcgtttt tccctttcgc 2902381 agcacttgga ttgttgtttt atctccgact tttaagtctt tgtaaaggat ctgacggata 2902441 tccgcactgc tttccacgtc tttaccgttt agtttgacaa tgacatcctc agatttaata 2902501 cctgcttttt ctgccggcga atttgcttga acttctttta cataaacacc tttgcccaat 2902561 tgatctccaa acaggccgag cgtattttcc tgataggttt caggaacttg tgacatgtca 2902621 atcatctgca cgcctaaaaa cggacggtcc accttcccgt tttgcagcag ctggtcaaca 2902681 atcggctcga catcattgct tgggatcgca aatccaagtg attccacgcc gctttcgctc 2902741 accttcaagc tgttgatgcc gatgacctgg ccgcttgcat tgattaatgg gcctccgctg 2902801 ttccccggat tgatcgctgc atcggtttgc agcacgttca tttccaccgt cccctgtgtt 2902861 gtatccacat caattgtccg gttcagtccg ctaatgatac cttgtgtcac tgtaccggaa 2902921 aactgctgtc cgagcgggtt accgatagcg attacctttt cgccagtgcg cagctgtgaa 2902981 gagtcaccaa agctcgccac tttttttaca ttcttgccgc tgatttccaa aactgccaaa 2903041 tcagtaatgg tatcgctgcc gacaagcttg gcagtttccg tttctccgtt gtatagcgta 2903101 acagtcagct tgttcgcgcc ttcaacgaca tggttgtttg taatgatata cgctttatcg 2903161 ctgtcttttt tgaaaataac acctgacccg gttccgcttt cactttctga gctggagcct 2903221 cctcccgtgc cgaatgtgtt attttgagag gtttggatat ttgagattcc gacaatcgta 2903281 ggctctaaat cctctaccat atcagcgatg tttgatgcgt tcgttatcgg cgccgttgta 2903341 aaattatcag actgcacctg tttatttgcg gaagcggttt cggtcgcctg attttggtct 2903401 gacggcagat aaggcgcgat gccaagcatg aggcccccgc cgataatacc gcctaaaatc 2903461 gggctcagcc atgcggctct ccgtttcttt tcttttttca cagccgtttc ttgcttttcc 2903521 atttctaaag cagaagccgt ttcctgccgt cccgcttcat acgacacagg cgcgtcaagc 2903581 aattcttgtt cagaatgtcc aatcagcttc tggttttctg tattctgctg ttctgtatgt 2903641 gaaggttcag tttgatgttg atcgttttgg ccatcacgtc gataatccat gttcttacac 2903701 tcctttaacg gttattcatt tatcgttaca tattcatcgc atgtacaagt tcaattgtcc 2903761 caataatgag gagaaaagca aagcaccaaa atagaatatg tttgatcatc ctacatcttc 2903821 ctcgctcttt ttctcttcct ttcttccctt aaccatatca taaacaaaca ttgtgggata 2903881 aaaatgaaaa gaatatgtga aattatgaaa attgcctgcc gtatgttaaa actagtttat 2903941 aatgacgttg aaaggatgtg aagagccttg tcatacacca tttatctagt tgaagatgag 2904001 gataacctga atgaactgct gacgaagtat ttagagaatg agggctggaa cattacatct 2904061 tttacgaaag gtgaagacgc cagaaagaaa atgacaccgt ctccccacct atggattctc 2904121 gatatcatgc tgccggatac cgacggctat acattaataa aagaaatcaa ggcgaaagat 2904181 cctgacgtgc cggtcatttt tatttccgcc cgagatgcgg atattgacag agtgcttggc 2904241 ttagagcttg gcagcaatga ctacatttca aagccgtttt tgccgcggga gctgattatc 2904301 cgtgtgcaaa agctgctgca gctcgtatat aaggaagctc ctcctgtcca aaaaaatgaa 2904361 attgccgtct cctcgtatcg ggtcgctgaa gacgcccgcg aggtctatga cgaaaacggg 2904421 aatatcatca atttgacgtc aaaggaattt gatctgctgc tattatttat ccatcataaa 2904481 gggcatccat actctcgtga ggatatcctc ctaaaagtgt ggggacatga ctacttcgga 2904541 acagaccggg tcgttgatga tctcgtccgg agactgcgca gaaagatgcc tgaattgaag 2904601 gtggagacga tttacggttt cggctacagg atgatgtcat catgaaaaac aagccgctcg 2904661 cgtttcagat atgggttgtc atatccggca tcctgttagc gatatcgatt ttactgcttg 2904721 tgttattttc aaacacgctg cgagattttt tcactaatga aacgtatacg acgattgaaa 2904781 atgagcagca tgttctgaca gagtaccgcc tgccaggttc gattgaaagg cgctattaca 2904841 gcgaggaagc gacggcgccg acaactgtcc gctccgtaca gcacgtgctc cttcctgaaa 2904901 atgaagaggc ttcttcagac aaggatttaa gcattctgtc atcttcattt atccacaagg 2904961 tgtacaagct ggctgataag caggaagcta aaaagaaacg ttacagcgcc gacgtcaatg 2905021 gagagaaagt gttttttgtc attaaaaagg gactttccgt caatggacaa tcagcgatga 2905081 tgctctctta cgcgcttgat tcttatcggg acgatttggc ctataccttg ttcaaacagc 2905141 ttctgtttat tatagctgtc gtcattttat taagctggat tccggctatt tggcttgcaa 2905201 agtatttatc aaggcctctt gtatcatttg aaaaacacgt caaacggatt tctgaacagg 2905261 attgggatga cccagtaaaa gtggaccgga aagatgaaat cggcaaattg ggccatacca 2905321 tcgaagagat gcgccaaaag cttgtgcaaa aggatgaaac agaaagaact ctattgcaaa 2905381 atatctctca tgatttaaaa acgccggtca tggtcatcag aggctataca caatcaatta 2905441 aagacgggat ttttcctaaa ggagaccttg aaaacactgt agatgttatt gaatgcgaag 2905501 ctcttaagct ggagaaaaaa ataaaggatt tattatattt aacgaagctg gattatttag 2905561 cgaagcaaaa agtgcagcac gacatgttca gtattgtgga agtgacagaa gaagtcatcg 2905621 aacgattgaa gtgggcgcgg aaagaactat cgtgggaaat tgatgtagaa gaggatattt 2905681 tgatgccggg cgatccggag caatggaaca aactcctcga aaacattttg gaaaatcaaa 2905741 tccgctatgc tgagacaaaa atagaaatca gcatgaaaca agatgatcga aatatcgtga 2905801 tcaccattaa aaatgacggt ccgcatattg aagatgagat gctctccagc ctctatgagc 2905861 cttttaataa agggaagaaa ggcgaattcg gcattggtct aagcatcgta aaacgaattt 2905921 taactcttca taaggcatct atctcaattg aaaatgacaa aacgggtgta acataccgca 2905981 tagcagtgcc aaaatagact gtagatgttt tgcagtctat ttttttatgt gaaagaatag 2906041 ccgttaaaat ctctgtaatt tgttttgagc ggctgtttgc attgatgaac ccattttttc 2906101 tctgacaagg tctgcttcgg atatttgact ttctccactt tgattcctct gtttcgcaag 2906161 cggctgatca tttcgtccaa ttctctcatt ctagattcac cctttcgctt gagctttgac 2906221 cattcggtca tctcaattta taatataaat aatacatgat aaaaaaacaa gttacaataa 2906281 ggttaatttt ataacagacg gtgtgactat atggtcatat cctagcaggc ctccgggctc 2906341 cgaaagggtg gaaccattga aggaaaaaga aaaactgatt attgaaacag ccttaaaact 2906401 atttgcccaa aaaggataca actcaacatc agtccaggaa atcgcaaaag aatgcaaaat 2906461 atctaaaggc gctttttata tttattttcc ttcgaaagaa gcgcttcttc tctctatgct 2906521 gaactactat tatgataaaa cgtttacccg aattttaaat attaaaacga agggcgacag 2906581 ccccagaacg gcttaccgta aacagctgac cgtcctctat gaaaacattc ttgaacacaa 2906641 agattttatc agcatgcagt tgaaggaggg ttctctgcct tacacagaag aagtggagca 2906701 atgcgcaaaa aaaatccgcc agtcctcact tcaatttcat atcgacagcc tgctgaacat 2906761 ctatggaaaa aaagcggaac cgtacactgc tgagctttgt tttttaatag agggcatcag 2906821 ccagatttac ctggaatgca tgattttgct cgggtacact gtgaagccgt ctcaattagc 2906881 tgatatcatt atgaatcgaa ttgatgatat ggtaaaaggc atgtctgaac gaaacgataa 2906941 gcctttcatc acattggaag aggcgagctc tttattcgga cctcttacgc acggacggcc 2907001 tgacccgctg actgaatcaa ttgtgaaaag cctacgtgac aaaattaaca gcttaaacac 2907061 aaactcctct cttgaattat cggagagctt ggacatactt gaagcagaaa tgaagaaaaa 2907121 aacaccgaag ctggcgatca taaaaggaat gattcataat ctgacggagt ctgaagctct 2907181 cgccaaagat gcggaacagc ttaaatattt attaaaacag caacatattt agaagaacgg 2907241 ctgcttaaaa agcagccgtt cttcctatta cgcctttggt tttaccatgt cttccggctt 2907301 aaccatttcg ttaaattgct cctctgtcag caattcaagc ttcaaagctg cttctttgag 2907361 cgtcaatccc tctttatggg caagcttggc gattttcgcc gcgttttcat aaccgatatg 2907421 cgggttcagc gccgtaacaa gcattaatga atttgacagg ttttcctgaa tggtttcttt 2907481 attaggctca ataccgacag cacatttatc atggaatgaa ttcatgccgt cactgagcag 2907541 ctgcacagat tgcaggaagt tgtaaataat aacaggctta aacacgttca gttcaaagtt 2907601 cccctgactc gccgcaaagc cgattgtcgc atcgttcccc atgatttgcg ctgcgatcat 2907661 tgttaacgct tcgctttgtg tcggattgac tttaccaggc ataatagagc ttcccggctc 2907721 attttcagga atgacgatct ccccgatgcc gcagcggggt ccgcttgcga gccatctgac 2907781 atcgttcgcg attttcatta agtcagccgc aagcgctttt aatgcgccat gcgcataagt 2907841 gatttcgtca tggcttgtca gcgcgtggaa tttattcggc gagctgctga acgtttggcc 2907901 ggtcagctta gtgatctctt ctgagacaag ctctccaaac tctgggtggg cgttgatacc 2907961 cgttccgaca gccgttccac caattgcaag cgcacgcatt ttatctgtcg cttccaaaat 2908021 catttccttc gaacggtcca gcatgtgaac ccatccgctg atttcctgtc cgagggtcag 2908081 tggcgtagca tcctgaagat gcgtgcgtcc gattttgaca atatcattgt atgcttttgc 2908141 tttttcatcc agtgtattgc gaagctgatc aagcgccggc acaagctgct cgtaaacagc 2908201 caaaacagcg gcaacatgca tcgcagtcgg gaatgtgtcg tttgagcttt ggcttcggtt 2908261 cacgtcatca tttggatgaa tcgtttgatc agagttcttc tcttttaata aagcagtcgc 2908321 acggttggct accacttcgt tcatgttcat attgctttgt gtgccgcttc cggtctgcca 2908381 tacgacaagc gggaagttgt catcgtactt gcctttgagc acatcatcac aaaccgctgc 2908441 aatcgcttct gctttttcag cgtccagatt gccgaggcgt ttattagcta gagcagtgct 2908501 tcgttttaaa attgcaaacg ccttcacaac acgcatcggc attttttcag aaccgatctt 2908561 aaagttctcc ttgcttcgct gtgtttgggc gccccaaaat ttatcagcag gaacttttac 2908621 ttctcccatg gtgtctcgtt caattctgta ttccatttat gtatccctcc ataacggttg 2908681 cttcaataga tcataattcg ccaatgacac aaaaaatcct ttttattttt cgatcttggc 2908741 agattttaat tttaattcaa gatatacgcg ggaatccttt gaatatttgt attttggatt 2908801 tgtcctgccg tactcctttg atgtataaga gacatcataa tgctgttcaa atgatctaat 2908861 gagctgttca atttcttctt gttttccagc tagccttacc tgtgccactt cgtatcctcc 2908921 gctttcataa aaaaacttac tccatgaaat actctaacac agtatatcat ttttttaaca 2908981 ggaaaagata acctctacta aggttttgga taagaggtga cctcattgga acaaacagag 2909041 tttaaggaat atatacacga taatttagca ttggtgctgc caaaattaaa agaaaacgat 2909101 gatctggtga aaaacaaaaa aatgcttgcg aacggactgg ttttttacta tctctatttc 2909161 agtgaaatga ctgatgagaa taaggtgtca gaagccatta aaactttgat taaagatgag 2909221 gagaccttaa cgcttgacca ggtcaaaaaa cgccttgacc agcttgacgc aagacctgtt 2909281 gaaactgcaa aaaaaacgat tgaatcgatt ctcaacggca attgtgctgt gtttatcaac 2909341 ggattggata aagcctatat tctgaccaca ggaaagaaaa aaacaagaag cctgacagag 2909401 ccgacaactg aaaaagtggt tcgcggccca aaagtagcgt ttgtagagga tattgataca 2909461 aatctcgctc tgatcagaca aagaacctct catccgaaat tgatcaccaa aaaaatcatg 2909521 atcggcgaaa acaagctgaa gcctgcagcc attatgtaca ttgaaggcaa agcaaaaaag 2909581 tccgtcataa aagaagtgaa ggcgcggctt aaaaatatcc agctggaaga tatccaggac 2909641 agcggaacgc tcgaggagct cattgaagat aataaatatt caccatttcc gcagatacaa 2909701 aatacggaaa gacctgacaa agtatcttca gccctgttta acggccgtgt ggcaattttg 2909761 gtcgacagtt caccatttgt gctgctggtg ccggtttctc tcggcatcct gatgcaatcc 2909821 ccggatgact actatgaacg ctggatttca gcatctctta tccggtcgct gcgctttgct 2909881 tctatcttta tcaccttgtt tttgtcatcg atttatataa cacttgtttc cttccatcag 2909941 gggctgctgc cgaccgcact cgccgtcacg atttcggcga acagggaaaa cgtgccgttc 2910001 cctccgatat ttgaagccct gctgatggaa gtcaccatcg agctgctaag ggaagccgga 2910061 ctgcgactcc ccaatccgct cggacagacg atcggcctcg ttgggggcgt agtcatcgga 2910121 caggctgctg tagaagcgaa tctcgtcagt tcgattttgg tcattgtcgt cagtgtcatt 2910181 gccctggcat cctttaccgt tcctcaatac ggaatgggtc tgtctttccg ggtgctgcgt 2910241 tttatttcga tgttttccgc cgctatttta gggctatacg gcattatttt atttatgctt 2910301 gtcgtttata cgcacttaac gagacaaacg agctttgggt ctccgtattt ttcgccaaac 2910361 ggattcttta gcctgaaaaa tacggatgac tccattatcc gtctcccaat taaaaacaaa 2910421 ccaaaagagg tgaataatcc aaatgagcca aaaacagact ccactgaaac ttaatacctt 2910481 tcaaggtatt tctattgttg caaatacaat gcttggggcc ggacttttaa cattgccgcg 2910541 agcgctgacc actaaggcta atacgcctga cggctggatc acgctgatat tagaaggttt 2910601 catttttatt ttcttcattt atttaaacac gctcattcag aaaaaacatc aatacccttc 2910661 actctttgaa tatttgaagg aagggcttgg gaaatggatc ggcagcatca tcggcctttt 2910721 gatctgcggc tatttcctcg gcgtagccag cttcgagaca cgggcaatgg ctgaaatggt 2910781 gaagtttttc ctgctggaga gaaccccaat tcaagtcatt attttaacgt ttatttgctg 2910841 cggcatttat ttaatggttg ggggcttaag cgatgtgtcg cggctgtttc ccttttattt 2910901 aacggtaacc attattattt tgctgattgt gttcgggatc agttttaaaa tttttgatat 2910961 caataatttg cgtcctgttt taggcgaagg ccttggaccc attgcaaact cccttaccgt 2911021 cgtttccatc tcttttttag gaatggaagt gatgctgttt cttcctgaac atatgaagaa 2911081 aaagaaatac acgttcagat atgcgtctct aggatttctg attccgatta tcttatatat 2911141 ccttacgtat attatcgttg tcggagcttt gaccgctccc gaggtgaaaa cgctgatttg 2911201 gccgactatt tctctctttc agtcctttga gcttaaaggc atatttattg aacggtttga 2911261 atccttttta ctggtggtct ggattatcca gtttttcacc acatttgtca tttacggata 2911321 ctttgccgct aacgggctaa agaagacatt tggattatcg actaaaacaa gcatggtgat 2911381 tatcggcata acggtctttt atttttctct ctggccggat gacgccaatc aagtcatgat 2911441 gtatagcgat tatcttggct atatttttgt ctccctgttt ctgcttccgt tcattctctt 2911501 tttcattgta gctctcaaga ggaggattac aacaaaatga aaatccggat tttatgtatg 2911561 tttatatgca ccctattgct gtccggatgc tgggacagtg agaatatcga ggaattaagc 2911621 ttagtgatcg gaatagggct agacaagcct gacgatgaaa atttagagct gacacagcaa 2911681 attctcgtgc cgaaaataat cagcgccaag gagggctctt catctgatcc gacacagctt 2911741 tctatcacaa agggtaaaac tgtccatcaa atgatgagaa cctctgcatt aaagcataag 2911801 cctacgtttt cacagcattt gcgtctcatt ctgctttcca aaagcgtgat tgcggatcaa 2911861 attggaatgg acgccattat taaccagttt gtcagagaca acggaacaag gaggagttcc 2911921 tacgtcttta tcaccaacgg ccgaactaag gatatattta acatgaatga tgaaggcgaa 2911981 cccgcatcca acgtgatata tgatctgaca gagaataata aggtgacgat cagaacgatg 2912041 gagccagtta cattggggga gatctcagaa cacttaacct ctgacgattc attcctcatc 2912101 cctcatgtcg gtaaggaaaa cggcaagctc gcgataaacg gagcctctat cataaaaaat 2912161 aaattatggc accgggacct caccccgatt gaggttcaaa atatcagctt attttcaggc 2912221 actgtcgagg gaggcgtcat tgacttgaag cgcgatggcc atctcttttc ttatgaagta 2912281 tattcaagca atcggaagat caagacggca tacaaggacg gaaagttcaa attcaccgtt 2912341 acccgcaata ttgaaggtcg tctatctgag gactggaatc ccaatgaaga ctcgtttaag 2912401 gattcatata ttaaaagtat tgaaaagaca gtcgaaaaac gagtacacga aacagtaacg 2912461 tcatttatta cagagaagct gcagaaagag atcaaagcgg acgtaaccgg gctgggaaac 2912521 gaggtcagaa ttcattatcc tcaaaagtgg aaaaagattt caagaaaatg ggatgatgat 2912581 tatttcagca atgcggaaat agactaccgg gtcaatgtga ttgtcagaga cttcggaacg 2912641 aaaggcgcaa acaaatagca gccgcctaat tcacgagatg atttcggtgt gcgtacaccg 2912701 ccgcctgcgt ccggtcactg acatccagct ttgataaaat attcgtaata tgtgttttga 2912761 ctgttttaat cgtaataaac agttcctcgc ctatttcttt gtttgtcttt ccttctgcga 2912821 tcaggcagag tatttcgagc tcccgttttg taagcgattc atgcgggagc gcgttttcac 2912881 ctgagtggcg cagcctggat aatacttttc ccgccacttt tgactccagc ttcggctctc 2912941 ccttgcttgc ggcgcggatg gcatcggcga tttctgccgc ttttgaggtt ttcaacagat 2913001 agctgagcgc gccagcttca ataaccgggt acactttgtc atcatcaatg aagctagtga 2913061 gcacaataat tttcgggtcg gaaagctccc ggcaaatttg ctttgtagct tcaatgccat 2913121 ccatgccctc catgacaagg tccattaaaa tgacatcagg cgacagttcc acagcaagcc 2913181 gaacaccttc gctgccgtcc gatgcttcgc cgatgacttc aatatcgggc tgcgcctcca 2913241 aaaaagccgc gagccccatt ctgaccattt catgatcatc aatcaataat actcgaatca 2913301 cgttcgttct ctcctttttc ttccggaaaa atcgggacct tcacttcgat ttgagtgcct 2913361 tttccttcta ctgaaatcac ttcggcgaca ccgccgattt cacttgcacg ttctttcata 2913421 gaattcaagc cgtatgagga ggctttcacc tggtccattt taaagccttt tccattatca 2913481 atcaccttca gacggagctg gctgttcttt atgcccagaa tcacggttac ttttgacgct 2913541 tttgaatgtc taaatacgtt tgaaagggcc tcctgcacga ttctgaacaa gtggtcttca 2913601 acacccttgg atatcgctgt gtcctgtata tcccactcaa tatcaatcgg ctgctttttt 2913661 cggaactcgt ccaaaagctc cgtaaggccc tccttcagcc cttttccttc aagggtaaca 2913721 ggccgtaaat ggagcagcag cgccctcatc tcattttggg cttcgcctgc catatgctcg 2913781 accatcctga tccgcttgac tgttttgtca tcagcatcct tgacatgttc cagcacggct 2913841 gatgtcatca tcgatatggc aaagagctgc tggctgaccg catcatgaag atctctggcc 2913901 aatcgctggc gttcttctga gataaccgac ttcttcattt gagcctgcca ttccgcacgt 2913961 tcattggaaa gtttctggag ggatgcgact tgaagctcca cgcgcttcgc catttcgttc 2914021 agctgatcag cagccaggcc gatttcatca tcaccgagcg gcggtatccg ataagcgaaa 2914081 ttgccgtttt caaaggttaa aatggattca attaatgtat caatccttgt cttcaaccgg 2914141 ttgccgtaca tataccctga ggcgaaaccg acggtcacgc tgatcagaag caaaatcagg 2914201 ataaacggaa ttccgaacca gcttgatgac agcaaaacaa gcggatcgag ccgatagtaa 2914261 aacatcataa aggaaatcag gcaaacaaaa aggagcaggc tgattcccgt tgtcatgcgg 2914321 atggcgcgcc attggaggct ggcaagcatt ttttttctca tacgtacttc acatccacat 2914381 caccgataaa taaggaaacg gacactttta cccggcgctt tgactcgcta aaatcagttg 2914441 acgcggcata taccttcgtg cttaatccgc ttttcttcga gccgatcaga ttaatgtctc 2914501 ctataaaaac agccgagctg acagccactt caaggtccga tggtacataa atatcaacgt 2914561 taccaatgac tccgctaatg acgattgtac tttctccctc gggaatcatc gctttagata 2914621 aatcgatttt gatatcaccg ataaaaccag agacatttaa atcgttcagg tcaaacggct 2914681 gcttcatcat ttgcagctca ccgataaaaa agctgcgcat gtcgggatgt tttacatctt 2914741 ttggcggctc atgatgttct tttttattga gattgacctg tttctcattc ggttcaaata 2914801 tcggcttccc tttgataagc ctgtagccgg cgtaaatcag aaatgcggca aacgcatagc 2914861 cgaataaatt aaaggtgatg ctgaagaggt ttttcaaaaa tagaaacgcg gcaaagatat 2914921 acatgacgga gccaagccaa tcacgggaat attttttaag gaaatagccg gcaatcagaa 2914981 aaaagagcgg ccaaaacagc agatcgccta ttccgataat ttgcaaaaac atactgatgc 2915041 cgaataaagc aatgatcaat ccgagaagct gtttttttgt cattcctggt gtccgcctcc 2915101 tttcttctgc ctagtgctac cgtatcgcta gatccccgct gtccgttttg atgtcgattg 2915161 gatgccggcc gcttccttgc gtgcctgtga tgtgatgctg ttctttatgt cctttatcag 2915221 caaatgaata cggcgaactg acgtcaccgc ttgctgataa agcattgact gcaaagctgc 2915281 cattttgggg aaggcttaca ttagcatcac cgcttgtcag cgtgacagat acgggaccgg 2915341 ttaccttttt caatacagca ttaaaatctc ctgaagtcat tttcacatca agagagcctg 2915401 atacatgaac cagatttgcg tcccctgaag ctaaatcaat gccggctgtt ttggagacgg 2915461 tatttgaaat ggaaacatcc cccgatgatg ccttcacttt cagatcttga atgcggacgt 2915521 ccgtcacgct cgtatttccg ctcgcagata ctgcgttcag cccggaaagc gcaagatggt 2915581 cattcccggc cacagacacg tcaccgcttg aggttcgtac tgccagatca cctttataat 2915641 catacggaag cctgacgata agagttgaac ggttaaatcc attcaaaaat tgaaattctt 2915701 tttcctttac ggtcagctcc agttttcttt tgttttcagt aacaaataac tttcctgagt 2915761 ctcctgaaat gcctgccgat atgtcacttc gttcttccgc tataatccgg acatccttgc 2915821 tatccgactc aatgaccatg ctgtcaatgt cccgcggcga tgcgctggct gaatcagctt 2915881 ctgtgccatt tatgaaacct aggcctgcag caaacacatc ttttacgacg acggcgaaaa 2915941 aaaccagaat accggcagtg atcaacagtt tgccaagcat ttttttcatt cggtttcatc 2916001 cttctcattc attctattat aaaggaaaag cttgcgaatt gatacgtgcg gaagggaagg 2916061 acttgaccgc aaatccttcc ccgttccgct tattcatttg ccgcttttgt ctggtctgat 2916121 ttttgcagtg aaagtgtccg cattttttca atctccgctt ccacatcgtc tgcgaattct 2916181 ttacgtgtaa gttctgtgcc ggcttccgct gactttgaat aattcgcgcg gatttccatt 2916241 tcttcaatac gattttcaat acgtaaaaat tcacgatacg cgctttcact gtcaattttg 2916301 tcaaatgtcg tattcatatg ctctttagct ttcgccgcat ttgcccgcgc aatcagcgcc 2916361 tgttttttat cctttacgtc ctgaagcttt gtttcaagtg cagccagctg ctctttcaga 2916421 tcagccagct gactgtttgc ctgttcatag gaagctttat gctcagccgc cttcccttct 2916481 aaatacttca tttcagtcag cgcctttttc gccagttctt cttcacctgc gtcaaatgcg 2916541 agctgtgcct gatttttccg tttgccagcc acttcagcgg cttcttcata ttttttctta 2916601 aattgatagg caatcgtgtg ctgtttcaca attgtttgct ttgcttttgc gatgtcgctt 2916661 tccatatcgc gtacatattg attcagcatc acctttggat tctccatttt atcaagtcct 2916721 tcatgaactg acgcaacaaa catgtctctg attcttttta ataccatacc tgattcctcc 2916781 taatatattg atattatttt ttcttcaaaa attcttccca ttcgtcatca aagtgagatt 2916841 ggtaggcagc agaagccggt tcaggatcaa aagatgatac accgttatca gctgatccgt 2916901 ttttcatcag cttccagccg taatacacca tagcggccgc caatgcgatt ccgacgacaa 2916961 acggaagtga gcagatgagc ataatggctc cgataccgcc cacgatgatt cccgtgatgg 2917021 tttttcccgc ggcaaacctt ttgattcctg cgtatgtcat caagctcccg atggcgagcg 2917081 ggatgataaa gccgaagctt cctcctccaa aaaagacgga gatcccaaat acaattaata 2917141 agaatccgcc tattgttttc ttgtttattt tcatgcagat cctcctttcg ttttccttgt 2917201 cttcatctta tacaagttgg aagatatgca aaacgaatca gagattgatt tttatataag 2917261 accggagtcg tatctcgcac cggacccatt ggcacaaaaa aacgccatgc acgaggcatg 2917321 gcgttttaaa accctttaca gatgaacact tgcttccctt tctttaatta ggtcggacct 2917381 ttctgctttg gccaattttg taaacagcaa gattccgata cccgcaataa tttcgacaat 2917441 cccaccgaca gcgatcactt tacctgagcc gaaagcatta gcggcatacc cgcaaatgac 2917501 agctccggca gggatcgaaa tatttgagat catatgtata acggcgtaaa cctgcggctg 2917561 atcctcacta tccacagacg tctggataat cgtgtactca ggaacattaa cagcactgac 2917621 tgcggcacca aaggtaaaag cagcgaaaaa gacgagcggc aaaaaggtat tcatcccggt 2917681 aataaagaaa gcaaatcctt caataatgcc ggcagtgacg aataacaagc cgtacctgtt 2917741 taccttgact ttcgccagca caaaccctaa taaaaacgcg cccgcggcgg tggtggcctt 2917801 taaaagcgag tatacgatcg gctggccgtt taaatcttcc gcaacgtata cggcagagag 2917861 cgcttcccat ggggcagccg cgaaattcat aaagatacag taaatggcga gcggatataa 2917921 aatctggtgt tttctgacga gcctaaagcc gcgtttcagt cttccgatat atgtgcctct 2917981 ctgtgtaaca accgcagact ctgattgaga ttcaaccgca gtgtacttaa taaaaagaac 2918041 gagaaaacct gacaccaaat agagcacaag tgcgataagc atggtataag aaggactaat 2918101 aaatgtaaga aaagcgccgc ataatgtgac agccccaagc cggacaattt gagcggagga 2918161 ttgcagcaca gcgtttgctt tttgaatgcc ctgttcattg acgatttgag gaatcaaagc 2918221 gatagaggcg ggattgtagg cagctccagt agctgaatgc acaatcataa gcgtcatgac 2918281 aaaccacagc ggagagaagc ccgcaaaatg acatagaggg ataatcaaaa caatcgccgc 2918341 ccttgtcaga tctgaaaagt acatccaaaa tttcagcgtg gtctgtttca taaaaggccc 2918401 cgtcacaggc gccagaacgg cttccggcaa aaacgtgaca gcaatcaata aagcagtgcc 2918461 gatcgcacct ttgccgtcat aaattaaaaa ccataatatt gaattaaatg cgaacatatc 2918521 gccggatatc ttgactattc ttgagaaaaa cagataattg aaatttctct tccagatgct 2918581 atcactttca attaaattca ccatccatca gagccccccg ttgcctattt tttacatcta 2918641 tttattacaa tatctcattt ttccattttt cagtcaataa ttcataaggt tcattttttg 2918701 tcgtaaaatg ggaaattgac agagtgaaaa acaaaaaaag ccggcatgta tttgaacacg 2918761 ccggctttcc ttttcacttt ttatgattcg ctgctgtttc ggtcccgaaa cacaatggca 2918821 cttctttcat attctacatc gccaataccg cttcttgcat tcacaacccg ggcggcggca 2918881 aagaaataat cggacagacg attgagataa cgcagcactg tttcatgaat ctcctccgat 2918941 ttcatcagcg ccaccactct tcgttctgcc cgccttgtaa tggtgcgtgc gatatggaga 2919001 agcgaagcac actttgatcc gcctggaaga ataaatttct tcagttccgg cgcttctgct 2919061 gtataggcat caatgcgcgt ttctaaaaag gaaacagatt cttccgttag tttatagtct 2919121 tttctttctg tgacgattgc cagatcgcct ccgcagtcaa acagctcatg ctggatggtc 2919181 agcagctcgg ctgtcagatc ttcaaagccg ggctgcccgg aaagctctgc caaagcaagc 2919241 ccgataaagc tgttaagctc gtcaatcgtg ccgtagcttt cgacgcgtag gctgtccttg 2919301 tccgttctgc ccccgactaa gcccgtttgt cccttatcgc ctgtttttgt atatagtttc 2919361 ataccctgaa tctcctttac agacttattc aaacaactca gcagcctctt ttatacattc 2919421 agctgtccct ttctttatca attggttcag ccgctgttct atgttttctg attgctgagt 2919481 ttgagtcgcg gcgatgagaa tatcacctgt gcctcctccg tctcccagca ctttcgtccg 2919541 ttctgcttcg gcagccataa gagctttgat gaagaattga tctgccgcat agccgttaat 2919601 caaaatccaa atcgaaaagc cggtctgaac gcatatgaaa acggataact ctccgtcttc 2919661 atatgttcga tacacgaaac ggtcaagtct ttctgaagaa gccatcgcac acgtctcctg 2919721 cagttgaaaa ccgctttctg aaagacaggc cgtaagtcct tctatcggat ctggctgatc 2919781 tggcagccgt ttatggatca gcgtcctgct ccacgaaaac cctgcaccga taggcgtgga 2919841 ggacaatgtt cgaagcggga tttccgtttg cagaagaatg tcatcacgcc ccgcttggag 2919901 caatgcttca aatgggatag actgccgctt cacgctatct ttttcaggct gaatcacaat 2919961 catcggttta ggtgagcttt gatgaaccaa ggcggtgaca tctgtatcgt acaccgcctt 2920021 tatgctttgt tctgtaacag catattccgg tttttgctta ggcccggcgg taccgttttt 2920081 cataaacatg agcccatcac agtacaggct tgcggtgttc agatcatgaa aaacgctgac 2920141 agctgccaat ccgctttctc tcgtcaggcg tttgatcaga tcaagcaggt ctttttgata 2920201 agccagatcg agaaaattag tcggctcgtc caaaaataaa atacgcggct gctgcgccaa 2920261 agcttgtgcc aaatacaccc gctgctgttc ccctccgctt agttcgcgaa tcggcttttg 2920321 cgcaaaatcg gccactcctg tttgctccat tgcttcctgt acaatggctt cacccttttc 2920381 agtctgctgt ctgaacagcc ccgtttggaa tggatatctg ccaaaggcta cagtttcttc 2920441 gacagtaaag gtgaaggctt gatccatttt ttgcggcagg acagccatga tttgcgccag 2920501 ttccttcggt ttatagtccg ccagcagttt tccggccaga taaaccctgc ctttcttggc 2920561 cggcagcgta cctgtcagca agtgcaaaag cgtggttttt ccgcttccat tagggccgag 2920621 aattccaaga aattctccct tctccactgt taagctgaca ttgttgatta ggcggctgtc 2920681 gccgtatcct cccgacagcc cttctgcctt catcataagc ttctcccccc gcgatgctgc 2920741 cgaattaaaa taagagcgaa cacaggcgct cccgccaagg acgtaatgat cccgatcggc 2920801 agttcaatcg gctcaatgat ggttctggaa agcagatcgg ctaaaacaag aaaccctgcc 2920861 ccaagcaagg cggacaacgg cagtaaatgc cgatggtccg ttccccacaa aagccttgtg 2920921 atatgcggaa tcacaaggcc gacaaagcca atcgtacccg atactgccac agcgcttccc 2920981 gtcaaaagag atccggctat taaaatcatc atcttcctct gctgaacgct gactccaaga 2921041 agctttgctt tatcttctcc atatgtcatc acgttcagtt cccttccgtt tataatcaat 2921101 aaaatggttc ccaaaagaaa aaacgggaga aacaaaataa catagctcca gcccctcatt 2921161 gagacgctgc caagcagcca atgcacaatc ggaagcaggt tgtctcctgt caaggcgatg 2921221 ataagagaaa taaatgcgcc taaaaaagag ttggtgatga caccggtcaa aatgagggtg 2921281 gaaacagaca tcgaagcatg aacgaggcgg ctgaagaaaa ggaccgccgc catcgtggcc 2921341 agtgccgcgg ctacactcaa aaccgggagt gtaaaccctc cgatgacagg aaggtgcaaa 2921401 cctaagaaca gagtcacaac agctccgact gaagcaccgg atgacacacc tagcgtatag 2921461 ggatcagcaa gcggattttt caacaatcct tgaaaagcgg cccctgcaat agaaagagcc 2921521 gcccccacaa gggcggccag cacaactctc ggcagtctga tattcatcat aatattagtg 2921581 tacatcggat catcagaacc gatagagccg ccgaaacctt gatgccaaaa gacacgaaaa 2921641 acagcgggaa taggaatatg caggctgccg caagaaattc ctaagatgat gctcacggct 2921701 aaaaatgaga aaccaatgat atatgcggca taacgattat tccttaaacg tatccgggta 2921761 aatgctttcc gcaagttctt cgaccccttc gatcagacgg ggaccggaac gtgtcacaag 2921821 atcagggtcc acatcatata cacgatgatg tttcacagca ttgatttcgc tccagccatc 2921881 gcgtttttcc acagctttcg ctttcacacc gtccgttgta acaattgcat caggattgag 2921941 ttttacgatc gcctcgtctg tcatttgcac ccatcctgtc tgatccgcag ctgcgttttt 2922001 agcatggatg acatttagca tttcattcat aaacgtatct tttccggttg tataaatgtc 2922061 aggatcagga gaaacctcga taaatacgct tttctcctcg tcttttgaaa tggttttcgc 2922121 tttttcttga atatccttta gatctgattt catgcttttc acgagctgat cggctttttt 2922181 ctccgccccg ccagcttctc cgatcatttc gattgatttg tacacctcgg agaatgattg 2922241 tgcatcattg acagtcagca ctgtaatgcc cgcgtccttc agctgtttga tggcatccgc 2922301 tgatgctgac atggaagact catgggccag aacgagatct ggttttagag aaatgacttt 2922361 ttcaacgttt acattcatat ctccgacttt ctcaaccttt ttgacttcct ttggataggt 2922421 atcgtttgtg gtgacaccga ccactttgtc accaaggccg agtgcgtatg taatttctgt 2922481 gttgctcggc attaatgaaa caatcttttt tggctctttt ttgatggtta catcttggtt 2922541 tgacgcatca tcaatggtga cagggaacac ttctgttttt tgttttgcct ttgaatcctt 2922601 ctgatccgca ggattgccgc agcctgccag cataacagca gccaacagaa gcgcagccca 2922661 tatcccggct cgttttttca taatcttttc ctcctaaacg aactaaaaaa gcatctctac 2922721 gacggtaaag atgctgtaaa caacacaaaa aagcctattg tttacacatc atctgtcctc 2922781 gcagaattcg tgctgatcaa acaggcaggt atcctggctc ttggcgcttg gccaattaca 2922841 gtggcgggac cgcaccggct tttaccggtt tcccttttaa gccggctgtt gttcacggac 2922901 cggcacctat ttgacattcg tatccgtttt tcggagtaat tatactatat gactgacagg 2922961 cttgtatatg tgtcctgaat gacttttccc catattgtgt atggaagcaa aatcctcgta 2923021 aacactaaat ttgatcttgt atacttaata ccatcatcta tcaaaaggaa tgattcttat 2923081 ggatttacag ctaaaagaaa aactcgtctt aatcaccggc tcgacgtccg gtatcgggaa 2923141 agccgccgca aaaagctttc tgcaagaggg tgcggcagtc attgtcaacg gacgcaaaca 2923201 ggagactgtc gatcgcacca ttgaagagct ttctggctat ggaacagtgc acggtgctgc 2923261 tgccgatttg tcaaaaacag atgaagcagc ggcttttatc gaaaaagtaa atgaaatcgg 2923321 tgatatcgat atccttgtca acaaccttgg tttcttcgag gtaaaagact tcgccgatgt 2923381 gacagatgaa gagtggaatc aatatttcga agtgaacgtg atgagcgccg ttcggacaag 2923441 ccgtcacttc cttccaaaaa tgcttgccaa aaacagcggc cgcattttaa atattgcaag 2923501 tgaagcaggc gtcaaaccgc tgccaacgat gattccatac tcaatgacaa aaacggcact 2923561 gatcagcctt tcaagaggaa tggctgaaat gacaaaaggc acaaatgtga cggtcaactc 2923621 agtgctcccg ggacctactt ggacagaggg cgtggcctcc tatatggaag gcgccgcaca 2923681 agcagccgga caggatacag atacatttat caaagactat ttcaaggtca atgagccaac 2923741 ctcacttatt cagcgatacg cgacagcaga agaagtcgcc aacacaatcg tattcctcgc 2923801 gtctgacgcc gcatccgcca ttaacggcac ggcacagcgt gtggaaggcg gcattatccg 2923861 ttctctgtag tataaaaaaa cgcatccgtg tttcggatgc gtttttttta tacgtctcca 2923921 gcaaatggta ccggctgata tccgcctgtt tccagttgtg ctgaaaacaa ccctccagcg 2923981 tgaggctgct cgtatctctc tttttctgtc atttgttctg ttgccgttgt aatgtaaagg 2924041 gtttttaagt ctctgccgcc gaacgcgcag cacgtgacat atttagccgg cacgctgatt 2924101 gaattgattt cttttttctg aaacgggtca atgtgaacaa cgcggctgcc gccaaacagc 2924161 gccacccaca gcatgccatt ttggtcaatt gtcatgccgt ccggcaatcc gtctgactga 2924221 tcaaaacgat agacaggttc tggattcgaa acatctccgc tttgaggatc atagctgtaa 2924281 cgtacaatct cctgggtcgg cgtgtcgatg taatacatca aattccgctc gcggtcccaa 2924341 tccaaaccgt ttgaggtgga gacttgatcc ttgattttga caagactgcc gtctagattc 2924401 aaacggtaca gcgacgcctg tttttgctcg ccttccatgc tcgtcgtccc cgcccaaagc 2924461 cttccgtacg ggtcacattt agcatcatta aatctcaggc tctcatgcat gtccttcggc 2924521 tgtttaattt tttccaagct gtcatcccga agatgataca ggtaaaaccc gtccttcatc 2924581 gtcataatca gttcatcctt tgaatatttc gcaagcgccg tcacaaagga tttgaatttg 2924641 attgatcggt tgattttttc ttcagggtca aagatgtgga gctcgctccc caggatatca 2924701 acccaatata agcggccgtt ctcttcatcc cataacgggc cttcaccaat cactgcccga 2924761 gtgtctgctt ccaatactgc atccatgtgt tacacctctt tagcttcagt ctatatattg 2924821 ttattcccgg caaagaggtg tccaaaccac ttgatgttta ttgtttttta aaaaggatgg 2924881 taatgaccgt tccaatgttc gttctgctgt tcacatggat cgttccgtta tgcagatgga 2924941 caagctcctt ggcaatcgcg agcccgagac ccgttccggc agttgaatct tttgtgttcg 2925001 tccctctgta gtagcggtta aacaaatggg tgatcgtttc ttcatccatt cctttcccat 2925061 tgtccttcac ttttaaagaa atatgatttt ttgtttgctc cagaatgact tgaatctctg 2925121 ttcctttgcc gttgtgcttc acggcattcc caaggaggtt ttctaatatg cgcctgaacc 2925181 acgcttcatc aagggcaaat tcaatatgct cttctttgga tacaaacgag atatcatagc 2925241 cttcagaaaa cggatttttc ttaaaatcct caatgacatt tttaaaaaac gggataaggc 2925301 tagtgagctt tctctcaata ggaagagcat catttttcag gcgatacgtt aaatttaagt 2925361 cttcaatcag cttagacatg tattcagatt tttctctgac aacctgcccc atttctttca 2925421 cttcttccgg cgaccagtca tactgcttcg actcgagcat catgctgtag ccgtaaatgc 2925481 tgctgagcgg tgtttttaag tcatgtgaca aaccggcaat ccattcttcc cttgtcgcct 2925541 ggattttttc tctgtttctt ttatcccttc tcagcgtttc agtcagctga tccattgatt 2925601 caaatatctc accgaagaag cggtacggct gtttgatttt tcccttttta tttttgctga 2925661 caggacggcc ttcccggttt ctgggctcct caagcttccc ttttgacaga ttgaccagcc 2925721 atctaatcgt gtgaaaaatc ggcagcccga atcggaacat ataccaaacg gtcatccaaa 2925781 tgatatacat gaacaaaacg gccatcacga gaaacatcgc ttttaataca accttcagga 2925841 atgatttgtt aaactcctga tcggttacat agactgggtt cggcaccgta gcgaccatcc 2925901 atctgtcttt attgaggatc ttaacggaaa tttcccgctt atagttccaa ggcttagagc 2925961 tgtatttaag cagctccagc tggttcatcg tttttctctc gctttttgtg ctgttgatgc 2926021 tgtcgagaat ctttccattg ctgtctaaca ggtaaatggc gccttttttc cgtttaatat 2926081 agtcgatggt actagactta tagtgcgcta gtgagtctat cttttgttca cgcttttcaa 2926141 cggaagtcag gagctgttca ctttttgatt tccagccgga caatagaaga tacgacttat 2926201 cttcaatatt gatggcccaa taattcagtt tatagttatg aagctttttg gttttataaa 2926261 tagacaaaag ctctttcttg gtataggtgc ccggcacgtc ttttggcacg ccgtaggaat 2926321 aatcagtgtt tccttccgaa tcaatgattt gcatccagcc gtgctgttta tcaacagatt 2926381 tcttcaggaa attatccact tcccatgtcc cgtcttcgtt tacatcgaga tatgcctcaa 2926441 gtgtgtcggt cgttgctttc gtcagccctg aattggattc cgcatcgcta aaacgggcgt 2926501 ctaaatagaa aaacgatgca acaagcataa ccgtaagcag caggatcaca atcagcatct 2926561 ggccgaaaaa gtgaaacaaa aacttccatc ttaacctcat gaccgcttgc cttcaggatt 2926621 tgggataaaa cgatagccga gacctcgaac ggttacaata tactccggat tgctcggatc 2926681 gcgctcaatc ttctccctaa gcttgcgaat atgaaccatg acggtgttgt tgtcaccgta 2926741 ggaaggatag ccccatactt tttcatatat ttgatctttg gaaagcacca cgttagggtg 2926801 ttcacaaaaa tactgcaaaa gctgcagaag ctgggctgaa caggcaacgg cttccccgcc 2926861 tacgatcaac tcggcatttt gcggagaaaa agtaaagtaa tcatatgtgt aggtttgatt 2926921 tgaactcgtt tctttcgatt gatatgtacg cttgagatgc gctctgatcc gcgccgctaa 2926981 ttccagcgga ttaaatggtt ttgtgatata gtcatcagct ccaaccgcaa agcccgataa 2927041 tttgtccgcg tcggatgatc ttgccgtcag gaaaaaaatc ggagcgtctg aatactctct 2927101 gatcaatgtg caggcttcaa aaccggacat tccgcccatc atgacatcca gcacaatcaa 2927161 gtcaacctta ttggccttca caacgggaat cgcttcttct gcgcttgccg catccagtat 2927221 atttcgataa ccttcttttt cgagaacgcg tttgatcatg tccacaatcg ctttctcatc 2927281 gtctacgatt aaaattgacg cattttccac ttttatgttc ctttctgtca ctgttttttt 2927341 catcttatca ttatatcgtt tatttatggt acatttttga atacattgga gccttggcaa 2927401 atcaaaacag caaaaaagga gcaaacaagc gctccctttt gatgtttttt catatgaaaa 2927461 tattatgagt tctcatctac catgtacaaa ataaactccc aaaaccccgg tacatcctga 2927521 cataaaagca tatcagcctt ttcaaacatt ttgatcttca gctcttgctc taaatcttct 2927581 ctttcttgat aggacgtatt gctgagtttt tttctgatca tcggtgaaaa gcatgcaatc 2927641 aggtgctcaa tgtcataagt ctcgtctttt tgtttctttt tttgttcaaa ctggccgtcc 2927701 acagcttact tttccccctt tttttgcgcc gctaactgct ttctgatatt ctccagcccc 2927761 tttttatgaa tgttggagat gttttgtcgg gactccccta atgaatctgc aatctcctgc 2927821 atcgtggcac cgtgaagata gactttcgtc agcacacttt tttgtttgtc agtcagcttc 2927881 tggatcgctt ggtagagctg gtaatcctgt acatgctggc tcaaatcatc ctgcctgtct 2927941 aaaaattctt caaatgcatc gctacctgtt tcggaagaaa gccgatctcc cgcctccgga 2928001 tgatcaaccg tcagtggata ccgtttttgg tttttgcgaa cccgcttatc aaaatcaata 2928061 gaaaagatgc gaatcattga attcatatac ttgacgatgc ggatttcttt ataaaattgc 2928121 ttaaatagct cgtccaatga tcttgcatct ttttcgttag ggctttccat tacgtttttg 2928181 aacaaacggt aatgctgagg attgctcaaa aaatgcttca cgatgggatg cttcattatc 2928241 tccttacatt ttgaccgtaa aagactttga tagtccatca aaccgcctcc ctactaaatt 2928301 aaatgaagga aagcaaaaaa aagtaaacta ctactttccg cctagtgtct tccaaaatac 2928361 tttgcagcag tttacgtttt atcggttttc ctcacttaca tacatgactg cagaaaaaga 2928421 agggaggtat tttcctatgg atcaggtttt tatagaggaa gtcgtaaaac agatcggcaa 2928481 tttggggttt cccgcgctga ttgcaatgta tctgctgacc cgattcgaaa agaagtttga 2928541 tcaactaata gaactaatga cagaactgaa agatcatgca aaaaaataat ttttcaatcg 2928601 aagttgactt ttcactggtt tttttcactt aacaaaacag aagggaaaac gaaaggcctt 2928661 tcaccttctc tttctgctat cacatttaaa tgtaaggagg aaacatttca tgaaaaaaca 2928721 aaatgacatt ccgcagccaa ttagaggaga caaaggagca acggtaaaaa tcccgcgcaa 2928781 tattgaaaga gaccggcaaa accctgatat gctcgttccg cctgaaaccg atcatggcac 2928841 cgtcagcaat atgaagtttt cattctctga tactcataac cgattagaaa aaggcggata 2928901 tgcccgggaa gtgacagtac gtgaattgcc gatttcagaa aaccttgcat ccgtaaatat 2928961 gcggctgaag ccaggcgcga ttcgcgagct tcactggcat aaagaagctg aatgggctta 2929021 tatgatttac ggaagtgcaa gagtcacaat tgtagatgaa aaagggcgca gctttattga 2929081 cgatgtaggt gaaggagacc tttggtactt cccgtcaggc ctgccgcact ccatccaagc 2929141 gctggaggag ggagctgagt tcctgctcgt gtttgacgat ggatcattct ctgaaaacag 2929201 cacgttccag ctgacagatt ggctggccca cactccaaaa gaagtcattg ctgcgaactt 2929261 cggcgtgaca aaagaagaga tttccaattt gcctggcaaa gaaaaatata tatttgaaaa 2929321 ccaacttcct ggcagtttaa aagatgatat tgtggaaggg ccgaatggcg aagtgcctta 2929381 tccatttact taccgccttc ttgaacaaga gccgatcgaa tctgagggag gaaaagtata 2929441 cattgcagat tcgacaaact tcaaagtgtc taaaaccatc gcatcagcgc tcgtaacagt 2929501 agaacccggc gccatgagag aactgcactg gcacccgaat acccacgaat ggcaatacta 2929561 catctccggt aaagctagaa tgaccgtttt tgcatctgac ggccatgcca gaacgtttaa 2929621 ttaccaagcc ggtgatgtcg gatatgtacc atttgcaatg ggtcattacg ttgaaaacat 2929681 cggggatgaa ccgcttgtct ttttagaaat cttcaaagac gaccattatg ctgatgtatc 2929741 tttaaaccaa tggcttgcca tgcttcctga aacatttgtt caagcgcacc ttgacttggg 2929801 caaagacttt actgatgtgc tttcaaaaga aaagcaccca gtagtgaaaa agaaatgcag 2929861 taaataaaag acttgcggct tgcagagagc actcgttctc tgcaagcctt cataaggagc 2929921 tgaaccagtg aaacatcaaa acccttcaaa acgcttattg cggctctcca taaagtactt 2929981 gctggccgca gcagcagtgg tgttgaccta ttttgctgtc atctatatat tgttttcttt 2930041 agcgggaacg agctaccgct cagcagctca tgtcctgctt tttgccgtgg tattccttgt 2930101 tctcggatta tgctttgaac catttgaacg gctgatgata catagcttta catttttcaa 2930161 gacaggaaaa cgtctattca ttctccttgc tggcatcgta cagctgctgt ttttgtggat 2930221 gactgctcat acaacagacc aattgatcag cgacatctgg ctgtccacca cagaagaaat 2930281 gattgtcgca gccgtttttt tgattttaga caaatgcaac tcggctcttc ccagctaaaa 2930341 aaagaacgca ttccaattgg atgcgttctt tttattcata gcgaagcgcg tctacaggct 2930401 gaagcttcga agccttgata gacggaagca agccgaagat aatgccgact gccattgaaa 2930461 agatgagtgc tccgacaaca gctggaatgg agacgataaa aggcatcgga aaaatgaccg 2930521 tcagcagctt ggcgatgccg aagcccgcca gcacaccgag tattccgcca atgcttgtca 2930581 gcacgacagc ctcggttaaa aattgaaata aaatcacacg ccgcttagca ccgagcgctt 2930641 tcttaattcc gatttccctc gtgcgctccg ttacggaaac gagcataatg ttcatgacgc 2930701 cgataccgcc caccaaaagt gaaatactgg cgataccgcc aagcagcaat gcaaatgact 2930761 gattaaagga ctccacttcc tgcgcgatct cctgaagatc cattacactg tactctgctt 2930821 tttccagctc agcttctgac agtccctgat ttaaaagatc tgcagccatt acacccgctt 2930881 cttggatatg ctcagaagaa tcagcctgca cggcaatctg cgttggcgcg tcaaatcctt 2930941 caataagcgg ccacactttt ttcggcacgt acaaaaccgg gttcgcatag tcgccttcaa 2931001 acatgctttc ctgttgattt ttttctttaa aaacacccac gaccttaaac ggcacaccat 2931061 tcatctcaat gcttttatgc agagcttctc cgtctggaaa cagttcatct ctgacagctt 2931121 cattgatcat cactacttgg tgtgtgctgt ttaaatcgtt ttccgtcagc tttctccctt 2931181 cggttattcg gattggaaac atgtcgaagt aatcatcgtc cactccatac acttggggat 2931241 acgaaacgtt agttaaatga aaaacgctcg cgccttctga caagtaatat aaggataatc 2931301 ctttgaccat cggatctgat ttgatcgcct ttactgtttc ttccgctaca ggcggcgcgg 2931361 acgcatacga cacctgaggg ccgccgctct cctcttctcc gccagacggc tggtagacaa 2931421 cattgatggc gttgtttccc atgccgatca tactttgctt taactgctca ctttggccct 2931481 tcagcattga aacaatcgcg atgattgccg ctatgccgat aatgacgcca agcattgtca 2931541 gaatcgatct taatttatga gagaaaatgg attgaaagga gattcgaata tgttcaagca 2931601 tggctgatat cccctctctc atctaatacc aactctccgt ctctgataaa aacggttctg 2931661 tcagcttttt tggcgacgtc cgggtcgtgg gttatcataa taatggtctt gccttcccga 2931721 tgcagttcag aaaacagtgc caaaatttgt tcacttgatt tggtatcaag cgccccggtc 2931781 ggttcatcag ctaaaataaa cctcggctga ttgacaaggg ccctcgctat cgccacccgc 2931841 tgcttttggc cgccggacag cttaggcggt ttgtaggaga ccctgtcttt taatccgact 2931901 ttttccagcg cttcatatgc ccgttgcctt ctctcttttt tcttcacttt attgtagatc 2931961 atcggcagct cgacattttg cagcgcggtg agacgcggca gcaaatgaaa agtttgaaac 2932021 acaaacccga ttgattcatt gcgaatttcg gctaaagccc cgtctttccc tttcaatata 2932081 tcgatctggt caagcgtata ggttcctgag gttggcctgt ccaaacagcc gataatattc 2932141 attaacgttg actttccaga accggaaggc cccataatag ctaaaaactc ccccgcctga 2932201 acggtcagat tgatatgttt caagattgga acttcttctt ttcccagctt gtacgacttc 2932261 gaaatattat tcagtgtcag cattgactgt aacctgcttt ccttccttga ccgcgggatc 2932321 aggatagatc acataatctt ccggcgtcag gccgctctta atttccacca tgtcattttc 2932381 atcagtctct ccgatttcaa caggctgctt aaccgctttg tgattctcat cagctttcca 2932441 tacgtacggt tcgccgtcat cctgaatgac catgtcggac ggcagcttga tcgtgtccgc 2932501 atcagcatta tcactcatca cttcgatgtt gacatgatag ccgacttcaa gacctttatg 2932561 gctgtctaat aaaatggtga aaggatagtt agaggactgg ggattcattt cttcatcagc 2932621 aaagctttct gattcttcac cctcgcctgc tcccgctgga agcttgccga tcgaggtgac 2932681 ctttcctttc cactcgccct caccgcctgt tttcagcgtg accctgactt tgctgccttt 2932741 tttgatcgtg tccattaaca gctcattgat ttggcttttg accagatatt tgcctgtcga 2932801 aacaatctgg atatacgggc ctgctgcctg gtcgcctgtt gcaccgtcag cgatatcctg 2932861 attgacgctt tgaacgattc cgtcatgctt gcttgtaatg acattggaac ctttgttttt 2932921 cgtcaggcca gccagttctt tttgatgctg cttcagttca agctggcttg ttttcaaatc 2932981 gaaattggtt tgatcaagtt catcttgaag ctggtttttc tcttcttttc ctgcaacttt 2933041 cagctttttt tccgtttccg ttattgattt ttgcaaacgg ttgatttgca gatttgtcat 2933101 ttcaatttgc aaattggctt gctccacttc atcagaatga tcctcgccct catactcaaa 2933161 aagcttatcg ccctttttaa cctgatcgcc ttctttgacg tatgtttttt taatgctgcc 2933221 tttttctgaa tctatgtata ctttctgctg tttctcaggt tcaacctttc cagaaaacgt 2933281 ttggcctgat tctgaatctc ctcccatgta taccgcgacc gattcagcat agggctccga 2933341 tgatacggca acttggttca tgtgagtaaa aaagtaaaaa ccgccagcgc cgatcccagc 2933401 caatacaagc acaccggcac atatcgcacc gccaataagc cattttttct tcttggacac 2933461 aacgatctcc tctttctgta aactatgtaa tattttcgaa acattctaac caatattatc 2933521 tattaattca aaaagacttg caatcctttt attgaaatga cggaatcaaa tagaaaaatt 2933581 gtattttcaa agccgaataa aaaaaatccc ggcttcaaac cgggattttt tcatacagta 2933641 actagctctt tttcattttt aatcaagtca tatgtcaagc atacaggttt atttgtacgg 2933701 ggatcagtca cgatttcggc atcaatctga aatacctgct tcaaaatgtc tggtgtcatg 2933761 acctccagag cagttccttc cttgatgacc gtgccttttt tgagcgcgat catataatga 2933821 gaaaaacgag ctgcatggtt aagatcatga atgaccatta aaatcgtccg cccttgctct 2933881 ttgttgagtc tgtcaagcag ctgcagaatt tcaagctgat gtgcaagatc aagatacgtt 2933941 gtaggttcat ccagcagaag cagttccgtc ccttgcgcaa gcgccatggc aatccacaca 2934001 cgttgacgct gtccgcctga caatgcctca atcggccgtt cagcatattc agccatgcct 2934061 gtttcttcaa gcgcccattt gataatccgg cggtcttcgt catttaatct gccgaatcct 2934121 gattgatgcg gaaacctgcc gtacgacacc aattcgtgca ctgttaggcc gctcggcgct 2934181 tcaggtgtct gtggaagaat cgccatatct tttgcaatgt cctttgtaga cattttatga 2934241 atcgctttgc cgtttaaata gacggcacct gcatgtgaac gcataattct ggacattgtt 2934301 tttaaaatcg ttgatttccc gcagccgttc gggccaatta aggtggtaat tttcccttta 2934361 ggaatcgata tatttaaatc ctctacaatc accctgtcgc cataaccgat tccaagctgt 2934421 tccgttgata atgaattcat attcggcccc ctcctctaat tcgctttcat caataaataa 2934481 ataaagtaag gcgcacctag cacggaaatg acaagtccga ccggaatttc tgatggtgcc 2934541 aatacatttc tcgccagcgt atcagcaagc aaaaacagga atgagccgat gaaggcggag 2934601 accggtatca gcgtctggtg acgtggaccg gtcagccttc tagccacatg cggcgcgatc 2934661 aatccgagaa acgcaatgcc ccccgcagct gccacgcatg aagcggcaag agtgaccgct 2934721 gccagaagaa gaatccgtct ttccttttca acagcggtgc ccagcccggt cgccaattgg 2934781 tctccgagct gcataatgtt caaatagcgt gccttatata aagtaaacag aagcaagatc 2934841 acaatccaag ggagaatcgc ccagatcata ttccagttcg ccccccatat tgagccggat 2934901 atccaaaccg cggcttgcat aaaatcatga gggtccatct tgagctgaaa aatcagcaac 2934961 agggcgttga atccggcatt cacccctatg ccgactaaaa tcagccgaat cggtgtcacg 2935021 ccttttttcc atgccagaat ataaatgaga aacgcagcga ggattgctcc tgccaaagca 2935081 ctgaacggca gcataaatgt tccgaaaaag ctaagatctg aagctgaccc ttgaaaaaag 2935141 tatataaaaa gcactacagc aagtgaaccg ccggcgttaa ttccgagaat accaggctcg 2935201 gcaagttcat tttgagacac gctttgcaaa atggctccag ctacggagat ccctgctcca 2935261 acaagcaaag aaaggatgat ccggggcagc ctgaactcaa ataagacaag ttcatcacgc 2935321 gccgttcctt ggccgaaaaa gacctgaagc gttttaagcg gtgcaatttt gataacgccc 2935381 aaattgagac tgataaaaaa gaccaccacg ataagcaaaa aggtcacagc cattacaatg 2935441 agcggtttgt ttgtttttgt tttcattaca gccctctcct ttcacgacgt gccaaataaa 2935501 agaaaaaggg aacgccgata agagaagtca gcgcgccgac aggcgtttca aagggcgcat 2935561 ttacgagtct ggccgctatg tcagcaaaaa caagcaaaac agcaccgagc accgccgagc 2935621 aaggaatgat ccaccgataa tccacaccga ccaaaaaacg ggtaatatgc ggaatgatca 2935681 gcccgataaa tgcaatggtg ccggcaatgg aaaccgcagc tccggtcaga attactacaa 2935741 taagcatgcc aaccagtttc accgctgatg tatattgtcc aagccctttt gccagatcgt 2935801 caccgagact taacactgta acagaccggg cgatgaaaaa cgcgagcgtt aaaccgacag 2935861 cccctgcaat aagcaaaagc tggacccccg accatttcac acccgctacc ccgcctgcgt 2935921 accaaaagct gatatcctga gcgacatcaa agcggattgc aatggcagtt gaaatgccgg 2935981 taaagaaata agtaactgcc gtacccgcca gagcaagctt tacaggcgta agtccgcccc 2936041 ttgaaaacat gcctatgccc attaccgtcg atgcccccag ccccgctccc gcaaaggacc 2936101 atagcacaag ccccattgca gaaagtccgg gaaaaaaggc aaacgcaatc gaaaccgcaa 2936161 acgcagagcc tgatgtcaca cccataatcg aaggctctgc caaagggttt ctcgtcatcc 2936221 cctgcatgat tgctcccgac actgccaaca atgcgcctac aagcgcggca gccgccgttc 2936281 tcggaagccg aagatcatgt ataatttggt gagatgtctt tgtcggctga taatgaaaaa 2936341 tggcctccca tacagtgcgc aaatgaatat ccgctgcacc tagggatatg gataaaaatg 2936401 cgccaaggca aagcaggcat agacctgcga taaggacgat gaccgcgcca tatgtccttg 2936461 acgtccattg gatttcttct gatgcagtcc gtatattttt atgttgactc aactgccgta 2936521 cttcctttct gttactgata atgattatca attgctgttt cagtatatca cttttttcag 2936581 ctgatttaat agagtgtttt gaacaaaaat gaaaatgcat ttgcaaaaat atcgtgtcaa 2936641 ccggcacttg cagtggtata atcacagatg ataatgattc tctttttcat ctatctttta 2936701 gaaagaaggt atgagatatg acccatatat acaagaaact cggagccgcg ttttttgccc 2936761 tgttattgat tgcagcgctg gcagcctgcg ggaataactc agaaagcaaa ggttctgcct 2936821 ctgattcaaa aggcgcagaa acctttacat acaaggctga aaacggaaat gtaaaaatcc 2936881 cgaagcatcc taaacgggtg gttgtcatgg cagacggcta ttacggctac ttcaaaacac 2936941 tcggcatcaa cgttgtaggt gcgcctgaga atgtatttaa aaacccttac tacaaaggaa 2937001 aaaccaacgg cgtcgaaaac atcggagacg gcacttcggt tgaaaaggtc attgatttga 2937061 accctgacct gattatcgtc tggacaacac agggcgctga tattaaaaag cttgaaaaaa 2937121 ttgcgccgac tgtcgcagta aaatacgata agctcgacaa catcgaacag ctgaaagaat 2937181 ttgcaaaaat gacgggaact gaagataaag ctgaaaaatg gctggccaag tgggataaaa 2937241 aagttgcggc cgctaaaaca aaaatcaaaa aagcggtcgg tgacaaaacc atttccatta 2937301 tgcaaacgaa cggaaaagac atttacgtat ttggtaaaga ctttggaaga ggcggaagca 2937361 tcatttacaa agacctcggc ctgcaggcta caaagctgac aaaagaaaaa gccattgacc 2937421 aggggccagg ttatacaagt atttcattag agaagctccc tgacttcgcc ggagattaca 2937481 ttttcgcggg cccatggcaa tcaggcggtg atgatggcgg cgtttttgaa agctccattt 2937541 ggaagaacct gaatgccgtt aaaaatggcc atgtatacaa gatggatccg atcggattct 2937601 atttcacaga cccgatttca ttagaaggac aactggagtt tattacggaa agcttgacta 2937661 aataaacaaa agagccgcct gcccgcggct cttttgctta tttataagga acggctcaat 2937721 ttgaatcata tcggatattt tctttgagcc attcatatta agctgcatcc tcatcacgat 2937781 cagttttttt atgctggaga gactgaaaaa cgttttttgc atatttaacg aacggattcc 2937841 taacaggaga aattgtgatt ttataaaaaa gacacctgag caaatcaggt gtcttttcat 2937901 tatgcttgtt tttctttctg gaacttgtta ctcacaaatg gataaacgat taagccgaca 2937961 aagaataaac cgatgccgag tataaatgtc gttaaatctg ctgtgcctgt tacgataaca 2938021 aacacggagt atgcacacgc cagtatcgcg atcaatccgt ctcttacacg ggagcctttc 2938081 agctggtcat acgtttcacc tttgatgact accttcaagc tgtagattgc agataccaga 2938141 tacggaatta aatatgcgag tgtagccgct gtcgttaaaa atgtaaatgc gtcacttatt 2938201 gtccgggaaa taaccgagaa aatgaagacc tgtgacatga cgtttgtaat aatgagtgca 2938261 atgaccggac ttcccttttt attcgttttt gcaaaaaatg ccgggaaatc tcctgcttta 2938321 gcggcttggt atggcacctc agagccaagc aaaatccagc cgagcatcgt tccgaataaa 2938381 caaaggatag ccaaaagcgc cataatcacg cttcccgcgt ttccaacaat cgcatagagt 2938441 acatcaacaa atggtttttc agagccgaca agcttatcat gcggcagaac acccatcgta 2938501 attaaagtca caataatata tatgctcaag gcaatcagca agccggtaat tgtcgcacgt 2938561 ttcacatcac gctgagagcg cgcacggccg gacaggatca ccgcggattc aattccgaca 2938621 aacgcccaca gtgtagaaat cgcagcgtta tgaacctggc caccaattcc aatgcttgtg 2938681 ccgttttctc cttgaaccgg gaaataaaaa tgaccgaata atgacgtttg aaacacaaac 2938741 aaaccggcaa cgataaagaa gacaaaacct aatactttag aaagcgttgt gacaaagttt 2938801 aatttacttg cgccgttaat gctggcaaca agaatcgcgt gcgttcccca taacaagatc 2938861 gtacatacgg caaacgtcag taattggccg agtgtcacct cttgcccgcc gatcgaaaac 2938921 atctcacgtt tatcaaccaa gatcgggaag aacgaagtca agtaaccggc gagacttgtg 2938981 atgatcgcca cgttactgat ccagctcgcc acccagtagc cccacaccat tgtgaaaccg 2939041 gcagcgttgc cttttttcgg gtcagaaaac agcgctcttg cataactttg cggtcccgct 2939101 gtcagttcag gcttgcgaat ggacaagtgt ccgaacacaa gtgcaatcat cagcacgccg 2939161 gcacctgtca aaagccaggc ggacgtagct ccaaacggac tcgcaattga agcaagcgag 2939221 ctcggcaagg agaaaattcc tgatccaacc atatttccaa cgacaaacgc cgttaataac 2939281 caaaaacccc atttttttgt ctgttccatt ccagtacctc catgattctt tgtacggacc 2939341 agaccccgag atcatataaa cgcaaaaaaa gcctgaacaa aagtccatgc ttaaagaaac 2939401 acacaccctt gatctccgga tagccctccg cgaaaaagca cgcggcagtc ctgcacttat 2939461 tcagatacag tcccagcata gagaaggatc ggctttctcc acacttcggc gctgatgcct 2939521 tttacacatg tttaacagcc cctgtcagcc tagcatgtgt gactcatcat ccgcgcaacc 2939581 tctacctcac tgagaaagag tgaggattta attattcagt tactcccaga aggttatcaa 2939641 agaaaggatg atctgtcaaa gggaacagat ggaaaatacg gatagagcca agccctatcc 2939701 gcatgtggtt atcgattatt tttctttttt tgcacagctt cttgaagcgg atcatctttt 2939761 agagctgaac cagcatcttc aagagctcct tggattacgt ttttttcttt ttcggaacgt 2939821 tttcctttat ctttattaaa gaaacccatt cgtatcacct cttttaaaaa ataggtacat 2939881 gtttaagatg cctttttcct gaaaaattat gcgggatatt ttttatcgtc caaagtcctg 2939941 ttgatcaaac atacattctc ttgatatatt tgtaattcag agattttttg caaaagataa 2940001 aaggagaagc ggcaaatgac aggaaaaaca cacatcatgg gaggcatcgc ttcttgtacg 2940061 gcagcggctt attattatgg atttgatcca gtgcttatgg ctgcgtcagg cgcggttgga 2940121 gcattaatac ccgatatctg ccacacacaa agcaaaatcg ggagaaaatt tcctatttta 2940181 tcgaaagtgg tcagctccgt ttttggccat cgcaccttta cacacagcct gctgtttatg 2940241 ctcatcatgt tttttatcac ttctacatac attccagata aaaacatatc agccggcctg 2940301 atgatcggaa tggcgagcca cttgattctt gacgcttgga cggtgaacgg aatcaaatta 2940361 ttattccctt ccacgatccg cgttcggctt ccattatata tgaagacagg cagtttttct 2940421 gagcagctcg tgctagccgg cctgaccctt gcttcatgtt actactttta tatgctgttt 2940481 catggccgca tgttttaaac atgagtgctg agacttgtct gaaccggctg tttttagtag 2940541 gttttactta agaagcattt catgcagatg atcaagaaaa cgtgaggagt catattgatg 2940601 aaaggaacct tttttcacaa tcagcggttt ttatgttttt cgatcttatt tatgtggatc 2940661 aaaacgtatg tgatatataa actcggcttt gatttgcaaa tcgatactct gttggaggag 2940721 ctaatgctgc tggtcaaccc gctcagcttt attcttcctt tattcgggat cggcctgttt 2940781 ctaaaagaaa acaagcagcg ggcctttttg ctgattgcca atttggttct gactgttatc 2940841 ttgatctcta atacgatttt ttacggcttt tatatcgatt ttattaccat cccggtttta 2940901 tttcaggcca gcaacatgag cgatatgggc agcagtgtaa aagaactgtt ccatcctctg 2940961 tttatcgccc tgtttgtgga tttggttttt ctgctgttgt tcgccagaaa aaccaaacac 2941021 ccacagacaa aagccgctcc ccacacgatc aaacggtact atgcagcttc ctgcggaatg 2941081 cttttatgca cactggcact tgcagaagta cagcagccga agcttttggc acattctttt 2941141 gaccgggaaa tgctagtcaa aagcatcggc ctgtttcagt tccatattta cgatacaatt 2941201 tctcagactg ttaatatcag cgcgaaagct tttgccgatg aagacagtat aactgccatt 2941261 aaaaactaca cagaggctga ttacagcaag cctgatcaaa gcaaattcgg tcttgcaaag 2941321 gggcgcaatg tcatctttgt aacacttgag tcgacccaaa gctttgttct gaatgaaaaa 2941381 gtaaatggaa aagaaattac cccatttatg aatgatctca taaaaaaaag ctattccttt 2941441 gatcatttct atcagcaaac agaacaaggc aaaacatcag attcagaatt tatcgtcgct 2941501 aactcactgt atccctccct tagcggcgcc gtctttttca cgaaaagcga ccatcaattt 2941561 catacgatgt ataaatcgct gaagcagcac gattattatt cagccgtctt tcacgctaac 2941621 cataaaacat tttggaacag agatgtcatg tacgatacat ttggcattga ccgctttttt 2941681 gatgttgatg attttcatgt cactcccggg acatcgacaa gctggggctt aaaagacaaa 2941741 gaatttttag agcagtccgc caaaaagctg aaaagcctac cgcagccgtt ctacagcagt 2941801 tttatcacgt taacgaatca ttttccgttt gagattgatg aaaaggatca gctgatagat 2941861 gaattcgatt caagcagtga tctgttaaac cgctatgtga ccacggttcg ctatgaggat 2941921 gaagcattga agcattttat caaaaaactg aaggacgaag gcttatacga aaattcgatg 2941981 atcgtattta tgggagatca ttacggcatt tctgaagccc ataacgaggc aatggctgag 2942041 tttttaggga aagacgaaat cacaccgtat gacaacgttc agctccagcg ggtgccgttt 2942101 atcatacata tcccgggaat caccgatcaa cagccggaaa ccatccctga tgccggggga 2942161 caggtcgacg tcaggccgac gctgatgcat ttgctcggcg ttgagacaaa aggcgatatc 2942221 caattcggca atgatttgct gtcgggcgac cgcaccccat tcgccgttct gcgaaacggc 2942281 agctttatta cgaacgatta tgtatacaca aagaacacgt gctatagcca aaaaacaggt 2942341 gaagtgctgg aagatcagga tgcgtgcctc ccttacaagg agaaagcaaa cgaagaactg 2942401 tctctctctg ataaaatttt aaatggtgac ctgctcaggt tttccgaatg aaaaaatccc 2942461 tctatcaaga gggatttttt acgtttccaa tatcaccttg ccagtcagct tcgtttcata 2942521 gccgtttaaa tgagacagat tcgccttgta gtcctcagaa ttcaaaatct ccttcacggc 2942581 tttgagcaac tgctcatttt ttttcaaaac aacgatatca tattgttcgt cgatgagcgg 2942641 gataaaatca acactgccca tatgtgccgc gtgctgtgcc ccgattcccg cgtcagcctg 2942701 tccgcttgaa acttgtgaag cggcagcgta atgatcagtc acgatatcgc catatcccac 2942761 tacatcagcc ggattcacac caagcaagcc aagctgttca tcaaggagca cccttgcgcc 2942821 agaacccttt tccctgttga tgatccggat atcggctctt ttcaagtctt tccagccttg 2942881 aatgtttttc ggattccctt tttgcacata cagtcctgct ttgcggagaa cgacattgat 2942941 gagacaaaac ggttcacctg tcaaaatccg ttttacataa ggcgcgttat actggcccgt 2943001 ttctgcatcg tacaaatgga ggctgacaat gtcacacttg ccttgataca tatcaatcag 2943061 gctgtttaag cttcctttgt atttacggag cggcgtctcc tgaatggcat tctccaaatg 2943121 cttgctgagg atatccatcg aaatgtcctg tccgctgatc atgacatttg gtctgccgtc 2943181 cggctcagcc tcctgcacct gtttcggcgc ttcttttgca gcgatgggct gagacattct 2943241 catattcgtt ttatattgct ttaaatcttc ttcatccaca cgcatctgcc ttccgacacg 2943301 gtaagcaggc agcacgcctt ttttaatcaa gtcataaacg gtcagctttg ataccttcag 2943361 cagacctgca acttcttcta tcgtatagga agaggtttca ttcatcatca tcactctcct 2943421 attttattat accttttcgc cgaatgtaaa aaaacccaca taaaccaaac ataatcagtt 2943481 ataattagtt atatctaatg ataaggggtg caatcatgtt taagaagtat tctattttca 2943541 tcgcagcctt aactgctttt ctgcttgtag caggctgttc ttcaaaccag tcttcaacgg 2943601 acagcgagaa aaaagtaacg ttaaccatct cagctgccgc cagcgcgcag gatgcacttg 2943661 aggaaatcca aaaaaattat gaaaaagatc atcaacatat aaccatccaa gataactatg 2943721 gctcatccgg cgccttgcaa aaacagattt ctcaaggagc aggagcagat ctgttcttct 2943781 cagctgctga ggataaattt aaaaagctgg tggatgatgg agatatcgca aaaaaagaca 2943841 gcactgaatt agtcggtaat gaaattgtgc tggtcgtacc gaaaaacgga gattcacctg 2943901 tgacaagctt cagcaatctg gctgaatcag aaaaaatcgc tcttggcact ccggaatccg 2943961 taccggcagg agcttatggg aaagaatcac tgacaaagct gtctttatgg gacaaagtga 2944021 aggataaaat tgtgtatgga aaagacgttc gccaagttct ttcttatgtt gaaaccggca 2944081 atgtagacgc aggtgttgtt tataaaacag atgccctagt ctcgaaaaag gtcaacattg 2944141 ttgacgaggc aaaagcagat acacacagcc caattgtcta tccgttagga atcgtaaaag 2944201 atacaaaaca ccgtaaggaa gcgaaggaat tttacgaata cctgcaatct gatgaagcaa 2944261 tgaaagtatt tgagaaatat ggctttactg ccgagtagca taagcgcttc agaatttttc 2944321 acacccgttg tgctttcctt tcaggtggcg gcagttgccg gaattgttgt cattattctc 2944381 ggaacacttg ctggagcatg gatgtcacgg gcatcatttt tcggaaaaac ggcactcgaa 2944441 acatgtttta tgcttccgct cgttcttccg cctactgttg tcggttttat tctgatcgtc 2944501 attttcggaa agcacagctt catcggacaa gccatcgagt ggattttcca gcagcctgtc 2944561 attttcacct ggtgggccgc tgtgatcgcc tcggctgttg tagcctttcc gcttatgtat 2944621 caatcagcca aaaccggatt tgctgacatt gatcccgata tacaaggtgc ggcaatggta 2944681 gacggcgcta gcagatggaa agtgtttatc catatctccg tcccgcttgc ctatccttcg 2944741 ttactgaccg gaagcatcct tagccttgcg cgggcgctcg gagaatttgg cgcaacactc 2944801 atgtttgcag gaaacatccc cggtgttacg caaacactgc cgacggcgat atatgtcgca 2944861 ttggattccg gcaacaatac ccttgcttgg gcgtgggtcg tctgtattgt tgtcatttcc 2944921 tttttgatgc tgtttttcat tcaacagaaa aaaacgcact aaaaaaactc cccataacgg 2944981 ggagtttttt gattaaaaca gaagctcatc aggatttgga ccgacacgct catctttatt 2945041 taatgcgtca attttgtcca tgtcttcttg agacaattcg aaatcaaaaa tatcagcgtt 2945101 ttcgatgata cggtgttctt taatggattt tggaatggtt acaactccat gctgcagatc 2945161 ccagcgcaaa atcacttgag ccacagattt attgtgtttt tcagcaatct gtgtcagtac 2945221 ttcgttatcc aaaagctgtc cctgcatgag cggagaccac gcttccagct gaatgccttg 2945281 ccctttgcag taatctctta attctttttg cgtcaagcga gggtgaaatt caacttggtt 2945341 caccatcggt ttgatttcag catctttcaa cagctcttct aaatgatgaa cttggaaatt 2945401 gctgacgccg atcgcgcgaa ttttgccgtc tttgtacagc ttttcaagcg cgcgccatgt 2945461 atctttatat ttatctttgc caggccaatg gatcaaatat aaatctaagt aatcaagctg 2945521 cagtctttct aggctttttt caaaggcagc aagcgttgtt tcatagcctt gatcttcatt 2945581 ccacactttt gatgtgatga agagctcttc tcttgccaca ccggattctt taatcccgat 2945641 gccaacgcct tcttcatttt tgtagatcgc tgctgtatca atactgcgat agccattttt 2945701 aattgccgct ttcactgatt cagtcgcttc attaccattt tctactttaa aaacgcccag 2945761 accgaaccaa ggcatttcaa ctccgttatg taactttaca gtatctttta aacttgttgg 2945821 cacttgaacc tccacccttt cactgaaatg taagcgtcta tattatctca cattcctctc 2945881 agccgatacc aataatacgc ttaagaccct ctttttgctt cttttttcac agcacaggca 2945941 aatccaaaca ctattttttt cctattttaa caatattgag attacaaata cattgagcag 2946001 ggtatgcgtg tagtgtaacc aaatgaaaac aaaggaggaa acaacttgaa acgtattcgt 2946061 atcccaatga cacttgctct tggtgccgct ttgacaattg cccctttgtc ctttgcttcc 2946121 gctgaagaaa atcctgctcc gaagatgtcg cagacaacta ctgctggaac aactgccgct 2946181 gatgtaggtt taaacgtcaa cctggatgta cttggaattg ccaaccagat cgctgatgcc 2946241 atcaaatccg cacagaatag ggatggcttt gtgaaaaacc tcatggagtc ttccttctac 2946301 gcgtccggcc aaaaatataa cgtcatggtc tttaatttaa gccaggaata tgaagatcat 2946361 ttgaacggtg tgcaatttta cggctcagcc gtttacgacg gcattacgta tggcatttgg 2946421 gtatttgaag atggaacctt tacaaacaaa ggcgatggcg gctggatcaa ctgggccttc 2946481 agaggctggt tcgaccggga tggcagcact gtcgcatttc atcgccctta atataaaaaa 2946541 agctggcgct ctaacgccag ctttttttct gcatttattc gccgccttca agcatggcgg 2946601 cttcgacatc attaatgtat tggcgaagct catgggagat gtcccgggaa atttccctct 2946661 cttcgaagag cgtttgaatt tcatttctga tcgcctgcac agccttcagc ttcacttcca 2946721 gcttctgatt ttcaaaatgg gcacttgatt ttaactcatg atggctgtgc tccagcctga 2946781 aaattaactg cttatagaat gtaatgacag ataaaaacac ttctttatgc tcatccgtct 2946841 tatgtttttc cagatattct atcgctgctt ttgccgtttt cactcttgtt gcccgtatca 2946901 atcccgcttc atttaaaatc gacatctccg gctttttatg ttcaccgaag aaaatccaat 2946961 acatcagcct cttgagcctt gtttttgata acccgacttt aaacgggttg gcatacaaaa 2947021 tttccaactc gttaaatcgt tcttgcagca catttgctgt ttcttccggg atgtctcccc 2947081 gctccagcat tttcatcagc gcctcttgct cagccttaac cccctgcgca cggacttttc 2947141 gctcgtgctt cttaatgcga ttagatgatg tatactgctg aaaacgaaga tttttcattt 2947201 tctcattgta ttcagctatc accgcaagag aggccgtttt gtttgtctca ttcatgtcct 2947261 ctttaatcgt ttgaagggct gttttgatca acttgcgtct cgccgtcagc agcttcttat 2947321 ttcgttcctc gtcctcttct tctttttcag tcagaattgg cagcacaacg gtggcaatga 2947381 caagcgtgca taaaatgacg ccggctgcta aaaagagaat cagatttctt tccggaaacg 2947441 gcgtaccgtc ctccaggaaa tacggaatgg aaaaagaacc tgcaagcgtt actgctccac 2947501 gcacaccgga aatcgaaatt aacagcgtcg aacgaagacc cggtttatag atgttctgat 2947561 ctttattaaa gaaccatttg ccgttccaga agaacagcac ccacaggaat ctaaggagca 2947621 ttaatgtaaa tgtgatgact aggatatagc cgatcacctt catgttgctg atggcagtgt 2947681 cgttaaagat aacagaaata acatcaggga tttgcgtgcc gagaataacg aagaccaggc 2947741 cgttcaaaat aaataaaata atgttccacg tacttgagga gacgatttgc agcttgatca 2947801 tcgttgattc cagacgatcc tgttcaaccg catgggtaat accgccagct acaacagcta 2947861 aaatgcccga aacgccgatt tcttcagctg ccaaataaat cacaaacggc gtcagaattt 2947921 gaatcagcat atgcatcgtg acatcctgca tgccaaggcg gcgcagaaat aggcgaaaac 2947981 gaataatcaa aaatgaaatg acaaccccgc acagcaagcc tccgagagaa ataaagacaa 2948041 agctgacagc cgcttgtgct aatgaaaatg caccagtcac tgccgctgca atcgcaaact 2948101 taaaggccac cagacctgat gcatcattca tcagcccctc accttccagc aggcgaagaa 2948161 tcccttttgg cattttcact cttcctgata atgcgctgac agcgacgaca tcagtcggtg 2948221 aaagaatggc cgcaagtcca aaggccgctg ccagcggaat agcaggaatc atccagtgaa 2948281 tcgtgtagcc gcctacaatc acagtcgcaa atacaaggcc gagtgcaagc aataaaatcg 2948341 gagcccttaa attccaaagc tctgcccgcg gtgtcctctt tccatcatta aatagcagag 2948401 gcgcgataaa aagaacaaaa aacaattcgg tgtttaattc aaaatgaagt ccctgtggaa 2948461 atgaggcggc aagaatccca agagccactt gaatcagcgg caccggaata aacggaataa 2948521 accggttcac gatattagaa atcgcaataa tcgttaataa tacgagcaca actaaaaata 2948581 tgtccaaatg catgacctcc ttcgtctgtt gtgtgtcggc atgatgagcc aaaaaatctg 2948641 tttgtctaaa agcccttgag ctagggtggc cttgcatccg ctatgtggtt tcgcaggagt 2948701 tctctccaca cttgtcttct tttatagtac cctttttagg gtattttttc tcatgatatg 2948761 ctcacagtga acttttttgc agaagagcaa attatagaaa aaagagacag gaagctactc 2948821 cctgtctctc gtctttcttt ctcaatcatg aaaattcgta ccgtcagttg ttgctttaat 2948881 aatgcccgcg cgaatgacaa agtcaccgaa atgctcgcct tcctcgcgtt ctttcgcata 2948941 gcgggaaaga aggatgcgca gctcgcttaa aatgtctgct tcaccgatgt tttcacggta 2949001 cattttgctt aaacggcttc cgtcaaacgc agcgccaaga tacatattat atttgcccgg 2949061 cgcctttccg ataaatccga tctcaccgag tgcatgacgt gcacagccgt tcgggcatcc 2949121 tgtcatgcga atggtgattt cctgatcacg aaggccgttt tcgtcaataa tctcttcaat 2949181 cttatctaac agggtcggca aataacgttc tgcttcagcc attgccaatc cgcaggtcgg 2949241 aagagcgacg cacgccatcg agctgcggcg aagcgctgaa tagtgcttgc cgtcagttag 2949301 tccgtactgt tcaattaaag cactgatttc ttctttttta tcgcttgaaa cgttcgcaat 2949361 cattaagttc tgattggctg tcagccggaa ctcacctgta tgaactttgg cgatttcccg 2949421 caagccagtc atcagcttat aatcatcgta atccgttata cggccgcctt cgacaaacag 2949481 cgtgaaatgc catttatcct cgatgccttc cacccagcca tagcggtcgc cgttatgatc 2949541 gaaatgatac ggcttcgctt cttccaggct ccagccgaga cggttttcca attcttcttt 2949601 tacgttttct aaaccgaggc ggtcaactgt gtatttgaac cgcgcatttt tacggacaga 2949661 acggttgccg taatcacgct gaatcgtaat cgttttttca gcaacgtcat acatttgctc 2949721 aggccggcag aaaccgatca ccttggctaa ttgcggatat gtcgcagtat cgccatgcgt 2949781 cattcccata ccgccgccga ttgccacgtt aaaaccgatc agcttgccat cctcgacaat 2949841 cgcaatgaat ccgagatctt gtgaaaagac gtcaatatca ttagacggcg gaacggcaat 2949901 accgatttta aacttccgcg gcagatagag cggtccgtac attggctcga cttcttcctc 2949961 cggcgtgccg gcaactcttt cctcatcaag ccaaatttca tgatatgctc tcgtccgcgg 2950021 cagcagatca tcacttaatt ttttagacca ctcgtatacc tctgagtgga tttcagattg 2950081 ataagggttt gatgcacaca tgacgttacg gtttacgtct ccgcaggctg cgatcgtatc 2950141 caaaagtgct gagtggatcg tctgaatggt tttcttcatg ttccatttca gaattccgtg 2950201 catttggaat gtttcacgtg tcgtcaattt taatgtgccg ttcccgtatt tctgggacag 2950261 gtcatccatg acaagccatt gttcaggcgt cgagacgccc cctggcatac gcacgcgcag 2950321 catgaactga tatgcgggct caagcttctg cttttggcgt tcatttcgga ggtcgcggtc 2950381 atcctgcaaa taactgccgt ggtgtttcat caggcggtta tcatcatccg gaattcccgc 2950441 actgattcga tcgagcatca cttctttcag cgtgccgcgc aaataatcac tttctttttt 2950501 aatgcgttca acatcacttg gagagccgtc cggtgctttt agaattttgg tcaccatgtt 2950561 gaaaaactcc tttcaagtca aatcaatata catcacgctg atagcgtttt tgctgctgca 2950621 tatcggcaag ataagcctcc gcctcttcgc ggctcatatt gccttctttt tcgataattt 2950681 caagcaatgt gttatggacg tcatgcgcca tgtgcttttc atctccgcaa atgtaaacag 2950741 ccgctccttc ttgaagccat tcaaacaatt ctgcgctatg ttcaagcatg cggtgctgca 2950801 catatacttt ttcttccgta tcacgtgaga acgccacatc catttttgtc agcacaccgt 2950861 ctttgagcca attctgccac tctgtctggt aaaggaaatc cgtgacaaag tgctgatcgc 2950921 caaagaacat ccatgccttt ccttccgctc ccgtctcctc acgctcctgc ataaacgaac 2950981 ggaaaggtgc gacgcctgtc ccagggccca ccatgataat cggtgtttca gggtctttcg 2951041 gaagcttaaa gttttgattg tgctgtacat aaaccggcag tgtgtctccc ggctgcagtc 2951101 gttccgcgca caaaatcgag cagacgcctt ttcgttcacg gccgtgcgca tcgtagcgga 2951161 ctgcgccgat tgttaagtgc acttcatccg gatttgcgga taaactgctt gcaatcgaat 2951221 aaaggcgggc aggcattttt cgcaaaatcg agacaaactc ctgcgcagat acactaaatg 2951281 ggccatagtc acggacgaga tcaagcaaat cgcgcccttc aatataggct tttacattct 2951341 cctcatttcc cggggctaaa agctctctaa gctcatcgtt ccctgtcagc tgggctgcct 2951401 gttcaagaag cggttttgtg agaacggtaa tctcatagtg agaaatcagc gcttctttca 2951461 gcggtcggac atcaccttgc ttattaagcg tcacaatttc ttccgggtcc caattcattt 2951521 ccttaaggag cagctcgaca agttccggat cgttttccgg atagacgccg aggctgtcac 2951581 caggctcgta agtcaggcca gatccttcaa gagacagctc cacatggcgt gtttctttat 2951641 ttgatcctct gccgtttaaa tttaaatttt ctaacacttc agcccgaaac gggtttgttc 2951701 tggaatacga agactcaccg gtttgtgacg cagccgccgg cgcaggcgcg gcgcttccgc 2951761 ccccagcttc atttaatcct ttcaatacac cctcaagcca ttcggctgcc ggttcatcat 2951821 agtcaagatc gcaatcaacg cgcggagaaa tccgttttcc gccgagttct tctaagcgtt 2951881 gatcaaattc tttccctgtc tggcagaaaa attcgtacga actgtcacca agcgccaaaa 2951941 cggaaaagcg caggtcttca agcttaggcg cccgtcttcc gtgcagaaat tcatgaaacg 2952001 acagcgcgtt atcaggcggc tcgccttctc catgcgtact gacgacgatt aaaagattgg 2952061 ttaccttctt cagctgattc ggcttaaaat cgctcatgga tgagacggtc acttgaaaac 2952121 cgctctgttc aagctgcttg ccggcatttt ctgcaagccc ctgtgcgttt cccgtctgtg 2952181 aaccataaag aacggtcact tcttttgaaa cggccggtgc cggtgcttcc gctgacacag 2952241 ctgccgccgg cgtacccgca gcttcttggg cggaaacaga ttgagcggat aaatatccgc 2952301 tcagccagat tttctgggat tcggtcaagg tcggcagaag gcggttaagg agctctgcct 2952361 gctcctgatt aaacggactg ttcattacct gaagttgcaa cgtatccacc tcacaaagtt 2952421 ataaactgat cgaaaattgc atctaattga actttaccgg aatactaggc ttaagtaaaa 2952481 tatatttaca tgatgataac tattaagaat cctaatgata aaacggctat gcttcatgta 2952541 aatagaaaaa agagaaggac tcccttctct tcattcagca atctgatata agtgaggcgg 2952601 cacagcggtt acaaacggac tggcttcacc tgtataaaat accgccagca tgtgcatcgc 2952661 acgggtgcac gcagtatata aaagcctgcg gtcgtgctct gtatgatagt gttcttcaga 2952721 tgcatcatag acaagcactg cgtcaaattc aattcccttc gctaaataca ccggaatcac 2952781 gcaaacaccc ttttgaaatg gttgattttc tttatgaatc aggcgaacat ctgtatattc 2952841 actcatgtgg gcgtgcgcct gtatgcattg atgcgcagtc ttgcagatga cggctattgt 2952901 ttcgtgccct tttttcttga gccggccaat ttcttgcgcg agcttttggc aaaggctctc 2952961 atgtccttca gttttgacaa cgagcggcat ttccccgctt ctattaaacg gctcaatatc 2953021 cgctccatct tgaagcatcg ctttggtaaa ctcgacaatc tgccttgttg atctgtatgt 2953081 tctctttaaa cgaacatact cagcaggctc atcctcaaag cacgcatcca tacgctgatc 2953141 cccgtttatg gtatgcgcgt agatggactg attgatatca ccgagcactg tcatgctggc 2953201 agccggaaaa atgcttctca tgtaagccat ctgaaacggt gaatagtcct gggcttcgtc 2953261 aataaataga tgtttgattt tcgtattttt ctttctgccc tcaatcagat cctgcatata 2953321 aagaaacggt gccgcgtcct catagagcaa tttattatcc gtaaatgccg aacgggtcag 2953381 ctcacctatc gcatccatct tctcatgttg aaattttcct ccccagccag aaaacaattg 2953441 caaataaagt tgtgtaacat caagaaatgc aaggagcctg actgcctgtt tgagcggttt 2953501 gaaagctttt ttcacaatga tggcggcaag cagctgctgc tctctttgat aatcgttaaa 2953561 cgtactctcg ctgaaccgtt tcctttcctg cagttttttg tacacgtcca agtagtcctc 2953621 tttgtcaagc agctcagctt catgaacaac ccaatccttt cgccgttcct ttttctcaag 2953681 cttgttaagc tcactcagca gccacttcgc ggtttgctcc atccgattcg gaatggagtg 2953741 attttgatcc aatgagtaaa aataggattg aatttgctcc tttgtgatca gcttttgtcc 2953801 gcggaatata atatttttaa aaatcatccc ttcagaggaa agccgtgtga cgtattcatt 2953861 aatgaattgc tgaaaggata aacccgcctt ccatgtgatt cctgcaagcc ttgttggaaa 2953921 atcgcctccc tttgtttcgg tcaggcaata ttcgagctga tcaaaggggc tttcacattt 2953981 gaacttgcgg ccaagacgat gctcgatata ttcctgaaac gtcgcctgct ccatattctc 2954041 ttctcctaac tccggcaaaa cagaggagac atagctgtta aataagaagt tgggtgaaaa 2954101 caaaacgatt tgtccggcat caatgacacc gcggtgcctg tataacaaat aagcgacacg 2954161 ctgaagcgca gccgatgttt tcccgctgcc agccgctccc tgcacgatca ggatcttgct 2954221 tttttcatta cggataatct gattttgttc tttctgaatc gtagacacga tgtttttcat 2954281 ttgggtatca gagtgatggc ttaatacctc ttgcagcatt tcatcgccaa tcgtcatatc 2954341 ggtattaaac atcgccttga gagtgccgtt tttgatcata aactggcgtt tcagcaccat 2954401 ttccccttct atcgtttcac cgggcacctc gtactccgct tttcctgggg aataattgta 2954461 gtacaaactt gatatcggcg ccctccagtc atagatcaga aagtgttcct ccttctcatc 2954521 caaacaggaa gctaaaccga tataaattcg ctctgcctgc tcctcgccgt tttcaataaa 2954581 atcaatccgg ccgaaataag gcgatttttt caattgatga attcgtttga gctgctgatc 2954641 catgcgccga tgattgtgtt cccgatcaga cagcagctct gcctgctgct taatgctagc 2954701 catcgtttca atcgcttcat gggcatcatc aaaattaacc ttaacatcct cccaaaagct 2954761 ttttcttaat ccgatgatat catgcttcaa cccgcccgca gacgtttcca gaaaccgctc 2954821 ttttttttcg agctccttca gcacctcatc tattctcgac tgctcttcct tccattcctt 2954881 atcctgctga ttcatgaacg gcacctccag aaaatagttg acaaacatag atgaaatact 2954941 gtaaaatata attggataca tatattaaat atatgatgca aactggcaaa tacaatttat 2955001 aatagcacat tcacccaata ccaatcaagg tttgggttat ttatattatg cagaaaaaaa 2955061 ccgatttcac ttcgaaatcg gtttttttgc tattaattat ctaagcgaaa agaacggttt 2955121 ggcagcttcc aattaaacat ataggaacaa acccggcaaa caacgagcac gaaaaacaga 2955181 acgtataagc cgaacgagtt ccccagccag cccaagccga cgattaaacc gccgagcgcc 2955241 gcccataccg catagatttc cgctttcagc acaagcggtt tgcgcccggc aagaaggtcg 2955301 cggatgatcc cgcccccgct tcccgtcagc accgcagcca cgatcacggc actaagcgga 2955361 tggcccattt tgacggcata cagtgcgcct tggatagcaa aggcagcgag gccgatcgca 2955421 tctgataaat tgccccactt attccaatgc ttcagcagca gcttcggaaa cagaaacaca 2955481 attgtaatag ataaaagcgc gatttgaaag tacgctccct gctcccatag cgctgacacc 2955541 ggaacaccga tcagcaaatt gcggatcgct cctcctccaa aagctgtgac aatccctaat 2955601 atataaactc ctaaaatatc atattcctct tccatcgcaa caattgcgcc gctgactgca 2955661 aacgcaatga tgccaatcac actaagcagc tcccaagcca ttctgatgac tcccttttat 2955721 gtttgttaaa ttttctgacg acctctagat tttataatcg ctccagcgta aaatcaataa 2955781 cattttcatg agaaaaaaag ataaatttag agggaatacg gctattgctg atggacatga 2955841 gtttgcgaaa ttaaaaaagc gcccggcata cgcgggcgct ttttttgtta ttcagatttt 2955901 tcgcctttca gcaggcacat aaaaatgata atcaggataa aagcaatcag ggccaggaat 2955961 ggaatcgtaa taaaaccaaa ccagttaata tattggcccg agcacggcac gccgctgaca 2956021 catggcttaa tgccgctaaa gccgggcact ttttgctcta agtaatgcat gatcgaaatg 2956081 aatgccccaa taatcgccat cgggagcaca tattttttca ctcgtgtgtc cccttgaaag 2956141 gtggcgatgc ctaaaatcag gacgagcgga tacatgagga tacgctggta ccagcacagt 2956201 tcacatggaa taaactttct gatttcactg aaatacaggc tgcccagcat agcgataaga 2956261 gccacaaccc aggaagcata taaaaatacg attctatttt tcatattgtt acttcccttt 2956321 cagctctttt tctattgtct ctttgatttc atcataatcc gcaaaatttt tgatcacttt 2956381 atcattgacg taaatcgtcg gtgttgcctg tatgttcatt ttttgattaa ggtcagaatc 2956441 cttttccact tgagaagcga atgtttcctt atcaagattt tccttgagcg tctcaggttt 2956501 tatctttgtg gtgctttttg caagatcacc aaggaggcct ggggttaccc attcctgttc 2956561 cgtatccggc tgtttttcga acagcttttc atggaaatcc cagaaagagt cagggtcttc 2956621 cttccatact tcttcagatg caagagccgc taaccttgaa ccttttccat ggaacatgac 2956681 gttcacgaaa gaaaatttca catcgccctt atcaataaag tctttttgta tttttggaaa 2956741 gatgtcactg ttaaacacct tgcaagacgg acatttgtaa tctccgaatt ctactacagt 2956801 taccggtgca tcgtccttgc caagcacagg ctgccctttg atagacggct gtccggacac 2956861 cgcatcattg ccttgttccg ttttgttatt aatgatgaca atggctgcta gcaatacaac 2956921 aaccacaacc gtaaggatga ccgcgaattt cgcagaagac tgctgtttct ttttcactcc 2956981 gacacctcat cgttttaaaa ttaaaaaaga agcggatcgc aattgaccca cttctttatt 2957041 ttaacaagac aagcgctgat aagaaaaccc cgaaaaaatg aattctctcc gacaatttat 2957101 ttgtttttga gacgcatgac gcgcatggcg ttcgccacag caagcagtgt aacgccgaca 2957161 tctgagaaaa ccgcttccca catggtcgca attccaaatg caccaagaat gagaaagatc 2957221 gctttcacac ctaaagcaaa gccgatgttt tgccacacga ttcgccgtgt ccgtttcgca 2957281 atccgaatcg cttctgctat ttttgacggc tgatctgtca tcagcacgat gtctgcggct 2957341 tctaccgcgg cgtctgagcc aaggcctccc atcgcaaccc ctatatctgc gcgtgcaagc 2957401 accggcgtat cattgatgcc gtcaccgaca aaaatgagtt tttcactagg caaaagctta 2957461 gcttctaatg cttcgacctg cgcgacttta tcttgcggca gcagctctgc atatacctca 2957521 ccaatcccaa gctgttttcc gacggcttct cccgtttgtt tcgaatcacc cgtcagcata 2957581 gctgtctgtt tgatcccaag cgacttcaga tcagcaaccg cctgtgctgc gtcttccttt 2957641 atctcatccg ctatgatgat tgctccggca tagcgttgat ctacagcaac gtgtacgatt 2957701 gttccagcat tttcatccgg gacatcctca atttgttctc tttccatgag ctttttattc 2957761 ccagcaagga tctcagttcc atttaccttt gcaaaaatgc cgtgaccgga gatttcttcg 2957821 tatgactcaa tctcatcgga ggaaagcatt ttcccgtaag ctttacgcac agattcagca 2957881 atcggatgct gtgaatgaag ctcagcgtat gccgccgctt caagtaatct atcctttgta 2957941 aaaccttccg cgggtttgat ttctgtcact tcaaagctgc cttttgttag tgttcccgtt 2958001 ttatcaaaca ccgcgtattt gacttgattc aaagcttcta aataattgct tccctttaca 2958061 agcactccgg cctttgaggc cgctccgatt ccaccgaaga aaccgagcgg aatagagaca 2958121 acaagcgcac aaggacaaga aatcactaaa aagataagcg cgcggtacac ccaatcggaa 2958181 agcgcggcgc cagaaagaac aagcggcgga acaaaggcca gcaataccgc aatgatcacc 2958241 acagcaggtg tataatactt ggcaaacttc gtgataaagt tttctgtccg ggctttacgg 2958301 ctgctcgcat tctgaaccaa gtctaatatt tttgatactg ctgattcctg atagcccttt 2958361 gtgacttcaa tatgcagaac gccgttttga ttgataaagc ctgacattac atcttgtcct 2958421 tccgcagctt ttctcggaac ggactcacct gttaaagcag atgtatcaac catcgctgac 2958481 ccttgcacga ccttaccgtc caggggtatg ctttctcccg gattaaccac aatgatgtct 2958541 cctgtctgaa cgtcctccga cgaaacctgt tcgatgccgt tctttgtttt gagattggcg 2958601 taatcaggcc gtatgtccat taacgcacta attgattttc tggaacggct gaccgcggct 2958661 ccttgaaaaa gctcaccgat ttgataaaac agcataacgg cgaccccctc agggtattgc 2958721 tgaatcagaa aagcgccgat tgtggcaaga gccattaaga aatgctcatc aaacacctga 2958781 ccgcggatga tgtttttgac tgcgcggatt ataatgtcac cgccgataat caaataagca 2958841 ccgaggaaaa ggaaaaattc aatggttccc gactgaacca aatatgccgc tgcgccgaga 2958901 atgacagccg ccgccattct gatcagcata ttgaccattc gattacgata gccatcatca 2958961 gctgatttct ttatatgctt ttggcgaacc gttacatgcg gatcaattga tttcactttt 2959021 ttctctactt tattcgtgac ccattgctct tctttcccat cggctgagac agttaaggtg 2959081 cttgccgcaa aatttaccgc gcatccgtta atgcctttta tgcctttgac tccattttcg 2959141 atttttcggg cacaattgct gcaatccaaa ccgtccagaa catattcctg tttcactagt 2959201 ctcaccttac cttccgattt agggttccct cttcaaagcg tatcaatgag tattgtattt 2959261 attttatata tatgagcata tactcatata taagttacac ctattatatg ttgttttcca 2959321 agaaagtgtc aatgaaaaac aaaaaccggc atatagccgg tttttcattt tactttttgc 2959381 agacgaagag cattcagaac aacggaaacg gagctgaatg ccattgctgc tcctgctatc 2959441 cacggtgcta aaaatccaag tgctgcgatt gggatgccga ggctgttata gccaagcgcc 2959501 cagaataagt tttgtttaat gtttttcatt gtcaatctgc tcatgcggat tgcgtcggca 2959561 atgctgttca gatcgccgcg aataagtgta atgtctgctg tttccatggc aatgtccgtg 2959621 ccagttccaa tcgccatgcc gatgtcagct gtggcaagcg ccggcgcatc gttaattccg 2959681 tcgcctacca ttgctgtctg gcggccttct ttttgcaagc gggcgatttc cgccgccttt 2959741 tgttcaggaa gaacttccgc aatgatattc gcaattcccg cttccttcgc gatggcttct 2959801 gcggttctgc gattgtctcc tgtcatcatg atgacatcaa gacccaactc tttcagacgg 2959861 gcaacagcct tccgcgacgt atccttaatc gtatctgcaa ctgctactag ccccgctgct 2959921 tctccatcaa tggatacaag cataactgtt ttcccttcgg cctctagctc ttccatttgg 2959981 gcgagaagag ccccatgctc aacctgttcg ctctccatta attttcttgt gccgacgaga 2960041 atgctttttc ctccggcttc agccaaaatg cctgcgccga cttttgcttc aaagcgggta 2960101 agtttcggta tctcaagccc tttatctttc acgccagcaa taatcgcttc gccaagcgga 2960161 tgctctgatc ccgtttccgc tgccgctgca aattgaagca aatctttttc ttcaaaacgg 2960221 ccgaatggaa tggcatccgt cagacgcggc ttcccgtttg tcacggttcc ggttttatca 2960281 agaacaattg tatcgagacg atgtgttttt tctaaatgct cgccgccttt aaataaaatc 2960341 ccgaattcag cagcgcgtcc agatccagcc attatgctcg tcggagtggc aagaccgagg 2960401 gcgcaaggac aggcaatgac aagaaccgca atgaacttgc tgatcgcttc ggcaaaatcg 2960461 ccaggagccg cccaaagata ccaaatgaga aaagtgagaa ccgcaatccc caatacaatg 2960521 ggtacaaaaa tgcctgaaat ctggtcagcg agacgctgga tcggcgcttt tgacccttgt 2960581 gcttcctcaa caattttgat gatatgagaa agcgcagtat cctttccgac gttgacagct 2960641 ttaattttca gaaagccgtt tgcgttaacg gttgaacctg tcacgctgtc accaggattt 2960701 ttgtcaacag gaagactttc tcctgtaatc atcgattcgt caaccgctga acggccttca 2960761 accacttctc cgtcgacagg aattcgttcg ccaggtttga cgtaaacaat gtcattaaca 2960821 agcacttcgt cgatcgggat gatttgctcc tgtccgtctc ttacaacagt agctgttttc 2960881 gcttgaagct tcatcagctt tttaatcgca tccgaggaac ggccttttgc ttttgtttca 2960941 aacaacttgc ctaataaaat cagcgtcagc aaaatcgcgc ttgtttcata ataaaggccg 2961001 tctgtatgcc cgtgagagcc aatgctttga aaagttagat aaagactata agcgtaagca 2961061 gccgtcgtac cgagggcgac caatacatcc atattggcgc ttttatttct aagcgcctta 2961121 tacgcaccca cataaaacgg ccagccgatc agaaactgga ctggtgtcgc cagcgcaaac 2961181 tgcatccacg gattgagaaa tatatccggt acccaaatga atgatgtaaa tgtaaaatgg 2961241 ctcaccatcg cccaaagcaa tggaaatgac aggacagctg aaaaaatcag tctcgccgtt 2961301 tgcttccgtt cttctttctt tttagcagca gcctcactgt cctgttcacc cttcaacttt 2961361 agcttatatc caagcttatc taccgcttct ttcaaatcgc tgacagacgc ttcttttgga 2961421 ttgtattcga ccgtaactgt ttctaaagcg aagtttactg gtgcatttgc gacgccttct 2961481 attttgttaa gccgtttttc aatccgattg gcgcaagccg cacaggtcat gccctcaata 2961541 tcgaattcag ctttttctgt aacgacgtga tagcccagct tctctatttt ttcctgaatc 2961601 gctgcagtcc ctgtttcagc aggatcgtag attacatttg atgtttccgt tgccagatta 2961661 acatttgcat ccgtgacacc gggcatccgc ttcaggcctt tttcaattct ggcagcacat 2961721 gccgcacagg tcataccaga gacctgcatc gcgatttcct tttgttcact caacatactc 2961781 actcctttat atacacctgg ggggtatata aaaatgaaag aaatatcgcg cctccctaaa 2961841 ggcgcgatac cttgaatcac ttggctacgt catagccctg atcttctatc gcatccgcaa 2961901 tatctttgac tgatactttg tcagcatcaa acgaaacatc gactttaccc gcttccagat 2961961 tgacatgaac ggcactgacg ccgtccagtt ctcctacgct tgtttctact gctttgacgc 2962021 agtgctgaca agacattcct tcaacttgca atgttttttg ttccatatca attcctcctg 2962081 tttattcttt ctattttcat cctaccatac ccccgtaggg tattacaata aaaaacgctt 2962141 tatgattttg tgaacttttt aaatacgtcc aaaagctcag aaatggcctg ttccccgtct 2962201 ccgcttttga tggcatctgc tacacaatga tgggcatgat cctcaagcaa atgaagcgcc 2962261 acatttttca ttgccgcctg aacagctgaa atttgcacaa gaatatctac acaatatctg 2962321 tcgttttcca ccatgttttg aatgcctctg acctggccct caatccgctt aagccggttt 2962381 gtaatctgat ccttttcttt cgagctttta tggtttaatg ttttatgttc gttatgcttt 2962441 tccatgcgta cacctctgtt taatgatatt aattcccatt atactgattg tccaaacggt 2962501 tgtctaagca tgccgacgca aaaaatgaat cagttaggtt ttaccatttg atcaggaggg 2962561 tatatacttc tgttgataac gcttttaaag gggagaagaa aagtggatac gatcaaggtt 2962621 ggaatattag gatacggatt gtccggttct gtttttcacg ggccgctgct ggatgttctg 2962681 gatgaatatc aaatcagcaa aatcatgaca tcacggacag aagaagtgaa acgggatttt 2962741 ccagatgctg aggttgtaca tgagcttgaa gaaatcacaa atgaccctgc cattgagctt 2962801 gtcattgtca ccaccccgag cggccttcat tacgagcata ctatggcatg catacaggcc 2962861 ggaaaacatg ttgtgatgga aaaaccaatg acagcaacgg ccgaagaggg ggaaacatta 2962921 aaaagggctg ccgatgaaaa aggcgtatta ttaagcgtat atcataaccg acgctgggat 2962981 aacgattttt taacgattaa aaagctgatc tctgagggat cccttgaaga tatcaataca 2963041 tatcaagttt cctataaccg ctacagacct gaagttcaag cgcggtggcg ggaaaaagaa 2963101 ggcactgcca ctggtacgct gtatgatctc ggctcccaca tcatagacca aaccctgcat 2963161 ttgtttggga tgcctaaagc cgtgactgca aacgtgatgg cccagcggga aaatgccgaa 2963221 acggttgact attttcattt aaccctggat tatggcaagc ttcaagccat tctatacgga 2963281 ggatcaatcg ttccggcaaa cggacctcgt tatcaaatcc atggaaaaga ttctagcttt 2963341 atcaaatatg gaattgacgg acaggaagac gcactcagag cgggaagaaa accagaggat 2963401 gacagctggg gtgcggatgt tccggagttt tacggaaagc ttacaaccat tcgtggctcc 2963461 gacaaaaaaa cagaaacgat tccatcagta aatggctcct accttactta ttaccgtaaa 2963521 atagcggaaa gcatacgaga aggtgctgcg ctgccagtca ctgctgagga aggtattaat 2963581 gtcatccgca tcattgaagc cgcgatggaa agcagtaaag agaaacgaac cattatgctg 2963641 gagcactaaa acaaaagcct ccccaaataa ggggaggctt tttcattaga atgtttttcc 2963701 tgcttctttc gcacgcgcaa tcgcgtcttc tttgatttgc tgtgctttat caggctccgc 2963761 attatgtccc tctacgaaaa tgccatcgaa tgatggtacg ccgaagaagt tcatcatgat 2963821 gccgatgtag cggtgcccca tttccatctc agccgcaggg ccttctgaat agtagccgcc 2963881 gcgcgcttgg atatgaattg cttttttatc agttaacaag ccgacaggac cttgttctgt 2963941 gtatttgaat gattttcctg caacagcaac agaatcgaga tacgctttca tcactggcgg 2964001 gaatgagaag ttccataaag gagtaacaaa tacgtactta tcagctgatg caaattgatc 2964061 gctaagctct cccaaacggc ctactttcgc tttttcgctt tcagaaagct cttcaaagcc 2964121 tgtacctgac tgaagctttc cccatccgct aaatacatct gcgtcaatgt gcggaatgtt 2964181 ttctttgtac aaatcgatat gtacaacttc atcatttgga ttcgcttctt tgtaagattc 2964241 gataaatgct ttacctgttg ccatactgta cgaagttgct tcgtcatgtg gatgagcagt 2964301 gatatataat acttttgcca tttttaccag ccctttcgtt tttaaaaatc acacatcaat 2964361 tattatcata cagatgcata atgattattc tgtctctctt agactttatt atagagacaa 2964421 agaaatttac tttcaagtaa aacatctcga attaaagatt atttaacttt cccaaacagc 2964481 ttacttttca aaagctgttc tcaagccgga atacagcgcg gacaattctt tactgatccg 2964541 aggataatga gggacatgcg gcacttgaat atccgcaggc atccttttca tgataaagga 2964601 ttgctcagcc tgttcaaaaa acgcccgcag ctggttgatc tcttcatcag aaaacggagc 2964661 agacggacgg cggtgagctt gcgccgagag caaatagtac cctaagtgct gagcaccgga 2964721 aatggcaggc cagagcgcat ccgcattcgc gtgaggaaac tcgccaagcg ccttgtcata 2964781 cgcatcccga agcctgacaa gactcaccct taacttgtgt tcgtcggcaa tttgcccggt 2964841 taacagtttc tccataaact gcccttccag ccggatgaca ttccgcacaa gttctggcag 2964901 ccgcttggtt gaaaaccgcc gccacaaaag cattgttccc aacagcccga tcacgctgcc 2964961 gacagctaca tcagtcagcc tcgctatcat aaaataaccg gcgcccgccc cgccatgcat 2965021 actttctgtg ataacaagcg catttgcggt taaaaaggga acagccagcg cataattgcg 2965081 gacgatcagc atctcaagaa gacattgcag cgctgcaata caaaacgcaa tataaacacc 2965141 gcccggctta aaaaacagga ttgcgcctgc cagtataaca ccgatcaccg ttccggccga 2965201 acgctgaata gccctgtgaa gcgtaaaaac aacagtagtg ccaagcatga ccgctgctgc 2965261 cgaaagcgga atccaatagg agcgtgcaaa gccgaatgcg agggcaaaca tatcggcggc 2965321 aaacagaaca attccgtact ttaacgctct aatcaaaact ggagacttcc agtcaaaggc 2965381 atttctcaaa aagtaaaaag aggatggcag gcggcttggt tccccgtcaa gctgcttatc 2965441 aaaacgtcct gaagcgatat acaaaacctc attgatttct tcaaacagct tccgcctagg 2965501 ctcagattca ttttcattaa tctgaaacgt attgaaaacc cgtgcattcg caagcatatc 2965561 tccggtttgg cgaagtgcct tttcaatctg cgcggtctct ctgtccggcg tttcagctga 2965621 aaaatgaata atggcaataa atatgtcgtc agctttctca aggaggcgaa aaaatcgttc 2965681 atcatgccgc gattttttcc gtctgttccc tttcccaaga accgtttggc gggctgttct 2965741 aagcatgagc accgtctgat gctgtgcgtt atgaaaacct ggcgttccga cggctgaaag 2965801 acatgcagcc agctgatgat atgttttttg cagcaccgct ccctccggtc catgtttgtt 2965861 ccataaccag ccgattaaag cgatacccat ggcgaaaatg ccgccgagaa acgtcagtcc 2965921 cgctctgaac agcgcttgtg aaggatcggc cggcagcccg gaactgacta aaaaggcaag 2965981 gacaaaaaac atcggcgcag ggccttgaat gccgagcgcg ctaaaaataa acatcgccgc 2966041 tgcaccgatc agccccaaaa cagccgccat catccaaagc atcccggaca aaagcgtccc 2966101 taaaccaaat gagagggcga tcccaataga aaccaagagc agcttcaagg cgcgcttttt 2966161 gtacgattca ccgcccgcat ataaataaac aaagcctccg atacttgcaa ttaatccgta 2966221 atccgtgtga cctgccaatg caccgaccag cacaggaaac cctgaagcga aacctgatcc 2966281 gatagccttt ttccaaggaa atggatttgc atgaatgcga aaggcatcct tcacgatagg 2966341 catgattctt tgattgttcg cagcagtttt gttcatttga caaaatcctt ttcaatgaat 2966401 gtgtagaact tttccagttt cttcgcttta gtatgcccaa aaacgcggtt agcttctcaa 2966461 ttggtgcgca cgataaaaaa acagagactt ataccgtctc tgcttcatta catcagttta 2966521 ttataaaagc ggcacctgtc aggactgttt tgtccttctg ccttccttca agagcaggtg 2966581 aataaaaaat aaaggataaa tcaatagata cccattaaac agccaccaca caagatcaaa 2966641 gtcactgctg aatgtccaga atgatagcgc ctgcagacct gaacaacagg tcagcacaag 2966701 agaaatcagc gccatcagct tccagtcagc acgattcacc cgctgtaggt acaagctgta 2966761 caaccctgtg acagaaatca ggatatccag cggaaaaaaa gaccagttcc aagcgatcat 2966821 aaacggatgg tcatgatgtt taaaagccca gctttccggt atgagcgaaa atccggctga 2966881 cagccagtac aagataaaac cgatatcagt cacgagaaaa aacagcttca tatatctcat 2966941 ttgtactgcc cgcttttatg taccggctca gacaccgcaa catgctcgat caggtttaaa 2967001 gacacaacac cggcaataat caatccaatt gaaatgactt tcatgacact cacatgttct 2967061 tgaaaaaaca aaaaaccaac gactgtaatc aagacaattc ccatccctga ccatacagca 2967121 taagcaactg atacatcaat ggatttaagc gtaagcgtca gaaagaaaag actccctcca 2967181 taaaagaaaa tcaacagcaa actgggaata agctttgtaa aaccagacga tagcttcatg 2967241 ctgacagttc ccgcaacctc aaacaaaatc gccaagcata gaaacaccca attcatgtgg 2967301 catcagcctc ctcatcagct gttataccgt taaacaaaac atctacaatt gattcaagta 2967361 cctctcctgt cgtgaactga tgtttcagcg gatattcagg gtcatacact tgattgatgc 2967421 tccctatata catgtgaaca aacaggtccg gattgatgtt tctgattctc ttttgctgtt 2967481 tgcactcatt taataatgct aggacaatcg cccattcttc cttaataaac gcgtctaatg 2967541 taagccacgc atcgtaatgg tatttcttta gttcatttaa taatcccatg ttcagcagtt 2967601 ccatcccctg cggaaggctg atcagcattt gtttcacctt ttcgagcaca tttaaacttt 2967661 cattttcata gatgtctctt tctatttgct tcatttcagc tataaattgt tcgacaaccg 2967721 cctcaacaag ctgatcttta gatgaataat atgcatagag cgtccgcttg ctcgttccca 2967781 gcgctgccgc caaatcattc atcgtaaatg aaaatccttt ctgcttgatc agccggaagg 2967841 tttccgccag aattctttta tccatattaa tcccccgctt tcggtaccaa gaaaactatt 2967901 tcggtaccaa tattatacgg cagaaattta tggaaatcaa caatatataa aaaaacctct 2967961 cctattggga gaggtttaaa agacactgcg gaccaaaccg ccgtccgccc gaagtgccgc 2968021 gccattgatc gcagaggaaa gcggactgct taaaaatgta acgaagtggg cgatttcttc 2968081 cggacggatc agtctttgaa taatagatgt cggccggttt tctttcataa aacgtgcctc 2968141 agcttcttga acagtcaggt tttcaccagg atacagcgag ttcagcatgg tttccacacc 2968201 ctctgttaag gtagagcccg gcatgacggt gttgactgtg acattcgtgc cggttgccag 2968261 ctccgccaaa ctgcgggaaa tggacagctg catcgttttt gtcgcactgt aatgggccat 2968321 ttcctgtgac ggcataatcg ccgcttcact ggcaatgaaa atcacacgcc cttctttttt 2968381 ctctatcatg ttatgcaaat acctgcgtgt cagccttaca ccgctcataa tattcacttc 2968441 aaaaaaacga aaccattcat cgtcgggaat atcaaagtac tccgccggtt caaaaatccc 2968501 taaattgttg accaaaatat caacctctgg atatgcctga aacagctcat tgcagccttc 2968561 ttctgttccc aaatcaaatg cagccggata aagaaccgct tcagcatgtt gtgttttcag 2968621 ttcatctatc gtttgattca ctttctcttc ccggcgtccg ttaatgatca ctgccgcacc 2968681 ttcttcagct aacgaagagg caatagcttt tccgatccct gatgtcgaac cggtcaccag 2968741 tgcggttttt ccttgtaaat tcagcttcat tattcatccc tccgtttttg attcctctta 2968801 tttattgaca gaaatctgat tggtgaaaca tctgctctgc aatcagtatg aaacagctgg 2968861 gattgaaatg gaagtacgca ctttttggtg cctgtggttt ggagaaaaaa taaagcagaa 2968921 cctcttaaga ggttctgctt tattgtcagt atgtatggag acggtgggag tcgaacccac 2968981 gtccagaaac atcgattact taagcgtcta cgagcgtagc ctgcatattt atggtttcac 2969041 tcatcttctt gcctgcgggc gggccttccg agagctagtc tgttcatctc ttcttacgtt 2969101 ctcagacggg aacgcaagcg tagcctactt ggatgtgctc ttcacagaca cataggcaat 2969161 gtcaggaaga gctcgctgcg cttattaggc agctaatgct acgttttggt taaaactgtt 2969221 agttttgcca gttatattta agtgcgtgtt tacgagatcg cctctcggct cgcagctcaa 2969281 gctcgatcca tccctgtcga atccgtaacg tccccttggt ataagggaaa tacgggagaa 2969341 aatatcaagc tctcactcaa actggctata gtcttattat aacatgatca cggctctttt 2969401 caattgtcaa atccttcaaa tgaatggcgt cgtgatctga tcgtgaacac agtatagcac 2969461 aggcctgatt ttcgaatcaa gcactatgcc tttagaagcc tttttgactg tctctgaacg 2969521 ctctttcgat ttcccgcttc gcgtccttgc gcttcagatc ttcccgtttg tcatagttct 2969581 tcttcccttt tccaaggccg agaagcactt tggcaaagcc gttttttaaa tacagcttca 2969641 gcggaacgag agaatagcct ttttcctttg ttaacccgat cagcttatta atctccttgc 2969701 ggtgcattaa cagctttctt gtccggagcg gatcgtggtt atagcggttt ccctgctcat 2969761 atgggctgac gtgcatattg tggagaaaca cttctccccg ttcgattttg gcgaaggaat 2969821 ccttaaggtt tacgcggccg gcgcgaatcg atttgatttc ggttccttgc agaacgatgc 2969881 ctgtttcata ggtttcttct ataaaataat cgtggttggc tttcttattt tgagataata 2969941 cttttcctga cccttttggc atgccagaac ctcctctctc taaggaaaaa ctgtccacct 2970001 tttgcgatac gctctatttt accaaatgtc acgtaccgct acaatgaaaa gctgtttccg 2970061 aaagaaagca aatagagcgc tgcggcccta tttgctggtt gagctgctat ttcttctttt 2970121 tccgtttctg tttcggagca ttctggaagc cgcgtttttt ctttttcttc ttcggcttag 2970181 tgaaccactc ccctttttcc tcagacggag ctggagaaac aggtgtattg gtgctttgaa 2970241 cacgttttct ggcaggcttt ccgcgttttc tgctccggct gctgtccaat tctctcggac 2970301 gccgcggagt gcctttcatg ccgacaattt caaagtcgat attgcgctca tctttattga 2970361 catcgacaac cttgactgtg atttcatccc cgatgcggaa gacgttgcct gtccgctcgc 2970421 caatcattgc gaaatgctgt tcgtcaaagc ggtagtagtc atctgtcata aagctgacat 2970481 ggacgagtcc ttcaattgta ttcggcagct cgacgaacat tccgaagttt gtcacagagc 2970541 tgatcatgcc gtcaaactct tcaccgattt tatcaagcat gtattccgct tttttcagat 2970601 catccgtctc acgctcggcg tcaactgcac ggcgctccat agatgatgta tgttcggcga 2970661 tatccggcag gcgttcagcc cacttttcct gtgtcgcttc atcgaccttg ccgttgatca 2970721 aatacgttcg gatcagacgg tgaacgatta agtccgggta acggcggatc ggtgatgtga 2970781 aatgcgtata gaattccgtt gacagaccga agtgccccaa gctttgcggg tcgtatttcg 2970841 cctgtttcat cgaacggagc ataacagtag atataaccgt ttcctctggt ctgtcacgca 2970901 cagcgtccag aatgctttgc agcgcgcgcg gatgaatatt ccccgccgtt cctttcacca 2970961 catagccaaa tgtcgtcaca aattctaaaa acttttgcag cttttcagca ttcggctctt 2971021 cgtgaatccg gtatataaac gggacattca tccaatggaa atgctccgca actgtttcgt 2971081 ttgctacaag cataaattct tcaatcagct tctcggcgac agagcgttct ctgatcacaa 2971141 cgtctttaac cgctccttcg tcatcaacaa gcacctttgc ttctttgaaa tcaaagtcaa 2971201 cggcgccgcg gtccatccgc ttatcgcgca gaatttgagc cagacgctcc atgtctttga 2971261 acatcggaac aagaggctcg tatttttgtt tcagctcttc atcatcatca acaagaattt 2971321 tattcacatc tgaatatgtc attctttccg ttgttttgat gacactttgg aagatctcgt 2971381 gctctgtcac ctgtccctga ctgttaattg tcatttcaca agaaagcgtc aggcggtcaa 2971441 cctttggatt taaggagcag atgccgtttg acaatctgtg cggaatcatc gggatgacac 2971501 ggtcaaccag atacacactt gtccctcttt caagcgcttc tttgtcaatc ggcgagtttt 2971561 cggttacgta atggctgaca tcagctatgt gaacgccaag cttgtagctt ccatcatcaa 2971621 gcttcgtcac ggtaactgca tcatccaaat ccttcgcatc cgcaccatca atggtgacaa 2971681 tcacctggtc acggagatca cggcggtctt tcagatcttt ttcatcaatc gtgtcaggcg 2971741 tacttgatgc ctgttccatc gcgtcagctg gaaattctcc cggcaggccg tgcttatgaa 2971801 tgaccgataa aatatcaatg cccgggtcgt ttttgtggcc gagaatggtt tcaacctcac 2971861 cctctgcgtt catgcggcct tcaggatagc tcgtcagctt gacaacaacc ttatgccctt 2971921 ccgcagctcc atttttccca tttttcggaa tgaagatgtc actcgtgatt tttttgtcgt 2971981 ccggaatgac aaagccgaag tttctcgttt ctgtatacgt gccgacaacc cgctgaatcg 2972041 ctctttctaa aatccgtatg acggttcctt cctgcctgga gccgcttgat tgtgagttca 2972101 gacgcaccat gacgatatcg ccgttcattg ccgtatttag ctcattaggc ggaataaaca 2972161 catcacttaa cgacgtatcc tcaggcagca aaaaggcgaa tcctttcgca tgggctgaaa 2972221 tctttccttt tattaaattc atcttctccg gaatgccgta gcggtcgctt ctcgtccgta 2972281 cgataagccc tttttcttcc aaggcgacta acgctttgac gagctcttta aactcctcgg 2972341 cttccgtaat atttaacatc tcctcaagtt cctgaacggt cagaggtttg tacgcctctt 2972401 ccttcataaa cgagagaagc ttttccataa atgcttcttt ttccattatc cgacctcctg 2972461 ttgattacca atcgagcttc tctaaaaatt catacacatc ctgatggacg aggtcacgtt 2972521 ctttgtcgag tgtaatgaca tgccctgatt cctcgtacca tttcagctgt ttatcatcag 2972581 tttccacttc gttgtaaata atattggcgc tttcggtatt aatcatgtgg tcatgacggg 2972641 cctgcaccac aaatgtcggt gaataaatca tatcgacatt attccgcaca tcagcaatta 2972701 agtcttgcag cgccttgagg gtattcatcg gcgttttttc gaattctttc atttcctctt 2972761 caatttgctc cgggcttttc ccctcaaact ttttgtaatt gcgagcgtat gaaagaacgc 2972821 cttgatacat gacctcttca ctcttaatat gcatcggtgc gcacattggg acaattccct 2972881 ttatgggtac agtgtaaccc aatttcagcg aaaaaacccc gccaagcgac agtccgcagg 2972941 cagcaatgct ctcataacct tcagatttta aatattcata gccatccatt acgtttttcc 2973001 accagtcttc gggccccgta tgtacaagtt cttcaggcgg gacgccatgt ccttcatatt 2973061 gaggcgcgtg gcacgtatag ccgcgttcat tcaaatatcg tcccagcatc cttacatccg 2973121 ctgtatttcc tgtaaagcca tgcagcaaaa gcaccgcttt gtctccgcct ttaaatgtaa 2973181 atggttttgg tgtcacaact ttcatgctca tgtctccctt tctatctgca cgatcatttt 2973241 agttttccac agtttaatca gaaaaaaacg ttttgaatat catccagaaa cgtgaaaaag 2973301 gcctgacttc acatcagacc ttatacaaac attgccctat aggatataag caagcgcaat 2973361 cgttaacacg aaaaacaaga ctgccagcac taccgtaatg cggtgcaaaa ttaaatcaag 2973421 acctcttgct ttttgtttcc cgaagagctg ctccgctccg cctgaaatcg caccagataa 2973481 tccggcactt ttactggatt gaagcaaaac gacaataata agtgcaatgc tgacgataac 2973541 caataaggta atcaaaactg cgtgcatccc atacacctcc agactcactg gctacattac 2973601 ttctatttta catgaaaagg gttggcatgt cacgctgtat cagacgccaa aaggccggat 2973661 aagacgtttt atcttggtta ccctattcat atgaaaaggt caaaggagaa aagcgatgcc 2973721 gcttatcagc atagacagca ggaaacatct tttttatgaa gaatatggac agggaatccc 2973781 tatcattttt atccacccgc cgggcatggg acgaaaggtt ttttattatc agcgccttct 2973841 atccaagcat ttcagggtga tttttccgga tttaagtggc cacggtgata gtgatcacat 2973901 cgatcagcca gcgtctattt cctattacgc aaacgagatc gcgcaattca tggacgcttt 2973961 gcacattgat aaagctgtgt tattcgggta ttctgccgga ggcttaatcg cgcagcatat 2974021 cggcttcacc cgcccggaca aagtgtcaca ccttattctg tccggcgcct accccgctgt 2974081 tcataacgta atcggccaga agctgcacaa actgggaatg tatctgcttg aaaaaaaccc 2974141 cggtttgctc atgaaaatcc tcgctggcag ccacacaaaa gacagacagc ttcgcagcat 2974201 attaacagac catatgaaaa aagcagacca ggcccattgg catcagtatt atctggattc 2974261 gcttggctac aactgcattg aacagctgcc ccgcctagaa atgccaatgc tgtttatgta 2974321 tggcggcctg cgggactgga cctttacaaa cgcaggctat taccgaagat cgtgcagaca 2974381 tgccgaattt ttcagattgg aatatcaggg acatcaattg ccgacaaaac aatggaaaac 2974441 gtgcaatgag ctggtgacag ggtttgtgct gacacatcat tcataggaat agaaaacgct 2974501 tggcttcctt gcgttttttg ttactttatt gacttttgtc aacgaaatca tagtaaaaaa 2974561 gatcctcaaa tttcaaatta aaatagtgaa gcattttacc aatcacaagc tgccccggcc 2974621 ttctttctcc attcagcacg cggctcagtg tggcgggtga gactccgatt tccagcgcaa 2974681 gctgattaag ggaataatcg ttattaacca tatactgcaa gacataatca cgtctaatct 2974741 gtatcttttc tactggcact ttcctcacct tccattcctg aaaaactttt ttctatactt 2974801 ttacattacg gcttatgtta acttttgtca atacatttcc agtctaccta ttccctttag 2974861 tcaataaaca tactaaaata tgagtaacag tgagggacgg ggtgagatat atggaaagct 2974921 ttggcgaaca attacgggca ttgcgtgaag agagaaagtt aacagtcaac cagctggcga 2974981 cttattcagg cgtaagcgcg gccggcatct ccagaatcga aaacggaaaa cggggcgttc 2975041 ccaaacctgc caccatcaaa aaactggcag aggccttaaa aattccttat gaggggctta 2975101 tgtacaaggc tggttacatc gaagaagtgc atgaagccag ggccccttat gaaacgaagt 2975161 gcaagctgct tgaaaaagcg gaggcctatg acctgaaaaa ccttgcgctt cttgagaacg 2975221 aaaagtggca atatctcaat aaagaagatt tgctcatgct ggatcattat ttttcgttta 2975281 tttcagatga agcgaaaaaa cggtctgctg atgactgact cttgatagaa atgtgaggcg 2975341 atagaccatg tcaccgttcg gacagcaatt acgggagctg cgccgcgccc gcaaactgac 2975401 agtgaatcag cttgcggtgt actcaggcat cagctcggcc accatttcaa aaattgaaaa 2975461 cggcaaacgc gggacgccaa aacccgccac gattaaaaaa ctggcagccg tcctgaaagt 2975521 gccgtacgaa aacctaatgg ccgccgcagg ccatattcag gcctttcctg aagaaatccg 2975581 cgaagcatct gaaggctatc aatccgttta tgaaatttac cagacggctg tcacacgcgg 2975641 agcggagcac ctcccgattt tcaatagtca aaaatgggaa catctctcaa agcaggatat 2975701 tgaaaatctc agcaaatact tcgatttttt gtcttcagaa gcaaaaaaac gcgcctcttc 2975761 ctcataatcc cctgtttctc tttctatatt ttatcaatca cgcttgcatg ccctccctcg 2975821 ttatttgcgt tataatagtg acagacgagg tgaaaagtat gaaccaatca gaaatgtgtc 2975881 ctagatttga aaaagcagtc gacatcttaa gtaaacgctg ggtcgcttta atcgtatttc 2975941 agctcttgaa cgggtcgcag cgatttagcg aaattgaagc agcacttcca aatctaagcg 2976001 gcagagttct gtcagaacgg ctgaaagaac ttgagcttga aggagtagtg aagcgggatg 2976061 tcatccctga aactccggtt cgcatcgaat attcattgac tgataaagga aaggcactag 2976121 cacccatatt aggtgagatt tctaaatggg cgactgaatg gattgaccct tcctttcttg 2976181 actaattgct aaaatggttc tgatctcaaa gacgagaaaa gaaccgtttt ttattttcca 2976241 ggtgaaaaaa agatatctca gccgatatat agtacatcca cacattacgt ttttaaagga 2976301 gaccactata tgcgactgac gatttcccgc aaattcagcc tggtattttt gacactgatc 2976361 ctgatcaatt tacttgtagg cggaataggc gttcttaata tgcagcatat cattcaaaaa 2976421 acagatgaaa tcaacacaaa atggattgac ggcatcaaag gaatcacttc aattaattat 2976481 gtaaccgagc acctgtcttc taaagaaaag gactttctga tttatacaga caaaagtaaa 2976541 atggatacac ttgatcaaga aatgaatcaa atcatggaag acattaacca aaagctcgat 2976601 aactacgaaa aaacgatctc cactgataaa gagcagaaac tgttcgagca gcttcaaact 2976661 aaagtgaata cctatatgga tattcatgcg caaattatcg aaagcggccg cacgaatgac 2976721 atggacaaag caagaggttt attggttcag actgaggcca gctttgagga tatgaaaaaa 2976781 acaatcactc agcttgttga cttaaatcaa gaaggcagca acacagcggt aaaagaaacg 2976841 aaggccgtct atcataaagg gctcatttac actgctttgc ttgtggcagc atcaatcctc 2976901 atcagcattt tcatctggct ttatatcacg cgaaacattg taaagcctat cattcgcatg 2976961 aaggaatctg ccaatcatat tgccgaaggc gatttgtcga acgatatgga ggccctcaac 2977021 tcaaaagacg agctgggtga tctgaatgaa gcgctgcaaa aaatggtagg gaatctgaga 2977081 gatattgtcg gatattctaa agacatatca agccgggttc tttcttcttc acaggtgctt 2977141 gcaaccgcaa cgaatgaaac aagatccggc agcaaacata ttaccgagac gatgaacgaa 2977201 atggctgagg gctctgaaca gcaggcccaa gacgcggtga cgattgccga atcgatgaat 2977261 gagtttaccg aaagcattga taaagcctat aatcacggca tcacaatcag cgatacgtct 2977321 caaaacgttc tcgaactcgc ggtaagcggg aacgaaaata tggctacgtc attacagcaa 2977381 atgaaaacca tccatcatat tgttgaagaa gccgtgcata aagtgagatc actggaacag 2977441 cattctcagg atattaacaa gctcgttcag gtcatcaacg ggattgccga gcagacgaat 2977501 ttgctgtccc ttaacgccgc gattgaagct gcccgcgctg gagaaagcgg caaaggcttc 2977561 gccgttgtgg cagaggaggt cagaaagctg gctgacggcg tttctgattc cgtgcaggac 2977621 attacccgga ttgtaaacgg gacacagcag gagatccaca ctgtcattac gtacttggaa 2977681 agcagcttta cagaagtcga aaaaggaacg gaaaacctga cagacaccgg acaggctatg 2977741 cagcatatca aacaatccgt cacccatgtt gcagacagca ttaaggaagt aacggatggc 2977801 ttgaagcagt taacaaacca atcgattacc atcaatcaat cgattgaaaa tatcgcttct 2977861 gtatccgaag agtctgccgc cggcattgaa gaaacatttt caattaccga gcaatccgcc 2977921 cattcgatgg atcaagtgct tctaaatgct gaagagcttg agcagctggc caatgagctt 2977981 aatgagaaga tgggtcagtt tacgatttaa agagaaaaaa gaggctggac tccagcctct 2978041 ttttctattc tatgcagctg attgaacatg tttcgccccg gttctttttt tcttcaccgg 2978101 acttaatgcc cgctccagcc aagccatgag caaatccgcc cctaccgcca tcaccgcagt 2978161 tggtatcgct ccggctagaa taatcgcagt tccgtttgtt gcgtttgagc cgcgtacgat 2978221 catgtcccca aggcctccgg caccgacaaa tgtgccgatc gctgtaattc cgatggcaat 2978281 gacgagagcc gtgcgaaggc ccgccataat gacagaaagt gcgagcggga gctcaaccat 2978341 tctgagcact tggaatttcg tcatgcccat tgcttttcca gattctaagt aggcatgttc 2978401 aatactgata atgcctgtgt acgtgtttcg aataatcggc agcagggaat acagaaataa 2978461 tgatagaatc acggtatttg cgccgagccc cataacaagc attaagacgg ccagcatagc 2978521 gagcgccggg attgtttgaa taacgtttgt tacggcaaac acccaggctg acaaacggcg 2978581 aaaatgcgcg atgaggattc cggccggaac cccgacgaca gcggcaaata aaacgccgta 2978641 agccgacatg agaaagtggc ggccgaattc atccatgacg taactgccat tctgcgcgta 2978701 atacgtcatt aactgttcaa gcacgttcat tgacctcttc cccctttcac gattcgaaat 2978761 agcgatgttt ttctaaatat tccttggcaa cgacagacgg ttctttgaga ttgccgtcga 2978821 cttcatagtt aagctcctgc atcgtggctg tgtcgatttt tccgagcatt ttcttgatga 2978881 tgccttcaag ttcaggatgt tctttgagca ccttttccgg aacaaccgga gagcagtcgt 2978941 acggcgggaa aaattgttta tcatccttta gcattttgag accataggac ttgattcttc 2979001 catcggttga atacgcaagc acaatgtcca tttttccgct tttcaccgcg tcgtacacaa 2979061 ggccgatctg catcggatac gtgccgccga atgtcatgcc gtaggttttc gtaaaatcct 2979121 gatagccgtt tcctttgagc ttcatccaat agttatcaac gcccagcttt aattgcggcg 2979181 cccatttttt aacgtctgat acggtctcta aatggtattg gtcggccagc tccttgctga 2979241 ctgtaaaggc atatgtatta tcaaacccgt aggagtcata ccactttaaa tcatatcttt 2979301 ttttaaactc ccgctgagta agcgccagcg ctttgtccgg atctttttca ggttccattc 2979361 tcaacgtgcc tgtcagcgcg tctcccgtat atcttgtggc cgcaatgtcg atttccccgt 2979421 tcattaaagc ctgctgctgc accgcgttgg agccaagatt tttaatcgtt gttgttttga 2979481 gatcagtatg gtgttcgatc aactggccaa gcatgctggc gatgatttct gattcgctca 2979541 tgctttgcgc gccgatttta atggtctggt ctgcagcagc gctgagacca ggaagcgaac 2979601 agccgctcag cgtcagcgtt gccgcaagtg ctaaacctat cattaatttg agatattttc 2979661 ttttcatgag ccgcctcctt atgacaattc cttcaatctc tgcatgccgg caggtgtcag 2979721 ttttcgttca gcaactgcca gcacataatc aatcacaatt gccaatatcg tgacaggtac 2979781 cgcgcccccg atgatatatt ccggctgata taaattcagt ccgataaaaa tgtaatcacc 2979841 caatccgccg cctccgataa aggaagcaag cgtggcccag ccgattaagt aaatcgtcga 2979901 tgttctgatt cccgccatga tcactggtgc ggcaagcggc agctccacca agcggacttg 2979961 ttcagccggc gtcattccta ttcctttacc agactcgagc agatttttgt tgacgccgcg 2980021 aatgccggta tacgtgttgc gaagaatcgg caatacggaa tagaaaaaca aagccacaat 2980081 ggccggaacc ttccctacac caaggagcgg gataaaaaaa gcgaggatgg ccagactcgg 2980141 cagcgtctga atgatattga caatgccgat aatggtgccg gctccttttt tcattctggt 2980201 aagcacaacc ccgaggggga cggcaaccag cacacctaag atcacagcaa tgagcgatat 2980261 cgtaatatgc tcgtatgttt tataaagaag ctctccccca ttggtttgca aaaattgaac 2980321 aatatgatgc atgacttatc gcccctccct atgacaatgc tgcgagctgc ttttcttctc 2980381 cccagaggga gtcatacacg atgtcgacca gacttgccct cgtcacaatt ccgatcaggc 2980441 gtcggtcttc atccacaacg ggaacatatt tgacaccccg ttttaaaatt ttgcggaccg 2980501 tgtcgcgcag cagtgtgccg cccagtactg tgtatatatc ttcatgtaaa acttcactga 2980561 cgagattggc ctttttccgg cattgatcaa tgatttcaac atcgacatag ccttgcagaa 2980621 cgcgctcgtc attgacgacc agcaatgaat cgacccgttc ctgcctcatc agctgaatgg 2980681 cctcagaaag cgttttatcc gcggtgatcg ttacaggctg tgtgttcata atctggtcaa 2980741 cccgttcaac atccgggctg gatgactgaa tcagccgctc cttgccgata aattcctcaa 2980801 caaattcgtc tgccggattt cttaaaatgt catcgggcgt tccaacttga acgatttctc 2980861 ccgcttttaa aatcacaatc cggtctgcca gcttaatcgc ttcatccata tcgtgggtaa 2980921 caaatacgat ggttttatgt aaggtttttt gcagtttttt aaattcttcc tggagggaat 2980981 ccctcgtaat cgggtcgagt gccccaaacg gttcatccat taagataagc ggcggctccg 2981041 cggcaagtgc ccgtaataca ccaattcgct gctgctgccc cccgcttaat tcatgagggt 2981101 aacggtctac atattctggc cccatatcga ccaattttaa aagctcacgc gcccgctctt 2981161 tccgctgctg ctccggccat ttcagcagtt ttgggacgag tgagatattc tgctgaatgg 2981221 tcatatgggg aaacaggccg atctgctgaa tcacatagcc aattttgcgc ctgagctcta 2981281 caggatcctg gtccatgatg ttttcgccgt caatgaaaat cttcccggcg gaaggctcaa 2981341 ttaatcggtt aatcattttc attgttgtcg tttttccgca gccgctcggc ccgataaagc 2981401 agataaattc gccttttgca atcttaagat ttacgttgtt cacggctttt ttgccgccct 2981461 tgtatgtttt cgagacattt tctaatgtca gcaaacatcg cacctccaaa attaagttta 2981521 ttcaatttgt tcagtttaaa tttaattttt cagacaattg aatgcttccc attatagaat 2981581 aaagtttata aaataaaaag tttacaattt gttcatatta tttataaagt atgtgtaaac 2981641 gctgatttac ccgcattgac gtgtgttgat ctccttattg ctccaatttc ctgccaaatt 2981701 ctcttttgac agcattttcg ccgtatcaaa aatgtggtat attgacatcg gaattgttag 2981761 ctgaaaggat gaaaccgttg gagaaagatc cgttaacgat cattgaacaa gccgaggacc 2981821 attttataga aagaatcgcg gaaaacatgc atgcatttgg aatgccctct accgtcggac 2981881 gagtgctggg cattatttat atgaatcgaa aaccgatgac gcttacggaa ttatctgagg 2981941 ccaccggcat gagtaaaaca cgtatgagcc aggtagtgcg ggaaatgctt gatgccaaca 2982001 ttgccgagaa ggtattcgaa aaaggcgtgc gaaaagattt atatgaggtt gagcaggact 2982061 actatcaaac atttatcacg ctgttttcag ccacctggag caaagtcgtc agcaaaaaca 2982121 aaatgatgca taaaaaactc aatcgggagc tgcttagcgt gttggatgaa gagcttactc 2982181 ctgaagcgga agaaaaagtg aatgagctgc tgaaggaatt aaaggaatgg ctcgattatt 2982241 ataattggct cagccgtttg attgagtttt ttgagagcga agacattttt aaatatgtgc 2982301 cgaagccgta aaaagttccc aaattcaatt ctgggaactt ttttaagtcc aatccaaatg 2982361 gttgaatatc aaacttcgag ctcccaacgc tggaaaatat gtttaacaga tactaacaca 2982421 tgttgtttat ttaaaaaaac cacctctgtt gtatttaaat agaggtggtt tttctatcag 2982481 ctataataaa atttcctttt ttctttttaa tcgggcttaa tgctcgttca agccagccca 2982541 tgaccaaatc ggcaatcacc gccatcagag ctgtggggat cgctcccgct aatataatcg 2982601 cggttccgtt tgtggcgttt gatcctctga cgatgatgtc cccgagaccg ccagcaccga 2982661 caaatgtccc gatggccgta atgccgatcg caatgacaag cgcggtgcgc aggccggcca 2982721 ttatgacaga aagcgcaagc ggaagctcga ccatccgcag cacttgaaat tttgtcatcc 2982781 ccattgcttt tcccgattca agataggcgt gctcaatact gataatccct gtatacgtat 2982841 ttctgataat cggcagaaga gaatacagaa ataatgacaa tatcaccgta ttagcgccca 2982901 gccccatgac aagcatcagc acggcgagca tggcgagagc cgggatggtc tgaatgacat 2982961 tcgtgaccgc aaaaacccat ccgcttaatc ttctgtatct ggctatcagg atgccgagcg 2983021 gaattccaac aatggcggca aataaaacgc catacaccga catcagaaaa tggcggtaaa 2983081 attcctgcag cacgtaaccg ccgttttgcg aatagtatgt gccaagctgc tgtagtactt 2983141 ccatatgatc cacctctttt cttagtcaaa ataatgatgt ttctctaaaa attcctttgc 2983201 tacgacagac ggctccttca gcttgccatc cacctcataa ttaagttcct gcatcgtttc 2983261 cgtgtcgatt tgcccaatca gcttattgat cacaccttca agttccggat gctccttaag 2983321 caccttttcc ggaatcaccg gtgaacagtc atacggcgga aagaaacgct tatcgtcttt 2983381 taagattttc agatcatatg ctttaatccg tccatccgtt gaataagcca aaaccgcatc 2983441 cattttcccg tttttgactg cgtcatagac tagcccgatc tgcattggat aagttgtgcc 2983501 gaactcaaag ccatatgtgc tgacaaagcc tttatacccg tcgccttttc gtttcagcca 2983561 agcattgtcg acgcctaatt tatattggga agcatttttc ttcaggtcag acacggtgtt 2983621 aatatgctcc ttttccgcaa acttttttgt tacggtgaag gcatatgtgt tatcaaagcc 2983681 gtaggaatca aaccatttat aagaaaagcg cttttgaaac tcgttctgca caatgttcag 2983741 cgcttttttc ggatctttct ccgcttcctt gccgagggtg cttgttaaat ctgttccgga 2983801 atagcgcgtg gctgaaatat caatgtcacc gcccagcatc gcttggtgct gaacatagtt 2983861 tgagccgagg tttttcacta aagcagtatt caaatctgta tcatgttcaa taagctgcgc 2983921 gatcatattc gctacaattt ctgattctgt catgctctgc gccccgattt tgatcgtatc 2983981 gtcagaagcg ccgcctagac ccggcagaga gcagccgcct agcagcatga caaagacgag 2984041 agcaaacgcg ccaagccatt tgatttttgt cattttcaac agtgccaact ccttacgata 2984101 cttccttcat cccttgcaag cctttcggcg tcacctttcg ttctgtcaca gccagaacat 2984161 aatcaataat aattgccaga attgtgacag gcacggcacc gccaatgata tattcaggct 2984221 ggtataggtt cagtccgata aaaatatagt ccccgaggcc gcctcccccg ataaacgacg 2984281 caagtgtcgc ccagccaatt aggtagatcg ttgatgtgcg gatccccgcc atgatgatgg 2984341 gaatcgccag cgggatttca acgagccgaa tctgctccca gccggtcatg ccaattcctt 2984401 tccccgattc caggaggttt ttatttacac ctttaatgcc ggtatacgta ttgcgcagga 2984461 tcggcagtac cgaatagaaa aataaagcga caatcgcagg cacttttcct acgccgagaa 2984521 gcggaataaa aaaggctaaa atcgccagac tcggcagggt ttgcacaatg tttacgaaac 2984581 cgataaccgc acctgcgcct tttttcattc tggtaagagc aacgccgagc ggcactgcaa 2984641 cgataatgcc caatacaacg gctatgagtg aaatatataa atgctctcct gttttataca 2984701 gcagctctcc gccgttcgtt tgcaaaaaag tcatcatttg attcatctta aaagagctcc 2984761 tcccctggtc agatcgtcat gagctggttt tcctcgtcgc cccaaatgga atcgtatacg 2984821 atatcaacga ggctcgctct tgtcacaatc cctgctaaat ggttctgttc atcgaccacc 2984881 ggaacatact tgatcccctg cttcaaaatt tttcggactg tatcgcgaag aagcgcccct 2984941 ttttgaacgg tatatatatc tgaacggtat acatcgccaa cgatgctcgc ttttttgcgg 2985001 ttttgatcaa tcatttccac atcaacatag cccttcagca cgttttgccg gtccacaacg 2985061 agcagcgagt caacacgttt ttctctcatc agctgaatcg cctgagaaag cgttttgtcc 2985121 gcagataccg tcaccggcgt tctgttcatc atttgctcta cccgctcgat atccggtctt 2985181 gactgaatca ggcgctcttt cccgataaat tcttcaacaa actcatttgc cgggtttcga 2985241 agaatctcat caggtgtgcc gacttgaacg atttctcccg cttttaatat cacaatcctg 2985301 tcagcaagct taatcgcttc atccatatcg tgggttacaa acacaatcgt tttgtttaag 2985361 gttctctgca gttttttgaa ttcttcctga agggaatcac gcgtaatcgg atcaagcgct 2985421 ccgaacggtt catccattaa aatgagaggg ggttccgctg ccagggcgcg cagcacgccg 2985481 attctctgct gctgtccgcc gctgagctca tgcggataac ggtctaaata ctctgggccc 2985541 atatccacaa gctttaacag ctcgcgcgcc cgttctttcc gtttttcctc aggccatttc 2985601 agcagctttg gtacgagtga gatgttctgc tggatggtca tatgggggaa caaaccaatc 2985661 tgctgtatca catagccgat ttttctcctc agctcaaccg ggtcctgttc cataatattt 2985721 tctccgtcga taaagatcct tccagacgat ggttctatca gtctgttgat catcttcatc 2985781 gtcgtcgttt ttccgcagcc gctcgggccg ataaaacaga taaattcacc ttttgcaata 2985841 tctaaatcaa tgctgttcac agcttttttg ccgcctttat atacttttga cacttgttcc 2985901 aatttcagca atccgtgcac ctccgcaggt ttcctttaaa ttttctgaaa agtataatcc 2985961 ttattatagt ttgaactttg taaaataaaa agtttacaat gtgttgaaat tatatgttat 2986021 ttatagatta tttattgtta tgaccgagac ggaaagggtg ttcttacaat tactccggat 2986081 acctcccact tcctctgcat tcagctattt tcaacaccag gaagaaatat gatatattga 2986141 caccatcaat tgccatttga agggatgatc agctgtgaaa aaaaccgctc tcgacatcat 2986201 tgaacatgct gaagagcatc tcattgagaa gattgccgaa aatatgcata cgtttggaat 2986261 gccttcaact gtcggacgtg tgctcggaat tatttatatg aatcgaaaac caatgacctt 2986321 aagcgagctc tctgaggcaa cgggcatgag caaaacacgg atgagccagg ttgtccggga 2986381 aatgatcgat gccaatatcg ccgaaaaggt gtttgaaaaa ggcgtacgaa aagaccttta 2986441 tgacgtcgag caggattatt atcaaacctt catttcttta tttgcggcga attggacaaa 2986501 ggtcgtgagc aaaaacaaag tgctgtataa aaaattaaac cgggagctga gtgatctttt 2986561 acaaagggac gggcttaccc cggaagcgga agagaaagtc aatcagctgc tgaatgaatt 2986621 aaaagaatgg cttcattact atgattggct gagcaggttg attgaatttt ttgagagtga 2986681 ggaagtcttt cggtatgtgc cgaaaacaaa agaatgcagc tctctaaaat aagagagctg 2986741 ctttttgcat catgaagtta agaccggaaa catgcctttc agcccggcac caatcatccc 2986801 gaccgcaacc acggctaaga ttaatcccat cagtctggta atcacattca tctcggtttt 2986861 tccgagtttg ctgctgataa aagcagaata gtggaaaaag agaaaggtca gggcaataac 2986921 ggcggctatg ccgatcatga cagccgcata atgaccaatg ccgctatgtc cggcggaaag 2986981 gctcatcact gttgcaatcg ttccgggccc agcaatgatc ggaatggata aaggtgtgac 2987041 tgatatatcc gctttttcct tgctttcctt atgttcatca tggtgaagag attgcacgtg 2987101 cgattctttc gcattcaata gattataggc aatgccgaaa atgaatatgc cgcccgccac 2987161 tcggagcgcg tgaatgttga tatcaaacag tttaaagata agatgaccga aaaccaaaaa 2987221 agctgcgaga ataaaaaagg ataaaatagc tgccttccgg gcaatcgctt ttctttccgc 2987281 tgcagtatag ccttctgtca gcgtcagaaa tatcggtacg tttccgatcg gattcgatac 2987341 tgcgaataaa gaaatgaaga cgtgaacgat aaatgagaac atcatatacc tccttgttga 2987401 tagtctctgc acaggaaata gaatgattct ccaccctttt acccggaggc gatttcccgg 2987461 taaaccttta tagcctgtca gaaacgcgcc atgctacaat gaagtgacaa attgaatagg 2987521 aaggacgtat acagatgttc aaaaaaattg cggcagatgc cttgggctta tctgatatcg 2987581 gaaaaattat cgaacctcag gactatgaca aaacagacgc agatgactat gtcatgcatg 2987641 aagataatga gaaaatttat ttcttgatta aaacaaaagc agacgagtat tgctttacga 2987701 acctggccct gatccatgtg gacggcgaac gcgccacttc ctcaaaacga acgttgaaac 2987761 gctatcctta ttcgcaatat aaaatctctg acgtttttct tgaaactgcc ggaaaagtgg 2987821 atttggatgt tgaaattaag ttcaagctgg gcggtgaaca attcgacatt gatgtccaca 2987881 aagaccagat tgaaaagtta aaagaccttt ataaagcact gcttcgcatc gctgaaacaa 2987941 cctatgaaaa tgacatttta atcaatcaag cggagcaaag cttagataaa gcagtgacga 2988001 ttcttcacca tacccgccct gagcacgtca atattgaaac gcaatacaaa gagctgaccg 2988061 aattcggatt cacttggctg acatccgttc gctcgcagta tcatattaag gattttgggg 2988121 atgtatttga gaaatatatt aataactaga taaaaaaaga cacagctgct atcgtgctcg 2988181 tgtctttttt tgtatgaata ttgattactt tacaactttt ttcttttata ataaaactat 2988241 tagtctattt tccctatatt acagataaag gagttatttt atgtattgtc ctcaatgcgg 2988301 ccatcaaaca gatggcggaa atttttgtga gaaatgcgga tcaccgctcc ccggtcaatc 2988361 aggccaccag catgcagctc aaactggagc cgctgcaaag caagcagcaa aacagttcgg 2988421 ttcatttgtc ttatccgtcc tgaaacgccc ttatcaggaa tgtaaagcaa caggcggaga 2988481 acagctgatc agcgcaatca ttacgatggt tcttttcagt ttgctgaccc ctttgatgtt 2988541 ttatattctt ttttcagacg gtcccggaag cgtaagcttt acagcaatct tcttagagcc 2988601 aaccatttat tttattttat ttctatttgg cctgcatgca tgcatctttt tcgccctgaa 2988661 aatcgcggga aaccaagtgt ctttcaagga ttcattctca agattcggag catttcttat 2988721 tccttttacg gctattttga ttcttgccct tttcttcttt ttattacata cagacatttg 2988781 ctttaccata ttagccgttg gtttaatcgg tgcattcttc gccattcctc ctgcgatgct 2988841 gagcagttac cagcattcat ataaagggaa ggttgatttc atttactcaa cgattgtgat 2988901 ttatctgatc atctgcgtta catttcagct tattatcgaa cactatgtca aagaaatttt 2988961 ccgttatatg ctcttttaaa aacaacccca tcacctgctg gtgatggggt tgttttattg 2989021 aatagacgtt aagtaaattc ttccgttctt cactacgccg gtgtaggtcc agttatatgt 2989081 tctgagcttt ggactgccgc ctgattttgt gatatagaat tcttcatacg tcttaatcgt 2989141 gatagccgac ccattttggc tccagctttt cacttcatag ttattaaagt cttctgttgt 2989201 cccctcttta tttaatttcg acacgagatg ctgctggtcg gaataaaggg aactgccttt 2989261 ttcaaggctg tcttccatca gtgagaaatt attttgattc acggcatctg cctgactttg 2989321 cagataactg cccataaata atgtcacttg ttcatctgta acatcgccgc ttgcagagct 2989381 ttcactgcct ttgtttttcg agccagccca ggcggaagtg tatgtctctg gtttatcatt 2989441 tttgattttc tttatatttg tgcctgcaga ttcgaatgtt gattctgcat cttcgaaaat 2989501 ccactttttc tgttttttat catatgaaag aagatattca taactcggac tgtcgtcagt 2989561 catttcagac tttgtatagt cgttatacga agaagactgg tgaagttctt ttcctgttac 2989621 cgatacctgc cacgttccgt cgtttttctg agagagggca aatgtgtcca ggtcaaaatc 2989681 agtttccaag tatctatctt ttaagtatga atccgcgctt ttcatagaat cgacggtgtc 2989741 cttcgtctcc gccttccaat tggcacttgc ctctgtcatc tgggctgtat tcccatcaga 2989801 tagagctttg gagtattgtt ttgttgtttt gacaattgtg ttcataatct gttcctgtgt 2989861 atcttgatca ggaattaacg ttaactccat ttctttatca tcgatcggaa cgccggcagt 2989921 ttttgttttt ccccacggaa attctgcctc gactgaagct gtcattgatc catctgtcag 2989981 cagcggacca tatgttacgg atttgaacgg atctttatga attgatttac cgttaatcag 2990041 caaatctccc ttcccgctct tgatgtcatt cgctaagctg aatgtcacat cgtctgcttc 2990101 caatgagaga tcaacacgaa agctgctatc gccaatcgcc tgaatgtctt cctttttcac 2990161 aaggtcaacg acatcgtttt tcagtttggc tgagactgta tattcgccgg gaatgtacgg 2990221 accaagggtt tgtgcttgat ctgctttctt tacagatccg gcttcctctt tattgacata 2990281 tagatcggta tttttataat tgctgctcac ttcaaaataa acaggtgcta cctttaagtc 2990341 ataatggtca aataccagca ggcttttccc gtctttttcc gcatatacga tatccttctg 2990401 ggctgtttca tcacgcagcg atgcaaaaag ttcatctttt ttgtctggat gatccttcaa 2990461 atatgtaaga aacggtttta cattattttt agtgagttta agattgtcat ttaccggtgt 2990521 aagcagagtc gcgatttggt cctgatcccc atcatttacg gcctgttcaa acttgtctac 2990581 taacctatcc tttgaagtaa aatacgctcc ggttttatat gcggcgaata atataacgca 2990641 cgccgcggca atgctgctcc ataaaatgat ggttttctta gggatcggtt ttcgcggagc 2990701 ctgcctcgtt tctgcagtgc tagctgtttc ttgatttgcc tgtttgctgc cccctccgat 2990761 cggggtgccg cattgtttac aaaacttggc tccttcatta ttctgggagc cgcaattctt 2990821 acaaaataac atgactttcc tcctattcta ctaatttgat aacatttact gcttttcata 2990881 ttttataata aaacagaatg aaattgggaa cgaatgaaaa aattaaatgt ctatcagact 2990941 aaaaaggtgg aatgaatatg caaaagctca ggattgaatt aggagaagaa acaaatgacg 2991001 aattatatga tctattgctg ctcgccgatc catcgaaaga cattgtagat gaatatcttg 2991061 agaggggaga atgttacaca gcttgggccg gtgatgagct tgcaggggtt tatgtattgc 2991121 taaaaacaag gccgcaaaca gttgaaattg taaatattgc ggtaaaagaa tctcttcaga 2991181 agaaaggctt tggcaaacag cttgtacttg acgccatcga aaaagcgaag aagctggggg 2991241 cggacacgat tgaaatcgga acggggaatt cgagcattca tcagctttcc ctctatcaaa 2991301 aatgcggatt ccgcattcag gcgatcgacc acgatttctt tctcagacat tatgatgagg 2991361 acatttttga aaacgggatt caatgccgcg atatggtaag gctttatttg gatctctgaa 2991421 agcataaaaa agccgccgag agaaaatccc ggcggtcttt ttattacttg tttaagttgt 2991481 agaaagagtt gataccgtgg tattgagcag tttcagccaa ctgatcttcg atgcgaagaa 2991541 gctggttgta tttcgcaaca cggtccgtac gagacggagc acctgttttg atttgtcctg 2991601 cgtttgttgc cacagcgatg tcagcgattg tgctgtcttc agtttcacca gaacggtgag 2991661 agataacagc tgtgtagcct gcgcgtttcg ccatttcgat cgcatcgaat gtttcagtca 2991721 atgtaccgat ttggtttact ttgatcagga tagagttgcc tacgccgttt ttaatacctt 2991781 cagaaagttt tttcgtgttt gtaacgaaga ggtcgtcacc aacaagctga acttttttgc 2991841 caagacgctc agtaagaagc ttgtggcctt cccagtcgtt ttcgtcaagt ccgtcttcga 2991901 tcgagatgat tgggtattta gaaacaagct cttcatacca gtcaaccatt tcagcagatg 2991961 ttttcacaac gccttcgcca gacagatggt atttgccgtc ttctttgttg tagaactcag 2992021 aagatgcagc atccatagca agtttaactt cttcgccagg tttgaagccg gctttttcga 2992081 ttgcttcaac gattgtttga agcgcttctt cgttagaacc aaggtttgga gcgaatccgc 2992141 cttcgtcacc tacagcagtg tttaagcctt ttgcgcttaa tactgatttc aggctgtgga 2992201 agatttgagc gcccatgcga agtgcttcac ggaagttagg agcacctaca ggcatgatca 2992261 tgaattcttg aatatccacg ttgttatcag catgctctcc gccgtttacg atgttcatca 2992321 tcggtacagg aagcgttttt gagttgaatc ctccaaggta ttggtaaaga ggaatctgta 2992381 agaaatcagc agcagcacgc gcacaagcca tagatacgcc aaggattgcg ttcgcaccaa 2992441 gtttgccttt gttttcagta ccgtcaagct cgattaaaag ctgatcgatt gcgttttgtt 2992501 cagttacatc aaagccaaga agctctggag caatgatttc gtttacgttg ttaacagctg 2992561 ttaacacgcc ttttccaagg taacggtctt tgtcgccgtc acgaagctca accgcttcgt 2992621 attcacctgt agaagctccg cttggcacta atgcgcggcc gaaagctcct gtttctgtat 2992681 atacttcaac ttcaactgtt gggttgccgc gggagtctaa tacttcgcgt gcataaacat 2992741 caacaatgta tggcatgagt tttgtctctc cttttgattt tcaaattatt tttgaattaa 2992801 agatgttcct gtcatttctt tcggtttttc aacaccaaga aggtctaata acgttggtgc 2992861 aaggtcgcct aggattccgc cttcacgcag cgtaatgcct tctttcgtta caatcacagg 2992921 gactgggttt gttgtatgcg cagtgtgcgg ttcgcctgat tctgtaatca gaatgtcagc 2992981 attaccgtga tcagcggtaa tgatagcgtg tccgccttta gcaaggatcg cgtcaacgac 2993041 ttcgcccaag cattcgtcca ctgcttcaat tgctttaatt gttggttcaa ccattccgga 2993101 gtggccgacc atatcagggt ttgcgaagtt aagaatgatc gcgtcatgct tgtcagcttc 2993161 aatttctttg acaagcgcgt ctttcacttc atacgcactc atctcaggct tcaagtcata 2993221 cgttgcaact ttaggcgagt tgatgagaat acgctcttca cccgggaatt cagcttcacg 2993281 gccgccgctc ataaagaacg tgacgtgcgg atacttttca gtttctgcaa ttcgaagctg 2993341 ttttaacccg tgctgagata atacttctcc gactgtgtta tcaagattta tcggtttaaa 2993401 cgctacatag ccgtcaactg tttcactgaa gtgagtcagg cagacgaaat acaggttctt 2993461 tggataattc tcgccgcggt cgaagtcacg gaagtctttg tttgtgaacg tgttggaaat 2993521 ctggatggcg cggtccggtc tgaaattata gaaaatcaca gaatcgccgt cttggatttt 2993581 cgcaacaggc tcaccgtttt cttttgtgat gacagatgga atcacgaatt catcgtagat 2993641 accatttgca tatgaatcat caacaacatc cagggcgctg cggtaagatg ggccttcgcc 2993701 gtacgccatt gcgcggtacg ctttttctac acggtcccag cgtttgtcgc ggtccataga 2993761 gtagtaacgt ccggaaatgc tggcgatttc acctacaccg atttccttga tttgatcgtt 2993821 caactggttg atgtacgttt tcgctgtctg cggacctaca tcacggccgt caaggaagcc 2993881 atggatataa acctttgtca gcccttcttt tttcgcaagc tttaacagtg cgaataaatg 2993941 attgatatgg ctgtgcacgc ctccgtcaga taaaagaccg aacaggtgca aggctttgtt 2994001 gttttctttc gcgttgctga tcgcgtcaag gaatgtttga ttgcgttcga actctccttc 2994061 acgaatggca acatttacgc gtgttaagct ttggtacaca atacgtcccg caccgatatt 2994121 taagtgacct acttcggagt tccccatttg cccttcagga agacctacag cctcgcctga 2994181 agcagtcaaa gtttgatgag gatactggtt ccaatagcgg tcaaaattcg gttttttcgc 2994241 taaagcgact gcgttcccta ctgtttcgtt acgtaatccg aacccatcaa gaatgatgag 2994301 tgcagctggt tttttactca tattgacctt cctccaataa ttgaacgaat gactgtggct 2994361 caaggctcgc gccgccgacc aaagcaccgt caatatcgga ctctgccata tattctttaa 2994421 tgtttgcagg ctttacgctt ccgccatatt ggatgcgaag cttgtctgca gcttcttggc 2994481 tgaagctttc agcgacggtt ttacggatat gcgcacacac gtcattcgca tctttcgctg 2994541 tagaagattt gcctgttccg attgcccaga ttggctcata cgcaataaca gaagcagcaa 2994601 cttgttcttc agaaagacca gcaaggcctt ttttcacttg gtcagcaaca agatcatttg 2994661 ttttgccggc ttcacgctct tcaagcgttt cacctacaca gatgatcggc acaatgccgt 2994721 gtttgaaagc tgcgtgtgct tttttgttaa ctgtttcatc agtttcagcg aacatttcac 2994781 ggcgctcaga gtggccgatg acgcagtagt caacgccaag gtctttcaga gcaaccgggc 2994841 tgatttcgcc tgtgaacgcg ccgctttctt cgaagtgcat gttttgagcg ccgactttta 2994901 ggtcagtgcc tttcacagca gaagcaagct tttctaagaa aagcgctggc gcgcaaacaa 2994961 cagcttcagc tttgtctgct gctggaatgg aagatttcac ttcttcaacg aagctgacag 2995021 cttcgccgag tgttttgttc attttccagt taccggcgat aattggtttt ctcatctgtt 2995081 ccacttcctt atagcagttt tgagattatt tatcgttcag tgcagctacc cctggaagct 2995141 ctttgccttc cataaactca agggatgcgc cgccgcctgt tgagatgtgg ctcattttgt 2995201 cagcaaggcc gaatttttca accgctgccg cagagtctcc tccgccgatg acagagtatg 2995261 tatctttcgc ctctgccaat gcttccgcaa ccgcttttgt tccttgagcg aacaagtcga 2995321 tttcgaatac gcccattggt ccgttccaca cgacaagttt gctgtttttg atgacgtcag 2995381 catacgtttc gcgtgttttc gtaccaatgt cgattgcttc taaatcacta gggatttcag 2995441 agatcggcac aattttcacg tttgcatcgt tagagaaatc atctgcaacg agtacatctt 2995501 caggcatgta gaagttaacg cctttttctt tagcgcggtc cataaatgat ttcgcaagct 2995561 cgattttatc ctcttcaaga agagatttcc cgacttcata gccaagcgct tttacgaaag 2995621 tataagcaag acctccgccg atgatcaggt tgtctacttt atcaagaaga ctttcgatta 2995681 caccgatttt gtcttttact ttcgctccgc cgatgatcgc tgtgaacggg cggtcaggat 2995741 tggaaaccgc ttttccaagt acatcaagct ctttttccat taagaaacct gcaactgctg 2995801 gcagatgctc ggcaattcca gctgtagatg cgtgagcacg gtgggcagca ccgaatgcgt 2995861 catttacata tacatctgca agctcagcaa atgcttttgc aagctcagga tcatttttct 2995921 cttcaccagg atagaaacgt acgttttcca atacaagaac gtctccgtcc ttcatctcag 2995981 aaatttgtgc ttttacagca tcgccgtatg cttcatccgc ttttttcact tctttgccaa 2996041 gcagttcgcc gagacgtgca gcgacaggag ttaaacgaag ctcctcaacc acttcgcctt 2996101 tcgggcggcc taagtggctc gcaagaagga cttttgcgcc ttggtctgca aggtgtttga 2996161 ttgttggaag cgcagcacgg atacgtgtat cgtctgttac ttccccgtct ttcattggaa 2996221 cgttaaagtc aacgcggcag aatacaactt tgccttttac gtcgatgtct ttgagagttt 2996281 ttttattcat gcctaggaga tcctccttca aaatggtttg catacagcac gaaaaacgtg 2996341 aaaccgtctg ttcaagcgat aactccgcta gggcagatcg cagtcttttt cggcacaggg 2996401 cagttcgtct aaaagccagg gcagcggcct taggcgaaag cgccggcaaa gctgcttaaa 2996461 acgcggtcgt ttctctatca cagagcgttt tctgaaagcc ggtcttcatg gaaaaaggga 2996521 aagggagtcc gtccccttcc cttgtccgct ttcattatag cgcttctatt cgaaagaacc 2996581 aagtcaggtc ctttttcagc tataaattaa agaccttttt ttgcgatgta agctgcaagg 2996641 tcaacaacgc ggttagagta gccgctttcg ttatcgtacc aagagattac ttttaccatg 2996701 ctgccttcca taaccattgt agaaagagca tcgattgtag aagagttttt gtttccgttg 2996761 tagtcgccag aaactaatgg ctcttcgctg tagccaagga ttcctttaag gtcgccttca 2996821 gccgcttctt taagagctgc gtttacttct tcagctgtta cttcttggtt cagttcagca 2996881 accaagtcaa ctagagaaac gtttggagtt ggaacacgca ttgctccacc gttcagtttg 2996941 ccttttagtt caggaagaac tagagaaact gctttagcag caccagttga tgttgggatg 2997001 atgttttcag ctgctgcacg cgcacgacgg tagtctttgt gcggaagatc aaggatttgc 2997061 tgatcgtttg tgtaagagtg aacagttgtc atcataccgc gtttgatgcc gaatttatcg 2997121 ttaagtactt ttgcaaacgg cgcaaggcag tttgttgtgc aagatgcgtt agagataaca 2997181 tcgtggttag ccgcatcgta tttatcttcg ttaacaccca taacgattgt gatatcttct 2997241 tcgttagcag gagcagagat gattactttt ttcgcgccag cttctaagtg tttcgcagcg 2997301 tctgcgcgtt ttgtgaagaa accagtagat tcaactacga tttcaacgcc ttgtttgccc 2997361 cagctaagtt tagcaggatc gcgttctgca gaaacttcaa ttgttttgcc gttaacaaca 2997421 aggttgttac cgtcaactga aacttcagcg tctaattttc cgtgtacaga atcatattgt 2997481 aaaaggtgag ccagcatgtt agcatctgtt aaatcgttaa ccgctactac ctcaacttca 2997541 ggattgttta atgctgcgcg gaatacgtta cgtccaatac gaccaaaacc gttaataccg 2997601 acttttactg ccatgattgt ttcctccttt aaataagtga gagatattta tattgaggga 2997661 ttattcatcc cttaataact tctttgcggc tccttcgtct gtgacgagaa ccgtgttgcg 2997721 tggcttttta aagtaagcct cgatcgcttc ggcttttgat gatccgcccg ctaccgcaat 2997781 aatatcgggg atggcgtcta tgtcatccag ctgcattccg acagaatgca ctttgtgaac 2997841 cacttcgccg tccgcgttaa aatagtagcc gaacgcttcc gtcaccgcgt cgttatcatc 2997901 tattttcttt aaatcttcta aaggcgtgtt tctgcgctga gccatagttt tagcttcgcc 2997961 gattccgtga accagcatac tcgctgattt aatggtgttc agcacctctt tgacagaagg 2998021 ctcttcaata atagatgaat aggcgccttg tgacagctgt cccggaacaa acaaaagccg 2998081 gtaagtgcct gaagccttct ccgccatatg cgcgcatatg gtgttcgcct ggtttttcac 2998141 gtcttcgcct aaaccgcctc ttgcaggcac aaacaaaagc tcgcggtttt tagaatccgg 2998201 cgtcatcatt tcggcgacag cttcaattgt cgtaccgcca gttacagcga cgatattttt 2998261 gcctgaaaat ctttttttca tacatgcgac agccgctctt cccatttctt ttttgaccca 2998321 tggggattga tcgctgtctc cggatacgat aatggcatcc tttagattta aacgttcttt 2998381 taatgtcttt tccaaaagag tcaaacctaa aacatctttc atcgtatctt ccaaaacaga 2998441 aagcagttca tagccctctt ctgtcaatgt catgccgttt gtcttaatat cgaccaggtt 2998501 ctgttccttt aaaaactgaa cctcgcccct cagcacacgc tcgctgattc cgagactggc 2998561 agacaggctt cttcgcccga tgggttctgt cagcctgata tactgcaaga tttcaaacct 2998621 cttttgcata acgagcagaa gatcaggcaa taattttttt tgagcttgta ttaactggtt 2998681 catgactcaa acgttccttc cttttttgct ggacattata tgtcccgcta tgacaaaaaa 2998741 cgtcccgtca tagccaaaaa aaatcatttc tgctttcttt aattatttta acagggtgga 2998801 attgtttatt caactgttaa gagccaattc atcgacaata ttcgcagagt tttcatgccg 2998861 cgtcgtttta tccagcaata ttttatccta tatatcttta tcttatacag aaagcgccaa 2998921 atggtgcatc ccaatataaa cagcccttcc cgtagaaagg gctgtttcat taaagcgttt 2998981 tcattttatc caaagctttt caatttcctc gagcgatttg ttcttcgttt ctggacagat 2999041 cgtaacgaca aacaggaaac aaaggatgtt aatcaccgca aagatccaaa atgtataggc 2999101 gagcccgaaa gaatcgatca tcattggcac aaactgtccg atcgcccagt ttgctcccca 2999161 taaaaagatg gtcgcaatgc ccgcggcccg cgcacgcaga tggttcggga agatttcaga 2999221 aatcataatc catgtgatcg gtccgaccga gacacagaaa gcagcgacaa aacctaatat 2999281 aaggacgatc atcatgatcc cgcttgttaa ctcaaaataa aacgacgtcc cgattaaaat 2999341 cataaaaata gccataaaag cagaaccgat ggacatcagt ttttttcgtc cgactttatc 2999401 aatcagcaac accgcaataa cggtaaaaat aacttctaca accccgacga tacaagtcgt 2999461 cacaaatccg gcgttttgcc cgaatcccat cattttaaag atttccggcc cgtagtaagt 2999521 aatcgcgttc atgccgatga cttggttaaa cagcgccagc aggattccaa tgacaagcgc 2999581 ctttctgaga cccggcttaa acagctggga gagcgacccc atttgttcta tttttaaaga 2999641 gttctcaatg ttctttaatt cttcttttgc aacagtttct ccattaatac gtgtcaggat 2999701 ctttaaagct tcatttgttt tgcccgcttt cgccagccat ctcggacttt ccgggacgac 2999761 gagcaggaca aggaaaaaaa tgacggatgg caccattcca taagcaagca tccatctcca 2999821 gccggtgtgc acgccccatt cgtatgttcc ggaccgctgc acagctagat taataaagta 2999881 tgttgcggaa atacccagta tcgtaaagag ctgatataac gaagataaac ttccgcgtat 2999941 agcgggcggt gccgcttctg taatatacgt aacagagagc gatgagccca tcccgattcc 3000001 cagccccccg ataatccttg caatgattaa ggtggacacg tcttgagaaa gcgctgaaac 3000061 gattgctgat atcgcaaata acaaagcggc tgtcattaaa atttttctcc ggccgaatct 3000121 gtcacttaaa aatccggata tcccgacgcc cacaactcct ccaatcataa tgcttgaaat 3000181 gacaagtccc tccataaacg gactcaggct gtataaatct ttcagaaaac cgatggcgcc 3000241 agaaatcact gccgtgtcat agccatacaa taagccgcca agccccgccg cacatgagat 3000301 caaaatgaca aatcccattg aatggcttct tgttacagga acatttggtt ctaattgagt 3000361 tggagtattc ttcatttccc tgccctcccg aatgttgagt aaagcgtttt catttaaacc 3000421 ttcaattgta cgtacttata ttaaaattta acgaaaatta catttaatta gtacgtacaa 3000481 atatagaata atcttgtttg cattttctgt caatgttttc ttacaaagaa cgctgtgata 3000541 tactgaaatt tgtccgtata cattttggag gaatggatat gttaccaaaa tacgcgcaag 3000601 taaaagaaga aatcagttct tggattaatc aaggcaaaat actgcccgat caaaaaatcc 3000661 ctaccgaaaa cgaattaatg cagcaattcg gcgtcagccg gcataccatc cgcaaagcga 3000721 tcggagacct cgtatcacaa ggtctgctgt acagcgtgca aggcggaggc acctttgtcg 3000781 cttcacgctc tgctaagtca gcgctgcatt ccaataaaac gatcggtgtt ttgacaactt 3000841 acatatcaga ctatattttc ccgagcatca tcagaggaat cgagtcctat ttaagcgagc 3000901 aggggtattc tatgcttttg acaagcacaa acaacaaccc ggacaatgaa agaagaggct 3000961 tagaaaacct gctgtcccag catattgacg gactcatcgt agaaccgaca aaaagcgccc 3001021 ttcaaacccc aaacatcggc tattatctga acttggagaa aaacggcatt ccttttgcga 3001081 tgattaacgc gtcatatgcc gagcttgccg cgccaagttt taccttggat gatgtgaaag 3001141 gcgggatgat ggcggcggag catttgcttt ctctcggcca cacgcatatg atgggtattt 3001201 ttaaagctga tgacacacaa ggcgtgaaac ggatgaacgg atttatacag gcgcaccggg 3001261 agcgtgagtt gtttccttct ccggatatga tcgtgacatt tacaacggaa gaaaaagaat 3001321 caaaacttct ggagaaagta aaagccacac tggagaaaaa cagcaagcac atgccgacag 3001381 ccattctttg ttataacgat gaaattgcgc tgaaggtgat tgatatgctg agggagatgg 3001441 atcttaaagt gccggaggat atgtctattg tcgggtacga tgattcacat ttcgcccaaa 3001501 tctcagaagt gaaactaacc tctgtcaaac atccgaaatc agtgcttgga aaagcagccg 3001561 ccaaatatgt cattgactgc ttagagcata aaaagccgaa gcaagaggat gtcatatttg 3001621 agcctgagtt gatcattcgc cagtccgcac gaaaactgaa tgaataaaaa aagcaatgta 3001681 tgggtctccc cgctacattg ctttttttat agctgttatc tgtttttcca aacgtcagcg 3001741 atgatttcaa acgaacgcat tctgtctgcg tgttcaaagg tttctgagtt aaccataatt 3001801 tcgtcagcct gtgtcgtttt gacgaaatct tcaagcttcg ccttcacttc ttccggacct 3001861 ccgacaatcg tggagctcag ctgctcattg accatcgctt tttcatacgg gctccagatt 3001921 tggtccatat cctcaacagg cggtttaagc tggttaggcg taccgcggac aagatcaaga 3001981 aacctttgat aatgggaagt cgcaaggtgc tgcgctttct cgtttgtatc tgccgcgata 3002041 atggtgacac cgaccatcgc atacggttcg tcgagcacgt ctgacggcgt gaaggaattg 3002101 cggtacagct ccaaagcggg aaccgtattc gccggtgaga aatgggccgc gaacgcaaac 3002161 ggaagaccaa gttcgccagc cagacgggcg ctgaagccgc ttgagcccag cagccaaatc 3002221 ggcacatcta tgccctctcc gggaatggcg cgaacttgat tgcgcacatt tcctgacggt 3002281 ttaaaataat tgcgcagttc ctctaattgt tctggaaaat cctccccgct gttgatgttt 3002341 ctgcggagcg ctctggctgt caattggtct gttcccggcg cacgtccaag ccccagatca 3002401 atccgcccgg gatacagtgt ttccagtgtg ccgaattgtt cagcaatgac taatgaagag 3002461 tggttgggga gcataatgcc gccggaaccg acgcggattt tcttcgtgcc tccggcaata 3002521 tggccaatca aaactgcggt ggcagagctt gcaacacctt ctatattatg atgttcagca 3002581 agccagtaac ggtgatagcc ccattcctct gcccggcgcg ccaagtccat gctgtttcgg 3002641 aatgattctg caatcgttcc tccctgaaca accggagata aattcaagac agaaagcaag 3002701 gtatctttgc gttggttgtt agacatattg ttctcctttg caaatgtgtt atcagtaaac 3002761 agcccaaagc tgtcaggtca tgattgaaag aacttctatc acaccataac acaactgcat 3002821 tcaggaataa aagaatttga ttcgatgaaa ttcgaacaat ataaaacgaa cggtttggaa 3002881 cattattctg ctccaaacaa ctccttagcc atctcaataa agagcttagc cgccagagaa 3002941 gcctccttta gcgacggaac agcaagctgc acatcacggt atacctgcgg gtccaattcc 3003001 ctggtcacca catgctctgg cagcggcatc cccgacatgg acatttctga taaaatggcc 3003061 aggcccaggc cttctctgat catactgatc gaggtgttga tgttatagac cgtgaaagct 3003121 gggtgcagcg tagcacccgc ctgcctgaac atatcgataa atggtgattc atagccgccg 3003181 tcacagacga tcatcggttc atggtcaaga tctttcagcg taatggctga atgactggca 3003241 agcgggtgat cgtccctgag cacgacagcc attttgtctt ttttcaaatg aatgtactcc 3003301 atctcctctg ttggatacag aagaatccca acatctatca tccgcgtatg aagccactcc 3003361 ttgacttcat ttacagttcc ctcgtgcagc acgagctcaa gtttcggata tttttgttta 3003421 aattcactga tcagcttcgg cataaaataa gccgaggcag ttgagaatgt gccgatatgg 3003481 atcgttccca gttcaagccc tttttccgct gctgctacct gctcaacttt ttcaatgcct 3003541 tttaagactt ctctgatgtg tactaagatc tgttttcccg tatccgtcag catcaggcca 3003601 ttgcggcggt cacgaatgat cagctttaca tcaagctcag cttcgatcgc agaaatcgca 3003661 tggctgacag ccggctgtgt catgttcagc gcctgacccg cttttgtaaa gcttcccgtt 3003721 tcagctattt tcacaaaaac ctttaattga gtaatggtca taacaattta cttatgctcc 3003781 ttataaaaaa gattcatttt atttatctta tgttctaccg tatcatatga tggaaaagtt 3003841 ctacaaggag tgaatgaaca atgaagcagc tcccaaaaac gcggacagct ctcctgctcg 3003901 catttctcgt catcatgtgg ggcgtcaatt ggccgctgtc caaagccgcg ctcgcctatt 3003961 ctccgccatt attgttcgcg ggcatccgaa cgctgatcgg cgggctttta ttagtcatag 3004021 tcgcactgcc gcgtattcat aaattacgct taaaagaaac gtggccgatt tatcttgttt 3004081 ctgctctttt aaatattaca ttattctacg gcctgcaaac gatcgggctg aattatcttc 3004141 cggccggcct gttttctgca atcgtcttct tccagcctgt tctgatgggt gtattttctt 3004201 ggctgtggct cggcgaatcc atgtttgtaa tgaaagtgat tggcctcatc ctcggttttg 3004261 cgggagtagc cgtcattagt gctgcgggct ttggcgggca tatttctgtc attggggttc 3004321 tgctggctct cggctccgca gtcagctggg cgctcgggac agtatatatg aaaaaaacag 3004381 gcagccgcgt cgattccatc tggatggtcg ctctgcagct gacgatcgga agcgtgtttc 3004441 tgcttatctc cggcttttgg acagaaagct tttcggcgat ccaatggaca gctccgttta 3004501 ttacgagcct gctgttcatc tccgtattcg ttatcgcact cggctggctt gtctttttta 3004561 cgcttgtcgg ttcaggagaa gcaagcaagg tcgcatctta tacttttttg attccgctca 3004621 tatcaatcgt ggccagctcc attttcctgc atgaaccgct cacccttagc ctcttggcag 3004681 ggctgctgct gattgtcacg agcatctgtc tcgtgaatac aaaatcaaaa gcgcagaaag 3004741 ctgcggcgat tggtataaac gagaaagctg cacaataata aaaaccctct tgccggatgc 3004801 ggcaagaggg tttcttattt actgatgctt gcgtcctttg accaaatatg caactgtaat 3004861 caaaaggtag atcgccgcag taatgccggt aatgacaatt gatgttgtca tgatgacccc 3004921 gatcagaatg gcgagtaatg ccacaatcgc aaaccatgtc gtgtacggga accattttac 3004981 ataataggcc ggtgtttccg tttgctgttt tctcgatttt aaatgagcga atccgatgat 3005041 cagccaaatg aataaaacgg tatatcccaa tgatcccatt aaataattaa atgtttggct 3005101 tcctgcgaac agagaaatca atacgccaat atagagagaa gaagtgcaca tcagaatcgc 3005161 aaacatcggt acgtttttcg atgaaagctt cgagaagacc tttggaagcc ttccgtcact 3005221 tgcctgtgta tacaaaatgc gtgatgatcc gtataaacct gaattcatag aagaaatgat 3005281 cgccagcagg atgactgcat tcatgatatg atccgcgccc ggaatgccta ccattttaaa 3005341 gaccatcacg aaaggacttt ccggaacgga attgacttgg ttccatggaa tcaggctgac 3005401 gatgatgaaa aacggcagca ggtaaaacgc gacaatccgt gtcagtgtgc tgcggacagc 3005461 tttcgggaca accttttccg gattttttgt ctctgcaagc gttacaccga taatttctgt 3005521 accgccgtaa gagtagatga cgacaagcat cgccgtgatc agccctgtgc cgccgtgcgg 3005581 gaaaaatccg ccgtggtctg tcaggttgga aaatccggat gctgtatgat caccgaatga 3005641 tacaaataag agcagcaatc ccagaataat aaagataata ataacggtaa tcttgatcat 3005701 tgccagccaa tattcagttt cggcgaagat tttaacagaa agcaagttta caatcgtgac 3005761 gataagagaa attcctaatg ccaacaccca gatcgggcag cccggcagcc aatattgaat 3005821 gaaaatcgca gctacaacag cttcagccgc aatgttaagc acccacattt tccagtagat 3005881 ccagtccaaa aagtaagcag cgtaatttcc caatacctgc tggacaagat cacggaaggt 3005941 tctggcgtta cggtttcgaa cagccatttc cgccagcccc tgcataataa acagcaaaat 3006001 aatcccgccg agcaggtatg cgataatgac agatggccct gccacatcga tcgctgagct 3006061 gctcccctta aataaacctg cgccgattgc tccgcccagc gccatcatca taatatggcg 3006121 ggacgtcatc gtgcgtttta acgtttgatt gtcgtttttc atcctcttct acctctcctt 3006181 ctcgttttca aaaacaaaaa agcccgccgt ctcctaccta atctaataga taaagagacg 3006241 acgagccttc ggctgaccgc ggtaccactc ttgttgattc ttcatgaaga atcctgcttt 3006301 tgacctgtaa cgaaggttag ccgttaaaac atagggaata ttcaatctat tccgttccgt 3006361 cttaccactc ccgggcgagt tcaaagaaga atcaggctgc gtcgcaccac cccgcagctc 3006421 tctgttctga tcactttctt ttactgctcc caatctatgt gttttagttt tctgaaaaac 3006481 tcaaatttta tgatctgaat atattaacat aatatacgtg cttctctttt aactgtcaat 3006541 aacttcagag aaaaaagaaa ctgttatttt gtcccttttc gaatggcttt ccaaaaggat 3006601 tctgactcgt ttcctaatgc gtaaactgaa acacctgcta ttttatattg ctttgccaga 3006661 tggcttttcg tttgaacggt tttttcgttt tcataccaca cgacatgttt atgcttcttt 3006721 ttgtcaacat aagaaaacgt catcgagcct gattttttgt tgaatgccgg ctttgctttt 3006781 tgttttttga tgagggattt gagctcattc cattccctta ttgtgctggt acttccgtct 3006841 tttacatccc agtcatagcc gtacgcaggg attcccatga tgactttatt ggctttgatc 3006901 tttttgactg aaaactgcag agagcttttg atccagtttg tgcttgccac tgaccccggc 3006961 tcaccccaaa tgccgtgttc atcgtaggtc atgacttgta cgaagtcggc atatttgccg 3007021 attttcgcat aatcatacgg ccagctccag tcatcatttt tatcatcggc gcttttggcc 3007081 ggaacggata ccattgtttt aatatgtttc ttattcaaag cctgtgagac atattgaatg 3007141 aagttcgagt atgcagcgcg gtcttctgga tttactgctt caaaatcgat attgattccg 3007201 taatatgagt gctttttggc cagtgtaatt aactgatctg tgaatcgttt tttcgctgtt 3007261 ttattgctca tgacccgact cgctaaatct ccgtcaaaat cataaatggc atcattatag 3007321 tttgaaatga cagcccatgt cttgattttt ttctttttcg catatgtcag ctgcttagtt 3007381 ggggcatcgc caatgatttg tccgtttttt tcaaacgcaa atgtatcggt tgcgatggca 3007441 ttcatgtatg tatgatattt cgtaagagaa ttgtatgaag ccgtatcccc agtcgtgtag 3007501 cctactgtca taccggctgc cttcgcttct ccttttgtat acataaacag aacaatcgca 3007561 atcgccagtg aaaccgctat gatcagccat tttttcatcg catttcctcc tgtatcaagt 3007621 catactcttc tcatcggcca aaaaattgga agttgaagtt ttttcaagca aaaagcccgg 3007681 catatgcctg ccgggcttcc tgagttcagc ggtcagagac gagaatatat gctgccttta 3007741 ctggtccatg cacccccaca actaaatcca tttcaatgtc ggctgagtta ctcggtccgg 3007801 taatgtagtt gatacatgaa ggaacagtga caccgttcgc aatgttttgg cggatgatat 3007861 cactggcttg tgtcattctc ggtacaatgc ttgatttcgg cacgatcgca atataagtcg 3007921 ttggcaaaag gctgacagag cggccgatgt cttttgagga gaagaggaca accgtccccg 3007981 actcagccaa tgtaatttcg ctgaatgtaa tccctacatt ggcttgctcc gcttttttaa 3008041 tattttcctc gcctttgtca gcatcccact cccagaccgg cgttccttca ctcggccagt 3008101 ccttggtgag caggcttttc agtccgtatt cttcaaagcg ggggtccttc ggaatgatga 3008161 cagggcctcc agaaaagcgg ctgacttgct cgcgcagggc atcgtaaagg ccggttgaat 3008221 ccgtttcaat cagctctgta tggattttga cacaatggtt tttgagcact gtgactaagt 3008281 catccgctga ataaccttca agtgttttat attgcggctg atgcgcccat tcagggactg 3008341 ccacgcctcc tgttcttcgt tcacggccca ggctggatgc gattcggttt aaaaagctct 3008401 cttgattctg aatggttccc ttcgtcatca ctgctcctcc ttcgtgcgtt cacttgtttc 3008461 tctgtccgca aaccagtctc tgaatctcga tttatgcggt gccgggaagt cgcgaatctg 3008521 ggtccaattt ttaagcgggc cgggcccttt cgaaattttt tcgtcctctg taaaaggcgt 3008581 catggcggcc ggcgcccatt ttgagcccat tttgtaaagc gataaggagg atgcgccaag 3008641 tccgaatgct ttcattgcaa gcttttcact gatcggcgcc ctgccttctt tttcgacgat 3008701 attctgacga tgcttgagta gcagctcatg aagcgggatt ttgaccgggc aggcttctga 3008761 acaagcagcg cacagtgaag atgcgtacgg cagctcctta taatcgtcat aaccgccgag 3008821 caacggtgat aaaacagctc cgatcggccc cgagtagatt gagccgtatg aatgtccgcc 3008881 gacatggcgg tacacaggac agacattgat acaggcggca cagcggatac attgcagcac 3008941 agactggaat tccgttccaa ggatattgga tcgtccatta tcaacgatga caagatggaa 3009001 ttcttccgga ccgtccactt caccttccag cttcggaccc gtcaaagctg taatatagct 3009061 tgtcagccgc tgtccgacag cacttctagt cagcatgctg actagcactt caaattcaga 3009121 aaatgacggg acaatccgct ccattcccat gacggtaatt tgtgttttcg gcaaggtgct 3009181 cacaagccgt ccatttcctt cattggtcac aaggctgacg gaacccgtgt cagcgatggc 3009241 gaagttacag ccggtaatgc cgatatccgc ttccagaaac tttttccgga gaatggcgcg 3009301 cgcatgcatc accagctctt ccggtttttc tgtatgttga tagtccagtc tttctttaaa 3009361 cacatcgcgt atctgctctt tatttttatg aagagcgggc gctacgatat gtgacggcgg 3009421 atcgtgatca tcaatctgca aaatatactc gccgagatcg gtttctacga cttcacagcc 3009481 ttccttctcc agcacctcat tcagattgat ttcctctgtg accattgatt tagatttcac 3009541 aattttcttc ccgttcttct tttgaatgac atcccgaata taggaagacg cctcttccgc 3009601 tgttttcgcg aaatagacat gtccgcctct tttcgccaca ttttcggcaa gctgtccgag 3009661 atagaaatca aggttttcaa ggacatgctg cctgatttcc tctgataatg agcgccactc 3009721 ctcccagttt cccagttctt ctgctgcctc taggcgccgc gtccgcagac gctcctgtgc 3009781 acctgaaaca gcgcctctca taaattcatt atcaatcccc tgtgataccc gctctttaaa 3009841 agcgtcagta ccgattttca tcgccatgat cctttccccc tctgaatcca gttttatctg 3009901 ctgttgagca cttcggcgat gtgcatcact ttgacattct tatcttttcg gccaagccgt 3009961 cccccgatat tcatcaaaca gccgcagtca gcaccgatca gcacctctgc tcccgtttcc 3010021 tccacacatt cgactttttc atcgaccatc tgctcagaaa tctgcgccat cttgactgag 3010081 aacgttcctc cgaatccgca gcagttatgt ttgcccggaa gctctgtaaa ctgcaggccc 3010141 ttcacatggc tcaacagctt catcggctcc ttccgaacac ccagcagcct agtcatatgg 3010201 cacgacgtat gtaaggtcgc ttttgtatga agggtcgcgc cgacatcctc taccccaagg 3010261 acgttcacaa taaaatctgt cagttcatac gttttatccg ccagcttttt cgctttatcg 3010321 gcccatttcg gatcatcctg aaacaggtgc ggatactccc ggaacatcgt tgtgcaggaa 3010381 cccgaaggac tgacaacata ttcggaatcc tgaaacgttt cgatcatccg tttcattgct 3010441 tttttggcgt catgtacata gccgctgttg taagccggct gtccgcagca aatctgccct 3010501 tctggaaaat caacctcgca cccaagccgc tccagcagct caaccgttgc ttttccgaca 3010561 tttgtttgaa acatatcaac aagacaagtg acaaaaagtg agactttcat gatgaacccc 3010621 tctctcatcc ccaatatatg atcaggtcat ctgatgacct gagttaaaat aactatatga 3010681 atatcgtaca ctattctgac aatggaagga aagagttttc tagggatatt ttcatttgtg 3010741 gcatatcaaa aacactcccg atctcccagg agtgcagtat atggttagat ccagcccttt 3010801 tcctcagcga tgctggcggc ttctgtccga tttttcgcat taagcttttg gatgatttct 3010861 gagatatagt ttcgaactgt gccttgagat aaatagagct ccagcgtaat gtcttttgtt 3010921 gtcttgccta aagccgcaag cctcagaatt tcttgctctc taacggttag cggattttcg 3010981 tctcgcatca tattaaacgt cagctcaggg ctgaagacac gttttccctt tacacatttt 3011041 cgaatggcat cggccagatc gtcaatttca ccgtctttca gcagatagcc atgtgcaccg 3011101 gcctttacgg cgcgttcaaa atatccgggg cgggcaaagg tggttaaaat aatgaccttg 3011161 ctgacgcagc cttttttcat taattcctct gccacattca gcccgcttcg aaccggcatt 3011221 tcaatgtcca taatgcatac atccggctcc agcttcaaaa tagcatgtag cgcctcttcc 3011281 ccgtttaatg cttgtccgat gactgtcata tcctcttcta aatcaagcaa agatcccaaa 3011341 gcgcctaaaa gcattcgctg gtcctcagca ataaacagac gaatcattct tttcgtcctc 3011401 caatcattct gcttttttaa taagcggaat cgtcagtgcc acaaccgttc cgttatggtc 3011461 tgaaaccgtt aatccccctt caatgagcat gagccgttct tccattcccc acaggccatt 3011521 cccaaacatt ttctccttcg gcgctccctt tccgtcatcc cgtattacga tcctcatttt 3011581 gtcagcaaat tgagaaatgg tgatggcaca gtgggttgct ttgctgtgct tgataatgtt 3011641 agtcacggct tcccgcatac acatactgat aatattttga gtgacgggag atatcactga 3011701 aaagtcgtcg gctccttcgt attgaaaggt aatgttcccc gctcttaata tgtgctgaat 3011761 gtttacgagc tcctctgtta tcgtgaccgt tctcatatca gaaaccagct ctcgaacttg 3011821 cttgagtgcg gagcgtgaac tggtttccat ttcttttgcc tcaagcttgg tccgttctgg 3011881 atcagatgca gccagccgct gaatgagctg gctttttaat gtaagcagcg acagggtgtg 3011941 gccaagagta tcgtgaagat cacgggcgat tcgaacacgt tcctcccttt tagagagttc 3012001 ttttatctgt tcgttggctt gtgcaagctt agcttcaagc tcaatcctcc gaaacataga 3012061 acgaattccg aatggagaaa tgagcataat gacgagaaac gggagaacag aaaaaagctc 3012121 ccgaagcgag accgaattcg cgataaattg gtataggcat ggaaaaagca gtataaagat 3012181 taaagcgcag aacgcacggt taaaattcgt tttctctttg taataaccaa caaagtttgc 3012241 cggaaaaaaa cctaagtata tataggtgat attgtaaaac acactataca tcaaaataac 3012301 cgccatttgc acgataagcc aatatgtaaa cgaagctttg cccacgctgc agaataactg 3012361 gcgatatgcc gctacaaaaa ggagcagcat accatatccg atcccctgtt tgacccctga 3012421 ttcttttaat aaagagagga acggcataat cgtatacacc agaaagatat aagggaaaaa 3012481 cccgaattcc ttcgggaaaa tagatattgc ctttttcatg tattacaccg cttcttgttt 3012541 tcttcttata tatttagata gtagcatgaa gagcatcata taagcgatta atatcagaat 3012601 atttttccaa gtcggactcc caccccggac aagttcccac gctccgctcc cgaaatgata 3012661 agacggaagc cactggccaa tgctctgcat catgtcaggc atgacctcaa acggcatcca 3012721 catccctccg cctaaagcca gcagcatata aagcacatta ctgattccgg ccgctgtttc 3012781 tacttttctc atgaggccga ttagtgtgcc taatgctaaa aaaggcaatg cgccaaacaa 3012841 aatccacagt ccgctcatca tccattcaaa cggtgacaag gcaatatcat tgatgattgc 3012901 gccgaacaga aatatgacgg taattgataa aacgtgaatg acactttggc cgatcatctg 3012961 agctgataaa tagatatgat ccggaagagg cgtaaggcgg ataaaggcgg cccagccttg 3013021 tgaccgttct tgtaccattc ggatgccaag cgtcatgata gaggaaccca tcacgctgaa 3013081 gactgtcatc gacatcaggt aatgggcttc ccatgcacgt tgatcaggga cgttggtatt 3013141 cactacattt gtaaagaaat aataaaaggc aatcggcatg atcagagacc aaagcacaaa 3013201 gtacttgttc ctaagcaccc ttttcatttc agcgatgctt tgcttttgca gcacgttcac 3013261 tcacatcgcc tccctgttgc cgtcagccag ctggcgaaat gcctcatcga gcgttgcttg 3013321 ctcaattcga atatcccgtg catgtatgtt ttcttgaaag atcagcgcca acactttgtc 3013381 tgtatttgat gtctggatga tggttctctc atgctcgtgg atcactctct cgacttccgg 3013441 gtgacaagac agcctttcca atgattcact tgaatgaagc gtaaaggaaa cagactgttt 3013501 ttgaattctt gagcggattt gcattggtga gccgtctgca acaagctgtc cttcagtaaa 3013561 aaataggatt cgctgtgcgg catcatctgc ttcctgtaaa taatgagttg aaaaaataat 3013621 cgtttttcct tggtccgaca gtccgtgaat ggtctgccag aatcggtgtc ttgatgaagt 3013681 gtccatgccg actgtcggtt catcaagtat aagcagctcc gggttcccgg caagagccaa 3013741 agcaaagctc aaacggcgtt tttgtccgcc ggataatttt tctgctcttg ttttcaaatc 3013801 ttctttggtg agtgctgtta acgaaacgag ttctttcatg gacaatggat tcggataata 3013861 gctccggaag agttcaagga tttcatccac cttaaggccc ggcatgacac ttacttcctg 3013921 aagcattaca cctatttttt cacgaacctg ttgatcatcg ggaacccggt taaatagttt 3013981 gatttctccc tcactcggtt tcagcaatcc taatatcatc gagacgacgg tcgtcttccc 3014041 tgccccattt ggcccgagaa tggctgcaat ttctcctttt tcaatactga agctgatgtt 3014101 gtttacagcg gtttttcgct ggaaatgttt tgtcacgttg cttactgtta ctgcttcttt 3014161 catcacatga gcacctcctg atcgtttaca ttgattgtaa aatgacggag aagacgatgt 3014221 tagtatgggg tgtcatgatg atggagtgac aaatgtcatt tttttctcac cccggtgtct 3014281 aggcaatcct cctcctgcat cttccaattc atccatcttt tctatctccc atgtcctctt 3014341 tcttttaaac tgctgtgaca ttcatagaaa gatacactct tcaaaccatc cgagtgttat 3014401 gatagaaata ttgaacttta tattactttc cggctgaaag gagccaatca tgaacgaagc 3014461 gattttgtct agaaatcatg tgaaggtgaa aggcagcggc aaagcatcta tcatgttcgc 3014521 acctggtttt ggatgcgatc aaagcgtgtg gaatgccgtg gcacctgcct ttgaagaaga 3014581 tcatcgggtg attttatttg attacgtcgg ttcgggacat tcagatttgc gcgcatatga 3014641 cctgaatcgt taccagacac ttgacggcta tgcccaggat gttcttgatg tttgtgaagc 3014701 tttagatctg aaggaaaccg tgtttgtggg tcactccgtc ggggccttga ttgggatgct 3014761 tgcatccatc cgccgcccgg agcttttttc ccatctggtg atggtggggc cttctccttg 3014821 ctatttgaat gatccgcctg agtattacgg aggatttgaa gaggagcagc tccttggctt 3014881 gctggagatg atggagaaaa attatatcgg ctgggcgact gtatttgcgg caaccgttct 3014941 gaatcagcca gatcggcctg aaattaagga agagcttgaa agccgttttt gttctactga 3015001 tcctgtcatt gcccgccaat tcgcgaaagc ggcgtttttt tctgatcacc gagaggatct 3015061 ttcgaaggta acggttccct ctcttattct ccaatgtgca gatgatatca tcgcacctgc 3015121 aacagtaggt aagtatatgc atcagcatct gccttatagc agtctgaaac aaatggaggc 3015181 tcgcggacat tgccctcata tgagccatcc agatgagacg atacagctga tcggcgatta 3015241 tttaaaagca cacgtgtgat ataggaacga aagggataga ggtgaccctc ttagatggac 3015301 aaacaattga atgatgcacc atgcggtttc ctcgctttgt cagaagaggg gtcgatcata 3015361 gctgccaacc gcacccttat caagattctg gattatgaac cggagcaggt tatcggccag 3015421 cacatgaata tgatgttgac cattcccgcg cagcttttct gccagcttta tttttttccg 3015481 cttttgaaat tggagcatca catcgaagaa atatacattt ccctgaaagc aagagatgga 3015541 gaagaaattc ccgtccttat caatgctatt gcgagacacg atagcggggc ttctgtcttt 3015601 gattgtgttc tgattccaat gcgaaagcga aatgaatatg aaaatgagct gctgatagcc 3015661 agaaatgagg ctcaggaagc tttgcttgcc aaacagaaag ccaatgcgga gttagaaatt 3015721 gccttggaaa cgctgaaagc aaaacaagaa gaacttcttg agatcaataa acaaaatcaa 3015781 caatttaaat taaacaccaa aagagagctt gaactcgcca gaaagatcca gaaaaactcg 3015841 ttgactgaac cgattgtaaa cgatcaggtt cagattgact cttattacaa cgcatcgagt 3015901 gaattgtcag gtgatcttta cggatattat caaatcgatg aacaccgtta cggcattatt 3015961 atccttgatg tgatggggca cggaatttca tctgcattga ttacgatgtc tcttcatcct 3016021 ttgttccagc gccagatcac gcaaggtctc agccccgtta aagttatgaa ggaattggac 3016081 cggcaccttc acagcttgtt tcaaaatgat gaggaagcaa gacattattg cactgctatt 3016141 tatctcgaga ttgatatagc acggcaaaga attgattatg tcaacgcagg gcatccgccg 3016201 gcactttggc aggacgatag cggaactcaa catctgcttc acgcgacctc gcctccgatc 3016261 gggatgtttg aagacttaga gtttcagtca agcagccttt catacacgga ggacggaaga 3016321 ttgcttctgt atacggatgg cgtgatggat cctacggctt catgttattt atttgattta 3016381 ctaaaggatc atcctgattc gccaatcgct gacctgaagg agaaaatcct tacatcactg 3016441 cagcatcaaa aggaagctca tcataagagt gatgacgaat gttttatatt agttgatgta 3016501 aaataaaatg atccatgaga cataacaatg atttgttaca tctcatggat ttttttgttt 3016561 cagcgtttct ttggaatatg tcctgactcc gcatattgaa acacctgcaa ggaaggcagc 3016621 gggtgtccat taaaatcaaa taaagcttga ttatctacag cacttccccc ataccacttc 3016681 ccggcgtctt cagggtcgta ttcagcagca tagctggacg cccaccctga cccgtatgtt 3016741 tcccataaca ctttgttttt ctctatctgt gtcttcggcc cgactggaat ccacgccggc 3016801 tcccagtaga aaacaccaag tcctgctttg cccgtattcg ccactgcctc cattacatct 3016861 cttactgcag ttgcctggcc ttgaacagaa attggatatg gcaacgtctg cccgcttttt 3016921 ggtgctgtat ttccatgccc atcgccatcc tcagcggtat aggtgtacga tgtctccgcc 3016981 accatgactt ttttgccgta cgtattggca acagccttca gcacggaggt caaattttgt 3017041 aatgtgccat gccagaaagg ataataggag ctagcaaaca catcataatc cactttgttt 3017101 ttgctgagtg tttctgcaat aaatgaatac cttccagccg tttcaggatt ggtaaaatgc 3017161 agggcgacca aaatatttga atttgtctcc ctgaccgctc ggcttccttc attaaataat 3017221 tggcacatct tcgtccaatc agtctcaccg gcaaatcctc ctgttgtttc atttccgacc 3017281 tgaaccatgc cgatgtcaac gccttccttg atcatctttt gcaggctttg tttcgtatac 3017341 tcatagagct ttgctttttt tgcttcaaag ctgagattcg cccaggcttt gggcaccttt 3017401 tgtttcgctg gatcggccca gaaatcagag tagtgaaagt cggccagcac cttcattccg 3017461 ttcgctgtcg ctctttttcc gatttcgatg gctttttgaa catcattgtt tcccccgcca 3017521 tacccgttgc catttgaatc atacgggtga ttccagatgc ggacgcgaac atagttgacc 3017581 ccagcctgtt ttaaagttgt aaagatatcc tggcgttttc cgtttgtatt gtaaaaggtg 3017641 acaccgctgt tttccaaagc aataacgctg gatacatctg cccctttgat aaaatccttg 3017701 ttcatcccct ctactttttt aacaaaaaga tcctctgccc gaagctctga cacgtgcttc 3017761 tccttctcaa tggcagcggc atatcctgtt gaactacatg cactccacac gatggcagcc 3017821 gcaaagaaca ttttcacttt gcttttcatg atttcatccc cccaagactt agcaagcgtt 3017881 ttcattctat agaaaaaaga atccgcccat atcgagcgga gcatcagcct aatgtgtgtt 3017941 tacgacaatt ctcacttcat acttttccat cgtcaggtcg cctgacaata tgtctcctgt 3018001 cattatgtcc ttcacactct gatcaaacgt gaccagctgt ttttcttccg tgaaattcat 3018061 gacaaaaata taatcattgt cctgatcctg cctcgcttgt acggagacgc cttttccgtg 3018121 ccgaaccgga aaaactggag agagagacag gtctgtgatc agaccctcat agaaatcacg 3018181 ctgaaattga tcctccaaac gcgcgccgat aaaatacgcc ttgccctgct gatactcatg 3018241 gcttgtgacc gctggcgtgc gcgcataaaa atcttcttga tacaccgctt ccactgaagc 3018301 tgtctttaca tcaatcacgg ttgcataatc cttcatttca tatatttggc tgcggtagct 3018361 gacagcgttt cgatccttcg gatacagggt gtccgtttca agaggctcaa ctccaaatat 3018421 agcttgaaga tccggatgcc atccgcctgt gtatgttaag tcatgctcat tcacaacccc 3018481 gctgatatac gtcatgacta aggtgccgcc gtcagccgta aacgctttta aacgggaaac 3018541 ggtgtcctcg ctgattaaat acagcatcgg gacgatcagc agtttatatg gtgaaaagtc 3018601 ttgttctttc gtgatgacgt cgacagggat atcgtgttcc cagaatgtgc ggtaatgctg 3018661 ctgaagcgtt tgcggataac gttttgtcgc cttcgcaaac ccctgagcat cctcgagcgc 3018721 ccaatgattt tcccagtcat ataaaatcgc ggtttgagcc ggcctcttcg ttccgacaac 3018781 ttcggacagc cgttccaatg tctcgcctac cttggccact tcttgaaaga cgcggttctt 3018841 cgggctattg tcatgatcca caaccgctcc gtgtaatttt tctgatgacc cccgtgattt 3018901 gcggtattgg aaatagagaa cgctgtccga gccgtgggca atcatttgca tggatgacag 3018961 cagattcatg cccgggcgct ttgccttgtt gacgttatgc caattgaccg cgcttggcgt 3019021 acactccatt aataagaagg gctgctgctt caagcttcgg tacagatcat tgataaagcc 3019081 gaccttcatc gccaaatcag ctgtgctttc ccagtcattg tgccagacag gataagcgtc 3019141 ccagctgatg gcatcgacat gctttgcaaa tttgctgtag tcgaggccct gatacgggat 3019201 caaatccggt gtgtcagcca taaaattcgt tgtgataggg atatcaggcg tcaattcttt 3019261 cagcggaatg atttcatttt cataaaacga aatcgtttga tcggtgacga accggcgcca 3019321 atctaaattc aggccatgca agccattttc accgatcggc gaagggcttt caatttgtga 3019381 ccagtcattg aacgtatggc tccaaaaagg ggtccaccac gcatggttca atgtcttgag 3019441 gctgttgtca tatttcgatt tcagccactc ccggaaagca tgctggcata aatcacagtg 3019501 gcaatctccc ccgtattcgt ttgaaatgtg ccacattaac agcgccgggt gatgtccgta 3019561 tcgttctgct aataagcggt tgatgtgccg tgttttttct cggtagactt tagatgtgag 3019621 gcagtggttg tgccttccgc cgtgcagctg tttgacgcgg gaggcattga cgcgcaaaac 3019681 ttccggatag gtttgcgaca gccaggccgg acgggctccg ctcggcgttg ctaatatgac 3019741 ccggccgcct atactgtgaa tccgctcaaa aatatcatcc agccattcaa attgatatac 3019801 gccctcctcc ggctcaagtg cgctccatgc aaaaatgccg acagaaaacg tattcgtatg 3019861 agaaagcttc atcagtttga tatcgtcagc taaaatatcg ggccgatcca gccactgatc 3019921 ggggttgtag tctcccccat ggagcataaa ttttgctttt gttacgtgcg ttttttcaag 3019981 ctttgacatc acattctcct ccttgttctc ttagcccttc gttccgcctg cggttaatcc 3020041 ggacacaaaa ttcttttgca gcataataaa gatgacggca accggtatgc tgataagcag 3020101 ggctccggcc gcaaatgtcg tatagctggc ccccatgaca tcattcacta aattgaatag 3020161 accgacgggc aatgtatatg attcaggcgt tctcaatatg gttgaggaca gcacaaaatc 3020221 tccgagcgga ccggtaaagc cgttcatggc cacgactgcc gccatcggtt ttgataatgg 3020281 cagaatgatc tggaagaaga ttctggtgct gctggctccg tcaatcttgg cgctttcgtc 3020341 taaatccatc ggaatggaat ccatgtaccc tttcatcaaa tacgtattca tcgggatcag 3020401 gccgccgata taaagcaaga ttagcagcca gtggctattg atcattccca agatttgcgc 3020461 cagcacaaac aaggcaatta aagctgaaaa ctgaggaatc atctgcagca ataaaaagag 3020521 cgttaaagcg tatttcctcc ctttaaaccg aaagcgcgaa aacgcatagg ccgtaaacgt 3020581 cacacagagc aaagaccctg ccattgtaaa caggctgatc ttcatagagt tgacatacca 3020641 ctgcacatat tgaaggcttt ccttgcccgc aaataattcc ttgtaatgat cgaatgtcgg 3020701 atgcttcgga atgatggatg tactgattaa gctgttgccg ggattaaagc ttgcgcctgc 3020761 cgtccaaagg agaggataaa caatgatgac cgccataaag gctagcaaca agtaagagaa 3020821 aaggagacgg atatatcttc tgactttcat atctgccagc ataccttatg cctcctcttt 3020881 aaaagacttt gtctgtctga actgccacaa tgcgatggag ataacaaata cagataataa 3020941 aatggttaaa gccgcagcaa gtgaatattg gctggactgc attgtcaatt tataaatcca 3021001 tgaaacgagg atatctgtcc cgccggctgt tgatccggtt acagccggac ctccgccatt 3021061 gaatagatag ataatattaa agttattaaa gttaaacgta aactgagtaa tgataatcgg 3021121 agccattgca atgaacacca tcggaagcgt gatgtatctc agctttgaaa agacagaagc 3021181 gccatcaatc gtagctgctt catacagatc gtccgggatg gattgcaata cgcctgttga 3021241 gacgagaaag atgtacggaa atccgagcca gccctgcatg agaatcaatg caagcctcga 3021301 ccaattggca tctgtcatcc acggaagcgg atctatcccg aagaaagcca agatgtcgtg 3021361 attcatcgca ccgaagctat cattaaacag tcccgcaaaa attaaaatcg tcacaaaacc 3021421 gggaacggcc catggcaaaa tcagaatcgt ccgaaaaaaa cgtttaaacc gaaggtcttt 3021481 ctggttaaca atgatcgcga gaaaaatccc caaggtgact tgcagtgtgg atgcagcaag 3021541 tgtccaaacc accgtccaag ccagtacatc aaaaaaagtc gacctccaaa tatcaactgt 3021601 gaaaatattt gcgaacgttt gaaaaccgac ccaatcaatt aattttgcag gaggagaatg 3021661 atacaaatca tagtttgtaa acgctaatgc aaagctgaat aagataggaa agatcacggc 3021721 gaaaattaaa ataaacaaag atgggccgct gacgacataa ggatagccct cagaaatgat 3021781 atgctggtat tgttccttta aggaacttaa tggcttattt tcatcacgct gttttccgct 3021841 ttggaacgca tcgcgaagat ttacataata caccgcaagg ccaaagcagg tcacgatgac 3021901 agcaataatc ccttccgcca gcagaaaaac ggaattatcc cgcggcactt ctgttcccag 3021961 tgtaaagatt ccccaaaacc ccatattgag cagatctcca aagaccgcaa aaaacgatgc 3022021 gcctaagaaa agaaagacaa taccttttat ccattgcttg ttataaaatt gcccgagtcc 3022081 cggaatgata gaaagcaaca aagcgacttg acgatgctgc accgttttca cctctcttac 3022141 aatacaaatc tagctttctc tttattttcc gctgtgcttt gccttaattt gtcctttggc 3022201 cgtttcagct gcttgatcca atgcttgttt cggatctgcc ttccctgttg caaccgtctg 3022261 taatgctgaa tcagccggcg tccatatttc attcatttcc ggaatatttg gtgttggctc 3022321 tgagaaacgg gattgttcag taacagcccg tgccgcctcg cttttcataa tagccgggtc 3022381 attggctagg gatttcacag caggaacttc tttcgtttct tcatatcgtg ttttagaatt 3022441 tttttcattt gccaggaaaa cggctaattc ttgcgccagc tcttcattct ttgaaaatgc 3022501 actgacgttg tagcttttga cgccgataaa ggagctcatg tttttcccat tttccagctt 3022561 cggcagtttc gtaatgccat aattgattcc tgcattcgaa aaggcttcta cattccatgg 3022621 accagaaata attgcggcgg cttttccttc tgtgaacagc gattccaaca cgttaatccc 3022681 ttgttctcca ataatgccag ccgggaacag gccatctttg taaaacttct gaatcagcgc 3022741 cgcacctttg acagctcctt cattattgat tccaatgtct gacgggttat agctcccatc 3022801 tttggccttt ccaaaaatgt atccgccata tccgctcatc acactttctg cataataaat 3022861 ttgatcgaat agggctaaaa agccaaattt gctgccgtca gcagtctttt tggaatagtc 3022921 gtaccactct tccagcgttt tgggcaattc cttttctgtg atgagatctt tgttgtaaaa 3022981 aagcacagtc gtttcgaccg cttttggcag tccataaagc ttttgatcta ccatttgaga 3023041 ctgaatggaa gcgtcagtat aaagtgattg aacgtctttt ttgacatgta attccttgag 3023101 taatccttcc gtgacagcgg ttccgatttg gtcccctggc attgttaaca cgtcagggcc 3023161 tgtgccggcc ggtccatcca ttcgcaaatc ttcaatctgc ttggcatacg gtttttcaac 3023221 gactttgacc ttcacatcat gctctttttc aaatgcagcc acagcgtctt taatgccgtt 3023281 gctcttttct ttatcctccc atacaacaag ctctgaccct tttgaactcg atttggcgct 3023341 gctgctttcc tttgggccgc aagccgccaa ggataaactg acagctgcgc agagcatgaa 3023401 tacggaacac ttttttgcca ttttcattga ttgtcaccct ttcggtagga atgaaagcgc 3023461 tttaaagata atatagcatg cctgagaaaa tgtgtaaaca aactatttac ttcatagagt 3023521 aaattttttt acctaaataa aaaatgactt agtgtcctaa gtcatcctta attcatactc 3023581 ttcctgacga ttaattctgc gcccacatat aatgttttta ccgttcttct cttgtcctgc 3023641 acttgttcaa gcagtaattg aacagcgttt ttacataatt catgtatatc aatatgaaac 3023701 gtcgtcagag gaggcgagac atacttcgcg aagctgatgt tgttgatact cacaatgctt 3023761 accctgtttg gtatggcaat tcctttttcg ttcagggctt gcagacagcc cactgcaatc 3023821 gggtccgctg caatcataaa agcagtcgga agctgatcgc ctaatgtgtc gatcgctgct 3023881 gacatcaggc ggtagccgtt ttctacagag aatccgcgat gacagaaaat atagcgctcg 3023941 tccagcatgg ctttttccct catataggat ctgaaggttt gttcacggat gtccatttca 3024001 tcctgattgg tattcggatt tttgtatgtg ccgccgataa aaccgatgct cttatgcccc 3024061 ttctcagtca ggatgtttac cgtcttcctt gtcatttgtg ccaaatcggg ccttaccgag 3024121 tcaaaatgat cgggatcagg agttgaatcg atgaacacgc cgttttcagt gagatttctg 3024181 aggaaagcca gctcttcatc tgaaaatgtg ccgacggcaa taaacccttc cgtatgttca 3024241 ggaatgctct cgattccatc cgctatttta taagtggtca tatcgacatt gaatgctttc 3024301 gccagtttct ctacttctaa tctcatcgtt ttaaaataga catcttctaa ttcttcttta 3024361 tctgtcagcc aatataaaaa cgcaatatgt ttcaccagcg gccttactgt ttttttgcgg 3024421 taattgagct tttccgccgc ttcatagatt ttctcccgtg tctcatcagg aacagaaagg 3024481 ctttcatcgt tatttaaaac gcgggaaacg gttgagattg aaaatcccgc ttcctgcgcg 3024541 atatctttaa ttgtcgccat tgtatctgcc tccattattc agctcgcatt gttttagtaa 3024601 aatattttac tttctttttc acaaatgtca agtgcacaaa gccctctggc tgccatgtaa 3024661 aaagactgaa ccatttgcgg ctcagtctca gttgttcgta tcattcggaa ccggcggaat 3024721 tgcccgggaa atgagttggt tattgcacat tttcctcgaa atatcccgaa agcacatctt 3024781 ccacattcgt caaatgcgcc agcatggcgg cttccgcctg tgcaccgttc ccggcagcca 3024841 cagcattgta aatccgttcg tgctcctcat acagccgctg aacggaggtc ttcttggaaa 3024901 acagccagat tttcctcgtt tccctcattg tttccagcag caatgatgac acgtgattca 3024961 tcaagtgttt aagaagttca ttttgagaag cgtccgcaag cgcaagatga aatgcaaagt 3025021 ctgctttctc tcccagctcc ccgtccgctt caatgctgcc catttccttt agtgcatcct 3025081 gaattctttc gagatctgct tctgtccttt tttcagccgc tagtgaagcc acgccgattt 3025141 caagcagttt tctgacctcg agcagctgct tgacgtcctc ttttttcatc agaagggcgg 3025201 ctgagagcgg ctgagaaatt tgattgagct caaattcctt cagatacgtg ccttctccct 3025261 gtttcatttc gacaagcccc atcgctttta gcgcagaaag tgcttcgcga accgctgaac 3025321 ggctgacttg aaagctctca gcaagcgcct gaacagagtc cagtttatcc cccggcttca 3025381 attcgccatt tttgatcata tctaataggg catccgctac ttcttcatat atttttttgt 3025441 tttaatctgt ttatatttca atgcaattca ccccgtaact tgtaggtctg gctgtttacg 3025501 atctattata ctctgttttg tgggccgcca aaagattttg actattttgt caaaaagtct 3025561 tgtactttga tttttttcaa aatataatgc taggtaactg gtcttattac ccagtcatca 3025621 gatgatcata tcatctatag aaaccgctta catatggcgc cagtttatgt ttcaaggagg 3025681 ggtttgggat gcaatggaca caggcatata cgcctatagg gggaaatttg ctattatcag 3025741 cgcttgccgc acttgtaccg attattttct ttttttgggc actcgcgatt aaacggatga 3025801 aggggtatac agcaggcttg gccacattgg ggatcgccct tatcattgct gtattggttt 3025861 atcgtatgcc ggcggaaaaa gcgctgatgt ccgcgacaca aggagccgta tacggattgt 3025921 tgccgatcgg ctggatcatt gtgacgtctg tttttttgta taaaatcact gtgaaaacgg 3025981 gacagtttga tatcattcgc agctctgttc tctcgattac tgatgaccga cggcttcaag 3026041 ctctcttgat cgctttttca ttcggggctt ttttagaagg ggcagcaggc ttcggagcgc 3026101 cggtcgccat ttctgccgcg ctgctggtcg gtctcggctt taatcctctt tatgctgcgg 3026161 ggatctgttt gatcgccaat acggcgccgg ttgcctttgg ggcaattggg attccaatta 3026221 cagccgtaga agggccgaca gggattccgg cgatggagat ttcgcaaatg gttgggcggc 3026281 agctgccgtt tttatccgta tttattcctc tttatttaat catcatcatg agcgggttca 3026341 ggaaagcctt ggagatctgg ccggcgattc tcgtatccgg tgtttccttt gctgttgttc 3026401 aatatctcag ttccaatttt ttagggcctg agctgcccga tgttttgtca gctcttgttt 3026461 caatggctgc gcttgctgtg tttttgaaat ggtggaagcc gaaaacaaca ttccggtttg 3026521 ccggtgaaca agagtcggcc gcctcaattg aaacggcgcg cacaaatccg gcggcgcctg 3026581 catacagagg cggacagatt tttaaggctt ggtcgccatt tctgctgctg acggcgatga 3026641 tttccgtatg gggcattcca tctgtcaaat ccgcgctgac cgggcattat gaaggctctg 3026701 cggtgttctt gaagtggctg aatgctgttg gagaaaaact gactttttcc cccggtgtgc 3026761 cttttttgaa caatcagatt gtcaatgctg acggtacgcc gattgaagcg gtttacaagt 3026821 tggaggtgct tggttcggcc ggcaccgcga tattgattgc cgcagtgctg tcaaaattca 3026881 tcacggcgat ttcgtggaaa gactggggaa ccgtttttaa agaaacagtc caggaattga 3026941 agcttccgat tttgaccatt gcttctgtcg ttggttttgc ctatgtcacc aactcctcgg 3027001 gaatgagcac gacactcggg atgacactcg cgctgacagg ttcgatgttt accttctttt 3027061 cgcccgttct cggctggctc ggcgtcttca ttaccggctc ggatacttct gccaacctgc 3027121 tgttcggcaa cctgcagaaa gtcaccgcat tatcagtcgg catggacccc gttctgtctg 3027181 tggccgccaa ctcttcaggc ggtgtcacag gaaaaatgat ttcaccgcag tcgatagcgg 3027241 tggcgtgcgc cgcggtagga ctcgccggaa aggagtcaga tcttttccgc tttaccatta 3027301 aacacagtct gtttttgctg ctgctcgtct gtatcatcac ctttttgcag catcacgtat 3027361 tcagctggat gattccttaa aaaaatcctc ccgtctaggg aggattttat ttatatcgct 3027421 ttctcgctgc cgatgacgga atattcattt gatcgcgata ttttgccacg gtgcgtctcg 3027481 agatttggat gccgtgttgt tcatacagca aatcgacaag cttttggtct gaaagcggtt 3027541 ttgttttgtc ctcttgattg atcaggtttt ccagatgcgt tttgactgca taattcgacg 3027601 catctccatc acctgaagcc tcggcttttg ctgagaaaaa gagtttcatc tcaaacagcc 3027661 cgtaaggcgt ttgtattgtt ttccctttaa tggcccggct cacagttgat tcatgaaggc 3027721 ttagacagtc tgccacctct ctgagagtca gcggcttcat tgcgcttcgc cctttcagaa 3027781 agaaatcctt ttggcgtgtg atcagttcat tgataattct cgtgattgtc tgttttcgct 3027841 gccgcagcgc gcggctcagc cagcgccact cctgatattt cgcagataaa taggagacag 3027901 tatcctgaca ggagccggat gataaaagcg ttctgtactg cggatgcaga tcgatctcgg 3027961 gaaacgagcg ggtattcagt tccgctgcga tgtgcccatt ttttacggtg ataaaaatgt 3028021 caggctcaat atacacatct tgctctggcc gggcaaacag aaggccaggt ctaggatgaa 3028081 gagccgcgat atcatctgag atatcttgaa tggtatgaag cggaattccc gtctctactg 3028141 aaagcgtttt ccattttttt tgcgcaaaag catcaaaatg agctgaaacc agcatttccg 3028201 cttgttcatt tctgttcggc agccgctgta attgaagaag gatgcattcc tgcaaagatc 3028261 tcgcgccgat tccagccggt tctaacgact ggagttttgc caaaacagcc tccgcttcct 3028321 tggccgatac agataatcgc cgtgctgcct cctctatatc ttcttccaag tacccgtttg 3028381 aatcaagcga atgaatcaga taattaaaaa tctttttttc agtgtttgtc agattcatat 3028441 cgagtgactg ctgttttaac gcatcctgca atgttttttg cggattactt aattgaaggc 3028501 ccgcttcctg tgcattcatc ctgtttttgt ttgttttatg gtaagatagt ggcggtgtgt 3028561 ctgtttcctt tcgttcaata agagggtttt ccagtgagag ctcatcaatg tactcggcga 3028621 gttctgccga atgatagcca agcagcgtga tggcctgcct gagctcctgt gtcagttgag 3028681 gctttaatac ttgtacttgc tgaagtttca tatccatctt gctcactccc ctttcttcat 3028741 tgtacatgat tgagatcaca ccgtatacat ttatgaaaaa ggagctgcca aagaaatgtc 3028801 tgaacttttt tccgtccctt attttattga gaatttaaaa cagcatattg aaatgaatca 3028861 gtctgaggat aaaatccacg cgatgaacag ctactaccgt tccgtcgtct caacactagt 3028921 gcaggaccag ctgacgaaaa acgcagttgt cctgaaacgg attcagcatt tagatgaagc 3028981 atacaacaaa gtcaaacgtg gagaatcaaa ataaaccttc cgctcacatg tgagcaggaa 3029041 ggttttcctt ctttgaggcg tgctggatga gacgggtgct tggcacgcct tccatccagg 3029101 tatgaaagta attggcgttt ttcccgtagg aattatcaat gaccgtgttt tctttttgaa 3029161 gaagagaaga caggatgtgg ccgtgcagcc ttgatgtttc caccgattcg taacggctga 3029221 aaaaccgaat cgctttttgg acgatataat ccgagtattt ttcccatata tacgcaatgg 3029281 gcaaagggtt gcctgctttt ttattcaaga cgttcagcgt ttggagaaaa gcaatcgtcc 3029341 ggcggtctga agctgacagc accgtgcgcc agtcgtagct ttccgcttct gcgtgttcct 3029401 gaagcgcctg gtttgcttca tgatctgttc ggataaatct cagcttttga ttggacggct 3029461 gctgcgtggg aatgacggga aacagctgat gagccatatc aggcagaagc tgaatgtgat 3029521 ttgttgtaaa ataggcctgt gccgtagcat aggaggcttt ttcccttgtc atgatgtgaa 3029581 ggttcgcatg cttagaaaat atctctgccg tccgcttgag gttgtctttg ttttgaaaat 3029641 aaatcgattg cggcaggatc acaattttgt ggttcggata ggtttggacg attttctctc 3029701 taaagccttg ataatacgga tacagatccc cgaagtttcc gcctccctgg cagacgatga 3029761 tgagattcgg atcaagcttt cgcccgattg ggaaattgtc tggattccag cgttttctga 3029821 cccgaatccc gtgttcttta aagaaggctt ctgttccttt cataataaat aaatccccta 3029881 cattcccata tagaggatag tcagcatata taatctctga ttgtttcgga atgacgtcga 3029941 gcagcccgga cagtttctgt ttcaggctga tcatcgaatg cttgctgtcc atttcttcac 3030001 ctcgacagta tggaataagt gcagtagcac ttcaatgacc cggccttgct catcttctgt 3030061 catattggac cccgatggga gacagattcc tcgcttgaac aaatcttcgc atacgcttcc 3030121 tgtatcttca tgagaataaa ataaagccgg atcgaacagc ggctgggtat ggagcggctt 3030181 ccacagcgga cgggcttcaa tgttttcttc agcaagacgt tgaactatgt catatgggct 3030241 gagcccgtta tcaagtgtga gcgtggtgag ccagcgattg gatacgcctg ctgcgtactc 3030301 tggcataaag cggacgccgt ctaagtgacc gagcgcattt ttgtatctcg tgaaaatggt 3030361 ccttcttttc tccactcgct catccagcac ctcaagctgg gcaatgccga cgccggctaa 3030421 gatattgctc agcctgtaat tatgtccaat ttcactgtgc tgataatgaa cagccggctc 3030481 tcgtgcctgc gaagcgagaa atcttgcttt ttcaattgcg gcttcatcat ttgaaacgag 3030541 catccctccc cctgatgtgg tgatgatttt gttcccgtta aatgaaaaaa tgccgaagcg 3030601 cccgaatgtt ccgctttgct tccctttata gactgtgccg agagattcgg ctgcgtcctc 3030661 aatgacagga actccgtatg catcacacag gcttacgatt tcatccattt tcgcgctctg 3030721 cccatataga ttgacggcaa ttaccgcttt tggcagtgtt ccgtttcttt tcgcttcctc 3030781 caatgctctt tcaagggctg tcggcgacat attccacgta tcaggctcag aatcaataaa 3030841 gacgggcacc gctttttcat atagaatcgg attggcggtt gctacaaatg tgaaggactg 3030901 gcaaaacacg ctgtcacctt cttttacctc aagcaaacgc agcgcgagat gaatcgccgc 3030961 cgttcctgag ccgaccgcag ctgctgcttt tacaccgact cgttctgcca gctgttcttc 3031021 aaatgaattc acgagcggcc caagcggcgc aatccagttt gagcgaaagg cttctgaaat 3031081 atagtgctgc tccctgccgc tcatatgagg gggagataag tagatttttt tatgcataga 3031141 atcatccttt gtttgatgtt tgaatggaag aaatgatgcg tgccggagca ccggccgccg 3031201 ttaccctgtc cggtatggaa cggatcaccg cggagccggc tccgacaatg ctccaagccc 3031261 cgattatgat ctgcggtatg acggatgcac cggttccgac gtgagcgcct tcctgaacgg 3031321 aaaccgctcc tgacagcgtg gcacgcgggg acagatgaac gtaatcgctg atttgattgt 3031381 cgtgctctgc cactgcaccc gtattgatga tgcagtgggc gccgatgcgc gcatccgcct 3031441 gaatgatcgc gcccgccata atcactgtcc cttccccaat gacagccgac ttgctgacga 3031501 tggctgacgg gtgaatcaat gtaataaaat catctttccc cagtcccagt cgctccgcca 3031561 gctgttttct gacactgtta ttcccaacag caatcagaaa cagcacatca ggaatgagcc 3031621 tgcgcagttc agtaacggct ttcggcggtc ctgtgtacca ttcttttccg ccttcgaacg 3031681 ttttgaattt atcatccagc accgcggcta agcgcgtatc tgagcgggcg tttatcagct 3031741 ctctgatcac ctttccgtga ccgccgtcac ccacaatggc cacatttttc atgaggacac 3031801 atctccgctt ccggtaaacc gttccgcggt cacatgattg gtttgctgaa tcccttctga 3031861 aacaaggacc tttcgcaccg tcaaacataa aattttcaaa tcgagaaaaa atgaccagtt 3031921 gtcaacgtac caaacatcta attcaaattt cttttcccag gaaatcgcgt ttctgccatt 3031981 gatttgcgcc cagcctgtga tacccggctt cacctcatgg cgccgtgcct gtttttctgt 3032041 ataaagaggc agatagtcca tcaaaagcgg ccgcggcccg acaaggctca gatcgccctt 3032101 caggacattc aggagctgcg gaagctcatc aatgctcagc tttctgatca gcctgcccgt 3032161 tttcgtcagc cggacttcat caggcagcag atttccttta ctgtcccgtt catccgtcat 3032221 tgtccggaac ttatataggg tgaacggttt gccgtgcagg cccggcctta cttgcttaaa 3032281 gaagacaggt gatcctattt tcagcctgac aacggcgatg gtgaacagaa tgatcacact 3032341 tgtacagcac aacaaaaaaa tggcggccgt cagatcaaaa agtcgtttca ggatcaaaga 3032401 ttcacagctc ctttcgtttt tcgaaaccgt tttaatacca gctgtctttc ctcttttgta 3032461 caaacgagca taaaagcgaa aacagcgtag caaaagctga ctgtcactcc cgtcgctatc 3032521 aatgacggcc agctgtcaat cttcacaatg aactgaattg ccttacagac cgtccaggca 3032581 aatacagcgg ctgaaagagg cccgattatg cctttaagga acacgtgctt tttgtagcct 3032641 gtaatgcggg atacgtaaag cggcgtaaag atggcatttt ttaaaataag agaaatggcc 3032701 cctgccaatg ttatgccgta cagaccgaga tgagccggcc cgctcagcgt gaccgccagc 3032761 accacattca ccgcacctaa cagcagggta acaatcgccg gtgttttttg ttgattaaaa 3032821 gcggtccata tataaaacag cggcataaag gcgaggctga caaccaagta tccggcatga 3032881 ataaataaaa gcggtgctat cgttgaaaag gacggtccga gccagattgt cagaaaaggt 3032941 cccgccaatc cgcccaataa ggcagcagga agtgcaagca aaagaccatt gagccttact 3033001 gccttattgg cgtaattcat caatccttcc atatcgcctt ttgaataata tgaagtcatg 3033061 atgggcgcaa acagggatgc gaccgttccg gccaagctgc gcaaaagcag cggaaactgg 3033121 ataatcgccg cgtatttccc ggatgcagac gcccccagca tcaaattggc ggttaacaga 3033181 tcaatctgca aaaaaagcag gacgccgatt tgattgacgg agctccatgc gcccgcttga 3033241 aacagctcct tgcttgtacg gaatgaaaga tccttcatac gaaacgaaaa ccacggaatc 3033301 agctttttga agaaatagaa agacagcaca gacgcaataa cagcaccagc taaagctgca 3033361 agctggatct gccagatttt cggcgcaaag catgcaaaca ggagcagcac agacagcacc 3033421 cgtataagca tttgcaccgc ctgaatggaa ctggtgatat aaaggcggtt ggcataaaat 3033481 ggtgcagcgc cgaagcccgc catcagaaac gttaaaataa acagcacact gccgattaaa 3033541 atcgacaaac gcacatctgc caaaagcgct tgcggcacat tcatgacgcg gtcaataaaa 3033601 aaagccgaac ccgcaagcgg cagcaagagc agcaaggaaa tcaaaacaga ggcggctaaa 3033661 taattgctga tatacgcatt tgctttctcc cgctctcccc tgtgggcagc aacagaaaag 3033721 aaccgaacga caaccgagct gagcgccacg gtaataaccg aaaagtaatt aatcacattt 3033781 tgtgtcaagt gaacaaagcc aaacgcttcg acaccgagcg ttttgacaat aaaaggcgtc 3033841 atccaaaccg ataggaaaac agacaagaga aaagccgtga gattcgcgct gaaatttatc 3033901 gtgaatttca tgcctgcttc gcactgcctt tcattgtccc ccgctgctcg aaaaacagct 3033961 tgatgagaaa agtgagccgc catttacaca gtgctaatac caaacgctct cctcttaata 3034021 atttctcatg ctgaaacggt gtatgtctga cagcctgccg caccatgtca taggataaaa 3034081 tctgtctgat cttctttttg atgtctttcg gcgaattcgg agaagcacag gcatttgcca 3034141 aaagcatcgg aagctggtgc ctgcaaatgt acacattcaa atcttcttta catgcgcctg 3034201 ctaagccgta gtgattgtag aatgcgattt tagcctgata ttgtttttga agatgttcat 3034261 ccatcgccgg cttataaggg atttctgtca ggctgttcgg gttttcacga taaatgtaca 3034321 atccttcatc aagcattttc acccgctccg cttcgcgaaa agcggacaaa ttaaagggag 3034381 agtcttcagc aaaacggatg tcttcatcaa acagcagatt cgccctttca aaaagctcac 3034441 gacggtaaag ataacgccat acataccaga taaatctcgt ttcgtgagca tgtttaagct 3034501 gttcagtcat ttctggtttc gtcagcacgc ggtttgcctc aagctgcggc ggcacatatg 3034561 tccgcctgtc cgatgactgc ttgtaaaaac cgcatccgac gatgtcaagc tgattttgct 3034621 ccgcttcttc agtcagcctc tggaacatgg cggatgatac ataatcgtct ccgtctacaa 3034681 agccgatgta agtgccccgc gcggccttta ttcccgtatt tcgcgctgaa ctaagcccgc 3034741 cgtttgcctg atgaatgacc cggattctcg catcccgttt tgcatagtcc tctgcaattt 3034801 cgcctgaacg atccggtgtt ccgtcattca cgaggatgat ttcaatatca gaaagcgttt 3034861 gacgaagcaa agaatcaatg cactcttcta taaatggttc aacattatac atcgggacaa 3034921 taatgctgac gagcgggatc attgcgcttc accgctgatt ttgtcacgca gacctttaaa 3034981 atacacatct ctcggaaagc ctgcacggga tgtttctttt gttaaaagct cattgactgc 3035041 ggctgttacg cgctctggct ccggatgttc tatcagcttc atgaacggga tgtctttaag 3035101 ccattgatag ccctccatca ccttatggtc aaaggagcga atgacaacac acggcgttcc 3035161 tgtcagcgcg caaaaaatca tgccatgaag cctgtcagtg acgacggctt ctgcgctttg 3035221 cagcttagac cacagtgctt caagttcatg ttcgcgtgta tcgcggctga cccggcggcc 3035281 gatcgttgtc gtaaaggatt tgatctcgcc gaattcctca catagcgcag ccttgacccg 3035341 gttcctctgc tcctcctgaa gcacgctttc ctgatcctcg cgcaaacaca tataaacccc 3035401 ttcgcgttct gcgggagcct tgcttctgtc taaatacagc accatgtccg gctgcttcaa 3035461 aattgttttt tcttgaaaat gctgtttcat aaattgatac gttgtttcat cccgcgccat 3035521 cagcaatagg ccggggtgcg cattataaat tttctgtgcc cgtttcagct ctttgcgccc 3035581 ttttttcgtg tcagaaaaat gagccgttgc cggaagctgg acaacccgat agtcatggaa 3035641 tgttttaatg atgaagcggc gcgtccactc ctcataacgg tataaatccc ccatgtttcc 3035701 gccgccgatg ataaagacca tatcctccgg atggcgcgag cggatcaggc tttttgctga 3035761 tttgtaaatg tccttcatat cgacctcgac gatgtcaaag tccgggtatt cttgctcaag 3035821 aaatgccttg ctggcataag caattgcgtg atctcccaaa ttgtcatggg acggcagcag 3035881 ggtcagtatg atttttttct gatgtgctgc ggcctttacc ggttgatctg ccgctcccag 3035941 ccaatattgg gacgggtatt tgacctttag cagcagccat tctgcaaaat tgattttcaa 3036001 cgattgtaac gacatgtcct caccctctgt ttctcatttt gtactcgatc acccgctgat 3036061 acacagccga tgccatagcg acgaacggaa tcattctgta tttcgccatc agaagcaggc 3036121 atgaccgttt tgcgtcaaaa ggagcagtac ccgtttttga aagactttct tgaaacaccg 3036181 ggtccgcgca tatcacgcca acatttctaa gcttttcaaa cagccggcgg ctgccgctcg 3036241 ttttccattc attcagcata cagatgctgc tgtgaagaac gataaaggta tcaagctcct 3036301 tgcgatactc ctccagtttg ttgttctcct gtaaaaacgc cgcattcgtc tcatacagcg 3036361 caagtcctga ttcaaacaat tttttctgat agcgctgcac aatggaggaa aggtgaattc 3036421 gataatgata gagcggcgtt tttacgtagg atactgagcg ggcgaaaaaa tgagccctga 3036481 agctgaaaaa ctgatcctcg acatgctcca gctcgcctcg gagcggaaac gacagccgat 3036541 gggcttcaat catgcttctt ctgtacagtt tgttccatga aaaccctctg accttccctt 3036601 cgaataacgc cttgatatag tgctccttcg gctgatcctg ataggtttgg gcaatgtcag 3036661 agtccatggt tttgccagtg tcctcaaact ctgcggcgta attgcaaatg accagatcag 3036721 tttcatcgcc tgctgtccgg agcatctgct cgcaataatc aggctcaatc caatcgtctg 3036781 aatcgataaa cgcgataaat tcgccgcgtg cagcttcaat gcctttattc cgaaccgcac 3036841 cgagtccctg gttttcctga tgaatcacct tgaacctgtt gtccattttg gcgtattctt 3036901 ctgcgatatc cgggctggcg tcagctgaac cgtcattgac aatgatgatt tcaatattgt 3036961 ccattgtctg gttccgcagt gattcgagac acgttctgat atatgtttct gtgttataaa 3037021 cagcgactaa cagactaacc gcaggtgttt ccataatgac cggctcctcg tgcataaatt 3037081 accgggaaaa aatcgttctg taaggcagaa ccgatgaatc gaccggcata agcaaataac 3037141 tgtaaagaaa ataacaaaca acgatagcga tatagataag agcgttcgat ttttcatcaa 3037201 atatcctgac gaaataaggg actaggatca tttgatacag accgaaataa atattgaatc 3037261 tggcaaaaat cacgtccttt gtggccaaaa ggccgaacaa aaaacctagc aggcacaaat 3037321 tgacgacaat atcaatttgc ggccacagac tccgcagtcg ttctttatag caaaatgcaa 3037381 ggaacagcgg cagaaccaaa acagcgattt tgatcacatt cattccattt gtgttcgtca 3037441 tgagccattt ttcataatgg ctgtatgagc tgttttcaag tacaacgaca aacacagaaa 3037501 taaatttttg atataaaaat gtcatgccga gaaataaagc ggataggccg aatatcgccg 3037561 gtgaccaggc ttttcttctg acaataaagt acactggaat cataatcagc gccgacgaat 3037621 gaaagagcga gctgaccagc acaatcagga aatatcgctt ccagttcccg ctaatgatat 3037681 aacggatcgc ccaaaacaaa acagctgcca ccatgtattg cctgatgccg ttaaaagatg 3037741 cgtaataatg aaaggttccc aaaaataaaa agacactcag ctcaaacggc ctgccatagt 3037801 cggcgagtgt cttcataata aagctgtagg tcacgaccgc caccgtaaaa tacatgattt 3037861 gaggatcttc cgtgatgaaa ttcatcagcc aaaggagtgc ggtaaacccc ggatctgtcg 3037921 ctgttttcgc tgtgccgaaa ccgaatatct gccacacatt ttgataatcg cccgccaatt 3037981 cgtacaacag cgtgtacgtc tgaaaatccg tgccgactcg atagcggaga cctgacacga 3038041 gcacaagtga agcgagcgga atccagatca aaagcttatt cggccgatac cccgtggcaa 3038101 gcgaatcatc acggccgccg cacattttag cgaaccaaga ccaaataaat acaatcccca 3038161 tattgacggc atatacaatc atcggttatg gtccttttcc gtgctgatgt tgtatacatt 3038221 cagcagcgct cctacatttt gctgtgcatc gtagccaagt tgagcgagtg tttctttgat 3038281 gaactcacgc ttcggcctgc ctgcggcggc cgcccttgca atggtttcag cccagacgct 3038341 gatcggctca gaaagactta atcttgtgac aagcccgaga ccggcgtcga ctttttctgt 3038401 aatgctgtct gaaatgatgc atggaagccc cgacgcctgc gcttccacaa gcacaaccgg 3038461 caagccttcg tacagagacg gcatgacaaa tacatcgaat gttcgcatca gttcatggat 3038521 ccgttcttcc gtgcctaaaa agaggacgtc tgatagcaaa ttctgctgcc gcgcctcctc 3038581 ctctatctcc ccgcacaacg gcccgtctcc cgccagaacg agctgaaagc gaatgcctct 3038641 ttccttgaga tgtgcggcaa gcttcaacag gaacgcgtgg tttttcactt catgaaaccg 3038701 ggccacatgg ccaatgatga gccggtcggc tgcaatgccg cgtgctgctt tttcttcatc 3038761 agccgcctgc ccatttgggg cgaacaactc aaggtcaatc ccgttaggaa gaaggtgaac 3038821 acgctcccgc tccatattgg actgtccaaa taaaaacctg cccgcatcct ctccgcaggc 3038881 acacagcgct gtcgcatttg ccaaaatgag ccgcctgaac acgagcagct gcaatcgatc 3038941 cttccagttg aagccggtct tccaagacgt attgtgggag tggcataccc tgaccggcac 3039001 tccggcgagc cttgccgcaa gggcgataaa acccgtttgg aaatccgtgt gcgcatgaac 3039061 ggcgctgaac ggcccatttt cttttatcgc gtttctcaca ttcctcacaa atgtaagggg 3039121 attgctttgc ccaatgctcg ggacataaaa aagccgcccg cctaaagata aaatctcttc 3039181 atcataagcg cacggatcat ttcgatacgt taaaaaatca aattgcactt tgcttttgtc 3039241 catcttccga tataaattca ttaccatggt ttccgcgccg cccctgttca tgccgctgag 3039301 aacatggagc acgcgctttt ggctgctatt catgcttgac aagcccttcc ttttggttca 3039361 tcactctttt tttatggtag cgattcatca cagctgcagg cataaaggcg cgaattaacg 3039421 gttttgcgat atatatgtaa tcagataaag gaagcttcaa gcgtctgcac gcctgataga 3039481 caagaatggc attgtcgatt gaatacgtaa atgaccgccg tttgaatgca tcgctgtctt 3039541 ccctcacttt atacaaggct tcctgaagat tatagcccct gaagccctct tcaaaaaagc 3039601 gaagccacaa atcaatatct tccattcgtc tcgtccgccg caccgaccgg tagcctttca 3039661 gcgtgcggta ggcactcgct ctcatcataa tcgtgccgtg gcaaaatgga gtcccttttg 3039721 ccatgatgcc cggctccgga acagaaggca gaatgcgggc gcctcttacg ccaaattcat 3039781 caaacacaag catgccggtg ccaaccacct gatagtgtcg gtgcttttct aaaaacgcga 3039841 cctgcttttc cagacggcgc ggaaacgaaa ggtcatctcc gtcctgacgt gcgatataat 3039901 cgcctgtcgc atgcgaaaga caatgattta atgatgcggc aagccgctta tttgttttgt 3039961 tttgaatcag tttgatgcgg tcgctgtaat gagcggcata ctgcttcgcg atacggagcg 3040021 tgccgtctgt tgacgcatca tcgcacaaaa tcagctccca atttttatag gattggctga 3040081 gtatggattc tatgctttct gccaaagtgc gttcgcaatt ataaatgccc ataatgacag 3040141 aaactttcgg tcctgagttc atacgctttt ctcctttgta tccatatcca tgtacgcgga 3040201 ataaatatct gccatttctt ccaccgttcg cgcctccgag aagcgcaagg ctgtttttcg 3040261 gccttcctgt cccagctttc ggcagagctc cggcttatgg taaagctgtt caatccggcg 3040321 ggcaaaagca gcactgtcac cgattttgat cagaaaaccg ttttctccgt cgcggatgat 3040381 ttcccgatgc ccgcgattat ctgtggcgat cgccggttgt tctgccgcca ttccctcaag 3040441 cacattcata ccgaggcctt ctctaatgct ggatgcgaca gatacatccg caagctgaat 3040501 caactcatgt atgtcgctgc aaaagccgta aaaacagaca tgggcggagg caccaagctt 3040561 ttcagctaac gtttgatacg tatgttccat tgccccttcc ccggcaaaca caaggcggag 3040621 tgagggaatt ttttctttta gcaaggctgc ggcttcaatt aactgcttct ggtttttgtt 3040681 cagattgagc tcagccggat aaaccaatat aaaatcatct tcacggaacc cgtgcttttc 3040741 tctgagtctt tgctgctcta tcggactgac aggccggaaa cgctcggtat tgacgccaat 3040801 gccgtgaatt ttctgcgtcc ttccgcccgg cctttgaagt cctttcgccc gtatgtaatc 3040861 ctcttcatta atcgtaatca ggcagtctgt atatgctgaa agccatttct caaccggata 3040921 gtaaagaagc caatttttca tcggtgcccc tttgcagaag tgaaatccgt gcgctgtgta 3040981 cagcaccttt gttccgtgcc gccgtgcctg cctcgccgcc agtctggcga gaacgccgcc 3041041 gaccggtgta tggcaatgga caatgtcgta ttcataagtg tcaatcactt tcttcagctg 3041101 cctataaacg gccaggttct gagggtcaaa aggtgacctg cgaatcggga tggagaattt 3041161 ctcatccaca tacggcagct tggtttgtcc gttcgcggcg acatgaacct cccagcccat 3041221 ttgcttgaac catttaaaat aagggaggtg aaaggcctta aaatgataat caacagtcgc 3041281 gcaaaacaat atctttttcg tcattttcac tccccctaat gaacgctggc agccgtcatt 3041341 tcttctgatg tattgattgc cgcaaacagc ctcgctctca ggtcggcttc cggcagctca 3041401 tgaaaatcct cgataaagcg catcagcacc ggccaatcgc cgtccaccgc tttaccgatg 3041461 tgaatttttg gaaagatttg ttcagcatgg acttcatttt tgttcagcaa ttcttcatac 3041521 attttttcgc ccggacgaat gcctgtgaat tcgattggaa cctgctcagt cgtgtagccg 3041581 gacaaatgaa tgaggttttt ggcaagatcc acaatcttta cgggctctcc catatcgaga 3041641 acgaaaattt gacgcccttt cgccagtgcc ccagcctgaa tcacaagcct tgatgcctcg 3041701 ggaatcgtca tgaaatagcg ggtcattgcc ggatgtgtta ctgtcaccgg gccgcctttt 3041761 tcaatctgtt ttttgaaaat tggaatgacg ctgccgcggc tcccgagtac attgccgaag 3041821 cgaacagcaa caaatttggt tctgctgact ttcccaagat tcataataat catctctgcg 3041881 aatcgttttg tcgcccccat tacgttggct gggttcaccg ctttgtccga tgaaatcagc 3041941 acgaatgtct cagttcccga catatcggct gcttccgcga cattttttgt tccgataata 3042001 ttgtttttga ccgcctcttc tggattgtgt tccattaaag gcacatgctt atgggcagct 3042061 gcatgataga caacatgcgg ctcgtatttt ttcatcaagg taaacatttt atcgcggtcc 3042121 tgcacatcag cgatttccgt atggaacaca atgtgtttgc cgaatcgtcc gttcagctct 3042181 gtataaatcg aatgaatgct gttttcccca tggccgagca gaatgatttc cttaggctga 3042241 aacgcgctga tctgacggca gatttccgag ccgattgatc cgcccgctcc cgtgacgaga 3042301 actgtttttc ctttgatgcg gttcgaaatt tcgctagtgt cgagggttac cggctttctg 3042361 ccgagcaagt cctcagcttt tacatctctg atttgtccgg cagttcgtgt gccaagcagc 3042421 atttcatcaa aatgaggcat aattttaatg cttactccgg ttcgcacaca ttctttatat 3042481 aacacctgaa gctcatgggt gcggagtgaa ggaatggcaa taataatata attaattttg 3042541 agcttttgca ccgcaggcat gatactttct tttccgccga ttacgggcag ccccataatt 3042601 tctaatttat gcttcgtttg gtcgtcatca ataaaagcga caggtatgat atcaggttca 3042661 tctttcgaaa gcagctgcct gaccatcaga gtcccacctg agcccgcccc gataatcagc 3042721 gcgcgggacg aggcgcagcg ttttttcctg atgctttcgt ttaatactct ggataaaata 3042781 cgggtccctc caatagacaa aagctgaagc acccagcacg cggttaacag acggaagaac 3042841 atcgtgtgat acacagcata ctgaatgacg ccggtcacag cggctgaaag cgtaatgccc 3042901 ttaagcagga caatcagctc gccaagcccg gtgtatgtcc acacctgttt atactgattg 3042961 aacaggaaag cacacacatg atagctgagg agcaagctga cagcggtaag cagtaatgct 3043021 ccggagtcat aaaattgata ggaatctttt aaaaattgat atcctgcaat aactgaattt 3043081 aaaacgaggt aagtatccag cgcaataatc attgacagtc ttctccggta actcaacctt 3043141 ttccccccta attcttttat cggtttagct gcggcggttt tcgtctctcc aaaaaatcgg 3043201 cagcagctaa accgacaata cgtcctatgt atatatgaga taagtgggca tttaacccat 3043261 cctcacgccc cgccagcgac gaccagcatc taaggcagca acttcagctg cccacagcag 3043321 agccgagtgc ctccattgat acaggtcagg agacatcacc tttacaaaaa ctagtaggaa 3043381 tagtgttccg attttttcat tttctttttg tttaaaagag cgcctaacag cttcgcattg 3043441 gattgttcca gtgcatcttt tgctttcaga acggtatcgg tttttgtttt tccgcttaaa 3043501 acgacgagca cgctgccgtc tgtctgattt gctagaatct gagcatctgc aacagccaaa 3043561 agaggagggg aatcaaagat gacgaggctg aattgttcat agatctcaga tattaaatct 3043621 cccattgctt ttgaagacaa cagttctgcc gggtttggcg gggtcggccc gcttgtcagt 3043681 acatataagt tatcgatcgg cgtcttttgc accgtctcac tgagtgaagc attgccgacc 3043741 agcacatttg tcagcccggt tacattatca acctgaaacg tctgattgat ggtcggcttt 3043801 cttaaatcgg catccaccag cagtactttc ttttcctgct gctgcgcaaa gacagccgca 3043861 agattcgctg cactgaacga tttaccttca ccaggcacag aggaggtgac gaggatagat 3043921 cgcaagttgg tctggacaga tgagaactca atgtttgtcc gaatggtgcg atattgttcc 3043981 gcaacaactg atttattgtg taaaacagat atttgagcca aacctcgcct tgctttcttt 3044041 tttctaaaga tcactcgctt cactccccga aatgttttat cccgcgattc cgccctttgt 3044101 ggacatcagg aacggagcct aagcatggca atccggttct ctcgctgagc tgccgtgcgc 3044161 ttttgcatgt atcatcgaga aaatgcagaa aaaatgccag tgtaatgccg cccatgacag 3044221 cagcgccaaa agccatgacc atatttcgca gcctggccgg cttgatcatc gggctttccg 3044281 aagccttcgc ctctgataat atatgtacgc cttgtacatt cattctttca tctacttctt 3044341 tttcaaactt gttcactaac gtgttcgcaa tctcagctgc tttcgccgga tcgtgatcct 3044401 gaacggcaac gttgattatt tctgattcat tttcactgct ggtaaccact tttcctttca 3044461 gcgaggaagc cgattcagat aggtgcaatt ccgccttaac ttcttccatc aaggcagtgc 3044521 ttttcataat cgattggaac gtgctgctat actgaagatt tcgctggatg tcactgagat 3044581 tcgagttttc ttcaccgtct gattcatgaa ccagcacctg tgtcgacgcc tggtaggtcg 3044641 gtgaaatgac cttaaattgc acaaaaccca taataagggt gacgccgatt gtgatgagca 3044701 gaatcagcac gaatctgtgt ctgacaatcg catataattc tttgaaactc atattctcat 3044761 tcatgtattc atagccttca gccttcccgc ggctggcttc ccgcgcccct ttctgttaat 3044821 gattggatta taaaagaaaa cgttattatt taaaaattgc aaaataagcc aataagttct 3044881 ctttagagaa caaaatcatg attttcctct aatttactgc acttccctta ttattttaaa 3044941 ttttataaag aacgaaaaat tccttataat gaacgaaata acgacaggaa tagaggagaa 3045001 tttcatatta tgattggaag aattatccgt ttgtaccgta aaagaaaagg ctattctatt 3045061 aatcagctgg ctgttgagtc aggcgtatcc aaatcctatt taagcaagat tgaaagaggc 3045121 gttcacacga atccgtccgt tcaattttta aaaaaagttt ctgccacact ggaagttgaa 3045181 ttaacagaat tatttgacgc agaaacaatg atgtatgaaa aaatcagcgg cggtgaagaa 3045241 gaatggcgcg tacatttagt gcaagccgta caagccggga tggaaaagga agaattgttc 3045301 acttttacga acagactcaa gaaagaacag cctgaaactg cctcttaccg caaccgcaaa 3045361 ctgacggaat ccaatataga agaatggaaa gcgctgatgg cggaggcaag agaaatcggc 3045421 ttgtctgtcc atgaagtcaa atccttttta aaaacaaagg gaagatgatg atcggttaaa 3045481 gggctaacgt tcgcatctat aggggaaatc tgtttataat gggggaaaaa gggagagaac 3045541 acaatgactc atcaaatagt aacgactcaa tacggcaaag taaaaggcac aacggaaaac 3045601 ggcgtacata agtggaaagg catcccctat gccaagccgc ctgtcggaca atggcgtttt 3045661 aaagcacctg agccgcctga agtgtgggaa gatgtgcttg atgccacagc gtacggctct 3045721 atttgcccgc agccgtctga tttgctgtca ctttcgtata ctgagctgcc ccgccagtcc 3045781 gaggattgct tgtatgtcaa tgtatttgcg cctgacaccc caagtaaaaa tcttcctgtc 3045841 atggtgtgga ttcacggagg cgctttttat ctaggagcgg gcagtgagcc attgtatgac 3045901 ggatcaaaac ttgcggcaca gggagaagtc attgtcgtta cattgaacta tcggctgggg 3045961 ccgtttggct ttttgcactt gtcttcattt aatgaggcgt attctgataa ccttgggctt 3046021 ttagaccaag ccgccgcgct gaaatgggtg cgagagaata tttcagcgtt tggcggtgat 3046081 cccgataacg taacagtatt tggagaatcc gccggcggga tgagcattgc cgcgctgctt 3046141 gctatgcctg cggcaaaagg cctgttccag aaagcaatca tggaaagcgg cgcttctcga 3046201 acgatgacga aagaacaagc ggcgagcacc tcggcagcct ttttacaggt ccttgggatt 3046261 aacgagggcc aactggataa attgcatacg gtttctgcgg aagatttgct aaaagcggct 3046321 gatcagcttc ggattgcaga aaaagaaaat atctttcagc tgttcttcca gcccgccctt 3046381 gatccgaaaa cgctgcctga agaaccagaa aaagcgatcg cagaaggggc tgcttccggt 3046441 attccgctat taattggaac aacccgtgat gaaggatatt tatttttcac cccggattca 3046501 gacgttcatt ctcaggaaac gcttgatgca gcgctcgagt atttactagg gaagccgctg 3046561 gcagagaaag ttgccgattt gtatccgcgt tctctggaaa gccaaattca tatgatgact 3046621 gatttattat tttggcgccc tgccgtcgcc tatgcatccg cacagtctca ttacgcccct 3046681 gtctggatgt acaggttcga ttggcacccg aagaagccgc cgtacaataa agcgtttcac 3046741 gcattagagc ttccttttgt ctttggaaat ctggacggat tggaacgaat ggcaaaagcg 3046801 gagattacgg atgaggtgaa acagctttct cacacgatac aatcagcgtg gatcacgttc 3046861 gccaaaacag gaaacccaag caccgaagct gtgaattggc ctgcgtatca tgaagaaacg 3046921 agagagacgc tgattttaga ctcagagatt acgatcgaaa acgatcccga atctgaaaaa 3046981 aggcagaagc tattcccttc aaaaggagaa taaatatggg gaaaacagga tacattggtg 3047041 ctgccattgt tgtggcagct tgtatcatta ttttgtcggc cgtggtatgt ttacgggaca 3047101 cagtctatta ccagcctatg cgctggactg gcatcatact gtttttcgcg ggaattgtga 3047161 tggttcccgc atactcagca aaaagaaaac ccggaaaaga gaagtaattc tcttttccgg 3047221 gtttttatgt ttattataat cttcccgcgc gaatatcgtc tgtcattccc tcataaggag 3047281 ccttcgaaat cacttcttcg ttgtcgactc cttcattttt cagaaatgta atttccgcaa 3047341 attcaggtac aacgtatttt ggatacgttt catatttttc gcgggattct ttcatcaaat 3047401 caatgtggtc attttggtag caaaccgtaa tttcaggatg ttcatgcacc catttcggga 3047461 agaaaataat gccatgcatg cgtttttcat ttggcataaa gtttaatgaa acatccgtgc 3047521 cagtcggctc tgtccaagac actttatata cgccttctgt cagtttgaca atattcactt 3047581 cctgatctcg aacccagcgt ccggcaacca ttccgctatg aattctataa tcaattgtat 3047641 ggtcgttttt aatataaatc tcgtattccc atccgttttc atacgtataa atcatgtggc 3047701 ttccgataaa gttttccatc ttacacactc tccttagtct tttactgtac ttcataaatg 3047761 tctagtagaa cgtaatcagg ggttctttct gcggaaccga taaacaagcg gtcatggagc 3047821 cattgataga cttcactgcc tgtttcaaac gtcggtaccg tacgaaaata aacatgctcc 3047881 ggttcaataa tttccccggc tgccgcttgt tttcgaaacg gcttgctgac ttgccgtatt 3047941 ccattgtttt caatgtaaat cagttcatga tctgctgttt caatcacata cctggcagat 3048001 aaatctgttc tgccgttagc gcgaatcatt tgtgaatcgg caccgcccgg caaaatacgt 3048061 ccctttactt ccccggttat tgttcccgaa cgaatcggaa tgaatcatct cagtcccagg 3048121 cttgtctcac caatcgtgat aggcggatca accttgattt ctaaagaggc gaatggtttt 3048181 aaaaccggct tcttcacgag aaccacctca ccttcagaaa aaatcatgta actatttaca 3048241 tgttcacttt aacaccattg cagttaactg tcaaacaata ggaacataaa aaaacaagga 3048301 ctgtttgaag acagtccttg tctgaagcta gctttgataa gcaagatatg tgctgacagt 3048361 gcttttggca agacaggcag aggaatctat aatcggaatc tcactttgaa tatgatctaa 3048421 caccgcattt aaatccgtgc aggctgaaat gatgatgtct gcatgctgac tgatttcttc 3048481 atatagcgtc tgccacaatg cttgtgtatg ctgcatatga tttggctgtt tgattgcggc 3048541 gataagctgg ttcacagcct gctgccaatg gtccttgtga ataacttctt gtccatttcc 3048601 cttcagaact ttttggtaga tggcggattg gatggttggc tctgttccta aaaccaccgc 3048661 tttttttgcg ggatgcggaa tctcttttat cgtttcctca acaatatgca acataggaac 3048721 tgacaatgcc tgctgaatct cttcatagta gacatgcgcc gtattacaag gcagcgcaat 3048781 gaaatccacg cctgttttct cgagctttac cgctccgtcg ataatcgctt ttttcatctc 3048841 gtcatggtca attggacgat ctgcatagaa gggcgtcggg catgaataga tcatcatgtg 3048901 cggatagtca atatcgtttg aagccccata cagcttctga cagtaatcaa tcaccttatc 3048961 aataaacggc gaggtcgatt tcggccccat tccggctaat attccgatca tcaaattcat 3049021 tcctttctac ttcgtacgga ccgcttcttc ctctgagcca tcctcataga ggataaagct 3049081 tttcgcagca tcctcaccta atgtaaactc gacttcaaca gacaatgctc gcagaaagaa 3049141 acgggtttcc gaggaaggaa ataactccag tctcagctgt ccggcgatct ccaaataaag 3049201 ccgttcattc tcggttgtca cctgtgcagc cgtcccatcc tgcaacaggt agctgccaac 3049261 atagcggctg tatatcgccg tatcaattgc ttttttcttt ttatcagcag gacgttccgg 3049321 gacatcatat ggctggccaa atagaatatg ttccgccgcc ttcagaatcg cttgttcata 3049381 ttcagtatcc tcttccttat tactcaaata gatcagcgtt ttacgatgat cgatatatcg 3049441 gatcatcatc gtcgaatagc cgggccatcc tccgctgtgg ctgacaatcc gccctttttc 3049501 aggactgttt tgcagcaccc agccaaagcc ataatcaatt gtttctccat tgttgaggcg 3049561 cactggagaa aacgcagatt ccttagaagc cttgctgatg aaatcgtcct gatataaagc 3049621 ctgatcaaat cgaaacaaat cgcttgtgac agagttaacc gtcccatctc cctgtatgcc 3049681 atcgagatac acaacatagt tcgtttcctc cagctcatca gggaggacgt atgtttcgga 3049741 atgtacatca tacacatatc catatgcata atgatcaatt cgctcaggcg aaagcctcct 3049801 gttatacact cttgtttcat tcatgcctgc cggtaaaaaa atacttgttt ttataaaatc 3049861 cgcatagctc atgccagatg ctttttcaat gataaccgcc agcagcacat accccgtatt 3049921 gctgtacatc cagccttcat tcggttcaaa ataaccagat agcccctcat tcatcagcat 3049981 atcgacaata tcctgattca ccgcaatctt gtgtgaatcc caattggcaa aaaaccatcc 3050041 catataatca ggaagccctg acgtatggtt caataaatgc cgaatcgtta cgccctgata 3050101 cggaaaaccg ggcagccagc gatccacttt atcctcatag ccaagaatcc ccttctcctc 3050161 cagcaagatg attcccaatg ctgtaaaagg ctttgacaaa gacgctaact caaacaaaga 3050221 gttggttttc aacgggcgtt tttccgtcat ttccgcatag ccaaaagagt ggtgatataa 3050281 aatatcgcca ccctccgcag ccagaaccgt cccgttaaac tgatgttttt cgcctaatgt 3050341 ctcaaataac gtctgaagat gctttctttt attctgcttc attcctccac ctcccatatc 3050401 tctgtacgtt actaacctac taacgtttca aatattttga aaaatccttc agttagagat 3050461 cctttttaac ccatcacata tacctgccgt tcactattat ttagtgaaat gagatattat 3050521 gatattttct gaattgtgat taaaaaggca actttatgcc catgcaacag aaactataaa 3050581 aaatacagag aatgaaaaga aacagataga ttttttagtt ctttaggccc gtagtctgca 3050641 aatcctttta tgattttcta tcaaacaaaa gaggaaaata gaccagttgc aatccaaacg 3050701 agagtctaat agaatgaggt cgaaaagtaa atcgcgcggg tttgttactg ataaagcagg 3050761 caagacctaa aatgtgtaaa gggcaaagtg tatactttgg cgtcacccct tacatatttt 3050821 aggtcttttt ttattgtgcg taactaactt gccatcttca aacaggaggg ctggaagaag 3050881 cagaccgcta acacagtaca taaaaaagga gacatgaacg atgaacatca aaaagtttgc 3050941 aaaacaagca acagtattaa cctttactac cgcactgctg gcaggaggcg caactcaagc 3051001 gtttgcgaaa gaaacgaacc aaaagccata taaggaaaca tacggcattt cccatattac 3051061 acgccatgat atgctgcaaa tccctgaaca gcaaaaaaat gaaaaatatc aagttcctga 3051121 attcgattcg tccacaatta aaaatatctc ttctgcaaaa ggcctggacg tttgggacag 3051181 ctggccatta caaaacgctg acggcactgt cgcaaactat cacggctacc acatcgtctt 3051241 tgcattagcc ggagatccta aaaatgcgga tgacacatcg atttacatgt tctatcaaaa 3051301 agtcggcgaa acttctattg acagctggaa aaacgctggc cgcgtcttta aagacagcga 3051361 caaattcgat gcaaatgatt ctatcctaaa agaccaaaca caagaatggt caggttcagc 3051421 cacatttaca tctgacggaa aaatccgttt attctacact gatttctccg gtaaacatta 3051481 cggcaaacaa acactgacaa ctgcacaagt taacgtatca gcatcagaca gctctttgaa 3051541 catcaacggt gtagaggatt ataaatcaat ctttgacggt gacggaaaaa cgtatcaaaa 3051601 tgtacagcag ttcatcgatg aaggcaacta cagctcaggc gacaaccata cgctgagaga 3051661 tcctcactac gtagaagata aaggccacaa atacttagta tttgaagcaa acactggaac 3051721 tgaagatggc taccaaggcg aagaatcttt atttaacaaa gcatactatg gcaaaagcac 3051781 atcattcttc cgtcaagaaa gtcaaaaact tctgcaaagc gataaaaaac gcacggctga 3051841 gttagcaaac ggcgctctcg gtatgattga gctaaacgat gattacacac tgaaaaaagt 3051901 gatgaaaccg ctgattgcat ctaacacagt aacagatgaa attgaacgcg cgaacgtctt 3051961 taaaatgaac ggcaaatggt acctgttcac tgactcccgc ggatcaaaaa tgacgattga 3052021 cggcattacg tctaacgata tttacatgct tggttatgtt tctaattctt taactggccc 3052081 atacaagccg ctgaacaaaa ctggccttgt gttaaaaatg gatcttgatc ctaacgatgt 3052141 aacctttact tactcacact tcgctgtacc tcaagcgaaa ggaaacaatg tcgtgattac 3052201 aagctatatg acaaacagag gattctacgc agacaaacaa tcaacgtttg cgccaagctt 3052261 cctgctgaac atcaaaggca agaaaacatc tgttgtcaaa gacagcatcc ttgaacaagg 3052321 acaattaaca gttaacaaat aaaaacgcaa aagaaaatgc cgatatccta ttggcatttt 3052381 cttttatttc ttatcaacat aaaggtgaat cccatatgaa ctatataaaa gcaggcaaat 3052441 ggctaaccgt attcctaacc tttttaggaa tattgctgtt tatcgactta tttccaaaag 3052501 aagaacatga ccaaaaaaca aaatcaaaac agaagccgga ctaccgggcg gcatatcatt 3052561 ttacgacgcc ggataaatgg aaaaatgacc ctcaaaaacc gatctatttt gatggcaagt 3052621 atcattattt ctatctatat aaccgggatt acccaaaagg caacggcaca gaatggcgcc 3052681 atgccgtctc agaggatttg gtgcactgga ccgatgaagg cgtggcgatt ccgaaatata 3052741 caaacccgga cggtgatatt tggaccggtt ccgtcgtggt ggataaagag aacacagccg 3052801 gcttcgggaa aaatgcgctt gtcgcgattg tgacacagcc ctcagccaaa gacaaaaaac 3052861 aggaacaata tttgtggtac agcacagata agggaaaatc attcaaattc tacagtggca 3052921 accccgttat gcctaatccg ggcacagacg atttcagaga tccgaaagtc atatgggatg 3052981 accaagataa caaatgggtc atggtcatgg ctgaaggatc aaaaatcggc ttttatgaat 3053041 ccgataatct taaggactgg cattacacaa gcggattctt cccagaacag gcgggaatgg 3053101 tggaatgtcc cgacctctac atgatgcggg caagcgacgg aacgaataag tgggttctcg 3053161 gtgccagcgc gaatggcaaa ccgtggggca aaccaaatac gtacgcctac tggaccggaa 3053221 gcttcgacgg aaaagaattc aaagcggatc agactgaagc ccaatggctt gactatggct 3053281 tcgactggta tggcggtgtg acgttcgaag acagcaaaag cacagatcca ttagaaaagc 3053341 ggtatgcgct tgcctggatg aacaattggg attatgccaa caacaccccg acaatgaaga 3053401 acggctttaa cggcacagat tctgtcatac gcgaactccg gctgaaggag caggatggaa 3053461 catacagcct cgtctcacag ccgattgaag ctttggagca gctgactgtt tcaactgacg 3053521 aaatagagga tcaggatgtg aacggatcaa aaacattgtc gataacaggt gatacgtacc 3053581 agcttgatac ggatctttct tggtcagagc taaagaatgc aggcgtcagg ctcagagaat 3053641 cagaagacca aaaacgccat attgatgtcg gcattttcgc tgaaggcggc tatgcttatg 3053701 tcaatagagc agccacaaat cagcctgaca aaagcaatac ctatgtcgaa agcaaagctc 3053761 cttatgatgt aaacaaacgt aaggtgcatt tgaaaatact tgtcgataaa acaacgatag 3053821 aagtatttgt tggcgacggg aaaaccgttt tttcaaatga agtcttccca aagcctgaag 3053881 ataaaggaat taccctttat tctgacggcg gcacagcctc cttcaaaaat ataacagtga 3053941 aacactttga ttcgattcat gaataaaaac aggggcggcg caggctgccc ctgttttttt 3054001 attaggagcg gtattctctg ttacatattg ggcattgtaa ggaatataag gctggtttca 3054061 aaggaggaag cgaatgtcta aacaaggaaa ttttcaaaaa tcaatgtcgc tgtttgatct 3054121 gattttgatt gggatgggag ccatctttgg atcagcgtgg ctgttcgctg tcagtaatgt 3054181 cgcttcaaaa gcagggccct ccggcgcttt ttcctggatc ctcggaggag ccattatttt 3054241 gttaatcggg cttgtatatg cggagctcgg agccgctctg ccccgtaccg gaggcatcat 3054301 tcgatacccc gtttattcac atggccacct tgtcggctac ttaatttcgt ttgtcacgat 3054361 tgtcgcttat acaagcttga tttcaattga agtgacagct gtgcgccagt atgtggccta 3054421 ttggtttccc ggcctgacca ttaaagggtc tgattcgcct accatttccg gctggatctt 3054481 gcagtttgcc ctattatgct tgtttttcct gctgaattat tggagcgtca aaaccttcgc 3054541 taaggcgaat ttcatcatat cgatttttaa atatattgtg ccgattacca tcattattgt 3054601 gctgatcttt cattttcagc cggagaattt atccgttcaa ggatttgcac cgtttggatt 3054661 tacaggtatt caggctgcca tctcgacagg cggcgtcatg tttgcgtatc tcggcctgca 3054721 tccgattgta tctgtagcag gtgaagtcca aaatccaaaa cgcaatatcc cgatcgcttt 3054781 aatcatttgc atcatcgttt caaccatcat ttatactgtt ttgcaggtca cctttattgg 3054841 tgcaatcccg acagaaacac tgaaacatgg ctggccggca attggccggg agttctcatt 3054901 gccgtttaag gatattgcgg tcatgctcgg gttaggctgg cttgcaacgc ttgtcatttt 3054961 agacgccatt ctgtctcccg gaggaaacgg gaatatcttt atgaatacga catcccgcct 3055021 tgtttacgcc tgggcgcgta acggcacatt atttggcata ttctcaaagg tcaataaaga 3055081 tacggggaca ccccgcgctt cgctttggct ttcgtttgcc ctgtccattt tctggacact 3055141 tccctttcct tcgtggaacg cgctcgtcaa tgtctgttca gtcgcgctca ttctttcata 3055201 tgcgattgca cccatttctt cagctgcgct gagggtcaac gcgaaggact taaacaggcc 3055261 gttttattta aagggaatga gcattatcgg gccgctttcc tttatattta cagcgtttat 3055321 cgtgtactgg tcaggatgga aaacagtctc ctggctgctc ggttcacaac tcgtgatgtt 3055381 tttgatctat ctctgtttca gcaaatatac gcctaaagaa gatgtcagcc ttgctcagca 3055441 gctgaaatca gcctggtggc ttatcgggtt ttatattatg atgctgatct tttcctacat 3055501 cggttctttc ggacatggtt tagggattat cagcaatccc gtcgacctca ttttagtcgc 3055561 gatcggctca cttgcgattt attactgggc aaagtatacc gggctcccaa aagccgccat 3055621 tgattatgat aaataaagaa gcaagaggtt ttcttgcttc tttattcttt acaaacaaac 3055681 atacacgcga taaaatgaat gagagtcagt cattactgga ggtgttcctc atgccaaaac 3055741 aaacatcggg taaatacgaa aaaatattgc aggcggccat agaagtcatt tctgaaaaag 3055801 gcctcgacaa agcttctatt tctgatattg tcaaaaaggc cggcactgcc caaggaacat 3055861 tctatttgta tttttcatct aaaaatgccc tcataccggc cattgcagaa aatctcctca 3055921 cccatacact tgatcaaatc aaaggtaggc tccatgggga cgaggatttt tggaccgttt 3055981 tagatatatt aattgatgag acatttctca ttacagaacg ccataaggat attattgtcc 3056041 tctgttattc cgggcttgcg atcgaccact ccatggaaaa atgggagacg atctatcagc 3056101 cttattattc ctggcttgaa aaaatcatca acaaggccat tgcaaaccat gaggtaacgg 3056161 aaggaatcaa ttcaaaatgg acggccagaa cgattatcaa cttggtcgag aatactgcgg 3056221 aacgattcta tatcggattt gaacaagatg aaaatgttga agtgtataaa aaggaaattt 3056281 tcactttctt aaaacggagc ttaggtactg cttaaaaaat gactgggtaa caccgctcat 3056341 tttttaatgc cctaaaaatg actgacgttc attcataaaa tagagaggtg tttcatttga 3056401 attgggttct tgtttttatt gcagggcttt tagaggttgt ttgggcctct tccctcaaac 3056461 atgccgattc gcttttggat tggatcatca tttttatctt aatcgcggtc agctttatcc 3056521 tgttgatccg ctcttatcaa aaaatcccga tggccgcggc gtacactgtg tttgtgggaa 3056581 tcggaaccgt cggaacatat ctgactggaa ttgttctggg cgaatccttc tcagcagccc 3056641 aaatgttctt tttagcttta ttgctggctg gcattttagg aatgaaatta tttacgaaag 3056701 aaagcaaatc tcagccggga ggtgaaaaat aatggcatgg tttttattag tgattgccgg 3056761 catagaagaa attatagctg ccattgccat gaaatatata gacggaacaa gaaaaaaatg 3056821 gccgatcatt gtgatgactg ttggattcgg cttatccttt tactgcctgt cccaagcgat 3056881 gatcgtcctg cctgccggag tcgcatatgc cgtctggact ggcattggaa gcattggtgt 3056941 ttcggcggtc gggctcatct ggtttaagga gcggtttcag ctttcacagg tgatttcact 3057001 ttgccttatc ctagccggcg tcatcggcct gcgtcttacg tcatcttcat aaaatcaagg 3057061 catatacagc tgtatatgcc tttgccatta agcttcgtga tgtttttgaa gatgaagcgg 3057121 cggcgggatg agccagcctt tgttttttag cagccttaag tattttgcgc cggttgccgc 3057181 tttcgacata tgaaattgcc caaacatcat ggcaatatcc tcacgaatcg attgccccat 3057241 cattttgctg catgtcacaa gacctgcagc attttctgct gccgcggaag ccgccacatc 3057301 cggatcgaga aaccgtgcac caggcggaat atcgttaaga tctgctgtcg gcggttcagg 3057361 agaagccggc ggcagcgcca ccccgttttc tttcaggatc gtgctgacct gtttgatttc 3057421 atcttggcat ttctcaatag actcacgaag cagcttcttc aggtcgtcat caccgacatg 3057481 attcaatagc atttggtaat tgccgaccat tttattgccc gccatcacat aactccacaa 3057541 gccgaatacc tcaccgtaat gcatcggttc atcctgcgga tttccgctta aaatacccat 3057601 gctcattctc ctcccatatt caatattgca catttcataa cgtgcccaag cggaggaaca 3057661 tttatgtttc agcggaaaag atttatgaaa tgaaacaaaa caaaaaagac aagagtggca 3057721 agttgccaaa ccattgtctt tcctgttgtt tgattggacg cactgaaggg attcgcaccc 3057781 cgacagacaa gataccggaa accattcaag tgctttttag tatgagtcat tgattctgtc 3057841 tttaataaac tttaacgaga tggcgggatg ctttgcggaa aacgaaatac attttcgggg 3057901 tcatatttcg cctttatttc tcgaagccgc gcaaagtttg cgccataata ttcttttccg 3057961 aagttttcaa tgttttgatc tggaacatta acatatgaac ctgctacata tggttgcatc 3058021 agctgacgca ctctttcaac tgatgcaaga tttgaatctt cttgtgattt atttttccaa 3058081 ctagccgtcc attccgtata aaataatgga tggcgccaaa aaaaggcagt ttcgtcttta 3058141 gggactctgc ttatagcacc accccaattg ataaaaaaga aattggcttc tgttccagta 3058201 gcatcttcca aaaattttct catgattgaa atgggttcgt cagaccaaaa atcatgaccc 3058261 catgccgagg agaatttaac actctgatca tttctgccag ggatgggttc gtcagggtct 3058321 aagaaatcta tagcatctgg atagtataat gttttgatat ctgcttctgt tggagttccc 3058381 gcatgtaata aaggttttaa taatcgaatc aattcagttt tcgaaccgag gaaaattcct 3058441 tctgcatgac acaaaccatt tattttgctg taaatttcaa ggtagcatcc taatcgttca 3058501 tctacaaacg gagcccattt ctgccaagct ttaaataccg tttctaattg ttcccacggc 3058561 cagataatat tgaagacggt tgcagtttta ggggcacgat gaactttgaa tgtatattgg 3058621 gtattatatc caaagttacc tcctcctccg cctctagaag cccatagcaa atcctcattg 3058681 tgagattgat ctgcgtgaat aatccttcct tttgcatcta ccgttttcag cgcgagaagg 3058741 ttatcactta taaggccaat cgatcgtgag agtacaccaa atccgccgcc catcgtaatt 3058801 cccccgattc caactgttgg gctatctcca aacggagcca taaaaccgtc tcgagctaat 3058861 ccctttacaa gcgggccaac gggaatacca gtttgaacgg ttgcaatagc gttttcttca 3058921 tctaagaaaa ctttattcat gtcactcaca tcaataacaa ttcctccact tactactgaa 3058981 aggttcttat ctaaagcatg gcgaccgctt ctgacacgta agggcacttt attctcacga 3059041 gcccatttaa tggcattact tacatcgtat gaattttgcg caaaaacaaa gacaagagga 3059101 tagacatcca cataagggtt ccaattctta atagcctctg tatagccggg gtctcctttg 3059161 aagattacac gccctgtcaa ctgtgttgat cccatatatt atttcactcc caaagaaatt 3059221 cgattcagat actaaaatat gcaggagctg gataatcgca tagacaaatg atctacgaac 3059281 tataaatata atacgctaag gcctttttcg tcggtgaggt ctgctgagaa acatttttca 3059341 aacaattttg agcaaacttc ctgtccaatc ctccaacaag cgttttttct tatcgttttt 3059401 aggagcagtg tccagttttt ttcggagtga atattcgttt aggccaaaag aaaagagaga 3059461 tgaagaagtg tttagtacca gaggtataca tccatacaac agactctaga tcatcatata 3059521 ctgaatgtat gtagaaagga gacatcagct ttggcaaaat atcggattat gacctttgac 3059581 ggcggcggta ccttaggtgc tttaagttta caactattaa acagattggc taggcaaaac 3059641 ccgaagttaa ttagtcgaac ccatgtattt tcgggaaatt caatcggttc atttactgcc 3059701 cttgcattag caagcggaag atctccgagg gaaacacttc agtattttga ggatgaaatc 3059761 ctacccgcat tcagcatttc ccggccaggc ggacctgttt tcaaccaaca attaccctat 3059821 tccggtttta ttaaagcggt aagaaatttt ttcccagcag atcttcaact tatagattta 3059881 agaaaacgaa ttgttgtccc atcattcaaa ttatactctc aaaaactgga ccgttggact 3059941 cctgtcttat ttcacaattt tcccggctct ccctatttaa atgaaaaagt gagtgatgtc 3060001 atactgcgga gcagcggtgc tcccgcgacg caacgcgcct atcaaaacta tgtggacgga 3060061 tatgtagtag caacgaatcc cagtacagcc agtatcgcgt ttgcagttgg taaagccaac 3060121 gtgccattgg atcaaattgc ggtattgtcc atcggaacag gtgaagcccc gactcggtta 3060181 agaagagata cgaggggatg gggaatggta agtgcagata acatacgtcc cgaaaatctg 3060241 aagaaccttc ctccaaattg gggagtcctt ttggacaggt cgcctaatga acctttactg 3060301 ccatttcttc agatgattgc tggcggtaat gggtactatg aatccatggt cagtgcgaat 3060361 cttctgggag atcgtttttt ccggttagat ccgcggattc cgaacttctc caaaacggac 3060421 cctgccgtcg ttcccgctgt cattgaaatt gcgaacaaaa caaacttaca gcctgcgaat 3060481 caatttatag agaagaactg ggggagcaaa taattattta ttttaaatca attctcgctt 3060541 atacaatttt gtccgagaga agattctcaa aataaataca ggcaatgggt agaaccggat 3060601 ttttttaaag gtttgttaat cacaagctaa taagatgaat gaaaaaatca attcatactt 3060661 cttcttttga aagtgagggt tcaaactaaa gaatgtaatt gaaatgttac tctaaggtat 3060721 gcaattccct ttttcacaca aaaaaagaca agagcggcaa atcgccaaac ccttgtcttt 3060781 cctgttgttc tattggacgc gctcggaggg attcgaaccc ccgacagacg tggtaccgga 3060841 aaccaccgct ctatccaact gagctacgag cgcatataga ctgcgttatg agaacgtcag 3060901 cacaactaat tatacgataa ttcctttcaa ataacaaccc tctatttcga gaggccgttt 3060961 tttaaataga caaagcatct taattggcaa tctgacatac gatggtttga acccctgtat 3061021 ttttggggaa aatgggaaaa agagacgact ttgcatatca ggccagcttt ttgtttgacc 3061081 tttattgacc aaaaatgtat catgtaacta catacttacc taaaaggtga aggaggagca 3061141 ttatgaattt aatacctaca gtcattgaac aaacgaaccg cggggaaaga gcgtatgaca 3061201 tttattctcg tctattaaag gatcgtatca tcatgcttgg atctgcgatt gatgacaacg 3061261 ttgcgaactc catcgtgtca cagcttttat tcttagcagc agaagaccct gaaaaagaaa 3061321 tttctcttta catcaacagc ccgggcggct ctattacagc cggtatggcg atctatgata 3061381 ccatgcagtt tattaagccg aaggtatcta caatttgtat cggtatggct gcgtcaatgg 3061441 gcgcgttcct gcttgcagcc ggcgaaaaag gcaaacgcta tgcgcttcca aacagtgaag 3061501 tcatgattca ccagcctctt ggcggtgcgc aaggtcaagc gacagaaatt gaaattgctg 3061561 cgaaacgcat tctcttgctt cgcgacaaat taaacaaagt cctagctgaa cgtactggcc 3061621 agccgcttga agtgatcgaa cgcgacacag accgtgataa cttcaagtct gctgaagaag 3061681 cgcttgaata cggcctgatt gacaaaattt tgactcacac agaagacaaa aagtaataac 3061741 acaacctgca agagctgcgt ctcttgcagg tttttttcat ttcaaggaat tgactccctt 3061801 attctatact gctcccattc ctcatgtaac agctcaagcg tcaaatcact cgtctgcctc 3061861 acaaccagat cagcaccaag catcggctgt ccttgaccga caccaaccgc aaacatcccc 3061921 gcagatttga ttgcagaaat gcctgcttct gcgtcttcta ttgccgcgca atcagcaggg 3061981 gaaacatcga gcatcgctgc agctgttaaa aagatgtcag gatcaggctt ccccttcgca 3062041 agagtcgtcg gatcaacaat ggcatgaaaa tcatcgataa ttgccaagcg tcttaaaatc 3062101 ttaggagcat tgcgacttga agatgctaac ccgattttta tattttcgtt tttcaattga 3062161 catagaagcc tgccaatccc cggtaaaaga tcttccggcg tcaatttgct gatcagcatt 3062221 tgataatcgc gatttttccg atgcataagc tcttgtttct ccgcatttgt atactttgtt 3062281 tccgccccgc caaagatcaa tatgctttca agtgactctt ctctgctgat tccttttagc 3062341 ctttcattca tgtctctgtc aaaagggata tcgatttgtt ctgcgatgtg cttccaagcg 3062401 agaaaatgat attcagcagt atctgttatc actccgtcta aatcaaaaat gaccgctttc 3062461 atatactaat gcccatcaca gcttcataag gtttgaggct aatactcttt aagtcagccc 3062521 gctcctgcgg atagtttgaa attagcactt tccaacgctc atgaatcagt tctggaggcg 3062581 cttcgaacag agccttttct tccgataaat tcacaacgac aagaagcttt tcccctcgat 3062641 attctcgaag gtaagaaaag acctgcggat cattctcctg caacagctga taatcgccat 3062701 atatcataat cttatattgc tttcgtaatt gaatgagctt ctgatagtaa aagaaaatcg 3062761 aatcttgatc ttccaaagac tctttcacat tgatatcttg atagcgggaa tttaccggta 3062821 tccacgggtc tccggctgtg aatcccgcat gttttccggc atcccactgc atcggtgttc 3062881 tcgcatgatc ccttcctttt atcatcacgg ctttgacaaa ctctttttct gacatcgttt 3062941 tgttttcgac gactagttca cgatatgcat tctttatttc aagatcatca tacatctcca 3063001 gcggcatatc gctgttgacc atgccgattt cttctccctg gtaaataaac ggcgttcctt 3063061 tcatgccgtg cagaaccgtt gcaaatgcct tcgcacattc cttacgcagt ttcctgtcat 3063121 tgccccagcg ggaaataacc ctcggctggt catggttctc aaaataaagg gtattccagc 3063181 cgacattcat taacccggtc tgccaccttg tcatcgtctt ttttaaagca atcaaatcaa 3063241 acggcttgat ctgccatttc ccatttggcg agttttgttc tttatcaata tccatatgtt 3063301 caaatgtaaa gatcatattc agctcttgcc tgcttgcatc tgtgtacttt ttcgcctctt 3063361 caatatcaga gccgtttgcc tctccgactg tcatgcagtc gtaatgagaa agcacttccc 3063421 tgttcatctc ttgaataaac tcatgaagac gtgggccgtt agagtgataa cggccgacaa 3063481 tatagctgcg gctgtgatcc gtttcgtagt ccggaaaatc ggtgtattta gaaatagagc 3063541 caatcacatc catccgccag ccgtcaacgc ctctatccat ccagaatctc attacatcat 3063601 aaacttcccg gcgaacggct tcgttttccc aatttaaatc aggctgtttt ttcgaaaagt 3063661 agtgcaaata atactgccct gttccttcat cgtatgtcca cgctgagcct gaaaagatcg 3063721 atccccaatt attcggctct gagccgtccg gtttaggatc tttccaaaga taataatccc 3063781 ggtaaggatt gtccttcgac ttgcggcttt cagcaaacca agcatgctca tctgatgtgt 3063841 ggttcacgac caaatccatg acgattttca ttccgcgttt atggacttca tcaatcagct 3063901 gaaacatatc ttcatttgtc ccaaactttt cgtacatgtt tttgtaatcg ctgatatcat 3063961 atccgttgtc atcctgcggg gaatcaaata ccggggagag ccagatgaca tccgccccga 3064021 ggtttttgat gtaatccagc ttttgaatca caccttgcaa atctccgaat ccatctccat 3064081 tggcatcata aaaactgcgc gggtaaattt gataaacgac agcttctttc caccattcac 3064141 tcattaggcg ttctcctttc acatcgtccc tgtaggacaa ccggttcctc ataaacgttc 3064201 atgtgcagcg gctcgccttt tacaagctca aaaataacgc gcttttcgtc aaccgtcaca 3064261 ttgattaatc gatttcgata attgatgttg aatgaatatt cgtcccattc tttcggcaaa 3064321 aacggagcaa atgacagcgt ctcattcgcg gtgcgcatgc ctgcaaagcc atgaacgatt 3064381 gccagccagc tacccgtcat tgaagtaata tgcaagcctt cttccgtatc atgattgtaa 3064441 ttatcaagat caagccttgc tgtgcgctta tataattcga gcgctttctt ttccagcttg 3064501 agttcggctg cgagaatcgc atggacagag ggcgataggc ttgattcatg aacagtcatc 3064561 ggctcataaa attcaaaatt tcgccgtttt tcttccattg taaaacggtc attaaaaaga 3064621 taaatgcctt ggagaacatc tgcctgctta ataaaattgg agcggagaat cttgtcccat 3064681 gaccaattct ggtaaagagg ccgttccgct ggatctaatt cgtcaactgt ttgcaggtct 3064741 ttgtccaaga acgtgtcatg ctgaacgaaa atttgcagtt cttcactaaa tggatagtac 3064801 atgtgctgga tgatttctct ccagacttcc aattctactt cctgcacatc cagatggcgg 3064861 cgtttctccg ctgagatact ttcgagactt tgtagagtat actccaacgt ccaagccgca 3064921 atgacattcg tataccaatt gttgttaacg ttgttttcgt attcattcgg ccctgtgacg 3064981 ccatggatca tatacttatt ttttcgtttc gagaagtgaa cacggtcggc ccaaaatctg 3065041 ctgactgcca caagtacgtc tatcccgtat tcttccatat agttacggtc gcctgtataa 3065101 ttgatataat tgtagatcgc ataacagatc gcgccattgc ggtgaatttc ttcaaaggtg 3065161 atttcccatt cgttgtggca ttcatcacct gtgaacgtca ccatcggata aagtgccccc 3065221 ttcatcccca attttgcagc gtttcgtttg gcagcctcca actgatgata gcgatacaaa 3065281 agcaggtttt tcgtcacctc cggctcggct gtcgccaaat acatcggaac ggcgtacgcc 3065341 tcagtatccc aatatgcggc acctccatat ttctcgccag taaatccttt cggcccgata 3065401 ttcaaacggg catcgccccc gtaatatgtc gagaataact gaaagatatt gtagcggatt 3065461 ccttgttgaa gctcctcatc tcctttaatc tcaatgtccg cttttgccca tctttccttc 3065521 catcgatcag tgtgcctccg ttttgcatct tcatagccgt tctctaccac atccgccaaa 3065581 agctccttgg ctttcgataa aagctcttcc tcccgaaaat cacgggaagt cgtgacaatc 3065641 acaaactttt tcaatgatgc cttcgtttga taactgtagc gattctcgac atacatttca 3065701 gtcgttttaa agctttcatg gacaaaaccc tccgtctcgt ttgccattgc ggctaatacc 3065761 gtgaagcgcg gtgttccaaa tggattttcg atcgtttttg ccgctaaatg gccgctgtga 3065821 gaatcagcac ctttcgcttc ctcctgccaa aactgttctt ggtagttaga atcttcattt 3065881 gccacatttc catccaggta aggaacaagc gtaatgacag catctcccgt caagcactcc 3065941 gcttcataat gaatcgcaca gagttctttt acagcaaggc taagaaaccg ctctgacctg 3066001 attctgacgg ttttatcttg aatgcggaca acagcgcttc gccgcagaat cccctctttc 3066061 atattgagtt ctacctcaaa taattcgatt gggttttgat ggagatcgat tttttcaccg 3066121 tcaacatata ggcctatgcc cataaagttc atcgcattga tcacttttcc gaaatattct 3066181 ggatacccgt ttttccacca gcctactcgc gttttgtcgg ggaaccacac gcctgcaata 3066241 tatgtgcctt ggtgactgtc gcctgaatag ccttcttcaa aattccctct gacccccata 3066301 tagccattgg caagagacgt caggctttcc agcagccgtg tatgctcctt attaaatgta 3066361 tttgttttga ttttccattc atcaatctca aataaccgct gatttatcat catttcctcc 3066421 cgaatgtaag tttccattat cacggcgggt tttggtcaaa tatctaaatg caaaagagat 3066481 catcaaagta acgccacacg aatggatcat caatacagta atcaaatcaa aatgaaccat 3066541 gccgatagca gctgccgcaa atgccggcag tgctgatgcg caaatcgcta tagaggccgc 3066601 ttccttgaat gatgcaatag agaccatgtt tgatattttt gtgatccaga ggccacctgc 3066661 aagaacaaac gttaacaaaa gctggatcat agaaaccacc gtatatgcca gcatcatgat 3066721 catcggctta tactgtgcca accacaatgt atcgatcaag acctctacat catggacgtt 3066781 tggtttctcg agcttaacgt ccattttcgc atagccaaca gaaaaccccg tttcgttttg 3066841 atcggtgatc accagttgat caggttgaaa tatgatggcg ttttcaaatc cagttacttt 3066901 caatcgccca ttttcaccgc ttgtctcata ttcatgcttc atatcgactg ccatcacatt 3066961 ctgcccatct tcaatcctct cagagctctt cccgcctgtt agttttccgt tcctgatttg 3067021 aaaaccctgc aattgatcag caaattgatc attaactcct tgaatcgctg acggcatgaa 3067081 agatgaaacg ctgaagcgat ccattttcac aaacgaaacc gctaacggcg ccattaagca 3067141 ggccgttaaa aacagaaaga gaaaagagag ctgcagccag ctgaaggtat tcccatagcg 3067201 gcaaacacct gatggggatg cagccgcctt caggcagcgg atgataaagc ttttattctc 3067261 cagattcttc attggcatta cccctttgtt ccgccggctg tcaaaccgga cacaaagttc 3067321 ttttggagaa aaaagaatag aacgcatatc ggcagtgcgg ctagtatggc accggctgca 3067381 aatagagcta ctttttgctg ctgcggatta gaaataaagg attgtaatcc tacagcgatg 3067441 gtcagccttt ccggtgagcg aagcagaaat ttcgtcagca aatagtcgcc aaacggtgcc 3067501 ataaacgccc aaagcgcttg taccgcgagc attggcttaa caagcggtag aacaattgaa 3067561 gcgaaaatcc tcagatgtcc cgctccgtca attcgcgcgg cttcatcaat ttctctcggc 3067621 acagtatcaa aataaccttt catcagccac gtgttcatcg gaattccgcc gccgatatag 3067681 atcgctgtta aaaaccagta ttgatcgagt gcgcctatta gcatcgccaa gacataaaaa 3067741 gcagtcagcg ccgccattgt cggcaccatt tgaatgatta aaaagaatat caggctcttt 3067801 tttctgcctg caaaccgata gcggctgtac gagtacccgg caagtgtcac aatcgtaacc 3067861 tgcaaaacca tgaccgatag cgcgatgaca agtgtattgc tgtaccaatt gagataaagc 3067921 gtttcgtcaa atagccgctt aaaatgatcc aatgtccaag aacccgaaaa atcgagctga 3067981 aaagccgccg aattccccac acggaaggct gatgatgccg taatcagcaa cggatatata 3068041 atgacaatac ttaaaagcgt caaaaataaa tacgtacaga ttttattaag cattctggca 3068101 gtgctcgcgt tcacctacat aacctcctca ttgccaaaag cattcgattt tttgaaagca 3068161 atcagtgaaa ttccaatgac aatgaaagaa attaacagtg tcacagccgc cgcaacggaa 3068221 tattggggtg atgtgcctgt tgtcagttta taaatccacg aaattaagat atcggtcgat 3068281 ccggccccgg ctcccgcact gcctggccct ccctcattaa ataaatagat gatcgagaaa 3068341 ttattgaaat taaacgtata ctgagtaatc atcacgggtg ctgtggcaaa taaaatcatc 3068401 gggaatgtaa tatgccgaaa acgctgaata aaagtggccc cgtcaatctt tgccgcttca 3068461 tacaattcac ctggaatcgc ctgaagcact cccgttacca tgacatatat atatggaaag 3068521 ccgagccacg tttgaatcat aatgagggct gtctttgtcc agaaaggatc ggtcttccac 3068581 gcgatcgcag gcagctcgac aaacggcagg tgattgaata atggtatcac ctgtgcattc 3068641 accgctccta tgctgtcgtt aaacatgttg gaaaaactca tgattgtaat aaacgccgga 3068701 acagcccatg gaaataagaa aatcattcga aatatccgct tgccttttat aaaatcctga 3068761 ttgacgaaaa gtgccgtcac aatacctaaa atgatttgca gcgttgttgc acagattgtc 3068821 cagataaccg tccagcccag tacattcaca aatgtttcac gataggagcc aaggaaaaaa 3068881 atatttaaga aatttttaaa cccgacccag tcaatcagac gattaggcgg aatatgataa 3068941 aaatcatagt ttgttaatgc aacaaacaga gtcaccaaaa ccggaaaaat aatcacaaac 3069001 accatcatga tatatgccgg cagtgtaaat agatacggaa aacctttatc gcccgcatga 3069061 cagatcatat ccttggctgt tgtattgact tccaaacccg ccgctttcat agcggcggtc 3069121 ttacgtgaat catgaatatt aaagatatag aacatgagga aaatcattgt cacgatcaat 3069181 tgcagcgtgc cttcaatcag cataaacagc gagtgatctt caccgggaac acttcccaat 3069241 gtcatcaatc cggttagcgc ctgtataccg aaaacgcata attcaaaagc aaacaagcct 3069301 gtgatggcaa gaaataagag cccctttgac aactgctgat tcgcaatctg cccaagtcct 3069361 ggaatgatcg ataaaagccc tgcctttcgt ttttgctttg taagtgtgtg atgtttattc 3069421 atttttccgc cctctattct tccggacgct atcccgccgt tttatttcac atacttttct 3069481 ttaatatttt cctttatgac gtttacagca tcattcgctg atgtttgtgt cgattttttt 3069541 cctgaagctg catcaaaaat taaactttcc gctcctgtcc atacttcagc catttccgga 3069601 atatttggag tcggcgttgc tgtttcatat tgtttaatca cagctgacgt cagttcattc 3069661 ttttgctcat cggctttctt ccttgcagcc gtgttggccg gaacttcgtt tgtatcctca 3069721 taaaaagcgt aagcattggc atcatttgca gcatactcaa gccatttttc agccagctcg 3069781 ggctcttttg tatatttcga ggcaacccag cccttcccgc cagcaaaagg ggcgtattct 3069841 tctccatttg gcaatgtcgg aatgggagcc gctccgtagt tcaatttagc ctctttatag 3069901 ttggcagctg accaaggacc gccaatgatc gcagccgctt tgccttctaa aaacatctgc 3069961 tgaataaagt cgtctgcgct tgaattgtct tgcattcctt tcggccaata tgtctcaaac 3070021 catttctccg catatttcac cgcttctaca gcccctttat tgttcaggcc gatgtccccg 3070081 gaatctgtgc cgttttttcc aaacacatat ccgccgtatc cagccaataa gccgtacgac 3070141 atataaaagt cagtccattt tgctaaaaat ccggttgatt ttcctttttc cgaagcaaac 3070201 gcgaatcgag gatcttccgt taacttttca aggtctttaa atgtttttgg cgctgttttt 3070261 aaaagatctt tgttgtaata caaaataagt gtctcaatga ctagcggcat tccgtacact 3070321 ttgccgtcaa ctgtcacctg ctgcatttct ttatcaccaa agctttttgt gttagatggc 3070381 ttaatatcaa gtaaatgtcc ttgttgtccc aaaccgccga tccggtcata tgcagcaagc 3070441 ataacatcag gcgcattacc cgccgggcca tcaagaggaa gcgcttctaa ctgttcgaac 3070501 atttgctttt caacaatttt tactgtgaca tcattttctt tttcgaactt tgtttttatg 3070561 ctttcaatgt attctttata cgtttcttcg acagacacag tcagcacctt tttgccatca 3070621 gagcttgctg gattttttga acttgagcag gcggcaaggc cgattgccag gaatgatgcc 3070681 gccaatatgg cgaacccctt ttttaaaaga accatctctt ttcctccttc tatttacgaa 3070741 actataacaa ttgtattgtc ctatagaaag cggttacaac aactttcgat ttgttaccga 3070801 taacagaatg ttatacaggg gcggcagcac tcaaaatcaa aaattctccc ggctgaacgg 3070861 caatgacatc gtgatgctgt agcggctgct ctgtccatgc atcacagatt ttcttattcc 3070921 tatcaatatt caactctcgt aaactgacgt gttgaaccac attcccttga ttaaagaaat 3070981 aaatcagtat tttttcatca agagtccgcg aaaagctaat gaaatcattt ttgtcgtcca 3071041 gcagattcca ctcaagatgt ccttcagtca ataaagtgtt ttcctgcttg cgtaaagcaa 3071101 ttaaccgttt cataaattgc agcatgtctt ggttttgctt ctctttttcc caaaccatac 3071161 atttccggca taatggatca ttttcgccgt tcagcccgat ttccgttccg taataaatgc 3071221 atggtgagcc tgtctgggca aacataaagg ccagcaacgc gcgtgctttc ttctcatcat 3071281 tgcggcatct ggtcaaaagg cgctttgtat catggctatc cagtaaatta aacatcacct 3071341 cattggcctg cttcattcca ttcatcaaat gtgcattgac acggtgagcc atacgtgaag 3071401 ctgagatcgt ctggtcagca aagtattcaa tcataggctc tgtaaaaggg taattcatcg 3071461 ccgcatgaaa ttcatcccct ctaagccagg gttcggcaga atgccagatc tcacctaaaa 3071521 tataaacatc aggcttttca gtagatacag cctgcctaaa tgtcttccaa aaaacgtgat 3071581 ccacttcatt tgcgacatcc aaacgccagc cgtcaatgtc aaattcgcga atccagtaca 3071641 aagcaatatc aagcaaatat ttctgcacct cgggattagc cgtgtttagc ttcggcatat 3071701 cagctgtaaa agcaaatctg tcataattgt cgtctgtgac gggaaaagag tgaatatgga 3071761 accagtcctt atagcgggat tgatctccgt ttttgacgac atcctgccat tgcggagacg 3071821 cgcttcctat atggttaaaa accgcatcaa gcataattct catcccccgc tgatgcagct 3071881 ggctgaccaa tgtacgaaaa agctcaggat ccccgaaatg cggatcaata gaaaagtaat 3071941 ccagcgtgtc gtatttatga ttagaaggcg cggaaaagat cggtgtcaga taaatgccgt 3072001 tcacccctaa atcctctaaa taatcaagct tgtcaacaat tccttgtaaa tcccctccaa 3072061 aaaaatcatt gacgtccggg tccttgctcc cccacggcaa tgcattcttc ggtgacaagt 3072121 cttctcttcc atttgcaaaa cgctccggaa aaatttgata ccaaaccgtt gacttgaccc 3072181 attcaggcgc ttgaaatgta tcagcctcgt gaacaaacgg aaatttaaag taataatgaa 3072241 tcgtttccag tgttttttcg ttataagggc atacacccga acttccgaaa aagatgtctt 3072301 catgatcgtc tgttacaaca aacgcatatt gtaaacgcct aaatggcggc accacttcag 3072361 caaaccaata gtcatgcatt tctgtagcag caattttcct catcggctgc tcgtttgccg 3072421 accatttgcc gtcgttgtac tcatagggat caccccaaat gaatcgaatg tgatctgcat 3072481 cacctttttt cgtccgaatc ttgatatgca cagtccgccc atcataagaa taagcatctg 3072541 tgctgaatgg ctggtgatga atcgctgcat attccatcat gtttccccct ttgatttccg 3072601 ttttattgaa gccggctcat agtttgaaag tatcatgatg aaattgtggg aacaatcctt 3072661 ttcaccctgt taccgataac agaataaggc gcttacagcg ttgattctcg tacaattaac 3072721 tctggttcaa aaaatagact tccttgtgca gcgccgtctt cattcatttt tttcagcaac 3072781 attttcgcac aggcttcccc catttcaaca acaggctgtc tgaccgtagt caagcgcggc 3072841 gaggagatgc gatcaagaaa cacaccgtca ttcccggtaa ccgcaacgtc ttctggaatt 3072901 cgctttccaa gggattgcgc cgcacgaatg acgccgagcg cgattcgatc agatgcgcag 3072961 acaaatgcgg cctgattgtc catggatttc agcagttctc ttgcaaggca ttcacttttc 3073021 ttagaactgt tgtcgatccg aaacatattc gattttttaa agcttttatt catcgcccgt 3073081 atatacccct gttctcttgc acgttcgaaa ggctcatcta aatcaatgcc aaaaaagaca 3073141 acttcccgct cccccagccc cataacatgg cgggttgcca taaaagtgcc tttctcgtta 3073201 ttcacatcga taaagtcata gcccatttca ttttgtccaa atacgacgag cggcttctca 3073261 aaagctttta ttacaccttc aaaatcgttc tttctcaagc cggtggcaat aatgccgtca 3073321 cattggccaa tattaagaga atttcttgtc acaagctgga gagcatagtg attgcgatcc 3073381 agctccctgc tgattcctgt cagcaggttc atgtaatatg gttctgtcgt atccatttcc 3073441 tcaagtatca atagtttcac aacctgtgtt ctgttttgca cgagcgctct cgccgcataa 3073501 ttagggatgt aattcagctc tttcatcgca gaatgaacaa gctttttcaa ttcatccgtc 3073561 accgtctcag ggtgattgat cactcgtgat accgtcattt tcgaaacatt tgcttttttc 3073621 gccacatctg acaatgttgc cattttcatc ccctccttat ctgtgcttat tatccaaact 3073681 agtgataaag tcctctatta ctgctaaata tacgatgcag gccaaagaga aataaaaaag 3073741 agatttccct taaggaaacc tcactttgtt aaaaacactc gatttttcat ggattcatac 3073801 gctaggtggc agactcattc tctccacttc catcagaaaa tctctttttt aaatttctgt 3073861 ccactttttt tctaaaatcg gataagaata attttgcatt tgctcaatta actcatccgg 3073921 ccgtgacgag ctgtgaatca gttttaggtg cgattcgtta gaaaaccctt cttgaatgct 3073981 gtatttcacc attttcatca ttggttcaaa atatccgttt acattgtaca gtccaattgg 3074041 cttttggtgg atgccgatct gtgcccagca cagcacttca aataattctt catatgtacc 3074101 gaagccgccc ggcatcgaga taaagccgtc cgccagctcg ctcattttag cctttcgttc 3074161 atgcatcccg tttacttcaa tcagctcagt cagattctga tggacaacct ccccgctgaa 3074221 caaaccgctc ggcatgaccc cgattgcagt tccgccgttt tccataatcg cgtcagcaat 3074281 cgtgcccatc aagcctacgc gggagccccc atagacaagg ccgattccct gctcagccat 3074341 atacacgcca agctctgccg cttttctttt atacgcttca tttcccccag ggtttgatcc 3074401 cgcaaataca caaatggttt tcatcttgtc atctccgcat ctatatatcg tgttaaacat 3074461 tcaaaaacac actatatatt gtcccatctt catgtgataa tatcaatatg aaatacataa 3074521 agaatgcagg agtgatgagg ttgcagctgg ctgatgcaga aaaatggatg aaagagtttt 3074581 acgaaaaaag aggctggaca gaatacggac cttttattcg cgtcggcttt ttaatggagg 3074641 aagccggaga actggcccgg gctgtcaggg cgtatgaaat cggcagagac cggccggatg 3074701 agaaagaatc gtcacgcgct gagcaaaaac aagaattgat tgaagaaatg ggagatgtca 3074761 tcggaaatat cgccattctt gctgatatgt atggtgtctc tttagaagac gtcatgaagg 3074821 cccaccaaga aaaactgaca aaacgatttg agcatgcata aaaaagcggc cgcgatggcc 3074881 gcttttttta acctgtgatt tcatcatggt gatcaaagaa atgctgcttt cctattttgt 3074941 gaaaaaggcc tgttttatgc agtagctcct tcggctgcga ttgcaatcct acaatcatca 3075001 gctttccatt gtggcgttta attcgattca taatgttccc aagcaccgct tcagctgacg 3075061 tatccatata gtgcacctta ttcatgagca gaataagggt tttcggtttt ttctgtacat 3075121 gctccagcaa tgacgattca agggaatcaa ttgatccgaa aaacagcggc ccttctatgg 3075181 catacatgct gacagatgga tcttctctct tcgccagaac aggatgcgtt tcctgattgt 3075241 ggatgcgggt cgcttcgctc attcttctga taaagaacac gaatgcaagc agcaatccgg 3075301 ttgccacacc gatgattaag tcaaacagaa ccgtaagggc gaaggtcgcc gccaaaataa 3075361 aggaatcagc atttttcagt ctcagcatgt ttgcgacttc cttgcgctca ctcatattcc 3075421 atgcgaccac catgagaatc ggtgccatac tggcgagcgg cacatgggac gcataaggcg 3075481 caaatacaag caggacaagg agaacgacta cgccgtgaac gacgccggaa actggggaaa 3075541 ccgctccgtt ttttatattg gtcgccgttc tcgcaatcgc tcctgtagcc gggattccgc 3075601 caaacagggg cgctgccata ttcgcaatcc cctggccgac aagctccttg ttgctgtcat 3075661 gctttgagcc cttcatgtta tcagcgacca ttgcggacaa aatcgactca agtcctccaa 3075721 gaagcgcgat gacaagcgca gccggaaaca gcataaccat tttatccaaa gtaagctcag 3075781 gaaactgaaa ttccggcaaa tggcggggga tttctccata agttgacccg atcgttgcca 3075841 tgcggtcagg gaaaaagaca accgcgacca ctgtggaaat aagaagcgcc aacaaagcgc 3075901 ccggcacttt aggcatcacc ttggcggata caagcaaaat gacgagcccg atcacagctg 3075961 tcaaaatggc atacacgtta aaggtgccga gctgctgcac aatttcaaac atgttgtgat 3076021 gaaagttctc atgtttttca acatttctca atccgagaaa attagcgatt tgttccgtaa 3076081 agatcagcac ggcaattccg gctgtaaaac cgacgataac gggtttgggc acgaatttca 3076141 ttatttttcc gagcttaaac agcccaaaca gtaccagcat cactcctgcc ataaaccccg 3076201 caatcagcag attttccaag ccgtactgca tgataatgcc gaataaaatc gggacaaagg 3076261 cgcccgtcgg accgccaatc tgatattttg atcctccaaa caaagaaata caaatccctg 3076321 ctataacaac agtgtatagc ccatattcag gctcgactcc cgaggcaatg gcaaacgcca 3076381 ttcctaaagg aattgccacg acacctacta cgatacctgc aatcaagtct ttctgaaatt 3076441 tctgcaaatt gtatcccttg aatctccctg agaatcgcat attttgttat aacctccctt 3076501 atgagtgatt gtttataagc tcagtttcat aaccgttaat gaccacatca agttttcctg 3076561 tttcagggtg aatgacaagc ccgtgaaccg gcactttttt cggaagcagc ggatggttct 3076621 taatcatgtt cacactgtgg gaaacgcttt cttccacgct gtgaaaacca gtcagccacg 3076681 ttttcaaatc gagtccggca ctcgtcagca aattcaggca gctatcctcc accccgcgtt 3076741 cctttgcttt ctcaagaatc gaggacgcat tcagccctga cattccgcat tcatgatggc 3076801 cgacaatgca tacctcttca gcctgcaatt cataaatcgc gaccagtatg cttcgcatca 3076861 cgcttccaaa tgggtgagaa acgatggctc ccgcgttttt tacaatttta gcatcaccgt 3076921 ttttaagccc cattgcttgc ggaagaagtt ctgtaagcct tgtatccata caggtgacaa 3076981 tgacgagctt tttcgaagga aactttgtcg ttttgtacgg ttcatacttc ttctcactga 3077041 caaaccgctg attgtgttcc aaaattgatg ttaaagaaac catttgattc atctcccatc 3077101 catatgattt tgcaagcctt cttacccagc ttacagtaag gaattatagc ataggaataa 3077161 gccaagaaaa ggttttcaaa aaaagacact ataattggac tgtagaatca aaacataaac 3077221 atttatatct ttcaaagata ataaaattta tatttaatgc atcctataat ccggctgcag 3077281 ttcgtatatc gatgatttgt ctgacaaaaa atatgggtga attctgataa ttaaaaaact 3077341 tttttaagca gatttagctg ttcgatcttc attttaagtt caaaagaacc agaaattaaa 3077401 aaaacgcagc tatattttta acatctattt attttcgata taatgaatta gacaacagcc 3077461 ataaaggggg agccttgttg aaaccatttg tatttatcac aaaaccgatt cctgaagaga 3077521 ttgaagcatt catcggtgaa cattgccgtt atgaagtatg gcaggaggat acgcttccga 3077581 gtgacgtgct atttgaaaaa ttaaaagaag cggaggggct tttaacatca gggacgtccg 3077641 gaccgtcaat caatcgtgag ttgctggaac acgcgcctaa gctcaaagtg gtcagcaacc 3077701 aatcagtagg ctacgataac ttcgatatag aagcaatgaa agaaagagga gtcgtcggga 3077761 ctcatacacc ttatacactg gatgacacag ttgcagatct ggctttttca ctgattctgt 3077821 cttccgccag acgtgttgcc gaactggacc gttttgtcag agcaggaaaa tggggaaccg 3077881 tggaagagga agcgcttttc ggaattgatg ttcatcatca aacgttaggc attatcggca 3077941 tgggcagaat tggagaacaa gcagcgagac gcgccaaatt tggttttgat atggaagtgc 3078001 tttatcataa ccgacatcgc aaacaagaaa cagaagacag catcggcgtt aagtatgcag 3078061 agcttgatac attgctggag caatctgatt ttattcttct cattacgccg ctgactgatg 3078121 aaacctatca catgatagga gaacgcgaat ttaagttgat gaagaattca gcaattttcg 3078181 tcaatatttc ccggggaaag acagttgatg aaaaagcact gattcgcgct cttcaggaag 3078241 gctggatcag gggagccggc ttagatgtat acgaaaaaga gcctgtcacc caagataatc 3078301 cgctcctgca gctggataat gtcacgctgc ttcctcatat cggttcagca acagctaaag 3078361 tgcgcttcaa catgtgcaaa caggccgccg aaaatatgct cgcagcgatc caagggcaaa 3078421 caccgaaaaa tcttacaaga gaatttcaat aaatcaaaaa tccggtctga taacagaccg 3078481 gatttcatat tacatacgct gaagaacagc acgcttataa atatgacggg tgacgatata 3078541 ataaagagcc tggaatacaa aataaatgaa gatgacaatt acggcctcaa gaaataaatt 3078601 ggaattcagc atattactta acgctgcata cgcaaagccc gcgtgaatcg tacctgcgat 3078661 aaatgggatg aagaataaaa atcctatttg ctttccaagg atcgagtgaa tctctttgtc 3078721 cgtaacccct atcctcttta acgctaacac ctgcactccc gtatcttcta tttccgtaaa 3078781 catccgcaaa tacagcatgc ttccttgcac gataaaaaac agcacgctga caaacagacc 3078841 aataaacagc attaatgcaa ctccctgctt cacaatttga taactaggag cacgtgtttg 3078901 aaaatcagat gtatgttctt tcggcaccat gttttcaagc ttttcagaga catccaccgt 3078961 ctcctgccaa tgctcaagct cataacctac cattctcatc tgttccttca gcggcacatc 3079021 ctgtgacaga ctgtcaaagc tcttttcgct gacaaccaat aaacggctga ctccatcgac 3079081 agacatcaat atccctttgt tttgctgctt tttcatgaca taggaaaggg tttttcctga 3079141 cttcatatga aatgctgctg tttccccttc tccaaatgtg tctttcacca tcatttgaaa 3079201 agaaacatta ataaatgctt cattttcttg taaatgaata actgggaacc ctttttcctt 3079261 tgcgacttga ttatagactt tttctgaaat cagcaaagct tcagcttcca tcttcttatt 3079321 tccatacggc aagtctgact gaaaagtgac aggaatccct gtggcatcca ccttatacgt 3079381 gataacagca tgagcttttt tcaatgtatt ctcagccgtc tcaggcttca tgacctgaaa 3079441 gcgggaagca tccttttcca cccaggaaac agactgagga atgctttgct cctcctgcct 3079501 ttgtaaatcg gaataaaaca tatagatgac acctgtagct gttagtatga ccgctgtaat 3079561 gacagaggtt aaaaacagca tgcgtgcatg atccttcagc ctgaatatca tgttggaacg 3079621 cacaatgata tttgtgcctt tgtagaagct gtgtttcttt cggtacagca tgcggaaaaa 3079681 tgccacactg ctttgggtaa aaaagaaata cgtgccaatt aacactaaaa tcaaaattgg 3079741 aaaaacccga aacatcatgt caattgcatt ggctgttgca gatagataat aaccgctgcc 3079801 aagacatagc aaagacaata cagtgagcca tttcgaataa actggcaaac ttttcggctt 3079861 tttggctgat ttaatcagtt caatgatttc cagcttccga atccgtccca gtgataaaat 3079921 gagcagcgtc tgaaacagga tgagaaagcc ggcaattgtc atcacaaacg ctttcggcac 3079981 aatggcaaac gaaatcggca ccttcacgct gagcatccat gtcatgatca taaaaaacag 3080041 ttttgaaaat aacaggcctg ctccaatgcc ggccgcaatc gccgcaagag aaataagtga 3080101 ctgctcataa taaatcatct tgcgaagctg ctgctttgat gtgccaaaca gtgtcagcag 3080161 cccaaactct ttctttcttg cctgcaaaaa cgctgaattg gaatatgtga tgaaaaatat 3080221 acaaaacaca atgatgacga caagagctgc gctcaagcat gttttgacaa ggcttcctcc 3080281 atatatattg tcttcattga catcaggatg aaaaataaat gatgtgaaga caaaaaacac 3080341 cgaaacggca aacacacagc ttaaaaagta ggccacatac cgttgcagat tcccaagaat 3080401 gtttttacgg gcgatagttc tcaaattcat gaaaatcgcc tcccaacaca ctcaaggtat 3080461 ccaatatact ttgataaaac acctgcctgt ttgttcctct gtgaatctct gaaaagaaac 3080521 gtccgtcttt aataaaaaca atccgtttac agaaacttgc tgctgtggca tcatgcgtaa 3080581 ccaacaaaat cgtcgcttcc ttttcctcat tcagctgagc cagtgtgttc atcacttgct 3080641 ttgccgattt tgagtcgagg tttcctgtcg gttcatcggc aagaatgagc gccggattgt 3080701 gaataatcgc tctggcacaa gctgcccgct gctgctgtcc gcccgacacc tcatatgtgc 3080761 ggtgatcgag aatatgcttt atttgcagcg tatccgccag ttcatccaat cgagcttcca 3080821 tttctctcag ctttacctta tccaatgcga gcggcaagag aatattttca cgaatcgtca 3080881 gcgtatcaag cagattaaaa tcctgaaaga cgaagccgag ttctcttctg cgaaacaaag 3080941 ccagctcttg gtcctttaac gttttcggct gaatgccgtt gatcatcatc tcgccctggg 3081001 tcggcttatc aatggtagcc agcaaattca aaagcgtggt ttttccgctt cccgacggcc 3081061 ccataatccc gacaaattct ccttttgaca cactgagatc aaaggcgctg agcgcttggt 3081121 atgatattgt tcctttattt gaatagtatg ttttcgatag gttcgttgtt tgcaacacgt 3081181 tcatgttctg ctcctccttt ttctttatta taaaaaggaa gtcagcatcc tcccatcgaa 3081241 ctttcttgca attccgctcc ccaatcttac aatgctgtca cattcacgag ggtgtcactt 3081301 gaaaacacga tggtcatcac agtgccagcc ccttcttttg attccgcata cagcttatgg 3081361 ccgagacggc tgcacacctg ttttgctaaa taaaggccca ttccagttgc ctctttcatg 3081421 gttcgtccgt tttctccggt aaaaaacgcg tcaaaaatcc gcggcagatc ctgcggcggt 3081481 atgccgattc cttcgtcggc aaccgacaag cgcgtctcat gtccctgtgt ttcaatccgg 3081541 attgtaatag ggtctcccac accttgcttt gaatatttta aggcgttgaa aaggatttgc 3081601 tcaacaacaa aggaaagcca cttttgatca ctggaaatct gaacggcatt tggcggcaca 3081661 tgtaatgttg gaaaaaggcg ccgcttgata aactgacgtt tttcctgatt gatcagtgaa 3081721 cgaaccattt ctgccaaatc aaaggtttgc ggctttacat caaatgcaaa ttcctccagc 3081781 cgggccgttt gcagcatcat atcaagaccg tggcgaaatc tctcattctc atcctccagc 3081841 tcctctaaaa acgtcggaaa agaggatgag gttccgtttt ttccttcctg aatcattaag 3081901 gatatgacag ataccggtgt tttcatatgg tggacccatt ggttggtgaa ggtgtaatgc 3081961 tgtttttgct gattgatata ttgtgagagc ctgctttcgt attgctgccc gagtgcgttg 3082021 atcatcttcg tccaaagcgc ttgctctcct gttcttggct ttctggcttt caaagactgt 3082081 ccgatgtcat tcgaagaaga ggcttgttct gcaagctttt taacatatgt gagaaaggaa 3082141 aattgccgaa cataatcagc agcaaaacct gcggctaaaa gagtaccggg caaaatccat 3082201 atgtacatca tattttcttt ggaaggttct gcgccgctct ctacaatgct taaatacgca 3082261 atcagcatgg cggaccctat ccctaataat gaaaatagaa taatggctaa gcggtcgatg 3082321 agataagtct ttaacattcc gcttcatcct tccgattgac ttgaaattga taaccttgtc 3082381 ctctgattgt ggaaatgcaa tctgtcagtc ctgcattctc cagttttctc cgcagccgat 3082441 tgacattgac cgttaacgta ttgtcatcga caaaatcaac gtcatcccat aacgcctcca 3082501 atagttcatc acgagagaca atttttttat gctccctcac aaaaatcgag agaagctgga 3082561 attctttttg ggaaaacaaa atccggacgc tgttccattc ggcctcattc tgatcaggat 3082621 aaatcgtcag cccgccaagc tccactattc tagattcctg cggcaaagag ggcgaatatt 3082681 caccatatgt gcggcgcagg acgcttttga ttttggccat cactacctct agatggaacg 3082741 gctttgtgat ataatcatcg ccgccatttt caatcgccat tacctgattc agctcatcgg 3082801 tccgtgccga tataaagata atcggcgcat tggaaatggt acggatttgc ctgcaccaat 3082861 aaaacccgtc aaaaaaaggc aggttgatat caagcagcac aagatcaggc ttcatttctg 3082921 caaattccaa ttttatatca ttcagctgtt cagcaatttt cacttcatat ccgtattttt 3082981 gaagatgacc gcccagcaaa gaagcaatcc gctcatcatc ttccacaagc aaaatccgat 3083041 acacgttgat cccccttata tgtacatcac gatgattttt ctagaagatt ccaaaattat 3083101 tatagcatgt gcggaatagt aaatcggtct ttttcttttt gttatgatag aatgataaag 3083161 gtaaaatttt cataataggc aggtgtcgtg atgaagaaaa tcatgctgtt tctggcaatg 3083221 acgtcaattc tttcagcatg tcagcccaac tataccggga aatacataga aattggggat 3083281 acactaactg actataccaa agagtgcttt aaagagaatg aaattcctta taaatacgaa 3083341 aagggaaaac tgtatatccc agaagacgca tttgatacag caatctacac ttgttcataa 3083401 gaaaaagctt gcagataacc tgcaagcttt tcacgttaca aaaaatgagt atttaatttc 3083461 tcttcaaatc ctgaagggcc gatgtcgctt ttttgaatgt taccgccgtt ttcataaatc 3083521 gtaaaatggc gctctgacat gaccatcctt ccgctcggcg tcagctttga ggcaagcagg 3083581 gatttgttaa aaggagattt ttcatgagag tgaatgatgt ccttcatgtt atctaaatca 3083641 ccgagatcac tctcttcaag ggtaaaggcg tacccaattt gccagccttc tcctttgtcc 3083701 atcagcagaa catagctgcc cttttctgtc tcttcctttt tgattcggaa tgacccgact 3083761 ggtgactgta ccgtttctcc ggaaagcggt atcggctgga gcgccaggtt gatgccgaag 3083821 ccgatatcaa cgaggtaatc gccgttttcc gcagacagcc atacagcagc atgcgtccct 3083881 tctagtgccc atccctcttg atcgcctgca taaaccgttc ctcgaatgag cttcacatga 3083941 aacccggcct cacgcaagac aaaataaagg aaaccattta gatcgtagca taggccgccg 3084001 tgctgatctt tgagcagacg tcgccatagc tcttcttttg tgatcttata attctctttt 3084061 gcaagtacgg cacggttttc gaatggaaaa cggtatgcca ttgctttaag aaaaagggga 3084121 agatcgccga agctgacatg gtctttctcc cagccgattt tctgaaagca gtcttttaga 3084181 aagtcactca tttttatcac ctaaacttct tcttgaacgt aagcagccag cttctccagc 3084241 gcctcttgtt catcttctcc ctgggcaatc aaggtaacct cagtgcctgt gcttaccgca 3084301 aggctcatca gccccatgat gcttttggcg tttacttttt tcccatcctt ctcaagaaac 3084361 acatctgacg taaaccggtt tgcttcttgt acaaacaaag cagcaggacg tgcttgcagt 3084421 cctgtcttta atcgaacttc cactttctgt tgaaccataa gatctcccct tttctttacg 3084481 gttattttaa agtgacggtt tgccctgtcc gcagctgttc tgcgatttcg tcaagttttc 3084541 tcagcctgtg attgatccct gatttgctga ttttcccgct tgctaccatt tcccctagct 3084601 ctttcagcgt cacttcctga taatcaatcc gcagctgcgc aatttcccga agtttttcag 3084661 gcagcgcctc caggccgatt ctttcatcga tgtatttaat attttccacc tgtctcagcg 3084721 atgcgccgat cgttttgttt aagttggctg tttcacaatt gacgaggcgg ttgaccgaat 3084781 ttctcatgtc ccgaacgatt ctgacatcct caaatcgcag aagcgaattg tgagcgccaa 3084841 ttacgttcag aaactctgta atcttttcag cctcttttaa ataggtaata tagccttttt 3084901 tccgttcaag cgttttgctg tttaactgaa actcatttaa caggtcacat aatgaatcgt 3084961 tatgctcctt ataaagagag aagatttcta aatgatacga ggaggtttcc gggttattga 3085021 ccgaacctcc tgccaaaaat gctcctctca tataagaacg cttgcagcat ctctttttga 3085081 ccagctcttt cgaaatactt cgttcaaaca caaaattctc cccgagtatt tttaaatcct 3085141 ctaagatcgc ttttgcattt tctgaaaaac gcacaatata gacgttattc tttttcagcc 3085201 gcattttctt tctgaccagc agctcgaccg acacatcata ttgttttttc agcaatgtat 3085261 agatgcggcg ggcaatcgcc gcgttttcgg tttgaacatc gagtacgaga tggcggtttg 3085321 taaatgataa agctccattc atccgaatga gtgcagacag ctcggcatta atgcagcagt 3085381 ccttcacttc cagattcgtt aattcttttt ttgtttctga tgcaaatgac atatagccac 3085441 ctcatttcaa ggcttcattc tttcagtaaa tcaacaagaa gagaggccac tttatgtgta 3085501 tcgtgacgta ttacgtcatt tttatacgtt acaatttgat ctctgatgac ttcaagcccc 3085561 atcgctttca gctcttcgat atcaaaatca acaggacgcg ccgattccat ttcgtactta 3085621 cgttttattt cgtcgggaat gtcttcactg ttcactaata tcgtatcaat aaaaccacag 3085681 cccatatgct gattgagcgc tttcacatga tcagcagcgg tgtaatggag cgtttcgccg 3085741 ggctgagtca tcacgttgca aatgtatact tttttcgccg gcgcctttat cacttcttcc 3085801 ccgatttttg ggacgagcaa attgggaaga atgctggtat agaggcttcc cgggccgata 3085861 ataatcaaat ccgcttccct gattacgtct attgtttccg gcagcggatc aatctgttca 3085921 ggcgtgagaa aaacacgctt aatgcgctgt ccgtattctg ggatcgttga ctcgcctgag 3085981 accacgcggc catcttccat ctcagcatgc aaaacgacac tggcattggc agccggcaaa 3086041 acctttcctc ttacattcag caccttgctc atttctgtga cagcgtgaaa aaaatcaccg 3086101 gttatatttg tcatcgctgc caaaatcaaa ttcccgagag aatggcctgt taagtcattc 3086161 cctttattga agcggtgctg aaaaagatct tcaacaagcg gctccacatc ggataaagcg 3086221 gcaagcacat ttctgatgtc tccgggaggc ggaattttca gttcattccg cagacggcca 3086281 gagctccccc catcatcggc aactgttaca atggccgtga tgtcaacggg tttatgcttt 3086341 aggccccgaa gcaatacaga aagacctgta ccgccgccaa agattgcgat tttcggcttt 3086401 tgtcccatct tatttccggc ttctcttttc aatgtcccgg tgagtaacat gagtatagta 3086461 atcctttttg aaataatcag ctaaattctc ggctaatgtc acagagcggt gctggccccc 3086521 tgtgcagccg atcgcaatga caacctggct ttttccttct cttttgtaag atggaagcat 3086581 aaagctcagc agatcaatta atttctcatt gaacttttgc gtttcattcc acttcatgac 3086641 gtaagaggaa acctctttat ccttgccagt cagcggccgc atgctttcga tatagtacgg 3086701 attcggcaaa aatctgacat caaagacgag atctgcatca attggaatac cgtatttaaa 3086761 accaaatgac atcacattta cggtaaatgt ctctccttgg tttgtcgcaa agtgcttcac 3086821 gattttttca cgcaaatcac gcggcttcat gtcagacgta tcgtaaatga tttgagagcg 3086881 gccttttaat tcctcaagca gctctcgttc tagcgcgatg ccttcaagcg gcaggccagt 3086941 cgctgccagc ggatgcgagc gtctcgtttc tttatatctt gtgacgagaa tggaatcctt 3087001 cgcgtccagg aataaaattc gcggtgtgat ccacggattt tcggccattt catccagcgc 3087061 ttcaatcagc cggtcaaaaa attcgcggcc gcgcaaatcc atcacgagcg caactttgct 3087121 cattttcgaa tttgattcct tcatcagctc taaaaacttc ggaagcaatg aaggcggaag 3087181 attatcgacg cagaaatagc cgagatcttc aaagctttgg atcgcgacag ttttccccgc 3087241 tcccgacatt ccagttataa tgacaagctg aatatcatgt gattcactaa cactcatctt 3087301 tctcccccct gacttgtctt tctatttgat gtgctgcggg tctaaacgat aactgagcag 3087361 ctcaaattcc ggtgtatacg taaatgtgcc gtgcagcagc ccttgtccct tcatcataaa 3087421 atcaaggata tggccgtctc caggggccat aggcaggttc tgaatgtcat tgacatcgtg 3087481 ccactgcagt ttgccttcct ctgattctga tacattttgt cctgtatatg aatcagcgac 3087541 aaacgtaaac atcatccact cggagacaat gtggtcaccg tctttaataa taaaggtaaa 3087601 aacgcctttt aattgaggat ttatgatata gataccagtc tcttctctgt actctctgat 3087661 gacggagtct ctgactgatt ctccgctctc catcttgcct cccggcgcga cccaccatcc 3087721 gcgtctcggc ttttgaagca gaagaacttt gtcatccgtc tgaagcacac aatttgtcac 3087781 tctttgcaag tacgtcacct aaccttcgtc ctgtcatcgt ctctttatta taccgcttca 3087841 agatgcctcc cacaatgaag agacattgac aatcttttct tctattttac agcatattca 3087901 ttccttaatt cagatgattt tgctgtaact ggaattctct tttatttatg gacaaaaaaa 3087961 ggacacggat aactggagaa tccgtgccaa aaaagtgtat tcattataaa aagggggtca 3088021 attactttat taatcataac cgaaaagcat tacacatgtg ttacagcgga attaaaaccc 3088081 agtaacgtaa tgtgaaactc gtatgacagc cctttttatt ttaaggtttt cagcgtttct 3088141 tggagctctt cgacataatg ttgtacgctt tgtgccgcaa tgcttccgtc tcctgtagcc 3088201 gttacgattt ggcgcagtga tttttcgcgg atgtctccgg cagcgaaaat cccttcaacc 3088261 ttagtttcca tgcggtcgtt tgtttcgata tagccttctt cattcgtaat gcccaggttt 3088321 tcaaacggtt tagacagagg aagcatgccg atgtaaatga atacgccgtc tgttttgaat 3088381 tcactttctt caccggttac cgtatcgaca agcgttacgt taccgacttt gccgttttcc 3088441 tcatgaattt ccttcacagt tttgttccat aggaagtcaa ctttttcatt atcaaatgct 3088501 ctcgcttgaa gaatactttg agcacggagt ttatcacgtc tgtgaacaat cgttactttt 3088561 gaagcgaaac gagtcagata tacgccttct tcaaccgcgg aatctccgcc gccaacaacg 3088621 acaagttctt tgcctttaaa gaaagcgccg tcacatactg cacaataaga tacaccgcgt 3088681 ccgcccaatt ctttttcgcc aggcacgccg atttttttat attccgcacc tgcagcaatg 3088741 atgacagcac gggctttata ttcctttgaa ccagctttga ctactttgta ctctttgccg 3088801 tcaatgacct ctttaatatc gccataagcg tattcagcgc cgaatttttt cgcgtgttca 3088861 aacattttgt tagaaagctc aggcccaagg atactttcga atccaggata gttttctaca 3088921 tcttccgtat tggccatttg tccgccagga attcctcttt caatcattaa tgtcgataaa 3088981 ttcgctcttg atgtgtatac agcggccgtc atcccagcag ggcccgcgcc gattataatc 3089041 acgtcataaa ttttttcttc tgacacacta ttcactcctt aaaccatctt ttcaagtttg 3089101 ggctctttct tataagataa gaatccccat caaacgtatt ccttacccat atcctataaa 3089161 atctcatggt gatacgctat ttttttgctc aacacgatta aatgtattcg aaaagggtat 3089221 atgttaataa agaaagagcc ttctgtttat agaaggccct tgtcatattt attattgaac 3089281 aacacgtctt acaacacctt taaatgctgc tttccagtaa ggattgctca tagagtcaac 3089341 agatacgcca tgagatgtat tgtcgtttag gaaagtaccg tttcctaagt agattcctac 3089401 gtgtccattt gttttgtaag tgtcaaagaa cacaaggtct ccgcgtttca tttcagacgc 3089461 gctgacagct tgtcctctgc caactaacgt atcagttgtt gttccgccta caggtccaag 3089521 gttaacacct gcagaagcgt atgcccagcg tacgaatgat gagcagtcaa aaatacggtt 3089581 gttgatatca gactgagtgc gtccgccgcc aaacttgtac ggagattgtc ctacaatgct 3089641 tgaaccaacg ctgatcgcgc cttcaattcc gccagagttg ctgataacag tgccgcctga 3089701 attgctgttt gagccgctgc tcttcttaga agatgagccg tttgacgaac tgtttgatga 3089761 accgttagaa gaattgtctg aagaattgtc tgaagaatca tcagatgagc ttgcttttga 3089821 tgattcagtt gtcgccgttt gactgtcatc tgtttgtgtt tcatcagatg ctttttgtgc 3089881 ttcttcctgc tttttgatca aagcagccgc tgcttcttgt tcttttttga tgcgtgcttg 3089941 ttcagcttca gtatttgctt tttgatttgc aagttcagac gcctctgatt ttaattcaga 3090001 aatcgcttta gccgttttct tttggcttgc ttttgcttcg tcgaaaagct tgtctttttc 3090061 attaagctgt ttatcaaggt ctttttgcat tgtttctaat ttagccaagg cagcttgaac 3090121 ttctttcagc ttgtcattca aatccgcttc agaatcttcg agcttcgctt tatcctgctc 3090181 ttgctgtttg attaaatctt tgtctgcgtc cacaatagat gaaaccgcag tcgcacgaga 3090241 gataaagtca ccaaagcttg ttgatcctaa aagaacatct atgtatcctt gagatccgcc 3090301 gctttcctgt aaagaacgaa cgcgtttttt caggatttca ttgcgttttt cgatgcgtgc 3090361 ttcagtttct ttaatctctt ttttcagttt tttgatttct tcttttgttt tatcgttttc 3090421 ttctttttta tcttcaatct tgttgcttgt atcaagcgcc ttatcgttaa tgtctttcag 3090481 ttctttttca atctttgatt gattttcctg aagctcggtt aattcttttt ccttcgcttc 3090541 aatgctggaa gcaacctcag attgcttgct ttcgattttt tgtttctttt catctaatgt 3090601 ttccgccgat gcagttttac ttgtaaatgg gatcaaaaaa ctgcttgtcc cgatgacgga 3090661 agccaaacca agtgtaatta aactctttct cactttttat atcctccctt ttactgtgaa 3090721 cctgtcctca tttggaatcg tattttgaac atcaagtttc gttcctcata ctctacgagg 3090781 aatgatggtt gtttatggtt aattattctg tgcatctctt attctggttg tatagcgttt 3090841 atttcacatc atatgtaaaa aacactaatt ccttatgtac gagaatcatt ataccatcaa 3090901 gtttcgacaa attagcgata aattttatta catttatgtt tcaaacagat gtcaagtcac 3090961 acatcatttg tcatttttct taagcgtgta aaaaaactgt cgatattatt ttcttaatat 3091021 aatctatcta acaaaaaaag agtcgattaa ataaatcaac tctttaaaat ttactattct 3091081 agaatatcat caatatattt catatatttc gtcaaagttg ccggagagat gccgaatcgg 3091141 gccgctgtgt cttttttcgt gtcttgcttg ccatgggctt ctttccaaat ataacagatg 3091201 gctgctgccc agcctttctc attcttcaac ggagcagctg cacgaatttg ctggatgaca 3091261 tgaaaaaccc agcagctcat gacttctgtt ttcatctctt ctttttcagc ttgctctaat 3091321 agtttgaccg tttgataagc gaaaagtgca tcctctgaaa cgtcagcagc cgcagaatct 3091381 ccattcagaa gcagctttac aaaatgagtt tcaaaaggag cggtaattct ctttgagcgt 3091441 atcaccgctt caagatgctc tgtttctccc tttgtgctgc tgatataata ggctgcgagt 3091501 cgctgctcca cagatgaagg aagagcttcc ctccgctcaa tccaaggcgc cgggcggtct 3091561 tcgccgggat attgcgactc gacttttctc cagatcgtct cggcaaagtc ggtatgtccc 3091621 gtaaaataag cagagcagga aagccagtaa aagaaggtgt cgtcaccctc aaagccggtt 3091681 ttatataatg atttgagcca tttatatccg atctcgtagc ggccgacaag cgccaaagta 3091741 gcacccaatt tataacgctg ctccaatagc atcggataga cattggagag ctgatcactc 3091801 aattccgcca ctttttcgtc ttctctttca taatagtaga aaacgagaag attgcataag 3091861 gcgtgaagat ttccttcatt atgagaaagc acttcataag cggtttgctt cgcttttaca 3091921 acgtttcctg aatagaaata ggcaagcgcg agattgttgt atgctgacca aagctccgga 3091981 tattcagttg tgatttcctc aagcgccgca accgcttcag caagctggcc gctttccagc 3092041 aatgactttg cccgatcctg tttcaccagc agttcatcct gatcatacaa cgaatcctca 3092101 atgccgtcgt ctcctaaatc gagcaaatca agcagactat cgttttcttc ggcgaattca 3092161 ccatccgggt ccgcatcaga ataagcggcc gcttctttat aagcttcctg gaagagcccc 3092221 agatgggcaa agttattcgc tttaaagtaa tggcactccg gcatttcggc ctccagattt 3092281 gccatgatat agtcaagaag atcgttcgac tcttgatact ggcccatttc cgaataaatg 3092341 accgcaagct gtgaaagcat ctctgaatcc tccggctcca aatgaaccgc gcgctgaatc 3092401 agtttgcttg cccgttttag attgcgctct ttatacgctt tcaagccttt atgaaaaaaa 3092461 tattgtccat cttgaagcag ctggacaatt tgtgcgtgat ttttatgttc agaagtgtgt 3092521 tttcccacaa ctaccctccg ttttatacaa tattaccgtc agtagtatac cataaatcgt 3092581 aagcccctca atagttcaaa aggaaggatt gggaaaatcc ctcctctttt ttattggctg 3092641 attcgaccaa aatttacccg gctttgtttt ctaagtccgc attcattttc agctgctgtt 3092701 cagcaaaatc ccggtaaagg ccatgggaag ccattaactc atggtgtgtt ccacgaccgg 3092761 taatttcccc tttttcaaca aacaaaagct ggtccgcatc tacaacggta gataggcggt 3092821 gagcgataac aatcgttgtg cggccctcca tcagcacctc cagcgcctgc tgaactgatt 3092881 tttcagattg gctgtcgaga cttgaggtag cttcatcgag cataagaatg cttgggttac 3092941 ggagaagcgc tctcgcaatc gcgattcttt gcctttgtcc gcctgacagc ataatgccgc 3093001 gttcgcccac ttctgtatca aactgattcg gcagctcctt tataaaattg agcgcatatg 3093061 ccatctccgc ggctttttcg atctcagcat ccgtcacatc tcgttctaac ccgtagcaaa 3093121 tattttctct gattgtcccg gacattaacg ggctttcctg tgatacatac ccgatatgct 3093181 ccctccacga ttcaagcgag taagtatcga ccggctcgtc ccccagccga atggtccctg 3093241 cagtcggaga ataaaagcgt tcaagcagct taaacagcgt cgtttttccc ccgccgctcg 3093301 gaccgacgat cgctgtcact ttccctgctt caatgacggc gctgacctct tttaagatca 3093361 gctgatcagg cttatatcca aaagacacgc gatcaagctg gataggcaga tgtgcatttt 3093421 caatttgttt tcctgtcact gtatcttcct cttcctctgc caaaatctca atcattcgtt 3093481 ctgttgcacc gattgatttt tgcagctgtg tgaaaaacgt tgtaatctgg cccatcggca 3093541 taataatttg aaacaaatat aaaataaaag ccacgagcgc tccggctgtg agctcgcctg 3093601 atgagacctg catgccgcca tatccgatca ctgcgacaag cgctgccatt aacacgagtg 3093661 aaataagcgg gccgacaagc gattgaacct tggcttcacg aacgccaagc ttaaataatg 3093721 aggaaatccc catcttcccg cgcccatatt cgacatcctc cgcatttgaa gccttaacaa 3093781 gtctgatttc cgggagaatt tgattaagca ggcctgtaaa acgagccgtt tcatcttgcg 3093841 tttcccgtga aatggagaac attttccgtc caatcggcac caaaataaga gcggccagcg 3093901 gaacgaccac taacacaagc agtgtcagct tccagttcat aataaacaag attgtcaatg 3093961 atccaatgac agaaatgatg cctgtaataa atccgctgat atgggttgta atcaattctt 3094021 tgaccaccat cgtatcgttc gttacacggc tgactgtttc tccggaagca tttgtatcga 3094081 aataagagac aggcagctta attaatttct tccataataa ctcccgcagc ccggaaatga 3094141 ttttttgtcc attatagtta agcgcatagg tggcataagc gcttaaaccc gcctgaacga 3094201 aaaacaccag cgcgatcaaa ccgatttgcg tgcctgacag atttgacata gaaaaaccat 3094261 cgacaagctg cttcgttaat aatggaatga gcaggctgac cagcgtggtt actacactga 3094321 gggcaagcgc aaaggcgagc tttccataag aaggattggt ccgtcttact aaggcaaaaa 3094381 agggtttcaa tttactttta gatttttgtt tcttggttgg catatatttt cctcctgttt 3094441 cagcgttcag aaaggtgaaa agtcatagca aaaggatgat ttttactctt tctcaatcat 3094501 atcaatggag aaagactttt tcagtatatt tttgccgtga tcaaaataaa aatctcccac 3094561 tcattgtttg aataggagat ttttgtgtta gacatctttc actggcttct tttttctgta 3094621 agtcaatgtt acatcctgct gtcgcaggtc ttctattatc attttgtacc gatcaacttt 3094681 tgcggtatgt tcttctttta tcatctgaag ggcagctttt cgtttttcgc tattagactc 3094741 aagctctttt tttatttttt ttacaatcaa ccctttttgc cctttgattt cctcttttaa 3094801 tgaagactca aatttctttg tcaggctgag aaagtcgttg atcggttgat tgagggtgcc 3094861 cgctttcccc ttcatttcat cttgggtaag aaacatatag gtcgttgata caatttctgt 3094921 ttcactttct gaaaataagg aagtcactct tcatattcct cctaagactg aaaatcaaat 3094981 aactgagaaa tcatttcttc tttttcaaac agcttttcaa tactctcgcg gatatttttg 3095041 ataaaatctc ttttttctgt tgtctgtttt tttaattcag caacaattcc atcatttgca 3095101 ggaagcgcac ctgtgtggaa tgattcatga actgagattt tctccaattt atcgaatgtg 3095161 tggctgaaac cagctgcaag ccggaattga agatcgaagg cataatgcga agggttttct 3095221 tccatatgat gaatagccgt gatgatcgcc tgctttttgt ctatgaagtc ttcatcgatt 3095281 tcctgactgt aaaccttctg gtacttagaa atcgcatctt ccatatcttc aacgattttc 3095341 ataccgtttt gatagattct gacagcggat gagagattga cttgaatcgt ttctcccgag 3095401 ccactcttcc ctgtaaaata aatatcggag cctttatagc tgaagccttt ttcctttgac 3095461 aaggcgttga gcatttgaac gatgctgtgg ccgtcgacga taagttttag tgcgtctttt 3095521 gtttctgtgt cgagtgtttt caatgaggac agaattgatt ttacatagtc cactatttca 3095581 ccaacgtctt ttaaagcttg cataaattgg ccatgtttta gatggtctat gaaatgttcg 3095641 taccgtgact ctatgcctcg catactcgca ttaatattcg ttaattcttt tttgatgact 3095701 ttcttttgcg tttcatcaat ataaccattt tcagctaact gatctacgac cggtccgctg 3095761 tttctcaaca aggtatgaag aaaacctaaa aacgacggca gttcctcttt tattcggcca 3095821 tacatttgct taacatcatc aaaatgctca tataggacac ttactttctt taaagcgccg 3095881 tctgtgtttt tcactttttc aatcaggtct atgtctatcc cgctggctgc ctttataaaa 3095941 ccgttcaagc cgtctttttc atagtcatcc ttatattttt gaaggaattt ttgaattgac 3096001 ctcacatctt cgtcaggaac cccatccata atgtttcgga tgccttttac acttgtattt 3096061 gtatctgcca tcttcacatc accgaatgta ataaaatcgg ccttgccgct gactccatac 3096121 agcgggtcat cttttgagat gcgctgagtg atgtttgttg ttacgccttt gtcttcataa 3096181 tatttttgga tttctttttt taacttttct ggcgggatgg aatctatatc ttcatattta 3096241 taactaaatt tcctaataac atatctatat aaactttcat cagtttcaag taattgatca 3096301 atattgactt gagctccatt taccccataa acttcatcat attctccatc aatcaattgc 3096361 accataactt ggttattatt tgcaagtgaa tgtcctaagg cgaatgtttt taaatcctca 3096421 gagttacctg ctgctttctt tgctttgtta gtaaactcct ttgtagcctc atactgacta 3096481 tgatcaattc ctaaaaaaag accaaaaaag ttatatgacc aatccttatt atcggcacta 3096541 ccttctgaaa taatctgaag ctgatcaata tgttttttct catctattat atggattgcc 3096601 gttccatcgt aacctgattc tctggtcgaa ctttgtatac ttgtattctg atttacaagt 3096661 tcattggagg tgtaaatttc aattttcata ttctcaggaa gatcgtggtg ggtttcctct 3096721 ttataaattc tgcgtatatc tgcttcgaaa tccttcttag ctttcttaac ttcactcgca 3096781 atagttgagg caaacttttg tttatagtca tattctaaat caattaacct taactttacg 3096841 ttctcattct caaatacatt tttatttccc atcttatttc tcctttttat ctattaaaaa 3096901 ggtgatagaa ttaattaatt tctcaacttt atttttagcc ttttcttcat ctaaggagca 3096961 tggttgattt tcatttttgc atccaagggt aaaggcgtat tctactccta ggttatcttc 3097021 ctctgtagac ttaacatatc caaaataact gtatgaataa ttatattttc tatcaatatc 3097081 gtcaaagatg tcttttttct tggcagtgta aatatccgtt ttctttttgc tgcttttttt 3097141 gtattcgcct ttataatcat tttttccact aacaatatct agcattgtct taggttcatt 3097201 cgcaaaactt tcttctttgt aatatgttac atggccatca aacattacat tggtgtcttt 3097261 atcataacta ttaaatccaa tactttcttt gtttttcccg gttaacgatg atcttcttga 3097321 tagatacttt ccatcctccg gaaacaacat cctaaaccct ttcagcttag attccagcaa 3097381 ataatatcct ggttcctctt cttttgttga caccatgtac tctctcgttt tctcgtcctg 3097441 aaacgcaggt acttgaggca gatccttggg atccatgtct tttggtttta ccgcttctgt 3097501 tttattgtca tttgtgctgt ttttatcatt gtcattcata ctgcatcctc ctgtcagggc 3097561 aagtaataag ctgaagcaaa taaagatgat ctttttcatt acgaacctcc acgggttttg 3097621 tgagaatagt attctatttt tatatcaaaa ataattctat tgacctggtt aagagatgat 3097681 tatttcatcc tttttcatgt tacatcatgg cggaatttgg ataaatagga aatgagactc 3097741 ggttttgatc tccttttatt aactaatcat atataacacc caatataaat ctaaatacct 3097801 attacttttt tcacaaaaca aaaagagccg tatcatccgg ctctttactc ttcaatctca 3097861 gaatggcgtt ttttcaatac gtcaagcaca tcatccagcg gcagggattg ttctctgagc 3097921 aggacaagca ggtgatacag caggtctgcc gcttcccatt tgagttcctc atgatcccgg 3097981 tttttcgcgg cgatgatgac ttcggatgct tcttctccga cttttttcaa aatcttatcg 3098041 acgccttcac ggaagaggta cgtggtgtaa gctccttcag gcatttccgc ttggcgttcc 3098101 gcgatcaccc gctccagttc gttcatgatg ccgaatcggt ccgcggcctg ttcttctgtt 3098161 tgttcctttg taaaacagct gtagctgcca gtgtggcatg ccgggcctga cggttctacg 3098221 agtacgagca gcgcgtcttg atcgcagtca taccggatac ctttgacggc ttgcgtgttc 3098281 cctgaggttt ctcctttatg ccataacgct tggcgtgagc ggctgtaaaa ccatgtttcc 3098341 ttcgtttcca gcgttttttc gtacgattcc ttgttcatat acgcaagtgt cagcacttct 3098401 ttgcttgccg catcctgcac gatagcagga attaatccgt cctcgttaaa acgcagttca 3098461 tctgcctgtt tcatctcaca ttcaccccgt actctttcaa gtatgatttc acttctttaa 3098521 tcgatgtttc tttataatga aaaattgagg cggccagcgc ggcgtcggct tctccttttg 3098581 taaaagcctc aagcatatgc tgtgcgtttc ccgcgcctcc cgaagcgata acagggacgg 3098641 ggacagcttc ggaaacaagc tttgtcagcg tgtggtcgaa accttttttc tcaccgtcgg 3098701 agtccatgct tgtcagcaat atttctcctg ccccgcgttt gacgccttct tttgcccacg 3098761 cggtgacctc ccaatctgtt ttctttctgc cgccgtgcgt gtagacctta tatgtgtcag 3098821 attctttgtc atacttggca tcaatggcaa gtacgatgca ttgagaaccg aaaaactcgg 3098881 ctccttctgt aatcagctca gggcggagaa cagctgccgt gttcaccgac actttgtccg 3098941 ctccggcacg cagtatcgtt ttcatatcgc tgagctgatt gatgccgccg ccgactgtaa 3099001 acggaatggc aagcttcgcg gcaacctgct ccacaacgtc aaccatcgtc tttcgtcctt 3099061 cgtgcgaggc ggagatatca agaaaaacaa gttcatccgc accttcccgg tcgtacactt 3099121 cggcgagttc aactgggtca ccggcatcct tcaattcgag aaattgaatt cctttgacaa 3099181 cgcgtccttc tttgacatca aggcatggga taatccgttt tgtgatcatt tgcgcttcac 3099241 cctttcaagc gcctcactca gcgtaaactg attggtatac agcgcttttc cgatgatcgc 3099301 tccagagacg ccgtccgcct cattgcgggc gagagcttcg agatccgcga cggagctgac 3099361 tccgccggaa gcgatcaccg atttccccgt ttccttagca agctcgaccg tgcttttaac 3099421 attggggcct gacagcattc catctgtcgc gatgtcagta aaaataaaga cttccgcacc 3099481 ttcattggct agctctttgc ccagttcagt tgccttaagg gttgatgttt caagccatcc 3099541 ctctgttgaa acaaaaccgt ttctcgcatc cagtccgatt gcaattttct cgccatattg 3099601 tttcagcatt tttttgacaa acggagggtt agaaactgct gagcttccca ggatcacccg 3099661 ctcgactcct gctgataaat attcatagac gtcattttca gaacggatcc caccgccgat 3099721 ttcgactttc aggttcagct tttgcgcaat ctcaatcaca tggcggtcat tcactctttt 3099781 cccttctttg gccccgtcga gatcaacgag atggatccat tcggcaccct ctttctcaaa 3099841 taactcagcc atgtcgtacg gtgaatcgcc atatatcgtt tccttattat aatccccttg 3099901 aacaaggcga acacatttgc cgtttctcat atcaattgcc ggatataatg taaaagcact 3099961 cattttttca ccttctgttc tgctgccatt ttcgtaaatt gggttaaaat agacattccg 3100021 accgtgctgc ttttttccgg atgaaattgg gcgccgaaga cgtttctttt tccgactaca 3100081 gcaggcactc gtacaccata atcggcgctt gccagaagcg cgttctcctc catcccgtca 3100141 atgtaatagg aatgaacgaa gtaagcgtag ccttgttctg ttttagtcag cagcggagat 3100201 tcattatgaa aagaaagacg attccagccc atatgcggaa ccttcagctt gtttcctttt 3100261 tcatcttctg ctttcagcct gactgctttt ccttttaaca gcccgagtcc tgaagcggtg 3100321 ccgttttctt cgctttcttc aaataaaagc tgcatgccga ggcagatccc gagaagcagc 3100381 cttccctctg agaccatatc gtgaatcaat tgatcaagct tcgtgtagcc caaattgtcc 3100441 atcgcgtctc caaatgaacc gactcccggc aaaatgaaag catcagcttc tttcagctcc 3100501 tccggctttt cagaaacaaa atacggcacg ccgacacgtt caagcgcctt tgagacactg 3100561 tataaattcc ccattccgta atctatcacg ccgatcattt acagcatccc tttcgttgac 3100621 ggtattcctt taactcgcgg atcgatcgtt gtcgcttcat caagcgcacg tcccagtgct 3100681 ttaaaaacgg cttcaatcat gtggtgggta tttgttccat aatgaacgat gacgtgcagg 3100741 ttcattcgag cttcgagcgc cagcttccac aaaaattcat gtacaagctc cgtatcgaaa 3100801 gttccgactt tagcagccgg gaaatcagcg cgcatttcta agtgcggccg gttgcttaaa 3100861 tcaatcacaa cttgagcaag tgcctcatcc atcggcacaa acgccgatcc gtagcgtttg 3100921 attccttttt tatcgcccaa cgcttcgagc agcgcctgcc ctaagcagat gccgatatct 3100981 tcagtcgtgt ggtgatcatc tatatcaaca tcgccttttg cgttaatgga aagatcaaat 3101041 tggccgtgtt tcgtgaataa atccaacata tgtgtcataa acggcacatc tgttttaata 3101101 tccgcttgtc ctccgccgtc tattgtaaat gccagctcaa tatctgtttc gtttgttttc 3101161 ctgacgcgtt ccgcttttct catttagaaa tcctccgttc tctcgcttca attgatctgg 3101221 catgggcttc taacccttcc agtctggcaa aagccgcgat gctttcggca tgttcttcaa 3101281 aggctgattg actgtaagaa ataatgctcg atttcttttg aaaatcagtt acgtttaatg 3101341 gacttgaaaa tctggctgtt ccgtttgtcg gaagcacatg gttcggtccg gcaaaataat 3101401 caccgacagg ctcagggctg tatctgccta agaaaattgc acccgcatgt ttgatactgc 3101461 caagcaaagc ttccggagac tgtgttatga tttctaaatg ctctggcgcg agtgtattga 3101521 cagtctcaat cgcttctacc attgtttccg ccacatatat acaaccgtaa tctctcactg 3101581 aagcttccgc tatttctctt cgcggcaagg tttccagctg cttattcacc tcggctgaaa 3101641 ccgtctcggc cagcgccatg gaatctgtga caaacacaca tgagctaagc ttatcgtgtt 3101701 ccgcctgtga cagcagatcg gctgcaattt cgctcggaat cgctgtttca tcagccagca 3101761 cgacgatttc actcggtccg gcaatcatat cgatatcgac atcgccgaac acttctcgtt 3101821 tggcaagcgc gacataaatg ttgcccggac ccgtgatttt atccaccggc tcaatggttt 3101881 ctgttccgta tgctaacgcc gcaatcgcct gagcgccgcc cattttgtaa atgtctttta 3101941 tgcccagctc ggctgcagca accaaaactc caggagacag cagaccgtct tttcccggag 3102001 gcgtgacgag aacgattctt tcaacgcccg ctacgagcgc cggaatcaca ttcatcaaaa 3102061 cagatgaagg atatgcggcc gttccccccg gcacatatac accggcggaa tccagcgccg 3102121 tcactttctg ccccagcatt gtgccgtcct ttctgtgata aaaccaggag gattgcagct 3102181 gtctttcgtg atattcccta atattttcga ttgcctgcct aatcacctga agaagacgtg 3102241 aatccagtga ggtgtatgcc tcctcaaatt cttcttttgt gaccagcggg ctgtctattt 3102301 cgatgcagtc aaatttcgcc gtgtagctgc gaaccgcctg atcaccgttt gctttaacat 3102361 cttcaataat ggaccggacc gtctttcttt gctcttccgt tccggcatcg atggaacgct 3102421 tgagagaaag ccgttccgct ccgctgatgg ttttgatctt cattttgccg tctctccttc 3102481 cacaacgaga gataggcggg atgccatttc gtcaatcaca tcgtctttca tgcgatagct 3102541 taccgggttg acaataaagc gagaggtaat gtcacaaatg tgctccgttt caacaagccc 3102601 attttctttc agcgtctgtc ctgtggaaac aatgtccact atccgatctg caagcccaat 3102661 gagcggagcc agttcaattg aaccgttgag cttaataatc tcgacttgtt ctccctgctc 3102721 tctgaaataa ctggaagcca cattcggata ctttgtcgcg attcttggcg ctactccgct 3102781 ccagtctgta ttcggaagtc cggcgacagc taagtggcat ttgctgatgt ttaaatccag 3102841 tacctcatac acatcgcgtt cctcctccag catgacatcc ttgcccgcaa ttccgacgtc 3102901 tgccacgcca tgctccacat acgtggttac gtccatcggc ttcgctaata taaaccgaag 3102961 attttcctcc ggcacatcga tgatcagttt tctcgaatct tcaaactcct cagggagcct 3103021 gtagcctgcc tgcctcagca gccctgccgc ttcttcaaat atccggccct ttggcatcgc 3103081 cattgtgagt aacttaccca ttttgctctt cctttctggc accgataaaa taagtgacgt 3103141 ttgcaaaaga ttttgtcatc tggtcgatat tttctattcc cgataaatct tgaagaacca 3103201 ctttgttccc tttcatgcgt tcttcattcg cataagcgat ggcttgcgcc cgctgctctt 3103261 tgctgaaaat aacagcgtct atttcacaag gttcgtcctt catatgaagg gcttcaatca 3103321 gccggtcgat ccgaagcccg aagcctgttg ccggtgcagg tgaatcaaaa tggcccagca 3103381 gcttgttgta acggccgccg cttccaatga caaaaccgac attctcggcg tacacttcaa 3103441 ataaaatccc tgtgtaatag ctcatgtggc tgaccatatt cagatccagg cggacatttt 3103501 ccgtacatcc gtaatcctca agaatgtccc acagcgcctt cagctcatca accacgcttt 3103561 ttccttgcgc agaatcgacg atttcctcgg cacgtccgca tacttctata ccgccccgca 3103621 gttcaaggag ctcaagcagc ctgcttttat caatggagga aagcgggaga gacttgacat 3103681 gctctctgta gccgacgtag ttcttttcat ataagaacct ccgcagcaca tcagctcgtt 3103741 caacgtttcc gagcacctca acaaacaaag catccgcaat gccggcatgg ccaattgcaa 3103801 ttttaaagga tgccagccca gcgtttttta atgccccgac gactaaagca atgacctccg 3103861 catccgcgct cgtcgtgccg tcaccgatta actccactcc gacctgctcg aactcagccg 3103921 gacgtccgcc ttcacgctcc tgagccctga atacatttgc cgcatagccg actcttagcg 3103981 gatgaccgtg tttcagaagc ttcgatgccg ccacccttgc aatcggcccc gtcatatccg 3104041 ggcgaagcac caatgtcttg ccgtcctgat caagtagctt aaacagctgc tgctcttcaa 3104101 ttgctgactg gacgccaacg gtatcgtaaa actccagtgt cggcgtttcc ataaattgat 3104161 atccccattt atcaatcaaa tcggttaacg atcgtctcac cttttttttc gtttcgtata 3104221 aaccgggcag tgtatctctc atgccgtgcg gtttttcaaa cataaacatc aacccgagca 3104281 cctccgctgt tatcttatga aggaaaattc cgaatccttt agttcgctaa tatgataata 3104341 tgttagcaga tgaaagaatg aaaatcaacg cttaacttca gtaaggatat ttttagttca 3104401 aatatccttc tcctcattat gaaaaaatca tgaataatgt attaaaggta cgtaatatct 3104461 caaattcttt atgtttggca tgctataata caaatcaaat agagaacaag gagataaaga 3104521 tgaaaacact gcgaactcta tgtgtcctga tgattctttc aggcgttatt tttttcggac 3104581 ttaaaataga tgcaaaagat atagatattc cttttttgaa cagccttaaa aaagtggttt 3104641 ctgatagcga tacagactca gctgcgaata gcaaaaagga gctgaaggga agcgcaaaac 3104701 cgctggatgt catcctttac aatcaaatgg acgcaccccg gctctataac ggctgtgaag 3104761 taacaagcct tgcgatggtg ctgaattatg cgggatacga cgtgacaaaa aataccctgg 3104821 caaatcaggt tgccacagtg cctttgacat acagcagcgg attaaagggt gatccgaatg 3104881 acggatttgt cggggatatg gcgaatggcc ctggtctcgg tgtctaccat cgaccgatct 3104941 atcagctggc gaaaacctat gcgggagaca aagtgtctga tctgactgga aaaagtattt 3105001 ccgctgttta tcagcagctt gaaaaaggca atccagtttg ggttattacg acagccaact 3105061 ttacgccagt tgacaacatg cagacatgga aaacgccaaa cggaacgata gaaattacgt 3105121 acagcgaaca cagcgtcgcc gttacgggat atgatgataa atatgtgtat ctcaatgatc 3105181 cgtatggcta taaaaacaga aaaaccgata gaacaagctt tgaaaaagcg tggaaacaaa 3105241 tgggcagcca ggccgtggtt attcaaaagt aaacacctga agcctcacta tgctctattc 3105301 tgagcaaata cgacaatatt catgcttttt gtatcaatcg gtaagatcga ttcattttcc 3105361 atttttcacc caaaattgtc tttactttca ggctgtctgt ttttatgatt aaagcagatt 3105421 cagccttgcc ccgatctatg cgagagaagc cggtgcaagt cgctgacgct tctcttgcaa 3105481 aaaatgaaag atatccgggg aggatttatc attgaaaaaa atcgtgtcta tcctatttat 3105541 gttcggtttg gttatgggtt tcagccagtt tcagccatca accgtttttg cagctgacaa 3105601 agtggtgcac gaaacaatta tcgtaccaaa aaatacaaca tatgacggga aaggacagcg 3105661 gtttgtggca gggaaagaat taggtgacgg aagccagtca gaaaaccaag accctgtttt 3105721 tcgtgtggag gatggagcaa ccctgaaaaa tgtggtgctt ggtgcacctg cagctgatgg 3105781 cgtgcacact tatggaaacg ttaacattca gaatgtgaaa tgggaagatg ttggtgagga 3105841 tgcgttaacg gtgaagaagg aaggaaaagt gacgatcgac ggcggttctg ctcaaaaagc 3105901 gtcagataag atattccaaa tcaataaagc cagtaccttc acagtgaaaa atttcacggc 3105961 ggataatggc gggaagttca ttagacagct tggtggttca accttccacg ttgatgtgat 3106021 catcgacaag tgcaccatca caaacatgaa ggaagcgata ttccggacgg acagcaaaac 3106081 aagcacggtc agaatgacaa atacacgcta ctctaatgtc ggtcaaaaat ggattggtgt 3106141 tcagcatatt tacgaaaaca acaacactca attttaacaa aaaaagtccg ctgatgttat 3106201 tcagcggact ttttcaatct ttcttgcatt tcttccttcg tatagatgat cctcatcgga 3106261 tttccgccga caaatgcccc gtcaggcaca tccttatgga caagcgttcc ggcggacaca 3106321 actgcgccat ctcctatttt caccccgggc agaatggtcg tgttggcacc aatcatcact 3106381 tcgtccccga tcagaacttt gccgatccgg tattcgtgaa tcaaatactc atgggccaga 3106441 atggtcgtat tgtacccgat gattgtattt gttccgactg agatcttttc cggaaacatg 3106501 atatctggca tcaccatgag ggcaaaggat gtctgttttc caaccttcat ccgcagaaat 3106561 gtgcggtaca gccagttttt catccctata aacggcgtat atctcgcaat ttgaatgaca 3106621 atgaaatttt tgacgacctt taaaaaaggt accgtttgat agacatgcca cagtgagttg 3106681 gcccccgaga ccggatgacg atctgttttt ctcacagatt acttcactcc aacgatttgt 3106741 aatagatcac tcattttctc aagcataaaa tccggctcat gcttcgccag catttccggc 3106801 cctttaatcg tccatgcgac tcctgccgtt tttgtaccgg cgtttttccc tgccagcaca 3106861 tcatggtaat tatcaccgac cataatggct tccgccggct cgcttcctag ctgtttcagc 3106921 gctaacagca caggctcggg atcaggcttt gcattcgtca catcatcaag ggtgacaact 3106981 gtttcaaaga attcgccgat tcccgtgagc ttgaggccca tattgacagt atctcttaat 3107041 tttgttgtca caattcctaa tgtaaagccg gcttttttta atgcatccag ggtctcatat 3107101 accgtttcat attcagtgac gagtgaatca tgcatgtcat gattgtacgc tctgtacata 3107161 gcgatcatat cctcgcattt atcagggtcc atcgaagaga acgtatcaaa aagagacggc 3107221 ccgataaatg caaggacatc ttctcgttta tacttgctcg gataataatg ctccagtgta 3107281 tgcaaaaagg acgcgataat taattcattc gtattaataa gcgttccgtc taaatcaaac 3107341 agaatcgtcg ttacttgttt gtcactcata ttgcttcctt tccaaccgct gagggtttcc 3107401 attttttcca cgtgtgcgca atagccattg tcagcagaac tgctgtggtg acacgaatca 3107461 aaagaagcgg ccagaccggt atgccaagcg gaataaagac aagtgtatct tccacgaccg 3107521 cgtggcaggc aacgagaaat ataaatgcca atgtcatgtc ccgcttgctc acgccgtcat 3107581 cctcgacagc tttgatcatg acacccgctc cgtaggccag accaatcgtc agtcccgtca 3107641 ccatcgtcat agacgtattt ttattcatgc caagcagctg cgtaaacggc gacagccacc 3107701 tggaaaaccg ataaagccag cctaaatctc ttaaaaactg gatgataatc atcagcggga 3107761 tcactattgc cgccagctgc aaaacaccaa gtccggcttt cgttaatgct tctgccaaca 3107821 ttcctagcca gctgtctggc gccgcgctct tcgcagcgat aaaaccgtac tgcgccgttt 3107881 cctttccgcc atgccaaatg aggttgatga cgatggctga cacagcggcc aaaccgatgc 3107941 gcacggccaa tatgacgcca attctgatac caacctttgc ggcaactgtc gattcgataa 3108001 tcaagttatg acagaaagaa agcataacag ctaaaataaa gacttctttc acagataaat 3108061 ccaatgttaa aatcccggca attcccgcat acagattcag catatttccc agtacaagcg 3108121 gaatggccgc ttcaccagaa agcccgaaga gacccattac cggtgtgatc agccgtacaa 3108181 gccaatccat gacaggggta tgctggagca aagtgaccaa tagcgttacc gggaaaatca 3108241 ctttacccag cgtccatgtt gtttgaaaac ctgctgcaag accggccaga aagatcttct 3108301 tcatccctca tccccctttg ttgacgtcta ctccgcgtac cgctccttcg agtatccctt 3108361 gacgcgtctg aagatgatgg ctgccacagc caaaacaatc aatacgattg aaatcacctg 3108421 agcgatgcga agtgaatcag tcagcattaa gctgtcagtc cgcattcctt caataaagta 3108481 tcttccgatt gaataccaaa tgatatagat caagaacatc tcgcctctac gcaaattcgc 3108541 tctgcgcagc agcagtaaaa caatgacgcc gacaaagctc catagtgatt catataaaaa 3108601 agtaggatga taatattgcc cattgatata catttgattg atgataaatt caggcaggtg 3108661 caggttttct aaaaaggctc tgctgacagc ctcgccgtgc gcttcctgat tcatgaagtt 3108721 cccccagcgg ccgatcgcct ggccgagcaa aatgctgggc gcggcaatat ccgcaagctt 3108781 ccagaacgaa aggtttttca ctctcgaaaa cacataaccc gttaaaatgg cgccgattaa 3108841 tccgccatga atggcaatgc cgcccttcca aatcttaatg atttctcccg gatgtgccgc 3108901 ataatagtcc cattcaaagg caacataata aattcgtgcg caaataatcg caattggaat 3108961 ggcaaacagg acaagatcaa taaacgtatc tttctgcagc ccccgttttt cactttccct 3109021 catcgctatc cacagcccga gcaaagcgcc gagaccgata atgattccgt accagtggac 3109081 ggctaacggc cccagctgaa atgctatcgg attgagtggt tctatcgctt cattcattta 3109141 acgccaactc ctattcttct tgttcaccgt cttcaatgac gtccgccagc ttgttggtaa 3109201 attgttcagc ggcattcagc cccatccgct tcaatctgaa gttcattgct gccacttcga 3109261 tgatgactgc aagatttcgg cctgggcgga cgggaatcgt cagttttgta atttctgtat 3109321 caatgatttt catggtctct tcctcaagtc cgagccggtc gtattgcttg ccctgctccc 3109381 agagttcaag attcatgaca atcgtgattc gtttattgct tctgaccgcg ccagcgccaa 3109441 atagcgtcat cacattgata atgccaaggc ccctgatctc aagaaggtgc tcaattaatt 3109501 ccggagcgtt tcccacaaga gtatcctgat cctcctgccg tatttcaacg caatcatcgg 3109561 caacaaggcg atgccctctt ttcacaagct ctagcgctgt ttcgcttttt ccgacgccgc 3109621 tttttcctgt gatcagcacg ccgacaccat atatatcgac aagaacgcca tgaattgctg 3109681 tggtaggcgc cagcctgctc tcaaggaagt tggttaaacg gcttgacagt cttgtcgttt 3109741 tcagcggcga tctgaggaca ggcaccccat ttttctcgga ggcgtcaatc agctcctgcg 3109801 ggatgggcat atctctagaa agaataatag ctggtgttac atcagtgcac agagaatcca 3109861 ttcgctgctt tttctcctct tcaggaagct gttcaaagaa agaaagctct gtttttccga 3109921 gaagctgcac gcgctccctc gggtaatatg taaaatatcc ggcaatttca atacctggtc 3109981 ttgataggtc actcattgta atcgggcggt taattccttc ttctccgctg attaattcca 3110041 aattgaactg ttccattacg tcttttgtgc gaacctttgc cacgatatgt tcctcctgtt 3110101 ccgggctgcc ccgagcttgc tcacaatact ttcattttat cactttcggg cttgaaccta 3110161 aaacagattt tataaaaggg gggaaaacac ctcagctggt ctagatcact agtctgaaaa 3110221 agagtaaaat aaaggtattc aaattccaga aaggcggatc atctatggca gagagtcttc 3110281 ttatcaaaga cattgcgatc gtgacagaaa atgaagtaat caaaaacggc tatgtcggaa 3110341 tcaatgacgg aaaaatcagc acagtttcaa cagaacggcc caaggagcca tattcaaaag 3110401 agattcaagc acctgcggat tccgttttgc ttcccggcat gattgacatt catatccacg 3110461 gcggctatgg cgcagataca atggatgcta gcttttccac gctcgacatc atgtcgtcaa 3110521 gactgcccga agaaggcacg acgagctttt tagccacaac gattacccaa gagcatggga 3110581 acatttctca agctttggtg aacgcaagag agtggaaagc ggctgaagag tcctctttat 3110641 taggtgcaga actgctcggc attcatttag agggcccctt tgtttcgcct aaaagagccg 3110701 gagcgcagcc aaaggagtgg attaggcctt cggatgttga gcttttcaaa aagtggcagc 3110761 aggaggcggg cggactgatc aaaattgtta cacttgcgcc ggaggaggat cagcattttg 3110821 aactgatccg ccatttgaaa gacgaatcga ttatcgcatc catggggcac acggatgccg 3110881 attccgcatt gctgtcggat gccgcaaaag caggggcgag ccatatgact catctgtaca 3110941 acgcgatgag cccgtttcat caccgagagc ccggagtgat cggaacggcg ctggcccatg 3111001 atgggtttgt gacagagctt atcgccgatg gcattcactc ccatccttta gctgcaaagc 3111061 ttgctttttt ggcgaaaggc agcagcaagc tcattttaat taccgattcc atgagggcaa 3111121 aaggactgaa agacggcgta tatgagttcg gcggccaaag tgtgacggta agaggacgaa 3111181 cagcacttct ttcagacgga acccttgccg gttcgatcct caaaatgaac gaaggcgcac 3111241 ggcatatgcg tgagtttaca aattgctctt ggacggatat agctaatata acttctgaaa 3111301 acgcggccaa acagctgggc atctttgacc gaaaaggcag tgtgactgtg ggaaaagatg 3111361 cagatttggt gattgtcagc agtgattgcg aggtgattct caccatttgc cgcggaaaca 3111421 ttgcatttat atccaaggag gctgaccaga tatgaaagta atggaatgtc aaacgtatga 3111481 agagctaagc caaatagcag ccagaataac ggcagataca atcaaagaaa aacctgatgc 3111541 tgttctcggt ttagcgacgg gcggcacacc ggaaggcacg tatcgccagc tgatccgcct 3111601 gcaccaaact gagaatctct catttcaaaa catcactaca gttaatttgg atgagtacgc 3111661 cggactttca agcgatgacc cgaacagcta tcacttctat atgaacgacc gtttttttca 3111721 gcatatcgac agcaagccta gccggcattt tattccgaat ggaaatgcag acgatttgga 3111781 ggccgaatgc agacggtatg aacagctagt cgattccctc ggcgacactg acattcagct 3111841 tctcggcatc ggccgaaacg gacacatcgg ctttaacgaa ccgggaacgt ctttcaagtc 3111901 gcgaactcat gttgtgacat taaatgagca aacccgccaa gcgaatgcca gatattttcc 3111961 ctccatagac agcgtgccga aaaaagcact gacaatggga attcaaacga tactctcaag 3112021 caagcgcatt ctgctgctta tttctggaaa aagcaaagcg gaagctgttc gtaagctgtt 3112081 agaaggaaac ataagcgaag attttcccgc atctgctttg cacctgcatt ccgatgttac 3112141 ggttttgatt gatcgtgaag ccgcgtcatt aagaccttga aaggaacatg ctgacttatg 3112201 aatatcaata aacaatcgcc tattccgatt tactatcaga ttatggagca attaaaaacc 3112261 caaattaaga acggagagct gcagccggat atgcctcttc cttctgagcg cgaatatgcc 3112321 gaacaattcg ggatcagccg gatgacagtt cgccaggcgc tttctaattt agttaatgaa 3112381 ggcttgctct atcgcctgaa agggcggggc acctttgtca gcaagccaaa aatggaacaa 3112441 gcacttcaag ggctgacaag ctttaccgag gatatgaaaa gccgcgggat gacaccgggc 3112501 agcaggctca ttgattatca gcttattgat tcaactgagg agctcgcggc tatattaggc 3112561 tgcgggcacc cctcctctat ccataaaatc actcgggtgc ggctggcaaa tgatattccg 3112621 atggcgattg agtcctcaca tattccgttt gagcttgcgg gtgaattgaa cgaatcgcat 3112681 tttcagtcgt cgatctatga tcatattgaa aggtacaaca gcataccgat ttcccgtgca 3112741 aaacaggagc ttgagccaag cgctgccacc acggaagaag cgaatattct tggtattcaa 3112801 aagggagcgc ctgtcctatt aattaaacga acaacatatc tgcagaacgg aactgctttt 3112861 gagcatgcaa aatccgtata cagaggcgac cgttatacat ttgtccacta tatggatcgt 3112921 ctttcataaa aaaagcctcc aacccttttt aaggattgga gacatggcga aaatcaaact 3112981 ggtctggtgc cggacgatat gtttcttttt tcgtcttgaa cttccagatc ggtgatttcg 3113041 ttttgccgtt aaaactgtct tccactataa tgtaccaata ataaacagac tgcggttcaa 3113101 gatgatccca gcggaattca gctgtgtccc cgctcttcac ttgctcccgt tttccgagct 3113161 cttcattggt atatacgtta cattcaaaat aatcggtttc cacctttttg attcttggct 3113221 tcaaatcaag cgaaagggaa aattcatcct tgttgccata ggtatccgta tcatagtagt 3113281 tcttatcctt tacatacgga gagtacgtcg atacgtgcac catgtcattg gcttggtcaa 3113341 attgaagcaa acgcaaatac ccttggccgc cttctggccc gccctgataa tcggccagca 3113401 tttgatgcac aagacgatcc ggtttcccat caccatcatc atccagctca tctgtttttc 3113461 tcatcgcact atgataatgc ccgctcaaca ccatcacgac attcgggttc ggctttacga 3113521 tttctttgaa tattttctct ccgattgggc ttctgtttcc gctgaccagc aaatactcat 3113581 gaaaagctaa aatggccatc cggtcaggat gcttcttcag cacctgattc atccacgcga 3113641 tgtcttcatc cgtaatgccc catcccatgt acagcatgat ataatcattg ccgttgctag 3113701 aaatcaggtc ataatgtccg cggttatttt tataggaacc gccataatga aattttttat 3113761 caaaacgatc gctgccaaaa tatttgccaa acgccctgta ggagccgtcc ttatgtccga 3113821 catcgtgatt gccggccagc acgccgtaag gaattccgct cttatccaga acggacattg 3113881 accgatcagc gtttttccac tgtctgatat cggcggaatc atctacaata tcacccgtgt 3113941 ggaacacata tttgatattg agctgctttt gattatcttt tatccattcg gtctgtttat 3114001 caaaaatatg cggatagctt tcggcgtaat actgtgtatc agacatccag acaaatgtgt 3114061 acatatcctt cgcaggagga atttcatcct gtacaatcac attcattttc gactcccgta 3114121 caaaatcggc ggcaatcaca gacgctttca gcgtaaacgg tttgtcatcc ttcgcgacga 3114181 agctgtcaac aggctgccat tcgtttgtcc gataattcca agcatacatc gtcacctttc 3114241 tccccggcaa agaactgccc ttccagactg attctgccag atcattctca tcaattgatg 3114301 gatcaaccgt cacttcaaag cgatgataag ggaaaagctc tttgttttct gtcgatactg 3114361 tttttccatc agcagctgat acccgctcca attctttatt cgtaaatggg gtctcccttt 3114421 ccggcacaaa gcttttcggc ggttcagtca gtgacgcgtg cttaaatatt ttcacatgat 3114481 tgcgcgctgt atattgaaat cccctataaa aaccaacatc catggcatca ttcgtcggat 3114541 ctttcacccg tacagaaagc ttggccttat gcgtgtcggc ttcgctgtct ataacctccg 3114601 gctggtccgg atgctctcgt tcggttttaa atatcctctc aatcactgtt ttattgcccg 3114661 cgagatccgt tgctgtcact tttagagaat gttttcccgg caaaaggtca gaagatgacg 3114721 tatgatatgg gagtgtaatg ctttctccat ctaacgacgc ctccgcttcc tcaattctgc 3114781 tccatttatc atacatatcc gcctgcagga taaggtttcc tttatacgtt tgcccctcgg 3114841 tgatattcgg ctcaatgtga ggtcctgaat tatctacccg tacaaccagg ctgacatttt 3114901 ccttcccgtc gcttgcttga atatggtgag cgccttcaga aagctttgat gtatcccact 3114961 ccagcagctg tgatgtaaat agtccgtcag gcagattgaa ctgaaattgc cagcttttat 3115021 tcgagcgctg attatcgcca ataaagagtt ccttctcagg agacaccctc tgatctctga 3115081 tcaccgttcc atccgataac accaatcggg cgtttttgac taagaagtca tcacggtttt 3115141 cagccgtatc aaacggagac accttcgaac ctgaacgtat cgtaatacgc tgcagctgct 3115201 tccctttccg aagcagtgtc tctggcaatg gaacagaata ggtgcggtat ttatttgttg 3115261 tatcatcgaa caccttcagc actttgcctt ccatcgttac cgcgttttta aaataaaggt 3115321 tcgttttcct cgtatcgaat gcaaaatata cttctttttc catcgcgggc tctgtcactt 3115381 gttttttccc gtcaatccat agcttaatgc tgtcagctcg cccttctgtc gtggctttga 3115441 gaaattgagt tcccgacagc gtgtctctgt tttcaatatt catccgcaga ccgtgcgcct 3115501 tgcttgtttg tttaatatca atcattttga ccggcgttct cgcttcattg atcccgtccc 3115561 cggccgccac ataatactct agctgatcct tcccgatcaa ttcaggcgaa tacacaatat 3115621 aatggaagag attatcgttg cggtcttttt cagcaagaat tcgcttaaac ggtttgttct 3115681 catccgtccg gtagtaaaag gccactgttt tcactaggct tcggtcccgt atgtcagccc 3115741 gcagctcaat gctttcagca gggcggacag gcttgcggtc agtcaaatcc tcaatgaccg 3115801 gcttttcttt atcgagcttg attttccgtt tctggtcggg cacctgtgcc tgtaatacgg 3115861 ttccgggaga cggattcttt tccccgattg aaatgttcag aagttctgct gttccgttca 3115921 gtggatactt ataaagcact gatgacagcc ggcgcagcgc atgtttccga taatgcgcaa 3115981 ccgaaatgtc ctttcctgta ttcgttgata tcacaacggc ccgcggcctc gtattggcca 3116041 taccctctgt ctcgtctatc accgcaagat tttttccttc ttttagttgt gtctgataat 3116101 aacgattgaa atccgctgac gtcaattctg gatgcccggc aggcttcagc cagacgacaa 3116161 acgtttcgcc ggatggtatc aagatccttt catcaggtct ccaaatcaga tcggagtcag 3116221 gcccttcttt tgggtagcgg taacggatat ggtagtcttt aaaatcaatc gttctgtcag 3116281 tcgtattaaa aatctcaata aattcataac cgtctgcgcg tcctatattc ttcgtatcaa 3116341 ccgccagctc tgtgatcaga agctccggaa tatgggcaag gtcagcctgg tatccttcaa 3116401 gcttcagttt cttcgtctcc gactcaaccc gctgcttccc attcgacatc acaatgtaat 3116461 actcaagctc gctgttccaa atcaaacgtt tcggaatttg tgccaaaaac ttgcggaccg 3116521 ctccgggggt cgggtccatc ggcaccattt tgtagcccag ctcattactt tgtttataaa 3116581 aaagaaaggc ggaaaatgct tgatacgaat tatcgcgaac ttgagcctca atcattagat 3116641 tgcttctcat ttcagctttc acatcaattt gaggaggatt ttcaagcaag ggtatgtaat 3116701 gaggcgtttg aaatagttcc tgctgtacaa caggaaaagc tttcgattca tgatggccgc 3116761 cagacaaaac ggaaagaaaa gacagtaata tagaagcaat aaccgtgtat ttcctcatca 3116821 aagcacctcc cttttcatgt attttgcgtc tgaacaggga agcttatgag ttcatttttg 3116881 tgcataaaga acaaaaaaac gtctgtctct tgaaaattcc actattaccc agtaaactaa 3116941 ggatagttaa ccagttaaca attaaatcag agaggcaaat tgatggacaa cagcattcat 3117001 gatgaattat ttcaagctat acaacaattc gcattaaaaa gggataaacg cgtctggcaa 3117061 aaggtgcaga taccatccat tggcatatcc tcacaacatc acgatcacct caaaaaagac 3117121 tggactttga cccagcttca cattgtttcc tgcatacata ccagccaaaa tgtgaacaac 3117181 agcttcttag catcccgttt acacatctca aaagccgctg tttcaaaagc ggttcatgct 3117241 ttgttgaaac acaatatcat tacagtgaca aaaaagcctg gcaacaaaaa agaaattttt 3117301 tatacgctaa ctgatagcgg cagaaaattg gcggcattac atgaacagct tcatgagaaa 3117361 gcaaaggagc aatataaaca gcttttcaat gaattttcaa ttgatgattt aaaaacagtg 3117421 actgcgtttt tcaacttgtg gatcaaatat atgtaaaaag agtctcaccc gcatgggaga 3117481 gacctttgga attctattat gccccgtcaa acgcaacgag aagtgaaaca ggtccgcgtg 3117541 tatacagacc ggactcagca taacaaaaat cttcctctaa tctgatattc cgcatcttat 3117601 ccagcacaat attagctaca atttcgattt cgtttttggc aaaagctgct cctacacagt 3117661 tatgaatgcc ggatccgaaa gcgagatgcc gggcggcgcc gctaaaagcg ctcttgatac 3117721 caagatcttc ccgatgaata ttaaacacgt caggctgttc aaatgcttca gggtcccggt 3117781 tagccgcacc gatcatacaa aaaacaatcg tatctttttt gatttccata ccgccgacca 3117841 ctgtatcttg ggacagctgc cgcggaatca gctgaaccgg cggtttataa cgcaatgtct 3117901 ccgcaatggc tctcggaact aacgaacggt cagccaaaac atcattcatc tgctcaggat 3117961 tgttgagcaa atggtagatc atcagtgcca gcgtcttatc agccggttcc gttgcggcta 3118021 acagcacatt aagaatcagt gcgagtatat ccttgtccga cagcgccatg ccttcatatt 3118081 cagaagtaca taggatcgaa attaaatctg atcccggatt gacgcgacgt tctttaatga 3118141 ccggcatcaa gtattgggaa agctgttcgc tgcaccataa cgaatgtgcc cgcgcttcag 3118201 gagattgaga gatactcgtg ataaaatcgg caactccgct gtgccactca gagatttttt 3118261 catggtctct tttatccagc ccgagcatgt ccatcgtgac gcacaccgca aacgtctttc 3118321 caaaatcatt gacgagatca cttttccctc tttcaagata aggcgctaac aagttttctg 3118381 cattttgttt aatcaatgga gacagatgat ccagtgcgtc accgataaag cttctcacta 3118441 caattcttct tttggcagag tgttcttttc catgcatttg ggccagcaca gggcctcgca 3118501 tgactggttc ggcacgctca acaagtgatt tcgtcgtgaa gatatccgga tgctgaagga 3118561 tatagcggac atcatgatag cggctgataa aataactgtc tatcgactct tcataatgaa 3118621 ccggatcttc ctcccgcagt tgtgaaaaat aagcatatgg attgttttga aattgatcag 3118681 aaagcacact aaacaattta atcgattggc tcatgtttta ctccccctat catccttcag 3118741 atgtgatccg tttctcagaa agcatctgcg ccatttcctg tacaatgaga tacccttgat 3118801 tcggccgcat acaaatagaa aattcatggt tactgatctt ctcacccagc ttccacggac 3118861 gatgataagc aaggagtgtc tcttccacct ctaaaatatc cggagctccg ataaaaaacg 3118921 gcagctcagc tatgacatat tccacagcca aattcagcat atcctcactg acttcttcca 3118981 tcatcaaact gacgccccgc gcacgcccga ttatcgcttc acgagacatg tccaaacaag 3119041 catgtcgaaa atgaggctgc tcaaaaaatg catgttcaac ttcttgtctc aacagctggt 3119101 aggctttgtt atctataaaa tcagaaaatg tatgaatcgc cttcggatcc ccgccatgag 3119161 ccacaagggc tctttctgca aatctcctgt ttcgtgatac ctctttcctt acttttcgtt 3119221 cagcctttcc tctcggagtt ccaagcgctt ctagaagatt agccgcctca tgccctgcaa 3119281 gtaaaactga aacgctttta aattgagctt tcgcccatcc aattaatctg taaatataat 3119341 cctctgaaaa cctgctgtta aatgggctga tccccaccaa aacatgcctg cgccgttcaa 3119401 atatttctct gcagttttct gttaatgcct cagcaataaa atgcacagac cttctttccg 3119461 ttaccattcc ggtcatctca ttcaccccta aaacttatcc cgctttaagt catcaccctc 3119521 aaatacaaga tggaatagct agaacaactg aacaagacga atggcaggca tcacttaaag 3119581 tttccaaatg ttttttaaga ttttaataat cattttcaat acccatatca tgataaatgt 3119641 ttactagtaa acattagtca ttttatccct tttccttcca aacgtcaata tgatctgtgc 3119701 ccaaatattt gaaaataaat gtaaacatca cattttccac acacttttta cacgcatatt 3119761 cagcatgaca tatcaacaaa tagtctaaac accaacaatt gacaacgaaa acaagaaaag 3119821 ataaaataaa attgttcacc agtaaacgat ttgttttatt gtttcatcgt aaactattat 3119881 tcctaagaaa gaaggtagcc tatgtctgat ttgacaaaac agatgatata cgacatatac 3119941 gtgagactgc tgcaccttaa tgaacaaaaa gcgaacactt cacttcagca attttttaag 3120001 gaggccgcag aagaggatgt agctgaaatt cccaaaaata tgacaagcat tcacgtcatt 3120061 gactgcatcg gccagcatga acccattaat aatgccggaa ttgccagaaa aatgaactta 3120121 tcgaaagcga atgtaacgaa aatcagcaca aaactgatca aggaagaatt cattaacagc 3120181 tatcagctga cagataacaa aaaagaagtt tattttaaat taacccgtaa aggcagacgg 3120241 attttcgact tacatgagaa actgcataaa aaaaaggagc tggcttttta ccaattcctc 3120301 gattcatttt cacaagaaga acaaaaggct gtattgaagt ttctagagca gttgacgtca 3120361 acacttgaag cagaacaaac cgatgggact ccagacaaac ctgtaaagta aacaaaaagg 3120421 cggtgtacac tttggctcat acaaaatcaa aggcagtatt gatcttatac actgtttgct 3120481 tcagtgcatt ttttgcatct ttaagccaga acatttattc acctattctt ccgatcatta 3120541 aagaatcatt ccatgtttcc acagctatgg tgaacctgtc agtctcagtt tttatgattg 3120601 tgacagcaat aatgcaaatt atattaggag cgatcattga ttttaaaggc gctcggatcg 3120661 tcttgattac cggtattctg gcaacggcag cagccagcat cggctgtgcg gtgactactg 3120721 actttacctt gtttctgata ttcagaatga tacaggcagc cggttccgca gcactgcctc 3120781 ttattgctgc cacaacgatc ggacagctgt ttacaggaaa tgaacgcggg agtgcaatgg 3120841 gaacgtatca aatgctcctg tctgtcgcac cggctattgc tccagttcta ggaggattca 3120901 taggcggagc agccggatac gaagggattt tttggatact tgcggccatc tctatcgttt 3120961 tgctggtgac aaacagcatc acctttccta aagattctcc aactgaatct atgcagcaag 3121021 ccaaaggcaa tgtgttcgct cattataaat caatatttac aaatcgaaca gggaacgtca 3121081 ttttgacttt aagttttgtt ctctttttca tttattttgc agtaattgtc tacctcccaa 3121141 tattgctgac agagcattac catatagatg tgggtatagc aggactgtta tatttgccgc 3121201 tggcgctgag cacgattgca ggtacgtttc tgtttaaaag aatacaggca aaaatcgggc 3121261 tgcacacctt gtttatcgga agcaatgtga ttgccgcctg cagcatcatt ttatttgctg 3121321 ttacacattc cgtttctctc gttctcatgg ctctgacgct ggcactgttt ggcatctcga 3121381 tgggggttat tcctcccttg tactctacaa tgattactaa tgaatttgag cacaacagag 3121441 ggagtgcaat cggaatgttt aactttatcc gatatacagg catggcagca ggtccgatgg 3121501 tatctgccta cttgctcaca atgatgccgt ctgccatgtc ctttagcctc ctaggccttg 3121561 gatttgccgc attgagcttt tgccttcttc cgccaatgtt ttcgccgcag aagcgcacga 3121621 aacaaaaaaa gcaccacatg taaaaaagct gcctttgcgg gcagcttttt ttattttttt 3121681 ctaagcggct ctaaaatgcc tttttgaatc agcaaatgga agaccgacag gataacggat 3121741 gcccatatcg ctgtgccgaa gccgtcgatt tgaaagctgt cacccataat ggacgcggtc 3121801 atcataagcg tgatggcgtt aatcacaaac aagaagagtc caagcgtcac catggtgacc 3121861 ggcagtgtaa atataattaa aagcggttta atcagcacgt ttaagatcga taaaatgagg 3121921 ctggcgataa tcgctgcccc aatgctgctg atatggatgg agtcaatata tccatcaatg 3121981 acgattaata acaatgcatt gactaaaatg ctgactgccc attttaccat gtcatttcat 3122041 atccctttct gacgggacga taaaaatcca aatgatataa atgagcaaaa ccggcaagac 3122101 acttgtcata atggctaaga tgacagttat gactctgagg agtgatgcgt cccaattgaa 3122161 atattccgcg agacctccga taacaccggc gattttctta tttttttctg agcgataaag 3122221 cttattcatt cgatcacctc tgtgagtact ttagtttgat ggcgcctgtt agtgattctg 3122281 agaagacggt gatgttttga tcatgtgcct gatttgaagt gaacatcatt tctttttgaa 3122341 tcgtatcatt tttttccttc agcatctcta catccattaa ttcatgggac agcgtaccaa 3122401 gattgctttt cagctctgcc ttcactgcga gatcgtccgg aattgcaagc tctacatttc 3122461 cagtcgttgt ttttgcataa atggagcggc agtctgattc tgttacgtta atcgcaatat 3122521 ttccgttaaa gctttgaacg tcaatggatt cgcttttccc tcggagatcg atcaatccgt 3122581 taatggtttc cgcttctatc gtaccgcagc tgtggcttgc gagcttaatt tgcccgttgg 3122641 ccgtttcagc tatggctttt tcggctgtta aatacgagaa cgacagcacg ccgtttgtcg 3122701 ttttcgctga gaactctttt acatgtaaat gttcccctct gactggaccg ttaaacagct 3122761 tcacccgaat cttatcatac tccttctgag gaatatacaa agtgacattc gttttcatcg 3122821 tctttttctc agtacggata aaaaacttat tacctttgat ttcacattca atatgctgaa 3122881 gaaatgcgtg tctcgccgca tcctggctgt cagcgcgata taccttcgcc tggcattccg 3122941 ctctgatatc gtcatcttcc caagggacga tatttacgct gccattggca atttgcagct 3123001 caacactgga aaagtcagta tctttaaatt gaaaaatgtg ctgaacatca tacgcatggc 3123061 caaagtttaa atcaaggtca acttccttga cctttttcac agcagaatca atccagtcaa 3123121 acagcttggc tcctaaagac ggtttgccgc tttctttttt tgccgttgta aatggctctt 3123181 cctcgtcatg aacgtgaact gagagcgctg tgattttctc ttctttttcc ttgtagtcgc 3123241 tgtcaagctt ttcaatcagt gtcaaagctt cttgtgctgt aagctttcct tcctcaacaa 3123301 gcttaaggat tcgttccttt tcttgcttca ttacgatctc ctccccattg tctacttatg 3123361 ctgcacgcag gaccttaatg ccctgaatca cattccaaat gataatgcca atgacaacta 3123421 agaaataaat aaccgctccc ccgatgatta caaatacagg aagcaagctg tctccatcaa 3123481 tcgcaacggc tccgccaagt aaagcaataa aaaggaacag ccagccgaca aacggaacaa 3123541 tgtgagaaat aagagagcgt atcgcatggc gttttgtttc tttctcattt acaacaaaat 3123601 atgcgacaat cggcacaatg attggcgcaa tgaacacact gaaataacaa agtgatgcaa 3123661 taatagcttg attacggttc aattcattcc acactcctat tgtgaattgt ccatgacaaa 3123721 agatcaggga cgttttactt atttatacgt ttaaaatctc ttcaggtttc aaattcattc 3123781 tttagacatg ctccgattta cggaaattgg attttaaaaa gttttagaag tagaatcttc 3123841 cggctatacc gattacaata tgtaaaaagc ttacggcaac caaggaggct ggacaagcaa 3123901 tggagaaaga tcccagtgac tatacagtaa cacaagaatc agtgttaaag ctgattcagg 3123961 aacaaaaaag aatgaatcgt gaaatgatca ccgagcttga gcagattcac ggacccttcc 3124021 cgatctctca cgatatccaa tatataaaag tgctgctcga cagcagcaac acacatattg 3124081 ttcaagattt aatgagtgta agtaagcagc tgtataagaa gactttgtaa ttgcggaaaa 3124141 catatcattc attataactg aaacaaagct aaaggttaga tgacaatatc ttgccttttt 3124201 tgttttgaaa aaacaagtga ttccctggct gtcacaaaat gattgtaaca aaaaaagcct 3124261 gccggcacat ccagttaatg gactctgtcg gcaagctgta actatcagaa agagatagcc 3124321 gttcaaaatt aacgtaacaa ttgaagcacg ttttgcggct gttggtttgc ttgagcaagc 3124381 atcgcttgag aagcttgaga aggaatgttg ttctttgtga actcgctcat ttctttcgcc 3124441 atgtcaacgt cacggatacg ggactcagca gctgtcaggt tttcagaaga agcaccaagg 3124501 ttgttgattg tgtgctctag acggttttgt accgcaccaa gtttagcacg ttggtttgag 3124561 acattgttga ttgcagtatc aatactttca agttgtgtat caaaaggagt attagcaaaa 3124621 tctgttacat taagtgcgtt tactcctaaa gcagttgatg acatgctgtc aatgttaact 3124681 gtaagctgct ggccagcatt tgctccaatt tggaaagtga aaccatcagt ttcagtacca 3124741 tctaataact ttttgccgtt gaattcagta cgatttgaaa tgccatcaac ttcctcaata 3124801 agcgcatcca tttcatcttt aattgcacca agatcttctg cttgttgtgt acctgtgttt 3124861 cctgcttgaa cagtaagttc acttctaaac ctattatgcc gtaaagaaaa agcttgcctg 3124921 ctaagcccaa ggatggactt gccgacaagc tgtcccctct taacagaggg ttttaagatg 3124981 tagctgtttc ttttgctttc aagagcgatt tcatgcgtgt tttgtcacgt tcgataacag 3125041 gctttaaata acggcctgta tacgattctt caacttcagt gatttcctca ggcgttccag 3125101 acgcgacaat ggttccgcct ccggctccgc cttccgggcc caaatccaca atgtaatcgg 3125161 ccgtcttaat gatatcaaga ttgtgctcaa taaccagtac agtgtctccg ttgtctacca 3125221 accgttgcag cacgacaaga agcctggcga tatcgtcgac atgcaaacct gtcgtcggct 3125281 catctaaaat gtagagcgta cgtccggttg agcgtttgtg cagctctgac gcgagcttca 3125341 cgcgctgcgc ttctccgcct gacaaggtcg tcgccggctg gccgagcgta atataaccta 3125401 aaccaacatc ataaagggtt tggagcttgc gtttgatttt cgggatattt tcaaagaaag 3125461 aaagagcatc ttcaaccgtc atatcaagca catcagagat gctttttcct ttgtacgtca 3125521 cttcaagcgt ttcacggtta tagcgtttgc cgtgacacac ctcgcatgga acgtatacgt 3125581 caggaaggaa gtgcatttca attttaataa tcccgtctcc gcggcaggct tcacatcgtc 3125641 cgcccttcac gttgaagctg aaacggcctt ttttatagcc gcggaccttc gcttcatttg 3125701 tctgcgcgaa tacatcacga atgtcatcaa atacaccggt gtatgtcgca gggttggatc 3125761 tcggcgttct tccgattggc gcctggtcaa tgtcaatgac tttatctaaa tgatccaaac 3125821 ctttaatctc tttatggctg ccgggcttcg ctttcgcttt atgaagcttt tgcgccagcg 3125881 ccttatgcaa aatttcatta acgagtgtac tctttcctga accggaaaca cctgtaactg 3125941 ctgtaaacgt cccaagcggg aacttggcat tcactttttt caggttgttt tctgatgcac 3126001 ctttaatttc aatgtaacgt ccgtccggct ttcttctttc aggaggcaat gggataaact 3126061 ttttccctga taaatagctg cccgttaatg aatttggatc ttccatcact tcttccggcg 3126121 tacccgcaga tatcacctgt ccgccgtgaa tgccggctcc cggtccaata tctattaaat 3126181 aatctgctgc catcatcgtg tcctcatcat gttcgacaac aatcagcgtg ttcccgaggt 3126241 ctctcatatt tttcagagcg ctgatcaagc ggtcgttatc acgctgatgc agaccgatag 3126301 acggctcatc taaaatataa agcacaccgg ataaacgcga gccaatttga gtcgccagcc 3126361 tgatgcgctg cgcctctcct ccggacaatg tacccgctgc cctgctcaat gtcaggtaat 3126421 cgaggccgac tttgtccaga aagcttaagc gctccacaat ttcgcgcaaa atcaaattgg 3126481 cgatctgcat atccttctca gaaagggtaa gatctttaaa gaaggcaagt gcgtcggcga 3126541 cagacagctc ggtaattttc ccaatgtggc ggccgtcaat cagtacggca agcgcctctt 3126601 tctttaaccg atagcctttg cacgtcggac aagacttctg agacatatac tgctccattt 3126661 gctcacgtat gaaatcggag cctgtctcct tatagcgtct ttcaatgttg cgcaatacgc 3126721 cttcaaattg aatttcacct tcgcggattt gtccaaaatc attttcatat cggaaataaa 3126781 tcaggtcatc cccgctgccg tacagcactt tatccagttg atgcttcggc aaatctttga 3126841 ccggcacatc catatcaatc ccgtagtggg tgcagactgc ctcaagcagc tgaggataat 3126901 attgtgagct gatcggtgtc caaggggcga ccgcattctc cttcaatgac aaatcttgat 3126961 tggggatgac aagatcggca tccacttcaa gcttcattcc gagaccgtca cacgtcggac 3127021 acgccccgaa cggactgtta aacgaaaaca gacgcggctc aagctcacca attgaaaatc 3127081 cgcagtgcgg acaggcatga tgctcgctga acatcagctc ttcctcaccg atgacatcga 3127141 tcataacccg tccttcacct aaacgaagcg ccgtttccaa tgaatctgac agccgggctg 3127201 ccacgccttc tttcacgaca atccggtcaa tgactacctc aatggaatgc ttcttgttct 3127261 tttctaattc gatatcgtcg gaaagctcag ccatctcgcc gtcaattctg actctgacat 3127321 agccttgttt cctaatctgt tcaagcactt tgacatgagc gccttttcgg cccgagacaa 3127381 tcggcgccag cacctgaagc ttcgtccgtt ccgggtattc cagaattctg tccaccattt 3127441 gctcgatggt ctgggatgta atctcaattc cgtgttccgg acaatgaggc ttccctactc 3127501 tcgcatataa aagacgcaga taatcataaa tctcagttac cgtaccgaca gtagacctcg 3127561 gattgcggct cgttgttttc tgatcaatgc tgatggcggg agagagcccc tcaattgcat 3127621 ccacatccgg cttatccatt tgccctaaaa actggcgggc ataggcagac agcgactcga 3127681 cataccgtct ctgtccttca gcatatatcg tgtcaaaggc aagggaggat ttacctgatc 3127741 cggacaaacc cgtgacaacg acaagctgat ctctcggaat cgttacatct atatttttca 3127801 ggttatgcgc cctggctccc ttcacctcta tccgatccat agccatttgt tcatcatcct 3127861 tccgctttta gctctaaaag taaatcgcga agctccgcgg ctctctcaaa gtcaagcgcc 3127921 ttggcggctt ccttcatttc atgctccatc tgttcaacga ctttctggcg ttctttcttc 3127981 gtcattttcg acagcttcgg cgcggctttt gttttgtatt ccgctttatc ctcagctgct 3128041 actgtggcac gaatgacatc gcgaatttct ttatttatcg ttttcggcgt aatgccgtgc 3128101 tcttcgttaa accgctcctg ctgctcgcgg cggcgttttg tttcattaat cgcaatttcc 3128161 atagacttcg ttattttatc ggcgtacata atgacgcggc cttccgcatt tctcgctgcc 3128221 cgtccgatgg tctggatcag cgaccgctcc gaacgaagga aaccttcctt atccgcatcc 3128281 aaaatcgcaa caagggatac ttcgggaatg tccaaacctt ccctcagcag gttgatgccg 3128341 acaagcacat cgtacttgcc aaggcgcagg tcgcggataa tttcaatccg ttcaagcgtc 3128401 ttgatctcag aatgcagata gtttacttta atgccgattt cctttaaata atcggtcaga 3128461 tcctctgaca tcttcttcgt caaagttgtc acaagcaccc gttcattccg ctcgattctt 3128521 gcttgaattt cgccgatcaa gtcgtcaatc tgaccttcga ttggacggac gtcaataagc 3128581 gggtcaagaa gccccgtcgg acgaatgatc tgttcgacca tttcatctgt atgttcaatc 3128641 tcgtacggcc ctggtgttgc tgatacatac acgatattgt gcatatgctt ttcaaattcc 3128701 tcaaaacgaa gcggacggtt atcaagcgct gatggaagcc ggaagccgtg atccacgagc 3128761 acctgtttcc gcgcctggtc tccgttaaac atgccgcgca cctgaggaat tgtcacatgc 3128821 gactcatcca ccacgatcat aaaatcgtct gggaaataat caagaagcgt atacggcgtt 3128881 gaacctggag gccgcagagt caaatgtctt gaatagttct cgatgccgga gcagaaaccc 3128941 atttcacgca tcatttcaag atcatatctt gtccgctgct ctaaacgctg cgcttcaagg 3129001 agctttccgt tttcatgcat gaccttcagc tgctcctcaa gctccttctc gatattttga 3129061 atcgccttct ccattttctc ggcccgcgtt acgaagtggg atgccgggaa aatcgcaaca 3129121 tgatctcggt cgccgagaat ttctcctgtc agcgcatcta cttcccgaat ccgttcgatt 3129181 tcgtcaccga aaaattcaac tctgacacaa tgctcatcac gggatgccgg aaagatttcc 3129241 actacatccc cgcgcacacg aaatgtaccg cgctgaaagt cgatatcgtt gcgggcatat 3129301 tggatgtcta caagttttct gagcagctcg ttgcgctcaa tttccatttc agtccgcagt 3129361 gacacgacca tttcccggta ttcctcaggc gaaccgaggc cgtatataca agacacactc 3129421 gcaataataa tgacatctct gcgctcaaac aaagctgatg tggcggagtg tctcagttta 3129481 tcaatttcat cattaatact agcgtctttc tctataaatg tatccgtttg aggcacatac 3129541 gcctccggct gataataatc atagtagctg acaaaatact cgacagcatt gttcggaaaa 3129601 aattccttga actcactgta aagctgtcca gcaagggttt tgttatgggc aatcacgaga 3129661 gtcggcttat tgacttcttt aatcaaattg gacaccgtaa atgttttccc agttcctgtt 3129721 gcacccagca gagtctgatg cttcttgccc tcctgaattc ctttcacaag cttttcaatg 3129781 gctttcggct gatctccctg gggctgatat ttcgagacta actcaaagcg atctttcaca 3129841 aaaataagcc tccgtttctt taacgaaatc ttcctataga tatagtaaca caatggaaag 3129901 caaaatcact aaaaatacga actaaagttc ggtggttttt tatttccagc tgtttttgtg 3129961 tataaaaaac ctgcttttaa aacgtaaaag caggtattca gtctttatat tcattatgtc 3130021 cgatttattc ttcttttttc tctgcagctt ttttggccat atacagtccg ccagccacaa 3130081 gagacacaac atccaatcct acaataaaat acgtttctgt atagcctttt aaataagagg 3130141 caaacagcaa tgcagctgtt aaagcgatcg ccacataatg attaaaggtg actctagtaa 3130201 atagaacaac aagcataaaa gggaaaaaca atgcaaaaac ggcttttgta atcaacaaaa 3130261 accctcctca gggattcttc atctgatctg attatagtaa aaaatgaaga atcggacaat 3130321 cgtgcattcg ctccctctac ttacaccata ccccttttca gccaaaatca atcaccatat 3130381 ttgcattttg gtgccggtca aaacttattc catggtgccg ctgttctaat cagcggcact 3130441 ttttttatta catcatcaag tccgccgcca gattccgaga ataaaagaaa ataggcatac 3130501 agtaccagta cggccgcatt tttcaggata atataaccaa cttaactatt cattttattt 3130561 aggactttct gcgtttgaca gcattttcct gaaaacctac aattaaatga tagtgtttac 3130621 tatcattttt taaacacagg ctccgcaata aaaagactag agagaaaaac aaaatgaatg 3130681 aagaaaagag gggtttcaaa tatgtattct gttttatttc gccaggcaga agagtccagc 3130741 cagctggctg gagcaaaagg aatgaatttg attaaattga ccaaacacgg tcttcctgtt 3130801 ccggacgggt ttattattca aacgaatgcg ctcgcacgtt ttatggagga caaccagctt 3130861 caagagacta gtgaaaacgt cgaaggcggg atcatttccg gaacattttc ggatgagctg 3130921 aaagatgagc tgactagttc cttttataag cttagagaat catatcgatc cgtagccgtg 3130981 cgttcttcgt ctgcttcgga agatttagaa ggcgcctcat tcgcgggtca atatgaaacc 3131041 tacttaaata tcaaaacaga ggaagagttt ctggctaaag tgaaagaatg ctgggcctca 3131101 tttttttctg ggcgggtcag cagctataag aaaaaaatga acaatcaaat cgcagagccg 3131161 ttaatgggaa tagtcgttca ggggctgatc gattcagaaa tgtcaggtgt tatcttcagc 3131221 cgcaaccctg ttacccatga tgatagagag cttttaatca gcgccagcta cgggttgggt 3131281 gaagctgttg tttcaggaaa tgttacccca gacacgttca ttgttaataa atcttcgttt 3131341 gagattcaga aagaaatagg tgcaaaggaa atctacatgg agtctgcggc agaaggaatt 3131401 gctgaaaaag aaacgagtga agacatgcgc agccgttttt gccttacaga tgaacaagtg 3131461 attgaattgg ctgaaatcac aaaaaaaacc gaagacctgt acggatatcc tgttgatata 3131521 gaatttggaa ttgctgatca tcaaatatac cttctgcaag ctcgcccgat tacaaccatt 3131581 gatcaggaca aaaaagcggc agaagaaaaa cgcagcttca tgattaccga cactgatatg 3131641 aatgatttct ggcttaacat ggagtctaat attgaaggtc cggtgagtcc gttattttca 3131701 tccttcatcg tgccggcatt ggaatatggc ttgaagaaga gcatgcaaaa gtttccgatt 3131761 ggtgtagttg ttgatgaagt aaaactttat cgcggacata tttattccaa aaaccaaggc 3131821 ggacagcagc ctccttctga agactgcggc aaagagcttt tcccgatttt atcggagcat 3131881 atgtatgaca tcatcaatca cacatacctc cctttttacc ggacactgga ccagctcgca 3131941 caaactgagc ataccgcaga aagcgcactg gaagcttttc aaaaactaaa ggccttttat 3132001 ctcacggctt atgaagagca ctttaatatc gttttcccgc aaatcctttt aacaaacaaa 3132061 ctgcaagcga tgtatcagga cattcaagga gagtccgaaa acgctcattt ttacgagatg 3132121 ctgacaggaa aaatgaacaa atcactggaa acggaccgtt gcttatggct attttctgtg 3132181 gaagttcagg agaacccgaa ccttctggcc atttttgaaa acaacaagcc tgaacagctc 3132241 caggagaaat tggaacaaac agatgaggga agacacttcc tgaagaacgt ccatgaattc 3132301 ttgcaagaat acggatggag atctgttaaa agtcatgatc tgattgaaca aatctgggtg 3132361 gaaaatccgt atttcgctct ggccaatatt caaaattatg tccgtaatgg ctatcatttt 3132421 gacaatgaat ttcagaaaac aaaagaaaaa cgagagaaat tatacaatga attcttggaa 3132481 agcatagaag atcccggttt acgcaccgaa tttgaccgct attatcaatg gacactgaac 3132541 tctgcaaata taaaagatga tcaccacttt tatattgacg ccatgctgga tgccaaggcg 3132601 agaatctttc tgctgaagat aggtgaattg ctggcggaaa acggtgtcat tcaagatcgg 3132661 gaggaccttt ggttcttata tgacgacgaa gtggaacaag cgcttcttca ccctgtatcc 3132721 ctgcaagaaa aggctgaaaa acgcagacag atttttcatg agtatgagct ggcccaagcc 3132781 ccggcctacc tcggcacccc gacaaaagaa cagctcaaag cagctgaaga aattgtcggc 3132841 gctgtgatag aggatgaaaa aaacacagag aatcatattt ttggcattgc ggcatcaagc 3132901 ggcattgcga caggtccggt gaaaatcatt cgggacgcca atgaattttc tcaattcgcg 3132961 cctggagacg tactcgtttg caagatgacc acaccgctat ggaccagcct gtttcaagac 3133021 gccaaagcga ttattacaga cacaggcggc attttgtctc acgctgcgat tattgcccgt 3133081 gaatacggca ttccagccgt tctcggcaca cgcacggcaa ccgaaagact gcgagacggt 3133141 gacatcatca ctgttgacgg aagcagcggc aaaatcacag ttgtcagccg gtcctgatgc 3133201 gtccccctct ttcttataca agcggggcgg gtgtatactt gtcctgccag tatattcgtg 3133261 aggtgaaacg tattgagacc gacaaacaag agaatccttg atgctgccat gcagctgctc 3133321 gtcaaaaaag gatatcgcgc aacgactaca aaagaaattg cagaaaaagc aaatgtaagt 3133381 gaagcgacga ttttcaggaa ctttaaaaac aaacaaggac tagttgaggc tttgctttct 3133441 cagcattctt caaacagagg cagcattttg gaacaaacag aaggggattt gtacaaagac 3133501 ctgcttcata tcggaacctg tctcttggag gagctcgaac atagaaaaga tatcattaaa 3133561 atcagctttc gtgaaccggc catgtttcag gatgtcatta accacgtcac tgaatatccc 3133621 caatctatga aacagctatt ggttgattat ctcaaaacga tgggtgagaa aggggttatt 3133681 cagacaggaa atgaagcgga acatgccgac gtgttcatgt cgattatctt cggttatttc 3133741 attcaccgtc tccacttagg agaccgggtc atatcaatgc cccaggaaaa aatgctggag 3133801 catagcacag ctctatttgt caaaggaatt tctgctgatt aactccttgg cataataaaa 3133861 aggaggatcc caatgagctc aagaaaagaa tgggcgctga tcgtctcgct attattgggg 3133921 gccattctgg ttcccattaa ctcaacgatg atcgcggtcg cgctctcatc tatttcccat 3133981 acgtataacg agtccatcgc aagcatcact tgggtggtta ccgtttattt aatcgtgatg 3134041 gcagtcacac agccgattgc aggaaagctc ggtgacatgt acggcaataa aacaatgtac 3134101 ttatggggag tcggcctttt tctaatcgca tctctaggct gcgccctttc accgagtctg 3134161 ctcctgttaa ttgtctttcg ggcattgcag gctgtcggcg gggcattgct tacgccaaac 3134221 agcattgcca ttatccggca tgttgtttct gaaaaacgcc taccgaaagt gtttggattt 3134281 ttcggactgg gcgcgggact tggtgcagca ctcgggcctt ttatcggctc tatactgatt 3134341 gacagcttca gctggcattc gattttttgg gtcaacatcc cgttcctcgc cattgcttta 3134401 tttacggcat taacgatgtt tcctcaatat aaagaaaata aatctgacgc gccgctggat 3134461 atcatcggct ctctcttgct tgcaggcagc atcgtttcca ttatcctgct gacgaaaaat 3134521 gaggctccat ggggatatac tgtatacagt gtattgatac ttctttttgt tccgcttttt 3134581 ttcagaagag aaaaacgtac ccagcacccc atcattgact ttgcactgtt taaaagctca 3134641 acctttacaa atgcgaatct atcagtcttg ttaagcaatt tgatgatgta tgccgtctta 3134701 ttgattatgc cgttatttat gacgaaccaa tttgggctta atacatctaa cagcgggatg 3134761 gcgctttctg tattttcgat cttcatgtca gccagcaact gggtgggcgc gcagctccat 3134821 cacaaatggg gagccaaaaa aatcattttt ctttcatttg ccatgatggc tggtgcgaat 3134881 ctattatttt tgctgttaag cagctcgcat tctgtcttgt tcctcatgct ctctcttatc 3134941 cttggcgggc tcgcttccgg agtcggtctg accagcatgc aggtttcatc ccttgccaca 3135001 gtagaccccg gtatgtcagg agtggcatct gggattttct cgaccttccg ttatttcgga 3135061 agcatcattt catcagcctt aattggcctg atttcgggat atcacaccct atttatgatt 3135121 ctctttgctg tatccatcat cggcgttttt gtttcattgg gcatcaaatc tgatgaaacg 3135181 gcacggatag aaaaaaactc agcgtaacac aaaacagccc ggcatcgcat catcctgcgg 3135241 tgccgggctg ccttttatga tcccgaagcg actgcttcgt cttcacggtc atcctttacg 3135301 aagaggatgc ccaattcatg atgttctcct tcataagaag ctcgctggtc aaaacgaatt 3135361 tctccattca aaccgataat ttcaagcttt acatatgcac ggttatgctg aagcgcttca 3135421 tagaaatcag aaacgttctt aaccggtatg ccattgactt tcgttatgat ttccccgatt 3135481 ttcaattcca gatcctcagc cggcgtattg gggataatcc caagcaccat taagccctga 3135541 tcccttttcg agaaataaaa cggagccgcg ttatcattca ctctttgctt tatggacaga 3135601 aaaatacgcc ctaacaaagc ggtacagacc gctgcacccg caagcggcgt ccacagtaag 3135661 ctcgctgcac cgagaactgc gacggcaaga ccgagaatac aaacgcgttt cgctgtgatc 3135721 cttatactcg tttcaggcag cgatccctgt accctttgtc caaatccgac aaagtaagga 3135781 atccatagaa aatggaatga gccgccggga accgtaaaca cgggccacca gctaaggtgc 3135841 gattctaaac cattaccggg cacgagaagg aacagcggca aaagccaaac ccggtttgcc 3135901 agctgctgtc cgatcggcaa accgcggctg cttacgacaa gtgccggtga tgttctcaca 3135961 tgcgcagaac gataagcaac cgctccttca gtgataatca gcaaacctag aaacacagcc 3136021 acagccggcc aaacaactgc aaatccttgc ggaaatctct ccagaaaggg ctccgcctga 3136081 tatatttgca gtccaaaacc tatcagcata ctcacactga cgatatatgc agcagacatc 3136141 cagtttgcgc gaagagtgaa cgctgccgct gcagtgataa cggcaataat cgcaagtaaa 3136201 ccgagaggaa tcgatattcc gagtccacct aaaataactg acaaaagaag acctggaatc 3136261 agtccctttg tatatgtaaa tttcagatca tcataaatat ctgctattct tgtatgaaag 3136321 gtttttcgtt cccgtttgat tcttacatag ccgaaagcca aggttatgat gataaaaaac 3136381 cagaaaagcg ggtgtaagaa gaacaagccc gcgcttttta acagttcaat tccccattga 3136441 acagacacta tctctcaccg cctcaagcca aacatgttac tcatattcta tcaaatatta 3136501 aatggcttgg atatcctcag gagagtttat ctctcttgcg tcatccacag cgtgacattc 3136561 gatagtgaaa aatcctttaa atagtggttt acatccacat ccaataaccc gctgattaga 3136621 tgcatcgacc tttttatatc tgtcagatta attcctaatc gcttatggtt tttcattaag 3136681 tagttaaaat aatgtttggc gcattcctca ttaatgtcat ttactgattc gacattggtg 3136741 taattgacca aatatctgct gaacagcata agaagactta gtgcttttgt agctgaaaat 3136801 gttacgtctt gtgttctgtc ttttaattgt tccactaatt cataatattt ttttttcacg 3136861 cacaatactt gccctcttca attgtgaacc cccattttct ttatacagat aagcacgggc 3136921 cagtataagc agcagtactg gagtgctaac aagcattctc gctaacgtta ctctttaaat 3136981 acctgtcgtt cagctgccat taacctgatt actgttcttt ttagaacctt cttatattgt 3137041 atgaagtaaa caaagactag gcaacttgca aaagtttcat tttaaatgca tattaactcg 3137101 ttagaaagtc tctctcatat attgatatcg ggtaataaca gtcctttata aatgtttatt 3137161 tgtgaaaatt tttttaattt cttgtcaaaa actcattttt tatgtgactt atgatccata 3137221 atctctttaa gcacaaagaa acaggagatg aaataccatc tcctttaatt gacaaataat 3137281 gatttcaatg ctgtttgaag ctgcaaatca tttttttcat ctgatttttt cttttctatc 3137341 tgctgattta atgtctctgc agtgcgagtg tcgatcacac cggttttatt cagcttgttt 3137401 tgatcctgaa aagccataac cgcttttttc atgtctttgc tgaaatagcc atcctcacgt 3137461 cccggatcaa agctgagacc ttttaacaat acctgcgcat gcttgacgtc ttcattgttc 3137521 atgtccactt taagcggctc tttcagctgt aagggcccgg cggaaaaata atcgggctgc 3137581 ttaatcgcaa tggtcggttc aattcctttc ttatgaatcc agtttccatt tggcgtcagc 3137641 cacttgtaaa gcgttaattt gatgttgctg ccgtccccca ttggcacagc ctgttgaacc 3137701 gttccctttc caaaagacgt atcgcctaca acatcataat ggccagcttc ctttaatgcg 3137761 ccggcaagaa tttctgatgc agaggcactt cctttatccg taatcacatt gacagggtac 3137821 gcttttttat gggtcaatgt tgaaaaataa cgttttttat ctccattgcg ttcagcaatc 3137881 tgaatatacg gctgatcctt tgtaacgaaa tgcttaagaa tttcttccac actttgaaga 3137941 tatccacccg ggttgccgcg tacatcaatg acaagtcctt ctatttcttt tttctcaagc 3138001 tccctcagcg cttttgcaaa atcctctgcg gtgtgctcag aaaaagtaga gatggcaata 3138061 tatccgacag aatgcccctg tacttttttc tctgatgcaa aaaccgtttc gagcggaatc 3138121 tcagctctct tgatccggaa tgacaactgc ttcttcgttc caggccgctg aatcttcatt 3138181 gaaacgctgg accctttttt tcctcttatt tttaacacag cgtggtttaa atccttgccg 3138241 gccatcgatt ctccattgat gctgataatt tcatcattag gcttcaaccc ggctttttcc 3138301 gctggcgatt tcttgaatgg agaaacaata ataattttgc cgtcttccat tccaacctca 3138361 gccccgatgc cttcaaatga ggaatcaaga gaatcagaaa attgcttagc tgtctgcttg 3138421 tccatgtaaa cagaataagg atcatttagc gtagacagca ttccctggat ggctccctcg 3138481 agcagctttt ctctatctac tttttctacg tactcattcg aaattaactc atacgctttt 3138541 tcgattttgt ccatagcttt atcccgttca gagtcagctt gtgccgtcgc gggaactgct 3138601 gcagtctggg gcttatccat ctcaagcagg ttgattcccg catatacacc ggcgcctccg 3138661 aacagcatgc tccctgctgc tatcacagcc attatttttt gattcatcct ttactcctcc 3138721 tgtatgccag actgtcttta ccaaaaccta gagatagtat atgtaaagga tggagatttc 3138781 atgtaatcat agaagaaaaa gaaggcaaat gaaaagccgt cccgaaaacg gaacggcttt 3138841 ttcactttat actcgcagaa acttgcggat ggaagtcaga cttccccata ctccaattac 3138901 tgcgccgatt gcaatcagca ctagcgaaac ttggaataca aatggattat aaggaagaag 3138961 agagacaaat gatccttgaa cctttggaac gacccatccg atgacgtatt ggtaagtgct 3139021 cagcaccagt gcaatcggaa tcacagaacc gaatacgcct agcagcaatc cttcaaggaa 3139081 aaacggccag cggataaacc agtttgtcgc gccgacaagc ttcatgattt caatttcttt 3139141 tcttcttgcg aaaattgtaa ttttaatggt gttggaaatt aagaacatcg ccgtaaatac 3139201 caggccgata attaacgcga ttccgatgtt gcgggaaacg ccgaccactt taaacaaacg 3139261 gctgacctct tcttttccat aagtgacttt ataaacatga tccatttttt cgatcttttt 3139321 cgccacgttc ggcgtatcat gcggatctgt cgttttgacg acaaacgcat cattaagcgg 3139381 gttttcctga tccttcattg tcagggattt tccgctgtca ccaaaactgt caaccagctg 3139441 gtcaagctct ttttctttag atgaaaaagt gacactctga atgcccttca gttccttaat 3139501 atcgttctga agcttgtcct gtgccttctg atctgcagtc agatcaatca gcactttgat 3139561 ttcgacttgt ttttctgcat tcgtggccat gttattcaaa ttcagcataa tcactaaaaa 3139621 cacgccgact aaaatcagcg taacggttac agcactaatg gatgcaaatg tcatccatgt 3139681 gtttctcccg agagatttaa aactctcacg caagtggcgc ccgagaattt taatcatatg 3139741 aaccatactc ccctcttgac tcatcacgca caatgatacc atcttcgatt gcaatgacac 3139801 gtttcttcat ggtgtttacg atttctttat tatgtgtcgc catcacgact gttgtcccgc 3139861 ggttgttaat ttcctccagc gtcttcatga cttcccagga cgtatccgga tcaaggtttc 3139921 ctgtcggttc atcagcaatg acaacatcag ggttgttcac aattgatctg gcaatagata 3139981 cacgctgctg ctccccgcct gaaagctggt caggaaattg tcgcgcttta tgcttcagct 3140041 gcacgagatc aagcacttca agcacccgtt tcttaatgac agacggctgt tctccaatca 3140101 cttcaagggc aaatgccaca ttttcaaaaa cagtaagttt cggaagaagc ttgaaatcct 3140161 gaaagacaac acctattttg cggcgcacga aaggaatctc tttttcttta attgtcgcga 3140221 gatctttatg attgattaaa atttgtcctt ttgtcggttt ttcttctctg taaatcattt 3140281 taataaaagt agatttacct gctccgctcg gaccaacaac atacacaaac tcgccgggat 3140341 gaatggtaac agaaatccca ttgagtgctt ttacgccgtt cggataggct ttatatactt 3140401 ccttcatctc tatcatgaaa tcacctaatc ttttatatca ttttatctat cacacggtca 3140461 tactcttcga atgcattcga caatttatga cccattcatt tgtaaaaaga tgaaaaatct 3140521 gaaagttccc tttttcaata cacttcatta tacgtcaaat ttagacataa tactattaca 3140581 gtttcttttc attcatattg tcaaggcata aaaacatcct tgccagcact cggcaaggat 3140641 gtttttatct tacttttttt ctgacagcca tttggcaata acagcggctt cgttatcatc 3140701 tacaagcccc tttggcatat tgccgcggcc gtttttaata atgctttcaa ttttgtgttc 3140761 atcgtatttg cctccgacct cttggagatt aggccctgac acaccttcta aatccttgcc 3140821 gtggcagcct acgcagcttt gctgatataa ttcttcccct tcagatgcag tggcttccgt 3140881 cttgctgcca gtgtctgtct tctcttcttt tgcatcgttt gatccgcagg cagccaacag 3140941 aacagaaagc gcaaatccaa tcattagtat cgataacttt gatttcatgt tgagaagcac 3141001 aactccttta cgatctcttc catattataa cctcgtttaa gcgcgtttga aaccctcgcc 3141061 cagcacctcg ctcgcgtctg ctacaattac aaaagctgac tcatcaatct gtttgacgat 3141121 ttgtttcaat ttggtgaatt cagtttgccc aaccacgcac attaaaatcg gacggtcatc 3141181 gtcagtatat ccgccgactg cagaaatttt tgtcacgcct ctgtcaatct tctgtaagac 3141241 agcctccttg acagcctgct cctgctttgt aatgatgagc gccatttttg aacgattaaa 3141301 gccgacttgc acaacatcaa tggttttgct ggacacatag acgccaagca tggcatataa 3141361 gccttgctca atattaaata caatcatagc cgtaacaacg atcattccgt caatgatggc 3141421 gagacacttc cccaatgaca gaccggagta cttatgaatg atctgtgcag ccaaggctgt 3141481 acctcccgtc gaacctttcc ctaagtacac aataccaatt ccgataccta tcccgacacc 3141541 gccaaaaatc gccgccagga gttcatgatg agtggcgggc tgaatatccc ttgtcagaaa 3141601 cactactagc ggcaaaaaca cagaacctgc aagcgtcttt agtccaaatt tcccgccgag 3141661 caaaatgacg ccagcaataa ataaagggat attaataatc cactgtacat acgctgcttc 3141721 aaaaccatat gattgtaaaa tcgtactgat cccgctgacc ccgccggcgg caatcttatt 3141781 cggaagcaaa aatacattaa aggacacggc cgtaatcgct gctcctatca atatgtatac 3141841 ataatcccgc aaaatccaca atgttttatt ccgtacgtcc atcatatatc ctccgtttct 3141901 tccaatgctc tccgatagca ttttaatcct tccctgatta gatgtaaata acacccaaat 3141961 acagtggtaa tatgctaaag cagcagtgaa atcaaggata taagaaataa aaaaacacac 3142021 ccgtatgcat caggtgtgtt tttcagctta tgaaagctta gaacgcaggt aggcatcaat 3142081 aaacgtatca atgtcaccat ccattacagc ttgaacgttc cccatttctg tattggtccg 3142141 atggtctttt accatggaat acggatggaa tacataagaa cggatttggc tgccccagcc 3142201 gatttctttt tgttcaccgc gaatttcatc cagctctgcc tgctgctctt caattctgcg 3142261 ctgatacagc ttggccttca gcattttcat ggctctttca cggtttttaa tttgtgagcg 3142321 ctccgtttgg catgtcacaa ctacgttcgt cggcaagtga gtaatccgaa cggctgaatc 3142381 cgtcgtattg acgtgctgtc cgcccgcgcc gcttgcacgg tacgtgtcaa ctttaatatc 3142441 ctccgtacga atatcaatat caatttcatc gttaaattca ggcatgactt cacatgaaac 3142501 gaaagatgtg tggcggcggc ctgatgaatc aaatggtgag atccgcacaa gacgatgaac 3142561 acctttttct gctttgagat acccgtaagc gttgtgtcct ttgatgagca atgtcactga 3142621 cttgattccc gcctcgtcac ctggaaggta atcgagagtc tctactttaa agccgcggcg 3142681 ctctccccat cttgtataca ttctaagaag catagagccc cagtcctgtg actctgtacc 3142741 gccagcacca gggtgcagtt ctaaaatcgc gttattttta tcatacggct cgctgagaag 3142801 aagctgaagc tcaaactcat tgaactcttt tgttaatgac tttagttctt tttcaagctc 3142861 aagctggaga tcagtgtccg gctcttcttt caaaagatca tgagtcattt gtaattcttc 3142921 gtgggattca ttcaattttt tatacgaatt gacataatcc tttaaaccgt ttgcttcatt 3142981 tataaccgtt tgagcttttt gctgatcatt ccagaattcc ggatcagcca tttgttcatc 3143041 tagctcagca atgcgggcct cctttgattc gaggtcaaag agacccccta aagtccgcta 3143101 aacgagaagc catattttcg agctctgctc taatttctga taattccatt tcattcacct 3143161 cattaaaaga tccgcaggcg cctgcaggcg ccgcggtcag taaacttgcc ggggcgaact 3143221 attcagtacg gccgcagcaa tttttatatt ttttcccgct tccgcagtgg catggggcat 3143281 ttcgtccgat atcaaccact ttgcgaaccg gtgctttctt tgcttttttg ttatcgtcgc 3143341 cttcttgcgg ctgatgagct gttgtttgac cttgtacaac ctcttcacgc tccagattgt 3143401 tttcaatctc agctttcatc acaaattttg cgacttcgtc ctcaattgat tcaatcatat 3143461 gctcaaacat cgcaaaacct tccatttgat actcacgaag cgggttcgtc tgcgcgtaag 3143521 cacgaaggtg aatcccttgg cggagctgat ccatcgcatc aatatgatcc atccatttag 3143581 aatcaacggc acgaagaacg ataacttttt cgaattcgcg catttgctct ttgccgaatt 3143641 gctcttcctt ctcattatat tttgtgatga tgcgatccat aatgagctca agcatttcat 3143701 ccggttcttt gccgaagata tcgctcttct caagtgcacc ttcatcaaga taagttgtgt 3143761 tgataagatc aactagaccg tcaagcttcc actcctcagg aagctcttct cttggcgtat 3143821 aggctgcaat tgcgcgttcg agagaagact tgatcatatt ttcaacgatt tcacgcaggt 3143881 tttcagagtc aatgacttca aagcgctgct tataaatgac ctcacgctgc tggcggagaa 3143941 catcatcata ttgcagaagc tgtttacgcg aatcgaagtt attgccttcg acgcgttttt 3144001 gagacgattc aaccgcgcga gataccattt tgctttggat tggagtagag tcgtccatgc 3144061 cgaagcggtc aagcatcgcc attgtccgct cagctccgaa tctgcgcatc aattcatctt 3144121 ccatagaaag ataaaattga gtaatccccg ggtctccctg acgtccggaa cgacctcgaa 3144181 gctgattgtc aatccggcgt gattcatgtc gttctgttcc gactacagcg agcccgccaa 3144241 gctcttttac accttcgcca agcttaatgt ccgttccgcg ccccgccatg ttagtcgcaa 3144301 tcgtaactgc gcctttttgg ccggcctctt caatgatctg cgcttcacgt tcatggtttt 3144361 tggcatttaa cacttgatgc ggaattcctt tgtttttaag cagcttagaa atcaattcag 3144421 atgtttcaac ggcaaccgta ccgactagaa caggctgtcc cgtcatgtaa cgctgtgcga 3144481 catcctccgc aactgcctta aactttcctt ccatcgtgcg gtaaattaaa tccgggcggt 3144541 catcacggac aacaggcctg ttggtaggga tcgtgacaac ctgcatgttg tagatgttgc 3144601 ggaattcttc ttcctctgtc ttagctgtac ccgtcatacc ggcaagtttt tcgtacattc 3144661 ggaagtagtt ttggaacgta atcgtcgcca aggtcatgct ttcgttttga atctcaagcc 3144721 cttcctttgc ttcaatcgct tggtgaagcc cctcactgta gcggcggcct ttcatcagac 3144781 gtcccgtgaa ggaatcaaca ataacaacct gtccgtcttc cactacatag tcaacgtcct 3144841 tttgcatcgc aacgtgagct tttaaggcct ggttgatatg gtggttgagc gcgacatgct 3144901 tcacatcaaa gaggttatcg atgccgaatg ctttttccgc cttcgtcatt ccttcttcag 3144961 taagctgtac agcttttgtt ttgatatcgt acgtgtaatc cttctccgct tttaacgtgc 3145021 ggacaaaagc atttgcctgt acgtacagct tagtggattt tgcagcttgt ccagaaatga 3145081 taagcggtgt tcttgcttca tcaattaaaa tagagtcaac ttcatctatt accgcaaaat 3145141 gaagcgggcg ctgaaccatc tgctctttat aaagaaccat attgtcacgc aaatagtcga 3145201 agccaagctc gttgtttgtg gagtaagtaa tatcagcggc ataagcttcc cgtttttcgt 3145261 cttttgacat tgagtttaaa ttcaaaccga cagtcaaacc gagaaactcg aaaattttcc 3145321 ccatttgctc agcgtcacgg cttgccaagt attcgttgac agtcacgacg tgtacgcctt 3145381 taccggttaa cgcatttaaa taaacaggca gggtagacgt taatgttttc ccttcccctg 3145441 ttttcatttc cgctatattt ccgtcatgaa gcgccacgcc ccccatgagc tggactttaa 3145501 acggaaacat gcctgttacg cggcgtgaag cttctcgaac aacagcgaaa gcttcaacaa 3145561 gaagatcatc cgttgtcgcc cctttttcaa gacgctcttt aaattcaatt gttttatgtt 3145621 tcaatgcgtc gtcagagaga ttttcatagt ctccgcgaat cgcatcaata tcgttagcaa 3145681 ttttttcgta tctattcagc gtacgttttg ttggatcaaa cattttattt aaaattccaa 3145741 gcatttataa cgctcctcta tcatcacacg cctattttag aggcatgtat aaataattta 3145801 ctagtccatg tatacctctc attatcatat catacctttt gttatttcca aagaatttgc 3145861 aaataagaaa aacaaaaacc ttccgcggac atcacggaag gcttctcttc attattcagt 3145921 cggttcaatt aagccatatt tcccgtcatt tctgcggtac acgacatttg taaggtttgt 3145981 ttccgcattt gtgaaaacaa agaaattatg gccgagcata ttcatttgca agatcgcttc 3146041 ttcactatcc atcggcttta aattaaagcg tttctgacgg acgatgtcca agctctcctc 3146101 ctcttctatg tcatcctgaa ccgcaatatc tgtatcagag ccaagaccgt ttgccaataa 3146161 atattttgga gagccctgct cacggaattt acggtttact ttcgttttat gcttacggat 3146221 ttgacgttcc agtttgtttg ttgcgagatc aattgcgttg tacatatcct cgttatgcac 3146281 ctcggaccga agcgccagat ctgtcatcgg aatcgtaacc tcaaccttag actccttgtc 3146341 attgtaaaac ttcaagttga cgttcacatc agcatccacg ctatggtcaa aatagcgctc 3146401 cagcttgccg atcttcctct cgacatgatc ctttaacgcg ggtgtcactt caatattttc 3146461 tcctctgatg ttatagttca tcaaagaacg cctccctttt attaaggata tgtatctatt 3146521 tctcttttac cctttacaat tcctgctgaa acataaatct tttgtgaaaa ttcagtgaac 3146581 tttgtcgaat tttgtttgta tttgctctgt tattggcggt tcggaggtat atgtatatgc 3146641 tgattgaacg aaacaaatac ctcacacacg cctaattgat taaaaagggt tccatacatt 3146701 gatgaataga cagcatccat tttctataat gaatcagaaa atgttccttt aaatactcac 3146761 agaactcatg agagggaaaa gagaaagaga ccaattgatc aaactccgca aaaatttggt 3146821 caaatgcttt cacacaaatt tcagcacacc gcgaatccat aatgaagaga agtgttgaat 3146881 gtgttgaatc caaataaaaa aaggcttgga tcagatcttg gtagatccga tccccttctg 3146941 tttttgataa attctcttca gcctctatca aataacacaa cccctcttcg atggtaaaaa 3147001 gaagatgata ataagctgat aaaagcgtat aatcttcaat gctcttcaag gcactcacct 3147061 atttacgctt gtcataatat gtgccgtcaa tcgtaatgtt gttataaggg tttaaatacg 3147121 tcgtatgcat cacacgtttt cttttcatct gctgaagttc tgttgcgatt gactgcttca 3147181 gtctttccat ttccttcaca atcagctgat cccatgtcaa aataagtttc atctgctttc 3147241 gctcttcttc tgaaagcggc agagatatct cctgaatcag ttcagaccgt gtagccacaa 3147301 agtcttcaat ttgctttaaa agttcatcgc tttccggcgt attttgtatg tgtgacagca 3147361 tactcttcgt ctcagtgtat agttgatcta tattattcat gcgatcccgc ctgatccgtg 3147421 ccggtccttc cgctcacttt gaatggcttg tttccaagca tcgcgaaaat ctgttacata 3147481 accttcaacc tcagccagca tgcccgtatc atttttgata tttgcctgta ccaatctgcg 3147541 atacatataa tcgtacatcg cacccataga agcggaaagc tctatgttac ggttaagtgt 3147601 aaaatttaat tcctgaataa tattttgcgc tttaatcaga ttttcatttt tacgttccat 3147661 atcatcattc tcaatggcct gagcggcaag tcttataaat ttcaaacagc cattatacag 3147721 cataagcgtc agctccccgg gtgtagccgt attcactgaa ttttgctgat aggctgtata 3147781 tggattttgg atcgccatgt gtcatcctcc aaattacatt tattgtacaa gaagctgtga 3147841 taaataggac gcttgttcgt tcattttttg aatcgcagaa tccattgcac tgaattttga 3147901 ataatagcgg ttttctatgg tattcaatct gtcctgcata tcagttattt cagtacttat 3147961 cgagtttaaa ttttttccaa tggaatagct actagctccc attgtcgagt tcccagcttt 3148021 agcttcaata cttttcacag tacttctaag tgtattagta atccgcttca taataccttt 3148081 atcgctatag ttactatcat ttgttccact tgtaaaaaga ttagcaactc cttgaggatc 3148141 ttctgctatt tttgctttca atttctcttc gttaatctct aagtgccctc gcagttggta 3148201 agcacttgaa gttgtgatgc caaattcagt taattgatag gttttcccat ccgcattcac 3148261 ttgagtataa aagtcagtcc gcatttggtt cgtgccagtg ctgatgcttg aatcgtttct 3148321 cagcaatccg cttttcgcct tctcctccca gagctctacc tctttatcgg acatggcttc 3148381 tttttgttca ctcgtgagtg gcgtatagtc tcggtatttt tcttctttca gcttttcatt 3148441 caggctgtca accagttcat tgtatttatc tacaaactct ttgatttggt tataaatccc 3148501 atcaacatca gtagaaacag atgtggtaac agggcctgtg gctgcagttg tatttttaat 3148561 cgaataagta acaccattca ccgtgaaatt gtttgtcagc ttctccattt caaagccgtt 3148621 gattgtgact ttggcatttg tgccttcttt gtaagcagta agcttattat cagcatccaa 3148681 agaaaaacca agctgaccgg acataaagtc agctgtagca gagtctgctg cctgtatgct 3148741 tcctcctgca cctgttgctt tagaagaaaa cgcaatcgtt tctacgtact ctgtaccatt 3148801 ccaaatttta tctttaaatg ctgatactcc tagatctgag ctgttaagtt tagaaatcac 3148861 attatcaatc gtatcggcac tcgtcacact aatgttcact gtttttgctg ttgtttcgcc 3148921 aggcgcaaca acgttaaatg ccaaattgta atcgccttgt gtgtatcccg tataattgtt 3148981 tgccttatac gttgctgcag ttgccaagct cgccacttca acagtagacg aagaatttgg 3149041 cgcacttacg cttcctgtag cagttaacac agactcatta gagcttgtca cagttttgct 3149101 ctgatacgtg ctcggatatg tcaacgtatt tttagacata taatcttgca attcttttat 3149161 ttttgagttt acttcacgat agctgtcacg ctgccattca agagtctgct ttttttgtgt 3149221 cagcttatca agcggcgctc tttctgtctg catcagcttt gatacgatat catctatatc 3149281 cattcctgac gccagacctg ttattcttgt gaccatctca aaccactcct attctacttt 3149341 ttttcatcta caaataaccc aagaaattca gtcatagccg cataaaaatc aagccaccgt 3149401 tttggtggaa tttcgcggat cacttcattt gtagagtcct ctattacctt tacatagtat 3149461 tcatttaact tgtcatgaag ctcgaacttc agatgaactt gcgaaggttc caaaagcttg 3149521 ttcatttccc ccaccatttc agcaagattg gtatatgaaa cttgatgaac aggaacctcg 3149581 ttatcattat ctttctgatt atgtatttga gtatcataac gatcccaaac aggttgtaac 3149641 gtagtgagcc tttcaatgtt caattgatca tcccctatgc cccaatctat cgtttatatc 3149701 gactaagtcg agataagatt acacatattt ttggaaaaaa atcttctgtt ttagatttct 3149761 tgtatggaaa tacatttata aaaagttagt ggagaatccg gttattatat catgagttag 3149821 tgacaggatg aggaatgatt aggagataga aatttaaatt aaaagaccct ggcaacgcca 3149881 aggtcttttt taaaattaac gtaataattg aagtacgttt tgcggctgtt ggtttgcttg 3149941 agcaagcata gcttgagaag cctgagaaag aatgttgttc tttgtgaatt cgctcatctc 3150001 tttagccatg tcaacgtcac ggatacgaga ctcagcagct gtcaagtttt caccagaagc 3150061 gcttaagttg ttaattgtgt gctctagacg attttgtacc gcaccaagct tagcacgttg 3150121 agaagaaact tggttgatcg cttcatcaac aactttcaat tgagcatcga aaccgatatc 3150181 agcagtatct gctgcattat ctgcgaattt tgttacgtca agatcattaa ctgaatgaag 3150241 agctgcaatt gaaccatcag cttctttaat tccaagagcg tcagcaccca tatcctcaat 3150301 atttacagag atttgctgtg tagcatttgc tccgatttgg aataccaagt tcttttgatt 3150361 tgcaggagta gctgtgtcaa ctttgtaagt gccatcgagc aatttcttac cattgaattc 3150421 tgtacgattt gaaataccat cgatttcatc tgttaaagct gaaatttcat cttgaataga 3150481 ttgcaaatca gttgctttgt cctgagttcc agtgtttcca gcttgaacaa ctagctcacg 3150541 aacacgttga aggatcgcat gagtttcagt taatgcaccc tcagctgttt ggataagaga 3150601 gattccgtct tgagagtttt tagaagccat ttcaagacct ctgatttgtc ctctcatttt 3150661 ttcagagatc gcaagacctg ctgcgtcatc tcccgcacgg ttgatgcgaa gacctgaaga 3150721 aagtttctcc atgttctttt ggctcgcact gttgtttgaa gacaaacggt tcagtgtgtt 3150781 aagcgctgca atattgtggt taattctcat tgttttgttc ctccctgaat atgttgttaa 3150841 ggcacgtcct tgtgccctta ttttgtaact ggctgagtct tttgcgcctc ctcccggcta 3150901 catcattaat atcggattgt ctctgatttt gttaatacaa aaataaaaaa atcctcactt 3150961 tttttgtgag gataatgcgg agatcacatc gctggataac gctgctgcac ggttattttc 3151021 ttcctgaatg gtcaagtaaa tttctttcct gtgaatatca atatgctttg gggcgtcaat 3151081 tccaagcttc acttgatccc cttcaaccgc aatcactttt acttcaatat cagcacctat 3151141 ttgaatcgct tcgtttattt tccgcgataa aactagcatg attctcctcc aatcggatgc 3151201 tttgtcgtat atgaggagtc gtgtaaaacg acttgcttag ccatcatgtt cttgcgattc 3151261 acaataatgg gagccaataa attcgcagta gacttttcaa atggctctgc catagtcaat 3151321 attgtcatga cttctacgtc ttgaatatta tcgatatcca aaagttcagc agttgattca 3151381 tcaagatcaa attcataatt cttaaaaaag ataaacggac ttacgacgat aaacgcaaga 3151441 ttttctgaag tgacggactg cagtgccacg aatggagagt cttctgaaag cggaagtatg 3151501 acgaactgtt tttcttctaa aaagcctgga atcccgcttt caaaaagaat gatttgttct 3151561 tcttttatgt tcatttggcc atggtacttc gtatgaatga tcattgttca cgatcctttt 3151621 ctttttactt ttcgggtgat tctttcgggt attctacatc tatatttaaa tcagggtatt 3151681 gaagcatgtc aaccttaaca tttcctggcg tatattcaac aattggctta tgcggctcag 3151741 cctgaataac aggctttcgc ggcgtaatct gcacatcaag ctgtgacgga gtatattgta 3151801 ttttcaccct cgaaagagaa ggagcataat tttcgcctaa ttgaatttgg tgcatttcag 3151861 agttcctcct tgcttgtgaa gcgattgggt tccccttatt ttcaatcttc ataagctcgt 3151921 cgccttcttc tgcagtgcgt gctattccct ccattacatc ctcatgccct tgttgggcgg 3151981 cttcttcaat tctcttgaaa acatgctttc tgtctaattc ttcccatgct tgtgtctggt 3152041 caatcgtgag ttttccaggt gtcaccgata tttccatttc cgcactcggc tgttcgatct 3152101 ctagatcagc ttgaggctgc tccattttta agctggcagg cgtcgttgtt aaaccaattt 3152161 ttccttgaac actatgcata atcaatctgg gaatctgcat cactctacct cctgaactat 3152221 aaaaaaagcg aactcctaag agccgcttac tttaaaaagt caatcaatgt aggctgaaca 3152281 atttgcgcat taacggccag agtagccctg tgcacacttt gctgcgcaat aaattcagtt 3152341 attacttctt ccagttctac atcttcattg tctgataaca ctttggtagc tgtttcttct 3152401 tgcgctgaca gtcttgtatt aaccagttca agacgattat atctcgctcc aagatcagat 3152461 cgttcagcgc tcatgccgtc agaaaaatga tcaatatcat ttaaaacact gtccatgcca 3152521 tctagcgaac cagaatttag tgctttctca aaagaatcaa gcatttcaaa tacattctgc 3152581 ccgctttcag aagtgcctcc aaaagctgac tttggatctg aattcacttt caatgacata 3152641 ttatttgata tattgactac gacatcagct gtatcagaaa ttgtataagt tccgtctccg 3152701 ttatctgtaa ccggaggctt atctgaattt gtgccattaa agatatatct gccgttcact 3152761 tgtgtattcg caatatttaa aagctgttcc tttaactgct ttacctctac gccaatcgct 3152821 tgccgctccg gctcgccgtt tgtatcattt tgagcttcaa ccgctaattc tctgaccttt 3152881 gacaagatgt caattccttc tgtaatgttt gtttctgtgt tttcgagcca ggtaaaggct 3152941 tgagaagcat tgcttttgta ctgctgcact tgagacagtt gcgtattata ctttaagctt 3153001 ttcattgcta ctacaggatc gtcggaagct tttgagattt tttttcctga agaaatctgc 3153061 gactggagtt tatccagctt cgagtagctt gaaccgatat atctcagtga gttttgctgt 3153121 atcatgcctt gtgttactct catgtgactc tacctacctt cctccaacac ccatgccgtt 3153181 gatcacttta tcaagcaatt cgtcttgtaa agtcaccatt cttgcagctg cattgtatgc 3153241 gtgttggaat tgaatcatat tcgtcatttc ttcgtctaaa gaaactgcgc tcatttgctg 3153301 acggtttatg tcagcatcat tcagctgtgt ttctgtatta gacgccagtc gattagcctc 3153361 ttgagcttcg atccctagct cgccaatcag acccgcataa taatctaaaa cactagtttc 3153421 tttaccgtta atggttattt taccggttaa aacatttgct aattttgtag catttgcgtt 3153481 atcgttggct gcgccagtca gtgagaaagc aatgtttgcg ccttttgaat ctattatgct 3153541 gtcagccact ttgatcttgc ccgccgcgcc cttggcaggt tcagtttcac cgccagtaaa 3153601 atcaaaaaag tctccgcctt gttcaccgct cttggtcaca ccatttctgt gcacttcatt 3153661 gaaagctttc gcgaattcaa gcgccatatt gtcaagatca gaaagcattt ccgggtatac 3153721 gcccttttct tggccatctg ctgttatata cccataagac tctataaacc ctaaaaggga 3153781 tcccttgctg ctaaaggact ccgcctgtac agctgtatcc ccgattgaaa tacttgatac 3153841 taacccagtt tcattatcat agttggctgc aagttctgaa acctcgtaat ttttaccgtc 3153901 caaaacagtt cctagcgact gtttattttt atcaaggatt tcaattgata cagttccttc 3153961 agcagatgca agtgcattcc cgcctgattt gttgtagctg actttgatat caaccattga 3154021 ggataattta tcgatcagca aatctcgctg gtcatataag ccattcggaa gaagcccgac 3154081 cggctctact tgtgcaattt gcttatttaa actgtttaac tgagaaagca gagaattgac 3154141 atccaacaca gttgtattta gctctgcttt taaattcgat tggacatttg taagtgattc 3154201 agaaatataa ttaaacgttt cagctacagc ttgtcctttt cgagcaacaa cagaacgtgc 3154261 actttcttca tttgtattat tcgataattc ctgcagggaa ttccaaaacg aattgagcac 3154321 actgttcaag ccgctgtcat ccgtttcatt taaaacgcct tccatttggg acagcgcttt 3154381 tgccttcgtg tcatagtatc cggcactgtt gttttgaaga cggtattggt agtcaagaaa 3154441 gatatctctt attctctcaa ctgattttcc ttgaacgccc gtacccattt gtcccgctgt 3154501 tttttctgca tttttagata cagcagggaa atagtcagtt gcctccaatg agacccgctg 3154561 tcttgtataa ccatcagtat tggcatttgc cacgttattt gcagtagtgc ttaacgctgc 3154621 ctgctgagcg cttaacgccc gccttgcagt ttcaagcccc ataaaggtag atgtcatttt 3154681 ctgaattcct ttctgctaag cttttgaatc aaacagtttc attttgctac ttttcggcag 3154741 ctcagcttta attgatttgc tgtaattgaa gttattttcc ttaggaacca gcatatcgta 3154801 cgaaatagag atgaattgca gcgcgtctct tgtcagctgc ctattcatct catttacttt 3154861 tttcagacgt ccgagaactt gagaaagaga ttcgtatagt tgttccagct cttccttttc 3154921 actgcctgag gttttggcga tacatgcgga aatagtatta ttttcgctat atccgagaaa 3154981 ggccgaagtt gttttgatcc ggtcatcttc tgtctgcgtg attgcttgaa tatatttttg 3155041 ctcttttgtc aaaatgttag aaagctcttt tgttttgccg gctttgagcg cttccgtctt 3155101 ttcttcagac agcgtgagca ggtgctcatg cagaacgcaa agtcgcttca attgttcaat 3155161 aattgccttc gctgacatgg gctttctcct tttttattgc tttttataaa aattaatcat 3155221 atttttcgca atatgatttg cgtctacttt gtatgacccg ttttcaattt gcgctttaag 3155281 ctgcgcaatt ttttcctgtc gtgaaccagt gactgcgtcg gatgcatgtt gcatttcttt 3155341 agcctgtgat gaaatttcaa ttttatcttg aggttgtgca acagtttttt gcaccgcttg 3155401 cttatcataa tttttttgat atggattaac ggattgtgtt ccaaattgat tgattttcat 3155461 aggattcctc tcgctttccg ttgcagtctt taaacaatct taaccctttt atcgactgcg 3155521 ttttcagtta gtttagggaa tcagctgttt ttggtattat aggcatagta tgtgtctttt 3155581 ttactatttt ctttctcgat tttcagagca tcctcgtggt tcaaatgatc catttgatcc 3155641 ttaatatcag actggcaagc cttgcagaac ttgccttctc taatcgatgt cccgcacctt 3155701 tcacaagggt atgccaaatt aggaagatga gtgatctgaa ttcgcttctg cctgatgaat 3155761 ttcaatatca gctcttcttc cacacctgtt tcctcagtta tccggctcaa agttgattgc 3155821 cggttttcct gttttcttaa aaatttatag acagtctcaa atgatttttc ttcttcctta 3155881 atacacgcct gacatacggt ttgcagcttt gtttttaaaa ataaagcatt gcatttcgga 3155941 caattagcca gttctcccat ctttttttct ccttattaga taatatgcct gtgtcaattt 3156001 ctagtgatta tatcggcata aaaacagaat catttagctt ctgatcaagg taaaagatga 3156061 cactgaagcg gcttttcctt tttctaataa gcagcgggct gcgaagtgca aggtggcgcc 3156121 tgttgtataa agatcgtcta ttaaaatgat attcatacct tctgctgaat tattttttgt 3156181 atcaaaaatg cactctgaca gcaggcgttc tgttttcttt ttctttgact gtttctcatt 3156241 attcaggcga atgaggggat ggtgggaagg ccggtctaaa cattctgcca agagatgtgc 3156301 ctggttaaat ccgcgctctt cttcccgttc cttgctcagc ggaataggta caagaacaaa 3156361 atgcttatcg gggtaaacct tagaaaaggt tgaagaaaaa tcacttttaa atgcatttat 3156421 gatttctgca tctcctctaa atttaaaacg ggagagcgtt tctttcatca tatcattata 3156481 tgtgtaaact gaacggtttt gacgcaatag caaactgtct ctgatccttg ttctccacac 3156541 ctcgcaatcc ctgcatacgg catgaacaga ttgaggtctg ccgcacaggg ggcagatatg 3156601 tcctgtgatt ttctttaatt tgcttctgca agaataacaa accttttcat caggctttag 3156661 taaaaaaagg gctctccatg taacatcttg agaaaattgc gaatcacata ataaacagat 3156721 cagtttatga atgcctcctc ctgcttcgtt tgacataaat cgcttggact ctctgaaact 3156781 actgcagcag attcagccaa aatgacaagc attgctgtgt ttttttgttt atctaccagc 3156841 tcagctttcg tatatgcgat ctttttaaaa tcagtaacgt aggatggact cactttgttt 3156901 aaagaaagtg ccaatacatc gttttggcat acttggcaag tacaggccat atgaagctgg 3156961 tccatatatc ggtcgagcag ttctttcatt acgatttctt ttgaattgac aagcattttt 3157021 acagctcctc atcatcggtt atatgagtat actgtaccac gttttcaaat aatggctagt 3157081 ctgtacattc aacttttgct gccaattcat tcatttcttt tatatgcttt cttgcatcga 3157141 gcatactctt tgttttgccg aagtgaaagt aaatgacatc gccgtccgca tattctttat 3157201 gccggccggt tcttcctgca atttgaacaa gtgcgctttc cgtaaagata gacgattccg 3157261 ctcctagtac acccgtttgc accttgggga ctgtgacgcc tctttccagt attgttgttg 3157321 tgattaatag atcgagctga ccatctctga attgctgcac tttctccttt ctatgcttgt 3157381 cttccgcgtg cacagatgcg gttcggcaat gaacaccttt aaagcacgca gcagcctttt 3157441 ccagaataga aacggaagga acgaataaaa aaacaggcct cccttctttt acatgaaact 3157501 ctatccatct tttcaccgct ggcggaattt tatttcggtt taatttcttc ttccagtttc 3157561 cacaccatac aaagcgcggt tcgggtaaag gtttccggtg gtgtcttgcg gggatgcgaa 3157621 ctgaatgtaa ctgtccgttc agtgcttttc tttttaattc tttaggaggt gttgcactta 3157681 aataaacgag ggtgctgttt ttctttcttg ctttttgaac agcgaattga agggtttgat 3157741 cagcagaata tggaaaagcg tcaacttcat caatgatcat aacatcgatt gcatctttat 3157801 atcgcaaaag ctgatgcgta gtggaaatca taagcggaga tagccgccct ttgtcatcgc 3157861 ttcctccgta aagcgctgaa atgtcagcac cctgaaaggc agccttgagt cttggagcaa 3157921 gctctaatac aacatcggtg cgaggtgttg caatacatac acgcagtcct tgatttaacg 3157981 ctgattctat accaggaaac agcatttctg ttttgccagc gccgcaaacc gcccagatga 3158041 ggagctcttc tttttttgat attgcttcaa ttaaaacatt ggcggctttt tgctgtccgc 3158101 ttgaaagctt gccatcccat gtcagcttaa tagacttcca gtttgattca ttttcctctt 3158161 tccatgaata taaaggaacc tcctcactca ctctgcccat catgacacag gaacggcaat 3158221 acagcttatt ctttccagat gagtgataaa aagaaaaata ccgctgatca gtttgtccgc 3158281 acctattaca tctatatctc cgtttattta tggatataga attttcagca gtgatatatc 3158341 cattcttgat atgccattca atcatctcat cggaaaatga gagctcagtc ctgagcaaat 3158401 gacggcttcg aagcgtctgc tgcaattctt ttgaaaagga actgtttttt tcaactggca 3158461 cattcacata gcacgcctcc tttcgaaaca gtatgcctga atgaatattt tctgtccaac 3158521 tattaaaata agaatataaa aaaatctccg ctctaaaaac ggagatttgg ccttatttaa 3158581 aacaccagca aattcctaac gcaccttcac ccaaatgagt gccgattacc gcgccaaaat 3158641 agctgttata aaattcaaca tgaggatatt ttgcagaaag ctcttcaatg attttcgctg 3158701 cttcttcctc tcgattagcg tggataacag cagctcgcat aggcaaccct ttactcgcat 3158761 cttcgtctaa aagctcataa attcgcgaaa ttgctttttt acgtgtgcga atcttctcaa 3158821 aaggcacaat taccttattg tcaaaatgaa ggataggctt tacctttaga agactaccaa 3158881 tgaaggcttg ggcgctgctt aatcgcccgc cgcgctgaag atgggctaag tcatctacca 3158941 taaaataagc tcgaactgtt tttttcattt cttccagttc ttttataata tcttccggcg 3159001 atgatgctcc gtttttgatt aattcagcag ctttaagggc ataaaagcct tgagccaagc 3159061 agctgatctc tgagtcaaat ggatacacat caatattgtc gaccatcgaa tcagccgctg 3159121 ctgcactgct gaatgttccg ctgatcccgc tggaaagatg gatactgata accgcatcat 3159181 aagacttgcc aagctcttca tacaacgcaa ccagctcgcc gattggcggc tgagaagtcg 3159241 tcgggagctc attatgtttt ttcacttctt cataaaagct tttccagtcc aactcaattt 3159301 cttcacggta agtctcctcc ctaaaaacaa cctggagagg gatcatatgt atctgatgtt 3159361 gttcacgcat ttctttcgga atatatgccg tgctgtctgt tacgactgca atattcatag 3159421 cttcgatacc tgccttattg ctttataact ctattgtaag ggaaacggca gcctaaaaaa 3159481 agacctgcct agtaaaaggc aagtctccta ttatactatc tcatttctac ccagccattt 3159541 ttaatggcga ccacaacggc ttgcgtccgg tcgtttacat tcattttttg taaaatattg 3159601 ctgacatggt ttttaacggt tttctcactg ataaacaatg attcaccaat accgcggttg 3159661 ctttttccgt ctgcaagcat ctgcagcact tcacattccc gcctagttaa aatatgtaat 3159721 ggtctgcgga tttcagggta aacctcatgt tgagggtgtg cagaaactcc gcttgttgca 3159781 aggcggcgga attcgttaac gaggttgtga gtaaccttcg gatggaggta agatccgccc 3159841 tcagccacta ctttaaccgc ttcaattaat gtatcagcat ccatctcttt cagcagataa 3159901 cctcttgcac ctgttttcag ggcatgtgtt acataatttt cgtcatcgtg aattgataga 3159961 ataattactt tagattcagg atacagctct acaagctgtt ttgtagcttc cacaccattt 3160021 acgtttggca tattgatatc catgatcaca acatcaggat gatagtgctc aacaatacga 3160081 gccgcttcgt ccccgtcatc accttcggct accacttcaa aggtaggttc aaaatccaat 3160141 atccgtttaa caccttcacg aaataactga tggtcgtcga taataacaat gtttacttta 3160201 gtcacaagcc acgcctcctt gtattattgt tctatatact ctagcattcg gtcaatatgc 3160261 cttttggctc tattttacaa atcatagtca aagagataac ggaaccttaa tcataataaa 3160321 tgtcccaaga cctattttcg aatctattgt catcgttcct tccaataaat ctactctttc 3160381 tttcatgccc agcaagccga atgatttgtt tttcttctct ttcgcttcct tcaggtcgaa 3160441 ccctttaccg ttatctttta tcattaaaat cacaaaatcc tttgtgatct caactttgac 3160501 tgtaatttct tcagattcag aatgctttag cgcattagac acagcttcct gtgcgagcct 3160561 gaagagcgca acctcaaact gaggcgctag cctctgatcc tctgtttctc caatgcactg 3160621 aaaatgtatt ttgaccttcc cgttatattc ctcggttgta tatagatatt ttcttaaagt 3160681 tggaatcagg cctaggtcat caagggccat cggtcttaaa tcatatataa tccttctcac 3160741 ttcgtaaagg gcattccgaa cattttggcg gagattttta atttcttgga atccgtcctc 3160801 tgcgccccgg tcacggaaaa tccgctcgat taattccgat ctcatcataa cattcgccag 3160861 catttgagcg ggtccgtcat ggatttctct tgagactctt tttcgctctt cttcctgcgc 3160921 ctcaataatt cttaagccga aatcctgttt tgcctgagca tcagcaagaa gcagtccaac 3160981 ttcgcgcaaa tcctgattca agtagttgag cacaactgta atttggctta ctaatgattc 3161041 tgaccgctca atgatttcct gaagccctag caatctgcgc tccaaatcgt cccgccgttc 3161101 gcgcaattgc ttctcacgct gctggatcat cgtcaattct acctgcagct tatgggcttt 3161161 ttcataagca ttgcggattt cctcttcact gaatctatga aaattacggc tgacctcgga 3161221 taaacggttt ctcgcatggc gagtttgcac ttcaagttta tcgccaagct caatcacttc 3161281 atacacctgc tgtttaattt gtttcagttc ttcgaccagc tgttcatact gctggcgtga 3161341 ctgctccccg atttgaaaaa cctcgtcctt gctcccgtca acggttttca gcatcttcat 3161401 caaaatagaa tccagcactt tggaatccat ctttgtttta ttcataattt ccctccgtca 3161461 cggcgttgtc atatattttt attataaatg taattgatct gcaaattatg tcgaattata 3161521 atgaaagaat gcgtatattc tagaaaaaaa catttttata tactatctac tctttatgat 3161581 accaaaatac gcacaaaaat tctaaagact gtacgaattt gtataggcag tcttttatgc 3161641 ttagcaggag ggtcagctag catgctgcac agctatttta ctgtgaaaga agcgggagaa 3161701 cacgagattg ttatagaaaa atcgcgtttt atctgtcatt taagccgtgt ttctaccgaa 3161761 caagaggcac aggaatttat acagaaaata aagaaacagc actggaatgc gactcataat 3161821 tgctcggctt atgttattgg cgagaatgat catatccaaa aagccaatga tgacggggaa 3161881 ccaagcggta cagcgggagt gccgatgctc gaggttttaa aaaaacgcag gctgaaggat 3161941 acttgcgccg tcgttacacg ctacttcgga ggcattaagc ttggtgctgg cggattaatt 3162001 cgcgcttatg ggaaatcagt gtctgaagga ttaaatcata taggtgttgt agaacggaag 3162061 cttatgcgaa tcatgcatac ttctgcagat tacacatggc ttggcaagat tgaaaatgaa 3162121 ttaagggagt cacaatttct gttaaaggaa atccattatt cagaaaatgt tgaattcgaa 3162181 acatacgtgg aagaaaaaga aaccaacgct ttttctgaat ggatgacaga actgacaaat 3162241 ggaaagagtg atattaaaga gggagagttg acgtatcttg aaaaagccgt caatcacata 3162301 aaggagactg aataatggct gaacgcgtta gagtgcgtgt gcgaaaaaag aaaaagagca 3162361 aacgtaggaa aattttaaaa agaataatgt tattgttcgc ccttgcacta ttggtagttg 3162421 tagggcttgg cgggtataaa ctttataaaa ccattaacgc tgcggatgaa tcgtacgatg 3162481 ccctatcccg cgggaataaa tcaaatcttc gcaacgaagt tgtagacatg aagaaaaaac 3162541 cattttctat tttatttatg ggaatagagg attacgcgac taaaggacaa aaagggagat 3162601 cagactctct tattgttgtt accctggatc ccaaaaataa aaccatgaaa atgctgagca 3162661 ttccgcgtga cacacgtgtg caattagctg gtgacacaac gggaagcaag acgaagatca 3162721 atgccgctta cagcaaaggc ggtaaagatg aaacagttga aactgttgaa aacttcttgc 3162781 aaatcccgat cgataaatat gtcacagttg attttgacgg atttaaagat gtgattaatg 3162841 aagtcggcgg tattgatgtt gacgtgcctt tcgatttcga tgaaaaaagt gatgtagacg 3162901 aaagcaaacg gatttacttc aaaaaaggcg agatgcattt gaacggcgaa gaagccttag 3162961 catatgcccg gatgagaaaa caggataaac gcggagactt tggccgtaat gacagacaaa 3163021 aacaaatctt aaacgcgctg attgaccgca tgtcaagtgc aagcaacatt gctaaaattg 3163081 ataaaatcgc agaaaaagcc agcgaaaacg ttgaaaccaa tattcgcatt actgaaggtt 3163141 tagcgcttca gcagatttac agcggcttta ccagcaaaaa aatcgacaca ttgagcatta 3163201 caggttctga tttgtattta gggcctaaca acacatatta ctttgaacct gatgctacaa 3163261 atctcgagaa agtcagaaaa acgcttcaag agcatttaga ttatactcct gatacaagca 3163321 ctggcacttc cggtaccgaa gacgggactg acagctcaag cagttctggc agcactggca 3163381 gcactggcac aacaactgac gggacgacga acggaagcag ctattcgaat gacagcagca 3163441 caagctcaaa caacagtaca acgaattcaa caactgattc atcctattaa aaaatgcccg 3163501 gtccttttag aggatcgggc atttttgcgc agaaaaaaac tccggcacat aagccggagt 3163561 ttttaattcc ttttcaccag ccgtttataa aactttgtaa acggcttaaa tttttcattc 3163621 acgagtcctg tcacttctgc tatgatttgc ataaaaataa tcaaaatgaa gataataaac 3163681 aaagaaagcc aaattgtggc acttttaagt acaatcgcac tgatactgaa aataaatcca 3163741 attaaataaa taactaagac cgacatccga tgtgaaaggc caaaggccat cagtctatgg 3163801 tgaatatgcg acttatcagg cgctgaaatc ggctgtttgt ttaatattct tctgatgata 3163861 gcaaatgttg tatcaaaaat cggtacgcct aatataataa tcgggataac gatactgaac 3163921 aatgtgacac ttttatacag gcctaataat gaaagaatcg agatactata ccctaaaaac 3163981 agtgatcccg tatctcccat aaagattttt gccggatgga agttgtaaaa caaaaacccc 3164041 agcgtgctgg caataacgac taatgagagt gacagaatga gcacttttcc gccggatagc 3164101 gccatgacag caatcgttga caggccgata acagaaagac cggcagcaag gccatccaat 3164161 ccatcaatca ggttaattgc gttcgtgatg ccgacaatcc ataataccgt cagcggataa 3164221 gccatccatc ctaactcaaa tcgttctgtt aaaaaaggta ctgagaaaaa gtccattttt 3164281 aagccagtgc ttacaatcat aatggctaca cctaattgaa tcaaaaactt aacttttgca 3164341 cttaattgat atttatcgtc aagaatacct aacacaataa tgatgaatgc tccgactgta 3164401 attgccgtca tccttgtttc tgtgtaaata ccggatgcaa gcacgcctgc aaccaccccg 3164461 ataaatatgg ccagcccgcc catgcggggc atgattttgt catgtacttt tcgattgctg 3164521 ggctggtcaa ctgcacctat tttaatcgca atccttttta cgattggggt tatgattaaa 3164581 actgtcagca gcgagacaat aaacgcaaca acaatgcgaa tcatgcgttc gtcaagcata 3164641 aagaagtctc ctttggaatt aaatgaagtc tttatttata tagagaaccg ttccttccat 3164701 tataccttct ccttagttat tataacaagc ttcatcaaaa agaaacacgt ataatcaaaa 3164761 aacgcgcatc ccaatttata ggactacgca tgtttttgaa tccctgtata tttcataatt 3164821 tgtctaaata agcaattcca atcttgtgtc cgggcgatgt ttcggcgcat ttctttatag 3164881 gtctcgtctc cgttttgacc gagaactttt tcacaagcgg ctataaaatc aatcggatga 3164941 tcgccctcta catattcgta tacatacggc ttttgcattt ttgaggttga cggaagatta 3165001 gtgcctacaa caggttttcc tgccgctaaa aattcaaata gtttcagcgg aaacacagct 3165061 tgattatacg gtgattgttt atatggcata atgccaatgt cgataagctc catataatga 3165121 ggcacttctt ttggatctgc cggaccggtc catatgacat tgggaagcct cagcagctct 3165181 tgaaacgaaa catcaccatt ggtggcatcc gggccaaccc ataaaaatgt ccaatcaggc 3165241 ttttgcagtg ccgcttcttt aatcatttta aaatcgagct tcggtttaat cccgccaata 3165301 aaacctaaca ctattccttc tctcccctgc agtatactgc gatcgggagc ttgtttattt 3165361 gcagaaaaca gctcatactc cacaccgttt tccacagtat gaaccttttc tcgtcctgca 3165421 gtcagttttt tgtctacttc cttgtgaaga taatctgatg aacaggttat tgaatctgct 3165481 cgttgtataa ttctcagctc tgccgattta atgacttttc gccggaattc agacagcaga 3165541 tttgatcggc cgctgatcgg cgcagcccat aggtcactgc agtcataaat gacctgatcc 3165601 caagaataca gcgaagacag cagcgggaat ccgggaaacg tgtaccataa acagcagcgt 3165661 tcaccgtttg cagaagcagg tgtaagctca tcgagtaatg gggagagctt atgtctgtaa 3165721 aagacatctg tatatcgtcc gaaacgaaac atttttttct gcagcaggtc tttgacagcg 3165781 aattgcctga tgccagaatg gacttcctga aactctttcc cttgggcacg cggagccgga 3165841 catacccaaa taacttcctt cgtttcctcc tgagcagcta aaaattctgc cagccggtgc 3165901 cttctgtatc tcaattggtc ttttccccat tcagcagtgg caacgatgac atgaatgatt 3165961 gcttcttttg tttccacctt catcaccttt tctctctgtt tgcagctata atcttttttt 3166021 caccgcgttt tttgcatatt gaacaaaaca ccatgttgct ttcataaaat gaagccgttc 3166081 gatctccctg tagacaaacc acgttttttt cgcagccttc catttgttgc tggaaattga 3166141 attattgaca agccgatatt cagccaggca ttcattcatt ccataggcag taaatccttt 3166201 ttttaaaaga gacagccatg tggctaagtc ctgtctcgtt ctgatattcg gcatttggat 3166261 ctgtcccgtt tgctccctgt caatcatcac cgtcaagcag ccgataattg tatttttcag 3166321 ggcgtcatcg tacgtcaggc tttccggcgc atgaataaat ttatcgagcg gggtcccgtc 3166381 ctgcgccatt aagctgtagc ccgtgaaaga gaacgcacag gagcgctcca tcataaactc 3166441 aagctgcttt tccagtttgt cttttttcca tttgtcatca ctgtccaaaa atgctacgta 3166501 gcgcccttga gcgcgttcca acgctttgtt gcgagcaacc gcagctccgg agttctcttc 3166561 cagatacacc acatgaattc tttcgtctat tttttcatac tgctgtaaaa tgtcgcgggt 3166621 cccatccgtt gagcaatcat ccacgataat catttcccaa tgaggatggc tctgatctaa 3166681 taccgaatga accgtgtctt caatatagtc acgcgcatta taggaaggtg taatgacaga 3166741 tacgagaggt ttccaattgg tcatgatcac atctccatcg tatgatttta aaaggattct 3166801 ctgaaaaatt caggaatgac aacgaacata aaggcaatcg taaggccaat cataacgccg 3166861 agaactgctt tctttttcgg agacataccg ccgcctgctg tctcacttac ggtttcggaa 3166921 tcagtaacac ttgccgcttt caggttaagc tgtgtgtttt tgagttcata taaaaatctc 3166981 tctttatcca ctttggaatc ctcgctcacc gactcgcctt caagcgcgtc tatgctgctg 3167041 cggatgacgg cttctctttc tgcatacagc ttttgatcgt ttttgaggaa ggtggaggat 3167101 atggcgttta agacagattc cgttctatcc ttatcctcgt cactatagct taaagtcagt 3167161 aacgatttgg attccgtatt gattgtaagc ttctctttga tctctgctac atcttcatcc 3167221 ttttcatcag gaagcgcctc cttcaaaaag gagtcgctct ttaatagaag cggaatctct 3167281 tctgtgctgt tataaaccgg atgatcatag ctccccacag ccaaagtatc ttcagctgta 3167341 tagctctttt gatcagcgat ctgtgacggc aggatatacc ccgccgcacc taatataatt 3167401 ggcaccgcta tgatccaaat gatatttttt tttatgcgac gggctattct tatcaatata 3167461 tcgttcatat aagtctccct gctttttgta gtctgtttat ctgtacatcg gctcaggcat 3167521 ttgtctggat cgccttaaca cattcacggc ggcgatgacg agcgccataa acacccaatg 3167581 gaaaaataaa tttgaaacag agcttgggct gatacttgat accaggaaac tgaccatagc 3167641 ggtaataagt ccttctgtga tcagttttga ctgattttct aattttcttt cataaaactt 3167701 gtaaagcacc catatgaggt aggcataaac ggacaaatat cccagcatga tgaacaaacc 3167761 aaaattagca agaatttcaa caagccagtt atgcacctct gccacattgt cagtatcata 3167821 tacagcataa tgctcaagat aataggatac atttcctgcc ccgactccga atccgtatga 3167881 atcaaggaaa aaatgccaag cgtttttcag cagatttgcc cgagccacat ttgatggaag 3167941 cctgtcatga aatgaatgca gcgtctgcgg ggccagaaac agctcccaaa actttgaata 3168001 gattttgctg gcgaaaagaa ctgcgaaaag agcaattccc gccgccgaca gccatatagc 3168061 cattctcttt aaaacaggcg gcaatacaat gaagatgtag acagcaatac ctgcaaaaat 3168121 gcccagaagg ctggctcttg aaccagtggc aaaaattaaa tacaacgcac agagcgagag 3168181 cacaaggcca attgccttga tgtatccatt cttaatgttt ttcatcatcg tgatgtaaaa 3168241 aaagaagctg atggataaaa aggtcgcaaa gtcattttga ttaaaaaaga ccgatgtcgg 3168301 ataatgctgc ttgtactccg gtccgctgta caatgtggaa ctcgcaagat gatggtgggt 3168361 gatatgattg taaaaaccaa tgatcatcag aaataccgtc atcaccagcc aaatggcata 3168421 aacaatcatc agccgctcca ttttttgcac gtacatgaca ataagataaa tgaagaagat 3168481 ccccattgcc aataaggcta aatacttgag gccaactgtt accgacttgg cccacagcag 3168541 agaaacaagg ccatatataa accaaaaggc gaaaaagagt aaaatccctt ttacttgcag 3168601 cccatgccat ctttcaatat gggttcgatt ccgaaccatg ccgaaaatat gaaggcaacc 3168661 cgctgcaatg agcagaagcc ggtaaaggaa caaactgaaa aatccaagat gaatggcaaa 3168721 aaatgcatta tttaaaaaag tgcaggcgat caaaatatag attacagcca taaagagccg 3168781 ttcttttgtt gtaaatgcgg ttgcaagcgt cagtaaaaac aggccaattg ccaacaccgc 3168841 aagcacagca gccatctgca tgaaacctat atctttatgg atggctccca gcaataggac 3168901 gactccaaat atagcagcgg ccagtaacgc tagcgtatgg accgctgatc gtttgatact 3168961 cacatgttta acccctttcc tgatgtttca ggagccggcg gccgagccta gcagccggca 3169021 gcttcaacca agtaacactt tttcttttta taaattgacg cttcccaagt ctttagccaa 3169081 ttcttcaagc ggcaagcccg gaaaatactt gtcagagggt tccgttcccc gaacagcggg 3169141 acggccgata gagtgataaa tgtatccggc tgcctgcatc tcttcaagtg aaaataaatt 3169201 tctgccgtca atgatgactg gctgttttaa gagggttttc acttttacaa gctccatttc 3169261 tttcacttcc ggccaatccg ttaaaatcag gcatgcatca gtgtcttcca tcgcagcata 3169321 cacatctgtg taatactcga cctgttcgcc aaggatcgct gaagcttcag gaatagcaat 3169381 cggatcgtat gcttttacat gggcgcccag ctgctgcagc attgggataa tatcaagcgc 3169441 tggagcggat ctcacatcgt tcgtattcgg tttgaaggct aatcccagga ctgaaatggt 3169501 tctccctttg acgcttccca taacagtcaa aagtttatct acaatatgaa cacgctgctt 3169561 ttcgttcgtt tcaatgacag cttcgatgag cttgaatgga tagcctgccg attttgcgat 3169621 ttgaagcagc gcggttgtat cctttggaaa acatgaaccg ccgaatccaa taccagcttt 3169681 aaggaacttt ctgccgatac ggctgtcaag accaacacca tcagcaactt ttgaaacgtc 3169741 tgcgccgact cgctcacaaa tgtttgcgat atcgttgata aaggaaatct ttgtcgccag 3169801 aaatgcattc gcggcgtatt taatcatttc tgcactttct aggtttgttt taatgacagg 3169861 agcatggaat ggctgatgaa gttcctcaat gatggcagcg gctttatgac ttgttgaacc 3169921 aatcacggca cgctccatat tcatcgtgtc atgaatcgct gacccttccc gaaggaattc 3169981 agggttagat acaacatcaa atgagtatct cccctttgag gctttttgaa cgatagattg 3170041 caccagtttc cctgttccaa ccgggactgt gcttttattt acgatcactt tgtagccgtt 3170101 aagatgctca ccgattgttt tcgccgccgc tttgacgtac gttaaatcag cttcacctgt 3170161 tttggacata ggcgttccga ctgcaatata aataatatct gaggcccgaa tggcagacgg 3170221 gatatcgttc gtaaaggtca ggcgctgatc cagcacattt ttttcaacta agtctgcaag 3170281 ccctggttca tagattggga ttaccccatt tttcaggctt ctgatttttg attcatcgat 3170341 atcacagcaa acaactttat tgccgatctc cgcaaagcaa gtgcctgata cgagtcctac 3170401 ataacctgtt ccaatgacag ctattttttt cacagcgctc aaccctctcc tgtaaaatga 3170461 tcttccaatt tataatggtc gcagtgtctt acgattaaac ggacgttttc gtgaccgtct 3170521 gatactgatg atgcaaggcc ttggcgtttt ttcctgcgtc aaattgagcc tgcacggttt 3170581 catacaagtc atctgctact tccggcttcc atatttgctc atgttcgtac cgagtgatcg 3170641 cttccgccaa ggcttgagcg gatttcggtt taatcagcag atgttggtgc tttccgaata 3170701 aagacgacac tccgccaaca tccgtacaaa taacaggaac ccttagcgcc agcgcctcaa 3170761 tcacaacagt cggcatcccc tcactgtaag aaggaagtac gaatagatct gccgcaagta 3170821 aatagtctct tacctgatga ttcgggactt ggcctgtgac gatatgcccc ttctgcgtca 3170881 gcgtcgattt tgcgggacca tccccgacaa agactgcctt aggagagtcc tgcagcgatt 3170941 cgatcgcttc agacagttca aaaatgcctt tctctctgac cagccggccg acatagacag 3171001 ccagacgctg atcgagcggg agtccgagtc tttttctgat ttcctctttc gtctcctcat 3171061 tcccctgaaa acggctgagc tgtatgccga ttggcaaaac cgagctgtca aagcccgaaa 3171121 gctttttggc ttcttcctga agcttgtggc tgactgctaa aacaactgac gcagaaccta 3171181 cggcacgctt gaaggcttta aacgcacctt tgctgtaatg cggatagaca ttcacatcac 3171241 tgccatgcaa ggtcaggaca taaggaattt gcgctgactc tgacacgact gccgcagccc 3171301 cgcccgatgg catggcaaaa tgcgcatgga tcagatccgg atataggtcg cgctgtttca 3171361 ttgtttttaa aacggctgat gcgattctcc gatgaggctg cgcccacttc agctggccgg 3171421 gaactgcccg atagaaaggc cggtaaaccg gtatcccctt tctaatctca tactccggtc 3171481 tgacatcctt ttttcgatat gtctttttca gcatgcggac aggtgctgaa tgaaaaggcc 3171541 gtgggcatat cacagtgata tcaagcccga gtttttgcag ctcttgcacc tgtgtctcat 3171601 gaaacacacc ctctccgggt ttcatactgc tcggatatac gcttgtgatc cacaaaatct 3171661 tcatgacaaa cgtccttttc ttagtagttt gcttttcgtt tgagggtacg cttttaccaa 3171721 aagaaagaga tagcacagcg ccccagccgc aactgaaatg gccagccgca tttctgcctg 3171781 catactgaag tgttcggtac tgaggcttac accaaacgcg atgatgccca tcgccgcagt 3171841 aatcagaaat ggcttcataa tcgactggaa ataagctgaa aggttaagct tgatgacata 3171901 tgccaaaagc cagcgcccaa tcaggaaatt aacaacgctg ataatggcat acacccatgc 3171961 gactgtcagc aggcttcccg tctgtacagc tgcaaacagt gataatccgt acagcagcag 3172021 cacgccggaa tcccaataaa acgctaagtc agctcttcct ttagccagca acacagatcc 3172081 atttggattc atgagcactc ttagtattcc gacaatcgca agaacattta ggatcggaac 3172141 agcagcaagc catttttctc cgaaaaccgc tgtgataaag gcgtctgaca cagacacgag 3172201 cccgattaac agcggaaacg aaacaagcgc cagcattttt gtcatattca gaaagccttc 3172261 tctgatcacg ctgttttcat atttgttttt tgcgaaaata gggaatgcca cccgtgtgac 3172321 aatcggattg atcttcaaaa ccggaatggt gacaatctga taagcgaggt tataaatccc 3172381 caatgcttca gcaccaataa accggccgat caaaatcatg tcgatatttg ctcccagcct 3172441 gttcacaaga cgggatgaaa gctgaaaggc tccaaaagaa aagaaatcct tcatgcctct 3172501 caaatcaaaa acaaaagcag gatgccactt ttttcggtat acagcccaat ataaaatccc 3172561 tttactggac tgcagcagga cttgagaaat cacgtacgcc aaaatcgcat ccatcataaa 3172621 aaccgctatc gctaaatatc cgaatgacaa tacatttgaa aaaatctcta ttttgcttaa 3172681 cgtattaaaa tgcagctgct tttgcagcat atactgatat tgctgtccaa ttggcgcgat 3172741 caaaaacata atcgccagaa tccgaaccag aaacaccagc tcttctcttt gataaaatcc 3172801 cgcaatgaca ggactgctca catataaaag aacaaacagc aaaacgcccg tcataatgtt 3172861 aagccaatac aatgttgaca gctggcgctc cgtcgcgtcg tctctctgaa ttaatgctgc 3172921 gccaaaaccc atatcgagca caatctgggc gaaaactgta accgttgtga tcatgccgac 3172981 aagcccaaat tctgttaagg tcatcatatt tccaagcagg gcaaactgaa caatttgtat 3173041 gattgtaata cacatggttg aaatacttgt ccactttgca ccgctcatga tttgttttgt 3173101 aatacttggc atcatattcc ctacttcttt ttaagctcag attgatggtg aataatggaa 3173161 tcccgtttta tcttgcacca tcacccgtcc aaactacttt acaagttttt aacataattt 3173221 ttaattctaa agtgaaagtc agattgcgaa tgtaatataa atcaaatatc agcttttcct 3173281 tcggcgtcat atcgtaaccg ccgttcacct gagcccagac gctgtgtaaa gcctggaatc 3173341 tcattctgga atttttccgt aaatacgggc cgttccggac gagggccaat catactcata 3173401 tcgcctttca gcacattaaa cagctgagga agctcgtcaa ttctcgttct tctgataaaa 3173461 gctccgatcc ttgtcacccg cggatcttgc ttctgtgccc aaaccgcccc agacttctcg 3173521 gcatctattt tcatggaacg aagcttataa agcttaaatg gcttcccgcc tttccctacg 3173581 cgttcctgcg tataaatggc aggccccggc gtctccaaac aaatcaaaat tgaaaatacc 3173641 gcaatcattg gcagcgcaat cgccaatcca atgagcgcaa accaaatatc cattacgcgc 3173701 tttattgcca aataacgagc cgtcttttca gataatgtaa aagaatgtat ttgttgaact 3173761 gagaattcac gactcacatt catgcttttc tctgcactca ctgacacaca cctcacgatt 3173821 tgtttgggat gttatgatga cctatgccag tcagtttagc agacggatgt taattggatg 3173881 taaatggtat gttaagaagt gtgaattacg tgttttttct gataaatgtt gttaatactc 3173941 ttttactatt ttatatacaa gtcctatttg ttttaatcat ttcatataaa aaagagacaa 3174001 atctgtgatt agatttgtct ctttcgatta tctgtaataa gatactgtgc cgtcatgaat 3174061 agcttgtgca gctttatctt tataaaccgc ttgcttcaat ttacttgcat ctgatgcatt 3174121 agtgataaag gcagtttcaa ctaaaacact cggcatttta gaatatttaa taacatagaa 3174181 agcagctgtt tttactcccc ggtctctcgt tccaagatta gccgctaact ttggttgaat 3174241 ttgttcagcc agtctcttgc tatttgcagc ttgatatgtt gtatcgtagt acgtctcact 3174301 tccatttggt gatgagctat cattagcatt tgcatgtata ctgagaaata aatctgcttg 3174361 tgcagaagct gctttattta ctctctcctg taaagaataa aaagtatcat tagatcttga 3174421 cagtactgga agagcacctg aagcatttag ctttgtattg actcttttcg ctatatcaag 3174481 gttgacttct ttctcaagga gtccattgcc gattgctcct gaatcttgat caccgtgacc 3174541 cggatcaata aagattgttt cacctacaac tggattcttt agctgattag caacctttgt 3174601 gcttacggca ggagtgtttc cgataatcat aaagtttgac atgtttttac ttccaataat 3174661 tttacgggct cctgtagata aattttcacc atttgtaaga ataagagatt gcttcttctt 3174721 agctgccagt gtagctcctg caatagagtc agggtagctg aatccattgc ttacatatac 3174781 ggtgcttgtt gataaattaa gtttttgtac gatatttgca gcaagctcat atctgtttga 3174841 accgctaatt cttgtaggag aaggtaactt gttgtatacc gtattgctga tacttccagt 3174901 gcctcctaca acaacggtac tcgaaattcc cttatctttt atcacagacg tagtcgcact 3174961 atttatagat gttttatttg taaaaagaat tggatacccg tttttcgctg cataagggat 3175021 gacggccgga gcgtctgcat ataagaagcc gttcaaaata acagcttttg aagtcgcacc 3175081 catcgctttt gccacccgtg cagccgtatc ataacggttg cttcctgcaa ttcgtttaat 3175141 acttatcccc aagcttttaa tctggttagc agtgttagaa gaaacagcag gtgttccgcc 3175201 tacaataatt acatttttag tctgcatctc tttcaatctt gttttcgttt catatgaaag 3175261 cttatcagaa ttagtgtaaa gcaatggcgc attcttctgg taagcaagag gtgctgctga 3175321 aatagcatct gcataggaac tcccaccaac aattacagct gtacttgctg ttgaatacat 3175381 ttgctttgat atttgtacag cagtgccgta tctattgctt cccccaactc ttttcactga 3175441 gttatcggcc aaagctgttg gcacaaaaag tatgagcccc agaaaacaca ttgttaggac 3175501 ttttatataa gaacgcaatt gatttcctcc ttaaatggcg ttatatccta aaataatcaa 3175561 taacttgtca gagttgtacc tggatagtaa aatttcaaaa ttgaactata tgaatctcca 3175621 gcttctgctc ttgcttttgc tccatattga ctcattccga tcccgtgacc atatccttta 3175681 ccgctgattg tgtactttga agtatctttt tttacagtca cataagtact tttaaataca 3175741 gtcgctccaa tcattgttct taactcactt gttggtacac taatggttgt aattttgctc 3175801 aagttatagg agccagtact gcttttaaca aaatacttca ctttcatcga tgctgttttt 3175861 gcacgctgcc cttgtgtcgt tccactaaag cttaaatcgt caatacttgc aattttgaca 3175921 gaatcagcgc ttgtttcttt atttttcaag atccagttct taactccgga aagtcttgca 3175981 gaatcagttt cagtcgctga agaccaccaa gaagaaggct tcgttaagtc caaagatttc 3176041 gtatctagct gttgttttga caaagtaagc gtccagccta tttgaggatc ctttgtatct 3176101 ttttttgcaa tcaagtaagg tacacttgac gaccacactt cattactagc ttctgtgtaa 3176161 ccaccattac tggaagaata agctgcagtt ataagagatc cattatattt cagaactttc 3176221 cccttcgttt gctctaccgc tttattggta ttcgaattcc aactgtagcc accataaact 3176281 tgaaaagcgg ttgtatcagg tacagtagtt cctgtttttg ttattgagta ggttcttgca 3176341 gcgacagtct gtgctttaag agcctcaagt gaccagctag caggcatttc attcggaatt 3176401 actcctttta agtaatcctc aaatggaata ttctcattta ccggtcggat atatttagta 3176461 gactcaatag agaaattaac cgtgccaaga tactgctttc catcaagact aattctgttt 3176521 gaagtagaat agttttctgg tttaattctt agggagtttc cgtaagtttt gatgttttca 3176581 aggtttaatt ttccgctgtt gatttttaga ttataggtgc caccgtcagc taaataaaat 3176641 tcatcagcaa gtgaattctc aacttcagca gaaattgaac tggtacttcc aataaagtcg 3176701 tatgcatatg tggctttatc tttcgttata cttttagccg cagccggaac gctatcttgt 3176761 ttaacaaata aaatttggct gtttttcttc gaggcaagcg aagcgcctat caatacgtct 3176821 gcatattttg tcccgttcgt cattacgact ttatcagcct tcaactttag ttgcttaatt 3176881 atatttgccg taagttcata tctggttgat ccaggaatcc tttgcacagt tgaagttttt 3176941 ttaatttggt tttctacact atcactgacg ctaaatgaac tgcctataat gatgacttgt 3177001 tttggcaaat cataatccgg aagcttgtct ttctctgtaa gcaaaatagg gtatccgtgt 3177061 gctgctgcat atggagcaat ggctaaagcg tcttgaaata ctcttccggt tacaacgatc 3177121 gctttatcat agctgcccat ttgctttgca atattttctg ataagacata tctatttttt 3177181 ccgcttatcc ttttcacagc gccatatgat ttcagcttgt tttctacgtc ttttgaaatg 3177241 cttcgcgctc ccccaatgat taaaatatta tcagggttaa acttagcaat ttgtctttca 3177301 gtagtttttg ttaacgtgtc aggctgagta aataaaactg gtgcgttcag ttttttcgcc 3177361 aatggaataa caggcaatgc atcaataaaa atatctcggt tcaccaatat cactgtatta 3177421 ggatttttcc actggctgtt ggatgcaaga gtcgcagttt cgtatcgtga agcgcctgca 3177481 aaacgatccg taacagcaac attatctcca gttactttat aaaatcctgt tggcgataga 3177541 ctgatgctag atttatttcc aatataattt aacaatttaa ctgagatgtt tgagtctgct 3177601 gcaaaagaaa ctgatggaat caataataag attgcagcaa gtgaacacac tatcaattgt 3177661 ttgcaagatt tcaaaatttc aggttcctcc ctatatctta gttggcacgt tcaatatctt 3177721 ttaacagaag ctgaccctca tcattttttt catatgtaat cgtgacctta tctccactgt 3177781 taaacttatc aagatcactt gtcgattctt cagtgatatc aagactaacc ggctcattat 3177841 ctactgttac ttctattgta tgagtatcag ctaaccctac ataagtacct tcttttgttt 3177901 caatgttact gtctggcgat acatcttcac cttgactctt ttgactatta accccgcaac 3177961 ccgaaagaag caatataaag aacagtaaag caataaattt tttcattttt ttcacctcat 3178021 tatattttat cgtcaaccta ttttatattt taaagaaaaa ttaagaaaca atgaaacttt 3178081 tttttataaa aaacgactat tttaggattt cattcttgta ttaaatagag ttgtatttat 3178141 tggaaattta actcataatg aaagtaattt aacagacgag gtgcaaagga tgagaaacga 3178201 acgcagaaaa aagaaaaaaa ctttattact gacaatttta acgataatcg gacttcttgt 3178261 actcggaact ggcggctatg catactactt atggcataaa gcagcttcaa ccgtggcaag 3178321 tattcatgaa agcattgata aatctaaaaa gagggataaa gaggtcagta tcaataaaaa 3178381 agatcctttt tccgtcttaa tcatgggtgt ggatgaacgc gacggcgata agggccgtgc 3178441 cgatacgctc atttatatga ccgttaaccc aaaaacgaat acaaccgaca tggtcagcat 3178501 tccgcgtgac acgtatacaa aaattatcgg aaaaggcaca atggataaaa tcaaccattc 3178561 atacgctttc ggcggcacac agatgacggt agacactgtt gagaacttcc tcgatgttcc 3178621 ggttgattat tttgtgaaag tgaacatgga aagctttaga gacgttgttg atacacttgg 3178681 cggcattaca gttaacagca cattcgcgtt cagttatgac ggttattcgt tcggcaaagg 3178741 agaaatcacg ctgaacggaa aagaagcgct cgcttatacc cggatgagaa aagaagatcc 3178801 gagaggcgac ttcggacgcc aggaccgcca gcgccaagtc atccaaggta ttattaataa 3178861 aggcgctaat atttcttcca tcacgaaatt cggagatatg tttaaagttg ttgaaaataa 3178921 tgtgaaaacg aacttgacct tcgataacat gtgggatatc cagtccgatt acaaaggtgc 3178981 gcggaaacat attaaacagc acgaactaaa aggtacaggc acgaaaatca atggaattta 3179041 ctactaccaa gctgatgaaa gcgccctttc cgatattaca aaagagctga aggaaagcct 3179101 cgaaaagtaa aacaaaaaga agcttcgcac aatgtgcaaa gcttcttttt tatttgcctg 3179161 taaatgaatc cggttgttct tttcgatacc cgtaatgaaa cagcaattct tccacaatcc 3179221 ggcgggaagc ctctccatct ccatacggat tagaagcctg ggacattttc ttgtactcat 3179281 caggatcagt taacagctgt tttgcaagct gataaatgtt ttcctcatcc gtacctgcaa 3179341 gtttcagcgt tcccgcttcc actccttcag gccgttccgt cgtatcacgc agaacaagaa 3179401 ccggtttccc gagagatggg gcttcctcct gcacgccgcc cgaatcggtc aatataaaat 3179461 gcgatttcgc tgcaaagtta tggaaatcga tcacctctaa aggttcaatc agatgcactc 3179521 tgtcagaatc accaaaatgc ttatgagccg cttcccggac aacaggattc aggtgcacag 3179581 ggtaaacgac ttgtacatct tcaaattccc ctacaattct gcggatggcc ttaaacatgt 3179641 tttccattgg ctcacccaaa ttttcccggc ggtgagcggt caagagaatc attttatcct 3179701 cacccacctg atcgagaaca ggatgtgagt aaccatccct aaccgttgtg ttgagtgcgt 3179761 caatcgctgt attgcccgtt acaaaaatag agtcggcctt tttgttttct tttaataaat 3179821 tgtctttcgc ctggcctgtc ggagcaaaat gcaaatcagc aatcgcccct gtcatctgtc 3179881 gattgagctc ttccggaaac ggggaatact tattccctgt acggagcccc gcctccacat 3179941 gaccgacagc aatttgatgg taaaaagcgg ctaggcttcc ggcaaacgtc gtcgtcgtat 3180001 caccatggac aagcacaata tcgggtttga tatctttaaa caactcatcc aatcttacaa 3180061 gtgcgttaga cgtaatctct gccagtgtct gccgctcctt cataatgttc aaatcgaagt 3180121 caggcttgat gtgaaacgca tctaacacct gatcgagcat ctgtctgtgc tgtgcagtta 3180181 ccgttacata ggaatctatt tcaggatatt ttttcaattc aagcacaagc ggtgccatct 3180241 tgatcgcttc aggcctggtc ccgaaaacgg tcatcacttt tagttttttc atatttgtca 3180301 cctggttttc tgctatagta aataaattca tactacatat tctacatgaa aatgcatcat 3180361 tttaaatcat ttcattcttg attcaaataa aatgatataa gttttaatat taaggataaa 3180421 gcttgtttaa aaatggttta tccgatatca taaaaatgtg taaaaacata ttgaaaaggg 3180481 taaatagaga atagtttaac cataaatttt ttcgatcata aggaaggtgc cttttaaatg 3180541 aaaaaagtac gtaaagccat aattccagca gcaggcttag gaacacgttt tcttccggct 3180601 acgaaagcaa tgccgaaaga aatgcttcct atcgttgata aacctaccat tcaatacata 3180661 attgaagaag ctgttgaagc cggtattgaa gatattatta tcgtaacagg aaaaagcaag 3180721 cgtgcgattg aggatcattt tgattactct cctgagcttg aaagaaacct agaagaaaaa 3180781 ggaaaaactg agctgcttga aaaagtgaaa aaggcttcta acctggctga cattcactat 3180841 atccgccaaa aagaacctaa aggtctcgga catgctgtct ggtgcgcacg caactttatc 3180901 ggcgatgagc cgtttgcggt actgcttggt gacgatattg ttcaggctga aactccaggg 3180961 ttgcgccaat taatggatga atatgaaaaa acactttctt ctattatcgg tgttcagcag 3181021 gtgcccgaag aagaaacaca ccgctacggc attattgacc cgctgacaag tgaaggccgc 3181081 cgttatcagg tgaaaaactt cgttgaaaaa ccgcctaaag gcacagcacc ttctaatctt 3181141 gccatcttag gccgttacgt attcacgcct gagatcttca tgtatttaga agagcagcag 3181201 gttggcgccg gcggagaaat tcagctcaca gacgccattc aaaagctgaa tgaaattcaa 3181261 agagtgtttg cttacgattt tgaaggcaag cgttatgatg ttggtgaaaa gctcggcttt 3181321 atcacaacaa ctcttgaatt tgcgatgcag gataaagagc ttcgcgatca gctcgttcca 3181381 tttatggaag gtttactaaa caaagaagaa atctaaacaa aaaggctatt ggacattcat 3181441 ccaatagcct ttttttattt caacatcaaa gtcaatgtat gctcttcatt atcaactgcg 3181501 aagacctgat caacggcctg ccgcaaaaat taataatccc agacaaacac actgattgta 3181561 gagttaaaca aactaaatga aaacataaat acaaacatgc agattaaata gtaaatatct 3181621 tgtattcaat gcaagctaag taaacaccac ttgctaaaag aacaatgact aaacaaccag 3181681 cattacaaaa taattaaata aatttgaagc aattacaaca gaaggcagtg aactgtcgga 3181741 aagttcattt tggctaccat attaatccct ttaactacgc tgttggattt atcaagaatt 3181801 gtcgggctaa tagaaaacca cggaatcaaa ccagccagca ttcaaacgat aaaaggcact 3181861 tctccgatac ctgttatgac cagcttactg ttgcgcatcc caaatacaaa ccagtacgcc 3181921 atcattagaa taaggggatt taaaacctgc cataatacac caaaataatt gattttttgg 3181981 atctttcggt taaagaaatt taaaagtacc agtgaatatt gtaacaaatg ttgagttttt 3182041 ttcactttta aaaagtaaag agaagtctcg cagaacttct cccaacattt gaagtgtcaa 3182101 tataaaacaa accaacctca tttagcaact ttattattat ctaattccaa aatagcatta 3182161 taaatacgat tcctattatt tttatcagta tatgcaaaaa agttatctac tctttttcta 3182221 tacttatctt ccatacgact attgtttttc atataataga taactttatc cactaagcta 3182281 ttatgatttt ctaatacatc accaaacccc atttttttat aatcataata atcaagttta 3182341 aaatggtatg acttttcgta ttgataataa ataacaggtt ttttctcata tgcaaaatca 3182401 aacgcaacag atgaaaaatc agtaatcatt atattagaag aattaaatag catttgatag 3182461 ctgctgttat agtcggcaaa ctccacataa tcatgctttt caaagtctac aatctgttgc 3182521 tgaatatctg ggtgaggaaa aaaagttatt ttataattat ttttcttagc aaattcgatt 3182581 agccgttcat cattaatcaa agcattatac ctagaaaaat attcactatc tttaaatttc 3182641 gggttgtacg gtcttactcc ttttgcctga tctttcggta atacaatatc ttttctccaa 3182701 gtcggcatta ttagaagttg cttttctccc tcactcttct taagattatc gtatctcgga 3182761 aatccaccca acaaaatatt ctctttttta tagttgtaat tccctttcac aatagaccga 3182821 tattcaggtt tggcagaagt gactaataat ttgatattct tgttgtattt gtttaaccat 3182881 tcagaatgat ctgccattgt tattccgtgc tgtaaaaaga taaactcaaa gttaaataaa 3182941 tctctaaaat aaatctccat attaaaaaat ggatttacaa cccatatatc tgcatgtgtc 3183001 gatattactt tggaagagga taaggttaaa attttatgtc taaaagatct gtatggtatg 3183061 acctttccat attttttgat tctgtcgtaa tccttgctat ctttttttat tataaagtat 3183121 ttttttaccc catcattctt gttgattgca tatttaaaga ggtgctcggc attatcatca 3183181 gctttgtctt gtctgtctat gaataaccat actggttttc tattaaaaat agtgaaaaca 3183241 tggtgtacca ttcttgccat cagtgccttc ttaatcgctg attttcgttt ttttgatttt 3183301 tcccctgatt tatgtaggga ttttaagaaa cgaaactctt ttataaatct atttttaaaa 3183361 ttgttttttt tgaacattaa ttttttataa ttataataaa aaatataatc ttttttagcc 3183421 acataagtat tatataaatc gtttgacaaa cctgaatact tgaaaaaacg aagttttgtc 3183481 aacttccttt ttttaccctt agttataaaa aactcaatat gatgattatc tgctagatga 3183541 cctttgggaa tatctattga aaaaccggga tattttttta ttacttctcc taaacttata 3183601 taatcattat gctgtctttt tatattcttt gcttttattt ttgtttcgcc aattttagca 3183661 taaaacttaa aacctttaga attaaacagc gagctccaaa agccttctat gtgaatggaa 3183721 tcctcatttt cttctaaaat ttcaatagtt aaagtttgat ccgataattt cgaaacaatt 3183781 ttaccttctc tgtataaata ataatcctgt tcagtttctc tttcatatac atacctacta 3183841 taattttcac cgtgctttat ttttaaagca tgatataaat agaaatggct gacacttttt 3183901 gtttcaatga tgacatcgtc gtcaatatac gacaatactt ctcgaatcaa tgttaaaaat 3183961 tcactgtatt cattttcgtc taaaggtgtt tcactgatat ccttaatcaa taatttccac 3184021 ttcaaatcat gcataaccat atattgaaga aataaaggta ttttctgttc atgatttttt 3184081 ataatatcga ttaaattctt tgagaaagtg ataagtgaat ggttaaacca attcttattt 3184141 gctttagcag tctgcatggc agatgatcca tcttctctaa ctctataatg gtattttgcc 3184201 tctttaacca gaccatactt tttcttttgc gatatgatta aattaactag tttggcatct 3184261 tcacctattt tacaattttc atcaaacctg atatttttca aggcatcttt ttttataaat 3184321 gtagaacaac aatgagttaa tatatgatgc ggttcttttt ctacatccaa aattcttgta 3184381 gaagaaaact tattatttag attatgttct ccagttcttc cttctgcaaa aaaaataggg 3184441 attgctacaa tatcaatttc attcttatgt tcgtcaaaga agtttaaaac attttcgaat 3184501 gttccttctg aaactaaatc atccggatcc aaaaattgaa tatatctacc ttcagcatac 3184561 tttaaaccat aatttcgagc actgctcact ccgccattct gtttctttgc atagacaatg 3184621 ttattgggat atttctgagc atattcttta caaatgattt cacttttatc ggggctatca 3184681 tcattcacca gtattaactg aatattctca aaaccaatag tttggttaat gatactttct 3184741 atagcttcag tgagatacaa ctcaacatta taaatcggca ttataacact gaaatcatag 3184801 ttaaaacttt tttcgttcat aaaagattac tcctaacata atgtttatat gaataagaat 3184861 tcgggtaaat aaaattaaga aacaagagag tactaatttt tgcaaaacaa ttttaattta 3184921 gtaaaatgta tgaaaagcat tccttacctt tttttaaaaa cccttgtaag caaactttta 3184981 aaaatgttca catggttaag ttctaaagaa tcatttggtg tttttagtac aaagtcaaat 3185041 gcaaaggccc aaatcggtat ttcgacaaca aaaccagcat atctaaaatc tcttaattta 3185101 tatccccata cttcaattgt ttttttcagt tcttttcgtt tgcatttttt taatctttta 3185161 aaatatttta tatatattct gtcattttct ttcatctcat aatactggtt aataaagtgc 3185221 cctgttaatt caagtctaag cccttttatt tttgccgaag taacagtaca tgaactatgc 3185281 agtactcttt ctttttttat attttcaaga gcttctgtat tttcttttaa taagtgaaac 3185341 ataaattctt tatagtacat cggcatatct tgttctttta taaattgcgg gtcaataaat 3185401 tttaaaactt taataaaatc atcaacaaaa actctttgtt cttgttgatc taaaacagac 3185461 ttataaacat ctctatagtt cggatataaa aacagtttta tatgatatac aattaaaaat 3185521 tgcaaataag gcaaaactat atcatatttg ttgaatgaat ccatcaacaa agtcatgtaa 3185581 cattcattca acaaatatgt gtaccttttt ttgttaaacc atgaacgatc aactaaagaa 3185641 tcctgttctt tccgttttct ataaaaatac tttccttctg caactgctcc gtatcttttt 3185701 tctttcagta ataactggtt aaaaaagata gcgtcttccc aaaactttat agattcatca 3185761 aaaaggacgg tactagttag tgtatgtctt ctgtaaaaag tgccgccaat ataaaaatga 3185821 atagctttat aatcgttgag aatatttata actcttgttc ctttttcaaa tctattattt 3185881 aatttatgtc ccccttcttt ttcacctgtg taataaacag gtaataccgc aatatttaca 3185941 tgttcggaat cacaaaaaaa atcataaaca ctttgcagcg cattttgaga gaatgcatcg 3186001 tcagaatcaa gaaaaccaat aaatttagat ctttcgctta catttgataa tccacaattt 3186061 cttgcagcag aaggtccaga gttttcaatt ttcatgattt taatattatt aggatataga 3186121 tttttaaagg attcacaaat ttgaggactg ctgtcaacac taccatcatc tattaatatc 3186181 agttctatat tttccttaaa tccaattgac tggttaagga cactctctat tgaatatctt 3186241 aaataatttt cagaattata tattggtata attatagaaa acatgtttgt acctctttat 3186301 ttagaagtta aaggatcgtt tcaattactc ttttagaagc cttgcctctt ctaaattaca 3186361 aaatttatta taaaaatcct catagttatg atctatataa ggattatgta acaactcttt 3186421 taccgtatct ataagttctt cacttgtttg aagcaagttt cctggcgttt tttgctgaaa 3186481 attaaagtaa aaacctctga tacagtctct ataagccggg agatcataca caaaaaatac 3186541 aaggtttttt taaaaattca tattatcaaa aaagacagaa gaataatcca taatcaataa 3186601 atcactaatt aaatataaat ctcgaatatc tttatttaaa gaaacatcgt tcacaaaata 3186661 tttatatttc cctaattaaa ttgttctgaa actggataat accattctta caagaataac 3186721 catagagtct ccaaggttcc ctcttcattt cctctaatca aattaaagtt aaatttatac 3186781 tggccagctt tcttaaaatt cattatcccg caaagttggt gcatataaaa ttatttttct 3186841 ttaattcctt atttgataat gtagaattgg taggggattg tagctaaact gtttccagaa 3186901 tagctttcaa ataaaattaa tttattgttt cttggcagaa ggacaaaaat tttaaacaaa 3186961 actgaataaa ctctaactag taaacttctg caattggtta taataaaaat ttcatcagtg 3187021 aactccttaa agagtgaaga ttaatattta cgcaaacaag aaaaaaagaa gcaactgaat 3187081 ttacttcaag cctcttttag ttagtgcttc tataaactag ccatatcttt tctgatttgg 3187141 gtagttgaaa tgcctgctat tcttgtaagg taaatggcct catagtattc ctttgtagac 3187201 aatcgtacga ttaagtaatc ccaggttctt ttgctctttc cagtagcttc atatgtccat 3187261 agtgaaataa atcaaacatt ccgtacgtat cactttcttc attagataac atcaccttcc 3187321 aaccttttcc aacttagaaa aaacaaaaat ccttaactga ttgtttatca tttcgacata 3187381 ttttttacgt tccattaata ataaacaata atagcatatg ttcctataaa agttaaggct 3187441 ctttaaaaat gtaaatcatc agcacttttt gacaatatcg ttgcattgat gtgtattttt 3187501 tacagatctg atatcttatc tatactcatt acaacaagtt ttctattccg gaagagtcaa 3187561 ttctttttgt cgcgttttca agtgtaatga ttttctttct gctgcgtcat ttattttgta 3187621 cgccctcctc atattacttc atcgtcaaaa cgtgaaggaa ttgtaatacg tagttcctaa 3187681 aaattttcgt ggtaaaattt agtgaagtct ttatcaggct aagggacttt atctaaacta 3187741 cgaattacat atggagatat atagatgaaa aggagggttg atatgatata aacgaaaatc 3187801 aattagataa aggaaaaact gaacacttct gaaaaaagtg ataagtttct ttcactatat 3187861 cctccaaaaa gaacctaaag gtcttggaca tgctgtctgg ttcgcgccta actttatcgg 3187921 cgatgagccg tttgcgtttc tgcttggaga cgatattgtt caggctgaca caccagggtt 3187981 gcgccaatta acggatgaat atgaaagaac actttcttct attatcggtg ttcagcaagt 3188041 gcctgaagat gaaacacact gttatggcat catcgccccg ctgacaagtg aaggccgccg 3188101 ttatcaggtg aaaaacttca ttgaaaaacc gcctaaagac acagcacctt ctaatcttgc 3188161 catcttaggc cgttacgtat tcacgcctga gattttcatg tatttagagg agcagcaggt 3188221 tggcgccggc ggagaaattc agcttacaga cgccattcaa aaactgaatg aaattcaaag 3188281 agtgtttgct tacgattttg aaggcaagcg ttatgatgtt ggtgaaaagc tcggcttcat 3188341 cacaacaact cttgaatttg cgatgcagga taaagagctt cgcgatcagc tcgttccatt 3188401 tatggaaggt ttactaaaca aagaagaaat ctaaacaaaa aggctattgg acattcatcc 3188461 aatagccttt ttttatttca acatcaaagt cagtgtatgc tcttcattat caactgcaaa 3188521 aacctgatca tctgtattca caagaaaacg cttcttgctg ctgtcataca atacatcgct 3188581 atcacttaag gatagtgacg ccgggttgat aggagaaatg ttatgaaaaa taagctctgt 3188641 tgctttatca ttctccagta cataactgat tttttcataa tcaaaattca gcgtttttct 3188701 gccgtcagcc ttatttcctt cagtataacc attcaatttc gattgaatgc tggtgctgct 3188761 gtctcctagg aatttcagaa agtattcata ggaagatgct gcgttttgcg agacataaga 3188821 cgtaaatgca gtggcatgca attcagcgtg tttcatgtta gttgcaacag cgctctgttt 3188881 cacataataa gagtgcccgt caaactttat tttcgctgct tgtttgcctt ttgcagctac 3188941 cgttactttt gtaccgaatg gcagtgtaac gtcagccttc tgtttcaaac cctgatcctt 3189001 ataagcagcc gctttttcat ttgctataaa cccttgctta ttgattgcag ttaagcgttc 3189061 ctctgacttg ccctttgcat cgccatgatg gttcttcact tcattttgcg gaatagcgcc 3189121 aaacgaagca attgtacgaa gcggggcatt aaagaacatc gttcccgcca tgaagacagt 3189181 cagaatagac aaaatagcaa tttgaatggc attggccagt gatttcggct ttttcttctt 3189241 tttgcggaaa cgggcaaacg cttcaggatc ttctttcttc ctctcttctg tctgctcttt 3189301 tttatatgtc tctttttctt ttttcgatag cttattaaac cagtcaataa acgctttgta 3189361 ctctttcaca accgtttttg tttcatcaaa catacgaagc tcgccatagt gcatccaagc 3189421 aacacggtca cacatctttt caatctgacc gattgagtgg ctgacaaaga aaatcgtttt 3189481 tccttgcttt ttaaactcat ttattctgtc tacacacttc tgataaaacg tttggtcccc 3189541 cacagaaaga gcttcgtcaa taattaaaat gtcaggatca atatgcacgg agatcgcgaa 3189601 accgagacgc gacttcatcc cgctggaata gtttttaacc ggctgattaa taaaatcgcc 3189661 aatctcggca aattcaacga tgctgtcata catatcatca atttctttat tggttaaccc 3189721 catcatcaaa cacttgagcc ggacattgtc ccggcccgtt aattggttat tcaaaccggc 3189781 agcaatcgca atcagcgacg gctggccgtt catttcaatt tcaccgctgg tcggcggaat 3189841 aattttagcc agcaggttag acatggtcga ttttcctgac ccgtttattc ctacaaagcc 3189901 gattgtctcc ccttcataca cgtcaaagga gacattccgc acagcaaaaa aaccattatc 3189961 cttagccgga aaaaacaatc ctttaatctt gtccgattgt tttttataca aatgatactg 3190021 ctttgaaaca tttcgaaacg aaacttttag tttcatcgta aaatctcctt acgtattaaa 3190081 gaaagtcaac aaacttgtct ctgaatttca tatgcaggat agaacctact aacaataaaa 3190141 ggaatgtgaa caaccaaaag tacagcgtgt acttcatgtc atggaaaaac catgctccat 3190201 ctaagaagct gttccggaat ccttcaataa tatagaatag tggattcaac ttcagaacag 3190261 gcactaattc ggggtggctt tgaccgagtt tcgcattaac atcccaaaaa attggcaaca 3190321 agaaaaacaa aagtcttgtt acggcctgca gcaaaaattg ataatctcta atcagcacac 3190381 tgatcgttga gttaaacaaa ctaaacgaaa acataaaagc aatcatacag atgaagtaat 3190441 aaatatattg taaccaatgc acactcggga acacaccatt aactaggagt acaatgatat 3190501 aaatcaccat catgatcata taactaaata agttagatgc aattgccacg gacggtagag 3190561 aactaatcgg gaagttcatt ttagccacca tattaatgcg cttaaataca ctatttgatc 3190621 catcaagtat agttggactg atgaaaaacc atgggattaa tcctgccagc atccaaataa 3190681 taaaaggcac ttcgcccgct ccggttgtca caggaccgcc ctttctaatc cccataccaa 3190741 atacgaacca gtaggccagc atttggataa gcggatttaa gaactgccat aagacaccta 3190801 aataattcat ttgatattta gacttggttt cataagccgc caatcttaaa attaaaggaa 3190861 atgacgttat ttgctctctg agtatacgca acaaatcatt cattttttat cttccttaga 3190921 cttaattgtt tttgggaatc tttctgttta aaatttgaaa gcaccgctga ttattgtaac 3190981 agatcctgca ttttttttca cttctcaaca agtatctaaa aagctgccga aaaatcgaca 3191041 gctatacatt ttataaaata acctaaatta ttcagcttta aatacagtat taacaacctt 3191101 ttcagatgaa cgtcctgact ctaaatagca aaacttatca tagaaaggac caaaagaaac 3191161 cggaagctta taatcaggcg atgagatctg cttgatagcc tcaatcgttt cttcagtagt 3191221 ttttaccaaa ggaccaggag cttctttttc aaaatcaaag tagaaaccac gcaacttgtc 3191281 ccggtaggtt tcgatgtcag ggacaaagaa tagcattggc cgttttaaat ttgcaaaatc 3191341 aaagaatact gaagaataat cagtaatcag caaatcagaa accatataca attctcgaat 3191401 atcctcataa gcagaaaaat catatgcaaa tccttcaaaa ggacctaaat caaaattctc 3191461 agctaccaga taatgcattc ttaagattac aatatattca tttccaagtt cttgtctaag 3191521 ttgatgcaaa tctaaatcga gatcgaactt ataacgccct tttgcataga actgatcatc 3191581 tctccatgta ggggcatata aaataacctt tttatcacga ggaatattta acctactctt 3191641 tatcaatgat attgtttcct cattattatc attatgaaga aaatcatttc taggatatcc 3191701 agattcaatc attgtcttgt taaactgaaa cgcccgtgta aagatctcag ttgaataacc 3191761 atttggggaa atcaagtaat cccaattaga agcttccttg ataaaattcc ttttatattt 3191821 tttggtgttt gtaccaggca tatggacttc ttccatatcc attgcaagtc tttttaaagg 3191881 tgtgccatgc catgtttgta aatatgttgt atgactaggt ttcggaatcc ataatggaag 3191941 ccggctgtta acaacccaat actcagctct tgccatagcg aagagccatt ttaatgagag 3192001 gcgattaatg taaggaattc ccttttcatc aaaaggcgct gaatattgtt tatttacact 3192061 ccaatacatt ttatactcag ggtggttttc ccgcatatat tcgtaaatcg ctctcggatt 3192121 acaactgtat tgtttcccat taaaactttc aaaaatgact gttttccttt taactggcat 3192181 tctgctagcc atcatgaata gagatttgta tgttttagtg attaacttgt ttctcatttt 3192241 tgtgatcttt tttatttttg atactaatct cttcttcttt cctttaataa agtatttcat 3192301 ccttgttttc aggctatagt cgtttactct gatacctaga gtctgctttt tctttttctt 3192361 aaagacttca taacgaactg gtgcgttgtt tgttttaata atacttacta atccttttaa 3192421 tttgtttttt cgatctccta aaacaagagc agtgctgttg aactgaatat ccgttccttc 3192481 atcgtcattg catatatact ccataaaaag acgataaaca taacgttttt catttgagaa 3192541 aggaatttct ttcaaaggca ctttcacttc aaaatcatac agttccggaa caaaaccatc 3192601 tgctctcatg ttttccaggc catgtgtttt tctttctagc ttgattggaa atttttcctc 3192661 aataggtgtt tctccaccct tttttaaaat aaggttcaag ttttttatcc gatattgatt 3192721 ttcggaactc aggtaccccg cataacctgt tatgcttatt tcttcagagc taatctcgat 3192781 ttgatcaaat ctgatgattt tggcctctct tttcacctta atagaaaagt tgcctttatc 3192841 agttgtataa ggtaaaatca aaagttctgt ggtttgatcg acatgaaagg cgcgctcaat 3192901 tgaatttact tcagcagaaa gacgcttcaa gagtggttcc tgctccgcat cttcatattt 3192961 ttttcgaaat tcgacataaa aatcatatgt ttgtcccatt tcaacaggca taggcaaaac 3193021 atgagcattt atctcagttt tatactctaa tgagccagtg ttttgaagcg gaaattcaga 3193081 ttccgttcct gaacgtctct ctttcagctt taaaaataac tggtaatcct ctaaaaattg 3193141 gtgttctgaa tcaattgaga ttaacaattc aagacttcct aaattgtttt tcaagctttt 3193201 caaaatacat ttaatcacag tgttttcaat cattactttt ttctgctcct ctgtataaaa 3193261 gctctttcct ttttgcttcc ttttattagt gtcaactact aaggacatta actctctttt 3193321 atttccgtga ccctccaaga gaaattgcct ttaactgttg tatagggctc tactctatag 3193381 ccattattag tatctatact gtttcctgac aattttgttt cttcactcga aagtcttcgc 3193441 attgttttaa tatggccatt tgcattgaaa acaatataaa aatcaataac ttgggtttta 3193501 ttagcagcta tcttttcaat atttacatct ttttcgagat caattacaaa cagttgatca 3193561 ttttgtaagt ttgttgaaat aatttcagcc ttattctttc tgtccaagcc cactaaacgt 3193621 atttttttaa tatcattatg atcaaaattc tcaatgtcaa tttctatttt agttttatca 3193681 aaatcctcag tataggaact aatagaagga tctttttttc caaccttttt agagaacttc 3193741 tctctttcta ttcgcacctc aatcatctga ttaagagcaa aagcccaatt ttcaatatag 3193801 ttgggtcttg aatatttttc agccatttta aaagcttgtt ctgaaaattt ttgatgagta 3193861 ctttcatctt tcatcaaaga gataatagct tgacccaatt tctctatatt atactgttca 3193921 atgacatatc catttgctcc gtcagtaact aagctccttg ctccgtaatc ataatcgtat 3193981 gttacaactg gacatccatt gctcagtgcc tccatatttg atagaccgaa cccttcaaaa 3194041 tgagaggttg aaatggttag ccaagctttt tgaaactctg agtcagggtt atccgtatag 3194101 cctttcaaaa agacattgtt ctgcagtttg gtatcttcaa tttctttttt tattttttcg 3194161 aaatcttcac ccgatccgaa tatatcaagt tttgcttcag gaatttcttt cacgactaaa 3194221 ctaaatgctt ttactgcatg tatcagattt ttcatagatg caagtcttga aataatgaca 3194281 gctttgtatt tttcactcgg cacattcaat acagcgggat caagaggctt atcaattgta 3194341 tgcggagtaa agaaaaacgt ctcttgttcc cctgaaatca atttaaaatc ttctagctgc 3194401 tcctcagtta taaaaaagac agcatccaaa ttatacatct gactaaatac ttctttatag 3194461 cgacccttaa tttgatattt attgctgccg taatgcttgt tatgaataat tgctccataa 3194521 taggaagaag gtgatttttt cactttaaag acatgtttgt cttgcggtct gctgtccact 3194581 aaaaacaact taggtttatc attttgtttt tgcagatatt ctatccaata ttgacgcagt 3194641 tccgattcat cttttacttt tatctcaccc tcaagggagt accaaataat atgagataat 3194701 tgaacatctt tttcttcatt gttccataca tagagtttgt ctaaatatac ttgattttgg 3194761 tcattaatat attcctgcag atacatcttg tttagctgca catcataatg agtaacgaga 3194821 actaagtttc cgttcttcgt atattcctct ctctttatga gctggttttt atcattccaa 3194881 tagtcgacgt accggatagt ttctccatct ccgtagtaaa ctacagacat ttcattgttc 3194941 ttcttaccaa acaatctcaa cagagttttt gcaaatttcc ccattccaac ttgctttttt 3195001 atctggtcaa ggcctatcct ttcttcgtat gatcttttcc catttgttct aacacttaaa 3195061 aaatcatcga atagattaat aacacttgtg aattttttat caatcttacc gttgctgtac 3195121 aattcatcaa tttttgaaga caactctaaa tcaaaacgaa acgttaagaa aaaggtgttt 3195181 tggttacact cttctccaaa taattttgaa cgcaataata atgatttcgt cagaccgcca 3195241 taattacttg gcagtccacc agagataaaa taataatcca tgtcaggaat ttgttttata 3195301 ttagattcac tcaccgcatg taaagacaat tttttactcc ctttcggcat ctagaatata 3195361 tgatcattga aatttatatc tacccggata ctttagtcac aaaaatcaat gtaagcatca 3195421 aaaagtactt cttatttcaa taagaagtac tttaattaga tattgaacca atgatatcag 3195481 gatcctaaat tataaaccag caatttcctc tttgatcttt gttgtagaga tgccttctgt 3195541 tcttgggagg taaacaacct cacactgatc tttgagaaag tcaaatttac cttcccagtc 3195601 atcccccata acaaaaacat caatattatg atcaataata tcttgctttt tttgctccca 3195661 attcttttca ggaattactt cgtccacata tcgaatggtt tctaaaatta atttacggtg 3195721 ctcatagctg tgataagctt ttttttgctt ttgtaaattg aattcatccg ttgaaatagc 3195781 aacaactaaa taatcaccaa gctgctttgc acgctcaagc aatttaatgt gaccccaatg 3195841 cagtaaatca aaagttccat atgtgataac ttttttcatt taaagaaacg ctccttccta 3195901 atgttaaaca ctattaaaaa cactactgac gttagcgatt aaattctaaa aacctgtttg 3195961 tattccttat atcgacatat ttctcgtatg tcttcactga tcattaatta tagcataccg 3196021 cctaaaaaag gttaagtact catgaggaga aaaacattcc aaaatatgta attacactca 3196081 gactccattg gcaccaaggt ctgttgttca ttcgttcatt caattgtaaa attggaaaca 3196141 tatttaaatt taatgtaaag ataatgttaa tcctttgttg aagatttatg ttaaaatata 3196201 aggtagcttg attttgcttt tagaaactct cggtttttaa ctatataaat agaatcttaa 3196261 aggaaggagg agccagacat gcaaacagag actattcaca atattcctta tgttaacagt 3196321 aacttaacat catttatcga ttacctagag aaacattata ttgatcaaaa gattggtgct 3196381 gtcatttcca cagtcaaccc tgaaattgca tttgcagcta ttaaagatcg ggactacttt 3196441 gatgtactat cttcttcaaa cttcattttg cctgatggga tcggtgtagt catgatgtca 3196501 cgtttgacta acaacaggct tcagtcccga atcgcaggtt acgatgtttt taaagaactt 3196561 ctgggcgttg ctaacaaaaa gaaaaaacgc atatttctgt acggtgcgaa gaaagatgtt 3196621 ataaaaggtg ttgtatccaa aatttcttct gaatacccaa acattaaaat cgcaggttat 3196681 tcagacggtt atgttcaaga tcgcacccta gtggcaaaac aaattgcaag agcaaatcct 3196741 gacatggtat tcgtagcttt agggtatcct catcaagaga aattcattca taactacaga 3196801 cacttgttcc ctaaagccgt atctataggt ctaggaggaa gctttgatgt atttagcggt 3196861 aatgtcaaac gggccccttc ctggatgata cgtttaaatt tagaatggtt ctaccggtta 3196921 atcttgaatc catggcgatg gaaaagaatg cttagcatcc caaaatatgc tttaacggtt 3196981 ttaaaagaag aaaaaaacaa aaaaactttc tatccaaagc ctgaaaaaga tcatacaaaa 3197041 cagatttaaa aacaaaactt tcaaataaat ggatgataaa aatgaaaata agatcactac 3197101 tggcgaattg ctatttgtat tttttatcag caatcgcctt ttttctgcaa tgggtgaaac 3197161 ctgaaagcaa agtgaccctc ctgatctcat tcgaagcaaa cgcaaaagcg attcttgagg 3197221 aatatgaaca aggacaatac tcttataaac ttaacatcct gtatacccag caggcctctg 3197281 ctattgccga gagcttcccg aatgtagatg catatttatt acaagaaaaa aaccctatcc 3197341 atctcattaa agctgtatac ctaatgttta acagtaaagt gatcataaca gataattact 3197401 ttctattaac aagtgtgtta aataagcgga agcaaacgaa atgtatccaa gtatggcacg 3197461 caaatggctc actcaaaaaa tttggtttgg aagacattac aaacatgcaa cggacgaaaa 3197521 ctgatattaa aaggttccaa aaagtataca gttcgtatga ttatttaact gttggctcag 3197581 aagagatggc aaatatcttc aagaaatcat ttggaataaa ggataaccaa ttattaaaaa 3197641 taggtgtacc tttaacagac ccttattacc gagaaaacaa gaaaaaaatt tcagatactc 3197701 taaacataca aagaaaaaaa ataatcctct atgcaccgac gtttagagat tataatatgc 3197761 aatcaattca attgcctttt acagaagaac aattaattca tcagttaaaa gaagaatatg 3197821 ttttatttgt taagctgcat cccgccattc agaacaatat tgatattaaa tattccagtg 3197881 attatattaa agatgtttct aactatgcct tgtttgatct actcatggct gcagacatat 3197941 taatcactga ctattcttct gttccctttg aattttcgat tttaaataaa cccattcttt 3198001 tttatactta cgatttaaaa ctttatcaac agaagcgggg attggttgat aattatcttt 3198061 ccataatacc tggaagagcc tgctatgaca gtgaatcatt aataaatgaa attcaaaccc 3198121 catttaatta ttccaaaata aaagtttttt ccgatagatg gaataagtat tctgatggga 3198181 attcaagcca aaatttattg aatttcatcg aaaatttaat aagctaaatg atgacacttg 3198241 ttcaaaacag aacaagtgtt cttttttcta ttgaataccg aacgtatgtt tgctttaatg 3198301 taattagttg cttatggcag caaataataa tagaggtggt aaatttatga gaaaaaaaga 3198361 actgtttgat ttcaccaaca tcacgccaaa attatttact gaactacgtg tagcagacaa 3198421 aaccgtactt caatcattca atttcgatga gaaaaaccac caaatttata caacccaagt 3198481 cgcaagtgga ttaggaaaag acaacaccca aagctatcgc ataactcgtc tatctcttga 3198541 aggtttacaa ttagacagca tgctgttgaa acatggaggt catggtacaa atattggaat 3198601 tgaaaaccgt aatggcacca tttatatttg gtctctatac gataaaccaa acgaaacaga 3198661 taaaagtgaa ttagtttgtt tcccatataa agcaggcgcg actttagatg aaaattctaa 3198721 agaacttcag cgattctcga atatgccttt cgatcatagg gttacacctg ctcttgatat 3198781 gaagaataga cagttggcaa ttagacaata cgatacaaaa aataataata ataaacagtg 3198841 ggtgacaatc tttaacctgg acgatgcaat agcaaataaa aacaatcctc tttatactat 3198901 taacattcct gacgaacttc attatttaca aggtttcttt ttagatgacg gttatttata 3198961 ttggtataca ggagatacaa acagcaaaag ctatccgaat ctcataactg tatttgattc 3199021 cgataataaa atagtgctgc aaaaagaaat tactgttggc aaagacttgt ccaccagata 3199081 tgagaataac ttccgtgaac cggaagggat ctgtatgtac accaatcctg aaactggggc 3199141 aaaatcatta atggtgggaa ttacaagtgg aaaagaagga aatcgtataa gcagaattta 3199201 tgcataccat tcttatgaaa acttcatgaa tcatgtacct atgcttcgat cccctttatt 3199261 aaaaaccgtg gggcaccaag atacacctcc agaaagattt caaccattta ttcaaacctt 3199321 cattttagag tataatgctc aaaacaaaaa atggatggtt ccgacttcag gttatttacc 3199381 atcttacaca tcaaatttag tccgaaatat tactatcaat gcagatggaa acttgcaagt 3199441 cacattaaat gaacgctata ttagtttact gcatcaatcg atagaaggag atttccgctt 3199501 aaaacaaaag gatatccgaa tgggatcctg gtattttgcc ggcggagaaa aatcaaatgt 3199561 gcttgaaata ggttttatga aagggagtac aaaaatcaga cccgatgatg cagccatctc 3199621 aaatgcttca agaatgagta tttttatgat tgttgcggac aagattgagg tgtgataatc 3199681 aaataggctg tagctattta atagctacag cctatttgca actttctaag ttttttatcg 3199741 atattccgga acatcaaaat aaagtgtata accgtccagc aatgaataca ggctgtacat 3199801 gcggtttact tgtttgtacg cccagccgat gtctgttgcg tattgatgtg tcgctgtagc 3199861 tgaccatctc attttgtaca gtgtgtcttg attgtaagct gtgttgtgga tatacgatga 3199921 gcctatgaat ttagctccgc cgataatggc cgcttctggt gtgaaccagc cctgctcgta 3199981 cgcatatttg gctccgtagt aattcggatt gctgtcgtat gctccaattc catacatgtt 3200041 gtatacggtt tttccgttat aggttaatcc attggctaaa gcggatgtcc cgtttcctgt 3200101 ttccagaaga gcgtgtgaga ttaaatacag ttcgttgatg ctatattgat tggcggcatc 3200161 gataaatgcc tttgctctcc ctgtcaggat gcctttaccc gcaagcactt tctgatttac 3200221 ctcagtaacg ctgagacccg ctgtctgtga cagcttgaga aattggaagt agtatttgct 3200281 gtctctggaa aagttattcg gatccacgta ttgaactact tcatcactgc ttgcgtttcg 3200341 ccagcccaaa ttgatcttag cccagccgtt tatctgtccg atgactttca ctttatcgcc 3200401 ttttttaaac tggccgatca cgtttgtcgg gctgacttcc ggcgttgacc ggatatttag 3200461 tacatcagcc gtaacagttg atgttgctgt attaatgtac gtgagcgata cgtaagccgc 3200521 tccgtctgtt tgcggactta ctgtcatttg tttttggacc atatcacgaa gcgagagatt 3200581 gtagtttgtt ttcatgattt gcgggccgtt tttgatcttc acgatagatg atgtccatcc 3200641 gtataattgt tttagcttcg ttgatgccgc agcagctgta tcattgcctg tgaactgctc 3200701 atttacgctg attttataaa gcgtattgct tttcgttgta tagctcgggg ttacactttt 3200761 cgatttaaga taggttaacc cattgttcaa tgcggttttg ctgctaagct gtgttgtcac 3200821 gattttgtat tgtgtatatg cagtctggcc tgtttttgat gttgtgactg cgatatgatt 3200881 ttgtttgaaa aatgttaaaa cgcggtcaat ctcttcttgg ctgatgatag cttcagttgt 3200941 gatttgatag ctgctcgcag ctgtctgacc ggttttctgg cttgctactg atatatgatt 3201001 cgatttgaaa aacgtgagtg cctgattgac tttcgtttga tcaagcagag attcggttgt 3201061 gattttaaac gtgtcagcta tttgtttttt gacggatttc gcagaagcac ttagctgatt 3201121 tttctttaat atgttcaaac cctttgtgac ttttgcttga tctgatgttt cttctgagat 3201181 gagctgatat tgattttctg ctgttgatcc agctgctgtt tttgcagctt ttactttttt 3201241 ctgagcaaag aaggctgctg ctttgtttgc ttgctgctcg cctaaaatct ttgccgtcgt 3201301 gatttgataa gctgcagacg ttgtcgtttt tttgacgctg gatgacgtgt aatgccattt 3201361 tttcttttta aagaaagtgt ctattttttg gagctgctgt tttgttatac ccttcatatt 3201421 cacggtatat gatgtgcttt ttccaacctg ttgataactg ccggatacgc cagtgttttt 3201481 cttgatttgg ctgatggcgt cctttactgt actcagccct ttgaaataag ctgattggac 3201541 attgtatgac tcaacggttg ttttttgatt gatggacttg tagctgcctg tgatgccagt 3201601 gctctgtttc agctgctgca atagagtttt ggcattggct tcacctgaaa tggcggcagt 3201661 tgtgaacgta taataggctt gccctttcac tgtttccttt aatgatgcct gcagcccaga 3201721 ttccttttgg aaggcgtttt tgatctgcgc tgctctgctg tctcccacga ttgtgccaga 3201781 ctgaatggtt gtgacagaca ccgtgtgtgt gatgggctga tacgagcttt taatccccgt 3201841 ttgcttggcc aggctctgga taagcgcctt gacttttgtc tcatcagcaa tgtctgatgt 3201901 catgacgttc atatagggct gagctgctcc gtaagctttt acagcgccag ccactcccgt 3201961 ctcctgtttc agctttgcta ggatagtgtt ggcctgtttt tctccggaga tggcacctga 3202021 cgagatggtg acatatggct gtttgcttcc aacaggactt gacgttcctg taattgatgt 3202081 ctgtttggcg agtccgctca gtattgcttt cgcttctgat tcgctatgaa tgcctgaggc 3202141 ggaaatttgg taggtcgttg ttgtgcctga agcctgatag gatgcatccc agccagtatc 3202201 tttttccagt ttggcgacag cttgtgaggc ttggctttct gtactgaacg tattcgacgg 3202261 ctctacttta tatagtgagt agtcggtata cgcggctgcc tgggcagaac cagacatggc 3202321 aaaaaaggca agggacgcgg cggatagaag cataggtgcg attagtctct ttttcattcc 3202381 ttctcctctt tcttattcta tgagtatata aaactagttt atttatcggc acgcgcatgc 3202441 ttcatttata ggtgaatcac ttccattttc taataaaaaa acttaacctc gaagtgagat 3202501 taagtttaaa tatgagacac gataagggta caagttcctt ttatcgtaaa atcgggcatt 3202561 tgagccggca aaataaagtg atcacctttt ttgagcggac atgttttgtc ctcatacttg 3202621 agcaaaccgc ttccttctat cacgctgcaa atcagaaagg attcatcctg agccatttca 3202681 gcttcgccat tgatgtccca tttataaacc gaaaaatatt ccccttggac aaatgtttta 3202741 atggttattc cttttcttga ttctgtcgat tcatctatat acccgtccac atggggaacc 3202801 gtggcggcat tgaccgcttt ggcaaaatga agctctctcg gacttccgtt gctatcaaga 3202861 cggtcataat cgtacacccg gtatgtggca tctgaatttt gctgagtctc taaaacaagg 3202921 gcccccttgc acaatgcgtg cagcgttccg ctcggcacat aatagaaatc acccggttta 3202981 attttgattc ttcgcagcag gccctcccag tcaccgctgt tgatcattgt gacaagttcg 3203041 gtttttgagc gggccgtatg cccgtaaatg atttctgcgt tttccttaca gtcgataatg 3203101 taccagcatt ccgtcttgcc gagttctccc tcttcgtttt ctccggcata gtaatcatca 3203161 gggtgaactt taattgacgt atcttccttc acatccagca gctttgtcag aagcggaaac 3203221 cgatccccct ctacgccgcc gaatacttca cggtgctctt cccaaagctc gatcaatgtc 3203281 tttcctttat acgggccatt tgcaacagtg ctcggtcctt ttggatgagc ggaaatggcc 3203341 cagcattccc ccgttgattc tgaaggaata ctgtatccaa atctatctcg taaagcggtt 3203401 ccgccccaga ttttttcttt aaacacaggc gttagaaaaa tcggtgattg cgtcatgatc 3203461 cgtacccctc ccctgtaaat aactgatcat cattttcccg gtgcgcccct cttacaaacg 3203521 cccgtataag ctgccttttt cctatgacaa catatgtaca aagcatcatc ttttcattac 3203581 cccttcaaag aaaacgcttc ctatctatta tatcacgtcg aaaagaagct ttgtttcagc 3203641 cttttcctcg ataagaataa ttctcctttt ttgatacaaa ttaataaaaa ccgtcaatat 3203701 gtttaagaag gagagaaact atgcaaatcg actctgatct ccagaacaat ttagacacac 3203761 tgaaaaaaac attgggacaa aacgacgata tgatgtttta tacatttgct ttcggagata 3203821 gcagacaaaa ggcgtgttta ctgtatattg acggtctgac agagaataaa atgctggcgc 3203881 aatacgtcat ttctccttta caaaaagagg cgttggccca taaggaatgc tcgattgaag 3203941 acttatccgc cttttttttc ggctttcacc acagcgttgt ttctacaatg aaagaaatag 3204001 agcagctcgt tttttcaggg caagccattt tgctcgctga tggctatcgc ggaggattag 3204061 ctttcgacac aaagtcagtc gcaacacgca gtcttgatga accctcctcc gaagtcgtgg 3204121 aacgcggccc taaaatagga tttattgaaa agctgcggac aaacacggcg cttttgcgtg 3204181 aacggacgag tgatcctaat ctcgtcatca aagaaatgac actcggaaaa aggaccaaaa 3204241 agaaaatcgc tgtcgcttat attcaggata tcgccccaga ttatgtcgtc aaagaagtgt 3204301 ttaaaaggct gaaatcagtc aatatagata atttgccgga atcggggacg cttgaacagc 3204361 tgattgaaga cgaaccattt tcaattttcc ccacaatatt aagcacagaa cgaccggacc 3204421 gggtcgaaag ttctctatta gaagggcgag tgtccatatt agtggatggt acgccgtttg 3204481 ctttgattgt accggctacg gttgacgaat ttattcattc gcccgatgat tacagccagc 3204541 gctggatccc aatgtcactt gtacgccttc ttcgttattc cagcatcctg atcaccattt 3204601 atttgcccgg tctgtatatt tctctcgttt cttttcacac cgggctattg ccgactagaa 3204661 tggccatttc cattgcaggc agcaggctta acgtaccatt cccgcctttt gtagaggcct 3204721 ttatcatgat ctttacgatc gaattgattc gagaagccgg attaaggctg cctaagccga 3204781 ttggacagac aattggcctt atcggcggcg ttgtcatcgg acaggcagct gttcaggcgc 3204841 aaattgtcag tgcgcttatg gtcattgtcg tttctgtcac agcactggca tcctttaccg 3204901 ttccttcata cgcctataac tttccgctgc ggatcattcg gatcggggtt atgataagtg 3204961 caacagcgct tggcatgtac ggcgttataa tggtttatct gtttgtgatc ggccatctca 3205021 tgcgcctgaa aagctttggc caggattaca ttatcccgat catggcgcag cctggacagg 3205081 atttgaaaga cacagtcatc cgtattccca cgatgttttt aaaaagaaga ccgacacgaa 3205141 acgatcccga agataacatc agacaaaggt gatggctatg aggaaatcag agcataaact 3205201 gacatttatg cagacgctca ttatgatcag cagcacattg attggtgccg gggtgctgac 3205261 ccttccccgc tcagccgccg aaaccggcag tccgagcgga tggctaatga tactgctcca 3205321 gggcgttatt tttattatca tcgttctgct ttttttgcct tttcttcaaa aaaacagcgg 3205381 aaaaactctt tttaagctca acagcattgt agctggaaaa ttcatcggct ttctattgaa 3205441 tttatatatc tgtctatatt tcattgggat tgtttgcttt caagctcgga ttttgggaga 3205501 ggttgtcgga ttctttttgt tgaaaaatac gccaatggca gttgtggtgt ttatatttct 3205561 tgcagttgcc atctatcatg taggcggagg cgtttattca attgcaaaag tatacgctta 3205621 tatttttcct ataaccctta ttatttttat gatgcttctg atgttcagct ttcgcttgtt 3205681 ccagcttgat tttatccggc cggtatttga aggaggctat caaagctttt tctctttatt 3205741 cccaaaaaca ttattatatt tctccggatt tgaaatcatt ttttacctgg tcccctttat 3205801 gagagatcca aagcaagtga aaaaggctgt tgctctgggc atcgcgactt ccacattgtt 3205861 ctacagcatt actttgctca ttgtgattgg ctgtatgact gtggctgagg caaaaacggt 3205921 gacatggccg accatttccc ttattcacgc attagaggtt ccgggtattt ttattgaacg 3205981 atttgatttg ttcttacagc tgacctggac agcccagcaa tttgcctgta tgctcggatc 3206041 ctttaaaggc gcccatatcg ggttaacgga aatctttcat ctaaaaaata aaaacaatgc 3206101 atggctgctg actgcaatgc tggctgcgac gtttttcata acgatgtatc ccaaggactt 3206161 gaatgacgtg ttttattacg ggacgcttct tggatatgct ttcttaattg tgattacaat 3206221 tccattcttc gtctggtttt taagctggat acagaaaaaa atagggaggg ggcagctgca 3206281 atgaaaacag catcaaaatt ctccgtcatg ttttttatgc tgctggccct ctgcggctgc 3206341 tgggatgtca aagatatcga gcaactatcc ttcgccagag ggctggcgat cgatgagaca 3206401 aatgatcacc agtacaaact gacgtatcaa aatcttcttc cccaaagcga agacagccaa 3206461 gcatccggaa aacccgaatt tgttaatgta acgtcccacg ggaaaacgat tctggaagca 3206521 gtcagtgatg tatccatcaa ggaccctcct gtttatagcg atcatttaaa agtgatcctt 3206581 ctgggagaaa aactgatgag gaatcaaaat gtagaccaag tcctcaacca ctttatccgg 3206641 gatgatgagc tgcggcgaag cagctatttg atggcagcca gagggaatgc agctgatgtt 3206701 ttcacaaaag gaaaccccaa tcagcagcag ccgatgccct ccgaaaaact gattgatttg 3206761 acaactcaca gcggatataa cggtaagatt atgataccgc tgcgcatcgg aagagcttct 3206821 gtctactctc agaacgggta cagttatctt attcaagccg tgaaaaacga aaagggaaaa 3206881 gccaagtatg acggagcagg cattatcaaa aggggcagca ataaactcgt tgggtttctt 3206941 tcagctgatg aaacccaaac actgtcatgg gtcatgggga cgatccaagg cggtgtcatg 3207001 ccgacgacag ataaaggaca tccgattacg tttgaaatta aaaagtcgaa aacgaaaatt 3207061 aagcccgtca ttgaaaacgg aaagcctgtc tttcatattt ctgttaaaac gaagggcatc 3207121 ctgacagaag accaaaaccc gaatgaaaac tcctttagca aaagttattt gcacaggctg 3207181 gaaaacattt ttgaaaaaaa gcttgaacga gatgtaaagc aggtgatgga taaactgcag 3207241 cacgagtata aaaccgatcc ggtcttttta tcagaccaca taaggattca acaccctgac 3207301 tactggaata aagtaaaagg gcattgggat gaaatatttt ctgagactga ttttaagtac 3207361 gatatttctt ttaaaatcat taactttggc acggtgggaa agtaagcaat caaaagggtg 3207421 cgcatgatcg cgcacccttt tttatgttcc gacagtctgc tgttttccgg ccgctcctcc 3207481 ctgtccgttt ttgtcccgta aatcctgctc aatttcttca aggcttcttc cctttgtctc 3207541 tgtcacttta aatcggacaa ataagaacgc catgataccg atcgcggcat aaatcaggaa 3207601 taaataactg attccgatcg cttccattaa tattggatag gttaatgaaa caatcagtgt 3207661 cccaacgtgc aacattaagg tcgaaacacc ggtcccgatt cctctgacgt gaagcgggaa 3207721 caattcagga agcatcaccc acacaaccgg tccccagctg accgcaaaga caacgataaa 3207781 cacgcctaaa caaatgacgg tcgtccatga ggcagccgga gtgttatcga aaaagagatt 3207841 tactaaagcg agaacgatca agctgatcac catgcccgca ttcccgaata gcagtaacgg 3207901 ctttcttcca atcttgtcga tgattttaat cgctactaat gtcatgagaa cattgactgt 3207961 gccgattccg accgtgccta aaatcgaagc ggagtttccg aatccgacgt ttgtaaaggt 3208021 ctttggcgca tagtagatga tcgtattcgt tccgataaat tgctgcaaaa aagcgagtcc 3208081 caaacctgca ataagcgctg ggcgcaccca tggatcgaac agctccttca gaccgccttc 3208141 atcctgcttt tccgcttctt ttatatcatg tatttcctga tcaatatctt ttgtgccacg 3208201 caatttttca agaattttct tcgctttgct ttcttcgcca ttcgtgaaca gccagcgcgg 3208261 gctctccggc ataaacaaaa tgccaataag caagagcaat gacggcacag cagccaatcc 3208321 aagcatccag cgccacgctt cggcatcggc aaatatgtaa ttgacaatgt aagaaagaag 3208381 gatgccgacc gtgatcatca gctgattcag tgatgacagc gccccgcgtt tatgttttgg 3208441 cgccagttca gataaataaa ggggtacgat tgtcgtcgat gttccgactg caagtcccaa 3208501 aatgatgcga aacagcacca tgactcctgt atttggggcc agtgccacac caagaccgcc 3208561 tatacaaaac agcagcgcgg ctgccataat tgcttttttt cttccgaaac ggtcagtcag 3208621 cttgccggcc gctcctgagc ccaatatcgc cccaaccagc aaggagctga caacaagacc 3208681 ttctgtaaac gcgtttaagc ctaactcctt tttcataaat aaaatagctc cggaaatcac 3208741 tccggtatca tagccatata acgcgcctcc aagagctccg aaaaaataaa gccatatatt 3208801 tgactgcttt ttcataaaga tgactccctt tctccatcag ctgcaatgac attgtctgtg 3208861 ggattttttt agaaatcttt tagcctcttt ttccggccat taaacctttt tatttttctg 3208921 atcataagtt ttccaatcat ttacttgtat ttttttcaat gtcgccgaaa cattttacct 3208981 gctgcggcgt ccaatataag gtgattcagt acattatcgt tatcaatttt caaaaacaag 3209041 aacttataaa tataggaata tttatcgaaa aatgtctttc gagtagttgc cccatggcaa 3209101 atagaatggt acgcttcaaa tattaaagaa acgtgaggta ttgatatatg gaagaacgat 3209161 cacagcgcag aaagaaaaaa agaaaactaa aaaaatgggt gaaagttgtt gccggattaa 3209221 tggctttttt agtcattgcg gcaggctctg tcggcgccta tgcttttgta aagctgaaca 3209281 atgcttctaa ggaagctcat gtcagccttg cacgcggaga acaatctgta aaacggatca 3209341 aagaatttga tcctggaaaa gattcttttt ctgtattgct cttaggaatt gatgccaggg 3209401 agaaaaacgg cgagaccgtc gatcaggcaa gaagtgacgc gaatgtgctg gttacattta 3209461 atcggaaaga aaaaacagct aaaatgctga gcattccgcg tgacgcctat gtaaacatcc 3209521 caggccacgg gtatgataaa ttcacacatg ctcacgctta cggcggcgtt gacttaactg 3209581 tgaaaacagt tgaagaaatg ctggatattc cagtcgatta tgtcgtagaa agcaatttca 3209641 cggcttttga agacgtcgta aacgagttaa atggcgtcaa agtaactgta aaaagcgata 3209701 aagtcattca gcaaatcaaa aaagatacaa aaggtaaagt cgttcttcaa aaaggaacac 3209761 atacgcttga tggggaagaa gcgctcgctt acgtaagaac acgtaaagcg gacagtgacc 3209821 ttttacgcgg gcaaagacaa atggaagtgc tgagcgccat tatagataaa tcaaaatcat 3209881 tgagctcaat tccggcttat gatgatattg tggatacgat ggggcaaaat ttaaaaatga 3209941 acttatctct taaagatgcc atcggcctgt tcccgttcat cacttcattg aaatcagttg 3210001 agtctattca gctgacgggt tatgattatg aacctgccgg agtctattat ttcaaattga 3210061 atcagcaaaa gctgcaggaa gttaaaaaag agctgcaaaa cgatttaggt gtataatgaa 3210121 cgggatggcg attacgccat cccgttttac atatttcctt gttgaaaatt atcaaagtaa 3210181 cgtttagcct taatttatat ggattatgtt tcacaggcaa gctgaacata ctacacgaag 3210241 cagcttcatt tttaaggagg ttcccctaca tatgaaatgt attgcgattg atctagacgg 3210301 aacattactg aataaagaaa gcgtcatttc tgcggaaaac agagaggcga tcaagcgggc 3210361 cgttgatgcc ggcatcctcg tcaccatttg cacgggaaga gcgacatttg atgtaaaagc 3210421 gctgctggat gacttggaca tccctatcat tgcagctaat ggcggtacga tccacgacac 3210481 gggttaccgt ttgatcagcc ggacattaat ggatcaggaa gccggtaaag cgattgctga 3210541 ttacttactt tcaaaaaaca tttactttga ggtatataca gatgaccatc tgctttctcc 3210601 ttttgacggc gaagctaagc tgcacgcgga gcttgacatt ctaaagagcg caaacccaaa 3210661 cgagcagacg gatgacttgt ggcaaggagc catgactcaa ttcaaacagt ttggcattaa 3210721 accaatccct catatcgaat cggtttttga cggcggtgaa aacatttata agcttctttg 3210781 cttctccttt gatatggaca agctgaaaca agcgaaggaa gaactgaagc atcataaaaa 3210841 actggcgcaa acctcttcag gaaaacatat tatcgaaatc ctgccggcct cgtcaggaaa 3210901 aggacgcgcg ttaacaaagc tggctgacat atacggaatt gaaacacagg atatctatgc 3210961 gatcggcgat agtccaaacg atttgtccat gtttgaagtc gccggacacc gtatcgccat 3211021 ggaaaatgcg attgatgaat taaaagaaaa aagcaccttt gtcacaaaaa gcaatgacga 3211081 aaatggtgtg gcctacttta tagaccagct tctttcgggg caatatgcat aaagaaaaga 3211141 ctccagagat tggagtcttt ttcttttatt gcacccgtat acttcctgcg tatttatcct 3211201 tccaatatgt gctcgtgttc atattggtaa tggtcacgcc gtttgataat gtgacatgaa 3211261 caacttgtcc gtttccgata tagatggagg gatttaagct tgttgattga aagaacacaa 3211321 tgtctcccgg cttcaggtcc gccttctcaa tcttagttcc ggcattgtac tggcttgttg 3211381 cgtatcgagg cagggaaata ccggctgctt tctggtatac atattggaca aatccagctg 3211441 tatcaaatcc cgtctcaggt gttactccgc cctgtttgta aggcacttct ccgacataaa 3211501 gcgtcgcttc ggaaacaatc ggattttctt tcgggattgt caggttgtca aatcggcgaa 3211561 tacccgtcat cttcgatttc cagtaatcct ctgacaaata ggaaatggtt actttttctg 3211621 accggcttgc ctgaatgaac ctgcctgcgc ccgcataaat gcctgcatgt gaaattcccg 3211681 ttttatacgt attgctgaaa tagacgacat caccaggctt tatgttctga ggggctacct 3211741 tctcgcccac tgcccactgc tgttcggctg atcgcggtag ataaatgccg agtgcctgtt 3211801 gaaacacata ttgcacaagc cccgagcaat caaagccctc tgacggcgtg cttccgccaa 3211861 acacatatgg gacaccgata tatttttcgg cctcctgaac gacaggaaca tcagccgttg 3211921 ccggatcggc agcgattcgt ctcgccccga tataagttcc gctccaatag ctgctttttt 3211981 tgtaattggt gatgataacc ccttttgact gtgtactgtg aaccatttgg ccgtctccga 3212041 tataaagggc gtcatgtgtc ggaacagtgc cggtgcttcc ctctttcttg aaaaacaaaa 3212101 tatcacccgg cttcaggttt tccggtttta cagctgttcc gattttatac tggtcgttta 3212161 cagatctcgg cagatgaata tcagccttac tgaacacata ttgtatcaat cctgatggat 3212221 cgaaaccctc tttcggcgtt tccccgccat atttatactg atatccaagc aggttttttg 3212281 cttcgctgac aatcaattct gatgatgtat cagcttccgc aatctccgct tttgtcataa 3212341 ttggaaccaa aaaacaaatg ataaccgcca caagcaaaaa cttcttccag tttgccagtg 3212401 tgttcacttt tattatctcc tcctcttttt gcagttttaa catcggtatt tttttgaata 3212461 tgttaagaga ctttttaata tttttacaga atgaatatgc tgggcaaata aaaagagagt 3212521 gtctcatcag acactctctt ttttgaatta tttattggcg tttaccggtt cttcctgctg 3212581 ctggatttta ttcatttcca tatcaatctt ctgtttttcc tgatctgtca gctgatcatt 3212641 gaatttaaaa gctgacataa acatgaacac gatggctacg gcaacaaacg gccagatggc 3212701 tttgacaaat ttcatcttta tcactccgat tatttagatt ttagtttgtc actatgatca 3212761 atatcaaacg tcagttttcc gtcttctact ttccaagcga aattagagtc tttcgtcagt 3212821 tcgcgaataa tggttttctg tttaaggctg tcttttttca caggcgcagg tgtcgcttca 3212881 tggatatcga tcggtgtcac ttcaaagcgt cctgttccat ttttcttcag gtgatactga 3212941 accagtgcac tgtctcttgt tctcgtccag ccttggtcaa agacaaagtt gccgaggctg 3213001 tagaaaatga cggttccgtt atatacttca atcggttcta agacgtgcgg gtgatggccg 3213061 acgatgatgt cagctcccgc atcagacatg gctcttgcaa gctggcgctg gcggtcattt 3213121 ggatcattgt catactcttg tccccagtgt gactgcacaa caacaatgtc cgcatgtttt 3213181 ttcgcttctg aaatcatagg gatgaagatt tcaggatctg cgggcagcac gcccggcgta 3213241 ttctttttag ccgcgaaacc tttcccggac acatcggtaa agccaagcgt cgcaatcgtt 3213301 accccgttga ctttctggta cgaaattttc tttttcgcat cacttaagct gtatcccgct 3213361 ccaacgatat caagattttg cttcgcaaat tctccaagcg tatctttcat gccctgaacg 3213421 ccgtaatcca ttgcgtggtt gttggcgctg ttgagaaccg tgaaattcat atccttcaag 3213481 actttcactg attccttatt cgtctgcaga tgaatctctt tatctgcttg tttataattc 3213541 ttttgatagg ttaccgggtt ttcaaagttt cctgctacat aatccgaggc tctaaagatc 3213601 ggttcaacat attgaaaaat actgtctgcc cctttttgct ccgttacttt ttcaacatag 3213661 cgtcccatca taatatcgcc tacaaatgag gctgagagta cgtcgtcaga atacgttttg 3213721 accttcggcg tttccgcttt tcccgcccac atgaaagcga acataaggac aaaaacgatc 3213781 ggaatggcaa taaatacgtg cttattggtt ttcttttttt gctgttttgt cagctttagc 3213841 agcttttcat gaaagctcag ttcttttttc atcgtttgac acaccttaca ttaaattaag 3213901 tagtaaacaa acatgatagc aaaggtcgct ccgctcaata gcagcgtgct tccgaacgta 3213961 atggttaaac cttgtttctg aatggtattg gcaattaaac ctggcacgat gatgccgatt 3214021 cctcgaaatt ctgcgatttc aaatggtaca atcgggtata gaaaatcaaa cgcgattttt 3214081 aggacgatcc ctgttatcag catggcagcg aattttctgc gtccgtacaa aatcataaat 3214141 ttggataaac cgtatttcac aatgacatac gtgagcaagc tcactagcaa aacaagtaaa 3214201 ataaagaccg gctgattaaa cacaagtcct aaatatcccg gtacaacaag tcctgccggc 3214261 acgatccctg ttttttccgc aaaaattaaa ctgagtagta cacctaaaat tagtgcgatg 3214321 tataaatctg atccgaacat gtctgcattt ccccctagct tacgagctgc tttaccttgt 3214381 attcgtggat tttttcaatt aaaggctctg cggcaccatg aatattgccg acgccatata 3214441 tgacacggtt gtgcattctt ttctttaaca attccataat ttcatctgtt gacttatact 3214501 ctagatcatg cagtttgtct gcaggaattt tgccttcttc gtaggctttt acgatcggtt 3214561 ctgttgtttc accgattaag atcagttcac ttgcttcaat ataaggcaat acgtcatttg 3214621 cgaattgctg tgtccgatcg acacggtctg cgcggcagtt catgatgatg atcggatcat 3214681 cggtcgggta accgatttct tttacacgtt tccatatatt caaagtagaa gaagcgtcgt 3214741 ttgcggcaaa cccattaaca aagtgcccag gctcgctcgg actgatcagc ggaagaattc 3214801 tcattgctcc cggatctggc ggcgcattca gcattccctt aaatgctgtt tcttcgtcaa 3214861 tgccgagtgc ttgagccaca cccagcgcca gagaagcgtt atcagggaat accatgtatt 3214921 caaatttacg taaatactca tctgtaattt ttgagttatc agcaatgatg acttttgtgt 3214981 ttcgttcttt tgctttttgt ttaaagaact cggtatattc actatctgta atgacaagat 3215041 ggccattata aggaattgta gcagtaaacg cttctgcaat ttcatcaagc gtcggcccca 3215101 tgacatccat atggtcttcc aaaacattca caatgacgcc gatattggcc tgcagaagtt 3215161 cttcctgaaa gatgatttga taatctgggt taacagccat gcattcactg acaatcgcgt 3215221 tagcccctct ttctactgtt tctctcatga cttctttttg ctctccgata ttcggcccct 3215281 gaggtttccg tttaatcggc ttttcctccg gtgtgtccca gtaaatcatt cttgcatctg 3215341 ttcctgttgt ttttccaaca gtcttgtaac cggcttctat taatattccg gttgtcagcc 3215401 ttgtcacagt cgattttccg cggatgccgt taatattcac ccgaacaggg agggcatcaa 3215461 tgtttttctg atgtcgtcgt ttttctaata ttccgatgac cagtatgaca gcacaggcta 3215521 taatgagtaa ccacattgct tttcgacatc tccttctata ttgttgtaaa ttcattcatc 3215581 agtatataga atcactatga attctcaatc ggcattatgt aacataatct tccctaatcg 3215641 actaagccaa acttctcttt tgaaagagat tttataccta caaactgttt tctatttttg 3215701 gaaaacagca ggacttatac cttatcactt tttaaaaaaa tcaaagagaa tgcgctttca 3215761 tttttctcct gatatccttc tggacgtata gtcacaccct gctgtttgta tttaatatgc 3215821 atttcaaatc aatctttttt tcagcctttg ttatcaagca tttcctgcta tcatgcgtgt 3215881 ttccggttct tatgaacaca aaataatttt atcctgtttc ttaaggacaa ggtcataatg 3215941 tcatcctttc tgcatggaat aagcaatatg aggcccattc caaaatgact aaggaggttc 3216001 gagatgaaaa cgctaaacat acgagtccga attctctaac ataattaaac attttctggg 3216061 atgatagtct tttctgtttc tccccattta caggtctaaa cgcatgactt tgaaacaatt 3216121 ttaataaaac ttaatatttg ttcaagaaat cttcatccat atttgtgaag actttgtcaa 3216181 aaaaagagtg aaaaccttaa atttttcaat tatatataca atttacaatt agatttcttt 3216241 tgatattttt attgctaact tcggattgtt catgataatc tatctatgta aacggttaca 3216301 taaacaagga ggagctgttt tggctacaat taaagatgtc gccggagcgg cgggcgtttc 3216361 agttgcgacg gtttcccgca acctgaatga taacggctat gtacacgaag aaacgcgaac 3216421 gcgtgtcata gcggcgatgg cgaagctgaa ctattacccg aatgaagtcg ccagatctct 3216481 atataaaaga gaatcccgac tgatcggact tttgctcccg gatatcacaa accctttctt 3216541 cccccagctt gcccgcggtg cggaggatga attgaaccgg gaaggctatc gccttatttt 3216601 cggcaacagt gacgaggaat tgaaaaaaga acttgaatac cttcaaacct ttaagcaaaa 3216661 tcatgtcgca ggcattattg ccgcaacgaa ttacccggat ctcgaggaat acagcggcat 3216721 gaattatcca gttgtttttc tggacagaac gcttgaaggg gctccttctg tgtccagtga 3216781 cggctataca ggagtaaagt tagccgccca ggctatcatt cacggaaaaa gccagcgcat 3216841 tacgctcttg agaggacccg ctcacctgcc gaccgctcaa gaccgattta acggcgcttt 3216901 ggaaatctta aagcaggctg aagttgattt tcaggtcatt gagacagctt cattttcaat 3216961 taaagatgca caatcgatgg cgaaggagct gtttgcctct tatccagcga cagatggtgt 3217021 gatcgcgagt aatgatattc aagccgctgc cgttttacat gaagcattgc ggcgcggaaa 3217081 aaacgtgccg gaggacattc aaattatcgg ctatgatgac attccgcaaa gcggacttct 3217141 gttcccgcca ctttctacaa ttaaacagcc cgcatatgat atggggaaag aagctgccaa 3217201 actgcttttg ggtatcatta aaaaacagcc gctggcagaa acggcaattc aaatgcctgt 3217261 cacctatata ggaagaaaga cgacaagaaa ggaagattaa gatgcgtaat atttgtgtga 3217321 ttggtagctg ttctatggat ttagtggtca cctcggacaa acgcccaaaa gccggtgaaa 3217381 cggttcttgg cacgtcattt cagactgtgc cgggcggcaa aggagcaaat caggccgttg 3217441 ccgcagccag acttggggcg caagtgttta tggtcggcaa agttggagac gatcattatg 3217501 gaacagctat tttgaataat ctcaaagcta acggcgttcg cactgattat atggaaccgg 3217561 ttacacatac ggaaagcgga accgctcata ttgtgcttgc tgaaggcgac aacagcattg 3217621 tcgttgtcaa aggcgcgaac gatgacatca ccccagcgta tgcgttaaac gcgctcgaac 3217681 agattgaaaa ggtcgatatg gtgctgattc agcaggaaat cccagaagaa acggttgatg 3217741 aggtgtgcaa atactgccat tctcacgata tcccgatcat actaaaccca gcaccggccc 3217801 gcccgctcaa gcaggaaaca attgatcacg ctacctatct gacgccgaat gaacacgagg 3217861 cttcgatttt attccctgag cttaccattt ccgaagctct ggcgctttat ccggcaaagc 3217921 tctttattac ggaaggaaaa caaggcgtcc gctattcggc tggcagcaaa gaggtgctca 3217981 tcccgtcctt ccctgtagaa cccgttgata caaccggagc cggtgatacg tttaacgcag 3218041 catttgccgt ggccctggct gagggaaaag acattgaagc cgcattgcgg tttgccaatc 3218101 gtgccgcttc cctttctgtc tgctccttcg gtgcccaagg cggaatgccg acaagaaatg 3218161 aagtagagga gctgctgtca tgaaaaaaca cggtatactg aacagccatc ttgccaagat 3218221 tttagccgac cttggccaca ctgataaaat tgtcatcgcg gatgccggac tgccggttcc 3218281 tgacggcgtt ttgaaaattg atctttcact gaagccgggc cttccggctt tccaagatac 3218341 agcggcagta ctggctgagg aaatggcggt cgaaaaagtc attgctgcag ctgaaataaa 3218401 agcatccaat caggagaatg cgaaatttct agaaaatctt ttctctgaac aagagattga 3218461 atacctttct cacgaggagt ttaagctgct gacaaaagat gcaaaggcag tcataagaac 3218521 aggagaattc acaccatatg ccaactgcat cctgcaggca ggtgtacttt tctagaaagg 3218581 aagatgaaac atgcagattg aaatgaaaga cattcataaa acattcggaa aaaatcaggt 3218641 gctgtcaggc gtttcctttc agctcatgcc tggcgaggtt cacgcattaa tgggagaaaa 3218701 cggcgccggc aagtccacgc ttatgaacat tttgacaggc ctgcacaaag cagataaagg 3218761 tcaaatcagc ataaacggaa acgaaacgta tttttccaat ccgaaagaag cggaacagca 3218821 tggaatagcc tttatccatc aggaattgaa tatctggccg gaaatgaccg ttcttgagaa 3218881 tctatttatc ggtaaagaga tatcctccaa gctgggcgtt ttacaaacaa gaaaaatgaa 3218941 agcgctagca aaagagcaat ttgacaaact ttccgtctct ctttctcttg atcaagaagc 3219001 cggcgaatgt tccgtcggac agcagcaaat gatcgaaatt gcaaaagcgc ttatgacaaa 3219061 tgccgaggta atcattatgg atgaaccgac cgcagcgttg actgaacgtg aaatcagcaa 3219121 gctctttgag gtcattacag cgttaaaaaa gaacggcgtc tccattgtct atatttcgca 3219181 tcgcatggaa gaaatttttg cgatttgcga cagaattacc atcatgcgtg acggaaaaac 3219241 ggtagataca acaaacatct cagaaactga ttttgatgaa gtcgtcaaaa aaatggtcgg 3219301 acgggagctg actgaacgat atccaaaacg cactccttct ctcggtgaca aagtattcga 3219361 ggtgaaaaat gcttccgtaa aagggagttt tgaggacgtc agcttttatg tgcgttccgg 3219421 tgagatcgtc ggtgtttcag gattaatggg agccggccgg acagaaatga tgagagcgct 3219481 gttcggcgtt gacaggctgg acacgggtga gatatggatc gctgggaaaa aaacggctat 3219541 taagaacccg caggaagccg tgaaaaaagg tctcggcttt attacagaga atcgcaagga 3219601 tgaagggctc ctgctcgaca cctcgatccg cgaaaatatt gccctgccca atctgtccag 3219661 cttctcacca aagggtctca ttgatcataa gcgggaggct gaatttgtcg atctgttaat 3219721 caagcgcctc actatcaaaa cagcatcacc ggaaacgcac gcacgccatt tatcaggagg 3219781 aaaccagcaa aaagtggtga tagccaagtg gatcggcatc ggaccgaaag tgcttatctt 3219841 ggatgagcca accagaggtg tggatgttgg cgccaaacga gagatttata cgctgatgaa 3219901 tgagctgacc gaacgcggtg tcgctatcat catggtgtca tcagagcttc ctgaaattct 3219961 gggaatgagc gatcggatta tcgttgtcca tgaaggcaga atcagcggcg aaatccatgc 3220021 gcgagaagca acacaagaac gaattatgac acttgccacg ggagggcggt aatatgaaaa 3220081 cggaacaact gcaaacagaa caaaaacgga ttcacttcga cggagtcatg caaaaactcg 3220141 gcccgtttct tggtttattt attctcgtta tcattgtatc tattttaaat cccagctttc 3220201 ttgaaccgct gaatatttta aacctgcttc gccaggtcgc cattaacgga ttaatcgcgt 3220261 tcgggatgac ctttgttatt ttgacaggcg gcattgatct ttctgttggc gctattcttg 3220321 ccctgtccag tgctttagtt gcggggatga ttgtgtccgg tgtcgatccg gttctcgcga 3220381 tcatccttgg ctgtatcatt ggtgccgtac taggcatgat caacggatta ttgattacta 3220441 aaggaaaaat ggcgcccttt atcgccacgc ttgcgaccat gactgtgttt cgcggactga 3220501 cgctagtgta tacagatgga aatccgatta ccggacttgg cacaaactac ggttttcaga 3220561 tgttcggacg cggttacttt ttaggcattc ctgtaccggc aattacgatg gttcttgcct 3220621 ttgtcatcct ttgggtgctt cttcataaaa caccattcgg acgccgaacg tacgctatcg 3220681 gcggcaacga aaaagccgcg ctcatttcag gcatcaaagt gacgcgcgtg aaagtgatga 3220741 tctattcttt agccgggctt ttatccgctc ttgcaggtgc catattgact tcccgcctgc 3220801 attcggccca gccgactgcg ggagaatcgt acgaacttga tgctatcgcg gcagtcgtct 3220861 taggagggac aagtctttcc ggcggccgag gacgcattgt cggcacgtta atcggggtgc 3220921 tgatcatcgg cacacttaat aacggactta atctgcttgg cgtctcatca ttttatcagc 3220981 tggttgtcaa agggattgtt atcttaattg cggtattgtt agaccgcaag aagtcagctt 3221041 aggagggttt tacatgaaaa aggctgtatc cgtcatttta acgttatcat tatttttgtt 3221101 aaccgcctgt tcgcttgagc ctccccaatg ggcaaagcca tcaaactcgg ggaacaaaaa 3221161 ggaattcacc attggcttgt ccgtctcaac gcttaataat cctttttttg tctcattaaa 3221221 aaagggtatc gaaaaagaag ctaaaaaacg gggaatgaaa gtcatcattg ttgatgcaca 3221281 aaatgattca tcgaaacaga cgagtgacgt ggaagattta attcagcaag gtgttgatgc 3221341 attattaatc aacccgactg attcttcggc gatctcaacg gcagtagaat ctgcaaacgc 3221401 agtcggtgtg cccgtcgtaa caatcgatcg atctgcggaa caaggaaaag ttgaaaccct 3221461 cgttgcttcc gataatgtaa aaggcggtga aatggccgcg gcgtttattg ccgacaaact 3221521 tggaaaagga gcaaaggtgg cagagcttga aggcgtcccc ggcgcatctg ccacacggga 3221581 acgcggctca ggattccata acatcgcaga ccaaaagctc caagttgtca caaaacaatc 3221641 agctgacttt gaccgcacga aaggcctgac tgtcatggaa aacctgctgc agggacatcc 3221701 tgatatccaa gctgtttttg ctcacaacga tgaaatggcg ctcggtgctc tcgaggcaat 3221761 taacagctcg gggaaagaca tattggtgat cggttttgac ggcaataaag atgcgctcgc 3221821 ttccattaaa gacagaaagc tgtcagccac cgtcgctcag cagcctgaat taatcggtaa 3221881 attggctaca gaagcagcag atgatatttt gcacgggaaa aaagtgcaaa aaacaatatc 3221941 cgcgcctctc aaactagaaa cacaaaaata attgtctgat gtttaggaac ctgcgataac 3222001 gtgaatagag atatagaatg aattatttct cttacgtgag gagaggaacg gcatgaacaa 3222061 accaacaaaa ctattttcaa cattagcact tgcggctgga atgactgcgg cggctgctgg 3222121 cggcgctggc acgatccatg ctcaacagcc agaaacaacg gtaagcattg atgatttata 3222181 cagttatccg attgattctt atttggtatc agcagaggct ctaaatgtca gaacgaagcc 3222241 ttccgcatca agccagaaag ccgatacgct gcacttagga gatagcctaa agctgatttc 3222301 cttctcaaat gctgactggg caaaggttaa gtataaaaat ggaaaaacag gatttgtatc 3222361 cactcattac attgttaaag cagcgacaac ggtaaaaacc aaaacaaaaa caaaagtgta 3222421 tacatccgct gacggaaaga gcattaagac tcttccagca gacacaagcg tttctttttt 3222481 aggctggagt aaaacgaata aaggcggttt tgattttgat tgggtattcg ttgattacgg 3222541 cggtacgaca ggttatatga aaacaaagga tttacacatg acaaaataac tgagagggat 3222601 tccgcataaa tgcggaatcc cttttattat gaattgattt gtcacattcc caagatattt 3222661 ctcaggaaat attgtcgtat gctgtgtcga aaccttacat gatcatcgac atttttgttc 3222721 acgctaaaaa gcggaggtgt aaatatggat caatttgaag cagcatatga atcgtataaa 3222781 gcccggcaaa caactgccga tcaagaaaat gttccatctg gaaaagaaga aattattgcg 3222841 gttagaagaa atgaggaaga caatattatc gcagtgaaaa ccaatacagg aagagagctc 3222901 gactacccta ctgcgctgtc agaagcaaaa tcaggaaaac tcgctcatgt tgatgtcttc 3222961 cataaatacg ggcgtgacat tttgcgaagt gaaccggacg gcatcaagga aaataacctg 3223021 tctgagctgc cggattttta aacaaataca gccctgccgt atgttggaca gggctgtatt 3223081 ttaaacaaaa ggctgctgga tgtattcggc taaccgtttt gcactgtgag aaatatcctc 3223141 tgcagctgca taattcacgc catagaacac atatggaggc agatacttca tgccgatcag 3223201 attactcgtg gcctgaaatg gtttcaatag ctcactgatc gagtaatgat ttgctccgcc 3223261 cgcttgatat ttttccgctt cgctccctgt tgatacagcc agcatcagct ccttgccatg 3223321 caaggcattt ccttctgaac caaaagccca gccataagtc agcacaagat cctgccattt 3223381 tttcaagagc ggcggagagc tgtaccaata tagcgggaat tgaaagacaa tccgatcgta 3223441 ttcctcgcac agctgctgtt ccttcgcaac atctatcgct tcatccgggt attccttata 3223501 aagatcccgt actgtgatat tgtcatgttt actcaattcc tcagcccacg ccttattaac 3223561 aactgaggtc tccatatgag gatgcactgc caaaaccaat attttcatca gaccacacct 3223621 ttactgtttt gatgttattt tatctaaaat caggaaaaga gccaaataaa aagaaagccc 3223681 tgctaaaagg ggctttcttt ttttctttta ttcagggctt ccttcagttg tttcgatatc 3223741 tttcgcaaaa tcagggttat ccagattcgc attaaagaaa tccgctgtgt tcggaagtct 3223801 gagattcatg ttcatttttt gagaaatcgt aaccgtgcaa tcctcaagca catagtcaaa 3223861 aacgtgtccg cctgaattgc gtccttcgtc aatgaagtgc aggtgatagc cagaaacggc 3223921 gattccgttt gcataagctg gtgtcaagaa acctacaatc gttcctctca cgttgtcgaa 3223981 gttgaaaatc ggctgtgttt tgaccgcttc aaccattggc acgtaaggtt tttcttgaag 3224041 ttctactgtt cttgtctgca cctttttaaa caatccgtca atgcgaattg cataaaataa 3224101 gtttctgctt ggcagcatgc tgttgatctc tttttcaaag tcttcgcgtg tcattttcgc 3224161 atcaattttg tgcgtcatgt ccggtgtaaa gaacgtaaat gaacagaacg gtgaacggtc 3224221 tccattttgg accggtgtcg cggttccgtc tgagcgaaga cggtaaaatt cgccgtcaaa 3224281 cccaatcagc tctccgtcaa gcttgttaaa ggttccgata ccgaagtctc catatttcgg 3224341 aatctctgac agttcaaaat ctccgtcata tactccgtct aatagagaag tcattgttga 3224401 tacttgataa atctggctca caggctgatc tttttgacca cggctgagca cttgaatgtt 3224461 gctttctcgt ttcatatttc ccttcactcc ttttatttag tgctgttcat aaaacagtgt 3224521 cgtgatgcgc agagtgctag agagctttcg ttttcatgag ttccccgaat tctttcggaa 3224581 gcttgtcact tgctaaatta atgttatcac tgtagtcaac cgggacatcg atgatgacag 3224641 gaccttcagc gttcatgcct tgacgcagaa catctgccag ctggtctggt gattctacgc 3224701 gcaagccagt tgctccgaag ctttccgcat atttcacgat atcgatattt ccgaaatcga 3224761 ccgcagatgt acggttatat tttttcaatt gctggaatgc aaccatgtca tatgtgctgt 3224821 cgttccatac aatgtgtaca attggtgctt ttagtcgaac tgctgtctct aattccattg 3224881 ctgagaataa gaaaccgccg tcaccagaga cagaaaccac tttttctccc ggtttcacca 3224941 atgaagcgcc gattgcccaa ggaagcgcaa cgccgagtgt ttgcataccg ttactgatca 3225001 ttaatgttaa cggctcgtag ctgcggaaat aacgtgacat ccaaatggcg tgcgaaccga 3225061 tatcgcaagt tactgtaaca tgatcatcga ctgcattacg caactcttta acgatttcaa 3225121 gagggtgcgc tctgtctgat ttccaatctg caggcacctg ctcaccttca tgcatatatt 3225181 gttttaaatc agaaaggatt ttctgctcac gctctgcaaa ttccactttc acagcatcgt 3225241 gttcgatatg attgatcgtg gacggaatgt caccgatcaa ttcaagatca ggctggtaag 3225301 catgatcaat gtcagcgata atctcgtcta aatggataat tgtccggtct ccattgatat 3225361 tccagaattt cggatcatat tcaatcgggt catagccgat cgtcagaaca acatctgcct 3225421 gctctagcag taaatcgcca ggctggttgc ggaacaaacc gatacggcca aaatattgat 3225481 cctctaaatc tctagaaagg gtaccggcag cttgatatgt ttcaacaaat ggaagctgaa 3225541 cctttttcaa aagcttgcga accgctttaa ttgcttccgg tcttccgcct ttcatgccga 3225601 ccaaaacgac aggaagtttt gctgtttgga tttttgctat ggccgcactg attgcatcat 3225661 ctgctgcagg accgagtttt ggcgctgcaa cagcacgcac gtttttcgta tttgtgactt 3225721 cattcacaac atcttgcgga aagctcacaa aagcggcccc agcctgccct gctgacgcta 3225781 tcctaaatgc atttgtaaca gcttccggta tattttttac atcttgaact tctacactgt 3225841 attttgtaat cggctggaat agcgccgcat tatccaaaga ttgatgtgtc cgttttaaac 3225901 gatctgcacg gatcacgttt ccagcaagcg caacgacagg gtctccttca gtgttcgctg 3225961 tcagcaggcc tgttgccaag ttagaggcac ccggtcctga tgtgactaac acgactcccg 3226021 gttttccagt taaacggccg actgcttggg ccatgaatgc tgcgttttgt tcgtgccggg 3226081 caacgataat ttcaggtcct ttatcttgta aagcgtcaaa taccgcatca atttttgcac 3226141 ctggaatgcc aaatacatgt gtgacacctt gctccactaa gcaatcaaca acaagctccg 3226201 cccctctgtt tttcacaagg gatttttgtt cttttgttgc ttttgtcaac accctcactc 3226261 cttattatgc attttaaacg taaaatttta aatatcttgt gataagtttc actatacact 3226321 ctttggaaat tgacctccaa tatcgattcg ccttatgatt aatatgtaat acgaattatt 3226381 aacctatgga aaggaatgca tattgaatgg agcttcgcca tcttcaatac tttatcgcag 3226441 tagccgaaga gcttcatttc ggaaaggctg cccggcggct gaacatgacg cagcctcctc 3226501 tcagccagca gatcaaacag ctggaggaag aagtcggagt tacgcttctg aaaaggacaa 3226561 aacgatttgt cgagcttacc gcagcaggag aaatcttttt aaatcattgc cgcatggcat 3226621 tgatgcaaat cggacaagga attgaactgg cacagcggac ggcccgcggc gagcaaggcc 3226681 ttctcgtaat cggttttgtc ggatcagcta catatgaatt tctgccgccg attgtccggg 3226741 aatatcgtaa aaaattccca tctgtgaaaa tagaactgcg tgaaatatcc tcgtctaggc 3226801 agcaggagga gctactaaag ggcaacattg atattggtat acttcatcct cccttacagc 3226861 atacagcttt acatatcgaa accgcccaaa gcagcccttg tgttttagct ttgcctaagc 3226921 aacacccatt gacttctaag gaatcaatta cgattgagga tttaagagat gaaccaatta 3226981 ttactgttgc taaagaagca tggcctactc tatacatgga ttttattcag ttctgtgaac 3227041 aagcgggctt cagacccaac attgtccagg aagccacaga atatcaaatg gtgattggtt 3227101 tagtcagtgc cggaattggt atgacatttg ttccttcctc ggccaaaaaa ttatttaatt 3227161 tggatgttac ttatcgaaaa atggaccaaa tacagcttaa tgcagaatgg gttatcgctt 3227221 accgcaaaga caatcataat ccgcttataa agcattttat tcatatttca aattgtcagc 3227281 agacaagaac taaagagagt gatgcaggta catgaacaat acttgcaatc tcttttttct 3227341 tttgggattc ttatggaatt tttattaatt taatataatc gcttagtaca actttatatc 3227401 agtatacgta tacatacagt acaaatagtt ggcaaggaca tcagtaagcg caggacatta 3227461 gtttgatttt aaaaatgaaa gatagagagg tgaagtaaat tattgagttc accggcatat 3227521 tcacattgct cgcttttttc gtaacaatga tttttatttt ctggagacca aaaggactaa 3227581 atgaagctat ccccgccaca tttggcgctt taatggtttt attgtgcgga agtgtgtcat 3227641 tggcagactt aggggaaatc ggaacaaaag tcacgggtgc atcggttaca atccttgcca 3227701 ctatgattat ggccattgca ctagaaagct ttggtttctt ttattgggtg gctgcaaaac 3227761 tgctccaaca atccaagggt tcaggcatca agcttttttg gctaaccaat ttgctctgct 3227821 ttctcatgac cattttcctt aataatgatg ggagcatttt gatcacaact ccaatccttt 3227881 tgcttgtact aaaatattta ggtttaaaaa aacatcaaaa agccccatat ttattaagcg 3227941 gtgttttaat agccacagcc tctagcgcac cgattggcgt aagtaatatt gttaatttaa 3228001 tttctctcaa aatcattgga atggatctat atcttcacac cgccatgatg tttgtcccta 3228061 gtatgatggg actcattttt atgacttgtc tactgtttat gttcttttat aaacgtcttc 3228121 ccaaaagcct gccagatata ccgggccatt ttcagtctct gcggcataga aggtaccatc 3228181 ctcttcattc gccatcagct cctttaccag aacgaaatca aacaaaaatc atgttgtttg 3228241 tgcttgcatt tgtttttctc gtcagaatga gtctatttgc agcatcatat accggtattt 3228301 ctgttcctct agtcgctgtc atcggatctt ttatcctgtt gagctggaga tggatttatt 3228361 tcaaaacctc cccaagagac ttgttatata aatcgccttg gcacattttt atattcgctt 3228421 ttactatgta tgtcttaatt tatggtctgc ataatattgg attcacagag ttacttgtga 3228481 gttattttga acctgtggtt tctggaagcc tcgcccatgc aactttcgca tcaggtatct 3228541 ctacttcagt tttttctaat ctctttaaca accatccagc gttaatgatc agtactttta 3228601 ccttaactga aatgaccctg aatccttcaa caacaaaaat catctacttg gcaaatatta 3228661 tcggcagtga tatcggttca ttattattac ctatgggaac cttagcaacg cttatttgga 3228721 tgcatatatt aaaacagcat gatgaaagta tttcatgggg cgaatatata aaaacgacca 3228781 ttatcatcat tccgctgact gttcttttta cgttaacatg tttatatttt tggatcagtt 3228841 ggttatttct ttagcacagt atgaaacgaa aaactgcctt ctgcttttca agagggcagt 3228901 tttgtataca ctagggaaga tgcattgtct ttagatgatt taacttccaa atgactggct 3228961 ctccacttgc gttaataagc tcaatgatat tattagagac accctttaat agtccgactt 3229021 tttctggcac ctctcccata tcaaatatga ccaattcacc aatatttttt ttgatctgct 3229081 cctcaaaatt acgcacaaga ggaactttgg aaggcacgac cggcaattgt gagttgtcaa 3229141 gagtatacgg tgtttgttca gttgaataag gggtaaacca ttttaaatga tgcatagata 3229201 taaaaagtat tttaaatacg ggtgagaaaa atacaatata atcgtttaaa acatttgtaa 3229261 catatccatg gatcgatcga cccccagtta cataaacttc aataaactgg cctttgacct 3229321 tgtttaatgt atttctatat gaaaaagctt gagtttctgc ctctatcatt ggatcttccg 3229381 gattgatcaa aaatggcttc tcagtactgg tcactatttt cgccttgttt atttgatgaa 3229441 gatgcaacaa gggaatataa agataattgc agccatcaaa aataacaaaa atatcctgtc 3229501 cgatatctat gagggtgccg acaaaccttg tatctcctga aatgacaacc tcaacatctg 3229561 tgttaaggaa ttgattcaaa cctttcacga ttctcctcct ttaactgaaa aagggcatca 3229621 ctttatctga tgctcctcca ttatctatta aaatttacgt ttccagtgat agtctatcgt 3229681 tctgacaatc gtttcatagc tataatcttc cttttgtttt cctgaacttt ttattgaact 3229741 tgaatagcct ggtgatcttg atgattgata atctgaagat cttggtgatc gtttagatga 3229801 ttttgatgat tgataatctg aagattttaa tgatcgttta gatgattttg aagaactttt 3229861 tgaacgtgac gaacggccag atttggatga ttgataatcc gaagatttta gtgatcgttt 3229921 agatgatttt gaagaacttt ttgaacgtga cgaacgacca gatttggatg attgatcatc 3229981 tgaagatttt agtgatcgtt tagatgattt tgatgagcta tatgattttg aagaaatgaa 3230041 cgaattgctg tccttatcat tattgtcttc ctggttttgt tcattttttt gatcctcttt 3230101 tttgtacgac ccttttggac ctaagctgat gctttttatg tgaaaaggat agatgcgaag 3230161 cacctcttga tttttcacta tagtataatg gccgtcggca ttatctacaa ggataccctc 3230221 aatggcttcc ggacctccac gattaattga aacccattta tgagtcagac tcttaaaaac 3230281 ctcgcttaaa tcatcagctt ccaaaactcc aactggcgtc tgctcttcta ttttcaaatc 3230341 aggctcgtgt ttacttatac ttttgatgtg atggatatta aaatacacta ccccatcctc 3230401 atttgtgttt aacgcagcgt aatcatctcc cagccagacc aatcttcctt ttttagattc 3230461 cggaccccct tggttaaatt gaactgattg gtttattaaa tgtccgatta agctatgaaa 3230521 atcatcagca tcgagcattt cctcagtctc aattgttgtg gtgctattat tggtatcctc 3230581 agtaatactt ttcacatgct ccaactgata ataaattatt tttttttcag cttgtaaagc 3230641 tatataatct gattttacag ctgttaattt tcctttttta gattccggac ctccacgata 3230701 tacagtaaca attttatctt tcattgagtg caaaaagtta taatacgata tttcattatt 3230761 tgaatgatat ttcattctcc tcttgctcat tcaaattcct cctagtcact tatacataga 3230821 tgataaacat actgcatata tacgtgtcac atttatttgt tgaactaatt caatagccta 3230881 attgtcgctt tttccgcgaa tacccatttt cacgcattca taaaatactt aaatgatctt 3230941 tgaggtattg tgaacggttt ttaatatact cgcagatcac atccggctca cggtcaaaac 3231001 gctcaatatc attcttttta tacgggtcca tgaggacaaa cggcctaatc cgttcataca 3231061 tcgccatgat tttcggttcc atatattcta ttgtaaaaag agattggagc gttttttcta 3231121 acaggcgctt gtaggacttg cgaaactcgg attcatccaa tatccgggcg gttagtgtat 3231181 taaatccttg aattcttaca taatcggcag ccatccgctc tccatggata tccctgcccc 3231241 aagtcgcatc ataatcccaa ggaatcacct caaataatcc ggtttccccg cttctgtata 3231301 atgcgtagtt gtggacaaac ccgtcatagt tcgaggtgaa tacaatacca gcaagccagc 3231361 gcaaatactt atcgacatcc acgtgttttg tcacttctga cttaaactga gctttaggga 3231421 ccgtattaat tttaaaaatc atatcttgta aataaaaatc atcttcctca gtccctgttt 3231481 tcttttcata tccaagctcc agcgatgttt tcgtttccct ttctaaatcg ctcatcagag 3231541 aaaagttggc atcatcatcc accgcataaa aaatcgcgcc atcagccagc ttccttttcg 3231601 ccaaataata ttcatctacg gattcaagtt caagataaac cccttcattc ttcccattca 3231661 tctttacaaa cgcaaactct gcctttggag acagtgtccc tagctccgag aaaaaatcca 3231721 gagacaattt gtttctcatc aaggaagggt ctttatactc cgcatttaag tgaatctctc 3231781 gcgcgccgcg gaatgttttc ggctgataaa aggaaatatg gtatgacttc tttttgaagt 3231841 ctctgatatg tgatccccga taagcgatat caatatccag ccttttttga tttaccttca 3231901 tcacagctgg caccggatca tcgtcccata tatccttttt taattcacgc aagtcttttg 3231961 gatgaacaaa cagctgataa agcggtaaat tggattgatt cttcatccat aatcctcctt 3232021 acaaatttta ggcttttatt tttataagat ctcagcggaa cacttataca ctttttaaaa 3232081 ccgcgcgtac tatgagggta gtaaggatct tcatccttaa catattttta aaaggaggat 3232141 ttcaaattgg gccactattc ccattctgac atcgaagaag cggtgaaatc cgcaaaaaaa 3232201 gaaggtttaa aggattattt ataccaagag cctcatggaa aaaaacgcag tcataaaaag 3232261 tcgcaccgca ctcacaaaaa atctcgcagc cataaaaaat catactgctc tcacaaaaaa 3232321 tctcgcagtc acaaaaaatc attctgttct cacaaaaaat ctcgcagcca caaaaaatca 3232381 tactgctctc acaagaaatc tcgcagccac aaaaaatcgt accgttctca caaaaaatct 3232441 cgcagctata aaaaatctta ccgttcttac aaaaaatctc gtagctataa aaaatcttgc 3232501 cgttcttaca aaaaatctcg cagctacaaa aagtcttact gttctcacaa gaaaaaatct 3232561 cgcagctata agaagtcatg ccgcacacac aaaaaatctt atcgttccca taagaaatac 3232621 tacaaaaaac cgcaccacca ctgcgacgac tacaaaagac acgatgatta tgacagcaaa 3232681 aaagaatact ggaaagacgg caattgctgg gtagtcaaaa agaaatacaa ataatctaag 3232741 ttttcattgt ttcaataggc tgccggcgga ggtacggaag cctatttttt tatttgccct 3232801 gtattagata tatgtcatga cataacatat gcaacccgca tcatttggtt tcctttaaac 3232861 catttcgtta taatcaaggt atcctaacga taaaggcggt tgttgctatg tacatatttc 3232921 aagctgatca gcttagtgcc aaagacacat acaagctatt gtcaggtacc gttattcccc 3232981 gccccattgc atttgtgaca acactttctt caggaggagc ggtaaatgcc gcgcctttca 3233041 gtttttataa cgtcgtcagc tcagatcctc cgcttctcag tatttctgtt aacaggacgg 3233101 aaggacgcca aaaagataca gcacgaaacg cagtggagaa cggagaattt gtcgttcatg 3233161 tcagtgatga agccatcatt gaagatatca atgaaacagc tgcaagctta aggccggatg 3233221 aaagcgagct tacacgcacc tcgcttcatc ctgttgaaag caaagctgtt tcagttcccg 3233281 gcattaagga agcccgcgtt cgctttgagt gcaaattaga gcggcatatt acctttgaca 3233341 atgatcaagg catcactaca gcagatctgc tcatcggaag agttgtctgc ttccacctag 3233401 atgaaaaggt gtatgatgca gaaaagggat atattttaac ggatgaatta aagcctgcct 3233461 cacgattggc gggaaatcac tatgccaagc tgggggaaga attcacactg attcgtccca 3233521 gctgaagaga aggactattt aaatagaaga aactagtcaa aaagacctta tgattacaaa 3233581 atatcgcctg taaataactg aaaaaatatc aaaaaaaaga acacccagag caagctcggg 3233641 gtgttctttt atgaaacgtt tttccttttt cttcgtataa aggtagatta ggaggaattg 3233701 gaatgacaaa cttttggatt ttaatgctga tcgctattac catcagtctc gcctctcaat 3233761 tttttataaa gaaaaaatac ggtattgata aatccggctg gcgatataag catgtcagca 3233821 atacacacaa atggatcgaa atcactttac ttattttgtt tgtgttttca ctctcctttt 3233881 ttccagttga atatttgctt cttttatttt ttattgtgat tgactcaata cgtattttta 3233941 tggagtggca ttatagacct gaagataaac agtatatgta ccacattgta gaggtctccc 3234001 ttatgtttat gcttttgatt tatgtttgta ccctatagtt atttaaatcc ccacagccgc 3234061 tccgtctccc cgaggatcgg ctccgccttg gagaaagcct tcttcatcaa ctttgattgc 3234121 agccgcttgt cccatcagcg gatcatagtc accgacaacc tccacgagat gcccgctgtc 3234181 tttcagtttt tggattgttt tgtctgtgaa tctgccctcg actctgagac cttcgtattc 3234241 ctctccccac gttctgcccc atacccagcg cggttcgctg attgcctgct gtggatgcat 3234301 tccgtagtcc agcattcggg taatgatggc cgtctgggtc tgcggctggc cttcgccgcc 3234361 ttgtgtgccg tacagaattt ttggctttcc gcctttacag accatagccg gcatcaacgt 3234421 atggaaggtg cgctttctcg gttcaagcgt gttgacatga ttttcatcca gtgagaaaaa 3234481 cgatccgcgg ttttgcagta atatgcctgt atcaccggca gtgactgccg agccaaattc 3234541 aaagtacagg ctttgaatga atgacactgc gttgccatcc gcatcgatta cggccgcata 3234601 tgccgtatca cttcccaccg gcctgctttc tgccggtatt gcgagatagc cgatttcttc 3234661 tgccaattgt tttgcataac gtttgtccaa aagcctttca agcggaatgt ctgcaaacgc 3234721 cggatcagtc aggacggcat cccgatctag aaaactcttt ttcaatgcct ccacaagcac 3234781 gtgataatac tcaaatgaac cgtgttcgat ttgggtgaaa tcatagtttt ccaaaatgtt 3234841 cagtgttaat aaaccggtaa atccctgaga attcggcggc gcctgataca cactgtatcc 3234901 tcgataatca cttgatacag gcgctgccca ctcaccccga tgcgctttaa aatcatcgat 3234961 tgtcatgtaa ctgccgttat tctgtaaatg tgagacaatc cgctgagcga gatctccttc 3235021 ataaaatgcg cttcttcctt tttcagcaat caagttcaga ctgtctgcaa gctctttttg 3235081 cacaaaccgc tctcccggga caggtgcttt gccccttctc gtgaagatgt cagccgtgta 3235141 aggcgtggaa gccagcagtt caatattctt ttctgtgtga cgacactgat cagctgatac 3235201 aggaaaccca ttttgggcat aatcgcgtgc gggctccaat acatctgcaa gagacagacg 3235261 cccgtactcc ttcaggaccg catcccagct atcaaccatt cccggcacgg taatagcact 3235321 gtcaattccc cgcagcggaa tcgcgctttt tcccttatat acatctctcg ttacgttttt 3235381 tcctgaacgg ccgctgccat tgtagacttt tactgccttt gtttcctggt gaaaggtcag 3235441 ccaaaaggaa tccccgccaa gtccggtcat atgcgggtac acaaccgcaa gacaagcact 3235501 caccgcaaca gcggcgtcaa acgcgttgcc tcccttatcc agtatgcggt ttccggcttg 3235561 agaagcgaga taatgcggac tgacgaccat ttgctttgta ccgatgacag atttgttcat 3235621 cacaagtccc cttttttaag aaattttctt cagtataggg agcctgattt ttcacatcta 3235681 ctgatccggc agaaaaactg acgaactttc ttcttttcgc aaataataag atattttcgc 3235741 attcatttcg aaaacaaatg aaaaattatt atttctatac gtaactttta tgataaaatg 3235801 attgctaaaa ggctacgaaa gcaggtggag caattgagtc atgaatatca aatccccaac 3235861 cttgtacttg atgagactga taaacaaatt ctcacgattt tgcatgaaga aggcagaatt 3235921 tcttatacgg atcttggcaa aagagtcgat ttgtcacggg tcgccgttca ggcccgtatc 3235981 aaccaattaa ttgaagccgg tgttattgaa aaattcaccg ctgtcatcaa tcccgctaaa 3236041 atcggcatcc atgtttccgt gtttttcaat gtcgaggtag aaccgcaatt tttagaagag 3236101 gtcgctctta agcttgagga agagcctgcg gtcaccagcc tttatcacat gacaggcccg 3236161 agcaagctgc atatgcatgg gatctttacc aacgatcaag aaatggaaga attcttaaca 3236221 aaacggctgt atccattgcg aggcgtcgtc agtgttgatt gccagatgct gatcaaacga 3236281 tacaaaagcc gtatgggaat gaagctgtaa aggagagaaa caaatgaaaa accatcctta 3236341 tcgggatatg acggccgcaa tggttcgcac cggcatatta gggttcggcg gcggaccttc 3236401 cgtgattccg ctgatccgcc atgaagcggt caataaatat aaatggattg acgatgatga 3236461 attcggagaa atattagcaa tcgctaatgc gcttcccgga ccgattgcca ccaaaatggc 3236521 tgcttatctg ggctttaagc taaaaggcac attaggtgca attgtggcga tcctcgccca 3236581 cattctgcct acatgtcttg cgatggtggg cttgtttgcg gctgtaaatg tgttaagcca 3236641 ttcagcaatt gttgcaggta tgattggtgc cgtcacgccg gtaattgcgg tcatgctcgg 3236701 aatcatggcg tacgagtttg gccaaaaagc gcttaaaggt ttcggctggg ttaccggcat 3236761 cctgtttttt atcatcgctt ttatcggcct gcaaacttta cagattaatc ccggcctggt 3236821 cattatcatt ttcttagctt acggggcgtt tcattttaaa ctgaaagaca aaatcacaaa 3236881 taaacattca aaagataaag gaatgtcagc ctcatgatat cgatctattt atttatggcg 3236941 ttttttatcg caaacctact gggatatggc ggcggacctg cgtctatccc gctaatgttt 3237001 gaagaagtcg taaacagata cagctggctc tcaaacgatc aattctcaaa tatgctcgca 3237061 cttgcgaacg cattgccggg cccgatcgcc acgaaaatcg ctgcgtatgt cggctacagc 3237121 gcaggcgggt ggcccggctt cctaattgcc ctgatcgcaa ccgtcgtacc gtcggcgctc 3237181 gcattgatcg tcctgctgcg catcatccag cgcttccgcc aatcacctgt catcaaaggc 3237241 atgacgctgt ccgtccagcc tgtcatcgcg gtcatgatgc tcattcttac ctggcaaatc 3237301 ggcgcagacg gcatcaaagc gatcggctgg gtccaatcga tcgtgattac gggaatttcg 3237361 ctccttgcca tgacaaaatt caaaatgcat ccggcatttt tgattattgc ggcgttttta 3237421 tatgggggcc ttgtgatccc ttatttatag aaaaaagcac ctggacaggt gcttttttat 3237481 tttagcccag aaatgccgtt tgatatgaca gctgtttctt ctcctgcgtc actcttgatc 3237541 atgtgcttga cttgcagcgt ggttcctgcc attctcacag attgcttcaa ctgggacgaa 3237601 ttggtttcaa cttgtatcca aacaggaggc tggaccttcc aaaataaata gagtgcaaga 3237661 atcagcaagc cagcaatgac cgacagcaaa aacttcatat cgcatcgctt cttttcagta 3237721 agcggctcgc agcggacagc gcctgatgat cacgaagaat atcgcctgga cgattgcctt 3237781 ctcccagcac atagccttta aaggacattc ccataaaatg aaaaatatgt tcgaattgct 3237841 gaatcagcgg cagccctttt atttttggat tgtctccgcc cactgctatt acatatgcct 3237901 gtttcactga catttgctgt ttaaaatcag gaaatctcgg atctctcaac gtctgtgacc 3237961 agcgatcaat aaacagcttt aatgtccctg acatgccaaa ccaataaatt ggggtggcga 3238021 atataagaat atggcactgc aatatccgtt caatgataga atcgtagtca tcttgaacag 3238081 gacgaaagcc gccttgggcg tgacgcagat cttcaattgg ttgaattgga tatttctgca 3238141 aataaatgtg ctccgcatcg aatccttgaa cagccttctc cgcaagaaca tccgtatttc 3238201 cgccagaccg agttccgccg ttaataaccg caattttcat gatgcatctg ctcctttgtt 3238261 tacgaatgat tttcttcatc atataatgga ttcatcaatc aatacagatg attatttcga 3238321 ttaatccaat cgctaaaacc gatttagaaa ggaagagaac aagtggaatt gaagcagctg 3238381 atcaccttta ttacggcggc tgaacatgta aacttcaccc taaccgccaa aatgcttaat 3238441 tatgcacaat caagcgttac ctctcagatc aaatcacttg aagaagaaat cggaacgcct 3238501 ttatttgaac ggctcggcaa gcggcttatc ttgacagaag caggaaaaac gttcaaatct 3238561 tatgcacaga agatcattgc gttaacagaa gaagcgaaaa tggccacaaa tcaagtaaga 3238621 gaaacaaccg gaaccttaaa aatcggggcg acggaaagcc agtgcacata ccgcctgccc 3238681 cctatcataa aagaatttaa acaggctttt ccccaagtaa agctcatatt caaaccatat 3238741 atctccaatg aacaagcgaa agaacagctc ttacagggcc agcttgatat caccttcatc 3238801 ttggatgtaa accggatgga agacgcactg cacgttgaat ctttgattca ggatgagatc 3238861 aaaatggtgg ctgctaatga ccatcctttt cctgcggatt taccagtaac attgaaggat 3238921 cttcaaaacg aaactcttct gctgacagag gacggctgct cgtaccgcac gctctttgag 3238981 aacaatttgc atgactccgg tatctatcct aacaaattgg aattcgtcag catagaagcc 3239041 atcaaacaat gcgtgatggc cggacttggg attggaatct tgcctgaaat gacagtaaaa 3239101 gatgatattg cagcaggccg gatgaaagaa ctcaattggc agagcgattg ccccgttttc 3239161 actcaattag catggcataa ggacaagtgg atgtctgcgc cattaaaggc ttttatcgat 3239221 ttgacacgga aaacattcaa ataaaacctc tccacaagga cgacaaggtt tttgagacca 3239281 gggcacacac atacaaaaaa aacacttgat gacttagagc cccaagtgtt acacgtgatt 3239341 tttctgataa aacgttcgca aaacatgcgt ctcaaggtca gccaggcgga cagggatcgg 3239401 cagcctgctt tcttgattga tcaagctcat cgtgatctga tagctgctgt ctaaatcaat 3239461 ataattaccg caagacaaga aaataggctt cacgtcccgc cgcgttcgca gcgcccgtcc 3239521 atatacctcg ccgtcaatga taatatcggt gtatgcgcct acttcaattt caggcgtcac 3239581 gaaatcgcag cctttgattt tgagataggt tttcgctatc ccaatcgtcg gcttgcccag 3239641 aaaaaaagcc gcatgggtgg caacgcccat atgattgtaa tgcagatatc cgttgccatc 3239701 aaacaagaag acatccggct ccgtctccag ctttttcgcc gcctcgatga tcaagggcag 3239761 ctcgcgaaac gcaagaaaac cggaaacata cggcacgctg attctcccca tgctgtgcac 3239821 tttttcaatg acttcttttg tatcagcgtc aattacgata atacagcaca ctccgtatgg 3239881 ttctccatcc tgctcccaat aggccaggtc gacgcctgcg caggtgttga tggagtctgg 3239941 atggatcgtg ggggataggt tgatacgatt tttaaggtta aattgcactt gtaaaaagtc 3240001 ttgttccttt ttcatatcaa atttatgcac atcaaatacc ttcataacga ttgctcactc 3240061 tcgacctaaa ttaatgtgag tctctcttct cgattctagt atttcaaaat gaggactatc 3240121 tgtatctatc tcgtacttat ttaatagatt gccttcttca tcccaattct tttcagaaat 3240181 tagtatggaa tgctcatact gttgctcact ttttttcctg ccattttcaa accaaattat 3240241 gcttataccg tgcaattgcc catatcggta ttctttttca ctttttttat tcccgttttc 3240301 ataaaattca catgttaaac catgggccag accattctta tatttagtaa aatagatgat 3240361 ttgaccattt ggatataatt cgtaagccag ccctgtaaac ggctggccat tttcgtcttc 3240421 aggattatct aaaatctcat cacttaccga agagaaccat aaatcctcaa agtccactcc 3240481 cttttctttt atactcttca tatcatattc attttccata ctttaaagcc tccggtatat 3240541 aatttgtatt ttgagttata tattcacaat gtggacatct aggcattggg acaccttctg 3240601 gcatcttttt atttattttc ctagcactta ctacatatac cattaaatct tttaaatccg 3240661 catcaggtct ttgaagtaac gcttcattta gagcattaac ttcggcatga gaacccgccc 3240721 ctgacgtctt tatataacct tctttaagtt ctgtaggcat atttacaatt ctatcatgaa 3240781 taagtggatg tagtacctta ggtggcttcc catctatatt gtttattcca aaataataat 3240841 tgcctgtttt tttgtccaat acaccagcta ccgcagggcc tctttgtttt ttagttagac 3240901 cagaagattt aattctacta agttcgttta gtacttctgc ccttagattt attcgatggt 3240961 gaagatcttc tttagacaat acaccatgct tatttcttaa atattgaagc ctagtttgtt 3241021 tttcttcagt agtcttagca atattgctaa taaggctttc attactcact ttattgacat 3241081 atggagcatt tttttggtac aaccgatcaa agtagtgtgc caatcctgct ccaccaataa 3241141 tagtaatagc ttccagcgcc ccttgcttcc gcttctcctc agacactttg tttccgaaca 3241201 tatcccggcc tgtgacagct tctgagaatc cgtttgacgc aacaaggccg tatgcgccca 3241261 tttctgtcat tttgagaatg tctaaggatt tgcctgtttt gtaggcgtct aatgcgtgtt 3241321 cagcagcgat agctgctttt ccggttttgt agatggcttt tccgcctttg aaggcccggc 3241381 ctgcccagcc gacgactggt atgaatccgg cagcggccat agctcctgct gtcacacgct 3241441 ccgcggtgga gagtttttct ccggtaaccg gatcaacgcc ttcggttgct cttttataat 3241501 cataatagcc agtgacttct ccagtaaagt tgcaaactcc atcccatgtt ttttcgtacc 3241561 acggtttgtt tgcttcttcc tcggcttttt cctggagccg tcttgcttct gcttgctggg 3241621 tttttgcatc gatataggtt gttccttgat tttctacttc aatgacgctt ttgtagactt 3241681 cattgctgtg gaaggctttt ttgtcatagt acatagggga tgcgctcttc ccattgctgg 3241741 tggcctgcat gagaacagaa tatttggtga gcactgcgtt gtccagagat tctaaatttt 3241801 gatattcagt ggtcagggat tcatcaagct tatcgacagc tgtgattgta tcacgtctga 3241861 ttttttgggc atcgcccatc ttatctgcat agtcgtcaag cgtgtacatg tcgagatcaa 3241921 taatatcgct gatgcctgac aaaatagaat cgatttcttc tttatgagcg gagacaatct 3241981 ctgaggcttt caggtctcca ttgggcagct catgatccaa aaaagaagtt tccacatatg 3242041 aatcattcag ttcttgatct ttaatatctc ctgaaatgcc gtttaaaaac gcaatttgag 3242101 cagagacaag cgtcagccag ctgtctacga tttctgcctg tccctgaaaa aaatctttaa 3242161 tattgtccgc gccatttcct ttaaaattat cgcctaaatc ggcaactccc tgaaacgctt 3242221 ttttcagcgt attcagctgc tcttcaagcg tctcatattg cttttttctg ctcttcgctt 3242281 cttcgattaa agattttgat tcaaatactt tactcatcgc actgcccttt ctgttctatt 3242341 ttaccgctat cgcctcgtcc tgctctttga gtgaatctac gttatccttt gtatcctcga 3242401 tatttttctg taccgctttt ttgtaatctc cgagcatggt tttgatgttc tcctcacgct 3242461 catggtattt tttcgtataa tcgaggctgt tttttccgtt ggatcctgcg gcgccgattg 3242521 atacgtcagc aagcgcatct ttgacagaat ctaatgtttt gatgactgtg tcgtacttca 3242581 gcttaatttc tgacataaaa aaagatcacc accattttag tttactaatt gtatttccga 3242641 cttcttccgc gaactcttct ccctttttaa gaagatctgc tgcaccattt gctatgaaca 3242701 attccgatgc atatttagct ttatcccatt caagatcaaa aattttcccg ttaatcgaag 3242761 ccatatactc gttatattta tcattcacaa tcttagatgc ttccgatttc gcctcttctc 3242821 ttcccttgtc gaaatcatcg gcttttgttc ccgtccaatg cttgcccaat tccggtttca 3242881 caatttcttt gatttcagtg attgcctctt cttgcagtgt gtctatgtcc ttttttgctt 3242941 ttttcagctt ttcgatcttg tcttccacgt ctgaaatttt tccgttgagc gaacttttga 3243001 tatccgctag catactttca taacccatct gaatcacctc ttaatactca aaaagtcgta 3243061 tggaggggct gatgaagata gacttttcca tactttattt ccatatatta tattttaaaa 3243121 tagccagaag gcggcttaaa tagggtaaat ggcttaattt aggcatataa cgctcttgaa 3243181 atgtaggtat ttgatcttgt ttttgttcgt tatacagcta ataaaagcgt tttataaaat 3243241 gaaatcacct aatgtcatag ttataaaggc acttgaaaga ggcagatgtt gttgatctgc 3243301 ctctttcggc gctgagctta ttgttcatgt ttatgttctt catctggtcg gccatgtctg 3243361 attttgtcat ttggcttcta ttattccccc cttctgaccc tttggatcaa aagcttgtat 3243421 tagctgcagt cccagttgta cagaacgttt gaaaagtctt ttttccttag atcttcaggt 3243481 gtgatgaaaa aattggcgat gccgacgtct ccccacattg aatcgatatc atcgtctgaa 3243541 tcaatttgta acagcatgat ggtgtgttct ttatatgcgt attcccgggg atcatgctgg 3243601 gtaaaagaag cgtatccgcc aattttatgg ccaaatccgt tttcagccag ttcattataa 3243661 atgtcttctt catcctcgcc gaactgacca aagaactcca ttgtttccat gcccgtatac 3243721 tgctcaaatt gaaaatctgt aggcagcacc cattccgaag atttcacagg ctcgactgcc 3243781 gcttctgata aaatcggaaa atcacattcg cctgtgccaa taaatgaaaa atcagaaaca 3243841 agctcgtcat cgttttctac gatattttca aaatagatca ctctgaaatt cttttgttca 3243901 catcgatcgt caaaattcaa tccatagacg tcatcatgaa cagaaatgta gaactgcagg 3243961 atacctgaag aagggtagcc gtcaagctgg ggaatgtgcg agaaattaat ctgcgccaga 3244021 agtttcatcg gctgtccatt ttcgtcagtc ggatatgttt catgcttggg gaaataggga 3244081 tcaccggcaa ttttgctgtc atatcgtcct gttttcccct ttctcacatt cagtttcacg 3244141 tattctttcg ctgatttctc cagcaagtcg cggtacggtc tcattttttc gggcagatga 3244201 ttcatcagat tctctccttt tccggcatct ccaaggtttt attttctggt tttcttctaa 3244261 tgtttttcaa acgaatgttt aaagaagccc tacttctgca taattttcca aacaatagtt 3244321 aaatagtagc aaatgtattc agcaccccgc aatagatgaa aaaaagactg gtgcgcaacc 3244381 agcctttctt tttcatctat tgaattgcac ctgacggaac aaccgccttc cgtccgacag 3244441 aataatactc cactcctgca gccaaagcct catccaatgt gtagcagttt ctgccgtcaa 3244501 atatgagcgg cgtttccatc aaatcctgat aagccgctaa cgggaattgt ttaatgtcag 3244561 cccagtcggt taaaatcatg acggcgtcag accctttgac agcttcctcg atcgtctctt 3244621 tatattcaac agcttgcggg agaacatgct ttgcatggct aactgcaatg ggatcgtagg 3244681 ctctgatacg ggcgtcgagc gcagcgagac ggtctgcaat aacaattgac ggcgcttctc 3244741 tcatatcgtc ggtattcggt ttaaatgaca ggcctaaaag ggcaatcgtt tttcccgtca 3244801 ccccaccgag cctgttcagc gctttatcaa ccagcatcgc ctgctgattg ttgttgactt 3244861 tgataacgga tttcagcagt tcaaaatcat gctcgacatt gccggcaatt tgcacgaggg 3244921 cgtttgtgtc ctttggaaaa caagagccgc cgtagcctat gcccgctttt aaaaactggc 3244981 tcccgatccg cttatcctgt cccatcccgt atgcgactgc ttcaatatcg gcgccgacct 3245041 tttcacatat attcgaaatt tcgtttataa aactgatctt agtggccaga aaagcatttg 3245101 aggcatattt gatcatctcg gcgcttctga tatccgtttg gtaaatcggg atttgaaacg 3245161 gacggaagag ctcctccagc gtatttgctg ttttctcatc ggccgtcccg atcacgatcc 3245221 tgtcaccatg aaaggtatca tagatcgccg acccctcacg caaaaattcc ggattggatg 3245281 cgaccgaaat actgacaggc tccgctagat gttcagtaat cagtccatta atcaaatcgt 3245341 ttgtcccaac gggcactgtg cttttcgtta ccacgactgt atctcgtttg acatgctttg 3245401 cgatgcgttt ggccgcatct gtaatttgct ccagattggc gtgcccgtcg cttttctgcg 3245461 gtgtgccgac cgctataaaa atgatgtctg cctgtgccaa gcctttctca tagctcgttt 3245521 caaagttcag ccgtccatca gctgtatttt ttctcatcag ctcttcaaga cctggttcaa 3245581 atatggggga aatgcccttt ctcatttcat caatcttgtg agcgtcaata tcaatgcagg 3245641 ttacatgatg tccaatctca gaaagagaaa cacctgtcac aagaccgaca tagcctgttc 3245701 cgatgactgt tatattcatt gtttccctcc aacagttaaa ttgctgcttt gcagcttccg 3245761 taatatcgta tgagaacatc ctatcatgaa tgcgaatgat ctcccgcata gcctgtcggg 3245821 tacagcctgt acagatttct gaaatgtgat tcaaccatac aatacactat tatatcgctc 3245881 tcaaaaagaa agtggtgaaa tgagaatcgg ctgttaaaaa aaaccaaaca attttcttct 3245941 tttgaccggc tgcggaggct gtctgaagat ggtctgattc cgcaggagaa gctctgcatt 3246001 ttccgtcagc atataaggaa gttccgagcc gaattctttc tctagaacat aaagagcctc 3246061 ttgagtgtga aaatttctcg ttttcacatt atgggcatct gaggctacga aatggatcaa 3246121 attggcttca accagccgga gagaaaatgc tttcagctgc ttgccgaaga tccccgcaag 3246181 acttcctgaa gtaatctgag atgctgctcc tttttccaca agatgataca gcaaggacgg 3246241 gttttcgcga atttccctgt tgcgttcagg atgggcgata accggaatat atcctttcag 3246301 ctgcaaatca taaaaaagct gctccgcata tcggggaacg tgatcaaacg gaaactcaat 3246361 caagatgtat tttgtatcat tcagcgaaag cagctgacgt ttggcaaggt cttgttccac 3246421 ctcgccgtag attctgattt cctgtcccgg aagcacatgt aaaggaatgt cttctttgat 3246481 taaacgtttg tttaactgat ctgctgcttc tctgactgcg gctggctcgt ttttatacac 3246541 accgttgtta tgatgaggtg tcgcaatgat cgtccggatt ccctgacgaa cagctgctct 3246601 tgccatttct atgctgtcgg ccgaatcacc tgccccgtca tccattgcgg gaagaatgtg 3246661 acagtgaata tcgatcatgt cctagccccc ttttttcgca aaaataaata acgggcacga 3246721 tgcacgttat ttatttttgc atgaaattgt ccttggttcc gtaatatccg tattcagagt 3246781 gcttcgaaag ctttttgccg ttcataatcg ccccaaggag cttgcttttg cacgttgcaa 3246841 gcgcctcttt cgcttttgcg gcttgttctt tttctgtttt cccgcttgaa ataaccagaa 3246901 cagaaccgtc tgccacgttg cctaaaatct gtgcatctgc tacggcaaga ataggcggcg 3246961 tatcaaaaat gaccatatca tatgccgcac acgcttcgta tgcaagctcc ttcatccact 3247021 tcgaggagag aagctcggcc gggtttggcg ggatcgggcc gctcgtcagc acgtcaagat 3247081 gtttttcatt cgatgcttgt acagcctgct ccatagagct tttctttaat aaaacagatg 3247141 ttaagccaac cgtattttca agaaaaaaag ccgtatgtac tgttggtttt cgcaaatcag 3247201 catcaatcag gagcactttt tttccctgtt gggcgaatac gacagccagg ttggcggccg 3247261 ttgttgattt tccttccccc ggacaagccg atgtaatcat gactgatttc atttgccggt 3247321 ccactgaagc aaattctata ttcgtgcgaa tcgtccgata ttgttcagag ttcaaggatt 3247381 tcggctctgt cattgcaatg acatttctct gcatccgcga gcctctgttt tttctaagcg 3247441 ccaaaatgtc cactccccgt tttttcagat tggaaaccct gtaaggtctt tgctgttttc 3247501 tgctcattcg caatggtgga aactgtccct aaaacaggta tgtccagcaa ggattcgagc 3247561 tgctcttccg atttgatcgt attatccaaa tgctcaagca ggaaggccag tccgatgctt 3247621 cccgccaatc cggccgcaaa cgcgatggca atgtttagta gcggctttgg cgatacaggg 3247681 gacgggtgtt ctgaaacctc ggcttttgac agaatgctga cattgtcaac attcataatg 3247741 gatgtgattt tgtcttgaaa aacagatgct atagtattgg caatatgagc cgctgtttcc 3247801 gcgttttcat ccctgactga tatgttgacc acttgggagt cctgttcgct ggatacggta 3247861 attttgtcat tcagttcttg ggatgtcatc gacaggccca tttctttaat gacttcatct 3247921 aagatggcag ggctcttaat gatgacattg tacgtattga ttaactgaag attggtttgg 3247981 acatcgttaa attggacttc ttttcgttca tttttcgatt ggttgaccag aatctgagtt 3248041 gaattttcat agatgggtgt aagtgcgaag aaactaatga gtccgccggc agcagtggca 3248101 gccgcggtta caatcataat caaaagtatg cgttttgtta acgttgataa tatctctttt 3248161 aagcttgtag attctcccat gatacctcca aatctcttat aacatccttt tccatctacg 3248221 attatacaac gttgaaaccg catttctcca gcttttcacg tgacataatt cgacattttt 3248281 ttacaatgcg ttatgttagt actttttatg taagcgctat atttactgtg ttgacagtgc 3248341 tgtctcattt tctcttattc gggcagtcac gttctctcgc ataaaaaaat cccgctaaag 3248401 gcgtgcggga tttttatgtt gcatatccat ttttaatatg agaaatcaaa ttttcaagca 3248461 tttccttcgt cgtcatctca gatgactgct caccaatttc atgtgcatgc atcaaaattt 3248521 tcagaaattc ttcttgattc aatttctttt cactcatctt ttttttcctt tcagcttcca 3248581 ttaagttgaa aacacgatta ttatatgatg ctggttatca atttgcaatc tctaatacat 3248641 cattcgacac atcctatttt ttatgtcctt ttttaggaaa aactttttaa ggccgatgtg 3248701 ttgcgatata atagagaaat tggatctttt tattacgtga ctcggttagg agcgataatc 3248761 atgcttcaga atatgatttc caaagacgat gtgctggcat ctgctgaaca gttaaaagaa 3248821 cttcttcctt acaatgagga aaatgttcag ctgatcaaaa aagcccttat tttatatcgg 3248881 caggattcag tctatcgttt acaagcagtg agtccgacgg aagttacggc ttacgtgcag 3248941 gatgttgtgc ctgtgcgggt cacattgaac ttgtttgtca tagtcaaaag cggctgttca 3249001 tgtccgtccg gaagaatctg ccgccatatg ctggctgtgt ttttatatgt atatgcaatg 3249061 ttcgagcgag tgggtacttt tacagagtat tggctggaga gggaaaagct tgaggaaagc 3249121 aaagagctcg tccgccgcca gtttcaggaa aaggtgctgc ctaatgaaga atcactttca 3249181 agctggcttg ctttttttga ttcagagttt tctctctggc aggcacgtac gccagaaggc 3249241 agccaaaaca tgcagggcct ctattacggc tacctgtccg cattaaaaaa acatgcgccg 3249301 aacaagccgg agctgaaaag cctgtatcag attcattccg cgattgcggt ttggcttcgc 3249361 atgttcacat tgattgaagc gggcaagcta aaccccgaac aagattttta ttccctcaat 3249421 ccgtacgttg aacagctgat ggatacaatc tacagctcta ttgataaatt aaaaacgtac 3249481 gcgctgtctt ttgcgcttga tccgtttttg gataaaacac cggatgttat ccggcatttg 3249541 ctgttgaaag aagaaatttt ccaatatgaa cgcatccgcg tcttcggtga aatttggagt 3249601 gcgctgctgt cgcggccaaa atgggtggca cgcgaacagg agatattgaa aaaagaagca 3249661 ggacggcgtt tttctcccga attgcaattc gggcgcctgc atttggaatt cctgcaaaaa 3249721 aatgatgacg ttatttttga ggaagcggat caattcccgc cggaagcgct cccttataca 3249781 ttccaatggc tgagtgaaat gactgccaag aaggactgga aacggcttaa aacatggtac 3249841 cagcaaattg aaccaattgc gatgggttat acgaagctgg ataagccgtt taaagagatt 3249901 cgcgatgtga tcggcgagct gttccttctg ttgaatgcct atgtgcagca aaccaatgat 3249961 caagcgctgt ttgagcgctt tgccgcgggc tgtctgccgt atacgttcac agaatacagc 3250021 catcatttat atgaaaaaaa acgctatgcc gagtggattg aaattcatag ccttgtcggc 3250081 ttttccatca atgaaatgga taaaatgatg ctcaaggaaa ttgcagcgag cgaccctgag 3250141 gcgcttatac cggcttacca tagagaagtg gcttttttca ttgatcagaa gaaccgtagc 3250201 tcgtacaagg aagccgcccg gtatttgaaa aaattgcgca ccctgtacaa aaaagcgaaa 3250261 aagcagaagg tgtgggagcg gtatattcag ctgctgagct cgcattacaa gcgcctgcgt 3250321 gcgcttcaag aagaactgca gaaaggaaag ttgattgatg gcgagtctta aagaaattct 3250381 catccacgtc gaacaaatgg aagatgggtc atttacgctc tcagcctttg atgagaatga 3250441 gcagcctctt ccctacagcc atatgaaaaa gcatttgttc caatggcatg aatcctcatt 3250501 ttacggaacc tttctagagg atgtcagctt catcgggacg actgctgtcc ttctatctcc 3250561 atggatgact gtagagcttc tcggcaaaaa ctcgttcaac tcattcagct ccgtgcagct 3250621 tacagaagaa acggagccgc tgatcgaggc ggcatcgacc atctatgaat ttatcgcgga 3250681 cggcgatttt atgcctgact atgacgcatg gacaaacggt gtttttcgct ggaaggaccg 3250741 cgataatata ctggaaggct ttactgcgga atggttttcc gctgccgtac aggattacat 3250801 ccagtacgac gatgacctgc gggagaaatg ggaacatatc aaggaaaaat cgcctgcggt 3250861 tacgacattc cgtggccatt ttcttgatga agaggatttt ctggaaggca ttggctggat 3250921 tgacgatcaa tctccattta ctgtcggctt gcgcttaaat gaaccggact ttgacggaga 3250981 cgaatggaag atcgagatgt ttttacgcga taaaaagagc ggtgctgtag aattctttga 3251041 cggactgaag agcctcaaaa aatcgtggca ggcgtacagc gataaaatcg cgcgtgagca 3251101 ggaccgcttt cacagaacgg ttccgtggct gtcgtttgat tccgggacaa cgctgatctc 3251161 ggaggaagaa gcctggatct tcctgtcaga agcaagtgag acgcttgtcg atatgggggt 3251221 agaaatcctc ctgccgtcct ggtggcagat tgtcagagac agcaacatga tgctgaaagc 3251281 aaaggtgtct tcctccccgc gcggcgagtc atttgtcggc atgaatgcac tgcttgattt 3251341 caactggcgg tttgcgacaa atggaattga actgactgag gctgaattta atgagcttgt 3251401 cgccagcaac aggcgccttg ttaatatccg cgggcaatgg gttaaaatcg atccgcagtt 3251461 tatcaaacag atgaaacgcc tgatggaaaa agcagaatca gagggactcc acatgtctga 3251521 tattctggcg cgggagctaa tggatcagca ggatggcgga cttgaggatt cggacctgat 3251581 tgatacatct gcttttgccg gcattcagtt tgatctgtct aaacagctca ggtcactgat 3251641 tcgaaagctc actgccgcgg aaaacctgcc ggagcacaaa gtcagtcctt ctttcaaagg 3251701 aacgctccgc ccttatcaga aatacggcat gaactggctg ctgtttctgc gggaaagcgg 3251761 ttttggcgcc tgtctggctg acgatatggg gcttgggaaa acgattcaaa tgatcgccta 3251821 tttccttcac gtgaaggaaa gcggccgaca aaaaacgcct catttgatta ttgcgccgac 3251881 atccgtactt ggcaactggc agcgggagct tcaaaccttt gcccctgatc tgtctgtcgc 3251941 gctccattat gggccgcgcc ggccaaaggg tgatgatttc gccgcgcatt atgaaaacgc 3252001 agacgtggtg ctcacttcat acggtctgtc acatgccgat actgaagagc tttcttctgt 3252061 gacatggaac acgatctgcc ttgatgaagc gcaaaatatt aaaaacgcgc atacgaagca 3252121 atcacgcgca atcaggaagc tgaaggggct tcaccatatc gcgctgagcg gcacgccgat 3252181 ggaaaaccga ctgactgagc tgtggtctat ttttgacttc atgaataaag gctacctcgg 3252241 cagtttgacc ggcttccata aacgctatgt gctgccgatc gaaaaagacc gggacgaaaa 3252301 gagaatcgga cagcttcagc aattaatccg gccattcctt ctccgccgga cgaaacggga 3252361 tgaagaggtc gcgcttaatc ttcctgagaa gctggaagaa aaagaattta tccctctgtc 3252421 agccgagcag gcatcccttt atgagcagct cgtcaaagac acttttgacc atatgacatc 3252481 cctgaccggc atgcagcgaa aagcgctgat cctcagcatg cttggacggc tcaagcaaat 3252541 atgcgatcat cccgcgcttt atttaaagga agagcaaacc gagctgctgg ccggcagatc 3252601 agtcaagctc gaaaaattgc tggaactgat gacagcgatc cgcgcccaaa acgaaagctg 3252661 cctgattttc acgcaataca ttcagatggg gaacatgatg aagcggctgc ttgaaaaaac 3252721 gttcggggaa cctgtgcaat ttttaaatgg gagtctctcc aagcaagagc gggatacact 3252781 cgttgagaaa tttcaaagga aagaatatcc gacactgatt ctttcactca aagctggagg 3252841 caccggactt aatttgaccg ccgccaatca cgtcatccat tatgacagat ggtggaaccc 3252901 ggcggttgaa aatcaagcga ctgaccgtgc ataccgcata ggccaggagc gctttgtcca 3252961 cgttcataaa atgattacga caggaacaat cgaagaaaaa attgatgtca tgcttgaatc 3253021 caagcaaacc ctgaacgatc aaattatcca aagtgaaaac tggattaccg agctttccac 3253081 acaggagctc gaagaattgt ttacattaag cgctacagcg caataatcat gactaaaaaa 3253141 gctggctcta aaagagccag cttttttccg ttcatagccg tcacgccgaa tttccaaaaa 3253201 atccgttacg ccggttatca acagggtgcg cttttgtggc agcacatata cttacaacaa 3253261 atgtttcatc atatgtgcga caccgtgttc gtcattggtt aaggtgacag catcggctat 3253321 cgatttgatg tcttcccggg cattgcccat cgctacacct tttcccgcag cctccagcat 3253381 cgatttgtca tttaaactgt cacctacagc agcagtttcc tcgagcggaa tattcagctg 3253441 ttttgcaagc ctcttcagcg cctgcccctt ggaagctttg cgggaagaaa gctcaaagtt 3253501 gtgctcagcc gaactgacaa gcgtcaaatc ttcggcatgc tcatatcttt tccagcctgc 3253561 ctcaagcttt tctttgaaga aagaaaagcc gagaatattg taaaaatcga ttggctcatc 3253621 ggcttcaaac agctcttgaa aggagttaat gtaagcaaag cccgattggc tgtattgcac 3253681 ctcggccgcc tgcttaagga cagaaagatc cgcttccgga tttgcgcttc tgaatctgtc 3253741 gagctcaaca tcaagaagtt ctctgccgtt ttgcggcgta taaatcgctg aacctgtgaa 3253801 tacctcataa taatagtttt ccgactcaag ccatgagaga atgtcatacg cccgtttctt 3253861 atcaatcgtt tcgtgatgat aaagcctgcc ctcgggatcg tgaatgacgg cgccgtttgc 3253921 actgatgacc catgttttga tccccagcgg ttcaaagatt gacatgacgt caaaatgagc 3253981 gcgcccagtt gacaccacca cttcaatgcc gtcccgctgc gcctgccgca gtgcgttttc 3254041 attttccaag cttacctgat gcttgctgtt gagtaaggtt ccatctaagt caatcgcaat 3254101 taatttcacg tttgtcagtc ctttccttca tcctgctctg tcacgagaag ctcaacgccg 3254161 tttcggtcaa gcaagtcaca aaatgcctga ttcggcagcc tgtctgtaat caagaggtcg 3254221 atttcattca gctccgcata ctgataaaaa ctggtgctgc ccagcttaga atggtctgca 3254281 agcgcaatta cctgctttgc ctgctgtatc attttccgct tcaccatgcc atcctcttca 3254341 tgcgcaattg taatgccatg ttcggaaatg ccgaccacac caatcagcgc tttatcaaca 3254401 tggtagcttg agagcttttc aatcacagag gacccgtaca gaaagcggtg ctccttttcc 3254461 agcttgcctc ccagcagata aatttcaatt ccctctttat cggacagcac atccgcaaga 3254521 ttaatcgaat tggtgattac ggtacaatca accgcattca aatgctttgc acatgcctga 3254581 acagttgtag aggcgtctaa aatcacccgg tctccatcat gaataagcga tgctgcaagc 3254641 ctgccgatct tatttttttc ctcagacact gttttcaggc ggccggaata gctttgaatt 3254701 ttctgatgca cagtcggtaa aatggcgccg cctcttgtgc ggatgatggc attctgttcc 3254761 tcaagtttca caagatctcg tcgcgctgta tcccttgaca cttgcaggag cgtacagatc 3254821 tgctccgttg taattcggtt atgctgtttt aaaaaatcca aaatcgctac taatctttct 3254881 tcttggtaca cgccctcatt ccttttctca gcaatcattt ataagtaatt ataagttttt 3254941 atttgatttt attcaacatt aataagtgat tttaagtaaa aatgcgtcga gagaaccaat 3255001 ttttcctaag taggcaaaaa gaaagaacca gtctggtcga ctggtcaatt ttgaggggat 3255061 gatgcgaaga tccggataat agtgaatgga tagataacgg gaggagcagg ggtgtcaatc 3255121 agcagctttt tcccggggtt tagggtccat aaaacgaaca gtgtcagcca acacttctgt 3255181 tacatacacg ttaacgcctt cctcgttttc atagcttctt gtctgaatcc gtccgcttac 3255241 gccgacgaga gaaccttttt ggcaatacaa cgccgtgttt tcagctgttt ttctccaaag 3255301 tgtgcaattg acgtaatcag cttcgatttc acctgaagca ttcttgaagc tgcggttcac 3255361 cgcgagcgta acatgtgcaa ctgccgcacc ggcggaagtg tagcgaagat caggatcttt 3255421 tgtaagacgt ccgacaagca tgacctgatt gaacatgcga ttcctcctct ccttgcggtt 3255481 gtatgtattg taaatgatgc aacaagaaaa gaaaaacgct taaaaatggc tttcagcctc 3255541 tgtttttatc tttcgttttc atttttcctt cagctaaaaa catcttttgc ttttttcctt 3255601 tgaagaaata tgtacttttt aaaaaacgga aaaagatttg ctttgtcagc cagttttgcg 3255661 tattcatgcg cacataggaa gagccatccc acgcaaacca ctgaaagctc aatttttttt 3255721 ccggcattga cagcttgatt ttatactgct ccatgccatc ttgtgtttcg tataaaaaac 3255781 ttattcttcc ttttttgttc agatgaacct caaacacttc tttacggctt aacatatatg 3255841 ttacttcctt ttgaatcaaa tgactttcag aaggaacgcc gtcaatataa atttctttta 3255901 aacgaaattg attcatacca catctctccg taatccatag tcagttacag tataatgaaa 3255961 aaatagaaat tattaaatgt ttcgctcata caaaattctt tagccccaac attgcaggat 3256021 tttttcctcg aaaacgttta tgttataatg gaaggcaaga aaactttgga agtaatcggg 3256081 gtgagaagaa atgaaaacct ttaaactggt tgacctgaat gtggaacgag tggacaagga 3256141 agaacaatca attgaacagt ttccccttat tgacggactg attataaata aagaagacgg 3256201 tgaaaatcac tggctgattg aggcgcttgt acagaaagaa catctgtctt tttttgaaca 3256261 gcttcaaaac agccaatctg aagccaaagt atttgtaacg atcacgaaaa aaagcaatcg 3256321 ccccgcccag ctgacagcag cagtgaaaaa tatcgtcaag ctggaagaaa gcattcaggt 3256381 tttactctac ggacaaatgg tcacaagaaa acagcagggc actgaaacca ttctcgagtc 3256441 ccttgtaaaa gagggctata caggaacaaa actcattgag gcatttaagc aaaaattata 3256501 aatatgaggg ggcatgttcc ccaaaacaga ctcagaaccg aagagcatca caatagacat 3256561 ttagaataga tatgttctgc atgaaaaaag ctgccgtttt gaacggcagc ttttctcttc 3256621 gtgctttcac tcttgcatat ttaatttgta tggccaaaag aatcaaccaa ttcccctttc 3256681 acaacgaggc gcccttcggt tttgaccgcc ttgtcacatg tgattaacgt aatctccttt 3256741 ttgtttgtct cctcaactac atctgcatcc atttccgata tgatgtcttt cgatgttaca 3256801 gaatagatat aatccttttt aaaatccgtg atgacaattt gggcacctgt ttttatgttt 3256861 tccagaggtc cgaacagaag attcttttgc ttcaaatgat ggcccgccaa cggataattt 3256921 ccctcaccca ttttttgatc ccggcgcatt gttgccgccc ctatcaaaag attttcattg 3256981 gttgtgcctt ttacgatcgg aagctccaga tcgacacttt taattgttat ccgccgcctt 3257041 gattgtgaag taaaaataag tatatttcac gtgctttcga cgttctccac ttgactggaa 3257101 tgctttaatg gcgatcccgg catctgtagc ttcaggcttt ccttcagagg aatcagaaat 3257161 ctcaaactct attttctcag tgttcagcac ataaccggct ggcgctttcg tttcaacaaa 3257221 agcgtattgt cccggtgcaa ggcctgaagc tgtgacttga tgatgccgga tatgactggt 3257281 ttcgaagtct gtatgaaaat tcgcgaacga ttcagcatgg ttgatcttcc ggttctgatc 3257341 attacagctg ccattatcgg ccatgacaaa tacaaggctt ttcatgccgg agcgaatgac 3257401 attttgcaaa aaccctatca ttactctgaa tttatggcgc gtattcaaaa cctgataatg 3257461 atgaaacata cagcaaatca agccacaaga atggaaatgg cgtttctcca gtcgcaaatc 3257521 aagcctcatt ttctttataa tgtattaaac acgattattt ctctcactca tttggatatt 3257581 gaaaaggccc gggaggtaac agaggaattt accaactatt taagaatgag ttttgacttt 3257641 caaaatacat cagccatcag ttccttcaga catgagcttt cgattatcaa ttcctatctt 3257701 tctatagaaa agacgcgatt cagtaatcgg cttgaggttc ttttcgatat agatgaagac 3257761 attgacttta tccttccgcc tttaatgatt cagcccttgg tggaaaatgc cgttcttcac 3257821 ggtgtcagca agaaaagagg cggaggatgg atcaaactga cagctaaaaa acaaagcaaa 3257881 aatgagtatc acatcaaagt agaggataac ggtcccggga taactccgga aaaacaaata 3257941 gatctcttat caacggattt tgatcgcagc gtcggattga aaaatatcaa tcagcggctg 3258001 aaacattttt gcggaagcga gttgatgatc agcagcactc cggatgcagg cacctctgtc 3258061 tcaatgctca ttcatctcgc tgaaacaaca ggaagcccta aagaactgaa ggacacagaa 3258121 cgaacctaaa cgaaaattga gataaaaaaa gacgccgttt ctaacggcat cttttttatt 3258181 ccggcgactt tgcttgctgc ttcagcaggt ctctgatttc tttcagcagc tcctcctgcg 3258241 catccaccgc ttcctccgca gcctcttctt ctgcttcttt tttgcgcctt aacccattca 3258301 aagtccgaat gacgataaaa atggagaacg atataattaa gaagttcaca atcgtctgta 3258361 taaagctgcc atatttcact acagcatcgc caaacgtaaa cgacaggcct gaaaagtcaa 3258421 gccctcccag cagcaaaccg accaaaggca taatgatatc atttactaga gatgtgacga 3258481 tctttccgaa agcgccgcct atcacaacac caatcgcaag gtctacgata ttcccccgca 3258541 tggcaaaggc tttaaattca ttccacatac aatcacctgc ttttctatat ttgtaaagaa 3258601 aaaaagacaa atgtgccgct ggccatctgc cttttttcaa ttattctccg agggcaaaag 3258661 tcagttctac ttcgcaaacg acttcgccat caactgtggc aacgcctttt ccgcgcccga 3258721 ttgtgccgcg ggcacgaatg atttcaacct caaggtgaag ctggtcacca ggcttgactt 3258781 gttttttaaa gcggcagtta tcaatgcctg caaaaaaagc cagtctgccg cggttttctt 3258841 ctttaatcaa catcgcaaca gctccgactt gagcgagtgc ttctacgatt aatacgccgg 3258901 gcataaccgg gtactgagga aaatgtccgt taaagaactc ttcattagcg gttacatttt 3258961 tatagccttt tgcccgtttg ccctcttcaa cttccgtaat ccgatccaca agcaaaaacg 3259021 gataacggtg aggaataatt tctttaattt gctgagtatc aagcattgtc ttgacatctc 3259081 cttcatctgc attagtatgt atagcaatca tcaaagatcc aatctgtaca tttgaaaagt 3259141 atattatgaa ttaatctctt tttcaaccgc gctaaaatgt aaccaactgt caatgagagc 3259201 cgtcaaaagt tatgatatga taattataga ttttaccaat agcaaagagg taggaaaatg 3259261 atttcgaagt ttattgaaaa aagaatgcta aacatgttag acgagtggta ttccgcaatg 3259321 agcaaacgca aaatgaatca cgtttgcaca ctgaaagaga aaattgatca gcaccttcca 3259381 aagatcaaaa agaacacaaa actttggatg cgttatcaat tgtttcaggc ccgccatcag 3259441 ctgctttttg aaaaccagaa cggactcgat tcattgttcg atggcctata tggcctggaa 3259501 gacaaaatgg atgatgaatt gaaatattat ctgtattttt tctctgggtt atatgagatg 3259561 gtaaaaacag ctccgaaaca tgcagtacat cattttaaaa aagctgaaca gtacctggcc 3259621 gccattcaca atacgtttga agccgctgat ttatattatc aaaccgccgg cgcctattac 3259681 ttgatgaaat caccgccgct ttccgtccaa tacgtcaaaa aagcattaca catctatttg 3259741 caccaattcg gctatatcaa aaaggtaatc acctgtaaac ttttgctcgc cgtgaattat 3259801 attgatcaag aacgctatga aaaagctgaa cagcttttca aagaaatcat taagaaaacc 3259861 cagcaactac atgacgaaaa cctgctatgc cacgcttatt ataaccttgg ctttttaaaa 3259921 gcgaccgaga aaaaagacca ggaagcgctt ctttacttta gaaaagtatt aaagaatcaa 3259981 gaatttgaaa tgaattcacc agtctcatat cttcattgtg tgtacgagtc tgtcagagcg 3260041 ctttttaaaa cagggaacat cacagaagct aaagccgtcc ttcaaaaagg aaaagaatta 3260101 tctgaaaagg tagacattca aaccatttat ttaaaattaa aaacgcttga agccctctac 3260161 acatcagccg aagaccctta tgagcagctg ctcgaatatg tgcttgaatt agaaaaaatc 3260221 gaggcgtggg tggatttaga agtgctgtta gaagatatta cggaatacta caaaaaaaag 3260281 gacgatttcg aaaaagccgc tttttttatc atgcgcggct gattgaaaaa cgcccatttt 3260341 cttattatct gactgaattg attaaaccga gcatttgatc tcccattgtg atcgttctgc 3260401 tgttcagctg atatgaacgc tgggacgtga tcaaatctgt catttgttct gaaatatcga 3260461 cattggacat ctcaagtgag ccctgctgca tgccgatgtt ttgtctatta gcgccgttca 3260521 gctcttcaaa agctgccgca ttatcaatag agaaaaggtt attcccttcg gatttcagct 3260581 cttgagggtt attcacttgg acaacgccaa gattaaaccg ctgaaccgcg tttccgtcag 3260641 atgcggttaa ggtgccgttc ttattaatgg tgatattctt cattgagctg tcgatgttca 3260701 ctgtattgcc gttctcatca agtacgggat acccatttcc agtgacgagc tgcagctggt 3260761 tggcattcgc agcggacggc gttacataca gcgccccgtc cctcgtatac tggcggtttc 3260821 catttacatt tacctgaaga tactggtatg gagacgtaaa tgcgatatcc agatcgcgat 3260881 cggtcttctg aatgcttcct tgatcagaga ctaggcgtga actcatcatc gctccgacgc 3260941 caaggcgcaa gccgggcggc gtttttcggg cttttgccac ttcctcgttt ttttcatcaa 3261001 cctgatcgaa ttgctgtctg acaagctcag aaaaattcgt atcttttgcc ttatagccgg 3261061 ttgtgttgct gtttgaaagg ttgctgctga ttgtgtcaat ctgctgctgc agctggttta 3261121 aggttgttga tgccgttagc attgacctga gcatagttga tgtcccccgt ttttttcttc 3261181 cgttttctta aatttttcca atttcatttg ctgctttatc catactttta tcgtaagcct 3261241 gaataacctt ctgattcgcc tcaaacgatc tgtacgcttc agtcatttct gtataggcgc 3261301 ttgtcacatc cacgtttgaa agctctgaga cgccttgttt taatgaatag gctacctgat 3261361 tatttccggc tgcgcttggc agatcattac cgtccgccgt gctgtacaaa tcatttccgt 3261421 cccgtttgag attgcggaca tcttccgcca ttctgacatc aatctggccg gctgtgcgtc 3261481 cgttcgttgt cacagtaccg ttttcagaca cagtgaaatt ctcattatca acagtgattg 3261541 gctggcgatc cgtcgataaa atagggcgtc cgttgatcgt cagctgattg ttctcattta 3261601 gtgaaaatgt gctgcttttt gaataacgga ttccatccgc tgtttgaacc ggataaaaaa 3261661 gagcagcttt ttcattggtt tccgcactca tcggaacttg attttcgatc aatgcaatgt 3261721 ctgtaggctg gtctgtggac ttcaggcttc cctgtgtaaa gagaggcttg agctcctgca 3261781 tatatactcc ggtattcacg gaaccgattt ccgtccttga tgtcccggcc ggagattttg 3261841 attctattct gctgagcagc atctcaggga acgcgcgcat agagccttga tcagctttat 3261901 atcctgatgt atttgcgtta gcaatattat ttgaaagcat ttccgttctt cgctgctggg 3261961 caatcattgc ggatgttgct gtatataatc cttttaacaa atttcccacc tctaaaaatg 3262021 gcattttttc cagttgtcat ataggaacgt tcgttctata ataaaaactc agtattttat 3262081 cctattatcg tcatttaaca tcttttcgtg aaggcttttt cataaaaaaa cctcattctt 3262141 tttcagaatg aggtttgtga aatcagctta gtttgcgttt aggaagcttg tccatattat 3262201 caagcatgac acctgtgccg atggctacgc aatccatagg attttcagca acgaggaccg 3262261 gtaccttcag ctcttcagca agcagctggt caaggccgtt taagagcgcg cctccgccgg 3262321 taataataac gccgcggtca ataatatcag cagaaagttc aggcggtgtt ctttcgagca 3262381 cttgttttgc agcctgaaca ataacagcga cagattcacg aagggcttct tcaacttctt 3262441 tactgtttac tgtaattgtt cttggaagac cggaaaccat gtcccgtccg cgaatggaaa 3262501 tttcctcgtg acgtgcgtct gggaaaacag ttgcgacttt aatcttaata tcctccgcag 3262561 tacgttcgcc gatcagcagc ttgtactcgc gtttgatata atttaagatt tccatgtcaa 3262621 acttgtcccc agccatttta atagaagagg aggtgacaat atcgcccatt gaaataaccg 3262681 cgatatccgt cgtcccgcct ccgatgtcta caaccatgtt accgcttggc tggaatattt 3262741 ccatacccgc gccgatagcg gcaactttag gttcttcttc aaggtacaca tgtttcccgc 3262801 cgcttttttc tgcagcttct ttaattgctt tttgctcaac ggatgtaata ttcgtcgggc 3262861 agcaaatgag catgcgcggc tttgagaaca ggccttttac attcagcttg ttaataaaat 3262921 gtttcagcat tgcttctgtt acttcaaagt cagcaataac tccgtctttc agcgggcgaa 3262981 tcgcaacaat attcccaggt gtacgtccaa ccattcgtct tgcctcttcg ccaaccgcca 3263041 gcactttgcc gctgttttta tcaagtgcaa caacggaagg ttcattcaga acaattcctt 3263101 tacctttaac atggatcagt acatttgcag taccgaggtc aataccaata tcccttgcaa 3263161 acatctattt atatcctcct tgaaaatctg tttcacagta aatatccaca ttgtgcccta 3263221 attatatata ttatcataaa atatagaaaa aaagttggaa gcacaataag ttctttacaa 3263281 atttttgcgg atgttttatg aacgatttca agaaggcaat gccaggtgat tacgattgct 3263341 gaacaggctc tccttcgaga atttcatctt ttttatattt gagctttgtc gcttctcctc 3263401 ctcttaaatg cctgatggat ttatgataat cgagtatttc tttcacttcg tttgccaagt 3263461 cggggttaat ttcaggcaga cgctctgtta aatccttgtg tactgtactt ttggaaacac 3263521 caaattcctt cgcaatgaca cgaacggttt tctttgtctc cacgatgtac ttccctatct 3263581 tgattgttcg ctctttgatg taatcgtgca caccactcga cctccctaaa atggatgtga 3263641 gaagtgtgaa atgagatccg tattctgtaa agagtcgttc attatgccgc ttcttcgttg 3263701 tatggtttta aaagtaagtt tgtgaaatat gcccacgatc cctcacctca aacactctct 3263761 ttgttaggtt tgtaacagtg tattagcatt cttttgggaa tatgctaaaa actcaataag 3263821 gacaaggggt gaaacgaact ttttcagatt cagcaaacta tttcgcgtca ctaaattttc 3263881 atctttacaa ctattgatcg ctcctgtaaa atgaaataag caattagtta cttaggtaag 3263941 ttttttagaa ggagaccgac atgtcctacg tcaacagaca cctcattcat caaatcaacc 3264001 aaagcgcccg cctgattgcc aagaaagcca atgaacagct agagccattc ggcctttatt 3264061 catctcaatg gtcagtttta tattgtttgc gtacgatcgg accaatgact caaaaagaga 3264121 tttggtccta tttaaatgtg gaagcgccga ctgtgactcg gacgatcaaa cgcctggagg 3264181 agaacggctg ggttcagaga cggcaaggtg aagacaaacg ggaaaaactt gttgtcctca 3264241 caaaagaagc cgagaaaaaa tacgaagaaa tcaatgtgaa aatgttgaaa ttcgaggaag 3264301 agctgcttgc agatttccgg gatgaagata aagaagcttt ttctcattta ttccgcatgt 3264361 ttttacaaca atgaaaataa ggaagtgaca tacatttgaa aaaagcggat gcgatatgga 3264421 ccaaggattt tattatggtc ctgcttgtca atttatttgt gtttgtgttc ttttatacat 3264481 ttttaactgt attgccgatc tatacactgc aagagcttgg cggcacagaa tcacaaggcg 3264541 ggcttttaat cagcctgttc cttctgtctg cgatcattac acggcctttc tccggagcca 3264601 tcgttgagcg tttcgggaag aaaagaatgg cgattgtatc aatggcgctc ttcgccctat 3264661 catcttttct gtatatgccg attcataact tttccctgct gctcggattg cggttcttcc 3264721 aagggatttg gttcagcatt ttaacgactg ttacaggtgc aattgccgct gatattattc 3264781 cagccaaacg gcgcggtgaa gggcttggat actttgccat gtctatgaac ctcgctatgg 3264841 cgatcgggcc tttccttggc ctgaatttga tgagagtggt aagctttcct gtattcttta 3264901 cagcctttgc gctgtttatg gttgcgggct tacttgtttc gttcttgata aaagtgccgc 3264961 aaagtaagga cagcggcacg actgtattcc gttttgcgtt ctcggatatg tttgaaaagg 3265021 gcgcactcaa aattgcgacg gtcggtttgt ttatttcttt ctgttattca acagtcacat 3265081 catatctgtc tgtattcgcc aaatcagttg acctttcgga tatcagcgga tatttctttg 3265141 tttgttttgc ggtgacaatg atgattgcac gcccgttcac agggaaattg ttcgacaaag 3265201 tcggaccggg cattgtcatt tatccatcaa tcctgatttt ctctgtcgga ctctgcatgc 3265261 tgtccttcac acatagcggc ttaatgcttc tgctttcagg ggcggttatc ggtcttggct 3265321 acggatcaat cgttccttgc atgcaaacat tggcgattca gaaatctccg gctcaccgct 3265381 ccggttttgc gacggcaacg ttctttacct tctttgacag cggaattgct gtaggatcgt 3265441 atgtattcgg attgtttgta gcatctgccg gcttctctgc catttattta acagcggggc 3265501 tgttcgtttt aattgctctg cttctctaca cgtggagcca gaaaaaacct gcagaggctg 3265561 aaggaaaagt gtctattgca gaataacttg tcagactgcc gggaaatccc ggcagtcttt 3265621 tttccattaa aacacggcgc cctctcggtt gaacgagaga acgccgctta tagcaattat 3265681 tcaatgacag gccgcgcagg tgaatcagga tctaacgaaa aatcatagga cgcttcatca 3265741 cgaaacatcg gatcggcata tatggattgt tgatcgtttt ttgttgcttt tcgatacgaa 3265801 gaaaatgaat catattcttt ctttttccac atccatatgc cgtcttgatc cgcttccttg 3265861 tggtacacgt tatgattgac cgtattacct tcgttttctg taaagtcgtt tccgataaat 3265921 aatctggaat caccggccgt caatatattc ttttcaattg tgttgttttt cgtatcgtac 3265981 tgcagcagca gctgtccgcc gtacagtccc tttgtgtcat tccggtacat aatattgcgg 3266041 gcaatcagag aattgctggt gccgccccgc tttttgtcat atcctccgat tgaaataccg 3266101 gtgtacgcat tgttgtacac tttgttgtct gtgatctgaa tggcatttgc atactttcct 3266161 ttgtgttcag acgttgcttc aatcccaata tcgttatcgt aaactgtgtt gttcttaatt 3266221 tcgatatcgt gtcctccatc gacataaatc ccgcccgctg agtattcatc tccataagca 3266281 ggattgccgt aagtcgagtt ttgataaact gtattgtttt ctacgactcc gtttcgcacg 3266341 taatcgtttt tatccgcggt tccctcataa ccaattagat caatcccgat gttattattg 3266401 ttgcggacca cattgcctgc aactgtgaag ccgtcgatat taccgttcag cacaactgct 3266461 tcactcgctc caagcgtcag tttctcaact gtattgtcct cgattcggat gtctttcatg 3266521 ctgccagtcc cataaactgc gattccgtga gcatttcctt catccgctgt tgtcttaatc 3266581 ccccggatgt gattatcctt aatggcgata tgactgctgg accctgatac ataaatccct 3266641 atagcagttg cttcctcaga tgaaacagaa agatcttgaa ttgttaaacc gctgatggca 3266701 atgtcatgtt tatcgtgaat acgaataagc ggtgtttcat attcagcgtt cgcaacggat 3266761 tcaccgctaa tcacgacgtt ttcattttca tagtttcgga atgtgatagg ctttccgtcc 3266821 gtaccgctgt gctttacatc aagggtctca tgatacgtgc cctcccgaat catgacagtt 3266881 gtgccggcag cagccttctc agatgcgtgt gccaatgtac gaaacggctt ttcttttgtt 3266941 ccttcatttt gatcactgcc atttggcgaa acatacagat aatccccaga tccttcctca 3267001 ttcgcttttg tcttatcata aacgaaagcg aggatgacag acgttaaaac acccgccaaa 3267061 agaataaaat accattttct cattttcgat tcccatttcg ttttagaata gatttctaaa 3267121 accattataa atgttctatt tatggaaaac catttcaaaa atatgaaaat ataccgtcta 3267181 aatagatctt attcagcctg gcggacctgc gcatgttcaa ctgtttcaat tgccaatgat 3267241 gcaggcgggt gaacacgcat cagaacaatg tagaaaagaa aggaaatcag cacacctaca 3267301 aaccaagaaa tatcgtataa gctcttcaat acaggaacat acatgccaat cagcgaaatc 3267361 agcgctccta acattgtggc tgcaaacgca cggtaattgt agcccttcca atacacatac 3267421 cgtcctgttt cggaatacag gtcatctacc gagagctcac gtttgcgaat gataaaatag 3267481 tcggccatca tcacgcctgc caccggtcca agcatgccgc ctattaagcc aagaaacgca 3267541 tacacgcttg tcgcgctctc catcagcttc cacggaaccg taaataaagc gagcaacgct 3267601 gtgataaagc tgccacgttt gaaattgata tatttcggca gggcattcgc tatatcataa 3267661 gcgggtgata cgatattcgc cgcgacattt acagagatcg tggcgatgca gagtgtgatc 3267721 acggacaaga cgatgacata agggttatca aaccgcgcca aaatatcgac aacatcccaa 3267781 atcggctctc cgaacgcgac ctgcgagccg gaggtcaccg taatacttgc gaatgcgaac 3267841 agcgcaaacg ttcccggcaa accgtaaaat tgtcctttga tttgctcttt ttgtgtttca 3267901 gcaaaccgtg taaaatcagg tatatttaag atcaatgtcg cccagatgcc gatgatgcca 3267961 gtaactccgg cagcaaacgg ccagaatgtt tctgaaaacg tatgaaactt tcctggttga 3268021 gagtatatcg ggcccaatcc tccagcaata tcaacggccc accataccat gccgccaaat 3268081 accagataca ctaaaggccc tgcccacacc tcaaaacgtt taatcgactc catgccgtga 3268141 tgcaatacga gtaaatgaat ggcccaaaag aatacaaagg aaagcaaacc ggacaagtga 3268201 atgccgagaa tgttccactc gccgccaatt tctccccaac ctggccacat attcaaaagc 3268261 aaaatgttca gtgccgtgct acccgcaaag gtctggatgc caagccacat gatagctgta 3268321 aacgccctta gaagcgcggg gatattcgcg ccgtatatcc cgtaagaagc ccgaatgatc 3268381 actggaaacg gcagcccgta ttttgtcccc gcatggccgt ttaaggcaag agcgccaaat 3268441 aggataagtg atgccgtaat aatgatcgcc agcacctgcc aaggcgaaag gccgatcgca 3268501 attaatcctc ccacggtcgc gtaggtcggt atgttatgta tacatcccat ccaaatggag 3268561 gcaaagttca ttgctttcca cgtccgtttt tcctgtccca aaggcaccag atcttcattg 3268621 ctcagcctgt tggattgctg ctgactctct tttaatttca tagccggctc ccctttccat 3268681 attgtctata tgtcgtcaca cgttatgttt tttgacatta gatgtcactt aatataactg 3268741 aagagtcaga caataacact ggctatgata tacaattttc ccgtttgtat ttgaacagct 3268801 taaacaagaa aaagagacag acctcagagc ccgtctcttt cttaagatgc agttttcatt 3268861 aatgcagcaa atctcacagc cattaacagg cttgctccgc ccgctataat cataatgatt 3268921 cccatcatat caaaatgggc tgccgtgatt tctttaccaa aaagaatgcc aaggatcacc 3268981 gaagacaaaa tcgatcctag gtaacggcag gtttgaaaca ggcctgaagt cgttcctacc 3269041 atgttggaag gactcgtttc cagcatcgct gcctgaagcg cgacattgcc cagtccgtag 3269101 cctataccca agagcgacag aatgaggcct ttaccgatgg tctggacatt gataaaaaag 3269161 atggttaaga gcacggctcc agccgtcatc aaaagcgctc ccgcaaagat cggcttgacg 3269221 acaccagatc ggtcgatcca tttgccggtt agaggtgaca caacgatgct cattccagac 3269281 ataaacagca taaacaggcc gctcgtttga acagaaagat gcatttcatc ctgaaagtaa 3269341 cttggcaaac caaaaaataa acaatagaag aaaacattca ataaaataaa ctgaacatac 3269401 acggctgaca ggtttcgctg tgttttaaac agacggacat caataaacgg cttatccgtt 3269461 ttcagctcgc gccagacaaa cgcacagagc agaagcaagc caagcacacc ttcaaccgca 3269521 tgcggcgacg tgctgaacga cagcaaaaag gatagaagga aaatgattcc cccggcaaat 3269581 aaaacaattc caagaatatc gagctgccga ataatggttt tgattcctgc cccttttttc 3269641 tgatctttcg ggaacatata caggcccaat aagaagctga ggataataaa cggcaaatta 3269701 acgataaaga tcgccggcca gcctccccat acaatcaaaa acccgccggc tgtcggcccc 3269761 agcgccgtca tggcggacgc aaaaatagag agtacagcca aggctgaagc ttggcgctca 3269821 tgaatatgat tccgaatcaa gccgacacct gacggataaa tcgcactgct ccccaccgat 3269881 tgaaacagcc gcatgaccaa taatgtcata aacgtcggcg caaacggcgc cccgatggca 3269941 gaaaccgcaa caagaataag cccgaataaa aacaagcgtt tccgcccaat caaatcaccg 3270001 agctttcccg ttacgggctg cgctacggca ctcgccaagt aaaacgagga aatcagccag 3270061 gaaaccgttg taaacgagag gtgaaactca tgctggatgc tatggagcgc aagagagatc 3270121 atagacgagt tcagcggatt cagcattgtt cccgaagcca cagctgttaa aaaaacagct 3270181 cggctttttt tcgataacat catttcactt gttccagaaa ctcttccgtt gtccgcgatt 3270241 taccgattct cgggaaaata aagcgcagtg tggcttcatg ctcttcatcg ctaaatgtgg 3270301 acatggcatc tgtaataaaa atctgctgat agccaagctg aaatgcctcc cgtgctgtgc 3270361 tttccacccc gatattcgtt gcgatgccgc acaatacaat cgtatcaatg ccgcgacgtc 3270421 tcagctgcaa gtctaaatct gtgccaaaaa aagcacccca ttgccgtttt gtcacagtat 3270481 aatcgccatc ctgcacaccg atttccggaa caaattcggc ccagtccgcc ggcatttccc 3270541 ctgaacctcc ctgcgcaggc tcatccgttt gcggcttcag ggcgtccgct ccatcatgaa 3270601 aggctacatt tacaaagctg atgaacccgt tatgtttccg aaattcatct acgagctttt 3270661 tcgcgttcgg gacaacctgg ccgctttgat caatcggcac aattcccttt tgtaaatcaa 3270721 tgataaccaa tgctgttttt tgaaaatcaa tgttgagtgt attcatcata cgtctcctcc 3270781 tgatactgtt agtgtttctc acattgcata ttttactctt cacactgcct aagttctttt 3270841 atgatgcttg tgaaattctc agaaggagcg ttttctcatg atttttcttt tatgtagtag 3270901 taacaggttg tgcatacgaa caaaccggca agcactgtaa tcataaaggg cgtcatcgct 3270961 tcatcacctg cctgctgtct atcggttcct gcctgaaaat gcccatgaat ttgcggcggt 3271021 ccatccaaag caggataaga cacataacca ttaatatcgt gctaagatcc tgcacgccaa 3271081 tatcaaaaca atagttaatc aagacgatgt tcacaataat gggcataaaa ataaccgccc 3271141 ctaatgcagc cgttcgcgga atcagtaata aaacagctgc caggatttca ccaaaaccta 3271201 taaacagttc atagacatga gaataaccga aaaatgtcca cgcgatcgta aaccccttcc 3271261 cggcagccgc ctcgatttca ggcgtcacct cgccaaactg gccaattacc actttcgcca 3271321 gaccgtacac gaaaaaatta aaggctaaaa acaatcggaa cgtcgcggga atcgacttgc 3271381 gtaccgcttt cctcagcctg ccgcctttat tcatcataca tccccctcag tgtattattt 3271441 gatgtagtac acttaataca gtatagagta ttctaattaa tgtcaattcc cttttcagct 3271501 catatgaata gtttctttta tagatacaaa gtcttatatc gcaaaaaatg ccattctcct 3271561 tcctttccat ccctcgataa catttctcaa aaaccatgtc aggaaatctt acatgaaaat 3271621 gttttatcat tcttttttct ctataatgaa gaaatataat aattgctttt tattctgaaa 3271681 gatacggagg aatgagacat gcaaatgggc gatacagttt ttatgttctt ttgcgcttta 3271741 ctcgtgtggc tgatgacccc gggattagcg ttattttatg gaggaatggt aaagagcaaa 3271801 aatgtgctga gcactgccat gcacagtttc tcttccattg ccatcgtttc catcgtttgg 3271861 gtgctgttcg gatatacact tgccttcgca ccaggcaatt caatcatcgg cgggctggag 3271921 tgggcaggcc tcaaaggggt cggatttgat ccgggagatt acagcgatac catcccccac 3271981 tcgttattta tgatgttcca aatgacgttc gccgttctga ctacagcgat tatttccggg 3272041 gctttcgcag agcggatgcg attcggcgct tttcttttat tctcggtttt atgggcctct 3272101 ttggtttaca cacccgtagc gcactgggta tggggcggcg gctggatcgg ccagcttgga 3272161 gcgctcgatt tcgctggcgg caatgttgtt catatttcct ccggggtggc aggacttgtt 3272221 cttgccattg tgctcggcaa acggaaagac ggtacagcgt cttctccgca taacctcatt 3272281 tacaccttct taggaggagc tttgatttgg ttcggctggt tcggctttaa cgtcggcagc 3272341 gcattgacct tagatggtgt ggccatgtac gcgttcatca acacaaacac cgcggctgca 3272401 gccgggatcg ccggctggat cttagtagaa tggatcatta acaaaaaacc gacaatgctc 3272461 ggagcggtat ctggggcaat cgccgggctt gtcgccatta cgccggctgc cggatttgtc 3272521 acaccgttcg cttccattat tatcggcatc atcggcggag ctgtttgttt ctggggagta 3272581 ttctcgctta aaaagaaatt cggatacgac gacgcgcttg acgcctttgg cctgcacggg 3272641 atcggcggca catggggcgg aatcgcaaca ggattattcg caacaacctc tgttaactca 3272701 gcgggcgcag atgggttatt ttacggtgat gcaagcttaa tctggaaaca aatcgtcgcc 3272761 atcgccgcca cttatgtttt tgtatttatt gtcactttcg ttattattaa aattgtaagc 3272821 ctcttccttc cccttcgcgc aactgaagaa gaagagtcac ttgggcttga cttaacgatg 3272881 cacggggaaa aagcatatca agattctatg tgaggagtga cgctatgagc ggtcaaatgt 3272941 tcaaggtaga aattgtaacg cgtccggcaa attttgaaaa gctgaagcag gaactcggaa 3273001 aaatcggagt gacctctctg actttctcca atgtacacgg ctgcggcctt caaaaagcac 3273061 atacggagct ctatcgaggg gtaaaaatag aaagcaatgt atacgagcgt ttaaaaatag 3273121 aaattgtggt cagcaaggtt cctgttgatc aagtgacaga gaccgctaaa agggtgctga 3273181 aaacgggatc accaggtgac ggtaaaatat ttgtctatga aatcagcaat acgatcaaca 3273241 tccgcacagg cgaagaagga cctgaagcac tttaatatcg gtacgagatt cggacactcc 3273301 ggatctcttt ttttgtgcac agaatccccc cagaaaccgc gattcctctt cgaattctct 3273361 tcaagcgccg ttatttcaga caatctctat ttttatttga aacttttcat gagtaagatt 3273421 agtctactaa atataaaaat gtaaaaggtg attatttgaa ctacgaaatt tttaaagcaa 3273481 tccatggact atctcatcac aattcagttc tcgattccat tatggtcttc atcacggaat 3273541 atgccattgt cgcctatgcc cttatcctat tggcaatctg gctgtttggg aacacacaaa 3273601 gcagaaaaca tgtgctatac gcaggcatca caggaattgc aggccttgtg atcaactatt 3273661 tgattacgct tgtttatttc gaaccgcgcc cgttcgttgc gcatacagtg catacactga 3273721 ttccgcatgc tgcggatgct tcatttccaa gtgaccatac gacaggtgca ttagcgattt 3273781 ctattgcgat gcttttcaga aaccgcaaaa tcggctggcc gcttgtcatt tttgggcttt 3273841 tgacaggctt ttcgagaatt tgggtgggac atcactatcc ggtagatgta ttgggcagcc 3273901 tcgttgtcgc catcattatc gggttccttt tctttagatt ttcagatctg cttcgcccgt 3273961 tcgtcgattt ggtcgtgagg atctacgaag ccattatcaa taaactgacg aaaaaaccaa 3274021 ccgatcaaaa tttctaagaa agacaaaagc cggcgtctga aatcaagaca gccggcttta 3274081 atatttctca tacatctctt gttttcttcg cttcgccaac acatataaac cataaaacaa 3274141 cccaattcca acagcatcga tgagcacatc ccggatacaa ccattcctgc tgaagaagag 3274201 ctgaagaact tctgtgaaaa aagcaaacgc aaatgagccg gctgcagctg atcttatgct 3274261 gccccgctgt ttccacagca aatatgtcag cacaaagaag gaaaacgcgt gtccgatttt 3274321 ttgaataaac gcttcaggta cagtaagctc agtaaaatcc ataactaaaa attgagacag 3274381 atcagggtgc ggctgaaaat gaaaagccac cgtttgcgat acgaccatgc cgctgaagct 3274441 ttccgtacag acagaaagca ggataaaaaa gatccagcct gcgagcaata ggcggttcat 3274501 gacataacct cctttataac gtacgtgcct acatgtaact acatagacgg taaaacaaag 3274561 caaaaagtaa cagaaaaaaa cgcccatcac aaggatagac gttttcttca ttaagactgt 3274621 tcagtgtctt ctgttgtgct gctttcttta gaaccagatt tgtcagttga atcatccttt 3274681 ttctcaccgg atttttcttc tgttcctttt tcagttgatc cgtccttttt ctcggaagat 3274741 tgctgaatgg attcttctgt ttcttgggtg gcagcttttt caatagaaga aactggtttg 3274801 tccataaagt ttaacggatt cattgcaacc ccatctttac ggatttcaaa gtgcacgtgg 3274861 tttccgctgt cttcactgta aaggttcttg ccagattttc cgatcacttg attttgtttt 3274921 actttgtcac cttgctctac gcttacttcg gaaagagatt gatacacagt cgataaaccg 3274981 tcggcatgtt ctacttccac aacatatccc agcactggat ctttttcagc tttaacaacc 3275041 gtaccgctca gagaagcaga gacatcgaaa tcttttccgt ctttctcagc taagtcaatt 3275101 cctttgctta ggctgtacgt gttattatag gtaacgagtg ctgcttcttt ctcttctttt 3275161 gcggcatcgg tttcatagaa ctttttcaca acagaaacgt tttcagaatc aacaaccggc 3275221 attgcgacat tttccattga ctttcctact tcaactgcat cgtcgttgtt gtcatatgcg 3275281 gagtttccgc cgttatcagc caactgatcc tttacctcat catttgatac tgattgatac 3275341 caaaggacag ctgttaaaat gacggccgca ctgactaagt aaattgcagg gaacacccag 3275401 cgtttacgaa aaaactgctg aagttttttg acttgagaag ttttcttttc ttcctctctc 3275461 attgtttcat cacctcagca acattctgaa cacttttctg aaaatatata caacctatcc 3275521 aaaaaaactt ttttagatgt agtttgcaca gactgaacga aaatatgtat ttttttgaga 3275581 ggagtgccaa aaacgtatga acatgacatt gcgtcttgct gaacatagag acttggaggc 3275641 tgttgtggcg atttataatt caacgattgc ttctcgaatg gtaacagccg ataccgaacc 3275701 ggtaactcct gaagaccgga tggaatggtt ttcgggacat acagagtcac gtccgctcta 3275761 tgtggccgag gatgaaaacg gaaacgtcgc tgcctggatc agctttgaaa cattttatgg 3275821 aaggccagcc tataataaaa cagcggaagt cagcatatac attgacgaag catgccgcgg 3275881 caaaggtgtt ggatcatatt tgcttcaaga agcgctccgc attgccccga atcttggcat 3275941 ccgctcactt atggccttca ttttcgggca taataaacca agcctgaagc tgtttgaaaa 3276001 gcacgggttt gcagaatggg gactattccc cggcatcgcc gaaatggacg ggaaaagata 3276061 cgatttaaaa attttaggga gagagctttc atgattagtc tggataaaga tgaaaacgaa 3276121 attgaacatc ataatgaaga aaatagcctt gttgaacagg agactgcacc tgttggacag 3276181 gagagccgcc agctgagcgc ctccgctgtc aagtcgctat ccgacattgc caagtggggc 3276241 aaaatttctg gcatcttgtt aatcattatg ggatcgcttg tcactctgtc tgttttgatg 3276301 acagtgattg gcgccatccc gggcgtactg ctcattattt caggcgtatt tttgatgcgc 3276361 tcagcaaaag cagccgcgga agccgaagga aatctaaccg gcagcgctgg cgaaagcatg 3276421 cttgaaaatt acgggacatt tataaaaatg cagctgtttt atgcagcatc cagtatcgtt 3276481 actgtcctga tcgggatcat tgtagccatt ttcgtgctgg tggtaatcgg cattgctgct 3276541 tttgagaaca cgccttcgta tgatgatccg gattcttatt attatgagga tgatccggtg 3276601 tttgaataat gatgagacag gacagggcat gagttccata taaacggaac catgcctatt 3276661 ttatttgact attcaaagca ggccggcgta aacaccaaat cctgaagcaa gcatacaata 3276721 gacatctcta gtagaggaaa tcaacaaagc aacgctgtta cccagaaatg aatatcaaaa 3276781 aaacggatga agtcggaatc aatccgaaac cgcacttttt atttcgggtg tctgcatgca 3276841 aaaaaacaca cccggatcgt ctggaaaatc tcaacaatcc gggtgcagat cttctttaat 3276901 acattttttt gcgtctgtct tcctcagtca aaaattcaac aaaactccgc atcgcaaaag 3276961 gctcttcctt tatttgtcgt gcgtaggagc ttttccgctc ttctgaaagg atttcgctct 3277021 ttttgatcct gttcagcata tagatgtgaa ccgttttttg gatttgttta tgctgatagc 3277081 ctgcctcttt aaaaaatgcg agcccgagcg ccgccaaaag ggcgaatatg cctgcgctga 3277141 tcagggactc cctgtcagct gaagcatgaa atagaaaagc agctaaatta aagagagaga 3277201 atgcagcaag cggaatagca agaaaacggt aaatgacggt ttttttcatg aaaggctgta 3277261 cggccttttg aattttttgc atttctgttt tgatgaaccc cggcatttgt tcgactctgt 3277321 aaaagttcat ataatcctcc ccctttattt gatgtttcaa gcttcacgaa cgttatcata 3277381 tgtgtttatt ttaacgcagg tgcaagctgg ttttaaagaa atctgcccgt atttttcacg 3277441 aagaatctgg atcgccgctc tttattcttt taaaatgtga gtgttataat ttgtaatggg 3277501 aatcagatca ctgttattca tggaatacta atggcaatct tcttgataaa tatgaatgag 3277561 cggggttaca aagtgagtat ttcttccatc cttttatcac tttttttcat tttaaatatt 3277621 cttttggcca tcattgtcat cttcaaagaa cggcgcgatg ccagtgcatc ttgggcgtgg 3277681 ctgcttgttc ttttctttat tcccgtttta ggctttattt tatacttatt attcggccat 3277741 aatctcagac gcaagcattt gtttcaatgg gaagaccgga aaaagattgg aattgaaagg 3277801 ctgctgaagc atcagcttga agatttagaa accaagcaat ttcagtttaa caaccgggca 3277861 acctttgata acaaagattt aatttatatg ctgattatga ataaccatgc tgtgtttaca 3277921 gaggataatt cagttgacgt cattacagat ggacgggata aatttcagcg gctgctgagt 3277981 gacatttcaa aggctaagga tcatatccat ttacagtatt atatttataa aggcgatgaa 3278041 ttaggcaaaa aattgcggga cgctctcatc caaaaggcga aagaaggtgt tcaggtcaga 3278101 gtgctttatg atgaactcgg gtccagaacg ctgagaaaaa agttttttaa agagcttcgc 3278161 gaggctggcg ggcatgtgga ggtctttttc ccgtcaaagc tcaggccgat taacctgcgg 3278221 ctgaattacc ggaaccatcg aaagcttgtg atcatagacg gtatgaccgg ttatgtcgga 3278281 ggctttaacg tcggagatga gtatctaggg cttaatccga aattcggtta ttggcgggat 3278341 acgcatatcc ggctgcaagg aacggccgtg cacgccatcc aaacacgatt catccttgac 3278401 tggaaccaag cttctcatca ccatacgctg acatatattc caaatcactt tcctgattac 3278461 ggcccaaaag gcaacgtcgg gatgcagatt gtcacaagcg gccctgattc ggaatgggaa 3278521 caaattaaaa atggctacat caaaatgatt tcgaacgcca agcgttccat tttgatacaa 3278581 acaccttatt ttatcccaga tgcaagcctg ctggatgctt taaggatcgc ttgcctttcg 3278641 ggcattgacg ttaacattat gattccgaac aagcccgatc acgcctttgt atactgggcg 3278701 acactttcgt atatcggcga tctgctgaaa gccggagcca ctgtctatat ttacgataac 3278761 ggctttattc acgcgaaaac catcgtggtg gatgacgaaa tcgcttcagt cggcacagcg 3278821 aacattgatg tccgaagctt caggctgaat tttgaggtta atgcatttat ttacgatatc 3278881 accattgcta aaaaactggt ttcaactttt aaagaagatt tgctagtatc cagaaaattc 3278941 acctatgagg agtatctgca gcgcccgttg tggattcgaa taaaagaatc cgtctcgcgg 3279001 ctgttgtcgc cgatcttata agatgcgtaa acccccggcc tttacggccg ggggttttcc 3279061 tgatggtcac agtaaatgat gattgcctcc cgcaaaaaag cggcaagacc ttctccatat 3279121 tgattgattg aatcggtaaa tcgctcgtca gtgatataca cttccccgag tcctctgaaa 3279181 atgtcgagtg tgcaatcgta atgatattgg caaatatgat cgcgaaatgc ccccacagcg 3279241 gcctgaatct ctgcatcatc gggcccatgc ttcattcgcg ccgcaattcg tctgtaaatc 3279301 gaatcaaatt cagccatgat cgtgcgccaa tcatctgccg agtatgcaga tgtccttttc 3279361 tctgtttctt ctgcgatttc ctttccatac agctttctga cttcatcagc gtatgtctgc 3279421 tggtgctctt caatgtcttt catgcttaat ccggcaaata aatccctctt attcatcgtt 3279481 tcccctccat caacggacaa aagcgtcctg tcaattgttt gaatcatctc atccattctt 3279541 tgttttttct tcatcaatat ctccttttgc gactgaagtg ccgctttccg gtcaaaattc 3279601 ggatgatcca gcatctcttt aatctcatcc agacgaaacc cgatttcctt gaaaaataaa 3279661 atctgttgca gtctttccag gtctgcgtca ctgtacaaac gatacccagc atcagtaagc 3279721 gctgaaggat tcagaagctc aatattgtca tagtgatgaa gcgtccgaat gctaacgcct 3279781 gatatctccg ccacttgttt aacttgatat ttcatacata acacctcctc ttttttatcg 3279841 taaacaatca cgcaacgtta gggtcaatcc ccaaaatgtt attttctata tacaaaactt 3279901 ctcacaaata gtgtataaaa gaaaagtgag tatttttttg taaaggggag ccagtataca 3279961 tgaatcctga aacaatgaac aaaaccctca tcagcatttc gaaatgggga aaagctacag 3280021 gcattttatt tattattatg ggcgcaatta ccgcgctttc aggcgcgttc ttttttctaa 3280081 tcggtgccgt gccaggcgta ctgcaaatta tttccggtat ctttttgatg aggtcagcta 3280141 gggaagcagg ccaaatggct gaacacaata gcggacagtc tgaagactta atgctggaga 3280201 attacgcgaa attcgtaaag atgcaaggga tttatttgat cgtaagcatt gctgtatcca 3280261 ttcttgcgat tatcgccttc ttcatctttt taatgcttgg gattgctgac ggccttttca 3280321 gcgatacgta cagcacttat taatgagaaa aacccggagc tggctccggg ttttttatta 3280381 ttccgcttcg cttaccactg tgaagcgttc atttttgtgt tcgggatgtt caagctcgtc 3280441 caacacggca atggcataat ctgcatagct gatatagctg tctccttttg catttacgat 3280501 gacattgtct tttccttttt ggtaagagcc agtccgtttt cctgctggat caaaaaatgc 3280561 cgcaggactg aggaacgtcc aggaaatgga gtctgtctgc tgcaaatctt tcaggttctc 3280621 gccttgattt gatgcagttg gcaaatattc tttcggaaat tccggcgtat ccattaaacg 3280681 ggttgttttg gcttcatcaa caaacaggct tcccgctccg ccaacaacaa gcaatcttgt 3280741 gtgcttcgcg tcctttaaaa tgctgatgag tgctcttcct gcttcaacat gaagatgttc 3280801 ttggccgggt gctgctccaa aagcgtttac gaccgcgtcg aaaggcttga tgtcttccgc 3280861 agtcagttca aacacatctt tttccaaaat cgctacgtct tgctcctgca cttttgaagc 3280921 gtttctgacg atggctgtca cttcatggcc tctttttttc gcttctttca aaatctcgtt 3280981 tcccgctttc ccgcttgcgc ctataatacc aattttcatt tttcatttcc tccttatttg 3281041 taacaatttt agttacatgt tagcggtgag aagtcatccc ttttgattaa aagagatgat 3281101 tcataacatc ttttaatgac ttgcttgcca gttcattttc catcgctctt tgcacacttt 3281161 caaacgtttc atccagagcg ttctgaattt ttttccctac cggacatttc ggattcgggt 3281221 tttcatgaac cgcaaagagt tcttcttgct tttggacagc ccggtacact tctaaaagag 3281281 aaatatcagc aggatctttt ttgaggcttg cacccggcac cccggcgcgt gatgtgagaa 3281341 tatcagcttt tttcagcagg ctgatcattc ttcgcacaac taccggattc gtgttgacac 3281401 tgtctgcaat gatttctgaa gatgtttttt catccatcga gatgagggat aaaatatgaa 3281461 tggcaacagc aagacggctg ttaatcatgt tttttcacca ccgttgtaac tataatagtt 3281521 acatttgatt cgtttgtcaa catctaatat acactaaata catgggtttt gtgcaccgtt 3281581 tttagtcaat agaacggccg gatgcactcc ggccgcgtct tatcaaaata agaaatatct 3281641 ttgtccaagt gggacataat cgacaggctg gcaagacaat tcctccccgt cagcaaagac 3281701 ctgataggtt tttggatcaa tctcaatctt cggcaaagcc gaattcagct tcatatccag 3281761 cttgctcagc tttctgatat ttttgactgg agaaatcctt ttttccagcc ctaagctttc 3281821 cgccacacca cgctctatgc ttgcctgaga cataaatgta atcgaggttg agcggttggc 3281881 ttttccgtaa gacgcataca tttggcgcat gaaaaccggt tcaggagtcg ggatggacgc 3281941 gttcggatct cccatttgcg cacgtgcaat catgccgccc tttaagacca gttccggttt 3282001 cacgccgaaa aataccgggt cccacagaac gagatcagca agcttccctt tttccaccga 3282061 gccgacctca tggctgagcc cgtgcgtaat tgccggatta atcgtgtatt tggcaatgta 3282121 ccgttttgcg cgcacattgt cattcccgtt ttcaccggca agagcgccgc gctgtttttt 3282181 cattttatcg gctacctgcc atgttcggat gatcacttca ccgacccgcc ccatcgcttg 3282241 ggaatccgat gatgtcatgc tgatcgcacc tatatcatgg agaatatcct ccgcggcaat 3282301 cgtcgccgcc ctgattctgg aatggctgaa tgccacatct tcaggcactt tcgcatctaa 3282361 atggtggcag accatcatca tgtcaagatg ctcatccatc gtattaacgg tataaggaat 3282421 ggttggcgtt gtagatgacg gcagaatgtt cgcgtaagag gcgagcttca taatatccgg 3282481 agcgtgaccg ccgcctgccc cttcaatgtg ataagtatga ataacccggt ccccgatcgc 3282541 gtcgagcgtg ttttccaaaa agcccgcttc gttaatcgta tcggtatgga tggcaacttg 3282601 aatatcagcc tcgtccacga cttccataca cgttttaatg gcgcttggcg tcgttcccca 3282661 gtcttcatgg agcttaagac cgatggcgcc tgcttccacc tgctcgatca gcggcgcttt 3282721 atcggatgca ttcccttttc ctaagaagcc gacattgatc ggaaactcct cggccgcttc 3282781 cagcatcctc gccatatacc acgccccgga cgtacatgtt gtcgctttgc ttcctgtagc 3282841 gggtcctgtt ccgcctccca aaagggtcgt cacacctgaa gaaagcgcaa cttccatctg 3282901 ctgaggacaa ataaaatgaa tgtgcgtgtc cactcccccg gctgttaaaa ttttgccttc 3282961 accggaaatc acctctgtcc ccgctccgat gaccatgtgc ggatcgactc catccatgat 3283021 atcaggattt ccgctttttc cgacaccgac aatccggccg tctttcacac cgacatccgc 3283081 tttgacaatg cctgtgtaat ccaatagcac gacgttggtg ataaccaaat ccaaagcgcc 3283141 gtccttccct gtgattctgc cgttttggcc catgccgtct cggatagttt ttccgccgcc 3283201 aaagatcatt tcttcaccgt atactgtgaa atccttttcg acttcgatcc ataaatccgt 3283261 gtcgcccaat ctgattttat cgcccgttgt cgggccaaac agttccgcat attcctcccg 3283321 tgacattttc atcggattac accctccatc cagccggctt gttttaagtt ggccaacgtt 3283381 ttttctttgc cgcgttcatc gataaacgtg tcggccattc cgttcagccc tctaattgtc 3283441 ttgcgtcctc tgatttccac tagtgagacc gttttctgct ctcccggctc aaaacggacc 3283501 gacgtgcctg atggaacatc aagacgcatg ccgatcgcca gctcacggtc aaataataaa 3283561 gccccgttgg cctccgcaaa atgaaaatgc gaaccgactt gaatggagcg tgatccggtg 3283621 ttttttaccg ttacctcccg tatctcacgg ccttcattaa tcgtaatggt tccctcagca 3283681 atttgaaatg ctcccggctt catgacttca cctccgcaga aattggctga tgtaccgtaa 3283741 caagctttac accatccgga aatgtggcct ccacctgaat gctgtccagc atctcaggca 3283801 caccctccat cacatctttt tccgttaata catggcggcc ggcttccatc agctctgcta 3283861 ctcccttccc atcacgtgcg ccttccataa taaagcaggt gatataagca gcagcctcag 3283921 gatagttcag cagaacgccc cgcgcctttc gctgtttggc taattccccc gctgcaaaaa 3283981 tgagcaattt ctcttgttca actggtgtca gtttcatctg tagtcctcct tcttttgtca 3284041 tataaagcag atgcggctac tacgaatttg cggaacagtc aggcgggaca tcacctccct 3284101 ttcttcgaga atgggggtca tacggtaaga tgcctttcaa agcggcatgc cgtttcttca 3284161 tcagccttgc catggtcaac aaccgttccc ctgtcgatca cggaaagatc agattaacgc 3284221 gttttccaga ctgcgctcga ctaagataac aaatgtcttt ttttctggaa atttctataa 3284281 taacttgtct gactagttcg acaattaaaa tctgaattcc ttccaattgt ttattaagta 3284341 aaatattttt cagatttacc atcagcgctc tggtgattgc aagctgctgc tgttgaccgc 3284401 cttttcgttt tgaacaaacg tttgattaaa acaaatagcc ccctctgttt agccggagtc 3284461 ggcctaatac agcgacaatc tgccccgggc gaagctaagg ctgtgcaaaa ccatcgattg 3284521 atcataacca gacgttacat tcctgatggc agcccgttgt tttgctccgc aaccggaagc 3284581 atggcatgga ggccagtctg aggcgccgac ctccacgata ccgagaaccc gactattgcc 3284641 attaactccg catcatggac ggtcacttcg ctgatcgcca ccgttcctct taatgagtga 3284701 agaattccgg ccttcactga atccccgctt gtgtcgatat caactgtttt ctcgcactcc 3284761 cgtggcttcc gacactttct tcggtgcagt acattccgtc atcaaaaccc ctttgtttga 3284821 tttcttcaaa tgatgttata aaagtttaca acttatgtca tcattatata gaagaggcct 3284881 attaattcaa agaatattta aaaaatttag ttaccttgac caaatcagct tctttttttg 3284941 ttatatttat tcacatcaga aaaagcgaaa aaaaaagaca agaaacattt cgtttcctgc 3285001 ctcttccgta cgattaatct ttatctgaaa atttatcctt ggctttcccg atatcctttt 3285061 ggatttcgcc ttttgcctta tcttttttgc cttcagcctg catgtccgtt ctgtcagcca 3285121 tatctccgac tttatccttc acttctcctt tggctttatt gaagccgccc ttcattttgt 3285181 cttttacact atcgttaccc atgttaattc tcccctctca attatgtgtg tacttgttaa 3285241 cttcccgatc tgagaggcaa taaacattct aatgttattt atcgatttcg tagcgctctc 3285301 cgtaacggag caccttgtat atcgccagcc cgtctgatga ctttttctcc gaatatcgga 3285361 ccggcagcag ggcaaaaaac acataatacg tagaaaaata gacaaactga tagaaaaaca 3285421 cattcggctt taatacactg tgtataatca gcagattgat tgcaaaaatc gtgatgaggt 3285481 taaacaagca gccccctgca tacacgagtg catttgagaa tcgattgtca attttcaact 3285541 ccccgtaccg gcaaaaagaa tcgataaaat aaatcgttct gaaccgtatg ggtccaattt 3285601 taagcagcgt ttttcccatg cctatatcca acgatccctt tccgccaaaa ataaaagcca 3285661 taaagctgtg ccctgaaaca tgtataatct gtacaagcgg cagaacaatg aggaaagacc 3285721 acagaaactt caccatatca ttaaaaccaa acattgaatt ccccctcaca tgcatatctg 3285781 catcccaaaa cggcttttgt tcaaaaaaca gtgctgtagc gatttttcct gttctccccg 3285841 gaaataaacg ttccgatgct cccctttttt tgcataaaaa aaaaccatct gccagcagat 3285901 ggttttgtct catacttcat ataaacaatc gttcctttga atcatctctc tcatgctgac 3285961 cgctttttca taaaaataca ccgcttcttt atattgttcg cgatgactga aataagaggc 3286021 agcatctaaa gcaaattctt caatatatac atacaggccc ttttcttcca tataatcaaa 3286081 tacttcttga atcatattca aattgacaga ttccacatat aatgcctgca gaaatttata 3286141 ttttgccaga ctgaagaagt cgtttcgttt ttgggcaatg gcaatccctt tttcatagta 3286201 ccgtatcgcg gcttcgctat cttgtttttt gaaaagaacg cgagtcaggc tgaagagcgc 3286261 ttttggaagc tgttccagct gataatcctc gaagacagga agcgcttttt caaagtattc 3286321 ggcggcctga tccagctccc ccttgtcatc atagcaatta ccaatattat aaagggctga 3286381 tccgatcaaa cggggctgtc cttccaataa agcaaggcga tacgcgtcat ctaaatgttc 3286441 aagcgctttt tcataatttc tgtagtcaat gtagtttcct gatatgacga aatggcattg 3286501 aattcttctg actctgtaaa aatcgtgagc cttatacgtc tccagcgcct gtacggcatg 3286561 gttcatggaa aagtgcgtct gcttcataat ataaaagact tccgccactt taaaatgaaa 3286621 ttccgctctt tcaatttcat cttctacaaa cgcaagcatc ttctcagctt tccgataaaa 3286681 ggatatagcc gagatgtaat tgttctgttc aaattcgtac attcctctaa acaagtgaaa 3286741 ataatactca gataatccgg agatgctgtc ctgattgctt tccagcgttt tgatcaattc 3286801 acgatattga agctgagatt cctcgtgcag gtcaggcttt acataatcca gcataatttg 3286861 gtgccggtag ctgatcagct gataatacag gagaagcagc tgatcctctt ccatctgttc 3286921 gatatctaga tcaatttctt ctttcagttt tacggcatca gccacttgaa atgctaaaat 3286981 gtgcttatac cacttattga ttttcactcc tacttgagat gacgggatct cgtacgcggc 3287041 catgcccctc caaccctttc tattttctaa ttggttatat tttatcataa tgtatggctt 3287101 tggaattaaa ttttcttaca atgattcctt ctttatgcct atccttatat atttcggttt 3287161 ttctacgtat tttttgcact cggattctaa taaaaaagct taccggacag tgccgataag 3287221 cttttgactt caaattaacc gccaatataa gacatttcca ctttcttttt gccagatgct 3287281 tttgatagcg tacgatcgac tgaatactga tcgatccgat ttttccatac tgtcccgatc 3287341 atttctgata gttcgtcatc acttaattcc tggcgaaccg gagctctgag gtcaaatccg 3287401 cttgaagcga ataagcaggt aaacagctct cctctcgcag aaagacgggc tctgttgcaa 3287461 gatccgcaga atgcatcaga tacagatgat atgacgccaa tttctccgga gccgtccaag 3287521 tagcggaatc tggaagccac ttcgcctata taattaggcg ctatcggctc aaccggcatg 3287581 tgtttattga tcaaatctat gatttccgcc tttgtcatga cgtctttctt ttcccattgg 3287641 ttggtgttgc ctacgtccat aaattcaatg aatctcagga tatgcccttt ttctttaaaa 3287701 taacgggcca taggcagtat atctttttca ttgacgccct tttgaacgac catattgatt 3287761 ttaacaccga gccccgcttg cttcgccgct tcaatgcctt ccagcacctt gctgacagaa 3287821 acaccgcgcc cgtttatctt cttaaaacgc tcgtcttcta aagaatcaag gctgatcgta 3287881 acccttttca gcccagcctc cttgagcctc ttagcataaa caggcagcag tgatccgttt 3287941 gtcgtcatcg cgatgtcacg aatacccggt atgcgggcca gttttttgat taattccggc 3288001 atatcctttc tcatgagggg ctctccgccg gtcaagcgga ttttttcaac gccaaatctt 3288061 gtgacaaaca atgtcgcaag ccgttccagc tcctcaaatg aaagcagctc ctctttcttt 3288121 aaaaaaggat aatccgggcc gaataattcg gcgggcatac agtacgtgca tcggaagttg 3288181 cagcggtctg taacagaaat gcgaaggtct ctcagcggtc tgtttctttt atccaacatc 3288241 tgacgcgact ctgtaatcat agctacagcc ccttcctact ccctgattct ctcagggtgt 3288301 gtatatacat taaatgatcc gtttctgaca aatccaatcg ctgtgatatt caattcttca 3288361 gccatttgaa tcgcaagctc cgtcggggcc gatttggaaa tgacaatcga cacgccgatt 3288421 ttggccgctt ttaacaggac ctctgatgag attctgccgc tgaacacaat cagtttgtcg 3288481 cgtacggaca tcccgtttag aaggcagtgt ccgtatagtt tatcaagtgc gttgtgccga 3288541 ccgatatctg tgcgcatcaa cagaagcttc tctgtgtcgc aaagcgccgc attatggacg 3288601 cctcccgtat cctgaaacgt cccgctccct tgctgcatgt ctttcataag cgccagacat 3288661 gcctcaggcg atatcttgat ttggctgaca gccgtcttgg ctgttttgac atcctgctga 3288721 aaataaaaat gacggccctt tccgcagcat gagccgatca cccgtttcgt ataatccttt 3288781 tgatccaatg tctcagggtg aacgaggtcg acatatacaa aaccgagact ttcatctatt 3288841 gtaaaccttt taatttcttt ttgaaatcgt ataacaccct ctgatgcgag aaatccgatg 3288901 acaagctctt cgatatgctc aggcgtacaa acgagcgtca caaattcact gccattcagt 3288961 atcactgtca aagggaattc cgtcaccatc cggtcttcta ctttgcttat ttccccttgt 3289021 tcatagcgcc atacatccct gaccgcagtt actttatcgt tcaatgtctc ttcccctccg 3289081 caatgttcct gcctttatat tttttcacac tcctcggatt ttgtcgaatt ctgagacaca 3289141 aaaagagccc tctatataaa gggcttttac aggatgtgat gacggcggtg tttaggcagg 3289201 acgcctaagc atttagccgc cgttcctttt ataacacgtg agcaccaatg tgcattgaca 3289261 acgaacgcgg ggtttgtcga cacgctgaga cacctctgta taaaggactc tatgtttgat 3289321 tatgctgatt ctttttcaga accgtaaaca gcacaatagc tgcgatcaag gtgagaatgc 3289381 tgacaaaaaa gaaggctgcc agttttagaa gaacaccaag caatataaat gcaacggtgg 3289441 ctataagaaa aatcattccg aataatttca tatgttcaac ccctttttag ggtatcattc 3289501 ccgcccaaac tgtttttaaa ccaataaaaa aggcgcctgg gggagcgcct gatctttagg 3289561 ttccttactc agtaaatttt tgtgcttctt tttcccaagc ctgttcgaac tcatccgcac 3289621 tgttcgctga aatatattct ccgccgccag cgacagctgc ttgtttcatc tcttcattac 3289681 ccttgacatc aaagttgaag ccaatgatgt ttacaatcgt atccacattt gatgcacgga 3289741 gcttttcgat ttccgccgca gggtctccgc cgcacgtttc ttcaccgtca gtgattaaat 3289801 acaccacgtt tttcccgtct gcgtcaaatg cttcaaattc ttttcttgtg tctgcaagtg 3289861 ctttggcaat cggtgtccat ccagtcggct tgagctcact caatgaattg tcaaacagag 3289921 acccttcata tggatgaagg ccgtaaatgg tttccgtcgt actgcacgaa agggctttac 3289981 cggacagttt attgttccct gcatgcccga aaacgcgaag cataagattt gtatcctttg 3290041 gaagaagttc ggcaaaagat tttactgatt ttttggcaat gtctattttg cgctctcctc 3290101 ctgttttttg aaccatgctt ccgcttccgt caaacaaaac agctacattt gtatcagcct 3290161 gtttctcagc ggcaaaagac ggggaggcaa tggaaacagt caacaatcca atgataccgg 3290221 cagccagcaa ttttttcata tgattacttc ctttcttttt catattttcc aactatatgt 3290281 tggattcttc tttatgctag aatacgaaaa tgcaaaaaga tataggacat gctgcctttt 3290341 gtgctgcttt cacgatctgt ccaaaatcgc ttgaaatgcc gttcattttt agccatttcc 3290401 gcccagaaag cataaacagc ttgtgtgatc attcattctt ttttcgcctt gattatgaca 3290461 gaaaaacgga aatctgctac tatgctacag gcagacagct aattagtttt gaagtttttg 3290521 ttacatacaa aaagaggctg accatcacca gcctcttttt tcttatttag ataacattag 3290581 tgattgctga gtgaaaattt tctcaacatc tttttgggta taagccggga agtattcacc 3290641 gccgcctact ttcgcaattg cgttcagctg gcctttgtat ccctctttat aatcaaagcc 3290701 gatcacatta acagtgatat tgtctttttg cagttccttt gctgttttaa tcgggtttcc 3290761 tccgcacgtt tcctcaccgt ctgtcaacag atacaccact ttttcccctt ttgcatcaag 3290821 ctggtcaaaa gaagatttcg cctcgttcag cgctttggca attggcgtcc agccagtcgg 3290881 cccaattgta ttgagagaat tgaggaagct ttgctcgtta aagctttgga agccgtatac 3290941 gttgcgaatg gcttcacatg actgaacttt tccggaattt ttattgtttc cttcagagcc 3291001 aaacacgctc attttcacct gagttccttc tggcaatgag ctcgcaaact ttgaaatttc 3291061 ttttttggct gaattaaatt tagatacacc atctattctt ttcgccatac ttccgctggc 3291121 atcaagcaag accgccacgt tcgccggcgc tttagcctcc gtttctgtct tttcagctgc 3291181 aaaagcaggt gaagttaatc caaaaagcaa tcctgtcatc atgatcagtg aaaatctttt 3291241 cttcatgttc gtaccccttt accaatttgt ttctgcgtgc agatgttcaa cgctgaacat 3291301 aatctatcgt aatcaacaaa aaccgagaaa taaatagggc gggcttcccc attgctgttg 3291361 tttacttttg catagaaacc tatgttttta ttagtgattt ccacctaacg cccctatgaa 3291421 aagagaagat tgtccgcctt tcggctttcg ttatatgagt ctgtcgaagt ctgtcgacaa 3291481 atgtggatga ctttaccaca atctcaaagc ctgaaatcag gaaaaaagga ctgatcctta 3291541 aagacggtca gaagctcctc taaaccgttt cagctactct tagataaaag atattcagga 3291601 acagaaaaag acgcccaatg agcgtctttt tctacttttt cgccatatat ttattcaaaa 3291661 acgcatctgc ctcagaaatt tgtgtgcctt ggtaatagta ctttacaatg tcatcaaccg 3291721 ttttgccttc tttggccata aaattcgctc cgtattggct catccccaca ccgtggccaa 3291781 atcctctcgt cgtgactgta attgtgtctc catttcgctt ccattcaaaa tcggcggagt 3291841 tgagacccaa cttttcacgt atgtctcttc ctttcagcgt cttgccgtta atgacggcag 3291901 ttgcgacctg gtggcccggt gtctcgccgg taatcttccc tactgcgcta gatccatcca 3291961 gcttgacgcc aagcttttgc tgaaattctg ccgctgtaaa ggttttcgtt gccttatatt 3292021 tcggagactt tttatcccat gggcttttga cgctttttaa atatgggata gcacttgtcc 3292081 aataagcttc tgcattctct gtgtagccgt tgcttgtgga gaaaaaggat gcttcaatcg 3292141 gctggttgtt gtacgttaag attttgcctt gcgtactggc taccgcatct gtgattttct 3292201 tcagttttgt ctcatagctt gtgccccact gttttttcag ctccgctttg cttttataca 3292261 cctggaacat ctgtgtatca tccaccagtg agcctttagg agcttctacc gctgaatttg 3292321 acaccatcag tctgacaata aatgttctgg cggcaagcgc ctgggctttc agcgcttcag 3292381 gtttaaaggt tgccggcatt tcggaggcga cgactccaat cacatactct tcaagcggaa 3292441 tgttttctac ggattgattt gcggttcgat agacgggaat agaaacaggt gatgctttca 3292501 atgtttctgc tcctttcgat gctggtttcg tgctgactgc tgtcttttct gattctacgc 3292561 tggcccccgc ttccttatta tgctggaatg gtataaccaa gagtgtggga accaagagaa 3292621 tcaatgcaca tagtacggat agtgtgattg cgaattgttt catattcagc tgcctcctgc 3292681 tcgggattcg actctagtct agtctatggg cagggacaag ctaatatgac tctcgttttg 3292741 gacagaaact ttatttgtca tttacgtatt cttttttgct attttgcgca taatgatgat 3292801 aatacacaaa aaataaaaaa ccagtatgcc agagtgacat actgattttc aagtaagttt 3292861 atgcatttaa gtcagaaacg acttctttat tctcttgctc agaagcagac tcatcattta 3292921 cacgttcgat gtctgcgccc agagcggcaa gcttctgatg gaaatcaacg taaccgcggt 3292981 ctaagtgctt caattcagta acacgtgtgt gaccttcagc cactaacccc gcaagaatca 3293041 gcgctgcacc tgcacgcaaa tcagtcgctg caacttcagc tccctgaagc tgtacaggac 3293101 cgttaatgat gacagaacgt ccttcaatct tgatatcacc attcatacgg cggaattctt 3293161 ccgcatgcat aaaacggttt tcaaaaacgg tttctgtaat catgcttgtg ccgcttgcac 3293221 gaagcagaag cgccatcatt tgtgactgca tatcagtcgg gaagcccggg tgaggcattg 3293281 ttttgatgtc aatcggttta agctctttcg ggccgatgac acgcagacct tcaccttcat 3293341 ccttaattgt tacacccatc tcttccattt ttgcaattaa agaggtgagg tgctcaggaa 3293401 ccgctccttt tactaatacg tttccttcag tgattgcagc agcaaccata aatgtgcccg 3293461 cttcaatacg gtcaggaata atatggtgtt ttacgccgtg aagcttttcg actccttcaa 3293521 ttttgatggt gccggtgcca gctccgcgga tttttccgcc catgccgttg atatagtttg 3293581 ctaaatcaac gatttcgggt tcttttgcca cgttttccag cgttgttgtt ccttcagcta 3293641 gagcggctgc cataatcagg ttctctgtag ctcctacact tgggaagtcc agataaattt 3293701 ttgcgccttg cagtcggcct tttacttcag cttcaatgaa gccattaccg actttgattt 3293761 ctgcgcccat tgcttcaaaa ccttttaaat gctgatcaat cggtctggaa ccaattgcgc 3293821 atccgcccgg aagtgcaact cttgcatgac ctgtacgcgc aagaagcggc cccatgacaa 3293881 gcacagacgc acgcatttta cgaacatatt caaaaggtgc ttcagtttgc aaagcgtatg 3293941 aagcatttac agtcacttca ttattttcaa aatgcacatc tgctcctaaa tgacgcaaca 3294001 cttcgttaat tgtatataca tcggagagcg taggtacatc acaaattacg cttttttctt 3294061 cacttgctaa taaagatgca gcgataacag gtaaaacggc atttttagcg ccttcaactt 3294121 tgactgtgcc gtttaacttc tgaccgccgc ggacgatgat tttttccaag gtattcccct 3294181 ccgcgtccct aaattctcta tattaatatt cagtcgtaac gattggtgtg ccaaccgtaa 3294241 cggtatgttt tccgcccatt cctgcacttc taagtgcaat ttgcaaattc attttatgtt 3294301 tcgaggtcat aatgtactct tcccactcat ctgtaaacgc agaaatagaa acgaaatttg 3294361 gctcaactac atgttctact gatcttgctt gaaattcatt taataactga tttgcttttt 3294421 tttgcaaaac aatattcata ttatcatcta agtgaccatt tagacaagta aaaataacta 3294481 ctttttcttg gaatatccca agtgtctccc gttcaaactg ttcatatgta tcattccagc 3294541 tatccggtgt ctctagactc atttgctcat ataataaata cgaagttgga ttgtgttttt 3294601 tgagggttgt gacaagctgc agtctaaaag aagtacgatt ttttttgtca gtatatgtgc 3294661 caattgcctt tatcatttta tcttcccgtg caatcaccca atcatattga cgatactctt 3294721 gttttaaacg ttgcactttt tgataaaatt ctttttcggt cagtgacaag ttttgttttg 3294781 catgcaatgt ccacttatct attgacacat cttgacgttc catcccctct gccatctgtg 3294841 ctaacggcgt taattcactc gcatgaatgg tatggaaaac agcaatgacg aagcttaaca 3294901 tgacggaaat gataatagcg tggcttactt gttttttctt catgttcatc tctccccctt 3294961 atccccagtt ttaccggagg caagaggcgc catacgtaaa aatcttcgtc aaaactcgag 3295021 ctattcgctt caacccgctt ctcccaacca tttaataatg ttcaaaacct attaaaatag 3295081 atagggaagc tgctgtgaat aattgaggta atctaaaaag aaattggcaa cggccgttcc 3295141 aatggcgatt gtcagcaaaa tcatcaggag tcttgcctgc acgactttgc cttttttgat 3295201 taacggatct atattgacgg cttgcaacgc ccaccaagtc actgctataa aaatcaggtg 3295261 aacgacaatg ccgattgcag cctgctgtcc caatacactc atctattaca ctcctttctc 3295321 tgcgttcata ccctttctta ttatataaga agcacagata aagatgatac attttataca 3295381 gaacggaata atcagccaaa tctagggcta atccccgctt aaagtgcgat tcttttacat 3295441 ggtatacttt attggaaagg agctggcaaa tgtgaatcat tctttttttc agcctgaaaa 3295501 gcaatatggt gaggacctgc caatttttga tcaggaatgg gaagcaattg cattctatta 3295561 tgattataga cagtcacaga ttgaagaact gaatgaattg tgtcagtttt ttaacatttc 3295621 tcttacctat acgagagaaa gccttgaaga gcttgaaaac ctctattttc aaagtataca 3295681 agaacttttg cttgctgatt ggaatcttcc tattgaagaa ttcgagaaaa tgatcagtgt 3295741 ttatcttata gattgtgtga ttgcccgcca tgaagatgct gaatgggttg taaaacctta 3295801 tccctataaa gacggcgctt atacacttgg ctttagaaga catcgcaaat cgtggcatac 3295861 aatgaatgcc tgtgatggtt tatacctgcg tccaaaagag gatcgcccgt tgctgtcgct 3295921 gtttgattct cttgtgcgtt cataaaaaaa tccttctcat aaagagaagg attttttctt 3295981 atttccctgc tacatccaat ctgttcaaag cccgctgtaa cgcaagctca gcccgacgaa 3296041 tgtcagtatc atctgattga gaattcaaac gctcctgcgc ccgctggcgt gcagcttcag 3296101 cgcgctcttt atcgatgcct tccgctgtct cggcagcctg ggcaaggatg gtgacatgat 3296161 caggacggac ttctacaaaa ccgccgctga cggcaaccat ttcagtctgc ccgtcttttt 3296221 tcagacggac agcgccgatt ttaagaggag ccacggttgg aatatggcct ggcaaaatac 3296281 cgagatcgcc gctttcggct ctcacactca ccatttcgat atccgcatcg tatactgggc 3296341 cgtcgggagt aacgatattg actttaacgg tcttcatgct tttaccctcc taggaccaga 3296401 ttaaacttct acacccattt cttttgcttt ctcaacaact tcttcgatac ggcctacaag 3296461 acggaatgca tcttctggaa gatggtcata tttaccggct aagatttctt tgaagccttg 3296521 taccgtctct tttacaggca cgtaagaacc tttttgtcca gtgaactgtt cagccacgtg 3296581 gaagttctga gaaaggaaga actggatacg acgtgcgcgg tgaacgacaa gtttgtcttc 3296641 ctcgcctaat tcatccatac cgagaatcgc aatgatatcc tgaagctctt tgtaacgctg 3296701 aagcgttgac tgtacttcac gcgcaaccgc atagtgctct tctccaacaa tttcaggagc 3296761 aagggcgcgt gatgtagatg ccaacggatc aaccgcaggg taaataccca tttcagttaa 3296821 tttacgctca aggtttgttg tcgcatccaa gtgagcgaac gttgtcgccg gcgccgggtc 3296881 agtgtagtca tcggcaggca cgtagatcgc ctggatagat gtaactgatc caacgttcgt 3296941 agacgtgata cgctcttgga gctgacccat ctcagttgca agcgtcggct gataaccaac 3297001 cgctgaaggc atacggccaa gaagggctga aacctctgaa cccgcttgtg tgaaacggaa 3297061 aatgttatcg atgaagaaca gtacgtcctg tccttgtaca tcacggaagt gctcagccat 3297121 tgtaaggcct gtcaaagcaa cacgcatacg tgcgcccggc ggctcgttca tttgtccgaa 3297181 taccatggct gttttgttga ttacgccaga gtcactcatt tcgtagaaaa ggtcgttccc 3297241 ttcacgagta cgctctccta cgccggcgaa tacagagata ccgccgtgct cttgcgcgat 3297301 gttgttgatt aattcctgga ttaatacggt tttacctaca ccggcaccac cgaacaatcc 3297361 gattttaccg cccttaatgt aaggagcaag caaatcaaca actttaatac ctgtttcaag 3297421 aatttcaact tctgttgaaa gctgatcgaa tgaaggcgcc tgtctgtgaa tcggatcctt 3297481 tttcgcatcc gcaggaaccg gctcattcaa atcaatattt tctccgagaa cgttaaatac 3297541 acgtccaagt gttacatcac caaccggtac tgagattggc gctcctgtat ctacagcttc 3297601 cataccgcgc tgaacaccat ctgtagatgc cattgcgatt gtacggactg tatcatcacc 3297661 taaatgaaga gcgacctcaa gcgttaaatc aatacctact tcgttttcac ttgcagctgg 3297721 ctgtgaaatt ttaatcgcat tataaatttc aggcaagtga ccgtcttcaa aacgcacgtc 3297781 gacgaccggt cctaatacct ggctaacgcg tcctttcttc atcgctatcc ctcctgacaa 3297841 aatctttcta ttctaaagcg gctgctccgc cgacaatttc cgtaatttct tgtgtgatgg 3297901 ctgcttggcg agcgcggttg taagaaagcg aaagtgaatc gataagttcc ttcgcgttgt 3297961 ctgtcgcgtt tttcatcgcc gtcattcttg cagcgtgctc acttgcttta ctgtcaagaa 3298021 gcgcaccgaa gattaagctt tctgcatatt gaggaagcaa aacctccaga acctcctctt 3298081 cagatggttc aaattcataa gacgccgttc tttttccgcc gccgctgccc aaatcagata 3298141 acggcagaag ttttttctcc gttacttctt gagtaatggc gctgacaaaa tggttataaa 3298201 caaggtgcaa ttcatcaaac gcaccgtcta taaacatttg aatcgtttga cgggcaagat 3298261 ctttaatttc tgtaaacgtt acttcatctc caagtcctgt taactcggaa atgatcggaa 3298321 tctcccgttt cttaaagaaa tcacggccca ctcttccgat ggcaatcacc gcatactcat 3298381 ccttagactg atgacgttct tgcatggcct gataagcact ccgtaaaacc gaactgttaa 3298441 aagcgccggc aagaccgcgg tcagacgtaa tgacaaggta tgccgttttt ttcacttctc 3298501 tgctgagaag catcgggtgc ttcacgttgc cggaaactct tccgacgttt gacacaacct 3298561 cttggatttt atccatatat ggcacaaatg attttgcatt gttttcagca cgattcagct 3298621 tagccgcaga taccatctgc atggcttttg taatctgact tgtttttttc gttgacgtga 3298681 tccttgactt aatatcgcgt aatgaggcca aagatttcac caccttttct cttcatctgc 3298741 gtaaaaagag agaaaaagag aacctttttc tctcatcagc attcgagtta gttgcttggt 3298801 gcaaatgtgc gtttgaagcc ttcgattgca gctttgaagt cttcatcagc aggaaggttt 3298861 cctgttttcg caattccgtc aagcaggtct ttatggtttt ggtcaaggta catgtagtac 3298921 tcttcttcaa aacgtctgat atccgccaca ggaatatcat cgagatatcc ttttgtcagc 3298981 gcataaagaa tagctacttg cttttcaacc ggaagcggct tgttcagatc ctgcttcagc 3299041 acttcaactg tacgcgcacc gcggttcagt tttgcctgag tcgcttggtc gaggtcagaa 3299101 ccgaattgag cgaatgcttc cagctcacgg tatgacgcaa ggtcaagacg caaagtacct 3299161 gatacttttt tcatcgcttt gatttgcgct gagccgccga cacgggatac agacaatccg 3299221 gcattgatcg ctggacgtac gcctgagaag aacaaatcag attgcaggaa gatctgtccg 3299281 tcggtgatgg aaatgacgtt cgtcggaata taagcagaga tatctccggc ttgtgtttct 3299341 acgaacggca gagctgtaat tgatcctgcg cctttcgcgt cgctaagctt tgctgcacgc 3299401 tcaagcagac gggaatgaag atagaataca tccccaggga acgcttcacg gcctggcgga 3299461 cggcgaagaa gcaaggacag ctcacggtaa gcggccgctt gtttagaaag atcatcgtat 3299521 acaacaagaa cgtgcttgcc gttgtacata aattcttctg ccattgtaac cccagcatac 3299581 ggtgccaggt acagaagcgg tgccggctgt gacgcagacg ccgttacaac aattgtataa 3299641 tcaagcgcgc cgtgtttacg caatgtttct actacgccgc ggactgttga ttctttttgg 3299701 ccgatcgcaa catatacaca gatcatgtct tggtcttttt ggttcaggat cgcatcgatc 3299761 gcaacagatg ttttacctgt ttgacggtca ccgatgatca gctcacgctg gccgcggccg 3299821 attggaatca gtgcatcgat cgctttgata ccggtttgaa gcggttcatg aacggattta 3299881 cggtccataa cgcctggtgc agggctttcg atcggacgag ttttgcttgt cagaatcggg 3299941 cctagtccgt caaccggctg gcctagcggg tttacaatac ggccgattaa ctcttcacca 3300001 acaggaacct ccatgatgcg gcctgttctt tttacttcgt ctccctcacg gatctcactg 3300061 aaaggtccta agatgacgat acctacgttt gattcctcaa ggttttgagc catacccaaa 3300121 acaccgtttg aaaattcgac aagttcaccg gccatacagt tgtcaaggcc gtgcacacgt 3300181 gcaataccgt caccgacttg gatgactgta cctacgtctt gaacttcaat atcagattga 3300241 taattttgta tttgctgttt tatcagcgtg ctaatctctt cagctttgat gctcacttag 3300301 gtttcacccc ttctatcgat tttccccggc taattgacgt tcaatgcgct gaagcttccc 3300361 gcttacgctg ccgtcataaa tccggtttcc aatgcggact ttaataccgc ctattaaatc 3300421 cgtctgcact tcatttctga ttctcagtga agcgactccg gctttttttg caaacacttg 3300481 tgataatggt aacatttctg catccgtcag cggtttcact gaatatacga ttgcgtcttc 3300541 tgtttgacgg gccacatttg cgagtttgat aaactcatct gtgagctcag ggacaatcgc 3300601 ggcacgatgg cggtcaatca aaagaaaaat cgtattgagt acggactgtg acaaagagcc 3300661 aaatgcattt tgaatcagct cttttttctt cgcagccggc accttcggat ggttcaacac 3300721 atcattaagc gctttttcat tttgaaatac ttgttttaca acaattagct cttcttctac 3300781 ttgattcagc tgagcggact cattggctat atcaaaaaga gctgatgcat atcgtttaga 3300841 gacagctgat ccactcatcg gctttctcct acctctttaa gatagtcctg gatcaatttc 3300901 tcttgcgctt gttcatccag ttctttttcg atcactttcg acgcaatcat gacagaaaga 3300961 gacgctactt gctcacggag agcagaaacc gcctgttcct tttccttcac gatttcagtt 3301021 cttgctgctt ctttcagacg ttcagattct gcacgtgcag cctgaataat ctcttctttt 3301081 tgcttctctc ccagtttctt tgcgttttcg ataagagttt gggattcctg tcttgcttct 3301141 tttaaaagaa cgcgctgctc ttcaatcagc tgctgcgctt ctttattttt ttcttcagca 3301201 gacgtaattt ctccagcgat gtggtcttca cgctgtttca ttatgtttaa tagcggccct 3301261 aaagcgtatt tcttcagaag cgctaataag attaacatag ctaacagttg gaacaggata 3301321 tctccgccgt taaacgacaa tcctagttca agtggtaatt gagacatcta ctacggcaac 3301381 tcccttctgc aggtttttct ttgctgatcc agcagccgca cttgtctctt ttcagccggc 3301441 aaggcgggat gcttatcaga cataaagcaa tggcgaaggt tctcttggaa tgatcttcgc 3301501 catttttagt tcatataagg cttttatgct tagccaaaga acgctaagaa tgcgataacg 3301561 acagcgataa taggaagggc ttcaactaat gcgataccca tgaacataag agttctcagt 3301621 tctttacctg cttccggctg acgggcaatc ccctctaccg tacgtgaaac aatcaaaccg 3301681 ttaccaatac ctgcaccaag tgcgcctaaa ccaattgcaa tcgcagctgc tattaaattc 3301741 atgaaaaagt tcctccttta aaatgttatc cgtttggata taatgtttta atgatcatga 3301801 ctgattttat gagacatgta caccatcgtc agcattgtaa agataaatgc ctggatagca 3301861 ccaataaata aactgaatgc ttgccatgcc agcatcggca gaatggcacc gattgtaccg 3301921 acaagaccga gagccacgct ttgcgaataa tggcttgttg ctaatcccgc aagcaggccg 3301981 agaagaatct caccggcgaa gatgttacca tacagccgca aacctagagt cagcgtattc 3302041 gcaaactctt cgatgatttt catcgggagc atgaatggaa caggtcttaa atagtctttg 3302101 gaatattcct tgagcccttt catcttcaca ccatagtagt gggttaaagc aacaaccatc 3302161 acggctagcg ttaatgtaat ggcaggatcg gctgtcggag acttccacca gagctcatgt 3302221 ccgattgtaa tagagaacgg cagccccagc atattcgaca caaatatgta catcagcaat 3302281 gtgacaccaa gtgccaagaa gttagcccct gtttttaaat ccattgtact gccaataata 3302341 ttgcggacga aatcaacaat ccattccata aagttctggg cttttccggg acggatcgaa 3302401 agcgttcttg tcgtcaatat agcaatcaat aaaacaatca cactcgccac agtaatcatc 3302461 agaatgtttg tcagattaaa agtaagacct agaaattcta tagttctgta accatgattc 3302521 aaagggtttt cacctctctt ccattgatga acgtttaagc tggataaagg aatctatcat 3302581 aatgacaggg tatattgtca ttaatccaat aactgtactt gccatatgaa agtattcggg 3302641 atttttatag gcaacagcca cagcaagaat cgcattgcac caccgcgctg cgctcccgag 3302701 agatcgtatg gactttcctt tctctacagc tctgtcaaaa gcattcattc ttctgacgag 3302761 cagtaaaaaa ttaaacaaac tgaaaacagt tcccagaata aggcctaaaa aaacggtttt 3302821 atacgctgtt aaaccataac ccagtacata cactgccaaa atgaacaata aatatttgcg 3302881 ttgtctgcta aatgtaagct tgggatcgtc catcaattat ctgtctcctg atgaaaaaat 3302941 aatgtatagc ttggatacgg caaaaatcag cggttaaccc ttagtagaag accttttttg 3303001 accggcaaaa cgggcctgtt cgaaaaaatc attcatccgc aagccttgca gggatgctgt 3303061 ttcattcgct taaataaatc ctcataatac gggtttgctg agaggattta cattgaggat 3303121 gaggactata atgaaagcta tgaaaacctt ctcataatac cctcgtttag catacaatag 3303181 cccctaacat gtgtcaatct gtttaaagtt aaaaaacttt ttatacttta cgtctccaca 3303241 gaatgttcac attttcacct ataattgtat acagattcac cgaatagcaa aaaactggat 3303301 aaaaaaatga aacccccttt tggggatttc attttttatt ttgttccaaa catgcggtca 3303361 cccgcatctc cgagacctgg aacaatatat cctttttcat ttaatttttc atctagcgcc 3303421 gcaatgtaaa tatcaacgtc cgaatgatgc ttctgcaatt cttccacacc ctccggcgct 3303481 gctacaagac acatgaaacg gatatttttc gcaccgcgtt ttttaaggct gtgaatggct 3303541 tcaactgcgg aaccgcctgt agcgagcatc gggtcaacca cgatgaattc acgctcttcc 3303601 acatcagaag gaagcttgac atagtattcc acgggtttta aggtttctgg atcacggtaa 3303661 aggccgacat gtcccacttt tgccgcagga atcagcttta aaatgccgtc aaccattccc 3303721 aatcctgctc tgaggatagg aaccactccg agttttttcc ctgagatgac tttcgatttc 3303781 gcagcctgaa ccggtgtatt gatatccact tcttccagag gaagatcgcg ggtaatttca 3303841 aatgccatga gtgtagccac ttcatctact aactctctaa aatccttcgt acctgtattt 3303901 tcattccgta tatatgtcag cttgtgctga attaaaggat gatcaaatac ataaaccttt 3303961 cccatactgt gtttcagctc cttttttatt gtcccatcaa caattacaca cttctattga 3304021 ttctacaaaa aaagacattg agtttcaaga acatcgtcaa aaaacccgcc gggcataagc 3304081 ccaagcgggt tttaggatct taataatcta attctttata taaaggaaat ttatcagtca 3304141 gagcagctac acgctgtctt gcttcttcaa gttttccttc atcttcgtgg tttttcaatg 3304201 caagcgcaat gatagcaccg acttcttcta atgcgtctcc gtcaaaaccg cggctggtta 3304261 cagcagctgt accaagacgg atgccgcttg ttacgaaagg tttttcagga tcatatggaa 3304321 tcgcgttttt gttagacgta ataccaattt catcaagtac atgctccgca accttaccag 3304381 tcagtccgag cgaacgaagg tcaacaagga taaggtggtt gtctgttccg cctgaaacga 3304441 gctggatgcc ctctttcgtt aaggcttcag ccagacgttt cgcgtttgaa atgacgtttt 3304501 gtgcatatgt tttgaaatcg tcctgcaata cttcaccgaa tgaaacagct tttgcggcaa 3304561 taacgtgcat cagagggccg ccttgaattc cagggaagat cgatttatca attttcttgc 3304621 caaactcttc acggcaaagg atcataccgc cgcgaggacc gcgaagtgtt ttatgtgttg 3304681 ttgttgtaac gaaatcagcg taaggaaccg ggtttggatg aaggcctgcc gcaacaagtc 3304741 ctgcgatatg tgccatatcc accatgaagt aagcgccgac ttcatcagca atttcacgga 3304801 atttcttaaa gtcgattgta cgaggatacg cacttgctcc tgctacgata agcttcggtt 3304861 tatgagcgag ggctttttca cgcacgtcat cgtaatcaat atattgagtt tctttatcta 3304921 cgccgtactc aacaaagtta tattgaacac cgctgaagtt gactgggctt ccgtgtgtta 3304981 aatggccgcc gtgggagagg ttcatcccaa gtacagtatc gccttgctcc aaaatcgtga 3305041 agtacactgc catgtttgct tgtgcgcctg aatgaggctg aacgtttaca tgctccgctc 3305101 caaagatttc cttcgcgcgg tcacgggcga tatcttcaac gacatcgacg tgctcgcatc 3305161 cgccgtagta gcgtttgccc ggatatcctt ctgcgtactt atttgtcaaa acagatcctt 3305221 gtgcttccat aaccgcttca cttacaaagt tctcagaagc aatcaattcg atcttagtct 3305281 gttggcgttc acgctcattt ttaatggcgt taaacacttg ttcgtcttgc gcaggtaaat 3305341 gtttcatcag cgagatcctc tcctatccgt atcctgttct ttgtttttac catcactatt 3305401 gtacatggtt tttaaggccg atgtaaaaga ttatttttaa aaaatctaaa tttttattgg 3305461 taaaaacgaa tattaataac ttaaatttaa tttaaagttc ggaatttatt tcactatctt 3305521 aaaataaaag aaaagactgg ctatgcagtc ctttcattcg cactcataaa ccgcccgcac 3305581 tccgccgatt agtttcggcc gtgtacgcgc caatgtcaca tgagctgaac cgaggctgtt 3305641 ttgagagaca cgcacaggga cagccaccgg tttcagatgc atgccgataa acgtatcgcc 3305701 tatatcaatt ccggcgtcag cctgaatggt ttcaacaaga acaggagact tcatctgctt 3305761 aaacgcataa gacgccatcg ctccgcccgc ttttggaacg ggcacggcag aaacggttgg 3305821 aagcctgaac agcttggctg tttctgcttc gacgacaagc gctctgttta aatgctcgca 3305881 gcattgaaac gccagatgga ttcccgtttt ttcccggagc tcagcaagtc cgctgtagat 3305941 gctttcagcg atatctacac tgcccgatgt gccgatccgg ctgccggcca cttcgctcgt 3306001 gctgcatcca aggacgaaga gctgatcttg tttcaattcc gcttggtcct gaaactcaga 3306061 cagcatcgtc ttccacgttt gtttcaactc attcattaaa cagcacccct acaggttttt 3306121 ctcttcataa tcggagattt ttccaatacg cgtttggtgt cttcccccgg taaactcagt 3306181 agtcagccag atttttgcga tttcccgagc caaaccaggt ccgatcaccc gttcacccat 3306241 cgcaaggatg tttgtgtcat tatgctccct cgtcgccttc gcgctgaagg tatcgtgcgc 3306301 cagcgcgcag cgaatccctt ttactttatt agcggaaatg ctcatgccga tgcctgtccc 3306361 gcaaattaaa atgcctctgt caacttcgcc gctaaccact ttttcggcca ccggaaaagc 3306421 ataatccgga taatcgacag agccgctgcc gcagtcacag cccatatcaa tatattcaat 3306481 ttgcaattcg tccattaact ctttgatttc atttcgaatg tgaacgccgc catgatccga 3306541 tgcaatggct actttcatct gcttttcctc ccagcgtgtg tgatgcggcc cgcccgcttt 3306601 attgaccgcg cagcctgtcc gctctttgat tcacaccata tgatgtgctt ttcactatat 3306661 tctactcctt cacgcaggat ttgcaaatga cctgtttgca gattttctga caacttatct 3306721 acggtctttt ttcagctgtt ttgccagctg ccgaagaagc tcttcaagct catctcgcgt 3306781 ttgtttatag atgtcaattg agccgccgaa cggatcgagg acatcaccat ggctgcctgt 3306841 gacatattct tttaacgtaa acactttatc acgataacgt ccaaattggc tggcaatgat 3306901 ctgtttgtgc tgatgggtca tagccagaac caaatcagcc gattccataa gttcttcagt 3306961 taatggagaa gacacatgat taagggcaat gtgtttttca aacagcgctt cgactgcatg 3307021 aggcgtcgct ttcccattag gtgaagcaaa cacgcctgcc gagcggacat tgacattcag 3307081 cccttccctt tctgcaattg atttaaaaag cgcctcagcc attgggctgc ggcacgtatt 3307141 tccagtacag acaaaaataa tatccatgtc agtcacccct tatttttctc tattatatat 3307201 gaagaaaaaa gaaacggcga cttcgtttct tttattggta tattaaattg gcaaaagcag 3307261 ctttaatcca aacacgatta atatgatgcc cccgagcgct tcgctgtatg tgccaagcca 3307321 tgactgcact tgttttccga ccagcaggcc cagccatgtc aacatcatgc tgaacagccc 3307381 gaacagggta attgtgagga gcggatgcga gccgtatatc cccaagctca agccgacgga 3307441 aaagctgtca aggctgacgc cgatggcaaa cagcaataag cccggccctg ccggtgacat 3307501 gaatcgttct tctgactgtt taaaagaggc cataagcatt tgaaccccaa gaacaaaaag 3307561 cagcgcccca ccgatataaa ccgctaacac gccgaggagc cctgacagca tgttaccggc 3307621 cgccatccct gcgagaggca tgatgacgtg aaagaggccg atgatgaaac caatatagaa 3307681 tatctgcttc tttctaagtt tgaccatgcc cattccaagg ccgacagaaa aagcatccat 3307741 ccctaaagca aacgccatga tgcttaatgt aatcagttcg cctataaaca aatccgacat 3307801 acataaataa cccccttgga cacgccccgc ttttttagcc tatgcgtgtc caaaaagggt 3307861 tagaacatct gactgctttc agcgaatcac tcttcctccg gcggctttca tcagcctgtt 3307921 cataatagca agaccgacac ctgtatccgg aaaggattcc gctataatga aatccacctt 3307981 attctcatca aagctgcgca aagcatcata cagccctgcc gcaacagtct caagctgagc 3308041 ccgtcttccg cagctcttca cataatcagc ggaataaacg cccgcttttt cttctgtcgt 3308101 caggacaccg acccgtcttc caccctgttg atattcttga atgaggtgct gaatgcgctc 3308161 tgggctgcct tcgcaaatgg caagaggcgc tgtcggcgca taatgtgtat atttcatccc 3308221 tggagaaatc ggcttctcgt tttggtcgct gagcccttta tccacatgga tcggcccgat 3308281 caccgcttca atttgttcct tcgtaatgcc gccaggacgc aagagaacag ggatgtcgtc 3308341 cgcacatgaa agcacagttg attcgacccc gattccggta gggcctccat ccacaatacc 3308401 ggctatgcgg ccatccaagt cgtgagccac atgctccgct tttgtgggac ttggcttgcc 3308461 tgatagattg gcgctcggtg ctgcaatcgg cagtcccgat tcgcgaatca atgcaagggc 3308521 aagcggatga tccggcattc taatggcaac cgtttcaaga cctgccgtta cacgaggtga 3308581 aagcgcatca ggtttgcaag gcagaatgag cgtaagtgct cccggccaaa accgtttcat 3308641 caatgttttc gccttttccg gcgccgggcc cgttaaatcc tcaagctggc tgatatccgc 3308701 aatgtggaca atcaggggat tatcgctcgg ccgccctttc gcctcatata tttttttgac 3308761 ggcatccgta ttttttgcgt ttgcgcctag gccatatact gtttctgtcg gaaaggcaac 3308821 gacctcattt tctcggagca aagcggctgc ttgtgcaatt tgtggatcat ttgtggataa 3308881 ctcgtcagtt acatccacaa accatctttt cgttttcatt tctgaccaaa ctccttattc 3308941 acaacaataa aacgattgtt ttacgcgtgt aatccttttg aaagtataaa agatgtcctg 3309001 taataaaaca agcgttatcc acaaattgtg gacaacgcta ataaagaagt ggataagtat 3309061 gtgtataaac tgcacttatc cagacgcttt tttcatcaaa acggctcctt ctgtttgccg 3309121 cgattcacag aagtgatcag aagaaaacag ctcctccggt acactctcag ctctttcaaa 3309181 acccatggcc gtcagaaagt ccgcagagga atgctgattt gctactaggt acacggtttt 3309241 gatctgatgc ttttcgcaca gcacctccat gctttgaaaa agcgtgacga tgtggccttg 3309301 gtgaagcttg tccgatatga caagtgatcg cagcagcccc tggtcacagc ttattttttc 3309361 aataccgagg catccggcaa tgtttttctc actgtcctcc agcataagaa attgagtgaa 3309421 gccttctttc acgccttcat agctggtttt tgcctgtttt aaaaatgcct cgagcacatc 3309481 tccgtctttt tcccttgcca cccgcagttg ataaaacatc cgttcacccc gtttttgcgt 3309541 tctttcttcc aatctatgag gcaaatctat ttttagacca gatgattagg aaaaaaggtc 3309601 ggaaatccat tcgactaaaa agaatttcac ttctgtgccg tcttcttttt cttcgttctc 3309661 ttcttttttg gctttttccg ctttagcggt tacgtcctca agcacttttt cagtctgctt 3309721 ttttgaggct tctttatctt cttgttcttt gacggcttcc ccgttagaaa aatcaagaaa 3309781 gcagaggggc gggaacagca cacaccacca gttggcgccg tctccgtttc caagcgtaat 3309841 caaaatcgct tcatactcac cagcgggata taccatgttg ccgtaaagct ttgtcggaaa 3309901 cgagattttg tcaaaatcaa cggatatcga ctgattcgct ccttctttct ccattgtttc 3309961 ctttgcaatt gctttgattt caggcagctt tgaacgaatc acgcgacgcg cttcttcaat 3310021 agaagtaata tcctttaccc aagttgtgat ttctttattc accgcgtctc ttatatgacg 3310081 ttttaattgc tggtcttgat cactatcgct gtttgccagt attctcaaac gaatcgcctg 3310141 atcaggtatg accaccggct gattttccga tttttgtgcc gtctcttctt ttgccagccc 3310201 tacgagcgct ccggataata aaagaaagat atatatacaa atgattactg tttttttcat 3310261 cggtccccac cgttcctctc cgtgctttgt ttctagccct attatggaca aggagagcct 3310321 gggataaacg tgcagggtga aaaaaatcta gcaagctgtt aatcttattt atggtacgat 3310381 agtgttttag gaggtttaag atgaaataca attatacagt gctgttatca gcattcacga 3310441 tgtccgttct ttattcagta atttatattc attcatttat cattgccgct ctcatcacaa 3310501 tggcatttta ttttctgttt ccttatttga tcttcgcact gccgcttcaa atcatgatga 3310561 ataaaaagcc gaaacgtttc agccctttgt atctgctgta ttaccttgcc gctgctttta 3310621 ttgccaacgc gatcattttc ggcatgcttc agccttcggg acaatctctg tttcaaaata 3310681 cagcctttta tcttttcgct gtattaacag ctcttatcta ttggatatgg gattctgttt 3310741 tactgcaaaa aaaggaagcc taagaggctt ccttttttat taaaacaaaa tcgtcagtaa 3310801 ataacataga atggaaggta tcgccgcaac aaagaaagcg gccgccattt tcatgcgaga 3310861 tgtacggcct tctttggttt ctgaatggta gtttgcccgc tgatcgcttc cgcttacagc 3310921 caaacccgat gtaatgatcg cgagccccac taaaacgaga gacgcaacgc caaaaatcgc 3310981 ttcatatgaa agagcctgcg gaaaaatggt gccaatcatg ctctcaatcg caatgagcag 3311041 gattcctgct gtcagggcct ttttcatgtt tacatcccct ttgctggtgt taaacagctt 3311101 gatccattca ctcgccagca agctgcttat ttatttttat gaatcagagc gcatatggtt 3311161 ctgtcttttc cattaatatc tttcagcact tccacttccg cccccttaaa cgccttgagg 3311221 atcaggtctt tgaccgccgc tccctgtttc cagccgattt caaaaacgac aaatacttta 3311281 tccttcataa caagcggaat gtcttccata aaccgcttat aaaatttcag cccgtctccg 3311341 ccatcggtga gtgcgtgcag cggctcatga aaacggacaa tttccgataa atcagccatt 3311401 tcttcctctg aaatatatgg cgggtttgag acaatgatat ccgctttttt tcccgcctta 3311461 ataaaaggct caagcagatc gccctgataa aagcgcacat tcgctccgag tttttctgca 3311521 ttggcagagg cgacttgcag cgcctctttc gaaatatcga ccgccgacac agaaaagctt 3311581 tggttttcaa gcgcaagcgt gacggctatt gcgccgctcc ctgtaccaac gtcaacaact 3311641 tcgagcttgc cgtcttcaga aaaaacactc cgatattttt caagcaaatg aaagacaact 3311701 tcttcagttt ccggccgcgg gatcagcaca tcatcattca ccataaattc ccgtccataa 3311761 aaaaactctt ttcctataat gtattgaacc ggcacgccct ctttatgcat ctcaacgtga 3311821 cgcttaaagc gatacagttc gtcttcacca atcggttcct gtaagcttgc gagcagcttg 3311881 cttctctcca ttccggtatc ataaagcaat aggagctcgg ccgcattttc ttctcttccc 3311941 gcttcggtta aataagaaga agcccatttc agggcttcga atatcgtctt catcttaacc 3312001 ttccgactgc tgaagcttgc ttgcctgatc ttcaacaatc agcgcttcaa ccacttcgtc 3312061 aagttttcct tcaagaatct gatcaagctt ttgaatcgtc aaaccgattc tgtgatccgt 3312121 cacacggttt tgcgggaagt tgtatgtgcg gatacgttca gagcggtcac cagatccgac 3312181 tgctgatttc cgtgtttgat catattcagc ctgggcttcc tgctgaaatt tatcatagat 3312241 tctggcacgg agaaccttca ttgctttttc tttgttctta atttgagatt tttcatcctg 3312301 gcatgataca acaacacctg tcggcaagtg agtcagacga accgcagaca ttgttgtgtt 3312361 aacgctttgt ccgcccggtc cgcttgaagc aaatgtatcg acacggatat ccttctcatg 3312421 gatgtcgacc tctacctctt ctgcctcagg aagacatgcc actgttgcag tggatgtatg 3312481 gatgcgtccg cctgattctg tttccggaac acgctgtacg cggtgggcgc cgttttcata 3312541 tttgagttta gaatacgcgc cgcttcctgt aatcataaag atgatctctt tgtagccgcc 3312601 cgttccggtt acattcgctt ccatgacctc tgttttccag ccctgaagct cagcataacg 3312661 ggaatacatt ctgtacagat tgcccgcgaa taaagcggct tcctcgcctc ccgcagcccc 3312721 gcggatctcc atgataacgt ttttgtcgtc attaggatct ttcgggatca ggagcacctt 3312781 cagccgttct gacagtgttt ccgtttcctt ctgaagttca gaaatctctt ccttcaccat 3312841 gtcgcgcatc tcagcatcca gcttctcttc aagcatcgct tttgcatcag ccagctgttc 3312901 tgacgcatct ctgtattgtc tatatacgtc aactgtttct tgtatatcag attgctcttt 3312961 tgaatattct cttagctttt tcggatcgtt gactacttct ggatcgctca aaagctcatt 3313021 taatttctcg tatcgttctt caattgattt taaacggtct aacacggtct tcacctctgt 3313081 tttcctgtgc gtaacattct cattatagta tagtgattaa ccccagtcaa aagcatttca 3313141 atcccagctg gaaaagctcc ctctgctata ctggaattcg aggagggatg atgttgctga 3313201 aatccataca tcatattgca atcatatgtt cagattacga aaagtcgaaa gctttctacg 3313261 tacataagct tggttttcag gtgattcaag aaacgtaccg cgaagagcgc ggctcctata 3313321 agcttgattt gtcgcttaac ggctcgtatg tcattgagct gttctcgttt cccgatccgc 3313381 ccgaacgaca aacccggcct gaagccgcag gcctgcgcca cctcgccttt acagtcggca 3313441 gcttggataa agctgttcaa gagcttcatg aaaaaggaat cgaaacagag ccaatcagaa 3313501 cagatccgct gaccggcaag cgtttcacct tcttttttga tcctgaccag cttccattag 3313561 aactgtatga acaataacag tttttgaaga aaaaaaggag atacccactt tctttgccga 3313621 atcttttctt gttttgtcta acgggaaggg aaccgcattc tatggtcgaa tacctagctt 3313681 aaaaggaggt atgggatcat gaatacaaat atggtagcaa gtgaactcgg cgtctccgca 3313741 aagacggtgc agcggtgggt gaagcagctg aatcttccgg ccgaacgcaa tgagctcgga 3313801 cactattcgt tcacggcaga agacgtgaag gttctaaaat ccgttcaaaa acaaatctct 3313861 gaaggcacgg cgattcagga tattcatctg ccgaaaagcg ctaaaaagcg cacaggcttc 3313921 cttgtccaaa aaacaagtag cgacacagaa cgaagaatcg agcagcttga acaaaagctg 3313981 gacacccttt tacagcaaag gcaggacgaa agcgaattga tggcaaggat gtcggaactg 3314041 gaacgccagc tgaaacaaaa agccgatgaa ggtgtatctt accagctgct tcagcaccgc 3314101 agagaaatcg atgatattct tgcagatctg caatcactga cctcacaaat gaaagaattc 3314161 accgctcatt cgatccccga gactgctgct gcttctgaaa aaaccaaaac aagaaaaaaa 3314221 ccgctgctgt cactgttcaa atttcaaacc taaagcaaaa agctccctta aagggagctt 3314281 tttttgttac gcagtaagcg cgataatgat tggaagtgaa atcaatgaca gaatcgcact 3314341 gaccacaaac gcagttgcag tttcttcttc ttgtttctcg aaacgagtcg caatcatggc 3314401 tgcaacggca gaaccaggga atgcaacaag aaggattgct tttgttgttt ggtcagctgg 3314461 aagtccgata gcaagagcaa tcaggaacat taacgcaggc tgaaccgcaa cttttagtaa 3314521 cgcaataccg atagccggca tactgagttt aattttacga ataccaacgg taacaccaac 3314581 agcgaagaga gcaacaccag atgttgtgct tccaagctga tcaagcattt taacacccag 3314641 ctcaggaaga gtgaaattga aaaccagcac caagatcata ctgattaacg gagcagctgc 3314701 aagcggctca caaagaccat gcaggattga ttttcctgtc atcttccaga agctgtcgcc 3314761 actctcttcg tttttcttag aagactcacc aacagtagcg ataatgatcg cgagcggatc 3314821 aagaatcgcg ttaaccacga tacctgtgac cgcgatcgga atcgcaactt cattcgctcc 3314881 gaataagctt cccaataccg ggatacccat aaatgcgaat gtcggctgtg cagagttcaa 3314941 agaaaataca gatgagttcg ttaaatcata cttgaatata aatctgcaaa ccaaaagaat 3315001 gatgatatag aaaccaacaa tcccaataat taaagaaatc attaaaggta cttgtgataa 3315061 aaattcactt ctggaagttg tcaaaatacc agcgataaag tgagctggaa gtgcgtattt 3315121 cgttactaac gtacttaccc cttttgccga cttggcatca taacttccaa aatgtcctgc 3315181 aaaccaaccc agcacgataa caaagaagat cggcgccagg aggattaaga tatctaagat 3315241 gctcaaaata ttctcctcca aatcctatgt ccgtatactt tagctttaca aaaagctttc 3315301 cctcggacag aaaaatttac tcgctaatta tttcgcgatg acttttttgt attcaggtgt 3315361 ccacattgca tcaagtaccg cttgtttcac atcttcaggc tgacgatttg ccacgccgtc 3315421 tttaattgct gcttcagcaa cggcaatcgc aacttggata gaaacctctt gaagcttatc 3315481 aatgcttgga agcaatcctg ctccaggtgt ttcaagatca accatttcag caatcgcatc 3315541 agcagttgca gcaaacatag caggtgtaat gatacgcgct tcagctacaa ttgaaccaag 3315601 tccaagacca gggaacgcga atgcgttgtt agattgtccg atttcataag aaacaccgtt 3315661 gtattctaca ttgtcaaatg ggcttcctgt tgcaataagc acttttccgt cagtccattt 3315721 gaacagatct tcaggaacag cttcagcaag gtgagtcggg ttagacatcg gcatgataac 3315781 cggacggtct acgtgagatg ccatttcttt tacaatttcc tctgtgaatg cacctgaaac 3315841 ccctgaagta ccaatcaaga ttgttggttt cgcttgacga acaacttcat cgaatggaat 3315901 ttgacctttt tcatcgcgct tccagtcttt cacttcatcc gcattgcgaa ggtaaggttt 3315961 ttggaaatca aggatgcctt cgatgtcttc agtcagcaag cctctgtaat caagtgtgta 3316021 gaaacgtttg ttagcttctt cttcagataa tccggctagc accattgtgt cacggatttg 3316081 gtcagcaata ccgataccag cagaaccagc accgaagata acaacacgct gatctttaat 3316141 agaagcgccg gttttcttca tagcggcaag cacacctgca agtgtaatcg cgccagtacc 3316201 ttgaatatca tcattaaatg tcaggatttc atgattgtat tttttcatga tgttgcgtgc 3316261 atttttgttg ccaaggtctt cccagtgaag aagcgcttta gggaagaatt tcaatgcagc 3316321 ttttacataa gcgtcaatga aagcttcgta gcgttcacct tgaacacgtt catgcttgtt 3316381 accaatatat aaaggatcgt ttagaagttt ttcgttgttc gtaccgacat caagcacaac 3316441 cgggataaca cggctagggt caataccagc tgcagcagtg tagacagcca atttaccgat 3316501 tgcaatatta ataccgccta caccccagtc accgataccg agaatgcttt cggagtcagt 3316561 agcaacgata agatcaatat cgcctgctgt cgcatgaagg ttttcaaacg ctttttcaat 3316621 accgtcaatg ttatcgattg acaagtagat tccttgaggt cttctatatt catggctgta 3316681 ttcctgaatc gcttcaccaa ctgttggcgt gtacacaaca ggaagcattt cgcgaagatg 3316741 gtttttcagc aatttataga aaagaacttc gttacggttt gcaagatcac ttaagtaaac 3316801 attttgacga aggcggtcag gctgcgcttg gaattgctcg tacgcgcgtt gtgcttgttg 3316861 atcaagagaa agtacagttg gcggcagaag cccttctaag ccgagttctt gtctttcttc 3316921 tagtgaaaaa gcaacgcctt tatttaaagt aggaatagat aaaacttctt ttcctctaag 3316981 agttgtttct aagtggcctt ctttcgtttt ttttatgtta ttcaagcaaa tctccttctt 3317041 tcttgaaata gttaaccaag ttaagtaata acccatctaa aatatgaccg atcatgatct 3317101 ttatgcgact ttgtgacaat tattcgaaca atgtctcaaa actatttaca ttacgtaagc 3317161 tattgtatgc ctgtcaaaat caaaattcaa gagaagaaaa ttacttaatt ttttaatata 3317221 cttatttaaa ttttttaatt gaatattatc agaatataaa aaaaacaccg gtgtttttag 3317281 ccggtgcatt ctatctttat acccatgttt tggactattt tttagattta cctgggactt 3317341 cgtgatgatg tctgcatctt gcttcatatg attcagctgc accaaccaaa atgaccggat 3317401 catcgtaaga agcaggtttg ccgtcaatga ggcgctgtgt tctgctcgcc ggtgatccgc 3317461 aaacagaaca gacggcttgc agctttgtca cactttccgc aatcgccatg atattcggga 3317521 cgacaccgaa cggctctccc ctaaaatcca tatcaaggcc tgctgctatc acacggtagc 3317581 ctttatcggc aagagatgat aaaacctcaa caatttcctg atcaaaaaac tgcacttcat 3317641 caaccgcaac cacatctgta ctttcactga tgtgatccca aatgtccgca gcagacgaaa 3317701 tggcatagct cgtcatcgat gttccattat gggagacaac agcagcttcg ctgtatcggt 3317761 tatcaattac aggcttaaat accctgactt cctgcttggc ataagttgct ctcttcactc 3317821 ttctgatcag ctcttcagat ttccccgaga acatgctgcc gcaaatcagc tcaagccacc 3317881 cgctttgttt cattatgtac ataggcttcg ctcccctctc tctgccagct gtgttttaga 3317941 caatataaaa aacaggcaag actgctgctt gcctgttgag aaatctatta ttacttaaga 3318001 ccgtattttt tgttaaagcg atcaacacga ccatcagcag aagcgaattt ttgacggcca 3318061 gtgtagaatg ggtggcattc agagcaaatc tcaacgcgta cctcttcttt tactgagcct 3318121 gtttcaaatt catttccgca agcgcattta actgttgctt ttttgaaatt aggatgaatt 3318181 cctgctttca ttgtatccat ctccttccgc cctgaatccc gtgtggaaac agagttatta 3318241 tttcggagca ttgtccgaaa cgcatatgag aaaattatat cagtgattta cttcttttgc 3318301 aaatacaatt taccttcttg cagatgatag atttgcctgt ttccattctt gattgagaat 3318361 atcgaaaaat tcctggtttg ttttggtttt tttcattttt ctcatgaact tttctgcgaa 3318421 atcaggtgaa tcagacatcg ttttgcggat agaccataaa cgatcaagat gctctttagg 3318481 cacaagcagc tcttctttgc gcgttcctga acggcggata tcgatggcag ggaagatgcg 3318541 gcgctcggca agagagcggt caagatggag ctccatgttg cctgttccct tgaattcttc 3318601 ataaatgaca tcatccatac gtgaacctgt atcgaccaga gccgtagcaa ggatggttaa 3318661 gctgccgccc tcttcgatat ttctcgcagc cccaaagaag cgtttcggac ggtggaacgc 3318721 cgctgggtca atccccccgg aaagcgttct tccacttggc ggaatcacta agttgtaggc 3318781 gcgggcaaga cgtgtgatgc tgtccatcag gataatgacg tcttttttgt gttccacgag 3318841 acgcatcgca cgttcaagca caagctcggc cactttgata tggttttccg gcacttcatc 3318901 aaacgttgag ctgacgacat ccccagctac agagcgctcg atatcggtta cttcctcagg 3318961 tctttcgtca attaaaagca cgatcagctc tgcttcaggc tggttcgctg taatgctgtt 3319021 ggcaatttcc ttcagcaaca tcgtttttcc ggctttcggc ggcgcaacaa tcaatccgcg 3319081 ctgcccaaat ccaaccggcg ccatcatgtc cataattctt gtagacaaga agttcggctt 3319141 tgtttcaagc accatttgac gatccggata aagtggcgta agagccggga aatgcacacg 3319201 ctcttttgca gattcgggat catccccatt tactgcttca acgtgcaaaa gtccatagta 3319261 acgctcattt tcttttggcg ggcgaacctt gccagatact ttgtctccgt tccgcaaatc 3319321 gaaacggcgg atttgtgaag ctgagatgta aatgtcttct gagcttggag agtagttgat 3319381 cggtctcagg aatccgaaac cttcagactg gatgatctcg agaacgcctt ccataaacag 3319441 cagatcttcc tgttctgcat tcgctttcag aatggcgaaa atgagttctt tttttgtcag 3319501 tttgctgtaa taggagattt tataatgtct tgcaagttca taaagctctt tcaatttcat 3319561 attttccaaa gaggaaatag atacgtcttt cataaaaaca ccacgctttt catagtcaat 3319621 atcttactct gaacatgtca tctgctgctt ttgcacaaca tccgccaaag cacattcttt 3319681 ttttaacata aaggaacttc tatcggtaac acttccaccc atgatcggcg cttttgttaa 3319741 aaggattgtc ttaatgagtt ttgaaggaag cgaggacaaa aacatgagaa gatcaatact 3319801 tatatcgtct gtatgcggta gaaattgaaa ctttcctagt gcttaaaaga aggtattacg 3319861 cagtaaaatt cgcagcactc tttattttta ccttatttca aaaaattatt caactgaaat 3319921 aaggttttga cacggaattg atagagttga cgcttttctg caaaagttaa agcgggctca 3319981 cacccgcttt ttctgtttgt tatggacgga ttacaagatt tggtttcttt ttcaagctgt 3320041 gtctgccgtc aacgaaacga acagtgcccg attttgcacg gataactaag ctttcagttg 3320101 taccgacaga gcctttgaat tgaactcctt ttaacagctc gccgtcagta acccctgtag 3320161 ctgcaaaaat cgcgtcatca cccttcacaa ggtcttccat gcgaagcact ttgcttaaat 3320221 caaggcccat tttgtgacag cgagtgattt cttcttcgct ttgcggaaga agtttaccaa 3320281 tgatttctcc gccgagtgct tttagcgcaa cagcggaaag cacaccctca ggagcgccgc 3320341 ctgatccgaa caggatatca acgcccgtgt ggtcgaaagc cgtgttgatg gcgcctgcga 3320401 catcgccgtc attgatcaat ttgattctgg cgccggcctc acgaagctcg gaaatgattt 3320461 ttgcgtgtct ttcacggttt aaaattgtgg caacgacgtc ctcaacgtcc ttgtttttcg 3320521 cttttgccac cgctttaagg ttgtcaatga caggtgcttc gatgtcaatg cagcccaccg 3320581 cttccggacc gactgcgatt ttttgcatat acatgtcagg agcattcaga agcgtgccat 3320641 ggtctgcgac cgcgataacc gtcagcgcgt tccagccgcc gcttgctaag atgtttgtgc 3320701 cttcaagagg gtcaactgcg acatcaacgc gagggccgta cccgtttccg agtttttccc 3320761 cgatatacag cattggcgct tcgtccattt ccccttcacc gattacaacg gtccctttca 3320821 tcggcactgt atcaaaaacg tctctcattg cacttgttgc cgcttcatca gcctcatctt 3320881 tttttccccg gcccatccat cttgctgatg ccaatgccgc agcttctgtc acacgtacca 3320941 attccattga taaacttctt tccatttcaa cacgatctcc tctcacaaga aaccattatg 3321001 aattttgaag ctgttctatt tcttcgtcag tcattctttc acgccaaatt gtcgctccaa 3321061 gcccctcaag cttcttctca aggctgctgt atcctcggtc aatatgctcc agtcccgtaa 3321121 tttccgtgac gccatcagcc atcagtccgg ctaccaccaa gcaggctccg gcacgcagat 3321181 cactcgcctt cacttttgcg ccttgaagct cgacaggacc tgtgatgatg gcagatctgc 3321241 cttctacttt catattggca cccattcgtc tcagctcatc aatgtgcttg aatcttgccg 3321301 agtagatggt gtctgtgacg acactcgtcc ctttcgccct tgtcaggagc gccgtcatcg 3321361 gctgctgtaa atcagtcgga aaccccgggt atacgagggt tttgacgtca accggcttta 3321421 agttcttctg cccgccgaca atgaggagct ggtcgtcgct tgtttcgata tgatagccca 3321481 tttctctcag ctttgccgtt aacgactcaa gatgagtagg gatgacgtta tcgataatga 3321541 cttccttgcc cattgcagcc cctgcaatca taaatgtccc ggcttcaatt ctgtccggaa 3321601 tgatcgtatg cttgcagccg tgcagttcct tcacgccgtc gattcgaatc acattggtgc 3321661 ccgcaccttt gattttggcg cccatgctgg taagcaatgt cgcgacgtca atgatctcag 3321721 gctccttggc agcgttttcg atgatcgttt tcccttctgc caaaacagcg gcgagcataa 3321781 tgttaatcgt tgccccaacg cttacgacat ctaaataaat ccgtgcgcct ctcagccttt 3321841 cagctcgcaa ataaatggcg ccttgttcat tggttacttc agctccgagt gcttcaaagc 3321901 ctttgatatg ctgatcaatc ggacggggcc ctaagtgaca gccgccaggc aatccaatga 3321961 ccgcctgctt gaagcggccg agcatcgccc ccattaaata atatgacgcg cgaagctttt 3322021 ttactttccc gttaggaagc ggcatgctga tcatcgacgt agggtcaaca accatttccc 3322081 cattctcaaa atgcacgttg ccgccgattt cctttaacag gtcacgcagc gtttcaatat 3322141 ctgaaatctc tggaagccct tcaattgtca cctcggaatt tgccaaaatg gttgcaggta 3322201 ttaacgcaac agcgctgttt ttagcgccgc tgatatgtac tgtaccgttt aacgagtcac 3322261 cgccggcaat attcaacttt tccatgatag tctccttcca taagaagata gctgcggagc 3322321 taaataaaat gtcattttat tctgtctctg caaataaagc tcatgtccaa aatctagcca 3322381 attcgaagag aaagaataca acacattgta aaatatcagg aagaaaatag cgaagctttg 3322441 gggggtacag gtttcaaaag atgcacagag acccgccggc tcgagagaca tcgtcgtcat 3322501 ccggcaaaag cagtacgcat acccttcatt ccgatatcag cttctgcagc ccaatgattc 3322561 cttctctgta aagcggcgtc agcatctgaa gatccgctgt atcaggtcgg tgaaatacaa 3322621 aggccgcggc aaacaggcat aaagctgttt gccgcccctt tcattatttg ttccagtctg 3322681 ccaggaattg ttcgattcct ttgtctgtta acgggtgttt agtgagcgca tgaatgactt 3322741 tcagcggcat tgtgccgata tgagcccctc taagagcagc ttctgtcacg tgctgcggat 3322801 ggcggattga cgctgcaatg atttgcgtgt caaggccgtg aatgtcaaaa atctgtttaa 3322861 cttctgaaat caggtcaagc ccgttgtggc cgatgtcatc taaacgtccc aggaatggag 3322921 atacatatgt tgcccccgct ctggcagcaa gaagcgcctg gttggcattg aagatcaatg 3322981 taacgtttgt tttgatgcct aagtcagtaa gtgctcttac cgcttttaaa ccgtcagacg 3323041 tcattgggat tttcaccgta atgttcggag cgatcttcgc cagttctttt ccttcctcga 3323101 tcatttcctc agctttcaaa gaaataacct ctgcgcttac agaccctttc acgacgtctg 3323161 tgatctcgcg aagacggtcg tggaatgata cgttagcttc ctttgctact aaactaggat 3323221 tcgtcgttac accggcgaga attcctaatt cattcgcttc tctaatttca tcgatattgg 3323281 ctgtatcaac aaagaataac attttcaaaa agcctccctg attaagaaat tttctgaact 3323341 gcgaatatga ttgcgctttc taaagataga cggaaaaccg cctgtcaagc tgtcaggcgg 3323401 ctataaaaag ttccaattga attaagcttg gtttgaagaa ccaaattcac gcattttacc 3323461 gataactgtt tctttgatcg cttcacgagc tggtccaagg tatttacgtg gatcgtactc 3323521 gtcaggctta gctgccaatg tttcgcgaac agcttttgca gaagaaattt ggttttcagt 3323581 attcacgttg attttagctg taccaagtga aattgatttt ttgatgtcag cagtcggaat 3323641 tccagtaccg ccgtgaagaa ctagcggaag gccagttgat tttccgatct cttccatttc 3323701 tttgaagcca aggtttggct cacctttgta agggccgtga acagaaccta atgcaggtgc 3323761 aaggcagtcg atgccagtgc gctcaacaag ctcttggcac tctttaggat cagcgtagat 3323821 tacgccttca gcgataacgt catcttcttg tccgcctact gttccaagct cagcttctac 3323881 agatactccg tggaaatgag caagctcaac aactttagca gttgttgcta cgttttcttc 3323941 aaatggatgg tgagaagcgt cgatcattac agatgtgaaa cctgcatgaa tcgctttcgc 3324001 acaagattca aagcttgaac cgtggtctaa gtgaatcgca acaggaactg tcactttgta 3324061 ctcttccata agtgctttta ccatagcaac gactgttttg aagccgccca tgtagcgtcc 3324121 cgcaccttcg gaaacaccaa ggatcactgg agatttttct tcttcagctg cttgtaaaat 3324181 cgcttgagta aactcaaggt tgtttaagtt aaattgtcct acagcgtacc ctttttcttt 3324241 agctgtattc aacatttccg tcatagaaac taaaggcatg tcgaatgtcc tccttatgta 3324301 gcctgattgt cttctagcga aaaaagcttt ccaccctagc atgacccata tattgctgtc 3324361 atatgtaaat actcagatcg ctttttctcc ataactagga taccaacttt tcgacaaatc 3324421 ggcaacataa tgacatgatt catttgtttc ttctttttgt cagttagact tcaggggcag 3324481 atattttttg acggcgtctc tgatttcgtc gatgtcaaac ggcttggcaa agtgcgtcag 3324541 agcgcccaat tccttcgatt cctggatcat gtcgagctct ccgtatgccg tcatgataat 3324601 gacccggatg ttttcgtcaa tgaccttcat ccgttttaag atttcgattc cgtccatgcc 3324661 gggaattttc atgtccaaca gcacaaggtc gggccgttct tttgtcacaa tgtcaagcgc 3324721 ctgcaggccg ttcgcagcct gaaacgtctg gtagccttct ttattgaaca cttcatttag 3324781 caaaatacga atgccgtatt gatcatcaac gattaaaatt ttttcattca tcattttaca 3324841 ccccaatatt atgattttcg tcaaaagtaa gcagtattgt atgtattctg tttgattttc 3324901 ctatttcctt taattataat agtctacttt acgacatttt ctgagcattt tctcttttgt 3324961 tgtatactga tattgtacgt tataaaggag gattcactta tgttgaaaat attcacgacg 3325021 cagttaacag gtattttttc ccgcattcag gataaggaat ctgacgcgat tgaagatggg 3325081 gcgcggctgc ttgctcaagc ggtgatcagc gggcattcca tttatttata cggagcgaat 3325141 gagcttcagg gcgtctttta tgaggccacc gaaagcaaag aacccttccc atctgtcaaa 3325201 gcctttccag aaaacgctga ggaagtgaca gaaagcgaca gggtgctgat gttttgctca 3325261 gggacgggca cagccgaaga acaggagctc gcaaaagagc tttatgaaaa aggtgcggga 3325321 gtcgtatgcg tatcgcccgc agccaaagac agtgcgggaa tagaacagta ttgtgatgtg 3325381 catattgatt ctaaattaaa aatgccgctt gttcccgatg aagacggcac ccgttacggg 3325441 tttccctctt taatgacagc actgtatgtc tatcacgctt tatcgtttac actaaaagaa 3325501 attctgcaag agtatgcata atatcttatt gtacatgctg gaacttgccg gaaacaaata 3325561 aaaaagactt gcccgctttt gacaaacggc aagtcttttt tattacttct gatttgcagc 3325621 ttcgacagac gctccgataa agcctttgaa tagaggctga ggtcttgtcg gtcttgactt 3325681 gaactctggg tggaactgag aagccacgaa ccaagggtgg tctttcagct cgatgatttc 3325741 aacaaggcgt ccatcagggc ttgtgcctga gaatacgaag ccttgctctt ccatttgctg 3325801 tctgaattca ttgttaaact catagcggtg gcggtggcgc tcgtacacca cttcatcctg 3325861 atacacttca aaggctttcg tgccttcttc aagcttacaa gggtaaaggc cgagacgaag 3325921 cgttccccca agatcctcaa catccttttg ttcaggaaga agatcaatga tcgggtattg 3325981 agttgacgga tcaatttccg ctgagtgagc gccttttaag cccaatacgt ttcgtgcgta 3326041 ttcaatagac gccacctgca tgcccaagca aatgcccaag aacggaatgt tgttttcgcg 3326101 cgcgtatttt gtcgcgacga ttttcccttc aacaccgcgg tctccgaatc cgcccggcac 3326161 aatgatgccg tctgttccgc ttgtgagttc tgcgatattg ttttctgtca cttcttccgc 3326221 gttgatccac ttcactttta catctgtgtc aaacgcatag cccgcatggc ggagagactc 3326281 gacaacagaa atgtatgcgt caggaagctc aacgtatttg ccgacaaggc cgattgtaat 3326341 cgtttgagac aggttgctga ctttgttaac aagctctttc cactcggaca tttccgcttc 3326401 tttgcatgcc aatttcatgt gctcgcaaac aagcttatca agcccttgtt tttgaagctc 3326461 cagcggaatg gagtaaaggt tgtccgcatc ttcacattca ataaccgctt ttgtatcgat 3326521 gtcgcagaaa agcgcgattt tatctttcat atcttgagaa atcggcattt ctgtacgaac 3326581 gacgatgatg tttggctgaa tgcccaagct gcgcaattct tttacgctgt gctgtgtcgg 3326641 ttttgttttt aattcgccag cagctttaat gtaaggcacg agcgtacagt ggatgtacat 3326701 tacgttttca cggccgatgt cgctcttcat ttggcggatc gcttcaagga atggcagtga 3326761 ttcgatgtct ccgacagtac cgccgatttc tgtaatgaca acatctgcgt ttgtctcttt 3326821 ccctgcgcgg taaacacggt ctttcaattc gtttgtgatg tgcggaatga cctgtacggt 3326881 tcctccaagg taatctccgc ggcgttcttt tttaagaact gttgaataga ttttacctgt 3326941 tgtcacgttg ctgaatttat tcaggttaat gtcgataaaa cgctcatagt gaccaaggtc 3327001 caagtctgtt tcagcgccgt catccgttac gaatacttca ccgtgctggt acgggctcat 3327061 tgttcccggg tcaacgttga tgtatggatc gaatttttga atcgtcacgt tcagtccgcg 3327121 gtttttcagc aaacgcccta atgaagctgc tacaataccc tttccaagtg aggatacaac 3327181 tcccccggtt acaaaaatat atttcgtcat ttcgtttgct cctctcttcg ctcttagcta 3327241 catttttaaa atgtactatt ttataaaaaa tcatttagcc ttttaaatga tttataagaa 3327301 aaatgagggg tgaaaataag aaagctccct ttcaatttct tgaaagggag cataacgtac 3327361 tatgttctct cttcgttttt gaagagccca aaatacatac tacatagttc gactatgaaa 3327421 gtcaagatcg ttttgaagat gaaatctgat actatttaat ttcctcttct tcatcatcat 3327481 agtcttcatc atcttcatca ataatatctt cttcgatctc aagatcatcg tcgtcttcat 3327541 caagatcttc ttcgtcaaaa tcgtcggctt caagatcgag ttcttcctca acttcatcca 3327601 aatcaaggtc gtcttcgtcg atctcttcaa actcgtcaag atcaagatct tcttcgactg 3327661 ctttcttcgc ttttttcttt ttcgccttga ctgtcggctg agtttcttca tcaagctgat 3327721 cataaggata ccagctgcga agcccccacg tctggtcaga aagcgccagg aagcggccgt 3327781 caatgtttaa atctgtataa aattgagcaa tgcggtctcc aagctcttct tttttcacgc 3327841 cgagcaaaga tgcgatttca tttaaaagct cctgaaaagg aactggtttt ttatgttctt 3327901 caaataattc gtgagcgatt tcaactaaag ccatttcctt tagctcttcc tgtgaatatt 3327961 gtttgatacc caaggtcgga cactcccttt ctattactta tatgtatctg ttttatcaat 3328021 aatgaaagcg attttgtatc gttcttatac aaaccatacc tctcattata aacaaaataa 3328081 aacagaatat gctaccctta acagcgttaa tttaaataat tttacaagag tgatccgact 3328141 gagagatgtt ttccgttaat ccgcgagcat tctggagatg accagtcttt gaatttcttg 3328201 agtgccttca tagatttgcg tgatttttgc atcacgcata tagcgttcta ccggataatc 3328261 ttttgtatag ccgtagccgc cgaaaatctg cacggcttcg gtcgttacct tcatcgccgt 3328321 atccccagcc atcagtttgg acatggcgga agcttttcca tatggaaggc ccgatgattc 3328381 taaccatgca gcctgatagg tcagtagcct tgaagcttct atcattgtcg ccatatccgc 3328441 gagtttaaaa gcgatgccct gctgctcggc gatcgatttt ccgaattgct ttcgctcttt 3328501 tgcatattga agcgccgcat caagcgctcc ttgggcgatg cctacagctt gtgcagctat 3328561 gccgtttctg cctccgtcaa gcgtcttcat cgcgattttg aagccttctc cttcttctcc 3328621 gagacgcttt gatgcgggca ctacacaatc ttcgaacatg atttccgttg tcggtgaaga 3328681 acggatgccc agcttctttt ctttcttgcc tgtaaaaaat ccttcaaaat ccttttctac 3328741 tataaaagcg gtaacgcctt ttttcttttt ctcgggatcg gtgacggcaa aaacaatgta 3328801 aatatcagca acgccgccgt ttgtgataaa cactttggaa ccatttaaca catagtcatc 3328861 gccgattcgt tcagcagttg ttttcatgct gccggcgtca gagccagacc ctgcttcggt 3328921 caaagcgaat gcgccgattt tctctccgag agccagctgt gttaagtact ctgtcttctg 3328981 ttcctctgtc ccaaaggcaa acagcggcca gctgcaaaga gagatatggg cggaaagcgt 3329041 cacaccggtg gaggcgcaca cttttgacag ctcttccacc gcgatgacgt aggctaaata 3329101 gtcacttcca attccgccgt aatcttcagg ccatggaatt cccgtcaggc ccagatttgc 3329161 catttcccga aacagctcgc gatcgaagcg ttcttgttcg tcccgttcag ccgctgtcgg 3329221 ggccacctca tgcttcgcaa aatcgcgcac caattttcgt atcatctcat gttcttctga 3329281 taatgaaaaa ttcattgctt ctcccccatt ttcagatcag cgcctaaaac ggattgagcc 3329341 agaagctcga cgacgtcgta cgttttgact tggtcttcgg cttccttcgc ctttgtgccg 3329401 tccccaagca tcgtgagaca atacggacag ccagaactga tcaccgatgg gttgactgcg 3329461 agcgcttgct ctgtcctggc gacgttaatc ctgttgcctg tttcttcctc catccacatt 3329521 aatcccccgc cggctccgca gcacatgccg gtttcccggc ttctctccat ttcaacaagc 3329581 tgcacgcccg gaatggcttt caaaatctct ctcggcggat catagacttc attgtaccgg 3329641 cccaaatagc acgaatcatg gaaggtaatc gtctcatgaa gcgggtgctg cggtcttaat 3329701 tttccgtttt tcacaagctc ggccagcact tctgtatgat gataaacctc gccttcaaat 3329761 ccgaaatccg gatattcgtt tttaaataaa ttgtatgcat ggggatcgat cgtaacgatt 3329821 tttttgacat catttttttc aaattcagaa atattcttct cagccagctc ttggaacaaa 3329881 aattcatttc cgaggcggcg cggcgtgtct cctgaatttt tttctttatt gccgagaatc 3329941 gcgaaggaca cgcccgcgtg attgagcagc ttggcaaagg aaattgcgat tttctggctt 3330001 ctgttgtcgt aagaccccat ggagcctacc cagaaaaggt actcaaattc ttttccttct 3330061 tttttcattt cttttacagt cggaatctca gcatccggcg cctcgtcacg ccaattttca 3330121 cgttccttgc ggttgagtcc ccacggattc ccttgccgct caatacttgt cattgcgcgc 3330181 tgggcgtcac tgtccatttt tccttctgtc agtacgaggt agcggcggag gtcgatgatt 3330241 ttatccacgt gctcattcat gaccgggcat tgatcctcac agttccggca agtggtgcat 3330301 gcccaaattt cttcctctgt gatgacgtcg ccgatcaagc ttggattgta atcaagcgcc 3330361 gctgcggctt cctgcgatcc gctgcccgct gacgccgcag ccagctgatt gcctctcgta 3330421 tgccgaaacg ctgctgcggg cacccatggg gagcgcgagg tgacggcagc gcctttttcc 3330481 gtgagatggt ctctgagacg caaaatcaag tccatcggag aaagcatttt tccggtgcct 3330541 gttgcaggac acatattggt acagcggccg cactcgacac acgcgtatag atcaagcagc 3330601 tgagactgtc tgaaatcctc aatttttccc gctccgtagc tttctttcgt ttcgtcggta 3330661 aaatcaattt tttcaagttt tccggcagat tccattcgat tgaaaaagac gtttgccggg 3330721 ccggcgatta aatgggcatg ctttgactga ggcacgtaca ctaaaaagct aagcaagaat 3330781 aggagatgga tccaccatgc gatatagaaa atcaccgccg cgcctgtttt cccgacaccg 3330841 ctaagcataa acgcaatacc tgaggcaatt ggctcgctcc aagaaagccc atgctcatgc 3330901 caaatcagat tcatcccgtt cccaagcaga acggtcagca ttaatcctcc gataaaaatg 3330961 agaacgagtc cggctttgaa accgcgtttc agcctcacga gcttttcgat ataacgtctg 3331021 tagaatgccc acccaacagc aattaaaatg agaaacgtaa caatttcctg aaaaaaggtg 3331081 aaggcgggat agaccgggcc aagcgacaga ttccggccgg gagccagtcc tttgatgata 3331141 aagtcaattg ctccgaactg aaccaatata aatccgtaga aaaacatgac gtgaatgatt 3331201 ccgcttttct tgtccttgag cagttttttc tgtccgaata cattcaccca tatggcgtga 3331261 agccgttcct tgaaccgttg atcaaattgt tctttctggc cgagcttgat gtaggccagt 3331321 ctcgttttga ccaagtaaac aaacaaatag acagcgtaag cggttacaat cagaaataat 3331381 aatgcatttg cgatgagaaa gccgctcatt ccaattcccc ctttttactg ataaagaccg 3331441 cgatccccta cccccgaatc tgtataagat tatctttatg ataaataatg aatgagtgtt 3331501 cagtcaataa ttaaattcct gctgttcggg cacactacct ttactacgga aaggagtgcc 3331561 ggtatgaagg tatttatcgt gattatgatc attgtcgtta ttttctttgc cttgattctg 3331621 cttgatatct tcatgggccg tgccggatac agaaaaaagg cgtacgagcc tgttttttca 3331681 aaaaagaaga gtgacatcga attgatccac tgcggcgctg atctcgttga gcggatgatg 3331741 aatgatattc gccaggccgc ctcttctgtt cacatgatgt tttttattat gaaaaatgat 3331801 gaggtcagcc acaatatgta taccttgctg aaaacaaaag cccaagctgg cgtatccgtt 3331861 tatttgcttc tggattgggc gggctgccgg gcaattaaaa aaacggcgct tcagacgatg 3331921 aaaaatgccg gcgtccatgt ccatgtgatg aatcgtcccc gttttccttt tttctttttt 3331981 cacatgcaaa aacggaatca ccggaagatt acggtgatag acggaaaaat cggttatatc 3332041 ggcgggttta atatcgccga agaatatctt ggaaagaagg cgaagttcgg caattgggag 3332101 gattatcatc tgcgcatgat cggagaaggc gtacatgatc ttcaaacgct ttttgcttct 3332161 gatctaaaac gaaataccgg aatcgaactg ggttcggatg tttggccaaa gcttcagcaa 3332221 gggactattt ctcacaagat ctatgcgacc gacggttatt cccttgaaaa catatacttg 3332281 gccaacattg cccaagcgaa gaatcgcctt acggtttgca cgccttatta cattccatca 3332341 aaaccgcttc aagaggccct tattaacgca agaaaaaacg gcgtatccgt gagaatcatt 3332401 gtaccgatga aatcagacca tccgctggta cgagaagcgg cttttacgta ttattcggag 3332461 ctcttggatg ccggctgtct tatttatcgt tattatcaag ggttttatca tgtaaaagcc 3332521 ctcatcatag acgaccatct cagcattatc ggaacagcca acttcgataa acggagcctg 3332581 ttcttaaatg aagaggtgaa tgttgaaatt gatgacgaag cgtttacaag tgaagtctat 3332641 gccacaattg aggaggatat gaaaaagtcg gagctgctga cgatggagga tttcagcaag 3332701 cgcacattca ggcagcgccc ggcggaatgg ctcggcaggg cattatctta tttcttataa 3332761 aggagagttc ctatgatttt cagattcggg ttcgtttcaa atgcgatgag cctttgggat 3332821 gcgtctcccg ctaaaacatt gacattcgcg cgttattcaa agctttcaaa gactgaaaga 3332881 aaagaagcgc ttctgactgt gacaaaagcc aatttgcgca atacgatgag aacccttcac 3332941 tatatcatcg gccacggcat tcctttgtac cgtttttcca gttcgattgt gccgctggct 3333001 acgcatcccg acgtgatgtg ggattttgta acaccgtttc aaaaagagtt tcgggagatt 3333061 ggagagcttg ttaaaaccca tcaactgcga acaagctttc atccaaatca attcactctg 3333121 tttacgagcc cgaaggaatc cgtcacaaaa aatgcggtaa cagatatggc gtatcactac 3333181 cgcatgcttg aggccatggg cattgctgat cgctccgtta tcaacattca tattggcggc 3333241 gcttacggaa ataaagacac cgccactgca caatttcatc aaaatataaa acagctgccg 3333301 caggagatca aagagcggat gacacttgaa aatgatgata aaacatatac aacggaagaa 3333361 acgcttcagg tctgtgagca ggaggatgtt ccgtttgtct ttgactttca tcatttttac 3333421 gccaatccag acgatcacgc cgacctgaat gtagcactgc cccgcatgat caaaacgtgg 3333481 gagcggatcg gccttcagcc aaaggttcac ttgtcttccc caaaatcgga gcaagcgata 3333541 cgcagccacg ccgattatgt tgacgccaac tttttgctgc cactgttgga acgctttagg 3333601 caatggggaa ctaatattga tttcatgatt gaagcaaagc agaaagacaa ggcgcttctc 3333661 cgcttgatgg atgaattaag ctccatccgc ggtgtcaaac gcatcggggg cggtgcgctg 3333721 caatggaagt cataaatgtg caaaaatagg tttacgactt gtcagctttg ggaacttagg 3333781 ctatataaga caacaatcga tggaggagaa agatcatgaa aaatatcaag tctctgaaag 3333841 tagccgcaca ggcctttact ttaagaaatt tgattcatct ttataaaatg tgccattccg 3333901 gaagccacga ggtttatatt tattcaaaga aaacgatgtg caaaatcaaa agcttaattg 3333961 agcttgaaac gttccgcatg gctcataatg aaaaggaata tctgatcgta gttgaaggaa 3334021 caaaagcatc acagctcatt gaaaaattcc aaaatctcat cgagcctgct gagagagaag 3334081 cgctctaact tacatacaaa aaaggataga catctgtcta tcctttttct tatgctctta 3334141 cataatggag ctgaaccgct tgtccaaatt gttttgtccc ttttaaccgc agttttgttt 3334201 catttgttag ttcgtgaaac agcgggatgc cgcttcctaa aacgacggga ataacagtga 3334261 tgatgaattc gtcgatggca tcttctttca taaagtcatt cacaagctct gccccgccag 3334321 ctatccagat gtttgagcct ttttcctgtt tcaaacgggc agtgaaggct ctggctccct 3334381 cattgataaa cgtcacatgt tcatcttgat aactgtcggg cgatcctgta aaaacatagc 3334441 aggttttatc ctgatacggg aaaaccggtg ttagcacttt aacgtgctca tatgtgctcc 3334501 gccctaaaat gactgtatca acagtctgat aaaaatcact gtagccgttg tcaccttcac 3334561 cttcaaattc atccagccaa tcgatgcttc catcttcttt tgcgatcatc ccgtccaatg 3334621 aaacagcaat gtacagcaca gtttttcttt ccatgttctc ctcctatcga tgcaccattt 3334681 gcccgaattg cgcttgatgc agcctgctgt ataggcctcc ggcttcgatc aggtcttgat 3334741 gacggccttg ttcttcaata ccgttgtttg tgacgactac aattctgtcc gcgtctttga 3334801 ttgttgccag cctgtgggcg atgacaagcg tcgtgcgccc ctcagacaac tcttgaagcg 3334861 ccttttggat cgccgcttcc gtctctgtat caagggctga ggtggcttcg tcgagaatca 3334921 agatcgacgg atttttcaag aacatccttg caattgacag acgctgtttt tgcccgccgg 3334981 aaagcttcac gccgcgttcg ccaatcatag tatccaaccc atcgggcatg ttatggacga 3335041 gctcttccag atgcgcctgc ttcacagctt gccaaatgtc ttcttctgat gcgcctagtc 3335101 ggccgtaggc gatattttct ctaagcgtgc ccgagaataa gaaaacgtcc tgctgcacga 3335161 cgccaatctg cccgcgcaac gaagaaagcg tcatgtcttt tatactgatg ccgtcaatcg 3335221 taatgtcgcc ctccgatgct tcataaaaac gcggaagcag actgcaaagc gttgatttcc 3335281 cagcacctga cggaccgacg aacgccaccg tttcccccgc ttgaatggat aggttgatgt 3335341 cattgaggac attgtgatgg tcatcatagc caaacgaaac atgtttatag cggatattgc 3335401 ccttcaggcc ggaaacatct ttcgaatcag gtgagtcctg aatatccggc tctgtctcca 3335461 tgagctccat atagcttttg aaacccgcga tccccctcgg atacatttcg ataatggcat 3335521 taattttgtc aataggcctg aacagcacat tcgtcaagag tacaaacgcc acaaattccc 3335581 cgtacgataa ggagccgcga atgacaaacc acgtcccgca caaaaggaca aacagcgtga 3335641 caaaccgggt cagcatatag ctgattgaac cgtttttcgc catgattttg taggaagaaa 3335701 gctttgtgac acgaaaacgc tggttgttga cggcgaagcg ttctttttca aatgcttcat 3335761 ttccgaacgc ctgcacaagc cggatgccgc cgatgttatt ttctacacgc gcgctgaagt 3335821 ctccgatatc cttgttcagc gtggtaaatg ctttggtcat ttttttgttg aaataaagcg 3335881 ctagccaaat gacgatcggc ataatgataa acgttaataa agcaagctgc cagttaataa 3335941 acagcatcac tccgaacgcc ccgagaatgg tcatgaccgc aatgaataag tcttccggtc 3336001 cgtgatgggc gacttcaccg atatacatta aatcgttcgt gagcttcgac atcagcgttc 3336061 ccgtcttgtt gttgtcgtaa aatttgaacg agagcttttg caaatggtca aaaagcgact 3336121 ttctcatatc agtctcaata ttgataccaa gcatgtgtcc ccagtaggtc acgatatact 3336181 gaagagccga gctgagcgcg tacaccgcaa ataacccgat tgaggtcgcg atgatcagtc 3336241 cccagtccct gcccggcagc aaggtatcaa taaaataatt gacgatcaaa ggaaaactca 3336301 gctccattaa acctcccgcg atcgctgaga aaaagtcgag aaagaacaac gttttatatg 3336361 gtttataata tgaaaaaaat tgccgcagca ccctatcttc ccccaatgta taaataactg 3336421 ataatatttc tcaattatac tatacacggg ctgttttgta agatcagatt tcttttttct 3336481 tacagaacac ctgaaaacag gcgggcaaac gactcttttg tccggtcagc cacacctctt 3336541 ttataaaagc cgacagggct gagcttttca ctttcctgca tatcctcttc aaaatgggcc 3336601 tcaagggttc ggatcgcttc ggcatccgtg aagaacacat tcacttcaaa gttgagctga 3336661 aagctgcgca tgtccatatt cgcggtaccg acggaggcga gatcgccatc aatgatcatg 3336721 actttttgat gcatgaagcc tttttggtag gagtacactt caatgccctc aaggagcagc 3336781 tccgggaaat aggacctcga cgcgtattgg gtcaaaaagc tgtcgttctt ctccggcacc 3336841 ataaccctta cctctacccc ctttgtcgcc gctgctttta gcgccgtgcg aatggattca 3336901 ttggggacaa aatagggcgt ggcgatccat attgatttct gcgctgaaga aatcatttca 3336961 taataaaggt cgctcatgct ttccttcatg tcagggcctg tcgcgacaat ttgataaatg 3337021 cctcctcctt ccacgggaac cggggtattg tactcctctt gatcaattag cacttcattg 3337081 gagacatatt cccaatccag cataaagata gcgtggagcg tttgcacaat ttccccctca 3337141 agccgcaggt gtgtatctct ccaaaatccg atgtacggat ctctgctgat atattccttc 3337201 ccgacattta atccacccac aaaaccggtt ttcccatcga tgatcacgat tttccggtga 3337261 tttctgaaat tcagcttctg gttgaaaaac ccgtatttca gcggagaaaa cgggacgatg 3337321 tccacccccg cttgtttcat tctcataata tctcttcttg ccagcttcat gcttcctgcc 3337381 gcatcgtata aaaacctcac ctcgacaccc tggcgcgctt tctccatcat aatatccatc 3337441 atgccgcgtc cgagcatgtc tgatttaaac atgtagtatt caatatgtat gtaagattcc 3337501 gcttttctca ttgctttgaa aatgtccggg aaggtttctt cgccgttttt cagcactttg 3337561 atgttgcttt tcgtattgat attcatatgg gcagccctga tggaatatgt aaagaacctc 3337621 tcttgattgt ccttcagccc tgtcacttcg ggcgtttcct ccttgtcaaa cagcttcctg 3337681 agcttttccc tgttgtacat tcgttttgtc ttaaacagct ttccctttac ataaagctgt 3337741 cccgaaaaca gataaaacac gtagccgacg attggaaaaa agacaagaat atggatccat 3337801 agcagcgtgt gctgcgaggt gcggttttca agaattaatg aatagatgct gaacaaaata 3337861 atgcttatat agcaaagcaa tcctccgtaa aactcaagtc tggaaaccgg aaaaaaccaa 3337921 atgacatatg ccccgatgag catcatatat aaaaagaaaa attccagtct ccttttcagc 3337981 atcctgattc tctccaatct gattcaatta cctctgtatt acctcttttt tctaatcgat 3338041 aaaccttgta agtaaaaaac ctctccgcca aaggaggaga ggtttagaga aaactaactg 3338101 tcacggaatt catccgcatc gtttctgcag aaataaagca agactattgg caacgccgag 3338161 tgacaacatg agcggcaagc tgaacccgct cagcactccg gcaagcgccg aaaagaaggc 3338221 ggcgctgtga ctgcaaatac ggtggataga gtaaatttga tacccattct gatgagagaa 3338281 aatatataaa acgggaaatt gatcagaaag atataaggag ttagtcaggc tgaatcataa 3338341 tctggctgtt ccgccggttt aaaatgagta aaatccttga tgttatttcc atatacaaac 3338401 ataacaggat tcccggcagc ccagccatta ccttggcaga aaaaaccccc tcttgcaagg 3338461 gggattttca cgagcgtttc cgatatacaa cgtagctgcg ggtcagatac ttgagcggca 3338521 gactgaacac atgaaccaat ctcgtaaacg gccacaggat aaaaacgacg tatcctatca 3338581 caatatgaaa cttaaaccat agcgggacac tctccatcaa agaggcgtca ggcctgaaca 3338641 aaacgatttc cctgaaccag ggcccgactg tggtccggta atcaaatcct ttcgaatcaa 3338701 tgttgagaaa cgtggccgca acgcctgaca gcatcatgaa cagcagcagg aggagcgtaa 3338761 ggatatcgga tggcgagctc gttttgcgga ttcttttgtc aaacagcctt ctgtacgtca 3338821 ggatgacaag tccggtacat gccgcaatgc ccgccggcaa gccagcgcca atcgccattt 3338881 tgtgatacat atgctctgaa atgccaaggg aagcatacac gccttctggg atcagaatcc 3338941 ccatgacatg cccgccgaca acgcacagca gtccccagtg aaaaagtgtg ctgccagccg 3339001 caagtttttt cttttctaac agctcgcttg atttcgccgt ccagccaaat tggtcatgct 3339061 gatagcggta aatatggccg ccgataaaga ttgtcaatac aatgtatggc ataatacccc 3339121 agaggatctg cccgctcatg cctgaacagc cccttcaacg ctttcacgta cgccaatgtt 3339181 ttcaagcgcg gccagcagca cgtgcagcag ttcagcgtat atactgtcat ttttttcgag 3339241 acgggatgcc agctccctca cattggacag atatttctca aacacgcttc tcgctgcttc 3339301 aatttctgca gccgcagcaa attccagcat cagcggcaga taatcaggca gctctttctc 3339361 tgtcggcagg aaaccggatt gctcgtatgt gttttttaaa tgcagcaatt caatgccgcg 3339421 ttccctttgc tcgcctgagt taaagtaggt gacatacata tttgtttttt tcccgaagtc 3339481 gaatgtatag acatagtgtt caatcagcgc ttccggagaa tagctggctg acgtctcgaa 3339541 aaagtgcagc agcttctccc ggatttgccg gttgccgatt tcttggataa gagccttcca 3339601 atcgggaagc tcggctctcc actcttcatc cggataagag agaagacagg aaagagcaga 3339661 gaacgtgatt tgccggtctg tggtgttcat cttgttacac ctcatttatc aaaagttaga 3339721 aacaggagcc ggggccgcct gaaaatgata agccgcagct tccttgttca gcgtataaat 3339781 ctgatacttc ttctcgatgg ctgctcggaa tcacaaagcg gtcatcatat ttggcaatcg 3339841 caagcagccg atacatatct tcaatttgct gttctgttaa gccgacactg gagatcagtt 3339901 ccggatcgat tgatttattc gtctggaccg ctctcatata ctggcgcatg acagacattt 3339961 tctttaatgt tgaccgaata tgatccgtat caccggctgt taacagctgc gccaaataat 3340021 ctatcgggat tctcatttgg tcgatagccg gaaaaatatc ttccgccgtt tgccggctgc 3340081 cttttccttc aaagagattc ataatcgggc tgagcggcgg aatgtaccac accattggca 3340141 gcgtgcggta ctcaggatga agcggcagcg cgatcttcca gtcaatgatc attttataga 3340201 tcggtgattg ctgcgcggcc tctatccatt cagccggaat gccttgttct tttgccagtt 3340261 tggcaacctc aggatcattc ggatcaagaa aaacgtccaa ttgggaatgg tagagatcct 3340321 tttcattttc aacagatgcc gcttcctcca ctttgtccgc gtcatatagc atgacgccga 3340381 ggtagcggat tctgccaaca cacgtctcag agcagatggt tggcagtccc gcctccaaac 3340441 gcggaaagca gagtgtgcat ttttccgctt tgttcgtttg ccagttaaaa tagacttttt 3340501 tataaggaca ggatgagacg caatatctcc atgaacggca tgcgttttga tccacaagca 3340561 caatgccgtc ctcctcgcgt ttgtacatgg cgccggatgg acaggatgag acgcatgccg 3340621 ggttgatgca gtgctcgcaa atacggggca aatacatcat aaagacgtca tcgaattctg 3340681 ttttgatcga ttcctccatc ttttgtacgt tgggatcttc aagtcccgta atgtggccgc 3340741 ctgcgagatc gtcctcccag ttcggtcccc attcgatatt catgaaatcc cccgtcaagg 3340801 acgatttcgg gcgtgctacc ggctggtgtt ttttctgcgg gctgttcgtt aatgtttcat 3340861 aatcatagtt ccaaggttca tagtaatcat caattgacgg ctgattcgga ttatagaaaa 3340921 ggcctgcaag ccgattggtt ttcgagcccg atttcagctc gagctttcct tttttcaatg 3340981 tccagccgcc tttatatttg tcctggtcct cccattgctt cgggtagccg atgcccggct 3341041 ttgtttctac attattgaag tacatatatt ccgcaccgga acggtttgtc cacgtgtttt 3341101 tgcaggtgac gctgcacgtg tggcagccga tgcatttatc caagttcatg accataccga 3341161 tttgcgcttt aatcttcaag ccaatcgacc tccttcagct tgcggatgac gacgttcagg 3341221 tcgcgctgat tccccgttgg accgtaataa ttaaagccgt agctgagctg ggcgtagcca 3341281 ccgatcatct gtgtcggctt gacgtgaatc cttgtcgggc tgttatgggt gcctccgcgg 3341341 ttattcgtca gctttgtgcc gggcacgttg atgtggcggt cctgggcatg gtgcataaac 3341401 gccattcctt taggaatccg atgagacaaa acggctctcg cgacgacaac gccgtttcgg 3341461 ttgaagcatt caatccaatc gttgtctttg atatccgtgt cctctgcatc atctttattc 3341521 atccacacgg tcggcccgcc gcggaacagc gtcagcatcg gcagagaatc aaaatacatg 3341581 ctgtggacag accatttatt atgcggcgtc aaataattga ggacgatttc ttttccctct 3341641 tgatcaggcc gtttgctcag aaacgggcga tgctggagga tcggtttgaa tgtcgccatc 3341701 gtttcaccga attccatcat cagttcatga tcgacataat aggattgtct gcctgtcagc 3341761 gtccgccacg gaattaattt ttcaacattc gttgtaaacg gcgaatacct gcgccctcct 3341821 ttttcagagc cggtaaacgc tggagacgtg atcaccgttt tcggctgggc tgtaatttgt 3341881 tcgaacgtaa agcattcttc ctcgcgttct tccgccaggt ctttcagctt caggttcgtg 3341941 atgttttcaa gtgattccca tgcttttact gcgacctttc cattcgaagt ggatgatagg 3342001 gttaaaatcg cttctgcagc ctgctttgct tcacttatat ttggacatcc ctttgccacg 3342061 ctgtccgagg tgatttctcc cagtctctgt ttgagtgatt catattcatc ggctattgac 3342121 cagctcatcc cttttgttcc gctcggcttt aaagcaacgt tcggaccaag tgcagtcatt 3342181 ttatgaaaaa tgtgtttgta atcccgttca acgacttgga tgttcggcat cgtttttccc 3342241 ggaatggctt cacattcgcc tttgctccag tcattgattt tgccgaatgg ctgggccaat 3342301 tcctgcatgg tgtcgtggag cagcggtgtc gcaaccactt ctttcaccgg ctccatatcg 3342361 acttcttctg ccagatcgga aacggctttt gacagcgcct tgaaaatatc ccagtctgac 3342421 ttcgattccc acggagccga gatcgcagga gcaaatggat gaatgaacgg atgcatatct 3342481 gtgctgctga gatcgtgttt ttcataccat gtcgccgccg gcagcacgat atcggaatac 3342541 agcgccgtac ccgccattcg aaaatcaaga ttgattaata agtcgagctt tccttccggc 3342601 gcctgctccc gccatttgat ttcttctggg cggatgctgt cgctgtcgtc attcattaaa 3342661 ccgttcgttg tccccagcaa atgcttgaga aaatattcat gcccttttcc tgagcttgag 3342721 atcagatttg cccgccatac aaagagattc cttgggaaat tcacttcatt gtcaggatct 3342781 tcaatcgcga atttcagttt tttctcttgg agctgtgagg ccacgtacgc acctacgtct 3342841 tcaggtgttg ctgcccctgc tttttcagct tctttataca gatcgatgcc attttgattg 3342901 aaagtcgggt aagacggaag ccaccctagc cgcgccgcca gcacattgta atcagcgtgg 3342961 tgcttgtagc gggatgaagc agcaatcggt gatgccaaat cactgatcgg ctggtcctca 3343021 taacgccact gatctgtcgc aaagtagaaa aatgaggtgc cattttgcag cttgggcacg 3343081 ccttcccagt cctttgcagt tgcaatcgtc tgccaccctt cagcaggtcg gagcttttcc 3343141 tgccccacgt aatgggccca gcctccgccg tttacgcctt gggcgcctac aagtaaaaca 3343201 agatttaaca ctgctcggta gatcgtgtcg gagttgaacc agtggttaat gccggcccct 3343261 acgataatca tggaccggcc gtctgtatcg atcgcatttt gggcaaactc tctggcaatc 3343321 ttaacgacag cttctttttt gattcctgtc atttgttcct gccaggcagg cgtaaacggc 3343381 tcagggtcat cataggagac agccgatcgt tcgccgatgc cccggttcac gccgtagtta 3343441 gccagtatca agtcaaacac ggtcgtgatg tacgtttctt caccgttcag gttcattttt 3343501 ttaataggaa gatcccgctc gagcactttg tttccgtcat ttgaaaaata cgggatgcgc 3343561 accgtgccga tttcgtcctc tattcccagc acagagagac ggggttcaat cggttccccg 3343621 gtttcttcat caatcatgtg caggttccat ttctgctgcc cgtcccagcg cgagcccatt 3343681 gtcccttggg gtatggcaaa tgaacttgtc tgttcatccc aaaccgcagg cttccactga 3343741 tcatgctttg tcttccgccc gatgtccttc gcatgcagaa accgtcccgc tgtgtatacg 3343801 ccattttctt ttgacagagt gacgagaaat ggaaaatcag tgtattgctt cgcgtactca 3343861 ataaaacgtt cagtttcttg gttcacgtaa aattcctgca gaataacgtg acccatcgcc 3343921 atcgcaagcg ccccgtcagt cccttggcga atactcagcc agtcatccgc gaactttgag 3343981 gattccgcaa aatctggact gatcgaaatg accttagcgc ctttatagcg ggcctccgcc 3344041 aaaaaatgcg cgtcaggcgt tctcgttaac ggaacgttgg agccccatgt gataatatag 3344101 ccggaattgt accaatcact gctttccgga acgtccgtct ggtcacccca aatttgcggg 3344161 gatgctggag gaagatccgc ataccagtca taaaaactga gcatagggcc tccgattaac 3344221 gacataaacc gggagcctga tgcgtggctg atcatggaca tggccggaat cggagaaaaa 3344281 ccgacgtttc ggtcaggccc gtatttcatc actgtataca gcagagaggc tgaaatcagc 3344341 ttcagcacct ccggccattc agcgcgcaca aaaccgcctt tccctctcgc ctgtttatag 3344401 gacttcgctt tttcagggtt ttcgacgatc gatttccagg cttccaatgg attttgatgc 3344461 gtctgcaatg cctcccgcca caaattgatc agcacaccgc gcacgtatgg atatttcaca 3344521 cggagcgggc tgtagatata ccatgaaaaa ctggcccccc gcgggcagcc tctcggttca 3344581 aaatcaggca tatccgggcc tgttgatgga taattcaaat tttgcccttc ccacgtgact 3344641 attccgtttt tcacataaat attccagctg caagaccctg tacagttgac gccgtgggtg 3344701 gagcgaacga ctttgtcgta ctgccatctg tttctgtata cattctccca atcgcgatcc 3344761 tcgcgggtag tttggctatg tttatttgaa tggtgttcga taggagagaa ataattcaat 3344821 ctcctaaaca acggactcct tttctttttc ttcatgagag ttcactcctt ccgagtcagg 3344881 tgatgctaag ttcactataa acagagacag cgtgtttcct tgtgaactat gtcacacact 3344941 ctgctttttt cacaaaatgt tcacacaaag gagaaggaag gctgcgttca ggcaggacgc 3345001 ttgggtcatt agctgccttt cattcaaaga tcaaaaaaaa ccggctctat ttaagaaccg 3345061 ggctcagcgt tttcatcctg tgatgtatgc agataccgca aaaataattg ataggaacaa 3345121 aaaacatttt gctgaagcat agccaaaaag ttcatttgca gctgcggatg ataagacatc 3345181 attttcttaa atatgtaata tgggatgttg agaatcagaa tgtctgaagt ggcattgact 3345241 gagataaagg gcgataaata aagcccgcct ttttcatcaa tcggaaacac atcgcctttt 3345301 tcccacagcg caacggtttt cgacccttca gggagccttg tgtccataaa acggacactg 3345361 ccttttaata caatataaac agattgagaa tgaagaaaag atggagactg atcacatgaa 3345421 ccgcggataa acgtgccgtt tttcagcaag gtttcgacaa tggatagagg cacttcatta 3345481 aacataggaa gttgtttcag aaataataaa tagtcacact gattcatagg aaaacctcct 3345541 gtgctaagga tagctttagt gtagctcgac tgagcctgta cagcagtgat gtatttcaca 3345601 gcctgtatga tgaatgtcac ttatcaggag ggtgaatgca tttataatga aagaaaaaag 3345661 gaggatttcg atgaaggcgc tgattccgaa gcagcacggg gcgtgggcga tgctgctgat 3345721 cccattttta ctcggcatgg tcaagggagg ccccgttatt tggcatattc cgctcttcct 3345781 tggttggctt ttcctatact tagcggttta tcccgttacg cttgccttaa aaaagaaaca 3345841 aagcaaacca tatcaaaagt ggatgtgtta ttacggtttt cccacctgct gctttttgat 3345901 gatctcggtc tttcataagc cgcctctcat ctgggtgggc gtttctttac tgccgctgtt 3345961 tctcatacat atgtattttg cccgcagaaa aaacgaacga gccttattga atgatgttgc 3346021 aggtgtcttg ttcttttgtt cgggcgggtt tgcgagctgc tggctgggga tgggaaccct 3346081 tgacggctgg gcttggttta ttttcttgca gtctgcttta ttttttatcg ggagttcctt 3346141 ttatgtgaaa tcggtgatcc gcgagagaaa aaacagggca tttgcatact ggtcatgggg 3346201 atatcacctg ctgctcccct ttttatccgc tcttttcgga gcaggatggg cgtttctcgc 3346261 ttttatcccg agcagcttgc gggcatggtt ttttcatgga agggattggc ccgtaaaaac 3346321 gattggcatt ctggaaatcg tgaatgcctg cttctttctt gccgtcatgt gcctgtttat 3346381 cacaaggtaa aaaaacaagg acaccgctgt ccttgttttt ttcagtcaat attgcaaatc 3346441 tccagcgggc aattttcaca ctcaatctca catcgtaaat agtcccgctt gtgcaaaata 3346501 atttttccgg attcgtctat cgaaataacc ccttttttgc ggagatctcc gagcatacga 3346561 ttgacgcttt cccgtgcagc cgcgcaaaac tttgccaaat cctgatttgt caggacaatg 3346621 ttaatcagaa tgccgtcgct tcgctccact ccgtagctgt ttgataagcg gataagggta 3346681 gaatagagcg cccccttttt gccatgaaga agcagatccc tgattttgga ctgaatcttc 3346741 cggaggtgcg tgctcatcca tttcatgaac tcaaatgtca aagcgccgtt ttggattaat 3346801 tctttttcca gcttattttt attaatgacg agcacctcgc catcctctag tacttttgca 3346861 ctgagcatat accttggttc ttcagtgaaa agtgttaatt ctccgacgat atcatgcttt 3346921 tggcagattc taagcgtcag gtcttttccg tcagatgtca gcttgccgat ttcaatgagt 3346981 cctgattgaa tcagataaag ctcttctgca tccattcctt cccgaaacaa atacgtgtgt 3347041 ttttccattt ttcttttcgt gctgatcgat tccagcaatt catacagatc gctggatata 3347101 agatcactat cagatggtcg aacagagaga aaattcatga gctcacctcg aagaaagtca 3347161 cgttgtgtgt ttattgtaac gtgaattgat ttgtacccat cgagaaaaaa ctaacaatct 3347221 tgtgaatgcc ccagtgttag ttgatgctct ggctgtttct ctccgtgtgt gttttcattc 3347281 tttcctgcca atacatccat atgacaagga caaaactggc taacgccacc tctgaaagcg 3347341 ccataaaccc gatcgcgtac tggcctgttg cctgaaatac actcgccaat atgagcggag 3347401 gaaaaaagcc gcctaaaccg cccatggcag acacaatccc attggcaatc cccgcttgct 3347461 tcgaaaaata gaaaggcacc agtttaaaaa cagttccgtt tcctatgcct gagcagacgg 3347521 ccacggttaa tgatccaaac gtataaaggc cgattgtcgg cgagaacgat aggataatgc 3347581 ctgataatgt aagcccggca aaaacaaaca tcaagatgcg gagcgggctc attttatcag 3347641 ccaggaatcc gcccgcaggc ctgagcagcg tagaaaccgc aataaagcca gccgtccgca 3347701 agccggcatc tgcaggattc agcccaaaat gctccaccag aaagttcggc agatagatag 3347761 tgaaggcgac aaaggcaccg aacgtaataa aataaaacag gctcagaaac catagcacat 3347821 gatttcggta aacagctttg atttgagtct taacagaaac tttgaccttc ttctcatgcc 3347881 tgtcgccaaa caatacgtgc agtaaggcaa agacagccag caaaatcaga tacatttgca 3347941 cggttgattt ccacccgacg gcttgagcga taaccggcgc tgcaaatgtc gtaacggctg 3348001 tcccgatatt tcctgcaccg taaatcccat tgacgacacc gtgcttttct ttcggataat 3348061 atttcgggag ggaggtcacc ccaatggaaa acaccgctcc cccgatccct aagaaaaagc 3348121 cgcctgcgat taaatcaaac agagaatccg cgatactgat ccaaaataca ggaaataaaa 3348181 gcaggatgaa gctgaccata aacatgagcc gcgcgccaaa cctgttcgtt aaatacccta 3348241 aaggaatgcg gagaagcgac ccgaggatca caggaatcgc ggtcactaaa gaaatctcac 3348301 ccttgcttaa atgaatatct aatgtgattt gggaaatgag tgatgaaatc agcacccaaa 3348361 ccataaaccc tgccaccaag cttaatgact gtaacgataa ttgaatgtgt tgacggttga 3348421 tcatttggct tgcccctttc aatgattcaa taatcagtct tatcatacaa aaactagcca 3348481 aacaggattg tgaattacat cacacgtttt tctcataaaa aaaggacaaa gcccgaagac 3348541 tttgtccttt tgatcgtgat tacatttttt ccggagccga tacgccgatc agctgaagcg 3348601 cattgttcag cgtaatttgc gttgccttca ttaaagccag gcgcgcgcgg cttttctctt 3348661 cattttcagg gtcgatgact ttctctgcgt tgtagaagct gtgcagagca gaagccagat 3348721 cataaatata gttagtgaca cggtgcggaa ttcgtttttc cgctgcttcc gccactgcct 3348781 ctgggaagcc gccgatcgtt ttcagcagat cgtattcttt ttctgattga atatggctga 3348841 aatcaagatc tgccgccggt ttaagcccct gctcttcccc ttggcgaagc atgctgcaaa 3348901 tacgggcatg cgcgtattgt gcataataca cagggttttc gttagatgtt gatacagcaa 3348961 gatctaagtc aaaatccata tgggtgtctg cacttcgcat tgcaaagaag taacgcacgg 3349021 catccaagcc gacttcttca atcaggtcac gcatcgttac ggctttaccg gtccgtttgc 3349081 tcattttcat tttctcgccg tttttgtaaa ggtgaacgag ctgaatgatt tctacttcaa 3349141 gcgttccttt ttcatagccc agcgcttcga ttgccgcttt catacgcggg atgtagccgt 3349201 ggtgatcggc gccccaaacg ttgatcagct tatcaaagcc gcggtcaagc ttgtccttat 3349261 gatacgcgat atcaggaaga aggtacgtgt acgtgccgtc cttcttgatc aatacgcggt 3349321 ctttatcatc gccgaaagtc gtggaacgga accaagtcgc gccgtcttct tcatagacgt 3349381 ggcctttttc gcggagcgct tcaagcgcct tgtcgatttt tccattttgg tacagtgaag 3349441 tttctgaata ccacacatca aacggcacac ggaagttttc caagtccttg cgaagctttt 3349501 ccagctcgta tttcaggccg tattcacgga aaaacgcgag gcgttcactt tcctcttcgt 3349561 taacgaaacg atcaccgtat tcctcagcga gacgctttcc gatcgcaatg atatcctcac 3349621 cgcggtagcc atcctccggc atcggttttt ccaatccgag tgcttcaaag taacggactt 3349681 caacagaaag cgccagattg ttgatttggt ttcccgcatc gttaatgtag tattcgcggc 3349741 ttacatcgta acccgctttt gaaagcacgt tgcacaagga atcgccgaca gccgccccgc 3349801 gcgcatgccc gaggtgaagg tctcccgtcg gattcgctga tacgaattct acctgaactc 3349861 gttcaccgtt tccgatgttc gtttccccgt atgcttcccc tgcttccagt acagacggaa 3349921 tcagctttgt taaatattga ttgttcatat agaaattgat aaaacccggg ccggcgatat 3349981 ccagtttttc aatcgaagcc ttccctttat caaaatgggc gacaatctct tcagcgattt 3350041 gacgcggcgc tttttttgcc actcttgcca actgcatcgc catattcgtt gagtagtcgc 3350101 cgtgtgtttt atctttcggt gtttctaaaa caacattggg aatctggctt tcttcagcca 3350161 gtcccgcttt cagaacggcc gctttgattt cttctttcag cacgtccttc atttgttccg 3350221 caatgttcat gcgtgagttc ctccctcata cgtgatcgtc atattatgta aatgctcctg 3350281 ctcgtctccg acatgcatgt catatgcgat gctgatacgg cctttttctt catcgagatc 3350341 agattgaatc gattttgtgc ttgttttcag ctcaagctca ccaaatgaca ttttatattt 3350401 agcaattgtg gaagctcccg ttacgaaacg ctgattcatt ttgacagcgc ctgacctcat 3350461 gaccaggact tcgccttcgc ttactttcac aatcgttttg actttgccta agtcgtgttc 3350521 ttcataataa gatagataca ctttattttg ttttacatag taaaatccgg tggtgcggaa 3350581 ttcgatgact tcttggtttc cgtcatcctc gatcacagac ttcacatgga gtgttatcgg 3350641 tgtctcttgc ttcattctga cacgtccttt tcatcattcc actttgactt gaatagtata 3350701 atcattcggt ttgtaaactt caactgcttc tatcttacca tcattgctca tcagatttga 3350761 agataaacct cataaaaagc atttccttat atagaagaga aaatcatatc actaattacc 3350821 tttaggaaat gttacgagct cgctacatcg caatcgcaga cggacccgcg ccaaccggaa 3350881 tcaccgtcac ggctgtataa tcacttgtgc ggtacacggt cacagcattg tcgttgggct 3350941 gtgccgcata aatatactgt ttgtccggcg ttacggcgag gtcaaaggcg ccggggagag 3351001 acacgtttgc aatgatcctc tgtctggccg tattaactac gtataagtta ttaatgagaa 3351061 acggttcact atatggctct agaaaataag ctctagtact atcgagagaa aatacaatcg 3351121 tcctcagcgt ttcaaataaa cggctgaagt cccctcccct gcttaatggt gacaaactaa 3351181 tctccgttac acctttcggc cacagctcac cattcaatac gtacgcaaaa tttccagcgt 3351241 aaggagttgt aattaaactg ggaaattcaa atgtatctat gatactttct accaactgcc 3351301 cagtatttac atcatattta tcaaccgacc aactgcttcc attagcggta tagacatact 3351361 gtccattcgg atcaagagca aagtctaaag cgccgggtat cggaatgaca tcaatgaccg 3351421 attgagaggc cgtgttaatc acatatatag atccggcggc catcacgtat gcgaactcat 3351481 ctgttggatc aaattcgatt tttctcggcc ctcctccaac agtaatggta tttatgatgg 3351541 ttaatgtttt attatcaatc actgagacaa ggttggtatt tccatggagg acatacgtga 3351601 atgctttatc gaaagtaacg cctagattag ttggcacgtc agaaaaaggg attgttttta 3351661 caacagtgtt taaatctgca tcaataaccg aaaccgtgct gtctccagta ttggcagtaa 3351721 acacatacga ttgagggtct ggtgatggcg gtaaaacaag tgtcccggcc accgtaagcg 3351781 gactgccgta gaaaggcggt acaatgagca gatcttccac tgttatttga ctgaaatcag 3351841 gacagcggcc agactgtgct gcataataaa caacttgatc aatctcttca gtatgaatca 3351901 cagaaacagc cccgtctcct tgtccatatt gatttcgtac aggcgacaca ctgacaagaa 3351961 gcgtaatggt cccttgtact ctcacagcat atcgaacacc gatatcttct ggttccggcc 3352021 cagtctggat taagcaaggc tcactgatac aggacaaatt gtctgtactc catgtaacag 3352081 ccgctgacgc ttcggccgta tcaaccttga agccctcagg gaaatctatc ggcacttgaa 3352141 acggcgcttc ccggctaatt tcctcatcac aaaaacagaa acaattttcc tgtaaagcag 3352201 aaagatcatt ctttttcatg atttcacgtc cttttagaaa tgcacaacat gcagcggtta 3352261 aatcgtaatg gcacccggtg aaaccccaag agatatcaca gtttcctcag aataatcatc 3352321 tgtgttgtaa acaatgatgc tctgctctat aaaacgagtt gcatacagaa aatcgccatt 3352381 cggggtaaac gcatagtctg ttgctgattg cggaacattt cctataacgc ctgctccatt 3352441 tggactgaca gaatataaat tgccagtgaa gccgtcatat aaatacacct ctgctccact 3352501 cgtaaacatt cgatattccc cttcatactc cagctcttgg gtgctgctga tggtaaacgt 3352561 atttaaatca ataaccgtca aataattaaa aaagaattct tgttctaata cataggcata 3352621 ccgctccggc caatttgttt ctatggttga tacgataagc tctcgttcaa ttgttcctgt 3352681 gacttcaccg gtagttaggt ccactttttg cactattcca aaattcagaa cataggcgaa 3352741 taacccattg ggatcgattg caacatcata tccttccaca ggaatcgacc tatccacagt 3352801 taacgtatca attccaatca cataaaccgc agtaccggtg aaaacataag caaactcatg 3352861 attagggata aatctaatca atcgaggcgg ctgatccagc aatatagttg ctgtcactgt 3352921 taatgtgtca taatcgatga cagaaatcac attattgttg ggatgtaaga caaacacagc 3352981 gcttttatct ggcgtaattt caatacctgc cggattgtac ggaagagcaa tcgttgtcac 3353041 aacagtatcg gtgtttgtat caatcacaga aactgattga tcatttggat tcgctgtaaa 3353101 cgcgtagacg ggttccggct ccggtacaag cacaattgtc cccgtcaccg ataaaggact 3353161 gccgtaaaac ggcggaacaa caacaaggtt ctcaatcgtg atgtcactga tatccgggca 3353221 atcatccgat tcatcggaat aatagacgac ttgatcgatt tctgcattgt gaatgacgga 3353281 aacagccccg tccccttgtc catattgatt tcggacaggt gagacactga cgagtagcgt 3353341 aacggttccc tgcaggcgca ctgcaaattg aacaccgacc tcatcaggct caggccccgt 3353401 ttgaattaag caacggtcac tgacacaaga aaggctgtct gcattccacg tcacgtttgc 3353461 aacagcttca gccggatcaa cgacaaaccc ttcaggtaat tcaatcggtg cttgaaacat 3353521 ggcttctcgg cttgcttctc cctcacaaaa acataagcac tcttcttgtt ctgctcctgc 3353581 tttttcttta aaggaaagct tgttttttct cattccttca cttccttttc agacatacac 3353641 tgctcacgca gatataacag aatatggaag ggtaacgtgt ttgcttgtac aaattgctga 3353701 gggtaaacgc ttctttttga aaatatatct ccaaacatgc ggtgtaacga aagaaaaaat 3353761 tgcggttttt ttgcgcttct cacaagaatg ttgatgataa aatatgacat atatagaatt 3353821 atgaagggag ggatttgcaa acgtgacagg tgtcatatct tcttcttcca tcggagaaaa 3353881 gattaacgaa tggtatatgt acatacgccg attcagcata cccgatgcag aatatttgcg 3353941 acgagaaatc aagcaagagc tggatcaaat ggaagaagat caagaccttc atttgtacta 3354001 ttcactgatg gagtttcggc acaacctaat gcttgagtac cttgaaccgt tagaaaaaat 3354061 gaggattgag gaacagccga gactgtctga tctgctgctt gagattgata aaaaacaggc 3354121 tcgtttaact ggtctgcttg agtactattt taacttcttc agaggcatgt acgagctgga 3354181 ccagcgggaa tatctgtcgg ctattaaatt tttcaaaaag gccgaaagca agctgatatt 3354241 cgttaaggat cggatagaga aagctgagtt tttctttaag atgtctgaat cttattacta 3354301 tatgaaacaa acgtattttt caatggacta tgcacggcaa gcatatgaaa tatacaaaga 3354361 acatgaagct tataatataa gattgctgca gtgtcattct ttatttgcca ccaatttttt 3354421 agatttaaaa cagtatgagg atgccatctc acattttcaa aaagcttatt ctatggcaga 3354481 agctgaaaag cagccccaat taatggggag aactttgtac aatatcgggc tttgtaaaaa 3354541 cagccaaagc caatatgagg atgccatacc ttatttcaaa agagcaatag ctgtttttga 3354601 agaatcaaat attcttcctt ccttacctca agcgtatttt ttaattacac agatccatta 3354661 taaattagga aaaatagata aagctcatga atatcatagt aagggaatgg cttattcaca 3354721 aaaggccgga gatgtaatat atttatcaga gtttgaattt ttgaaatctt tatacttatc 3354781 aggcccggat gaagaagcaa ttcaaggatt ttttgatttt ctcgaaagta aaatgttgta 3354841 tgctgatctt gaagatttcg ctattgatgt ggcaaaatat tatcatgaac gtaaaaattt 3354901 tcaaaaagct tctgcttatt ttttgaaggt ggaacaagta aggcaactta ttcaaggagg 3354961 agtgagtttg tatgaaattg aagtctaaac tattactctc ttgtctggct ctaagcactg 3355021 tgttcgtggc aacaactatt gcaaatgcac ctacacacca aattgaagtt gcacaacgag 3355081 gaatgattta accgccgtcc atcggcggtt ttttcgtccc ctctttacca aagtctccca 3355141 atccatgcta tgatcttttc aataatcttg aagagagtgg aaatgcagca tgtctctaaa 3355201 aagtgtgaga acccacttta ctcaatggaa tcgagaaaat gatgtgacgg agttcgaaac 3355261 gtcgagtgcg acagttgaac aggcagctga gacaatcggc gtaagcctgt ctagaatcgc 3355321 caagtccctg tccttcagag gggaaggaga tcaggtgatt ctgattgtgg cagccggcga 3355381 tgccaagatc gacaacaaaa agtccaggca aacatttggc tttaaagcaa gaatgctctc 3355441 tcctaatgag gtgctggagc agacaggcca tgaaattgga ggagtttgcc catttggatt 3355501 ggctcatgat cctgaggttt atcttgatgt atcgctgaaa cggtttcaga ctgttttccc 3355561 cgcatgcggc agcagaaact ccgctattga attaacaccg aaagaattat ccgaattttc 3355621 tttctcaaaa gtgtggattg atgtttgtaa agactgggaa taaaaaaaca tccagacatc 3355681 gtctggatgt ttacttattt cacaaaccca agcagcattt cacggatgat tttgctggct 3355741 gtgtttgccg tttgctctga gtggtcgtat accggcgcga cttccactaa atcagcgccc 3355801 tttacgttta cctctgaacg cgcaatttca tggaccgatg caagcagttc tttagacgtg 3355861 atgccgccgg cgtcaaccgt tcctgtaccc ggtgcgtgtg cagggtctaa tacgtcaatg 3355921 tcaattgtga cataaaccgg acggcccgcc agcttcggaa gcacctcttt cagcggttca 3355981 agcacttcaa attttgagat gtgcatgccg ttttccttcg cccattcaaa ctcttctttc 3356041 atgccggaac ggattccgaa tgaatacaca ttgtgcggtc cgatcaattc tgccgcctta 3356101 cggatcggcg tggagtgaga aagcggttct ccctcataat caacacgaag atctgtatgt 3356161 gcgtcaaaat ggataatcgc aaggtctggg tatttcttgt acatcgcttt aatgacaggc 3356221 catgacacga ggtgctcccc gcccataccc attgggaact tccctttttc taaaatgctg 3356281 tccacgtact cttcaatcat atccaggctt cgctgcggat ttccgaacgg cagcggaatg 3356341 tcgccagcgt caaagaagtt caagtcagcc agatcgcggt ctaaatatgg gctgtattcc 3356401 tcaaggccga ttgacacctc acggattctg cttggaccaa agcgtgagcc cgggcgatag 3356461 ctgactgtcc agtccatcgg catgccgtaa agaatggcgt ccgcctcttc ccactcggga 3356521 cggctcgcga taaatacttt tcctgaataa gcttcatcaa atctcatcta taataccctc 3356581 gctttcctgt aaaaaagcgc aagattcgct cctgcgccat accttcatta tttaatcagg 3356641 tcactcacaa atttcggcag aacaaacgcc gctttatgaa tatcttttgt gtaatatttc 3356701 gtctcaatat cgaagaaacg gctgtcttcc actgcaagcg gatcatattt tttcgagcca 3356761 attgtaaatg tccacaaacc gcttggatat gtcggaatgt tcgccgtata cagcttcgta 3356821 atcgggaaga tttccttcac gtcgcgctgt acatttgtga ttaattccgg tgtaaaccat 3356881 gggttgtccg tctgcgcaac gaaaataccg tcttctttca gcgcttttgc gattcctgcg 3356941 tagaatcctt ttgtaaacag gtttacagcc ggtccgactg gttcagtcga atctaccatg 3357001 atgacgtcat attgattttc agattttgca atgtgcataa atccgtcatc tacctgcacg 3357061 tcaacgcgcg gatcatccag tttgcctgcg atagaaggaa ggaacttttt agagtattcg 3357121 ataaccttgc cgtcaatatc tacaagtgtc gcttttttca cgcttgggtg cttcaggatt 3357181 tctctgataa cgccgccgtc accgccgccg actacgagaa cgtgctccgg atttgggtgc 3357241 gtgaataatg ggacatgcgc caccatttcg tgataaacga attcgtcttt ttcagatgtc 3357301 atcaccatgc cgtccaaaaa aagcatgttg ccgaactctt ctgtttccac catttctaaa 3357361 tgctgaaact ccgtttgttc tgtatgtaac gtcttgttaa ccttcatcgt aatgccaaag 3357421 tttttcgtct gcttctctgt gtaccaaagt tcgctcaatt gtcatctccc tttcgaggct 3357481 gtattcattt attgtaagcg tcttatcagc ttttattctc ggttgaaatc tcattttcac 3357541 ctaaggaaaa agtatagagg atggcgggga aaaagtaaag atgcgtcctg ttctgcgatg 3357601 tttaaaaacg atcttttttt ctcataatag tagaaacata aaaaaagggg gaacccgttg 3357661 tggatgcaat gacaaataaa cggctgagac tgacgctgaa aaccgttcgc gcctttatct 3357721 ttttaggggc ttttgcggcc ttggcggcag ctgctgtgtt tatgactgtc attttgatag 3357781 ccaaatacca gggcgctccc tcggtgcaag tgccgcaatc cacgattttg tacgcgagtg 3357841 acggctcaaa gctcggggaa acgaactacg gcgaaaagcg ctattgggtc cccttaaagg 3357901 acatgaatcc gacgatcgta aaagcgacag tggcgattga agaccagaat ttctacgatc 3357961 atcacggctt tgattataaa cgcatggccg gcgcggcgct tgctgacctg aaagcatttg 3358021 ccaaggttca gggtgcaagc accatcaccc agcaatatgc gagaaactta taccttgaac 3358081 acgacaaaac gtggaaacgg aaatggaatg aggcgttcta cacgatccgt ctggaacaaa 3358141 actattctaa ggacgagata ttagaaggct atttaaatac gatttactac ggccacggcg 3358201 cctacggcat tgaagcagct tcccgcctgt atttcggcaa gcatgccaaa aacctgacgg 3358261 atgcggaggc ggcgcttttg gcaggaatcc cgaaaggccc ttccggctat tcaccgtatg 3358321 tcaatgagac gaaggccaag gaacgccaga aaacgattgt gcggatgatg gaaaagcagc 3358381 agatgatcag ccaaaagaaa gcggatgaat tgatcaagga acctctttcc tatcagcctt 3358441 tgaataaaca agtttccaag agaaaggctc cttatttcta cgacaatgcg atgagagagc 3358501 tggaaaaaaa gctcggcatg acacgggagc aaattgaaac gagcgggtta aacgtctata 3358561 caacggtaga taaacggatg cagcgcatcg ccgaggagac cattaccgaa acggttaacg 3358621 cgggctctga cattcaagtc gggttttcag ccattgatcc ccgcaccgga aacgttctcg 3358681 cccttgtcgg cggcagggat tatcaaaaaa gcccgtttga ccggacgaca caggcgaagc 3358741 gccagcctgc ttcgacgatc aagccgttgc tgtactataa agcgattcag agcggattta 3358801 cgccagtcac tttgatgaaa agcgaagaaa ccgagtttca aattgatgca aagggagaaa 3358861 cctattctcc aagcaactat aacggatact atgccaacaa gccgattacg cttctgcagg 3358921 cgctggcgct ttccgacaat atttacgctg tgaaaacgca tctttttctc ggcacgaaca 3358981 aacttgtaaa gacggcaaag gaattcggca ttaccgccca tcttcaagca ctgccgtccc 3359041 tggcactcgg caccgaaccc gtacgtccga ttgagatggt caacgcctat gccatgctcg 3359101 caaatggcgg aaagaaaatc gaaccgactt ttatttcaag agtaacggac gcagccggcc 3359161 acgtgctgta cgaaaacccg aatcagcata aacaggtgct tgatgaaaaa gccgcttttg 3359221 tcacagcgag tatgatgaca ggcatgtttg atatcgattt aaatggatat acgtcggtta 3359281 cggggcgaac gatagccaac cgcctgacaa gaacgtatgc cggaaaatca ggaaccacca 3359341 gcgcagacag ctggatgatc ggcttcaatc cgaagctggc cgccggtgtt tggaccggct 3359401 atgacaaaaa cagcaccatc gactcggtcg aagaaaaaag ctatgctaaa accatttggg 3359461 cggacttcat ggaggacgcg ctcaaaggcg aaccggaaac cgcgttcaag ccgccaaaag 3359521 gcgtaaccgg tgtgtacatt gatccggaaa caggctactc atcaggtccc ggctgcgccg 3359581 ctaagcatta cacatatttt gtgaaaggga cagaacccgc aaacgtgtgc tacggggcag 3359641 aacccgcaaa acaaacaaaa gaccggcttc catccaaaga aaagcccgct tccgagaaaa 3359701 agtggtggga caaatggctg gggcgacatc attgaaaata acccggctcc tcggaggccg 3359761 ggttattcgt atggttcctt cataatcgat ggaagaatgt tagacaatcg agctgaacaa 3359821 tcagttttgg gataaagtgg tgaatttctc atttcttcgg cgctggcttt catctcccag 3359881 tcgccgactc atatccccct aaaaatgaaa aaccccgagt cttgtttcgg ctcgggattt 3359941 tccatgtcct atttctgtat caccagttta ctcaatgttt acgaaaaata tctcaaatac 3360001 tttaaaagtt cacaaaaaat tcataaatta attgttttct ggaagcaggc tcgtttttaa 3360061 ctcatctgag gaacggtccc ataggccctg atcatgcttt ttcagaaatt cgcctagtac 3360121 acgcttcgag ctgtcgtcca ttttatcaac gatgattttc cgtttcatgg atttatccat 3360181 cagattcaca tgctcaggca gtgacttgta gcctcttctg atgcttctgt cgaccgtcat 3360241 ttcacaggct gtcacaccag cgtaataagg cccctcttct tttctgtcaa tcgttaccca 3360301 cacaagccag tatggttttc cgttcggcac ttcttcttta ttcgggagaa atttaattcc 3360361 tttttcaacg gtgctgcggg catgcatagc gccgatgtct acgaacgctt ctttttcctc 3360421 tacatcaacg aatacgggag aaatgttatc aaggctgagt gcccctacgc caaaaccgcc 3360481 gtgtccgtct gtcggatcac ttttgataat attaaacccg attgattttt tctttttttc 3360541 ttccatgaag ttctacctcc tacaaaagcg gttgaaatat cgctgaaaac agctttaaaa 3360601 tcgaatctct tcctgcattg agcatcggcc acagcacgta agatcctagc ggtgtcacaa 3360661 acagcaccaa aaatacgata aagccgtagc tctccgcctg cgtcattttg gcacgcacgc 3360721 ccggcggaac gagatcttct ataattcgat agccatcgag cggaggaagc ggcagcagat 3360781 taaataaaaa caagacaaga ttcagctgta tccaaataga aaaaaactga tccagccccg 3360841 tgctgaacgc cgcaagcatt tccattccgt acgcatgcat caacactaac aaaaagaaac 3360901 caataaacgc aagaatcagg ttactgacgg gcccggctat agatacgagc acaccagcaa 3360961 gccggggttt cttaaagaaa cggcgattca cgggaatggg gcgcgcccac ccgaatccgg 3361021 ccaccagaat caaaatggtt ccgaacggat caaggtgttt aatgggattc agcgtcagtc 3361081 ttccttgttt tttcgccgta tcgtcaccga atttgtatgc gacataagcg tgggcaagct 3361141 cgtgcatcgt aaacgacaca attagcgtga tgacgaggta tggcattaaa gataacggat 3361201 aatataaaaa acggtccaag tgagatatcc ctctttctca aaatgcaaga atttacttta 3361261 ttcagtatac tataagaagc ctctttttct aaagagagga aacgagataa aggaggattc 3361321 agcacccatg ccatacgtaa ctgtcaaaat gctcgaaggc cgtacagacg agcaaaaacg 3361381 caatcttgtc gagaaagtaa cagaagccgt aaaggaaaca accggtgctt ctgaagaaaa 3361441 aattgttgtc tttatagaag aaatgagaaa agaccattat gccgtcgcag gcaaacgcct 3361501 gagcgatatg gaataatctc tataaagccg gcgcttcgcg caccggcttt tattatccct 3361561 attgagccag cttcgcaata atcgccaaga acgtcttttt ctcttcggct gttaaacgtt 3361621 caaacatgcc atcaatcagc tgctggcggt tttcgatcat ttgttcagcc gctccccggc 3361681 ccgattcaga aagagtaatc catacagtgc ggcggtcatt gttatttctg gatctctcaa 3361741 taaacccttc ctgctctaaa tgattcagag ctgtggtcgt ggcagaggga gacagtgtga 3361801 cctccttcaa aatatccttt atggtgcagc tcccatgtct gtatatgatc cgcagaataa 3361861 accctcttac attattcacg tgtttcggaa cggtggcttc atctaattgc ttcgtgcttt 3361921 tcaaatactt tgtaagtgcg tgatccagca aatttgcttc cagtttgtca tggtccatgt 3361981 caatttcccc atttcgagat gcattcataa catacgaacg atatgattta cttattattt 3362041 tactgattcc gaatagggaa agtcaaaaaa gcaaaatgtg aattcacagc ttttatccta 3362101 catgcctcga ttttccacct gtttcacaag tttatcttta aaagtttgga aaggaacgtg 3362161 ttcattctgc tgatgtccga atcggcggac gtttaccgca ttctcctgct cctcatgatc 3362221 tccaagcacc agcacgtacg gaattttttg cacctgcgat tctctgattt tatagccgag 3362281 cttctcattg cgctcatcaa tgccggctct tatccccgcc tgcttcagct ccgcctgcac 3362341 ttttctgcaa tagtctaagt gaacgtgcga aaccggtatg atttgaacct ggatcggtgc 3362401 gagccagact ggaaaagccc caccgtaatg ctcgatcaaa atgccgaaga aacggtcgat 3362461 tgagccgaaa accgctctgt ggatgacaac gggacgaacc ttctcattga gttcgttgat 3362521 atatgttaaa tcaaattttt ccggcatttg aaaatcaagc tgaattgtcg cgcattggtg 3362581 gctccgtttc agggcatctt ttatatggaa atcaattttc ggcccgtaaa acgccccatc 3362641 gccttcattg atctcataag agaggccaag ctcctcaagg acgcgtgcta aggcacgttc 3362701 cgacgcttcc caaaggctgt catcgcctaa tgaatcctcc gggcgagtcg aaagctcaac 3362761 agaatactcg aaaccaaatg tccgatatac ctcatcaatc agccgaatcg cttctttgat 3362821 ctcactctca atctgatcct cccgaacgaa aatatgggcg tcatcctgac agaacgtccg 3362881 aacgcgaagc attccgttta aagcgccgct gtattcatgg cggtgcacct gtccgaattc 3362941 cgccatgcga atcggcagat cccgataaga atacaggctg tttttaaaga tgagcatgtg 3363001 gccggggcaa ttcatcggct tcattgcgaa tcttgtatca tccacttctg aaaagtacat 3363061 attgtcgcga taatggtccc aatggcctga ctgctcccat aaccgctgat tcatcataaa 3363121 cggcgtacgc acctcatcgt agccggcatt tgtttgcagc tcacgcgaga agcgctccag 3363181 ctcattgcgg acaatctgcc ctttcggcaa ataaaacggc atccccggcg cttcttcaga 3363241 aaacataaac agccctaact gtttgccgag cttgcgatgg tctcgttttg ccgcttcttc 3363301 tagcatatgc aggtgcgcat ccaaatcttt tttcttttga aacgcaaccc cgtacacccg 3363361 ctgcaggact tcatttttgc tgtctccgcg ccaataagcg cctgatactc ttgtcagttt 3363421 gaacgccttg atcatccctg tagaaggaag atgcggccct cggcacaggt caacgaattc 3363481 cccttgctgg tacagtgtga tatcctcccc gcgcggaata tcctttaaaa tctcaagctt 3363541 gagccgctcg tctttttgtg caaacagctc ttcagcttct tcgtaagaaa cctctatacg 3363601 tttgatttca aggttctcat ttattatgtt tttcatttct ttttcgatgg cctctaagtc 3363661 tcctgatgcc aagcttttcc ccagcttcat gtcatagtag aagccgtcta aaatcacagg 3363721 ccctaccccc aatgacactt cgccgtacag ccgttttact gcttgggcca gcacgtgcgc 3363781 tgttgtgtgg cgaagcacct gcaagccttc ttgtgaatcg agtgtgacaa tcgaaagctc 3363841 agcatcctcc tccagcttga aactgagatc aacaagcttg ccgttgacct gacctgcggc 3363901 cgccttcttt tgcagactgg aactgatcga accagccgct tctttgattg tgatgccttt 3363961 cggatattcc tggatctgtc cgtccggaag ctgaatgtgt acatgtttgc tcattttaga 3364021 acactcctta ttcattgttg tatataaaaa aacacacccg tcccgcagat agggacgagt 3364081 gtgtgattaa cccgtggttc cacccaagtt cccgacaaat actatgttgt cggctcggtg 3364141 ctgtaacgca gcatagacgg cattggttac ttcagttccc caatgctgct ccaaggcggt 3364201 aaatgatatt cctaagctgg gaagctctca cctttccttc cctctctgaa aaccgtaact 3364261 atcattcatg tccttttcat cgcatgtatt caattcataa aaaaacacac ccgtcccaca 3364321 gatagggacg agtgtgtgat taacccgtgg ttccacccaa gttcccgaca aatactatgt 3364381 tgtcggctcg gtgctgtaac gcagcataga cggcattggt tacttcagtt ccccaatgct 3364441 gctccaaggc ggtaaatgat attcctaagc tgggaagctc tcacctttcc ttccctctct 3364501 gaaaaccgta actatcattc atgtcctttt cttcgcatgt attcaattca aataaaaaaa 3364561 cacacccatc cctctaaaag ggacgaatgt gttgatcatc cgtggttcca cccaaattcc 3364621 cgatcaatta cacatgatga tcggcttaaa gatgctgtaa cgcagcatga cggtatcaga 3364681 tacttgtttt ccctgatacg gctcaaaggc ggtaagctgc tttccctgcg ttaggaagat 3364741 ctcagctgtc cttccctctc tggaaaccgt aaaaagcatc tcgtgtcctt atcagtgcct 3364801 gttgtttcaa taatttttta tatcttacta tatattccca caaagcgcaa tcagtgattt 3364861 acattttttc tgacgcggca gtcccgttat gggcagccag aaacagccat acaagcaatg 3364921 cagcgaggct gtatgccgct cccatcatca aaaacgcaaa cccggcacca gcataccaag 3364981 tggcggacag atgaatgatc accccggtta tcgctacgcc gaccaaggct ccgatttgcc 3365041 ggtttgcatt taacgccgca ccggcgatat tcgtatgtct ttgcccggca gcctgcatga 3365101 tcacagttgt catggcagga actgtaatac cggtacagag gttcataaca gacatcaaca 3365161 ccgccagctg ccaataagga aaatccggag aaatcagcac aaacaacagc aatgcaatga 3365221 tacagctgac cgccattgat acaaacataa gctgaccggc ttcaaaccga ttcgccagac 3365281 gggcaaacag cagattgccg atcacgaaga ccgccatcat cggcagcagc tccactccag 3365341 ccataaagga acttgcccct cctgcttcct gcaaaaaaag gctgagcata aacatgccgc 3365401 caaaaagggc gaaattcagc aaaaacccga taaattgggc agctgagaag cggccgtttt 3365461 tgtataagga cgccggcagg atgggtgttt ttgcagaaat ttcccgcagc aaaaacagca 3365521 caaatgccaa aaccgctgca gtaaatgcta caagaatcac tggcgagcgc cagcccgctg 3365581 aaggcccctg tatcaaagca taggaaagaa acccgagagc catcatgcca agcagatgcc 3365641 cgatgatgtt cacgcggctg cttttcccag gaacgcggct gaggattcgg taagctgaaa 3365701 tgagcgcagc agcccctatt ggcacattga tcagaaaaat actctgccag cccgccaact 3365761 gtaccagcac gcccccgata aaaggcccaa gggctgaagc ggcggaaaca agcgcggccc 3365821 acagtccaaa cattctcgcc cgcgcccgct catcaaggta agaggcagcc aaaaggctga 3365881 gtgagcttgg cataaacaaa gctgccccaa ttccctgtat gagacgtccg gcaatcagca 3365941 tctgcccatt tatagatgca gcgcatagac aggaggccat aacaaaaacg gctagaccca 3366001 agatatagat cgtcttcgag ccgaaacggt cagccaaggc tccgcccgcc agcagaagcg 3366061 acgcaaaagt aagaatgtac ccgtccacaa cccacgttac acctgaaagt gacattgaaa 3366121 gagtgttttt catatcagcc atcgccacat tcacaacggt cacatcaaga gttgccatga 3366181 ggaaaccaag tgcgagcacg atcagcacgg atatgcctgt tgatgatgtt gattcttgta 3366241 tagacccgct atttttcatt acaattgccc tttcacttgc ttgattaccc aatcatctat 3366301 tttttcaaga tcatacaatt ccccgactct gtccataaca tgctgcaagg attcttctct 3366361 cataagattg gaccatttat cctcgatttc cgccatgact gtctccagca cacagtgact 3366421 ttcaccctca aatacagatt gcagcaagcc tttcccctga tacatcgaac ctctgccttc 3366481 gaccgcttga taaacatcat aaagcgtaat gtcagccaaa ggcttcgtca gggtaaaacc 3366541 gcccttcgtc cctggtaagg attctgccaa accggcttga accaatgttc tcatcagctt 3366601 cttcaagtaa gacggagaca cgcgcaatcg ctggcttata gcctctgacg tcaaagaagc 3366661 ctgtaccggc agccgtgaca gtaacagcag cacagaaacc gcctgctcca ttcctgattt 3366721 cattttcatc ctattcactc ctgattcatt atggataact attatccata atgaatctct 3366781 tagcagcttt tgtcaataaa aaaagcaaaa gaaacggatc atttcttttg cttggtatgg 3366841 ttaacaaatc tgcttcagtt cctctatgta ttgaagcgct tcgtcatatt cttcatttgt 3366901 atatttttgc ttgcttttga tggtaaagac tttttctttc ttttcctcat cctcaagccc 3366961 gtcaaagtaa aggatcgtgg aaaccagctc taaaaaccgt gatgaacggc tgtttacact 3367021 gtcgatatag cctttcatat ccggcatgtc cagatcagca tggtctaaaa atgcggagcc 3367081 tgtctcagtc agcgaatacc ggtattgaaa gtagccgccc tttttttcct tcacctcatg 3367141 cagaaatcca aggttgcaca gctcttcaat ctggagcgtc agttcctctg aatatggtcc 3367201 gtaaaagtga aaatcatatt tctcatagaa aggaaactgc attttcttgg cgatataaat 3367261 cattttctgc agcttctttc gcccgatgat ttctccagaa tccgagaaca ccttcatcag 3367321 ttttgcatgt tctttcaaca aattcccgac atctcctttt tccttctttc caatttctat 3367381 gtcagtccca gcagctgccg gattttcatt ttcgcttccg gatgtttagt gccgtcacaa 3367441 atcaagtcct ttggatagta cagcttgtgg tccgtccgcc gtttacctga gatggattcc 3367501 acaatagccg actgtctgga cagctcttta atttggccgt tttgcgtcaa gagatggatc 3367561 ggcagacgct cctcttcctc tcctggtcgg taaaaatcgt atggcagatc tgatgaagaa 3367621 tcaacgacca aataatagct cggatcgatc cccgcctctt tgaacaatga agtcagctca 3367681 aaataagccg acatttcttc attcggattg aattcaacgt attggaaaag ctggcggtta 3367741 atgaatctgc ggcacaagtc ggataaaatc gcgtcttctt catcctccca ggcctggaag 3367801 taatacaaaa taatagattc atccagcttt acataatcct ccagtgtcaa ttttccttca 3367861 aaaatagaat agaaatgaac cggagcgtga gtgaagacat agccttcatc gtgcagctgc 3367921 ttcgccctgt gaagaatctt cgttaaaatg acctctgcac ttctagtcac aggatggaag 3367981 tagacctgcc agtacatttg gtaacggctc atgatatagt cttcgacagc gtgcattccg 3368041 ctttctttaa tgacgatctg atcctcgcgc ggccgcatca cccgaagaat ccgctccata 3368101 tcaaaatggc cgtagctgac gcccgtataa tatgcgtcgc gctggaggta atccatgcgg 3368161 tctgcgtcaa tctgactcga aatcaggctg accacttgct tgtttttata tgttttggca 3368221 atgacttcag caacatcctg agggaaaccc gggctcacct ttctgagcac ctgattaacc 3368281 tccgtgtctc ccaaaatgat acctcttgta aaatcctcgt ggtcaaggtg aaagaccttt 3368341 tcaaatgaat gcgagaacgg cccgtgcccg aggtcatgaa gcagcgccgc ggccaaacag 3368401 agttcgcgct cactgtcatc ccattcaggg cggcctttaa agacgtcatc aaccattctt 3368461 ctgacaattt catagacacc gagagaatgg ttgaaccggc tgtgctcagc cccatggaac 3368521 gtcaaatagg tcgttccgag ctgcttaatt ctgcggagac gctgaaattc acgggttccg 3368581 atcaaatccc atatcagctt gtcccgaaca tgaacatagc ggtgcaccgg atctttaaac 3368641 actttttctt ctgataattt tccatttgga tacgccatcg tcattccctc ttttttttag 3368701 ccgtgtttct attatatcga ctctattctt tgaaaacatc cttgaatttg cccggcgatt 3368761 tgttccatct tcatgaaaaa cacatcttgt gaagcaaaaa agcctgacct gagggccgag 3368821 gctaagaaaa aatatgtttt tactttttta ttttcttttt tactttgtca atcagctcat 3368881 cctctgtcgg agctgacagc gggcgattgt tcacaaaagc aaatgatttt ttccgtccgg 3368941 gcccgcaata agattggcat cctacctcaa cctttgcgtc cgggtccact tctttcaaac 3369001 gcggcagcaa tgttttgata ttagtggctt ggcaatcatc acacactcga aattcattag 3369061 ccatgacgta cgcttccctt catttctatg ttcatctatg tgaataacct aaaatcacgt 3369121 ttcaaaaaaa atcacatcac acttcatttt acaaggattc gactgttcct gcaagccgct 3369181 ccatccttcg tatctcctat tctttcagcc aatttgtata aatattttcc aacctggaca 3369241 ttctaatacc atgaaaagaa aaatgggagt tgagataaat gacaaaacag cgacaagacg 3369301 cttggtcaga ggaaaacgat ctgcttttag ccgaaacagt gcttcggcat gtgagggagg 3369361 gcagcactca gctgaacgcc tttgaagaag tcggcgataa attaaaccgg acatccgcag 3369421 cctgcggatt cagatggaac gcagtggtcc gccatcaata tgaaaaagcg cttcagcttg 3369481 cgaagaaaca acgaaaacag cggatgagag cgctcggaaa cgggcagccc gcgaaaaaaa 3369541 gattattata tcagcctcct gccgttgatc ctgaaatcat tcaagaaacc gctgcagaag 3369601 agccggttaa aacggaaaca ccatctgtcg aaaatgagca acctttaatg tctggcgaac 3369661 acatgccttt tgttgatgaa agctttaagg aagagttagc tagtctatca cacttattgt 3369721 ctcctcaaac gcctgcagct gcgcctgaga tgacgatgaa tgatgtgatc cgcttcctgc 3369781 agaattacga aggcaatcac gagcaatcat cagcattaaa aatggaaaac gagcgtttaa 3369841 agaaagaaaa tcaggaattg caaaacaaaa cagagcagct agaggcagaa gttcaaaagc 3369901 ttgaaaaaga ccaaaaaacg atccaagaag attatgaaac cttggtgaaa attatgaaca 3369961 gagccagaaa gctagtttta tttgaagaag atgaacatgc ctctccgtcc ttcaaaatgg 3370021 accggaacgg caatttagaa aaattagcgg aatgacatag aaaaatccca aaacgggcag 3370081 ctgttttggg attttcgcca tgtgcaaaat ccccttttct attgagaaaa gagaatttcc 3370141 tcattttgca gccggatcag ctattcttgt aaaatgaggc caagcttatg tgaatctatt 3370201 aagacatgtg agctgcctcg gccgtttttt gtttccgagg cgcagcagaa atgaccaaaa 3370261 gccccagcat cataagcgca atgcccagcc acgaggaagg cgaaagcatt tcccctatga 3370321 aaaacacgcc aagcaatgaa gccgtcagcg gttcagctaa agacagcgtg accgccgccg 3370381 aggccggaac cccggtaagc cctttcgcaa acaaaaagta tgcggcacat gttgcaatta 3370441 acccgatgta aaggcttgtt cccagtcctc taggggtcaa tatccacgag atatctaact 3370501 gccataatag cggcgtcagc aagatggcgc tgatcatgaa tacaacggcg gaggtcgctc 3370561 gcggaggctg ggttttcatc atcgctttac tgatgagcgt atagcctgca aaagaagcac 3370621 ccgctccaag cgccataaga acaccagcca catcaatccg aacattggaa ctgtcggaaa 3370681 acagaagcca gcaacccgct aaagccagca cagtcgcaat ccaccaggag tttcgcgggc 3370741 gtttcttcaa tacagcccat tcgagggtcc cggcaatgat aggcgcactg ccgatggcaa 3370801 tcacagttcc cactgcaatt cccgtttctt taaccgctgt gaaaaacagc ggctggtaac 3370861 acgccataca aacagcggct aaaaatacga gcggccatgc ccaatttttc acgtgaagct 3370921 cccggctgat ccaaaccgca agcagcatgg cgcttcctcc tattaataac ctgaacgctc 3370981 caaatgccag cggtgtggcg ctttctggag ccaatgcctg aacggttccc gtggtccccc 3371041 agaaaaaagc cgcaatcaat acaaaaaggc tgtaaatatt ccccttcatc tgcctctccc 3371101 ctttaatatg gatgctgatg tcattttatc gtttttcttt ttgtcgtggt tatctgtatg 3371161 taagaaggac ttatctgaaa ataagattat tgaggtaaaa tgccgcttga gataaaaaat 3371221 gcatgccggc atatacagcc ggcatgcgaa gaacgttcac ccaaatacct ttgcattccg 3371281 ctcagccatc cggacgaggt ttttctcaaa ttccatttcc tcatcaatgg acagtccagc 3371341 tgaataaaga tgggtgctta acgcttttaa ttccgtcaat aaagcgaaca ttaagtcttg 3371401 tacggagatg tctttttgaa gaagctcact taaggacgcc atcgtttccg gacgtatttc 3371461 cggatagacg ccttttttat cgttttgttt gtctttcagc gccgcttgat agaatcgtct 3371521 gatcaagtcg gccctttcac tgccgctttt atctgcacag agataaattt gaacagcgac 3371581 tccgccgcga acgcgtctct gagagatgcc ggcgaacttt ttgccattta tactgaggtc 3371641 atagctgccg ggacaataag acccttcaat ttcataggct tcgatctttg cgttgtacgg 3371701 tctcagcatt cgtctcatca gctcgaccat cgcttcatat cctttgtcta tatcgatgcc 3371761 tttcttttcg tcctcgaata tgagagagat atttaaaaca ccgtcatcca atacgacggc 3371821 aagaccgccg gaattgcgta cgatcacacg gtatccttcg ctctccagca aggagatacc 3371881 atcctgcaaa aacgggaggc gtgtatcctg tattccaagg acaattgtat cgtggtgcac 3371941 ccatgagcgc gctgtcgccg gcgacacgcc ttttccgacg gacatgcata gcgtatcatc 3372001 cattgcgaag gattgcttcg catcaaataa agggccgaga ctggattggt caatgactct 3372061 ccatttcggc tgcatcagta aatcaatcgg ttggtttgcc atctatgtaa aaccctttca 3372121 tgttaggctt attgaacgaa aactattata tcatttcagc agctgtgatt gataattgct 3372181 tttcagcatc gtaataaaaa tttctttatt ttttgtattc tccatgagag gagaatgaat 3372241 gtaagacagc ttgcgcttta acgagaaatt attaatatgc agaattgaaa tttcgcggtg 3372301 gatcaaatcc ttacgcagca cgcttctgga tagaaccgaa agtcccatgc cgttaatcac 3372361 cgcttccttt acaccttgat tgctgctgat ggtaaacatt gatttcggcc gaagtccatt 3372421 tgaactgagt acatgatcga gatattctct cgtcccggag cctttctctc ttgtcaccca 3372481 cgcttcgttc tgcaaatcgc tgatcgaaat ctctttccgc ccggcgagcg gatgctgatt 3372541 tggagcggca atgcacattt catcctccat gaacggttca atttccagct cattctcgtt 3372601 tgtatgtcct tcaatcagcc cgatatcagc ctgaagcatc cgcacacgct cgctgacctc 3372661 ctctgtattg ccaatcatga catctagatt cagctctgga tacagctttt gcagctgggc 3372721 caatagcggc ggaagaatat actcaccgat tgtaaagctt gcagctattt tcaattcacc 3372781 cttcacatag tgatgatgcg catagatttc agccttggct tgttcgtaga gaaacaccat 3372841 ttgctttgct ctttgatata aaatgtctcc tgtcggcgtt gtcgtaaagt gttttggcga 3372901 cctgttcaga agagccgttt gaaattcttt ctcaagattt ttgatatgca gactgacgct 3372961 gggctgggag atcatcagct tttccgccgc ttttgtgaag tttttttctt ctaccaccgc 3373021 tataaacgtt ttcagcacgt cgtaatacaa aaaccccacc cctgtcatta atgaaatata 3373081 tggttatgat tagttttctt tattgtactc atatcatccg tcttggtaaa gaagggctat 3373141 acagaagcgc aaaaaaggca gccctcggtc gagagctgcc attgtcttca attttattac 3373201 agtgcttgcg ccgctgtaat taatgcgaga ttgtaaacat cttcagcgtt acatcctctt 3373261 gaaaggtcgt ttacaggcat atttaaacct tgcaggattg gtcctaccgc ttcaaagttg 3373321 cccaaacgct gagcgatttt atagccgatg tttcctgctt caagacttgg gaatacgaat 3373381 acgttagcgt cccctttgat ctcggaatcc ggcgcttttt tctcagctac agatggaaca 3373441 aatgcagcat caaattggaa ttcgccgtca agtgtcagtt caggcgcttt ttctttcgcg 3373501 attttcactg catccgctac tttttctgtt tcatcagatt ttgctgagcc ttttgtagag 3373561 aagctgagca ttgccacgcg aggctcaatg tcgaacattt ttgccgtatt ggcactttcg 3373621 atcgcaatct cggcaagatc ttggctgtca ggtgcaatgt tgatcgcgca atctgcgaat 3373681 acgtattgct cttctccgcg agccatgatg aacacgcctg aagtcttttt cacgccttct 3373741 tttgttttga tgatttgaag agccgggcgg acagtgtcag cagttgagtg agcagctccg 3373801 cttacaagtc cgtctgcaag tcctttatac accagcattg taccgaagta gttctcgtct 3373861 aataatgctt tacgagcctg ttcttcagtc gctttgcctt tgcggcgttc tacgaatgct 3373921 tgtacaaggt cttccatgcc ttcatatgta tgaggatcat aaatcttaac gccgcccagc 3373981 gtaaggttca attcttttgc ttttgcttgg atctcatttt cattgccgat cacaatcgga 3374041 ttcagcactt tgtttcctgc aagcttgctg accgcttcta aaatacgctc gtctaagcct 3374101 tcaggaaata caattttaac gtcttttcca gctacttttt cttgcactgt tgaaaataaa 3374161 tctgccacaa taaaacctcc tcaaaaagtt acaaaaacgc tttcttttac tagcatactc 3374221 ttcttccaat caaattcaaa cagccaactt tcattatagc gctttcataa aaaaatctta 3374281 tttttctaac taatttaagt gactcaatct tcccttatag gttcttctat tttgatggag 3374341 ttatacggaa gggatgttca aggtttctcc acagtagaat cggataaact atggtatagt 3374401 gaaggcaatc atgaaaagat aatgggagtg aagataaatg agtgaacagc aaatgacgaa 3374461 tgaagcggca aaaacgcttg acggctggta tgcgcttcat gatttccgca caatggattg 3374521 ggcttcctgg aagcttctgt ccagtgatga gcgccaatct atcatacatg aattcaccgg 3374581 gttgcttgaa aaatggggcg tagcccaaaa agaaggaaaa ggatcgcaaa ctctttacag 3374641 catcgtcggc caaaaagctg attttatgct gatgatcctt cgtcctacaa tggaagaatt 3374701 aaatcaaatt gagcttgaat tcaacaaatc aagacttgct gagttcacca ttccggcata 3374761 ctcctacgta tcagtggtag agctgagcaa ctacttggca agcggtgacg gcgatcctta 3374821 tgaaaatccg catgtgcgcg ctcgccttta ccctgaactg ccggaatcta aatatgtatg 3374881 cttctatcca atggataaaa gaagatctgg caacgacaac tggtatatgc tttcaatgga 3374941 agaacgcaga aacttgatga gaagccacgg tttaatcggc cgcagctatg cgggcaaagt 3375001 caaacagatc atcaccggct ctgtcggctt tgacgattac gagtggggcg ttacattatt 3375061 tagcgatgat gtccttcaat tcaagaagct agtgtacgaa atgcgttttg acgaagtcag 3375121 cgctcgctat ggcgaatttg gttcattctt tgtcggcaat cacctttcgc ttgatacact 3375181 tcctcaattc ttatatgtat aatatccccg agctcgttta ttgagataag gactgatcgg 3375241 ccttctgctc aagtttgccg tactttttat atgcgaatac actgagcaca aatccgagga 3375301 ctgtgatggc ggcgcaaatc aatccgacag ctgcatagcc gtatgccaca tatacgggtc 3375361 ccattaaagc agaacctaat gtcacggcca gattcgaggc gagactgtaa aacaccatga 3375421 cttttcctcg atgacgctct gagcagtcac tcaaaatggt gctgagcagc gtcaccgtca 3375481 aactttgcat taatccccaa ataaataggc tggcgattaa cagaaacata gacgccggcg 3375541 catatggtaa acacgccagc agaacgctga tgacccccag cgcaatcaaa agggagcgca 3375601 tttttccgat gcggtcggct atctttcctg taatcacact catggaaaac ccgattccat 3375661 aaatcatgat aaataagccc gcagccgtgt ttcctccggt aaaaacgtcc tgaagatagg 3375721 tgcctaaaaa ggaatacata ccgtaaaaac caatcatatt acaaaaggtt attgtgatat 3375781 aaacaggtac acgagggact ttcagcgcat cccggaatgt tcctgcgggc tcttctattt 3375841 cttccttgcc gctgttttta tgttgggcat ggcggcgcat ttcaaggaga atcagcagaa 3375901 caactaaaac acccatcagg gcgaaaatcc aaaacgtcca tctccaatgc aggacgccgc 3375961 cgataaatga tccgagcggc actccgaaaa tcagcgccag cgaccagctt gaaacgatca 3376021 gtcccatcac cttgccccgg tatgtataag gaacacgatc accgacaact gcgtaagcgg 3376081 tcggaacaaa cgctcccgca gccaatcccg aaagcgcccg gcctaaaaag aagaaaaaaa 3376141 tattttgagc taaagcgcat atcaccgttc ctatgataaa aatcataagc ccggccaata 3376201 agctcagttc tctggagtat ttatcgccta atggaaccaa aagcggcgca ccgataaaaa 3376261 tcataacgcc gtaaatactg atagataacg caaggacgct gacatctgag ctgaaggctt 3376321 ttgctaaatc cggcagcagc ggtgagatca caagctcttc agatccggct gcaaataccc 3376381 ccatcgttaa agccagtgcc aacaataacg gaaaatgatg ttttgttttg atgtcattgt 3376441 tttgattgct gttcattctt tctcaaacac ctcttccata atcttcttat cataaagttg 3376501 tattatagtt tagcattgtt ttttctctat ttacaattcg aacgaaatat ttataagttt 3376561 tattattttc atttaaatcc cattatatat ttctatattt cattctaaaa atacatgagg 3376621 atgtaacacg taaaaaaagc tctccggcct cccggagagc tttttctatt gcgcctctgt 3376681 ctgctttttt tcaatcgttt catgatttat acgctttttg atgcttagat gatagtatgc 3376741 ataacagaaa ataatgatcg gcacaccgca gtataagcca attctttgat ccggaatgaa 3376801 aataaggctg atcaacacgc agccatataa acaaaatccg agaatcggga ctagcggata 3376861 aagcggcgtt ctgaactcca gatcattcac atttccgcct tctgccagga aacgcctgcg 3376921 aaagaaaaat tgcgacgcac aaatggacat ccacgcgaca actgtcacca tgcccgagat 3376981 tgagatacac cataaataca ctgtttctgc agccatgaca cttgtcagca gcgaacagcc 3377041 tgaaatgcct agcgtaatca gcagggcatt catcggcacg cctttttttg tcagtctggt 3377101 gagaaaggag ggacccattt gatttgatga aagtgaccac atcatacgcg acgccgcata 3377161 caatcccgaa ttagcaacag ataaaatggc cgttaagatg acaaagttca tgatatctgc 3377221 cgaaaatggg atgccgattt gatcgagtac tgctacaaac gggctttcaa tcacccccgc 3377281 cgttttgtac ggaaggatgg caaccaagac gaacatagcg agcacaaaga aaaacagcgt 3377341 gcgccaaata acatttcgaa tggactttgg cagtgttttt tccgggcttt cactttcccc 3377401 tgccgcaatg ccgacaagct ccgttccctg gaacgagaag tttaccatga ccagcgtaaa 3377461 cataacggcc agcaccccat tagggaaaag ccctctatca gtcataaagt tagacaaaaa 3377521 gggtgtctcc tgtccgcctt taaagtcaat caagccaaac acagcggctc cgccaatcac 3377581 aataaataat atgatcgccg ccactttgat gcttgaaaac caaaattcca tttccgcaaa 3377641 gcttctgaca gagagcgcat taatcaaaaa gatgacgatg ccgaacacga ggcaccatat 3377701 ccagatcgga acggagggca gccacctttg catcaaaatg cctgctgacg tcagctctaa 3377761 ccctactgta ttggcccagc tgaaccaata cagccagcca atcataaagc ctgtcgactg 3377821 tcccagaaat ttagtggcgt aggcctgaaa cgatccggcc accggcatgg caacagccaa 3377881 ttctcctaaa caaagcatga cgagatacat taaaaatccg ccgatgatat acgcggcaat 3377941 ggcgccgagc ggtcccgcct ggctaatggt aaagccagag cctagaaaca gcccagtgcc 3378001 aatcacccct cccaaagcaa tcataaacaa atgcctgctt ttcatgctgc gctgcaattc 3378061 atttttatga ttctgcatca tccttccccc tttggttctt ttgccgtgat ggtcatccgg 3378121 tagctttgca aaagatgaac ggtggtttgc tgtatgagga gaggcaatac atgaaatgtg 3378181 tacggtttat agactcgttc tgtccattta tggccgtctt ttccgtacac gcccatatta 3378241 atggatggaa tattcagctt gcgtatgtct ttgaacggaa tggtcccaat catattccac 3378301 ccagggaagt tcctgataaa agaatcaatt tcgccatcgg tttcgtgcag tgataaaaaa 3378361 ctgccgtctg ccaagtaggg gaaaaacttt ttgaagacaa atgtttcgcc tgtcgattca 3378421 gcggttttgt cagccgcttc tttaatcaca tgctgcaaaa gctgatctct tgcgctatct 3378481 tctttcaaat agttatgcgg caggtaagga ggtgcgtaaa atagaatgac ttttgcgcct 3378541 tgatcggggt caagcttttg aagctcttcg attgcctgaa agcatctcat gcgaagttca 3378601 aggtgctcgt tggctttgaa tgtctgctcg atacactgct cgggatctat tccccggttt 3378661 ctcagctttt ctaagtattg ctccaggcta tacacttgaa tgccccatga taaatgtttc 3378721 tttggcaggt tggctctttt tacatattct tcgtaataat ctgataattt ttgttctgtc 3378781 tcccggcatg cttcctcagt gacttcaata agcaaatcca tcatttcttt tgctgttctt 3378841 tcataaataa aacaattgaa atacaagctg gtgctgacag ccgtttgcac attataggat 3378901 tccttgttat cacgctgata caaacaggat gggggcagaa ccaactcccc ttcaaccttt 3378961 tctgccagat ggatgttatt gtggagacgg cttgtgattt cagatgaaat gaaatttggg 3379021 tcaatccctg ccagtgtatc gccaacatgg acttcacgcc cgtaaatgta aaagcaaggc 3379081 aacagttttc ccgcggctcc ggtatagata tatcttgtct gatcaccatc gtaaagcggg 3379141 gtaataaaat ccgtattaat agcagccaaa tagtgaagct gtttttcttt ttttagccgg 3379201 ttcagctctg aaatgctggc gagaatgccc gaatgctggc tctcctcatc gggattggcc 3379261 ataaacaata catttcccgg caacgtctca aggttctccg aaaaatgcag gagattggct 3379321 aaatgcacgg cgatgccgct ttgcatatcg acagatcctc ttccgaacat ccactcgcct 3379381 gatttggcat cccgctgaac atcctgatcg aactcatagc ggctgaaata ctcggccaat 3379441 ttctcacaat caaaagcgat atcctttaaa gggccgaaat cttcaattcc aactgtatcc 3379501 agatgggcat ggtaaatgac tgtatttcgg ctttctccat gtcctttaat aaacgcaaaa 3379561 atatttttgc gtttgtatgg gtcattggga atggcctgtt cccacacatg actggggttt 3379621 tcctgaaaat aaggatagct cgtgatcact tctttgatga aatctgcttt tgtcccttct 3379681 ccaacggtgc cgttcacgct gctgaggctg accagagatg ctgtcagcgc ctccactctt 3379741 tcagccggat tcatgtgact gatttttgta tactgcataa attgtcctcc tgatcaaaaa 3379801 gttgaaatcg tgcgatccgc taaagaatcg cacgatttta tttctctcaa atcaaaaagc 3379861 ttcggacgtt gttttggctt gcatatgaag aattaagtaa tcgggaccgc ctgcttttga 3379921 gtctgttcct gacatattaa aaccgccgaa cggctgatag ccgacaattg ctccggtaca 3379981 tcctctgtta aaatataggt ttccgacatg gaaatcctcg cgcgcccgtt caatgtgcgc 3380041 acggtttttc gtcagaagcg cacctgttaa tccgtattcc gtgttattgg caatctccag 3380101 catatgatcg aaatcacgcg ctttgcaaat cgcaacaacc gggccgaaaa tttcttcctg 3380161 catcaagcgg gcgttttcat caacatctgc aaagatcgtc ggctgaataa agtagccttt 3380221 tgaatcatcg ccttctccgc cggccaatag cttgccttca gatttgccga tttcaatgta 3380281 tttcatcact ttgttgtagg atgcttcatg aatcacggga cccatatacg tatcaggatc 3380341 ttctggattg ccgacagtca gcgttttggt cagcgccaca gctttttcca ccacttcatc 3380401 atacacatcc tgatgaatga ccgcgcggga gcccgcagaa cacttctgtc ctgaatatcc 3380461 aaatgctgaa tacacgatag aggatgcagc aaggtcaaga tcagcgtcct tgtcgacaag 3380521 cactgtgtct tttccgccca tttctgcaat tacccgtttg agccattttt ggcccggctg 3380581 cactttggca gctcgctcat aaatccggca gccgactgca cgggaacctg taaatgagac 3380641 aaaccgtgtc ttcggatgct caactaagaa atcaccgatc tccgcaccat ctcccggaat 3380701 gtaattcaga acgccgtttg gcagacccgc ttcctccatg acctcgacaa attttgctgc 3380761 cactaccggg gctgcgtcag ccggttttaa gagaatcgta tttcctgtca caatcgctgc 3380821 caccgctgtt cccgccataa tcgcgagcgg gaagttaaat ggagaaatga cgatgccgac 3380881 gccaagcgct tcgtaatgat attgattgac ctcgccagca cggctcttca ccggagcccc 3380941 ttccttgagc tttaacattt ggcgcgcgta gaactctaaa aagtctatcg cttcagccgt 3381001 gtccgcatct gcttccttcc acggttttcc tgcttccttc acaagatagc ttgaaaattc 3381061 atgctttctt ctgcgcaaaa tagccgctgc cttaaagaga atatttgcgc ggtgctccgg 3381121 tctttgtttt ttccaggaat caaatgcctg caatgcggct tgcatcgctt tttcagcaag 3381181 ctcttgatcc gctgtagacg cgtacccaat gatctcttct ttatttgccg ggttaataga 3381241 aatgattttg cggtccgttt caattttttc tccatttatg acaagcggat aatgcttgcc 3381301 gagctgagtg tttacaaagg ccaatgactc cccaaatgca gttttattct ttgcttccgt 3381361 aaaatcggta aatggttcgt gcgcgtatgt gactgtcata tgtagtcccc ctcgtgttat 3381421 gaaatatatc ttcgcatatg aataaaaatg caagaatcat gccattttct tgtcttttgc 3381481 tgaaaaaact tgttgaatcg aacagaaatt tgtctaacag gtgatcacct ttctcttttt 3381541 ccgatcttga acgcaaattt attttgcgtt ttttgctctt tacgcaaaaa acaaatgcaa 3381601 aattattttg cggaggcttc tcaaattaga cccatccgcg gaaacgcgat gcttctgccg 3381661 attttctgat gcccgtcatg taagccgcca aacgcatatc cactttatgt gttgccgctg 3381721 tttgataaat tgtttcgaac gagctgacca tgacgcttct cagtttttct gcaacctctt 3381781 cttccgacca ataatatcct tggttgtttt gcacccattc aaaataagaa accgtgacgc 3381841 cgccggcact cgctaggata tccggcacaa gcagcacgcc tctttcattc aggatcttag 3381901 tggcatcaat ggttgtcggg ccgttcgccg cttcaacgac gattgacgcc tgaatgttat 3381961 gtgcgttttt ggctgtgatt tgattggaga tcgcggcagg cactaaaata tcgcaatcct 3382021 tttcaagcag ctcctcattt gtgatgacgt cagtaaataa attggtgacc ataccaaagc 3382081 tgtcccgttt atcgagcaaa taagggatat caaggccgtc tgggttgtag agcccgccat 3382141 tggcatcaga aatcccgatc accttcgcgc ccgcatcgtg catgaatttg gccaggaagc 3382201 tacccgcgtt tccaaagccc tgtatgatga tgcgcgcgtt ttgcagcttg atcccttttt 3382261 tcttcaccgc ctcttcaata caaatcgtga cgccctgtgc cgtcgctgtt tcccgtcctt 3382321 gcgatcctcc caaaacaagc ggtttacctg taataaagcc cggagaatcg aattcccgca 3382381 gccggctgta ctcatccatc atccacgcca taatctgcga attggtgtac acatcgggag 3382441 ctggaatatc ctttgtcgga ccgacgatct ggctgatggc acggacatac cccctgctca 3382501 gcctttccag ttctccaaat gacattgtcc gcggatcaca aataataccg cccttcccgc 3382561 cgccgtaagg aagattggca atcccgcatt tgagcgtcat ccaaatggat aatgccttta 3382621 cttcctcttc attaacttct ggatggaagc gaacgccccc ctttgtcgga ccgacagcat 3382681 cattgtgctg tgaccggtag cctgtgaaca ctttgacgct cccattgtcc attttgaccg 3382741 gaatgcggac agtgagcatt ctctgcggct ctttcatgag ttcatacata tctcccggat 3382801 aacccagctt ccgaagggct tccttaatga ttgtttgggt agacagaaat aagttaagag 3382861 cttctttttc ttcatctttc gagacttgct ttgctgacat ctttttcacc tcattgtttt 3382921 tttggccggc tgtaatgtaa gcgctttaaa aaatcagccc gccaattcct ttcttcattg 3382981 gattcaccct tatcatcatg caagatccgt accagctttt gaatccacaa aaaaagagac 3383041 tgaaaacatc tcagtctctg actacaaatc tatcgattaa cggggatcaa tcaccagctg 3383101 cgtttcagca taaaaactgc cgattcccaa accgtttact acatcgcctt taatcgtgta 3383161 agtgcctgcg cgaggaagag ttttacgcac catgacaagg tcaaattcgg atgcgcctaa 3383221 caaatcaagc gtaagcggga gtctgactgt ttttccatcg tttaaaatct gtgtttcttt 3383281 cagtgttctt ccattcactg aatctcttgt cgtagcatga aacccgtcag gaaattgaaa 3383341 ttctaccgct ccaagagaaa gcaccgcatt tggtttatat gtcacttcaa tatcagaaat 3383401 ggtccactct ttcgtgctgt taactgtttt tgcctcgatt gatgcagact gtgcatgagc 3383461 ttggcccgaa ggaagtaaga ttgatagtaa aacagctgaa ctgatgaata atgaagatac 3383521 gaatgaagtt ctttttagca tgacatttcc ccctaattga ttgttgaaat ttggccagag 3383581 cgtcctctgc agaaaaagcg ctttttcata attcgcgaat taccagttct ttttcttaaa 3383641 aattaatcta tcatcatttt ccatggaagt aaatgttttt taaggaatat taacacttgg 3383701 aattcaatga gaattccttc ctgtttatac aaggttcaaa tggacgattt ccctctcttt 3383761 ttctagtaac atctgcctga cattttatat cttttatcct attttaaaaa agggcaaaaa 3383821 aagtcgaaga tgcctctgct cttcgattga tcacgttcct atttttatct gaattcagtg 3383881 ttccagttaa aaccgatcgt ctcatcatcc cacggaattc ttttttcatc aggctgatcc 3383941 gggttatacg acatggtggt aaaatagata attgtcagcg gcgtctctcc cagcactcta 3384001 tatccgtgag ccaccccttt tgggattaat aacagcatcg ggttgtcttc gcccatataa 3384061 tagacgtccg tttctccttt tgtctttgaa tcctctcgaa gatcgtatag gacaacctga 3384121 gcgtggccgg ttgggaagaa ccagagatca tcctgcttct catgataatg aaatgcctta 3384181 atcacacccg gatagctttt cgaccaagag gcctgcccaa aatgctcaag gagattctca 3384241 tcgtcccgga ccagctcagc aaaaaagcct ctgtcatcgc tatgcttcat caattttttc 3384301 accttgactc catcaatcac acgcactgct cctttcctgc aaatactctc gtaacgcttc 3384361 ccgccagtgg cgggggcgga tgccggcttc ttcaatagcc cgatggctca gcacagagta 3384421 tgccggacgg ggcgttttgt tcccgtattc ctctgtcgtt acagacaaaa tggctgtttc 3384481 cagcccgctt tcttccataa ttgccgtcgc aaactcatac cagctgcata tgcctgaatt 3384541 gctgacatga tagatgcccg gcggatggct gaacagcttg atgaccgctt ctgctaaatc 3384601 cttcgtataa gtcggcgaac caatttgatc gctgacaacc cgaagctctt gtttcgtttc 3384661 agcaagtttc agcatggttt caacgaaatt actgccgcca tgtccgtaca cccacgatgt 3384721 cctgatgatc gtgctgtctt ttgtcgttaa tcgtatcagt tcttctccga gccttttgct 3384781 tttgccataa atggttttcg gatcgagggg atcgtcttcc ctatatggct gggttccttt 3384841 cccattgaat acatagtccg tgctgatatg aacatattga gctccgatgc gggttgactc 3384901 aagcgctgta taataagcgc cgattccgtt aatcaagtac gctttatcaa gctctttctc 3384961 gcattgatca accgacgtaa acgcggcgct attgaccacg atatccggct gataatggcc 3385021 aaacgaatgc cgtactgagc gctggtcagc aatgttcatc atcttctttg ttaacgcaat 3385081 gacctcatat ccggcttgct tcagctggcg gcatagttcc aagccaagct gtcctcccgc 3385141 cccagtcacc aatacctttg tcaatcagat caccttctca tcggtcattg tctgtatacc 3385201 actgaatcgt acgcgcaatg ccttcttcaa acgtcacttc ctgccgccag cccagttcgt 3385261 ttttcagctt tgatgcattg atcgcatagc gccggtcatg cccttttcgg tcttccacgt 3385321 gggcgaacaa ttcctcacag cccagatgct tcaaaatgac actcgccagc tctttattcg 3385381 tgcgttcatt tccgccgccg atgttataca cctcgccgtc ggtccctttt tctaaaatca 3385441 gcttgatcgc gcggcaatga tcctccgcaa acagccagtc tcggatctgg agtccatcgc 3385501 catacagcgg aacaggcagg ccctgcttcg catgacggat aatcgtcgga atcatttttt 3385561 cgctgtgctg ataaggtccg taattgttgc tgcatcgtgt aatgatggcc ggaagcttgt 3385621 gggttttcac ataagacaac acgagcaaat cagagcttgc tttgctggct gagtatgggt 3385681 tattaggaga aagcggcgtc gtttctgtaa acgcgggatc atccgctttt aaatccccgt 3385741 atacctcatc tgttgaaata tgaatcagct tcttggcttt tcctttcaag accgcttccg 3385801 ccaatcggta tgtccccatg acatttgtgg tgataaacgg ctccgcttgg gaaatgcttc 3385861 tgtccacatg cgattctgct gcgaagtgaa tgacgccatc gtaggtctcg tcaaaagcgc 3385921 ggtcgatatc ctcctgaacg ctgatgtccc cttttacaaa gcgaaaacgg ctgttttgct 3385981 ttaatttttc catttcctcc gggtggctgg cgtacgtcag tttatctaaa acggtaatgc 3386041 gcgcatccgt ttccctcagc atgagctttg taaacgtgag cccgatgaag ccggccccgc 3386101 ctgtaattaa atatgatttt gccatcactt ttcgtcctgt cctttccgta aagcctggtg 3386161 tacaagctgg gaagcgagat aaagcgattc gtgagttccg gcatctaccc accagcctga 3386221 taacacatca tacgtaagct ggctgttttc gatgtataga ttattcacat cggtgatttc 3386281 cagctcgccg cgctttgatg gtgatatttg ttcaatatat gaaaacacct ctgcatcata 3386341 catataaatg ccggtaacac aaaggttggt cggtggctgt tcgggctttt cgatgatgga 3386401 acgaatccgc ttgtttttct catcaatctc agcaatcccg aaacgttccg ggtcatcaac 3386461 ttctttcaga agcacttttg ctcctttccc ctgctgttca aagcgttctg tataaggctt 3386521 taatgaatct tcaaatatat tatcacctaa taataaaatg aaagactctt ttttcgtaaa 3386581 gcgctttgca taagacagcc catccgaaat gcccgatgct gccggctgta cttgataagt 3386641 gatagtaacg ccaagctctt ccccgttccc aagcagtttg taaaattgcg gcatatgctc 3386701 cttttggctg atgagtaaaa tgtcttttat tccggcttcc tgcagcttca taatcgacca 3386761 gtatatcatc ggatacgggc ctacaggaag caaatgcttg ttgacggctt tcgttaaggg 3386821 cataaggcgt gagccgtttc ctccggctaa aataacacct ttcacattaa cacttcctta 3386881 catgcatttt tatatctctt gttcatataa atcttgaaga atagctgtta cccgtataat 3386941 gcctttgcca tccacgagcg gccttcctcc cttgtgcaaa gaaaggcgaa gaggatagct 3387001 gctcataatg cgtgacatct gatagatgag tgtttcatcc ggtacaagct cacccaatcc 3387061 aagatcaaga gcggcgcctt ggtcagcaaa tgttttggct gtagccgttt gatgctcaac 3387121 ctgagaaaga acaaggcacg gcacgccgat gcaaatggct tcatatagag agatgccgcc 3387181 agcgacaatg gctgcgtccg cttgtttcat caaacctgcc atatcatttg tctgttcgat 3387241 catcttgtac tgcggcttct tttcgatccg ccttcggact gcctcttgat gcggtgaagc 3387301 gctccccatc acaaacatca tgtttttgtc ttttatgtcg gggacttgat cagcggcagc 3387361 cagcacttta aaaataagct gcttcggatc acttcctcct aatgcaacaa ggatattgcg 3387421 gcagtctttc ttaagtgtgt aatcctctct tgcggcctga aaggcggggt gaagaataag 3387481 atagtccgga ccttcataga tgcgtgtgtt tccctgaacg tacaccctgc ttctgatgtc 3387541 accgtaaatt ccgttaatga ctgcgtcact atattgaatc gatttaccgt ttttctcttc 3387601 aaaaagaaca attttcgcat ctgtctccgt ctttattttc tttaacagct ctgcaggcgc 3387661 gcctagaata tcaaacaaaa gcaaatcaag cttcttgctt tttatttccc ggagaataaa 3387721 ttcgtgctgc tgcagctccg gctttacgat gacctgccaa tgctcttcat gaagaaacgc 3387781 ttcagaatcc tgattcgtat aaaacgtaat caagcatcgc tgtttgagcc cctccgcaag 3387841 cctcttcatc cggacaacat ggcccattcc cttttcatag ccgccgtctg cgaagatccc 3387901 aacatgcatg gctagtcagc ctctcgttcg gttgccgcat cggggttccg gttcagaagg 3387961 gtgataagct ctgaggcgga tacatcgggg cgctcgcctg ctttttgata gagggccttt 3388021 atcgattcat agtcttcctt tgtatcaatg gtcagccgat attgaggggc gcgaaatcgt 3388081 tccggcgcct ctaaaaactg aacacgataa agagctggat gattccttat atataacgtg 3388141 acatgctcct gatattgatc ctccaaagcc tgaatacggc tgatgtcaat taacaggttg 3388201 gcgttgacca cttcgccgca aatccctaat ggggcattca ggatatacgt ataatccgag 3388261 ccttgatcaa aatgcgcctg aatcattaca tcgagcagct caggatcgac aaacggatta 3388321 tcacctgtta accggatgat gactgacggt ttaacagctt ctatgacctt cacaaaccta 3388381 tcgaggacac gttcttcgct cccgcggaaa acacgaaagc cttgtttgat acagtgcgcc 3388441 tctaatatgt cgtcagtttc tttgtcagac gtggcgatga caagattatc ccgatccttt 3388501 tggtaaaacg cgctttgccg gacacggtga acgagaatat caagtaaacg attcgatccg 3388561 agcggccgaa gcacttttcc cggaagcctt gttgaaccca ttcttgcttg aatgataaag 3388621 agaatatcat tcatgaaacg ggctgtcctt cagtaaaatg tcatcccaga caatgcctgt 3388681 gtcggctgga atgtctctta cagcccgaac accgctggtc agcagttcaa aaaatctcgg 3388741 gtgcagcccc tgcggctttt gtccgggccg aagcactgcg atattgtctt cactaaaggc 3388801 ttcacctttt tgaatcggag ctgttgtaaa aatgcctctg tatgcaaagt ttctgatttc 3388861 tccttcgatg gcggtcgttg ttttgtatga actgccaagc agtttttcag agaccggctt 3388921 tgtgatcccc tgtttcagct cagcttccgt tttcctgatg ccatcgacca tttctttcaa 3388981 ttcatccgga tttaatgcaa acgagtggtc agcacccggc agatttttat cgatcgtaaa 3389041 atgcttttct atcagttttg ctccgagccg aaccgcggca cacggcgctt ctgtcggatg 3389101 ctcgctatga tcggagaagc cgattaccgc ctcaggaaaa gcggcggcaa gcatcggaat 3389161 gacgctgagg ttgctgtact ccggcggtgc tgggtatttc gccacacaat gcattatggc 3389221 aatttgattg tttccctctg ccctgatggt gcgccaagct tcgtgaacat cagagatttc 3389281 agctccggct gtcgagaaaa tcatcggcct gttcagccgg gcgacatatt taagcagcgg 3389341 gagatggtta atttcatagg atgcgatttt aaaagcgctc ggcgaggtag actgaagcag 3389401 atcagctgac ccctcgtcac ataccgtact taaaaagatc acctgctttt cgcggcagta 3389461 atccaatagc ggtaaaatcc actcagcagg catttccata gattgaacca aagaaaaaat 3389521 agagacgtcc ttgcccgctg ccgtcttgta caaaccagga tctttctggt acatcctatc 3389581 agcttggaac atttgaaatt tcacggcatc cgctcccgct tccgccgcgg cgtctatcag 3389641 cgcaaaagcc tgatcaagct tcccgtcatg attaatcccc gcctcagcaa taataaaaac 3389701 aggagcgtct ttgcctacag ttttattcgc gatctgaaac gctgccatta tttcgcctcc 3389761 ttgcccggcc aaatatgata atagtaatac gattgttcag cggtgaagcc cattcgttca 3389821 taaaggcgga tcgcccttac attgtgaagc tgcgtccccg ctgttaccgt tctatgcttc 3389881 tgggtctccg gttgttctat gagattcgcc aataaatgaa acgcaatacg tttcccttca 3389941 aatcccggct ttacagccat caaatcgaga atgcactcat catctcttga taagccctga 3390001 agatagccga tgacctcgcc attgtgttta gcgacaatat tgaccgccgc ccttccattc 3390061 agattgtttc gtgtccactc ctgaaatatt tcgtttgctg catcgcggct gagatgagga 3390121 tcctgaaaat atctgctttt tgtaaacgag tctcgggcca gctcacatat cgcttctgtg 3390181 tctccgggct caggcgggcc cagttcaaaa aatggcggtg ttttgtcata aaaagacgga 3390241 ggcatcgcca gcttcagcaa actcccgaca aagtaagagg atggctgctg ttgtatcaca 3390301 tgcgcggctc cgatatcttc agccggaaca cggacaaaga taaaatccgt ttcatccatt 3390361 tggcgtacag tataaaaagc ttcaaacagc ctctttagct gcccggtact atttgccgca 3390421 agaagtttga cgttcatgac tttcttctga agcaccttgc tttcccacaa agaatcttcg 3390481 taaagcaata cgccttggag cctgctgttt tcaaaaaggc cgagggaaaa ttgatacgga 3390541 acatccaatg taagctttct gctttggaga aattcctcaa ttgcctcttt ggagacattt 3390601 tcttttaccg tatacactta atcagcccct tttacgatat cccgcacagc ttcaatgaca 3390661 tcatctacat catcgtcaga cattgatgga tagagcggga gagaaagggt tcgtttatag 3390721 taattcatgg cattcggaaa gtccgcttcc ttatatccaa attgcttttg ataatacgga 3390781 tgaatgtgta ctggaataaa atgaacgcta gtgccgatat tgtattcatc ctttaaagcc 3390841 gtaatcattt cgctgcgcgt aaccccggcc tttttttcat caacttgcag aacatataga 3390901 tgccaggcgt gcctgccgtc atcatggaca aacggcgtga tcagcccagg aatctgctga 3390961 aaagcggttt gatagcggcc ggcaatctct tctctccgtt tctgcatatc atccagccgt 3391021 ttcagctgat gaagtccgag ggccgcctgc aaatcaaaca tattcatctt atagccgggc 3391081 gattcgactt catagtacca gctgccattt gaagaataac ggttccatgc ggctttactc 3391141 atgccgtgaa ggcttagcac ccgtatctta tcggcaagct cctcatcatc agtcgtcagc 3391201 atgccgcctt cccctgtcgc gaggtttttg gtggcgtaaa agctgaatgc cgttgcatcc 3391261 ccgatagaac cgatcattct ttgcttataa gtcgtatata ccgcatgtgc cgcatcctcc 3391321 agcacgaata aaccatgatt ttgggcaaca gccaatattg catccatatc gcaggactgc 3391381 ccgccaaagt ggacgggcac aactgctttc gttcgcggtg tgacggccgc ctcaagcttt 3391441 accgggtcaa tattgagcgt gttttcgtca atatccgcaa acacaggcgt cgctcccgta 3391501 tgaataatcg tattggcggt cgagctgaac gtaagcggag aggtaatgac ctcgtccccg 3391561 ggcccaatcc cttttgcttt caaagccaaa aataaagctg cggtacatga attcaccgcc 3391621 acggcgtgct tcgccccgac aaacgcggca aactcttttt caaactgctg aaccttcggg 3391681 cctttagaga gccatcccga ttcaagcgtt tctgtaacct cctgaatttc ttccttaccg 3391741 attaacggca atgagtaagg gagaaaatga tttctctttt gcaccatttc tttgcgctcc 3391801 tatcatttta ttcagtatct tcccgcctgt aatcaacccc tgttttggct ttcagttccg 3391861 caaataaagc atttgttgat tctgccaccg gataattagc cgctatgaat gccaggcgcg 3391921 cctcttctgc tttttgatgc acgtcgggac ttcgaagaac ctcaaccaag gtgtgcgcca 3391981 gttcatccgg ctggtcaaac ataaaatcgc caagagactc ataatacgga tacgagcgat 3392041 ttccggacga ttttcctatc agcacaggct tttgaaacag catggcttca agaccgactg 3392101 tcgaggtttg cgtcactgcg gcatcaacat acggcagcaa atcataaagc tccagctcct 3392161 ttttgatgac tctgcatgct tgatgttttt tcgccgcctc gtgatacaga tcaagcttgt 3392221 tttttccgat ttcccacggg tggggtttga taatgatttg cagctgcttc tgatcagaaa 3392281 gcccctgcag cacaccggaa taaaagtctt ctgaaaaggg ctgagtggca atgagcacaa 3392341 tttttttagt cggctgaaaa gcaagttttc gatagaatat ggacatatcc ataggcgttc 3392401 tgttaaaaat ctgatcgaag cggggatgtc ccgttacgag aatctgctcg ggtttacagc 3392461 cttttcgtat gaaccactct gcttcatacg caccaaaaac agcttgatag gttgtaaaaa 3392521 caggaatgaa ggcttcatct cccatcaatg cgccatgctg aagacaaatg ctgacggccc 3392581 cttttctttg acacatgaga gcgagcaccc tgctgtaaat gtcttctgcc gttccgacaa 3392641 taacagctga aatcttttcc tgttcaaaca gcgcatcaac tgtatcaatg gcctctataa 3392701 ataaaggaat atctttgaaa agccggtcgc gaaacgcttg atcaccaaat gccgggtgat 3392761 catcataagg ggcgagaagc gaacaggctg tttcgagata ctgcttcgaa tcgccttttt 3392821 ggcatgaatc cgcaatctcc cgcttgctaa ttacaggcag atcacaataa tgcggcaaac 3392881 tccatctggc caaaacagcc gttttttcag gatcaaattg atagtaattt tcgtttgaaa 3392941 aacgcaggta atcaaagtgc aaaatgactt tccctttaac aggttcgtca tttgttttaa 3393001 cgatgttttg gattctttct tcaaaaaacg gctgaatctg tccctcatcg atatgctgat 3393061 ccaccgatcc gaataattcc ggttcttctt ccatcatcac cctcagttca gggctgatgt 3393121 attgataaaa attactgata agcccaagcg gaatcccttt gtagcgaagt ttgtcaaaaa 3393181 gctccacgta cttccggtac agcacccaat aattgcttaa ataggccgac aagctctcac 3393241 cccattccaa gcttttttaa tgattcacgc agctctcggc aatttcgctg cggaggaagg 3393301 ttcctgacaa attcattttt ttctaattca aacagctgaa agtgaatcga ttggtcggta 3393361 atataattca ggtccagctc ctcatccagt gggtaaaacg gataaaaatg attgactctc 3393421 caaaagaacc gggcatctcc tatacggtaa aacgccgggc tttcatccca ataggagcca 3393481 aacttctcct ttaccttctc aagcaccgaa tacctgtgca tcaccgagca atgatcaatt 3393541 gcgcacggcg cgttccatgt cacttgagcg gcaggcctga cagtttcttt tacaatgtca 3393601 cgattctcgt ttaaatgata ggttttggag gctgagtaaa tcacagcctt ttcaggatgg 3393661 gtatcgagct cccgcaccat tttcaggagg cggtccggca tatagatgtt gtcatccgtc 3393721 gcataggtga tatattcacc ctccgccatc tcaatcgcct gattgatcag tgccgcgtat 3393781 ctcgtttttt ctgttctttc cttcactcca gatatatcgc tttgataaaa acgcactcgg 3393841 ttatcattca aaaaaggacg gattacattc agcgtctctt cattggagtt gtcatccata 3393901 ataaacaatt caaaatctga aaacgtttgt gagagtatgc tagaaatgga ctttgccaca 3393961 taatcgcttt tgttatagct cgtcataatg actgatactt taggcaaatc ctacacctcc 3394021 ttcttggaac ttcacacctg aaactatcgt tatcttatgt tgcttatgct caagttgcgc 3394081 tagggataca aaccaatatg cgaaaagttt gtgtatgttt ctgaaaaaca gcggctgccc 3394141 agagcgaaat ctgatcggtc cgctgttctt tttcagcata atccaagcat cagcctcata 3394201 aggtgaaaga gataaaaatc gcaccagcga ctaagatcgt tttccatcgg aggtgagtca 3394261 tcgcggagcg ttcacctata catccagaac atgttttgaa tggttttcat aaaaaggagg 3394321 aacgatatga aaccgaaaaa aaatcaatat cagcaaatgc aggcatttga taatatgcag 3394381 gggtatcagc ctcagtttgg cgccaacccg tacccgcagc aaggccaagg ctcacaaatg 3394441 cagacaatgg ggatgcagcc aatgatgcca atgcagcagg gacagcaagg acaacaagga 3394501 cagcagggat ttggattccc gggccagcag cagggcggcg gttttcaaat tccatcgggg 3394561 cctacaccgt caggaccggg ccaaagcgtt cccggcatgc tgcctgttga ggaatcttac 3394621 atcgagaata ttttgcgcct gaatcgggga aaaacggcca ccatttatat gacatttgaa 3394681 aacagcaagg aatggggctc gaagattttt cgcggcgtca tcgaagctgc gggccgggat 3394741 cacattatta tcagcgaccc gaaatcagga acacgctacc tgctcctgac aatctacctc 3394801 gattacatta catttgatga agaaattgct tatacgtatc catattccat ggcgtcctat 3394861 tcgccaagat aagaaaaaag ccaatcactc atatgatgag gattggcttt tttgtttata 3394921 gatatttgac ggctgcgaca acgatcataa tccaagaaat aataaacgcc acaccgccga 3394981 gcggggtgat cgctccaaga atggagattt gcgtcacact tagaatatat aagcttccgg 3395041 aaaacagcac aattcccgca aacatcagcc agccggctgt cgtgacactg cctatgccgg 3395101 ataatttatc agccagaaac gcgacaacga ataacccaag ggcgtgatac atatgatact 3395161 gcacgcctgt gtgccaaacc tgaagatact tatcaggtat tttcccttct aatccgtgag 3395221 cgccgaatgc tccgagtccc acggcaagca gggcgttaat ggcccctaat atgataaaaa 3395281 ctttcatcta tctctcccgc cttttcgtta aactcatatc atttatctta tcgcacctgc 3395341 accaaaattc aatgtttgtt ctccgttgac acgagattgt cggattttct cctgcgccaa 3395401 agctggaact ggtcagctgc tattgcagca agcgtcccta atacgagccc gttgcttaat 3395461 agagaaataa ataccggatg caatcccttt aacgcagttt caggaacaaa catgataccg 3395521 acccctgtca gcagtgagat accgatgata gacctcaccc tttttgattc ttctttctca 3395581 tatgaatcaa attcggcaaa ggccagaccg cccattgcgg agaacacaac aaaattcacc 3395641 gcaaatccaa cgggtgacgg caggctcgca aacgtattca taaaaaacgg gatcacgctg 3395701 atcacgataa ccagaatact gccgagcata aacggttttt tagaaggcat cttggtcgtt 3395761 tcaataaaac ctgcggctcc cgaaatcgga acaggcgcaa tagctcccgt caaaccgcta 3395821 agcagatggc tgaatgaagc tgcaaaaccg gcatggcgtt catgatgctt tccatcaggc 3395881 tgtttgctga attttttcat ggcgatgtcc acgaccttca tgctcgccag catattcacg 3395941 atcagcaaga tggtaataaa aatagaagtg atgatcaggc cgctgttaaa taacggggtc 3396001 ccaaaaggaa acagggaagg cagctgaaac agccggtccg gcatttcaat cggctttgcg 3396061 gctccggcag ccgcaaacag cacccacccg ccgaacaagg ctaataaaat agaatattgc 3396121 ttaaaaaaca tgatgttcga atttgtcatt ataaaagcgg cagcgatcac aacaagcgcc 3396181 aggccaaata caagaccgtc caccccgtcc tgtcgataac cgattccgag aattcctttt 3396241 ataatgggct gactcagctg catgacaaga agcaataaat agacgcccgt tacaaccgga 3396301 gtaaacaatt ttgcaagtct gtcaatgacc ttgaaaacac ttaacaaaaa gaaacataca 3396361 gcgcttacaa gaagagctcc ctgcaaaccc cgcagtgtgt ctccatatgt cgcaaacaca 3396421 gttcccgtca gccctgcgta aatcgtatac actccccacc acaagccggc tgggctttca 3396481 ttgatcggca gtctgtggcc tttcaaacac tgaatgacgg cggcaattcc cagtacaaaa 3396541 aaagtgcttt gaatcaatct tgcagaatct gagtgatcca gatgaaacga ctgggcaacc 3396601 gccaccggaa caacaatcgc cgcagcaata ataaacgctg tccattgcag cgcgccaaga 3396661 accaatttca cgtaagctca acctctctct ttaaaaatca aataaagact ctccgtttcc 3396721 atcctcttcc tgcttctctt tttcttgctt tcgatatttg tttaatcccg cgctccccat 3396781 cattttttcc atcatcagct ggtctgtcga tggcggcgcg gcgggacttg gcgtaacgct 3396841 cggctgtatg cggggcgcgc tcgcgttctc cggctgatca agcacgacat cacacagaga 3396901 acggacaacc gctacataac gcttcagctc ctcatcccgt tcagccgttt ttgctttttt 3396961 tagctcttct tccatctttt gaatcaaagc agatatatga atgttcatga agcaccctcc 3397021 aaaaaaataa atgttgtctt cctgcatttt atcaaattcc tgctgaaaac gcagatatga 3397081 gtttgttatt ttttctgaca aaccttgcgc gattgacaag cagaagagat ttttcacata 3397141 ataaatcacc ataccttaca aaaaggagaa acggaatgaa cagcatcccc tctatcatca 3397201 gcaagcataa agcctatttt gcggcgggac atacgagacc gcttgaatcg agactgaaca 3397261 ttttgcgaaa gctgaaacaa gccgtcagaa ctcatgaagc cgatctcata gccgctctct 3397321 accaggatct ccataaatcc gagcaagaag catactcaac agaaatcgga atcgtcttgg 3397381 aggaaatcag ctttgtcatg aaacggctga gaaaatggtc caagccgaaa cgagtcaaaa 3397441 cgccgttgac tcatctaggc tccaaaagca tcatcatccc tgagccgtat ggaaccgttt 3397501 tggtgattgc gccttggaac tatcccttgc agctggcgct ttctccgttg attggcgcca 3397561 ttgcggcggg gaacacggtc gttctcaagc catcagaata tacgccggct gtttctgcta 3397621 ttctttccaa actcatcagc agcgtttttc caactgatta tgtcgctatg gcagaaggcg 3397681 ggcccgatgt cagcacagca ttattacagc agccctttga ctacattttc tttaccggca 3397741 gtgtagctgt aggaaaaatc gtcatggagg ccgccgccaa acaattaatt cccgtaacct 3397801 tggagctcgg cggcaaaagt ccctgcatcg tccataaaga tgctgacatt cagcttgccg 3397861 ccaaacgcat cgtcttcggg aaatttacaa atgcgggaca aacctgcatc gcaccggatt 3397921 atttatttgt ccacgaggac atcaaaacga agctcacaga agaaatgaag cgtgcgatca 3397981 gagaatttta cggccctcag ccggaacgga atccacagta cggcaaaatc gtcagtgagc 3398041 gccactatca gcggctgctc agctttctga atgatggcat cccgctcaca ggcggacaat 3398101 ctgatcccaa tcatcacaaa attgcgccga ccattctcga acaagtgaga gatgactctc 3398161 cagtgatgca ggaggagatt ttcgggccga ttcttccgct ctttacatac cgcaatatcg 3398221 gggaagtcat tgagaaagtc caatcgcgcc ctaagccgct cgccctgtat ctcttcacca 3398281 caaacaaaga aattgagcgc gctgttttag gaaatctgtc gtttggcggg ggctgtgtca 3398341 atgatacgtt aatgcatgtt gcgacgccgt atttgccatt cggcggcgtc ggggaaagcg 3398401 gcatcggcag ctatcacggg tttgacagtt ttaacacatt cacgcacaaa aaaagcgtcg 3398461 tcaaacaaac gaaccgtttc gacttcgcat ttcgttatcc ttcctccaaa aacgggctgc 3398521 gaatgattcg aaaaatactc aaataaaaaa gcgcagatca cctgcgcttt ttacaaatcc 3398581 ttaatacacc aatcaatcgg cgcctctccc attttctcca aataggcatt cgcccgggaa 3398641 aacggtctgc tcccgaaaaa tccgtttctc gcagaaaacg ggctgggatg cgtcgattca 3398701 atgataaaat gcttggaggt gtcgatccgt tcttttttca tttgagcatg ccgtccccac 3398761 aaaataaaga taaccggccg ctctctttca ctcagcacgt caataattcg gtccgtcagt 3398821 cgctcccagc cttttccctt atgggaattc gcctgtccgc gccttactgt cagcacagta 3398881 ttcagcaaaa gaacgccttg ctttgcccag ctcacaagcg acccgtgatt cgggatgctg 3398941 cacccgatgt cctgctgcag ctcaagaaag atatttttta acgaaggcgg ctgctttaca 3399001 ccgggcttga cagagaagct taaaccttga gcctgtcccg gcccgtgata cggatcttga 3399061 cccaaaatga cgaccttgac atcatcatat gatgtataat gcagcgcgtt gaaaatatcc 3399121 cggctgtccg gataaatcgt ttgctccgcg tattccctct tcagcatctc tctgagctct 3399181 tgataatacg gtttctcaaa ctcttccttt agctgattcc accagctgtc ttgtaaaagc 3399241 tgtttcaaga ttcaggcctc cttacgaacg atgaagtctg gaatagacag gctcgccatc 3399301 ccaaaccatt tcactttttg cttcccgcct cttcatctca ggctcttcaa gcaggacggc 3399361 aaagtttttc gtcggcagct ccccgagtcc gtgcttttca cttaaacgat ccaaatattg 3399421 cttccgcttg gcgccaaggt cagcagactg attgtctccc gcgtcactga aggcataaat 3399481 cacgctggcg caagggacac gcttcacccg gtaatccttg gccgcgcgca aataaaaatc 3399541 ccagtcccag taattgtgca catcagcatc gaaatacccg atttcatcat gcagaaaacg 3399601 tctgtacatg ctgcccgacg gcacgtatgt agaaaacact ctcatatcct catagtcagc 3399661 ggtataagca aacaatttcc gtgacactgg ataccttgtt ccgtttttct cttcaaacga 3399721 aactatttcc gcatcagaat gaacgaagtc tgccgtttct atttcctttg ccattttctc 3399781 gatatgccct ggcgtaaaga aatcatcgtc atcacacagc ataatgcaat ccccagacgc 3399841 ctcttttaca ccggcatttc tcgcagccac atgccccgag ttcttttcta aattgatgac 3399901 agcaatcggc agctccggat aaagtgcttt gaccggcacg accgattccc cggcatcatt 3399961 cacaataata atttcatacg gcatcaaggt ctggcgggaa atcgactcca aaagctcaca 3400021 caaagccgga atccgattat aggtcacaat tacgatagaa atcttcatga tgctctcctt 3400081 ctcattttca tagtcatgta ctattaaaac atatattgga cgggagatca gtgggaatat 3400141 cctactgaaa cggcatacta caatgataga aacagcaaag tggctccgat cagaagcacc 3400201 atgatcagca tcagatctcc aaagacatga aagatatctt tcatgcggac gccattcgga 3400261 aggataagac gccacagctt agattgatag accggcagca gcaccagtgc ataagaaaga 3400321 cacaaaaatg taaaagccgg cggcacaaaa gcacagcctg catcgtccca attcatcatg 3400381 atgtctttca tactagatcc atccaataaa aacaaagata tcatgagggc tagcaacaca 3400441 aaggacccca attgaacctc aaacaggcgc attttctggt tatatgcaaa tcggaccgcc 3400501 caaaaccaga cataagcata tgaacatagc agcgtaagaa tggcacctgc tgtaaagacg 3400561 acatcaggca gccgatcaag cagaaaaaca aaaggcaagc tggctgccat agccaagagc 3400621 atgcagccac cagtaaacaa aaatactgcc ccatgagcta caaaaccata taaacaagag 3400681 ctaatcctca cgacatacac ctcctttaca tagaaattct atgtatatac ctaaaaaatc 3400741 agacaagctg acgcctgcca atataacagc ccattcggcc aaataacgga aataacagcg 3400801 ttgcaaaagc acaagttcca acaaaccaag gtgtcaacaa ggattgaaac agcgcagcag 3400861 gaattacatt gaatagaaaa acaagcataa aaatgacgtt tggcaccatt gagatcagaa 3400921 tcgtatgtag aacaagcttt tctccgcgtt ttccaaactc cttcacgcct tgatacccaa 3400981 tcagcaccca gtagatcata tatgcagcta agatcagcca aacagaaaca gaaatgcctt 3401041 tccatactgc ttgaacaaac ggtgattcaa gccatacatg cattattgta atcgcaatgc 3401101 cgacagcgaa tagggcactg ttacagaaaa gatggaacat caaaaacgca cgaaacgtta 3401161 ctggctgtat tttcttaaac gaagaaacaa tgtcagttgg tgttccaaac gcctgcaata 3401221 aagtctgcat agcttcctcc tcactctttc cttcctgaaa agagcgaaac agatgatgtt 3401281 caatatggct ctcaatctct tctatcatcg cctcaccctc aggaagccct ttaagcccgc 3401341 ttttgatttc ggatacatat gtttctttat ccattttgtc cgctccactt cagtattcgg 3401401 tccatcatgg ctgaaaatac gctccattcc ttcgtgcgtt ccgccagcac ttctttgccc 3401461 tcgtctgtaa tccggtaata tttgcggtcc ggtcctttct cctgcttctc ccagtaggaa 3401521 gaaatatacc cttggcgttc aagcttgtga agagaaggat acaaggtccc ttctttcatc 3401581 tgcagttcat ttccgctgcg gcttcccatt tcttttacaa gctcatagcc gtacatcggc 3401641 cgctcgttca gaagcgtcaa taccaatata accgtgcttc ccttaaccag ctcacgattt 3401701 aacatctcaa aacccctacc tagttttctt atgtagcatt ttacgaaagc ccgttgagat 3401761 tgtcaaatga ttcctataga tcttctatat tgtgatacag agaaaatcta actataatga 3401821 aagacaaaac atgatggagg ttcaagacat gtctatgcat aaagcactca ccattgccgg 3401881 ctcagattcc agcggcggtg ctgggattca agctgattta aaaacatttc aagaaaaaaa 3401941 cgtatacggg atgaccgcct taacggtgat cgttgcgatg gacccaaaca acagctggaa 3402001 ccatcaggta ttcccgatcg atactgatac aatccgcgcc cagcttgcaa caattacgga 3402061 cggcatcggc gtggacgcca tgaaaacagg aatgctgcca accgttgaca ttatcgagct 3402121 tgcggcaaaa acgatcaaag aaaaacaatt aaaaaatgtg gtaattgacc cggttatggt 3402181 ttgcaaaggt gctaatgaag tcctttatcc ggagcacgcc caagccctgc gtgagcaatt 3402241 ggctccgcta gccactgtca ttacgccaaa cttgtttgaa gccagccagc tcagcggcat 3402301 ggatgaacta aaaacagttg acgatatgat cgaagccgcg aaaaaaattc acgcactcgg 3402361 cgctcaatat gtcgtcatta caggcggagg caaactcaaa cacgagaaag ccgttgatgt 3402421 tctctatgac ggagaaacag cggaagtcct tgaaagcgaa atgatcgata cgccttatac 3402481 acatggcgca ggctgtacat tctcagcagc cgtgacagcg gagcttgcca aaggtgcgga 3402541 agtcaaagaa gccatttacg cagcgaaaga attcatcaca gcggccatta aagaatcctt 3402601 cccgctaaac cagtatgttg gtcctacgaa gcattctgca ctgcgcctga atcaacaatc 3402661 ataaaaaaag gggctgcctt acagagaggc agcccttttt aaatcaccga agacttttca 3402721 cagaaaaaac tgccgatccc atcggcagcc tgtttatttg atttttaaat tgtttgcaga 3402781 tttcctcaaa aatgtttcta tcgactgaac aaaaagtgca tattccttca tttgttcata 3402841 tgcccgcgtg agaatttccg ccgtttcact gtgcggcgtt gttccgccaa gcattttttt 3402901 cagctgaagc agcacatcct tatattcttc tcgcttatct tcaacttggt tagcagcctt 3402961 ttccaaacat tccggtgtta tcttctgttc atgtatattc aagaaaacaa ctccttttac 3403021 agaaaaaaat agtaggttat cgttgaagaa tagcacagat ggctcagatt tcacataaga 3403081 aaatagaagg attttctaca taagtgtcca aattccgaca ttcatttcag atttcccggt 3403141 cgcactggct gttacttcat gatttcccgg gaaaggaaaa tatcttgcac tcaagacctc 3403201 ttctccgtta ttgataaaga tttccacaga tgacgcgtcg agaaacatgt gtacggtatg 3403261 caaatccttg atgcggcaat gtctcgcttc tgttcttttt ccgtcaaagc tctttcgttc 3403321 cagcgtaaca atcccctcgt ctttatggaa ggaaaacgta gccgttccgc ggatactgat 3403381 tgaaaagcca gactccgtat gaatgtcttc cagtagaatc tcagttcttt caggtttttc 3403441 cactggaagc gcaccagatg atccatgcat gttgatgtgt atttttttct catttctgcg 3403501 catggctttt agctcaggca gcggctgctg aatcagcttc tgtcctgaaa gcgtcagctg 3403561 tctcggcagc gtcatgcagt gaatccagtg gcagtcaatg gtcggatggg acccttcatc 3403621 ctgatcaggc accgccatcc atgcaaataa aatccgcctt ccctgatcgt cttcaagtgt 3403681 ttgcggcgcg taaaaatcaa aaccttgatc aagctccgta aattcaccat gcttcagttc 3403741 aggcttgtta taatcgaggc ggccgacaaa ataacctgat tgatatacgt tctgataacg 3403801 gaaaccgtca gcctcaagcc cttgaggcga aacaatcagc acatccgatc cttgaaggga 3403861 aaacaaatca gggcattccc acatgtatcc aaaatcgtcc agcccgttga agcccgcgcc 3403921 ggttatcggg ccaagaaatc tccactctgt caggttatca gaagcaaaca acacagcctg 3403981 ccctttcaaa ttctctgttt gcgcaccaat caccatatac catgtgcctt catgctccca 3404041 taccttcgga tcgcgaaaat gcgccgtata tccttccgga aggcgggcga cgacaccctt 3404101 tttctcaaag gacagcccgt cgtcagaaac agcaaggcat tgatacgttt cccgatttcc 3404161 atcctgatcc ctgacatttc ctgtgtaaaa aagatagagc cgatcgtctt tcgtgacagc 3404221 gctgcccgag tagcagccgt ttttatcaaa ccaatcactc ggagccagcg caatctcttc 3404281 ccgcttccaa ttcacaacat cctgtgtcgt ataatgcccc caaaattttg cgccgtgccc 3404341 cgtctgaaac ggctgccact gaaagaatac atgatagctg cccttccaat aaatcacgcc 3404401 attcgggtca ttcagcagcc caaccggcgg catgatatga aaatgctggc ggtgcggatc 3404461 gctgttagcg atgggctctt ttttctccac ttcttcataa gcccggcgac gaagctcctg 3404521 gtcatgtgct gtcatttttt cctctcctca tcctcattaa tcttcatgac aaatgctgca 3404581 atgaacgctg acactgccgc aatcgccatg ccaatcagat agtgaatcaa gttgctgaag 3404641 ccaaacggag ccgcaatggc gatcatcgga attcccgtta acccgtaagc gtttgcagct 3404701 acatgtgtaa agacgacata tgccccaccc aatgcgcctc cgatcatcgc ggcgataaac 3404761 ggttttcggt agcgcagatt gactccgaat atgacgggct cagtaatgcc gagaaaagcg 3404821 gaaaatgctg ccggaagcgc gatttctttt gtctttgcct ttttcgccat aaagaagacg 3404881 gcaagacctg ccccgccctg tgcgacattc gccattgacc agatcggcag caagtagttt 3404941 ttgcctatat ctgcaattag ccctgcctca atcgcatgga agctgtgatg aacgcctgtc 3405001 agcacgatga gtgaatacgt gcccccgaaa atcagacctg cgacaaaacc ggcatggtca 3405061 tatacataag ttaaagcaac cgtaatgccg gagccaagcg ctctgcctag agggccaatc 3405121 gcgataaaag caacaaaccc ggtgacaatc acagtaacaa atggtgtaac aagcaaatcc 3405181 accgcatgtg gaaccacttt tctcgtccat ttctctacct tgctcatcac atacaccgca 3405241 agcaggacag ggataacagt tccctggtag ccgagaagag cgatatcaaa tccgaaaaga 3405301 tgcatgtaat caggtgtcgc ttccgccaat ccccatggat ttaaaagatt cggatgaatc 3405361 atgattcccc cgatgaccgc tcccaagtat ggattgctgc caaactcttt tgaagcgctg 3405421 accccgatta gaatcggcaa gaaaatgaat gctgcacttg aaaacatatc aagcagctgc 3405481 aaaagcgcag aatccttgct catccaatga aacgcattga tcatacccag caatcccatt 3405541 aataggccgc tggctacaat agctgggatg attggaacaa aaatattaga aagcgttttc 3405601 gcaaatctcg cagcgggatt cagcttttct tttgccgcat cctgatgatt gacgtgttct 3405661 tcacgctcga tatcagcttc tttagaaaag gcatcgaata ctttattcac aaggcctgtt 3405721 ccgaaaatga tctggtactg gccagagctg ctgaaagccc ctttaacgcc atcaagctct 3405781 tctacttgtg cttgatctat ctttgattca tctttcatca ctaaacgcag tcttgttgca 3405841 caatgagccg cgctgataat attttctttc cctccgagaa gctcaatgag gcgttttgca 3405901 gtctctttgt aatccatcta tttctccccc ttttatttaa acaaaaaaga cctaaaattc 3405961 gccaacgaat aaaggacaca gcgatccttt ttcatttacg caaattttag gtcttgcctg 3406021 ctttaccagt cacaatcccg cttattcaga ttaagaatac gctttcatca taaatcatga 3406081 tagcgttttc gtcaactatt tttttagtta aatagtttga tataacatgt agacaaaaat 3406141 tcgtaaaaat taattgtgaa atacttcaca atatcgtgct atactatgct caatcatgaa 3406201 agaaagcagg aaaagacaat ggaaactcaa gcattacaaa aggttgaaca gtatgctttg 3406261 aaaaaacaaa acatattcgc ttcaagcaaa atccgttatg tgcttcggtc cattttggcc 3406321 agtatattta ttggttttgg cattacagcc gcaagcaaaa caggcagcta tttctttatg 3406381 gctgattctc cgtttgcctt tccggcagcc gctgtcactt tcggggccgc tattctgatg 3406441 attgcttacg gaggcggaga tttatttacc ggcaacacct tttatttcac ctataccgcg 3406501 ctccggaaaa aaatcagctg gcgcgacacc ctatacttgt ggatgtcaag ctatgccggc 3406561 aatttaatcg gcgccattct gtttgccatc ctgatcagcg cgacgggact ttttgaggag 3406621 ccttctgttc attccttttt gattcatttg gcagagcaca aaatggagcc gccggcttcc 3406681 gaattgtttt tcagaggaat gctgtgcaat tggcttgtgt gcctcgcctt tttcattcca 3406741 atgtctctca aaggggaagg agcaaagctt tttaccatga tgcttttcgt tttctgcttc 3406801 tttatttccg gctttgaaca cagcattgcc aatatgtgca cattcgccat ctcgcttttg 3406861 atcgagcacc ctgatacagt gacactgatg ggagcagtca gaaacttaat ccccgttacg 3406921 ctcggcaatc tgaccgcggg aatagttatg atgggctgga tgtactacac actgaatcct 3406981 gatcaataaa aaaacttcca gagatcactc cctgcaagtc aaagcggtta ttccgagaga 3407041 tcttgaagac gctggacatg cagcgtgata tagccggcct cggattccgg caaatgtaat 3407101 tgatattcat ttttcaaaaa ctccgccagc tccagcgcac attgataggc gaatgaatac 3407161 tttttttgga tgaaataaag catctcctcg tccatacgat ggagcgcttc atttgattcc 3407221 aaccggctga ccgcgtatcg caaatgcgtg acaaggcgtt gataggaaat gctgttttca 3407281 tccacctttc gattaaagta ttgttttatt ttctctatca tttctttgat catggtcgta 3407341 tgcttcagcg ctgaatacat gctctccgca tccatcttcg ccgtatggat gtgaagggca 3407401 atataacccg cttcatcttc aggcagagac acgcccaatg tctcttttac atgtccgatc 3407461 gcccacaggc cgatctcata ttctttttta tagagcgcct ttatctcatg cagcaattta 3407521 ttctgcacaa gcagcccatt ttgaatcctt tcgatcgcaa aggacaaatg gtcggaaagc 3407581 gcgatatgaa tgtgatcgct cagcggcgcc gcgagctctc cttccgcata gctgatgata 3407641 tcctcagcta tttctatatg ctcctccggc agtgtttgca ggatttgttt gaacttttca 3407701 ttctcgtcgc gcacgacaaa gatcttttcc actttattca tagggatgag atcatttttc 3407761 tttttttgaa aagcgattcc cggtcccatc acgatttttt cctgatcatc ctcttttatt 3407821 aaagccgcat tgttgtttaa tactttatag attttcaaga ggttatctct cccgccaatt 3407881 tgcttttgac tgggatttta cctccttttg accgccatgt aaagatgcgg gcccgctctc 3407941 tcctgctttg gcgattcctt gaaggcttgc aaacatcttc ttttataaag cgcggcggct 3408001 ttcgctttct gcttttcttc ctcattcaca gccatccgcc attcataaaa cgaaacgagt 3408061 cctgcggcct gcacagccgc ctttctttgg tatgtacgct gagccgaata gaccgcggca 3408121 gccgcagttt ttctgtccgg cgtcacccag ttcatcaaaa agaccatcca cacccgtaaa 3408181 gatacaagca aacgtttcat agaaaaacat ccctccgctt ctttttggca ggcagccttt 3408241 ttagcagccc gttttctcag ccgcagcccg caagaaaaga cggccgattt cttttctcgc 3408301 aaactagcgg ctctagcaaa actcatgact ctatgataga ccgtggaaag agaattcttt 3408361 gtcacaatat gagtgaaaaa accaactagt ttttagaagt tttgttgaaa gctgaaagaa 3408421 ttgaaatgaa aattggagaa ccgctttgaa aactttatac acaagttatc ccaaagataa 3408481 gaacaactta atcacaagag atatccacat gtccacaaac tctatctata ttttgtatac 3408541 gaacgtatat tcctaactat atatatacac aggtttattc acttatacac agggttctgt 3408601 gtataactcc ttcgttatac acaaacaaaa tccaataaat ggtccaaatg acacaaggat 3408661 ttttttgaat tttcaagaaa tatatactag atctttcaca ttttttctaa atacaaaggg 3408721 ggaaacacat tgaaaaaggg gatcattcgc tttctgcttg taagtttcgt cttatttttt 3408781 gcgttatcca caggcattac gggcgttcag gcagctccgg cttcttcaaa aacgtcggct 3408841 gatctggaaa aagccgaggt attcggtgat atcgatatga cgacaagcaa aaaaacaacc 3408901 gttatagtgg aattaaaaga aaaatccttg gcagaagcga aggaagcggg agaaagccaa 3408961 tcgaaaagca agctgaaaac cgctcgcacc aaagcaaaaa acaaagcaat caaagcagtg 3409021 aaaaacggaa aagtaaaccg ggaatatgag caggtattct caggcttctc tatgaagctt 3409081 ccagctaatg agattccaaa acttctagcg gtaaaagacg ttaaggcagt gtacccgaac 3409141 gtcacatata aaacagacaa tatgaaggat aaagacgtca caatctccga agacgccgta 3409201 tctccgcaaa tggatgacag tgcgccttat atcggagcaa acgatgcatg ggatttaggc 3409261 tacacaggaa aaggcatcaa ggtggcgatt attgacactg gggttgaata caatcaccca 3409321 gatctgaaga aaaactttgg acaatataaa ggatacgatt ttgtggacaa tgattacgat 3409381 ccaaaagaaa caccaaccgg cgatccgagg ggcgaggcaa ctgaccatgg cacacacgta 3409441 gccggaactg tggctgcaaa cggaacgatt aaaggcgtag cgcctgatgc cacacttctt 3409501 gcttatcgtg tgttagggcc tggcggaagc ggcacaacgg aaaacgtcat cgcgggcgtg 3409561 gaacgtgcag tgcaggacgg ggcagatgtg atgaacctgt ctctcggaaa ctctttaaac 3409621 aacccggact gggcgacaag cacagcgctt gactgggcca tgtcagaagg cgttgtcgct 3409681 gttacctcaa acggcaacag cggaccgaac ggctggacag tcggatcgcc gggcacatca 3409741 agagaagcga tttctgtcgg tgcgactcag ctgccgctca atgaatacgc cgtcactttc 3409801 ggctcctact cttcagcaaa agtgatgggc tacaacaaag aggacgacgt caaagcgctc 3409861 aataacaaag aagttgagct tgtcgaagcg ggaatcggcg aagcaaagga ttttgaaggg 3409921 aaagacctga caggcaaagt cgccgttgtc aaacgaggca gcattgcatt tgtggataaa 3409981 gcggataacg ctaaaaaagc cggtgcaatc ggcatggttg tgtataacaa cctctctgga 3410041 gaaattgaag ccaatgtgcc aggcatgtct gtcccaacga ttaagctttc attagaagac 3410101 ggcgaaaaac tcgtcagcgc cctgaaagct ggtgagacaa aaacaacatt caagttgacg 3410161 gtctcaaaag cgctcggtga acaagtcgct gatttctcat cacgcggccc tgttatggat 3410221 acgtggatga ttaagcctga tatttccgcg ccaggggtca atatcgtgag cacgatccca 3410281 acacacgatc ctgaccatcc atacggctac ggatcaaaac aaggaacaag catggcatcg 3410341 cctcatattg ccggagcggt tgccgttatt aaacaagcca aaccaaagtg gagcgttgaa 3410401 cagattaaag ccgccatcat gaataccgct gtcactttaa aggatagcga tggggaagta 3410461 tatccgcata acgctcaagg cgcaggcagc gcaagaatta tgaacgcaat caaagccgat 3410521 tcgctcgtct cacctggaag ctattcatac ggcacgttct tgaaggaaaa cggaaacgaa 3410581 acaaaaaatg aaacgtttac gattgaaaat caatcttcca ttagaaagtc atacacactt 3410641 gaatactcat ttaatggcag cggcatttcc acatccggca caagccgtgt tgtgattccg 3410701 gcacatcaaa ccgggaaagc cactgcaaaa gtaaaggtca atacgaagaa aacaaaagct 3410761 ggcacctatg aaggaacggt tatcgtcaga gaaggcggaa aaacggtcgc taaggtacct 3410821 acattgctga ttgtgaaaga gcccgattat ccgagagtca catctgtctc tgtcagcgaa 3410881 gggtctgtac aaggtaccta tcaaattgaa acctaccttc ctgcgggagc ggaagagctg 3410941 gcgttcctcg tctatgacag caaccttgat ttcgcaggcc aagccggcat ttataaaaac 3411001 caagataaag gttaccagta ctttgactgg gacggcacga ttaatggcgg aaccaaactt 3411061 ccggccggag agtattactt gctcgcatat gccgcgaaca aaggcaagtc aagccaggtt 3411121 ttgaccgaag aacctttcac tgttgaataa gaaaaagccc tgccgattcg gcagggcttt 3411181 ttaaagatca gtcagcaaac gcctcctgca ataagcgata cgatcggagc ttatcttcaa 3411241 aatgatgcgt gatggtcacc accatgattt cctctgtttc atacgcgtta ctcaaagcta 3411301 acagccgctc cttaacctgt tctttcgtac caacaatcat tcgatttcga ttatcagcaa 3411361 ttcgtctctg ttcataagga gaatacgtat ttttccgaac agcttcatac gaaggaactc 3411421 cctctaaagg aataccctgc tctcccgcca aaagtgtaaa atcaagcaca gccccaagct 3411481 cctctgcctt ctcctccgtg tcagcacaaa gaacaaaaac agcaactgcc gctcgaggcg 3411541 tatctcctaa cacagacggt ttgaatcgcc tcttatactg tctgacagta ccctctccgc 3411601 cctctccatt gataaaatgg gcaaacatat agccagcgcc agattcagct gcgagcagcg 3411661 cgctttctcc agatgagccg agcagccaca catccggagc cgttgaaata tgcggcgcag 3411721 cggtcagatt cggaaaacgg tgtttgtcat ccgccaaatc atgcaaatac atggtcagct 3411781 ccttaatttg ctgcggatac tgatcagcat tgcgcttacc accgtcattc agcgcccatg 3411841 atgcaatcgg cattcccccc ggtgctctgc caagccccag gtcaattctt cctggtgtca 3411901 gcccctccag aacacgaaag ttttcagcta ctttataagc actgtaatgc ggcagcatga 3411961 ctcctcctga tccaacacga attcgctttg ttttcgctgc tatatgactg attagcacct 3412021 caggactgga ccctgccagc cgttttgaaa agtgatgctc agaaacccaa aatctcttat 3412081 atccaaggtc ctcagcagct tgggcaagcg caacggtttg ctgtaaggcc gtttctgcat 3412141 tgctgccctc tgatactgga gattgatcta atatacttaa tgaaaccatc cctaccacct 3412201 catcctcatc gtatcactga tcccctattt tttctccaaa gccgctcaca ctgcttatca 3412261 gtgtccccta tcattcgcca tttatttgtg aaagcatgtc cctatttgtc ggaatatgtt 3412321 acacgtgaaa cataaaaacc cctccagacg gagaggtttg ctttagtttt tattaaagcc 3412381 cttttctttc acgtagtcat ttaaatacgt acgcggcttt tgcttcataa agttcagtat 3412441 ttgatcggac cacgtttctt cccgcttccc gtttgttctt tctctatagt aatcagaaat 3412501 ggttttgtca tacgtattca tagtatgacg gaaatcgtct gtgttcacat tatacgtatt 3412561 ttcatgataa acggcctgct ttggcaatct cggttttttg ccggaaaggt tcgcaggatg 3412621 gcctactgcc agtccgaaaa gcgggagcac atggtcaggc gtttgcagca cctctgtcac 3412681 cttgtccaat tcattccgaa tgccgccgat atagcaaatg ccaagcccca tggattcagc 3412741 ggcaatgctc atattttgcg ctgccagcgc cgcatcaatc aagctaacca taaacatttc 3412801 tgtattctcg agcagctcag aaatatgttc acctttttcc tcagccagtt gttgatggcg 3412861 gtacaaatcc gcacaaaata caaaaaagtg tccgttcttc tcaacgtaag gctgattccc 3412921 agcaagcacg gacagctcac gttttttctc aggatcagaa accccgataa tcgaatatgc 3412981 ctgcacatag ctggatgtag acgcagcctg cgcacttttc actaatgtat caatttcttc 3413041 agctgtcaaa agctgatcag taaaagaccg gattgaccga tgattcaaaa tggtttcgat 3413101 tgtgttattc atcacaaaaa cctccttatc actttttatc atatccgaaa aaaagtgatc 3413161 tcaaaagtga aatgctctgc acaaaaaaag acagcctctg taaaggctgt ctgcatatca 3413221 agaattaaaa agataacttc tgtatttcgt cagctgcaca cttgcattat atacaatccc 3413281 aaatccgatt aacgtggaaa gtgtcgagct tcccccatag ctgacaaaca gcagcggaat 3413341 cccggtaaca ggcataatgc caatgttcat tccgatattc tggaatgtgt ggatcacaat 3413401 taacgccgta tagccaacgc aaaagaaaga agcgaaacgg ttaaacggat gtattttgtc 3413461 tatcagaaca acaagcctgt agattaaaaa gaagaacatg atgacaacaa ttgcacagcc 3413521 tataaagcca aatgactcac ctattataga aaagataaag tcagtcgtac tctctggaac 3413581 ataaaccttc aaattagaaa taccattacc taaaatacca ccagatccta ttgccatgat 3413641 ggcctggtca acttgccagc tgtcatttga atcttcctgt gtctcatttg aagcagacac 3413701 ccaagaagtg acccgcttaa tttgataatc ctgtattcca actgatttag caacgtcagg 3413761 aaagtttatc attactaata aaattaatga aatgagtaag atacctgaac cagctatgat 3413821 cgcaatcaat ttccaattta tccctgacat aaaaaccatt acaagaacga taaacataca 3413881 tattcccgca gtcccagcat cctgcatcag gataagacct acaggaataa ctgcgacacc 3413941 cgcaatcttt aataacaagt ggatatcatc cctaagcgtc cgaactcctt taggatttgc 3414001 ttttccaata actgaagcaa gcatcataat caaaccaacc ttcataaact ctgacggctg 3414061 tattgttatt ctaccgatcc taaaccaact ttttgcccct ttaataacag gtgcaataga 3414121 ctcgggactg attttaagaa taatcaaaga taaaatacca atgataaaaa tatataaact 3414181 taacttttca agctgttcta aatcaaagta caaaagaact gtaatggcta cagcccccaa 3414241 aagataaaac acaatttgct gaatccaatc cgtgttccca tactgcccaa actgaccggc 3414301 agcatatatt gatactacgc ttataataaa aaacacacca aatataaaaa tcaaatcccc 3414361 ctggtaaaag gggctttgct gtttcttata tcgactcatt ctatcccgcc ttacattttc 3414421 atcggaaaat cactaatgtt tattatacat gaaccacgtt caagatgaca cgtgaagctc 3414481 gcttcctttt atgttttttc agcatttgcg gcgctttttc agctacacga aatatgacgt 3414541 atcataaacc gaaatgtttc gattgacaca aaacttttca aatgaaaaaa acgccatacc 3414601 aatagaattt gttaaaaaac gaatgcgata atgtgttatg ttcccaaata atgtgatacc 3414661 tcatatagaa atagctaaaa attcagagcc ccatgcccat acattctcct agcacattaa 3414721 acgaaaaaat aagacgatag atccagtcca tttctgcaaa aacacgtatc aatttctgga 3414781 aaacatggta taataattgt aacagaatgt tcaaaaaaca atcacaaaac agacacaact 3414841 cagttcctct atttcatttt tgtaaacgtt atcacaaaat gaaaggagac gggtatgatg 3414901 gacatgtttt ttgcttactt attggttgcc agcgcaacgc ctctctttat ttggcttgat 3414961 aacaaaaaag tcgcactctc agctattccg ccaatcattt taatgtgggt attcttcttc 3415021 ttttacgcaa cagaaagcct ttctccactt ggacacactc tcatgattat cttgtttgcc 3415081 gttaacgtca ttgtcgctca tatcgccgca tttatcattt acggccttcc gtatcttcgc 3415141 agaaagcgaa gcagctgaag acagcaaaaa accctcttcc actgaagagg gttttttgta 3415201 ttattcgtta tggcctgaat gctctgagtg ttcagcgcct ccaggaggat ttccgtccat 3415261 atggtcacca tggtgatagt gagccgcgaa aatccagatg gatccaagta cgataacgat 3415321 cgcgccaaag aatccgaaca gcgtgtttcc gacttggatc gtgccgtttt cgctctctgt 3415381 catatgcatg aacatgagaa gctgcagcgc cgcctgaatg aaggcgaagc cgaagataat 3415441 ccaaagtttt gctgatgagc tcaggtcagt atacactgca acccatagag ccagcagggt 3415501 caaaacgata gacaggataa aacctacaat gtgtttccat ggaaagtgac tgtgttcagc 3415561 agatttgttt gccattttac agacccccca atcccatgag atagacacct gtaaagatga 3415621 aaatccatac aacatctaag aagtgccagt acaagcttga gataaagatt ttagatgaag 3415681 tttgcggagt taagccgcgt ttcttcaact gaatcagaat tcctgtgatc cagaaaatcc 3415741 cgattgttac gtgagttccg tgagttccaa gtaaaacaaa gaatccagac cagaacgcac 3415801 ttgtactgag agccgctcct tcatgtacat agtgaacaaa ctcgttgatc tcgcatccga 3415861 cgaagccggc accgagaaga agagtgataa ttgtccaaat gactacgcct tttaaacttc 3415921 cgcggcgcat ttcatgaaca gcgatcccgc aggtaaagct gctgatcagc agcaagaacg 3415981 tcataatcat taccagattg acttcaaata gttcgtctgg caagacacct ccagctgttc 3416041 tgtttttaag aacgaagaag gttgcaaata gtgttgagaa caacacaatt tctgccccta 3416101 aaaagatcca aaacccgaga atattaagtc tgccggtttc agattgatat tccataggcg 3416161 cgttagaatt gccgtgttct gcatgttcca taactcacgc ctccttattc ggaaatcttt 3416221 ctttccgtct cttttatttc atcaacacta atgtagtagc cgttgtcgta ttcgaatgaa 3416281 cgcagaacca tgcagagcag gactccgatc aatccgacta cgcccatcca gtaccattca 3416341 aagacaagtc caaagcctgc gagaccgaag gcaacagaca taaagaacgg tctgcctgag 3416401 ttgcttggca tatggatttt cttgaatttg ctttcagggt ataattcagt tttttcttct 3416461 ttcatatgca ggaatgcatc ttgagatttg acttcaggaa gcaccgcaaa gttgtaatgc 3416521 ggcggaatcg cagaagaagt cgcccaatca agcgtacgtc ccacacccca tgaatctccg 3416581 ctgatttcac gagtagagta acggaagctg tagtagatgt tatagcaaag gattaagaat 3416641 cctacaccca tcatgaaagc tccgactgtt gagataaagt tcaatgttgt ccagccgtca 3416701 ttcggtccgt atgtgtaaat acggcgcggc atgccttgaa gccccaagaa atattgcggg 3416761 aagaaacaaa tattgaaccc gatcataaag atccagaaga accattttcc gattctttcg 3416821 ttcagcttgt ggccgaacat ttttggatac cagaaaataa atccggcgaa acaagcaaat 3416881 acagtacccg caatcagcac atagtggaag tgagatacaa ggaagtacgt attatggtat 3416941 tgataatccg ctgctgccat cgcaagcata acccctgtaa ccccgccgat aacgaagtta 3417001 ggaatgaacg caagcgccca cagcataggt gttgtaaagc tgattcggcc tttatacatt 3417061 gtaaagagcc agttaaagat tttaaccccg gttgggattg agattgccat tgtcgtaatt 3417121 gagaagaatg agttaacgga cgcactgttc cccattgtga agaagtggtg agtccaaact 3417181 aagaaactca atacagagat ggcgataata gaaccaacca tcgctttgta accaaacaat 3417241 tgttttcttg caaagcttga gatgatttct gagaaaatac caaacgccgg aagaataacg 3417301 atatatactt caggatgtcc ccaaatccag aacaagttag cccaaagcat cggcataccg 3417361 cctgcttcca atgtgaaaaa gtgagcgccg aacaaacgat caaatgataa aagtgctaat 3417421 gctactgtaa gtacagggaa cgcaaacacg ataataacca ttgtgatcag tgttgtccat 3417481 gtgaacatcg gcatacgcat taatgtcatg ccttttgttc tcatttttaa gattgttacc 3417541 ataaagttga tccctgtcat cagggtaccg ataccggcaa tctgaagtcc gaggaggtag 3417601 tagttctcac ccggcccagg gctcatgtcg ttacttgcaa gcggcatata actcgtccag 3417661 cctgcgttcg gagaacctcc gataacgaaa gaaatattga aaagcatcgc ccctacaaag 3417721 aacgtccaga agctcaggtt gttcaagtaa gggaacgcaa cgtcgcgggc accgatttga 3417781 agaggcacaa caacgttgat aagaccgatt aagaacggca tcgccatgaa gatgatcatg 3417841 attgtaccgt gagttgtaaa aatttcatta tagtggtttg agtctaaaaa actgttattc 3417901 ggaagcgcta gctgggcacg catcatcaga ccgtcgacac cgccacggaa taacataatt 3417961 acagcagata taatatacat gattccgagt tttttatggt caacagtagt tatccattca 3418021 gaccacagcc atttccactt tttgaagtaa gtcagaacaa aaataatggc aatggttgaa 3418081 agcgcaatgg aaacttgtgc gcccagaatt aatgggtcac cagttacgaa aaattcgtcc 3418141 catttgaatt tcatgcaggc ttcctccttt cctgatcaat atcattcttc tgtatcatca 3418201 gacttcttaa attcgttttt ctttacgttt tcaaacggat ctgttttaga atgcggtgaa 3418261 acggcttgat agccaaggcg tttgcgcgcc tccatcgcgt actcagcgtc ttgtccgtga 3418321 tcaacgtatt tcaagtgagt agaagagaac gttaattcgt ccacattttc aggaagcatc 3418381 aattcatcat acttctcttt tgtcagctta ggagcctcgt tctgagtctt tttcacccag 3418441 ctgttaaagt ctttttctgt gactgcattc acatcaaact cttggtctgc aaaatgttca 3418501 cctgtgaagt tcgcgttgcg gccttcgtaa gtacccactt tgtcagcctg taagtattga 3418561 tccatcagca ttcctgccat cgcatatttt tgccctccaa gctgaggaat ccatagcgaa 3418621 gccattgaat ctgcagatga gattttgaac aagatcgggc ggtcgacagg aatgtttaag 3418681 tagttgaccg tttcaatatc ctgttcaggg tagctaaata cccatttcca gtctaccgaa 3418741 gtagcataaa caacaagagg ctctttgtct tttgttgctt caggagcttt ttctaacgaa 3418801 tatatcgtct gtactgttgg cacagaaagt gcaatgacga ttaaaattgg gatcactgtc 3418861 cagactactt ctaaaaacgt gttaccgtga atttctgggt tataagatcc attatctttg 3418921 cctttacggt cgcggtattt tactaaaata atggtaaata gaacaaagac gaccccgacg 3418981 ataaacagca taaatccgat agataacagg attaaatcac tttgctgttc agctacaggt 3419041 cctttcggat ctagtactga agcattgctg catcccccaa ggacgaaaac cacagttaac 3419101 agcgctaata caagcaacgg ttttaatgct ctgaacaaga agatcaccat ccttcctatt 3419161 gatgtaataa atctgaagtg catacttcct caaaatcttt tctctacttt gttatgctat 3419221 caaaaacttc acttattagc tttatttttt tataaacttc atcccatttt cgcttaaatg 3419281 tcataaaatc gacaaaaatt gctccaactt tattcacatc tatcgcttaa gatgaaaagt 3419341 ttctagttat ttccgcatat aaagtaaaga aagatgatga agaactaatt ctgacaaatt 3419401 aaggtttacc acaataaaaa acttaggtca atcaaaaatt tcattttgtt aaactttcta 3419461 gataggaatt attttttcct cgtctagcat cttttcacac ggttaccatt ttaacgcatc 3419521 aaatattgaa agaaaaggcg caatgaagag ccaatatgct ctgaattgtc cgtatttttt 3419581 tatgagagca tccagttgtt tatcttatac aaaaaagagg aatgatataa gcaaataaat 3419641 aaaaaatagg atgtgttgca tgatgagttt tcttatttca cttatcgtcg ctattattat 3419701 cggatggctt ggaagcctgt ttgtaaaagg agatatgccc ggaggaatta tcgggtctat 3419761 gatcgcaggt cttataggcg cctggatcgg acacgggctg cttggaacat gggggccgca 3419821 cctagccgga tttgccatta ttccagcggt aatcggcgca gccattgttg tctttctagt 3419881 aagcctgtta accagaaaaa gaggataaaa gcagcagcac ccgaagcgtc agcgctttgg 3419941 gtgtttgttt tgccataaaa atcgaaaaag cctcaaccct agcggttgag gcttttgact 3420001 ggtttggcgc ccaactgatc gatgaacctt ctgaaggcct gttttccctc tgctgtctgc 3420061 ttaaatacac cggcgtgttc aaggatgcgc gcgaatacat gtcccagctc ttcttttatg 3420121 actagatcta cgttctcttt tgttatggtt cttttttcca tcgtccgaag agcccactca 3420181 ctatgctttg cagtgagcgg attttgttct aaggctgttt tcggatcagc agaacatagc 3420241 gccgctgccg tttctttcat ttcctcctgt aagcggccag gcaatatcgc caatcccatg 3420301 acctcaatca ggccgatatt ttctttttta atatggtgga cttcttgatg aggatgaaat 3420361 attcctaatg gatgctcctc atccgtccgg ttgttcctca gtacgatatc gagttcgtac 3420421 aagtctcccc tgcgccgcgc aatcggtgtg accgtattat ggggcgtatc gcctgtatag 3420481 gcggcaatgc cggctttttc atcggaatac gtctgccacg tgcggaagat atggtcagca 3420541 gcttcggcga catgacccgg ttcgtctcct tggagcctga gcacagacat cggccacttc 3420601 actaagccca gcgacacgcc gggataatca tttaattcat aaacgtcttc cgcttctgca 3420661 cgtgccattg gaaaatcatg cgcgccgcct tggaaatgat catggcttag gatgctgccg 3420721 ccgacaatcg gcagatccgc gtttgaaccg ataaaataat gcggatattg gccaagaaat 3420781 gacagcagcc tttcaaatgt ttttttgctg atctccatcg gttcatgttc accttttaag 3420841 acaatgcagt gctccggata atagacatat ggcgagaatt gcaggaacca ttgttcgtcc 3420901 tcaaggatga ccggaatgat tctgtgattt tgccgggctg gatgattcac gcttccctcg 3420961 aagccgacat tttctttaca cagcaaacac atcggataat ttgtctgttc ctgctctttt 3421021 gcagccgcaa tcgctttcgg gtccttttca ggctttgata ggttaatggt catttccagc 3421081 tcgccatatt cggtcggcac cgtccaatga acatttttgg cgattctgtc agtccgtata 3421141 taatagacat cctctgaata ttgatagaat tcctttgtcg cctgttttgg gccgtataat 3421201 gcttttgtct cttcaaattt gcgaatgacc tcggacgggg caggcacaaa acagcccatc 3421261 agctttgcgc tgagcaggtc acggtacgta tctgtatccg cttccattcg gccggtttcg 3421321 gcagcccatt tatagatggg agctagcaag tccggcaggc tttgtgactg cttgatgctg 3421381 gtgctggagt tcggctcggg atgtgtgatg cccagcgctt cataaagacg gtttctcgta 3421441 tattcccgat cccagatcga aatcaatttt cgttccaggc catactcaag cagctgttcc 3421501 agatgttcaa taatactcat atgtcactcc ccctttagtt ctctcgctcc ctctccgata 3421561 tccgcgacat aaaagtccgc tcggagccct gttttttctt gatatctgtc tccaaccttc 3421621 tgaataaaat catcaacgaa ctcatctttt acaatgctga tggtgcagcc gccaaagcct 3421681 gctcccgtca ttcttgatcc aattacacct tcgtgatccc atgccgcaaa cacaagctca 3421741 tcaagttcag ggcatgttac ttcatagtca tccttcaatg aaaggtggga ttccttcatt 3421801 aactgcccga tttcatctat attgttctct ttgaacatat gggccgtctt aatagcacga 3421861 tgattttcgt atacagcgtg ctttgcccgg cgtctgttcg tttcattttg gatcaggctg 3421921 gaatgcgcat cgaaatcaga aggcttgatg tcgcccagtg cggcaatatc gaggcctttt 3421981 ttcagatcaa gcaatgcatc attgcattct tggcgtctcg tattatagct ggagtcagcc 3422041 aatgtccttt ttttgttcgt gttcgcgatg accagcgcga ggcctgagac attgagtttg 3422101 ctatattcat agtcaagcgt gtcacagttc agcagcatcg catgatgttt tttccccatt 3422161 ccaattgcaa attggtccat aattccgcaa ttgacgccga taaaatggtt ttccgcatgc 3422221 tgcgccattt tcacaagctc aagcgcatct acttcaggat gaaaataact ttggagcacg 3422281 acccccatca gcagttcaat agaagcggaa gacgacagtc ccgccccgtt tggaatattc 3422341 cctgaaaata caatgtcaaa gccatgggga actgcatatc ccctctgttg aaattcataa 3422401 atcacgcctt ttgggtagtt cgcccagtcg tcttcttttt gatagcgaat gtcgtcaagg 3422461 ctgcattcct tgatgcctgc gtttctaaag ttatctgaat acatccggac aagcccgtcg 3422521 tttctttctg caacagcagc atatgtaccc attgtcagcg cgcacggaaa gacatgcccg 3422581 ccgttatagt ctgtatgttc tccaatcaga ttcactcttc caggtgcgaa aaaaaaccgt 3422641 aacccctctt tttctccgaa tacacttgca aatatcccct ttagctcttc ccgcatgtgc 3422701 aatcaccttt ctggttttta ttttttattc cccttatttc ttcatagaaa acggcagatc 3422761 atatgctgca gtcctctcat accccttctt cttttgtttt tttaaagacg agccatttgc 3422821 tcgcaacata gttgacgaca acaatgaccg cgttgtcgag tattttggcc aaggtttcat 3422881 ttgtattgaa ctggccgaca agaatgatca tcatgcctaa atctatgccg agagacagga 3422941 cccgaacgct gaaaaaagca gtgagctctt tcagcaggct ctgcagatca tgtgtttttt 3423001 gctgaaacac atataattta tttgttatgt aagcaaacag cacggacaaa atccaagcgg 3423061 caacagtggc ggctttgtaa tccacattca tgatctctac caatatataa aagctggcga 3423121 tattcacaat ggttgtgaaa acccccataa tgatatacat aattatttct ctatacttca 3423181 ctgatgttcc tcgctttctg aaaaactttt caaaattctt ggcctctcgt gctctctgtc 3423241 taaagtaaaa aataccgaga gtgcgtctaa aaagctgcgg aaggtggctg gctggcccaa 3423301 tacatatgat tgtttgatga ttccgtcgag gactgcacat attattttag ccgtatattc 3423361 aggatcaata caggcgtcaa tcagctttct ctccttcagc cacttaatat ataacacatt 3423421 ttcttccacc cacaattcgt acagccggac ataggccttg catttcttta agactttata 3423481 tgtcggcatg ttcatggcaa acgaggtgat gtcccacgac ggcttattta tgtaatagga 3423541 ataaagcagt tctgcagcgt gttttgcagc ctcgtccaat gtcagcgatt tcactgactc 3423601 ccgctccatt tgatcaagat accctataat gatctttttt ttcatctgac gtttttcgag 3423661 aaggtacagc agaaaatcgt ccttgctgac aaaatgaaca taaaatgctc ctttgctgta 3423721 cccggcggct ctgctgatat cttctacaga aaccggatca tacgctcggt caatcaacaa 3423781 attcacgcca gcgtctataa aactttcaaa tgttgcttct cttttaattt gaaatttgtt 3423841 ttttttcata tttttctcct ggcggtaatg attaccctta tcttacaccg gatcaatctt 3423901 tagcggtatt tatttcttta aacggttatg ctattcggtt tcccaggggt catttttaat 3423961 aggctaaatg atttattttc atttacatac tatccagtca gtatttaatt gtttattatt 3424021 ataaataagg tccattggtt atattagtca tttttttagg gaataggtag gtggtttttc 3424081 cttcagtttg tgaacaccga gcaactatgt gtgaaatttg ttgtactcgc ctccatcatc 3424141 gcgctggctt gtcttttatt gcccgcatgt tgcaggaaaa cattttatac aattggaggt 3424201 tactatgaaa actcatgtta aaaaagattt ggacaaaggt tggcatatgt taattcaaga 3424261 agctagatcc attggattag gcattcatga tgtgaggcag tttttagaat ctgagacagc 3424321 atcaagaaag aaaaaccaca aaaaaaccgt ccggcaagac tagtccgaac aggcggatct 3424381 atttacctct ggcttttcta tcacctgatc tgagttttca ccatatcctc tattcaaaag 3424441 caaatcgctg cgctgagctt gaggacaaac ggtgtgtcag ctaactacga cagacagccg 3424501 gtgatgcgat cacctcttgg cacatgcatt gtcataaaga ggtgatgcga acatgataac 3424561 cgtgctctgg taaacagcag ctttgctgag aacaagctgc attcggtgag gttttgaaag 3424621 caaactcgtt tatacacggc cgagcttgaa aaccttcgcc tgtctttaga ccactgtgtt 3424681 cacctcttca cgacttcctt cttttttcat cctccagcta ttgtacaacg cataaatcgg 3424741 actttcagta catacctatt ggtgtacctt tttgcttacg tttagcgaat aaaaggagga 3424801 aagccatgta caaagctgat tataaacaga ttgctgcaac gccgtctttt caagcttttt 3424861 taaagcagaa acgcgctttt attgttcctt ctgcgatttt cttttttgtt ttttattttt 3424921 cactccctgt tttgacatct tatttcacct ttttgaatgc accggccatt ggagctgttt 3424981 catgggcttg gctgttcgcc atcgcccaat tcgctatgac ctggatactg agtactgtgt 3425041 attcccggag agccgcccat ttcgataagt atgtaagcgc tttaaaagag gatctgaagg 3425101 gtgaacagac atgaatatga ctgctttttt attatttttg gcgattgttg gcctgacgct 3425161 tattatcacg tattttgccg cgaagcggac gaaaacgacg agtgagtttt atacggcggg 3425221 cggcgggctc accggcgttc agaatggact ggcaattgcc ggtgactaca tgtctgccgc 3425281 ctcgtttctc gggattgccg gaatgattgc gttatatgga tttgatggct tcttttacag 3425341 catcggtttt ctggtggctt atctcgttgt cttgtacatc gtggcggagc cgcttcggaa 3425401 tcttggaaag tacacgatgg cagacatgat tgccgctcgc tttaaagaaa agaaaatccg 3425461 cggtgtcgcg gctctcaata ccattgccat ctctactttt tatatgatcg cccagctcgt 3425521 gggggcgggc gcgctgatca aactgcttct agggctggat tataccgcgg ctgtcctcat 3425581 cgtcggagtg ctgatgacca tttatgtcgt gtttggcggc atgatcgcga caagctgggt 3425641 tcaaattatt aaagctgttt tgctgatggc cggcacactc gtgatttcga ttatcgtgtt 3425701 ttcgaaattc ggctttagcc ttaataccat gtttgaacag atgaaaacgg ctactccgct 3425761 tggcgctgat tttttgaacc ccggaaataa atacaaggtg ccgcttgaga ccttgtcgtt 3425821 aaacttggca ctcgtgctgg gaaccgccgg gcttccgcat atattgatcc ggttttatac 3425881 cgttaaggat gccaagacgg cccgtacatc cgttgtgtca gcgacatgga ttatcggtgt 3425941 gttttacatt atgacggtat ttctcggctt tggtgccgcg gcatttgtcg gttttgacgc 3426001 gattacggcg gctgatcaag cgggaaatat ggcggctccg cttttagcaa aagcgctcgg 3426061 aggagacttt ctgttcgcgt ttgtatcagc catcgccttt gccaccattt tggctgtcgt 3426121 gacagggttg gtgctgtctg ccgcctcagc atttgcccat gatatttaca gccagatcat 3426181 cagaaaggga gaagcaactg aaaaagaaca aatgaaagcg gccagatggg cttctgtcgc 3426241 cgtgtcagtg ctctcgattc tccttgcgat ttttgcacaa tccttaaatg tggcgttcct 3426301 tgttgcactc gcgtttgcgg tagccgccag cgcaaacctt ccgctgattg tgtttacagt 3426361 cttctggaaa cgattcaatg cctcaggcgc tttatggggc agcctgacag gcctgatcag 3426421 cgcgcttgtg ctggtatcga tgagccctag tgtgtgggac ccggccggag gtgctatttt 3426481 taccggtgat ccgctcattc cgctatctaa tccaggaatt atttccatcc cgctcggctt 3426541 tctcggcgcg tggctcggaa cggtgctgtc gtctgataaa acaattgatg aagatacgtt 3426601 tgcagaaatt caggtgaagg cgcatactgg cgtccatatg gaacaggaat aaaaaaagct 3426661 ctctttatcg agagcttttt ccttactttt tcttctgctc gtcagaaatc gctttttcaa 3426721 atacatcctt gccggcagca cccggaatta cagtgtcacc gataataaag gttggaacgg 3426781 ctgtgatgtc agcctcttca taggcgtgct tcaaggcttg gcgctgcacg tcctgatatg 3426841 ttcttgtttc cagtgctgat ttgaatgatg caccgtctaa tcccacttcc tcggcgagct 3426901 tcgtcaagat gtcaatatcg ccgatatttt ggtcctcctg gaaaaatgcc tgaaagacac 3426961 gggtgttgta ttcatgtcct ttattgtatt ccttcgcaaa atggaagcct tcaaacgcga 3427021 ggtctgtata cggatggggc gagacgtttg gaaaattgat ctcgactcct aatttctccg 3427081 ccattggctg aattgatgtc tgccacatgt actgtttaga aggatcattg accggatcaa 3427141 gctgaggaga tgggcttggg cgcagttcaa acggcatcca ctcgacttca acatcctttc 3427201 cttttatcgc ttcttcaaaa gcggcttttc caacaaaaca aaatgggcag acgtaatctg 3427261 aataaacttt aatgtgtact gtcatgataa tctcctttca tactaaattg attttaaact 3427321 gtaacaatta aagttacaac tgttttttaa taaagaagcc gatttaggct tctttcagat 3427381 tgatgacaaa atcctaaaaa gttttaggat tttgtcatcc tttcagcgtg attgaaaacc 3427441 cttgaagtct aggaaagccg agcattggag cggagcgaat gctctaattc gtgagcacca 3427501 acgcacaggc ttgacaacga atgcgagggt ttgtcgacac gctgaaagaa gcctgtaaag 3427561 gcttctttta tgattccagc aaacgctggg caatatattc tccttttttg cagccgcctg 3427621 ggcatgcgta taaagcagaa ccgattgttt gtgtatattc gtttaacgca tcctttgctg 3427681 aaagagcctt cagcatcggg ataaactgat tgtcgggatt tttttgaaaa ctgataaaca 3427741 ggagacctgc atccatatag ccggttttcg gatcaagtcc ttctgtgtaa gagaaagctc 3427801 ttcgcaaaat ttgtttccca gtagatttcg ctagactgac gtgtgaatta gacggaattt 3427861 gattcagctt cacgggatct gtttcctttt tctgcccaaa aggcgccccc gagctttttc 3427921 tgcggccgaa ggtatcctct tggtccttga gggaagagcg gtcccatacc tcaaggaaca 3427981 ttttgatttt ccgaaaagcc atataggtgc cgcccgtcat ccagtcaggc tcaccagact 3428041 gaatccacac gatcgagttc atcaacgtgt catccttcgt gctctggttg cctgttccat 3428101 ctttaaaccc gaagaggttg cgcggtgttt caccattttt tccaccgctt aaaaagcctt 3428161 tgttcacaaa acggacctca caagtgccga ccgcttgatt tagcaggtta cgcagcgcgt 3428221 gaaacgccac ttgctcgtcg tctgcacaca cttgaatgca gatgtccccg cctccctgct 3428281 tttcatccag gttgtcattg ggcatcgctg gaagagcggc taggtgcttc ggttttttgc 3428341 ttttcagtcc gaagcggtcc tttccgtctt tttcaaaaaa gccaggcccg aatccgaatg 3428401 tgaccgttaa gttggaaggg gataaatcag cagactcacc tgtatcctgc ggcggcagat 3428461 actgatttct ctgctccgct gacattttct tgccagacgt cagcatctgt gtgagacttg 3428521 tccagtttct aaataacgta atgatgtcgc ttttgtcttt tgctgttaca tccagtgcag 3428581 caaaatagac atacgtctga tgggcagttg tgattccggc ctgatgcttt ccgtaaaacg 3428641 gaacaatctg ctcctcctct ttttcatcct ttttcgatgg cttagccgca gtctgaacaa 3428701 gcggagcgag accgccgaga ccgctggcac cgatcgcaac ggctgccccc gccatcgctc 3428761 cccattttaa aatgtcccgt ctgtgaattt gttctggctt tttctgttca tcgctcatga 3428821 tgttacaaaa ctccttttat agcacattcg caatcttcga catggtttca gaaagagtcg 3428881 tcagcttagt gctcagctct ctgatttgct tttcacttaa tttatcataa gacgtatagg 3428941 actgatcatt tgttttgtat tttgccatta aaacttcaaa ttcgctgaac tccgtatcca 3429001 gtttttccgt caagtcggag tgatctttta caagcgcgct tttcactgtt tgataaacgg 3429061 cttcggagcc ttccacattt gccataaggt caactaaatc aattcgtgag tagcgctctt 3429121 cttctcccgt gattttcgaa attccggctt cgttcagaag ctccatcgcg cctgcaacaa 3429181 tttgttcagg tgttaatttc agtgattgaa ttgaaccgtc aagctctttt acatccttga 3429241 gaagctggtc agctgttgcc ttttccccgg aaatatcttg atccttccaa atggccttct 3429301 caagcttatg gaagcctgtc catttgtctc cttcttcaac atcgttttct cgtgcgtcaa 3429361 ttttcggatc aagatctccg aggctttcag cgatcggttc gattcgctcg taataaacac 3429421 gcgctttcgc atataacgtt ttggactttt cgatatcgcc ggatttcaca gcacccgtaa 3429481 atgcttcagt cgctttgaca agctggtcac tctgctcttt gacatagcct ttatactcat 3429541 ccgctgcttt tgccagctga tcgctagcct ttttgccgct cttcttcgct tctgtcaggt 3429601 cttctaagga tgctttcaat gactcggatt ctgtcttgat ttttcctgca tccggtttgt 3429661 ctttttgcgc ttctgtgtag attggctgaa gatgcttttc gatttctgta tattcgaatg 3429721 gatagtcgct gcgaatatcg ttttcaaagg aaagccagta gctgtttaac tctttcccct 3429781 tcttttcaat ctctttttgg tctccttttt ccactgagtc attcagctta gaaatgatgg 3429841 tttccatttt atttacggat gcggtgattt ctttagtgac cccgcttttt tcagatgaag 3429901 ctttttcttt ggttgaagat gtgtcattgg ctccgcagcc tgcgcacagc gcaaggatgc 3429961 atccggctga tacagcgatt tttgtgaaat tcattttgtc agttcctttc cgtttgtaaa 3430021 atgttttgcc gcttctgaaa caagcgcaat cagtaaaaag agtaaaatca acatttgcgg 3430081 aatcgtgctg tacacagacg gataaattcc tagcaccgat acagacggca gccagctttc 3430141 tgcatcagac ggaagaatgc ccgccagttg aaggctgtga acgccggttc cgagaaattt 3430201 cacgcacata tacaggacaa ccgccattga tagaagaaaa aacggcttca atggaatgcg 3430261 cattccgagc ttgatcatca gaacaccgac gatgacgaga acgataagcc ctgcggcagt 3430321 tccgccgatc agttcagtga gcgggagctt cccgacaagc ccgatgaaaa agatgaccgt 3430381 ttcgagacct tctcttacaa ctgccagaaa tgcaatgagc gcaaaggaaa gcaggcttcg 3430441 tttttttagt gcctgtgact tctggatatt gattttttct ctccatttat ccattgaggc 3430501 gtttctgtgc agccacaccc cgacatacaa aagcatgaca gcggacagta cgccggtaac 3430561 gccgccaagc aagaaattgt tttctccgaa tacactggag gagaacagaa ccgtgacacc 3430621 gatgccggct gctaaggaaa cagccatgcc ggcggacgcc ccgccccaga tccatgtcga 3430681 ggaacgcgta acccgcgctt tttttgtcat ggttaatagc gctccgatga caaggagggc 3430741 ctccattcct tcacgaaccg ggatcagcgc cgcatcccac cagctgtagc tgcttgaagc 3430801 gatcggctcg agcaattgaa tcatttcgtc aatttgcttt gatacctttt caggatggct 3430861 gccgatctcc gccttcatca gcgccagatt ttcctccgat gtcgtatagg cttctttcga 3430921 ttgggacacg acatctccct caacagcgag ccaggatgta actaaattgt cgattgcgga 3430981 tgacgcttca tccaattgtt ttttttctat gaactgtttt gtgtctttca agctttgtat 3431041 ataggctgtt aaggacgccc ttgattgacc tgaggatgtc tttttcagca cgacagcctg 3431101 ctgataggtt tctaaatgag acgcaagctc ttcaagctgt gttttgagct tacgtgcgtc 3431161 ttgattgata aaagaaagag aaatcatcgc gatattcgcg tccatttcac tgtgagaaga 3431221 aaggttttct ttcttaatag aaggttcttc ttttttccac ttcgccttga aggtgtcaaa 3431281 cgtttgttgt gccgaatcca tatccccgtc ttttacggat ttgatcattt gcttgtttaa 3431341 ttgaattaat gcggcgatcg gatcatcttc cgcatgtgcc gcagaaccga aaaccatcaa 3431401 caagctgaat agaataagtg ccagcccccg agccatcatg ttcctcctat aattgaaaat 3431461 gattatcatt gtataacata atcatagcca gttcctgtcc tttgtcaatt aaaatttgaa 3431521 ggtctgaaaa ccttgatgga cagcaaaaaa gctgtccttt tacagaacag ccctttgaag 3431581 gaaaatgaac gattatcttc ctgttttata cgtttgaatt tcctcacgaa acttgcgtgc 3431641 agcactctca ggatcctccg cctgactgat ggcgctgatc atactgacgc catcggcccc 3431701 cgcttggata acaggtgcgg cattatctat tgtgattccg ccgatgccga caattggaat 3431761 gctgatgcct tggcggcgca ctgcttcgat aagagataca ccctgtaccg ctctcgtatc 3431821 ttttttcgtt tcagtcggat agatcggccc aagcccgaca taatccgctc cgtcttcttc 3431881 ggcttgcttc acctcagaca tcgtatgggc agaaacgccg agaatcatat cacctatggc 3431941 agctcttacc tctttcgcat ttgcgtcttc ctggccgatg tggataccat cagctttcag 3432001 attcagagcc aattccacat catcattgac aatgaacgga acaccagctt cacggcaagc 3432061 tgcctgcgct ttttcagcaa atttaatccg agcctctcct gtcagcgcat ccccgccttt 3432121 ttcacggaac tggtacaggg tggcaccgcc ttttaacgct ttttgtacaa ctgtaacagg 3432181 atcggctttc gtattgtttg accccataat gaagtataca gataataact ctttcatcat 3432241 ttcccgagaa atacgagtca tgagacagtc accctttcta tagtcgccca ttcttggacg 3432301 tcttgttcag taacagttga aagcttgttc agcaattcaa tctgaaagct tccagggcct 3432361 ttgtcagccg tctgctgtgc ggcaagctga gcggcgaccc catacgaaga aatggccgca 3432421 atagcagcaa acaatggatt ttcttccaca gcgcaaaacg caccgacgac ggaagtcagc 3432481 aggcaaccgg cgcctgtcac ttttgtcagc agcttgtggc cgttatgaag ggtgtataca 3432541 tgtgacgtgt cggctatgac atcaacttca ccagttatcg caatgaccgt gtttagcttt 3432601 tgtgccgcct gctgagccag ccggatgatg tcgcctccac cttcacccgc atcaacacct 3432661 ttgatcagcc aatcggtcac gccgacggta tgggcaattt ccgccgcatt tcctctgatt 3432721 gcagcaaggc gcacctcacg aatgatgtca cgtgccgatt cagtgcggaa cggtgttgct 3432781 ccggcaccga caggatcaag aatgacggga acgccatgtt cattagctga ttttcccgcg 3432841 atgatcatcg cttcgactga ctccttgctc agtgttccga tatttaaaac gagtgcaccc 3432901 gcaattttcg ccatatcggc gacctcttct tttgcgtacg ccataacggg cgatgcgccg 3432961 agcgcgagca ggccgtttgc tgtgaaattc gttacgacat tgttggttat gctatgcacc 3433021 agtgggctat gccggcggac agccgtaaga cattttgctg ctgattgtgc atccatattt 3433081 gcatcatcct ttactatctt ttttcgggtc ccataaatac gatttcgtat gttcgagcca 3433141 agctctggcg gcaaacgaca agtacctgtc ctttctccaa ataatggcga ggtgccaagg 3433201 gatgaccgga tcgacaagcg gaatgacttt cactttttcc gggtcaaggc cgcggcagat 3433261 ccgttccggc aaaagcccga tcccaaggtt ggcggatacc atctcactaa taaaatccca 3433321 ttgtgatgtt tcataaatga tatggggccg gaacccagcc ttgatacatt ccgtcataat 3433381 tcggttgtgc aggacaaaat cctctctgaa gaaaataaaa ggctcgtcct tcaactcacg 3433441 cagctgacat tctttctcat cagccagccg gtgggaaggg tgaacgacaa gcattaaggt 3433501 ttcttttacg attgtaaacg aatgaaagat atcttcgttt gcgggaagga ccacaacgcc 3433561 gatatcaaga gagccgtccc cgacaccttc ttggactttt atagaaccgt cttcgactag 3433621 ctgaaaggtg acattcggat agttttcacg gaaatcgccg agcactctgg ggaaaaaccc 3433681 cgatccgatc atcggcggca gtccaatccg tacgtgccct ttcttgactt ccataatatc 3433741 atttaattct gacgtcaggt tttgaaatga tttaatgatt tcctgcgcct gcacatacat 3433801 gctatgaccg gcatcagtca gttccacctg cctgccgttt cggtaaaaca gttcaattcc 3433861 gagctcttct tctaaatttt tgatcatttt tgatatcgtc ggctgagaaa cataaaggga 3433921 ttgggaagcc ttcgtaaaac tttttaaacg ggcgacttcc aagaaatatg ttaaatggcg 3433981 gatatccatg cgcttcaccc tttctataga caaaaggaat acttcttatt cttaatatat 3434041 attttaccta tagagagacc ttatgtacaa taagtatata agggaggcat caatatgaaa 3434101 aaactgttgc taaccgttat tcaaatcgct ctgttattta tatttgctcg gctgattaat 3434161 tgggtgacag cccttcttca tataaatatt cccggcagta taatagggat tgtgattctt 3434221 ttcacattat tgcactttaa cattatcaag cttgaatgga tcgagcttgg tgcagcgtgg 3434281 cttctcgggg agctgctttt attttttatc ccgtctgccg tcggagtgat tgaatacgga 3434341 gacattatgt cgaaatttgg tgtcagcatt ctgcttgttg tcatcatcag cacgtttgtc 3434401 gtgatggtgt ctacaggaac gcttacacaa ctcatcgcaa agagaaagga gaaaaagcat 3434461 acgtgttcat cggaattgta agtttgtttt taacggtttt ggtgtattta ggagcaaaaa 3434521 aggtatatca acgctttccg cgtgtttata cgtcgccgct attggtgacg cccgctgtat 3434581 tagtcggtct gctgctgctg gtgaatgtcc cgtacgagtc ctataatctc ggcggcggat 3434641 tgctgaccga tatgctacag ccggccaccg tggcattcgc gatcccgtta tataaatatt 3434701 tccctgtttt aaagaaatac gcagtggaaa ttattttgaa tgtggccgtc ggttcatgca 3434761 tcgcgattat ttctaccgct cttattgcga aatggcttca cctcggcacc ggcttaattg 3434821 acagcctcgt cccaagatca gtgacaacgc cgatcgcgat gaacgtatct gaaatgatcg 3434881 gcggtatgcc tgccgtcaca gccgtgtttg tgattttaac cgctttgctc ggcacagtga 3434941 tcggcccgat ggtcatccgt tatttccgca ttgataacga aattgcgcgg ggcgtgctgc 3435001 ttggcacaag cgcgcacgga gcgggaacgt caaaggcatt tgagctcagc tctgtgtccg 3435061 gcacgatttc cagcgtgtcg atgatcttag ctgcgattat gacgctttgc gcggcgccgt 3435121 ttttgctttc atttatgtaa aaaactgtcc tctcgagggc agtttttttt atgtgcttcc 3435181 ccttattgaa aagctggcga attccaatat aatgtatttg tggataccaa aggaggcacc 3435241 ctgatgcaca acttgcaggt gaggcggcat tatgccgcgt taaaaggatt ttatttgttt 3435301 gcttttctcg gtacgggcag cataattccc ttactcagta tgtatttaac gaaggaacag 3435361 catttaagcg gatcacaggt cggcttgatc atgtcactgg gcccgattgt gatgattttc 3435421 tttcagccgt tttggggcat gctgagcgac tatacgcaaa aaacgaaagg cctgctggcg 3435481 gtttgcacat caatcacagg catcattgga ttagcctata ttgcatttga cagtttccct 3435541 ctgtttattt tgattgcggc ctgttttgca gcctttcaaa gcacgattat tccactttcg 3435601 gacagcattt cactaaggta cacacaagaa acaaacggca actacggcgg aatccgcctg 3435661 tttggttctc tcggcttcgg tgtcgcggtg tttgccatgg gacaggtgac gaaccagctg 3435721 taccccattc acgtgatctt tatctttggc tgtgcctttc tgtgcattgc tgccatattg 3435781 gcttcacaag tgcccggcca gcagaaaaca acaaaggtca atatccgcaa aggattccgg 3435841 gagcttatca gcaacaaaac tttcctcatc tttatgatca tcacctttac gacatttgct 3435901 ccaaacttag cgaacaatac gtatttcagt ctttttctgg acaaaagcgg cgcgtcactt 3435961 tccgctatcg gcattttatt tttcatcggt gtcatttcag aaattccatt tatgagattc 3436021 gcccaaacat ttatagataa aatggggctg ctcaacgtca ttatgctgtc aggcggagtc 3436081 tcattattca ggtgggcgct ctatttcacg gcgccttcac tatggatcat ttatgcgacg 3436141 gtctttcttc agggagtggc catcggttta tttatcccgg cggcgcttca atatgtgaaa 3436201 aagattaccc caagacacgt tgaagcgacg gcgctgacca tgtacgccgc cattggcaac 3436261 gggttcggca actggttctg cacatttgca ggcgggtaca tttttgacta cgtgtcgatc 3436321 ttcgcagtct acttgctttt tggcattctg agcatagcag gctttggcct gacattatat 3436381 ttaatgaagg ctgaaaaaaa caaacataca cttcatcagc cggctgttac ttttaaacca 3436441 taatgactat aatgaacaaa agaaaggatg tgcgttatga acgggcaaga gcgaaacagc 3436501 atttcgaaag ggttgcaggt tgatattgta ttgaaagcag atcaaaaaac aggaaaactg 3436561 acgagaggga cagtgaagga tattttgacg aaatcaaact ttcatccgca tggcattaaa 3436621 gtccgtcttg aagatggccg catcggccgc gaccagcaga tcgtttctac ataaaaaaaa 3436681 gctgcccctg aacagggcag ctttttcatt attttttctg cagaaggacc actttcaggt 3436741 agttgccttc cggaaatgcc gaaatcgttt tgaaatcctc cggcagcgta aattcctcaa 3436801 tgatcgtgta gcgttcattt gtttctttaa aggcggcatc aataaagcct ttgaacttct 3436861 tcatgccaaa ggcgctgctg tttgtagagg caacaatgac acccttgtca gcagtgatgg 3436921 cgatcgtttc cttcagcagg tttttataat ccttggccgc gctgaaggtg cgtttttttg 3436981 tgcgcgcaaa ggaaggcgga tctagaataa tcagatcaaa gcgcaaatcc ttttttgcag 3437041 catatgaaaa atagttaaaa acgtccatca ctttaatgtc gtgcgcttcg taatccagct 3437101 tgttcacgct gaattgctcg atcgttttgg caagacttcg atttgccacg tcgacgcttg 3437161 ttgttttctc cgctccgcca agcgccgccg ccacggagaa tgcacccgta taagaaaacg 3437221 tatttaaaac ggttttccct tttgcatagc ggtctctgat cgccttgcgc acatgtctct 3437281 gatccaaaaa gatgcccgtc atggcgcctt cattcagatc caccgcgtat tgaatgccat 3437341 tctcttggat gatgatcggg aactcgcccc ttctcccttt cacgaagtca tcatcttcaa 3437401 cgtattgtcc agccgtgtcg aagcgtttct tctcgtaaat cgctttataa tcaagatcca 3437461 tctcatccaa tgcggaaatc agcatgtctt taaaggtgta aattcccttg ctgtaccatt 3437521 gaatcagcag gtagccgtca taatagtcga tggtgacgcc gccgacaccg tcaccctcac 3437581 cgttgaacag gcggaaagct gttgtatctt gagcctcaaa tagtttggcg cgcgcttggg 3437641 ccgcttttgt taatttgctg agaaaaaatg cttggtcaat ctgttcatgt ttattgcggg 3437701 taagcgtcca gccaacccct ttgttttgca ggccgtaata gccccgcgcg agaaactcgc 3437761 cgccgctctc agacacgata tcaacgaggt ctccttcttt catgtgcccc gcactccctg 3437821 cgagagcttc tttttcaata aggggatagc ctttttttat tttggcagcg tgtgcttttt 3437881 ttagggtgag tagcttcata tatgtcgtcc tctttccgtt tgctttctct tatggtacca 3437941 caaaacgcca agatgtctgc attgacagaa aggaaaggtt tttctacgat agacaaaaag 3438001 agttacgagg aggagcagca tggcaaaacg aattgaccat acaggcatca tggtaagaga 3438061 tattaacgcg tccatcacat tttatgaaga ggtactaggc atgaaattga aggatcgcat 3438121 cactcacacg aacggtgtaa tcgagcttgc ttttcttggc tttgaagacg gcccggaaac 3438181 agaaattgaa ctgattcaag gctacagcag cgagcttccc gctgaaggaa aagtgcacca 3438241 cattgccctg ctgacggatg acatcgcggc tgaatataca aaagcggaaa aaatgaacgc 3438301 aaaatttatc gacgaggaga tcacaacact tccaaacgga taccgttatt tctatatcga 3438361 aggccctgac ggtgagtgga ttgagttctt tcagcggtaa aaataaagaa cgtacatttt 3438421 gtgatgtacg ttctttttta tctataccaa ctgatatacg ttgactcatc gcaaatcata 3438481 gcttcccagc ccatacgctc aaccaattca tggatgtttt tatctttggc taaaaagaca 3438541 ttaatgaatg agtcatatac actcataaac acaaaatcca ttttctcatc agttaaaacg 3438601 agctctgttg cggcttcatc aagaaccgtc cgcaagttgg cttcagttat gtccaaaacg 3438661 ccgcggtttt ccacaatcgg ttctgcgtaa taaaaccgat tggatccgtt cgcacctaat 3438721 acctttacca aactcggaat atgaaaattt gaaatatgat cctcactggg ataatagagg 3438781 tctccattta tgttttcatg taacacctca gccaaatcct ctctcgcgaa ctcgtccctt 3438841 aaagcgccta tcgacgtcat taaagccagc gccagctcag catgtgtttg aaagccgcaa 3438901 gaagacataa ccttcttcca ggaaacagcc ttgcctattc ctcttatttc attatcgttt 3438961 ggataaatat gttcataatc attttttctt tttgcattct cccatccttc aggcatttgg 3439021 ataaaaggag aaaagataag agcagcagat gagtattcaa ctggtacttg ttgtaagatt 3439081 ggtgattcgt catctaacca tatataatct agcatgcgca cctcctttac atattctaac 3439141 attcctttcg tttgaaagag atgatcagcc ctatgacagg ctgatcatct atcacatcac 3439201 atttttatcc ccagattcaa ccgcactctc ttcccgccat ttttgatgat cccatattct 3439261 gaaaaacgga tagtagatag cacaggtgat cagcagattt accagctgca taactgcgcc 3439321 cgacaccttt ccgcctgtcg ccaggtaacc tgatatgagc ggcggcatcg tccatggcac 3439381 cgcgattccg gccggtcttg ccaccagccc ggtgctcatg ccgatataag tcgcggtaat 3439441 cgtgaggagc ggtgcgatga taaatgggac aataaggagg ggattcatga caatcggcat 3439501 gccgaaaatg atcggctcgt tgatattaaa tagcgcaggg ccgattccta atcgtccaag 3439561 ctgcttcatt tgtttgctgc gggagcgcac aagcatcgtc aggacaagcg ccagcgtcgc 3439621 cccgcttccg ccgacattga tccaaatttg aaaaaactga gtcgtaaaaa tactcggcag 3439681 cgcctcgcct gcttggaagg cgagacggtt ggcatccatc gcgccgtacc aaatcggcgc 3439741 catgattccg ccaatgatgg aagccccgtg aatcccgcac gaccaaagca gcatctgcac 3439801 aaattcagcg atcaggcttc cgccgagact gccgccaagg atggaaagcg gtgtgccaag 3439861 caggtctcct acgacattgt gcagactctg aaaaggtgtc atttcaatca gaagacgcgc 3439921 cagccatacg agaagcacaa tgataaagcc gggaatcagc gcgacaaatg atttgcttac 3439981 cgcaggcggc acaccgtctg gcattttgaa gacgatattt ttttgaataa tgtaccgata 3440041 gatttcggtt gaaaacaagg cgatcagcat ggcgacaaat aagcccttgc tgccgagcag 3440101 cgtgatcggg attccgcccc ctaccatgat ggactccgtt gagccatgcg gtgtaaacgg 3440161 cacctcaaac ggtgttgcca gcagaaatgc ggcaattgaa atcgctccgg cagaaagggc 3440221 atcgacacca tagctttctg ccagccgata ggcgatccca aaagcggcaa tcatcgccat 3440281 aatatcaaac gaagcgttaa caggatatcc gagcttatcg gcccactcgt tcccaaacac 3440341 actcgccatg aaatcagcat accccggaat cggcaagctc gttaaaatca agaagacaga 3440401 cccgataata atcagcggca tggtcaggat aattccgtca cgcaaagcgc tgagatgccg 3440461 ctgcccggca attttcccgg cgacaggcat tattttttcc tccatcaccc gagtgaatgt 3440521 gctcatctta aaaaccccct tttctcattg ctttgtgaac aacctccgca atgttttctt 3440581 tatcttattt tgaaaacgct tacaaattca tttggaaaat ttcctcttca tgcggaaaaa 3440641 atctgcattt tgctaaacaa ccctgcccat gaaaaatttt ttccttctta ctattaatct 3440701 ctcttttttt ctccgatata tatatcaaac atcatagaaa aaggagatga atcatgaaaa 3440761 acatgtcttg caaacttgtt gtatcagtca ctctgttttt cagttttctc accataggcc 3440821 ctctcgctca tgcgcaaaac agcagcgaga aagaggttat tgtggtttat aaaaacaagg 3440881 ccggaaagga aaccatcctg gacagtgatg ctgatgttga acagcagtat aagcatcttc 3440941 ccgcggtagc ggtcacagca gaccaggaga cagtaaaaga attaaagcag gatcctgata 3441001 ttttgtatgt agaaaacaac gtatcattta ccgcagcaga cagcacggat ttcaaagtgc 3441061 tgtcagacgg cactgacacc tctgacaact ttgagcaatg gaaccttgag cccattcagg 3441121 tgaaacaggc ttggaaggca ggactgacag gaaaaaatat caaaattgcc gtcattgaca 3441181 gcgggatctc cccccacgat gacctgtcga ttgccggcgg gtattcagct gtcagttata 3441241 cctcttctta caaagatgat aacggccacg gaacacatgt cgcagggatt atcggagcca 3441301 agcataacgg ctacggaatt gacggcatcg caccggaagc acaaatatac gcggttaaag 3441361 cgcttgatca gaacggctcg ggggatcttc aaagtcttct ccaaggaatt gactggtcga 3441421 tcgcaaacag gatggacatc gtcaatatga gccttggcac gacgtcagac agcaaaatcc 3441481 ttcatgacgc cgtgaacaaa gcatatgaac aaggtgttct gcttgttgcc gcaagcggta 3441541 acgacggaaa cggcaagcca gtgaattatc cggcggcata cagcagtgtc gttgcggttt 3441601 cagcaacaaa cgaaaagaat cagcttgcct ccttttcaac aactggagat gaagttgaat 3441661 tttcagcacc ggggacaaac atcacaagca cttacttaaa ccagtattat gcaacgggaa 3441721 gcggaacatc ccaagcgaca ccgcacgccg ctgccatgtt tgccttgtta aaacagcgtg 3441781 atcctgccga gacaaacgtc cagcttcgcg aggaaatgcg gaaaaacatc gttgatcttg 3441841 gtaccgcagg ccgcgatcag caatttggct acggcttaat ccagtataaa gcacaggcaa 3441901 cagattcagc gtacgcggca gcagagcaag cggtgaaaaa agcggaacaa acaaaagcac 3441961 aaatcgatat caacaaagcg cgagaactca tcagccagct gccgaactcc gacgccaaaa 3442021 ctgccctgca caaaagactg gataaagtac agtcatacag aaatgtaaaa gatgcgaaag 3442081 acaaagtcgc aaaggcagaa aaatataaaa cacagcaaac cgttgacaca gcacaaactg 3442141 ccatcaacaa gctgccaaac ggaacagaca aaaagaacct tcaaaaacgc ttagaccaag 3442201 taaaacgata catcgcgtca aagcaagcga aagacaaagt tgcgaaagcg gaaaaaagca 3442261 aaaagaaaac agatgtggac agcgcacaat cagcaattgg caagctgcct gcaagttcag 3442321 aaaaaacgtc cctgcagaaa cgccttaaca aagtgaagag caccaatttg aagacggcac 3442381 agcaatccgt atctgcggct gaaaagaaat caactgatgc aaatgcggca aaagcacaat 3442441 cagccgtcaa tcagcttcaa gcaggcaagg acaaaacggc attgcaaaaa cggttagaca 3442501 aagtgaagaa aaaggtggcg gcggctgaag caaaaaaagt ggaaactgca aaggcaaaag 3442561 tgaagaaagc ggaaaaagac aaaacaaaga aatcaaagac atccgctcag tctgcagtga 3442621 atcaattaaa agcatccaat gaaaaaacaa agctgcaaaa acggctgaac gccgtcaaac 3442681 cgaaaaagta accaaaaacc tttaagattt gcattccaag tcttaaaggt ttttttcatt 3442741 ctaagaacac cacacacaac ctttttccca tccattgtac aggcttttca tactattgct 3442801 atacagccat gaacagcata aaatgaacgt tattacagtt atcaccacat atggcgggat 3442861 tgtgactggg caggcaggca agacccaatg atgcaaaggg agtattaatg cctaaaaaac 3442921 agggcatttt aactcttctt ttcgtgttgg gctcataacg gcgccttgga caacccccta 3442981 ttctcatgct ccgtcgtcga cgcgggcatt tttgtcattt tcagccggta tttctcactt 3443041 ttttcatttt gattgtcaac ttttcatttg atacgatgaa caagccgact tttcttcagc 3443101 aaaggaggtt ttaattgctt gcataaagag attgcaaaag aattactgct gctcgcagga 3443161 ggaaaaaaca atattatcag catcagccat tgtacgaccc gtcttcgttt tgatgtaaag 3443221 gacgagacga aaattgatat acatgccatt gagaacctgc aaggtgtgca gggcaccttt 3443281 ttccgctatg ggcttttcca gattatcttc ggagcaggcg tcgtcaacaa aatatataaa 3443341 gaagtcgttc atgtatggga gaccgcgcct tctgaagagc ctgtccacca gaaaaaagcc 3443401 agccggaagc tgaaccctgc cgcagctttt gcgaaaacac tgtccgatat ttttgtgccg 3443461 attattccgg caataacagc aagcggcctg ctcatggggc tgatcggcat gattaaggtg 3443521 tttcattggt tcgctgccgg cagcccatgg attaaaatgc tcgacctcgt gtccagcaca 3443581 gcctttattt tactgccgat tttagtcggc ttcagtgctg cacggcaatt tggcagcaac 3443641 ccatacctag gggcagtgat tgcagggctt ttgacgcatc ctgatctgct ggacccgtct 3443701 atgctcggca gcaaaacccc gtcttcttta gacatatggg ggcttcatat cccaatgatg 3443761 ggctatcagg gttccatgat accgattctt ctttccgttt ttgtcatgag caaaattgag 3443821 aagctattaa aatcgattgt gccgaagtcg cttgatgtcg tgatcattcc ctttattacg 3443881 gtcatggtga cagggtgcct cgcgctgatt gtgatgaatc ccgccgcgtc catcatcggc 3443941 cagatcatga cacaatcgat cgtctatatt tatgatcacg ccggcattgc tgccggagct 3444001 cttttcggcg gcatctactc caccatcgtc ctatctggat tgcatcatag cttttatgca 3444061 attgaggcaa cgctgcttgc taatccgcat gtcggtgtca actttttagt gccgatatgg 3444121 tcgatggcga atgtggccca aggcggagcg gggcttgcgg tattcctcaa aacgaaacaa 3444181 tcaagcctga agaaaattgc gctccccgct tctctgaccg cgtttttagg cattgttgag 3444241 ccgattgtat tcggggtaaa tctcaaattg atccgtccct ttatcggagc agccatcggc 3444301 ggtgctattg gcggagcata cgtggttgcg gtacaagttg tggcaaattc ctacggactg 3444361 acaggcattc cgatgatttc aatcgtgctg ccgtttggcg ccgctaattt tgttcattat 3444421 atgatcggtt tcttgatcgc agccgtctct gcttttatag ctacattgtt tctcgggttt 3444481 aaagaagaga cagaataact ggatttattc gatttcattc ataaaacggg ggatgaaagg 3444541 acaaaaaagc tatgaaaatt aaaagaatct taaatcataa tgctatcgtc gtaaaggatc 3444601 aaaatgaaga gaagattctc ttgggtgcag gaattgcgtt taacaaaaag aagaatgata 3444661 ttgtcgatcc gtcaaaaata gaaaaaacct ttatcagaaa agatacacct gactataagc 3444721 agttcgaaga gattttagaa acattgcctg aagaccacat tcagatttct gagcaaatta 3444781 tctctcatgc cgaaaaagag ctgaacatca aaatcaacga gcgcattcat gtcgcttttt 3444841 cagaccatct ttcttttgca attgaacgcc tgagcaatgg gatggttatc aaaaatccgc 3444901 tgctgaatga aatcaaagtc ctttatccaa aggagttcca gatcggctta tgggccagag 3444961 cactgattaa agataaactg gggattcaca ttcctgatga tgaaatcggc aatatcgcca 3445021 tgcatatcca cacagcaaga aacaatgccg gcgatatgac acaaacgctt gatattacaa 3445081 caatgatccg tgatattatc gagattatcg aaattcaact gtctattaat atcgttgaag 3445141 ataccatctc ttatgaaagg ctcgtgaccc atctccgctt tgccattcag catatcaaag 3445201 caggcgaatc catttacgag ctggacgcag aaatgattga catcattaaa gagaagttta 3445261 aggatgcctt cctgtgtgcc ctaagcatcg gcacctttgt gaagaaggaa tacggctttg 3445321 agtttcctga aaaagaattg tgctacatcg ccatgcatat tcagcggttc taccaacggt 3445381 cagtcgcacg ctgagacaaa caaaaaacgc ttttgatcat ctcaaaagcg tttttttatc 3445441 tgatttattg gttgatcgcc ggattcccaa tcgtattcca cttcgtatag gacatgtaat 3445501 ggaaatactc atcgcgatac ggatgttttg tattggagtt ccaaggcttt tctccgccgc 3445561 agaagtgcac gattgccggg ttttctcttg tttcattata ttgcttccgc cctaacagag 3445621 tcgatggggt tttcagcttt aacatgatat aggtttgagc gttccagcgc ggatgaagtt 3445681 cataccactg atcatacaag atcgcattca gtgcatcttg gtcatgcagc acaagaaagt 3445741 cttcgtctgg gtgttcattg ataaagttga tgactttttc tgtgatgttt tgctttctcc 3445801 aagactcaaa atcaataatc atgatacctg agttaaaata cttccctgta tcagtgacgt 3445861 tcatttcttt caggcgttca tgctgccccg catcctcaac agcggctacg gtgtatggcg 3445921 caatgtctaa gtcccatagc ttagaaatat cctctaggac aagcgcatca caatcgatgt 3445981 aaatcattcg tttgatgctt tcatccttaa ttaagtcggg aatcgaaatg cggtaatacg 3446041 cggcttttgt aatatggctg ctctcaaccg catgttcata catgttggta tccacttcta 3446101 aaaactcaat cggcactccg aatttcaaag tggtttcttc cagtcttttt ttgttatcag 3446161 gcttaattcc gccatcaatg acgtataatt ttacctctct ctcctgatcc atgttagtca 3446221 ataaagaaac gaacatccca cctaaatgac gagcataatt atcatctgcg catgatacga 3446281 tatgcatgat ttcatctttc ctcaatggta ttcatctccc tttttgttgt acaagttaca 3446341 tacccttttt caaaaaaata aacacgttct ccgacatttt tttaaacaga atgtgtgata 3446401 caacaaaaaa ggtgtcattt tttgaagatg cgataaagcc aataaagaat gaaaaagctt 3446461 gcgattgtga tggcttcagc cgagacgata taccacggcc atggcccgag aacatctaag 3446521 agagaggaac cgcccggttt tttcgtcaaa tacatataat tcgcgccaag ccagcgatca 3446581 atcagaaaaa tacagacgcc gtacacatta acaagcagga ctgtcaccca taacgagcgc 3446641 tggcccattc tgtaggtgcc aatcacagcc atcagcagac aggataaaaa cacagacccg 3446701 tgagaaataa aaaagaggat atatcggata tgcggaaatg aaaacatacc gaggtcagga 3446761 gtggcaagag cctgaatcga actgccgatg ccgacaaaaa acaaaaacac aaacagcttt 3446821 ctgctttttg tcactaacat aatagctgac aaatacaccg acaggtcact aagctggaga 3446881 ggcaatgaag tgcgcaccga ccacctgtcc gtggcgacca tccatatttg atagccgatt 3446941 tgcgaaccaa gcaaaagaaa cacaaacaga gaacgcaaaa accggctggc cctcggctgc 3447001 ttgacctcat cttggaacaa aaacaacaga atggccaaaa gggagataat cgctaacgtc 3447061 actacatgct ctgtcgaaaa cagatgaaac ggatcatgct tatagtcgga ttgaacatat 3447121 ttttgcaaaa ctgcaccccc gttttcgggt ttttgtttat tttggcgttg tttgggcttt 3447181 ttttattcaa ccgatatatg ggcttgaagt tcacaccaga ctctgttaaa attcgtttca 3447241 tagctaatga ttctgataat ttaaggcagg cctaaaaaat ggaacgttca catcaacatc 3447301 agcagcttcg gaaggaagaa cacgatacac tttctaagct caaacaaatg cccgtcgagt 3447361 cactcaacct ggaagccatt tcgatcgcta cgaatctgta tcggtctgca caaaggctcc 3447421 gtgtcaaaat ggagactgag gttctttcta cctataacct ttcttggacc gctttctcca 3447481 ttctttatga tctatgggta tggggagcgc tcgaaacgag aaaaatcgct gagctgtcag 3447541 ggatatctac agctacagca agcaacgtga tcaaaacgct cgaaaaaaag agtttttgcc 3447601 gtaaaagcat cgacacaaga gatcggcgac tcgtgtttgt ctcaatcacc gattccggca 3447661 aacaagcgat cgaagaactc tacccggagt ttcacaaagg ggaaacagag ctcattgcgg 3447721 gaatgacgaa ggacgaacag aaaatattga cagggctgct tagaaaggta gctgacaatc 3447781 ttcatacaac ataagctttg acgggaatcc agtagcggtt tgtctccctg tttcagagag 3447841 ccggcggtag gtgcgagccg gcgcacaggc aaacgtgaat tacctcccca agctttcttt 3447901 gtgaacctta gtagcaaaga acgggaaacc gttattcgaa tgagcggaag acaatgtctt 3447961 caaccagggt ggtaccgcgt gcattgagcc acgtccctta ttgggatggg ctcttttttg 3448021 tgtttgtaaa aaaggaggaa aaatgatgag aacatttgag cagctcacag cgtcacaaca 3448081 aaaagaggta gaaagacagc ttcagctata catgacaggc gcccacgaag tcataccgcc 3448141 ggaggaatta aaggcaaagc tcgtgaaatc aatttccacg ggcacgccgc ttaaaattaa 3448201 gctcggatta gatccgtctg caccggatgt acatttgggc catacggttg tgttaaataa 3448261 gcttcgccaa tttcaagaaa acggccacat tgtccagctg ttaattgggg atttcacagg 3448321 aaaaattggt gatccgaccg gaaaatcggc agccagaaag caactgactg atgaagaagt 3448381 tcagcacaat gccaaaacct actttgagca attcggaaaa gtgcttgatc cagaaaaagt 3448441 cgagcttcac tataactcaa aatggctgaa aacattgaat ctagaagatg tcattgaatt 3448501 agcagggaaa ataacggtag cccgcctgat ggagcgcgac gactttgaag aacgcatcgc 3448561 catgcaaaaa ccaatctcac tgcatgaatt cttttaccca ttgatgcagg gctatgattc 3448621 tgtcgttctc gaaagtgata ttgaattagg cggaacggat cagcatttca atgtcctcat 3448681 gggacggcat ttccaagaac gatacaacaa agaaaaacaa gtcgtcatcc ttatgccgct 3448741 cttggaaggc ttggatggcg tcgagaaaat gtcgaagtcg aaacacaact acattggcat 3448801 taacgaacat ccaaacgaca tgtacggaaa aacgatgtca ctgcccgaca gcctgatgaa 3448861 aaagtacatc cacttggcga cagacttaga gcttgaagag aaaaaacagc tcgtaaaaga 3448921 cttagaaacc ggcgccgttc atccgcgtga tgccaaaatg cttttagcca gaacaatcgt 3448981 ccgaatgtat cacggagaga aagcagcaga agctgccgaa cactcgttta aaacagtctt 3449041 tcaggaaaac agcctgccgg aagatatacc ggccgtaaac tggaaaggcg aaaaaacgat 3449101 agcgatgatt gatctgctcg tcaagctaaa gctcctctct tcgaagagcg aggcgcgccg 3449161 catgattcaa aacggaggtg tacgcatcga cggagagaaa gtaacagatg ttcacgccaa 3449221 agcagagata agagagaata tgatcatcca agtcggcaaa cgcaagtttt taaagctcca 3449281 ataatctgat attccgaaac gcttatgacc cttcattcat aagcgttttt ttgcaggtat 3449341 aaagcactgt cttttcaaaa acgctctcca tcttgcagga aactccttta gcatcccgaa 3449401 atattcccca accatacatt taggggaggt ttatttttga tgaaaaagct tttgactgtc 3449461 atgacgatgg ctgttttaac tgccggcaca ctgctcttgc cggcacagag tgtcacccct 3449521 gccgcgcacg ctgtacaaat atcaaatagc gagcgcgagc ttccattcaa agcaaaacat 3449581 gcgtactcta ccatttctca gctaagtgaa gcaatcggcc ccagaatagc cggaactgca 3449641 gctgaaaaaa agagtgccct attgatcgcc tcatcaatga gaaaattaaa gcttgatgtg 3449701 aaggttcaac gattcaacat tcctgaccgg cttgagggta cactgtcttc agcaggacgc 3449761 gatattcttc tccaagcggc gtcgggctca gctccgactg aggaacaagg gctgacggcc 3449821 ccgctttaca atgcgggatt gggctatcaa aaggacttta ccgctgacgc caagggcaaa 3449881 atcgccttga tttccagagg agacctgact tattacgaga aagccaaaaa tgccgaagcc 3449941 gccggagcga aagctgtcat catttataac aacaaagaaa gcctcgtgcc tatgacgcca 3450001 aacctgtcgg gaaataaagt cggcattccg gtcgtcggca ttaagaaaga agacggcgaa 3450061 gcacttaccc agcaaaaaga agccacctta aaactaaaag cattcacaaa ccaaacctcc 3450121 cagaatatca tcggaatcaa aaaaccaaag aacatcaaac atccagacat tgtgtacgtg 3450181 accgcccatt acgacagtgt tcctttttcg cccggagcaa atgacaacgg ctcaggtacc 3450241 tctgttatgc tggagatggc gcgtgtctta aaaagcgttc catctgataa agaaatccgc 3450301 tttatcgctt tcggcgccga agagctcggc ctgctcggct cctctcacta tgtagatcat 3450361 ctatcggaaa aagagctgaa acgaagcgaa gtgaacttca acttagatat ggtaggcaca 3450421 agctgggaaa aagcgtctga gctgtatgtc aacacattgg atggccaatc taactatgtt 3450481 tgggaatcca gccgtacggc tgctgaaaaa attgggtttg acagcctgtc tctgacacag 3450541 ggaggatcat ctgatcatgt gccattccac gaagccggca ttgattccgc taactttatt 3450601 tggggagacc cggaaacaga agaagttgag ccgtggtatc atacccctga agactcgatc 3450661 gaacatatca gcaaagaacg cctccagcaa gcaggcgatc ttgtgacagc cgctgtctat 3450721 gaggctgtga aaaaagagaa gaaaccgaaa accattaaga aacaaatgaa ggcgaaagca 3450781 tctgacattt ttgaagatat caaataaaaa aagacggcac ttgggtgccg tcttttttaa 3450841 tccacttctt tcttaatccc cagcattttc tcatctaggt aatgggcaat ctccgcggct 3450901 tctttcagct catctgttaa ttgcttagga acgtcattgt tcaatttata ataaatttta 3450961 tgttcaaggc tcgcccagaa atccatcgcg attgtccgga tttgaatttc tgctttgacg 3451021 tattccacac ggttcgttaa attcacaggc atctcaatga ttaaatgcag gcttcgatag 3451081 ccattcggtt tgggtgtctg gatataatcc tttaccttta cgattctcaa atcttcatgc 3451141 tgcttcaaca cattcacgac attataaatg tcagaaataa aggaacagat gatgcgcacg 3451201 ccggcaatgt cgtgaatatg ctccttcatt tccttcgtcg taatctcaca gccctttctc 3451261 attaacttat tcacgatgct ttcaaagctt tttacacggg attttgtatg ttcaatcggg 3451321 ttgtgtccgt gaatgaggtt atattcctgg ctgataattg agaactttgt atcgagcgca 3451381 tctagcgcaa atttataaac taataactca tttttccaat cttccattac tgtttttaaa 3451441 tcgtccatat gtgttacaga taaatccatg ttcgtcatct cctttaacgg aactttatcc 3451501 gctgtccatg tactagacgt ccctgtctgc tgcaaggttc tatgaatttt tttacaaaat 3451561 gcggtcgatt gtaacaaaaa aagaccgcat gaaacgagcg gtctttttta ttatcggaaa 3451621 tagctgatca ataatccgat cgagagcagg aatccgaaaa atgtatttgt ttgggctgtt 3451681 gatttcattg cgacaatcat attcatcggc atttcgttct ggacgaagcc cttcactgcc 3451741 tgaaccggct taggcacgct caaaaagacg acaaacagcc atgggcttgc ggcaccggta 3451801 ataaccaagc cgacaaccca gatataagcg acggcaaacg acgcagctaa cagagtaaca 3451861 gctcccttat gccccatcaa aatcgccaat gttttgcgtc cgcctttttt gtcctcttca 3451921 atatcacgaa tgttgttcga caggttaatc gcgccgacaa gaatcgcaat cgggatggaa 3451981 atcaaaatgc tctgcatatt gatcttatct gtctgaatga aaaacgaaat cagcacaaac 3452041 accgaaccca tgcaaatgcc tgagaataat tcaccgaacg gcgtgtacgc aatcggcagc 3452101 ggcccgcctg tatacaggta gccgatcgcc atgccgacaa ggccgatcag cgcaagccac 3452161 cagctgctgc tggcacaaat atagacaccg agcaaaatgg caatcccgta tgaggcaaga 3452221 gctaattgca aaatcgtttt aggcttcatt ccgtggcgta caatggcccc tccgattccg 3452281 actgattctg ctgtatctaa tccgcgttta aaatcatagt attcattaaa taagttcgtc 3452341 gcgatctgga tccataggca agaaaacagc atagccaaaa acagcagcag atcaaccttc 3452401 acataaaaca tcgccaaaac ggttccgagc agcacaggca caaacgatgc ggttaacgta 3452461 tgaggacggg ttaactgcca aaggatctgc cccatgcttt ctttttgcgg cgctgtctga 3452521 ccctcaccct tatttgtttg gttcatcttc ctcttccttt ctattaaaag gcttactttt 3452581 tttcagccgg cagcttaata aaaaactcct tttgcttcct tatctatcat aatgacttct 3452641 cccttatttc acaagatacc gcaagaaggc gttttctttc ttattatacg cttctcgccc 3452701 tgatttcatt aggtttctgc tttcacttga acgaacaggt acagaaaaat ttttttaagt 3452761 acattacact ttttaaaagt taaaaagatc ttttgactcc aggtatcttt tcctttatta 3452821 tgaatcagct cgaaacattc cattcttgcc cttgcaggta taaagattca ttttcaaaaa 3452881 catacgccga tatattaatt tgagggagat tagggaaaaa atgaaacttt ttgagcatct 3452941 gatcgtcaaa taatcatgtg attgtcgaaa aaacgggaag ggaatttttg atatgctgca 3453001 attaatgaaa cagctgtatg aaaaacccgc tgtcaagtgg acatgtcata caggctttta 3453061 tttgatgata ctgcttgttt tgttttttat gtatggtttt cacaccgcga ataccggttc 3453121 atatatttat aacgatttct aattggagag agaataacta tgaaactttt acatgctatt 3453181 caaacacatg cggaaactta tccgcaaacc gatgccttcc gctctcaagg ccagtcgctc 3453241 acgtatcagg aattatggga gcagtctgac cgcgcggctg ccgcgatcca aaaacgcatt 3453301 tctggggaaa agaaatctcc tatccttgtg tacggccaca tggagccgca catgatcgtt 3453361 tccttcttgg gaagtgtcaa agcgggacat ccttatattc cggttgacct gtctattccg 3453421 tccgaacgga ttgcgaaaat tatcgaaagc tctggagcag aattgctgat ccatgcagca 3453481 ggactctcaa ttgatgcagt cggccagcag attcagacag tttctgcgga agaactgctg 3453541 gaaaacgaag gcggctctgt cagccaagat caatgggtca aagaacacga aacgttttat 3453601 atcatttaca cttccgggag cacaggaaat ccgaaaggcg tgcagatttc cgctgcgaac 3453661 cttcaaagct tcacagactg gatttgtgca gactttccag tcagcggagg aaaaatattt 3453721 ttaaaccaag cgccgttctc atttgatttg tctgtcatgg acctatatcc gtgccttcaa 3453781 tcaggcggga ctttacattg cgtgacaaag gatgctgtga ataagccgaa agtcttattt 3453841 gaagagctga agaagtccgg gctgaatgtg tggacatcaa caccttcctt tgtgcaaatg 3453901 tgcctgatgg atccgggttt ttcacaggat ctgctgcctc atgcggacac atttatgttt 3453961 tgcggagagg ttcttccggt ttctgtggcc aaagcgctgc ttgagcgttt tccgaaagcg 3454021 aagattttta atacgtacgg cccgactgaa gcgacagtgg ctgtcacatc ggttgaaatt 3454081 acgaatgacg tcatcagccg cagcgaatcg cttccagtgg gcttcgccaa accagatatg 3454141 aacattttca ttatggatga agagggacag ccgcttcctg agggagaaaa aggagaaatc 3454201 gtcattgcag ggccgagtgt aagccgaggc taccttggtg agccagagct gacggaaaaa 3454261 gcgtttttct ctcatgaagg ccagtgggca taccgaactg gcgatgccgg ctttattcaa 3454321 gacggtcaga ttttctgcca aggacgtttg gattttcaga ttaaacttca cggctatcga 3454381 atggagctgg aggaaatcga gttccatgtc agacagtcac agtacgttcg ttctgctgtc 3454441 gtgattcctt atcagccaaa cggaacagtt gagtatctga tcgctgctat tgtgcctgag 3454501 gagcatgagt tcgagaagga attccagctg acaagcgcta ttaaaaaaga gcttgccgct 3454561 tctcttccgg catatatgat cccgagaaaa tttatctatc aggatcacat tcaaatgacg 3454621 gctaacggca aaattgaccg aaaacgcatt ggcgaagagg ttcttgtatg acgccttaca 3454681 gctcgttttt attctttata ctgcttggca ttcttcttct gccgacgatc attctcggct 3454741 taaacggaaa aagatttcaa gcatacaaca tgttcatatc tatcattata ttggctttaa 3454801 ttttttcgca cgacttacac ggggtcatcg cgctgtgcct gtttacaata tggcaggtgc 3454861 tcctgatcag cggctatctg gcataccggc agaaagcgaa cagcggcttt gtcttttgcg 3454921 gagctgttat cgcgtctatt ctgcctttat ttctgtcaaa aatatggccg tttctttcac 3454981 acccgcagcc gcatcatccg ccgcataacc tgatcagctt tttagggatt tcatatttaa 3455041 cctttaaagg cgttcagctg attatggaag caagagacgg actgctgaaa gaacagctgc 3455101 cattgcaccg tctgctgtat ttcatcctgt ttttcccgac gatttcctcc ggcccgatcg 3455161 acagataccg ccggttcgtc aaggatgaac agaaggcttg gacgaaagaa gaatacgccg 3455221 acctgctgta tacgggaatc cataaaatct tcatcggttt cctgtataaa tttattatcg 3455281 gctacgcgat caatacgtac ttcatcatga atcttcccgc aatcacgcac aataagattc 3455341 ttgggaacct gctgtacatg tacggctaca gcatgtattt attctttgat ttcgccggct 3455401 acacgatgtt tgccgtcggg gtcagctaca ttatgggcat taaatcacca gaaaacttta 3455461 ataaaccgtt tatcagtaaa aatattaaag atttctggaa tcgctggcat atgtctctgt 3455521 cattttggtt cagagattat gtgtttatga gattcgtatt ttggatgact aagaaaaagt 3455581 ggatcaaaaa ccgtatggcc gtctcaaaca tcgggtattt cctgctgttt atgctgatgg 3455641 gggtttggca cgggctcgcg ccgcaatata tcatttacgg cctctatcac gccgttctga 3455701 tgacgtgtta caactttttc gagaagtgga ataagaaata taaatggctg ccgtccaacc 3455761 gctggacaac cattctcgct attgtgatca cattccattt cgtttgcttc gggttttata 3455821 ttttctcagg aaaaccattt catcaccacc attaaaggag attagaaagc tatggatttt 3455881 aaacaagagg tattagacgt tttagcagag gtttgccagg atgacatcgt aaaggaaaat 3455941 cctgatattg aaatttttga agaaggtttg cttgattctt ttggaacagt agaattgctg 3456001 cttgcgattg aaaaccgttt tgatatttta gtgccgatca ctgaatttga ccgggacgtt 3456061 tggaatacac ctaacaacat tgtaaatcag ctgtctgagt tgaaataatg aaaaagcgtt 3456121 ttttcggtcc aattattttg gcgtttattc tattcgcagg cgccatcgca attccatctt 3456181 catggctgac aggcttcatc accgataagc gtgtgaaaga gtcagcaaca gccttgaatc 3456241 cgagtatgtt tcaagggcta tatttacaag atcagatgct caaagatccg acatatcttc 3456301 cgatttacgg gtcttctgag ctttctcggc tggacgagtt ccacccatct aattattttc 3456361 aggtaaacaa tgagggattc acgccatacc ttgtcggcaa aggcggatcc cagtcattga 3456421 ttcattcttt aaacttcgct gcccacatgg atcagctgaa gggcaaaaaa atcgtattca 3456481 tcgtgtctcc gcaatggttt attaagcgcg ggtctgatga acagcatttc gcgccgaact 3456541 attctgcgct gcaagggctt gatttggcat ttaacgatca gatcgatcct gaaattaaaa 3456601 agaaaatgat gaaacgcatg cttcgcttta aggctgtgca aaacgatgcc attctttctg 3456661 agctgtacaa agcaatggta aacggtcaga cgtggaaagt gaacgcgctg aagccggcgg 3456721 cgaaagtgta ttacagcatg ctggaaaaga aagatctgta ttattcaacg acagaatcat 3456781 ccgggccaaa gcgctatatc tcgcagtcag taaaggataa gtcatggtct gaattgaata 3456841 aactagcgga tcaatcgggc aaacgccact ccggttctaa cgattttcac atcgacaacc 3456901 ctgtctataa aaagctgaag ccgaaagtgc ctaagctgaa agggaaaaac aaaggaagat 3456961 cgtatgcggt gtcaccggaa tatggcgact ttgaaatgat gctcgatatc ctgaaggatg 3457021 cgggcgcaga gcctatgttt gtcaccattc ctgttaacgg gaaatggtac gattacacgg 3457081 gcttcccgaa aaaaggacgc actgactatt acaaaaaggt aaataaacaa atcagagcga 3457141 agggcttcca ggttgctgat ttctcagggc atgaatatga cccgtatttc atgaaagaca 3457201 ccattcacat cggctggaaa ggctgggtgt atgtcgataa agcaattgac gaattttata 3457261 aaaccggaaa agtcacttca tcctgagcat ctcataggac gcggctgcat atttcctgct 3457321 aagatttgta atagtaaagg aatcacagcc aacttaatta agaggtgtta catccaatga 3457381 agatgacaaa taatacggtt ttaatcacag ggggttctgc tggcatcggg cttgaactgg 3457441 ccaagcgcct gctggaactt ggcaatgaag ttatcatttg cggacgcagc gaagcacgtc 3457501 ttgcagaagc gaagcagcag ctcccaaaca tccatacaaa gcaatgtgat gttgcagacc 3457561 gttcgcagcg ggaagcattg tatgaatggg ctttaaagga atatccgaac ttgaatgttc 3457621 tcgtcaacaa cgccggcatt caaaaggaaa ttgactttaa aaaagggaca gaggagcttt 3457681 ttgtggacgg tgatgaaatt gaacttaatt tccaagcgcc tgtccattta tccgcccttt 3457741 tcacacctca tttgatgaag cagcccgagg cggcaatcgt tcaggtcaca tccgggcttg 3457801 cgtttaaccc gttagctgtt tatccggtgt actgcgcaac aaaagcggca cttcactcgt 3457861 tctcgcttac gctcagacac cagctccgcg acacgagcgt ggaagtgatt gaaatggcac 3457921 cgcctatggt ggacacgggc ttaaaccaaa aatcacgcga taaacaaggc ctgacgtacc 3457981 ggggcatttc atctgaagaa tatgttcaat atttcttgga cggcttgaag gaaggcaaac 3458041 aggagattac aaatgaacgt gttgaaggtc ttcgggatgc cactcgcgcc gattatgaca 3458101 ggttattcga gcaaatgaac acgcaggaga attaatttct cctgcttttt tcatatgaat 3458161 ttcttacaaa tttgagcaaa cctattgcga ttatttgttg aaggtataca atagaatata 3458221 attattttca aataagtttg ataatataaa caatttaaca gcagggagat tgaccatgac 3458281 taaacaaaca attcgcgttg aattgacatc aacaaaaaaa ccgaaaccag acccaaatca 3458341 gctttcgttc ggaagagtgt ttacagacca catgtttgta atggactatg ccgcagataa 3458401 aggttggtac gatccaagaa tcattcctta tcaaccctta tcaatggatc cggctgcaat 3458461 ggtctatcac tacggccaaa ccgtgtttga agggttaaag gcttacgtgt cagaggatga 3458521 ccatgttctg cttttcagac cggaaaaaaa tatggaacgc ctgaatcaat caaacgaccg 3458581 cctctgcatc ccgcaaattg atgaagaaca ggttcttgaa ggcttaaagc agcttgtcgc 3458641 aattgataaa gactggattc caaatgcgga gggcacgtcc ctttacatcc gtccgttcat 3458701 catcgcaacc gagcctttcc ttggtgttgc ggcatctcat acgtataagc tcttgatcat 3458761 tctttctccg gtcggctctt attacaaaga aggcattaag ccggtcaaaa tcgctgttga 3458821 aagtgaattt gtccgtgcgg taaaaggcgg aacaggaaat gccaaaaccg caggaaacta 3458881 tgcttcaagc ttaaaagcgc agcaggtagc cgaagagaaa ggattttctc aagtactctg 3458941 gctggacggc attgagaaga aatacatcga agaagtcgga agcatgaaca tcttcttcaa 3459001 aatcaacggt gaaatcgtaa caccgatgct gaacgggagc atcctggaag gcattacgcg 3459061 caattcagtc atcgccttgc ttaagcattg gggccttcaa gtttcagaac gaaaaattgc 3459121 gatcgatgag gtcatccaag cccataaaga cggcatcctg gaagaagcct tcggaacagg 3459181 tacagcagct gttatttccc cagtcggcga gctgatctgg caggatgaaa cactttcgat 3459241 caacaacggt gaaacaggag aaatcgcaaa aaaactatat gacacgatta caggcattca 3459301 aaaaggcgct gtcgcagacg aattcggatg gacgaccgaa gtcgcagcgc tgactgaaag 3459361 caagtaagaa aaaagccggc ccattacagg ccggcttttt ttacgcttca attttgttga 3459421 aaaactgcgg cagatacgct ttgtgcgcct ctagcatttc gtctaaaatc tgtttggcca 3459481 cagtatcgga cgggacaagc gggttaatcg tcatggcaag gagcgcagtt tgatagtcac 3459541 ctgtaactgc cgcttctgcc gcgacacgtt caaaggattt gatttgctgg acaaggccgc 3459601 ggacagacac cggcaagtcg ccgacagcaa ttggcttagg gccggttttc gtcatcacac 3459661 agttcacttc aactgcggaa tcgtctggaa tactcgctat tgcaccatta ttgatcgtgt 3459721 tcaccggctg aatgtcatgt ttatcattat aaatggagct gattaagtta catgctgcat 3459781 cactgtagta agctccgccc cgtttttcca gctgcggcgg tttgatcgca aggtttggat 3459841 ctttataaag ctcgaacagc tctttttcga ccttctgtac gacttcagcg cgggtgccct 3459901 ccgtttgtga tgcttccagt tcgtgctcca gcatctcttt tgttttaaaa tagtaacggt 3459961 gatagccgca agggatgaca ttgagcgctt ttaagaaatc cggttcccat tcggcgcctg 3460021 agatattttt catcgtcatc gcgtttttcg ggtcgcccat cgcctcgatg acttgctcct 3460081 tcacacttac gccgtccaag aaaacatcca gcccgaatac catatggttc agtccggcaa 3460141 attggacttc tacgcggtcc acatctacat caagcgcttt ggctacgccc attttgatgc 3460201 cgattggaac attgcaaaga ccgacgactt tcttcaggtt ggagtagcga agcaaggctt 3460261 ctgttaccat gccggcaggg tttgtgaagt taacaagcca agcgttcggg caaagctctt 3460321 ctatgtcctt tgcgatctca aggatgaccg gaattgtgcg caatccttta aacagacctc 3460381 ccgggccgtt tgtttcctgg cctatcactc cgtattttag cggaatgcgc tcatcctttg 3460441 ctcttgcctg caaaagtccg acgcggaatt gggtcgtgac aaagtctgcg tctttcagcg 3460501 cctttctccg gtcgagcgta agatgaatgt caatcgggac gccagctttt tcaaccatcc 3460561 gtttggcgag tgtgccgaca atattcagct tttcttcgcc ctcggggata tcgacaagcc 3460621 ataattcacg gacaggcagc tcatcatacc gtttaatgaa cccctccact agctcgggcg 3460681 tatagcttga acctccgcca atcgttacaa tcttcaatcc ttttgtcata tgcttgctcc 3460741 cctttgctcg gtgatttttt catataactc aatgatctct gcagccatat ccttcactgt 3460801 cattgcattc attaaatgat cctgtgcatg aaccatcaga agcgtcattt ccgtcttttc 3460861 tccgcccgct tcattttgga tcagctctgt ctgataatga tgggcttttg acaattcttc 3460921 agcagcgtct tgaagctttt tccgcgcttc ttctgcgtca ccgcttttcg cagcggcaat 3460981 ggcctccatt gcggagctcc taccgtttcc tccgtgaagg atgatttgaa aaatgatttg 3461041 ttccatttcc tcattcacgc gattcacttc ctttctctac agagccgctt ctttgtcatc 3461101 tgttgctgca ggcgtttgga ccagctccag atcgttttct tctttcagct tctgcttatc 3461161 ccacattctg aagaatggat agtagacaac aaaggacacg gcaatattaa tggcttgcat 3461221 gaccgcgcct gagacttttc ctcctgtcgc caagtagcct gaaaagatcg gcggcatggt 3461281 ccacggcact gcgatacccg ccggtttggc gacaaggccg gtgctcattc cgatgtacgt 3461341 gagtgtcact gtgacaagcg gcgtgatgat aaacggaagt aagagcattg ggttcatgac 3461401 gatcggcatt ccgaatataa tcggttcgtt aatattgaag atggccgggc cgaccgcaag 3461461 cttcccgagc tgcttcattt gtttgcttcg ggcgcgcagg aacatcgtga caaccagtgc 3461521 caatgtggcg ccgcttccgc caatattgac ccagatatcg aaaaattgct gggtgaaaat 3461581 cttaggaagc tcctcaccgg cttggaatgc gatccggttg gcatccattg cgccgtacca 3461641 aatcggtgcc atgacgccgc caacaatgtt tgcaccgtga aggccgcagg cccataaaag 3461701 cattttgacg gcttcggcga caaggcttcc tccaaggctt cctcccagaa tggaaagcgg 3461761 agtccccaat aaaacgctta caatattatg aaggctttca aacggtgtcg cttcaacaat 3461821 cagccgggct gcccaaatta ggaagatgac ggcaaagccg gggattaacg cgacaaatga 3461881 cttgcttacc gccggcggga caccgtccgg cattttgaag actaaattgc gctggataat 3461941 aaggcggtaa atctctgtgg acaccattgc gataatcatg gcgacaaata agcctttgct 3462001 tcccatgagc gaaagcggaa tcccgccgcc aaccatgatt tctttcgtcg cgccatccgg 3462061 cataaacggc acttgataag gtgttgctaa taaaaatgcc gcaagggaaa tggctccggc 3462121 cgacaaggca tcaacaccgt atttctcggc gagccggtag gcaatgccga acgcggcgac 3462181 aagacccata atttcaaagg tcgcgtcgac tgggtaggcc agtttttcag accaggagct 3462241 gccaaacgtt tttgccataa actcagcgta tcccgggatc gggaggttgc caatgatgag 3462301 gaaaaaggaa ccgatgataa tcaggggcat cgtgaggatg ataccatcac gcagcgcctg 3462361 caaatgacgc tgtcccgcaa ttcttcccgc tataggcatg accttttctt ctaagatctg 3462421 attgacttta ttcacatagc ccgcccctct ctatgacaca tgtccaagct gttcagctga 3462481 tttcagcact tccgccccat tgcacgttcc ataatggacg gtattaatga cgtctaccgg 3462541 aacccccttt gactctccta attttttgag ctgcggaagc atgtaacgga cttgcggacc 3462601 gagaagcaat acatccgctt tatcgatatg attttgtaca gaatcgcctg aaactgccca 3462661 aatggtatag tcttttccct gttcctgcgc acttttttcc atcttgctca ccagtaagct 3462721 agtagacatg cctgctgcac aaacgagtaa tatattcatg taaaagaccc cctagagttt 3462781 gatcaatttt gtaatgtcct gctgttgcta tcatcatatt atgaaatcgc tttcataaac 3462841 actcagggtt tttccgcagg caacggaaaa aaggtatata caggctgtca gctcagcatt 3462901 ttttggtcaa acacatccga aagctcttga tatgaacggc atttgatcag ctggttcatc 3462961 gccgccgggt catccaaaat gctgccaagc agtttataca tgctttgtaa atccgctttg 3463021 ttctcctttt cgacacaaag cagacagaca aattgaactc gctgactctc ccaatcgatc 3463081 ggttttttga gcgtacaaac ggcccaaaac gttgttttcg tctgcggaac aagcgggtgc 3463141 gggatggcaa caagattgcc aaaacacgtt ggcgacatgt cttctctttc aaaaatggaa 3463201 tctatgattt cttcatcggc aaagccgcat tcgaccactt tctgccctaa aaattgaatc 3463261 acttcttctt ttgagcgcag atcctcctga aaaaaaacga gttctttttt taggtagcga 3463321 ttggcttttt ccttttcatc actcagaata gattctattt ttgtaaagtc agttccgcct 3463381 aagatggtgt taaccttcag tactggtaca gggagctctt ttttaatcgg aatggtgctg 3463441 atgacaaaat caattgattc gtaggacatt tgatcaagac tataatactc agccgttcca 3463501 agaatatcga gccgcttgcc gaaatgggaa cgcagttttt cgcgcagaag ctgggcgctt 3463561 ccggctcccg atgcgcatac aatgatacag cgtttcggcg ggctttctgt tttttttcgt 3463621 tcaatcgcgg cgccaaagtg gagagccaaa tatccaattt cgttttcatg aatctcaata 3463681 cccgtttgtt cctttatcac gattccggca atgatcccgg cttcaaaagc gagtggataa 3463741 tgttccttga tcgctgccag catcggattt cgaagattca tgccgtatcg gttgcggctg 3463801 atcgccggct tcatatgcag tgccaagccg attttcagct ctttgtcatg caggatgcca 3463861 agcttcagtt cacgatcaac agctttgatc atggcaagtg tcagctgatc ggtttcctct 3463921 tctattgaaa atgtgtcctc tccgcattgt gattgtgtca ttcgttttgt gccaaggaga 3463981 tgcatggtga tgtaggccgt ctcgtctttc ggaaacgtaa cggaaagctt tgattccagc 3464041 tcttttacga tggcttctgc agcctggtac tccttttgat gcaggatatg atccatatct 3464101 ttcgggaaaa gagaaacata gttttccgtt ctgatccgtt tacaggcgat agcgatatgg 3464161 ataatgaggt tattcagtcc catgttggac agagggatgc ggtcgttttt catttttttc 3464221 aagatggcgg aacggatgat ctcaatttct tcttttggca aaatatcagc cttttcattt 3464281 aaaacatcta tctccgtttc tctttcatca acaatgtact ccgccatgca gtacctcatc 3464341 tgcacctcgt ccccgcgcag cttgaagccg taattcggac gtgtttccat gacgatgcgg 3464401 taaggcagca gacgtttctt tacttccttt aaatccgttt ggagtgtaga ttttgagata 3464461 aatagttctt cagcaagttc atcgagcttg agataatggt ccgccagcag cagacgtttc 3464521 ataagatagg ccattctctc ctccggcaat accggcaggc cctttttttg ctgaaattca 3464581 tcttgcagca gtgttctgaa tacttgctcg tcatcaatgc ggagcttgta gccggagcct 3464641 cttacagatt gtacaaaggc accgtggccg cttagcacac cttgaagttc ctttatatca 3464701 ttgcggactg tccgcgtcgt tacgtttaat tgcgcggcaa aaaacgaact tgtcaccggg 3464761 gcttcagccg ccatcagcaa gcgcagaata tcacgtagtc gcccatgaag catgagaaaa 3464821 acctcctaac tagtagatgc agggattcag tgaataggca gaaaggatga tgaagggatg 3464881 cgaaatgtat ataaattcta taatggagag aatggcaagt caatgaacat ccggaggact 3464941 agagggaaaa ctgacctata aaaaaacagc cgggatcagc cggctgttct agatgcggac 3465001 atattctttt gtttagacgc cttgcggtcc ttcatgattt ttcgaacaat cgggtaaatg 3465061 accggcgccc atttgataac ggttttgatc atctttttca aagctccgat tctcccttct 3465121 tttttctcaa ccattcccct gattgcctct tccttaaaca tgctaacgcg acacgtacct 3465181 gtttcccgtc acccagaaac gccatggata atcgcgtgcc tccccgctgt tgtcaatgcc 3465241 gatgcgcggg ccggttgaaa ttgcttccgg tgtgtacccg ctttcgatgt aaagcggctg 3465301 ttccgtgatc cagcgtccgt agtcattcat cgtgacgcca agcgctttcg tcagctttcc 3465361 tggtccgttt gtccattccc tcggactcct gcccggcctt ctctcctcca ttaacagctg 3465421 gccttcatgc ggctcaatcg ccctgattaa tactgcttgc gggacatcct cttccgccgc 3465481 aacgacattc agcaatgtat gggtgtgcat cacgtatgta tatacccgcc cagcttctgc 3465541 aaacatgatc tcagtccgct tcgtccggcg gttgttaaag ctgtgggccg ctctgtctcc 3465601 agcccccata taggcctctg tttccacaat atagcctgac gctgtgcctt cgtctgtttc 3465661 ttttacaaga aggcagccca gaagcgatgg ggcaagctca agagcggttt tttgataaaa 3465721 cgtgatgggc agcggatttt tttctctcgt cacgaatcga cctctccttt taccgatttt 3465781 tgtacattgt accattcccg aagcagatca aaaaaaacgg ctgttttaaa atctttccat 3465841 tcagggaata ttgttaccgt tcaaaaaagg agggccaacc attgaaagat gatcatcaaa 3465901 acaagcagca ccaatcaaat gcccaaggga gcgaggaagc gttttctcat aagacatccg 3465961 ggaaaaacga gtcagaggat accttaacga ataggcaggg gcatcctgtt actgacaacc 3466021 agaatgtgag aaccgtcggg aatagagggc ctacaacact tgagaactat gattttctcg 3466081 aaaagatcag ccacttcgac cgggaacgca tcccagagcg ggttgttcat gccaggggag 3466141 caggtgcaca tggatatttt gaagcgtacg gaagcttcgg agacgaaccg atttcaacat 3466201 acacaagggc caagctcttt caggaaaaag gcaagaaaac accggcattt gtccgttttt 3466261 caactgtgaa tcatggaaaa cactcgcctg aaacattgag agacccgcgc ggttttgctg 3466321 taaagctata tacagaagac ggaaactggg atttggtcgg aaacaacctg aaaatctttt 3466381 ttatccgcga cccgctgaaa tttccggatc ttgtacacgc atttcagcct gatccagtga 3466441 caaacatcca ggatggtgaa cgtatcttcg atttcatttc tcaatctcct gaagcgacac 3466501 acatgatcac cttcttgttt tcgccttggg gcattccggc caactaccgg caaatgcagg 3466561 gttcaggcgt acatgcctat aaatgggtga atgaggaggg caaggccgtt ctcgtgaaat 3466621 accattttga accgaagcag ggcatccgca acctgacaca gaaggaagca gaagagattc 3466681 aagggaaaaa ctttaaccat gccacacagg atctatatga cgcgattgaa aatggcgatt 3466741 atccagagtg ggaagtatat gctcaaatca tgagcgatga tgagcatcct gaactggact 3466801 ttgatcctct tgatccaaca aaactgtggt ataaagacga tttcccatgg aaaccgatcg 3466861 gcaaattggt tctgaacaaa aatccggaaa actaccatgc ggaagtggag caagcttcat 3466921 ttggaacggg agtgcttgtc gacgggcttg atttttcaga cgacaaattg ctccaggggc 3466981 gtacgtttgc ctactctgat acgcagcgct accgtgtagg cgcaaattac ctgcagcttc 3467041 cgatcaactc gccgaaaaag catgtcgcca ccaaccagga aggcgggcaa atgcaatatc 3467101 gggtcgatag agcagaagga caaaacccgc acgtcaacta cgagccatcc attatgggcg 3467161 ggctgaagga agcgaagcaa gacggaaaag accatacgcc gcatgtcgaa ggtgatgtaa 3467221 agcgtgaagc gattgacaga acaaacaact tcggacaggc tggagaaacg taccggagat 3467281 ttactgaatt tgagcggaac gaattgatta cgaatttggt gaatacgctt tctacgtgcc 3467341 gaaaagaaat tcaggatcaa atgattgaga atttcacaaa agctgatcct gactacggaa 3467401 aacgcgtagc agaagggcta aaaaaggtct ccgaaaacaa cagcaacggg ccgatcggca 3467461 caactgaaac ggaacaggct gcaaagcagg ctgaacagga gagtcatccg tctgatccgt 3467521 attaacaaca gcgaacaggg cttttttaga agccctgttt ttttattttt ctattgaaac 3467581 gctttcaata attgtgttgt acttggaagg aaaggggtgg agagatacga tggaattaca 3467641 gcaggacttg attcctcaga aaaaaacaat cggcgcttta gatcacgccg tttttttatg 3467701 catggtattt tgtttctggt tttcaggcta tatttacgtt cctgtattca gtctgtattt 3467761 ggaggatctg cacttttcat atggcgcaat cggcatcatt ctcggcagct acggggtcac 3467821 gcaaatcctt ctgcgattcc cgctcggcct tttgtcagac atcctgtttt ccttgcgcaa 3467881 gcaattgtta attgccgggt tcggcttttc cgtcctcagc agcctgcttt ttctgatgtt 3467941 tgattctttc ttcttcgtgc tggccgcccg gcttttcgcg ggaatcactg cttctacgtg 3468001 ggtgatggcg accattttat acgcacatta tttcaacaat ggcaatgcat caaaagcaat 3468061 gggcatcatg cagtttttta ccgtcatgcc tcagtttgcc agcattgtgt tctgcgggct 3468121 cgccgcagcc catttaggga ggcaggttcc tttttggatg gcgctggcag cttctgccgc 3468181 aggtctggtg atctgctgct ttattcagga tccgtctgct cctcccgcaa accgtggcac 3468241 cattcgtgtc aatcagtaca tcaaagatac attgcggctg ccaaagctga agcttttcac 3468301 catcctgtct atgacggccc atgccgtatt atttatcaca gtgtttggtt ttacgccgct 3468361 ttacatgaat cagctcggaa tgggcgacgc ggagctgctt tgggtgatga gcgccttttt 3468421 cctcccacac gcagccgcca cattaagctt tgtgtttctg cgctttacaa gccgtatcgc 3468481 ttactccgtg atgctcatta gtttcgctgt caccggggtc tgtttgctat atgttccttt 3468541 tttagctgca ttgttcacgg tttgcatcac acacgcctgt attgggctgg cgctcggctt 3468601 cgtttttcct ctgctgctaa gccatgtcgt cgaaatcagt tctgcccgtt taaaaatgtc 3468661 agtgatgggg ttttaccaat cattttatgc gctaggcatc ttcctcgggc cccttcttgc 3468721 cggaaaaatc gcacagctta tcgggcttgc gggagttttt tatggagccg gttctctggc 3468781 atttgccgcc ttttttgtga tgctcgcgca aaaacgtaac atgatcaatt aatagctttc 3468841 ataccgccgg aagcgccaca cagaaaacac ggccagaagc atgatgcaca gaatggagaa 3468901 agtgagtgac catccgaaaa aatctgcccg ctctccatga agaaggatat gctccgcctg 3468961 cttgcaaatc tcagccggaa gccacttcgc accatctgga aatagtgaaa cagcaaagga 3469021 aacggctgct gtgagcccga tcccgcaagc cgcagctgct ccgacagacc ggaatatcgt 3469081 acttccggca aggccggcgg tcacaataaa tatcacccaa agagcgtaaa ggccaaggct 3469141 tgcggcaaag cggctgaatg atgcgtcctc aaacagcagc cggacgtaat agtaagcaag 3469201 cccgtatcca gctgcaaacg acataatgcc gatcacgctt tggatgagcc atttactcac 3469261 gatataatgg gctgccgtca caggccgcga cataatcagc gctgttaccc cttgatttct 3469321 ttcattggct acactgccca tcacgctaaa gatgaccaga gccatgccaa gcgtgttgaa 3469381 ttgagaaagc gtgctgacca tcacttcaga cccggagggc atcgtaaaac tgattttcat 3469441 gccgtcagga aggttccctc catgtgcgat gatttccggc atataataaa tggtcagcgg 3469501 ctgtgtcagc ccgacgatca tcatcgcaat cggcagccaa atcagcttgc cgcttttcca 3469561 tccttccagc cactccttct gcaatagcgc catcatcacc ttcatgcgtg caccaccttt 3469621 agatagacgt cttctagaga ctccgttttc tgttcaaagc gggtgacggt caatcccttt 3469681 cggatacagt cacttaataa tgaccggcca gcgtgtatat caggcagctc gaaaaccgct 3469741 tgggacggat tcttatagac aatagctgag acgtaaggct tctcttcaag ccaaccttcc 3469801 agcttctctt tcactgaaag ggtaaaaacg ttcgtttgct gctgttgttt cagctcctgt 3469861 aactcgcctt tccatgaaat ctcaccgttt ttcataatca ccacttgatc acacacctgt 3469921 tctgcatcgt gcaaaacatg tgtagaaaac agaacggcca tatgcttttt cagctcccgc 3469981 atcatgtcca gcacctcgaa ccgtcctgtc ggatcaagcg cagacaccgg ttcatccaat 3470041 atcaaaaact tcggtttatg gagcagtgcc tgtgccagac cgagtctttg tttcatgcct 3470101 cctgaatagc ccccgatcct tttgtgcgcc gcttcgtgca aaccgacaaa ttccagcatc 3470161 tcgccgattt tctcttggca ttttctcttc gaaaggccgg acagtctccc cgcaaatgtc 3470221 aaaaattcat ttgcggtcat ccacgaataa aaagcaggat actgcgggag gtacccaatc 3470281 aaacgccgat ccagcttttt ctctcctaac agctttatgg ttccagaggt tggcgaaagc 3470341 agtccggcca gcatttgcag agtcgtggtt ttgccggctc cattaggtcc taatagtgcg 3470401 acacactcat tttcattcac gtgaaaactg acattcttta cagcttcatg gtgcctgtac 3470461 gatttgcata atgattcaat agacagcata tcggcttacc tttgctttct gccgacggtg 3470521 aaaaataaaa tcggcccgat aatattgata catacgatga ttgcagccca catccacttt 3470581 ggcccgttcg tccgctcttc ttttatacag ctgataaggg caaacaccgc caaagccagc 3470641 tgtaatacaa tcagcggcaa aatcatttcc caagaaatat tcattgcttg atcccccttt 3470701 tcttccgatc cggcctaatg acaaaaaagt aataacaaat cagaggcatc ggtgcttgaa 3470761 tcaatccgac aatcccccaa acccatgcca tgtgattacg ttttttcgca tcaataaata 3470821 aaaagattcc ctgcgccaat acgatgagac aagccgcaac cgttatgata atttctgttt 3470881 gtgtcatccg cgtttcacct cgcattcgcc gagatgcctt tttttctcag ccgcaatcaa 3470941 aatcggcagc accgcaagca cacaaacctg aagcacaata aacacagcag gagcttgagt 3471001 gaaagctaag attgcagcac tcacaaccat cagcgcgcag aatacaaata aaatgatctc 3471061 ttgaagaagt ttttttctgt attcagcttt catttgtgac agctggtgaa gcagttcttt 3471121 ttgattcggt atagagggat tggctgtttg atcaattttt ttccattctg actttaaatg 3471181 atcagaaagc ttttctttat tcatcatccc actcctttct gatttgctgg agccctttat 3471241 gaactctgga ctttacagtg ccttctttga tttgaagcat caccccgatt tcagcgtagg 3471301 tatagccgta gtaatgcctt aataaaaccg gtgtgcgcag tttagggtcc agctttgaaa 3471361 acagatcgag cgtttcgctc cactctgccc ctttcgccga cacgtcccac ttgatcttgc 3471421 ggattgtttc ctccgtaact gtctgattcc gtttccattc tctctttctc tttttctggt 3471481 gatcgagata gagccgcgat gcaatggaga tcagccatgt ggagaatttt gaacggccct 3471541 gaaagcttct taaatggatg taccctttca gaaaggtttc ctgaacaagt tcctcgctga 3471601 gatcggggtg aagggaaagc tttaacaagt atttatataa gaaagaatag tgatagtgga 3471661 aaagggctgt aaacgcctcg tcgtttccct ctttcgcctg ctggatcagc cgctgttctt 3471721 cttgtgtatc caatgaccgt gatcccccct tttttgtttt tctgccttat gagacgacac 3471781 cggattcaaa agcgttcatc ttttttacaa ttcttttcag ccattgacag atcaggcttc 3471841 ccggccgttt ggctgcatat ccttatttgt aaaccccctt atagtctgtt aagctatgac 3471901 tttatgtcga tttcaaaaaa acatccaata tggaggacga tgcattgaaa gtagaaaggc 3471961 gaacgattga atatattccg aatgaagaaa gacatggtaa agcgaaagat ttatttcccg 3472021 tatggttcgg ggctaatatg catatcacca cgttagtgac cggcacgatt cccgttgcaa 3472081 tgggacttaa tctgttttgg agtgttgccg ctattatttg cggaacctta atcggtgcca 3472141 tatttatggc ttctcattcc gcgcaaggcc ctcagctagg catcccgcaa atgattcaaa 3472201 gccgtgccca attcggcgta atcggagcga ttcttcccct cttcttagtc atgtttatct 3472261 accttggttt cttcgcaagc agcacgattc tggcggccgg aaccttaagc agctttgttc 3472321 ccatcccggg atcatggagc attataggct taagtgccgt atgtttttta ctcaccattt 3472381 tcggccatga tttgattcac aaaatgcaaa aaatcctttc ttggacctct tttgctgtat 3472441 tttttgctgc aacgattctc atttttcaat tgccgattcc ggcaggcagc tggatacccg 3472501 gagcgattga tctgccaatt ttcctagtgg cagtcagcgc agttgcgacg tggcagcttg 3472561 cctacgcgcc gtatgttgcc gattattcaa gatatctgcc agttaaaaca ccggcttcaa 3472621 aaacattttg gtacagctat gcaggtacat ctgtcagctc catctggatg atgctgctcg 3472681 gcgcattgct gacaacctca cttcctgact ttacggcaaa ctcaggcagc cagattgtcc 3472741 aattgttcgg tcccttctcg tttattatgc tgatcattgt gctatttggg caaatggcaa 3472801 tcaatgtttt taacctgtat ggggctttca tgtccacgac aacaacgctg gagccgtttc 3472861 tgaaattaaa agtcacgccc aaagtcagaa tcatcatgat cctgggtgtc acgcttgtcg 3472921 gcacagtctt aagcctactg ggacagagca attttatgga actgtttttg aattttatct 3472981 ttttcatcag ttatttctta attccgtgga cggcaatcaa tttagtcgat tactacttcg 3473041 tccgccacgg aaagtatcaa gtcaaagcca tgttcgacgt aaacgggcct tatggaaagg 3473101 tcaattggat caccacaatt gcgttcgttc tgtctatctt gctggaaatt ccgtttatca 3473161 acacaagctt ttacatcgga ccgcttgcca aaatgtttgg cggcggagac atcgcatgga 3473221 ttatcggctt ggccgtgcct tctgtgcttt actatgtatt aatgaaaccg cgtctgaaaa 3473281 aacgggcggg gtatcaagaa aagctgtctt ctctctgaag acagcttttt tatcattcaa 3473341 atcgtttcca cacgcggggc aggatgtcag atagctcatg agcgagcaac gtatgagcgg 3473401 agtgctcgtc cgtccagagc tcggcgcacg caccatgcaa atagaccgcg tttaatacgg 3473461 cgtgctttgg atcttcatgg cagcagagca tccccaatat catgcccgtc agcgtgtcac 3473521 cggttccgcc cttggcgagc gccccgtttc cggttggatt gagccagcag tctccatcag 3473581 gaaacgcgat gacggtttgg tttcctttta acacaatgac agtctgcagc tgagccgccc 3473641 attcctttgc atattccgct ctttttttct gcaattcgtt cacgggcacc cctgtcattc 3473701 ggaaaaactc gcccgggtgc ggcgtgagga tgacggggcc ctcccgtttc ggatatgtgc 3473761 gcttcgccag cgctccggca tccaaaataa caggacaatc agccgtaagc acatgatcga 3473821 ctgcctgctg tacgctttcc gtttgcggaa ggcccggtcc gatggcaatg gcccggtacg 3473881 tctcttcaag ctgagcatcc gccgcctttt tccagccgtc acgccaatag gtcgcctcgg 3473941 gcaaaacagg aacaattagc gggattacgt tttctgatgt accgatgaca agcttgccga 3474001 gaccgctccg catggcccca agccctgcaa gcagcgctgc tcccggcatg tcgtcacttc 3474061 cagccagcag caaagccgta ccgtacgtgc ctttatggct ctccgcatct ctttcaggaa 3474121 gcgtggccct tacatgctct tccgtccaaa atggaacatt catctctatc cctcctctgc 3474181 tttcttttcc tatttttcct gtcccttttc tttttcaaac aaaaaagaca gccttttagg 3474241 gctgtctttt attttacagg aacatcaagg tgatacaggc ggcgatatcg ttcgtttgcc 3474301 gccagcagct cctcatgggt tccttccatt tctgttttgc cgttttcgag aaatacgatt 3474361 ttatcggctg cttccactcc cgcgagatgg tgtgtaatcc ataaaatcgt ttttcctttc 3474421 agcacctcaa acaccgtttc catcaattca cgttcggtaa taggatcgag gccgactgtt 3474481 ggctcatcga ggatgatgat cggtgtatcc tgcagcaaaa tcctcgcaag tgcgatccgc 3474541 tggcgctctc caccggaaaa acggatgccg gtttcttgta cagaggtatg atatccgtca 3474601 ggcaatgact caatgtagtc atgcagcttg acctgctttg cggcgcggcg cacatcctcg 3474661 tcgcttgctt ctccgtttcc gagcctgatg ttgttcaaaa tgcttgtatc aaacaggtgc 3474721 ggtttttgat ttaacacggc caccgcatcc gcaatctgat cctttaacag cgctgtctcc 3474781 actccgttta acgtcacaga accggagtcc ggtttcaagg cgccttcgat taatgcaagc 3474841 gatgttgatt tcccagagcc gcttcggccg agcagcgcca ttttttctcc ttggcgcagc 3474901 gtaaaggaaa agttgtgcag cacttggctg ctgttgtcat aagaaaacgt cacatcacga 3474961 aaggccaagg tgacatcttg aagatcgaga atttgatccc ctgattcagt ttgtgacgcc 3475021 tccggctgag gagccacatt gttcatgcgt ctgatagaat cctgatagcc cggcacttcg 3475081 cctaaggcat ccgaaagcgg caaaaaggct tccgtcaacg gaaacaccac tagcacaaaa 3475141 gcggcaatca tcgttttagc gagctcgccg tccgcttgct gtcccgctgt ccaaaacagc 3475201 atcagcaaaa taaggccagc gacaaggcat tgcgcagcaa agtcccgcca tcttgtaaag 3475261 cgttgttttt tccgttcaag ctcaaaccaa tcacgttcct ctttttcata agcatcaata 3475321 aaagcatgcc ggcgtccgct gaacatccag tcgctgacac ccatcacagc atctgtcaga 3475381 cggctgtaca gcacattccg tccgcttttc agcttcgcat tcttcgctct cgtcacgagc 3475441 aaagacacaa ccggaaacaa tacaacaaga acaaacaaat acagcgcaag caatatggca 3475501 aacggccaag agaagaagcc gagcgctatc actgacacag catacaggag caaggctgag 3475561 atcgcaggaa aaatcgtttt taagaaagca tcctgcaaat gctcaatatc ctcagacaaa 3475621 atgccgagca tatcccccgt gcgaaaacgg gaacgcagca tcaaagcacc cggctcaagc 3475681 atattgtaaa ggcggacgcg catgtcagat acgattttca aaatgatgtg atggccgacg 3475741 agccgttcca catatcgcga cacagagcgc gcaatcccaa aggtgcgcac agcgacaatc 3475801 ggcacataaa tgagcagaat gttttccggc cttgtcgccg ctttagaaat caaaaaacct 3475861 gaggtgaaca tgagaaaagc agcagaaaaa atcgtcaccg cacccaaaaa gataaccaga 3475921 acgaacaggc gggcattttg cttgatatac ggcaaaatcc attcttcttt cttcatgctc 3475981 tttcccccag ttgtgccttc acgagtttgg tatacacacc gtttttctcc agcagttcat 3476041 tgtgagtccc aatttccgca accctgcccc cgtcaagcac gataatttcg tccatatcga 3476101 gcatccagtg aaggcggtga gtcgcgagaa agacgagctt atcctcaaat aaatccagca 3476161 tcgtttcttt tatttcatat tctgtttcga tatcaagatg ggcggtcggc tcatccagca 3476221 gcaggatcgg acggtttccc aaaaaggcgc gggccagcgc gacacgctgt gcctggccgc 3476281 cgctgagcgc ccggccgcct tccccgatcc gcccctctaa tccgtcagga aggttgttca 3476341 ccagctccgt cagtcccgct gaggcagcag cacgtgttgt atcctctgcc gaagcgcttg 3476401 gatggtagaa gcgaatgttg ttgccaagcg tatcatcaaa aatgtacgga tgctggggaa 3476461 tgtaaagaag gttcttctgc cagctgccgt cctgcaaatg ggaccggctt gtaccattaa 3476521 cctcaatcat cccgccatcc ggctctaaaa atccgccgag aatatcaatt aatgttgatt 3476581 ttccggcgcc gcttgcaccg ataatgccga tttttttctt gcctttgaat gagagatgaa 3476641 tatcagacac cgaacggccg actgacacgc ctgacagctt cagctcatcc tgatcggacc 3476701 aagcttcgag ctgaagcggc gtctcttctt taaaaccagg ctgcgacaaa atctcttgaa 3476761 tggtttttcc tgcttcctgg ccgttcagcg ttgcatgata atcattcccc acttcccgca 3476821 ccggcaaaaa atactcaggc gccagaataa gcgccgttaa agcagggcca agcaaaatat 3476881 cgccgtcaat gaggcgcagg cccagaaata ctgcgactgt cgccaccgac agcatcgtga 3476941 aaaaatcgag ggcgaatgat gacaaaaacg ccacccggag tgtgctcatc gttgccttgc 3477001 gataccgctc actcacatag aaaatatttt tgctgtgtga cttgctcaaa cctaggaaac 3477061 gcaatgtctc cagcccgcga agagaatcaa caaaatgatt ggaaagtctc tgataggatt 3477121 tccactgacg atccgctttt ctctgcgcga caaggccgag gagaatcata aagatgatca 3477181 gaatcggcat agcagcgact aaaatgatgg ctgatgtccg atcctgaaaa aacacataaa 3477241 tgacaactgc cgcaggcaca atcgccatgc tgaccatttt cggcagaaac agctccaggt 3477301 agcggcggaa ctggctgatg ccttccatcg ccagcgtcac catttgcccc gtcccctctt 3477361 tctttgcaaa gcgggggcct aatcggaaca gctgatcaag aaaacttttc ctcaaatctg 3477421 ctcctgtccg ggcggcgtat tgatagacga ttttctgtcg cgccaccgtc atcccgtgcc 3477481 gggcgataaa agcgatgagg aaaaagccga tcaccggtaa aagggaggta atgcccttcc 3477541 cgttgaacag tccggttacg gcctcactca gccactctgc ctgcataata atggcggctg 3477601 tctgaatcaa cgttaaacaa gtaatcaagg tgagaatccg cttcattcct ttatatcgaa 3477661 acaggtcttt tcccattaat aagtcatagg ctccttatgg ctgacgcgct tccggaagac 3477721 ataatagctc cagatctggc tgccgatgac gaacggcaat agcgttaatg ctgcaattga 3477781 catgacttta agcgaataat ctccagaaga agcgttagct actgttaaat cgtatgcgct 3477841 atgaagcgag ctgaccatta cacgagggaa tagggaaata aagatcattc ccacggtcag 3477901 cgccagacca gcgcctgtca tcccaaatgt ccagccgtct tttttcttac gaataaatac 3477961 agccgcgagc ataaagcaga tgacaatcaa aacagcgagc ggaatggtaa tctcgccgcg 3478021 gcgtgtaaac atgtctgtct gatacgcaga aagggccgcg aaggcaagaa ccgctacaaa 3478081 aacaacaccc attatctttt gcgccatttt ccgggcgcgg ttttgcaaat caccaatcgt 3478141 acgcagcgtg ataaacatta atccatgctg gaagcaaaga agcgttaccg tcacaccgcc 3478201 aagtatagaa tatacattga tataatcaga tacatgtgcg tgaatgttca tgtcggcatc 3478261 aatcggcatc ccgcggaata atgtcgtgaa cagcacacca agcacaaacg gaggaattag 3478321 actgccgaaa aaaacgaccc agtcccaaac ctttacccat tttaaatgat ccaccttgcc 3478381 gcggaactca aacgcgaccc cgcggcccat taacgcaagc agcactatga caaacggaat 3478441 gtaataaccg ctcagcatcg ttgcatacca gtttgggaat gccgcgaaaa tggcgcctgc 3478501 gccagtcaaa agccacactt cattcgcgtc ccagaacggc ccgatcgtgt tgatcagcac 3478561 tctgcgttct aattcattat ggccaagaaa acgggtcgcc atgccgaccc cgaaatcaaa 3478621 gccttccaaa aagaagaatc ctacaaacaa tacagcaacg agtataaacc aaagatcatg 3478681 aagagatgcc atggtatacc tcctgactaa atggatctgt tgatacaggc acatcatgat 3478741 gattatcatg ctccgcacct tttttaatct cacggataaa caagaagaca agcagtgcac 3478801 caagaatcat gtacatcaca ccgaatgcga tgattgagaa taacaaggaa cccgctgtta 3478861 cgttaggcga cacagattga gcggttgtca ttaaccccat aaccgtccaa ggctgacgtc 3478921 cgatttctgt cataatccag cccgcggagt ttgcaagaaa cgggaaggaa atcaacgcga 3478981 tcatgatgcg caaataccat ttgctgtttt caagcttttt acggcggttt aaccaaaggc 3479041 cgcctaacgc agcaagaatc atgacaacac ctgctcctac catgatgcgg aagctccaga 3479101 atgtcgtttt cactggcgga atgtagtcgc cttttccgta tattttttcg tactcagcct 3479161 gaagggtttt catccctttg acacttccgc tgaatttctg ataagccaag tagctcaagg 3479221 cataaggaac tttgatttca tttgagcttt tttcattttt tgtatcgatc gtcgcaaaag 3479281 cggtccaagc agcagggtca ccgctgtctt cccataggcc ttcactggca gccattttca 3479341 tcggctgtga ttccatcaag tgctcagcct gcatgtgtcc gctaaggccg acgccaagac 3479401 cggcacaaag accgacgatc attgcgagtt taaaagattg cttaaagaac ggcacttctt 3479461 ttttcttcag cagtttaaaa gcactcactc cggcaataaa gaaagctcca gtggcaagcg 3479521 caccgaaaat aacgtgcggg aattcaaccc aaagctgagg gtttgtaatc aacgcgccaa 3479581 aatcattcat ttccgcgcgg ccgtttttga tcgtaaagcc gaccggctcc tgcataaagg 3479641 agtttgctgt taaaatccag aaagatgaca tgatcgttcc gaatgatacg agccatatgc 3479701 agagcgcgtg aattttcttc ggcaggcggt cccagccaaa aatccataat ccgataaaaa 3479761 tagattccat gaaaaacgcc aataatgctt caatcgcaag cggagcgcca aatacatctc 3479821 cgacaaaacg ggagtaatct gaccagttca gtccaaactg gaattcttgc aaaatccccg 3479881 ttacaacacc gactgcgaaa tttattaaga ataagtgtcc ccaaaacttt gccattttga 3479941 gatacagctc atttttcttt acaagataaa gagtctccat caacgcaacc ataaacacaa 3480001 gcccgataga catcggcaca aacaagaagt gaaacaacgt tgttgatgca aattgtatgc 3480061 gggctaatac caattcactc atgctttctc ctccatttcc ggttaaaact gttaatttgc 3480121 tcactacttc acaaatagaa ccgagacttt gatcagtaat tcacaaaata gacgaaaaaa 3480181 atattgctca atatttcaca aatgtgtcaa aaagtcatcc aatatgatgc aagattgcca 3480241 gactgaccaa atgacacaat ctctgactgg ttcatattaa gtactttaca acgattcatt 3480301 tcaaaaataa agcctaaaat acctaaaaag tcccgcacta tgtgacggat ttttgtctat 3480361 tttgttgctt atttatgtcg gctgctagga taaatgaccc tttattatcg tacatcaaca 3480421 catcgttcct tgcgaacaaa atgcttgccc ccgccccagc actcgagtct cagcattccg 3480481 tcttaaaccg attttagtca gaatgcctct tttcatttga accggtaaga ggagaaaagt 3480541 tgaatagtaa atttttaata tattaataat ttcaattttt tagtatactt aacatagtga 3480601 acaatttcac tgcatcaaga ataggggagg tttttcaatg ggagagcttc aaacacacat 3480661 gcaattgcaa acggatacaa ttcacgaagg ggttcgaaaa gagaattggt ttgcgaaagc 3480721 catgaatata aaagtaggca tcataccgct tcctgtgtat gccttgctgt ttatattaat 3480781 cactgttttt gttatgcatc acgatgtaaa aagtgacatt ttgacatcca ttgccgtcat 3480841 ggcgtttttc gggtttacct ttgcccaaat cggcaaatcg ataccgattg ttcgttctat 3480901 cggcggcccg gccatcctag ctacttttat tccgtccgct gtcgtgtact atcacctgct 3480961 gcctaatgat atcgtcaaat ccaccacaga atttacagaa aactcaaact ttctatattt 3481021 gtttatcgcc ggtattgtcg tcggaagcat tctcggcatg aaaagagaaa cactcgtaaa 3481081 agcattcatg aaaatcttta ttccgcttat tgtcggttct gtcacagccg ctattgtcgg 3481141 actggctgtc gggacattgc tcggactcgg atttcagcat accctgctgt acattgtcat 3481201 tccgatcatg gctggaggag tcggagaagg cgctatcccg ctgtccatcg gatattctga 3481261 catcatgccc atttctcaag gggaagcgtt tgcacttgtt ctgccatcga ttatgctggg 3481321 cagcttgtgc gcgattattc tagcgggatt gctgaaccga atcggaaaga aaaaaccgga 3481381 atggacaggc aacggcaaag tggaccgctc cgaagaagag tcccctgcgc tggaggaatc 3481441 tcaaagcgga cagcaaatgt tcaacctttc tttatttgcg tcaggcggta tccttgctgt 3481501 ttctttatac ttagtcggca tgctcgctca cgattttttc ggttttccgg cacccgttgc 3481561 catgctgtta ctggctgttc taatcaagct gttcagattg gtgcctgcct caattgaaaa 3481621 tggcgcgttt ggagtgtccc gcttcttttc aacagctgtg acctacccgc ttctctttgc 3481681 gattggggta tccatgacgc cgtgggacaa gcttgtcgcc gcttttaacc tcagcaatat 3481741 tatcacgatt ctgtctgtcg ttgtgaccat gatggccgtt ggcttcttca ctggaaaatg 3481801 gctgaacatg tatccgattg aaaccgccat tattaatgca tgccattctg ggcaaggcgg 3481861 cacgggtgac gttgccattt taagcgccgc tgaaaggctt gagctaatgc ctttcgccca 3481921 ggtgtctacc cgcatcgggg gcgcgattac agtatcctta accttattgc tgctgcacca 3481981 gttttattga tccccgcaag caagttcttc gtcaaacgaa agagcttgct tttttgcatg 3482041 tccatgtttt tgcaagttcc catcccatgc tatagtaata gttggaaata ctagatagaa 3482101 aggaatctgg catgcctatg ggaactcatc tatttctctt tatgcttctc gggctgggat 3482161 tttatttgat atcagcccta gctgcaaaac tcattccggc catagacttc tggattgata 3482221 ttgttctatg ggtcggcgct gcggcttaca tcttctctca tctctcattc atggacggca 3482281 ttgtctcact cgcgacaatg ttctactgct attggaccgc aatggatctc attgtttcag 3482341 agcgtgtgga aaaaccttcg ggagactggc aggaaatcga gcttgccaaa aacaaaacac 3482401 gcctcctgtc agacattacg ctgaccgcca ttgtgtttgc aggggctgtc atttttttca 3482461 tctatggacc tgacacaagc cctctcaaat atgtgatcct tctcggaatg atctccggcg 3482521 gaggggcact tgtgaagcga atactgaatg tttttagcgt aaaggttttt tattcagcag 3482581 ccttagaaaa attgcatatc agctcacact atgaaacccg tacatacccg ctttccgatt 3482641 tgaagaacat tcagcttgaa tcaacagcag atctcttaaa gctccatccg cttctgacga 3482701 tgtattcatc ccgtttagat ttgacaacaa gctttcagca agtcattaaa ctgtctcttc 3482761 ccggcgaaac actgtttctg acggtgaagg aaccgcaaaa atggaaaaca attcttcagg 3482821 aatacacaga tgcagaaaac aatgtggaca atgtgatttc tgttttgccg ttttatcatc 3482881 gaaaaaatgt gaagcggctg ctcggtaagc tttattttgc cgccagcgta aaaggggtat 3482941 ccgcttacgc cttattggtg ctcgcgttat acgcattaca cgcctctcca tgggtcatgg 3483001 ctgttgccgt aatcctatat tgggtattca acatgtatat gtcagaccgt gtgttgcggg 3483061 cggcgatgga cgccaagtct tgtcatcatc cgcatgtaca ggccgcggcc gataagattt 3483121 tcagatcggc cggcatttcc catgtccgca tatacgaaac ggagagtgat gattacaacg 3483181 gaatggcagt aggcatgaat gtcgggaggt caatggtcat cctgacaagc gccacactaa 3483241 cacttccaca gcgtgtcatt gaaggcattc tggcccatga ggcgattcat atcaaaaaac 3483301 gtgacgttct gtcatcacag cttttgcgtt ttctatatct tggagctgtc gtggggattt 3483361 tcctcttgtt tgagcagcat atcacccatc ccgaggccca caaaattgcg ctttgggctt 3483421 tcattatggc aatcattatc ctattccagc tctatcaatc cttttgttca caatggatgg 3483481 aggtgcgtgc tgacaacctt ggcgcatcat tgctggacgg cggttacaaa caaatggctg 3483541 aagccttgag aatcttggcg gttcggcaag atgaggatat acagaaacaa agtgcctata 3483601 gctctgaagc aggtgaagac gagcttcaaa ttgattctct cacccgtgat aaaagctggt 3483661 ttttcagatt gattgatttt cagttcgctc ctcatcctcc tatgtattgg cgtgtcggca 3483721 ctttattgtc aaacaaagga catggggtgc taaagcgctg gctcagagac cgactgaaag 3483781 aatcgatcac tttgaaatga aaccggtcag cgtttcatcc gtataacaga tatggtgaaa 3483841 aaagggagtg acgcgaagtg attgtgatca tcttattgtt tatatctatt attgtttttc 3483901 tttcagtcat tcagccgcag ccctcgaaaa acaaaagccg ccagcaggcg gacagcgggt 3483961 atttcggtta ttcagatcat agctcacacc atgatggatg cagcagtgac ggaggtttca 3484021 gcgattccgg ctgtggcggc ggagggggcg gcgattaaac gccgcctttt tttatttcat 3484081 tgattcgatg tacgcaccaa aagccgagcc tgacatgcct ggggacacgc gcacacgatg 3484141 gagggcatac attccctggt ctctcgaagc cgcgcccggt tctgtcgtca cgcccatttg 3484201 atagcctgtt ttttcagcgg ccttcagcgt ctcctcattg tagcgcccta ccggatagct 3484261 gatgatggtg gtttgctgat gaaacatgtt gtcgaacagc tttttcgaat cagccatctc 3484321 actttgctgc tgttgaggcg ttaatccgtt cagctcaagg tggtcaatcg tatggctttc 3484381 aatcgatatg ccgtgctgtg ccatttcctt catttgttcc tctgtcagat ggtgcttatg 3484441 tccgatcgat ttgccgatca taaaaatcgt tgccttcatc ccgtactttt tcagcaccgg 3484501 atacgcatct tgataattgt cggtgtaccc gtcatcaaat gtgatcagca cgcacttctc 3484561 actcggtttt ttatcctgcg tcagcatgag agatgcctct ttcggcgtta atgtctgata 3484621 gccgttatca tgaagccact tcatatgcgc ctcgaattct ttctttggca cacggaggct 3484681 gtttcctgaa gaaatgctgt ggtacatcaa aatcggcagc tttgccggtt tctctgtttt 3484741 gatccatgcg gatgtatcgt cttctttttt ctgaacttgt actgcctttt tttccggttt 3484801 cttttgttcc gcttttggca tcggctgctc tgcattcgcc tcttgatcag cacaagccgc 3484861 aagagccaaa cagctgccca aaagaaagat gcttaaaaac aatcgtttca tcgttctcct 3484921 gctttctgtc tatttcttcc tcctttttca tcggtttgat tctgagattt tcaatagcaa 3484981 aaaaccggac atgtctccat gtccggtttt tttgatctta tcggattctc acttctgtct 3485041 cactgtcaaa gaaatggcct ttattcatat caaatgcaac cgtcagctca tcgcccgatt 3485101 gaatatcgag gcgggcgtcg atccgcgcaa taaagtcttg gttgtctatc tgcgaataaa 3485161 tcataatttc agaaccgagc agctctgcaa cattaatttt cgccttaatc gaagagttct 3485221 tatatgattc cacgacaatc aattcatcat gtatatcctc aggacggatg ccgaagatga 3485281 cctctttgcc gatgtagcct ttttcacgca gcactttcat ttttccttcc gggacggtta 3485341 atgccgcaga accgattttg attaagccat ccgtgagctt tcctttgaaa aaattcatcg 3485401 ccggtgatcc gataaacccg ccgacaaaga cgttttcagg gaattcatat acatccttcg 3485461 gcgtcccgat ctgctgaatt ttcccatctt tcatgactac aatccgtgtc gccattgtca 3485521 gcgcttctgt ctggtcatgc gtcacataaa tcgttgtagt ctgcaatctc tggtggagct 3485581 taatgatttc cgcccgcatt tgcaccctca gcttcgcgtc caggtttgac aaaggctcat 3485641 ccatcaggaa cacctttgca tcccgcacga ttgcccggcc cagcgcaacc cgctgtctct 3485701 gtccgcctga cagcgctttc ggtttacggt gcaaatattc ctcaagcccg agaattttag 3485761 cggcttcttc gactcttttt ttgatttcag gcttcggcat tttccgaagc ttgagcccga 3485821 acgcgatatt atcgtagacc gtcatatgcg gataaagcgc gtagttctga aataccatcg 3485881 cgatatccct gtcctttggc gctacatcat tgacccgttt tccttcaata taaaaatcac 3485941 ctttcgaaat ttcttcaagt cctgcgacca ttcgcagcgt cgttgatttc ccgcagccgg 3486001 acgggccgac gaatacgata aattccttat cggcaatatg aaggttaaag tcatcaaccg 3486061 ccggttcctt ctgatcataa aatttataaa tgtgctccat ccgcaattca gccatctaac 3486121 atcccccttt gttattgtaa acgctttctt atattgagtg taacagcaat tccctctcgc 3486181 taaaatgggc agcgttcata aaatcaccca gccatttttc gtgcatattt ccaatttatt 3486241 ctgaactttc attttgcagg cagataaaat aggcaagaag cgcgcctttg tacgatttga 3486301 tatctatccc tgaccgctca ataaatttat caatccgata ttgcaggctg ttgcgatgca 3486361 gatgcagctt tttcgctgtt aatgtgacgt ttgagttgtt ttcaataaac agcttaatgg 3486421 tcttccttag ctcagattca cttccaaata aaagctcagc ttcttcagag agcagtgttt 3486481 ccagtttttc tttttctgtt tctaataata gaaaaggaaa gatcatctca aaggtcacac 3486541 tctgcacctg aggcagccgt ttttcagcaa acaggaaata cgcctgttca cgagcgtaat 3486601 gttttcgcag acactcatcc ggctcgtaaa atcttccggc gtaaaaacgg acactgaagt 3486661 agaaatcact ttcaagaacc ttagcgagcg attccagttc gtccttctcc gccgccgctt 3486721 cactttcctg ctcgacaatc acacctctgt cctcatggat ccacacaatc acaaaagaca 3486781 ccggccaaaa atggcgaacc gcttccgtaa aggacgtcct ttctattttg ccgaataaat 3486841 gaaagtgaac aaatctcgtc cgtttcttta tatacgccgg caattcccct ctggaaaaaa 3486901 ggaacgaaaa ccacttgttt tcctcaggtg atttcataga cagttgattg ccctcatccg 3486961 caggcgtcaa aaatgactgc agcaccaata cttctttttc actgatctct gttttcggaa 3487021 tggagatata tctctgattg ctctcatcaa aaaaacatag acagccttcc cttatgcaaa 3487081 gctcctcaga cacaatcgaa ccgggataaa tagccagcag cgatttcata gagtctcctc 3487141 tcttatgtaa ggatctgtat attcagtata aggcgaaaca cacatgttct ccactaaaaa 3487201 agagtatatc cggtatagat agacgagaaa ctgaaaggga aacctcattc gtttacatat 3487261 tggcttcagc ggaaatagaa gaagacatgc aggaccaaag gagggtcatc ttatgagttt 3487321 cgaaacgtta aacaaaagtt ttatcaacgg aaaatggact gggggagaaa gcggacgtac 3487381 ggaggacatt ttgaatccgt atgaccagtc tgtgatcaca acagcatctt tggcaacggg 3487441 caaacagctt gaggatgcgt ttgacattgc acagaaagcc caaaaagagt gggccaagag 3487501 cacgacggaa gaccgaaaag ccgtgctgca aaaagcgcgc ggctatttac acgaaaaccg 3487561 tgatgacatc attatgatga tcgcccgcga aactggcgga acgatcatta aatcaacaat 3487621 cgagctggaa caaacgattg cgattttaga tgaagccatg acgtatactg gtgaattagg 3487681 cggcgtcaaa gaggtgccat ccgacattga agggaaaacc aataagattt accgccttcc 3487741 gctaggtgtc atttcatcga tttctccatt taatttccca atgaatctat ccatgagatc 3487801 cattgcgccc gcaattgcgc tgggtaacag cgttgttcac aagcctgata tccaaactgc 3487861 tatttccggc gggaccatca ttgcgaaagc gtttgaacac gccggtcttc ctgccggtgt 3487921 ccttaacgtc atgctgacgg atgtaaagga aatcggggac ggcatgctca ccaatccaat 3487981 cccgagatta atcagcttta cagggtcaac agcagtcggg cgccacatcg gtgaaatcgc 3488041 cggtcgcgcc ttcaaacgaa tggcacttga gctcggcggc aacaatccat ttgccgttct 3488101 ttcagatgcg gatgtcgatc gtgctgtgga tgccgcgatt ttcggaaaat ttattcacca 3488161 gggacaaatc tgtatgatta tcaacaggat catcgttcat caagatgtat acgatgagtt 3488221 tgtagaaaaa ttcaccgccc gtgtcaaaca gcttccgtac ggcgatcaaa ccgatccgaa 3488281 aaccgttgtc ggcccgctga tcaacgagcg ccaaatcgag aaagcgctgg agatcattga 3488341 gcaggcaaag acagacggca ttgagcttgc ggttgaagga aaacgcgtcg gaaacgtgct 3488401 gacgccgtac gtctttgtcg gtgcggacaa caacagcaaa attgcccaaa cggagctgtt 3488461 tgccccaatc gcaaccatta ttaaagctgg cagcgaccag gaagcgattg acatggcaaa 3488521 tgatactgaa tacggcctca gctctgcggt tttcacttct gatttagaaa aaggcgaaaa 3488581 gttcgccctg caaattgaca gcggcatgac ccatgtcaac gaccagtccg tcaatgattc 3488641 gccgaatatt gcctttggcg gaaacaaagc aagcggtgtc ggccgtttcg gcaatccgtg 3488701 ggtcgtcgag gaatttaccg tgacgaaatg gatttcgata cagaagcaat accgcaaata 3488761 tccgttctaa atgaaaaaat ccctctgttt caagtacaga gggatttttc tttatttaga 3488821 tatatccaca aacccttcgc caaacacatc gcgtacgtca tgtacgatca caaacgcttt 3488881 tttgtcgcag cttctaatga tttttttcag catagacagc tcctgtttgt taatgacgat 3488941 atacaaaatc tcttttgact ggcccgtata atttcccttc cctgataaaa tcgtcacgcc 3489001 ccgatccatc aaggtattta cctgctctgc aatctcactc ttattttctg aaatgaccgt 3489061 aatggctttt ttcgtattca aaccttcaat aatgaagtcc atcactttgg taccgatata 3489121 cagcatcacg atcgtaaaca tcattttttc tgcaccaata ataaaataag agctaaatac 3489181 tacgattaaa tcaaaaaaca agagtgcata gctgatattc cagtctaaat atttattagc 3489241 aattctggcc agaatcgcgg aaccggccgt cgtcccgccg acccggataa tcatgccgat 3489301 cccgactccg gcaaatacac ctgcgaaaat cgtattaatg atcaattcat cagacggaat 3489361 gctccaccca tgtgtcagat gaagaaaaag cgaatttgcc gcaaccgcaa tgatcgtata 3489421 aaccgttgtt tttccatcaa gaaacttgta gccgattaaa agcaaaaacg catttaagat 3489481 aaagttcgtg acaccaggag accattgaaa cagataatac aaaatcagcg taatcccagt 3489541 gactccgcct tccccaagat cattgggaat cgcaaataaa ttaaccgcaa gcgcgaagaa 3489601 aaaagcgcca atcacaagca taagtacatc cagcattctc tttttcatca cgaaaacact 3489661 ccttttcatt gttctgttct agcaaataaa aaaacccagg agaacgctct cgaaaaagag 3489721 cagaaactcc tgggctttta tcccaccgtg tcataacagc caagctgcta tgtgttttct 3489781 ctcggtcaca gtccaatttg cattgcggaa ccctagaaaa ccactgtttt tatcatatcc 3489841 ttttcacttt ccaatattag cattataagg gacggttcga attggttcaa ggggtatttg 3489901 cggagttttc atcagataag ctggaaaaaa atacgattta tctattaaaa aagaacagat 3489961 ataaccgata agaaaaaaag catatatttt acaagcgaat gtaactataa atgataataa 3490021 ttataagaaa ttcataattt tatattgact aagagaaata atataggcat tatagtacat 3490081 atgtttcgta cattttatta cataggagga aatataatgg caggaaaact agtaccctgt 3490141 aaagcttgcg gtcaagaaat tgcaaagggt gtaaaaaaat gtcctaactg cggtaaggat 3490201 caacgtaact tttttatgcg acataaaatc attacgttta ttctcgcagt tgttgtcatc 3490261 attattatcg gtaatatgat tggcggcgga ggcggctcag aagccacttc caaaacatca 3490321 agcagcagca aagcagaaac tgaaaaaaca tacaatatcg gtgataccgt aaaaactgaa 3490381 aaaactgaag tgacggttac gaaggtagag gacagagata ctgtcggtac tcaatatgtt 3490441 gaaaagaaag catctgaggg aggtacaatt gtagctgttc aatatacaat taaaaacgta 3490501 tctaaaaagc cgattagctc tttttcaatt ccaactgtta aattagttga tgctgatggt 3490561 acttcttatg attctgatat tgatgcttct gtaaactatg caactgagac aaaagttgat 3490621 aactctaaaa ttttgagtga tctaaatcct aatattaaag taacaggtgt aaaagcattt 3490681 gaagttgaca aggaagctta tgcaaaaggc acttggaaac taaaattcag taatgatgtt 3490741 attgtgaaaa tcaaataaca gctaacaagg gtgcctgttt aggcaccctt gttctttaaa 3490801 aaaggccttc tcaattgaga aggcctccat tcttattccg cactcttata cccattcaca 3490861 ttagaagact gccatctcca ggaatcagca cacatttcct caaggccgcg tttcgcttcc 3490921 cagcctagtt ctcgcttggc tttcgcagga tctgcaaagc atgtggcgat gtctcccgga 3490981 cggcggtccg caaaacggta tggaacctct ttccctgaca ctttttcaaa ggctttgacc 3491041 atttccagca cgctgtagcc tgtgcctgtt ccaaggttgt atgcatcggc tcctgtagag 3491101 ttcaatactt tttccagcgc cttgacgtgg ccttctgcga gatcaacgac gtgaatataa 3491161 tcgcgtacgc ctgtcccgtc ttttgtcgga tagtcatttc cgaatacgct taattgctcg 3491221 agcttcccga ctgctacctg tgccacatac ggcataaggt tatttgggat tccgttcggg 3491281 tcttcaccga tccgtccgct tggatgcgcg ccgaacgggt taaagtaacg aagcagcgca 3491341 acgctccact cattgtcggc tgtatgcaaa tcacgcaata tttgttcaag catgagcttc 3491401 gtctgcccat aaggatttgt cgcgcctaat ggaaagtctt ccgtaatcgg cgatgtttcc 3491461 ggaacgccgt atactgtcgc agatgaactg aatacgattt tcttgacgcc gtatttctcc 3491521 atggcctcgc ataaaataaa cgttcctgtc aaattgttat gataatattt gaggggaatc 3491581 gccacagatt cgccgactgc ttttaaccct gcaaaatgaa tcacagcttc gatttcattt 3491641 tcagcaaaaa cggaatctac cgcttcccgg tccaataaat ccgcttcgta gaacgttaaa 3491701 tcttttcctg taatctcctt gacacggttc agcgcttcag ctgaactgtt ggacagatta 3491761 tcaagaacaa caatctcgta gccgctgttc aatagttcaa cacatgtgtg gctgccaatg 3491821 taaccggcac cgccagtaac aagtattgcc atgatgtaaa ccctcctaaa aaatgacctg 3491881 ttttcattat atagtgttta gaaccggtcc acatccattt ttaagaagtt taatcgttta 3491941 ttaatagttt tttcatattt tttagcttaa acccttgcca gcaattcgat agaggtttca 3492001 gcaagaatgt gctctttcat ttcttgatag agctcattca agtaaaagcc cggctgaaga 3492061 ttcagctcag catctaaagc atagaccgtc aatgtatacg catgatcctt gtcaggcggt 3492121 gtcggcccgc aatactggtg aatcaccttt ggatcgttgc ttcccgcaag cggtgaagca 3492181 aagctgtttt gcccttgtat catcaagtcc tgtctttcct cactcgcatg ttcaggaagc 3492241 tctccgatgt aagccggaat attagccgct gtccagtgaa tccagctgaa tccgcatacg 3492301 ggaatggcgt catgatcgat gaaagtaagt gcgagcgtct ttgctccgga cgggatgtca 3492361 tcaaaatgaa ttggaaagga tacaaatggg tttccttctc tcttatattt ttcatccgcg 3492421 tattttgaat acttgtcatg taaatatgga tttgcttcta cgtatatgtt catatgaatc 3492481 cctctctcta ttttctcgtt ctataggtat actaaacgaa tcgatgtata atcagtgata 3492541 aacaaatacg catgtaaacg taacaatttg ttatggataa cttgcagtga aggagatatt 3492601 tcatggattt aaaatggctg caaaccttta ttgccgcagc ggaatcagag agcttcaggg 3492661 aggcggctga gcatctgtat ctcacacagc ctgccgtttc tcagcatatg aggaaattgg 3492721 aagatgaact ggacatgagg ttgtttttgc atagcggaag acgagtcgta ctgactgacg 3492781 aaggcaggct ctttttgcct tatgccaaag aaatgatcca tgtttaccaa gctggaaagc 3492841 agaaagtcag tcaatggaaa caggggtaca gccgatcact cacgctggcc gtacacccct 3492901 acattgcgtc ctatatcttg cctcgctttc tgccagccta tatccaaaaa catccgcatg 3492961 tcgagctttc aactcatgtg gctggatctg acgctattaa acaagcggtg gaacacaatg 3493021 aagctgatat tggtttgtcg cggaaagacc cgaacaccaa cactctttat tatcagcata 3493081 tatgcgaagg tacgctttgt ctggcggctc ctttccaaga aagcagaccg gatgctgcat 3493141 ccgtcttaac ccgctatcgg ctgctaacgc atgatcatcc gtcatatggg gatgcctttt 3493201 tagataacat ccgatcacat tacccgtatc ttcaaatgat ggctgtcggg cagacggata 3493261 cggctgtcca catgatgaaa gcgggaatgg gggcatcttt cctccctacc tacattatca 3493321 aacaggaaga agccgaaaaa aagctgatgg ctgtcagcac gcctgcacat ctagaattgc 3493381 ctgcgtccca aacgtttatg atgtggaaaa gaaacagcga agacattcag cattttcacg 3493441 ccatgttaca tgactttatg cagcgcgaac aagtatagag ctgaaaaatc aatctgccgg 3493501 ttgacgtttt tctttcctat tttcgctatg cttaatgcag aaaggatttg atgacatggc 3493561 gatgagccct tatattttta ttgtattgat tcttattatt ttatcgatgt atcgagaaag 3493621 aacggtaaag cccgggaagt tgctgatcat tccactgttg ctcttatggg gcgtatctgc 3493681 atcgtttcag ccggcgtatt ttcattccgt attacatgtg gcgatcagcg gcattttatt 3493741 actgatcggg ctggcctgcg ggtttggcat tgggaagatg gtaaatgtac ggattcaccc 3493801 ggaaaccgga aaggtcactt cacgcggctc acttgggagt gttatcctca ttctagtgat 3493861 actttctttg cgcatggccg cgagaacatg gctgcctgag agcaacgaga tgtttattgc 3493921 cattattcat tctatgttct tcgttcccct cggcaccatc acagcccgca acatcatgct 3493981 ttacaaagca tacagacgac tgaccgctgg caaagtatcc attcaataac cgaaagaagg 3494041 accagcatga acggacaaac tccggctcgg cactactaca agaagcttgt gccgagcctt 3494101 attctcattt tgaattgcat acaattttta tctcatccaa ctaaggctga tcccattttg 3494161 ttagcatttg tatttgcggt atacttagca ttcatttgga tcattcccta tgtggcatcc 3494221 actgctgtta gtttgagcat attcatcgga ctctggctcc tgaccgattt cttttgggct 3494281 gtttccggcc aagagcaggg tgccgcctat tttttgattg tatttttaat gatatatgcc 3494341 gcctttagac tcccttcacg gctatccttg atcttcacag catgtttaat tggaggcaac 3494401 atattactcc tatcctcaca agggggaagc ttgaatacca tcatcagcaa catctcgatc 3494461 atgctcggtc tgtacgtcct cttctcctcc atgcgtttca gacgagaagc gagaagggag 3494521 gctgaacgga atcatgctga attggcaaaa atgcatgtgc agctggagca tgctcataaa 3494581 gaactccaga aagcgcatgc agagctgcag gaggcttctg ttctttcatt aaggtacgcg 3494641 gtccttgagg aacgtacaag aattgcccgc gacattcatg acagcatcgg tcacgagctg 3494701 acttctgtga ttgttcagct tcaatccctt ccctatatcc ttaaaagcag caaggaggat 3494761 tcagaaaaag tcattcaaaa tgtactgagt gtcgccaggg agtgtcttca agaagtgcgg 3494821 tctgttgttc accaaatggg ccgtagtgaa tcgatggtgg ggcttaccgc tttgcggggg 3494881 ctcattcatc aagtggagga acggagcggc ttgcacgttt ctttagatac tgccggactg 3494941 tcagaagagt cttggcctcc aaacgtgagc gaaacgatct accgcatctt gcaggaagcg 3495001 ctgaccaata tcattcgtca cgctgacgct tctcatgcgg cggccgtcat ttctaatgac 3495061 aagtcccatc tctatgtcac aatcaccgac gacggacaat tcaccggcag ccttacttat 3495121 ggatttggcc tgacaggaat gaaagagcgc gcagaaaaag caggcggttc ccttactttc 3495181 agtgccgtac agccgagcgg cctgaaaatt gagctgtcat tgccgctcat gacaacgaat 3495241 aaggagcaaa aagatgaaca aagataaaat acgcgtagcg cttgccgatg atcagccgct 3495301 tgtgcgtgaa ggcttccgct acgtcatcaa cgcacagacg gatatgacgg tttctggcga 3495361 ggccggcgac ggtcacgata ttatagcact cgcaaaacaa acaaaacccg atgtcatcct 3495421 catggatgtc cagatgccgc gttgctcagg catcgaagcg gcgaaagaca ttatgtccgc 3495481 acttccaaat acaaagatag tcattttaac cacctttgac acggaagaat acgtatttga 3495541 aggcatccgt gcgggcgcag tcggctatct gctgaaggat acacttcctg aggagttgat 3495601 agatgcgatt cgcgctgcgg ccagaggcga ggcgattttc cgtacagtca cagctgctaa 3495661 aatcatcagt gagacatttc gggcgaaaca gcaaactcat gccgaagaac tggcagagcc 3495721 gttcaccaaa agagagcttg aggttcttca gcaaatggcc tacggactga gaaatgagga 3495781 tattgctgaa aagcttttcg tcagtgaaag cactgtgaaa acccacgtgc accgcatcct 3495841 gcaaaaatgc aatgcccaag accggacaca ggcagtcgtt tttgccattc gaaacggtat 3495901 tgtgcaatag aaatctctca tcccgccatg ctaaaataag acaaaggaga tgattggaaa 3495961 tgaaagaaga aatcattgaa cggtttacta catatgtaaa agtcgataca cagtccgatg 3496021 aatccgttga cacttgtcct tccacacccg gccaattgac attaggaaac atgctagttg 3496081 atgaattgaa gtccatcggc atgcaggatg cagccattga tgaaaacggc tatgtcatgg 3496141 caactcttcc ctccaatact gaaaaagacg tgccgacaat cggctttctc gctcacgtcg 3496201 acaccgctac agactttacc ggcaaaaatg tgaatccgca aatcatcgaa agctatgatg 3496261 gaaaagacat cgttcttaac gaacagctgc aggtcaccct gtcacctgat caattccctg 3496321 agctgtccgg ctataagggc catacactca tcaccacaga cggcaccacc cttctcggcg 3496381 cagacaataa ggccggtatc gctgaaatca tgacagccat ggattacctc atcaaacacc 3496441 ctgaaatcaa gcacggcaca atcagagtcg cctttacgcc tgatgaagaa atcggaagag 3496501 ggccgcacaa atttgatgtg aaacggttca atgcatcctt tgcctacacg gttgacggcg 3496561 ggccgctcgg cgagcttgaa tatgaaagct tcaatgccgc tgccgcaaaa attacgatta 3496621 aaggcaacaa cgtacatccc ggaacagcta aaggaaaaat gatcaactct gcgaaaatcg 3496681 cgatgaagct gaacagcctg ctgccggcag acgaagcgcc tgaatatacg gaaggttatg 3496741 aaggcttcta ccacctgctg tcgattcaag gagacgtaga ggaaacaaag ctccactaca 3496801 ttatcagaga ctttgacaaa gagaatttcc aaaacagaaa agaaacaatg aagcgtgccg 3496861 ttgaagaact tcaaaacgaa tacgggcaag accggattct gctggatatg aacgaccaat 3496921 actacaacat gagagagaaa attgaacctg tcatcgaaat cgtcaacatt gccaagcaag 3496981 cgatggaaaa cctcggcatc gaaccgaaga tttcccccat ccgcggcgga accgacggat 3497041 cacagctgtc ctacatgggg cttccgacgc caaacatctt tacaggcggg gaaaacttcc 3497101 acggcaaatt tgaatacatc tcagttgaca acatggtcaa agccgtaaat gtcatcgttg 3497161 agattgcaaa gcagtttgaa gcgcaagcat aacgccaaaa gccagtccaa aaaaggactg 3497221 gcttttttgt gtgaaaatga aacattttaa acacgtcctc cgtaaaacaa gtatcaacaa 3497281 atgaggagga aaaacaatga caaaacatgc aatcgctgcc aagagtctct tgaaaaaatg 3497341 gatcatttcc aggccgctta acatgaaaaa gaaatccagc ccatttcaaa aaatcagaaa 3497401 aatgttcaaa cgcttcttca aataaaacat caaatcccct aaatacaatc cgtattcacc 3497461 cgtaccgccc aaatgctccg taatttgggt tttttgtgtt caattccgca aaatagggta 3497521 taaaccaaac aagcaagaaa acagcaccca aaaacaggta attcgaatta cgtaaactta 3497581 ggttaaaagt tatataaagg aatttatttt atcgtcgata gtaactatag aaccaatcat 3497641 caacaagagc aaacagcgta attcaagact attttcaggt catcaggtaa tactgtttta 3497701 gagggacagt ttcttgttat ttattgattt agaatttttt gaatactttt tggcatttta 3497761 tccgtacaat agagagtacc aaaacttttt ttgggaggta tgtaatatga tcctatttat 3497821 tatcatcgca ttatgcggct atcttctttt ttctttcagc aaggacaatc gccgcaaacc 3497881 gcaaaagaca agccctctgc cagcagccgc acctcatcac aacaacctaa tcgaccttga 3497941 cgccatccgc caaaaacgcc ggatgcatct ttcctaattc tatatttcaa acgaaaaggc 3498001 tgctgaatca cgcagccttt taaaattgtt ttgatttaga gcctgaaacc ttttcgccac 3498061 ctatccgtaa tttcatacaa ggcaaaccca aaggagactt cagcaatgat cgagttattt 3498121 atgaaacaaa aaatgttctc atttaaagat gcatttcaca tttatgaccg ggatgaacaa 3498181 gaaacattca aggtggaggg gcgttttttc tcgttaggag actcattaca aatgacagac 3498241 tcatctggga aaacgctcgt ttccatagaa caaaaactaa tgtctttatt gccgcgctat 3498301 gagatttcaa ttggcgggaa aacagtttgt gaggtaacga agaaagtaac gttttccaaa 3498361 ccgaaatttg tgatttccgg gcttaactgg gaaatagatg gtgatttatg gagggatgaa 3498421 ttccaactga cggacgggga aaatgtccgg atgtcagtga gcaaaaagtg gctcagttgg 3498481 ggtgattcct atcacttgca gattgcatac gaggaagatg ttctgatttg cactgccatc 3498541 gctatcgtgc ttgatatggt tttatataac gatgaagatg aaagtatttt ctaaaaagca 3498601 ttgacaattg atccaaaagt aataatatta agataattga aatctgaata tgaagttgta 3498661 ccttatcaag agaggtggag ggactggccc tatgataccc ggcaaccgct gtttcaaaca 3498721 gaatggtgct aaatccttaa gaacattgcg ttcttgcaga tgaggcggag atttgatcgt 3498781 tcaagctctt ccttacacaa aggaagagct ttttacatgc ttaatatttc agaaaagagg 3498841 cgaataacat ggctcaacaa acgaatgttg caggacaaaa aacagaaaaa caacgcaaag 3498901 cacctttccg cgccgatcat gtcggcagct tgcttcgttc cgttccggta aaggaagccc 3498961 ggcaaaaaaa agcggctggt gagatgacag cggaacagct tcgtgatatc gaaaatcaag 3499021 agatcacccg catcgtggaa aaacaaaaag aaatcggtct cgatgtggta acagacgggg 3499081 aattccggcg ttcctggtgg cattatgact tcctggaagg gcttgacggt gtggaaccgt 3499141 tcatcccggc tgaggggatt cagttccata acacaaaaac gaaagcgcgc agcatcaaag 3499201 tgacgggaaa actcgatttt acgagccacc cagcgctcgg tgattatcaa tttttacatg 3499261 agattgccgg taacgcgacg ccaaaattga ccattcccag tccaaatatg ctgttttttg 3499321 gcgaaaaggc ggataaaggg atttatgacg atcaagagga atactttcat gatatggccc 3499381 aagcgtacaa aaaagcaatc aaagccttct atgatgctgg ctgccgttat ctccagcttg 3499441 atgatacgtc atggtctctc ttctttgagg acaaaggcag agaggttgtc cgggcgctcg 3499501 gcggtgatcc agaaacattg ccagccatat ttgccaaaac aattaacgat gccgtcgcag 3499561 accggcctga cgatttaacg atcacaatgc acatttgccg cggcaacttc cgctcaacct 3499621 gggcggcatc aggagggtac gacgctgtag cggaaacgat tttggacggc ttaaaccttg 3499681 acggcctttt cttggaatac gatgatgacc gctccggaaa ctttgatccg ctccgttttg 3499741 tgaagcgcaa ggatctgcaa attgtgctcg gcttgatcac atcgaaatac ggcgagcttg 3499801 aaaatcctga ggatgtgaaa cgccgtatca atgaagccgc gcgttttgtc agcttggacc 3499861 agctatgcct gagcccgcag tgcggtttcg cctctacaga agaaggcaac cttctgacag 3499921 aggagcagca atgggcaaag ctgcgccatg tcatcgacat tgccaacgat gtgtggagat 3499981 aatctatcat tgacagaaat agaaaatgtg tgaataatag atactatcag aaaatttaat 3500041 aaaaaggttt tccttatcaa gagaggtgga gggactggcc ctgcgatacc cggcaaccgc 3500101 tgtttaacag aatggtgcta aatcctttag agcaatgatt gctcttgaag ataaggttga 3500161 gattgtcacg caagctcttc cttatccaaa ggaagagctt ttttatattt gaatggaaag 3500221 aaggaatgga caacatgtca caacaaacaa cacccgcaga acaaaaatca cttcaaagaa 3500281 aaaaaccgcc gtttcgcgcg gatcaagtcg gaagcctgct aagatctgag cccgtcaaaa 3500341 aagcgcggct gcaaaaagcg gccggcgaaa tgaccgctga gcagcttcgc caaattgaaa 3500401 acgacgaaat catccgcatt gtggaaaaac agaaggaaac cggcctgaac gtcgtgacag 3500461 acggtgaatt ccgcagagca tggtggcact ttgatttcct ggaaaactta gatggcgttg 3500521 agccgtttac tcctgagcaa ggcattcaat tccataacgt acagacaaaa gcacgcggca 3500581 ttaaagtcac aggcgatatc gacttttcaa ctcacccaat gcttgaagat tactcatttc 3500641 tccatagcat tgccggtgac gcgacgccaa agatgacgat tccaagtccg aatatgctgt 3500701 ttttccgcgg aaaactggaa aaggatgaat acaaaaacga ttatcaactt ttccagcacg 3500761 atgtatccaa agcatataaa aaagcgattc aagcgtttta tgacagaggc tgccgctacc 3500821 tccagcttga tgatacagcg tgggccgttt tcttatcaga aaaaggctta aaacaaatcg 3500881 aagcgttcgg aacaacgcct gacgagcttc gccagctgtt tgcgaaatcc attaacgacg 3500941 cgattgcaga ccgcccggat gacttgacgg taaccatgca tatttgccgc ggcaacttcc 3501001 agtccacttg gacagcggaa ggcggctatg acgcagcagc cgaaaccatt tttgacggct 3501061 tgaatcttga cggacttttc ttagagtatg atgattcacg ctcaggcgga tttgagccgc 3501121 tccgttacgt aaaacggtct gatcttcagc ttgttcttgg cttagtgaca tctaaattcg 3501181 gtgagcttga aaatccggat gacgtgaaac gccgtatcga agaagcgtcc cgttatgtaa 3501241 gcttagacca gctttgcctc agccctcaat gcggattcgc ttcaactgag gaaggcaaca 3501301 agctgactga agaacagcaa tgggcgaagc tccgccatgt ggttgagatc gctaatgatg 3501361 tttggaaata agcaaagaaa aaaacacact tgattcccta gcggagcaag tgtgtttttt 3501421 atgtcattgt gcggtgtagc ccccatcaag gacgacagcc tgcccagtga cgcccttcgc 3501481 cttctcgctt gccaaaaaca cggcataatc cgcaatttcc ttgacggaaa gcagtcgctt 3501541 ttgcggcaca agcggaaaaa tgacttgttc aagtacagag tcgtaaggga catttctagt 3501601 tttcgataga tcgctaagct gattgcgtac aagctgggta tcgacataac ccggacagag 3501661 cgcattgact gttatgccgt ggggcgcgcc ttccagcgcc cctacttttg tgagtccaat 3501721 gacgccgtgc ttggcgctat tataagcgga tttccctgca aagcccacta atccattaac 3501781 agacgcaata ttaatgattc tgccaaactg ctgttttttc atgatcggaa aaacatgctt 3501841 cattgcaata aagggagccg tcagcatgac cttgatcagc tgttcaaagg tgtctgtcgg 3501901 aaactcttca atcggagcga cgtgctgaat accggcattg ttcaccagaa tatccaagcg 3501961 gccgtattgt ttttggatga cgttcaccgt atcagcaact tgcgcttcct ttgtcacatc 3502021 atacggaatg gccgccgcgt caaagccttc ttctgcaagc ttggaggctg ctttttcaca 3502081 tgcttccgga cggaggtctg aaacgatgac gctggcacct tcccgggcga attctcttgc 3502141 gatttcgaat ccgattccgc cggcagcccc tgtcaccaaa gcgacttgtt ttctcatgtc 3502201 aaacaccttc ccattaagaa ttgagtacag actggcttac agcgaaatca gcttctgttt 3502261 tttcataaac ctcttcaatt gtgacaccat cctgaagctc cgtcagtgtc atgcggccgt 3502321 tcacaaaatc aaatacagcc aaatccgtaa tcagcctgtg tacgactttc tggcctgtca 3502381 gcggaaggga gcatgttttt ttcacctttg attcaccatg cttattgacg tgctccatga 3502441 tgacaacgat tcgtttcgcc ccgttgacga gatccatggc gccgcccatc ccttttacca 3502501 ttttgcccgg gatcatccaa ttggccaaat ccccctgctc cgaaacctcc attccgccga 3502561 gaatagctaa atcgatatgc ccgcctctta tcatcgcgaa tgactcagcg ctgtcaaaat 3502621 aagaggcgcc tgtcacttca gtgatcgttt cctttcccgc attgatcaaa tccgcgtctt 3502681 ccgttccttc cagaggatag gggccaattc cgagcaagcc gttttccgac tgaagcatga 3502741 cgtgaacgcc atcgggtatc tcatttgcga caagcgtcgg cattccaatc ccgagattca 3502801 cattcatgcc gtccttgatt tcttgtacag cccgtttgac cattcgtttt ctcgcttcct 3502861 tcacttggcc tcaccctttc ccgatgcttg ctgaactgtt cgtttttcaa tccgtttttc 3502921 ttggctcgcg ccaagcacga catgctgtac gtaaattccc ggcgtatgga tgtgatctgg 3502981 atcgagctct cctgcttcca cgatttcttc cgcctcggca atcgtgatct tgcctgccat 3503041 ggcggcaatg ggattgaaat ttctcgccgt tttcctaaaa atcaaattgc ccatggtgtc 3503101 cgctttccac gctttgacga tcgccacatc gccggtaatg cctcgctcca gcacataagt 3503161 ccggccgccg aatgttttat gttcttttcc ctcggctatg gaggtgccga cgcctgtcgc 3503221 cgtataaaat cccggtatgc ctgcaccgcc tgcacgaatt ctctcagcga gcgttccttg 3503281 gggaacaagc tctacctcaa gctctccgct taaaaactgc cgctcaaaaa ttttattttc 3503341 accgacatag gaagcgatca ttttcttgat ttgcttgtta gccagaagca aaccaagccc 3503401 ccagtcatcg actccgcagt tattgctgac aacggttaaa tcctttactc cctgatctct 3503461 tatagacaaa atgagctgtt cagggatgcc gcacagccca aaccctcccg cgatcagcgt 3503521 atccccatca tgaatcagtt tcgcagcttc cttgcttgat gacagcactt ttcccatatt 3503581 gatgcccctt tcgttttctt ctacactaga ccagtcaggc tgtaaatcgc gatcacagca 3503641 aatacggcag ccgttttaat gagcgtgatc gcaaaaatat cgcgatagga ttgccggtgg 3503701 gtcaaacccg tcacggccag aagcgtgata acggcgccat tatgcggcag tgtatccatc 3503761 ccgcctgatg ccattgaaat gacccgatgc atcacctctg gcggaatatt gtaagcctga 3503821 atcgcctgta agtattgttc tgacatcgcg cttaacgcaa tgcccattcc tcccgaagcc 3503881 gagccggtga ttcccgccag cgcagttgtc gtaacggcgc catttacaag cggatcggta 3503941 aaagtatgtg aaattccgct gctcagctta tgaaaccccg gcagcgcggc gataatgccg 3504001 ccgaacccgt actcagcacc cgtattcata gatgccagca aggcgccgcc aattccttca 3504061 ttcagccctt ccttcaattg ggcaaacaca cttctccaat caaataatat cgttgtgatg 3504121 atgccaatca ctaaagcaat ctccaccgac caaatagcag ccgctgaaga aatatcaagc 3504181 ctgccgaact cctttaatcc tatggaagaa aaatcaaatc cattcggata ccactttggc 3504241 aggtaaatgg tgaaatattt attcactgca ccgacgagaa taagcgggac aaaggcaagc 3504301 gcgtgccgaa tcgggctttt gtccggttca gccgcggact caatcgattc aggagcagga 3504361 gcattctgcg aatcaaaacc gccatagcct tcgccagatg cctgcgcttt cttccgcctt 3504421 gattccaaat agagcatccc agctgccagc acaatcactg cgcccatcaa acccagccaa 3504481 ggggcggcat aaatgtctgt tttgaaaaac gacgtcggga tgacattttg gatttgcggc 3504541 gttcccggaa gtgcgtccat cgtaaacgta aaagctccta aagcaatcgt acccgggatg 3504601 aggcgttttg gtatgtttgc ttcttggaac atgtttttcg caaaaggata tacagcaaat 3504661 acgacaacaa acaggctgac accgctgtac gtcaagacag cacccatcag cacaatggca 3504721 agtatcgctc tttttgcccc gacaagccgg acaattgttt tcgcgattga tgccgcaagc 3504781 ccggccattt caacgacctt tccaaaaata gcaccgagca aaaacactgg gaaatacagc 3504841 ttaataaaac ccgccatctt ctccataaaa attgatgaaa aaaaaggaag cacatggctt 3504901 ggatctgtca gcagcaccgc gaataacgcg caaatcggcg caaacaatat gacagaaaat 3504961 ccccgatacg ccgtaaacat cagcaaacct aacgccaata gaatgatgat cagttccaca 3505021 cacacatccc ccgtttccgc gaactagaaa gcgtttacaa aaacctgtcc gcatcggctg 3505081 tttccgtccc ctttccatat gtacgagaag cgtgggccaa ctattccgat taaaaaagga 3505141 aagctccttt tttcggagct ttcctctacc attcatttca ttcctattag gatatcaaca 3505201 tcaaccgtaa tatcggctga tttcatctct ttcagcaggc tgactcgatc tttcggcgcc 3505261 gaccaggcaa gcggcgtcat cttgagaagc cagtggatcg cctgctggtc aagcgtttta 3505321 acatagcgca gcctgacagg acggctgtgt gctgcatttg ctgtaaaacg ctcaactgct 3505381 gccgtattgg aatacgtgcg ccttggtgaa tcagtatata aaaattgcct taattctatt 3505441 aaatagtcgc ttcgcggcac tacttttatg agcatgccat cattcttcag cagtctatga 3505501 aactctgcat aattggacgg cgaaaaaata gacagaacaa catcaaattg gcgatcatga 3505561 aaaggagcac gcgccacatc ggcaaccgcc cacatcagat ctttgaatgc cttagaagct 3505621 tttaagatcc cgtccttcga aagatctatg ccggttccta tcgctgcttt ccctgcataa 3505681 tcaaacccgc aaagcgcatt caaatgagaa ccctcaccgc aaccgctgtc caagatggtg 3505741 aatgcctcat gaccagattt gggatgactg atgagctctg caatcgcatc atggagcggg 3505801 tcaaaaaaac cacattctcc aatcagcctg ctcctcgctt caaaaagctc ggcaccgtaa 3505861 ctggttttga ccggcttcgt cagaaagttc acgtagccgt gccgagatag atcaaatgta 3505921 tgtcctcgtt ctgtacaaat caagcttttc cctgatgccg catccataga agaatcgcag 3505981 agcgggcatc gaaacatgct gaaatcaact gttcgcttca tgataaaaaa caccccattc 3506041 attcattttt agataaatga aaaaggcata gacaaataaa cctaggccta tctcaaaaat 3506101 tggccaggtc tggcagtttg tctacacctg tcattatcta taacgaatga attggataat 3506161 catgaaaaaa actccctttc tgctgtatgg gtttccccgt ttccatcata caacaaatat 3506221 ccaggagctg gaaccttata gtgaagaaaa atcagtactg acatgctggt atcccgccaa 3506281 catcatatca gcatagcaat ccagcatgtt tttcctttat tttctcattt tagaatataa 3506341 attttattat tgtgaaaata gttaaaaagg ttgattttca aaaagtgaaa ggataaaata 3506401 ctgctatcat cttagaaaaa gacattcttg tatatgatca gtaatatggt ctgattgttt 3506461 ctacctagta accgtaaaaa actagactac aagaaagttt gaataaattt gaacgagttg 3506521 aaaaggacaa gttcttttct gtttgctctt atttttcaca ctttctgcac ttccagaatt 3506581 tgtgaaggat aagagctttt tttgtttcca taataaccct cataggagtt gctatcatgt 3506641 actttttact aaaccttgtc ggtctcattg tgattatggc agttgtattc ctatgttctc 3506701 cgcagaaaaa gaaaatcaag tggcgcccga tcattacgtt aattgttctg gaattgctga 3506761 ttacttggtt tatgctggga acaaaagtcg gaagctgggc catcggtaaa atcggtgatt 3506821 tcttcacttg gctgattgct tgcgccagtg acggtatcgc gtttgccttt ccgtcagtga 3506881 tggcgaatga aacagtagac tttttcttta gtgcgcttct tccaattatc tttatcgtca 3506941 cattctttga tattttaacg tatttcggca ttttgccttg gctgattgat aaaatcggat 3507001 gggtgatttc aaaggcttcc cgcttgccga aattagaaag ctttttctct attcaaatga 3507061 tgttccttgg aaataccgaa gcacttgcgg tcatccgcca gcagcttacg gttttaagca 3507121 acaaccgcct gctcacattc ggtttaatga gcatgagcag catcagcggc tccattatcg 3507181 gatcttatct ttcaatggtg cctgcgacat acgtgtttac agccattcct ttgaactgct 3507241 taaacgcgct gattatcgca aacctgctga atcctgttca cgtgccggag gatgaagata 3507301 tcatctatac accgcctaaa gaagagaaga aagacttttt ctctacgatt tctaacagta 3507361 tgcttgtcgg catgaacatg gttatcgtta ttttggcaat ggtgatcgga tatgtcgcat 3507421 taacgtcagc agttaatggc attcttggcg ttttcgtaca tggcctgacc atccagacaa 3507481 tttttgctta tctgttcagt ccgttcgcat tcctgcttgg actgccagtg cacgatgcga 3507541 tgtatgttgc tcagctgatg ggcatgaaat tagcaacgaa cgagtttgtt gcgatgcttg 3507601 acttgaaaaa caatctcaaa tcccttccgc ctcacaccgt tgcggtggcg acgacattcc 3507661 tgacgtcctt tgcaaacttc agtactgtcg gcatgattta cggcacgtac aattcgatcc 3507721 ttgacggaga aaagtcaacg gtcatcggga gaaacgtgtg gaaactgctc gtcagcggaa 3507781 ttgcggtatc tttattaagt gctgcgattg tcggcctgtt tgtgtggtag aaacattgag 3507841 ccatatccct tttcggatat ggctcttttc attattgata aatagaggct ggcacctgca 3507901 catcccggat tcccgctgca taaggcccca agtcatactg gccgaagacg atggcgatcc 3507961 cgtttgccgt aaagtaaaac attgtgtctc tgtttagggt tatatcctct ttctttacat 3508021 cagagaaaaa cagcacatcg tgttttttga tatagctata taggtaatct ctcgttttgc 3508081 tgacttttgt tttggtgttc agaatctgat ccagcgtcac ccgcttttgt gctttcaagt 3508141 catagttgaa ggactggaca gacgttagac cgtgggcgcc ccctgaatag atataattga 3508201 gtgtttgaat gctgagcttg cctgccgcat tgtatttgac gctgaaggat gtttgatatt 3508261 cccgttttaa agccctgctg ttcgcctgct tttttgtttt tcaggtattc ctgatacgat 3508321 tgttcatgta ggctttcagc tcttgattga ttttcttttc aaacgcggca ttcccgacgt 3508381 gatgcacttg tggatacgtt aactccttga tctttttgta cgtatgggtg ctgacagtcg 3508441 gtgttttcgc ttgaactgct tttaaagatg gggccgcata tgcaaataca gaaaaaagca 3508501 agactgcaat gcccgcggct ttcagcatgt tattccattt catacaatct actcctttga 3508561 tgtcgttgtt tatcattccc ttatttaagc aatacacact tttatagact gattaaatcg 3508621 aaagaagttt ctaggtctaa cagcatgatt tttccaataa aaaaagagac acaggatgtc 3508681 tcttttttta ctgtttgcgc ccagaaatcg cttcatgaag ggcttgtgcc aaatctgtat 3508741 ttccgaacat ctctaatacc gcaatgacag tctggtccgg aatgtgctct gcttcgtgtt 3508801 ttggcacgac cagatcgtcc atggtttttt tcaagctttc attcagcttt tgctgcggat 3508861 acgctttggc gtacagctcc atcggatcaa gatcatggtt cacgcaccac tgggcaaaca 3508921 ccaaaatcat catattttca tcgcgttcgt aagcttcagt gagctgtttt tcgttcattt 3508981 gtcatgctcc ttatgaaaag tatcttcctt aaagatacag gagccgatca aattcgtcta 3509041 tcccaatggc gatgagcagc aaccgcatcg ataaatgcct tgctgaaagc ggtgtagtca 3509101 ggttcatctt tagccgttac gatgcctagc ccctctgttg tcccgacaga ggattgaaga 3509161 aggtcaattc cttcatttgc cgcaccgatc gccttgtagt gattgtaagc ttctctgata 3509221 aacgccatcg cttgtttgtt gtcttttaac tccagtcctc ctgcggcata gacggcatca 3509281 tacagaacag aatcaaccgt caggaacgtg ccgctggcct caagctgctg tccgctgccg 3509341 cttgtcatat accccagatt ttgactgatg atatccactg tgattccttc ttgctttaag 3509401 gcttccagta ctgtttgcag ctctttttca tgaaatccgt ttccggcgag tacagcgact 3509461 tttcttgttg acgcggtttt cactgtacgg gcttggctta acgcaggcga agtaagaatt 3509521 tctttagatg ctttacgctt cgcgggcgcc gccacgccta ctcctttggc gatttcttct 3509581 gctaaatctg catcgacatt gctgaagaca tcaacgacct gccgctgtac gtctttgctt 3509641 ttgaccttcc cgacctcgaa gcagaaagca gaaatgatgt gctgtttctc cacaggagac 3509701 atgctgttcc agaaaagctt cgcctgtgag taataatcgt tgaagctgtc gcttcgctgg 3509761 cggatttttt tgccctcgac tttttcctga tagtggacgt agccgccttc ttcagctgtc 3509821 gcaggcgacg gatcattgtt ttgcagtgag tttttatgat aagcgacagg tcccttattg 3509881 atcgtcatcc ggtgatagcc gtcgtattgg ttgttatgga atggacagac cggccggtta 3509941 atcggaatct catggaagtt cgggccgcca agacggatga gctgtgtatc cgtataagag 3510001 aaaagccgcc cctgcaatag cgggtcattg gtaaaatcga tgcccggcac gacatttccc 3510061 gggtggaatg cgacttgttc tgtttccgca aacacattat cctgattgcg gttcagcgtc 3510121 atttttccaa tgatcttcac cggcacaagc tcttccggcc acagcttagt tgggtcaaga 3510181 atatcaaaat caaacttgaa ttcatcttcc tcatcaatca tctgcacgcc gagctcgtat 3510241 tcaaccttgc cgccgttttc aattgtttcc cacaggtcac ggcggtggaa atctggatct 3510301 ttcccggcaa ttttttgcgc ttcatcccat acgagagaat gcacgccgag caccggcttc 3510361 cagtgaaatt tcacgaaacg tgcctttcct tgttcattga caaaacggaa cgtgtgaacg 3510421 ccgaagcctt ccatcattct gtagctgcgc gggatgcctc tgtcagacat cgtccacatc 3510481 accatgtggg cagactcagg gttattggcg acaaaatccc aaaatgtatc gtgagcagtc 3510541 gcagcctgag gcatttcatt gtgtggctca ggcttaaacg cgtgaaccaa atccggaaat 3510601 ttgattgcgt cctgaatgaa aaacaccgga atgttatttc ccacaaggtc atagtttcct 3510661 tcttcagtat aaaattttgt cgcaaagcct ctggcatccc gcaccgtgtc tgcggagcct 3510721 ttagaacccg caaccgtaga aaaacggaca aataccggtg tcttcaccga agggtcctga 3510781 agaaatttgg cccgtgtgta ttccgtcatt ggttcgtaaa cctgaaaaaa gccatgcacg 3510841 ccaaatccgc gcgcatgcac aacgcgctcc ggaatcctct catggtcaaa gtgcgtcatt 3510901 ttctcccgga aatgaaaatc ctccatcagc gtcgggccgc gaaccccggc ttttaacgag 3510961 tgctcatcct ctgacactcg caagccttgg tttgtcgtca ttttcttccc gctgttatcg 3511021 gtcctgtact gctcaagctg ctcgtccttt gagtgttcat ttacacgttt gttttggtca 3511081 tcactcatgt ctgctccccc tttttaaaac gaaacattct acagcacatt tacccgtggc 3511141 gttcttcata taaactgcta atccgctcat taggattttt ggtctacata taaatatgcg 3511201 gtcatacaca tttgaaataa gccttcttca cagaaagaaa ggatggaagc gcttaccaaa 3511261 aaagctgttg aataggggag gtcatatcat gcttgccata ctcggttttg tgatgatgat 3511321 tgtctttatg taccttatta tgtctaaccg gctttccgct cttattgctt tgattgtcgt 3511381 tcctattgtg tttgccctga tcagcggatt tggcaaagat ctcggcgaga tgatgattca 3511441 gggcgttaca gacctcgccc ctaccggtat catgctgtta ttcgccatcc tgtatttcgg 3511501 cattatgatt gactcaggcc tgtttgatcc tctcattgcc aaaatcttat cgtttgtcaa 3511561 aggagatccg ttaaaaatcg ccgtaggcac agcggttctg accatgacca tttcgctgga 3511621 cggagatggg acaacaacct atatgattac cattgcagcg atgctgcctc tctacaaacg 3511681 gctcggcatg aaccgtttgg tgttagcggg aatagcgatg cttggttcgg gggttatgaa 3511741 tattatcccg tggggcgggc cgactgcgag ggttttggct tccttaaaat tggacacgtc 3511801 agaggtcttt acaccgctga ttcccgctat gatcgccggc attctctggg tgatcgccgt 3511861 tgcttatatc ctcggaaaga aagagcggaa gcggctcggc gtcatttcga ttgatcacgc 3511921 accgtcttcc gacccggagg ccgcaccgct caagcgtccc gctcttcaat ggtttaacct 3511981 gctgctgact gtcgctctga tggccgcact gatcaccagc ctgctgccgc tccctgttct 3512041 ttttatgact gcgttcgccg ttgccttgat ggttaactat ccaaatgtca aagagcagca 3512101 gaaacgaatc tcggcgcatg cgggtaatgc gttaaacgtt gtctcaatgg tgtttgctgc 3512161 gggcatattc acaggcattc tctccggcac aaaaatggtg gatgccatgg cgcattctct 3512221 cgtttcactc atccctgatg ccatgggccc gcacctgccg ttgatcactg cgatcgtcag 3512281 catgcccttc acctttttca tgtcgaatga cgccttttac ttcggtgtcc ttcccatcat 3512341 cgccgaagcc gcttccgctt acggaataga cgccgctgaa atcgggaggg cctccttgct 3512401 ggggcagcct gtgcatctgc tcagcccgct tgtgccttcc acctatctat tggtaggaat 3512461 ggcaggcgtc agctttggcg accatcaaaa attcactatt aaatgggccg tgggaacaac 3512521 gattgtgatg accattgcgg cgcttttgat tgggattatt tctttctaaa tgtatgagct 3512581 tgatcgtagc attgagtgag tacgtgattt acagagggga gaagatcaaa taggatatta 3512641 tgagtgaata gaagattcat gccaacaact tctcattaca atcataagag cctgctatat 3512701 tgcagcaggc tctttcacat ttggcattat ttttttgtat agcgcaccca gtcataatga 3512761 gcgtatagcg gatttacacc attgtaggag ccaagccatt catcgacacc cgtgccattc 3512821 cacaagttca tcatgatctt tccaggtgtt gtcggaattt ggtttgttgc agtatgtttt 3512881 aattgcccgt cgacatacca tttaatagag tttggctgcc aatcgaatgc atacgtatga 3512941 taggcattgg ctgcatcaaa cccgagatca acaatcttct catggtttcc tgcaccattt 3513001 gtataatagt taaattgaac cttcgttgtg tcttttccta aaaattcgat atcaatctca 3513061 tcccaaggag ttccatctgt tggacctgtg taagtgaaga acgatgaaac gatccctgtg 3513121 tttttagctg gtttcattct gacttcataa agtccatagc catatgtttg aacagaacgg 3513181 ttttccccgc agtcaaactt gttataagct gggcttgtta gcgctaaacg catttcaccc 3513241 aatgacgtca ttgatacgtt attagcccgc cacgtgcagt tgaacatatt tccattcgaa 3513301 taaccatctg ctttttgcca aaaaccggag ttatagccgt taaaagggtc aaaaaacgat 3513361 ccacctgttt gagctgaggc agtagcagtg actgcaaaca aactcataaa caatccagtg 3513421 acaagaagca gcaacactcg tttcagataa ggcatattgg cattcccctt tcattgaaag 3513481 cgttttctat gttgatctta catgattctt ttaaaaggga acatcggtca aaataatgat 3513541 aatatcgaat cttactaact tgaatcctgt aactatcatc atcttccctc tgaaaaaaat 3513601 aaaaacctaa attaccatca gcacagacag agatgatccg cactcattgc aatttaggtt 3513661 ttgcctgctt tatcagtaac aatcctacca ttttcatatg tgaatgtaag aaaaagtgaa 3513721 cacaaggaaa cacaaatgtc agcgctctca ttatgcttgt ttaactaccc tttctatgtg 3513781 aatggttaaa tacagcagct cgtcacttgt gagcttgtgc tcatactccc gctcaatgta 3513841 ggtttggatt ttcttcgtgc attcatacgc gcgatgatac ttttctttca ctgtatccag 3513901 caaaaaatcg tcctggcttt ccatgtgagt gccgttaaat agacgctgcg cgaaaaactt 3513961 taagtgggtg acgaaccgat aatagtgaag cgattcttcg ttgaattcaa tcttaaaatg 3514021 gtattttaca atactcaaaa tctcttgcat gacttttgta atgttgataa tattgggcat 3514081 ctcttcattc agctcggcat ttacaatatg cagagcaata aagcctgctt catcctctgg 3514141 cagagacaca ccagtcttgt tttttaccat aaccaacgct tctttgccga tcgcaaattc 3514201 gtctttgtag agccgttttg tttcccacag caaggcgttt ttgatatcaa gccctttctg 3514261 gttgcgctgg atggcaaagt taatatggtc ggtcagcgac acatagatgc tgtcgttgag 3514321 ctttttgccg agctgtaatt ttgcgtagct gataatctct tcggatactt ccatacactc 3514381 gatcggtata tcatacaaaa gggttttgaa cttttctgat acatccttgt tatcgagcgt 3514441 gaacactttc tcaatgcggg cttcatcgac atcatcgccg gactttttct gaaacgcgag 3514501 ccccctgccc atgacgacca attctttccc ctgttcattg accacgctga tcacattatt 3514561 gttgatcacc ttcgcaattt tcatggcatg tccctccaaa tctactaaga acagactata 3514621 tcttgattgt acattctttt tgtactaggt caatatcatc agggaaagac ggaagctggt 3514681 cagtacaatt cactccgtac ctgctgcccg ggctgttttt gaagcagcgc ctccagatgg 3514741 cgttcaaatg atgccttgtc agctttctgc tttttgacaa tgctgttcat gattttaatg 3514801 ctttcagcac tgtattgtgt atattgtttt ttcagctgat ccagctgctg tcttgtcttc 3514861 ttcgcgtttt tcggtgtgac ttggttgatg agtttgatca tactgtctgc ggtctcaaaa 3514921 aaaccggctc tattttctgt cagctgctga atttcgatgc ggctcatatc ttgattacgc 3514981 gttttttgaa gcaaggcaac cgcctcgctg ttttgttttt tgagcgattt gttctcaagc 3515041 ttaatcgatt cgagattctc cttcgcaatg tctgcttctt cttcagtcat gctgattcgc 3515101 acgaagtatt ctggattgcc gattccataa tcaaatgctt cgctcacttg tatcatggaa 3515161 ctgaacacaa tggccagctg cctgtcgctt gcgagggctt ggaaatcctg ctttttctta 3515221 ctgctcatcg gtttggctgc ggtttgtttt actgtctttt gatcacagtc tgcgaacatc 3515281 tgagcctcac cttcactttc gcatgcgctc atcacaagaa ctgtgaccag caggcttata 3515341 cacaagccta ttcgcctcat gctctgtctc ctctctgctg aatcccttct ggaaaatacc 3515401 ataaaatata gttaaatggt accagatgca cctaacccca gcaataaatc aaaagtatga 3515461 tttgaagcga aaaaacataa atattttgta aaaattgacg tgcattccat tcttttcagg 3515521 cccatttctc gtacaataga agtatcgtta ccggagaggg gctctgatga tgaaacgttt 3515581 tacgaaacaa gaaaacagct gggtgttata tgactgggca aattcagctt actcaattgt 3515641 cgtgaccacc gcggtatttc cgttatttta taaatcagca gctgcggaaa gcggtgtcag 3515701 cgccgctcaa tcgactgcct atctgggcta taccattgcg atttcaacgt ttattcttgc 3515761 gatgctcggc cctattttag gcacaatcgc cgactatgaa gggtgcaaga aaaagttctt 3515821 cggtttcttt gtgtcagccg gtgtcgccag caccgcgatg ctcgccttta tccctagtga 3515881 acattggctg ctattgttgc tgttttatac ggtatcggct atcggttttt ccggcgccaa 3515941 tgtgttttat gatgcctttc tcgtggacgt cacgcctgag aagcggatga atctcgtctc 3516001 ggcacggggt tttggcttag gatacattgg aagcacgatt ccatttatca tcagtattgc 3516061 tgtcatcctg ctcgcacaag cagagactat tccagtgtct gtatcggccg caagccagct 3516121 gtccttcttc ataacggctg cctggtgggg gctgttcacc atcccaatga ttaaacatgt 3516181 ccatcaacgc tattacatca aaaaagaacc tcatattgtc atcaacagct ttaagcggct 3516241 cggccaaacg atgaaacgga tcaggcaata ccgggcactt ttcctcttct tgctcgctta 3516301 tttcttttat atcgacggag tcggcacgat tattacgatg tcgacatcct atggatcaga 3516361 tttagggatc ggctcctcaa gccttctgat catcctattt gtcacccagg tagtcgccgc 3516421 gccgttttcg attatatacg gaaaactggc agaacgcttc acggggaaga ccatgctgta 3516481 cgtcgggatc gtcatttata tgatcgtctg cgtgtatgcc tattttatgg agacaacgct 3516541 tgatttctgg atactggcta tgcttgtcgc cacctcgcaa ggcggtattc aagccctaag 3516601 ccgttcctat ttcgccaagc ttgtgccaaa gcgccacgcc aatgaattct ttggcttcta 3516661 caacattttt ggaaaattcg cctcaattat ggggccgctg ctcattgccg ttaccgccca 3516721 gctgaccggt aaatcctcga ctgcggtgtt cagcctgatc attttgtttg tgattggtat 3516781 tgtgattctt gcctttgttc ccgaggaaac cagcacagat gtcagccagc agcaaaatga 3516841 cctgcccctt taactgggag caggtcattc atcatttatt cgctttattc accttcagct 3516901 gtttcccttt gacggttgtg ttcttcatca ctttgagaac atgagggcct ttaccattta 3516961 aaatctcaac gtatgaggcg ttatccatga tcgtgatgat gccgatgtcg tcagctgaca 3517021 caccgtcaat tttggcaatc gttcctacaa aatcaacggc tctgattttc tttttctttc 3517081 cgccgttaaa atacagcttc ataatgtctt tattcagctc ttcgcttttg tcctttttgc 3517141 tttccggacg gtcattcagt ttagctagaa attctggttt cttccttgcc acttcctctt 3517201 gagaaggtgc ttctattttt tggatttcaa atccgatata ttcttcaatg tcggctaaaa 3517261 accgtttttc gaaggccgtg acaaacgaaa tggcctttcc tttgttccct gcgcgtcccg 3517321 ttcggcccgt gcggtggaca tagctttctt tttcaagcgg cagatcatag ttgatgacaa 3517381 gggagatatt ttcaatatca atcccgcgcg cggcgacatc cgtcgccact aagtaacggt 3517441 actcgccacg tttaaattca ttcatgacgt cgaatcggtc ttcctgaatc attccgccgt 3517501 gaattttatc gcatggatat cccaagtcat ccaattcatc ggtcagctga ttgacgtgct 3517561 ccttcgttcg gcagaaaatg atgcagctgt cgggattctc cgtcatcagc acatctttca 3517621 gcaatgaaaa cttattctct tctcttactt gaatcaccgc atgttcaata tttcttgtgg 3517681 ttaggccggc cgctttgacc tcgatatgct cggggttttg catatattga cggctcagct 3517741 tctcgatatc ctgcggaagc gtcgctgaaa acagcatcgt cgtacgctca gtcggcagat 3517801 gcttgataat cgcctccacc tgctcaatga agcccatatt cagcatctca tccgcttcat 3517861 caatgaccaa ataagagaga cgatccaacg gcagcgtgcc tttttcgata tgatccagaa 3517921 cacgtcccgg cgtgccgaca acaatgtggc ttttttgctt aagctcagct ttttgtttat 3517981 caaaggagga ttttccaaat acggctgtcg ctttgatccg tttaaatcgt ccgatgttcg 3518041 tgatatcttc ctttacttgc accgcaagct cacgggtcgg tgttaaaata agcgcctgcg 3518101 gcttgttttc atcccaattc gccagctcac agagaggaat cccgaacgaa gccgttttcc 3518161 cgcttcctgt ctgtgatttg acgacaagat cctttcgttc aagggcagcg gggatcacac 3518221 tctgctgcac cttggtcggt tctgtatatc ccagtccttc caatgctcgt aaaatgtcat 3518281 gactgatttg atagttttta aaatgactca tgtataaact cctgtctctt gcagatgttc 3518341 tcattatact ctaattgacc aaggcatatg tgttttgtcg aaaaatgatg tattaaaagc 3518401 cagcgattcc ctggcgtttt agctcctgaa cagccaatcg cgccagtgcg tcggcccccg 3518461 cgcgattcgg gtgcagcgta tctccatcca tataaagccc gagtgttctt tccggaccga 3518521 tcgatgtaaa gtatgccgag ctgaggacat ttaagtcaat gagatatgtt ttttcctctt 3518581 cggccaaagc taaaatagag gccctgtacc atctgtttac agacgaatgg atgccttcag 3518641 aagtaaaatc ggttgcccgg ccctgaggcg ttgataggat gacgtccgct cctttcgctt 3518701 ttacctgacg aatcatatca cgcatcacct ctttaaactc cgcttcagat tctttatgct 3518761 tcggatttgt gtcattaatg ccaagctgca acataaaata atctccgggt ttaatatact 3518821 tcagaatcgc ctcaagctgt ccatcatttc tgaaccctct cgcgatctgc ccgccagacg 3518881 ccatgtttct cacttgaaag gtgtgtttat cgatatagtg aggcagcatc tgcccccagc 3518941 ccgcctgctt gctgctgttg agcggataat aattgcacac cgtcgagtcg ccgccgacat 3519001 aaatggttcg attcgttacc ggctgatcag acaatttctt tattttcaag gcgctgagcg 3519061 taaaagcggt gcctgccttt ccctctgtca ccagcagatt cagctgcccg tcggtgacgg 3519121 gaatttggaa cgtatcctcc gcgccatccc ctgtcatatt gatgacctga aacacgccct 3519181 ccgctgccac actggccctt gccgtattgc caagcgtcac cttcacctca taaaggccat 3519241 tcgggagatc aacattaaac gtgttattgc ttttcgtccc atacgctaaa aactgaaccg 3519301 catcactctt cacaccagcc ccggatgccg ccacatccct catattctcc ggtgtttgaa 3519361 aaccgtagcc ctttgaccgg tcataccgat cagacgccct gacaccaata taaccaggct 3519421 ccatcgaacc gcttccaaag tcaaactgat acaccttcgg ctccgccgcc ttcacattct 3519481 caatcccgcc aaaacacagc atcagcatca tcacaaaaac cgctgccatc cattttttca 3519541 tcaagactcc ccctctatga aaacgaatac attaatgcat actcggtgat tgtttcttta 3519601 tgatgactga attaagaaaa aaattgcgtt gaggaataaa aatgagggga gagtctcaag 3519661 aaggggaaaa tcagtgtgac ttcttgtcac acttgatcac atcccaacct ccgcaataga 3519721 agcttatttg gttttcttcg tcatacacat aataacggag tctttcccat tgatcgtcag 3519781 tcggtacaat ctccaatgca accgaatcga tggattcaag gtcatccagc tttgatgcac 3519841 taatgttttc aaaccgcaat tgaatgtcac aggtttgagc agatcgtttt cattcaaaca 3519901 caggaatatg aatataacga tcatcttctt tcatatagaa agaaaactcg tttaatgtaa 3519961 atggacctgt atcctcatca gaaagatgct gtttcaattt ctcgtattgt gtgatattca 3520021 aatgaattcc ctctatttat atgattcacc gccaatcata taaatgtcca cagcatcgta 3520081 ttcaaaccat atgatccgtt cgcctgagtc cgttaggcat tggagcttcc cttctgaaaa 3520141 atagctttta tccggttgag gatcagtgat cagaaaaaca tcatcattga tggaagctag 3520201 cagaaagaga aaatctgcaa tatcccggtc tgcttcctgt aatatggatt ggaaatggaa 3520261 ttcccttttg gccagcttcg tcaccttgta agcatgacct tcaaaatact cggacaggtc 3520321 ttctataaat gaaccagtcg ttattacctg tatcatgatt cgatcgtagg caagccctgc 3520381 ccaaaaacga taaaacgact ctgcatcttc aagttcgcat gccataacgg tttggtcagg 3520441 cttaagctcg atcatgtcca aattgccaat actgcttata gaggttattt ccataaaatc 3520501 ttccccttat cagttggata gcgcaacgca aatctcttgt ctgacttgtt catacaagag 3520561 aatgtgatga tacagatcct tatcgttttt gatcatatcc ggaagtatgt caggatacag 3520621 ctcaaaaaag cttttctcca acgaacgccg ctgatgccgg ggtatccttt tattcgccag 3520681 cacataatcc aaactgccag caacaagcat aaaaaactca tagatttccg cttcaaagcc 3520741 gtacaattca tcagggtact gcttttcttc aagctctcgc tgtctttttc tcagtttttg 3520801 aagcacgttg atcctctccc ttccgcaata atctcattta tttcgaaaca gaataggcgg 3520861 atcattatct atcgcctcca acagctcttc accaaacaca gtgattgcac atttccacgg 3520921 gtctcccaaa agtccccagg agaagtcctg atgaaaaaag aaataatagt ctccatttgg 3520981 aaatacggga acaggccatt cgccaaattc atccttaggc attgcctgat gaggactaaa 3521041 ggtatatccg tcatgctgcc aatctagtgc gtacattaca tcgttctttc cagtacctaa 3521101 ttgaaatgct tttaaaatag aagtctctaa atcacttagc actccgctca catcattatg 3521161 accagcttta ctgctcatcg cgcttgagat atcaaacact cgatatggat caggcgggat 3521221 gatgtgatga catctgcttc cgggcttcca ttttatgatc ttgttcactt ctgaccagat 3521281 gcggtcttgt tttgtctgac ttaaagcgcg ccaattcatc ataatctcat ccctacacct 3521341 tattggatat cctgcttata aacaccagaa gaggccactg cgtaaacagc gtaacttgtc 3521401 agtttcagct gttgaacatc taggccttca ccgttcgaat cacagcatgt tatctcttcc 3521461 atctcttgac tcacatcggc agaaatcaaa taaagagacg acttaaggtc tgcactgtaa 3521521 caattgaacg tcccaaccaa aaaaccttct tcggatatcg cgagctgatc aaatgcttct 3521581 gagtccggct ctttatccga cagaatccac acccgtctca cgaccgtttc atcaaatgcg 3521641 gcaatgactg catctccgta atacagcata taaatcaagc cgtttttttc tgcaagtcca 3521701 taacaatcat ctacagcagg cgcatccatt tcttcaagct ttctatcaat gtgtatttcc 3521761 ttctgctgac catctaacgt aaaacaccac acactatggc cgttgggatt ctcatcatga 3521821 taaatccctt catcacataa accgacccaa agctgttgtt tctaatccaa aagacagcag 3521881 gaaacccctg aaggcaagtg aaaaacactt ttcacccttc cctcttctga aaaaaccttt 3521941 accttcggct cgtacgattc gtaataaacg aagacatagc catctgcaca ttgttgaaag 3522001 agcagaatat cactgtatga aatctgctct ttcactctaa aatcccgaac atcaccggaa 3522061 ggatcataga ttgtaatggt gataccacct ttcaaccctt ttccaatgta gacacgcccc 3522121 tgtggatcag catggaaaaa acaatcttgg gtgttctcgt tgatgatttt attcaatttt 3522181 aattttttca ttggttatgc tcctaggttc gaaatgaaat gataagaata aaccatttat 3522241 tagctattag taacggacaa cctagtttca ttaatcgttt tgggataaat ctactttcca 3522301 attcagcctt aaatcattta gtgtttaatt ggtatgcata aaacgattga tcatcaaagc 3522361 gaactgtttc agcttctata gcaatcagca ttctgttcat gtcaataaga aagttagcat 3522421 ttgattgata ctccggaatt atagaatttg atagattccc gattccttct ggatgataac 3522481 tcatctcaaa tacttgccaa ttgtattctt ccggatctat tttttccaat ctcatgtcgc 3522541 caacatctgc actataataa gcggatgcca cattttgaaa tgaaatttta tgcgtatatt 3522601 caccttcatc ttcaaaaacc ttaatatcaa gtgagagttc ttttttaaac acattaaaat 3522661 ctaaatgaag gacactgcac cccttatcta tataatcaac ccattcatta atcgtttgat 3522721 acattgtcat cccctgcctc tttttaaaca ataacgcctt gccaccaagc agaaaacaaa 3522781 ttactccgta tattgtttga tccaatcatt taaatcatct gttgaatgca aataagtttc 3522841 tgatgaatct ttcaaatcaa tcccacttag aaggattaac atatcccaga ctctatcgtc 3522901 ttctacttcg gggtcatccg cataaacata agttccagcc caatccgaca cttcttctct 3522961 tgttgtttgt ccatttaaga cacttttgat tttatttatg cattctatta gatttgtctc 3523021 gctcaatttg atcaccacgt attcaagtac taaatgattt tttattagta tgcaaagcac 3523081 cgtactgata tttagatatt gaagcttttt ccgtaaaaga tatgttccaa aaggtttcca 3523141 atctaccaat aaacaagctc acatccgtat tccgtgtgca atatacataa accaaactgg 3523201 cacttaggct caaccaaaat aaaactatga ttgagaatcc cttcatcgaa ctcaatacac 3523261 tccaataagc agtcaaggtg ctcgagacat tttccaaaag aacaaactaa cgcaccaatt 3523321 tcgctgctgt attgatgaaa cagcagaacg tcccggtcat cgtaagcaac atatgactga 3523381 gatattttcc agatcagctg tttcgcttcc gttttttcga gggcatcaac ctcacgggtg 3523441 ttggctggta ttgaatttga taaaaccagc tcaagcaatt gcctgctttg cgccagatca 3523501 gcaaaacgat aagtgaagcc tctttctgca caagggacta gtttttcttt gatttcgctc 3523561 atcaataaac gtcttttatt ctcggcgagt ttttcgatca atcttttttg catgagccgc 3523621 attccctccg ctgtcaattt ctcaacttct tttaaattga ttcatcattc tcttgttttc 3523681 gttgtcgttc atgtttagat ttgttctaaa aaagcttgta tcgcttatcg atacaagctt 3523741 tatcttcaac tgcttaaaac tcacccagtg ggcttttcac aaaacgctgg gaaccttttt 3523801 ggcaaatcct cttcatccca atcaattcta tatttttaga ttcttttgtc atacaaataa 3523861 gagaggatgg taacatctct tatttaatgt tccatcaata aatgccccat ttttatccaa 3523921 tgcagaaatt atttataatt aaggaagttt agaaggattt tttgtatttt caagatttaa 3523981 ttttaaagcg gtcacaaaag actctagctt ttcttcatta caattaattt cgaacaagtt 3524041 ggagttcgac ttactttctt tataatcatc aaatataatt ttaatcttaa ttctgtaatt 3524101 tccgttttct tgatcaatac taagaaataa gaatggttca atagtctcta aactgatact 3524161 gtcttgattt ccttttatca tagtttcgat cccagatatc aacaccttat attcactttc 3524221 taataaaaca gcagaaaaat cgcgaacgac ggctttctta ttttccaaca attcaaatac 3524281 agataaaata aatggatcat cgtccaactc ttgatacctt ctcggtgtta attcaagttc 3524341 tatacaatca tcttttattt tggccatatt tcctcctcat ttaaagttta agtgagggta 3524401 gttgtcatcc ccccctcgct taaccttatt aacgccttct cttagattta tttccttttc 3524461 cgtgtgtatg gaatacgtgt ttagaaccct tagctcttga acttccataa gctgtgatta 3524521 ctttacccct tttatttaaa acaactgtag ctttttttcc aacatatttc gttgccccat 3524581 taggttgttt tattactttt ttagggcttc gcacagcatt cagtttggcc cttaaattga 3524641 ctccacggcc tccatttctt cctatagatt gattaagtcc atgtcttgta tgacctgtga 3524701 ttttaactgc cttcttcgta aacttatagg cgcgactagc acccttaaat atcttcccag 3524761 gaccaaaatt agaagcagct gcccaagcag cacctttcca tcctttacct gatttatatg 3524821 ccttatatcc atcataggct gcaaatccgg catttaccac aagccatacc caatgcccgt 3524881 ccggatcaac attcatcact gggttattat ttccataagc atacccattc tgatccaatg 3524941 aatctccgtc gctgcccggg tctgggtcga gcgataggaa cacgccgttt cttggctcgt 3525001 agtagcgggc catgagatag tacaggccgg tttcttcgtc gtattggtag cctgcgtagc 3525061 ggtagcgatt gtcttttact tcgtcgcttg cttcggtttt tgttggattt ccccatgcgt 3525121 cgtattgata cttggcaacg gtttttccag tgctgtctga gatcgcgatg atgtcgccgt 3525181 gagcgttgta gtgatagaaa tatttcttac cattttctgt gtaggataac agctggccgc 3525241 tgtctccgta cgtgtatgat tttgtgacgt tgttgtccgc gtctgtttca tacaagacgt 3525301 tcaagctgtc tccgtcgtag aagtagttcg tgacttttcc gttgacggtt ttttggattc 3525361 tgtttccttt ttcgtcatac ttatatgttg cgaatggctt gtcttcgcct tttttggtaa 3525421 cggcggtcag gttatcttct gcatcccacg tatatgtgaa tttgccgtcg gatgtgcggt 3525481 tgccgttttt atcgtaagag atgctttcat cattgacttt tgtcagctgg ttcatgatgt 3525541 tgaaggaagc gttcaccgtt ttgcttgagc cgtcttttat agttgtaacg gttttccggt 3525601 ttccgaatcc atcatatgtg tattcaataa cagtaccgtc ttcatgggtt tctttgacaa 3525661 gctgattcag cttcccatac tcatattgca ccttgccgct tgctgagctg tttatcgttg 3525721 tgcggttgcc gttggcatca tattcatagc tttccgtcag aatgtctccg ccgtttttgt 3525781 caccgatatg cagcgagctt acaaggtttc tttcgtcata tgaaaaactt gttccgccgc 3525841 cgttgcccgt aataaaggtt tggacgtttc cattttcatc ataatcaaat gaatatgagg 3525901 atgtactgtc tttcatctca atcatttgat ccagcttgtt atacgtaaat tgattcgttc 3525961 ctttttggtc cccatgaatc cacgagaagg ttttcagctt atcggagtca ctaggatatg 3526021 tccaagtttg gctgccgccg cggtctgtca gttcggttaa acggtttttg ttgtcaaatg 3526081 tccgtttctt tgtggtgttc tgctctttat tgacgaccga cgtttcattt ccatttttgt 3526141 catacgtgaa aatgtacttt tctgtaccgt tatacgactt tgatttcacc cggtctgttc 3526201 catcataaga aagagacact tcgttgccat ttggtgaaat ggttttggtc aggttgctgt 3526261 tggcatcata ttcgcttgct aacacattgc cgagagggtc agttgttttg acaagcttgc 3526321 ccatgacatc atattcgaat ttataggttt gatctgctcc tgcccggatg gttttgctta 3526381 cctcattgcc ttccttatca tagctgtgaa ggatagacgt gccgttagag agcgtcatgt 3526441 ttgtcaattg gtctgcctga tcatacgtat aggttgtttt ttcacctttt gcatctgttt 3526501 cagacgtttt cttaccagtt tcatcgtaat cagttgaagt ggcgtaacct agttcgtcct 3526561 cttccttggt cacatagttg ccattactgt catacgtgct tttagtcaga aggcttcctt 3526621 caatcaaacg gatatcatca aaccagactg tgcctgtcgc actcttttgg aacagaatac 3526681 tgatatcgac tttattgatc ggctttgttt tagggatgac gacagctgct cggttccatt 3526741 cctgtgttcc agaagggaat ttcgcattgt agatgcctgt gctgccgtca gcgtaagtga 3526801 cattcgcctg cagagaatag tctttttcat ctgtaaattt gacgctgctt gctttcgaca 3526861 ttcctgtcag tgtgagataa accggtttgt catttgcgct ttgccctaag acaacggttt 3526921 gttttgttac tgatccggct tgggacgcac tggtccgggc agcttttaat gatacatcat 3526981 cattaaagcc ttcttcagaa tcaacggatg ctccgcttac attccagttt tccgttgctg 3527041 atgtgaagct gctgttttga actgggttat agcttgatga tacttcgcct ttttccagct 3527101 ggacttcatc aaaccatgct tttcctttgc catctttatc tttatgatcg acttccatat 3527161 acacaacagc tttgcctgca ttcgctggag tcgtaaaagt gatttgccgt tttgtccagt 3527221 cattttttcc ggctaatgca ctgtattcat tgtgaatcca ttgaattcgt ttttgatctt 3527281 tgtctcgcaa atcaatgtta aaataggctc ttgatttcgc aagatctgtt ttgattttcc 3527341 cgcttaatgt ataggttgta ttcggctcca gctcaactgt ttgtgttgct gacgaatacc 3527401 catgatctgt tccggcagac gttgattggc tcaagacctc caatgccttt gatccggaaa 3527461 gaactccgct tttatcggcg atgactgaaa ttttgccgct gtctttagag gcagtcagat 3527521 tccagccgga tttttgagct tcaaagcttc catctttcaa aatattagtt gaagctgata 3527581 aatctttgct cgattgaatc tggtttccat atttatcata aacagctgct gacgatgatt 3527641 ttccgctctg atcggtttcg gatacagcat ccagtccgtc ataagcaata tccgtgacat 3527701 tgccctcggt atccttcatc tttgtgacat cgttgttttt gttgtattcg tatgtctcag 3527761 ttccatatgc atctttaacc gacgtaacgt tgccatcttt gtcatattga tagctttccg 3527821 ttgcttttcc ggtgccgacg tcatttggat ctacatcttc tacaacattg ttgccttcat 3527881 actttgtatt cgttgtaatt tttaaccctt ccgcatcatc aatgacctga atcggatttc 3527941 ccgcttcatt atagccatac tgtactttcc ggccatttgg ctgtgtcatg agaagcgtct 3528001 ttttatcagc atcatagctg tagacatatg tttctttttt agcgttgatc gctttttcga 3528061 gacggtgacc gctatactga tattcggtaa agacaggctt tgcttcggta ctgttagctg 3528121 aatattgttt gacaaggcgc ccttcactat cgtagtcata gcttgtgaca gtcccgtctg 3528181 tatctgtaac cttcttcagc aaatcattct catatgagta ggtgactttc ttattcttag 3528241 gtcctgtgat ggacgtcaca tggccgtttt catcataggt aaatgtaagc ttgcggcctg 3528301 atgcatctgt aatggcggtc agttgatttt tgtcattgta agtatagaca gttgcattgt 3528361 tatggccatc cactaccttt tggagtttgc cgcctttttt attgaaataa gcgttggttt 3528421 gatcctttgt ttttaatatg aactgatcag ctgtttctgt taattcaaga tatacaccgg 3528481 tcggcggctg atacgtgcca tcggcttttt tcgtgaatcg atgtgtcgta gcgtcttcat 3528541 cgatatacat tgccccgcca tccgttgaga tgacagatgt ttctgcatca gcataccagc 3528601 cttgtccaaa taagtgatca gagctgtcaa gactgttgta ggttctcgat aagccaagtc 3528661 ccggaccgcg tccatcaatt gacaaatctt cttcattcac aatgacattg cctgtcgcac 3528721 catttaactg gccgcttggg atatcaatga tagaccagta ctcttctgta cctaggaatt 3528781 ctgcgccttc atggaacgtt gggttaaagg gcgccgttgg aatcgtttca ccattcgcat 3528841 cataggcgac aagcgtgaaa gaataattct tcttcccttt gtaattccca tttgcattgt 3528901 tatagacagg tgatggatcg agggctaatt ccccgccttt tccatctgta tgaagcttat 3528961 agcttccggc tttgatttcc tcagaagtcg gccagatgtt tttattttgg gttgtccaat 3529021 gatcagcatc accaacatca aaggactgat attctttacc gttgtaaatg ttaactttat 3529081 agcccttcgc attttgaacc ttttcccata tcaaattcac ataacccgtt tgactcgatt 3529141 ttgtatttgt atacaaatag ccagttacat tctttggcct agcgatatca ggaagtgccg 3529201 gggtagcagc cggggatgca atggcttcgc cgtctttgtt gtatgcgata attttaaacg 3529261 agtaatttct tttggctcca tctcccccgg cgtttttata ggttggtccg ggattgatcg 3529321 gcagctctgc tccgcttccg tcctttaggt gaagagcata ttttcccgcc ttgatttctg 3529381 cacttgtcgg ccagatcttt ttcccttttg tggtccaaga cgtctgattt ccgagatcaa 3529441 gtgtctcaaa gcctttccca ttgaacacct gaaccttata gccggttgca ccggatacag 3529501 ctttccaaga aaggtcgaag tatcctgtgg cattcccatt attgtagccc tttgctgacg 3529561 gtgcttgtgc ttttcctaca ttagggataa cgggctttgc cggtgcggac atcgctcctt 3529621 caccttggtc aaatatcgca ctgacgccaa tccaatagtt tttgcttgta gcatagcttc 3529681 cgccggaatt cttatagacc ggggatggat ctaatgccaa ttcagctcca tccttgccgt 3529741 ccagatgcag tttatatctc ttggaggcaa tttctgcgct cgtaggccag atttttttac 3529801 cttttgtgct ccacgacgtg acgttgcctg cagaaatcgc ttgatattcc ttaccattgt 3529861 aaatccatac cttatatcct tttgcgcctt caaccttttt ccagctgata tcgaaataac 3529921 cagtggaatc gccgttgtga taggctttga ttgtaggtgt gtttcccttt ggaatggtat 3529981 acgtcacttc aatatatggt ttattggcgg agttcgctga agaaattagt tttttccaat 3530041 attccttgcc gtttccgttt gtatgaagct taaatccata gttggccccg ccggagttcc 3530101 atgactttac agcagcggtc acatcataac tcgcccactg tcctttatgg acgtcggctt 3530161 ttccgatatt tttagatgcc ggtttggtgt tccatgtcac ttttgcatta tcataattgc 3530221 tgttgaccgt atccagccaa aggccggttg cctttgttcc ataataggaa tgggctacgt 3530281 atgtttttaa tgtagcttta gtgacagtca tattttgaat tggctttagg ttgttaaatt 3530341 tcatgaacgc atagtttgtg cctgttgttt tgtcataata gcccgttttc agtacatagg 3530401 cctttaaatt agcatcccat ttttgtgagg aggccgaata gttcgtcgtc gggtaggcac 3530461 tcatgacaaa cgtatccgat gaaacagata aagaagttga cgggtcgata gatactggat 3530521 atacgcgttc tgggtctttc agccagttct cgtctgccgt aagatgaagc aaataccctt 3530581 cttcattctt ttccagctta tagctgactt tgtctgaccg ttcaacctcg ccggaaagct 3530641 catctagttt tgaatccgtc ataaaaggct taggcacaga aaaaacaact tttccttttt 3530701 catcagaaaa atcaatggat ccatcctctt gttctttagc ctgcaaatcg gtttttaact 3530761 gaaatgtaaa tgtgttgtat ccattatact gatgaaggac taaatcttct tttatgtttt 3530821 cattgaatgt gaaagtctga agatcaatat tcggaaacac atccggatac acaatctcat 3530881 tactgtcagt cttataatct gctgaggtat ctttcggagt aagtgaagtt ttattcgggc 3530941 ctttcgcttc tgctagtgaa tatgtaacct tatggtcatt atgctcaaaa gtcgcataaa 3531001 gcccgttctt catttgcttt tgaaaatctg aattcaaaat agcgttctct gtctcgactt 3531061 gtttgcttgt cgactctttt aactcaggag aaatgtcttc ccagtcggca tccggtgttt 3531121 cctttgtatg aataggatca aggtatactt cctgtttata gacaccgtca ccttcataat 3531181 agagttttgt attttctgtt ctttcagagg tgatctcacc ctctttgttt atatcttttg 3531241 gatcaaaagg tacagcttcc tcagtttgtt ctttctgaag agtttcttct ggatcatcgg 3531301 cagcaatacg gtttccattc tcttcttctg tagattttgc tagtacatcg gctggcacta 3531361 atgaaatcat taaagccaac actaaaaatg ctgcaatgaa ccttttaaag tttcgcctct 3531421 ttcttttttt catttcctct ctccttttgt aataaaagta atatttactc aataatctta 3531481 actagactga aatatcatta caatattttt ctagaaaatt tatcttattt taaggattag 3531541 cgagagtcaa ttgacctaaa acaaaaaaag gccgcatagg cctttttaca ttttttattg 3531601 tatttgttca atatccgtac cctcagctgt cacattcgcc ttcccctgcc tcctgacaag 3531661 cgtcaaggcc atgcccgcaa agatcattac gatgccaagc gtttgataga ggtcagggcg 3531721 gaagcctgtg aagacggtat cgagcacgat cgcgacagcg gggtcgagaa atacaatgat 3531781 tgaaataaat ttcgttgata aaaatcgtaa actgtcaaaa aacagcaaat atacaatacc 3531841 cgtatggatg atgccggtag ataccaccat aatccagttt ccctgagata ggtccgcaaa 3531901 agcgccaaag tgaataaacg gaatcaggat gataacccct aaacctgtct gcaagaaggt 3531961 ggtcgtgtaa ggactgagat tgtgaatgcc ttttcccaat aaagtggtga acgcataaaa 3532021 cagtgcggcg agaactgccc atatgatccc tgatcccatc agctgtgtca atgatgtgct 3532081 gccgttaatc ccggaaatca gcgcagtccc aagaaagcag atgataatgg agctgacgga 3532141 gatcacattt aatttctctc tgtagaagaa gctccccaga agaagaacaa gcaccggcgc 3532201 tagatgataa acagagatgg caattgtaac ggacgtttct tcaaaagact taaataagaa 3532261 cacccagttg aatacaagaa agaaaccgca cgccaatgtt tgcagcacgt ctctcttgct 3532321 ccatttttca gttttatact ggccggacgc cagccagcaa aagcctaaaa acagcgtcgc 3532381 gcaaaggcag cggacaaaga ccaattcaaa tgacggcaga ttggtatgct ctgagaaaaa 3532441 gccgatggag ccgaaaatca ccatagagat gaccattttg attacggctg ttgatttttg 3532501 ttttgacgat atggaaggat cctgttgcat caaacgtatt ctacctccaa tactgcatag 3532561 cataaactgt tttttgtgaa ttcagaaatc tacacataga attcctcttt tttacatgta 3532621 gatattataa cacttctatt ctaaataaaa aaaagcgccc aagggcgctt tttttacaaa 3532681 tctatcgaac aatcaaaacc gggcatgttg ataattgaga cactttatgg ctgacgcttc 3532741 caagcatcat ttctttcagg ccgctgatcc cccggctgcc aactacaatc aggctgacgc 3532801 ctttctcttt tgcgtgattt agtatctcat gcgccggctc gccattcgcg taaatggttt 3532861 cagcttgaac gcctttttcg gctgcttttt cttttgcatt ctcaaggatt ttcaggccct 3532921 cttttttaac ctcgttcctg atttcatcaa taaagtgttc aggcacatag acaattcccg 3532981 tcagagaaga agtcgtgacg acggcttctc tccccacatg aagaatgctt agttccgctt 3533041 gttgctcttt tgccaaatgc actgcggcat caagcgcttt tgcactcatg tctgatccgt 3533101 caatcgctac taacattttg ttaaacatgc tcttcccgcc tttcggactg tgggtggttc 3533161 atctttctct tttattgtcc gcctgcattt cgttattgtc aattgaagcg catgagtttt 3533221 caaaaaattg tcagagactc tctccgtttg tggcgataac ctgctgatac cagttgaagc 3533281 tttttttctt gatgcggtta aatgttccat ttccttcatt gtcccggtct acataaatga 3533341 agccgtagcg ctttttcatt tccgcagtag atgcgctgac aaggtcaatt ggcccccatg 3533401 atgtgtatcc gattaattca acgccgtccg caatggcttc gcgcgcttca attaaatgat 3533461 cacgcagata gttgattctg taatcgtcct gaatcgtgcc gtcctcttca accttgtcta 3533521 cagcgccaag gccgttttca acgatgaaca gcggcttctg gtaacggtcg tataaggtgt 3533581 tgagcgtgat gcgcaagcct ttcggatcaa tctgccagcc ccattctgat gatttgaggt 3533641 aagggttttt gactccgccc agcaggttgc cccctgattt tgcaagctct tccggatctg 3533701 tgctcgccgc catcgacatg tagtagctaa atccaatata atccaccgta tgttctttca 3533761 agagctcttc atcgccttca gccatttcaa tttcaatatt gttttctgcc agatagcgtt 3533821 tcatatatcc cgggtatgcg cctcttgcct gaacatctga gaagaaaagt gttttgcgct 3533881 cattctccat tgccgcgaag acatcctccg gcttagaagt catcggatag gttgtcgttg 3533941 ccgctatcat acagccgatt ttcgaatcag gaatgatgtc gtgacccgct ttgacagcaa 3534001 gagcactggc cacaaattgg tggtgtgccg cctggtacat cgcgtttaat ttgttttctc 3534061 cttcttcaaa aacaagaccg cctccggtaa atggcgcatg gagcactacg ttaatttcat 3534121 taaacgtcat ccaatacttc actttgtgtt gatagcgttt gaaaaccgtt ttggcatagc 3534181 gttcataaaa ctctatgact ttgcgattct tccagccgcc ataatttttc actaaaccga 3534241 gcggcatctc ataatgagag atggttacga caggctcaat atgatgcttt aacagctcat 3534301 caaacagatc atcataaaat ctgaggcctt cttcattggg ctcctcttca tcgccattcg 3534361 gaaaaattct cgtccacgca atcgatgtgc ggaacgcctt aaatcccatt tctgcaaata 3534421 aggcgatatc ctctttataa cgatgataaa agtcaatccc gttgtgatac agattcaagg 3534481 aagtcattga ttcatcaaat ggagacatga tcccgttcgg cgatacgtca gctgtcgaaa 3534541 gccccttacc accctcgtta taagcaccct ccacttggtt ggcagcaact gcgccgcccc 3534601 ataaaaatcc ttctggaaat cgtttttcat ttgaactcat attgatcacc ccattagttt 3534661 tttcaagata aagcaagcag cgcttctttt ggctgcactt taccgatctc tttcaccggc 3534721 gaaaacgaat attggtctgt gttggtcaca atcaccgggg taatgacgtc atatcccgcg 3534781 gctttgattt gctccagatc aaaggacacg agcggatctc ccggtgcgac cttgtcgcct 3534841 tctttgatgt gagccgtgaa ccattgtccc tccagcttta ccgtgtccaa tccaatgtgt 3534901 atgagtattt cagctccctg atcactcgta atgccaattg cgtgttttgt tttaaaaatg 3534961 gtggtaacgc ttccacgaac aggcgaaaca acttctcctt cttcaggctc aatggcaaat 3535021 ccttttccca tgaccccagc agaaaacact ccgtctttga cttcacttaa ggctttcact 3535081 tctcccttaa tcgggctgtg aatgatctct ctgctgcctt catgcactgc cggctgctgg 3535141 ctgccgtcag aaggcacatc ctcgaatcca agcaaatacg cagctgctgt tcccgccgca 3535201 aacgcaatca caaggccgat catcgcgtaa ataaacgttg ggccgataaa gacagggatg 3535261 ctcggcagac ctgcattccc cccgacgata taggaagcaa cacccgtcat gccgtaaaac 3535321 gcgccaccgg ctgcaccgcc aatcaaagcg gccgcaaacg gctttttcaa tcgcatattc 3535381 acgccgtaca tcgcaggttc tgtgatcccc atcagcgccg tgatgcttgt ggtaagcgcg 3535441 agtgatttaa attttttgtt tctagagcga aggaagacgg caaatgatgc tcccgcctgc 3535501 cccatattcg ccaaaaacat agccggcagt aaataatcgt ggccgttttg agcgatgttg 3535561 ttgatcatga tcggcacaaa ggcatagtgc atgcccgtca taatgattaa agagaatgta 3535621 cccgccagca aaatcattgc cacaagccct gcatgatcaa acaaataatt gaccccagaa 3535681 gacaagtatt ctcctaaaat agcgccaagc ggaccgactg taatcaatgt cagcggcacg 3535741 acaatcaata gcgtgaatgt cggaaccaca atcaatttga gagatgcgtg tgtaaaacgg 3535801 tcaatccatt tttccacgta tgaagcaatc caaatcgaca gcaaaatcgg gatgaccgtt 3535861 gacgaataag tggcagcggt tacaggaagc ccgataaagg aaatcggttt ccccgcaccg 3535921 agcagggctg tcaaatccgg atgcaggatc gccgccgcaa tggcagccgc tacgtacgga 3535981 ttgcttccga attttctcgc cgcactcatc gctagcagga gcggcaggaa gtagaacgca 3536041 ccgtcaccga cagccgtcaa aatgacatga acctggctct tctccgccat ccagccaaac 3536101 gtgactgcca gcgccacaag tcctttgatc atccccgctc ccgcaatcgc aggcagaata 3536161 ggggtaaaca ccccagaaat cacatcaaag accgcactca gcacattctt tttctgagag 3536221 gatgaaccag cgctcttttc atcactgaga ttgctgtgcc gcacaatcgc ctgatacacc 3536281 ttcggcacat cgtttccgat aatgatttga aactgctcgc cgctgatatt ggtgcccatc 3536341 actccaggca gctgctccag ctgactgcga tccgccttcg cgttgtcatg aagattaaaa 3536401 cgcagcctcg tcatgcagtg gatcacgcgc tgaacgtttt cttcaccgcc tacgagttgt 3536461 aatatgtcct tcgataattt atcataatcc atgtgtatac ctccttttta tggggggact 3536521 gctggatgaa aggtggccgc ctttcaccag ctttttttgt atcaaatgct gcatcacctc 3536581 ctaaaagaga ataaaaaaac ctaaatgaca cagattgcga gagtctcctc ctgcacctgc 3536641 accatttagg ttttgcctgc tttcgcagta acaatcctga cgggtcgttt tatttgtttg 3536701 taggtatact ttagcactag attcgtgaga tgtcaacgct ttcatttttg gtgttgacta 3536761 tcgtttctag aacaaaagta atcataaaga tttgaactta gtattaactt caataaaaaa 3536821 ttattgtaat taaaaacctt gaaaggcatt ttttccaatc aaggttatga atcgttaccg 3536881 tttaaatttt tttaaagact tctttatctg tactattaca ttctttagcc aatctattgg 3536941 ttctaaatta aacgcaggaa gatacacgcc atctgcgcaa gattgaatgt aatcgttttt 3537001 cttattgtct gaatgctcac tttcaataaa atccgttaaa aagacaatag catcctccaa 3537061 atattcctta ctttcctcta ttaataactc ttgtatagcg tcatcaggag tttcaatatc 3537121 ttgatggaat gttccagcta aaaactgaaa aacagggtcc ttctgtttat tgatcaataa 3537181 catgtcatct tgctccttta agggagaggt aacgggataa tgttaaaatc attcatcatc 3537241 taataaatca agataatact gatcattctc ttctattttt cttaagaact cggtaagaga 3537301 agttgcaatt tgaatatcat aatagtaaat cggattttta ttattatcat ttaattcaat 3537361 tgacattaat gccgattcac taccttcaaa aaatattaat ttatcattct caaactcatc 3537421 atatatttct atgtcaggat aaaattcaaa gtcatttatc ctcaatcgaa agtctcttac 3537481 agaatatgga tccaaaatgc gattagtatt aaactctgat cctttaataa acccatagcc 3537541 aacttctaaa taaaaattca ctaattcact aggtaatttt aagtttaaat ttttttcaac 3537601 ctcttcaatc tcactttgat tcactggata aaaatcattt tctttgtttg attttataaa 3537661 attataactc attttttttt gcctccttta aataattcat ttgctggtga gcctgtacca 3537721 tgaatcccag cttgatgctc gttaggaaat tttgctggat gcatattcca ccattcatgt 3537781 tctccgccaa aagtattttc aattatatgg tgagcatcat acttatcccc tttttttcta 3537841 ataattttac ctgttttttc agatacaaca ttttccttat aaacaggcca tttttgtcca 3537901 gtgttttctt cccattcttt tataacttta ttttttactt tatcaaattt agtcctgtgt 3537961 tttgcagtct ctattggtga cattttttta tattctttat ttcttaatgc ttcctttaat 3538021 ttatctattt gatttttagg taattctcta cctgtgcgtt gttctatatc tctagcatac 3538081 ttttttatta aatcagaatt aattttatta gcagatccac ttacatcatt cgcaattttc 3538141 cctttatcct tagcaacgtt tttaacttcc gaagccttct tagccttttt cccattatta 3538201 ataagtttat taatatctat taacttttct aacttagcta ttttggcaaa tggtactgag 3538261 tttatggagg caacaacacg gtctttccct gtgacttttt cgcctgatac cggatctctg 3538321 cccgtggctg ctttaaatag atcatacacg ccggtaagtt ctacagccgt ctctaaaatt 3538381 ttcacatatc cattctcatc cactttaatg tccgaaagcg agacgacagg ttcaagcttc 3538441 atgtcattac cagatatgta tacattgtaa agtgtatcat tataaacgac ttgcttaacc 3538501 tctgcatttg agaaatcagt ttttatatgt tctctatgtt cactcgtatt atacacttta 3538561 ccattgataa cgatgatatt tttacttacc tttttagaat cacccgtttt gacaactgaa 3538621 tccactttag acttttcatt ctcggctaat ttcttcagca tcatctccat cggtgaatca 3538681 tccgcctgct tcatttgcgg gttaatcgcg ccgaagattt ggttgatgtt ttcttcttcc 3538741 tgtgatttca ggatggagcc gcttttgtag cctgtgattt caattttcgg gccggtgtac 3538801 atggtttcga gctgatcaat gtattttttc atcgtttgaa aatctgattt tgcggcttct 3538861 agtgcttggg tttgctggcc gtcaaattga aagagcttat tcagggtgtc tgaaatcagc 3538921 cgctcagcct gttctgtttc catccgaaaa aaggaatcat tgactgtcgg caggctgacg 3538981 atgtgatcta tggctgatgt ctggcgattg actgcgtcag tgagctgctc tgtcacttct 3539041 cgtgcatgct tgaccccatg tctcgcatcg tgtgagagaa aagcctctgc gatcatgccg 3539101 tgggagttag attctacaga ggaaatcgca tgctgtgttt gtttcagcac ttttttgtat 3539161 tcgtcgataa atatgccaaa gaaaaggaga aaaggcttgt ggcactcctc gtaaaaggtc 3539221 cggatggcat ctccgccttt tcctttcagc gcatccttca tgcctgccag atgctcaacg 3539281 cttttttcca gcttctccag ctgttgtttt tgcttgtcca gtttctcaat cgtatgctga 3539341 atgccctcgt gaagagcgtg gacatctaat gttttcaatc ccttgtcctc ccgcgcttta 3539401 tttcatggaa gatgatatgt tttcgtccgt ttccttcatg gcgtttaccg cgctttccgt 3539461 ttgtgcgata tgcttggcca gaacagacgc atatgcttca gtgagctctt tgatgtcctt 3539521 atttaattgc tcgatggact tcacaacatt caaatggttt ctgcctgaga gatgaccggg 3539581 caatgaggac ttgagttcag ctgaattctt gagctgagaa agcccttgct tcactgtgtc 3539641 atacaccatt ttaatttcct gtgccatttg tgctcacctc actttttatg tttttccttc 3539701 tctatttcat gctctatcct cgtgatttgg cgtcttatag aatacacatc gccctctaat 3539761 gagtggattt ttccttctat gctttcgatg attccgctga cttgatcgct tttgatttgc 3539821 tgatatgctt tgttcattcc ttcacgaata tcttcaaacc gctcagcatg tgttcctctc 3539881 catgcctccc ggttaagatg aggccggtga atgagatgct gggcctcaga gaaatcgtgt 3539941 ttgatttgcc taatttcgtg cagcactcgt tttaattgat ggatctgttc ctgcttttca 3540001 tgtaagtcgg cttttaccga atgtaacaac atttcactat gcatgccgca acacctcgtg 3540061 tttctatcaa actgtgtaaa ttctttacaa tacagactat tttcatatta catgatgggt 3540121 catattggat aaataggtaa aaaggattgt cttgagaggt atagaactgg ttctaaattg 3540181 ctaaaaatac gatctcatca ccctatgaaa ggagaaaaca atcatagtag ggacttttta 3540241 tttaagcctt taatctctcc tccagttcta atttttcctc ccacttaact gtttcttata 3540301 gtcaataaag ctcataaaaa aacaccttcc ctcgaaggcg cttctccatc ttatttagat 3540361 ccccatacag cctcaccgct ggtattcagc acactaaacg tcatgacgtt cttctctctc 3540421 accgaatccc actggcgtaa aaataccccg ttatacttct tgcctgctaa cgtgatgtcg 3540481 gcggtgtttt ttccggtttt cctccatgtt ccggtcattt ccccggaaat ggtgtggttt 3540541 ttgttgagct ggatgttgat ggtttgtttg atgtcggctg agatgtcttt tccgtgctgg 3540601 ataagtttgt atgttcctgt gatgtctttt tgttttactt ctttcaatgt ttcgcccgca 3540661 taacgatatg gtgctgctac cggccagccg tctttgttca tgaacaattg gtggactctg 3540721 acttcgtgtt cttcacccct gcccgggaag cgggtgtgga agattaaata ggaacgcccg 3540781 gttttttcat catagtatgc ggagttgtgg cctggtgaga cgtacccggt gcctttttca 3540841 ttttctgttt caaaagtgta gctgcccatg agtttgacgc cgtatggttc gatggaacgg 3540901 tcgtcgaaga atgtgcctcc cttgccgcgg acgtcgagca ttggattgcc ttctgcatca 3540961 tagtaagggc cgtccggttt cttggagcgg gccacacgga tgttgtagcc gcctgttgca 3541021 tcgagaccgc catatgatag gtataagtag tagtattggg tgtctggatt gtagagaaca 3541081 tacgggcctt cgattctgct gtggttgccg ccgagcagtt ttttcccata tccctgtcca 3541141 ggaagcggga agcccgtttt cggattcatt tcaagtatga aaatgccgcc tgagtatgat 3541201 ccgtacacca tccacagctt gccgtcttta tcaaagaagg tatgcgggtc gacgacattc 3541261 ggatgtttgg ttgcatcata cggtgttcca tcgctgcttg tgccttccat tcctgatttc 3541321 aaaaagatgc ctttgttttt gtatgggcct tcgatgttgt cagcaacggc aacacccatg 3541381 gcggatcttg gcgaatcgcc gcggcaggcg ttgtagtaca tgtagtattt gccgtccgcc 3541441 agctgcgtga cgtcagccgc ccaaagagta tcggattgcg cccattcgaa ggtttctttt 3541501 aattcttcat agacattcgg gataagtggg ttgtcattgc ttacgctggt ggtcagctgc 3541561 tgccattgca tgaggtcatt cgatttagct gaagcgagat gagatccaaa aacataaaaa 3541621 gtgccgtttg tttcaatgat ggaagggtca tggacgctga cttctttaaa tataggtttt 3541681 tgtgcataga cggagtttgg gagggtgaag gccatgataa gagctgcaag aaaacataca 3541741 cggaacaatc ggttgaacat ctaaacaatt cgcctctctt ttttattaaa ttttaaacgc 3541801 ttacatttct ctatgaagat accccggcct attaaaacag ccgaatgttt tcatattcat 3541861 ccagataggt gatttctcac ttcacttaca tagtcagact gatgtctgtc tgttttgcgc 3541921 agaacttgtt gcttgcatat cctctccttc atagttcaac tcttttgctg tttctccttc 3541981 ttgcatcacg tctgtttttc tttcgcgtac atgtaataac tgctttgtca ggttttgcat 3542041 caactgtgat acagccattt cgttgtcggc gttttttaag atgatgcctg attgcccgtc 3542101 aacaccagag tcattcggct ggctctttat aaaacgcctt gcgaaaaata cgacttagta 3542161 aacgcatatt gagagttaga cagcggcgct tgcctccttg tctggatatc gtgtgcaatc 3542221 gctgaaaaaa cctgttctgc tttctgcgtc acgctattac aatagcaatc taacttgtta 3542281 aagactataa aaaaaccttt tgacttctgc tgctgaacca attaatataa tactcagtta 3542341 atagttatca gaatttttag gaattgagtg attcatatga cactgcataa agagcgtcgg 3542401 atcggccggc tgtctgttct cctgctgctg aatgaggcgg aagaaagtac gcaggttgag 3542461 gagctggagc gagacggatg gaaggtctgt cttggcaagg taggatcaat ggacgcacat 3542521 aaagtagtag ccgcaattga aaccgcttcc aaaaagagcg gtgtcattca atctgagggt 3542581 tatcgggagt cacatgcgct ttatcatgcg acgatggagg ctttgcatgg cgtgaccaga 3542641 ggtgaaatgc tgctgggatc gctgcttcgg acggtgggat tgaggtttgc cgttttgagg 3542701 ggaaatcctt atgaaagtga agcggaaggc gattggatcg ctgtctcgct ttacggaaca 3542761 atcggggcgc cgattaaagg tcttgagcat gaaacattcg gcgttggaat taatcacata 3542821 tgaaacagcc catagatctt agacgatagg gggctatgcg tgaaaacaga agttcacagc 3542881 atagctcctt tttgtatggg cgctttacca aagtaaagaa aaaggagttg ggcttatggt 3542941 gactttagac ggttcttcat tgacaacagc cgacgtcgct cgtgtgctgt ttgattttga 3543001 ggaggcagcg gcttctgagg aaagtatgga gcgcgtgaaa aaaagcagag cagcagtgga 3543061 acggattgta cgcgacgaaa agacaatcta cggcatcaac accggatttg gcaaattcag 3543121 cgatgtcctg attcagaaag aagactcggc ggcgctgcag ctgaatttaa tcctttctca 3543181 tgcctgcgga gtcggcgacc cttttcctga gtgtgtttcc agggcaatgc tgcttttgcg 3543241 cgccaatgcg ctgttaaaag gcttttccgg tgtacgcgct gagctgatcg agcagttgct 3543301 tgctttttta aataaacgcg tccatcctgt catccctcag caaggatcac ttggcgcaag 3543361 cggagatctg gcgccgcttt cccacttggc gcttgcgctg atcggacaag gagaagtctt 3543421 ttttgagggg gaaagaatgc cggcaatgac aggcttgaaa aaagcaggta ttcaaccggt 3543481 aacgctgaca tccaaggaag ggcttgcctt gattaacggg actcaggcca tgactgcaat 3543541 gggggtggtc gcctacatcg aagctgagaa actagcctat caaacagaac gaattgccag 3543601 cttaacgatt gaggggttgc agggaattat cgatgcattt gacgaggata ttcacttagc 3543661 ccgcggctat caggagcaga tcgatgtcgc agaacgaatt cgcttttatc tatctgacag 3543721 cggcctgaca acctcccagg gagaactgcg ggtacaggat gcctattcat tgcgctgtat 3543781 tccgcaagta cacggtgcga cttggcagac actaggatat gtcaaagaaa aattagagat 3543841 tgaaatgaac gcagctacag acaatccact cattttcaat gacggtgaca aagtgatttc 3543901 cggcggaaac tttcacggac agccaatcgc ctttgccatg gattttctga aaatcgcaat 3543961 atcagagctt gcgaatatcg cagagcgtag gatcgaacga cttgtgaatc cgcagctgaa 3544021 tgacctgccg ccgttcctga gccctcatcc cggtctgcaa tccggtgcaa tgatcatgca 3544081 gtacgccgcg gcctcactcg tttctgaaaa taaaacactg gcccatcctg caagtgtgga 3544141 ttccattccg tcatccgcca accaagagga ccatgtcagc atgggaacca tcgccgctcg 3544201 gcatgcttat caggtgatcg caaatacaag gagagtcatt gcgatcgaag ccatttgcgc 3544261 attgcaggct gttgaataca gaggcataga acatgcagcg tcctatacga aacagctttt 3544321 tcaagaaatg agaaaagtcg tgccgtccat tcagcaggac cgtgtttttt cctatgacat 3544381 tgaacgcttg actgactggc tgaagaaaga atctttaata cctgatcatc agaataaaga 3544441 actaaggggg atgaacatat gactgatgta aaaaaatcaa tccgtgccaa cagaggaaca 3544501 gagcttgaat gcttaggatg ggagcaagag gcagtgcttc ggatgcttcg aaacaacctt 3544561 gatccagaag tcgccgagaa gccggaggac ctcatcgtat atggcgggat tggcaaagcc 3544621 gcacgggatt gggacgcttt tcacgccatt gagcattcct tgaaaacatt aaaaaatgat 3544681 gaaacattgc tcgtgcaatc cggaaagccc gttggcatgt tccgtacaca cccgcaggcc 3544741 cctcgcgtgc tcctagcaaa ttctgttctt gttccgaagt gggcagactg ggagcatttc 3544801 cacgaacttg agaaaaaagg gttaatgatg tacggacaga tgacggctgg cagctggatt 3544861 tacattggct cacaaggcat attgcaagga acctatgaaa ccttcgctga gctggcgcga 3544921 cagcacttcg ggggcagctt aaaaggaacg ttgacgctga cagcgggtct cggcggaatg 3544981 ggaggcgccc agccgctgtc agtcacgatg aatgaaggcg tcgtgattgc cgtcgaggtt 3545041 gacgagaaac gcatcgacaa gcggatcgaa acaaaatact gcgatcgaaa aacagcatcg 3545101 attgaggaag ccttagcttg ggctgaagag gcaaagctgg caggaaaacc tttgtccatt 3545161 gcacttctcg gaaacgcagc tgaggtgcat cacacacttt tgaaccgagg cgtcaaaatt 3545221 gatattgtga cagatcagac atctgcccat gaccctttaa tcggttatgt tcccgagggc 3545281 tattcccttg atgaagctga ccgtttgcgt caagacactc cagagcttta cgtgcgcctt 3545341 gcgaagcaaa gcatgaaaaa acatgtcgaa gccatgctgg cctttcagca aaagggctct 3545401 attgtatttg actacggcaa caatatccgg caagtcgcaa aggatgaagg gctggagaat 3545461 gccttcgatt ttccggggtt tgtccctgcc tacatccgcc ccttattctg tgaaggaaaa 3545521 gggccgttcc gctgggcggc gctttccgga gatccggcag atatttaccg tacggatgcg 3545581 ttattaaaag agctgttccc gacaaataaa gcccttcacc gctggattga tatggcacag 3545641 gaaaaagtca ccttccaagg cttgccgtcc cgtatctgct ggcttggata tggagaacga 3545701 aaaaagatgg gcctcgccat taacgagctg gttagaaccg gggagctaaa agcgcctgtc 3545761 gttattggga gagatcattt ggactgcggg tctgtcgcct ctccaaaccg ggaaacagaa 3545821 gcgatgaagg atggaagtga cgctgtcggt gattgggctg tgctaaatgc gcttgtcaac 3545881 acggcggcgg gtgcaagctg ggtttccttc caccatggcg gcggcgtcgg aatgggctat 3545941 tcccttcatg ccggcatggt tgcagtggcc gatggaagtg agctggctga cgagcggctc 3546001 gcgcgggtct taacgagcga cccaggaatg ggcattatcc gtcatgcgga tgcgggttat 3546061 gaacgtgccg ttgaagtagc gaaggaacag gacattatcg tgccgatgca aaaataaagg 3546121 agtgatgaca tgccaaagca aattgatacg attctcatca acatcggtca gcttttgacg 3546181 atggaaagca gcggtccgcg ggcaggcaaa agcatgcagg atcttcatgt gatcgaagac 3546241 gctgttgtcg gcatccatga acagaaaatt gtgttcgccg gacaaaaagg ggctgaagcc 3546301 ggttacgagg cagacgaaat cattgactgt tcgggacgcc ttgtaacgcc tggcctcgtt 3546361 gatccgcaca cccatcttgt atttggcgga tctcgtgaaa aggagatgaa ccttaagctt 3546421 cagggcattt catatttgga tattctggcg cagggcggcg ggattctgtc tacagtcaag 3546481 gataccaggg cggcttcaga agaagagctg ctgcaaaaag cccattttca tctgcaaaga 3546541 atgctgtcct acggcacaac cacagcagaa gtgaaaagcg gctacggctt ggaaaaagag 3546601 acagagctca aacagttgcg tgtcgcaaag aaactgcatg aaagccagcc tgttgacctt 3546661 gtttccacat ttatgggagc ccatgcgatt cctcccgaat atcaaaacga tccagatgat 3546721 tttctggatc aaatgctttc ccttttgccg gaaatcaaag agcaggagct cgccagcttt 3546781 gctgatattt ttacagaaac aggcgttttt acagtcagcc aatcccgccg ttatttacaa 3546841 aaagcagctg aggcaggctt cggattaaaa atacacgcag atgaaatcga tccgcttgga 3546901 ggtgctgaat tagcaggtaa gctaaaggcc gtctcagccg accatttggt aggtacatcg 3546961 gacgaaggca taaagaaatt ggctgaggca ggaacgatcg ccgtcctctt gccgggcacg 3547021 acattttatc ttggcaaaag cacatacgcc agggcaagag ctatgattga tgaaggtgta 3547081 tgtgtcagct tggcaacgga ttttaatcct ggcagctcgc cgactgaaaa tatccagctg 3547141 attatgtcca ttgccgcgct tcatctgaaa atgactgcag aagaaatatg gcacgcggtc 3547201 acagtcaatg ccgcatatgc cataggaaaa ggagaagaag ccggtcagct caaagctggc 3547261 cgctcagctg atcttgtcat ttggcaagcc ccgaactata tgtatattcc gtatcactac 3547321 ggggtcaatc atgtacatca agtcatgaaa aatggaacaa ttgttgtcaa cagggaggga 3547381 gccattcttg gataagtacc cttttctcag agaggccgga tcttcgttta aagaccggga 3547441 tgtcacaaaa atgagcgacc tgatcgcaac atgggacggc caggacatta agggaccggc 3547501 gttgataggt gtccccctat caaaatcctc catcagtcat tcaggcgctt cctttgcacc 3547561 cggaacaata cgccaggctc tgaaacattc atcagcctat tctgctgagc ttggagagca 3547621 cgtcgtatca gagcttctat atgacctggg ggatatcgat attcatgtca ctgatatcgt 3547681 aaagtcacat catcacattt tccaaaccat gcacgctctg ctttcggatc atccggattg 3547741 ggtgccgctc atacttgggg gagataactc tatcagctac tccacaataa aagcgatagc 3547801 acaaacaaaa ggaacgacag cggtgattca atttgatgcc catcacgatg ttcgcaatac 3547861 ggaggacggg gggccgacaa acggcacccc cttccgccgc cttttggatg aagagatcat 3547921 tgaaggtcaa catttgatcc agctgggtat cagagaattc agcaacagcc aggcctatga 3547981 agcatatgca aaaaaacata acgtgaacat tcacacgatg gacatgatcc gggaaaaagg 3548041 actaatccca acgataaaag agattttgcc tgttgttcaa gataaaacag atttcatttt 3548101 tatatctgtt gacatggatg tcttagacca gtcccatgca cccggctgtc cagcgattgg 3548161 cccgggcggc ctctatacag acgaattgct tgaagcagtc aagtacatcg cacaacagcc 3548221 caatgttgcc gggattgaaa ttgttgaagt cgaccctacc ctcgattttc gagatatgac 3548281 aagcagagct gcagctcatg ttctgttaca cgcattaaaa ggaatgaaac tctccccatt 3548341 caagtgatct tctggcaggt tgtattttgg gtataagaaa ctcatctgcc taaggaatgg 3548401 cagctaaaag gagggcgaga cagtgaatct tcaggagaac agcagccaac agctaaaacg 3548461 cacaatgaaa agcaggcacc tatttatgat ctcattggga ggcgtcatag gcacaggact 3548521 tttcctcagt acgggctata cgctacatca agccggaccc ggcggtacga tactcgctta 3548581 tgtaatcggc gggttgatga tgtacctcgt catgcaatgt ctcggcgaat tgtcggttgc 3548641 catgccggtg accggctctt ttcaaaaata tgctacaaca tttatcggtc catctaccgg 3548701 ttttatggtc ggcatcatgt actggatcaa ttgggtggtg acggtaggct ctgagtttac 3548761 cgcatccggt attctcatgc agcgctggtt ccctgacagc agtgtatgga tgtggagtgc 3548821 gatttttgca gcccttcttt ttatatgcaa cgcattttca gttaagttat ttgcggaaac 3548881 tgaattttgg ttttccagcg taaagattgt caccattatt ttatttatca ttttaggagg 3548941 agccgccatg tttggcctga tctctttaaa cggaacggcg gatgctccta tgttgtcaaa 3549001 cttcacagat catggcgggt tgtttccaaa tggctttctc gccgttttta tcgcgatgat 3549061 atctgtgagc ttcgcctttt ccggtacaga gttaatcggc gttacagcag gagaatcagc 3549121 aaatcctcaa aaggatatac cgcgatccat ccgtaatgtc gcatggagaa ccgtgatttt 3549181 tttcattggc gctgtcttca tattatccgg gttgatttca tggaaggacg caggcgtgat 3549241 tgaaagcccg tttgtcgccg tatttgcgga gatcggaatt ccttacgctg ctgatattat 3549301 gaatttcgta atattaacag ccttgctgtc tgtcgccaac tcaggcttat atgcttcgac 3549361 ccgtatgatg tggtctttag caaatgaaaa catgatcagc tcccgtttta agaaagtgac 3549421 atctaaaggc attcctttaa atgccttaat gatcagtatg gctgtatctt gtttatctct 3549481 cgtttccagt atcgtggccc ctggaactgt ctatgtggtg atggtcgcaa ttgctggatt 3549541 tgcaggagtc gtggtctgga tgagcattgc cttgtcccaa ctcttgtttc gaaagagatt 3549601 tttgaaaaaa gggggggatg taaaagatct gacatttcgc acgccgcttt atcctcttat 3549661 gcctatagcc gctctcttat tatgttctgc ttcttgtatc ggtcttgctt ttgatcccaa 3549721 tcaaagaatc gcacttttct gcggagttcc ttgtatcatc ctttgctatc tcatctacca 3549781 tttcaaaaga aatgttacaa aagcgaaaaa aatcagccaa gaggaatatc cagccgatca 3549841 catcctataa ttaaaaaagc acaccccgct cagcatggga tgtgctttat tttttattct 3549901 gtaattaacg tatgaatcag cttcggcgcc ttcgcttccg cggcgatgcg gatgttgtca 3549961 tagacttttg cgatgacttc atcgacgttt tctcggttag cgtaaagcgt tacgagcggt 3550021 tccccttttt ctactttgtc gccgaccttt ttgcggagca tgatgccgac ggctaaatcg 3550081 atttcgtctt cttttgtggc gcggccggca cctaacagca tcgccgcgac gccgatttcg 3550141 tccgcgacga tttcagagac gacacccgct tctttggcag gcacatcaat ttgatatgcg 3550201 gcttgcggaa gcttagacgg atcgtcaaca attgagctgt cgccgccttg gtttttcagg 3550261 aaatccttga atttctcaag tgctttgccg tttttcatga cttcttccag cttcgctctc 3550321 gcttcgtcca atgtatcggc ttttttcgca agcacaacca tctggctgcc gagcgttaag 3550381 acaagctcat gaagatcctc aggcccctcg cctttgagcg tgtcgatcgc ttctttgact 3550441 tcaagcgcat ttccgatcgc aaagccgagt ggctgggaca tgtctgaaat gacagccatt 3550501 gtttgacggc cgacgttatt tccgatgcgt accatcgctt tggcaagttc agctgcgtct 3550561 tcttctgttt tcatgaaggc gcccgctccc gtttttacgt caagcacgat ggcgtccgcc 3550621 ccggcagcga tttttttgct cataatcgag cttgcaatga gcggaatgga attgaccgtt 3550681 cccgttacat cacgaagcgc gtacagtttt ttatcagccg gcgttaaatt gccgctttgg 3550741 ccgatgaccg caaccttgtc gcggttcaca agtttaataa attcatcctt cgtcagttcc 3550801 acgtggaagc ccatgattgc ctctaactta tcaatcgtgc cgcccgtatg gccgaggccg 3550861 cggccggaca tcttagcaac cggcacatca agagccgcaa caagcggagc gagaacgagc 3550921 gttgtcgtgt cgccgacgcc gccggtagag tgtttatcca ctttaattcc ttcaatggca 3550981 gaaagatcaa tcgtttcacc ggagttcacc atagccatcg tcaagtccgc gcgttcacgg 3551041 tcactcatat cctggaagaa aatcgccata gcaagcgcgc ttgcctgata atcaggaatg 3551101 cttccatctg tatagccgtt cacaaaaaat tgaatttctt cagtggtgag ttcttttccg 3551161 ttttgttttt tgatgatgat atctaccatt ctcatgtttg gtcaccgatc cttttcgatt 3551221 aagttcagta aatcaagccc acaattgctg ctgataaaaa gctgacaagc gtagcaccgt 3551281 ataataattt caagccgaaa cgagcgacga catttccttg cttttcattc agtcctttta 3551341 cggcaccggc aatgattccg attgaggaga agttcgcaaa tgacacaagg aataccgata 3551401 cgatcgctgt tgtacggccg ctgaaatgga aaccgttttg cgtaagcgac gtcatggcga 3551461 caaattcatt cgataccatt tttgttgcca taatgcttcc cgcattaaca gcttcattcc 3551521 atgggatacc gacaagaaaa gcgaatggag caaacacata tccaagaatg ccttggaacg 3551581 aaataccgaa tactgcatta aaaatgccat tgatcaatgc aataatcgcg acaaatccaa 3551641 tcagcatcgc agcgacgaca accgctactt tgaaaccgtc aagaatgtat tctccgagca 3551701 cttcgaagaa ggattgtttt tcttcttcct caacacgaag catatcctct tcttttgcaa 3551761 cctcgtacgg attgataata gaagcgataa tgaaaccgcc aaataagttc aaaacaagcg 3551821 ctgttacaac atattccggt ttcagcattg tcatatacgc accgacaatc gacattgata 3551881 cagttgacat cgcagatgcg caaagcgtgt acaagcgctg ctgatttaaa agaccgagtt 3551941 ctttcttcaa ggagataaat acttctgact gccctaaaat cgcagaagcc actgcgttat 3552001 acgattccaa tcttcccata ccgtttacct tgctgagggc aaggccgata tatctaatga 3552061 taaacgggag gactttccac ttttgcagaa tcccgatcag agcggaaata aacacgattg 3552121 gcaagagaac attcataaag aatgtcgttt ggtccgcatt caccaagccg ccaaacacaa 3552181 agttaattcc ctctgccgcg tattcaagca ggtaaccgaa tccttttgca aatcctccca 3552241 cgaggaaatt ccctattccg gtattgagga gaatgtagcc aagaataaat tgcaaaatga 3552301 gcataacaac aattgggcgg atcttaattc tttttttgcc gctgctcgcg atccacgcga 3552361 ggcctaaaaa cacgattaaa ccgataatcc caatcaaata cttcatatgt gtttctcctt 3552421 tatttgtatt cgcttacaat tactgtttcc tcagaaaacg gaaagcagtc tgccttccgt 3552481 cagctcttaa tagttgtctc cgcctgatgc attttctcct tttacgatag aaacgcctgc 3552541 gctggcgcca attcggcttg ctccggcctc taccattgtg tctacatctt ctttcgttct 3552601 gacgccgcca gatgctttca cgccgatatc aggccctact gttttgcgca ttaaggcgat 3552661 atcttccttc gttgcgccgc ctgtagaaaa gcctgttgat gtttttacga aatccgctcc 3552721 cgcagacacc gctaaacggc atgcacgttc tttttcttca tcagtcagaa ggcacgtttc 3552781 gataatgact ttgacaagcg cttttccggc tacagcttcc actacaccgc ggatatcagc 3552841 ttccaccaca tcgtcttcct tgtcttttaa agcggcaata ttaatgacca tatccacttc 3552901 agtggcgcct tttgaaatgg cgtcttttgt ttcgaacgct tttgtttcag ttgtattggc 3552961 accgagcggg aagccgatga ccgtacaaac gtcgactcca gttcccttaa gctcttttgc 3553021 agcaagctcc acccatgtcg gattgacaca tactgaagca aatttgtatg ttttcgcttc 3553081 ttcaattagt tttagaatgt ccgctttttg tgtatgcggt ttcaaagctg tatgatcaat 3553141 tatgttggct aatgacatcc ttcgcacact tccttttttg ttaagatatt ttttagcata 3553201 accgactttt gaacatatgt aaattggtaa ttgaaatttt gttcaatgaa aggtttgaac 3553261 gtgtcacaaa tcattaacaa gcgccctcgc ggtatgctgg tcaatgatta aaacgttggc 3553321 atattttccg gttaatgctc cgtgaatgga agatactttt ctgcttccgc cggcaactaa 3553381 aatggagcgt tccttcagtc taaggtcttg aagctcaaca ccgatggtcc ggtcattgat 3553441 ggcgctgctg caaatattcc ctttcgcatc aaaaaagcgt gaacaaatat ccccgacggc 3553501 ctgttttttc agcagggctt tctcttcttc gttaaaatat ccgagccgaa acaacagcgc 3553561 ttcatcacgg acagtcccga ccgtaaagag agcgatattc gcctgcttgc ccatctcaat 3553621 gatccgttca atatgacggt ctttctccac cattcgcttc acatccgcat tatcaaacac 3553681 gacgggaagc gggagatagc gcggcatcgt ttgaaaagcc tctgcaaaca gctgaatcgt 3553741 ttcagccgaa tacgtgttta cccgggaatg gctgatgccg cctttcagct ggacgacctc 3553801 gacgcctttt acctgcttcg gctgcatgtt ttgcgcgatt tgatacatgg tggttcccca 3553861 gctgacgccg acaatgtcgc cgtcttttac cgtttcatgc atatattctg caccatagcg 3553921 gcttaggtca tgtgtaattc ctgcataatc gggtgtcggg gaaaacacaa catgcgcctc 3553981 aaggagcccg tatttctctt caagtatgga accgagcgca tccaaatcct caaaagggtc 3554041 catgacgcga atctggacat accctttttc ctttgcatat tgcagcagcc gggaaacggt 3554101 tggccttgaa atgttgagct gctcagcaat ttgctgctga ctgtagtcag actgatagta 3554161 aagccttgcc gcttctatgc ttaattgctg tttttcccga tccattctgc acctccctgt 3554221 ggatcagtcc tgataaaact gcttttgatt tgcttttatt atacaggctg gcgccggctt 3554281 tcatccacct gatttctaag aaactgaaaa acgctctggg cgcggacctg cccagagctt 3554341 acttctccca agtcatatgc tgataaatgc ctttcataat ggcgtacatt ccatatagga 3554401 tcaggcctaa tgccaatata gacagaatca atttgccatg cggctgctgc gcgagttctg 3554461 cgagcgcgcc gtcaaagcct cttgtgtcgt cgggatcagc ggtcatggct gtcttgatga 3554521 gaaaatagcc gatagccgag aaaataatgg cccgggcgat attgcctgcg cgtcctgtgt 3554581 ttttcgtgat gcatatcatc tgtttgttca tttttgatgt atcgaattct ttcataaaag 3554641 cagcccgaac gcctttcata aattgaacaa tcgcaaatac gataaaaccc gcacccgtaa 3554701 gccctgtgag ccattggccg aacggctgcg ccaatacata agcggaccac gtctgttctg 3554761 aagtgccgcc gtccccttgg ccaaacacaa atcgcaaggc attccaagcg atggatgtgt 3554821 aaacagcggc actgaaaaag tttcctattc tccgcgacag gcctcgcctg ctgtttccgt 3554881 gcccctccgt gtccttgatc gcgcttaaca ccatccagat cacatagccg ataaggccga 3554941 tgcctataaa aaaaagcaat agtgacccat acggcatgcg tgatagcgtt tggagagctc 3555001 cgctcgaatc tttggcgcgg cctgccccgg cagccgtcat aaaagccaaa accccaagca 3555061 gaataaaaac gccgccgaat gcaaaataac caagcctccc gaatcgtttg atccaaggct 3555121 tggtttcctg ttttattttt gacatgtacc ggtctttcac cgccatgtgt ccaaccctct 3555181 ttcacagaaa tctttactgt aacattcccg attgaacaaa gttgaaacag ctcctgcctc 3555241 agctatggct ggctgagata cgtttttgct gtttagctga ttgtgcaggt gtcatccaag 3555301 cagccgctgc ggcagctgtg actccgcctg ctaatttccc aatgatcatg gccgccgcca 3555361 tttctttttt cattccagct acaaaaccga gatggctgcc gagtacaaag gcgccgctga 3555421 ccgcaaacgc gacattgatg acctttcctc tcggcgtcat atcctttaat gaagccagca 3555481 ttgggatatg atgcgccaaa gaggtcacta agcctgctgt tgctgtctca tctaaatgaa 3555541 ggcatttccc cagagcctga agcggttttt taaaggtttt tgtaataaat gccgtcatcg 3555601 ggaacgcccc tgccagagca atggcgatgg tccctgtcgt ttgtatccct gtctcgacat 3555661 tctccattcc cggaatcagc acaatgccgg tcatcgtttc aacagaaaca gctgcaagcc 3555721 cgataatcgc aaccatactg accgctttcc cgaagagatg aaacaactga atcattctgt 3555781 cggtgtatcg ccataaccca aaagcgatga cagcagataa cagactcggg atcagaagat 3555841 ttttacctat catgccgatg tcaaagcctg cgcataatcc gccgattaag caaccgatcg 3555901 gcactgtgca cagcccgatt aatatgcctt tcgcaaaata cggatgatcc tctttttcga 3555961 tgatgccaag agcgacggga atcgtgaaga cgattgccgg ccccatcatt gttcctaaaa 3556021 acacccatga aaacagcccg gcctgcggat ctttcgccat ttctccagcc agcgcatatc 3556081 ctcccatatc aatcgccaaa atggtgttcg caaaggaaga aggatccgcg ccaatcgctg 3556141 tgtaaaacgg agcaacaatg ggaatcaaga ttgctgccag cacgggcgcc agcgatacaa 3556201 ttccgatcat ggacagcgcc agcggcccca tagccttaaa gccgtccgca aaccgctcgc 3556261 ctagccccca tctgtttccc aaacaataat ccgctgctcc ccatagtaaa aaggcagcca 3556321 aaatgaatac aaccgcgtca ttcaccgtca tggttttctc ctttttcaaa cgtatgattg 3556381 gttttatcat atcatctgaa atcaccgaat agagttgatc ttattcaata tgagctaaaa 3556441 attcttttat atcggctttt tcaacggctg ttataatgcg tcgcgctttt tcttgcggga 3556501 ccgttaatgt caatttttct attatgtctt cttcagacag ctcatttcct ggtgcccctt 3556561 ttgggcagtc cacacgcgct tcgcaaatcc ggccgtctga taaataggcc cggacaatcg 3556621 tgaaacggcc ttttggaacg gcatgaggag ccggctgaat agcattgtca tatacgcgct 3556681 gaattcgccc cattgtcgtt tgaaccccgt ttgggatcgg ctggctgctg aaatgttcaa 3556741 cggtcaggcc gtgtccatgc aaagcaagag caatcacata ttcaacgctg aaacggcctt 3556801 cctctccagc ttttggagat ctttccgtca atgcagcatc tccgcctggc ggaaatatca 3556861 cttcaatacg ttcggtattg gcagcagaaa tggtttcttc ggagataagc tgtcgtaccg 3556921 catctgcagc atggtgtgcc gcggaacaaa atggatagat tttaaaccat agacccggct 3556981 gcacaattct ccacggtgcc ccccaatcgt ttagcaaagt gtgttgtgct ttctcaacgt 3557041 caccgtacag actgaagaaa ccagtttctc catcaagtgc cgtgcgggac ccgccaaatt 3557101 ctgattgggc cagcttaacg gccagcaagc cagcctgagc cgccaaaccg gcgtgcagcg 3557161 gtttcatttc tgttccaaat tgcaccctca tcccagcaga ttgcgtagcc gcaaaaccaa 3557221 ttgctttttc caactcttcc tgagtcagct cctcagcata acctacggcg caggcagcag 3557281 cgatggcacc aagcgtacct gtattatgcc agcccttctc atagtggcgg ctgccaattg 3557341 attctcccag ccgtgccatc acttcaacac caacaacata agcgccaaga agccgctcgt 3557401 catgtccgcg agcggcagaa gcaataaggg ccggtacgat gactgcactg gggtgtcctc 3557461 ttacatcgga gtggacatca tcaaaatcca atgcatgggc gataaatcca ttgagcatcg 3557521 cggattgtaa tggcgcggcc tttttgccct gtccgataac aggaacaagg ggccggcctc 3557581 cttcatcctc tatcagacgg aggagctttt gaattccttt atcttctctt cctgcgaatg 3557641 aagcggcagt aaaatcaagt aatccctttt ttgcttcgtg aatcgcgtca actgaatgct 3557701 caggttgtga cgttctcaca gcctctgcaa gacctgctgt cagcccttgt ttgctcattt 3557761 gatggtctcc aatacaataa ccgccagctc cgcaaagtat tgagaggcaa ccgtaagggc 3557821 ttcttcatcc agtgtaaagg ccggatgatg ccactcctcc gtcccgttcg ttcccatcca 3557881 gacaaaaaat cccggaatct tctcttgata cagagcgaag tcttctccgc ccggagactg 3557941 ctcagcgtga acggtttgat agccaagccg tgccgcagct tcggatgccg cattcaaaaa 3558001 tgtgccgtca ttctgaacgg aaggcaaata aggaaaccac ttgaattctg cttgtgcccc 3558061 atagcccgct gcaattcctt cagccactcg tctcatatgc tcgggaacag cctgcctcgc 3558121 ttctttttga aaggttcgaa ccgtcccctc catttcagct tggtctggaa ttacgttcca 3558181 cgaggtgccc gcctgtactc ttgtgatact gacgactgcg ttttgcagtg agctgatatt 3558241 gcggctgacc acagattgca gcccgctgat gatttgtccg gctgcagcga ttggatcaat 3558301 actgttattt gggatgccgg cgtgcccgcc tttccctttg atgacgatct caaatcggtc 3558361 aacacttgcc atgagcggac cttcctttac accaatggtc ccgacaggca gatccggctt 3558421 attgtgcatg ccgaaaatcg cagaaacgcc attaagtacg ccagcttcta gaacctttct 3558481 tgctcctgcg gcaatttctt cggccggctg aaagataaag cggactgtac ctttcagctc 3558541 ggcccttctt tgattcagca acatcgctgt gccaataata gaagcagtat gaaaatcgtg 3558601 tccgcacgca tgcattgtgc catcaacctt agatgcaaat ggaagattcg tctgttcttg 3558661 gatcgggagc gcgtcaatgt ccgctcgtat tgctatcacg gggccgtctt cccgtccttt 3558721 gatttctgca atcacaccag tcttcaattg agggacatca agtatttcga tttgctcctc 3558781 ctcaagccaa cggcggattt ttttcgtcgt ttcaacctct tgaaatgaca gttcaggatg 3558841 ttcatgaaga tcacgccgca tattgattaa acgggtatga aacgctttgt cggccattgt 3558901 tcttctcccc ttcttatata agctctgcag gctctcccac ctgcttgata aatcgtttcg 3558961 tccgttcgtt tttcggatgg tcaaacagtt cctctggcgt tccctgctcg ataatatggc 3559021 cgtctgccat aaaaatcact tgatcagcaa cctcttttgc aaacgccatt tcgtgtgtaa 3559081 caatgatcat cgttgtttgt ttttccgcaa tggacttgat gacctgaagc acccctgtga 3559141 cgagctcagg gtcaagcgct gacgttggtt catccagcaa aatcgcatgc ggattgaccg 3559201 caagcgcccg cgcaatgccg attcgctgct gctggccgcc ggacattgtg attggatagc 3559261 tgtcagcctt atgctccaga ccgacttgtt tcagaatctc cattccaata cgtttcgctt 3559321 cgtcgcgtgg tttatgttga gccacgatta aagcttctgt aatgttttgc agagccgttt 3559381 tatttttaaa cagattgtag ttttgaaaga ccatggccgt ttgctggcga agccgatgtg 3559441 cttccttgcg tgtaaacttt tccgcattca gtttggcttc tccgatttca ataaggcctt 3559501 gatccggacg ctctaataga tttaagcacc ggagaagcgt tgattttccg gaaccggacg 3559561 gaccgatgat tgccaccact tctccgcgtt tcacttctag atcgattccg tcgagcacga 3559621 cgagatcttt aaacgctttg cgaatatttt ttactgttat caactgattt cacctctaag 3559681 tccggtatgg cttgctcatg gcacgttcaa acaagtcctg caaaatgctg tagataatgg 3559741 taagaaccca atagacgatc gcaaccgcca aatacgtctc aaaatatttg aggtttcctg 3559801 aagcgtacat cttcccttgg gcgaacatct ccatgacccc taatgtaaag gccagtgacg 3559861 tttctttcag gagcccgata aatgtattgc ccgttgccgg aatcgcattt cggatcgctt 3559921 gcggcaaaat aatccgtctg tatgcctgaa attttgtcat accgacagac aggcacgcct 3559981 ccagctgccc gtcatcaaca gaattgaggg cggcccggaa gatttctgcc aaataagctg 3560041 cgttttttaa gcttaacccg atgatggcag ctgtgagagc tgtcattttg ctcatctctg 3560101 gaaatagctg cggcagcccg taatagatta agaacagctg tacaagtgtc ggcacgcctc 3560161 ggaaaaagga tatatacagc tttgacagct gatgaagcac tggaattttg ttttttgtaa 3560221 tgagtgcgag aataagtcct ccgataatgg caaaaatcat agctgctatt gccataaaca 3560281 aggtgatcgg aagggcctga attaaagtcg ggaacgctga tatcatgaat tcccaatcaa 3560341 tcgtgttcat tctggtgagt caccgccgtt tcttaatgct tctgttctac tgtgatatct 3560401 tcattaaagt atttttcaga gagttttttc agtgttccgt ctttacgcaa ttcatctagg 3560461 gccttattga cttttttgcg gagcttgtcg tgcgcatcgt ccttggcaaa tgggaatgca 3560521 acctgttcgt aaacaatcgg atctcctgca agctttaatg gcaaaccggt cttcttgatt 3560581 tgcgcgatca atacagttcg gctgttgaca taagcgtcta cacggccgta cgcaacatcc 3560641 ttcagcgtac cctcttgtgt ttcgtacgtt ttgatattga tttttttatc aggatctttg 3560701 ctttcaaggt ttttcgcgtg gtttgaaccg agaacggctg cgactgtctt gccttttaaa 3560761 tcgtctactg atttgatgtc tgtattgtct tttttgacga caatctgtgt tcccgcataa 3560821 gcgtatggtt tcgtaaagtt atacgtttcc ttacgttcgt ctgtcacagc tacctggttg 3560881 gaaatggtgt caagcttgcc tgtttgaagc tctcccatca gcccgctgaa ttcaagcagc 3560941 ttccagtcca gtttcatgtc aattttctta gcgactgctt ccatcacttc cacgtcaaag 3561001 cctgtcagct ttccgttttc tttataagca aatgggtaac tttgtcctgt cgcaccgaca 3561061 tgaagcacat tgtcatcctc tttactgctg ctgtttccat tgccgcaagc tgagagcacc 3561121 gctaataatg cagcaacgac cagcactgtc cattttttca tcttcatttg attttcccgc 3561181 cttttctatt tttatagatc atgtcgcaat tgttttttca tatagactgt gatatgccct 3561241 tttccaaggt cttgttcacc tgagcggaca tatccttttc gttcgtacat ctcaatcagc 3561301 cacggatgct tatccgctgt tccgagtgag acaaacggaa cctttaacgt atcgcgaagg 3561361 attgtttcct ccagccattg aagcagcttt gttccgattc cttttttacc ggtgtcgggg 3561421 tccacagcaa accaccagat atgcggaacg ccatacggtc ccggctgttt tccccaaggc 3561481 attctcaagg tgatggtcgc gatgatccgc ccgtcttctt ccatgacgta gcaagcattt 3561541 tcccgaatat ttttcagcac caaatccaaa tccgcatgag cagcagcaaa acgaatgccg 3561601 agctttcgaa tcggttcata agcccgcaat gtcagctcga gaagctgttc ggcatcacgt 3561661 tcaactgcaa ggcggtatcg tggcttcatc tagcgttcct ccttactttg catagcggtt 3561721 taccggcttt tccaaaccga agtgctctcg taatgttgtg ccttcatatt cttttctgaa 3561781 cacgccgcgc tcctgtaaaa tcggaaccac ttgatcaaca aacacttcaa ttccttctgg 3561841 aagaagcgga ggcatgatgt taaacccgtc acacgctttc gtatccaccc attcctgcat 3561901 cttgtcggcg agctgctccg gcgtgccgac gaagatatgg tggcctctgg agcctgcaac 3561961 gtatttgtaa agctctcgta tcgtcatatt gtcacgttca gccatctcct gaacaagctt 3562021 gaagcggctc ttcaccgcat tggaagcttc ggcgtcaagc ttcggcagcg gcccatcaag 3562081 cggatatgcc gacaaatcaa ttccgcctaa gtaattttgg agaatttgca gaccgacaga 3562141 tgggataatc agatcttgga gctccttgta tttggcttgc gctgcttctt ctgtatcggc 3562201 aatgattggg aaaatacccg gcataatggc aattttttct ggatcacgtc cgaattccgc 3562261 agcctgttct ttaatggatt gataaaattc ttgagctgat tccaggtggt tttgtgctgt 3562321 gaagatcact tcggctgttt tggcagccag cgcttttccg tctcctgatg atcctgcctg 3562381 gataatgacc ggctggccct gcggggttct tgaaacgttt agaggtccgc gaaccgagaa 3562441 atattctcct ttgtggttca gctcatgcat tttttctttg tcaaagaatt cacccgtttc 3562501 tttattacgg ataaaggcgt cctcttccca tgaatcccaa agccccttta caatctcgac 3562561 aaattcctct gcccgctgat agcgcaaatg gtgttcaagg tgcttttcac cgctgaaatt 3562621 cagcgctgtt gattcaatag atgaagtgac gacgttccat ccggcacggc cattggacag 3562681 atgatccaat gacgcaaact gtctggcaat atggaatggc tcgctgtatg tagtggaggc 3562741 tgttgctgtc agtccgattt ttgatgtgac ctgcgccaaa gcagagagca gggtgaatgg 3562801 ctcaaacctt gttaatacat ttggatgtga tttgctgtca attgaaaggc tgtccgctaa 3562861 aaacagcata tccagcttgc ctcgctccgc tgttttcgca agctctttaa aataatccaa 3562921 attcatgctc gcatctgacg gcgcgtccgg gtgccgccaa gacgcaacat gatggcctgt 3562981 acctgctaaa aataccccta atttgatttg tttctttttg cttgtcatgg cgatactcct 3563041 tttatcatgt ttttaggctg aataatccga aaaataaact cctatattcc tagtcgttta 3563101 atatgaataa atcaaaatgt acctttgtct tggacgtttg tcaatgagtt aagattaatt 3563161 ttttctattc aagcgaaaag acccttgcgt gaccatgagg gaacggcatt gattcattca 3563221 actagtgcaa cctctatatc ggcaagaaaa ctgagtctaa tgaagcaaag actcagtttt 3563281 cttccaataa tttcatataa gatttcgcca tttcctttgc cttttcttcg cttttgcaaa 3563341 ccgcctatcc attcagacgc cgtaacgatt gtataaaaaa acagctgact ccagatattc 3563401 aaaccggaat cagctgattg atgtgaatta attaagctca tgaatactct cttctgcttt 3563461 agcggaaaac actttaggct ccaaacagtc aaggtcttca tgaaataaat ttactttttg 3563521 gatttgccga ttgtcatagt ggtggaaata gtagtttcca gtttcgttgc acatcacgga 3563581 agtatattgc gtataatgaa tttcgtcttc ttccgttatc actgcgccct ttggtatcgt 3563641 catatttgcc aaaatttgaa aagcggctgt tacacctttc gtttcatcgg ccgccggctc 3563701 tagatgttct ttcaaataaa cagctctgac aaaccgggaa ggcggtgtat aatcccccgg 3563761 cagaccaaca gttcctaagc cttggccaaa agcagaaagg gctaatccgc ccatctcttt 3563821 gctctctaat tgcttcggtc tgattcctgt atattgctgc agattggtta catgccatat 3563881 aaagtcgggg ctgttcgtca tgacaccagg ttgattatca tagactttga ggccgtctgc 3563941 tcttggttct atcgtcaggt ttcggcccgt ccggtctgac aatatccagt gaagcggtaa 3564001 aactgtatcc aatagatcta attttttctc tacaatcgtt aaagatcgaa tcttttcttt 3564061 tacgtcttcc aaagactgac agactgacag cacccatgtc acaaactcat gcgggacaat 3564121 gtgaacggta tcttcccgta tcgttttttc gtactccgca tagcccggaa aataaagcgc 3564181 cgcacaagat aaaccgcttt cattaatgcc gtcggcaaat aatatatttc caagttttct 3564241 ccccataccg ataaacgcgt actgtgtctg atgggccctt ccgtcagctt cactgttcca 3564301 gctgtaacgg cgcggataga gaatcacctc tgtccccagc tgaaatgcaa aatccattgt 3564361 tcttgctaat acatgtttac ggtcagcagt ttccaatgta agacttgtgc acatttgatc 3564421 agtccccttt tcaattcaga ttaatatcat acatattgtg aacgaattgg ttttatcagc 3564481 ataacgaaag tcaaatcgat tcgtcaaaga attgacatta catcaaataa aacgaaaaaa 3564541 tccagccttt agaaggctgg attttttatt atttagccaa aacaagctcg tgaatcgcat 3564601 gtgcaacgcc atgttcatta ttggagcgtg tttgaaagtt tgctgcttcc aatacttctg 3564661 ggatggcgtt tgccatggca accccgcagc ccgcccattc gatcattgtc aggtcgttcc 3564721 cgttgtcgcc tatgcacatg acttccgcct gttcaattcc aagcagctga gccagctggc 3564781 gtacagcatt tcctttgctg gcttccgagt gcagaatttc ataaaagaaa ggcgcgcttc 3564841 tgaccattgt atatttttct ctcacgtctt ttggaatcga tgtaatgacg cggcttaagt 3564901 tctccggttt atcaataaac atcactttcg ggatgaggat atcttttggc acctcgtcaa 3564961 tcttgcggaa atgaagcggc acctgtgtca cataggattc gtatacggta aattcgctaa 3565021 tatcccggtt aggcgtatac aaattagatg agtcaaagaa atgcatcggc gtcttcagct 3565081 ctaagctcag gtcatataat gaagtcaaat catcataacc gagagacagc tctgagacca 3565141 cttcatttgt atgcgtattt tgaacaagtg ctccattata cgcaataaca tagtcgcctt 3565201 cttcaattaa attcagttca tctaaatatc tctgcacacc cccgataggc cggccggtgc 3565261 aaagcacaat tttgacacct tccgcttttg ccgcgtgaag ggcgtcgcgg acctcctctg 3565321 ttacttcatg atgatcattt aaaagtgttc catccatatc aattgcaatt agtttgtaca 3565381 tcctgcatct ccttcatgtc gttttcaggc tatagtccca tcatatcgtt ttttcttttt 3565441 gatattcaac cggaagagat ggttttctcc ggattctgtt tagacgccgc ccttgtcttc 3565501 ggatacgcaa gcgcggtttc cgctttcttt ctgccttgac gccgttttct gcttttttct 3565561 gtttcatcag cagaaagccg gcagctagaa aaggaatgcc ggttatattc aagatggcaa 3565621 gcttcacacc cgccgcgatg aaaaagaacc cccatgaaga tgatggattc cgtctgatca 3565681 tgacgtaagc cgccatttcc agaacgatca ggatggcatg aagcactatg ccataaatca 3565741 gcaatacaag ggcaaaaaac aaaacataat tcacgattgc ccctgagtac atcatagcgc 3565801 gcatcatttg tataaacgat aaggactgca tggagccgct gatgacatta gggttataga 3565861 tcgtatagtc actaaataaa tgtttgactt tgagaaaagc ccataatata aatatccatt 3565921 gaatgatatg taaaacaagc cccgctgcca ccagtctttc agctttttga tttctcatct 3565981 ttctcctccc tgccggtctt tgattcgatt cttgtcatcg tttttctctg tccattttgc 3566041 tcccatatca atgtcccgtt ttctcctctt ttcagcgtgc ttttgagcgg ataataaggg 3566101 ccgaggtact gaatctcgat agacccgtca gtgctttggg aaatcacctt gtatgccata 3566161 aaaggcagct gtacctctcc tcttccttcc atcacttccg tttccacaac ctcgtcttcg 3566221 gtaaatgtga ctgttgctga tttcacaccg tccgttggcc cgggggcacg cccctcatcc 3566281 cacgttccgt aataaaacgg cgtctcttct ttttgctgct ggcagcccga taccatgatg 3566341 catacagcaa ttaaaaacaa aatgccatat ttgtttctca aggggatcac cattctttcc 3566401 tccttttttg ggcgaatgcc gtgccactgt gccaatgact acataagtta taaggaattc 3566461 acccacaagg agactgatca catgaaccct tatcaatatt acagccctca gctgcctcag 3566521 caggaacctt actatagcca ctatgagtac aatccttatc cgcagcagga tgtatacgat 3566581 ccataccaaa tggacagaca gccggcattg gaaagaagaa tcgcagcact tgaacggcaa 3566641 aatgaacagc agtcaagaga attaacccgt ctgacaaacg aagaccgccg tcaaaatcgg 3566701 gaaattgcac ggattgccga acaggtcaat cagttaagcc aggctgttga acgccataca 3566761 cgccgcctaa atcggctcaa tcagcgcctc cgtacagtag aaaaccggct gaatatccca 3566821 tttactgcag gggaaggcgg tttctgagcg aaacaaagaa aaaaagcgga atacgattct 3566881 cccatctcag ggtttcgttt tccgcatttc ttatatgtta aaacggaaca tttacataaa 3566941 aagggtttgt acccagtata caatctttac cgttttcatt caaagataga ggggctgagg 3567001 aaaataattg tagttcctct ttgacggaat ttcttttcat tcaagttgca tgataatacc 3567061 gactcacgtc aatcgataca tggagggatc attcatgcat aatacacaac acggcttgca 3567121 gcagctgaac caatgccgcc aaactgctca gcagctcatt cagcaaacac agcaaagcag 3567181 ccagcaatat cgccaaatgc ttcatcagga acagcaaaac atccaaatgc tgcagcagat 3567241 tctaaaccac gaacaacaag ctgcacatac cattcagcaa gcactgcacg ggcatgacat 3567301 ggcgattcaa aagtgccagc aggttgtcaa catgtgcaac caaatgcaac aggaacttac 3567361 tggacaatcc agcgtcatga atacgaatgt gtctacactt ccattcggcc aaaacacgac 3567421 atttcagcag caatcctacc agcagtaaca tataaaaagc tcaacacaat gcgagtgttg 3567481 agcttttttt cttactgttc tttgcgaata tgtatatcct gaatagactg tttcggtgca 3567541 tgaaatctgc tctcggcttc acttcttgcc tcggcaaaag cccgcgcctc cacatgatct 3567601 ttgtagacat ccagctgaat caaatacagc gggcgcactt taaatccatg aataatggtt 3567661 accgcccata acgggaccac aataaaaaca ccgggcagat cgggcaaaac aaaaccaaac 3567721 gcaaaaatga aaaaataaat gatgccgtac atgatccact ttctatttct aaccttgatg 3567781 ccaataaata aaaaggcaaa aaaactggta atggcaaaag gcatgaaaat aaacagcatc 3567841 caccagctat gcagccattc ccaagcggca cctctttttg taattcccat atttttctcc 3567901 tcctatttac ctataataat cgattaggca caccgcgtca cccataaacg ggaaaaactt 3567961 tctcccttaa aaatagtgat agacggagaa caggtttctt gctatattat taattgataa 3568021 tgataatcat tactaatcta ttgagataca tagtgggagg gttcttgatg aaaaagaaca 3568081 tattgctcgt gggcatgctt gtgctgcttc tcatgtttgt cagcgcttgc agcggcacgg 3568141 cttctaaagg gagctcaagc gattctgctt ccgaaaaaac agaaatgaga acatacaaat 3568201 caccaaaagg gaacgtcaac attcctgcac atccgaaacg catcgtcact gatttttatg 3568261 ccggtgaatt gctgtctgtc ggggccaatg tggtcggctc aggctcatgg tcatttgata 3568321 atccgttttt aaaatcaaag ctgaaaaatg tgaaggatgt tggtgatcca ataagcgttg 3568381 aaaaagtgat ggagcttcag cctgacttaa ttgttgtcat gaatgaagag aatgttgata 3568441 aattaaagaa aatcgctccg actgttgtca taccttataa cacagcgaaa aacgtagaag 3568501 acacagtcag catgttcgga gatatcgccg gagcgaaaga ccaagcaaaa tcctttatgg 3568561 ctgactttaa caaaaaagcg gaagcagcta agaagaaaat tgccggcgtc atcgacaaag 3568621 atgcaacctt cggcatttat gaaaacacag acaagggcga attctgggtg ttcaatgaca 3568681 atggcggacg cggcggccaa gctgtataca atgcacttgg gttaaaagcg cctgaaaaaa 3568741 ttgagcaaga tgtcatcaaa aaaggagaga tgaaacagct ctctcaagag gttattcctg 3568801 agtatgccgc agattatatg ttcattacgg attacaaccc gaaaggcgaa agcaaaacac 3568861 tcgacaagct ggagaattcc tccatttgga aaaatcttga cgctgttaaa cataatcgcg 3568921 tgtttatcaa tgactttgac tcgttctacc cgtacgaccc gatttctgtc agcaaacagg 3568981 tggatatcat caccgacatg ctgatcaaac gggccgaaga aaataaaaaa taaaaaaacg 3569041 gcacagtcat gacgctgtgc cgttttttat gattcacttt aattttgact gtacggagtc 3569101 cggcatatct tcaaacttga cttcttccca agtctcgaca tactttcctt tcgccttcac 3569161 cttcaaatac gcgttcttcc gaagctcttt gccggcgaaa aaggtcactt cttctttttt 3569221 cccggatgca ttatatccgt ctaatgtata ttcagtaccg cccggactaa gatgtctgcc 3569281 atctcgatca atctgaacat agacatcttg ctggtgaata aacggattaa atctgtctgt 3569341 aacatcgtta tgaaaaaaga gaagcccgca tattacggca gcagccgcca agacggccag 3569401 gattgccatt gcttttttca tctttgcact ccccttactt gttcattttt ttcaaatagc 3569461 ttgaccgcac cgcgaggaag aatagaagct gaaaaatgaa aaaccctccg atggtgagac 3569521 tgagcggccc cgctacatcg gaatatcctt ccacagccaa tgttctcaag gcaaacagtg 3569581 tatgcatgac ggcaatgaca aatggaaaga agaaaagaat cgccaattgt attgtcacgc 3569641 tttgcgccat ttctcgctca ctcaggccga ttttggccag tgaacggtag cgctcccggt 3569701 cttcatctaa atcagtgaac agcctgaaat ataagaaact tgctgccgcg acaaagaata 3569761 caattgcgat aaacaggccg ataaatagac tcaggctcgg cagctgcacc gtatcatagt 3569821 aagtccccgc ttttgaagca aaatcagaat gcacgtcgat ataattgccg taaatctcat 3569881 tttgcaagga ttggctgatc tcaagactgt ctttccaatg atcatagctg tagccgtata 3569941 atgacgcttt atcaccgagt gatttcagct gatcaaaggt ttgatcattc accgcgatga 3570001 tagcattcaa tgagatcagc ggttttttga cttcttttac cgacagtttt tgatcagaca 3570061 gctccccttt ttggttcagc agcttcagct gatccggcgc ttcgtttttg aaattgcggt 3570121 catacgttcc cgggaaatag acagcctcgt cttctttcag gccgttcact ttgacatgga 3570181 agtattttgc cgcatccgat tcactgatca tgtaaacagg gggaacagtt tctccttcct 3570241 gatagcgaac ataggaaaca tctattttgt ctttcgtata cgtaaaaccg tgtgttttca 3570301 gttcatggtc aatatctttc aaatgagtct gttcttttgg attgttgctg taagataaat 3570361 actccatttc ataagcggac tcttccgctc cgacggtcga tttgtacatt gcgagcacgc 3570421 ctgtcgcagt aaacgcaacc gcggaaataa tgctgacaat aaagaacagg cgggcgttgt 3570481 cttttagacg atagacaagg tcagaaaccc aaatgatgtt tttcccgcgc agataaaagg 3570541 ttttccactt cttcagcgcg cgcagaatcc atatgctgct ttggctgaaa aagaaatatg 3570601 ttccgataac ggtgagcagt aaaatgataa acggttcggc cccgtggaca ttgcctttaa 3570661 gaaccatgcc gtacccgccg cacagacagg cgatgccgaa taaggacaga agcacggacg 3570721 gcttaggctc cggtttaacc ttgccagtgc cctttattaa tttgataacc gtatttgatc 3570781 tgacaaaaag gatcgtaaac tgcgataaaa agaaaaataa gagcagaaat ccgcaggccg 3570841 taataccgag cgctttccaa ggcatataca aaggcagcgc gtccatttct aaaatataag 3570901 cgccgaccgt aaagaacgtc tttgaaaaaa tgaatcctcc gataataccg gctgcaattg 3570961 acatgacgcc gatgatcata ttttccgcag taatgagctt tctcagctgc cccggcgtga 3571021 tgccctgcat gagcagaatg ccgaattctt tatttctcga tttcaaaaat gcattaaccg 3571081 aatacagaac aaataagaaa gaaaaaacaa agatcatcca ttccgcggcg gttaagcctt 3571141 ttttggcgat gttattcagg tagccttcct ttaatgccgg atgaaacagg aacatcgcaa 3571201 aggtaaagaa aatcaaaacg gaaaaggcgc tgcttaaaaa gaatgcaaga taggcccttt 3571261 tgtttctcgt gacgttttta taagcgaact gaagaaaggt catttgcgtt tccccccagc 3571321 atagacagca catcgagaat ttgttcataa aatacttggc ggttttcccc gcggtaaatc 3571381 tcattaaaca gttcgccgtc ttttataaag atgacgcggc ggcagtagct tgccgaaacc 3571441 ggatcgtggg tcaccatcaa agccgtgaca tgatcatccc gattcaggct ctgcaacgtt 3571501 tccatgacgt cttttgtcgc tttggaatca aggtttccag ttggttcatc ggccagaatg 3571561 agtgacggct tatgaatgac cgctcttgcg atggcggccc gctggcgctg gcctccggat 3571621 acttcaaacg tccgcttgtt aagcaggttt tcgataccga gctttgccgc gatgccgtgc 3571681 agtttttctt ccattacaga cggcgcttct ttttcaagcg ttaacggcag catgatattt 3571741 tcaccgatcg tcagcgtatc cagaaggttg aaatcctgaa acacaaatcc gagctgcttg 3571801 cggcggaaat gagcgagctt tgtccgcttc aggcgatgcg ggttttctcc gttaatcagg 3571861 atatcgcctg aatctggacg gtcaatcgtt gaaatgatat tcaaaagcgt tgtttttccg 3571921 gacccggacg gccccatcac cgccgtgaac tcgccttctt ctattgaaaa tgaaatttgc 3571981 tttaaggcct gataggacac ttgtccttta taggttttat ttatatgttt gacttcaagc 3572041 atattcgcca tgaaaatcct ccttatggtt ttattcttgt tgatctgggc tgctttcatg 3572101 tagtgccggg acgttcaaca taaaaatccc cttgacataa atccatgtta tcaaggggaa 3572161 acaaagcggg ctatgttgtt ttcttaacgc agccttacat ttttgtaaga aatgaaaatc 3572221 gaactgatgt cccttcaccg ggagacgagc tgatgtccac cgtatgattg agcttatctg 3572281 taatttcttt gacgagatgg aggccgattc ccgtagattc ttggaaacgc cgcccgtttt 3572341 cacccgtgta ataagggtca aacacccgct tgatgtcttg tgagggaatc ccgacaccgt 3572401 aatctttgac ttcaagcacc gtcctgtctt catcgcagaa gacattcagc tcaagtctgt 3572461 cactcttgcc cgctgaatac ttgaccgcat ttgtgaccac ttggccaatc gcaaatttga 3572521 gccatttggc atcggtgtaa atctgatgat catcgcaaac gttcattttc ggataaacgc 3572581 gatattgaat aaaaaatcgt ttatagcttt gaataactga ttggagaagc tcggacaggg 3572641 aaaccgcttc gattttaaaa tcccgttcaa acaggtcgag ccttgaagaa taaagaagcg 3572701 tctccagccc gaattcaatc tgccggactt cttttttgat ttgttcaaaa acgggctcat 3572761 cctcttcttg aatgattaaa ttaatgaccg acagcggcgt ctttacttgg tgcacccatt 3572821 gattcatata cgtcacccgc gcgtcaagct tggcttcggt ctcatggagc ttctggtgct 3572881 gcagccggat cagctccatc tgcttttcat acagctctga acagaacact gaagaaccga 3572941 gatacgggat atccgtccct tcctgccccg agctgagcca atgatacacg ccgcggtctt 3573001 tgtaccagcg ataggcaaga tagcccgcca aaataagaag ctgcacgccc aatatgtaaa 3573061 acaagtgaga aaaagaatga agacccgcaa accagtaata aaagaagaca aacagccctt 3573121 gaaggagaaa aagcagaatc agcactgcat gagaccggag aaacagcttc atgactgcgc 3573181 cctcagctgg tagccttcgc cccgcaccgc ttcaatagaa acaggcgcat tcagctcccg 3573241 cagttttttt ctgagccgcg tgatatacac gttaagtgta ttatcatcga tgaatatgtc 3573301 ggtgtcccac gtcttttcca tgagacggtc ccgactcgtc accttttctc cccgctcaag 3573361 cagcacttcc aaaagcttgc tttctttttt agaaagctca cttttttcat cctgaaaacg 3573421 cagttcaaac cgttccacaa agagctgaac gccggcatat tcaaccactt tctctccctg 3573481 ctttgcggcg tactccccgt acgccctccg gatctggctt ttgattttcg caagcacaat 3573541 atcataagaa aacggttttt cgatataatc gtctccccca ttttcaatcg ccatcacctg 3573601 atccatttcc ccgcttctgg cagaaataaa gatgatcggg cttgtggagt gctggcggat 3573661 ctgccggcac caataatatc cgtcatatgc cggcaaattg atatcaagca gcaccacatc 3573721 gggcttttcc cgcaaaaaga catcaagaac agctgtaaaa tccgcggcga ccactgtttg 3573781 atatccgtat ttttcaaggt aattctgcaa tagtccgcga atgtcttcac tgtcttccac 3573841 aatcatgatt ttattcaaac tgaaccactc ccgtttctta cactgctgcc atcatcataa 3573901 tcgttttggg cgtatggacg caacaccgca caaaaaaacc gccatctcgg cggtttctgg 3573961 tctctttagc cgacctgctg cttagctgct ttaccggctg atccgaactc tctcattttg 3574021 cttcgcactg tctcttccac ggcttcaatg ccgggtgtca aatagccgcg cggttcgtac 3574081 agatcgctgt tttcctgaaa catgcggcgt gtttcgtctg tccacgctac catacattcc 3574141 gtattgatat tgatcttcgc gtggccgagc gtgatggctt ttttgatctg atcctgcgga 3574201 atcccggatg ccccgtgaag aacgagggga atatcagtca tgcgggagat agcctccatt 3574261 tccttaaatc cgagattcgg ctcaccctga tatttgccgt gtacagagcc gagggcggcg 3574321 gccagcgcgt cgatattggt ttctttaacg atccgctcac attccgtgat atccgcatag 3574381 cggaccccgc cgaccagtcc gtcttccatt ccgccgaccg tgccgacttc ggcttctact 3574441 gacacgccgt gttttgcggc ataatcggtg acttcttttg tcatcgcgat attctcgtca 3574501 atcggctgat gggagccgtc aatcatcact gagctgaatc cggcatcaat ggcctgtctg 3574561 cagcgttccg cactgctgcc gtgatcgaga tgaagcacga ccggaacggt aatcgccatg 3574621 tcctctatta acgcgccgac catggcggca atcgttttaa atccgcctaa atagtcgacc 3574681 aggcgatcgg aagccgcggc gatgaccggt gattgctcct tttgcgccgc ctgcaaaatc 3574741 gccttcgtcc attgcaggcc gttgatatta aactggccaa ttgcatattg ctcccgcttt 3574801 gcatcttcaa gaagctcttt catcgataca aaagccatat tcacccctcc tttatccatt 3574861 acatgctgaa gtattttgat acgacatcca ctgttgtttt tttcgctgtt tgaatggctt 3574921 cctcagcagt cagcttatag tattcaggcc ggaagagctc aaccgaaaca acatcagaga 3574981 agccgatttc cttcagtgct gataagtggg catctaagtc aattgcccct tgtcccggcc 3575041 atacacgatc ctcatctgtt aaaaagccga ttgggaaatc ttctgtatca tcaatatgat 3575101 agatgaagat tttctttccg tccgcctgct ttaagctctc aatatttgaa cccattgcat 3575161 ggaagtgaaa actgtcaagg acaagcccga cattgtcacg gttaactgtg tttacaatct 3575221 catacgcctg ttcaaacgta ttgaccgtac attgcggatg gccgacaaac tcaagcgcga 3575281 tttttacgcc gtacggctcc gcgatatctg acagctcagt cagcacgtct acactgctct 3575341 ttttgatctc ttcttttaca atcttctgct ctgtcacaag cggaacggcc accacatatt 3575401 tcacaccgag ggttttgcat gtttccatca tgcctttaaa ttcagtgatg atctcgttgt 3575461 gacccttttc atcacggttg ttgaagaaaa cgagtgcgtt taaggcaagc ggtttgatgt 3575521 ggtgggtttg aaaatattcc gcaaggtcat ccaatgaatg atcttttaag tactccggca 3575581 gcttatccat agtacggatt tcaatataat catagccatg cttttcgcat agttctaaat 3575641 ccagtttaag gtttgagttt tccaatgttg tcgcttcatt aaaacaaagt ttcatgccag 3575701 actcccccat ctgcgtttta gatatgaagg gagttcggca ggaaggctgt cgccatatcc 3575761 cgccgaactc catgctcagc ttatgccaga cctaattctt ctttcatttt cttaagcata 3575821 aatcggcttg attcatccgc tctttcatcg acccaagcaa atacggcatt cgtcgcaatt 3575881 ccgtcgaact tcatctctct cagttttctg aaaatcgtat caaaatcaac ctcgccttgg 3575941 ccaatgtcca aatgctggtg aaccgttact ttcgcgtcag gcggattgac gatgtagcga 3576001 aggccatgag ccgctttatg attataggta tctgcaaata aaacatgtgt gaggcggtcg 3576061 ccggcttcgt caaacatggt ctcgatgtcg cctttgccgt catcatagaa gaacgtatgc 3576121 gcagtcgagt agacaagatt gatccaatcc ttgtcaagcg cgcggatcat atccatcgca 3576181 cctttgtgcg tttcgataaa atcatatgga tgggcttgaa gattgagttt aatgccttct 3576241 ttttcaaaga ctggcagaag ctcatccatg gatttgataa atttttcttc acttgttaaa 3576301 ggatcatatt ttgaaccgct gaattcgctg ttcatcaaat ccacttcaag ttcaaccgca 3576361 atttcgattg cccgtttcca gttgcgcact gctgcctggc ggcggtcttc atcgggtccc 3576421 gcccagtggt aaagaggaag aagcgatgaa agcttaacac ctgtatctct taaaaggcgc 3576481 tttaattgtt tgatctttgc tgaatcgact ttcggatatt tataaaacgg gcaaaaatcc 3576541 tcgcgcggcg ataattcgat atattcatag ccgagctctg ccgttttata gaccatttcc 3576601 tctaaagtta aatcatcacg atacatggat ggatccaatg ctaacttcat attttcactc 3576661 ctctgttttt tagttttgaa ctgttgtaaa agattgatag aattccggtt tttccttcaa 3576721 ttcaaccttt tctttttgtc cagattcctg ggcttttaca cacgcgtcag tcgtgacagc 3576781 agcaatatag ccgtcccatg ccgtcggtcc gctgacctcg cctttctttt gaatcgaatc 3576841 aataaagtct tggatttcca catcatacgc agcgacaaag cgtctctgcc aatccatcaa 3576901 aatatcagtg ctgaatctgc cttcttttct caagctgatg cttgatggct cgggaagctt 3576961 gatgatgccg tcttctccga cgatttcaca ttgaatgtca tagccgtatt tacagttcac 3577021 atagatttca gcattgatga cgataccgcc ttttgtttca atcacgacga tttgcggatc 3577081 ttttaaatgt ggaagcgcgt tttttgattt tttcggatag atgacttgaa cggactcgta 3577141 gtcatcattg acgagccagt ggagcacgtc aatttcatga acaagcgtgt cgactacagc 3577201 catatccgtt gtatagttat ctcctacagt cgggttgcgg tgcgcgcagt gaatcataag 3577261 aggctcgccg atgacatgat tatcgagcgc ttctttcagc tgtacgtaac cgctgtcata 3577321 acggcgcatg aagccgactt gaacaaggcg tttgcccact ttgatttctt cttcgacaat 3577381 gcgcatgcat ccttcagccg ttgtcgcgag cggtttttca cagaacacat atttctgggc 3577441 tttaatcgct ttcagcacgc ttgactcatg cgcaggcccc cagcttgtca ctaaaacagc 3577501 gtctacattt tcgtctgcaa gcaagctgtc atcattcgga taaaccgtcg cgtttaattg 3577561 gtattgctca acgacctttt gtgcagcttc ttgattaaca tccgttacag ctacaatttc 3577621 cgcgcctgac agcttgttcg tgatacggtt aatatgttct tttccgattg ctccagttcc 3577681 aattacgcca atacgtaaac tcattgacag ccactccttc tgttggttac atgattttgc 3577741 tttctgttcc tttctttact tggctctgag gagacccgta gagttcctct tgaatttgtt 3577801 caagcgactt gccagacgta ttcggcgcaa agagcagccc gatgatcata ctggccgtca 3577861 cacatccgag aagaattgca gccatcgttc caatgccgaa attggtgata atcattggga 3577921 caaacagact ccaaatccct attgaaatac ggacaaggaa aaacatcagt ccttgtgcgg 3577981 aagcacgata ttgcgtagga aagatttcgc tggcccataa ctgatagttc gcttgctgcc 3578041 cggctccgtt attgatgccg atcacgacaa taaacaggag cagaatcggc aggccttcaa 3578101 ctggcagcag aaacagtgtc cacccgatca ccgccatgaa agcggcgatt ccaaatacgg 3578161 tttttctata tttgtcggca aagggcatga agatcaaggc gacccccaat cctgtgaaga 3578221 taaacagccc catttgcaaa aggttggcca tgttggcaga tacaccgccg acctgctgat 3578281 aaatgtatgg cataaagaag cccatgaccc cggcggctag gttccaaacc aagtacacac 3578341 ccatcaaaaa caggatgctt tttagataca taggcttgag caaatcaaaa tacgatgtct 3578401 tattcaatac agccggcttc tctgcctgag cttcctccgg ctgatttttt gtctgccagg 3578461 cgtctgattc cggaagcctg attctcagga tgtacgtaat cagcgcaatc acaagcagat 3578521 gggcaaatac gattttattc cccaagagtc ccaagtcacc ggccagtacg gagaggagca 3578581 gtacaacgac agcgcccgcg gcccaagcga cttgtgctac gccgcaatgc ctggcccgat 3578641 tcttctttgg cgcattttcc gcaataatgg tccatgacgc ggttatgtca gcccctactg 3578701 ataaaccgat aatgatgtaa ccgcttaaca acatggggaa attaaccccg aacaaaacca 3578761 aacaaatccc tagtgcataa accagcatac tattggtata aacagccttc cgtccgactt 3578821 tatcagccag aaacccgcca agcagcgcgc cgacagcggc agaaatcgca tttgcgctca 3578881 acgcgccgag cagcccgatt tgcgtatcgg atagcttaag gtaactgacc cataatgata 3578941 aaccggcgga gcctgccaca attgaaccgg catcaatata gttggccaat gctgccgcga 3579001 ttgtccgttt attgaaggct gaatctccat tggtattgcc catatgttca ttccccatta 3579061 agccagatcc aacaactgct gatcaatata gtttctcgca atcaatgcat actccagcgg 3579121 gtttgcaaca tcggggtctt gttcagcttc aatgacaatc catccggaat aactgtgctt 3579181 caacagcagc tgatatactt ctctaaagtc aatgcagccg tcaccgggaa ccgtaaacat 3579241 gccttttaaa aatgattgcc ggaacgattg tccttcgagc ctgcattgtt ccatgacatt 3579301 caggcgggca tccttaaagt gcacatgctt aatgcggccg atatgcttct caagcatccc 3579361 catgtaatcg ccgtcagaaa tatacgcatg gcctgtatca tagaggaggt gtacatgcgc 3579421 agggtctgtt cctgccatca ggcggtccac ttcttccgct gtttggacac cagtgccgag 3579481 atgatgatga tagacaagct tcaagccatg ctgagcggca atttcgccaa ggtgattcag 3579541 cccttcgcaa agccgctccc attcatcatc cgtaaagtgc ggcttctctg tgaacacatt 3579601 tttctccaag ctttgcacgc tgtacgtttg ttcagagaca actgcgacat ccgcgtttac 3579661 ttgctgcaaa tactcacaat gcagggtaaa tgtctttgcc gcttcaccaa gtccgtcacg 3579721 caaaataaaa ctgctgaacc attttcctgc aatgcgtaag ttccgaagct tcagctcttt 3579781 gttcaggatg gcaggttcgg ggaaaaagcc cccgacctcc gtgccttgaa aacgtgcgac 3579841 aacgatatca cttaacaaat gctgaagtgt atttcccgct ccaatttcag gcatgtcatc 3579901 attccgccac ccaatgggag cgattcccca caggatttca tttttgccca tctatggtgc 3579961 ctcccctcta atactgcttc gcagattcca gctttttctc ttttgcttcg tatgctttct 3580021 gaacgctttc ttgttcagat acctctgcca ccccgacatg ccaccagctg tcatagccgt 3580081 ccgtcattgt tttaggcagc accttcattt caattaatgt tgatacatcc tgtttcttcg 3580141 catcctctaa cgcagctttt aattcttcta ctgtgtttgc acggtaggtt ttcgcgccgt 3580201 atccctcagc gactttcgcg taatcgacat tcaggatttg gttgtcatct gtgcggaact 3580261 cgcaatagta gctgccgctg ccgtgatcca tttgcaggtt gttgatgcat ccgaatcctg 3580321 agttgtcaaa gagcagcaca ttgattttct tgttgtactg aatcgccgtg atcagttcag 3580381 aatgaagcat caggaagctg ccgtctccga cgattgaata cacttctctg tcagggtggg 3580441 ccagtttaag accgagtgtc ccggacactt catagcccat gcaagaatat ccatactcca 3580501 ggtgatacgt attcggaaca ttagaatgcc acagacgctg caaatctcct gggagtgagc 3580561 ctgctgaaca gatgatgacg ctgtcttcag gaatcgtctc gttgattgtc agcaatgccg 3580621 ttgtttgcgg aagctccgta ttcaacgcgt cagcatattc attcaggacc tcttgagaaa 3580681 agtgattttt gatttccgga tcaaatgctt cccgcttaaa cgtcactttg ctgagacgct 3580741 cgcgttcagc tagccattcg tccttcagct cccggatcgt tgtgccgaac tcgctctcat 3580801 agccttcaag caagccgtgc agtttgccaa gcgtcacttt cgcatccgcc accacttgga 3580861 atgcatcaag tttatacgcc tgcattcggc tgacgttaat gttcaaaaac ttcgctttat 3580921 caaaatcaaa agcggtctta gaggatgtcg caaaatctgt ataccttgtg ccgatgccga 3580981 taatcaaatc agcttggcgg gccgctttgt ttgccgcaag tgtacctgtg atgcccattc 3581041 cgccaaggtt gttcgcaaaa tctgcctcaa cggtagactt tcctgcctgc gtttcaacta 3581101 acggaatgtt ataggcttca gaaatggcaa ccaattcatc gcgcgcaccg gaatattttg 3581161 cgcctccgcc gacgagaatc acaggttttt tgctggattt aatcagctcc gccgcacctt 3581221 gaagctcgcg ctcgctcggc tgcatgcgat caatatagtg aacccgtttg acgaagaaac 3581281 tttcatcaaa atcgtatgct tccccttcaa catcctgaga aatacaaatc gttgccggac 3581341 ctgcttttgc cggatcagtc atgacttcaa acgcgcgcag caaactgctc atcagctgct 3581401 cagggcgcgt aatgcggtcc cagtatctcg atacaggctt caatgcatcg tttgtcgtaa 3581461 tcgccgcact gtattcttgc tccatttgct gcagtacagg gtctggctgt cttgtcgcaa 3581521 atgtgtctgc cggaatcaag agaactggga tattatttgc caatgcagtg ccggctgccg 3581581 ccaccaagtt agccgctcca ggtccgacgg atgtagacac cgcatatatt tttcttctca 3581641 gcatttgctt gctgtacgcc atggccgcat gcgccattcc ttgttcattt ttcccttgat 3581701 agactttcaa atggcctgca tcctgctcaa gcgcctgccc gatccctaat acgtttccat 3581761 gaccgaaaat cgtgaagatc ccttcgacaa aaggctcttc ctttccatct acatggatgt 3581821 actgctggtt taagaattta atcagcgcct gcgcagttgt taagcgaatt ttcttaccca 3581881 caaacgatcc cacctttact cgatcttttt caattatgac tgtgcttcaa taagctgttc 3581941 gatttcttcc gcagtcggca tcgcttctga cgaactgtgc ttgctcacca caatggaggc 3582001 tgaagcactg ccgtatttca atgccgtttc aatgtctttt ccgctgacaa ggccatagat 3582061 aaaggctgac gcataggagt caccggcccc aaaggttttc agcacttttg tcttgtacgc 3582121 ttgagcgcgg aatacctcgc cggatttgct gtatgcgtaa gagccttcga cgccgtgttt 3582181 gatgacaacg aggtcggctg aatggccaaa taaatgattg acggattctt cattgcttcc 3582241 gcctgtgcgg ttttccatca catcaaattc atcgcgtgtg ccgatgacga tatcagactg 3582301 ctcggcaacc aaagaataat aaacggctgt ttcatctgat gactgccacg tatatggccg 3582361 gtaatccagt tcgaatacca ccttaacctg atgctttttc gcgtattgaa cagcttttaa 3582421 caccgcttcc cgtgacgggc ttttggcgag cgctgtcccg gagacaagca gcattttcgc 3582481 atttgcgata tagtcctcac ttacctctga aggctcaaga taaagatccg ccacatcatc 3582541 gcgatacatt aagatgctgc attcttcagg gctgaggatt tctgtaaatg caaggcctgc 3582601 tttgtgtcca tcttgatcaa caatcatctg tgtagtatcc acgccggtct ttctcatata 3582661 ggactctatg aatcttccat gctggtcatc cggaattttg ccgatgaagc ccgcttttaa 3582721 gccaagcttc gcgctgccga tcgcgatatt cgcaggtgaa ccgccgacat atttcgaaaa 3582781 tgtcatcgtt tcttccattg ggcggttgta ttcgactgcg ttcagatcaa tacatgcccg 3582841 gccgatggca acaatatcaa aagccttctc ttcattgaat gtatacttca tcgtaaacag 3582901 ccactcctca cttgttagcg ttctaaaatc cattcatgcg ccgggtcgtt ataaaacttc 3582961 cattttcgcg tcggccctgc catgacattt aaatagtagg atgtgtatcc gtccggaacg 3583021 cctaccgggt ggtatcccgc aggaacgatg acaacgtttt catttcccac agtcattgtc 3583081 tcgtcaatag aacggtcatc tgtgtatacg cgctgaaaca caaagccctg tcccgggtct 3583141 aactcatggt agtacgtttc ttctaagaaa gattcttccg gcaagttgtc ttggtcatgt 3583201 ttgtgaggcg ggtagctgga ccagttgccg ctgtctgtat agacttcaac tactaataga 3583261 ctgttagctg aagggtctga atccggaaga atgttatgaa cagtacgttt gtttgaaaat 3583321 tgcccgcgat gctcaattcc gttgtcttcc gctttgatca gctttgtcgg aagctgcttt 3583381 tccgatggag aatagcaaag cgccactctt gcgtcgctga ccgctgtgat ctcaaatgca 3583441 cggtcatttg aaatatagac gctgtctgtc ggttttcgtt caaatacgct ttcgcgcgtg 3583501 ccgatattct caaaagtcga ctcatgatct gtcactgtaa ttttccccgt taccgccaca 3583561 atacagattt cttgtttttt caattcttct gtatagcttg aacctgatgc aagatctaac 3583621 actttaaact ctacataagt gagatcagag ttggatgtcg ttacttcgtg cacgagtttg 3583681 accccattag acacttcatg cgactgcggc ttacgcaaca aataactcat agagaagccc 3583741 tcctctttct attggcagaa tgagtccgaa cagcgcacat ggacgccgtt cggctgttcg 3583801 tcgtttagtt gaaatcaggt gccggatatc ttgccgtcac cactttttta cgtgtataga 3583861 agtcgacgct gtcttttccg ttcgcatgca gcgttccaaa gaatgaagat ttccagcctg 3583921 agaatgggaa gaacgccatt ggagccggca caccaaggtt gatgcctagc attcccgcat 3583981 caatgttttc acggaagtag cggattgcgt ttgagttgga tgtgaacaag caggcgccgt 3584041 tcgcaaactc agacttattg gcgatttcaa tcgcttcttt caggtttttc acacggatga 3584101 cagataagac cggagcgaaa atttcatctt tccagatcgt catttctgtt gtgacattgt 3584161 caaagatcgt cgggccgaca aagtagccgt cgtcagacac attttcacgt ccgtcacata 3584221 cgagtctggc accttcttca agaccttttt cgatatagct gagcgtgcgc ttcttgttgt 3584281 cttcgcgaat caccggtcct aagaacacgc cgtcatcaag gccgttaccg attttaatgt 3584341 ccgccacttt ttcctgcagc ttcgccataa attcatcggc gattccttct tcaactgtca 3584401 caaccgcaca agccatgcag cgttcaccgg cagaaccgaa ggcagctcca acgatgtttg 3584461 taaccgtgtc ttcaagattc gcatcgttca agacaatcgt atggtttttc gcgccagtca 3584521 gagattgaac gcgttttaag ttttcgcttc cttttttgta gacgtattcg cctactggct 3584581 tggagcctac aaatgaaatc gctttaattt cgggatgctc gaggatgccg ttcacaacgt 3584641 catgcgcacc gtatacgacg ttgaacaccc ctttcggaag gcccgctttt tcaaaaagct 3584701 caaccaattt ctctgttaac agcggagtcc gctcagatgg ctttaaaata aatgtgttgc 3584761 cgagcgcgat cgccatcggg aacatccagc aaggaaccat catcgggaag ttgaatggcg 3584821 cgattccgcc gacaactccg attgggtaac ggtagttcgc cgcttcaacg tccgttgcga 3584881 tggaagcaag tgagtcaccc atcatcaggg aaggtgctcc agcggcgaac tctacgtttt 3584941 caatcccgcg tcccacttca cctaaagctt ctttcgtgtt ttttccgttt tcaatggtaa 3585001 ttagatgagc aagttcttct ttatgctgag acagcagctg ctggaagtta aatagaattc 3585061 tggcgcggcg aggaaccgcc acctttgacc atgttttaaa tgcttcagcc gctgtttgcg 3585121 ctgcgtaatc aatatcctct tttgtagaaa tcggcacttg gcatagcact tctttcgtcg 3585181 ccggattgac gacatcttca tattgatctg ttttgctttc aacccattca ccgttgatgt 3585241 agttttttaa ttttctgatt tctgccattc ttattgcctc cttcattagt aaacacatac 3585301 acttgtatgg atggttccgg atagattcat atcaatatcc acttttcagc aagccaagaa 3585361 ttaaacgctt tcaaaaacac caaaaaaata aatggcggat gcatatttac atacaagcaa 3585421 ccatttcatg cacaacaggt tactttttgg tcatttcttg gttatattct aatcgcataa 3585481 tacccataag tcaatcataa acactacatt ttttcattat ttttattata ttaatctttt 3585541 aatcaagtaa gagaagtaag agaaggccgt ccaatcttgc aaaagatata caccgatgtt 3585601 atcattttta agcaactatt gattaacttt tggtttttat tatatattta tgttacgtaa 3585661 agattcaaga aggagttttt tatatgaaac tgatgcggat tcaggaaatg gaggagtaca 3585721 ttttatcgca tggcactgtt tccttagatg agctgtgcca ggtgttcaat gtctccaaaa 3585781 acacagtcag acgtgatatc aacaagctaa cagaaaaggg tgcgattgaa aaagtatacg 3585841 gcggcgtaac atctattgaa aaaaccgcat tagttccttt tgaaaatcgc accattcagc 3585901 accaggatga aaaaacaaaa atcgcccatt atgcttcccg atttattgaa gatcacgatt 3585961 tggtcttcat tgattcagga acgacgacaa agtctattct tgatacgctt gatccagcca 3586021 aaaatgtcac catcttaacc aacagtttag acattatcaa tgcggcgtca gctttgaaga 3586081 atatcaactt aatcattatc ggaaacaact ataagagaaa aacccgctcc tttgtcggca 3586141 tggacgaccc ggctatgctt gataagtaca atatcaacaa agcctttatg tccgctaccg 3586201 gaacgacgct gactcacgga ttgaccaatt cggatctgct ggagtatgaa attaaaaaga 3586261 ggatttcaga aaaagcaaaa gaagtgtatc tattggctga ccattctaaa ttcggaaaat 3586321 caacgcttct gacgtatgca ccgtttgaca ggctgcattg cattgtgacc tctcagccat 3586381 tagacgacga gtacacgcag tactgcaatg agcatcaaat cggcattcat ctggcctaac 3586441 gtttacaata gtgttgagag tctatcatcc attttattct aggaggcaga tcatgaaaaa 3586501 agcgaagctc ggaaaatcag acttgcaggt attccctatc ggattaggaa caaatgctgt 3586561 cggaggacat aacctctacc cgaacctaaa tgaagaaacc ggaaaagaat tggtgcgcga 3586621 ggcgatccgt aatggcgtga caatgttaga caccgcttac atttacggga tcggccgttc 3586681 cgaagaatta attggtgaag tgctgcgtga attcaaccgt gaagatgttg tcatcgcgac 3586741 aaaagccgct cacagaaaac aaggcaatga ctttgtcttt gataattcac cagattttct 3586801 taaaaaatca gttgatgaaa gcctgaagcg cttgaatacc gattatattg atttgttcta 3586861 cattcacttc cctgacgaac atacgcctaa ggatgaagcc gttaacgcgc tgaatgagat 3586921 gaagaaagcc ggaaaaatcc gttccatcgg tgtatccaac ttctctttag agcaattgaa 3586981 agaagcaaac aaagacggtt tggtagatgt attgcaaggc gaatacaacc tgttaaaccg 3587041 tgaagcggaa aaaacattct tcccgtatac gaaggagcat aatatttcat ttatccctta 3587101 cttccctctc gtatcaggtt tattggcagg aaagtataca gaagatacaa cgttcccaga 3587161 aggcgacctg cgaaacgaac aggaacactt caagggtgag cgtttcaaag aaaatatcag 3587221 aaaggtcaac aagcttgcgc cgattgccga aaaacacaac gtggatatcc ctcacatcgt 3587281 attggcctgg tatttagcaa gaccggaaat tgatatttta atcccaggag caaaacgtgc 3587341 cgatcagctg attgataaca tcaaaacagc tgacgtgacg ctttctcaag aggatatttc 3587401 atttattgat aagctgttcg cataagaaga aaacagcctt ctccaatgga gaaggctgtt 3587461 tttttgtgcg ataaattcct aaataactga ttttgaagca aaaccttaca aaatgagcca 3587521 taaatccgat aaaataaagg tagtttatct cagaaagaaa gtgattgaga aagcaaaagt 3587581 atgaaacgtt catatcatct agctcatatg aaataaagct gacccagctt cttttatttg 3587641 ctggtcagaa tagcggaccg tttcgatggt ctatggagga aacagaatga aacttaaata 3587701 tgtaaaagcc ttagttgcag taaccgttgc tttaggtgta ctgctgccat caacgatttc 3587761 tcatgcaaag agctttagcg gccgctcatc atctagttac agcagccgaa gttcaagctc 3587821 atcatacagc ggaagctata aatcaagccc gaaatcaagc tacagctcag gatcaagctc 3587881 ttctagcaaa aaatccaaga cgtctgacga ttcatcatca tcgatttcgc ttaaaaagaa 3587941 gccttcggaa aaggcaagtt catcaagctc taaaaaatcg tcaggcacct tttccggcgc 3588001 tacatcaaaa gtaaccggaa agacatacag cggaaaaacg tctaaagcct atgttggcgg 3588061 acgttatgtt tcagtcaatc attactatca cgcaggtttc gcgccatcag gatggtttgg 3588121 atattatagc ggatttacaa tgggtatgtt catgatcagc atgatgcacc catggggtta 3588181 cacctatcat ccagtcggag gccccggtta tgtttcttat ggcgcttcac ccattgcctg 3588241 gatcgttgat atcatcgctt tgattattat tttaatcatt gtcatcgcat tgattcgcgc 3588301 atttaaagca ccgaagacgt acagaaggag attttaggca atgagattaa tattaaatga 3588361 gcaagaaatt gtagacggaa tttgcgtgta tatttccaat gaagaagata tctaccctga 3588421 agacgttgaa gtaaaagaac tatcgtacaa caagcgtaca gggttcttcg ctgaagctac 3588481 atttggcctg caccacaagc agcttatgtc agatgacatt tcagaaggca ttattcagtt 3588541 cttagaggaa taccacaact tcaatccgga cgttaccgtc gttgaattgc aatttgataa 3588601 gaaaaaaggc ttctccgcct tggtttttgt caacgaagca gaagaataaa aatgtcttaa 3588661 tcaaacctta ctccgcgcgg gtaaggtttt tttaatggtt tctctgagca taaagttatt 3588721 tcgtttttcc taaactcagc ggatctgtga tcatctcttt tggctataaa gtttccgttt 3588781 tttcaaaaca aatgtttcaa atgagatagg aaatgggtac taatctatta actttgttac 3588841 atatttttag atactcattg gctcaacaac tgaggaggag acatttgtga agaaagacac 3588901 aaggaaatat atgatctact ttttcggcgc tttaggggga ctgctatatg gttacgatac 3588961 aggtgttatc tccggagcac tcctgtttat caataacgat attcctttaa cgacattgac 3589021 agaaggattg gttgtcagca tgctgctcct tggcgcgatt ttcggttctg ccttgagcgg 3589081 cacatgctca gaccgctggg gcaggagaaa ggttgtattt gtcctttcca tcatttttat 3589141 tatcggtgcg ctcgcttgcg cattttctca aacaatcggc atgctgattg catctagggt 3589201 gatactcggg ttggccgtcg gcggttcaac ggcacttgtg cccgtgtatc tttccgaaat 3589261 ggcaccgacg aaaattcgcg ggacactcgg cacaatgaac aacttaatga ttgtcaccgg 3589321 gattttgctc gcctatatcg ttaactacct gttcacaccg tttgaagcgt ggcgctggat 3589381 ggtcggtctg gctgcagtgc ctgccgtgct tctattaatc ggcatcgcct tcatgccgga 3589441 atcgccaaga tggctcgtga agcgcggcag cgaagaagaa gcgagacgca tcatgaacat 3589501 cactcatgac cccaaagaca tcgaaatgga attggcagag atgaagcaag gggaagcgga 3589561 gaaaaaagaa acgacacttg gcgtgctgaa agccaagtgg attcgcccta tgcttctgat 3589621 tggcgtcggc cttgccattt tccagcaggc agtcggcatt aacacggtca tctactacgc 3589681 gccaaccatt tttacgaagg ccggtcttgg cacatcagct tcggcgctcg gcacaatggg 3589741 aatcggcatc ctcaacgtca tcatgtgtat cactgccatg atcttaattg accgtgtcgg 3589801 ccgcaaaaaa cttctgatct ggggaagtgt cggcatcaca ctgagccttg ctgctttatc 3589861 aggcgtgctc ctgacactgg ggctttccgc atcaacagcg tggatgacag tagtctttct 3589921 cggtgtctat atcgtctttt accaggcgac atggggtccg gtagtgtggg tgctcatgcc 3589981 tgagctcttc ccgtccaaag cacgcggagc cgcgacaggg ttcacgactt tggtgttatc 3590041 ggcggctaac ctgatcgtgt cgcttgtctt cccgctgatg ctaagcgcga tgggcatcgc 3590101 atgggtcttt atggttttct cagtcatttg tcttctctca tttttcttcg cgttctacat 3590161 ggtaccggaa accaaaggga aaagcttgga ggaaattgaa gcaagcctga aaaaacggtt 3590221 taaaaagaag aaaagcaccc aaaaccaagt gctgaatgag cgtacattat aaaaaaagga 3590281 atcgtctcct tatgagacga ttcctttttc tgtttacacc atgaccttgc aaatattgtt 3590341 cgtaaattcc acagggtcct gaatcggcag gccttcgatg aggagcgcct gattgtacag 3590401 aaggtttgtg tacaggctca gcttctcttt atcttgttca aacgcgtcct gcagtgtttg 3590461 gaatacctcg tgatttgggt tgatttccag cactttttcc gccttcacat tttggctgtc 3590521 aggcatcgca tttaagattt tttccatctc aattgtcact tcgccgtcag cagcaaggca 3590581 gactggatgt gatttaagcc gttttgagat tctgacgttt ttcactttgt ctgacagaat 3590641 gtttttcatt tcctcaaaca gatccttata cttgctttcc tcttcctcgg actgcttttg 3590701 atcctcatcc gtgtctatgc caaggtctcc gcttgatacg gacttgaatt ctttttcctg 3590761 ataagaagcc agcattttaa ttgcaaactc atcgatgtcc tcagtaaagt agaggatttc 3590821 atagcctttg tccgccacca tttccgtttg cggcagtttc tcaatgcggt cgtaagaatc 3590881 accggtcgcg taataaatga atttctgctc ctctggcatt ctggaaacat actcgtctaa 3590941 gctgaccagt tttttctctt ttgaagagta gaataagagg agatccttca attgatcctt 3591001 attcgcgcca aaatcattgt acacgccgaa tttcagctgt ctgccgaacg acttgtagaa 3591061 cgtctcgtat ttctcgcggt cttttttcaa caggctttgc agctcgcttt tgattttctt 3591121 gctgatgttt ttcgcgatca gcttcagctg gcggtcatgc tgcagcattt ctctggaaat 3591181 attcagcgac agatcctcag aatcgaccat gcccttcaca aagctgaagt ggtccggtag 3591241 caggtctgcg cacttattca tgatcagcac gccattggaa tacagctcca agcctttctc 3591301 atattccttg gaatagtagt caaacggcat gttttcaggg acgaatagaa tcgcgttgta 3591361 gcgaaccgct ccatccacgc tgatatgaac gtgtgtcagc ggtttatcaa acccgtaatg 3591421 cttttcagca tagaattttt cataatcctc atctgtcagc tcgcttttgt tttttctcca 3591481 gatcggcacc atgctgttga ccgtctgctc ttcctgcacc tcttcaaatt cattttcgct 3591541 gccttccttc ggcttattaa tggttgtatc cattttgatc gggtagcgaa tgaagtcgga 3591601 gtacttcttg atgatcgctt ttaaacgata ttcctctaaa aactcgtcat agctgtcatc 3591661 ttctgtgttc tctttgattt tcaggataat gtctgtaccg acagaatcct tttcacacgg 3591721 ctcaatcgta tagccgtctg cacccgcaga ctcccattta taagcctctt cgctgccaag 3591781 cgctttactg atgactgtca cgacatcggc aaccataaat gccgcgtaaa aaccgacacc 3591841 gaactgcccg ataatgtcat gtccgtcttt cagctcgttt tcctttttaa acgcgaggga 3591901 accgcttttt gcaattgttc caagatgctg ttcaagctca tcctttgtca ttccgatccc 3591961 cgtatcagag atggttaatg ttctcgcatc tttgtcagct gcgaccttta tgtagtaact 3592021 gtctttatca aacgtaagcg catcgtccgt aagcgctttg taatagattt tgtcaatcgc 3592081 atcactcgaa ttggagatta actcgcgcag gaaaatttct ttttgggtat aaatggagtt 3592141 aatcatcata tccagcaagc gtttagactc tgctttaaac tcttttttcg ccactcttga 3592201 tcgctccttt accattatgt aaaccctttt cagcatctat ttatcacata agatgacaat 3592261 tgtcaattag attgatagat gcatatatat gtaaatttaa cattagttgg atttgttttc 3592321 actctttttc tcactcattc tcataaaaaa gagaggcttc atcatcctct ctttttttct 3592381 gtgtcattcc aacggccaaa ctcccgcttc atccatatat gcaccgggta gaaaaacaaa 3592441 ccgaacggta tcaaaaacaa aagattatgc catgaagcat tcagaaatgc gcttgcagtc 3592501 accgggaacg taatctcttg caataaaaaa gagatgacag tcagcacaac aaatgcagat 3592561 ggaatggtca cgatgcaata aaacttgagc tccttcttat gctgtacctt caaacataca 3592621 aacctcccaa caatttctaa ttcatcttaa catatgctgg cctttctttt ctcgcatgtt 3592681 tatcactgca catagcggga agacaaatag aaaaaggagg tctcgtatca tgggaagact 3592741 tgaaaacaaa acagcagtta tcacaggcgc cgcgacaggc attggtcaag cgacggcgga 3592801 ggtttttgcc aatgaaggcg cgcgtgtgat catcggagat atcaataaag atcaaatgga 3592861 agaaacagtt gacgcaatca gaaaaaacgg aggacaggcc gaatcctttc acctcgatgt 3592921 gtcagatgaa aacagtgtga aagcatttgc tgatcaaatc aaggatgcat gcggaacgat 3592981 tgatattctg tttaataatg ccggcgttga tcaggaaggc ggaaaggtgc acgaatatcc 3593041 ggttgacctg tttgaccgca ttatcgccgt cgacctgcgc ggcacattcc tttgcagcaa 3593101 atatttgatt ccgctcatgc tcgaaaatgg aggctccatc atcaacacct cctccatgtc 3593161 aggccgtgcc gcggaccttg accgctccgg ctacaacgcc gcaaaaggcg gtatcaccaa 3593221 cctgacaaag gcaatggcaa tcgactacgc acgaaacggc atccgcgtca attccatttc 3593281 accgggcacg atcgaaacac cgctgattga caaattagca ggcacaaaag aacaggaaat 3593341 gggcgaacaa ttccgcgaag ccaacaaatg gatcacgccg ctcggacgtc ttggccagcc 3593401 caaagaaatg gcaacagtgg cactgttcct cgcatcagac gacagctcat acgtcacagg 3593461 agaagacatc accgcagacg gcggcatcat ggcgtacaca tggcctggga agatgctgat 3593521 tgaggagaaa tggaaggaag aaacgaaata agagagggag ccccctctct ttttgtcttt 3593581 taaagcaata caaccttata tttcttcaca tccaaaaact gcaaaaactc cctcgccagc 3593641 acttcaggcg gatgcgcctt tccttcatcc agccgataca aaagcaaccc gataatcatt 3593701 gcggatacat aatgggcata aagctttttc tctgcgtgaa tatcagtttg ctgatgcaga 3593761 taaaacgatt ccagcgcttt gaacatatca ggtatcacat gaggaacacc ccattcccga 3593821 ttgagaaaat ggacaatggg catgtttgac aaagcagaaa gcagaatggc gagcgccttc 3593881 tccgcttcct ttaaggaaaa ttcattcggg ctggaggcaa tcgtcaggtg atcaatgatc 3593941 tccgcacatg atcgctgtat catggtttgg agcaattcct ccttattggc atagtgatca 3594001 taaaaggttg cacggcggat attgctttta cgcgtaatat ctgaaatcgt gatgcccgcg 3594061 tagtcttgtt tctccgccaa tacatccaga aatgccttct gcagcgcctc tctcgttcga 3594121 accacccgcc tgtcgatttg cttctccttc tctcgctctc ctggcacagc ttttccaaac 3594181 agccaataaa accgcttttg agaaacaagc tcccatacct tctggctgat ggcttcagga 3594241 gacgcggccg catcctcatt cagccaatac aggataatcg cgtacgtgta caaggcccga 3594301 taatgtccat aaatgtcccg ttcaatcggc gttaaattca catggatcgg agccagcagc 3594361 acatcctgct gaaacacatc cttaaaaaaa cgatgaaaat gtcctctgtt catcatcaca 3594421 gaaaaaaagg aacgatgctc atgaacaaag gacagcgtcg gatgcaccgt ttgccgtttt 3594481 ttgttcaaat gaagggtatc catatgactg aaggcgtcaa aaagcgcttt gcccagtcct 3594541 tccttcatgt cttcgatcac atcctcaatg attgaaaact tatcctcata ataaaggtag 3594601 agcgatccgc ggctcacttt ggccttctca gcgatttctt tcattgtgat gtgttgaata 3594661 tctctatctt tcaataaagc cagcagcgcc tctttcactt gagcttcggc agattccggc 3594721 acaaaagaca cctccaatca ttagacagat cttagatata tgtacggtaa cgtatagatg 3594781 gttcaccgtt gtctttctta cagaaaaggt accaccttat aataggtccg agaaaagaag 3594841 aaagcaaatg agggggattt tacaatggaa cagcaagtaa aggacgacat ccagcgtgtc 3594901 tttcagcttc agaaaaaaca gcaaaaagcc ttgcgcgctt caacagcgga acagcggaga 3594961 gaaaagcttc aacgcttttt agattccgtc atcgcccatg aagaagaaat catcgaagcg 3595021 atccgcaaag acgtccgcaa accatatcac gaagtcaaaa aagcggaaat cgaaggaaca 3595081 aaaaaagcga ttagagataa tatgaataac ctggaacaat ggatggcgcc taaagaagtc 3595141 ggttcatcgt taagccctga cgcaaacgga attcttatgt acgagcctaa aggcgtcaca 3595201 ctcatcctcg gcccgtggaa ctatccgttt atgctgacga tggcgccgct tgccgcttct 3595261 ctcgcagccg gaaacagcgc gattgtgaag ctgtccgatt tcacgatgaa cacgagcaac 3595321 attgctgcta aagtaataag agacgctttt gatgaaaaag aagtcgcgat ttttgaagga 3595381 gaggttgagg tggcaaccga actacttgat cagccgttcg accatatttt cttcactgga 3595441 agcacaaatg tcgggaaaat tgtcatgaca gcggctgcca aacacttggc atctgtcaca 3595501 cttgagcttg gcggcaagag cccgacgatc attgacagtg aatacgatct gatggacgca 3595561 gcgaaaaaga tcgccgtcgg gaaattcgta aacgccggcc aaacctgcat cgcacctgat 3595621 tacctgttca ttaaaaaaga cgttcaggac aggttcgcgg ggattttaca aacagtcgtc 3595681 aacgctggat ttatggagga tgatcatacc ccagaccgca gcaaatttac gcagatcgtc 3595741 aatgaccgca acttcaaccg cgtcaaagat ctgttcgacg atgccatcga aagaggggcg 3595801 gaagtggtgt tcggcggcgt attcgatgcc agcgaccgca cgatctcgcc aaccgttttg 3595861 aaaaacgtca cgcctgacat gaaaatcatg caggaggaaa tcttcgcatc gatcctgcca 3595921 atgatgaact atgaagacat cgacgaggtc atcgattacg taaatgaccg cgataaaccg 3595981 cttgcacttt atgtgttcag caaaaaccaa gatctgattg acaacgtcct tcagcacacg 3596041 acatcaggaa atgccgccat caatgatgtc gtcgtccatt tcagtgacgt caacctgcca 3596101 ttcggcggcg tcaacacaag cggaatcggc tcctatcatg gggtatacgg attcaaagag 3596161 ttttctcatg agaagggtgt atttattcag gccgctgaat aatcgcatga tcaaaaggcg 3596221 cttccttaga ggagcgcctt ttattgtaac tccttgacca aaagcaattc atcacggata 3596281 ggtattttat tatctgccag taaaggaatt tcgggcttca tctttctggc cgtctcgact 3596341 gcattcacaa atagtcgatc caaccggtac cctctcttct gataaaacgc taatgcatga 3596401 atattatcat tggttgtgat cagttttatt tgtttgatat ttctctctct gcatgcttcc 3596461 tcggctttct ctagcagagc tgttccgatc cctttattct caatgacact atccagcgaa 3596521 atgatttcac aggcatcttc ttcaaatatg tatgtaataa ggccaacaat ctggttatca 3596581 tcgttgagca ttccataacc atctaattca tcgcagttat aaataccgct agaaataacc 3596641 atttgcggac tgccccagtg tttttgaaaa aacgcggaaa caagatcttt aggtacctgg 3596701 catgtcggaa taatattcat attttcctcc ttttagctga acaaaaataa gagaattaac 3596761 aacctatttt atgtcattaa tccccttatc tagtatttac tagaacttat aacttgtcaa 3596821 aagctgtctg aataccaatt gcgtggattg ataaggatca aaatctgaat cctgagattg 3596881 gaagatttgc tctggggtca atgtctctgc gttctctgat aacgtttgaa tcagactttc 3596941 caaatatcca tttaactctg atttggacga ttcatgtagg gattgatgat ttacagcgag 3597001 ttctctaaat ctgttatcac tgattaattt ttttcgaaga gctgctagca tcaagtcaag 3597061 ccatgcaggc tggccaaatg taatatttaa agctaacgtt gcttgatcag atttggtgga 3597121 gtgccataaa cctcttggca aatacagcat ggttcccggt gttaaattaa cgatttctgc 3597181 atctggcaga tcctcttttg gcggatctcc tttccaatat gactgtaaat catcaggata 3597241 gtaaggagcc tctgataaat catagtgctg cattggattg ctcacatttt cattcttggc 3597301 aagcttccat gttttctcac cttgaatttg aaaaatcaag ttggtgtagg cgtcaaaatg 3597361 ggctttgaat cccccgccat ttttcgccgc gtaaacaatg gctttggaag aagtacccgc 3597421 aggcagtctt aattccgctt tgagtttttc tatccacctt ctgacttggg gaataaatag 3597481 gtcggtgaaa tcaaactcta atgcagcccc tttttcatac cactctaaag cctctgcagg 3597541 tgacacaaga aatctgtctg tgatcccttc agattcttca atcacagcat caccaacgac 3597601 catgactgga ttattgtaga tagccaatac gttttctagc gttctaacct tttcaaaccc 3597661 cggtatgctt gtaaatctct ccacttctcc tctggctacc aaaggtttta caggccaata 3597721 ttcttctaaa aactcactca tcgttacagg actgatgata gactccaaaa ccgattcggt 3597781 tacagcactc atattatccc tcccaaaaaa agtaacttca ccacaaagat ataacatttt 3597841 tttctaaaag taaatattga cagaattatc agaggattat aatatttagt tgtgcgtgat 3597901 agcctatttt tttacaagga aggagggaaa aggatgaaaa aggcttataa gaaacctcgt 3597961 ctttttgaac tgcgccgtgc tgtagcagct ggcggccatt aatctcatat agcatttgac 3598021 atctagtact ctattttagg agggatgctc aatgaaaaaa gcttataaga aacctcgcct 3598081 ttttgaactg cgccgtgctg tagcagctgg cggccattaa tctcatatag catttgacat 3598141 ctagtactct attttaggag ggatgctcaa tgaaaaaagc ttataagaaa cctcgccttt 3598201 ttgaattgcg ccgcgctgta gcagctggcg gtcattaatc ttatccaaaa cgattaacgt 3598261 ttgaggctat cacgccaact tgataaggag gatgctgaag atgattacgg ctgaagaatg 3598321 cagaacgtac aaagaatttg ttgatcttta ccaatcctat ctttacccct tgcttggcgc 3598381 cagactgtcc cggatgtatt cccccaaaaa caaagtcatt atcgatatgg gcacaggtcc 3598441 aggttattta agcattcagt tggctaaaag aacaaatgcg cacgtgcatg ctgtcgatat 3598501 taacccggcc atgcatgaaa tcgctcaaga agaagctaaa aaaagcggag taagcagcct 3598561 gatttcattt gatttggaag atgtccacca tttatcttac gctgaccaat atgctgactt 3598621 catcgtctcc tactcttgcc tgcatcattg ggaagacgtt gttaaaggac ttaaagagtg 3598681 ctatagagtt ctggctccgg gcggaaaaat tgtcattttg gatacattta atccccaagg 3598741 aagccattta gagattatgc gaaaacaaat caaagaaccg gaatacttca ggtttgtaag 3598801 agaggcattt gaagaaagtt attcctttga agacattcac cagtttgttc aggatgccgg 3598861 cattcccaat tattcattag aaacctttca ctttttaccg gaggatttta tagaaagctt 3598921 agatgagctg gaggatgctc ccctgtggga acaaaatgat caaagtactg atcatgaaat 3598981 tgagtctgtc acatggatgt taacgataga aaaagaaaag gaaggtgcat tgtaatgatc 3599041 aatgaatcaa ctgttttatc caaaaatcca gaaatgccat caagaaaata tttgaaaagc 3599101 attattatag agccgggcat cactttaaat gaaatggcat cagatattta taaccatatc 3599161 gacggcaagg tcagcataca tgatatttgc tcaaaaatcg tcaatgaata tgatgttgat 3599221 tatcaaacct gcttagaaga ttgtatggag ctgtttgagt tgcttattga tcatgaagca 3599281 atcaaagtta agcagggggc atgagaattg gaaaaacaaa aagtgcttgc tttaccagac 3599341 gatgtacatg agctgagtac acaccgttct aaatcaatcg taaattacat catcactctg 3599401 cttgcctttg ccaaaaaaca aggattgact catcaagata ttgtaagctg gattcacgag 3599461 caatatgagg aaagaggata ttatgatgag tggagacaca ttaacagcca acaaccagtt 3599521 ggatcatttg tggaactctt tataaaagga agacgtttac tttatgacaa aattgaattg 3599581 tttgaaacag aagataaata tgtcgtaaat acccacactt ggtatgaaaa agaacctagt 3599641 gaggcctttt tttattttga aattgatccc gaagaatttt ctgcgtacgc ttccattctc 3599701 gcaatcgaaa acgcaaaacg tctcggaatt aaaatcgata ttgtaaaaga aacagatgta 3599761 gagacagctt atatctataa acatcaataa cgctattggg agggagacat atgtgcgggc 3599821 tcgcgggtat tataaatctg gctgctcccc gttctcagga atgtaccttt catatattga 3599881 aaggcatggc agatgccatc agctataggg gaccggatga tgaacaatat catattgatt 3599941 ccaaagtcgg ctttgcattt cggcgattgt ccattcttga ccttgtaaat ggacagcagc 3600001 cctttttaaa tgaggatgga tcaatcgtcg ttatggtaaa tggagaaatt tataactata 3600061 aagaactgaa ggcttcttta cacaatcata tgtttaaaac gacatctgat tgtgaagtaa 3600121 ttgttcattt atatgaagaa aaagggattg gatttgtaga cgacatcatc ggaatgtttt 3600181 caatagccat ttgggacaaa aataaaaaca aagtattttt agttcgtgac cgctttggga 3600241 ttaaaccgct tttttacaca gagctaaaac acgagcttat atttgcctct gaaataaaat 3600301 ccctattttc tcatcctcac tgtccccgcc aatttaattg gaaagaagca ctctcagaca 3600361 tttggctaag cggggaagca gccagtaatc ataaagaaac cacttccttt tttgtaaaca 3600421 tccaaaatct cgatgctggc cattatctcg aaattaattt gacaacaaat gaacgaaaaa 3600481 cagcaagcta ttggtcttta caggatattt tgctcaggca aggctatcgt gagaatctcc 3600541 atcccgatga cctgattgaa ggatatagag aactgctggc agattcagtc catagatgtt 3600601 tacaaagcga cgttgaagtc gggttgtttc ttagcggtgg cattgattca gctgcagtcg 3600661 cacattttgc tgcagaaaaa caggatctcc atacgtttac agtattaagc caaagtacat 3600721 ttacaaatga agatgcaaaa tatgcccatt ggctggctaa agatttacac cttccaaatc 3600781 atcaggttct ctatcaatta gggaacgatg agttattaca accagagtca tataaacatt 3600841 tgttatggat ctgtgaaaca ccgttttgcg gaccggaaca attatataag tttcatttac 3600901 ataagtatgc caaagcgata aggccaaacc tgaaagtcat gctgaccggc cagggcagcg 3600961 acgaatttaa cggcggttac agcacgacac tttcaccagc cgagaaccca agttgggaag 3601021 gatttattga atcggtcaat acgatggaga tgaaccggct gcatcggctg cagggaaata 3601081 tctttagagt gtgggaggag cattttggac tttctcctat aaacctttct tatttaaaga 3601141 gcaatgattc cagccaagca gatccttggc aatcgtatgt cctgacaaaa taccgtgatc 3601201 tgcaaatgta taattgctgg catgaagatc ggatcgccgc ggctaatcat atcgaaaacc 3601261 gtgtaccgtt cttggaccat cggcttgttg aatgggtttg cggaatacct gatggactcc 3601321 gtaaagactt gttatgggat aagtcggtat tgcgaaaatc attaacaaat gagctgcata 3601381 caagctatac ccaccggcca aaggttcctt ttttctatgg taaggacgtg agatatacac 3601441 ataaaatgat gtttcatctt ctgaagaaaa acaattatca gcttatagag gaggccttct 3601501 ctcacagcga tgcctccagc ataatacagg ttgaacacat tcatgccatc atgacatatt 3601561 tggaggatga tcctgagttt acaaattttg aatttttatt aagactggtg aacatgggac 3601621 ttttatcaaa aatgactaaa gaaacccctt ctgttcaatt agacataacc agccatttag 3601681 aatcgataac aataaaagac tggcactcac aggaaggtga tattgccagt cgtttaaata 3601741 tctcagccaa taagtgtgaa ggacaagata ttttggcgct aaaccctggc gtcactctgt 3601801 taaggccgga aagcgatagt gagcattgca tctacattgc ggaagaagga tttattcagt 3601861 ttattgtttc ggaggaagac gtcggagctt ggctgcatat tctctgcgat attaatggaa 3601921 aagacacact tcatacgatt ttagacagac atggtgtcag ccttgaagaa gtggccaaat 3601981 atattcaaga agccatcgaa cacaatatca ttttgatcaa acaaaaaaat ctgccagaag 3602041 gagcatatag atgagcatct tttattcgtt ttccgcactt aggggattag caatggggat 3602101 tttttcgcct atttggattc tttatctgat atctaaagat tatgatttcc ttcagattgg 3602161 attaatggga gcggtacttg aaattgctaa gcttatattt gaagttcctt ccggcgtttt 3602221 tgctgatcgt tatggaatta aaatttcaat tgccagttca ttctttttct ccatccttac 3602281 atgggccttc ttccctttta tcgattcagc tgctatttgc atactggcta tgatcatatg 3602341 ggctttatca gattccttaa tttccggttc ttttgaaact tggatgagcc gtgtcgcagg 3602401 ggaagatcga ttcggcaaag aaatgatgaa aaacacacaa ttgctaatca cttttttaat 3602461 tattggaagt attgccagcg ggtatttgta ttcattaaat atctattttc ctttcctgct 3602521 cgttatggtg atctacttat tactatttat ttggatgtct gtatttatta aagtcccttc 3602581 tgtttccgaa acaaatcatg gggatcagaa ccaacatgat tcgataaaga ttatcaaaga 3602641 aagtttaaaa attatcttta acaaaaaaag ggttctttta atcgtcatag ccggtttctt 3602701 tacagccaca gcctatgaca caatttcccg ttactggcag ccttttttga gtgatttagg 3602761 cttttcagaa aagtcactgg gatatatttt tgccctagga gggtttaccg ctctcgttct 3602821 tttgacatta accatcaggt tcgaaaagaa gatcgaaaaa aatccatatc tcgctttaac 3602881 ctcattggat tccatgggca tggtcatgac ttttctattg tctagagcat tcaggccgct 3602941 gggcattcca tgtacagcgt ttttgcttgc aattgaagat attcatcatc cgatcgtaac 3603001 aagttactta aataagtttt tccccgattc atacaagaac acacttttct cgttaaactc 3603061 aggggtagga gcaattggag aaattctttc cggtgtcatt ttcggcatca tttccgcagc 3603121 ctttgggctc tctgccatgt ttgttgttgt agctgtattt ctattaatcc ctattatcct 3603181 ttatacgata gtgcctaaga ttaaagacaa tgatatgaaa gttcagattg aaaaatccca 3603241 gcaagtgtaa atgttttgta tcacagtaag aagaccttct tattaaaaga aggtcttctg 3603301 ctattctatt cagttatttc ccaaaagcca tcagcttcgt ataacttcca atataaagtg 3603361 ttccgtcctc agcgagctga ggagaagaca cgacgttgct gtcggtttga tagctccata 3603421 attcattgcc gtttgcgtct gccgcataaa ccttcatatc atctgacccg aaataaaccg 3603481 ttcccttcgc gtcaatcagc ggcgccgttc tgacagggcc gtctgtgtag aatgaccagt 3603541 tcatatcccc gtttttgctg atggaaaaca gctcgccgct tcctgagccg atgtagatat 3603601 tgccattatg atcaatcgca ggagatgagc tggagaaccc gtttagcggg aatgtccatt 3603661 tcaaactgcc tgttgatgta taagcataca gctgtccatc ttggttgccg gcataaatgt 3603721 ttccgtcctt atcaatcacc ggatatcctt taaacgcatt tgacgtcgtt ctggaccatt 3603781 tcacctgtcc ggttccggag ttgatcgcat aaaacacgta attatatgtg ccgacataca 3603841 cggtgccgtt tttggcaagc accggcacag agctgacgac cccatttgtt ttcaacttcc 3603901 agcgctctgt ccaggttgat tttgacgtcg gtttgatcgc gtgaacataa ttatcaagtg 3603961 ttgagaaata caacgtcccg tctgaaccga tcaccgtttc agagcttggc ccgccgctta 3604021 acggaaccgt tgttaaaatt tctcccgttt ctttgtcaat aaaataaatc tttttgtcat 3604081 aggatgccaa atagataacg ccgttggtcc caagtacagg agattgcgta tatgtttttc 3604141 caagattgcc cgtcacccat ttgactgagc cgtctggatt aaaggctttc atttccccgt 3604201 ctctggaatg aagatatact gtgccgtctc cgtcaatcac agcccccgct ccattttgcg 3604261 gagtcgttct gatgtcgttt tgccatttca gcgtcccgtc tgtatttccg gcgaaccggc 3604321 tttcgcgtga ccagttaaac atggcaggcg ccatcgcttg tacatcatat cttcctggca 3604381 aaaagccaga tgctccatta ttttgagaaa acaccgtttc cgccgcataa gcagctgtcg 3604441 gctgaagcac tttggcagcg ggcacatcag aaacagcgcc ggccgaaaca gccgccgcca 3604501 ccgcagctcc cgcaatcaaa gctttcatac gaaatgactt gaccatcatt gagaccccca 3604561 ttatatgtaa cttctaattt gtgaccatca taacatattc atccatttta taaatctatt 3604621 tcacaaaaac atcacaaact agaaaactat gtaagagtat tcacggacgt tttttcagca 3604681 cccgatcgaa atgcagccac aaaccaaatg acgttgacag cagccgcagc gagactaact 3604741 cccaaaacaa agatcacctc agaaagcaga tggtcactaa agaaactaaa catcaagata 3604801 aaaccggccg aagacaaatg aatcaaaagc ccgaagccgc aaagcaccgc catgacatac 3604861 ctcattgcat cgactccgag catataaacg agaaatggaa tgaaatacaa gacaaggatc 3604921 ataccgacag ctgaccacat gccagctgaa ttaaactgat tggccgccgc tcccgttccg 3604981 gccagcggcg aaagtgaagc cgccacaatc acggcgcaaa aaagaaacgc agaaatggtt 3605041 gtcatgatcg ccacgctatt tttttttgac atcaaactcc tcctttaata gaaatattaa 3605101 ccttttttat tataagtaag ttgaatgtta tattcattat atttttaaaa aattccagaa 3605161 tacatacaca aatgctatgc ttctttctag tatatttata tagtaaaaaa caaaggataa 3605221 aagactcatt tttctgtaat atcaggattt tatcaccata ccatattgca tgtacatgtt 3605281 tttcaaagta tactattcca gattaattca gaggagagag aaaaatacat ggaaaaacca 3605341 gcaggatttt ggattcgttt tttagcttat tttattgacg gcattattgt atctgttcct 3605401 agttatatta ttctatttat tatcaattct gtgtttgtag ctggggctgt ggcaacaaac 3605461 ccttacatga cggaagaaga gtatttagtg aaatacatga cgcttgcatt tttgcctact 3605521 atgctgatca tgatcgtcat cagcgtgtta tattacgggc tgctcacagc ttctaaaatg 3605581 caaggcacac ttggcaaaaa aattcttggc ctgaaagtgg tcaatgaaca aggtgaacgg 3605641 gtttctgtcg gacagggaat tggccgttac tttgcctata tcttatctgg aatcatcttt 3605701 tatatcgggt ttatcatgat cgcctttgga gagaaaaaag gcctgcatga catcatttgc 3605761 aaaacacgtg tcgtgtataa ataatagaaa aaagtctaga cgccaatagg catctagact 3605821 tttgttttct ttgcaatagg ctgccacgac agatacgtag cgcttctcca caaccactca 3605881 aacggcccca tccgaaagac acgaagccaa aggtggctga agaccatttg aacggcacaa 3605941 acagcaattg taatgagcac accggcagca gggtacactt ttccatacag gcccaagccg 3606001 taatgataaa aaatccaagt acacacaata gactgcatca aataattggt aaatgccatc 3606061 ctcccaacag cggagaatga ttgcagcact gttctcactc ttgttttatg ataaagatag 3606121 acaaccgttg taacatagaa aaacatgagg aaaggcgcgc caatcagcaa acatatttct 3606181 ttatccgtta cactgtacag cacctgggcg ccgatgccga tgacaagccc agccatccat 3606241 aatcgtttta atcctttgcg atgcttttcc ggttcatgca aataccgtga ttttgctgcc 3606301 gcagctccca gcaaaaacat gctgaaatat ggaatggatg caaagaagta gttgagcgga 3606361 ttatacgtaa gcatgccatt cgaagacatg taaacaagac ggtcgtggat ccgctgttct 3606421 gcaatatcct tcaggctgcc gcttccataa acatgaatcg cttgttttgc ctgctgtgtt 3606481 accgcttgta cccattcctg tccgtttgat tgatcaaaac ttgtcaacat gaacggaatg 3606541 gaaaacagaa gatacaaaga gaccgcccat atcagcagtg ttttcggctt tgcttttcga 3606601 aacaagagca ggacaaatcc gagcagggca tattctgtta aaatatcccc gtcccatatc 3606661 aaaaaggcat gaatcgttcc aaacaagaga agcgccatta accttctcac atataacgga 3606721 acaaaccgtt tccctttgtt ttctgctctc tccatcatga caaccatgcc aaatccaaat 3606781 aaaaaggaaa acaataaaat acattttgtt tgaatgaaga atttcagtat gtctgcggcg 3606841 gcaaaatcag cttcagacca cttatccatg aaaaaattct cttttccaag catagacaaa 3606901 tacatatccg gataactgaa atgtgccaga ttgacaaata agatgccgaa aatcgccatt 3606961 cctctcagca catcaagcac accgatccgc tcatttgtta aagtcggctg taatgaagac 3607021 atagccatca cgctcctttt ttctgtacct taagggtagg aaaaaatgaa gcgcggtaac 3607081 atcgatttag gtgtcaggcc ggcatgaaaa ccttacaatc ttgtcatctt tatggtttca 3607141 tcacctttaa atctaatgct tcgatattct gcaaaatgcg atcaaagcgc aaagcctgag 3607201 gctcacatgg gaagatgtgg ccttcatacg ggtcgcctaa cgtccggaaa aacggttcaa 3607261 ataaaccagg aaccaatacg cccaccatct ttgtatagtg agaatcaagg cgataggagt 3607321 gaacggtatt tgcagggaca tgcaggaaat ctcccggatt cagctgaatt tcctggccat 3607381 ctgtccacat cgtcatctgg ccttcaaggc aataaaatgt ttctgtatga tattcatggt 3607441 agtgatcaac gattcggtca cctttagggc cttcagatga tacgacgata aactggccat 3607501 ctgtattttt ttgtgcagcc acaatgcggt gaagctgatc tccagtcaac agacgatctc 3607561 cttctccaga ttcaagaacg tatggaaccg ctccatctgg cagctctgta agttccgcta 3607621 atttggccga acatgcaggc tttgcttcat ctagaaatac aatgtccgct acagcggctg 3607681 cttctgcaaa tcgctcgttt gagacttctt cgcttgcgta cggcggatgt tcagcgtgat 3607741 catacggatt cccaataacg gaatacaagt gcgctacgtt tcctttcatc gtgtaagaca 3607801 ccagtcttgt tctgtggctc tgcatccggt agctgtgcgg tgttcccgcc ggaatgttgg 3607861 cataatcacc tgatattaat aaatagcgtt caccatcaag tgtcagttcc agtttcccgt 3607921 ccaaaacgag aattccttca tgtgtgtcct tgtggacgtg aagcggaaag gcatctcctt 3607981 ttcccccgga aagaagcacg atctcaaaca aatcacctgt gctcctccca ttcgccatca 3608041 ccgtggcaac ctgtctgccg aacagatagc gctcgccttc tccgctccgg agcaaataag 3608101 gcattttttc tttaggcaat gaatgtgtac ataatgtttt catattatcg cttcctccaa 3608161 tttagaccag tctatatatt atcattcatt tgtctagacc gttctatata attgtaggag 3608221 aaaggataac aaaatgctac cctttttttc tcaccagcac tggtatttgt tcggcaatga 3608281 gaagaagagg cgttttgtct ttattcgtta acgaaagcat gatgccgccc tcaatcatcg 3608341 aattaatcag cgttccaagc tgatttgctt cttcttctgc aaatccgttt tccattaatt 3608401 ttctggcaaa aaccgcttcc cagcttttaa acaccttcat gcaaaccgtc cgcagcggtt 3608461 cactgattaa cgctgtctca ctcgccagca aaccgactgg aataccttta atgctttctg 3608521 tgttgtcaaa ttggctggct gtttttttga taaaaagctg aatcgcttca acaggatcag 3608581 aggattcatc catgctttgc tgtatcagat gttcaacgat cttacctgta tatgtaaccg 3608641 cttcaattgc tagttcttct ttgccattcg gaaaaaagtg ataaagcgat ccttttggag 3608701 caccgctttc ttttacaatc tggttcaaac ctgtcgcgtg atatccttgc agctggaaca 3608761 gacgtgacgc cgtgtgaagg attttttcac gtgaatctcc tctgctagtc attaaaacat 3608821 tccctcctag gtatggtaga gcgacttata taatataaaa aagaaccctg tgattgtcaa 3608881 aaggggtaag acccttccgg atggggtaat gtacaaaaac agcgtctagg agggatctct 3608941 caatgacaat cgatcattca gtcacaaata cagagcagct tgaacaacag aaccccgcca 3609001 taaaaacaaa gctcaaactg aaaaagctta aggatcaggt gatcgtcatt accggcgctt 3609061 caagcggtat cggacttgtc acggcgagaa tggcagctga aaaaggcgca aaggtcgtgg 3609121 cagcagcgcg aaatgaagag gcgctgaagg agctcactga tgaacttaag gaaaaagggc 3609181 acgacgccat atgggtaaag gcggatgtcg gaaaagaaga ggacgtcaac cgcatcgcag 3609241 aaaccgcgat cagcacattc ggccgctttg atacatgggt caacaatgcg gccgtctcga 3609301 ctttcggaca cgccatggac gtcaccgtcg aagacatgaa gcgcatgttc gacacaaatt 3609361 tctggggacc tgtttacgga acaagagcgg ctgtcaaaca ctacaccggc agaggtgtgc 3609421 cgggcgcact cattaatgta ggaagcctgt tcggagacag gggaacggtc attcaatcca 3609481 catatgcatc tgccaaattt gcgcttcacg gctggacgga aagcatccga atggagcttg 3609541 aaaaggaaca ggcgcccgtc tcggtaacgc tcatccaccc gggcagaatt gacacaccat 3609601 ataacgagca tgcgcacagc tacctcgaca aacagccggc tcattaccgc tccatgatct 3609661 atccgccgga agcggtcgcc gaagcgatcc tgtttgccgc cgaacaccct aagcgcgaca 3609721 tgtacatcgg ctcacaggcc aaagccatcg ccatgctggg cgcgcttttt cctcgtctga 3609781 ccgacagact gatggaaaaa atcatgtatc acagccagca tgccgaaaga ccgtccaatc 3609841 cgagagaaga aagcgctctt tatgatgctg gctgcggtat gcatgacaga ggcacaaata 3609901 aaggatggat gaggtcaaga agctactaca caaaagcgac gaagcgccca attgtatcgg 3609961 cggctgttgt tgccggacta gtggcttggg ctgccgccaa acgatgcaga taatctctga 3610021 ccataagaaa aacccatgct gttccagcga accatgggtt tttcagctgt taatcgataa 3610081 aagccttgtt catacgctgc agcagctcgc cgaacatctc tttttcctgt gttgaccatt 3610141 ctttcagcat ctgttcataa cgttcaaggc gcttttgctg atcggctttt aatagttgtt 3610201 tgccgagttt tgtaatggta aacaggctga ctctcccatc agacgggtct gagaaacgat 3610261 agatgagctc ctttgcctct aatgcagctg cttgtcttga aagagtagaa atatcaagct 3610321 taaacgattc agccaattcc ttaacacgag caggcccaaa ctcatccaat tgtctcagta 3610381 ataagtacga agatctctcc aaattccctg ttcttttctc cgattgatcc agataaacag 3610441 ctctcctgat aaaagtcgtc agctcatatt caattaattc aactggattt tgattttgca 3610501 atcgctctcg ctccctattc caatctccgg cattgacaac atcatatata cttgtataat 3610561 acaaatgtac attaactgaa taaatacaag tcgttatatg actaaatcaa ttattatact 3610621 tgtatagtac aatcatataa aaagaaagta aagcgattcc tcagaaccat cctagaagca 3610681 agcaccagaa aggaggaagc tgttctgatt ggagagcagc acttgatgtg aaagtcatac 3610741 gaattatttt gcaagtgttg atattatatg tattttttat gatcggggaa gccattcagc 3610801 atctgtttca tttacccgtg tcaggaagca tcgttggatt ggtattgctt ctgatctgct 3610861 tgggcctccg tattgttccc gtctccatca ttgaagacgg agcagggttt ttattatcct 3610921 tccttccatt gttgttcatc ccggcaatga caggagtgat aaactatccg tctctcattt 3610981 cattcaatgg cctgatgctg ctgattacag tcgttctcag caccatcgtc acgatcattg 3611041 cggctggatt cgccagccag ctattagaga aaaaagcaaa aaaacgggag gagaaagaga 3611101 aatgcagcaa gcatgtatcg cgatcattat aattctttta acagttgccg cttatttagc 3611161 gatggtcaaa ctctataagc gattcccgct tccatttctg atccctgttc tgacaacgac 3611221 aattttgatt gtagcggctt tgatgatgtt tcatgtttcc tatgaaggct atatgatcgg 3611281 ggggaaatgg atcaattctt tgcttgggcc ggctgttgtg gcgctggcct atccgcttta 3611341 taagcaatgg catatcattg tcaaacattg tgttcccatt ttaggcggcg tcctggtcgg 3611401 cttatgcatg ggaatgatca gcgggctgat cttcgcagaa gcattcggga ttgatcatga 3611461 tctcttatta tccattctgc caaaatcgat cacaacccct gtcgctattc agatcgccgc 3611521 cggtcttggc ggcgtccctt ccatgacagt cgtatttgtc atgattgcgg gcttttcagg 3611581 cgtcatcctc gggccgcttt tcctaaaatg gcttcgcata cgcagctccc taggacaagg 3611641 cattgcatta ggcagcgcct cccatgcact gggtacctcc aaagcgttgg aatatgggga 3611701 attggccgta tccatgagtt ccgtctccat gacgctttgt gcggtgctcg gctcattctt 3611761 cggcccgctc gtcgtctggc tgtttcatat ttaacaaaga aagactgccc cgggggaggg 3611821 cagtcttttt cgtttaagaa gcaaaaaaat caatcaacgg ctgaaagtcc ttagataaat 3611881 caacgtcatt cggttctgct tgaagcaggc ggtcaatcat acgctccagc tcctcaacat 3611941 cattcttatc cgtatattca atgaagttta agctttcaag ccaatcccga tatgaatgtt 3612001 tggctttgcc atagctgttt ccaaagacaa ggcaaggtgt tttggtgata atcgagaaaa 3612061 tcatcgcgtg aaggcggtcg gtaatcacca atttactgga gccgatgcgg tccagcatct 3612121 ccataaaatg cttttcacga tcagcgtaat cgatggtgtc taccgtatcc agcaccgtat 3612181 cggtacgctc tgtgtaagtt gttttttctg cccattgctt catctgtgaa ataaaatctt 3612241 cgtcagtcac tttctcctta tccgctctta aaataaagag aacgccgtcc cgctcgagct 3612301 ctcgcggcac aatatccaag gaaagcacca tgtccggtgt aaagatcaca ttggagttga 3612361 aggtctcttt cacaacatcc agtgtttgcg tctcacgcgc agcaatcgtt aagtttgtat 3612421 tttgatggta cgcatcctgt gtttttttct tttccttctg tccttcctct gtatcctcaa 3612481 aataaacgga ttgtggcaga gaaattgatt tgtagtcttt aaacgccgaa aagacctttc 3612541 ttctgtcttc ctcaatatcg agataaaggt ttcctaaatt ccctccgcct gtaaagcaga 3612601 caatatcgtc ttcacgaatg atctccttca ccagttcaat gccctcatcc gtcgcataat 3612661 ccataatctc aatgtattca taatacggaa aatgattttt gataaatttc tcttccgcat 3612721 acgcaatcgc ttggtcgcca atgtttgtgt agctagggga accaaacaaa aatacttttc 3612781 gtttatcatt taacagagct tccggctcca catttggcgc aatgcctttt actagttttt 3612841 tgcctttgat ttcttgtaca gtcatatctg cgtcctcctt ctgggatgaa ttcctcattg 3612901 tgtgttaact gtctctaccc aaaaagaagg atggctatgc attggcatgt gcatcggcta 3612961 tatcagaaac atcgttttcg ccaatttgat agacgctgca atgtcccgcg ccgttctttc 3613021 catatattcc gcggcatgtt caaacgcgtc ttctagtggc acggctccgg ggacgatgct 3613081 gaaaagcgca tcgattccgt gttgatagac ggcattactg tctcgggaaa ttgatcccgc 3613141 aatgccgata acgggcacat cgtatgattt agcggccttg gccaccccga tcggtgtttt 3613201 tccatgaacc gtttggctgt cgattcgtcc ctcgccggta atcacaaggt ctgcatcctg 3613261 aacgatactt tcaaaatcaa ccgcttcaag gacaatatca atgcctcttt tcaggtcagc 3613321 ctgaagataa gttagcaggc tccatccaag accgcccgct gcaccggcgc cctctgtatc 3613381 tcggaaggtt gatccgagcg ctttttctgc catatcagcg aaatggctta cgttctggtc 3613441 tagtacatcc aacatgtcgg ccgtcgcgcc tttttgcggc ccgaaaacag ccgtagcacc 3613501 ctttggtcct gttaacggat tgtccacgtc acaggcaact tccagtttga cattccgcaa 3613561 tctggaatca agcccgctca catctattga tgcaagctga gataacgcgc cgccccctgg 3613621 gccaatctcg ctgcctgagt tatcaagaag ccttccgccc aatgcctgaa tcatcccggc 3613681 tcccccgtcg ttcgtggcgc ttccgccgat tccgatgatc aatcgctccg ctcccgcatc 3613741 aagagctgct ccgattaatt ctcccgttcc ccttgttgta gtgatgagcg gatttcgctt 3613801 atctacaggc accagatgca gccctgaagc agcagccatt tcaatcacag ctgttctccc 3613861 atctcccatc atgccaaaga aagctctcac cggttccccc agcggccctg tgacaacttg 3613921 ctctatgatc cttccattgg tcgcatcgac cagagattga acggttccct cgccgccatc 3613981 cgccaccggc aattttctgt aatcagcacc cggaaagacc gatttgaaac ctctttctat 3614041 cgcttcggct gcctccagag ctgataagct ttccttaaaa gaatcaggtg caatgatgat 3614101 tttcatccaa atcgcctctt tcaaaacatg attcacttaa cctattgatc tccaatgtac 3614161 cataattgat ctggaaatac ataccatgca atatggtaaa aatttaaata aaaattagaa 3614221 atgaaagtgt ttgcataaaa gaaatattca cgttatcata cttgtataca agtatactcc 3614281 ttgagtgagg aaggtgagtg tatgctagac tccaaagacc tgttgtatcc cgcaaaatgg 3614341 ctctcaaaag cgtcaaccgg agttcgtgtc gcatacgagc tgagaatgcg gatcgtttca 3614401 ggtctgattg aaagcggtac cattttatca gaaaatacaa tcgccgccga gttttcagta 3614461 agccgttcgc cggttcgcga agcgctaaaa atactcgcat ccgaaaaaat catccgctta 3614521 gaacgaatgg gagcggtcgt aattggttta actgagaaga aaatcgcgga aatttatgat 3614581 gtgcggttac tattagaaac atttgtcttt gaacggcttg tcaaaataga cattgagcct 3614641 ttagttaagg atctcagcaa aattcttgaa atgatgaaag tctcaatcaa atatgaggat 3614701 gctgacgaat tttcatttca agatgtgctg ttccatgaaa cgattatccg agcgattgat 3614761 cattcataca ttcagatgat ctggaacaat ctaaaacccg tcatggaaag ctttattctt 3614821 ttatcgatgc gggtacggtt aaaggaaaag tatgaagact tcacaaggat tttagataac 3614881 cacgagcttt atattcaagc catcaaaaca aaggataggg cgctgatgat tcagtctctt 3614941 caccaaaact ttgatgatgt gcaggataag gtagaagacc tatggctctc acaacaaatg 3615001 ctggcaaaag gagctgaata caacaatgac tagttatatg ttaggaatcg atatcggcac 3615061 gacaagcaca aaagctgtgc tgttcagtga aaacggagat gtggtacaga aagaaagcat 3615121 cggctacccg ctctatacac cggacatctc aacagctgaa caaaatccgg aagagatttt 3615181 tcaggcagtc atccatacaa cagcgagaat tacaaaacag catcccgaaa aacggatctc 3615241 tttcatttcg ttcagcagcg ccatgcacag cgtcattgca atcgacgaaa atgacaagcc 3615301 gctgacgcca tgcattacat gggccgacaa cagaagtgaa ggctgggcgc ataagatcaa 3615361 agaggaattg aacggacatg aggtgtacaa acggacggga acaccgattc atccgatggc 3615421 accgttaagt aaaattgcct ggatcacgaa tgaaagaaaa gaaatcgctt ccaaggcaaa 3615481 aaaatatatc ggcatcaaag aatacatttt taaacagctg ttcaatgagt atgtcatcga 3615541 ttactcattg gcatcagcga caggcatgat gaacctgaag ggcttggatt gggacgaaga 3615601 ggcactgcgc atcgcaggca tcacgccgga tcacttatcc aaactcgtgc cgacaaccga 3615661 gatctttcag cactgcagcc cggaaatagc gatccaaatg ggaatcgatc cggaaacgcc 3615721 ttttgtcatc ggcgccagcg acggcgtgct gtccaacctc ggcgtcaacg ccattaaaaa 3615781 gggtgaaatc gccgtcacca tcggtacaag cggtgccatt cggacgatta ttgacaagcc 3615841 gcaaaccgat gaaaaaggga gaattttttg ctatgccttg acggacaagc attgggttat 3615901 tgggggacct gtgaacaatg ggggcatcgt ccttcgctgg atcagagacg agtttgcctc 3615961 ctccgaaatc gaaacagcga cacggctggg cattgatcca tatgacgtgc tgacgaaaat 3616021 tgcccaacgc gtcagacccg gttctgacgg tctgctgttc cacccatatc tcgccggaga 3616081 acgcgctccg ttgtggaatc cggatgtacg cggctcattt ttcggcttga ccatgtcgca 3616141 taagaaagag catatgatac gcgcggcatt ggaaggcgtc atttacaacc tgtacacggt 3616201 gttcttggcg ttaactgaat gcatggatgg cccggtaacc cgcatccaag cgacaggggg 3616261 ttttgcaagg tcggaggttt ggcgccaaat gatgtcggat atcttcgaat cagaggttgt 3616321 cgttccggaa agctacgaaa gctcatgtct cggcgcctgc attttaggcc tgtatgcaac 3616381 aggaaaaatc gattctttcg acgccgtgtc cgatatgatc ggcagcacat acagacatac 3616441 gccgatcgaa gactcagcca aggaatacag aacattaatg ccgattttca tcaatctatc 3616501 aagattatta gaaaatcaat atacacaaat tgcagattat cagaggggct taatcacaca 3616561 caaatagtac atgacatgaa ggggagggca ttaccatgcc gttaatcatc gttgcacttg 3616621 ggatcttagc attactattt ctgattatgg gcttaaaatt aaacacattt atttccctgc 3616681 tggtcgtatc gttcggcgtg gcactggcac tcgggatgcc gttcgataaa gttgtcagct 3616741 ccatcgaagc aggaataggg gggactcttg gccacatcgc gctcatcttc ggactcggtg 3616801 cgatgctggg caaactgatc gcggattcag gaggcgcaca gcgcattgcg atgacgctcg 3616861 tcaacaaatt cggtgagaaa aatattcaat gggccgttgt cattgcctca ttcattattg 3616921 ggattgcgtt attttttgaa gtaggactgg ttctattaat tccgattgtc tttgcgattt 3616981 caagagaatt gaagatttct attttatttc tcggaatccc gatggtcgcg gcactatccg 3617041 tcacacacgg tttcctgccg ccgcacccgg gacctacggc gatcgccggt gagtatggcg 3617101 caaacattgg agaagtgctg ctgtacggct ttatcgttgc tgttccgaca gtgctcattg 3617161 cagggccgtt atttacaaag ttcgcgaaaa aaatcgttcc tgcatcattt gcgaaaaacg 3617221 gcaatattgc atcactcggc acacaaaaaa catttaacct tgaagaaaca cccggctttg 3617281 gaatcagtgt ctttactgca atgctcccga ttatcatcat gtcggtcgcg accattatcg 3617341 acctgcttca agaaacaatc gggtttgcag ataacggagt tttagctttt atcagattga 3617401 ttggaaacgc atcgactgct atgattattt cgttattggt cgcagtctat acaatgggca 3617461 tcaagcgcaa cattccagtc aaaaccgtga tggattcttg ttcaactgcc atttcacaaa 3617521 tcggcatgat gcttttgatc atcggaggag gcggcgcctt caaacaagtg ctgatcaacg 3617581 gcggtgtcgg cgattacgta gcagacttat tcaaaggaac ggcattatcg ccaatcattc 3617641 tggcatggct catcgcagcg atcctgcgca tttctctagg atcggcgact gttgccgcac 3617701 taagcacaac aggtctggtc attccgttat tgggccattc tgatgttaac ctggcgttag 3617761 tcgtactcgc aacaggagcc ggaagtgtca tcgcttcaca cgtcaatgac gccggcttct 3617821 ggatgttcaa ggaatacttc ggattaagca tgaaagaaac attcgccaca tggacattgc 3617881 tggaaaccat tatttccgtt gctggactgg gattcatttt attgttaagt ttagttgtat 3617941 gaaattaaga aggagctgta acacatgttc aattcgattg gtgtcatagg cttaggcgta 3618001 atgggaagca acatcgcctt aaacatggca aataaaggcg aaaacgtcgc tgtctataat 3618061 tacaccagag atttaacgga ccagcttatc caaaagctgg atggacaatc tctcagcccg 3618121 tattacgagc ttgaggactt tgttcaatcg ttagaaaaac caagaaaaat ctttttgatg 3618181 gtcacagcgg gaaaacccgt agattccgtc atccaatcat taaagccttt gcttgaagaa 3618241 ggcgacgtca tcatggacgg aggaaactcc cactatgaag acacagaaag aagatatgac 3618301 gagctgaagg aaaaagggat cggctacctg ggagtcggca tttccggcgg tgaagtcggt 3618361 gcgttaacag ggccttccat catgccgggc ggagatcgcg acgtctatga gaaagccgct 3618421 cctatcctga cgaaaatcgc agcccaagtc ggagatgacc cttgctgtgt ctatatcgga 3618481 ccaaaagggg cagggcactt tacaaaaatg gtgcacaacg gcattgaata tgccgacatg 3618541 cagctgattg cagaagctta tacgtttcta agagaaacgc ttcgtctgcc gctagatgaa 3618601 attgcatcta tttttgaaac atggaatcaa ggtgagctga aaagctattt aatagagatt 3618661 acagctgaga ttttacgcaa aaaagacgaa aaaacaggac agcctctgat cgatgtcatc 3618721 cttgataaaa ccggccaaaa aggcaccgga aaatggacga gcatgcaggc gattgataac 3618781 ggcatcccgt ccacgatcat cacagagtcc ttgttcgccc gctacttgtc atctttaaaa 3618841 gaagaacgga tggcagctca agatgtatta gcaggcccgg aagccgaaga aaaacacttg 3618901 gataaagaca cttggattga atacgtcaga caggctcttt acatggggaa agtatgcgcc 3618961 tatgcacaag gctttgccca atataagatg tcatctgagc tttacggctg gaatctgccg 3619021 ctcaaagaca tcgccttgat tttccgaggc ggctgcatca tccgcgctga tttcctaaac 3619081 gtgatcagcg aagcattcag tgagcagcca aatctggcta acctgctgat cgcgccttat 3619141 ttcacagata agctccatgc ctatcaaaca ggcctgcgaa aagtcgtttg cgagggtatc 3619201 agcaccggaa tctctttccc atgcttaact accgcgctct cttattacga cggctaccgc 3619261 acagggcgtt ccaatgcgaa cctcttgcag gcacagcgcg attactttgg cgctcacacg 3619321 tacgaacgga ctgatatgga cggcgtcttc catacgaatt ggtctgaata acctgtatta 3619381 aaaacacggt cagtttcaac tgaaccgtgt ttttttcttc tatcccaaac aacagaagac 3619441 ataagttatg ttttaaatat cataaacagt gatacaataa tagctagaaa caatccccaa 3619501 gatcatcatg tgacagcaga ttgctgttcc gttctattct gcttttggcc attgtccttt 3619561 gcccttgacc atggtgtcat aaaatgttca aatgccaaaa cggcctggca ttctgattta 3619621 caaaagtccc tgaaaacctt atctaattga gaatcagcct ctcatttatt ataaaagaaa 3619681 tgcctaaatc ctacctgtca cacctttatt aagatgaaaa aaagtaggtt atggcttgac 3619741 aaaaaatata tattaattaa taattcatat ataattagaa ttattattga aagcgattat 3619801 gctttctaat acatttttag gaggaatata cattatgtct ttaatcggta aagaagtact 3619861 tccattcgaa gcaaaagcat tcaaaaacgg tgaattcatc gatgtaacaa acgaagattt 3619921 gaaaggccaa tggagcgtat tctgcttcta cccagcagat ttctctttcg tatgcccaac 3619981 tgagcttgaa gatcttcaag aacaatatgc tgcacttaaa gaattaggtg ttgaagtata 3620041 ctctgtttct acagatactc acttcgtaca caaaggctgg catgacagct ctgaaaaaat 3620101 cagcaaaatc acttacgcaa tgatcggtga cccatctcaa acgatctctc gcaacttcga 3620161 tgttcttgac gaagaaactg gccttgctga ccgcggaaca ttcatcatcg atccagacgg 3620221 cgttatccaa actgttgaaa tcaatgcagg cggtatcggc cgtgacgcaa gcaaccttgt 3620281 aaacaaagta aaagcagctc aatacgttcg tcaaaaccca ggtgaagttt gcccggctaa 3620341 atgggaagaa ggcggcgaaa ctcttacacc tagccttgat ctagtaggta aaatctaagg 3620401 agtgcattca attggtactt gatgcaaata tcaaagcaca attaaatcaa tatatgcagc 3620461 taattgagaa tgacattgtt ctcaaagtta gcgcaggcga agatgacact tctaaggaca 3620521 tgctggctct cgttgatgag ctggcttcca tgtcatcgaa aatttcagtt gaaaaagctg 3620581 aattaaacag aacgccgagc ttcagtgtca atcgtgtcgg agaagacact ggcgtgactt 3620641 tcgccggtat ccctctgggc cacgaattca catcattagt gttggcgttg ctccaagtga 3620701 gcggcagacc gcctaaggta gaccaaaaag tcattgatca ggtgaagaag atcagtggtg 3620761 aataccactt cgaatcttat atcagcctga catgccacaa ctgtcctgat gttgtacaag 3620821 ctttaaacat gatgagcgtg ctgaacccga acattacgca cacgatgatt gacggtgcag 3620881 catacaaagc agaagttgaa agcaaaaaca tcatggcagt gccgaccgtt tacctgaatg 3620941 gcgaatcctt cggaagcggc cgtatgacgc ttgaagaaat tcttgcgaaa atgggcagcg 3621001 gcacagatgc atctgagttt gctgacaaag agccgtttga cgttcttgtg gtcggaggcg 3621061 gacctgctgg tgcaagtgca gcgatctaca ctgcacgtaa aggcatccga actggtgttg 3621121 tcgctgagcg cttcggcgga caggttctcg acaccatgag catcgaaaac ttcatcagcg 3621181 tcaaagcgac ggaaggaccg aagctagcgg caagtcttga agagcatgtg aaggaatatg 3621241 atattgatgt catgaacctt cagcgtgcga aacgccttga gaagaaagat ctgttcgaac 3621301 ttgaactcga aaacggcgct gtcctgaaaa gtaaaacagt gatcctttca acaggtgcac 3621361 gctggcgcaa tgtcaacgtc cccggtgaac aagagttcaa aaacaaaggt gtcgcatact 3621421 gcccgcactg tgatgggcca ttgtttgaag gcaaagacgt tgcggtaatc ggcggcggaa 3621481 actctggtat cgaagcagcg attgatcttg caggtattgt caatcacgtt actgtactag 3621541 aattcgcgcc ggaactgaaa gcagacgaag tcctgcaaaa acgtctctac agcctgccta 3621601 acgttactgt cgtgaaaaac gcacaaacaa aagaaatcac aggtgatcag agtgttaacg 3621661 gcatcacata tgtagaccgc gaaacaggcg aagaaaaaca cgttgaactt caaggtgtat 3621721 tcgtccaaat cggtctcgtg ccaaacacag aatggttaga aggaacggtt gaacgcaacc 3621781 gcatgggcga aattattgtc gacaaacacg gcgcaacaag cgtaccaggc ttatttgctg 3621841 ccggcgactg cacagacagt gcgtacaacc aaattattat ttctatggga tcaggtgcaa 3621901 ctgccgccct cggcgcgttt gattacctaa tccgtaacta atataagaaa tccgctatat 3621961 tgccagattg gcaggatagc ggatttttct ttttctacag aaaaaaaccg aaccaggcac 3622021 tacggtaaaa gtgctcgatt cgagcgcttc ttatagttcc tcaccattcg tttgaatgac 3622081 atttttatac cactcaaagg agtctttctt atatcgtttc atggatccgt ttccttcatt 3622141 gtcacgatca acatagatca tgccgtagcg ttttttcatt tcgccagttg tgaaggagac 3622201 aatatcaata atgccccacg gcgtgtagcc aattaaatca acaccatcgt acgtgaccgc 3622261 ttttttcaat gcttcaatat gcgattttaa atattgaatg cgttccggat catgaacctt 3622321 gccgtcctcc tccagcgtat ccactgcgcc aaagccattt tcaacgatga ataacgggat 3622381 ttggtatcgg tcataaaaac gatttaacgt atatctcaac ccggttggat caatcgccca 3622441 tccccagtca ctcgaagtga tgtacggatt ttcgacacca ttcggcaagc cgccatttac 3622501 aatatcgcca gtgttatcat ttttcacatc gcttttcaca gttgttgaca tgtaatagct 3622561 gaagcctaag taatcgacgg ttccgtttct taaaatctca tcatcgccgt cttcgaatgt 3622621 gatgttgtag ccttcgcgtt caaattcctt caacgcgtag cttggataat aaccgcgaac 3622681 ctgcacatca gggaagaaat agcgctgcct catttcttct tcagccagca tcacatcttc 3622741 aggattggag gagaaaggat aaatcggcac gtgtgatacc atggccccaa tctggaactc 3622801 tggattgatg tcttttcctt ttgccactgc taaggcgctc gccactaatt catggtgcgc 3622861 cgtttgatac atgacttcct tggcgttttc gttttcgcca accacaacac ctgaattcgt 3622921 ccataggaac agcggattgt tcacatccat ttggttgtta atctcgttaa atgtcatcca 3622981 gtacttcact ttatctttgt aacgggtaaa gcaagcctct gcgaagttga cgaagaagtc 3623041 cacgactttc cggtttctga agccgccata ttctcttgcc aggtgcagcg gcatttcaaa 3623101 gtgagacagg gtaatgaccg gctcgatccc atgcttcagc aattcatcaa acacatcatc 3623161 ataaaactgc aaaccagctt cgttcggttc agcctcatcg cctttcggaa aaatccggct 3623221 ccagccgatg gacgtccgca gacattttaa tcccatttcc gcaaacaaag cgatatcttc 3623281 cttgtatctg tgatagaaat caatggcttc atggtttgga taaaattcgt tttcttcaat 3623341 cgtgtcagtg atttttctcg gcacgccgtg cgcacccgct gtcatcacat cgacgacact 3623401 cggcccttta ccgccttgat tccatccgcc ttcaaattgg tgggcagcta aagcaccgcc 3623461 ccataaaaaa tcctttggca tgtttcccat gtttaattcc tcctcagctt acgactgtaa 3623521 atattttttg atgtaatgca ctttcctcaa tgtcttcaat gaaagcttta tcaaactcaa 3623581 caagcacttc gccttttttg acggtatcgc cttcttttac cttcaaggaa aaaggcgtgc 3623641 cgtcaaatgt caccgtatcc agcccgatgt gcgcaagcaa ttcgacgccg gacgctgaac 3623701 gcaggccaat cgcatgcttt gtaggcgtaa ccatgacaac cgtaatgacg ccgggatggt 3623761 agcatcgatt tcacgatatc cttcgcttta ggggtagacc gcttcagcac caatcgaagt 3623821 ctggtagcgc agcgagaagc cccaatcaca ttctcttccc cgcctacggc ctctaaaatg 3623881 tcttttgcta gtctcgtata atctctcact ttccccgaca tttcacccac cccttcgttt 3623941 tggttacgct ttcattataa ttgtaacggt ataatttatc aattccgaaa caaaatattt 3624001 acgcactaac tatcattgta agcggtttat gctataattt tgacaagtga aactaaacga 3624061 ataaatgagg aatgcgtatg ttaaaatacc agcaaatcgc aacggaaatt gaaacatata 3624121 tagaagaaca ccagcttcag cagggagaca aactgccagt cctagaaacc ctcatggccc 3624181 agtttgaagt cagcaaaagc accatcacaa agtccctcga gctattagag caaaaaggcg 3624241 cgatctttca ggtcagagga agcggcattt tcgtcagaaa acataaacga aaaggctata 3624301 tcagccttct gtcgaatcag ggatttaaaa aagatctcga ggatttcaac gtcacctcaa 3624361 aagtcatcga actggacgtg agaaagccaa caccggaagc ggcggaaaac ctgaacatcg 3624421 gaatggacga ggacatctac tatgtcaaaa gggtccgcta catcaacggc cagacccttt 3624481 gctacgaaga atcctattac accaaatcca tcgtgacgta tttaaacaac gaaatcgtct 3624541 cccactccat cttccattac atccgggaag gactggggtt gaagattggt ttttctgatt 3624601 tgtttctgca cgtgggccag cttaatgagg aagaagcgga atatttggga ttagaggctg 3624661 gactgccgaa gctgtatata gaaagtattt ttcacctgac aaatgggcag ccgtttgatt 3624721 actcgaagat ttcgtataat tatgagcagt cgcagtttgt ggtacaggct aatagttttt 3624781 tattataggg ctcttcacta cggtaggtgg tcgacatgta caaaattatc attcctgcca 3624841 tactagccat ctttgcgctc tggatactct tacagatttc actagagatg agcatcgtta 3624901 agaatccaat gaactacttt atcgtattca ttatcttttt cctctttgta aagatggtga 3624961 aagaaaaaca ataatagttt gggcgatgca aacagaaaaa catccttccc ttaacaaact 3625021 cagccagtca catgcattaa tcttgatgtt aatgatatat aggtgcacat aaaaagctac 3625081 ttcattgtga agtagctccc tttattaaag gcccattttg atccatctag ttttagaaaa 3625141 gcgaaggaca atcgcattta tgataataat tgaaactaaa tacaaaataa taaataaaac 3625201 atcattactc ccaagtgtca tgttatcaga ttgcagcact ctttctattc gggggtacat 3625261 agtgttacct gcctcaaaag gagcaatgaa accaaacgtt ttattgctta tagctactaa 3625321 gataacagaa gtcatccaat aaacgatact gacacctata ctaattaata tattaggaca 3625381 taacacgctt atagttccga taattagaat atactgcagt ataactgcag aaaataaaaa 3625441 aagtaataat gcaaaatgcg aaaaatcatg gtacatcaac gatatgatta gcaggcctag 3625501 cgttataaat gcaaaacatt ctaaaaataa aacagctatc tttttataaa agaaagtata 3625561 gatgttctct ccaattaact tgtaaaagag aatatttttg tttgaatact ctctattaat 3625621 aaagaaagct ataacaaatg aaaataacat caaaccaaac tgggtcgcaa cagtatagga 3625681 gctaaagaaa aacatttcag gtgtaacatt actgacttta tcgattccaa caagtaaaaa 3625741 ataacccagc aaaaataaaa atacaaacat tgctcctaaa ataatgataa ctttgttgct 3625801 aatactcttt ttaaactcta atttcatctc aagcccccac tgttttatta ctcatttata 3625861 tacacttcaa ttaatttatc cactgaatga tattgttgaa tttcttggtg attaaatata 3625921 taataatccc cttctatcgc ctttaaatca gacaaatcat gtgtaatgtt gatgataatc 3625981 ttctcggggt tctcctgaat atacttgttt aagaagccat gaatctctat aaccgttttt 3626041 ttgtctaatg aattcgttat ttcatctaaa acaataatat ttttatcctc taataagaaa 3626101 ctgagcaatt ttaatttttg cttttgtcca tcactcaaat ttttgatcag aacttttcca 3626161 tcaatattat ccagattaag taaatatgcg attttatcta tcatttttgc atcaaatttt 3626221 ttactcaaaa agtgtaataa aaagtcctta gaaacatcat taggtatatt cgacgagctg 3626281 gatattaaag aaacattttg acgaatatct ctgccgattc ttttgctatt attcaacaaa 3626341 aagtctttag caagctgtga tttaccgact ccattttttc cgacaacgtg attaattttc 3626401 ccgctcgaaa aatgcaagtc ggtgtcctga agtaacgttt tgcctttcac ttttaaagtg 3626461 taattcgcta tattcatata catactccta ggaaatattt gcataataat aaaatgttct 3626521 gccttgtgat ttgttactaa tgtctaagct tttgaggtac ctctttcgtt tccgatccgg 3626581 aagcgaaaga aatgttttta gatggctaat ttggagatct tttactctag tttacaatat 3626641 ataatatcca atgtacaact gaattcactg caaggccaat ccctataatt tgaatcgtaa 3626701 gaactaacca atgatttgtc ttaaaacggc tatattcatc taagctcaga aaagctaaaa 3626761 gaattttgta accatcagaa ttcaatattg ggattaagtt ccacaataaa gtagacgaga 3626821 aaagcataaa tgccatagtt aatgcttcac tggaaaatgt aaattgattt attaattcta 3626881 atgtatttat taaaagataa ttgataaaca agccaaataa atgaacgatt atcttttcat 3626941 ttcttgatag catgtaggtt tcattcaatt ggacataaaa agcaggaaat acataaaaat 3627001 tcagtttgaa tcccacttta tcaaagtttt tcccgaaaaa ttttaaggaa taaatatgtc 3627061 ccagttcatg aagcactata ttcattataa aataaataac tataattatc cacattttcc 3627121 agccgtaaaa tactgaggac aatccatttt gcaattttat taaatgaata taatttaata 3627181 tgaacatgag agccgtaaag gataagaaca gataaaaaaa ctttggtgat actttctctt 3627241 tatacatttt aaaacgtaat aattgtttat ctgacagaga atttaaacta tttttatagt 3627301 attctccgct ttttttgtct tttataaata cgttgttttg cacaagcact tcatattttt 3627361 catcttcata ctttaaaatt ttcattatag tatttttcca tataaggata gaagtagttt 3627421 attttttctg cagagttgaa taaggaacca caaactccac aaatagagga aaattcataa 3627481 ggaatgtcaa attcctctat tttgttattt tcttttaaaa tattcaaaaa ccatttgaat 3627541 ccttcttttc taagaataaa taatagcaaa ttggaattta acttttccac ggttctttcg 3627601 aaactttggt tatattcttc ccttagggtt attttcgttt caaaaatagc aggggaacaa 3627661 catggataaa tttctccatc atgatgatat acaatgtcat atccgggaca atgtaaggaa 3627721 tcttcatctt caagactgta aaatttatgt atgttttctt gcttaattct agttttagca 3627781 gcgccaactg atatcattgg aaattttgtt atctttacac ctaagattga atcccccaat 3627841 tcctctaaaa tgtggttgga cattttgtct ttggtaactg ccatattaag agaaatatcg 3627901 atatcagggt atttcctgct atgttctaat atgtttttaa tactggaaga cttgacaaat 3627961 ggagcatggt actcatcata acttatagtc agtgctatca catttaaaga attcatatca 3628021 tgaaagtact cctggacctt tttcttgctc aaaccccaaa atccattaga gatcaacgtt 3628081 atttgttttt catatggttt aatgatttcc attagttctt ttaaaaattt ataatctaaa 3628141 aaaacttccc cacctgtaaa agaaatcact tgaatggttt tgttttttgc aaattcagtt 3628201 actaactctc ttatgtattc tttttccatc ctggttgttg aagttggtga actagaaaaa 3628261 caacaatggt cacaggatgc attacacctt gaatctaaat tgattgatac tgttttatta 3628321 tacatgaaat atcccccaac aaatggtaaa ggagagttag actctccttt gtacccctct 3628381 aattaatgac cacttccaag aatccagcga ttttcttttg attttacaaa ataccaaaga 3628441 tcattcactt ttgctaactt ttgtgattca tctaatagac ccttaaattc taagtttttc 3628501 acagtctcat tgttagtgat ttcctttttc atattatccc tcctcctttt ctaatataaa 3628561 ccaattattc tatatcattc aatacatgtc aatatattgt acctaaaaaa tctgaaaaat 3628621 gtcactattc ttggtatata aagcctatag tcctctagcc cctctaagct ataccgaatg 3628681 aaaggccata gtttgattta aagcttcgta atgaaaagta aaacatcaat attgactaca 3628741 ctagttaagg gatatacaga ttttaagtgg aagaaatgag gcaaacaatc ttaccctaaa 3628801 ccaacctgta ctgaaaagct gttttaagct cttgcttacc ccatttggca cctctttctc 3628861 tcgttttaat tgtctctaaa agcagttatg cggtactatc atataaaggt ccaatgttta 3628921 aaaataatgt catactttta aattcacctt atcatgcaca tgctcataaa gaggggttta 3628981 ttctaaaaag gggatggacg gttttggaaa gcaagtacct agatctactc gcacaaaaat 3629041 acgattgtga agaaaaagtg gtaacagaaa tcatcaattt gaaagcgata ttgaacctgc 3629101 caaaaggcac cgagcatttt gtcagtgatc tgcacggaga gtatcaggca ttccagcacg 3629161 tgttgcgcaa tggttcagga cgagtcaaag agaagatacg cgacatcttc agcggtgtca 3629221 tttacgatag agaaattgat gaattagcag cattggtcta ttatccggaa gacaaactga 3629281 aattaatcaa acatgacttt gatgcgaaag aagcgttaaa cgagtggtat aaagaaacga 3629341 ttcatcgaat gattaagctc gtttcatatt gctcctctaa gtatacccgc tccaaattac 3629401 gcaaagcact gcctgcccaa tttgcttata ttacggagga gctgttatac aaaacagaac 3629461 aagctggcaa caaggagcaa tattactccg aaatcattga tcagatcatt gaacttggcc 3629521 aagccgataa gctgatcacc ggccttgctt acagcgttca gcgattggtg gtcgaccatc 3629581 tgcatgtggt cggcgatatt tatgaccgcg gcccgcagcc ggatagaatt atggaagaac 3629641 tgatcaacta tcattctgtc gatattcagt ggggaaatca cgatgtcctt tggatcggcg 3629701 cctattccgg ttccaaagtg tgcctggcca atattatccg catctgtgcc cgctacgaca 3629761 acctggatat tattgaggac gtgtacggca tcaacctgag accgctgctg aacctggccg 3629821 aaaaatatta tgatgataat ccagcgttcc gtccaaaagc agacgaaaac aggccagagg 3629881 atgagattaa gcaaatcaca aaaatccatc aagcgattgc catgatccaa ttcaagcttg 3629941 agagcccgat tatcaagaga cggccgaact ttaatatgga agagcggctg ttattagaga 3630001 aaatagacta tgacaaaaat gaaatcacgc tgaacggaaa aacatatcaa ctggaaaaca 3630061 cctgctttgc gacgattaat ccggagcagc cagatcagct attagaagaa gaagcagaag 3630121 tcatagacaa gctgctattc tctgtccagc attccgaaaa gctgggccgc catatgaatt 3630181 ttatgatgaa aaaaggcagc ctttatttaa aatataacgg caacctgttg attcacggct 3630241 gtattccagt tgatgaaaac ggcaatatgg aaacgatgat gattgaggat aaaccgtatg 3630301 cgggccgtga gctgctcgat gtatttgaac gattcttgcg ggaagccttt gcccacccgg 3630361 aagaaaccga tgacctggcg acagatatgg cttggtattt atggacaggc gaatactcct 3630421 ccctcttcgg aaaacgcgcc atgacgacat ttgagcgcta tttcatcaaa gagaaggaaa 3630481 cgcataaaga gaagaaaaac ccgtattatt atttacgaga agacgaggca acctgccgaa 3630541 acatcctggc agaattcggc ctcaatccag atcacggcca tatcatcaac ggccatacac 3630601 ctgtaaaaga aatcgaagga gaagacccaa tcaaagcaaa cggaaaaatg atcgtcatcg 3630661 acggcggctt ctccaaagcc taccaatcca caacaggcat cgccggctac acgctgctat 3630721 acaactccta cggcatgcag ctcgtcgccc ataaacactt caattccaag gcagaagtcc 3630781 taagcaccgg aaccgacgtc ttaacggtca aacgattagt ggacaaagag cttgagcgga 3630841 agaaagtgaa ggaaacgaat gtgggtgagg aattgttgca ggaagttgcg attttagaga 3630901 gtttgcggga gtatcggtat atgaagtgag gggtgtgggg ttcagggatg gtgatatgct 3630961 gctcccctaa aagtagatag atgaatttta gaaaatctgt ttgccttggg gagttttttc 3631021 atggctggac aattatacta caaggaagaa atactaatac ttatagaatg taattgggta 3631081 atgattcgga gaaagaggtt gcgaaataat atggtattac actgaaacaa ttatcaatgg 3631141 agaacatgca cgatatagcc gttctatatt ctccctctat tatggcactc attagtagac 3631201 ataaccgtaa aaaaatgcac tcaaaaaaag tccattctat ataactctcg ctagggtgga 3631261 cctttttcaa cattcaaagt actagatttt ttctagtgaa agaataagaa aagacataag 3631321 ttctatttta tcactctgtt ataggttaag ttattacggt gtttcattat atactgaatt 3631381 taaacaccct tgacattatg ggaattttta aaacaggtta aaaggaagtt ctataagaac 3631441 tccctagttt aatattattt ggtcaaaatc taaaaccaaa aaatctattt ttatcttcat 3631501 tgtttctatc taattttgca acaatcatac ctttcgactc taattcttga aggtcatcta 3631561 ataataattc atttttattt attgttacaa aatattgtcc gatcctattc tctaacagac 3631621 ttgaattgat atgttttaat aatgtacctt ttacatgagg atcaggatta gaataagatc 3631681 cgtcatgaat taaaatattc aaactacact tatttataca cctgtataaa aaccaagtaa 3631741 gatcaaatat atttatcttc atatggagtc taccatgtga acgttcatcc ggtatagaac 3631801 aagaaatttt gatccttcct gtagttgatt gttttgcgtt acttattcta ttatcatatt 3631861 caaaatctaa aaatccatgt tggttgtatg taacatccat tagattatta aaaagcttct 3631921 ttaactcact aactatagcg ctataagatt gaaactcatc ataatacatt gaattaactc 3631981 ttaatatttc atgttgaagt tcattaatct tatcaaaaat atggtttttt ttatcgtagt 3632041 cactaattct caatcttact tccgctaact ctatttcttt ccttctttgt tcttccatca 3632101 caatggaaat atcctcaatg aaattgttac tctttaaaat tctggcactt gattccagtt 3632161 gttctgttaa tccttgcttt ttgatattaa gtttttttaa atcggcttgt attttaacaa 3632221 ttttatcttt aaaataactc cctctacttt ctaccatgaa attatagaac tcttggactt 3632281 tattataatt ctgttttact tcctctggaa aaaaacctac aatatcttca tagaattttt 3632341 ctatattttc taattcttta atcttagtta cttttttatt taaatcatct atatttcttt 3632401 gatattgttt acaaatatgt tcattttcaa atatttcatt ttgtatttta ttaagttcac 3632461 ttttaatttc tgagtaccta tttgtatcat tattatattt attggcagtc ttagtttgat 3632521 agataactct attgtaatcc tctatctcat ttattaattc atcttcctta acttttaaat 3632581 cgccaatgtt aatattcatt gattcaatca attttatttc actatttaat ttttcaatct 3632641 tatcccgaaa aacctttatg tttttttctg tatgagttgg taaagtaaaa agatagttaa 3632701 gtaatttata ttgttttaac cctcccctat tcggtaaaac tatatcatta aaccctgtct 3632761 tttcgtctct tataatatac tcccttaacg ccgcaaaagt tatatcctct ttctcaccct 3632821 ttaaaatttc cttttcaata aattttttat atacacttat actaactttt ttccattcct 3632881 ccaaattaaa agttaaagaa gtatcatgta atgtataacc atgtttagga gaattaaaag 3632941 atctagcaag gaatacttga tttccatcaa tttccacatt caaaacaata aaaacgtttt 3633001 tattgagaag aatttcattt gtcgtataaa aatttgatat agtcttccct agtaaaaagg 3633061 agatgcattc aatcatcgtt gacttaccta caccattagt ctcttcatga tcttctctct 3633121 tttcaccaag tattatattt actcctacag cattaaattt atactctttc aaaatttctt 3633181 gggaattgca aacaaaaaga ttttttataa tcataacaat cactaactct ccgttctgct 3633241 aatcatattt tgattaaaag aaactttacc taatgaatat aaaaaagtta acgataaata 3633301 cagtatccgt tcaatattca aatttattat aataccttga ctcttagcat aatcaagaaa 3633361 aagttgatca atatgttttt ccttctctaa cagttcataa agtatctttg atgagtataa 3633421 aatattttct tccacagcat tatatttagt taataaaaaa tgattcattt ctggcctctc 3633481 cgccttttcc ttttttaaag gagaattatt cactagagga ataagatcat ttccaatttg 3633541 aatgttttta aactcatttt ctaataaaac ataagagtat ttgagaatat tttcagctgt 3633601 ttcaatttta agatcaatca ttcttaacac ttcttttgtt atcattaaaa atctcacatt 3633661 cataaatgca ccaacatgtt aaaatcttaa tgtatttttt cgttaaagcc tttgaatatg 3633721 gtaaaactga atgacattct agataaatct cattaacaat ttttacaaat atctcatctc 3633781 cattattata ttgattatga aactctagat atttgtctac tatcgtctca gcaatcaatt 3633841 cctttttatc agcacttaca tacgaagtgg aatccattat atggtttatc acaccaaaat 3633901 actcagaata actatcgaat ttccgtttaa aagtttcccc acttttcata tcataaaatt 3633961 ttttatctaa accaatttga ttatcaaaat tactagtaaa tgttttataa ctttctctat 3634021 actcatgaaa atctataata aagctcttaa actcatcttc atcaatttta tcatcgttat 3634081 cttctatttc tttttcaata aggctctcta atctattaat cttataattt aacttccctt 3634141 cctgtagtct ccttcctcct tggttgtttt ttgaccagta tttatattcg gtattccaaa 3634201 tgtagtatgt tacttctgtc tcgccattat ctaaattcac atccaccgaa ataaattctg 3634261 gagtagcata ctcatccttt ataatggctc cacttactaa ttctaagaat ggattttcat 3634321 ttgtatttgc agtaatatta aatgaagaat catgtacatg tcctgccaaa tatagatcaa 3634381 taaagtaatc atcaaaatgt gcctttattg attctctttc ggaagattca atacaaccta 3634441 acgtatggtg cccaatagct atatttaata ccttgccctt atttttctct ttgttcatct 3634501 tccttattgc tttatataat ttcatctgtg cagttaataa cgttccttct tcaccttttt 3634561 tatctgataa cagacatgta tttattgata aaacattata cttctccgat tgatacaaaa 3634621 aatgcaaatc ttcttccgga tatttaacac ccataaaatc ttcataaaaa tcgaaaaatt 3634681 tcctttgacc ttccactaat atatttgtag ctttttgatc tagtttatcc aacatttctg 3634741 aggggttagg agatttcata atactatcaa tcaaaagtgt cctcgtcatg tctctagata 3634801 tatcgtgatt tcctggcact aagtgtacgt tattcttact taatcccata cttttaataa 3634861 ttccattaag atattcttta acatcttcgt tatacacatc acctttgtgt gctatatctc 3634921 cagttaataa taaaaaatca aaatctgact ctcttcttaa aacttctata aaatctaata 3634981 atttatctct cattacaata gtgtcataat tttgaaactg aaaatgcaaa tcagaaattt 3635041 gtaaaaaacg taccttcaat acaaacatcc tctcataagt atatttatcc cctatatatt 3635101 tctagaaaac tttttattct atatcatctt tactctttaa tatattaaga ctctttccac 3635161 accatcaaat aaattataac ctaaacataa ctctttactc attttagtat tgtatttaag 3635221 tcaaacattg cattggttgc tgaaatatta tattcattga attattccat taaatagctt 3635281 ttagttgaac tttagtcttt ctgtaatggt ggagatgctc ttacttatga taaggctccc 3635341 cacgattaat ccgaaaagcc cgataaatct gctccactaa aataagccgc atcaactgat 3635401 gaggaaatgt catcttcgag aacgatagct tctcgtccgc tcgcttcatc accgtgtcac 3635461 tcaatccgag tgatccgccg atgacgaagg tgactttgct ttttccataa gtagccagct 3635521 tatctattgt atcggctagt tcttcggatg ttttcatttt tccttcgatg gcgagggcga 3635581 tgacgtgggc gtcggggctg attttggata ggatgcggtc gccttctttg tcttttatga 3635641 ttttcatgtc ctggtcgctt aggttttccg gcgctttttc gtccgggagt tcgatgatgt 3635701 cgatttttgc gtaggccgaa agtcgtttgg tgtattcttc aatgccttgc ttgaggtatt 3635761 tttcttttag ttttccgatt gtcacaatat tgatattcac aggtcatccc cactttaaaa 3635821 acaagttatt catatatgtt gtccacaatt gtggatatct tttctgtatt ttgtgtaaga 3635881 tcattcgttc cccactatat atactgcggg gtctccacat aattcacagg ctgtggataa 3635941 actgttagta tgttcgattt ttctgatttc gggcggcagc tcgtggtcgt ctatgtacat 3636001 atccagcacc gtttcgatgt gttcttcaca agaataatac gcttgtttca tgttcaaatc 3636061 ctccgatgtt ttcttccatt tttacaaatg ttctcttctc aatataacct atttattcac 3636121 atgttagtag tgcttcgggc tgagttttat ccacaattcg acaaacaagc tgttgatgac 3636181 tctatttcgc tcgtgtgtta gtttggatgt aaccgatgtg tggggaggtc tgcatttgcg 3636241 ctttagatgg gtttggcttt ttgtgattat gttgctgctt gctgagtgtc agccatctta 3636301 ttgggtgttg gagaaggatc gaatcggtga aggcagtcca gacttagaaa tatacgctaa 3636361 ttatctccaa atgcatgatg acgtgaaagg atatcaagtc ttcaccatat cagaaggcaa 3636421 aaaaatggtc gtcgtgtctc tcggaagcag cgagaaagat aagaagcttg aagtgtcgga 3636481 cgtcaaattc tcatctaaag aaacgattgt aactgtggag cgaaaacctg ctcctacggc 3636541 aaatgagaaa aaccctttta ttttgattgg actggacaaa attgaagggg atttaattgt 3636601 tcaagacgaa acaggagatc gctttgaaga aacggattac cagcaataaa gccggcgttc 3636661 tgagaacgtc cggctttttc ttttacttca atgtcccatg cgggtcgatg acgaattttt 3636721 tggctgcgcc tttgtcgaag tcgctgtagc cttttggcgc gtcgtccaga gaaataacgg 3636781 tggcattgac ggcttttgcg atctgcgctc tgccgctcag gatcgctttc atcaaattgc 3636841 ggttgtatgt catggcgggc gtttgtccgg tgacgaaggt gtgggctttg gcccagccga 3636901 gtccgaagcg gatttttaat gagcctgttt tggcgtccgc atcctttgca ccgggatctt 3636961 cggtcacgta taagcctgga atgccaaggc tgcctccgac ctgggtgacg tccatgattg 3637021 agttcagcac ggcggctggc gcttctcctt gattgccgtg cccagatgct tcaaagccga 3637081 cacagtccac tgcagcatca acggttggtt cacctagtat ttgttcaatt tgctcgccga 3637141 ggcggtcgtg tttttgcacg ttgaccgttt cacagccgaa gcttctggcc tgtgccagcc 3637201 tgtcttcgtt cagatcgccg acaatcacgg tagaggcgcc taggagctga gcggagtgtg 3637261 cagctgccaa gccgacagga cccgctccag cgatataaac ggttgaacct gtttgcacgc 3637321 ccgctgtata agctccatgg aagccggtcg gaaaaatgtc ggacagcatg gtcaaatcga 3637381 gaatcttttc tagcgcctgt tctttatcag ggaataccaa aagctgaaaa tcagcgtatg 3637441 gcaccatgac atattcagac tggccgccga cccagccgcc catatcgacg tagccgtaag 3637501 ccgatcccgg ccggtccgga ttgacattca ggcacacatg cgttttctgc gttttgcaca 3637561 tcacacagcg tccgcaggca atattgaaag gaacggatac gatatctcct tttttgataa 3637621 attcaacatc acgccccgtt tcaatgactt ctcccgtaat ttcatgcccg agcaccaagc 3637681 cttctggcgc cgttgtgcgg cctctgacca tatgctggtc gcttccgcaa atgttggttg 3637741 taatgacttt gagaataacc ccatgctcac attttcgatt cacattcgcc ttcgggacgc 3637801 cgggcccgtc cctcaagatt aactccggat aaccgatatc ctccaccgct acagtccctt 3637861 tgcctttgta cacaaccgct ttgtttcctg tcaacgccat tcctcccatt catgtgtttg 3637921 gactctccgt ccttgaacat gacttcggtt cggcatgact ctttcccttt ttcacgactg 3637981 ttttttctgt attcttacaa caacaaatat gccaagaaag catccaataa tggttccgcc 3638041 gatgtctaag aagtcgactt tacatccatt taacaagaac acagtaatgg ccgaaaccag 3638101 gcagatcata actgccagaa gaataacccg atttgtctgc atgtaattcc tcctttggat 3638161 tcgtttctaa accataccca aaatcctctg caaacttcgg ttcaacaaaa aaagagactt 3638221 cacaccagtc tcttcataaa cagagatcac tcaaaaaatt tcctgagaaa taatgtggca 3638281 acactcgtta ctaacgcaat tgccgtatac ataacaaccc aaaatatgaa tgagctattc 3638341 cccgaagcta acgtaactaa caatatcaag ctcgtgataa gaacgatgag cggtgccacc 3638401 caaaatcttt taaataaaaa atgacccgct ataccaaata cacctgcgac gatcggaaaa 3638461 ccaaaaacga taaataaaac ggcgatggct cccatactac cctccttgcc ttaaaacctc 3638521 ttcatcacct caacatcata cagcttcaaa tgactcttcg gcgtcacgac atcctttacc 3638581 ttcccaatct ctttttcttt cattttcttt ccggttttca ggctgtactg ttcaatgtag 3638641 gcaggcttgt gatacgtgta tgtgaagaaa tagaggctgc tgcctttttg ggtgatttct 3638701 ttgaattcgg ctttcatttt gtccggggaa agggtgaaga cgatgcttgt ttttcctgtc 3638761 ttggcatcga ttttgtgtac ctttccgaag ccgtcaatga aatacaggtt cccgtcataa 3638821 gggaaaaagc tgtttttaaa gctgaagggc atggagctgt atatcgtttg ttcgtcgttt 3638881 ttgtattcgg cgatatcgtg cagctctact tcgccgcttt ttttgttgat cttgaccatt 3638941 tgatagagat cgtgggcttt ttggccgcga accataacat acacagcttg gtcgtccacg 3639001 gcaagttggg attcgactga ggctccttcc cggtactgcc attccgttat gctgagatag 3639061 gtaagcttct tctgatctgc ttgaatctga aggagctgat agccttttcc gtcatctgtc 3639121 gggacgagtg cgtaaatggc gccatcatgg aaaccggagg ctcggatgta gtaggggatg 3639181 acgtcttttt tccactctcc gtccatttgg cggtacagct ctgagcggta tccgtctccc 3639241 tttttgtcgt agccggagtt gtataaggtg taaaagccgt ccgtgttttg cagaaagccc 3639301 gcgctgtcgc ctgtgtgctg ataggttctt ttatgggagc gcaggccgtt tttgatcgta 3639361 taaatcgtgt ttttgtcctc cagcatcacg ctgtcaccgt gaacctttgc tgagcccagc 3639421 tcaaggccct tcatctgaaa ggaagacagc gtcccgtcat ggctgataaa cagggcgtag 3639481 cttttcccgc cgccaaatgc atcttgatcc gcagaggatg agaaatacag caggacttct 3639541 ttgtcatcca ggaaatcggg atttctgaga tcctgctgac tcacggtttt atggcttttg 3639601 agaggagaaa tgaagacaaa tagtgcgatt cctgcgagaa tcagcatggc gatggtaatc 3639661 atccactttt tcatagcctt ctccttagta aatggtcata atggttgtcg tataagaaga 3639721 actagtgatg tcgcgcggat acacgcctaa gcctccgttg ctgtctatat caatccctgc 3639781 tttcagcaaa aaggcagacc ataggagctt tgaacagttt ttggcgccgt catggccggt 3639841 atttctgtta ttgacgaagt taaatgagta tgggtcgccg acttttgata ccgcccagtc 3639901 ggcagcagct gttttttgag atgaggatac gctgacggtt tgcacaatgg agttgtcttc 3639961 cacgtctctg gcattatacg cgatctgcct gacgccgtcg ctcgggacag attcaacaat 3640021 tttgtcagcg gcggagtaca tgccgacatg gccgtgattg tagtaggctg tgtaggagtt 3640081 cgtgtaatag atattgcctt tcgcgcttgt cgggagtttt ttcgtgccgg acgagccgcc 3640141 catgatagac atgccgcttt ccttggcgag ccggtccccc tctgctttat cagccgtgat 3640201 ctccttatag aactgtttta ggataacgtc ctgctttacg tgctgctgtt tggcaatctg 3640261 gctggcagat ttcatgattt cttccggtgt cgtgcctggc tgcagtgcgg cgatttcttc 3640321 agcataattt gtggtcttta cggctttggc gggagtaaca aacaggccgc cgcacattgt 3640381 gagcgctacc aaaaacatcg acactcgttt cttcaacttc attacatctc ctcttttctt 3640441 gtgagtgtag gaaaggtaat ttcctcaccc acattatatt aggaaaataa ggaaagtaac 3640501 taggttattt acagaatttt tagaaatcgt ttacagaaaa aggcctttat caggcccttt 3640561 tcgttaaagc ttcttgctca tcactacgtc tgtttcttga aatccggttt gctcatatag 3640621 ctttcgagcc gtctgattat gggcaaagac atgaagggac agcttgcgga ttcccatact 3640681 gcgtgccgct tgatctaatg ccgccaatgc ttgctttgcg tagccctttc cccgatacgg 3640741 ttcatataac ccgaaatcat aaataaacgc ttcctgctgc ggatgctccg gttcagcatg 3640801 tatccagagc cagccaacga tatccttttc attcagcttg aggctccaca aatggtgatg 3640861 gggtgtttcg agccctctcg gaagcagatc agtaaacacc tgcttagaca aaagctgggc 3640921 atcttcaggc agccatgttc ccgcttttac cttttcttcc gcgtaatgct ttgttgtgta 3640981 cgtgagataa gaccgaaatt cttctgtctg cataggggtt agcataattg tcatatcatc 3641041 tctccttcat atattgacta gaggatttta cataaaatag aaagaggtgt tactatcaga 3641101 ataagcaact gagattgata agtcactaga gaaaggagtt tcacatgaat aagatcgcac 3641161 ccgcagaaat cgctagcatg ctcaacgatt ggtaccttgc catcaagaaa catgaagttg 3641221 aagaatcctc ccgtttattt gaagaagtga agcctttatt ggatgacatg gaagaggatc 3641281 aggaggtgct tgcctacttc tccttattgg aactgcgcca caaggttttg cttcacgagg 3641341 cgagaggaca gggctttcag catgaggagc cttctcatat gaatgctacg tctgacatgc 3641401 tgaaatatta cttttttctg tttgaaggca tgtatgaggc ctataaaaat aattatgaca 3641461 ttgccattgg gctgtataaa gatgcagagc agtatctcga caacattccc gatccgattg 3641521 aaaaagccga atttcacctg aaggtcggta agctctatta taagctggga caaaatattg 3641581 tgtccctcaa tcatacacgg caagcagtca aaacattcag agaagagaca gattataaaa 3641641 agaagctggc ttcagccctg attaccatgt caggcaattt tacagagatg agccagtttg 3641701 aagaagctga ggcttatttg gacgaagcaa ttcggatcac gagtgaatta gaggatcatt 3641761 tttttgaagc ccagcttttg cataacttcg gccttctaca tgcgcaaagc ggcaaatcag 3641821 aagaagcggt ttcgaaatta gaggaggctc tacagaacga tgagtatgcc cgctccgcct 3641881 attattatca ttctgcctac ttgctgatac gagagctgtt taagatcaaa aagaaagaac 3641941 aggccttatc ttattaccaa gacgtgaagg aaaaattgac tgctgagccg aatagaatat 3642001 gtgaggcaaa aatagacatt ttatatgcca tttatgcaga agggggtcat gcggaaacgt 3642061 ttcacttatg caaacaacat atggatgact tgttgtccga gaaagagtat gacagtgtaa 3642121 gagaactttc cattttggct ggcgaacggt atagggaact tgagctttac aaagaagctg 3642181 cccacttttt ttatgaagca ttacagattg aagaactgat taaacgaacg gaggttatat 3642241 aaatgaaaag atttctgatt ggcgcaggcg tcgcagcggt gattttatca ggttggttta 3642301 ttgcggacca tcaaacccac tcacaggaaa tgaaagtcgc tgagaaaatg attggataaa 3642361 tgaaaaaccc ccgcgggatg cgggggttca atttaacgaa agaatcctaa aacggtttgt 3642421 agttttagga ttctttcatc ttttcagcgt gattgaaaac ccttgaagtc taggaagaac 3642481 gagcattgga gcgcagcgaa tgtttggaat tcgtgagcac cgaagcgcag gcctgacaac 3642541 gaatgcgagg gtttgtcgac acgctgaaac ccccgcgggt gcgggggttt tcttattaca 3642601 gcagcttctt ccctaacagg gattctacga gctctactgc tgttttgccc gttttgtttt 3642661 tgtgatcaag gatcgggtta acctcaacga attcggctga ggtaatgatg cctgcgtcat 3642721 acagcatttc catagccaaa tggctctccc ggtagctgat gccgccgacg acaggggttc 3642781 cgacacccgg tgcgtcgttc ggatcaagtc cgtccagatc aaggctcaga tggacgccat 3642841 cacatgctga taaataatca agggtttctt caatgacctt tgtcatgcca agacgatcga 3642901 tttcgtgcat tgtgtacacc ttcatgccgc tttccttaat gtacttgcgc tccccttcat 3642961 caagtgaccg ggcgccaatg atgacgacgt tttccggttt gattttaggc gcgtagcctt 3643021 caaggttaac cagtgactcg tggccaatgc ctaggctgac cgcgagcggc atgccgtgaa 3643081 tattgcccga tggtgaagtt tcaagtgtat tcaaatcgcc gtgcgcgtca taccagatga 3643141 cgccgagatt atcgtaatgc ttcgctgtgc ctgcaagcgt gccgatcgca atactgtggt 3643201 caccgcccag gacaagcggg aattttttct cttcaatgac tttgttgacc ttttgcgcga 3643261 gtttttcatt tcccgccaaa acggaattca ggtttttcag ttcctcgtca tttttgattt 3643321 tttcgcgatt gatcggaatg tcaccgagat cttcaaccgt ataccccatg tctgacagcc 3643381 tctcgatcag atgagcgtac cggatggcac tcgggcccat atccactccg cgtcgtgctt 3643441 gtcctaaatc cattggcatt ccaataaccg aaatcgtttt atccatctgt gattccacct 3643501 caacatttaa gataatgtcc tatgcgggtt ataacaaaga tgacttgcgg acaacgtttt 3643561 taaagctcta gctgacgatt tgcctgctgg cgttttttaa tgacgacatg ataaatgatg 3643621 tagcaaatga tcataaacgg tacgccgcaa tacagcgcga tacgctgctc cggatcaaat 3643681 gcaagactga tgagcacgac cgtatttaac gttaggccga tcagcggaag caccgggtac 3643741 agcggtgttt taaatttcaa atcttctatc ttcccgccct cacggatata tttgcgtctg 3643801 aacatgattt gggaaagcga gatcgtaatc cagccgacct gcgcgctcat gcccgccaaa 3643861 gataacagta ccatatatac ggtttcagcc tgcgcaaact ttgtcagaag tgataggcag 3643921 gccacagcca tcgttacgat taacgagtac atcggtacac cgcgctgatt tgttttgcca 3643981 agcgctttga aggcttgtcc ttcattcgcc atcgcgtaca gaatacgtgt tgatgcgtat 3644041 aaacctgagt tcgcaacaga taacagtgcg attaaaataa caaagttcat gatatcagct 3644101 gcatatggga ttccgatttg ctcaaatacg gcaacaaatg gactttccac gacacccgcc 3644161 tgtttccacg gaatcatgcc ggcaatgaca atgattgaaa gcacaaagaa cacaagcgtt 3644221 ctccatactg tctgtttgat ggaccgcgga atcgtttttt cagggtcttc actttctccg 3644281 gctgcaaccc cgatcagctc agtcccctga aacgcaaagt tcacagtaat catcgtaatc 3644341 agcattgcct ttatgccgtt cggaaataac ccgtcttcat aaaaatgtgt caaaaacggc 3644401 gcctgctctc cgcccttcag atcaatcagg ccaaacatgg cagctccgcc gagaataata 3644461 aataaaagga taatcaaaat tttaatgcct gagaaccaga attcagattc cgcaaaggct 3644521 tttgtggtga tcgcatttaa aataaacatc agtgccgcaa agaccagaca ccagatccac 3644581 acgtctatat gcggaaacca gcgttgcatc agctgccccg ctgataaaaa ttcaatggcg 3644641 catgtaaccg cccagccgag ccagtacagc cagccgaacg caaacccgaa ggccgggctg 3644701 ataaatttcg tggcataggt ctggaaggac cccgacacag gaaaggcgac tgccagctct 3644761 cctaagcaga gcatggtcaa aaacatgata aagccgccca ctaaatagga cagaaccgcg 3644821 ccgagcggtc ccgcttggtt aatggtaaac ccggttccaa ggaagaaacc ggttccgatc 3644881 actccgccca atgaaatcat gaacaaatgg cgtgatttca ttgtccgctg gagctgattt 3644941 ccgttatctt ggtttgtatt cacattctgc accccttcag caacttgtat tggatctaag 3645001 ctggaacatc tgcatggtgc tatcccagtt tgctgtccaa agagtctcta tctatttaat 3645061 ataaaattca cttcttctca taaagataca ttatactaaa atactgtagc tgagcaaata 3645121 gggagtgctg atttttctgt tgtaaattta tacaaacgaa gtgaatatcc cgccatggtg 3645181 cggatttatg cgtttcgcag cacgtgctta attttctcta tcgcccaatc caagtcctct 3645241 ttggaaatga ttaatggcgg tgcaaaacga atgactgtat catgcgtttc cttgcataaa 3645301 agtccctctt ccttcaaacg ctcacaatac ggacgtgccg cttcagtcaa ttccacaccg 3645361 ataaacagcc ctctgccgcg gacttcttta atgacagggc tgtcaatact ctcaagctcg 3645421 cttttaaagt attcaccaag ttcaagagaa cgatccgcca gcttttcatc ctccagcact 3645481 tctaatgaag cgatagacac tgcacatgca agcgggtttc caccaaatgt tgagccgtgt 3645541 gagccagggt taaacacgcc taggatctcg cggtccgccg caatgcaaga gatcgggaac 3645601 acaccgccgc caagcgcttt gcccaagata tacatatccg gaacaatgcc gtcccagtca 3645661 caggcaaacg tcttgcctgt acgtccgaga cccgtctgaa tttcatccgc aataaacaag 3645721 acattctctt ccttacaaat cgccgccgct tcctgtaaaa atccttcagg cggaatcaca 3645781 atgcccgctt cgccttgaat cggttcaaac aagaatgccg ctgtattcgg cgtaatggcc 3645841 tgtcgaagcg cttccacatc gccgtaagga atgagtttga ttcctggaag catcgggccg 3645901 aatcctcgtt tatattcctc ttcagaagaa agagataccg ccagcatcgt gcggccgtgg 3645961 aagttcccga cacatgcgat aatttccgct tgattgtcag ctacgccctt cacttcatac 3646021 gcccagcgtc tcgccgcttt caccgcggat tcaaccgctt cggctcctgt attcatcggc 3646081 agaatcatct ctttgcctgt cagtttagct gttttttcgt aaaacggccc aagctgatcg 3646141 ttatgaaacg cgcgtgacgt gagggtgatt ttatcagcct gatcctttaa tgcctgaatg 3646201 attttcgggt gtctgtgccc ctggtttacc gcagagtaag cactcagcat atccatatat 3646261 tcattgcctt ccgggtcctt tacccaagca cccagcgctt cagaaataac aatcgggagc 3646321 gggtgataat tgttggctcc gtaatgagac gtctgatcaa taatttcttt ggatttagat 3646381 aaagctgtca tatttgaatt cccccttgtt ttctgtttca acatgttatc ctgctttccc 3646441 tttatataaa tgcaagttct gtgccaaatc aagaattcgt gtgttttcta caattttcga 3646501 ggacaaggtg caaaaacatt ctgatatttc gagcgaaaat ttcagcaagt gcaaaattct 3646561 tttgcatatc ctctccgttt ttttataaaa tagaagcaat attaagaaaa taattgaggg 3646621 aggttcatac agtggtcaaa gacagcgaat tcctcacatt ggtttttcag agtattttag 3646681 atgaaatcga tgttggcctg cacgtggtag acgagcatgg aaacacaatc gtttataaca 3646741 ataaaatgat gcagattgaa gatatggaga agcatgacgt cttgaataaa aacctgatgg 3646801 atgtgtttat gttttcaaag cagcaggaca gcacactggt acaggctctt caggaaggca 3646861 agacgattaa aaacgtcaaa cagagctatt tcaataataa aggccaggaa attacgacga 3646921 tcaatcatac atatcccatc gtccaagacg gcaaaatcag gggcgccgtt gaaattgcca 3646981 aggatgtgac aaagctggaa cggctgatca gggagaatat gaacaaaaaa ggcagcacaa 3647041 cctatacgtt tgacagtatt ctcggcacca gtccggccat tcaagacgtc atcgaaaacg 3647101 ccaagcgggc aacccgtacg tcatcatctg tccttctagc aggcgaaacc ggcacgggaa 3647161 aagaactgtt cgcgcaaagt atccataatg gaagcgatcg ttctggcggc ccgtttattt 3647221 cgcaaaactg cgcggcactg ccagacagcc ttgtggaaag cattttgttt gggacgaaaa 3647281 aaggcgcgtt taccggcgct gtcgaccagc ccggcctgtt tgaacaagcc cacggcggca 3647341 cactgctgtt agatgaaatc aactcgctga atctcagcct tcaggcgaag ctgctgcgcg 3647401 cccttcaaga acggaaaatc aggcgcatcg gttcaacaaa ggatacaccg attgacgtac 3647461 gtattattgc cacgatgaat gaagacccaa ttgatgcaat tgcaggcgaa cgaatgcgga 3647521 aggacttgta ttacaggctg agtgtcgtca cactgatcat cccgccgctt cgggaacgaa 3647581 aagaagacat tttgcttctc gcgtcggagt tcatccagaa aaacaaccat ctgttccaaa 3647641 tgaatgttga acacatcagc gatgacgtga agcaattttt cctttcttat gactggccgg 3647701 gaaatattcg cgagcttgag catatgatcg aaggcgcaat gaatttcatg acggacgagc 3647761 aaacgattac ggcttcccat ctgccctatc aataccgcat gaaaatcaag ccggctgaca 3647821 tcccagagcc ggaaacacca agacaccagc cagccgcgga cttaaaagaa aaaatggaaa 3647881 gcttcgaaaa atatgtgata gagaacgtgt taagaaaaca cggccataac atctcgaaag 3647941 ctgctcagga gcttggcatc agcagacaaa gcctccaata tcggctgaag aaattttctc 3648001 actcgtctaa cgaataatcc ggagcaggaa gcctgatcag aaaaacagtg cctctgccga 3648061 tttcactttt cacttcaatc gtcccattgt gattgtcgat aatcgatttc gttatggcaa 3648121 ggcctaatcc cgaacctcca tatttccggg agcgggatgg gtctgccttg taaaaccggt 3648181 caaacactaa aaaacgtcac ttcttatgca ttgaagaaag aaaatggcac ctatgtgtat 3648241 cacagccagc aaccacacgg tacaaaccat taaagtccat gcaaataacg gaagtatttg 3648301 cagctaactg ccatttgctg tttcacgtgt aacatccatc ttgtattttt cttcatattc 3648361 gatatatcct ttttcaactg aacgggcgtg acccctgttc agtttttttt gcatatcaaa 3648421 acagcctggc aacgatgcca gactgctttt attaactgcc taattggtct gcggaggaca 3648481 gcttgatatc aacagatttt tcttttccgc cgcgataaaa cttcaccttc acccggtcac 3648541 cgactttttt ctgataaagc cgttttcgca ggtcaacaat atcatttact ttgtatccgt 3648601 caaattccgt gatgacatcc agttccttca gccccgcttt tccggcaggt gaaaaggcgt 3648661 ctacacccat cacaaccgct ccattggtga cgttcttagg aagctttaat gtttcatccc 3648721 aatgatagct tgcgatgtca cttagcgatt tcatctcaat gccaaggaac gggcgtttga 3648781 cctttccgta tctctctaaa tcctctatca cagggatcac gagcttagac ggaatggaca 3648841 ggccaatccc ttcaaccgct gactcggcaa ttttcattga attgatgcca atgaccttcc 3648901 catccatatt taacaaagcg ccgccgctgt tcccagggtt aatggccgca tctgtttgca 3648961 ggacttcagc gttccagtca ggctgtccat caccgtttga atctactggg atcgccctct 3649021 ccgtacccga gatgacgcct tgtgtgacag agcctgcaaa ctcaaggcct aacgggttcc 3649081 cgatcgcaat aaccggctcc ccagacttca ctttatctga atttccgaaa tcagcgactg 3649141 ctttaatctt atcgcttttc acccgtaaaa cggcaaggtc catcagctgg tcgctgccga 3649201 caagatcagc tgatacacgt gagccgtctt tcaagctgat ttcaatttgg gaagcgcctt 3649261 cgatgacatg atggttggtc acgacataag cggaatggtc atttttctta tagatgacgc 3649321 cagagccgct cccagcctcg ccgctctctc cccaaatatc tgatttttgg atgttcacaa 3649381 caccgacaac ggcgggcgac atattgctga caatcttggt gacggcattg ttgacactga 3649441 cattcaccgt cctgattgat tcccggccat tgttgttttg ctgctgatct aaggcgcctg 3649501 tatccagccc ttcatttgaa aggtacggca tgataaacgc cattaatacg gcaccgacaa 3649561 tcacgccaat cagactcgaa agaaaatatc cttttttgct tctctttggc tgttcaggag 3649621 tagtatgttc ttcctcacgt tcgtaatcca ccatattcca tcctttccaa gaacgttaat 3649681 atggttatat tgtgggttag aaactcctag aatagtcatg atttacatag aaaaattata 3649741 cagcgcaaag cggagtggcc ttcttcggat cggtgtcgta taagtcaaat gtctcacccg 3649801 tcacaaatcc tttagaagcc aatgtctgct gcacagacat tcttgccagc tccttcatgt 3649861 tgttgtcctg gctcaaatgc gccaggtaaa tacgagacgt ctcatcgcca atgacatccg 3649921 tcatcgccaa ggcagcatct tcatttgaca cgtgcccgac gtcacttaaa atccgccgct 3649981 taatgctcca tgggtatctt cccatttgca gcataccgac atcgtgattg ctttcaaaca 3650041 caaatacatt cgctgaacgg ataatgcctt tcatccggtc gctgacatat cccgtatctg 3650101 tcattaacgc gagctttcgg ccgctataat ggaatacata aaacatcggt tccgccgcat 3650161 cgtgggaaac gccaaacgat tcaacatcaa gtccgccgaa cgacttcacc gtctccattg 3650221 gaaatacaaa cttttgatcg gtgtcaattt tgccgatttg attctccatc gctttccaag 3650281 tcttctcatt cgcatagatc ggaagcttgt actttctggc gacgacacca aggcccttaa 3650341 tatggtcact atgctcatgc gtcacaaaaa tgccgtctac atcatccagc ttacgcccga 3650401 tctgcgccat cagcccatcc atggcttttc cgctcaaacc ggcgtccact aaaaatgcgt 3650461 gatcctctgt ttcgaggtaa aacgcatttc ccgtactccc gctcgcaagt acgctaaatt 3650521 gcaagctcat gtttgtctca ctccattatt ttcattgatc tgtatctaaa atcgtactct 3650581 ccaaagcatt cacagtaaaa tactcttgta ctgtcttttt ctcaccgttc acttttttct 3650641 cgtactcgac cgtaattctc cataccggcg ccagcacctg cgtacttgtc agcggatatt 3650701 gtgctacata gccgaattta cagctcttca cagtgctgta ttcttttaat tgattttgat 3650761 agtacaatag ctcaaccgca tccatttcag taattaagct ttctttctgg atttgcttga 3650821 aggtctcaag cgtagtctgg tcgtatgaca caacctcgtt tttaccgttt aagtgcagca 3650881 ccacttgccc gatcatatta gagggattgt cggtcttttg gtaaatataa tgaccttcgt 3650941 acgtttggaa gaaaataatt tctttcttcg atttatcaac cttccaaagc ttatattttt 3651001 cgccatcttg aattttcgaa gaaacaagtg cctgagcatc gtcctcgata tccttctttg 3651061 atagtgcgat tggatttgca aacttcattt tcaggctcgt tactttatga tcatcactag 3651121 gcatgtccat caaaggcttt tgatccttca gcgcctcaat ttcctccttg gagaaagact 3651181 tttgatttgc cgtgatccga tagccttctg ttgcttcctt attcaagcct tcatacgtga 3651241 tatgatcggc cttcatgtca tgctcgacat catttttaat gacttcatat tctttgccgg 3651301 tagcctgcca tttttgaaaa aactgatagc ctaagaaaat atctaaaatg aggaaggcaa 3651361 cgatgaagat tgattttgtc ttattccact ccactgttag ccccctcctt cctcaataaa 3651421 tcctttgtaa tcggcacaat ttttccattt actttcatcg cccaaaccgg ttccagttca 3651481 acgagaggat catcgttggt tgatgttgat accaattgat aagcaaggaa gatctgatca 3651541 attttgtccg tatcataagc ggtttgtttc gaaagcagca tcttcacttc gctgccgccc 3651601 atgagctctg tttcacttgt tttaatcgga ttcgttccga gactgtaatt cggccgctta 3651661 tagctgagaa tatcatcatt cgcccattgc accgtaatcg ccgatgtcgc cccgaaaggt 3651721 ttggcggtgc tgttaatgac cgggatctga tccataaaaa tatagaagct caactgctgg 3651781 ctgtcattga tattgaaaaa ttgatagtga tccgtccagc ttccggtatc ctcaaggtat 3651841 ttttggctct ttttgattaa ttcacctgtt tgataggatg tgctctgcac caaattgcgc 3651901 tgctgaaatt gcacctgtct ctggcttaga ttcacatcta accggctgat cccatctgtc 3651961 agcacatttc tgttggtgta attcgaatct tctcttacaa tgctcggatc actaaacaaa 3652021 gcctgcttaa aggtatttgt tttaatcgat tctgtgacaa attctttttt gtccatcgta 3652081 agcggtttgt tcggcagcaa gaactctttc tttgagccaa tggagaacaa actgaacgcc 3652141 ggcatatttg attgcctgtt tttcaagtcg ttcataatgt tccggtagtt tgctgattca 3652201 accgtcactt caagaatgag ctgcttgctg tatgacacca aatagatttt cttgttcgct 3652261 tttgtttcat tgaacgggat cagaatatgg tcaaacgaac tgtattcaaa cgactgatta 3652321 gaccatttaa acagcgtttg gaaaatatca atcgggatcg tatcgctgaa ttgcaagtca 3652381 agcttggctt cagaaccgcc tattccataa aaccagcttt tgaatccagc cttgtcatac 3652441 tgatccgaaa tatctttaat tcctttcaca tcccaatgcg gcaagtcaga ccaaatttct 3652501 tcatagaggg cattgtcatc cactttgtaa tgagcgccgt catcatggat aaacatgtcc 3652561 cttggcctta ccgtttcaga cagcttttgg gtggtttttt cgattttatg tttcacacga 3652621 acagtagact ctgttgagga tgagccttca gaaaagtttg gctggaacgt ccatatcccc 3652681 catgtaaaaa caagactgat gacgacgagt accgtaagta atatcgtttt tatattttca 3652741 cgcttcatcc caatcatcct cttgttcctc tttatatgga agagtaaatg taatcgtcgt 3652801 gccttttcct tctatgctgt ccgcccaaat atctccaccg tgcgcctgta ccatttcctt 3652861 ggcaatcgcc aatcccagac cggtgccgcc aagctttctc gttctcgctt tatccaccct 3652921 gtagaagcgg tcaaagactt tttcgacatc ttttttcgga atgccgatcc cttcatcctt 3652981 cacgctgata tagagaagtt cttcctcttc attgacatca atcgagaacg tgacatgtcc 3653041 gccttccggt gaatatttta aagcgttaga aataatatta tcgagcacct gcgttatttt 3653101 atcctggtca atctcgacat acagatctct gtccggcaga ttgcggataa actccacatg 3653161 ctgctctttt gtcatttcaa aacggtcaat aataagtgac ataaaccgga caatctgaat 3653221 ccattcccgg ttaaattgat aatctttact gtcaaatttc gacagctgaa gcagatcatt 3653281 gacaagccgg atcatacgct ctgtttcatt ttgcgtcacc attaagaagc gcggagcaat 3653341 gtctttattt tcccacgcgc cttcagctaa cgcttctaaa tagctgcgca ttgtcgtaag 3653401 cggcgtccgc agctcatgtg atacattcgc aacgaattct ctgcgttcct gatccatttt 3653461 ctcttgttcg gttacatcgt aaatgacagc gattaaacca tcaattttgc cgtgttccct 3653521 ttgaatcaca gagaaattca cgcgaagcac cgttaattca tcatcgcgct caatttcaag 3653581 cagcatagaa tcctgctgtt ccactaaatc ttcaaaagta taattctctt gaagccccag 3653641 caaactcgta atcggcattt ctaaggctgt ttcacgtgaa acgttcaaca gttccagcgc 3653701 cgggctgttt aagagaataa tcgctccgtt tcggtttgtg gcgataacgc cgtctgtcat 3653761 ataagcaatg acagaggcta gctttctgcg ttctccttca gtcatcgcct gggcatcttc 3653821 aagctctctc gttaagtggt taaacgttgt ggccagctgc ccaatttcat catgtccata 3653881 ctttttaacc ttcctcgaga aattcccttt cgcaagctcc atcgcctgct ttcgcatatc 3653941 tgaaagcggg tgggtaatgg ttcttgccag aaaaataccg agaagagccg tcaaaacaag 3654001 tgccaaacct gtgccggacg ccagtatcgt gttgatcgtc ttcatttgat taaagacatc 3654061 ttccatactc gcgacaacgt agatcgcgcc cacaacctct tggttttcag tcatgacggg 3654121 cttcgcggaa ataagaactc tgattttgct tttcgggtca taatattttc ttaaatacga 3654181 ctgtttggta gaaaagattc ttttgaaaat cagatcggtc gtttgtttcc cagccacttc 3654241 ctcaccgtac ggctttgaag aaccgaccac ttcatagctt ttatctacaa agctaatttc 3654301 ccgaacctca tcacttttcg tgaagtcatt caaaatacgg ctgacgtcat cctttatgac 3654361 ggtactgtcg ttatcgctct tatattcttg ttcgatataa taagaaaggt tgtcgattcg 3654421 ctgattcagc gattgttcat aagagctgat cagcgacttc tctacctgat tgacaaaata 3654481 cacaccaatg atttgcatgg caatgataat caaaagcaca taaatcaagg taatcttaaa 3654541 ttggatcgac cgaaaaaaac caaccttatt catatgggca ttagtcctgt tctgggtttc 3654601 tcaagtaata acctacacca cggcgtgtga cgatccaatt tggatggctc gggttgtcct 3654661 cgattttttc acgaagccgg cggactgtta cgtcaaccgt tctgacatcg ccgaagtaat 3654721 catagcccca aacggtttga agcaaatgtt cacgggtcat cacttgtccg atatgttttg 3654781 ctaaataatg aagcaattcg aactcacgat gagtcaattc gattgtttcg tctcgttttg 3654841 atacaacgta cgcgtcaggg aagatgacga gagagccgat atgaatctcg ttagaggaag 3654901 gctcttcctc cgcaggcgct gttgtcagct ggcggcgcag gttcgctttt acacgcgcca 3654961 agagctcgcg tgtgctgaat ggttttgtga catagtcatc agcaccgatt tcaagcccga 3655021 taaccttgtc aatttctgaa tccttagccg tcagcataat gattggcata tcgtatttct 3655081 ttctgacttc gcggcatact tcaacgccgt ctttatttgg gagcataata tctaaaagaa 3655141 ttaaatcagg ctgaagctct tctaccattt caacggcttc gtttccgtcg tgggcacagt 3655201 gcacttcata gccttctttt cttaagttaa attccaatat atctgcaatc ggtttttcat 3655261 catctactac aaggatcttt ttatccatca ttttgatttt cctcctgccg aatgacttca 3655321 tttcatctat ataacattcg tttcatcact tatggcccat gtaaagaatg ggtccttgtc 3655381 tattataacg gtttaaggtc aaaagataaa aaaaataaag gtttagaaaa aaaacacatg 3655441 tttcaccttt atcgccagtt gtttatctat tgtcatgctg gtcaactttt tttaaaaaag 3655501 ataactttat tgaaacctcc cctcaccgga gtgcgtcttt atcaatgacg tcttcttctt 3655561 tgaaccggcc gcagggccgg ttctcccttt ttcttctatt ataacactcc tcatgtttgc 3655621 ctttttccta aaagaaaaaa cgcacctacg attgcagatg cgtttggtaa gtggctcggg 3655681 acggaatcga accgccgaca cacggatttt cagtccgttg ctctaccaac tgagctaccg 3655741 agccaaatgt tttatttttc tctactaagt aaagtaaaat ggcggtccgg acgggactcg 3655801 aacccgcgac ctcctgcgtg acaggcaggc attctaacca actgaactac cggaccttac 3655861 agtaattgcc cggagagctg tcgtgtcagc tctcacagac aaataaggaa tttagcaata 3655921 acgctaaagt aaatcaatga cccgtacggg attcgaaccc gtgttaccgc cgtgaaaggg 3655981 cggtgtctta accgcttgac caacgggcct tcacgaaatg gtgagccatg aaggactcga 3656041 accttcgacc ctctgattaa aagtcagatg ctctaccaac tgagctaatg gctcttaaag 3656101 atgtcggaat ttctatagag caaacgactt aaatctagtt ctcatcttgt actctattga 3656161 agcagtttcc gtaacaacga gatttataat atcacgaaca aatagaagtg gcaataactt 3656221 ttttggtttt ttttcatatt tttttctcag accaacttat atgcggcttt caaacaaaaa 3656281 acaagcccct taaatagggg cttgcagaca tattctattt agttcgcacg gtacacactg 3656341 cgaaggacat ttgtttgtga gcggtctgga ccgacagaga aaatagaaag cggaatgcct 3656401 gtcagctgag acacacgctc aagataatgg cgcgcatttt ccggaagctc gctcaagctc 3656461 ttcgcacctg taatatcctc agtccagccc ggcatttctt catataccgg ctcacattca 3656521 gcaagtgcct taagacttgc tgggaattct tcaatgattt cgcctttgta gcggtacgcc 3656581 acacagattt tcaacgtttc aattcctgct aggacgtcaa ttgagttcag agaaagatct 3656641 gtaattccgc tcacacggcg ggcgtggcgg acaacaacgc tgtcaaacca gccgacacgg 3656701 cgcgggcggc ctgttgttgt tccatattcg cgtccgactt cacggatttg atcgccgatt 3656761 tcatctttca gctcagtcgg aaaaggaccg tcgccgacac gagtcgtata tgcttttgat 3656821 acaccgacaa cgtgcttgat tttggtcggg ccgacaccag aaccgatcgt gacaccgccg 3656881 gcaaccgggt tagatgacgt aacaaacggg tatgttcctt ggtcgatatc gagcataacc 3656941 ccttgtgcgc cttcaaataa tacacggcgc ccttcatcaa gagcatcgtt taagacaaca 3657001 gatgtatcgc aaacatactt tttaatctgc tgtccgtact cataatattc gtctaagata 3657061 tcctcaagtt taaacccttc tgtctcgtac attttctcga gaagacggtt tttttcttca 3657121 agattgcgct caagcttttc cgcaaacgcg tcacggtcta acagatccgc gatgcgaatt 3657181 ccgatgcggg ctgctttatc catgtaagca gggccgattc cttttttcgt tgtgccgatc 3657241 ttgttagccc ctttacgctc ttcttccact tcatccaatt tcaaatgata cggcagaatg 3657301 acgtgagctc tgttgctgat tctcaggtta tctgtactca cgttgcgctc atgaagatac 3657361 gcaagctctg tgactaatgc tttcggatct acaaccattc cgtttccgat tacacacgtt 3657421 ttatccttat agaaaattcc agacgggatt aagtgaagct tatatgtgat tccgtcaaac 3657481 ttgattgtat gccctgcgtt atttccgcct tgataacggg cgatcacttc tgcattttct 3657541 gataggaaat ctgtaatttt accttttcct tcatcgcccc attgcgtacc tactacaact 3657601 actgaagaca tgtccgtgca cctccgttaa cctttcaaaa cgattctatt caaacaaatc 3657661 aagtttatca gtgaagaaac agaaagtcaa ttgtaaatcc gaacattaat ttattgtaaa 3657721 tctatattcg ttcgcttcca ttcgttttat aagcgttttc tcactgcttt gtcataaaaa 3657781 gcttgcgaaa ctttcatcct ttagcataag aaagaatcac ttgcctgata tcccttttga 3657841 attcataaaa acgatccgcc agccgtccgg gtcctctatc gtcacgcccc cattgctcca 3657901 gtacgggttc tctgattcga cctcttgata gcccatgtgc tttagctttg aagtgatcgc 3657961 tgccagttca actgcattcg gcacataaaa aacaagaagg ctgtcgggat ggggaacggg 3658021 ggcagtgctt cccccttcat actgggtgaa ttccaaatga taatcggcat gaggaaggcc 3658081 gaacatgaca ccgtcatacc cgttatgctg tgaaaattct cctattcgtt tcaaacacag 3658141 tccctcttcg taaaaacgaa taatctcatc aagctggccc gtaggacgcg caattcggat 3658201 ttgtgctgct tgaaaagacg aaaaacgttt tcccatattg ttaccatctc ctttttgcac 3658261 cattttatta aaacgctttc aatttttcat ccgctgagcg aacgtcattt cttccatctt 3658321 tcgaatgaaa aaaaccccaa gagcagctct tggggcttat gcgccgggcg gaacgcctgc 3658381 gtcatcaaaa cgccgttcca ggttgacgaa tttgttgtat tcttttacga acgcaagaga 3658441 cacggttcct accgggccgt tacgctgttt ggcgataata atttcgataa tatttttatt 3658501 ctcggtttct ttgtcatagt agtcatcacg ataaaggaac gcgacaatat ccgcgtcctg 3658561 ctcgatactt cctgattccc ggatatcaga catcatcgga cgtttatcct gacgctgctc 3658621 aacacccctg gaaagctgag aaagcgcgat aacagggact tgcagctccc tcgcaatcga 3658681 cttcagttca cgggaaattt cagatacttc ctgctgacgg ttgtcctttg aacgaccgct 3658741 tccctgaatc aattgcaggt aatcgatcaa aatcatgccc agcccgcttt cctgcttcaa 3658801 gcggcggcac ttggcacgga tttcactcac tcgaataccc ggtgtatcat cgatgtaaat 3658861 cccgctgttc gataggcttc ccattgccat cgtcagcttg ccccaatcct cttcggtcag 3658921 gttacctgta cggagattct gggcattgat atttccctcg gcacagagca tacgcataac 3658981 gagctgctcg gcacccatct caagactgaa aatcgctacg ctctcatcgg tcttcgtcgc 3659041 cacgttttgt gcgatgttca gggcaaaggc tgttttccct actgaaggac gggcagccac 3659101 aatgatcaag tcgttgcgct ggaaacccgc agtcatccgg tcaagctccg taaaccctgt 3659161 tggaattccc gtgatatcac cttttcgatt gtgaagctgt tcgatattat cataggtctg 3659221 gacaaggacg tccttaatat tttggaaggc actcgtgttt ttgcgctgtg ccacttccat 3659281 aatcgttttt tccgcttcac tgagtaaatc ctcgacctca tcctcacggg tatacccgtc 3659341 ttgagcaatc gttgtcgcag ttctgattaa tcggcgaaga atcgattttt cctcaacgat 3659401 tttcgcgtaa tattctatgt tagccgctgt cggcaccgag tttgcgatat ctgtcaaata 3659461 tgaaataccg cctacttctt ccagcaggtc tgtgttcgca agctctgatg taactgtcac 3659521 cagatcaacc ggttcacctc ggtcaccgag caccagcatc gcattataga ttttttggtg 3659581 ggacattcta tagaaatcat ctggaatcaa tacttctgaa gccagtgtta aagcagacgg 3659641 ctgtaaaaaa atagcgccta acacggcttg ttcggcttct atattttgcg gaggaagccg 3659701 gtcattcaga aggtctgtca tgctaagcac cgtcctctca ttaaaaaatc tccaacctcc 3659761 attctaccat ttctacagaa aaaaaataga aaaattgtct gtttcctgtt tttttcagtt 3659821 agcagattgg atcgtttcgg acagtaacaa ggcgggaaaa atgcaataaa acataaggga 3659881 ggaatgaaag atgataaaga aatatgcgat tacacctaat gttgatgcgg acggctggtt 3659941 tattgaggtg gagaatgtag cgccgacagc tttgtatacg tctaaagacg ccgctattga 3660001 aaaggccaaa caggtggcta aggaaaacag tccgtctaag cttgtaattt atgaccagtt 3660061 taaaaatgtg gaagaagaac actcatttta atgaatgaaa gccttcgctg cagcgagggt 3660121 tttttagcgg ttatcggttt atttcatcca ttggatgcct atgtgcatca tcaaatctgc 3660181 cgctttttga tacagatccc actccccgat cgaagcaaat ttccccatca gctcctgaag 3660241 ctttaacctc attgctatat attcttcgaa agtgacagct ttttcagtgt ctatttggtg 3660301 ttccttcagc atttgtttta ataaggataa cggtgcgtgc ataagaaccc tccttacctc 3660361 ttttataacg gtcattttcc gattgctcta ttcctttgtg acatcttctt acatttcaca 3660421 tctgattctt gtacaatgga cagaagagag gagggatctt ttgtgagacc tttgcaaatt 3660481 tctgccgaaa ctgcacaaaa gcttgcagag tccttgaatc tgccgcttga acagatcatg 3660541 catatgcctc agcatattct gcttgccaaa atggctgaac tgcaaaaaga ggacaaatca 3660601 tagccttcat tcacatactt gcttacctgt ttcgggataa tatcatgtat atgttagaaa 3660661 agaggagtaa ctgctttgcc acatccacat aataaaaaaa tccaatcatt ttggctgatc 3660721 accggcatta tctttatcgc ctttaactta cggcccgcga tcacttcagt cggtccggtc 3660781 atcagctcta tccgggcaga gctgcacatg tccaatgggg cagccggttt tttgaccgca 3660841 ctgccgctgc tttcgtttgc agttctttct ccgcttgcac ctaagcttgg acagcgcctc 3660901 ggtaatgagc gaactttatg gctaggtctc gtgatactgc tgatcggtgt tctgactcgt 3660961 tctaccggct atactgccgc tttgtttttc ggaacagcac ttatcggcgt cgggattgcg 3661021 attggtaacg tacttttgcc aagcttaatc aaacataaat accctgaaaa gccagggatc 3661081 atgatcagcc tgtatacgac atcaatgaat atattcgcag ctttagcatc gggtgtcagc 3661141 gttcctttag cgacccagat gaatggcgga tggaaacaag cctttctctt atggggcggg 3661201 ctggctttac ttgcattgct aatctggata cctcagctgc gccatcgaga tacggcaaac 3661261 cagacaatga agctgcaatc cagttccatt tgggcttcca aaatggcatg gtatgtcacc 3661321 atctttatgg gcctgcaatc gtttttattt tacagcagca tcgcttggtt tcctgaaatt 3661381 ctccgttcac acgggattga tacggcaaca gccggatgga tggtatcact catgcaattt 3661441 gcgagtctgc cttccacttt tctgacgcca gttttagctg accgtgtgaa acagcagcgc 3661501 ggtatcgttg cggcgctggc ctcagtttat ctgatcggcc tttgcggatt attagcgggc 3661561 ggaagccata cattgcttgc catctggatg atcattatcg gtatcggaca aggctccagc 3661621 attagtctgg cccttacttt gattggtctc cgcagtgaaa atgcccaaca ggccgctgcg 3661681 ctgtcaggca tgtctcagtc attcggctac ctgctggcag cagtcgggcc aatctttgtc 3661741 ggctatctct ttgaccagac gcattcttgg acgatgccga ttgtgcttct cattgctgcc 3661801 ctgatcgtaa tgggagcagc cggacaggga gccggacgag atcgatacat tttccagtca 3661861 gaaaaacaaa gaaattcagc ataaagcggg gaagatatct ccgctttttt ctttgaatat 3661921 ttatggttta ttcataagtt tttcatattt gttttttaca atgagacacc ataaagaggt 3661981 gaaaaacgat gaaaaccaaa cgattcgacg cagcccttat tcttattttg ctagcagcag 3662041 cttttttgaa tacgtatcac atttggcagg atgatacagc aaaccagtac tatttggcgg 3662101 ctgtaaaaag catgacgcaa agcttccata acttttttta tgcgtcattt gacccttctg 3662161 gatttgtgac agtagataag cctcctgtcg tgttatggat tcaaacgatt ttcgcactga 3662221 ttttcggtgt tcacacgtgg agtgtcatca ttccccaggc tcttgccgga gttggatctg 3662281 tcttccttct ctacagaatg gttaagccga cttttggagt tggagcggcc cgcattgccg 3662341 cacttgtcat ggcactgacc cctatcgcag tagctgtcag ccggacaaac aatatcgaca 3662401 gcatgcttgt ttttacctta ttgctcggtt caacttgtct gcttagggca gtaaaacaag 3662461 gcaagctggt ttggctgctg acggcatttg ccctgattgg gctcgccttt aatatgaaga 3662521 tgatgcaagc gtttatggta ttgcctgcat ttgtgttatt ctacctgatt gcatctcggg 3662581 tttctctgaa gaaaaaaatc gggtccctgc ttctgtctct tgtccttctg acaggccttt 3662641 cactctcatg ggcgattgca gtggattcag cctcttcctc aagccggcct tatgtaggaa 3662701 gcagccagac taactcagtg ctagaactgg cctttggcta caacggcaca gagcgtctgt 3662761 ttgggcaaac tacgggcctt gcaaagggtg atatgaatgc tgctggcgga gggaacatgc 3662821 agaatcaaga caacatgcaa gcgccaaatg gcaacggttc atctttttct cagaacggta 3662881 atcaatcatt cggaaaccat tcacaggcgc ctcagccgcc taacggacaa accggcgctc 3662941 tcaatggagg cggaggcaca cctcccacag gtggcaacgg acctggaaat ggagggcctg 3663001 gcggcggagg cggaaaaagc gtgaatatgt tcggcaccgg tgatcctgga ccgcttcgtc 3663061 tcttccaatc agcactttcc ggccaaatca gctggatgct tccattctca ttgatcggat 3663121 tactgggcgc aatcatcagc tggtaccgtg atcgccgcgg acatgctgct aaaatgaaag 3663181 aaacgctatt ctgggcggct tggcttgttc ccgtggctgg tttcttcagc atcgcaggat 3663241 tcttccacca gtattatttg attatgctgg caccgccgat tgccgccctt tctggtatcg 3663301 gatggtatac gatgcaccgc ttatacaaaa ataataaaga ctggtccagc tatcttctgc 3663361 cggcagccgt cttgatcaca gccgtgtttc aggtgtatat tctgagcgct tatacaagcc 3663421 aaatcggcag tgtatggatg tatgtcctgg ggctcttagg actgggcatc acccttgcac 3663481 ttctgatgct taaacgcagc catccgttca gtaagctgct gaccatcatc agcttgtgcg 3663541 ttctgcttct cacaccagtt tactggtcag caacgccgct tctatacggt ggcaacagcg 3663601 tccttcctga atccggcccg cagctcaaag gctcagcaaa cggcgggaac atgttctctt 3663661 cagaggtcga cagcgggctc ctgtcctatc tgagaaaaca caataccggc gaagagtatt 3663721 tatttgctac tttgacaacc gtaacagctg cgccatacat catttacgaa aatgaatctg 3663781 ttatggcaat gggcgggttt aacggcacgg atcccattct gactgtgtcg gaactgaaaa 3663841 aactgatcaa agaaggcaaa gtgaaatact tccttctgtc agaaaacaac tcaggcaaca 3663901 gcgaacttgt ttcctggatt aagaaaaacg gaaaagaaat aacatctgac gagtacagcg 3663961 gttcctccag cagcacaaac agcgtgcagg gaatgcgaag aggacctggc ggagaaagcc 3664021 agcaaactct ttatctcgtg gaataaaaaa agaggcttgg atgaatccaa gcctcttttc 3664081 tattaagctt cttcttttac atgtaccttt aacacagcct gcacttcagg atgcagcttc 3664141 acaggcacgt ttgtatatcc taatgcacga atgccgtccg gcagttcaag cttccgctta 3664201 tctactttaa tgttatggtc tttttggagc tgttcagtga tttgcttgct tgtcactgaa 3664261 ccaaataaac ggccgccctc acctgatttt gcgctaagct caacagtcag tttttctaat 3664321 gtctctttca agctcttagc ctgctcaagc tcagcaatgg cttctttttt ctctttctgc 3664381 ttttgtccgt ttaacgcgct gatgtttgac gcgttcgctt caaccgcgag gcctttttta 3664441 attagaaagt tatgcgcata accgtctgct acgtttttga cttcgccttt ttttcctttt 3664501 ccttttacat cttgtaagaa aataaccttc atctctgtac gcctccctca aaatactcat 3664561 ctatggcgtg cttcagccgt tccagcgctt cagaaactga aatgccggac aactgagtcg 3664621 ccgcatttgt taaatgccct ccgccttcca gggcctccat gatgatctga acatttacct 3664681 cgccaagcga ccgagcactg atacaaaccg tttgttcatc ccgtctcgcc accgcaaatg 3664741 aagcctcaac ctcactcatc gatagcagcg aatcggcagc ctgcgcaatc agcacttgat 3664801 cgaagtattc ctcttcattt tcaggaagag aagcaatcgc aatgttatct ttatagagga 3664861 ccgtatgctg gatcagcttc gcccgtttaa tataggaatc aacggtttct ttcagaaact 3664921 tctgcaccag caccgtgtcg gcgccttttg cccttaaata agaagccgca tcgaaagtcc 3664981 gcgagcccgt gcggagagaa aagctctttg tatccactat tataccagct aatagggctg 3665041 ttgcttcaat catattgatt tttaagcgct tcggctgata ttcaagcagc tctgtcacca 3665101 attccgctgt ggaagaagcg tatggttcca tataaacgag cagcggatct ctgataaact 3665161 cctcacctct tcggtgatgg tcgatgacca cgatatgttc aattttattg accagccgtt 3665221 cctccatgac gagtgacggc ttatgtgtat caacgatcac aagcagtgtg tcatcattgg 3665281 aaatctccat tgcttcttca ggcgtaataa atcttgacca cagttcttca tattttttga 3665341 tttccccaat caaacgctgc acacttgatc cgatttggtt tgggtcaatc acgataaaac 3665401 catctttgtt atttgcctga gccaccttta aaatcccgat cgctgcgccg atagaatcca 3665461 tgtcggggaa tttatgcccc atgataatca cattgctgct ttcggtgacg atttccttta 3665521 aggcgtgaga aatcacgcgg gcccgcaccc ttgttcgttt ctccattggg tttgttttac 3665581 cgccgtaaaa cttcaccttg ccgtttggca gcttaatggc tacctggtct ccgccgcgtc 3665641 ccagtgctaa gtccaagctg gattgcgcca aatcgccaag ttctttcagg gaagagactg 3665701 aagccccgac accgacgctt aacgtcagcg ctacaccgtc aaacgaggtt ttttcccgca 3665761 cttcatcaag aatcgaaaac ttcgaatttt cgagttcagt taagatatgt tcattaagta 3665821 cagcaataaa gcgttctgaa gacgtccttt tcaagaagat cccgtactcc tgcgcccaag 3665881 cgttcagcaa agatgtcacc tggctgttca tcgtgcttct cgtctggtca tccaatcctt 3665941 gtgtcacatc atcatagtta tcaaggaaaa tatatgccag gacggttctt tcgttttcat 3666001 atagcttttc aatctggatt tgttctgtta catcaaagaa atataagaga cgctcatccc 3666061 gtttgatgac aaccctaaac ttgcggtcat tcaatgtaac cgtttccgat tccacctctt 3666121 gtttgataag cggcactacc gattcacaag tatcgtaaag tgatctcccc actaaagtgc 3666181 tttcattaaa acaagaggaa agaaacggat ttgcccattc tatataatat tggtcattaa 3666241 aaagcatgat tccaatcggc atttccatca atgcctcttc accgactttt ttcaacctgt 3666301 aggacaacgt agaaatataa gcatcaatct cttgtcgaat aagagaatca gcacgcttaa 3666361 taaaaaacaa aataactgcc agcagcagca cttcgacggt tcctaatatc cagttaaaat 3666421 aaaagctgat gaggattgta ataattgaca gagcaatcaa tgcatagatg ggataccgaa 3666481 acagcggttt ttcataaaag cttggcattt ctatcactcc ccaccatgtg agtaaaactc 3666541 atgttcactt caccttattc cttatatgaa agcccatatc taaaacgcct aaaatgcgaa 3666601 tggccgccat gaagaccgga tgcacaaacc caagtatgac agcaatcaca gccgcagcct 3666661 ttggatattg tttcttatgg caatagaaaa agataaatga taaaccttgg atgaaaatca 3666721 gaaacccgag tataaactcc ccatttaaag cgatagagta cagcatttgg cctttttcta 3666781 aaggcaaaaa tgaaagcatg acaataatca aatacagtac tacaacactt tgcggaaact 3666841 tcaactctct aaaaggcttt agattaggaa tatcggggga gaatcgcctt aagagcggct 3666901 tagcgataag gtaactgagg aaagaaaaaa taactcctac catcacaata gctgttggaa 3666961 aaagatattg aacgataccc aattgttctt ccatcagttt taattgcttc tcaaactgcc 3667021 cagcattgcc cgactgcttc gctacagttt ctacaatatc aagagattgc cggtattgtg 3667081 tcattgcctc atcaatgata ttgataccca aaaactgaat gcttatcaca aaatagaaga 3667141 caatactaag catataaata agagcgcccg aaataatggc gtgcccgggc tctttccttt 3667201 tgaaaaaatg tcccatggca atgccggcgc aagctgacat aaaagctaca ataagcccgt 3667261 taaaggaccc gacaataaaa acaaccggaa gactgacagc gcccatccat atccctagct 3667321 tcaatccatg tctgatcgta tacaagatca ttggcagcgg cagtgcaaat aacagaattg 3667381 ttccaatcac aggaacataa acgaccagaa gcgtaatgat cgcaaacaga ctgattaaaa 3667441 tagcaccttc cattaaagct ctcgtttgtt tcacttagtc acctcgtatc atcctgaaca 3667501 tacgaataga aaagagcagc ataaacgact gctcttttgt tcatcgctgc aacatgcttt 3667561 gcaccgaatg tttttatatc atctctaaat tttactttta tattttaaca taagtccaaa 3667621 tcgcaagtaa aatgacgcta atgtttcatg tgaaacatga aaaaggaaaa gacattcttt 3667681 gaaaagaatg cccatcacaa ttaatgttta tcatccataa agccagaaga ttccttgttt 3667741 ttctttttcg tttttctgac atacataaaa attaagatca ccagtaaaag ggttgttgct 3667801 tgcagaacgc cgctgctaaa caagaaaaag ttctttatca tgtcccacat tgtgtttcac 3667861 ctctttgtgc atgttctcaa cccgtatcct atataaggtg aatttccctt tttaaaaact 3667921 tcaaaacatc atgaacaaca ttgagcgttg ggcatatgct gatatggaat ctgatcgata 3667981 aaggagaatt ttcacatgga tgaacgcaga acattggctt ggcatgaaac attagaaatg 3668041 cacgagctgg ttgcttttca atcaaacgga ctcattaaac tgaagaaaat gataagagaa 3668101 gtaaaagacc ctcagctcag acagctttat aacgtgtcta ttcagggtgt tgagcaaaat 3668161 ttgagagagc ttcttccgtt ctttccacag gctccgcaca gagaggatga ggaagaagaa 3668221 cgcgcagata acccatttta cagcggtgac ctgctcggtt ttgccaaaac atctgtccgc 3668281 agctatgcca tcgcaattac agaaacagca acacctcaat taagaaacgt actggtcaaa 3668341 cagctgaatg ctgccatcca gctgcacgcc caagtttatc gatacatgta tcagcatgga 3668401 tattatccgt cttacaacct ttctgaactg ttgaaaaacg atgtcagaaa cgccaacaga 3668461 gccatttcaa tgaaataaaa caagcagcaa aggagttccc tttgctgcta tttctgctga 3668521 tccttcacta agccgttcga acgataagat tccagcacgt ctctgttgga ttctccccat 3668581 tctttcattt gcaaaacaat cggttcaagc gtgcgcccaa attccgtcag agagtactct 3668641 accttgggcg gcacctggtg ataaacctca cggtgcacga tgccgtccgc ttccagctcc 3668701 ctcagctgga gagtaagcat tctttgagta atactcgggc agattcgccg aaactcatta 3668761 aatcgtttct tgccatctat catgtgataa aaaagaattc ctttccactt tccgccaatg 3668821 acatctagag tgaattcaac tggacagcct tctttgttcg ggtatatatt ctttttttca 3668881 ctcattcttg accctccaat agtacctttt ttgatactac attacatttt gcaactaatc 3668941 tacccagtat tttacacacc ttttctcctt agctcaaaga aaatgcttct tattcacatc 3669001 aatttttaag ggtttgcatg attacacctg cagcaagacg tgttaaacta tataaagatt 3669061 acactactta aaaaaggata ggagctatca tggaaaagat acttattttc ggacaccaaa 3669121 acccagatac agatacgatt tgttctgcga ttgcttatgc tgatttgaaa aacaaactcg 3669181 gcttcaatgc tgagcctgtc cgcctcggac aagtcaacgg cgaaacacaa tacgcgcttg 3669241 actatttcaa acaagaaagc ccgcgtcttg ttgaaacagc tgcaaacgaa gtaaacggcg 3669301 ttatcctggt tgaccataac gaacgccagc aaagcatcaa agacattgaa gaggttcagg 3669361 ttttagaggt tatcgaccat caccgcatcg ctaactttga aacagctgag ccgctttact 3669421 atcgtgctga gcctgtaggc tgtacggcta ccatcttaaa caaaatgtac aaagagaata 3669481 acgtgaaaat cgagaaagaa attgccggcc ttatgctgtc tgcgatcatt tctgattccc 3669541 tgttatttaa atctccaact tgcacggacc aagacgtagc agcagcaaaa gagcttgcgg 3669601 agatcgctgg agtagatgct gaagaatacg gcttgaacat gttgaaagca ggcgctgatc 3669661 taagcaaaaa aacagtggaa gagctcattt ctcttgatgc gaaagaattt acactcggca 3669721 gcaagaaagt cgaaatcgca caagtaaaca cagtggacat tgaagatgta aaaaaacgcc 3669781 aagctgaatt agaagctgtg atctcaaaag ttgtggctga gaagaatctt gatctgttcc 3669841 ttctcgttat cacagatatc ttagaaaatg attcacttgc tcttgcaatc ggtaacgaag 3669901 cagcgaaagt ggaaaaagcg ttcaacgtta cattagaaaa caacacagcc ctcttaaaag 3669961 gcgttgtttc ccgtaaaaaa caagtcgttc ctgtcttaac agacgcaatg gctgaataag 3670021 caaaaagcat cccgcgtcgg gatgcttttt cttattcacc cagcttctca atttgtccca 3670081 tcacatcagt aatttgcttt gcgttttgga ccaggtctga ctgctccaat tctttaagcg 3670141 ataccttgcc ttcctcggct tgtttcaaca catcttcagc gcttttctgc aaggtttcgt 3670201 tatgctcctg aatggttcga tgaatctccg ctgcggcatc aggcggcgtt aattcattaa 3670261 aatcagcggc agccttctga atcgactcaa gctgcgcttc aagtttttct ttcgcctcgg 3670321 tgtcatttac agctttctca gccaattcag gcgcttcctc tgcaaatgtc ttcaccttct 3670381 ccacataacc agctgcttca ctcgtatagt tcaatccgtc gttcacctga tcaagcatgc 3670441 cgcatccgcc tgcactcaaa agtcccactc cggcaagtac tgtcaaaatg atcttcatct 3670501 tcagccccct catcgtttct ttttcatttt ttcttttaag atcggaatca atttctcttt 3670561 cgctaacggc agccctttcc tcaccaattc acgcttcagc cactttttca gcttagacat 3670621 tctgatgctc ctctcccttt ttgataaaaa tgaaaaaact ccaccaattt ggtgaagttc 3670681 ctgaaacaaa aagaccttca ccaaatcaga tttggcaaag gtctcgctaa caatgagatt 3670741 gccagcaaag ccgaggacac cttgtcccgt aatgacgact ttactgtgaa agctactccc 3670801 ctttggagtg ttcattttta ttactttcat tctaaagcac cgatctgttc cagtcaaatt 3670861 cctgccgttt atataaaagc gcgctgtggt atttaaaatt tgaatggttt ttctatcagg 3670921 agatcatgct atgacagagg aggttttcat catgagtcaa gagcgcgtga aacggcctgg 3670981 gcataccaga tggtacatat cttcgttact tagcggcatt attattctta attattttga 3671041 ccgagtggcc atctcggtag cggcccctgc gatacaagat tcgtttcacc ttactgcaac 3671101 tgaactcggc atcgtgtttt ccatttacac ctattcctat acactgatgc agctgcctgt 3671161 cggaagtttg ctggaccgtt ttggggtcgc atgggtcacg agggttggaa tgacaatatg 3671221 gagcttttta acgatccttc ttgctttttt gcaaggaaaa ttgctgttgt atctgttccg 3671281 gtttctcatt gggctgacga gcgcctctgc gttccctgct gcctctaaag caaccgctct 3671341 ctggtttcct ccaagtgagc ggggattggc aaactcactg ttcgattcgg ccgccaagtt 3671401 ttcaaatgta atcggcgcgc cattggtcgc ctttcttgtc acaacatttg actggcgtgt 3671461 cgcttttttg acgattggat gcatcaatgt gctgtttacg atctttttct ggcagtatta 3671521 tgaacagcct gaacggcaca aacgcatttc taaaagtgaa ctaaactata ttcaaaaaca 3671581 caatgccatt acaacagagc aaatccctta caaaacgggc ccgcttttaa aaaagctttt 3671641 caccaatcga aaagtatggg gcttaatgat cggatttaca gggtacgggt atacattcaa 3671701 cctgctgctc acctggcttc cgactttctt taaacataca tacggtatgg atctcatgtc 3671761 gtccggttta tttacggcag tgccgtggct gatctcaacc atttccggaa ttgccgtcgg 3671821 cggctggctc gtcgattatt ttattaagaa aggctatcct aataccaagg tgtaccgaac 3671881 cgtaatcata gtcggaatga gctttggctt tttcttttta ggatccattc tgacgaacaa 3671941 tattaccgta gccattattt gcatttccat cggactcgcc ggaatttccg caaccgctcc 3672001 ggtcggctgg tccatctccg cagaactcgc gccgatcggt tccgtatcca tgctgagctc 3672061 catggtgaat ctcgcaaaca acctgttcgg aggcattatt gctgcgtcac tgacagggta 3672121 tttgtttgat gtgacaggct cctttaccct cagctttctg gtagctggtt ttgtgctgtt 3672181 gctgggattg gttttttatg tgtttgtatt aggggatgta aaacgaatta aactatagaa 3672241 catgaaaaag agagctgcca gttggcagct ctccctttac atcaaagaat cggcccgtcc 3672301 ccatttacct tctcctcgtc ctgttcctct atatcaagcc ccgaagctag catttcctgc 3672361 tctatctgtt cgagcacctg ctcgtttttt ccttgaagac caccttcata atgaaaagca 3672421 tcctgtgtgc cgttttcctc tattgtcgct aaaatatcgt ggatatcatt atggtctcct 3672481 gaaatggagc cgaatccctg gttttgtttt ttataattca caaaaccgct ggggaggttg 3672541 tttccgaggt ttacacatga tgcgctccga gtagtaattc atcagtgtat caaaatcttc 3672601 attttggatt gccacatcac atgcagagat gatgtctttc aattgctgtt ccaaatgaat 3672661 tcccctaatc atcatgattg gatatattat acaatgtttg acacgtaggg atccttttca 3672721 tttttgtttt tacggtttcg ctggtccatt tccgcagagc tggcgccgat cggttccgta 3672781 tccatgctga gctccatggt aaatctggca aacaacctgt tcgaaggcat tattgcggct 3672841 tcattgacgg ggtattttgt ttgatgtgac aaggctcctt tacgctcagc tttctggtag 3672901 ccagttttgt tctgctgctt ggattggttt tttacgtgtt tgtcttaggg gatgtaaaac 3672961 gaattaagcg ggaataaaga gtgcttgtag agaaaacgtt gttctttcta caagcttttt 3673021 agttttgtgc tgtttttcaa gatattcagc tgtcataaaa agaaaatgag ctcccacata 3673081 ccggctaggt atgtggcgtt cttcttcatg ttctggcatg cagctgtgag gaggatttgt 3673141 ttgctcaccc cctgaacctg cgatagctaa gcccgtgcag ttgttttgaa cctacaaagc 3673201 ttcgttctat tttttctttt ctttttttag agatttcctg aaatagaaaa gcaatctttt 3673261 ctaacctttt ctttatggtt ttgccataca taccgagtaa cgactttctg gcgtttcgtt 3673321 gattttgtgt aatattctca aacatatttc aggatttgat ttatatgacc gatagtcttt 3673381 gcgatcaatt gttgagtacg taagtgtatg ctgattcaac aaatgtatct gtattgttca 3673441 ctttataatg aaatttccat tttggaagca aacccctgac tgggtgataa cgtctatgtg 3673501 cgatggcacc aaaaacttgg aggtcaaata gtcctttaga gatgagagtt gttaagtagc 3673561 cggaatctag agcgacggct tctacttgaa aatcaaatca tgcaatttag tgatccaatc 3673621 ggtcaaggta gggcttggaa cagaatcatg gacttttctg gagttgcaaa ctattaatcg 3673681 tcctcattaa atttataata aaaatattct caattgagca aatcgcccac cctttttcct 3673741 ttataacata aaatccaata ctatcaataa aattctttac aggttattac agttaagata 3673801 taatatagtt aatcttttac gtaaaaggag gtttttatta cttgtgttga agttttaaat 3673861 aggagtaact ccatctcccc attacggtct tcatttaatt tcatcctgag ttttatttag 3673921 ttagatataa aaacgaaaat ttcacattat ttttaactaa ccgatagtat aaaatatata 3673981 ttgaaaggat tgtaaaatta tgaataaatt cctgaagagc aatttccgtt tccttcttgc 3674041 ggctgcttta ggcatatcat tacttgctag tagtaatttt ataaaagcca gcaatgataa 3674101 ctataaattc catttacttg taccttatgg ctatggtaat gcctattcaa atgatgcatt 3674161 tagacagacc actcatacag ataatccttg gaaagtaaat ttacagaaat cggcagaagg 3674221 taaaggtaca atcatgacat tttggttgat taacacaggg aatagtaaaa ttccaaaagc 3674281 ttctaaaata cataacgtaa aacaaggaag cggagctcat tattatcatg caaatagcca 3674341 gggaagccat acatatgtag ccttagcagt tgaaaacaac aattacagtg caagttctta 3674401 tggtatagat ggtgtatggg atgaagaaac ttggtaaaca agaaccttct aaaaacgttg 3674461 gcacctttta gccacgcgaa aaaatttaga atgataatct ttttataaga ttatcatttt 3674521 tatttattct attaagaatt gagtgagaac atggaaagtc atatttatcg cattatcaaa 3674581 aataaattaa ctataataat atttactata atcatattaa ttccttgtgt tgatatatca 3674641 ctattgttaa tgactaacac agaataccat cctgcatatg cgtttttcct ttctggcact 3674701 tccgtagggc atgcttcaca aatgatccta ttatggtttc ttccgcttta ttttttgtta 3674761 ctatgtgctg acgattctat acaagattat aaaacaggat atcattacat tcttataagc 3674821 aaagttggca gaaaaaaata ttgtttggaa aaaatattta cctcttttat catttcattt 3674881 ttgacaatgt ttttgtcact aatattaaac tttttattgg ttcaggtttt cttttttaaa 3674941 ggtacattta aaaatgactt agaccaaatt aaattccctg ataacagcct ttatactttt 3675001 agtatggccc atccttatat agcaattgtg ttattttcta ttatttgttg tattatgtct 3675061 ggatttgttg gagcacttgg ttcaagcctc agtttacttt ttcgtgataa gaagtatgcc 3675121 tacccagcaa gtttttttat ttggttcgta cttatactaa aaaacaaatc attaatgttt 3675181 ttattccaac cgtttacaga atacggttat aatgtacttc tccctatcct atgtttgtct 3675241 atctttattt ttctaataat aatttctagt attgttttat atgaggcaaa atacaatgaa 3675301 aattaaaaga ctactattaa ttttatgttt actactattt ttagttactt tatggttcaa 3675361 ccagaaccac acttatcttg gaaagaattc tatcgcgtca ttactatata tgaataatag 3675421 tacattcgga tatagttcaa tatttgcata taccttgttt tatattgtcc cgtttcttat 3675481 gttacttagt aacttttttc attcagaaaa cccctacaaa gtaatgagga tggttaagcg 3675541 taaaaattac tacaagtcta aaattatgga gattgggttt gtttctttac ttttttcttc 3675601 aatacatact gttattaata ttacgtgtac acatattttc tttagtaaaa acttgttggt 3675661 cgaagcaaac tttttatcaa tttgtttatt aaacatgatt agtttagtgt ttttctactt 3675721 atcagtaggt attatgttta gacttacata cgatctgttt aattcagtag cattagcaat 3675781 ttttattgtg tatataattt tagatagctt gtatttcggc gttaaattat tacttcctaa 3675841 tggatattgg gaacccttta gagacttggc tatattcaca aatatgctca atagatattg 3675901 gtcaacttca aatcttataa tagtttatat tagacagata ataatagttt ttatttttta 3675961 tttagttgga tcttcaattt ttttgaataa ggattataaa aaatgaggat taaaggcttt 3676021 ttcataactt tagttgcgat aatatttcag gcgtcattat cgagttataa taataataaa 3676081 aatgtctttc cttttttaga tggcatacca ataagcacct cgggtcatta tgagtatcaa 3676141 aatattttat tgtggtttgt acctattgtt tccctaagtt tttgtttctc tgggagtatt 3676201 agagatacat acatttcgta tgagcaatta aagttagtaa gagaacatag tagagttaaa 3676261 tgggtaacat ctcaattctt aataattaca gttgtacttt taatctttac tttatctcag 3676321 attgctatat tttatattta ttcacttgta tctcttcata accttgatat taattccgtt 3676381 atcaataaaa gatttgttat gatgacactc atgtattatc taaccttact taacttattt 3676441 agttttcaat tatttatgga gctttattat aaatctcaaa tagcacaatt aaatataagc 3676501 gtttatatta ttttttcgtt aattttagca aagaagttag tgcaattaaa ttctccgaaa 3676561 gttattcact actttttaat tccaaactac agtaatggat taagaactgg gttaagctat 3676621 tattcccaat ctggaactgc tattattgaa ccattattag gtttgtttat tataatcatt 3676681 ttacagattt caatagttat attatctgtc ttaaagttca aaaaaataga tatgctaaaa 3676741 agtgagggct tacaatgatt gaggtattaa acctaacaaa aaaattaaaa agactacagt 3676801 tttagataat atctcttata catttgaaaa aggaacaatt tatggactat ttgggagtaa 3676861 tggttctgga aagaccatgc tacttcgtgc attatccggg ttaatagtcc ctactgaagg 3676921 gagtataact attaaaggtg aacaattaca taaagatatc tcttttccta aaagtgtagg 3676981 attaattata gaaaatatgc agttacttcc tcagtatgat gcttttacta accttaaaat 3677041 tttgtcaaaa attaaaaaga tcgcatcaga taatgatata ttagattcta ttagtagagt 3677101 tggtttggaa aattttaata gtgtaaaggt tagtaaattc tcgttaggaa tgaaacaacg 3677161 attaaatatt gcacaggcta tttttgaaaa acctgatata ttgctacttg atgaaccaac 3677221 aaatgcgatt gatgaaaaag gagttgcatt tgttcatgac attcttttac aagagaaaaa 3677281 aaggggagct accattatta ttactagtca tcacaaggaa gatattatat ctttatgtga 3677341 cattgcatta gaaatgaatc atggacgtct agaaacttca gaaaaagtaa tatataagaa 3677401 agatagttag tttaaactgg ctatttctta tccaatgata gactgcagac aagttcaact 3677461 gctgtaatgc tagaaaatcc aatgaaatgc tgataattgc gaagagatat gatcagtcag 3677521 aaaacaaatc ttaaaaagaa aaagtaaatt catcaatatt tctaataaac ctggcaaaca 3677581 acctgttcgg aggcattata gctacttcac tgacgggata tttatttgat gtgacaggct 3677641 ccttacgctc agctttctgg tgccggtttt gtgttgttgc tgggattggt tttttatgtg 3677701 tttgtattag gggatgtaaa acgaattaaa ctggaataaa gagtgcttgc tgaaaagcac 3677761 tctttttctg catcgaaaga atacttaaga taagtcactc ccaaaaatcg taacagtctg 3677821 acggttaaac ataaacctct gcccgttcca ttttaatacg gtttgaacat atcccaatga 3677881 gtcggcgtta taccttcccg ctatccgctg gtacgccaat aattcgtata cgccgtctct 3677941 gtcaaaatca accggataca agcccgataa aggattcacc catccttcta tcggcatttt 3678001 taacacacct tggctgttat aaatctcatt caaatattcc ctgcccttgt aagtaaggtc 3678061 gaggatatac gtttcgtttt gctgatgact gataacgctc gctttatatt gattttgata 3678121 cctcacactg tactttaatt catcattcaa tacatctgaa ttgaaaattc gccggaactg 3678181 cctgtttaga taggcaaaca catatgcata aatagcaccg ccgcttcccc ctgtgtccat 3678241 tactactgcc acatcctcaa tcttgtcgcc tgtcatatcc cccagaaaaa gtgacggatt 3678301 gtatcccata ttgttttgaa gctgaatccg ctgctcctga tgggttctgc catcacggat 3678361 caccaatgtg atatttctcc ataacgggct gccgggcatt tgatttccag ttagaaagac 3678421 ctcgtcaata acgccgtctc ccgttacatc gccgcgggta gatacaatga ttgcacgtga 3678481 ggagacaggc tgccgaaata cgtatggatg ttgaacaagt cctctgcctt cataaaacca 3678541 ataaggagcc attctgatgt catacacatt caattgtgtc accttcccta atcagctgaa 3678601 tgaatcatta tatgcaggaa tggcacatca aagacatatc ttacacacca attaaatccg 3678661 taccatatga attatcaatt acacaaagcc actcgccttg cgcattcttt ttaaatacat 3678721 aggtcgccct tctttccatc gcatactcgg agtccttttt atccgaatca agcagtgtct 3678781 gagaaagaac gagtaccgtg tcacctgctt ccaacaggat cattttccct tgtgtcggga 3678841 caatatgatg attgaaatag ttcgcaatcg tgataaacgc ttttttgatt tcttccttgc 3678901 ctcgcgcgat catgcccggc ttcacaacta aaacggcatc ttccgaataa taattcatca 3678961 gtgtatcaaa atcttcattt tggattgcca aatcacacgc agagatgatg tctttcaatt 3679021 gctgttccaa atgaattccc ccaatcatca tgattggata tattatacat cgctagacca 3679081 ctgaaacctt gaaaacaaaa tgaaaagtat ccttttttcc tatataatca aatagatata 3679141 tttaacaaag tacccaagtg aaggggtgaa cattattgtc tgcggaagta acgttacatg 3679201 acaatataca ttatgattta agtgcggatt gccagcactg ttttggcctg tgctgtgtcg 3679261 ccttgcctta tgcgaagtcg gcagattttg cttttgataa agacgggggc acgccttgcc 3679321 gcaacttaca atcaaactat caatgttcta tacataaaga tctcagagaa aaaggatttc 3679381 gaggctgctc tgcatatgaa tgctttggcg ccggccaaaa agtatcccaa atcacttatg 3679441 agggaaagga ttggcgaaac agccccgaaa cggccaacca gatgtttgac gtttttccta 3679501 tcatgcagca gctgcacgaa atgctctggt atttacatga agctctttct atagatatag 3679561 ccaagccgat tcattctgaa ctgagaacca ctttcgaaaa aatagaaagg ctcaccagac 3679621 tcagcaaaga acgcttgctg acactgcagg tggacgagca tcgagctgag gtcaatgaat 3679681 ggctgttaaa aacaagtgaa ctggtgcgtg cccaagcccg ccatccaaaa ctcccgaaaa 3679741 aggtcagccg gggaagtgtc ctgatcggcg cgaaactgaa agggcttgat ctgcgaggag 3679801 caaatctaag aggggcgctg ctcatagccg ccgatctgag aaatgccgat ttgagaatga 3679861 cagactttat cggtgcagat atgagagacg ctgatctcag cggcgccgac ctgaccggga 3679921 gcatcttttt gacacaggca caggtgaacg ccgccaacgg cgattcgaat acaaagctgc 3679981 cgctgtctgt acgaacccct gcccattgga aataaaaaag gacccgctaa cggtcctttt 3680041 ttactgatca attcaatcct ttttcgttcc tcttatccgg cattttcaca cttcttgcca 3680101 agtatcccga cagccataac gcaaccagca gcatgaaggt gatcataccg acgacgccca 3680161 gccagtgaaa accagaccag aatagccctc cgattgttcc gaaaacactt gaaccggcgt 3680221 aataaaagaa caaatacagc gatgaagcct gtgctttgtt gtgaagggct ctcctgccca 3680281 cccagctgct ggcaactgaa tgccctccga aaaaaccgaa tgtaaagagg gcaatcccca 3680341 gaattttcac tgccagcata ttgtttatcg taaataacgc acctgcaatg acgatgaaaa 3680401 tattcatcac caatattttc ggatagccat accgatcaac cattcttcca atgaaagacg 3680461 agctgaaaat gcctacaatc atcacaataa agatccagct ggaaaatgct ttattaagcg 3680521 aatacggcgg gcccaacagc acatacacaa tgtaattaaa caaggcaaca ttgcttccaa 3680581 gcagcaaaaa accaatgaga aacaagctga atagtttacg gtccctcaag tggccgatca 3680641 gagacattcc caatttcccg agcttcaatt ttcttggcgt aaaatgcctg gatggcggca 3680701 aatttataaa aaatataaca ctagcaatca aactaatgac accaattgtc cccatcgcca 3680761 tatgccaatt caagtactcg ctcaggagcc cggaaacgat ccttccgaaa acggcgccga 3680821 ttgcatttcc gctgatatat agccccatcg ctgatccaag acttccgggt tcaatttctt 3680881 ccccaagata agccatcgca atcgacggaa ggcctgcgag cgcaacgcct tgaatggttc 3680941 tcaatacgag cagtgtatga aagctcggac taaaggccga tgccagacag agaaccgatg 3681001 cggccagcat ggaaataccc ataataggct tgcgtcccca cacctcggat aatgaaccaa 3681061 agacaagcat gctcacagct aacagcattg tggtaacaga taaagaaaga ctcgccgcag 3681121 taggcgttac atgaaattcc cgcgtgaatt cctccatgag cggctgtacg caatatagaa 3681181 tcgcaaatgt attgaaaccc gcagcgaaga aagcaaacgt aatttttcga aaaaccggtg 3681241 tgccttttcg aatgtatgtc atcgggactt tatcggtccc tcatcatgtt gtggagcact 3681301 gccattcata aacaatcatc ctttatttct tacgaattca aacatcctcg agtctgttta 3681361 tattattatc ttagcaccgt tgatatatgt tgtataatgc atataaaata tccttttcat 3681421 gcttatatgt aataaggaga gatgataatt ggaatgggaa caacttgaat attttcaaac 3681481 actggcccgg atgcagcacg tcacgaaagc cgcaaaaagc ctctccatca cacagcctgc 3681541 actttcacgc tctatcgcca ggctggaaaa tcatttgggc gtcccgctat ttgacaggca 3681601 aggacgatcc atcagcttaa atcaatacgg acacattttt ttacgacggg ttcaggcgat 3681661 gatgaaggag tataccgaag gaaaagaaga aatccaagcc ttattaaagc cagaccaagg 3681721 cgtagtctct ctcggttttt tacatacatt aggcaccacg ctcgtgcccg atctcatcgg 3681781 ctcctttcag caggaatacc ccaacatttc cttccagctg aagcaaaacc actcttattg 3681841 gctgcttgaa cgattaaaat ccggagatct ggacctctgt ctcctcgctt cgattaagcc 3681901 tgaaaatccg atccaatgga tcaagctgtg gagtgaagaa ctctttgtat ttgtgccaaa 3681961 tgatcaccca ttagccagtc gcgaaagcat taccctgaat gagattgccg gggagcgttt 3682021 tattttattg aaaaagggct atgcgcttcg gatgacggtc gatgagctgt ttgagaaggc 3682081 caatatacag ccgaacatta tgtttgaagg agaagaagca actactgccg caggttttgt 3682141 ggcagccggt ctgggcatat ctattctccc agacctgaaa ggcttagacc aaagcaaaat 3682201 caccaaaatc cgcgtcagct ggccggaatg tcagcgtgtc ataggaattg cctggataaa 3682261 aggcaggttt ttatcaccgg ttgctgagac ctttaaacaa tatgtgatca gccatttttc 3682321 tgagtaggaa ggattcaagc atgaatgtca aaaaaatcac gtcagaacag gatttacata 3682381 cagcgtttga aatcagaaag gcagtatttg tagaggaaca aggctgtccc atttcggatg 3682441 aattcgatga gttcgataca ctccacggtg actgccagca catcctggct tatcatcaga 3682501 atgtacctgt tggcactgca cgtgtccgta tcgttggcca cacggggaaa ctggaacgaa 3682561 tctgcattct gaagtcttac cgcaaattcg gtttgggaaa agtgatcgtc gatgcattag 3682621 aacgtattgt aaaagaacaa ggcatttctg ccttcaaact gcacggccag acacaggcgg 3682681 caggctttta tgaaaagctc ggctatcgga ctgcatcaga agaatttatg ctggacggca 3682741 ttccgcatgt gctgatgaca aaacaagacg attctgcgct atagattgtt cacaaatttg 3682801 tcacttatga gcatgaacgg ttcattggta tactaatcac cgattatgga gagaaggaat 3682861 gattgtatgc cagcaaataa aaaagaaggc cttatatttg gcgtgatgat gtgctttgga 3682921 atggtttgcg tcatgtcgat ttacaatgcc atcatcaacc gagccatcta cgatttttca 3682981 ctgatgaccg tttttgaaat ggtcatcggt tttatgatcg ccctcctgtt agatttactg 3683041 ttagtgggcc ccctcgccaa gaagattgca ttccgcatgc cgttcgacaa gactaaaaaa 3683101 atttatgtca tccttgccat gtcaacttgt atggtgattg gcatggtact ttgtatgtct 3683161 gtgttcggtt tagtgacagc ggttctagca aatgggctga acggggacag cctcttcagt 3683221 gcttatctta tgattgtgtt gaaaaatttc atcctggcct atccgttgca attactgatt 3683281 atgggcccat tagtcagagg agttttcatg aaatttgtaa aaccaaagct cacagccgca 3683341 atttaaatag aaaaggagtg agcctgacac tcactccttt tgctcatgaa tcgaatgtaa 3683401 aacaagctcc gcaaaagcct ctgcggcagg cagctgccat tttttctttt tgggtgtgag 3683461 taaatcggat cgagggcttc accatgctgg agatttttca gcttatgttt ttcacttcca 3683521 ttaatcccta taccttacca catagttttt atacaattct tcgttataaa ggatttcttc 3683581 gccatgtgaa gagcaaatga gcgttggttt gatttgatct atgattgagc cgctgtcgat 3683641 gttctcattt atatcaacac tgaatcttct tataggtggg tgtaaatcct ccttacttgt 3683701 gataaaaagg tcgcccgtca atagcgtacg atcgatttta tgataataca caacatgccc 3683761 cggcgaatgg ccaggtgtta aatagtattt cagaggcaga tgagcaagcg tttgctccgt 3683821 cagcggctgt acaatatggg ctacccctgt gttctccact tcatttttgt tcggatatgg 3683881 ctcttcccca ttgatgtact ttagttcttt ctggtgcgca aaaatcggaa tatcaaatct 3683941 ctctaaccat tttgatgcac ccccgatatg atcactgtgg ccatgggtaa gcaaaatggc 3684001 ttttggattg ccgatcgcta acgctgccct aatttgagca tcagcaaaac gttctattcc 3684061 cgtatcaaca atataaacat catcaccatc tttgataaac caggtatgaa ccggaatacg 3684121 aagaggcaca tcaagctcaa attcacattg aaagacatgt tctgatagtt gtctcaaatt 3684181 cacgcaaacc atctcctgtg gaaatttttt gatagtttta aagaaaacag aagtgaacgg 3684241 actattttca cccacgctcg agctgactgg attcttgaga ggaaacgccg attttcgcca 3684301 gcatcagctc aacttgttaa cgttgtccat taataatccc ttttgttccc cttcttcaca 3684361 tattcccaat cacgttctat attcttcctc actctatgaa ggagtgcaga aatggtttcc 3684421 ttttcctctg aagtaaaacc ggacaaggcc acttccgtgg aatgttctcc ttctcttctt 3684481 aacaatggat ataccttttt ccctttctca gtcgggaaca gtttttttat ttttttattt 3684541 tgctcatccg gcagtttttg aataaatccc tgcatttcca gcttcttaat ggcccgcgcg 3684601 gccgttgtcc ggtccacttt tatcatttcc gccaattttt cttgaataat tcccggattt 3684661 tcgtatatac gcacgagata gagatactgc cctcttgtta agtctaaatc tttaaattcg 3684721 atgttgctta tggaatccaa cgctcttgct atcatgccga tctcacgcaa aatatcattc 3684781 attcctaaaa cccctcacgt atttttgttg caattacaac aaaaatgttt taaccttact 3684841 attataagac cacatgcgtg ctgtacagtc cagactaata tcagaaaagg attgattcat 3684901 aatgaatata aaaagaataa caactgaagc tgatttacat gaagctttaa agattagaag 3684961 aggcgttttc attgaggagc aacatgtgtc tgaagccgat gagttcgatg aatttgatac 3685021 gcttcaggaa caatgccagc atatcttggt atatcatgag aatcagcctg tcggcaccgg 3685081 acgcgcgcgc atcgttggcc atacagcaaa gctggaaaga atctgcatcc taaaacctta 3685141 ccgtaagtac ggattgggga agatcatcgt aagcgggtta gaggaaatca tgaaagaaaa 3685201 aggactgact tcatataagc tgcatggtca aacacaagcg gcaggctttt atcaaaaact 3685261 gggctaccag atttcttcac aggaatttat ggaggacggc atccctcacg tcttgatgac 3685321 aaaagaaata tcgcggaata taacatgaaa tatatgtatt acggaatagg catactcata 3685381 ttaagtttgg gcatttcctt aaccatacaa tcaggactgg gcacatcacc cttcgatgcc 3685441 cttttggttg gtctgtcaaa aaaaatcggt cttaccgtag gaagctggga ggtccttatt 3685501 tctgtgatcc tcttaatctg caacgctata ttaacgagaa aaaaacctat tttgctgggc 3685561 ttgattacag cattcattac tggaataggc attgacctat ggttgtttgt tgtaaaaaac 3685621 accatctatc taaactcgtt gttaagcaaa ctgatttgtt ttggaattgg tttggtgctc 3685681 atcggtcttg gaacagccat ctatcttcag acgaaattcg catcaacacc gatcgatcat 3685741 ttaacactta ttatccgaga tctctccaaa agaacaatat tgttttcaag gacattggta 3685801 tacgctcttt tcttagtatt agccatcatc tttaaaggcc ctatcggcat cggaactctt 3685861 ttaacggttt gtttgggagg aatgctcctt cacgttttta tgcctattgt ggaaagacat 3685921 ttcttatcaa agaatagaag aggttattaa gaaacctctt ctcgatccaa aaaacgaaac 3685981 gcaaaacaag ccccgtttcg ttgtcaattc tttatctctg gtactgttga ggttttataa 3686041 tcaattaaaa tttatagtac caaaaaatcg caatttcatt tgctgttgga aagttggaat 3686101 aaagcatcgt atcaaccgca cctattataa agtgatgttt ggcataaaaa tgacaagctg 3686161 aaatattaat atcttgggtt tcaagcataa gaccacaaaa atgattctcc tttgcccact 3686221 caatcgcttt atgtaataat gctgttccaa cacctttttt tctatagtct tttgccacgg 3686281 caatgtcctc tattagtgca tacccattcc agttagaacg gatcttaatc cggccaatgc 3686341 agttgttttc aagataatat aaaaaagccg ctttcccctc ttcttcaaca taactaacat 3686401 ccatgtcatc atcttcatat tgtttaaaat aaggtttaga aaatcgttcc tcagtatatg 3686461 tccaaacacc gttttcaaaa gcaggtatca ttctcccaaa aacaacgaaa ggttcgtttg 3686521 gtttattgaa atctttcata ttcaaatgag tcattttcat gatcatatca atctccgcca 3686581 atcgagataa tatttagtaa actcgtttcg atactattca acaacagctt ccaaaagtgt 3686641 actctttaag agaacagcat tagataaggc atccattacc ttatatattt cactatctta 3686701 atgaggtatt tcaacagagg cttgtggtac agtaaaaagg aatagaaaca agagaaaaga 3686761 agatgaacct atgcccacta acaataaact caatgagaaa tatcatactt ccttcaactc 3686821 gcccacaacc ctgttgacta gtatccgtgg agagaggaag ctttgacaca gcttctgcca 3686881 ttgatgacat ctctattgaa gtatccaaag gacaaccaag gatcgctctt tgactttttc 3686941 aagaagaaag tagagtgaat aaaggagtga ttgagtatgt taacaagaga agatatcttt 3687001 aaacacgtca aagaaaaata cggtacatcg cctgattacc cgtgggagaa atacccaaac 3687061 tatgcttctt tgagacatac atcaaacaaa aaatggtacg gtcttatcat gaatgttctc 3687121 ccagaaaaat taggcttgga tggtcatggc gaaatagata ttctaaatct aaaatgtccc 3687181 cctgaaataa gtgatcgctt aagaaacggg gaaaatatct tacccggata tcatatggat 3687241 aaggaacatt ggatttcaat tgttttagaa cggacagatc cagaaggcga aatctataac 3687301 ttaatcgagc agagctttca tttaaccaag tgaagataaa gagtgttcct gctaatcaag 3687361 ctgcgaagag tagtgggcac tttcatttta ggatactgtt cttcactctg tccacaaacg 3687421 caacttagtt catctggtgc gagagtggga gaagaatttc aaccaacttc ttatgtaaaa 3687481 ggatgaatag ttatgacaaa taacttaaaa cagagaagaa tcattttaga tttagcagtt 3687541 actttagatg gttttattga agggaaaaat ggagaagttg attggtgtat tatggaccct 3687601 gatatggggt ttactgattt tttaaatcaa attgatacta ttttatatgg tagaaaaagc 3687661 ttcgatttat ggggacaata cattccaaaa aatgaagacc ctgatacaga aaaggaactt 3687721 tggaaattgg ttcatagtaa aaagaaatat gttttttcca gaacacaaaa tgagattgat 3687781 aatcaagcca tatttataaa tgataatatt cttgaagaag taaataaatt gaagaaaaat 3687841 cctggtaaag acatctggct atatggtgga gcgagtctca ttacaacttt tataaatttg 3687901 gggcttgttg atgaatttag attatctatt caccctgttg ttttgggaga aggaaaaccg 3687961 ttgtttattg atgtaaaaca gaggataaat ttaaaaatgg tgaatacaag aacattttcc 3688021 tctggcgttg tgcaaatcgt ttatcattgg aatggctaac attgtaaagt aacactcgac 3688081 agtaatcctt cttattgaac taaaggggaa tccataaata atgggttccc cttaatatac 3688141 tatggaatta tcaatatcaa attttctgta ataaaagagg attgaaaagg acgatgtctc 3688201 ctcaattaac atcattaagc attatagtat attttcttct ccctctttta agtaatcggc 3688261 taagttttgt atttataaaa aaacgaaaga aggtgatcca atgcctacta acaataaacc 3688321 caatagatta atcgctgaga aatctactta ttttacttca acatgctcat aaccctgtgg 3688381 actggttccc ttggggagaa gaagcatatg aaaaagcgaa acgcgaaaac aagcctgttc 3688441 tcgtatctat tgggtatagc taacgatggc taatctaaag aacatgctat tgatgccatg 3688501 tttattcatt ttacaaaaaa ggatcaacct tgaattactt tcacaagatt gatcctttca 3688561 ctcatttagc catgtctccg cgaacgttta tatacattca agattactag ccaacaaata 3688621 acaatgattc ctgcaaaaag tatgagcata ttgctataca aataggtaga gtgatcaacg 3688681 tcaataggca gcagcctatg atctaggaag ccgatagata ataaaccgcc tacaatcgca 3688741 atacccgttc cctctgataa aaagctcgtg aaattaagca aactcattcc agcgcccgct 3688801 tccttttctt tcaaactgct agacacaact gtagatataa ctgtttttgt gaaagatagc 3688861 cccccaaaaa caaaaattac tataattgtc atgatccatg gtgctgcatc tataaaaaag 3688921 gcagcgatta aaaagccgga agaaagcaat gcacttccaa tagttagtac atacaaggaa 3688981 cctttccgat caacaagcaa tcccccaatg taaccaaaga tgatgacact cattgttccg 3689041 gggaaaataa tgccgcttcc aattgctgca gtacttaaat ggtgaacatc tttcatcatg 3689101 taaggaacca tagagacaaa tcctgctact gtaccaaata ttagtcctcc gcaaagggtt 3689161 ccaatcacaa aaaagacgtt tttccctaat tcagggtcaa caaaagggtc ctgagctttc 3689221 ctaatgtgtt gcacaaatat gaagaaagca aggatactga tgatcagaaa agaaaatcta 3689281 taagatgttg taaacagcat aaaaaatacg atacctgcag acatcaatat aatccctgcc 3689341 atatcaatgt gtcctcttat tctctcttcc tttttcaaca attttataag gaatggaacg 3689401 gtgataattg ttgcagttgg aataagcagc aaatacgacc aatggatata atgagcaacc 3689461 attccgccaa tagctggccc aacaccttct cccattgcta ccagggaccc gatcaggcca 3689521 aatgctttcc ccctgttctc ttttggaata tagcgcgcaa cgacaaccat cacaagagct 3689581 gggaatgcgg ctgcaccaat tccttgaata aatcgggcta gaatgagaat aggaaagaaa 3689641 gagtgtccaa caaatccaat gatcgaccct aagccattta ccataatccc aaatagaagc 3689701 agatttttga tgcccagctg gtctgatagc tttccatata gagctgttcc aatggagaag 3689761 gttaacataa aggctgtatt cacccagttt gcacttgctg gcagtttatt aaactcgttg 3689821 gcaatatcag gtaatgagac gttcagaacc atttcattta atacgctgaa aaatgataga 3689881 acacaaagcc aaatcaaaac ttgattgtgc cgtaaagttg actgtgaata agacgtattc 3689941 acaatttccc ctccattaat gagggcagac gcagtttata gggtcattga tacgcttccc 3690001 tcttttaatt gtaccctgtt cattttattg cacttcataa taactccccc tacatttgat 3690061 tgatatgatc ttattatata tagactaagg attaaacttt tacttttttt ataaaaattt 3690121 gaccagattg cgaaacaagg aaaaacgtta ttcgcattta tctcaagtgg caaaatgaaa 3690181 cattagttta tattttcaca tcacaattat cgataagcag tcagttattg tatttgttta 3690241 ggataactgt ggtaacctga atataaccaa cttaggaaga aggtgatccc atgccaaata 3690301 aaagtaaacc caatagatta atcgctgaaa agtctcctta tttactccaa cacgcccaca 3690361 accctgtgga ctggttcccg tggggagaag aagcatttgc aaaagcaaaa cgcgaaaaca 3690421 agccggttct ggtcagcatc ggttattcga cgacttgtca ttggtggcct gggataatca 3690481 aatcgtgtgg aactccatta aaagataaca gaagccattt taaacgataa tactatttgt 3690541 tcaaacaata cagtctacct tttatttcat tcattttcta aaacctgtaa tccgtaacca 3690601 cgcggtagca ggttttttta tttgcttgac ttagagttaa ctctaaattg taaactaact 3690661 ttaattaaat gagagggatg atgttgttgt attccattag taaagctgct gagaagacta 3690721 gtattagttc gtatacatta agatattacg aaaagattgg gttacttcca ccaccaaaac 3690781 gaaaaaacag tggaaggcgt ttttatacgg agactgatat tcagttcatg ttattcctga 3690841 aaagtttaaa ggaaacaggt atgtctttgg aggatattaa tgagtttgtc aaagacggat 3690901 gcattttgga aaaaatcaat tcggatgtta aatcggcaca actctcccca tctataaata 3690961 aacgtattga gattttaacc aagcacttag agaaaatgga aattaaaaaa agggagctgg 3691021 aagaagtgat ttctactaca aaaggaaaac tggatacata ttattcaatt ttgaaagagg 3691081 aagtggaaaa caaatgaaac atttaaatat atacataatg ttacttggct tctctatttt 3691141 cacgggagct acttttaatc ttgcaaaata tacagttgga tatttttctc catcgtcttc 3691201 tgcggcatgg cgtttcggtt tagcggctgc agtgatgctc atcattttga tttttactga 3691261 aggtataaag aagagtcaat tacggaaaaa cgccgtttca tacattgttc ttggaattat 3691321 aggaatcttt ggatttaatg ccttgttttt tgttggttta aaatatacat ctcccgttaa 3691381 cggagcatta ataatggggc tgaatccttt attaacagca attctcgctc gaattatctt 3691441 aaaggacaac atgacaaaaa aacaagtact cggcatattc tttgcattca tcggtgtatt 3691501 gttagtcatt acacaaggtt ctatcgaaac cattaaaacc ttatcaattt caggaggaga 3691561 cttaataatc tttacaggta acgtttgttg ggcactttat ggcgtacttg gacgtcggtt 3691621 tgtaaaggat ggtacaccgc tatctacaac cacttatacg atggttattg gtgctgttag 3691681 tttaatagta gtttccttat ttacatccaa acctgtttct ttatcgaaca tcccgattgg 3691741 agtttggggg gcaattgctt ttatggcttt ttttacaagt gttttgggtt acctatggtg 3691801 gaatcagggg attaaagaga ttggagctag taaaacatct ttatttttca accttgttcc 3691861 cgttgtaacg atgattattt catttgccgt tggaacacca ataaaggtat ttcaagttat 3691921 tggggctgtg ctagttatat taggcgtttt aaccgcttcg ggggtaatac gtattcctaa 3691981 gtacaatact aaagaacagt cagctatata aagaaatagg gagtattttt gagaaaatgt 3692041 gttaagttaa atatacacta attataggaa gaaggtgatc ccatgccaaa caaaagtaaa 3692101 cccaatagat taatcaatga gaaatcacca tatttactcc aacacgccca caaccctgtg 3692161 gactggttcc cgtggggaga agaagctttt gaaaaagcaa aacgcgaaaa caagccggtt 3692221 ctggtcagca tcggttattc gacttgtcat tggtgccacg tgatggccca cgaaagcttt 3692281 gaagacgaag aaatcgcgcg tcttctcaat gaacggtttg tggcgattaa agtcgaccgg 3692341 gaagagcggc ctgatgtgga ttctgtttat atgagaatct gccagctgat gaccgggcag 3692401 ggcggctggc cgctgaatgt gtttatcacg cctgatcaaa agccgtttta cgcgggtaca 3692461 tattttccaa agacgagcaa attcaatcgt cccggttttg ttgatgtgct tgagcatctg 3692521 tctgagacgt ttgcgaacga ccgcgagcat gtcgaggata ttgcggagaa cgccgctaaa 3692581 catttgcaga ccaaaacagc tgcaaaaact ggtgagggcc ttagcgaatc agcgattcac 3692641 cggacattcc agcagcttgc cagcgggttt gacacgatct acggcggttt cgggcaggca 3692701 ccgaaatttc caatgcctca tatgctgatg tatttgctac gttatgatca caatacaggg 3692761 caggagaacg ctctatacaa cgtgacgaaa acattggaca gcatggcgaa tggcggcatt 3692821 tacgatcata tcggctatgg gttcgcccgc tattcgaccg atgacgagtg gctcgttccc 3692881 cactttgaaa aaatgctgta cgacaatgcg ctgctgctga ccgcttatac agaagcctat 3692941 caggtcacgc aaaacagccg ctataaagag atttgtgagc agatcattac gttcattcag 3693001 agggaaatga ctcatgaaga cggaagcttt ttctcggctt tggacgcgga cacagaagga 3693061 gaagaaggaa agtactacgt gtggtcaaag gaagagattc taaaaacgct cggggacgat 3693121 ctcggaacgc tgtattgcca agtgtatgac atcactgaag aaggaaactt tgaaggcaaa 3693181 aatattccta acctcattca cacaaagcga gaacaaatca aagaggatgc cgggttaacc 3693241 gaaaaagagc tcagtctcaa actcgaagac gcaagacagc agctcttgaa gacacgcgag 3693301 gaaagaacct atccgcatgt cgatgataaa gtgcttacct catggaacgc gctgatgatc 3693361 gcgggtcttg cgaaagcggc aaaggtatac caggagccga aatatctcag cctagcgaaa 3693421 gacgccatca catttattga aaacaaatta atcatcgacg gccgtgtgat ggtccgatat 3693481 cgtgatggcg aagtgaaaaa caaaggcttt atcgacgatt acgcttttct cctatgggct 3693541 tatctggatc tctatgaagc ttcgtttgat ctttcttatt tacaaaaagc gaagaaactg 3693601 acagacgata tgatcagctt attttgggat gaggagcatg gcggattcta cttcaccgga 3693661 cacgatgcag aagccttaat cgtacgggaa aaagaagtgt acgacggcgc cgtgccttca 3693721 ggaaacagtg tggcagctgt tcagctgctg cgtctcgggc aagtcacagg cgacttatca 3693781 ctgatcgaaa aagcggaaac aatgttttcc gtgttcaagc cagacataga agcgtatccg 3693841 agcggccatg ctttctttat gcaaagtgtg ttaaggcatc tgatgcctaa aaaagaaatc 3693901 gtgatttttg gcagcgcaga cgatccagcc agaaaacaaa ttatagcgga gcttcaaaaa 3693961 gcctttaagc ccaacgactc cattctggtg gcagagcagc ccgagcaatg caaagacatt 3694021 gcgccatttg cagcagacta ccgcatcata gacggcaaaa caaccgttta tatttgtgaa 3694081 aacttcgcct gccagcaacc gacaacaaat attgaagaag cgatccacac attaataagc 3694141 agcagggatt aagacccttg ctgcttactt tttgatttct tatggtacca taaagcgatc 3694201 cccgcaaaca caaggttgac cgctatcgta aagaaagcct cccacatcgg gttcccccgc 3694261 gtaacggtaa acagagaagg aattcctcca tacacactgt ttttttctgt aataaacata 3694321 cacaaaaaca tattattcgc ggcatgggcg ccaagtgata tttcgatgct cccagtttta 3694381 atcgtgtaat acgtccacac aaacccaaat gttaagtact caattcctgc ccagacagcg 3694441 ccattgttca tttctggatt cgcaaaatgc aatacgccaa acaatcctcc gacaatcagt 3694501 gtcaaaaata gaggattttt cgtcaatctc ccgaaagctt gaagcaaaaa tcccctgaaa 3694561 aatagttcct cagctgatgt ctgaatcgga accaaaatga gggcagccgc tagcagccag 3694621 ataaatcgtg atgcattaaa ctcttgcatt gaatagctat caggatgaat cacaaaatca 3694681 atcaattgta cggcgatcat tagcaagaaa taagcaataa aaccaaagga aattctccgc 3694741 caattcatct ttgaatttgg tgttatcacc gttcggaaag gccgcttcaa aataaagcgc 3694801 acagccagcc aaactcccgg aatggcgaat aaataaatca catgggacaa ataaagatct 3694861 acgaggggat cactcagcac agcttcatcc aaatcaaacg tgatattggg attcacaata 3694921 accgtgaaca atatagcgaa aaggtaagct atattcccta atacatataa ccctaccatc 3694981 accaaaaaag cgaaaaaata tctccacaac gtattgtttc cttctatagg acggataaat 3695041 gaattcattc cttctatgtc tcttcctttc aatgagaata ttactatata tttgcataaa 3695101 ttggtctatg aatctactgt tttggaaatc ttttaagcaa aattaaaata taaagtgtga 3695161 atttagttct tccatctagt gatttgaact ctgttgccaa tgaaccaaga tacttataat 3695221 agtcccaaga ggggaatttt cagtcttttc tactactcaa aagggggttt tttatgaata 3695281 cgatcttcaa acaaaagaat acacatcctt tctcaaacgc agcgaatcgt ttagaccgcc 3695341 ttccgatttc acgcgttcat ttccaagtgt taaccgctct cggcattgtt tatttctttg 3695401 atctcgcaga tttatttacc ctcagcaacg tagcgccggc actgatcgag cattggggca 3695461 tcccgctttc aactattgct aacgtaacgg ccgcttcgtt tttaggcatg tttttaggcg 3695521 cttcactggg cggacggctg tccgatcgaa tcggccgcaa aaaagcctta aatctatttg 3695581 tctttgtttt ctcaatcgca tcgctatgca atgctgcggc atgggacatt ccatctttaa 3695641 tgacattccg tttcctcacc ggatttggcg ttgcagccgc catggtcatt acgaatagct 3695701 atttggcgga atttttccct tcaagtgtac gtggaaaata tatttctttt tgtgccatga 3695761 ttggattgat tggggttccg atcaccaaca ttgtgtctgc ctttgtcatt cctcttggtt 3695821 catggggatg gaggctagta tttgtatggg gtgccgtcgg ccttatttat tttttcttca 3695881 tccaccgtct ggaagagtca cctcgctggc acgaaaatcg cggggaatat gcgaaagccg 3695941 atgcgatcct cacccgaatt gaagaacagg ttgaaaagga gaaaggcccg cttccggcag 3696001 catcccagcc taaagtaagc gaaactgtta agcagaatgc aggttacgca ggcttattga 3696061 aaggcagaaa cctcaaaatt accatcgtat tatctgctgt atggattttt gaaacgtttg 3696121 ggttttacgg atttgcttca tgggttccaa gcctgctaaa aagcaatggc gtaaccatgg 3696181 aaaatacatt atggtataac gtattgcatt ccgtcggcgc tccacttggc gcactgctcg 3696241 gctccatgat ttccgaaaga tttcaaagaa aatggatttt agctgcgagt gcgtttctga 3696301 cggccatcgc cgggctctta tatggtatga cttttattcc catcatgatc attgtatttg 3696361 gttttatcgt gaatatcaca gaacgggtct ttacctcgaa cttatacgcc tatacatctg 3696421 aaccttatcc gactgaatac cgctcgtctg gcagcggttt agcctatggt cttggccgtt 3696481 tttcaaacat ttttggctca ttgcttgtcg gatttattgc cgttcagctc ggctatatca 3696541 gcgtcttctt atttattggg ggctgttggc tcgcatgctc cttgctgtta atcttcttcg 3696601 gtcctaatac gaatgcaaaa cagatttaaa aaagtcagtg cggatctgcc gcactgatct 3696661 cattacaatt gcttcaaaat ccttgcgggg tttccgccta caacagtatt agcgggtaca 3696721 tccttagtga caacagatcc agaagcaatc actgcgttat caccgattgt cactcccggg 3696781 ttaatcaccg cccggcctcc aatccaaact tgatctccaa ttgtcacagg cttaccgaac 3696841 tccttcccgg atttcctttc gatcggatca agaggatgac cggccgtgta gatatgtaca 3696901 cctggcgcaa tcaaacaatg acagccgata cgcacctcac acacatctaa aatgacacag 3696961 tcaaaattaa caaatgtatg atctccgata tgaatgtgat agccataatc acagcggaat 3697021 gtcggcaaaa tcgtgacttg atccccaacc gaaccgagca gctccttcaa aagcttcgtc 3697081 cgcactgcat catcttccgg tgtttcgttg tattgtctaa tcagctgtct cgcatgcttg 3697141 cgttctagta atagttgttg atcttccgaa ttgtataatt ctccggctgc cattttttct 3697201 ttttctgtcc tcagcattta agtcactcca gatgtcagat tgtaatctcg atcaaatttc 3697261 cttcatcatc ctcaatcacg ctttcatagt agccgtctcc tgttgtcctc gggccgttta 3697321 ctactgcgaa accatccgcc ttcaatcgat cagtcagttc gtcaactttc tcccggctcc 3697381 caacggaaaa ggcaatatgt gcccagcctg tcattgtttg tgagggcgga tcggtcacat 3697441 tccctttttt cataatttcc agccttgctc cggaatcaaa cgtaataaaa taagacttaa 3697501 aatctttttt ctcattatga tacaaatcat tcgcttcgcc attaaaatac gattcataaa 3697561 aagacttcat tcgctctaaa tcattgaccc agaccgctgt atgttcaatc tgcatttctt 3697621 cctcctcctt cgccttcaat gaagttataa ggtatgaaat gcatttcagt tcaagctttt 3697681 ttcttaaatt tatgctgaat tttgatatca gcgggttcat cctgcaaaaa tagagaaaat 3697741 gctgcgatgc cgagctgctc aagattcaaa tcaagcgacg gaaaaccaag aacacggctg 3697801 atagaagtat ttccctcgcc tatgatttca acatcccaat tattcttttt ggcaaataga 3697861 tgaattccag ctgccacttc atcactattt gcataaatag cagtcggaac ccgcccgctc 3697921 atataaaaat gttcagctgc cagctcacca tcattcatat cgttgcatcc ggacagcata 3697981 tggcggtctt ccaaccttcc gcagacagct ttataggccg cagctttatc agccgtgctc 3698041 gggctcctat cagcttctct gacacacgta aaagcaatat tctcatgccc gcggctcttt 3698101 aaatagcgaa agctctctgc ataagcagtt tttctgtcat taaaagcaca agggacatca 3698161 atgtctccgg tatcctcaca agcgatgacc ggcccatatt cctgataagc taaaatgctg 3698221 tcccaatgat tggcgcggga agtaatgatg agaccgtcta ttttcttcgt tcttaacagc 3698281 tctaaatatt tgatttcaat atcggggtta taattggtgg ggagaagggt cgttgcatac 3698341 tcatgctgaa aagccgcctt ggtgattccg ttaacgattt tatcaaagca gggatgatcg 3698401 ctataaggca gaatcacacc gaccgtatgg gttttcccgc gaatgagatc gattgcggtt 3698461 cgatttggtg tataatccaa ttccttcatg acttgatgaa caagctttct cttttcttca 3698521 gatacatacg gatgatgatt caatacacgc gagacagtcg aaacagatac atttgccagt 3698581 cttgcgatct cttttatatt tgccatctct ttctcctttt catataaaaa aagcagtaag 3698641 tgtaaaatcc ttactgctat ctcatcatat attgatgata agttcaacag gacaatggtc 3698701 ggaacccatg acgtccgctg atatgctggc atcttcaatc tgttccttaa ggctttcaga 3698761 aacaacaaaa taatcaatcc gccatccaat atttctgtcc cgggcgccgg cacgatacga 3698821 ccaccaggaa taagcgcctt caagatcagg ataaacatga cgaaaagaat caacaaagcc 3698881 agcttctaag aaacgagtga atgcctctct ttcttgatct gaaaatccag cgttattccg 3698941 gttcgccttt ggatttttca agtcaatctc ctgatgggct acattcaaat caccgcataa 3699001 aatcactggt tttttctgat ccaattcaag aatataagac agtaaagcct cttcccattg 3699061 catgcggtaa tcaatccgct ctaatcccct tctggaattg ggcgtgtaaa cagtcatcac 3699121 aaacacgttt tcaaattcca gcgtaatcac tctgccttct tggtcatgct cttctactcc 3699181 gataccgtag atgacctgca gcggttcttg cttagaaaaa acagctgtgc cggaatatcc 3699241 ttttttcact gcataattcc agtacacatg atagtcttca ggctggagat caacctggcc 3699301 gtcctgtatc ttcgtttcct gaagacatat aatatctgca tcctcttctt tcaaataaga 3699361 gaggaaatcc atttttctca tcacagcccg caggccgttt acattccatg aaatcaactt 3699421 catgtttcat cctcccccct ataaaaaaga gcaagaaccc gaaggtcctt gctctttaca 3699481 tatcagctta ctcaccgctt acgtatggaa gtaaagccat ttgacgtgcg cgtttgatcg 3699541 ctgcagtcaa tttacgttgg tatttagcgt ttgttccagt tacacgacgt ggtaaaattt 3699601 taccgcgctc agaaacaaac tttttaagaa gatctacatc tttgtagtcg atgtgcgtga 3699661 taccgttaga agtgaaataa cacactttac ggcgtttcgc acgaccgcct ctgcgtcctc 3699721 ctgccattgt catttccctc ctttcttttt cattttaggc gataatcaca ttagaatgga 3699781 agatcatcat ccgagatgtc aatcggtttg ccgtcgttgg caaatgggtc atcattaaag 3699841 ctgttcccct gattgcgtct ctggttgttt tgatttcccc caaatggatt atcattttgg 3699901 cctccgccaa agtactggcc tccgccgctg tttccttcgt tgtatccacc tgaaccagaa 3699961 ccgccgccgt ttttcggctc aagaaattga acactttcag cttggacctc tgtcacgaag 3700021 acacgctgtc cttgctggtt ttcatagttt cttgtttgta aacggccatc tacgcctgca 3700081 aggcttcctt ttttcaagaa gtttgcaacg ttttcggctt gtcttctcca agtgacacaa 3700141 ttaatgaaat cggcctcacg ttctccggac tggttcgtaa atgtacgatt cacagcaaga 3700201 gtaaacgtag caacagccgc accgtttggc gtataacgaa gctctgggtc ttttgtcagt 3700261 cttccgacta atacaactcg gttaagcata agaaagacca ccttttacca ttatatattt 3700321 caaaattgct tattcttctt ctttaacaac aatgtggcga atgatatcgt cactgatctt 3700381 agctagacgg tcaaattctt gaactgccgc agcgtcagat tgaacgttta cgatttggta 3700441 gaaaccgtcg cggaaatcgt tgatttcgta agcaagacga cgtttacccc aatcctttgt 3700501 tccagtgatc tccgcaccgt tagaagtcag aacgttgttg aaacgctcga taactgcttt 3700561 tttagactct tcgtcaatgt ttgggcggat aatgtacata acttcgtact ttctcatctg 3700621 tttgcacctc cttttggact aagcggccca taatgggcaa ggagcaataa ttctattact 3700681 cacaatttta tattatacca aagctcttgt ccctttacaa ctgcatccta tacattaaat 3700741 cggaaatgaa taacatctcc gtcttggacc acatattctt tcccttcaag gcggactttt 3700801 cctgcctctt tagctcctgc cataccgccg cccgcaagaa gatcctcata agcaactgtc 3700861 tcagcacgaa tgaagccccg ctcaaagtca ctatgaataa ttcctgcaca ctcaggggct 3700921 ttcatgcctt ttttgaatgt ccaagctctg acttcctgtt ctccggctgt gaaatatgtt 3700981 gcgaggccga gaagagagta agacgctttg atcagctgat caagacctga ttcttgaatg 3701041 cccagctctt ccaagaacat ttgcttttct tcgccttcaa gctcagcgat ttcagattcg 3701101 atttttgcac acacaacgat aacttctgcg ttttcgccgg cagcgtactc gcgaatcttc 3701161 gctacatttt cattgccaga tggatcagca acttcatctt cacttacgtt ggccacgtac 3701221 aaaataggct tcgaagtcag taaatggagc tgcttcacaa gcttttgctg ctcttcagtg 3701281 aattctacag atcgagcagg cttttcactc tcaaacgctt ctttcagttt agataaaatc 3701341 tcaaactcaa atacagcgtc tttatctttt tgcttcgcaa gcttgctgac gcgtgtaatc 3701401 cgcttttcaa ctgtttccat atcagcgagg atcagctcaa ggttgatcgt ttcaatgtca 3701461 tcaatcggat caacctttcc ggaaacgtgt gtaatgttgt catcggaaaa agcacggaca 3701521 acgtggcaaa tcgcgtcaac ttggcgaata tgagatagga acttgttgcc gagtccttct 3701581 cctttagatg cgccctttac aatccctgca atatcagtga attcaaaagc agtcggcaca 3701641 gtcttcttcg ggttgaccag ctcagtcagc ttttgcagac gatcatccgg cacctctaca 3701701 attcccacgt tcggatcaat tgtacagaac gggtagttgg ctgattcggc accggcctgt 3701761 gtaattgcgt taaatagtgt tgattttccg acgttcggca aaccaacaat tccagctgtt 3701821 aaagccattc tttcatctcc tctatataaa accgtcattg tatgaacgta ttttgaacct 3701881 agagcaatta taaggaggtt cactggaaaa gacaagctga caaaaaagca ttttcagctt 3701941 gccaatccct ttgattatgc ttttttcaag cctactaaac agtcaaaaag cgtacttccc 3702001 attccattat cagaatttgt atcatttgtc agtgcattga ctgaccctcc aaaagccgcc 3702061 cacatgcctt catctatatt aatcgtcttc gcatgagcct gcttcatcac tttcaccttg 3702121 cccttcatgc ttccgcggtc attaaagatg acaacttcgt ctccatcctg aagatcctgc 3702181 ccagccgcta tatctggaga aatatcgacc tgaacgtgct gaagcttttc aataaacggc 3702241 acatgctgtg aatgattgga acgctgcgga tgaatggata agagcgtata agggtacttt 3702301 ccagctaact cctcattatg gaaaacagat tcttcgggca catttaattg aagcgagccg 3702361 ctaaatcctt tttgctcagc tagcgacgaa gtaaattcaa attttccact cggcgtcaaa 3702421 aactgataat catcccacgg cacctgtttt actggaagag ggaggtggcc tttttctttt 3702481 aaacgctcaa gtgtcacatc ctctgcttcc aatgaagaaa gccccatctc taaaaattct 3702541 tgagtgctgt attcaaacag ctcgccaaac ccaagacgtt ttgcaagctc tgaccagatc 3702601 cagctgtccg atttcgcttc accctgcggc tccacaagct tcttcccgta ctgaacataa 3702661 tgatgataca tactggaata gtagatatct tcttcttcaa aaacagtggc agtcggcaaa 3702721 acataatcac acagctctgc ggtatccgtc ataatggaat caatcgcgac cgtcattgga 3702781 accttttcaa atgcttgtct caccttattt gtattcggca cctgagtcag cggatttccg 3702841 cacgtcacaa taatcatctc aatcgcagga tcagcagcgg tcaacacttc ttcagcctgt 3702901 gtcatcattg aaaaagaacg ggatgttgtt tttaattccg gcagcgtcag ctttgttttt 3702961 gcaaagctct caccaatctg gacatttccg aaattcgcgc cgccgccctt aattccgaca 3703021 tttccgcttg ccgccacaag tgcatcaatc caacgaatcg ttcccccgcc gtttttatat 3703081 cgctgcatgc caagccccat aaaagtagac accggaccat cagcatacaa acctgccaaa 3703141 tactccagct cctccataga agtttctgtt ttcacaataa actcttccag agaaacggtc 3703201 ttcaaaagct ctttcacatc atcaaaaccg acagaatgct cagaaataaa cgtttcatcc 3703261 gttcttccca tctcaatcag aaccttcaaa acggctgccg caagccagcc gtccattcca 3703321 ggctttacag agatatagcg gtcggcaagc ttagcagtcg ggttgaagat cggatcaatc 3703381 accgtaatcg tggcgccctt ctttttcacc tgctgcaagt gatggtataa gtgcatattt 3703441 gttcttgata catttcttcc ccacacaaca acatgcttgc tgttgtaaat atcaagcggt 3703501 ccgtgaccgt acgaacggcc aaaatcccag ctttgcgcct cgataccgga gccccagcat 3703561 atgcttccga cgatttcggt cacgccgcca tatccattaa aaaaacgctg atcaagcgct 3703621 tttaacagac cgttattcgc ataatcatgg ctgtgcaaaa cagcagtcgt ctccgacgtt 3703681 tccttgattt cccgaagttt atcggcaatt tcatcaagtg cctgctccca agaaatccgc 3703741 acaaactcgc cattttgttt tttcattgga tagcgaagcc gatcaggcga atttgttttt 3703801 gtctcaagca ttctgccgcg gccgcagatt ttaccttccg taatcggatg gtttggatct 3703861 ccgtccactt ttgttacctt tccatcatca acagtcacca aaaagccgca gctgtcccaa 3703921 caattcagcg gacatgccga ctgatgcact ttgctcatcg ccgtcttctc cttaccttct 3703981 atatgaaaaa gcatgagtgt cggcctattt atgaagtagg ctcctcatgc ttgactagta 3704041 ctttttttag ttttctttca aattctcttc tcggaatcat aacactgtga gagcatccct 3704101 cacacttaat tcgaatatcc attcccatgc gtataatttt ccagctgttc gctccgcatg 3704161 gatgcggttt tttcatttct acgatatcat tcaggccaaa gtctttatcc gccaagaccc 3704221 ttcacctctt ttcctaaact gctgtatcta ttgtacaaaa aaactgatca taagagcaat 3704281 caagataccc gaaaagaaat acatcctctt atttccattt actcaaaata ggatataaga 3704341 gcagacaaac taacaaatac aaattgagca tcccatatat cggatacaag aacgcgatca 3704401 aatcagaaaa tccgaaagaa gtaaaaggta ccattaacac taacaaaatc aacacaatca 3704461 tccatctcgg catatgaata aacgccatca gccggctgga caaacccagc aaaccagcta 3704521 ccgtcgtcgt gtaaatcgcc aggcacagca ccgccgtcat acataaaaaa aggaaataag 3704581 gcgcaccctc cagaacggca aacagcggta tttcaaactg agaaagggag cccgccagct 3704641 ccaccaacgt ttcattataa acaaatgaga tcacgccaaa aataagaccg cttgccacac 3704701 ttgcgatttt tgcttctccg agccctttca tctctttccc aacagaggat aaaatcgcaa 3704761 caactgaaag gatgtttaaa gaggtaaacg taatgctcgc aggccagtta tactgctggg 3704821 acaaatcaat cgtccacgta tggtgatgtg tgctctgaaa ggagatcagc gcatataaaa 3704881 gccccgctac taacacagga atcaaaatac tatttataga taatattcct ttcacatccc 3704941 acaaaaacaa gcacactgtc acgatgcaaa tcagcgtgat tccccaccag aaaggaagct 3705001 tgtacatttg cagggtcaca ccgcctccgg caatcatcac catagtcgtc gaaaacaaat 3705061 aaaaaatgat gaggacatca taaattttcg ccagccatgg ccccattaaa tgctccagaa 3705121 ccggcagaaa atgagtggat tgaaccttaa aactgatttt catcacaata taagacgaga 3705181 aaatgaacat aattgtaaac agcacaatag caagtccgct ttccgcccca aaaaactgcc 3705241 atatctcctg accgctcgca tatccggccc cgatcaggct ccctaatatg agcagcatcc 3705301 acttcattcc ggctctccac aacactatca cctcatagac aaagttcagc ttgttcccgt 3705361 tattgttact atataaataa aggaaagcaa acatgccata ttttcataga catttgaaca 3705421 caagctgaaa ttatcatacg aaatacacat aaaaaagact gctaatacgg cagtctaaaa 3705481 agagatattt atttgtttgt ccgcggaatg aagaagtgaa cttcactctt cacttttttc 3705541 taaccattcc tacctattca agtgtttcat aagcagacca ttgcttgatc atgatcgagg 3705601 caatggggga caatacttgt aatcgcccac taaccattca tatcatgccc tctacttttt 3705661 taaaatctct ggtgccatac acaaagcata aaaaatcata ctgctggata tactgtaaac 3705721 aaccttacat aactacacac accatagcaa ttctgttacc tactataaca aggaagtgaa 3705781 acccatgaat cgaaaaggcg ggcttttttc ttctcaggaa cgagtaaagc aatatgtttc 3705841 acatacagat gctgcagcgg caaaacaaat ccaaaccatc ctttcttcat ccttacgtaa 3705901 agctgctggc aaaccaattg tcgtggtttg tatcggaaca gaccgttcaa ccggtgactc 3705961 attaggcccg ctcgtaggaa tgaaactcaa acagatgcag ctcaccagat tccatgtcta 3706021 cggaacctta tctgaccccg tccatgctgt gaacatgaag gataaaatca atgacattca 3706081 taaattacat aaaaacccat ttgttatagc agtcgatgca tgcttaggcc gcgttaagag 3706141 tgtgggttca tttcaaatcg gggacgggcc attaaagccc ggagccggtg tacaaaaaga 3706201 ccttcctgaa gtgggagatc ttcatattaa cggaatcgtg aatgtgagcg gttttatgga 3706261 atattttgta ttgcaaaata ctagactcaa cttggtcatg aatatggcaa atgttctagc 3706321 ggaaggtttg agtttaacag atcggacaga gtggaggcaa gaacgcctta acccgttgca 3706381 aaggctcact gggcgcatat aaaataaaaa ccatcttcgt ttgaaagatg gttttttcat 3706441 ttatgattct cgttcagaca aaagctctaa aatccggtca aggtcttcat tagagaaaaa 3706501 ttcaatttcg attttgcctt ttttcttctg tcttttaata ttaactgttg ttccaaaata 3706561 attttggaga taggattccc gttcttttag aaccgcatct ttcacaggtt cttttttctt 3706621 tgtttcacgt ggaacattct gattcaactg ctgaatcagc tgctcaagtt ggcgaacatt 3706681 gagctgctcc gcaatcactt tttgtaccag cggttcaagc ttatttttgt tttttaagcc 3706741 aagaagcgtg cgtccatgtc ccatagaaag cgtgccttcg gcaataagct gttgaatatt 3706801 ttctggcagt gtcagcagtc ttaaatgatt cgcaatatgc ggtctgcttt tcccaagacg 3706861 tttggcaagc tgctcttgtg tgagatctaa gtgtttcaaa agggagtcat atgcctgagc 3706921 ctcttcaagc ggagataaat cttcacgctg aaggttttct aataaagcaa tttccctcat 3706981 taacgcctct gataattcac ggacaatggc cggaactgta tctaaacctg ccagctttgc 3707041 cgctcgaaaa cgccgttcac ccgcaacaat atcatagcct tttaaagatt ttctgacgat 3707101 aagcggctga agaatgccat gctgcagcac agattctttt agttcagcta atgcctcgtc 3707161 atcaaagtgt tttcttggct gataaggatt agggcgtaaa tcggcaattt taatttcttc 3707221 aactgtctct tcagacaaat ctacctgatt aaataacgca ttaatccctt ttccaaggcc 3707281 tttagccatt cgcagccact tcctttgcta aatctaaata tacttccgca cctcttgacc 3707341 gcggatcgta taaaatgatg ggttttccgt gactcggtgc ctcactcaga cggacattac 3707401 gcggaataac tgtcttatat actttatccc taaaatactt tttaacctct tcaatcactt 3707461 gaatgccaag gtttgtccgg gcatcaagca ttgtcagcaa tacaccttca atcattaaat 3707521 cagtattcaa atgcttttgc acaagacgta ctgtatttaa taactggctg agaccctcca 3707581 aggcataata ttcgcactgt acaggaatca caacggaatc cgaggcagta agggcattaa 3707641 tcgtcagcaa gcccaatgac ggcggacaat caatgataat ataatcataa ttttgcttta 3707701 ctgcttcaag cgctctcttc aatctcactt ctcttgatat tgtaggaacc agctcgatct 3707761 cagcccctgc aagctgaatc gtcgcaggaa tcacatccaa gttctctact gtcgttgctt 3707821 taataatatc tattacatct gcatcatcta ctaaaatatc gtacacacac tgctctacat 3707881 cggctttttc aatccctaat ccgcttgtcg catttccctg cggatcaata tctaccagca 3707941 gaaccctttt ccctatgtaa gccaaacatg ccccaaggtt gacagacgtc gttgttttgc 3708001 cgaccccgcc tttttggttc gtaattgcta tgatttttcc cacgatgtca cctactttca 3708061 catgaacatg tactatcttg cttctattct atcaaaaaaa gattaaagcg tttcattttt 3708121 ttcatcattt tgttccgaat cagaagggaa ataattgaaa attcaagcac gctttatgct 3708181 ttctcttata aattctgcaa tttctatgtt tttttgactt aaaaaaggaa tttcttaaag 3708241 aaaaaaagaa gaagtcacag tacagaacgt ggaaacagga tggtgagaaa atggtttatc 3708301 aaacgaagag agatgtaccc gttacgctga tgattgtgtt tctcatatta ctgatacaag 3708361 cagatgccat tgttcctttt gtgctgggaa atatgagagt ttccggctgg atcattttta 3708421 ttctgctgac tcttttaaat ggactcatca tttggagctt tattgaccta aaatatgtat 3708481 tgaaggaaca ccatctgatc attaaagccg gattgatcaa acatcaaatt ccttatgaaa 3708541 acatcgataa agtcgttcaa aaaaagaaac tatggtccgg ttttcgtctg atcggctctc 3708601 gccatgccat cacaatatat tatcaggggg gatggggaca tgcagtaatt tcaccgcaaa 3708661 aatctgaaga atttatccac aagctcaaag aaaagaattc taatataata atattcacta 3708721 aaagtaagtg attacctttt gttaaaaata taaaaagctc tcctgctttt caggagagct 3708781 tctattttgg tatgcgaatc gttaattgaa tatattcttc aaattcttct tcttccgtat 3708841 tcaattttac accgctgtct tccaccattg atagtgactg gcgaatcgtg ttcatcgcaa 3708901 ttcttgtatc tctgctgaat gctttgcgtc tcggctttgg ctttctctgg ccttgctcca 3708961 gcattttcac cacgcggtct tctgtctgct ttacatttaa acttttctca ataatctctg 3709021 tgagcagtgt gacttggagc tcaggctgtt tcagcggaat cagtgctctg gcatggcgct 3709081 cggtgatttt cttctccata atcgcctctt ggaccggctg aggcagcttt aataaccgaa 3709141 gcttattcgc gattgtagac tgcccttttc ctaagcgctg tgcgagtgcc tcctgtgtta 3709201 aatcatgcag ctcaagcagc ctagcataag catgcgcttc ctcaatagaa gacagttctt 3709261 cccgctgcaa gttttcgatt aacgccacag aagcggtttc cgtgtcggaa aaatccttaa 3709321 taattgccgg aatcttttcc cactcaagcg attgcaccgc tctccagcgt ctttcacctg 3709381 caatgagttc gtattggcct tcttcttctg tatgcctaac aacaatcggc tgaataatgc 3709441 cgtgtgtatg aatggtcatt gctaactctt tgattttttc atctgagaaa atggtgcgtg 3709501 gctgaaaacg gttgggaacg atagcattta ccggtatttc cagaatctct tctttgtttg 3709561 tatcatgttc agcaatctcc ggctcctgtt ccttctcacc aagcccgaag aaacgagaga 3709621 atgaatgctt catgtaccta caccaccttt aaaaactgcc atttttataa ttctattttc 3709681 tcatggtttt tcctgctgta catccatcaa ttttgatgaa aatatgatgg tattgtcata 3709741 tcaggctgtc taaattaccc ttcaattggc gatttattag gagttcccgg ttttcttgga 3709801 tacttcttag gtgtattttt tattttgcgt atcaccataa tattacgatc gctttcttca 3709861 ataggcagct taaaagaatg gatattctca agttctcctc caagcgtcgt gattgctttt 3709921 ttgcctgcat tcagttcttc ttcagctgat gcggctttta aagcaacaaa taaaccgttt 3709981 ttcttcacca gaggcaagca aagctcactc aaaacagata atctcgcaac tgcgcgcgcc 3710041 gtcacaatat catagctttc acgcacgtct ttccgttgcc cgaacgtttc agctctgtca 3710101 tggcagaatg ttgtattctc caattgcaaa gcttcagaca acttttctaa aaacgtaatc 3710161 cgtttgttta gtgaatccac gattgtgaca tggaggtgcg gaaagcatat ttttatcggc 3710221 agacttggaa aacccgctcc cgctccaaca tcacaaatcg tgttcacctg attgaagtcg 3710281 acataaaaag cagctgtaat ggaatcataa aaatgcttta aatacacttc ttttttctct 3710341 gttattgaag tcagattgat tttttcgttc cattcaacca gcatgtcgta atacagctca 3710401 aattgctcca gctgacgggg agaaagggag atcccttttt ccgccaaacc agaagtgaat 3710461 tcttcaatat tcatgccgtc atcctttcta ctcggctatc ttcgcaatgc gtccctgctc 3710521 taaatacacc aatagaattg aaatgtccgc cgggtttaca ccggaaatgc gggaagcctg 3710581 ggcaacagac aaaggccgta catttttcag tttttgacgc gcctcggtcg caatcccctt 3710641 aattgcgtca taatcaattc ggtctggaat ttttttattt tccatcttct tcagtttttc 3710701 cacttgctga agagattttt caatatatcc ttcatatttc acttggattt ctacttgttc 3710761 tgccacgtct tgaggaaccg gcacttctgg cggcgccagt tttgtgactg tttcatagtt 3710821 catttcagga cgtttcatca agtctgtgcc gcgaactcca tctttcaatt cgcttccgcc 3710881 aagagaacgg atatattctt gattttccgg agacggcttg ataattacag aatgaagacg 3710941 ttttttctcc gcctcgatcg ccgctttttt cttctcaaaa gccgcatagc gctcatcaga 3711001 aatcaatcca atgcgatgtc cgatttctgt cagacgcaaa tcagcattgt catggcgaag 3711061 cagcaatctg tattccgcac gtgatgtcaa aagacgatat ggctcattgg taccttttgt 3711121 cacaaggtca tcaatcagaa caccaatata ggcgtcagaa cggcttagaa ttacttcttc 3711181 ttttccaagc gcttttcgtc ctgcattgat tcccgccata atcccttgtc ccgcagcttc 3711241 ttcataaccg gatgttccgt taatttggcc tgcagtataa aggtttgtga tttttttggt 3711301 ttcaagtgtc ggccatagct gtgtcggtac gattgcatca tactcgatcg catagccggc 3711361 tctcatcatt tgcacgtttt caagtccagg aatcgttgca agcattcttt gctgtacgtc 3711421 ttctggaaga cttgtagata aaccttggac atagacttcc tgtgtatttc tgccttccgg 3711481 ctcaaggaag atttggtgac gcggtttatc attaaaacgg acaactttgt cttcaatgga 3711541 tgggcagtat cttgggcccg tacctttgat cataccggaa tacatcggtg aacggtgcag 3711601 gttgctgtca ataatctcat gtgtctcagg gcttgtatat gtcagccagc aagggagctg 3711661 atctgtgata tattccactg tttcatatga gaaagcgcga ggcacatcgt caccaggctg 3711721 aatttccgtt ttgctgtaat caatcgtgtc gcttttaacg cgaggcggcg tacctgtttt 3711781 aaaacgaaca aggtcaaaac cgagttcctc caaatgctca gaaagcttaa tagaaggctg 3711841 ctggttattc gggccgcttg agtaagacag atcgccaaga atgatacgtc ctcttaaata 3711901 tgtccctgtc gtcatgacaa ctgctttcgc acgataatgt gcgcctgttt gtgtaataac 3711961 gcctcggcat tcgccgtctt caacgatcag ccgctccaca attccttgca gcaatgttaa 3712021 gtttggttct ttttcaagcg tatttttcat ttcgtgctga tattggaatt tgtctgcttg 3712081 cgcacgcaat gcacgaaccg caggaccttt tcctgtattc agcattctca tttgaatatg 3712141 tgttttatcg atgtttcttc ccatttctcc gccgagcgcg tcaatttcgc ggacgacaat 3712201 cccttttgcg gggccgccga cagacggatt acatggcata aatgcaacca tatctaggtt 3712261 gatggtcaag acaagcgttt tggcgccttg gcgtgcagat gcgagggcag cctcaacacc 3712321 ggcatgcccg gcgccaatca caatcacatc gtattggcct gcttcatacc ccatgattct 3712381 agttcctcct ttaattattt tcctaaacag aattgagaaa agagctgatc aattaagctt 3712441 tcgtggacag aatctccaat gatttcccct aaaagctccc agcatcttgt aaggtcaatt 3712501 tgcaccatgt cgatcgggac atcctgttcg atgccgctaa gcgcatcttc aatggcgcgt 3712561 tttgcttgct gtaaaatagt gatgtgacgt gtgttgctga cataagtcag atcaccgctt 3712621 tcaatggcac ccgtgtagaa cagtgattga atcgcttctt ccagatcatt gatgccttcc 3712681 tcttttaaaa gagatgtcgt aacaactgga cgtccattgg caagctcacg gacacgttca 3712741 gtgtcaatct tcggctcaag gtcagtctta ttcaaaatca cgataacatc catgccctca 3712801 acggcttcaa aaagcttcac gtcttcttca gaaagctctt cactataatt aagcacaagt 3712861 aaaatcaggt ccgcttcctt taggacctgg cgagaacgtt caacaccgat tcgctcaaca 3712921 atatcctctg tttcacgaat acctgctgta tcaaccagac gaagcggaac gccccttaca 3712981 ttcacgtatt cctcaatcac atcccgtgtc gttccgggaa tatcggttac aatggctttt 3713041 gcctcatgaa cgaggctgtt cagaagagat gattttccta cgtttggccg gccgataatg 3713101 acggtagaaa gaccttcacg caagattttt ccttgctcag aagtcctcag cagcgtctca 3713161 atttcctttt tcacggcggt tgccttttcg actaaaatct gatgcgtcat ttcctctaca 3713221 tcatcatact ccggataatc aatattcacc tcaacatggg ccagtgtttc taaaatctca 3713281 ctgcgcaaac ggcgcaccaa agcagaaaga cgcccttcca tttgattcat agcaacgttc 3713341 attgcccggt ccgttttcgc tctgattaag tccataaccg cttccgcctg tgaaagatcg 3713401 attcggccgt ttaaaaacgc acgtttcgta aattcaccag gctctgccag tctcgctccc 3713461 tctctcaatg caagctgaag cacttggttc acagtcacaa ttcccccgtg acagttaatc 3713521 tcgatgacat cttctcgtgt aaaagttctc ggcgctttta acactgatac cattacttcc 3713581 tcaacgacac gatccgaagg tctgtctacg atatgaccat aatgaatcgt atgtgattcg 3713641 accgagctga gtgttttccc cttcggtccc ttataaattt tatctgcgat ttgaatggct 3713701 tctggtccgc tcaaccgtac aatcgcaatc gcgccttctc ccatcggtgt ggaaattgcc 3713761 gcaattgtat ccatgttgtt cacctctctt tacttatact tcatctatat aaaaaaattt 3713821 ttattatgcc aaaactaaaa gataacatag tttggttcga agtggaagat ttgttatcca 3713881 cagaaataga aattcgtccc ttattacttt aacttatcca catgtgaata acaattaatt 3713941 ttatttcctg aacttccttt ttatcaacag gatacaccta aaaagaaaaa acttaaacgg 3714001 caaaaccttg atattactag gaaaagtaga tttttcggat acaaaaaaac cgaaatccaa 3714061 tttttatcgg acttcggttt tatgctatct tttatgggaa ataacgagat gacgattttc 3714121 gccttcaccc attgaatatg ttttgatctg gtggtttgca tatccagaaa gagtatcgtg 3714181 aataattttt ctttcgctgg acggcatggg ctcaagctgg atggattttt tcgttttcaa 3714241 aacctggtca gcaagcttga tggccagctg gctcagtgtt tcttttcttt tcaaacgata 3714301 gttttctgca tccaccgtca catttttata ttggcctgga taacggttaa gggcaagctg 3714361 tgtcaaagtt tcaagggcgt ttaaagtttg tcctcttttc ccaatcaaca atgctgcctt 3714421 ttcacctgtt atatgatatc tcactgtctt tttgctttct tgaacagtca catcagactt 3714481 cccggcaatg gcttcggcaa tcgtttgaag atataacttc gcttgctgaa tcggatcaat 3714541 cttttcaacc agctttacga tcgcaggctt tttaccgaaa ataccgagaa accctttgtt 3714601 tccctcttca ataacagtaa tttctacctt atccttcgtt aatcccaact cttgcaatcc 3714661 ggactgtact gcttcatcga catttcgccc tgcagcagtc acattcctca ctttttcttt 3714721 cctccggctt tttgcggctc aggatttttt ttaatatcag gtcctttaat gaggaaagtt 3714781 tgcgcaatca taaacaagtt accaactacc caataaagag aaagagccgc cgggaagttg 3714841 atcgcaaata cgataatcat aattggcata atccaaagca tcatcgccat ttgcggattt 3714901 tgctgcgcat tgccagccat catcagtttt tgctgaacaa atgtagcgac accggcaacg 3714961 ataggaagaa tatagtaagg atctttttct cctaagtcaa accataagaa gctatgctct 3715021 gaaatcgcct gggttctcat gatcgcatga tagaatccaa ttaaaatcgg catctggatc 3715081 aaaatcggga aacatcccgc caatggattg acaccatgct tttggaataa agccattgtt 3715141 tcctgttgaa gcttttgctg cgttttttga tcctttgagc tgtatttttc tttaagcttt 3715201 tgcatttccg gctgtaaagc ctgcatcgct ttcgaacttc tcagctgctt aatcatcagc 3715261 ggtaaaatta ataaacgaat taaaatggta actagaataa ttgaaagccc gtagttatct 3715321 cccgtcaatt tcgctacata cgtaatgagc tcagacaatg gatatactac gtacttgtcc 3715381 cagaaatgcg gactatctgc agtgatcggc tctttcacac tcgagcatcc agccaaaagc 3715441 atgaatacgc caaccatact taatagcaac cctattctcc ttttcaacaa catttcctcc 3715501 tataattaat ctttacactc ttttattgca aagcatactt gtatgtattt tagcatcttt 3715561 cagttttaaa tggtgtcttt ttctgatcaa ccagaaagga agcgctttta aaagttgtaa 3715621 gaaagcagtg gtgatgccta ctttgacgaa gatttcttat ataatgaaga ctttctgaat 3715681 agatgctgca gacttttttt cgtttcctca tatgtcagct ggctcgccgg ttttctggca 3715741 ataatgatgt aatccttttc cttcagtctc tctttctctt caagaaaggc ctgccgaatc 3715801 aaacgtttga tccgatttcg catcacagca ttgccaattt ttttgctgac ggaaagcccg 3715861 acacgcagtt catcattttc aggctgatca agcgtatata agacaaactg gcggtttgca 3715921 actgatgtcc catgtttaaa cactttttga aaatcttcat ttttctttaa acgatttcgc 3715981 ttcttcaaat gactcactcc gatactggct ggcagaaact tttaaaattt attatgaaca 3716041 tgagatgcat ctgaaccagg aagcatgccc cggttcatta cgcatcacat ctatcttttc 3716101 ccataacgtg aaaaaagacc actgacatta ttcagtggcc taagctgata atacttttct 3716161 gcctttgcgg cgacggcgtg ctaaaactag acgaccgttt tttgaactca tacggcttct 3716221 gaagccatga actttgctgc gtttacggtt attcggttgg aatgttcttt tcatttatga 3716281 cacctccctc gaggaatagc tgttaaagac agtcttactt attatatttg cgttacctat 3716341 tcattgtcaa cttcactagt gcttttattt cttgcaacca taataggata ccataccttt 3716401 tcaactttcg aaaccttatt ttttagattc cttaatttta cggaaaaaag acaaattcaa 3716461 acaatttgcc cctaaaatca cgcatgtgga tatctttttc ggcttttttt agtatccaca 3716521 gaggttatcg acaacatttt cacattacca acccctgtgg acaaggtttt ttcaacaggt 3716581 tgtccgcttt gtggataaga ttgtgacaac cattgcaagc tctcgtttat tttggtatta 3716641 tatttgtgtt ttaactcttg attactaatc ctacctttcc tctttatcca caaagtgtgg 3716701 ataagttgtg gattgatttc acacagcttg tgtagaaggt tgtccacaag ttgtgaaatt 3716761 tgtcgaaaag ctatttatct actatattat atgttttcaa catttaatgt gtacgaatgg 3716821 taagcgccat ttgctctttt tttgtgttct ataacagaga aagacgccat tttctaagaa 3716881 aaggagggac gtgccggaag //